Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-08-19
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## RNA meth
## A1BG -3.3590111 0.9487855
## AAAS -0.7287326 0.4334437
## AACS -0.6787675 0.8690806
## AAGAB 1.3669141 0.5727567
## AAK1 0.2026914 0.7201373
## AAMDC -1.6832172 0.8935852Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 9321 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 5538 |
| num_profile_genes_not_in_sets | 3783 |
| profile_pearson_correl | -0.04528 |
| profile_spearman_correl | -0.05083 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2400 |
| num_genesets_excluded | 1276 |
| num_genesets_included | 1124 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 72 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.RNA | s.meth | p.RNA | p.meth |
|---|---|---|---|---|---|---|---|---|
| Eukaryotic Translation Elongation | 70 | 7.59e-37 | 8.53e-34 | 0.8840 | -0.8790 | -0.08920 | 3.16e-37 | 0.1980 |
| Peptide chain elongation | 67 | 5.10e-35 | 2.86e-32 | 0.8800 | -0.8740 | -0.10200 | 2.84e-35 | 0.1510 |
| Formation of a pool of free 40S subunits | 76 | 2.34e-33 | 8.75e-31 | 0.8070 | -0.8030 | -0.08160 | 8.55e-34 | 0.2200 |
| Selenocysteine synthesis | 68 | 7.34e-33 | 2.06e-30 | 0.8470 | -0.8450 | -0.06500 | 1.60e-33 | 0.3550 |
| Eukaryotic Translation Termination | 70 | 6.85e-32 | 1.54e-29 | 0.8220 | -0.8180 | -0.08080 | 2.23e-32 | 0.2440 |
| Viral mRNA Translation | 67 | 1.17e-31 | 2.20e-29 | 0.8370 | -0.8330 | -0.08070 | 3.65e-32 | 0.2540 |
| Selenoamino acid metabolism | 76 | 2.49e-30 | 4.00e-28 | 0.7690 | -0.7640 | -0.08340 | 9.51e-31 | 0.2100 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 85 | 3.00e-29 | 4.22e-27 | 0.7150 | -0.7130 | -0.05340 | 5.85e-30 | 0.3960 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 86 | 6.00e-28 | 7.50e-26 | 0.6950 | -0.6940 | -0.04310 | 9.45e-29 | 0.4900 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 72 | 1.06e-27 | 1.19e-25 | 0.7540 | -0.7510 | -0.07310 | 2.90e-28 | 0.2850 |
| Cap-dependent Translation Initiation | 93 | 2.18e-26 | 2.05e-24 | 0.6490 | -0.6480 | -0.04020 | 3.37e-27 | 0.5040 |
| Eukaryotic Translation Initiation | 93 | 2.18e-26 | 2.05e-24 | 0.6490 | -0.6480 | -0.04020 | 3.37e-27 | 0.5040 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 76 | 3.13e-26 | 2.71e-24 | 0.7140 | -0.7120 | -0.06280 | 7.07e-27 | 0.3450 |
| SRP-dependent cotranslational protein targeting to membrane | 85 | 6.98e-22 | 5.61e-20 | 0.6140 | -0.6070 | -0.09060 | 3.75e-22 | 0.1500 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 86 | 1.12e-21 | 7.87e-20 | 0.6090 | -0.6070 | -0.05340 | 2.27e-22 | 0.3930 |
| Nonsense-Mediated Decay (NMD) | 86 | 1.12e-21 | 7.87e-20 | 0.6090 | -0.6070 | -0.05340 | 2.27e-22 | 0.3930 |
| Translation | 234 | 2.81e-21 | 1.86e-19 | 0.3660 | -0.3560 | -0.08700 | 1.09e-20 | 0.0228 |
| Influenza Viral RNA Transcription and Replication | 110 | 1.10e-20 | 6.85e-19 | 0.5270 | -0.5270 | -0.03070 | 1.56e-21 | 0.5800 |
| Regulation of expression of SLITs and ROBOs | 122 | 3.08e-19 | 1.82e-17 | 0.4820 | -0.4790 | -0.04960 | 7.22e-20 | 0.3460 |
| rRNA processing | 159 | 5.58e-18 | 3.14e-16 | 0.4070 | -0.4030 | -0.06150 | 2.47e-18 | 0.1830 |
| rRNA processing in the nucleus and cytosol | 154 | 6.43e-18 | 3.44e-16 | 0.4130 | -0.4090 | -0.05980 | 2.57e-18 | 0.2030 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 147 | 1.59e-16 | 8.12e-15 | 0.4050 | -0.3990 | -0.06640 | 7.77e-17 | 0.1670 |
| Influenza Infection | 128 | 4.20e-15 | 2.05e-13 | 0.4150 | -0.4140 | -0.02890 | 6.58e-16 | 0.5740 |
| Signaling by ROBO receptors | 153 | 2.25e-14 | 1.05e-12 | 0.3710 | -0.3710 | -0.01650 | 2.97e-15 | 0.7270 |
| Formation of the ternary complex, and subsequently, the 43S complex | 40 | 1.96e-11 | 8.81e-10 | 0.6350 | -0.6260 | -0.10900 | 7.36e-12 | 0.2330 |
| Metabolism of amino acids and derivatives | 219 | 5.69e-11 | 2.46e-09 | 0.2680 | -0.2650 | -0.04160 | 1.76e-11 | 0.2920 |
| Axon guidance | 295 | 1.02e-10 | 4.25e-09 | 0.2300 | -0.2290 | -0.02270 | 1.98e-11 | 0.5060 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 48 | 2.23e-10 | 8.95e-09 | 0.5520 | -0.5470 | -0.07510 | 5.69e-11 | 0.3690 |
| Translation initiation complex formation | 47 | 2.64e-10 | 9.93e-09 | 0.5560 | -0.5500 | -0.07690 | 6.87e-11 | 0.3630 |
| Nervous system development | 307 | 2.65e-10 | 9.93e-09 | 0.2210 | -0.2200 | -0.02290 | 5.31e-11 | 0.4930 |
| Cellular responses to stress | 392 | 3.96e-10 | 1.40e-08 | 0.1950 | -0.1950 | -0.00921 | 5.80e-11 | 0.7570 |
| Ribosomal scanning and start codon recognition | 47 | 3.98e-10 | 1.40e-08 | 0.5510 | -0.5480 | -0.06130 | 8.38e-11 | 0.4680 |
| Cellular responses to external stimuli | 397 | 1.04e-09 | 3.53e-08 | 0.1900 | -0.1890 | -0.01040 | 1.59e-10 | 0.7250 |
| Interferon Signaling | 142 | 7.49e-09 | 2.48e-07 | 0.3000 | 0.2980 | -0.03440 | 1.03e-09 | 0.4810 |
| Infectious disease | 486 | 4.63e-08 | 1.49e-06 | 0.1560 | -0.1560 | -0.00146 | 6.58e-09 | 0.9570 |
| Metabolism of RNA | 535 | 4.81e-08 | 1.50e-06 | 0.1470 | -0.1410 | -0.04040 | 3.79e-08 | 0.1160 |
| Developmental Biology | 450 | 1.10e-06 | 3.33e-05 | 0.1450 | -0.1440 | -0.01960 | 2.61e-07 | 0.4820 |
| Metabolism | 1215 | 1.29e-06 | 3.81e-05 | 0.0939 | -0.0877 | 0.03360 | 7.76e-07 | 0.0585 |
| Respiratory electron transport | 79 | 2.13e-06 | 6.15e-05 | 0.3300 | -0.3260 | -0.05060 | 5.58e-07 | 0.4380 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 80 | 2.27e-06 | 6.37e-05 | 0.3280 | -0.3250 | -0.04280 | 5.29e-07 | 0.5090 |
| Interferon alpha/beta signaling | 49 | 2.39e-06 | 6.43e-05 | 0.4250 | 0.4130 | -0.09900 | 5.75e-07 | 0.2310 |
| Mitochondrial translation elongation | 83 | 2.40e-06 | 6.43e-05 | 0.3180 | -0.2990 | -0.10800 | 2.56e-06 | 0.0902 |
| Cell Cycle Checkpoints | 221 | 3.14e-05 | 8.21e-04 | 0.1790 | 0.1790 | -0.01110 | 5.28e-06 | 0.7770 |
| Mitochondrial translation termination | 82 | 3.44e-05 | 8.78e-04 | 0.2850 | -0.2660 | -0.10200 | 3.23e-05 | 0.1100 |
| Mitotic Prometaphase | 155 | 4.12e-05 | 1.03e-03 | 0.2080 | 0.2050 | 0.03460 | 1.14e-05 | 0.4600 |
| Mitochondrial translation initiation | 83 | 4.56e-05 | 1.11e-03 | 0.2800 | -0.2610 | -0.09880 | 3.98e-05 | 0.1210 |
| Mitochondrial translation | 88 | 5.78e-05 | 1.38e-03 | 0.2680 | -0.2470 | -0.10400 | 6.57e-05 | 0.0916 |
| Antiviral mechanism by IFN-stimulated genes | 77 | 6.32e-05 | 1.48e-03 | 0.2940 | 0.2810 | -0.08670 | 2.06e-05 | 0.1890 |
| Complex I biogenesis | 41 | 7.41e-05 | 1.67e-03 | 0.3890 | -0.3790 | -0.08740 | 2.69e-05 | 0.3340 |
| Cell Cycle | 515 | 7.41e-05 | 1.67e-03 | 0.1150 | 0.1130 | -0.01870 | 1.47e-05 | 0.4760 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.RNA | s.meth | p.RNA | p.meth |
|---|---|---|---|---|---|---|---|---|
| Eukaryotic Translation Elongation | 70 | 7.59e-37 | 8.53e-34 | 0.88400 | -8.79e-01 | -0.089200 | 3.16e-37 | 0.19800 |
| Peptide chain elongation | 67 | 5.10e-35 | 2.86e-32 | 0.88000 | -8.74e-01 | -0.102000 | 2.84e-35 | 0.15100 |
| Formation of a pool of free 40S subunits | 76 | 2.34e-33 | 8.75e-31 | 0.80700 | -8.03e-01 | -0.081600 | 8.55e-34 | 0.22000 |
| Selenocysteine synthesis | 68 | 7.34e-33 | 2.06e-30 | 0.84700 | -8.45e-01 | -0.065000 | 1.60e-33 | 0.35500 |
| Eukaryotic Translation Termination | 70 | 6.85e-32 | 1.54e-29 | 0.82200 | -8.18e-01 | -0.080800 | 2.23e-32 | 0.24400 |
| Viral mRNA Translation | 67 | 1.17e-31 | 2.20e-29 | 0.83700 | -8.33e-01 | -0.080700 | 3.65e-32 | 0.25400 |
| Selenoamino acid metabolism | 76 | 2.49e-30 | 4.00e-28 | 0.76900 | -7.64e-01 | -0.083400 | 9.51e-31 | 0.21000 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 85 | 3.00e-29 | 4.22e-27 | 0.71500 | -7.13e-01 | -0.053400 | 5.85e-30 | 0.39600 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 86 | 6.00e-28 | 7.50e-26 | 0.69500 | -6.94e-01 | -0.043100 | 9.45e-29 | 0.49000 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 72 | 1.06e-27 | 1.19e-25 | 0.75400 | -7.51e-01 | -0.073100 | 2.90e-28 | 0.28500 |
| Cap-dependent Translation Initiation | 93 | 2.18e-26 | 2.05e-24 | 0.64900 | -6.48e-01 | -0.040200 | 3.37e-27 | 0.50400 |
| Eukaryotic Translation Initiation | 93 | 2.18e-26 | 2.05e-24 | 0.64900 | -6.48e-01 | -0.040200 | 3.37e-27 | 0.50400 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 76 | 3.13e-26 | 2.71e-24 | 0.71400 | -7.12e-01 | -0.062800 | 7.07e-27 | 0.34500 |
| SRP-dependent cotranslational protein targeting to membrane | 85 | 6.98e-22 | 5.61e-20 | 0.61400 | -6.07e-01 | -0.090600 | 3.75e-22 | 0.15000 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 86 | 1.12e-21 | 7.87e-20 | 0.60900 | -6.07e-01 | -0.053400 | 2.27e-22 | 0.39300 |
| Nonsense-Mediated Decay (NMD) | 86 | 1.12e-21 | 7.87e-20 | 0.60900 | -6.07e-01 | -0.053400 | 2.27e-22 | 0.39300 |
| Translation | 234 | 2.81e-21 | 1.86e-19 | 0.36600 | -3.56e-01 | -0.087000 | 1.09e-20 | 0.02280 |
| Influenza Viral RNA Transcription and Replication | 110 | 1.10e-20 | 6.85e-19 | 0.52700 | -5.27e-01 | -0.030700 | 1.56e-21 | 0.58000 |
| Regulation of expression of SLITs and ROBOs | 122 | 3.08e-19 | 1.82e-17 | 0.48200 | -4.79e-01 | -0.049600 | 7.22e-20 | 0.34600 |
| rRNA processing | 159 | 5.58e-18 | 3.14e-16 | 0.40700 | -4.03e-01 | -0.061500 | 2.47e-18 | 0.18300 |
| rRNA processing in the nucleus and cytosol | 154 | 6.43e-18 | 3.44e-16 | 0.41300 | -4.09e-01 | -0.059800 | 2.57e-18 | 0.20300 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 147 | 1.59e-16 | 8.12e-15 | 0.40500 | -3.99e-01 | -0.066400 | 7.77e-17 | 0.16700 |
| Influenza Infection | 128 | 4.20e-15 | 2.05e-13 | 0.41500 | -4.14e-01 | -0.028900 | 6.58e-16 | 0.57400 |
| Signaling by ROBO receptors | 153 | 2.25e-14 | 1.05e-12 | 0.37100 | -3.71e-01 | -0.016500 | 2.97e-15 | 0.72700 |
| Formation of the ternary complex, and subsequently, the 43S complex | 40 | 1.96e-11 | 8.81e-10 | 0.63500 | -6.26e-01 | -0.109000 | 7.36e-12 | 0.23300 |
| Metabolism of amino acids and derivatives | 219 | 5.69e-11 | 2.46e-09 | 0.26800 | -2.65e-01 | -0.041600 | 1.76e-11 | 0.29200 |
| Axon guidance | 295 | 1.02e-10 | 4.25e-09 | 0.23000 | -2.29e-01 | -0.022700 | 1.98e-11 | 0.50600 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 48 | 2.23e-10 | 8.95e-09 | 0.55200 | -5.47e-01 | -0.075100 | 5.69e-11 | 0.36900 |
| Translation initiation complex formation | 47 | 2.64e-10 | 9.93e-09 | 0.55600 | -5.50e-01 | -0.076900 | 6.87e-11 | 0.36300 |
| Nervous system development | 307 | 2.65e-10 | 9.93e-09 | 0.22100 | -2.20e-01 | -0.022900 | 5.31e-11 | 0.49300 |
| Cellular responses to stress | 392 | 3.96e-10 | 1.40e-08 | 0.19500 | -1.95e-01 | -0.009210 | 5.80e-11 | 0.75700 |
| Ribosomal scanning and start codon recognition | 47 | 3.98e-10 | 1.40e-08 | 0.55100 | -5.48e-01 | -0.061300 | 8.38e-11 | 0.46800 |
| Cellular responses to external stimuli | 397 | 1.04e-09 | 3.53e-08 | 0.19000 | -1.89e-01 | -0.010400 | 1.59e-10 | 0.72500 |
| Interferon Signaling | 142 | 7.49e-09 | 2.48e-07 | 0.30000 | 2.98e-01 | -0.034400 | 1.03e-09 | 0.48100 |
| Infectious disease | 486 | 4.63e-08 | 1.49e-06 | 0.15600 | -1.56e-01 | -0.001460 | 6.58e-09 | 0.95700 |
| Metabolism of RNA | 535 | 4.81e-08 | 1.50e-06 | 0.14700 | -1.41e-01 | -0.040400 | 3.79e-08 | 0.11600 |
| Developmental Biology | 450 | 1.10e-06 | 3.33e-05 | 0.14500 | -1.44e-01 | -0.019600 | 2.61e-07 | 0.48200 |
| Metabolism | 1215 | 1.29e-06 | 3.81e-05 | 0.09390 | -8.77e-02 | 0.033600 | 7.76e-07 | 0.05850 |
| Respiratory electron transport | 79 | 2.13e-06 | 6.15e-05 | 0.33000 | -3.26e-01 | -0.050600 | 5.58e-07 | 0.43800 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 80 | 2.27e-06 | 6.37e-05 | 0.32800 | -3.25e-01 | -0.042800 | 5.29e-07 | 0.50900 |
| Interferon alpha/beta signaling | 49 | 2.39e-06 | 6.43e-05 | 0.42500 | 4.13e-01 | -0.099000 | 5.75e-07 | 0.23100 |
| Mitochondrial translation elongation | 83 | 2.40e-06 | 6.43e-05 | 0.31800 | -2.99e-01 | -0.108000 | 2.56e-06 | 0.09020 |
| Cell Cycle Checkpoints | 221 | 3.14e-05 | 8.21e-04 | 0.17900 | 1.79e-01 | -0.011100 | 5.28e-06 | 0.77700 |
| Mitochondrial translation termination | 82 | 3.44e-05 | 8.78e-04 | 0.28500 | -2.66e-01 | -0.102000 | 3.23e-05 | 0.11000 |
| Mitotic Prometaphase | 155 | 4.12e-05 | 1.03e-03 | 0.20800 | 2.05e-01 | 0.034600 | 1.14e-05 | 0.46000 |
| Mitochondrial translation initiation | 83 | 4.56e-05 | 1.11e-03 | 0.28000 | -2.61e-01 | -0.098800 | 3.98e-05 | 0.12100 |
| Mitochondrial translation | 88 | 5.78e-05 | 1.38e-03 | 0.26800 | -2.47e-01 | -0.104000 | 6.57e-05 | 0.09160 |
| Antiviral mechanism by IFN-stimulated genes | 77 | 6.32e-05 | 1.48e-03 | 0.29400 | 2.81e-01 | -0.086700 | 2.06e-05 | 0.18900 |
| Complex I biogenesis | 41 | 7.41e-05 | 1.67e-03 | 0.38900 | -3.79e-01 | -0.087400 | 2.69e-05 | 0.33400 |
| Cell Cycle | 515 | 7.41e-05 | 1.67e-03 | 0.11500 | 1.13e-01 | -0.018700 | 1.47e-05 | 0.47600 |
| Homologous DNA Pairing and Strand Exchange | 38 | 7.62e-05 | 1.68e-03 | 0.40500 | 3.99e-01 | 0.069000 | 2.14e-05 | 0.46300 |
| Resolution of Sister Chromatid Cohesion | 90 | 8.46e-05 | 1.83e-03 | 0.26700 | 2.63e-01 | -0.047300 | 1.75e-05 | 0.43900 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 35 | 1.49e-04 | 3.15e-03 | 0.40800 | 4.07e-01 | 0.032600 | 3.14e-05 | 0.73900 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 81 | 4.36e-04 | 8.90e-03 | 0.25500 | 2.52e-01 | -0.038500 | 9.08e-05 | 0.55000 |
| Amplification of signal from the kinetochores | 81 | 4.36e-04 | 8.90e-03 | 0.25500 | 2.52e-01 | -0.038500 | 9.08e-05 | 0.55000 |
| G2/M DNA damage checkpoint | 52 | 5.02e-04 | 1.01e-02 | 0.31000 | 3.07e-01 | 0.046300 | 1.33e-04 | 0.56400 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 23 | 6.29e-04 | 1.24e-02 | 0.46300 | 4.63e-01 | -0.015300 | 1.24e-04 | 0.89900 |
| Cell Cycle, Mitotic | 417 | 6.39e-04 | 1.24e-02 | 0.11200 | 1.10e-01 | -0.022200 | 1.49e-04 | 0.44300 |
| HDR through Single Strand Annealing (SSA) | 34 | 8.10e-04 | 1.54e-02 | 0.36800 | 3.51e-01 | 0.111000 | 3.99e-04 | 0.26200 |
| EML4 and NUDC in mitotic spindle formation | 85 | 9.74e-04 | 1.83e-02 | 0.23700 | 2.31e-01 | -0.053000 | 2.47e-04 | 0.40000 |
| The citric acid (TCA) cycle and respiratory electron transport | 118 | 1.16e-03 | 2.14e-02 | 0.19500 | -1.92e-01 | -0.031500 | 3.26e-04 | 0.55600 |
| Interferon gamma signaling | 55 | 1.21e-03 | 2.19e-02 | 0.28300 | 2.76e-01 | 0.061400 | 4.07e-04 | 0.43100 |
| Mitotic Spindle Checkpoint | 96 | 1.30e-03 | 2.32e-02 | 0.21800 | 2.11e-01 | -0.055000 | 3.59e-04 | 0.35300 |
| Pausing and recovery of Tat-mediated HIV elongation | 25 | 1.60e-03 | 2.76e-02 | 0.41800 | -4.12e-01 | 0.073300 | 3.71e-04 | 0.52600 |
| Tat-mediated HIV elongation arrest and recovery | 25 | 1.60e-03 | 2.76e-02 | 0.41800 | -4.12e-01 | 0.073300 | 3.71e-04 | 0.52600 |
| Disease | 870 | 1.88e-03 | 3.20e-02 | 0.07290 | -7.28e-02 | 0.002300 | 3.96e-04 | 0.91100 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 26 | 2.05e-03 | 3.44e-02 | 0.40400 | 3.89e-01 | -0.108000 | 6.00e-04 | 0.34200 |
| Metabolism of carbohydrates | 177 | 2.26e-03 | 3.74e-02 | 0.15600 | -1.41e-01 | 0.065800 | 1.27e-03 | 0.13300 |
| Regulation of PTEN gene transcription | 49 | 2.39e-03 | 3.89e-02 | 0.28800 | -2.87e-01 | 0.019400 | 5.12e-04 | 0.81500 |
| Resolution of D-Loop Structures | 27 | 2.89e-03 | 4.64e-02 | 0.38500 | 3.70e-01 | -0.107000 | 8.78e-04 | 0.33800 |
| E2F mediated regulation of DNA replication | 18 | 3.03e-03 | 4.76e-02 | 0.47300 | 4.25e-01 | -0.206000 | 1.78e-03 | 0.13100 |
| ISG15 antiviral mechanism | 70 | 3.05e-03 | 4.76e-02 | 0.23900 | 2.27e-01 | -0.075900 | 1.06e-03 | 0.27300 |
| Regulation of RUNX1 Expression and Activity | 15 | 4.61e-03 | 7.10e-02 | 0.49900 | 4.38e-01 | -0.239000 | 3.30e-03 | 0.10900 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 19 | 4.71e-03 | 7.15e-02 | 0.44400 | -2.68e-01 | 0.354000 | 4.30e-02 | 0.00753 |
| Glycosaminoglycan metabolism | 61 | 4.92e-03 | 7.38e-02 | 0.24800 | -1.82e-01 | 0.168000 | 1.41e-02 | 0.02350 |
| HIV elongation arrest and recovery | 26 | 5.28e-03 | 7.70e-02 | 0.37000 | -3.65e-01 | 0.056700 | 1.28e-03 | 0.61700 |
| Pausing and recovery of HIV elongation | 26 | 5.28e-03 | 7.70e-02 | 0.37000 | -3.65e-01 | 0.056700 | 1.28e-03 | 0.61700 |
| mRNA Splicing - Major Pathway | 144 | 5.87e-03 | 8.45e-02 | 0.15600 | -1.55e-01 | 0.010500 | 1.35e-03 | 0.82900 |
| PCP/CE pathway | 71 | 6.41e-03 | 9.12e-02 | 0.22100 | -2.13e-01 | 0.059400 | 1.95e-03 | 0.38800 |
| M Phase | 292 | 7.12e-03 | 1.00e-01 | 0.10900 | 1.08e-01 | -0.015000 | 1.73e-03 | 0.66200 |
| rRNA modification in the nucleus and cytosol | 47 | 7.53e-03 | 1.05e-01 | 0.25800 | -2.17e-01 | -0.139000 | 1.02e-02 | 0.09890 |
| mRNA Splicing - Minor Pathway | 44 | 7.77e-03 | 1.07e-01 | 0.27300 | -2.71e-01 | 0.028700 | 1.86e-03 | 0.74200 |
| HSF1-dependent transactivation | 25 | 8.36e-03 | 1.13e-01 | 0.35100 | -3.19e-01 | -0.145000 | 5.79e-03 | 0.20900 |
| Diseases associated with glycosaminoglycan metabolism | 15 | 9.57e-03 | 1.28e-01 | 0.46500 | -2.30e-01 | 0.404000 | 1.24e-01 | 0.00678 |
| Pexophagy | 10 | 1.03e-02 | 1.36e-01 | 0.53900 | -4.00e-01 | -0.361000 | 2.85e-02 | 0.04840 |
| Sphingolipid de novo biosynthesis | 23 | 1.06e-02 | 1.38e-01 | 0.35400 | 2.59e-01 | 0.242000 | 3.19e-02 | 0.04470 |
| TCF dependent signaling in response to WNT | 117 | 1.21e-02 | 1.56e-01 | 0.16400 | -1.07e-01 | 0.124000 | 4.69e-02 | 0.02110 |
| Telomere Maintenance | 55 | 1.25e-02 | 1.60e-01 | 0.23400 | -2.22e-01 | 0.076700 | 4.55e-03 | 0.32600 |
| Metabolism of proteins | 1263 | 1.41e-02 | 1.78e-01 | 0.05040 | -4.90e-02 | -0.011700 | 5.02e-03 | 0.50500 |
| Signaling by Hippo | 12 | 1.42e-02 | 1.78e-01 | 0.47400 | 3.02e-01 | 0.365000 | 7.01e-02 | 0.02850 |
| RHO GTPases Activate Formins | 100 | 1.44e-02 | 1.78e-01 | 0.16900 | 1.69e-01 | -0.013600 | 3.61e-03 | 0.81500 |
| SUMOylation of intracellular receptors | 19 | 1.47e-02 | 1.79e-01 | 0.38700 | -4.56e-02 | 0.384000 | 7.31e-01 | 0.00374 |
| Intracellular signaling by second messengers | 204 | 1.50e-02 | 1.81e-01 | 0.12100 | -9.69e-02 | 0.072900 | 1.77e-02 | 0.07440 |
| mRNA Splicing | 151 | 1.56e-02 | 1.86e-01 | 0.13700 | -1.37e-01 | 0.003630 | 3.92e-03 | 0.93900 |
| TRAF6 mediated IRF7 activation | 15 | 1.64e-02 | 1.94e-01 | 0.41700 | 3.47e-01 | 0.232000 | 2.01e-02 | 0.11900 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 32 | 1.73e-02 | 2.03e-01 | 0.28400 | -2.07e-01 | -0.194000 | 4.33e-02 | 0.05710 |
| Metabolism of lipids | 427 | 1.83e-02 | 2.12e-01 | 0.07930 | 3.44e-02 | 0.071400 | 2.28e-01 | 0.01260 |
| Processing of DNA double-strand break ends | 54 | 1.88e-02 | 2.15e-01 | 0.21800 | 1.97e-01 | 0.091700 | 1.22e-02 | 0.24400 |
| Regulation of TP53 Activity through Acetylation | 26 | 1.90e-02 | 2.15e-01 | 0.32000 | -3.19e-01 | 0.027600 | 4.90e-03 | 0.80800 |
| CDC6 association with the ORC:origin complex | 10 | 1.92e-02 | 2.15e-01 | 0.52200 | 4.91e-01 | -0.176000 | 7.19e-03 | 0.33600 |
| Peptide hormone metabolism | 26 | 1.96e-02 | 2.18e-01 | 0.31300 | 2.98e-01 | 0.094600 | 8.48e-03 | 0.40400 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 15 | 1.99e-02 | 2.19e-01 | 0.41500 | -4.90e-02 | -0.412000 | 7.43e-01 | 0.00578 |
| Mitochondrial protein import | 47 | 2.00e-02 | 2.19e-01 | 0.23700 | -2.36e-01 | 0.019000 | 5.18e-03 | 0.82200 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 14 | 2.03e-02 | 2.20e-01 | 0.44000 | -3.82e-01 | 0.219000 | 1.34e-02 | 0.15600 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 21 | 2.07e-02 | 2.22e-01 | 0.35900 | -3.14e-01 | 0.172000 | 1.27e-02 | 0.17200 |
| Condensation of Prometaphase Chromosomes | 10 | 2.23e-02 | 2.37e-01 | 0.50300 | 5.03e-01 | 0.000924 | 5.89e-03 | 0.99600 |
| MET promotes cell motility | 13 | 2.25e-02 | 2.37e-01 | 0.43000 | 2.58e-01 | 0.344000 | 1.07e-01 | 0.03160 |
| Inhibition of DNA recombination at telomere | 16 | 2.31e-02 | 2.40e-01 | 0.40300 | -3.80e-01 | 0.131000 | 8.44e-03 | 0.36400 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | 25 | 2.33e-02 | 2.41e-01 | 0.32400 | -1.80e-01 | 0.270000 | 1.20e-01 | 0.01960 |
| Cyclin A/B1/B2 associated events during G2/M transition | 21 | 2.46e-02 | 2.50e-01 | 0.34800 | 3.34e-01 | -0.097200 | 8.15e-03 | 0.44100 |
| PIP3 activates AKT signaling | 179 | 2.47e-02 | 2.50e-01 | 0.12100 | -1.09e-01 | 0.053100 | 1.27e-02 | 0.22300 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 82 | 2.50e-02 | 2.50e-01 | 0.17100 | 1.61e-01 | 0.056500 | 1.17e-02 | 0.37800 |
| Nicotinate metabolism | 19 | 2.51e-02 | 2.50e-01 | 0.36800 | 3.13e-01 | -0.194000 | 1.84e-02 | 0.14300 |
| Separation of Sister Chromatids | 145 | 2.67e-02 | 2.63e-01 | 0.13200 | 1.23e-01 | -0.049700 | 1.12e-02 | 0.30300 |
| Signaling by cytosolic FGFR1 fusion mutants | 18 | 2.95e-02 | 2.86e-01 | 0.35700 | 3.48e-01 | 0.081100 | 1.07e-02 | 0.55200 |
| HDR through Homologous Recombination (HRR) | 58 | 2.96e-02 | 2.86e-01 | 0.20200 | 2.02e-01 | -0.005730 | 7.98e-03 | 0.94000 |
| Mitotic Metaphase and Anaphase | 194 | 2.98e-02 | 2.86e-01 | 0.11300 | 1.03e-01 | -0.046900 | 1.40e-02 | 0.26300 |
| Post-translational modification: synthesis of GPI-anchored proteins | 28 | 3.36e-02 | 3.20e-01 | 0.28300 | 2.90e-02 | 0.281000 | 7.91e-01 | 0.01000 |
| Anchoring of the basal body to the plasma membrane | 80 | 3.42e-02 | 3.23e-01 | 0.16700 | 1.66e-01 | 0.022900 | 1.07e-02 | 0.72400 |
| Elevation of cytosolic Ca2+ levels | 10 | 3.45e-02 | 3.24e-01 | 0.46200 | -3.03e-01 | -0.348000 | 9.69e-02 | 0.05660 |
| NOD1/2 Signaling Pathway | 23 | 3.54e-02 | 3.29e-01 | 0.31900 | 2.60e-01 | -0.184000 | 3.08e-02 | 0.12700 |
| Regulation of FZD by ubiquitination | 11 | 3.64e-02 | 3.35e-01 | 0.45900 | -3.77e-01 | 0.262000 | 3.05e-02 | 0.13300 |
| COPI-dependent Golgi-to-ER retrograde traffic | 64 | 3.77e-02 | 3.44e-01 | 0.18100 | 1.18e-01 | 0.137000 | 1.03e-01 | 0.05880 |
| Mitotic Anaphase | 193 | 3.79e-02 | 3.44e-01 | 0.10900 | 9.95e-02 | -0.045600 | 1.78e-02 | 0.27800 |
| Chaperone Mediated Autophagy | 12 | 3.98e-02 | 3.52e-01 | 0.41500 | -3.75e-01 | -0.177000 | 2.44e-02 | 0.29000 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 14 | 4.02e-02 | 3.52e-01 | 0.38100 | 2.87e-01 | 0.251000 | 6.29e-02 | 0.10400 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 13 | 4.03e-02 | 3.52e-01 | 0.40100 | -3.91e-01 | -0.091200 | 1.48e-02 | 0.56900 |
| DNA Double-Strand Break Repair | 112 | 4.07e-02 | 3.52e-01 | 0.13700 | 1.32e-01 | 0.036400 | 1.61e-02 | 0.50800 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 19 | 4.12e-02 | 3.52e-01 | 0.34200 | -2.92e-01 | 0.179000 | 2.76e-02 | 0.17800 |
| RIPK1-mediated regulated necrosis | 13 | 4.14e-02 | 3.52e-01 | 0.41400 | 3.46e-01 | -0.227000 | 3.09e-02 | 0.15700 |
| Regulated Necrosis | 13 | 4.14e-02 | 3.52e-01 | 0.41400 | 3.46e-01 | -0.227000 | 3.09e-02 | 0.15700 |
| Senescence-Associated Secretory Phenotype (SASP) | 41 | 4.17e-02 | 3.52e-01 | 0.22700 | -2.27e-01 | -0.001250 | 1.18e-02 | 0.98900 |
| WNT5A-dependent internalization of FZD4 | 10 | 4.17e-02 | 3.52e-01 | 0.45600 | -4.47e-01 | -0.086400 | 1.43e-02 | 0.63600 |
| SUMOylation of transcription factors | 12 | 4.20e-02 | 3.52e-01 | 0.40900 | 2.72e-01 | 0.306000 | 1.03e-01 | 0.06690 |
| TNFR1-induced NFkappaB signaling pathway | 19 | 4.22e-02 | 3.52e-01 | 0.34000 | 1.37e-01 | -0.311000 | 3.02e-01 | 0.01910 |
| Signaling by WNT | 174 | 4.75e-02 | 3.90e-01 | 0.11100 | -3.97e-02 | 0.104000 | 3.69e-01 | 0.01920 |
| AURKA Activation by TPX2 | 59 | 4.75e-02 | 3.90e-01 | 0.18200 | 1.59e-01 | 0.087800 | 3.45e-02 | 0.24500 |
| NS1 Mediated Effects on Host Pathways | 38 | 4.88e-02 | 3.98e-01 | 0.22900 | 2.26e-01 | 0.035900 | 1.62e-02 | 0.70200 |
| Insulin processing | 17 | 4.92e-02 | 3.98e-01 | 0.34100 | 3.38e-01 | 0.048700 | 1.60e-02 | 0.72800 |
| Gene expression (Transcription) | 1006 | 5.12e-02 | 4.11e-01 | 0.04590 | 3.94e-02 | 0.023600 | 4.10e-02 | 0.22100 |
| Regulation of TP53 Activity through Phosphorylation | 76 | 5.18e-02 | 4.13e-01 | 0.16100 | 1.60e-01 | 0.013400 | 1.59e-02 | 0.84000 |
| G2/M Checkpoints | 115 | 5.22e-02 | 4.13e-01 | 0.13100 | 1.31e-01 | 0.009730 | 1.59e-02 | 0.85700 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 26 | 5.27e-02 | 4.15e-01 | 0.26800 | -1.57e-01 | -0.218000 | 1.67e-01 | 0.05480 |
| Ca2+ pathway | 39 | 5.32e-02 | 4.16e-01 | 0.21900 | 1.34e-01 | 0.173000 | 1.47e-01 | 0.06240 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 38 | 5.42e-02 | 4.18e-01 | 0.23200 | 1.90e-01 | -0.133000 | 4.29e-02 | 0.15600 |
| Signaling by FGFR1 in disease | 26 | 5.43e-02 | 4.18e-01 | 0.27100 | 2.65e-01 | 0.053800 | 1.93e-02 | 0.63500 |
| Deactivation of the beta-catenin transactivating complex | 28 | 5.51e-02 | 4.22e-01 | 0.26900 | -2.23e-01 | 0.150000 | 4.10e-02 | 0.16900 |
| Keratan sulfate/keratin metabolism | 19 | 5.59e-02 | 4.24e-01 | 0.32600 | -2.03e-01 | 0.256000 | 1.27e-01 | 0.05380 |
| PINK1-PRKN Mediated Mitophagy | 18 | 5.73e-02 | 4.24e-01 | 0.32400 | -3.22e-01 | -0.034400 | 1.82e-02 | 0.80000 |
| Platelet degranulation | 49 | 5.75e-02 | 4.24e-01 | 0.19900 | -1.97e-01 | 0.025700 | 1.72e-02 | 0.75600 |
| Nonhomologous End-Joining (NHEJ) | 28 | 5.88e-02 | 4.24e-01 | 0.25500 | 2.30e-01 | 0.109000 | 3.50e-02 | 0.31900 |
| Uptake and actions of bacterial toxins | 19 | 5.98e-02 | 4.24e-01 | 0.30700 | -2.15e-01 | -0.218000 | 1.05e-01 | 0.09940 |
| Nicotinamide salvaging | 11 | 5.99e-02 | 4.24e-01 | 0.42000 | 3.91e-01 | -0.155000 | 2.49e-02 | 0.37500 |
| Mitotic G2-G2/M phases | 156 | 5.99e-02 | 4.24e-01 | 0.11000 | 1.10e-01 | 0.006050 | 1.83e-02 | 0.89700 |
| Transcriptional Regulation by E2F6 | 29 | 6.06e-02 | 4.24e-01 | 0.26000 | 2.09e-01 | -0.155000 | 5.14e-02 | 0.14900 |
| RAB geranylgeranylation | 39 | 6.06e-02 | 4.24e-01 | 0.22300 | 8.37e-02 | -0.207000 | 3.66e-01 | 0.02560 |
| Cytokine Signaling in Immune system | 497 | 6.13e-02 | 4.24e-01 | 0.06340 | 6.24e-02 | -0.011000 | 1.90e-02 | 0.67900 |
| Recruitment of NuMA to mitotic centrosomes | 64 | 6.13e-02 | 4.24e-01 | 0.16700 | 1.04e-01 | 0.131000 | 1.52e-01 | 0.07110 |
| Ub-specific processing proteases | 131 | 6.15e-02 | 4.24e-01 | 0.12200 | 1.09e-01 | -0.055400 | 3.18e-02 | 0.27600 |
| Josephin domain DUBs | 10 | 6.17e-02 | 4.24e-01 | 0.42600 | -4.14e-01 | -0.101000 | 2.36e-02 | 0.58200 |
| Loss of Nlp from mitotic centrosomes | 56 | 6.17e-02 | 4.24e-01 | 0.17800 | 1.44e-01 | 0.105000 | 6.25e-02 | 0.17600 |
| Loss of proteins required for interphase microtubule organization from the centrosome | 56 | 6.17e-02 | 4.24e-01 | 0.17800 | 1.44e-01 | 0.105000 | 6.25e-02 | 0.17600 |
| Factors involved in megakaryocyte development and platelet production | 86 | 6.18e-02 | 4.24e-01 | 0.14400 | 1.10e-01 | 0.092500 | 7.84e-02 | 0.13900 |
| Assembly Of The HIV Virion | 14 | 6.19e-02 | 4.24e-01 | 0.36700 | -3.62e-01 | 0.061500 | 1.92e-02 | 0.69100 |
| Homology Directed Repair | 88 | 6.30e-02 | 4.26e-01 | 0.14300 | 1.38e-01 | 0.039400 | 2.59e-02 | 0.52400 |
| Glycogen storage diseases | 10 | 6.37e-02 | 4.26e-01 | 0.42700 | -4.26e-01 | -0.029400 | 1.98e-02 | 0.87200 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 6.38e-02 | 4.26e-01 | 0.37100 | 2.00e-01 | -0.312000 | 1.96e-01 | 0.04330 |
| EGFR downregulation | 20 | 6.39e-02 | 4.26e-01 | 0.30900 | -2.72e-01 | 0.147000 | 3.50e-02 | 0.25600 |
| Response to elevated platelet cytosolic Ca2+ | 53 | 6.43e-02 | 4.26e-01 | 0.18900 | -1.81e-01 | 0.053200 | 2.28e-02 | 0.50400 |
| HSF1 activation | 21 | 6.51e-02 | 4.26e-01 | 0.29100 | -2.84e-01 | -0.064100 | 2.43e-02 | 0.61100 |
| Cytochrome P450 - arranged by substrate type | 14 | 6.52e-02 | 4.26e-01 | 0.35700 | 3.51e-01 | 0.067600 | 2.32e-02 | 0.66200 |
| Muscle contraction | 66 | 6.54e-02 | 4.26e-01 | 0.16400 | -4.67e-02 | -0.157000 | 5.13e-01 | 0.02740 |
| FGFR1 mutant receptor activation | 21 | 6.56e-02 | 4.26e-01 | 0.28900 | 2.67e-01 | 0.109000 | 3.40e-02 | 0.38500 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 37 | 6.77e-02 | 4.33e-01 | 0.21700 | -6.76e-02 | -0.206000 | 4.77e-01 | 0.03000 |
| PTEN Regulation | 114 | 6.83e-02 | 4.33e-01 | 0.12600 | -1.26e-01 | 0.010300 | 2.06e-02 | 0.85000 |
| PIWI-interacting RNA (piRNA) biogenesis | 15 | 6.86e-02 | 4.33e-01 | 0.35100 | -3.25e-01 | 0.135000 | 2.96e-02 | 0.36700 |
| Cilium Assembly | 152 | 6.92e-02 | 4.33e-01 | 0.10700 | 1.03e-01 | 0.030700 | 2.91e-02 | 0.51500 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | 35 | 6.96e-02 | 4.33e-01 | 0.23000 | -2.11e-01 | 0.091300 | 3.10e-02 | 0.35000 |
| HIV Transcription Elongation | 35 | 6.96e-02 | 4.33e-01 | 0.23000 | -2.11e-01 | 0.091300 | 3.10e-02 | 0.35000 |
| Tat-mediated elongation of the HIV-1 transcript | 35 | 6.96e-02 | 4.33e-01 | 0.23000 | -2.11e-01 | 0.091300 | 3.10e-02 | 0.35000 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | 54 | 6.97e-02 | 4.33e-01 | 0.18300 | -1.82e-01 | 0.018200 | 2.11e-02 | 0.81700 |
| Sphingolipid metabolism | 50 | 7.07e-02 | 4.36e-01 | 0.18400 | 8.37e-02 | 0.164000 | 3.07e-01 | 0.04470 |
| Golgi-to-ER retrograde transport | 92 | 7.11e-02 | 4.37e-01 | 0.13600 | 1.05e-01 | 0.086300 | 8.39e-02 | 0.15400 |
| SHC1 events in ERBB2 signaling | 11 | 7.20e-02 | 4.40e-01 | 0.39300 | 1.19e-01 | 0.375000 | 4.94e-01 | 0.03140 |
| Signaling by MET | 42 | 7.26e-02 | 4.41e-01 | 0.19900 | 1.23e-01 | 0.157000 | 1.69e-01 | 0.07840 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 12 | 7.43e-02 | 4.48e-01 | 0.38900 | 3.30e-01 | -0.205000 | 4.78e-02 | 0.21800 |
| PI3K/AKT Signaling in Cancer | 48 | 7.46e-02 | 4.48e-01 | 0.19400 | -1.72e-01 | 0.090500 | 3.97e-02 | 0.27900 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | 24 | 7.50e-02 | 4.48e-01 | 0.27500 | -1.63e-01 | 0.222000 | 1.68e-01 | 0.06020 |
| Translation of structural proteins | 26 | 7.59e-02 | 4.51e-01 | 0.25300 | -2.38e-01 | -0.085700 | 3.57e-02 | 0.45000 |
| Organelle biogenesis and maintenance | 202 | 7.80e-02 | 4.60e-01 | 0.09070 | 8.00e-02 | 0.042800 | 5.14e-02 | 0.29800 |
| Metabolism of vitamins and cofactors | 107 | 7.82e-02 | 4.60e-01 | 0.12600 | 1.25e-01 | 0.011500 | 2.54e-02 | 0.83800 |
| Chondroitin sulfate/dermatan sulfate metabolism | 26 | 7.90e-02 | 4.62e-01 | 0.26200 | -1.74e-01 | 0.196000 | 1.25e-01 | 0.08450 |
| Detoxification of Reactive Oxygen Species | 23 | 8.01e-02 | 4.67e-01 | 0.27100 | -2.71e-01 | 0.017100 | 2.47e-02 | 0.88700 |
| Centrosome maturation | 65 | 8.16e-02 | 4.70e-01 | 0.15700 | 1.06e-01 | 0.116000 | 1.41e-01 | 0.10800 |
| Recruitment of mitotic centrosome proteins and complexes | 65 | 8.16e-02 | 4.70e-01 | 0.15700 | 1.06e-01 | 0.116000 | 1.41e-01 | 0.10800 |
| Mitochondrial tRNA aminoacylation | 18 | 8.28e-02 | 4.70e-01 | 0.30300 | -5.92e-03 | -0.303000 | 9.65e-01 | 0.02600 |
| Chromatin modifying enzymes | 150 | 8.29e-02 | 4.70e-01 | 0.10700 | -1.06e-01 | 0.011900 | 2.59e-02 | 0.80300 |
| Chromatin organization | 150 | 8.29e-02 | 4.70e-01 | 0.10700 | -1.06e-01 | 0.011900 | 2.59e-02 | 0.80300 |
| RMTs methylate histone arginines | 25 | 8.34e-02 | 4.70e-01 | 0.26300 | -2.35e-01 | 0.117000 | 4.19e-02 | 0.31100 |
| ER Quality Control Compartment (ERQC) | 18 | 8.36e-02 | 4.70e-01 | 0.29800 | -1.20e-01 | -0.272000 | 3.80e-01 | 0.04550 |
| G2/M Transition | 154 | 8.40e-02 | 4.70e-01 | 0.10400 | 1.04e-01 | 0.007290 | 2.71e-02 | 0.87700 |
| Processing of Capped Intronless Pre-mRNA | 21 | 8.47e-02 | 4.71e-01 | 0.28300 | -6.51e-02 | 0.276000 | 6.06e-01 | 0.02890 |
| Late endosomal microautophagy | 23 | 8.52e-02 | 4.72e-01 | 0.26600 | -2.66e-01 | -0.015200 | 2.73e-02 | 0.89900 |
| Signaling by TGF-beta Receptor Complex | 63 | 8.83e-02 | 4.85e-01 | 0.15700 | -1.07e-01 | -0.114000 | 1.43e-01 | 0.11700 |
| Glycogen synthesis | 11 | 8.84e-02 | 4.85e-01 | 0.38700 | -3.81e-01 | 0.067800 | 2.89e-02 | 0.69700 |
| RNA Polymerase II Transcription | 894 | 9.04e-02 | 4.91e-01 | 0.04350 | 3.82e-02 | 0.021000 | 6.03e-02 | 0.30100 |
| UCH proteinases | 74 | 9.04e-02 | 4.91e-01 | 0.14700 | -1.46e-01 | -0.013500 | 3.00e-02 | 0.84100 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 10 | 9.36e-02 | 5.00e-01 | 0.40700 | 3.17e-01 | -0.255000 | 8.25e-02 | 0.16200 |
| Formation of the Early Elongation Complex | 29 | 9.42e-02 | 5.00e-01 | 0.23900 | -1.85e-01 | 0.152000 | 8.54e-02 | 0.15700 |
| Formation of the HIV-1 Early Elongation Complex | 29 | 9.42e-02 | 5.00e-01 | 0.23900 | -1.85e-01 | 0.152000 | 8.54e-02 | 0.15700 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | 23 | 9.42e-02 | 5.00e-01 | 0.26300 | -2.62e-01 | 0.019300 | 2.98e-02 | 0.87300 |
| DNA Damage Recognition in GG-NER | 35 | 9.43e-02 | 5.00e-01 | 0.20800 | -1.85e-01 | -0.094400 | 5.80e-02 | 0.33400 |
| Meiotic recombination | 16 | 9.56e-02 | 5.04e-01 | 0.31800 | 2.95e-01 | -0.120000 | 4.11e-02 | 0.40800 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 45 | 9.71e-02 | 5.10e-01 | 0.18700 | 1.86e-01 | -0.013700 | 3.09e-02 | 0.87400 |
| Signaling by BMP | 14 | 9.83e-02 | 5.11e-01 | 0.33600 | 3.26e-01 | -0.081700 | 3.47e-02 | 0.59700 |
| Resolution of Abasic Sites (AP sites) | 30 | 9.83e-02 | 5.11e-01 | 0.22300 | -2.06e-01 | -0.086400 | 5.14e-02 | 0.41300 |
| Transcriptional regulation of granulopoiesis | 24 | 9.86e-02 | 5.11e-01 | 0.25400 | 2.54e-01 | -0.002840 | 3.15e-02 | 0.98100 |
| Base Excision Repair | 36 | 9.95e-02 | 5.11e-01 | 0.20500 | -2.00e-01 | -0.043800 | 3.81e-02 | 0.65000 |
| RNA polymerase II transcribes snRNA genes | 63 | 9.96e-02 | 5.11e-01 | 0.16000 | 1.42e-01 | -0.072800 | 5.11e-02 | 0.31800 |
| RHO GTPase Effectors | 183 | 1.01e-01 | 5.14e-01 | 0.09320 | 9.12e-02 | -0.019300 | 3.43e-02 | 0.65500 |
| Cell surface interactions at the vascular wall | 57 | 1.04e-01 | 5.26e-01 | 0.15900 | -8.76e-02 | -0.133000 | 2.54e-01 | 0.08230 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 46 | 1.04e-01 | 5.26e-01 | 0.17800 | -1.56e-01 | -0.085200 | 6.78e-02 | 0.31800 |
| Extension of Telomeres | 44 | 1.06e-01 | 5.36e-01 | 0.18800 | -1.70e-01 | 0.081000 | 5.15e-02 | 0.35300 |
| TNF signaling | 36 | 1.09e-01 | 5.41e-01 | 0.20500 | 3.84e-02 | -0.201000 | 6.91e-01 | 0.03690 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | 25 | 1.09e-01 | 5.41e-01 | 0.25000 | -1.68e-01 | 0.185000 | 1.46e-01 | 0.11000 |
| Attenuation phase | 19 | 1.09e-01 | 5.41e-01 | 0.27400 | -2.58e-01 | -0.092900 | 5.14e-02 | 0.48400 |
| Apoptotic execution phase | 33 | 1.11e-01 | 5.50e-01 | 0.21100 | 2.10e-01 | 0.006350 | 3.66e-02 | 0.95000 |
| Calnexin/calreticulin cycle | 23 | 1.12e-01 | 5.51e-01 | 0.24600 | -1.33e-01 | -0.207000 | 2.70e-01 | 0.08560 |
| Branched-chain amino acid catabolism | 19 | 1.13e-01 | 5.51e-01 | 0.28000 | 2.72e-01 | -0.063800 | 4.00e-02 | 0.63000 |
| Metabolism of water-soluble vitamins and cofactors | 79 | 1.13e-01 | 5.51e-01 | 0.13700 | 1.36e-01 | -0.016800 | 3.74e-02 | 0.79700 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 68 | 1.13e-01 | 5.51e-01 | 0.14700 | -1.47e-01 | 0.003950 | 3.70e-02 | 0.95500 |
| SUMOylation of immune response proteins | 10 | 1.14e-01 | 5.51e-01 | 0.39000 | -2.55e-01 | 0.296000 | 1.63e-01 | 0.10600 |
| Signaling by BRAF and RAF fusions | 42 | 1.15e-01 | 5.54e-01 | 0.18900 | 7.95e-02 | -0.172000 | 3.73e-01 | 0.05450 |
| Activation of ATR in response to replication stress | 33 | 1.16e-01 | 5.58e-01 | 0.20700 | 2.03e-01 | 0.038800 | 4.37e-02 | 0.70000 |
| Signaling by Rho GTPases | 257 | 1.18e-01 | 5.62e-01 | 0.07580 | 7.54e-02 | -0.008410 | 3.90e-02 | 0.81800 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 32 | 1.19e-01 | 5.62e-01 | 0.20800 | -1.97e-01 | -0.066500 | 5.43e-02 | 0.51600 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 46 | 1.19e-01 | 5.62e-01 | 0.17200 | 1.07e-01 | 0.135000 | 2.11e-01 | 0.11500 |
| Cardiac conduction | 42 | 1.21e-01 | 5.70e-01 | 0.18300 | 2.98e-04 | -0.183000 | 9.97e-01 | 0.04000 |
| Keratan sulfate biosynthesis | 15 | 1.23e-01 | 5.76e-01 | 0.31200 | -2.73e-01 | 0.151000 | 6.77e-02 | 0.31100 |
| Asymmetric localization of PCP proteins | 51 | 1.24e-01 | 5.76e-01 | 0.16500 | -1.65e-01 | -0.003420 | 4.15e-02 | 0.96600 |
| Regulation of PLK1 Activity at G2/M Transition | 74 | 1.25e-01 | 5.76e-01 | 0.13700 | 1.37e-01 | -0.003030 | 4.15e-02 | 0.96400 |
| Mitochondrial Fatty Acid Beta-Oxidation | 25 | 1.25e-01 | 5.76e-01 | 0.23800 | -4.12e-02 | 0.234000 | 7.22e-01 | 0.04300 |
| Mitophagy | 23 | 1.25e-01 | 5.76e-01 | 0.24700 | -2.45e-01 | 0.026100 | 4.18e-02 | 0.82900 |
| DNA Repair | 238 | 1.27e-01 | 5.76e-01 | 0.07530 | 6.43e-02 | 0.039100 | 8.99e-02 | 0.30200 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 20 | 1.27e-01 | 5.76e-01 | 0.26300 | 2.63e-01 | -0.011600 | 4.22e-02 | 0.92900 |
| Nucleosome assembly | 20 | 1.27e-01 | 5.76e-01 | 0.26300 | 2.63e-01 | -0.011600 | 4.22e-02 | 0.92900 |
| Platelet calcium homeostasis | 17 | 1.27e-01 | 5.76e-01 | 0.27800 | -1.60e-01 | -0.227000 | 2.55e-01 | 0.10500 |
| Constitutive Signaling by Aberrant PI3K in Cancer | 24 | 1.27e-01 | 5.76e-01 | 0.24500 | -1.87e-01 | 0.159000 | 1.13e-01 | 0.17800 |
| Formation of HIV elongation complex in the absence of HIV Tat | 36 | 1.28e-01 | 5.76e-01 | 0.19900 | -1.83e-01 | 0.078800 | 5.78e-02 | 0.41400 |
| TNFR2 non-canonical NF-kB pathway | 67 | 1.28e-01 | 5.76e-01 | 0.14000 | -8.36e-02 | -0.112000 | 2.38e-01 | 0.11300 |
| Metabolism of steroids | 81 | 1.29e-01 | 5.77e-01 | 0.12700 | 1.11e-01 | 0.061800 | 8.36e-02 | 0.33800 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 12 | 1.29e-01 | 5.77e-01 | 0.32900 | 2.21e-01 | 0.244000 | 1.86e-01 | 0.14400 |
| SUMOylation of ubiquitinylation proteins | 37 | 1.30e-01 | 5.77e-01 | 0.18900 | 1.74e-01 | 0.072900 | 6.75e-02 | 0.44300 |
| Maturation of nucleoprotein | 10 | 1.33e-01 | 5.83e-01 | 0.37500 | 3.22e-01 | -0.192000 | 7.77e-02 | 0.29300 |
| Trafficking and processing of endosomal TLR | 10 | 1.33e-01 | 5.83e-01 | 0.36100 | 1.06e-01 | 0.345000 | 5.61e-01 | 0.05860 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 10 | 1.33e-01 | 5.83e-01 | 0.36100 | 1.13e-01 | 0.343000 | 5.37e-01 | 0.06060 |
| alpha-linolenic acid (ALA) metabolism | 10 | 1.33e-01 | 5.83e-01 | 0.36100 | 1.13e-01 | 0.343000 | 5.37e-01 | 0.06060 |
| RAF activation | 28 | 1.34e-01 | 5.83e-01 | 0.21900 | 2.19e-01 | -0.006790 | 4.51e-02 | 0.95000 |
| Mitotic Prophase | 73 | 1.34e-01 | 5.83e-01 | 0.13900 | 1.14e-01 | -0.080100 | 9.37e-02 | 0.23800 |
| Nucleotide Excision Repair | 98 | 1.36e-01 | 5.86e-01 | 0.11800 | -1.17e-01 | 0.015400 | 4.63e-02 | 0.79300 |
| Neurexins and neuroligins | 20 | 1.38e-01 | 5.93e-01 | 0.26300 | -2.22e-01 | 0.141000 | 8.56e-02 | 0.27500 |
| RHO GTPases activate CIT | 14 | 1.40e-01 | 6.00e-01 | 0.31400 | 2.46e-01 | -0.195000 | 1.11e-01 | 0.20700 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 10 | 1.41e-01 | 6.01e-01 | 0.36400 | 3.61e-01 | -0.044500 | 4.82e-02 | 0.80800 |
| Cell-Cell communication | 47 | 1.41e-01 | 6.02e-01 | 0.16300 | -1.23e-01 | -0.107000 | 1.46e-01 | 0.20600 |
| Negative regulation of the PI3K/AKT network | 51 | 1.42e-01 | 6.04e-01 | 0.16400 | -1.16e-01 | 0.116000 | 1.53e-01 | 0.15200 |
| SUMOylation of DNA replication proteins | 43 | 1.43e-01 | 6.04e-01 | 0.17000 | 1.25e-01 | 0.115000 | 1.57e-01 | 0.19400 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 27 | 1.44e-01 | 6.06e-01 | 0.22500 | 1.51e-01 | -0.166000 | 1.75e-01 | 0.13500 |
| Purine salvage | 11 | 1.45e-01 | 6.09e-01 | 0.34900 | -1.57e-01 | 0.312000 | 3.68e-01 | 0.07350 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 17 | 1.46e-01 | 6.09e-01 | 0.27900 | -2.67e-01 | 0.081200 | 5.72e-02 | 0.56200 |
| Deubiquitination | 192 | 1.49e-01 | 6.19e-01 | 0.08360 | 7.70e-02 | -0.032700 | 6.75e-02 | 0.43800 |
| Beta-catenin independent WNT signaling | 105 | 1.50e-01 | 6.20e-01 | 0.11300 | -8.81e-02 | 0.071100 | 1.20e-01 | 0.21000 |
| Regulation of IFNG signaling | 13 | 1.51e-01 | 6.20e-01 | 0.30800 | 3.03e-01 | 0.057300 | 5.87e-02 | 0.72100 |
| Signaling by WNT in cancer | 22 | 1.51e-01 | 6.20e-01 | 0.23700 | 3.64e-02 | 0.235000 | 7.68e-01 | 0.05700 |
| MHC class II antigen presentation | 70 | 1.51e-01 | 6.20e-01 | 0.13100 | 8.20e-02 | 0.102000 | 2.37e-01 | 0.13900 |
| FCERI mediated Ca+2 mobilization | 25 | 1.52e-01 | 6.20e-01 | 0.22200 | 4.47e-02 | 0.218000 | 6.99e-01 | 0.05990 |
| Fatty acid metabolism | 102 | 1.55e-01 | 6.30e-01 | 0.11000 | 2.40e-02 | 0.107000 | 6.77e-01 | 0.06240 |
| Response of EIF2AK1 (HRI) to heme deficiency | 13 | 1.55e-01 | 6.30e-01 | 0.31500 | 2.82e-01 | -0.141000 | 7.81e-02 | 0.38100 |
| mTORC1-mediated signalling | 21 | 1.56e-01 | 6.30e-01 | 0.24600 | -2.39e-01 | 0.058700 | 5.84e-02 | 0.64200 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 56 | 1.58e-01 | 6.33e-01 | 0.14500 | -1.17e-01 | -0.086200 | 1.32e-01 | 0.26500 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 14 | 1.58e-01 | 6.33e-01 | 0.29600 | -2.96e-01 | 0.004940 | 5.50e-02 | 0.97400 |
| Sulfur amino acid metabolism | 15 | 1.59e-01 | 6.33e-01 | 0.28800 | -2.86e-01 | 0.034600 | 5.56e-02 | 0.81700 |
| FGFR2 mutant receptor activation | 15 | 1.59e-01 | 6.33e-01 | 0.29100 | -2.73e-01 | 0.099800 | 6.74e-02 | 0.50300 |
| Glycogen metabolism | 17 | 1.59e-01 | 6.33e-01 | 0.26200 | -2.23e-01 | -0.138000 | 1.11e-01 | 0.32600 |
| Synthesis of IP3 and IP4 in the cytosol | 15 | 1.61e-01 | 6.38e-01 | 0.29200 | -1.76e-01 | 0.233000 | 2.39e-01 | 0.11800 |
| TBC/RABGAPs | 38 | 1.63e-01 | 6.41e-01 | 0.18300 | -1.52e-01 | 0.102000 | 1.05e-01 | 0.27900 |
| Signaling by Nuclear Receptors | 147 | 1.65e-01 | 6.48e-01 | 0.09040 | -8.95e-02 | -0.012300 | 6.22e-02 | 0.79700 |
| Regulation of necroptotic cell death | 11 | 1.66e-01 | 6.48e-01 | 0.33800 | 2.82e-01 | -0.186000 | 1.05e-01 | 0.28600 |
| Meiosis | 38 | 1.66e-01 | 6.48e-01 | 0.18200 | 1.50e-01 | -0.102000 | 1.09e-01 | 0.27500 |
| Caspase activation via extrinsic apoptotic signalling pathway | 15 | 1.67e-01 | 6.48e-01 | 0.28900 | 2.48e-01 | -0.147000 | 9.60e-02 | 0.32500 |
| Dectin-1 mediated noncanonical NF-kB signaling | 52 | 1.69e-01 | 6.53e-01 | 0.14800 | -1.28e-01 | -0.074200 | 1.11e-01 | 0.35600 |
| DAG and IP3 signaling | 26 | 1.71e-01 | 6.53e-01 | 0.21200 | 1.21e-02 | 0.212000 | 9.15e-01 | 0.06160 |
| VxPx cargo-targeting to cilium | 16 | 1.71e-01 | 6.53e-01 | 0.27200 | 2.71e-01 | -0.015100 | 6.02e-02 | 0.91700 |
| Protein localization | 122 | 1.72e-01 | 6.53e-01 | 0.09860 | -9.86e-02 | -0.001850 | 6.10e-02 | 0.97200 |
| RNA Polymerase I Transcription Initiation | 41 | 1.72e-01 | 6.53e-01 | 0.17100 | -1.68e-01 | 0.032600 | 6.31e-02 | 0.71900 |
| Nucleobase biosynthesis | 10 | 1.72e-01 | 6.53e-01 | 0.33700 | -3.15e-01 | -0.119000 | 8.48e-02 | 0.51300 |
| Signaling by ERBB2 KD Mutants | 11 | 1.74e-01 | 6.53e-01 | 0.32000 | 9.88e-02 | 0.305000 | 5.71e-01 | 0.08020 |
| Cholesterol biosynthesis | 20 | 1.75e-01 | 6.53e-01 | 0.23600 | 1.20e-01 | 0.203000 | 3.52e-01 | 0.11600 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 14 | 1.75e-01 | 6.53e-01 | 0.28200 | -1.43e-01 | -0.243000 | 3.54e-01 | 0.11600 |
| Processing of Capped Intron-Containing Pre-mRNA | 191 | 1.75e-01 | 6.53e-01 | 0.07970 | -7.72e-02 | 0.019800 | 6.74e-02 | 0.63900 |
| Autophagy | 104 | 1.75e-01 | 6.53e-01 | 0.10500 | -1.01e-01 | -0.028000 | 7.61e-02 | 0.62300 |
| tRNA Aminoacylation | 23 | 1.76e-01 | 6.53e-01 | 0.22500 | 1.66e-02 | -0.225000 | 8.91e-01 | 0.06220 |
| Kinesins | 31 | 1.76e-01 | 6.53e-01 | 0.18900 | 1.58e-01 | 0.104000 | 1.29e-01 | 0.31700 |
| Oncogenic MAPK signaling | 56 | 1.76e-01 | 6.53e-01 | 0.14700 | 1.30e-01 | -0.068900 | 9.29e-02 | 0.37300 |
| TRAF3-dependent IRF activation pathway | 13 | 1.80e-01 | 6.64e-01 | 0.29000 | 2.41e-01 | 0.161000 | 1.33e-01 | 0.31400 |
| Cyclin D associated events in G1 | 41 | 1.81e-01 | 6.64e-01 | 0.17100 | 1.16e-01 | -0.126000 | 2.00e-01 | 0.16300 |
| G1 Phase | 41 | 1.81e-01 | 6.64e-01 | 0.17100 | 1.16e-01 | -0.126000 | 2.00e-01 | 0.16300 |
| Signaling by PDGFR in disease | 16 | 1.81e-01 | 6.64e-01 | 0.26300 | 2.49e-01 | 0.084600 | 8.52e-02 | 0.55800 |
| RHO GTPases Activate NADPH Oxidases | 14 | 1.82e-01 | 6.64e-01 | 0.28700 | -2.83e-01 | 0.051600 | 6.73e-02 | 0.73800 |
| Vesicle-mediated transport | 442 | 1.83e-01 | 6.64e-01 | 0.05060 | 2.91e-02 | 0.041400 | 3.01e-01 | 0.14100 |
| Regulation of TNFR1 signaling | 28 | 1.85e-01 | 6.71e-01 | 0.20100 | 1.25e-02 | -0.201000 | 9.09e-01 | 0.06620 |
| Generation of second messenger molecules | 16 | 1.86e-01 | 6.71e-01 | 0.25900 | -1.57e-01 | -0.206000 | 2.78e-01 | 0.15500 |
| NIK-->noncanonical NF-kB signaling | 51 | 1.87e-01 | 6.75e-01 | 0.14500 | -1.18e-01 | -0.083900 | 1.46e-01 | 0.30100 |
| SUMOylation of DNA methylation proteins | 14 | 1.88e-01 | 6.76e-01 | 0.28400 | -2.80e-01 | 0.049600 | 6.98e-02 | 0.74800 |
| Telomere Extension By Telomerase | 20 | 1.91e-01 | 6.83e-01 | 0.24100 | -1.83e-01 | 0.157000 | 1.57e-01 | 0.22500 |
| Condensation of Prophase Chromosomes | 11 | 1.91e-01 | 6.83e-01 | 0.32500 | 2.48e-01 | -0.209000 | 1.54e-01 | 0.23000 |
| Activation of gene expression by SREBF (SREBP) | 34 | 1.94e-01 | 6.90e-01 | 0.17800 | 1.94e-02 | 0.177000 | 8.45e-01 | 0.07380 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | 41 | 1.95e-01 | 6.90e-01 | 0.16000 | 1.42e-01 | 0.074300 | 1.17e-01 | 0.41100 |
| N-glycan antennae elongation in the medial/trans-Golgi | 17 | 1.96e-01 | 6.90e-01 | 0.25700 | -2.40e-01 | 0.090800 | 8.64e-02 | 0.51700 |
| Pre-NOTCH Processing in Golgi | 15 | 1.97e-01 | 6.90e-01 | 0.27500 | -1.75e-01 | 0.213000 | 2.41e-01 | 0.15400 |
| HIV Infection | 188 | 1.98e-01 | 6.90e-01 | 0.07840 | -6.49e-02 | 0.043900 | 1.27e-01 | 0.30200 |
| Vpu mediated degradation of CD4 | 44 | 1.98e-01 | 6.90e-01 | 0.15400 | -1.38e-01 | -0.068800 | 1.15e-01 | 0.43100 |
| CD28 dependent PI3K/Akt signaling | 18 | 1.98e-01 | 6.90e-01 | 0.24400 | -2.43e-01 | -0.019700 | 7.44e-02 | 0.88500 |
| Nephrin family interactions | 14 | 1.98e-01 | 6.90e-01 | 0.27100 | -2.23e-01 | -0.154000 | 1.48e-01 | 0.31900 |
| Host Interactions of HIV factors | 106 | 2.01e-01 | 6.92e-01 | 0.10300 | -9.13e-02 | 0.048000 | 1.06e-01 | 0.39500 |
| Transport of the SLBP Dependant Mature mRNA | 34 | 2.01e-01 | 6.92e-01 | 0.17400 | 1.59e-01 | 0.071500 | 1.09e-01 | 0.47100 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | 10 | 2.03e-01 | 6.92e-01 | 0.33300 | 2.88e-01 | -0.168000 | 1.15e-01 | 0.35800 |
| Platelet activation, signaling and aggregation | 133 | 2.04e-01 | 6.92e-01 | 0.09210 | -7.45e-02 | 0.054100 | 1.39e-01 | 0.28300 |
| Negative regulation of FGFR1 signaling | 17 | 2.04e-01 | 6.92e-01 | 0.24400 | -1.94e-01 | -0.148000 | 1.67e-01 | 0.29200 |
| Negative regulation of FGFR2 signaling | 17 | 2.04e-01 | 6.92e-01 | 0.24400 | -1.94e-01 | -0.148000 | 1.67e-01 | 0.29200 |
| Negative regulation of FGFR3 signaling | 17 | 2.04e-01 | 6.92e-01 | 0.24400 | -1.94e-01 | -0.148000 | 1.67e-01 | 0.29200 |
| Negative regulation of FGFR4 signaling | 17 | 2.04e-01 | 6.92e-01 | 0.24400 | -1.94e-01 | -0.148000 | 1.67e-01 | 0.29200 |
| Oxidative Stress Induced Senescence | 54 | 2.04e-01 | 6.92e-01 | 0.13700 | -7.62e-02 | -0.114000 | 3.34e-01 | 0.14800 |
| Regulation of TP53 Activity through Methylation | 17 | 2.06e-01 | 6.93e-01 | 0.24300 | -1.46e-01 | -0.195000 | 2.99e-01 | 0.16500 |
| Transport of Mature Transcript to Cytoplasm | 63 | 2.06e-01 | 6.93e-01 | 0.12700 | 1.14e-01 | 0.056000 | 1.18e-01 | 0.44300 |
| Leishmania infection | 109 | 2.09e-01 | 7.00e-01 | 0.10000 | -4.48e-02 | 0.089900 | 4.21e-01 | 0.10600 |
| N-Glycan antennae elongation | 11 | 2.11e-01 | 7.05e-01 | 0.30900 | -3.07e-01 | 0.035400 | 7.82e-02 | 0.83900 |
| Spry regulation of FGF signaling | 15 | 2.12e-01 | 7.07e-01 | 0.25600 | -2.02e-01 | -0.158000 | 1.76e-01 | 0.29000 |
| Synthesis of glycosylphosphatidylinositol (GPI) | 13 | 2.15e-01 | 7.15e-01 | 0.27800 | 6.15e-02 | 0.271000 | 7.01e-01 | 0.09130 |
| Telomere C-strand (Lagging Strand) Synthesis | 29 | 2.16e-01 | 7.15e-01 | 0.19100 | -1.80e-01 | 0.064500 | 9.43e-02 | 0.54800 |
| Regulation of RUNX3 expression and activity | 49 | 2.17e-01 | 7.15e-01 | 0.14100 | -8.66e-02 | -0.111000 | 2.95e-01 | 0.17800 |
| Plasma lipoprotein assembly, remodeling, and clearance | 32 | 2.17e-01 | 7.15e-01 | 0.18300 | -1.47e-01 | 0.109000 | 1.50e-01 | 0.28700 |
| RHO GTPases activate PKNs | 24 | 2.18e-01 | 7.16e-01 | 0.20200 | 1.79e-01 | 0.093500 | 1.30e-01 | 0.42800 |
| Lysosome Vesicle Biogenesis | 25 | 2.19e-01 | 7.17e-01 | 0.20600 | -1.72e-01 | 0.114000 | 1.37e-01 | 0.32600 |
| HDACs deacetylate histones | 28 | 2.21e-01 | 7.22e-01 | 0.19100 | -1.88e-01 | 0.033000 | 8.46e-02 | 0.76200 |
| Gluconeogenesis | 24 | 2.23e-01 | 7.24e-01 | 0.20600 | -2.03e-01 | 0.038100 | 8.59e-02 | 0.74700 |
| Membrane Trafficking | 436 | 2.23e-01 | 7.24e-01 | 0.04790 | 2.70e-02 | 0.039600 | 3.41e-01 | 0.16200 |
| RNA Polymerase II Transcription Termination | 42 | 2.24e-01 | 7.24e-01 | 0.15400 | 1.66e-02 | 0.153000 | 8.52e-01 | 0.08740 |
| RHO GTPases activate PAKs | 13 | 2.25e-01 | 7.25e-01 | 0.28100 | 2.67e-01 | -0.087500 | 9.58e-02 | 0.58500 |
| SARS-CoV Infections | 69 | 2.25e-01 | 7.25e-01 | 0.11900 | -1.15e-01 | -0.030600 | 9.99e-02 | 0.66100 |
| Polo-like kinase mediated events | 14 | 2.26e-01 | 7.25e-01 | 0.26800 | 2.66e-01 | -0.028900 | 8.50e-02 | 0.85100 |
| Reproduction | 43 | 2.27e-01 | 7.25e-01 | 0.15600 | 1.05e-01 | -0.115000 | 2.33e-01 | 0.19300 |
| Transport of Mature mRNA Derived from an Intronless Transcript | 40 | 2.28e-01 | 7.25e-01 | 0.15400 | 1.42e-01 | 0.059700 | 1.20e-01 | 0.51400 |
| SUMOylation of DNA damage response and repair proteins | 67 | 2.28e-01 | 7.25e-01 | 0.11900 | 1.02e-01 | 0.061500 | 1.51e-01 | 0.38500 |
| VEGFR2 mediated vascular permeability | 22 | 2.29e-01 | 7.25e-01 | 0.21400 | -5.74e-02 | 0.206000 | 6.42e-01 | 0.09400 |
| Early Phase of HIV Life Cycle | 13 | 2.29e-01 | 7.25e-01 | 0.28100 | -1.51e-01 | 0.238000 | 3.47e-01 | 0.13800 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 43 | 2.32e-01 | 7.30e-01 | 0.14700 | -1.27e-01 | -0.075500 | 1.51e-01 | 0.39200 |
| Neutrophil degranulation | 306 | 2.33e-01 | 7.30e-01 | 0.05600 | -4.86e-02 | -0.028000 | 1.48e-01 | 0.40500 |
| Transport of the SLBP independent Mature mRNA | 33 | 2.33e-01 | 7.30e-01 | 0.16900 | 1.60e-01 | 0.053700 | 1.11e-01 | 0.59400 |
| Transport of Ribonucleoproteins into the Host Nucleus | 30 | 2.33e-01 | 7.30e-01 | 0.17700 | 1.60e-01 | 0.074900 | 1.30e-01 | 0.47800 |
| RNA Polymerase III Chain Elongation | 16 | 2.35e-01 | 7.31e-01 | 0.25200 | -1.88e-01 | 0.167000 | 1.92e-01 | 0.24600 |
| Formation of the beta-catenin:TCF transactivating complex | 24 | 2.35e-01 | 7.31e-01 | 0.20500 | -9.18e-02 | 0.183000 | 4.37e-01 | 0.12100 |
| G beta:gamma signalling through CDC42 | 12 | 2.36e-01 | 7.31e-01 | 0.27600 | 2.24e-01 | 0.162000 | 1.80e-01 | 0.33000 |
| ABC transporter disorders | 56 | 2.36e-01 | 7.31e-01 | 0.13000 | -1.29e-01 | -0.018600 | 9.54e-02 | 0.81000 |
| Signal Transduction | 1173 | 2.37e-01 | 7.32e-01 | 0.03100 | -9.20e-03 | 0.029600 | 6.10e-01 | 0.10100 |
| Collagen biosynthesis and modifying enzymes | 17 | 2.38e-01 | 7.32e-01 | 0.23400 | -2.20e-01 | -0.078900 | 1.17e-01 | 0.57300 |
| Amino acids regulate mTORC1 | 43 | 2.40e-01 | 7.35e-01 | 0.15300 | -1.07e-01 | 0.109000 | 2.25e-01 | 0.21700 |
| HATs acetylate histones | 58 | 2.40e-01 | 7.35e-01 | 0.12900 | -1.28e-01 | 0.021100 | 9.34e-02 | 0.78200 |
| MicroRNA (miRNA) biogenesis | 20 | 2.41e-01 | 7.35e-01 | 0.22200 | -2.07e-01 | 0.079800 | 1.09e-01 | 0.53700 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | 55 | 2.41e-01 | 7.35e-01 | 0.13400 | 1.21e-01 | -0.057900 | 1.21e-01 | 0.45800 |
| FLT3 Signaling | 167 | 2.43e-01 | 7.36e-01 | 0.07570 | -7.56e-02 | -0.002130 | 9.34e-02 | 0.96200 |
| Diseases of carbohydrate metabolism | 22 | 2.43e-01 | 7.36e-01 | 0.20900 | -2.06e-01 | 0.030800 | 9.41e-02 | 0.80300 |
| NOTCH1 Intracellular Domain Regulates Transcription | 37 | 2.46e-01 | 7.41e-01 | 0.16000 | -1.59e-01 | 0.015100 | 9.42e-02 | 0.87400 |
| RNA Polymerase I Promoter Clearance | 44 | 2.48e-01 | 7.41e-01 | 0.14500 | -1.45e-01 | -0.008780 | 9.67e-02 | 0.92000 |
| RNA Polymerase I Transcription | 44 | 2.48e-01 | 7.41e-01 | 0.14500 | -1.45e-01 | -0.008780 | 9.67e-02 | 0.92000 |
| Signaling by ERBB2 ECD mutants | 10 | 2.48e-01 | 7.41e-01 | 0.29800 | 1.74e-01 | 0.241000 | 3.40e-01 | 0.18700 |
| Membrane binding and targetting of GAG proteins | 12 | 2.49e-01 | 7.41e-01 | 0.27600 | -2.72e-01 | -0.043200 | 1.03e-01 | 0.79600 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 12 | 2.49e-01 | 7.41e-01 | 0.27600 | -2.72e-01 | -0.043200 | 1.03e-01 | 0.79600 |
| Phosphorylation of CD3 and TCR zeta chains | 10 | 2.49e-01 | 7.41e-01 | 0.29800 | -1.43e-01 | -0.261000 | 4.33e-01 | 0.15300 |
| DCC mediated attractive signaling | 11 | 2.50e-01 | 7.41e-01 | 0.29200 | -3.90e-02 | 0.289000 | 8.23e-01 | 0.09700 |
| Metabolism of cofactors | 17 | 2.51e-01 | 7.44e-01 | 0.23400 | 2.33e-01 | -0.020700 | 9.68e-02 | 0.88200 |
| Synthesis of PC | 19 | 2.53e-01 | 7.44e-01 | 0.21400 | 1.74e-01 | 0.125000 | 1.90e-01 | 0.34400 |
| Formation of TC-NER Pre-Incision Complex | 45 | 2.54e-01 | 7.44e-01 | 0.14200 | -1.40e-01 | -0.021000 | 1.04e-01 | 0.80800 |
| Polymerase switching on the C-strand of the telomere | 22 | 2.54e-01 | 7.44e-01 | 0.20700 | -1.98e-01 | 0.057600 | 1.07e-01 | 0.64000 |
| Budding and maturation of HIV virion | 24 | 2.54e-01 | 7.44e-01 | 0.19300 | -1.91e-01 | -0.033000 | 1.06e-01 | 0.78000 |
| Degradation of DVL | 48 | 2.56e-01 | 7.46e-01 | 0.13600 | -1.32e-01 | -0.032700 | 1.14e-01 | 0.69600 |
| Caspase activation via Death Receptors in the presence of ligand | 10 | 2.56e-01 | 7.46e-01 | 0.30900 | 2.30e-01 | -0.207000 | 2.08e-01 | 0.25800 |
| TGF-beta receptor signaling activates SMADs | 32 | 2.58e-01 | 7.47e-01 | 0.16700 | -1.64e-01 | -0.031400 | 1.10e-01 | 0.75900 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | 22 | 2.58e-01 | 7.47e-01 | 0.20100 | -2.98e-02 | -0.199000 | 8.09e-01 | 0.10600 |
| Notch-HLH transcription pathway | 21 | 2.58e-01 | 7.47e-01 | 0.20800 | -2.07e-01 | 0.024500 | 1.01e-01 | 0.84600 |
| Nuclear Receptor transcription pathway | 26 | 2.59e-01 | 7.47e-01 | 0.18900 | -1.76e-01 | 0.070200 | 1.21e-01 | 0.53600 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 23 | 2.61e-01 | 7.50e-01 | 0.19400 | 1.84e-01 | 0.062500 | 1.27e-01 | 0.60400 |
| TCR signaling | 88 | 2.61e-01 | 7.50e-01 | 0.09880 | -7.82e-02 | -0.060300 | 2.06e-01 | 0.33000 |
| Cellular Senescence | 105 | 2.63e-01 | 7.53e-01 | 0.09130 | -8.84e-02 | -0.023000 | 1.19e-01 | 0.68500 |
| Initiation of Nuclear Envelope (NE) Reformation | 17 | 2.65e-01 | 7.56e-01 | 0.23200 | 2.19e-01 | -0.076700 | 1.19e-01 | 0.58400 |
| Peroxisomal lipid metabolism | 22 | 2.67e-01 | 7.57e-01 | 0.19500 | 1.52e-01 | 0.122000 | 2.16e-01 | 0.32200 |
| TP53 Regulates Metabolic Genes | 72 | 2.67e-01 | 7.57e-01 | 0.10800 | -5.26e-02 | -0.094900 | 4.41e-01 | 0.16500 |
| Constitutive Signaling by EGFRvIII | 10 | 2.68e-01 | 7.57e-01 | 0.28900 | 1.68e-01 | 0.235000 | 3.57e-01 | 0.19800 |
| Signaling by EGFRvIII in Cancer | 10 | 2.68e-01 | 7.57e-01 | 0.28900 | 1.68e-01 | 0.235000 | 3.57e-01 | 0.19800 |
| Processive synthesis on the C-strand of the telomere | 17 | 2.69e-01 | 7.57e-01 | 0.22800 | -2.27e-01 | 0.025200 | 1.06e-01 | 0.85700 |
| Translesion synthesis by REV1 | 14 | 2.70e-01 | 7.57e-01 | 0.25500 | -2.20e-01 | 0.129000 | 1.54e-01 | 0.40300 |
| Glycerophospholipid biosynthesis | 71 | 2.70e-01 | 7.57e-01 | 0.11200 | -1.73e-02 | 0.111000 | 8.01e-01 | 0.10800 |
| SARS-CoV-1 Infection | 43 | 2.72e-01 | 7.59e-01 | 0.14100 | -1.37e-01 | -0.032100 | 1.21e-01 | 0.71600 |
| Ubiquitin-dependent degradation of Cyclin D | 44 | 2.73e-01 | 7.60e-01 | 0.13800 | -1.30e-01 | -0.046000 | 1.35e-01 | 0.59800 |
| Negative regulators of DDX58/IFIH1 signaling | 33 | 2.73e-01 | 7.60e-01 | 0.16600 | 1.15e-01 | -0.120000 | 2.52e-01 | 0.23400 |
| Translesion Synthesis by POLH | 16 | 2.74e-01 | 7.62e-01 | 0.23700 | -2.14e-01 | 0.102000 | 1.39e-01 | 0.48000 |
| Immune System | 1198 | 2.75e-01 | 7.62e-01 | 0.02880 | 2.86e-02 | -0.003460 | 1.09e-01 | 0.84700 |
| Signaling by Receptor Tyrosine Kinases | 284 | 2.78e-01 | 7.66e-01 | 0.05700 | -3.82e-02 | 0.042300 | 2.72e-01 | 0.22400 |
| Dual incision in TC-NER | 55 | 2.79e-01 | 7.66e-01 | 0.12500 | -1.25e-01 | 0.015400 | 1.11e-01 | 0.84400 |
| Signaling by EGFR in Cancer | 16 | 2.79e-01 | 7.66e-01 | 0.23600 | -1.41e-01 | 0.190000 | 3.30e-01 | 0.18900 |
| p75NTR signals via NF-kB | 11 | 2.81e-01 | 7.70e-01 | 0.27400 | -2.66e-01 | -0.066700 | 1.27e-01 | 0.70200 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 19 | 2.84e-01 | 7.75e-01 | 0.21400 | -2.03e-01 | 0.067300 | 1.26e-01 | 0.61200 |
| Telomere C-strand synthesis initiation | 10 | 2.86e-01 | 7.76e-01 | 0.29500 | -1.37e-01 | 0.261000 | 4.52e-01 | 0.15300 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | 22 | 2.87e-01 | 7.76e-01 | 0.19900 | -1.75e-01 | 0.093700 | 1.55e-01 | 0.44700 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 155 | 2.88e-01 | 7.76e-01 | 0.07200 | 5.83e-02 | 0.042300 | 2.13e-01 | 0.36500 |
| Response of Mtb to phagocytosis | 20 | 2.88e-01 | 7.76e-01 | 0.19900 | -1.34e-01 | -0.147000 | 3.00e-01 | 0.25600 |
| Erythropoietin activates RAS | 11 | 2.88e-01 | 7.76e-01 | 0.27100 | 7.09e-02 | 0.261000 | 6.84e-01 | 0.13300 |
| Regulation of IFNA signaling | 12 | 2.88e-01 | 7.76e-01 | 0.26900 | 1.59e-01 | -0.217000 | 3.40e-01 | 0.19300 |
| Downstream TCR signaling | 72 | 2.89e-01 | 7.76e-01 | 0.10600 | -9.70e-02 | -0.041800 | 1.56e-01 | 0.54100 |
| Hedgehog 'off' state | 75 | 2.93e-01 | 7.85e-01 | 0.10200 | -8.59e-02 | -0.055700 | 1.99e-01 | 0.40500 |
| ABC-family proteins mediated transport | 72 | 2.93e-01 | 7.85e-01 | 0.10400 | -8.71e-02 | -0.057700 | 2.02e-01 | 0.39900 |
| Downregulation of TGF-beta receptor signaling | 26 | 2.94e-01 | 7.86e-01 | 0.17300 | -1.15e-01 | -0.129000 | 3.10e-01 | 0.25600 |
| Apoptotic cleavage of cellular proteins | 25 | 2.97e-01 | 7.90e-01 | 0.18000 | 1.80e-01 | 0.004910 | 1.20e-01 | 0.96600 |
| Suppression of phagosomal maturation | 12 | 2.98e-01 | 7.91e-01 | 0.25300 | -1.84e-01 | -0.173000 | 2.69e-01 | 0.30000 |
| Macroautophagy | 95 | 2.99e-01 | 7.91e-01 | 0.09100 | -8.63e-02 | -0.029000 | 1.47e-01 | 0.62600 |
| Dopamine Neurotransmitter Release Cycle | 12 | 2.99e-01 | 7.91e-01 | 0.26500 | -2.04e-01 | 0.170000 | 2.22e-01 | 0.30700 |
| Constitutive Signaling by AKT1 E17K in Cancer | 23 | 3.00e-01 | 7.91e-01 | 0.18800 | -1.87e-01 | 0.023700 | 1.22e-01 | 0.84400 |
| Circadian Clock | 50 | 3.02e-01 | 7.96e-01 | 0.12700 | -6.75e-03 | 0.127000 | 9.34e-01 | 0.12200 |
| Class I MHC mediated antigen processing & presentation | 281 | 3.04e-01 | 7.98e-01 | 0.05360 | 5.31e-02 | 0.006980 | 1.29e-01 | 0.84200 |
| APC-Cdc20 mediated degradation of Nek2A | 24 | 3.08e-01 | 8.07e-01 | 0.17900 | -4.38e-02 | -0.173000 | 7.10e-01 | 0.14200 |
| Downregulation of ERBB2 signaling | 15 | 3.09e-01 | 8.07e-01 | 0.22800 | -2.28e-01 | -0.002820 | 1.26e-01 | 0.98500 |
| Signaling by FGFR2 IIIa TM | 14 | 3.11e-01 | 8.12e-01 | 0.23900 | -2.31e-01 | 0.061600 | 1.35e-01 | 0.69000 |
| Translesion synthesis by POLI | 15 | 3.13e-01 | 8.14e-01 | 0.23300 | -1.52e-01 | 0.177000 | 3.09e-01 | 0.23600 |
| Synthesis of PIPs at the early endosome membrane | 12 | 3.14e-01 | 8.14e-01 | 0.26000 | 2.17e-01 | -0.143000 | 1.94e-01 | 0.39100 |
| Amino acid transport across the plasma membrane | 16 | 3.17e-01 | 8.21e-01 | 0.22100 | 4.59e-02 | -0.216000 | 7.51e-01 | 0.13500 |
| Deadenylation of mRNA | 21 | 3.18e-01 | 8.21e-01 | 0.19300 | 1.85e-01 | -0.055600 | 1.42e-01 | 0.65900 |
| Purine catabolism | 11 | 3.20e-01 | 8.21e-01 | 0.27000 | -2.07e-01 | 0.173000 | 2.35e-01 | 0.32200 |
| Signaling by NOTCH4 | 68 | 3.21e-01 | 8.21e-01 | 0.10300 | -6.61e-02 | -0.079300 | 3.47e-01 | 0.25900 |
| APC/C:Cdc20 mediated degradation of Securin | 58 | 3.22e-01 | 8.21e-01 | 0.11200 | -9.43e-02 | -0.060200 | 2.15e-01 | 0.42900 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 28 | 3.22e-01 | 8.21e-01 | 0.16600 | -4.39e-02 | 0.160000 | 6.88e-01 | 0.14200 |
| Nuclear Envelope Breakdown | 49 | 3.23e-01 | 8.21e-01 | 0.12300 | 1.19e-01 | 0.029900 | 1.50e-01 | 0.71800 |
| Assembly and cell surface presentation of NMDA receptors | 12 | 3.23e-01 | 8.21e-01 | 0.25700 | -1.61e-01 | 0.200000 | 3.35e-01 | 0.22900 |
| Nuclear signaling by ERBB4 | 16 | 3.23e-01 | 8.21e-01 | 0.21500 | -4.61e-02 | -0.210000 | 7.50e-01 | 0.14700 |
| NRAGE signals death through JNK | 31 | 3.24e-01 | 8.23e-01 | 0.15600 | -8.74e-03 | 0.156000 | 9.33e-01 | 0.13300 |
| Metabolism of nucleotides | 69 | 3.26e-01 | 8.24e-01 | 0.10500 | -1.04e-01 | 0.005960 | 1.34e-01 | 0.93200 |
| Cell junction organization | 25 | 3.26e-01 | 8.24e-01 | 0.17000 | -1.54e-01 | -0.070200 | 1.82e-01 | 0.54400 |
| Signaling by TGFB family members | 73 | 3.29e-01 | 8.27e-01 | 0.09890 | -4.93e-02 | -0.085700 | 4.67e-01 | 0.20600 |
| activated TAK1 mediates p38 MAPK activation | 13 | 3.29e-01 | 8.27e-01 | 0.24500 | 1.78e-01 | -0.168000 | 2.67e-01 | 0.29300 |
| Transport of vitamins, nucleosides, and related molecules | 21 | 3.31e-01 | 8.30e-01 | 0.19200 | -1.07e-01 | 0.159000 | 3.99e-01 | 0.20600 |
| Plasma lipoprotein clearance | 19 | 3.32e-01 | 8.30e-01 | 0.20000 | -1.91e-01 | 0.058900 | 1.51e-01 | 0.65700 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 42 | 3.32e-01 | 8.30e-01 | 0.12900 | -1.10e-01 | -0.067800 | 2.17e-01 | 0.44800 |
| NGF-stimulated transcription | 25 | 3.34e-01 | 8.31e-01 | 0.16800 | -1.53e-01 | -0.069900 | 1.87e-01 | 0.54600 |
| Collagen formation | 27 | 3.34e-01 | 8.31e-01 | 0.16900 | -1.30e-01 | 0.108000 | 2.42e-01 | 0.33400 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | 54 | 3.36e-01 | 8.31e-01 | 0.11500 | 1.09e-01 | 0.034300 | 1.65e-01 | 0.66300 |
| Programmed Cell Death | 134 | 3.36e-01 | 8.31e-01 | 0.07600 | 5.03e-02 | -0.057000 | 3.17e-01 | 0.25700 |
| Degradation of GLI2 by the proteasome | 50 | 3.37e-01 | 8.31e-01 | 0.11800 | -9.66e-02 | -0.067400 | 2.38e-01 | 0.41000 |
| GLI3 is processed to GLI3R by the proteasome | 50 | 3.37e-01 | 8.31e-01 | 0.11800 | -9.66e-02 | -0.067400 | 2.38e-01 | 0.41000 |
| Processing of Intronless Pre-mRNAs | 14 | 3.39e-01 | 8.32e-01 | 0.22200 | 1.07e-01 | 0.195000 | 4.87e-01 | 0.20800 |
| Uptake and function of anthrax toxins | 10 | 3.39e-01 | 8.32e-01 | 0.26200 | -2.11e-01 | -0.155000 | 2.47e-01 | 0.39700 |
| mRNA 3'-end processing | 35 | 3.41e-01 | 8.35e-01 | 0.14000 | 1.02e-01 | 0.095400 | 2.96e-01 | 0.32900 |
| Post-translational protein modification | 889 | 3.42e-01 | 8.37e-01 | 0.02940 | 2.83e-02 | 0.007990 | 1.65e-01 | 0.69500 |
| RAF/MAP kinase cascade | 156 | 3.44e-01 | 8.37e-01 | 0.06880 | -6.72e-02 | 0.015000 | 1.50e-01 | 0.74800 |
| Defective CFTR causes cystic fibrosis | 52 | 3.44e-01 | 8.37e-01 | 0.11600 | -1.12e-01 | -0.030600 | 1.65e-01 | 0.70400 |
| Inactivation, recovery and regulation of the phototransduction cascade | 16 | 3.48e-01 | 8.41e-01 | 0.20500 | 1.15e-01 | 0.170000 | 4.26e-01 | 0.24000 |
| The phototransduction cascade | 16 | 3.48e-01 | 8.41e-01 | 0.20500 | 1.15e-01 | 0.170000 | 4.26e-01 | 0.24000 |
| Chromosome Maintenance | 74 | 3.48e-01 | 8.41e-01 | 0.10000 | -8.81e-02 | 0.047300 | 1.91e-01 | 0.48300 |
| Ion transport by P-type ATPases | 27 | 3.52e-01 | 8.47e-01 | 0.16400 | 8.42e-02 | -0.141000 | 4.49e-01 | 0.20500 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 45 | 3.52e-01 | 8.47e-01 | 0.12800 | -9.20e-02 | 0.088700 | 2.86e-01 | 0.30400 |
| Removal of the Flap Intermediate from the C-strand | 15 | 3.54e-01 | 8.47e-01 | 0.21700 | -2.11e-01 | 0.054300 | 1.58e-01 | 0.71600 |
| Base-Excision Repair, AP Site Formation | 13 | 3.54e-01 | 8.47e-01 | 0.22600 | -1.95e-01 | -0.114000 | 2.25e-01 | 0.47600 |
| Role of phospholipids in phagocytosis | 16 | 3.54e-01 | 8.47e-01 | 0.20900 | -2.05e-02 | 0.208000 | 8.87e-01 | 0.15000 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 16 | 3.56e-01 | 8.49e-01 | 0.20900 | -2.05e-01 | 0.043800 | 1.56e-01 | 0.76200 |
| PI3K Cascade | 18 | 3.58e-01 | 8.49e-01 | 0.19200 | -1.82e-01 | -0.062000 | 1.82e-01 | 0.64900 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 44 | 3.59e-01 | 8.49e-01 | 0.12200 | -1.05e-01 | -0.062800 | 2.31e-01 | 0.47200 |
| p53-Independent DNA Damage Response | 44 | 3.59e-01 | 8.49e-01 | 0.12200 | -1.05e-01 | -0.062800 | 2.31e-01 | 0.47200 |
| p53-Independent G1/S DNA damage checkpoint | 44 | 3.59e-01 | 8.49e-01 | 0.12200 | -1.05e-01 | -0.062800 | 2.31e-01 | 0.47200 |
| SCF-beta-TrCP mediated degradation of Emi1 | 47 | 3.61e-01 | 8.49e-01 | 0.11800 | -9.81e-02 | -0.065000 | 2.45e-01 | 0.44200 |
| Disorders of developmental biology | 10 | 3.62e-01 | 8.49e-01 | 0.25400 | -1.84e-01 | -0.175000 | 3.14e-01 | 0.33800 |
| Loss of function of MECP2 in Rett syndrome | 10 | 3.62e-01 | 8.49e-01 | 0.25400 | -1.84e-01 | -0.175000 | 3.14e-01 | 0.33800 |
| Pervasive developmental disorders | 10 | 3.62e-01 | 8.49e-01 | 0.25400 | -1.84e-01 | -0.175000 | 3.14e-01 | 0.33800 |
| Retrograde transport at the Trans-Golgi-Network | 45 | 3.65e-01 | 8.53e-01 | 0.12400 | 1.20e-01 | -0.031200 | 1.65e-01 | 0.71800 |
| Other semaphorin interactions | 10 | 3.66e-01 | 8.53e-01 | 0.25700 | -3.76e-02 | -0.254000 | 8.37e-01 | 0.16400 |
| Regulation of signaling by CBL | 14 | 3.66e-01 | 8.53e-01 | 0.22400 | -1.51e-01 | 0.166000 | 3.28e-01 | 0.28300 |
| Protein-protein interactions at synapses | 32 | 3.67e-01 | 8.53e-01 | 0.14400 | -1.44e-01 | -0.003140 | 1.58e-01 | 0.97500 |
| IRS-related events triggered by IGF1R | 22 | 3.68e-01 | 8.53e-01 | 0.17000 | -1.29e-01 | -0.111000 | 2.95e-01 | 0.37000 |
| APC/C:Cdc20 mediated degradation of Cyclin B | 22 | 3.68e-01 | 8.53e-01 | 0.17000 | -8.08e-02 | -0.150000 | 5.12e-01 | 0.22400 |
| CTLA4 inhibitory signaling | 16 | 3.69e-01 | 8.53e-01 | 0.20100 | -4.61e-02 | -0.196000 | 7.50e-01 | 0.17500 |
| RHO GTPases Activate ROCKs | 13 | 3.70e-01 | 8.53e-01 | 0.23200 | 1.66e-01 | -0.162000 | 3.02e-01 | 0.31100 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | 12 | 3.70e-01 | 8.53e-01 | 0.23100 | -8.04e-02 | -0.216000 | 6.30e-01 | 0.19400 |
| EPHB-mediated forward signaling | 25 | 3.72e-01 | 8.55e-01 | 0.16200 | 1.62e-01 | 0.009390 | 1.62e-01 | 0.93500 |
| Stabilization of p53 | 48 | 3.73e-01 | 8.55e-01 | 0.11500 | -5.98e-02 | -0.097800 | 4.75e-01 | 0.24200 |
| Synaptic adhesion-like molecules | 10 | 3.73e-01 | 8.55e-01 | 0.25000 | -1.53e-01 | -0.197000 | 4.01e-01 | 0.28000 |
| Interconversion of nucleotide di- and triphosphates | 22 | 3.75e-01 | 8.56e-01 | 0.16800 | -1.04e-01 | -0.132000 | 3.98e-01 | 0.28300 |
| Regulation of beta-cell development | 14 | 3.77e-01 | 8.59e-01 | 0.21700 | -2.14e-01 | 0.037200 | 1.66e-01 | 0.81000 |
| O-linked glycosylation | 42 | 3.78e-01 | 8.60e-01 | 0.12500 | -1.24e-01 | 0.018700 | 1.65e-01 | 0.83500 |
| Beta-catenin phosphorylation cascade | 15 | 3.82e-01 | 8.66e-01 | 0.20400 | 4.81e-02 | 0.199000 | 7.47e-01 | 0.18300 |
| Termination of O-glycan biosynthesis | 10 | 3.83e-01 | 8.68e-01 | 0.25100 | -2.49e-01 | -0.033300 | 1.73e-01 | 0.85600 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 77 | 3.87e-01 | 8.76e-01 | 0.08890 | -7.58e-02 | -0.046400 | 2.51e-01 | 0.48300 |
| Metabolism of polyamines | 48 | 3.89e-01 | 8.78e-01 | 0.11200 | -9.16e-02 | -0.064500 | 2.73e-01 | 0.44000 |
| Signaling by ERBB2 in Cancer | 12 | 3.92e-01 | 8.80e-01 | 0.22300 | 9.81e-02 | 0.201000 | 5.57e-01 | 0.22900 |
| Estrogen-dependent gene expression | 68 | 3.94e-01 | 8.80e-01 | 0.09810 | -8.38e-02 | 0.051100 | 2.33e-01 | 0.46700 |
| Triglyceride metabolism | 16 | 3.94e-01 | 8.80e-01 | 0.19400 | 7.21e-02 | 0.180000 | 6.18e-01 | 0.21400 |
| NEP/NS2 Interacts with the Cellular Export Machinery | 30 | 3.95e-01 | 8.80e-01 | 0.14200 | 1.34e-01 | 0.044900 | 2.04e-01 | 0.67100 |
| Disorders of transmembrane transporters | 105 | 3.96e-01 | 8.80e-01 | 0.07560 | -6.83e-02 | -0.032500 | 2.28e-01 | 0.56600 |
| RNA Polymerase III Transcription Initiation | 33 | 3.96e-01 | 8.80e-01 | 0.14000 | -8.24e-02 | 0.114000 | 4.13e-01 | 0.25900 |
| Generic Transcription Pathway | 802 | 3.98e-01 | 8.80e-01 | 0.02820 | 2.04e-02 | 0.019500 | 3.39e-01 | 0.36100 |
| Negative regulation of NOTCH4 signaling | 48 | 3.98e-01 | 8.80e-01 | 0.11100 | -9.46e-02 | -0.057700 | 2.58e-01 | 0.49000 |
| TP53 Regulates Transcription of DNA Repair Genes | 51 | 3.98e-01 | 8.80e-01 | 0.11200 | -1.03e-01 | 0.043600 | 2.03e-01 | 0.59100 |
| Activation of NF-kappaB in B cells | 57 | 3.99e-01 | 8.80e-01 | 0.10200 | -8.96e-02 | -0.048200 | 2.43e-01 | 0.53000 |
| Cytosolic sulfonation of small molecules | 10 | 3.99e-01 | 8.80e-01 | 0.24700 | -2.46e-01 | -0.015400 | 1.78e-01 | 0.93300 |
| Mitotic G1 phase and G1/S transition | 127 | 4.01e-01 | 8.83e-01 | 0.07140 | 5.71e-02 | -0.043000 | 2.69e-01 | 0.40500 |
| TP53 Regulates Transcription of Cell Cycle Genes | 42 | 4.02e-01 | 8.83e-01 | 0.12400 | 9.48e-02 | -0.079300 | 2.88e-01 | 0.37500 |
| Extracellular matrix organization | 91 | 4.02e-01 | 8.83e-01 | 0.08320 | -7.90e-02 | 0.026200 | 1.94e-01 | 0.66700 |
| TP53 Regulates Transcription of Cell Death Genes | 30 | 4.03e-01 | 8.83e-01 | 0.14500 | 1.26e-01 | -0.071900 | 2.31e-01 | 0.49600 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 20 | 4.05e-01 | 8.84e-01 | 0.17100 | -1.65e-01 | -0.044900 | 2.01e-01 | 0.72800 |
| Degradation of AXIN | 47 | 4.05e-01 | 8.84e-01 | 0.11100 | -1.02e-01 | -0.043700 | 2.25e-01 | 0.60500 |
| SUMO E3 ligases SUMOylate target proteins | 131 | 4.07e-01 | 8.87e-01 | 0.06790 | 1.21e-03 | 0.067900 | 9.81e-01 | 0.18100 |
| Signaling by EGFR | 36 | 4.09e-01 | 8.87e-01 | 0.13000 | -1.27e-01 | 0.029800 | 1.88e-01 | 0.75700 |
| Selective autophagy | 48 | 4.09e-01 | 8.87e-01 | 0.11100 | -1.11e-01 | -0.002050 | 1.82e-01 | 0.98000 |
| Anti-inflammatory response favouring Leishmania parasite infection | 51 | 4.10e-01 | 8.87e-01 | 0.11100 | -5.44e-02 | 0.096200 | 5.02e-01 | 0.23500 |
| Leishmania parasite growth and survival | 51 | 4.10e-01 | 8.87e-01 | 0.11100 | -5.44e-02 | 0.096200 | 5.02e-01 | 0.23500 |
| CLEC7A (Dectin-1) induces NFAT activation | 11 | 4.11e-01 | 8.87e-01 | 0.23000 | 3.83e-02 | 0.227000 | 8.26e-01 | 0.19300 |
| Phospholipid metabolism | 129 | 4.12e-01 | 8.87e-01 | 0.06940 | -2.62e-02 | 0.064200 | 6.09e-01 | 0.21000 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 33 | 4.15e-01 | 8.90e-01 | 0.13400 | -1.50e-02 | 0.133000 | 8.81e-01 | 0.18600 |
| Translesion synthesis by POLK | 15 | 4.17e-01 | 8.90e-01 | 0.20200 | -1.40e-01 | 0.146000 | 3.49e-01 | 0.32700 |
| Assembly of collagen fibrils and other multimeric structures | 14 | 4.17e-01 | 8.90e-01 | 0.20100 | 5.79e-02 | 0.193000 | 7.08e-01 | 0.21200 |
| Signaling by NTRK2 (TRKB) | 16 | 4.18e-01 | 8.90e-01 | 0.18600 | 1.46e-01 | 0.115000 | 3.11e-01 | 0.42700 |
| Smooth Muscle Contraction | 19 | 4.19e-01 | 8.90e-01 | 0.17200 | -1.63e-01 | -0.054300 | 2.18e-01 | 0.68200 |
| Regulation of TP53 Degradation | 32 | 4.19e-01 | 8.90e-01 | 0.13100 | -8.49e-02 | -0.100000 | 4.06e-01 | 0.32700 |
| Regulation of TP53 Expression and Degradation | 33 | 4.21e-01 | 8.90e-01 | 0.12900 | -8.72e-02 | -0.095200 | 3.87e-01 | 0.34400 |
| Cleavage of the damaged pyrimidine | 12 | 4.21e-01 | 8.90e-01 | 0.21400 | -1.61e-01 | -0.140000 | 3.33e-01 | 0.40100 |
| Depyrimidination | 12 | 4.21e-01 | 8.90e-01 | 0.21400 | -1.61e-01 | -0.140000 | 3.33e-01 | 0.40100 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 12 | 4.21e-01 | 8.90e-01 | 0.21400 | -1.61e-01 | -0.140000 | 3.33e-01 | 0.40100 |
| Apoptotic factor-mediated response | 14 | 4.23e-01 | 8.91e-01 | 0.20400 | 3.98e-02 | -0.201000 | 7.96e-01 | 0.19400 |
| Pre-NOTCH Expression and Processing | 41 | 4.27e-01 | 8.91e-01 | 0.11600 | 5.15e-02 | 0.103000 | 5.69e-01 | 0.25300 |
| FOXO-mediated transcription of cell death genes | 14 | 4.29e-01 | 8.91e-01 | 0.20400 | -1.90e-01 | 0.073800 | 2.18e-01 | 0.63300 |
| Signalling to ERKs | 26 | 4.30e-01 | 8.91e-01 | 0.15100 | 1.06e-01 | -0.107000 | 3.48e-01 | 0.34400 |
| Signaling by RAF1 mutants | 25 | 4.30e-01 | 8.91e-01 | 0.15100 | 1.27e-02 | -0.150000 | 9.12e-01 | 0.19400 |
| ERK/MAPK targets | 17 | 4.30e-01 | 8.91e-01 | 0.18200 | -4.34e-03 | 0.182000 | 9.75e-01 | 0.19400 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 11 | 4.31e-01 | 8.91e-01 | 0.22300 | 2.18e-01 | 0.049500 | 2.11e-01 | 0.77600 |
| Nucleotide salvage | 18 | 4.32e-01 | 8.91e-01 | 0.18100 | -1.34e-01 | 0.122000 | 3.25e-01 | 0.37200 |
| Interleukin-35 Signalling | 11 | 4.32e-01 | 8.91e-01 | 0.22200 | 2.09e-01 | 0.073100 | 2.29e-01 | 0.67500 |
| Interleukin-1 signaling | 78 | 4.32e-01 | 8.91e-01 | 0.08310 | -4.07e-02 | -0.072500 | 5.35e-01 | 0.27000 |
| Signaling by the B Cell Receptor (BCR) | 91 | 4.33e-01 | 8.91e-01 | 0.07810 | -7.74e-02 | -0.010500 | 2.03e-01 | 0.86300 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 16 | 4.33e-01 | 8.91e-01 | 0.18900 | 1.85e-01 | -0.037500 | 2.01e-01 | 0.79500 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 16 | 4.33e-01 | 8.91e-01 | 0.18900 | 1.85e-01 | -0.037500 | 2.01e-01 | 0.79500 |
| Zinc transporters | 11 | 4.34e-01 | 8.91e-01 | 0.22600 | 2.87e-02 | -0.225000 | 8.69e-01 | 0.19700 |
| G1/S-Specific Transcription | 25 | 4.34e-01 | 8.91e-01 | 0.15300 | 1.03e-01 | -0.114000 | 3.74e-01 | 0.32600 |
| Interleukin-12 signaling | 35 | 4.37e-01 | 8.96e-01 | 0.12800 | -5.47e-02 | 0.116000 | 5.76e-01 | 0.23600 |
| Pre-NOTCH Transcription and Translation | 27 | 4.40e-01 | 9.00e-01 | 0.14200 | 1.42e-01 | 0.007010 | 2.03e-01 | 0.95000 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 19 | 4.41e-01 | 9.00e-01 | 0.17400 | -1.40e-01 | 0.103000 | 2.91e-01 | 0.43800 |
| SUMOylation of transcription cofactors | 35 | 4.44e-01 | 9.00e-01 | 0.12800 | -8.54e-02 | 0.095100 | 3.83e-01 | 0.33100 |
| Signaling by FGFR2 | 47 | 4.48e-01 | 9.00e-01 | 0.10800 | -1.06e-01 | 0.017700 | 2.08e-01 | 0.83400 |
| Death Receptor Signalling | 96 | 4.49e-01 | 9.00e-01 | 0.07690 | 5.37e-02 | -0.055000 | 3.64e-01 | 0.35300 |
| Oncogene Induced Senescence | 30 | 4.49e-01 | 9.00e-01 | 0.13100 | -5.04e-02 | -0.121000 | 6.33e-01 | 0.25100 |
| GAB1 signalosome | 10 | 4.49e-01 | 9.00e-01 | 0.23500 | -2.15e-01 | 0.096700 | 2.40e-01 | 0.59700 |
| Synthesis of bile acids and bile salts | 13 | 4.49e-01 | 9.00e-01 | 0.20400 | 2.01e-01 | -0.035300 | 2.09e-01 | 0.82600 |
| MTOR signalling | 36 | 4.50e-01 | 9.00e-01 | 0.12500 | -9.00e-02 | 0.086700 | 3.51e-01 | 0.36900 |
| Interactions of Vpr with host cellular proteins | 33 | 4.50e-01 | 9.00e-01 | 0.12400 | 9.29e-02 | 0.082000 | 3.56e-01 | 0.41500 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 62 | 4.51e-01 | 9.00e-01 | 0.09060 | -5.24e-02 | -0.073900 | 4.76e-01 | 0.31500 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 12 | 4.51e-01 | 9.00e-01 | 0.20500 | -1.63e-01 | -0.125000 | 3.29e-01 | 0.45300 |
| G alpha (q) signalling events | 73 | 4.51e-01 | 9.00e-01 | 0.08750 | -4.62e-02 | 0.074300 | 4.96e-01 | 0.27300 |
| Formation of RNA Pol II elongation complex | 48 | 4.54e-01 | 9.00e-01 | 0.10800 | -7.90e-02 | 0.073100 | 3.44e-01 | 0.38200 |
| RNA Polymerase II Transcription Elongation | 48 | 4.54e-01 | 9.00e-01 | 0.10800 | -7.90e-02 | 0.073100 | 3.44e-01 | 0.38200 |
| MAPK1/MAPK3 signaling | 161 | 4.56e-01 | 9.00e-01 | 0.05830 | -5.60e-02 | 0.016000 | 2.22e-01 | 0.72800 |
| Platelet homeostasis | 48 | 4.56e-01 | 9.00e-01 | 0.10400 | -6.44e-03 | -0.104000 | 9.39e-01 | 0.21300 |
| Interleukin-15 signaling | 12 | 4.56e-01 | 9.00e-01 | 0.20400 | 1.22e-01 | 0.163000 | 4.64e-01 | 0.32800 |
| Degradation of beta-catenin by the destruction complex | 68 | 4.57e-01 | 9.00e-01 | 0.08930 | -8.38e-02 | 0.030700 | 2.33e-01 | 0.66200 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 53 | 4.58e-01 | 9.00e-01 | 0.09690 | -6.93e-02 | -0.067700 | 3.84e-01 | 0.39500 |
| PCNA-Dependent Long Patch Base Excision Repair | 18 | 4.59e-01 | 9.00e-01 | 0.17200 | -1.68e-01 | 0.034500 | 2.17e-01 | 0.80000 |
| Cellular response to hypoxia | 60 | 4.59e-01 | 9.00e-01 | 0.09100 | -6.85e-02 | -0.059800 | 3.60e-01 | 0.42400 |
| DNA Damage/Telomere Stress Induced Senescence | 23 | 4.60e-01 | 9.00e-01 | 0.14900 | 2.03e-02 | 0.148000 | 8.66e-01 | 0.22100 |
| DAP12 signaling | 21 | 4.62e-01 | 9.00e-01 | 0.15600 | 3.55e-03 | 0.156000 | 9.78e-01 | 0.21500 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | 15 | 4.62e-01 | 9.00e-01 | 0.18100 | -1.21e-01 | -0.134000 | 4.17e-01 | 0.36900 |
| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | 47 | 4.62e-01 | 9.00e-01 | 0.10300 | -9.40e-02 | -0.041700 | 2.66e-01 | 0.62100 |
| NCAM signaling for neurite out-growth | 22 | 4.63e-01 | 9.00e-01 | 0.15400 | 2.03e-02 | -0.152000 | 8.69e-01 | 0.21600 |
| SUMOylation of chromatin organization proteins | 49 | 4.64e-01 | 9.00e-01 | 0.10100 | 2.10e-02 | 0.099100 | 7.99e-01 | 0.23100 |
| ADP signalling through P2Y purinoceptor 1 | 15 | 4.64e-01 | 9.00e-01 | 0.18000 | 1.49e-01 | 0.102000 | 3.19e-01 | 0.49400 |
| Signaling by Retinoic Acid | 17 | 4.67e-01 | 9.00e-01 | 0.17000 | -6.80e-02 | -0.155000 | 6.28e-01 | 0.26700 |
| Nuclear Pore Complex (NPC) Disassembly | 34 | 4.68e-01 | 9.00e-01 | 0.12200 | 1.22e-01 | -0.002220 | 2.18e-01 | 0.98200 |
| Signaling by high-kinase activity BRAF mutants | 22 | 4.68e-01 | 9.00e-01 | 0.15100 | -1.50e-02 | -0.150000 | 9.03e-01 | 0.22300 |
| Hh mutants abrogate ligand secretion | 48 | 4.69e-01 | 9.00e-01 | 0.10100 | -9.76e-02 | -0.027500 | 2.43e-01 | 0.74200 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 28 | 4.70e-01 | 9.00e-01 | 0.13200 | 1.24e-01 | 0.045500 | 2.57e-01 | 0.67700 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | 28 | 4.70e-01 | 9.00e-01 | 0.13200 | 1.24e-01 | 0.045500 | 2.57e-01 | 0.67700 |
| Regulation of APC/C activators between G1/S and early anaphase | 70 | 4.71e-01 | 9.00e-01 | 0.08330 | -3.33e-02 | -0.076400 | 6.31e-01 | 0.27000 |
| Fanconi Anemia Pathway | 28 | 4.72e-01 | 9.00e-01 | 0.13100 | 5.41e-02 | 0.120000 | 6.20e-01 | 0.27400 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 63 | 4.72e-01 | 9.00e-01 | 0.08750 | -4.10e-02 | -0.077300 | 5.75e-01 | 0.28900 |
| Nuclear Events (kinase and transcription factor activation) | 43 | 4.73e-01 | 9.00e-01 | 0.10900 | -1.07e-01 | 0.019600 | 2.25e-01 | 0.82400 |
| Positive epigenetic regulation of rRNA expression | 40 | 4.74e-01 | 9.00e-01 | 0.11200 | -1.12e-01 | 0.011500 | 2.22e-01 | 0.90000 |
| Neuronal System | 130 | 4.75e-01 | 9.00e-01 | 0.06190 | -6.17e-02 | -0.004940 | 2.27e-01 | 0.92300 |
| CaM pathway | 20 | 4.76e-01 | 9.00e-01 | 0.15900 | -2.98e-02 | 0.156000 | 8.18e-01 | 0.22800 |
| Calmodulin induced events | 20 | 4.76e-01 | 9.00e-01 | 0.15900 | -2.98e-02 | 0.156000 | 8.18e-01 | 0.22800 |
| RAS processing | 15 | 4.77e-01 | 9.00e-01 | 0.17900 | -1.69e-01 | -0.057100 | 2.57e-01 | 0.70200 |
| G alpha (12/13) signalling events | 40 | 4.79e-01 | 9.00e-01 | 0.10900 | 5.54e-02 | 0.093300 | 5.45e-01 | 0.30800 |
| Signaling by FGFR in disease | 40 | 4.83e-01 | 9.00e-01 | 0.10800 | 9.18e-02 | 0.056700 | 3.16e-01 | 0.53600 |
| CDK-mediated phosphorylation and removal of Cdc6 | 62 | 4.83e-01 | 9.00e-01 | 0.08680 | -7.67e-02 | -0.040800 | 2.97e-01 | 0.58000 |
| Formation of Incision Complex in GG-NER | 36 | 4.86e-01 | 9.00e-01 | 0.11300 | 9.62e-02 | 0.059500 | 3.19e-01 | 0.53700 |
| Vif-mediated degradation of APOBEC3G | 43 | 4.87e-01 | 9.00e-01 | 0.10400 | -9.62e-02 | -0.039400 | 2.76e-01 | 0.65500 |
| HIV Life Cycle | 127 | 4.87e-01 | 9.00e-01 | 0.06350 | -4.62e-02 | 0.043500 | 3.71e-01 | 0.39900 |
| Syndecan interactions | 10 | 4.87e-01 | 9.00e-01 | 0.21500 | -1.96e-01 | -0.086600 | 2.82e-01 | 0.63500 |
| RNA Pol II CTD phosphorylation and interaction with CE | 23 | 4.88e-01 | 9.00e-01 | 0.14600 | -1.42e-01 | 0.032100 | 2.38e-01 | 0.79000 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 23 | 4.88e-01 | 9.00e-01 | 0.14600 | -1.42e-01 | 0.032100 | 2.38e-01 | 0.79000 |
| DNA Damage Bypass | 41 | 4.90e-01 | 9.00e-01 | 0.10600 | 5.43e-02 | 0.090500 | 5.48e-01 | 0.31700 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | 41 | 4.92e-01 | 9.00e-01 | 0.10700 | -7.72e-03 | -0.107000 | 9.32e-01 | 0.23700 |
| Downstream signaling of activated FGFR1 | 12 | 4.95e-01 | 9.00e-01 | 0.19300 | 1.32e-01 | 0.141000 | 4.30e-01 | 0.39900 |
| Downstream signaling of activated FGFR2 | 12 | 4.95e-01 | 9.00e-01 | 0.19300 | 1.32e-01 | 0.141000 | 4.30e-01 | 0.39900 |
| Downstream signaling of activated FGFR3 | 12 | 4.95e-01 | 9.00e-01 | 0.19300 | 1.32e-01 | 0.141000 | 4.30e-01 | 0.39900 |
| Downstream signaling of activated FGFR4 | 12 | 4.95e-01 | 9.00e-01 | 0.19300 | 1.32e-01 | 0.141000 | 4.30e-01 | 0.39900 |
| ESR-mediated signaling | 112 | 4.96e-01 | 9.00e-01 | 0.06570 | -6.34e-02 | 0.017300 | 2.48e-01 | 0.75300 |
| Interleukin-7 signaling | 14 | 4.96e-01 | 9.00e-01 | 0.18400 | -2.31e-02 | 0.182000 | 8.81e-01 | 0.23800 |
| FCERI mediated NF-kB activation | 64 | 4.97e-01 | 9.00e-01 | 0.08480 | -8.34e-02 | -0.015500 | 2.50e-01 | 0.83100 |
| Signaling by GPCR | 230 | 4.98e-01 | 9.00e-01 | 0.04630 | -1.82e-02 | 0.042600 | 6.37e-01 | 0.27000 |
| Degradation of GLI1 by the proteasome | 51 | 4.99e-01 | 9.00e-01 | 0.09320 | -7.28e-02 | -0.058200 | 3.69e-01 | 0.47300 |
| Stimuli-sensing channels | 39 | 4.99e-01 | 9.00e-01 | 0.10700 | 3.55e-02 | 0.101000 | 7.02e-01 | 0.27400 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 63 | 4.99e-01 | 9.00e-01 | 0.08690 | -2.08e-02 | 0.084400 | 7.75e-01 | 0.24700 |
| FGFR2 alternative splicing | 21 | 5.01e-01 | 9.00e-01 | 0.15100 | -1.34e-01 | 0.070400 | 2.88e-01 | 0.57700 |
| Signaling by SCF-KIT | 33 | 5.02e-01 | 9.00e-01 | 0.11900 | 1.18e-01 | -0.012700 | 2.41e-01 | 0.90000 |
| Netrin-1 signaling | 25 | 5.03e-01 | 9.00e-01 | 0.13500 | 8.42e-03 | 0.135000 | 9.42e-01 | 0.24400 |
| RUNX3 regulates p14-ARF | 10 | 5.05e-01 | 9.00e-01 | 0.21600 | 2.07e-01 | -0.062800 | 2.57e-01 | 0.73100 |
| Depolymerisation of the Nuclear Lamina | 13 | 5.06e-01 | 9.00e-01 | 0.18300 | 1.59e-01 | 0.090900 | 3.23e-01 | 0.57100 |
| Basigin interactions | 14 | 5.07e-01 | 9.00e-01 | 0.17600 | -9.72e-02 | -0.146000 | 5.29e-01 | 0.34300 |
| Signal transduction by L1 | 11 | 5.07e-01 | 9.00e-01 | 0.20300 | -9.02e-03 | 0.203000 | 9.59e-01 | 0.24400 |
| DAP12 interactions | 23 | 5.08e-01 | 9.00e-01 | 0.14000 | -1.23e-03 | 0.140000 | 9.92e-01 | 0.24500 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 19 | 5.08e-01 | 9.00e-01 | 0.15200 | 3.24e-02 | 0.149000 | 8.07e-01 | 0.26100 |
| Neurodegenerative Diseases | 19 | 5.08e-01 | 9.00e-01 | 0.15200 | 3.24e-02 | 0.149000 | 8.07e-01 | 0.26100 |
| Processive synthesis on the lagging strand | 13 | 5.10e-01 | 9.00e-01 | 0.18100 | -1.07e-01 | -0.146000 | 5.03e-01 | 0.36100 |
| Clathrin-mediated endocytosis | 90 | 5.10e-01 | 9.00e-01 | 0.07270 | -4.74e-02 | 0.055100 | 4.38e-01 | 0.36700 |
| Aggrephagy | 18 | 5.10e-01 | 9.00e-01 | 0.15800 | -1.58e-01 | -0.003620 | 2.47e-01 | 0.97900 |
| SUMOylation | 137 | 5.11e-01 | 9.00e-01 | 0.05690 | 1.38e-02 | 0.055200 | 7.81e-01 | 0.26700 |
| Misspliced GSK3beta mutants stabilize beta-catenin | 13 | 5.11e-01 | 9.00e-01 | 0.18100 | 1.40e-01 | 0.114000 | 3.81e-01 | 0.47500 |
| S33 mutants of beta-catenin aren't phosphorylated | 13 | 5.11e-01 | 9.00e-01 | 0.18100 | 1.40e-01 | 0.114000 | 3.81e-01 | 0.47500 |
| S37 mutants of beta-catenin aren't phosphorylated | 13 | 5.11e-01 | 9.00e-01 | 0.18100 | 1.40e-01 | 0.114000 | 3.81e-01 | 0.47500 |
| S45 mutants of beta-catenin aren't phosphorylated | 13 | 5.11e-01 | 9.00e-01 | 0.18100 | 1.40e-01 | 0.114000 | 3.81e-01 | 0.47500 |
| T41 mutants of beta-catenin aren't phosphorylated | 13 | 5.11e-01 | 9.00e-01 | 0.18100 | 1.40e-01 | 0.114000 | 3.81e-01 | 0.47500 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | 13 | 5.11e-01 | 9.00e-01 | 0.18100 | 1.40e-01 | 0.114000 | 3.81e-01 | 0.47500 |
| Metabolism of fat-soluble vitamins | 12 | 5.11e-01 | 9.00e-01 | 0.19700 | -8.70e-02 | 0.177000 | 6.02e-01 | 0.29000 |
| Interactions of Rev with host cellular proteins | 34 | 5.16e-01 | 9.00e-01 | 0.11100 | 8.08e-02 | 0.076400 | 4.15e-01 | 0.44200 |
| Mitochondrial calcium ion transport | 18 | 5.17e-01 | 9.00e-01 | 0.15300 | -1.37e-01 | -0.068400 | 3.14e-01 | 0.61600 |
| Inflammasomes | 16 | 5.18e-01 | 9.00e-01 | 0.17000 | 1.32e-01 | -0.107000 | 3.61e-01 | 0.46000 |
| GPCR downstream signalling | 215 | 5.18e-01 | 9.00e-01 | 0.04660 | -2.08e-02 | 0.041700 | 6.01e-01 | 0.29600 |
| Inositol phosphate metabolism | 29 | 5.18e-01 | 9.00e-01 | 0.12600 | -7.92e-02 | 0.098200 | 4.61e-01 | 0.36100 |
| ECM proteoglycans | 12 | 5.20e-01 | 9.00e-01 | 0.18700 | 1.63e-01 | 0.091000 | 3.29e-01 | 0.58500 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 27 | 5.21e-01 | 9.00e-01 | 0.12400 | -7.38e-02 | -0.099500 | 5.07e-01 | 0.37100 |
| Cargo recognition for clathrin-mediated endocytosis | 65 | 5.23e-01 | 9.00e-01 | 0.08360 | -7.23e-02 | 0.042100 | 3.15e-01 | 0.55800 |
| Apoptosis | 131 | 5.23e-01 | 9.00e-01 | 0.05920 | 3.73e-02 | -0.046000 | 4.63e-01 | 0.36500 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | 19 | 5.25e-01 | 9.00e-01 | 0.15200 | 4.33e-02 | -0.146000 | 7.44e-01 | 0.27000 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 19 | 5.25e-01 | 9.00e-01 | 0.15200 | 4.33e-02 | -0.146000 | 7.44e-01 | 0.27000 |
| Activated NOTCH1 Transmits Signal to the Nucleus | 19 | 5.27e-01 | 9.00e-01 | 0.14600 | -9.61e-02 | -0.110000 | 4.68e-01 | 0.40500 |
| Gastrin-CREB signalling pathway via PKC and MAPK | 12 | 5.27e-01 | 9.00e-01 | 0.19300 | -1.17e-01 | 0.154000 | 4.84e-01 | 0.35600 |
| Export of Viral Ribonucleoproteins from Nucleus | 31 | 5.28e-01 | 9.00e-01 | 0.11600 | 1.13e-01 | 0.024900 | 2.75e-01 | 0.81100 |
| G1/S Transition | 113 | 5.30e-01 | 9.00e-01 | 0.06310 | 4.27e-02 | -0.046500 | 4.35e-01 | 0.39500 |
| Interleukin-20 family signaling | 13 | 5.30e-01 | 9.00e-01 | 0.18500 | 1.48e-01 | -0.110000 | 3.55e-01 | 0.49200 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 65 | 5.32e-01 | 9.00e-01 | 0.07920 | -3.21e-02 | -0.072400 | 6.55e-01 | 0.31400 |
| ER-Phagosome pathway | 68 | 5.33e-01 | 9.00e-01 | 0.07710 | -3.81e-02 | -0.067000 | 5.88e-01 | 0.34000 |
| Platelet sensitization by LDL | 13 | 5.34e-01 | 9.00e-01 | 0.18000 | 1.79e-01 | -0.017000 | 2.63e-01 | 0.91500 |
| Metabolic disorders of biological oxidation enzymes | 14 | 5.35e-01 | 9.00e-01 | 0.17500 | 1.67e-01 | -0.051300 | 2.78e-01 | 0.74000 |
| Class A/1 (Rhodopsin-like receptors) | 41 | 5.35e-01 | 9.00e-01 | 0.09930 | -9.20e-02 | -0.037300 | 3.09e-01 | 0.68000 |
| Signaling by Non-Receptor Tyrosine Kinases | 33 | 5.36e-01 | 9.00e-01 | 0.11500 | -7.57e-02 | 0.087000 | 4.52e-01 | 0.38800 |
| Signaling by PTK6 | 33 | 5.36e-01 | 9.00e-01 | 0.11500 | -7.57e-02 | 0.087000 | 4.52e-01 | 0.38800 |
| Protein methylation | 12 | 5.36e-01 | 9.00e-01 | 0.19000 | -1.60e-01 | 0.104000 | 3.38e-01 | 0.53500 |
| Nuclear import of Rev protein | 31 | 5.36e-01 | 9.00e-01 | 0.11300 | 9.21e-02 | 0.065600 | 3.75e-01 | 0.52800 |
| Cargo trafficking to the periciliary membrane | 40 | 5.37e-01 | 9.00e-01 | 0.10300 | 9.80e-02 | -0.033200 | 2.84e-01 | 0.71700 |
| EPH-ephrin mediated repulsion of cells | 26 | 5.39e-01 | 9.00e-01 | 0.12700 | -1.25e-01 | 0.025400 | 2.72e-01 | 0.82300 |
| Ion homeostasis | 26 | 5.39e-01 | 9.00e-01 | 0.12400 | -3.81e-02 | -0.118000 | 7.37e-01 | 0.29800 |
| Signaling by NTRKs | 90 | 5.39e-01 | 9.00e-01 | 0.06960 | -5.38e-02 | 0.044100 | 3.79e-01 | 0.47000 |
| TNFR1-induced proapoptotic signaling | 11 | 5.40e-01 | 9.00e-01 | 0.19000 | -7.61e-02 | -0.174000 | 6.62e-01 | 0.31900 |
| PKA activation | 10 | 5.41e-01 | 9.00e-01 | 0.20800 | -1.47e-01 | 0.147000 | 4.23e-01 | 0.42000 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 16 | 5.41e-01 | 9.00e-01 | 0.16100 | 2.61e-02 | -0.159000 | 8.56e-01 | 0.27100 |
| Processing of SMDT1 | 12 | 5.41e-01 | 9.00e-01 | 0.18000 | -1.43e-01 | -0.109000 | 3.90e-01 | 0.51300 |
| Fc epsilon receptor (FCERI) signaling | 109 | 5.41e-01 | 9.00e-01 | 0.06290 | -5.58e-02 | 0.029000 | 3.16e-01 | 0.60200 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | 33 | 5.42e-01 | 9.00e-01 | 0.11400 | 9.59e-02 | -0.061700 | 3.41e-01 | 0.54000 |
| Diseases of mitotic cell cycle | 33 | 5.42e-01 | 9.00e-01 | 0.11400 | 9.59e-02 | -0.061700 | 3.41e-01 | 0.54000 |
| ROS and RNS production in phagocytes | 23 | 5.43e-01 | 9.00e-01 | 0.13300 | -1.33e-01 | -0.002970 | 2.70e-01 | 0.98000 |
| Ca-dependent events | 21 | 5.44e-01 | 9.00e-01 | 0.14000 | -2.52e-02 | 0.138000 | 8.42e-01 | 0.27400 |
| Cell recruitment (pro-inflammatory response) | 14 | 5.44e-01 | 9.00e-01 | 0.17500 | 1.18e-01 | -0.129000 | 4.46e-01 | 0.40400 |
| Purinergic signaling in leishmaniasis infection | 14 | 5.44e-01 | 9.00e-01 | 0.17500 | 1.18e-01 | -0.129000 | 4.46e-01 | 0.40400 |
| Downstream signaling events of B Cell Receptor (BCR) | 70 | 5.44e-01 | 9.00e-01 | 0.07510 | -7.08e-02 | -0.025100 | 3.07e-01 | 0.71700 |
| CDT1 association with the CDC6:ORC:origin complex | 50 | 5.45e-01 | 9.00e-01 | 0.08860 | -3.44e-02 | -0.081600 | 6.75e-01 | 0.31900 |
| Meiotic synapsis | 23 | 5.45e-01 | 9.00e-01 | 0.13600 | 7.66e-02 | -0.112000 | 5.25e-01 | 0.35100 |
| Interleukin-12 family signaling | 41 | 5.45e-01 | 9.00e-01 | 0.09890 | 1.11e-02 | 0.098300 | 9.02e-01 | 0.27700 |
| RUNX2 regulates osteoblast differentiation | 12 | 5.45e-01 | 9.00e-01 | 0.18400 | 1.32e-02 | -0.184000 | 9.37e-01 | 0.27100 |
| Interleukin-6 signaling | 10 | 5.46e-01 | 9.00e-01 | 0.19600 | 1.15e-01 | 0.159000 | 5.29e-01 | 0.38500 |
| Signaling by Erythropoietin | 20 | 5.46e-01 | 9.00e-01 | 0.14500 | -7.71e-02 | 0.123000 | 5.51e-01 | 0.34000 |
| Peptide ligand-binding receptors | 16 | 5.48e-01 | 9.01e-01 | 0.15600 | -4.74e-02 | -0.149000 | 7.43e-01 | 0.30400 |
| G alpha (z) signalling events | 24 | 5.49e-01 | 9.01e-01 | 0.12800 | 2.55e-02 | 0.125000 | 8.29e-01 | 0.28800 |
| Vpr-mediated nuclear import of PICs | 32 | 5.51e-01 | 9.01e-01 | 0.10900 | 9.11e-02 | 0.059700 | 3.73e-01 | 0.55900 |
| IRS-mediated signalling | 21 | 5.52e-01 | 9.01e-01 | 0.13400 | -1.08e-01 | -0.079600 | 3.92e-01 | 0.52800 |
| Amyloid fiber formation | 24 | 5.52e-01 | 9.01e-01 | 0.12600 | -1.04e-01 | -0.070100 | 3.78e-01 | 0.55300 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 16 | 5.52e-01 | 9.01e-01 | 0.15400 | -1.24e-01 | -0.090100 | 3.89e-01 | 0.53300 |
| TICAM1, RIP1-mediated IKK complex recruitment | 17 | 5.53e-01 | 9.01e-01 | 0.15600 | 1.33e-01 | -0.080900 | 3.41e-01 | 0.56400 |
| SUMOylation of SUMOylation proteins | 32 | 5.53e-01 | 9.01e-01 | 0.10900 | 9.15e-02 | 0.058500 | 3.71e-01 | 0.56700 |
| Molecules associated with elastic fibres | 12 | 5.55e-01 | 9.01e-01 | 0.18300 | 5.11e-02 | -0.176000 | 7.59e-01 | 0.29100 |
| Cytochrome c-mediated apoptotic response | 10 | 5.56e-01 | 9.01e-01 | 0.20300 | 1.49e-01 | -0.137000 | 4.14e-01 | 0.45300 |
| Hedgehog 'on' state | 61 | 5.57e-01 | 9.01e-01 | 0.07830 | -5.04e-02 | -0.059900 | 4.97e-01 | 0.42000 |
| Signaling by NOTCH1 | 51 | 5.58e-01 | 9.01e-01 | 0.08730 | -8.73e-02 | -0.003080 | 2.82e-01 | 0.97000 |
| PLC beta mediated events | 30 | 5.58e-01 | 9.01e-01 | 0.11400 | -2.17e-03 | 0.114000 | 9.84e-01 | 0.28000 |
| G-protein mediated events | 31 | 5.59e-01 | 9.01e-01 | 0.11200 | -7.94e-03 | 0.112000 | 9.39e-01 | 0.28100 |
| Phosphorylation of the APC/C | 18 | 5.59e-01 | 9.01e-01 | 0.15000 | 6.05e-02 | -0.137000 | 6.57e-01 | 0.31500 |
| NRIF signals cell death from the nucleus | 14 | 5.61e-01 | 9.03e-01 | 0.16200 | -1.20e-01 | -0.108000 | 4.36e-01 | 0.48300 |
| Intraflagellar transport | 35 | 5.63e-01 | 9.03e-01 | 0.10600 | -2.69e-02 | 0.103000 | 7.83e-01 | 0.29400 |
| Carboxyterminal post-translational modifications of tubulin | 20 | 5.65e-01 | 9.03e-01 | 0.13500 | 7.78e-02 | 0.110000 | 5.47e-01 | 0.39500 |
| Signaling by Hedgehog | 97 | 5.65e-01 | 9.03e-01 | 0.06150 | -5.37e-02 | -0.030100 | 3.62e-01 | 0.61000 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 66 | 5.66e-01 | 9.03e-01 | 0.07470 | -2.99e-02 | -0.068400 | 6.75e-01 | 0.33700 |
| Regulation of innate immune responses to cytosolic DNA | 12 | 5.69e-01 | 9.03e-01 | 0.17400 | -5.92e-02 | -0.164000 | 7.22e-01 | 0.32600 |
| Phase I - Functionalization of compounds | 30 | 5.70e-01 | 9.03e-01 | 0.10900 | 8.65e-02 | 0.066500 | 4.13e-01 | 0.52900 |
| Opioid Signalling | 55 | 5.71e-01 | 9.03e-01 | 0.08070 | 4.18e-02 | 0.069100 | 5.93e-01 | 0.37600 |
| AKT phosphorylates targets in the cytosol | 13 | 5.71e-01 | 9.03e-01 | 0.17400 | -1.42e-01 | 0.100000 | 3.76e-01 | 0.53300 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 41 | 5.72e-01 | 9.03e-01 | 0.09320 | -5.39e-02 | -0.076000 | 5.51e-01 | 0.40000 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | 41 | 5.72e-01 | 9.03e-01 | 0.09320 | -5.39e-02 | -0.076000 | 5.51e-01 | 0.40000 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 41 | 5.72e-01 | 9.03e-01 | 0.09320 | -5.39e-02 | -0.076000 | 5.51e-01 | 0.40000 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | 41 | 5.72e-01 | 9.03e-01 | 0.09320 | -5.39e-02 | -0.076000 | 5.51e-01 | 0.40000 |
| Signaling by NOTCH1 in Cancer | 41 | 5.72e-01 | 9.03e-01 | 0.09320 | -5.39e-02 | -0.076000 | 5.51e-01 | 0.40000 |
| trans-Golgi Network Vesicle Budding | 52 | 5.72e-01 | 9.03e-01 | 0.08640 | -3.46e-02 | 0.079200 | 6.67e-01 | 0.32400 |
| Global Genome Nucleotide Excision Repair (GG-NER) | 76 | 5.73e-01 | 9.04e-01 | 0.07170 | -6.13e-02 | 0.037100 | 3.56e-01 | 0.57700 |
| MAP2K and MAPK activation | 25 | 5.75e-01 | 9.05e-01 | 0.11900 | -5.62e-02 | -0.105000 | 6.27e-01 | 0.36400 |
| CLEC7A (Dectin-1) signaling | 84 | 5.76e-01 | 9.05e-01 | 0.06660 | -6.65e-02 | 0.003050 | 2.93e-01 | 0.96200 |
| Insulin receptor signalling cascade | 26 | 5.78e-01 | 9.05e-01 | 0.11600 | -6.94e-02 | -0.092800 | 5.40e-01 | 0.41300 |
| Signaling by FGFR2 in disease | 23 | 5.80e-01 | 9.05e-01 | 0.12800 | -1.16e-01 | 0.054700 | 3.36e-01 | 0.65000 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 19 | 5.80e-01 | 9.05e-01 | 0.13800 | -1.38e-01 | 0.002240 | 2.97e-01 | 0.98700 |
| RUNX2 regulates bone development | 17 | 5.84e-01 | 9.05e-01 | 0.14900 | 8.42e-02 | -0.123000 | 5.48e-01 | 0.38200 |
| Signaling by KIT in disease | 17 | 5.85e-01 | 9.05e-01 | 0.14800 | 1.26e-01 | -0.078300 | 3.69e-01 | 0.57700 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 17 | 5.85e-01 | 9.05e-01 | 0.14800 | 1.26e-01 | -0.078300 | 3.69e-01 | 0.57700 |
| Signaling by NOTCH3 | 30 | 5.87e-01 | 9.05e-01 | 0.10600 | -6.88e-02 | -0.081000 | 5.15e-01 | 0.44300 |
| Glycosphingolipid metabolism | 27 | 5.87e-01 | 9.05e-01 | 0.11800 | -6.58e-02 | 0.097400 | 5.54e-01 | 0.38100 |
| Cellular response to heat stress | 79 | 5.87e-01 | 9.05e-01 | 0.06660 | -6.54e-02 | -0.012800 | 3.16e-01 | 0.84500 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 30 | 5.88e-01 | 9.05e-01 | 0.11100 | 6.44e-02 | -0.090900 | 5.42e-01 | 0.38900 |
| IGF1R signaling cascade | 23 | 5.89e-01 | 9.05e-01 | 0.12100 | -9.65e-02 | -0.072700 | 4.23e-01 | 0.54600 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 23 | 5.89e-01 | 9.05e-01 | 0.12100 | -9.65e-02 | -0.072700 | 4.23e-01 | 0.54600 |
| Hedgehog ligand biogenesis | 51 | 5.91e-01 | 9.05e-01 | 0.08280 | -8.28e-02 | -0.003200 | 3.07e-01 | 0.96800 |
| ADORA2B mediated anti-inflammatory cytokines production | 30 | 5.91e-01 | 9.05e-01 | 0.11000 | -4.24e-02 | 0.102000 | 6.88e-01 | 0.33600 |
| Signaling by VEGF | 73 | 5.92e-01 | 9.05e-01 | 0.07080 | -6.39e-02 | 0.030600 | 3.46e-01 | 0.65200 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 16 | 5.92e-01 | 9.05e-01 | 0.14700 | -2.22e-02 | -0.145000 | 8.78e-01 | 0.31600 |
| Diseases of programmed cell death | 21 | 5.93e-01 | 9.05e-01 | 0.12900 | 4.90e-03 | 0.128000 | 9.69e-01 | 0.30900 |
| FCGR3A-mediated phagocytosis | 43 | 5.93e-01 | 9.05e-01 | 0.09200 | -4.26e-02 | 0.081600 | 6.29e-01 | 0.35500 |
| Leishmania phagocytosis | 43 | 5.93e-01 | 9.05e-01 | 0.09200 | -4.26e-02 | 0.081600 | 6.29e-01 | 0.35500 |
| Parasite infection | 43 | 5.93e-01 | 9.05e-01 | 0.09200 | -4.26e-02 | 0.081600 | 6.29e-01 | 0.35500 |
| Infection with Mycobacterium tuberculosis | 22 | 5.93e-01 | 9.05e-01 | 0.12300 | -6.36e-02 | -0.105000 | 6.06e-01 | 0.39300 |
| Defects in vitamin and cofactor metabolism | 16 | 5.94e-01 | 9.05e-01 | 0.15100 | 1.30e-01 | -0.077200 | 3.70e-01 | 0.59300 |
| Integration of energy metabolism | 58 | 5.96e-01 | 9.08e-01 | 0.07910 | -6.73e-02 | 0.041600 | 3.77e-01 | 0.58500 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | 10 | 5.98e-01 | 9.09e-01 | 0.18400 | -1.83e-01 | -0.021900 | 3.17e-01 | 0.90500 |
| Transferrin endocytosis and recycling | 19 | 6.00e-01 | 9.12e-01 | 0.13300 | 1.49e-02 | 0.132000 | 9.10e-01 | 0.31900 |
| Metalloprotease DUBs | 16 | 6.02e-01 | 9.13e-01 | 0.14600 | 1.45e-01 | -0.016900 | 3.15e-01 | 0.90700 |
| Ephrin signaling | 12 | 6.04e-01 | 9.15e-01 | 0.16400 | -1.46e-01 | -0.074700 | 3.82e-01 | 0.65400 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 27 | 6.06e-01 | 9.15e-01 | 0.10900 | -9.45e-02 | -0.054200 | 3.96e-01 | 0.62600 |
| CD28 co-stimulation | 27 | 6.06e-01 | 9.15e-01 | 0.11300 | -1.07e-01 | 0.038000 | 3.38e-01 | 0.73300 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 46 | 6.07e-01 | 9.15e-01 | 0.08320 | -6.44e-02 | -0.052700 | 4.51e-01 | 0.53700 |
| PKA-mediated phosphorylation of CREB | 11 | 6.08e-01 | 9.15e-01 | 0.17700 | -7.88e-02 | 0.159000 | 6.51e-01 | 0.36200 |
| Diseases associated with the TLR signaling cascade | 15 | 6.09e-01 | 9.15e-01 | 0.15000 | 1.45e-01 | -0.037800 | 3.30e-01 | 0.80000 |
| Diseases of Immune System | 15 | 6.09e-01 | 9.15e-01 | 0.15000 | 1.45e-01 | -0.037800 | 3.30e-01 | 0.80000 |
| Transcriptional Regulation by MECP2 | 31 | 6.13e-01 | 9.17e-01 | 0.10300 | 1.22e-02 | -0.103000 | 9.07e-01 | 0.32400 |
| Rho GTPase cycle | 81 | 6.19e-01 | 9.17e-01 | 0.06170 | 5.31e-02 | 0.031400 | 4.10e-01 | 0.62600 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 64 | 6.19e-01 | 9.17e-01 | 0.06920 | -5.68e-02 | -0.039500 | 4.33e-01 | 0.58500 |
| Activation of the pre-replicative complex | 28 | 6.19e-01 | 9.17e-01 | 0.10500 | 9.14e-02 | 0.050800 | 4.03e-01 | 0.64200 |
| Metabolism of nitric oxide: NOS3 activation and regulation | 11 | 6.20e-01 | 9.17e-01 | 0.17400 | -9.62e-02 | 0.145000 | 5.81e-01 | 0.40400 |
| Costimulation by the CD28 family | 45 | 6.20e-01 | 9.17e-01 | 0.08240 | -7.01e-02 | -0.043400 | 4.17e-01 | 0.61500 |
| G-protein activation | 13 | 6.23e-01 | 9.17e-01 | 0.15700 | 1.56e-01 | -0.016700 | 3.31e-01 | 0.91700 |
| Activation of G protein gated Potassium channels | 11 | 6.23e-01 | 9.17e-01 | 0.16800 | 1.66e-01 | 0.027500 | 3.42e-01 | 0.87500 |
| G protein gated Potassium channels | 11 | 6.23e-01 | 9.17e-01 | 0.16800 | 1.66e-01 | 0.027500 | 3.42e-01 | 0.87500 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 11 | 6.23e-01 | 9.17e-01 | 0.16800 | 1.66e-01 | 0.027500 | 3.42e-01 | 0.87500 |
| AMER1 mutants destabilize the destruction complex | 12 | 6.23e-01 | 9.17e-01 | 0.15900 | 1.42e-01 | 0.071300 | 3.95e-01 | 0.66900 |
| APC truncation mutants have impaired AXIN binding | 12 | 6.23e-01 | 9.17e-01 | 0.15900 | 1.42e-01 | 0.071300 | 3.95e-01 | 0.66900 |
| AXIN missense mutants destabilize the destruction complex | 12 | 6.23e-01 | 9.17e-01 | 0.15900 | 1.42e-01 | 0.071300 | 3.95e-01 | 0.66900 |
| AXIN mutants destabilize the destruction complex, activating WNT signaling | 12 | 6.23e-01 | 9.17e-01 | 0.15900 | 1.42e-01 | 0.071300 | 3.95e-01 | 0.66900 |
| Truncations of AMER1 destabilize the destruction complex | 12 | 6.23e-01 | 9.17e-01 | 0.15900 | 1.42e-01 | 0.071300 | 3.95e-01 | 0.66900 |
| truncated APC mutants destabilize the destruction complex | 12 | 6.23e-01 | 9.17e-01 | 0.15900 | 1.42e-01 | 0.071300 | 3.95e-01 | 0.66900 |
| Triglyceride catabolism | 11 | 6.26e-01 | 9.18e-01 | 0.16500 | 1.42e-01 | 0.084100 | 4.16e-01 | 0.62900 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 66 | 6.26e-01 | 9.18e-01 | 0.06730 | -4.74e-02 | -0.047700 | 5.06e-01 | 0.50400 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 12 | 6.26e-01 | 9.18e-01 | 0.16100 | 1.61e-01 | 0.004980 | 3.35e-01 | 0.97600 |
| FCERI mediated MAPK activation | 25 | 6.28e-01 | 9.18e-01 | 0.11300 | -2.53e-02 | 0.110000 | 8.27e-01 | 0.34200 |
| Signalling to RAS | 13 | 6.28e-01 | 9.18e-01 | 0.15800 | 1.30e-01 | -0.090800 | 4.19e-01 | 0.57100 |
| Mitochondrial biogenesis | 50 | 6.31e-01 | 9.20e-01 | 0.07810 | 8.29e-03 | 0.077600 | 9.19e-01 | 0.34300 |
| Golgi Associated Vesicle Biogenesis | 39 | 6.31e-01 | 9.20e-01 | 0.09050 | -3.88e-02 | 0.081800 | 6.76e-01 | 0.37700 |
| Regulation of ornithine decarboxylase (ODC) | 43 | 6.32e-01 | 9.20e-01 | 0.08430 | -8.43e-02 | -0.002330 | 3.40e-01 | 0.97900 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 34 | 6.33e-01 | 9.21e-01 | 0.09550 | -1.47e-02 | 0.094400 | 8.83e-01 | 0.34200 |
| Regulation of actin dynamics for phagocytic cup formation | 45 | 6.35e-01 | 9.22e-01 | 0.08400 | -4.15e-02 | 0.073100 | 6.31e-01 | 0.39700 |
| Inwardly rectifying K+ channels | 12 | 6.39e-01 | 9.25e-01 | 0.16000 | 1.52e-01 | -0.050300 | 3.62e-01 | 0.76300 |
| Hemostasis | 304 | 6.39e-01 | 9.25e-01 | 0.03210 | -3.16e-02 | 0.005990 | 3.48e-01 | 0.85900 |
| Bile acid and bile salt metabolism | 14 | 6.40e-01 | 9.25e-01 | 0.14900 | 1.25e-01 | -0.081100 | 4.18e-01 | 0.60000 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 13 | 6.40e-01 | 9.25e-01 | 0.15000 | -3.22e-02 | -0.146000 | 8.41e-01 | 0.36200 |
| Formation of tubulin folding intermediates by CCT/TriC | 14 | 6.42e-01 | 9.26e-01 | 0.14700 | -1.43e-01 | 0.034300 | 3.55e-01 | 0.82400 |
| Collagen degradation | 14 | 6.43e-01 | 9.26e-01 | 0.14500 | 9.01e-03 | 0.144000 | 9.53e-01 | 0.35000 |
| Innate Immune System | 617 | 6.44e-01 | 9.27e-01 | 0.02220 | -2.09e-02 | -0.007330 | 3.84e-01 | 0.76000 |
| NR1H2 and NR1H3-mediated signaling | 26 | 6.45e-01 | 9.27e-01 | 0.10400 | -9.47e-02 | -0.043100 | 4.04e-01 | 0.70400 |
| Myogenesis | 13 | 6.46e-01 | 9.27e-01 | 0.15300 | 7.60e-02 | -0.133000 | 6.35e-01 | 0.40700 |
| COPI-mediated anterograde transport | 68 | 6.46e-01 | 9.27e-01 | 0.06670 | 6.26e-02 | -0.023100 | 3.73e-01 | 0.74200 |
| Interleukin-1 family signaling | 97 | 6.47e-01 | 9.27e-01 | 0.05430 | -1.27e-02 | -0.052800 | 8.29e-01 | 0.37100 |
| Signaling by Leptin | 10 | 6.50e-01 | 9.30e-01 | 0.17300 | -1.49e-01 | 0.088800 | 4.16e-01 | 0.62700 |
| Signaling by ERBB4 | 31 | 6.54e-01 | 9.34e-01 | 0.09550 | -1.38e-03 | -0.095500 | 9.89e-01 | 0.35800 |
| Mismatch Repair | 13 | 6.55e-01 | 9.34e-01 | 0.14400 | -1.21e-01 | -0.077100 | 4.48e-01 | 0.63000 |
| Glutathione conjugation | 20 | 6.56e-01 | 9.34e-01 | 0.12000 | 1.16e-01 | -0.030400 | 3.69e-01 | 0.81400 |
| GABA receptor activation | 18 | 6.57e-01 | 9.35e-01 | 0.12200 | 9.09e-02 | 0.080900 | 5.05e-01 | 0.55300 |
| Activation of kainate receptors upon glutamate binding | 16 | 6.60e-01 | 9.37e-01 | 0.13000 | 2.89e-02 | 0.127000 | 8.41e-01 | 0.38000 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | 25 | 6.62e-01 | 9.40e-01 | 0.10600 | -3.14e-02 | 0.102000 | 7.86e-01 | 0.37900 |
| G alpha (s) signalling events | 44 | 6.65e-01 | 9.43e-01 | 0.07850 | 3.52e-03 | 0.078400 | 9.68e-01 | 0.36900 |
| Rev-mediated nuclear export of HIV RNA | 33 | 6.66e-01 | 9.43e-01 | 0.08850 | 6.03e-02 | 0.064800 | 5.49e-01 | 0.52000 |
| Glutamate Neurotransmitter Release Cycle | 11 | 6.68e-01 | 9.44e-01 | 0.15400 | -5.09e-02 | -0.145000 | 7.70e-01 | 0.40400 |
| p75 NTR receptor-mediated signalling | 60 | 6.68e-01 | 9.44e-01 | 0.06870 | -3.83e-02 | 0.057000 | 6.08e-01 | 0.44600 |
| VEGFA-VEGFR2 Pathway | 71 | 6.74e-01 | 9.44e-01 | 0.06250 | -5.04e-02 | 0.037100 | 4.64e-01 | 0.59000 |
| G beta:gamma signalling through BTK | 10 | 6.75e-01 | 9.44e-01 | 0.15800 | 1.23e-01 | 0.099200 | 5.01e-01 | 0.58700 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | 12 | 6.77e-01 | 9.44e-01 | 0.14400 | -1.23e-01 | -0.075700 | 4.63e-01 | 0.65000 |
| Cyclin E associated events during G1/S transition | 72 | 6.78e-01 | 9.44e-01 | 0.05900 | -2.38e-02 | -0.054000 | 7.28e-01 | 0.42900 |
| Cyclin A:Cdk2-associated events at S phase entry | 74 | 6.79e-01 | 9.44e-01 | 0.05790 | -3.04e-02 | -0.049300 | 6.52e-01 | 0.46400 |
| Interleukin-6 family signaling | 12 | 6.80e-01 | 9.44e-01 | 0.14600 | -6.09e-04 | 0.146000 | 9.97e-01 | 0.38000 |
| Adaptive Immune System | 474 | 6.80e-01 | 9.44e-01 | 0.02400 | 2.39e-02 | -0.001890 | 3.80e-01 | 0.94500 |
| Recognition of DNA damage by PCNA-containing replication complex | 26 | 6.81e-01 | 9.44e-01 | 0.10000 | -9.80e-02 | 0.021500 | 3.87e-01 | 0.84900 |
| Signaling by NTRK1 (TRKA) | 82 | 6.82e-01 | 9.44e-01 | 0.05740 | -4.65e-02 | 0.033700 | 4.68e-01 | 0.59900 |
| Regulation of RUNX2 expression and activity | 57 | 6.82e-01 | 9.44e-01 | 0.06720 | 3.48e-03 | -0.067100 | 9.64e-01 | 0.38100 |
| Transmission across Chemical Synapses | 96 | 6.82e-01 | 9.44e-01 | 0.05310 | -3.55e-02 | 0.039500 | 5.49e-01 | 0.50500 |
| Gene Silencing by RNA | 58 | 6.82e-01 | 9.44e-01 | 0.06500 | 3.40e-02 | 0.055400 | 6.55e-01 | 0.46700 |
| PPARA activates gene expression | 79 | 6.82e-01 | 9.44e-01 | 0.05560 | 3.86e-02 | 0.040000 | 5.54e-01 | 0.54000 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 38 | 6.83e-01 | 9.44e-01 | 0.08090 | -7.83e-02 | -0.020300 | 4.04e-01 | 0.82900 |
| Assembly of the pre-replicative complex | 59 | 6.84e-01 | 9.44e-01 | 0.06420 | -3.30e-02 | -0.055100 | 6.62e-01 | 0.46500 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | 30 | 6.84e-01 | 9.44e-01 | 0.09340 | -3.14e-02 | 0.088000 | 7.66e-01 | 0.40500 |
| MAPK family signaling cascades | 186 | 6.86e-01 | 9.44e-01 | 0.03810 | -2.27e-02 | 0.030600 | 5.96e-01 | 0.47500 |
| Toll-like Receptor Cascades | 107 | 6.88e-01 | 9.44e-01 | 0.04740 | 3.48e-02 | 0.032200 | 5.36e-01 | 0.56700 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 52 | 6.89e-01 | 9.44e-01 | 0.06760 | -4.06e-02 | -0.054100 | 6.13e-01 | 0.50100 |
| Late Phase of HIV Life Cycle | 115 | 6.89e-01 | 9.44e-01 | 0.04780 | -4.11e-02 | 0.024300 | 4.48e-01 | 0.65300 |
| Termination of translesion DNA synthesis | 28 | 6.89e-01 | 9.44e-01 | 0.09210 | 4.64e-02 | 0.079600 | 6.71e-01 | 0.46600 |
| Transcriptional regulation of white adipocyte differentiation | 55 | 6.90e-01 | 9.44e-01 | 0.06620 | 2.17e-02 | 0.062500 | 7.82e-01 | 0.42300 |
| Neurotransmitter receptors and postsynaptic signal transmission | 74 | 6.91e-01 | 9.44e-01 | 0.05930 | -3.32e-02 | 0.049200 | 6.22e-01 | 0.46600 |
| Removal of the Flap Intermediate | 12 | 6.91e-01 | 9.44e-01 | 0.14000 | -6.60e-02 | -0.124000 | 6.92e-01 | 0.45800 |
| IRE1alpha activates chaperones | 37 | 6.92e-01 | 9.44e-01 | 0.08320 | -7.39e-02 | 0.038200 | 4.37e-01 | 0.68800 |
| RORA activates gene expression | 10 | 6.93e-01 | 9.44e-01 | 0.15300 | 6.99e-02 | 0.136000 | 7.02e-01 | 0.45600 |
| Diseases of glycosylation | 68 | 6.93e-01 | 9.44e-01 | 0.06170 | -4.23e-02 | 0.044800 | 5.47e-01 | 0.52300 |
| Antigen processing-Cross presentation | 76 | 6.95e-01 | 9.44e-01 | 0.05560 | -2.28e-02 | -0.050800 | 7.32e-01 | 0.44500 |
| S Phase | 138 | 6.96e-01 | 9.44e-01 | 0.04300 | 1.92e-02 | -0.038500 | 6.98e-01 | 0.43700 |
| TRAF6 mediated NF-kB activation | 18 | 6.97e-01 | 9.44e-01 | 0.11300 | 8.08e-02 | 0.078700 | 5.53e-01 | 0.56300 |
| Regulation of Apoptosis | 45 | 6.98e-01 | 9.44e-01 | 0.07160 | -6.29e-02 | -0.034200 | 4.66e-01 | 0.69200 |
| Other interleukin signaling | 15 | 6.98e-01 | 9.44e-01 | 0.12900 | -1.14e-01 | 0.059800 | 4.43e-01 | 0.68900 |
| Biological oxidations | 78 | 6.98e-01 | 9.44e-01 | 0.05420 | 3.80e-02 | 0.038600 | 5.63e-01 | 0.55600 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | 18 | 6.99e-01 | 9.44e-01 | 0.11700 | 4.92e-02 | -0.107000 | 7.18e-01 | 0.43400 |
| Class B/2 (Secretin family receptors) | 26 | 6.99e-01 | 9.44e-01 | 0.09680 | -1.93e-02 | 0.094900 | 8.65e-01 | 0.40300 |
| Antigen processing: Ubiquitination & Proteasome degradation | 236 | 7.00e-01 | 9.44e-01 | 0.03200 | 3.20e-02 | 0.001890 | 4.01e-01 | 0.96100 |
| Rap1 signalling | 10 | 7.00e-01 | 9.44e-01 | 0.15000 | 1.08e-01 | 0.104000 | 5.53e-01 | 0.56800 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 62 | 7.01e-01 | 9.45e-01 | 0.06310 | 5.81e-02 | -0.024600 | 4.30e-01 | 0.73900 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 56 | 7.05e-01 | 9.50e-01 | 0.06310 | -3.48e-02 | -0.052700 | 6.53e-01 | 0.49600 |
| PKMTs methylate histone lysines | 30 | 7.08e-01 | 9.52e-01 | 0.08960 | 4.43e-02 | -0.077900 | 6.75e-01 | 0.46100 |
| Cell death signalling via NRAGE, NRIF and NADE | 46 | 7.09e-01 | 9.52e-01 | 0.07160 | -1.88e-02 | 0.069100 | 8.26e-01 | 0.41800 |
| PERK regulates gene expression | 26 | 7.10e-01 | 9.52e-01 | 0.09310 | 9.24e-02 | 0.011700 | 4.15e-01 | 0.91800 |
| Transcriptional activation of mitochondrial biogenesis | 36 | 7.11e-01 | 9.52e-01 | 0.07880 | 1.36e-02 | 0.077600 | 8.88e-01 | 0.42100 |
| Sema3A PAK dependent Axon repulsion | 11 | 7.12e-01 | 9.52e-01 | 0.14300 | -6.07e-03 | -0.143000 | 9.72e-01 | 0.41100 |
| Signaling by FGFR | 51 | 7.12e-01 | 9.52e-01 | 0.06850 | -4.91e-02 | 0.047800 | 5.45e-01 | 0.55600 |
| Postmitotic nuclear pore complex (NPC) reformation | 26 | 7.14e-01 | 9.53e-01 | 0.09100 | 7.88e-02 | 0.045400 | 4.87e-01 | 0.68900 |
| ER to Golgi Anterograde Transport | 105 | 7.15e-01 | 9.53e-01 | 0.04620 | 4.61e-02 | 0.003320 | 4.16e-01 | 0.95300 |
| MAP kinase activation | 50 | 7.18e-01 | 9.56e-01 | 0.06560 | -1.93e-02 | -0.062700 | 8.14e-01 | 0.44400 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 13 | 7.20e-01 | 9.56e-01 | 0.13300 | -1.03e-01 | 0.084600 | 5.21e-01 | 0.59800 |
| E3 ubiquitin ligases ubiquitinate target proteins | 41 | 7.21e-01 | 9.56e-01 | 0.07330 | -7.30e-02 | 0.006220 | 4.19e-01 | 0.94500 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 26 | 7.22e-01 | 9.56e-01 | 0.09150 | 5.79e-05 | 0.091500 | 1.00e+00 | 0.42000 |
| Insulin receptor recycling | 17 | 7.22e-01 | 9.56e-01 | 0.11300 | -7.69e-03 | 0.113000 | 9.56e-01 | 0.42000 |
| BBSome-mediated cargo-targeting to cilium | 19 | 7.23e-01 | 9.56e-01 | 0.10800 | 2.11e-02 | -0.106000 | 8.74e-01 | 0.42600 |
| Transcriptional regulation by RUNX2 | 83 | 7.26e-01 | 9.56e-01 | 0.05130 | 7.05e-03 | -0.050800 | 9.12e-01 | 0.42500 |
| SLC-mediated transmembrane transport | 97 | 7.27e-01 | 9.56e-01 | 0.04610 | -1.93e-02 | -0.041800 | 7.43e-01 | 0.47800 |
| Signaling by ERBB2 | 32 | 7.28e-01 | 9.56e-01 | 0.08210 | -1.67e-02 | 0.080400 | 8.70e-01 | 0.43200 |
| Post NMDA receptor activation events | 38 | 7.29e-01 | 9.56e-01 | 0.07390 | -1.29e-02 | -0.072800 | 8.91e-01 | 0.43800 |
| mRNA decay by 5' to 3' exoribonuclease | 15 | 7.29e-01 | 9.56e-01 | 0.12000 | -1.16e-01 | 0.030200 | 4.37e-01 | 0.84000 |
| Glucose metabolism | 72 | 7.31e-01 | 9.56e-01 | 0.05540 | -4.45e-02 | 0.033000 | 5.15e-01 | 0.62900 |
| APC/C-mediated degradation of cell cycle proteins | 77 | 7.31e-01 | 9.56e-01 | 0.05250 | 6.27e-03 | -0.052100 | 9.24e-01 | 0.43000 |
| Regulation of mitotic cell cycle | 77 | 7.31e-01 | 9.56e-01 | 0.05250 | 6.27e-03 | -0.052100 | 9.24e-01 | 0.43000 |
| G beta:gamma signalling through PLC beta | 12 | 7.32e-01 | 9.56e-01 | 0.13000 | 3.96e-02 | 0.124000 | 8.12e-01 | 0.45900 |
| Presynaptic function of Kainate receptors | 12 | 7.32e-01 | 9.56e-01 | 0.13000 | 3.96e-02 | 0.124000 | 8.12e-01 | 0.45900 |
| Diseases associated with N-glycosylation of proteins | 15 | 7.32e-01 | 9.56e-01 | 0.11900 | 2.33e-02 | -0.117000 | 8.76e-01 | 0.43400 |
| G0 and Early G1 | 24 | 7.36e-01 | 9.56e-01 | 0.09000 | 6.56e-02 | 0.061500 | 5.78e-01 | 0.60200 |
| Regulation of PTEN stability and activity | 56 | 7.38e-01 | 9.56e-01 | 0.06110 | -5.82e-02 | 0.018700 | 4.52e-01 | 0.80900 |
| Interleukin-17 signaling | 53 | 7.39e-01 | 9.56e-01 | 0.06060 | -2.66e-02 | -0.054400 | 7.38e-01 | 0.49400 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 24 | 7.42e-01 | 9.56e-01 | 0.09300 | -4.25e-02 | 0.082800 | 7.19e-01 | 0.48300 |
| GPCR ligand binding | 68 | 7.42e-01 | 9.56e-01 | 0.05440 | -5.43e-02 | 0.003670 | 4.40e-01 | 0.95800 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 22 | 7.42e-01 | 9.56e-01 | 0.09270 | -5.90e-02 | -0.071500 | 6.32e-01 | 0.56200 |
| Nucleobase catabolism | 22 | 7.46e-01 | 9.56e-01 | 0.09270 | 8.79e-02 | 0.029600 | 4.76e-01 | 0.81000 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 17 | 7.47e-01 | 9.56e-01 | 0.10900 | 9.74e-02 | -0.049500 | 4.87e-01 | 0.72400 |
| Cargo concentration in the ER | 20 | 7.47e-01 | 9.56e-01 | 0.09690 | 8.93e-02 | 0.037500 | 4.90e-01 | 0.77100 |
| Protein ubiquitination | 59 | 7.49e-01 | 9.56e-01 | 0.05680 | -5.62e-02 | -0.008220 | 4.56e-01 | 0.91300 |
| Signaling by NOTCH | 130 | 7.50e-01 | 9.56e-01 | 0.03910 | -3.78e-02 | 0.010200 | 4.59e-01 | 0.84100 |
| ADP signalling through P2Y purinoceptor 12 | 12 | 7.53e-01 | 9.56e-01 | 0.12300 | 1.09e-01 | 0.056700 | 5.13e-01 | 0.73400 |
| Diseases associated with O-glycosylation of proteins | 21 | 7.53e-01 | 9.56e-01 | 0.09390 | -1.88e-02 | -0.092000 | 8.82e-01 | 0.46600 |
| RAB GEFs exchange GTP for GDP on RABs | 61 | 7.54e-01 | 9.56e-01 | 0.05710 | 4.51e-02 | -0.035000 | 5.43e-01 | 0.63700 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 33 | 7.55e-01 | 9.56e-01 | 0.07640 | 7.38e-02 | -0.019900 | 4.64e-01 | 0.84300 |
| Neurotransmitter release cycle | 19 | 7.57e-01 | 9.56e-01 | 0.10100 | -3.93e-02 | 0.092800 | 7.67e-01 | 0.48400 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 11 | 7.57e-01 | 9.56e-01 | 0.13200 | -1.24e-01 | 0.046400 | 4.78e-01 | 0.79000 |
| Activation of HOX genes during differentiation | 38 | 7.59e-01 | 9.56e-01 | 0.07120 | -3.37e-02 | 0.062700 | 7.20e-01 | 0.50400 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 38 | 7.59e-01 | 9.56e-01 | 0.07120 | -3.37e-02 | 0.062700 | 7.20e-01 | 0.50400 |
| IKK complex recruitment mediated by RIP1 | 17 | 7.59e-01 | 9.56e-01 | 0.10700 | 8.57e-02 | -0.063500 | 5.41e-01 | 0.65100 |
| Glycolysis | 57 | 7.59e-01 | 9.56e-01 | 0.05790 | -2.19e-02 | 0.053600 | 7.75e-01 | 0.48500 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 12 | 7.60e-01 | 9.56e-01 | 0.12100 | -1.09e-01 | -0.052400 | 5.13e-01 | 0.75300 |
| Activation of BH3-only proteins | 27 | 7.60e-01 | 9.56e-01 | 0.08030 | -4.97e-02 | -0.063100 | 6.55e-01 | 0.57100 |
| Nuclear Envelope (NE) Reassembly | 60 | 7.62e-01 | 9.56e-01 | 0.05580 | 5.40e-02 | -0.013900 | 4.70e-01 | 0.85200 |
| Potential therapeutics for SARS | 26 | 7.63e-01 | 9.56e-01 | 0.08190 | -7.71e-02 | -0.027700 | 4.97e-01 | 0.80700 |
| Activation of GABAB receptors | 17 | 7.64e-01 | 9.56e-01 | 0.10000 | 6.70e-02 | 0.074500 | 6.33e-01 | 0.59500 |
| GABA B receptor activation | 17 | 7.64e-01 | 9.56e-01 | 0.10000 | 6.70e-02 | 0.074500 | 6.33e-01 | 0.59500 |
| Growth hormone receptor signaling | 17 | 7.64e-01 | 9.56e-01 | 0.10300 | 1.02e-01 | -0.016500 | 4.66e-01 | 0.90600 |
| GPVI-mediated activation cascade | 24 | 7.65e-01 | 9.56e-01 | 0.08860 | -6.15e-02 | 0.063700 | 6.02e-01 | 0.58900 |
| ATF4 activates genes in response to endoplasmic reticulum stress | 23 | 7.68e-01 | 9.56e-01 | 0.08850 | 8.60e-02 | -0.021000 | 4.76e-01 | 0.86200 |
| Transport of small molecules | 342 | 7.68e-01 | 9.56e-01 | 0.02250 | -1.70e-02 | -0.014700 | 5.93e-01 | 0.64300 |
| MyD88 dependent cascade initiated on endosome | 67 | 7.69e-01 | 9.56e-01 | 0.05000 | -3.26e-02 | -0.037900 | 6.45e-01 | 0.59300 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 67 | 7.69e-01 | 9.56e-01 | 0.05000 | -3.26e-02 | -0.037900 | 6.45e-01 | 0.59300 |
| Diseases of signal transduction by growth factor receptors and second messengers | 260 | 7.70e-01 | 9.56e-01 | 0.02610 | 3.34e-03 | 0.025900 | 9.27e-01 | 0.47600 |
| DARPP-32 events | 20 | 7.71e-01 | 9.56e-01 | 0.09550 | 6.59e-02 | -0.069100 | 6.10e-01 | 0.59300 |
| Prolonged ERK activation events | 13 | 7.72e-01 | 9.56e-01 | 0.11700 | 1.12e-01 | -0.030700 | 4.83e-01 | 0.84800 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 22 | 7.73e-01 | 9.56e-01 | 0.09020 | -8.17e-02 | 0.038300 | 5.08e-01 | 0.75600 |
| Signaling by Insulin receptor | 42 | 7.74e-01 | 9.56e-01 | 0.06290 | -5.91e-02 | -0.021500 | 5.08e-01 | 0.81000 |
| RIP-mediated NFkB activation via ZBP1 | 14 | 7.74e-01 | 9.56e-01 | 0.11200 | 3.10e-02 | -0.108000 | 8.41e-01 | 0.48600 |
| Ovarian tumor domain proteases | 28 | 7.75e-01 | 9.56e-01 | 0.07720 | 7.56e-02 | 0.015800 | 4.89e-01 | 0.88500 |
| NOTCH4 Intracellular Domain Regulates Transcription | 14 | 7.76e-01 | 9.56e-01 | 0.10700 | -8.01e-02 | -0.071200 | 6.04e-01 | 0.64500 |
| Signal amplification | 19 | 7.76e-01 | 9.56e-01 | 0.09260 | 8.51e-02 | 0.036500 | 5.21e-01 | 0.78300 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 21 | 7.77e-01 | 9.56e-01 | 0.09160 | 7.68e-02 | -0.049900 | 5.43e-01 | 0.69200 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 29 | 7.77e-01 | 9.56e-01 | 0.07590 | -4.30e-03 | -0.075800 | 9.68e-01 | 0.48000 |
| Signaling by RAS mutants | 29 | 7.77e-01 | 9.56e-01 | 0.07590 | -4.30e-03 | -0.075800 | 9.68e-01 | 0.48000 |
| Signaling by moderate kinase activity BRAF mutants | 29 | 7.77e-01 | 9.56e-01 | 0.07590 | -4.30e-03 | -0.075800 | 9.68e-01 | 0.48000 |
| Signaling downstream of RAS mutants | 29 | 7.77e-01 | 9.56e-01 | 0.07590 | -4.30e-03 | -0.075800 | 9.68e-01 | 0.48000 |
| Regulation of MECP2 expression and activity | 23 | 7.78e-01 | 9.56e-01 | 0.08660 | 2.61e-02 | -0.082600 | 8.29e-01 | 0.49300 |
| tRNA processing in the nucleus | 55 | 7.79e-01 | 9.56e-01 | 0.05490 | 5.47e-02 | 0.004440 | 4.83e-01 | 0.95500 |
| RHO GTPases Activate WASPs and WAVEs | 29 | 7.79e-01 | 9.56e-01 | 0.07550 | 5.60e-03 | 0.075300 | 9.58e-01 | 0.48300 |
| Intra-Golgi traffic | 39 | 7.80e-01 | 9.56e-01 | 0.06400 | 5.67e-02 | 0.029700 | 5.41e-01 | 0.74900 |
| Negative regulation of MAPK pathway | 36 | 7.80e-01 | 9.56e-01 | 0.06670 | -2.48e-02 | -0.061900 | 7.97e-01 | 0.52100 |
| COPI-independent Golgi-to-ER retrograde traffic | 28 | 7.80e-01 | 9.56e-01 | 0.07840 | 7.24e-02 | -0.030000 | 5.08e-01 | 0.78400 |
| Cytosolic sensors of pathogen-associated DNA | 51 | 7.81e-01 | 9.56e-01 | 0.05840 | -4.15e-02 | 0.041200 | 6.09e-01 | 0.61200 |
| mRNA Capping | 25 | 7.82e-01 | 9.56e-01 | 0.08310 | -6.42e-02 | 0.052700 | 5.79e-01 | 0.64800 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 10 | 7.82e-01 | 9.56e-01 | 0.12700 | -1.66e-02 | -0.126000 | 9.27e-01 | 0.49000 |
| tRNA modification in the nucleus and cytosol | 34 | 7.82e-01 | 9.56e-01 | 0.06770 | -4.76e-02 | -0.048200 | 6.32e-01 | 0.62700 |
| Regulation of RAS by GAPs | 56 | 7.83e-01 | 9.56e-01 | 0.05430 | -5.42e-02 | 0.004190 | 4.84e-01 | 0.95700 |
| mRNA decay by 3' to 5' exoribonuclease | 14 | 7.83e-01 | 9.56e-01 | 0.10500 | -7.11e-02 | -0.077700 | 6.45e-01 | 0.61500 |
| Dual Incision in GG-NER | 35 | 7.83e-01 | 9.56e-01 | 0.06710 | -6.27e-02 | -0.023900 | 5.21e-01 | 0.80700 |
| Signaling by Interleukins | 262 | 7.85e-01 | 9.56e-01 | 0.02490 | -2.44e-02 | -0.004970 | 5.00e-01 | 0.89100 |
| KSRP (KHSRP) binds and destabilizes mRNA | 15 | 7.85e-01 | 9.56e-01 | 0.10200 | -4.00e-02 | -0.093500 | 7.88e-01 | 0.53100 |
| Non-integrin membrane-ECM interactions | 14 | 7.87e-01 | 9.56e-01 | 0.10800 | -1.06e-01 | 0.017500 | 4.92e-01 | 0.91000 |
| Transcriptional Regulation by VENTX | 30 | 7.87e-01 | 9.56e-01 | 0.07460 | 6.45e-02 | -0.037400 | 5.41e-01 | 0.72300 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 14 | 7.88e-01 | 9.56e-01 | 0.10900 | -6.12e-02 | 0.090300 | 6.92e-01 | 0.55900 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | 14 | 7.88e-01 | 9.56e-01 | 0.10900 | -6.12e-02 | 0.090300 | 6.92e-01 | 0.55900 |
| Interleukin-37 signaling | 17 | 7.90e-01 | 9.58e-01 | 0.09750 | 9.34e-02 | -0.028100 | 5.05e-01 | 0.84100 |
| Mitochondrial iron-sulfur cluster biogenesis | 10 | 7.92e-01 | 9.59e-01 | 0.12600 | 1.98e-02 | -0.124000 | 9.14e-01 | 0.49700 |
| Transcription of E2F targets under negative control by DREAM complex | 18 | 7.92e-01 | 9.59e-01 | 0.09300 | 3.32e-03 | -0.092900 | 9.81e-01 | 0.49500 |
| Activation of NMDA receptors and postsynaptic events | 43 | 7.93e-01 | 9.59e-01 | 0.05910 | -5.55e-02 | -0.020300 | 5.30e-01 | 0.81800 |
| Signaling by FGFR4 | 25 | 7.94e-01 | 9.59e-01 | 0.07660 | -6.12e-02 | -0.046100 | 5.97e-01 | 0.69000 |
| SCF(Skp2)-mediated degradation of p27/p21 | 52 | 7.96e-01 | 9.59e-01 | 0.05290 | -4.20e-02 | -0.032100 | 6.01e-01 | 0.68900 |
| Vitamin B5 (pantothenate) metabolism | 11 | 7.96e-01 | 9.59e-01 | 0.11900 | 1.15e-01 | -0.028900 | 5.08e-01 | 0.86800 |
| Visual phototransduction | 31 | 7.97e-01 | 9.59e-01 | 0.06840 | 3.42e-02 | 0.059200 | 7.42e-01 | 0.56900 |
| Intrinsic Pathway for Apoptosis | 45 | 7.99e-01 | 9.59e-01 | 0.05860 | 1.79e-02 | -0.055800 | 8.35e-01 | 0.51800 |
| Effects of PIP2 hydrolysis | 19 | 7.99e-01 | 9.59e-01 | 0.08980 | -2.36e-02 | 0.086700 | 8.59e-01 | 0.51300 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 10 | 8.00e-01 | 9.59e-01 | 0.12000 | 1.13e-01 | 0.041300 | 5.37e-01 | 0.82100 |
| ERKs are inactivated | 12 | 8.02e-01 | 9.61e-01 | 0.11300 | -9.42e-02 | 0.062900 | 5.72e-01 | 0.70600 |
| C-type lectin receptors (CLRs) | 100 | 8.05e-01 | 9.63e-01 | 0.03840 | -3.82e-02 | 0.003930 | 5.10e-01 | 0.94600 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 11 | 8.06e-01 | 9.63e-01 | 0.11700 | -5.55e-02 | 0.103000 | 7.50e-01 | 0.55500 |
| Regulation of lipid metabolism by PPARalpha | 81 | 8.07e-01 | 9.63e-01 | 0.04120 | 3.48e-02 | 0.022100 | 5.89e-01 | 0.73200 |
| Interleukin-2 family signaling | 29 | 8.10e-01 | 9.63e-01 | 0.06960 | 6.95e-02 | 0.003270 | 5.18e-01 | 0.97600 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | 12 | 8.11e-01 | 9.63e-01 | 0.10600 | -9.41e-02 | -0.048100 | 5.72e-01 | 0.77300 |
| Trafficking of AMPA receptors | 12 | 8.11e-01 | 9.63e-01 | 0.10600 | -9.41e-02 | -0.048100 | 5.72e-01 | 0.77300 |
| HCMV Early Events | 50 | 8.11e-01 | 9.63e-01 | 0.05340 | 5.24e-02 | -0.010300 | 5.22e-01 | 0.89900 |
| RNA Polymerase I Transcription Termination | 26 | 8.11e-01 | 9.63e-01 | 0.07360 | -7.32e-02 | 0.006890 | 5.18e-01 | 0.95200 |
| Sema4D in semaphorin signaling | 15 | 8.11e-01 | 9.63e-01 | 0.09460 | 8.70e-02 | 0.037300 | 5.60e-01 | 0.80300 |
| Diseases associated with glycosylation precursor biosynthesis | 18 | 8.13e-01 | 9.63e-01 | 0.08700 | 1.21e-02 | 0.086100 | 9.29e-01 | 0.52700 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 14 | 8.16e-01 | 9.63e-01 | 0.10000 | -9.08e-02 | 0.042700 | 5.57e-01 | 0.78200 |
| G alpha (i) signalling events | 112 | 8.17e-01 | 9.63e-01 | 0.03400 | 2.22e-02 | 0.025700 | 6.86e-01 | 0.63900 |
| Lagging Strand Synthesis | 17 | 8.18e-01 | 9.63e-01 | 0.08690 | -7.36e-02 | -0.046100 | 5.99e-01 | 0.74200 |
| HCMV Late Events | 51 | 8.18e-01 | 9.63e-01 | 0.05240 | -4.65e-02 | 0.024200 | 5.66e-01 | 0.76600 |
| Rab regulation of trafficking | 89 | 8.19e-01 | 9.63e-01 | 0.03970 | -3.42e-02 | 0.020100 | 5.78e-01 | 0.74400 |
| Integrin signaling | 17 | 8.21e-01 | 9.63e-01 | 0.09020 | 6.87e-02 | -0.058400 | 6.24e-01 | 0.67700 |
| Platelet Aggregation (Plug Formation) | 17 | 8.21e-01 | 9.63e-01 | 0.09020 | 6.87e-02 | -0.058400 | 6.24e-01 | 0.67700 |
| Pyruvate metabolism | 20 | 8.21e-01 | 9.63e-01 | 0.07920 | 6.63e-02 | 0.043200 | 6.08e-01 | 0.73800 |
| Caspase-mediated cleavage of cytoskeletal proteins | 10 | 8.22e-01 | 9.63e-01 | 0.11200 | -6.67e-02 | -0.089700 | 7.15e-01 | 0.62400 |
| Signaling by NOTCH2 | 18 | 8.22e-01 | 9.63e-01 | 0.08370 | -3.38e-02 | -0.076600 | 8.04e-01 | 0.57400 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 41 | 8.22e-01 | 9.63e-01 | 0.05600 | 5.49e-02 | 0.011300 | 5.44e-01 | 0.90000 |
| RAF-independent MAPK1/3 activation | 20 | 8.27e-01 | 9.68e-01 | 0.07860 | -7.59e-02 | -0.020500 | 5.57e-01 | 0.87400 |
| Voltage gated Potassium channels | 10 | 8.31e-01 | 9.70e-01 | 0.11200 | -1.09e-01 | 0.027900 | 5.52e-01 | 0.87900 |
| XBP1(S) activates chaperone genes | 36 | 8.32e-01 | 9.70e-01 | 0.05940 | -5.55e-02 | 0.021200 | 5.65e-01 | 0.82600 |
| Metabolism of folate and pterines | 11 | 8.34e-01 | 9.70e-01 | 0.10500 | 1.05e-01 | -0.010600 | 5.48e-01 | 0.95100 |
| Interleukin-10 signaling | 13 | 8.35e-01 | 9.70e-01 | 0.09860 | 6.79e-02 | -0.071600 | 6.72e-01 | 0.65500 |
| Methylation | 10 | 8.36e-01 | 9.70e-01 | 0.11000 | -1.09e-01 | 0.008740 | 5.49e-01 | 0.96200 |
| Post-chaperonin tubulin folding pathway | 13 | 8.36e-01 | 9.70e-01 | 0.09350 | -5.89e-02 | -0.072600 | 7.13e-01 | 0.65000 |
| Synthesis of very long-chain fatty acyl-CoAs | 16 | 8.36e-01 | 9.70e-01 | 0.08640 | -1.33e-03 | 0.086400 | 9.93e-01 | 0.55000 |
| Extra-nuclear estrogen signaling | 48 | 8.38e-01 | 9.70e-01 | 0.04900 | -4.77e-02 | -0.011400 | 5.68e-01 | 0.89200 |
| MyD88 cascade initiated on plasma membrane | 65 | 8.39e-01 | 9.70e-01 | 0.04150 | -3.27e-02 | -0.025500 | 6.49e-01 | 0.72300 |
| Toll Like Receptor 10 (TLR10) Cascade | 65 | 8.39e-01 | 9.70e-01 | 0.04150 | -3.27e-02 | -0.025500 | 6.49e-01 | 0.72300 |
| Toll Like Receptor 5 (TLR5) Cascade | 65 | 8.39e-01 | 9.70e-01 | 0.04150 | -3.27e-02 | -0.025500 | 6.49e-01 | 0.72300 |
| Toll Like Receptor 9 (TLR9) Cascade | 70 | 8.40e-01 | 9.70e-01 | 0.04010 | -1.75e-02 | -0.036100 | 8.01e-01 | 0.60200 |
| Ras activation upon Ca2+ influx through NMDA receptor | 10 | 8.40e-01 | 9.70e-01 | 0.10500 | -5.41e-02 | -0.090500 | 7.67e-01 | 0.62000 |
| CD209 (DC-SIGN) signaling | 15 | 8.41e-01 | 9.71e-01 | 0.08990 | -6.43e-02 | 0.062800 | 6.66e-01 | 0.67400 |
| Chaperonin-mediated protein folding | 57 | 8.42e-01 | 9.71e-01 | 0.04450 | 7.65e-03 | 0.043800 | 9.21e-01 | 0.56800 |
| RNA Polymerase I Promoter Escape | 27 | 8.43e-01 | 9.71e-01 | 0.06640 | -5.70e-02 | 0.033900 | 6.08e-01 | 0.76100 |
| Thromboxane signalling through TP receptor | 14 | 8.44e-01 | 9.71e-01 | 0.08850 | 2.43e-02 | 0.085100 | 8.75e-01 | 0.58100 |
| The NLRP3 inflammasome | 12 | 8.45e-01 | 9.71e-01 | 0.09810 | 2.67e-02 | -0.094400 | 8.73e-01 | 0.57100 |
| SLC transporter disorders | 49 | 8.45e-01 | 9.71e-01 | 0.04800 | 2.00e-03 | -0.047900 | 9.81e-01 | 0.56200 |
| Metal ion SLC transporters | 15 | 8.46e-01 | 9.71e-01 | 0.08830 | 6.21e-02 | -0.062800 | 6.78e-01 | 0.67400 |
| EPH-Ephrin signaling | 56 | 8.48e-01 | 9.71e-01 | 0.04510 | -4.25e-02 | 0.015000 | 5.83e-01 | 0.84600 |
| G beta:gamma signalling through PI3Kgamma | 16 | 8.49e-01 | 9.71e-01 | 0.08050 | -5.98e-02 | -0.053900 | 6.79e-01 | 0.70900 |
| FOXO-mediated transcription | 46 | 8.49e-01 | 9.71e-01 | 0.04770 | -4.13e-02 | -0.023800 | 6.28e-01 | 0.78000 |
| FCGR3A-mediated IL10 synthesis | 22 | 8.50e-01 | 9.71e-01 | 0.07150 | -2.78e-02 | 0.065800 | 8.21e-01 | 0.59300 |
| Unwinding of DNA | 10 | 8.51e-01 | 9.71e-01 | 0.10400 | -1.05e-02 | 0.104000 | 9.54e-01 | 0.57000 |
| Signaling by PDGF | 25 | 8.52e-01 | 9.71e-01 | 0.06390 | 5.13e-02 | 0.038000 | 6.57e-01 | 0.74300 |
| Viral Messenger RNA Synthesis | 40 | 8.52e-01 | 9.71e-01 | 0.05300 | -3.59e-02 | 0.039000 | 6.95e-01 | 0.67000 |
| Thrombin signalling through proteinase activated receptors (PARs) | 19 | 8.56e-01 | 9.73e-01 | 0.07540 | -6.77e-02 | 0.033200 | 6.10e-01 | 0.80300 |
| RNA Polymerase III Abortive And Retractive Initiation | 37 | 8.57e-01 | 9.73e-01 | 0.05330 | -1.17e-02 | 0.052000 | 9.02e-01 | 0.58500 |
| RNA Polymerase III Transcription | 37 | 8.57e-01 | 9.73e-01 | 0.05330 | -1.17e-02 | 0.052000 | 9.02e-01 | 0.58500 |
| RUNX3 regulates NOTCH signaling | 11 | 8.58e-01 | 9.73e-01 | 0.09870 | -7.38e-02 | 0.065600 | 6.72e-01 | 0.70700 |
| Sema4D induced cell migration and growth-cone collapse | 12 | 8.59e-01 | 9.74e-01 | 0.09410 | 5.87e-02 | -0.073500 | 7.25e-01 | 0.66000 |
| Heme biosynthesis | 10 | 8.62e-01 | 9.75e-01 | 0.10200 | -4.60e-02 | 0.090600 | 8.01e-01 | 0.62000 |
| COPII-mediated vesicle transport | 51 | 8.63e-01 | 9.75e-01 | 0.04340 | 4.22e-02 | 0.010300 | 6.03e-01 | 0.89900 |
| p53-Dependent G1 DNA Damage Response | 55 | 8.64e-01 | 9.75e-01 | 0.04130 | -3.44e-02 | -0.022800 | 6.60e-01 | 0.77000 |
| p53-Dependent G1/S DNA damage checkpoint | 55 | 8.64e-01 | 9.75e-01 | 0.04130 | -3.44e-02 | -0.022800 | 6.60e-01 | 0.77000 |
| HDMs demethylate histones | 13 | 8.67e-01 | 9.77e-01 | 0.08390 | -7.45e-02 | -0.038600 | 6.42e-01 | 0.81000 |
| Fatty acyl-CoA biosynthesis | 26 | 8.67e-01 | 9.77e-01 | 0.06180 | -5.41e-02 | 0.030000 | 6.33e-01 | 0.79200 |
| TICAM1-dependent activation of IRF3/IRF7 | 12 | 8.69e-01 | 9.78e-01 | 0.09060 | -6.08e-02 | 0.067200 | 7.16e-01 | 0.68700 |
| Orc1 removal from chromatin | 61 | 8.70e-01 | 9.78e-01 | 0.03820 | -2.17e-02 | -0.031400 | 7.69e-01 | 0.67200 |
| Glucagon-type ligand receptors | 13 | 8.71e-01 | 9.78e-01 | 0.08580 | 3.17e-02 | -0.079700 | 8.43e-01 | 0.61900 |
| Transcriptional Regulation by TP53 | 295 | 8.75e-01 | 9.79e-01 | 0.01750 | -2.18e-03 | -0.017400 | 9.49e-01 | 0.61100 |
| Glyoxylate metabolism and glycine degradation | 19 | 8.75e-01 | 9.79e-01 | 0.06790 | 6.74e-02 | 0.008970 | 6.12e-01 | 0.94600 |
| Tie2 Signaling | 10 | 8.77e-01 | 9.79e-01 | 0.09240 | 8.86e-02 | 0.026200 | 6.28e-01 | 0.88600 |
| Deadenylation-dependent mRNA decay | 50 | 8.77e-01 | 9.79e-01 | 0.04300 | 2.31e-02 | -0.036200 | 7.78e-01 | 0.65800 |
| DNA Replication | 110 | 8.77e-01 | 9.79e-01 | 0.02900 | 1.33e-02 | -0.025700 | 8.10e-01 | 0.64200 |
| Downstream signal transduction | 21 | 8.78e-01 | 9.79e-01 | 0.06280 | 5.16e-02 | 0.035800 | 6.82e-01 | 0.77700 |
| Hyaluronan metabolism | 11 | 8.78e-01 | 9.79e-01 | 0.08660 | -5.82e-02 | -0.064000 | 7.38e-01 | 0.71300 |
| Post-translational protein phosphorylation | 32 | 8.80e-01 | 9.80e-01 | 0.05110 | 5.00e-02 | 0.010600 | 6.25e-01 | 0.91700 |
| Switching of origins to a post-replicative state | 79 | 8.81e-01 | 9.80e-01 | 0.03230 | -1.21e-02 | -0.029900 | 8.53e-01 | 0.64700 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 15 | 8.82e-01 | 9.81e-01 | 0.07630 | 3.83e-02 | -0.066100 | 7.98e-01 | 0.65800 |
| Unfolded Protein Response (UPR) | 70 | 8.85e-01 | 9.82e-01 | 0.03370 | 9.27e-03 | 0.032400 | 8.94e-01 | 0.64000 |
| Ion channel transport | 80 | 8.85e-01 | 9.82e-01 | 0.03130 | 2.82e-02 | 0.013600 | 6.63e-01 | 0.83400 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 32 | 8.86e-01 | 9.82e-01 | 0.04890 | -3.21e-02 | -0.036900 | 7.53e-01 | 0.71800 |
| Transcriptional regulation by RUNX3 | 75 | 8.87e-01 | 9.82e-01 | 0.03200 | -1.85e-02 | -0.026200 | 7.83e-01 | 0.69600 |
| Citric acid cycle (TCA cycle) | 19 | 8.88e-01 | 9.82e-01 | 0.06400 | 1.03e-02 | 0.063200 | 9.38e-01 | 0.63400 |
| Transcription of the HIV genome | 55 | 8.93e-01 | 9.85e-01 | 0.03750 | -3.70e-02 | 0.006020 | 6.36e-01 | 0.93900 |
| HCMV Infection | 71 | 8.93e-01 | 9.85e-01 | 0.03190 | -2.67e-02 | -0.017600 | 6.98e-01 | 0.79800 |
| RET signaling | 22 | 8.94e-01 | 9.85e-01 | 0.05730 | -2.36e-02 | -0.052200 | 8.48e-01 | 0.67200 |
| Transcriptional regulation by RUNX1 | 133 | 8.94e-01 | 9.85e-01 | 0.02440 | 1.42e-02 | -0.019800 | 7.78e-01 | 0.69400 |
| Synthesis of PA | 18 | 8.95e-01 | 9.85e-01 | 0.06260 | 4.41e-02 | 0.044400 | 7.46e-01 | 0.74500 |
| Gap junction trafficking and regulation | 10 | 8.96e-01 | 9.85e-01 | 0.08350 | -4.51e-02 | -0.070300 | 8.05e-01 | 0.70000 |
| Synthesis of DNA | 103 | 8.97e-01 | 9.85e-01 | 0.02610 | -1.45e-02 | -0.021700 | 8.00e-01 | 0.70500 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 18 | 8.97e-01 | 9.85e-01 | 0.06320 | -6.31e-02 | -0.004100 | 6.43e-01 | 0.97600 |
| DNA strand elongation | 27 | 9.01e-01 | 9.88e-01 | 0.05120 | -5.03e-02 | 0.009440 | 6.51e-01 | 0.93200 |
| Striated Muscle Contraction | 10 | 9.02e-01 | 9.88e-01 | 0.08250 | -1.15e-02 | -0.081600 | 9.50e-01 | 0.65500 |
| Regulation of insulin secretion | 38 | 9.03e-01 | 9.88e-01 | 0.04180 | -4.08e-02 | -0.009400 | 6.64e-01 | 0.92000 |
| Epigenetic regulation of gene expression | 75 | 9.05e-01 | 9.88e-01 | 0.02930 | -2.60e-02 | -0.013600 | 6.98e-01 | 0.84000 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 10 | 9.07e-01 | 9.88e-01 | 0.08170 | 2.11e-02 | -0.078900 | 9.08e-01 | 0.66600 |
| Glucagon signaling in metabolic regulation | 17 | 9.08e-01 | 9.88e-01 | 0.06080 | 1.65e-02 | 0.058500 | 9.06e-01 | 0.67600 |
| Prostacyclin signalling through prostacyclin receptor | 11 | 9.08e-01 | 9.88e-01 | 0.07580 | 7.51e-02 | 0.010800 | 6.67e-01 | 0.95000 |
| Endosomal/Vacuolar pathway | 11 | 9.08e-01 | 9.88e-01 | 0.07740 | -7.44e-02 | 0.021400 | 6.69e-01 | 0.90200 |
| L1CAM interactions | 40 | 9.09e-01 | 9.88e-01 | 0.03950 | -3.89e-02 | -0.007390 | 6.71e-01 | 0.93600 |
| G1/S DNA Damage Checkpoints | 57 | 9.11e-01 | 9.88e-01 | 0.03240 | -2.58e-02 | -0.019600 | 7.37e-01 | 0.79800 |
| NoRC negatively regulates rRNA expression | 42 | 9.12e-01 | 9.88e-01 | 0.03890 | -3.74e-02 | 0.010600 | 6.75e-01 | 0.90500 |
| Metabolism of non-coding RNA | 47 | 9.12e-01 | 9.88e-01 | 0.03720 | 2.43e-02 | -0.028200 | 7.73e-01 | 0.73800 |
| snRNP Assembly | 47 | 9.12e-01 | 9.88e-01 | 0.03720 | 2.43e-02 | -0.028200 | 7.73e-01 | 0.73800 |
| B-WICH complex positively regulates rRNA expression | 27 | 9.12e-01 | 9.88e-01 | 0.04890 | -3.31e-02 | 0.036000 | 7.66e-01 | 0.74600 |
| RNA Polymerase III Transcription Termination | 20 | 9.13e-01 | 9.88e-01 | 0.05640 | -3.67e-02 | 0.042800 | 7.77e-01 | 0.74000 |
| Class I peroxisomal membrane protein import | 19 | 9.14e-01 | 9.88e-01 | 0.05510 | 2.49e-02 | 0.049100 | 8.51e-01 | 0.71100 |
| Hyaluronan uptake and degradation | 10 | 9.15e-01 | 9.88e-01 | 0.07670 | -7.13e-03 | -0.076400 | 9.69e-01 | 0.67600 |
| Negative epigenetic regulation of rRNA expression | 43 | 9.16e-01 | 9.88e-01 | 0.03800 | -2.81e-02 | 0.025500 | 7.50e-01 | 0.77200 |
| Interleukin receptor SHC signaling | 16 | 9.18e-01 | 9.90e-01 | 0.05910 | 9.54e-03 | 0.058300 | 9.47e-01 | 0.68600 |
| DNA Replication Pre-Initiation | 72 | 9.20e-01 | 9.90e-01 | 0.02710 | -1.75e-02 | -0.020700 | 7.98e-01 | 0.76200 |
| Association of TriC/CCT with target proteins during biosynthesis | 29 | 9.21e-01 | 9.90e-01 | 0.04470 | -3.13e-02 | 0.031900 | 7.71e-01 | 0.76600 |
| SUMOylation of RNA binding proteins | 42 | 9.22e-01 | 9.90e-01 | 0.03520 | 2.73e-02 | 0.022100 | 7.60e-01 | 0.80400 |
| Retinoid metabolism and transport | 10 | 9.22e-01 | 9.90e-01 | 0.07210 | 3.05e-02 | 0.065300 | 8.68e-01 | 0.72100 |
| Diseases of metabolism | 120 | 9.24e-01 | 9.90e-01 | 0.02150 | -2.01e-02 | 0.007690 | 7.05e-01 | 0.88500 |
| PRC2 methylates histones and DNA | 11 | 9.26e-01 | 9.90e-01 | 0.06870 | -1.01e-02 | 0.067900 | 9.54e-01 | 0.69700 |
| O-linked glycosylation of mucins | 26 | 9.26e-01 | 9.90e-01 | 0.04520 | -4.14e-02 | 0.018000 | 7.15e-01 | 0.87400 |
| Asparagine N-linked glycosylation | 223 | 9.28e-01 | 9.90e-01 | 0.01490 | -6.24e-03 | -0.013500 | 8.73e-01 | 0.73100 |
| FOXO-mediated transcription of cell cycle genes | 13 | 9.28e-01 | 9.90e-01 | 0.06230 | 1.19e-02 | -0.061200 | 9.41e-01 | 0.70300 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 71 | 9.30e-01 | 9.90e-01 | 0.02550 | -1.98e-02 | -0.016100 | 7.74e-01 | 0.81500 |
| Toll Like Receptor 2 (TLR2) Cascade | 71 | 9.30e-01 | 9.90e-01 | 0.02550 | -1.98e-02 | -0.016100 | 7.74e-01 | 0.81500 |
| Toll Like Receptor TLR1:TLR2 Cascade | 71 | 9.30e-01 | 9.90e-01 | 0.02550 | -1.98e-02 | -0.016100 | 7.74e-01 | 0.81500 |
| Toll Like Receptor TLR6:TLR2 Cascade | 71 | 9.30e-01 | 9.90e-01 | 0.02550 | -1.98e-02 | -0.016100 | 7.74e-01 | 0.81500 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 33 | 9.33e-01 | 9.91e-01 | 0.03820 | -1.44e-02 | 0.035400 | 8.86e-01 | 0.72500 |
| Metabolism of porphyrins | 15 | 9.33e-01 | 9.91e-01 | 0.05700 | -3.72e-02 | 0.043100 | 8.03e-01 | 0.77300 |
| Metabolism of steroid hormones | 12 | 9.35e-01 | 9.91e-01 | 0.06260 | 5.45e-02 | -0.030800 | 7.44e-01 | 0.85400 |
| STING mediated induction of host immune responses | 10 | 9.35e-01 | 9.91e-01 | 0.06850 | -3.60e-02 | 0.058300 | 8.44e-01 | 0.75000 |
| RNA Polymerase II Pre-transcription Events | 65 | 9.38e-01 | 9.92e-01 | 0.02590 | -3.32e-03 | 0.025700 | 9.63e-01 | 0.72100 |
| Activation of BAD and translocation to mitochondria | 14 | 9.39e-01 | 9.92e-01 | 0.05400 | -5.12e-02 | -0.017300 | 7.40e-01 | 0.91100 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | 18 | 9.39e-01 | 9.92e-01 | 0.04740 | 4.33e-02 | 0.019200 | 7.51e-01 | 0.88800 |
| Degradation of the extracellular matrix | 35 | 9.39e-01 | 9.92e-01 | 0.03540 | -2.15e-02 | 0.028100 | 8.26e-01 | 0.77400 |
| Sialic acid metabolism | 23 | 9.42e-01 | 9.93e-01 | 0.04220 | 1.53e-02 | -0.039300 | 8.99e-01 | 0.74400 |
| Leading Strand Synthesis | 12 | 9.43e-01 | 9.93e-01 | 0.05600 | -1.82e-02 | -0.053000 | 9.13e-01 | 0.75100 |
| Polymerase switching | 12 | 9.43e-01 | 9.93e-01 | 0.05600 | -1.82e-02 | -0.053000 | 9.13e-01 | 0.75100 |
| PI Metabolism | 59 | 9.46e-01 | 9.93e-01 | 0.02540 | -2.38e-02 | 0.008770 | 7.52e-01 | 0.90700 |
| ZBP1(DAI) mediated induction of type I IFNs | 17 | 9.47e-01 | 9.93e-01 | 0.04640 | 2.66e-03 | -0.046400 | 9.85e-01 | 0.74100 |
| Long-term potentiation | 11 | 9.47e-01 | 9.93e-01 | 0.05720 | -5.72e-02 | -0.000996 | 7.43e-01 | 0.99500 |
| Frs2-mediated activation | 11 | 9.50e-01 | 9.93e-01 | 0.05700 | 3.33e-02 | -0.046300 | 8.48e-01 | 0.79100 |
| Phase II - Conjugation of compounds | 45 | 9.51e-01 | 9.93e-01 | 0.02730 | 2.73e-02 | 0.000623 | 7.52e-01 | 0.99400 |
| Protein folding | 63 | 9.53e-01 | 9.93e-01 | 0.02330 | -1.40e-02 | 0.018600 | 8.48e-01 | 0.79900 |
| Synthesis of PIPs at the plasma membrane | 36 | 9.55e-01 | 9.93e-01 | 0.02890 | -2.71e-02 | -0.009990 | 7.79e-01 | 0.91700 |
| Signaling by NTRK3 (TRKC) | 12 | 9.55e-01 | 9.93e-01 | 0.05120 | -4.99e-02 | 0.011500 | 7.65e-01 | 0.94500 |
| Miscellaneous transport and binding events | 14 | 9.56e-01 | 9.93e-01 | 0.04620 | 4.55e-02 | 0.007520 | 7.68e-01 | 0.96100 |
| Aquaporin-mediated transport | 22 | 9.57e-01 | 9.93e-01 | 0.03660 | -2.05e-03 | 0.036500 | 9.87e-01 | 0.76700 |
| Vasopressin regulates renal water homeostasis via Aquaporins | 21 | 9.57e-01 | 9.93e-01 | 0.03810 | -1.95e-02 | 0.032800 | 8.77e-01 | 0.79500 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | 10 | 9.58e-01 | 9.93e-01 | 0.05460 | 2.71e-02 | -0.047300 | 8.82e-01 | 0.79600 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 11 | 9.58e-01 | 9.93e-01 | 0.05150 | -1.38e-02 | 0.049600 | 9.37e-01 | 0.77600 |
| Adrenaline,noradrenaline inhibits insulin secretion | 14 | 9.59e-01 | 9.93e-01 | 0.04560 | -3.83e-02 | 0.024700 | 8.04e-01 | 0.87300 |
| Iron uptake and transport | 38 | 9.65e-01 | 9.93e-01 | 0.02470 | 2.18e-02 | 0.011500 | 8.16e-01 | 0.90200 |
| Integrin cell surface interactions | 25 | 9.67e-01 | 9.93e-01 | 0.02980 | -2.93e-02 | -0.005770 | 8.00e-01 | 0.96000 |
| Semaphorin interactions | 39 | 9.67e-01 | 9.93e-01 | 0.02450 | 8.53e-03 | -0.023000 | 9.27e-01 | 0.80400 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | 13 | 9.67e-01 | 9.93e-01 | 0.04150 | -1.54e-03 | -0.041500 | 9.92e-01 | 0.79600 |
| Synthesis of PIPs at the Golgi membrane | 12 | 9.67e-01 | 9.93e-01 | 0.04410 | -3.27e-02 | 0.029600 | 8.44e-01 | 0.85900 |
| MyD88-independent TLR4 cascade | 75 | 9.68e-01 | 9.93e-01 | 0.01690 | -5.17e-03 | -0.016100 | 9.38e-01 | 0.81000 |
| TRIF(TICAM1)-mediated TLR4 signaling | 75 | 9.68e-01 | 9.93e-01 | 0.01690 | -5.17e-03 | -0.016100 | 9.38e-01 | 0.81000 |
| Regulation of HSF1-mediated heat shock response | 66 | 9.70e-01 | 9.93e-01 | 0.01790 | -1.67e-02 | 0.006560 | 8.15e-01 | 0.92700 |
| G-protein beta:gamma signalling | 20 | 9.71e-01 | 9.93e-01 | 0.03190 | -1.27e-02 | 0.029300 | 9.22e-01 | 0.82100 |
| LDL clearance | 13 | 9.71e-01 | 9.93e-01 | 0.03800 | -1.68e-02 | -0.034100 | 9.16e-01 | 0.83200 |
| Signaling by FGFR3 | 26 | 9.72e-01 | 9.93e-01 | 0.02670 | -2.48e-02 | -0.010000 | 8.27e-01 | 0.93000 |
| Cell-cell junction organization | 12 | 9.73e-01 | 9.93e-01 | 0.03870 | -3.71e-02 | -0.011200 | 8.24e-01 | 0.94700 |
| Peroxisomal protein import | 48 | 9.74e-01 | 9.93e-01 | 0.01940 | 1.93e-02 | -0.002190 | 8.17e-01 | 0.97900 |
| Neddylation | 179 | 9.74e-01 | 9.93e-01 | 0.01010 | -4.54e-03 | 0.009060 | 9.17e-01 | 0.83500 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 15 | 9.75e-01 | 9.93e-01 | 0.03350 | -3.33e-02 | -0.003140 | 8.23e-01 | 0.98300 |
| Potassium Channels | 26 | 9.75e-01 | 9.93e-01 | 0.02600 | 2.22e-02 | -0.013600 | 8.45e-01 | 0.90400 |
| HIV Transcription Initiation | 37 | 9.75e-01 | 9.93e-01 | 0.02110 | -2.28e-03 | -0.021000 | 9.81e-01 | 0.82600 |
| RNA Polymerase II HIV Promoter Escape | 37 | 9.75e-01 | 9.93e-01 | 0.02110 | -2.28e-03 | -0.021000 | 9.81e-01 | 0.82600 |
| RNA Polymerase II Promoter Escape | 37 | 9.75e-01 | 9.93e-01 | 0.02110 | -2.28e-03 | -0.021000 | 9.81e-01 | 0.82600 |
| RNA Polymerase II Transcription Initiation | 37 | 9.75e-01 | 9.93e-01 | 0.02110 | -2.28e-03 | -0.021000 | 9.81e-01 | 0.82600 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | 37 | 9.75e-01 | 9.93e-01 | 0.02110 | -2.28e-03 | -0.021000 | 9.81e-01 | 0.82600 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 37 | 9.75e-01 | 9.93e-01 | 0.02110 | -2.28e-03 | -0.021000 | 9.81e-01 | 0.82600 |
| NOTCH3 Intracellular Domain Regulates Transcription | 15 | 9.76e-01 | 9.93e-01 | 0.03220 | -1.63e-02 | -0.027700 | 9.13e-01 | 0.85300 |
| tRNA processing | 93 | 9.77e-01 | 9.93e-01 | 0.01330 | 1.04e-02 | -0.008420 | 8.63e-01 | 0.88900 |
| Transport to the Golgi and subsequent modification | 127 | 9.77e-01 | 9.93e-01 | 0.01080 | 5.51e-03 | 0.009270 | 9.15e-01 | 0.85700 |
| Regulation of TP53 Activity | 131 | 9.80e-01 | 9.94e-01 | 0.01030 | 8.55e-03 | -0.005770 | 8.66e-01 | 0.91000 |
| Arachidonic acid metabolism | 20 | 9.81e-01 | 9.94e-01 | 0.02570 | 2.49e-02 | -0.006330 | 8.47e-01 | 0.96100 |
| Toll Like Receptor 4 (TLR4) Cascade | 93 | 9.81e-01 | 9.94e-01 | 0.01170 | 1.17e-02 | -0.000990 | 8.46e-01 | 0.98700 |
| Recycling pathway of L1 | 16 | 9.82e-01 | 9.94e-01 | 0.02820 | -2.08e-02 | 0.019100 | 8.86e-01 | 0.89500 |
| Elastic fibre formation | 17 | 9.82e-01 | 9.94e-01 | 0.02680 | -2.66e-02 | 0.003120 | 8.50e-01 | 0.98200 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 23 | 9.83e-01 | 9.94e-01 | 0.02190 | 4.45e-03 | 0.021400 | 9.71e-01 | 0.85900 |
| DNA Double Strand Break Response | 34 | 9.85e-01 | 9.95e-01 | 0.01680 | 6.09e-03 | 0.015700 | 9.51e-01 | 0.87500 |
| Synthesis of substrates in N-glycan biosythesis | 49 | 9.87e-01 | 9.96e-01 | 0.01320 | 1.31e-02 | 0.001910 | 8.74e-01 | 0.98200 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | 10 | 9.89e-01 | 9.96e-01 | 0.02700 | 2.10e-02 | 0.016900 | 9.08e-01 | 0.92600 |
| MAPK6/MAPK4 signaling | 67 | 9.89e-01 | 9.96e-01 | 0.01020 | 4.84e-03 | 0.008970 | 9.46e-01 | 0.89900 |
| Signaling by FGFR1 | 28 | 9.90e-01 | 9.96e-01 | 0.01600 | 2.62e-03 | -0.015700 | 9.81e-01 | 0.88500 |
| Transcriptional regulation by small RNAs | 43 | 9.93e-01 | 9.97e-01 | 0.01080 | -2.04e-03 | 0.010600 | 9.82e-01 | 0.90400 |
| Toll Like Receptor 3 (TLR3) Cascade | 75 | 9.93e-01 | 9.97e-01 | 0.00783 | -2.55e-03 | -0.007410 | 9.70e-01 | 0.91200 |
| Regulation of KIT signaling | 11 | 9.93e-01 | 9.97e-01 | 0.01980 | -1.65e-02 | -0.011000 | 9.25e-01 | 0.94900 |
| Listeria monocytogenes entry into host cells | 14 | 9.95e-01 | 9.98e-01 | 0.01510 | -1.15e-02 | 0.009750 | 9.41e-01 | 0.95000 |
| VEGFR2 mediated cell proliferation | 16 | 9.97e-01 | 9.99e-01 | 0.01090 | -1.00e-02 | -0.004120 | 9.45e-01 | 0.97700 |
| Interleukin-4 and Interleukin-13 signaling | 48 | 9.99e-01 | 9.99e-01 | 0.00420 | -3.43e-03 | 0.002430 | 9.67e-01 | 0.97700 |
| Negative regulation of MET activity | 16 | 9.99e-01 | 9.99e-01 | 0.00652 | 1.91e-03 | -0.006230 | 9.89e-01 | 0.96600 |
Detailed Gene set reports
Eukaryotic Translation Elongation
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 7.59e-37 |
| p.adjustMANOVA | 8.53e-34 |
| s.dist | 0.884 |
| s.RNA | -0.879 |
| s.meth | -0.0892 |
| p.RNA | 3.16e-37 |
| p.meth | 0.198 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EEF1A1 | -4296 | 2014 |
| EEF1B2 | -4632 | 5616 |
| EEF1D | -4570 | 7650 |
| EEF1G | -4658 | 723 |
| EEF2 | -4566 | 1316 |
| FAU | -4597 | 5991 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Peptide chain elongation
| metric | value |
|---|---|
| setSize | 67 |
| pMANOVA | 5.1e-35 |
| p.adjustMANOVA | 2.86e-32 |
| s.dist | 0.88 |
| s.RNA | -0.874 |
| s.meth | -0.102 |
| p.RNA | 2.84e-35 |
| p.meth | 0.151 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EEF1A1 | -4296 | 2014 |
| EEF2 | -4566 | 1316 |
| FAU | -4597 | 5991 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Formation of a pool of free 40S subunits
| metric | value |
|---|---|
| setSize | 76 |
| pMANOVA | 2.34e-33 |
| p.adjustMANOVA | 8.75e-31 |
| s.dist | 0.807 |
| s.RNA | -0.803 |
| s.meth | -0.0816 |
| p.RNA | 8.55e-34 |
| p.meth | 0.22 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| FAU | -4597 | 5991 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Selenocysteine synthesis
| metric | value |
|---|---|
| setSize | 68 |
| pMANOVA | 7.34e-33 |
| p.adjustMANOVA | 2.06e-30 |
| s.dist | 0.847 |
| s.RNA | -0.845 |
| s.meth | -0.065 |
| p.RNA | 1.6e-33 |
| p.meth | 0.355 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EEFSEC | -1276 | 6233 |
| FAU | -4597 | 5991 |
| PSTK | 687 | 7792 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SEPHS2 | -3131 | 4134 |
| UBA52 | -4418 | 4404 |
Eukaryotic Translation Termination
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 6.85e-32 |
| p.adjustMANOVA | 1.54e-29 |
| s.dist | 0.822 |
| s.RNA | -0.818 |
| s.meth | -0.0808 |
| p.RNA | 2.23e-32 |
| p.meth | 0.244 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| APEH | -3410 | 432 |
| ETF1 | 2978 | 7120 |
| FAU | -4597 | 5991 |
| GSPT1 | 3544 | 4369 |
| N6AMT1 | -1220 | 326 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| TRMT112 | -4628 | 7797 |
| UBA52 | -4418 | 4404 |
Viral mRNA Translation
| metric | value |
|---|---|
| setSize | 67 |
| pMANOVA | 1.17e-31 |
| p.adjustMANOVA | 2.2e-29 |
| s.dist | 0.837 |
| s.RNA | -0.833 |
| s.meth | -0.0807 |
| p.RNA | 3.65e-32 |
| p.meth | 0.254 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| DNAJC3 | 3023 | 8319 |
| FAU | -4597 | 5991 |
| GRSF1 | 865 | 1474 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Selenoamino acid metabolism
| metric | value |
|---|---|
| setSize | 76 |
| pMANOVA | 2.49e-30 |
| p.adjustMANOVA | 4e-28 |
| s.dist | 0.769 |
| s.RNA | -0.764 |
| s.meth | -0.0834 |
| p.RNA | 9.51e-31 |
| p.meth | 0.21 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AHCY | -4193 | 1896 |
| AIMP2 | 1455 | 6011 |
| CTH | 2789 | 1184 |
| EEF1E1 | -132 | 3266 |
| EEFSEC | -1276 | 6233 |
| FAU | -4597 | 5991 |
| GSR | -1273 | 1990 |
| PAPSS1 | 1440 | 6222 |
| PSTK | 687 | 7792 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SCLY | -1972 | 681 |
| SEPHS2 | -3131 | 4134 |
| TXNRD1 | -851 | 214 |
| UBA52 | -4418 | 4404 |
L13a-mediated translational silencing of Ceruloplasmin expression
| metric | value |
|---|---|
| setSize | 85 |
| pMANOVA | 3e-29 |
| p.adjustMANOVA | 4.22e-27 |
| s.dist | 0.715 |
| s.RNA | -0.713 |
| s.meth | -0.0534 |
| p.RNA | 5.85e-30 |
| p.meth | 0.396 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| FAU | -4597 | 5991 |
| PABPC1 | 1884 | 3737 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
GTP hydrolysis and joining of the 60S ribosomal subunit
| metric | value |
|---|---|
| setSize | 86 |
| pMANOVA | 6e-28 |
| p.adjustMANOVA | 7.5e-26 |
| s.dist | 0.695 |
| s.RNA | -0.694 |
| s.meth | -0.0431 |
| p.RNA | 9.45e-29 |
| p.meth | 0.49 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| EIF5 | 2432 | 7143 |
| EIF5B | 3852 | 4202 |
| FAU | -4597 | 5991 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
| metric | value |
|---|---|
| setSize | 72 |
| pMANOVA | 1.06e-27 |
| p.adjustMANOVA | 1.19e-25 |
| s.dist | 0.754 |
| s.RNA | -0.751 |
| s.meth | -0.0731 |
| p.RNA | 2.9e-28 |
| p.meth | 0.285 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF4G1 | -2084 | 3220 |
| ETF1 | 2978 | 7120 |
| FAU | -4597 | 5991 |
| GSPT1 | 3544 | 4369 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| PABPC1 | 1884 | 3737 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
| UPF1 | -2034 | 712 |
Cap-dependent Translation Initiation
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 2.18e-26 |
| p.adjustMANOVA | 2.05e-24 |
| s.dist | 0.649 |
| s.RNA | -0.648 |
| s.meth | -0.0402 |
| p.RNA | 3.37e-27 |
| p.meth | 0.504 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2B1 | 2175 | 5018 |
| EIF2B2 | -3338 | 6512 |
| EIF2B3 | 2177 | 810 |
| EIF2B4 | -2557 | 5664 |
| EIF2B5 | -1234 | 837 |
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4EBP1 | -1795 | 3840 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| EIF5 | 2432 | 7143 |
| EIF5B | 3852 | 4202 |
| FAU | -4597 | 5991 |
| PABPC1 | 1884 | 3737 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Eukaryotic Translation Initiation
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 2.18e-26 |
| p.adjustMANOVA | 2.05e-24 |
| s.dist | 0.649 |
| s.RNA | -0.648 |
| s.meth | -0.0402 |
| p.RNA | 3.37e-27 |
| p.meth | 0.504 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2B1 | 2175 | 5018 |
| EIF2B2 | -3338 | 6512 |
| EIF2B3 | 2177 | 810 |
| EIF2B4 | -2557 | 5664 |
| EIF2B5 | -1234 | 837 |
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4EBP1 | -1795 | 3840 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| EIF5 | 2432 | 7143 |
| EIF5B | 3852 | 4202 |
| FAU | -4597 | 5991 |
| PABPC1 | 1884 | 3737 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| UBA52 | -4418 | 4404 |
Response of EIF2AK4 (GCN2) to amino acid deficiency
| metric | value |
|---|---|
| setSize | 76 |
| pMANOVA | 3.13e-26 |
| p.adjustMANOVA | 2.71e-24 |
| s.dist | 0.714 |
| s.RNA | -0.712 |
| s.meth | -0.0628 |
| p.RNA | 7.07e-27 |
| p.meth | 0.345 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ASNS | 1581 | 2242 |
| ATF3 | 4330 | 5006 |
| ATF4 | -1992 | 3847 |
| CEBPB | 37 | 2587 |
| CEBPG | 2366 | 5011 |
| DDIT3 | 1184 | 1641 |
| EIF2AK4 | -1627 | 6865 |
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| FAU | -4597 | 5991 |
| GCN1 | -1543 | 7280 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| TRIB3 | 1743 | 563 |
| UBA52 | -4418 | 4404 |
SRP-dependent cotranslational protein targeting to membrane
| metric | value |
|---|---|
| setSize | 85 |
| pMANOVA | 6.98e-22 |
| p.adjustMANOVA | 5.61e-20 |
| s.dist | 0.614 |
| s.RNA | -0.607 |
| s.meth | -0.0906 |
| p.RNA | 3.75e-22 |
| p.meth | 0.15 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| FAU | -4597 | 5991 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPN1 | -1640 | 6578 |
| RPN2 | 596 | 3798 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SEC11A | -824 | 6712 |
| SEC11C | 2870 | 5343 |
| SEC61A1 | -446 | 5888 |
| SEC61A2 | 2578 | 6659 |
| SEC61B | -4340 | 456 |
| SEC61G | 2509 | 2870 |
| SPCS2 | 2462 | 7887 |
| SPCS3 | 3891 | 4022 |
| SRP14 | 188 | 5822 |
| SRP19 | 4317 | 1191 |
| SRP54 | 4410 | 3638 |
| SRP68 | -571 | 267 |
| SRP72 | 1990 | 2265 |
| SRPRB | 931 | 2077 |
| SSR1 | 1746 | 94 |
| SSR2 | -3127 | 1250 |
| SSR3 | 2437 | 21 |
| TRAM1 | 3449 | 636 |
| UBA52 | -4418 | 4404 |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
| metric | value |
|---|---|
| setSize | 86 |
| pMANOVA | 1.12e-21 |
| p.adjustMANOVA | 7.87e-20 |
| s.dist | 0.609 |
| s.RNA | -0.607 |
| s.meth | -0.0534 |
| p.RNA | 2.27e-22 |
| p.meth | 0.393 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| SMG6 | -2308 | -684 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
| SMG5 | -2243 | -216 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| CASC3 | -2347 | 3341 |
| DCP1A | 2304 | 4270 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| ETF1 | 2978 | 7120 |
| FAU | -4597 | 5991 |
| GSPT1 | 3544 | 4369 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| PABPC1 | 1884 | 3737 |
| PNRC2 | 3771 | 3788 |
| PPP2CA | 206 | 7715 |
| PPP2R2A | 4512 | 545 |
| RNPS1 | -2236 | 2194 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SMG1 | 2219 | 8338 |
| SMG5 | -2243 | -216 |
| SMG6 | -2308 | -684 |
| SMG7 | 3207 | 3120 |
| SMG8 | 1402 | 8016 |
| UBA52 | -4418 | 4404 |
| UPF1 | -2034 | 712 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
Nonsense-Mediated Decay (NMD)
| metric | value |
|---|---|
| setSize | 86 |
| pMANOVA | 1.12e-21 |
| p.adjustMANOVA | 7.87e-20 |
| s.dist | 0.609 |
| s.RNA | -0.607 |
| s.meth | -0.0534 |
| p.RNA | 2.27e-22 |
| p.meth | 0.393 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| SMG6 | -2308 | -684 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
| SMG5 | -2243 | -216 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| CASC3 | -2347 | 3341 |
| DCP1A | 2304 | 4270 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| ETF1 | 2978 | 7120 |
| FAU | -4597 | 5991 |
| GSPT1 | 3544 | 4369 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| PABPC1 | 1884 | 3737 |
| PNRC2 | 3771 | 3788 |
| PPP2CA | 206 | 7715 |
| PPP2R2A | 4512 | 545 |
| RNPS1 | -2236 | 2194 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SMG1 | 2219 | 8338 |
| SMG5 | -2243 | -216 |
| SMG6 | -2308 | -684 |
| SMG7 | 3207 | 3120 |
| SMG8 | 1402 | 8016 |
| UBA52 | -4418 | 4404 |
| UPF1 | -2034 | 712 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
Translation
| metric | value |
|---|---|
| setSize | 234 |
| pMANOVA | 2.81e-21 |
| p.adjustMANOVA | 1.86e-19 |
| s.dist | 0.366 |
| s.RNA | -0.356 |
| s.meth | -0.087 |
| p.RNA | 1.09e-20 |
| p.meth | 0.0228 |
| Gene | RNA | meth |
|---|---|---|
| MRPL23 | -4107 | -853 |
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| MRPL27 | -2508 | -718 |
| MRPS2 | -4061 | -421 |
| MRPL45 | -2529 | -666 |
| RPS23 | -4487 | -355 |
| MRPL9 | -3077 | -494 |
| RPS8 | -4077 | -349 |
| MRPL20 | -1735 | -789 |
| GADD45GIP1 | -3882 | -350 |
| FARS2 | -2035 | -607 |
| MRPL51 | -3529 | -289 |
| MRPL37 | -2893 | -302 |
| RPL36 | -4617 | -158 |
| MRPL2 | -1326 | -436 |
| MRPL52 | -2450 | -146 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AARS2 | -2247 | 2842 |
| AIMP2 | 1455 | 6011 |
| APEH | -3410 | 432 |
| AURKAIP1 | -4305 | 3883 |
| CARS2 | -1179 | 171 |
| CHCHD1 | -4141 | 3680 |
| DAP3 | -1774 | 143 |
| DARS2 | 1671 | 8397 |
| EARS2 | -690 | 783 |
| EEF1A1 | -4296 | 2014 |
| EEF1B2 | -4632 | 5616 |
| EEF1D | -4570 | 7650 |
| EEF1E1 | -132 | 3266 |
| EEF1G | -4658 | 723 |
| EEF2 | -4566 | 1316 |
| EIF2B1 | 2175 | 5018 |
| EIF2B2 | -3338 | 6512 |
| EIF2B3 | 2177 | 810 |
| EIF2B4 | -2557 | 5664 |
| EIF2B5 | -1234 | 837 |
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4EBP1 | -1795 | 3840 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| EIF5 | 2432 | 7143 |
| EIF5B | 3852 | 4202 |
| ERAL1 | -149 | 3775 |
| ETF1 | 2978 | 7120 |
| FARS2 | -2035 | -607 |
| FARSA | -4056 | 5701 |
| FARSB | 3336 | 5328 |
| FAU | -4597 | 5991 |
| GADD45GIP1 | -3882 | -350 |
| GFM1 | -21 | 1365 |
| GFM2 | 3218 | 4081 |
| GSPT1 | 3544 | 4369 |
| HARS2 | 1454 | 1362 |
| IARS2 | -31 | 2685 |
| LARS2 | -3675 | 1517 |
| MARS2 | -1412 | 2590 |
| MRPL1 | 3546 | 218 |
| MRPL10 | 190 | 2279 |
| MRPL11 | -4247 | 4034 |
| MRPL12 | -4408 | 8276 |
| MRPL13 | 3162 | 7625 |
| MRPL14 | -3960 | 6345 |
| MRPL15 | -1773 | 5045 |
| MRPL16 | -523 | 7696 |
| MRPL18 | -756 | 3878 |
| MRPL19 | 2802 | 6054 |
| MRPL2 | -1326 | -436 |
| MRPL20 | -1735 | -789 |
| MRPL21 | -1930 | 1605 |
| MRPL22 | 340 | 6263 |
| MRPL23 | -4107 | -853 |
| MRPL24 | -4629 | 448 |
| MRPL27 | -2508 | -718 |
| MRPL30 | -330 | 5691 |
| MRPL32 | 1203 | 914 |
| MRPL33 | -1670 | 2858 |
| MRPL34 | -4554 | 789 |
| MRPL35 | 1364 | 463 |
| MRPL36 | -3032 | 8337 |
| MRPL37 | -2893 | -302 |
| MRPL38 | -3782 | 6626 |
| MRPL39 | 3247 | 4899 |
| MRPL4 | -39 | 7667 |
| MRPL41 | -2545 | 1540 |
| MRPL42 | 4573 | 3628 |
| MRPL43 | -4644 | 3498 |
| MRPL44 | 1858 | 2675 |
| MRPL45 | -2529 | -666 |
| MRPL46 | -1802 | 5122 |
| MRPL47 | 3068 | 6845 |
| MRPL48 | -1756 | 5652 |
| MRPL49 | -3523 | 6807 |
| MRPL50 | 1441 | 3835 |
| MRPL51 | -3529 | -289 |
| MRPL52 | -2450 | -146 |
| MRPL53 | -4115 | 971 |
| MRPL54 | -4663 | 1889 |
| MRPL55 | -3531 | 7479 |
| MRPL57 | -3056 | 4246 |
| MRPL9 | -3077 | -494 |
| MRPS10 | 3205 | -389 |
| MRPS11 | -872 | 1648 |
| MRPS12 | -4419 | 1712 |
| MRPS14 | 2200 | 1977 |
| MRPS15 | -3379 | 3677 |
| MRPS16 | -2474 | 2543 |
| MRPS17 | -205 | 3827 |
| MRPS18A | -781 | 7695 |
| MRPS18B | 272 | -766 |
| MRPS18C | 1393 | 6987 |
| MRPS2 | -4061 | -421 |
| MRPS21 | -4114 | 1464 |
| MRPS22 | 2497 | 6094 |
| MRPS23 | -2181 | 2254 |
| MRPS24 | -4381 | 3376 |
| MRPS25 | -473 | 6261 |
| MRPS26 | -4382 | 8045 |
| MRPS27 | 453 | 1421 |
| MRPS28 | -1744 | 3713 |
| MRPS30 | -726 | 5477 |
| MRPS31 | 2768 | 6499 |
| MRPS33 | -2318 | 3752 |
| MRPS34 | -4662 | 6347 |
| MRPS35 | 3530 | 3581 |
| MRPS36 | -59 | 2215 |
| MRPS5 | 1087 | 1128 |
| MRPS6 | -3427 | 3325 |
| MRPS7 | -4528 | 1415 |
| MRPS9 | -752 | 7560 |
| MTFMT | -90 | 3569 |
| MTIF2 | 3537 | 5667 |
| MTIF3 | 4044 | 2054 |
| MTRF1L | 3729 | 2552 |
| N6AMT1 | -1220 | 326 |
| NARS2 | -1042 | 4530 |
| OXA1L | -1477 | 3023 |
| PABPC1 | 1884 | 3737 |
| PARS2 | 17 | 742 |
| PPA1 | 1609 | 5 |
| PPA2 | 2626 | 5436 |
| PTCD3 | 2243 | 1343 |
| RARS2 | 3992 | 315 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPN1 | -1640 | 6578 |
| RPN2 | 596 | 3798 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SARS2 | -4208 | 2722 |
| SEC11A | -824 | 6712 |
| SEC11C | 2870 | 5343 |
| SEC61A1 | -446 | 5888 |
| SEC61A2 | 2578 | 6659 |
| SEC61B | -4340 | 456 |
| SEC61G | 2509 | 2870 |
| SPCS2 | 2462 | 7887 |
| SPCS3 | 3891 | 4022 |
| SRP14 | 188 | 5822 |
| SRP19 | 4317 | 1191 |
| SRP54 | 4410 | 3638 |
| SRP68 | -571 | 267 |
| SRP72 | 1990 | 2265 |
| SRPRB | 931 | 2077 |
| SSR1 | 1746 | 94 |
| SSR2 | -3127 | 1250 |
| SSR3 | 2437 | 21 |
| TARS2 | 4119 | 2423 |
| TRAM1 | 3449 | 636 |
| TRMT112 | -4628 | 7797 |
| TSFM | -2654 | 5010 |
| TUFM | -4324 | 1422 |
| UBA52 | -4418 | 4404 |
| VARS2 | -827 | 2873 |
| WARS2 | 2449 | -77 |
| YARS2 | 324 | 4118 |
Influenza Viral RNA Transcription and Replication
| metric | value |
|---|---|
| setSize | 110 |
| pMANOVA | 1.1e-20 |
| p.adjustMANOVA | 6.85e-19 |
| s.dist | 0.527 |
| s.RNA | -0.527 |
| s.meth | -0.0307 |
| p.RNA | 1.56e-21 |
| p.meth | 0.58 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| DNAJC3 | 3023 | 8319 |
| FAU | -4597 | 5991 |
| GRSF1 | 865 | 1474 |
| GTF2F1 | -3508 | 1349 |
| GTF2F2 | 880 | 4275 |
| HSP90AA1 | 2643 | 4876 |
| IPO5 | -1368 | 8363 |
| NDC1 | 131 | -274 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| PARP1 | -3259 | 377 |
| POLR2A | 69 | -175 |
| POLR2B | 704 | 1497 |
| POLR2C | -3573 | 4506 |
| POLR2D | 1768 | 1352 |
| POLR2E | -4269 | 2995 |
| POLR2F | -4459 | 6542 |
| POLR2G | -4291 | 8051 |
| POLR2H | -4045 | 7582 |
| POLR2I | -4354 | 6360 |
| POLR2K | 2165 | 2463 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| RAE1 | -413 | 710 |
| RANBP2 | 3159 | 4436 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| TPR | 3600 | 5135 |
| UBA52 | -4418 | 4404 |
Regulation of expression of SLITs and ROBOs
| metric | value |
|---|---|
| setSize | 122 |
| pMANOVA | 3.08e-19 |
| p.adjustMANOVA | 1.82e-17 |
| s.dist | 0.482 |
| s.RNA | -0.479 |
| s.meth | -0.0496 |
| p.RNA | 7.22e-20 |
| p.meth | 0.346 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| CASC3 | -2347 | 3341 |
| CUL2 | 3543 | 6010 |
| DAG1 | -899 | 2764 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| ETF1 | 2978 | 7120 |
| FAU | -4597 | 5991 |
| GSPT1 | 3544 | 4369 |
| LDB1 | -4282 | 4806 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| PABPC1 | 1884 | 3737 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| RBX1 | 837 | 6226 |
| RNPS1 | -2236 | 2194 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SLIT1 | -2335 | 4573 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
| USP33 | 4320 | -215 |
| ZSWIM8 | -2563 | 4681 |
rRNA processing
| metric | value |
|---|---|
| setSize | 159 |
| pMANOVA | 5.58e-18 |
| p.adjustMANOVA | 3.14e-16 |
| s.dist | 0.407 |
| s.RNA | -0.403 |
| s.meth | -0.0615 |
| p.RNA | 2.47e-18 |
| p.meth | 0.183 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| SNU13 | -4216 | -644 |
| RPS23 | -4487 | -355 |
| NOP14 | -2020 | -739 |
| RPS8 | -4077 | -349 |
| EXOSC2 | -3220 | -380 |
| RRP9 | -4264 | -254 |
| NOB1 | -3642 | -264 |
| RPL36 | -4617 | -158 |
| FBL | -4641 | -91 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| BMS1 | -1396 | 282 |
| BYSL | -4246 | 5920 |
| C1D | 4019 | 3664 |
| CSNK1D | -3971 | 6586 |
| CSNK1E | -3456 | 7038 |
| DCAF13 | -705 | 1417 |
| DDX21 | 3996 | 7489 |
| DDX47 | 1480 | 899 |
| DDX49 | -3784 | 3923 |
| DDX52 | 4642 | 3608 |
| DHX37 | -2301 | 6256 |
| DIS3 | 4383 | 4903 |
| EBNA1BP2 | -2353 | 1408 |
| ELAC2 | -2787 | 5479 |
| ERI1 | 4502 | -203 |
| EXOSC1 | 1694 | 7262 |
| EXOSC10 | 2058 | 1784 |
| EXOSC2 | -3220 | -380 |
| EXOSC3 | 791 | 4976 |
| EXOSC4 | -3235 | 5215 |
| EXOSC5 | -3924 | 472 |
| EXOSC6 | -29 | 3480 |
| EXOSC7 | -4477 | 4110 |
| EXOSC8 | 1227 | 5376 |
| FAU | -4597 | 5991 |
| FBL | -4641 | -91 |
| FCF1 | 1672 | 5745 |
| FTSJ3 | 81 | 4982 |
| GAR1 | -1241 | 3773 |
| GNL3 | 743 | 1860 |
| HEATR1 | 972 | 6383 |
| IMP3 | -3902 | 6106 |
| IMP4 | -4106 | 4273 |
| ISG20L2 | 1909 | 2767 |
| KRR1 | 2512 | -810 |
| LTV1 | 887 | 2910 |
| MPHOSPH10 | 4283 | 5469 |
| MPHOSPH6 | 1514 | 6242 |
| MRM1 | -3796 | 2116 |
| MTERF4 | -3319 | 5833 |
| NCL | -2485 | 6814 |
| NHP2 | -4201 | 6994 |
| NIP7 | 727 | 5750 |
| NOB1 | -3642 | -264 |
| NOC4L | 1027 | 5529 |
| NOL11 | 1529 | -392 |
| NOL12 | -2859 | 6019 |
| NOL6 | -2343 | 6101 |
| NOL9 | 3048 | -796 |
| NOP10 | -3662 | 2404 |
| NOP14 | -2020 | -739 |
| NOP2 | -3857 | 5056 |
| NOP56 | -1965 | 117 |
| NOP58 | 3009 | 2119 |
| NSUN4 | 3419 | 782 |
| PDCD11 | -2458 | 1980 |
| PELP1 | -1762 | 6681 |
| PES1 | -4180 | 225 |
| PNO1 | 3733 | 1463 |
| PWP2 | -1048 | 3413 |
| RBM28 | -26 | 5611 |
| RCL1 | -2105 | 7180 |
| RIOK1 | 560 | 7832 |
| RIOK2 | 3774 | 1639 |
| RIOK3 | 4416 | 2142 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPP14 | 2365 | 6104 |
| RPP21 | -4132 | 6725 |
| RPP25 | -2129 | 7163 |
| RPP30 | 2696 | 4955 |
| RPP38 | 1524 | 1315 |
| RPP40 | 1358 | 2947 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRP1 | 1700 | 4263 |
| RRP7A | -1919 | 3257 |
| RRP9 | -4264 | -254 |
| SENP3 | -1607 | 8082 |
| SNU13 | -4216 | -644 |
| TBL3 | -3391 | 5281 |
| TEX10 | 3906 | -299 |
| TFB1M | 1711 | 2155 |
| THUMPD1 | 2892 | 1438 |
| TRMT112 | -4628 | 7797 |
| TSR1 | 936 | 6427 |
| TSR3 | -4599 | 1632 |
| UBA52 | -4418 | 4404 |
| UTP15 | 3847 | 2200 |
| UTP18 | 270 | 4533 |
| UTP20 | 2920 | 5003 |
| UTP3 | -2389 | 5911 |
| UTP6 | 2274 | 1898 |
| WDR12 | 2057 | 2290 |
| WDR18 | -2633 | 2126 |
| WDR3 | -412 | 553 |
| WDR36 | 2054 | 4917 |
| WDR43 | -603 | 2132 |
| WDR75 | 2858 | 3723 |
| XRN2 | 248 | 2920 |
rRNA processing in the nucleus and cytosol
| metric | value |
|---|---|
| setSize | 154 |
| pMANOVA | 6.43e-18 |
| p.adjustMANOVA | 3.44e-16 |
| s.dist | 0.413 |
| s.RNA | -0.409 |
| s.meth | -0.0598 |
| p.RNA | 2.57e-18 |
| p.meth | 0.203 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| SNU13 | -4216 | -644 |
| RPS23 | -4487 | -355 |
| NOP14 | -2020 | -739 |
| RPS8 | -4077 | -349 |
| EXOSC2 | -3220 | -380 |
| RRP9 | -4264 | -254 |
| NOB1 | -3642 | -264 |
| RPL36 | -4617 | -158 |
| FBL | -4641 | -91 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| BMS1 | -1396 | 282 |
| BYSL | -4246 | 5920 |
| C1D | 4019 | 3664 |
| CSNK1D | -3971 | 6586 |
| CSNK1E | -3456 | 7038 |
| DCAF13 | -705 | 1417 |
| DDX21 | 3996 | 7489 |
| DDX47 | 1480 | 899 |
| DDX49 | -3784 | 3923 |
| DDX52 | 4642 | 3608 |
| DHX37 | -2301 | 6256 |
| DIS3 | 4383 | 4903 |
| EBNA1BP2 | -2353 | 1408 |
| ERI1 | 4502 | -203 |
| EXOSC1 | 1694 | 7262 |
| EXOSC10 | 2058 | 1784 |
| EXOSC2 | -3220 | -380 |
| EXOSC3 | 791 | 4976 |
| EXOSC4 | -3235 | 5215 |
| EXOSC5 | -3924 | 472 |
| EXOSC6 | -29 | 3480 |
| EXOSC7 | -4477 | 4110 |
| EXOSC8 | 1227 | 5376 |
| FAU | -4597 | 5991 |
| FBL | -4641 | -91 |
| FCF1 | 1672 | 5745 |
| FTSJ3 | 81 | 4982 |
| GAR1 | -1241 | 3773 |
| GNL3 | 743 | 1860 |
| HEATR1 | 972 | 6383 |
| IMP3 | -3902 | 6106 |
| IMP4 | -4106 | 4273 |
| ISG20L2 | 1909 | 2767 |
| KRR1 | 2512 | -810 |
| LTV1 | 887 | 2910 |
| MPHOSPH10 | 4283 | 5469 |
| MPHOSPH6 | 1514 | 6242 |
| NCL | -2485 | 6814 |
| NHP2 | -4201 | 6994 |
| NIP7 | 727 | 5750 |
| NOB1 | -3642 | -264 |
| NOC4L | 1027 | 5529 |
| NOL11 | 1529 | -392 |
| NOL12 | -2859 | 6019 |
| NOL6 | -2343 | 6101 |
| NOL9 | 3048 | -796 |
| NOP10 | -3662 | 2404 |
| NOP14 | -2020 | -739 |
| NOP2 | -3857 | 5056 |
| NOP56 | -1965 | 117 |
| NOP58 | 3009 | 2119 |
| PDCD11 | -2458 | 1980 |
| PELP1 | -1762 | 6681 |
| PES1 | -4180 | 225 |
| PNO1 | 3733 | 1463 |
| PWP2 | -1048 | 3413 |
| RBM28 | -26 | 5611 |
| RCL1 | -2105 | 7180 |
| RIOK1 | 560 | 7832 |
| RIOK2 | 3774 | 1639 |
| RIOK3 | 4416 | 2142 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPP14 | 2365 | 6104 |
| RPP21 | -4132 | 6725 |
| RPP25 | -2129 | 7163 |
| RPP30 | 2696 | 4955 |
| RPP38 | 1524 | 1315 |
| RPP40 | 1358 | 2947 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRP1 | 1700 | 4263 |
| RRP7A | -1919 | 3257 |
| RRP9 | -4264 | -254 |
| SENP3 | -1607 | 8082 |
| SNU13 | -4216 | -644 |
| TBL3 | -3391 | 5281 |
| TEX10 | 3906 | -299 |
| THUMPD1 | 2892 | 1438 |
| TRMT112 | -4628 | 7797 |
| TSR1 | 936 | 6427 |
| TSR3 | -4599 | 1632 |
| UBA52 | -4418 | 4404 |
| UTP15 | 3847 | 2200 |
| UTP18 | 270 | 4533 |
| UTP20 | 2920 | 5003 |
| UTP3 | -2389 | 5911 |
| UTP6 | 2274 | 1898 |
| WDR12 | 2057 | 2290 |
| WDR18 | -2633 | 2126 |
| WDR3 | -412 | 553 |
| WDR36 | 2054 | 4917 |
| WDR43 | -603 | 2132 |
| WDR75 | 2858 | 3723 |
| XRN2 | 248 | 2920 |
Major pathway of rRNA processing in the nucleolus and cytosol
| metric | value |
|---|---|
| setSize | 147 |
| pMANOVA | 1.59e-16 |
| p.adjustMANOVA | 8.12e-15 |
| s.dist | 0.405 |
| s.RNA | -0.399 |
| s.meth | -0.0664 |
| p.RNA | 7.77e-17 |
| p.meth | 0.167 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| SNU13 | -4216 | -644 |
| RPS23 | -4487 | -355 |
| NOP14 | -2020 | -739 |
| RPS8 | -4077 | -349 |
| EXOSC2 | -3220 | -380 |
| RRP9 | -4264 | -254 |
| NOB1 | -3642 | -264 |
| RPL36 | -4617 | -158 |
| FBL | -4641 | -91 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| BMS1 | -1396 | 282 |
| BYSL | -4246 | 5920 |
| C1D | 4019 | 3664 |
| CSNK1D | -3971 | 6586 |
| CSNK1E | -3456 | 7038 |
| DCAF13 | -705 | 1417 |
| DDX21 | 3996 | 7489 |
| DDX47 | 1480 | 899 |
| DDX49 | -3784 | 3923 |
| DDX52 | 4642 | 3608 |
| DHX37 | -2301 | 6256 |
| DIS3 | 4383 | 4903 |
| EBNA1BP2 | -2353 | 1408 |
| ERI1 | 4502 | -203 |
| EXOSC1 | 1694 | 7262 |
| EXOSC10 | 2058 | 1784 |
| EXOSC2 | -3220 | -380 |
| EXOSC3 | 791 | 4976 |
| EXOSC4 | -3235 | 5215 |
| EXOSC5 | -3924 | 472 |
| EXOSC6 | -29 | 3480 |
| EXOSC7 | -4477 | 4110 |
| EXOSC8 | 1227 | 5376 |
| FAU | -4597 | 5991 |
| FBL | -4641 | -91 |
| FCF1 | 1672 | 5745 |
| FTSJ3 | 81 | 4982 |
| GNL3 | 743 | 1860 |
| HEATR1 | 972 | 6383 |
| IMP3 | -3902 | 6106 |
| IMP4 | -4106 | 4273 |
| ISG20L2 | 1909 | 2767 |
| KRR1 | 2512 | -810 |
| LTV1 | 887 | 2910 |
| MPHOSPH10 | 4283 | 5469 |
| MPHOSPH6 | 1514 | 6242 |
| NCL | -2485 | 6814 |
| NIP7 | 727 | 5750 |
| NOB1 | -3642 | -264 |
| NOC4L | 1027 | 5529 |
| NOL11 | 1529 | -392 |
| NOL12 | -2859 | 6019 |
| NOL6 | -2343 | 6101 |
| NOL9 | 3048 | -796 |
| NOP14 | -2020 | -739 |
| NOP56 | -1965 | 117 |
| NOP58 | 3009 | 2119 |
| PDCD11 | -2458 | 1980 |
| PELP1 | -1762 | 6681 |
| PES1 | -4180 | 225 |
| PNO1 | 3733 | 1463 |
| PWP2 | -1048 | 3413 |
| RBM28 | -26 | 5611 |
| RCL1 | -2105 | 7180 |
| RIOK1 | 560 | 7832 |
| RIOK2 | 3774 | 1639 |
| RIOK3 | 4416 | 2142 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPP14 | 2365 | 6104 |
| RPP21 | -4132 | 6725 |
| RPP25 | -2129 | 7163 |
| RPP30 | 2696 | 4955 |
| RPP38 | 1524 | 1315 |
| RPP40 | 1358 | 2947 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRP1 | 1700 | 4263 |
| RRP7A | -1919 | 3257 |
| RRP9 | -4264 | -254 |
| SENP3 | -1607 | 8082 |
| SNU13 | -4216 | -644 |
| TBL3 | -3391 | 5281 |
| TEX10 | 3906 | -299 |
| TSR1 | 936 | 6427 |
| UBA52 | -4418 | 4404 |
| UTP15 | 3847 | 2200 |
| UTP18 | 270 | 4533 |
| UTP20 | 2920 | 5003 |
| UTP3 | -2389 | 5911 |
| UTP6 | 2274 | 1898 |
| WDR12 | 2057 | 2290 |
| WDR18 | -2633 | 2126 |
| WDR3 | -412 | 553 |
| WDR36 | 2054 | 4917 |
| WDR43 | -603 | 2132 |
| WDR75 | 2858 | 3723 |
| XRN2 | 248 | 2920 |
Influenza Infection
| metric | value |
|---|---|
| setSize | 128 |
| pMANOVA | 4.2e-15 |
| p.adjustMANOVA | 2.05e-13 |
| s.dist | 0.415 |
| s.RNA | -0.414 |
| s.meth | -0.0289 |
| p.RNA | 6.58e-16 |
| p.meth | 0.574 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| CALR | 1654 | 3555 |
| CANX | 1496 | 7355 |
| CLTA | -1596 | 1476 |
| CLTC | 355 | 2682 |
| CPSF4 | -3066 | 7194 |
| DNAJC3 | 3023 | 8319 |
| EIF2AK2 | 4648 | 189 |
| FAU | -4597 | 5991 |
| GRSF1 | 865 | 1474 |
| GTF2F1 | -3508 | 1349 |
| GTF2F2 | 880 | 4275 |
| HSP90AA1 | 2643 | 4876 |
| HSPA1A | -2393 | 1113 |
| IPO5 | -1368 | 8363 |
| ISG15 | 4539 | -542 |
| KPNA1 | 2627 | 6172 |
| KPNA2 | 3157 | 843 |
| KPNA3 | 3283 | 1404 |
| KPNA4 | 3489 | 8152 |
| KPNA5 | 4177 | 1689 |
| KPNB1 | 3511 | 5921 |
| NDC1 | 131 | -274 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| PABPN1 | -2788 | 7278 |
| PARP1 | -3259 | 377 |
| POLR2A | 69 | -175 |
| POLR2B | 704 | 1497 |
| POLR2C | -3573 | 4506 |
| POLR2D | 1768 | 1352 |
| POLR2E | -4269 | 2995 |
| POLR2F | -4459 | 6542 |
| POLR2G | -4291 | 8051 |
| POLR2H | -4045 | 7582 |
| POLR2I | -4354 | 6360 |
| POLR2K | 2165 | 2463 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| RAE1 | -413 | 710 |
| RAN | -1758 | 2287 |
| RANBP2 | 3159 | 4436 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| TGFB1 | -2920 | 4353 |
| TPR | 3600 | 5135 |
| UBA52 | -4418 | 4404 |
| XPO1 | 4316 | 5628 |
Signaling by ROBO receptors
| metric | value |
|---|---|
| setSize | 153 |
| pMANOVA | 2.25e-14 |
| p.adjustMANOVA | 1.05e-12 |
| s.dist | 0.371 |
| s.RNA | -0.371 |
| s.meth | -0.0165 |
| p.RNA | 2.97e-15 |
| p.meth | 0.727 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ABL1 | -2415 | 5977 |
| ABL2 | -629 | 4991 |
| ARHGAP39 | -1168 | 8415 |
| CAP1 | -498 | 5579 |
| CASC3 | -2347 | 3341 |
| CDC42 | 3092 | 7063 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CUL2 | 3543 | 6010 |
| CXCR4 | -1226 | 6685 |
| DAG1 | -899 | 2764 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| ETF1 | 2978 | 7120 |
| EVL | -2192 | 3804 |
| FAU | -4597 | 5991 |
| GSPT1 | 3544 | 4369 |
| LDB1 | -4282 | 4806 |
| MYO9B | -344 | 3151 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| NCK1 | 76 | 1103 |
| NCK2 | -3976 | 2464 |
| NTN1 | -2541 | 8233 |
| PABPC1 | 1884 | 3737 |
| PAK1 | 3662 | 4972 |
| PAK2 | 2849 | 2509 |
| PAK4 | -2690 | 779 |
| PFN1 | -3621 | 2497 |
| PFN2 | -1216 | 8232 |
| PPP3CB | 3219 | 5276 |
| PRKACA | -456 | 3985 |
| PRKACB | -591 | 7740 |
| PRKAR2A | 717 | 532 |
| PRKCA | -1818 | 8000 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| RAC1 | 3104 | 7511 |
| RBX1 | 837 | 6226 |
| RHOA | 2017 | 1886 |
| RNPS1 | -2236 | 2194 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SLIT1 | -2335 | 4573 |
| SOS1 | 4239 | 3280 |
| SOS2 | 2856 | 87 |
| SRC | 831 | -92 |
| SRGAP1 | 4412 | 7388 |
| SRGAP3 | 3962 | 2145 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
| USP33 | 4320 | -215 |
| VASP | -1749 | 3426 |
| ZSWIM8 | -2563 | 4681 |
Formation of the ternary complex, and subsequently, the 43S complex
| metric | value |
|---|---|
| setSize | 40 |
| pMANOVA | 1.96e-11 |
| p.adjustMANOVA | 8.81e-10 |
| s.dist | 0.635 |
| s.RNA | -0.626 |
| s.meth | -0.109 |
| p.RNA | 7.36e-12 |
| p.meth | 0.233 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| FAU | -4597 | 5991 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
Metabolism of amino acids and derivatives
| metric | value |
|---|---|
| setSize | 219 |
| pMANOVA | 5.69e-11 |
| p.adjustMANOVA | 2.46e-09 |
| s.dist | 0.268 |
| s.RNA | -0.265 |
| s.meth | -0.0416 |
| p.RNA | 1.76e-11 |
| p.meth | 0.292 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| TST | -3953 | -727 |
| PAOX | -3058 | -784 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| IL4I1 | -1529 | -346 |
| BCKDK | -1667 | -102 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AANAT | 1895 | 7396 |
| ACADSB | 1775 | 8307 |
| ACAT1 | 2452 | 5751 |
| ADO | -1163 | 6026 |
| AFMID | 4331 | 1182 |
| AGMAT | 960 | 113 |
| AHCY | -4193 | 1896 |
| AIMP2 | 1455 | 6011 |
| ALDH18A1 | -2728 | 6062 |
| ALDH4A1 | -2260 | 3158 |
| ALDH6A1 | 636 | 335 |
| ALDH9A1 | 365 | 6692 |
| AMD1 | 3119 | 1679 |
| AMDHD1 | -1225 | 7850 |
| ARG2 | 1997 | 5936 |
| ASL | -813 | 7724 |
| ASNS | 1581 | 2242 |
| ASRGL1 | -1586 | 4268 |
| AUH | 806 | 1233 |
| AZIN1 | 1196 | 202 |
| AZIN2 | -1536 | 711 |
| BCAT1 | 2568 | 3114 |
| BCAT2 | -2441 | 2278 |
| BCKDHA | -3673 | 3276 |
| BCKDHB | 3030 | 1441 |
| BCKDK | -1667 | -102 |
| CARNMT1 | 1664 | 1640 |
| CARNS1 | 888 | 4453 |
| CKB | 393 | 6935 |
| CPS1 | 2640 | -256 |
| CRYM | -1784 | 4980 |
| CSAD | 1599 | 3086 |
| CTH | 2789 | 1184 |
| DBT | 4481 | 1175 |
| DHTKD1 | 4041 | 4620 |
| DLAT | 771 | 1054 |
| DLD | 3181 | 4527 |
| DLST | -3324 | 7228 |
| ECHS1 | -2544 | 4579 |
| EEF1E1 | -132 | 3266 |
| EEFSEC | -1276 | 6233 |
| ENOPH1 | -3863 | 4057 |
| ETHE1 | -4327 | 804 |
| FAH | -1191 | 526 |
| FAU | -4597 | 5991 |
| GCDH | -4665 | 937 |
| GCSH | 567 | 8071 |
| GLS | 3017 | 572 |
| GLUD1 | 366 | 5206 |
| GLUL | 431 | 7319 |
| GOT1 | 1359 | 4943 |
| GOT2 | -1694 | 1040 |
| GPT2 | -744 | 6335 |
| GRHPR | -1777 | 1385 |
| GSR | -1273 | 1990 |
| GSTZ1 | 2504 | 2248 |
| HIBADH | 1941 | -309 |
| HIBCH | 3702 | 7161 |
| HPD | 4553 | 4383 |
| IL4I1 | -1529 | -346 |
| IVD | -560 | 963 |
| KMO | 2492 | 2433 |
| LIAS | 3516 | 6063 |
| LIPT1 | 3406 | 7533 |
| LIPT2 | -2872 | 5908 |
| MCCC1 | 399 | 8183 |
| MCCC2 | 4355 | 5255 |
| MPST | -4160 | 6640 |
| MTAP | 1351 | 8057 |
| MTR | 1193 | 3011 |
| MTRR | 2720 | 5670 |
| NAGS | -4298 | 5040 |
| NDUFAB1 | -2963 | 1043 |
| NMRAL1 | -2809 | 6966 |
| NQO1 | -2719 | 4198 |
| OAT | 2059 | 329 |
| OAZ1 | -3109 | 6795 |
| OAZ2 | -681 | 7617 |
| OAZ3 | 402 | 3936 |
| ODC1 | 576 | 6387 |
| OGDH | 106 | 1499 |
| PAOX | -3058 | -784 |
| PAPSS1 | 1440 | 6222 |
| PCBD1 | -701 | 8417 |
| PDHB | 1458 | 6538 |
| PDHX | 998 | 5278 |
| PHGDH | 1399 | 6806 |
| PHYKPL | 1656 | -693 |
| PPM1K | 4474 | 3255 |
| PSAT1 | 3574 | 3577 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PSPH | 634 | 5960 |
| PSTK | 687 | 7792 |
| PXMP2 | -1249 | 1966 |
| PYCR2 | -4652 | 1819 |
| QDPR | 3288 | 154 |
| RIMKLB | -1456 | 7026 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| SARDH | -3617 | 8313 |
| SCLY | -1972 | 681 |
| SEPHS2 | -3131 | 4134 |
| SERINC1 | 2382 | 307 |
| SERINC3 | 554 | 2970 |
| SERINC4 | 2341 | -52 |
| SERINC5 | -1307 | 3136 |
| SHMT1 | 1176 | 4297 |
| SLC25A12 | 893 | 2412 |
| SLC25A13 | 1243 | 7294 |
| SLC25A15 | -2437 | 1269 |
| SLC25A44 | 945 | 5950 |
| SLC36A4 | 3940 | 1392 |
| SLC3A2 | -2240 | 497 |
| SLC44A1 | 1642 | 3793 |
| SLC5A5 | 868 | 1265 |
| SLC7A5 | 846 | -652 |
| SRM | -3117 | 3333 |
| TST | -3953 | -727 |
| TSTD1 | -3692 | 8445 |
| TXN2 | -4066 | 5130 |
| TXNRD1 | -851 | 214 |
| UBA52 | -4418 | 4404 |
Axon guidance
| metric | value |
|---|---|
| setSize | 295 |
| pMANOVA | 1.02e-10 |
| p.adjustMANOVA | 4.25e-09 |
| s.dist | 0.23 |
| s.RNA | -0.229 |
| s.meth | -0.0227 |
| p.RNA | 1.98e-11 |
| p.meth | 0.506 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| MAPK3 | -4654 | -479 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| DOK2 | -2274 | -569 |
| LIMK1 | -1621 | -632 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| GIT1 | -4150 | -130 |
| SEMA3A | -623 | -798 |
| CNTNAP1 | -721 | -564 |
| RPS6KA4 | -2770 | -121 |
| MAP2K1 | -710 | -148 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ABL1 | -2415 | 5977 |
| ABL2 | -629 | 4991 |
| ABLIM1 | -2783 | 4445 |
| ABLIM2 | -2867 | 7101 |
| ACTB | -398 | 4265 |
| ACTG1 | -3749 | 6428 |
| ACTR2 | 3409 | 4951 |
| ACTR3 | 1752 | 4499 |
| ADAM10 | 2774 | 3603 |
| AGAP2 | -3788 | 1611 |
| AGRN | 3968 | 3516 |
| ALCAM | -2738 | 465 |
| ANK1 | 185 | 253 |
| ANK3 | 1141 | -855 |
| AP2A1 | 143 | 1895 |
| AP2M1 | -4214 | 5734 |
| AP2S1 | -2753 | 3997 |
| APH1A | -4123 | 1663 |
| APH1B | 3961 | 2594 |
| ARHGAP35 | -3569 | 6432 |
| ARHGAP39 | -1168 | 8415 |
| ARHGEF12 | -421 | 8154 |
| ARHGEF7 | -2793 | 964 |
| ARPC1B | -2892 | 2843 |
| ARPC2 | 469 | 5703 |
| ARPC3 | 2190 | 4838 |
| ARPC5 | 2839 | 2343 |
| CACNA1C | -3748 | 3128 |
| CACNA1I | -1347 | 683 |
| CACNB3 | -1466 | 4217 |
| CAP1 | -498 | 5579 |
| CASC3 | -2347 | 3341 |
| CD72 | -4442 | 1306 |
| CDC42 | 3092 | 7063 |
| CDK5 | 767 | 4651 |
| CDK5R1 | -3813 | 7721 |
| CFL1 | -3122 | 4075 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CLTA | -1596 | 1476 |
| CLTB | -4279 | 600 |
| CLTC | 355 | 2682 |
| CLTCL1 | -18 | 7791 |
| CNTNAP1 | -721 | -564 |
| COL9A2 | 3330 | 1721 |
| CREB1 | 2778 | 5066 |
| CSNK2A2 | 1848 | 3957 |
| CSNK2B | -56 | 7503 |
| CUL2 | 3543 | 6010 |
| CXCR4 | -1226 | 6685 |
| DAG1 | -899 | 2764 |
| DLG1 | 3070 | 5149 |
| DLG4 | -884 | 284 |
| DNM1 | 4341 | 2162 |
| DNM2 | -3538 | 6605 |
| DOK2 | -2274 | -569 |
| DOK4 | -4497 | 6128 |
| DPYSL2 | 3115 | 7422 |
| EFNA3 | -2140 | 7466 |
| EFNA4 | -1649 | 7073 |
| EFNB2 | -2982 | 8212 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| EPHA4 | -4265 | 6667 |
| EPHB6 | -4453 | 1026 |
| ERBB2 | -1287 | 7893 |
| ETF1 | 2978 | 7120 |
| EVL | -2192 | 3804 |
| EZR | 1057 | 5759 |
| FARP2 | 1855 | 1865 |
| FAU | -4597 | 5991 |
| FES | -2861 | 4123 |
| FRS2 | 2770 | 165 |
| FYN | -1416 | 2811 |
| GAB2 | 239 | 350 |
| GIT1 | -4150 | -130 |
| GRB10 | 1083 | 192 |
| GRB2 | -584 | 5992 |
| GRIN1 | -2758 | 6304 |
| GSK3B | -53 | 3637 |
| GSPT1 | 3544 | 4369 |
| HRAS | -3828 | 1490 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| IRS2 | -769 | 5305 |
| ITGA1 | 129 | 5574 |
| ITGA2 | 4549 | 4016 |
| ITGA5 | -3016 | 6926 |
| ITGAV | 2346 | 3287 |
| ITSN1 | 4322 | 5424 |
| KRAS | 4217 | 4020 |
| LDB1 | -4282 | 4806 |
| LIMK1 | -1621 | -632 |
| LIMK2 | -1657 | 4617 |
| LYPLA2 | -4333 | 2325 |
| MAP2K1 | -710 | -148 |
| MAP2K2 | -4596 | 8056 |
| MAPK1 | 300 | 2770 |
| MAPK14 | 586 | 2235 |
| MAPK3 | -4654 | -479 |
| MAPK7 | -556 | 3019 |
| MAPK8 | 1601 | 6176 |
| MYH10 | 2140 | 3825 |
| MYH9 | -2293 | 3393 |
| MYL12A | -320 | 3613 |
| MYL6 | -4267 | 4209 |
| MYO9B | -344 | 3151 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| NCK1 | 76 | 1103 |
| NCK2 | -3976 | 2464 |
| NCSTN | 1936 | -457 |
| NEO1 | -3704 | 949 |
| NTN1 | -2541 | 8233 |
| NUMB | 2288 | 1647 |
| PABPC1 | 1884 | 3737 |
| PAK1 | 3662 | 4972 |
| PAK2 | 2849 | 2509 |
| PAK4 | -2690 | 779 |
| PDLIM7 | -472 | 142 |
| PFN1 | -3621 | 2497 |
| PFN2 | -1216 | 8232 |
| PIK3CA | 2762 | 3290 |
| PIK3CD | -3743 | 153 |
| PIK3R1 | -1510 | 5157 |
| PIK3R2 | -2818 | 5365 |
| PIK3R3 | 3211 | 3533 |
| PIP5K1C | -2340 | 8050 |
| PITPNA | 1756 | 1699 |
| PLCG1 | -1509 | 5809 |
| PLXNA2 | -1457 | 4087 |
| PLXNC1 | 2018 | 1218 |
| PLXND1 | -479 | 6377 |
| PPP3CB | 3219 | 5276 |
| PRKACA | -456 | 3985 |
| PRKACB | -591 | 7740 |
| PRKAR2A | 717 | 532 |
| PRKCA | -1818 | 8000 |
| PRKCQ | -1062 | 3938 |
| PRNP | 197 | 861 |
| PSEN1 | 3287 | 1724 |
| PSEN2 | 607 | 4736 |
| PSENEN | -1847 | 5332 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTK2 | 498 | 2498 |
| PTPN11 | 942 | 3777 |
| PTPRA | -2832 | 5280 |
| PTPRC | 3675 | 1766 |
| RAC1 | 3104 | 7511 |
| RANBP9 | 94 | 4150 |
| RASA1 | 4236 | 3050 |
| RBX1 | 837 | 6226 |
| RHOA | 2017 | 1886 |
| RHOB | 2740 | 4751 |
| RND1 | 3392 | 344 |
| RNPS1 | -2236 | 2194 |
| ROCK1 | 4407 | 2216 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS6KA1 | -2059 | 6292 |
| RPS6KA2 | -1618 | 6457 |
| RPS6KA4 | -2770 | -121 |
| RPS6KA5 | 4395 | 7378 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRAS | 3221 | 4131 |
| SDCBP | 1371 | 7446 |
| SEMA3A | -623 | -798 |
| SEMA4A | 2008 | -775 |
| SEMA4D | -1 | 721 |
| SEMA7A | -1480 | 4968 |
| SHC1 | 2869 | 7320 |
| SIAH1 | 157 | 5770 |
| SIAH2 | 3459 | 1878 |
| SLIT1 | -2335 | 4573 |
| SOS1 | 4239 | 3280 |
| SOS2 | 2856 | 87 |
| SPTAN1 | -3370 | 372 |
| SPTBN1 | -3730 | 7757 |
| SPTBN5 | 191 | 2482 |
| SRC | 831 | -92 |
| SRGAP1 | 4412 | 7388 |
| SRGAP3 | 3962 | 2145 |
| ST8SIA4 | 3866 | 3040 |
| TLN1 | -2005 | 2103 |
| TRIO | -2384 | 8416 |
| TRPC1 | 2000 | 4764 |
| TYROBP | -1830 | 835 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
| USP33 | 4320 | -215 |
| VASP | -1749 | 3426 |
| VAV2 | 1189 | 7727 |
| VAV3 | -2987 | 8297 |
| WASL | 2271 | 7402 |
| YES1 | 842 | -624 |
| ZSWIM8 | -2563 | 4681 |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
| metric | value |
|---|---|
| setSize | 48 |
| pMANOVA | 2.23e-10 |
| p.adjustMANOVA | 8.95e-09 |
| s.dist | 0.552 |
| s.RNA | -0.547 |
| s.meth | -0.0751 |
| p.RNA | 5.69e-11 |
| p.meth | 0.369 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4EBP1 | -1795 | 3840 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| FAU | -4597 | 5991 |
| PABPC1 | 1884 | 3737 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
Translation initiation complex formation
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 2.64e-10 |
| p.adjustMANOVA | 9.93e-09 |
| s.dist | 0.556 |
| s.RNA | -0.55 |
| s.meth | -0.0769 |
| p.RNA | 6.87e-11 |
| p.meth | 0.363 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| FAU | -4597 | 5991 |
| PABPC1 | 1884 | 3737 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
Nervous system development
| metric | value |
|---|---|
| setSize | 307 |
| pMANOVA | 2.65e-10 |
| p.adjustMANOVA | 9.93e-09 |
| s.dist | 0.221 |
| s.RNA | -0.22 |
| s.meth | -0.0229 |
| p.RNA | 5.31e-11 |
| p.meth | 0.493 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| MAPK3 | -4654 | -479 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| DOK2 | -2274 | -569 |
| LIMK1 | -1621 | -632 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| GIT1 | -4150 | -130 |
| SEMA3A | -623 | -798 |
| CNTNAP1 | -721 | -564 |
| RPS6KA4 | -2770 | -121 |
| MAP2K1 | -710 | -148 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ABL1 | -2415 | 5977 |
| ABL2 | -629 | 4991 |
| ABLIM1 | -2783 | 4445 |
| ABLIM2 | -2867 | 7101 |
| ACTB | -398 | 4265 |
| ACTG1 | -3749 | 6428 |
| ACTR2 | 3409 | 4951 |
| ACTR3 | 1752 | 4499 |
| ADAM10 | 2774 | 3603 |
| AGAP2 | -3788 | 1611 |
| AGRN | 3968 | 3516 |
| ALCAM | -2738 | 465 |
| ANK1 | 185 | 253 |
| ANK3 | 1141 | -855 |
| AP2A1 | 143 | 1895 |
| AP2M1 | -4214 | 5734 |
| AP2S1 | -2753 | 3997 |
| APH1A | -4123 | 1663 |
| APH1B | 3961 | 2594 |
| ARHGAP35 | -3569 | 6432 |
| ARHGAP39 | -1168 | 8415 |
| ARHGEF12 | -421 | 8154 |
| ARHGEF7 | -2793 | 964 |
| ARPC1B | -2892 | 2843 |
| ARPC2 | 469 | 5703 |
| ARPC3 | 2190 | 4838 |
| ARPC5 | 2839 | 2343 |
| CACNA1C | -3748 | 3128 |
| CACNA1I | -1347 | 683 |
| CACNB3 | -1466 | 4217 |
| CAP1 | -498 | 5579 |
| CASC3 | -2347 | 3341 |
| CD72 | -4442 | 1306 |
| CDC42 | 3092 | 7063 |
| CDK5 | 767 | 4651 |
| CDK5R1 | -3813 | 7721 |
| CFL1 | -3122 | 4075 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CLTA | -1596 | 1476 |
| CLTB | -4279 | 600 |
| CLTC | 355 | 2682 |
| CLTCL1 | -18 | 7791 |
| CNTNAP1 | -721 | -564 |
| COL9A2 | 3330 | 1721 |
| CREB1 | 2778 | 5066 |
| CSNK2A2 | 1848 | 3957 |
| CSNK2B | -56 | 7503 |
| CUL2 | 3543 | 6010 |
| CXCR4 | -1226 | 6685 |
| CYP51A1 | 3722 | 2962 |
| DAG1 | -899 | 2764 |
| DLG1 | 3070 | 5149 |
| DLG4 | -884 | 284 |
| DNM1 | 4341 | 2162 |
| DNM2 | -3538 | 6605 |
| DOK2 | -2274 | -569 |
| DOK4 | -4497 | 6128 |
| DPYSL2 | 3115 | 7422 |
| EFNA3 | -2140 | 7466 |
| EFNA4 | -1649 | 7073 |
| EFNB2 | -2982 | 8212 |
| EGR2 | -521 | 5319 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| EPHA4 | -4265 | 6667 |
| EPHB6 | -4453 | 1026 |
| ERBB2 | -1287 | 7893 |
| ETF1 | 2978 | 7120 |
| EVL | -2192 | 3804 |
| EZR | 1057 | 5759 |
| FARP2 | 1855 | 1865 |
| FAU | -4597 | 5991 |
| FES | -2861 | 4123 |
| FRS2 | 2770 | 165 |
| FYN | -1416 | 2811 |
| GAB2 | 239 | 350 |
| GIT1 | -4150 | -130 |
| GRB10 | 1083 | 192 |
| GRB2 | -584 | 5992 |
| GRIN1 | -2758 | 6304 |
| GSK3B | -53 | 3637 |
| GSPT1 | 3544 | 4369 |
| HDAC2 | 196 | 4593 |
| HMGCR | 675 | 4936 |
| HRAS | -3828 | 1490 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| IRS2 | -769 | 5305 |
| ITGA1 | 129 | 5574 |
| ITGA2 | 4549 | 4016 |
| ITGA5 | -3016 | 6926 |
| ITGAV | 2346 | 3287 |
| ITSN1 | 4322 | 5424 |
| KRAS | 4217 | 4020 |
| LAMA2 | -1833 | 5768 |
| LDB1 | -4282 | 4806 |
| LIMK1 | -1621 | -632 |
| LIMK2 | -1657 | 4617 |
| LYPLA2 | -4333 | 2325 |
| MAP2K1 | -710 | -148 |
| MAP2K2 | -4596 | 8056 |
| MAPK1 | 300 | 2770 |
| MAPK14 | 586 | 2235 |
| MAPK3 | -4654 | -479 |
| MAPK7 | -556 | 3019 |
| MAPK8 | 1601 | 6176 |
| MBP | -2941 | 4049 |
| MPZ | -3160 | 5102 |
| MYH10 | 2140 | 3825 |
| MYH9 | -2293 | 3393 |
| MYL12A | -320 | 3613 |
| MYL6 | -4267 | 4209 |
| MYO9B | -344 | 3151 |
| NAB1 | 4437 | 1502 |
| NAB2 | 265 | 3007 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| NCK1 | 76 | 1103 |
| NCK2 | -3976 | 2464 |
| NCSTN | 1936 | -457 |
| NEO1 | -3704 | 949 |
| NTN1 | -2541 | 8233 |
| NUMB | 2288 | 1647 |
| PABPC1 | 1884 | 3737 |
| PAK1 | 3662 | 4972 |
| PAK2 | 2849 | 2509 |
| PAK4 | -2690 | 779 |
| PDLIM7 | -472 | 142 |
| PFN1 | -3621 | 2497 |
| PFN2 | -1216 | 8232 |
| PIK3CA | 2762 | 3290 |
| PIK3CD | -3743 | 153 |
| PIK3R1 | -1510 | 5157 |
| PIK3R2 | -2818 | 5365 |
| PIK3R3 | 3211 | 3533 |
| PIP5K1C | -2340 | 8050 |
| PITPNA | 1756 | 1699 |
| PLCG1 | -1509 | 5809 |
| PLXNA2 | -1457 | 4087 |
| PLXNC1 | 2018 | 1218 |
| PLXND1 | -479 | 6377 |
| PPP3CB | 3219 | 5276 |
| PRKACA | -456 | 3985 |
| PRKACB | -591 | 7740 |
| PRKAR2A | 717 | 532 |
| PRKCA | -1818 | 8000 |
| PRKCQ | -1062 | 3938 |
| PRNP | 197 | 861 |
| PSEN1 | 3287 | 1724 |
| PSEN2 | 607 | 4736 |
| PSENEN | -1847 | 5332 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTK2 | 498 | 2498 |
| PTPN11 | 942 | 3777 |
| PTPRA | -2832 | 5280 |
| PTPRC | 3675 | 1766 |
| RAC1 | 3104 | 7511 |
| RANBP9 | 94 | 4150 |
| RASA1 | 4236 | 3050 |
| RBX1 | 837 | 6226 |
| RHOA | 2017 | 1886 |
| RHOB | 2740 | 4751 |
| RND1 | 3392 | 344 |
| RNPS1 | -2236 | 2194 |
| ROCK1 | 4407 | 2216 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS6KA1 | -2059 | 6292 |
| RPS6KA2 | -1618 | 6457 |
| RPS6KA4 | -2770 | -121 |
| RPS6KA5 | 4395 | 7378 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRAS | 3221 | 4131 |
| SDCBP | 1371 | 7446 |
| SEMA3A | -623 | -798 |
| SEMA4A | 2008 | -775 |
| SEMA4D | -1 | 721 |
| SEMA7A | -1480 | 4968 |
| SHC1 | 2869 | 7320 |
| SIAH1 | 157 | 5770 |
| SIAH2 | 3459 | 1878 |
| SLIT1 | -2335 | 4573 |
| SMARCA4 | -2205 | 2893 |
| SOS1 | 4239 | 3280 |
| SOS2 | 2856 | 87 |
| SPTAN1 | -3370 | 372 |
| SPTBN1 | -3730 | 7757 |
| SPTBN5 | 191 | 2482 |
| SRC | 831 | -92 |
| SREBF2 | -396 | 3407 |
| SRGAP1 | 4412 | 7388 |
| SRGAP3 | 3962 | 2145 |
| ST8SIA4 | 3866 | 3040 |
| TLN1 | -2005 | 2103 |
| TRIO | -2384 | 8416 |
| TRPC1 | 2000 | 4764 |
| TYROBP | -1830 | 835 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
| USP33 | 4320 | -215 |
| UTRN | 2424 | 460 |
| VASP | -1749 | 3426 |
| VAV2 | 1189 | 7727 |
| VAV3 | -2987 | 8297 |
| WASL | 2271 | 7402 |
| YES1 | 842 | -624 |
| ZSWIM8 | -2563 | 4681 |
Cellular responses to stress
| metric | value |
|---|---|
| setSize | 392 |
| pMANOVA | 3.96e-10 |
| p.adjustMANOVA | 1.4e-08 |
| s.dist | 0.195 |
| s.RNA | -0.195 |
| s.meth | -0.00921 |
| p.RNA | 5.8e-11 |
| p.meth | 0.757 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| LAMTOR1 | -3908 | -649 |
| MAPK3 | -4654 | -479 |
| DCTN2 | -4181 | -467 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| AGO1 | -1699 | -803 |
| LAMTOR2 | -4436 | -288 |
| HIF1AN | -3821 | -320 |
| EHMT1 | -1867 | -506 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| NCF4 | -3378 | -141 |
| AJUBA | -567 | -835 |
| STIP1 | -3501 | -119 |
| TXNRD2 | -1851 | -152 |
| RPTOR | -727 | -222 |
| ATP6V0E2 | -1133 | -8 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ACD | -4048 | 3685 |
| ACTR10 | 2160 | 5133 |
| ACTR1A | -3110 | 886 |
| AGO1 | -1699 | -803 |
| AGO3 | 4554 | 8331 |
| AJUBA | -567 | -835 |
| AKT1S1 | -3490 | 5797 |
| ANAPC1 | -2044 | 3351 |
| ANAPC10 | 1009 | -306 |
| ANAPC11 | -4292 | 7059 |
| ANAPC15 | -4084 | 2693 |
| ANAPC16 | -1049 | 6873 |
| ANAPC2 | -3136 | 1387 |
| ANAPC4 | 4429 | 1495 |
| ANAPC5 | 908 | 3142 |
| ANAPC7 | 3490 | 869 |
| ARNT | 2384 | 5016 |
| ASNS | 1581 | 2242 |
| ATF3 | 4330 | 5006 |
| ATF4 | -1992 | 3847 |
| ATF5 | 2993 | 279 |
| ATM | 20 | 2443 |
| ATOX1 | -2570 | 8027 |
| ATP6V0B | -3239 | 4939 |
| ATP6V0C | 7 | 2508 |
| ATP6V0D1 | -1378 | 5821 |
| ATP6V0E1 | -2501 | 5554 |
| ATP6V0E2 | -1133 | -8 |
| ATP6V1A | 2373 | 3932 |
| ATP6V1B2 | 1474 | 2977 |
| ATP6V1C1 | 2649 | 3448 |
| ATP6V1D | 871 | 449 |
| ATP6V1E1 | 1207 | 6230 |
| ATP6V1F | -4025 | 2967 |
| ATP6V1G2 | 108 | 7771 |
| ATP6V1H | -994 | 5715 |
| ATR | 3357 | 3477 |
| BAG1 | 569 | 3503 |
| BAG2 | 1823 | 2917 |
| BAG3 | -2828 | 1533 |
| BAG4 | 2818 | 2195 |
| BAG5 | 671 | 5951 |
| BMI1 | 1215 | 4629 |
| C12orf66 | 2902 | 7834 |
| CABIN1 | -3524 | 3096 |
| CAMK2D | -1258 | 3808 |
| CAMK2G | -2604 | 31 |
| CAPZA1 | 3324 | 7829 |
| CAPZA2 | 3455 | 3750 |
| CAPZB | -1556 | 3064 |
| CAT | 1372 | -221 |
| CBX4 | -2808 | 5617 |
| CBX6 | -3228 | 7540 |
| CBX8 | -1650 | 73 |
| CCAR2 | -1306 | 1073 |
| CCNA2 | 1688 | 6920 |
| CCNE1 | 3783 | 6755 |
| CCNE2 | 1042 | 5076 |
| CCS | -4331 | 5087 |
| CDC16 | 1994 | 7052 |
| CDC23 | 1843 | 4397 |
| CDK2 | -1746 | 6577 |
| CDK4 | -4272 | 6700 |
| CDK6 | 3142 | 2094 |
| CDKN1A | 2610 | 7579 |
| CDKN1B | -1996 | 1658 |
| CDKN2A | 2101 | 4878 |
| CDKN2C | -3393 | 4213 |
| CDKN2D | -4602 | 5171 |
| CEBPB | 37 | 2587 |
| CEBPG | 2366 | 5011 |
| CITED2 | -93 | 6665 |
| CREBBP | -2371 | 6830 |
| CUL2 | 3543 | 6010 |
| CYBA | -2039 | 5379 |
| CYCS | 2507 | 2450 |
| DCTN2 | -4181 | -467 |
| DCTN3 | -3566 | 4086 |
| DCTN4 | 3602 | 3763 |
| DCTN5 | -1624 | 7654 |
| DCTN6 | 3077 | 6435 |
| DDIT3 | 1184 | 1641 |
| DEDD2 | -3321 | 2856 |
| DEPDC5 | 1787 | 1033 |
| DNAJA1 | 3185 | 5172 |
| DNAJA2 | 716 | 7945 |
| DNAJA4 | -731 | 2213 |
| DNAJB1 | -4240 | 5251 |
| DNAJB6 | -1165 | 7519 |
| DNAJC2 | 3874 | 421 |
| DYNC1H1 | -363 | 1172 |
| DYNC1I2 | 1771 | 261 |
| DYNC1LI1 | 3057 | 6081 |
| DYNC1LI2 | 2777 | 3137 |
| DYNLL1 | -2331 | 5391 |
| DYNLL2 | -3503 | 3308 |
| E2F1 | 2277 | 1130 |
| E2F2 | 1158 | 3021 |
| E2F3 | 3158 | 5634 |
| EED | 2485 | 2932 |
| EEF1A1 | -4296 | 2014 |
| EGLN1 | 779 | 5177 |
| EGLN2 | -4506 | 4388 |
| EHMT1 | -1867 | -506 |
| EHMT2 | -4004 | 5106 |
| EIF2AK1 | 1428 | 1917 |
| EIF2AK4 | -1627 | 6865 |
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EP300 | 1140 | 3364 |
| EP400 | -218 | 2028 |
| EPAS1 | 3726 | -699 |
| ERF | -4093 | 5827 |
| ERO1A | 4290 | -809 |
| ETS1 | -2992 | 4334 |
| ETS2 | -918 | 1436 |
| EZH2 | 4525 | 4485 |
| FAU | -4597 | 5991 |
| FKBP4 | -3165 | 4677 |
| FKBP5 | 4166 | 1867 |
| FLCN | 2232 | 2472 |
| FNIP1 | 3908 | 6015 |
| FOS | -3641 | 4083 |
| FZR1 | -2370 | 7430 |
| GCN1 | -1543 | 7280 |
| GPX1 | -4030 | 2183 |
| GRB10 | 1083 | 192 |
| GSK3B | -53 | 3637 |
| GSR | -1273 | 1990 |
| GSTP1 | -2214 | 6832 |
| HIF1A | 2136 | 4115 |
| HIF1AN | -3821 | -320 |
| HIGD1A | 2015 | 4139 |
| HIRA | -1304 | 6286 |
| HMGA1 | -4231 | 5560 |
| HSBP1 | 1933 | 1432 |
| HSF1 | -2309 | 5763 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| HSPA13 | 1170 | 4247 |
| HSPA14 | 4029 | 7441 |
| HSPA1A | -2393 | 1113 |
| HSPA1B | -808 | 755 |
| HSPA1L | -1936 | 336 |
| HSPA2 | -2606 | 5784 |
| HSPA4 | 1735 | 8237 |
| HSPA4L | 3658 | 7845 |
| HSPA9 | -476 | 5882 |
| HSPH1 | 2157 | 3890 |
| ID1 | -3700 | 5853 |
| ITFG2 | 1100 | 3363 |
| JUN | -3439 | 2775 |
| KAT5 | -2212 | 5607 |
| KDM6B | -1951 | 2846 |
| KPTN | -2646 | 7869 |
| LAMTOR1 | -3908 | -649 |
| LAMTOR2 | -4436 | -288 |
| LAMTOR3 | 2397 | 6767 |
| LAMTOR4 | -4065 | 1911 |
| LAMTOR5 | -3713 | 7083 |
| LIMD1 | 1448 | 2244 |
| LMNB1 | 4058 | 4104 |
| MAP2K3 | -1357 | 38 |
| MAP2K4 | 810 | 3168 |
| MAP2K6 | 2412 | 2172 |
| MAP2K7 | -3856 | 2099 |
| MAP3K5 | 2214 | 4831 |
| MAP4K4 | -447 | 7027 |
| MAPK1 | 300 | 2770 |
| MAPK14 | 586 | 2235 |
| MAPK3 | -4654 | -479 |
| MAPK7 | -556 | 3019 |
| MAPK8 | 1601 | 6176 |
| MAPK9 | -1494 | 1159 |
| MAPKAPK2 | -3294 | 1423 |
| MAPKAPK3 | 486 | 58 |
| MDM2 | 4628 | 1092 |
| MDM4 | 3853 | 1115 |
| MINK1 | -3455 | 2629 |
| MIOS | 1051 | 3553 |
| MLST8 | -3610 | 3421 |
| MOV10 | 4273 | 7640 |
| MRPL18 | -756 | 3878 |
| MTOR | -2622 | 1240 |
| NBN | 4170 | 1983 |
| NCF4 | -3378 | -141 |
| NDC1 | 131 | -274 |
| NPRL2 | -2764 | 5068 |
| NPRL3 | 408 | 7970 |
| NR3C1 | 1145 | 4250 |
| NR3C2 | -1917 | 6632 |
| NUDT2 | -1434 | 6673 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| P4HB | -3085 | 6831 |
| PHC1 | -4242 | 606 |
| PHC2 | -1130 | 4319 |
| PHC3 | 3313 | 522 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PPP1R15A | -3660 | 5649 |
| PRDX1 | 1742 | 4095 |
| PRDX2 | -2637 | 6462 |
| PRDX3 | 2541 | 3939 |
| PRDX5 | -4334 | 7719 |
| PRDX6 | -2233 | 4160 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTGES3 | 2915 | 2735 |
| RAD50 | 4602 | 179 |
| RAE1 | -413 | 710 |
| RANBP2 | 3159 | 4436 |
| RB1 | 3165 | 1518 |
| RBBP4 | 474 | 2574 |
| RBX1 | 837 | 6226 |
| RELA | -2976 | 5749 |
| RHEB | 2972 | 6691 |
| RING1 | -4420 | 4529 |
| RNF2 | 2363 | 7500 |
| RPA1 | -3261 | 8080 |
| RPA3 | -460 | 1331 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS19BP1 | -4624 | 1425 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS6KA1 | -2059 | 6292 |
| RPS6KA2 | -1618 | 6457 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RPTOR | -727 | -222 |
| RRAGA | -3091 | 8312 |
| RRAGC | 3617 | 7017 |
| RRAGD | -1676 | 3981 |
| SCMH1 | -3217 | 7093 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SERPINH1 | -3926 | 1350 |
| SESN1 | -2134 | 4595 |
| SESN2 | -1277 | 1608 |
| SIRT1 | 1673 | 6815 |
| SLC38A9 | 2111 | 6434 |
| SOD1 | -2945 | 6467 |
| SOD2 | 1263 | 6344 |
| SP1 | -1469 | 2146 |
| ST13 | -2891 | 6559 |
| STAT3 | 2390 | 7085 |
| STIP1 | -3501 | -119 |
| SZT2 | 1539 | 935 |
| TCIRG1 | -1767 | 4563 |
| TERF1 | 2470 | 5033 |
| TERF2 | 587 | 5105 |
| TERF2IP | -2489 | 7036 |
| TFDP1 | 3251 | 471 |
| TFDP2 | -3887 | 3770 |
| TINF2 | -3116 | 4849 |
| TNIK | -1519 | 4975 |
| TNRC6A | 3937 | 6086 |
| TNRC6B | 1337 | 787 |
| TP53 | -945 | 1992 |
| TPR | 3600 | 5135 |
| TRIB3 | 1743 | 563 |
| TXN | 345 | 339 |
| TXN2 | -4066 | 5130 |
| TXNRD1 | -851 | 214 |
| TXNRD2 | -1851 | -152 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2C | -2543 | 1584 |
| UBE2D1 | 2847 | 4705 |
| UBE2D2 | -2774 | 4272 |
| UBE2D3 | 2202 | 2455 |
| UBE2E1 | -429 | 3149 |
| UBE2S | 122 | -550 |
| UBN1 | -452 | 7888 |
| VCP | -3054 | 7877 |
| VEGFA | -1341 | 832 |
| VHL | -2469 | 2728 |
| WDR24 | -2666 | 2561 |
| WDR59 | -1986 | 7281 |
| YWHAE | 2292 | 6202 |
Ribosomal scanning and start codon recognition
| metric | value |
|---|---|
| setSize | 47 |
| pMANOVA | 3.98e-10 |
| p.adjustMANOVA | 1.4e-08 |
| s.dist | 0.551 |
| s.RNA | -0.548 |
| s.meth | -0.0613 |
| p.RNA | 8.38e-11 |
| p.meth | 0.468 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| EIF3B | -3814 | -643 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EIF3A | 1568 | 188 |
| EIF3B | -3814 | -643 |
| EIF3E | 610 | 4012 |
| EIF3F | -4609 | 1788 |
| EIF3G | -4542 | 1822 |
| EIF3H | -2925 | 5015 |
| EIF3I | -4128 | 2663 |
| EIF3J | 3510 | 3059 |
| EIF3K | -3415 | 8409 |
| EIF3L | -4533 | 6698 |
| EIF3M | 2210 | 7241 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4G1 | -2084 | 3220 |
| EIF4H | -4322 | 3675 |
| EIF5 | 2432 | 7143 |
| FAU | -4597 | 5991 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
Cellular responses to external stimuli
| metric | value |
|---|---|
| setSize | 397 |
| pMANOVA | 1.04e-09 |
| p.adjustMANOVA | 3.53e-08 |
| s.dist | 0.19 |
| s.RNA | -0.189 |
| s.meth | -0.0104 |
| p.RNA | 1.59e-10 |
| p.meth | 0.725 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| LAMTOR1 | -3908 | -649 |
| MAPK3 | -4654 | -479 |
| DCTN2 | -4181 | -467 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| AGO1 | -1699 | -803 |
| LAMTOR2 | -4436 | -288 |
| HIF1AN | -3821 | -320 |
| EHMT1 | -1867 | -506 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| NCF4 | -3378 | -141 |
| AJUBA | -567 | -835 |
| STIP1 | -3501 | -119 |
| TXNRD2 | -1851 | -152 |
| RPTOR | -727 | -222 |
| ATP6V0E2 | -1133 | -8 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ACD | -4048 | 3685 |
| ACTR10 | 2160 | 5133 |
| ACTR1A | -3110 | 886 |
| AGO1 | -1699 | -803 |
| AGO3 | 4554 | 8331 |
| AJUBA | -567 | -835 |
| AKT1S1 | -3490 | 5797 |
| ANAPC1 | -2044 | 3351 |
| ANAPC10 | 1009 | -306 |
| ANAPC11 | -4292 | 7059 |
| ANAPC15 | -4084 | 2693 |
| ANAPC16 | -1049 | 6873 |
| ANAPC2 | -3136 | 1387 |
| ANAPC4 | 4429 | 1495 |
| ANAPC5 | 908 | 3142 |
| ANAPC7 | 3490 | 869 |
| ARNT | 2384 | 5016 |
| ASNS | 1581 | 2242 |
| ATF3 | 4330 | 5006 |
| ATF4 | -1992 | 3847 |
| ATF5 | 2993 | 279 |
| ATM | 20 | 2443 |
| ATOX1 | -2570 | 8027 |
| ATP6V0B | -3239 | 4939 |
| ATP6V0C | 7 | 2508 |
| ATP6V0D1 | -1378 | 5821 |
| ATP6V0E1 | -2501 | 5554 |
| ATP6V0E2 | -1133 | -8 |
| ATP6V1A | 2373 | 3932 |
| ATP6V1B2 | 1474 | 2977 |
| ATP6V1C1 | 2649 | 3448 |
| ATP6V1D | 871 | 449 |
| ATP6V1E1 | 1207 | 6230 |
| ATP6V1F | -4025 | 2967 |
| ATP6V1G2 | 108 | 7771 |
| ATP6V1H | -994 | 5715 |
| ATR | 3357 | 3477 |
| BAG1 | 569 | 3503 |
| BAG2 | 1823 | 2917 |
| BAG3 | -2828 | 1533 |
| BAG4 | 2818 | 2195 |
| BAG5 | 671 | 5951 |
| BMI1 | 1215 | 4629 |
| C12orf66 | 2902 | 7834 |
| CABIN1 | -3524 | 3096 |
| CAMK2D | -1258 | 3808 |
| CAMK2G | -2604 | 31 |
| CAPZA1 | 3324 | 7829 |
| CAPZA2 | 3455 | 3750 |
| CAPZB | -1556 | 3064 |
| CAT | 1372 | -221 |
| CBX4 | -2808 | 5617 |
| CBX6 | -3228 | 7540 |
| CBX8 | -1650 | 73 |
| CCAR2 | -1306 | 1073 |
| CCNA2 | 1688 | 6920 |
| CCNE1 | 3783 | 6755 |
| CCNE2 | 1042 | 5076 |
| CCS | -4331 | 5087 |
| CDC16 | 1994 | 7052 |
| CDC23 | 1843 | 4397 |
| CDK2 | -1746 | 6577 |
| CDK4 | -4272 | 6700 |
| CDK6 | 3142 | 2094 |
| CDKN1A | 2610 | 7579 |
| CDKN1B | -1996 | 1658 |
| CDKN2A | 2101 | 4878 |
| CDKN2C | -3393 | 4213 |
| CDKN2D | -4602 | 5171 |
| CEBPB | 37 | 2587 |
| CEBPG | 2366 | 5011 |
| CITED2 | -93 | 6665 |
| CREBBP | -2371 | 6830 |
| CSRP1 | -79 | 3408 |
| CUL2 | 3543 | 6010 |
| CYBA | -2039 | 5379 |
| CYCS | 2507 | 2450 |
| DCTN2 | -4181 | -467 |
| DCTN3 | -3566 | 4086 |
| DCTN4 | 3602 | 3763 |
| DCTN5 | -1624 | 7654 |
| DCTN6 | 3077 | 6435 |
| DDIT3 | 1184 | 1641 |
| DEDD2 | -3321 | 2856 |
| DEPDC5 | 1787 | 1033 |
| DNAJA1 | 3185 | 5172 |
| DNAJA2 | 716 | 7945 |
| DNAJA4 | -731 | 2213 |
| DNAJB1 | -4240 | 5251 |
| DNAJB6 | -1165 | 7519 |
| DNAJC2 | 3874 | 421 |
| DYNC1H1 | -363 | 1172 |
| DYNC1I2 | 1771 | 261 |
| DYNC1LI1 | 3057 | 6081 |
| DYNC1LI2 | 2777 | 3137 |
| DYNLL1 | -2331 | 5391 |
| DYNLL2 | -3503 | 3308 |
| E2F1 | 2277 | 1130 |
| E2F2 | 1158 | 3021 |
| E2F3 | 3158 | 5634 |
| EED | 2485 | 2932 |
| EEF1A1 | -4296 | 2014 |
| EGLN1 | 779 | 5177 |
| EGLN2 | -4506 | 4388 |
| EHMT1 | -1867 | -506 |
| EHMT2 | -4004 | 5106 |
| EIF2AK1 | 1428 | 1917 |
| EIF2AK4 | -1627 | 6865 |
| EIF2S1 | 2445 | 6703 |
| EIF2S2 | 3398 | 5131 |
| EP300 | 1140 | 3364 |
| EP400 | -218 | 2028 |
| EPAS1 | 3726 | -699 |
| ERF | -4093 | 5827 |
| ERO1A | 4290 | -809 |
| ETS1 | -2992 | 4334 |
| ETS2 | -918 | 1436 |
| EZH2 | 4525 | 4485 |
| FAU | -4597 | 5991 |
| FKBP4 | -3165 | 4677 |
| FKBP5 | 4166 | 1867 |
| FLCN | 2232 | 2472 |
| FNIP1 | 3908 | 6015 |
| FOS | -3641 | 4083 |
| FZR1 | -2370 | 7430 |
| GCN1 | -1543 | 7280 |
| GPX1 | -4030 | 2183 |
| GRB10 | 1083 | 192 |
| GSK3B | -53 | 3637 |
| GSR | -1273 | 1990 |
| GSTP1 | -2214 | 6832 |
| HIF1A | 2136 | 4115 |
| HIF1AN | -3821 | -320 |
| HIGD1A | 2015 | 4139 |
| HIRA | -1304 | 6286 |
| HMGA1 | -4231 | 5560 |
| HSBP1 | 1933 | 1432 |
| HSF1 | -2309 | 5763 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| HSPA13 | 1170 | 4247 |
| HSPA14 | 4029 | 7441 |
| HSPA1A | -2393 | 1113 |
| HSPA1B | -808 | 755 |
| HSPA1L | -1936 | 336 |
| HSPA2 | -2606 | 5784 |
| HSPA4 | 1735 | 8237 |
| HSPA4L | 3658 | 7845 |
| HSPA9 | -476 | 5882 |
| HSPH1 | 2157 | 3890 |
| ID1 | -3700 | 5853 |
| ITFG2 | 1100 | 3363 |
| JUN | -3439 | 2775 |
| KAT5 | -2212 | 5607 |
| KDM6B | -1951 | 2846 |
| KPTN | -2646 | 7869 |
| LAMTOR1 | -3908 | -649 |
| LAMTOR2 | -4436 | -288 |
| LAMTOR3 | 2397 | 6767 |
| LAMTOR4 | -4065 | 1911 |
| LAMTOR5 | -3713 | 7083 |
| LIMD1 | 1448 | 2244 |
| LMNB1 | 4058 | 4104 |
| MAP2K3 | -1357 | 38 |
| MAP2K4 | 810 | 3168 |
| MAP2K6 | 2412 | 2172 |
| MAP2K7 | -3856 | 2099 |
| MAP3K5 | 2214 | 4831 |
| MAP4K4 | -447 | 7027 |
| MAPK1 | 300 | 2770 |
| MAPK14 | 586 | 2235 |
| MAPK3 | -4654 | -479 |
| MAPK7 | -556 | 3019 |
| MAPK8 | 1601 | 6176 |
| MAPK9 | -1494 | 1159 |
| MAPKAPK2 | -3294 | 1423 |
| MAPKAPK3 | 486 | 58 |
| MDM2 | 4628 | 1092 |
| MDM4 | 3853 | 1115 |
| MINK1 | -3455 | 2629 |
| MIOS | 1051 | 3553 |
| MLST8 | -3610 | 3421 |
| MOV10 | 4273 | 7640 |
| MRPL18 | -756 | 3878 |
| MT1F | -1811 | 2906 |
| MT1X | 1813 | 3532 |
| MT2A | 2794 | 3780 |
| MTF1 | 3130 | 2958 |
| MTOR | -2622 | 1240 |
| NBN | 4170 | 1983 |
| NCF4 | -3378 | -141 |
| NDC1 | 131 | -274 |
| NPRL2 | -2764 | 5068 |
| NPRL3 | 408 | 7970 |
| NR3C1 | 1145 | 4250 |
| NR3C2 | -1917 | 6632 |
| NUDT2 | -1434 | 6673 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| P4HB | -3085 | 6831 |
| PHC1 | -4242 | 606 |
| PHC2 | -1130 | 4319 |
| PHC3 | 3313 | 522 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PPP1R15A | -3660 | 5649 |
| PRDX1 | 1742 | 4095 |
| PRDX2 | -2637 | 6462 |
| PRDX3 | 2541 | 3939 |
| PRDX5 | -4334 | 7719 |
| PRDX6 | -2233 | 4160 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTGES3 | 2915 | 2735 |
| RAD50 | 4602 | 179 |
| RAE1 | -413 | 710 |
| RANBP2 | 3159 | 4436 |
| RB1 | 3165 | 1518 |
| RBBP4 | 474 | 2574 |
| RBX1 | 837 | 6226 |
| RELA | -2976 | 5749 |
| RHEB | 2972 | 6691 |
| RING1 | -4420 | 4529 |
| RNF2 | 2363 | 7500 |
| RPA1 | -3261 | 8080 |
| RPA3 | -460 | 1331 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS19BP1 | -4624 | 1425 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS6KA1 | -2059 | 6292 |
| RPS6KA2 | -1618 | 6457 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RPTOR | -727 | -222 |
| RRAGA | -3091 | 8312 |
| RRAGC | 3617 | 7017 |
| RRAGD | -1676 | 3981 |
| SCMH1 | -3217 | 7093 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SERPINH1 | -3926 | 1350 |
| SESN1 | -2134 | 4595 |
| SESN2 | -1277 | 1608 |
| SIRT1 | 1673 | 6815 |
| SLC38A9 | 2111 | 6434 |
| SOD1 | -2945 | 6467 |
| SOD2 | 1263 | 6344 |
| SP1 | -1469 | 2146 |
| ST13 | -2891 | 6559 |
| STAT3 | 2390 | 7085 |
| STIP1 | -3501 | -119 |
| SZT2 | 1539 | 935 |
| TCIRG1 | -1767 | 4563 |
| TERF1 | 2470 | 5033 |
| TERF2 | 587 | 5105 |
| TERF2IP | -2489 | 7036 |
| TFDP1 | 3251 | 471 |
| TFDP2 | -3887 | 3770 |
| TINF2 | -3116 | 4849 |
| TNIK | -1519 | 4975 |
| TNRC6A | 3937 | 6086 |
| TNRC6B | 1337 | 787 |
| TP53 | -945 | 1992 |
| TPR | 3600 | 5135 |
| TRIB3 | 1743 | 563 |
| TXN | 345 | 339 |
| TXN2 | -4066 | 5130 |
| TXNRD1 | -851 | 214 |
| TXNRD2 | -1851 | -152 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2C | -2543 | 1584 |
| UBE2D1 | 2847 | 4705 |
| UBE2D2 | -2774 | 4272 |
| UBE2D3 | 2202 | 2455 |
| UBE2E1 | -429 | 3149 |
| UBE2S | 122 | -550 |
| UBN1 | -452 | 7888 |
| VCP | -3054 | 7877 |
| VEGFA | -1341 | 832 |
| VHL | -2469 | 2728 |
| WDR24 | -2666 | 2561 |
| WDR59 | -1986 | 7281 |
| YWHAE | 2292 | 6202 |
Interferon Signaling
| metric | value |
|---|---|
| setSize | 142 |
| pMANOVA | 7.49e-09 |
| p.adjustMANOVA | 2.48e-07 |
| s.dist | 0.3 |
| s.RNA | 0.298 |
| s.meth | -0.0344 |
| p.RNA | 1.03e-09 |
| p.meth | 0.481 |
| Gene | RNA | meth |
|---|---|---|
| ISG15 | 4539 | -542 |
| EIF4E3 | 3243 | -728 |
| BST2 | 3234 | -711 |
| USP18 | 4630 | -387 |
| MX2 | 4636 | -241 |
| IFIT2 | 4559 | -227 |
| OAS1 | 4608 | -193 |
| PDE12 | 1736 | -503 |
| PPM1B | 3762 | -194 |
| PTPN1 | 1532 | -296 |
| ISG20 | 3220 | -116 |
| TRIM21 | 3173 | -41 |
| NDC1 | 131 | -274 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ABCE1 | 2436 | 2902 |
| ADAR | 4354 | 5945 |
| ARIH1 | 2692 | 5841 |
| B2M | 2527 | 3658 |
| BST2 | 3234 | -711 |
| CAMK2D | -1258 | 3808 |
| CAMK2G | -2604 | 31 |
| CD44 | -732 | 4410 |
| DDX58 | 4611 | 2919 |
| EGR1 | -1941 | 7109 |
| EIF2AK2 | 4648 | 189 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4A3 | -3302 | 5329 |
| EIF4E | 3529 | 5614 |
| EIF4E2 | -1364 | 2810 |
| EIF4E3 | 3243 | -728 |
| EIF4G1 | -2084 | 3220 |
| EIF4G2 | 1209 | 6231 |
| EIF4G3 | 2013 | 900 |
| FLNB | -950 | 3896 |
| GBP3 | 376 | 7707 |
| HERC5 | 4645 | 1229 |
| HLA-A | -4490 | 2274 |
| HLA-B | -333 | 513 |
| HLA-C | -168 | 6790 |
| HLA-E | -1262 | 3744 |
| HLA-F | -4367 | -24 |
| HLA-H | -4088 | 7849 |
| ICAM1 | -1902 | 6201 |
| IFI30 | 2895 | 3554 |
| IFI35 | 4496 | 208 |
| IFI6 | 4580 | 920 |
| IFIT1 | 4635 | 25 |
| IFIT2 | 4559 | -227 |
| IFIT3 | 4641 | 7117 |
| IFIT5 | 4531 | 7258 |
| IFITM1 | 2245 | 818 |
| IFNAR1 | 1797 | 6059 |
| IFNAR2 | -1405 | 1950 |
| IFNGR1 | 1891 | 4337 |
| IFNGR2 | 2151 | 6521 |
| IP6K2 | -2836 | 7313 |
| IRF1 | 3500 | 5454 |
| IRF2 | 3001 | 5323 |
| IRF3 | -2843 | 2803 |
| IRF4 | 3107 | 4603 |
| IRF5 | 87 | 8203 |
| IRF7 | 4358 | 6617 |
| IRF9 | 4504 | 5128 |
| ISG15 | 4539 | -542 |
| ISG20 | 3220 | -116 |
| JAK1 | -3728 | 6986 |
| JAK2 | 4633 | 6248 |
| KPNA1 | 2627 | 6172 |
| KPNA2 | 3157 | 843 |
| KPNA3 | 3283 | 1404 |
| KPNA4 | 3489 | 8152 |
| KPNA5 | 4177 | 1689 |
| KPNB1 | 3511 | 5921 |
| MAPK3 | -4654 | -479 |
| MT2A | 2794 | 3780 |
| MX1 | 4607 | 1151 |
| MX2 | 4636 | -241 |
| NDC1 | 131 | -274 |
| NEDD4 | 3533 | 6220 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| OAS1 | 4608 | -193 |
| OAS2 | 4638 | 3133 |
| OAS3 | 4612 | 5423 |
| OASL | 4547 | 6420 |
| PDE12 | 1736 | -503 |
| PIAS1 | 4043 | 7693 |
| PIN1 | -4555 | 3781 |
| PLCG1 | -1509 | 5809 |
| PML | 4377 | 1165 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PPM1B | 3762 | -194 |
| PRKCD | 1080 | 8196 |
| PSMB8 | 957 | 1753 |
| PTPN1 | 1532 | -296 |
| PTPN11 | 942 | 3777 |
| PTPN2 | 2951 | 3176 |
| PTPN6 | -98 | 2545 |
| RAE1 | -413 | 710 |
| RANBP2 | 3159 | 4436 |
| RNASEL | 4023 | 3080 |
| RPS27A | -4637 | 2492 |
| SAMHD1 | 3588 | 7360 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SOCS1 | 1008 | 5666 |
| SOCS3 | -3912 | 698 |
| SP100 | 4614 | 3034 |
| STAT1 | 4586 | 956 |
| STAT2 | 4613 | 3486 |
| SUMO1 | 2185 | 4431 |
| TPR | 3600 | 5135 |
| TRIM14 | 3198 | 1706 |
| TRIM2 | -3087 | 2382 |
| TRIM21 | 3173 | -41 |
| TRIM22 | 4631 | 1106 |
| TRIM25 | 4122 | 6656 |
| TRIM26 | 2044 | 4604 |
| TRIM35 | -1432 | 4844 |
| TRIM38 | 4581 | 5525 |
| TRIM45 | 624 | 5188 |
| TRIM46 | 568 | 3191 |
| TRIM5 | 4590 | 5690 |
| TRIM62 | -227 | 6609 |
| TRIM68 | -1944 | -335 |
| TRIM8 | -878 | 4640 |
| TYK2 | -1202 | 1909 |
| UBA52 | -4418 | 4404 |
| UBA7 | 1257 | 3041 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2E1 | -429 | 3149 |
| UBE2L6 | 4230 | 765 |
| UBE2N | 1732 | 6764 |
| USP18 | 4630 | -387 |
| XAF1 | 4649 | 4696 |
Infectious disease
| metric | value |
|---|---|
| setSize | 486 |
| pMANOVA | 4.63e-08 |
| p.adjustMANOVA | 1.49e-06 |
| s.dist | 0.156 |
| s.RNA | -0.156 |
| s.meth | -0.00146 |
| p.RNA | 6.58e-09 |
| p.meth | 0.957 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| ANTXR2 | -3317 | -806 |
| MAPK3 | -4654 | -479 |
| GGT1 | -2671 | -730 |
| PRKAR1B | -2636 | -687 |
| TLR9 | -4103 | -408 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| GNG7 | -2766 | -475 |
| PSMD9 | -4063 | -186 |
| COMT | -2506 | -295 |
| RPL36 | -4617 | -158 |
| S1PR1 | -2183 | -333 |
| RAB7A | -1246 | -526 |
| DUSP16 | -2410 | -243 |
| GNAS | -1888 | -276 |
| GNB1 | -1144 | -391 |
| MAP2K1 | -710 | -148 |
| GNGT2 | -480 | -71 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ABI1 | 3632 | 523 |
| ABI2 | 1304 | 1460 |
| ABL1 | -2415 | 5977 |
| ACTB | -398 | 4265 |
| ACTG1 | -3749 | 6428 |
| ACTR2 | 3409 | 4951 |
| ACTR3 | 1752 | 4499 |
| ADAM17 | 3950 | 4714 |
| ADCY4 | 2574 | 6234 |
| ADCY7 | -1481 | 2400 |
| ADCY9 | -3842 | 8419 |
| ADM | -3334 | 7632 |
| ADORA2A | -3721 | 8364 |
| ADRB2 | -2536 | 5274 |
| AHCYL1 | 1228 | 6911 |
| ANTXR2 | -3317 | -806 |
| AP1B1 | -2162 | 7607 |
| AP1G1 | 1339 | 6363 |
| AP1M1 | -3952 | 2151 |
| AP1S3 | 1229 | 5075 |
| AP2A1 | 143 | 1895 |
| AP2M1 | -4214 | 5734 |
| AP2S1 | -2753 | 3997 |
| ARF1 | -3211 | 8404 |
| ARPC1B | -2892 | 2843 |
| ARPC2 | 469 | 5703 |
| ARPC3 | 2190 | 4838 |
| ARPC5 | 2839 | 2343 |
| ATP1A1 | 437 | 5489 |
| ATP6V1H | -994 | 5715 |
| B2M | 2527 | 3658 |
| BAIAP2 | -2113 | 6308 |
| BANF1 | -4277 | 4199 |
| BECN1 | 2040 | 7998 |
| BRD4 | 2467 | -833 |
| BRK1 | -4495 | 8055 |
| BTRC | -3793 | 66 |
| C3AR1 | 4571 | 1729 |
| CALM1 | 1204 | 3996 |
| CALR | 1654 | 3555 |
| CANX | 1496 | 7355 |
| CASP1 | 4136 | -381 |
| CBL | -1578 | 7616 |
| CBX1 | -2066 | 4266 |
| CCNH | 4336 | 5990 |
| CCNK | 3685 | 2118 |
| CCNT1 | -346 | 211 |
| CD247 | -3643 | 3173 |
| CD4 | -1952 | 6004 |
| CDC42 | 3092 | 7063 |
| CDK7 | 3468 | 3672 |
| CDK9 | -4432 | 6663 |
| CEBPD | -1956 | 1324 |
| CHMP1A | -2248 | 982 |
| CHMP2A | -2940 | 7013 |
| CHMP2B | 3798 | 5744 |
| CHMP3 | 1593 | -59 |
| CHMP4A | 1274 | 1773 |
| CHMP4B | -2895 | 4124 |
| CHMP5 | 4526 | 1922 |
| CHMP6 | -4489 | 1561 |
| CHMP7 | -2381 | 6937 |
| CLTA | -1596 | 1476 |
| CLTC | 355 | 2682 |
| COMT | -2506 | -295 |
| CORO1A | -4409 | 3099 |
| CPSF4 | -3066 | 7194 |
| CRBN | 2713 | 5723 |
| CREB1 | 2778 | 5066 |
| CRK | 2811 | 5956 |
| CTDP1 | -3829 | 1498 |
| CTNNB1 | 555 | 6731 |
| CTNND1 | 4164 | 2992 |
| CTSL | 3889 | 8394 |
| CUL5 | 4310 | 5417 |
| CXCR4 | -1226 | 6685 |
| CYBA | -2039 | 5379 |
| CYFIP1 | -408 | 8327 |
| CYFIP2 | -637 | 4244 |
| DAXX | -1619 | 3531 |
| DBP | -2865 | 6319 |
| DDX5 | -2253 | 1749 |
| DNAJC3 | 3023 | 8319 |
| DPEP2 | 1477 | 5071 |
| DUSP16 | -2410 | -243 |
| DUT | -3988 | 4927 |
| DVL1 | -4659 | 5359 |
| DVL2 | -4174 | 646 |
| DVL3 | -3362 | 8314 |
| DYNC1H1 | -363 | 1172 |
| DYNC1I2 | 1771 | 261 |
| DYNC1LI1 | 3057 | 6081 |
| DYNC1LI2 | 2777 | 3137 |
| DYNLL1 | -2331 | 5391 |
| DYNLL2 | -3503 | 3308 |
| EED | 2485 | 2932 |
| EEF2 | -4566 | 1316 |
| EIF2AK2 | 4648 | 189 |
| ELL | -3273 | 2306 |
| ELMO1 | -1875 | 4458 |
| ELMO2 | 1279 | 3635 |
| ENO1 | -1582 | 3952 |
| ENTPD1 | 2547 | 7155 |
| ENTPD5 | 4264 | 3843 |
| EPS15 | 4267 | 4996 |
| ERCC2 | -2741 | 1785 |
| ERCC3 | -66 | 3558 |
| EZH2 | 4525 | 4485 |
| FAU | -4597 | 5991 |
| FEN1 | -2465 | 5510 |
| FGR | 164 | 6452 |
| FKBP1A | 1355 | 6135 |
| FURIN | -4427 | 8374 |
| FYN | -1416 | 2811 |
| FZD7 | 1667 | 2395 |
| GANAB | -4187 | 2335 |
| GGT1 | -2671 | -730 |
| GIPR | -142 | 462 |
| GNAI2 | -1841 | 5421 |
| GNAI3 | 2197 | 705 |
| GNAS | -1888 | -276 |
| GNB1 | -1144 | -391 |
| GNB2 | -1967 | 6049 |
| GNB4 | 4237 | 8172 |
| GNB5 | -876 | 5796 |
| GNG2 | 237 | 4290 |
| GNG3 | 3973 | 8393 |
| GNG4 | 3231 | 7006 |
| GNG5 | 1165 | 3751 |
| GNG7 | -2766 | -475 |
| GNGT2 | -480 | -71 |
| GPS2 | -1127 | 1242 |
| GRB2 | -584 | 5992 |
| GRSF1 | 865 | 1474 |
| GSK3A | -2224 | 4821 |
| GSK3B | -53 | 3637 |
| GTF2A1 | 2579 | 3947 |
| GTF2A2 | 506 | 4288 |
| GTF2B | 3585 | 1777 |
| GTF2E2 | 1143 | 2527 |
| GTF2F1 | -3508 | 1349 |
| GTF2F2 | 880 | 4275 |
| GTF2H3 | 1084 | 8269 |
| GTF2H4 | -3844 | 6171 |
| GTF2H5 | 3420 | 1888 |
| HBEGF | -3076 | 8169 |
| HDAC2 | 196 | 4593 |
| HDAC3 | -2003 | 8308 |
| HGS | 165 | 2237 |
| HLA-A | -4490 | 2274 |
| HMGA1 | -4231 | 5560 |
| HNRNPK | -1257 | 5618 |
| HRH2 | 2546 | 7921 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| HSPA1A | -2393 | 1113 |
| IL1RAP | 2764 | 39 |
| IL6R | -496 | 6551 |
| IMPDH1 | -1093 | 6 |
| IMPDH2 | -4611 | 5354 |
| IPO5 | -1368 | 8363 |
| IRS1 | -3373 | 4427 |
| ISG15 | 4539 | -542 |
| ITGA4 | 1898 | 4664 |
| ITPR1 | -768 | 6634 |
| ITPR2 | 2201 | 4474 |
| ITPR3 | -742 | 2887 |
| JAK1 | -3728 | 6986 |
| JAK2 | 4633 | 6248 |
| JUN | -3439 | 2775 |
| KPNA1 | 2627 | 6172 |
| KPNA2 | 3157 | 843 |
| KPNA3 | 3283 | 1404 |
| KPNA4 | 3489 | 8152 |
| KPNA5 | 4177 | 1689 |
| KPNB1 | 3511 | 5921 |
| LCK | -3481 | 2504 |
| LIG1 | -2821 | 1862 |
| LIG4 | 4092 | 6928 |
| MAP2K1 | -710 | -148 |
| MAP2K2 | -4596 | 8056 |
| MAP2K3 | -1357 | 38 |
| MAP2K4 | 810 | 3168 |
| MAP2K6 | 2412 | 2172 |
| MAP2K7 | -3856 | 2099 |
| MAPK1 | 300 | 2770 |
| MAPK14 | 586 | 2235 |
| MAPK3 | -4654 | -479 |
| MAPK8 | 1601 | 6176 |
| MGAT1 | -2500 | 3340 |
| MNAT1 | 56 | 2609 |
| MOGS | -3879 | 4407 |
| MVB12A | -3102 | 7863 |
| MYH9 | -2293 | 3393 |
| MYO9B | -344 | 3151 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| NCK1 | 76 | 1103 |
| NCKAP1L | 2567 | 1935 |
| NCKIPSD | -4023 | 8021 |
| NCOR1 | 878 | 1101 |
| NCOR2 | -979 | 580 |
| NDC1 | 131 | -274 |
| NEDD4L | -2560 | 223 |
| NELFA | -1044 | 6889 |
| NELFB | -4380 | 5472 |
| NELFCD | -174 | 4159 |
| NELFE | -2421 | 8447 |
| NFKB2 | -2305 | 2526 |
| NLRP3 | 964 | 6403 |
| NMT1 | 2748 | 5677 |
| NMT2 | 1322 | 2421 |
| NOXA1 | 61 | 6268 |
| NR3C1 | 1145 | 4250 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| P2RX4 | -2093 | 621 |
| PABPN1 | -2788 | 7278 |
| PACS1 | -3061 | 5954 |
| PAK2 | 2849 | 2509 |
| PARP1 | -3259 | 377 |
| PARP10 | 3622 | 249 |
| PARP14 | 4626 | 288 |
| PARP16 | -3690 | 3444 |
| PARP4 | 4357 | 2826 |
| PARP6 | -247 | 7359 |
| PARP8 | 1899 | -314 |
| PARP9 | 4644 | 3387 |
| PDCD6IP | 3888 | 3740 |
| PIK3R4 | 795 | 2082 |
| PLCG1 | -1509 | 5809 |
| PLCG2 | -279 | 6178 |
| PLK2 | -2216 | 8395 |
| PML | 4377 | 1165 |
| POLR2A | 69 | -175 |
| POLR2B | 704 | 1497 |
| POLR2C | -3573 | 4506 |
| POLR2D | 1768 | 1352 |
| POLR2E | -4269 | 2995 |
| POLR2F | -4459 | 6542 |
| POLR2G | -4291 | 8051 |
| POLR2H | -4045 | 7582 |
| POLR2I | -4354 | 6360 |
| POLR2K | 2165 | 2463 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PPIA | -3957 | 5622 |
| PRKACA | -456 | 3985 |
| PRKACB | -591 | 7740 |
| PRKAR1A | 1757 | 3914 |
| PRKAR1B | -2636 | -687 |
| PRKAR2A | 717 | 532 |
| PRKCSH | -4306 | 5320 |
| PSIP1 | 3256 | 2179 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PSTPIP1 | -3651 | 2324 |
| PTGER2 | -932 | 7393 |
| PTGER4 | 781 | 3095 |
| PTK2 | 498 | 2498 |
| PYCARD | -1372 | 3155 |
| RAB5A | 3918 | 1760 |
| RAB7A | -1246 | -526 |
| RAC1 | 3104 | 7511 |
| RAE1 | -413 | 710 |
| RAN | -1758 | 2287 |
| RANBP1 | -2086 | 1651 |
| RANBP2 | 3159 | 4436 |
| RANGAP1 | -2765 | 6695 |
| RB1 | 3165 | 1518 |
| RBBP4 | 474 | 2574 |
| RBX1 | 837 | 6226 |
| RCC1 | -4647 | 6687 |
| RELA | -2976 | 5749 |
| RHBDF2 | 323 | 4216 |
| RNF213 | 4014 | 3702 |
| RNGTT | 1034 | 1738 |
| RNMT | 3501 | 2751 |
| ROCK1 | 4407 | 2216 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| S1PR1 | -2183 | -333 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SFPQ | 2604 | 6453 |
| SH3GL1 | -3963 | 6433 |
| SIGMAR1 | -2269 | 5834 |
| SKP1 | 2003 | 3193 |
| SLC25A4 | 681 | 7484 |
| SNF8 | -2683 | 7542 |
| SRC | 831 | -92 |
| SSRP1 | -3327 | 2951 |
| ST3GAL1 | -2856 | 5875 |
| ST3GAL2 | -2835 | 2056 |
| ST3GAL3 | -2285 | 3508 |
| ST3GAL4 | -3883 | 2599 |
| ST6GAL1 | -1689 | 3705 |
| ST6GALNAC3 | -2399 | 7567 |
| ST6GALNAC4 | -2771 | 1062 |
| STAM | 2700 | 1978 |
| STAM2 | 4400 | 4717 |
| STX1A | -1470 | 1045 |
| STX1B | 3179 | 865 |
| SUGT1 | 3282 | 6398 |
| SUMO1 | 2185 | 4431 |
| SUPT16H | -290 | 2239 |
| SUPT4H1 | -1091 | 7521 |
| SUPT5H | -2806 | 5377 |
| SYK | -23 | 3901 |
| TAF10 | -2438 | 2748 |
| TAF11 | 3929 | -261 |
| TAF12 | 916 | 486 |
| TAF13 | 3630 | 3314 |
| TAF15 | -3755 | 7204 |
| TAF2 | 4206 | 1412 |
| TAF3 | 3187 | 7268 |
| TAF4 | -1024 | 5640 |
| TAF4B | 228 | 716 |
| TAF5 | 1387 | 3006 |
| TAF6 | -2577 | 4411 |
| TAF7 | -2170 | 6649 |
| TAF9 | 3069 | 759 |
| TBK1 | 4593 | 6515 |
| TBL1XR1 | 1388 | 1367 |
| TCEA1 | 2228 | 2742 |
| TGFB1 | -2920 | 4353 |
| TLR2 | 3408 | 6797 |
| TLR9 | -4103 | -408 |
| TPR | 3600 | 5135 |
| TRIM27 | 1703 | 5362 |
| TRIM28 | -4513 | 3417 |
| TSG101 | 2169 | 1787 |
| TUBB | -1422 | 3715 |
| TXN | 345 | 339 |
| TXNIP | 1397 | 3975 |
| TXNRD1 | -851 | 214 |
| TYK2 | -1202 | 1909 |
| UBA52 | -4418 | 4404 |
| UBAP1 | -1172 | 958 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2I | -2449 | 3654 |
| UVRAG | 4073 | 1515 |
| VAMP1 | -2168 | 4166 |
| VAMP2 | -1376 | 536 |
| VAV1 | -3943 | 6946 |
| VAV2 | 1189 | 7727 |
| VAV3 | -2987 | 8297 |
| VCP | -3054 | 7877 |
| VEGFA | -1341 | 832 |
| VHL | -2469 | 2728 |
| VIPR1 | -1806 | 1741 |
| VPS25 | -2328 | 1068 |
| VPS28 | -4260 | 6113 |
| VPS33B | -2147 | 1344 |
| VPS36 | 4494 | 285 |
| VPS37A | 3865 | 7391 |
| VPS37B | -3958 | 2190 |
| VPS37C | 1662 | 4251 |
| VPS4A | -4319 | 1747 |
| VTA1 | 3587 | 6287 |
| WASF1 | -1557 | 763 |
| WASF2 | -141 | 1239 |
| WASL | 2271 | 7402 |
| WIPF1 | -1252 | 2905 |
| WIPF2 | 2250 | 568 |
| XPO1 | 4316 | 5628 |
| XRCC4 | 2816 | 6580 |
| XRCC5 | 989 | 3525 |
| XRCC6 | -2114 | 2815 |
| YES1 | 842 | -624 |
| ZCRB1 | 3332 | 2608 |
Metabolism of RNA
| metric | value |
|---|---|
| setSize | 535 |
| pMANOVA | 4.81e-08 |
| p.adjustMANOVA | 1.5e-06 |
| s.dist | 0.147 |
| s.RNA | -0.141 |
| s.meth | -0.0404 |
| p.RNA | 3.79e-08 |
| p.meth | 0.116 |
| Gene | RNA | meth |
|---|---|---|
| RPS2 | -4667 | -712 |
| SNU13 | -4216 | -644 |
| RPS23 | -4487 | -355 |
| SMG6 | -2308 | -684 |
| NOP14 | -2020 | -739 |
| RPS8 | -4077 | -349 |
| TXNL4A | -4343 | -317 |
| ZFP36 | -3648 | -336 |
| EXOSC2 | -3220 | -380 |
| SF3A2 | -3065 | -385 |
| RRP9 | -4264 | -254 |
| TRMT12 | -2164 | -497 |
| TRMT44 | -1493 | -658 |
| NOB1 | -3642 | -264 |
| SNRPN | -983 | -769 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| SMG5 | -2243 | -216 |
| FBL | -4641 | -91 |
| WDR77 | -514 | -650 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ACTB | -398 | 4265 |
| ADAR | 4354 | 5945 |
| ADARB1 | -2160 | 6489 |
| ADAT1 | 1527 | 3001 |
| ADAT2 | 2976 | 6255 |
| ADAT3 | -2352 | 1356 |
| AKT1 | -4019 | 4230 |
| ALKBH8 | 999 | 2320 |
| ALYREF | -3417 | 3415 |
| ANP32A | 320 | 3049 |
| AQR | 2714 | 383 |
| BMS1 | -1396 | 282 |
| BUD31 | -1233 | 4790 |
| BYSL | -4246 | 5920 |
| C1D | 4019 | 3664 |
| C2orf49 | 3102 | 4785 |
| CASC3 | -2347 | 3341 |
| CCAR1 | 4417 | 6138 |
| CCNH | 4336 | 5990 |
| CD2BP2 | -3858 | 1801 |
| CD44 | -732 | 4410 |
| CDC40 | 3352 | 3353 |
| CDC5L | 2788 | 985 |
| CDK7 | 3468 | 3672 |
| CDKAL1 | 2522 | -182 |
| CHERP | -2591 | 6160 |
| CLNS1A | 1913 | 5285 |
| CLP1 | -1981 | 2956 |
| CNOT1 | 709 | 2760 |
| CNOT10 | 2407 | 1988 |
| CNOT11 | 2654 | 2648 |
| CNOT3 | -1067 | 3459 |
| CNOT4 | 4262 | 2251 |
| CNOT6 | 4054 | 6051 |
| CNOT6L | 378 | 4335 |
| CNOT7 | 1995 | 6504 |
| CNOT8 | -444 | 5201 |
| CPSF1 | -1414 | 6607 |
| CPSF2 | 2115 | 2298 |
| CPSF3 | 2534 | -402 |
| CPSF4 | -3066 | 7194 |
| CRNKL1 | 2080 | 8053 |
| CSNK1D | -3971 | 6586 |
| CSNK1E | -3456 | 7038 |
| CSTF1 | -1983 | 6895 |
| CTNNBL1 | -1473 | 6402 |
| CTU1 | -4383 | 3402 |
| CTU2 | -3197 | 7861 |
| CWC15 | -106 | 6708 |
| CWC22 | 3825 | 5028 |
| CWC27 | 3842 | 3898 |
| DCAF13 | -705 | 1417 |
| DCP1A | 2304 | 4270 |
| DCP1B | -1145 | 5101 |
| DCP2 | 3739 | -280 |
| DCPS | -3917 | 4089 |
| DDX1 | 1379 | 1227 |
| DDX20 | -82 | 5356 |
| DDX21 | 3996 | 7489 |
| DDX23 | -1849 | 7573 |
| DDX42 | -2379 | 962 |
| DDX46 | 2868 | 4739 |
| DDX47 | 1480 | 899 |
| DDX49 | -3784 | 3923 |
| DDX5 | -2253 | 1749 |
| DDX52 | 4642 | 3608 |
| DDX6 | 1211 | 3357 |
| DHX16 | -3159 | 2827 |
| DHX37 | -2301 | 6256 |
| DHX9 | -1809 | 6426 |
| DIS3 | 4383 | 4903 |
| DNAJC8 | 1093 | 911 |
| DUS2 | -1427 | 5732 |
| EBNA1BP2 | -2353 | 1408 |
| EDC3 | -3839 | 4418 |
| EDC4 | -2858 | 2275 |
| EFTUD2 | -1398 | 8248 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4A3 | -3302 | 5329 |
| EIF4B | -3804 | 3082 |
| EIF4E | 3529 | 5614 |
| EIF4G1 | -2084 | 3220 |
| ELAC2 | -2787 | 5479 |
| ELAVL1 | -1780 | 6903 |
| ENPP2 | 3955 | 7490 |
| ERCC2 | -2741 | 1785 |
| ERCC3 | -66 | 3558 |
| ERI1 | 4502 | -203 |
| ETF1 | 2978 | 7120 |
| EXOSC1 | 1694 | 7262 |
| EXOSC10 | 2058 | 1784 |
| EXOSC2 | -3220 | -380 |
| EXOSC3 | 791 | 4976 |
| EXOSC4 | -3235 | 5215 |
| EXOSC5 | -3924 | 472 |
| EXOSC6 | -29 | 3480 |
| EXOSC7 | -4477 | 4110 |
| EXOSC8 | 1227 | 5376 |
| FAM98B | 3366 | 3578 |
| FAU | -4597 | 5991 |
| FBL | -4641 | -91 |
| FCF1 | 1672 | 5745 |
| FIP1L1 | 162 | 2997 |
| FTSJ3 | 81 | 4982 |
| FUS | 103 | 1063 |
| FYTTD1 | 2135 | 4195 |
| GAR1 | -1241 | 3773 |
| GCFC2 | 3694 | -589 |
| GEMIN2 | 4018 | -776 |
| GEMIN4 | -3463 | 6872 |
| GEMIN5 | -3030 | -107 |
| GEMIN6 | -674 | 416 |
| GEMIN7 | -3401 | 360 |
| GLE1 | -2411 | 5898 |
| GNL3 | 743 | 1860 |
| GSPT1 | 3544 | 4369 |
| GTF2F1 | -3508 | 1349 |
| GTF2F2 | 880 | 4275 |
| GTF2H3 | 1084 | 8269 |
| GTF2H4 | -3844 | 6171 |
| GTF2H5 | 3420 | 1888 |
| GTPBP3 | -3666 | 5118 |
| HBS1L | 1676 | 491 |
| HEATR1 | 972 | 6383 |
| HNRNPA0 | -4656 | 570 |
| HNRNPA2B1 | 216 | 2597 |
| HNRNPC | -1869 | 740 |
| HNRNPD | -3352 | 2614 |
| HNRNPF | -3141 | 3537 |
| HNRNPH1 | 1920 | 2165 |
| HNRNPK | -1257 | 5618 |
| HNRNPL | -4271 | 3377 |
| HNRNPM | -2846 | 6942 |
| HNRNPR | -271 | 4913 |
| HNRNPU | -802 | 5672 |
| HNRNPUL1 | -4094 | 3111 |
| HSPA1A | -2393 | 1113 |
| HSPB1 | -2998 | 2007 |
| IGF2BP3 | 3325 | 3867 |
| IMP3 | -3902 | 6106 |
| IMP4 | -4106 | 4273 |
| ISG20L2 | 1909 | 2767 |
| ISY1 | -3929 | 2047 |
| KHSRP | -1816 | 840 |
| KRR1 | 2512 | -810 |
| LCMT2 | -2800 | 4352 |
| LSM1 | -2713 | 2888 |
| LSM10 | -1832 | 4339 |
| LSM11 | -3740 | 2782 |
| LSM2 | -3267 | 6188 |
| LSM3 | -63 | 2600 |
| LSM4 | -2629 | 4005 |
| LSM5 | -1053 | 5619 |
| LSM6 | -2225 | 6699 |
| LSM7 | -4645 | 5137 |
| LSM8 | 2351 | 3026 |
| LTV1 | 887 | 2910 |
| MAPK14 | 586 | 2235 |
| MAPKAPK2 | -3294 | 1423 |
| METTL1 | 458 | 7002 |
| METTL14 | 4202 | 6593 |
| MNAT1 | 56 | 2609 |
| MPHOSPH10 | 4283 | 5469 |
| MPHOSPH6 | 1514 | 6242 |
| MRM1 | -3796 | 2116 |
| MTERF4 | -3319 | 5833 |
| MTO1 | 3433 | 1508 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| NCL | -2485 | 6814 |
| NDC1 | 131 | -274 |
| NHP2 | -4201 | 6994 |
| NIP7 | 727 | 5750 |
| NOB1 | -3642 | -264 |
| NOC4L | 1027 | 5529 |
| NOL11 | 1529 | -392 |
| NOL12 | -2859 | 6019 |
| NOL6 | -2343 | 6101 |
| NOL9 | 3048 | -796 |
| NOP10 | -3662 | 2404 |
| NOP14 | -2020 | -739 |
| NOP2 | -3857 | 5056 |
| NOP56 | -1965 | 117 |
| NOP58 | 3009 | 2119 |
| NSUN2 | 1036 | -108 |
| NSUN4 | 3419 | 782 |
| NSUN6 | 3535 | 4451 |
| NUDT21 | 1829 | 5050 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| NXF1 | 546 | 1949 |
| NXT1 | -4284 | 665 |
| PABPC1 | 1884 | 3737 |
| PABPN1 | -2788 | 7278 |
| PAIP1 | 914 | -399 |
| PAN2 | 1021 | 2152 |
| PAN3 | 4374 | -808 |
| PAPOLA | 2261 | 3899 |
| PARN | 2667 | 5144 |
| PATL1 | 4467 | 6855 |
| PCBP1 | -4151 | 1817 |
| PCBP2 | -3442 | 1023 |
| PDCD11 | -2458 | 1980 |
| PDCD7 | -1260 | 7532 |
| PELP1 | -1762 | 6681 |
| PES1 | -4180 | 225 |
| PHAX | 1113 | 2478 |
| PLRG1 | 1950 | 5683 |
| PNO1 | 3733 | 1463 |
| PNRC2 | 3771 | 3788 |
| POLDIP3 | -1379 | 1393 |
| POLR2A | 69 | -175 |
| POLR2B | 704 | 1497 |
| POLR2C | -3573 | 4506 |
| POLR2D | 1768 | 1352 |
| POLR2E | -4269 | 2995 |
| POLR2F | -4459 | 6542 |
| POLR2G | -4291 | 8051 |
| POLR2H | -4045 | 7582 |
| POLR2I | -4354 | 6360 |
| POLR2K | 2165 | 2463 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| POP1 | -3052 | 5094 |
| POP4 | -469 | 400 |
| POP5 | -3520 | 1299 |
| POP7 | -3716 | 3501 |
| PPIE | -156 | 6766 |
| PPIH | -3905 | 3653 |
| PPIL1 | -535 | -331 |
| PPIL3 | 835 | 6751 |
| PPIL4 | 4133 | 5702 |
| PPIL6 | 2380 | 1728 |
| PPP2CA | 206 | 7715 |
| PPP2R2A | 4512 | 545 |
| PPWD1 | 4158 | 5849 |
| PRCC | -3965 | 3954 |
| PRKCA | -1818 | 8000 |
| PRKCD | 1080 | 8196 |
| PRMT5 | -1428 | 1335 |
| PRPF19 | -4252 | 6603 |
| PRPF3 | 2548 | 5450 |
| PRPF31 | -4455 | 1114 |
| PRPF38A | 1416 | 3222 |
| PRPF40A | 4523 | -732 |
| PRPF6 | -1909 | 5842 |
| PRPF8 | -2874 | 2308 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTBP1 | -4191 | 1938 |
| PUF60 | -4502 | 1825 |
| PUS1 | -4217 | 3159 |
| PUS3 | 2230 | -794 |
| PUS7 | 862 | 1483 |
| PWP2 | -1048 | 3413 |
| QTRT1 | -4229 | 5448 |
| RAE1 | -413 | 710 |
| RAN | -1758 | 2287 |
| RANBP2 | 3159 | 4436 |
| RBM17 | -1800 | 125 |
| RBM28 | -26 | 5611 |
| RCL1 | -2105 | 7180 |
| RIOK1 | 560 | 7832 |
| RIOK2 | 3774 | 1639 |
| RIOK3 | 4416 | 2142 |
| RNGTT | 1034 | 1738 |
| RNMT | 3501 | 2751 |
| RNPC3 | 3598 | 5919 |
| RNPS1 | -2236 | 2194 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPP14 | 2365 | 6104 |
| RPP21 | -4132 | 6725 |
| RPP25 | -2129 | 7163 |
| RPP30 | 2696 | 4955 |
| RPP38 | 1524 | 1315 |
| RPP40 | 1358 | 2947 |
| RPPH1 | 1148 | 1756 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRP1 | 1700 | 4263 |
| RRP7A | -1919 | 3257 |
| RRP9 | -4264 | -254 |
| RTCB | 2529 | 419 |
| SART1 | -2359 | 485 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SENP3 | -1607 | 8082 |
| SET | -85 | 2256 |
| SF1 | -1066 | 3382 |
| SF3A1 | -2013 | 8163 |
| SF3A2 | -3065 | -385 |
| SF3A3 | -2587 | 4867 |
| SF3B2 | -2027 | 2407 |
| SF3B3 | -522 | 1897 |
| SF3B4 | -297 | 3562 |
| SF3B5 | -4440 | 6460 |
| SKIV2L | -864 | 5629 |
| SLBP | 504 | 6846 |
| SLU7 | 4001 | 1810 |
| SMG1 | 2219 | 8338 |
| SMG5 | -2243 | -216 |
| SMG6 | -2308 | -684 |
| SMG7 | 3207 | 3120 |
| SMG8 | 1402 | 8016 |
| SMNDC1 | 3320 | 7108 |
| SNRNP200 | -2948 | 4559 |
| SNRNP25 | -4363 | 1885 |
| SNRNP27 | 3031 | 3616 |
| SNRNP35 | 3385 | 3076 |
| SNRNP40 | -774 | 3657 |
| SNRNP48 | 4396 | -394 |
| SNRNP70 | -2648 | 5189 |
| SNRPA | -815 | 682 |
| SNRPA1 | 682 | 6087 |
| SNRPB | -3992 | 7621 |
| SNRPB2 | 2945 | 5813 |
| SNRPC | -2572 | 1748 |
| SNRPD1 | 1508 | 929 |
| SNRPD2 | -4651 | 415 |
| SNRPD3 | -1725 | 6820 |
| SNRPE | -2568 | 5874 |
| SNRPG | -72 | 6488 |
| SNRPN | -983 | -769 |
| SNU13 | -4216 | -644 |
| SNUPN | -1723 | 951 |
| SNW1 | 2996 | 3991 |
| SRRM1 | 4457 | 6158 |
| SRRM2 | 434 | -714 |
| SRRT | -2876 | 849 |
| SRSF10 | 2122 | 6891 |
| SRSF11 | 1727 | 7857 |
| SRSF2 | -2532 | 3260 |
| SRSF3 | 1847 | 187 |
| SRSF4 | 2281 | -519 |
| SRSF7 | 148 | 4766 |
| SRSF9 | -3616 | 8085 |
| SUPT5H | -2806 | 5377 |
| SYF2 | 2420 | 7318 |
| SYMPK | 2075 | 3609 |
| TBL3 | -3391 | 5281 |
| TEX10 | 3906 | -299 |
| TFB1M | 1711 | 2155 |
| TFIP11 | -2046 | 986 |
| THADA | 1146 | 5785 |
| THG1L | 1308 | 1011 |
| THOC1 | 3509 | 7153 |
| THOC5 | 72 | 4223 |
| THOC7 | 2924 | 3742 |
| THUMPD1 | 2892 | 1438 |
| TNFSF13 | -741 | 5429 |
| TNKS1BP1 | -3284 | 1210 |
| TNPO1 | 1166 | 4389 |
| TP53RK | -1870 | 6091 |
| TPR | 3600 | 5135 |
| TPRKB | 1483 | 6513 |
| TRDMT1 | 1932 | 1435 |
| TRIT1 | 1108 | 1371 |
| TRMT1 | -3869 | 1491 |
| TRMT10A | 2538 | -524 |
| TRMT11 | 3668 | 5312 |
| TRMT112 | -4628 | 7797 |
| TRMT12 | -2164 | -497 |
| TRMT44 | -1493 | -658 |
| TRMT6 | 1566 | 8220 |
| TRMT61A | -3453 | 4965 |
| TRMT61B | -610 | 4516 |
| TRMU | -1188 | 6881 |
| TRNT1 | 4016 | 1243 |
| TSEN15 | 2823 | 1035 |
| TSEN2 | -804 | 5815 |
| TSEN34 | -3047 | 7424 |
| TSEN54 | -3166 | 1406 |
| TSR1 | 936 | 6427 |
| TSR3 | -4599 | 1632 |
| TTC37 | 3377 | -69 |
| TXNL4A | -4343 | -317 |
| TYW1 | 1024 | 3716 |
| TYW3 | 1277 | 4002 |
| TYW5 | 3579 | 7704 |
| U2AF1 | 3909 | 6524 |
| U2AF1L4 | 2207 | -455 |
| U2AF2 | -4373 | 6409 |
| U2SURP | 4185 | 7973 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UPF1 | -2034 | 712 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
| URM1 | -4576 | 2783 |
| USP39 | -3115 | 3721 |
| UTP15 | 3847 | 2200 |
| UTP18 | 270 | 4533 |
| UTP20 | 2920 | 5003 |
| UTP3 | -2389 | 5911 |
| UTP6 | 2274 | 1898 |
| WBP11 | -749 | 1400 |
| WBP4 | 4348 | 7089 |
| WDR12 | 2057 | 2290 |
| WDR18 | -2633 | 2126 |
| WDR3 | -412 | 553 |
| WDR33 | -640 | 7078 |
| WDR36 | 2054 | 4917 |
| WDR43 | -603 | 2132 |
| WDR61 | 1731 | 2444 |
| WDR75 | 2858 | 3723 |
| WDR77 | -514 | -650 |
| WTAP | 1666 | 6017 |
| XAB2 | -2677 | 44 |
| XPO1 | 4316 | 5628 |
| XPOT | 3290 | -75 |
| XRN1 | 4448 | -176 |
| XRN2 | 248 | 2920 |
| YBX1 | -1603 | 4540 |
| YWHAB | 3845 | 4090 |
| YWHAZ | 2673 | 2738 |
| ZBTB8OS | 2969 | 4896 |
| ZCRB1 | 3332 | 2608 |
| ZFP36 | -3648 | -336 |
| ZFP36L1 | -2065 | 880 |
| ZMAT5 | -1075 | 1510 |
Developmental Biology
| metric | value |
|---|---|
| setSize | 450 |
| pMANOVA | 1.1e-06 |
| p.adjustMANOVA | 3.33e-05 |
| s.dist | 0.145 |
| s.RNA | -0.144 |
| s.meth | -0.0196 |
| p.RNA | 2.61e-07 |
| p.meth | 0.482 |
| Gene | RNA | meth |
|---|---|---|
| KRT10 | -4640 | -837 |
| RPS2 | -4667 | -712 |
| MAPK3 | -4654 | -479 |
| RPS23 | -4487 | -355 |
| RPS8 | -4077 | -349 |
| DOK2 | -2274 | -569 |
| LIMK1 | -1621 | -632 |
| NR6A1 | -2375 | -323 |
| PSMD9 | -4063 | -186 |
| RPL36 | -4617 | -158 |
| GIT1 | -4150 | -130 |
| SEMA3A | -623 | -798 |
| AJUBA | -567 | -835 |
| PKP4 | -1351 | -304 |
| CNTNAP1 | -721 | -564 |
| RPS6KA4 | -2770 | -121 |
| KMT2D | -343 | -326 |
| MAP2K1 | -710 | -148 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ABL1 | -2415 | 5977 |
| ABL2 | -629 | 4991 |
| ABLIM1 | -2783 | 4445 |
| ABLIM2 | -2867 | 7101 |
| ACTB | -398 | 4265 |
| ACTG1 | -3749 | 6428 |
| ACTR2 | 3409 | 4951 |
| ACTR3 | 1752 | 4499 |
| ACVR1B | 585 | 7504 |
| ACVR2A | 160 | 7271 |
| ADAM10 | 2774 | 3603 |
| ADAM11 | -928 | 49 |
| ADAM22 | -1125 | 4152 |
| AGAP2 | -3788 | 1611 |
| AGRN | 3968 | 3516 |
| AJUBA | -567 | -835 |
| AKT1 | -4019 | 4230 |
| AKT2 | -4353 | 3475 |
| ALCAM | -2738 | 465 |
| ANK1 | 185 | 253 |
| ANK3 | 1141 | -855 |
| AP2A1 | 143 | 1895 |
| AP2M1 | -4214 | 5734 |
| AP2S1 | -2753 | 3997 |
| APH1A | -4123 | 1663 |
| APH1B | 3961 | 2594 |
| ARHGAP35 | -3569 | 6432 |
| ARHGAP39 | -1168 | 8415 |
| ARHGEF12 | -421 | 8154 |
| ARHGEF7 | -2793 | 964 |
| ARPC1B | -2892 | 2843 |
| ARPC2 | 469 | 5703 |
| ARPC3 | 2190 | 4838 |
| ARPC5 | 2839 | 2343 |
| ASH2L | 2933 | 5772 |
| BNIP2 | 4040 | -571 |
| CACNA1C | -3748 | 3128 |
| CACNA1I | -1347 | 683 |
| CACNB3 | -1466 | 4217 |
| CAP1 | -498 | 5579 |
| CAPN1 | -2761 | 5491 |
| CAPNS1 | 304 | 6108 |
| CASC3 | -2347 | 3341 |
| CBFB | 2931 | 1473 |
| CCNC | 3430 | 2192 |
| CCND3 | -1137 | 2914 |
| CD72 | -4442 | 1306 |
| CDC42 | 3092 | 7063 |
| CDK19 | 326 | 749 |
| CDK2 | -1746 | 6577 |
| CDK4 | -4272 | 6700 |
| CDK5 | 767 | 4651 |
| CDK5R1 | -3813 | 7721 |
| CDK8 | 1880 | 2327 |
| CDKN1A | 2610 | 7579 |
| CDON | 45 | -268 |
| CEBPA | -1783 | 8110 |
| CEBPB | 37 | 2587 |
| CEBPD | -1956 | 1324 |
| CEBPE | 922 | 1051 |
| CFL1 | -3122 | 4075 |
| CHD9 | 2218 | 6134 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CLTA | -1596 | 1476 |
| CLTB | -4279 | 600 |
| CLTC | 355 | 2682 |
| CLTCL1 | -18 | 7791 |
| CNOT6 | 4054 | 6051 |
| CNTNAP1 | -721 | -564 |
| COL9A2 | 3330 | 1721 |
| CREB1 | 2778 | 5066 |
| CREBBP | -2371 | 6830 |
| CSNK2A2 | 1848 | 3957 |
| CSNK2B | -56 | 7503 |
| CTCF | 307 | 4700 |
| CTNNB1 | 555 | 6731 |
| CUL2 | 3543 | 6010 |
| CXCR4 | -1226 | 6685 |
| CYP51A1 | 3722 | 2962 |
| DAG1 | -899 | 2764 |
| DEK | 4279 | 4890 |
| DLG1 | 3070 | 5149 |
| DLG4 | -884 | 284 |
| DNM1 | 4341 | 2162 |
| DNM2 | -3538 | 6605 |
| DOK2 | -2274 | -569 |
| DOK4 | -4497 | 6128 |
| DPYSL2 | 3115 | 7422 |
| DRAP1 | 1361 | 615 |
| E2F1 | 2277 | 1130 |
| EED | 2485 | 2932 |
| EFNA3 | -2140 | 7466 |
| EFNA4 | -1649 | 7073 |
| EFNB2 | -2982 | 8212 |
| EGR2 | -521 | 5319 |
| EIF4A3 | -3302 | 5329 |
| EIF4G1 | -2084 | 3220 |
| EP300 | 1140 | 3364 |
| EPAS1 | 3726 | -699 |
| EPHA4 | -4265 | 6667 |
| EPHB6 | -4453 | 1026 |
| ERBB2 | -1287 | 7893 |
| ETF1 | 2978 | 7120 |
| EVL | -2192 | 3804 |
| EZH2 | 4525 | 4485 |
| EZR | 1057 | 5759 |
| FAM120B | 4324 | 7550 |
| FARP2 | 1855 | 1865 |
| FAU | -4597 | 5991 |
| FES | -2861 | 4123 |
| FLI1 | -1853 | 4363 |
| FOXO1 | -2772 | 821 |
| FOXO3 | -1552 | 7336 |
| FOXP1 | 388 | 2546 |
| FRS2 | 2770 | 165 |
| FURIN | -4427 | 8374 |
| FYN | -1416 | 2811 |
| GAB2 | 239 | 350 |
| GFI1 | 406 | 2432 |
| GIT1 | -4150 | -130 |
| GRB10 | 1083 | 192 |
| GRB2 | -584 | 5992 |
| GRIN1 | -2758 | 6304 |
| GSK3B | -53 | 3637 |
| GSPT1 | 3544 | 4369 |
| HDAC2 | 196 | 4593 |
| HDAC3 | -2003 | 8308 |
| HHEX | 3084 | 7494 |
| HMGCR | 675 | 4936 |
| HOXA1 | 3684 | 221 |
| HRAS | -3828 | 1490 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| IL6R | -496 | 6551 |
| IRS2 | -769 | 5305 |
| ITGA1 | 129 | 5574 |
| ITGA2 | 4549 | 4016 |
| ITGA5 | -3016 | 6926 |
| ITGAV | 2346 | 3287 |
| ITSN1 | 4322 | 5424 |
| JUN | -3439 | 2775 |
| KAT2A | -1943 | 2984 |
| KAT2B | 3786 | 630 |
| KLF5 | 4287 | 7603 |
| KMT2A | 770 | -502 |
| KMT2C | 2815 | 8449 |
| KMT2D | -343 | -326 |
| KRAS | 4217 | 4020 |
| KRT10 | -4640 | -837 |
| LAMA2 | -1833 | 5768 |
| LDB1 | -4282 | 4806 |
| LIMK1 | -1621 | -632 |
| LIMK2 | -1657 | 4617 |
| LYPLA2 | -4333 | 2325 |
| MAML1 | -2091 | 5639 |
| MAML2 | -4316 | 2218 |
| MAML3 | 673 | 8147 |
| MAP2K1 | -710 | -148 |
| MAP2K2 | -4596 | 8056 |
| MAP2K6 | 2412 | 2172 |
| MAPK1 | 300 | 2770 |
| MAPK14 | 586 | 2235 |
| MAPK3 | -4654 | -479 |
| MAPK7 | -556 | 3019 |
| MAPK8 | 1601 | 6176 |
| MBP | -2941 | 4049 |
| MED1 | -52 | 5989 |
| MED10 | -1769 | 437 |
| MED11 | -3627 | 2732 |
| MED13 | -328 | 6657 |
| MED13L | 2625 | 3819 |
| MED15 | 288 | 637 |
| MED16 | -3837 | 6781 |
| MED17 | 1192 | 1178 |
| MED18 | 328 | -582 |
| MED19 | 147 | 269 |
| MED20 | -2234 | 3815 |
| MED21 | 2760 | 7649 |
| MED22 | -4434 | 6196 |
| MED23 | 3063 | 2535 |
| MED24 | -2702 | 4354 |
| MED25 | -635 | 5856 |
| MED26 | -4239 | 4987 |
| MED27 | -992 | 2243 |
| MED28 | 2431 | 6056 |
| MED29 | -2864 | 3182 |
| MED30 | -2116 | 1820 |
| MED31 | 4278 | 8039 |
| MED4 | 2475 | 1156 |
| MED6 | 2901 | 7020 |
| MED7 | 2793 | 451 |
| MED8 | 996 | 5186 |
| MED9 | -1978 | 4035 |
| MEF2A | 3561 | 7468 |
| MEF2D | -3080 | 4570 |
| MPZ | -3160 | 5102 |
| MYB | 3651 | 533 |
| MYH10 | 2140 | 3825 |
| MYH9 | -2293 | 3393 |
| MYL12A | -320 | 3613 |
| MYL6 | -4267 | 4209 |
| MYO9B | -344 | 3151 |
| NAB1 | 4437 | 1502 |
| NAB2 | 265 | 3007 |
| NCBP1 | 4110 | 6545 |
| NCBP2 | 3626 | 3728 |
| NCK1 | 76 | 1103 |
| NCK2 | -3976 | 2464 |
| NCOA2 | 2216 | 7322 |
| NCOA3 | 3112 | 6898 |
| NCOA6 | 1494 | 761 |
| NCOR1 | 878 | 1101 |
| NCOR2 | -979 | 580 |
| NCSTN | 1936 | -457 |
| NEO1 | -3704 | 949 |
| NOTCH1 | -3404 | 2429 |
| NR6A1 | -2375 | -323 |
| NTN1 | -2541 | 8233 |
| NUMB | 2288 | 1647 |
| ONECUT1 | -841 | 6741 |
| PABPC1 | 1884 | 3737 |
| PAGR1 | -4657 | 6339 |
| PAK1 | 3662 | 4972 |
| PAK2 | 2849 | 2509 |
| PAK4 | -2690 | 779 |
| PAXIP1 | 1687 | 2299 |
| PDLIM7 | -472 | 142 |
| PFN1 | -3621 | 2497 |
| PFN2 | -1216 | 8232 |
| PIAS2 | 4238 | 6972 |
| PIK3CA | 2762 | 3290 |
| PIK3CD | -3743 | 153 |
| PIK3R1 | -1510 | 5157 |
| PIK3R2 | -2818 | 5365 |
| PIK3R3 | 3211 | 3533 |
| PIP5K1C | -2340 | 8050 |
| PITPNA | 1756 | 1699 |
| PKNOX1 | -27 | 7175 |
| PKP4 | -1351 | -304 |
| PLCG1 | -1509 | 5809 |
| PLXNA2 | -1457 | 4087 |
| PLXNC1 | 2018 | 1218 |
| PLXND1 | -479 | 6377 |
| PML | 4377 | 1165 |
| POLR2A | 69 | -175 |
| POLR2B | 704 | 1497 |
| POLR2C | -3573 | 4506 |
| POLR2D | 1768 | 1352 |
| POLR2E | -4269 | 2995 |
| POLR2F | -4459 | 6542 |
| POLR2G | -4291 | 8051 |
| POLR2H | -4045 | 7582 |
| POLR2I | -4354 | 6360 |
| POLR2K | 2165 | 2463 |
| PPP3CB | 3219 | 5276 |
| PRKACA | -456 | 3985 |
| PRKACB | -591 | 7740 |
| PRKAR2A | 717 | 532 |
| PRKCA | -1818 | 8000 |
| PRKCQ | -1062 | 3938 |
| PRNP | 197 | 861 |
| PSEN1 | 3287 | 1724 |
| PSEN2 | 607 | 4736 |
| PSENEN | -1847 | 5332 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTK2 | 498 | 2498 |
| PTPN11 | 942 | 3777 |
| PTPRA | -2832 | 5280 |
| PTPRC | 3675 | 1766 |
| RAC1 | 3104 | 7511 |
| RANBP9 | 94 | 4150 |
| RARA | 775 | 2140 |
| RARG | -1013 | 3360 |
| RASA1 | 4236 | 3050 |
| RBBP4 | 474 | 2574 |
| RBBP5 | 1706 | 5848 |
| RBPJ | 3410 | 3986 |
| RBX1 | 837 | 6226 |
| RELA | -2976 | 5749 |
| RHOA | 2017 | 1886 |
| RHOB | 2740 | 4751 |
| RND1 | 3392 | 344 |
| RNPS1 | -2236 | 2194 |
| ROCK1 | 4407 | 2216 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS6KA1 | -2059 | 6292 |
| RPS6KA2 | -1618 | 6457 |
| RPS6KA4 | -2770 | -121 |
| RPS6KA5 | 4395 | 7378 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRAS | 3221 | 4131 |
| RUNX1 | 4163 | 3270 |
| SDCBP | 1371 | 7446 |
| SEMA3A | -623 | -798 |
| SEMA4A | 2008 | -775 |
| SEMA4D | -1 | 721 |
| SEMA7A | -1480 | 4968 |
| SHC1 | 2869 | 7320 |
| SIAH1 | 157 | 5770 |
| SIAH2 | 3459 | 1878 |
| SLIT1 | -2335 | 4573 |
| SMAD2 | 3517 | 1116 |
| SMAD3 | -1583 | 5325 |
| SMAD4 | 3210 | 777 |
| SMARCA4 | -2205 | 2893 |
| SNW1 | 2996 | 3991 |
| SOS1 | 4239 | 3280 |
| SOS2 | 2856 | 87 |
| SPAG9 | 1747 | 1963 |
| SPI1 | 1048 | 3235 |
| SPTAN1 | -3370 | 372 |
| SPTBN1 | -3730 | 7757 |
| SPTBN5 | 191 | 2482 |
| SRC | 831 | -92 |
| SREBF1 | -1883 | 5382 |
| SREBF2 | -396 | 3407 |
| SRGAP1 | 4412 | 7388 |
| SRGAP3 | 3962 | 2145 |
| ST8SIA4 | 3866 | 3040 |
| STAT3 | 2390 | 7085 |
| STX1A | -1470 | 1045 |
| STX1B | 3179 | 865 |
| TBL1XR1 | 1388 | 1367 |
| TCF12 | 448 | -80 |
| TCF3 | -2834 | 3020 |
| TFDP1 | 3251 | 471 |
| TFDP2 | -3887 | 3770 |
| TGFB1 | -2920 | 4353 |
| TLN1 | -2005 | 2103 |
| TNF | 3390 | -678 |
| TRIO | -2384 | 8416 |
| TRPC1 | 2000 | 4764 |
| TSC22D1 | 1625 | 7169 |
| TYROBP | -1830 | 835 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UPF2 | 3964 | 4021 |
| UPF3A | -404 | 6410 |
| USP33 | 4320 | -215 |
| UTRN | 2424 | 460 |
| VASP | -1749 | 3426 |
| VAV2 | 1189 | 7727 |
| VAV3 | -2987 | 8297 |
| WASL | 2271 | 7402 |
| WDR5 | -2956 | 4719 |
| WNT1 | -940 | 7669 |
| YES1 | 842 | -624 |
| YY1 | -3999 | 2757 |
| ZNF335 | -488 | 2918 |
| ZNF638 | 4461 | 5958 |
| ZSWIM8 | -2563 | 4681 |
Metabolism
| metric | value |
|---|---|
| setSize | 1215 |
| pMANOVA | 1.29e-06 |
| p.adjustMANOVA | 3.81e-05 |
| s.dist | 0.0939 |
| s.RNA | -0.0877 |
| s.meth | 0.0336 |
| p.RNA | 7.76e-07 |
| p.meth | 0.0585 |
| Gene | RNA | meth |
|---|---|---|
| UQCR11 | -4517 | 8422 |
| MCAT | -4574 | 7952 |
| NDUFB2 | -4321 | 8398 |
| TRMT112 | -4628 | 7797 |
| RPS12 | -4648 | 7699 |
| RPL8 | -4633 | 7647 |
| APRT | -4610 | 7685 |
| RPL18 | -4572 | 7741 |
| B3GNT7 | -4439 | 7920 |
| NME4 | -4307 | 7769 |
| UCK1 | -4091 | 8037 |
| FPGS | -4127 | 7949 |
| ELOVL4 | -4209 | 7748 |
| ADCY9 | -3842 | 8419 |
| NDUFB1 | -4027 | 7880 |
| GALE | -3824 | 8229 |
| TSTD1 | -3692 | 8445 |
| RPL23A | -3954 | 7846 |
| NUDT1 | -4577 | 6754 |
| POR | -3789 | 8126 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| AACS | -1882 | 6880 |
| AANAT | 1895 | 7396 |
| ABCA1 | -1161 | 7256 |
| ABCC1 | 3018 | 1830 |
| ABCC5 | -2661 | 4067 |
| ABCD4 | -1561 | 5999 |
| ABHD10 | 3564 | -11 |
| ABHD14B | -3683 | 1280 |
| ABHD3 | 4131 | 4066 |
| ABHD4 | -3092 | 4788 |
| ABHD5 | 3763 | 725 |
| ACAA1 | -1942 | 6285 |
| ACACA | -1490 | 4853 |
| ACACB | 1239 | 5505 |
| ACAD10 | 2747 | 2202 |
| ACAD11 | 3902 | 2786 |
| ACADM | 3545 | 2050 |
| ACADS | -4167 | 3068 |
| ACADSB | 1775 | 8307 |
| ACAT1 | 2452 | 5751 |
| ACAT2 | -1337 | 2839 |
| ACBD4 | -1645 | 1771 |
| ACBD5 | 1043 | 6093 |
| ACBD6 | -3620 | 6484 |
| ACBD7 | 3164 | 6321 |
| ACER2 | -1504 | 662 |
| ACER3 | 3573 | 4478 |
| ACLY | 167 | 2355 |
| ACOT13 | 4004 | 3384 |
| ACOT7 | -2739 | 7608 |
| ACOT8 | -1880 | 3844 |
| ACOX1 | 2386 | 4680 |
| ACOX3 | -144 | 2168 |
| ACOXL | 3645 | -167 |
| ACP5 | -1311 | 4060 |
| ACP6 | -1927 | 6955 |
| ACSF2 | 3294 | 8270 |
| ACSF3 | -1868 | 4841 |
| ACSL1 | 953 | 4204 |
| ACSL3 | 2930 | 2017 |
| ACSL5 | 2233 | -554 |
| ACSL6 | -672 | -645 |
| ACSM1 | 844 | 7384 |
| ACSM3 | 493 | 7968 |
| ACSS1 | -4585 | 2746 |
| ACSS2 | 1377 | 4802 |
| ACY1 | -1004 | 4493 |
| ADA | -861 | 5136 |
| ADAL | 3716 | 6033 |
| ADCY4 | 2574 | 6234 |
| ADCY7 | -1481 | 2400 |
| ADCY9 | -3842 | 8419 |
| ADH5 | -4052 | 7584 |
| ADHFE1 | 2833 | 1107 |
| ADIPOR1 | 1702 | 5777 |
| ADIPOR2 | -1891 | 4928 |
| ADK | -929 | 4459 |
| ADO | -1163 | 6026 |
| ADPGK | 3143 | 2260 |
| ADSL | -2206 | 2551 |
| AFMID | 4331 | 1182 |
| AGK | 1734 | 6036 |
| AGL | 2761 | 2766 |
| AGMAT | 960 | 113 |
| AGPAT1 | -3146 | 6647 |
| AGPAT2 | -2979 | -330 |
| AGPAT3 | 3727 | -474 |
| AGPAT4 | 2172 | 5536 |
| AGPAT5 | 1088 | 2583 |
| AGPS | 3814 | 3792 |
| AGRN | 3968 | 3516 |
| AHCY | -4193 | 1896 |
| AHCYL1 | 1228 | 6911 |
| AHR | 435 | 397 |
| AHRR | -3855 | 791 |
| AIMP2 | 1455 | 6011 |
| AIP | -4462 | 1501 |
| AK2 | 796 | 3226 |
| AK9 | 1791 | -828 |
| AKR1A1 | -2022 | 4797 |
| AKR1B1 | -4550 | 2326 |
| AKR7A2 | -4559 | 6342 |
| AKT1 | -4019 | 4230 |
| ALAD | -3219 | 374 |
| ALDH18A1 | -2728 | 6062 |
| ALDH1B1 | -1325 | 7591 |
| ALDH3A2 | 3594 | 7674 |
| ALDH4A1 | -2260 | 3158 |
| ALDH6A1 | 636 | 335 |
| ALDH9A1 | 365 | 6692 |
| ALDOA | -1007 | 648 |
| ALDOC | -1052 | 7310 |
| ALOX5 | -19 | 6147 |
| ALOX5AP | -1559 | 3573 |
| AMACR | -1248 | 7571 |
| AMD1 | 3119 | 1679 |
| AMDHD1 | -1225 | 7850 |
| AMPD2 | -1775 | 6590 |
| AMPD3 | -2383 | 4571 |
| APRT | -4610 | 7685 |
| ARF1 | -3211 | 8404 |
| ARF3 | -3044 | 4378 |
| ARG2 | 1997 | 5936 |
| ARNT | 2384 | 5016 |
| ARNTL | -670 | 5761 |
| ARSA | 2241 | -585 |
| ARSB | 3191 | 6874 |
| ARSG | 3166 | 6628 |
| ARSK | -1874 | 5180 |
| ARV1 | 3707 | 8102 |
| ASAH1 | 3401 | 3500 |
| ASL | -813 | 7724 |
| ASNS | 1581 | 2242 |
| ASRGL1 | -1586 | 4268 |
| ATIC | -74 | 5012 |
| AUH | 806 | 1233 |
| AZIN1 | 1196 | 202 |
| AZIN2 | -1536 | 711 |
| B3GALT4 | -2967 | 5384 |
| B3GALT6 | -4007 | 7118 |
| B3GAT2 | -71 | 7818 |
| B3GAT3 | -4192 | 5844 |
| B3GNT2 | 3439 | 6205 |
| B3GNT7 | -4439 | 7920 |
| B4GALT1 | -1912 | 7957 |
| B4GALT2 | 223 | -162 |
| B4GALT3 | -318 | 2276 |
| B4GALT4 | 1590 | 4038 |
| B4GALT5 | 2064 | 5443 |
| B4GALT6 | -3063 | 5500 |
| B4GALT7 | -588 | 5460 |
| B4GAT1 | -4286 | 805 |
| BCAT1 | 2568 | 3114 |
| BCAT2 | -2441 | 2278 |
| BCKDHA | -3673 | 3276 |
| BCKDHB | 3030 | 1441 |
| BCKDK | -1667 | -102 |
| BDH1 | -1160 | 7874 |
| BDH2 | 1178 | 1524 |
| BLVRA | 4071 | 8206 |
| BLVRB | -3089 | 2113 |
| BPHL | 2360 | 4158 |
| BPNT1 | -2255 | -312 |
| BRIP1 | 3836 | 5492 |
| BSG | -3257 | 758 |
| BTD | -1444 | 3162 |
| CA13 | 1808 | 6746 |
| CA6 | 3405 | 407 |
| CACNA1C | -3748 | 3128 |
| CACNA2D2 | -1207 | -615 |
| CACNB3 | -1466 | 4217 |
| CAD | -1677 | 2219 |
| CALM1 | 1204 | 3996 |
| CARNMT1 | 1664 | 1640 |
| CARNS1 | 888 | 4453 |
| CAV1 | 531 | 7738 |
| CBR3 | -2768 | 6694 |
| CBR4 | 2657 | 7307 |
| CCNC | 3430 | 2192 |
| CD320 | -1923 | 1192 |
| CD38 | 3700 | 672 |
| CD44 | -732 | 4410 |
| CDIPT | -4471 | 1924 |
| CDK19 | 326 | 749 |
| CDK8 | 1880 | 2327 |
| CDS2 | -2877 | 5891 |
| CEPT1 | 3742 | 852 |
| CERK | -4526 | -373 |
| CERS5 | 3794 | 5437 |
| CERS6 | 789 | 4254 |
| CES2 | 332 | -738 |
| CHAC2 | -350 | 3031 |
| CHD9 | 2218 | 6134 |
| CHKA | 1741 | 6951 |
| CHKB | 583 | -26 |
| CHP1 | -348 | 624 |
| CHPF | -2139 | 5678 |
| CHPF2 | -3365 | 5473 |
| CHPT1 | 2500 | -368 |
| CHST11 | -2171 | 2817 |
| CHST12 | 1191 | 6327 |
| CHST14 | -3101 | 4687 |
| CHST2 | -3752 | 4950 |
| CHSY1 | 718 | 1619 |
| CIAO1 | -1350 | 5605 |
| CIAPIN1 | -2232 | 7962 |
| CKB | 393 | 6935 |
| CLOCK | 2899 | 6485 |
| CMBL | 3606 | 6744 |
| CMPK1 | -60 | 8216 |
| CNDP2 | 2264 | 4227 |
| COASY | -2461 | 984 |
| COMT | -2506 | -295 |
| COQ10A | -1505 | 7736 |
| COQ10B | 2581 | 5769 |
| COQ2 | 1968 | 3061 |
| COQ3 | -1282 | 3730 |
| COQ5 | 1892 | 3244 |
| COQ6 | 2523 | 3358 |
| COQ7 | 829 | 3334 |
| COQ9 | 745 | 4557 |
| COX10 | -276 | 4653 |
| COX11 | -354 | 3025 |
| COX14 | -3910 | 3855 |
| COX15 | 2919 | 2067 |
| COX16 | 3062 | 3560 |
| COX19 | 2555 | 298 |
| COX20 | 2719 | 3497 |
| COX4I1 | -3397 | 4535 |
| COX5A | -3147 | 3397 |
| COX5B | -3919 | -244 |
| COX6A1 | -4241 | 1809 |
| COX6B1 | -2878 | 2356 |
| COX6C | -3120 | 2408 |
| COX7A2L | -475 | 5803 |
| COX7C | -4162 | 603 |
| COX8A | -3761 | 3949 |
| CPNE1 | -4069 | 4825 |
| CPNE3 | 733 | 2510 |
| CPOX | -2807 | 6001 |
| CPS1 | 2640 | -256 |
| CPT1A | -504 | 24 |
| CPT2 | 3934 | 4055 |
| CPTP | -2303 | 8339 |
| CRAT | -2919 | 6522 |
| CREBBP | -2371 | 6830 |
| CRLS1 | 1122 | 3907 |
| CRYL1 | -1797 | 1437 |
| CRYM | -1784 | 4980 |
| CS | 1853 | 3697 |
| CSAD | 1599 | 3086 |
| CSGALNACT1 | -1614 | 1521 |
| CSGALNACT2 | 4409 | 323 |
| CSNK1G2 | -4070 | 6824 |
| CSNK2A2 | 1848 | 3957 |
| CSNK2B | -56 | 7503 |
| CTH | 2789 | 1184 |
| CTPS1 | 1268 | 2542 |
| CTSA | -803 | 2093 |
| CYB5A | 2825 | 5968 |
| CYB5B | 1770 | 3877 |
| CYB5R3 | -1430 | 4999 |
| CYC1 | -3658 | 5829 |
| CYCS | 2507 | 2450 |
| CYP2R1 | 3744 | 4409 |
| CYP2U1 | 2979 | 3610 |
| CYP46A1 | 4563 | 1277 |
| CYP4F22 | 4533 | -386 |
| CYP4V2 | -942 | 6671 |
| CYP51A1 | 3722 | 2962 |
| D2HGDH | 473 | 2389 |
| DBI | -4230 | 594 |
| DBT | 4481 | 1175 |
| DCK | -1622 | 4947 |
| DCTD | -530 | 3972 |
| DCTPP1 | -3525 | 3205 |
| DCXR | -1584 | 991 |
| DDAH2 | -3766 | 5773 |
| DDHD1 | 3086 | 8242 |
| DDHD2 | 1216 | 4728 |
| DECR1 | 4394 | 2646 |
| DECR2 | -441 | 4479 |
| DEGS1 | -1196 | 4801 |
| DERA | 3050 | 7436 |
| DGAT1 | -3285 | 6449 |
| DGAT2 | -2222 | 6848 |
| DGUOK | -459 | 7474 |
| DHCR24 | 3083 | 2371 |
| DHCR7 | -738 | 6464 |
| DHFR | 1251 | 224 |
| DHODH | -1409 | -456 |
| DHRS7B | 133 | 2471 |
| DHTKD1 | 4041 | 4620 |
| DLAT | 771 | 1054 |
| DLD | 3181 | 4527 |
| DLST | -3324 | 7228 |
| DNM2 | -3538 | 6605 |
| DPEP2 | 1477 | 5071 |
| DPYD | 623 | 1333 |
| DSE | -800 | 3771 |
| DSEL | 961 | 6534 |
| DTYMK | -2133 | 5494 |
| DUT | -3988 | 4927 |
| ECHS1 | -2544 | 4579 |
| ECI1 | -3694 | 5925 |
| ECI2 | 22 | 932 |
| ECSIT | -3251 | 6323 |
| EEF1E1 | -132 | 3266 |
| EEFSEC | -1276 | 6233 |
| EHHADH | 4258 | 8240 |
| ELOVL1 | -2245 | 8077 |
| ELOVL4 | -4209 | 7748 |
| ELOVL5 | 333 | 4258 |
| ELOVL6 | -2327 | 3278 |
| ENO1 | -1582 | 3952 |
| ENO2 | 848 | 5074 |
| ENO3 | -3118 | 8383 |
| ENOPH1 | -3863 | 4057 |
| ENPP2 | 3955 | 7490 |
| ENTPD1 | 2547 | 7155 |
| ENTPD4 | 1446 | 502 |
| ENTPD5 | 4264 | 3843 |
| ENTPD6 | -3644 | 4882 |
| ENTPD7 | 2166 | 5490 |
| EP300 | 1140 | 3364 |
| EPHX1 | -1382 | 7459 |
| EPHX2 | 442 | 2683 |
| ERCC2 | -2741 | 1785 |
| ESD | 1380 | 4779 |
| ESRRA | -1698 | 5928 |
| ESYT1 | -3007 | 4185 |
| ESYT2 | -3206 | 2998 |
| ETFA | 3562 | 5795 |
| ETFB | -2478 | 3419 |
| ETFDH | 3615 | 7626 |
| ETHE1 | -4327 | 804 |
| ETNK1 | 4506 | 7541 |
| EXT1 | 2751 | 7581 |
| EXT2 | -1857 | 7940 |
| FABP5 | 1173 | 3670 |
| FADS1 | 2877 | 7444 |
| FADS2 | 1234 | 4029 |
| FAH | -1191 | 526 |
| FAHD1 | -1355 | 2894 |
| FAM120B | 4324 | 7550 |
| FAR1 | 3894 | 4799 |
| FASN | -4024 | 3300 |
| FAU | -4597 | 5991 |
| FBP1 | 1378 | 6919 |
| FDFT1 | -3489 | 6829 |
| FDPS | -3734 | 3904 |
| FDX1 | 2724 | 5894 |
| FDXR | 2275 | 3311 |
| FECH | 993 | 1301 |
| FH | 78 | 1302 |
| FIG4 | 2861 | 5966 |
| FITM2 | -256 | 1675 |
| FLAD1 | -3470 | 7717 |
| FLVCR1 | 4538 | 7622 |
| FPGS | -4127 | 7949 |
| FUT10 | -1284 | 5277 |
| FUT11 | 1226 | 6318 |
| FUT4 | 626 | 5273 |
| FXN | -442 | 5459 |
| G6PC3 | -322 | 5378 |
| GAA | -1674 | 1089 |
| GALC | 1604 | 2777 |
| GALE | -3824 | 8229 |
| GALK1 | -2931 | 1849 |
| GALT | -907 | 3231 |
| GAPDH | -2978 | 1138 |
| GBA | -392 | 3514 |
| GBA2 | -1977 | 8316 |
| GCDH | -4665 | 937 |
| GCH1 | 4591 | 6722 |
| GCHFR | -4172 | 5217 |
| GCLC | 3643 | 2282 |
| GCLM | -1162 | 1772 |
| GCSH | 567 | 8071 |
| GDE1 | 877 | 7351 |
| GDPD1 | -759 | 4241 |
| GDPD5 | -116 | 4443 |
| GGCT | 3242 | 337 |
| GGPS1 | 4215 | 4472 |
| GGT1 | -2671 | -730 |
| GGT7 | -3530 | 7229 |
| GLB1 | 430 | 7211 |
| GLCE | -500 | 6213 |
| GLIPR1 | 2212 | 393 |
| GLO1 | 1137 | 1953 |
| GLRX | -391 | -480 |
| GLRX5 | -512 | 1567 |
| GLS | 3017 | 572 |
| GLTP | -1611 | 7934 |
| GLUD1 | 366 | 5206 |
| GLUL | 431 | 7319 |
| GLYCTK | -1495 | 6569 |
| GM2A | 2905 | 6425 |
| GMPR | 3867 | 2820 |
| GMPR2 | -3179 | 5774 |
| GMPS | 1278 | 7984 |
| GNA15 | -3885 | 7123 |
| GNAI2 | -1841 | 5421 |
| GNAQ | 2958 | 3831 |
| GNAS | -1888 | -276 |
| GNB1 | -1144 | -391 |
| GNB2 | -1967 | 6049 |
| GNB4 | 4237 | 8172 |
| GNB5 | -876 | 5796 |
| GNG2 | 237 | 4290 |
| GNG3 | 3973 | 8393 |
| GNG4 | 3231 | 7006 |
| GNG5 | 1165 | 3751 |
| GNG7 | -2766 | -475 |
| GNGT2 | -480 | -71 |
| GNPDA1 | -1526 | 2317 |
| GNPDA2 | 777 | 2466 |
| GNS | 2226 | 5474 |
| GOT1 | 1359 | 4943 |
| GOT2 | -1694 | 1040 |
| GPAM | 58 | 3283 |
| GPC2 | -2763 | 5692 |
| GPCPD1 | 3725 | 7416 |
| GPD1 | -541 | 2281 |
| GPD1L | -593 | 6949 |
| GPD2 | 3523 | 4786 |
| GPHN | -1400 | 7859 |
| GPI | -38 | 6596 |
| GPS2 | -1127 | 1242 |
| GPT2 | -744 | 6335 |
| GPX1 | -4030 | 2183 |
| GPX4 | -2407 | 5345 |
| GRHPR | -1777 | 1385 |
| GSR | -1273 | 1990 |
| GSS | -3126 | 7383 |
| GSTA4 | 4507 | 1574 |
| GSTK1 | 2409 | 1001 |
| GSTM3 | 2130 | 3582 |
| GSTM4 | 1802 | 4532 |
| GSTO1 | -298 | 7246 |
| GSTO2 | 325 | 3218 |
| GSTP1 | -2214 | 6832 |
| GSTZ1 | 2504 | 2248 |
| GUK1 | -2644 | 4350 |
| GUSB | -30 | 4887 |
| GYG1 | -1107 | 6468 |
| GYS1 | 222 | 4356 |
| HACD1 | 4171 | 8407 |
| HACD2 | -163 | 8176 |
| HACD3 | 543 | 8213 |
| HACD4 | 2688 | -111 |
| HACL1 | 1785 | 3208 |
| HADH | -2053 | 5854 |
| HADHA | -2825 | 7301 |
| HADHB | 1407 | 2687 |
| HAGH | -1616 | 5119 |
| HDAC3 | -2003 | 8308 |
| HEXA | -1960 | 6940 |
| HEXB | 389 | 7586 |
| HIBADH | 1941 | -309 |
| HIBCH | 3702 | 7161 |
| HILPDA | 1784 | 6194 |
| HK1 | -399 | 2185 |
| HK2 | -1834 | 1526 |
| HLCS | 1142 | 402 |
| HMBS | 192 | 5610 |
| HMGCL | 2614 | 477 |
| HMGCR | 675 | 4936 |
| HMGCS1 | 3436 | 7150 |
| HMMR | 1492 | 3599 |
| HMOX2 | -4484 | 704 |
| HPD | 4553 | 4383 |
| HPGD | 2708 | 8390 |
| HS3ST3B1 | -688 | 8081 |
| HS6ST1 | -2061 | 1462 |
| HSCB | -1441 | 7125 |
| HSD17B1 | -2715 | 953 |
| HSD17B11 | 1652 | 1203 |
| HSD17B12 | 640 | 2579 |
| HSD17B4 | 1220 | 2703 |
| HSD17B8 | -2009 | 1503 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| HYAL1 | 3627 | -580 |
| HYAL2 | -3375 | 2095 |
| HYAL3 | 1064 | 3787 |
| IDH1 | 3232 | 3293 |
| IDH2 | 894 | 8195 |
| IDH3A | 3970 | 236 |
| IDH3B | -2831 | 4119 |
| IDI1 | 2690 | 5283 |
| IDUA | -1810 | 7884 |
| IL4I1 | -1529 | -346 |
| IMPA1 | 3789 | 3575 |
| IMPA2 | -3639 | 4892 |
| IMPAD1 | 1626 | 2625 |
| IMPDH1 | -1093 | 6 |
| IMPDH2 | -4611 | 5354 |
| INPP1 | -403 | 4121 |
| INPP4A | -2191 | 2953 |
| INPP5A | -2590 | 773 |
| INPP5B | -16 | 5593 |
| INPP5D | -2063 | 1167 |
| INPP5E | -2254 | 6674 |
| INPP5F | 3505 | 500 |
| INPP5K | -338 | 5499 |
| INPPL1 | -1487 | 7291 |
| INSIG1 | 4521 | -623 |
| INSIG2 | 2479 | 4623 |
| IP6K1 | -3901 | 6478 |
| IP6K2 | -2836 | 7313 |
| IPMK | 3672 | 48 |
| IPPK | -1876 | 3195 |
| IQGAP1 | 236 | 375 |
| ISCA1 | -700 | 4007 |
| ISCU | -170 | -138 |
| ITPA | -2634 | 5915 |
| ITPK1 | -188 | 7094 |
| ITPKB | -4111 | 1876 |
| ITPKC | -1890 | 2812 |
| ITPR1 | -768 | 6634 |
| ITPR2 | 2201 | 4474 |
| ITPR3 | -742 | 2887 |
| IVD | -560 | 963 |
| KCNJ11 | 8 | -427 |
| KHK | -4010 | -50 |
| KMO | 2492 | 2433 |
| KPNB1 | 3511 | 5921 |
| L2HGDH | 3212 | 1163 |
| LBR | 657 | 84 |
| LCLAT1 | 2374 | 4627 |
| LDHA | 1649 | 7452 |
| LDHB | -2374 | 5282 |
| LDLR | 3793 | 3933 |
| LGMN | -2390 | 6394 |
| LHPP | -2104 | 676 |
| LIAS | 3516 | 6063 |
| LIPE | -2733 | 7854 |
| LIPT1 | 3406 | 7533 |
| LIPT2 | -2872 | 5908 |
| LMBRD1 | 2531 | 1143 |
| LPCAT1 | -2887 | -422 |
| LPCAT3 | -1496 | 2871 |
| LPCAT4 | -2157 | 3722 |
| LPGAT1 | 1959 | 4551 |
| LPIN1 | 1325 | 5878 |
| LPIN2 | 2176 | 5561 |
| LRP10 | -3062 | 1836 |
| LRP12 | -852 | 8362 |
| LRP8 | 582 | 2507 |
| LRPPRC | 651 | 376 |
| LSS | -2097 | 2493 |
| LTA4H | 1045 | 5719 |
| LTC4S | -4458 | 5108 |
| LYPLA1 | 3557 | 1207 |
| LYRM4 | -3714 | 766 |
| MAN2B1 | -2146 | 7279 |
| MAN2B2 | 2173 | 6921 |
| MAN2C1 | -152 | 4905 |
| MANBA | 3389 | 4780 |
| MAPKAPK2 | -3294 | 1423 |
| MAT2A | -2704 | 8062 |
| MAT2B | 2425 | 4880 |
| MBOAT1 | 3039 | 5227 |
| MBOAT7 | -1343 | 2661 |
| MBTPS1 | -277 | 2406 |
| MCAT | -4574 | 7952 |
| MCCC1 | 399 | 8183 |
| MCCC2 | 4355 | 5255 |
| MCEE | 1755 | 5597 |
| MDH1 | -326 | 5775 |
| MDH2 | -2903 | -832 |
| ME2 | 4386 | 1890 |
| ME3 | -3534 | 3966 |
| MECR | -2617 | 4523 |
| MED1 | -52 | 5989 |
| MED10 | -1769 | 437 |
| MED11 | -3627 | 2732 |
| MED13 | -328 | 6657 |
| MED13L | 2625 | 3819 |
| MED15 | 288 | 637 |
| MED16 | -3837 | 6781 |
| MED17 | 1192 | 1178 |
| MED18 | 328 | -582 |
| MED19 | 147 | 269 |
| MED20 | -2234 | 3815 |
| MED21 | 2760 | 7649 |
| MED22 | -4434 | 6196 |
| MED23 | 3063 | 2535 |
| MED24 | -2702 | 4354 |
| MED25 | -635 | 5856 |
| MED26 | -4239 | 4987 |
| MED27 | -992 | 2243 |
| MED28 | 2431 | 6056 |
| MED29 | -2864 | 3182 |
| MED30 | -2116 | 1820 |
| MED31 | 4278 | 8039 |
| MED4 | 2475 | 1156 |
| MED6 | 2901 | 7020 |
| MED7 | 2793 | 451 |
| MED8 | 996 | 5186 |
| MED9 | -1978 | 4035 |
| MFSD2A | -1500 | 2961 |
| MGST2 | -1058 | 7137 |
| MGST3 | 2808 | 494 |
| MINPP1 | 482 | 3856 |
| MLX | 414 | 6614 |
| MLYCD | 2573 | 6227 |
| MMAA | 4186 | 2913 |
| MMAB | -331 | 3567 |
| MMACHC | 1310 | -173 |
| MMADHC | 2143 | 4922 |
| MMS19 | -1697 | 4226 |
| MOCOS | 2376 | 2158 |
| MOCS2 | 1303 | 7896 |
| MOCS3 | -3512 | 842 |
| MORC2 | -1524 | 2368 |
| MPC2 | -3431 | 1469 |
| MPST | -4160 | 6640 |
| MSMO1 | 3980 | 4674 |
| MTAP | 1351 | 8057 |
| MTF1 | 3130 | 2958 |
| MTHFD1 | 169 | 732 |
| MTHFD1L | 3064 | 53 |
| MTHFD2 | 4070 | 7457 |
| MTHFR | 1320 | 7272 |
| MTHFS | -280 | 2616 |
| MTMR10 | 1876 | 8298 |
| MTMR12 | -161 | -115 |
| MTMR14 | -553 | 512 |
| MTMR2 | 801 | 7226 |
| MTMR3 | -892 | 255 |
| MTMR4 | 1798 | 4191 |
| MTMR6 | 3471 | 745 |
| MTMR9 | 3839 | 5025 |
| MTR | 1193 | 3011 |
| MTRR | 2720 | 5670 |
| MVD | -3549 | 8431 |
| MVK | 36 | 6710 |
| N6AMT1 | -1220 | 326 |
| NADK | 2096 | 5341 |
| NADK2 | 246 | -300 |
| NADSYN1 | -966 | 6645 |
| NAGLU | -3770 | 7426 |
| NAGS | -4298 | 5040 |
| NAMPT | 2144 | 5169 |
| NAPRT | 529 | -73 |
| NAT1 | 4364 | 6952 |
| NCOA2 | 2216 | 7322 |
| NCOA3 | 3112 | 6898 |
| NCOA6 | 1494 | 761 |
| NCOR1 | 878 | 1101 |
| NCOR2 | -979 | 580 |
| NDC1 | 131 | -274 |
| NDST2 | -1016 | -263 |
| NDUFA10 | -986 | 5793 |
| NDUFA11 | -2911 | 601 |
| NDUFA12 | -1521 | 729 |
| NDUFA13 | -4530 | 5091 |
| NDUFA2 | -4592 | 3313 |
| NDUFA3 | -3134 | 7304 |
| NDUFA4 | -3399 | 2018 |
| NDUFA5 | 3682 | 333 |
| NDUFA6 | -3137 | 4184 |
| NDUFA7 | -3111 | 2639 |
| NDUFA8 | 205 | 5072 |
| NDUFA9 | 3596 | 7361 |
| NDUFAB1 | -2963 | 1043 |
| NDUFAF1 | 1061 | 426 |
| NDUFAF2 | -606 | 2075 |
| NDUFAF3 | -3750 | 1824 |
| NDUFAF4 | -2177 | -161 |
| NDUFAF5 | 199 | -133 |
| NDUFAF6 | 2079 | -482 |
| NDUFB1 | -4027 | 7880 |
| NDUFB10 | -4425 | 4926 |
| NDUFB2 | -4321 | 8398 |
| NDUFB3 | -2008 | 5110 |
| NDUFB4 | -3151 | 1638 |
| NDUFB5 | 2559 | 3909 |
| NDUFB7 | -3940 | 4869 |
| NDUFB9 | -4113 | 4749 |
| NDUFC1 | -2413 | 2107 |
| NDUFC2 | -4064 | 5333 |
| NDUFS1 | 1302 | -31 |
| NDUFS2 | -2363 | 57 |
| NDUFS3 | -3256 | 193 |
| NDUFS4 | 1065 | 6272 |
| NDUFS5 | -3236 | 5637 |
| NDUFS6 | -4288 | 6204 |
| NDUFS7 | -3402 | 5729 |
| NDUFS8 | -3980 | 102 |
| NDUFV1 | -3895 | 4359 |
| NDUFV2 | 1839 | 1025 |
| NDUFV3 | 1256 | 6531 |
| NEU1 | 828 | 3069 |
| NEU3 | -2038 | 5695 |
| NFYA | -772 | 2644 |
| NFYB | 861 | 7873 |
| NFYC | 334 | 3129 |
| NHLRC1 | -3575 | 6568 |
| NME1 | -2681 | 790 |
| NME2 | -1247 | 1739 |
| NME3 | -4635 | 5035 |
| NME4 | -4307 | 7769 |
| NMNAT1 | -1503 | 4865 |
| NMNAT3 | -1501 | 5145 |
| NMRAL1 | -2809 | 6966 |
| NMRK1 | 2367 | -418 |
| NNT | 1982 | 7324 |
| NOS3 | -2361 | 4054 |
| NOSIP | -2607 | 358 |
| NQO1 | -2719 | 4198 |
| NQO2 | 1332 | 5302 |
| NR1D1 | -3780 | 5009 |
| NR1H2 | -2905 | 7088 |
| NR1H3 | -3599 | 8069 |
| NRF1 | -3757 | 6265 |
| NT5C | -3551 | 422 |
| NT5C2 | 4274 | 7558 |
| NT5C3A | 3619 | 488 |
| NT5M | -837 | 3412 |
| NUBP1 | -1990 | 2167 |
| NUBP2 | -4391 | 4755 |
| NUDT1 | -4577 | 6754 |
| NUDT12 | 2784 | 8286 |
| NUDT13 | 3597 | 931 |
| NUDT15 | 4072 | 3385 |
| NUDT16 | 1266 | 8333 |
| NUDT18 | -2029 | 7781 |
| NUDT19 | 1648 | 479 |
| NUDT3 | 290 | 1514 |
| NUDT4 | 2897 | 354 |
| NUDT5 | -1704 | 1778 |
| NUDT7 | 1246 | 4565 |
| NUDT9 | -1893 | 4255 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| OAT | 2059 | 329 |
| OAZ1 | -3109 | 6795 |
| OAZ2 | -681 | 7617 |
| OAZ3 | 402 | 3936 |
| ODC1 | 576 | 6387 |
| OGDH | 106 | 1499 |
| ORMDL1 | 3116 | 7689 |
| ORMDL3 | -1328 | 2581 |
| OSBP | 230 | 3085 |
| OSBPL2 | -324 | 3724 |
| OSBPL3 | -113 | 1671 |
| OSBPL5 | -1819 | 7435 |
| OSBPL7 | 68 | 1402 |
| OSBPL8 | 1134 | 6582 |
| OSBPL9 | 2005 | 3434 |
| OXCT1 | -236 | 3322 |
| PAICS | 1342 | 3791 |
| PANK1 | -289 | 391 |
| PANK2 | 2706 | 7498 |
| PANK3 | 1563 | 4242 |
| PANK4 | -3494 | 410 |
| PAOX | -3058 | -784 |
| PAPSS1 | 1440 | 6222 |
| PARP10 | 3622 | 249 |
| PARP14 | 4626 | 288 |
| PARP16 | -3690 | 3444 |
| PARP4 | 4357 | 2826 |
| PARP6 | -247 | 7359 |
| PARP8 | 1899 | -314 |
| PARP9 | 4644 | 3387 |
| PC | -3349 | 1255 |
| PCBD1 | -701 | 8417 |
| PCCB | -417 | 3538 |
| PCK2 | 3230 | 3678 |
| PCTP | 48 | 8320 |
| PCYT1A | 4138 | 5851 |
| PCYT2 | -3691 | 6152 |
| PDHB | 1458 | 6538 |
| PDHX | 998 | 5278 |
| PDK1 | 1567 | 4264 |
| PDK2 | -3851 | 5794 |
| PDP1 | 4082 | 7003 |
| PDP2 | 1106 | 1958 |
| PDPR | 2161 | 1098 |
| PDSS1 | 4078 | 1055 |
| PDSS2 | 2213 | -37 |
| PDXK | -1669 | 4973 |
| PECR | -3726 | 4694 |
| PEMT | -828 | 6770 |
| PEX11A | -2024 | 343 |
| PFAS | -4215 | 5204 |
| PFKFB2 | 2624 | 7652 |
| PFKFB3 | -718 | 5953 |
| PFKFB4 | 201 | 5420 |
| PFKL | -3383 | 23 |
| PFKM | -1733 | 6978 |
| PFKP | -581 | 246 |
| PGAM1 | -2900 | 1593 |
| PGD | -1631 | 4560 |
| PGLS | -4186 | 3410 |
| PGM1 | -3720 | 4577 |
| PGM2 | -2130 | 3355 |
| PGM2L1 | -1060 | 7574 |
| PGP | -4078 | 4732 |
| PGS1 | -3559 | 126 |
| PHGDH | 1399 | 6806 |
| PHKB | 3919 | 2 |
| PHKG2 | -902 | 748 |
| PHOSPHO1 | 1126 | 6821 |
| PHYKPL | 1656 | -693 |
| PI4K2A | -2814 | 524 |
| PI4K2B | 4624 | 2571 |
| PI4KA | -1385 | 4522 |
| PI4KB | 476 | 4394 |
| PIAS4 | -2609 | 7610 |
| PIK3CA | 2762 | 3290 |
| PIK3CD | -3743 | 153 |
| PIK3CG | 38 | 2565 |
| PIK3R1 | -1510 | 5157 |
| PIK3R2 | -2818 | 5365 |
| PIK3R3 | 3211 | 3533 |
| PIK3R4 | 795 | 2082 |
| PIK3R5 | -2368 | 1803 |
| PIKFYVE | 2456 | 428 |
| PIP4K2A | -2593 | 5449 |
| PIP4K2B | -3997 | 1209 |
| PIP4K2C | -704 | 5957 |
| PIP5K1A | -104 | 3950 |
| PIP5K1C | -2340 | 8050 |
| PISD | -1728 | -204 |
| PITPNB | 3307 | 4452 |
| PITPNM1 | -1527 | 98 |
| PITPNM2 | 154 | -196 |
| PITPNM3 | 1326 | 8239 |
| PKM | -1101 | 1481 |
| PLA2G12A | -222 | 7706 |
| PLA2G15 | -1632 | 3464 |
| PLA2G4C | -2947 | 1022 |
| PLA2G6 | -3311 | 2570 |
| PLB1 | -2603 | 2634 |
| PLCB2 | -1146 | 3659 |
| PLCB3 | -2386 | 6207 |
| PLCD1 | -2199 | 4941 |
| PLCD3 | -3488 | 5541 |
| PLCG1 | -1509 | 5809 |
| PLCG2 | -279 | 6178 |
| PLD1 | 3095 | 2196 |
| PLD3 | -1219 | 2245 |
| PLD6 | -2392 | 2922 |
| PLEKHA2 | -633 | 1920 |
| PLEKHA3 | 3167 | 8429 |
| PLEKHA6 | 2357 | 4193 |
| PLEKHA8 | 107 | 1512 |
| PLIN2 | -713 | 4612 |
| PLIN3 | -2400 | 4583 |
| PMVK | -2997 | 3761 |
| PNP | 88 | 2166 |
| PNPLA2 | -2805 | 8260 |
| PNPLA6 | -615 | 5863 |
| PNPLA7 | 95 | 2898 |
| PNPLA8 | 3225 | 6737 |
| PNPO | 1992 | 1278 |
| PODXL2 | -3807 | 5724 |
| POLD1 | -4148 | 753 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PON2 | -698 | 3937 |
| POR | -3789 | 8126 |
| PPA1 | 1609 | 5 |
| PPA2 | 2626 | 5436 |
| PPARD | -2942 | 4461 |
| PPARGC1B | 2477 | -746 |
| PPCDC | 2293 | 1709 |
| PPCS | 3222 | 2334 |
| PPIP5K2 | 3901 | 5913 |
| PPM1K | 4474 | 3255 |
| PPM1L | -2429 | 3626 |
| PPOX | -3078 | 6218 |
| PPP1CA | -3325 | 1926 |
| PPP1CB | 3653 | -226 |
| PPP1CC | 4003 | 3213 |
| PPP2CA | 206 | 7715 |
| PPP2CB | 1868 | 15 |
| PPP2R1B | 2025 | 612 |
| PPP2R5D | -1935 | 5740 |
| PPT1 | 2656 | 3100 |
| PPT2 | -3576 | 1907 |
| PRKAB2 | -58 | 4064 |
| PRKACA | -456 | 3985 |
| PRKACB | -591 | 7740 |
| PRKAG2 | 4195 | 5997 |
| PRKAR1A | 1757 | 3914 |
| PRKAR1B | -2636 | -687 |
| PRKAR2A | 717 | 532 |
| PRKCA | -1818 | 8000 |
| PRKD2 | 1133 | 6896 |
| PSAP | 1856 | 1290 |
| PSAT1 | 3574 | 3577 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PSPH | 634 | 5960 |
| PSTK | 687 | 7792 |
| PTDSS2 | -3316 | 268 |
| PTEN | 2561 | 3667 |
| PTGES2 | -3567 | -437 |
| PTGES3 | 2915 | 2735 |
| PTGR1 | 3081 | 7941 |
| PTGR2 | 905 | 3004 |
| PTPMT1 | 457 | 6661 |
| PTPN13 | -3587 | 8368 |
| PTS | 2885 | 7876 |
| PXMP2 | -1249 | 1966 |
| PYCR2 | -4652 | 1819 |
| PYGB | -3548 | -230 |
| QDPR | 3288 | 154 |
| QPRT | 3091 | -863 |
| RAB14 | 3204 | 1868 |
| RAB4A | -2360 | 2862 |
| RAB5A | 3918 | 1760 |
| RAE1 | -413 | 710 |
| RAN | -1758 | 2287 |
| RANBP2 | 3159 | 4436 |
| RAP1A | 3831 | 2618 |
| RDH11 | 2837 | 3749 |
| RETSAT | 296 | 6236 |
| RFK | 3154 | 6964 |
| RGL1 | 3442 | 941 |
| RIMKLB | -1456 | 7026 |
| RNLS | -786 | 3150 |
| RORA | -503 | 7068 |
| RPE | 1557 | 4886 |
| RPL10A | -3906 | 3614 |
| RPL11 | -4133 | 4777 |
| RPL13 | -3592 | 2572 |
| RPL13A | -4189 | 1453 |
| RPL14 | -4606 | 1652 |
| RPL15 | -4483 | 2869 |
| RPL17 | -4446 | 1601 |
| RPL18 | -4572 | 7741 |
| RPL18A | -4578 | 756 |
| RPL22 | -4226 | 5694 |
| RPL23 | -4320 | 5721 |
| RPL23A | -3954 | 7846 |
| RPL26 | -4430 | 4874 |
| RPL26L1 | -3094 | 2114 |
| RPL27A | -4586 | 5331 |
| RPL28 | -2755 | 2136 |
| RPL29 | -4627 | 4940 |
| RPL3 | -4614 | 363 |
| RPL31 | -4623 | 498 |
| RPL32 | -4475 | 4794 |
| RPL34 | -3852 | 913 |
| RPL35 | -4050 | 2921 |
| RPL36 | -4617 | -158 |
| RPL36AL | -4228 | 7261 |
| RPL37 | -4671 | 3446 |
| RPL37A | -4608 | 1854 |
| RPL38 | -4626 | 4360 |
| RPL39L | -3312 | 4235 |
| RPL4 | -4075 | 1004 |
| RPL41 | -4573 | 4810 |
| RPL6 | -2632 | 3365 |
| RPL7 | -4465 | 5023 |
| RPL8 | -4633 | 7647 |
| RPL9 | -3497 | 4325 |
| RPLP0 | -4589 | 5098 |
| RPLP1 | -4638 | 4276 |
| RPLP2 | -4668 | 3699 |
| RPS10 | -4643 | 2364 |
| RPS11 | -4631 | 1206 |
| RPS12 | -4648 | 7699 |
| RPS15 | -4287 | 1906 |
| RPS15A | -4595 | 1664 |
| RPS16 | -4603 | 4287 |
| RPS18 | -4365 | 4827 |
| RPS19 | -4416 | 1409 |
| RPS2 | -4667 | -712 |
| RPS20 | -4047 | 4760 |
| RPS23 | -4487 | -355 |
| RPS24 | -2612 | 6177 |
| RPS25 | -4499 | 139 |
| RPS26 | -641 | 6119 |
| RPS27A | -4637 | 2492 |
| RPS27L | 3375 | 2937 |
| RPS28 | -4598 | 17 |
| RPS29 | -4664 | 3935 |
| RPS3 | -4636 | 4069 |
| RPS3A | -3201 | 4040 |
| RPS5 | -4583 | 3327 |
| RPS6 | -4445 | 4750 |
| RPS7 | -4375 | 3942 |
| RPS8 | -4077 | -349 |
| RPS9 | -4100 | 1947 |
| RPSA | -733 | 692 |
| RRM1 | 1906 | 4009 |
| RRM2 | 1384 | 5483 |
| RRM2B | 3985 | 3044 |
| RTEL1 | -574 | 3440 |
| RUFY1 | -249 | 1443 |
| SACM1L | 1104 | 4322 |
| SAMD8 | 3767 | 4000 |
| SAMHD1 | 3588 | 7360 |
| SAR1B | 4493 | 8006 |
| SARDH | -3617 | 8313 |
| SBF1 | -2472 | 5826 |
| SC5D | 4028 | 5876 |
| SCAP | -3292 | 618 |
| SCD | 3670 | 4092 |
| SCLY | -1972 | 681 |
| SCO1 | 699 | 2221 |
| SCO2 | 2800 | 237 |
| SCP2 | 2208 | 8334 |
| SDC4 | -888 | 2476 |
| SDHA | -1305 | 6868 |
| SDHB | -20 | 3928 |
| SDHC | -4039 | 4014 |
| SEC13 | -2746 | 7357 |
| SEC23A | 2468 | 6291 |
| SEC24A | 3431 | 2029 |
| SEC24B | 2709 | 7049 |
| SEC24C | -1765 | 909 |
| SEC24D | 3056 | 6676 |
| SEH1L | 2536 | 6644 |
| SEPHS2 | -3131 | 4134 |
| SERINC1 | 2382 | 307 |
| SERINC3 | 554 | 2970 |
| SERINC4 | 2341 | -52 |
| SERINC5 | -1307 | 3136 |
| SGMS1 | 797 | 6179 |
| SGPL1 | 91 | -159 |
| SGPP1 | 3743 | 3679 |
| SHMT1 | 1176 | 4297 |
| SHMT2 | -1855 | 793 |
| SHPK | -1104 | 6422 |
| SIN3A | -1633 | 1529 |
| SIN3B | 541 | -271 |
| SLC16A1 | 2383 | 3079 |
| SLC16A3 | -1871 | 2641 |
| SLC19A1 | -3674 | 8356 |
| SLC19A2 | 740 | 6918 |
| SLC22A5 | -3222 | 8258 |
| SLC23A1 | 2450 | 1930 |
| SLC25A1 | -3072 | 4305 |
| SLC25A11 | -3288 | 3449 |
| SLC25A12 | 893 | 2412 |
| SLC25A13 | 1243 | 7294 |
| SLC25A15 | -2437 | 1269 |
| SLC25A16 | 3977 | 3858 |
| SLC25A17 | -607 | 2283 |
| SLC25A19 | -1647 | 3956 |
| SLC25A20 | -930 | 3425 |
| SLC25A28 | 2963 | 3263 |
| SLC25A32 | 4125 | 1396 |
| SLC25A37 | -171 | 870 |
| SLC25A44 | 945 | 5950 |
| SLC26A2 | -464 | 7114 |
| SLC27A1 | -4083 | 7218 |
| SLC27A2 | 4268 | 3284 |
| SLC27A3 | -95 | -468 |
| SLC27A5 | -1177 | -515 |
| SLC2A1 | -2643 | 2227 |
| SLC2A3 | -1308 | 4149 |
| SLC35B2 | -4008 | 3060 |
| SLC35B3 | 2139 | 875 |
| SLC35D1 | -2697 | 8003 |
| SLC36A4 | 3940 | 1392 |
| SLC37A1 | 409 | -635 |
| SLC37A2 | -1154 | 6125 |
| SLC37A4 | -1610 | 2578 |
| SLC3A2 | -2240 | 497 |
| SLC44A1 | 1642 | 3793 |
| SLC44A2 | -3174 | 1456 |
| SLC5A5 | 868 | 1265 |
| SLC5A6 | -1665 | 7996 |
| SLC7A5 | 846 | -652 |
| SLC9A1 | -569 | 996 |
| SMPD1 | -4021 | 5398 |
| SMPD2 | -4621 | 6627 |
| SMPD3 | -97 | 700 |
| SORD | -1041 | 4528 |
| SP1 | -1469 | 2146 |
| SPHK2 | -3681 | 6536 |
| SPTLC1 | 3139 | 5902 |
| SPTLC2 | 3378 | 7826 |
| SPTLC3 | 4247 | 822 |
| SPTSSA | 2381 | 8188 |
| SQLE | 2813 | 5917 |
| SRD5A1 | 3280 | 6836 |
| SRD5A3 | 2965 | 2425 |
| SREBF1 | -1883 | 5382 |
| SREBF2 | -396 | 3407 |
| SRM | -3117 | 3333 |
| ST3GAL1 | -2856 | 5875 |
| ST3GAL2 | -2835 | 2056 |
| ST3GAL3 | -2285 | 3508 |
| ST3GAL4 | -3883 | 2599 |
| ST3GAL6 | 3123 | 8424 |
| ST6GALNAC6 | -1502 | -547 |
| STARD10 | -3803 | 6296 |
| STARD3 | -4444 | 5403 |
| STARD3NL | -226 | 1126 |
| STARD4 | 4246 | 3269 |
| STARD5 | -4033 | 642 |
| STARD7 | 2400 | 6875 |
| STK11 | -4054 | 2662 |
| STX1A | -1470 | 1045 |
| STXBP1 | -2954 | 8426 |
| SUCLA2 | 1670 | 4105 |
| SUCLG1 | -422 | 6785 |
| SUCLG2 | 2310 | 5852 |
| SUMF1 | 29 | 2160 |
| SUMF2 | 575 | 105 |
| SURF1 | -1087 | 4051 |
| SYNJ1 | 4575 | 7298 |
| SYNJ2 | -3006 | 2797 |
| SYT5 | 3936 | 5940 |
| TACO1 | -4563 | 1969 |
| TALDO1 | -891 | 2955 |
| TBL1XR1 | 1388 | 1367 |
| TBXAS1 | 1699 | 8065 |
| TECR | -3187 | 7050 |
| THEM4 | -1553 | 8325 |
| THTPA | -3171 | 5912 |
| TIAM2 | 3223 | 7191 |
| TK1 | 338 | -581 |
| TK2 | 203 | 3463 |
| TKT | -2673 | 1831 |
| TM7SF2 | -4139 | 1418 |
| TMEM126B | 2113 | 440 |
| TNFAIP8 | -1745 | 1289 |
| TNFAIP8L1 | -4036 | 588 |
| TNFAIP8L2 | -3233 | 5776 |
| TPI1 | -1844 | 6828 |
| TPK1 | 3238 | 4576 |
| TPMT | 4010 | -286 |
| TPR | 3600 | 5135 |
| TPST1 | 1286 | 6863 |
| TPST2 | -3846 | 3734 |
| TRAP1 | -2023 | 6777 |
| TRIB3 | 1743 | 563 |
| TRMT112 | -4628 | 7797 |
| TSPO | -2933 | 8436 |
| TST | -3953 | -727 |
| TSTD1 | -3692 | 8445 |
| TXN | 345 | 339 |
| TXN2 | -4066 | 5130 |
| TXNRD1 | -851 | 214 |
| TYMP | 4406 | 930 |
| TYMS | 2305 | 3871 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2I | -2449 | 3654 |
| UBIAD1 | -3601 | 7597 |
| UCK1 | -4091 | 8037 |
| UCK2 | -4384 | 1044 |
| UCKL1 | -1028 | 7369 |
| UCP2 | -999 | 6416 |
| UGCG | 3270 | -30 |
| UGDH | 1394 | 4964 |
| UGP2 | 3623 | 2171 |
| UPP1 | 1285 | 487 |
| UQCR11 | -4517 | 8422 |
| UQCRB | -2167 | 1779 |
| UQCRC1 | -1772 | 5054 |
| UQCRC2 | 853 | 6364 |
| UQCRFS1 | 668 | 5771 |
| UQCRH | -4335 | 652 |
| UQCRQ | -3445 | 4201 |
| UROD | -4426 | 3279 |
| UROS | 2914 | 4994 |
| UST | -4544 | 6034 |
| VAC14 | -1569 | 2868 |
| VAMP2 | -1376 | 536 |
| VAPA | 1695 | 3839 |
| VAPB | 2145 | 8226 |
| VDAC1 | 2295 | 7841 |
| VDR | 3469 | 2694 |
| VKORC1 | -2700 | 6808 |
| WASL | 2271 | 7402 |
| XYLB | 1632 | 2353 |
| XYLT1 | -3718 | 4457 |
| XYLT2 | -3108 | 2519 |
| ZDHHC21 | 1039 | 2897 |
Respiratory electron transport
| metric | value |
|---|---|
| setSize | 79 |
| pMANOVA | 2.13e-06 |
| p.adjustMANOVA | 6.15e-05 |
| s.dist | 0.33 |
| s.RNA | -0.326 |
| s.meth | -0.0506 |
| p.RNA | 5.58e-07 |
| p.meth | 0.438 |
| Gene | RNA | meth |
|---|---|---|
| COX5B | -3919 | -244 |
| NDUFAF4 | -2177 | -161 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| COQ10A | -1505 | 7736 |
| COQ10B | 2581 | 5769 |
| COX11 | -354 | 3025 |
| COX14 | -3910 | 3855 |
| COX16 | 3062 | 3560 |
| COX19 | 2555 | 298 |
| COX20 | 2719 | 3497 |
| COX4I1 | -3397 | 4535 |
| COX5A | -3147 | 3397 |
| COX5B | -3919 | -244 |
| COX6A1 | -4241 | 1809 |
| COX6B1 | -2878 | 2356 |
| COX6C | -3120 | 2408 |
| COX7A2L | -475 | 5803 |
| COX7C | -4162 | 603 |
| COX8A | -3761 | 3949 |
| CYC1 | -3658 | 5829 |
| CYCS | 2507 | 2450 |
| ECSIT | -3251 | 6323 |
| ETFA | 3562 | 5795 |
| ETFB | -2478 | 3419 |
| ETFDH | 3615 | 7626 |
| LRPPRC | 651 | 376 |
| NDUFA10 | -986 | 5793 |
| NDUFA11 | -2911 | 601 |
| NDUFA12 | -1521 | 729 |
| NDUFA13 | -4530 | 5091 |
| NDUFA2 | -4592 | 3313 |
| NDUFA3 | -3134 | 7304 |
| NDUFA4 | -3399 | 2018 |
| NDUFA5 | 3682 | 333 |
| NDUFA6 | -3137 | 4184 |
| NDUFA7 | -3111 | 2639 |
| NDUFA8 | 205 | 5072 |
| NDUFA9 | 3596 | 7361 |
| NDUFAB1 | -2963 | 1043 |
| NDUFAF1 | 1061 | 426 |
| NDUFAF2 | -606 | 2075 |
| NDUFAF3 | -3750 | 1824 |
| NDUFAF4 | -2177 | -161 |
| NDUFAF5 | 199 | -133 |
| NDUFAF6 | 2079 | -482 |
| NDUFB1 | -4027 | 7880 |
| NDUFB10 | -4425 | 4926 |
| NDUFB2 | -4321 | 8398 |
| NDUFB3 | -2008 | 5110 |
| NDUFB4 | -3151 | 1638 |
| NDUFB5 | 2559 | 3909 |
| NDUFB7 | -3940 | 4869 |
| NDUFB9 | -4113 | 4749 |
| NDUFC1 | -2413 | 2107 |
| NDUFC2 | -4064 | 5333 |
| NDUFS1 | 1302 | -31 |
| NDUFS2 | -2363 | 57 |
| NDUFS3 | -3256 | 193 |
| NDUFS4 | 1065 | 6272 |
| NDUFS5 | -3236 | 5637 |
| NDUFS6 | -4288 | 6204 |
| NDUFS7 | -3402 | 5729 |
| NDUFS8 | -3980 | 102 |
| NDUFV1 | -3895 | 4359 |
| NDUFV2 | 1839 | 1025 |
| NDUFV3 | 1256 | 6531 |
| SCO1 | 699 | 2221 |
| SCO2 | 2800 | 237 |
| SDHA | -1305 | 6868 |
| SDHB | -20 | 3928 |
| SDHC | -4039 | 4014 |
| SURF1 | -1087 | 4051 |
| TACO1 | -4563 | 1969 |
| TMEM126B | 2113 | 440 |
| TRAP1 | -2023 | 6777 |
| UQCR11 | -4517 | 8422 |
| UQCRB | -2167 | 1779 |
| UQCRC1 | -1772 | 5054 |
| UQCRC2 | 853 | 6364 |
| UQCRFS1 | 668 | 5771 |
| UQCRH | -4335 | 652 |
| UQCRQ | -3445 | 4201 |
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
| metric | value |
|---|---|
| setSize | 80 |
| pMANOVA | 2.27e-06 |
| p.adjustMANOVA | 6.37e-05 |
| s.dist | 0.328 |
| s.RNA | -0.325 |
| s.meth | -0.0428 |
| p.RNA | 5.29e-07 |
| p.meth | 0.509 |
| Gene | RNA | meth |
|---|---|---|
| COX5B | -3919 | -244 |
| NDUFAF4 | -2177 | -161 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| COQ10A | -1505 | 7736 |
| COQ10B | 2581 | 5769 |
| COX11 | -354 | 3025 |
| COX14 | -3910 | 3855 |
| COX16 | 3062 | 3560 |
| COX19 | 2555 | 298 |
| COX20 | 2719 | 3497 |
| COX4I1 | -3397 | 4535 |
| COX5A | -3147 | 3397 |
| COX5B | -3919 | -244 |
| COX6A1 | -4241 | 1809 |
| COX6B1 | -2878 | 2356 |
| COX6C | -3120 | 2408 |
| COX7A2L | -475 | 5803 |
| COX7C | -4162 | 603 |
| COX8A | -3761 | 3949 |
| CYC1 | -3658 | 5829 |
| CYCS | 2507 | 2450 |
| ECSIT | -3251 | 6323 |
| ETFA | 3562 | 5795 |
| ETFB | -2478 | 3419 |
| ETFDH | 3615 | 7626 |
| LRPPRC | 651 | 376 |
| NDUFA10 | -986 | 5793 |
| NDUFA11 | -2911 | 601 |
| NDUFA12 | -1521 | 729 |
| NDUFA13 | -4530 | 5091 |
| NDUFA2 | -4592 | 3313 |
| NDUFA3 | -3134 | 7304 |
| NDUFA4 | -3399 | 2018 |
| NDUFA5 | 3682 | 333 |
| NDUFA6 | -3137 | 4184 |
| NDUFA7 | -3111 | 2639 |
| NDUFA8 | 205 | 5072 |
| NDUFA9 | 3596 | 7361 |
| NDUFAB1 | -2963 | 1043 |
| NDUFAF1 | 1061 | 426 |
| NDUFAF2 | -606 | 2075 |
| NDUFAF3 | -3750 | 1824 |
| NDUFAF4 | -2177 | -161 |
| NDUFAF5 | 199 | -133 |
| NDUFAF6 | 2079 | -482 |
| NDUFB1 | -4027 | 7880 |
| NDUFB10 | -4425 | 4926 |
| NDUFB2 | -4321 | 8398 |
| NDUFB3 | -2008 | 5110 |
| NDUFB4 | -3151 | 1638 |
| NDUFB5 | 2559 | 3909 |
| NDUFB7 | -3940 | 4869 |
| NDUFB9 | -4113 | 4749 |
| NDUFC1 | -2413 | 2107 |
| NDUFC2 | -4064 | 5333 |
| NDUFS1 | 1302 | -31 |
| NDUFS2 | -2363 | 57 |
| NDUFS3 | -3256 | 193 |
| NDUFS4 | 1065 | 6272 |
| NDUFS5 | -3236 | 5637 |
| NDUFS6 | -4288 | 6204 |
| NDUFS7 | -3402 | 5729 |
| NDUFS8 | -3980 | 102 |
| NDUFV1 | -3895 | 4359 |
| NDUFV2 | 1839 | 1025 |
| NDUFV3 | 1256 | 6531 |
| SCO1 | 699 | 2221 |
| SCO2 | 2800 | 237 |
| SDHA | -1305 | 6868 |
| SDHB | -20 | 3928 |
| SDHC | -4039 | 4014 |
| SURF1 | -1087 | 4051 |
| TACO1 | -4563 | 1969 |
| TMEM126B | 2113 | 440 |
| TRAP1 | -2023 | 6777 |
| UCP2 | -999 | 6416 |
| UQCR11 | -4517 | 8422 |
| UQCRB | -2167 | 1779 |
| UQCRC1 | -1772 | 5054 |
| UQCRC2 | 853 | 6364 |
| UQCRFS1 | 668 | 5771 |
| UQCRH | -4335 | 652 |
| UQCRQ | -3445 | 4201 |
Interferon alpha/beta signaling
| metric | value |
|---|---|
| setSize | 49 |
| pMANOVA | 2.39e-06 |
| p.adjustMANOVA | 6.43e-05 |
| s.dist | 0.425 |
| s.RNA | 0.413 |
| s.meth | -0.099 |
| p.RNA | 5.75e-07 |
| p.meth | 0.231 |
| Gene | RNA | meth |
|---|---|---|
| ISG15 | 4539 | -542 |
| BST2 | 3234 | -711 |
| USP18 | 4630 | -387 |
| MX2 | 4636 | -241 |
| IFIT2 | 4559 | -227 |
| OAS1 | 4608 | -193 |
| PTPN1 | 1532 | -296 |
| ISG20 | 3220 | -116 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ABCE1 | 2436 | 2902 |
| ADAR | 4354 | 5945 |
| BST2 | 3234 | -711 |
| EGR1 | -1941 | 7109 |
| HLA-A | -4490 | 2274 |
| HLA-B | -333 | 513 |
| HLA-C | -168 | 6790 |
| HLA-E | -1262 | 3744 |
| HLA-F | -4367 | -24 |
| HLA-H | -4088 | 7849 |
| IFI35 | 4496 | 208 |
| IFI6 | 4580 | 920 |
| IFIT1 | 4635 | 25 |
| IFIT2 | 4559 | -227 |
| IFIT3 | 4641 | 7117 |
| IFIT5 | 4531 | 7258 |
| IFITM1 | 2245 | 818 |
| IFNAR1 | 1797 | 6059 |
| IFNAR2 | -1405 | 1950 |
| IP6K2 | -2836 | 7313 |
| IRF1 | 3500 | 5454 |
| IRF2 | 3001 | 5323 |
| IRF3 | -2843 | 2803 |
| IRF4 | 3107 | 4603 |
| IRF5 | 87 | 8203 |
| IRF7 | 4358 | 6617 |
| IRF9 | 4504 | 5128 |
| ISG15 | 4539 | -542 |
| ISG20 | 3220 | -116 |
| JAK1 | -3728 | 6986 |
| MX1 | 4607 | 1151 |
| MX2 | 4636 | -241 |
| OAS1 | 4608 | -193 |
| OAS2 | 4638 | 3133 |
| OAS3 | 4612 | 5423 |
| OASL | 4547 | 6420 |
| PSMB8 | 957 | 1753 |
| PTPN1 | 1532 | -296 |
| PTPN11 | 942 | 3777 |
| PTPN6 | -98 | 2545 |
| RNASEL | 4023 | 3080 |
| SAMHD1 | 3588 | 7360 |
| SOCS1 | 1008 | 5666 |
| SOCS3 | -3912 | 698 |
| STAT1 | 4586 | 956 |
| STAT2 | 4613 | 3486 |
| TYK2 | -1202 | 1909 |
| USP18 | 4630 | -387 |
| XAF1 | 4649 | 4696 |
Mitochondrial translation elongation
| metric | value |
|---|---|
| setSize | 83 |
| pMANOVA | 2.4e-06 |
| p.adjustMANOVA | 6.43e-05 |
| s.dist | 0.318 |
| s.RNA | -0.299 |
| s.meth | -0.108 |
| p.RNA | 2.56e-06 |
| p.meth | 0.0902 |
| Gene | RNA | meth |
|---|---|---|
| MRPL23 | -4107 | -853 |
| MRPL27 | -2508 | -718 |
| MRPS2 | -4061 | -421 |
| MRPL45 | -2529 | -666 |
| MRPL9 | -3077 | -494 |
| MRPL20 | -1735 | -789 |
| GADD45GIP1 | -3882 | -350 |
| MRPL51 | -3529 | -289 |
| MRPL37 | -2893 | -302 |
| MRPL2 | -1326 | -436 |
| MRPL52 | -2450 | -146 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AURKAIP1 | -4305 | 3883 |
| CHCHD1 | -4141 | 3680 |
| DAP3 | -1774 | 143 |
| ERAL1 | -149 | 3775 |
| GADD45GIP1 | -3882 | -350 |
| GFM1 | -21 | 1365 |
| MRPL1 | 3546 | 218 |
| MRPL10 | 190 | 2279 |
| MRPL11 | -4247 | 4034 |
| MRPL12 | -4408 | 8276 |
| MRPL13 | 3162 | 7625 |
| MRPL14 | -3960 | 6345 |
| MRPL15 | -1773 | 5045 |
| MRPL16 | -523 | 7696 |
| MRPL18 | -756 | 3878 |
| MRPL19 | 2802 | 6054 |
| MRPL2 | -1326 | -436 |
| MRPL20 | -1735 | -789 |
| MRPL21 | -1930 | 1605 |
| MRPL22 | 340 | 6263 |
| MRPL23 | -4107 | -853 |
| MRPL24 | -4629 | 448 |
| MRPL27 | -2508 | -718 |
| MRPL30 | -330 | 5691 |
| MRPL32 | 1203 | 914 |
| MRPL33 | -1670 | 2858 |
| MRPL34 | -4554 | 789 |
| MRPL35 | 1364 | 463 |
| MRPL36 | -3032 | 8337 |
| MRPL37 | -2893 | -302 |
| MRPL38 | -3782 | 6626 |
| MRPL39 | 3247 | 4899 |
| MRPL4 | -39 | 7667 |
| MRPL41 | -2545 | 1540 |
| MRPL42 | 4573 | 3628 |
| MRPL43 | -4644 | 3498 |
| MRPL44 | 1858 | 2675 |
| MRPL45 | -2529 | -666 |
| MRPL46 | -1802 | 5122 |
| MRPL47 | 3068 | 6845 |
| MRPL48 | -1756 | 5652 |
| MRPL49 | -3523 | 6807 |
| MRPL50 | 1441 | 3835 |
| MRPL51 | -3529 | -289 |
| MRPL52 | -2450 | -146 |
| MRPL53 | -4115 | 971 |
| MRPL54 | -4663 | 1889 |
| MRPL55 | -3531 | 7479 |
| MRPL57 | -3056 | 4246 |
| MRPL9 | -3077 | -494 |
| MRPS10 | 3205 | -389 |
| MRPS11 | -872 | 1648 |
| MRPS12 | -4419 | 1712 |
| MRPS14 | 2200 | 1977 |
| MRPS15 | -3379 | 3677 |
| MRPS16 | -2474 | 2543 |
| MRPS17 | -205 | 3827 |
| MRPS18A | -781 | 7695 |
| MRPS18B | 272 | -766 |
| MRPS18C | 1393 | 6987 |
| MRPS2 | -4061 | -421 |
| MRPS21 | -4114 | 1464 |
| MRPS22 | 2497 | 6094 |
| MRPS23 | -2181 | 2254 |
| MRPS24 | -4381 | 3376 |
| MRPS25 | -473 | 6261 |
| MRPS26 | -4382 | 8045 |
| MRPS27 | 453 | 1421 |
| MRPS28 | -1744 | 3713 |
| MRPS30 | -726 | 5477 |
| MRPS31 | 2768 | 6499 |
| MRPS33 | -2318 | 3752 |
| MRPS34 | -4662 | 6347 |
| MRPS35 | 3530 | 3581 |
| MRPS36 | -59 | 2215 |
| MRPS5 | 1087 | 1128 |
| MRPS6 | -3427 | 3325 |
| MRPS7 | -4528 | 1415 |
| MRPS9 | -752 | 7560 |
| OXA1L | -1477 | 3023 |
| PTCD3 | 2243 | 1343 |
| TSFM | -2654 | 5010 |
| TUFM | -4324 | 1422 |
Cell Cycle Checkpoints
| metric | value |
|---|---|
| setSize | 221 |
| pMANOVA | 3.14e-05 |
| p.adjustMANOVA | 0.000821 |
| s.dist | 0.179 |
| s.RNA | 0.179 |
| s.meth | -0.0111 |
| p.RNA | 5.28e-06 |
| p.meth | 0.777 |
| Gene | RNA | meth |
|---|---|---|
| ORC3 | 3542 | -537 |
| RAD9B | 3824 | -278 |
| RNF168 | 1900 | -440 |
| PSMB2 | 1564 | -505 |
| TAOK1 | 2393 | -212 |
| MAPRE1 | 1882 | -252 |
| ANAPC10 | 1009 | -306 |
| UBE2S | 122 | -550 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AHCTF1 | 890 | 4249 |
| ANAPC1 | -2044 | 3351 |
| ANAPC10 | 1009 | -306 |
| ANAPC11 | -4292 | 7059 |
| ANAPC15 | -4084 | 2693 |
| ANAPC16 | -1049 | 6873 |
| ANAPC2 | -3136 | 1387 |
| ANAPC4 | 4429 | 1495 |
| ANAPC5 | 908 | 3142 |
| ANAPC7 | 3490 | 869 |
| ATM | 20 | 2443 |
| ATR | 3357 | 3477 |
| ATRIP | 1119 | 7937 |
| AURKB | -270 | 6999 |
| B9D2 | -2300 | 1375 |
| BABAM1 | -3555 | 8299 |
| BARD1 | 2320 | 7159 |
| BIRC5 | 2776 | 6260 |
| BLM | -425 | 3920 |
| BRCA1 | 3636 | 943 |
| BRIP1 | 3836 | 5492 |
| BUB1 | 3122 | 2187 |
| BUB1B | 968 | 1298 |
| BUB3 | 1488 | 3862 |
| CCNA2 | 1688 | 6920 |
| CCNB1 | 1497 | 903 |
| CCNB2 | 1174 | 2521 |
| CCNE1 | 3783 | 6755 |
| CCNE2 | 1042 | 5076 |
| CDC16 | 1994 | 7052 |
| CDC20 | -980 | 5845 |
| CDC23 | 1843 | 4397 |
| CDC25A | -1122 | 5081 |
| CDC6 | 661 | 155 |
| CDC7 | -400 | 1910 |
| CDCA8 | 1252 | 4578 |
| CDK1 | 3776 | 4292 |
| CDK2 | -1746 | 6577 |
| CDKN1A | 2610 | 7579 |
| CDKN1B | -1996 | 1658 |
| CDKN2A | 2101 | 4878 |
| CENPA | 178 | 4735 |
| CENPE | 4598 | 2619 |
| CENPF | 1922 | 3963 |
| CENPH | -84 | 4643 |
| CENPK | 3475 | 2021 |
| CENPL | 725 | 1951 |
| CENPM | 31 | 5307 |
| CENPN | 3528 | 816 |
| CENPO | -3933 | 1169 |
| CENPP | 1500 | 4875 |
| CENPQ | 3863 | 2988 |
| CENPT | -2466 | 6486 |
| CENPU | 3976 | 7227 |
| CHEK1 | 3054 | 3140 |
| CHEK2 | 1050 | 2255 |
| CKAP5 | 1716 | 2731 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CLIP1 | 4294 | 5562 |
| CLSPN | 3724 | 2818 |
| DBF4 | 3456 | 839 |
| DNA2 | 4145 | 1482 |
| DSN1 | 3674 | 2710 |
| DYNC1H1 | -363 | 1172 |
| DYNC1I2 | 1771 | 261 |
| DYNC1LI1 | 3057 | 6081 |
| DYNC1LI2 | 2777 | 3137 |
| DYNLL1 | -2331 | 5391 |
| DYNLL2 | -3503 | 3308 |
| EXO1 | 1471 | 4028 |
| GTSE1 | 3393 | 8287 |
| HUS1 | 3354 | 3330 |
| INCENP | -3143 | 744 |
| ITGB3BP | 225 | 6262 |
| KAT5 | -2212 | 5607 |
| KIF18A | 2120 | 2117 |
| KIF2A | -1929 | 107 |
| KIF2C | 3603 | 5613 |
| KNTC1 | 3117 | 7395 |
| MAD1L1 | 33 | 969 |
| MAD2L1 | 3079 | 1189 |
| MAPRE1 | 1882 | -252 |
| MCM10 | 1907 | 6878 |
| MCM2 | -2079 | 5046 |
| MCM3 | -2351 | 2065 |
| MCM4 | 1316 | 4341 |
| MCM5 | -2918 | 6723 |
| MCM6 | 684 | 7215 |
| MCM7 | -2385 | 2790 |
| MCM8 | 1624 | 4782 |
| MDC1 | -337 | 3873 |
| MDM2 | 4628 | 1092 |
| MDM4 | 3853 | 1115 |
| MIS12 | -416 | 8140 |
| NBN | 4170 | 1983 |
| NDC80 | 3673 | 2986 |
| NDE1 | 2131 | 2562 |
| NDEL1 | 126 | 6018 |
| NSL1 | 2939 | 5635 |
| NUDC | -3458 | 1037 |
| NUF2 | 2642 | 5100 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP160 | 1413 | 5801 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP85 | 1761 | 5415 |
| NUP98 | 111 | 1656 |
| ORC2 | 1400 | 7800 |
| ORC3 | 3542 | -537 |
| ORC4 | 3170 | 32 |
| ORC5 | 2335 | 5400 |
| ORC6 | 3424 | 2302 |
| PAFAH1B1 | -110 | 5606 |
| PCBP4 | -914 | 7919 |
| PHF20 | 274 | 2909 |
| PIAS4 | -2609 | 7610 |
| PKMYT1 | 534 | 6273 |
| PLK1 | 530 | 4665 |
| PMF1 | -953 | 2352 |
| PPP1CC | 4003 | 3213 |
| PPP2CA | 206 | 7715 |
| PPP2CB | 1868 | 15 |
| PPP2R1B | 2025 | 612 |
| PPP2R5A | 2564 | 1231 |
| PPP2R5B | 257 | 7072 |
| PPP2R5C | 1333 | 5914 |
| PPP2R5D | -1935 | 5740 |
| PPP2R5E | 2206 | 2424 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| RAD1 | 1778 | 2840 |
| RAD17 | 2171 | 2108 |
| RAD50 | 4602 | 179 |
| RAD9A | 947 | 6474 |
| RAD9B | 3824 | -278 |
| RANBP2 | 3159 | 4436 |
| RANGAP1 | -2765 | 6695 |
| RBBP8 | 4597 | 1067 |
| RCC2 | 728 | 3403 |
| RFC2 | -1865 | 6031 |
| RFC3 | 397 | 1603 |
| RFC4 | 600 | 4907 |
| RFC5 | 1499 | 7821 |
| RHNO1 | 118 | 8207 |
| RMI2 | 4428 | 4668 |
| RNF168 | 1900 | -440 |
| RNF8 | 2773 | 4447 |
| RPA1 | -3261 | 8080 |
| RPA3 | -460 | 1331 |
| RPS27A | -4637 | 2492 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SFN | -1182 | -556 |
| SKA2 | 3689 | 3206 |
| SPC24 | -272 | 5476 |
| SPDL1 | -2142 | -327 |
| SUMO1 | 2185 | 4431 |
| TAOK1 | 2393 | -212 |
| TOP3A | 2002 | 4401 |
| TOPBP1 | 3478 | 7075 |
| TP53 | -945 | 1992 |
| TP53BP1 | -432 | 2668 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2C | -2543 | 1584 |
| UBE2D1 | 2847 | 4705 |
| UBE2E1 | -429 | 3149 |
| UBE2N | 1732 | 6764 |
| UBE2S | 122 | -550 |
| UBE2V2 | 3712 | 5531 |
| UIMC1 | -341 | 7598 |
| WEE1 | 1915 | 480 |
| WRN | 1307 | 7146 |
| XPO1 | 4316 | 5628 |
| YWHAB | 3845 | 4090 |
| YWHAE | 2292 | 6202 |
| YWHAG | -1588 | 5676 |
| YWHAH | 1905 | 3469 |
| YWHAQ | -933 | 1317 |
| YWHAZ | 2673 | 2738 |
| ZW10 | 3610 | 4456 |
| ZWILCH | 4210 | 4734 |
| ZWINT | 1637 | 906 |
Mitochondrial translation termination
| metric | value |
|---|---|
| setSize | 82 |
| pMANOVA | 3.44e-05 |
| p.adjustMANOVA | 0.000878 |
| s.dist | 0.285 |
| s.RNA | -0.266 |
| s.meth | -0.102 |
| p.RNA | 3.23e-05 |
| p.meth | 0.11 |
| Gene | RNA | meth |
|---|---|---|
| MRPL23 | -4107 | -853 |
| MRPL27 | -2508 | -718 |
| MRPS2 | -4061 | -421 |
| MRPL45 | -2529 | -666 |
| MRPL9 | -3077 | -494 |
| MRPL20 | -1735 | -789 |
| GADD45GIP1 | -3882 | -350 |
| MRPL51 | -3529 | -289 |
| MRPL37 | -2893 | -302 |
| MRPL2 | -1326 | -436 |
| MRPL52 | -2450 | -146 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AURKAIP1 | -4305 | 3883 |
| CHCHD1 | -4141 | 3680 |
| DAP3 | -1774 | 143 |
| ERAL1 | -149 | 3775 |
| GADD45GIP1 | -3882 | -350 |
| GFM2 | 3218 | 4081 |
| MRPL1 | 3546 | 218 |
| MRPL10 | 190 | 2279 |
| MRPL11 | -4247 | 4034 |
| MRPL12 | -4408 | 8276 |
| MRPL13 | 3162 | 7625 |
| MRPL14 | -3960 | 6345 |
| MRPL15 | -1773 | 5045 |
| MRPL16 | -523 | 7696 |
| MRPL18 | -756 | 3878 |
| MRPL19 | 2802 | 6054 |
| MRPL2 | -1326 | -436 |
| MRPL20 | -1735 | -789 |
| MRPL21 | -1930 | 1605 |
| MRPL22 | 340 | 6263 |
| MRPL23 | -4107 | -853 |
| MRPL24 | -4629 | 448 |
| MRPL27 | -2508 | -718 |
| MRPL30 | -330 | 5691 |
| MRPL32 | 1203 | 914 |
| MRPL33 | -1670 | 2858 |
| MRPL34 | -4554 | 789 |
| MRPL35 | 1364 | 463 |
| MRPL36 | -3032 | 8337 |
| MRPL37 | -2893 | -302 |
| MRPL38 | -3782 | 6626 |
| MRPL39 | 3247 | 4899 |
| MRPL4 | -39 | 7667 |
| MRPL41 | -2545 | 1540 |
| MRPL42 | 4573 | 3628 |
| MRPL43 | -4644 | 3498 |
| MRPL44 | 1858 | 2675 |
| MRPL45 | -2529 | -666 |
| MRPL46 | -1802 | 5122 |
| MRPL47 | 3068 | 6845 |
| MRPL48 | -1756 | 5652 |
| MRPL49 | -3523 | 6807 |
| MRPL50 | 1441 | 3835 |
| MRPL51 | -3529 | -289 |
| MRPL52 | -2450 | -146 |
| MRPL53 | -4115 | 971 |
| MRPL54 | -4663 | 1889 |
| MRPL55 | -3531 | 7479 |
| MRPL57 | -3056 | 4246 |
| MRPL9 | -3077 | -494 |
| MRPS10 | 3205 | -389 |
| MRPS11 | -872 | 1648 |
| MRPS12 | -4419 | 1712 |
| MRPS14 | 2200 | 1977 |
| MRPS15 | -3379 | 3677 |
| MRPS16 | -2474 | 2543 |
| MRPS17 | -205 | 3827 |
| MRPS18A | -781 | 7695 |
| MRPS18B | 272 | -766 |
| MRPS18C | 1393 | 6987 |
| MRPS2 | -4061 | -421 |
| MRPS21 | -4114 | 1464 |
| MRPS22 | 2497 | 6094 |
| MRPS23 | -2181 | 2254 |
| MRPS24 | -4381 | 3376 |
| MRPS25 | -473 | 6261 |
| MRPS26 | -4382 | 8045 |
| MRPS27 | 453 | 1421 |
| MRPS28 | -1744 | 3713 |
| MRPS30 | -726 | 5477 |
| MRPS31 | 2768 | 6499 |
| MRPS33 | -2318 | 3752 |
| MRPS34 | -4662 | 6347 |
| MRPS35 | 3530 | 3581 |
| MRPS36 | -59 | 2215 |
| MRPS5 | 1087 | 1128 |
| MRPS6 | -3427 | 3325 |
| MRPS7 | -4528 | 1415 |
| MRPS9 | -752 | 7560 |
| MTRF1L | 3729 | 2552 |
| OXA1L | -1477 | 3023 |
| PTCD3 | 2243 | 1343 |
Mitotic Prometaphase
| metric | value |
|---|---|
| setSize | 155 |
| pMANOVA | 4.12e-05 |
| p.adjustMANOVA | 0.00103 |
| s.dist | 0.208 |
| s.RNA | 0.205 |
| s.meth | 0.0346 |
| p.RNA | 1.14e-05 |
| p.meth | 0.46 |
| Gene | RNA | meth |
|---|---|---|
| CEP290 | 4565 | 7343 |
| CENPU | 3976 | 7227 |
| CNTRL | 4569 | 6120 |
| HAUS2 | 3917 | 6842 |
| CEP63 | 3782 | 6456 |
| XPO1 | 4316 | 5628 |
| CLIP1 | 4294 | 5562 |
| FGFR1OP | 4057 | 5686 |
| KNTC1 | 3117 | 7395 |
| NCAPH | 3569 | 6187 |
| HAUS6 | 2889 | 7288 |
| KIF2C | 3603 | 5613 |
| ZWILCH | 4210 | 4734 |
| SMC3 | 3913 | 4966 |
| CEP164 | 3203 | 5860 |
| DYNC1LI1 | 3057 | 6081 |
| BIRC5 | 2776 | 6260 |
| SEH1L | 2536 | 6644 |
| HAUS8 | 2290 | 7348 |
| NSL1 | 2939 | 5635 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ACTR1A | -3110 | 886 |
| AHCTF1 | 890 | 4249 |
| AKAP9 | 4561 | 2144 |
| ALMS1 | 723 | 1376 |
| AURKB | -270 | 6999 |
| B9D2 | -2300 | 1375 |
| BIRC5 | 2776 | 6260 |
| BUB1 | 3122 | 2187 |
| BUB1B | 968 | 1298 |
| BUB3 | 1488 | 3862 |
| CCNB1 | 1497 | 903 |
| CCNB2 | 1174 | 2521 |
| CDC20 | -980 | 5845 |
| CDCA5 | 232 | 5231 |
| CDCA8 | 1252 | 4578 |
| CDK1 | 3776 | 4292 |
| CDK5RAP2 | 1553 | 2591 |
| CENPA | 178 | 4735 |
| CENPE | 4598 | 2619 |
| CENPF | 1922 | 3963 |
| CENPH | -84 | 4643 |
| CENPJ | 1344 | 1976 |
| CENPK | 3475 | 2021 |
| CENPL | 725 | 1951 |
| CENPM | 31 | 5307 |
| CENPN | 3528 | 816 |
| CENPO | -3933 | 1169 |
| CENPP | 1500 | 4875 |
| CENPQ | 3863 | 2988 |
| CENPT | -2466 | 6486 |
| CENPU | 3976 | 7227 |
| CEP131 | -3050 | 7043 |
| CEP135 | 4404 | 1908 |
| CEP152 | 4339 | 1496 |
| CEP164 | 3203 | 5860 |
| CEP192 | 3351 | 4425 |
| CEP250 | -1354 | 4877 |
| CEP290 | 4565 | 7343 |
| CEP41 | -1272 | 7536 |
| CEP63 | 3782 | 6456 |
| CEP70 | 938 | 6393 |
| CEP76 | 2440 | 3388 |
| CEP78 | -1195 | 7751 |
| CKAP5 | 1716 | 2731 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CLIP1 | 4294 | 5562 |
| CNTRL | 4569 | 6120 |
| CSNK1D | -3971 | 6586 |
| CSNK1E | -3456 | 7038 |
| CSNK2A2 | 1848 | 3957 |
| CSNK2B | -56 | 7503 |
| DCTN2 | -4181 | -467 |
| DCTN3 | -3566 | 4086 |
| DSN1 | 3674 | 2710 |
| DYNC1H1 | -363 | 1172 |
| DYNC1I2 | 1771 | 261 |
| DYNC1LI1 | 3057 | 6081 |
| DYNC1LI2 | 2777 | 3137 |
| DYNLL1 | -2331 | 5391 |
| DYNLL2 | -3503 | 3308 |
| EML4 | -549 | 28 |
| FGFR1OP | 4057 | 5686 |
| HAUS1 | 3006 | 4386 |
| HAUS2 | 3917 | 6842 |
| HAUS4 | -2057 | 5428 |
| HAUS5 | -259 | 4471 |
| HAUS6 | 2889 | 7288 |
| HAUS8 | 2290 | 7348 |
| HSP90AA1 | 2643 | 4876 |
| INCENP | -3143 | 744 |
| ITGB3BP | 225 | 6262 |
| KIF18A | 2120 | 2117 |
| KIF2A | -1929 | 107 |
| KIF2C | 3603 | 5613 |
| KNTC1 | 3117 | 7395 |
| MAD1L1 | 33 | 969 |
| MAD2L1 | 3079 | 1189 |
| MAPRE1 | 1882 | -252 |
| MIS12 | -416 | 8140 |
| MZT2A | -3898 | 8079 |
| NCAPD2 | -492 | 2885 |
| NCAPG | 3136 | 5112 |
| NCAPH | 3569 | 6187 |
| NDC80 | 3673 | 2986 |
| NDE1 | 2131 | 2562 |
| NDEL1 | 126 | 6018 |
| NEDD1 | 4146 | -233 |
| NEK2 | 3087 | 2451 |
| NEK6 | -3819 | 655 |
| NEK7 | 3335 | 686 |
| NEK9 | -2857 | 7406 |
| NME7 | 918 | 8289 |
| NSL1 | 2939 | 5635 |
| NUDC | -3458 | 1037 |
| NUF2 | 2642 | 5100 |
| NUMA1 | -3466 | 3306 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP160 | 1413 | 5801 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP85 | 1761 | 5415 |
| NUP98 | 111 | 1656 |
| ODF2 | -2372 | 5123 |
| PAFAH1B1 | -110 | 5606 |
| PCM1 | 3024 | 2291 |
| PCNT | -2972 | 2386 |
| PDS5A | 2442 | 4720 |
| PDS5B | 2163 | 614 |
| PLK1 | 530 | 4665 |
| PLK4 | 2628 | 2938 |
| PMF1 | -953 | 2352 |
| PPP1CC | 4003 | 3213 |
| PPP2CA | 206 | 7715 |
| PPP2CB | 1868 | 15 |
| PPP2R1B | 2025 | 612 |
| PPP2R5A | 2564 | 1231 |
| PPP2R5B | 257 | 7072 |
| PPP2R5C | 1333 | 5914 |
| PPP2R5D | -1935 | 5740 |
| PPP2R5E | 2206 | 2424 |
| PRKACA | -456 | 3985 |
| RAD21 | 920 | 2688 |
| RANBP2 | 3159 | 4436 |
| RANGAP1 | -2765 | 6695 |
| RCC2 | 728 | 3403 |
| SDCCAG8 | 1336 | 1961 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SKA2 | 3689 | 3206 |
| SMC2 | 4304 | 1398 |
| SMC3 | 3913 | 4966 |
| SMC4 | 4551 | 3185 |
| SPC24 | -272 | 5476 |
| SPDL1 | -2142 | -327 |
| SSNA1 | -4591 | 6709 |
| STAG1 | -1499 | 2912 |
| TAOK1 | 2393 | -212 |
| TUBA1A | -757 | 1542 |
| TUBA4A | -2882 | 7151 |
| TUBB | -1422 | 3715 |
| TUBB4B | -1484 | 6419 |
| TUBG1 | 701 | 8221 |
| TUBG2 | -1390 | 3395 |
| TUBGCP2 | -2921 | 7827 |
| TUBGCP3 | 1623 | 8013 |
| TUBGCP5 | 4542 | -597 |
| TUBGCP6 | -2196 | 3584 |
| XPO1 | 4316 | 5628 |
| YWHAE | 2292 | 6202 |
| YWHAG | -1588 | 5676 |
| ZW10 | 3610 | 4456 |
| ZWILCH | 4210 | 4734 |
| ZWINT | 1637 | 906 |
Mitochondrial translation initiation
| metric | value |
|---|---|
| setSize | 83 |
| pMANOVA | 4.56e-05 |
| p.adjustMANOVA | 0.00111 |
| s.dist | 0.28 |
| s.RNA | -0.261 |
| s.meth | -0.0988 |
| p.RNA | 3.98e-05 |
| p.meth | 0.121 |
| Gene | RNA | meth |
|---|---|---|
| MRPL23 | -4107 | -853 |
| MRPL27 | -2508 | -718 |
| MRPS2 | -4061 | -421 |
| MRPL45 | -2529 | -666 |
| MRPL9 | -3077 | -494 |
| MRPL20 | -1735 | -789 |
| GADD45GIP1 | -3882 | -350 |
| MRPL51 | -3529 | -289 |
| MRPL37 | -2893 | -302 |
| MRPL2 | -1326 | -436 |
| MRPL52 | -2450 | -146 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AURKAIP1 | -4305 | 3883 |
| CHCHD1 | -4141 | 3680 |
| DAP3 | -1774 | 143 |
| ERAL1 | -149 | 3775 |
| GADD45GIP1 | -3882 | -350 |
| MRPL1 | 3546 | 218 |
| MRPL10 | 190 | 2279 |
| MRPL11 | -4247 | 4034 |
| MRPL12 | -4408 | 8276 |
| MRPL13 | 3162 | 7625 |
| MRPL14 | -3960 | 6345 |
| MRPL15 | -1773 | 5045 |
| MRPL16 | -523 | 7696 |
| MRPL18 | -756 | 3878 |
| MRPL19 | 2802 | 6054 |
| MRPL2 | -1326 | -436 |
| MRPL20 | -1735 | -789 |
| MRPL21 | -1930 | 1605 |
| MRPL22 | 340 | 6263 |
| MRPL23 | -4107 | -853 |
| MRPL24 | -4629 | 448 |
| MRPL27 | -2508 | -718 |
| MRPL30 | -330 | 5691 |
| MRPL32 | 1203 | 914 |
| MRPL33 | -1670 | 2858 |
| MRPL34 | -4554 | 789 |
| MRPL35 | 1364 | 463 |
| MRPL36 | -3032 | 8337 |
| MRPL37 | -2893 | -302 |
| MRPL38 | -3782 | 6626 |
| MRPL39 | 3247 | 4899 |
| MRPL4 | -39 | 7667 |
| MRPL41 | -2545 | 1540 |
| MRPL42 | 4573 | 3628 |
| MRPL43 | -4644 | 3498 |
| MRPL44 | 1858 | 2675 |
| MRPL45 | -2529 | -666 |
| MRPL46 | -1802 | 5122 |
| MRPL47 | 3068 | 6845 |
| MRPL48 | -1756 | 5652 |
| MRPL49 | -3523 | 6807 |
| MRPL50 | 1441 | 3835 |
| MRPL51 | -3529 | -289 |
| MRPL52 | -2450 | -146 |
| MRPL53 | -4115 | 971 |
| MRPL54 | -4663 | 1889 |
| MRPL55 | -3531 | 7479 |
| MRPL57 | -3056 | 4246 |
| MRPL9 | -3077 | -494 |
| MRPS10 | 3205 | -389 |
| MRPS11 | -872 | 1648 |
| MRPS12 | -4419 | 1712 |
| MRPS14 | 2200 | 1977 |
| MRPS15 | -3379 | 3677 |
| MRPS16 | -2474 | 2543 |
| MRPS17 | -205 | 3827 |
| MRPS18A | -781 | 7695 |
| MRPS18B | 272 | -766 |
| MRPS18C | 1393 | 6987 |
| MRPS2 | -4061 | -421 |
| MRPS21 | -4114 | 1464 |
| MRPS22 | 2497 | 6094 |
| MRPS23 | -2181 | 2254 |
| MRPS24 | -4381 | 3376 |
| MRPS25 | -473 | 6261 |
| MRPS26 | -4382 | 8045 |
| MRPS27 | 453 | 1421 |
| MRPS28 | -1744 | 3713 |
| MRPS30 | -726 | 5477 |
| MRPS31 | 2768 | 6499 |
| MRPS33 | -2318 | 3752 |
| MRPS34 | -4662 | 6347 |
| MRPS35 | 3530 | 3581 |
| MRPS36 | -59 | 2215 |
| MRPS5 | 1087 | 1128 |
| MRPS6 | -3427 | 3325 |
| MRPS7 | -4528 | 1415 |
| MRPS9 | -752 | 7560 |
| MTFMT | -90 | 3569 |
| MTIF2 | 3537 | 5667 |
| MTIF3 | 4044 | 2054 |
| OXA1L | -1477 | 3023 |
| PTCD3 | 2243 | 1343 |
Mitochondrial translation
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 5.78e-05 |
| p.adjustMANOVA | 0.00138 |
| s.dist | 0.268 |
| s.RNA | -0.247 |
| s.meth | -0.104 |
| p.RNA | 6.57e-05 |
| p.meth | 0.0916 |
| Gene | RNA | meth |
|---|---|---|
| MRPL23 | -4107 | -853 |
| MRPL27 | -2508 | -718 |
| MRPS2 | -4061 | -421 |
| MRPL45 | -2529 | -666 |
| MRPL9 | -3077 | -494 |
| MRPL20 | -1735 | -789 |
| GADD45GIP1 | -3882 | -350 |
| MRPL51 | -3529 | -289 |
| MRPL37 | -2893 | -302 |
| MRPL2 | -1326 | -436 |
| MRPL52 | -2450 | -146 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AURKAIP1 | -4305 | 3883 |
| CHCHD1 | -4141 | 3680 |
| DAP3 | -1774 | 143 |
| ERAL1 | -149 | 3775 |
| GADD45GIP1 | -3882 | -350 |
| GFM1 | -21 | 1365 |
| GFM2 | 3218 | 4081 |
| MRPL1 | 3546 | 218 |
| MRPL10 | 190 | 2279 |
| MRPL11 | -4247 | 4034 |
| MRPL12 | -4408 | 8276 |
| MRPL13 | 3162 | 7625 |
| MRPL14 | -3960 | 6345 |
| MRPL15 | -1773 | 5045 |
| MRPL16 | -523 | 7696 |
| MRPL18 | -756 | 3878 |
| MRPL19 | 2802 | 6054 |
| MRPL2 | -1326 | -436 |
| MRPL20 | -1735 | -789 |
| MRPL21 | -1930 | 1605 |
| MRPL22 | 340 | 6263 |
| MRPL23 | -4107 | -853 |
| MRPL24 | -4629 | 448 |
| MRPL27 | -2508 | -718 |
| MRPL30 | -330 | 5691 |
| MRPL32 | 1203 | 914 |
| MRPL33 | -1670 | 2858 |
| MRPL34 | -4554 | 789 |
| MRPL35 | 1364 | 463 |
| MRPL36 | -3032 | 8337 |
| MRPL37 | -2893 | -302 |
| MRPL38 | -3782 | 6626 |
| MRPL39 | 3247 | 4899 |
| MRPL4 | -39 | 7667 |
| MRPL41 | -2545 | 1540 |
| MRPL42 | 4573 | 3628 |
| MRPL43 | -4644 | 3498 |
| MRPL44 | 1858 | 2675 |
| MRPL45 | -2529 | -666 |
| MRPL46 | -1802 | 5122 |
| MRPL47 | 3068 | 6845 |
| MRPL48 | -1756 | 5652 |
| MRPL49 | -3523 | 6807 |
| MRPL50 | 1441 | 3835 |
| MRPL51 | -3529 | -289 |
| MRPL52 | -2450 | -146 |
| MRPL53 | -4115 | 971 |
| MRPL54 | -4663 | 1889 |
| MRPL55 | -3531 | 7479 |
| MRPL57 | -3056 | 4246 |
| MRPL9 | -3077 | -494 |
| MRPS10 | 3205 | -389 |
| MRPS11 | -872 | 1648 |
| MRPS12 | -4419 | 1712 |
| MRPS14 | 2200 | 1977 |
| MRPS15 | -3379 | 3677 |
| MRPS16 | -2474 | 2543 |
| MRPS17 | -205 | 3827 |
| MRPS18A | -781 | 7695 |
| MRPS18B | 272 | -766 |
| MRPS18C | 1393 | 6987 |
| MRPS2 | -4061 | -421 |
| MRPS21 | -4114 | 1464 |
| MRPS22 | 2497 | 6094 |
| MRPS23 | -2181 | 2254 |
| MRPS24 | -4381 | 3376 |
| MRPS25 | -473 | 6261 |
| MRPS26 | -4382 | 8045 |
| MRPS27 | 453 | 1421 |
| MRPS28 | -1744 | 3713 |
| MRPS30 | -726 | 5477 |
| MRPS31 | 2768 | 6499 |
| MRPS33 | -2318 | 3752 |
| MRPS34 | -4662 | 6347 |
| MRPS35 | 3530 | 3581 |
| MRPS36 | -59 | 2215 |
| MRPS5 | 1087 | 1128 |
| MRPS6 | -3427 | 3325 |
| MRPS7 | -4528 | 1415 |
| MRPS9 | -752 | 7560 |
| MTFMT | -90 | 3569 |
| MTIF2 | 3537 | 5667 |
| MTIF3 | 4044 | 2054 |
| MTRF1L | 3729 | 2552 |
| OXA1L | -1477 | 3023 |
| PTCD3 | 2243 | 1343 |
| TSFM | -2654 | 5010 |
| TUFM | -4324 | 1422 |
Antiviral mechanism by IFN-stimulated genes
| metric | value |
|---|---|
| setSize | 77 |
| pMANOVA | 6.32e-05 |
| p.adjustMANOVA | 0.00148 |
| s.dist | 0.294 |
| s.RNA | 0.281 |
| s.meth | -0.0867 |
| p.RNA | 2.06e-05 |
| p.meth | 0.189 |
| Gene | RNA | meth |
|---|---|---|
| ISG15 | 4539 | -542 |
| EIF4E3 | 3243 | -728 |
| USP18 | 4630 | -387 |
| MX2 | 4636 | -241 |
| OAS1 | 4608 | -193 |
| PDE12 | 1736 | -503 |
| PPM1B | 3762 | -194 |
| NDC1 | 131 | -274 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ABCE1 | 2436 | 2902 |
| ARIH1 | 2692 | 5841 |
| DDX58 | 4611 | 2919 |
| EIF2AK2 | 4648 | 189 |
| EIF4A1 | -335 | 5352 |
| EIF4A2 | 1338 | 5327 |
| EIF4A3 | -3302 | 5329 |
| EIF4E | 3529 | 5614 |
| EIF4E2 | -1364 | 2810 |
| EIF4E3 | 3243 | -728 |
| EIF4G1 | -2084 | 3220 |
| EIF4G2 | 1209 | 6231 |
| EIF4G3 | 2013 | 900 |
| FLNB | -950 | 3896 |
| HERC5 | 4645 | 1229 |
| IFIT1 | 4635 | 25 |
| IRF3 | -2843 | 2803 |
| ISG15 | 4539 | -542 |
| JAK1 | -3728 | 6986 |
| KPNA1 | 2627 | 6172 |
| KPNA2 | 3157 | 843 |
| KPNA3 | 3283 | 1404 |
| KPNA4 | 3489 | 8152 |
| KPNA5 | 4177 | 1689 |
| KPNB1 | 3511 | 5921 |
| MAPK3 | -4654 | -479 |
| MX1 | 4607 | 1151 |
| MX2 | 4636 | -241 |
| NDC1 | 131 | -274 |
| NEDD4 | 3533 | 6220 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| OAS1 | 4608 | -193 |
| OAS2 | 4638 | 3133 |
| OAS3 | 4612 | 5423 |
| OASL | 4547 | 6420 |
| PDE12 | 1736 | -503 |
| PIN1 | -4555 | 3781 |
| PLCG1 | -1509 | 5809 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PPM1B | 3762 | -194 |
| RAE1 | -413 | 710 |
| RANBP2 | 3159 | 4436 |
| RNASEL | 4023 | 3080 |
| RPS27A | -4637 | 2492 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| STAT1 | 4586 | 956 |
| TPR | 3600 | 5135 |
| TRIM25 | 4122 | 6656 |
| UBA52 | -4418 | 4404 |
| UBA7 | 1257 | 3041 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2E1 | -429 | 3149 |
| UBE2L6 | 4230 | 765 |
| UBE2N | 1732 | 6764 |
| USP18 | 4630 | -387 |
Complex I biogenesis
| metric | value |
|---|---|
| setSize | 41 |
| pMANOVA | 7.41e-05 |
| p.adjustMANOVA | 0.00167 |
| s.dist | 0.389 |
| s.RNA | -0.379 |
| s.meth | -0.0874 |
| p.RNA | 2.69e-05 |
| p.meth | 0.334 |
| Gene | RNA | meth |
|---|---|---|
| NDUFAF4 | -2177 | -161 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| ECSIT | -3251 | 6323 |
| NDUFA10 | -986 | 5793 |
| NDUFA11 | -2911 | 601 |
| NDUFA12 | -1521 | 729 |
| NDUFA13 | -4530 | 5091 |
| NDUFA2 | -4592 | 3313 |
| NDUFA3 | -3134 | 7304 |
| NDUFA5 | 3682 | 333 |
| NDUFA6 | -3137 | 4184 |
| NDUFA7 | -3111 | 2639 |
| NDUFA8 | 205 | 5072 |
| NDUFA9 | 3596 | 7361 |
| NDUFAB1 | -2963 | 1043 |
| NDUFAF1 | 1061 | 426 |
| NDUFAF2 | -606 | 2075 |
| NDUFAF3 | -3750 | 1824 |
| NDUFAF4 | -2177 | -161 |
| NDUFAF5 | 199 | -133 |
| NDUFAF6 | 2079 | -482 |
| NDUFB1 | -4027 | 7880 |
| NDUFB10 | -4425 | 4926 |
| NDUFB2 | -4321 | 8398 |
| NDUFB3 | -2008 | 5110 |
| NDUFB4 | -3151 | 1638 |
| NDUFB5 | 2559 | 3909 |
| NDUFB7 | -3940 | 4869 |
| NDUFB9 | -4113 | 4749 |
| NDUFC1 | -2413 | 2107 |
| NDUFC2 | -4064 | 5333 |
| NDUFS1 | 1302 | -31 |
| NDUFS2 | -2363 | 57 |
| NDUFS3 | -3256 | 193 |
| NDUFS4 | 1065 | 6272 |
| NDUFS5 | -3236 | 5637 |
| NDUFS6 | -4288 | 6204 |
| NDUFS7 | -3402 | 5729 |
| NDUFS8 | -3980 | 102 |
| NDUFV1 | -3895 | 4359 |
| NDUFV2 | 1839 | 1025 |
| NDUFV3 | 1256 | 6531 |
| TMEM126B | 2113 | 440 |
Cell Cycle
| metric | value |
|---|---|
| setSize | 515 |
| pMANOVA | 7.41e-05 |
| p.adjustMANOVA | 0.00167 |
| s.dist | 0.115 |
| s.RNA | 0.113 |
| s.meth | -0.0187 |
| p.RNA | 1.47e-05 |
| p.meth | 0.476 |
| Gene | RNA | meth |
|---|---|---|
| MIS18BP1 | 4505 | -813 |
| TUBGCP5 | 4542 | -597 |
| SMC1B | 4199 | -549 |
| ORC3 | 3542 | -537 |
| RAD9B | 3824 | -278 |
| NEDD1 | 4146 | -233 |
| RNF168 | 1900 | -440 |
| PPP1CB | 3653 | -226 |
| PSMB2 | 1564 | -505 |
| CCND2 | 1000 | -618 |
| GINS4 | 1765 | -298 |
| TAOK1 | 2393 | -212 |
| GORASP1 | 1109 | -452 |
| MAPRE1 | 1882 | -252 |
| ANAPC10 | 1009 | -306 |
| LMNA | 580 | -409 |
| TK1 | 338 | -581 |
| KIF20A | 1006 | -149 |
| CHMP3 | 1593 | -59 |
| SRC | 831 | -92 |
Click HERE to show all gene set members
| RNA | meth | |
|---|---|---|
| AAAS | -2025 | 2730 |
| ABL1 | -2415 | 5977 |
| ACD | -4048 | 3685 |
| ACTR1A | -3110 | 886 |
| AHCTF1 | 890 | 4249 |
| AJUBA | -567 | -835 |
| AKAP9 | 4561 | 2144 |
| AKT1 | -4019 | 4230 |
| AKT2 | -4353 | 3475 |
| ALMS1 | 723 | 1376 |
| ANAPC1 | -2044 | 3351 |
| ANAPC10 | 1009 | -306 |
| ANAPC11 | -4292 | 7059 |
| ANAPC15 | -4084 | 2693 |
| ANAPC16 | -1049 | 6873 |
| ANAPC2 | -3136 | 1387 |
| ANAPC4 | 4429 | 1495 |
| ANAPC5 | 908 | 3142 |
| ANAPC7 | 3490 | 869 |
| ANKLE2 | -536 | 1688 |
| ANKRD28 | -1152 | 7506 |
| ARPP19 | 1809 | 3109 |
| ATM | 20 | 2443 |
| ATR | 3357 | 3477 |
| ATRIP | 1119 | 7937 |
| AURKA | 3334 | 3139 |
| AURKB | -270 | 6999 |
| B9D2 | -2300 | 1375 |
| BABAM1 | -3555 | 8299 |
| BANF1 | -4277 | 4199 |
| BARD1 | 2320 | 7159 |
| BIRC5 | 2776 | 6260 |
| BLM | -425 | 3920 |
| BLZF1 | 4566 | 3144 |
| BORA | 3981 | 434 |
| BRCA1 | 3636 | 943 |
| BRCA2 | 4552 | 151 |
| BRIP1 | 3836 | 5492 |
| BTRC | -3793 | 66 |
| BUB1 | 3122 | 2187 |
| BUB1B | 968 | 1298 |
| BUB3 | 1488 | 3862 |
| CC2D1B | -3881 | 1119 |
| CCNA2 | 1688 | 6920 |
| CCNB1 | 1497 | 903 |
| CCNB2 | 1174 | 2521 |
| CCND1 | 2030 | 3568 |
| CCND2 | 1000 | -618 |
| CCND3 | -1137 | 2914 |
| CCNE1 | 3783 | 6755 |
| CCNE2 | 1042 | 5076 |
| CCNH | 4336 | 5990 |
| CDC14A | -1193 | 7702 |
| CDC16 | 1994 | 7052 |
| CDC20 | -980 | 5845 |
| CDC23 | 1843 | 4397 |
| CDC25A | -1122 | 5081 |
| CDC25B | -118 | 1268 |
| CDC6 | 661 | 155 |
| CDC7 | -400 | 1910 |
| CDCA5 | 232 | 5231 |
| CDCA8 | 1252 | 4578 |
| CDK1 | 3776 | 4292 |
| CDK11A | 52 | -211 |
| CDK11B | -2406 | 3378 |
| CDK2 | -1746 | 6577 |
| CDK4 | -4272 | 6700 |
| CDK5RAP2 | 1553 | 2591 |
| CDK6 | 3142 | 2094 |
| CDK7 | 3468 | 3672 |
| CDKN1A | 2610 | 7579 |
| CDKN1B | -1996 | 1658 |
| CDKN2A | 2101 | 4878 |
| CDKN2C | -3393 | 4213 |
| CDKN2D | -4602 | 5171 |
| CDT1 | -1852 | 2816 |
| CENPA | 178 | 4735 |
| CENPE | 4598 | 2619 |
| CENPF | 1922 | 3963 |
| CENPH | -84 | 4643 |
| CENPJ | 1344 | 1976 |
| CENPK | 3475 | 2021 |
| CENPL | 725 | 1951 |
| CENPM | 31 | 5307 |
| CENPN | 3528 | 816 |
| CENPO | -3933 | 1169 |
| CENPP | 1500 | 4875 |
| CENPQ | 3863 | 2988 |
| CENPT | -2466 | 6486 |
| CENPU | 3976 | 7227 |
| CEP131 | -3050 | 7043 |
| CEP135 | 4404 | 1908 |
| CEP152 | 4339 | 1496 |
| CEP164 | 3203 | 5860 |
| CEP192 | 3351 | 4425 |
| CEP250 | -1354 | 4877 |
| CEP290 | 4565 | 7343 |
| CEP41 | -1272 | 7536 |
| CEP63 | 3782 | 6456 |
| CEP70 | 938 | 6393 |
| CEP76 | 2440 | 3388 |
| CEP78 | -1195 | 7751 |
| CHEK1 | 3054 | 3140 |
| CHEK2 | 1050 | 2255 |
| CHMP2A | -2940 | 7013 |
| CHMP2B | 3798 | 5744 |
| CHMP3 | 1593 | -59 |
| CHMP4A | 1274 | 1773 |
| CHMP4B | -2895 | 4124 |
| CHMP6 | -4489 | 1561 |
| CHMP7 | -2381 | 6937 |
| CHTF18 | -4351 | 1046 |
| CHTF8 | -3269 | 4031 |
| CKAP5 | 1716 | 2731 |
| CKS1B | 3075 | 751 |
| CLASP1 | -2012 | 3286 |
| CLASP2 | 2483 | 2891 |
| CLIP1 | 4294 | 5562 |
| CLSPN | 3724 | 2818 |
| CNEP1R1 | 4277 | 4761 |
| CNTRL | 4569 | 6120 |
| CSNK1D | -3971 | 6586 |
| CSNK1E | -3456 | 7038 |
| CSNK2A2 | 1848 | 3957 |
| CSNK2B | -56 | 7503 |
| CTC1 | -2223 | 5242 |
| CTDNEP1 | -4358 | -247 |
| CUL1 | 4584 | 1579 |
| DAXX | -1619 | 3531 |
| DBF4 | 3456 | 839 |
| DCTN2 | -4181 | -467 |
| DCTN3 | -3566 | 4086 |
| DHFR | 1251 | 224 |
| DIDO1 | -3004 | 1952 |
| DNA2 | 4145 | 1482 |
| DSCC1 | 477 | 2405 |
| DSN1 | 3674 | 2710 |
| DYNC1H1 | -363 | 1172 |
| DYNC1I2 | 1771 | 261 |
| DYNC1LI1 | 3057 | 6081 |
| DYNC1LI2 | 2777 | 3137 |
| DYNLL1 | -2331 | 5391 |
| DYNLL2 | -3503 | 3308 |
| DYRK1A | -1564 | 7765 |
| E2F1 | 2277 | 1130 |
| E2F2 | 1158 | 3021 |
| E2F3 | 3158 | 5634 |
| E2F4 | -3659 | 838 |
| E2F5 | -487 | 2528 |
| E2F6 | -232 | 5818 |
| EML4 | -549 | 28 |
| ENSA | -4043 | 901 |
| EP300 | 1140 | 3364 |
| ESCO1 | 3995 | 4740 |
| ESCO2 | 3246 | 1981 |
| ESPL1 | 3300 | 4938 |
| EXO1 | 1471 | 4028 |
| FBXL18 | -187 | 5498 |
| FBXO5 | 3464 | 2393 |
| FBXW11 | -2041 | 8437 |
| FEN1 | -2465 | 5510 |
| FGFR1OP | 4057 | 5686 |
| FKBPL | -520 | 4889 |
| FOXM1 | 3368 | 128 |
| FZR1 | -2370 | 7430 |
| GAR1 | -1241 | 3773 |
| GINS1 | 3100 | 2261 |
| GINS3 | 647 | 7805 |
| GINS4 | 1765 | -298 |
| GMNN | 1986 | 4368 |
| GOLGA2 | 281 | 1717 |
| GORASP1 | 1109 | -452 |
| GORASP2 | -1025 | 684 |
| GSK3B | -53 | 3637 |
| GTSE1 | 3393 | 8287 |
| HAUS1 | 3006 | 4386 |
| HAUS2 | 3917 | 6842 |
| HAUS4 | -2057 | 5428 |
| HAUS5 | -259 | 4471 |
| HAUS6 | 2889 | 7288 |
| HAUS8 | 2290 | 7348 |
| HDAC1 | -3348 | 4910 |
| HJURP | 1617 | 6161 |
| HMMR | 1492 | 3599 |
| HSP90AA1 | 2643 | 4876 |
| HSP90AB1 | -1590 | 829 |
| HSPA2 | -2606 | 5784 |
| HUS1 | 3354 | 3330 |
| INCENP | -3143 | 744 |
| IST1 | 44 | 1933 |
| ITGB3BP | 225 | 6262 |
| JAK2 | 4633 | 6248 |
| KAT5 | -2212 | 5607 |
| KIF18A | 2120 | 2117 |
| KIF20A | 1006 | -149 |
| KIF23 | 2125 | 2575 |
| KIF2A | -1929 | 107 |
| KIF2C | 3603 | 5613 |
| KNTC1 | 3117 | 7395 |
| KPNB1 | 3511 | 5921 |
| LBR | 657 | 84 |
| LCMT1 | -2344 | 3223 |
| LEMD2 | -3931 | 5142 |
| LEMD3 | -1600 | 5873 |
| LIG1 | -2821 | 1862 |
| LIN37 | -1109 | 5733 |
| LIN52 | 3008 | 6009 |
| LIN54 | 1984 | 3183 |
| LIN9 | 1859 | 6299 |
| LMNA | 580 | -409 |
| LMNB1 | 4058 | 4104 |
| LPIN1 | 1325 | 5878 |
| LPIN2 | 2176 | 5561 |
| MAD1L1 | 33 | 969 |
| MAD2L1 | 3079 | 1189 |
| MAPK1 | 300 | 2770 |
| MAPK3 | -4654 | -479 |
| MAPRE1 | 1882 | -252 |
| MAX | -921 | 5533 |
| MCM10 | 1907 | 6878 |
| MCM2 | -2079 | 5046 |
| MCM3 | -2351 | 2065 |
| MCM4 | 1316 | 4341 |
| MCM5 | -2918 | 6723 |
| MCM6 | 684 | 7215 |
| MCM7 | -2385 | 2790 |
| MCM8 | 1624 | 4782 |
| MCPH1 | 966 | 3225 |
| MDC1 | -337 | 3873 |
| MDM2 | 4628 | 1092 |
| MDM4 | 3853 | 1115 |
| MIS12 | -416 | 8140 |
| MIS18A | -1731 | -34 |
| MIS18BP1 | 4505 | -813 |
| MLH3 | -2817 | 3420 |
| MNAT1 | 56 | 2609 |
| MSH5 | 2821 | 3190 |
| MZT2A | -3898 | 8079 |
| NBN | 4170 | 1983 |
| NCAPD2 | -492 | 2885 |
| NCAPD3 | -1571 | 1252 |
| NCAPG | 3136 | 5112 |
| NCAPG2 | -1020 | 6565 |
| NCAPH | 3569 | 6187 |
| NCAPH2 | -3522 | 1725 |
| NDC1 | 131 | -274 |
| NDC80 | 3673 | 2986 |
| NDE1 | 2131 | 2562 |
| NDEL1 | 126 | 6018 |
| NEDD1 | 4146 | -233 |
| NEK2 | 3087 | 2451 |
| NEK6 | -3819 | 655 |
| NEK7 | 3335 | 686 |
| NEK9 | -2857 | 7406 |
| NHP2 | -4201 | 6994 |
| NIPBL | 2971 | 4332 |
| NME7 | 918 | 8289 |
| NOP10 | -3662 | 2404 |
| NSL1 | 2939 | 5635 |
| NUDC | -3458 | 1037 |
| NUF2 | 2642 | 5100 |
| NUMA1 | -3466 | 3306 |
| NUP107 | 3609 | 1024 |
| NUP133 | 618 | 1480 |
| NUP153 | 292 | 7289 |
| NUP155 | 1972 | 5103 |
| NUP160 | 1413 | 5801 |
| NUP188 | -2259 | 596 |
| NUP205 | -88 | 373 |
| NUP210 | -2729 | 780 |
| NUP214 | 882 | 7349 |
| NUP35 | -1253 | 7594 |
| NUP37 | -620 | 503 |
| NUP43 | 3769 | 140 |
| NUP50 | 3580 | 5792 |
| NUP54 | 4362 | 6539 |
| NUP62 | -1558 | 2715 |
| NUP85 | 1761 | 5415 |
| NUP88 | -811 | 6451 |
| NUP93 | 3550 | 7878 |
| NUP98 | 111 | 1656 |
| ODF2 | -2372 | 5123 |
| OIP5 | 2345 | 5646 |
| OPTN | 804 | 3563 |
| ORC2 | 1400 | 7800 |
| ORC3 | 3542 | -537 |
| ORC4 | 3170 | 32 |
| ORC5 | 2335 | 5400 |
| ORC6 | 3424 | 2302 |
| PAFAH1B1 | -110 | 5606 |
| PCBP4 | -914 | 7919 |
| PCM1 | 3024 | 2291 |
| PCNA | 881 | 4219 |
| PCNT | -2972 | 2386 |
| PDS5A | 2442 | 4720 |
| PDS5B | 2163 | 614 |
| PHF20 | 274 | 2909 |
| PHLDA1 | 2860 | 5055 |
| PIAS4 | -2609 | 7610 |
| PIF1 | -550 | 51 |
| PKMYT1 | 534 | 6273 |
| PLK1 | 530 | 4665 |
| PLK4 | 2628 | 2938 |
| PMF1 | -953 | 2352 |
| POLA2 | 3140 | 5083 |
| POLD1 | -4148 | 753 |
| POLD2 | -4233 | 408 |
| POLD3 | 3703 | 1553 |
| POLD4 | -3735 | 4449 |
| POLE | 991 | 5293 |
| POLE2 | 4024 | 7989 |
| POLE3 | -4042 | 1562 |
| POLE4 | -3192 | 6198 |
| POLR2A | 69 | -175 |
| POLR2B | 704 | 1497 |
| POLR2C | -3573 | 4506 |
| POLR2D | 1768 | 1352 |
| POLR2E | -4269 | 2995 |
| POLR2F | -4459 | 6542 |
| POLR2G | -4291 | 8051 |
| POLR2H | -4045 | 7582 |
| POLR2I | -4354 | 6360 |
| POLR2K | 2165 | 2463 |
| POM121 | -2201 | 5167 |
| POM121C | -2827 | 5663 |
| PPME1 | 2415 | 977 |
| PPP1CB | 3653 | -226 |
| PPP1CC | 4003 | 3213 |
| PPP1R12A | 3768 | 2879 |
| PPP1R12B | 446 | 3491 |
| PPP2CA | 206 | 7715 |
| PPP2CB | 1868 | 15 |
| PPP2R1B | 2025 | 612 |
| PPP2R2A | 4512 | 545 |
| PPP2R5A | 2564 | 1231 |
| PPP2R5B | 257 | 7072 |
| PPP2R5C | 1333 | 5914 |
| PPP2R5D | -1935 | 5740 |
| PPP2R5E | 2206 | 2424 |
| PPP6C | 3027 | 45 |
| PPP6R3 | 3328 | 5905 |
| PRIM1 | 2596 | 5416 |
| PRIM2 | 18 | 276 |
| PRKACA | -456 | 3985 |
| PRKCA | -1818 | 8000 |
| PRKCB | -359 | 4210 |
| PSMA1 | 1297 | 5226 |
| PSMA2 | -871 | 4948 |
| PSMA3 | 4546 | 1439 |
| PSMA5 | 1130 | 4192 |
| PSMA6 | 3966 | 6164 |
| PSMA7 | -1945 | 5883 |
| PSMB1 | -1950 | 2993 |
| PSMB10 | -2749 | 694 |
| PSMB2 | 1564 | -505 |
| PSMB3 | -1740 | 785 |
| PSMB5 | -4005 | 185 |
| PSMB6 | -4401 | 5658 |
| PSMB7 | -4081 | 1594 |
| PSMB8 | 957 | 1753 |
| PSMB9 | 780 | 3070 |
| PSMC1 | 4 | 2250 |
| PSMC3 | -3664 | 4698 |
| PSMC3IP | 4288 | 3394 |
| PSMC4 | -3105 | 1195 |
| PSMC5 | -4013 | 2046 |
| PSMC6 | 3565 | 118 |
| PSMD1 | 2780 | 5566 |
| PSMD11 | 3153 | 2039 |
| PSMD12 | 4564 | 5270 |
| PSMD13 | -2299 | 7835 |
| PSMD14 | 2297 | 3912 |
| PSMD2 | -4119 | 6742 |
| PSMD3 | -3961 | 3075 |
| PSMD4 | -3572 | 1692 |
| PSMD6 | 1330 | 3184 |
| PSMD7 | 1842 | 871 |
| PSMD8 | -3421 | 7774 |
| PSMD9 | -4063 | -186 |
| PSME1 | 1707 | 7235 |
| PSME2 | 3880 | 7233 |
| PSME3 | 685 | 6561 |
| PSME4 | 2755 | 7913 |
| PSMF1 | -1791 | 2268 |
| PTTG1 | 756 | 7447 |
| RAB1A | 2325 | 4344 |
| RAB1B | -4031 | 2589 |
| RAB2A | 2912 | 2863 |
| RAB8A | 2419 | 796 |
| RAD1 | 1778 | 2840 |
| RAD17 | 2171 | 2108 |
| RAD21 | 920 | 2688 |
| RAD50 | 4602 | 179 |
| RAD51 | 4077 | 3959 |
| RAD9A | 947 | 6474 |
| RAD9B | 3824 | -278 |
| RAE1 | -413 | 710 |
| RAN | -1758 | 2287 |
| RANBP2 | 3159 | 4436 |
| RANGAP1 | -2765 | 6695 |
| RB1 | 3165 | 1518 |
| RBBP4 | 474 | 2574 |
| RBBP8 | 4597 | 1067 |
| RBL1 | 927 | 3163 |
| RBL2 | -4249 | 420 |
| RBX1 | 837 | 6226 |
| RCC1 | -4647 | 6687 |
| RCC2 | 728 | 3403 |
| REC8 | 4255 | 342 |
| RFC2 | -1865 | 6031 |
| RFC3 | 397 | 1603 |
| RFC4 | 600 | 4907 |
| RFC5 | 1499 | 7821 |
| RHNO1 | 118 | 8207 |
| RMI2 | 4428 | 4668 |
| RNF168 | 1900 | -440 |
| RNF8 | 2773 | 4447 |
| RPA1 | -3261 | 8080 |
| RPA3 | -460 | 1331 |
| RPS27A | -4637 | 2492 |
| RRM2 | 1384 | 5483 |
| RSF1 | 4150 | 5286 |
| RTEL1 | -574 | 3440 |
| RUVBL1 | -1914 | 6095 |
| RUVBL2 | -3506 | 7969 |
| SDCCAG8 | 1336 | 1961 |
| SEC13 | -2746 | 7357 |
| SEH1L | 2536 | 6644 |
| SET | -85 | 2256 |
| SFN | -1182 | -556 |
| SHQ1 | 264 | 4402 |
| SIRT2 | -3504 | 3540 |
| SKA2 | 3689 | 3206 |
| SKP1 | 2003 | 3193 |
| SKP2 | 4060 | 3439 |
| SMARCA5 | 3732 | 1328 |
| SMC1B | 4199 | -549 |
| SMC2 | 4304 | 1398 |
| SMC3 | 3913 | 4966 |
| SMC4 | 4551 | 3185 |
| SPAST | 3245 | 6893 |
| SPC24 | -272 | 5476 |
| SPDL1 | -2142 | -327 |
| SRC | 831 | -92 |
| SSNA1 | -4591 | 6709 |
| STAG1 | -1499 | 2912 |
| STAG3 | 521 | 3275 |
| SUMO1 | 2185 | 4431 |
| SUN1 | 876 | 659 |
| SUN2 | -4407 | 4929 |
| SYCE2 | 2229 | 2398 |
| SYNE1 | -360 | 8106 |
| SYNE2 | 315 | 217 |
| TAOK1 | 2393 | -212 |
| TEN1 | -3435 | 8321 |
| TERF1 | 2470 | 5033 |
| TERF2 | 587 | 5105 |
| TERF2IP | -2489 | 7036 |
| TERT | 3846 | 733 |
| TFDP1 | 3251 | 471 |
| TFDP2 | -3887 | 3770 |
| TINF2 | -3116 | 4849 |
| TK1 | 338 | -581 |
| TMPO | 3826 | 6701 |
| TNPO1 | 1166 | 4389 |
| TOP2A | 3540 | 4423 |
| TOP3A | 2002 | 4401 |
| TOPBP1 | 3478 | 7075 |
| TP53 | -945 | 1992 |
| TP53BP1 | -432 | 2668 |
| TPR | 3600 | 5135 |
| TPX2 | 1311 | 1461 |
| TUBA1A | -757 | 1542 |
| TUBA1B | 1758 | 3597 |
| TUBA1C | 1849 | 1968 |
| TUBA4A | -2882 | 7151 |
| TUBA4B | 1396 | 3513 |
| TUBB | -1422 | 3715 |
| TUBB2A | 2572 | 4091 |
| TUBB4B | -1484 | 6419 |
| TUBG1 | 701 | 8221 |
| TUBG2 | -1390 | 3395 |
| TUBGCP2 | -2921 | 7827 |
| TUBGCP3 | 1623 | 8013 |
| TUBGCP5 | 4542 | -597 |
| TUBGCP6 | -2196 | 3584 |
| TYMS | 2305 | 3871 |
| UBA52 | -4418 | 4404 |
| UBB | -3237 | 564 |
| UBC | 432 | 2635 |
| UBE2C | -2543 | 1584 |
| UBE2D1 | 2847 | 4705 |
| UBE2E1 | -429 | 3149 |
| UBE2I | -2449 | 3654 |
| UBE2N | 1732 | 6764 |
| UBE2S | 122 | -550 |
| UBE2V2 | 3712 | 5531 |
| UIMC1 | -341 | 7598 |
| USO1 | 4094 | 3166 |
| VPS4A | -4319 | 1747 |
| VRK1 | 2565 | 2415 |
| VRK2 | 4603 | 3132 |
| WEE1 | 1915 | 480 |
| WRAP53 | -4237 | 1879 |
| WRN | 1307 | 7146 |
| XPO1 | 4316 | 5628 |
| YWHAB | 3845 | 4090 |
| YWHAE | 2292 | 6202 |
| YWHAG | -1588 | 5676 |
| YWHAH | 1905 | 3469 |
| YWHAQ | -933 | 1317 |
| YWHAZ | 2673 | 2738 |
| ZW10 | 3610 | 4456 |
| ZWILCH | 4210 | 4734 |
| ZWINT | 1637 | 906 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.1.0
## [2] GGally_2.0.0
## [3] ggplot2_3.3.2
## [4] reshape2_1.4.4
## [5] gtools_3.8.2
## [6] tibble_3.0.1
## [7] dplyr_1.0.0
## [8] echarts4r_0.3.2
## [9] mitch_1.0.6
## [10] FlowSorted.Blood.EPIC_1.6.1
## [11] ExperimentHub_1.14.0
## [12] AnnotationHub_2.20.0
## [13] BiocFileCache_1.12.0
## [14] dbplyr_1.4.4
## [15] nlme_3.1-148
## [16] quadprog_1.5-8
## [17] genefilter_1.70.0
## [18] topconfects_1.4.0
## [19] gplots_3.0.3
## [20] beeswarm_0.2.3
## [21] IlluminaHumanMethylationEPICmanifest_0.3.0
## [22] IlluminaHumanMethylationEPICanno.ilm10b2.hg19_0.6.0
## [23] limma_3.44.3
## [24] missMethyl_1.22.0
## [25] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [26] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.0
## [27] minfi_1.34.0
## [28] bumphunter_1.30.0
## [29] locfit_1.5-9.4
## [30] iterators_1.0.12
## [31] foreach_1.5.0
## [32] Biostrings_2.56.0
## [33] XVector_0.28.0
## [34] SummarizedExperiment_1.18.1
## [35] DelayedArray_0.14.0
## [36] matrixStats_0.56.0
## [37] Biobase_2.48.0
## [38] GenomicRanges_1.40.0
## [39] GenomeInfoDb_1.24.2
## [40] IRanges_2.22.2
## [41] S4Vectors_0.26.1
## [42] BiocGenerics_0.34.0
##
## loaded via a namespace (and not attached):
## [1] backports_1.1.8 plyr_1.8.6
## [3] splines_4.0.2 BiocParallel_1.22.0
## [5] digest_0.6.25 htmltools_0.5.0
## [7] gdata_2.18.0 magrittr_1.5
## [9] memoise_1.1.0 readr_1.3.1
## [11] annotate_1.66.0 askpass_1.1
## [13] siggenes_1.62.0 prettyunits_1.1.1
## [15] colorspace_1.4-1 blob_1.2.1
## [17] rappdirs_0.3.1 xfun_0.15
## [19] jsonlite_1.7.0 crayon_1.3.4
## [21] RCurl_1.98-1.2 GEOquery_2.56.0
## [23] survival_3.2-3 glue_1.4.1
## [25] gtable_0.3.0 zlibbioc_1.34.0
## [27] Rhdf5lib_1.10.0 HDF5Array_1.16.1
## [29] scales_1.1.1 DBI_1.1.0
## [31] rngtools_1.5 Rcpp_1.0.4.6
## [33] xtable_1.8-4 progress_1.2.2
## [35] bit_1.1-15.2 mclust_5.4.6
## [37] preprocessCore_1.50.0 htmlwidgets_1.5.1
## [39] httr_1.4.1 RColorBrewer_1.1-2
## [41] ellipsis_0.3.1 farver_2.0.3
## [43] pkgconfig_2.0.3 reshape_0.8.8
## [45] XML_3.99-0.3 labeling_0.3
## [47] tidyselect_1.1.0 rlang_0.4.6
## [49] later_1.1.0.1 AnnotationDbi_1.50.1
## [51] pbmcapply_1.5.0 munsell_0.5.0
## [53] BiocVersion_3.11.1 tools_4.0.2
## [55] generics_0.0.2 RSQLite_2.2.0
## [57] evaluate_0.14 stringr_1.4.0
## [59] fastmap_1.0.1 yaml_2.2.1
## [61] knitr_1.29 org.Hs.eg.db_3.11.4
## [63] bit64_0.9-7 beanplot_1.2
## [65] caTools_1.18.0 scrime_1.3.5
## [67] purrr_0.3.4 doRNG_1.8.2
## [69] mime_0.9 nor1mix_1.3-0
## [71] xml2_1.3.2 biomaRt_2.44.1
## [73] compiler_4.0.2 curl_4.3
## [75] interactiveDisplayBase_1.26.3 testthat_2.3.2
## [77] statmod_1.4.34 stringi_1.4.6
## [79] highr_0.8 desc_1.2.0
## [81] GenomicFeatures_1.40.0 lattice_0.20-41
## [83] Matrix_1.2-18 multtest_2.44.0
## [85] vctrs_0.3.1 pillar_1.4.4
## [87] lifecycle_0.2.0 BiocManager_1.30.10
## [89] data.table_1.12.8 bitops_1.0-6
## [91] httpuv_1.5.4 rtracklayer_1.48.0
## [93] R6_2.4.1 promises_1.1.1
## [95] gridExtra_2.3 KernSmooth_2.23-17
## [97] codetools_0.2-16 MASS_7.3-51.6
## [99] assertthat_0.2.1 rhdf5_2.32.1
## [101] rprojroot_1.3-2 openssl_1.4.2
## [103] withr_2.2.0 GenomicAlignments_1.24.0
## [105] Rsamtools_2.4.0 GenomeInfoDbData_1.2.3
## [107] hms_0.5.3 grid_4.0.2
## [109] tidyr_1.1.0 base64_2.0
## [111] rmarkdown_2.3 DelayedMatrixStats_1.10.0
## [113] illuminaio_0.30.0 shiny_1.5.0END of report