Mitch Report

date generated: 2020-08-19

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##               RNA        meth
## A1BG   2.62454842 -0.45188238
## AAAS  -2.57494043  0.06143186
## AACS   0.09686573  0.13997068
## AAGAB  1.08711796 -0.59522248
## AAK1  -2.99514827 -0.32725606
## AAMDC  2.30068224 -0.21261544

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	9311
duplicated_genes_present	0
num_profile_genes_in_sets	5535
num_profile_genes_not_in_sets	3776
profile_pearson_correl	-0.10372
profile_spearman_correl	-0.08281

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1280
num_genesets_included	1120

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 398

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.RNA	s.meth	p.RNA	p.meth
Neutrophil degranulation	306	1.47e-53	1.65e-50	0.522	0.5200	-4.82e-02	7.52e-55	1.51e-01
Innate Immune System	617	2.24e-46	1.25e-43	0.347	0.3460	-1.29e-02	1.52e-47	5.93e-01
Immune System	1197	1.78e-29	6.65e-27	0.200	0.1940	4.94e-02	1.21e-27	5.71e-03
Vesicle-mediated transport	442	1.98e-20	5.17e-18	0.266	0.2660	3.47e-05	2.25e-21	9.99e-01
Membrane Trafficking	436	2.31e-20	5.17e-18	0.268	0.2680	-1.37e-04	2.61e-21	9.96e-01
Signal Transduction	1172	3.07e-18	5.73e-16	0.159	0.1570	2.65e-02	3.16e-18	1.41e-01
Signaling by Receptor Tyrosine Kinases	284	8.88e-13	1.42e-10	0.255	0.2510	4.17e-02	4.93e-13	2.30e-01
Disease	871	1.15e-11	1.60e-09	0.141	0.1310	5.29e-02	1.82e-10	1.01e-02
Metabolism of proteins	1263	1.28e-11	1.60e-09	0.119	0.0978	6.72e-02	2.11e-08	1.20e-04
rRNA processing	159	1.71e-11	1.75e-09	0.336	-0.2890	1.71e-01	3.67e-10	2.07e-04
Signaling by Interleukins	262	1.72e-11	1.75e-09	0.252	0.2520	1.62e-02	3.27e-12	6.55e-01
Metabolism	1215	2.40e-11	2.24e-09	0.125	0.1240	-1.53e-02	2.79e-12	3.90e-01
Major pathway of rRNA processing in the nucleolus and cytosol	147	4.74e-11	4.08e-09	0.343	-0.2830	1.93e-01	3.46e-09	5.68e-05
Post-translational protein modification	889	9.73e-11	7.78e-09	0.133	0.1200	5.88e-02	4.08e-09	3.86e-03
rRNA processing in the nucleus and cytosol	154	1.18e-10	8.81e-09	0.328	-0.2750	1.80e-01	4.40e-09	1.29e-04
Gene expression (Transcription)	1007	1.58e-10	1.10e-08	0.128	-0.1280	-8.61e-03	3.06e-11	6.55e-01
Hemostasis	304	1.94e-10	1.28e-08	0.224	0.2240	1.40e-03	2.71e-11	9.67e-01
Diseases of signal transduction by growth factor receptors and second messengers	260	2.05e-10	1.28e-08	0.240	0.2400	1.29e-02	3.64e-11	7.23e-01
Generic Transcription Pathway	803	4.39e-10	2.59e-08	0.136	-0.1290	-4.23e-02	1.28e-09	4.73e-02
Transport of small molecules	342	1.17e-09	6.57e-08	0.205	0.2040	-2.04e-02	1.43e-10	5.22e-01
Platelet activation, signaling and aggregation	133	1.37e-08	7.33e-07	0.297	0.2900	6.25e-02	8.19e-09	2.15e-01
Infectious disease	486	1.72e-08	8.77e-07	0.154	0.1120	1.05e-01	2.88e-05	9.30e-05
Cellular responses to external stimuli	397	2.58e-08	1.26e-06	0.168	0.1220	1.15e-01	3.95e-05	1.00e-04
Asparagine N-linked glycosylation	223	2.83e-08	1.32e-06	0.228	0.2270	2.07e-02	6.33e-09	5.97e-01
EPH-Ephrin signaling	55	4.44e-08	1.99e-06	0.462	0.4480	-1.12e-01	9.50e-09	1.53e-01
RNA Polymerase II Transcription	895	5.89e-08	2.54e-06	0.114	-0.1090	-3.35e-02	7.75e-08	9.91e-02
Metabolism of RNA	535	6.45e-08	2.67e-06	0.154	-0.0920	1.23e-01	3.43e-04	1.72e-06
Influenza Viral RNA Transcription and Replication	110	7.14e-08	2.86e-06	0.330	-0.2250	2.42e-01	4.76e-05	1.27e-05
Cellular responses to stress	392	7.67e-08	2.96e-06	0.163	0.1160	1.14e-01	9.27e-05	1.23e-04
Metabolism of lipids	427	1.01e-07	3.79e-06	0.162	0.1620	-9.59e-03	1.40e-08	7.37e-01
Signaling by NOTCH	130	1.43e-07	5.15e-06	0.286	0.2860	-5.81e-03	2.09e-08	9.09e-01
Signaling by NTRKs	90	1.79e-07	6.28e-06	0.333	0.3250	7.62e-02	1.09e-07	2.13e-01
Influenza Infection	128	2.33e-07	7.92e-06	0.295	-0.1850	2.30e-01	3.09e-04	7.89e-06
Interleukin-1 signaling	78	2.84e-07	9.34e-06	0.358	0.3570	1.53e-02	5.10e-08	8.15e-01
ER to Golgi Anterograde Transport	105	3.05e-07	9.75e-06	0.307	0.3060	2.49e-02	6.47e-08	6.61e-01
tRNA processing	93	3.59e-07	1.12e-05	0.335	-0.3170	1.08e-01	1.34e-07	7.18e-02
Regulation of actin dynamics for phagocytic cup formation	45	5.91e-07	1.79e-05	0.461	0.4610	-1.20e-02	8.93e-08	8.89e-01
Response to elevated platelet cytosolic Ca2+	53	6.98e-07	2.06e-05	0.421	0.4210	6.61e-03	1.17e-07	9.34e-01
Toll-like Receptor Cascades	107	8.29e-07	2.38e-05	0.295	0.2950	5.05e-03	1.40e-07	9.28e-01
Peptide chain elongation	67	9.08e-07	2.54e-05	0.388	-0.2460	3.00e-01	5.05e-04	2.26e-05
Leishmania infection	109	1.03e-06	2.82e-05	0.295	0.2910	-5.20e-02	1.73e-07	3.50e-01
Eukaryotic Translation Elongation	70	1.08e-06	2.89e-05	0.377	-0.2400	2.91e-01	5.37e-04	2.60e-05
Developmental Biology	449	1.11e-06	2.89e-05	0.146	0.1460	-7.32e-03	1.66e-07	7.93e-01
Apoptosis	131	1.40e-06	3.35e-05	0.259	0.2540	4.84e-02	5.52e-07	3.41e-01
Toll Like Receptor 4 (TLR4) Cascade	93	1.43e-06	3.35e-05	0.309	0.3080	2.24e-02	2.97e-07	7.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	1.47e-06	3.35e-05	0.356	0.3560	-7.59e-03	2.30e-07	9.12e-01
Toll Like Receptor 2 (TLR2) Cascade	71	1.47e-06	3.35e-05	0.356	0.3560	-7.59e-03	2.30e-07	9.12e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	1.47e-06	3.35e-05	0.356	0.3560	-7.59e-03	2.30e-07	9.12e-01
Toll Like Receptor TLR6:TLR2 Cascade	71	1.47e-06	3.35e-05	0.356	0.3560	-7.59e-03	2.30e-07	9.12e-01
Programmed Cell Death	134	1.59e-06	3.55e-05	0.255	0.2510	4.59e-02	5.94e-07	3.60e-01

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.RNA	s.meth	p.RNA	p.meth
Neutrophil degranulation	306	1.47e-53	1.65e-50	0.52200	0.520000	-4.82e-02	7.52e-55	1.51e-01
Innate Immune System	617	2.24e-46	1.25e-43	0.34700	0.346000	-1.29e-02	1.52e-47	5.93e-01
Immune System	1197	1.78e-29	6.65e-27	0.20000	0.194000	4.94e-02	1.21e-27	5.71e-03
Vesicle-mediated transport	442	1.98e-20	5.17e-18	0.26600	0.266000	3.47e-05	2.25e-21	9.99e-01
Membrane Trafficking	436	2.31e-20	5.17e-18	0.26800	0.268000	-1.37e-04	2.61e-21	9.96e-01
Signal Transduction	1172	3.07e-18	5.73e-16	0.15900	0.157000	2.65e-02	3.16e-18	1.41e-01
Signaling by Receptor Tyrosine Kinases	284	8.88e-13	1.42e-10	0.25500	0.251000	4.17e-02	4.93e-13	2.30e-01
Disease	871	1.15e-11	1.60e-09	0.14100	0.131000	5.29e-02	1.82e-10	1.01e-02
Metabolism of proteins	1263	1.28e-11	1.60e-09	0.11900	0.097800	6.72e-02	2.11e-08	1.20e-04
rRNA processing	159	1.71e-11	1.75e-09	0.33600	-0.289000	1.71e-01	3.67e-10	2.07e-04
Signaling by Interleukins	262	1.72e-11	1.75e-09	0.25200	0.252000	1.62e-02	3.27e-12	6.55e-01
Metabolism	1215	2.40e-11	2.24e-09	0.12500	0.124000	-1.53e-02	2.79e-12	3.90e-01
Major pathway of rRNA processing in the nucleolus and cytosol	147	4.74e-11	4.08e-09	0.34300	-0.283000	1.93e-01	3.46e-09	5.68e-05
Post-translational protein modification	889	9.73e-11	7.78e-09	0.13300	0.120000	5.88e-02	4.08e-09	3.86e-03
rRNA processing in the nucleus and cytosol	154	1.18e-10	8.81e-09	0.32800	-0.275000	1.80e-01	4.40e-09	1.29e-04
Gene expression (Transcription)	1007	1.58e-10	1.10e-08	0.12800	-0.128000	-8.61e-03	3.06e-11	6.55e-01
Hemostasis	304	1.94e-10	1.28e-08	0.22400	0.224000	1.40e-03	2.71e-11	9.67e-01
Diseases of signal transduction by growth factor receptors and second messengers	260	2.05e-10	1.28e-08	0.24000	0.240000	1.29e-02	3.64e-11	7.23e-01
Generic Transcription Pathway	803	4.39e-10	2.59e-08	0.13600	-0.129000	-4.23e-02	1.28e-09	4.73e-02
Transport of small molecules	342	1.17e-09	6.57e-08	0.20500	0.204000	-2.04e-02	1.43e-10	5.22e-01
Platelet activation, signaling and aggregation	133	1.37e-08	7.33e-07	0.29700	0.290000	6.25e-02	8.19e-09	2.15e-01
Infectious disease	486	1.72e-08	8.77e-07	0.15400	0.112000	1.05e-01	2.88e-05	9.30e-05
Cellular responses to external stimuli	397	2.58e-08	1.26e-06	0.16800	0.122000	1.15e-01	3.95e-05	1.00e-04
Asparagine N-linked glycosylation	223	2.83e-08	1.32e-06	0.22800	0.227000	2.07e-02	6.33e-09	5.97e-01
EPH-Ephrin signaling	55	4.44e-08	1.99e-06	0.46200	0.448000	-1.12e-01	9.50e-09	1.53e-01
RNA Polymerase II Transcription	895	5.89e-08	2.54e-06	0.11400	-0.109000	-3.35e-02	7.75e-08	9.91e-02
Metabolism of RNA	535	6.45e-08	2.67e-06	0.15400	-0.092000	1.23e-01	3.43e-04	1.72e-06
Influenza Viral RNA Transcription and Replication	110	7.14e-08	2.86e-06	0.33000	-0.225000	2.42e-01	4.76e-05	1.27e-05
Cellular responses to stress	392	7.67e-08	2.96e-06	0.16300	0.116000	1.14e-01	9.27e-05	1.23e-04
Metabolism of lipids	427	1.01e-07	3.79e-06	0.16200	0.162000	-9.59e-03	1.40e-08	7.37e-01
Signaling by NOTCH	130	1.43e-07	5.15e-06	0.28600	0.286000	-5.81e-03	2.09e-08	9.09e-01
Signaling by NTRKs	90	1.79e-07	6.28e-06	0.33300	0.325000	7.62e-02	1.09e-07	2.13e-01
Influenza Infection	128	2.33e-07	7.92e-06	0.29500	-0.185000	2.30e-01	3.09e-04	7.89e-06
Interleukin-1 signaling	78	2.84e-07	9.34e-06	0.35800	0.357000	1.53e-02	5.10e-08	8.15e-01
ER to Golgi Anterograde Transport	105	3.05e-07	9.75e-06	0.30700	0.306000	2.49e-02	6.47e-08	6.61e-01
tRNA processing	93	3.59e-07	1.12e-05	0.33500	-0.317000	1.08e-01	1.34e-07	7.18e-02
Regulation of actin dynamics for phagocytic cup formation	45	5.91e-07	1.79e-05	0.46100	0.461000	-1.20e-02	8.93e-08	8.89e-01
Response to elevated platelet cytosolic Ca2+	53	6.98e-07	2.06e-05	0.42100	0.421000	6.61e-03	1.17e-07	9.34e-01
Toll-like Receptor Cascades	107	8.29e-07	2.38e-05	0.29500	0.295000	5.05e-03	1.40e-07	9.28e-01
Peptide chain elongation	67	9.08e-07	2.54e-05	0.38800	-0.246000	3.00e-01	5.05e-04	2.26e-05
Leishmania infection	109	1.03e-06	2.82e-05	0.29500	0.291000	-5.20e-02	1.73e-07	3.50e-01
Eukaryotic Translation Elongation	70	1.08e-06	2.89e-05	0.37700	-0.240000	2.91e-01	5.37e-04	2.60e-05
Developmental Biology	449	1.11e-06	2.89e-05	0.14600	0.146000	-7.32e-03	1.66e-07	7.93e-01
Apoptosis	131	1.40e-06	3.35e-05	0.25900	0.254000	4.84e-02	5.52e-07	3.41e-01
Toll Like Receptor 4 (TLR4) Cascade	93	1.43e-06	3.35e-05	0.30900	0.308000	2.24e-02	2.97e-07	7.09e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	71	1.47e-06	3.35e-05	0.35600	0.356000	-7.59e-03	2.30e-07	9.12e-01
Toll Like Receptor 2 (TLR2) Cascade	71	1.47e-06	3.35e-05	0.35600	0.356000	-7.59e-03	2.30e-07	9.12e-01
Toll Like Receptor TLR1:TLR2 Cascade	71	1.47e-06	3.35e-05	0.35600	0.356000	-7.59e-03	2.30e-07	9.12e-01
Toll Like Receptor TLR6:TLR2 Cascade	71	1.47e-06	3.35e-05	0.35600	0.356000	-7.59e-03	2.30e-07	9.12e-01
Programmed Cell Death	134	1.59e-06	3.55e-05	0.25500	0.251000	4.59e-02	5.94e-07	3.60e-01
Clathrin-mediated endocytosis	90	1.73e-06	3.81e-05	0.31200	0.312000	1.85e-02	3.41e-07	7.63e-01
Platelet degranulation	49	1.83e-06	3.94e-05	0.42200	0.421000	1.82e-02	3.40e-07	8.26e-01
Signaling by NTRK1 (TRKA)	82	2.26e-06	4.76e-05	0.32100	0.316000	5.45e-02	7.84e-07	3.95e-01
MHC class II antigen presentation	70	2.29e-06	4.76e-05	0.36000	0.345000	-1.02e-01	6.20e-07	1.42e-01
Detoxification of Reactive Oxygen Species	23	2.45e-06	5.00e-05	0.61800	0.611000	-9.37e-02	3.97e-07	4.37e-01
MAPK family signaling cascades	185	2.78e-06	5.56e-05	0.20800	0.176000	1.12e-01	4.07e-05	9.18e-03
Interleukin-1 family signaling	97	2.89e-06	5.62e-05	0.29800	0.297000	-1.48e-02	4.47e-07	8.02e-01
PIP3 activates AKT signaling	179	2.91e-06	5.62e-05	0.21200	0.191000	9.19e-02	1.10e-05	3.50e-02
Transport to the Golgi and subsequent modification	127	3.30e-06	6.26e-05	0.25800	0.258000	5.22e-03	5.80e-07	9.19e-01
Formation of a pool of free 40S subunits	76	3.97e-06	7.40e-05	0.34400	-0.189000	2.87e-01	4.41e-03	1.59e-05
Eukaryotic Translation Termination	70	4.11e-06	7.55e-05	0.35800	-0.221000	2.82e-01	1.39e-03	4.73e-05
Selenocysteine synthesis	68	5.10e-06	9.21e-05	0.36100	-0.250000	2.60e-01	3.77e-04	2.11e-04
Cytokine Signaling in Immune system	496	5.57e-06	9.90e-05	0.12500	0.094800	8.23e-02	3.75e-04	2.01e-03
MyD88 cascade initiated on plasma membrane	65	5.94e-06	1.01e-04	0.34700	0.344000	4.75e-02	1.67e-06	5.09e-01
Toll Like Receptor 10 (TLR10) Cascade	65	5.94e-06	1.01e-04	0.34700	0.344000	4.75e-02	1.67e-06	5.09e-01
Toll Like Receptor 5 (TLR5) Cascade	65	5.94e-06	1.01e-04	0.34700	0.344000	4.75e-02	1.67e-06	5.09e-01
Viral mRNA Translation	67	6.13e-06	1.02e-04	0.36000	-0.223000	2.83e-01	1.65e-03	6.29e-05
COPI-mediated anterograde transport	68	6.18e-06	1.02e-04	0.34000	0.339000	3.17e-02	1.42e-06	6.52e-01
Activation of the pre-replicative complex	28	6.48e-06	1.05e-04	0.55200	-0.480000	2.72e-01	1.10e-05	1.27e-02
Autophagy	104	7.10e-06	1.12e-04	0.27700	0.277000	-1.07e-02	1.15e-06	8.50e-01
Activation of ATR in response to replication stress	34	7.13e-06	1.12e-04	0.49800	-0.445000	2.24e-01	7.33e-06	2.38e-02
Golgi-to-ER retrograde transport	92	7.48e-06	1.16e-04	0.29100	0.290000	2.34e-02	1.63e-06	6.99e-01
trans-Golgi Network Vesicle Budding	52	7.78e-06	1.19e-04	0.39800	0.378000	-1.25e-01	2.53e-06	1.18e-01
Intracellular signaling by second messengers	204	8.42e-06	1.27e-04	0.19200	0.182000	6.25e-02	8.87e-06	1.26e-01
RHO GTPases Activate WASPs and WAVEs	29	8.63e-06	1.29e-04	0.51900	0.518000	-3.09e-02	1.38e-06	7.73e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	155	9.05e-06	1.33e-04	0.22400	0.223000	1.06e-02	1.76e-06	8.21e-01
Adaptive Immune System	474	9.53e-06	1.37e-04	0.12600	0.105000	6.86e-02	1.09e-04	1.17e-02
DNA strand elongation	27	9.54e-06	1.37e-04	0.55000	-0.503000	2.21e-01	5.99e-06	4.67e-02
SRP-dependent cotranslational protein targeting to membrane	85	9.73e-06	1.38e-04	0.31100	-0.125000	2.84e-01	4.70e-02	6.09e-06
MAP2K and MAPK activation	25	1.13e-05	1.58e-04	0.53600	0.506000	1.77e-01	1.20e-05	1.26e-01
Signaling by WNT	174	1.24e-05	1.71e-04	0.20400	0.195000	6.25e-02	1.06e-05	1.57e-01
RAB geranylgeranylation	39	1.34e-05	1.83e-04	0.42500	0.391000	1.66e-01	2.45e-05	7.28e-02
ROS and RNS production in phagocytes	23	1.37e-05	1.84e-04	0.57300	0.570000	-5.56e-02	2.22e-06	6.44e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	66	1.43e-05	1.88e-04	0.33200	0.328000	4.83e-02	4.17e-06	4.98e-01
Cellular response to hypoxia	60	1.43e-05	1.88e-04	0.35000	0.350000	1.77e-02	2.84e-06	8.13e-01
MAPK1/MAPK3 signaling	160	1.85e-05	2.41e-04	0.20600	0.170000	1.17e-01	2.17e-04	1.14e-02
FCGR3A-mediated phagocytosis	43	2.04e-05	2.56e-04	0.41000	0.410000	-1.40e-02	3.44e-06	8.74e-01
Leishmania phagocytosis	43	2.04e-05	2.56e-04	0.41000	0.410000	-1.40e-02	3.44e-06	8.74e-01
Parasite infection	43	2.04e-05	2.56e-04	0.41000	0.410000	-1.40e-02	3.44e-06	8.74e-01
MyD88 dependent cascade initiated on endosome	67	2.50e-05	3.08e-04	0.32000	0.314000	5.97e-02	8.98e-06	3.99e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade	67	2.50e-05	3.08e-04	0.32000	0.314000	5.97e-02	8.98e-06	3.99e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	72	2.56e-05	3.11e-04	0.32600	-0.197000	2.60e-01	3.94e-03	1.40e-04
GTP hydrolysis and joining of the 60S ribosomal subunit	86	3.19e-05	3.84e-04	0.29300	-0.132000	2.62e-01	3.48e-02	2.77e-05
RAB GEFs exchange GTP for GDP on RABs	61	3.31e-05	3.95e-04	0.32800	0.311000	1.03e-01	2.73e-05	1.65e-01
RAF/MAP kinase cascade	155	3.49e-05	4.12e-04	0.20300	0.159000	1.26e-01	6.74e-04	6.92e-03
L1CAM interactions	40	3.55e-05	4.14e-04	0.41700	0.413000	-5.59e-02	6.16e-06	5.41e-01
Toll Like Receptor 9 (TLR9) Cascade	70	4.20e-05	4.85e-04	0.30500	0.300000	5.54e-02	1.45e-05	4.24e-01
COPI-independent Golgi-to-ER retrograde traffic	28	4.91e-05	5.61e-04	0.48600	0.486000	-1.45e-02	8.65e-06	8.94e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency	76	4.99e-05	5.64e-04	0.30800	-0.200000	2.34e-01	2.59e-03	4.42e-04
tRNA processing in the nucleus	55	5.07e-05	5.67e-04	0.35900	-0.312000	1.78e-01	6.55e-05	2.24e-02
Nervous system development	306	5.40e-05	5.99e-04	0.14700	0.147000	9.59e-03	1.16e-05	7.75e-01
L13a-mediated translational silencing of Ceruloplasmin expression	85	6.17e-05	6.72e-04	0.28600	-0.127000	2.56e-01	4.34e-02	4.79e-05
Macroautophagy	95	6.18e-05	6.72e-04	0.26100	0.261000	-7.97e-04	1.14e-05	9.89e-01
Axon guidance	294	6.56e-05	7.07e-04	0.14900	0.149000	8.51e-03	1.38e-05	8.04e-01
Fcgamma receptor (FCGR) dependent phagocytosis	63	6.63e-05	7.08e-04	0.32200	0.320000	-4.09e-02	1.18e-05	5.75e-01
Golgi Associated Vesicle Biogenesis	39	6.87e-05	7.22e-04	0.41500	0.390000	-1.43e-01	2.54e-05	1.23e-01
FLT3 Signaling	166	6.90e-05	7.22e-04	0.19000	0.153000	1.12e-01	7.02e-04	1.32e-02
rRNA modification in the nucleus and cytosol	47	7.22e-05	7.49e-04	0.37400	-0.365000	7.77e-02	1.49e-05	3.58e-01
Rab regulation of trafficking	89	7.69e-05	7.90e-04	0.26200	0.255000	5.90e-02	3.30e-05	3.38e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	77	8.00e-05	8.15e-04	0.28000	0.269000	7.64e-02	4.57e-05	2.48e-01
Selenoamino acid metabolism	76	8.16e-05	8.23e-04	0.30000	-0.201000	2.22e-01	2.45e-03	8.22e-04
Cap-dependent Translation Initiation	93	8.54e-05	8.46e-04	0.26800	-0.118000	2.41e-01	4.95e-02	6.17e-05
Eukaryotic Translation Initiation	93	8.54e-05	8.46e-04	0.26800	-0.118000	2.41e-01	4.95e-02	6.17e-05
Antigen processing-Cross presentation	76	9.45e-05	9.28e-04	0.28500	0.285000	1.27e-03	1.80e-05	9.85e-01
Cargo recognition for clathrin-mediated endocytosis	65	9.81e-05	9.55e-04	0.30400	0.300000	4.84e-02	3.01e-05	5.00e-01
Regulation of PTEN stability and activity	56	1.05e-04	1.02e-03	0.32400	0.314000	7.95e-02	5.01e-05	3.04e-01
Unwinding of DNA	10	1.07e-04	1.02e-03	0.81000	-0.679000	4.41e-01	2.02e-04	1.57e-02
Signaling by NOTCH1	51	1.12e-04	1.06e-03	0.35100	0.342000	-8.15e-02	2.50e-05	3.15e-01
EPHB-mediated forward signaling	24	1.16e-04	1.09e-03	0.50200	0.502000	-2.08e-02	2.11e-05	8.60e-01
Rev-mediated nuclear export of HIV RNA	33	1.18e-04	1.10e-03	0.44400	-0.365000	2.53e-01	2.89e-04	1.18e-02
Signaling by BRAF and RAF fusions	42	1.29e-04	1.20e-03	0.36900	0.356000	9.68e-02	6.72e-05	2.78e-01
Oncogenic MAPK signaling	56	1.31e-04	1.21e-03	0.32200	0.318000	4.82e-02	3.86e-05	5.33e-01
NS1 Mediated Effects on Host Pathways	38	1.47e-04	1.34e-03	0.40900	-0.338000	2.29e-01	3.10e-04	1.45e-02
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	53	1.50e-04	1.36e-03	0.33000	0.328000	3.19e-02	3.64e-05	6.88e-01
PTEN Regulation	114	1.63e-04	1.46e-03	0.22100	0.209000	7.11e-02	1.20e-04	1.92e-01
Interferon alpha/beta signaling	49	1.66e-04	1.48e-03	0.35600	-0.316000	1.65e-01	1.35e-04	4.64e-02
Signaling by high-kinase activity BRAF mutants	22	1.78e-04	1.57e-03	0.50100	0.490000	1.09e-01	7.08e-05	3.77e-01
Signaling by NOTCH4	68	1.90e-04	1.66e-03	0.29200	0.291000	-2.09e-02	3.48e-05	7.66e-01
Interactions of Rev with host cellular proteins	34	1.93e-04	1.67e-03	0.42600	-0.348000	2.46e-01	4.55e-04	1.33e-02
MyD88-independent TLR4 cascade	75	1.95e-04	1.67e-03	0.27000	0.259000	7.53e-02	1.09e-04	2.61e-01
TRIF(TICAM1)-mediated TLR4 signaling	75	1.95e-04	1.67e-03	0.27000	0.259000	7.53e-02	1.09e-04	2.61e-01
DNA Repair	238	1.97e-04	1.67e-03	0.16000	-0.153000	4.62e-02	5.49e-05	2.23e-01
Chromatin modifying enzymes	150	2.03e-04	1.69e-03	0.20100	-0.068900	1.88e-01	1.47e-01	7.27e-05
Chromatin organization	150	2.03e-04	1.69e-03	0.20100	-0.068900	1.88e-01	1.47e-01	7.27e-05
Endosomal Sorting Complex Required For Transport (ESCRT)	27	2.04e-04	1.70e-03	0.45000	0.443000	8.18e-02	6.87e-05	4.62e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	86	2.10e-04	1.72e-03	0.26700	-0.152000	2.20e-01	1.54e-02	4.40e-04
Nonsense-Mediated Decay (NMD)	86	2.10e-04	1.72e-03	0.26700	-0.152000	2.20e-01	1.54e-02	4.40e-04
Defective CFTR causes cystic fibrosis	52	2.12e-04	1.72e-03	0.32500	0.321000	4.94e-02	6.29e-05	5.38e-01
PCP/CE pathway	71	2.15e-04	1.73e-03	0.28300	0.282000	-1.37e-02	4.00e-05	8.42e-01
Peptide ligand-binding receptors	16	2.16e-04	1.73e-03	0.61300	0.539000	-2.91e-01	1.89e-04	4.38e-02
ER-Phagosome pathway	68	2.18e-04	1.73e-03	0.28300	0.278000	5.28e-02	7.47e-05	4.53e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	46	2.34e-04	1.83e-03	0.34300	0.339000	5.37e-02	7.04e-05	5.29e-01
Insulin receptor recycling	17	2.35e-04	1.83e-03	0.57200	0.572000	-2.03e-02	4.44e-05	8.85e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	20	2.36e-04	1.83e-03	0.52300	0.521000	4.46e-02	5.59e-05	7.30e-01
Neurodegenerative Diseases	20	2.36e-04	1.83e-03	0.52300	0.521000	4.46e-02	5.59e-05	7.30e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	10	2.41e-04	1.84e-03	0.76400	0.716000	-2.66e-01	8.85e-05	1.45e-01
alpha-linolenic acid (ALA) metabolism	10	2.41e-04	1.84e-03	0.76400	0.716000	-2.66e-01	8.85e-05	1.45e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	47	2.60e-04	1.97e-03	0.33800	0.336000	4.17e-02	6.95e-05	6.21e-01
MAPK6/MAPK4 signaling	67	2.73e-04	2.05e-03	0.28100	0.274000	6.15e-02	1.08e-04	3.85e-01
Class I MHC mediated antigen processing & presentation	281	2.87e-04	2.14e-03	0.13700	0.128000	4.80e-02	2.41e-04	1.70e-01
Hedgehog ligand biogenesis	51	2.96e-04	2.20e-03	0.32300	0.322000	3.07e-02	7.24e-05	7.05e-01
Fc epsilon receptor (FCERI) signaling	109	3.15e-04	2.32e-03	0.21800	0.212000	5.35e-02	1.41e-04	3.36e-01
Degradation of beta-catenin by the destruction complex	68	3.40e-04	2.49e-03	0.27400	0.262000	7.92e-02	1.93e-04	2.60e-01
SARS-CoV Infections	69	3.55e-04	2.58e-03	0.26600	0.208000	1.67e-01	2.87e-03	1.69e-02
Homologous DNA Pairing and Strand Exchange	38	3.62e-04	2.61e-03	0.38000	-0.367000	1.01e-01	9.28e-05	2.81e-01
Regulation of ornithine decarboxylase (ODC)	43	3.66e-04	2.62e-03	0.34600	0.344000	4.18e-02	9.74e-05	6.35e-01
Interactions of Vpr with host cellular proteins	33	3.68e-04	2.62e-03	0.41400	-0.358000	2.07e-01	3.69e-04	3.96e-02
Gene Silencing by RNA	58	3.70e-04	2.62e-03	0.31500	-0.219000	2.25e-01	3.92e-03	3.03e-03
Signaling by RAF1 mutants	25	3.74e-04	2.63e-03	0.45000	0.442000	8.93e-02	1.34e-04	4.40e-01
ABC transporter disorders	56	3.80e-04	2.66e-03	0.30600	0.306000	2.57e-03	7.74e-05	9.74e-01
SUMOylation	137	3.88e-04	2.70e-03	0.20400	-0.115000	1.69e-01	2.05e-02	6.83e-04
Negative regulation of MET activity	16	4.08e-04	2.82e-03	0.54700	0.420000	3.50e-01	3.66e-03	1.53e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	33	4.13e-04	2.84e-03	0.40000	0.397000	-5.24e-02	8.04e-05	6.03e-01
NEP/NS2 Interacts with the Cellular Export Machinery	30	4.16e-04	2.84e-03	0.43200	-0.353000	2.50e-01	8.38e-04	1.78e-02
Fanconi Anemia Pathway	28	4.19e-04	2.84e-03	0.43300	-0.431000	4.11e-02	8.02e-05	7.07e-01
Post-translational protein phosphorylation	32	4.35e-04	2.93e-03	0.40300	0.402000	-2.28e-02	8.38e-05	8.23e-01
Semaphorin interactions	39	5.03e-04	3.38e-03	0.36500	0.359000	-6.98e-02	1.07e-04	4.51e-01
COPII-mediated vesicle transport	51	5.29e-04	3.51e-03	0.30900	0.304000	5.64e-02	1.76e-04	4.86e-01
Hyaluronan uptake and degradation	10	5.30e-04	3.51e-03	0.73100	0.660000	-3.15e-01	3.05e-04	8.48e-02
Signaling by Rho GTPases	258	5.58e-04	3.68e-03	0.13700	0.129000	4.61e-02	4.00e-04	2.06e-01
Budding and maturation of HIV virion	24	5.69e-04	3.73e-03	0.45600	0.456000	-2.15e-02	1.12e-04	8.55e-01
CLEC7A (Dectin-1) signaling	84	5.91e-04	3.85e-03	0.24100	0.240000	2.60e-02	1.53e-04	6.81e-01
Interferon Signaling	142	6.05e-04	3.91e-03	0.19500	-0.151000	1.23e-01	1.93e-03	1.14e-02
Hh mutants abrogate ligand secretion	48	6.46e-04	4.16e-03	0.31700	0.316000	2.62e-02	1.56e-04	7.54e-01
RHO GTPases Activate ROCKs	13	6.65e-04	4.26e-03	0.60300	0.597000	8.86e-02	1.94e-04	5.80e-01
Smooth Muscle Contraction	19	6.71e-04	4.27e-03	0.52600	0.422000	-3.15e-01	1.46e-03	1.76e-02
Hyaluronan metabolism	11	6.80e-04	4.30e-03	0.68500	0.620000	-2.91e-01	3.70e-04	9.46e-02
Respiratory electron transport	79	6.84e-04	4.31e-03	0.25500	0.239000	-8.87e-02	2.45e-04	1.74e-01
RHO GTPase Effectors	184	7.00e-04	4.38e-03	0.15900	0.146000	6.17e-02	6.75e-04	1.51e-01
Toll Like Receptor 3 (TLR3) Cascade	75	7.05e-04	4.39e-03	0.24900	0.240000	6.51e-02	3.31e-04	3.31e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	42	7.16e-04	4.43e-03	0.33400	0.330000	5.31e-02	2.18e-04	5.52e-01
Degradation of the extracellular matrix	35	7.22e-04	4.43e-03	0.36800	0.368000	2.57e-02	1.70e-04	7.93e-01
Arachidonic acid metabolism	20	7.23e-04	4.43e-03	0.50900	0.263000	-4.35e-01	4.19e-02	7.52e-04
Antiviral mechanism by IFN-stimulated genes	77	7.34e-04	4.45e-03	0.26000	-0.214000	1.48e-01	1.20e-03	2.48e-02
Beta-catenin independent WNT signaling	105	7.44e-04	4.45e-03	0.21300	0.213000	1.35e-02	1.73e-04	8.12e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	28	7.44e-04	4.45e-03	0.43000	-0.362000	2.32e-01	9.35e-04	3.36e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	28	7.44e-04	4.45e-03	0.43000	-0.362000	2.32e-01	9.35e-04	3.36e-02
Vpr-mediated nuclear import of PICs	32	7.47e-04	4.45e-03	0.40200	-0.341000	2.13e-01	8.64e-04	3.71e-02
Translation	234	7.60e-04	4.51e-03	0.14900	-0.065600	1.34e-01	8.64e-02	4.48e-04
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	80	7.66e-04	4.52e-03	0.25100	0.238000	-8.10e-02	2.45e-04	2.12e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR)	32	7.76e-04	4.55e-03	0.38200	0.379000	4.50e-02	2.08e-04	6.60e-01
Signaling by MET	42	7.82e-04	4.55e-03	0.32600	0.292000	1.45e-01	1.07e-03	1.05e-01
Degradation of DVL	48	7.84e-04	4.55e-03	0.31100	0.306000	5.17e-02	2.45e-04	5.36e-01
Neddylation	179	7.87e-04	4.55e-03	0.15800	0.136000	8.06e-02	1.74e-03	6.42e-02
Degradation of GLI2 by the proteasome	50	8.30e-04	4.74e-03	0.30300	0.300000	4.64e-02	2.48e-04	5.71e-01
GLI3 is processed to GLI3R by the proteasome	50	8.30e-04	4.74e-03	0.30300	0.300000	4.64e-02	2.48e-04	5.71e-01
Interleukin-17 signaling	53	8.33e-04	4.74e-03	0.29400	0.289000	5.56e-02	2.84e-04	4.85e-01
Diseases of programmed cell death	22	8.83e-04	4.98e-03	0.45900	0.459000	1.35e-02	1.94e-04	9.13e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF	29	8.99e-04	4.98e-03	0.39500	0.389000	6.80e-02	2.87e-04	5.26e-01
Signaling by RAS mutants	29	8.99e-04	4.98e-03	0.39500	0.389000	6.80e-02	2.87e-04	5.26e-01
Signaling by moderate kinase activity BRAF mutants	29	8.99e-04	4.98e-03	0.39500	0.389000	6.80e-02	2.87e-04	5.26e-01
Signaling downstream of RAS mutants	29	8.99e-04	4.98e-03	0.39500	0.389000	6.80e-02	2.87e-04	5.26e-01
Nuclear import of Rev protein	31	9.13e-04	5.01e-03	0.40300	-0.328000	2.35e-01	1.60e-03	2.37e-02
C-type lectin receptors (CLRs)	100	9.13e-04	5.01e-03	0.21400	0.213000	2.31e-02	2.38e-04	6.91e-01
Signal transduction by L1	11	9.29e-04	5.08e-03	0.65300	0.651000	-5.67e-02	1.86e-04	7.45e-01
MAP kinase activation	50	1.00e-03	5.44e-03	0.29900	0.293000	5.67e-02	3.41e-04	4.88e-01
Presynaptic phase of homologous DNA pairing and strand exchange	35	1.04e-03	5.62e-03	0.37200	-0.343000	1.44e-01	4.43e-04	1.42e-01
Metabolism of non-coding RNA	47	1.06e-03	5.68e-03	0.32300	-0.277000	1.67e-01	1.04e-03	4.77e-02
snRNP Assembly	47	1.06e-03	5.68e-03	0.32300	-0.277000	1.67e-01	1.04e-03	4.77e-02
HATs acetylate histones	58	1.12e-03	5.99e-03	0.29100	-0.170000	2.36e-01	2.53e-02	1.91e-03
Glycerophospholipid biosynthesis	71	1.15e-03	6.10e-03	0.25300	0.253000	-1.10e-02	2.36e-04	8.73e-01
Degradation of GLI1 by the proteasome	51	1.16e-03	6.11e-03	0.29500	0.293000	2.86e-02	2.97e-04	7.24e-01
Late endosomal microautophagy	23	1.16e-03	6.11e-03	0.44000	0.440000	1.77e-02	2.64e-04	8.83e-01
Transport of bile salts and organic acids, metal ions and amine compounds	30	1.20e-03	6.28e-03	0.38900	0.387000	-3.26e-02	2.45e-04	7.58e-01
Hedgehog 'on' state	61	1.21e-03	6.29e-03	0.26900	0.268000	2.35e-02	3.02e-04	7.51e-01
Resolution of Abasic Sites (AP sites)	30	1.24e-03	6.42e-03	0.38500	-0.385000	-3.46e-03	2.70e-04	9.74e-01
Vif-mediated degradation of APOBEC3G	43	1.24e-03	6.42e-03	0.31700	0.313000	5.07e-02	3.82e-04	5.66e-01
SUMO E3 ligases SUMOylate target proteins	131	1.30e-03	6.66e-03	0.19200	-0.109000	1.58e-01	3.24e-02	1.82e-03
Cell Cycle	516	1.30e-03	6.66e-03	0.09880	-0.054200	8.26e-02	3.84e-02	1.58e-03
RHO GTPases activate PKNs	25	1.33e-03	6.77e-03	0.40600	0.359000	1.89e-01	1.90e-03	1.03e-01
SLC-mediated transmembrane transport	97	1.34e-03	6.77e-03	0.22300	0.172000	-1.42e-01	3.50e-03	1.62e-02
FCERI mediated NF-kB activation	64	1.36e-03	6.88e-03	0.25400	0.232000	1.04e-01	1.36e-03	1.49e-01
Transferrin endocytosis and recycling	19	1.38e-03	6.93e-03	0.48600	0.480000	-7.60e-02	2.96e-04	5.66e-01
Signaling by GPCR	229	1.40e-03	6.97e-03	0.14300	0.138000	-3.74e-02	3.68e-04	3.33e-01
Regulation of Apoptosis	45	1.40e-03	6.97e-03	0.30800	0.306000	4.11e-02	3.97e-04	6.34e-01
Export of Viral Ribonucleoproteins from Nucleus	31	1.47e-03	7.27e-03	0.39000	-0.314000	2.30e-01	2.49e-03	2.66e-02
Negative regulation of NOTCH4 signaling	48	1.49e-03	7.37e-03	0.29900	0.299000	1.03e-02	3.40e-04	9.02e-01
TCF dependent signaling in response to WNT	117	1.54e-03	7.55e-03	0.18800	0.176000	6.44e-02	1.03e-03	2.31e-01
Uptake and function of anthrax toxins	10	1.58e-03	7.71e-03	0.65500	0.655000	-1.22e-02	3.37e-04	9.47e-01
NIK-->noncanonical NF-kB signaling	51	1.64e-03	8.00e-03	0.28700	0.287000	2.16e-02	4.06e-04	7.90e-01
Regulation of HSF1-mediated heat shock response	66	1.65e-03	8.00e-03	0.26200	-0.105000	2.41e-01	1.42e-01	7.37e-04
GPCR downstream signalling	214	1.70e-03	8.18e-03	0.14400	0.142000	-2.59e-02	3.80e-04	5.17e-01
Dectin-1 mediated noncanonical NF-kB signaling	52	1.70e-03	8.18e-03	0.28300	0.280000	3.87e-02	4.90e-04	6.30e-01
The citric acid (TCA) cycle and respiratory electron transport	118	1.85e-03	8.86e-03	0.19100	0.190000	-2.40e-02	3.94e-04	6.54e-01
Transport of Ribonucleoproteins into the Host Nucleus	30	1.86e-03	8.87e-03	0.38800	-0.326000	2.11e-01	2.04e-03	4.57e-02
DNA Double-Strand Break Repair	112	1.92e-03	9.11e-03	0.19700	-0.191000	4.84e-02	4.89e-04	3.78e-01
TP53 Regulates Transcription of DNA Repair Genes	51	1.95e-03	9.13e-03	0.29700	-0.158000	2.51e-01	5.12e-02	1.96e-03
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	44	1.96e-03	9.13e-03	0.30200	0.294000	6.82e-02	7.58e-04	4.34e-01
p53-Independent DNA Damage Response	44	1.96e-03	9.13e-03	0.30200	0.294000	6.82e-02	7.58e-04	4.34e-01
p53-Independent G1/S DNA damage checkpoint	44	1.96e-03	9.13e-03	0.30200	0.294000	6.82e-02	7.58e-04	4.34e-01
Chromosome Maintenance	74	2.12e-03	9.85e-03	0.23900	-0.235000	4.59e-02	4.89e-04	4.96e-01
Integration of energy metabolism	58	2.19e-03	1.01e-02	0.27000	0.264000	-5.52e-02	5.16e-04	4.68e-01
CD28 dependent PI3K/Akt signaling	18	2.19e-03	1.01e-02	0.49400	-0.273000	4.12e-01	4.53e-02	2.48e-03
Cross-presentation of soluble exogenous antigens (endosomes)	38	2.20e-03	1.01e-02	0.32500	0.324000	2.71e-02	5.60e-04	7.73e-01
Signaling by Insulin receptor	42	2.22e-03	1.01e-02	0.30800	0.305000	4.05e-02	6.33e-04	6.50e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	46	2.27e-03	1.02e-02	0.29400	0.293000	3.05e-02	6.03e-04	7.21e-01
Amino acids regulate mTORC1	43	2.27e-03	1.02e-02	0.30600	0.305000	1.60e-02	5.44e-04	8.56e-01
PI3K/AKT Signaling in Cancer	48	2.27e-03	1.02e-02	0.28000	0.161000	2.29e-01	5.35e-02	6.21e-03
TCR signaling	88	2.28e-03	1.03e-02	0.20700	0.160000	1.31e-01	9.58e-03	3.46e-02
Phospholipid metabolism	129	2.35e-03	1.05e-02	0.17500	0.173000	2.65e-02	7.10e-04	6.04e-01
Signalling to ERKs	26	2.42e-03	1.08e-02	0.38100	0.354000	1.41e-01	1.77e-03	2.13e-01
Cellular response to heat stress	79	2.43e-03	1.08e-02	0.23200	-0.087300	2.15e-01	1.81e-01	9.63e-04
TP53 Regulates Metabolic Genes	72	2.46e-03	1.09e-02	0.24200	0.228000	-8.10e-02	8.23e-04	2.36e-01
Lysosome Vesicle Biogenesis	25	2.49e-03	1.10e-02	0.41100	0.379000	-1.59e-01	1.03e-03	1.69e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	41	2.58e-03	1.12e-02	0.31700	0.307000	-7.89e-02	6.72e-04	3.82e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	41	2.58e-03	1.12e-02	0.31700	0.307000	-7.89e-02	6.72e-04	3.82e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	41	2.58e-03	1.12e-02	0.31700	0.307000	-7.89e-02	6.72e-04	3.82e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	41	2.58e-03	1.12e-02	0.31700	0.307000	-7.89e-02	6.72e-04	3.82e-01
Signaling by NOTCH1 in Cancer	41	2.58e-03	1.12e-02	0.31700	0.307000	-7.89e-02	6.72e-04	3.82e-01
Transport of the SLBP independent Mature mRNA	33	2.62e-03	1.13e-02	0.36000	-0.304000	1.93e-01	2.55e-03	5.58e-02
HIV Infection	188	2.71e-03	1.16e-02	0.14000	0.082300	1.14e-01	5.30e-02	7.54e-03
The role of GTSE1 in G2/M progression after G2 checkpoint	52	2.75e-03	1.18e-02	0.27300	0.272000	2.34e-02	7.11e-04	7.70e-01
Cargo concentration in the ER	20	2.78e-03	1.19e-02	0.44300	0.443000	-2.12e-02	6.07e-04	8.70e-01
Ion channel transport	80	2.88e-03	1.22e-02	0.22000	0.220000	9.99e-03	6.93e-04	8.78e-01
Downstream TCR signaling	72	2.90e-03	1.22e-02	0.22400	0.185000	1.27e-01	6.85e-03	6.29e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	19	2.92e-03	1.23e-02	0.45500	0.453000	-4.40e-02	6.34e-04	7.40e-01
Vpu mediated degradation of CD4	44	2.94e-03	1.23e-02	0.29400	0.292000	3.66e-02	8.31e-04	6.75e-01
Activated NOTCH1 Transmits Signal to the Nucleus	19	2.95e-03	1.23e-02	0.44400	0.436000	8.39e-02	1.00e-03	5.27e-01
PPARA activates gene expression	79	2.97e-03	1.23e-02	0.21600	0.204000	7.12e-02	1.74e-03	2.75e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	20	3.00e-03	1.24e-02	0.43500	-0.433000	-4.24e-02	7.96e-04	7.43e-01
ABC-family proteins mediated transport	72	3.11e-03	1.28e-02	0.22900	0.226000	3.39e-02	9.36e-04	6.19e-01
Processing of Capped Intron-Containing Pre-mRNA	191	3.19e-03	1.31e-02	0.14700	-0.053600	1.37e-01	2.04e-01	1.20e-03
Nuclear Events (kinase and transcription factor activation)	43	3.25e-03	1.33e-02	0.29200	0.281000	7.73e-02	1.44e-03	3.81e-01
AKT phosphorylates targets in the cytosol	13	3.26e-03	1.33e-02	0.52300	0.464000	2.41e-01	3.77e-03	1.33e-01
MTOR signalling	36	3.36e-03	1.37e-02	0.32100	0.317000	4.50e-02	9.93e-04	6.41e-01
InlB-mediated entry of Listeria monocytogenes into host cell	11	3.41e-03	1.38e-02	0.56300	0.432000	3.60e-01	1.31e-02	3.87e-02
HDR through Homologous Recombination (HRR)	58	3.46e-03	1.40e-02	0.25800	-0.256000	3.40e-02	7.74e-04	6.55e-01
Ubiquitin-dependent degradation of Cyclin D	44	3.52e-03	1.42e-02	0.28800	0.282000	5.77e-02	1.24e-03	5.08e-01
Antigen processing: Ubiquitination & Proteasome degradation	236	3.61e-03	1.45e-02	0.12200	0.096300	7.55e-02	1.14e-02	4.72e-02
Transport of the SLBP Dependant Mature mRNA	34	3.84e-03	1.53e-02	0.34300	-0.280000	1.98e-01	4.72e-03	4.56e-02
Metabolism of polyamines	48	3.85e-03	1.53e-02	0.27200	0.265000	6.44e-02	1.53e-03	4.41e-01
Growth hormone receptor signaling	17	4.04e-03	1.60e-02	0.45200	0.428000	1.46e-01	2.26e-03	2.96e-01
Golgi Cisternae Pericentriolar Stack Reorganization	14	4.06e-03	1.60e-02	0.49900	0.477000	1.48e-01	2.01e-03	3.39e-01
EGFR downregulation	20	4.06e-03	1.60e-02	0.42600	0.426000	1.38e-02	9.78e-04	9.15e-01
Iron uptake and transport	38	4.16e-03	1.64e-02	0.31100	0.311000	-1.58e-02	9.35e-04	8.67e-01
Base Excision Repair	36	4.23e-03	1.66e-02	0.31700	-0.317000	-1.94e-03	9.91e-04	9.84e-01
VEGFA-VEGFR2 Pathway	71	4.47e-03	1.74e-02	0.22100	0.212000	6.08e-02	2.04e-03	3.77e-01
p75 NTR receptor-mediated signalling	60	4.69e-03	1.82e-02	0.24200	0.240000	2.95e-02	1.34e-03	6.93e-01
ISG15 antiviral mechanism	70	4.73e-03	1.83e-02	0.23600	-0.179000	1.53e-01	9.59e-03	2.73e-02
Autodegradation of Cdh1 by Cdh1:APC/C	56	4.83e-03	1.87e-02	0.24500	0.228000	8.87e-02	3.15e-03	2.52e-01
TNFR2 non-canonical NF-kB pathway	67	4.89e-03	1.88e-02	0.22300	0.202000	9.40e-02	4.25e-03	1.84e-01
Activation of NF-kappaB in B cells	57	4.93e-03	1.89e-02	0.24500	0.240000	4.81e-02	1.72e-03	5.31e-01
Collagen degradation	14	5.10e-03	1.94e-02	0.48100	0.381000	2.94e-01	1.37e-02	5.69e-02
Metabolism of carbohydrates	177	5.12e-03	1.94e-02	0.14400	0.142000	-2.15e-02	1.19e-03	6.24e-01
SUMOylation of SUMOylation proteins	32	5.12e-03	1.94e-02	0.34500	-0.272000	2.12e-01	7.69e-03	3.85e-02
Plasma lipoprotein clearance	19	5.21e-03	1.97e-02	0.43700	0.425000	-1.00e-01	1.35e-03	4.49e-01
Opioid Signalling	55	5.37e-03	2.03e-02	0.24800	0.243000	4.69e-02	1.83e-03	5.48e-01
Transmission across Chemical Synapses	95	5.66e-03	2.13e-02	0.19900	0.150000	-1.32e-01	1.20e-02	2.70e-02
Autodegradation of the E3 ubiquitin ligase COP1	43	5.78e-03	2.17e-02	0.27600	0.264000	7.97e-02	2.74e-03	3.67e-01
Telomere C-strand (Lagging Strand) Synthesis	29	5.93e-03	2.21e-02	0.34600	-0.344000	4.13e-02	1.37e-03	7.01e-01
Regulation of lipid metabolism by PPARalpha	81	6.05e-03	2.25e-02	0.20000	0.187000	7.13e-02	3.77e-03	2.69e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	64	6.07e-03	2.25e-02	0.22500	0.215000	6.63e-02	2.93e-03	3.60e-01
Regulation of RUNX3 expression and activity	49	6.20e-03	2.29e-02	0.25800	0.249000	6.48e-02	2.57e-03	4.34e-01
Potential therapeutics for SARS	26	6.22e-03	2.29e-02	0.34700	0.275000	2.11e-01	1.53e-02	6.29e-02
Formation of the ternary complex, and subsequently, the 43S complex	40	6.26e-03	2.30e-02	0.29800	-0.099700	2.81e-01	2.76e-01	2.12e-03
Prolonged ERK activation events	13	6.30e-03	2.30e-02	0.49000	0.413000	2.64e-01	9.98e-03	9.90e-02
Late Phase of HIV Life Cycle	115	6.31e-03	2.30e-02	0.17200	0.001110	1.72e-01	9.84e-01	1.52e-03
Spry regulation of FGF signaling	15	6.34e-03	2.30e-02	0.46000	0.428000	1.70e-01	4.16e-03	2.55e-01
Extracellular matrix organization	91	6.35e-03	2.30e-02	0.19600	0.191000	-4.52e-02	1.67e-03	4.57e-01
SUMOylation of DNA damage response and repair proteins	67	6.51e-03	2.35e-02	0.23300	-0.197000	1.24e-01	5.35e-03	8.08e-02
HCMV Early Events	50	6.62e-03	2.38e-02	0.27000	-0.201000	1.80e-01	1.40e-02	2.82e-02
APC/C:Cdc20 mediated degradation of Securin	58	6.71e-03	2.40e-02	0.23400	0.221000	7.56e-02	3.60e-03	3.20e-01
Response of Mtb to phagocytosis	20	6.71e-03	2.40e-02	0.39700	0.374000	1.34e-01	3.83e-03	2.99e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	23	6.83e-03	2.43e-02	0.36500	0.225000	2.87e-01	6.17e-02	1.72e-02
Signaling by VEGF	73	6.83e-03	2.43e-02	0.20900	0.199000	6.19e-02	3.31e-03	3.62e-01
Transcriptional regulation by small RNAs	43	7.11e-03	2.51e-02	0.28900	-0.201000	2.08e-01	2.29e-02	1.86e-02
Transport of Mature mRNA Derived from an Intronless Transcript	40	7.11e-03	2.51e-02	0.29600	-0.271000	1.18e-01	3.02e-03	1.97e-01
Protein ubiquitination	59	7.15e-03	2.52e-02	0.23200	0.224000	5.81e-02	2.95e-03	4.41e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	56	7.27e-03	2.55e-02	0.23900	0.235000	4.21e-02	2.41e-03	5.87e-01
SUMOylation of DNA replication proteins	43	7.31e-03	2.56e-02	0.28800	-0.194000	2.13e-01	2.78e-02	1.60e-02
Extension of Telomeres	44	7.34e-03	2.56e-02	0.27800	-0.271000	6.17e-02	1.92e-03	4.80e-01
Plasma lipoprotein assembly, remodeling, and clearance	32	7.49e-03	2.60e-02	0.32100	0.320000	-2.98e-02	1.76e-03	7.70e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	10	7.57e-03	2.62e-02	0.59400	0.405000	-4.34e-01	2.65e-02	1.75e-02
Constitutive Signaling by AKT1 E17K in Cancer	23	7.57e-03	2.62e-02	0.36300	0.166000	3.23e-01	1.69e-01	7.32e-03
Postmitotic nuclear pore complex (NPC) reformation	26	7.63e-03	2.63e-02	0.36600	-0.320000	1.78e-01	4.82e-03	1.16e-01
Nuclear Pore Complex (NPC) Disassembly	34	7.69e-03	2.64e-02	0.32200	-0.223000	2.32e-01	2.45e-02	1.93e-02
Phosphorylation of CD3 and TCR zeta chains	10	7.73e-03	2.65e-02	0.58400	-0.207000	5.46e-01	2.56e-01	2.80e-03
Neuronal System	128	7.87e-03	2.68e-02	0.16600	0.121000	-1.14e-01	1.84e-02	2.63e-02
SUMOylation of RNA binding proteins	42	7.88e-03	2.68e-02	0.28900	-0.217000	1.91e-01	1.53e-02	3.20e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	45	7.91e-03	2.69e-02	0.27100	0.268000	-4.07e-02	1.91e-03	6.37e-01
Homology Directed Repair	88	8.00e-03	2.71e-02	0.19400	-0.191000	3.61e-02	2.00e-03	5.60e-01
SCF-beta-TrCP mediated degradation of Emi1	47	8.19e-03	2.76e-02	0.25600	0.247000	6.60e-02	3.45e-03	4.34e-01
WNT5A-dependent internalization of FZD4	10	8.21e-03	2.76e-02	0.56500	0.565000	-8.45e-03	1.99e-03	9.63e-01
HDR through Single Strand Annealing (SSA)	34	8.32e-03	2.78e-02	0.31000	-0.306000	5.31e-02	2.06e-03	5.92e-01
RHO GTPases activate PAKs	13	8.33e-03	2.78e-02	0.49200	0.491000	2.84e-02	2.18e-03	8.59e-01
RAF activation	28	8.66e-03	2.88e-02	0.32800	0.313000	9.71e-02	4.14e-03	3.74e-01
Transcriptional regulation by RUNX3	75	8.67e-03	2.88e-02	0.20100	0.192000	6.01e-02	4.20e-03	3.69e-01
Infection with Mycobacterium tuberculosis	22	8.93e-03	2.95e-02	0.37100	0.363000	7.57e-02	3.19e-03	5.39e-01
Signaling by Hedgehog	97	8.94e-03	2.95e-02	0.18200	0.181000	-2.54e-02	2.17e-03	6.66e-01
NOTCH1 Intracellular Domain Regulates Transcription	37	8.95e-03	2.95e-02	0.30000	0.277000	-1.14e-01	3.54e-03	2.30e-01
Neurotransmitter release cycle	19	9.07e-03	2.98e-02	0.40600	0.012500	-4.06e-01	9.25e-01	2.19e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript	54	9.51e-03	3.11e-02	0.25000	-0.167000	1.86e-01	3.40e-02	1.82e-02
CDT1 association with the CDC6:ORC:origin complex	50	9.57e-03	3.11e-02	0.24000	0.209000	1.18e-01	1.06e-02	1.49e-01
CDK-mediated phosphorylation and removal of Cdc6	62	9.58e-03	3.11e-02	0.21700	0.195000	9.43e-02	8.03e-03	2.00e-01
Notch-HLH transcription pathway	21	9.59e-03	3.11e-02	0.39400	0.371000	-1.31e-01	3.26e-03	2.98e-01
Interleukin-4 and Interleukin-13 signaling	48	9.79e-03	3.17e-02	0.24700	0.232000	8.37e-02	5.45e-03	3.16e-01
Assembly of the pre-replicative complex	59	1.00e-02	3.23e-02	0.21900	0.144000	1.66e-01	5.68e-02	2.81e-02
G-protein beta:gamma signalling	20	1.01e-02	3.26e-02	0.37700	0.327000	1.88e-01	1.14e-02	1.47e-01
Regulation of expression of SLITs and ROBOs	122	1.01e-02	3.26e-02	0.16000	-0.009850	1.59e-01	8.51e-01	2.45e-03
ESR-mediated signaling	112	1.03e-02	3.28e-02	0.15900	0.104000	1.21e-01	5.88e-02	2.80e-02
Amyloid fiber formation	24	1.03e-02	3.28e-02	0.35900	0.357000	-4.33e-02	2.50e-03	7.14e-01
Transport of Mature mRNAs Derived from Intronless Transcripts	41	1.04e-02	3.30e-02	0.28200	-0.253000	1.25e-01	5.19e-03	1.68e-01
Regulation of RAS by GAPs	56	1.06e-02	3.35e-02	0.22800	0.219000	6.21e-02	4.63e-03	4.22e-01
Cell Cycle, Mitotic	418	1.07e-02	3.39e-02	0.08900	-0.028600	8.43e-02	3.22e-01	3.54e-03
FCERI mediated MAPK activation	25	1.09e-02	3.44e-02	0.34800	0.347000	-2.25e-02	2.65e-03	8.45e-01
Energy dependent regulation of mTOR by LKB1-AMPK	26	1.10e-02	3.46e-02	0.34300	0.340000	-4.65e-02	2.71e-03	6.82e-01
mTORC1-mediated signalling	21	1.11e-02	3.47e-02	0.37100	0.362000	8.16e-02	4.14e-03	5.18e-01
G alpha (i) signalling events	112	1.13e-02	3.54e-02	0.16400	0.164000	-8.66e-03	2.77e-03	8.75e-01
RHO GTPases activate CIT	14	1.14e-02	3.55e-02	0.44500	0.393000	2.09e-01	1.09e-02	1.76e-01
SUMOylation of ubiquitinylation proteins	37	1.16e-02	3.59e-02	0.29600	-0.210000	2.08e-01	2.70e-02	2.90e-02
Degradation of AXIN	47	1.16e-02	3.59e-02	0.24700	0.242000	5.17e-02	4.22e-03	5.40e-01
Stabilization of p53	48	1.16e-02	3.59e-02	0.24300	0.231000	7.40e-02	5.64e-03	3.76e-01
Cell Cycle Checkpoints	222	1.18e-02	3.64e-02	0.12000	-0.040400	1.13e-01	3.03e-01	4.07e-03
tRNA modification in the nucleus and cytosol	34	1.20e-02	3.68e-02	0.29500	-0.295000	1.25e-02	2.95e-03	8.99e-01
Sphingolipid metabolism	50	1.21e-02	3.72e-02	0.24800	0.239000	-6.47e-02	3.51e-03	4.29e-01
HIV Life Cycle	127	1.27e-02	3.88e-02	0.15300	-0.008500	1.52e-01	8.69e-01	3.13e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	62	1.28e-02	3.91e-02	0.21000	0.194000	8.10e-02	8.32e-03	2.71e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	48	1.29e-02	3.92e-02	0.24700	-0.016600	2.46e-01	8.42e-01	3.18e-03
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	63	1.29e-02	3.92e-02	0.20800	0.192000	8.02e-02	8.38e-03	2.72e-01
TBC/RABGAPs	38	1.32e-02	4.00e-02	0.27700	0.276000	-2.70e-02	3.27e-03	7.74e-01
Signaling by NOTCH2	18	1.32e-02	4.00e-02	0.40600	0.398000	-7.80e-02	3.48e-03	5.67e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	65	1.34e-02	4.04e-02	0.20400	0.187000	8.21e-02	9.29e-03	2.53e-01
Signaling by Nuclear Receptors	147	1.38e-02	4.15e-02	0.13500	0.101000	8.90e-02	3.55e-02	6.37e-02
Regulation of TP53 Activity	131	1.41e-02	4.22e-02	0.15400	-0.115000	1.02e-01	2.31e-02	4.38e-02
Listeria monocytogenes entry into host cells	14	1.42e-02	4.23e-02	0.43200	0.299000	3.11e-01	5.28e-02	4.40e-02
Ribosomal scanning and start codon recognition	47	1.45e-02	4.32e-02	0.24800	-0.035600	2.45e-01	6.73e-01	3.68e-03
Downstream signaling events of B Cell Receptor (BCR)	70	1.46e-02	4.34e-02	0.19500	0.176000	8.37e-02	1.12e-02	2.27e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	66	1.47e-02	4.34e-02	0.20100	0.188000	7.11e-02	8.35e-03	3.19e-01
Beta-catenin phosphorylation cascade	15	1.50e-02	4.41e-02	0.41800	0.380000	1.74e-01	1.09e-02	2.42e-01
COPI-dependent Golgi-to-ER retrograde traffic	64	1.50e-02	4.41e-02	0.20600	0.202000	3.99e-02	5.26e-03	5.81e-01
MAPK targets/ Nuclear events mediated by MAP kinases	24	1.51e-02	4.43e-02	0.33000	0.296000	1.45e-01	1.20e-02	2.19e-01
Class A/1 (Rhodopsin-like receptors)	40	1.55e-02	4.54e-02	0.27500	0.205000	-1.83e-01	2.51e-02	4.56e-02
Transcriptional regulation by RUNX2	83	1.55e-02	4.54e-02	0.18500	0.184000	-2.19e-02	3.92e-03	7.31e-01
Diseases of carbohydrate metabolism	22	1.56e-02	4.56e-02	0.36400	0.341000	-1.28e-01	5.66e-03	2.98e-01
Lagging Strand Synthesis	17	1.59e-02	4.62e-02	0.41000	-0.399000	9.15e-02	4.40e-03	5.14e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	19	1.59e-02	4.62e-02	0.37700	0.374000	4.38e-02	4.78e-03	7.41e-01
G beta:gamma signalling through PI3Kgamma	16	1.61e-02	4.64e-02	0.39900	0.224000	3.30e-01	1.22e-01	2.24e-02
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	28	1.62e-02	4.64e-02	0.30100	0.202000	2.22e-01	6.41e-02	4.19e-02
Negative regulation of FGFR1 signaling	17	1.62e-02	4.64e-02	0.38700	0.332000	1.99e-01	1.79e-02	1.55e-01
Negative regulation of FGFR2 signaling	17	1.62e-02	4.64e-02	0.38700	0.332000	1.99e-01	1.79e-02	1.55e-01
Negative regulation of FGFR3 signaling	17	1.62e-02	4.64e-02	0.38700	0.332000	1.99e-01	1.79e-02	1.55e-01
Negative regulation of FGFR4 signaling	17	1.62e-02	4.64e-02	0.38700	0.332000	1.99e-01	1.79e-02	1.55e-01
XBP1(S) activates chaperone genes	36	1.63e-02	4.64e-02	0.26700	0.239000	1.20e-01	1.34e-02	2.13e-01
Signaling by Leptin	10	1.65e-02	4.70e-02	0.53600	0.503000	-1.86e-01	5.90e-03	3.10e-01
Asymmetric localization of PCP proteins	51	1.66e-02	4.70e-02	0.22900	0.228000	2.50e-02	4.93e-03	7.57e-01
Glycogen metabolism	17	1.68e-02	4.73e-02	0.41200	0.376000	-1.68e-01	7.25e-03	2.29e-01
Translation initiation complex formation	47	1.68e-02	4.73e-02	0.24300	-0.029300	2.41e-01	7.29e-01	4.27e-03
Fatty acid metabolism	102	1.76e-02	4.96e-02	0.17000	0.127000	-1.13e-01	2.77e-02	4.85e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus	15	1.79e-02	5.00e-02	0.42200	0.422000	-5.58e-03	4.65e-03	9.70e-01
Protein methylation	12	1.79e-02	5.00e-02	0.46100	0.129000	4.43e-01	4.40e-01	7.90e-03
Signaling by EGFR	36	1.79e-02	5.00e-02	0.27200	0.272000	2.35e-03	4.73e-03	9.81e-01
Viral Messenger RNA Synthesis	40	1.84e-02	5.13e-02	0.26900	-0.203000	1.76e-01	2.63e-02	5.43e-02
M Phase	292	1.84e-02	5.13e-02	0.09400	0.035800	8.69e-02	2.97e-01	1.14e-02
RNA Polymerase III Transcription Initiation From Type 1 Promoter	25	1.86e-02	5.16e-02	0.34000	-0.246000	2.34e-01	3.34e-02	4.29e-02
IRE1alpha activates chaperones	37	1.91e-02	5.29e-02	0.25700	0.214000	1.42e-01	2.43e-02	1.36e-01
Prefoldin mediated transfer of substrate to CCT/TriC	17	1.92e-02	5.31e-02	0.38600	0.377000	8.27e-02	7.14e-03	5.55e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	27	2.00e-02	5.51e-02	0.30500	0.297000	6.89e-02	7.66e-03	5.36e-01
Metabolism of steroids	81	2.03e-02	5.58e-02	0.18300	0.178000	-4.13e-02	5.77e-03	5.22e-01
Telomere Maintenance	55	2.04e-02	5.58e-02	0.22200	-0.212000	6.70e-02	6.58e-03	3.91e-01
Recycling pathway of L1	16	2.06e-02	5.62e-02	0.39900	0.399000	2.39e-02	5.80e-03	8.69e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	24	2.10e-02	5.71e-02	0.34100	-0.236000	2.47e-01	4.54e-02	3.67e-02
Frs2-mediated activation	11	2.12e-02	5.76e-02	0.46300	0.339000	3.15e-01	5.13e-02	7.05e-02
PCNA-Dependent Long Patch Base Excision Repair	18	2.13e-02	5.78e-02	0.37600	-0.376000	-1.28e-03	5.71e-03	9.93e-01
Mitochondrial tRNA aminoacylation	18	2.16e-02	5.86e-02	0.38400	-0.370000	1.04e-01	6.63e-03	4.44e-01
Regulation of IFNG signaling	13	2.21e-02	5.95e-02	0.43400	0.426000	8.60e-02	7.92e-03	5.92e-01
Diseases associated with the TLR signaling cascade	15	2.22e-02	5.96e-02	0.40500	0.401000	6.10e-02	7.23e-03	6.83e-01
Diseases of Immune System	15	2.22e-02	5.96e-02	0.40500	0.401000	6.10e-02	7.23e-03	6.83e-01
Epigenetic regulation of gene expression	75	2.24e-02	5.99e-02	0.19200	-0.113000	1.55e-01	9.14e-02	2.08e-02
Extra-nuclear estrogen signaling	48	2.29e-02	6.11e-02	0.22000	0.148000	1.63e-01	7.64e-02	5.15e-02
Signaling by the B Cell Receptor (BCR)	91	2.30e-02	6.12e-02	0.16400	0.159000	3.69e-02	8.80e-03	5.44e-01
Nucleobase catabolism	22	2.30e-02	6.12e-02	0.34700	0.325000	-1.22e-01	8.39e-03	3.23e-01
Integrin signaling	17	2.32e-02	6.15e-02	0.37300	0.350000	1.28e-01	1.24e-02	3.60e-01
Platelet Aggregation (Plug Formation)	17	2.32e-02	6.15e-02	0.37300	0.350000	1.28e-01	1.24e-02	3.60e-01
RHO GTPases Activate NADPH Oxidases	14	2.33e-02	6.16e-02	0.42100	0.421000	1.15e-02	6.43e-03	9.41e-01
Formation of tubulin folding intermediates by CCT/TriC	14	2.34e-02	6.18e-02	0.40900	0.375000	1.64e-01	1.51e-02	2.90e-01
Transport of Mature Transcript to Cytoplasm	63	2.36e-02	6.20e-02	0.20800	-0.141000	1.52e-01	5.26e-02	3.68e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	45	2.38e-02	6.25e-02	0.23000	0.219000	6.78e-02	1.10e-02	4.32e-01
Other semaphorin interactions	10	2.43e-02	6.36e-02	0.51700	0.420000	-3.01e-01	2.14e-02	9.94e-02
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	21	2.50e-02	6.53e-02	0.32900	0.275000	1.81e-01	2.95e-02	1.51e-01
ERK/MAPK targets	17	2.55e-02	6.64e-02	0.37900	0.379000	-7.53e-03	6.86e-03	9.57e-01
Signaling by NOTCH3	30	2.56e-02	6.66e-02	0.28400	0.283000	1.28e-02	7.26e-03	9.04e-01
LDL clearance	13	2.62e-02	6.80e-02	0.43500	0.432000	-5.17e-02	7.00e-03	7.47e-01
Platelet homeostasis	48	2.65e-02	6.87e-02	0.22400	0.224000	9.00e-06	7.26e-03	1.00e+00
Signal amplification	19	2.67e-02	6.90e-02	0.35900	0.356000	-4.48e-02	7.17e-03	7.35e-01
Intraflagellar transport	35	2.71e-02	6.97e-02	0.25700	-0.248000	-6.42e-02	1.10e-02	5.11e-01
Platelet sensitization by LDL	13	2.72e-02	7.00e-02	0.42700	0.427000	1.73e-02	7.72e-03	9.14e-01
Selective autophagy	48	2.75e-02	7.04e-02	0.22300	0.223000	2.38e-03	7.59e-03	9.77e-01
Interleukin-10 signaling	13	2.78e-02	7.11e-02	0.44500	0.268000	-3.56e-01	9.48e-02	2.63e-02
GPCR ligand binding	67	2.79e-02	7.11e-02	0.19700	0.137000	-1.42e-01	5.36e-02	4.47e-02
UCH proteinases	74	2.93e-02	7.45e-02	0.18000	0.179000	-2.45e-02	7.96e-03	7.17e-01
Thrombin signalling through proteinase activated receptors (PARs)	19	3.11e-02	7.89e-02	0.34800	0.348000	3.74e-03	8.72e-03	9.78e-01
SUMOylation of immune response proteins	10	3.11e-02	7.89e-02	0.46100	0.307000	3.44e-01	9.30e-02	5.98e-02
Oxidative Stress Induced Senescence	54	3.16e-02	7.98e-02	0.19900	0.170000	1.04e-01	3.14e-02	1.85e-01
Complex I biogenesis	41	3.17e-02	8.00e-02	0.24100	0.236000	-4.91e-02	9.15e-03	5.87e-01
Mitotic Anaphase	193	3.18e-02	8.02e-02	0.10600	0.072800	7.65e-02	8.29e-02	6.86e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	16	3.21e-02	8.07e-02	0.36300	0.287000	2.22e-01	4.67e-02	1.24e-01
Regulation of RUNX2 expression and activity	57	3.27e-02	8.19e-02	0.19500	0.181000	7.09e-02	1.82e-02	3.55e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	25	3.31e-02	8.26e-02	0.29700	0.292000	5.13e-02	1.15e-02	6.57e-01
DARPP-32 events	20	3.31e-02	8.26e-02	0.33400	0.333000	2.91e-02	1.01e-02	8.22e-01
Deubiquitination	192	3.32e-02	8.26e-02	0.10900	0.109000	2.20e-03	9.43e-03	9.58e-01
Neurotransmitter receptors and postsynaptic signal transmission	73	3.34e-02	8.30e-02	0.18100	0.172000	-5.66e-02	1.14e-02	4.04e-01
Signaling by ROBO receptors	153	3.35e-02	8.30e-02	0.11900	0.037300	1.13e-01	4.29e-01	1.60e-02
Stimuli-sensing channels	39	3.37e-02	8.32e-02	0.24800	0.225000	-1.06e-01	1.52e-02	2.55e-01
Chaperonin-mediated protein folding	57	3.40e-02	8.39e-02	0.19600	0.194000	3.08e-02	1.15e-02	6.89e-01
Cellular Senescence	105	3.52e-02	8.64e-02	0.14000	0.101000	9.76e-02	7.49e-02	8.49e-02
E3 ubiquitin ligases ubiquitinate target proteins	41	3.53e-02	8.64e-02	0.23100	0.230000	2.01e-02	1.08e-02	8.24e-01
Glucagon signaling in metabolic regulation	17	3.53e-02	8.64e-02	0.36000	0.359000	1.94e-02	1.04e-02	8.90e-01
EPH-ephrin mediated repulsion of cells	26	3.53e-02	8.64e-02	0.30200	0.276000	-1.22e-01	1.50e-02	2.83e-01
Mitotic Metaphase and Anaphase	194	3.56e-02	8.69e-02	0.10400	0.067800	7.84e-02	1.06e-01	6.12e-02
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	82	3.57e-02	8.70e-02	0.16700	-0.165000	2.70e-02	1.01e-02	6.73e-01
tRNA Aminoacylation	23	3.62e-02	8.79e-02	0.31700	-0.303000	9.44e-02	1.21e-02	4.33e-01
RNA Polymerase I Transcription Initiation	41	3.63e-02	8.79e-02	0.24000	-0.217000	1.03e-01	1.65e-02	2.55e-01
SUMOylation of chromatin organization proteins	49	3.64e-02	8.80e-02	0.22100	-0.175000	1.35e-01	3.41e-02	1.03e-01
Muscle contraction	65	3.67e-02	8.87e-02	0.19200	0.126000	-1.45e-01	8.01e-02	4.33e-02
Assembly Of The HIV Virion	14	3.75e-02	9.03e-02	0.38300	0.352000	1.50e-01	2.25e-02	3.31e-01
SARS-CoV-1 Infection	43	3.76e-02	9.04e-02	0.21700	0.166000	1.39e-01	5.96e-02	1.16e-01
Signaling by TGFB family members	73	3.81e-02	9.14e-02	0.17900	0.162000	-7.58e-02	1.71e-02	2.64e-01
Nuclear Envelope Breakdown	49	3.84e-02	9.19e-02	0.21900	-0.113000	1.87e-01	1.72e-01	2.37e-02
Death Receptor Signalling	96	3.85e-02	9.19e-02	0.15100	0.151000	-1.10e-03	1.09e-02	9.85e-01
Rap1 signalling	10	3.94e-02	9.38e-02	0.44900	0.188000	4.08e-01	3.02e-01	2.56e-02
Regulation of APC/C activators between G1/S and early anaphase	70	3.96e-02	9.41e-02	0.17000	0.148000	8.34e-02	3.31e-02	2.29e-01
Diseases associated with O-glycosylation of proteins	21	3.98e-02	9.45e-02	0.33000	-0.297000	1.44e-01	1.85e-02	2.54e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	10	4.04e-02	9.57e-02	0.45500	0.448000	7.97e-02	1.43e-02	6.63e-01
G1/S DNA Damage Checkpoints	57	4.07e-02	9.62e-02	0.18800	0.170000	7.96e-02	2.68e-02	3.00e-01
Processing of DNA double-strand break ends	54	4.15e-02	9.78e-02	0.20600	-0.169000	1.18e-01	3.20e-02	1.33e-01
RNA Polymerase III Transcription Initiation	33	4.21e-02	9.91e-02	0.26300	-0.166000	2.04e-01	9.87e-02	4.24e-02
Glycosaminoglycan metabolism	61	4.31e-02	1.01e-01	0.19000	0.179000	-6.50e-02	1.58e-02	3.81e-01
Activation of BAD and translocation to mitochondria	14	4.34e-02	1.02e-01	0.37500	0.351000	1.33e-01	2.30e-02	3.90e-01
Hedgehog 'off' state	75	4.43e-02	1.03e-01	0.16500	0.164000	1.61e-02	1.40e-02	8.10e-01
activated TAK1 mediates p38 MAPK activation	13	4.46e-02	1.04e-01	0.39000	0.375000	1.08e-01	1.94e-02	5.02e-01
p53-Dependent G1 DNA Damage Response	55	4.50e-02	1.05e-01	0.18800	0.173000	7.33e-02	2.64e-02	3.48e-01
p53-Dependent G1/S DNA damage checkpoint	55	4.50e-02	1.05e-01	0.18800	0.173000	7.33e-02	2.64e-02	3.48e-01
PLC beta mediated events	30	4.62e-02	1.07e-01	0.26600	0.258000	-6.64e-02	1.46e-02	5.29e-01
Inositol phosphate metabolism	29	4.70e-02	1.09e-01	0.27100	0.259000	-7.95e-02	1.58e-02	4.59e-01
Effects of PIP2 hydrolysis	19	4.71e-02	1.09e-01	0.33900	-0.293000	1.71e-01	2.71e-02	1.98e-01
Signaling by Non-Receptor Tyrosine Kinases	33	4.77e-02	1.10e-01	0.24000	0.218000	1.01e-01	3.06e-02	3.15e-01
Signaling by PTK6	33	4.77e-02	1.10e-01	0.24000	0.218000	1.01e-01	3.06e-02	3.15e-01
Peroxisomal protein import	48	4.80e-02	1.10e-01	0.20200	0.198000	3.82e-02	1.75e-02	6.47e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	14	4.90e-02	1.12e-01	0.38600	0.372000	-1.05e-01	1.60e-02	4.98e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	32	4.94e-02	1.13e-01	0.25100	0.250000	-8.18e-03	1.43e-02	9.36e-01
ADP signalling through P2Y purinoceptor 12	12	4.95e-02	1.13e-01	0.39200	0.276000	2.78e-01	9.78e-02	9.59e-02
Cell death signalling via NRAGE, NRIF and NADE	46	4.97e-02	1.13e-01	0.21200	0.207000	-4.61e-02	1.53e-02	5.89e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	32	5.00e-02	1.14e-01	0.26000	-0.203000	1.63e-01	4.70e-02	1.12e-01
Separation of Sister Chromatids	145	5.01e-02	1.14e-01	0.11400	0.054600	1.00e-01	2.59e-01	3.85e-02
Costimulation by the CD28 family	45	5.05e-02	1.14e-01	0.21300	-0.037800	2.10e-01	6.62e-01	1.50e-02
Glycogen synthesis	11	5.09e-02	1.15e-01	0.43000	0.424000	-7.17e-02	1.50e-02	6.81e-01
Apoptotic cleavage of cellular proteins	25	5.16e-02	1.16e-01	0.27000	0.198000	1.83e-01	8.66e-02	1.14e-01
Calnexin/calreticulin cycle	23	5.17e-02	1.16e-01	0.29200	0.291000	1.07e-02	1.56e-02	9.29e-01
G-protein activation	13	5.24e-02	1.18e-01	0.37300	0.263000	2.64e-01	1.00e-01	9.98e-02
Synthesis of PC	19	5.27e-02	1.18e-01	0.31000	0.277000	1.40e-01	3.66e-02	2.92e-01
Vasopressin regulates renal water homeostasis via Aquaporins	21	5.28e-02	1.18e-01	0.29500	0.260000	1.39e-01	3.90e-02	2.72e-01
Gap junction trafficking and regulation	10	5.29e-02	1.18e-01	0.44700	0.442000	-6.91e-02	1.56e-02	7.05e-01
Uptake and actions of bacterial toxins	19	5.31e-02	1.18e-01	0.32900	0.310000	-1.11e-01	1.96e-02	4.01e-01
Nucleobase biosynthesis	10	5.31e-02	1.18e-01	0.45800	-0.237000	3.92e-01	1.94e-01	3.19e-02
Deposition of new CENPA-containing nucleosomes at the centromere	20	5.35e-02	1.18e-01	0.31300	-0.312000	1.09e-02	1.56e-02	9.33e-01
Nucleosome assembly	20	5.35e-02	1.18e-01	0.31300	-0.312000	1.09e-02	1.56e-02	9.33e-01
Suppression of phagosomal maturation	12	5.36e-02	1.18e-01	0.39100	0.363000	1.46e-01	2.96e-02	3.82e-01
Interleukin-6 family signaling	12	5.39e-02	1.19e-01	0.39500	0.385000	8.71e-02	2.10e-02	6.01e-01
Transcription of the HIV genome	55	5.43e-02	1.20e-01	0.18700	0.014900	1.86e-01	8.48e-01	1.72e-02
APC/C-mediated degradation of cell cycle proteins	77	5.52e-02	1.21e-01	0.15300	0.135000	7.23e-02	4.08e-02	2.74e-01
Regulation of mitotic cell cycle	77	5.52e-02	1.21e-01	0.15300	0.135000	7.23e-02	4.08e-02	2.74e-01
Prostacyclin signalling through prostacyclin receptor	11	5.61e-02	1.23e-01	0.40100	0.226000	3.32e-01	1.95e-01	5.67e-02
EML4 and NUDC in mitotic spindle formation	85	5.62e-02	1.23e-01	0.15400	-0.038900	1.49e-01	5.36e-01	1.82e-02
Negative regulation of the PI3K/AKT network	51	5.76e-02	1.26e-01	0.18800	0.177000	6.38e-02	2.91e-02	4.31e-01
Transcriptional regulation of granulopoiesis	24	5.85e-02	1.27e-01	0.29200	0.244000	-1.60e-01	3.91e-02	1.74e-01
Triglyceride catabolism	11	5.93e-02	1.29e-01	0.42400	0.400000	-1.41e-01	2.18e-02	4.17e-01
Generation of second messenger molecules	16	6.06e-02	1.31e-01	0.35400	-0.308000	1.74e-01	3.30e-02	2.28e-01
S Phase	138	6.17e-02	1.33e-01	0.12100	-0.066300	1.01e-01	1.80e-01	4.06e-02
Unfolded Protein Response (UPR)	70	6.23e-02	1.34e-01	0.15700	0.130000	8.70e-02	5.98e-02	2.09e-01
Myogenesis	13	6.25e-02	1.35e-01	0.39300	0.286000	-2.68e-01	7.38e-02	9.39e-02
Transcriptional regulation of white adipocyte differentiation	55	6.32e-02	1.36e-01	0.17800	0.169000	5.76e-02	3.06e-02	4.60e-01
Intrinsic Pathway for Apoptosis	45	6.34e-02	1.36e-01	0.19600	0.182000	7.45e-02	3.53e-02	3.88e-01
GPVI-mediated activation cascade	24	6.39e-02	1.37e-01	0.26500	0.195000	1.80e-01	9.84e-02	1.28e-01
G alpha (z) signalling events	24	6.41e-02	1.37e-01	0.26500	0.215000	1.56e-01	6.84e-02	1.88e-01
Regulation of TP53 Expression and Degradation	33	6.47e-02	1.38e-01	0.23900	-0.046500	2.34e-01	6.45e-01	2.01e-02
ERKs are inactivated	12	6.50e-02	1.38e-01	0.38300	0.376000	7.26e-02	2.42e-02	6.64e-01
Orc1 removal from chromatin	61	6.64e-02	1.41e-01	0.16600	0.087000	1.41e-01	2.41e-01	5.64e-02
Cell recruitment (pro-inflammatory response)	14	6.65e-02	1.41e-01	0.35500	0.352000	4.49e-02	2.27e-02	7.71e-01
Purinergic signaling in leishmaniasis infection	14	6.65e-02	1.41e-01	0.35500	0.352000	4.49e-02	2.27e-02	7.71e-01
Apoptotic execution phase	33	6.65e-02	1.41e-01	0.22900	0.219000	6.40e-02	2.93e-02	5.25e-01
Maturation of nucleoprotein	10	6.75e-02	1.42e-01	0.43700	-0.181000	3.97e-01	3.22e-01	2.97e-02
Defects in vitamin and cofactor metabolism	16	6.83e-02	1.44e-01	0.34200	-0.326000	1.01e-01	2.39e-02	4.83e-01
Interleukin-15 signaling	12	6.86e-02	1.44e-01	0.40100	0.249000	-3.15e-01	1.36e-01	5.91e-02
SCF(Skp2)-mediated degradation of p27/p21	52	6.87e-02	1.44e-01	0.18300	0.181000	2.76e-02	2.43e-02	7.31e-01
Interleukin-6 signaling	10	6.97e-02	1.46e-01	0.40500	0.344000	2.15e-01	5.99e-02	2.39e-01
Processive synthesis on the lagging strand	13	7.02e-02	1.47e-01	0.37500	-0.365000	8.36e-02	2.26e-02	6.02e-01
Josephin domain DUBs	10	7.16e-02	1.49e-01	0.41200	0.404000	8.07e-02	2.72e-02	6.59e-01
Nucleotide salvage	18	7.18e-02	1.49e-01	0.32500	0.190000	-2.63e-01	1.63e-01	5.33e-02
Negative regulation of MAPK pathway	36	7.25e-02	1.50e-01	0.21200	0.162000	1.37e-01	9.38e-02	1.56e-01
Pre-NOTCH Expression and Processing	41	7.27e-02	1.50e-01	0.20800	0.207000	-2.73e-02	2.22e-02	7.63e-01
Regulation of PTEN gene transcription	49	7.29e-02	1.50e-01	0.18200	0.157000	9.23e-02	5.77e-02	2.64e-01
Gluconeogenesis	24	7.31e-02	1.50e-01	0.28000	0.227000	-1.64e-01	5.40e-02	1.65e-01
Anti-inflammatory response favouring Leishmania parasite infection	51	7.32e-02	1.50e-01	0.19200	0.165000	-9.78e-02	4.17e-02	2.28e-01
Leishmania parasite growth and survival	51	7.32e-02	1.50e-01	0.19200	0.165000	-9.78e-02	4.17e-02	2.28e-01
HDACs deacetylate histones	28	7.32e-02	1.50e-01	0.24100	0.216000	1.06e-01	4.76e-02	3.30e-01
DNA Replication Pre-Initiation	72	7.35e-02	1.51e-01	0.15400	0.024300	1.52e-01	7.22e-01	2.64e-02
Metabolism of steroid hormones	12	7.36e-02	1.51e-01	0.37700	0.376000	3.21e-02	2.43e-02	8.47e-01
Protein folding	63	7.43e-02	1.52e-01	0.16400	0.163000	2.17e-02	2.59e-02	7.66e-01
Collagen formation	27	7.44e-02	1.52e-01	0.26300	0.210000	-1.59e-01	5.92e-02	1.52e-01
FOXO-mediated transcription of cell death genes	14	7.46e-02	1.52e-01	0.35300	0.352000	-3.00e-02	2.27e-02	8.46e-01
Mitotic Spindle Checkpoint	96	7.52e-02	1.53e-01	0.13900	-0.055300	1.27e-01	3.51e-01	3.20e-02
G-protein mediated events	31	7.52e-02	1.53e-01	0.23900	0.235000	-4.36e-02	2.36e-02	6.75e-01
Sphingolipid de novo biosynthesis	23	7.62e-02	1.54e-01	0.28400	0.227000	-1.70e-01	5.92e-02	1.58e-01
Cilium Assembly	152	7.71e-02	1.56e-01	0.10700	-0.107000	1.15e-02	2.36e-02	8.08e-01
Glycosphingolipid metabolism	27	7.72e-02	1.56e-01	0.24900	0.248000	2.55e-02	2.61e-02	8.19e-01
Signaling by FGFR4	25	7.90e-02	1.59e-01	0.25100	0.222000	1.18e-01	5.51e-02	3.08e-01
The NLRP3 inflammasome	12	7.94e-02	1.60e-01	0.36900	0.364000	6.06e-02	2.90e-02	7.16e-01
Attenuation phase	19	7.96e-02	1.60e-01	0.29000	0.274000	9.37e-02	3.84e-02	4.80e-01
TGF-beta receptor signaling activates SMADs	32	8.02e-02	1.60e-01	0.23500	0.224000	-7.03e-02	2.86e-02	4.92e-01
Membrane binding and targetting of GAG proteins	12	8.04e-02	1.60e-01	0.36900	0.366000	4.80e-02	2.81e-02	7.74e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	12	8.04e-02	1.60e-01	0.36900	0.366000	4.80e-02	2.81e-02	7.74e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	41	8.15e-02	1.62e-01	0.20900	0.094700	-1.86e-01	2.95e-01	3.95e-02
Disorders of transmembrane transporters	105	8.19e-02	1.63e-01	0.12300	0.118000	3.64e-02	3.73e-02	5.21e-01
Signaling by FGFR3	26	8.21e-02	1.63e-01	0.24500	0.220000	1.07e-01	5.19e-02	3.47e-01
Pre-NOTCH Processing in Golgi	15	8.25e-02	1.64e-01	0.32300	0.300000	1.20e-01	4.45e-02	4.20e-01
Synthesis of DNA	103	8.26e-02	1.64e-01	0.13200	-0.058200	1.18e-01	3.09e-01	3.89e-02
Condensation of Prophase Chromosomes	11	8.41e-02	1.66e-01	0.37200	-0.292000	-2.30e-01	9.38e-02	1.87e-01
Dopamine Neurotransmitter Release Cycle	12	8.50e-02	1.68e-01	0.36000	-0.112000	-3.42e-01	5.02e-01	4.00e-02
Dual Incision in GG-NER	35	8.54e-02	1.68e-01	0.21900	-0.216000	3.38e-02	2.69e-02	7.29e-01
PRC2 methylates histones and DNA	11	8.56e-02	1.68e-01	0.39500	-0.372000	1.33e-01	3.25e-02	4.45e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	38	8.57e-02	1.68e-01	0.20200	0.187000	7.57e-02	4.65e-02	4.20e-01
DNA Replication	110	8.59e-02	1.68e-01	0.12600	-0.044600	1.18e-01	4.20e-01	3.37e-02
HIV Transcription Initiation	37	8.69e-02	1.68e-01	0.20200	0.110000	1.69e-01	2.46e-01	7.54e-02
RNA Polymerase II HIV Promoter Escape	37	8.69e-02	1.68e-01	0.20200	0.110000	1.69e-01	2.46e-01	7.54e-02
RNA Polymerase II Promoter Escape	37	8.69e-02	1.68e-01	0.20200	0.110000	1.69e-01	2.46e-01	7.54e-02
RNA Polymerase II Transcription Initiation	37	8.69e-02	1.68e-01	0.20200	0.110000	1.69e-01	2.46e-01	7.54e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance	37	8.69e-02	1.68e-01	0.20200	0.110000	1.69e-01	2.46e-01	7.54e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	37	8.69e-02	1.68e-01	0.20200	0.110000	1.69e-01	2.46e-01	7.54e-02
Switching of origins to a post-replicative state	79	8.71e-02	1.68e-01	0.14000	0.054000	1.29e-01	4.08e-01	4.85e-02
Aquaporin-mediated transport	22	8.71e-02	1.68e-01	0.26400	0.244000	1.01e-01	4.82e-02	4.11e-01
VxPx cargo-targeting to cilium	16	8.74e-02	1.68e-01	0.31200	0.304000	6.97e-02	3.51e-02	6.30e-01
Signaling by TGF-beta Receptor Complex	63	8.95e-02	1.72e-01	0.16600	0.146000	-7.82e-02	4.54e-02	2.84e-01
Host Interactions of HIV factors	106	8.95e-02	1.72e-01	0.12100	0.024900	1.19e-01	6.59e-01	3.50e-02
Meiosis	38	8.97e-02	1.72e-01	0.21100	-0.199000	7.13e-02	3.43e-02	4.48e-01
Sema4D in semaphorin signaling	15	9.02e-02	1.73e-01	0.32200	0.319000	4.53e-02	3.24e-02	7.62e-01
Mitotic Prometaphase	155	9.03e-02	1.73e-01	0.10600	-0.062400	8.63e-02	1.82e-01	6.51e-02
RHO GTPases Activate Formins	100	9.12e-02	1.74e-01	0.12800	-0.017500	1.27e-01	7.62e-01	2.89e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat	35	9.36e-02	1.78e-01	0.21400	-0.028600	2.13e-01	7.70e-01	2.97e-02
HIV Transcription Elongation	35	9.36e-02	1.78e-01	0.21400	-0.028600	2.13e-01	7.70e-01	2.97e-02
Tat-mediated elongation of the HIV-1 transcript	35	9.36e-02	1.78e-01	0.21400	-0.028600	2.13e-01	7.70e-01	2.97e-02
Regulation of TP53 Degradation	32	9.49e-02	1.80e-01	0.22400	-0.028900	2.22e-01	7.77e-01	3.02e-02
Regulation of insulin secretion	38	9.49e-02	1.80e-01	0.20500	0.204000	-2.38e-02	3.01e-02	8.00e-01
G alpha (q) signalling events	72	9.58e-02	1.81e-01	0.14200	0.119000	7.73e-02	8.07e-02	2.58e-01
Rho GTPase cycle	81	9.83e-02	1.85e-01	0.13600	0.134000	2.55e-02	3.78e-02	6.92e-01
Inflammasomes	16	9.86e-02	1.86e-01	0.30300	0.290000	8.75e-02	4.46e-02	5.45e-01
Syndecan interactions	10	1.01e-01	1.89e-01	0.37500	0.301000	2.24e-01	9.89e-02	2.20e-01
PKA activation	10	1.01e-01	1.90e-01	0.40600	0.267000	-3.07e-01	1.45e-01	9.30e-02
RNA Polymerase I Promoter Clearance	44	1.02e-01	1.91e-01	0.19300	-0.156000	1.14e-01	7.31e-02	1.92e-01
RNA Polymerase I Transcription	44	1.02e-01	1.91e-01	0.19300	-0.156000	1.14e-01	7.31e-02	1.92e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	81	1.03e-01	1.92e-01	0.14100	-0.059200	1.28e-01	3.58e-01	4.63e-02
Amplification of signal from the kinetochores	81	1.03e-01	1.92e-01	0.14100	-0.059200	1.28e-01	3.58e-01	4.63e-02
G beta:gamma signalling through CDC42	12	1.03e-01	1.92e-01	0.34100	0.272000	2.05e-01	1.03e-01	2.19e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	23	1.04e-01	1.93e-01	0.25700	-0.257000	1.65e-02	3.33e-02	8.91e-01
ADP signalling through P2Y purinoceptor 1	15	1.04e-01	1.93e-01	0.31900	0.317000	-3.19e-02	3.34e-02	8.31e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	12	1.05e-01	1.94e-01	0.35500	0.354000	-2.70e-02	3.36e-02	8.71e-01
Factors involved in megakaryocyte development and platelet production	86	1.09e-01	2.01e-01	0.13100	0.131000	1.26e-03	3.60e-02	9.84e-01
Translesion synthesis by REV1	14	1.10e-01	2.03e-01	0.33700	-0.271000	2.00e-01	7.94e-02	1.95e-01
mRNA Splicing	151	1.11e-01	2.04e-01	0.10000	-0.013100	9.93e-02	7.82e-01	3.61e-02
Sialic acid metabolism	23	1.11e-01	2.04e-01	0.25200	0.252000	3.26e-03	3.68e-02	9.78e-01
NGF-stimulated transcription	25	1.12e-01	2.06e-01	0.23400	0.210000	1.02e-01	6.93e-02	3.77e-01
Response of EIF2AK1 (HRI) to heme deficiency	13	1.13e-01	2.07e-01	0.32400	0.300000	1.23e-01	6.15e-02	4.41e-01
Organelle biogenesis and maintenance	202	1.14e-01	2.08e-01	0.08530	-0.085300	-7.22e-04	3.78e-02	9.86e-01
Sema3A PAK dependent Axon repulsion	11	1.14e-01	2.08e-01	0.36700	0.362000	-5.52e-02	3.75e-02	7.52e-01
Removal of the Flap Intermediate	12	1.15e-01	2.10e-01	0.35600	-0.331000	1.29e-01	4.69e-02	4.40e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF)	46	1.15e-01	2.10e-01	0.17900	0.177000	-2.12e-02	3.78e-02	8.04e-01
O-linked glycosylation of mucins	26	1.18e-01	2.14e-01	0.24400	0.166000	-1.79e-01	1.43e-01	1.15e-01
Cyclin E associated events during G1/S transition	72	1.19e-01	2.16e-01	0.13800	0.136000	2.64e-02	4.67e-02	6.99e-01
Gastrin-CREB signalling pathway via PKC and MAPK	12	1.20e-01	2.17e-01	0.34900	0.338000	-8.61e-02	4.24e-02	6.06e-01
Aggrephagy	18	1.21e-01	2.19e-01	0.26900	0.224000	1.49e-01	1.01e-01	2.73e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	11	1.22e-01	2.21e-01	0.37000	0.319000	-1.86e-01	6.69e-02	2.85e-01
Ub-specific processing proteases	131	1.23e-01	2.22e-01	0.09990	0.083600	5.48e-02	1.00e-01	2.81e-01
Polymerase switching on the C-strand of the telomere	22	1.25e-01	2.25e-01	0.25600	-0.248000	6.32e-02	4.46e-02	6.08e-01
Resolution of D-Loop Structures	27	1.27e-01	2.28e-01	0.22800	-0.226000	3.32e-02	4.25e-02	7.65e-01
Formation of the Early Elongation Complex	29	1.28e-01	2.30e-01	0.21400	0.041000	2.10e-01	7.02e-01	5.09e-02
Formation of the HIV-1 Early Elongation Complex	29	1.28e-01	2.30e-01	0.21400	0.041000	2.10e-01	7.02e-01	5.09e-02
Resolution of D-loop Structures through Holliday Junction Intermediates	26	1.29e-01	2.30e-01	0.23400	-0.225000	6.41e-02	4.71e-02	5.72e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	10	1.29e-01	2.30e-01	0.38300	-0.202000	3.25e-01	2.69e-01	7.50e-02
HSF1-dependent transactivation	25	1.30e-01	2.32e-01	0.22400	0.154000	1.62e-01	1.83e-01	1.61e-01
Interleukin-12 signaling	35	1.31e-01	2.34e-01	0.18900	0.121000	1.45e-01	2.17e-01	1.38e-01
Signaling by ERBB4	31	1.32e-01	2.34e-01	0.21200	0.207000	-5.01e-02	4.68e-02	6.30e-01
FGFR1 mutant receptor activation	21	1.32e-01	2.34e-01	0.26000	0.244000	-9.17e-02	5.35e-02	4.67e-01
Termination of translesion DNA synthesis	28	1.33e-01	2.35e-01	0.21100	-0.186000	-1.01e-01	8.86e-02	3.58e-01
Mitotic Prophase	73	1.33e-01	2.35e-01	0.13700	-0.020500	1.36e-01	7.63e-01	4.52e-02
ER Quality Control Compartment (ERQC)	18	1.34e-01	2.35e-01	0.26800	0.264000	4.95e-02	5.30e-02	7.16e-01
RNA Polymerase II Pre-transcription Events	65	1.34e-01	2.35e-01	0.13900	0.059600	1.26e-01	4.07e-01	8.02e-02
Misspliced GSK3beta mutants stabilize beta-catenin	13	1.34e-01	2.35e-01	0.31200	0.294000	1.05e-01	6.70e-02	5.12e-01
S33 mutants of beta-catenin aren't phosphorylated	13	1.34e-01	2.35e-01	0.31200	0.294000	1.05e-01	6.70e-02	5.12e-01
S37 mutants of beta-catenin aren't phosphorylated	13	1.34e-01	2.35e-01	0.31200	0.294000	1.05e-01	6.70e-02	5.12e-01
S45 mutants of beta-catenin aren't phosphorylated	13	1.34e-01	2.35e-01	0.31200	0.294000	1.05e-01	6.70e-02	5.12e-01
T41 mutants of beta-catenin aren't phosphorylated	13	1.34e-01	2.35e-01	0.31200	0.294000	1.05e-01	6.70e-02	5.12e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	13	1.34e-01	2.35e-01	0.31200	0.294000	1.05e-01	6.70e-02	5.12e-01
HCMV Infection	71	1.35e-01	2.36e-01	0.13600	0.017400	1.35e-01	8.00e-01	5.04e-02
G2/M DNA damage checkpoint	53	1.35e-01	2.36e-01	0.16400	-0.149000	6.81e-02	6.12e-02	3.92e-01
Peptide hormone metabolism	26	1.35e-01	2.36e-01	0.22600	0.226000	3.18e-03	4.66e-02	9.78e-01
G2/M Checkpoints	116	1.36e-01	2.36e-01	0.10900	-0.019000	1.07e-01	7.25e-01	4.67e-02
mRNA Splicing - Minor Pathway	44	1.37e-01	2.37e-01	0.17400	-0.012100	1.74e-01	8.90e-01	4.61e-02
Resolution of Sister Chromatid Cohesion	90	1.38e-01	2.39e-01	0.12500	-0.048100	1.15e-01	4.31e-01	5.92e-02
Signaling by SCF-KIT	33	1.40e-01	2.42e-01	0.19600	0.193000	3.34e-02	5.47e-02	7.40e-01
mRNA decay by 3' to 5' exoribonuclease	14	1.41e-01	2.44e-01	0.31800	-0.217000	2.32e-01	1.59e-01	1.33e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	30	1.42e-01	2.44e-01	0.21200	0.207000	-4.48e-02	5.00e-02	6.72e-01
Ephrin signaling	12	1.44e-01	2.47e-01	0.33900	0.162000	-2.98e-01	3.32e-01	7.36e-02
Senescence-Associated Secretory Phenotype (SASP)	41	1.46e-01	2.50e-01	0.17000	0.096300	1.40e-01	2.86e-01	1.20e-01
G1/S Transition	113	1.48e-01	2.55e-01	0.10800	-0.023900	1.06e-01	6.61e-01	5.32e-02
RNA Polymerase III Chain Elongation	16	1.50e-01	2.58e-01	0.29300	-0.209000	2.05e-01	1.48e-01	1.56e-01
G beta:gamma signalling through BTK	10	1.51e-01	2.58e-01	0.34200	0.167000	2.99e-01	3.61e-01	1.02e-01
Retinoid metabolism and transport	10	1.51e-01	2.58e-01	0.35500	0.355000	-1.19e-02	5.21e-02	9.48e-01
Regulation of signaling by CBL	14	1.53e-01	2.61e-01	0.28800	0.139000	2.53e-01	3.68e-01	1.02e-01
Diseases associated with glycosylation precursor biosynthesis	18	1.54e-01	2.62e-01	0.26900	0.256000	-8.35e-02	6.01e-02	5.40e-01
Translesion synthesis by POLI	15	1.54e-01	2.62e-01	0.29900	-0.242000	1.76e-01	1.04e-01	2.39e-01
Cytochrome c-mediated apoptotic response	10	1.55e-01	2.63e-01	0.34000	0.297000	1.64e-01	1.04e-01	3.68e-01
Interleukin-12 family signaling	41	1.57e-01	2.65e-01	0.16700	0.112000	1.23e-01	2.15e-01	1.72e-01
RMTs methylate histone arginines	25	1.59e-01	2.69e-01	0.23100	-0.153000	1.73e-01	1.87e-01	1.35e-01
Cyclin A:Cdk2-associated events at S phase entry	74	1.60e-01	2.70e-01	0.12500	0.118000	4.21e-02	7.98e-02	5.32e-01
Regulation of TP53 Activity through Phosphorylation	76	1.61e-01	2.71e-01	0.13200	-0.103000	8.23e-02	1.20e-01	2.16e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	18	1.61e-01	2.72e-01	0.25100	0.223000	1.15e-01	1.01e-01	4.00e-01
PKA-mediated phosphorylation of CREB	11	1.62e-01	2.72e-01	0.34600	0.239000	-2.51e-01	1.71e-01	1.50e-01
RUNX2 regulates bone development	17	1.62e-01	2.72e-01	0.27400	0.090800	-2.58e-01	5.17e-01	6.54e-02
Negative epigenetic regulation of rRNA expression	43	1.63e-01	2.72e-01	0.17400	-0.084600	1.52e-01	3.38e-01	8.51e-02
Depolymerisation of the Nuclear Lamina	13	1.63e-01	2.73e-01	0.29500	0.267000	1.26e-01	9.62e-02	4.31e-01
Metabolism of nucleotides	69	1.64e-01	2.73e-01	0.13700	0.121000	-6.50e-02	8.35e-02	3.52e-01
RNA Polymerase I Promoter Escape	27	1.64e-01	2.73e-01	0.21900	-0.184000	1.19e-01	9.79e-02	2.84e-01
mRNA Splicing - Major Pathway	144	1.64e-01	2.73e-01	0.09330	-0.016900	9.17e-02	7.27e-01	5.85e-02
ADORA2B mediated anti-inflammatory cytokines production	30	1.64e-01	2.73e-01	0.20200	0.201000	-1.84e-02	5.73e-02	8.62e-01
RNA polymerase II transcribes snRNA genes	63	1.64e-01	2.73e-01	0.13300	0.083700	1.03e-01	2.51e-01	1.57e-01
Synthesis of IP3 and IP4 in the cytosol	15	1.65e-01	2.73e-01	0.29300	0.258000	-1.37e-01	8.34e-02	3.57e-01
Formation of HIV elongation complex in the absence of HIV Tat	36	1.66e-01	2.75e-01	0.18400	-0.020800	1.83e-01	8.29e-01	5.83e-02
NoRC negatively regulates rRNA expression	42	1.69e-01	2.79e-01	0.17400	-0.081300	1.54e-01	3.62e-01	8.51e-02
Signaling by Erythropoietin	20	1.69e-01	2.79e-01	0.24400	0.243000	-1.09e-02	5.96e-02	9.33e-01
G beta:gamma signalling through PLC beta	12	1.69e-01	2.79e-01	0.30200	0.252000	1.66e-01	1.30e-01	3.20e-01
Presynaptic function of Kainate receptors	12	1.69e-01	2.79e-01	0.30200	0.252000	1.66e-01	1.30e-01	3.20e-01
Role of LAT2/NTAL/LAB on calcium mobilization	11	1.70e-01	2.79e-01	0.33300	0.324000	-7.64e-02	6.26e-02	6.61e-01
Glycogen storage diseases	10	1.71e-01	2.80e-01	0.35700	0.290000	-2.07e-01	1.12e-01	2.57e-01
Metabolic disorders of biological oxidation enzymes	14	1.73e-01	2.83e-01	0.28400	-0.049400	-2.80e-01	7.49e-01	6.97e-02
G alpha (12/13) signalling events	40	1.73e-01	2.83e-01	0.17000	0.170000	9.45e-03	6.35e-02	9.18e-01
GAB1 signalosome	10	1.75e-01	2.85e-01	0.34200	0.341000	-1.99e-02	6.18e-02	9.13e-01
Sema4D induced cell migration and growth-cone collapse	12	1.76e-01	2.86e-01	0.31100	0.311000	-1.71e-02	6.22e-02	9.18e-01
Pausing and recovery of Tat-mediated HIV elongation	25	1.76e-01	2.86e-01	0.21400	0.004390	2.14e-01	9.70e-01	6.38e-02
Tat-mediated HIV elongation arrest and recovery	25	1.76e-01	2.86e-01	0.21400	0.004390	2.14e-01	9.70e-01	6.38e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	14	1.76e-01	2.86e-01	0.29900	0.245000	-1.70e-01	1.12e-01	2.71e-01
Leading Strand Synthesis	12	1.77e-01	2.86e-01	0.32000	-0.291000	1.32e-01	8.11e-02	4.28e-01
Polymerase switching	12	1.77e-01	2.86e-01	0.32000	-0.291000	1.32e-01	8.11e-02	4.28e-01
Estrogen-dependent gene expression	68	1.77e-01	2.86e-01	0.12600	0.064700	1.08e-01	3.57e-01	1.24e-01
Thromboxane signalling through TP receptor	14	1.77e-01	2.87e-01	0.28400	0.284000	2.15e-02	6.62e-02	8.89e-01
Translation of structural proteins	26	1.79e-01	2.89e-01	0.20500	0.055500	1.97e-01	6.24e-01	8.16e-02
Regulation of TP53 Activity through Acetylation	26	1.80e-01	2.89e-01	0.21900	-0.165000	1.44e-01	1.46e-01	2.05e-01
Erythropoietin activates RAS	11	1.81e-01	2.92e-01	0.33000	0.310000	-1.12e-01	7.50e-02	5.22e-01
RNA Polymerase III Abortive And Retractive Initiation	37	1.83e-01	2.94e-01	0.18100	-0.092600	1.56e-01	3.30e-01	1.01e-01
RNA Polymerase III Transcription	37	1.83e-01	2.94e-01	0.18100	-0.092600	1.56e-01	3.30e-01	1.01e-01
Mitotic G1 phase and G1/S transition	127	1.83e-01	2.94e-01	0.09490	-0.002250	9.48e-02	9.65e-01	6.60e-02
Mitotic G2-G2/M phases	157	1.85e-01	2.97e-01	0.08270	0.076800	3.07e-02	9.84e-02	5.09e-01
Triglyceride metabolism	16	1.86e-01	2.97e-01	0.27400	0.240000	-1.32e-01	9.70e-02	3.60e-01
GABA receptor activation	18	1.86e-01	2.97e-01	0.24200	0.226000	8.68e-02	9.67e-02	5.24e-01
Biological oxidations	78	1.87e-01	2.97e-01	0.12100	0.017400	-1.20e-01	7.91e-01	6.74e-02
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	16	1.88e-01	2.99e-01	0.26800	-0.055700	2.62e-01	7.00e-01	6.99e-02
Meiotic recombination	16	1.89e-01	3.01e-01	0.26300	-0.263000	7.57e-03	6.84e-02	9.58e-01
Metabolism of fat-soluble vitamins	12	1.90e-01	3.02e-01	0.29700	0.288000	7.19e-02	8.40e-02	6.66e-01
Cytosolic sensors of pathogen-associated DNA	51	1.92e-01	3.04e-01	0.14500	0.020900	1.43e-01	7.96e-01	7.68e-02
Signaling by FGFR1	28	1.93e-01	3.04e-01	0.19100	0.168000	9.19e-02	1.25e-01	4.00e-01
Cyclin A/B1/B2 associated events during G2/M transition	22	1.93e-01	3.04e-01	0.21600	0.088800	1.97e-01	4.71e-01	1.10e-01
Metabolism of amino acids and derivatives	219	1.94e-01	3.07e-01	0.07100	0.003270	7.09e-02	9.34e-01	7.26e-02
Metal ion SLC transporters	15	1.95e-01	3.07e-01	0.28000	0.174000	-2.20e-01	2.45e-01	1.40e-01
Oncogene Induced Senescence	30	1.95e-01	3.07e-01	0.18700	0.183000	3.80e-02	8.25e-02	7.19e-01
Post-chaperonin tubulin folding pathway	13	1.95e-01	3.07e-01	0.29700	0.278000	-1.03e-01	8.23e-02	5.21e-01
Downregulation of ERBB2 signaling	15	1.98e-01	3.11e-01	0.26100	0.245000	8.96e-02	1.01e-01	5.48e-01
TP53 Regulates Transcription of Cell Death Genes	30	1.98e-01	3.11e-01	0.19700	0.168000	-1.01e-01	1.11e-01	3.37e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	14	2.01e-01	3.14e-01	0.28200	0.271000	-7.69e-02	7.88e-02	6.19e-01
Reproduction	43	2.05e-01	3.20e-01	0.16100	-0.152000	5.29e-02	8.53e-02	5.49e-01
Signaling by Hippo	12	2.06e-01	3.20e-01	0.29600	0.296000	-7.10e-03	7.59e-02	9.66e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	23	2.07e-01	3.20e-01	0.21400	-0.214000	9.17e-03	7.63e-02	9.39e-01
Carboxyterminal post-translational modifications of tubulin	20	2.07e-01	3.20e-01	0.23600	0.216000	-9.34e-02	9.41e-02	4.70e-01
AMER1 mutants destabilize the destruction complex	12	2.07e-01	3.20e-01	0.28700	0.266000	1.06e-01	1.10e-01	5.25e-01
APC truncation mutants have impaired AXIN binding	12	2.07e-01	3.20e-01	0.28700	0.266000	1.06e-01	1.10e-01	5.25e-01
AXIN missense mutants destabilize the destruction complex	12	2.07e-01	3.20e-01	0.28700	0.266000	1.06e-01	1.10e-01	5.25e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	12	2.07e-01	3.20e-01	0.28700	0.266000	1.06e-01	1.10e-01	5.25e-01
Truncations of AMER1 destabilize the destruction complex	12	2.07e-01	3.20e-01	0.28700	0.266000	1.06e-01	1.10e-01	5.25e-01
truncated APC mutants destabilize the destruction complex	12	2.07e-01	3.20e-01	0.28700	0.266000	1.06e-01	1.10e-01	5.25e-01
Sulfur amino acid metabolism	15	2.10e-01	3.24e-01	0.26700	-0.059700	2.61e-01	6.89e-01	8.05e-02
Ca-dependent events	21	2.11e-01	3.24e-01	0.22100	0.221000	1.23e-02	8.04e-02	9.22e-01
Signaling by cytosolic FGFR1 fusion mutants	18	2.12e-01	3.26e-01	0.24800	0.218000	-1.18e-01	1.09e-01	3.88e-01
Processive synthesis on the C-strand of the telomere	17	2.12e-01	3.26e-01	0.24200	-0.236000	-5.17e-02	9.21e-02	7.12e-01
Recognition of DNA damage by PCNA-containing replication complex	26	2.13e-01	3.26e-01	0.20200	-0.198000	3.96e-02	8.05e-02	7.27e-01
Regulation of beta-cell development	14	2.13e-01	3.26e-01	0.28200	0.234000	-1.58e-01	1.30e-01	3.07e-01
Protein-protein interactions at synapses	31	2.15e-01	3.28e-01	0.18300	0.010900	-1.82e-01	9.17e-01	7.95e-02
Glutamate Neurotransmitter Release Cycle	11	2.15e-01	3.28e-01	0.30200	-0.021700	-3.02e-01	9.01e-01	8.33e-02
Translation of Replicase and Assembly of the Replication Transcription Complex	10	2.16e-01	3.30e-01	0.31900	0.319000	-3.66e-04	8.11e-02	9.98e-01
TICAM1, RIP1-mediated IKK complex recruitment	17	2.20e-01	3.35e-01	0.23900	0.233000	5.14e-02	9.59e-02	7.14e-01
Glucagon-type ligand receptors	13	2.24e-01	3.40e-01	0.26900	0.088800	2.54e-01	5.79e-01	1.13e-01
Assembly and cell surface presentation of NMDA receptors	11	2.24e-01	3.40e-01	0.28900	-0.164000	-2.38e-01	3.46e-01	1.72e-01
IKK complex recruitment mediated by RIP1	17	2.24e-01	3.40e-01	0.23700	0.230000	5.66e-02	1.01e-01	6.87e-01
HSF1 activation	21	2.28e-01	3.45e-01	0.20800	0.161000	1.32e-01	2.03e-01	2.96e-01
Pre-NOTCH Transcription and Translation	27	2.29e-01	3.45e-01	0.19900	0.144000	-1.37e-01	1.95e-01	2.19e-01
Diseases associated with N-glycosylation of proteins	15	2.29e-01	3.45e-01	0.24900	0.086000	2.33e-01	5.65e-01	1.18e-01
CD28 co-stimulation	27	2.29e-01	3.45e-01	0.19300	-0.034800	1.90e-01	7.55e-01	8.76e-02
RNA Polymerase I Transcription Termination	26	2.32e-01	3.49e-01	0.20100	-0.173000	1.02e-01	1.28e-01	3.66e-01
PKMTs methylate histone lysines	30	2.34e-01	3.52e-01	0.18700	-0.124000	1.41e-01	2.41e-01	1.83e-01
Cell junction organization	25	2.34e-01	3.52e-01	0.19800	0.197000	-1.69e-02	8.84e-02	8.84e-01
FOXO-mediated transcription	46	2.35e-01	3.52e-01	0.14500	0.145000	2.72e-04	8.98e-02	9.97e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	10	2.36e-01	3.53e-01	0.31400	0.056600	-3.09e-01	7.57e-01	9.08e-02
Neurexins and neuroligins	19	2.36e-01	3.53e-01	0.21700	-0.101000	-1.92e-01	4.47e-01	1.47e-01
Nuclear signaling by ERBB4	16	2.39e-01	3.56e-01	0.25100	0.235000	-8.70e-02	1.04e-01	5.47e-01
Regulation of pyruvate dehydrogenase (PDH) complex	11	2.39e-01	3.56e-01	0.29600	-0.023600	2.95e-01	8.92e-01	9.07e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	16	2.39e-01	3.56e-01	0.24800	-0.059100	2.41e-01	6.82e-01	9.50e-02
HCMV Late Events	51	2.42e-01	3.60e-01	0.13500	0.008400	1.35e-01	9.17e-01	9.56e-02
Initiation of Nuclear Envelope (NE) Reformation	17	2.44e-01	3.62e-01	0.23000	0.221000	6.43e-02	1.16e-01	6.46e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	62	2.44e-01	3.62e-01	0.11900	0.103000	5.97e-02	1.62e-01	4.17e-01
Signaling by FGFR1 in disease	26	2.44e-01	3.62e-01	0.19800	0.154000	-1.24e-01	1.74e-01	2.74e-01
Caspase activation via extrinsic apoptotic signalling pathway	15	2.45e-01	3.62e-01	0.24900	0.249000	4.46e-03	9.51e-02	9.76e-01
G2/M Transition	155	2.45e-01	3.62e-01	0.07590	0.069400	3.06e-02	1.38e-01	5.13e-01
Activation of NMDA receptors and postsynaptic events	42	2.52e-01	3.71e-01	0.15400	0.122000	-9.37e-02	1.71e-01	2.94e-01
Translesion synthesis by POLK	15	2.52e-01	3.71e-01	0.25600	-0.221000	1.30e-01	1.39e-01	3.82e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	12	2.56e-01	3.77e-01	0.28200	-0.264000	9.84e-02	1.13e-01	5.55e-01
ZBP1(DAI) mediated induction of type I IFNs	17	2.57e-01	3.78e-01	0.22100	0.148000	1.65e-01	2.92e-01	2.40e-01
Constitutive Signaling by Aberrant PI3K in Cancer	24	2.58e-01	3.78e-01	0.18600	0.126000	1.37e-01	2.85e-01	2.46e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	25	2.59e-01	3.79e-01	0.19800	-0.125000	1.53e-01	2.79e-01	1.86e-01
N-glycan antennae elongation in the medial/trans-Golgi	17	2.60e-01	3.81e-01	0.22700	-0.025600	-2.26e-01	8.55e-01	1.07e-01
TNFR1-induced proapoptotic signaling	11	2.61e-01	3.81e-01	0.27600	-0.253000	-1.11e-01	1.46e-01	5.24e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	2.63e-01	3.84e-01	0.25800	0.255000	3.74e-02	1.11e-01	8.15e-01
CTLA4 inhibitory signaling	16	2.66e-01	3.88e-01	0.24000	-0.068800	2.30e-01	6.34e-01	1.12e-01
FCGR3A-mediated IL10 synthesis	22	2.67e-01	3.89e-01	0.20200	0.025400	-2.00e-01	8.37e-01	1.04e-01
Intra-Golgi traffic	39	2.68e-01	3.90e-01	0.15200	0.150000	-2.79e-02	1.07e-01	7.64e-01
Activation of gene expression by SREBF (SREBP)	34	2.71e-01	3.94e-01	0.16400	0.155000	-5.26e-02	1.18e-01	5.96e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	13	2.73e-01	3.96e-01	0.25800	0.258000	-1.11e-02	1.07e-01	9.45e-01
NRAGE signals death through JNK	31	2.73e-01	3.96e-01	0.16600	0.166000	7.79e-03	1.10e-01	9.40e-01
Signaling by FGFR in disease	40	2.76e-01	4.00e-01	0.15200	0.125000	-8.67e-02	1.71e-01	3.44e-01
BBSome-mediated cargo-targeting to cilium	19	2.80e-01	4.05e-01	0.20400	-0.183000	-9.12e-02	1.68e-01	4.92e-01
Telomere C-strand synthesis initiation	10	2.80e-01	4.05e-01	0.30000	-0.270000	1.31e-01	1.39e-01	4.73e-01
Transcriptional Regulation by E2F6	29	2.82e-01	4.06e-01	0.16800	-0.166000	-2.74e-02	1.22e-01	7.98e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	22	2.85e-01	4.10e-01	0.19800	0.039200	-1.94e-01	7.51e-01	1.15e-01
RUNX2 regulates osteoblast differentiation	12	2.89e-01	4.15e-01	0.26200	-0.004340	-2.62e-01	9.79e-01	1.17e-01
Signaling by FGFR2	47	2.90e-01	4.17e-01	0.12800	0.112000	6.13e-02	1.83e-01	4.68e-01
Trafficking and processing of endosomal TLR	10	2.92e-01	4.19e-01	0.29800	0.194000	-2.26e-01	2.87e-01	2.16e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	10	2.93e-01	4.19e-01	0.29600	-0.259000	1.42e-01	1.56e-01	4.36e-01
Purine catabolism	11	2.93e-01	4.19e-01	0.28200	0.250000	-1.30e-01	1.51e-01	4.57e-01
Synthesis of substrates in N-glycan biosythesis	49	2.94e-01	4.21e-01	0.12800	0.127000	1.13e-02	1.23e-01	8.92e-01
PINK1-PRKN Mediated Mitophagy	18	2.99e-01	4.26e-01	0.20400	0.177000	1.01e-01	1.93e-01	4.61e-01
Class I peroxisomal membrane protein import	19	2.99e-01	4.26e-01	0.20900	-0.204000	4.13e-02	1.23e-01	7.55e-01
Other interleukin signaling	15	3.00e-01	4.26e-01	0.23400	0.034700	-2.31e-01	8.16e-01	1.21e-01
MicroRNA (miRNA) biogenesis	20	3.01e-01	4.28e-01	0.20200	-0.025200	2.00e-01	8.45e-01	1.22e-01
Ion transport by P-type ATPases	27	3.03e-01	4.29e-01	0.17000	0.014100	1.70e-01	8.99e-01	1.27e-01
HIV elongation arrest and recovery	26	3.03e-01	4.29e-01	0.17300	0.013900	1.73e-01	9.02e-01	1.27e-01
Pausing and recovery of HIV elongation	26	3.03e-01	4.29e-01	0.17300	0.013900	1.73e-01	9.02e-01	1.27e-01
Transcriptional Regulation by TP53	296	3.04e-01	4.29e-01	0.05160	0.010500	5.06e-02	7.59e-01	1.38e-01
Transport of vitamins, nucleosides, and related molecules	21	3.04e-01	4.29e-01	0.19800	0.043200	-1.93e-01	7.32e-01	1.26e-01
Zinc transporters	11	3.04e-01	4.29e-01	0.27800	0.139000	-2.41e-01	4.24e-01	1.67e-01
Positive epigenetic regulation of rRNA expression	40	3.07e-01	4.32e-01	0.14500	-0.133000	5.78e-02	1.47e-01	5.28e-01
The role of Nef in HIV-1 replication and disease pathogenesis	19	3.09e-01	4.35e-01	0.20400	0.203000	-2.35e-02	1.26e-01	8.60e-01
Apoptotic factor-mediated response	14	3.11e-01	4.37e-01	0.23300	0.232000	2.28e-02	1.33e-01	8.82e-01
MET promotes cell motility	13	3.11e-01	4.37e-01	0.23700	0.221000	8.66e-02	1.68e-01	5.89e-01
Insulin receptor signalling cascade	26	3.13e-01	4.39e-01	0.16700	0.149000	7.41e-02	1.88e-01	5.13e-01
Peroxisomal lipid metabolism	22	3.15e-01	4.41e-01	0.18900	0.187000	-3.25e-02	1.30e-01	7.92e-01
CaM pathway	20	3.22e-01	4.50e-01	0.19600	0.194000	-3.00e-02	1.33e-01	8.16e-01
Calmodulin induced events	20	3.22e-01	4.50e-01	0.19600	0.194000	-3.00e-02	1.33e-01	8.16e-01
Cell-Cell communication	47	3.22e-01	4.50e-01	0.12600	0.125000	1.24e-02	1.39e-01	8.84e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	15	3.24e-01	4.51e-01	0.22000	0.217000	3.78e-02	1.46e-01	8.00e-01
ECM proteoglycans	12	3.27e-01	4.55e-01	0.24300	-0.235000	-6.26e-02	1.58e-01	7.08e-01
Post NMDA receptor activation events	37	3.29e-01	4.57e-01	0.14400	0.141000	-2.73e-02	1.38e-01	7.74e-01
Citric acid cycle (TCA cycle)	19	3.29e-01	4.57e-01	0.19100	0.173000	8.11e-02	1.92e-01	5.41e-01
Pyruvate metabolism	20	3.31e-01	4.58e-01	0.18600	0.166000	8.23e-02	1.98e-01	5.25e-01
Activation of BH3-only proteins	27	3.32e-01	4.60e-01	0.15900	0.135000	8.35e-02	2.25e-01	4.53e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	10	3.35e-01	4.63e-01	0.25900	0.210000	1.53e-01	2.51e-01	4.03e-01
RAF-independent MAPK1/3 activation	20	3.35e-01	4.63e-01	0.18400	0.162000	8.79e-02	2.11e-01	4.96e-01
Activation of GABAB receptors	17	3.37e-01	4.65e-01	0.20000	0.185000	7.64e-02	1.87e-01	5.86e-01
GABA B receptor activation	17	3.37e-01	4.65e-01	0.20000	0.185000	7.64e-02	1.87e-01	5.86e-01
TRAF6 mediated NF-kB activation	18	3.39e-01	4.66e-01	0.20600	0.187000	-8.80e-02	1.71e-01	5.18e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	13	3.43e-01	4.71e-01	0.22800	0.066500	2.19e-01	6.78e-01	1.73e-01
SHC1 events in ERBB2 signaling	11	3.44e-01	4.72e-01	0.26500	0.182000	-1.93e-01	2.97e-01	2.69e-01
Mitochondrial iron-sulfur cluster biogenesis	10	3.51e-01	4.81e-01	0.25300	0.195000	1.62e-01	2.86e-01	3.75e-01
Transcriptional Regulation by MECP2	31	3.57e-01	4.88e-01	0.14700	0.145000	2.32e-02	1.63e-01	8.24e-01
RNA Pol II CTD phosphorylation and interaction with CE	23	3.57e-01	4.88e-01	0.16900	0.039000	1.65e-01	7.46e-01	1.72e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	23	3.57e-01	4.88e-01	0.16900	0.039000	1.65e-01	7.46e-01	1.72e-01
RIP-mediated NFkB activation via ZBP1	14	3.58e-01	4.88e-01	0.21200	0.158000	1.41e-01	3.05e-01	3.62e-01
TICAM1-dependent activation of IRF3/IRF7	12	3.58e-01	4.88e-01	0.23500	0.035600	2.33e-01	8.31e-01	1.63e-01
SLC transporter disorders	49	3.59e-01	4.89e-01	0.12300	-0.097800	7.45e-02	2.37e-01	3.67e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	41	3.60e-01	4.89e-01	0.12500	0.111000	5.59e-02	2.17e-01	5.36e-01
Nephrin family interactions	14	3.63e-01	4.93e-01	0.22700	-0.108000	2.00e-01	4.84e-01	1.96e-01
Mitophagy	23	3.63e-01	4.93e-01	0.17100	0.171000	-4.53e-03	1.55e-01	9.70e-01
Activation of G protein gated Potassium channels	11	3.65e-01	4.93e-01	0.23700	0.143000	1.89e-01	4.11e-01	2.78e-01
G protein gated Potassium channels	11	3.65e-01	4.93e-01	0.23700	0.143000	1.89e-01	4.11e-01	2.78e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	11	3.65e-01	4.93e-01	0.23700	0.143000	1.89e-01	4.11e-01	2.78e-01
Formation of RNA Pol II elongation complex	48	3.66e-01	4.94e-01	0.11500	0.035200	1.10e-01	6.73e-01	1.89e-01
RNA Polymerase II Transcription Elongation	48	3.66e-01	4.94e-01	0.11500	0.035200	1.10e-01	6.73e-01	1.89e-01
Downregulation of TGF-beta receptor signaling	26	3.68e-01	4.96e-01	0.16600	0.140000	-8.96e-02	2.18e-01	4.29e-01
RAS processing	15	3.70e-01	4.97e-01	0.20500	0.062100	1.95e-01	6.77e-01	1.91e-01
DNA Double Strand Break Response	34	3.71e-01	4.98e-01	0.14300	-0.054500	1.33e-01	5.83e-01	1.81e-01
Non-integrin membrane-ECM interactions	14	3.72e-01	5.00e-01	0.21100	0.070000	1.99e-01	6.51e-01	1.98e-01
Regulation of TNFR1 signaling	28	3.75e-01	5.02e-01	0.14900	-0.142000	-4.47e-02	1.93e-01	6.82e-01
Protein localization	122	3.76e-01	5.02e-01	0.07330	0.073300	8.40e-04	1.64e-01	9.87e-01
E2F mediated regulation of DNA replication	18	3.76e-01	5.02e-01	0.19700	-0.090900	1.74e-01	5.05e-01	2.00e-01
FCERI mediated Ca+2 mobilization	25	3.76e-01	5.02e-01	0.16600	0.059700	-1.55e-01	6.06e-01	1.81e-01
Signaling by PDGF	25	3.77e-01	5.03e-01	0.16100	0.161000	-1.55e-04	1.64e-01	9.99e-01
mRNA decay by 5' to 3' exoribonuclease	15	3.79e-01	5.04e-01	0.20400	-0.035700	-2.01e-01	8.11e-01	1.78e-01
Retrograde transport at the Trans-Golgi-Network	45	3.80e-01	5.04e-01	0.11800	0.117000	1.83e-02	1.76e-01	8.32e-01
Global Genome Nucleotide Excision Repair (GG-NER)	76	3.80e-01	5.04e-01	0.09390	-0.091600	2.08e-02	1.69e-01	7.55e-01
Mismatch Repair	13	3.80e-01	5.04e-01	0.23000	-0.202000	1.11e-01	2.08e-01	4.89e-01
SUMOylation of transcription cofactors	35	3.83e-01	5.07e-01	0.13400	0.008200	1.34e-01	9.33e-01	1.70e-01
Signaling by EGFR in Cancer	16	3.83e-01	5.07e-01	0.19800	0.198000	1.27e-02	1.71e-01	9.30e-01
Pexophagy	10	3.85e-01	5.09e-01	0.24700	0.242000	5.24e-02	1.86e-01	7.74e-01
Cholesterol biosynthesis	20	3.85e-01	5.09e-01	0.18400	0.168000	-7.33e-02	1.93e-01	5.70e-01
DAG and IP3 signaling	26	3.87e-01	5.10e-01	0.16200	0.098700	-1.29e-01	3.84e-01	2.55e-01
RET signaling	22	3.88e-01	5.11e-01	0.17100	0.169000	-1.91e-02	1.69e-01	8.77e-01
Amino acid transport across the plasma membrane	16	3.94e-01	5.19e-01	0.20500	0.149000	-1.41e-01	3.04e-01	3.28e-01
Signaling by ERBB2	32	3.97e-01	5.21e-01	0.13300	0.112000	7.19e-02	2.71e-01	4.82e-01
NRIF signals cell death from the nucleus	14	3.98e-01	5.21e-01	0.21600	0.194000	-9.42e-02	2.08e-01	5.42e-01
DNA Damage/Telomere Stress Induced Senescence	23	3.98e-01	5.21e-01	0.16900	-0.084400	1.47e-01	4.84e-01	2.24e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	21	3.98e-01	5.21e-01	0.16600	0.061200	1.54e-01	6.28e-01	2.22e-01
Insulin processing	17	3.99e-01	5.21e-01	0.19400	0.186000	-5.31e-02	1.84e-01	7.05e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	37	3.99e-01	5.21e-01	0.12900	0.001350	-1.29e-01	9.89e-01	1.76e-01
Synthesis of very long-chain fatty acyl-CoAs	16	4.01e-01	5.23e-01	0.19000	0.060500	1.80e-01	6.75e-01	2.13e-01
Removal of the Flap Intermediate from the C-strand	15	4.02e-01	5.24e-01	0.19900	-0.199000	-1.68e-02	1.83e-01	9.10e-01
Interleukin-20 family signaling	13	4.04e-01	5.26e-01	0.21100	0.205000	5.00e-02	2.00e-01	7.55e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	22	4.11e-01	5.35e-01	0.17000	0.094500	-1.42e-01	4.43e-01	2.50e-01
p75NTR signals via NF-kB	11	4.12e-01	5.35e-01	0.22500	0.209000	8.21e-02	2.29e-01	6.37e-01
CDC6 association with the ORC:origin complex	10	4.14e-01	5.37e-01	0.24600	-0.054000	2.40e-01	7.67e-01	1.89e-01
Nuclear Envelope (NE) Reassembly	60	4.16e-01	5.40e-01	0.09490	0.062300	7.15e-02	4.05e-01	3.39e-01
B-WICH complex positively regulates rRNA expression	27	4.17e-01	5.40e-01	0.14600	-0.146000	-5.78e-03	1.89e-01	9.59e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	14	4.19e-01	5.42e-01	0.21200	-0.153000	1.46e-01	3.21e-01	3.43e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	33	4.20e-01	5.42e-01	0.13600	-0.043500	1.29e-01	6.66e-01	2.02e-01
PIWI-interacting RNA (piRNA) biogenesis	15	4.20e-01	5.42e-01	0.20200	-0.082800	1.85e-01	5.79e-01	2.16e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	12	4.23e-01	5.45e-01	0.22100	0.218000	-3.87e-02	1.92e-01	8.16e-01
Trafficking of AMPA receptors	12	4.23e-01	5.45e-01	0.22100	0.218000	-3.87e-02	1.92e-01	8.16e-01
Collagen biosynthesis and modifying enzymes	17	4.29e-01	5.51e-01	0.18800	0.168000	-8.44e-02	2.30e-01	5.47e-01
Metabolism of porphyrins	15	4.31e-01	5.53e-01	0.18600	0.143000	1.18e-01	3.38e-01	4.28e-01
Inwardly rectifying K+ channels	12	4.32e-01	5.54e-01	0.20800	0.114000	1.74e-01	4.95e-01	2.97e-01
Signaling by FGFR	51	4.32e-01	5.54e-01	0.10100	0.090500	4.57e-02	2.65e-01	5.73e-01
Activation of kainate receptors upon glutamate binding	16	4.33e-01	5.55e-01	0.17900	0.147000	1.03e-01	3.09e-01	4.77e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	12	4.39e-01	5.62e-01	0.21700	-0.211000	5.19e-02	2.06e-01	7.56e-01
Formation of TC-NER Pre-Incision Complex	45	4.41e-01	5.63e-01	0.10700	0.040100	9.93e-02	6.42e-01	2.50e-01
Elastic fibre formation	17	4.42e-01	5.64e-01	0.18600	0.101000	-1.56e-01	4.71e-01	2.67e-01
APC/C:Cdc20 mediated degradation of Cyclin B	22	4.44e-01	5.65e-01	0.15400	0.037800	1.49e-01	7.59e-01	2.27e-01
VEGFR2 mediated vascular permeability	22	4.44e-01	5.65e-01	0.15100	0.085000	1.25e-01	4.91e-01	3.12e-01
Fatty acyl-CoA biosynthesis	26	4.48e-01	5.69e-01	0.13900	0.054400	1.28e-01	6.32e-01	2.58e-01
Metalloprotease DUBs	16	4.49e-01	5.70e-01	0.18700	0.178000	-5.77e-02	2.19e-01	6.90e-01
Signaling by WNT in cancer	22	4.52e-01	5.73e-01	0.15100	0.145000	4.43e-02	2.40e-01	7.19e-01
Synthesis of PIPs at the plasma membrane	36	4.53e-01	5.74e-01	0.11800	0.110000	4.25e-02	2.55e-01	6.60e-01
Cardiac conduction	42	4.58e-01	5.79e-01	0.10900	-0.026700	-1.06e-01	7.65e-01	2.36e-01
Ovarian tumor domain proteases	28	4.58e-01	5.79e-01	0.14000	0.129000	-5.48e-02	2.37e-01	6.16e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	54	4.60e-01	5.80e-01	0.10200	-0.084100	5.77e-02	2.86e-01	4.64e-01
Interferon gamma signaling	55	4.60e-01	5.80e-01	0.10100	-0.076300	6.66e-02	3.29e-01	3.94e-01
Regulation of IFNA signaling	12	4.71e-01	5.93e-01	0.19600	0.134000	1.43e-01	4.22e-01	3.91e-01
PI Metabolism	59	4.72e-01	5.93e-01	0.08860	0.064600	6.06e-02	3.92e-01	4.22e-01
Regulation of TP53 Activity through Methylation	17	4.79e-01	6.02e-01	0.16800	-0.166000	-2.11e-02	2.35e-01	8.81e-01
NOD1/2 Signaling Pathway	23	4.80e-01	6.02e-01	0.14100	0.122000	7.02e-02	3.12e-01	5.60e-01
Netrin-1 signaling	25	4.80e-01	6.02e-01	0.13400	-0.109000	-7.88e-02	3.46e-01	4.96e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	10	4.84e-01	6.06e-01	0.21200	0.108000	1.82e-01	5.54e-01	3.19e-01
Interconversion of nucleotide di- and triphosphates	22	4.87e-01	6.10e-01	0.15400	0.096100	-1.20e-01	4.35e-01	3.31e-01
RUNX3 regulates NOTCH signaling	11	4.90e-01	6.12e-01	0.20900	0.208000	-2.12e-02	2.32e-01	9.03e-01
Anchoring of the basal body to the plasma membrane	80	4.93e-01	6.15e-01	0.07870	-0.075500	2.23e-02	2.44e-01	7.30e-01
Meiotic synapsis	23	4.96e-01	6.19e-01	0.14800	-0.118000	8.90e-02	3.26e-01	4.60e-01
APC-Cdc20 mediated degradation of Nek2A	24	4.97e-01	6.19e-01	0.14100	-0.019900	1.39e-01	8.66e-01	2.38e-01
Signalling to RAS	13	5.05e-01	6.28e-01	0.18400	0.183000	2.67e-02	2.55e-01	8.68e-01
Phase I - Functionalization of compounds	30	5.06e-01	6.28e-01	0.12000	-0.032300	-1.16e-01	7.59e-01	2.72e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	11	5.06e-01	6.28e-01	0.19500	-0.125000	-1.50e-01	4.74e-01	3.90e-01
DNA Damage Bypass	41	5.11e-01	6.33e-01	0.10300	-0.102000	-1.51e-02	2.59e-01	8.67e-01
Phase II - Conjugation of compounds	45	5.11e-01	6.34e-01	0.10400	0.055100	-8.77e-02	5.23e-01	3.10e-01
Metabolism of cofactors	17	5.12e-01	6.34e-01	0.15900	0.157000	2.70e-02	2.62e-01	8.47e-01
Regulation of FZD by ubiquitination	11	5.20e-01	6.43e-01	0.20600	0.176000	-1.08e-01	3.13e-01	5.37e-01
Metabolism of nitric oxide: NOS3 activation and regulation	11	5.21e-01	6.43e-01	0.20500	0.186000	-8.68e-02	2.86e-01	6.18e-01
Elevation of cytosolic Ca2+ levels	10	5.22e-01	6.44e-01	0.21600	0.124000	-1.77e-01	4.96e-01	3.33e-01
G alpha (s) signalling events	44	5.26e-01	6.48e-01	0.10200	0.089800	-4.86e-02	3.03e-01	5.77e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	19	5.31e-01	6.53e-01	0.15400	-0.068900	1.38e-01	6.03e-01	2.99e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	19	5.31e-01	6.53e-01	0.15400	-0.068900	1.38e-01	6.03e-01	2.99e-01
DCC mediated attractive signaling	11	5.35e-01	6.57e-01	0.18800	-0.165000	-8.96e-02	3.44e-01	6.07e-01
Formation of the beta-catenin:TCF transactivating complex	24	5.46e-01	6.69e-01	0.12900	0.006410	1.29e-01	9.57e-01	2.75e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	68	5.46e-01	6.69e-01	0.08040	-0.059500	5.41e-02	3.97e-01	4.41e-01
Molecules associated with elastic fibres	12	5.47e-01	6.69e-01	0.17900	-0.050900	-1.71e-01	7.60e-01	3.04e-01
Processing of SMDT1	12	5.49e-01	6.70e-01	0.17500	0.132000	1.15e-01	4.27e-01	4.92e-01
Transcriptional regulation by RUNX1	133	5.49e-01	6.70e-01	0.05400	0.052700	1.21e-02	2.96e-01	8.10e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	22	5.50e-01	6.70e-01	0.13500	-0.011800	1.35e-01	9.24e-01	2.74e-01
Disorders of developmental biology	10	5.51e-01	6.70e-01	0.20700	0.174000	-1.11e-01	3.40e-01	5.44e-01
Loss of function of MECP2 in Rett syndrome	10	5.51e-01	6.70e-01	0.20700	0.174000	-1.11e-01	3.40e-01	5.44e-01
Pervasive developmental disorders	10	5.51e-01	6.70e-01	0.20700	0.174000	-1.11e-01	3.40e-01	5.44e-01
Chaperone Mediated Autophagy	12	5.52e-01	6.71e-01	0.17400	0.128000	1.18e-01	4.43e-01	4.80e-01
Caspase-mediated cleavage of cytoskeletal proteins	10	5.54e-01	6.72e-01	0.19300	0.057900	1.85e-01	7.51e-01	3.12e-01
Nucleotide Excision Repair	98	5.58e-01	6.76e-01	0.06450	-0.062400	1.63e-02	2.87e-01	7.81e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	18	5.58e-01	6.76e-01	0.15100	-0.053700	1.41e-01	6.94e-01	3.01e-01
Platelet calcium homeostasis	17	5.63e-01	6.79e-01	0.15600	0.133000	-8.03e-02	3.42e-01	5.67e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	14	5.64e-01	6.79e-01	0.15900	0.128000	9.43e-02	4.09e-01	5.41e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	14	5.64e-01	6.79e-01	0.15900	0.128000	9.43e-02	4.09e-01	5.41e-01
Keratan sulfate/keratin metabolism	19	5.64e-01	6.79e-01	0.14000	0.140000	1.44e-02	2.93e-01	9.13e-01
NOTCH4 Intracellular Domain Regulates Transcription	14	5.64e-01	6.79e-01	0.17200	0.101000	-1.39e-01	5.15e-01	3.68e-01
Adrenaline,noradrenaline inhibits insulin secretion	14	5.64e-01	6.79e-01	0.16000	0.058900	1.49e-01	7.03e-01	3.35e-01
VEGFR2 mediated cell proliferation	16	5.67e-01	6.81e-01	0.15800	0.065600	-1.44e-01	6.50e-01	3.18e-01
Dual incision in TC-NER	55	5.72e-01	6.86e-01	0.08550	-0.073100	4.43e-02	3.49e-01	5.71e-01
Formation of Incision Complex in GG-NER	36	5.78e-01	6.92e-01	0.10400	-0.044600	9.40e-02	6.43e-01	3.30e-01
mRNA Capping	25	5.78e-01	6.92e-01	0.12100	-0.004700	1.21e-01	9.68e-01	2.96e-01
Integrin cell surface interactions	25	5.81e-01	6.95e-01	0.12000	0.119000	6.63e-03	3.02e-01	9.54e-01
RORA activates gene expression	10	5.85e-01	6.99e-01	0.19600	0.167000	-1.02e-01	3.59e-01	5.78e-01
Regulation of RUNX1 Expression and Activity	15	5.87e-01	7.00e-01	0.14800	-0.099700	-1.09e-01	5.04e-01	4.66e-01
Transcriptional Regulation by VENTX	30	5.87e-01	7.00e-01	0.11000	-0.108000	2.12e-02	3.05e-01	8.41e-01
Nuclear Receptor transcription pathway	26	5.88e-01	7.00e-01	0.12100	-0.107000	5.49e-02	3.44e-01	6.28e-01
Glutathione conjugation	20	5.89e-01	7.00e-01	0.13800	0.114000	-7.72e-02	3.76e-01	5.50e-01
Deactivation of the beta-catenin transactivating complex	28	5.89e-01	7.00e-01	0.10800	0.083900	6.76e-02	4.43e-01	5.36e-01
Metabolism of water-soluble vitamins and cofactors	79	5.90e-01	7.00e-01	0.06570	-0.064300	-1.36e-02	3.24e-01	8.35e-01
NCAM signaling for neurite out-growth	22	5.92e-01	7.03e-01	0.12500	-0.125000	-4.02e-03	3.09e-01	9.74e-01
Nicotinamide salvaging	11	5.94e-01	7.04e-01	0.18500	-0.123000	1.38e-01	4.79e-01	4.29e-01
Ca2+ pathway	39	5.94e-01	7.04e-01	0.09120	0.081100	4.16e-02	3.81e-01	6.53e-01
Tie2 Signaling	10	5.96e-01	7.05e-01	0.18600	0.185000	-5.31e-03	3.10e-01	9.77e-01
Base-Excision Repair, AP Site Formation	13	5.98e-01	7.07e-01	0.15700	-0.144000	-6.26e-02	3.68e-01	6.96e-01
NOTCH3 Intracellular Domain Regulates Transcription	15	6.03e-01	7.12e-01	0.14700	0.144000	3.11e-02	3.35e-01	8.35e-01
Mitochondrial translation initiation	83	6.10e-01	7.20e-01	0.06070	-0.050000	-3.45e-02	4.33e-01	5.87e-01
RNA Polymerase III Transcription Termination	20	6.14e-01	7.23e-01	0.13200	-0.064200	1.15e-01	6.20e-01	3.72e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	26	6.20e-01	7.29e-01	0.10600	-0.067200	-8.23e-02	5.53e-01	4.68e-01
Vitamin B5 (pantothenate) metabolism	11	6.20e-01	7.29e-01	0.17200	0.169000	-3.15e-02	3.31e-01	8.57e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	34	6.24e-01	7.32e-01	0.09360	-0.088000	-3.21e-02	3.75e-01	7.46e-01
Synthesis of PIPs at the early endosome membrane	12	6.26e-01	7.35e-01	0.16300	-0.028000	1.61e-01	8.67e-01	3.35e-01
Deadenylation of mRNA	21	6.28e-01	7.36e-01	0.12300	0.121000	-2.11e-02	3.37e-01	8.67e-01
CD209 (DC-SIGN) signaling	15	6.31e-01	7.39e-01	0.13800	0.124000	6.15e-02	4.07e-01	6.80e-01
Interleukin-37 signaling	17	6.37e-01	7.45e-01	0.13600	0.036600	-1.30e-01	7.94e-01	3.52e-01
Caspase activation via Death Receptors in the presence of ligand	10	6.38e-01	7.45e-01	0.17300	0.173000	-4.30e-05	3.45e-01	1.00e+00
SUMOylation of DNA methylation proteins	14	6.40e-01	7.45e-01	0.14700	-0.024100	1.45e-01	8.76e-01	3.46e-01
Assembly of collagen fibrils and other multimeric structures	14	6.40e-01	7.45e-01	0.14800	0.145000	-3.17e-02	3.49e-01	8.38e-01
Activation of HOX genes during differentiation	38	6.41e-01	7.45e-01	0.09120	0.039000	-8.24e-02	6.78e-01	3.80e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	38	6.41e-01	7.45e-01	0.09120	0.039000	-8.24e-02	6.78e-01	3.80e-01
Bile acid and bile salt metabolism	14	6.41e-01	7.45e-01	0.14800	0.031400	-1.44e-01	8.39e-01	3.50e-01
TNFR1-induced NFkappaB signaling pathway	19	6.47e-01	7.51e-01	0.12600	-0.122000	2.88e-02	3.57e-01	8.28e-01
G1/S-Specific Transcription	25	6.48e-01	7.52e-01	0.11200	-0.092800	6.21e-02	4.23e-01	5.91e-01
Signaling by ERBB2 KD Mutants	11	6.52e-01	7.56e-01	0.15800	-0.025400	-1.56e-01	8.84e-01	3.69e-01
Mitochondrial Fatty Acid Beta-Oxidation	25	6.53e-01	7.56e-01	0.10500	-0.014800	-1.04e-01	8.98e-01	3.68e-01
Interleukin-7 signaling	14	6.56e-01	7.58e-01	0.13600	0.118000	6.81e-02	4.44e-01	6.59e-01
Mitochondrial translation elongation	83	6.56e-01	7.58e-01	0.05680	-0.053700	-1.84e-02	3.99e-01	7.73e-01
TRAF6 mediated IRF7 activation	15	6.60e-01	7.62e-01	0.13800	0.029700	-1.35e-01	8.42e-01	3.67e-01
Mitochondrial translation termination	82	6.64e-01	7.65e-01	0.05570	-0.047300	-2.94e-02	4.60e-01	6.46e-01
Post-translational modification: synthesis of GPI-anchored proteins	28	6.71e-01	7.72e-01	0.09890	0.018900	-9.71e-02	8.63e-01	3.74e-01
Regulation of MECP2 expression and activity	23	6.72e-01	7.73e-01	0.10400	0.098300	3.52e-02	4.15e-01	7.70e-01
Mitochondrial protein import	47	6.75e-01	7.74e-01	0.07160	-0.050400	-5.10e-02	5.51e-01	5.46e-01
Downstream signal transduction	21	6.76e-01	7.74e-01	0.11500	0.107000	-4.17e-02	3.98e-01	7.41e-01
Glycolysis	57	6.76e-01	7.74e-01	0.06510	0.036300	5.41e-02	6.36e-01	4.81e-01
Negative regulators of DDX58/IFIH1 signaling	33	6.76e-01	7.74e-01	0.09130	-0.033000	8.51e-02	7.43e-01	3.98e-01
Signaling by KIT in disease	17	6.77e-01	7.74e-01	0.12800	-0.112000	6.25e-02	4.26e-01	6.56e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	17	6.77e-01	7.74e-01	0.12800	-0.112000	6.25e-02	4.26e-01	6.56e-01
RIPK1-mediated regulated necrosis	13	6.83e-01	7.79e-01	0.14000	0.140000	-9.83e-03	3.83e-01	9.51e-01
Regulated Necrosis	13	6.83e-01	7.79e-01	0.14000	0.140000	-9.83e-03	3.83e-01	9.51e-01
Chondroitin sulfate/dermatan sulfate metabolism	26	6.84e-01	7.79e-01	0.10300	0.070100	-7.53e-02	5.36e-01	5.07e-01
DAP12 interactions	23	6.93e-01	7.88e-01	0.09960	0.088100	4.65e-02	4.65e-01	7.00e-01
Long-term potentiation	10	6.93e-01	7.88e-01	0.15000	-0.098600	-1.13e-01	5.89e-01	5.37e-01
Purine salvage	11	6.98e-01	7.93e-01	0.15200	0.140000	-5.86e-02	4.21e-01	7.37e-01
Mitochondrial calcium ion transport	18	7.03e-01	7.97e-01	0.11100	0.106000	3.49e-02	4.38e-01	7.98e-01
NR1H2 and NR1H3-mediated signaling	26	7.04e-01	7.98e-01	0.09130	0.074500	5.28e-02	5.11e-01	6.42e-01
Heparan sulfate/heparin (HS-GAG) metabolism	19	7.06e-01	7.99e-01	0.11500	0.057900	-9.88e-02	6.62e-01	4.56e-01
SUMOylation of intracellular receptors	19	7.08e-01	8.01e-01	0.11000	0.110000	6.57e-04	4.08e-01	9.96e-01
Nicotinate metabolism	19	7.09e-01	8.01e-01	0.11300	-0.105000	4.22e-02	4.30e-01	7.50e-01
PI3K Cascade	18	7.09e-01	8.01e-01	0.11200	0.008480	1.11e-01	9.50e-01	4.13e-01
Metabolism of folate and pterines	11	7.11e-01	8.01e-01	0.13800	0.096800	9.81e-02	5.79e-01	5.73e-01
Telomere Extension By Telomerase	20	7.11e-01	8.01e-01	0.11000	-0.097300	5.17e-02	4.52e-01	6.89e-01
Diseases associated with glycosaminoglycan metabolism	15	7.14e-01	8.03e-01	0.12700	0.110000	-6.33e-02	4.62e-01	6.71e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	19	7.14e-01	8.03e-01	0.11300	0.067700	-9.04e-02	6.10e-01	4.95e-01
Inactivation, recovery and regulation of the phototransduction cascade	16	7.21e-01	8.08e-01	0.12100	-0.105000	5.97e-02	4.67e-01	6.79e-01
The phototransduction cascade	16	7.21e-01	8.08e-01	0.12100	-0.105000	5.97e-02	4.67e-01	6.79e-01
Diseases of glycosylation	68	7.21e-01	8.08e-01	0.05560	0.013700	5.39e-02	8.46e-01	4.43e-01
Translesion Synthesis by POLH	16	7.22e-01	8.08e-01	0.12100	-0.098800	7.00e-02	4.94e-01	6.28e-01
Synthesis of glycosylphosphatidylinositol (GPI)	13	7.24e-01	8.10e-01	0.12500	-0.119000	-3.99e-02	4.59e-01	8.04e-01
DNA Damage Recognition in GG-NER	35	7.24e-01	8.10e-01	0.07640	-0.072300	-2.45e-02	4.59e-01	8.02e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	15	7.30e-01	8.15e-01	0.11300	-0.083100	-7.71e-02	5.78e-01	6.05e-01
Kinesins	31	7.30e-01	8.15e-01	0.08140	-0.007770	-8.11e-02	9.40e-01	4.35e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	27	7.35e-01	8.18e-01	0.08460	-0.078600	-3.13e-02	4.80e-01	7.79e-01
Recruitment of NuMA to mitotic centrosomes	64	7.38e-01	8.18e-01	0.05660	-0.056500	3.74e-03	4.35e-01	9.59e-01
Synthesis of PA	18	7.38e-01	8.18e-01	0.10600	-0.106000	1.32e-03	4.36e-01	9.92e-01
HDMs demethylate histones	13	7.38e-01	8.18e-01	0.12100	0.049500	1.10e-01	7.57e-01	4.92e-01
Centrosome maturation	65	7.38e-01	8.18e-01	0.05750	-0.053300	2.16e-02	4.58e-01	7.64e-01
Recruitment of mitotic centrosome proteins and complexes	65	7.38e-01	8.18e-01	0.05750	-0.053300	2.16e-02	4.58e-01	7.64e-01
Signaling by ERBB2 in Cancer	12	7.40e-01	8.19e-01	0.13300	0.046000	-1.25e-01	7.83e-01	4.55e-01
Early Phase of HIV Life Cycle	13	7.41e-01	8.20e-01	0.12500	-0.124000	1.16e-02	4.39e-01	9.42e-01
Nonhomologous End-Joining (NHEJ)	28	7.42e-01	8.21e-01	0.08610	-0.082400	2.49e-02	4.51e-01	8.20e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	22	7.46e-01	8.24e-01	0.09050	0.051800	7.42e-02	6.74e-01	5.47e-01
FOXO-mediated transcription of cell cycle genes	13	7.48e-01	8.25e-01	0.11800	-0.051900	-1.06e-01	7.46e-01	5.08e-01
Signaling by NTRK2 (TRKB)	16	7.48e-01	8.25e-01	0.10600	0.089000	5.71e-02	5.38e-01	6.93e-01
Regulation of KIT signaling	11	7.50e-01	8.26e-01	0.13600	-0.057200	1.23e-01	7.43e-01	4.79e-01
Heme biosynthesis	10	7.52e-01	8.27e-01	0.13300	0.072400	1.11e-01	6.92e-01	5.43e-01
Glucose metabolism	72	7.56e-01	8.31e-01	0.05010	0.049100	9.80e-03	4.72e-01	8.86e-01
RNA Polymerase II Transcription Termination	42	7.58e-01	8.32e-01	0.06380	0.039100	5.04e-02	6.61e-01	5.73e-01
Interleukin-2 family signaling	29	7.60e-01	8.34e-01	0.08220	0.072200	-3.94e-02	5.01e-01	7.14e-01
Mitochondrial translation	88	7.64e-01	8.37e-01	0.04360	-0.035100	-2.58e-02	5.70e-01	6.76e-01
ATF4 activates genes in response to endoplasmic reticulum stress	23	7.67e-01	8.40e-01	0.08480	0.036000	7.68e-02	7.65e-01	5.24e-01
Circadian Clock	50	7.74e-01	8.47e-01	0.06080	0.049800	-3.49e-02	5.43e-01	6.70e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	12	7.80e-01	8.52e-01	0.11400	0.045700	1.04e-01	7.84e-01	5.32e-01
Ion homeostasis	26	7.82e-01	8.54e-01	0.07720	-0.026100	-7.26e-02	8.18e-01	5.22e-01
Branched-chain amino acid catabolism	19	7.88e-01	8.58e-01	0.09210	-0.091500	9.96e-03	4.90e-01	9.40e-01
Constitutive Signaling by EGFRvIII	10	7.89e-01	8.58e-01	0.12100	0.104000	6.25e-02	5.70e-01	7.32e-01
Signaling by EGFRvIII in Cancer	10	7.89e-01	8.58e-01	0.12100	0.104000	6.25e-02	5.70e-01	7.32e-01
DAP12 signaling	21	7.91e-01	8.60e-01	0.08630	0.086200	-2.84e-03	4.94e-01	9.82e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	23	7.94e-01	8.63e-01	0.07860	0.066100	4.26e-02	5.84e-01	7.24e-01
Interleukin-35 Signalling	11	7.96e-01	8.63e-01	0.11600	-0.116000	-1.26e-02	5.07e-01	9.42e-01
Synthesis of bile acids and bile salts	13	7.96e-01	8.63e-01	0.11100	0.045000	-1.02e-01	7.79e-01	5.25e-01
Glyoxylate metabolism and glycine degradation	19	7.98e-01	8.64e-01	0.08890	-0.000918	8.89e-02	9.94e-01	5.03e-01
Cytosolic sulfonation of small molecules	10	7.98e-01	8.64e-01	0.11900	0.109000	4.65e-02	5.50e-01	7.99e-01
KSRP (KHSRP) binds and destabilizes mRNA	15	8.01e-01	8.66e-01	0.10100	-0.028300	9.74e-02	8.49e-01	5.14e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	18	8.04e-01	8.68e-01	0.09090	-0.013800	8.99e-02	9.19e-01	5.09e-01
mRNA 3'-end processing	35	8.08e-01	8.72e-01	0.06160	0.027900	5.49e-02	7.75e-01	5.75e-01
Cleavage of the damaged pyrimidine	12	8.16e-01	8.78e-01	0.10200	-0.087900	-5.22e-02	5.98e-01	7.54e-01
Depyrimidination	12	8.16e-01	8.78e-01	0.10200	-0.087900	-5.22e-02	5.98e-01	7.54e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	12	8.16e-01	8.78e-01	0.10200	-0.087900	-5.22e-02	5.98e-01	7.54e-01
N-Glycan antennae elongation	11	8.19e-01	8.79e-01	0.10800	-0.028700	-1.04e-01	8.69e-01	5.52e-01
Cytochrome P450 - arranged by substrate type	14	8.19e-01	8.79e-01	0.09380	0.077100	5.33e-02	6.17e-01	7.30e-01
Signaling by Retinoic Acid	17	8.26e-01	8.87e-01	0.08800	0.021200	-8.54e-02	8.80e-01	5.42e-01
Signaling by ERBB2 ECD mutants	10	8.29e-01	8.88e-01	0.10700	-0.071700	-7.95e-02	6.95e-01	6.64e-01
Endosomal/Vacuolar pathway	11	8.30e-01	8.88e-01	0.10500	-0.105000	-1.13e-02	5.48e-01	9.48e-01
Cell surface interactions at the vascular wall	57	8.33e-01	8.91e-01	0.04720	0.045500	-1.26e-02	5.53e-01	8.70e-01
G0 and Early G1	24	8.33e-01	8.91e-01	0.07410	-0.056400	4.81e-02	6.33e-01	6.83e-01
Cargo trafficking to the periciliary membrane	40	8.36e-01	8.93e-01	0.05270	0.026700	4.54e-02	7.70e-01	6.20e-01
Phosphorylation of the APC/C	18	8.38e-01	8.93e-01	0.08090	-0.000658	8.09e-02	9.96e-01	5.53e-01
SUMOylation of transcription factors	12	8.39e-01	8.94e-01	0.10300	0.082100	-6.15e-02	6.23e-01	7.12e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	33	8.40e-01	8.94e-01	0.05730	0.026200	5.10e-02	7.94e-01	6.13e-01
Role of phospholipids in phagocytosis	16	8.50e-01	9.05e-01	0.08560	0.061200	-5.98e-02	6.72e-01	6.79e-01
Processing of Intronless Pre-mRNAs	14	8.52e-01	9.05e-01	0.08410	-0.071600	-4.41e-02	6.43e-01	7.75e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	13	8.54e-01	9.07e-01	0.08610	0.056800	6.47e-02	7.23e-01	6.86e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	16	8.56e-01	9.07e-01	0.08150	0.016200	-7.99e-02	9.10e-01	5.80e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	16	8.56e-01	9.07e-01	0.08150	0.016200	-7.99e-02	9.10e-01	5.80e-01
TNF signaling	36	8.61e-01	9.11e-01	0.05470	-0.046500	2.88e-02	6.30e-01	7.65e-01
Regulation of innate immune responses to cytosolic DNA	12	8.62e-01	9.11e-01	0.09120	-0.006040	9.10e-02	9.71e-01	5.85e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	16	8.64e-01	9.13e-01	0.08110	0.048500	-6.50e-02	7.37e-01	6.53e-01
PERK regulates gene expression	26	8.65e-01	9.13e-01	0.05840	0.039400	4.31e-02	7.28e-01	7.04e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	13	8.66e-01	9.14e-01	0.08310	-0.076700	-3.21e-02	6.32e-01	8.41e-01
Transcriptional activation of mitochondrial biogenesis	36	8.68e-01	9.14e-01	0.05190	-0.050900	9.88e-03	5.98e-01	9.18e-01
Class B/2 (Secretin family receptors)	26	8.69e-01	9.14e-01	0.06250	0.039300	-4.86e-02	7.29e-01	6.68e-01
Diseases of metabolism	120	8.70e-01	9.14e-01	0.02920	0.022000	-1.91e-02	6.78e-01	7.18e-01
Mitochondrial biogenesis	50	8.72e-01	9.16e-01	0.04140	-0.017800	-3.74e-02	8.28e-01	6.48e-01
RUNX3 regulates p14-ARF	10	8.75e-01	9.19e-01	0.09670	0.090900	-3.30e-02	6.19e-01	8.57e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	18	8.78e-01	9.21e-01	0.07200	-0.037700	6.13e-02	7.82e-01	6.52e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	12	8.89e-01	9.31e-01	0.08140	-0.081000	7.13e-03	6.27e-01	9.66e-01
Synthesis of PIPs at the Golgi membrane	12	8.91e-01	9.33e-01	0.08040	-0.005630	8.02e-02	9.73e-01	6.31e-01
STING mediated induction of host immune responses	10	8.92e-01	9.33e-01	0.08640	0.086000	8.19e-03	6.38e-01	9.64e-01
Signaling by FGFR2 IIIa TM	14	8.98e-01	9.39e-01	0.07270	0.070700	-1.69e-02	6.47e-01	9.13e-01
Cell-cell junction organization	12	9.05e-01	9.45e-01	0.07700	0.038600	-6.66e-02	8.17e-01	6.90e-01
Signaling by NTRK3 (TRKC)	12	9.12e-01	9.51e-01	0.07350	0.027600	-6.82e-02	8.69e-01	6.83e-01
Cyclin D associated events in G1	41	9.17e-01	9.54e-01	0.03900	0.019700	-3.36e-02	8.28e-01	7.10e-01
G1 Phase	41	9.17e-01	9.54e-01	0.03900	0.019700	-3.36e-02	8.28e-01	7.10e-01
Termination of O-glycan biosynthesis	10	9.20e-01	9.57e-01	0.07220	0.065600	3.01e-02	7.20e-01	8.69e-01
Potassium Channels	25	9.24e-01	9.60e-01	0.04420	0.025700	3.60e-02	8.24e-01	7.56e-01
Interleukin receptor SHC signaling	16	9.25e-01	9.60e-01	0.05650	0.056300	4.79e-03	6.97e-01	9.74e-01
Transcription of E2F targets under negative control by DREAM complex	18	9.27e-01	9.61e-01	0.05520	-0.045000	3.19e-02	7.41e-01	8.15e-01
Regulation of necroptotic cell death	11	9.30e-01	9.63e-01	0.06620	0.066200	1.54e-03	7.04e-01	9.93e-01
O-linked glycosylation	42	9.32e-01	9.63e-01	0.03290	-0.032300	-6.02e-03	7.18e-01	9.46e-01
IRS-mediated signalling	21	9.32e-01	9.63e-01	0.04710	-0.000584	4.71e-02	9.96e-01	7.09e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	10	9.33e-01	9.63e-01	0.06690	0.065300	1.45e-02	7.21e-01	9.37e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	33	9.35e-01	9.63e-01	0.03830	-0.026800	2.74e-02	7.90e-01	7.86e-01
Diseases of mitotic cell cycle	33	9.35e-01	9.63e-01	0.03830	-0.026800	2.74e-02	7.90e-01	7.86e-01
CLEC7A (Dectin-1) induces NFAT activation	11	9.36e-01	9.63e-01	0.06580	-0.053300	3.85e-02	7.59e-01	8.25e-01
Loss of Nlp from mitotic centrosomes	56	9.36e-01	9.63e-01	0.02820	-0.028100	2.51e-03	7.17e-01	9.74e-01
Loss of proteins required for interphase microtubule organization from the centrosome	56	9.36e-01	9.63e-01	0.02820	-0.028100	2.51e-03	7.17e-01	9.74e-01
Downstream signaling of activated FGFR1	12	9.40e-01	9.63e-01	0.05650	0.049800	2.67e-02	7.65e-01	8.73e-01
Downstream signaling of activated FGFR2	12	9.40e-01	9.63e-01	0.05650	0.049800	2.67e-02	7.65e-01	8.73e-01
Downstream signaling of activated FGFR3	12	9.40e-01	9.63e-01	0.05650	0.049800	2.67e-02	7.65e-01	8.73e-01
Downstream signaling of activated FGFR4	12	9.40e-01	9.63e-01	0.05650	0.049800	2.67e-02	7.65e-01	8.73e-01
IGF1R signaling cascade	23	9.42e-01	9.63e-01	0.04100	0.040000	8.90e-03	7.40e-01	9.41e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	23	9.42e-01	9.63e-01	0.04100	0.040000	8.90e-03	7.40e-01	9.41e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	55	9.44e-01	9.65e-01	0.02550	0.014800	2.08e-02	8.50e-01	7.90e-01
Signaling by BMP	14	9.46e-01	9.65e-01	0.05010	-0.019100	-4.63e-02	9.01e-01	7.64e-01
Polo-like kinase mediated events	15	9.47e-01	9.66e-01	0.04840	0.047600	8.84e-03	7.50e-01	9.53e-01
FGFR2 mutant receptor activation	15	9.50e-01	9.68e-01	0.04610	0.025800	3.82e-02	8.63e-01	7.98e-01
Signaling by PDGFR in disease	16	9.56e-01	9.73e-01	0.04180	0.024400	3.40e-02	8.66e-01	8.14e-01
Basigin interactions	14	9.56e-01	9.73e-01	0.04810	-0.035400	3.25e-02	8.18e-01	8.33e-01
Association of TriC/CCT with target proteins during biosynthesis	29	9.57e-01	9.73e-01	0.03060	0.013000	2.77e-02	9.04e-01	7.96e-01
Miscellaneous transport and binding events	14	9.61e-01	9.75e-01	0.04530	-0.022500	3.93e-02	8.84e-01	7.99e-01
TRAF3-dependent IRF activation pathway	13	9.64e-01	9.78e-01	0.04470	0.021400	-3.92e-02	8.94e-01	8.07e-01
Condensation of Prometaphase Chromosomes	10	9.65e-01	9.78e-01	0.04980	-0.015500	4.73e-02	9.32e-01	7.96e-01
Deadenylation-dependent mRNA decay	50	9.66e-01	9.78e-01	0.02130	-0.020900	-4.24e-03	7.99e-01	9.59e-01
IRS-related events triggered by IGF1R	22	9.67e-01	9.78e-01	0.03060	0.025200	1.74e-02	8.38e-01	8.88e-01
Inhibition of DNA recombination at telomere	16	9.71e-01	9.82e-01	0.03370	0.014300	3.06e-02	9.21e-01	8.32e-01
FGFR2 alternative splicing	21	9.73e-01	9.83e-01	0.03060	0.017200	-2.52e-02	8.91e-01	8.41e-01
Keratan sulfate biosynthesis	15	9.76e-01	9.84e-01	0.03400	-0.017800	2.90e-02	9.05e-01	8.46e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	15	9.76e-01	9.84e-01	0.03200	-0.007270	-3.12e-02	9.61e-01	8.34e-01
Processing of Capped Intronless Pre-mRNA	21	9.77e-01	9.84e-01	0.02590	-0.016200	-2.02e-02	8.98e-01	8.73e-01
AURKA Activation by TPX2	59	9.82e-01	9.89e-01	0.01370	-0.012500	-5.71e-03	8.69e-01	9.40e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	14	9.89e-01	9.94e-01	0.02340	0.023400	-1.18e-03	8.80e-01	9.94e-01
Regulation of PLK1 Activity at G2/M Transition	74	9.90e-01	9.95e-01	0.00985	-0.004920	8.53e-03	9.42e-01	8.99e-01
Signaling by FGFR2 in disease	23	9.92e-01	9.95e-01	0.01490	-0.000318	1.49e-02	9.98e-01	9.02e-01
Methylation	10	9.94e-01	9.95e-01	0.02020	-0.020200	7.74e-04	9.12e-01	9.97e-01
TP53 Regulates Transcription of Cell Cycle Genes	43	9.94e-01	9.95e-01	0.01010	0.007610	-6.67e-03	9.31e-01	9.40e-01
Metabolism of vitamins and cofactors	107	9.94e-01	9.95e-01	0.00615	0.005680	-2.36e-03	9.19e-01	9.67e-01
Visual phototransduction	31	9.96e-01	9.96e-01	0.00900	-0.003790	-8.16e-03	9.71e-01	9.37e-01

---

Detailed Gene set reports

Neutrophil degranulation

Neutrophil degranulation

metric	value
setSize	306
pMANOVA	1.47e-53
p.adjustMANOVA	1.65e-50
s.dist	0.522
s.RNA	0.52
s.meth	-0.0482
p.RNA	7.52e-55
p.meth	0.151

Top 20 genes

Gene	RNA	meth
CKAP4	4371	-6717
MNDA	4330	-6779
CYFIP1	4286	-6630
CTSZ	4137	-6765
QPCT	4359	-6405
TRPM2	4228	-6600
RAB3D	4269	-6515
TLR2	4180	-6586
PYCARD	3986	-6598
LAMTOR1	4379	-5950
BRI3	4176	-6229
PLD1	4274	-6058
ATP6V0A1	4395	-5877
P2RX1	3818	-6722
ALOX5	4195	-6082
CREG1	4413	-5637
GCA	4399	-5597
C3AR1	3600	-6729
PLAUR	3843	-6237
CAPN1	3912	-6119

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2185	-3533
ACAA1	3791	1410
ACLY	1979	-5417
ACTR10	3334	-1291
ACTR1B	-3763	-3653
ACTR2	3442	-3374
ADAM10	3964	976
ADAM8	2234	-5902
ADGRE5	-743	-5511
AGA	-1312	-2458
AGL	-952	-3188
AGPAT2	4297	2250
ALAD	3905	-1369
ALDOA	4289	-1349
ALDOC	-994	-6226
ALOX5	4195	-6082
AMPD3	4050	-5620
ANO6	3557	-3634
AP1M1	2828	-2408
APAF1	4182	-2104
APEH	342	1724
APRT	-829	-204
ARHGAP9	2546	2156
ARL8A	3739	-6230
ARMC8	2638	-1033
ARPC5	3937	-3837
ARSA	1185	-3099
ARSB	3173	-5722
ASAH1	3775	335
ATAD3B	-3522	-1948
ATG7	3598	569
ATP11A	3806	-5671
ATP11B	2480	1806
ATP6V0A1	4395	-5877
ATP6V0C	4207	-4697
ATP6V1D	4210	-1234
ATP8A1	-4582	-250
ATP8B4	2974	1090
B2M	-2236	-2389
B4GALT1	1562	-160
BIN2	2275	-2805
BRI3	4176	-6229
BST2	-2451	-1970
C3AR1	3600	-6729
C6orf120	2534	1218
CAB39	3774	-2802
CAND1	-2049	-421
CAP1	3678	-553
CAPN1	3912	-6119
CAT	4221	-3922
CCT2	-2968	-727
CCT8	2742	-1245
CD300A	-621	-6466
CD44	3745	266
CD47	-4770	-114
CD53	3514	2243
CD55	4233	-3923
CD58	2760	-3228
CD59	2365	-6024
CD63	4327	-1017
CDK13	-2893	-700
CEACAM1	2970	-5827
CEP290	-3247	-2056
CKAP4	4371	-6717
CMTM6	3436	-3483
CNN2	2792	1735
COMMD3	-436	-6772
COMMD9	3497	-4811
COPB1	3188	-1329
COTL1	3393	2411
CPNE1	-1013	1274
CPNE3	2359	-2088
CPPED1	3723	-3919
CREG1	4413	-5637
CSNK2B	1384	-998
CSTB	2867	-2676
CTSA	4423	-4847
CTSB	4310	-4209
CTSC	817	1561
CTSD	4393	1642
CTSS	3735	-2958
CTSZ	4137	-6765
CYB5R3	4077	-1540
CYBA	2925	1006
CYFIP1	4286	-6630
CYSTM1	4284	-5233
DBNL	3466	-3713
DEGS1	2545	-193
DERA	3816	-756
DGAT1	2058	-6115
DIAPH1	-221	1033
DNAJC13	3648	-4825
DNAJC3	3833	-2353
DNAJC5	3994	-5119
DPP7	-1359	-1037
DSN1	-4082	369
DYNC1H1	-2569	1504
DYNC1LI1	2948	-2912
DYNLL1	2413	-3319
DYNLT1	1624	1458
EEF1A1	-1543	720
EEF2	93	2127
ENPP4	-3460	-1178
ERP44	2824	1942
FABP5	2453	-3534
FAF2	2193	-4965
FGR	3790	-5292
FTH1	1806	-521
FTL	3959	-4621
FUCA1	3251	-5579
FUCA2	3675	-427
GAA	3578	-3801
GALNS	3068	-854
GCA	4399	-5597
GDI2	3151	-587
GGH	2601	-2788
GHDC	1488	-5520
GLB1	3936	1368
GLIPR1	3427	-2351
GM2A	4138	-825
GMFG	3781	-2699
GNS	4312	-571
GOLGA7	1445	-2970
GPI	2523	-2211
GRN	4290	-4414
GSDMD	622	-3378
GSTP1	62	-5415
GUSB	3221	-4967
GYG1	4223	-5541
HEBP2	3839	-1822
HEXB	3996	-5777
HGSNAT	591	2126
HLA-A	-768	-5991
HLA-B	212	1015
HLA-C	331	-25
HLA-H	-1160	-101
HMGB1	-66	-1263
HMOX2	-4584	2130
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSPA1A	3666	-3825
HSPA1B	2667	-513
HVCN1	1800	-217
IDH1	4421	-2333
IGF2R	3116	-5512
ILF2	-608	-3803
IMPDH1	4348	-750
IMPDH2	-3359	446
IQGAP1	3672	1271
IQGAP2	2544	-246
IST1	2352	-3896
ITGAL	-4114	2268
ITGAV	2458	-5201
ITGB2	4091	1322
KCMF1	3522	-3080
KCNAB2	0	-6014
KPNB1	799	-2176
LAIR1	3132	-6275
LAMP1	3308	-376
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LPCAT1	-2464	1540
LRMP	139	24
LTA4H	4306	-972
MAN2B1	2866	-6345
MANBA	3165	1807
MAPK1	3257	1865
MAPK14	4264	-3529
MIF	-1139	-2943
MLEC	742	953
MMP25	3923	1010
MNDA	4330	-6779
MPO	3167	-6776
MVP	3018	-2267
NAPRT	3249	-6164
NBEAL2	3052	-4329
NCKAP1L	3255	-6178
NCSTN	4222	-3821
NDUFC2	2499	-4977
NEU1	4191	-3878
NHLRC3	396	1682
NIT2	-4526	-2140
NME2	582	-4319
NPC2	2105	-712
ORMDL3	-3560	-2716
OSCAR	4225	-4669
OSTF1	3258	1667
P2RX1	3818	-6722
PA2G4	-1179	-175
PAFAH1B2	2967	-1392
PDAP1	2389	-1208
PDXK	3943	-5028
PFKL	-975	-5964
PGAM1	4394	-2347
PGM1	2353	-4799
PGM2	4366	-1959
PKM	4363	-3076
PLAC8	3909	-4418
PLAU	1855	-6512
PLAUR	3843	-6237
PLD1	4274	-6058
PLEKHO2	3639	-3111
PNP	3864	-4436
PPIA	-2188	490
PPIE	-2980	644
PRCP	3691	368
PRDX6	4128	916
PRKCD	4146	584
PRTN3	2850	-6448
PSAP	2899	-4192
PSEN1	3454	-3407
PSMA2	2087	1205
PSMA5	-1904	592
PSMB1	1146	-1179
PSMB7	3871	-2038
PSMC3	637	-4615
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD6	3475	-5488
PSMD7	2396	7
PTGES2	-2149	-1462
PTPN6	2483	-4586
PTPRC	715	-1407
PTPRJ	3447	2365
PTPRN2	1973	2235
PYCARD	3986	-6598
PYGB	151	-5617
QPCT	4359	-6405
QSOX1	4308	-1087
RAB10	4097	-3437
RAB14	3005	1334
RAB18	3484	-1995
RAB24	2077	-3725
RAB27A	3850	-1181
RAB37	-4598	-5384
RAB3A	3705	-1080
RAB3D	4269	-6515
RAB4B	1059	1318
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAC1	3977	971
RAP1A	3142	323
RAP1B	1106	-1031
RAP2B	-214	-2291
RHOA	3688	1313
RHOF	-4868	1911
RHOG	3876	860
RNASET2	2357	2094
ROCK1	3215	-985
S100A11	4142	-1013
S100P	3883	1295
SCAMP1	575	-356
SDCBP	4350	-2535
SERPINB1	4389	-4489
SERPINB6	2273	-5578
SLC11A1	4230	-4413
SLC15A4	1337	-5940
SLC27A2	-1163	-6055
SLC2A3	4226	-4757
SLC44A2	878	2003
SLCO4C1	1162	-1063
SNAP23	3895	-6016
SNAP29	2623	-4157
SPTAN1	-4369	-1250
SRP14	2618	-848
STBD1	2254	-6441
STK10	-1134	-3955
STK11IP	1238	-3840
STOM	2933	-3877
SURF4	3043	1222
SVIP	668	-4596
TBC1D10C	-4450	2261
TCIRG1	3114	-5082
TLR2	4180	-6586
TMBIM1	3803	-1433
TMC6	-3751	2299
TMEM179B	158	276
TMEM30A	3550	-1977
TMEM63A	-2845	-5444
TNFRSF1B	2338	2416
TOLLIP	3944	-5037
TOM1	4217	-5118
TRAPPC1	3480	-3029
TRPM2	4228	-6600
TSPAN14	2956	1366
TUBB	-2260	1395
TUBB4B	3154	1856
TXNDC5	174	-5179
TYROBP	3294	-6720
UNC13D	3353	-6493
VAMP8	2013	-6050
VAPA	4183	-5592
VAT1	4324	-3481
VCL	3178	-5870
VCP	2927	-2411
XRCC5	2099	-3770
XRCC6	-1338	376
YPEL5	2795	-1479

---

---

Innate Immune System

Innate Immune System

metric	value
setSize	617
pMANOVA	2.24e-46
p.adjustMANOVA	1.25e-43
s.dist	0.347
s.RNA	0.346
s.meth	-0.0129
p.RNA	1.52e-47
p.meth	0.593

Top 20 genes

Gene	RNA	meth
CKAP4	4371	-6717
MNDA	4330	-6779
NCF4	4349	-6732
CYFIP1	4286	-6630
CTSZ	4137	-6765
QPCT	4359	-6405
TRPM2	4228	-6600
RAB3D	4269	-6515
TLR2	4180	-6586
PRKACA	4377	-6032
PYCARD	3986	-6598
LAMTOR1	4379	-5950
BRI3	4176	-6229
PLD1	4274	-6058
IRAK3	4111	-6295
ATP6V0A1	4395	-5877
P2RX1	3818	-6722
NLRP3	4033	-6357
ALOX5	4195	-6082
TLR1	4160	-6127

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2185	-3533
AAMP	-1094	-5298
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ACAA1	3791	1410
ACLY	1979	-5417
ACTB	4172	-4515
ACTG1	3946	1793
ACTR10	3334	-1291
ACTR1B	-3763	-3653
ACTR2	3442	-3374
ACTR3	3481	-2917
ADAM10	3964	976
ADAM8	2234	-5902
ADGRE5	-743	-5511
AGA	-1312	-2458
AGL	-952	-3188
AGPAT2	4297	2250
AHCYL1	2655	-3553
AIM2	-510	-3997
ALAD	3905	-1369
ALDOA	4289	-1349
ALDOC	-994	-6226
ALOX5	4195	-6082
AMPD3	4050	-5620
ANO6	3557	-3634
AP1M1	2828	-2408
APAF1	4182	-2104
APEH	342	1724
APP	4212	-5300
APRT	-829	-204
ARHGAP9	2546	2156
ARL8A	3739	-6230
ARMC8	2638	-1033
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ARSA	1185	-3099
ARSB	3173	-5722
ASAH1	3775	335
ATAD3B	-3522	-1948
ATF1	2271	-2565
ATG12	-252	-111
ATG5	444	-2626
ATG7	3598	569
ATOX1	1607	-5343
ATP11A	3806	-5671
ATP11B	2480	1806
ATP6V0A1	4395	-5877
ATP6V0A2	-4820	689
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
ATP8A1	-4582	-250
ATP8B4	2974	1090
B2M	-2236	-2389
B4GALT1	1562	-160
BAIAP2	-56	1977
BCL10	2346	-3261
BCL2	-1339	2361
BCL2L1	4028	1306
BIN2	2275	-2805
BIRC2	1750	-1862
BIRC3	-4025	-2320
BRI3	4176	-6229
BRK1	3002	1970
BST2	-2451	-1970
BTRC	-1491	-2427
C3AR1	3600	-6729
C6orf120	2534	1218
C8G	-4532	397
CAB39	3774	-2802
CALM1	-614	-5019
CAND1	-2049	-421
CAP1	3678	-553
CAPN1	3912	-6119
CAPZA1	3657	572
CAPZA2	3861	-36
CARD11	-4727	851
CARD9	2749	-6197
CASP1	1434	-1448
CASP10	-1033	-6612
CASP4	2388	-5184
CASP8	-4381	387
CASP9	3414	-234
CAT	4221	-3922
CCT2	-2968	-727
CCT8	2742	-1245
CD247	-4870	2098
CD300A	-621	-6466
CD4	-1631	-6372
CD44	3745	266
CD46	2347	-4098
CD47	-4770	-114
CD53	3514	2243
CD55	4233	-3923
CD58	2760	-3228
CD59	2365	-6024
CD63	4327	-1017
CD81	-3273	-4830
CDC34	3982	-2454
CDC42	3265	-2719
CDK13	-2893	-700
CEACAM1	2970	-5827
CEP290	-3247	-2056
CFL1	3703	912
CHUK	3527	1343
CKAP4	4371	-6717
CMTM6	3436	-3483
CNN2	2792	1735
CNPY3	3445	-3161
COMMD3	-436	-6772
COMMD9	3497	-4811
COPB1	3188	-1329
COTL1	3393	2411
CPNE1	-1013	1274
CPNE3	2359	-2088
CPPED1	3723	-3919
CRCP	1826	-577
CREB1	-423	-672
CREBBP	1169	-5804
CREG1	4413	-5637
CRK	4109	-4581
CSNK2B	1384	-998
CSTB	2867	-2676
CTNNB1	2647	-1691
CTSA	4423	-4847
CTSB	4310	-4209
CTSC	817	1561
CTSD	4393	1642
CTSL	1667	-6671
CTSS	3735	-2958
CTSV	-848	-5834
CTSZ	4137	-6765
CUL1	-4385	-5146
CYB5R3	4077	-1540
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
CYLD	-3106	1406
CYSTM1	4284	-5233
DBNL	3466	-3713
DDX41	1170	-118
DDX58	-4687	-1002
DEGS1	2545	-193
DERA	3816	-756
DGAT1	2058	-6115
DHX36	-1604	2251
DHX58	-4639	-5666
DHX9	317	871
DIAPH1	-221	1033
DNAJC13	3648	-4825
DNAJC3	3833	-2353
DNAJC5	3994	-5119
DNM1	1196	-5619
DNM2	2474	738
DPP7	-1359	-1037
DSN1	-4082	369
DTX4	2517	1530
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
DYNC1H1	-2569	1504
DYNC1LI1	2948	-2912
DYNLL1	2413	-3319
DYNLT1	1624	1458
ECSIT	1866	-4938
EEA1	1690	-711
EEF1A1	-1543	720
EEF2	93	2127
ELMO1	2569	-2714
ELMO2	1638	1326
ENPP4	-3460	-1178
EP300	2504	-4509
ERP44	2824	1942
FABP5	2453	-3534
FADD	2255	-6328
FAF2	2193	-4965
FBXW11	2542	-6747
FGR	3790	-5292
FOS	2486	2149
FTH1	1806	-521
FTL	3959	-4621
FUCA1	3251	-5579
FUCA2	3675	-427
FYN	-4569	1957
GAA	3578	-3801
GAB2	3616	-6153
GALNS	3068	-854
GCA	4399	-5597
GDI2	3151	-587
GGH	2601	-2788
GHDC	1488	-5520
GLB1	3936	1368
GLIPR1	3427	-2351
GM2A	4138	-825
GMFG	3781	-2699
GNS	4312	-571
GOLGA7	1445	-2970
GPI	2523	-2211
GRAP2	1747	-5763
GRB2	4321	-2295
GRN	4290	-4414
GSDMD	622	-3378
GSTP1	62	-5415
GUSB	3221	-4967
GYG1	4223	-5541
GZMM	-4599	2516
HEBP2	3839	-1822
HERC5	-4833	-6136
HEXB	3996	-5777
HGSNAT	591	2126
HLA-A	-768	-5991
HLA-B	212	1015
HLA-C	331	-25
HLA-E	-1327	-2213
HLA-H	-1160	-101
HMGB1	-66	-1263
HMOX2	-4584	2130
HRAS	-989	-4780
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSP90B1	655	-1371
HSPA1A	3666	-3825
HSPA1B	2667	-513
HVCN1	1800	-217
ICAM2	-4699	427
ICAM3	3500	2137
IDH1	4421	-2333
IFIH1	-4410	-4856
IGF2R	3116	-5512
IKBKB	-1620	-3894
IKBKE	1764	2086
ILF2	-608	-3803
IMPDH1	4348	-750
IMPDH2	-3359	446
IQGAP1	3672	1271
IQGAP2	2544	-246
IRAK2	-3415	-1457
IRAK3	4111	-6295
IRF3	-2867	542
IRF7	-3037	1622
ISG15	-4761	1894
IST1	2352	-3896
ITCH	429	-1366
ITGAL	-4114	2268
ITGAV	2458	-5201
ITGB2	4091	1322
ITK	-4146	-6507
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JUN	1372	69
KCMF1	3522	-3080
KCNAB2	0	-6014
KPNB1	799	-2176
KRAS	1294	440
LAIR1	3132	-6275
LAMP1	3308	-376
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAT2	4087	-5840
LCK	-4404	2489
LCP2	-357	1588
LGMN	-1423	313
LIMK1	1743	-3787
LPCAT1	-2464	1540
LRMP	139	24
LRRFIP1	2455	-1040
LTA4H	4306	-972
MALT1	-3952	-2968
MAN2B1	2866	-6345
MANBA	3165	1807
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K14	-4394	-2542
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MAVS	3095	-4500
MEF2A	3577	-2822
MIF	-1139	-2943
MLEC	742	953
MMP25	3923	1010
MNDA	4330	-6779
MPO	3167	-6776
MUC1	2718	-5557
MUC12	-4050	-5807
MUC5B	-1387	2353
MVP	3018	-2267
MYD88	3613	-1927
MYH9	2818	2182
MYO9B	2658	687
NAPRT	3249	-6164
NBEAL2	3052	-4329
NCF4	4349	-6732
NCK1	-4400	-1408
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NCSTN	4222	-3821
NDUFC2	2499	-4977
NEU1	4191	-3878
NF2	-2071	-2754
NFATC1	-3230	2372
NFATC2	-4839	2414
NFATC3	-4786	92
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NHLRC3	396	1682
NIT2	-4526	-2140
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NLRC5	-3653	1646
NLRP1	-1838	-5049
NLRP3	4033	-6357
NLRX1	3474	-2858
NME2	582	-4319
NOD1	-4838	-5170
NOD2	3786	1528
NOS3	-515	-1770
NPC2	2105	-712
ORMDL3	-3560	-2716
OSCAR	4225	-4669
OSTF1	3258	1667
P2RX1	3818	-6722
PA2G4	-1179	-175
PAFAH1B2	2967	-1392
PAK1	3707	-3995
PAK2	3694	-3961
PANX1	2493	1595
PCBP2	2042	132
PDAP1	2389	-1208
PDPK1	2505	167
PDXK	3943	-5028
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PFKL	-975	-5964
PGAM1	4394	-2347
PGM1	2353	-4799
PGM2	4366	-1959
PIK3CA	1725	-1445
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R4	-1199	-3425
PIN1	-972	-1656
PKM	4363	-3076
PLA2G6	-4717	-3132
PLAC8	3909	-4418
PLAU	1855	-6512
PLAUR	3843	-6237
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLD1	4274	-6058
PLD3	3212	1541
PLEKHO2	3639	-3111
PNP	3864	-4436
POLR1C	-3778	-2688
POLR1D	2750	-2500
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2H	-849	1944
POLR2K	-536	-2424
POLR3A	-2377	2213
POLR3C	-2457	509
POLR3D	-4442	1264
POLR3E	-4160	-673
POLR3F	-1600	-5523
POLR3G	-1657	1201
POLR3GL	-2491	-6348
POLR3H	-3707	-510
POLR3K	-756	1383
PPIA	-2188	490
PPIE	-2980	644
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PPP3CA	2571	-2165
PPP3CB	2950	517
PPP3R1	3702	-3276
PRCP	3691	368
PRDX6	4128	916
PRKACA	4377	-6032
PRKACB	-4623	455
PRKCD	4146	584
PRKCE	-2656	-5632
PRKCQ	-4731	1372
PRKCSH	2022	-3007
PRKDC	-3663	1316
PRTN3	2850	-6448
PSAP	2899	-4192
PSEN1	3454	-3407
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PSTPIP1	3510	1135
PTGES2	-2149	-1462
PTK2	1637	920
PTPN11	2065	-2302
PTPN4	-4781	-3156
PTPN6	2483	-4586
PTPRC	715	-1407
PTPRJ	3447	2365
PTPRN2	1973	2235
PYCARD	3986	-6598
PYGB	151	-5617
QPCT	4359	-6405
QSOX1	4308	-1087
RAB10	4097	-3437
RAB14	3005	1334
RAB18	3484	-1995
RAB24	2077	-3725
RAB27A	3850	-1181
RAB37	-4598	-5384
RAB3A	3705	-1080
RAB3D	4269	-6515
RAB4B	1059	1318
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAC1	3977	971
RAC2	1994	-868
RAF1	3548	-314
RAP1A	3142	323
RAP1B	1106	-1031
RAP2B	-214	-2291
RASGRP1	-4601	2119
RASGRP2	-2706	1508
RBSN	-1371	-2813
RELA	-541	2085
RELB	1295	-5206
RHOA	3688	1313
RHOF	-4868	1911
RHOG	3876	860
RIPK3	1514	-370
RNASET2	2357	2094
RNF125	-4303	-1762
RNF135	3870	-6458
RNF216	-3753	201
ROCK1	3215	-985
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
S100A11	4142	-1013
S100P	3883	1295
SARM1	-4686	-5412
SCAMP1	575	-356
SDCBP	4350	-2535
SERPINB1	4389	-4489
SERPINB6	2273	-5578
SHC1	1469	-2954
SIGIRR	-3945	290
SIKE1	-2218	-1187
SKP1	1561	-2290
SLC11A1	4230	-4413
SLC15A4	1337	-5940
SLC27A2	-1163	-6055
SLC2A3	4226	-4757
SLC44A2	878	2003
SLCO4C1	1162	-1063
SNAP23	3895	-6016
SNAP29	2623	-4157
SOCS1	1346	-2999
SOS1	-1758	-6775
SPTAN1	-4369	-1250
SRC	-3100	-4427
SRP14	2618	-848
STAT6	2355	-3911
STBD1	2254	-6441
STK10	-1134	-3955
STK11IP	1238	-3840
STOM	2933	-3877
SUGT1	483	594
SURF4	3043	1222
SVIP	668	-4596
SYK	4194	-5054
TAB2	2991	1892
TANK	3243	-1331
TAX1BP1	2377	-4470
TBC1D10C	-4450	2261
TBK1	1029	-4616
TCIRG1	3114	-5082
TEC	3241	-5839
TICAM1	2598	-2136
TIFA	1838	-1726
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR3	-4429	-5820
TLR5	4278	1823
TLR6	4103	-802
TLR9	-1815	2292
TMBIM1	3803	-1433
TMC6	-3751	2299
TMEM179B	158	276
TMEM30A	3550	-1977
TMEM63A	-2845	-5444
TNFAIP3	-4190	-785
TNFRSF1B	2338	2416
TNIP2	2191	-5726
TOLLIP	3944	-5037
TOM1	4217	-5118
TRAF2	-4465	-1442
TRAF3	-1622	2379
TRAF6	-81	-6118
TRAPPC1	3480	-3029
TREX1	-378	-5868
TRIM21	786	-6370
TRIM25	3724	-3718
TRIM56	-3041	141
TRPM2	4228	-6600
TSPAN14	2956	1366
TUBB	-2260	1395
TUBB4B	3154	1856
TXK	-4571	170
TXN	3798	284
TXNDC5	174	-5179
TXNIP	-3453	-2777
TYROBP	3294	-6720
UBA3	3408	-2122
UBA52	344	752
UBA7	-2412	-6667
UBB	2801	-1321
UBC	1599	-2568
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2K	2853	1379
UBE2L6	-4358	-4206
UBE2M	3295	-3585
UBE2N	616	1127
UBE2V1	2217	-1021
UNC13D	3353	-6493
UNC93B1	1454	-4358
VAMP8	2013	-6050
VAPA	4183	-5592
VAT1	4324	-3481
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCL	3178	-5870
VCP	2927	-2411
VRK3	402	-1398
VTN	-615	2265
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WIPF1	182	-4382
WIPF2	2264	-2523
XRCC5	2099	-3770
XRCC6	-1338	376
YES1	-4790	-4415
YPEL5	2795	-1479
ZBP1	-4859	-410

---

---

Immune System

Immune System

metric	value
setSize	1197
pMANOVA	1.78e-29
p.adjustMANOVA	6.65e-27
s.dist	0.2
s.RNA	0.194
s.meth	0.0494
p.RNA	1.21e-27
p.meth	0.00571

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
AGPAT2	4297	2250
SOCS3	4414	2178
SIAH2	3939	2185
COTL1	3393	2411
PTPRJ	3447	2365
CD53	3514	2243
TLR5	4278	1823
LCP1	3800	2024
ICAM3	3500	2137
EIF4E3	3351	2181
IL19	2870	2517
CTSD	4393	1642
ACTG1	3946	1793
RNF123	2894	2363
ATP6V1A	4307	1580
ATP6V0B	3961	1604
LAMTOR2	3365	1882
MYH9	2818	2182
PPP2CB	3404	1797

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2185	-3533
AAAS	-2797	405
AAMP	-1094	-5298
ABCE1	-3903	-1384
ABHD17A	-3997	902
ABHD17B	-13	-1287
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ACAA1	3791	1410
ACLY	1979	-5417
ACTB	4172	-4515
ACTG1	3946	1793
ACTR10	3334	-1291
ACTR1A	3003	-1
ACTR1B	-3763	-3653
ACTR2	3442	-3374
ACTR3	3481	-2917
ADAM10	3964	976
ADAM17	3540	774
ADAM8	2234	-5902
ADAR	-1039	-263
ADGRE5	-743	-5511
AGA	-1312	-2458
AGL	-952	-3188
AGPAT2	4297	2250
AHCYL1	2655	-3553
AIM2	-510	-3997
AIP	-1079	1761
AKT1	1248	-1942
AKT2	108	-141
ALAD	3905	-1369
ALDOA	4289	-1349
ALDOC	-994	-6226
ALOX5	4195	-6082
AMPD3	4050	-5620
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC13	940	-1507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
ANO6	3557	-3634
AP1B1	3990	-463
AP1G1	1421	516
AP1M1	2828	-2408
AP1S3	-1711	-5455
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
APAF1	4182	-2104
APBB1IP	4055	-5120
APEH	342	1724
APP	4212	-5300
APRT	-829	-204
AREL1	2707	-139
ARF1	4190	-6686
ARHGAP9	2546	2156
ARIH1	-682	-323
ARIH2	-4755	846
ARL2	-203	-4526
ARL8A	3739	-6230
ARMC8	2638	-1033
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ARRB1	659	-6363
ARRB2	3858	-2243
ARSA	1185	-3099
ARSB	3173	-5722
ASAH1	3775	335
ASB1	1098	1900
ASB13	1125	-5265
ASB2	-4713	-2230
ASB6	-835	-6098
ASB7	2567	-4653
ASB8	1852	998
ATAD3B	-3522	-1948
ATF1	2271	-2565
ATG12	-252	-111
ATG5	444	-2626
ATG7	3598	569
ATOX1	1607	-5343
ATP11A	3806	-5671
ATP11B	2480	1806
ATP6V0A1	4395	-5877
ATP6V0A2	-4820	689
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
ATP8A1	-4582	-250
ATP8B4	2974	1090
B2M	-2236	-2389
B4GALT1	1562	-160
BAIAP2	-56	1977
BATF	2672	2070
BCL10	2346	-3261
BCL2	-1339	2361
BCL2L1	4028	1306
BCL6	4305	-299
BIN2	2275	-2805
BIRC2	1750	-1862
BIRC3	-4025	-2320
BIRC5	1432	-84
BLMH	991	-515
BRAF	406	-4347
BRAP	2050	-3662
BRI3	4176	-6229
BRK1	3002	1970
BRWD1	-3181	-3884
BST2	-2451	-1970
BTBD1	718	-5321
BTBD6	-1611	-136
BTN2A1	-2772	-107
BTN2A2	-4457	-893
BTN3A1	-4874	1435
BTN3A2	-4547	599
BTN3A3	-4840	2244
BTRC	-1491	-2427
C3AR1	3600	-6729
C6orf120	2534	1218
C8G	-4532	397
CAB39	3774	-2802
CALM1	-614	-5019
CALR	2620	-3753
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAND1	-2049	-421
CANX	2138	-4839
CAP1	3678	-553
CAPN1	3912	-6119
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CARD11	-4727	851
CARD9	2749	-6197
CASP1	1434	-1448
CASP10	-1033	-6612
CASP3	-160	-2764
CASP4	2388	-5184
CASP8	-4381	387
CASP9	3414	-234
CAT	4221	-3922
CBL	3300	1456
CBLB	-4854	-840
CCND1	-2169	-6213
CCNF	-3306	-4258
CCR1	4062	-6480
CCT2	-2968	-727
CCT8	2742	-1245
CD247	-4870	2098
CD274	-2151	-296
CD300A	-621	-6466
CD3D	-4167	2493
CD3E	-4129	2442
CD4	-1631	-6372
CD44	3745	266
CD46	2347	-4098
CD47	-4770	-114
CD53	3514	2243
CD55	4233	-3923
CD58	2760	-3228
CD59	2365	-6024
CD63	4327	-1017
CD74	-4409	-4283
CD79B	-2318	-6685
CD81	-3273	-4830
CD96	-4698	2283
CDC16	-1863	-4152
CDC20	1435	116
CDC23	-4319	-707
CDC34	3982	-2454
CDC42	3265	-2719
CDK13	-2893	-700
CDKN1A	1606	-3540
CEACAM1	2970	-5827
CEBPD	4041	-5142
CENPE	232	-4165
CEP290	-3247	-2056
CFL1	3703	912
CHUK	3527	1343
CISH	1861	1748
CKAP4	4371	-6717
CLEC2B	-3126	-4871
CLTA	3793	-5077
CLTC	4170	2477
CMTM6	3436	-3483
CNN2	2792	1735
CNPY3	3445	-3161
COMMD3	-436	-6772
COMMD9	3497	-4811
COPB1	3188	-1329
COTL1	3393	2411
CPNE1	-1013	1274
CPNE3	2359	-2088
CPPED1	3723	-3919
CRCP	1826	-577
CREB1	-423	-672
CREBBP	1169	-5804
CREG1	4413	-5637
CRK	4109	-4581
CRKL	1383	-906
CSF1	-605	-5924
CSK	2014	862
CSNK2B	1384	-998
CSTB	2867	-2676
CTF1	1575	-5738
CTLA4	-3873	2506
CTNNB1	2647	-1691
CTSA	4423	-4847
CTSB	4310	-4209
CTSC	817	1561
CTSD	4393	1642
CTSL	1667	-6671
CTSO	-4406	1113
CTSS	3735	-2958
CTSV	-848	-5834
CTSZ	4137	-6765
CUL1	-4385	-5146
CUL2	821	-1212
CUL3	2907	2054
CUL5	269	-3077
CUL7	-1000	-2524
CXCL2	2131	-6755
CYB5R3	4077	-1540
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
CYLD	-3106	1406
CYSTM1	4284	-5233
DAPP1	2070	279
DBNL	3466	-3713
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DDX41	1170	-118
DDX58	-4687	-1002
DEGS1	2545	-193
DERA	3816	-756
DET1	-3125	978
DGAT1	2058	-6115
DHX36	-1604	2251
DHX58	-4639	-5666
DHX9	317	871
DIAPH1	-221	1033
DLG1	-2798	-3985
DLG2	-1714	1854
DLG4	4181	-3021
DNAJC13	3648	-4825
DNAJC3	3833	-2353
DNAJC5	3994	-5119
DNM1	1196	-5619
DNM2	2474	738
DPP7	-1359	-1037
DSN1	-4082	369
DTX4	2517	1530
DUSP1	2979	238
DUSP10	-486	-1469
DUSP16	-2084	-2622
DUSP2	-3348	616
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP5	-4824	1801
DUSP6	1572	-6763
DUSP7	-965	-1322
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
DYNLT1	1624	1458
DZIP3	-4018	-5113
ECSIT	1866	-4938
EDARADD	-4121	1906
EEA1	1690	-711
EEF1A1	-1543	720
EEF2	93	2127
EGR1	955	-163
EIF2AK2	-3267	-3645
EIF4A1	3272	-3762
EIF4A2	-4065	836
EIF4A3	3171	-3850
EIF4E	1815	1536
EIF4E2	3194	1473
EIF4E3	3351	2181
EIF4G1	3607	746
EIF4G2	2951	-3101
EIF4G3	3826	-3868
ELMO1	2569	-2714
ELMO2	1638	1326
ENPP4	-3460	-1178
EP300	2504	-4509
ERAP1	-2324	-1887
ERAP2	-1613	-1261
ERBB2	-4860	-5145
ERP44	2824	1942
EVL	-4735	2303
FABP5	2453	-3534
FADD	2255	-6328
FAF2	2193	-4965
FBXL12	-400	292
FBXL14	-1870	2358
FBXL15	1650	-4502
FBXL16	-2110	-4011
FBXL18	1128	-5248
FBXL19	3985	-6239
FBXL20	1825	-993
FBXL22	-3236	562
FBXL3	329	-4101
FBXL4	2160	-5130
FBXL5	4384	-6189
FBXL8	1405	-479
FBXO11	2807	-500
FBXO15	-347	647
FBXO21	-4031	-933
FBXO22	-1110	1132
FBXO30	1752	-609
FBXO31	-4648	480
FBXO32	-4006	-1875
FBXO4	-4627	-4056
FBXO6	-687	234
FBXO7	3287	-3059
FBXO9	4390	-3674
FBXW11	2542	-6747
FBXW2	2739	-3711
FBXW4	-4464	1993
FBXW5	75	-194
FBXW7	-2109	-5428
FBXW8	-3566	-2504
FGF9	-3030	1634
FGR	3790	-5292
FKBP1A	4177	-4465
FLNB	547	1550
FLT3LG	-3269	1573
FNTA	-1750	1499
FNTB	2466	-4949
FOS	2486	2149
FOXO1	-3171	-5036
FOXO3	3983	711
FRS2	-1016	-1999
FRS3	3191	-2329
FTH1	1806	-521
FTL	3959	-4621
FUCA1	3251	-5579
FUCA2	3675	-427
FYN	-4569	1957
FZR1	-666	-758
GAA	3578	-3801
GAB2	3616	-6153
GALNS	3068	-854
GAN	-427	-2479
GATA3	-4787	1861
GBP3	-2752	-3362
GCA	4399	-5597
GDI2	3151	-587
GGH	2601	-2788
GHDC	1488	-5520
GLB1	3936	1368
GLIPR1	3427	-2351
GLMN	-4233	2117
GM2A	4138	-825
GMFG	3781	-2699
GNS	4312	-571
GOLGA7	1445	-2970
GPI	2523	-2211
GRAP2	1747	-5763
GRB2	4321	-2295
GRIN2D	2300	-4745
GRN	4290	-4414
GSDMD	622	-3378
GSTO1	4196	-170
GSTP1	62	-5415
GUSB	3221	-4967
GYG1	4223	-5541
GZMM	-4599	2516
HACE1	-1804	-6052
HBEGF	1808	-6428
HCST	-1591	1737
HEBP2	3839	-1822
HECTD1	-745	-2953
HECTD3	392	-6086
HERC1	-3248	-1142
HERC3	328	-2583
HERC4	1848	-2430
HERC5	-4833	-6136
HEXB	3996	-5777
HGSNAT	591	2126
HIF1A	3192	-3349
HLA-A	-768	-5991
HLA-B	212	1015
HLA-C	331	-25
HLA-DMA	-3501	-6628
HLA-E	-1327	-2213
HLA-F	-3994	1671
HLA-H	-1160	-101
HMGB1	-66	-1263
HMOX2	-4584	2130
HNRNPA2B1	1139	-2665
HNRNPF	1377	-58
HRAS	-989	-4780
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSP90B1	655	-1371
HSPA1A	3666	-3825
HSPA1B	2667	-513
HSPA9	-3551	-200
HVCN1	1800	-217
ICAM1	2834	-5333
ICAM2	-4699	427
ICAM3	3500	2137
ICAM5	3579	-5930
ICMT	-247	-71
ICOSLG	-1914	-4532
IDH1	4421	-2333
IFI30	3253	-6228
IFI35	-1782	-1569
IFI6	-4673	-2830
IFIH1	-4410	-4856
IFIT1	-4871	-4377
IFIT2	-4797	-5574
IFIT3	-4775	-2035
IFIT5	-4365	-90
IFITM1	-1912	2403
IFNAR1	3863	-490
IFNAR2	2821	-3573
IFNGR1	4280	310
IFNGR2	4303	-6331
IGF2R	3116	-5512
IKBKB	-1620	-3894
IKBKE	1764	2086
IL10RA	-3987	1263
IL10RB	4247	-6138
IL12A	-2392	-5748
IL12RB1	-4763	-1444
IL12RB2	-4720	-5603
IL15	-1627	-5098
IL15RA	829	-3679
IL16	-3204	656
IL17C	-2092	-1115
IL17RA	4276	-3604
IL17RC	56	-1157
IL18BP	-3970	-5936
IL18R1	1550	475
IL19	2870	2517
IL1RAP	3160	-456
IL21R	-4811	401
IL23A	-3468	-6478
IL27RA	1175	-1230
IL2RA	-2353	-6462
IL2RB	-4875	2472
IL32	-3423	2512
IL4R	3205	-4452
IL6R	3697	-6410
IL6ST	1389	1094
ILF2	-608	-3803
IMPDH1	4348	-750
IMPDH2	-3359	446
INPP5D	-1183	-3735
INPPL1	4209	-2224
IP6K2	-3705	-878
IQGAP1	3672	1271
IQGAP2	2544	-246
IRAK2	-3415	-1457
IRAK3	4111	-6295
IRF1	-2898	1887
IRF2	2676	-2044
IRF3	-2867	542
IRF4	-3077	1782
IRF5	2642	-6572
IRF7	-3037	1622
IRF9	-4251	-4118
IRS1	563	-4060
IRS2	3752	-5410
ISG15	-4761	1894
ISG20	-4539	2340
IST1	2352	-3896
ITCH	429	-1366
ITGA4	-4108	1419
ITGAL	-4114	2268
ITGAV	2458	-5201
ITGB2	4091	1322
ITGB7	-4740	-6402
ITK	-4146	-6507
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JAK1	-4154	-1022
JAK2	834	-1751
JUN	1372	69
JUNB	2887	-3031
KBTBD6	-1069	327
KBTBD7	2705	-1326
KBTBD8	-1256	-4094
KCMF1	3522	-3080
KCNAB2	0	-6014
KCTD6	1605	886
KCTD7	-4104	-602
KEAP1	1872	-2872
KIF11	306	-4751
KIF15	-963	-563
KIF18A	-818	-2125
KIF20A	1956	-231
KIF22	-4864	-1801
KIF23	2168	-3340
KIF2A	-332	1788
KIF2C	262	-1625
KIF3A	-4676	-2118
KIF3B	1297	-2584
KIF3C	3823	-5135
KIF5B	3643	-3520
KIFAP3	-2987	1836
KLC1	2174	-1283
KLC2	-2966	-5681
KLC4	-2743	-4132
KLHL11	-1896	186
KLHL2	4277	-4276
KLHL20	-4411	-2781
KLHL21	1908	-1243
KLHL22	-4140	-899
KLHL25	-3758	-464
KLHL5	1950	-4208
KPNA1	409	-2889
KPNA2	-2167	-874
KPNA3	308	-897
KPNA4	1912	1716
KPNA5	-4625	-572
KPNB1	799	-2176
KRAS	1294	440
KSR1	1447	2466
LAIR1	3132	-6275
LAMP1	3308	-376
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAT2	4087	-5840
LCK	-4404	2489
LCP1	3800	2024
LCP2	-357	1588
LGALS9	924	-6589
LGMN	-1423	313
LIMK1	1743	-3787
LMNB1	4362	-942
LMO7	-3257	2419
LNPEP	-3482	-478
LONRF1	1677	-187
LPCAT1	-2464	1540
LRMP	139	24
LRR1	-2547	1362
LRRC41	3306	404
LRRFIP1	2455	-1040
LRSAM1	1818	-530
LTA	-3141	2525
LTA4H	4306	-972
LTB	-2431	1685
LTN1	-763	2476
LYPLA1	3582	184
MALT1	-3952	-2968
MAN2B1	2866	-6345
MANBA	3165	1807
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K11	3368	-2732
MAP3K14	-4394	-2542
MAP3K3	3766	64
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAP1	1937	1057
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MARK3	4010	-3461
MAVS	3095	-4500
MEF2A	3577	-2822
MEX3C	-4766	-2068
MGRN1	2262	-6360
MICA	-1586	-2075
MICB	762	922
MIF	-1139	-2943
MKRN1	4066	-2133
MLEC	742	953
MLST8	98	287
MMP25	3923	1010
MNDA	4330	-6779
MPO	3167	-6776
MRC2	-29	-6280
MT2A	-2299	1556
MTAP	-1778	-5878
MTOR	-3531	-1813
MUC1	2718	-5557
MUC12	-4050	-5807
MUC5B	-1387	2353
MVP	3018	-2267
MX1	-4805	-5375
MX2	-1810	-1978
MYD88	3613	-1927
MYH9	2818	2182
MYLIP	-1189	-681
MYO9B	2658	687
NAPRT	3249	-6164
NBEAL2	3052	-4329
NCF4	4349	-6732
NCK1	-4400	-1408
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NCSTN	4222	-3821
NDC1	-4771	-5228
NDUFC2	2499	-4977
NEDD4	2574	-5611
NEDD4L	3534	-5066
NEU1	4191	-3878
NF1	1012	-2145
NF2	-2071	-2754
NFATC1	-3230	2372
NFATC2	-4839	2414
NFATC3	-4786	92
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NFKBIE	-1625	1607
NHLRC3	396	1682
NIT2	-4526	-2140
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NLRC5	-3653	1646
NLRP1	-1838	-5049
NLRP3	4033	-6357
NLRX1	3474	-2858
NME2	582	-4319
NOD1	-4838	-5170
NOD2	3786	1528
NOS3	-515	-1770
NPC2	2105	-712
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
OAS1	-3452	-5215
OAS2	-4796	2093
OAS3	-4834	-5833
OASL	-4141	-2933
ORAI1	-2313	-4764
ORAI2	2440	-4356
ORMDL3	-3560	-2716
OSCAR	4225	-4669
OSM	3463	-3652
OSTF1	3258	1667
P2RX1	3818	-6722
P4HB	3824	-1549
PA2G4	-1179	-175
PAFAH1B2	2967	-1392
PAG1	1436	262
PAK1	3707	-3995
PAK2	3694	-3961
PANX1	2493	1595
PAQR3	-1174	-6242
PCBP2	2042	132
PDAP1	2389	-1208
PDCD4	-4581	1941
PDE12	-1984	1354
PDE3B	-4305	-4025
PDE6D	2036	-115
PDIA3	1468	1466
PDPK1	2505	167
PDXK	3943	-5028
PEA15	-2211	1280
PEBP1	-4273	-152
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PFKL	-975	-5964
PGAM1	4394	-2347
PGM1	2353	-4799
PGM2	4366	-1959
PHB	-914	-3178
PIAS1	3206	-2534
PIK3AP1	3450	-4753
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R4	-1199	-3425
PILRB	-4177	19
PIM1	3428	-5227
PIN1	-972	-1656
PITPNA	2872	-2752
PJA2	3264	662
PKM	4363	-3076
PLA2G6	-4717	-3132
PLAC8	3909	-4418
PLAU	1855	-6512
PLAUR	3843	-6237
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLD1	4274	-6058
PLD3	3212	1541
PLEKHO2	3639	-3111
PML	-3036	549
PNP	3864	-4436
POLR1C	-3778	-2688
POLR1D	2750	-2500
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2H	-849	1944
POLR2K	-536	-2424
POLR3A	-2377	2213
POLR3C	-2457	509
POLR3D	-4442	1264
POLR3E	-4160	-673
POLR3F	-1600	-5523
POLR3G	-1657	1201
POLR3GL	-2491	-6348
POLR3H	-3707	-510
POLR3K	-756	1383
POM121	-2762	-1787
POM121C	-2356	-4315
POU2F1	497	733
PPIA	-2188	490
PPIE	-2980	644
PPM1B	2222	1592
PPP1CB	3008	1839
PPP1CC	2576	-754
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5A	2378	381
PPP2R5B	2877	-6343
PPP2R5C	-4356	2376
PPP2R5D	777	-4349
PPP2R5E	-200	-2288
PPP3CA	2571	-2165
PPP3CB	2950	517
PPP3R1	3702	-3276
PPP5C	-2478	-41
PRCP	3691	368
PRDX6	4128	916
PRKACA	4377	-6032
PRKACB	-4623	455
PRKCB	2983	-4518
PRKCD	4146	584
PRKCE	-2656	-5632
PRKCQ	-4731	1372
PRKCSH	2022	-3007
PRKDC	-3663	1316
PRR5	-4670	-1591
PRTN3	2850	-6448
PSAP	2899	-4192
PSEN1	3454	-3407
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PSTPIP1	3510	1135
PTEN	3857	-1100
PTGES2	-2149	-1462
PTK2	1637	920
PTK2B	3561	40
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN12	3633	-1077
PTPN13	-3647	-6489
PTPN18	2351	693
PTPN2	3324	-3701
PTPN22	-342	-1114
PTPN23	-369	-3227
PTPN4	-4781	-3156
PTPN6	2483	-4586
PTPN7	-4117	-1888
PTPN9	2738	-1265
PTPRA	-1354	1436
PTPRC	715	-1407
PTPRJ	3447	2365
PTPRN2	1973	2235
PYCARD	3986	-6598
PYGB	151	-5617
QPCT	4359	-6405
QSOX1	4308	-1087
RAB10	4097	-3437
RAB14	3005	1334
RAB18	3484	-1995
RAB24	2077	-3725
RAB27A	3850	-1181
RAB37	-4598	-5384
RAB3A	3705	-1080
RAB3D	4269	-6515
RAB4B	1059	1318
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAC1	3977	971
RAC2	1994	-868
RACGAP1	937	1472
RAE1	1948	-39
RAF1	3548	-314
RALA	865	-262
RALGDS	-4773	1254
RANBP2	-259	-4704
RANBP9	2336	-1361
RAP1A	3142	323
RAP1B	1106	-1031
RAP2B	-214	-2291
RAPGEF1	-3584	1868
RASA1	674	-167
RASA2	-1301	1142
RASA3	-4564	205
RASAL1	-251	-3249
RASAL3	-4634	-4378
RASGRP1	-4601	2119
RASGRP2	-2706	1508
RASGRP3	-3054	-2004
RBBP6	-349	-2825
RBCK1	707	-1357
RBSN	-1371	-2813
RBX1	1413	-3241
RCE1	-1411	-282
RCHY1	2660	2124
REL	1220	-3846
RELA	-541	2085
RELB	1295	-5206
RGL1	3304	1731
RGL2	3270	-1001
RHOA	3688	1313
RHOF	-4868	1911
RHOG	3876	860
RICTOR	-3355	1651
RILP	3815	-4831
RIPK3	1514	-370
RNASEL	3458	326
RNASET2	2357	2094
RNF111	2287	779
RNF114	968	-3694
RNF115	-3434	1631
RNF123	2894	2363
RNF125	-4303	-1762
RNF126	-3955	1899
RNF135	3870	-6458
RNF138	1588	1102
RNF14	1583	-1169
RNF144B	3371	-5953
RNF19A	-3771	1813
RNF19B	2868	380
RNF213	-4661	2228
RNF216	-3753	201
RNF220	-1979	1733
RNF25	-2383	-1189
RNF34	-1908	42
RNF4	-4452	-151
RNF41	3835	109
RNF6	1385	-2084
RNF7	3537	-1943
ROCK1	3215	-985
RORA	-4632	2287
RPLP0	-325	-185
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
S100A11	4142	-1013
S100P	3883	1295
S1PR1	-3197	2436
SAMHD1	2635	-2016
SAR1B	2704	489
SARM1	-4686	-5412
SCAMP1	575	-356
SDCBP	4350	-2535
SEC13	2286	-3749
SEC23A	3198	-5141
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SEC61A1	2678	-592
SEC61A2	-4045	917
SEC61B	3029	33
SEC61G	1795	1052
SEH1L	-1833	-1615
SERPINB1	4389	-4489
SERPINB6	2273	-5578
SH2B1	-2800	-1068
SHC1	1469	-2954
SHOC2	3168	-3532
SIAH1	-897	-6217
SIAH2	3939	2185
SIGIRR	-3945	290
SIKE1	-2218	-1187
SIPA1	1402	-2006
SKP1	1561	-2290
SKP2	-2780	-1566
SLAMF6	-4795	2420
SLC11A1	4230	-4413
SLC15A4	1337	-5940
SLC27A2	-1163	-6055
SLC2A3	4226	-4757
SLC44A2	878	2003
SLCO4C1	1162	-1063
SMAD3	-4431	-4628
SMARCA4	1769	2317
SMURF1	-771	1321
SMURF2	-3700	-3048
SNAP23	3895	-6016
SNAP29	2623	-4157
SNRPA1	-3646	-3336
SOCS1	1346	-2999
SOCS2	-769	378
SOCS3	4414	2178
SOCS5	1047	-4583
SOD1	-1490	-1019
SOD2	1617	573
SOS1	-1758	-6775
SOS2	3767	-4105
SP100	1527	-769
SPRED1	-2940	-6227
SPRED2	2902	521
SPRED3	-2225	-4087
SPSB1	772	-3865
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SQSTM1	1450	-952
SRC	-3100	-4427
SRP14	2618	-848
STAT1	-4575	2195
STAT2	-4052	-3295
STAT3	3649	-3606
STAT4	-4853	-425
STAT5A	2944	-6427
STAT5B	2958	-3446
STAT6	2355	-3911
STBD1	2254	-6441
STIM1	1396	2500
STK10	-1134	-3955
STK11IP	1238	-3840
STOM	2933	-3877
STUB1	-337	-2168
STX1A	-1208	-2461
STX3	3897	-1755
STX4	200	-6001
STXBP2	4178	-6352
SUGT1	483	594
SUMO1	2937	-3986
SURF4	3043	1222
SVIP	668	-4596
SYK	4194	-5054
SYNGAP1	-2974	-2744
TAB2	2991	1892
TALDO1	4405	-5245
TANK	3243	-1331
TAP1	-3969	-4218
TAP2	-4608	1506
TAPBP	993	-1360
TAX1BP1	2377	-4470
TBC1D10C	-4450	2261
TBK1	1029	-4616
TCIRG1	3114	-5082
TCP1	1261	2168
TEC	3241	-5839
TGFA	4154	-3020
TGFB1	1971	-6
THEM4	-4101	-6129
THOP1	-3243	-3580
TICAM1	2598	-2136
TIFA	1838	-1726
TIRAP	2227	-5182
TLN1	3884	191
TLR1	4160	-6127
TLR2	4180	-6586
TLR3	-4429	-5820
TLR5	4278	1823
TLR6	4103	-802
TLR9	-1815	2292
TMBIM1	3803	-1433
TMC6	-3751	2299
TMEM179B	158	276
TMEM30A	3550	-1977
TMEM63A	-2845	-5444
TNF	-2330	-3779
TNFAIP3	-4190	-785
TNFRSF12A	2971	-994
TNFRSF1A	4337	-4958
TNFRSF1B	2338	2416
TNFRSF25	-3422	2275
TNFSF13	3753	-5904
TNFSF13B	2931	-6033
TNFSF14	736	2460
TNFSF9	-1930	1627
TNIP2	2191	-5726
TOLLIP	3944	-5037
TOM1	4217	-5118
TP53	-4078	-739
TPP2	-2978	-1752
TPR	-2272	-973
TRAF2	-4465	-1442
TRAF3	-1622	2379
TRAF6	-81	-6118
TRAF7	3940	-4769
TRAIP	-4386	-3435
TRAPPC1	3480	-3029
TREML2	2646	-6721
TREX1	-378	-5868
TRIB3	-1812	1669
TRIM11	-1103	586
TRIM14	-2136	-1735
TRIM2	-1336	-4681
TRIM21	786	-6370
TRIM22	-4151	-2766
TRIM25	3724	-3718
TRIM26	-3199	-2905
TRIM35	-3506	-31
TRIM36	-2122	-5030
TRIM37	-2589	-3006
TRIM38	781	-931
TRIM39	-3810	-3317
TRIM4	648	1988
TRIM41	774	-1538
TRIM45	-2551	-5568
TRIM46	-2505	-1262
TRIM5	-2274	-3945
TRIM56	-3041	141
TRIM62	-4007	-6401
TRIM68	-4682	1800
TRIM8	3813	1000
TRIM9	647	-726
TRIP12	2940	-3017
TRPC1	-3275	-2704
TRPM2	4228	-6600
TSPAN14	2956	1366
TUBB	-2260	1395
TUBB4B	3154	1856
TXK	-4571	170
TXLNA	-551	-78
TXN	3798	284
TXNDC5	174	-5179
TXNIP	-3453	-2777
TYK2	3075	-3105
TYROBP	3294	-6720
UBA3	3408	-2122
UBA5	-2734	-4241
UBA52	344	752
UBA6	1181	1251
UBA7	-2412	-6667
UBAC1	3736	-4908
UBB	2801	-1321
UBC	1599	-2568
UBE2B	3032	-2486
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2D4	-4326	-3494
UBE2E1	2865	-5882
UBE2E2	556	-6256
UBE2E3	1918	-5759
UBE2F	3224	-3774
UBE2G1	1879	-1626
UBE2G2	-2597	-3560
UBE2H	3435	-1867
UBE2J1	4288	-591
UBE2J2	3785	-368
UBE2K	2853	1379
UBE2L3	3307	-3496
UBE2L6	-4358	-4206
UBE2M	3295	-3585
UBE2N	616	1127
UBE2O	662	-5963
UBE2Q1	2309	-1272
UBE2Q2	-4499	-4146
UBE2R2	3891	-3277
UBE2S	1785	2449
UBE2V1	2217	-1021
UBE2V2	965	-3487
UBE2W	3511	-618
UBE2Z	-4161	-4538
UBE3A	984	1814
UBE3B	600	-244
UBE3C	2536	223
UBE3D	-4037	-5685
UBOX5	-303	1764
UBR1	-1448	-415
UBR2	1457	-2614
UFL1	-2146	122
UNC13D	3353	-6493
UNC93B1	1454	-4358
UNKL	-654	-4290
USP18	-4831	-2616
VAMP2	-4530	-2770
VAMP3	3630	1210
VAMP8	2013	-6050
VAPA	4183	-5592
VASP	3638	-2892
VAT1	4324	-3481
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCL	3178	-5870
VCP	2927	-2411
VEGFA	3184	-2723
VHL	1285	1389
VIM	4364	-2247
VRK3	402	-1398
VTN	-615	2265
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WDR83	1306	840
WIPF1	182	-4382
WIPF2	2264	-2523
WSB1	3452	-637
WWP1	-3587	-1865
XAF1	-4776	-2525
XRCC5	2099	-3770
XRCC6	-1338	376
YES1	-4790	-4415
YPEL5	2795	-1479
YWHAB	2609	2125
YWHAZ	2220	541
ZAP70	-4612	2499
ZBP1	-4859	-410
ZBTB16	391	2289
ZEB1	-2241	-1406
ZNRF1	3356	-5381
ZNRF2	227	1850

---

---

Vesicle-mediated transport

Vesicle-mediated transport

metric	value
setSize	442
pMANOVA	1.98e-20
p.adjustMANOVA	5.17e-18
s.dist	0.266
s.RNA	0.266
s.meth	3.47e-05
p.RNA	2.25e-21
p.meth	0.999

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
KDELR1	4237	1780
AP3S1	3472	2039
TMED7	3495	1939
TRAPPC8	2851	2300
AGFG1	4282	1439
MYH9	2818	2182
PPP6C	2885	2020
YWHAB	2609	2125
STX6	3494	1575
CBL	3300	1456
GOLGA2	2510	1847
VAMP3	3630	1210
VPS25	3359	1235
RAB14	3005	1334
COPA	3748	1056
RAC1	3977	971
SYNJ1	2561	1501
PAFAH1B1	2142	1763
SURF4	3043	1222

Click HERE to show all gene set members

All member genes

	RNA	meth
AAK1	-3233	-2582
ACBD3	2324	-912
ACTR10	3334	-1291
ACTR1A	3003	-1
ACTR2	3442	-3374
ACTR3	3481	-2917
ADRB2	-4638	-3531
AGFG1	4282	1439
AGPAT3	1685	-2039
AKT1	1248	-1942
AKT2	108	-141
ALS2CL	-2532	-5896
ANK1	4083	-4221
ANK3	-1508	-6563
ANKRD27	90	597
ANKRD28	-1964	-5108
AP1B1	3990	-463
AP1G1	1421	516
AP1G2	-1647	-5312
AP1M1	2828	-2408
AP1S3	-1711	-5455
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
AP3B1	3779	-3148
AP3S1	3472	2039
AP4B1	-2373	-4089
AP4E1	2626	-5749
AP4M1	70	2409
AP4S1	-1763	-2809
APP	4212	-5300
ARCN1	2206	-1676
ARF1	4190	-6686
ARF3	3423	-1912
ARF4	4255	-3280
ARF5	3536	-4789
ARF6	431	-3567
ARFGAP1	-583	1688
ARFGAP3	1308	-5386
ARFIP2	-932	2033
ARFRP1	-2428	-501
ARL1	-1559	-4570
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ARRB1	659	-6363
ARRB2	3858	-2243
ASPSCR1	-1567	1072
BET1	-202	-4482
BET1L	-2386	332
BICD1	-2364	-5311
BICD2	4021	-4361
BIN1	-4225	2405
BLOC1S1	3981	-5160
BLOC1S3	-2999	-59
BLOC1S6	2843	-2929
BNIP1	-2456	-1561
C2CD5	-2526	-3136
CALM1	-614	-5019
CALR	2620	-3753
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CBL	3300	1456
CCZ1	1539	2069
CD3D	-4167	2493
CD4	-1631	-6372
CD55	4233	-3923
CD59	2365	-6024
CENPE	232	-4165
CHMP2A	4065	-297
CHMP2B	2237	-4000
CHMP3	3762	-2694
CHMP4A	794	458
CHMP4B	4045	-4297
CHMP5	1842	-2010
CHMP6	2172	-2539
CHMP7	-2791	-1608
CLINT1	1349	-6738
CLTA	3793	-5077
CLTB	2497	-3627
CLTC	4170	2477
CLTCL1	4107	-4995
CNIH1	3446	-6699
COG1	-4741	-3663
COG2	-2655	-6132
COG3	-1593	-5701
COG4	1	-984
COG5	-985	-1864
COG6	-1803	-358
COG7	1546	-4196
COG8	-131	1846
COPA	3748	1056
COPB1	3188	-1329
COPB2	3530	-1501
COPE	2941	213
COPS2	2465	896
COPS3	2406	-2950
COPS4	587	-3507
COPS5	1597	-1617
COPS6	516	-866
COPS7A	2748	-565
COPS7B	-3523	538
COPS8	-3027	-4126
COPZ1	1431	-5051
COPZ2	-4133	1305
CPD	4086	-6376
CSNK1D	771	-1777
CTSC	817	1561
CTSZ	4137	-6765
CUX1	4088	-2129
CYTH1	-4809	-1796
CYTH2	143	-4454
CYTH3	-2819	-1946
CYTH4	2479	-966
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DENND1A	3193	-1692
DENND1B	-3308	2496
DENND1C	-2348	-987
DENND2C	2418	-5517
DENND2D	-4798	2236
DENND3	3541	-5361
DENND4A	-1668	-3677
DENND4B	1041	-5604
DENND5A	3388	-2375
DENND6A	-130	-223
DNM1	1196	-5619
DNM2	2474	738
DTNBP1	364	-1025
DVL2	-3982	-1356
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
EPN1	3574	-2171
EPN2	-1181	-748
EPS15	1476	-654
EPS15L1	1262	-3901
EXOC1	2235	-2298
EXOC2	-2543	1713
EXOC3	1758	-3415
EXOC4	2207	-3655
EXOC5	1473	1408
EXOC6	4057	-5526
EXOC7	1867	-4686
EXOC8	-8	2121
FCHO1	-607	-444
FCHO2	3399	-2751
FNBP1	-104	934
FTH1	1806	-521
FTL	3959	-4621
GABARAP	3532	-3859
GABARAPL2	4229	-3733
GAK	838	-380
GALNT2	4082	-5164
GAPVD1	2874	-3999
GBF1	-1292	-120
GCC1	889	-5585
GCC2	-2539	-3284
GDI2	3151	-587
GGA1	745	-3812
GGA2	-2039	-3081
GGA3	1328	450
GJD3	3590	-708
GNS	4312	-571
GOLGA1	790	-3121
GOLGA2	2510	1847
GOLGA4	-1210	-155
GOLGA5	2041	-4117
GOLGB1	-1656	-3196
GOLIM4	1933	-5765
GORASP1	2763	-2178
GOSR1	-51	-3152
GOSR2	-462	1643
GPS1	-1373	-6247
GRB2	4321	-2295
HBEGF	1808	-6428
HGS	1660	2123
HIP1	3819	107
HIP1R	-3598	-3324
HPS1	2215	-2664
HPS4	-4402	-1809
HSP90AA1	415	-781
HSP90B1	655	-1371
HSPH1	-3193	993
HYOU1	-32	-3315
IGF2R	3116	-5512
ITSN1	4248	-1048
ITSN2	1928	1310
KDELR1	4237	1780
KDELR2	3293	-2980
KIAA0319	1119	-1089
KIF11	306	-4751
KIF13B	2412	-3303
KIF15	-963	-563
KIF16B	905	-6359
KIF18A	-818	-2125
KIF18B	-35	-3342
KIF1B	3730	-4142
KIF20A	1956	-231
KIF20B	-2609	-649
KIF21A	-4610	-1704
KIF21B	-2139	1128
KIF22	-4864	-1801
KIF23	2168	-3340
KIF26B	-4519	-6613
KIF27	826	-1527
KIF2A	-332	1788
KIF2C	262	-1625
KIF3A	-4676	-2118
KIF3B	1297	-2584
KIF3C	3823	-5135
KIF5B	3643	-3520
KIF6	367	-5646
KIF9	1537	-2489
KIFAP3	-2987	1836
KIFC1	-53	901
KIFC2	-477	-5893
KLC1	2174	-1283
KLC2	-2966	-5681
KLC4	-2743	-4132
LDLR	2573	-494
LDLRAP1	-3040	643
LMAN1	-3951	596
LMAN2	3064	-2497
LMAN2L	2953	-1590
LNPEP	-3482	-478
M6PR	-2941	246
MADD	-4664	-6381
MAN1A1	3539	-447
MAN1A2	-601	-1465
MAN1C1	-2013	-1205
MAN2A1	-406	-4486
MAN2A2	2762	-5172
MCFD2	3037	-158
MIA3	-1970	-3428
MON1A	-907	-4568
MON1B	2791	-2596
MVB12A	3203	272
MYH9	2818	2182
MYO6	-4422	-3265
NAA30	-3390	-2261
NAA35	-4380	-570
NAA38	3278	-540
NAPA	425	-4125
NAPB	-827	471
NAPG	1477	-97
NBAS	61	-3794
NECAP1	713	703
NECAP2	1150	-3453
NEDD8	2723	-1600
OPTN	-4568	-5087
PACSIN1	-4882	-5957
PACSIN2	3684	-4162
PAFAH1B1	2142	1763
PAFAH1B2	2967	-1392
PAFAH1B3	1576	-434
PICALM	4168	-6069
PIP5K1C	1156	-5383
PLA2G6	-4717	-3132
PLIN3	4396	-3203
POLG	-3536	728
PPP6C	2885	2020
PPP6R1	2037	-1276
PPP6R3	1102	-3726
PRKAB1	405	-3297
PRKAB2	-2683	-1428
PRKAG1	2166	-5980
PRKAG2	612	-5033
PUM1	1104	2120
RAB10	4097	-3437
RAB11A	3974	-2965
RAB11B	1610	-387
RAB12	-282	-1635
RAB14	3005	1334
RAB18	3484	-1995
RAB1A	4185	-1703
RAB1B	3794	-264
RAB27A	3850	-1181
RAB30	-3074	-2803
RAB33B	3182	547
RAB35	1406	780
RAB3A	3705	-1080
RAB3GAP1	2277	-189
RAB3GAP2	1627	-3103
RAB3IP	1083	483
RAB43	2675	1154
RAB4A	3589	-5479
RAB5A	3055	-1686
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAB8A	1340	-1289
RAB8B	2729	79
RABEP1	-4541	-119
RABEPK	1633	-3599
RABGAP1	654	1231
RABGEF1	3283	-5431
RAC1	3977	971
RACGAP1	937	1472
RALA	865	-262
RALGAPA2	4080	-5734
RALGAPB	-1237	-1988
REPS1	-2323	1890
RGP1	1675	-1273
RHOBTB3	-4256	-6232
RHOQ	3247	-1953
RIC1	2800	-4947
RIN1	3285	-1629
RINL	-3848	1118
RINT1	-3662	1777
RPS27A	-2186	-2138
SAR1B	2704	489
SBF1	-3855	882
SCARB1	2379	-4202
SCARB2	1856	-5779
SCOC	-286	-4230
SEC13	2286	-3749
SEC16A	1717	-1722
SEC22A	-1547	696
SEC22C	-1274	1879
SEC23A	3198	-5141
SEC23IP	-149	-38
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SFN	478	-5994
SH3GL1	3385	1075
SNAP23	3895	-6016
SNAP29	2623	-4157
SNAPIN	3263	-4279
SNF8	2382	-2157
SNX18	3017	-1832
SNX2	3437	-4403
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SRC	-3100	-4427
STAM	404	770
STAM2	2488	-2181
STX10	4163	-1571
STX16	1296	-15
STX17	-4112	-4247
STX18	1716	-16
STX4	200	-6001
STX5	3070	-1823
STX6	3494	1575
STXBP3	3213	-1306
SURF4	3043	1222
SYNJ1	2561	1501
SYNJ2	-2891	-6043
SYS1	105	-3479
SYT11	-2073	-3074
SYTL1	-3447	-5731
TBC1D1	3026	-6278
TBC1D10A	-4730	-5496
TBC1D10B	3653	-2223
TBC1D10C	-4450	2261
TBC1D13	1318	-4987
TBC1D14	4133	-5797
TBC1D15	1255	-2913
TBC1D17	-2960	1402
TBC1D2	4343	-3011
TBC1D20	-16	-5205
TBC1D24	1069	-3543
TBC1D4	-3656	-1780
TBC1D7	2703	-2436
TFRC	484	-273
TGFA	4154	-3020
TGOLN2	3932	-2836
TMED10	104	604
TMED2	2437	-3656
TMED3	893	-2936
TMED7	3495	1939
TMED9	3079	-1992
TMEM115	2179	-703
TMF1	808	277
TOR1A	3609	-4691
TOR1B	-579	1023
TPD52	-3278	-32
TRAPPC1	3480	-3029
TRAPPC10	-3321	2388
TRAPPC12	2606	1388
TRAPPC13	-746	2360
TRAPPC2L	-690	1441
TRAPPC3	3050	-2853
TRAPPC4	-2164	-3231
TRAPPC5	2001	-5629
TRAPPC6A	-4070	1765
TRAPPC6B	1486	-662
TRAPPC8	2851	2300
TRAPPC9	2076	-4354
TRIP11	-187	1568
TSC1	-627	1527
TSC2	-257	895
TSG101	3465	-5032
TXNDC5	174	-5179
UBA52	344	752
UBAP1	4015	-2481
UBB	2801	-1321
UBC	1599	-2568
UBQLN1	1955	-5425
ULK1	3041	-4553
USE1	297	-4077
USO1	1479	1196
USP6NL	1630	-2335
VAMP2	-4530	-2770
VAMP3	3630	1210
VAMP4	1062	193
VAMP8	2013	-6050
VPS25	3359	1235
VPS28	1503	-2471
VPS36	-2208	-2008
VPS37A	2702	-3512
VPS37B	1362	-6110
VPS37C	3535	421
VPS45	809	-3464
VPS4A	247	118
VPS51	-2055	-1460
VPS52	-1073	-1717
VPS53	-39	-3026
VPS54	3280	-4194
VTA1	2518	-3898
VTI1A	2064	-3252
WASL	91	-4742
YKT6	2009	-3331
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541
ZW10	11	160

---

---

Membrane Trafficking

Membrane Trafficking

metric	value
setSize	436
pMANOVA	2.31e-20
p.adjustMANOVA	5.17e-18
s.dist	0.268
s.RNA	0.268
s.meth	-0.000137
p.RNA	2.61e-21
p.meth	0.996

Top 20 genes

Gene	RNA	meth
ARF1	4190	-6686
CTSZ	4137	-6765
CPD	4086	-6376
DCTN2	4234	-6011
PICALM	4168	-6069
TBC1D14	4133	-5797
YWHAG	4313	-5545
SNAP23	3895	-6016
RALGAPA2	4080	-5734
CNIH1	3446	-6699
EXOC6	4057	-5526
RAB7A	4011	-5570
APP	4212	-5300
GALNT2	4082	-5164
BLOC1S1	3981	-5160
CLTCL1	4107	-4995
RAB4A	3589	-5479
KIF3C	3823	-5135
CLTA	3793	-5077
TBC1D1	3026	-6278

Click HERE to show all gene set members

All member genes

	RNA	meth
AAK1	-3233	-2582
ACBD3	2324	-912
ACTR10	3334	-1291
ACTR1A	3003	-1
ACTR2	3442	-3374
ACTR3	3481	-2917
ADRB2	-4638	-3531
AGFG1	4282	1439
AGPAT3	1685	-2039
AKT1	1248	-1942
AKT2	108	-141
ALS2CL	-2532	-5896
ANK1	4083	-4221
ANK3	-1508	-6563
ANKRD27	90	597
ANKRD28	-1964	-5108
AP1B1	3990	-463
AP1G1	1421	516
AP1G2	-1647	-5312
AP1M1	2828	-2408
AP1S3	-1711	-5455
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
AP3B1	3779	-3148
AP3S1	3472	2039
AP4B1	-2373	-4089
AP4E1	2626	-5749
AP4M1	70	2409
AP4S1	-1763	-2809
APP	4212	-5300
ARCN1	2206	-1676
ARF1	4190	-6686
ARF3	3423	-1912
ARF4	4255	-3280
ARF5	3536	-4789
ARF6	431	-3567
ARFGAP1	-583	1688
ARFGAP3	1308	-5386
ARFIP2	-932	2033
ARFRP1	-2428	-501
ARL1	-1559	-4570
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ARRB1	659	-6363
ARRB2	3858	-2243
ASPSCR1	-1567	1072
BET1	-202	-4482
BET1L	-2386	332
BICD1	-2364	-5311
BICD2	4021	-4361
BIN1	-4225	2405
BLOC1S1	3981	-5160
BLOC1S3	-2999	-59
BLOC1S6	2843	-2929
BNIP1	-2456	-1561
C2CD5	-2526	-3136
CALM1	-614	-5019
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CBL	3300	1456
CCZ1	1539	2069
CD3D	-4167	2493
CD4	-1631	-6372
CD55	4233	-3923
CD59	2365	-6024
CENPE	232	-4165
CHMP2A	4065	-297
CHMP2B	2237	-4000
CHMP3	3762	-2694
CHMP4A	794	458
CHMP4B	4045	-4297
CHMP5	1842	-2010
CHMP6	2172	-2539
CHMP7	-2791	-1608
CLINT1	1349	-6738
CLTA	3793	-5077
CLTB	2497	-3627
CLTC	4170	2477
CLTCL1	4107	-4995
CNIH1	3446	-6699
COG1	-4741	-3663
COG2	-2655	-6132
COG3	-1593	-5701
COG4	1	-984
COG5	-985	-1864
COG6	-1803	-358
COG7	1546	-4196
COG8	-131	1846
COPA	3748	1056
COPB1	3188	-1329
COPB2	3530	-1501
COPE	2941	213
COPS2	2465	896
COPS3	2406	-2950
COPS4	587	-3507
COPS5	1597	-1617
COPS6	516	-866
COPS7A	2748	-565
COPS7B	-3523	538
COPS8	-3027	-4126
COPZ1	1431	-5051
COPZ2	-4133	1305
CPD	4086	-6376
CSNK1D	771	-1777
CTSC	817	1561
CTSZ	4137	-6765
CUX1	4088	-2129
CYTH1	-4809	-1796
CYTH2	143	-4454
CYTH3	-2819	-1946
CYTH4	2479	-966
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DENND1A	3193	-1692
DENND1B	-3308	2496
DENND1C	-2348	-987
DENND2C	2418	-5517
DENND2D	-4798	2236
DENND3	3541	-5361
DENND4A	-1668	-3677
DENND4B	1041	-5604
DENND5A	3388	-2375
DENND6A	-130	-223
DNM1	1196	-5619
DNM2	2474	738
DTNBP1	364	-1025
DVL2	-3982	-1356
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
EPN1	3574	-2171
EPN2	-1181	-748
EPS15	1476	-654
EPS15L1	1262	-3901
EXOC1	2235	-2298
EXOC2	-2543	1713
EXOC3	1758	-3415
EXOC4	2207	-3655
EXOC5	1473	1408
EXOC6	4057	-5526
EXOC7	1867	-4686
EXOC8	-8	2121
FCHO1	-607	-444
FCHO2	3399	-2751
FNBP1	-104	934
FTH1	1806	-521
FTL	3959	-4621
GABARAP	3532	-3859
GABARAPL2	4229	-3733
GAK	838	-380
GALNT2	4082	-5164
GAPVD1	2874	-3999
GBF1	-1292	-120
GCC1	889	-5585
GCC2	-2539	-3284
GDI2	3151	-587
GGA1	745	-3812
GGA2	-2039	-3081
GGA3	1328	450
GJD3	3590	-708
GNS	4312	-571
GOLGA1	790	-3121
GOLGA2	2510	1847
GOLGA4	-1210	-155
GOLGA5	2041	-4117
GOLGB1	-1656	-3196
GOLIM4	1933	-5765
GORASP1	2763	-2178
GOSR1	-51	-3152
GOSR2	-462	1643
GPS1	-1373	-6247
GRB2	4321	-2295
HBEGF	1808	-6428
HGS	1660	2123
HIP1	3819	107
HIP1R	-3598	-3324
HPS1	2215	-2664
HPS4	-4402	-1809
IGF2R	3116	-5512
ITSN1	4248	-1048
ITSN2	1928	1310
KDELR1	4237	1780
KDELR2	3293	-2980
KIAA0319	1119	-1089
KIF11	306	-4751
KIF13B	2412	-3303
KIF15	-963	-563
KIF16B	905	-6359
KIF18A	-818	-2125
KIF18B	-35	-3342
KIF1B	3730	-4142
KIF20A	1956	-231
KIF20B	-2609	-649
KIF21A	-4610	-1704
KIF21B	-2139	1128
KIF22	-4864	-1801
KIF23	2168	-3340
KIF26B	-4519	-6613
KIF27	826	-1527
KIF2A	-332	1788
KIF2C	262	-1625
KIF3A	-4676	-2118
KIF3B	1297	-2584
KIF3C	3823	-5135
KIF5B	3643	-3520
KIF6	367	-5646
KIF9	1537	-2489
KIFAP3	-2987	1836
KIFC1	-53	901
KIFC2	-477	-5893
KLC1	2174	-1283
KLC2	-2966	-5681
KLC4	-2743	-4132
LDLR	2573	-494
LDLRAP1	-3040	643
LMAN1	-3951	596
LMAN2	3064	-2497
LMAN2L	2953	-1590
LNPEP	-3482	-478
M6PR	-2941	246
MADD	-4664	-6381
MAN1A1	3539	-447
MAN1A2	-601	-1465
MAN1C1	-2013	-1205
MAN2A1	-406	-4486
MAN2A2	2762	-5172
MCFD2	3037	-158
MIA3	-1970	-3428
MON1A	-907	-4568
MON1B	2791	-2596
MVB12A	3203	272
MYH9	2818	2182
MYO6	-4422	-3265
NAA30	-3390	-2261
NAA35	-4380	-570
NAA38	3278	-540
NAPA	425	-4125
NAPB	-827	471
NAPG	1477	-97
NBAS	61	-3794
NECAP1	713	703
NECAP2	1150	-3453
NEDD8	2723	-1600
OPTN	-4568	-5087
PACSIN1	-4882	-5957
PACSIN2	3684	-4162
PAFAH1B1	2142	1763
PAFAH1B2	2967	-1392
PAFAH1B3	1576	-434
PICALM	4168	-6069
PIP5K1C	1156	-5383
PLA2G6	-4717	-3132
PLIN3	4396	-3203
POLG	-3536	728
PPP6C	2885	2020
PPP6R1	2037	-1276
PPP6R3	1102	-3726
PRKAB1	405	-3297
PRKAB2	-2683	-1428
PRKAG1	2166	-5980
PRKAG2	612	-5033
PUM1	1104	2120
RAB10	4097	-3437
RAB11A	3974	-2965
RAB11B	1610	-387
RAB12	-282	-1635
RAB14	3005	1334
RAB18	3484	-1995
RAB1A	4185	-1703
RAB1B	3794	-264
RAB27A	3850	-1181
RAB30	-3074	-2803
RAB33B	3182	547
RAB35	1406	780
RAB3A	3705	-1080
RAB3GAP1	2277	-189
RAB3GAP2	1627	-3103
RAB3IP	1083	483
RAB43	2675	1154
RAB4A	3589	-5479
RAB5A	3055	-1686
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAB8A	1340	-1289
RAB8B	2729	79
RABEP1	-4541	-119
RABEPK	1633	-3599
RABGAP1	654	1231
RABGEF1	3283	-5431
RAC1	3977	971
RACGAP1	937	1472
RALA	865	-262
RALGAPA2	4080	-5734
RALGAPB	-1237	-1988
REPS1	-2323	1890
RGP1	1675	-1273
RHOBTB3	-4256	-6232
RHOQ	3247	-1953
RIC1	2800	-4947
RIN1	3285	-1629
RINL	-3848	1118
RINT1	-3662	1777
RPS27A	-2186	-2138
SAR1B	2704	489
SBF1	-3855	882
SCARB2	1856	-5779
SCOC	-286	-4230
SEC13	2286	-3749
SEC16A	1717	-1722
SEC22A	-1547	696
SEC22C	-1274	1879
SEC23A	3198	-5141
SEC23IP	-149	-38
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SFN	478	-5994
SH3GL1	3385	1075
SNAP23	3895	-6016
SNAP29	2623	-4157
SNAPIN	3263	-4279
SNF8	2382	-2157
SNX18	3017	-1832
SNX2	3437	-4403
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SRC	-3100	-4427
STAM	404	770
STAM2	2488	-2181
STX10	4163	-1571
STX16	1296	-15
STX17	-4112	-4247
STX18	1716	-16
STX4	200	-6001
STX5	3070	-1823
STX6	3494	1575
STXBP3	3213	-1306
SURF4	3043	1222
SYNJ1	2561	1501
SYNJ2	-2891	-6043
SYS1	105	-3479
SYT11	-2073	-3074
SYTL1	-3447	-5731
TBC1D1	3026	-6278
TBC1D10A	-4730	-5496
TBC1D10B	3653	-2223
TBC1D10C	-4450	2261
TBC1D13	1318	-4987
TBC1D14	4133	-5797
TBC1D15	1255	-2913
TBC1D17	-2960	1402
TBC1D2	4343	-3011
TBC1D20	-16	-5205
TBC1D24	1069	-3543
TBC1D4	-3656	-1780
TBC1D7	2703	-2436
TFRC	484	-273
TGFA	4154	-3020
TGOLN2	3932	-2836
TMED10	104	604
TMED2	2437	-3656
TMED3	893	-2936
TMED7	3495	1939
TMED9	3079	-1992
TMEM115	2179	-703
TMF1	808	277
TOR1A	3609	-4691
TOR1B	-579	1023
TPD52	-3278	-32
TRAPPC1	3480	-3029
TRAPPC10	-3321	2388
TRAPPC12	2606	1388
TRAPPC13	-746	2360
TRAPPC2L	-690	1441
TRAPPC3	3050	-2853
TRAPPC4	-2164	-3231
TRAPPC5	2001	-5629
TRAPPC6A	-4070	1765
TRAPPC6B	1486	-662
TRAPPC8	2851	2300
TRAPPC9	2076	-4354
TRIP11	-187	1568
TSC1	-627	1527
TSC2	-257	895
TSG101	3465	-5032
TXNDC5	174	-5179
UBA52	344	752
UBAP1	4015	-2481
UBB	2801	-1321
UBC	1599	-2568
UBQLN1	1955	-5425
ULK1	3041	-4553
USE1	297	-4077
USO1	1479	1196
USP6NL	1630	-2335
VAMP2	-4530	-2770
VAMP3	3630	1210
VAMP4	1062	193
VAMP8	2013	-6050
VPS25	3359	1235
VPS28	1503	-2471
VPS36	-2208	-2008
VPS37A	2702	-3512
VPS37B	1362	-6110
VPS37C	3535	421
VPS45	809	-3464
VPS4A	247	118
VPS51	-2055	-1460
VPS52	-1073	-1717
VPS53	-39	-3026
VPS54	3280	-4194
VTA1	2518	-3898
VTI1A	2064	-3252
WASL	91	-4742
YKT6	2009	-3331
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541
ZW10	11	160

---

---

Signal Transduction

Signal Transduction

metric	value
setSize	1172
pMANOVA	3.07e-18
p.adjustMANOVA	5.73e-16
s.dist	0.159
s.RNA	0.157
s.meth	0.0265
p.RNA	3.16e-18
p.meth	0.141

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
FURIN	4236	2351
SOCS3	4414	2178
NTSR1	4067	2286
PTPRJ	3447	2365
ADAP1	3329	2385
DGKG	3467	2259
GNG5	4068	1920
PHC2	4201	1830
CTSD	4393	1642
ECE1	3728	1921
ACTG1	3946	1793
RNF146	3919	1789
ATP6V1A	4307	1580
LRP10	3078	2161
RGS14	2955	2215
ATP6V0B	3961	1604
LAMTOR2	3365	1882
MYH9	2818	2182
PPP2CB	3404	1797

Click HERE to show all gene set members

All member genes

	RNA	meth
AAMP	-1094	-5298
AATF	1640	1712
ABCA1	2422	-6487
ABCG1	-2674	2179
ABHD12	-3885	-129
ABHD17A	-3997	902
ABHD17B	-13	-1287
ABHD6	-644	-284
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ABR	2475	-1237
ACTA2	-140	-3190
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ACVR1B	4205	-6300
ACVR2A	-4355	-4829
ADAM10	3964	976
ADAM17	3540	774
ADAP1	3329	2385
ADCY4	1985	-6389
ADCY7	-982	-5596
ADCY9	46	-2618
ADGRE5	-743	-5511
ADM	4381	-6151
ADORA2A	1055	-5935
ADORA3	2371	-6581
ADRB2	-4638	-3531
AGO1	2205	1997
AGO2	983	2447
AGO3	-318	-6442
AGRN	-4590	-2304
AHCTF1	-492	-3122
AHCYL1	2655	-3553
AKAP13	1152	-2154
AKT1	1248	-1942
AKT1S1	3491	-2319
AKT2	108	-141
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
APBB1IP	4055	-5120
APC	1087	-4775
APH1A	1483	-6066
APH1B	2525	2056
APP	4212	-5300
ARAP1	3441	-1837
ARAP2	-4710	1602
ARF6	431	-3567
ARHGAP1	1708	-1385
ARHGAP10	-3063	2322
ARHGAP11A	536	1998
ARHGAP11B	-2545	-695
ARHGAP12	-2512	-1220
ARHGAP15	67	-1044
ARHGAP17	-2601	-1278
ARHGAP18	4074	-4990
ARHGAP19	3424	-1466
ARHGAP21	1888	-3300
ARHGAP23	2145	2467
ARHGAP25	-2913	-6181
ARHGAP26	3799	-2076
ARHGAP27	2320	-6332
ARHGAP30	1927	1011
ARHGAP35	-1007	-3660
ARHGAP39	-2401	-5852
ARHGAP5	-3022	-1039
ARHGAP9	2546	2156
ARHGDIA	2469	2217
ARHGDIB	3967	661
ARHGEF1	-1664	1695
ARHGEF12	1058	-4362
ARHGEF17	2904	-75
ARHGEF19	-2957	-1607
ARHGEF2	2747	-4190
ARHGEF26	-1119	-6309
ARHGEF3	-4736	-1916
ARHGEF39	-4113	-4135
ARHGEF7	-1390	-5507
ARL2	-203	-4526
ARL4C	-4844	1933
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ARRB1	659	-6363
ARRB2	3858	-2243
ASH2L	2381	-3791
ATF1	2271	-2565
ATN1	99	-5111
ATP2A1	-1323	-4587
ATP2A2	3601	1489
ATP2A3	-315	1190
ATP6V0A1	4395	-5877
ATP6V0A2	-4820	689
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
AURKB	309	-889
AXIN1	-3733	-5655
AXIN2	-2404	-4719
B4GALT1	1562	-160
B9D2	3715	-881
BAD	2952	-1382
BAG4	3782	-3089
BAIAP2	-56	1977
BAMBI	3914	-6108
BAX	2386	-3623
BCL2	-1339	2361
BCL2L1	4028	1306
BCL2L11	3144	1781
BCL9	-362	-4834
BCR	-2308	-6682
BIRC2	1750	-1862
BIRC3	-4025	-2320
BIRC5	1432	-84
BMI1	-3450	-6383
BMPR1A	-2724	2273
BMPR2	1179	1438
BRAF	406	-4347
BRAP	2050	-3662
BRK1	3002	1970
BTRC	-1491	-2427
BUB1	1142	-3844
BUB1B	1010	-3456
BUB3	-4435	-1487
C3AR1	3600	-6729
CAB39	3774	-2802
CAB39L	-156	-190
CALM1	-614	-5019
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAMK4	-3176	1482
CAMKK1	2621	1958
CAMKK2	3632	-6236
CASP10	-1033	-6612
CASP3	-160	-2764
CASP8	-4381	387
CASP9	3414	-234
CAV1	584	-2432
CBFB	680	-3766
CBL	3300	1456
CBX4	706	-5288
CBX6	1438	-3511
CBX8	2136	2207
CBY1	-3503	-1167
CCDC88C	-4708	2395
CCNC	596	-1138
CCND1	-2169	-6213
CCND3	3252	905
CCNE1	-4509	-3403
CCNK	942	-6142
CCNT1	-3342	1773
CCR1	4062	-6480
CCR10	-233	-1621
CCR7	-2264	2398
CD55	4233	-3923
CDC14A	-3615	-2150
CDC14B	518	1657
CDC20	1435	116
CDC25C	1885	-2877
CDC42	3265	-2719
CDC42EP3	4108	-1099
CDC73	1921	-2092
CDCA8	-556	472
CDK1	454	-4215
CDK2	-1524	1018
CDK4	-4195	-1295
CDK5	3942	-506
CDK5R1	-356	-2113
CDK8	-597	-5509
CDK9	-1184	1524
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDON	-2371	-2931
CENPA	1511	631
CENPE	232	-4165
CENPF	928	-1452
CENPH	-2975	-5334
CENPK	-2859	-1370
CENPL	-4596	-2599
CENPM	-1644	1202
CENPN	5	936
CENPO	-1585	-1800
CENPP	-4626	-3972
CENPQ	-2011	-3488
CENPT	-3276	-3323
CENPU	-2028	-3857
CFL1	3703	912
CFLAR	3336	197
CHD1	-2	-1222
CHD3	-3299	422
CHD4	-1372	-4634
CHD8	206	-6248
CHEK1	-752	-211
CHN1	-2672	-4729
CHUK	3527	1343
CIT	-1520	1151
CKAP5	-1960	-4385
CLASP1	-182	-390
CLASP2	-647	-4366
CLIP1	3836	-5910
CLIP3	-3365	-5251
CLTA	3793	-5077
CLTB	2497	-3627
CLTC	4170	2477
CNOT6L	-4344	-5686
CNR2	-2498	-6656
COL9A2	-3547	-2895
CPT1A	1949	-6398
CREB1	-423	-672
CREBBP	1169	-5804
CRK	4109	-4581
CRKL	1383	-906
CSK	2014	862
CSNK1A1	3434	769
CSNK1E	-3694	-4750
CSNK1G2	289	-1639
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CTBP1	-2048	2394
CTNNB1	2647	-1691
CTNNBIP1	3325	1401
CTNND1	-2884	1566
CTSD	4393	1642
CUL1	-4385	-5146
CUL3	2907	2054
CUL5	269	-3077
CXCL2	2131	-6755
CXCR4	-37	-1660
CXXC5	-2333	-4582
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
CYLD	-3106	1406
CYP4V2	-3320	-4041
DAAM1	1219	-4155
DACT1	335	-4564
DAGLB	2332	-6635
DDX5	-3458	1288
DEPDC1B	567	-5291
DEPDC7	314	-6604
DERL2	1003	-2287
DGKA	-2494	2375
DGKD	-165	546
DGKE	-4343	-953
DGKG	3467	2259
DGKH	-950	-6190
DGKQ	-2756	1446
DGKZ	-1727	-6294
DHRS3	-4752	-4924
DHRS4	1320	740
DIAPH1	-221	1033
DISP2	-2321	-4171
DLAT	-1052	-1484
DLD	3104	1320
DLG1	-2798	-3985
DLG2	-1714	1854
DLG4	4181	-3021
DLGAP5	1039	-2706
DNAJB1	-1723	-3687
DNAL4	1131	-45
DNM1	1196	-5619
DNM2	2474	738
DOCK7	-717	-5883
DRAP1	-2200	-2142
DSN1	-4082	369
DTX4	2517	1530
DUSP1	2979	238
DUSP10	-486	-1469
DUSP16	-2084	-2622
DUSP2	-3348	616
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP5	-4824	1801
DUSP6	1572	-6763
DUSP7	-965	-1322
DVL1	19	-4520
DVL2	-3982	-1356
DVL3	2248	-3704
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNC2H1	-2652	-2623
DYNLL1	2413	-3319
DYNLL2	-1200	214
E2F1	2654	-1005
E2F3	2805	-2884
E2F4	2607	-172
E2F5	-2781	-2646
EBAG9	-3738	-2026
ECE1	3728	1921
ECT2	2170	-2378
EED	-3277	-1174
EEF2K	-4185	-2191
EEPD1	2579	-5914
EFCAB7	-1563	-5871
EGR1	955	-163
EGR2	-635	-2628
EIF4B	387	-4336
EIF4E	1815	1536
EIF4EBP1	2454	150
EIF4G1	3607	746
ELMO1	2569	-2714
ELMO2	1638	1326
EP300	2504	-4509
EPAS1	3555	535
EPN1	3574	-2171
EPOR	3053	-3354
EPS15	1476	-654
EPS15L1	1262	-3901
ERBB2	-4860	-5145
ERLEC1	246	-2711
ESR2	-3196	-2661
ESRP2	-3028	-6611
ETV4	-1017	1547
EVL	-4735	2303
EZH2	-3517	-20
F11R	3640	-5665
FABP5	2453	-3534
FADD	2255	-6328
FAM13A	3186	-5682
FAM13B	-3931	2059
FAS	1270	-5824
FASN	-220	1100
FBXW7	-2109	-5428
FER	554	-3332
FES	4294	-6334
FGD3	1144	-720
FGF9	-3030	1634
FGFBP3	-3186	1
FGFRL1	-4616	-2409
FKBP1A	4177	-4465
FKBP4	253	-4442
FKBP5	4105	-5653
FLT3LG	-3269	1573
FMNL1	1478	1919
FMNL3	-4629	1022
FNTA	-1750	1499
FNTB	2466	-4949
FOS	2486	2149
FOSB	441	-332
FOSL1	4094	737
FOXO1	-3171	-5036
FOXO3	3983	711
FRAT1	4025	351
FRAT2	4263	1206
FRS2	-1016	-1999
FRS3	3191	-2329
FSTL3	4347	88
FURIN	4236	2351
FUZ	236	-5859
FYN	-4569	1957
FZD2	2697	-3363
FZD3	-2159	-2823
FZD5	4425	-2513
FZD6	-1991	-6235
FZD7	-2029	-3834
FZD8	-2326	-6560
GAB2	3616	-6153
GABBR1	-667	-6350
GALNT3	633	-2941
GAS8	1652	-6325
GATA3	-4787	1861
GATAD2A	1016	-256
GATAD2B	-535	-2871
GDI2	3151	-587
GGA3	1328	450
GIPR	-4760	-2380
GLI1	981	-3214
GMIP	3501	-1646
GNA12	1135	-3386
GNA13	2328	-2285
GNA15	4401	-6690
GNAI2	3614	-1747
GNAI3	3575	-909
GNAL	-2314	855
GNAQ	4150	-6733
GNAS	3567	951
GNAT1	278	-1680
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GNRHR2	-2920	25
GOLGA7	1445	-2970
GOPC	-3406	-4388
GPAM	-3559	-4630
GPC2	-1070	-6477
GPR132	-142	688
GPR183	-4523	-6590
GPR35	2996	-6091
GPR65	1570	2382
GPR68	-4746	273
GPS2	-290	-857
GPSM2	1701	528
GPSM3	2949	-1982
GRAP2	1747	-5763
GRB10	4408	-70
GRB2	4321	-2295
GRIN2D	2300	-4745
GRK4	682	-5278
GRK5	-293	1500
GRK6	2779	-613
GRK7	-2175	1070
GSK3A	3432	-2192
GSK3B	2793	736
GTF2A1	884	271
GTF2A2	3083	-1036
GTF2F1	1892	-1723
GTF2F2	2127	-2885
HBEGF	1808	-6428
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HEBP1	3729	-6287
HEY2	-3510	2330
HGS	1660	2123
HHAT	-3114	-5389
HIF1A	3192	-3349
HNRNPF	1377	-58
HNRNPH1	-2572	-1020
HNRNPM	2005	-4945
HRAS	-989	-4780
HRH2	4409	-6490
HSD17B1	1246	1940
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSPB1	544	-4137
ICMT	-247	-71
ID1	1788	-3980
ID2	-4116	566
ID3	-2928	1995
IER3	3276	-5549
IFT122	1727	-1191
IFT140	-1315	319
IFT172	-3985	-5159
IFT52	-475	-3194
IFT57	-545	-3279
IGF1R	2402	-4939
IKBKB	-1620	-3894
IKZF1	-2546	1828
IL1RAP	3160	-456
IL2RA	-2353	-6462
IL2RB	-4875	2472
IL6R	3697	-6410
IL6ST	1389	1094
INCENP	-1866	-2850
INPP5B	-2191	-5762
INSR	3618	-2668
IQGAP1	3672	1271
IQGAP2	2544	-246
IRS1	563	-4060
IRS2	3752	-5410
ITCH	429	-1366
ITGA2	1463	-3856
ITGAV	2458	-5201
ITGB3BP	-2496	-3559
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
ITSN1	4248	-1048
JAK1	-4154	-1022
JAK2	834	-1751
JUN	1372	69
JUNB	2887	-3031
JUND	480	-1239
KANK1	-1164	-270
KAT2A	-3767	-5050
KAT2B	-704	-1588
KAT5	419	-650
KBTBD7	2705	-1326
KCTD6	1605	886
KDM1A	-3304	900
KDM1B	1845	1468
KDM3A	-4671	356
KDM4A	12	-2080
KDM4B	3581	-6013
KDM4C	-3844	707
KHDRBS1	939	75
KIDINS220	3019	189
KIF14	1118	-4112
KIF18A	-818	-2125
KIF2A	-332	1788
KIF2C	262	-1625
KIF3A	-4676	-2118
KIF5B	3643	-3520
KLC1	2174	-1283
KLC2	-2966	-5681
KLC4	-2743	-4132
KLHL12	3239	-238
KMT2D	1065	-6199
KNTC1	-2617	-1314
KPNA2	-2167	-874
KRAS	1294	440
KSR1	1447	2466
KTN1	1101	-2404
LAMA2	-3513	-1315
LAMB2	156	-2207
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAMTOR4	1631	-6150
LAMTOR5	3910	-5095
LATS1	-537	71
LATS2	2409	-5622
LCK	-4404	2489
LDLR	2573	-494
LEO1	26	791
LEPR	2719	-4010
LFNG	-2876	1932
LIMK1	1743	-3787
LIMK2	3673	-6093
LIN7B	-1156	-5689
LPAR2	2433	-1201
LPAR5	-4193	2234
LPAR6	-1029	2492
LRIG1	-3683	-3314
LRP10	3078	2161
LRP12	2614	-6362
LRP5	1500	1949
LRP6	252	-4544
LRP8	1683	-214
LTB4R	4058	-6121
LTB4R2	118	-5920
LYL1	3750	-6435
LYPLA1	3582	184
MAD1L1	-1527	-3166
MAD2L1	-2682	268
MADD	-4664	-6381
MAF1	2280	-3519
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K5	1370	-3572
MAP3K11	3368	-2732
MAP3K7	780	-2089
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK6	3523	-2959
MAPK7	-388	-1630
MAPK8	-3380	6
MAPKAP1	1937	1057
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MAPRE1	3363	-4451
MARK3	4010	-3461
MBD3	-172	1673
MDM2	1471	-1318
MED1	-1217	-2271
MEF2A	3577	-2822
MEF2D	-939	-3018
MEMO1	4052	-3910
MEN1	-2763	-2311
METAP1	-2830	-721
METAP2	-85	-3329
MFNG	-1824	-3250
MIB1	-895	-2718
MIS12	-3838	-4678
MKNK1	3706	1538
MKRN1	4066	-2133
MKS1	-3819	-3341
MLST8	98	287
MOB1B	3048	-5948
MOV10	-4691	-6449
MST1	260	1514
MST1R	-1732	-4446
MTA2	-2378	1649
MTA3	-3049	-1740
MTMR4	962	-1420
MTOR	-3531	-1813
MXD4	-4327	-2602
MYB	176	1502
MYD88	3613	-1927
MYH10	214	-4405
MYH9	2818	2182
MYL6	3953	-19
MYLIP	-1189	-681
MYO9A	-3363	-2971
MYO9B	2658	687
NAB1	407	-2731
NAB2	-3750	989
NAPEPLD	-2226	-4964
NBEA	-114	-6575
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCF4	4349	-6732
NCK1	-4400	-1408
NCK2	1874	-4310
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NCOA2	352	1407
NCOA3	1207	-2266
NCOR1	2375	-3738
NCOR2	3521	-4281
NCSTN	4222	-3821
NDC80	-3145	-1589
NDE1	850	1771
NDEL1	3395	1440
NEDD4	2574	-5611
NEDD4L	3534	-5066
NEDD8	2723	-1600
NELFB	121	1822
NET1	-2455	-6606
NF1	1012	-2145
NF2	-2071	-2754
NFATC1	-3230	2372
NFKBIA	2855	1159
NLK	1174	340
NLN	2806	1352
NMB	-364	-4459
NMT1	1591	-3001
NMT2	-4662	1340
NOS3	-515	-1770
NOTCH1	1739	1722
NOTCH4	-1578	-6455
NOXA1	-1687	-5872
NPHP4	506	-406
NR1H2	3254	-1471
NR1H3	-1011	-2305
NR3C1	190	-2420
NR4A1	-2135	657
NSL1	2084	-1214
NSMAF	-396	908
NTRK1	-2556	898
NTSR1	4067	2286
NUDC	-211	-134
NUF2	-1294	-474
NUMB	4383	-35
NUP107	-3879	-1197
NUP133	-2577	112
NUP160	-3773	763
NUP37	1026	-1886
NUP43	-3356	1617
NUP85	-920	317
NUP98	1015	315
OBSCN	-1858	2406
OPN3	2400	-4940
OPRL1	3518	-6696
OS9	4053	-975
OTUD3	-3909	-1582
OTUD7B	-4748	-2644
OTULIN	-222	1535
P2RY1	3509	-5377
P2RY2	2358	-5187
P4HB	3824	-1549
PAFAH1B1	2142	1763
PAG1	1436	262
PAK1	3707	-3995
PAK2	3694	-3961
PAQR3	-1174	-6242
PARD6A	-76	1063
PARP1	-4461	-5521
PCSK5	1809	-4883
PDE1B	2288	-6326
PDE2A	-232	-391
PDE3B	-4305	-4025
PDE4A	-964	820
PDE4B	-2322	-6523
PDE4C	2261	-5822
PDE4D	432	-5510
PDE6B	-4206	-3931
PDE6D	2036	-115
PDE7A	-3729	1356
PDE7B	-530	2139
PDE8A	-2171	-5556
PDHB	1526	-3400
PDHX	1556	1616
PDK1	1517	-2149
PDK2	-2699	-941
PDPK1	2505	167
PEA15	-2211	1280
PEBP1	-4273	-152
PELP1	-4029	-1579
PFN1	2155	833
PFN2	-701	-6463
PGF	-1749	1959
PHB	-914	-3178
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
PHLPP1	1249	-3320
PHLPP2	-4654	-2806
PIK3AP1	3450	-4753
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3CG	646	-2045
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R4	-1199	-3425
PIK3R5	-695	514
PIN1	-972	-1656
PIP4K2A	-691	1772
PIP4K2B	-2536	-6347
PIP4K2C	-4341	-5573
PIP5K1A	2498	-348
PIP5K1C	1156	-5383
PKN1	-594	-73
PKN2	48	1241
PKN3	-1098	-2518
PLB1	4419	-5279
PLCB2	1724	-3046
PLCB3	4136	-5846
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLEKHG2	3242	-1689
PLK1	989	-5093
PLXND1	3176	-6504
PMEPA1	-986	-5127
PMF1	1140	785
PML	-3036	549
POFUT1	673	973
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POU2F1	497	733
PPARD	-1877	660
PPM1A	3733	-3764
PPP1CA	1462	550
PPP1CB	3008	1839
PPP1CC	2576	-754
PPP1R12A	2457	-629
PPP1R12B	543	-3636
PPP1R15A	2403	-5399
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5A	2378	381
PPP2R5B	2877	-6343
PPP2R5C	-4356	2376
PPP2R5D	777	-4349
PPP2R5E	-200	-2288
PPP3CA	2571	-2165
PPP3CB	2950	517
PPP3CC	-4723	1250
PPP3R1	3702	-3276
PPP5C	-2478	-41
PRC1	355	-1963
PRDM4	-3721	1199
PREX1	2677	2109
PRKAA1	417	227
PRKAB1	405	-3297
PRKAB2	-2683	-1428
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAG1	2166	-5980
PRKAG2	612	-5033
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PRKCA	368	810
PRKCB	2983	-4518
PRKCD	4146	584
PRKCE	-2656	-5632
PRKCH	-4848	1376
PRKCI	-42	-4275
PRKCQ	-4731	1372
PRKCZ	-4414	-5220
PRMT1	-3038	-740
PROK2	4143	-6705
PRR5	-4670	-1591
PSAP	2899	-4192
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTBP1	-64	-1843
PTCH1	-4657	2048
PTCH2	-1360	-127
PTEN	3857	-1100
PTGER2	447	-5853
PTGER4	-4573	1153
PTGES3	1472	-1810
PTK2	1637	920
PTK2B	3561	40
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN12	3633	-1077
PTPN18	2351	693
PTPN2	3324	-3701
PTPN6	2483	-4586
PTPN7	-4117	-1888
PTPRA	-1354	1436
PTPRJ	3447	2365
PTPRU	-809	1974
PXN	2575	-5712
PYGO2	-4062	113
QRFP	436	-6764
RAB4A	3589	-5479
RAB4B	1059	1318
RAB6A	3692	-311
RAC1	3977	971
RAC2	1994	-868
RAC3	-978	-5670
RACGAP1	937	1472
RAD21	534	702
RAF1	3548	-314
RALA	865	-262
RALB	3837	-1081
RALBP1	2890	-607
RALGDS	-4773	1254
RANBP10	823	-5295
RANBP2	-259	-4704
RANBP9	2336	-1361
RANGAP1	-4514	1644
RAP1A	3142	323
RAP1B	1106	-1031
RAPGEF1	-3584	1868
RARA	2591	-5249
RARG	-1454	-5402
RASA1	674	-167
RASA2	-1301	1142
RASA3	-4564	205
RASAL1	-251	-3249
RASAL3	-4634	-4378
RASGRP1	-4601	2119
RASGRP2	-2706	1508
RASGRP3	-3054	-2004
RBBP4	-573	-3282
RBBP5	325	-779
RBCK1	707	-1357
RBL1	-3634	-3466
RBPJ	3993	-1118
RBX1	1413	-3241
RCC2	-1577	-2559
RCE1	-1411	-282
RCOR1	4193	-4864
RDH10	-1326	-3708
RDH11	2587	-3361
RDH13	-3949	-3495
RDH14	-3712	-3195
REEP3	2845	-4498
REEP4	3701	-4795
REEP5	3524	-4314
REEP6	-3732	54
RELA	-541	2085
REST	304	2128
RETSAT	155	-687
RGL1	3304	1731
RGL2	3270	-1001
RGS1	-1676	2271
RGS10	1730	-1251
RGS12	-4310	-4763
RGS14	2955	2215
RGS16	2512	991
RGS19	3421	-5018
RGS2	3352	-1424
RGS3	523	2448
RHEB	3346	-2334
RHOA	3688	1313
RHOB	378	-4992
RHOBTB2	-1721	-4257
RHOF	-4868	1911
RHOG	3876	860
RHOH	-3816	1825
RHOQ	3247	-1953
RHOT1	4331	-5271
RHOT2	-1650	-1902
RHPN1	-1444	-4217
RICTOR	-3355	1651
RING1	-1202	-1490
RIT1	4242	337
RNF111	2287	779
RNF146	3919	1789
RNF2	1210	-1936
RNF31	-3757	-4597
RNF41	3835	109
ROCK1	3215	-985
RPGRIP1L	-3571	456
RPS27A	-2186	-2138
RPS6	-1881	-1785
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
RPS6KB2	209	1145
RPTOR	-3833	2134
RRAGA	2580	-1657
RRAGC	1887	-2585
RRAGD	4056	-6311
RTN4	4219	-4674
RTP4	-4455	1005
RUNX1	3296	-4082
RUNX3	-4877	2402
RUVBL1	-2967	256
RYK	-3144	-5242
S1PR1	-3197	2436
S1PR2	-4456	63
S1PR4	1601	1429
SAG	316	-6674
SAV1	213	-4821
SCAI	-2567	-3053
SCD	1444	-6126
SCMH1	-1695	1397
SCRIB	-868	-6408
SDC4	2765	1193
SEC13	2286	-3749
SEH1L	-1833	-1615
SEL1L	2854	-2307
SFN	478	-5994
SFPQ	733	-1117
SGK1	1695	-6076
SH2B1	-2800	-1068
SH2B3	1357	1699
SH2D2A	-4879	2200
SH3GL1	3385	1075
SHARPIN	2373	-4167
SHB	2487	2212
SHC1	1469	-2954
SHOC2	3168	-3532
SIRT6	2566	-4139
SKA2	-3065	-106
SKI	-4099	-2431
SKIL	-194	-3633
SKP1	1561	-2290
SLC38A9	920	-3360
SMAD1	3832	-3272
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMAD5	-1404	-5678
SMAD6	3462	-3209
SMAD7	-4655	-4450
SMARCA4	1769	2317
SMC3	-592	-1642
SMPD2	749	-918
SMPD3	-4815	2463
SMURF1	-771	1321
SMURF2	-3700	-3048
SNW1	2003	946
SOCS1	1346	-2999
SOCS3	4414	2178
SOS1	-1758	-6775
SOS2	3767	-4105
SOX4	1807	-3220
SP1	3746	-3141
SPC24	766	1272
SPDL1	-4268	-5240
SPOP	371	-6184
SPOPL	3805	-5721
SPPL2A	3027	-2234
SPPL2B	-1300	-6012
SPRED1	-2940	-6227
SPRED2	2902	521
SPRED3	-2225	-4087
SPRY1	573	-5532
SPRY2	-1472	-5919
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SQSTM1	1450	-952
SRC	-3100	-4427
SREBF1	2743	-4015
SRF	3082	-1284
SRGAP1	2796	-6096
SRGAP3	-1765	-4649
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST3GAL6	2764	-5427
STAG1	-2003	-863
STAM	404	770
STAM2	2488	-2181
STARD13	1080	2455
STAT1	-4575	2195
STAT3	3649	-3606
STAT5A	2944	-6427
STAT5B	2958	-3446
STAT6	2355	-3911
STK11	709	-5709
STK3	4125	-1290
STK4	-82	-1674
STMN1	-2954	-3648
STRADA	755	-3296
STRADB	4078	-1429
STRAP	2863	-1805
STRN	1292	1051
STUB1	-337	-2168
SUFU	3984	-3385
SYDE2	-158	-2606
SYK	4194	-5054
SYNGAP1	-2974	-2744
SYVN1	322	-5153
TAB2	2991	1892
TACC3	4361	-4182
TAGAP	-4808	2280
TAOK1	2108	942
TAX1BP1	2377	-4470
TBL1XR1	1687	962
TCF12	-384	-4702
TCF7	-3405	2023
TCF7L2	-1653	-3431
TCIRG1	3114	-5082
TEC	3241	-5839
TERT	445	2491
TFDP1	3847	-1587
TFDP2	-4878	-4793
TGFA	4154	-3020
TGFB1	1971	-6
TGFBR1	507	-6163
TGFBR2	1344	-5224
TGIF1	-2942	-5815
TGIF2	-3529	-6609
THBS3	3035	-2835
THEM4	-4101	-6129
TIA1	-1562	-1498
TIAL1	-679	-277
TIAM2	-4202	-1035
TJP2	1474	-67
TLE2	-1787	-3959
TLE3	3950	-3798
TLE4	2883	635
TLN1	3884	191
TLR9	-1815	2292
TMED2	2437	-3656
TMED5	2957	85
TNF	-2330	-3779
TNFAIP3	-4190	-785
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFRSF10D	4239	-5911
TNFRSF1A	4337	-4958
TNFSF10	931	-2143
TNKS	-3013	-1583
TNKS2	-164	-449
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TP53	-4078	-739
TRADD	-173	-1481
TRAF1	-4528	2318
TRAF2	-4465	-1442
TRAF6	-81	-6118
TRIB3	-1812	1669
TRIM27	3711	-1744
TRIM33	-3064	-2091
TRIO	571	-5812
TRRAP	-2130	1860
TSC1	-627	1527
TSC2	-257	895
TTC21B	-4235	-4514
TULP3	-4583	-3271
TYK2	3075	-3105
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2D1	4213	-1581
UBE2D3	3969	-373
UBE2M	3295	-3585
UCHL5	-2631	-6243
UHMK1	-1162	-1644
USF1	1816	1871
USF2	2690	-624
USP13	-2115	-667
USP15	2399	686
USP21	-2098	-3841
USP34	-296	-4481
USP4	3431	-5610
USP7	2617	-2216
USP8	2599	-424
VAPA	4183	-5592
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCL	3178	-5870
VCP	2927	-2411
VEGFA	3184	-2723
VIPR1	-1885	-3480
VPS26A	2734	-287
VPS29	1052	9
VPS35	2728	-1928
VRK3	402	-1398
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WDR19	-2296	98
WDR35	-3793	-4696
WDR83	1306	840
WIPF1	182	-4382
WIPF2	2264	-2523
WNT1	-2892	-5360
WNT2B	-1182	-4534
WWOX	-4198	1732
WWP1	-3587	-1865
WWP2	3586	-718
XPO1	-371	-870
YBX1	1033	-364
YES1	-4790	-4415
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541
YY1	169	-5165
ZDHHC21	-1927	-3185
ZDHHC7	3908	-747
ZFYVE16	3367	-2416
ZFYVE9	-2531	-4766
ZNF217	1076	-5171
ZNRF3	-542	-5301
ZW10	11	160
ZWILCH	-4593	-103
ZWINT	-1433	-2742

---

---

Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases

metric	value
setSize	284
pMANOVA	8.88e-13
p.adjustMANOVA	1.42e-10
s.dist	0.255
s.RNA	0.251
s.meth	0.0417
p.RNA	4.93e-13
p.meth	0.23

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
FURIN	4236	2351
PTPRJ	3447	2365
ADAP1	3329	2385
ATP6V1A	4307	1580
ATP6V0B	3961	1604
PPP2CB	3404	1797
MAPK1	3257	1865
BRK1	3002	1970
MKNK1	3706	1538
TAB2	2991	1892
YWHAB	2609	2125
SHB	2487	2212
FOS	2486	2149
APH1B	2525	2056
RHOA	3688	1313
CBL	3300	1456
PTPN1	2276	2074
ADAM10	3964	976
RAC1	3977	971

Click HERE to show all gene set members

All member genes

	RNA	meth
AAMP	-1094	-5298
ABI1	3047	-1788
ABI2	-4058	-5451
ADAM10	3964	976
ADAM17	3540	774
ADAP1	3329	2385
ADORA2A	1055	-5935
AHCYL1	2655	-3553
AKT1	1248	-1942
AKT2	108	-141
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
APH1A	1483	-6066
APH1B	2525	2056
ARF6	431	-3567
ARHGEF7	-1390	-5507
ATF1	2271	-2565
ATP6V0A1	4395	-5877
ATP6V0A2	-4820	689
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
BAIAP2	-56	1977
BAX	2386	-3623
BRAF	406	-4347
BRK1	3002	1970
CALM1	-614	-5019
CAV1	584	-2432
CBL	3300	1456
CDC42	3265	-2719
CDK5	3942	-506
CDK5R1	-356	-2113
CHD4	-1372	-4634
CHEK1	-752	-211
CLTA	3793	-5077
CLTC	4170	2477
COL9A2	-3547	-2895
CREB1	-423	-672
CRK	4109	-4581
CRKL	1383	-906
CSK	2014	862
CTNNB1	2647	-1691
CTNND1	-2884	1566
CUL5	269	-3077
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
DIAPH1	-221	1033
DLG4	4181	-3021
DNAL4	1131	-45
DNM1	1196	-5619
DNM2	2474	738
DOCK7	-717	-5883
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
EGR1	955	-163
EGR2	-635	-2628
ELMO1	2569	-2714
ELMO2	1638	1326
EP300	2504	-4509
EPN1	3574	-2171
EPS15	1476	-654
EPS15L1	1262	-3901
ERBB2	-4860	-5145
ESRP2	-3028	-6611
FER	554	-3332
FES	4294	-6334
FGF9	-3030	1634
FGFBP3	-3186	1
FGFRL1	-4616	-2409
FLT3LG	-3269	1573
FOS	2486	2149
FOSB	441	-332
FOSL1	4094	737
FRS2	-1016	-1999
FRS3	3191	-2329
FURIN	4236	2351
FYN	-4569	1957
GAB2	3616	-6153
GALNT3	633	-2941
GGA3	1328	450
GRAP2	1747	-5763
GRB10	4408	-70
GRB2	4321	-2295
GTF2F1	1892	-1723
GTF2F2	2127	-2885
HBEGF	1808	-6428
HGS	1660	2123
HNRNPF	1377	-58
HNRNPH1	-2572	-1020
HNRNPM	2005	-4945
HRAS	-989	-4780
HSP90AA1	415	-781
HSPB1	544	-4137
ID1	1788	-3980
ID2	-4116	566
ID3	-2928	1995
IGF1R	2402	-4939
INSR	3618	-2668
IRS1	563	-4060
IRS2	3752	-5410
ITCH	429	-1366
ITGA2	1463	-3856
ITGAV	2458	-5201
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JAK2	834	-1751
JUNB	2887	-3031
JUND	480	-1239
KIDINS220	3019	189
KRAS	1294	440
LAMA2	-3513	-1315
LAMB2	156	-2207
LCK	-4404	2489
LRIG1	-3683	-3314
LYL1	3750	-6435
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K5	1370	-3572
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPKAP1	1937	1057
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MEF2D	-939	-3018
MEMO1	4052	-3910
MKNK1	3706	1538
MLST8	98	287
MST1	260	1514
MST1R	-1732	-4446
MTOR	-3531	-1813
MXD4	-4327	-2602
NAB1	407	-2731
NAB2	-3750	989
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCF4	4349	-6732
NCK1	-4400	-1408
NCK2	1874	-4310
NCKAP1L	3255	-6178
NCOR1	2375	-3738
NCSTN	4222	-3821
NEDD4	2574	-5611
NELFB	121	1822
NOS3	-515	-1770
NTRK1	-2556	898
PAG1	1436	262
PAK1	3707	-3995
PAK2	3694	-3961
PCSK5	1809	-4883
PDE3B	-4305	-4025
PDPK1	2505	167
PGF	-1749	1959
PIK3CA	1725	-1445
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R4	-1199	-3425
PLCG1	-3823	-3541
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PRKACA	4377	-6032
PRKACB	-4623	455
PRKCA	368	810
PRKCB	2983	-4518
PRKCD	4146	584
PRKCE	-2656	-5632
PRKCZ	-4414	-5220
PRR5	-4670	-1591
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PTBP1	-64	-1843
PTK2	1637	920
PTK2B	3561	40
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN12	3633	-1077
PTPN18	2351	693
PTPN2	3324	-3701
PTPN6	2483	-4586
PTPRJ	3447	2365
PTPRU	-809	1974
PXN	2575	-5712
RAB4A	3589	-5479
RAB4B	1059	1318
RAC1	3977	971
RALA	865	-262
RALB	3837	-1081
RALGDS	-4773	1254
RANBP10	823	-5295
RANBP9	2336	-1361
RAP1A	3142	323
RAP1B	1106	-1031
RAPGEF1	-3584	1868
RASA1	674	-167
REST	304	2128
RHOA	3688	1313
RICTOR	-3355	1651
RIT1	4242	337
RNF41	3835	109
ROCK1	3215	-985
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SGK1	1695	-6076
SH2B3	1357	1699
SH2D2A	-4879	2200
SH3GL1	3385	1075
SHB	2487	2212
SHC1	1469	-2954
SOCS1	1346	-2999
SOS1	-1758	-6775
SPRED1	-2940	-6227
SPRED2	2902	521
SPRY1	573	-5532
SPRY2	-1472	-5919
SRC	-3100	-4427
SRF	3082	-1284
STAM	404	770
STAM2	2488	-2181
STAT1	-4575	2195
STAT3	3649	-3606
STAT5A	2944	-6427
STAT5B	2958	-3446
STAT6	2355	-3911
STMN1	-2954	-3648
STUB1	-337	-2168
TAB2	2991	1892
TCF12	-384	-4702
TCIRG1	3114	-5082
TEC	3241	-5839
TGFA	4154	-3020
THBS3	3035	-2835
THEM4	-4101	-6129
TIA1	-1562	-1498
TIAL1	-679	-277
TLR9	-1815	2292
TRIB3	-1812	1669
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
USP8	2599	-424
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VEGFA	3184	-2723
VRK3	402	-1398
WASF1	4426	-1056
WASF2	3777	-2654
WWOX	-4198	1732
WWP1	-3587	-1865
YES1	-4790	-4415
YWHAB	2609	2125

---

---

Disease

Disease

metric	value
setSize	871
pMANOVA	1.15e-11
p.adjustMANOVA	1.6e-09
s.dist	0.141
s.RNA	0.131
s.meth	0.0529
p.RNA	1.82e-10
p.meth	0.0101

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
FURIN	4236	2351
ENTPD1	3776	2446
QKI	4113	2193
ANTXR2	3207	2471
GNG5	4068	1920
TLR5	4278	1823
ACTG1	3946	1793
MYH9	2818	2182
PPP2CB	3404	1797
MAPK1	3257	1865
BRD4	2362	2511
BRK1	3002	1970
BCL2L11	3144	1781
YWHAB	2609	2125
PPP1CB	3008	1839
PAPSS1	4158	1297
GLB1	3936	1368
PSMA7	3060	1752
PIK3CD	2436	2189

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ABCA1	2422	-6487
ABCB6	2627	-6503
ABCD4	-2847	-4648
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ACACA	2069	-164
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ACY1	-1397	-1933
ADAM10	3964	976
ADAM17	3540	774
ADAMTS10	-4023	-5260
ADAMTS13	-1254	958
ADAMTS17	-1102	463
ADAMTS6	-2140	1076
ADAMTSL4	3240	1378
ADAMTSL5	-2562	-6404
ADCY4	1985	-6389
ADCY7	-982	-5596
ADCY9	46	-2618
ADM	4381	-6151
ADORA2A	1055	-5935
ADRB2	-4638	-3531
AGGF1	2543	-3806
AGK	-4734	-3004
AGRN	-4590	-2304
AGTRAP	4129	-6548
AHCY	140	-5043
AHCYL1	2655	-3553
AKAP9	-1540	-3186
AKT1	1248	-1942
AKT1S1	3491	-2319
AKT2	108	-141
ALG11	-1076	-549
ALG12	852	-1300
ALG14	2290	1103
ALG2	-422	-625
ALG3	-387	-2680
ALG6	508	-4449
ALG8	-1089	-3591
ALG9	-3466	-1148
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC15	4157	-1379
ANAPC16	-645	-4507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
ANTXR2	3207	2471
AP1B1	3990	-463
AP1G1	1421	516
AP1M1	2828	-2408
AP1S3	-1711	-5455
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
AP3B1	3779	-3148
APBB1IP	4055	-5120
APC	1087	-4775
APH1A	1483	-6066
APH1B	2525	2056
APP	4212	-5300
ARF1	4190	-6686
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ARRB1	659	-6363
ARRB2	3858	-2243
ARSB	3173	-5722
ATG7	3598	569
ATP1A1	915	-365
ATP6V1H	3629	-1695
AXIN1	-3733	-5655
B2M	-2236	-2389
B3GALT6	-1361	2030
B3GAT3	-902	646
B4GALT1	1562	-160
B4GALT7	-2379	482
B4GAT1	-1747	451
BAD	2952	-1382
BAG4	3782	-3089
BAIAP2	-56	1977
BANF1	-1462	-709
BCL2L11	3144	1781
BCR	-2308	-6682
BECN1	2625	459
BIN2	2275	-2805
BRAF	406	-4347
BRAP	2050	-3662
BRD4	2362	2511
BRK1	3002	1970
BSG	4260	-1562
BTD	-4762	146
BTRC	-1491	-2427
C1GALT1	-1289	-3509
C1QBP	-287	-2507
C3AR1	3600	-6729
CALM1	-614	-5019
CALR	2620	-3753
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAMK4	-3176	1482
CANX	2138	-4839
CAPN1	3912	-6119
CAPN2	341	-1533
CAPNS1	3303	-2032
CASP1	1434	-1448
CASP9	3414	-234
CAST	3585	-5687
CBL	3300	1456
CBX1	1756	-1720
CCNC	596	-1138
CCND1	-2169	-6213
CCND2	-4504	-5700
CCND3	3252	905
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCNH	249	-3754
CCNK	942	-6142
CCNT1	-3342	1773
CD247	-4870	2098
CD320	-3345	103
CD4	-1631	-6372
CDC16	-1863	-4152
CDC23	-4319	-707
CDC25A	945	-1711
CDC25B	-4631	2116
CDC25C	1885	-2877
CDC42	3265	-2719
CDK2	-1524	1018
CDK4	-4195	-1295
CDK5	3942	-506
CDK5R1	-356	-2113
CDK6	-1983	-2864
CDK7	2020	275
CDK8	-597	-5509
CDK9	-1184	1524
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDKN2A	-1623	-4511
CEBPD	4041	-5142
CHMP1A	2294	2118
CHMP2A	4065	-297
CHMP2B	2237	-4000
CHMP3	3762	-2694
CHMP4A	794	458
CHMP4B	4045	-4297
CHMP5	1842	-2010
CHMP6	2172	-2539
CHMP7	-2791	-1608
CHST14	372	-6351
CHSY1	3686	-4487
CHUK	3527	1343
CLCN6	725	-775
CLTA	3793	-5077
CLTC	4170	2477
CNTRL	-2141	-6676
COMT	3713	-6677
CORO1A	1975	2237
CPSF4	-3362	134
CPSF6	-1835	2374
CRBN	-1934	919
CREB1	-423	-672
CREBBP	1169	-5804
CRK	4109	-4581
CSK	2014	862
CSNK1A1	3434	769
CTBP1	-2048	2394
CTDP1	2551	1112
CTNNB1	2647	-1691
CTNND1	-2884	1566
CTSA	4423	-4847
CTSL	1667	-6671
CUL1	-4385	-5146
CUL5	269	-3077
CUX1	4088	-2129
CXCR4	-37	-1660
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
CYP2R1	-3592	-1915
CYP2U1	-4695	-4531
CYP4F22	-4843	-2371
DAG1	-2435	-146
DAXX	-3887	-450
DBP	-4352	-1027
DCXR	-101	-2013
DDX5	-3458	1288
DERL1	-3142	123
DERL2	1003	-2287
DERL3	-2254	-2550
DHDDS	-625	-4895
DNAJC3	3833	-2353
DOLK	-1093	-2245
DPAGT1	690	650
DPEP2	-826	-6530
DPM1	488	-2366
DPM2	1768	-1939
DPM3	827	-2637
DUSP10	-486	-1469
DUSP16	-2084	-2622
DUSP6	1572	-6763
DUSP7	-965	-1322
DUT	-1868	1287
DVL1	19	-4520
DVL2	-3982	-1356
DVL3	2248	-3704
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
E2F1	2654	-1005
E2F2	4026	386
E2F3	2805	-2884
EED	-3277	-1174
EEF2	93	2127
EIF2AK2	-3267	-3645
ELL	1902	574
ELMO1	2569	-2714
ELMO2	1638	1326
ENO1	4071	-6654
ENTPD1	3776	2446
ENTPD5	-1942	-4305
EP300	2504	-4509
EPS15	1476	-654
ERBB2	-4860	-5145
ERCC2	1202	-594
ERCC3	-2537	969
ERLEC1	246	-2711
ERLIN1	4030	899
ERLIN2	4085	-4042
ESR2	-3196	-2661
ETV6	1983	-6394
EXT1	2906	-5359
EXT2	-434	-1799
EZH2	-3517	-20
F12	4416	-1719
FAU	-129	-3862
FBXW7	-2109	-5428
FDX1	607	-3747
FDXR	1779	-3448
FEN1	-3976	-56
FGF9	-3030	1634
FGFR1OP	-2152	985
FGFR1OP2	3503	-2734
FGR	3790	-5292
FIP1L1	-2679	-2274
FKBP1A	4177	-4465
FOXO1	-3171	-5036
FOXO3	3983	711
FRS2	-1016	-1999
FURIN	4236	2351
FXR1	2066	-1166
FYN	-4569	1957
FZD5	4425	-2513
FZD6	-1991	-6235
FZD7	-2029	-3834
FZD8	-2326	-6560
FZR1	-666	-758
G6PC3	1369	-6318
GAA	3578	-3801
GAB2	3616	-6153
GALE	1941	-105
GALK1	4095	-2705
GALNS	3068	-854
GALNT12	-3462	-5876
GALNT3	633	-2941
GALT	-3046	-325
GANAB	-316	-3501
GCLC	-4576	-1829
GCLM	2152	-248
GFPT1	-2050	-2828
GGCX	2025	-3236
GGT1	4400	-6607
GIPR	-4760	-2380
GLB1	3936	1368
GNAI2	3614	-1747
GNAI3	3575	-909
GNAS	3567	951
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNE	-1601	-4921
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GNS	4312	-571
GOLGA2	2510	1847
GOLGA4	-1210	-155
GPC2	-1070	-6477
GPS2	-290	-857
GRB2	4321	-2295
GRSF1	1991	27
GSK3A	3432	-2192
GSK3B	2793	736
GSS	221	-1739
GTF2A1	884	271
GTF2A2	3083	-1036
GTF2B	1223	-3218
GTF2E2	2305	-184
GTF2F1	1892	-1723
GTF2F2	2127	-2885
GTF2H3	-664	1025
GTF2H4	-874	-2761
GTF2H5	1343	691
GUSB	3221	-4967
GYG1	4223	-5541
GYS1	3086	-1092
HBEGF	1808	-6428
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HEXA	397	-4273
HEXB	3996	-5777
HEY2	-3510	2330
HGS	1660	2123
HGSNAT	591	2126
HHAT	-3114	-5389
HK1	4140	479
HLA-A	-768	-5991
HLCS	-4574	1551
HMGA1	24	802
HNRNPK	3313	-2386
HRAS	-989	-4780
HRH2	4409	-6490
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSPA1A	3666	-3825
HYAL1	1530	-6777
IDH1	4421	-2333
IDUA	-1786	932
IKBKB	-1620	-3894
IL1RAP	3160	-456
IL6R	3697	-6410
IMPDH1	4348	-750
IMPDH2	-3359	446
IPO5	-3937	1869
IQGAP1	3672	1271
IRS1	563	-4060
IRS2	3752	-5410
ISG15	-4761	1894
ITGA4	-4108	1419
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JAK1	-4154	-1022
JAK2	834	-1751
JUN	1372	69
KANK1	-1164	-270
KAT2A	-3767	-5050
KAT2B	-704	-1588
KCNJ11	-1204	-2105
KHK	-2302	-1547
KPNA1	409	-2889
KPNA2	-2167	-874
KPNA3	308	-897
KPNA4	1912	1716
KPNA5	-4625	-572
KPNB1	799	-2176
KRAS	1294	440
KSR1	1447	2466
LCK	-4404	2489
LFNG	-2876	1932
LIG1	-3821	-4259
LIG4	2068	-949
LMBRD1	2726	-156
LMNA	1334	-6474
LMNB1	4362	-942
LRP5	1500	1949
LRP6	252	-4544
LRRFIP1	2455	-1040
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAN1B1	-1489	2249
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K11	3368	-2732
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK8	-3380	6
MAPKAP1	1937	1057
MARK3	4010	-3461
MCCC1	-3158	-4716
MCCC2	-4621	1857
MDM2	1471	-1318
MGAT1	2494	1169
MGAT2	519	-1666
MIB1	-895	-2718
MLST8	98	287
MMAA	-4458	-3965
MMAB	-3148	-850
MMACHC	-2095	-266
MMADHC	2634	-3748
MNAT1	-3019	311
MOGS	-919	-2356
MPDU1	3420	-1260
MPI	-3671	-5890
MPRIP	-3919	755
MSH2	-4317	83
MSH3	2316	-924
MSH6	-655	1672
MTOR	-3531	-1813
MTR	-4637	448
MTRR	634	-694
MUC1	2718	-5557
MUC12	-4050	-5807
MUC5B	-1387	2353
MUTYH	-4039	-2996
MVB12A	3203	272
MYD88	3613	-1927
MYH9	2818	2182
MYO18A	-1170	-6701
MYO9B	2658	687
NAGLU	-1458	-5716
NAPEPLD	-2226	-4964
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCK1	-4400	-1408
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NCOR1	2375	-3738
NCOR2	3521	-4281
NCSTN	4222	-3821
NDC1	-4771	-5228
NEDD4L	3534	-5066
NEIL3	416	248
NELFA	-1150	35
NELFB	121	1822
NELFCD	-1955	2444
NELFE	1359	1377
NEU1	4191	-3878
NF1	1012	-2145
NFKB2	-279	388
NFKBIA	2855	1159
NHLRC1	-1718	-5836
NLRP3	4033	-6357
NMT1	1591	-3001
NMT2	-4662	1340
NOTCH1	1739	1722
NOTCH4	-1578	-6455
NOXA1	-1687	-5872
NR3C1	190	-2420
NR4A1	-2135	657
NTHL1	-2708	-5795
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
NUS1	3489	-9
OGG1	-2610	-3033
OS9	4053	-975
P2RX4	3391	174
PABPN1	-170	-3743
PACS1	-2828	-4252
PAK2	3694	-3961
PAPSS1	4158	1297
PARP1	-4461	-5521
PARP10	-2831	2302
PARP14	-4650	864
PARP16	-4459	678
PARP4	1531	-715
PARP6	-1500	-3268
PARP8	-2888	-759
PARP9	-1402	1117
PC	4322	-5175
PCCB	-2665	-6219
PDCD6IP	2715	-3917
PDPK1	2505	167
PEBP1	-4273	-152
PGM1	2353	-4799
PHB	-914	-3178
PIK3AP1	3450	-4753
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R4	-1199	-3425
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLK2	-832	-6257
PML	-3036	549
PMM2	439	-2687
PMS2	-1709	1574
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POM121	-2762	-1787
POM121C	-2356	-4315
POMGNT1	-4641	-826
POMT1	-2923	1390
POMT2	195	-669
PPIA	-2188	490
PPP1CB	3008	1839
PPP1CC	2576	-754
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5A	2378	381
PPP2R5B	2877	-6343
PPP2R5C	-4356	2376
PPP2R5D	777	-4349
PPP2R5E	-200	-2288
PRDX1	3015	-877
PRDX2	1172	-5158
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PRKCSH	2022	-3007
PRR5	-4670	-1591
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PSIP1	-3456	-4249
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PSTPIP1	3510	1135
PTEN	3857	-1100
PTGER2	447	-5853
PTGER4	-4573	1153
PTK2	1637	920
PTPN11	2065	-2302
PTPN12	3633	-1077
PYCARD	3986	-6598
QKI	4113	2193
RAB5A	3055	-1686
RAB7A	4011	-5570
RAC1	3977	971
RAC2	1994	-868
RAE1	1948	-39
RAF1	3548	-314
RAN	-2179	1257
RANBP1	-3483	-2212
RANBP2	-259	-4704
RANGAP1	-4514	1644
RAP1A	3142	323
RAP1B	1106	-1031
RB1	3934	-4740
RBBP4	-573	-3282
RBPJ	3993	-1118
RBX1	1413	-3241
RCC1	531	-1845
RELA	-541	2085
RFT1	1565	147
RHBDF2	1487	-4959
RHOG	3876	860
RICTOR	-3355	1651
RNF185	2714	-2775
RNF213	-4661	2228
RNF5	-2030	-4625
RNGTT	976	-2952
RNMT	-4236	2172
ROCK1	3215	-985
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS6KB2	209	1145
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
S1PR1	-3197	2436
SDC4	2765	1193
SEC13	2286	-3749
SEH1L	-1833	-1615
SEL1L	2854	-2307
SFPQ	733	-1117
SH3GL1	3385	1075
SHC1	1469	-2954
SHOC2	3168	-3532
SIGMAR1	-2520	306
SIN3A	-3920	-4151
SKP1	1561	-2290
SKP2	-2780	-1566
SLC11A2	74	-4073
SLC12A6	3687	-2521
SLC16A1	1645	576
SLC17A5	1920	-3631
SLC20A2	-4611	-345
SLC22A5	2964	-5659
SLC24A4	3374	-6556
SLC25A4	-4546	-2062
SLC26A2	-879	-2627
SLC27A4	810	-6752
SLC29A3	2000	2162
SLC2A1	-4290	1930
SLC2A9	2858	-6223
SLC33A1	-643	-2395
SLC35A1	3137	-4021
SLC35A3	-3325	-4409
SLC35C1	881	-5366
SLC35D1	-2160	-2789
SLC37A4	-1887	-3038
SLC39A4	1646	494
SLC3A2	1969	-1667
SLC5A5	-1629	-5772
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SND1	1354	-1905
SNF8	2382	-2157
SNW1	2003	946
SOD2	1617	573
SOS1	-1758	-6775
SPON2	-4845	1081
SPRED1	-2940	-6227
SPRED2	2902	521
SPRED3	-2225	-4087
SRC	-3100	-4427
SRD5A3	1437	442
SSRP1	-4239	-2441
ST3GAL1	-2411	1767
ST3GAL2	4018	-2686
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST6GAL1	-4644	1948
ST6GALNAC3	4287	145
ST6GALNAC4	-268	-5981
STAM	404	770
STAM2	2488	-2181
STAT1	-4575	2195
STAT3	3649	-3606
STAT5A	2944	-6427
STAT5B	2958	-3446
STRN	1292	1051
STX1A	-1208	-2461
STX1B	-888	-6167
SUGT1	483	594
SUMO1	2937	-3986
SUPT16H	-4379	-3702
SUPT4H1	966	-1899
SUPT5H	-2124	-3641
SYK	4194	-5054
SYVN1	322	-5153
TAF10	3073	1606
TAF11	-873	-719
TAF12	3604	-1765
TAF13	3147	-908
TAF15	-2044	-3109
TAF2	-1849	-4149
TAF3	-546	-3002
TAF4	-518	-6161
TAF4B	-2590	-1647
TAF5	-1331	1150
TAF6	-2393	1804
TAF7	625	-3426
TAF9	390	1714
TALDO1	4405	-5245
TBK1	1029	-4616
TBL1XR1	1687	962
TBXAS1	3948	-6709
TCEA1	-301	-4211
TCF7L2	-1653	-3431
TFDP1	3847	-1587
TFDP2	-4878	-4793
TGFA	4154	-3020
TGFB1	1971	-6
TGFBR1	507	-6163
TGFBR2	1344	-5224
TICAM1	2598	-2136
TIRAP	2227	-5182
TLN1	3884	191
TLR1	4160	-6127
TLR2	4180	-6586
TLR3	-4429	-5820
TLR5	4278	1823
TLR6	4103	-802
TLR9	-1815	2292
TNKS	-3013	-1583
TNKS2	-164	-449
TPMT	1593	-5097
TPR	-2272	-973
TPST1	4354	-2233
TPST2	2313	-2387
TRAF3	-1622	2379
TRIM24	1316	-5752
TRIM27	3711	-1744
TRIM28	-1482	1191
TSC2	-257	895
TSG101	3465	-5032
TUBB	-2260	1395
TXN	3798	284
TXNIP	-3453	-2777
TXNRD1	3738	-4647
TYK2	3075	-3105
UBA52	344	752
UBAP1	4015	-2481
UBB	2801	-1321
UBC	1599	-2568
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2E1	2865	-5882
UBE2I	-239	233
UBE2S	1785	2449
UNC93B1	1454	-4358
UVRAG	-3183	-3344
VAMP1	-2507	-1537
VAMP2	-4530	-2770
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCL	3178	-5870
VCP	2927	-2411
VEGFA	3184	-2723
VHL	1285	1389
VIPR1	-1885	-3480
VPS25	3359	1235
VPS28	1503	-2471
VPS33B	-598	-2464
VPS36	-2208	-2008
VPS37A	2702	-3512
VPS37B	1362	-6110
VPS37C	3535	421
VPS4A	247	118
VTA1	2518	-3898
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WDR48	-4493	-5481
WIPF1	182	-4382
WIPF2	2264	-2523
XPO1	-371	-870
XRCC4	2832	-3706
XRCC5	2099	-3770
XRCC6	-1338	376
YES1	-4790	-4415
YWHAB	2609	2125
YWHAE	4144	-4168
ZC3HAV1	-3677	1635
ZCRB1	219	2291
ZFYVE9	-2531	-4766
ZMYM2	1138	-896

---

---

Metabolism of proteins

Metabolism of proteins

metric	value
setSize	1263
pMANOVA	1.28e-11
p.adjustMANOVA	1.6e-09
s.dist	0.119
s.RNA	0.0978
s.meth	0.0672
p.RNA	2.11e-08
p.meth	0.00012

Top 20 genes

Gene	RNA	meth
FURIN	4236	2351
MSRB1	4338	2285
SOCS3	4414	2178
SIAH2	3939	2185
GNG5	4068	1920
PHC2	4201	1830
KDELR1	4237	1780
CTSD	4393	1642
MSRA	3229	2208
FKBP8	3962	1784
RNF146	3919	1789
RNF123	2894	2363
TMED7	3495	1939
CCT5	3103	2091
CUL3	2907	2054
TUBB4B	3154	1856
DAD1	2384	2452
PPP6C	2885	2020
NOD2	3786	1528
GLB1	3936	1368

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
AARS2	-4481	-3118
ACTB	4172	-4515
ACTL6A	-2395	-4851
ACTR10	3334	-1291
ACTR1A	3003	-1
ACTR5	-4180	-3829
ACTR8	-1484	-5628
ADAM10	3964	976
ADAMTS10	-4023	-5260
ADAMTS13	-1254	958
ADAMTS17	-1102	463
ADAMTS6	-2140	1076
ADAMTSL4	3240	1378
ADAMTSL5	-2562	-6404
ADD1	2270	-89
ADORA2A	1055	-5935
ADRB2	-4638	-3531
ADRM1	1393	589
AGBL2	-3088	-5272
AGBL3	-2956	-646
AGBL5	1159	-3128
AGTPBP1	3771	-1941
AIMP2	-288	-4973
ALG10	-2612	-346
ALG10B	-2684	966
ALG11	-1076	-549
ALG12	852	-1300
ALG14	2290	1103
ALG2	-422	-625
ALG3	-387	-2680
ALG5	-216	-2175
ALG6	508	-4449
ALG8	-1089	-3591
ALG9	-3466	-1148
AMDHD2	-3916	539
AMFR	3220	-6742
ANK1	4083	-4221
ANK3	-1508	-6563
ANKRD28	-1964	-5108
ANKRD9	3685	-635
ANO8	2476	384
AP3M1	2146	-808
APC	1087	-4775
APEH	342	1724
APH1A	1483	-6066
APH1B	2525	2056
APLP2	4302	-3465
APP	4212	-5300
ARCN1	2206	-1676
ARF1	4190	-6686
ARF3	3423	-1912
ARF4	4255	-3280
ARF5	3536	-4789
ARFGAP1	-583	1688
ARFGAP3	1308	-5386
ARFGEF2	-1276	-5016
ARL2	-203	-4526
ARRB1	659	-6363
ARRB2	3858	-2243
ARSA	1185	-3099
ARSB	3173	-5722
ARSG	-1451	152
ARSK	-4241	-54
ASB1	1098	1900
ASB13	1125	-5265
ASB2	-4713	-2230
ASB6	-835	-6098
ASB7	2567	-4653
ASB8	1852	998
ASNS	-2777	12
ASXL1	-3667	-4360
ASXL2	585	-1790
ATF3	-3533	-4121
ATF4	2565	-956
ATF6	3830	-4952
ATP6V0D1	4304	-1003
ATXN3	502	1703
ATXN7	-505	759
AURKA	1188	-385
AURKAIP1	2459	-3441
AURKB	309	-889
AXIN1	-3733	-5655
AXIN2	-2404	-4719
B2M	-2236	-2389
B3GALNT2	-5	-1560
B3GNT2	2380	-1684
B3GNT7	-4852	-6593
B3GNT8	4186	-6681
B3GNTL1	2141	-2656
B4GALT1	1562	-160
B4GALT2	-1893	1307
B4GALT3	-3906	-4680
B4GALT4	185	-1422
B4GALT5	4092	52
B4GALT6	-3085	-6484
B4GAT1	-1747	451
BABAM1	-297	-1937
BAP1	357	1999
BARD1	-1018	-2910
BCL10	2346	-3261
BECN1	2625	459
BET1	-202	-4482
BET1L	-2386	332
BIRC2	1750	-1862
BIRC3	-4025	-2320
BIRC5	1432	-84
BLM	-1434	-2909
BMI1	-3450	-6383
BRCA1	2537	-4609
BTBD1	718	-5321
BTBD6	-1611	-136
BTRC	-1491	-2427
C1GALT1	-1289	-3509
CALM1	-614	-5019
CALR	2620	-3753
CALU	3485	1252
CAND1	-2049	-421
CANX	2138	-4839
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CARS2	3119	-1826
CASP8AP2	-3731	231
CBX4	706	-5288
CBX8	2136	2207
CCDC59	-1166	-1734
CCNA2	521	-1132
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCNF	-3306	-4258
CCT2	-2968	-727
CCT3	-740	-3438
CCT5	3103	2091
CCT6A	-204	1098
CCT7	-949	243
CCT8	2742	-1245
CD55	4233	-3923
CD59	2365	-6024
CDC20	1435	116
CDC25A	945	-1711
CDC34	3982	-2454
CDC73	1921	-2092
CDCA8	-556	472
CDK1	454	-4215
CDKN2A	-1623	-4511
CEBPB	3621	-5089
CEBPG	2149	1702
CHCHD1	3099	757
CHD3	-3299	422
CHST10	-4624	-5927
CISH	1861	1748
CKAP4	4371	-6717
CLSPN	1301	-1524
CMAS	4029	-2712
CNIH1	3446	-6699
COG1	-4741	-3663
COG2	-2655	-6132
COG3	-1593	-5701
COG4	1	-984
COG5	-985	-1864
COG6	-1803	-358
COG7	1546	-4196
COG8	-131	1846
COMMD1	2360	-4720
COMMD10	1547	171
COMMD2	1077	782
COMMD3	-436	-6772
COMMD4	-1392	-5750
COMMD5	2159	-1140
COMMD6	-350	-2702
COMMD7	2028	2040
COMMD8	3189	187
COMMD9	3497	-4811
COPA	3748	1056
COPB1	3188	-1329
COPB2	3530	-1501
COPE	2941	213
COPS2	2465	896
COPS3	2406	-2950
COPS4	587	-3507
COPS5	1597	-1617
COPS6	516	-866
COPS7A	2748	-565
COPS7B	-3523	538
COPS8	-3027	-4126
COPZ1	1431	-5051
COPZ2	-4133	1305
CPM	2884	-4667
CREB3	-1252	-1896
CREB3L2	-353	-4035
CREB3L4	-3507	-6715
CREBBP	1169	-5804
CREBRF	-68	1873
CSF1	-605	-5924
CSNK1D	771	-1777
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CTBP1	-2048	2394
CTDSP2	2189	-5429
CTNNB1	2647	-1691
CTR9	1123	-5535
CTSA	4423	-4847
CTSC	817	1561
CTSD	4393	1642
CTSZ	4137	-6765
CUL1	-4385	-5146
CUL2	821	-1212
CUL3	2907	2054
CUL4A	-1453	1876
CUL5	269	-3077
CUL7	-1000	-2524
CUL9	-1822	-5978
CXXC1	-649	-2019
CYLD	-3106	1406
DAD1	2384	2452
DAG1	-2435	-146
DAP3	-403	-5114
DARS2	-1060	-124
DAXX	-3887	-450
DCAF10	1871	1341
DCAF11	-733	-1493
DCAF13	-1724	-2001
DCAF16	-4513	-4367
DCAF17	-4276	986
DCAF4	-4183	1739
DCAF5	-3478	-3273
DCAF6	3765	-2743
DCAF7	-500	683
DCAF8	-3470	-439
DCP2	2839	-2783
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DCUN1D2	-1465	318
DCUN1D3	1573	-429
DCUN1D4	-3492	-2024
DCUN1D5	280	-5390
DDA1	1040	606
DDB2	-4468	-561
DDIT3	1835	-3177
DDX11	-1843	-280
DDX17	-1811	206
DDX5	-3458	1288
DDX58	-4687	-1002
DERL1	-3142	123
DERL2	1003	-2287
DHDDS	-625	-4895
DHPS	160	-149
DIS3	-1302	-762
DNAJB11	2249	-137
DNAJC24	-3992	1293
DNAJC3	3833	-2353
DNMT1	-4819	1294
DNMT3A	-845	-6002
DNMT3B	1560	1185
DOHH	-508	-1316
DOLK	-1093	-2245
DOLPP1	930	-914
DPAGT1	690	650
DPH1	-4309	-3723
DPH2	-3898	-486
DPH3	3453	-3670
DPH5	38	1156
DPH7	-3935	-5720
DPM1	488	-2366
DPM2	1768	-1939
DPM3	827	-2637
DPP4	-2214	1454
DTL	123	-5529
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
EARS2	-4685	432
EDEM1	-41	1523
EDEM2	4014	-3093
EEF1A1	-1543	720
EEF1B2	-1279	1717
EEF1D	-269	-885
EEF1E1	-639	-1336
EEF1G	-443	-5880
EEF2	93	2127
EEF2KMT	-3526	2078
EID3	-4544	-328
EIF2AK3	-3831	-4333
EIF2B1	-137	-1150
EIF2B2	1091	-5304
EIF2B3	-2794	-2801
EIF2B4	877	-2442
EIF2B5	-3445	-1231
EIF2S1	1555	-4266
EIF2S2	2502	-783
EIF3A	676	1105
EIF3B	-2719	-1701
EIF3E	608	-2682
EIF3F	298	-169
EIF3G	282	1494
EIF3H	1780	1594
EIF3I	1757	-4154
EIF3J	610	-1483
EIF3K	466	1339
EIF3L	831	-4732
EIF3M	1692	887
EIF4A1	3272	-3762
EIF4A2	-4065	836
EIF4B	387	-4336
EIF4E	1815	1536
EIF4EBP1	2454	150
EIF4G1	3607	746
EIF4H	3415	-6751
EIF5	693	-1907
EIF5A	181	-363
EIF5B	-1403	705
ENGASE	-2201	-5741
EP300	2504	-4509
EPAS1	3555	535
ERAL1	-1412	-1779
ERCC8	1053	-5536
ERN1	-3290	2194
ERO1A	4059	-4535
ERO1B	-3967	-6067
ETF1	3196	758
ETFB	3405	-3921
EXOC1	2235	-2298
EXOC2	-2543	1713
EXOC3	1758	-3415
EXOC4	2207	-3655
EXOC5	1473	1408
EXOC6	4057	-5526
EXOC7	1867	-4686
EXOC8	-8	2121
EXOSC1	-309	-290
EXOSC2	-4042	1269
EXOSC3	153	-2555
EXOSC4	3412	-4410
EXOSC5	-1316	1591
EXOSC6	-3569	545
EXOSC7	-3984	-4665
EXOSC8	-4307	1020
EXTL2	-4188	-4800
EXTL3	2204	-922
FARS2	-3104	2295
FARSA	595	-5635
FARSB	-2823	1228
FAU	-129	-3862
FBXL12	-400	292
FBXL14	-1870	2358
FBXL15	1650	-4502
FBXL16	-2110	-4011
FBXL18	1128	-5248
FBXL19	3985	-6239
FBXL20	1825	-993
FBXL22	-3236	562
FBXL3	329	-4101
FBXL4	2160	-5130
FBXL5	4384	-6189
FBXL8	1405	-479
FBXO11	2807	-500
FBXO15	-347	647
FBXO21	-4031	-933
FBXO22	-1110	1132
FBXO30	1752	-609
FBXO31	-4648	480
FBXO32	-4006	-1875
FBXO4	-4627	-4056
FBXO6	-687	234
FBXO7	3287	-3059
FBXO9	4390	-3674
FBXW11	2542	-6747
FBXW2	2739	-3711
FBXW4	-4464	1993
FBXW5	75	-194
FBXW7	-2109	-5428
FBXW8	-3566	-2504
FEM1A	603	-82
FEM1B	1628	1880
FKBP14	-2972	1330
FKBP8	3962	1784
FN3KRP	-4248	1195
FOXK1	-1549	-5199
FOXK2	1134	-6253
FPGT	3174	-2826
FSTL3	4347	88
FUCA1	3251	-5579
FUCA2	3675	-427
FUOM	-1587	-5803
FURIN	4236	2351
FUT8	-3435	-2455
GADD45GIP1	526	-3607
GALNT10	-956	-6074
GALNT11	-943	-3318
GALNT12	-3462	-5876
GALNT2	4082	-5164
GALNT3	633	-2941
GALNT4	3071	-180
GALNT6	-254	-6156
GALNT7	3747	57
GAN	-427	-2479
GANAB	-316	-3501
GATA3	-4787	1861
GBA	4159	-5623
GBF1	-1292	-120
GCNT1	3825	179
GFM1	-1630	-2991
GFM2	1368	-5140
GFPT1	-2050	-2828
GGA1	745	-3812
GGA2	-2039	-3081
GGA3	1328	450
GGCX	2025	-3236
GLB1	3936	1368
GMDS	1860	-1375
GMPPA	1360	-4201
GMPPB	-2292	1238
GNAI2	3614	-1747
GNAI3	3575	-909
GNAT1	278	-1680
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNE	-1601	-4921
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GNPNAT1	-3357	-2849
GOLGA2	2510	1847
GOLGB1	-1656	-3196
GOLM1	-2215	-6094
GORASP1	2763	-2178
GOSR1	-51	-3152
GOSR2	-462	1643
GPAA1	2425	-843
GPS1	-1373	-6247
GSK3A	3432	-2192
GSPT1	2706	-4456
HARS2	-2519	-2407
HDAC1	124	-1016
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC7	2424	-4900
HDGF	3120	-3978
HERPUD1	2994	-1806
HGS	1660	2123
HIF1A	3192	-3349
HIPK2	2508	-1520
HLA-A	-768	-5991
HLA-B	212	1015
HNRNPC	2584	-1112
HNRNPK	3313	-2386
HSP90B1	655	-1371
HYOU1	-32	-3315
IARS2	2321	-844
ICMT	-247	-71
IDE	2999	-777
IFIH1	-4410	-4856
IGFBP4	-2521	-6569
IGFBP6	844	-6762
IKBKE	1764	2086
INCENP	-1866	-2850
ING2	1592	-2115
INO80	-2992	-74
INO80B	-595	-3700
INO80C	2539	-3246
INO80D	-1596	-869
INO80E	-2468	-2832
ITM2B	2407	-3556
JOSD1	94	-3051
JOSD2	3573	-957
KAT2A	-3767	-5050
KAT2B	-704	-1588
KBTBD6	-1069	327
KBTBD7	2705	-1326
KBTBD8	-1256	-4094
KCTD6	1605	886
KCTD7	-4104	-602
KDELR1	4237	1780
KDELR2	3293	-2980
KDM1B	1845	1468
KEAP1	1872	-2872
KHSRP	873	-5005
KIF5B	3643	-3520
KIN	1226	617
KLHDC3	1602	2058
KLHL11	-1896	186
KLHL2	4277	-4276
KLHL20	-4411	-2781
KLHL21	1908	-1243
KLHL22	-4140	-899
KLHL25	-3758	-464
KLHL5	1950	-4208
KTN1	1101	-2404
L3MBTL2	-3980	-4114
LAMB2	156	-2207
LARS2	-2843	-1472
LEO1	26	791
LGALS1	4174	-79
LMAN1	-3951	596
LMAN2	3064	-2497
LMAN2L	2953	-1590
LMNA	1334	-6474
LMO7	-3257	2419
LONP2	-1767	372
LRR1	-2547	1362
LRRC41	3306	404
LTBP1	3553	-4651
LYPD3	-2352	-4231
MAN1A1	3539	-447
MAN1A2	-601	-1465
MAN1B1	-1489	2249
MAN1C1	-2013	-1205
MAN2A1	-406	-4486
MAN2A2	2762	-5172
MANEA	-207	172
MAP3K7	780	-2089
MARS2	-4197	-2209
MAT2B	-3867	-2153
MAVS	3095	-4500
MBD1	632	-1177
MBD5	845	-6395
MBD6	3372	-5542
MBTPS1	951	-398
MCFD2	3037	-158
MCRS1	-2811	1266
MDC1	-4696	-902
MDM2	1471	-1318
MDM4	-377	-2440
MEN1	-2763	-2311
METTL21A	1211	1437
METTL22	1981	2176
MFGE8	1274	-527
MGAT1	2494	1169
MGAT2	519	-1666
MGAT4A	-1692	-2254
MGAT4B	3991	-6439
MGAT5	-941	-5572
MIA3	-1970	-3428
MLEC	742	953
MOGS	-919	-2356
MPDU1	3420	-1260
MPI	-3671	-5890
MRPL1	-1768	786
MRPL10	-2792	-6144
MRPL11	-1207	-4005
MRPL12	797	-4827
MRPL13	1051	-1113
MRPL14	-806	-5202
MRPL15	428	1654
MRPL16	645	-5949
MRPL18	678	-1383
MRPL19	142	-3772
MRPL2	-2382	-3200
MRPL20	-141	1926
MRPL21	272	-3387
MRPL22	565	-3797
MRPL23	3009	-2397
MRPL24	-2006	-3055
MRPL27	-931	-509
MRPL30	2082	-2103
MRPL32	-3110	-1085
MRPL33	3014	-4150
MRPL34	-335	-590
MRPL35	-1368	84
MRPL36	635	-3325
MRPL37	1078	-5276
MRPL38	-2042	-5235
MRPL39	-3905	-569
MRPL4	-571	-978
MRPL41	-414	-991
MRPL42	-2429	-66
MRPL43	-762	-795
MRPL44	1694	-5339
MRPL45	883	2443
MRPL46	-2981	-3823
MRPL47	1459	-580
MRPL48	-839	674
MRPL49	-3398	-2018
MRPL50	-2807	-1736
MRPL51	1824	-831
MRPL52	1272	-1650
MRPL53	2417	-1402
MRPL54	-606	-1702
MRPL55	-1797	-2067
MRPL57	-478	-2446
MRPL9	-4012	-6623
MRPS10	1817	-935
MRPS11	440	-697
MRPS12	-1109	162
MRPS14	-1441	-2698
MRPS15	487	-5176
MRPS16	1639	-1310
MRPS17	-1743	-3243
MRPS18A	224	-5497
MRPS18B	-3998	1727
MRPS18C	57	-2170
MRPS2	-2181	-5148
MRPS21	-2997	-3126
MRPS22	578	-4788
MRPS23	528	-5899
MRPS24	895	-1344
MRPS25	-3399	-2529
MRPS26	-1941	-3032
MRPS27	-3080	629
MRPS28	448	-928
MRPS30	-2804	-4051
MRPS31	-1509	-157
MRPS33	-3339	-276
MRPS34	1303	-1631
MRPS35	933	-1521
MRPS36	3109	-1198
MRPS5	1827	-1972
MRPS6	-4168	-3712
MRPS7	870	204
MRPS9	-4258	-5197
MSRA	3229	2208
MSRB1	4338	2285
MSRB2	4231	-5138
MTFMT	1197	-1706
MTIF2	-245	-3124
MTIF3	910	-4313
MTRF1L	1960	212
MUC1	2718	-5557
MUC12	-4050	-5807
MUC5B	-1387	2353
MUL1	997	-3003
MVD	-1820	1954
MYSM1	-2408	-616
N6AMT1	-3939	1363
NAE1	-4047	897
NAGK	1045	-5552
NANP	-3397	-585
NANS	3512	529
NAPA	425	-4125
NAPB	-827	471
NAPG	1477	-97
NAPSA	-1253	-5003
NARS2	-3001	-2538
NCOA2	352	1407
NCOR2	3521	-4281
NCSTN	4222	-3821
NDC1	-4771	-5228
NEDD8	2723	-1600
NEGR1	461	-6424
NEU1	4191	-3878
NEU3	-1129	-1409
NEURL2	-951	2421
NFKB2	-279	388
NFKBIA	2855	1159
NFRKB	-821	-3238
NFYA	1190	1464
NFYB	-3535	-531
NFYC	3381	-3078
NGLY1	-1111	-236
NICN1	-560	-2869
NLRP3	4033	-6357
NOD1	-4838	-5170
NOD2	3786	1528
NOP56	-4412	-523
NOP58	-3586	-2406
NPL	4422	-6573
NR1H2	3254	-1471
NR1H3	-1011	-2305
NR1I2	-1260	-4903
NR2C1	-3442	-1463
NR3C1	190	-2420
NR3C2	-3730	324
NR4A2	-494	1416
NSMCE1	2411	2210
NSMCE2	2356	-6425
NSMCE4A	-4080	-4495
NTNG2	2209	903
NUB1	-4715	1450
NUCB1	4098	-5498
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
NUS1	3489	-9
OS9	4053	-975
OTUB1	435	-5956
OTUD3	-3909	-1582
OTUD7B	-4748	-2644
OTULIN	-222	1535
OXA1L	2195	-3864
P2RY2	2358	-5187
P4HB	3824	-1549
PABPC1	2073	-2769
PAF1	1195	-5838
PARK7	2668	-821
PARN	-1590	-4138
PARP1	-4461	-5521
PARS2	-2074	-907
PCMT1	4044	-1554
PCNA	-1864	-511
PDCL	-411	-1308
PDIA3	1468	1466
PDIA5	3330	-5942
PDIA6	2350	1837
PEX10	-2097	1348
PEX12	-2964	-2164
PEX13	183	-1839
PEX14	1057	-3892
PEX2	988	-5892
PEX5	1499	-6491
PFDN1	1271	-1084
PFDN2	353	-3571
PFDN4	381	-3065
PFDN5	1279	-5178
PGAP1	-2996	-660
PGM3	-250	1964
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
PIAS1	3206	-2534
PIAS2	-2497	-2314
PIAS3	-401	1855
PIAS4	1999	-3982
PIGC	-452	-2121
PIGF	2774	-1570
PIGH	-3288	-1358
PIGK	-1872	-2040
PIGL	-4531	-1793
PIGM	21	-4141
PIGN	581	-3172
PIGO	-3071	-2601
PIGP	-1561	-3043
PIGQ	545	-2760
PIGS	2975	-749
PIGT	320	-1299
PIGU	-3180	-504
PIGV	-538	-2037
PIGW	-4510	1896
PIGX	2109	-5421
PLAUR	3843	-6237
PML	-3036	549
PMM1	1492	-1060
PMM2	439	-2687
PNPLA2	4155	-5698
POFUT2	-3932	1983
POLB	-2514	-1516
POM121	-2762	-1787
POM121C	-2356	-4315
POMGNT1	-4641	-826
POMGNT2	-1228	-6177
POMK	-580	-1346
POMT1	-2923	1390
POMT2	195	-669
PPA1	618	1448
PPA2	695	-5450
PPP2R5B	2877	-6343
PPP6C	2885	2020
PPP6R1	2037	-1276
PPP6R3	1102	-3726
PRKCSH	2022	-3007
PRKDC	-3663	1316
PRMT3	535	-372
PSENEN	2293	-3620
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTCD3	-3713	-1512
PTEN	3857	-1100
PTP4A2	860	2110
PTRH2	1710	-4375
PUM2	-610	-801
QSOX1	4308	-1087
RAB10	4097	-3437
RAB11A	3974	-2965
RAB11B	1610	-387
RAB12	-282	-1635
RAB14	3005	1334
RAB18	3484	-1995
RAB19	1584	-3370
RAB1A	4185	-1703
RAB1B	3794	-264
RAB22A	-1259	-3947
RAB23	361	-2847
RAB24	2077	-3725
RAB26	-1325	2425
RAB27A	3850	-1181
RAB29	-3770	282
RAB2A	3902	-2810
RAB2B	-3146	-557
RAB30	-3074	-2803
RAB33B	3182	547
RAB34	3792	-3968
RAB35	1406	780
RAB37	-4598	-5384
RAB3A	3705	-1080
RAB3D	4269	-6515
RAB40B	-4316	1177
RAB40C	3744	8
RAB43	2675	1154
RAB4A	3589	-5479
RAB4B	1059	1318
RAB5A	3055	-1686
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAB8A	1340	-1289
RAB8B	2729	79
RABGGTA	-728	1696
RABGGTB	-1598	2306
RAD18	-4589	812
RAD21	534	702
RAD23A	2724	-3621
RAD23B	4100	-3906
RAD52	-321	-2399
RAE1	1948	-39
RANBP2	-259	-4704
RANGAP1	-4514	1644
RARA	2591	-5249
RARS2	-217	-1305
RBBP5	325	-779
RBX1	1413	-3241
RCE1	-1411	-282
RCN1	-4073	-2128
RECK	-2783	-4325
RELA	-541	2085
RFT1	1565	147
RHOA	3688	1313
RHOT1	4331	-5271
RING1	-1202	-1490
RNF103	-1377	-2036
RNF123	2894	2363
RNF135	3870	-6458
RNF139	866	354
RNF146	3919	1789
RNF152	1025	-1925
RNF168	-1270	1626
RNF181	2435	312
RNF185	2714	-2775
RNF2	1210	-1936
RNF20	2282	-799
RNF40	2784	-5137
RNF5	-2030	-4625
RNF7	3537	-1943
RORA	-4632	2287
RPA1	-4680	-2495
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPN1	3560	-2841
RPN2	3036	-688
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRAGA	2580	-1657
RTF1	1224	-4613
RTN4RL2	2945	-6031
RUVBL1	-2967	256
RWDD3	-86	-4374
SAE1	-2832	2410
SAFB	839	-3542
SAR1B	2704	489
SARS2	-3962	465
SATB1	-2483	-1979
SATB2	2725	-6456
SCMH1	-1695	1397
SEC11A	3549	-4081
SEC11C	-3068	-4262
SEC13	2286	-3749
SEC16A	1717	-1722
SEC22A	-1547	696
SEC22C	-1274	1879
SEC23A	3198	-5141
SEC23IP	-149	-38
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SEC61A1	2678	-592
SEC61A2	-4045	917
SEC61B	3029	33
SEC61G	1795	1052
SEH1L	-1833	-1615
SEL1L	2854	-2307
SENP1	-2676	-1254
SENP2	1427	-382
SENP5	-2145	261
SENP8	1020	-1816
SERP1	3877	520
SHC1	1469	-2954
SHISA5	398	1884
SHPRH	-2810	-353
SIAH1	-897	-6217
SIAH2	3939	2185
SIN3A	-3920	-4151
SKIV2L	-1019	-2116
SKP1	1561	-2290
SKP2	-2780	-1566
SLC17A5	1920	-3631
SLC30A5	-738	-2119
SLC30A6	10	-1069
SLC30A7	-1340	-2297
SLC35A1	3137	-4021
SLC35C1	881	-5366
SMAD1	3832	-3272
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMAD7	-4655	-4450
SMC3	-592	-1642
SMC5	-2312	-2372
SMC6	-1285	1981
SMURF2	-3700	-3048
SOCS2	-769	378
SOCS3	4414	2178
SOCS5	1047	-4583
SORL1	2753	-5169
SP100	1527	-769
SP3	2154	-3116
SPCS2	1082	2136
SPCS3	1589	437
SPON2	-4845	1081
SPSB1	772	-3865
SPSB3	-1841	-4699
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SRD5A3	1437	442
SRP14	2618	-848
SRP19	1544	-1180
SRP54	2770	-116
SRP68	644	1885
SRP72	-454	-2605
SRPRB	-3301	59
SSR1	2741	879
SSR2	913	-1242
SSR3	2394	-4032
ST3GAL1	-2411	1767
ST3GAL2	4018	-2686
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST3GAL5	-4489	1507
ST3GAL6	2764	-5427
ST6GAL1	-4644	1948
ST6GALNAC3	4287	145
ST6GALNAC4	-268	-5981
ST6GALNAC6	-4677	2144
ST8SIA1	-2619	-2246
ST8SIA4	3717	-3013
STAG1	-2003	-863
STAM	404	770
STAM2	2488	-2181
STAMBP	511	-93
STAMBPL1	-3745	-5600
STAT3	3649	-3606
STT3A	1453	-4222
STX17	-4112	-4247
STX1A	-1208	-2461
STX5	3070	-1823
SUDS3	1670	-1851
SUMF1	4123	-5376
SUMF2	-4745	-3692
SUMO1	2937	-3986
SUMO3	2962	-5577
SYVN1	322	-5153
TAF10	3073	1606
TARS2	-4566	-1091
TATDN2	-3285	2494
TBC1D20	-16	-5205
TBCA	2045	-1541
TBCB	908	-442
TBCC	-3497	-4485
TBCD	-3394	2325
TBCE	-981	-5873
TCF7L2	-1653	-3431
TCP1	1261	2168
TDG	2829	621
TFPT	2063	-333
TGFA	4154	-3020
TGFB1	1971	-6
TGFBR1	507	-6163
TGFBR2	1344	-5224
TGOLN2	3932	-2836
THRA	-1980	-2798
TLN1	3884	191
TMED10	104	604
TMED2	2437	-3656
TMED3	893	-2936
TMED7	3495	1939
TMED9	3079	-1992
TMEM115	2179	-703
TMEM129	1361	1624
TNFAIP3	-4190	-785
TNIP1	3834	-2256
TNIP2	2191	-5726
TNKS	-3013	-1583
TNKS2	-164	-449
TOMM20	-819	2451
TOP1	3349	-2610
TOP2A	944	192
TOP2B	-813	-3244
TOPORS	925	462
TP53	-4078	-739
TP53BP1	-4059	-2967
TPGS1	1578	1697
TPGS2	-959	-4475
TPP1	4034	237
TPR	-2272	-973
TPST1	4354	-2233
TPST2	2313	-2387
TRAF2	-4465	-1442
TRAF3	-1622	2379
TRAF6	-81	-6118
TRAM1	-1400	-1688
TRAPPC1	3480	-3029
TRAPPC10	-3321	2388
TRAPPC2L	-690	1441
TRAPPC3	3050	-2853
TRAPPC4	-2164	-3231
TRAPPC5	2001	-5629
TRAPPC6A	-4070	1765
TRAPPC6B	1486	-662
TRAPPC9	2076	-4354
TRIM13	-684	497
TRIM25	3724	-3718
TRIM27	3711	-1744
TRIM28	-1482	1191
TRMT112	184	-4666
TRRAP	-2130	1860
TSFM	430	100
TSPAN14	2956	1366
TSPAN33	2556	-5908
TSPAN5	337	-6310
TSTA3	2570	1496
TTF1	-87	-4199
TTL	-1190	-4334
TTLL1	-2535	-5225
TTLL11	-1575	-5747
TTLL12	2083	1569
TTLL3	-711	-2560
TTLL4	3507	-4814
TTLL5	-1229	-3569
TTLL7	2590	-1018
TUBA1A	3204	-4767
TUBA1B	2167	-1058
TUBA1C	3101	-150
TUBA4A	2717	-4571
TUBA4B	615	-5863
TUBB2A	4013	-4771
TUBB4B	3154	1856
TUFM	1621	-69
TXN	3798	284
UAP1	-4800	-3110
UBA2	-2047	1399
UBA3	3408	-2122
UBA52	344	752
UBA6	1181	1251
UBB	2801	-1321
UBC	1599	-2568
UBE2B	3032	-2486
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2E3	1918	-5759
UBE2F	3224	-3774
UBE2G1	1879	-1626
UBE2G2	-2597	-3560
UBE2H	3435	-1867
UBE2I	-239	233
UBE2J2	3785	-368
UBE2K	2853	1379
UBE2L3	3307	-3496
UBE2L6	-4358	-4206
UBE2M	3295	-3585
UBE2N	616	1127
UBE2Q2	-4499	-4146
UBE2R2	3891	-3277
UBE2S	1785	2449
UBE2T	-2970	-2989
UBE2V2	965	-3487
UBE2W	3511	-618
UBE2Z	-4161	-4538
UBXN1	597	-2222
UBXN7	496	-1320
UCHL3	630	-752
UCHL5	-2631	-6243
UGGT1	1936	-3498
UHRF2	-3471	-1716
UIMC1	4301	-3114
USO1	1479	1196
USP10	3332	-5328
USP12	1891	-4528
USP13	-2115	-667
USP14	-1608	-5011
USP15	2399	686
USP16	-2668	1533
USP18	-4831	-2616
USP19	-150	492
USP20	-4218	2238
USP21	-2098	-3841
USP22	2814	-3087
USP24	-4315	1979
USP25	49	1721
USP28	-4855	-3970
USP3	3931	-267
USP30	270	-2625
USP33	-260	-5582
USP34	-296	-4481
USP4	3431	-5610
USP42	-4398	-3364
USP44	-2437	-4859
USP47	-1178	-3304
USP48	1603	-4606
USP49	853	1872
USP5	-1900	-173
USP7	2617	-2216
USP8	2599	-424
VAMP2	-4530	-2770
VARS2	-1825	-5297
VCP	2927	-2411
VCPIP1	-92	-476
VCPKMT	96	-631
VDAC1	1532	-3624
VDAC3	150	1058
VDR	3712	-3651
VHL	1285	1389
WAC	2039	53
WARS2	-1437	-764
WDR20	-345	-4288
WDR48	-4493	-5481
WDR5	39	-5613
WDR61	28	-4752
WDTC1	2893	-205
WFS1	-3419	409
WIPI1	3143	-1090
WRAP53	-3241	-3158
WRN	-4674	-2102
WSB1	3452	-637
WSB2	3335	-6513
XPC	-4425	-402
XRCC4	2832	-3706
XRN2	4368	-5589
YARS2	-1216	-3405
YIF1A	-69	-5708
YKT6	2009	-3331
YOD1	3305	-556
YY1	169	-5165
ZBTB16	391	2289
ZBTB17	546	-891
ZDHHC2	2029	-3322
ZNF131	-4182	-423

---

---

rRNA processing

rRNA processing

metric	value
setSize	159
pMANOVA	1.71e-11
p.adjustMANOVA	1.75e-09
s.dist	0.336
s.RNA	-0.289
s.meth	0.171
p.RNA	3.67e-10
p.meth	0.000207

Top 20 genes

Gene	RNA	meth
NOP14	-4072	2384
RRP9	-3599	2034
RPL3	-2866	2313
RPL23A	-3305	1843
MTERF4	-3859	1559
NOL9	-3678	1426
EXOSC2	-4042	1269
RPL13A	-2702	1802
RPS11	-2281	2115
EXOSC8	-4307	1020
SNU13	-2197	1961
RPL32	-2060	1928
WDR75	-3459	1028
RPP38	-2173	1598
NOC4L	-1679	1990
RPS2	-1347	2392
RPL35	-2748	952
RPL4	-1061	2321
RPS10	-1744	1246
NOL6	-4033	526

Click HERE to show all gene set members

All member genes

	RNA	meth
BMS1	-4477	-2552
BYSL	-1313	-88
C1D	1236	510
CSNK1D	771	-1777
CSNK1E	-3694	-4750
DCAF13	-1724	-2001
DDX21	1019	760
DDX47	-4203	-3056
DDX49	1837	-4408
DDX52	161	-1954
DHX37	-2778	-312
DIS3	-1302	-762
EBNA1BP2	-1242	1600
ELAC2	-4602	-916
ERI1	2175	130
EXOSC1	-309	-290
EXOSC10	-4357	-1580
EXOSC2	-4042	1269
EXOSC3	153	-2555
EXOSC4	3412	-4410
EXOSC5	-1316	1591
EXOSC6	-3569	545
EXOSC7	-3984	-4665
EXOSC8	-4307	1020
FAU	-129	-3862
FBL	-3630	-2611
FCF1	1658	-2675
FTSJ3	-1175	-670
GAR1	-2237	-4416
GNL3	-2812	-1419
HEATR1	-3704	-1985
IMP3	-3221	99
IMP4	-3938	-2925
ISG20L2	1327	1893
KRR1	-2919	-6562
LTV1	-1261	-3205
MPHOSPH10	-2599	-57
MPHOSPH6	711	-5463
MRM1	-3331	-5990
MTERF4	-3859	1559
NCL	-3268	-2515
NHP2	-1035	-260
NIP7	-1832	-1760
NOB1	-3760	-1000
NOC4L	-1679	1990
NOL11	-3686	-2629
NOL12	1849	505
NOL6	-4033	526
NOL9	-3678	1426
NOP10	3831	-3526
NOP14	-4072	2384
NOP2	-3314	-2438
NOP56	-4412	-523
NOP58	-3586	-2406
NSUN4	-1455	-3469
PDCD11	-4437	-2174
PELP1	-4029	-1579
PES1	-604	-3908
PNO1	-2216	-5495
PWP2	-312	681
RBM28	-4525	-685
RCL1	-272	-1421
RIOK1	-1124	-2098
RIOK2	305	-954
RIOK3	4000	-2443
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPP14	1011	-354
RPP21	-1592	-5256
RPP25	-2803	-5917
RPP30	-2733	-5522
RPP38	-2173	1598
RPP40	-1422	-1426
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRP1	-936	77
RRP7A	-853	-2961
RRP9	-3599	2034
SENP3	975	-1248
SNU13	-2197	1961
TBL3	-1028	994
TEX10	-3484	-1947
TFB1M	-4339	-3739
THUMPD1	-3487	-4292
TRMT112	184	-4666
TSR1	-3373	-3041
TSR3	1352	1167
UBA52	344	752
UTP15	-3865	-2796
UTP18	1954	-3819
UTP20	-3801	-1372
UTP3	-883	-3665
UTP6	-1353	-1904
WDR12	2015	706
WDR18	-707	-2042
WDR3	-2064	-5710
WDR36	-1144	-2277
WDR43	-2465	-4225
WDR75	-3459	1028
XRN2	4368	-5589

---

---

Signaling by Interleukins

Signaling by Interleukins

metric	value
setSize	262
pMANOVA	1.72e-11
p.adjustMANOVA	1.75e-09
s.dist	0.252
s.RNA	0.252
s.meth	0.0162
p.RNA	3.27e-12
p.meth	0.655

Top 20 genes

Gene	RNA	meth
SOCS3	4414	2178
LCP1	3800	2024
IL19	2870	2517
PPP2CB	3404	1797
MAPK1	3257	1865
NOD2	3786	1528
TAB2	2991	1892
TNFRSF1B	2338	2416
BATF	2672	2070
ITGB2	4091	1322
PSMA7	3060	1752
FOS	2486	2149
PIK3CD	2436	2189
BCL2L1	4028	1306
PSMD1	3121	1660
CNN2	2792	1735
CBL	3300	1456
CHUK	3527	1343
PSME3	3757	1116
SMARCA4	1769	2317

Click HERE to show all gene set members

All member genes

	RNA	meth
AIP	-1079	1761
AKT1	1248	-1942
ALOX5	4195	-6082
APP	4212	-5300
ARF1	4190	-6686
ATF1	2271	-2565
BATF	2672	2070
BCL2	-1339	2361
BCL2L1	4028	1306
BCL6	4305	-299
BIRC5	1432	-84
BRWD1	-3181	-3884
BTRC	-1491	-2427
CANX	2138	-4839
CAPZA1	3657	572
CASP1	1434	-1448
CASP3	-160	-2764
CBL	3300	1456
CCND1	-2169	-6213
CCR1	4062	-6480
CD4	-1631	-6372
CDC42	3265	-2719
CDKN1A	1606	-3540
CEBPD	4041	-5142
CFL1	3703	912
CHUK	3527	1343
CISH	1861	1748
CNN2	2792	1735
CREB1	-423	-672
CRK	4109	-4581
CRKL	1383	-906
CSF1	-605	-5924
CTF1	1575	-5738
CUL1	-4385	-5146
CXCL2	2131	-6755
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
FBXW11	2542	-6747
FOS	2486	2149
FOXO1	-3171	-5036
FOXO3	3983	711
FYN	-4569	1957
GAB2	3616	-6153
GATA3	-4787	1861
GRB2	4321	-2295
GSTO1	4196	-170
HIF1A	3192	-3349
HMGB1	-66	-1263
HNRNPA2B1	1139	-2665
HNRNPF	1377	-58
HSP90AA1	415	-781
HSP90B1	655	-1371
HSPA9	-3551	-200
ICAM1	2834	-5333
IKBKB	-1620	-3894
IL10RA	-3987	1263
IL10RB	4247	-6138
IL12A	-2392	-5748
IL12RB1	-4763	-1444
IL12RB2	-4720	-5603
IL15	-1627	-5098
IL15RA	829	-3679
IL16	-3204	656
IL17C	-2092	-1115
IL17RA	4276	-3604
IL17RC	56	-1157
IL18BP	-3970	-5936
IL18R1	1550	475
IL19	2870	2517
IL1RAP	3160	-456
IL21R	-4811	401
IL23A	-3468	-6478
IL27RA	1175	-1230
IL2RA	-2353	-6462
IL2RB	-4875	2472
IL32	-3423	2512
IL4R	3205	-4452
IL6R	3697	-6410
IL6ST	1389	1094
INPP5D	-1183	-3735
INPPL1	4209	-2224
IRAK2	-3415	-1457
IRAK3	4111	-6295
IRF4	-3077	1782
IRS1	563	-4060
IRS2	3752	-5410
ITGB2	4091	1322
JAK1	-4154	-1022
JAK2	834	-1751
JUN	1372	69
JUNB	2887	-3031
LCK	-4404	2489
LCP1	3800	2024
LGALS9	924	-6589
LMNB1	4362	-942
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K3	3766	64
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MIF	-1139	-2943
MTAP	-1778	-5878
MUC1	2718	-5557
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
OSM	3463	-3652
P4HB	3824	-1549
PAK2	3694	-3961
PDCD4	-4581	1941
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIM1	3428	-5227
PITPNA	2872	-2752
POU2F1	497	733
PPIA	-2188	490
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PRKACA	4377	-6032
PRTN3	2850	-6448
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTK2B	3561	40
PTPN11	2065	-2302
PTPN12	3633	-1077
PTPN13	-3647	-6489
PTPN18	2351	693
PTPN2	3324	-3701
PTPN23	-369	-3227
PTPN4	-4781	-3156
PTPN6	2483	-4586
PTPN7	-4117	-1888
PTPN9	2738	-1265
RALA	865	-262
RAP1B	1106	-1031
RAPGEF1	-3584	1868
RBX1	1413	-3241
RELA	-541	2085
RORA	-4632	2287
RPLP0	-325	-185
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
S1PR1	-3197	2436
SHC1	1469	-2954
SIGIRR	-3945	290
SKP1	1561	-2290
SMAD3	-4431	-4628
SMARCA4	1769	2317
SNRPA1	-3646	-3336
SOCS1	1346	-2999
SOCS2	-769	378
SOCS3	4414	2178
SOCS5	1047	-4583
SOD1	-1490	-1019
SOD2	1617	573
SOS1	-1758	-6775
SOS2	3767	-4105
SQSTM1	1450	-952
STAT1	-4575	2195
STAT2	-4052	-3295
STAT3	3649	-3606
STAT4	-4853	-425
STAT5A	2944	-6427
STAT5B	2958	-3446
STAT6	2355	-3911
STX1A	-1208	-2461
STX3	3897	-1755
STX4	200	-6001
STXBP2	4178	-6352
SYK	4194	-5054
TAB2	2991	1892
TALDO1	4405	-5245
TBK1	1029	-4616
TCP1	1261	2168
TEC	3241	-5839
TGFB1	1971	-6
TNF	-2330	-3779
TNFRSF1A	4337	-4958
TNFRSF1B	2338	2416
TNIP2	2191	-5726
TOLLIP	3944	-5037
TP53	-4078	-739
TRAF6	-81	-6118
TXLNA	-551	-78
TYK2	3075	-3105
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2N	616	1127
UBE2V1	2217	-1021
VAMP2	-4530	-2770
VAV1	3569	-3184
VEGFA	3184	-2723
VIM	4364	-2247
VRK3	402	-1398
YES1	-4790	-4415
YWHAZ	2220	541
ZEB1	-2241	-1406

---

---

Metabolism

Metabolism

metric	value
setSize	1215
pMANOVA	2.4e-11
p.adjustMANOVA	2.24e-09
s.dist	0.125
s.RNA	0.124
s.meth	-0.0153
p.RNA	2.79e-12
p.meth	0.39

Top 20 genes

Gene	RNA	meth
GNA15	4401	-6690
GGT1	4400	-6607
ACSS2	4388	-6534
DSE	4412	-6498
TSPO	4360	-6553
GLUL	4173	-6758
PTGR1	4198	-6711
ARF1	4190	-6686
GNAQ	4150	-6733
ENO1	4071	-6654
TBXAS1	3948	-6709
PRKACA	4377	-6032
MGST2	4024	-6536
PLD1	4274	-6058
ALOX5	4195	-6082
HYAL2	4232	-5951
SLC16A3	4075	-6120
COMT	3713	-6677
NT5C2	3903	-6291
NUDT16	3957	-6171

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
AACS	107	843
AANAT	2	-4522
ABCA1	2422	-6487
ABCC1	187	-871
ABCC5	814	-2379
ABCD4	-2847	-4648
ABHD10	-2077	-4844
ABHD14B	-3508	-1729
ABHD3	2978	-4046
ABHD4	2681	-5841
ABHD5	3483	-5560
ACAA1	3791	1410
ACACA	2069	-164
ACACB	-3479	-4884
ACAD10	1812	-83
ACAD11	-3735	-2327
ACADM	-393	-2163
ACADS	1571	-6188
ACADSB	-3839	-2708
ACAT1	2162	-2579
ACAT2	-1087	-2151
ACBD4	-1304	-2973
ACBD5	-382	-2520
ACBD6	-4120	-1414
ACBD7	1110	-5886
ACER2	651	-2800
ACER3	4238	-1641
ACLY	1979	-5417
ACOT13	2120	-3113
ACOT7	-946	1021
ACOT8	3634	-2563
ACOX1	4116	-5075
ACOX3	2419	-4725
ACOXL	1787	2527
ACP5	-561	-5814
ACP6	-1140	-5222
ACSF2	-4350	-5644
ACSF3	-119	-5695
ACSL1	4329	-1604
ACSL3	3508	-4285
ACSL5	-3940	-215
ACSL6	-1755	2501
ACSM1	-3426	-6655
ACSM3	-2417	-6252
ACSS1	-4668	-3949
ACSS2	4388	-6534
ACY1	-1397	-1933
ADA	-4849	1567
ADAL	-4320	-2064
ADCY4	1985	-6389
ADCY7	-982	-5596
ADCY9	46	-2618
ADH5	-2722	-946
ADHFE1	-1541	17
ADIPOR1	4375	-2029
ADIPOR2	1862	-3302
ADK	-661	-4448
ADO	-544	1444
ADPGK	2199	-1337
ADSL	1945	-43
AFMID	2295	-3146
AGK	-4734	-3004
AGL	-952	-3188
AGMAT	-1615	859
AGPAT1	3720	559
AGPAT2	4297	2250
AGPAT3	1685	-2039
AGPAT4	-2900	-4185
AGPAT5	-3437	221
AGPS	2085	-3742
AGRN	-4590	-2304
AHCY	140	-5043
AHCYL1	2655	-3553
AHR	3094	2099
AHRR	-1817	-702
AIMP2	-288	-4973
AIP	-1079	1761
AK2	783	-1881
AK9	83	-5789
AKR1A1	455	-4351
AKR1B1	-4560	1845
AKR7A2	837	-6736
AKT1	1248	-1942
ALAD	3905	-1369
ALDH18A1	-4158	-2831
ALDH1B1	-4125	-1808
ALDH3A2	286	-2186
ALDH4A1	4300	-4122
ALDH6A1	1409	-112
ALDH9A1	958	-1095
ALDOA	4289	-1349
ALDOC	-994	-6226
ALOX5	4195	-6082
ALOX5AP	3592	-6710
AMACR	-2263	-663
AMD1	1245	-2184
AMDHD1	-663	-729
AMPD2	2100	-6207
AMPD3	4050	-5620
APRT	-829	-204
ARF1	4190	-6686
ARF3	3423	-1912
ARG2	2233	-3974
ARNT	3603	1140
ARNTL	-2187	-4129
ARSA	1185	-3099
ARSB	3173	-5722
ARSG	-1451	152
ARSK	-4241	-54
ARV1	-812	-2677
ASAH1	3775	335
ASL	2333	-4506
ASNS	-2777	12
ASRGL1	1915	-6497
ATIC	-4166	2083
AUH	-372	700
AZIN1	3092	1461
AZIN2	-4155	-6241
B3GALT4	2107	-394
B3GALT6	-1361	2030
B3GAT2	-562	-5068
B3GAT3	-902	646
B3GNT2	2380	-1684
B3GNT7	-4852	-6593
B4GALT1	1562	-160
B4GALT2	-1893	1307
B4GALT3	-3906	-4680
B4GALT4	185	-1422
B4GALT5	4092	52
B4GALT6	-3085	-6484
B4GALT7	-2379	482
B4GAT1	-1747	451
BCAT1	3566	-6102
BCAT2	-908	-482
BCKDHA	2461	-3682
BCKDHB	-4222	-3761
BCKDK	4165	-3369
BDH1	-3796	-5778
BDH2	-4267	-6434
BLVRA	2267	1170
BLVRB	4374	-5026
BPHL	-3021	-3139
BPNT1	-351	-1649
BRIP1	-4545	-2323
BSG	4260	-1562
BTD	-4762	146
CA13	389	-3867
CA6	-726	1612
CACNA1C	-3959	-4608
CACNA2D2	-4606	-64
CACNB3	110	-6297
CAD	-3210	1818
CALM1	-614	-5019
CARNMT1	-3956	2061
CARNS1	-3936	-5922
CAV1	584	-2432
CBR3	-2751	-6380
CBR4	-381	-2264
CCNC	596	-1138
CD320	-3345	103
CD38	-4704	-5254
CD44	3745	266
CDIPT	2558	-2467
CDK19	3360	-2575
CDK8	-597	-5509
CDS2	2757	979
CEPT1	360	289
CERK	-1619	1601
CERS5	-662	-6266
CERS6	2279	-3796
CES2	2568	-6637
CHAC2	-1821	-1353
CHD9	-1356	-5791
CHKA	2438	-4562
CHKB	-966	816
CHP1	4283	-4961
CHPF	-3868	1258
CHPF2	3492	-3165
CHPT1	4069	-5900
CHST11	1805	-4503
CHST12	-4881	761
CHST14	372	-6351
CHST2	-4278	1725
CHSY1	3686	-4487
CIAO1	-3660	-1918
CIAPIN1	-2662	-2503
CKB	-4692	-4979
CLOCK	-2413	-1159
CMBL	2613	-6545
CMPK1	-466	-3522
CNDP2	-1443	-1531
COASY	3402	-790
COMT	3713	-6677
COQ10A	-4226	-2921
COQ10B	1423	-2505
COQ2	3023	-5067
COQ3	-3372	-2779
COQ5	2245	-3083
COQ6	-4540	-1910
COQ7	1759	1971
COQ9	-2760	695
COX10	-1827	524
COX11	-4162	-789
COX14	-463	-3835
COX15	3529	522
COX16	66	-1160
COX19	-2202	-4047
COX20	-1528	-4841
COX4I1	1505	-5506
COX5A	2520	-2944
COX5B	2572	382
COX6A1	1958	-961
COX6B1	2260	-2634
COX6C	228	-1411
COX7A2L	3430	-2476
COX7C	178	-4071
COX8A	2789	-1258
CPNE1	-1013	1274
CPNE3	2359	-2088
CPOX	-205	1290
CPS1	-940	314
CPT1A	1949	-6398
CPT2	2687	-6494
CPTP	1273	-2096
CRAT	4114	-4890
CREBBP	1169	-5804
CRLS1	4214	-4654
CRYL1	1896	-4672
CRYM	3516	-1596
CS	1260	294
CSAD	3091	1962
CSGALNACT1	1456	2502
CSGALNACT2	3682	194
CSNK1G2	289	-1639
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CTH	-2689	-475
CTPS1	-3605	1679
CTSA	4423	-4847
CYB5A	-1689	-4677
CYB5B	-4329	-2367
CYB5R3	4077	-1540
CYC1	1022	464
CYCS	-386	-3927
CYP2R1	-3592	-1915
CYP2U1	-4695	-4531
CYP46A1	-108	1529
CYP4F22	-4843	-2371
CYP4V2	-3320	-4041
CYP51A1	2920	-5191
D2HGDH	-1753	-3476
DBI	2593	441
DBT	-1704	-4561
DCK	-2939	1411
DCTD	-3698	-1612
DCTPP1	-523	-3112
DCXR	-101	-2013
DDAH2	3628	-5633
DDHD1	-4445	1414
DDHD2	-4506	-2861
DECR1	2010	-528
DECR2	307	830
DEGS1	2545	-193
DERA	3816	-756
DGAT1	2058	-6115
DGAT2	4293	-1911
DGUOK	935	1248
DHCR24	911	-5657
DHCR7	2895	-3544
DHFR	2006	216
DHODH	-1713	-51
DHRS7B	3291	-3549
DHTKD1	2211	208
DLAT	-1052	-1484
DLD	3104	1320
DLST	-3123	-1986
DNM2	2474	738
DPEP2	-826	-6530
DPYD	4227	-135
DSE	4412	-6498
DSEL	-485	-4
DTYMK	-3338	-174
DUT	-1868	1287
ECHS1	-683	-1673
ECI1	165	-4832
ECI2	-4595	-2127
ECSIT	1866	-4938
EEF1E1	-639	-1336
EEFSEC	-3693	-1968
EHHADH	2481	-6438
ELOVL1	3061	-1168
ELOVL4	-1775	-2987
ELOVL5	2426	-3408
ELOVL6	-4462	-1124
ENO1	4071	-6654
ENO2	-2739	639
ENO3	-2183	-4590
ENOPH1	-3811	1736
ENPP2	627	-2276
ENTPD1	3776	2446
ENTPD4	-1913	-1106
ENTPD5	-1942	-4305
ENTPD6	-1424	-5875
ENTPD7	3663	626
EP300	2504	-4509
EPHX1	-3480	-6422
EPHX2	-3486	-5989
ERCC2	1202	-594
ESD	2700	-4602
ESRRA	2370	-2927
ESYT1	-4767	959
ESYT2	-4518	-1193
ETFA	3913	709
ETFB	3405	-3921
ETFDH	3610	868
ETHE1	4008	-651
ETNK1	-430	1286
EXT1	2906	-5359
EXT2	-434	-1799
FABP5	2453	-3534
FADS1	3438	-4312
FADS2	512	-5605
FAH	4382	-5132
FAHD1	64	-6373
FAM120B	-9	-2607
FAR1	3989	-224
FASN	-220	1100
FAU	-129	-3862
FBP1	3153	-4762
FDFT1	3218	-4585
FDPS	2086	124
FDX1	607	-3747
FDXR	1779	-3448
FECH	2943	-3650
FH	949	-575
FIG4	4184	-5382
FITM2	-1795	-2082
FLAD1	-2872	1221
FLVCR1	-2782	-1280
FPGS	-3923	1728
FUT10	-1705	-3470
FUT11	-4814	-37
FUT4	3066	-6552
FXN	-4306	-619
G6PC3	1369	-6318
GAA	3578	-3801
GALC	3838	264
GALE	1941	-105
GALK1	4095	-2705
GALT	-3046	-325
GAPDH	4358	1359
GBA	4159	-5623
GBA2	973	-4419
GCDH	-727	-4658
GCH1	-2469	-2007
GCHFR	2113	316
GCLC	-4576	-1829
GCLM	2152	-248
GCSH	-2793	-4566
GDE1	3933	-5040
GDPD1	-1379	-1268
GDPD5	-3901	-2713
GGCT	-2020	-2907
GGPS1	-314	-2782
GGT1	4400	-6607
GGT7	-2640	-3
GLB1	3936	1368
GLCE	4038	258
GLIPR1	3427	-2351
GLO1	-1120	-3115
GLRX	3544	-3309
GLRX5	3973	1149
GLS	-4521	-4781
GLTP	3827	-5867
GLUD1	2148	-2194
GLUL	4173	-6758
GLYCTK	-1173	-1256
GM2A	4138	-825
GMPR	3893	-5096
GMPR2	3401	-2545
GMPS	-1669	-1416
GNA15	4401	-6690
GNAI2	3614	-1747
GNAQ	4150	-6733
GNAS	3567	951
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GNPDA1	3888	-210
GNPDA2	-2814	-2636
GNS	4312	-571
GOT1	-4556	190
GOT2	-3474	-1064
GPAM	-3559	-4630
GPC2	-1070	-6477
GPCPD1	3801	-203
GPD1	-2210	-6250
GPD1L	-3917	-2487
GPD2	3273	-6521
GPHN	-2303	-4806
GPI	2523	-2211
GPS2	-290	-857
GPT2	1513	-6135
GPX1	4356	-5467
GPX4	1974	-455
GRHPR	326	1463
GSR	4279	-4724
GSS	221	-1739
GSTA4	-2908	-4624
GSTK1	-491	1037
GSTM3	-512	-6312
GSTM4	386	-4359
GSTO1	4196	-170
GSTO2	-957	1658
GSTP1	62	-5415
GSTZ1	2101	701
GUK1	2130	91
GUSB	3221	-4967
GYG1	4223	-5541
GYS1	3086	-1092
HACD1	1663	-4245
HACD2	-520	1513
HACD3	-4003	2329
HACD4	2852	500
HACL1	-4577	-3683
HADH	-4304	-4809
HADHA	3987	1866
HADHB	4385	-968
HAGH	1947	-4846
HDAC3	1740	-3771
HEXA	397	-4273
HEXB	3996	-5777
HIBADH	-2880	-4592
HIBCH	-858	-1008
HILPDA	-474	670
HK1	4140	479
HK2	4315	-5015
HLCS	-4574	1551
HMBS	2331	-2717
HMGCL	2061	1969
HMGCR	3683	-3388
HMGCS1	-599	-2608
HMMR	1420	-3568
HMOX2	-4584	2130
HPD	3317	-3768
HPGD	3383	-6446
HS3ST3B1	-2902	-4926
HS6ST1	1684	-5621
HSCB	970	-3590
HSD17B1	1246	1940
HSD17B11	3617	-3328
HSD17B12	3123	-895
HSD17B4	4070	-5528
HSD17B8	-3846	2077
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HYAL1	1530	-6777
HYAL2	4232	-5951
HYAL3	1992	847
IDH1	4421	-2333
IDH2	-885	-798
IDH3A	-3279	-1594
IDH3B	-467	-2553
IDI1	2830	1929
IDUA	-1786	932
IL4I1	-3722	-6308
IMPA1	-218	-1820
IMPA2	4418	-505
IMPAD1	1233	-5680
IMPDH1	4348	-750
IMPDH2	-3359	446
INPP1	-441	-6045
INPP4A	-3443	2209
INPP5A	2946	-5525
INPP5B	-2191	-5762
INPP5D	-1183	-3735
INPP5E	-2503	2080
INPP5F	-1475	507
INPP5K	-603	1585
INPPL1	4209	-2224
INSIG1	-3875	947
INSIG2	2691	-4256
IP6K1	1422	930
IP6K2	-3705	-878
IPMK	3515	1897
IPPK	1074	-6048
IQGAP1	3672	1271
ISCA1	2602	-2023
ISCU	-565	70
ITPA	-2869	-3773
ITPK1	2823	-2385
ITPKB	-4295	1418
ITPKC	4093	-5392
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
IVD	-4830	-3067
KCNJ11	-1204	-2105
KHK	-2302	-1547
KMO	-2093	-5979
KPNB1	799	-2176
L2HGDH	-3609	-3657
LBR	3693	-3506
LCLAT1	-65	-2733
LDHA	3992	-4161
LDHB	-3411	-3504
LDLR	2573	-494
LGMN	-1423	313
LHPP	-1	-2536
LIAS	-1865	-4260
LIPE	-3073	-5437
LIPT1	-4293	1548
LIPT2	-2339	-4195
LMBRD1	2726	-156
LPCAT1	-2464	1540
LPCAT3	3956	-3100
LPCAT4	-2741	1628
LPGAT1	3889	-5760
LPIN1	-4324	-2651
LPIN2	-2222	2060
LRP10	3078	2161
LRP12	2614	-6362
LRP8	1683	-214
LRPPRC	-3636	-5728
LSS	-3854	-4805
LTA4H	4306	-972
LTC4S	-116	-6617
LYPLA1	3582	184
LYRM4	-1879	623
MAN2B1	2866	-6345
MAN2B2	1542	-4433
MAN2C1	-1161	928
MANBA	3165	1807
MAPKAPK2	1470	2012
MAT2A	-1248	1455
MAT2B	-3867	-2153
MBOAT1	2117	-4287
MBOAT7	3930	-3703
MBTPS1	951	-398
MCAT	2137	-3215
MCCC1	-3158	-4716
MCCC2	-4621	1857
MCEE	-1431	320
MDH1	638	-461
MDH2	1515	2515
ME2	2936	504
ME3	-3640	-4969
MECR	-2375	350
MED1	-1217	-2271
MED10	-2937	-2572
MED11	-225	609
MED13	824	590
MED13L	2446	-533
MED15	-3549	2114
MED16	2032	1719
MED17	967	-1418
MED18	1632	-186
MED19	1088	-4664
MED20	2864	-542
MED21	-1738	-582
MED22	1282	-2059
MED23	-2103	633
MED24	-2416	-2701
MED25	2547	-1286
MED26	1615	18
MED27	-3240	-960
MED28	-424	699
MED29	-2664	-5128
MED30	-1688	491
MED31	456	445
MED4	1079	-4472
MED6	-284	560
MED7	55	778
MED8	3319	1289
MED9	-3072	-3399
MFSD2A	-677	-5062
MGST2	4024	-6536
MGST3	2720	-524
MINPP1	-339	-1874
MLX	3802	-3367
MLYCD	-3448	97
MMAA	-4458	-3965
MMAB	-3148	-850
MMACHC	-2095	-266
MMADHC	2634	-3748
MMS19	-2574	1975
MOCOS	1132	-6155
MOCS2	-3226	-3611
MOCS3	-2138	-4731
MORC2	-3116	2508
MPC2	1688	-216
MPST	3493	-6010
MSMO1	836	1922
MTAP	-1778	-5878
MTF1	4099	-2992
MTHFD1	-4334	1071
MTHFD1L	127	-4124
MTHFD2	3652	-541
MTHFR	1917	-5449
MTHFS	3882	195
MTMR10	3605	-3555
MTMR12	-489	-579
MTMR14	3552	-4278
MTMR2	-674	519
MTMR3	4203	-2340
MTMR4	962	-1420
MTMR6	3451	1477
MTMR9	458	-2578
MTR	-4637	448
MTRR	634	-694
MVD	-1820	1954
MVK	-2844	-2474
N6AMT1	-3939	1363
NADK	3407	-4598
NADK2	-2334	1853
NADSYN1	1151	-2603
NAGLU	-1458	-5716
NAGS	999	-4627
NAMPT	3364	1077
NAPRT	3249	-6164
NAT1	2841	-6568
NCOA2	352	1407
NCOA3	1207	-2266
NCOA6	2298	-1860
NCOR1	2375	-3738
NCOR2	3521	-4281
NDC1	-4771	-5228
NDST2	3533	-5041
NDUFA10	-2238	-3014
NDUFA11	452	-5059
NDUFA12	-531	-3525
NDUFA13	1528	-4567
NDUFA2	1881	-867
NDUFA3	168	-23
NDUFA4	2716	288
NDUFA5	-1427	1424
NDUFA6	2444	-3626
NDUFA7	2226	-770
NDUFA8	1811	-3780
NDUFA9	-3066	-3913
NDUFAB1	2302	-395
NDUFAF1	3732	-5134
NDUFAF2	684	-2692
NDUFAF3	3007	-5045
NDUFAF4	-3499	493
NDUFAF5	-3410	-6281
NDUFAF6	-680	-5694
NDUFB1	3340	-4478
NDUFB10	2319	-599
NDUFB2	-1337	1946
NDUFB3	3872	-1362
NDUFB4	1674	1157
NDUFB5	1376	-1595
NDUFB7	746	358
NDUFB9	3760	-6083
NDUFC1	2088	563
NDUFC2	2499	-4977
NDUFS1	2581	1355
NDUFS2	2478	-6412
NDUFS3	301	-2069
NDUFS4	1410	438
NDUFS5	2528	1325
NDUFS6	1510	-853
NDUFS7	670	-1679
NDUFS8	23	-733
NDUFV1	-4401	-5982
NDUFV2	1557	-2346
NDUFV3	1966	-1432
NEU1	4191	-3878
NEU3	-1129	-1409
NFYA	1190	1464
NFYB	-3535	-531
NFYC	3381	-3078
NHLRC1	-1718	-5836
NME1	552	-318
NME2	582	-4319
NME3	-213	-5409
NME4	1984	-6601
NMNAT1	4299	-1129
NMNAT3	-790	-5984
NMRAL1	-2234	182
NMRK1	-1055	2135
NNT	1613	-5319
NOS3	-515	-1770
NOSIP	-1986	-3257
NQO1	-944	-5372
NQO2	3970	-3750
NR1D1	-2922	1187
NR1H2	3254	-1471
NR1H3	-1011	-2305
NRF1	-2774	-4642
NT5C	-3250	-3125
NT5C2	3903	-6291
NT5C3A	1625	-5395
NT5M	2421	-3759
NUBP1	1661	-1534
NUBP2	-3225	1053
NUDT1	-1004	1174
NUDT12	-532	-5327
NUDT13	-1673	-6538
NUDT15	-884	-1515
NUDT16	3957	-6171
NUDT18	1221	-1364
NUDT19	2689	1908
NUDT3	2230	-3971
NUDT4	3248	-6105
NUDT5	-1031	1842
NUDT7	338	593
NUDT9	2011	-898
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
OAT	4096	-4268
OAZ1	4285	865
OAZ2	4064	-1403
OAZ3	-1310	-4957
ODC1	1109	-3950
OGDH	1455	1211
ORMDL1	-1848	-584
ORMDL3	-3560	-2716
OSBP	-795	-3696
OSBPL2	1964	-2911
OSBPL3	-4646	375
OSBPL5	-4813	-6730
OSBPL7	-4508	-4735
OSBPL8	2987	-2735
OSBPL9	2669	-2108
OXCT1	-4420	1553
PAICS	-1570	-839
PANK1	59	-5190
PANK2	3320	-5941
PANK3	977	-3008
PANK4	-2887	2199
PAOX	-3993	2169
PAPSS1	4158	1297
PARP10	-2831	2302
PARP14	-4650	864
PARP16	-4459	678
PARP4	1531	-715
PARP6	-1500	-3268
PARP8	-2888	-759
PARP9	-1402	1117
PC	4322	-5175
PCBD1	3006	-436
PCCB	-2665	-6219
PCK2	-188	-4164
PCTP	4342	-3451
PCYT1A	2903	822
PCYT2	-4288	-2669
PDHB	1526	-3400
PDHX	1556	1616
PDK1	1517	-2149
PDK2	-2699	-941
PDP1	-1281	-1207
PDP2	-4219	-2658
PDPR	-2400	-784
PDSS1	3389	-6036
PDSS2	2758	-1857
PDXK	3943	-5028
PECR	4063	2064
PEMT	1021	-4605
PEX11A	-3101	-2595
PFAS	-3928	-1753
PFKFB2	2420	-3582
PFKFB3	4051	-4955
PFKFB4	4317	-3233
PFKL	-975	-5964
PFKM	-311	-4441
PFKP	-1043	-2229
PGAM1	4394	-2347
PGD	4415	-2827
PGLS	2473	-2660
PGM1	2353	-4799
PGM2	4366	-1959
PGM2L1	1136	-1267
PGP	141	-3352
PGS1	4009	-5906
PHGDH	1068	-3513
PHKB	4019	-2130
PHKG2	510	-2649
PHOSPHO1	954	-430
PHYKPL	2335	1811
PI4K2A	-2091	-355
PI4K2B	-4718	-317
PI4KA	-785	-5
PI4KB	-1344	1292
PIAS4	1999	-3982
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3CG	646	-2045
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R4	-1199	-3425
PIK3R5	-695	514
PIKFYVE	1060	-2382
PIP4K2A	-691	1772
PIP4K2B	-2536	-6347
PIP4K2C	-4341	-5573
PIP5K1A	2498	-348
PIP5K1C	1156	-5383
PISD	4147	-4659
PITPNB	-2282	-4909
PITPNM1	2303	873
PITPNM2	-1470	2520
PITPNM3	-1010	1888
PKM	4363	-3076
PLA2G12A	2266	-5029
PLA2G15	4049	-3722
PLA2G4C	-846	-4912
PLA2G6	-4717	-3132
PLB1	4419	-5279
PLCB2	1724	-3046
PLCB3	4136	-5846
PLCD1	-3015	-2598
PLCD3	4365	-1196
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLD1	4274	-6058
PLD3	3212	1541
PLD6	-1122	2227
PLEKHA2	-429	-4384
PLEKHA3	-1556	-6547
PLEKHA6	-522	-2325
PLEKHA8	-918	-1764
PLIN2	3708	-96
PLIN3	4396	-3203
PMVK	1124	1829
PNP	3864	-4436
PNPLA2	4155	-5698
PNPLA6	2892	-3173
PNPLA7	-1992	-1431
PNPLA8	3378	-3836
PNPO	-2024	-5663
PODXL2	-3061	-1347
POLD1	42	-4975
POM121	-2762	-1787
POM121C	-2356	-4315
PON2	-1923	-4741
POR	3886	173
PPA1	618	1448
PPA2	695	-5450
PPARD	-1877	660
PPARGC1B	-1554	1840
PPCDC	-94	-1567
PPCS	2509	-4277
PPIP5K2	2485	-581
PPM1K	-4622	-1728
PPM1L	-937	-4324
PPOX	-4229	-232
PPP1CA	1462	550
PPP1CB	3008	1839
PPP1CC	2576	-754
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PPT1	4135	-4371
PPT2	-4186	-5624
PRKAB2	-2683	-1428
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAG2	612	-5033
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PRKCA	368	810
PRKD2	-3009	229
PSAP	2899	-4192
PSAT1	2773	-5212
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PSPH	2616	-2780
PSTK	-3666	-6128
PTDSS2	2314	-1185
PTEN	3857	-1100
PTGES2	-2149	-1462
PTGES3	1472	-1810
PTGR1	4198	-6711
PTGR2	408	-3930
PTPMT1	730	414
PTPN13	-3647	-6489
PTS	-591	-2642
PXMP2	1192	-2456
PYCR2	-716	-2919
PYGB	151	-5617
QDPR	-1512	-5226
QPRT	-4732	-4760
RAB14	3005	1334
RAB4A	3589	-5479
RAB5A	3055	-1686
RAE1	1948	-39
RAN	-2179	1257
RANBP2	-259	-4704
RAP1A	3142	323
RDH11	2587	-3361
RETSAT	155	-687
RFK	1157	-4148
RGL1	3304	1731
RIMKLB	-3946	-4779
RNLS	1290	-6149
RORA	-4632	2287
RPE	857	-4246
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRM1	-4262	-2309
RRM2	-61	-574
RRM2B	2862	-5757
RTEL1	-1345	-5696
RUFY1	2671	-4178
SACM1L	-3249	-1578
SAMD8	3344	-5347
SAMHD1	2635	-2016
SAR1B	2704	489
SARDH	-2982	-6693
SBF1	-3855	882
SC5D	-1057	-6658
SCAP	-1221	-3851
SCD	1444	-6126
SCLY	-2713	-875
SCO1	-3488	-1715
SCO2	-1280	-4657
SCP2	1626	-5793
SDC4	2765	1193
SDHA	-1683	-3404
SDHB	3282	-5123
SDHC	3854	-4120
SEC13	2286	-3749
SEC23A	3198	-5141
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEH1L	-1833	-1615
SEPHS2	3410	-2239
SERINC1	2281	-3455
SERINC3	2740	806
SERINC4	-374	1220
SERINC5	-1090	924
SGMS1	4072	-1653
SGPL1	1137	-2339
SGPP1	-4821	-5414
SHMT1	-219	-4063
SHMT2	-1506	-4020
SHPK	-770	1029
SIN3A	-3920	-4151
SIN3B	-1249	570
SLC16A1	1645	576
SLC16A3	4075	-6120
SLC19A1	4101	-1094
SLC19A2	-1227	-880
SLC22A5	2964	-5659
SLC23A1	-1296	-6481
SLC25A1	1894	-910
SLC25A11	3185	-419
SLC25A12	-1457	-2638
SLC25A13	-133	-6258
SLC25A15	-2936	-5407
SLC25A16	111	-2820
SLC25A17	-3961	-4326
SLC25A19	553	-1682
SLC25A20	1418	2245
SLC25A28	-811	1449
SLC25A32	-3272	-2299
SLC25A37	4397	-3601
SLC25A44	3398	729
SLC26A2	-879	-2627
SLC27A1	3788	-3528
SLC27A2	-1163	-6055
SLC27A3	-263	-1585
SLC27A5	-1091	-3060
SLC2A1	-4290	1930
SLC2A3	4226	-4757
SLC35B2	-3654	-2200
SLC35B3	2188	-554
SLC35D1	-2160	-2789
SLC36A4	3150	-4355
SLC37A1	-1807	-5144
SLC37A2	751	-5258
SLC37A4	-1887	-3038
SLC3A2	1969	-1667
SLC44A1	3856	2368
SLC44A2	878	2003
SLC5A5	-1629	-5772
SLC5A6	-1663	-2437
SLC7A5	1054	-6143
SLC9A1	3565	-753
SMPD1	349	-28
SMPD2	749	-918
SMPD3	-4815	2463
SORD	4036	-1871
SP1	3746	-3141
SPHK2	921	-2294
SPTLC1	3894	-5493
SPTLC2	3797	743
SPTLC3	640	1742
SPTSSA	1680	-5079
SQLE	1540	-5831
SRD5A1	3504	2146
SRD5A3	1437	442
SREBF1	2743	-4015
SREBF2	2838	-1852
SRM	-2279	753
ST3GAL1	-2411	1767
ST3GAL2	4018	-2686
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST3GAL6	2764	-5427
ST6GALNAC6	-4677	2144
STARD10	1789	-337
STARD3	1095	-5163
STARD3NL	3210	-4610
STARD4	-1209	-2360
STARD5	-906	-5368
STARD7	1166	-1506
STK11	709	-5709
STX1A	-1208	-2461
STXBP1	-1867	-5365
SUCLA2	3342	-1756
SUCLG1	2416	-1488
SUCLG2	-1799	964
SUMF1	4123	-5376
SUMF2	-4745	-3692
SURF1	1217	-4976
SYNJ1	2561	1501
SYNJ2	-2891	-6043
SYT5	2182	-5209
TACO1	1620	-5534
TALDO1	4405	-5245
TBL1XR1	1687	962
TBXAS1	3948	-6709
TECR	-3287	-274
THEM4	-4101	-6129
THTPA	-1038	-2617
TIAM2	-4202	-1035
TK1	1763	-3071
TK2	4267	-5591
TKT	4357	1166
TM7SF2	-2293	-1255
TMEM126B	-2839	-5677
TNFAIP8	-166	1226
TNFAIP8L1	-3602	-4062
TNFAIP8L2	2242	-249
TPI1	2797	-5027
TPK1	-977	-2721
TPMT	1593	-5097
TPR	-2272	-973
TPST1	4354	-2233
TPST2	2313	-2387
TRAP1	-4009	-3024
TRIB3	-1812	1669
TRMT112	184	-4666
TSPO	4360	-6553
TST	3459	2225
TSTD1	-2673	-1659
TXN	3798	284
TXN2	1737	-257
TXNRD1	3738	-4647
TYMP	886	-5857
TYMS	157	-1783
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2I	-239	233
UBIAD1	-3742	-245
UCK1	1821	-5092
UCK2	-3737	-5243
UCKL1	-1808	-5219
UCP2	312	331
UGCG	731	1914
UGDH	1440	-1951
UGP2	3140	-1297
UPP1	3926	-3833
UQCR11	2954	-6004
UQCRB	1355	-2785
UQCRC1	3444	-3413
UQCRC2	2318	1661
UQCRFS1	2550	618
UQCRH	3670	-6511
UQCRQ	961	-2641
UROD	1889	-4709
UROS	-4479	-4479
UST	-4490	-5056
VAC14	-30	-2381
VAMP2	-4530	-2770
VAPA	4183	-5592
VAPB	702	-6771
VDAC1	1532	-3624
VDR	3712	-3651
VKORC1	2857	557
WASL	91	-4742
XYLB	-3762	-2724
XYLT1	-2439	-5426
XYLT2	-1438	-3343
ZDHHC21	-1927	-3185

---

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

metric	value
setSize	147
pMANOVA	4.74e-11
p.adjustMANOVA	4.08e-09
s.dist	0.343
s.RNA	-0.283
s.meth	0.193
p.RNA	3.46e-09
p.meth	5.68e-05

Top 20 genes

Gene	RNA	meth
NOP14	-4072	2384
RRP9	-3599	2034
RPL3	-2866	2313
RPL23A	-3305	1843
NOL9	-3678	1426
EXOSC2	-4042	1269
RPL13A	-2702	1802
RPS11	-2281	2115
EXOSC8	-4307	1020
SNU13	-2197	1961
RPL32	-2060	1928
WDR75	-3459	1028
RPP38	-2173	1598
NOC4L	-1679	1990
RPS2	-1347	2392
RPL35	-2748	952
RPL4	-1061	2321
RPS10	-1744	1246
NOL6	-4033	526
EXOSC5	-1316	1591

Click HERE to show all gene set members

All member genes

	RNA	meth
BMS1	-4477	-2552
BYSL	-1313	-88
C1D	1236	510
CSNK1D	771	-1777
CSNK1E	-3694	-4750
DCAF13	-1724	-2001
DDX21	1019	760
DDX47	-4203	-3056
DDX49	1837	-4408
DDX52	161	-1954
DHX37	-2778	-312
DIS3	-1302	-762
EBNA1BP2	-1242	1600
ERI1	2175	130
EXOSC1	-309	-290
EXOSC10	-4357	-1580
EXOSC2	-4042	1269
EXOSC3	153	-2555
EXOSC4	3412	-4410
EXOSC5	-1316	1591
EXOSC6	-3569	545
EXOSC7	-3984	-4665
EXOSC8	-4307	1020
FAU	-129	-3862
FBL	-3630	-2611
FCF1	1658	-2675
FTSJ3	-1175	-670
GNL3	-2812	-1419
HEATR1	-3704	-1985
IMP3	-3221	99
IMP4	-3938	-2925
ISG20L2	1327	1893
KRR1	-2919	-6562
LTV1	-1261	-3205
MPHOSPH10	-2599	-57
MPHOSPH6	711	-5463
NCL	-3268	-2515
NIP7	-1832	-1760
NOB1	-3760	-1000
NOC4L	-1679	1990
NOL11	-3686	-2629
NOL12	1849	505
NOL6	-4033	526
NOL9	-3678	1426
NOP14	-4072	2384
NOP56	-4412	-523
NOP58	-3586	-2406
PDCD11	-4437	-2174
PELP1	-4029	-1579
PES1	-604	-3908
PNO1	-2216	-5495
PWP2	-312	681
RBM28	-4525	-685
RCL1	-272	-1421
RIOK1	-1124	-2098
RIOK2	305	-954
RIOK3	4000	-2443
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPP14	1011	-354
RPP21	-1592	-5256
RPP25	-2803	-5917
RPP30	-2733	-5522
RPP38	-2173	1598
RPP40	-1422	-1426
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRP1	-936	77
RRP7A	-853	-2961
RRP9	-3599	2034
SENP3	975	-1248
SNU13	-2197	1961
TBL3	-1028	994
TEX10	-3484	-1947
TSR1	-3373	-3041
UBA52	344	752
UTP15	-3865	-2796
UTP18	1954	-3819
UTP20	-3801	-1372
UTP3	-883	-3665
UTP6	-1353	-1904
WDR12	2015	706
WDR18	-707	-2042
WDR3	-2064	-5710
WDR36	-1144	-2277
WDR43	-2465	-4225
WDR75	-3459	1028
XRN2	4368	-5589

---

---

Post-translational protein modification

Post-translational protein modification

metric	value
setSize	889
pMANOVA	9.73e-11
p.adjustMANOVA	7.78e-09
s.dist	0.133
s.RNA	0.12
s.meth	0.0588
p.RNA	4.08e-09
p.meth	0.00386

Top 20 genes

Gene	RNA	meth
FURIN	4236	2351
SOCS3	4414	2178
SIAH2	3939	2185
PHC2	4201	1830
KDELR1	4237	1780
FKBP8	3962	1784
RNF146	3919	1789
RNF123	2894	2363
TMED7	3495	1939
CUL3	2907	2054
TUBB4B	3154	1856
DAD1	2384	2452
PPP6C	2885	2020
NOD2	3786	1528
GLB1	3936	1368
PSMA7	3060	1752
NSMCE1	2411	2210
PSMD1	3121	1660
TAF10	3073	1606
RHOA	3688	1313

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ACTB	4172	-4515
ACTL6A	-2395	-4851
ACTR10	3334	-1291
ACTR1A	3003	-1
ACTR5	-4180	-3829
ACTR8	-1484	-5628
ADAM10	3964	976
ADAMTS10	-4023	-5260
ADAMTS13	-1254	958
ADAMTS17	-1102	463
ADAMTS6	-2140	1076
ADAMTSL4	3240	1378
ADAMTSL5	-2562	-6404
ADRB2	-4638	-3531
ADRM1	1393	589
AGBL2	-3088	-5272
AGBL3	-2956	-646
AGBL5	1159	-3128
AGTPBP1	3771	-1941
ALG10	-2612	-346
ALG10B	-2684	966
ALG11	-1076	-549
ALG12	852	-1300
ALG14	2290	1103
ALG2	-422	-625
ALG3	-387	-2680
ALG5	-216	-2175
ALG6	508	-4449
ALG8	-1089	-3591
ALG9	-3466	-1148
AMDHD2	-3916	539
AMFR	3220	-6742
ANK1	4083	-4221
ANK3	-1508	-6563
ANKRD28	-1964	-5108
ANKRD9	3685	-635
ANO8	2476	384
APC	1087	-4775
APLP2	4302	-3465
APP	4212	-5300
ARCN1	2206	-1676
ARF1	4190	-6686
ARF3	3423	-1912
ARF4	4255	-3280
ARF5	3536	-4789
ARFGAP1	-583	1688
ARFGAP3	1308	-5386
ARRB1	659	-6363
ARRB2	3858	-2243
ARSA	1185	-3099
ARSB	3173	-5722
ARSG	-1451	152
ARSK	-4241	-54
ASB1	1098	1900
ASB13	1125	-5265
ASB2	-4713	-2230
ASB6	-835	-6098
ASB7	2567	-4653
ASB8	1852	998
ASXL1	-3667	-4360
ASXL2	585	-1790
ATXN3	502	1703
ATXN7	-505	759
AURKA	1188	-385
AURKB	309	-889
AXIN1	-3733	-5655
AXIN2	-2404	-4719
B3GALNT2	-5	-1560
B3GNT2	2380	-1684
B3GNT7	-4852	-6593
B3GNT8	4186	-6681
B3GNTL1	2141	-2656
B4GALT1	1562	-160
B4GALT2	-1893	1307
B4GALT3	-3906	-4680
B4GALT4	185	-1422
B4GALT5	4092	52
B4GALT6	-3085	-6484
B4GAT1	-1747	451
BABAM1	-297	-1937
BAP1	357	1999
BARD1	-1018	-2910
BCL10	2346	-3261
BECN1	2625	459
BET1	-202	-4482
BET1L	-2386	332
BIRC2	1750	-1862
BIRC3	-4025	-2320
BIRC5	1432	-84
BLM	-1434	-2909
BMI1	-3450	-6383
BRCA1	2537	-4609
BTBD1	718	-5321
BTBD6	-1611	-136
BTRC	-1491	-2427
C1GALT1	-1289	-3509
CALM1	-614	-5019
CALR	2620	-3753
CALU	3485	1252
CAND1	-2049	-421
CANX	2138	-4839
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CASP8AP2	-3731	231
CBX4	706	-5288
CBX8	2136	2207
CCNA2	521	-1132
CCNF	-3306	-4258
CD55	4233	-3923
CD59	2365	-6024
CDC20	1435	116
CDC25A	945	-1711
CDC34	3982	-2454
CDC73	1921	-2092
CDCA8	-556	472
CDK1	454	-4215
CDKN2A	-1623	-4511
CHD3	-3299	422
CHST10	-4624	-5927
CISH	1861	1748
CKAP4	4371	-6717
CLSPN	1301	-1524
CMAS	4029	-2712
CNIH1	3446	-6699
COG1	-4741	-3663
COG2	-2655	-6132
COG3	-1593	-5701
COG4	1	-984
COG5	-985	-1864
COG6	-1803	-358
COG7	1546	-4196
COG8	-131	1846
COMMD1	2360	-4720
COMMD10	1547	171
COMMD2	1077	782
COMMD3	-436	-6772
COMMD4	-1392	-5750
COMMD5	2159	-1140
COMMD6	-350	-2702
COMMD7	2028	2040
COMMD8	3189	187
COMMD9	3497	-4811
COPA	3748	1056
COPB1	3188	-1329
COPB2	3530	-1501
COPE	2941	213
COPS2	2465	896
COPS3	2406	-2950
COPS4	587	-3507
COPS5	1597	-1617
COPS6	516	-866
COPS7A	2748	-565
COPS7B	-3523	538
COPS8	-3027	-4126
COPZ1	1431	-5051
COPZ2	-4133	1305
CPM	2884	-4667
CREBBP	1169	-5804
CSF1	-605	-5924
CSNK1D	771	-1777
CTBP1	-2048	2394
CTR9	1123	-5535
CTSA	4423	-4847
CTSC	817	1561
CTSZ	4137	-6765
CUL1	-4385	-5146
CUL2	821	-1212
CUL3	2907	2054
CUL4A	-1453	1876
CUL5	269	-3077
CUL7	-1000	-2524
CUL9	-1822	-5978
CYLD	-3106	1406
DAD1	2384	2452
DAG1	-2435	-146
DAXX	-3887	-450
DCAF10	1871	1341
DCAF11	-733	-1493
DCAF13	-1724	-2001
DCAF16	-4513	-4367
DCAF17	-4276	986
DCAF4	-4183	1739
DCAF5	-3478	-3273
DCAF6	3765	-2743
DCAF7	-500	683
DCAF8	-3470	-439
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DCUN1D2	-1465	318
DCUN1D3	1573	-429
DCUN1D4	-3492	-2024
DCUN1D5	280	-5390
DDA1	1040	606
DDB2	-4468	-561
DDX17	-1811	206
DDX5	-3458	1288
DDX58	-4687	-1002
DERL1	-3142	123
DERL2	1003	-2287
DHDDS	-625	-4895
DHPS	160	-149
DNAJC24	-3992	1293
DNAJC3	3833	-2353
DNMT1	-4819	1294
DNMT3A	-845	-6002
DNMT3B	1560	1185
DOHH	-508	-1316
DOLK	-1093	-2245
DOLPP1	930	-914
DPAGT1	690	650
DPH1	-4309	-3723
DPH2	-3898	-486
DPH3	3453	-3670
DPH5	38	1156
DPH7	-3935	-5720
DPM1	488	-2366
DPM2	1768	-1939
DPM3	827	-2637
DTL	123	-5529
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
EDEM1	-41	1523
EDEM2	4014	-3093
EEF1A1	-1543	720
EEF2	93	2127
EEF2KMT	-3526	2078
EID3	-4544	-328
EIF5A	181	-363
ENGASE	-2201	-5741
EP300	2504	-4509
EPAS1	3555	535
ERCC8	1053	-5536
ETFB	3405	-3921
FBXL12	-400	292
FBXL14	-1870	2358
FBXL15	1650	-4502
FBXL16	-2110	-4011
FBXL18	1128	-5248
FBXL19	3985	-6239
FBXL20	1825	-993
FBXL22	-3236	562
FBXL3	329	-4101
FBXL4	2160	-5130
FBXL5	4384	-6189
FBXL8	1405	-479
FBXO11	2807	-500
FBXO15	-347	647
FBXO21	-4031	-933
FBXO22	-1110	1132
FBXO30	1752	-609
FBXO31	-4648	480
FBXO32	-4006	-1875
FBXO4	-4627	-4056
FBXO6	-687	234
FBXO7	3287	-3059
FBXO9	4390	-3674
FBXW11	2542	-6747
FBXW2	2739	-3711
FBXW4	-4464	1993
FBXW5	75	-194
FBXW7	-2109	-5428
FBXW8	-3566	-2504
FEM1A	603	-82
FEM1B	1628	1880
FKBP8	3962	1784
FN3KRP	-4248	1195
FOXK1	-1549	-5199
FOXK2	1134	-6253
FPGT	3174	-2826
FSTL3	4347	88
FUCA1	3251	-5579
FUCA2	3675	-427
FUOM	-1587	-5803
FURIN	4236	2351
FUT8	-3435	-2455
GALNT10	-956	-6074
GALNT11	-943	-3318
GALNT12	-3462	-5876
GALNT2	4082	-5164
GALNT3	633	-2941
GALNT4	3071	-180
GALNT6	-254	-6156
GALNT7	3747	57
GAN	-427	-2479
GANAB	-316	-3501
GATA3	-4787	1861
GBF1	-1292	-120
GCNT1	3825	179
GFPT1	-2050	-2828
GGCX	2025	-3236
GLB1	3936	1368
GMDS	1860	-1375
GMPPA	1360	-4201
GMPPB	-2292	1238
GNE	-1601	-4921
GNPNAT1	-3357	-2849
GOLGA2	2510	1847
GOLGB1	-1656	-3196
GOLM1	-2215	-6094
GORASP1	2763	-2178
GOSR1	-51	-3152
GOSR2	-462	1643
GPAA1	2425	-843
GPS1	-1373	-6247
HDAC1	124	-1016
HDAC2	2158	-46
HDAC4	4171	-3817
HDAC7	2424	-4900
HGS	1660	2123
HIF1A	3192	-3349
HIPK2	2508	-1520
HLA-A	-768	-5991
HLA-B	212	1015
HNRNPC	2584	-1112
HNRNPK	3313	-2386
HSP90B1	655	-1371
ICMT	-247	-71
IDE	2999	-777
IFIH1	-4410	-4856
IGFBP4	-2521	-6569
IKBKE	1764	2086
INCENP	-1866	-2850
ING2	1592	-2115
INO80	-2992	-74
INO80B	-595	-3700
INO80C	2539	-3246
INO80D	-1596	-869
INO80E	-2468	-2832
JOSD1	94	-3051
JOSD2	3573	-957
KAT2A	-3767	-5050
KAT2B	-704	-1588
KBTBD6	-1069	327
KBTBD7	2705	-1326
KBTBD8	-1256	-4094
KCTD6	1605	886
KCTD7	-4104	-602
KDELR1	4237	1780
KDELR2	3293	-2980
KDM1B	1845	1468
KEAP1	1872	-2872
KIN	1226	617
KLHL11	-1896	186
KLHL2	4277	-4276
KLHL20	-4411	-2781
KLHL21	1908	-1243
KLHL22	-4140	-899
KLHL25	-3758	-464
KLHL5	1950	-4208
KTN1	1101	-2404
L3MBTL2	-3980	-4114
LAMB2	156	-2207
LEO1	26	791
LGALS1	4174	-79
LMAN1	-3951	596
LMAN2	3064	-2497
LMAN2L	2953	-1590
LMO7	-3257	2419
LRR1	-2547	1362
LRRC41	3306	404
LTBP1	3553	-4651
LYPD3	-2352	-4231
MAN1A1	3539	-447
MAN1A2	-601	-1465
MAN1B1	-1489	2249
MAN1C1	-2013	-1205
MAN2A1	-406	-4486
MAN2A2	2762	-5172
MANEA	-207	172
MAP3K7	780	-2089
MAT2B	-3867	-2153
MAVS	3095	-4500
MBD1	632	-1177
MBD5	845	-6395
MBD6	3372	-5542
MBTPS1	951	-398
MCFD2	3037	-158
MCRS1	-2811	1266
MDC1	-4696	-902
MDM2	1471	-1318
MDM4	-377	-2440
MEN1	-2763	-2311
METTL21A	1211	1437
METTL22	1981	2176
MFGE8	1274	-527
MGAT1	2494	1169
MGAT2	519	-1666
MGAT4A	-1692	-2254
MGAT4B	3991	-6439
MGAT5	-941	-5572
MIA3	-1970	-3428
MLEC	742	953
MOGS	-919	-2356
MPDU1	3420	-1260
MPI	-3671	-5890
MUC1	2718	-5557
MUC12	-4050	-5807
MUC5B	-1387	2353
MUL1	997	-3003
MVD	-1820	1954
MYSM1	-2408	-616
NAE1	-4047	897
NAGK	1045	-5552
NANP	-3397	-585
NANS	3512	529
NAPA	425	-4125
NAPB	-827	471
NAPG	1477	-97
NCOA2	352	1407
NCOR2	3521	-4281
NDC1	-4771	-5228
NEDD8	2723	-1600
NEGR1	461	-6424
NEU1	4191	-3878
NEU3	-1129	-1409
NEURL2	-951	2421
NFKB2	-279	388
NFKBIA	2855	1159
NFRKB	-821	-3238
NGLY1	-1111	-236
NICN1	-560	-2869
NLRP3	4033	-6357
NOD1	-4838	-5170
NOD2	3786	1528
NOP58	-3586	-2406
NPL	4422	-6573
NR1H2	3254	-1471
NR1H3	-1011	-2305
NR1I2	-1260	-4903
NR2C1	-3442	-1463
NR3C1	190	-2420
NR3C2	-3730	324
NR4A2	-494	1416
NSMCE1	2411	2210
NSMCE2	2356	-6425
NSMCE4A	-4080	-4495
NTNG2	2209	903
NUB1	-4715	1450
NUCB1	4098	-5498
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
NUS1	3489	-9
OS9	4053	-975
OTUB1	435	-5956
OTUD3	-3909	-1582
OTUD7B	-4748	-2644
OTULIN	-222	1535
P4HB	3824	-1549
PAF1	1195	-5838
PARK7	2668	-821
PARP1	-4461	-5521
PCNA	-1864	-511
PDIA3	1468	1466
PDIA6	2350	1837
PEX10	-2097	1348
PEX12	-2964	-2164
PEX13	183	-1839
PEX14	1057	-3892
PEX2	988	-5892
PEX5	1499	-6491
PGAP1	-2996	-660
PGM3	-250	1964
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
PIAS1	3206	-2534
PIAS2	-2497	-2314
PIAS3	-401	1855
PIAS4	1999	-3982
PIGC	-452	-2121
PIGF	2774	-1570
PIGH	-3288	-1358
PIGK	-1872	-2040
PIGL	-4531	-1793
PIGM	21	-4141
PIGN	581	-3172
PIGO	-3071	-2601
PIGP	-1561	-3043
PIGQ	545	-2760
PIGS	2975	-749
PIGT	320	-1299
PIGU	-3180	-504
PIGV	-538	-2037
PIGW	-4510	1896
PIGX	2109	-5421
PLAUR	3843	-6237
PML	-3036	549
PMM1	1492	-1060
PMM2	439	-2687
PNPLA2	4155	-5698
POFUT2	-3932	1983
POLB	-2514	-1516
POM121	-2762	-1787
POM121C	-2356	-4315
POMGNT1	-4641	-826
POMGNT2	-1228	-6177
POMK	-580	-1346
POMT1	-2923	1390
POMT2	195	-669
PPP6C	2885	2020
PPP6R1	2037	-1276
PPP6R3	1102	-3726
PRKCSH	2022	-3007
PRKDC	-3663	1316
PRMT3	535	-372
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTEN	3857	-1100
PTP4A2	860	2110
PTRH2	1710	-4375
PUM2	-610	-801
QSOX1	4308	-1087
RAB10	4097	-3437
RAB11A	3974	-2965
RAB11B	1610	-387
RAB12	-282	-1635
RAB14	3005	1334
RAB18	3484	-1995
RAB19	1584	-3370
RAB1A	4185	-1703
RAB1B	3794	-264
RAB22A	-1259	-3947
RAB23	361	-2847
RAB24	2077	-3725
RAB26	-1325	2425
RAB27A	3850	-1181
RAB29	-3770	282
RAB2A	3902	-2810
RAB2B	-3146	-557
RAB30	-3074	-2803
RAB33B	3182	547
RAB34	3792	-3968
RAB35	1406	780
RAB37	-4598	-5384
RAB3A	3705	-1080
RAB3D	4269	-6515
RAB40B	-4316	1177
RAB40C	3744	8
RAB43	2675	1154
RAB4A	3589	-5479
RAB4B	1059	1318
RAB5A	3055	-1686
RAB5B	2837	-2055
RAB5C	3954	-1152
RAB6A	3692	-311
RAB7A	4011	-5570
RAB8A	1340	-1289
RAB8B	2729	79
RABGGTA	-728	1696
RABGGTB	-1598	2306
RAD18	-4589	812
RAD21	534	702
RAD23A	2724	-3621
RAD23B	4100	-3906
RAD52	-321	-2399
RAE1	1948	-39
RANBP2	-259	-4704
RANGAP1	-4514	1644
RARA	2591	-5249
RBBP5	325	-779
RBX1	1413	-3241
RCE1	-1411	-282
RCN1	-4073	-2128
RECK	-2783	-4325
RELA	-541	2085
RFT1	1565	147
RHOA	3688	1313
RHOT1	4331	-5271
RING1	-1202	-1490
RNF103	-1377	-2036
RNF123	2894	2363
RNF135	3870	-6458
RNF139	866	354
RNF146	3919	1789
RNF152	1025	-1925
RNF168	-1270	1626
RNF181	2435	312
RNF185	2714	-2775
RNF2	1210	-1936
RNF20	2282	-799
RNF40	2784	-5137
RNF5	-2030	-4625
RNF7	3537	-1943
RORA	-4632	2287
RPA1	-4680	-2495
RPN1	3560	-2841
RPN2	3036	-688
RPS2	-1347	2392
RPS27A	-2186	-2138
RRAGA	2580	-1657
RTF1	1224	-4613
RTN4RL2	2945	-6031
RUVBL1	-2967	256
RWDD3	-86	-4374
SAE1	-2832	2410
SAFB	839	-3542
SAR1B	2704	489
SATB1	-2483	-1979
SATB2	2725	-6456
SCMH1	-1695	1397
SEC13	2286	-3749
SEC16A	1717	-1722
SEC22A	-1547	696
SEC22C	-1274	1879
SEC23A	3198	-5141
SEC23IP	-149	-38
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SEH1L	-1833	-1615
SEL1L	2854	-2307
SENP1	-2676	-1254
SENP2	1427	-382
SENP5	-2145	261
SENP8	1020	-1816
SHISA5	398	1884
SHPRH	-2810	-353
SIAH2	3939	2185
SIN3A	-3920	-4151
SKP1	1561	-2290
SKP2	-2780	-1566
SLC17A5	1920	-3631
SLC35A1	3137	-4021
SLC35C1	881	-5366
SMAD1	3832	-3272
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMAD7	-4655	-4450
SMC3	-592	-1642
SMC5	-2312	-2372
SMC6	-1285	1981
SMURF2	-3700	-3048
SOCS2	-769	378
SOCS3	4414	2178
SOCS5	1047	-4583
SP100	1527	-769
SP3	2154	-3116
SPON2	-4845	1081
SPSB1	772	-3865
SPSB3	-1841	-4699
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SRD5A3	1437	442
ST3GAL1	-2411	1767
ST3GAL2	4018	-2686
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST3GAL5	-4489	1507
ST3GAL6	2764	-5427
ST6GAL1	-4644	1948
ST6GALNAC3	4287	145
ST6GALNAC4	-268	-5981
ST6GALNAC6	-4677	2144
ST8SIA1	-2619	-2246
ST8SIA4	3717	-3013
STAG1	-2003	-863
STAM	404	770
STAM2	2488	-2181
STAMBP	511	-93
STAMBPL1	-3745	-5600
STT3A	1453	-4222
STX17	-4112	-4247
STX5	3070	-1823
SUDS3	1670	-1851
SUMF1	4123	-5376
SUMF2	-4745	-3692
SUMO1	2937	-3986
SUMO3	2962	-5577
SYVN1	322	-5153
TAF10	3073	1606
TBC1D20	-16	-5205
TDG	2829	621
TFPT	2063	-333
TGFA	4154	-3020
TGFB1	1971	-6
TGFBR1	507	-6163
TGFBR2	1344	-5224
TGOLN2	3932	-2836
THRA	-1980	-2798
TMED10	104	604
TMED2	2437	-3656
TMED3	893	-2936
TMED7	3495	1939
TMED9	3079	-1992
TMEM115	2179	-703
TMEM129	1361	1624
TNFAIP3	-4190	-785
TNIP1	3834	-2256
TNIP2	2191	-5726
TNKS	-3013	-1583
TNKS2	-164	-449
TOMM20	-819	2451
TOP1	3349	-2610
TOP2A	944	192
TOP2B	-813	-3244
TOPORS	925	462
TP53	-4078	-739
TP53BP1	-4059	-2967
TPGS1	1578	1697
TPGS2	-959	-4475
TPR	-2272	-973
TPST1	4354	-2233
TPST2	2313	-2387
TRAF2	-4465	-1442
TRAF3	-1622	2379
TRAF6	-81	-6118
TRAPPC1	3480	-3029
TRAPPC10	-3321	2388
TRAPPC2L	-690	1441
TRAPPC3	3050	-2853
TRAPPC4	-2164	-3231
TRAPPC5	2001	-5629
TRAPPC6A	-4070	1765
TRAPPC6B	1486	-662
TRAPPC9	2076	-4354
TRIM13	-684	497
TRIM25	3724	-3718
TRIM27	3711	-1744
TRIM28	-1482	1191
TRRAP	-2130	1860
TSTA3	2570	1496
TTL	-1190	-4334
TTLL1	-2535	-5225
TTLL11	-1575	-5747
TTLL12	2083	1569
TTLL3	-711	-2560
TTLL4	3507	-4814
TTLL5	-1229	-3569
TTLL7	2590	-1018
TUBA1A	3204	-4767
TUBA1B	2167	-1058
TUBA1C	3101	-150
TUBB2A	4013	-4771
TUBB4B	3154	1856
UAP1	-4800	-3110
UBA2	-2047	1399
UBA3	3408	-2122
UBA52	344	752
UBA6	1181	1251
UBB	2801	-1321
UBC	1599	-2568
UBE2B	3032	-2486
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2E3	1918	-5759
UBE2F	3224	-3774
UBE2G1	1879	-1626
UBE2G2	-2597	-3560
UBE2H	3435	-1867
UBE2I	-239	233
UBE2J2	3785	-368
UBE2K	2853	1379
UBE2L3	3307	-3496
UBE2M	3295	-3585
UBE2N	616	1127
UBE2Q2	-4499	-4146
UBE2R2	3891	-3277
UBE2S	1785	2449
UBE2T	-2970	-2989
UBE2V2	965	-3487
UBE2W	3511	-618
UBE2Z	-4161	-4538
UBXN1	597	-2222
UBXN7	496	-1320
UCHL3	630	-752
UCHL5	-2631	-6243
UGGT1	1936	-3498
UHRF2	-3471	-1716
UIMC1	4301	-3114
USO1	1479	1196
USP10	3332	-5328
USP12	1891	-4528
USP13	-2115	-667
USP14	-1608	-5011
USP15	2399	686
USP16	-2668	1533
USP18	-4831	-2616
USP19	-150	492
USP20	-4218	2238
USP21	-2098	-3841
USP22	2814	-3087
USP24	-4315	1979
USP25	49	1721
USP28	-4855	-3970
USP3	3931	-267
USP30	270	-2625
USP33	-260	-5582
USP34	-296	-4481
USP4	3431	-5610
USP42	-4398	-3364
USP44	-2437	-4859
USP47	-1178	-3304
USP48	1603	-4606
USP49	853	1872
USP5	-1900	-173
USP7	2617	-2216
USP8	2599	-424
VCP	2927	-2411
VCPIP1	-92	-476
VCPKMT	96	-631
VDAC1	1532	-3624
VDAC3	150	1058
VDR	3712	-3651
VHL	1285	1389
WAC	2039	53
WDR20	-345	-4288
WDR48	-4493	-5481
WDR5	39	-5613
WDR61	28	-4752
WDTC1	2893	-205
WFS1	-3419	409
WRN	-4674	-2102
WSB1	3452	-637
WSB2	3335	-6513
XPC	-4425	-402
XRCC4	2832	-3706
YKT6	2009	-3331
YOD1	3305	-556
YY1	169	-5165
ZBTB16	391	2289
ZNF131	-4182	-423

---

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

metric	value
setSize	154
pMANOVA	1.18e-10
p.adjustMANOVA	8.81e-09
s.dist	0.328
s.RNA	-0.275
s.meth	0.18
p.RNA	4.4e-09
p.meth	0.000129

Top 20 genes

Gene	RNA	meth
NOP14	-4072	2384
RRP9	-3599	2034
RPL3	-2866	2313
RPL23A	-3305	1843
NOL9	-3678	1426
EXOSC2	-4042	1269
RPL13A	-2702	1802
RPS11	-2281	2115
EXOSC8	-4307	1020
SNU13	-2197	1961
RPL32	-2060	1928
WDR75	-3459	1028
RPP38	-2173	1598
NOC4L	-1679	1990
RPS2	-1347	2392
RPL35	-2748	952
RPL4	-1061	2321
RPS10	-1744	1246
NOL6	-4033	526
EXOSC5	-1316	1591

Click HERE to show all gene set members

All member genes

	RNA	meth
BMS1	-4477	-2552
BYSL	-1313	-88
C1D	1236	510
CSNK1D	771	-1777
CSNK1E	-3694	-4750
DCAF13	-1724	-2001
DDX21	1019	760
DDX47	-4203	-3056
DDX49	1837	-4408
DDX52	161	-1954
DHX37	-2778	-312
DIS3	-1302	-762
EBNA1BP2	-1242	1600
ERI1	2175	130
EXOSC1	-309	-290
EXOSC10	-4357	-1580
EXOSC2	-4042	1269
EXOSC3	153	-2555
EXOSC4	3412	-4410
EXOSC5	-1316	1591
EXOSC6	-3569	545
EXOSC7	-3984	-4665
EXOSC8	-4307	1020
FAU	-129	-3862
FBL	-3630	-2611
FCF1	1658	-2675
FTSJ3	-1175	-670
GAR1	-2237	-4416
GNL3	-2812	-1419
HEATR1	-3704	-1985
IMP3	-3221	99
IMP4	-3938	-2925
ISG20L2	1327	1893
KRR1	-2919	-6562
LTV1	-1261	-3205
MPHOSPH10	-2599	-57
MPHOSPH6	711	-5463
NCL	-3268	-2515
NHP2	-1035	-260
NIP7	-1832	-1760
NOB1	-3760	-1000
NOC4L	-1679	1990
NOL11	-3686	-2629
NOL12	1849	505
NOL6	-4033	526
NOL9	-3678	1426
NOP10	3831	-3526
NOP14	-4072	2384
NOP2	-3314	-2438
NOP56	-4412	-523
NOP58	-3586	-2406
PDCD11	-4437	-2174
PELP1	-4029	-1579
PES1	-604	-3908
PNO1	-2216	-5495
PWP2	-312	681
RBM28	-4525	-685
RCL1	-272	-1421
RIOK1	-1124	-2098
RIOK2	305	-954
RIOK3	4000	-2443
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPP14	1011	-354
RPP21	-1592	-5256
RPP25	-2803	-5917
RPP30	-2733	-5522
RPP38	-2173	1598
RPP40	-1422	-1426
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRP1	-936	77
RRP7A	-853	-2961
RRP9	-3599	2034
SENP3	975	-1248
SNU13	-2197	1961
TBL3	-1028	994
TEX10	-3484	-1947
THUMPD1	-3487	-4292
TRMT112	184	-4666
TSR1	-3373	-3041
TSR3	1352	1167
UBA52	344	752
UTP15	-3865	-2796
UTP18	1954	-3819
UTP20	-3801	-1372
UTP3	-883	-3665
UTP6	-1353	-1904
WDR12	2015	706
WDR18	-707	-2042
WDR3	-2064	-5710
WDR36	-1144	-2277
WDR43	-2465	-4225
WDR75	-3459	1028
XRN2	4368	-5589

---

---

Gene expression (Transcription)

Gene expression (Transcription)

metric	value
setSize	1007
pMANOVA	1.58e-10
p.adjustMANOVA	1.1e-08
s.dist	0.128
s.RNA	-0.128
s.meth	-0.00861
p.RNA	3.06e-11
p.meth	0.655

Top 20 genes

Gene	RNA	meth
MOV10	-4691	-6449
ZNF530	-4642	-6175
ZKSCAN8	-4216	-6728
ZNF568	-4424	-6314
AUTS2	-4756	-5652
ZNF528	-4094	-6459
ZNF354C	-4069	-6378
CCND2	-4504	-5700
ZNF211	-4244	-6023
ZNF620	-4587	-5485
ERBB2	-4860	-5145
NDC1	-4771	-5228
ZNF549	-4440	-5587
ZNF43	-4605	-5370
CNOT6L	-4344	-5686
PARP1	-4461	-5521
ZNF584	-4271	-5742
ZNF70	-4592	-5340
PIP4K2C	-4341	-5573
ZNF287	-4733	-5090

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ABL1	69	-4891
ACTB	4172	-4515
ACTL6A	-2395	-4851
AEBP2	-3157	-1677
AFF4	427	-5010
AGO1	2205	1997
AGO2	983	2447
AGO3	-318	-6442
AKT1	1248	-1942
AKT2	108	-141
ALYREF	2121	-4902
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC15	4157	-1379
ANAPC16	-645	-4507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
APAF1	4182	-2104
ARID1A	1819	-6716
ARID1B	-1691	1093
ARID2	-1177	-657
ARID3A	3916	-4723
ARID4B	16	-1226
ASH2L	2381	-3791
ATAD2	-4041	-1835
ATM	-4028	202
ATR	-3783	970
ATRIP	-4340	-2737
ATXN3	502	1703
AURKA	1188	-385
AURKB	309	-889
AUTS2	-4756	-5652
AXIN1	-3733	-5655
BANP	208	-4163
BARD1	-1018	-2910
BAX	2386	-3623
BAZ1B	-1317	-691
BAZ2A	-673	-5766
BBC3	-2642	-3845
BCDIN3D	-1077	1299
BCL2L11	3144	1781
BCL6	4305	-299
BDP1	-2335	-3715
BID	2427	844
BIRC5	1432	-84
BLM	-1434	-2909
BMI1	-3450	-6383
BNIP3L	4325	-851
BRCA1	2537	-4609
BRD1	-4083	2465
BRD2	-3312	1256
BRD7	-12	-5008
BRF1	-3058	-3436
BRF2	-246	-279
BRIP1	-4545	-2323
BRPF1	-2320	89
BRPF3	-2021	-937
BTG1	-1579	2084
BTG2	922	-1900
CALM1	-614	-5019
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAMK4	-3176	1482
CASC3	2017	-2580
CASP1	1434	-1448
CASP10	-1033	-6612
CASP6	-862	-4898
CAT	4221	-3922
CAV1	584	-2432
CBFB	680	-3766
CBX3	1810	-859
CBX4	706	-5288
CBX6	1438	-3511
CBX8	2136	2207
CCNA2	521	-1132
CCNB1	144	1492
CCNC	596	-1138
CCND1	-2169	-6213
CCND2	-4504	-5700
CCND3	3252	905
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCNG1	1839	131
CCNG2	2810	-3720
CCNH	249	-3754
CCNK	942	-6142
CCNT1	-3342	1773
CD3EAP	-240	-738
CDC16	-1863	-4152
CDC23	-4319	-707
CDC25C	1885	-2877
CDC40	2856	2242
CDC7	-2607	-202
CDC73	1921	-2092
CDK1	454	-4215
CDK12	-417	-805
CDK13	-2893	-700
CDK2	-1524	1018
CDK4	-4195	-1295
CDK5	3942	-506
CDK5R1	-356	-2113
CDK6	-1983	-2864
CDK7	2020	275
CDK8	-597	-5509
CDK9	-1184	1524
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDKN2A	-1623	-4511
CEBPB	3621	-5089
CENPJ	-4301	-838
CHD3	-3299	422
CHD4	-1372	-4634
CHEK1	-752	-211
CHEK2	-1306	-2709
CITED2	2650	-104
CITED4	3297	-701
CLP1	2775	-1417
CNOT1	-1283	-4543
CNOT10	-800	-361
CNOT11	661	-2236
CNOT3	2060	565
CNOT4	-392	-3064
CNOT6	1776	-3728
CNOT6L	-4344	-5686
CNOT7	-1157	349
CNOT8	3743	-2054
COX11	-4162	-789
COX14	-463	-3835
COX16	66	-1160
COX19	-2202	-4047
COX20	-1528	-4841
COX4I1	1505	-5506
COX5A	2520	-2944
COX5B	2572	382
COX6A1	1958	-961
COX6B1	2260	-2634
COX6C	228	-1411
COX7A2L	3430	-2476
COX7C	178	-4071
COX8A	2789	-1258
CPSF1	-1130	-6284
CPSF2	3479	-3164
CPSF3	2696	-4860
CPSF4	-3362	134
CRADD	2031	-4017
CRCP	1826	-577
CREB1	-423	-672
CREBBP	1169	-5804
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CSTF1	-1905	2021
CTDP1	2551	1112
CTLA4	-3873	2506
CTNNB1	2647	-1691
CTR9	1123	-5535
CTSL	1667	-6671
CTSV	-848	-5834
CUL1	-4385	-5146
CYCS	-386	-3927
DAXX	-3887	-450
DDB2	-4468	-561
DDIT3	1835	-3177
DDIT4	-502	-2588
DDX21	1019	760
DEK	854	1060
DGCR8	-4603	-495
DICER1	3695	1032
DNA2	-871	-2087
DNMT1	-4819	1294
DNMT3A	-845	-6002
DNMT3B	1560	1185
DPY30	1310	-1010
DYRK2	-4396	-3036
E2F1	2654	-1005
E2F4	2607	-172
E2F5	-2781	-2646
E2F6	-1495	-2466
E2F7	-1816	-1622
E2F8	926	-4363
EAF1	2180	-4156
EED	-3277	-1174
EHMT1	-2969	-1697
EHMT2	-2882	-1059
EIF4A3	3171	-3850
ELF1	515	-1733
ELF2	847	-3373
ELL	1902	574
ELL2	3490	-3578
ELL3	20	-2569
EP300	2504	-4509
EPC1	-3604	-2797
ERBB2	-4860	-5145
ERCC2	1202	-594
ERCC3	-2537	969
ERCC6	-3947	-4037
ESR2	-3196	-2661
ESRRA	2370	-2927
EXO1	-481	-3123
EZH2	-3517	-20
FANCC	-4387	-3902
FANCD2	-4393	1778
FANCI	-4672	-4622
FAS	1270	-5824
FBXO32	-4006	-1875
FBXW7	-2109	-5428
FIP1L1	-2679	-2274
FKBP5	4105	-5653
FOS	2486	2149
FOXO1	-3171	-5036
FOXO3	3983	711
FYTTD1	-1788	1459
FZR1	-666	-758
GADD45A	4281	-2249
GATA3	-4787	1861
GATAD2A	1016	-256
GATAD2B	-535	-2871
GLS	-4521	-4781
GPAM	-3559	-4630
GPI	2523	-2211
GPS2	-290	-857
GSK3B	2793	736
GSR	4279	-4724
GTF2A1	884	271
GTF2A2	3083	-1036
GTF2B	1223	-3218
GTF2E2	2305	-184
GTF2F1	1892	-1723
GTF2F2	2127	-2885
GTF2H3	-664	1025
GTF2H4	-874	-2761
GTF2H5	1343	691
GTF3A	-2460	-2426
GTF3C1	-2988	2022
GTF3C2	-3234	-872
GTF3C3	-676	1945
GTF3C4	-1430	943
GTF3C5	-1789	1516
GTF3C6	2896	-3181
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HENMT1	-2871	-27
HEY2	-3510	2330
HIPK1	2327	-974
HIPK2	2508	-1520
HIVEP3	-842	2288
HSP90AA1	415	-781
HSPD1	-543	-2021
HUS1	-40	-522
ICE2	-2994	1344
IL2RA	-2353	-6462
ING2	1592	-2115
ING5	-3556	-763
INTS1	243	-1451
INTS10	1552	-1477
INTS12	84	1798
INTS2	-588	-5323
INTS3	2562	1491
INTS4	-3150	-2255
INTS5	-330	-2452
INTS6	2258	-1482
INTS7	-2650	-3259
INTS8	3674	-1509
INTS9	-2085	-2341
IPO8	1706	-2546
ITCH	429	-1366
ITGA4	-4108	1419
ITGA5	3362	-6767
ITGAL	-4114	2268
IWS1	2349	-60
JARID2	3149	-2338
JMY	-4347	-4364
JUN	1372	69
JUNB	2887	-3031
KAT2A	-3767	-5050
KAT2B	-704	-1588
KAT5	419	-650
KCTD1	-558	-6296
KCTD6	1605	886
KMT2A	-3933	2484
KMT2C	22	-6379
KMT2D	1065	-6199
KMT2E	-1909	2390
KRAS	1294	440
L3MBTL2	-3980	-4114
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAMTOR4	1631	-6150
LAMTOR5	3910	-5095
LBR	3693	-3506
LDB1	-3409	1270
LEO1	26	791
LMO2	3759	-5492
LRPPRC	-3636	-5728
LSM10	2631	-3871
LSM11	-3703	-4172
MAF	-3921	-4350
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAP2K6	4145	-1130
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPKAP1	1937	1057
MAX	1522	-3235
MBD2	2594	582
MBD3	-172	1673
MDC1	-4696	-902
MDM2	1471	-1318
MDM4	-377	-2440
MEAF6	-2755	-3609
MED1	-1217	-2271
MED10	-2937	-2572
MED13	824	590
MED15	-3549	2114
MED16	2032	1719
MED17	967	-1418
MED20	2864	-542
MED23	-2103	633
MED24	-2416	-2701
MED25	2547	-1286
MED26	1615	18
MED27	-3240	-960
MED30	-1688	491
MED31	456	445
MED4	1079	-4472
MED6	-284	560
MED7	55	778
MED8	3319	1289
MEN1	-2763	-2311
MGA	-3539	-3489
MLLT1	3488	-1901
MLLT3	-3400	1273
MLST8	98	287
MNAT1	-3019	311
MOV10	-4691	-6449
MSH2	-4317	83
MTA2	-2378	1649
MTA3	-3049	-1740
MTERF1	-1632	-5277
MTF2	-1303	501
MTOR	-3531	-1813
MYB	176	1502
MYBBP1A	-4376	-4510
MYBL1	-4784	883
NABP1	3622	-209
NABP2	-2385	-6524
NBN	710	750
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCOR1	2375	-3738
NCOR2	3521	-4281
NDC1	-4771	-5228
NDRG1	1714	149
NDUFA4	2716	288
NEDD4L	3534	-5066
NELFA	-1150	35
NELFB	121	1822
NELFCD	-1955	2444
NELFE	1359	1377
NFATC2	-4839	2414
NFE2	4398	-6723
NFIA	3680	-2592
NFIC	3821	-2759
NFIX	2018	-6361
NFYA	1190	1464
NFYB	-3535	-531
NFYC	3381	-3078
NOP2	-3314	-2438
NOTCH1	1739	1722
NOTCH4	-1578	-6455
NR1D1	-2922	1187
NR1D2	-3627	663
NR1H2	3254	-1471
NR1H3	-1011	-2305
NR1I2	-1260	-4903
NR2C1	-3442	-1463
NR2C2	-2948	119
NR2C2AP	-4284	-4688
NR3C1	190	-2420
NR3C2	-3730	324
NR4A1	-2135	657
NR4A2	-494	1416
NR4A3	-1560	954
NR6A1	3935	-5344
NRBP1	917	-1365
NUDT21	-1105	13
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
PABPN1	-170	-3743
PAF1	1195	-5838
PAPOLA	3102	775
PARP1	-4461	-5521
PBRM1	2194	2290
PCBP4	-4148	-1359
PCGF5	-1005	-3951
PCGF6	-224	-3963
PCNA	-1864	-511
PDPK1	2505	167
PHAX	-1618	694
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
PHF1	-4060	-1815
PHF19	-4724	-3270
PHF20	-566	904
PIDD1	-2068	-6641
PIN1	-972	-1656
PINK1	4169	-3597
PIP4K2A	-691	1772
PIP4K2B	-2536	-6347
PIP4K2C	-4341	-5573
PLAGL1	145	1666
PLD6	-1122	2227
PLK2	-832	-6257
PLK3	2816	1597
PMAIP1	-4153	-2202
PML	-3036	549
PMS2	-1709	1574
POLDIP3	3177	-5416
POLR1A	-3596	-755
POLR1B	-4105	-1952
POLR1C	-3778	-2688
POLR1D	2750	-2500
POLR1E	-4496	-4471
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POLR3A	-2377	2213
POLR3C	-2457	509
POLR3D	-4442	1264
POLR3E	-4160	-673
POLR3F	-1600	-5523
POLR3G	-1657	1201
POLR3GL	-2491	-6348
POLR3H	-3707	-510
POLR3K	-756	1383
POLRMT	-3799	-1636
POM121	-2762	-1787
POM121C	-2356	-4315
POU2F1	497	733
POU2F2	1502	950
PPARD	-1877	660
PPARGC1B	-1554	1840
PPM1A	3733	-3764
PPM1D	3473	-4316
PPP1R13B	-4370	1874
PPP1R13L	131	328
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5C	-4356	2376
PRDM1	-3050	799
PRDX1	3015	-877
PRDX2	1172	-5158
PRDX5	3911	-1661
PRKAA1	417	227
PRKAB1	405	-3297
PRKAB2	-2683	-1428
PRKACA	4377	-6032
PRKAG1	2166	-5980
PRKAG2	612	-5033
PRKCB	2983	-4518
PRKCQ	-4731	1372
PRKRA	-3175	-3442
PRMT1	-3038	-740
PRMT5	1213	-2112
PRR5	-4670	-1591
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTEN	3857	-1100
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN4	-4781	-3156
RABGGTA	-728	1696
RABGGTB	-1598	2306
RAD1	-4779	1965
RAD17	-3691	-1101
RAD50	-2424	2067
RAD51	-816	-696
RAD51D	-4255	-710
RAD9A	-4403	-403
RAD9B	1007	-6145
RAE1	1948	-39
RAN	-2179	1257
RANBP2	-259	-4704
RARA	2591	-5249
RARG	-1454	-5402
RB1	3934	-4740
RBBP4	-573	-3282
RBBP5	325	-779
RBBP8	-1410	-5854
RBL1	-3634	-3466
RBL2	-2338	-4497
RBM14	-2433	398
RBPJ	3993	-1118
RBX1	1413	-3241
RELA	-541	2085
RFC2	1890	-1206
RFC3	-3845	-803
RFC4	-3843	624
RFC5	-4565	-4946
RFFL	-521	-5968
RGCC	-2438	2408
RHEB	3346	-2334
RHNO1	-2040	-2816
RICTOR	-3355	1651
RING1	-1202	-1490
RMI2	-1205	1934
RNF111	2287	779
RNF2	1210	-1936
RNF34	-1908	42
RNGTT	976	-2952
RNMT	-4236	2172
RNPS1	-4416	-3160
RORA	-4632	2287
RPA1	-4680	-2495
RPA3	-3097	-1890
RPAP2	-3122	-3782
RPRD1A	1691	-3000
RPRD2	-1363	-2123
RPS27A	-2186	-2138
RPTOR	-3833	2134
RRAGA	2580	-1657
RRAGC	1887	-2585
RRAGD	4056	-6311
RRM2	-61	-574
RRM2B	2862	-5757
RRN3	-4373	-2882
RTF1	1224	-4613
RUNX1	3296	-4082
RUNX2	-4261	-5055
RUNX3	-4877	2402
RYBP	2169	1520
SAP130	-390	1164
SAP18	1922	-3579
SAP30	3651	-2185
SAP30BP	-2616	-1889
SAP30L	2008	-233
SATB2	2725	-6456
SCMH1	-1695	1397
SCO1	-3488	-1715
SCO2	-1280	-4657
SEC13	2286	-3749
SEH1L	-1833	-1615
SESN1	-3131	-3887
SESN2	1227	-3423
SESN3	-1062	1141
SETD1A	-1735	-2070
SETD1B	237	-5034
SETD9	-385	-6605
SFN	478	-5994
SGK1	1695	-6076
SIN3A	-3920	-4151
SIN3B	-1249	570
SIRT1	-1251	-1775
SIRT3	-3023	-1430
SKI	-4099	-2431
SKIL	-194	-3633
SKP1	1561	-2290
SKP2	-2780	-1566
SLBP	2074	-327
SLC2A3	4226	-4757
SLC38A9	920	-3360
SLU7	887	-3467
SMAD1	3832	-3272
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMAD6	3462	-3209
SMAD7	-4655	-4450
SMARCA2	-808	296
SMARCA4	1769	2317
SMARCA5	-693	673
SMARCB1	-1149	-714
SMARCC1	-3109	1327
SMARCC2	-1239	-3828
SMARCD1	-4492	-2643
SMARCD2	2939	967
SMARCE1	-1297	-3418
SMURF1	-771	1321
SMURF2	-3700	-3048
SMYD2	-3637	-3757
SNAPC1	211	343
SNAPC2	1910	-3914
SNAPC3	-2873	-4100
SNAPC4	-267	-6719
SNAPC5	-1137	1443
SNRPB	-721	-2182
SNRPD3	498	1486
SNRPE	196	-919
SNRPG	504	-4002
SNW1	2003	946
SOCS3	4414	2178
SOCS4	-1486	-1919
SOD2	1617	573
SP1	3746	-3141
SPI1	4090	-6766
SRC	-3100	-4427
SREBF1	2743	-4015
SRRM1	-1550	-2963
SRRT	-1551	-3758
SRSF11	-3620	-5151
SRSF2	-1769	2284
SRSF3	-698	-121
SRSF4	1305	-2328
SRSF7	-2857	2075
SRSF9	3262	-3686
SSB	-863	-1312
SSRP1	-4239	-2441
SSU72	1232	-4327
STAT1	-4575	2195
STK11	709	-5709
STUB1	-337	-2168
SUDS3	1670	-1851
SUMO1	2937	-3986
SUPT16H	-4379	-3702
SUPT4H1	966	-1899
SUPT5H	-2124	-3641
SUPT6H	-1997	285
SURF1	1217	-4976
SYMPK	-1926	-2815
TACO1	1620	-5534
TAF10	3073	1606
TAF11	-873	-719
TAF12	3604	-1765
TAF13	3147	-908
TAF15	-2044	-3109
TAF1A	-1699	-3366
TAF1B	-1741	913
TAF1C	-886	-1544
TAF1D	-2054	-5569
TAF2	-1849	-4149
TAF3	-546	-3002
TAF4	-518	-6161
TAF4B	-2590	-1647
TAF5	-1331	1150
TAF6	-2393	1804
TAF7	625	-3426
TAF8	1243	342
TAF9	390	1714
TARBP2	-967	-269
TBL1XR1	1687	962
TCEA1	-301	-4211
TCF12	-384	-4702
TCF3	-2132	-6049
TCF7	-3405	2023
TCF7L2	-1653	-3431
TDG	2829	621
TDRKH	-3387	-2886
TET1	-4076	1694
TET3	3517	2435
TFAM	-1532	-2635
TFAP2E	-1971	-6087
TFDP1	3847	-1587
TFDP2	-4878	-4793
TGFA	4154	-3020
TGFB1	1971	-6
TGIF1	-2942	-5815
TGIF2	-3529	-6609
THOC1	-3697	73
THOC5	3155	747
THOC7	2604	-369
THRA	-1980	-2798
TIGAR	2559	-1893
TMEM219	1341	-6062
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFRSF10D	4239	-5911
TNKS1BP1	-1659	-5457
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TOP3A	3499	-3594
TOPBP1	-1032	180
TP53	-4078	-739
TP53BP2	2173	-5830
TP53I3	4166	-6077
TP53INP1	2698	-2058
TP53RK	-4658	-2342
TPR	-2272	-973
TPX2	574	-4637
TRIAP1	72	-3808
TRIM28	-1482	1191
TRIM33	-3064	-2091
TSC1	-627	1527
TSC2	-257	895
TSN	-243	-3199
TSNAX	1534	-80
TTC5	-774	-1440
TTF1	-87	-4199
TWISTNB	-3220	-5099
TXN	3798	284
TXNIP	-3453	-2777
TXNRD1	3738	-4647
U2AF1	284	-5640
U2AF1L4	-1298	2171
U2AF2	1235	-306
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2I	-239	233
UBE2S	1785	2449
UBTF	-3389	1582
UHRF1	54	-396
USP7	2617	-2216
VDR	3712	-3651
VEGFA	3184	-2723
WDR33	-2475	-3224
WDR5	39	-5613
WDR61	28	-4752
WRN	-4674	-2102
WWOX	-4198	1732
WWP1	-3587	-1865
XPO5	-4027	-2879
YAF2	-2380	-3920
YEATS4	-1172	1953
YES1	-4790	-4415
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541
YY1	169	-5165
ZC3H8	-3638	-3807
ZFHX3	3232	-2025
ZFP1	-3907	-2240
ZFP14	-3631	1678
ZFP28	-2053	-6320
ZFP30	-4165	-366
ZFP37	-2723	-5928
ZFP90	-3403	824
ZFPM1	-3772	2378
ZIK1	-3912	2035
ZKSCAN1	694	-3843
ZKSCAN3	-2661	-5530
ZKSCAN4	-1583	-5770
ZKSCAN5	434	468
ZKSCAN8	-4216	-6728
ZNF10	-3834	-1897
ZNF101	-1720	2155
ZNF136	-4372	-3471
ZNF138	-4313	-5255
ZNF14	-4131	-4397
ZNF140	-2965	-2581
ZNF141	-2962	-526
ZNF143	3169	-418
ZNF155	-1519	-4127
ZNF160	-3165	-2923
ZNF169	-1862	-737
ZNF17	-3089	-1485
ZNF175	-2538	-5289
ZNF18	-758	-3535
ZNF180	-3963	-2110
ZNF184	-4192	-1046
ZNF189	1203	2001
ZNF19	-4170	907
ZNF2	-2476	-5367
ZNF20	1786	-4807
ZNF200	-55	-1750
ZNF202	-4126	1338
ZNF211	-4244	-6023
ZNF212	-3669	620
ZNF213	2401	-1128
ZNF215	-1151	-2720
ZNF221	-910	-6268
ZNF222	-24	-1983
ZNF223	-2119	-6465
ZNF224	-3564	-2768
ZNF226	-4044	-3429
ZNF227	-3395	-1334
ZNF23	-3824	-3592
ZNF233	-1195	-4234
ZNF234	-2816	-5598
ZNF235	-4279	-5194
ZNF248	-3871	-3321
ZNF25	-1661	-5487
ZNF250	-4613	554
ZNF253	-3828	-1053
ZNF257	-4014	-3813
ZNF26	-3624	-3960
ZNF264	-2454	-4068
ZNF268	-2207	-5808
ZNF274	-2742	-5798
ZNF282	1882	-5468
ZNF286A	-4478	-2915
ZNF287	-4733	-5090
ZNF3	-4753	-1141
ZNF302	-3817	659
ZNF311	-3622	-5855
ZNF324	-3334	-3484
ZNF324B	-4184	651
ZNF331	-2879	-2081
ZNF333	1412	-2425
ZNF337	-4391	-3809
ZNF33A	-2120	157
ZNF33B	-4558	-2030
ZNF34	-1698	-964
ZNF343	-4107	-4524
ZNF354A	1356	-4473
ZNF354C	-4069	-6378
ZNF382	-2280	-4717
ZNF394	411	-628
ZNF398	-1818	155
ZNF417	-1502	-2829
ZNF418	-2180	-6578
ZNF419	-4137	-5268
ZNF420	-3590	-3752
ZNF425	-2227	-4710
ZNF426	-1324	-3104
ZNF43	-4605	-5370
ZNF430	-1473	-4879
ZNF431	-3388	-5647
ZNF432	-4169	-5374
ZNF436	-3361	-5576
ZNF440	-3011	-5938
ZNF443	-1568	-4894
ZNF445	1126	-5606
ZNF446	-3726	-3030
ZNF461	-4647	-2540
ZNF468	-513	-4348
ZNF470	-3286	-6469
ZNF480	-1990	-4983
ZNF483	-3446	-5903
ZNF484	-3315	-304
ZNF490	-783	-2501
ZNF492	-1393	-6580
ZNF496	-4447	-3057
ZNF500	-4498	1026
ZNF506	-3256	-4344
ZNF517	-4363	-228
ZNF528	-4094	-6459
ZNF529	-3695	-3659
ZNF530	-4642	-6175
ZNF540	-3904	-4576
ZNF546	-1436	-1610
ZNF547	-1574	-4822
ZNF549	-4440	-5587
ZNF550	-4036	-5905
ZNF552	1731	-5023
ZNF554	-4534	-1275
ZNF559	-2885	-4261
ZNF561	-1293	-2945
ZNF563	-3812	-5992
ZNF564	-1352	-2468
ZNF566	-4275	-939
ZNF567	-2995	-5136
ZNF568	-4424	-6314
ZNF569	-4362	-352
ZNF570	-4449	-4872
ZNF571	-4516	-5324
ZNF573	-3242	-3023
ZNF582	-3192	-6112
ZNF583	-3431	-4848
ZNF584	-4271	-5742
ZNF585A	-2466	-4862
ZNF585B	-3890	-2710
ZNF587	-59	-1759
ZNF589	-1637	1425
ZNF596	-3558	-6669
ZNF597	-3297	-4633
ZNF600	-4299	-5453
ZNF605	-747	-1335
ZNF606	-3055	-5401
ZNF610	-1917	-6042
ZNF611	-1426	-5441
ZNF613	611	-5448
ZNF614	-3255	-2566
ZNF615	-1597	-5583
ZNF619	-3039	-6317
ZNF620	-4587	-5485
ZNF621	-4196	-3523
ZNF624	-988	-3879
ZNF627	-326	-2790
ZNF641	-2657	-5851
ZNF655	-1022	-2976
ZNF664	-3436	1571
ZNF665	-2685	-6565
ZNF668	1280	1462
ZNF670	-875	-5736
ZNF671	-2463	-680
ZNF677	-3095	-6476
ZNF678	-4128	530
ZNF681	-2855	-3353
ZNF684	-3449	-2033
ZNF688	-2649	-4023
ZNF689	-3441	-4943
ZNF691	-1949	-4147
ZNF692	-1263	-1190
ZNF696	-4484	-3058
ZNF70	-4592	-5340
ZNF700	-1440	-3707
ZNF701	-1066	-6116
ZNF703	-4175	-4320
ZNF706	-1898	-5848
ZNF707	-4438	-4401
ZNF708	-3383	-2881
ZNF709	-2918	-6445
ZNF710	2910	-6541
ZNF713	-1737	-3012
ZNF714	-987	-2480
ZNF717	-2959	-5768
ZNF736	-4428	-4463
ZNF737	-3430	-6022
ZNF74	-4652	-2918
ZNF740	-4237	878
ZNF746	3354	-3816
ZNF747	1378	-451
ZNF749	-3645	-5865
ZNF75A	-2479	-1824
ZNF761	-1712	-3885
ZNF764	-2086	-913
ZNF77	-4172	-489
ZNF771	-2367	-3926
ZNF772	-736	-5966
ZNF774	1748	-1078
ZNF775	1932	-4991
ZNF776	112	-3870
ZNF777	-2261	-4823
ZNF778	-3841	1050
ZNF782	-3133	128
ZNF785	-2212	-5042
ZNF786	-2209	56
ZNF79	-3042	470
ZNF790	-3830	-6139
ZNF791	-2511	-5116
ZNF792	-3010	645
ZNF793	-3296	-6557
ZNF799	-3658	-6025
ZNF839	-668	-6246
ZNF92	-3748	-2695
ZNRD1	-1621	-2166
ZSCAN25	-3303	2482

---

---

Hemostasis

Hemostasis

metric	value
setSize	304
pMANOVA	1.94e-10
p.adjustMANOVA	1.28e-08
s.dist	0.224
s.RNA	0.224
s.meth	0.0014
p.RNA	2.71e-11
p.meth	0.967

Top 20 genes

Gene	RNA	meth
ACTN1	4259	2335
DGKG	3467	2259
GNG5	4068	1920
WDR1	2980	2364
S100A10	2825	2282
PPP2CB	3404	1797
MAPK1	3257	1865
TNFRSF10B	3810	1433
ITGB2	4091	1322
ATP2A2	3601	1489
RHOA	3688	1313
PTPN1	2276	2074
CALU	3485	1252
RAD51B	2056	1987
RAC1	3977	971
STIM1	1396	2500
GNAS	3567	951
CFL1	3703	912
RHOG	3876	860
SDC4	2765	1193

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2185	-3533
AAMP	-1094	-5298
ABCC4	3277	-3153
ABHD12	-3885	-129
ABHD6	-644	-284
ABL1	69	-4891
ACTN1	4259	2335
ACTN4	1939	-2928
AK3	53	-5656
AKAP1	-4228	-1116
AKAP10	3183	-6099
AKT1	1248	-1942
ALDOA	4289	-1349
ANXA5	3631	-2845
APBB1IP	4055	-5120
APLP2	4302	-3465
APP	4212	-5300
ARRB1	659	-6363
ARRB2	3858	-2243
ATP1B1	-3115	111
ATP1B3	-283	1223
ATP2A1	-1323	-4587
ATP2A2	3601	1489
ATP2A3	-315	1190
ATP2B4	-1545	1124
BRPF3	-2021	-937
BSG	4260	-1562
C1QBP	-287	-2507
CABLES2	-2746	939
CALM1	-614	-5019
CALU	3485	1252
CAP1	3678	-553
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CAV1	584	-2432
CD2	-4542	2510
CD244	-3270	-3183
CD44	3745	266
CD47	-4770	-114
CD48	473	2043
CD58	2760	-3228
CD63	4327	-1017
CD74	-4409	-4283
CD84	1176	-6400
CDC37L1	-2833	1097
CDC42	3265	-2719
CDK2	-1524	1018
CDK5	3942	-506
CEACAM1	2970	-5827
CENPE	232	-4165
CFL1	3703	912
CHID1	904	-254
CRK	4109	-4581
CSK	2014	862
CYB5R1	4410	-1352
DAGLB	2332	-6635
DGKA	-2494	2375
DGKD	-165	546
DGKE	-4343	-953
DGKG	3467	2259
DGKH	-950	-6190
DGKQ	-2756	1446
DGKZ	-1727	-6294
DOCK10	-3862	-5645
DOCK4	3390	697
DOCK7	-717	-5883
DOCK8	2431	-944
DOCK9	-3734	1757
DOK2	-270	-2493
EHD1	1598	-1110
EHD2	2456	-6731
EHD3	1875	-4198
ENDOD1	1143	-4107
F11R	3640	-5665
F12	4416	-1719
FAM3C	-3567	527
FERMT3	4298	-1343
FGR	3790	-5292
FYN	-4569	1957
GATA3	-4787	1861
GLG1	-88	-3693
GNA12	1135	-3386
GNA13	2328	-2285
GNA15	4401	-6690
GNAI2	3614	-1747
GNAI3	3575	-909
GNAQ	4150	-6733
GNAS	3567	951
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GRB2	4321	-2295
GTPBP2	2596	-487
GYPC	3001	-6224
HABP4	-4095	230
HDAC1	124	-1016
HDAC2	2158	-46
HMG20B	1822	-3649
HRAS	-989	-4780
INPP5D	-1183	-3735
IRF1	-2898	1887
IRF2	2676	-2044
ITGA1	4037	-4187
ITGA2	1463	-3856
ITGA4	-4108	1419
ITGA5	3362	-6767
ITGA6	-1420	600
ITGAL	-4114	2268
ITGAV	2458	-5201
ITGB2	4091	1322
ITPK1	2823	-2385
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JAK2	834	-1751
JAM2	80	-2837
JMJD1C	1061	-2964
KCNMB4	2790	-6092
KDM1A	-3304	900
KIF11	306	-4751
KIF13B	2412	-3303
KIF15	-963	-563
KIF16B	905	-6359
KIF18A	-818	-2125
KIF18B	-35	-3342
KIF1B	3730	-4142
KIF20A	1956	-231
KIF20B	-2609	-649
KIF21A	-4610	-1704
KIF21B	-2139	1128
KIF22	-4864	-1801
KIF23	2168	-3340
KIF26B	-4519	-6613
KIF27	826	-1527
KIF2A	-332	1788
KIF2C	262	-1625
KIF3A	-4676	-2118
KIF3B	1297	-2584
KIF3C	3823	-5135
KIF5B	3643	-3520
KIF6	367	-5646
KIF9	1537	-2489
KIFAP3	-2987	1836
KIFC1	-53	901
KIFC2	-477	-5893
KLC1	2174	-1283
KLC2	-2966	-5681
KLC4	-2743	-4132
KRAS	1294	440
LCK	-4404	2489
LCP2	-357	1588
LRP8	1683	-214
MAFF	135	-3863
MAFG	4386	-6073
MAFK	292	-2942
MANF	813	1947
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MFN1	-1517	-659
MFN2	2812	-4801
MICAL1	2450	-4934
MIF	-1139	-2943
MYB	176	1502
NFE2	4398	-6723
NHLRC2	-2578	-716
NOS3	-515	-1770
OLA1	1868	-508
ORAI1	-2313	-4764
ORAI2	2440	-4356
P2RX1	3818	-6722
P2RX4	3391	174
P2RX5	-122	393
P2RX6	-1456	-3907
P2RY1	3509	-5377
PAFAH2	-4858	-1539
PCYOX1L	-587	339
PDE1B	2288	-6326
PDE2A	-232	-391
PDE5A	2820	-5047
PDE9A	-1910	-5405
PDPK1	2505	167
PFN1	2155	833
PHACTR2	2128	-6672
PHF21A	4296	-3398
PICK1	1276	-3746
PIK3CA	1725	-1445
PIK3CG	646	-2045
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R5	-695	514
PLAU	1855	-6512
PLAUR	3843	-6237
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLEK	667	-5891
PPIA	-2188	490
PPIL2	-3557	360
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5A	2378	381
PPP2R5B	2877	-6343
PPP2R5C	-4356	2376
PPP2R5D	777	-4349
PPP2R5E	-200	-2288
PRCP	3691	368
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PRKCA	368	810
PRKCB	2983	-4518
PRKCD	4146	584
PRKCE	-2656	-5632
PRKCH	-4848	1376
PRKCQ	-4731	1372
PRKCZ	-4414	-5220
PRTN3	2850	-6448
PSAP	2899	-4192
PTK2	1637	920
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN6	2483	-4586
QSOX1	4308	-1087
RAB5A	3055	-1686
RAC1	3977	971
RAC2	1994	-868
RACGAP1	937	1472
RAD51B	2056	1987
RAF1	3548	-314
RAP1A	3142	323
RAP1B	1106	-1031
RASGRP1	-4601	2119
RASGRP2	-2706	1508
RBSN	-1371	-2813
RCOR1	4193	-4864
RHOA	3688	1313
RHOB	378	-4992
RHOG	3876	860
S100A10	2825	2282
SCCPDH	3498	-5477
SDC4	2765	1193
SELPLG	1574	-1609
SERPINB6	2273	-5578
SERPINB8	4246	-6095
SERPINE2	2674	-6537
SH2B1	-2800	-1068
SH2B3	1357	1699
SHC1	1469	-2954
SIN3A	-3920	-4151
SLC16A1	1645	576
SLC16A3	4075	-6120
SLC3A2	1969	-1667
SLC7A11	-1733	-6233
SLC7A5	1054	-6143
SLC7A6	-1921	-2873
SLC8A3	572	-5398
SOD1	-1490	-1019
SOS1	-1758	-6775
SPN	-4883	-3994
SRC	-3100	-4427
SRGN	4017	-2722
SRI	2759	-1804
STIM1	1396	2500
STX4	200	-6001
STXBP2	4178	-6352
STXBP3	3213	-1306
SYK	4194	-5054
TAGLN2	3219	-1136
TEX264	-2862	55
TGFB1	1971	-6
TGFB2	-2458	-6761
TGFB3	-2516	-5946
TLN1	3884	191
TMX3	-255	-6313
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFRSF10D	4239	-5911
TOR4A	4106	-6704
TP53	-4078	-739
TUBA4A	2717	-4571
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCL	3178	-5870
VEGFA	3184	-2723
VPS45	809	-3464
VTI1B	4081	-359
WDR1	2980	2364
WEE1	-3232	1982
YES1	-4790	-4415
YWHAZ	2220	541
ZFPM1	-3772	2378

---

---

Diseases of signal transduction by growth factor receptors and second messengers

Diseases of signal transduction by growth factor receptors and second messengers

metric	value
setSize	260
pMANOVA	2.05e-10
p.adjustMANOVA	1.28e-08
s.dist	0.24
s.RNA	0.24
s.meth	0.0129
p.RNA	3.64e-11
p.meth	0.723

Top 20 genes

Gene	RNA	meth
QKI	4113	2193
PPP2CB	3404	1797
MAPK1	3257	1865
BCL2L11	3144	1781
YWHAB	2609	2125
PPP1CB	3008	1839
PAPSS1	4158	1297
PSMA7	3060	1752
PIK3CD	2436	2189
APH1B	2525	2056
PSMD1	3121	1660
CBL	3300	1456
CHUK	3527	1343
IQGAP1	3672	1271
PSME3	3757	1116
ADAM10	3964	976
RAC1	3977	971
KSR1	1447	2466
PSMD12	2688	1314
PSMB2	1441	2355

Click HERE to show all gene set members

All member genes

	RNA	meth
ADAM10	3964	976
ADAM17	3540	774
AGGF1	2543	-3806
AGK	-4734	-3004
AGTRAP	4129	-6548
AKAP9	-1540	-3186
AKT1	1248	-1942
AKT1S1	3491	-2319
AKT2	108	-141
AP3B1	3779	-3148
APBB1IP	4055	-5120
APC	1087	-4775
APH1A	1483	-6066
APH1B	2525	2056
ARRB1	659	-6363
ARRB2	3858	-2243
ATG7	3598	569
AXIN1	-3733	-5655
BAD	2952	-1382
BAG4	3782	-3089
BCL2L11	3144	1781
BCR	-2308	-6682
BIN2	2275	-2805
BRAF	406	-4347
BRAP	2050	-3662
CALM1	-614	-5019
CAMK2D	-4549	-2867
CAMK2G	598	2354
CASP9	3414	-234
CBL	3300	1456
CCNC	596	-1138
CDK8	-597	-5509
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CHUK	3527	1343
CLCN6	725	-775
CNTRL	-2141	-6676
CPSF6	-1835	2374
CREB1	-423	-672
CREBBP	1169	-5804
CSK	2014	862
CSNK1A1	3434	769
CTBP1	-2048	2394
CTNNB1	2647	-1691
CUL1	-4385	-5146
CUX1	4088	-2129
DERL2	1003	-2287
DUSP10	-486	-1469
DUSP16	-2084	-2622
DUSP6	1572	-6763
DUSP7	-965	-1322
EP300	2504	-4509
ERBB2	-4860	-5145
ERLEC1	246	-2711
ERLIN2	4085	-4042
ESR2	-3196	-2661
ETV6	1983	-6394
FBXW7	-2109	-5428
FGF9	-3030	1634
FGFR1OP	-2152	985
FGFR1OP2	3503	-2734
FIP1L1	-2679	-2274
FKBP1A	4177	-4465
FOXO1	-3171	-5036
FOXO3	3983	711
FRS2	-1016	-1999
FXR1	2066	-1166
FYN	-4569	1957
FZD5	4425	-2513
FZD6	-1991	-6235
FZD8	-2326	-6560
GAB2	3616	-6153
GOLGA4	-1210	-155
GRB2	4321	-2295
GSK3A	3432	-2192
GSK3B	2793	736
GTF2F1	1892	-1723
GTF2F2	2127	-2885
HBEGF	1808	-6428
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HEY2	-3510	2330
HHAT	-3114	-5389
HRAS	-989	-4780
HSP90AA1	415	-781
IQGAP1	3672	1271
IRS1	563	-4060
IRS2	3752	-5410
JAK2	834	-1751
KANK1	-1164	-270
KAT2A	-3767	-5050
KAT2B	-704	-1588
KRAS	1294	440
KSR1	1447	2466
LCK	-4404	2489
LMNA	1334	-6474
LRP5	1500	1949
LRP6	252	-4544
LRRFIP1	2455	-1040
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP3K11	3368	-2732
MAPK1	3257	1865
MAPK3	4187	-2448
MAPKAP1	1937	1057
MARK3	4010	-3461
MDM2	1471	-1318
MIB1	-895	-2718
MLST8	98	287
MPRIP	-3919	755
MTOR	-3531	-1813
MYO18A	-1170	-6701
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCOR1	2375	-3738
NCOR2	3521	-4281
NCSTN	4222	-3821
NF1	1012	-2145
NOTCH1	1739	1722
NR4A1	-2135	657
OS9	4053	-975
PAPSS1	4158	1297
PDPK1	2505	167
PEBP1	-4273	-152
PHB	-914	-3178
PIK3AP1	3450	-4753
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PLCG1	-3823	-3541
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
PPP1CB	3008	1839
PPP1CC	2576	-754
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5A	2378	381
PPP2R5B	2877	-6343
PPP2R5C	-4356	2376
PPP2R5D	777	-4349
PPP2R5E	-200	-2288
PRR5	-4670	-1591
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTEN	3857	-1100
PTPN11	2065	-2302
PTPN12	3633	-1077
QKI	4113	2193
RAC1	3977	971
RAC2	1994	-868
RAF1	3548	-314
RAP1A	3142	323
RAP1B	1106	-1031
RBPJ	3993	-1118
RBX1	1413	-3241
RHOG	3876	860
RICTOR	-3355	1651
RPS27A	-2186	-2138
RPS6KB2	209	1145
SEL1L	2854	-2307
SHC1	1469	-2954
SHOC2	3168	-3532
SKP1	1561	-2290
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SND1	1354	-1905
SNW1	2003	946
SOS1	-1758	-6775
SPRED1	-2940	-6227
SPRED2	2902	521
SPRED3	-2225	-4087
SRC	-3100	-4427
STAT1	-4575	2195
STAT3	3649	-3606
STAT5A	2944	-6427
STAT5B	2958	-3446
STRN	1292	1051
SYVN1	322	-5153
TBL1XR1	1687	962
TCF7L2	-1653	-3431
TGFA	4154	-3020
TGFB1	1971	-6
TGFBR1	507	-6163
TGFBR2	1344	-5224
TLN1	3884	191
TNKS	-3013	-1583
TNKS2	-164	-449
TRIM24	1316	-5752
TSC2	-257	895
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
VAV1	3569	-3184
VCL	3178	-5870
VCP	2927	-2411
WDR48	-4493	-5481
YES1	-4790	-4415
YWHAB	2609	2125
ZC3HAV1	-3677	1635
ZFYVE9	-2531	-4766
ZMYM2	1138	-896

---

---

Generic Transcription Pathway

Generic Transcription Pathway

metric	value
setSize	803
pMANOVA	4.39e-10
p.adjustMANOVA	2.59e-08
s.dist	0.136
s.RNA	-0.129
s.meth	-0.0423
p.RNA	1.28e-09
p.meth	0.0473

Top 20 genes

Gene	RNA	meth
MOV10	-4691	-6449
ZNF530	-4642	-6175
ZKSCAN8	-4216	-6728
ZNF568	-4424	-6314
AUTS2	-4756	-5652
ZNF528	-4094	-6459
ZNF354C	-4069	-6378
CCND2	-4504	-5700
ZNF211	-4244	-6023
ZNF620	-4587	-5485
ERBB2	-4860	-5145
ZNF549	-4440	-5587
ZNF43	-4605	-5370
CNOT6L	-4344	-5686
PARP1	-4461	-5521
ZNF584	-4271	-5742
ZNF70	-4592	-5340
PIP4K2C	-4341	-5573
ZNF287	-4733	-5090
ZNF571	-4516	-5324

Click HERE to show all gene set members

All member genes

	RNA	meth
ABL1	69	-4891
ACTL6A	-2395	-4851
AGO1	2205	1997
AGO2	983	2447
AGO3	-318	-6442
AKT1	1248	-1942
AKT2	108	-141
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC15	4157	-1379
ANAPC16	-645	-4507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
APAF1	4182	-2104
ARID1A	1819	-6716
ARID1B	-1691	1093
ARID2	-1177	-657
ARID3A	3916	-4723
ASH2L	2381	-3791
ATAD2	-4041	-1835
ATM	-4028	202
ATR	-3783	970
ATRIP	-4340	-2737
ATXN3	502	1703
AURKA	1188	-385
AURKB	309	-889
AUTS2	-4756	-5652
AXIN1	-3733	-5655
BANP	208	-4163
BARD1	-1018	-2910
BAX	2386	-3623
BBC3	-2642	-3845
BCL2L11	3144	1781
BCL6	4305	-299
BID	2427	844
BIRC5	1432	-84
BLM	-1434	-2909
BMI1	-3450	-6383
BNIP3L	4325	-851
BRCA1	2537	-4609
BRD1	-4083	2465
BRD2	-3312	1256
BRD7	-12	-5008
BRIP1	-4545	-2323
BRPF1	-2320	89
BRPF3	-2021	-937
BTG1	-1579	2084
BTG2	922	-1900
CALM1	-614	-5019
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAMK4	-3176	1482
CASP1	1434	-1448
CASP10	-1033	-6612
CASP6	-862	-4898
CAT	4221	-3922
CAV1	584	-2432
CBFB	680	-3766
CBX3	1810	-859
CBX4	706	-5288
CBX6	1438	-3511
CBX8	2136	2207
CCNA2	521	-1132
CCNB1	144	1492
CCNC	596	-1138
CCND1	-2169	-6213
CCND2	-4504	-5700
CCND3	3252	905
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCNG1	1839	131
CCNG2	2810	-3720
CCNH	249	-3754
CCNK	942	-6142
CCNT1	-3342	1773
CDC16	-1863	-4152
CDC23	-4319	-707
CDC25C	1885	-2877
CDC7	-2607	-202
CDK1	454	-4215
CDK12	-417	-805
CDK13	-2893	-700
CDK2	-1524	1018
CDK4	-4195	-1295
CDK5	3942	-506
CDK5R1	-356	-2113
CDK6	-1983	-2864
CDK7	2020	275
CDK8	-597	-5509
CDK9	-1184	1524
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDKN2A	-1623	-4511
CEBPB	3621	-5089
CENPJ	-4301	-838
CHD3	-3299	422
CHD4	-1372	-4634
CHEK1	-752	-211
CHEK2	-1306	-2709
CITED2	2650	-104
CITED4	3297	-701
CNOT1	-1283	-4543
CNOT10	-800	-361
CNOT11	661	-2236
CNOT3	2060	565
CNOT4	-392	-3064
CNOT6	1776	-3728
CNOT6L	-4344	-5686
CNOT7	-1157	349
CNOT8	3743	-2054
COX11	-4162	-789
COX14	-463	-3835
COX16	66	-1160
COX19	-2202	-4047
COX20	-1528	-4841
COX4I1	1505	-5506
COX5A	2520	-2944
COX5B	2572	382
COX6A1	1958	-961
COX6B1	2260	-2634
COX6C	228	-1411
COX7A2L	3430	-2476
COX7C	178	-4071
COX8A	2789	-1258
CRADD	2031	-4017
CREB1	-423	-672
CREBBP	1169	-5804
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CTDP1	2551	1112
CTLA4	-3873	2506
CTNNB1	2647	-1691
CTSL	1667	-6671
CTSV	-848	-5834
CUL1	-4385	-5146
CYCS	-386	-3927
DAXX	-3887	-450
DDB2	-4468	-561
DDIT3	1835	-3177
DDIT4	-502	-2588
DEK	854	1060
DGCR8	-4603	-495
DNA2	-871	-2087
DPY30	1310	-1010
DYRK2	-4396	-3036
E2F1	2654	-1005
E2F4	2607	-172
E2F5	-2781	-2646
E2F6	-1495	-2466
E2F7	-1816	-1622
E2F8	926	-4363
EED	-3277	-1174
EHMT1	-2969	-1697
EHMT2	-2882	-1059
ELF1	515	-1733
ELF2	847	-3373
ELL	1902	574
EP300	2504	-4509
EPC1	-3604	-2797
ERBB2	-4860	-5145
ERCC2	1202	-594
ERCC3	-2537	969
ESR2	-3196	-2661
ESRRA	2370	-2927
EXO1	-481	-3123
EZH2	-3517	-20
FANCC	-4387	-3902
FANCD2	-4393	1778
FANCI	-4672	-4622
FAS	1270	-5824
FBXO32	-4006	-1875
FBXW7	-2109	-5428
FKBP5	4105	-5653
FOS	2486	2149
FOXO1	-3171	-5036
FOXO3	3983	711
FZR1	-666	-758
GADD45A	4281	-2249
GATA3	-4787	1861
GATAD2A	1016	-256
GATAD2B	-535	-2871
GLS	-4521	-4781
GPAM	-3559	-4630
GPI	2523	-2211
GPS2	-290	-857
GSK3B	2793	736
GSR	4279	-4724
GTF2F1	1892	-1723
GTF2F2	2127	-2885
GTF2H3	-664	1025
GTF2H4	-874	-2761
GTF2H5	1343	691
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HEY2	-3510	2330
HIPK1	2327	-974
HIPK2	2508	-1520
HIVEP3	-842	2288
HSPD1	-543	-2021
HUS1	-40	-522
IL2RA	-2353	-6462
ING2	1592	-2115
ING5	-3556	-763
ITCH	429	-1366
ITGA4	-4108	1419
ITGA5	3362	-6767
ITGAL	-4114	2268
JMY	-4347	-4364
JUN	1372	69
JUNB	2887	-3031
KAT2A	-3767	-5050
KAT2B	-704	-1588
KAT5	419	-650
KCTD1	-558	-6296
KCTD6	1605	886
KMT2A	-3933	2484
KMT2C	22	-6379
KMT2D	1065	-6199
KMT2E	-1909	2390
KRAS	1294	440
L3MBTL2	-3980	-4114
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAMTOR4	1631	-6150
LAMTOR5	3910	-5095
LBR	3693	-3506
LDB1	-3409	1270
LMO2	3759	-5492
LRPPRC	-3636	-5728
MAF	-3921	-4350
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAP2K6	4145	-1130
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPKAP1	1937	1057
MAX	1522	-3235
MBD3	-172	1673
MDC1	-4696	-902
MDM2	1471	-1318
MDM4	-377	-2440
MEAF6	-2755	-3609
MED1	-1217	-2271
MED10	-2937	-2572
MED13	824	590
MED15	-3549	2114
MED16	2032	1719
MED17	967	-1418
MED20	2864	-542
MED23	-2103	633
MED24	-2416	-2701
MED25	2547	-1286
MED26	1615	18
MED27	-3240	-960
MED30	-1688	491
MED31	456	445
MED4	1079	-4472
MED6	-284	560
MED7	55	778
MED8	3319	1289
MEN1	-2763	-2311
MGA	-3539	-3489
MLST8	98	287
MNAT1	-3019	311
MOV10	-4691	-6449
MSH2	-4317	83
MTA2	-2378	1649
MTOR	-3531	-1813
MYB	176	1502
NBN	710	750
NCOR1	2375	-3738
NCOR2	3521	-4281
NDRG1	1714	149
NDUFA4	2716	288
NEDD4L	3534	-5066
NELFA	-1150	35
NELFB	121	1822
NELFCD	-1955	2444
NELFE	1359	1377
NFATC2	-4839	2414
NFE2	4398	-6723
NFYA	1190	1464
NFYB	-3535	-531
NFYC	3381	-3078
NOP2	-3314	-2438
NOTCH1	1739	1722
NOTCH4	-1578	-6455
NR1D1	-2922	1187
NR1D2	-3627	663
NR1H2	3254	-1471
NR1H3	-1011	-2305
NR1I2	-1260	-4903
NR2C1	-3442	-1463
NR2C2	-2948	119
NR2C2AP	-4284	-4688
NR3C1	190	-2420
NR3C2	-3730	324
NR4A1	-2135	657
NR4A2	-494	1416
NR4A3	-1560	954
NR6A1	3935	-5344
NRBP1	917	-1365
PARP1	-4461	-5521
PBRM1	2194	2290
PCBP4	-4148	-1359
PCGF5	-1005	-3951
PCGF6	-224	-3963
PCNA	-1864	-511
PDPK1	2505	167
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
PHF20	-566	904
PIDD1	-2068	-6641
PIN1	-972	-1656
PINK1	4169	-3597
PIP4K2A	-691	1772
PIP4K2B	-2536	-6347
PIP4K2C	-4341	-5573
PLAGL1	145	1666
PLK2	-832	-6257
PLK3	2816	1597
PMAIP1	-4153	-2202
PML	-3036	549
PMS2	-1709	1574
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
PPARD	-1877	660
PPARGC1B	-1554	1840
PPM1A	3733	-3764
PPM1D	3473	-4316
PPP1R13B	-4370	1874
PPP1R13L	131	328
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5C	-4356	2376
PRDM1	-3050	799
PRDX1	3015	-877
PRDX2	1172	-5158
PRDX5	3911	-1661
PRKAA1	417	227
PRKAB1	405	-3297
PRKAB2	-2683	-1428
PRKACA	4377	-6032
PRKAG1	2166	-5980
PRKAG2	612	-5033
PRKCB	2983	-4518
PRKCQ	-4731	1372
PRMT1	-3038	-740
PRMT5	1213	-2112
PRR5	-4670	-1591
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTEN	3857	-1100
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN4	-4781	-3156
RABGGTA	-728	1696
RABGGTB	-1598	2306
RAD1	-4779	1965
RAD17	-3691	-1101
RAD50	-2424	2067
RAD51	-816	-696
RAD51D	-4255	-710
RAD9A	-4403	-403
RAD9B	1007	-6145
RARA	2591	-5249
RARG	-1454	-5402
RB1	3934	-4740
RBBP4	-573	-3282
RBBP5	325	-779
RBBP8	-1410	-5854
RBL1	-3634	-3466
RBL2	-2338	-4497
RBM14	-2433	398
RBPJ	3993	-1118
RBX1	1413	-3241
RELA	-541	2085
RFC2	1890	-1206
RFC3	-3845	-803
RFC4	-3843	624
RFC5	-4565	-4946
RFFL	-521	-5968
RGCC	-2438	2408
RHEB	3346	-2334
RHNO1	-2040	-2816
RICTOR	-3355	1651
RING1	-1202	-1490
RMI2	-1205	1934
RNF111	2287	779
RNF2	1210	-1936
RNF34	-1908	42
RORA	-4632	2287
RPA1	-4680	-2495
RPA3	-3097	-1890
RPS27A	-2186	-2138
RPTOR	-3833	2134
RRAGA	2580	-1657
RRAGC	1887	-2585
RRAGD	4056	-6311
RRM2	-61	-574
RRM2B	2862	-5757
RUNX1	3296	-4082
RUNX2	-4261	-5055
RUNX3	-4877	2402
RYBP	2169	1520
SATB2	2725	-6456
SCMH1	-1695	1397
SCO1	-3488	-1715
SCO2	-1280	-4657
SESN1	-3131	-3887
SESN2	1227	-3423
SESN3	-1062	1141
SETD1A	-1735	-2070
SETD1B	237	-5034
SETD9	-385	-6605
SFN	478	-5994
SGK1	1695	-6076
SIN3A	-3920	-4151
SIN3B	-1249	570
SIRT1	-1251	-1775
SIRT3	-3023	-1430
SKI	-4099	-2431
SKIL	-194	-3633
SKP1	1561	-2290
SKP2	-2780	-1566
SLC2A3	4226	-4757
SLC38A9	920	-3360
SMAD1	3832	-3272
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMAD6	3462	-3209
SMAD7	-4655	-4450
SMARCA2	-808	296
SMARCA4	1769	2317
SMARCB1	-1149	-714
SMARCC1	-3109	1327
SMARCC2	-1239	-3828
SMARCD1	-4492	-2643
SMARCD2	2939	967
SMARCE1	-1297	-3418
SMURF1	-771	1321
SMURF2	-3700	-3048
SMYD2	-3637	-3757
SNW1	2003	946
SOCS3	4414	2178
SOCS4	-1486	-1919
SOD2	1617	573
SP1	3746	-3141
SPI1	4090	-6766
SRC	-3100	-4427
SREBF1	2743	-4015
SSRP1	-4239	-2441
STAT1	-4575	2195
STK11	709	-5709
STUB1	-337	-2168
SUMO1	2937	-3986
SUPT16H	-4379	-3702
SUPT4H1	966	-1899
SUPT5H	-2124	-3641
SURF1	1217	-4976
TACO1	1620	-5534
TAF10	3073	1606
TAF11	-873	-719
TAF12	3604	-1765
TAF13	3147	-908
TAF15	-2044	-3109
TAF2	-1849	-4149
TAF3	-546	-3002
TAF4	-518	-6161
TAF4B	-2590	-1647
TAF5	-1331	1150
TAF6	-2393	1804
TAF7	625	-3426
TAF9	390	1714
TBL1XR1	1687	962
TCEA1	-301	-4211
TCF12	-384	-4702
TCF3	-2132	-6049
TCF7	-3405	2023
TCF7L2	-1653	-3431
TFAP2E	-1971	-6087
TFDP1	3847	-1587
TFDP2	-4878	-4793
TGFA	4154	-3020
TGFB1	1971	-6
TGIF1	-2942	-5815
TGIF2	-3529	-6609
THRA	-1980	-2798
TIGAR	2559	-1893
TMEM219	1341	-6062
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFRSF10D	4239	-5911
TNKS1BP1	-1659	-5457
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TOP3A	3499	-3594
TOPBP1	-1032	180
TP53	-4078	-739
TP53BP2	2173	-5830
TP53I3	4166	-6077
TP53INP1	2698	-2058
TP53RK	-4658	-2342
TPX2	574	-4637
TRIAP1	72	-3808
TRIM28	-1482	1191
TRIM33	-3064	-2091
TSC1	-627	1527
TSC2	-257	895
TTC5	-774	-1440
TXN	3798	284
TXNIP	-3453	-2777
TXNRD1	3738	-4647
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2I	-239	233
UBE2S	1785	2449
USP7	2617	-2216
VDR	3712	-3651
VEGFA	3184	-2723
WDR5	39	-5613
WRN	-4674	-2102
WWOX	-4198	1732
WWP1	-3587	-1865
YAF2	-2380	-3920
YEATS4	-1172	1953
YES1	-4790	-4415
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541
YY1	169	-5165
ZFHX3	3232	-2025
ZFP1	-3907	-2240
ZFP14	-3631	1678
ZFP28	-2053	-6320
ZFP30	-4165	-366
ZFP37	-2723	-5928
ZFP90	-3403	824
ZFPM1	-3772	2378
ZIK1	-3912	2035
ZKSCAN1	694	-3843
ZKSCAN3	-2661	-5530
ZKSCAN4	-1583	-5770
ZKSCAN5	434	468
ZKSCAN8	-4216	-6728
ZNF10	-3834	-1897
ZNF101	-1720	2155
ZNF136	-4372	-3471
ZNF138	-4313	-5255
ZNF14	-4131	-4397
ZNF140	-2965	-2581
ZNF141	-2962	-526
ZNF155	-1519	-4127
ZNF160	-3165	-2923
ZNF169	-1862	-737
ZNF17	-3089	-1485
ZNF175	-2538	-5289
ZNF18	-758	-3535
ZNF180	-3963	-2110
ZNF184	-4192	-1046
ZNF189	1203	2001
ZNF19	-4170	907
ZNF2	-2476	-5367
ZNF20	1786	-4807
ZNF200	-55	-1750
ZNF202	-4126	1338
ZNF211	-4244	-6023
ZNF212	-3669	620
ZNF213	2401	-1128
ZNF215	-1151	-2720
ZNF221	-910	-6268
ZNF222	-24	-1983
ZNF223	-2119	-6465
ZNF224	-3564	-2768
ZNF226	-4044	-3429
ZNF227	-3395	-1334
ZNF23	-3824	-3592
ZNF233	-1195	-4234
ZNF234	-2816	-5598
ZNF235	-4279	-5194
ZNF248	-3871	-3321
ZNF25	-1661	-5487
ZNF250	-4613	554
ZNF253	-3828	-1053
ZNF257	-4014	-3813
ZNF26	-3624	-3960
ZNF264	-2454	-4068
ZNF268	-2207	-5808
ZNF274	-2742	-5798
ZNF282	1882	-5468
ZNF286A	-4478	-2915
ZNF287	-4733	-5090
ZNF3	-4753	-1141
ZNF302	-3817	659
ZNF311	-3622	-5855
ZNF324	-3334	-3484
ZNF324B	-4184	651
ZNF331	-2879	-2081
ZNF333	1412	-2425
ZNF337	-4391	-3809
ZNF33A	-2120	157
ZNF33B	-4558	-2030
ZNF34	-1698	-964
ZNF343	-4107	-4524
ZNF354A	1356	-4473
ZNF354C	-4069	-6378
ZNF382	-2280	-4717
ZNF394	411	-628
ZNF398	-1818	155
ZNF417	-1502	-2829
ZNF418	-2180	-6578
ZNF419	-4137	-5268
ZNF420	-3590	-3752
ZNF425	-2227	-4710
ZNF426	-1324	-3104
ZNF43	-4605	-5370
ZNF430	-1473	-4879
ZNF431	-3388	-5647
ZNF432	-4169	-5374
ZNF436	-3361	-5576
ZNF440	-3011	-5938
ZNF443	-1568	-4894
ZNF445	1126	-5606
ZNF446	-3726	-3030
ZNF461	-4647	-2540
ZNF468	-513	-4348
ZNF470	-3286	-6469
ZNF480	-1990	-4983
ZNF483	-3446	-5903
ZNF484	-3315	-304
ZNF490	-783	-2501
ZNF492	-1393	-6580
ZNF496	-4447	-3057
ZNF500	-4498	1026
ZNF506	-3256	-4344
ZNF517	-4363	-228
ZNF528	-4094	-6459
ZNF529	-3695	-3659
ZNF530	-4642	-6175
ZNF540	-3904	-4576
ZNF546	-1436	-1610
ZNF547	-1574	-4822
ZNF549	-4440	-5587
ZNF550	-4036	-5905
ZNF552	1731	-5023
ZNF554	-4534	-1275
ZNF559	-2885	-4261
ZNF561	-1293	-2945
ZNF563	-3812	-5992
ZNF564	-1352	-2468
ZNF566	-4275	-939
ZNF567	-2995	-5136
ZNF568	-4424	-6314
ZNF569	-4362	-352
ZNF570	-4449	-4872
ZNF571	-4516	-5324
ZNF573	-3242	-3023
ZNF582	-3192	-6112
ZNF583	-3431	-4848
ZNF584	-4271	-5742
ZNF585A	-2466	-4862
ZNF585B	-3890	-2710
ZNF587	-59	-1759
ZNF589	-1637	1425
ZNF596	-3558	-6669
ZNF597	-3297	-4633
ZNF600	-4299	-5453
ZNF605	-747	-1335
ZNF606	-3055	-5401
ZNF610	-1917	-6042
ZNF611	-1426	-5441
ZNF613	611	-5448
ZNF614	-3255	-2566
ZNF615	-1597	-5583
ZNF619	-3039	-6317
ZNF620	-4587	-5485
ZNF621	-4196	-3523
ZNF624	-988	-3879
ZNF627	-326	-2790
ZNF641	-2657	-5851
ZNF655	-1022	-2976
ZNF664	-3436	1571
ZNF665	-2685	-6565
ZNF668	1280	1462
ZNF670	-875	-5736
ZNF671	-2463	-680
ZNF677	-3095	-6476
ZNF678	-4128	530
ZNF681	-2855	-3353
ZNF684	-3449	-2033
ZNF688	-2649	-4023
ZNF689	-3441	-4943
ZNF691	-1949	-4147
ZNF692	-1263	-1190
ZNF696	-4484	-3058
ZNF70	-4592	-5340
ZNF700	-1440	-3707
ZNF701	-1066	-6116
ZNF703	-4175	-4320
ZNF706	-1898	-5848
ZNF707	-4438	-4401
ZNF708	-3383	-2881
ZNF709	-2918	-6445
ZNF710	2910	-6541
ZNF713	-1737	-3012
ZNF714	-987	-2480
ZNF717	-2959	-5768
ZNF736	-4428	-4463
ZNF737	-3430	-6022
ZNF74	-4652	-2918
ZNF740	-4237	878
ZNF746	3354	-3816
ZNF747	1378	-451
ZNF749	-3645	-5865
ZNF75A	-2479	-1824
ZNF761	-1712	-3885
ZNF764	-2086	-913
ZNF77	-4172	-489
ZNF771	-2367	-3926
ZNF772	-736	-5966
ZNF774	1748	-1078
ZNF775	1932	-4991
ZNF776	112	-3870
ZNF777	-2261	-4823
ZNF778	-3841	1050
ZNF782	-3133	128
ZNF785	-2212	-5042
ZNF786	-2209	56
ZNF79	-3042	470
ZNF790	-3830	-6139
ZNF791	-2511	-5116
ZNF792	-3010	645
ZNF793	-3296	-6557
ZNF799	-3658	-6025
ZNF839	-668	-6246
ZNF92	-3748	-2695
ZSCAN25	-3303	2482

---

---

Transport of small molecules

Transport of small molecules

metric	value
setSize	342
pMANOVA	1.17e-09
p.adjustMANOVA	6.57e-08
s.dist	0.205
s.RNA	0.204
s.meth	-0.0204
p.RNA	1.43e-10
p.meth	0.522

Top 20 genes

Gene	RNA	meth
TRPM2	4228	-6600
FBXL5	4384	-6189
PRKACA	4377	-6032
ATP6V0A1	4395	-5877
SLC16A3	4075	-6120
SLCO3A1	3756	-6618
MCU	4295	-5524
SLC8B1	3440	-6691
NCEH1	3988	-5550
SLC24A4	3374	-6556
SLC6A6	4119	-5316
ATP11A	3806	-5671
ASPH	4392	-4906
CYB5R4	3808	-5486
SLC2A3	4226	-4757
SGK3	3195	-6274
ATP6V0C	4207	-4697
SLC39A1	4012	-4836
CLTA	3793	-5077
PSMD6	3475	-5488

Click HERE to show all gene set members

All member genes

	RNA	meth
ABCA1	2422	-6487
ABCA2	-3827	-5284
ABCA5	-2895	-6277
ABCA7	1001	-4798
ABCB10	2344	-1135
ABCB6	2627	-6503
ABCB8	-323	-1633
ABCB9	-653	-3335
ABCC1	187	-871
ABCC10	-1498	-2526
ABCC4	3277	-3153
ABCC5	814	-2379
ABCD2	-4008	553
ABCD3	1877	-2453
ABCF1	-3429	744
ABCG1	-2674	2179
ACO1	-2877	-377
ADCY4	1985	-6389
ADCY7	-982	-5596
ADCY9	46	-2618
ADD1	2270	-89
ADD3	1300	2319
AFG3L2	-4093	-123
AHCYL2	126	-1769
AKAP1	-4228	-1116
ALAD	3905	-1369
ANKH	-4561	2518
ANO10	4291	1059
ANO6	3557	-3634
ANO7	-729	-5223
ANO8	2476	384
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
APOBR	3222	-5309
AQP11	-742	-5302
AQP3	-3260	2187
ARL2	-203	-4526
ARL2BP	-2168	-2225
ASIC1	-665	-226
ASPH	4392	-4906
ATP10A	-4778	2183
ATP10D	785	-5501
ATP11A	3806	-5671
ATP11B	2480	1806
ATP13A1	-1685	1912
ATP13A2	1072	-4240
ATP1A1	915	-365
ATP1A3	-4501	-462
ATP1B1	-3115	111
ATP1B3	-283	1223
ATP2A1	-1323	-4587
ATP2A2	3601	1489
ATP2A3	-315	1190
ATP2B4	-1545	1124
ATP2C1	1823	-1842
ATP6V0A1	4395	-5877
ATP6V0A2	-4820	689
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
ATP7B	2886	-5085
ATP8A1	-4582	-250
ATP8B2	-3842	-5387
ATP8B3	1753	-2683
ATP8B4	2974	1090
ATP9B	2224	735
BEST4	-3034	-547
BMP1	81	2278
BSG	4260	-1562
CALM1	-614	-5019
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAND1	-2049	-421
CLCN2	-273	1337
CLCN3	3158	-401
CLCN6	725	-775
CLCN7	613	-5887
CLTA	3793	-5077
CLTC	4170	2477
CTNS	2876	-4816
CUL1	-4385	-5146
CUTC	1391	1120
CYB5R1	4410	-1352
CYB5R4	3808	-5486
CYB5RL	-3922	-1109
CYBRD1	2178	-6417
DERL1	-3142	123
DERL2	1003	-2287
DERL3	-2254	-2550
EIF2S1	1555	-4266
EIF2S2	2502	-783
EMB	3084	1670
ERLEC1	246	-2711
ERLIN1	4030	899
ERLIN2	4085	-4042
FBXL5	4384	-6189
FLVCR1	-2782	-1280
FTH1	1806	-521
FTL	3959	-4621
FURIN	4236	2351
FXYD7	-2351	-6745
GLRX3	-446	1234
GNAS	3567	951
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
HDLBP	3355	-4537
HMOX2	-4584	2130
IREB2	1990	-265
KCNJ11	-1204	-2105
LDLR	2573	-494
LDLRAP1	-3040	643
LETM1	-1388	-460
LIPA	2695	587
LIPG	-366	-3956
LMF1	-3143	-2880
LMF2	-2592	-4777
LRRC8A	-2758	1064
LRRC8B	1036	-4353
LRRC8C	202	-3147
LRRC8D	1870	961
LSR	-2288	-5404
MBTPS1	951	-398
MCOLN1	3376	-5518
MCOLN2	-4511	2341
MCU	4295	-5524
MICU1	4411	2147
MICU2	-229	-4379
MRS2	-2118	-800
MYLIP	-1189	-681
NCEH1	3988	-5550
NEDD4L	3534	-5066
NEDD8	2723	-1600
NIPA1	-4296	-4370
NIPA2	1536	-3037
NIPAL1	1117	-6467
NIPAL2	568	-6187
NIPAL3	-3714	-814
NPC1	-4823	-4304
NPC2	2105	-712
NR1H2	3254	-1471
NR1H3	-1011	-2305
OS9	4053	-975
OSTM1	2965	-1606
P4HB	3824	-1549
PARL	4130	-3904
PCSK5	1809	-4883
PEX19	2296	481
PEX3	-4702	392
PHB	-914	-3178
PHB2	-77	-473
PMPCB	-265	-766
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
RAB11A	3974	-2965
RAF1	3548	-314
RNF185	2714	-2775
RNF5	-2030	-4625
RPS27A	-2186	-2138
RUNX1	3296	-4082
SAR1B	2704	489
SCARB1	2379	-4202
SCNN1A	-45	-6367
SEL1L	2854	-2307
SGK1	1695	-6076
SGK3	3195	-6274
SKP1	1561	-2290
SLC11A1	4230	-4413
SLC11A2	74	-4073
SLC12A2	-4308	-4207
SLC12A6	3687	-2521
SLC12A7	-671	-6698
SLC15A4	1337	-5940
SLC16A1	1645	576
SLC16A10	-1243	-2787
SLC16A3	4075	-6120
SLC16A7	1940	-2358
SLC17A5	1920	-3631
SLC1A4	-4300	-3680
SLC1A5	2586	-1807
SLC20A1	-4427	1152
SLC20A2	-4611	-345
SLC22A15	3958	2469
SLC22A4	4270	-1323
SLC22A5	2964	-5659
SLC24A4	3374	-6556
SLC25A22	-1975	-1050
SLC25A29	841	-595
SLC25A4	-4546	-2062
SLC26A11	-2148	-1718
SLC26A2	-879	-2627
SLC26A6	3599	-3638
SLC27A1	3788	-3528
SLC27A4	810	-6752
SLC29A1	538	-833
SLC29A2	-2949	-2510
SLC29A3	2000	2162
SLC29A4	-718	-5648
SLC2A1	-4290	1930
SLC2A11	-2176	-6205
SLC2A13	972	-5601
SLC2A3	4226	-4757
SLC2A9	2858	-6223
SLC30A1	3556	-4036
SLC30A5	-738	-2119
SLC30A6	10	-1069
SLC30A7	-1340	-2297
SLC31A1	3965	-2303
SLC33A1	-643	-2395
SLC35A1	3137	-4021
SLC35A3	-3325	-4409
SLC35B2	-3654	-2200
SLC35B3	2188	-554
SLC35B4	1209	-2370
SLC35C1	881	-5366
SLC35D1	-2160	-2789
SLC36A1	4316	-1368
SLC36A4	3150	-4355
SLC38A1	-4250	842
SLC38A2	2600	-3406
SLC39A1	4012	-4836
SLC39A10	-3440	-3874
SLC39A14	-2057	-6123
SLC39A3	1672	-5691
SLC39A4	1646	494
SLC39A6	-2583	-2106
SLC39A8	3862	-4048
SLC3A2	1969	-1667
SLC41A1	-4207	-768
SLC43A1	-1415	-1502
SLC43A2	3624	-4400
SLC44A1	3856	2368
SLC44A2	878	2003
SLC4A2	3223	-243
SLC4A7	-4617	1208
SLC50A1	1283	-6179
SLC5A3	-4224	348
SLC5A5	-1629	-5772
SLC5A6	-1663	-2437
SLC5A9	1844	888
SLC6A6	4119	-5316
SLC6A9	3274	1503
SLC7A1	-2009	754
SLC7A11	-1733	-6233
SLC7A5	1054	-6143
SLC7A6	-1921	-2873
SLC8A3	572	-5398
SLC8B1	3440	-6691
SLC9A1	3565	-753
SLC9A3	-2648	1428
SLC9A5	-2628	-6072
SLC9A8	1901	-4550
SLC9B1	-1873	1374
SLC9B2	-4257	-5310
SLCO3A1	3756	-6618
SLCO4A1	1962	-3333
SLCO4C1	1162	-1063
SMDT1	89	2068
SOAT1	3679	-4815
SPG7	-3930	-221
SRI	2759	-1804
STOM	2933	-3877
STOML2	-1218	-3256
TCIRG1	3114	-5082
TFR2	-3546	-6238
TFRC	484	-273
TPCN1	2007	-4797
TPCN2	2761	-1923
TRPC1	-3275	-2704
TRPC4AP	399	-4086
TRPM2	4228	-6600
TRPM7	-2426	-548
TRPV2	-1681	-1200
TTYH2	-1342	-6374
TTYH3	2873	-6290
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
VCP	2927	-2411
VDAC1	1532	-3624
VDAC3	150	1058
WNK1	2012	1966
WWP1	-3587	-1865
YME1L1	2443	-1525

---

---

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

metric	value
setSize	133
pMANOVA	1.37e-08
p.adjustMANOVA	7.33e-07
s.dist	0.297
s.RNA	0.29
s.meth	0.0625
p.RNA	8.19e-09
p.meth	0.215

Top 20 genes

Gene	RNA	meth
ACTN1	4259	2335
DGKG	3467	2259
GNG5	4068	1920
WDR1	2980	2364
MAPK1	3257	1865
RHOA	3688	1313
PTPN1	2276	2074
CALU	3485	1252
RAC1	3977	971
CFL1	3703	912
RHOG	3876	860
PRKCD	4146	584
PFN1	2155	833
CSK	2014	862
MANF	813	1947
PTK2	1637	920
YWHAZ	2220	541
RAP1A	3142	323
TLN1	3884	191
GNG3	288	2231

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2185	-3533
AAMP	-1094	-5298
ABCC4	3277	-3153
ABHD12	-3885	-129
ABHD6	-644	-284
ACTN1	4259	2335
ACTN4	1939	-2928
AKT1	1248	-1942
ALDOA	4289	-1349
ANXA5	3631	-2845
APBB1IP	4055	-5120
APLP2	4302	-3465
APP	4212	-5300
ARRB1	659	-6363
ARRB2	3858	-2243
BRPF3	-2021	-937
CALM1	-614	-5019
CALU	3485	1252
CAP1	3678	-553
CD63	4327	-1017
CDC37L1	-2833	1097
CDC42	3265	-2719
CFL1	3703	912
CHID1	904	-254
CRK	4109	-4581
CSK	2014	862
CYB5R1	4410	-1352
DAGLB	2332	-6635
DGKA	-2494	2375
DGKD	-165	546
DGKE	-4343	-953
DGKG	3467	2259
DGKH	-950	-6190
DGKQ	-2756	1446
DGKZ	-1727	-6294
ENDOD1	1143	-4107
FAM3C	-3567	527
FERMT3	4298	-1343
FYN	-4569	1957
GNA12	1135	-3386
GNA13	2328	-2285
GNA15	4401	-6690
GNAI2	3614	-1747
GNAI3	3575	-909
GNAQ	4150	-6733
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GRB2	4321	-2295
GTPBP2	2596	-487
HABP4	-4095	230
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
LCK	-4404	2489
LCP2	-357	1588
MANF	813	1947
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
NHLRC2	-2578	-716
OLA1	1868	-508
P2RY1	3509	-5377
PCYOX1L	-587	339
PDPK1	2505	167
PFN1	2155	833
PHACTR2	2128	-6672
PIK3CA	1725	-1445
PIK3CG	646	-2045
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R5	-695	514
PLCG2	1926	-2562
PLEK	667	-5891
PPIA	-2188	490
PRKCA	368	810
PRKCB	2983	-4518
PRKCD	4146	584
PRKCE	-2656	-5632
PRKCH	-4848	1376
PRKCQ	-4731	1372
PRKCZ	-4414	-5220
PSAP	2899	-4192
PTK2	1637	920
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN6	2483	-4586
QSOX1	4308	-1087
RAC1	3977	971
RAC2	1994	-868
RAF1	3548	-314
RAP1A	3142	323
RAP1B	1106	-1031
RASGRP1	-4601	2119
RASGRP2	-2706	1508
RHOA	3688	1313
RHOB	378	-4992
RHOG	3876	860
SCCPDH	3498	-5477
SHC1	1469	-2954
SOD1	-1490	-1019
SOS1	-1758	-6775
SRC	-3100	-4427
SRGN	4017	-2722
STX4	200	-6001
STXBP2	4178	-6352
STXBP3	3213	-1306
SYK	4194	-5054
TAGLN2	3219	-1136
TEX264	-2862	55
TGFB1	1971	-6
TGFB2	-2458	-6761
TGFB3	-2516	-5946
TLN1	3884	191
TMX3	-255	-6313
TOR4A	4106	-6704
TUBA4A	2717	-4571
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCL	3178	-5870
VEGFA	3184	-2723
VTI1B	4081	-359
WDR1	2980	2364
YWHAZ	2220	541

---

---

Infectious disease

Infectious disease

metric	value
setSize	486
pMANOVA	1.72e-08
p.adjustMANOVA	8.77e-07
s.dist	0.154
s.RNA	0.112
s.meth	0.105
p.RNA	2.88e-05
p.meth	9.3e-05

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
FURIN	4236	2351
ENTPD1	3776	2446
ANTXR2	3207	2471
GNG5	4068	1920
ACTG1	3946	1793
MYH9	2818	2182
MAPK1	3257	1865
BRD4	2362	2511
BRK1	3002	1970
PSMA7	3060	1752
PSMD1	3121	1660
TAF10	3073	1606
CHMP1A	2294	2118
CBL	3300	1456
CORO1A	1975	2237
PSME3	3757	1116
VPS25	3359	1235
NUP214	3562	1119
PSTPIP1	3510	1135

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ADAM17	3540	774
ADCY4	1985	-6389
ADCY7	-982	-5596
ADCY9	46	-2618
ADM	4381	-6151
ADORA2A	1055	-5935
ADRB2	-4638	-3531
AHCYL1	2655	-3553
ANTXR2	3207	2471
AP1B1	3990	-463
AP1G1	1421	516
AP1M1	2828	-2408
AP1S3	-1711	-5455
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
ARF1	4190	-6686
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ATP1A1	915	-365
ATP6V1H	3629	-1695
B2M	-2236	-2389
BAIAP2	-56	1977
BANF1	-1462	-709
BECN1	2625	459
BRD4	2362	2511
BRK1	3002	1970
BTRC	-1491	-2427
C3AR1	3600	-6729
CALM1	-614	-5019
CALR	2620	-3753
CANX	2138	-4839
CASP1	1434	-1448
CBL	3300	1456
CBX1	1756	-1720
CCNH	249	-3754
CCNK	942	-6142
CCNT1	-3342	1773
CD247	-4870	2098
CD4	-1631	-6372
CDC42	3265	-2719
CDK7	2020	275
CDK9	-1184	1524
CEBPD	4041	-5142
CHMP1A	2294	2118
CHMP2A	4065	-297
CHMP2B	2237	-4000
CHMP3	3762	-2694
CHMP4A	794	458
CHMP4B	4045	-4297
CHMP5	1842	-2010
CHMP6	2172	-2539
CHMP7	-2791	-1608
CLTA	3793	-5077
CLTC	4170	2477
COMT	3713	-6677
CORO1A	1975	2237
CPSF4	-3362	134
CRBN	-1934	919
CREB1	-423	-672
CRK	4109	-4581
CTDP1	2551	1112
CTNNB1	2647	-1691
CTNND1	-2884	1566
CTSL	1667	-6671
CUL5	269	-3077
CXCR4	-37	-1660
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
DAXX	-3887	-450
DBP	-4352	-1027
DDX5	-3458	1288
DNAJC3	3833	-2353
DPEP2	-826	-6530
DUSP16	-2084	-2622
DUT	-1868	1287
DVL1	19	-4520
DVL2	-3982	-1356
DVL3	2248	-3704
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
EED	-3277	-1174
EEF2	93	2127
EIF2AK2	-3267	-3645
ELL	1902	574
ELMO1	2569	-2714
ELMO2	1638	1326
ENO1	4071	-6654
ENTPD1	3776	2446
ENTPD5	-1942	-4305
EPS15	1476	-654
ERCC2	1202	-594
ERCC3	-2537	969
EZH2	-3517	-20
FAU	-129	-3862
FEN1	-3976	-56
FGR	3790	-5292
FKBP1A	4177	-4465
FURIN	4236	2351
FYN	-4569	1957
FZD7	-2029	-3834
GANAB	-316	-3501
GGT1	4400	-6607
GIPR	-4760	-2380
GNAI2	3614	-1747
GNAI3	3575	-909
GNAS	3567	951
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GPS2	-290	-857
GRB2	4321	-2295
GRSF1	1991	27
GSK3A	3432	-2192
GSK3B	2793	736
GTF2A1	884	271
GTF2A2	3083	-1036
GTF2B	1223	-3218
GTF2E2	2305	-184
GTF2F1	1892	-1723
GTF2F2	2127	-2885
GTF2H3	-664	1025
GTF2H4	-874	-2761
GTF2H5	1343	691
HBEGF	1808	-6428
HDAC2	2158	-46
HDAC3	1740	-3771
HGS	1660	2123
HLA-A	-768	-5991
HMGA1	24	802
HNRNPK	3313	-2386
HRH2	4409	-6490
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSPA1A	3666	-3825
IL1RAP	3160	-456
IL6R	3697	-6410
IMPDH1	4348	-750
IMPDH2	-3359	446
IPO5	-3937	1869
IRS1	563	-4060
ISG15	-4761	1894
ITGA4	-4108	1419
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JAK1	-4154	-1022
JAK2	834	-1751
JUN	1372	69
KPNA1	409	-2889
KPNA2	-2167	-874
KPNA3	308	-897
KPNA4	1912	1716
KPNA5	-4625	-572
KPNB1	799	-2176
LCK	-4404	2489
LIG1	-3821	-4259
LIG4	2068	-949
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK8	-3380	6
MGAT1	2494	1169
MNAT1	-3019	311
MOGS	-919	-2356
MVB12A	3203	272
MYH9	2818	2182
MYO9B	2658	687
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCK1	-4400	-1408
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NCOR1	2375	-3738
NCOR2	3521	-4281
NDC1	-4771	-5228
NEDD4L	3534	-5066
NELFA	-1150	35
NELFB	121	1822
NELFCD	-1955	2444
NELFE	1359	1377
NFKB2	-279	388
NLRP3	4033	-6357
NMT1	1591	-3001
NMT2	-4662	1340
NOXA1	-1687	-5872
NR3C1	190	-2420
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
P2RX4	3391	174
PABPN1	-170	-3743
PACS1	-2828	-4252
PAK2	3694	-3961
PARP1	-4461	-5521
PARP10	-2831	2302
PARP14	-4650	864
PARP16	-4459	678
PARP4	1531	-715
PARP6	-1500	-3268
PARP8	-2888	-759
PARP9	-1402	1117
PDCD6IP	2715	-3917
PIK3R4	-1199	-3425
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLK2	-832	-6257
PML	-3036	549
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POM121	-2762	-1787
POM121C	-2356	-4315
PPIA	-2188	490
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PRKCSH	2022	-3007
PSIP1	-3456	-4249
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PSTPIP1	3510	1135
PTGER2	447	-5853
PTGER4	-4573	1153
PTK2	1637	920
PYCARD	3986	-6598
RAB5A	3055	-1686
RAB7A	4011	-5570
RAC1	3977	971
RAE1	1948	-39
RAN	-2179	1257
RANBP1	-3483	-2212
RANBP2	-259	-4704
RANGAP1	-4514	1644
RB1	3934	-4740
RBBP4	-573	-3282
RBX1	1413	-3241
RCC1	531	-1845
RELA	-541	2085
RHBDF2	1487	-4959
RNF213	-4661	2228
RNGTT	976	-2952
RNMT	-4236	2172
ROCK1	3215	-985
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
S1PR1	-3197	2436
SEC13	2286	-3749
SEH1L	-1833	-1615
SFPQ	733	-1117
SH3GL1	3385	1075
SIGMAR1	-2520	306
SKP1	1561	-2290
SLC25A4	-4546	-2062
SNF8	2382	-2157
SRC	-3100	-4427
SSRP1	-4239	-2441
ST3GAL1	-2411	1767
ST3GAL2	4018	-2686
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST6GAL1	-4644	1948
ST6GALNAC3	4287	145
ST6GALNAC4	-268	-5981
STAM	404	770
STAM2	2488	-2181
STX1A	-1208	-2461
STX1B	-888	-6167
SUGT1	483	594
SUMO1	2937	-3986
SUPT16H	-4379	-3702
SUPT4H1	966	-1899
SUPT5H	-2124	-3641
SYK	4194	-5054
TAF10	3073	1606
TAF11	-873	-719
TAF12	3604	-1765
TAF13	3147	-908
TAF15	-2044	-3109
TAF2	-1849	-4149
TAF3	-546	-3002
TAF4	-518	-6161
TAF4B	-2590	-1647
TAF5	-1331	1150
TAF6	-2393	1804
TAF7	625	-3426
TAF9	390	1714
TBK1	1029	-4616
TBL1XR1	1687	962
TCEA1	-301	-4211
TGFB1	1971	-6
TLR2	4180	-6586
TLR9	-1815	2292
TPR	-2272	-973
TRIM27	3711	-1744
TRIM28	-1482	1191
TSG101	3465	-5032
TUBB	-2260	1395
TXN	3798	284
TXNIP	-3453	-2777
TXNRD1	3738	-4647
TYK2	3075	-3105
UBA52	344	752
UBAP1	4015	-2481
UBB	2801	-1321
UBC	1599	-2568
UBE2I	-239	233
UVRAG	-3183	-3344
VAMP1	-2507	-1537
VAMP2	-4530	-2770
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VCP	2927	-2411
VEGFA	3184	-2723
VHL	1285	1389
VIPR1	-1885	-3480
VPS25	3359	1235
VPS28	1503	-2471
VPS33B	-598	-2464
VPS36	-2208	-2008
VPS37A	2702	-3512
VPS37B	1362	-6110
VPS37C	3535	421
VPS4A	247	118
VTA1	2518	-3898
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WIPF1	182	-4382
WIPF2	2264	-2523
XPO1	-371	-870
XRCC4	2832	-3706
XRCC5	2099	-3770
XRCC6	-1338	376
YES1	-4790	-4415
ZCRB1	219	2291

---

---

Cellular responses to external stimuli

Cellular responses to external stimuli

metric	value
setSize	397
pMANOVA	2.58e-08
p.adjustMANOVA	1.26e-06
s.dist	0.168
s.RNA	0.122
s.meth	0.115
p.RNA	3.95e-05
p.meth	1e-04

Top 20 genes

Gene	RNA	meth
MAP4K4	3853	2014
PHC2	4201	1830
DNAJB6	3591	1923
ATP6V1A	4307	1580
ATP6V0B	3961	1604
LAMTOR2	3365	1882
BAG1	2645	2301
MAPK1	3257	1865
PSMA7	3060	1752
FOS	2486	2149
PSMD1	3121	1660
CBX8	2136	2207
AGO1	2205	1997
UBE2S	1785	2449
PRDX3	4355	972
PSME3	3757	1116
ARNT	3603	1140
DNAJA2	2208	1824
NUP214	3562	1119
CSRP1	3338	1181

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ACD	-2500	-5810
ACTR10	3334	-1291
ACTR1A	3003	-1
AGO1	2205	1997
AGO3	-318	-6442
AJUBA	-2581	-2301
AKT1S1	3491	-2319
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC15	4157	-1379
ANAPC16	-645	-4507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
ARNT	3603	1140
ASNS	-2777	12
ATF3	-3533	-4121
ATF4	2565	-956
ATF5	-1651	-722
ATM	-4028	202
ATOX1	1607	-5343
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
ATR	-3783	970
BAG1	2645	2301
BAG2	-2453	-2208
BAG3	-948	423
BAG4	3782	-3089
BAG5	-1485	-4477
BMI1	-3450	-6383
C12orf66	-4090	-3658
CABIN1	-3797	-2517
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CAT	4221	-3922
CBX4	706	-5288
CBX6	1438	-3511
CBX8	2136	2207
CCAR2	-3702	2391
CCNA2	521	-1132
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCS	423	102
CDC16	-1863	-4152
CDC23	-4319	-707
CDK2	-1524	1018
CDK4	-4195	-1295
CDK6	-1983	-2864
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDKN2A	-1623	-4511
CDKN2C	2963	-130
CDKN2D	3554	308
CEBPB	3621	-5089
CEBPG	2149	1702
CITED2	2650	-104
CREBBP	1169	-5804
CSRP1	3338	1181
CUL2	821	-1212
CYBA	2925	1006
CYCS	-386	-3927
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DDIT3	1835	-3177
DEDD2	1115	1927
DEPDC5	37	-4322
DNAJA1	2118	-1834
DNAJA2	2208	1824
DNAJA4	-281	2305
DNAJB1	-1723	-3687
DNAJB6	3591	1923
DNAJC2	-1518	-1772
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
E2F1	2654	-1005
E2F2	4026	386
E2F3	2805	-2884
EED	-3277	-1174
EEF1A1	-1543	720
EGLN1	2782	-6231
EGLN2	1184	-3619
EHMT1	-2969	-1697
EHMT2	-2882	-1059
EIF2AK1	3869	1012
EIF2AK4	45	-5466
EIF2S1	1555	-4266
EIF2S2	2502	-783
EP300	2504	-4509
EP400	-2035	1434
EPAS1	3555	535
ERF	1596	-683
ERO1A	4059	-4535
ETS1	-4302	2277
ETS2	3572	-5483
EZH2	-3517	-20
FAU	-129	-3862
FKBP4	253	-4442
FKBP5	4105	-5653
FLCN	1241	708
FNIP1	2212	355
FOS	2486	2149
FZR1	-666	-758
GCN1	-3719	-6714
GPX1	4356	-5467
GRB10	4408	-70
GSK3B	2793	736
GSR	4279	-4724
GSTP1	62	-5415
HIF1A	3192	-3349
HIF1AN	-1365	-1051
HIGD1A	3226	-4744
HIRA	-3473	-860
HMGA1	24	802
HSBP1	3667	-3338
HSF1	2462	1452
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSPA13	-355	-1732
HSPA14	-3352	866
HSPA1A	3666	-3825
HSPA1B	2667	-513
HSPA1L	1008	885
HSPA2	3087	-271
HSPA4	2078	963
HSPA4L	-696	-5898
HSPA9	-3551	-200
HSPH1	-3193	993
ID1	1788	-3980
ITFG2	-3941	-873
JUN	1372	69
KAT5	419	-650
KDM6B	3966	-92
KPTN	2585	1279
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAMTOR4	1631	-6150
LAMTOR5	3910	-5095
LIMD1	-4087	-6080
LMNB1	4362	-942
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K5	3379	-4989
MAP4K4	3853	2014
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MDM2	1471	-1318
MDM4	-377	-2440
MINK1	1278	-4004
MIOS	1147	561
MLST8	98	287
MOV10	-4691	-6449
MRPL18	678	-1383
MT1F	3370	-4560
MT1X	2129	-2005
MT2A	-2299	1556
MTF1	4099	-2992
MTOR	-3531	-1813
NBN	710	750
NCF4	4349	-6732
NDC1	-4771	-5228
NPRL2	-4368	2371
NPRL3	1659	2138
NR3C1	190	-2420
NR3C2	-3730	324
NUDT2	1000	-2046
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
P4HB	3824	-1549
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
POM121	-2762	-1787
POM121C	-2356	-4315
PPP1R15A	2403	-5399
PRDX1	3015	-877
PRDX2	1172	-5158
PRDX3	4355	972
PRDX5	3911	-1661
PRDX6	4128	916
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTGES3	1472	-1810
RAD50	-2424	2067
RAE1	1948	-39
RANBP2	-259	-4704
RB1	3934	-4740
RBBP4	-573	-3282
RBX1	1413	-3241
RELA	-541	2085
RHEB	3346	-2334
RING1	-1202	-1490
RNF2	1210	-1936
RPA1	-4680	-2495
RPA3	-3097	-1890
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS19BP1	869	436
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RPTOR	-3833	2134
RRAGA	2580	-1657
RRAGC	1887	-2585
RRAGD	4056	-6311
SCMH1	-1695	1397
SEC13	2286	-3749
SEH1L	-1833	-1615
SERPINH1	-3655	-1891
SESN1	-3131	-3887
SESN2	1227	-3423
SIRT1	-1251	-1775
SLC38A9	920	-3360
SOD1	-1490	-1019
SOD2	1617	573
SP1	3746	-3141
ST13	-391	-5101
STAT3	3649	-3606
STIP1	-648	31
SZT2	-1603	-5754
TCIRG1	3114	-5082
TERF1	-1048	-1932
TERF2	-1349	982
TERF2IP	1931	-4579
TFDP1	3847	-1587
TFDP2	-4878	-4793
TINF2	1711	-1513
TNIK	-4483	-2132
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TP53	-4078	-739
TPR	-2272	-973
TRIB3	-1812	1669
TXN	3798	284
TXN2	1737	-257
TXNRD1	3738	-4647
TXNRD2	3275	-5499
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2S	1785	2449
UBN1	2080	-3899
VCP	2927	-2411
VEGFA	3184	-2723
VHL	1285	1389
WDR24	359	-6152
WDR59	-3112	-1721
YWHAE	4144	-4168

---

---

Asparagine N-linked glycosylation

Asparagine N-linked glycosylation

metric	value
setSize	223
pMANOVA	2.83e-08
p.adjustMANOVA	1.32e-06
s.dist	0.228
s.RNA	0.227
s.meth	0.0207
p.RNA	6.33e-09
p.meth	0.597

Top 20 genes

Gene	RNA	meth
KDELR1	4237	1780
TMED7	3495	1939
DAD1	2384	2452
PPP6C	2885	2020
GLB1	3936	1368
GOLGA2	2510	1847
COPA	3748	1056
TSTA3	2570	1496
MGAT1	2494	1169
DCTN6	3179	819
ALG14	2290	1103
PDIA3	1468	1466
CAPZA1	3657	572
NANS	3512	529
USO1	1479	1196
SAR1B	2704	489
CTSC	817	1561
MLEC	742	953
SRD5A3	1437	442
COPE	2941	213

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTR10	3334	-1291
ACTR1A	3003	-1
ALG10	-2612	-346
ALG10B	-2684	966
ALG11	-1076	-549
ALG12	852	-1300
ALG14	2290	1103
ALG2	-422	-625
ALG3	-387	-2680
ALG5	-216	-2175
ALG6	508	-4449
ALG8	-1089	-3591
ALG9	-3466	-1148
AMDHD2	-3916	539
AMFR	3220	-6742
ANK1	4083	-4221
ANK3	-1508	-6563
ANKRD28	-1964	-5108
ARCN1	2206	-1676
ARF1	4190	-6686
ARF3	3423	-1912
ARF4	4255	-3280
ARF5	3536	-4789
ARFGAP1	-583	1688
ARFGAP3	1308	-5386
B4GALT1	1562	-160
B4GALT2	-1893	1307
B4GALT3	-3906	-4680
B4GALT4	185	-1422
B4GALT5	4092	52
B4GALT6	-3085	-6484
BET1	-202	-4482
BET1L	-2386	332
CALR	2620	-3753
CANX	2138	-4839
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CD55	4233	-3923
CD59	2365	-6024
CHST10	-4624	-5927
CMAS	4029	-2712
CNIH1	3446	-6699
COG1	-4741	-3663
COG2	-2655	-6132
COG3	-1593	-5701
COG4	1	-984
COG5	-985	-1864
COG6	-1803	-358
COG7	1546	-4196
COG8	-131	1846
COPA	3748	1056
COPB1	3188	-1329
COPB2	3530	-1501
COPE	2941	213
COPZ1	1431	-5051
COPZ2	-4133	1305
CSNK1D	771	-1777
CTSA	4423	-4847
CTSC	817	1561
CTSZ	4137	-6765
DAD1	2384	2452
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DERL1	-3142	123
DERL2	1003	-2287
DHDDS	-625	-4895
DOLK	-1093	-2245
DOLPP1	930	-914
DPAGT1	690	650
DPM1	488	-2366
DPM2	1768	-1939
DPM3	827	-2637
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
EDEM1	-41	1523
EDEM2	4014	-3093
ENGASE	-2201	-5741
FPGT	3174	-2826
FUCA1	3251	-5579
FUOM	-1587	-5803
FUT8	-3435	-2455
GANAB	-316	-3501
GBF1	-1292	-120
GFPT1	-2050	-2828
GLB1	3936	1368
GMDS	1860	-1375
GMPPA	1360	-4201
GMPPB	-2292	1238
GNE	-1601	-4921
GNPNAT1	-3357	-2849
GOLGA2	2510	1847
GOLGB1	-1656	-3196
GORASP1	2763	-2178
GOSR1	-51	-3152
GOSR2	-462	1643
KDELR1	4237	1780
KDELR2	3293	-2980
LMAN1	-3951	596
LMAN2	3064	-2497
LMAN2L	2953	-1590
MAN1A1	3539	-447
MAN1A2	-601	-1465
MAN1B1	-1489	2249
MAN1C1	-2013	-1205
MAN2A1	-406	-4486
MAN2A2	2762	-5172
MANEA	-207	172
MCFD2	3037	-158
MGAT1	2494	1169
MGAT2	519	-1666
MGAT4A	-1692	-2254
MGAT4B	3991	-6439
MGAT5	-941	-5572
MIA3	-1970	-3428
MLEC	742	953
MOGS	-919	-2356
MPDU1	3420	-1260
MPI	-3671	-5890
MVD	-1820	1954
NAGK	1045	-5552
NANP	-3397	-585
NANS	3512	529
NAPA	425	-4125
NAPB	-827	471
NAPG	1477	-97
NEU1	4191	-3878
NEU3	-1129	-1409
NGLY1	-1111	-236
NPL	4422	-6573
NUS1	3489	-9
OS9	4053	-975
PDIA3	1468	1466
PGM3	-250	1964
PMM1	1492	-1060
PMM2	439	-2687
PPP6C	2885	2020
PPP6R1	2037	-1276
PPP6R3	1102	-3726
PRKCSH	2022	-3007
PSMC1	3011	-5705
RAB1A	4185	-1703
RAB1B	3794	-264
RAD23B	4100	-3906
RFT1	1565	147
RNF103	-1377	-2036
RNF139	866	354
RNF185	2714	-2775
RNF5	-2030	-4625
RPN1	3560	-2841
RPN2	3036	-688
RPS27A	-2186	-2138
SAR1B	2704	489
SEC13	2286	-3749
SEC16A	1717	-1722
SEC22A	-1547	696
SEC22C	-1274	1879
SEC23A	3198	-5141
SEC23IP	-149	-38
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SEL1L	2854	-2307
SLC17A5	1920	-3631
SLC35A1	3137	-4021
SLC35C1	881	-5366
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SRD5A3	1437	442
ST3GAL1	-2411	1767
ST3GAL2	4018	-2686
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST3GAL5	-4489	1507
ST3GAL6	2764	-5427
ST6GAL1	-4644	1948
ST6GALNAC3	4287	145
ST6GALNAC4	-268	-5981
ST6GALNAC6	-4677	2144
ST8SIA1	-2619	-2246
ST8SIA4	3717	-3013
STT3A	1453	-4222
STX17	-4112	-4247
STX5	3070	-1823
SYVN1	322	-5153
TBC1D20	-16	-5205
TGFA	4154	-3020
TMED10	104	604
TMED2	2437	-3656
TMED3	893	-2936
TMED7	3495	1939
TMED9	3079	-1992
TMEM115	2179	-703
TRAPPC1	3480	-3029
TRAPPC10	-3321	2388
TRAPPC2L	-690	1441
TRAPPC3	3050	-2853
TRAPPC4	-2164	-3231
TRAPPC5	2001	-5629
TRAPPC6A	-4070	1765
TRAPPC6B	1486	-662
TRAPPC9	2076	-4354
TRIM13	-684	497
TSTA3	2570	1496
UAP1	-4800	-3110
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBXN1	597	-2222
UGGT1	1936	-3498
USO1	1479	1196
VCP	2927	-2411
YKT6	2009	-3331

---

---

EPH-Ephrin signaling

EPH-Ephrin signaling

metric	value
setSize	55
pMANOVA	4.44e-08
p.adjustMANOVA	1.99e-06
s.dist	0.462
s.RNA	0.448
s.meth	-0.112
p.RNA	9.5e-09
p.meth	0.153

Top 20 genes

Gene	RNA	meth
LIMK2	3673	-6093
CLTCL1	4107	-4995
CLTA	3793	-5077
ACTB	4172	-4515
NCSTN	4222	-3821
ARPC5	3937	-3837
PAK1	3707	-3995
PAK2	3694	-3961
ARPC3	3741	-3767
AP2A1	2735	-4887
PSEN1	3454	-3407
AP2S1	3606	-3262
VAV3	1853	-6342
ARPC2	3217	-3647
ACTR2	3442	-3374
SDCBP	4350	-2535
ACTR3	3481	-2917
CLTB	2497	-3627
APH1A	1483	-6066
CDC42	3265	-2719

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ADAM10	3964	976
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
APH1A	1483	-6066
APH1B	2525	2056
ARHGEF7	-1390	-5507
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
CDC42	3265	-2719
CFL1	3703	912
CLTA	3793	-5077
CLTB	2497	-3627
CLTC	4170	2477
CLTCL1	4107	-4995
DNM1	1196	-5619
EFNA3	-2669	568
EFNA4	2511	-3312
EFNB2	-1951	-5564
EPHA4	-4171	630
EPHB6	58	-5408
FYN	-4569	1957
GIT1	-3313	-6740
HRAS	-989	-4780
ITSN1	4248	-1048
LIMK1	1743	-3787
LIMK2	3673	-6093
MYH10	214	-4405
MYH9	2818	2182
MYL12A	2942	-2655
MYL6	3953	-19
NCK2	1874	-4310
NCSTN	4222	-3821
PAK1	3707	-3995
PAK2	3694	-3961
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PTK2	1637	920
RAC1	3977	971
RASA1	674	-167
RHOA	3688	1313
ROCK1	3215	-985
SDCBP	4350	-2535
SRC	-3100	-4427
VAV2	-1215	-643
VAV3	1853	-6342
WASL	91	-4742
YES1	-4790	-4415

---

---

RNA Polymerase II Transcription

RNA Polymerase II Transcription

metric	value
setSize	895
pMANOVA	5.89e-08
p.adjustMANOVA	2.54e-06
s.dist	0.114
s.RNA	-0.109
s.meth	-0.0335
p.RNA	7.75e-08
p.meth	0.0991

Top 20 genes

Gene	RNA	meth
MOV10	-4691	-6449
ZNF530	-4642	-6175
ZKSCAN8	-4216	-6728
ZNF568	-4424	-6314
AUTS2	-4756	-5652
ZNF528	-4094	-6459
ZNF354C	-4069	-6378
CCND2	-4504	-5700
ZNF211	-4244	-6023
ZNF620	-4587	-5485
ERBB2	-4860	-5145
ZNF549	-4440	-5587
ZNF43	-4605	-5370
CNOT6L	-4344	-5686
PARP1	-4461	-5521
ZNF584	-4271	-5742
ZNF70	-4592	-5340
PIP4K2C	-4341	-5573
ZNF287	-4733	-5090
ZNF571	-4516	-5324

Click HERE to show all gene set members

All member genes

	RNA	meth
ABL1	69	-4891
ACTL6A	-2395	-4851
AFF4	427	-5010
AGO1	2205	1997
AGO2	983	2447
AGO3	-318	-6442
AKT1	1248	-1942
AKT2	108	-141
ALYREF	2121	-4902
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC15	4157	-1379
ANAPC16	-645	-4507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
APAF1	4182	-2104
ARID1A	1819	-6716
ARID1B	-1691	1093
ARID2	-1177	-657
ARID3A	3916	-4723
ASH2L	2381	-3791
ATAD2	-4041	-1835
ATM	-4028	202
ATR	-3783	970
ATRIP	-4340	-2737
ATXN3	502	1703
AURKA	1188	-385
AURKB	309	-889
AUTS2	-4756	-5652
AXIN1	-3733	-5655
BANP	208	-4163
BARD1	-1018	-2910
BAX	2386	-3623
BBC3	-2642	-3845
BCL2L11	3144	1781
BCL6	4305	-299
BID	2427	844
BIRC5	1432	-84
BLM	-1434	-2909
BMI1	-3450	-6383
BNIP3L	4325	-851
BRCA1	2537	-4609
BRD1	-4083	2465
BRD2	-3312	1256
BRD7	-12	-5008
BRIP1	-4545	-2323
BRPF1	-2320	89
BRPF3	-2021	-937
BTG1	-1579	2084
BTG2	922	-1900
CALM1	-614	-5019
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAMK4	-3176	1482
CASC3	2017	-2580
CASP1	1434	-1448
CASP10	-1033	-6612
CASP6	-862	-4898
CAT	4221	-3922
CAV1	584	-2432
CBFB	680	-3766
CBX3	1810	-859
CBX4	706	-5288
CBX6	1438	-3511
CBX8	2136	2207
CCNA2	521	-1132
CCNB1	144	1492
CCNC	596	-1138
CCND1	-2169	-6213
CCND2	-4504	-5700
CCND3	3252	905
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCNG1	1839	131
CCNG2	2810	-3720
CCNH	249	-3754
CCNK	942	-6142
CCNT1	-3342	1773
CDC16	-1863	-4152
CDC23	-4319	-707
CDC25C	1885	-2877
CDC40	2856	2242
CDC7	-2607	-202
CDC73	1921	-2092
CDK1	454	-4215
CDK12	-417	-805
CDK13	-2893	-700
CDK2	-1524	1018
CDK4	-4195	-1295
CDK5	3942	-506
CDK5R1	-356	-2113
CDK6	-1983	-2864
CDK7	2020	275
CDK8	-597	-5509
CDK9	-1184	1524
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDKN2A	-1623	-4511
CEBPB	3621	-5089
CENPJ	-4301	-838
CHD3	-3299	422
CHD4	-1372	-4634
CHEK1	-752	-211
CHEK2	-1306	-2709
CITED2	2650	-104
CITED4	3297	-701
CLP1	2775	-1417
CNOT1	-1283	-4543
CNOT10	-800	-361
CNOT11	661	-2236
CNOT3	2060	565
CNOT4	-392	-3064
CNOT6	1776	-3728
CNOT6L	-4344	-5686
CNOT7	-1157	349
CNOT8	3743	-2054
COX11	-4162	-789
COX14	-463	-3835
COX16	66	-1160
COX19	-2202	-4047
COX20	-1528	-4841
COX4I1	1505	-5506
COX5A	2520	-2944
COX5B	2572	382
COX6A1	1958	-961
COX6B1	2260	-2634
COX6C	228	-1411
COX7A2L	3430	-2476
COX7C	178	-4071
COX8A	2789	-1258
CPSF1	-1130	-6284
CPSF2	3479	-3164
CPSF3	2696	-4860
CPSF4	-3362	134
CRADD	2031	-4017
CREB1	-423	-672
CREBBP	1169	-5804
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CSTF1	-1905	2021
CTDP1	2551	1112
CTLA4	-3873	2506
CTNNB1	2647	-1691
CTR9	1123	-5535
CTSL	1667	-6671
CTSV	-848	-5834
CUL1	-4385	-5146
CYCS	-386	-3927
DAXX	-3887	-450
DDB2	-4468	-561
DDIT3	1835	-3177
DDIT4	-502	-2588
DEK	854	1060
DGCR8	-4603	-495
DNA2	-871	-2087
DPY30	1310	-1010
DYRK2	-4396	-3036
E2F1	2654	-1005
E2F4	2607	-172
E2F5	-2781	-2646
E2F6	-1495	-2466
E2F7	-1816	-1622
E2F8	926	-4363
EAF1	2180	-4156
EED	-3277	-1174
EHMT1	-2969	-1697
EHMT2	-2882	-1059
EIF4A3	3171	-3850
ELF1	515	-1733
ELF2	847	-3373
ELL	1902	574
ELL2	3490	-3578
ELL3	20	-2569
EP300	2504	-4509
EPC1	-3604	-2797
ERBB2	-4860	-5145
ERCC2	1202	-594
ERCC3	-2537	969
ESR2	-3196	-2661
ESRRA	2370	-2927
EXO1	-481	-3123
EZH2	-3517	-20
FANCC	-4387	-3902
FANCD2	-4393	1778
FANCI	-4672	-4622
FAS	1270	-5824
FBXO32	-4006	-1875
FBXW7	-2109	-5428
FIP1L1	-2679	-2274
FKBP5	4105	-5653
FOS	2486	2149
FOXO1	-3171	-5036
FOXO3	3983	711
FYTTD1	-1788	1459
FZR1	-666	-758
GADD45A	4281	-2249
GATA3	-4787	1861
GATAD2A	1016	-256
GATAD2B	-535	-2871
GLS	-4521	-4781
GPAM	-3559	-4630
GPI	2523	-2211
GPS2	-290	-857
GSK3B	2793	736
GSR	4279	-4724
GTF2A1	884	271
GTF2A2	3083	-1036
GTF2B	1223	-3218
GTF2E2	2305	-184
GTF2F1	1892	-1723
GTF2F2	2127	-2885
GTF2H3	-664	1025
GTF2H4	-874	-2761
GTF2H5	1343	691
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HEY2	-3510	2330
HIPK1	2327	-974
HIPK2	2508	-1520
HIVEP3	-842	2288
HSPD1	-543	-2021
HUS1	-40	-522
ICE2	-2994	1344
IL2RA	-2353	-6462
ING2	1592	-2115
ING5	-3556	-763
INTS1	243	-1451
INTS10	1552	-1477
INTS12	84	1798
INTS2	-588	-5323
INTS3	2562	1491
INTS4	-3150	-2255
INTS5	-330	-2452
INTS6	2258	-1482
INTS7	-2650	-3259
INTS8	3674	-1509
INTS9	-2085	-2341
ITCH	429	-1366
ITGA4	-4108	1419
ITGA5	3362	-6767
ITGAL	-4114	2268
IWS1	2349	-60
JMY	-4347	-4364
JUN	1372	69
JUNB	2887	-3031
KAT2A	-3767	-5050
KAT2B	-704	-1588
KAT5	419	-650
KCTD1	-558	-6296
KCTD6	1605	886
KMT2A	-3933	2484
KMT2C	22	-6379
KMT2D	1065	-6199
KMT2E	-1909	2390
KRAS	1294	440
L3MBTL2	-3980	-4114
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAMTOR4	1631	-6150
LAMTOR5	3910	-5095
LBR	3693	-3506
LDB1	-3409	1270
LEO1	26	791
LMO2	3759	-5492
LRPPRC	-3636	-5728
LSM10	2631	-3871
LSM11	-3703	-4172
MAF	-3921	-4350
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAP2K6	4145	-1130
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPKAP1	1937	1057
MAX	1522	-3235
MBD3	-172	1673
MDC1	-4696	-902
MDM2	1471	-1318
MDM4	-377	-2440
MEAF6	-2755	-3609
MED1	-1217	-2271
MED10	-2937	-2572
MED13	824	590
MED15	-3549	2114
MED16	2032	1719
MED17	967	-1418
MED20	2864	-542
MED23	-2103	633
MED24	-2416	-2701
MED25	2547	-1286
MED26	1615	18
MED27	-3240	-960
MED30	-1688	491
MED31	456	445
MED4	1079	-4472
MED6	-284	560
MED7	55	778
MED8	3319	1289
MEN1	-2763	-2311
MGA	-3539	-3489
MLLT1	3488	-1901
MLLT3	-3400	1273
MLST8	98	287
MNAT1	-3019	311
MOV10	-4691	-6449
MSH2	-4317	83
MTA2	-2378	1649
MTOR	-3531	-1813
MYB	176	1502
NABP1	3622	-209
NABP2	-2385	-6524
NBN	710	750
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCOR1	2375	-3738
NCOR2	3521	-4281
NDRG1	1714	149
NDUFA4	2716	288
NEDD4L	3534	-5066
NELFA	-1150	35
NELFB	121	1822
NELFCD	-1955	2444
NELFE	1359	1377
NFATC2	-4839	2414
NFE2	4398	-6723
NFYA	1190	1464
NFYB	-3535	-531
NFYC	3381	-3078
NOP2	-3314	-2438
NOTCH1	1739	1722
NOTCH4	-1578	-6455
NR1D1	-2922	1187
NR1D2	-3627	663
NR1H2	3254	-1471
NR1H3	-1011	-2305
NR1I2	-1260	-4903
NR2C1	-3442	-1463
NR2C2	-2948	119
NR2C2AP	-4284	-4688
NR3C1	190	-2420
NR3C2	-3730	324
NR4A1	-2135	657
NR4A2	-494	1416
NR4A3	-1560	954
NR6A1	3935	-5344
NRBP1	917	-1365
NUDT21	-1105	13
PABPN1	-170	-3743
PAF1	1195	-5838
PAPOLA	3102	775
PARP1	-4461	-5521
PBRM1	2194	2290
PCBP4	-4148	-1359
PCGF5	-1005	-3951
PCGF6	-224	-3963
PCNA	-1864	-511
PDPK1	2505	167
PHAX	-1618	694
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
PHF20	-566	904
PIDD1	-2068	-6641
PIN1	-972	-1656
PINK1	4169	-3597
PIP4K2A	-691	1772
PIP4K2B	-2536	-6347
PIP4K2C	-4341	-5573
PLAGL1	145	1666
PLK2	-832	-6257
PLK3	2816	1597
PMAIP1	-4153	-2202
PML	-3036	549
PMS2	-1709	1574
POLDIP3	3177	-5416
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POU2F1	497	733
POU2F2	1502	950
PPARD	-1877	660
PPARGC1B	-1554	1840
PPM1A	3733	-3764
PPM1D	3473	-4316
PPP1R13B	-4370	1874
PPP1R13L	131	328
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5C	-4356	2376
PRDM1	-3050	799
PRDX1	3015	-877
PRDX2	1172	-5158
PRDX5	3911	-1661
PRKAA1	417	227
PRKAB1	405	-3297
PRKAB2	-2683	-1428
PRKACA	4377	-6032
PRKAG1	2166	-5980
PRKAG2	612	-5033
PRKCB	2983	-4518
PRKCQ	-4731	1372
PRMT1	-3038	-740
PRMT5	1213	-2112
PRR5	-4670	-1591
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTEN	3857	-1100
PTPN1	2276	2074
PTPN11	2065	-2302
PTPN4	-4781	-3156
RABGGTA	-728	1696
RABGGTB	-1598	2306
RAD1	-4779	1965
RAD17	-3691	-1101
RAD50	-2424	2067
RAD51	-816	-696
RAD51D	-4255	-710
RAD9A	-4403	-403
RAD9B	1007	-6145
RARA	2591	-5249
RARG	-1454	-5402
RB1	3934	-4740
RBBP4	-573	-3282
RBBP5	325	-779
RBBP8	-1410	-5854
RBL1	-3634	-3466
RBL2	-2338	-4497
RBM14	-2433	398
RBPJ	3993	-1118
RBX1	1413	-3241
RELA	-541	2085
RFC2	1890	-1206
RFC3	-3845	-803
RFC4	-3843	624
RFC5	-4565	-4946
RFFL	-521	-5968
RGCC	-2438	2408
RHEB	3346	-2334
RHNO1	-2040	-2816
RICTOR	-3355	1651
RING1	-1202	-1490
RMI2	-1205	1934
RNF111	2287	779
RNF2	1210	-1936
RNF34	-1908	42
RNGTT	976	-2952
RNMT	-4236	2172
RNPS1	-4416	-3160
RORA	-4632	2287
RPA1	-4680	-2495
RPA3	-3097	-1890
RPAP2	-3122	-3782
RPRD1A	1691	-3000
RPRD2	-1363	-2123
RPS27A	-2186	-2138
RPTOR	-3833	2134
RRAGA	2580	-1657
RRAGC	1887	-2585
RRAGD	4056	-6311
RRM2	-61	-574
RRM2B	2862	-5757
RTF1	1224	-4613
RUNX1	3296	-4082
RUNX2	-4261	-5055
RUNX3	-4877	2402
RYBP	2169	1520
SATB2	2725	-6456
SCMH1	-1695	1397
SCO1	-3488	-1715
SCO2	-1280	-4657
SESN1	-3131	-3887
SESN2	1227	-3423
SESN3	-1062	1141
SETD1A	-1735	-2070
SETD1B	237	-5034
SETD9	-385	-6605
SFN	478	-5994
SGK1	1695	-6076
SIN3A	-3920	-4151
SIN3B	-1249	570
SIRT1	-1251	-1775
SIRT3	-3023	-1430
SKI	-4099	-2431
SKIL	-194	-3633
SKP1	1561	-2290
SKP2	-2780	-1566
SLBP	2074	-327
SLC2A3	4226	-4757
SLC38A9	920	-3360
SLU7	887	-3467
SMAD1	3832	-3272
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMAD6	3462	-3209
SMAD7	-4655	-4450
SMARCA2	-808	296
SMARCA4	1769	2317
SMARCB1	-1149	-714
SMARCC1	-3109	1327
SMARCC2	-1239	-3828
SMARCD1	-4492	-2643
SMARCD2	2939	967
SMARCE1	-1297	-3418
SMURF1	-771	1321
SMURF2	-3700	-3048
SMYD2	-3637	-3757
SNAPC1	211	343
SNAPC2	1910	-3914
SNAPC3	-2873	-4100
SNAPC4	-267	-6719
SNAPC5	-1137	1443
SNRPB	-721	-2182
SNRPD3	498	1486
SNRPE	196	-919
SNRPG	504	-4002
SNW1	2003	946
SOCS3	4414	2178
SOCS4	-1486	-1919
SOD2	1617	573
SP1	3746	-3141
SPI1	4090	-6766
SRC	-3100	-4427
SREBF1	2743	-4015
SRRM1	-1550	-2963
SRRT	-1551	-3758
SRSF11	-3620	-5151
SRSF2	-1769	2284
SRSF3	-698	-121
SRSF4	1305	-2328
SRSF7	-2857	2075
SRSF9	3262	-3686
SSRP1	-4239	-2441
SSU72	1232	-4327
STAT1	-4575	2195
STK11	709	-5709
STUB1	-337	-2168
SUMO1	2937	-3986
SUPT16H	-4379	-3702
SUPT4H1	966	-1899
SUPT5H	-2124	-3641
SUPT6H	-1997	285
SURF1	1217	-4976
SYMPK	-1926	-2815
TACO1	1620	-5534
TAF10	3073	1606
TAF11	-873	-719
TAF12	3604	-1765
TAF13	3147	-908
TAF15	-2044	-3109
TAF2	-1849	-4149
TAF3	-546	-3002
TAF4	-518	-6161
TAF4B	-2590	-1647
TAF5	-1331	1150
TAF6	-2393	1804
TAF7	625	-3426
TAF8	1243	342
TAF9	390	1714
TBL1XR1	1687	962
TCEA1	-301	-4211
TCF12	-384	-4702
TCF3	-2132	-6049
TCF7	-3405	2023
TCF7L2	-1653	-3431
TFAP2E	-1971	-6087
TFDP1	3847	-1587
TFDP2	-4878	-4793
TGFA	4154	-3020
TGFB1	1971	-6
TGIF1	-2942	-5815
TGIF2	-3529	-6609
THOC1	-3697	73
THOC5	3155	747
THOC7	2604	-369
THRA	-1980	-2798
TIGAR	2559	-1893
TMEM219	1341	-6062
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFRSF10D	4239	-5911
TNKS1BP1	-1659	-5457
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TOP3A	3499	-3594
TOPBP1	-1032	180
TP53	-4078	-739
TP53BP2	2173	-5830
TP53I3	4166	-6077
TP53INP1	2698	-2058
TP53RK	-4658	-2342
TPX2	574	-4637
TRIAP1	72	-3808
TRIM28	-1482	1191
TRIM33	-3064	-2091
TSC1	-627	1527
TSC2	-257	895
TTC5	-774	-1440
TXN	3798	284
TXNIP	-3453	-2777
TXNRD1	3738	-4647
U2AF1	284	-5640
U2AF1L4	-1298	2171
U2AF2	1235	-306
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2I	-239	233
UBE2S	1785	2449
USP7	2617	-2216
VDR	3712	-3651
VEGFA	3184	-2723
WDR33	-2475	-3224
WDR5	39	-5613
WDR61	28	-4752
WRN	-4674	-2102
WWOX	-4198	1732
WWP1	-3587	-1865
YAF2	-2380	-3920
YEATS4	-1172	1953
YES1	-4790	-4415
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541
YY1	169	-5165
ZC3H8	-3638	-3807
ZFHX3	3232	-2025
ZFP1	-3907	-2240
ZFP14	-3631	1678
ZFP28	-2053	-6320
ZFP30	-4165	-366
ZFP37	-2723	-5928
ZFP90	-3403	824
ZFPM1	-3772	2378
ZIK1	-3912	2035
ZKSCAN1	694	-3843
ZKSCAN3	-2661	-5530
ZKSCAN4	-1583	-5770
ZKSCAN5	434	468
ZKSCAN8	-4216	-6728
ZNF10	-3834	-1897
ZNF101	-1720	2155
ZNF136	-4372	-3471
ZNF138	-4313	-5255
ZNF14	-4131	-4397
ZNF140	-2965	-2581
ZNF141	-2962	-526
ZNF143	3169	-418
ZNF155	-1519	-4127
ZNF160	-3165	-2923
ZNF169	-1862	-737
ZNF17	-3089	-1485
ZNF175	-2538	-5289
ZNF18	-758	-3535
ZNF180	-3963	-2110
ZNF184	-4192	-1046
ZNF189	1203	2001
ZNF19	-4170	907
ZNF2	-2476	-5367
ZNF20	1786	-4807
ZNF200	-55	-1750
ZNF202	-4126	1338
ZNF211	-4244	-6023
ZNF212	-3669	620
ZNF213	2401	-1128
ZNF215	-1151	-2720
ZNF221	-910	-6268
ZNF222	-24	-1983
ZNF223	-2119	-6465
ZNF224	-3564	-2768
ZNF226	-4044	-3429
ZNF227	-3395	-1334
ZNF23	-3824	-3592
ZNF233	-1195	-4234
ZNF234	-2816	-5598
ZNF235	-4279	-5194
ZNF248	-3871	-3321
ZNF25	-1661	-5487
ZNF250	-4613	554
ZNF253	-3828	-1053
ZNF257	-4014	-3813
ZNF26	-3624	-3960
ZNF264	-2454	-4068
ZNF268	-2207	-5808
ZNF274	-2742	-5798
ZNF282	1882	-5468
ZNF286A	-4478	-2915
ZNF287	-4733	-5090
ZNF3	-4753	-1141
ZNF302	-3817	659
ZNF311	-3622	-5855
ZNF324	-3334	-3484
ZNF324B	-4184	651
ZNF331	-2879	-2081
ZNF333	1412	-2425
ZNF337	-4391	-3809
ZNF33A	-2120	157
ZNF33B	-4558	-2030
ZNF34	-1698	-964
ZNF343	-4107	-4524
ZNF354A	1356	-4473
ZNF354C	-4069	-6378
ZNF382	-2280	-4717
ZNF394	411	-628
ZNF398	-1818	155
ZNF417	-1502	-2829
ZNF418	-2180	-6578
ZNF419	-4137	-5268
ZNF420	-3590	-3752
ZNF425	-2227	-4710
ZNF426	-1324	-3104
ZNF43	-4605	-5370
ZNF430	-1473	-4879
ZNF431	-3388	-5647
ZNF432	-4169	-5374
ZNF436	-3361	-5576
ZNF440	-3011	-5938
ZNF443	-1568	-4894
ZNF445	1126	-5606
ZNF446	-3726	-3030
ZNF461	-4647	-2540
ZNF468	-513	-4348
ZNF470	-3286	-6469
ZNF480	-1990	-4983
ZNF483	-3446	-5903
ZNF484	-3315	-304
ZNF490	-783	-2501
ZNF492	-1393	-6580
ZNF496	-4447	-3057
ZNF500	-4498	1026
ZNF506	-3256	-4344
ZNF517	-4363	-228
ZNF528	-4094	-6459
ZNF529	-3695	-3659
ZNF530	-4642	-6175
ZNF540	-3904	-4576
ZNF546	-1436	-1610
ZNF547	-1574	-4822
ZNF549	-4440	-5587
ZNF550	-4036	-5905
ZNF552	1731	-5023
ZNF554	-4534	-1275
ZNF559	-2885	-4261
ZNF561	-1293	-2945
ZNF563	-3812	-5992
ZNF564	-1352	-2468
ZNF566	-4275	-939
ZNF567	-2995	-5136
ZNF568	-4424	-6314
ZNF569	-4362	-352
ZNF570	-4449	-4872
ZNF571	-4516	-5324
ZNF573	-3242	-3023
ZNF582	-3192	-6112
ZNF583	-3431	-4848
ZNF584	-4271	-5742
ZNF585A	-2466	-4862
ZNF585B	-3890	-2710
ZNF587	-59	-1759
ZNF589	-1637	1425
ZNF596	-3558	-6669
ZNF597	-3297	-4633
ZNF600	-4299	-5453
ZNF605	-747	-1335
ZNF606	-3055	-5401
ZNF610	-1917	-6042
ZNF611	-1426	-5441
ZNF613	611	-5448
ZNF614	-3255	-2566
ZNF615	-1597	-5583
ZNF619	-3039	-6317
ZNF620	-4587	-5485
ZNF621	-4196	-3523
ZNF624	-988	-3879
ZNF627	-326	-2790
ZNF641	-2657	-5851
ZNF655	-1022	-2976
ZNF664	-3436	1571
ZNF665	-2685	-6565
ZNF668	1280	1462
ZNF670	-875	-5736
ZNF671	-2463	-680
ZNF677	-3095	-6476
ZNF678	-4128	530
ZNF681	-2855	-3353
ZNF684	-3449	-2033
ZNF688	-2649	-4023
ZNF689	-3441	-4943
ZNF691	-1949	-4147
ZNF692	-1263	-1190
ZNF696	-4484	-3058
ZNF70	-4592	-5340
ZNF700	-1440	-3707
ZNF701	-1066	-6116
ZNF703	-4175	-4320
ZNF706	-1898	-5848
ZNF707	-4438	-4401
ZNF708	-3383	-2881
ZNF709	-2918	-6445
ZNF710	2910	-6541
ZNF713	-1737	-3012
ZNF714	-987	-2480
ZNF717	-2959	-5768
ZNF736	-4428	-4463
ZNF737	-3430	-6022
ZNF74	-4652	-2918
ZNF740	-4237	878
ZNF746	3354	-3816
ZNF747	1378	-451
ZNF749	-3645	-5865
ZNF75A	-2479	-1824
ZNF761	-1712	-3885
ZNF764	-2086	-913
ZNF77	-4172	-489
ZNF771	-2367	-3926
ZNF772	-736	-5966
ZNF774	1748	-1078
ZNF775	1932	-4991
ZNF776	112	-3870
ZNF777	-2261	-4823
ZNF778	-3841	1050
ZNF782	-3133	128
ZNF785	-2212	-5042
ZNF786	-2209	56
ZNF79	-3042	470
ZNF790	-3830	-6139
ZNF791	-2511	-5116
ZNF792	-3010	645
ZNF793	-3296	-6557
ZNF799	-3658	-6025
ZNF839	-668	-6246
ZNF92	-3748	-2695
ZSCAN25	-3303	2482

---

---

Metabolism of RNA

Metabolism of RNA

metric	value
setSize	535
pMANOVA	6.45e-08
p.adjustMANOVA	2.67e-06
s.dist	0.154
s.RNA	-0.092
s.meth	0.123
p.RNA	0.000343
p.meth	1.72e-06

Top 20 genes

Gene	RNA	meth
NOP14	-4072	2384
RNMT	-4236	2172
WDR77	-3504	2308
UPF3A	-3597	2175
RRP9	-3599	2034
RPL3	-2866	2313
ADAT1	-3252	1883
RPL23A	-3305	1843
MTERF4	-3859	1559
SRSF7	-2857	2075
NUP43	-3356	1617
NOL9	-3678	1426
EXOSC2	-4042	1269
FUS	-2256	2205
RPL13A	-2702	1802
RPS11	-2281	2115
FAM98B	-2764	1741
TTC37	-2278	2107
SF3A3	-4061	1130
DDX5	-3458	1288

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ACTB	4172	-4515
ADAR	-1039	-263
ADARB1	-1471	-6225
ADAT1	-3252	1883
ADAT2	-3392	-2393
ADAT3	348	1001
AKT1	1248	-1942
ALKBH8	-4470	-3991
ALYREF	2121	-4902
ANP32A	3769	-3737
AQR	583	-336
BMS1	-4477	-2552
BUD31	3067	776
BYSL	-1313	-88
C1D	1236	510
C2orf49	-1773	-443
CASC3	2017	-2580
CCAR1	-709	-2951
CCNH	249	-3754
CD2BP2	-642	-6240
CD44	3745	266
CDC40	2856	2242
CDC5L	2334	-5959
CDK7	2020	275
CDKAL1	-3229	-2998
CHERP	-1533	-2459
CLNS1A	376	-1163
CLP1	2775	-1417
CNOT1	-1283	-4543
CNOT10	-800	-361
CNOT11	661	-2236
CNOT3	2060	565
CNOT4	-392	-3064
CNOT6	1776	-3728
CNOT6L	-4344	-5686
CNOT7	-1157	349
CNOT8	3743	-2054
CPSF1	-1130	-6284
CPSF2	3479	-3164
CPSF3	2696	-4860
CPSF4	-3362	134
CRNKL1	1533	433
CSNK1D	771	-1777
CSNK1E	-3694	-4750
CSTF1	-1905	2021
CTNNBL1	540	-2232
CTU1	1703	-3154
CTU2	-3002	-2262
CWC15	-720	-4721
CWC22	271	-3308
CWC27	1649	2224
DCAF13	-1724	-2001
DCP1A	-1678	-2482
DCP1B	-4522	-5406
DCP2	2839	-2783
DCPS	-730	-1076
DDX1	-844	-558
DDX20	-3990	-3695
DDX21	1019	760
DDX23	-230	164
DDX42	4	-1996
DDX46	830	-2306
DDX47	-4203	-3056
DDX49	1837	-4408
DDX5	-3458	1288
DDX52	161	-1954
DDX6	-581	1106
DHX16	-1493	-3824
DHX37	-2778	-312
DHX9	317	871
DIS3	-1302	-762
DNAJC8	369	605
DUS2	1189	2247
EBNA1BP2	-1242	1600
EDC3	1269	-1960
EDC4	-1531	-5349
EFTUD2	3727	1095
EIF4A1	3272	-3762
EIF4A2	-4065	836
EIF4A3	3171	-3850
EIF4B	387	-4336
EIF4E	1815	1536
EIF4G1	3607	746
ELAC2	-4602	-916
ELAVL1	643	-6154
ENPP2	627	-2276
ERCC2	1202	-594
ERCC3	-2537	969
ERI1	2175	130
ETF1	3196	758
EXOSC1	-309	-290
EXOSC10	-4357	-1580
EXOSC2	-4042	1269
EXOSC3	153	-2555
EXOSC4	3412	-4410
EXOSC5	-1316	1591
EXOSC6	-3569	545
EXOSC7	-3984	-4665
EXOSC8	-4307	1020
FAM98B	-2764	1741
FAU	-129	-3862
FBL	-3630	-2611
FCF1	1658	-2675
FIP1L1	-2679	-2274
FTSJ3	-1175	-670
FUS	-2256	2205
FYTTD1	-1788	1459
GAR1	-2237	-4416
GCFC2	-3957	-2094
GEMIN2	-2571	-3548
GEMIN4	-3973	-6519
GEMIN5	-1573	-2833
GEMIN6	754	-1619
GEMIN7	1793	1324
GLE1	1976	829
GNL3	-2812	-1419
GSPT1	2706	-4456
GTF2F1	1892	-1723
GTF2F2	2127	-2885
GTF2H3	-664	1025
GTF2H4	-874	-2761
GTF2H5	1343	691
GTPBP3	-2331	-3838
HBS1L	1903	-598
HEATR1	-3704	-1985
HNRNPA0	-2990	460
HNRNPA2B1	1139	-2665
HNRNPC	2584	-1112
HNRNPD	912	-1374
HNRNPF	1377	-58
HNRNPH1	-2572	-1020
HNRNPK	3313	-2386
HNRNPL	-20	-741
HNRNPM	2005	-4945
HNRNPR	-2901	-4296
HNRNPU	938	-970
HNRNPUL1	960	-1966
HSPA1A	3666	-3825
HSPB1	544	-4137
IGF2BP3	2519	-4480
IMP3	-3221	99
IMP4	-3938	-2925
ISG20L2	1327	1893
ISY1	2310	-4700
KHSRP	873	-5005
KRR1	-2919	-6562
LCMT2	-3688	-441
LSM1	2529	515
LSM10	2631	-3871
LSM11	-3703	-4172
LSM2	840	-1678
LSM3	-123	-674
LSM4	-3913	-5491
LSM5	-1969	-3381
LSM6	3106	-1989
LSM7	-2032	-5454
LSM8	-3337	-2296
LTV1	-1261	-3205
MAPK14	4264	-3529
MAPKAPK2	1470	2012
METTL1	-2158	-5208
METTL14	-2336	-4236
MNAT1	-3019	311
MPHOSPH10	-2599	-57
MPHOSPH6	711	-5463
MRM1	-3331	-5990
MTERF4	-3859	1559
MTO1	-2863	-856
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCL	-3268	-2515
NDC1	-4771	-5228
NHP2	-1035	-260
NIP7	-1832	-1760
NOB1	-3760	-1000
NOC4L	-1679	1990
NOL11	-3686	-2629
NOL12	1849	505
NOL6	-4033	526
NOL9	-3678	1426
NOP10	3831	-3526
NOP14	-4072	2384
NOP2	-3314	-2438
NOP56	-4412	-523
NOP58	-3586	-2406
NSUN2	-564	65
NSUN4	-1455	-3469
NSUN6	-2372	-2844
NUDT21	-1105	13
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
NXF1	576	-162
NXT1	-2486	1069
PABPC1	2073	-2769
PABPN1	-170	-3743
PAIP1	941	241
PAN2	-1213	-1449
PAN3	3	-3562
PAPOLA	3102	775
PARN	-1590	-4138
PATL1	2040	-5336
PCBP1	3345	-1395
PCBP2	2042	132
PDCD11	-4437	-2174
PDCD7	-2467	-1270
PELP1	-4029	-1579
PES1	-604	-3908
PHAX	-1618	694
PLRG1	-2123	692
PNO1	-2216	-5495
PNRC2	-1380	-2821
POLDIP3	3177	-5416
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POM121	-2762	-1787
POM121C	-2356	-4315
POP1	-1219	-517
POP4	-1127	2076
POP5	-3228	-4690
POP7	1489	466
PPIE	-2980	644
PPIH	-4426	-2541
PPIL1	-1715	-5540
PPIL3	-1555	-1459
PPIL4	1017	-2414
PPIL6	86	1558
PPP2CA	3740	300
PPP2R2A	1485	-5074
PPWD1	-3800	513
PRCC	801	-2557
PRKCA	368	810
PRKCD	4146	584
PRMT5	1213	-2112
PRPF19	-3052	-2289
PRPF3	-2410	-5317
PRPF31	-2459	-4737
PRPF38A	-74	-2763
PRPF40A	891	2454
PRPF6	-2300	-2317
PRPF8	-2712	-1872
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTBP1	-64	-1843
PUF60	-274	1796
PUS1	-1871	-1746
PUS3	1252	-5241
PUS7	-1605	263
PWP2	-312	681
QTRT1	-3156	-3239
RAE1	1948	-39
RAN	-2179	1257
RANBP2	-259	-4704
RBM17	-1497	1681
RBM28	-4525	-685
RCL1	-272	-1421
RIOK1	-1124	-2098
RIOK2	305	-954
RIOK3	4000	-2443
RNGTT	976	-2952
RNMT	-4236	2172
RNPC3	-1284	-1410
RNPS1	-4416	-3160
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPP14	1011	-354
RPP21	-1592	-5256
RPP25	-2803	-5917
RPP30	-2733	-5522
RPP38	-2173	1598
RPP40	-1422	-1426
RPPH1	557	-5149
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRP1	-936	77
RRP7A	-853	-2961
RRP9	-3599	2034
RTCB	-407	-261
SART1	1286	218
SEC13	2286	-3749
SEH1L	-1833	-1615
SENP3	975	-1248
SET	-2265	-5937
SF1	-198	-1708
SF3A1	-734	-2997
SF3A2	-1624	2430
SF3A3	-4061	1130
SF3B2	588	-3350
SF3B3	-3537	-1675
SF3B4	727	984
SF3B5	1089	-4116
SKIV2L	-1019	-2116
SLBP	2074	-327
SLU7	887	-3467
SMG1	-1318	-3377
SMG5	2055	-4423
SMG6	-1965	1909
SMG7	2780	-589
SMG8	943	-3537
SMNDC1	2225	-3187
SNRNP200	-4144	-2478
SNRNP25	-91	2102
SNRNP27	2727	1474
SNRNP35	1699	-3130
SNRNP40	-3814	-1247
SNRNP48	-380	996
SNRNP70	-1924	-371
SNRPA	788	1121
SNRPA1	-3646	-3336
SNRPB	-721	-2182
SNRPB2	1086	-5774
SNRPC	222	-3668
SNRPD1	207	-1771
SNRPD2	-2542	1134
SNRPD3	498	1486
SNRPE	196	-919
SNRPG	504	-4002
SNRPN	-3451	-5234
SNU13	-2197	1961
SNUPN	2477	-2979
SNW1	2003	946
SRRM1	-1550	-2963
SRRM2	-814	2142
SRRT	-1551	-3758
SRSF10	-2707	1198
SRSF11	-3620	-5151
SRSF2	-1769	2284
SRSF3	-698	-121
SRSF4	1305	-2328
SRSF7	-2857	2075
SRSF9	3262	-3686
SUPT5H	-2124	-3641
SYF2	1904	-1707
SYMPK	-1926	-2815
TBL3	-1028	994
TEX10	-3484	-1947
TFB1M	-4339	-3739
TFIP11	137	-278
THADA	-4579	-3826
THG1L	-3944	-2349
THOC1	-3697	73
THOC5	3155	747
THOC7	2604	-369
THUMPD1	-3487	-4292
TNFSF13	3753	-5904
TNKS1BP1	-1659	-5457
TNPO1	1443	-1546
TP53RK	-4658	-2342
TPR	-2272	-973
TPRKB	-1589	-2506
TRDMT1	295	-4357
TRIT1	244	-2615
TRMT1	-909	1178
TRMT10A	2917	-5299
TRMT11	-4074	-4066
TRMT112	184	-4666
TRMT12	-128	956
TRMT44	-2070	-1269
TRMT6	2306	1951
TRMT61A	-3309	-4239
TRMT61B	-2646	-2862
TRMU	-3167	-1879
TRNT1	-2488	-1006
TSEN15	-3616	-3075
TSEN2	-4098	-3251
TSEN34	3312	-751
TSEN54	-4822	-550
TSR1	-3373	-3041
TSR3	1352	1167
TTC37	-2278	2107
TXNL4A	2977	-1664
TYW1	-3213	-820
TYW3	-2744	-4913
TYW5	-375	485
U2AF1	284	-5640
U2AF1L4	-1298	2171
U2AF2	1235	-306
U2SURP	-1963	-4877
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UPF1	1742	-630
UPF2	319	-1572
UPF3A	-3597	2175
URM1	-373	-3584
USP39	1460	117
UTP15	-3865	-2796
UTP18	1954	-3819
UTP20	-3801	-1372
UTP3	-883	-3665
UTP6	-1353	-1904
WBP11	-4554	-1693
WBP4	2103	-3514
WDR12	2015	706
WDR18	-707	-2042
WDR3	-2064	-5710
WDR33	-2475	-3224
WDR36	-1144	-2277
WDR43	-2465	-4225
WDR61	28	-4752
WDR75	-3459	1028
WDR77	-3504	2308
WTAP	1569	-525
XAB2	-575	-1877
XPO1	-371	-870
XPOT	-810	-828
XRN1	-2198	-5555
XRN2	4368	-5589
YBX1	1033	-364
YWHAB	2609	2125
YWHAZ	2220	541
ZBTB8OS	1538	-1338
ZCRB1	219	2291
ZFP36	2973	1924
ZFP36L1	2915	784
ZMAT5	2803	-6365

---

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

metric	value
setSize	110
pMANOVA	7.14e-08
p.adjustMANOVA	2.86e-06
s.dist	0.33
s.RNA	-0.225
s.meth	0.242
p.RNA	4.76e-05
p.meth	1.27e-05

Top 20 genes

Gene	RNA	meth
IPO5	-3937	1869
RPL3	-2866	2313
RPL23A	-3305	1843
NUP43	-3356	1617
RPL13A	-2702	1802
RPS11	-2281	2115
RPL32	-2060	1928
NUP210	-3968	910
NUP205	-4259	826
RPS2	-1347	2392
NUP160	-3773	763
RPL35	-2748	952
RPL4	-1061	2321
RPS10	-1744	1246
RPS15	-1096	1808
RPS15A	-1748	1086
RPL17	-1666	1099
RPS3A	-1414	1275
POLR2H	-849	1944
NUP153	-1967	834

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
DNAJC3	3833	-2353
FAU	-129	-3862
GRSF1	1991	27
GTF2F1	1892	-1723
GTF2F2	2127	-2885
HSP90AA1	415	-781
IPO5	-3937	1869
NDC1	-4771	-5228
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
PARP1	-4461	-5521
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POM121	-2762	-1787
POM121C	-2356	-4315
RAE1	1948	-39
RANBP2	-259	-4704
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
SEC13	2286	-3749
SEH1L	-1833	-1615
TPR	-2272	-973
UBA52	344	752

---

---

Cellular responses to stress

Cellular responses to stress

metric	value
setSize	392
pMANOVA	7.67e-08
p.adjustMANOVA	2.96e-06
s.dist	0.163
s.RNA	0.116
s.meth	0.114
p.RNA	9.27e-05
p.meth	0.000123

Top 20 genes

Gene	RNA	meth
MAP4K4	3853	2014
PHC2	4201	1830
DNAJB6	3591	1923
ATP6V1A	4307	1580
ATP6V0B	3961	1604
LAMTOR2	3365	1882
BAG1	2645	2301
MAPK1	3257	1865
PSMA7	3060	1752
FOS	2486	2149
PSMD1	3121	1660
CBX8	2136	2207
AGO1	2205	1997
UBE2S	1785	2449
PRDX3	4355	972
PSME3	3757	1116
ARNT	3603	1140
DNAJA2	2208	1824
NUP214	3562	1119
EIF2AK1	3869	1012

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ACD	-2500	-5810
ACTR10	3334	-1291
ACTR1A	3003	-1
AGO1	2205	1997
AGO3	-318	-6442
AJUBA	-2581	-2301
AKT1S1	3491	-2319
ANAPC1	-4630	403
ANAPC10	-1544	-6111
ANAPC11	2526	344
ANAPC15	4157	-1379
ANAPC16	-645	-4507
ANAPC2	-2344	-1007
ANAPC4	-2143	-1696
ANAPC5	-4174	-2530
ANAPC7	-1607	1560
ARNT	3603	1140
ASNS	-2777	12
ATF3	-3533	-4121
ATF4	2565	-956
ATF5	-1651	-722
ATM	-4028	202
ATOX1	1607	-5343
ATP6V0B	3961	1604
ATP6V0C	4207	-4697
ATP6V0D1	4304	-1003
ATP6V0E1	3941	-2865
ATP6V0E2	-4392	-6625
ATP6V1A	4307	1580
ATP6V1B2	4141	-4232
ATP6V1C1	3922	655
ATP6V1D	4210	-1234
ATP6V1E1	3620	-3948
ATP6V1F	2354	1350
ATP6V1G2	-3209	-3714
ATP6V1H	3629	-1695
ATR	-3783	970
BAG1	2645	2301
BAG2	-2453	-2208
BAG3	-948	423
BAG4	3782	-3089
BAG5	-1485	-4477
BMI1	-3450	-6383
C12orf66	-4090	-3658
CABIN1	-3797	-2517
CAMK2D	-4549	-2867
CAMK2G	598	2354
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CAT	4221	-3922
CBX4	706	-5288
CBX6	1438	-3511
CBX8	2136	2207
CCAR2	-3702	2391
CCNA2	521	-1132
CCNE1	-4509	-3403
CCNE2	1961	-3396
CCS	423	102
CDC16	-1863	-4152
CDC23	-4319	-707
CDK2	-1524	1018
CDK4	-4195	-1295
CDK6	-1983	-2864
CDKN1A	1606	-3540
CDKN1B	-2779	-862
CDKN2A	-1623	-4511
CDKN2C	2963	-130
CDKN2D	3554	308
CEBPB	3621	-5089
CEBPG	2149	1702
CITED2	2650	-104
CREBBP	1169	-5804
CUL2	821	-1212
CYBA	2925	1006
CYCS	-386	-3927
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DDIT3	1835	-3177
DEDD2	1115	1927
DEPDC5	37	-4322
DNAJA1	2118	-1834
DNAJA2	2208	1824
DNAJA4	-281	2305
DNAJB1	-1723	-3687
DNAJB6	3591	1923
DNAJC2	-1518	-1772
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
E2F1	2654	-1005
E2F2	4026	386
E2F3	2805	-2884
EED	-3277	-1174
EEF1A1	-1543	720
EGLN1	2782	-6231
EGLN2	1184	-3619
EHMT1	-2969	-1697
EHMT2	-2882	-1059
EIF2AK1	3869	1012
EIF2AK4	45	-5466
EIF2S1	1555	-4266
EIF2S2	2502	-783
EP300	2504	-4509
EP400	-2035	1434
EPAS1	3555	535
ERF	1596	-683
ERO1A	4059	-4535
ETS1	-4302	2277
ETS2	3572	-5483
EZH2	-3517	-20
FAU	-129	-3862
FKBP4	253	-4442
FKBP5	4105	-5653
FLCN	1241	708
FNIP1	2212	355
FOS	2486	2149
FZR1	-666	-758
GCN1	-3719	-6714
GPX1	4356	-5467
GRB10	4408	-70
GSK3B	2793	736
GSR	4279	-4724
GSTP1	62	-5415
HIF1A	3192	-3349
HIF1AN	-1365	-1051
HIGD1A	3226	-4744
HIRA	-3473	-860
HMGA1	24	802
HSBP1	3667	-3338
HSF1	2462	1452
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
HSPA13	-355	-1732
HSPA14	-3352	866
HSPA1A	3666	-3825
HSPA1B	2667	-513
HSPA1L	1008	885
HSPA2	3087	-271
HSPA4	2078	963
HSPA4L	-696	-5898
HSPA9	-3551	-200
HSPH1	-3193	993
ID1	1788	-3980
ITFG2	-3941	-873
JUN	1372	69
KAT5	419	-650
KDM6B	3966	-92
KPTN	2585	1279
LAMTOR1	4379	-5950
LAMTOR2	3365	1882
LAMTOR3	3357	321
LAMTOR4	1631	-6150
LAMTOR5	3910	-5095
LIMD1	-4087	-6080
LMNB1	4362	-942
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K5	3379	-4989
MAP4K4	3853	2014
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MDM2	1471	-1318
MDM4	-377	-2440
MINK1	1278	-4004
MIOS	1147	561
MLST8	98	287
MOV10	-4691	-6449
MRPL18	678	-1383
MTOR	-3531	-1813
NBN	710	750
NCF4	4349	-6732
NDC1	-4771	-5228
NPRL2	-4368	2371
NPRL3	1659	2138
NR3C1	190	-2420
NR3C2	-3730	324
NUDT2	1000	-2046
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
P4HB	3824	-1549
PHC1	-2566	-5180
PHC2	4201	1830
PHC3	-2711	1805
POM121	-2762	-1787
POM121C	-2356	-4315
PPP1R15A	2403	-5399
PRDX1	3015	-877
PRDX2	1172	-5158
PRDX3	4355	972
PRDX5	3911	-1661
PRDX6	4128	916
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTGES3	1472	-1810
RAD50	-2424	2067
RAE1	1948	-39
RANBP2	-259	-4704
RB1	3934	-4740
RBBP4	-573	-3282
RBX1	1413	-3241
RELA	-541	2085
RHEB	3346	-2334
RING1	-1202	-1490
RNF2	1210	-1936
RPA1	-4680	-2495
RPA3	-3097	-1890
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS19BP1	869	436
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RPTOR	-3833	2134
RRAGA	2580	-1657
RRAGC	1887	-2585
RRAGD	4056	-6311
SCMH1	-1695	1397
SEC13	2286	-3749
SEH1L	-1833	-1615
SERPINH1	-3655	-1891
SESN1	-3131	-3887
SESN2	1227	-3423
SIRT1	-1251	-1775
SLC38A9	920	-3360
SOD1	-1490	-1019
SOD2	1617	573
SP1	3746	-3141
ST13	-391	-5101
STAT3	3649	-3606
STIP1	-648	31
SZT2	-1603	-5754
TCIRG1	3114	-5082
TERF1	-1048	-1932
TERF2	-1349	982
TERF2IP	1931	-4579
TFDP1	3847	-1587
TFDP2	-4878	-4793
TINF2	1711	-1513
TNIK	-4483	-2132
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TP53	-4078	-739
TPR	-2272	-973
TRIB3	-1812	1669
TXN	3798	284
TXN2	1737	-257
TXNRD1	3738	-4647
TXNRD2	3275	-5499
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2C	1959	1091
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2E1	2865	-5882
UBE2S	1785	2449
UBN1	2080	-3899
VCP	2927	-2411
VEGFA	3184	-2723
VHL	1285	1389
WDR24	359	-6152
WDR59	-3112	-1721
YWHAE	4144	-4168

---

---

Metabolism of lipids

Metabolism of lipids

metric	value
setSize	427
pMANOVA	1.01e-07
p.adjustMANOVA	3.79e-06
s.dist	0.162
s.RNA	0.162
s.meth	-0.00959
p.RNA	1.4e-08
p.meth	0.737

Top 20 genes

Gene	RNA	meth
GGT1	4400	-6607
TSPO	4360	-6553
PTGR1	4198	-6711
ARF1	4190	-6686
TBXAS1	3948	-6709
PRKACA	4377	-6032
PLD1	4274	-6058
ALOX5	4195	-6082
ALOX5AP	3592	-6710
CHPT1	4069	-5900
GPX1	4356	-5467
PGS1	4009	-5906
PNPLA2	4155	-5698
VAPA	4183	-5592
GBA	4159	-5623
PLB1	4419	-5279
HEXB	3996	-5777
FIG4	4184	-5382
HSD17B4	4070	-5528
GLTP	3827	-5867

Click HERE to show all gene set members

All member genes

	RNA	meth
AACS	107	843
ABCA1	2422	-6487
ABCC1	187	-871
ABHD3	2978	-4046
ABHD4	2681	-5841
ABHD5	3483	-5560
ACAA1	3791	1410
ACACA	2069	-164
ACACB	-3479	-4884
ACAD10	1812	-83
ACAD11	-3735	-2327
ACADM	-393	-2163
ACADS	1571	-6188
ACAT1	2162	-2579
ACAT2	-1087	-2151
ACBD4	-1304	-2973
ACBD5	-382	-2520
ACBD6	-4120	-1414
ACBD7	1110	-5886
ACER2	651	-2800
ACER3	4238	-1641
ACLY	1979	-5417
ACOT13	2120	-3113
ACOT7	-946	1021
ACOT8	3634	-2563
ACOX1	4116	-5075
ACOX3	2419	-4725
ACOXL	1787	2527
ACP6	-1140	-5222
ACSF2	-4350	-5644
ACSF3	-119	-5695
ACSL1	4329	-1604
ACSL3	3508	-4285
ACSL5	-3940	-215
ACSL6	-1755	2501
ACSM3	-2417	-6252
AGK	-4734	-3004
AGPAT1	3720	559
AGPAT2	4297	2250
AGPAT3	1685	-2039
AGPAT4	-2900	-4185
AGPAT5	-3437	221
AGPS	2085	-3742
AHR	3094	2099
AHRR	-1817	-702
AKR1B1	-4560	1845
ALDH3A2	286	-2186
ALOX5	4195	-6082
ALOX5AP	3592	-6710
AMACR	-2263	-663
ARF1	4190	-6686
ARF3	3423	-1912
ARNT	3603	1140
ARNTL	-2187	-4129
ARSA	1185	-3099
ARSB	3173	-5722
ARSG	-1451	152
ARSK	-4241	-54
ARV1	-812	-2677
ASAH1	3775	335
BDH1	-3796	-5778
BDH2	-4267	-6434
CAV1	584	-2432
CBR4	-381	-2264
CCNC	596	-1138
CDIPT	2558	-2467
CDK19	3360	-2575
CDK8	-597	-5509
CDS2	2757	979
CEPT1	360	289
CERK	-1619	1601
CERS5	-662	-6266
CERS6	2279	-3796
CHD9	-1356	-5791
CHKA	2438	-4562
CHKB	-966	816
CHPT1	4069	-5900
CLOCK	-2413	-1159
CPNE1	-1013	1274
CPNE3	2359	-2088
CPT1A	1949	-6398
CPT2	2687	-6494
CPTP	1273	-2096
CRAT	4114	-4890
CREBBP	1169	-5804
CRLS1	4214	-4654
CSNK1G2	289	-1639
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CTSA	4423	-4847
CYP2R1	-3592	-1915
CYP2U1	-4695	-4531
CYP46A1	-108	1529
CYP4F22	-4843	-2371
CYP51A1	2920	-5191
DBI	2593	441
DDHD1	-4445	1414
DDHD2	-4506	-2861
DECR1	2010	-528
DECR2	307	830
DEGS1	2545	-193
DGAT1	2058	-6115
DGAT2	4293	-1911
DHCR24	911	-5657
DHCR7	2895	-3544
DHRS7B	3291	-3549
DPEP2	-826	-6530
ECHS1	-683	-1673
ECI1	165	-4832
ECI2	-4595	-2127
EHHADH	2481	-6438
ELOVL1	3061	-1168
ELOVL4	-1775	-2987
ELOVL5	2426	-3408
ELOVL6	-4462	-1124
EP300	2504	-4509
EPHX2	-3486	-5989
ESRRA	2370	-2927
ESYT1	-4767	959
ESYT2	-4518	-1193
ETNK1	-430	1286
FABP5	2453	-3534
FADS1	3438	-4312
FADS2	512	-5605
FAM120B	-9	-2607
FAR1	3989	-224
FASN	-220	1100
FDFT1	3218	-4585
FDPS	2086	124
FDX1	607	-3747
FDXR	1779	-3448
FIG4	4184	-5382
FITM2	-1795	-2082
GALC	3838	264
GBA	4159	-5623
GBA2	973	-4419
GDE1	3933	-5040
GDPD1	-1379	-1268
GDPD5	-3901	-2713
GGPS1	-314	-2782
GGT1	4400	-6607
GLB1	3936	1368
GLIPR1	3427	-2351
GLTP	3827	-5867
GM2A	4138	-825
GPAM	-3559	-4630
GPCPD1	3801	-203
GPD1	-2210	-6250
GPD1L	-3917	-2487
GPD2	3273	-6521
GPS2	-290	-857
GPX1	4356	-5467
GPX4	1974	-455
GSTM4	386	-4359
HACD1	1663	-4245
HACD2	-520	1513
HACD3	-4003	2329
HACD4	2852	500
HACL1	-4577	-3683
HADH	-4304	-4809
HADHA	3987	1866
HADHB	4385	-968
HDAC3	1740	-3771
HEXA	397	-4273
HEXB	3996	-5777
HILPDA	-474	670
HMGCL	2061	1969
HMGCR	3683	-3388
HMGCS1	-599	-2608
HPGD	3383	-6446
HSD17B1	1246	1940
HSD17B11	3617	-3328
HSD17B12	3123	-895
HSD17B4	4070	-5528
HSD17B8	-3846	2077
IDI1	2830	1929
INPP4A	-3443	2209
INPP5D	-1183	-3735
INPP5E	-2503	2080
INPP5F	-1475	507
INPP5K	-603	1585
INPPL1	4209	-2224
INSIG1	-3875	947
INSIG2	2691	-4256
KPNB1	799	-2176
LBR	3693	-3506
LCLAT1	-65	-2733
LGMN	-1423	313
LIPE	-3073	-5437
LPCAT1	-2464	1540
LPCAT3	3956	-3100
LPCAT4	-2741	1628
LPGAT1	3889	-5760
LPIN1	-4324	-2651
LPIN2	-2222	2060
LSS	-3854	-4805
LTA4H	4306	-972
LTC4S	-116	-6617
MAPKAPK2	1470	2012
MBOAT1	2117	-4287
MBOAT7	3930	-3703
MBTPS1	951	-398
MCAT	2137	-3215
MCEE	-1431	320
MECR	-2375	350
MED1	-1217	-2271
MED10	-2937	-2572
MED11	-225	609
MED13	824	590
MED13L	2446	-533
MED15	-3549	2114
MED16	2032	1719
MED17	967	-1418
MED18	1632	-186
MED19	1088	-4664
MED20	2864	-542
MED21	-1738	-582
MED22	1282	-2059
MED23	-2103	633
MED24	-2416	-2701
MED25	2547	-1286
MED26	1615	18
MED27	-3240	-960
MED28	-424	699
MED29	-2664	-5128
MED30	-1688	491
MED31	456	445
MED4	1079	-4472
MED6	-284	560
MED7	55	778
MED8	3319	1289
MED9	-3072	-3399
MFSD2A	-677	-5062
MLYCD	-3448	97
MMAA	-4458	-3965
MORC2	-3116	2508
MSMO1	836	1922
MTF1	4099	-2992
MTMR10	3605	-3555
MTMR12	-489	-579
MTMR14	3552	-4278
MTMR2	-674	519
MTMR3	4203	-2340
MTMR4	962	-1420
MTMR6	3451	1477
MTMR9	458	-2578
MVD	-1820	1954
MVK	-2844	-2474
NCOA2	352	1407
NCOA3	1207	-2266
NCOA6	2298	-1860
NCOR1	2375	-3738
NCOR2	3521	-4281
NDUFAB1	2302	-395
NEU1	4191	-3878
NEU3	-1129	-1409
NFYA	1190	1464
NFYB	-3535	-531
NFYC	3381	-3078
NR1D1	-2922	1187
NR1H2	3254	-1471
NR1H3	-1011	-2305
NRF1	-2774	-4642
NUDT19	2689	1908
NUDT7	338	593
ORMDL1	-1848	-584
ORMDL3	-3560	-2716
OSBP	-795	-3696
OSBPL2	1964	-2911
OSBPL3	-4646	375
OSBPL5	-4813	-6730
OSBPL7	-4508	-4735
OSBPL8	2987	-2735
OSBPL9	2669	-2108
OXCT1	-4420	1553
PCCB	-2665	-6219
PCTP	4342	-3451
PCYT1A	2903	822
PCYT2	-4288	-2669
PECR	4063	2064
PEMT	1021	-4605
PEX11A	-3101	-2595
PGS1	4009	-5906
PHOSPHO1	954	-430
PI4K2A	-2091	-355
PI4K2B	-4718	-317
PI4KA	-785	-5
PI4KB	-1344	1292
PIAS4	1999	-3982
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3CG	646	-2045
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIK3R4	-1199	-3425
PIK3R5	-695	514
PIKFYVE	1060	-2382
PIP4K2A	-691	1772
PIP4K2B	-2536	-6347
PIP4K2C	-4341	-5573
PIP5K1A	2498	-348
PIP5K1C	1156	-5383
PISD	4147	-4659
PITPNB	-2282	-4909
PITPNM1	2303	873
PITPNM2	-1470	2520
PITPNM3	-1010	1888
PLA2G12A	2266	-5029
PLA2G15	4049	-3722
PLA2G4C	-846	-4912
PLA2G6	-4717	-3132
PLB1	4419	-5279
PLD1	4274	-6058
PLD3	3212	1541
PLD6	-1122	2227
PLEKHA2	-429	-4384
PLEKHA3	-1556	-6547
PLEKHA6	-522	-2325
PLEKHA8	-918	-1764
PLIN2	3708	-96
PLIN3	4396	-3203
PMVK	1124	1829
PNPLA2	4155	-5698
PNPLA6	2892	-3173
PNPLA7	-1992	-1431
PNPLA8	3378	-3836
PON2	-1923	-4741
PPARD	-1877	660
PPARGC1B	-1554	1840
PPM1L	-937	-4324
PPP1CA	1462	550
PPP1CB	3008	1839
PPP1CC	2576	-754
PPT1	4135	-4371
PPT2	-4186	-5624
PRKAB2	-2683	-1428
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAG2	612	-5033
PRKD2	-3009	229
PSAP	2899	-4192
PTDSS2	2314	-1185
PTEN	3857	-1100
PTGES2	-2149	-1462
PTGES3	1472	-1810
PTGR1	4198	-6711
PTGR2	408	-3930
PTPMT1	730	414
PTPN13	-3647	-6489
RAB14	3005	1334
RAB4A	3589	-5479
RAB5A	3055	-1686
RAN	-2179	1257
RGL1	3304	1731
RORA	-4632	2287
RUFY1	2671	-4178
SACM1L	-3249	-1578
SAMD8	3344	-5347
SAR1B	2704	489
SBF1	-3855	882
SC5D	-1057	-6658
SCAP	-1221	-3851
SCD	1444	-6126
SCP2	1626	-5793
SEC23A	3198	-5141
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SGMS1	4072	-1653
SGPL1	1137	-2339
SGPP1	-4821	-5414
SIN3A	-3920	-4151
SIN3B	-1249	570
SLC22A5	2964	-5659
SLC25A1	1894	-910
SLC25A17	-3961	-4326
SLC25A20	1418	2245
SLC27A1	3788	-3528
SLC27A2	-1163	-6055
SLC27A3	-263	-1585
SLC27A5	-1091	-3060
SLC44A1	3856	2368
SLC44A2	878	2003
SMPD1	349	-28
SMPD2	749	-918
SMPD3	-4815	2463
SP1	3746	-3141
SPHK2	921	-2294
SPTLC1	3894	-5493
SPTLC2	3797	743
SPTLC3	640	1742
SPTSSA	1680	-5079
SQLE	1540	-5831
SRD5A1	3504	2146
SRD5A3	1437	442
SREBF1	2743	-4015
SREBF2	2838	-1852
STARD10	1789	-337
STARD3	1095	-5163
STARD3NL	3210	-4610
STARD4	-1209	-2360
STARD5	-906	-5368
STARD7	1166	-1506
SUMF1	4123	-5376
SUMF2	-4745	-3692
SYNJ1	2561	1501
SYNJ2	-2891	-6043
TBL1XR1	1687	962
TBXAS1	3948	-6709
TECR	-3287	-274
THEM4	-4101	-6129
TIAM2	-4202	-1035
TM7SF2	-2293	-1255
TNFAIP8	-166	1226
TNFAIP8L1	-3602	-4062
TNFAIP8L2	2242	-249
TRIB3	-1812	1669
TSPO	4360	-6553
TXNRD1	3738	-4647
UBE2I	-239	233
UGCG	731	1914
VAC14	-30	-2381
VAPA	4183	-5592
VAPB	702	-6771
VDR	3712	-3651

---

---

Signaling by NOTCH

Signaling by NOTCH

metric	value
setSize	130
pMANOVA	1.43e-07
p.adjustMANOVA	5.15e-06
s.dist	0.286
s.RNA	0.286
s.meth	-0.00581
p.RNA	2.09e-08
p.meth	0.909

Top 20 genes

Gene	RNA	meth
PLXND1	3176	-6504
PSMD6	3475	-5488
TACC3	4361	-4182
PSMD4	3846	-4683
PSMC1	3011	-5705
PSMB5	3671	-4604
MAML3	4122	-4054
NCSTN	4222	-3821
HDAC4	4171	-3817
PSMC6	2783	-5508
NCOR2	3521	-4281
TLE3	3950	-3798
ST3GAL6	2764	-5427
PSMF1	2794	-4867
RUNX1	3296	-4082
HDAC7	2424	-4900
PSEN1	3454	-3407
ST3GAL4	2345	-4996
EP300	2504	-4509
MAML1	2094	-5348

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTA2	-140	-3190
ADAM10	3964	976
ADAM17	3540	774
AGO1	2205	1997
AGO2	983	2447
AGO3	-318	-6442
AKT1	1248	-1942
APH1A	1483	-6066
APH1B	2525	2056
ARRB1	659	-6363
ARRB2	3858	-2243
ATP2A1	-1323	-4587
ATP2A2	3601	1489
ATP2A3	-315	1190
B4GALT1	1562	-160
CCNC	596	-1138
CCND1	-2169	-6213
CDK8	-597	-5509
CREB1	-423	-672
CREBBP	1169	-5804
CUL1	-4385	-5146
DLGAP5	1039	-2706
DTX4	2517	1530
E2F1	2654	-1005
E2F3	2805	-2884
EP300	2504	-4509
FBXW7	-2109	-5428
FURIN	4236	2351
HDAC1	124	-1016
HDAC10	737	-1304
HDAC11	1770	-3595
HDAC2	2158	-46
HDAC3	1740	-3771
HDAC4	4171	-3817
HDAC5	1755	-3144
HDAC7	2424	-4900
HEY2	-3510	2330
HIF1A	3192	-3349
IKZF1	-2546	1828
ITCH	429	-1366
JUN	1372	69
KAT2A	-3767	-5050
KAT2B	-704	-1588
LFNG	-2876	1932
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MFNG	-1824	-3250
MIB1	-895	-2718
MOV10	-4691	-6449
NBEA	-114	-6575
NCOR1	2375	-3738
NCOR2	3521	-4281
NCSTN	4222	-3821
NOTCH1	1739	1722
NOTCH4	-1578	-6455
NUMB	4383	-35
PLXND1	3176	-6504
POFUT1	673	973
PRKCI	-42	-4275
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSMF1	2794	-4867
RAB6A	3692	-311
RBPJ	3993	-1118
RBX1	1413	-3241
RPS27A	-2186	-2138
RUNX1	3296	-4082
SEL1L	2854	-2307
SIRT6	2566	-4139
SKP1	1561	-2290
SMAD3	-4431	-4628
SNW1	2003	946
ST3GAL3	152	-1055
ST3GAL4	2345	-4996
ST3GAL6	2764	-5427
STAT1	-4575	2195
TACC3	4361	-4182
TBL1XR1	1687	962
TFDP1	3847	-1587
TFDP2	-4878	-4793
TLE2	-1787	-3959
TLE3	3950	-3798
TLE4	2883	635
TMED2	2437	-3656
TNRC6A	-1702	-5420
TNRC6B	-1364	2270
TP53	-4078	-739
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
WWP2	3586	-718
YBX1	1033	-364
YWHAZ	2220	541

---

---

Signaling by NTRKs

Signaling by NTRKs

metric	value
setSize	90
pMANOVA	1.79e-07
p.adjustMANOVA	6.28e-06
s.dist	0.333
s.RNA	0.325
s.meth	0.0762
p.RNA	1.09e-07
p.meth	0.213

Top 20 genes

Gene	RNA	meth
CLTC	4170	2477
FURIN	4236	2351
PPP2CB	3404	1797
MAPK1	3257	1865
YWHAB	2609	2125
FOS	2486	2149
RHOA	3688	1313
RAC1	3977	971
FOSL1	4094	737
MAPKAPK2	1470	2012
DNM2	2474	738
RIT1	4242	337
PPP2CA	3740	300
RAP1A	3142	323
REST	304	2128
KIDINS220	3019	189
KRAS	1294	440
NELFB	121	1822
AP2M1	3947	20

Click HERE to show all gene set members

All member genes

	RNA	meth
ADORA2A	1055	-5935
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
ATF1	2271	-2565
BAX	2386	-3623
BRAF	406	-4347
CDK5	3942	-506
CDK5R1	-356	-2113
CHD4	-1372	-4634
CLTA	3793	-5077
CLTC	4170	2477
CREB1	-423	-672
CRK	4109	-4581
CRKL	1383	-906
DNAL4	1131	-45
DNM1	1196	-5619
DNM2	2474	738
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
EGR1	955	-163
EGR2	-635	-2628
EP300	2504	-4509
FOS	2486	2149
FOSB	441	-332
FOSL1	4094	737
FRS2	-1016	-1999
FRS3	3191	-2329
FURIN	4236	2351
FYN	-4569	1957
GRB2	4321	-2295
HRAS	-989	-4780
ID1	1788	-3980
ID2	-4116	566
ID3	-2928	1995
IRS1	563	-4060
IRS2	3752	-5410
JUNB	2887	-3031
JUND	480	-1239
KIDINS220	3019	189
KRAS	1294	440
LYL1	3750	-6435
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K5	1370	-3572
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MEF2D	-939	-3018
NAB1	407	-2731
NAB2	-3750	989
NELFB	121	1822
NTRK1	-2556	898
PCSK5	1809	-4883
PIK3CA	1725	-1445
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PLCG1	-3823	-3541
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PTPN11	2065	-2302
RAC1	3977	971
RALA	865	-262
RALB	3837	-1081
RALGDS	-4773	1254
RAP1A	3142	323
RAPGEF1	-3584	1868
REST	304	2128
RHOA	3688	1313
RIT1	4242	337
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SGK1	1695	-6076
SHC1	1469	-2954
SOS1	-1758	-6775
SRC	-3100	-4427
SRF	3082	-1284
STAT3	3649	-3606
TCF12	-384	-4702
VRK3	402	-1398
YWHAB	2609	2125

---

---

Influenza Infection

Influenza Infection

metric	value
setSize	128
pMANOVA	2.33e-07
p.adjustMANOVA	7.92e-06
s.dist	0.295
s.RNA	-0.185
s.meth	0.23
p.RNA	0.000309
p.meth	7.89e-06

Top 20 genes

Gene	RNA	meth
ISG15	-4761	1894
IPO5	-3937	1869
RPL3	-2866	2313
RPL23A	-3305	1843
NUP43	-3356	1617
RPL13A	-2702	1802
RPS11	-2281	2115
RPL32	-2060	1928
NUP210	-3968	910
NUP205	-4259	826
RPS2	-1347	2392
NUP160	-3773	763
RAN	-2179	1257
RPL35	-2748	952
RPL4	-1061	2321
RPS10	-1744	1246
RPS15	-1096	1808
RPS15A	-1748	1086
RPL17	-1666	1099
RPS3A	-1414	1275

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
CALR	2620	-3753
CANX	2138	-4839
CLTA	3793	-5077
CLTC	4170	2477
CPSF4	-3362	134
DNAJC3	3833	-2353
EIF2AK2	-3267	-3645
FAU	-129	-3862
GRSF1	1991	27
GTF2F1	1892	-1723
GTF2F2	2127	-2885
HSP90AA1	415	-781
HSPA1A	3666	-3825
IPO5	-3937	1869
ISG15	-4761	1894
KPNA1	409	-2889
KPNA2	-2167	-874
KPNA3	308	-897
KPNA4	1912	1716
KPNA5	-4625	-572
KPNB1	799	-2176
NDC1	-4771	-5228
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
PABPN1	-170	-3743
PARP1	-4461	-5521
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
POM121	-2762	-1787
POM121C	-2356	-4315
RAE1	1948	-39
RAN	-2179	1257
RANBP2	-259	-4704
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
SEC13	2286	-3749
SEH1L	-1833	-1615
TGFB1	1971	-6
TPR	-2272	-973
UBA52	344	752
XPO1	-371	-870

---

---

Interleukin-1 signaling

Interleukin-1 signaling

metric	value
setSize	78
pMANOVA	2.84e-07
p.adjustMANOVA	9.34e-06
s.dist	0.358
s.RNA	0.357
s.meth	0.0153
p.RNA	5.1e-08
p.meth	0.815

Top 20 genes

Gene	RNA	meth
NOD2	3786	1528
TAB2	2991	1892
PSMA7	3060	1752
PSMD1	3121	1660
CHUK	3527	1343
PSME3	3757	1116
MAP3K8	2531	1442
PSMD12	2688	1314
PSMB2	1441	2355
NFKBIA	2855	1159
PSMD13	2383	1328
PSMA2	2087	1205
UBE2N	616	1127
UBA52	344	752
MAP3K3	3766	64
PSMD7	2396	7

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
BTRC	-1491	-2427
CHUK	3527	1343
CUL1	-4385	-5146
FBXW11	2542	-6747
HMGB1	-66	-1263
IKBKB	-1620	-3894
IL1RAP	3160	-456
IRAK2	-3415	-1457
IRAK3	4111	-6295
MAP2K1	4120	-698
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP3K3	3766	64
MAP3K7	780	-2089
MAP3K8	2531	1442
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
RBX1	1413	-3241
RELA	-541	2085
RPS27A	-2186	-2138
SKP1	1561	-2290
SQSTM1	1450	-952
TAB2	2991	1892
TNIP2	2191	-5726
TOLLIP	3944	-5037
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2N	616	1127
UBE2V1	2217	-1021

---

---

ER to Golgi Anterograde Transport

ER to Golgi Anterograde Transport

metric	value
setSize	105
pMANOVA	3.05e-07
p.adjustMANOVA	9.75e-06
s.dist	0.307
s.RNA	0.306
s.meth	0.0249
p.RNA	6.47e-08
p.meth	0.661

Top 20 genes

Gene	RNA	meth
KDELR1	4237	1780
TMED7	3495	1939
PPP6C	2885	2020
GOLGA2	2510	1847
COPA	3748	1056
DCTN6	3179	819
CAPZA1	3657	572
USO1	1479	1196
SAR1B	2704	489
CTSC	817	1561
COPE	2941	213
SEC24A	3377	61
TMED10	104	604

Click HERE to show all gene set members

All member genes

	RNA	meth
ACTR10	3334	-1291
ACTR1A	3003	-1
ANK1	4083	-4221
ANK3	-1508	-6563
ANKRD28	-1964	-5108
ARCN1	2206	-1676
ARF1	4190	-6686
ARF3	3423	-1912
ARF4	4255	-3280
ARF5	3536	-4789
ARFGAP1	-583	1688
ARFGAP3	1308	-5386
BET1	-202	-4482
BET1L	-2386	332
CAPZA1	3657	572
CAPZA2	3861	-36
CAPZB	3594	-4065
CD55	4233	-3923
CD59	2365	-6024
CNIH1	3446	-6699
COG1	-4741	-3663
COG2	-2655	-6132
COG3	-1593	-5701
COG4	1	-984
COG5	-985	-1864
COG6	-1803	-358
COG7	1546	-4196
COG8	-131	1846
COPA	3748	1056
COPB1	3188	-1329
COPB2	3530	-1501
COPE	2941	213
COPZ1	1431	-5051
COPZ2	-4133	1305
CSNK1D	771	-1777
CTSC	817	1561
CTSZ	4137	-6765
DCTN2	4234	-6011
DCTN3	2429	-4272
DCTN4	3783	-2073
DCTN5	-1230	-5100
DCTN6	3179	819
DYNC1H1	-2569	1504
DYNC1I2	3322	-4337
DYNC1LI1	2948	-2912
DYNC1LI2	1506	-5470
DYNLL1	2413	-3319
DYNLL2	-1200	214
GBF1	-1292	-120
GOLGA2	2510	1847
GOLGB1	-1656	-3196
GORASP1	2763	-2178
GOSR1	-51	-3152
GOSR2	-462	1643
KDELR1	4237	1780
KDELR2	3293	-2980
LMAN1	-3951	596
LMAN2	3064	-2497
LMAN2L	2953	-1590
MCFD2	3037	-158
MIA3	-1970	-3428
NAPA	425	-4125
NAPB	-827	471
NAPG	1477	-97
PPP6C	2885	2020
PPP6R1	2037	-1276
PPP6R3	1102	-3726
RAB1A	4185	-1703
RAB1B	3794	-264
SAR1B	2704	489
SEC13	2286	-3749
SEC16A	1717	-1722
SEC22A	-1547	696
SEC22C	-1274	1879
SEC23A	3198	-5141
SEC23IP	-149	-38
SEC24A	3377	61
SEC24B	1247	-5505
SEC24C	-784	805
SEC24D	3635	-3966
SEC31A	362	-4985
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
STX17	-4112	-4247
STX5	3070	-1823
TBC1D20	-16	-5205
TGFA	4154	-3020
TMED10	104	604
TMED2	2437	-3656
TMED3	893	-2936
TMED7	3495	1939
TMED9	3079	-1992
TMEM115	2179	-703
TRAPPC1	3480	-3029
TRAPPC10	-3321	2388
TRAPPC2L	-690	1441
TRAPPC3	3050	-2853
TRAPPC4	-2164	-3231
TRAPPC5	2001	-5629
TRAPPC6A	-4070	1765
TRAPPC6B	1486	-662
TRAPPC9	2076	-4354
USO1	1479	1196
YKT6	2009	-3331

---

---

tRNA processing

tRNA processing

metric	value
setSize	93
pMANOVA	3.59e-07
p.adjustMANOVA	1.12e-05
s.dist	0.335
s.RNA	-0.317
s.meth	0.108
p.RNA	1.34e-07
p.meth	0.0718

Top 20 genes

Gene	RNA	meth
ADAT1	-3252	1883
NUP43	-3356	1617
FAM98B	-2764	1741
NUP210	-3968	910
NUP205	-4259	826
RPP38	-2173	1598
NUP160	-3773	763
RAN	-2179	1257
POP4	-1127	2076
NUP153	-1967	834
AAAS	-2797	405
TRMT1	-909	1178
CPSF4	-3362	134
PUS7	-1605	263
NUP85	-920	317
NUP133	-2577	112
TYW5	-375	485
TRMT12	-128	956
NSUN2	-564	65

Click HERE to show all gene set members

All member genes

	RNA	meth
AAAS	-2797	405
ADAT1	-3252	1883
ADAT2	-3392	-2393
ADAT3	348	1001
ALKBH8	-4470	-3991
C2orf49	-1773	-443
CDKAL1	-3229	-2998
CLP1	2775	-1417
CPSF1	-1130	-6284
CPSF4	-3362	134
CTU1	1703	-3154
CTU2	-3002	-2262
DDX1	-844	-558
DUS2	1189	2247
ELAC2	-4602	-916
FAM98B	-2764	1741
GTPBP3	-2331	-3838
LCMT2	-3688	-441
METTL1	-2158	-5208
MTO1	-2863	-856
NDC1	-4771	-5228
NSUN2	-564	65
NSUN6	-2372	-2844
NUP107	-3879	-1197
NUP133	-2577	112
NUP153	-1967	834
NUP155	-3725	-4352
NUP160	-3773	763
NUP188	-4434	-847
NUP205	-4259	826
NUP210	-3968	910
NUP214	3562	1119
NUP35	-3680	-321
NUP37	1026	-1886
NUP43	-3356	1617
NUP50	1654	1760
NUP54	-2886	-2767
NUP62	245	-980
NUP85	-920	317
NUP88	-4132	-128
NUP93	-4533	-3462
NUP98	1015	315
POM121	-2762	-1787
POM121C	-2356	-4315
POP1	-1219	-517
POP4	-1127	2076
POP5	-3228	-4690
POP7	1489	466
PUS1	-1871	-1746
PUS3	1252	-5241
PUS7	-1605	263
QTRT1	-3156	-3239
RAE1	1948	-39
RAN	-2179	1257
RANBP2	-259	-4704
RPP14	1011	-354
RPP21	-1592	-5256
RPP25	-2803	-5917
RPP30	-2733	-5522
RPP38	-2173	1598
RPP40	-1422	-1426
RPPH1	557	-5149
RTCB	-407	-261
SEC13	2286	-3749
SEH1L	-1833	-1615
THADA	-4579	-3826
THG1L	-3944	-2349
TP53RK	-4658	-2342
TPR	-2272	-973
TPRKB	-1589	-2506
TRDMT1	295	-4357
TRIT1	244	-2615
TRMT1	-909	1178
TRMT10A	2917	-5299
TRMT11	-4074	-4066
TRMT112	184	-4666
TRMT12	-128	956
TRMT44	-2070	-1269
TRMT6	2306	1951
TRMT61A	-3309	-4239
TRMT61B	-2646	-2862
TRMU	-3167	-1879
TRNT1	-2488	-1006
TSEN15	-3616	-3075
TSEN2	-4098	-3251
TSEN34	3312	-751
TSEN54	-4822	-550
TYW1	-3213	-820
TYW3	-2744	-4913
TYW5	-375	485
URM1	-373	-3584
XPOT	-810	-828
ZBTB8OS	1538	-1338

---

---

Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

metric	value
setSize	45
pMANOVA	5.91e-07
p.adjustMANOVA	1.79e-05
s.dist	0.461
s.RNA	0.461
s.meth	-0.012
p.RNA	8.93e-08
p.meth	0.889

Top 20 genes

Gene	RNA	meth
CYFIP1	4286	-6630
SYK	4194	-5054
NCKAP1L	3255	-6178
ACTB	4172	-4515
CRK	4109	-4581
ARPC5	3937	-3837
PAK1	3707	-3995
ARPC3	3741	-3767
VAV3	1853	-6342
ARPC2	3217	-3647
ACTR2	3442	-3374
VAV1	3569	-3184
MAPK3	4187	-2448
ACTR3	3481	-2917
WASF2	3777	-2654
GRB2	4321	-2295
CDC42	3265	-2719
ARPC1B	4309	-2022
ELMO1	2569	-2714
LIMK1	1743	-3787

Click HERE to show all gene set members

All member genes

	RNA	meth
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
BAIAP2	-56	1977
BRK1	3002	1970
CD247	-4870	2098
CDC42	3265	-2719
CFL1	3703	912
CRK	4109	-4581
CYFIP1	4286	-6630
CYFIP2	-3776	2232
ELMO1	2569	-2714
ELMO2	1638	1326
GRB2	4321	-2295
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
LIMK1	1743	-3787
MAPK1	3257	1865
MAPK3	4187	-2448
MYH9	2818	2182
MYO9B	2658	687
NCK1	-4400	-1408
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NF2	-2071	-2754
PAK1	3707	-3995
PTK2	1637	920
RAC1	3977	971
SYK	4194	-5054
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WIPF1	182	-4382
WIPF2	2264	-2523

---

---

Response to elevated platelet cytosolic Ca2+

Response to elevated platelet cytosolic Ca2+

metric	value
setSize	53
pMANOVA	6.98e-07
p.adjustMANOVA	2.06e-05
s.dist	0.421
s.RNA	0.421
s.meth	0.00661
p.RNA	1.17e-07
p.meth	0.934

Top 20 genes

Gene	RNA	meth
ACTN1	4259	2335
WDR1	2980	2364
CALU	3485	1252
CFL1	3703	912
PFN1	2155	833
MANF	813	1947
TLN1	3884	191
PRKCA	368	810

Click HERE to show all gene set members

All member genes

	RNA	meth
A1BG	2185	-3533
ABCC4	3277	-3153
ACTN1	4259	2335
ACTN4	1939	-2928
ALDOA	4289	-1349
ANXA5	3631	-2845
APLP2	4302	-3465
APP	4212	-5300
BRPF3	-2021	-937
CALM1	-614	-5019
CALU	3485	1252
CAP1	3678	-553
CD63	4327	-1017
CDC37L1	-2833	1097
CFL1	3703	912
CHID1	904	-254
CYB5R1	4410	-1352
ENDOD1	1143	-4107
FAM3C	-3567	527
FERMT3	4298	-1343
GTPBP2	2596	-487
HABP4	-4095	230
MANF	813	1947
NHLRC2	-2578	-716
OLA1	1868	-508
PCYOX1L	-587	339
PFN1	2155	833
PHACTR2	2128	-6672
PLEK	667	-5891
PPIA	-2188	490
PRKCA	368	810
PRKCB	2983	-4518
PSAP	2899	-4192
QSOX1	4308	-1087
SCCPDH	3498	-5477
SOD1	-1490	-1019
SRGN	4017	-2722
STX4	200	-6001
STXBP2	4178	-6352
STXBP3	3213	-1306
TAGLN2	3219	-1136
TEX264	-2862	55
TGFB1	1971	-6
TGFB2	-2458	-6761
TGFB3	-2516	-5946
TLN1	3884	191
TMX3	-255	-6313
TOR4A	4106	-6704
TUBA4A	2717	-4571
VCL	3178	-5870
VEGFA	3184	-2723
VTI1B	4081	-359
WDR1	2980	2364

---

---

Toll-like Receptor Cascades

Toll-like Receptor Cascades

metric	value
setSize	107
pMANOVA	8.29e-07
p.adjustMANOVA	2.38e-05
s.dist	0.295
s.RNA	0.295
s.meth	0.00505
p.RNA	1.4e-07
p.meth	0.928

Top 20 genes

Gene	RNA	meth
TLR5	4278	1823
PPP2CB	3404	1797
MAPK1	3257	1865
NOD2	3786	1528
TAB2	2991	1892
ITGB2	4091	1322
FOS	2486	2149
CHUK	3527	1343
IKBKE	1764	2086
MAP3K8	2531	1442
NFKBIA	2855	1159
MAPKAPK2	1470	2012
DNM2	2474	738
PPP2CA	3740	300
UBE2N	616	1127
UBA52	344	752
JUN	1372	69

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
ATF1	2271	-2565
BIRC2	1750	-1862
BIRC3	-4025	-2320
BTRC	-1491	-2427
CASP8	-4381	387
CHUK	3527	1343
CNPY3	3445	-3161
CREB1	-423	-672
CTSB	4310	-4209
CTSL	1667	-6671
CTSS	3735	-2958
CTSV	-848	-5834
CUL1	-4385	-5146
DNM1	1196	-5619
DNM2	2474	738
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
ECSIT	1866	-4938
EEA1	1690	-711
FADD	2255	-6328
FBXW11	2542	-6747
FOS	2486	2149
HMGB1	-66	-1263
HSP90B1	655	-1371
IKBKB	-1620	-3894
IKBKE	1764	2086
IRAK2	-3415	-1457
IRAK3	4111	-6295
IRF3	-2867	542
IRF7	-3037	1622
ITGB2	4091	1322
JUN	1372	69
LGMN	-1423	313
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PIK3R4	-1199	-3425
PLCG2	1926	-2562
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PTPN11	2065	-2302
PTPN4	-4781	-3156
RBSN	-1371	-2813
RELA	-541	2085
RIPK3	1514	-370
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SARM1	-4686	-5412
SIGIRR	-3945	290
SKP1	1561	-2290
SOCS1	1346	-2999
TAB2	2991	1892
TANK	3243	-1331
TBK1	1029	-4616
TICAM1	2598	-2136
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR3	-4429	-5820
TLR5	4278	1823
TLR6	4103	-802
TLR9	-1815	2292
TNIP2	2191	-5726
TRAF3	-1622	2379
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2N	616	1127
UBE2V1	2217	-1021
UNC93B1	1454	-4358
VRK3	402	-1398

---

---

Peptide chain elongation

Peptide chain elongation

metric	value
setSize	67
pMANOVA	9.08e-07
p.adjustMANOVA	2.54e-05
s.dist	0.388
s.RNA	-0.246
s.meth	0.3
p.RNA	0.000505
p.meth	2.26e-05

Top 20 genes

Gene	RNA	meth
RPL3	-2866	2313
RPL23A	-3305	1843
RPL13A	-2702	1802
RPS11	-2281	2115
RPL32	-2060	1928
RPS2	-1347	2392
RPL35	-2748	952
RPL4	-1061	2321
RPS10	-1744	1246
RPS15	-1096	1808
RPS15A	-1748	1086
RPL17	-1666	1099
RPS3A	-1414	1275
RPS16	-1369	1043
RPLP2	-2194	579
RPS8	-638	1886
EEF1A1	-1543	720
RPS28	-1398	525
RPS25	-1938	254
RPL6	-1002	474

Click HERE to show all gene set members

All member genes

	RNA	meth
EEF1A1	-1543	720
EEF2	93	2127
FAU	-129	-3862
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
UBA52	344	752

---

---

Leishmania infection

Leishmania infection

metric	value
setSize	109
pMANOVA	1.03e-06
p.adjustMANOVA	2.82e-05
s.dist	0.295
s.RNA	0.291
s.meth	-0.052
p.RNA	1.73e-07
p.meth	0.35

Top 20 genes

Gene	RNA	meth
GGT1	4400	-6607
HRH2	4409	-6490
CYFIP1	4286	-6630
ADM	4381	-6151
PRKACA	4377	-6032
PYCARD	3986	-6598
NLRP3	4033	-6357
C3AR1	3600	-6729
SYK	4194	-5054
NCKAP1L	3255	-6178
FGR	3790	-5292
ACTB	4172	-4515
CRK	4109	-4581
GNB4	3039	-6007
ARPC5	3937	-3837
MAPK14	4264	-3529
ITPR2	2339	-6107
ARPC3	3741	-3767
ADCY4	1985	-6389
VAV3	1853	-6342

Click HERE to show all gene set members

All member genes

	RNA	meth
ABI1	3047	-1788
ABI2	-4058	-5451
ABL1	69	-4891
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ADAM17	3540	774
ADCY4	1985	-6389
ADCY7	-982	-5596
ADCY9	46	-2618
ADM	4381	-6151
ADORA2A	1055	-5935
ADRB2	-4638	-3531
AHCYL1	2655	-3553
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
BAIAP2	-56	1977
BRK1	3002	1970
C3AR1	3600	-6729
CALM1	-614	-5019
CASP1	1434	-1448
CD247	-4870	2098
CDC42	3265	-2719
CREB1	-423	-672
CRK	4109	-4581
CYBA	2925	1006
CYFIP1	4286	-6630
CYFIP2	-3776	2232
DPEP2	-826	-6530
DVL1	19	-4520
DVL2	-3982	-1356
DVL3	2248	-3704
ELMO1	2569	-2714
ELMO2	1638	1326
ENTPD1	3776	2446
ENTPD5	-1942	-4305
FGR	3790	-5292
FURIN	4236	2351
FYN	-4569	1957
FZD7	-2029	-3834
GGT1	4400	-6607
GIPR	-4760	-2380
GNAI2	3614	-1747
GNAI3	3575	-909
GNAS	3567	951
GNB1	3726	-2920
GNB2	3700	-309
GNB4	3039	-6007
GNB5	146	1821
GNG2	-2564	-3847
GNG3	288	2231
GNG4	-651	2073
GNG5	4068	1920
GNG7	-1535	-4773
GNGT2	-4747	2438
GRB2	4321	-2295
HRH2	4409	-6490
HSP90AB1	-2106	-5745
ITPR1	-2461	-3278
ITPR2	2339	-6107
ITPR3	-3534	-3427
JUN	1372	69
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK8	-3380	6
MYH9	2818	2182
MYO9B	2658	687
NCK1	-4400	-1408
NCKAP1L	3255	-6178
NCKIPSD	102	-4332
NFKB2	-279	388
NLRP3	4033	-6357
NOXA1	-1687	-5872
P2RX4	3391	174
PLCG1	-3823	-3541
PLCG2	1926	-2562
PLK2	-832	-6257
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAR1A	3915	-201
PRKAR1B	3583	731
PRKAR2A	2533	-4298
PSTPIP1	3510	1135
PTGER2	447	-5853
PTGER4	-4573	1153
PTK2	1637	920
PYCARD	3986	-6598
RAC1	3977	971
RELA	-541	2085
RHBDF2	1487	-4959
SRC	-3100	-4427
SUGT1	483	594
SYK	4194	-5054
TXN	3798	284
TXNIP	-3453	-2777
VAV1	3569	-3184
VAV2	-1215	-643
VAV3	1853	-6342
VIPR1	-1885	-3480
WASF1	4426	-1056
WASF2	3777	-2654
WASL	91	-4742
WIPF1	182	-4382
WIPF2	2264	-2523
YES1	-4790	-4415

---

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

metric	value
setSize	70
pMANOVA	1.08e-06
p.adjustMANOVA	2.89e-05
s.dist	0.377
s.RNA	-0.24
s.meth	0.291
p.RNA	0.000537
p.meth	2.6e-05

Top 20 genes

Gene	RNA	meth
RPL3	-2866	2313
RPL23A	-3305	1843
RPL13A	-2702	1802
RPS11	-2281	2115
RPL32	-2060	1928
RPS2	-1347	2392
RPL35	-2748	952
RPL4	-1061	2321
EEF1B2	-1279	1717
RPS10	-1744	1246
RPS15	-1096	1808
RPS15A	-1748	1086
RPL17	-1666	1099
RPS3A	-1414	1275
RPS16	-1369	1043
RPLP2	-2194	579
RPS8	-638	1886
EEF1A1	-1543	720
RPS28	-1398	525
RPS25	-1938	254

Click HERE to show all gene set members

All member genes

	RNA	meth
EEF1A1	-1543	720
EEF1B2	-1279	1717
EEF1D	-269	-885
EEF1G	-443	-5880
EEF2	93	2127
FAU	-129	-3862
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
UBA52	344	752

---

---

Developmental Biology

Developmental Biology

metric	value
setSize	449
pMANOVA	1.11e-06
p.adjustMANOVA	2.89e-05
s.dist	0.146
s.RNA	0.146
s.meth	-0.00732
p.RNA	1.66e-07
p.meth	0.793

Top 20 genes

Gene	RNA	meth
SEMA4A	4164	-6718
SPI1	4090	-6766
FES	4294	-6334
ACVR1B	4205	-6300
PRKACA	4377	-6032
CEBPA	3784	-6768
CAPN1	3912	-6119
IL6R	3697	-6410
ITGA5	3362	-6767
RPS6KA1	3425	-6629
LIMK2	3673	-6093
GAB2	3616	-6153
TYROBP	3294	-6720
MPZ	3502	-6222
CEBPE	3216	-6744
PDLIM7	4152	-5081
NR6A1	3935	-5344
CEBPD	4041	-5142
HHEX	3170	-6522
PLXND1	3176	-6504

Click HERE to show all gene set members

All member genes

	RNA	meth
ABL1	69	-4891
ABL2	1563	301
ABLIM1	-3512	-4330
ABLIM2	-3498	-5662
ACTB	4172	-4515
ACTG1	3946	1793
ACTR2	3442	-3374
ACTR3	3481	-2917
ACVR1B	4205	-6300
ACVR2A	-4355	-4829
ADAM10	3964	976
ADAM11	-3201	-2252
ADAM22	-4048	-2633
AGAP2	-1798	-3508
AGRN	-4590	-2304
AJUBA	-2581	-2301
AKT1	1248	-1942
AKT2	108	-141
ALCAM	4320	-1377
ANK1	4083	-4221
ANK3	-1508	-6563
AP2A1	2735	-4887
AP2M1	3947	20
AP2S1	3606	-3262
APH1A	1483	-6066
APH1B	2525	2056
ARHGAP35	-1007	-3660
ARHGAP39	-2401	-5852
ARHGEF12	1058	-4362
ARHGEF7	-1390	-5507
ARPC1B	4309	-2022
ARPC2	3217	-3647
ARPC3	3741	-3767
ARPC5	3937	-3837
ASH2L	2381	-3791
BNIP2	3928	-1121
CACNA1C	-3959	-4608
CACNA1I	-1328	-5788
CACNB3	110	-6297
CAP1	3678	-553
CAPN1	3912	-6119
CAPNS1	3303	-2032
CASC3	2017	-2580
CBFB	680	-3766
CCNC	596	-1138
CCND3	3252	905
CD72	-1418	-4837
CDC42	3265	-2719
CDK19	3360	-2575
CDK2	-1524	1018
CDK4	-4195	-1295
CDK5	3942	-506
CDK5R1	-356	-2113
CDK8	-597	-5509
CDKN1A	1606	-3540
CDON	-2371	-2931
CEBPA	3784	-6768
CEBPB	3621	-5089
CEBPD	4041	-5142
CEBPE	3216	-6744
CFL1	3703	912
CHD9	-1356	-5791
CLASP1	-182	-390
CLASP2	-647	-4366
CLTA	3793	-5077
CLTB	2497	-3627
CLTC	4170	2477
CLTCL1	4107	-4995
CNOT6	1776	-3728
CNTNAP1	-1581	-313
COL9A2	-3547	-2895
CREB1	-423	-672
CREBBP	1169	-5804
CSNK2A2	2630	-4422
CSNK2B	1384	-998
CTCF	-3266	764
CTNNB1	2647	-1691
CUL2	821	-1212
CXCR4	-37	-1660
CYP51A1	2920	-5191
DAG1	-2435	-146
DEK	854	1060
DLG1	-2798	-3985
DLG4	4181	-3021
DNM1	1196	-5619
DNM2	2474	738
DOK2	-270	-2493
DOK4	819	-661
DPYSL2	3513	-108
DRAP1	-2200	-2142
E2F1	2654	-1005
EED	-3277	-1174
EFNA3	-2669	568
EFNA4	2511	-3312
EFNB2	-1951	-5564
EGR2	-635	-2628
EIF4A3	3171	-3850
EIF4G1	3607	746
EP300	2504	-4509
EPAS1	3555	535
EPHA4	-4171	630
EPHB6	58	-5408
ERBB2	-4860	-5145
ETF1	3196	758
EVL	-4735	2303
EZH2	-3517	-20
EZR	-4614	1610
FAM120B	-9	-2607
FARP2	-3251	1936
FAU	-129	-3862
FES	4294	-6334
FLI1	2171	-573
FOXO1	-3171	-5036
FOXO3	3983	711
FOXP1	-2951	881
FRS2	-1016	-1999
FURIN	4236	2351
FYN	-4569	1957
GAB2	3616	-6153
GFI1	-4703	-2672
GIT1	-3313	-6740
GRB10	4408	-70
GRB2	4321	-2295
GSK3B	2793	736
GSPT1	2706	-4456
HDAC2	2158	-46
HDAC3	1740	-3771
HHEX	3170	-6522
HMGCR	3683	-3388
HOXA1	-3239	-1478
HRAS	-989	-4780
HSP90AA1	415	-781
HSP90AB1	-2106	-5745
IL6R	3697	-6410
IRS2	3752	-5410
ITGA1	4037	-4187
ITGA2	1463	-3856
ITGA5	3362	-6767
ITGAV	2458	-5201
ITSN1	4248	-1048
JUN	1372	69
KAT2A	-3767	-5050
KAT2B	-704	-1588
KLF5	1899	-6396
KMT2A	-3933	2484
KMT2C	22	-6379
KMT2D	1065	-6199
KRAS	1294	440
KRT10	274	-286
LAMA2	-3513	-1315
LDB1	-3409	1270
LIMK1	1743	-3787
LIMK2	3673	-6093
LYPLA2	2922	-782
MAML1	2094	-5348
MAML2	-151	-2078
MAML3	4122	-4054
MAP2K1	4120	-698
MAP2K2	2898	-3962
MAP2K6	4145	-1130
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MBP	-1823	-4838
MED1	-1217	-2271
MED10	-2937	-2572
MED11	-225	609
MED13	824	590
MED13L	2446	-533
MED15	-3549	2114
MED16	2032	1719
MED17	967	-1418
MED18	1632	-186
MED19	1088	-4664
MED20	2864	-542
MED21	-1738	-582
MED22	1282	-2059
MED23	-2103	633
MED24	-2416	-2701
MED25	2547	-1286
MED26	1615	18
MED27	-3240	-960
MED28	-424	699
MED29	-2664	-5128
MED30	-1688	491
MED31	456	445
MED4	1079	-4472
MED6	-284	560
MED7	55	778
MED8	3319	1289
MED9	-3072	-3399
MEF2A	3577	-2822
MEF2D	-939	-3018
MPZ	3502	-6222
MYB	176	1502
MYH10	214	-4405
MYH9	2818	2182
MYL12A	2942	-2655
MYL6	3953	-19
MYO9B	2658	687
NAB1	407	-2731
NAB2	-3750	989
NCBP1	-1800	-3745
NCBP2	-3367	-4067
NCK1	-4400	-1408
NCK2	1874	-4310
NCOA2	352	1407
NCOA3	1207	-2266
NCOA6	2298	-1860
NCOR1	2375	-3738
NCOR2	3521	-4281
NCSTN	4222	-3821
NEO1	-3530	-4340
NOTCH1	1739	1722
NR6A1	3935	-5344
NTN1	-1419	-2727
NUMB	4383	-35
ONECUT1	807	-6035
PABPC1	2073	-2769
PAGR1	2021	2336
PAK1	3707	-3995
PAK2	3694	-3961
PAK4	-460	-1464
PAXIP1	-3033	-3883
PDLIM7	4152	-5081
PFN1	2155	833
PFN2	-701	-6463
PIAS2	-2497	-2314
PIK3CA	1725	-1445
PIK3CD	2436	2189
PIK3R1	-3418	2310
PIK3R2	1897	-1223
PIK3R3	-4729	-22
PIP5K1C	1156	-5383
PITPNA	2872	-2752
PKNOX1	-799	1315
PKP4	1013	-5121
PLCG1	-3823	-3541
PLXNA2	2966	634
PLXNC1	4265	-3505
PLXND1	3176	-6504
PML	-3036	549
POLR2A	-934	-3832
POLR2B	-753	926
POLR2C	469	1027
POLR2D	-1206	-2419
POLR2E	3337	-1584
POLR2F	1698	-4483
POLR2G	1214	-2402
POLR2H	-849	1944
POLR2I	101	-5210
POLR2K	-536	-2424
PPP3CB	2950	517
PRKACA	4377	-6032
PRKACB	-4623	455
PRKAR2A	2533	-4298
PRKCA	368	810
PRKCQ	-4731	1372
PRNP	1521	-4177
PSEN1	3454	-3407
PSEN2	-2579	-5155
PSENEN	2293	-3620
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTK2	1637	920
PTPN11	2065	-2302
PTPRA	-1354	1436
PTPRC	715	-1407
RAC1	3977	971
RANBP9	2336	-1361
RARA	2591	-5249
RARG	-1454	-5402
RASA1	674	-167
RBBP4	-573	-3282
RBBP5	325	-779
RBPJ	3993	-1118
RBX1	1413	-3241
RELA	-541	2085
RHOA	3688	1313
RHOB	378	-4992
RND1	-448	-2463
RNPS1	-4416	-3160
ROCK1	3215	-985
RPL10A	-2082	-648
RPL11	-1948	-2771
RPL13	-1025	-191
RPL13A	-2702	1802
RPL14	-2036	-100
RPL15	-319	-4694
RPL17	-1666	1099
RPL18	-1537	-2031
RPL18A	-1859	-4966
RPL22	-1428	-3996
RPL23	-996	-566
RPL23A	-3305	1843
RPL26	-2080	-1489
RPL26L1	3127	-2860
RPL27A	-1966	-55
RPL28	-450	-3478
RPL29	-1067	305
RPL3	-2866	2313
RPL31	-1346	-2278
RPL32	-2060	1928
RPL34	-2153	-3159
RPL35	-2748	952
RPL36	-1617	4
RPL36AL	30	1901
RPL37	-1993	-126
RPL37A	-1188	211
RPL38	-1809	-818
RPL39L	-3086	-329
RPL4	-1061	2321
RPL41	-2182	-229
RPL6	-1002	474
RPL7	-602	-6019
RPL8	-379	-5267
RPL9	-548	741
RPLP0	-325	-185
RPLP1	-21	-4053
RPLP2	-2194	579
RPS10	-1744	1246
RPS11	-2281	2115
RPS12	-1846	-379
RPS15	-1096	1808
RPS15A	-1748	1086
RPS16	-1369	1043
RPS18	-2506	-3281
RPS19	-2244	-4563
RPS2	-1347	2392
RPS20	-3053	-1962
RPS23	-1950	-1981
RPS24	-96	-2012
RPS25	-1938	254
RPS26	-438	-3094
RPS27A	-2186	-2138
RPS27L	665	-2218
RPS28	-1398	525
RPS29	-2558	-159
RPS3	-1790	-632
RPS3A	-1414	1275
RPS5	-1671	-1026
RPS6	-1881	-1785
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA4	631	-6624
RPS6KA5	-4480	-514
RPS7	-1523	-2594
RPS8	-638	1886
RPS9	2123	139
RPSA	-1929	-1486
RRAS	1251	420
RUNX1	3296	-4082
SDCBP	4350	-2535
SEMA3A	-1805	-6089
SEMA4A	4164	-6718
SEMA4D	-828	2276
SEMA7A	-3111	-4299
SHC1	1469	-2954
SIAH1	-897	-6217
SIAH2	3939	2185
SLIT1	1791	-6622
SMAD2	1836	-1994
SMAD3	-4431	-4628
SMAD4	-2765	-6535
SMARCA4	1769	2317
SNW1	2003	946
SOS1	-1758	-6775
SOS2	3767	-4105
SPAG9	1797	-4933
SPI1	4090	-6766
SPTAN1	-4369	-1250
SPTBN1	-2398	-3924
SPTBN5	-1020	2344
SRC	-3100	-4427
SREBF1	2743	-4015
SREBF2	2838	-1852
SRGAP1	2796	-6096
SRGAP3	-1765	-4649
ST8SIA4	3717	-3013
STAT3	3649	-3606
STX1A	-1208	-2461
STX1B	-888	-6167
TBL1XR1	1687	962
TCF12	-384	-4702
TCF3	-2132	-6049
TFDP1	3847	-1587
TFDP2	-4878	-4793
TGFB1	1971	-6
TLN1	3884	191
TNF	-2330	-3779
TRIO	571	-5812
TRPC1	-3275	-2704
TSC22D1	1700	-5391
TYROBP	3294	-6720
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UPF2	319	-1572
UPF3A	-3597	2175
USP33	-260	-5582
UTRN	-4663	1312
VASP	3638	-2892
VAV2	-1215	-643
VAV3	1853	-6342
WASL	91	-4742
WDR5	39	-5613
WNT1	-2892	-5360
YES1	-4790	-4415
YY1	169	-5165
ZNF335	-2561	-44
ZNF638	1335	1335
ZSWIM8	2072	-5960

---

---

Apoptosis

Apoptosis

metric	value
setSize	131
pMANOVA	1.4e-06
p.adjustMANOVA	3.35e-05
s.dist	0.259
s.RNA	0.254
s.meth	0.0484
p.RNA	5.52e-07
p.meth	0.341

Top 20 genes

Gene	RNA	meth
MAPK1	3257	1865
BCL2L11	3144	1781
YWHAB	2609	2125
TNFRSF10B	3810	1433
PSMA7	3060	1752
BCL2L1	4028	1306
PSMD1	3121	1660
PSME3	3757	1116
PSMD12	2688	1314
PSMB2	1441	2355
PSMD13	2383	1328
PSMA2	2087	1205
PRKCD	4146	584
BID	2427	844
PTK2	1637	920
CARD8	1766	794
YWHAZ	2220	541
PLEC	1721	385
CFLAR	3336	197
UBA52	344	752

Click HERE to show all gene set members

All member genes

	RNA	meth
ACIN1	268	-1699
ADD1	2270	-89
AKT1	1248	-1942
AKT2	108	-141
APAF1	4182	-2104
APC	1087	-4775
APPL1	109	28
ARHGAP10	-3063	2322
AVEN	-2718	1579
BAD	2952	-1382
BAK1	-105	-4022
BAX	2386	-3623
BBC3	-2642	-3845
BCL2	-1339	2361
BCL2L1	4028	1306
BCL2L11	3144	1781
BID	2427	844
BIRC2	1750	-1862
BMF	1590	-6386
C1QBP	-287	-2507
CARD8	1766	794
CASP3	-160	-2764
CASP6	-862	-4898
CASP7	15	-842
CASP8	-4381	387
CASP9	3414	-234
CDKN2A	-1623	-4511
CFLAR	3336	197
CLSPN	1301	-1524
CTNNB1	2647	-1691
CYCS	-386	-3927
DAPK2	3159	-2374
DAPK3	1666	-4978
DBNL	3466	-3713
DFFA	1129	-3179
DFFB	-2134	-4631
DIABLO	-2018	-5548
DNM1L	985	-5217
DYNLL1	2413	-3319
DYNLL2	-1200	214
E2F1	2654	-1005
FADD	2255	-6328
FAS	1270	-5824
FNTA	-1750	1499
HMGB1	-66	-1263
HMGB2	3949	-5133
KPNA1	409	-2889
KPNB1	799	-2176
LMNA	1334	-6474
LMNB1	4362	-942
MAPK1	3257	1865
MAPK3	4187	-2448
MAPK8	-3380	6
MAPT	-1660	2342
NMT1	1591	-3001
OMA1	964	-5732
OPA1	871	-4730
PAK2	3694	-3961
PLEC	1721	385
PMAIP1	-4153	-2202
PPP1R13B	-4370	1874
PPP3CC	-4723	1250
PPP3R1	3702	-3276
PRKCD	4146	584
PRKCQ	-4731	1372
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTK2	1637	920
ROCK1	3215	-985
RPS27A	-2186	-2138
SATB1	-2483	-1979
SFN	478	-5994
SPTAN1	-4369	-1250
STAT3	3649	-3606
STK24	2615	-1640
TFDP1	3847	-1587
TFDP2	-4878	-4793
TICAM1	2598	-2136
TJP2	1474	-67
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFSF10	931	-2143
TP53	-4078	-739
TP53BP2	2173	-5830
TRADD	-173	-1481
TRAF2	-4465	-1442
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
VIM	4364	-2247
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541

---

---

Toll Like Receptor 4 (TLR4) Cascade

Toll Like Receptor 4 (TLR4) Cascade

metric	value
setSize	93
pMANOVA	1.43e-06
p.adjustMANOVA	3.35e-05
s.dist	0.309
s.RNA	0.308
s.meth	0.0224
p.RNA	2.97e-07
p.meth	0.709

Top 20 genes

Gene	RNA	meth
PPP2CB	3404	1797
MAPK1	3257	1865
NOD2	3786	1528
TAB2	2991	1892
ITGB2	4091	1322
FOS	2486	2149
CHUK	3527	1343
IKBKE	1764	2086
MAP3K8	2531	1442
NFKBIA	2855	1159
MAPKAPK2	1470	2012
DNM2	2474	738
PPP2CA	3740	300
UBE2N	616	1127
UBA52	344	752
JUN	1372	69

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
ATF1	2271	-2565
BIRC2	1750	-1862
BIRC3	-4025	-2320
BTRC	-1491	-2427
CASP8	-4381	387
CHUK	3527	1343
CREB1	-423	-672
CUL1	-4385	-5146
DNM1	1196	-5619
DNM2	2474	738
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
ECSIT	1866	-4938
FADD	2255	-6328
FBXW11	2542	-6747
FOS	2486	2149
HMGB1	-66	-1263
IKBKB	-1620	-3894
IKBKE	1764	2086
IRAK2	-3415	-1457
IRAK3	4111	-6295
IRF3	-2867	542
IRF7	-3037	1622
ITGB2	4091	1322
JUN	1372	69
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PLCG2	1926	-2562
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
PTPN11	2065	-2302
PTPN4	-4781	-3156
RELA	-541	2085
RIPK3	1514	-370
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SARM1	-4686	-5412
SIGIRR	-3945	290
SKP1	1561	-2290
SOCS1	1346	-2999
TAB2	2991	1892
TANK	3243	-1331
TBK1	1029	-4616
TICAM1	2598	-2136
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR6	4103	-802
TNIP2	2191	-5726
TRAF3	-1622	2379
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2D1	4213	-1581
UBE2D2	1736	-3799
UBE2D3	3969	-373
UBE2N	616	1127
UBE2V1	2217	-1021
VRK3	402	-1398

---

---

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

MyD88:MAL(TIRAP) cascade initiated on plasma membrane

metric	value
setSize	71
pMANOVA	1.47e-06
p.adjustMANOVA	3.35e-05
s.dist	0.356
s.RNA	0.356
s.meth	-0.00759
p.RNA	2.3e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4180	-6586
IRAK3	4111	-6295
TLR1	4160	-6127
RPS6KA1	3425	-6629
APP	4212	-5300
NKIRAS2	4311	-5039
FBXW11	2542	-6747
MAPKAPK3	3709	-4540
MAP2K4	2923	-5363
MAPK14	4264	-3529
PELI3	3387	-4323
TNIP2	2191	-5726
TIRAP	2227	-5182
MAP2K3	4020	-2657
DUSP6	1572	-6763
PELI1	2722	-3839
MAPK3	4187	-2448
MEF2A	3577	-2822
PELI2	3658	-2561
ECSIT	1866	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
ATF1	2271	-2565
BTRC	-1491	-2427
CHUK	3527	1343
CREB1	-423	-672
CUL1	-4385	-5146
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
ECSIT	1866	-4938
FBXW11	2542	-6747
FOS	2486	2149
HMGB1	-66	-1263
IKBKB	-1620	-3894
IRAK2	-3415	-1457
IRAK3	4111	-6295
JUN	1372	69
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
RELA	-541	2085
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SIGIRR	-3945	290
SKP1	1561	-2290
SOCS1	1346	-2999
TAB2	2991	1892
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR6	4103	-802
TNIP2	2191	-5726
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2N	616	1127
UBE2V1	2217	-1021
VRK3	402	-1398

---

---

Toll Like Receptor 2 (TLR2) Cascade

Toll Like Receptor 2 (TLR2) Cascade

metric	value
setSize	71
pMANOVA	1.47e-06
p.adjustMANOVA	3.35e-05
s.dist	0.356
s.RNA	0.356
s.meth	-0.00759
p.RNA	2.3e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4180	-6586
IRAK3	4111	-6295
TLR1	4160	-6127
RPS6KA1	3425	-6629
APP	4212	-5300
NKIRAS2	4311	-5039
FBXW11	2542	-6747
MAPKAPK3	3709	-4540
MAP2K4	2923	-5363
MAPK14	4264	-3529
PELI3	3387	-4323
TNIP2	2191	-5726
TIRAP	2227	-5182
MAP2K3	4020	-2657
DUSP6	1572	-6763
PELI1	2722	-3839
MAPK3	4187	-2448
MEF2A	3577	-2822
PELI2	3658	-2561
ECSIT	1866	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
ATF1	2271	-2565
BTRC	-1491	-2427
CHUK	3527	1343
CREB1	-423	-672
CUL1	-4385	-5146
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
ECSIT	1866	-4938
FBXW11	2542	-6747
FOS	2486	2149
HMGB1	-66	-1263
IKBKB	-1620	-3894
IRAK2	-3415	-1457
IRAK3	4111	-6295
JUN	1372	69
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
RELA	-541	2085
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SIGIRR	-3945	290
SKP1	1561	-2290
SOCS1	1346	-2999
TAB2	2991	1892
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR6	4103	-802
TNIP2	2191	-5726
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2N	616	1127
UBE2V1	2217	-1021
VRK3	402	-1398

---

---

Toll Like Receptor TLR1:TLR2 Cascade

Toll Like Receptor TLR1:TLR2 Cascade

metric	value
setSize	71
pMANOVA	1.47e-06
p.adjustMANOVA	3.35e-05
s.dist	0.356
s.RNA	0.356
s.meth	-0.00759
p.RNA	2.3e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4180	-6586
IRAK3	4111	-6295
TLR1	4160	-6127
RPS6KA1	3425	-6629
APP	4212	-5300
NKIRAS2	4311	-5039
FBXW11	2542	-6747
MAPKAPK3	3709	-4540
MAP2K4	2923	-5363
MAPK14	4264	-3529
PELI3	3387	-4323
TNIP2	2191	-5726
TIRAP	2227	-5182
MAP2K3	4020	-2657
DUSP6	1572	-6763
PELI1	2722	-3839
MAPK3	4187	-2448
MEF2A	3577	-2822
PELI2	3658	-2561
ECSIT	1866	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
ATF1	2271	-2565
BTRC	-1491	-2427
CHUK	3527	1343
CREB1	-423	-672
CUL1	-4385	-5146
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
ECSIT	1866	-4938
FBXW11	2542	-6747
FOS	2486	2149
HMGB1	-66	-1263
IKBKB	-1620	-3894
IRAK2	-3415	-1457
IRAK3	4111	-6295
JUN	1372	69
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
RELA	-541	2085
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SIGIRR	-3945	290
SKP1	1561	-2290
SOCS1	1346	-2999
TAB2	2991	1892
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR6	4103	-802
TNIP2	2191	-5726
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2N	616	1127
UBE2V1	2217	-1021
VRK3	402	-1398

---

---

Toll Like Receptor TLR6:TLR2 Cascade

Toll Like Receptor TLR6:TLR2 Cascade

metric	value
setSize	71
pMANOVA	1.47e-06
p.adjustMANOVA	3.35e-05
s.dist	0.356
s.RNA	0.356
s.meth	-0.00759
p.RNA	2.3e-07
p.meth	0.912

Top 20 genes

Gene	RNA	meth
TLR2	4180	-6586
IRAK3	4111	-6295
TLR1	4160	-6127
RPS6KA1	3425	-6629
APP	4212	-5300
NKIRAS2	4311	-5039
FBXW11	2542	-6747
MAPKAPK3	3709	-4540
MAP2K4	2923	-5363
MAPK14	4264	-3529
PELI3	3387	-4323
TNIP2	2191	-5726
TIRAP	2227	-5182
MAP2K3	4020	-2657
DUSP6	1572	-6763
PELI1	2722	-3839
MAPK3	4187	-2448
MEF2A	3577	-2822
PELI2	3658	-2561
ECSIT	1866	-4938

Click HERE to show all gene set members

All member genes

	RNA	meth
APP	4212	-5300
ATF1	2271	-2565
BTRC	-1491	-2427
CHUK	3527	1343
CREB1	-423	-672
CUL1	-4385	-5146
DUSP3	4323	-1798
DUSP4	-2005	-3176
DUSP6	1572	-6763
DUSP7	-965	-1322
ECSIT	1866	-4938
FBXW11	2542	-6747
FOS	2486	2149
HMGB1	-66	-1263
IKBKB	-1620	-3894
IRAK2	-3415	-1457
IRAK3	4111	-6295
JUN	1372	69
MAP2K1	4120	-698
MAP2K3	4020	-2657
MAP2K4	2923	-5363
MAP2K6	4145	-1130
MAP2K7	509	-3915
MAP3K1	1953	-176
MAP3K7	780	-2089
MAP3K8	2531	1442
MAPK1	3257	1865
MAPK14	4264	-3529
MAPK3	4187	-2448
MAPK7	-388	-1630
MAPK8	-3380	6
MAPK9	-2306	872
MAPKAPK2	1470	2012
MAPKAPK3	3709	-4540
MEF2A	3577	-2822
MYD88	3613	-1927
NFKB2	-279	388
NFKBIA	2855	1159
NFKBIB	-27	-3368
NKIRAS1	122	-3490
NKIRAS2	4311	-5039
NOD1	-4838	-5170
NOD2	3786	1528
PELI1	2722	-3839
PELI2	3658	-2561
PELI3	3387	-4323
PPP2CA	3740	300
PPP2CB	3404	1797
PPP2R1B	-84	-2554
PPP2R5D	777	-4349
RELA	-541	2085
RPS27A	-2186	-2138
RPS6KA1	3425	-6629
RPS6KA2	1035	-1784
RPS6KA5	-4480	-514
SIGIRR	-3945	290
SKP1	1561	-2290
SOCS1	1346	-2999
TAB2	2991	1892
TIRAP	2227	-5182
TLR1	4160	-6127
TLR2	4180	-6586
TLR6	4103	-802
TNIP2	2191	-5726
TRAF6	-81	-6118
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
UBE2N	616	1127
UBE2V1	2217	-1021
VRK3	402	-1398

---

---

Programmed Cell Death

Programmed Cell Death

metric	value
setSize	134
pMANOVA	1.59e-06
p.adjustMANOVA	3.55e-05
s.dist	0.255
s.RNA	0.251
s.meth	0.0459
p.RNA	5.94e-07
p.meth	0.36

Top 20 genes

Gene	RNA	meth
MAPK1	3257	1865
BCL2L11	3144	1781
YWHAB	2609	2125
TNFRSF10B	3810	1433
PSMA7	3060	1752
BCL2L1	4028	1306
PSMD1	3121	1660
PSME3	3757	1116
PSMD12	2688	1314
PSMB2	1441	2355
PSMD13	2383	1328
PSMA2	2087	1205
PRKCD	4146	584
BID	2427	844
PTK2	1637	920
CARD8	1766	794
YWHAZ	2220	541
PLEC	1721	385
CFLAR	3336	197
UBA52	344	752

Click HERE to show all gene set members

All member genes

	RNA	meth
ACIN1	268	-1699
ADD1	2270	-89
AKT1	1248	-1942
AKT2	108	-141
APAF1	4182	-2104
APC	1087	-4775
APPL1	109	28
ARHGAP10	-3063	2322
AVEN	-2718	1579
BAD	2952	-1382
BAK1	-105	-4022
BAX	2386	-3623
BBC3	-2642	-3845
BCL2	-1339	2361
BCL2L1	4028	1306
BCL2L11	3144	1781
BID	2427	844
BIRC2	1750	-1862
BIRC3	-4025	-2320
BMF	1590	-6386
C1QBP	-287	-2507
CARD8	1766	794
CASP3	-160	-2764
CASP6	-862	-4898
CASP7	15	-842
CASP8	-4381	387
CASP9	3414	-234
CDKN2A	-1623	-4511
CFLAR	3336	197
CLSPN	1301	-1524
CTNNB1	2647	-1691
CYCS	-386	-3927
DAPK2	3159	-2374
DAPK3	1666	-4978
DBNL	3466	-3713
DFFA	1129	-3179
DFFB	-2134	-4631
DIABLO	-2018	-5548
DNM1L	985	-5217
DYNLL1	2413	-3319
DYNLL2	-1200	214
E2F1	2654	-1005
FADD	2255	-6328
FAS	1270	-5824
FNTA	-1750	1499
HMGB1	-66	-1263
HMGB2	3949	-5133
KPNA1	409	-2889
KPNB1	799	-2176
LMNA	1334	-6474
LMNB1	4362	-942
MAPK1	3257	1865
MAPK3	4187	-2448
MAPK8	-3380	6
MAPT	-1660	2342
MLKL	3100	-4557
NMT1	1591	-3001
OMA1	964	-5732
OPA1	871	-4730
PAK2	3694	-3961
PLEC	1721	385
PMAIP1	-4153	-2202
PPP1R13B	-4370	1874
PPP3CC	-4723	1250
PPP3R1	3702	-3276
PRKCD	4146	584
PRKCQ	-4731	1372
PSMA1	3157	-1782
PSMA2	2087	1205
PSMA3	-1628	-2824
PSMA5	-1904	592
PSMA6	2374	-1838
PSMA7	3060	1752
PSMB1	1146	-1179
PSMB10	-1777	-4718
PSMB2	1441	2355
PSMB3	3113	-2678
PSMB5	3671	-4604
PSMB6	2909	-3576
PSMB7	3871	-2038
PSMB8	-922	1189
PSMB9	-4328	-1453
PSMC1	3011	-5705
PSMC3	637	-4615
PSMC4	-3227	1003
PSMC5	-300	-3263
PSMC6	2783	-5508
PSMD1	3121	1660
PSMD11	2552	-2152
PSMD12	2688	1314
PSMD13	2383	1328
PSMD14	867	-2484
PSMD2	3230	-85
PSMD3	1722	-4331
PSMD4	3846	-4683
PSMD6	3475	-5488
PSMD7	2396	7
PSMD8	2301	-3290
PSMD9	3373	-2041
PSME1	-3644	-2343
PSME2	-3788	-2364
PSME3	3757	1116
PSME4	-1880	-3380
PSMF1	2794	-4867
PTK2	1637	920
RIPK3	1514	-370
ROCK1	3215	-985
RPS27A	-2186	-2138
SATB1	-2483	-1979
SFN	478	-5994
SPTAN1	-4369	-1250
STAT3	3649	-3606
STK24	2615	-1640
TFDP1	3847	-1587
TFDP2	-4878	-4793
TICAM1	2598	-2136
TJP2	1474	-67
TNFRSF10A	559	-3935
TNFRSF10B	3810	1433
TNFSF10	931	-2143
TP53	-4078	-739
TP53BP2	2173	-5830
TRADD	-173	-1481
TRAF2	-4465	-1442
UBA52	344	752
UBB	2801	-1321
UBC	1599	-2568
VIM	4364	-2247
YWHAB	2609	2125
YWHAE	4144	-4168
YWHAG	4313	-5545
YWHAH	3918	-2902
YWHAQ	-2419	-2908
YWHAZ	2220	541

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0                                      
##  [2] GGally_2.0.0                                       
##  [3] ggplot2_3.3.2                                      
##  [4] reshape2_1.4.4                                     
##  [5] gtools_3.8.2                                       
##  [6] tibble_3.0.1                                       
##  [7] dplyr_1.0.0                                        
##  [8] echarts4r_0.3.2                                    
##  [9] mitch_1.0.6                                        
## [10] FlowSorted.Blood.EPIC_1.6.1                        
## [11] ExperimentHub_1.14.0                               
## [12] AnnotationHub_2.20.0                               
## [13] BiocFileCache_1.12.0                               
## [14] dbplyr_1.4.4                                       
## [15] nlme_3.1-148                                       
## [16] quadprog_1.5-8                                     
## [17] genefilter_1.70.0                                  
## [18] topconfects_1.4.0                                  
## [19] gplots_3.0.3                                       
## [20] beeswarm_0.2.3                                     
## [21] IlluminaHumanMethylationEPICmanifest_0.3.0         
## [22] IlluminaHumanMethylationEPICanno.ilm10b2.hg19_0.6.0
## [23] limma_3.44.3                                       
## [24] missMethyl_1.22.0                                  
## [25] IlluminaHumanMethylationEPICanno.ilm10b4.hg19_0.6.0
## [26] IlluminaHumanMethylation450kanno.ilmn12.hg19_0.6.0 
## [27] minfi_1.34.0                                       
## [28] bumphunter_1.30.0                                  
## [29] locfit_1.5-9.4                                     
## [30] iterators_1.0.12                                   
## [31] foreach_1.5.0                                      
## [32] Biostrings_2.56.0                                  
## [33] XVector_0.28.0                                     
## [34] SummarizedExperiment_1.18.1                        
## [35] DelayedArray_0.14.0                                
## [36] matrixStats_0.56.0                                 
## [37] Biobase_2.48.0                                     
## [38] GenomicRanges_1.40.0                               
## [39] GenomeInfoDb_1.24.2                                
## [40] IRanges_2.22.2                                     
## [41] S4Vectors_0.26.1                                   
## [42] BiocGenerics_0.34.0                                
## 
## loaded via a namespace (and not attached):
##   [1] backports_1.1.8               plyr_1.8.6                   
##   [3] splines_4.0.2                 BiocParallel_1.22.0          
##   [5] digest_0.6.25                 htmltools_0.5.0              
##   [7] gdata_2.18.0                  magrittr_1.5                 
##   [9] memoise_1.1.0                 readr_1.3.1                  
##  [11] annotate_1.66.0               askpass_1.1                  
##  [13] siggenes_1.62.0               prettyunits_1.1.1            
##  [15] colorspace_1.4-1              blob_1.2.1                   
##  [17] rappdirs_0.3.1                xfun_0.15                    
##  [19] jsonlite_1.7.0                crayon_1.3.4                 
##  [21] RCurl_1.98-1.2                GEOquery_2.56.0              
##  [23] survival_3.2-3                glue_1.4.1                   
##  [25] gtable_0.3.0                  zlibbioc_1.34.0              
##  [27] Rhdf5lib_1.10.0               HDF5Array_1.16.1             
##  [29] scales_1.1.1                  DBI_1.1.0                    
##  [31] rngtools_1.5                  Rcpp_1.0.4.6                 
##  [33] xtable_1.8-4                  progress_1.2.2               
##  [35] bit_1.1-15.2                  mclust_5.4.6                 
##  [37] preprocessCore_1.50.0         htmlwidgets_1.5.1            
##  [39] httr_1.4.1                    RColorBrewer_1.1-2           
##  [41] ellipsis_0.3.1                farver_2.0.3                 
##  [43] pkgconfig_2.0.3               reshape_0.8.8                
##  [45] XML_3.99-0.3                  labeling_0.3                 
##  [47] tidyselect_1.1.0              rlang_0.4.6                  
##  [49] later_1.1.0.1                 AnnotationDbi_1.50.1         
##  [51] pbmcapply_1.5.0               munsell_0.5.0                
##  [53] BiocVersion_3.11.1            tools_4.0.2                  
##  [55] generics_0.0.2                RSQLite_2.2.0                
##  [57] evaluate_0.14                 stringr_1.4.0                
##  [59] fastmap_1.0.1                 yaml_2.2.1                   
##  [61] knitr_1.29                    org.Hs.eg.db_3.11.4          
##  [63] bit64_0.9-7                   beanplot_1.2                 
##  [65] caTools_1.18.0                scrime_1.3.5                 
##  [67] purrr_0.3.4                   doRNG_1.8.2                  
##  [69] mime_0.9                      nor1mix_1.3-0                
##  [71] xml2_1.3.2                    biomaRt_2.44.1               
##  [73] compiler_4.0.2                curl_4.3                     
##  [75] interactiveDisplayBase_1.26.3 testthat_2.3.2               
##  [77] statmod_1.4.34                stringi_1.4.6                
##  [79] highr_0.8                     desc_1.2.0                   
##  [81] GenomicFeatures_1.40.0        lattice_0.20-41              
##  [83] Matrix_1.2-18                 multtest_2.44.0              
##  [85] vctrs_0.3.1                   pillar_1.4.4                 
##  [87] lifecycle_0.2.0               BiocManager_1.30.10          
##  [89] data.table_1.12.8             bitops_1.0-6                 
##  [91] httpuv_1.5.4                  rtracklayer_1.48.0           
##  [93] R6_2.4.1                      promises_1.1.1               
##  [95] gridExtra_2.3                 KernSmooth_2.23-17           
##  [97] codetools_0.2-16              MASS_7.3-51.6                
##  [99] assertthat_0.2.1              rhdf5_2.32.1                 
## [101] rprojroot_1.3-2               openssl_1.4.2                
## [103] withr_2.2.0                   GenomicAlignments_1.24.0     
## [105] Rsamtools_2.4.0               GenomeInfoDbData_1.2.3       
## [107] hms_0.5.3                     grid_4.0.2                   
## [109] tidyr_1.1.0                   base64_2.0                   
## [111] rmarkdown_2.3                 DelayedMatrixStats_1.10.0    
## [113] illuminaio_0.30.0             shiny_1.5.0

END of report