date generated: 2021-04-21

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##            t0_v_pod     pod_crp     t0_crp
## A1BG      2.6192564  0.23019048 -3.0045626
## A1BG-AS1  0.5230655  0.62211022 -0.6855588
## A1CF      0.5526173  0.68373998  0.3272035
## A2M      -3.3389616 -0.03980079  1.6308274
## A2M-AS1  -3.1580711 -0.04056761  1.0554888
## A2ML1    -0.3535245  0.91485083  1.0055621

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 21381
duplicated_genes_present 0
num_profile_genes_in_sets 8367
num_profile_genes_not_in_sets 13014

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1046
num_genesets_included 1362

Genes by sector
t0_v_pod pod_crp t0_crp Count
1 -1 -1 -1 4308
2 0 -1 -1 1
3 1 -1 -1 881
4 -1 0 -1 1
5 -1 1 -1 1429
6 1 1 -1 3429
7 1 1 0 1
8 -1 -1 1 3776
9 1 -1 1 873
10 -1 1 1 2503
11 1 1 1 4179
Number of significant gene sets (FDR<0.05)= 782

Gene sets by sector


Gene sets by sector
s.t0_v_pod s.pod_crp s.t0_crp Count
1 -1 -1 -1 74
2 1 -1 -1 95
3 1 1 -1 304
4 -1 -1 1 114
5 1 -1 1 69
6 -1 1 1 2
7 1 1 1 124

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 100 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.t0_v_pod s.pod_crp s.t0_crp p.t0_v_pod p.pod_crp p.t0_crp
IRAK4 deficiency (TLR2/4) 10 2.40e-06 1.46e-05 1.270 0.89900 0.8260 0.34000 8.36e-07 6.10e-06 6.24e-02
MyD88 deficiency (TLR2/4) 10 2.40e-06 1.46e-05 1.270 0.89900 0.8260 0.34000 8.36e-07 6.10e-06 6.24e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.90e-05 1.25e-04 1.030 0.78500 0.6420 0.19800 2.48e-06 1.18e-04 2.35e-01
alpha-linolenic acid (ALA) metabolism 12 2.90e-05 1.25e-04 1.030 0.78500 0.6420 0.19800 2.48e-06 1.18e-04 2.35e-01
Regulation of TLR by endogenous ligand 11 1.23e-04 4.52e-04 1.010 0.74300 0.6260 0.26900 1.95e-05 3.22e-04 1.22e-01
Translocation of ZAP-70 to Immunological synapse 24 2.63e-09 2.99e-08 0.994 -0.74300 -0.6600 -0.00808 2.86e-10 2.12e-08 9.45e-01
Peptide chain elongation 88 1.95e-48 2.41e-46 0.986 -0.28100 -0.7020 -0.63300 5.05e-06 4.04e-30 9.10e-25
Eukaryotic Translation Elongation 93 3.79e-51 1.03e-48 0.980 -0.27300 -0.7010 -0.62900 5.39e-06 1.34e-31 8.59e-26
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 6.64e-05 2.59e-04 0.965 0.67000 0.5760 -0.38900 1.19e-04 9.45e-04 2.56e-02
Selenocysteine synthesis 92 4.47e-45 3.31e-43 0.948 -0.29900 -0.6800 -0.59000 7.43e-07 1.63e-29 1.27e-22
Viral mRNA Translation 88 4.24e-45 3.31e-43 0.945 -0.26200 -0.6790 -0.60200 2.13e-05 2.75e-28 1.45e-22
Eukaryotic Translation Termination 92 5.58e-46 5.43e-44 0.936 -0.26500 -0.6740 -0.59300 1.13e-05 4.40e-29 7.60e-23
Hyaluronan uptake and degradation 10 4.89e-04 1.46e-03 0.918 0.72900 0.5140 -0.21700 6.53e-05 4.89e-03 2.34e-01
Formation of a pool of free 40S subunits 100 3.12e-52 1.06e-49 0.914 -0.20800 -0.6770 -0.57700 3.27e-04 1.03e-31 1.85e-23
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.69e-43 1.83e-41 0.890 -0.24400 -0.6530 -0.55300 4.23e-05 6.26e-28 1.92e-20
Unwinding of DNA 12 8.24e-04 2.33e-03 0.886 -0.63700 -0.6140 -0.05120 1.33e-04 2.29e-04 7.59e-01
Uptake and function of anthrax toxins 10 9.39e-04 2.60e-03 0.850 0.70400 0.4330 -0.20000 1.17e-04 1.78e-02 2.74e-01
MET activates RAP1 and RAC1 10 4.32e-03 9.68e-03 0.833 0.53000 0.5150 0.38500 3.71e-03 4.84e-03 3.52e-02
VLDLR internalisation and degradation 11 3.50e-04 1.12e-03 0.830 0.46800 0.4840 -0.48600 7.18e-03 5.47e-03 5.27e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.74e-41 3.72e-39 0.827 -0.22200 -0.6280 -0.49000 1.28e-04 1.65e-27 2.35e-17
L13a-mediated translational silencing of Ceruloplasmin expression 110 7.42e-50 1.26e-47 0.812 -0.14300 -0.6210 -0.50300 9.49e-03 1.83e-29 7.74e-20
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.02e-48 1.38e-46 0.800 -0.14700 -0.6190 -0.48600 7.38e-03 1.70e-29 9.15e-19
WNT5A-dependent internalization of FZD4 13 1.26e-04 4.61e-04 0.798 0.44900 0.4250 -0.50500 5.07e-03 8.03e-03 1.61e-03
Advanced glycosylation endproduct receptor signaling 12 1.38e-03 3.59e-03 0.798 0.65000 0.4560 -0.07970 9.71e-05 6.19e-03 6.33e-01
Gap junction trafficking 13 7.39e-04 2.12e-03 0.781 0.56400 0.4550 -0.29200 4.32e-04 4.48e-03 6.83e-02
PD-1 signaling 28 9.24e-07 6.32e-06 0.781 -0.57900 -0.5240 0.00712 1.13e-07 1.55e-06 9.48e-01
RNA Polymerase I Promoter Opening 19 4.47e-08 3.90e-07 0.779 0.61600 0.1980 -0.43400 3.31e-06 1.35e-01 1.06e-03
Activation of the pre-replicative complex 32 2.09e-08 1.96e-07 0.771 -0.48200 -0.5790 0.16600 2.37e-06 1.45e-08 1.05e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.58e-02 2.99e-02 0.762 0.52800 0.5490 0.01380 3.86e-03 2.64e-03 9.40e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.07e-23 9.95e-22 0.759 -0.08310 -0.6120 -0.44100 3.05e-01 3.87e-14 5.15e-08
Retrograde neurotrophin signalling 12 1.14e-03 3.10e-03 0.757 0.56600 0.3780 -0.33000 6.80e-04 2.35e-02 4.76e-02
DNA strand elongation 32 2.89e-07 2.15e-06 0.751 -0.52200 -0.5350 0.07190 3.22e-07 1.59e-07 4.82e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.49e-38 8.47e-37 0.750 -0.19500 -0.5650 -0.45300 3.16e-04 1.92e-25 6.13e-17
Nonsense-Mediated Decay (NMD) 114 1.49e-38 8.47e-37 0.750 -0.19500 -0.5650 -0.45300 3.16e-04 1.92e-25 6.13e-17
Cap-dependent Translation Initiation 118 6.71e-46 5.71e-44 0.748 -0.13200 -0.5810 -0.45300 1.35e-02 1.02e-27 1.90e-17
Eukaryotic Translation Initiation 118 6.71e-46 5.71e-44 0.748 -0.13200 -0.5810 -0.45300 1.35e-02 1.02e-27 1.90e-17
RHO GTPases Activate WASPs and WAVEs 35 1.74e-08 1.70e-07 0.739 0.60800 0.4190 -0.02530 4.76e-10 1.77e-05 7.96e-01
RHO GTPases Activate ROCKs 18 6.19e-04 1.80e-03 0.735 0.54100 0.4920 0.07540 7.03e-05 3.04e-04 5.80e-01
Signaling by Leptin 10 2.13e-03 5.22e-03 0.733 0.56500 0.2740 -0.37900 1.98e-03 1.34e-01 3.79e-02
RHO GTPases Activate NADPH Oxidases 21 3.51e-05 1.49e-04 0.732 0.55900 0.4260 -0.20500 9.31e-06 7.34e-04 1.04e-01
Selenoamino acid metabolism 114 4.37e-34 1.92e-32 0.731 -0.22800 -0.5520 -0.42000 2.52e-05 1.98e-24 8.73e-15
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.52e-47 1.60e-45 0.725 -0.30600 -0.5910 -0.28600 1.30e-12 9.56e-43 3.47e-11
Activation of ATR in response to replication stress 36 9.68e-09 1.03e-07 0.724 -0.45200 -0.5060 0.25300 2.73e-06 1.52e-07 8.50e-03
rRNA processing in the nucleus and cytosol 190 1.28e-49 1.94e-47 0.723 -0.30700 -0.5870 -0.28800 2.77e-13 1.77e-44 7.70e-12
DNA methylation 20 7.18e-08 5.96e-07 0.722 0.51700 0.1090 -0.49300 6.35e-05 3.98e-01 1.35e-04
Erythrocytes take up carbon dioxide and release oxygen 11 1.53e-04 5.41e-04 0.720 0.68000 0.2000 -0.13100 9.48e-05 2.51e-01 4.52e-01
O2/CO2 exchange in erythrocytes 11 1.53e-04 5.41e-04 0.720 0.68000 0.2000 -0.13100 9.48e-05 2.51e-01 4.52e-01
Dissolution of Fibrin Clot 12 8.61e-03 1.75e-02 0.715 0.56600 0.4360 0.01510 6.87e-04 8.84e-03 9.28e-01
Phosphorylation of CD3 and TCR zeta chains 27 1.58e-05 7.65e-05 0.714 -0.53700 -0.4720 -0.00537 1.39e-06 2.21e-05 9.62e-01
Detoxification of Reactive Oxygen Species 32 8.18e-07 5.74e-06 0.709 0.56100 0.4310 -0.04810 3.93e-08 2.44e-05 6.38e-01
Neutrophil degranulation 457 0.00e+00 0.00e+00 0.706 0.58700 0.3800 -0.09810 0.00e+00 3.14e-44 3.28e-04
ROS and RNS production in phagocytes 31 1.98e-07 1.50e-06 0.704 0.59700 0.3670 -0.05860 8.47e-09 3.98e-04 5.73e-01
Influenza Viral RNA Transcription and Replication 135 1.83e-37 9.58e-36 0.703 -0.22500 -0.5440 -0.38400 6.45e-06 8.94e-28 1.21e-14
SRP-dependent cotranslational protein targeting to membrane 111 5.60e-38 3.05e-36 0.702 -0.13400 -0.5590 -0.40400 1.48e-02 2.40e-24 1.86e-13
Platelet sensitization by LDL 16 1.92e-03 4.72e-03 0.697 0.55200 0.4180 0.07930 1.31e-04 3.83e-03 5.83e-01
Trafficking of GluR2-containing AMPA receptors 12 1.72e-03 4.33e-03 0.695 0.46900 0.2780 -0.43100 4.91e-03 9.50e-02 9.68e-03
Diseases associated with the TLR signaling cascade 23 1.43e-04 5.12e-04 0.694 0.53400 0.4410 0.03190 9.12e-06 2.47e-04 7.91e-01
Diseases of Immune System 23 1.43e-04 5.12e-04 0.694 0.53400 0.4410 0.03190 9.12e-06 2.47e-04 7.91e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 6.02e-03 1.27e-02 0.693 0.55500 0.3950 0.12400 5.28e-04 1.36e-02 4.40e-01
rRNA modification in the nucleus and cytosol 59 7.21e-12 1.21e-10 0.691 -0.39700 -0.5560 -0.09860 1.32e-07 1.39e-13 1.90e-01
Insulin receptor recycling 21 1.16e-04 4.31e-04 0.689 0.56800 0.3830 -0.06510 6.47e-06 2.36e-03 6.06e-01
Heme degradation 10 1.73e-02 3.23e-02 0.687 0.40100 0.5350 -0.15600 2.80e-02 3.41e-03 3.92e-01
p130Cas linkage to MAPK signaling for integrins 11 1.41e-04 5.09e-04 0.686 0.66600 0.1590 -0.04040 1.32e-04 3.60e-01 8.17e-01
rRNA processing 217 3.11e-50 6.05e-48 0.685 -0.28900 -0.5440 -0.29900 2.16e-13 1.51e-43 3.13e-14
Hyaluronan metabolism 13 3.96e-03 8.95e-03 0.682 0.51300 0.3690 -0.25800 1.37e-03 2.13e-02 1.08e-01
Lagging Strand Synthesis 20 4.15e-04 1.29e-03 0.680 -0.45200 -0.4870 0.14600 4.65e-04 1.61e-04 2.60e-01
Josephin domain DUBs 10 1.18e-03 3.16e-03 0.674 0.47000 0.0859 -0.47500 1.01e-02 6.38e-01 9.27e-03
Pre-NOTCH Processing in Golgi 18 2.86e-04 9.43e-04 0.673 0.41100 0.3990 -0.35400 2.57e-03 3.37e-03 9.41e-03
Translation initiation complex formation 58 4.84e-23 1.53e-21 0.666 -0.02010 -0.5410 -0.38800 7.92e-01 9.62e-13 3.15e-07
COPI-independent Golgi-to-ER retrograde traffic 33 5.17e-07 3.73e-06 0.661 0.56300 0.3410 0.05300 2.13e-08 6.93e-04 5.99e-01
Ribosomal scanning and start codon recognition 58 3.07e-22 9.23e-21 0.657 -0.02510 -0.5360 -0.37800 7.41e-01 1.54e-12 6.22e-07
Processive synthesis on the lagging strand 15 7.14e-03 1.48e-02 0.656 -0.43100 -0.4920 0.04780 3.86e-03 9.65e-04 7.48e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 6.82e-23 2.11e-21 0.654 -0.00808 -0.5250 -0.38900 9.15e-01 2.92e-12 2.27e-07
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.85e-03 6.68e-03 0.654 0.54900 0.3150 0.16100 3.74e-04 4.10e-02 2.96e-01
EPHB-mediated forward signaling 32 8.75e-06 4.57e-05 0.653 0.50400 0.3870 0.15200 8.17e-07 1.54e-04 1.36e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 3.69e-04 1.18e-03 0.648 -0.44500 -0.4700 0.03520 1.59e-04 6.79e-05 7.66e-01
Generation of second messenger molecules 38 3.21e-06 1.85e-05 0.647 -0.46400 -0.4500 -0.01160 7.22e-07 1.59e-06 9.01e-01
Mucopolysaccharidoses 11 2.02e-02 3.69e-02 0.643 0.45500 0.3730 -0.25900 9.00e-03 3.22e-02 1.36e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.46e-02 7.29e-02 0.635 0.47600 0.4200 -0.01530 6.29e-03 1.59e-02 9.30e-01
Nucleobase biosynthesis 13 1.72e-02 3.22e-02 0.632 -0.35600 -0.5070 -0.12100 2.63e-02 1.53e-03 4.49e-01
Transferrin endocytosis and recycling 26 1.31e-04 4.78e-04 0.629 0.50900 0.3670 -0.04370 7.03e-06 1.19e-03 7.00e-01
Pentose phosphate pathway 13 1.08e-02 2.13e-02 0.627 0.48800 0.3390 -0.20200 2.33e-03 3.43e-02 2.07e-01
PCNA-Dependent Long Patch Base Excision Repair 21 1.82e-03 4.57e-03 0.624 -0.42000 -0.4610 0.02740 8.64e-04 2.52e-04 8.28e-01
Telomere C-strand synthesis initiation 13 1.59e-02 2.99e-02 0.624 -0.36100 -0.5090 0.01130 2.43e-02 1.48e-03 9.44e-01
Telomere C-strand (Lagging Strand) Synthesis 34 1.41e-05 7.06e-05 0.622 -0.38700 -0.4860 0.02050 9.40e-05 9.35e-07 8.36e-01
Removal of the Flap Intermediate 14 1.53e-02 2.90e-02 0.619 -0.39900 -0.4640 0.09150 9.75e-03 2.63e-03 5.53e-01
Regulation of IFNG signaling 14 1.06e-02 2.11e-02 0.619 0.39600 0.3280 0.34500 1.03e-02 3.37e-02 2.56e-02
Signal transduction by L1 20 3.18e-03 7.37e-03 0.615 0.43800 0.4290 -0.04680 6.90e-04 8.86e-04 7.17e-01
Gap junction trafficking and regulation 15 6.95e-03 1.45e-02 0.615 0.41400 0.3800 -0.24900 5.54e-03 1.08e-02 9.44e-02
Influenza Infection 154 5.68e-35 2.76e-33 0.614 -0.18100 -0.4980 -0.31100 1.07e-04 1.37e-26 2.75e-11
Negative regulation of MET activity 18 1.61e-03 4.11e-03 0.610 0.52600 0.3100 -0.01640 1.12e-04 2.30e-02 9.04e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.04e-03 2.84e-03 0.610 0.47800 0.0954 -0.36600 4.12e-03 5.67e-01 2.80e-02
Diseases of hemostasis 12 1.04e-03 2.84e-03 0.610 0.47800 0.0954 -0.36600 4.12e-03 5.67e-01 2.80e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.98e-05 9.28e-05 0.610 0.47100 0.1830 -0.34100 1.32e-04 1.38e-01 5.58e-03
HDR through MMEJ (alt-NHEJ) 10 5.15e-02 8.26e-02 0.606 -0.42900 -0.3650 0.22500 1.88e-02 4.58e-02 2.19e-01
IRAK1 recruits IKK complex 10 2.29e-02 4.11e-02 0.605 0.53300 0.2630 -0.11400 3.52e-03 1.50e-01 5.31e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 2.29e-02 4.11e-02 0.605 0.53300 0.2630 -0.11400 3.52e-03 1.50e-01 5.31e-01
MAP2K and MAPK activation 34 1.76e-06 1.10e-05 0.605 0.51600 0.2920 -0.11600 1.87e-07 3.17e-03 2.43e-01
Cargo concentration in the ER 30 7.40e-06 3.97e-05 0.603 0.52000 0.2830 0.11400 8.05e-07 7.23e-03 2.80e-01
Budding and maturation of HIV virion 26 4.06e-05 1.67e-04 0.602 0.52500 0.2840 -0.07800 3.50e-06 1.23e-02 4.91e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.t0_v_pod s.pod_crp s.t0_crp p.t0_v_pod p.pod_crp p.t0_crp
IRAK4 deficiency (TLR2/4) 10 2.40e-06 1.46e-05 1.2700 0.899000 0.826000 0.340000 8.36e-07 6.10e-06 6.24e-02
MyD88 deficiency (TLR2/4) 10 2.40e-06 1.46e-05 1.2700 0.899000 0.826000 0.340000 8.36e-07 6.10e-06 6.24e-02
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.90e-05 1.25e-04 1.0300 0.785000 0.642000 0.198000 2.48e-06 1.18e-04 2.35e-01
alpha-linolenic acid (ALA) metabolism 12 2.90e-05 1.25e-04 1.0300 0.785000 0.642000 0.198000 2.48e-06 1.18e-04 2.35e-01
Regulation of TLR by endogenous ligand 11 1.23e-04 4.52e-04 1.0100 0.743000 0.626000 0.269000 1.95e-05 3.22e-04 1.22e-01
Translocation of ZAP-70 to Immunological synapse 24 2.63e-09 2.99e-08 0.9940 -0.743000 -0.660000 -0.008080 2.86e-10 2.12e-08 9.45e-01
Peptide chain elongation 88 1.95e-48 2.41e-46 0.9860 -0.281000 -0.702000 -0.633000 5.05e-06 4.04e-30 9.10e-25
Eukaryotic Translation Elongation 93 3.79e-51 1.03e-48 0.9800 -0.273000 -0.701000 -0.629000 5.39e-06 1.34e-31 8.59e-26
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 6.64e-05 2.59e-04 0.9650 0.670000 0.576000 -0.389000 1.19e-04 9.45e-04 2.56e-02
Selenocysteine synthesis 92 4.47e-45 3.31e-43 0.9480 -0.299000 -0.680000 -0.590000 7.43e-07 1.63e-29 1.27e-22
Viral mRNA Translation 88 4.24e-45 3.31e-43 0.9450 -0.262000 -0.679000 -0.602000 2.13e-05 2.75e-28 1.45e-22
Eukaryotic Translation Termination 92 5.58e-46 5.43e-44 0.9360 -0.265000 -0.674000 -0.593000 1.13e-05 4.40e-29 7.60e-23
Hyaluronan uptake and degradation 10 4.89e-04 1.46e-03 0.9180 0.729000 0.514000 -0.217000 6.53e-05 4.89e-03 2.34e-01
Formation of a pool of free 40S subunits 100 3.12e-52 1.06e-49 0.9140 -0.208000 -0.677000 -0.577000 3.27e-04 1.03e-31 1.85e-23
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 2.69e-43 1.83e-41 0.8900 -0.244000 -0.653000 -0.553000 4.23e-05 6.26e-28 1.92e-20
Unwinding of DNA 12 8.24e-04 2.33e-03 0.8860 -0.637000 -0.614000 -0.051200 1.33e-04 2.29e-04 7.59e-01
Uptake and function of anthrax toxins 10 9.39e-04 2.60e-03 0.8500 0.704000 0.433000 -0.200000 1.17e-04 1.78e-02 2.74e-01
MET activates RAP1 and RAC1 10 4.32e-03 9.68e-03 0.8330 0.530000 0.515000 0.385000 3.71e-03 4.84e-03 3.52e-02
VLDLR internalisation and degradation 11 3.50e-04 1.12e-03 0.8300 0.468000 0.484000 -0.486000 7.18e-03 5.47e-03 5.27e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 5.74e-41 3.72e-39 0.8270 -0.222000 -0.628000 -0.490000 1.28e-04 1.65e-27 2.35e-17
L13a-mediated translational silencing of Ceruloplasmin expression 110 7.42e-50 1.26e-47 0.8120 -0.143000 -0.621000 -0.503000 9.49e-03 1.83e-29 7.74e-20
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.02e-48 1.38e-46 0.8000 -0.147000 -0.619000 -0.486000 7.38e-03 1.70e-29 9.15e-19
WNT5A-dependent internalization of FZD4 13 1.26e-04 4.61e-04 0.7980 0.449000 0.425000 -0.505000 5.07e-03 8.03e-03 1.61e-03
Advanced glycosylation endproduct receptor signaling 12 1.38e-03 3.59e-03 0.7980 0.650000 0.456000 -0.079700 9.71e-05 6.19e-03 6.33e-01
Gap junction trafficking 13 7.39e-04 2.12e-03 0.7810 0.564000 0.455000 -0.292000 4.32e-04 4.48e-03 6.83e-02
PD-1 signaling 28 9.24e-07 6.32e-06 0.7810 -0.579000 -0.524000 0.007120 1.13e-07 1.55e-06 9.48e-01
RNA Polymerase I Promoter Opening 19 4.47e-08 3.90e-07 0.7790 0.616000 0.198000 -0.434000 3.31e-06 1.35e-01 1.06e-03
Activation of the pre-replicative complex 32 2.09e-08 1.96e-07 0.7710 -0.482000 -0.579000 0.166000 2.37e-06 1.45e-08 1.05e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 1.58e-02 2.99e-02 0.7620 0.528000 0.549000 0.013800 3.86e-03 2.64e-03 9.40e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 3.07e-23 9.95e-22 0.7590 -0.083100 -0.612000 -0.441000 3.05e-01 3.87e-14 5.15e-08
Retrograde neurotrophin signalling 12 1.14e-03 3.10e-03 0.7570 0.566000 0.378000 -0.330000 6.80e-04 2.35e-02 4.76e-02
DNA strand elongation 32 2.89e-07 2.15e-06 0.7510 -0.522000 -0.535000 0.071900 3.22e-07 1.59e-07 4.82e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.49e-38 8.47e-37 0.7500 -0.195000 -0.565000 -0.453000 3.16e-04 1.92e-25 6.13e-17
Nonsense-Mediated Decay (NMD) 114 1.49e-38 8.47e-37 0.7500 -0.195000 -0.565000 -0.453000 3.16e-04 1.92e-25 6.13e-17
Cap-dependent Translation Initiation 118 6.71e-46 5.71e-44 0.7480 -0.132000 -0.581000 -0.453000 1.35e-02 1.02e-27 1.90e-17
Eukaryotic Translation Initiation 118 6.71e-46 5.71e-44 0.7480 -0.132000 -0.581000 -0.453000 1.35e-02 1.02e-27 1.90e-17
RHO GTPases Activate WASPs and WAVEs 35 1.74e-08 1.70e-07 0.7390 0.608000 0.419000 -0.025300 4.76e-10 1.77e-05 7.96e-01
RHO GTPases Activate ROCKs 18 6.19e-04 1.80e-03 0.7350 0.541000 0.492000 0.075400 7.03e-05 3.04e-04 5.80e-01
Signaling by Leptin 10 2.13e-03 5.22e-03 0.7330 0.565000 0.274000 -0.379000 1.98e-03 1.34e-01 3.79e-02
RHO GTPases Activate NADPH Oxidases 21 3.51e-05 1.49e-04 0.7320 0.559000 0.426000 -0.205000 9.31e-06 7.34e-04 1.04e-01
Selenoamino acid metabolism 114 4.37e-34 1.92e-32 0.7310 -0.228000 -0.552000 -0.420000 2.52e-05 1.98e-24 8.73e-15
Major pathway of rRNA processing in the nucleolus and cytosol 180 1.52e-47 1.60e-45 0.7250 -0.306000 -0.591000 -0.286000 1.30e-12 9.56e-43 3.47e-11
Activation of ATR in response to replication stress 36 9.68e-09 1.03e-07 0.7240 -0.452000 -0.506000 0.253000 2.73e-06 1.52e-07 8.50e-03
rRNA processing in the nucleus and cytosol 190 1.28e-49 1.94e-47 0.7230 -0.307000 -0.587000 -0.288000 2.77e-13 1.77e-44 7.70e-12
DNA methylation 20 7.18e-08 5.96e-07 0.7220 0.517000 0.109000 -0.493000 6.35e-05 3.98e-01 1.35e-04
Erythrocytes take up carbon dioxide and release oxygen 11 1.53e-04 5.41e-04 0.7200 0.680000 0.200000 -0.131000 9.48e-05 2.51e-01 4.52e-01
O2/CO2 exchange in erythrocytes 11 1.53e-04 5.41e-04 0.7200 0.680000 0.200000 -0.131000 9.48e-05 2.51e-01 4.52e-01
Dissolution of Fibrin Clot 12 8.61e-03 1.75e-02 0.7150 0.566000 0.436000 0.015100 6.87e-04 8.84e-03 9.28e-01
Phosphorylation of CD3 and TCR zeta chains 27 1.58e-05 7.65e-05 0.7140 -0.537000 -0.472000 -0.005370 1.39e-06 2.21e-05 9.62e-01
Detoxification of Reactive Oxygen Species 32 8.18e-07 5.74e-06 0.7090 0.561000 0.431000 -0.048100 3.93e-08 2.44e-05 6.38e-01
Neutrophil degranulation 457 4.62e-105 6.29e-102 0.7060 0.587000 0.380000 -0.098100 1.73e-103 3.14e-44 3.28e-04
ROS and RNS production in phagocytes 31 1.98e-07 1.50e-06 0.7040 0.597000 0.367000 -0.058600 8.47e-09 3.98e-04 5.73e-01
Influenza Viral RNA Transcription and Replication 135 1.83e-37 9.58e-36 0.7030 -0.225000 -0.544000 -0.384000 6.45e-06 8.94e-28 1.21e-14
SRP-dependent cotranslational protein targeting to membrane 111 5.60e-38 3.05e-36 0.7020 -0.134000 -0.559000 -0.404000 1.48e-02 2.40e-24 1.86e-13
Platelet sensitization by LDL 16 1.92e-03 4.72e-03 0.6970 0.552000 0.418000 0.079300 1.31e-04 3.83e-03 5.83e-01
Trafficking of GluR2-containing AMPA receptors 12 1.72e-03 4.33e-03 0.6950 0.469000 0.278000 -0.431000 4.91e-03 9.50e-02 9.68e-03
Diseases associated with the TLR signaling cascade 23 1.43e-04 5.12e-04 0.6940 0.534000 0.441000 0.031900 9.12e-06 2.47e-04 7.91e-01
Diseases of Immune System 23 1.43e-04 5.12e-04 0.6940 0.534000 0.441000 0.031900 9.12e-06 2.47e-04 7.91e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 6.02e-03 1.27e-02 0.6930 0.555000 0.395000 0.124000 5.28e-04 1.36e-02 4.40e-01
rRNA modification in the nucleus and cytosol 59 7.21e-12 1.21e-10 0.6910 -0.397000 -0.556000 -0.098600 1.32e-07 1.39e-13 1.90e-01
Insulin receptor recycling 21 1.16e-04 4.31e-04 0.6890 0.568000 0.383000 -0.065100 6.47e-06 2.36e-03 6.06e-01
Heme degradation 10 1.73e-02 3.23e-02 0.6870 0.401000 0.535000 -0.156000 2.80e-02 3.41e-03 3.92e-01
p130Cas linkage to MAPK signaling for integrins 11 1.41e-04 5.09e-04 0.6860 0.666000 0.159000 -0.040400 1.32e-04 3.60e-01 8.17e-01
rRNA processing 217 3.11e-50 6.05e-48 0.6850 -0.289000 -0.544000 -0.299000 2.16e-13 1.51e-43 3.13e-14
Hyaluronan metabolism 13 3.96e-03 8.95e-03 0.6820 0.513000 0.369000 -0.258000 1.37e-03 2.13e-02 1.08e-01
Lagging Strand Synthesis 20 4.15e-04 1.29e-03 0.6800 -0.452000 -0.487000 0.146000 4.65e-04 1.61e-04 2.60e-01
Josephin domain DUBs 10 1.18e-03 3.16e-03 0.6740 0.470000 0.085900 -0.475000 1.01e-02 6.38e-01 9.27e-03
Pre-NOTCH Processing in Golgi 18 2.86e-04 9.43e-04 0.6730 0.411000 0.399000 -0.354000 2.57e-03 3.37e-03 9.41e-03
Translation initiation complex formation 58 4.84e-23 1.53e-21 0.6660 -0.020100 -0.541000 -0.388000 7.92e-01 9.62e-13 3.15e-07
COPI-independent Golgi-to-ER retrograde traffic 33 5.17e-07 3.73e-06 0.6610 0.563000 0.341000 0.053000 2.13e-08 6.93e-04 5.99e-01
Ribosomal scanning and start codon recognition 58 3.07e-22 9.23e-21 0.6570 -0.025100 -0.536000 -0.378000 7.41e-01 1.54e-12 6.22e-07
Processive synthesis on the lagging strand 15 7.14e-03 1.48e-02 0.6560 -0.431000 -0.492000 0.047800 3.86e-03 9.65e-04 7.48e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 6.82e-23 2.11e-21 0.6540 -0.008080 -0.525000 -0.389000 9.15e-01 2.92e-12 2.27e-07
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.85e-03 6.68e-03 0.6540 0.549000 0.315000 0.161000 3.74e-04 4.10e-02 2.96e-01
EPHB-mediated forward signaling 32 8.75e-06 4.57e-05 0.6530 0.504000 0.387000 0.152000 8.17e-07 1.54e-04 1.36e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 3.69e-04 1.18e-03 0.6480 -0.445000 -0.470000 0.035200 1.59e-04 6.79e-05 7.66e-01
Generation of second messenger molecules 38 3.21e-06 1.85e-05 0.6470 -0.464000 -0.450000 -0.011600 7.22e-07 1.59e-06 9.01e-01
Mucopolysaccharidoses 11 2.02e-02 3.69e-02 0.6430 0.455000 0.373000 -0.259000 9.00e-03 3.22e-02 1.36e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 4.46e-02 7.29e-02 0.6350 0.476000 0.420000 -0.015300 6.29e-03 1.59e-02 9.30e-01
Nucleobase biosynthesis 13 1.72e-02 3.22e-02 0.6320 -0.356000 -0.507000 -0.121000 2.63e-02 1.53e-03 4.49e-01
Transferrin endocytosis and recycling 26 1.31e-04 4.78e-04 0.6290 0.509000 0.367000 -0.043700 7.03e-06 1.19e-03 7.00e-01
Pentose phosphate pathway 13 1.08e-02 2.13e-02 0.6270 0.488000 0.339000 -0.202000 2.33e-03 3.43e-02 2.07e-01
PCNA-Dependent Long Patch Base Excision Repair 21 1.82e-03 4.57e-03 0.6240 -0.420000 -0.461000 0.027400 8.64e-04 2.52e-04 8.28e-01
Telomere C-strand synthesis initiation 13 1.59e-02 2.99e-02 0.6240 -0.361000 -0.509000 0.011300 2.43e-02 1.48e-03 9.44e-01
Telomere C-strand (Lagging Strand) Synthesis 34 1.41e-05 7.06e-05 0.6220 -0.387000 -0.486000 0.020500 9.40e-05 9.35e-07 8.36e-01
Removal of the Flap Intermediate 14 1.53e-02 2.90e-02 0.6190 -0.399000 -0.464000 0.091500 9.75e-03 2.63e-03 5.53e-01
Regulation of IFNG signaling 14 1.06e-02 2.11e-02 0.6190 0.396000 0.328000 0.345000 1.03e-02 3.37e-02 2.56e-02
Signal transduction by L1 20 3.18e-03 7.37e-03 0.6150 0.438000 0.429000 -0.046800 6.90e-04 8.86e-04 7.17e-01
Gap junction trafficking and regulation 15 6.95e-03 1.45e-02 0.6150 0.414000 0.380000 -0.249000 5.54e-03 1.08e-02 9.44e-02
Influenza Infection 154 5.68e-35 2.76e-33 0.6140 -0.181000 -0.498000 -0.311000 1.07e-04 1.37e-26 2.75e-11
Negative regulation of MET activity 18 1.61e-03 4.11e-03 0.6100 0.526000 0.310000 -0.016400 1.12e-04 2.30e-02 9.04e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.04e-03 2.84e-03 0.6100 0.478000 0.095400 -0.366000 4.12e-03 5.67e-01 2.80e-02
Diseases of hemostasis 12 1.04e-03 2.84e-03 0.6100 0.478000 0.095400 -0.366000 4.12e-03 5.67e-01 2.80e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.98e-05 9.28e-05 0.6100 0.471000 0.183000 -0.341000 1.32e-04 1.38e-01 5.58e-03
HDR through MMEJ (alt-NHEJ) 10 5.15e-02 8.26e-02 0.6060 -0.429000 -0.365000 0.225000 1.88e-02 4.58e-02 2.19e-01
IRAK1 recruits IKK complex 10 2.29e-02 4.11e-02 0.6050 0.533000 0.263000 -0.114000 3.52e-03 1.50e-01 5.31e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 2.29e-02 4.11e-02 0.6050 0.533000 0.263000 -0.114000 3.52e-03 1.50e-01 5.31e-01
MAP2K and MAPK activation 34 1.76e-06 1.10e-05 0.6050 0.516000 0.292000 -0.116000 1.87e-07 3.17e-03 2.43e-01
Cargo concentration in the ER 30 7.40e-06 3.97e-05 0.6030 0.520000 0.283000 0.114000 8.05e-07 7.23e-03 2.80e-01
Budding and maturation of HIV virion 26 4.06e-05 1.67e-04 0.6020 0.525000 0.284000 -0.078000 3.50e-06 1.23e-02 4.91e-01
Presynaptic phase of homologous DNA pairing and strand exchange 39 4.72e-08 4.10e-07 0.6010 -0.329000 -0.261000 0.431000 3.83e-04 4.79e-03 3.24e-06
Homologous DNA Pairing and Strand Exchange 42 2.23e-08 2.07e-07 0.5990 -0.354000 -0.269000 0.402000 7.31e-05 2.60e-03 6.46e-06
Endosomal Sorting Complex Required For Transport (ESCRT) 29 1.88e-05 8.91e-05 0.5980 0.519000 0.290000 -0.057300 1.28e-06 6.83e-03 5.93e-01
GP1b-IX-V activation signalling 10 2.89e-04 9.51e-04 0.5970 0.357000 -0.190000 -0.439000 5.07e-02 2.97e-01 1.61e-02
RHO GTPases activate IQGAPs 11 6.38e-02 9.86e-02 0.5960 0.434000 0.367000 0.180000 1.27e-02 3.50e-02 3.01e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.83e-04 1.70e-03 0.5950 0.581000 0.126000 -0.041700 4.97e-04 4.50e-01 8.03e-01
Spry regulation of FGF signaling 16 1.44e-03 3.73e-03 0.5890 0.475000 0.216000 -0.274000 1.01e-03 1.35e-01 5.73e-02
Activation of Matrix Metalloproteinases 22 2.51e-04 8.34e-04 0.5870 0.374000 0.257000 -0.372000 2.41e-03 3.69e-02 2.52e-03
Collagen degradation 28 1.05e-04 3.94e-04 0.5850 0.394000 0.347000 -0.259000 3.10e-04 1.47e-03 1.77e-02
InlB-mediated entry of Listeria monocytogenes into host cell 12 8.11e-03 1.66e-02 0.5820 0.525000 0.220000 -0.122000 1.64e-03 1.87e-01 4.63e-01
Signaling by high-kinase activity BRAF mutants 31 1.54e-05 7.53e-05 0.5760 0.498000 0.272000 -0.101000 1.59e-06 8.77e-03 3.29e-01
NF-kB is activated and signals survival 12 2.63e-03 6.29e-03 0.5760 0.264000 -0.039700 -0.511000 1.14e-01 8.12e-01 2.18e-03
AKT phosphorylates targets in the cytosol 14 1.43e-02 2.71e-02 0.5760 0.427000 0.298000 -0.245000 5.63e-03 5.38e-02 1.12e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 3.80e-04 1.21e-03 0.5730 0.513000 0.229000 -0.115000 7.17e-05 7.68e-02 3.74e-01
Neurodegenerative Diseases 20 3.80e-04 1.21e-03 0.5730 0.513000 0.229000 -0.115000 7.17e-05 7.68e-02 3.74e-01
Erythropoietin activates RAS 13 5.43e-02 8.65e-02 0.5730 0.423000 0.385000 0.017800 8.22e-03 1.61e-02 9.11e-01
EGFR downregulation 27 1.29e-06 8.42e-06 0.5720 0.460000 0.123000 -0.316000 3.48e-05 2.67e-01 4.44e-03
NEP/NS2 Interacts with the Cellular Export Machinery 32 2.16e-05 9.90e-05 0.5710 -0.321000 -0.405000 0.242000 1.66e-03 7.28e-05 1.79e-02
GAB1 signalosome 15 9.26e-04 2.57e-03 0.5700 0.471000 0.136000 -0.292000 1.59e-03 3.63e-01 5.05e-02
Interactions of Rev with host cellular proteins 37 6.53e-06 3.54e-05 0.5690 -0.326000 -0.430000 0.179000 5.92e-04 5.85e-06 6.01e-02
Establishment of Sister Chromatid Cohesion 11 7.01e-05 2.72e-04 0.5690 0.064700 -0.438000 0.358000 7.10e-01 1.20e-02 4.00e-02
Rev-mediated nuclear export of HIV RNA 35 2.30e-05 1.04e-04 0.5640 -0.334000 -0.424000 0.165000 6.31e-04 1.42e-05 9.09e-02
Signal regulatory protein family interactions 12 3.28e-02 5.64e-02 0.5640 0.409000 0.291000 -0.258000 1.43e-02 8.13e-02 1.22e-01
Leading Strand Synthesis 14 2.56e-02 4.50e-02 0.5630 -0.364000 -0.382000 0.197000 1.84e-02 1.34e-02 2.03e-01
Polymerase switching 14 2.56e-02 4.50e-02 0.5630 -0.364000 -0.382000 0.197000 1.84e-02 1.34e-02 2.03e-01
Incretin synthesis, secretion, and inactivation 10 5.29e-03 1.14e-02 0.5610 0.163000 -0.079600 0.531000 3.73e-01 6.63e-01 3.64e-03
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 5.29e-03 1.14e-02 0.5610 0.163000 -0.079600 0.531000 3.73e-01 6.63e-01 3.64e-03
Formation of ATP by chemiosmotic coupling 18 1.04e-03 2.85e-03 0.5600 0.427000 0.186000 -0.311000 1.71e-03 1.72e-01 2.21e-02
Regulation of FZD by ubiquitination 15 9.23e-04 2.57e-03 0.5580 -0.009250 -0.355000 -0.431000 9.51e-01 1.73e-02 3.89e-03
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 7.32e-02 1.11e-01 0.5580 0.443000 0.325000 -0.100000 1.10e-02 6.21e-02 5.65e-01
NS1 Mediated Effects on Host Pathways 40 1.37e-06 8.81e-06 0.5580 -0.305000 -0.375000 0.278000 8.43e-04 3.99e-05 2.38e-03
RHO GTPases activate PKNs 47 1.22e-07 9.67e-07 0.5570 0.480000 0.267000 -0.095900 1.24e-08 1.55e-03 2.55e-01
Vpr-mediated nuclear import of PICs 34 2.03e-05 9.47e-05 0.5570 -0.309000 -0.425000 0.186000 1.85e-03 1.81e-05 6.01e-02
Smooth Muscle Contraction 31 2.43e-06 1.47e-05 0.5570 0.494000 0.194000 -0.168000 1.95e-06 6.13e-02 1.04e-01
RHO GTPases activate PAKs 20 1.83e-03 4.57e-03 0.5560 0.484000 0.263000 0.074700 1.78e-04 4.20e-02 5.63e-01
FOXO-mediated transcription of cell death genes 16 3.93e-03 8.90e-03 0.5540 0.332000 0.195000 -0.398000 2.15e-02 1.77e-01 5.78e-03
Notch-HLH transcription pathway 28 2.29e-04 7.76e-04 0.5530 0.407000 0.290000 -0.237000 1.92e-04 7.91e-03 3.03e-02
Packaging Of Telomere Ends 20 8.09e-06 4.27e-05 0.5510 0.448000 0.021400 -0.321000 5.29e-04 8.68e-01 1.28e-02
Platelet Aggregation (Plug Formation) 28 2.94e-06 1.73e-05 0.5480 0.476000 0.143000 -0.232000 1.29e-05 1.92e-01 3.39e-02
Amyloid fiber formation 51 2.65e-12 4.57e-11 0.5480 0.482000 0.110000 -0.237000 2.59e-09 1.74e-01 3.38e-03
Chondroitin sulfate biosynthesis 12 2.95e-02 5.11e-02 0.5480 0.296000 0.321000 -0.331000 7.61e-02 5.45e-02 4.68e-02
Nuclear import of Rev protein 34 3.14e-05 1.34e-04 0.5470 -0.306000 -0.410000 0.195000 2.03e-03 3.47e-05 4.96e-02
The NLRP3 inflammasome 15 2.01e-02 3.68e-02 0.5470 0.457000 0.285000 0.095800 2.18e-03 5.62e-02 5.21e-01
Regulated proteolysis of p75NTR 11 1.03e-01 1.48e-01 0.5460 0.416000 0.349000 -0.058400 1.69e-02 4.53e-02 7.37e-01
Lysosome Vesicle Biogenesis 32 2.33e-04 7.82e-04 0.5440 0.404000 0.329000 -0.158000 7.55e-05 1.29e-03 1.22e-01
Response of Mtb to phagocytosis 22 3.94e-04 1.24e-03 0.5440 0.459000 0.205000 -0.209000 1.96e-04 9.59e-02 8.91e-02
Prolonged ERK activation events 13 4.64e-02 7.55e-02 0.5440 0.452000 0.303000 -0.009470 4.80e-03 5.82e-02 9.53e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 2.52e-03 6.05e-03 0.5420 0.446000 0.026800 0.307000 1.46e-02 8.83e-01 9.27e-02
Postmitotic nuclear pore complex (NPC) reformation 27 1.36e-04 4.94e-04 0.5400 -0.263000 -0.437000 0.178000 1.81e-02 8.37e-05 1.09e-01
CDC6 association with the ORC:origin complex 11 6.03e-03 1.27e-02 0.5400 -0.040600 -0.249000 0.478000 8.16e-01 1.52e-01 6.08e-03
SUMOylation of immune response proteins 11 6.90e-02 1.05e-01 0.5400 0.408000 0.290000 -0.203000 1.92e-02 9.56e-02 2.45e-01
Integrin signaling 22 1.89e-03 4.68e-03 0.5390 0.456000 0.266000 -0.108000 2.10e-04 3.06e-02 3.83e-01
Biotin transport and metabolism 11 7.44e-02 1.13e-01 0.5370 -0.439000 -0.279000 -0.135000 1.17e-02 1.09e-01 4.39e-01
Interactions of Vpr with host cellular proteins 37 1.41e-05 7.06e-05 0.5370 -0.285000 -0.436000 0.130000 2.71e-03 4.36e-06 1.72e-01
Recycling pathway of L1 26 1.32e-03 3.49e-03 0.5370 0.426000 0.302000 -0.123000 1.70e-04 7.62e-03 2.78e-01
ERKs are inactivated 13 4.42e-02 7.25e-02 0.5360 0.432000 0.289000 -0.129000 6.97e-03 7.08e-02 4.21e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.88e-05 2.35e-04 0.5360 -0.288000 -0.384000 0.238000 4.84e-03 1.73e-04 1.96e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 1.95e-02 3.57e-02 0.5330 0.281000 0.446000 -0.077300 5.99e-02 2.78e-03 6.04e-01
Signaling by RAF1 mutants 34 2.09e-05 9.64e-05 0.5320 0.471000 0.241000 -0.062800 2.03e-06 1.51e-02 5.26e-01
Metabolism of non-coding RNA 53 1.64e-08 1.62e-07 0.5300 -0.255000 -0.417000 0.204000 1.31e-03 1.49e-07 1.00e-02
snRNP Assembly 53 1.64e-08 1.62e-07 0.5300 -0.255000 -0.417000 0.204000 1.31e-03 1.49e-07 1.00e-02
Growth hormone receptor signaling 20 1.29e-02 2.49e-02 0.5290 0.421000 0.320000 -0.017100 1.13e-03 1.31e-02 8.94e-01
Extension of Telomeres 51 3.26e-06 1.88e-05 0.5280 -0.311000 -0.426000 -0.000978 1.21e-04 1.41e-07 9.90e-01
Pexophagy 11 8.95e-03 1.82e-02 0.5270 0.357000 0.024000 -0.388000 4.06e-02 8.91e-01 2.59e-02
activated TAK1 mediates p38 MAPK activation 19 6.14e-03 1.29e-02 0.5270 0.455000 0.259000 -0.061800 5.93e-04 5.07e-02 6.41e-01
Membrane binding and targetting of GAG proteins 13 1.79e-02 3.32e-02 0.5230 0.445000 0.193000 -0.193000 5.43e-03 2.27e-01 2.28e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 1.79e-02 3.32e-02 0.5230 0.445000 0.193000 -0.193000 5.43e-03 2.27e-01 2.28e-01
Platelet Adhesion to exposed collagen 13 6.39e-05 2.54e-04 0.5220 0.500000 -0.055100 -0.141000 1.80e-03 7.31e-01 3.77e-01
Translesion synthesis by REV1 16 2.71e-02 4.73e-02 0.5220 -0.294000 -0.431000 0.015600 4.15e-02 2.82e-03 9.14e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 3.00e-04 9.75e-04 0.5200 -0.309000 -0.361000 0.212000 2.93e-03 5.04e-04 4.06e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 3.00e-04 9.75e-04 0.5200 -0.309000 -0.361000 0.212000 2.93e-03 5.04e-04 4.06e-02
Purine ribonucleoside monophosphate biosynthesis 10 9.91e-02 1.43e-01 0.5200 -0.266000 -0.447000 0.012500 1.46e-01 1.44e-02 9.45e-01
Assembly Of The HIV Virion 15 1.07e-02 2.12e-02 0.5190 0.417000 0.192000 -0.241000 5.12e-03 1.98e-01 1.06e-01
Sema4D in semaphorin signaling 22 1.11e-02 2.19e-02 0.5180 0.379000 0.344000 -0.080400 2.09e-03 5.24e-03 5.14e-01
Diseases of DNA repair 10 1.83e-01 2.35e-01 0.5170 -0.366000 -0.365000 0.029300 4.52e-02 4.58e-02 8.72e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.15e-04 4.28e-04 0.5170 -0.285000 -0.376000 0.211000 4.58e-03 1.82e-04 3.60e-02
BBSome-mediated cargo-targeting to cilium 22 3.09e-04 1.00e-03 0.5170 -0.195000 -0.455000 0.147000 1.14e-01 2.19e-04 2.32e-01
Sema4D induced cell migration and growth-cone collapse 19 1.90e-02 3.49e-02 0.5150 0.375000 0.328000 -0.130000 4.64e-03 1.34e-02 3.26e-01
Polymerase switching on the C-strand of the telomere 26 3.79e-03 8.61e-03 0.5120 -0.305000 -0.411000 -0.003220 7.06e-03 2.82e-04 9.77e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 25 7.27e-04 2.09e-03 0.5110 0.431000 0.219000 -0.166000 1.88e-04 5.85e-02 1.51e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 1.15e-02 2.27e-02 0.5110 -0.158000 -0.222000 -0.433000 2.61e-01 1.13e-01 2.00e-03
Signaling by Erythropoietin 24 7.84e-03 1.61e-02 0.5080 0.377000 0.328000 -0.090700 1.38e-03 5.35e-03 4.42e-01
Glycogen breakdown (glycogenolysis) 13 5.71e-02 9.00e-02 0.5070 0.410000 0.262000 -0.142000 1.04e-02 1.01e-01 3.74e-01
tRNA processing in the mitochondrion 30 7.58e-05 2.93e-04 0.5070 -0.141000 -0.117000 -0.473000 1.82e-01 2.67e-01 7.26e-06
Transport of the SLBP independent Mature mRNA 35 6.42e-05 2.54e-04 0.5070 -0.270000 -0.353000 0.243000 5.64e-03 2.98e-04 1.27e-02
Transport of the SLBP Dependant Mature mRNA 36 2.65e-05 1.16e-04 0.5040 -0.246000 -0.358000 0.255000 1.07e-02 2.00e-04 8.17e-03
Glycogen synthesis 13 4.69e-03 1.04e-02 0.5030 0.404000 0.052500 -0.295000 1.17e-02 7.43e-01 6.54e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.13e-04 1.28e-03 0.5030 0.304000 -0.082800 -0.391000 3.50e-02 5.66e-01 6.71e-03
Infection with Mycobacterium tuberculosis 26 1.76e-04 6.11e-04 0.5030 0.449000 0.173000 -0.145000 7.40e-05 1.26e-01 2.01e-01
Cytosolic iron-sulfur cluster assembly 13 1.27e-02 2.46e-02 0.5020 -0.187000 -0.047900 -0.464000 2.43e-01 7.65e-01 3.79e-03
HDR through Single Strand Annealing (SSA) 37 2.24e-05 1.01e-04 0.5020 -0.278000 -0.221000 0.354000 3.44e-03 2.00e-02 1.92e-04
Late endosomal microautophagy 30 2.94e-04 9.60e-04 0.5010 0.423000 0.226000 -0.147000 6.12e-05 3.25e-02 1.64e-01
SHC1 events in EGFR signaling 12 9.14e-03 1.84e-02 0.5010 0.480000 0.119000 -0.081100 4.00e-03 4.76e-01 6.27e-01
Common Pathway of Fibrin Clot Formation 14 2.44e-02 4.34e-02 0.5000 0.335000 0.183000 -0.322000 2.99e-02 2.36e-01 3.68e-02
EPH-Ephrin signaling 78 8.26e-09 8.86e-08 0.4990 0.399000 0.281000 -0.105000 1.13e-09 1.79e-05 1.08e-01
tRNA processing in the nucleus 59 3.05e-07 2.24e-06 0.4990 -0.291000 -0.354000 0.197000 1.12e-04 2.52e-06 8.83e-03
Antimicrobial peptides 33 2.49e-08 2.28e-07 0.4980 0.459000 0.035000 -0.192000 5.09e-06 7.28e-01 5.66e-02
LDL clearance 17 2.95e-02 5.11e-02 0.4980 0.345000 0.301000 -0.196000 1.37e-02 3.17e-02 1.62e-01
Response to elevated platelet cytosolic Ca2+ 108 8.42e-19 2.16e-17 0.4980 0.453000 0.153000 -0.138000 3.81e-16 6.03e-03 1.29e-02
Diseases of carbohydrate metabolism 29 3.94e-04 1.24e-03 0.4980 0.333000 0.214000 -0.303000 1.93e-03 4.65e-02 4.80e-03
RHO GTPases activate CIT 18 4.34e-02 7.16e-02 0.4970 0.369000 0.314000 0.114000 6.79e-03 2.11e-02 4.02e-01
Platelet degranulation 104 3.96e-18 9.81e-17 0.4940 0.451000 0.147000 -0.136000 1.74e-15 9.52e-03 1.63e-02
Plasma lipoprotein clearance 28 5.36e-04 1.57e-03 0.4940 0.278000 0.224000 -0.341000 1.09e-02 4.05e-02 1.78e-03
Cytochrome c-mediated apoptotic response 13 6.90e-02 1.05e-01 0.4920 0.339000 0.235000 0.268000 3.44e-02 1.42e-01 9.47e-02
GRB2 events in EGFR signaling 11 7.83e-03 1.61e-02 0.4900 0.477000 0.070300 -0.084200 6.15e-03 6.87e-01 6.29e-01
Scavenging by Class A Receptors 11 1.89e-01 2.41e-01 0.4880 0.370000 0.309000 0.073900 3.36e-02 7.55e-02 6.71e-01
CD28 dependent PI3K/Akt signaling 22 1.21e-02 2.37e-02 0.4870 -0.296000 -0.259000 -0.287000 1.63e-02 3.51e-02 1.96e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 6.65e-03 1.39e-02 0.4860 0.454000 0.140000 -0.106000 2.34e-03 3.48e-01 4.79e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 8.22e-13 1.49e-11 0.4860 0.438000 0.201000 -0.059400 3.52e-13 8.84e-04 3.25e-01
Toll Like Receptor 2 (TLR2) Cascade 92 8.22e-13 1.49e-11 0.4860 0.438000 0.201000 -0.059400 3.52e-13 8.84e-04 3.25e-01
Toll Like Receptor TLR1:TLR2 Cascade 92 8.22e-13 1.49e-11 0.4860 0.438000 0.201000 -0.059400 3.52e-13 8.84e-04 3.25e-01
Toll Like Receptor TLR6:TLR2 Cascade 92 8.22e-13 1.49e-11 0.4860 0.438000 0.201000 -0.059400 3.52e-13 8.84e-04 3.25e-01
Mitochondrial tRNA aminoacylation 21 2.26e-02 4.06e-02 0.4860 -0.311000 -0.369000 0.057900 1.36e-02 3.44e-03 6.46e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 8.83e-02 1.30e-01 0.4850 -0.307000 -0.368000 0.080100 4.70e-02 1.72e-02 6.04e-01
RHO GTPases activate KTN1 11 1.63e-01 2.17e-01 0.4850 0.391000 0.281000 0.059900 2.47e-02 1.06e-01 7.31e-01
Resolution of Abasic Sites (AP sites) 37 1.55e-03 3.98e-03 0.4850 -0.348000 -0.327000 -0.085100 2.50e-04 5.79e-04 3.71e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 3.00e-05 1.29e-04 0.4840 0.302000 -0.080900 -0.370000 1.42e-02 5.11e-01 2.66e-03
COPI-mediated anterograde transport 78 6.29e-08 5.29e-07 0.4840 0.392000 0.278000 0.058700 2.10e-09 2.20e-05 3.70e-01
Butyrophilin (BTN) family interactions 10 1.15e-01 1.64e-01 0.4830 -0.423000 -0.217000 0.085500 2.04e-02 2.35e-01 6.40e-01
Antigen processing-Cross presentation 97 2.30e-10 2.99e-09 0.4810 0.401000 0.258000 0.064500 8.19e-12 1.13e-05 2.73e-01
Cleavage of the damaged purine 24 3.70e-05 1.55e-04 0.4810 0.352000 0.002720 -0.327000 2.80e-03 9.82e-01 5.51e-03
Depurination 24 3.70e-05 1.55e-04 0.4810 0.352000 0.002720 -0.327000 2.80e-03 9.82e-01 5.51e-03
Recognition and association of DNA glycosylase with site containing an affected purine 24 3.70e-05 1.55e-04 0.4810 0.352000 0.002720 -0.327000 2.80e-03 9.82e-01 5.51e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 2.64e-05 1.16e-04 0.4810 0.432000 0.199000 -0.069600 4.09e-06 3.37e-02 4.58e-01
Signaling by RAS mutants 38 2.64e-05 1.16e-04 0.4810 0.432000 0.199000 -0.069600 4.09e-06 3.37e-02 4.58e-01
Signaling by moderate kinase activity BRAF mutants 38 2.64e-05 1.16e-04 0.4810 0.432000 0.199000 -0.069600 4.09e-06 3.37e-02 4.58e-01
Signaling downstream of RAS mutants 38 2.64e-05 1.16e-04 0.4810 0.432000 0.199000 -0.069600 4.09e-06 3.37e-02 4.58e-01
Signal amplification 28 3.07e-04 9.97e-04 0.4800 0.440000 0.187000 0.049100 5.62e-05 8.70e-02 6.53e-01
Suppression of phagosomal maturation 12 3.56e-02 6.05e-02 0.4800 0.437000 0.163000 -0.111000 8.73e-03 3.28e-01 5.06e-01
HuR (ELAVL1) binds and stabilizes mRNA 10 9.41e-02 1.38e-01 0.4790 0.408000 0.189000 0.163000 2.53e-02 3.02e-01 3.71e-01
GPVI-mediated activation cascade 31 4.05e-03 9.12e-03 0.4780 0.329000 0.339000 -0.070700 1.52e-03 1.10e-03 4.96e-01
Translesion synthesis by POLI 17 3.42e-02 5.84e-02 0.4770 -0.261000 -0.395000 0.063700 6.24e-02 4.84e-03 6.50e-01
trans-Golgi Network Vesicle Budding 69 1.69e-06 1.06e-05 0.4770 0.371000 0.299000 -0.027800 1.01e-07 1.73e-05 6.89e-01
PKA activation in glucagon signalling 14 2.57e-02 4.52e-02 0.4760 0.345000 0.142000 -0.295000 2.53e-02 3.56e-01 5.63e-02
Early Phase of HIV Life Cycle 14 9.97e-03 1.99e-02 0.4760 -0.150000 -0.441000 0.095000 3.31e-01 4.25e-03 5.38e-01
Pyrimidine salvage 10 1.60e-01 2.13e-01 0.4750 0.345000 0.246000 -0.215000 5.90e-02 1.77e-01 2.39e-01
Cross-presentation of soluble exogenous antigens (endosomes) 47 1.36e-05 6.89e-05 0.4750 0.398000 0.225000 0.129000 2.35e-06 7.52e-03 1.26e-01
Interleukin-1 signaling 97 7.01e-13 1.36e-11 0.4740 0.431000 0.196000 -0.015200 2.20e-13 8.29e-04 7.95e-01
G-protein beta:gamma signalling 29 5.04e-03 1.09e-02 0.4730 0.375000 0.283000 -0.057300 4.69e-04 8.40e-03 5.93e-01
Post-translational protein phosphorylation 69 1.97e-06 1.22e-05 0.4730 0.344000 0.313000 -0.083200 7.45e-07 6.85e-06 2.32e-01
E2F mediated regulation of DNA replication 22 4.77e-04 1.43e-03 0.4710 -0.120000 -0.332000 0.311000 3.28e-01 7.07e-03 1.14e-02
Effects of PIP2 hydrolysis 24 7.93e-03 1.63e-02 0.4710 -0.307000 -0.227000 -0.275000 9.19e-03 5.39e-02 1.98e-02
p75NTR signals via NF-kB 15 5.30e-03 1.14e-02 0.4710 0.291000 -0.003890 -0.370000 5.07e-02 9.79e-01 1.32e-02
Regulation of expression of SLITs and ROBOs 159 2.70e-26 9.94e-25 0.4700 -0.041600 -0.344000 -0.318000 3.65e-01 7.32e-14 4.51e-12
Gastrin-CREB signalling pathway via PKC and MAPK 14 2.52e-02 4.45e-02 0.4700 0.408000 0.158000 -0.170000 8.16e-03 3.06e-01 2.70e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 8.83e-04 2.47e-03 0.4690 -0.243000 -0.121000 0.382000 3.17e-02 2.87e-01 7.36e-04
Processive synthesis on the C-strand of the telomere 19 2.87e-02 4.99e-02 0.4680 -0.255000 -0.393000 0.010100 5.44e-02 3.04e-03 9.39e-01
SUMOylation of DNA methylation proteins 16 1.84e-02 3.40e-02 0.4680 -0.040500 -0.190000 -0.426000 7.79e-01 1.89e-01 3.15e-03
Inflammasomes 20 1.21e-02 2.37e-02 0.4680 0.399000 0.212000 0.122000 1.99e-03 1.00e-01 3.47e-01
G1/S-Specific Transcription 29 2.77e-06 1.65e-05 0.4670 -0.084800 -0.421000 0.182000 4.29e-01 8.57e-05 9.00e-02
ADP signalling through P2Y purinoceptor 1 21 1.28e-02 2.48e-02 0.4660 0.406000 0.226000 0.036300 1.29e-03 7.35e-02 7.74e-01
Processing and activation of SUMO 10 1.87e-02 3.46e-02 0.4660 0.060600 -0.195000 0.418000 7.40e-01 2.85e-01 2.20e-02
CD22 mediated BCR regulation 59 2.18e-10 2.86e-09 0.4650 -0.135000 -0.432000 0.107000 7.25e-02 9.61e-09 1.55e-01
rRNA processing in the mitochondrion 27 2.98e-03 6.99e-03 0.4640 -0.156000 -0.231000 -0.371000 1.60e-01 3.76e-02 8.40e-04
Activated NOTCH1 Transmits Signal to the Nucleus 27 2.23e-03 5.43e-03 0.4630 0.268000 0.224000 -0.304000 1.61e-02 4.35e-02 6.26e-03
COPII-mediated vesicle transport 65 1.19e-06 7.85e-06 0.4620 0.389000 0.242000 0.061100 5.77e-08 7.57e-04 3.94e-01
ATF6 (ATF6-alpha) activates chaperones 12 7.43e-03 1.54e-02 0.4610 0.416000 0.051400 0.192000 1.26e-02 7.58e-01 2.49e-01
Glycogen storage diseases 13 5.98e-02 9.35e-02 0.4610 0.301000 0.169000 -0.305000 6.04e-02 2.92e-01 5.66e-02
Condensation of Prometaphase Chromosomes 11 2.16e-02 3.91e-02 0.4580 0.096300 -0.111000 0.434000 5.80e-01 5.25e-01 1.26e-02
SLBP independent Processing of Histone Pre-mRNAs 10 7.22e-02 1.10e-01 0.4580 -0.153000 -0.432000 0.002130 4.03e-01 1.81e-02 9.91e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 6.76e-03 1.41e-02 0.4560 0.385000 0.241000 0.039100 5.31e-04 3.05e-02 7.25e-01
Pre-NOTCH Transcription and Translation 49 4.25e-06 2.40e-05 0.4550 0.352000 0.170000 -0.234000 2.05e-05 4.00e-02 4.63e-03
Pre-NOTCH Expression and Processing 65 1.54e-07 1.19e-06 0.4550 0.348000 0.190000 -0.223000 1.26e-06 7.94e-03 1.83e-03
Metabolism of Angiotensinogen to Angiotensins 11 5.04e-02 8.10e-02 0.4540 0.392000 0.111000 -0.200000 2.44e-02 5.23e-01 2.50e-01
Signalling to ERKs 31 1.63e-03 4.14e-03 0.4540 0.397000 0.219000 0.019700 1.30e-04 3.47e-02 8.50e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 9.99e-03 2.00e-02 0.4530 0.275000 -0.016000 0.359000 9.85e-02 9.23e-01 3.13e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.68e-02 3.15e-02 0.4520 -0.082600 -0.441000 0.061000 6.35e-01 1.14e-02 7.26e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 5.47e-03 1.17e-02 0.4520 0.264000 0.167000 -0.327000 2.86e-02 1.65e-01 6.61e-03
Olfactory Signaling Pathway 57 9.32e-07 6.32e-06 0.4510 0.086100 0.191000 0.400000 2.61e-01 1.28e-02 1.76e-07
Frs2-mediated activation 11 1.70e-01 2.24e-01 0.4510 0.377000 0.233000 -0.082200 3.02e-02 1.82e-01 6.37e-01
Transcriptional regulation of granulopoiesis 46 8.13e-08 6.59e-07 0.4510 0.419000 0.096200 -0.135000 8.80e-07 2.59e-01 1.13e-01
Formation of apoptosome 11 1.20e-01 1.69e-01 0.4500 0.383000 0.192000 0.139000 2.79e-02 2.69e-01 4.25e-01
Regulation of the apoptosome activity 11 1.20e-01 1.69e-01 0.4500 0.383000 0.192000 0.139000 2.79e-02 2.69e-01 4.25e-01
Formation of the cornified envelope 21 2.21e-02 4.00e-02 0.4500 0.372000 0.231000 -0.107000 3.19e-03 6.74e-02 3.96e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 1.36e-03 3.57e-03 0.4500 0.367000 0.091300 -0.244000 2.88e-03 4.58e-01 4.74e-02
ER to Golgi Anterograde Transport 129 1.11e-11 1.82e-10 0.4500 0.371000 0.248000 0.059500 3.31e-13 1.20e-06 2.44e-01
ERK/MAPK targets 22 4.46e-03 9.94e-03 0.4490 0.407000 0.166000 -0.090000 9.43e-04 1.78e-01 4.65e-01
Gluconeogenesis 28 3.15e-03 7.33e-03 0.4490 0.242000 0.293000 -0.238000 2.68e-02 7.19e-03 2.91e-02
Translesion synthesis by POLK 17 5.02e-02 8.08e-02 0.4480 -0.240000 -0.372000 0.068300 8.61e-02 7.94e-03 6.26e-01
Glycogen metabolism 23 2.47e-03 5.94e-03 0.4470 0.357000 0.125000 -0.237000 3.01e-03 2.99e-01 4.87e-02
Inhibition of DNA recombination at telomere 35 1.30e-06 8.42e-06 0.4470 0.343000 0.002950 -0.287000 4.49e-04 9.76e-01 3.33e-03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 87 1.54e-11 2.44e-10 0.4450 0.408000 0.153000 -0.089600 4.64e-11 1.39e-02 1.49e-01
Golgi Associated Vesicle Biogenesis 55 5.90e-05 2.35e-04 0.4450 0.367000 0.251000 -0.001390 2.49e-06 1.29e-03 9.86e-01
Toll Like Receptor 4 (TLR4) Cascade 121 1.75e-13 3.56e-12 0.4440 0.398000 0.193000 -0.032900 3.68e-14 2.51e-04 5.31e-01
Alpha-protein kinase 1 signaling pathway 11 3.33e-03 7.68e-03 0.4430 0.436000 -0.039800 -0.065000 1.22e-02 8.19e-01 7.09e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 5.63e-11 8.07e-10 0.4430 0.403000 0.168000 -0.076800 5.11e-11 6.27e-03 2.11e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 3.49e-03 8.01e-03 0.4420 0.369000 0.018200 0.243000 1.68e-02 9.06e-01 1.16e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 2.47e-02 4.39e-02 0.4410 0.177000 -0.113000 -0.388000 2.89e-01 4.97e-01 1.99e-02
Nuclear Pore Complex (NPC) Disassembly 36 1.39e-04 5.04e-04 0.4410 -0.186000 -0.339000 0.212000 5.32e-02 4.34e-04 2.75e-02
Cellular response to hypoxia 71 2.46e-07 1.86e-06 0.4410 0.388000 0.209000 0.005170 1.49e-08 2.36e-03 9.40e-01
Mismatch Repair 15 8.95e-02 1.32e-01 0.4410 -0.242000 -0.363000 0.061600 1.05e-01 1.48e-02 6.79e-01
Interleukin-6 signaling 10 1.46e-01 1.99e-01 0.4400 0.401000 0.180000 -0.027000 2.81e-02 3.24e-01 8.82e-01
HDACs deacetylate histones 47 8.51e-07 5.94e-06 0.4390 0.358000 0.096200 -0.235000 2.16e-05 2.54e-01 5.34e-03
Plasma lipoprotein assembly, remodeling, and clearance 52 2.43e-05 1.09e-04 0.4380 0.250000 0.259000 -0.250000 1.81e-03 1.23e-03 1.85e-03
Synthesis of PC 23 2.37e-02 4.24e-02 0.4370 0.322000 0.224000 0.192000 7.45e-03 6.33e-02 1.11e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 9.88e-02 1.43e-01 0.4370 -0.235000 -0.360000 -0.076700 1.04e-01 1.26e-02 5.95e-01
Assembly of active LPL and LIPC lipase complexes 10 1.61e-01 2.15e-01 0.4360 0.204000 0.223000 -0.315000 2.64e-01 2.22e-01 8.48e-02
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.36e-01 1.87e-01 0.4360 -0.254000 -0.352000 0.042000 1.00e-01 2.24e-02 7.85e-01
VxPx cargo-targeting to cilium 19 8.64e-02 1.28e-01 0.4350 0.325000 0.274000 0.094800 1.43e-02 3.85e-02 4.75e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 2.93e-04 9.58e-04 0.4350 -0.248000 -0.277000 0.226000 5.35e-03 1.91e-03 1.12e-02
mTORC1-mediated signalling 24 3.92e-03 8.88e-03 0.4350 0.397000 0.162000 -0.074000 7.71e-04 1.69e-01 5.30e-01
MyD88 dependent cascade initiated on endosome 88 1.09e-10 1.46e-09 0.4350 0.396000 0.159000 -0.082300 1.34e-10 9.89e-03 1.82e-01
Fanconi Anemia Pathway 36 3.62e-03 8.25e-03 0.4350 -0.354000 -0.252000 -0.003880 2.37e-04 8.87e-03 9.68e-01
MET activates RAS signaling 10 1.51e-01 2.05e-01 0.4340 0.355000 0.164000 0.188000 5.19e-02 3.70e-01 3.04e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.61e-04 5.63e-04 0.4330 -0.228000 -0.283000 0.236000 9.62e-03 1.34e-03 7.37e-03
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 53 5.30e-06 2.94e-05 0.4330 0.387000 0.179000 0.074300 1.08e-06 2.39e-02 3.49e-01
Metabolism of porphyrins 22 2.62e-02 4.60e-02 0.4330 0.310000 0.233000 -0.191000 1.18e-02 5.85e-02 1.20e-01
RAF activation 32 8.30e-04 2.35e-03 0.4320 0.365000 0.169000 0.158000 3.52e-04 9.75e-02 1.21e-01
tRNA modification in the nucleus and cytosol 43 1.35e-03 3.56e-03 0.4320 -0.274000 -0.329000 0.055100 1.85e-03 1.87e-04 5.32e-01
Regulation of TP53 Activity through Acetylation 29 9.58e-03 1.93e-02 0.4320 -0.198000 -0.271000 -0.272000 6.55e-02 1.14e-02 1.13e-02
Regulation of ornithine decarboxylase (ODC) 49 1.22e-05 6.29e-05 0.4320 0.386000 0.174000 0.081900 2.90e-06 3.49e-02 3.21e-01
Clathrin-mediated endocytosis 127 4.10e-11 6.00e-10 0.4320 0.357000 0.230000 -0.075600 3.49e-12 7.66e-06 1.41e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 5.98e-02 9.35e-02 0.4290 0.388000 0.133000 0.126000 1.99e-02 4.24e-01 4.50e-01
Translation 295 6.44e-48 7.31e-46 0.4290 -0.055800 -0.394000 -0.160000 9.90e-02 2.01e-31 2.22e-06
Apoptosis induced DNA fragmentation 10 1.73e-01 2.26e-01 0.4290 0.377000 0.179000 0.101000 3.91e-02 3.28e-01 5.82e-01
SUMOylation of SUMOylation proteins 35 8.43e-04 2.38e-03 0.4290 -0.212000 -0.322000 0.188000 3.00e-02 9.71e-04 5.45e-02
Classical antibody-mediated complement activation 69 7.21e-10 9.01e-09 0.4290 -0.135000 -0.382000 0.141000 5.18e-02 4.21e-08 4.23e-02
MyD88 cascade initiated on plasma membrane 82 7.03e-11 9.68e-10 0.4280 0.395000 0.128000 -0.105000 6.13e-10 4.53e-02 1.01e-01
Toll Like Receptor 10 (TLR10) Cascade 82 7.03e-11 9.68e-10 0.4280 0.395000 0.128000 -0.105000 6.13e-10 4.53e-02 1.01e-01
Toll Like Receptor 5 (TLR5) Cascade 82 7.03e-11 9.68e-10 0.4280 0.395000 0.128000 -0.105000 6.13e-10 4.53e-02 1.01e-01
Transcription of E2F targets under negative control by DREAM complex 19 7.63e-05 2.94e-04 0.4280 0.011100 -0.416000 0.098900 9.33e-01 1.69e-03 4.55e-01
ER-Phagosome pathway 82 1.53e-07 1.19e-06 0.4280 0.366000 0.212000 0.064300 1.02e-08 9.10e-04 3.14e-01
p75NTR recruits signalling complexes 12 5.38e-02 8.60e-02 0.4270 0.246000 0.021100 -0.349000 1.40e-01 8.99e-01 3.65e-02
Plasma lipoprotein assembly 10 2.25e-01 2.82e-01 0.4270 0.234000 0.298000 -0.197000 1.99e-01 1.03e-01 2.82e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 5.14e-04 1.52e-03 0.4270 0.301000 0.074200 -0.293000 4.99e-03 4.89e-01 6.29e-03
Toll-like Receptor Cascades 143 1.26e-14 2.78e-13 0.4250 0.383000 0.184000 -0.009420 2.72e-15 1.40e-04 8.46e-01
tRNA Aminoacylation 42 7.07e-04 2.04e-03 0.4250 -0.243000 -0.321000 0.135000 6.51e-03 3.18e-04 1.29e-01
Cell-extracellular matrix interactions 14 1.01e-02 2.02e-02 0.4240 0.366000 0.021900 -0.214000 1.78e-02 8.87e-01 1.65e-01
TBC/RABGAPs 45 2.31e-04 7.77e-04 0.4240 0.289000 0.206000 -0.231000 7.88e-04 1.68e-02 7.32e-03
Signaling by NTRKs 115 1.38e-12 2.40e-11 0.4230 0.363000 0.157000 -0.149000 1.67e-11 3.57e-03 5.90e-03
Signaling by BRAF and RAF fusions 57 1.43e-06 9.07e-06 0.4220 0.390000 0.160000 -0.005320 3.46e-07 3.63e-02 9.45e-01
Innate Immune System 965 1.02e-85 6.95e-83 0.4210 0.367000 0.201000 -0.042300 8.53e-84 3.07e-26 2.60e-02
Signaling by NTRK1 (TRKA) 100 1.86e-11 2.82e-10 0.4200 0.367000 0.143000 -0.146000 2.21e-10 1.33e-02 1.18e-02
Negative regulation of FGFR3 signaling 20 4.95e-03 1.08e-02 0.4200 0.338000 0.069300 -0.240000 8.93e-03 5.92e-01 6.36e-02
G0 and Early G1 27 1.56e-06 9.84e-06 0.4190 0.019100 -0.386000 0.162000 8.63e-01 5.15e-04 1.44e-01
Removal of the Flap Intermediate from the C-strand 17 7.38e-02 1.12e-01 0.4190 -0.216000 -0.358000 0.026200 1.24e-01 1.06e-02 8.52e-01
Iron uptake and transport 52 1.54e-05 7.53e-05 0.4180 0.376000 0.171000 -0.068500 2.76e-06 3.31e-02 3.93e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 3.72e-05 1.56e-04 0.4180 0.340000 0.162000 0.182000 4.61e-05 5.25e-02 2.90e-02
Syndecan interactions 19 1.58e-05 7.65e-05 0.4180 0.352000 -0.155000 -0.165000 7.93e-03 2.43e-01 2.14e-01
Chemokine receptors bind chemokines 37 3.72e-04 1.18e-03 0.4180 -0.118000 -0.337000 -0.218000 2.14e-01 3.92e-04 2.19e-02
Cell recruitment (pro-inflammatory response) 22 2.09e-02 3.80e-02 0.4170 0.359000 0.186000 0.103000 3.55e-03 1.32e-01 4.01e-01
Purinergic signaling in leishmaniasis infection 22 2.09e-02 3.80e-02 0.4170 0.359000 0.186000 0.103000 3.55e-03 1.32e-01 4.01e-01
Activation of the AP-1 family of transcription factors 10 6.72e-02 1.03e-01 0.4170 0.390000 0.071700 -0.129000 3.26e-02 6.95e-01 4.80e-01
G beta:gamma signalling through CDC42 17 4.07e-02 6.79e-02 0.4170 0.359000 0.164000 0.136000 1.05e-02 2.41e-01 3.32e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 2.56e-05 1.14e-04 0.4170 0.377000 0.164000 0.067900 6.02e-06 4.98e-02 4.16e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 4.58e-02 7.47e-02 0.4160 0.304000 0.258000 0.120000 8.58e-03 2.54e-02 2.98e-01
Transcriptional Regulation by E2F6 34 1.86e-03 4.60e-03 0.4160 -0.210000 -0.312000 0.178000 3.44e-02 1.62e-03 7.26e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 1.83e-05 8.77e-05 0.4150 0.404000 0.095600 -0.011800 2.73e-05 3.21e-01 9.03e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 3.90e-06 2.22e-05 0.4140 0.367000 0.187000 0.040600 3.69e-07 9.56e-03 5.74e-01
MTOR signalling 39 7.03e-04 2.04e-03 0.4140 0.369000 0.187000 -0.014400 6.55e-05 4.31e-02 8.76e-01
Negative regulation of FGFR4 signaling 21 3.15e-03 7.33e-03 0.4140 0.313000 0.037700 -0.268000 1.29e-02 7.65e-01 3.38e-02
RORA activates gene expression 18 5.88e-02 9.23e-02 0.4140 0.312000 0.193000 -0.192000 2.21e-02 1.57e-01 1.59e-01
Recognition of DNA damage by PCNA-containing replication complex 30 1.44e-03 3.74e-03 0.4130 -0.165000 -0.372000 0.071200 1.18e-01 4.16e-04 5.00e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.75e-04 2.69e-03 0.4130 0.167000 0.017000 -0.378000 1.14e-01 8.72e-01 3.42e-04
Tat-mediated HIV elongation arrest and recovery 30 9.75e-04 2.69e-03 0.4130 0.167000 0.017000 -0.378000 1.14e-01 8.72e-01 3.42e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 7.12e-06 3.84e-05 0.4130 0.307000 0.258000 -0.098500 2.30e-06 7.52e-05 1.30e-01
DARPP-32 events 22 1.67e-03 4.21e-03 0.4120 0.401000 0.088600 -0.030600 1.11e-03 4.72e-01 8.04e-01
Platelet activation, signaling and aggregation 219 3.92e-22 1.13e-20 0.4120 0.360000 0.161000 -0.119000 3.93e-20 3.89e-05 2.36e-03
EPH-ephrin mediated repulsion of cells 39 7.91e-04 2.25e-03 0.4120 0.238000 0.193000 -0.275000 1.00e-02 3.70e-02 2.98e-03
Regulation of TP53 Activity through Association with Co-factors 11 1.73e-01 2.26e-01 0.4110 -0.074200 -0.186000 -0.359000 6.70e-01 2.84e-01 3.93e-02
Toll Like Receptor 9 (TLR9) Cascade 92 8.93e-11 1.20e-09 0.4110 0.382000 0.135000 -0.066100 2.36e-10 2.50e-02 2.73e-01
Scavenging of heme from plasma 71 5.59e-12 9.52e-11 0.4100 -0.069700 -0.381000 0.136000 3.10e-01 2.87e-08 4.79e-02
Cargo recognition for clathrin-mediated endocytosis 90 3.02e-07 2.24e-06 0.4100 0.333000 0.217000 -0.098800 4.64e-08 3.66e-04 1.05e-01
Signaling by MET 61 8.33e-06 4.38e-05 0.4100 0.366000 0.183000 -0.025100 7.71e-07 1.36e-02 7.35e-01
Synthesis of PIPs at the late endosome membrane 11 1.28e-01 1.79e-01 0.4100 0.205000 0.086300 0.344000 2.39e-01 6.20e-01 4.83e-02
Hedgehog ligand biogenesis 58 1.88e-05 8.91e-05 0.4090 0.356000 0.184000 0.082400 2.66e-06 1.53e-02 2.78e-01
Activation of G protein gated Potassium channels 19 5.48e-02 8.69e-02 0.4090 0.323000 0.189000 0.166000 1.48e-02 1.54e-01 2.09e-01
G protein gated Potassium channels 19 5.48e-02 8.69e-02 0.4090 0.323000 0.189000 0.166000 1.48e-02 1.54e-01 2.09e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 5.48e-02 8.69e-02 0.4090 0.323000 0.189000 0.166000 1.48e-02 1.54e-01 2.09e-01
Hh mutants abrogate ligand secretion 54 1.28e-05 6.49e-05 0.4090 0.367000 0.164000 0.076500 3.12e-06 3.73e-02 3.31e-01
Antiviral mechanism by IFN-stimulated genes 80 5.97e-08 5.05e-07 0.4090 -0.185000 -0.226000 0.286000 4.23e-03 4.85e-04 9.55e-06
Thrombin signalling through proteinase activated receptors (PARs) 27 9.12e-03 1.84e-02 0.4080 0.354000 0.180000 -0.097500 1.47e-03 1.06e-01 3.81e-01
Creation of C4 and C2 activators 71 1.88e-09 2.17e-08 0.4080 -0.123000 -0.361000 0.145000 7.29e-02 1.38e-07 3.49e-02
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 4.55e-02 7.42e-02 0.4080 -0.274000 0.034700 0.300000 1.15e-01 8.42e-01 8.50e-02
Folding of actin by CCT/TriC 10 2.71e-03 6.43e-03 0.4070 0.135000 -0.380000 0.059500 4.61e-01 3.76e-02 7.44e-01
Defective CFTR causes cystic fibrosis 59 6.19e-06 3.38e-05 0.4060 0.366000 0.167000 0.059000 1.17e-06 2.66e-02 4.33e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.25e-02 2.43e-02 0.4060 0.366000 0.058900 -0.165000 1.12e-02 6.83e-01 2.52e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.12e-02 6.86e-02 0.4060 -0.223000 -0.329000 -0.082700 5.40e-02 4.37e-03 4.74e-01
Beta-oxidation of very long chain fatty acids 10 3.73e-01 4.31e-01 0.4050 0.278000 0.287000 -0.069100 1.28e-01 1.17e-01 7.05e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.46e-03 3.79e-03 0.4050 0.287000 0.042900 -0.283000 1.14e-02 7.05e-01 1.25e-02
RAB geranylgeranylation 60 6.20e-06 3.38e-05 0.4040 0.366000 0.168000 0.033900 9.21e-07 2.43e-02 6.49e-01
Plasma lipoprotein remodeling 18 7.01e-02 1.07e-01 0.4040 0.222000 0.276000 -0.195000 1.03e-01 4.26e-02 1.53e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 4.04e-05 1.67e-04 0.4030 0.242000 -0.063900 -0.315000 1.76e-02 5.32e-01 2.05e-03
HS-GAG degradation 16 4.14e-02 6.89e-02 0.4020 0.141000 0.001570 -0.377000 3.29e-01 9.91e-01 9.06e-03
Nuclear Events (kinase and transcription factor activation) 53 4.79e-06 2.68e-05 0.4020 0.319000 0.104000 -0.222000 5.83e-05 1.92e-01 5.24e-03
ADP signalling through P2Y purinoceptor 12 18 1.73e-02 3.22e-02 0.4010 0.376000 0.119000 0.074300 5.73e-03 3.81e-01 5.85e-01
Interleukin-1 family signaling 124 3.38e-11 5.07e-10 0.4010 0.360000 0.177000 -0.011200 4.29e-12 6.68e-04 8.30e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 2.05e-02 3.73e-02 0.4010 0.364000 0.082100 -0.146000 1.16e-02 5.70e-01 3.12e-01
FCGR activation 76 9.80e-09 1.03e-07 0.4000 -0.144000 -0.357000 0.111000 2.98e-02 7.59e-08 9.31e-02
Beta-catenin phosphorylation cascade 17 4.61e-02 7.50e-02 0.4000 0.365000 0.149000 -0.067800 9.25e-03 2.86e-01 6.29e-01
Interferon alpha/beta signaling 57 3.67e-08 3.26e-07 0.3990 -0.283000 0.001440 0.282000 2.20e-04 9.85e-01 2.31e-04
Regulation of Apoptosis 51 1.92e-05 9.03e-05 0.3990 0.357000 0.145000 0.103000 1.01e-05 7.34e-02 2.01e-01
Signaling by EGFR 46 4.00e-06 2.27e-05 0.3990 0.334000 0.062500 -0.208000 8.69e-05 4.63e-01 1.46e-02
NGF-stimulated transcription 31 4.97e-04 1.47e-03 0.3980 0.247000 0.018800 -0.312000 1.73e-02 8.56e-01 2.65e-03
Cohesin Loading onto Chromatin 10 4.35e-03 9.73e-03 0.3980 0.193000 -0.269000 0.221000 2.92e-01 1.41e-01 2.26e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 4.06e-02 6.78e-02 0.3970 0.287000 0.078700 -0.262000 4.69e-02 5.86e-01 6.96e-02
IKK complex recruitment mediated by RIP1 23 1.24e-02 2.41e-02 0.3960 0.357000 0.145000 0.092000 3.03e-03 2.28e-01 4.45e-01
Signaling by PDGFRA extracellular domain mutants 12 6.53e-02 1.00e-01 0.3960 0.287000 0.062000 0.265000 8.47e-02 7.10e-01 1.13e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 6.53e-02 1.00e-01 0.3960 0.287000 0.062000 0.265000 8.47e-02 7.10e-01 1.13e-01
Vif-mediated degradation of APOBEC3G 52 3.76e-05 1.57e-04 0.3950 0.358000 0.157000 0.061500 8.04e-06 5.06e-02 4.43e-01
tRNA processing 134 2.83e-08 2.55e-07 0.3940 -0.256000 -0.300000 -0.007600 3.12e-07 2.05e-09 8.79e-01
IRAK2 mediated activation of TAK1 complex 10 2.04e-02 3.72e-02 0.3940 0.254000 -0.167000 -0.250000 1.64e-01 3.62e-01 1.71e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 4.44e-06 2.50e-05 0.3930 0.391000 -0.005090 0.047000 2.13e-04 9.62e-01 6.56e-01
Degradation of DVL 54 2.92e-05 1.26e-04 0.3930 0.360000 0.157000 0.021400 4.80e-06 4.58e-02 7.85e-01
Senescence-Associated Secretory Phenotype (SASP) 66 2.65e-08 2.41e-07 0.3920 0.299000 0.044200 -0.250000 2.67e-05 5.35e-01 4.39e-04
PKA activation 15 4.38e-02 7.20e-02 0.3920 0.265000 0.043500 -0.286000 7.57e-02 7.70e-01 5.52e-02
Carnitine metabolism 10 4.11e-01 4.66e-01 0.3900 0.281000 0.262000 -0.066600 1.24e-01 1.51e-01 7.15e-01
Thromboxane signalling through TP receptor 20 1.22e-02 2.39e-02 0.3900 0.374000 0.110000 -0.017300 3.82e-03 3.93e-01 8.94e-01
Intraflagellar transport 39 1.00e-02 2.00e-02 0.3900 -0.254000 -0.292000 0.050000 6.11e-03 1.63e-03 5.89e-01
Negative regulation of FGFR1 signaling 24 1.93e-02 3.53e-02 0.3900 0.299000 0.145000 -0.204000 1.13e-02 2.17e-01 8.42e-02
Regulation of localization of FOXO transcription factors 11 1.16e-01 1.64e-01 0.3900 0.241000 0.024800 -0.305000 1.67e-01 8.87e-01 7.94e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 9.21e-06 4.79e-05 0.3890 0.366000 0.129000 0.007850 3.95e-06 1.03e-01 9.21e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 1.24e-02 2.41e-02 0.3890 0.185000 0.101000 -0.327000 1.10e-01 3.84e-01 4.70e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 1.88e-05 8.91e-05 0.3880 0.350000 0.134000 0.101000 1.24e-05 9.41e-02 2.08e-01
Adenylate cyclase inhibitory pathway 11 2.63e-01 3.22e-01 0.3880 0.216000 0.251000 -0.202000 2.14e-01 1.50e-01 2.45e-01
Signaling by NOTCH4 78 5.74e-06 3.15e-05 0.3880 0.336000 0.193000 -0.000360 2.84e-07 3.15e-03 9.96e-01
Regulation of PTEN stability and activity 66 1.56e-05 7.58e-05 0.3870 0.341000 0.175000 0.052700 1.63e-06 1.37e-02 4.59e-01
PINK1-PRKN Mediated Mitophagy 21 2.09e-05 9.64e-05 0.3870 0.187000 -0.294000 -0.170000 1.39e-01 1.97e-02 1.79e-01
MAP kinase activation 63 1.31e-07 1.03e-06 0.3870 0.366000 0.096800 -0.077100 4.93e-07 1.84e-01 2.90e-01
Negative regulation of NOTCH4 signaling 54 3.22e-05 1.37e-04 0.3870 0.353000 0.150000 0.051400 7.32e-06 5.73e-02 5.14e-01
Dectin-2 family 19 5.57e-02 8.81e-02 0.3860 0.161000 0.347000 0.050200 2.25e-01 8.75e-03 7.05e-01
RAB GEFs exchange GTP for GDP on RABs 87 8.41e-06 4.40e-05 0.3860 0.316000 0.220000 -0.023400 3.51e-07 3.90e-04 7.06e-01
Calnexin/calreticulin cycle 26 4.36e-03 9.73e-03 0.3860 0.365000 0.118000 -0.042500 1.29e-03 2.98e-01 7.07e-01
Metabolism of steroid hormones 19 1.36e-01 1.87e-01 0.3850 0.311000 0.225000 0.027600 1.87e-02 8.92e-02 8.35e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 6.35e-02 9.85e-02 0.3850 -0.259000 -0.271000 -0.087400 1.77e-02 1.32e-02 4.23e-01
Degradation of the extracellular matrix 77 1.51e-05 7.47e-05 0.3850 0.236000 0.258000 -0.159000 3.38e-04 8.85e-05 1.56e-02
Apoptotic factor-mediated response 18 1.01e-01 1.46e-01 0.3840 0.312000 0.184000 0.129000 2.19e-02 1.77e-01 3.43e-01
Presynaptic function of Kainate receptors 18 9.76e-02 1.42e-01 0.3840 0.320000 0.184000 -0.104000 1.87e-02 1.77e-01 4.45e-01
G beta:gamma signalling through PLC beta 17 6.82e-02 1.04e-01 0.3830 0.340000 0.146000 -0.100000 1.53e-02 2.97e-01 4.75e-01
Glycosphingolipid metabolism 36 9.37e-03 1.88e-02 0.3830 0.253000 0.235000 -0.166000 8.55e-03 1.48e-02 8.50e-02
Biosynthesis of DHA-derived SPMs 14 5.47e-02 8.69e-02 0.3830 0.198000 -0.023300 -0.327000 1.99e-01 8.80e-01 3.43e-02
Rap1 signalling 13 1.28e-01 1.79e-01 0.3820 0.302000 0.128000 0.197000 5.98e-02 4.25e-01 2.19e-01
HDMs demethylate histones 22 6.65e-02 1.02e-01 0.3820 0.244000 0.230000 -0.182000 4.78e-02 6.18e-02 1.39e-01
Degradation of GLI1 by the proteasome 57 2.04e-05 9.47e-05 0.3810 0.344000 0.144000 0.076500 6.83e-06 6.05e-02 3.18e-01
ISG15 antiviral mechanism 72 1.10e-06 7.30e-06 0.3800 -0.152000 -0.243000 0.249000 2.58e-02 3.59e-04 2.55e-04
Heparan sulfate/heparin (HS-GAG) metabolism 37 1.11e-03 3.02e-03 0.3800 0.116000 0.049400 -0.358000 2.23e-01 6.03e-01 1.63e-04
Nucleotide salvage 21 6.50e-02 1.00e-01 0.3800 0.316000 0.181000 -0.106000 1.22e-02 1.50e-01 3.99e-01
Regulation of signaling by CBL 18 1.77e-01 2.30e-01 0.3790 0.261000 0.266000 -0.068200 5.48e-02 5.07e-02 6.16e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 1.81e-01 2.34e-01 0.3790 -0.020900 -0.199000 -0.321000 9.05e-01 2.53e-01 6.49e-02
Degradation of cysteine and homocysteine 12 1.74e-01 2.27e-01 0.3790 0.153000 0.108000 -0.329000 3.58e-01 5.18e-01 4.84e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs 82 1.83e-08 1.76e-07 0.3780 0.356000 0.119000 -0.044700 2.56e-08 6.24e-02 4.84e-01
Golgi-to-ER retrograde transport 111 1.75e-08 1.70e-07 0.3770 0.329000 0.175000 0.058700 1.99e-09 1.49e-03 2.85e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 2.19e-04 7.43e-04 0.3770 0.119000 -0.170000 0.315000 3.15e-01 1.50e-01 7.49e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.80e-01 2.33e-01 0.3770 0.295000 0.222000 -0.075600 3.51e-02 1.13e-01 5.90e-01
Degradation of GLI2 by the proteasome 56 9.34e-06 4.84e-05 0.3760 0.349000 0.122000 0.062400 6.06e-06 1.13e-01 4.19e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 6.50e-05 2.55e-04 0.3750 0.345000 0.132000 0.065500 2.40e-05 1.06e-01 4.23e-01
p53-Independent DNA Damage Response 50 6.50e-05 2.55e-04 0.3750 0.345000 0.132000 0.065500 2.40e-05 1.06e-01 4.23e-01
p53-Independent G1/S DNA damage checkpoint 50 6.50e-05 2.55e-04 0.3750 0.345000 0.132000 0.065500 2.40e-05 1.06e-01 4.23e-01
Interleukin-2 signaling 11 1.97e-01 2.51e-01 0.3750 0.038700 -0.002260 -0.373000 8.24e-01 9.90e-01 3.23e-02
Glucagon signaling in metabolic regulation 27 8.06e-03 1.65e-02 0.3750 0.333000 0.122000 -0.120000 2.73e-03 2.73e-01 2.79e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 6.88e-03 1.43e-02 0.3740 -0.027300 -0.358000 0.104000 8.50e-01 1.31e-02 4.70e-01
Termination of translesion DNA synthesis 32 1.71e-02 3.21e-02 0.3740 -0.206000 -0.300000 0.085200 4.40e-02 3.26e-03 4.04e-01
Defects in vitamin and cofactor metabolism 21 1.39e-01 1.90e-01 0.3740 -0.255000 -0.269000 0.048600 4.27e-02 3.31e-02 7.00e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 6.23e-03 1.30e-02 0.3730 0.336000 0.111000 -0.120000 2.52e-03 3.19e-01 2.81e-01
Endogenous sterols 16 1.74e-01 2.27e-01 0.3730 0.319000 0.193000 -0.006640 2.69e-02 1.82e-01 9.63e-01
RNA Polymerase I Transcription Initiation 44 4.91e-03 1.07e-02 0.3730 -0.200000 -0.312000 -0.044300 2.17e-02 3.44e-04 6.11e-01
Long-term potentiation 14 1.56e-01 2.09e-01 0.3730 -0.130000 -0.315000 -0.152000 4.00e-01 4.14e-02 3.23e-01
SUMOylation of DNA replication proteins 46 2.09e-04 7.10e-04 0.3730 -0.145000 -0.274000 0.207000 8.95e-02 1.28e-03 1.51e-02
SUMOylation of ubiquitinylation proteins 39 2.45e-03 5.88e-03 0.3720 -0.178000 -0.235000 0.228000 5.46e-02 1.12e-02 1.37e-02
Signaling by EGFR in Cancer 23 7.12e-04 2.06e-03 0.3720 0.344000 -0.008890 -0.142000 4.31e-03 9.41e-01 2.38e-01
Base-Excision Repair, AP Site Formation 31 4.26e-04 1.31e-03 0.3710 0.252000 -0.018400 -0.272000 1.51e-02 8.59e-01 8.82e-03
Signaling by NOTCH 182 8.24e-15 1.84e-13 0.3700 0.316000 0.143000 -0.129000 1.86e-13 8.58e-04 2.73e-03
Mitotic Telophase/Cytokinesis 13 1.56e-03 3.99e-03 0.3700 0.274000 -0.178000 0.175000 8.75e-02 2.68e-01 2.75e-01
Trafficking and processing of endosomal TLR 13 2.63e-01 3.22e-01 0.3700 0.301000 0.186000 0.108000 6.00e-02 2.45e-01 5.02e-01
PCP/CE pathway 86 2.15e-06 1.33e-05 0.3700 0.305000 0.167000 -0.126000 1.03e-06 7.28e-03 4.33e-02
Metabolism of amine-derived hormones 10 3.90e-01 4.46e-01 0.3690 -0.193000 -0.314000 -0.020600 2.91e-01 8.54e-02 9.10e-01
O-glycosylation of TSR domain-containing proteins 25 2.25e-02 4.04e-02 0.3690 -0.320000 -0.145000 -0.112000 5.54e-03 2.09e-01 3.34e-01
TNFR1-induced proapoptotic signaling 12 2.94e-01 3.54e-01 0.3690 -0.316000 -0.187000 0.033800 5.80e-02 2.62e-01 8.39e-01
Signaling by ROBO receptors 199 1.39e-21 3.95e-20 0.3690 -0.010200 -0.263000 -0.259000 8.04e-01 1.66e-10 3.11e-10
Nuclear Receptor transcription pathway 36 2.37e-03 5.74e-03 0.3680 0.006860 -0.080400 -0.359000 9.43e-01 4.04e-01 1.90e-04
Oncogenic MAPK signaling 73 5.56e-06 3.07e-05 0.3680 0.334000 0.153000 0.030200 8.24e-07 2.36e-02 6.55e-01
G beta:gamma signalling through PI3Kgamma 22 9.20e-02 1.35e-01 0.3680 0.286000 0.202000 -0.114000 2.01e-02 1.01e-01 3.57e-01
Amino acids regulate mTORC1 50 1.49e-03 3.85e-03 0.3670 0.315000 0.186000 -0.041200 1.19e-04 2.32e-02 6.14e-01
MASTL Facilitates Mitotic Progression 10 3.67e-02 6.23e-02 0.3670 0.289000 -0.060000 0.218000 1.14e-01 7.43e-01 2.32e-01
RMTs methylate histone arginines 37 1.86e-03 4.61e-03 0.3670 0.006530 -0.116000 -0.348000 9.45e-01 2.22e-01 2.52e-04
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 2.24e-02 4.04e-02 0.3660 0.192000 0.014100 -0.312000 1.28e-01 9.11e-01 1.34e-02
RNA Polymerase III Chain Elongation 18 1.83e-01 2.36e-01 0.3660 -0.189000 -0.284000 -0.132000 1.64e-01 3.70e-02 3.33e-01
MyD88-independent TLR4 cascade 96 1.89e-08 1.80e-07 0.3660 0.339000 0.134000 -0.027900 8.95e-09 2.36e-02 6.37e-01
TRIF(TICAM1)-mediated TLR4 signaling 96 1.89e-08 1.80e-07 0.3660 0.339000 0.134000 -0.027900 8.95e-09 2.36e-02 6.37e-01
Collagen formation 64 2.76e-05 1.20e-04 0.3660 0.162000 0.150000 -0.292000 2.53e-02 3.77e-02 5.38e-05
Transport to the Golgi and subsequent modification 155 6.36e-10 8.02e-09 0.3660 0.312000 0.190000 0.014500 1.87e-11 4.55e-05 7.55e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 9.46e-02 1.38e-01 0.3650 -0.248000 -0.249000 -0.099600 2.56e-02 2.52e-02 3.70e-01
Interleukin-17 signaling 68 8.84e-07 6.11e-06 0.3650 0.337000 0.104000 -0.095700 1.58e-06 1.38e-01 1.72e-01
SUMOylation of RNA binding proteins 47 1.27e-03 3.39e-03 0.3650 -0.181000 -0.304000 0.090400 3.17e-02 3.16e-04 2.83e-01
Myogenesis 21 1.73e-01 2.26e-01 0.3650 0.270000 0.244000 0.027100 3.23e-02 5.28e-02 8.30e-01
L1CAM interactions 84 3.16e-05 1.35e-04 0.3650 0.303000 0.201000 -0.035200 1.63e-06 1.48e-03 5.77e-01
HDR through Homologous Recombination (HRR) 66 1.34e-04 4.87e-04 0.3640 -0.232000 -0.198000 0.200000 1.10e-03 5.51e-03 5.04e-03
Triglyceride catabolism 16 1.62e-01 2.15e-01 0.3640 0.317000 0.173000 -0.049300 2.82e-02 2.31e-01 7.33e-01
Translesion Synthesis by POLH 18 6.10e-02 9.50e-02 0.3640 -0.126000 -0.338000 -0.051000 3.55e-01 1.31e-02 7.08e-01
Cleavage of the damaged pyrimidine 29 4.46e-04 1.35e-03 0.3640 0.274000 -0.025700 -0.238000 1.06e-02 8.11e-01 2.66e-02
Depyrimidination 29 4.46e-04 1.35e-03 0.3640 0.274000 -0.025700 -0.238000 1.06e-02 8.11e-01 2.66e-02
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 4.46e-04 1.35e-03 0.3640 0.274000 -0.025700 -0.238000 1.06e-02 8.11e-01 2.66e-02
Downregulation of ERBB2:ERBB3 signaling 12 1.01e-01 1.45e-01 0.3640 0.153000 -0.077100 -0.321000 3.57e-01 6.44e-01 5.44e-02
Defective B3GAT3 causes JDSSDHD 11 2.22e-01 2.79e-01 0.3630 -0.008330 -0.154000 -0.329000 9.62e-01 3.77e-01 5.89e-02
Defects in cobalamin (B12) metabolism 13 1.93e-01 2.46e-01 0.3630 -0.165000 -0.261000 0.192000 3.04e-01 1.03e-01 2.32e-01
Vpu mediated degradation of CD4 50 4.56e-05 1.85e-04 0.3630 0.342000 0.110000 0.053400 2.94e-05 1.77e-01 5.13e-01
NIK–>noncanonical NF-kB signaling 57 1.75e-05 8.43e-05 0.3620 0.339000 0.118000 0.051300 9.72e-06 1.24e-01 5.03e-01
Initial triggering of complement 78 7.45e-08 6.15e-07 0.3620 -0.116000 -0.305000 0.156000 7.63e-02 3.09e-06 1.70e-02
G beta:gamma signalling through BTK 15 1.45e-01 1.97e-01 0.3610 0.322000 0.147000 0.069100 3.09e-02 3.23e-01 6.43e-01
Deadenylation of mRNA 22 1.49e-04 5.31e-04 0.3610 0.153000 -0.203000 0.256000 2.15e-01 9.91e-02 3.79e-02
The role of GTSE1 in G2/M progression after G2 checkpoint 58 2.75e-06 1.65e-05 0.3600 0.331000 0.088500 0.112000 1.31e-05 2.44e-01 1.40e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 9.02e-04 2.52e-03 0.3600 0.349000 0.072400 -0.051800 7.76e-04 4.85e-01 6.18e-01
Cytosolic tRNA aminoacylation 24 1.90e-02 3.49e-02 0.3600 -0.130000 -0.270000 0.200000 2.71e-01 2.22e-02 9.00e-02
GABA receptor activation 35 4.06e-02 6.78e-02 0.3600 0.270000 0.226000 0.074000 5.78e-03 2.05e-02 4.48e-01
Caspase activation via Death Receptors in the presence of ligand 16 2.09e-01 2.65e-01 0.3590 0.259000 0.179000 0.172000 7.27e-02 2.15e-01 2.33e-01
Membrane Trafficking 557 2.78e-34 1.26e-32 0.3590 0.309000 0.183000 -0.016600 1.11e-35 1.58e-13 5.04e-01
Acetylcholine Neurotransmitter Release Cycle 11 3.16e-01 3.76e-01 0.3590 -0.105000 -0.226000 -0.258000 5.48e-01 1.94e-01 1.38e-01
HIV elongation arrest and recovery 32 4.53e-03 1.01e-02 0.3580 0.158000 0.023700 -0.320000 1.22e-01 8.17e-01 1.72e-03
Pausing and recovery of HIV elongation 32 4.53e-03 1.01e-02 0.3580 0.158000 0.023700 -0.320000 1.22e-01 8.17e-01 1.72e-03
Signaling by NOTCH1 66 5.88e-05 2.35e-04 0.3570 0.284000 0.143000 -0.162000 6.56e-05 4.40e-02 2.31e-02
Signaling by cytosolic FGFR1 fusion mutants 17 1.61e-01 2.14e-01 0.3570 0.288000 0.166000 0.130000 4.01e-02 2.35e-01 3.53e-01
Glutamate and glutamine metabolism 12 1.87e-01 2.40e-01 0.3560 -0.097700 -0.315000 -0.134000 5.58e-01 5.90e-02 4.22e-01
Signaling by NOTCH3 42 1.91e-03 4.71e-03 0.3560 0.247000 0.117000 -0.228000 5.69e-03 1.91e-01 1.05e-02
Activation of GABAB receptors 30 6.24e-02 9.68e-02 0.3560 0.284000 0.212000 0.031100 7.09e-03 4.48e-02 7.68e-01
GABA B receptor activation 30 6.24e-02 9.68e-02 0.3560 0.284000 0.212000 0.031100 7.09e-03 4.48e-02 7.68e-01
Metabolism of polyamines 57 1.46e-05 7.26e-05 0.3560 0.330000 0.105000 0.082100 1.67e-05 1.70e-01 2.84e-01
Ubiquitin-dependent degradation of Cyclin D 50 1.87e-04 6.46e-04 0.3550 0.331000 0.125000 0.026400 5.00e-05 1.26e-01 7.47e-01
Regulation of IFNA signaling 12 3.51e-01 4.11e-01 0.3550 0.185000 0.300000 0.038000 2.66e-01 7.17e-02 8.20e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 1.52e-01 2.05e-01 0.3540 0.027700 -0.018300 -0.353000 8.58e-01 9.06e-01 2.23e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 1.52e-01 2.05e-01 0.3540 0.027700 -0.018300 -0.353000 8.58e-01 9.06e-01 2.23e-02
Role of LAT2/NTAL/LAB on calcium mobilization 74 1.03e-09 1.22e-08 0.3540 -0.052600 -0.336000 0.098100 4.34e-01 5.61e-07 1.45e-01
Condensation of Prophase Chromosomes 29 6.13e-04 1.78e-03 0.3540 0.304000 0.001250 -0.181000 4.63e-03 9.91e-01 9.09e-02
Downregulation of ERBB2 signaling 24 1.85e-03 4.60e-03 0.3540 0.216000 -0.089300 -0.265000 6.66e-02 4.49e-01 2.44e-02
Semaphorin interactions 57 2.26e-03 5.49e-03 0.3540 0.253000 0.220000 -0.113000 9.61e-04 4.06e-03 1.41e-01
Interleukin-10 signaling 34 9.05e-03 1.83e-02 0.3530 0.307000 0.142000 -0.100000 1.94e-03 1.53e-01 3.12e-01
Collagen chain trimerization 27 1.96e-02 3.59e-02 0.3520 0.003530 -0.083400 -0.342000 9.75e-01 4.53e-01 2.08e-03
Retinoid metabolism and transport 24 6.60e-02 1.01e-01 0.3520 0.209000 0.190000 -0.210000 7.57e-02 1.07e-01 7.54e-02
GLI3 is processed to GLI3R by the proteasome 57 1.76e-05 8.43e-05 0.3520 0.333000 0.104000 0.043900 1.37e-05 1.73e-01 5.66e-01
Dectin-1 mediated noncanonical NF-kB signaling 58 2.14e-05 9.83e-05 0.3520 0.332000 0.110000 0.034300 1.21e-05 1.46e-01 6.52e-01
Aquaporin-mediated transport 37 1.30e-03 3.45e-03 0.3510 0.313000 0.091100 -0.131000 9.99e-04 3.38e-01 1.67e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 6.40e-02 9.89e-02 0.3510 0.124000 0.083100 -0.318000 3.38e-01 5.20e-01 1.39e-02
G-protein activation 23 2.07e-02 3.77e-02 0.3510 0.325000 0.106000 0.077800 6.91e-03 3.78e-01 5.18e-01
Repression of WNT target genes 14 2.15e-01 2.72e-01 0.3510 -0.149000 -0.119000 -0.295000 3.35e-01 4.40e-01 5.64e-02
Diseases associated with glycosylation precursor biosynthesis 18 2.09e-01 2.65e-01 0.3510 0.290000 0.196000 0.020600 3.34e-02 1.49e-01 8.79e-01
ER Quality Control Compartment (ERQC) 21 3.31e-02 5.68e-02 0.3500 0.333000 0.110000 -0.002120 8.31e-03 3.84e-01 9.87e-01
N-Glycan antennae elongation 13 2.61e-01 3.21e-01 0.3500 -0.096000 -0.162000 -0.295000 5.49e-01 3.12e-01 6.54e-02
Interleukin-27 signaling 11 3.81e-01 4.37e-01 0.3500 0.276000 0.171000 0.131000 1.13e-01 3.26e-01 4.51e-01
MET promotes cell motility 26 7.95e-02 1.19e-01 0.3500 0.294000 0.189000 0.017400 9.47e-03 9.56e-02 8.78e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 1.52e-05 7.49e-05 0.3490 0.256000 0.023500 -0.237000 1.26e-03 7.67e-01 2.89e-03
Chondroitin sulfate/dermatan sulfate metabolism 38 2.64e-03 6.29e-03 0.3480 0.079200 -0.010500 -0.339000 3.98e-01 9.11e-01 2.98e-04
ABC transporter disorders 70 2.85e-05 1.24e-04 0.3480 0.318000 0.141000 -0.000776 4.11e-06 4.07e-02 9.91e-01
Defective B4GALT7 causes EDS, progeroid type 11 2.98e-01 3.58e-01 0.3480 -0.044600 -0.139000 -0.316000 7.98e-01 4.25e-01 7.00e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 3.37e-02 5.77e-02 0.3470 0.155000 0.033600 -0.309000 1.99e-01 7.80e-01 1.03e-02
Interleukin-15 signaling 14 3.45e-01 4.06e-01 0.3470 0.238000 0.236000 -0.088700 1.23e-01 1.27e-01 5.66e-01
VEGFA-VEGFR2 Pathway 90 7.93e-06 4.22e-05 0.3470 0.295000 0.161000 -0.083600 1.29e-06 8.16e-03 1.70e-01
PPARA activates gene expression 104 3.82e-05 1.59e-04 0.3460 0.270000 0.217000 0.012800 2.03e-06 1.32e-04 8.22e-01
Cristae formation 31 1.74e-03 4.38e-03 0.3460 0.263000 0.017100 -0.224000 1.11e-02 8.69e-01 3.10e-02
FCERI mediated Ca+2 mobilization 89 9.54e-10 1.14e-08 0.3450 -0.077600 -0.328000 0.073800 2.05e-01 8.56e-08 2.29e-01
EPHA-mediated growth cone collapse 13 3.50e-01 4.11e-01 0.3450 0.287000 0.185000 0.048300 7.35e-02 2.47e-01 7.63e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.24e-02 2.41e-02 0.3450 0.229000 0.058600 -0.251000 3.63e-02 5.92e-01 2.13e-02
Rab regulation of trafficking 120 1.48e-06 9.35e-06 0.3430 0.269000 0.192000 -0.092200 3.41e-07 2.84e-04 8.11e-02
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 5.78e-03 1.22e-02 0.3420 0.058200 -0.175000 -0.288000 6.01e-01 1.15e-01 9.53e-03
Integration of energy metabolism 86 2.64e-05 1.16e-04 0.3420 0.287000 0.164000 -0.086900 4.19e-06 8.60e-03 1.64e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 1.59e-03 4.06e-03 0.3410 0.314000 0.076000 -0.110000 1.30e-03 4.37e-01 2.60e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 2.89e-02 5.03e-02 0.3410 0.239000 0.230000 -0.079000 8.83e-03 1.19e-02 3.87e-01
Signaling by Insulin receptor 59 4.61e-04 1.39e-03 0.3410 0.295000 0.146000 -0.087000 8.65e-05 5.32e-02 2.48e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 4.47e-04 1.35e-03 0.3390 0.316000 0.117000 0.040500 1.29e-04 1.56e-01 6.24e-01
Assembly of collagen fibrils and other multimeric structures 42 3.21e-03 7.43e-03 0.3390 0.137000 0.160000 -0.267000 1.25e-01 7.34e-02 2.80e-03
SIRT1 negatively regulates rRNA expression 24 2.42e-03 5.83e-03 0.3380 0.279000 -0.033700 -0.188000 1.80e-02 7.75e-01 1.10e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.71e-02 6.28e-02 0.3380 0.279000 -0.102000 -0.161000 1.09e-01 5.59e-01 3.55e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 1.36e-02 2.59e-02 0.3370 -0.175000 -0.078600 0.277000 8.63e-02 4.41e-01 6.59e-03
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 2.77e-02 4.83e-02 0.3370 -0.076800 -0.316000 0.088200 5.62e-01 1.70e-02 5.06e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 24 4.38e-02 7.20e-02 0.3360 -0.299000 -0.124000 -0.092000 1.12e-02 2.95e-01 4.35e-01
NRIF signals cell death from the nucleus 15 1.06e-01 1.51e-01 0.3360 0.217000 0.021600 -0.256000 1.46e-01 8.85e-01 8.61e-02
Formation of the beta-catenin:TCF transactivating complex 46 1.56e-04 5.46e-04 0.3360 0.212000 -0.005410 -0.261000 1.30e-02 9.49e-01 2.23e-03
XBP1(S) activates chaperone genes 47 4.67e-03 1.03e-02 0.3350 0.278000 0.154000 -0.107000 9.69e-04 6.80e-02 2.05e-01
Collagen biosynthesis and modifying enzymes 46 1.55e-03 3.98e-03 0.3350 0.107000 0.082400 -0.307000 2.08e-01 3.34e-01 3.18e-04
Acyl chain remodelling of PI 10 3.94e-01 4.50e-01 0.3350 0.301000 0.144000 -0.031400 9.92e-02 4.30e-01 8.63e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.26e-01 2.83e-01 0.3350 0.041700 0.235000 0.236000 8.03e-01 1.59e-01 1.58e-01
Uptake and actions of bacterial toxins 27 1.72e-02 3.22e-02 0.3330 0.306000 0.095900 -0.091600 5.95e-03 3.88e-01 4.10e-01
Complex I biogenesis 55 4.09e-04 1.27e-03 0.3330 0.251000 0.098500 -0.196000 1.30e-03 2.06e-01 1.19e-02
ERBB2 Regulates Cell Motility 10 9.44e-02 1.38e-01 0.3330 0.315000 -0.020100 -0.106000 8.47e-02 9.12e-01 5.61e-01
Lewis blood group biosynthesis 13 2.29e-01 2.87e-01 0.3320 0.038700 -0.013800 -0.329000 8.09e-01 9.31e-01 3.99e-02
SHC1 events in ERBB4 signaling 10 8.43e-02 1.25e-01 0.3320 0.331000 -0.009700 0.002790 6.96e-02 9.58e-01 9.88e-01
Laminin interactions 21 4.39e-02 7.20e-02 0.3310 0.241000 0.047400 -0.223000 5.62e-02 7.07e-01 7.75e-02
PLC beta mediated events 43 4.02e-03 9.07e-03 0.3310 0.270000 0.119000 -0.150000 2.19e-03 1.77e-01 8.92e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 3.96e-04 1.24e-03 0.3310 0.297000 0.066200 -0.131000 6.57e-04 4.48e-01 1.34e-01
Synthesis of IP3 and IP4 in the cytosol 22 6.02e-02 9.39e-02 0.3310 0.091300 0.119000 -0.295000 4.59e-01 3.36e-01 1.66e-02
Costimulation by the CD28 family 74 2.77e-03 6.56e-03 0.3300 -0.224000 -0.236000 -0.055600 8.81e-04 4.42e-04 4.08e-01
Metabolism of fat-soluble vitamins 28 5.20e-02 8.34e-02 0.3300 0.207000 0.145000 -0.212000 5.82e-02 1.83e-01 5.21e-02
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 1.99e-03 4.89e-03 0.3300 0.288000 0.139000 0.080500 3.72e-04 8.52e-02 3.20e-01
Post-chaperonin tubulin folding pathway 19 1.54e-01 2.07e-01 0.3300 0.280000 0.145000 -0.096200 3.46e-02 2.72e-01 4.68e-01
Nuclear signaling by ERBB4 24 2.24e-02 4.04e-02 0.3290 0.243000 0.037400 -0.219000 3.92e-02 7.51e-01 6.31e-02
Regulation of RUNX3 expression and activity 55 3.44e-04 1.10e-03 0.3290 0.307000 0.117000 0.023700 8.41e-05 1.33e-01 7.61e-01
Autophagy 124 7.65e-10 9.33e-09 0.3290 0.310000 0.100000 -0.043500 2.38e-09 5.46e-02 4.03e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.24e-04 4.55e-04 0.3290 -0.156000 -0.266000 0.115000 2.25e-02 9.58e-05 9.29e-02
Oxidative Stress Induced Senescence 79 1.62e-06 1.02e-05 0.3280 0.270000 0.067600 -0.173000 3.35e-05 2.99e-01 7.96e-03
Regulation of lipid metabolism by PPARalpha 106 1.04e-04 3.91e-04 0.3270 0.254000 0.206000 0.004900 6.09e-06 2.49e-04 9.30e-01
Telomere Extension By Telomerase 23 6.36e-02 9.85e-02 0.3270 -0.126000 -0.302000 -0.012300 2.96e-01 1.23e-02 9.19e-01
NR1H2 and NR1H3-mediated signaling 39 1.40e-02 2.67e-02 0.3270 0.192000 0.147000 -0.219000 3.77e-02 1.12e-01 1.78e-02
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 8.12e-05 3.11e-04 0.3260 0.318000 -0.056400 -0.048400 3.06e-03 5.99e-01 6.52e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 4.43e-03 9.87e-03 0.3260 0.267000 0.087300 0.166000 5.59e-03 3.64e-01 8.47e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 3.97e-02 6.70e-02 0.3260 0.185000 0.209000 -0.169000 6.54e-02 3.79e-02 9.37e-02
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 7.67e-10 9.33e-09 0.3260 0.263000 0.067400 -0.180000 4.20e-07 1.95e-01 5.26e-04
Activation of BAD and translocation to mitochondria 15 1.18e-01 1.67e-01 0.3260 0.310000 0.083900 -0.050800 3.73e-02 5.74e-01 7.33e-01
G alpha (z) signalling events 36 5.25e-03 1.13e-02 0.3250 0.275000 0.082900 -0.153000 4.27e-03 3.89e-01 1.13e-01
E3 ubiquitin ligases ubiquitinate target proteins 52 1.08e-06 7.18e-06 0.3250 0.322000 0.004670 -0.041500 5.75e-05 9.54e-01 6.04e-01
Resolution of Sister Chromatid Cohesion 104 4.06e-11 6.00e-10 0.3240 -0.007230 -0.207000 0.249000 8.99e-01 2.57e-04 1.13e-05
Activation of NF-kappaB in B cells 65 4.35e-05 1.77e-04 0.3240 0.307000 0.104000 0.015800 1.91e-05 1.49e-01 8.26e-01
Other semaphorin interactions 16 1.96e-01 2.50e-01 0.3240 0.165000 0.102000 -0.259000 2.53e-01 4.80e-01 7.27e-02
Surfactant metabolism 21 8.67e-02 1.28e-01 0.3230 0.300000 0.120000 -0.004200 1.75e-02 3.41e-01 9.73e-01
Respiratory electron transport 101 5.60e-08 4.80e-07 0.3220 0.265000 0.067100 -0.170000 4.04e-06 2.44e-01 3.11e-03
G-protein mediated events 44 5.45e-03 1.16e-02 0.3210 0.252000 0.115000 -0.162000 3.80e-03 1.86e-01 6.30e-02
p38MAPK events 13 2.56e-01 3.17e-01 0.3210 0.298000 0.118000 0.006780 6.29e-02 4.60e-01 9.66e-01
Role of phospholipids in phagocytosis 88 9.67e-07 6.52e-06 0.3210 -0.109000 -0.296000 0.058900 7.72e-02 1.63e-06 3.40e-01
SCF-beta-TrCP mediated degradation of Emi1 53 9.57e-05 3.62e-04 0.3200 0.302000 0.076000 0.072000 1.41e-04 3.39e-01 3.65e-01
IRE1alpha activates chaperones 49 5.08e-03 1.10e-02 0.3190 0.268000 0.138000 -0.106000 1.19e-03 9.38e-02 1.98e-01
RUNX3 regulates NOTCH signaling 14 3.49e-01 4.10e-01 0.3190 0.204000 0.181000 -0.167000 1.87e-01 2.42e-01 2.79e-01
Diseases of programmed cell death 27 2.52e-02 4.45e-02 0.3190 0.294000 0.092500 -0.081900 8.11e-03 4.05e-01 4.61e-01
Dual Incision in GG-NER 41 1.88e-02 3.47e-02 0.3190 -0.165000 -0.266000 0.060800 6.73e-02 3.19e-03 5.01e-01
Constitutive Signaling by EGFRvIII 14 8.14e-02 1.21e-01 0.3180 0.288000 0.034200 0.132000 6.23e-02 8.25e-01 3.92e-01
Signaling by EGFRvIII in Cancer 14 8.14e-02 1.21e-01 0.3180 0.288000 0.034200 0.132000 6.23e-02 8.25e-01 3.92e-01
Protein ubiquitination 72 2.69e-09 3.03e-08 0.3180 0.317000 -0.005970 -0.025100 3.21e-06 9.30e-01 7.12e-01
Ca-dependent events 29 3.31e-02 5.68e-02 0.3180 0.246000 0.097400 -0.177000 2.19e-02 3.64e-01 9.85e-02
Tryptophan catabolism 12 5.18e-01 5.66e-01 0.3180 0.225000 0.194000 0.113000 1.77e-01 2.45e-01 4.98e-01
Intrinsic Pathway of Fibrin Clot Formation 16 5.10e-02 8.19e-02 0.3180 0.269000 -0.004110 -0.169000 6.22e-02 9.77e-01 2.43e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 5.53e-03 1.18e-02 0.3180 0.291000 0.073500 -0.105000 3.36e-03 4.58e-01 2.89e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.49e-02 1.13e-01 0.3170 -0.080000 -0.302000 0.055700 5.68e-01 3.10e-02 6.91e-01
Signaling by Receptor Tyrosine Kinases 411 5.36e-24 1.78e-22 0.3170 0.261000 0.122000 -0.133000 1.01e-19 2.12e-05 3.98e-06
Mitophagy 28 1.16e-04 4.31e-04 0.3170 0.184000 -0.197000 -0.167000 9.21e-02 7.11e-02 1.26e-01
Opioid Signalling 75 4.09e-05 1.68e-04 0.3170 0.287000 0.110000 -0.076300 1.69e-05 9.89e-02 2.54e-01
SUMOylation of DNA damage response and repair proteins 77 2.47e-04 8.23e-04 0.3170 -0.161000 -0.252000 0.105000 1.45e-02 1.33e-04 1.13e-01
CLEC7A (Dectin-1) signaling 96 1.91e-08 1.81e-07 0.3170 0.309000 0.070200 -0.002880 1.70e-07 2.35e-01 9.61e-01
Stabilization of p53 54 8.72e-04 2.44e-03 0.3160 0.284000 0.113000 0.081100 3.01e-04 1.51e-01 3.03e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 3.83e-08 3.38e-07 0.3160 -0.062100 -0.305000 0.057300 3.25e-01 1.35e-06 3.64e-01
Programmed Cell Death 178 6.12e-11 8.68e-10 0.3160 0.288000 0.125000 0.034000 3.25e-11 4.04e-03 4.34e-01
Toll Like Receptor 3 (TLR3) Cascade 92 7.25e-07 5.14e-06 0.3160 0.299000 0.094700 -0.038400 7.41e-07 1.16e-01 5.24e-01
TRAF6 mediated IRF7 activation 15 2.57e-01 3.18e-01 0.3150 0.065700 0.190000 0.242000 6.59e-01 2.02e-01 1.05e-01
Interleukin-4 and Interleukin-13 signaling 90 7.39e-10 9.15e-09 0.3150 0.285000 -0.002600 -0.133000 2.91e-06 9.66e-01 2.89e-02
Degradation of AXIN 53 7.61e-04 2.18e-03 0.3140 0.290000 0.106000 0.061000 2.66e-04 1.83e-01 4.42e-01
Formation of tubulin folding intermediates by CCT/TriC 22 4.90e-04 1.46e-03 0.3140 0.289000 -0.111000 -0.053100 1.91e-02 3.66e-01 6.66e-01
FGFR1 mutant receptor activation 23 1.76e-01 2.29e-01 0.3140 0.248000 0.161000 0.104000 3.92e-02 1.81e-01 3.88e-01
Resolution of D-Loop Structures 33 1.91e-02 3.52e-02 0.3130 -0.178000 -0.058300 0.250000 7.61e-02 5.63e-01 1.28e-02
RA biosynthesis pathway 13 5.18e-01 5.66e-01 0.3130 -0.231000 -0.206000 -0.049300 1.50e-01 1.99e-01 7.58e-01
Signaling by Non-Receptor Tyrosine Kinases 48 8.46e-04 2.38e-03 0.3130 0.277000 0.074200 -0.125000 9.02e-04 3.74e-01 1.35e-01
Signaling by PTK6 48 8.46e-04 2.38e-03 0.3130 0.277000 0.074200 -0.125000 9.02e-04 3.74e-01 1.35e-01
SUMOylation of chromatin organization proteins 57 1.79e-03 4.50e-03 0.3120 -0.141000 -0.273000 0.053800 6.50e-02 3.61e-04 4.83e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 3.53e-02 6.01e-02 0.3120 0.274000 -0.098900 -0.112000 1.01e-01 5.53e-01 5.02e-01
Acyl chain remodelling of PC 19 3.33e-01 3.93e-01 0.3110 0.234000 0.193000 0.072300 7.80e-02 1.46e-01 5.85e-01
Asparagine N-linked glycosylation 269 7.29e-14 1.50e-12 0.3100 0.276000 0.143000 0.006900 6.90e-15 5.62e-05 8.46e-01
TGF-beta receptor signaling activates SMADs 32 4.62e-04 1.39e-03 0.3090 0.270000 -0.043200 -0.144000 8.14e-03 6.72e-01 1.58e-01
TRAF6 mediated NF-kB activation 23 1.32e-01 1.84e-01 0.3090 0.270000 0.137000 -0.058900 2.48e-02 2.56e-01 6.25e-01
HSF1-dependent transactivation 29 9.02e-03 1.83e-02 0.3080 0.123000 -0.094100 -0.266000 2.51e-01 3.80e-01 1.30e-02
Keratinization 32 1.44e-02 2.73e-02 0.3080 0.261000 0.069900 -0.149000 1.07e-02 4.94e-01 1.45e-01
Citric acid cycle (TCA cycle) 22 1.77e-01 2.30e-01 0.3080 0.269000 0.150000 0.009440 2.92e-02 2.23e-01 9.39e-01
Tight junction interactions 18 5.41e-02 8.62e-02 0.3070 0.005470 -0.252000 -0.176000 9.68e-01 6.39e-02 1.97e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 4.05e-01 4.60e-01 0.3070 0.246000 0.183000 0.014200 8.85e-02 2.04e-01 9.22e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 1.09e-01 1.55e-01 0.3060 0.159000 -0.150000 -0.214000 3.60e-01 3.89e-01 2.19e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 1.13e-07 9.03e-07 0.3050 -0.038900 -0.197000 0.230000 5.21e-01 1.19e-03 1.49e-04
Amplification of signal from the kinetochores 91 1.13e-07 9.03e-07 0.3050 -0.038900 -0.197000 0.230000 5.21e-01 1.19e-03 1.49e-04
NOTCH3 Intracellular Domain Regulates Transcription 20 1.38e-01 1.89e-01 0.3050 0.257000 0.102000 -0.128000 4.69e-02 4.28e-01 3.20e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 4.32e-04 1.33e-03 0.3050 0.289000 -0.077500 -0.058300 1.08e-02 4.94e-01 6.07e-01
SARS-CoV-2 Infection 63 2.25e-04 7.62e-04 0.3040 0.267000 0.083600 -0.120000 2.49e-04 2.51e-01 9.83e-02
Platelet homeostasis 68 9.61e-04 2.66e-03 0.3040 0.270000 0.132000 -0.045500 1.20e-04 5.92e-02 5.16e-01
Signaling by SCF-KIT 40 5.75e-02 9.05e-02 0.3040 0.245000 0.175000 -0.040300 7.31e-03 5.58e-02 6.59e-01
Metabolism of RNA 685 4.61e-45 3.31e-43 0.3040 -0.088600 -0.286000 -0.051800 7.79e-05 2.51e-37 2.09e-02
Signaling by VEGF 97 5.75e-05 2.31e-04 0.3030 0.254000 0.136000 -0.093600 1.50e-05 2.10e-02 1.11e-01
Signaling by Hippo 18 2.62e-01 3.21e-01 0.3030 0.235000 0.137000 0.133000 8.42e-02 3.16e-01 3.27e-01
Attenuation phase 23 6.02e-03 1.27e-02 0.3030 0.208000 -0.097700 -0.197000 8.35e-02 4.17e-01 1.03e-01
Apoptosis 166 8.90e-10 1.07e-08 0.3020 0.279000 0.113000 0.027900 5.85e-10 1.21e-02 5.36e-01
Heme biosynthesis 14 1.89e-01 2.42e-01 0.3010 0.242000 0.042800 -0.174000 1.17e-01 7.81e-01 2.61e-01
Transport of Mature Transcript to Cytoplasm 81 1.47e-04 5.27e-04 0.3010 -0.136000 -0.232000 0.134000 3.49e-02 3.01e-04 3.67e-02
Chromosome Maintenance 105 2.44e-06 1.47e-05 0.3010 -0.108000 -0.279000 -0.031500 5.64e-02 7.94e-07 5.77e-01
Transcriptional regulation of white adipocyte differentiation 77 1.15e-03 3.10e-03 0.3000 0.250000 0.150000 -0.071800 1.48e-04 2.26e-02 2.76e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 1.79e-07 1.37e-06 0.3000 0.293000 0.054700 0.034000 2.22e-06 3.78e-01 5.83e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 4.19e-01 4.74e-01 0.3000 -0.193000 -0.144000 -0.179000 2.11e-01 3.51e-01 2.45e-01
Glycosaminoglycan metabolism 92 4.84e-05 1.95e-04 0.3000 0.149000 0.113000 -0.235000 1.33e-02 6.21e-02 9.88e-05
Arachidonic acid metabolism 43 1.41e-02 2.68e-02 0.3000 0.191000 0.102000 -0.207000 3.04e-02 2.45e-01 1.86e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 4.85e-03 1.06e-02 0.3000 0.255000 0.120000 -0.101000 1.30e-03 1.31e-01 2.01e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 4.85e-03 1.06e-02 0.3000 0.255000 0.120000 -0.101000 1.30e-03 1.31e-01 2.01e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 4.85e-03 1.06e-02 0.3000 0.255000 0.120000 -0.101000 1.30e-03 1.31e-01 2.01e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 4.85e-03 1.06e-02 0.3000 0.255000 0.120000 -0.101000 1.30e-03 1.31e-01 2.01e-01
Signaling by NOTCH1 in Cancer 53 4.85e-03 1.06e-02 0.3000 0.255000 0.120000 -0.101000 1.30e-03 1.31e-01 2.01e-01
Intra-Golgi traffic 43 5.99e-02 9.35e-02 0.2990 0.227000 0.187000 -0.051000 1.00e-02 3.37e-02 5.63e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 179 5.04e-09 5.54e-08 0.2980 0.268000 0.130000 0.004300 5.92e-10 2.66e-03 9.21e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.22e-02 5.55e-02 0.2980 -0.027600 -0.225000 0.193000 8.27e-01 7.38e-02 1.26e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.22e-02 5.55e-02 0.2980 -0.027600 -0.225000 0.193000 8.27e-01 7.38e-02 1.26e-01
TNFs bind their physiological receptors 25 6.65e-02 1.02e-01 0.2980 -0.082000 -0.268000 -0.100000 4.78e-01 2.02e-02 3.86e-01
Signaling by Interleukins 383 1.59e-21 4.43e-20 0.2980 0.270000 0.108000 -0.062400 9.51e-20 2.84e-04 3.61e-02
GRB2 events in ERBB2 signaling 11 3.45e-02 5.90e-02 0.2980 0.244000 -0.155000 -0.070200 1.61e-01 3.73e-01 6.87e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 5.16e-01 5.66e-01 0.2980 0.224000 0.195000 -0.015900 1.46e-01 2.06e-01 9.18e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 8.34e-05 3.19e-04 0.2970 0.265000 0.089300 0.102000 1.04e-04 1.90e-01 1.35e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 2.06e-04 7.07e-04 0.2970 0.276000 0.088200 0.064100 1.35e-04 2.22e-01 3.75e-01
Signaling by NODAL 13 3.70e-01 4.27e-01 0.2960 -0.048400 -0.152000 -0.250000 7.63e-01 3.43e-01 1.19e-01
Activation of HOX genes during differentiation 68 1.19e-04 4.40e-04 0.2960 0.199000 0.034800 -0.216000 4.46e-03 6.20e-01 2.05e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 1.19e-04 4.40e-04 0.2960 0.199000 0.034800 -0.216000 4.46e-03 6.20e-01 2.05e-03
MAPK6/MAPK4 signaling 81 5.26e-06 2.92e-05 0.2960 0.280000 0.072700 0.063000 1.36e-05 2.58e-01 3.27e-01
APC/C:Cdc20 mediated degradation of Securin 66 1.09e-04 4.08e-04 0.2960 0.269000 0.079300 0.092400 1.54e-04 2.66e-01 1.94e-01
Sphingolipid metabolism 78 2.20e-03 5.37e-03 0.2950 0.238000 0.160000 -0.070200 2.87e-04 1.45e-02 2.84e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 3.90e-02 6.59e-02 0.2950 0.272000 0.108000 -0.037500 7.77e-03 2.91e-01 7.13e-01
NOTCH2 intracellular domain regulates transcription 11 4.99e-01 5.51e-01 0.2940 0.146000 0.249000 -0.055400 4.00e-01 1.52e-01 7.50e-01
Hedgehog ‘on’ state 75 4.59e-04 1.39e-03 0.2940 0.267000 0.121000 0.022000 6.36e-05 7.01e-02 7.42e-01
Oncogene Induced Senescence 33 7.82e-02 1.17e-01 0.2930 0.226000 0.139000 -0.125000 2.44e-02 1.68e-01 2.14e-01
CaM pathway 27 4.72e-02 7.63e-02 0.2930 0.198000 0.039500 -0.213000 7.51e-02 7.23e-01 5.57e-02
Calmodulin induced events 27 4.72e-02 7.63e-02 0.2930 0.198000 0.039500 -0.213000 7.51e-02 7.23e-01 5.57e-02
Binding and Uptake of Ligands by Scavenger Receptors 91 5.41e-11 7.84e-10 0.2920 0.022500 -0.272000 0.106000 7.10e-01 7.45e-06 8.07e-02
Misspliced GSK3beta mutants stabilize beta-catenin 15 1.34e-01 1.85e-01 0.2920 0.287000 0.053600 0.011000 5.40e-02 7.19e-01 9.41e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 1.34e-01 1.85e-01 0.2920 0.287000 0.053600 0.011000 5.40e-02 7.19e-01 9.41e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 1.34e-01 1.85e-01 0.2920 0.287000 0.053600 0.011000 5.40e-02 7.19e-01 9.41e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 1.34e-01 1.85e-01 0.2920 0.287000 0.053600 0.011000 5.40e-02 7.19e-01 9.41e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 1.34e-01 1.85e-01 0.2920 0.287000 0.053600 0.011000 5.40e-02 7.19e-01 9.41e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 1.34e-01 1.85e-01 0.2920 0.287000 0.053600 0.011000 5.40e-02 7.19e-01 9.41e-01
CLEC7A (Dectin-1) induces NFAT activation 11 2.16e-01 2.73e-01 0.2920 -0.035300 -0.288000 -0.036500 8.39e-01 9.81e-02 8.34e-01
Vesicle-mediated transport 646 6.88e-33 2.84e-31 0.2920 0.268000 0.117000 0.001080 2.66e-31 4.07e-07 9.63e-01
CDT1 association with the CDC6:ORC:origin complex 57 1.82e-04 6.30e-04 0.2920 0.259000 0.056100 0.123000 7.05e-04 4.64e-01 1.09e-01
Receptor Mediated Mitophagy 11 1.76e-01 2.29e-01 0.2920 0.289000 0.020200 0.037800 9.70e-02 9.08e-01 8.28e-01
Nuclear Envelope Breakdown 53 1.17e-03 3.16e-03 0.2920 -0.092600 -0.245000 0.129000 2.44e-01 2.06e-03 1.05e-01
Glutathione conjugation 26 2.60e-01 3.20e-01 0.2910 0.175000 0.218000 0.079800 1.22e-01 5.46e-02 4.81e-01
Mitotic Spindle Checkpoint 108 2.42e-08 2.23e-07 0.2900 -0.032300 -0.185000 0.222000 5.62e-01 9.21e-04 6.73e-05
SHC1 events in ERBB2 signaling 17 1.13e-01 1.60e-01 0.2900 0.279000 0.052800 -0.062400 4.67e-02 7.06e-01 6.56e-01
EML4 and NUDC in mitotic spindle formation 95 6.93e-08 5.79e-07 0.2900 -0.020200 -0.193000 0.216000 7.34e-01 1.17e-03 2.75e-04
ZBP1(DAI) mediated induction of type I IFNs 20 2.96e-01 3.56e-01 0.2900 0.190000 0.177000 -0.130000 1.42e-01 1.71e-01 3.15e-01
cGMP effects 12 2.79e-01 3.39e-01 0.2890 0.242000 0.043800 -0.153000 1.47e-01 7.93e-01 3.60e-01
Extracellular matrix organization 216 1.12e-10 1.48e-09 0.2880 0.183000 0.093800 -0.202000 3.69e-06 1.75e-02 3.31e-07
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.78e-02 3.30e-02 0.2870 0.246000 0.148000 0.008170 1.62e-03 5.76e-02 9.17e-01
PKA-mediated phosphorylation of CREB 17 1.03e-01 1.48e-01 0.2860 0.185000 -0.033900 -0.216000 1.86e-01 8.09e-01 1.24e-01
SARS-CoV-1 Infection 47 1.16e-02 2.28e-02 0.2860 0.244000 0.104000 -0.109000 3.87e-03 2.18e-01 1.97e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 16 3.21e-01 3.80e-01 0.2850 -0.135000 -0.213000 0.134000 3.51e-01 1.40e-01 3.52e-01
Telomere Maintenance 80 2.57e-05 1.15e-04 0.2850 -0.045900 -0.249000 -0.132000 4.77e-01 1.20e-04 4.11e-02
PRC2 methylates histones and DNA 29 9.97e-03 1.99e-02 0.2850 0.191000 -0.047800 -0.206000 7.46e-02 6.56e-01 5.47e-02
Macroautophagy 110 3.44e-07 2.50e-06 0.2850 0.271000 0.073100 -0.046300 8.72e-07 1.85e-01 4.01e-01
Regulation of RAS by GAPs 66 1.55e-03 3.98e-03 0.2850 0.252000 0.110000 0.075000 4.06e-04 1.21e-01 2.92e-01
Polo-like kinase mediated events 15 2.27e-02 4.07e-02 0.2840 0.108000 -0.208000 0.161000 4.70e-01 1.63e-01 2.80e-01
DNA Damage Bypass 47 3.63e-03 8.27e-03 0.2840 -0.091100 -0.254000 0.091000 2.80e-01 2.64e-03 2.81e-01
C-type lectin receptors (CLRs) 128 5.82e-07 4.17e-06 0.2840 0.265000 0.102000 0.013700 2.31e-07 4.61e-02 7.89e-01
PI3K events in ERBB2 signaling 11 8.22e-02 1.22e-01 0.2840 0.247000 -0.097700 -0.098900 1.55e-01 5.75e-01 5.70e-01
Inwardly rectifying K+ channels 23 2.81e-01 3.41e-01 0.2840 0.222000 0.154000 0.084600 6.49e-02 2.00e-01 4.83e-01
ESR-mediated signaling 160 1.29e-14 2.79e-13 0.2830 0.238000 -0.027100 -0.152000 2.13e-07 5.54e-01 8.99e-04
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 2.40e-02 4.28e-02 0.2830 0.279000 -0.031200 -0.035200 4.02e-02 8.19e-01 7.96e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 2.40e-02 4.28e-02 0.2830 0.279000 -0.031200 -0.035200 4.02e-02 8.19e-01 7.96e-01
Regulation of insulin secretion 60 5.45e-03 1.16e-02 0.2830 0.253000 0.122000 -0.036300 7.09e-04 1.02e-01 6.27e-01
Signaling by FGFR3 31 1.39e-02 2.65e-02 0.2830 0.273000 0.047200 -0.056700 8.56e-03 6.49e-01 5.85e-01
Extra-nuclear estrogen signaling 66 1.39e-06 8.89e-06 0.2820 0.234000 -0.045600 -0.150000 9.85e-04 5.22e-01 3.48e-02
HS-GAG biosynthesis 20 1.42e-01 1.95e-01 0.2820 0.169000 0.024200 -0.225000 1.91e-01 8.51e-01 8.21e-02
Negative regulation of FGFR2 signaling 23 4.46e-02 7.29e-02 0.2820 0.213000 -0.006220 -0.185000 7.73e-02 9.59e-01 1.25e-01
Viral Messenger RNA Synthesis 44 2.64e-02 4.63e-02 0.2820 -0.129000 -0.249000 0.028400 1.39e-01 4.26e-03 7.45e-01
Asymmetric localization of PCP proteins 60 3.09e-03 7.23e-03 0.2820 0.259000 0.108000 -0.021200 5.14e-04 1.47e-01 7.76e-01
Activation of gene expression by SREBF (SREBP) 42 4.29e-02 7.10e-02 0.2820 0.236000 0.130000 -0.081600 8.13e-03 1.45e-01 3.60e-01
Transport of bile salts and organic acids, metal ions and amine compounds 54 4.20e-02 6.99e-02 0.2810 0.221000 0.173000 -0.022800 5.00e-03 2.79e-02 7.72e-01
Signaling by FGFR4 31 9.15e-03 1.84e-02 0.2810 0.258000 0.017200 -0.111000 1.30e-02 8.69e-01 2.83e-01
Metalloprotease DUBs 21 8.83e-02 1.30e-01 0.2810 0.267000 0.066400 0.059100 3.43e-02 5.99e-01 6.39e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 2.86e-06 1.69e-05 0.2810 0.239000 0.017400 0.147000 3.71e-04 7.96e-01 2.93e-02
Striated Muscle Contraction 23 2.34e-01 2.92e-01 0.2810 0.238000 0.138000 -0.060300 4.86e-02 2.53e-01 6.16e-01
Interferon Signaling 177 9.79e-09 1.03e-07 0.2810 -0.155000 -0.073400 0.223000 3.74e-04 9.22e-02 3.20e-07
Phase 4 - resting membrane potential 10 6.52e-01 6.93e-01 0.2810 0.133000 0.190000 0.158000 4.66e-01 2.97e-01 3.87e-01
Signalling to RAS 18 1.34e-01 1.85e-01 0.2810 0.269000 0.067100 0.042000 4.79e-02 6.22e-01 7.58e-01
RIP-mediated NFkB activation via ZBP1 17 4.00e-01 4.56e-01 0.2810 0.195000 0.160000 -0.123000 1.63e-01 2.53e-01 3.81e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 3.63e-01 4.22e-01 0.2810 -0.147000 -0.229000 0.066400 2.93e-01 1.02e-01 6.35e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 2.78e-06 1.65e-05 0.2800 0.242000 0.019800 0.141000 2.98e-04 7.67e-01 3.49e-02
Mitochondrial translation elongation 91 8.02e-08 6.54e-07 0.2800 -0.011100 -0.269000 -0.076300 8.55e-01 9.21e-06 2.09e-01
FCGR3A-mediated IL10 synthesis 99 9.93e-07 6.67e-06 0.2790 -0.072400 -0.265000 0.053100 2.13e-01 5.36e-06 3.62e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 5.10e-06 2.85e-05 0.2790 0.244000 0.020600 0.134000 3.43e-04 7.62e-01 4.94e-02
Regulation of TP53 Activity through Methylation 19 3.30e-01 3.91e-01 0.2780 -0.120000 -0.128000 -0.216000 3.66e-01 3.33e-01 1.04e-01
RET signaling 32 1.24e-01 1.73e-01 0.2780 0.198000 0.140000 -0.136000 5.27e-02 1.70e-01 1.84e-01
Nucleobase catabolism 28 1.30e-01 1.81e-01 0.2780 0.247000 0.121000 -0.039700 2.37e-02 2.69e-01 7.16e-01
RAS processing 19 6.21e-03 1.30e-02 0.2780 0.126000 -0.236000 -0.073200 3.40e-01 7.49e-02 5.81e-01
Initiation of Nuclear Envelope (NE) Reformation 19 7.77e-02 1.17e-01 0.2770 0.255000 0.034300 0.103000 5.41e-02 7.96e-01 4.35e-01
Acyl chain remodelling of PG 11 4.45e-01 5.00e-01 0.2770 0.175000 0.067900 0.204000 3.14e-01 6.96e-01 2.42e-01
NOTCH4 Intracellular Domain Regulates Transcription 17 2.61e-01 3.21e-01 0.2770 0.106000 0.194000 -0.168000 4.51e-01 1.66e-01 2.32e-01
Tie2 Signaling 16 2.52e-01 3.12e-01 0.2770 0.260000 0.088900 0.034900 7.23e-02 5.38e-01 8.09e-01
Signaling by PDGFR in disease 19 8.65e-02 1.28e-01 0.2770 0.169000 -0.005950 0.219000 2.03e-01 9.64e-01 9.82e-02
RNA Polymerase I Transcription Termination 27 1.18e-01 1.67e-01 0.2760 -0.119000 -0.238000 0.072300 2.84e-01 3.23e-02 5.15e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 8.06e-06 4.27e-05 0.2750 0.245000 0.021600 0.124000 3.54e-04 7.53e-01 7.13e-02
Apoptotic execution phase 45 3.65e-02 6.21e-02 0.2750 0.242000 0.126000 0.036300 4.98e-03 1.43e-01 6.74e-01
Synthesis of very long-chain fatty acyl-CoAs 21 9.26e-02 1.36e-01 0.2750 0.200000 0.033900 0.186000 1.13e-01 7.88e-01 1.40e-01
The citric acid (TCA) cycle and respiratory electron transport 172 3.31e-10 4.25e-09 0.2750 0.239000 0.056700 -0.124000 6.56e-08 2.00e-01 5.18e-03
Norepinephrine Neurotransmitter Release Cycle 13 4.03e-01 4.59e-01 0.2750 -0.033800 -0.163000 -0.218000 8.33e-01 3.08e-01 1.73e-01
Disorders of Developmental Biology 12 3.82e-01 4.37e-01 0.2740 0.180000 0.036100 -0.203000 2.79e-01 8.29e-01 2.22e-01
Disorders of Nervous System Development 12 3.82e-01 4.37e-01 0.2740 0.180000 0.036100 -0.203000 2.79e-01 8.29e-01 2.22e-01
Loss of function of MECP2 in Rett syndrome 12 3.82e-01 4.37e-01 0.2740 0.180000 0.036100 -0.203000 2.79e-01 8.29e-01 2.22e-01
Pervasive developmental disorders 12 3.82e-01 4.37e-01 0.2740 0.180000 0.036100 -0.203000 2.79e-01 8.29e-01 2.22e-01
Deadenylation-dependent mRNA decay 53 4.63e-05 1.88e-04 0.2740 -0.010200 -0.263000 0.078500 8.97e-01 9.42e-04 3.23e-01
Signaling by NOTCH2 30 9.76e-02 1.42e-01 0.2740 0.116000 0.123000 -0.215000 2.72e-01 2.42e-01 4.14e-02
Estrogen-dependent gene expression 98 1.36e-08 1.38e-07 0.2730 0.215000 -0.043700 -0.164000 2.41e-04 4.55e-01 5.12e-03
Nef mediated downregulation of MHC class I complex cell surface expression 10 2.79e-01 3.38e-01 0.2730 0.172000 -0.072200 -0.199000 3.45e-01 6.93e-01 2.77e-01
CDK-mediated phosphorylation and removal of Cdc6 71 8.77e-05 3.35e-04 0.2720 0.245000 0.054200 0.107000 3.64e-04 4.30e-01 1.19e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 3.08e-01 3.68e-01 0.2720 0.203000 0.173000 -0.055400 7.89e-02 1.35e-01 6.31e-01
ABC transporters in lipid homeostasis 14 5.79e-01 6.23e-01 0.2710 -0.205000 -0.173000 0.041400 1.85e-01 2.61e-01 7.89e-01
Degradation of beta-catenin by the destruction complex 83 5.67e-05 2.28e-04 0.2710 0.261000 0.074200 -0.007520 3.98e-05 2.43e-01 9.06e-01
Base Excision Repair 58 5.68e-03 1.20e-02 0.2710 -0.063400 -0.209000 -0.160000 4.03e-01 5.83e-03 3.48e-02
SCF(Skp2)-mediated degradation of p27/p21 60 5.04e-04 1.49e-03 0.2710 0.246000 0.056100 0.099500 1.00e-03 4.53e-01 1.83e-01
Downregulation of TGF-beta receptor signaling 26 1.38e-03 3.59e-03 0.2710 0.193000 -0.155000 -0.111000 8.91e-02 1.72e-01 3.28e-01
p75 NTR receptor-mediated signalling 88 4.22e-04 1.30e-03 0.2710 0.197000 0.090600 -0.162000 1.40e-03 1.42e-01 8.65e-03
Listeria monocytogenes entry into host cells 17 3.04e-01 3.63e-01 0.2700 0.243000 0.100000 -0.062900 8.26e-02 4.73e-01 6.53e-01
Signaling by FGFR1 in disease 30 9.94e-02 1.44e-01 0.2700 0.193000 0.091200 0.165000 6.67e-02 3.88e-01 1.17e-01
Translation of structural proteins 28 9.50e-02 1.38e-01 0.2700 0.138000 0.038100 -0.229000 2.06e-01 7.27e-01 3.57e-02
Regulation of HSF1-mediated heat shock response 79 9.20e-05 3.49e-04 0.2700 -0.079900 -0.254000 0.043200 2.20e-01 9.33e-05 5.07e-01
Mitochondrial protein import 64 1.48e-05 7.33e-05 0.2700 0.034300 -0.228000 -0.141000 6.35e-01 1.63e-03 5.16e-02
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 1.50e-01 2.03e-01 0.2690 0.005520 -0.217000 0.159000 9.73e-01 1.75e-01 3.22e-01
SUMOylation of intracellular receptors 25 2.06e-01 2.62e-01 0.2690 0.218000 0.117000 -0.104000 5.90e-02 3.10e-01 3.68e-01
Regulation of Complement cascade 94 3.43e-07 2.50e-06 0.2680 -0.031400 -0.230000 0.134000 5.99e-01 1.14e-04 2.45e-02
Constitutive Signaling by Overexpressed ERBB2 11 2.12e-01 2.69e-01 0.2670 0.246000 -0.003450 0.105000 1.58e-01 9.84e-01 5.46e-01
Integrin cell surface interactions 52 4.99e-03 1.08e-02 0.2670 0.208000 0.050600 -0.160000 9.46e-03 5.28e-01 4.57e-02
Activation of RAC1 11 3.60e-01 4.20e-01 0.2670 0.161000 0.013900 0.213000 3.54e-01 9.36e-01 2.22e-01
Nephrin family interactions 17 2.50e-01 3.09e-01 0.2670 -0.059600 -0.235000 -0.113000 6.71e-01 9.39e-02 4.18e-01
Insulin processing 20 1.04e-01 1.50e-01 0.2670 0.162000 0.003530 0.213000 2.11e-01 9.78e-01 9.92e-02
TICAM1, RIP1-mediated IKK complex recruitment 19 6.49e-02 9.99e-02 0.2670 0.248000 0.010600 0.099800 6.15e-02 9.36e-01 4.52e-01
NCAM1 interactions 23 3.70e-01 4.27e-01 0.2660 -0.180000 -0.190000 0.051100 1.36e-01 1.15e-01 6.72e-01
Mitochondrial translation termination 91 2.76e-07 2.06e-06 0.2660 -0.011800 -0.261000 -0.052000 8.46e-01 1.74e-05 3.91e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 4.55e-01 5.08e-01 0.2660 0.011400 -0.161000 -0.211000 9.50e-01 3.77e-01 2.48e-01
Defective EXT2 causes exostoses 2 10 4.55e-01 5.08e-01 0.2660 0.011400 -0.161000 -0.211000 9.50e-01 3.77e-01 2.48e-01
Beta-catenin independent WNT signaling 136 6.64e-06 3.59e-05 0.2650 0.232000 0.102000 -0.079300 3.06e-06 3.91e-02 1.10e-01
FCERI mediated MAPK activation 90 1.05e-08 1.10e-07 0.2650 0.012200 -0.251000 0.084100 8.41e-01 3.84e-05 1.68e-01
Mitotic Prometaphase 184 1.83e-11 2.80e-10 0.2640 -0.047100 -0.195000 0.172000 2.70e-01 4.86e-06 5.91e-05
Prostacyclin signalling through prostacyclin receptor 16 1.38e-01 1.89e-01 0.2640 0.262000 0.027700 0.005870 6.95e-02 8.48e-01 9.68e-01
Regulation of TP53 Activity through Phosphorylation 88 3.23e-04 1.04e-03 0.2630 -0.093500 -0.156000 0.190000 1.30e-01 1.14e-02 2.01e-03
p53-Dependent G1 DNA Damage Response 63 1.23e-03 3.28e-03 0.2630 0.236000 0.069400 0.093400 1.19e-03 3.41e-01 2.00e-01
p53-Dependent G1/S DNA damage checkpoint 63 1.23e-03 3.28e-03 0.2630 0.236000 0.069400 0.093400 1.19e-03 3.41e-01 2.00e-01
Mitochondrial translation initiation 91 2.54e-07 1.91e-06 0.2630 -0.006320 -0.257000 -0.053900 9.17e-01 2.18e-05 3.75e-01
Signaling by FGFR3 in disease 13 1.44e-01 1.97e-01 0.2630 0.017900 -0.214000 0.152000 9.11e-01 1.82e-01 3.44e-01
Signaling by FGFR3 point mutants in cancer 13 1.44e-01 1.97e-01 0.2630 0.017900 -0.214000 0.152000 9.11e-01 1.82e-01 3.44e-01
Diseases associated with O-glycosylation of proteins 47 3.39e-03 7.79e-03 0.2620 -0.218000 -0.038100 -0.141000 9.67e-03 6.51e-01 9.51e-02
Aggrephagy 22 1.63e-02 3.07e-02 0.2620 0.244000 -0.053000 -0.079300 4.77e-02 6.67e-01 5.19e-01
Maturation of nucleoprotein 10 3.63e-01 4.22e-01 0.2620 -0.169000 0.042000 0.195000 3.53e-01 8.18e-01 2.86e-01
NOD1/2 Signaling Pathway 32 1.10e-01 1.56e-01 0.2610 0.225000 0.105000 0.081600 2.75e-02 3.05e-01 4.25e-01
Regulation of RUNX2 expression and activity 66 4.89e-04 1.46e-03 0.2610 0.233000 0.055400 0.105000 1.08e-03 4.36e-01 1.40e-01
Glycerophospholipid biosynthesis 106 2.45e-04 8.19e-04 0.2610 0.234000 0.111000 -0.030800 3.07e-05 4.81e-02 5.84e-01
Hemostasis 543 3.67e-31 1.47e-29 0.2610 0.243000 0.048500 -0.081100 3.36e-22 5.32e-02 1.23e-03
Mitochondrial iron-sulfur cluster biogenesis 13 1.23e-01 1.73e-01 0.2600 0.254000 -0.023300 0.054300 1.13e-01 8.84e-01 7.35e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 3.84e-04 1.21e-03 0.2600 0.250000 -0.054600 0.044800 9.34e-03 5.71e-01 6.42e-01
RNA Polymerase III Transcription Initiation 36 2.31e-01 2.89e-01 0.2600 -0.172000 -0.191000 -0.041400 7.48e-02 4.74e-02 6.67e-01
Signaling by Activin 10 7.16e-01 7.49e-01 0.2600 -0.140000 -0.210000 -0.061600 4.42e-01 2.50e-01 7.36e-01
Regulation of PTEN gene transcription 59 1.35e-03 3.55e-03 0.2600 0.171000 -0.000569 -0.196000 2.31e-02 9.94e-01 9.31e-03
Basigin interactions 23 9.90e-02 1.43e-01 0.2600 0.061900 -0.117000 -0.224000 6.07e-01 3.31e-01 6.35e-02
Signaling by Nuclear Receptors 216 7.84e-15 1.78e-13 0.2600 0.210000 -0.009470 -0.152000 9.91e-08 8.11e-01 1.20e-04
Carboxyterminal post-translational modifications of tubulin 26 2.98e-01 3.58e-01 0.2590 0.170000 0.171000 -0.095700 1.33e-01 1.31e-01 3.98e-01
PIWI-interacting RNA (piRNA) biogenesis 23 5.71e-02 9.00e-02 0.2590 0.039600 -0.190000 -0.172000 7.42e-01 1.16e-01 1.53e-01
COPI-dependent Golgi-to-ER retrograde traffic 78 2.15e-03 5.26e-03 0.2590 0.229000 0.103000 0.060900 4.61e-04 1.15e-01 3.52e-01
Complement cascade 98 5.99e-07 4.27e-06 0.2590 -0.030500 -0.221000 0.131000 6.02e-01 1.54e-04 2.56e-02
UCH proteinases 86 4.09e-04 1.27e-03 0.2580 0.234000 0.082900 -0.071800 1.81e-04 1.84e-01 2.50e-01
AMER1 mutants destabilize the destruction complex 14 1.68e-01 2.21e-01 0.2580 0.257000 0.009510 -0.018500 9.63e-02 9.51e-01 9.05e-01
APC truncation mutants have impaired AXIN binding 14 1.68e-01 2.21e-01 0.2580 0.257000 0.009510 -0.018500 9.63e-02 9.51e-01 9.05e-01
AXIN missense mutants destabilize the destruction complex 14 1.68e-01 2.21e-01 0.2580 0.257000 0.009510 -0.018500 9.63e-02 9.51e-01 9.05e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 1.68e-01 2.21e-01 0.2580 0.257000 0.009510 -0.018500 9.63e-02 9.51e-01 9.05e-01
Truncations of AMER1 destabilize the destruction complex 14 1.68e-01 2.21e-01 0.2580 0.257000 0.009510 -0.018500 9.63e-02 9.51e-01 9.05e-01
truncated APC mutants destabilize the destruction complex 14 1.68e-01 2.21e-01 0.2580 0.257000 0.009510 -0.018500 9.63e-02 9.51e-01 9.05e-01
Signaling by ERBB4 44 5.07e-03 1.10e-02 0.2570 0.247000 0.037800 -0.059600 4.51e-03 6.64e-01 4.94e-01
G1/S DNA Damage Checkpoints 65 5.83e-04 1.70e-03 0.2570 0.233000 0.052500 0.094500 1.14e-03 4.64e-01 1.87e-01
Interleukin-12 family signaling 53 7.30e-03 1.51e-02 0.2570 0.211000 0.068700 0.130000 7.79e-03 3.87e-01 1.03e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.72e-01 2.25e-01 0.2570 -0.030200 0.157000 -0.202000 8.45e-01 3.09e-01 1.92e-01
Sialic acid metabolism 28 2.95e-01 3.55e-01 0.2570 0.210000 0.147000 0.015400 5.43e-02 1.77e-01 8.88e-01
B-WICH complex positively regulates rRNA expression 44 1.51e-04 5.36e-04 0.2570 0.174000 -0.122000 -0.145000 4.64e-02 1.60e-01 9.68e-02
Chaperone Mediated Autophagy 20 2.46e-02 4.37e-02 0.2570 0.214000 -0.086100 -0.113000 9.77e-02 5.05e-01 3.82e-01
Elastic fibre formation 32 5.23e-02 8.37e-02 0.2560 0.200000 0.036900 -0.155000 4.99e-02 7.18e-01 1.28e-01
Neurexins and neuroligins 36 9.15e-02 1.34e-01 0.2560 -0.066000 -0.068400 -0.238000 4.93e-01 4.78e-01 1.36e-02
Cell junction organization 57 1.32e-03 3.50e-03 0.2560 0.162000 -0.021400 -0.197000 3.45e-02 7.80e-01 1.01e-02
Phase 0 - rapid depolarisation 22 2.14e-01 2.70e-01 0.2560 -0.228000 -0.083600 0.079200 6.38e-02 4.97e-01 5.20e-01
Ion channel transport 131 4.18e-04 1.29e-03 0.2560 0.199000 0.143000 -0.072800 8.28e-05 4.81e-03 1.50e-01
G2/M DNA damage checkpoint 67 7.26e-04 2.09e-03 0.2550 -0.038400 -0.150000 0.203000 5.87e-01 3.41e-02 4.03e-03
TP53 Regulates Metabolic Genes 84 1.19e-03 3.19e-03 0.2550 0.235000 0.098000 -0.020400 2.01e-04 1.21e-01 7.47e-01
RHO GTPase Effectors 249 7.91e-12 1.31e-10 0.2550 0.242000 0.079400 0.013100 4.79e-11 3.10e-02 7.22e-01
HSF1 activation 26 1.32e-02 2.55e-02 0.2550 0.092600 -0.184000 -0.150000 4.14e-01 1.04e-01 1.86e-01
Metabolism of carbohydrates 241 4.52e-09 5.00e-08 0.2540 0.154000 0.090500 -0.181000 3.85e-05 1.56e-02 1.33e-06
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 4.20e-05 1.72e-04 0.2540 -0.135000 -0.194000 -0.091700 1.63e-03 6.07e-06 3.29e-02
Synthesis, secretion, and deacylation of Ghrelin 11 4.24e-01 4.78e-01 0.2530 -0.064100 -0.217000 0.115000 7.13e-01 2.14e-01 5.09e-01
Mitochondrial translation 97 8.29e-08 6.68e-07 0.2530 0.002610 -0.251000 -0.032100 9.65e-01 1.89e-05 5.85e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 3.01e-01 3.60e-01 0.2530 0.163000 0.075600 -0.178000 2.06e-01 5.58e-01 1.68e-01
Trafficking of AMPA receptors 20 3.01e-01 3.60e-01 0.2530 0.163000 0.075600 -0.178000 2.06e-01 5.58e-01 1.68e-01
APC/C-mediated degradation of cell cycle proteins 86 9.33e-07 6.32e-06 0.2530 0.189000 -0.025000 0.167000 2.51e-03 6.89e-01 7.53e-03
Regulation of mitotic cell cycle 86 9.33e-07 6.32e-06 0.2530 0.189000 -0.025000 0.167000 2.51e-03 6.89e-01 7.53e-03
Unblocking of NMDA receptors, glutamate binding and activation 12 6.99e-01 7.33e-01 0.2520 -0.197000 -0.157000 -0.018600 2.37e-01 3.48e-01 9.11e-01
Diseases of signal transduction by growth factor receptors and second messengers 339 2.32e-14 4.94e-13 0.2520 0.233000 0.086000 -0.042200 1.65e-13 6.52e-03 1.82e-01
Metabolism of cofactors 19 4.24e-01 4.78e-01 0.2520 0.191000 0.118000 0.114000 1.50e-01 3.72e-01 3.89e-01
Elevation of cytosolic Ca2+ levels 12 5.45e-01 5.93e-01 0.2510 0.119000 0.078000 -0.207000 4.76e-01 6.40e-01 2.15e-01
Blood group systems biosynthesis 17 1.70e-01 2.23e-01 0.2510 0.150000 -0.053800 -0.193000 2.84e-01 7.01e-01 1.67e-01
PI-3K cascade:FGFR2 12 3.57e-01 4.17e-01 0.2500 -0.053400 -0.233000 0.070400 7.49e-01 1.61e-01 6.73e-01
TCF dependent signaling in response to WNT 165 1.13e-08 1.16e-07 0.2490 0.213000 0.036600 -0.124000 2.30e-06 4.17e-01 6.07e-03
PERK regulates gene expression 30 2.78e-03 6.58e-03 0.2490 0.091400 -0.174000 0.153000 3.86e-01 9.95e-02 1.46e-01
Downstream signaling events of B Cell Receptor (BCR) 79 3.09e-05 1.33e-04 0.2480 0.243000 0.029500 0.036900 1.84e-04 6.51e-01 5.70e-01
Pyruvate metabolism 28 3.77e-02 6.39e-02 0.2470 0.244000 0.027100 0.027600 2.54e-02 8.04e-01 8.00e-01
Signaling by WNT 253 1.77e-11 2.76e-10 0.2460 0.216000 0.059700 -0.101000 3.09e-09 1.02e-01 5.65e-03
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 9.71e-02 1.41e-01 0.2460 -0.107000 -0.220000 0.020100 2.54e-01 1.87e-02 8.30e-01
Phosphorylation of the APC/C 20 8.36e-02 1.24e-01 0.2460 0.044700 -0.137000 0.199000 7.29e-01 2.89e-01 1.23e-01
Interleukin-12 signaling 44 2.97e-02 5.13e-02 0.2450 0.211000 0.070900 0.104000 1.56e-02 4.16e-01 2.32e-01
Cellular response to heat stress 93 1.40e-04 5.06e-04 0.2450 -0.068300 -0.235000 -0.010700 2.55e-01 8.85e-05 8.59e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 1.77e-01 2.30e-01 0.2450 -0.009810 -0.244000 -0.016300 9.48e-01 1.01e-01 9.13e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 5.67e-01 6.11e-01 0.2450 0.129000 0.119000 -0.171000 4.21e-01 4.57e-01 2.86e-01
Processing of Intronless Pre-mRNAs 19 3.41e-01 4.01e-01 0.2450 -0.084900 -0.061700 0.221000 5.22e-01 6.41e-01 9.54e-02
Phase 2 - plateau phase 11 2.94e-01 3.54e-01 0.2440 -0.186000 0.053300 0.149000 2.85e-01 7.60e-01 3.91e-01
ABC-family proteins mediated transport 93 1.65e-04 5.76e-04 0.2440 0.232000 0.068200 0.029800 1.08e-04 2.56e-01 6.19e-01
Regulation of APC/C activators between G1/S and early anaphase 79 2.84e-06 1.68e-05 0.2440 0.202000 -0.026900 0.134000 1.94e-03 6.79e-01 3.91e-02
RIPK1-mediated regulated necrosis 29 4.33e-02 7.14e-02 0.2440 0.231000 0.030800 0.072600 3.16e-02 7.74e-01 4.99e-01
Regulated Necrosis 29 4.33e-02 7.14e-02 0.2440 0.231000 0.030800 0.072600 3.16e-02 7.74e-01 4.99e-01
Regulation of necroptotic cell death 29 4.33e-02 7.14e-02 0.2440 0.231000 0.030800 0.072600 3.16e-02 7.74e-01 4.99e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 5.53e-01 5.99e-01 0.2440 0.099200 0.167000 -0.148000 5.52e-01 3.18e-01 3.76e-01
APC-Cdc20 mediated degradation of Nek2A 26 1.68e-02 3.16e-02 0.2440 0.022400 -0.224000 0.093100 8.43e-01 4.81e-02 4.11e-01
Sphingolipid de novo biosynthesis 42 6.76e-02 1.03e-01 0.2430 0.223000 0.095700 0.012000 1.23e-02 2.83e-01 8.93e-01
Signaling by FGFR1 38 1.83e-01 2.35e-01 0.2430 0.198000 0.131000 -0.051000 3.44e-02 1.62e-01 5.86e-01
TRAF3-dependent IRF activation pathway 13 4.91e-01 5.43e-01 0.2430 0.048400 0.191000 0.141000 7.63e-01 2.33e-01 3.78e-01
Interleukin-7 signaling 21 2.61e-01 3.21e-01 0.2420 0.077700 -0.015000 -0.229000 5.38e-01 9.05e-01 6.92e-02
Assembly and cell surface presentation of NMDA receptors 18 5.11e-01 5.61e-01 0.2420 -0.109000 -0.189000 -0.106000 4.23e-01 1.66e-01 4.37e-01
MHC class II antigen presentation 101 4.32e-03 9.68e-03 0.2420 0.207000 0.125000 0.009920 3.22e-04 3.02e-02 8.63e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.63e-01 2.17e-01 0.2420 0.019200 -0.205000 0.127000 9.01e-01 1.84e-01 4.12e-01
Termination of O-glycan biosynthesis 16 3.59e-01 4.19e-01 0.2420 0.034200 0.092200 -0.221000 8.13e-01 5.23e-01 1.26e-01
MicroRNA (miRNA) biogenesis 24 1.87e-01 2.40e-01 0.2410 0.067600 -0.047100 -0.227000 5.66e-01 6.90e-01 5.43e-02
Synthesis of PE 12 6.60e-01 6.99e-01 0.2410 -0.182000 -0.124000 0.099700 2.76e-01 4.58e-01 5.50e-01
Positive epigenetic regulation of rRNA expression 59 7.01e-05 2.72e-04 0.2410 0.091900 -0.171000 -0.143000 2.22e-01 2.34e-02 5.82e-02
PTEN Regulation 138 1.99e-05 9.34e-05 0.2400 0.219000 0.082700 -0.055800 9.05e-06 9.35e-02 2.58e-01
FOXO-mediated transcription of cell cycle genes 15 2.30e-01 2.88e-01 0.2400 0.011900 -0.208000 -0.120000 9.37e-01 1.64e-01 4.20e-01
S Phase 160 2.13e-09 2.43e-08 0.2400 -0.032200 -0.203000 0.124000 4.82e-01 9.33e-06 6.61e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 2.00e-01 2.54e-01 0.2400 0.236000 0.038500 -0.015400 8.25e-02 7.77e-01 9.10e-01
SUMOylation of transcription factors 16 5.46e-01 5.93e-01 0.2400 0.132000 0.108000 0.169000 3.61e-01 4.54e-01 2.42e-01
Interleukin-6 family signaling 18 4.07e-01 4.63e-01 0.2400 0.205000 0.091300 -0.083900 1.31e-01 5.03e-01 5.38e-01
Signaling by ERBB2 in Cancer 21 1.35e-02 2.59e-02 0.2400 0.217000 -0.095900 0.034800 8.51e-02 4.47e-01 7.83e-01
Signaling by FGFR4 in disease 11 2.36e-01 2.95e-01 0.2400 0.064700 -0.161000 0.165000 7.10e-01 3.55e-01 3.42e-01
Formation of Incision Complex in GG-NER 43 2.79e-03 6.59e-03 0.2400 0.037900 -0.149000 0.183000 6.67e-01 8.99e-02 3.76e-02
N-glycan antennae elongation in the medial/trans-Golgi 21 3.31e-01 3.91e-01 0.2390 -0.026800 -0.114000 -0.209000 8.31e-01 3.67e-01 9.78e-02
Endosomal/Vacuolar pathway 12 6.46e-01 6.88e-01 0.2390 -0.098900 -0.101000 -0.193000 5.53e-01 5.46e-01 2.47e-01
Chaperonin-mediated protein folding 84 3.10e-04 1.00e-03 0.2370 0.229000 0.052000 -0.036400 2.89e-04 4.10e-01 5.64e-01
RNA Polymerase III Transcription Termination 23 1.67e-01 2.21e-01 0.2370 -0.043500 -0.222000 -0.068900 7.18e-01 6.52e-02 5.67e-01
Non-integrin membrane-ECM interactions 37 8.01e-03 1.64e-02 0.2370 0.111000 -0.123000 -0.169000 2.44e-01 1.96e-01 7.52e-02
Metabolism of amino acids and derivatives 322 1.12e-16 2.67e-15 0.2360 -0.004800 -0.199000 -0.127000 8.82e-01 8.66e-10 8.50e-05
Potassium Channels 62 4.44e-02 7.26e-02 0.2350 0.119000 0.203000 -0.008360 1.06e-01 5.69e-03 9.09e-01
Pregnenolone biosynthesis 10 5.97e-01 6.40e-01 0.2350 0.063100 0.142000 -0.176000 7.30e-01 4.37e-01 3.35e-01
Cell Cycle Checkpoints 258 4.74e-15 1.09e-13 0.2340 0.015300 -0.137000 0.189000 6.71e-01 1.47e-04 1.77e-07
Cell-Cell communication 85 1.90e-04 6.55e-04 0.2340 0.143000 -0.026600 -0.183000 2.24e-02 6.72e-01 3.57e-03
Cellular Senescence 144 1.37e-06 8.83e-06 0.2340 0.192000 0.032100 -0.130000 7.23e-05 5.06e-01 7.04e-03
Depolymerisation of the Nuclear Lamina 15 1.26e-01 1.77e-01 0.2340 0.231000 -0.035500 -0.006560 1.22e-01 8.12e-01 9.65e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 3.80e-01 4.37e-01 0.2330 -0.082300 -0.214000 0.044500 5.57e-01 1.27e-01 7.51e-01
Cell death signalling via NRAGE, NRIF and NADE 69 1.03e-02 2.05e-02 0.2330 0.138000 0.050900 -0.180000 4.70e-02 4.65e-01 9.55e-03
Stimuli-sensing channels 71 4.37e-02 7.20e-02 0.2320 0.184000 0.128000 -0.060100 7.48e-03 6.23e-02 3.81e-01
Mitochondrial calcium ion transport 22 2.77e-02 4.83e-02 0.2320 0.100000 -0.187000 -0.092800 4.15e-01 1.29e-01 4.51e-01
Fertilization 12 5.98e-01 6.41e-01 0.2310 0.082700 0.089300 -0.196000 6.20e-01 5.92e-01 2.39e-01
Selective autophagy 58 8.96e-05 3.41e-04 0.2310 0.219000 -0.045400 -0.058600 3.98e-03 5.49e-01 4.40e-01
DAG and IP3 signaling 33 1.29e-01 1.80e-01 0.2310 0.117000 0.021600 -0.198000 2.44e-01 8.30e-01 4.96e-02
Separation of Sister Chromatids 167 1.78e-11 2.76e-10 0.2300 0.096200 -0.093500 0.187000 3.19e-02 3.71e-02 2.98e-05
Serotonin Neurotransmitter Release Cycle 14 5.55e-01 6.00e-01 0.2300 -0.040800 -0.139000 -0.178000 7.91e-01 3.67e-01 2.48e-01
Triglyceride metabolism 25 4.47e-01 5.01e-01 0.2300 0.187000 0.131000 0.031000 1.06e-01 2.59e-01 7.89e-01
Signaling by FGFR2 IIIa TM 18 1.50e-01 2.03e-01 0.2300 0.141000 -0.081500 -0.162000 3.02e-01 5.49e-01 2.33e-01
Synaptic adhesion-like molecules 14 5.20e-01 5.68e-01 0.2290 0.070000 0.103000 -0.192000 6.50e-01 5.04e-01 2.14e-01
DAP12 interactions 39 1.58e-01 2.12e-01 0.2270 0.194000 0.097800 -0.067500 3.65e-02 2.91e-01 4.66e-01
Metabolism of steroids 117 3.34e-03 7.68e-03 0.2270 0.189000 0.113000 0.053800 4.00e-04 3.55e-02 3.15e-01
Regulation of TP53 Expression and Degradation 36 2.48e-02 4.40e-02 0.2260 -0.014500 -0.222000 -0.039500 8.80e-01 2.10e-02 6.82e-01
Transport of small molecules 553 1.17e-15 2.75e-14 0.2260 0.193000 0.094700 -0.070600 9.37e-15 1.40e-04 4.55e-03
Voltage gated Potassium channels 24 1.20e-01 1.69e-01 0.2250 0.014800 0.165000 -0.153000 9.00e-01 1.62e-01 1.95e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 1.22e-01 1.71e-01 0.2250 0.050400 -0.053300 -0.213000 6.11e-01 5.91e-01 3.18e-02
Signaling by Rho GTPases 365 1.52e-11 2.44e-10 0.2250 0.207000 0.085500 -0.022800 1.12e-11 5.05e-03 4.54e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 7.91e-04 2.25e-03 0.2240 0.172000 0.007670 -0.144000 7.69e-03 9.06e-01 2.64e-02
Ephrin signaling 17 2.93e-01 3.54e-01 0.2240 0.157000 -0.012500 -0.160000 2.63e-01 9.29e-01 2.53e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 4.09e-01 4.65e-01 0.2240 -0.127000 -0.185000 -0.006470 2.44e-01 9.07e-02 9.53e-01
Bile acid and bile salt metabolism 28 4.20e-01 4.74e-01 0.2240 0.156000 0.125000 0.101000 1.53e-01 2.51e-01 3.53e-01
Cytosolic sulfonation of small molecules 18 5.73e-01 6.17e-01 0.2240 0.124000 0.185000 -0.028700 3.62e-01 1.75e-01 8.33e-01
Regulation of KIT signaling 15 5.53e-01 5.99e-01 0.2240 0.097800 0.110000 -0.169000 5.12e-01 4.62e-01 2.56e-01
DCC mediated attractive signaling 13 3.92e-01 4.48e-01 0.2240 0.001390 -0.191000 -0.118000 9.93e-01 2.34e-01 4.62e-01
Deactivation of the beta-catenin transactivating complex 36 6.42e-02 9.90e-02 0.2240 0.034500 -0.123000 -0.183000 7.20e-01 2.00e-01 5.68e-02
Signaling by ERBB2 TMD/JMD mutants 17 4.69e-02 7.61e-02 0.2240 0.189000 -0.118000 -0.013800 1.77e-01 3.99e-01 9.22e-01
G1/S Transition 130 3.85e-08 3.38e-07 0.2230 0.004980 -0.187000 0.122000 9.22e-01 2.27e-04 1.64e-02
Diseases associated with glycosaminoglycan metabolism 26 2.53e-01 3.13e-01 0.2230 0.091200 0.014600 -0.203000 4.21e-01 8.98e-01 7.26e-02
Transcriptional regulation by RUNX2 100 5.59e-03 1.19e-02 0.2230 0.196000 0.101000 0.035100 6.97e-04 8.18e-02 5.44e-01
Rho GTPase cycle 125 5.15e-03 1.11e-02 0.2230 0.158000 0.138000 -0.075100 2.25e-03 7.52e-03 1.47e-01
DNA Damage/Telomere Stress Induced Senescence 44 5.38e-03 1.15e-02 0.2230 0.190000 -0.034100 -0.111000 2.90e-02 6.96e-01 2.02e-01
DNA Replication 125 3.02e-06 1.75e-05 0.2220 -0.018700 -0.159000 0.153000 7.17e-01 2.09e-03 3.09e-03
Intracellular signaling by second messengers 271 3.67e-10 4.67e-09 0.2210 0.184000 0.043800 -0.116000 1.93e-07 2.14e-01 1.05e-03
NRAGE signals death through JNK 52 5.52e-02 8.74e-02 0.2210 0.069500 0.040200 -0.206000 3.86e-01 6.16e-01 1.01e-02
PIP3 activates AKT signaling 239 3.24e-09 3.61e-08 0.2210 0.192000 0.044800 -0.101000 3.34e-07 2.33e-01 7.04e-03
Nitric oxide stimulates guanylate cyclase 15 3.10e-01 3.68e-01 0.2210 0.184000 -0.008630 -0.123000 2.18e-01 9.54e-01 4.10e-01
Transcriptional regulation by RUNX3 90 8.27e-03 1.69e-02 0.2210 0.200000 0.094500 -0.004300 1.04e-03 1.21e-01 9.44e-01
HATs acetylate histones 93 1.85e-03 4.60e-03 0.2210 -0.016900 -0.144000 -0.167000 7.78e-01 1.63e-02 5.38e-03
PI3K/AKT Signaling in Cancer 80 2.23e-03 5.43e-03 0.2210 0.110000 -0.019400 -0.191000 9.01e-02 7.65e-01 3.14e-03
FGFR2 alternative splicing 25 1.17e-01 1.66e-01 0.2210 0.061700 -0.127000 -0.170000 5.93e-01 2.71e-01 1.42e-01
Processing of DNA double-strand break ends 71 2.13e-03 5.22e-03 0.2210 -0.031300 -0.155000 0.154000 6.48e-01 2.43e-02 2.45e-02
PI-3K cascade:FGFR4 10 2.42e-01 3.00e-01 0.2200 0.104000 -0.187000 -0.052000 5.68e-01 3.07e-01 7.76e-01
Signaling by ERBB2 KD Mutants 20 2.64e-02 4.63e-02 0.2200 0.184000 -0.116000 0.032000 1.54e-01 3.68e-01 8.04e-01
Processing of Capped Intron-Containing Pre-mRNA 238 1.17e-11 1.89e-10 0.2200 -0.035400 -0.213000 0.042500 3.46e-01 1.55e-08 2.59e-01
Synthesis of DNA 118 1.37e-05 6.89e-05 0.2190 -0.031500 -0.171000 0.134000 5.55e-01 1.36e-03 1.18e-02
FGFR2 mutant receptor activation 22 2.00e-01 2.54e-01 0.2190 0.021400 -0.155000 -0.153000 8.62e-01 2.09e-01 2.13e-01
Neurotransmitter receptors and postsynaptic signal transmission 123 3.23e-03 7.48e-03 0.2180 0.172000 0.105000 -0.083800 1.01e-03 4.49e-02 1.09e-01
FRS-mediated FGFR3 signaling 11 2.58e-01 3.18e-01 0.2180 0.188000 -0.062700 0.090400 2.81e-01 7.19e-01 6.04e-01
Signaling by ERBB2 ECD mutants 15 1.13e-01 1.60e-01 0.2180 0.153000 -0.106000 0.114000 3.06e-01 4.77e-01 4.47e-01
RAF-independent MAPK1/3 activation 21 2.84e-01 3.43e-01 0.2170 0.145000 0.006220 -0.162000 2.49e-01 9.61e-01 2.00e-01
Regulation of beta-cell development 19 5.28e-01 5.76e-01 0.2170 0.122000 0.120000 -0.135000 3.58e-01 3.67e-01 3.10e-01
SARS-CoV Infections 139 3.01e-06 1.75e-05 0.2170 0.205000 0.030300 -0.065000 3.00e-05 5.38e-01 1.86e-01
Axon guidance 453 5.40e-20 1.44e-18 0.2170 0.120000 -0.044100 -0.175000 1.17e-05 1.08e-01 1.60e-10
Purine catabolism 16 5.02e-01 5.53e-01 0.2170 0.086900 0.015000 -0.198000 5.47e-01 9.17e-01 1.70e-01
FCERI mediated NF-kB activation 137 8.96e-13 1.60e-11 0.2170 0.106000 -0.176000 0.069600 3.20e-02 3.82e-04 1.60e-01
Signaling by TGF-beta Receptor Complex 72 6.56e-05 2.57e-04 0.2170 0.194000 -0.044300 -0.085400 4.42e-03 5.16e-01 2.10e-01
Protein folding 90 1.34e-03 3.53e-03 0.2160 0.207000 0.054500 -0.033100 7.08e-04 3.71e-01 5.87e-01
Platelet calcium homeostasis 21 5.06e-01 5.56e-01 0.2160 0.140000 0.110000 -0.122000 2.67e-01 3.83e-01 3.33e-01
Inositol phosphate metabolism 42 1.33e-01 1.84e-01 0.2160 0.084400 0.082100 -0.181000 3.44e-01 3.57e-01 4.26e-02
SHC-mediated cascade:FGFR2 12 5.14e-01 5.65e-01 0.2150 -0.042700 -0.167000 0.128000 7.98e-01 3.16e-01 4.42e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 2.58e-01 3.18e-01 0.2140 0.020500 0.114000 -0.180000 8.68e-01 3.54e-01 1.43e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 2.49e-01 3.09e-01 0.2140 0.139000 -0.057000 -0.153000 3.20e-01 6.84e-01 2.76e-01
Immune System 1887 7.63e-51 1.73e-48 0.2140 0.197000 0.079800 -0.024500 9.89e-46 9.95e-09 7.81e-02
Processing of Capped Intronless Pre-mRNA 28 1.58e-01 2.12e-01 0.2140 -0.049200 -0.178000 0.107000 6.52e-01 1.02e-01 3.27e-01
Prolactin receptor signaling 11 2.72e-01 3.31e-01 0.2140 0.082400 -0.151000 0.127000 6.36e-01 3.86e-01 4.67e-01
Purine salvage 12 4.69e-01 5.22e-01 0.2140 0.210000 0.031800 0.022100 2.08e-01 8.49e-01 8.94e-01
Metabolism of lipids 621 9.35e-13 1.65e-11 0.2130 0.179000 0.115000 -0.017400 2.74e-14 9.95e-07 4.59e-01
Regulation of innate immune responses to cytosolic DNA 14 5.28e-01 5.76e-01 0.2130 0.018700 -0.101000 -0.187000 9.03e-01 5.14e-01 2.26e-01
Regulation of TP53 Degradation 35 3.18e-02 5.48e-02 0.2130 0.004450 -0.206000 -0.053300 9.64e-01 3.49e-02 5.85e-01
mRNA Splicing - Minor Pathway 52 2.66e-03 6.34e-03 0.2130 0.045100 -0.179000 -0.106000 5.74e-01 2.56e-02 1.86e-01
Assembly of the pre-replicative complex 66 1.12e-03 3.05e-03 0.2130 0.193000 0.005010 0.090300 6.82e-03 9.44e-01 2.04e-01
Peroxisomal lipid metabolism 27 3.54e-01 4.15e-01 0.2130 0.173000 0.086400 0.089300 1.21e-01 4.37e-01 4.22e-01
Negative regulation of the PI3K/AKT network 87 1.01e-03 2.79e-03 0.2120 0.139000 -0.010900 -0.160000 2.47e-02 8.60e-01 9.88e-03
RNA Polymerase I Promoter Escape 44 3.59e-03 8.21e-03 0.2120 0.163000 -0.078000 -0.112000 6.14e-02 3.71e-01 2.00e-01
Nervous system development 472 2.22e-19 5.81e-18 0.2120 0.114000 -0.041500 -0.174000 2.22e-05 1.23e-01 9.51e-11
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.53e-01 2.06e-01 0.2120 0.085600 0.000619 -0.194000 3.74e-01 9.95e-01 4.42e-02
ECM proteoglycans 35 1.86e-01 2.40e-01 0.2120 0.115000 0.037800 -0.173000 2.37e-01 6.99e-01 7.59e-02
CRMPs in Sema3A signaling 14 4.70e-01 5.23e-01 0.2110 -0.016100 0.070200 -0.199000 9.17e-01 6.49e-01 1.98e-01
Meiotic synapsis 45 4.81e-03 1.06e-02 0.2110 0.171000 -0.058400 -0.108000 4.66e-02 4.98e-01 2.09e-01
RNA polymerase II transcribes snRNA genes 72 1.51e-02 2.86e-02 0.2110 0.110000 0.036100 0.176000 1.06e-01 5.96e-01 9.89e-03
Regulation of TP53 Activity 151 5.86e-04 1.71e-03 0.2100 -0.098500 -0.182000 0.036900 3.67e-02 1.14e-04 4.34e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 7.74e-02 1.16e-01 0.2100 0.105000 -0.015600 -0.181000 2.40e-01 8.61e-01 4.21e-02
HIV Transcription Elongation 42 7.74e-02 1.16e-01 0.2100 0.105000 -0.015600 -0.181000 2.40e-01 8.61e-01 4.21e-02
Tat-mediated elongation of the HIV-1 transcript 42 7.74e-02 1.16e-01 0.2100 0.105000 -0.015600 -0.181000 2.40e-01 8.61e-01 4.21e-02
CD28 dependent Vav1 pathway 12 7.42e-01 7.72e-01 0.2100 0.169000 0.099200 0.074000 3.09e-01 5.52e-01 6.57e-01
Class I peroxisomal membrane protein import 20 5.84e-01 6.28e-01 0.2100 -0.122000 -0.157000 0.066100 3.44e-01 2.24e-01 6.09e-01
Other interleukin signaling 18 4.95e-01 5.47e-01 0.2090 0.051800 0.049700 -0.196000 7.03e-01 7.15e-01 1.49e-01
Phospholipid metabolism 184 2.43e-04 8.14e-04 0.2090 0.181000 0.099600 -0.032400 2.30e-05 1.99e-02 4.48e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.32e-02 2.55e-02 0.2090 -0.029700 -0.185000 -0.093400 6.82e-01 1.07e-02 1.96e-01
Circadian Clock 67 2.69e-03 6.41e-03 0.2080 0.173000 -0.008440 -0.116000 1.46e-02 9.05e-01 1.00e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 3.42e-02 5.84e-02 0.2080 0.201000 0.052000 0.016900 1.23e-02 5.17e-01 8.33e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 2.98e-01 3.58e-01 0.2080 -0.024100 -0.206000 0.010600 8.64e-01 1.41e-01 9.40e-01
Interconversion of nucleotide di- and triphosphates 27 1.33e-02 2.55e-02 0.2060 0.097000 -0.181000 0.025000 3.83e-01 1.04e-01 8.22e-01
Cellular responses to external stimuli 505 9.85e-28 3.83e-26 0.2060 0.146000 -0.068600 -0.128000 1.77e-08 8.32e-03 8.84e-07
G alpha (12/13) signalling events 68 6.06e-02 9.44e-02 0.2060 0.158000 0.086400 -0.099900 2.43e-02 2.18e-01 1.54e-01
Cellular responses to stress 499 1.33e-27 5.04e-26 0.2060 0.142000 -0.073900 -0.129000 5.19e-08 4.71e-03 7.84e-07
RNA Polymerase I Promoter Clearance 63 1.50e-03 3.87e-03 0.2060 0.067900 -0.140000 -0.135000 3.51e-01 5.51e-02 6.37e-02
RNA Polymerase I Transcription 63 1.50e-03 3.87e-03 0.2060 0.067900 -0.140000 -0.135000 3.51e-01 5.51e-02 6.37e-02
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 5.52e-01 5.99e-01 0.2060 0.163000 -0.002170 -0.126000 3.50e-01 9.90e-01 4.70e-01
Activation of BH3-only proteins 29 5.40e-02 8.62e-02 0.2060 0.117000 -0.101000 -0.136000 2.75e-01 3.48e-01 2.06e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 3.03e-02 5.23e-02 0.2050 0.082700 -0.176000 0.065100 4.83e-01 1.35e-01 5.81e-01
Negative regulation of MAPK pathway 42 7.54e-02 1.14e-01 0.2050 0.192000 0.042600 -0.059100 3.13e-02 6.33e-01 5.08e-01
Signaling by ERBB2 44 2.54e-02 4.49e-02 0.2050 0.167000 -0.016100 -0.119000 5.59e-02 8.53e-01 1.74e-01
Adherens junctions interactions 16 4.46e-01 5.01e-01 0.2040 0.050800 0.175000 -0.092100 7.25e-01 2.25e-01 5.24e-01
Peroxisomal protein import 57 9.10e-02 1.34e-01 0.2040 0.182000 0.085100 0.036700 1.74e-02 2.67e-01 6.32e-01
Transcriptional Regulation by MECP2 47 7.84e-02 1.17e-01 0.2040 0.146000 0.029600 -0.140000 8.39e-02 7.26e-01 9.71e-02
Apoptotic cleavage of cellular proteins 34 3.77e-01 4.34e-01 0.2030 0.173000 0.106000 0.008590 8.03e-02 2.84e-01 9.31e-01
DNA Double-Strand Break Repair 135 2.60e-03 6.23e-03 0.2030 -0.102000 -0.141000 0.105000 4.03e-02 4.69e-03 3.50e-02
Formation of the Early Elongation Complex 33 1.99e-01 2.54e-01 0.2030 0.124000 0.019300 -0.160000 2.17e-01 8.47e-01 1.13e-01
Formation of the HIV-1 Early Elongation Complex 33 1.99e-01 2.54e-01 0.2030 0.124000 0.019300 -0.160000 2.17e-01 8.47e-01 1.13e-01
CD209 (DC-SIGN) signaling 20 5.05e-01 5.56e-01 0.2030 0.185000 0.080600 -0.017800 1.51e-01 5.33e-01 8.91e-01
mRNA Splicing - Major Pathway 179 6.51e-09 7.10e-08 0.2030 -0.003840 -0.202000 -0.017700 9.29e-01 3.12e-06 6.83e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 7.05e-01 7.39e-01 0.2030 -0.109000 -0.167000 0.032100 4.63e-01 2.62e-01 8.29e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 3.68e-01 4.26e-01 0.2030 0.111000 -0.032800 0.167000 4.59e-01 8.26e-01 2.64e-01
Aflatoxin activation and detoxification 14 7.84e-01 8.11e-01 0.2020 0.158000 0.124000 0.024500 3.07e-01 4.23e-01 8.74e-01
Cilium Assembly 180 2.91e-04 9.55e-04 0.2020 -0.099100 -0.156000 0.081500 2.18e-02 3.10e-04 5.93e-02
Cellular hexose transport 15 6.58e-01 6.97e-01 0.2020 -0.105000 -0.068400 -0.158000 4.83e-01 6.47e-01 2.88e-01
Signaling by TGFB family members 91 1.47e-05 7.29e-05 0.2010 0.180000 -0.048200 -0.075200 2.93e-03 4.27e-01 2.15e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 3.67e-01 4.25e-01 0.2010 0.013900 -0.062000 0.190000 9.14e-01 6.31e-01 1.41e-01
Developmental Biology 725 4.86e-26 1.74e-24 0.2010 0.136000 -0.011700 -0.147000 4.01e-10 5.92e-01 1.80e-11
Activation of kainate receptors upon glutamate binding 26 2.45e-01 3.05e-01 0.2000 0.180000 0.033600 -0.080500 1.11e-01 7.67e-01 4.77e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 1.21e-02 2.37e-02 0.2000 0.022200 -0.199000 0.006530 8.08e-01 2.95e-02 9.43e-01
Nucleosome assembly 40 1.21e-02 2.37e-02 0.2000 0.022200 -0.199000 0.006530 8.08e-01 2.95e-02 9.43e-01
Miscellaneous transport and binding events 20 9.38e-02 1.37e-01 0.2000 0.146000 -0.106000 -0.084800 2.57e-01 4.10e-01 5.11e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 7.75e-02 1.16e-01 0.2000 0.036200 -0.163000 0.110000 7.54e-01 1.60e-01 3.40e-01
Mitotic Metaphase and Anaphase 224 4.42e-13 8.86e-12 0.2000 0.111000 -0.081200 0.145000 4.23e-03 3.64e-02 1.89e-04
Gene expression (Transcription) 1321 4.01e-25 1.40e-23 0.1990 -0.101000 -0.172000 0.006770 8.58e-10 7.74e-26 6.80e-01
VEGFR2 mediated cell proliferation 18 3.64e-01 4.23e-01 0.1990 0.165000 0.005990 -0.111000 2.25e-01 9.65e-01 4.16e-01
Ub-specific processing proteases 170 1.49e-08 1.49e-07 0.1980 0.182000 -0.007460 0.078500 4.18e-05 8.67e-01 7.74e-02
Mitotic Anaphase 223 6.26e-13 1.24e-11 0.1980 0.116000 -0.077300 0.141000 2.93e-03 4.68e-02 2.81e-04
Vitamin B5 (pantothenate) metabolism 17 7.55e-01 7.85e-01 0.1980 0.142000 0.129000 0.049200 3.12e-01 3.58e-01 7.25e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 2.41e-03 5.81e-03 0.1970 0.047400 -0.185000 0.049400 5.74e-01 2.80e-02 5.58e-01
Insulin receptor signalling cascade 39 1.32e-01 1.84e-01 0.1970 0.163000 0.033300 -0.106000 7.82e-02 7.19e-01 2.50e-01
Orc1 removal from chromatin 69 4.01e-04 1.26e-03 0.1960 0.141000 -0.055600 0.125000 4.36e-02 4.25e-01 7.25e-02
Dopamine Neurotransmitter Release Cycle 19 5.02e-01 5.53e-01 0.1960 -0.040300 -0.160000 -0.105000 7.61e-01 2.26e-01 4.28e-01
Cyclin E associated events during G1/S transition 83 1.55e-04 5.44e-04 0.1960 0.175000 -0.020600 0.084100 5.71e-03 7.45e-01 1.85e-01
Muscle contraction 134 1.74e-02 3.24e-02 0.1960 0.150000 0.119000 -0.042000 2.80e-03 1.76e-02 4.01e-01
Synthesis of bile acids and bile salts 24 4.28e-01 4.82e-01 0.1950 0.143000 0.059500 0.118000 2.25e-01 6.14e-01 3.15e-01
NoRC negatively regulates rRNA expression 59 1.79e-03 4.49e-03 0.1940 0.163000 -0.056100 -0.090400 3.06e-02 4.56e-01 2.30e-01
mRNA Splicing 187 7.15e-09 7.73e-08 0.1940 -0.000579 -0.194000 -0.004390 9.89e-01 4.72e-06 9.18e-01
Peptide hormone metabolism 49 7.78e-03 1.61e-02 0.1930 0.159000 -0.032200 0.106000 5.48e-02 6.97e-01 2.00e-01
FRS-mediated FGFR2 signaling 14 3.64e-01 4.22e-01 0.1930 0.014800 -0.158000 0.110000 9.24e-01 3.05e-01 4.78e-01
Acyl chain remodelling of PE 20 2.73e-01 3.32e-01 0.1930 0.187000 0.013400 0.045400 1.47e-01 9.18e-01 7.25e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 9.90e-02 1.43e-01 0.1930 0.006040 -0.182000 -0.062300 9.54e-01 7.88e-02 5.48e-01
HCMV Late Events 69 3.59e-03 8.21e-03 0.1930 0.169000 -0.012000 -0.092400 1.54e-02 8.63e-01 1.84e-01
Branched-chain amino acid catabolism 21 5.02e-01 5.53e-01 0.1930 -0.056800 -0.066800 0.171000 6.52e-01 5.96e-01 1.74e-01
RNA Polymerase II Transcription Termination 65 9.69e-03 1.94e-02 0.1920 -0.029500 -0.179000 0.064400 6.81e-01 1.28e-02 3.69e-01
RNA Polymerase III Abortive And Retractive Initiation 41 3.09e-01 3.68e-01 0.1920 -0.091800 -0.168000 -0.017100 3.09e-01 6.33e-02 8.49e-01
RNA Polymerase III Transcription 41 3.09e-01 3.68e-01 0.1920 -0.091800 -0.168000 -0.017100 3.09e-01 6.33e-02 8.49e-01
Retrograde transport at the Trans-Golgi-Network 49 1.48e-01 2.02e-01 0.1920 0.176000 0.072600 0.023100 3.30e-02 3.79e-01 7.80e-01
G2/M Checkpoints 138 1.21e-06 7.94e-06 0.1920 0.054000 -0.102000 0.153000 2.74e-01 3.78e-02 1.91e-03
Generic Transcription Pathway 1075 2.62e-17 6.38e-16 0.1910 -0.102000 -0.161000 -0.019300 1.87e-08 4.36e-19 2.86e-01
Homology Directed Repair 110 1.30e-02 2.50e-02 0.1910 -0.089900 -0.137000 0.099100 1.03e-01 1.32e-02 7.24e-02
Transcriptional regulation by RUNX1 184 2.19e-06 1.34e-05 0.1910 0.152000 0.004670 -0.115000 3.60e-04 9.13e-01 6.95e-03
FRS-mediated FGFR4 signaling 12 2.38e-01 2.97e-01 0.1910 0.158000 -0.107000 0.014100 3.44e-01 5.21e-01 9.33e-01
Dual incision in TC-NER 65 1.14e-02 2.24e-02 0.1910 -0.018100 -0.184000 -0.047100 8.00e-01 1.03e-02 5.11e-01
Amino acid transport across the plasma membrane 23 4.48e-01 5.02e-01 0.1900 0.147000 0.047800 -0.111000 2.23e-01 6.92e-01 3.56e-01
Transport of vitamins, nucleosides, and related molecules 33 5.28e-01 5.76e-01 0.1900 0.147000 0.121000 -0.005620 1.45e-01 2.30e-01 9.55e-01
Interferon gamma signaling 83 3.10e-03 7.23e-03 0.1900 -0.144000 0.011400 0.123000 2.32e-02 8.57e-01 5.30e-02
Mitochondrial biogenesis 88 1.67e-03 4.21e-03 0.1890 0.165000 0.000175 -0.092600 7.61e-03 9.98e-01 1.33e-01
Activation of SMO 13 6.46e-01 6.88e-01 0.1890 0.027000 0.084200 -0.167000 8.66e-01 5.99e-01 2.98e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 3.08e-01 3.68e-01 0.1890 -0.016100 -0.160000 0.099500 9.01e-01 2.17e-01 4.41e-01
Mitotic G1 phase and G1/S transition 148 1.88e-07 1.44e-06 0.1890 0.032400 -0.144000 0.118000 4.96e-01 2.55e-03 1.34e-02
Class I MHC mediated antigen processing & presentation 348 1.12e-09 1.31e-08 0.1880 0.172000 0.049200 0.057700 3.58e-08 1.15e-01 6.46e-02
IRF3-mediated induction of type I IFN 12 6.53e-01 6.93e-01 0.1870 -0.034000 -0.173000 -0.062400 8.39e-01 2.98e-01 7.08e-01
SUMOylation of transcription cofactors 44 1.25e-01 1.76e-01 0.1870 0.063800 -0.044100 -0.171000 4.64e-01 6.13e-01 5.04e-02
Transcriptional regulation of pluripotent stem cells 19 3.70e-01 4.27e-01 0.1870 0.183000 0.025300 0.032800 1.68e-01 8.48e-01 8.05e-01
Signaling by Hedgehog 120 2.82e-03 6.64e-03 0.1860 0.177000 0.058500 0.002250 8.13e-04 2.68e-01 9.66e-01
Cell surface interactions at the vascular wall 173 7.86e-11 1.07e-09 0.1860 0.116000 -0.127000 -0.071000 8.64e-03 3.91e-03 1.07e-01
CASP8 activity is inhibited 11 6.88e-01 7.25e-01 0.1860 -0.010700 -0.081700 0.167000 9.51e-01 6.39e-01 3.39e-01
Dimerization of procaspase-8 11 6.88e-01 7.25e-01 0.1860 -0.010700 -0.081700 0.167000 9.51e-01 6.39e-01 3.39e-01
Regulation by c-FLIP 11 6.88e-01 7.25e-01 0.1860 -0.010700 -0.081700 0.167000 9.51e-01 6.39e-01 3.39e-01
SUMOylation 165 1.64e-04 5.72e-04 0.1850 -0.051700 -0.176000 -0.016900 2.52e-01 9.24e-05 7.09e-01
Downstream signaling of activated FGFR3 16 2.25e-01 2.83e-01 0.1840 0.135000 -0.076200 0.099700 3.50e-01 5.98e-01 4.90e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 5.62e-01 6.08e-01 0.1840 0.009810 -0.132000 0.128000 9.55e-01 4.48e-01 4.62e-01
Synthesis of PIPs at the early endosome membrane 16 6.52e-01 6.93e-01 0.1840 -0.010200 0.005210 0.184000 9.44e-01 9.71e-01 2.04e-01
RUNX3 regulates p14-ARF 10 8.33e-01 8.54e-01 0.1840 0.124000 0.076600 -0.112000 4.98e-01 6.75e-01 5.38e-01
Downstream signaling of activated FGFR2 19 2.77e-01 3.36e-01 0.1840 0.015700 -0.145000 0.112000 9.05e-01 2.75e-01 3.97e-01
Phase II - Conjugation of compounds 66 2.29e-01 2.87e-01 0.1840 0.101000 0.122000 0.094100 1.57e-01 8.75e-02 1.86e-01
MET activates PTK2 signaling 15 4.01e-01 4.57e-01 0.1840 0.145000 -0.039700 -0.106000 3.32e-01 7.90e-01 4.77e-01
Unfolded Protein Response (UPR) 86 1.24e-03 3.31e-03 0.1840 0.183000 0.006970 -0.004750 3.28e-03 9.11e-01 9.39e-01
Processing of SMDT1 15 2.63e-01 3.22e-01 0.1830 0.048900 -0.177000 -0.007800 7.43e-01 2.36e-01 9.58e-01
Factors involved in megakaryocyte development and platelet production 115 7.95e-04 2.25e-03 0.1830 0.180000 0.032300 -0.012300 8.52e-04 5.49e-01 8.19e-01
Gene Silencing by RNA 87 1.06e-03 2.90e-03 0.1830 0.001400 -0.179000 -0.038500 9.82e-01 3.96e-03 5.34e-01
Intrinsic Pathway for Apoptosis 52 2.91e-02 5.06e-02 0.1830 0.182000 0.011800 -0.016500 2.35e-02 8.83e-01 8.37e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 4.79e-02 7.75e-02 0.1820 0.092000 -0.071700 -0.140000 2.80e-01 4.00e-01 9.96e-02
RHO GTPases Activate Formins 117 1.51e-04 5.35e-04 0.1820 0.018600 -0.108000 0.145000 7.29e-01 4.27e-02 6.67e-03
Chromatin modifying enzymes 217 1.24e-05 6.34e-05 0.1820 0.047800 -0.049800 -0.168000 2.25e-01 2.06e-01 1.89e-05
Chromatin organization 217 1.24e-05 6.34e-05 0.1820 0.047800 -0.049800 -0.168000 2.25e-01 2.06e-01 1.89e-05
Neuronal System 253 2.58e-04 8.52e-04 0.1820 0.111000 0.108000 -0.095300 2.35e-03 3.21e-03 9.08e-03
Cell Cycle 622 3.12e-22 9.23e-21 0.1810 -0.008890 -0.147000 0.105000 7.05e-01 3.46e-10 7.75e-06
Lysine catabolism 11 8.28e-01 8.50e-01 0.1810 0.087100 0.158000 -0.006360 6.17e-01 3.63e-01 9.71e-01
HCMV Early Events 74 1.11e-03 3.01e-03 0.1810 0.017400 -0.180000 -0.001450 7.96e-01 7.43e-03 9.83e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 5.05e-03 1.09e-02 0.1800 -0.007110 -0.174000 -0.048700 9.14e-01 8.01e-03 4.57e-01
Deubiquitination 241 3.02e-08 2.70e-07 0.1800 0.175000 0.020600 0.038800 2.90e-06 5.81e-01 2.99e-01
Interleukin-37 signaling 19 5.69e-01 6.13e-01 0.1800 0.063000 0.168000 -0.012300 6.34e-01 2.04e-01 9.26e-01
Switching of origins to a post-replicative state 89 2.36e-04 7.92e-04 0.1800 0.105000 -0.065800 0.131000 8.70e-02 2.84e-01 3.30e-02
Fc epsilon receptor (FCERI) signaling 190 7.39e-13 1.42e-11 0.1800 0.133000 -0.113000 0.045000 1.57e-03 7.37e-03 2.85e-01
Protein methylation 15 1.88e-01 2.40e-01 0.1800 0.128000 -0.126000 -0.002150 3.91e-01 3.97e-01 9.88e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 1.44e-01 1.97e-01 0.1800 0.101000 -0.009230 -0.148000 2.47e-01 9.16e-01 8.87e-02
Molecules associated with elastic fibres 22 1.79e-01 2.31e-01 0.1790 0.111000 -0.095000 -0.104000 3.68e-01 4.40e-01 3.98e-01
Synthesis of PIPs at the plasma membrane 52 2.95e-01 3.56e-01 0.1790 0.135000 0.094700 -0.069200 9.26e-02 2.38e-01 3.88e-01
Formation of TC-NER Pre-Incision Complex 53 3.29e-03 7.60e-03 0.1780 0.110000 -0.119000 -0.075000 1.68e-01 1.34e-01 3.45e-01
Lysosphingolipid and LPA receptors 11 6.99e-01 7.33e-01 0.1780 -0.015100 -0.154000 -0.087100 9.31e-01 3.75e-01 6.17e-01
Cyclin A:Cdk2-associated events at S phase entry 85 3.50e-04 1.12e-03 0.1780 0.159000 -0.030500 0.072900 1.13e-02 6.27e-01 2.46e-01
O-linked glycosylation of mucins 47 4.15e-01 4.70e-01 0.1780 0.129000 0.116000 -0.036800 1.26e-01 1.69e-01 6.63e-01
Nicotinamide salvaging 14 5.64e-01 6.09e-01 0.1770 -0.097600 0.043900 0.141000 5.27e-01 7.76e-01 3.59e-01
Transmission across Chemical Synapses 169 7.99e-03 1.64e-02 0.1770 0.139000 0.092400 -0.059000 1.77e-03 3.82e-02 1.86e-01
Signaling by FGFR2 60 1.17e-02 2.30e-02 0.1770 0.103000 -0.075400 -0.123000 1.70e-01 3.13e-01 9.85e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 1.45e-02 2.75e-02 0.1770 -0.044800 -0.159000 0.063900 4.78e-01 1.18e-02 3.11e-01
The phototransduction cascade 25 6.24e-01 6.69e-01 0.1760 -0.092100 -0.150000 0.002400 4.25e-01 1.93e-01 9.83e-01
SUMO E3 ligases SUMOylate target proteins 159 4.72e-04 1.42e-03 0.1760 -0.043700 -0.167000 -0.035200 3.42e-01 2.87e-04 4.44e-01
MAPK1/MAPK3 signaling 234 1.47e-07 1.15e-06 0.1760 0.169000 0.014600 -0.044500 8.07e-06 7.00e-01 2.41e-01
RNA Polymerase II Transcription 1194 3.71e-18 9.36e-17 0.1760 -0.085600 -0.153000 0.001230 6.32e-07 4.51e-19 9.43e-01
Glyoxylate metabolism and glycine degradation 24 3.02e-01 3.61e-01 0.1760 -0.001780 -0.119000 0.129000 9.88e-01 3.12e-01 2.75e-01
Mitotic G2-G2/M phases 180 2.14e-08 2.00e-07 0.1750 0.089900 -0.082000 0.126000 3.75e-02 5.78e-02 3.46e-03
Death Receptor Signalling 131 6.25e-03 1.31e-02 0.1750 0.142000 0.051600 -0.088800 4.98e-03 3.08e-01 7.92e-02
Fatty acid metabolism 151 1.33e-02 2.55e-02 0.1750 0.149000 0.086900 -0.030900 1.56e-03 6.55e-02 5.12e-01
Interleukin receptor SHC signaling 23 6.53e-01 6.93e-01 0.1750 0.100000 0.123000 -0.074000 4.04e-01 3.07e-01 5.39e-01
Cell Cycle, Mitotic 500 3.34e-20 9.11e-19 0.1750 0.019800 -0.139000 0.105000 4.48e-01 1.12e-07 5.41e-05
FRS-mediated FGFR1 signaling 14 6.84e-01 7.23e-01 0.1750 0.143000 0.045500 0.090500 3.54e-01 7.68e-01 5.58e-01
PI3K Cascade 30 2.49e-01 3.09e-01 0.1750 0.056100 -0.079900 -0.146000 5.95e-01 4.49e-01 1.68e-01
Signal Transduction 1870 3.75e-39 2.32e-37 0.1750 0.153000 0.043500 -0.072400 4.52e-28 1.85e-03 2.20e-07
Negative epigenetic regulation of rRNA expression 62 2.82e-03 6.64e-03 0.1750 0.123000 -0.087800 -0.087700 9.43e-02 2.32e-01 2.32e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 4.94e-02 7.96e-02 0.1750 0.059700 -0.086300 -0.140000 4.48e-01 2.72e-01 7.62e-02
DNA Repair 289 4.32e-05 1.77e-04 0.1750 -0.082600 -0.149000 0.039500 1.57e-02 1.37e-05 2.48e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.34e-01 6.77e-01 0.1750 -0.076200 0.079200 0.136000 6.62e-01 6.49e-01 4.36e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 6.82e-01 7.21e-01 0.1740 0.032300 -0.108000 -0.132000 8.53e-01 5.34e-01 4.49e-01
Signaling by BMP 21 3.78e-01 4.36e-01 0.1740 -0.019100 -0.146000 0.091400 8.80e-01 2.45e-01 4.69e-01
WNT ligand biogenesis and trafficking 21 6.71e-01 7.10e-01 0.1740 0.063300 0.134000 0.090600 6.16e-01 2.88e-01 4.72e-01
mRNA 3’-end processing 56 7.88e-02 1.18e-01 0.1730 -0.038500 -0.139000 0.096300 6.19e-01 7.23e-02 2.13e-01
Recruitment of NuMA to mitotic centrosomes 79 8.80e-02 1.30e-01 0.1730 -0.076400 -0.152000 0.031100 2.41e-01 1.95e-02 6.33e-01
Protein-protein interactions at synapses 56 1.64e-01 2.17e-01 0.1730 0.005970 0.002450 -0.173000 9.38e-01 9.75e-01 2.53e-02
FLT3 Signaling 243 4.02e-07 2.91e-06 0.1730 0.163000 0.018800 -0.055600 1.27e-05 6.13e-01 1.36e-01
Regulation of actin dynamics for phagocytic cup formation 123 3.00e-06 1.75e-05 0.1730 0.160000 -0.044200 0.048000 2.20e-03 3.97e-01 3.58e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 2.67e-01 3.26e-01 0.1720 0.138000 -0.012400 -0.103000 2.16e-01 9.11e-01 3.54e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 2.67e-01 3.26e-01 0.1720 0.138000 -0.012400 -0.103000 2.16e-01 9.11e-01 3.54e-01
Formation of RNA Pol II elongation complex 57 5.83e-02 9.16e-02 0.1720 0.150000 0.011500 -0.084300 5.06e-02 8.80e-01 2.71e-01
RNA Polymerase II Transcription Elongation 57 5.83e-02 9.16e-02 0.1720 0.150000 0.011500 -0.084300 5.06e-02 8.80e-01 2.71e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 2.49e-02 4.40e-02 0.1720 -0.064600 -0.115000 0.111000 2.55e-01 4.35e-02 5.07e-02
Signaling by the B Cell Receptor (BCR) 162 1.04e-09 1.22e-08 0.1720 0.087200 -0.141000 0.046300 5.54e-02 1.99e-03 3.09e-01
MAPK family signaling cascades 267 1.09e-08 1.13e-07 0.1710 0.168000 0.009360 -0.032400 2.31e-06 7.92e-01 3.62e-01
G2/M Transition 178 5.96e-08 5.05e-07 0.1710 0.082700 -0.085400 0.123000 5.69e-02 4.93e-02 4.66e-03
Regulation of PLK1 Activity at G2/M Transition 86 4.19e-03 9.41e-03 0.1710 -0.012200 -0.152000 0.077800 8.45e-01 1.50e-02 2.12e-01
RUNX2 regulates bone development 23 3.11e-01 3.70e-01 0.1710 0.013700 0.160000 -0.059600 9.10e-01 1.85e-01 6.21e-01
Metabolism of folate and pterines 16 7.12e-01 7.46e-01 0.1710 0.140000 0.060300 0.076100 3.31e-01 6.76e-01 5.98e-01
DNA Replication Pre-Initiation 82 7.75e-04 2.21e-03 0.1700 0.051000 -0.119000 0.111000 4.25e-01 6.30e-02 8.20e-02
Keratan sulfate/keratin metabolism 27 6.26e-01 6.70e-01 0.1700 0.116000 0.096500 -0.079300 2.97e-01 3.86e-01 4.76e-01
Eicosanoid ligand-binding receptors 13 7.36e-01 7.66e-01 0.1700 -0.051500 -0.160000 -0.022400 7.48e-01 3.16e-01 8.89e-01
ADORA2B mediated anti-inflammatory cytokines production 73 3.62e-02 6.15e-02 0.1700 0.075100 -0.038500 -0.148000 2.68e-01 5.69e-01 2.93e-02
Interleukin-2 family signaling 38 4.79e-01 5.31e-01 0.1700 0.093400 0.137000 -0.035400 3.19e-01 1.43e-01 7.06e-01
Downstream signal transduction 27 2.97e-01 3.57e-01 0.1690 0.163000 0.021500 0.040500 1.42e-01 8.47e-01 7.16e-01
DNA Double Strand Break Response 47 6.37e-02 9.86e-02 0.1690 0.079400 -0.079500 -0.127000 3.46e-01 3.46e-01 1.33e-01
Infectious disease 775 4.62e-33 1.97e-31 0.1690 0.121000 -0.076900 -0.088800 8.94e-09 2.70e-04 2.60e-05
Transcriptional regulation by small RNAs 63 4.92e-03 1.07e-02 0.1680 0.074200 -0.126000 -0.083700 3.09e-01 8.44e-02 2.51e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.21e-01 8.44e-01 0.1680 0.115000 0.031800 -0.118000 5.28e-01 8.62e-01 5.17e-01
RAF/MAP kinase cascade 229 1.07e-06 7.16e-06 0.1670 0.160000 0.013100 -0.048100 3.15e-05 7.32e-01 2.09e-01
Anchoring of the basal body to the plasma membrane 96 4.85e-02 7.83e-02 0.1670 -0.068800 -0.128000 0.081900 2.44e-01 3.03e-02 1.65e-01
SHC-mediated cascade:FGFR1 12 8.49e-01 8.68e-01 0.1660 0.107000 0.070800 0.106000 5.21e-01 6.71e-01 5.25e-01
Metabolism 1756 7.88e-35 3.70e-33 0.1660 0.137000 0.030900 -0.088200 1.16e-21 3.19e-02 8.31e-10
Potential therapeutics for SARS 77 7.15e-03 1.48e-02 0.1660 0.163000 -0.002620 -0.031300 1.34e-02 9.68e-01 6.35e-01
Hedgehog ‘off’ state 92 8.47e-03 1.72e-02 0.1660 0.164000 0.023400 -0.008410 6.52e-03 6.98e-01 8.89e-01
Cargo trafficking to the periciliary membrane 47 4.72e-02 7.63e-02 0.1650 0.048100 -0.092200 0.129000 5.68e-01 2.74e-01 1.27e-01
Centrosome maturation 80 1.03e-01 1.48e-01 0.1650 -0.072400 -0.142000 0.043600 2.63e-01 2.78e-02 5.00e-01
Recruitment of mitotic centrosome proteins and complexes 80 1.03e-01 1.48e-01 0.1650 -0.072400 -0.142000 0.043600 2.63e-01 2.78e-02 5.00e-01
HIV Transcription Initiation 45 4.02e-02 6.74e-02 0.1650 0.140000 -0.030200 0.083300 1.05e-01 7.26e-01 3.34e-01
RNA Polymerase II HIV Promoter Escape 45 4.02e-02 6.74e-02 0.1650 0.140000 -0.030200 0.083300 1.05e-01 7.26e-01 3.34e-01
RNA Polymerase II Promoter Escape 45 4.02e-02 6.74e-02 0.1650 0.140000 -0.030200 0.083300 1.05e-01 7.26e-01 3.34e-01
RNA Polymerase II Transcription Initiation 45 4.02e-02 6.74e-02 0.1650 0.140000 -0.030200 0.083300 1.05e-01 7.26e-01 3.34e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 4.02e-02 6.74e-02 0.1650 0.140000 -0.030200 0.083300 1.05e-01 7.26e-01 3.34e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 4.02e-02 6.74e-02 0.1650 0.140000 -0.030200 0.083300 1.05e-01 7.26e-01 3.34e-01
Signaling by WNT in cancer 30 4.81e-01 5.33e-01 0.1650 0.082200 0.028300 -0.140000 4.36e-01 7.89e-01 1.85e-01
Downstream signaling of activated FGFR4 17 2.15e-01 2.72e-01 0.1640 0.117000 -0.107000 0.045300 4.05e-01 4.46e-01 7.47e-01
Metal ion SLC transporters 21 7.74e-01 8.03e-01 0.1630 0.132000 0.094700 0.015600 2.94e-01 4.53e-01 9.01e-01
Fatty acyl-CoA biosynthesis 33 3.21e-01 3.80e-01 0.1630 0.142000 0.032300 0.074500 1.59e-01 7.48e-01 4.59e-01
Neddylation 218 7.84e-07 5.53e-06 0.1630 0.162000 0.007030 0.002100 3.56e-05 8.58e-01 9.57e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 7.19e-01 7.51e-01 0.1630 -0.085400 0.057800 0.126000 6.40e-01 7.51e-01 4.91e-01
Regulation of MECP2 expression and activity 28 4.31e-01 4.85e-01 0.1630 0.135000 0.027000 -0.085900 2.15e-01 8.04e-01 4.31e-01
TNFR2 non-canonical NF-kB pathway 95 4.07e-04 1.27e-03 0.1610 0.158000 -0.030700 0.015600 7.91e-03 6.06e-01 7.93e-01
HCMV Infection 96 4.74e-04 1.42e-03 0.1610 0.150000 -0.038800 -0.042400 1.09e-02 5.12e-01 4.73e-01
Cholesterol biosynthesis 24 5.81e-01 6.25e-01 0.1610 0.092000 0.035300 0.127000 4.35e-01 7.65e-01 2.81e-01
TP53 Regulates Transcription of Cell Death Genes 42 1.11e-01 1.59e-01 0.1610 0.160000 0.005530 0.013300 7.29e-02 9.51e-01 8.81e-01
PECAM1 interactions 12 7.89e-01 8.16e-01 0.1600 -0.007720 0.023100 -0.159000 9.63e-01 8.90e-01 3.42e-01
MECP2 regulates neuronal receptors and channels 13 5.57e-01 6.03e-01 0.1600 0.113000 -0.056600 -0.097900 4.81e-01 7.24e-01 5.41e-01
SHC-mediated cascade:FGFR4 10 4.69e-01 5.22e-01 0.1600 0.117000 -0.107000 0.017500 5.21e-01 5.58e-01 9.24e-01
Phase I - Functionalization of compounds 61 1.80e-01 2.33e-01 0.1600 0.099000 0.029200 -0.122000 1.81e-01 6.93e-01 1.00e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 5.29e-01 5.76e-01 0.1600 0.142000 0.036100 -0.062400 2.27e-01 7.59e-01 5.97e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 1.52e-01 2.05e-01 0.1590 0.073200 -0.082400 -0.115000 4.41e-01 3.86e-01 2.26e-01
Class B/2 (Secretin family receptors) 56 2.17e-01 2.73e-01 0.1590 0.020200 0.028500 -0.155000 7.94e-01 7.12e-01 4.49e-02
FOXO-mediated transcription 58 4.24e-02 7.04e-02 0.1590 0.147000 -0.009100 -0.058700 5.24e-02 9.05e-01 4.39e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.91e-01 3.51e-01 0.1580 -0.049100 -0.102000 -0.110000 5.07e-01 1.68e-01 1.36e-01
Epigenetic regulation of gene expression 100 2.27e-03 5.50e-03 0.1580 0.024200 -0.139000 -0.070900 6.76e-01 1.66e-02 2.20e-01
NCAM signaling for neurite out-growth 43 5.17e-01 5.66e-01 0.1560 -0.087700 -0.128000 0.019700 3.20e-01 1.47e-01 8.23e-01
IRS-related events triggered by IGF1R 35 1.45e-01 1.97e-01 0.1560 0.082100 -0.085500 -0.102000 4.00e-01 3.81e-01 2.98e-01
Signaling by NTRK2 (TRKB) 20 3.39e-01 4.00e-01 0.1550 0.148000 -0.023400 0.037000 2.50e-01 8.56e-01 7.75e-01
Post-translational protein modification 1187 6.19e-25 2.11e-23 0.1540 0.152000 0.028200 -0.004590 1.37e-18 1.01e-01 7.90e-01
Zinc transporters 14 8.17e-01 8.40e-01 0.1540 0.130000 0.059100 0.055700 3.98e-01 7.02e-01 7.18e-01
Nuclear Envelope (NE) Reassembly 69 1.36e-03 3.56e-03 0.1540 0.116000 -0.091600 0.041800 9.60e-02 1.88e-01 5.48e-01
Leishmania infection 245 8.55e-07 5.94e-06 0.1540 0.149000 0.000828 -0.038600 6.19e-05 9.82e-01 2.98e-01
Protein localization 157 7.82e-06 4.18e-05 0.1530 0.117000 -0.063400 -0.076400 1.14e-02 1.70e-01 9.87e-02
RUNX2 regulates osteoblast differentiation 18 3.69e-01 4.27e-01 0.1530 -0.066900 0.092600 -0.102000 6.23e-01 4.97e-01 4.53e-01
G alpha (q) signalling events 130 1.34e-02 2.57e-02 0.1520 0.097700 0.011500 -0.116000 5.43e-02 8.21e-01 2.19e-02
Disorders of transmembrane transporters 145 5.35e-04 1.57e-03 0.1520 0.152000 0.009650 -0.004890 1.59e-03 8.41e-01 9.19e-01
CD28 co-stimulation 33 5.96e-01 6.39e-01 0.1520 -0.050600 -0.063800 -0.129000 6.15e-01 5.26e-01 2.01e-01
IGF1R signaling cascade 36 1.64e-01 2.17e-01 0.1520 0.094000 -0.065000 -0.100000 3.29e-01 5.00e-01 2.98e-01
M Phase 359 5.59e-14 1.17e-12 0.1520 0.089700 -0.079500 0.093200 3.51e-03 9.71e-03 2.43e-03
FCGR3A-mediated phagocytosis 121 2.18e-05 9.90e-05 0.1510 0.134000 -0.060700 0.034500 1.08e-02 2.48e-01 5.12e-01
Leishmania phagocytosis 121 2.18e-05 9.90e-05 0.1510 0.134000 -0.060700 0.034500 1.08e-02 2.48e-01 5.12e-01
Parasite infection 121 2.18e-05 9.90e-05 0.1510 0.134000 -0.060700 0.034500 1.08e-02 2.48e-01 5.12e-01
Signaling by FGFR2 in disease 32 1.28e-01 1.79e-01 0.1510 0.042500 -0.143000 -0.022800 6.77e-01 1.61e-01 8.23e-01
Nonhomologous End-Joining (NHEJ) 42 5.96e-02 9.35e-02 0.1510 0.085300 -0.078700 0.096700 3.39e-01 3.78e-01 2.78e-01
AURKA Activation by TPX2 71 7.36e-02 1.11e-01 0.1510 -0.030200 -0.129000 0.072500 6.60e-01 6.02e-02 2.91e-01
Disease 1343 4.25e-35 2.14e-33 0.1510 0.127000 -0.022400 -0.078400 7.33e-15 1.68e-01 1.43e-06
Inactivation, recovery and regulation of the phototransduction cascade 24 6.50e-01 6.92e-01 0.1500 -0.059400 -0.133000 0.034200 6.15e-01 2.60e-01 7.72e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 6.32e-01 6.75e-01 0.1490 0.133000 -0.050500 -0.044400 4.65e-01 7.82e-01 8.08e-01
Nucleotide Excision Repair 110 5.56e-03 1.18e-02 0.1490 -0.009150 -0.147000 -0.022200 8.68e-01 7.54e-03 6.88e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 4.35e-01 4.89e-01 0.1490 -0.031800 -0.072400 0.126000 7.41e-01 4.52e-01 1.89e-01
Diseases of mitotic cell cycle 36 4.35e-01 4.89e-01 0.1490 -0.031800 -0.072400 0.126000 7.41e-01 4.52e-01 1.89e-01
Interleukin-20 family signaling 17 8.78e-01 8.90e-01 0.1490 0.111000 0.099500 0.002210 4.28e-01 4.78e-01 9.87e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 6.80e-01 7.19e-01 0.1480 0.123000 0.058400 0.057400 2.86e-01 6.13e-01 6.19e-01
Loss of Nlp from mitotic centrosomes 68 1.60e-01 2.13e-01 0.1480 -0.048900 -0.127000 0.057200 4.86e-01 6.92e-02 4.15e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 1.60e-01 2.13e-01 0.1480 -0.048900 -0.127000 0.057200 4.86e-01 6.92e-02 4.15e-01
DNA Damage Recognition in GG-NER 38 3.84e-01 4.40e-01 0.1480 -0.010500 -0.112000 -0.096200 9.10e-01 2.33e-01 3.05e-01
Activation of NMDA receptors and postsynaptic events 58 8.34e-02 1.24e-01 0.1470 0.103000 -0.033000 -0.099100 1.74e-01 6.64e-01 1.92e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 4.65e-01 5.19e-01 0.1460 0.090900 -0.040800 -0.107000 4.50e-01 7.35e-01 3.73e-01
Downstream signaling of activated FGFR1 20 6.30e-01 6.74e-01 0.1460 0.094300 0.011800 0.111000 4.65e-01 9.27e-01 3.90e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 1.07e-04 4.01e-04 0.1460 0.145000 -0.016000 0.011000 2.44e-03 7.38e-01 8.18e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 7.99e-01 8.25e-01 0.1460 -0.030100 -0.075800 -0.121000 8.25e-01 5.78e-01 3.76e-01
Metabolism of nucleotides 86 1.84e-03 4.59e-03 0.1450 0.109000 -0.079000 -0.055000 8.17e-02 2.05e-01 3.78e-01
Ion homeostasis 40 4.34e-01 4.88e-01 0.1450 0.016400 0.036300 -0.139000 8.58e-01 6.91e-01 1.28e-01
G alpha (s) signalling events 140 1.08e-01 1.54e-01 0.1440 0.068500 0.085200 0.093500 1.62e-01 8.19e-02 5.61e-02
TICAM1-dependent activation of IRF3/IRF7 12 8.72e-01 8.85e-01 0.1430 0.074900 0.038000 -0.116000 6.53e-01 8.20e-01 4.87e-01
Cell-cell junction organization 36 4.11e-01 4.66e-01 0.1430 0.042900 -0.049000 -0.127000 6.56e-01 6.11e-01 1.87e-01
Anti-inflammatory response favouring Leishmania parasite infection 169 2.07e-04 7.07e-04 0.1430 0.001800 -0.141000 -0.022500 9.68e-01 1.57e-03 6.13e-01
Leishmania parasite growth and survival 169 2.07e-04 7.07e-04 0.1430 0.001800 -0.141000 -0.022500 9.68e-01 1.57e-03 6.13e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 8.15e-01 8.39e-01 0.1430 -0.077000 -0.051200 0.109000 5.83e-01 7.15e-01 4.38e-01
Metabolism of proteins 1709 9.51e-54 4.32e-51 0.1430 0.130000 -0.045600 -0.035600 3.45e-19 1.75e-03 1.45e-02
SLC-mediated transmembrane transport 179 4.21e-02 6.99e-02 0.1410 0.103000 0.071300 -0.064600 1.72e-02 9.98e-02 1.36e-01
HIV Infection 224 7.64e-08 6.27e-07 0.1400 0.130000 -0.043200 0.029400 7.72e-04 2.66e-01 4.49e-01
Signaling by PDGF 44 2.24e-01 2.81e-01 0.1390 0.138000 0.011900 0.014200 1.13e-01 8.91e-01 8.70e-01
Mitotic Prophase 98 4.42e-04 1.35e-03 0.1390 0.118000 -0.072900 0.015000 4.43e-02 2.12e-01 7.98e-01
Post NMDA receptor activation events 48 1.72e-01 2.25e-01 0.1390 0.097900 -0.032500 -0.092900 2.41e-01 6.97e-01 2.65e-01
Signaling by FGFR in disease 50 1.59e-01 2.13e-01 0.1380 0.135000 0.006780 0.028700 9.81e-02 9.34e-01 7.26e-01
Synthesis of PIPs at the Golgi membrane 16 8.29e-01 8.50e-01 0.1380 0.050100 0.126000 0.024200 7.28e-01 3.83e-01 8.67e-01
Synthesis of substrates in N-glycan biosythesis 58 3.31e-01 3.91e-01 0.1370 0.128000 0.047800 -0.001540 9.10e-02 5.29e-01 9.84e-01
Interleukin-35 Signalling 12 7.91e-01 8.17e-01 0.1360 -0.022900 -0.128000 0.041000 8.91e-01 4.42e-01 8.06e-01
Nucleotide-like (purinergic) receptors 12 5.34e-01 5.81e-01 0.1360 0.091300 -0.096400 0.029900 5.84e-01 5.63e-01 8.58e-01
Downstream TCR signaling 100 4.83e-04 1.44e-03 0.1350 0.077100 -0.110000 0.017100 1.83e-01 5.73e-02 7.67e-01
Sema3A PAK dependent Axon repulsion 16 8.70e-01 8.84e-01 0.1350 0.076600 0.076600 -0.080800 5.96e-01 5.96e-01 5.76e-01
Glutamate Neurotransmitter Release Cycle 20 7.23e-01 7.55e-01 0.1350 -0.041700 -0.122000 0.040400 7.47e-01 3.46e-01 7.55e-01
CTLA4 inhibitory signaling 21 7.24e-01 7.55e-01 0.1350 -0.013900 -0.100000 -0.088600 9.12e-01 4.26e-01 4.82e-01
RNA Polymerase II Pre-transcription Events 78 2.24e-02 4.04e-02 0.1340 0.130000 -0.017000 0.028500 4.69e-02 7.95e-01 6.64e-01
G alpha (i) signalling events 240 2.53e-04 8.39e-04 0.1330 0.111000 0.002420 -0.072600 2.98e-03 9.48e-01 5.29e-02
Signaling by FGFR 69 1.51e-01 2.05e-01 0.1330 0.091200 -0.009530 -0.095900 1.90e-01 8.91e-01 1.69e-01
Meiotic recombination 38 1.60e-01 2.14e-01 0.1310 0.121000 -0.042400 -0.027700 1.96e-01 6.51e-01 7.67e-01
Host Interactions of HIV factors 129 7.79e-05 3.00e-04 0.1310 0.085100 -0.099200 0.000162 9.50e-02 5.17e-02 9.97e-01
O-linked glycosylation 82 1.71e-01 2.25e-01 0.1310 -0.063800 -0.011200 -0.114000 3.18e-01 8.61e-01 7.55e-02
Regulation of PTEN mRNA translation 13 7.71e-01 7.99e-01 0.1310 -0.057500 0.058000 0.102000 7.20e-01 7.17e-01 5.24e-01
IRS-mediated signalling 34 2.68e-01 3.27e-01 0.1300 0.064600 -0.083800 -0.076100 5.14e-01 3.98e-01 4.42e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 9.40e-01 9.46e-01 0.1300 0.080900 0.100000 0.019400 6.14e-01 5.33e-01 9.03e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 6.90e-01 7.26e-01 0.1300 0.031000 -0.091900 0.086100 8.47e-01 5.66e-01 5.91e-01
Transcriptional activation of mitochondrial biogenesis 51 1.82e-01 2.34e-01 0.1290 0.097400 -0.030300 -0.079600 2.29e-01 7.08e-01 3.25e-01
Kinesins 39 2.74e-01 3.33e-01 0.1290 0.002780 -0.129000 -0.009100 9.76e-01 1.63e-01 9.22e-01
HIV Life Cycle 144 1.94e-04 6.66e-04 0.1280 0.045100 -0.109000 0.051500 3.50e-01 2.44e-02 2.86e-01
Cytochrome P450 - arranged by substrate type 33 8.01e-01 8.26e-01 0.1260 0.098600 0.077300 -0.010600 3.27e-01 4.42e-01 9.16e-01
Glucagon-type ligand receptors 20 6.36e-01 6.78e-01 0.1260 0.043200 -0.076100 -0.090000 7.38e-01 5.56e-01 4.86e-01
PI Metabolism 79 4.77e-01 5.30e-01 0.1250 0.098900 0.073900 -0.021700 1.29e-01 2.56e-01 7.39e-01
Glucose metabolism 83 3.59e-01 4.19e-01 0.1230 0.097700 0.052100 -0.053700 1.24e-01 4.12e-01 3.98e-01
Nicotinate metabolism 25 4.68e-01 5.22e-01 0.1220 -0.012400 0.121000 -0.010000 9.15e-01 2.94e-01 9.31e-01
Antigen processing: Ubiquitination & Proteasome degradation 287 3.60e-06 2.06e-05 0.1210 0.112000 -0.016500 0.044400 1.15e-03 6.31e-01 1.96e-01
Peptide ligand-binding receptors 91 1.01e-01 1.46e-01 0.1210 0.108000 0.004680 -0.053800 7.57e-02 9.39e-01 3.75e-01
Acyl chain remodelling of PS 14 7.62e-01 7.92e-01 0.1200 0.089300 -0.014000 0.079300 5.63e-01 9.28e-01 6.07e-01
GABA synthesis, release, reuptake and degradation 13 9.12e-01 9.21e-01 0.1190 -0.030600 -0.092100 -0.069400 8.48e-01 5.65e-01 6.65e-01
Negative regulators of DDX58/IFIH1 signaling 34 4.99e-01 5.51e-01 0.1190 -0.014100 -0.106000 0.052200 8.87e-01 2.86e-01 5.99e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 3.78e-01 4.35e-01 0.1150 0.057700 0.024300 -0.096500 3.75e-01 7.09e-01 1.38e-01
Metabolic disorders of biological oxidation enzymes 23 8.65e-01 8.83e-01 0.1140 0.098200 0.052900 -0.024100 4.15e-01 6.61e-01 8.42e-01
TCR signaling 121 1.37e-03 3.59e-03 0.1140 0.077600 -0.082800 0.011100 1.41e-01 1.16e-01 8.33e-01
SLC transporter disorders 75 1.51e-01 2.05e-01 0.1140 -0.004470 -0.113000 -0.008710 9.47e-01 8.93e-02 8.96e-01
Ion transport by P-type ATPases 42 7.16e-01 7.49e-01 0.1120 0.061100 0.054800 -0.076500 4.93e-01 5.39e-01 3.91e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 4.51e-01 5.04e-01 0.1120 0.096800 -0.052200 -0.021200 4.12e-01 6.58e-01 8.57e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 1.81e-01 2.33e-01 0.1110 0.063100 -0.089200 -0.019700 4.74e-01 3.12e-01 8.23e-01
Keratan sulfate biosynthesis 22 8.51e-01 8.70e-01 0.1110 -0.016400 -0.014900 -0.108000 8.94e-01 9.03e-01 3.78e-01
VEGFR2 mediated vascular permeability 26 8.58e-01 8.77e-01 0.1110 0.081100 0.052600 -0.053800 4.74e-01 6.43e-01 6.35e-01
Ca2+ pathway 57 2.72e-01 3.32e-01 0.1100 0.109000 0.000283 -0.014800 1.54e-01 9.97e-01 8.46e-01
Sulfur amino acid metabolism 22 8.34e-01 8.54e-01 0.1090 0.038200 -0.006670 -0.102000 7.56e-01 9.57e-01 4.07e-01
Organelle biogenesis and maintenance 268 1.17e-03 3.15e-03 0.1090 -0.012300 -0.105000 0.024300 7.28e-01 3.08e-03 4.94e-01
Biological oxidations 132 3.21e-01 3.81e-01 0.1080 0.089700 0.055300 -0.025400 7.52e-02 2.73e-01 6.15e-01
PKMTs methylate histone lysines 44 8.08e-01 8.33e-01 0.1080 -0.072600 -0.066300 -0.045400 4.05e-01 4.47e-01 6.02e-01
Late Phase of HIV Life Cycle 131 3.04e-03 7.11e-03 0.1080 0.061900 -0.075800 0.045500 2.21e-01 1.34e-01 3.69e-01
Cytokine Signaling in Immune system 732 1.39e-08 1.41e-07 0.1080 0.107000 0.013700 0.004950 8.59e-07 5.27e-01 8.20e-01
PI-3K cascade:FGFR1 12 8.68e-01 8.83e-01 0.1080 0.096200 0.004460 0.048100 5.64e-01 9.79e-01 7.73e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 6.95e-01 7.31e-01 0.1070 0.060100 0.086900 -0.018400 4.33e-01 2.56e-01 8.10e-01
Signaling by GPCR 530 1.65e-03 4.19e-03 0.1070 0.083300 0.045200 -0.049800 1.04e-03 7.48e-02 4.97e-02
Meiosis 68 8.56e-02 1.27e-01 0.1070 0.036200 -0.101000 0.004440 6.05e-01 1.52e-01 9.50e-01
Signaling by KIT in disease 20 8.68e-01 8.83e-01 0.1060 -0.040100 -0.090600 0.038400 7.56e-01 4.83e-01 7.67e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 8.68e-01 8.83e-01 0.1060 -0.040100 -0.090600 0.038400 7.56e-01 4.83e-01 7.67e-01
Visual phototransduction 58 5.65e-01 6.10e-01 0.1060 0.032600 0.000644 -0.101000 6.68e-01 9.93e-01 1.84e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 4.72e-01 5.23e-01 0.1060 0.083000 -0.063500 0.017400 4.91e-01 5.98e-01 8.85e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 3.34e-01 3.93e-01 0.1060 0.093500 0.018500 0.045500 1.67e-01 7.85e-01 5.02e-01
mRNA Capping 29 4.47e-01 5.01e-01 0.1050 0.088700 -0.047100 -0.031300 4.09e-01 6.61e-01 7.70e-01
Regulation of TNFR1 signaling 34 8.74e-01 8.87e-01 0.1040 -0.060200 -0.068400 -0.049800 5.44e-01 4.90e-01 6.15e-01
Diseases of glycosylation 107 2.39e-01 2.97e-01 0.1040 -0.021100 0.011900 -0.101000 7.06e-01 8.31e-01 7.14e-02
Diseases of metabolism 186 1.19e-01 1.67e-01 0.1020 0.026300 0.028700 -0.094300 5.36e-01 5.00e-01 2.66e-02
Signaling by NTRK3 (TRKC) 16 7.77e-01 8.04e-01 0.1010 0.072000 -0.041400 -0.058000 6.18e-01 7.74e-01 6.88e-01
Cyclin D associated events in G1 47 3.58e-01 4.19e-01 0.1000 0.066000 -0.032100 0.068600 4.34e-01 7.03e-01 4.16e-01
G1 Phase 47 3.58e-01 4.19e-01 0.1000 0.066000 -0.032100 0.068600 4.34e-01 7.03e-01 4.16e-01
Cytosolic sensors of pathogen-associated DNA 62 4.71e-01 5.23e-01 0.0990 0.035500 -0.033700 -0.086000 6.29e-01 6.46e-01 2.42e-01
Transcription of the HIV genome 67 1.18e-01 1.67e-01 0.0983 0.083400 -0.045100 0.026200 2.38e-01 5.23e-01 7.11e-01
GPCR downstream signalling 487 3.87e-03 8.78e-03 0.0976 0.081900 0.033100 -0.041600 1.97e-03 2.12e-01 1.16e-01
Glycolysis 66 3.51e-01 4.11e-01 0.0967 0.093400 0.001620 -0.025000 1.89e-01 9.82e-01 7.25e-01
STING mediated induction of host immune responses 15 8.38e-01 8.58e-01 0.0919 0.088600 -0.010200 0.022200 5.52e-01 9.45e-01 8.82e-01
Transcriptional Regulation by TP53 350 1.23e-05 6.31e-05 0.0896 0.041100 -0.079600 0.002150 1.87e-01 1.05e-02 9.45e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 9.41e-01 9.46e-01 0.0884 -0.029100 -0.031900 0.077100 8.35e-01 8.20e-01 5.82e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 9.41e-01 9.46e-01 0.0884 -0.029100 -0.031900 0.077100 8.35e-01 8.20e-01 5.82e-01
Class A/1 (Rhodopsin-like receptors) 160 5.45e-02 8.68e-02 0.0884 0.055400 -0.036900 -0.058100 2.26e-01 4.21e-01 2.05e-01
Reproduction 80 1.55e-01 2.09e-01 0.0879 0.043300 -0.072000 -0.025800 5.03e-01 2.65e-01 6.90e-01
IL-6-type cytokine receptor ligand interactions 12 9.53e-01 9.56e-01 0.0877 0.038800 -0.010100 -0.078000 8.16e-01 9.52e-01 6.40e-01
Netrin-1 signaling 40 4.16e-01 4.71e-01 0.0871 0.042200 -0.075700 0.008080 6.44e-01 4.07e-01 9.30e-01
TNFR1-induced NFkappaB signaling pathway 25 9.11e-01 9.20e-01 0.0870 -0.037300 -0.077600 0.012700 7.47e-01 5.02e-01 9.12e-01
Methylation 12 9.51e-01 9.55e-01 0.0858 -0.022700 -0.082000 0.011300 8.92e-01 6.23e-01 9.46e-01
Regulation of RUNX1 Expression and Activity 18 9.41e-01 9.46e-01 0.0847 -0.072900 -0.029000 -0.031900 5.92e-01 8.31e-01 8.15e-01
Signaling by Retinoic Acid 31 8.02e-01 8.27e-01 0.0781 0.029100 -0.043100 -0.058200 7.79e-01 6.78e-01 5.75e-01
Cardiac conduction 85 5.15e-01 5.65e-01 0.0776 0.013000 0.076400 0.003860 8.35e-01 2.23e-01 9.51e-01
Association of TriC/CCT with target proteins during biosynthesis 37 6.96e-01 7.32e-01 0.0772 0.046900 -0.037800 -0.048200 6.21e-01 6.90e-01 6.12e-01
Adaptive Immune System 755 5.39e-08 4.64e-07 0.0764 0.070700 -0.028800 -0.001370 9.45e-04 1.79e-01 9.49e-01
Receptor-type tyrosine-protein phosphatases 12 9.89e-01 9.89e-01 0.0757 0.057000 0.049700 0.001530 7.32e-01 7.66e-01 9.93e-01
GPCR ligand binding 226 1.68e-01 2.21e-01 0.0752 0.034000 -0.014900 -0.065400 3.78e-01 6.99e-01 9.01e-02
Interaction between L1 and Ankyrins 21 8.77e-01 8.90e-01 0.0730 0.006030 -0.059000 0.042700 9.62e-01 6.40e-01 7.35e-01
Ovarian tumor domain proteases 37 7.64e-01 7.93e-01 0.0721 0.070700 -0.001720 0.014300 4.57e-01 9.86e-01 8.80e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 7.29e-01 7.60e-01 0.0713 0.065900 0.014900 0.023000 3.66e-01 8.38e-01 7.52e-01
Neurotransmitter release cycle 37 8.65e-01 8.83e-01 0.0696 0.022800 -0.008960 0.065100 8.11e-01 9.25e-01 4.93e-01
TRP channels 17 9.07e-01 9.16e-01 0.0684 -0.065400 0.013100 0.015100 6.40e-01 9.26e-01 9.14e-01
Transcriptional Regulation by VENTX 38 9.21e-01 9.29e-01 0.0678 -0.058800 -0.026000 0.021500 5.30e-01 7.82e-01 8.18e-01
Glutathione synthesis and recycling 10 9.75e-01 9.78e-01 0.0624 -0.001390 0.047900 -0.040000 9.94e-01 7.93e-01 8.27e-01
Metabolism of vitamins and cofactors 155 7.17e-01 7.49e-01 0.0623 0.037600 0.040600 -0.028700 4.20e-01 3.83e-01 5.37e-01
Diseases associated with N-glycosylation of proteins 17 8.99e-01 9.10e-01 0.0617 0.054600 -0.027100 0.009370 6.96e-01 8.47e-01 9.47e-01
Xenobiotics 11 9.87e-01 9.88e-01 0.0580 -0.007920 -0.049200 -0.029700 9.64e-01 7.77e-01 8.65e-01
DAP12 signaling 28 8.67e-01 8.83e-01 0.0527 0.041800 -0.028100 0.015600 7.02e-01 7.97e-01 8.86e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 9.83e-01 9.85e-01 0.0460 0.026400 0.036100 -0.011000 7.84e-01 7.08e-01 9.09e-01
TNF signaling 43 9.00e-01 9.10e-01 0.0453 0.029600 -0.020800 -0.027300 7.37e-01 8.14e-01 7.56e-01
Metabolism of water-soluble vitamins and cofactors 109 9.00e-01 9.10e-01 0.0281 -0.027800 0.003360 -0.002410 6.16e-01 9.52e-01 9.65e-01
Synthesis of PA 32 9.91e-01 9.91e-01 0.0248 0.018900 -0.001940 0.016000 8.54e-01 9.85e-01 8.75e-01


Detailed Gene set reports


IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)
metric value
setSize 10
pMANOVA 2.4e-06
p.adjustMANOVA 1.46e-05
s.dist 1.27
s.t0_v_pod 0.899
s.pod_crp 0.826
s.t0_crp 0.34
p.t0_v_pod 8.36e-07
p.pod_crp 6.1e-06
p.t0_crp 0.0624




Top 20 genes
Gene t0_v_pod pod_crp
CD36 9283 11160
TLR2 8950 10582
CD14 8944 10372
MYD88 8009 11413
LY96 8649 9854
TLR4 8864 9225
BTK 7100 11184
TLR1 8782 8637
TLR6 8694 7538
TIRAP 5571 6784

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BTK 7100 11184 8838
CD14 8944 10372 -5065
CD36 9283 11160 9413
LY96 8649 9854 7645
MYD88 8009 11413 3934
TIRAP 5571 6784 -3461
TLR1 8782 8637 7301
TLR2 8950 10582 9812
TLR4 8864 9225 1420
TLR6 8694 7538 2941



MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)
metric value
setSize 10
pMANOVA 2.4e-06
p.adjustMANOVA 1.46e-05
s.dist 1.27
s.t0_v_pod 0.899
s.pod_crp 0.826
s.t0_crp 0.34
p.t0_v_pod 8.36e-07
p.pod_crp 6.1e-06
p.t0_crp 0.0624




Top 20 genes
Gene t0_v_pod pod_crp
CD36 9283 11160
TLR2 8950 10582
CD14 8944 10372
MYD88 8009 11413
LY96 8649 9854
TLR4 8864 9225
BTK 7100 11184
TLR1 8782 8637
TLR6 8694 7538
TIRAP 5571 6784

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BTK 7100 11184 8838
CD14 8944 10372 -5065
CD36 9283 11160 9413
LY96 8649 9854 7645
MYD88 8009 11413 3934
TIRAP 5571 6784 -3461
TLR1 8782 8637 7301
TLR2 8950 10582 9812
TLR4 8864 9225 1420
TLR6 8694 7538 2941



alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
metric value
setSize 12
pMANOVA 2.9e-05
p.adjustMANOVA 0.000125
s.dist 1.03
s.t0_v_pod 0.785
s.pod_crp 0.642
s.t0_crp 0.198
p.t0_v_pod 2.48e-06
p.pod_crp 0.000118
p.t0_crp 0.235




Top 20 genes
Gene t0_v_pod pod_crp
ACSL1 9060 10631
ACAA1 8162 11375
ACOT8 7896 10633
HSD17B4 8710 9531
ELOVL3 8568 9494
FADS1 7583 10137
ACOX1 8711 8327
ELOVL1 6984 10145
ABCD1 7236 6071
ELOVL5 5930 2279
FADS2 1476 5602

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ABCD1 7236 6071 -8572
ACAA1 8162 11375 -2561
ACOT8 7896 10633 -6616
ACOX1 8711 8327 6705
ACSL1 9060 10631 6892
ELOVL1 6984 10145 -1725
ELOVL3 8568 9494 10343
ELOVL5 5930 2279 6278
FADS1 7583 10137 5863
FADS2 1476 5602 422
HSD17B4 8710 9531 7514
SCP2 4410 -1743 8558



alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
metric value
setSize 12
pMANOVA 2.9e-05
p.adjustMANOVA 0.000125
s.dist 1.03
s.t0_v_pod 0.785
s.pod_crp 0.642
s.t0_crp 0.198
p.t0_v_pod 2.48e-06
p.pod_crp 0.000118
p.t0_crp 0.235




Top 20 genes
Gene t0_v_pod pod_crp
ACSL1 9060 10631
ACAA1 8162 11375
ACOT8 7896 10633
HSD17B4 8710 9531
ELOVL3 8568 9494
FADS1 7583 10137
ACOX1 8711 8327
ELOVL1 6984 10145
ABCD1 7236 6071
ELOVL5 5930 2279
FADS2 1476 5602

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ABCD1 7236 6071 -8572
ACAA1 8162 11375 -2561
ACOT8 7896 10633 -6616
ACOX1 8711 8327 6705
ACSL1 9060 10631 6892
ELOVL1 6984 10145 -1725
ELOVL3 8568 9494 10343
ELOVL5 5930 2279 6278
FADS1 7583 10137 5863
FADS2 1476 5602 422
HSD17B4 8710 9531 7514
SCP2 4410 -1743 8558



Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand
metric value
setSize 11
pMANOVA 0.000123
p.adjustMANOVA 0.000452
s.dist 1.01
s.t0_v_pod 0.743
s.pod_crp 0.626
s.t0_crp 0.269
p.t0_v_pod 1.95e-05
p.pod_crp 0.000322
p.t0_crp 0.122




Top 20 genes
Gene t0_v_pod pod_crp
S100A9 9353 11235
S100A8 9341 11121
CD36 9283 11160
TLR2 8950 10582
CD14 8944 10372
LY96 8649 9854
TLR4 8864 9225
TLR1 8782 8637
TLR6 8694 7538

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CD14 8944 10372 -5065
CD36 9283 11160 9413
HMGB1 -251 -7642 4980
LY96 8649 9854 7645
S100A1 -7825 890 -2805
S100A8 9341 11121 2853
S100A9 9353 11235 226
TLR1 8782 8637 7301
TLR2 8950 10582 9812
TLR4 8864 9225 1420
TLR6 8694 7538 2941



Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse
metric value
setSize 24
pMANOVA 2.63e-09
p.adjustMANOVA 2.99e-08
s.dist 0.994
s.t0_v_pod -0.743
s.pod_crp -0.66
s.t0_crp -0.00808
p.t0_v_pod 2.86e-10
p.pod_crp 2.12e-08
p.t0_crp 0.945




Top 20 genes
Gene t0_v_pod pod_crp
CD247 -11982 -9454
LCK -11482 -9442
TRAC -11130 -9287
CD3E -10952 -9335
CD3G -11173 -9082
TRBC1 -11646 -8623
ZAP70 -11590 -8619
TRBV12-3 -10099 -9681
CD3D -11049 -8704
TRAV19 -9587 -9353
HLA-DPB1 -11887 -7068
HLA-DQB2 -9085 -8978
TRAV29DV5 -9353 -8284
HLA-DRA -11649 -6573
HLA-DPA1 -11954 -5815
TRBV7-9 -9220 -6700
TRAV8-4 -7010 -7565
HLA-DQA2 -4652 -9364
CD4 -5228 -4848
HLA-DQA1 -11633 -1453

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CD247 -11982 -9454 -8935
CD3D -11049 -8704 2046
CD3E -10952 -9335 5813
CD3G -11173 -9082 6756
CD4 -5228 -4848 -1251
HLA-DPA1 -11954 -5815 946
HLA-DPB1 -11887 -7068 -7160
HLA-DQA1 -11633 -1453 9693
HLA-DQA2 -4652 -9364 -9927
HLA-DQB1 -6199 3626 5107
HLA-DQB2 -9085 -8978 -9720
HLA-DRA -11649 -6573 2695
HLA-DRB1 -7792 1344 9366
HLA-DRB5 -4806 -1108 9092
LCK -11482 -9442 -4194
PTPN22 -1191 5545 9392
TRAC -11130 -9287 8688
TRAV19 -9587 -9353 -6593
TRAV29DV5 -9353 -8284 4257
TRAV8-4 -7010 -7565 10068
TRBC1 -11646 -8623 -1744
TRBV12-3 -10099 -9681 -6812
TRBV7-9 -9220 -6700 -5268
ZAP70 -11590 -8619 -9003



Peptide chain elongation

Peptide chain elongation
metric value
setSize 88
pMANOVA 1.95e-48
p.adjustMANOVA 2.41e-46
s.dist 0.986
s.t0_v_pod -0.281
s.pod_crp -0.702
s.t0_crp -0.633
p.t0_v_pod 5.05e-06
p.pod_crp 4.04e-30
p.t0_crp 9.1e-25




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
EEF1A1 -9346 -7605
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EEF2 -7032 -9881
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EEF1A1 -4918 -9346 -7605
EEF2 304 -7032 -9881
FAU -359 -1018 -9018
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
metric value
setSize 93
pMANOVA 3.79e-51
p.adjustMANOVA 1.03e-48
s.dist 0.98
s.t0_v_pod -0.273
s.pod_crp -0.701
s.t0_crp -0.629
p.t0_v_pod 5.39e-06
p.pod_crp 1.34e-31
p.t0_crp 8.59e-26




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
EEF1G -8918 -9825
EEF1B2 -9047 -9449
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
EEF1A1 -9346 -7605
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EEF2 -7032 -9881
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EEF1A1 -4918 -9346 -7605
EEF1A1P5 -1889 -6556 -5446
EEF1A2 -4993 -1930 7579
EEF1B2 -4128 -9047 -9449
EEF1D -805 -4960 -9517
EEF1G -1364 -8918 -9825
EEF2 304 -7032 -9881
FAU -359 -1018 -9018
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
metric value
setSize 11
pMANOVA 6.64e-05
p.adjustMANOVA 0.000259
s.dist 0.965
s.t0_v_pod 0.67
s.pod_crp 0.576
s.t0_crp -0.389
p.t0_v_pod 0.000119
p.pod_crp 0.000945
p.t0_crp 0.0256




Top 20 genes
Gene t0_v_pod pod_crp
FZD5 9350 11494
CLTC 8849 9216
AP2A1 6737 11502
AP2S1 7903 9372
AP2A2 7150 10268
CLTA 8244 7587
AP2M1 8486 7237
CLTB 6002 8174
FZD2 6374 3945

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AP2A1 6737 11502 -6569
AP2A2 7150 10268 -7534
AP2B1 -2641 -3659 -3248
AP2M1 8486 7237 -8627
AP2S1 7903 9372 -3704
CLTA 8244 7587 492
CLTB 6002 8174 -8503
CLTC 8849 9216 1230
FZD2 6374 3945 -6834
FZD5 9350 11494 1416
ROR1 -2323 1889 3248



Selenocysteine synthesis

Selenocysteine synthesis
metric value
setSize 92
pMANOVA 4.47e-45
p.adjustMANOVA 3.31e-43
s.dist 0.948
s.t0_v_pod -0.299
s.pod_crp -0.68
s.t0_crp -0.59
p.t0_v_pod 7.43e-07
p.pod_crp 1.63e-29
p.t0_crp 1.27e-22




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EEFSEC -9700 -5202 -5033
FAU -359 -1018 -9018
PSTK -9857 -3048 -2424
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SARS1 -5712 -6385 -5849
SECISBP2 -9999 -6029 7107
SEPHS2 7535 7158 -56
SEPSECS -10939 -7023 6762
UBA52 1112 -1425 -7104



Viral mRNA Translation

Viral mRNA Translation
metric value
setSize 88
pMANOVA 4.24e-45
p.adjustMANOVA 3.31e-43
s.dist 0.945
s.t0_v_pod -0.262
s.pod_crp -0.679
s.t0_crp -0.602
p.t0_v_pod 2.13e-05
p.pod_crp 2.75e-28
p.t0_crp 1.45e-22




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
DNAJC3 8302 8189 7460
FAU -359 -1018 -9018
GRSF1 5110 -3098 3896
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



Eukaryotic Translation Termination

Eukaryotic Translation Termination
metric value
setSize 92
pMANOVA 5.58e-46
p.adjustMANOVA 5.43e-44
s.dist 0.936
s.t0_v_pod -0.265
s.pod_crp -0.674
s.t0_crp -0.593
p.t0_v_pod 1.13e-05
p.pod_crp 4.4e-29
p.t0_crp 7.6e-23




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
APEH 989 4413 -8349
ETF1 7308 4260 7904
FAU -359 -1018 -9018
GSPT1 6387 -6536 7223
GSPT2 -10067 -8294 -945
N6AMT1 -10964 -8846 239
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
TRMT112 732 -366 -8610
UBA52 1112 -1425 -7104



Hyaluronan uptake and degradation

Hyaluronan uptake and degradation
metric value
setSize 10
pMANOVA 0.000489
p.adjustMANOVA 0.00146
s.dist 0.918
s.t0_v_pod 0.729
s.pod_crp 0.514
s.t0_crp -0.217
p.t0_v_pod 6.53e-05
p.pod_crp 0.00489
p.t0_crp 0.234




Top 20 genes
Gene t0_v_pod pod_crp
HYAL2 8935 11497
SLC9A1 7847 11292
GUSB 7607 11238
CHP1 9101 9267
CD44 8201 8363
HEXB 8631 6847
HYAL1 4123 8509
HYAL3 5168 304

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CD44 8201 8363 1308
CHP1 9101 9267 -2016
GUSB 7607 11238 -5640
HEXA 1251 -437 -3967
HEXB 8631 6847 3887
HMMR 3770 -3451 3745
HYAL1 4123 8509 6499
HYAL2 8935 11497 -6474
HYAL3 5168 304 -7308
SLC9A1 7847 11292 -6860



Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
metric value
setSize 100
pMANOVA 3.12e-52
p.adjustMANOVA 1.06e-49
s.dist 0.914
s.t0_v_pod -0.208
s.pod_crp -0.677
s.t0_crp -0.577
p.t0_v_pod 0.000327
p.pod_crp 1.03e-31
p.t0_crp 1.85e-23




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
EIF3B -8831 -8507
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EIF3L -7724 -8957
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
FAU -359 -1018 -9018
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
metric value
setSize 94
pMANOVA 2.69e-43
p.adjustMANOVA 1.83e-41
s.dist 0.89
s.t0_v_pod -0.244
s.pod_crp -0.653
s.t0_crp -0.553
p.t0_v_pod 4.23e-05
p.pod_crp 6.26e-28
p.t0_crp 1.92e-20




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF4G1 7908 9779 -6766
ETF1 7308 4260 7904
FAU -359 -1018 -9018
GSPT1 6387 -6536 7223
GSPT2 -10067 -8294 -945
NCBP1 -5659 -1114 10474
NCBP2 -9239 -8170 10809
PABPC1 5290 -3454 4415
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104
UPF1 4629 6901 -6523



Unwinding of DNA

Unwinding of DNA
metric value
setSize 12
pMANOVA 0.000824
p.adjustMANOVA 0.00233
s.dist 0.886
s.t0_v_pod -0.637
s.pod_crp -0.614
s.t0_crp -0.0512
p.t0_v_pod 0.000133
p.pod_crp 0.000229
p.t0_crp 0.759




Top 20 genes
Gene t0_v_pod pod_crp
MCM3 -11839 -9726
MCM7 -11768 -7678
MCM6 -9393 -9254
GINS4 -9903 -8158
MCM8 -10599 -6098
MCM4 -8404 -7585
MCM2 -6973 -7515
GINS3 -10170 -3967
GINS2 -4661 -3252
CDC45 -2594 -5606
GINS1 -4261 -966

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CDC45 -2594 -5606 408
GINS1 -4261 -966 8820
GINS2 -4661 -3252 3986
GINS3 -10170 -3967 4589
GINS4 -9903 -8158 136
MCM2 -6973 -7515 -6936
MCM3 -11839 -9726 -2416
MCM4 -8404 -7585 -850
MCM5 -7039 1270 -7307
MCM6 -9393 -9254 448
MCM7 -11768 -7678 -3106
MCM8 -10599 -6098 3359



Uptake and function of anthrax toxins

Uptake and function of anthrax toxins
metric value
setSize 10
pMANOVA 0.000939
p.adjustMANOVA 0.0026
s.dist 0.85
s.t0_v_pod 0.704
s.pod_crp 0.433
s.t0_crp -0.2
p.t0_v_pod 0.000117
p.pod_crp 0.0178
p.t0_crp 0.274




Top 20 genes
Gene t0_v_pod pod_crp
FURIN 8922 10150
MAP2K1 8910 10086
MAP2K6 8739 10133
MAP2K3 8604 9627
PDCD6IP 6440 8445
MAP2K2 6699 5024
MAP2K4 6770 4537
ANTXR2 7221 773
MAP2K7 1641 1095

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ANTXR2 7221 773 -4662
CALM1 -2039 -5114 3302
FURIN 8922 10150 -9942
MAP2K1 8910 10086 -3295
MAP2K2 6699 5024 -9806
MAP2K3 8604 9627 -5657
MAP2K4 6770 4537 4618
MAP2K6 8739 10133 8244
MAP2K7 1641 1095 -8952
PDCD6IP 6440 8445 11228



MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
metric value
setSize 10
pMANOVA 0.00432
p.adjustMANOVA 0.00968
s.dist 0.833
s.t0_v_pod 0.53
s.pod_crp 0.515
s.t0_crp 0.385
p.t0_v_pod 0.00371
p.pod_crp 0.00484
p.t0_crp 0.0352




Top 20 genes
Gene t0_v_pod pod_crp
GRB2 9146 10742
RAC1 8647 10726
HGF 8715 10153
CRK 8756 9243
GAB1 5607 9590
RAP1A 7198 6943
RAP1B 3179 5307

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CRK 8756 9243 8031
CRKL 3927 -235 -3231
DOCK7 -2317 -2789 6036
GAB1 5607 9590 8595
GRB2 9146 10742 73
HGF 8715 10153 7901
RAC1 8647 10726 9288
RAP1A 7198 6943 11289
RAP1B 3179 5307 7206
RAPGEF1 -9501 3813 -7683



VLDLR internalisation and degradation

VLDLR internalisation and degradation
metric value
setSize 11
pMANOVA 0.00035
p.adjustMANOVA 0.00112
s.dist 0.83
s.t0_v_pod 0.468
s.pod_crp 0.484
s.t0_crp -0.486
p.t0_v_pod 0.00718
p.pod_crp 0.00547
p.t0_crp 0.00527




Top 20 genes
Gene t0_crp pod_crp
NR1H2 -8719 9255
AP2A2 -7534 10268
AP2A1 -6569 11502
AP2M1 -8627 7237
AP2S1 -3704 9372
VLDLR -4084 7505
NR1H3 -4706 5401

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AP2A1 6737 11502 -6569
AP2A2 7150 10268 -7534
AP2B1 -2641 -3659 -3248
AP2M1 8486 7237 -8627
AP2S1 7903 9372 -3704
CLTA 8244 7587 492
CLTC 8849 9216 1230
MYLIP -3870 -7475 -4584
NR1H2 7304 9255 -8719
NR1H3 -3491 5401 -4706
VLDLR -4246 7505 -4084



Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
metric value
setSize 100
pMANOVA 5.74e-41
p.adjustMANOVA 3.72e-39
s.dist 0.827
s.t0_v_pod -0.222
s.pod_crp -0.628
s.t0_crp -0.49
p.t0_v_pod 0.000128
p.pod_crp 1.65e-27
p.t0_crp 2.35e-17




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ASNS -8030 -6156 8887
ATF2 2072 -4907 10911
ATF3 -9357 -2868 434
ATF4 6151 -983 -3406
CEBPB 7875 10842 597
CEBPG 5401 1944 10708
DDIT3 4850 3470 2876
EIF2AK4 41 -1588 -1986
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
FAU -359 -1018 -9018
GCN1 -10036 -6501 -4215
IMPACT -3125 -6727 10238
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
TRIB3 -5649 -1353 -1340
UBA52 1112 -1425 -7104



L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
metric value
setSize 110
pMANOVA 7.42e-50
p.adjustMANOVA 1.26e-47
s.dist 0.812
s.t0_v_pod -0.143
s.pod_crp -0.621
s.t0_crp -0.503
p.t0_v_pod 0.00949
p.pod_crp 1.83e-29
p.t0_crp 7.74e-20




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
EIF3B -8831 -8507
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EIF3L -7724 -8957
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
FAU -359 -1018 -9018
PABPC1 5290 -3454 4415
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
metric value
setSize 111
pMANOVA 1.02e-48
p.adjustMANOVA 1.38e-46
s.dist 0.8
s.t0_v_pod -0.147
s.pod_crp -0.619
s.t0_crp -0.486
p.t0_v_pod 0.00738
p.pod_crp 1.7e-29
p.t0_crp 9.15e-19




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
EIF3B -8831 -8507
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EIF3L -7724 -8957
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
EIF5 2162 -411 10513
EIF5B -4487 -5892 9461
FAU -359 -1018 -9018
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4
metric value
setSize 13
pMANOVA 0.000126
p.adjustMANOVA 0.000461
s.dist 0.798
s.t0_v_pod 0.449
s.pod_crp 0.425
s.t0_crp -0.505
p.t0_v_pod 0.00507
p.pod_crp 0.00803
p.t0_crp 0.00161




Top 20 genes
Gene t0_crp t0_v_pod
AP2M1 -8627 8486
PRKCB -7987 6993
AP2A2 -7534 7150
CLTB -8503 6002
AP2A1 -6569 6737
ARRB2 -5123 8355
AP2S1 -3704 7903
PRKCA -5853 1123

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AP2A1 6737 11502 -6569
AP2A2 7150 10268 -7534
AP2B1 -2641 -3659 -3248
AP2M1 8486 7237 -8627
AP2S1 7903 9372 -3704
ARRB2 8355 10835 -5123
CLTA 8244 7587 492
CLTB 6002 8174 -8503
CLTC 8849 9216 1230
DVL2 -10804 -4871 -9045
FZD4 -11295 2975 2621
PRKCA 1123 -5628 -5853
PRKCB 6993 7023 -7987



Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling
metric value
setSize 12
pMANOVA 0.00138
p.adjustMANOVA 0.00359
s.dist 0.798
s.t0_v_pod 0.65
s.pod_crp 0.456
s.t0_crp -0.0797
p.t0_v_pod 9.71e-05
p.pod_crp 0.00619
p.t0_crp 0.633




Top 20 genes
Gene t0_v_pod pod_crp
S100A12 9352 10889
MAPK3 8803 9501
LGALS3 8608 9166
MAPK1 7381 10667
CAPZA2 8457 7902
CAPZA1 8008 7934
DDOST 6831 7376
APP 9022 3287
PRKCSH 5159 5638
AGER 1284 7637

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AGER 1284 7637 228
APP 9022 3287 -2433
CAPZA1 8008 7934 10601
CAPZA2 8457 7902 9795
DDOST 6831 7376 -7998
HMGB1 -251 -7642 4980
LGALS3 8608 9166 230
MAPK1 7381 10667 -1770
MAPK3 8803 9501 -9768
PRKCSH 5159 5638 -9511
S100A12 9352 10889 3333
S100B -5273 -3630 -217



Gap junction trafficking

Gap junction trafficking
metric value
setSize 13
pMANOVA 0.000739
p.adjustMANOVA 0.00212
s.dist 0.781
s.t0_v_pod 0.564
s.pod_crp 0.455
s.t0_crp -0.292
p.t0_v_pod 0.000432
p.pod_crp 0.00448
p.t0_crp 0.0683




Top 20 genes
Gene t0_v_pod pod_crp
DAB2 7985 10708
GJD3 7874 10701
CLTC 8849 9216
CLTCL1 8815 8901
CLTA 8244 7587
AP2M1 8486 7237
DNM2 6007 9598
CLTB 6002 8174
DNM1 3555 5772
GJC1 512 5804
GJC2 1074 2370

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AP2M1 8486 7237 -8627
CLTA 8244 7587 492
CLTB 6002 8174 -8503
CLTC 8849 9216 1230
CLTCL1 8815 8901 -5432
DAB2 7985 10708 -7018
DNM1 3555 5772 7505
DNM2 6007 9598 -9051
GJB6 4708 -4124 -9998
GJC1 512 5804 1908
GJC2 1074 2370 -2725
GJD3 7874 10701 1754
MYO6 -11058 -7648 6236



PD-1 signaling

PD-1 signaling
metric value
setSize 28
pMANOVA 9.24e-07
p.adjustMANOVA 6.32e-06
s.dist 0.781
s.t0_v_pod -0.579
s.pod_crp -0.524
s.t0_crp 0.00712
p.t0_v_pod 1.13e-07
p.pod_crp 1.55e-06
p.t0_crp 0.948




Top 20 genes
Gene t0_v_pod pod_crp
CD247 -11982 -9454
LCK -11482 -9442
TRAC -11130 -9287
CD3E -10952 -9335
CD3G -11173 -9082
TRBC1 -11646 -8623
TRBV12-3 -10099 -9681
CD3D -11049 -8704
TRAV19 -9587 -9353
HLA-DPB1 -11887 -7068
HLA-DQB2 -9085 -8978
TRAV29DV5 -9353 -8284
HLA-DRA -11649 -6573
HLA-DPA1 -11954 -5815
TRBV7-9 -9220 -6700
CD274 -7301 -7386
TRAV8-4 -7010 -7565
PDCD1 -6559 -7948
HLA-DQA2 -4652 -9364
CD4 -5228 -4848

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CD247 -11982 -9454 -8935
CD274 -7301 -7386 7660
CD3D -11049 -8704 2046
CD3E -10952 -9335 5813
CD3G -11173 -9082 6756
CD4 -5228 -4848 -1251
CSK 5158 10149 -6693
HLA-DPA1 -11954 -5815 946
HLA-DPB1 -11887 -7068 -7160
HLA-DQA1 -11633 -1453 9693
HLA-DQA2 -4652 -9364 -9927
HLA-DQB1 -6199 3626 5107
HLA-DQB2 -9085 -8978 -9720
HLA-DRA -11649 -6573 2695
HLA-DRB1 -7792 1344 9366
HLA-DRB5 -4806 -1108 9092
LCK -11482 -9442 -4194
PDCD1 -6559 -7948 2964
PDCD1LG2 -3235 4094 6587
PTPN11 5253 2833 -599
PTPN6 6014 11061 -2766
TRAC -11130 -9287 8688
TRAV19 -9587 -9353 -6593
TRAV29DV5 -9353 -8284 4257
TRAV8-4 -7010 -7565 10068
TRBC1 -11646 -8623 -1744
TRBV12-3 -10099 -9681 -6812
TRBV7-9 -9220 -6700 -5268



RNA Polymerase I Promoter Opening

RNA Polymerase I Promoter Opening
metric value
setSize 19
pMANOVA 4.47e-08
p.adjustMANOVA 3.9e-07
s.dist 0.779
s.t0_v_pod 0.616
s.pod_crp 0.198
s.t0_crp -0.434
p.t0_v_pod 3.31e-06
p.pod_crp 0.135
p.t0_crp 0.00106




Top 20 genes
Gene t0_v_pod t0_crp
MAPK3 8803.0 -9768.0
H2BC12 8898.0 -8447.0
H2AJ 9214.0 -7261.0
H2BC17 7178.0 -8062.0
H2BC4 7279.0 -7646.0
H3C15 6608.5 -7756.5
H2AZ1 5955.0 -8479.0
H2BC21 9125.0 -5196.0
H2BC11 7791.0 -5526.0
H2BC9 5332.0 -6635.0
H2AC6 7813.0 -4205.0
H2BC5 7881.0 -2937.0
H2BC15 5251.0 -4235.0

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All member genes
t0_v_pod pod_crp t0_crp
H2AC20 4913.0 8671.0 3752.0
H2AC6 7813.0 -1814.0 -4205.0
H2AJ 9214.0 11405.0 -7261.0
H2AZ1 5955.0 2933.0 -8479.0
H2AZ2 -1192.0 -5862.0 -2370.0
H2BC11 7791.0 3262.0 -5526.0
H2BC12 8898.0 6037.0 -8447.0
H2BC15 5251.0 523.0 -4235.0
H2BC17 7178.0 3760.0 -8062.0
H2BC21 9125.0 6114.0 -5196.0
H2BC4 7279.0 4199.0 -7646.0
H2BC5 7881.0 4394.0 -2937.0
H2BC9 5332.0 -6224.0 -6635.0
H2BU1 -6332.0 -2185.0 2615.0
H3-3A 8519.0 7532.0 5003.0
H3C15 6608.5 6537.5 -7756.5
MAPK3 8803.0 9501.0 -9768.0
MBD2 6491.0 6444.0 9027.0
UBTF -9703.0 -8842.0 -7719.0



Activation of the pre-replicative complex

Activation of the pre-replicative complex
metric value
setSize 32
pMANOVA 2.09e-08
p.adjustMANOVA 1.96e-07
s.dist 0.771
s.t0_v_pod -0.482
s.pod_crp -0.579
s.t0_crp 0.166
p.t0_v_pod 2.37e-06
p.pod_crp 1.45e-08
p.t0_crp 0.105




Top 20 genes
Gene pod_crp t0_v_pod
MCM3 -9726 -11839
POLA1 -9617 -11789
RPA1 -9614 -11644
POLE3 -8881 -11228
MCM7 -7678 -11768
DBF4 -8441 -10581
MCM6 -9254 -9393
PRIM1 -8226 -9858
ORC3 -7526 -10371
ORC2 -8055 -9594
ORC5 -8047 -9161
POLA2 -6182 -11222
RPA3 -8027 -8609
MCM8 -6098 -10599
MCM4 -7585 -8404
POLE2 -6619 -9613
MCM2 -7515 -6973
PRIM2 -5615 -5389
RPA2 -4586 -6094
CDK2 -3663 -4840

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All member genes
t0_v_pod pod_crp t0_crp
CDC45 -2594 -5606 408
CDC6 2356 -5442 5857
CDC7 -7583 813 3389
CDK2 -4840 -3663 2221
CDT1 -285 -4001 -2179
DBF4 -10581 -8441 10866
GMNN 1412 5224 7502
MCM10 769 -6736 2954
MCM2 -6973 -7515 -6936
MCM3 -11839 -9726 -2416
MCM4 -8404 -7585 -850
MCM5 -7039 1270 -7307
MCM6 -9393 -9254 448
MCM7 -11768 -7678 -3106
MCM8 -10599 -6098 3359
ORC1 -2459 -5122 968
ORC2 -9594 -8055 7100
ORC3 -10371 -7526 10738
ORC4 -1988 -5653 9250
ORC5 -9161 -8047 9437
ORC6 1174 8434 1504
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POLE -7317 -1466 -857
POLE2 -9613 -6619 10055
POLE3 -11228 -8881 -6530
POLE4 5453 -1174 -1480
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
metric value
setSize 10
pMANOVA 0.0158
p.adjustMANOVA 0.0299
s.dist 0.762
s.t0_v_pod 0.528
s.pod_crp 0.549
s.t0_crp 0.0138
p.t0_v_pod 0.00386
p.pod_crp 0.00264
p.t0_crp 0.94




Top 20 genes
Gene pod_crp t0_v_pod
NCSTN 11510 9030
PSEN1 10691 7839
ADAM10 9006 8645
JAG1 7763 8599
APH1B 9075 6194
PSENEN 9702 5662
APH1A 2189 4092

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All member genes
t0_v_pod pod_crp t0_crp
ADAM10 8645 9006 7606
APH1A 4092 2189 -7794
APH1B 6194 9075 8475
JAG1 8599 7763 -5969
NCSTN 9030 11510 3979
NOTCH4 -5056 11286 -3210
PSEN1 7839 10691 5400
PSEN2 -7449 -3399 -8440
PSENEN 5662 9702 -1424
YWHAZ 5555 -640 9258



Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
metric value
setSize 51
pMANOVA 3.07e-23
p.adjustMANOVA 9.95e-22
s.dist 0.759
s.t0_v_pod -0.0831
s.pod_crp -0.612
s.t0_crp -0.441
p.t0_v_pod 0.305
p.pod_crp 3.87e-14
p.t0_crp 5.15e-08




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPS5 -8655 -8821
RPS12 -8359 -9089
EIF3B -8831 -8507
RPS27 -8218 -8994
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
EIF3L -7724 -8957
RPS17 -7093 -9634
RPS10 -7587 -8910
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006
RPS6 -9127 -7094
RPS23 -8292 -7435
RPS21 -6666 -9210
RPS15A -7870 -7555
RPS11 -6701 -8383
RPS28 -6389 -8638

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All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
FAU -359 -1018 -9018
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058



Retrograde neurotrophin signalling

Retrograde neurotrophin signalling
metric value
setSize 12
pMANOVA 0.00114
p.adjustMANOVA 0.0031
s.dist 0.757
s.t0_v_pod 0.566
s.pod_crp 0.378
s.t0_crp -0.33
p.t0_v_pod 0.00068
p.pod_crp 0.0235
p.t0_crp 0.0476




Top 20 genes
Gene t0_v_pod pod_crp
CLTC 8849 9216
AP2A1 6737 11502
AP2S1 7903 9372
AP2A2 7150 10268
CLTA 8244 7587
AP2M1 8486 7237
DNM2 6007 9598
DNM1 3555 5772

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All member genes
t0_v_pod pod_crp t0_crp
AP2A1 6737 11502 -6569
AP2A2 7150 10268 -7534
AP2B1 -2641 -3659 -3248
AP2M1 8486 7237 -8627
AP2S1 7903 9372 -3704
CLTA 8244 7587 492
CLTC 8849 9216 1230
DNAL4 3369 -610 -8724
DNM1 3555 5772 7505
DNM2 6007 9598 -9051
DNM3 6942 -246 -1342
NTRK1 -7910 -7418 4917



DNA strand elongation

DNA strand elongation
metric value
setSize 32
pMANOVA 2.89e-07
p.adjustMANOVA 2.15e-06
s.dist 0.751
s.t0_v_pod -0.522
s.pod_crp -0.535
s.t0_crp 0.0719
p.t0_v_pod 3.22e-07
p.pod_crp 1.59e-07
p.t0_crp 0.482




Top 20 genes
Gene pod_crp t0_v_pod
MCM3 -9726 -11839
POLA1 -9617 -11789
RPA1 -9614 -11644
POLD2 -9699 -10015
LIG1 -8575 -10705
MCM7 -7678 -11768
RFC3 -8651 -10151
MCM6 -9254 -9393
PRIM1 -8226 -9858
GINS4 -8158 -9903
RFC4 -7694 -10361
FEN1 -7081 -10254
POLA2 -6182 -11222
RPA3 -8027 -8609
MCM8 -6098 -10599
MCM4 -7585 -8404
MCM2 -7515 -6973
RFC5 -3955 -11357
GINS3 -3967 -10170
PCNA -6800 -5771

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All member genes
t0_v_pod pod_crp t0_crp
CDC45 -2594 -5606 408
DNA2 -2786 -3986 9591
FEN1 -10254 -7081 -1614
GINS1 -4261 -966 8820
GINS2 -4661 -3252 3986
GINS3 -10170 -3967 4589
GINS4 -9903 -8158 136
LIG1 -10705 -8575 -5384
MCM2 -6973 -7515 -6936
MCM3 -11839 -9726 -2416
MCM4 -8404 -7585 -850
MCM5 -7039 1270 -7307
MCM6 -9393 -9254 448
MCM7 -11768 -7678 -3106
MCM8 -10599 -6098 3359
PCNA -5771 -6800 5825
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
RFC1 -7180 -5456 9242
RFC2 4890 4788 -676
RFC3 -10151 -8651 7668
RFC4 -10361 -7694 9525
RFC5 -11357 -3955 885
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
metric value
setSize 114
pMANOVA 1.49e-38
p.adjustMANOVA 8.47e-37
s.dist 0.75
s.t0_v_pod -0.195
s.pod_crp -0.565
s.t0_crp -0.453
p.t0_v_pod 0.000316
p.pod_crp 1.92e-25
p.t0_crp 6.13e-17




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CASC3 5181 7006 -5031
DCP1A -5260 -7314 6943
EIF4A3 7166 -906 -5617
EIF4G1 7908 9779 -6766
ETF1 7308 4260 7904
FAU -359 -1018 -9018
GSPT1 6387 -6536 7223
GSPT2 -10067 -8294 -945
MAGOH 1045 -1915 -9023
MAGOHB -9011 -4014 6918
NCBP1 -5659 -1114 10474
NCBP2 -9239 -8170 10809
PABPC1 5290 -3454 4415
PNRC2 -4406 -5080 11232
PPP2CA 8104 4832 5474
PPP2R1A 4542 4551 -7355
PPP2R2A 4102 -1321 11284
RBM8A -7139 -2954 -5165
RNPS1 -11075 -6991 -5614
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SMG1 -4341 -1647 151
SMG5 5264 -1860 -6622
SMG6 -6032 -4410 -5381
SMG7 6519 9295 4117
SMG8 2894 661 6082
SMG9 204 9094 223
UBA52 1112 -1425 -7104
UPF1 4629 6901 -6523
UPF2 957 -226 10140
UPF3A -9509 -7793 -4252
UPF3B -8003 -3038 7886



Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
metric value
setSize 114
pMANOVA 1.49e-38
p.adjustMANOVA 8.47e-37
s.dist 0.75
s.t0_v_pod -0.195
s.pod_crp -0.565
s.t0_crp -0.453
p.t0_v_pod 0.000316
p.pod_crp 1.92e-25
p.t0_crp 6.13e-17




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CASC3 5181 7006 -5031
DCP1A -5260 -7314 6943
EIF4A3 7166 -906 -5617
EIF4G1 7908 9779 -6766
ETF1 7308 4260 7904
FAU -359 -1018 -9018
GSPT1 6387 -6536 7223
GSPT2 -10067 -8294 -945
MAGOH 1045 -1915 -9023
MAGOHB -9011 -4014 6918
NCBP1 -5659 -1114 10474
NCBP2 -9239 -8170 10809
PABPC1 5290 -3454 4415
PNRC2 -4406 -5080 11232
PPP2CA 8104 4832 5474
PPP2R1A 4542 4551 -7355
PPP2R2A 4102 -1321 11284
RBM8A -7139 -2954 -5165
RNPS1 -11075 -6991 -5614
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SMG1 -4341 -1647 151
SMG5 5264 -1860 -6622
SMG6 -6032 -4410 -5381
SMG7 6519 9295 4117
SMG8 2894 661 6082
SMG9 204 9094 223
UBA52 1112 -1425 -7104
UPF1 4629 6901 -6523
UPF2 957 -226 10140
UPF3A -9509 -7793 -4252
UPF3B -8003 -3038 7886



Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
metric value
setSize 118
pMANOVA 6.71e-46
p.adjustMANOVA 5.71e-44
s.dist 0.748
s.t0_v_pod -0.132
s.pod_crp -0.581
s.t0_crp -0.453
p.t0_v_pod 0.0135
p.pod_crp 1.02e-27
p.t0_crp 1.9e-17




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
EIF3B -8831 -8507
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EIF3L -7724 -8957
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2B1 -411 1596 9382
EIF2B2 3233 5014 649
EIF2B3 -7934 -4864 3092
EIF2B4 2685 6611 -4482
EIF2B5 -9484 -2402 1088
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4EBP1 5990 5279 -4330
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
EIF5 2162 -411 10513
EIF5B -4487 -5892 9461
FAU -359 -1018 -9018
PABPC1 5290 -3454 4415
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
metric value
setSize 118
pMANOVA 6.71e-46
p.adjustMANOVA 5.71e-44
s.dist 0.748
s.t0_v_pod -0.132
s.pod_crp -0.581
s.t0_crp -0.453
p.t0_v_pod 0.0135
p.pod_crp 1.02e-27
p.t0_crp 1.9e-17




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
EIF3B -8831 -8507
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
EIF3L -7724 -8957
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2B1 -411 1596 9382
EIF2B2 3233 5014 649
EIF2B3 -7934 -4864 3092
EIF2B4 2685 6611 -4482
EIF2B5 -9484 -2402 1088
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4EBP1 5990 5279 -4330
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
EIF5 2162 -411 10513
EIF5B -4487 -5892 9461
FAU -359 -1018 -9018
PABPC1 5290 -3454 4415
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
UBA52 1112 -1425 -7104



RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate WASPs and WAVEs
metric value
setSize 35
pMANOVA 1.74e-08
p.adjustMANOVA 1.7e-07
s.dist 0.739
s.t0_v_pod 0.608
s.pod_crp 0.419
s.t0_crp -0.0253
p.t0_v_pod 4.76e-10
p.pod_crp 1.77e-05
p.t0_crp 0.796




Top 20 genes
Gene t0_v_pod pod_crp
WASF1 9357 11312
CYFIP1 9108 10929
GRB2 9146 10742
ARPC1B 9102 10772
ARPC1A 8745 11015
WAS 8421 11046
RAC1 8647 10726
ACTB 8859 10253
NCKAP1L 7557 11206
ARPC5 8544 9897
MAPK3 8803 9501
WASF2 8237 10101
BTK 7100 11184
MAPK1 7381 10667
ARPC3 8147 9352
ACTG1 8423 8439
ARPC4 7404 9098
ARPC2 7280 9088
NCKAP1 7350 7775
ACTR2 7750 7266

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ABI1 6978 7570 10492
ABI2 -10571 -7769 1488
ABL1 224 4001 -7169
ACTB 8859 10253 -883
ACTG1 8423 8439 -7587
ACTR2 7750 7266 8225
ACTR3 7699 6569 7217
ARPC1A 8745 11015 5898
ARPC1B 9102 10772 -7161
ARPC2 7280 9088 4584
ARPC3 8147 9352 7298
ARPC4 7404 9098 -762
ARPC5 8544 9897 5412
BAIAP2 -215 -1219 -7114
BRK1 6929 -1993 -8775
BTK 7100 11184 8838
CDC42 7425 7251 8682
CYFIP1 9108 10929 1675
CYFIP2 -10031 -4738 -3657
GRB2 9146 10742 73
MAPK1 7381 10667 -1770
MAPK3 8803 9501 -9768
NCK1 -11102 -8778 9958
NCKAP1 7350 7775 -384
NCKAP1L 7557 11206 1696
NCKIPSD 326 -6950 -7988
PTK2 4418 -3305 -1920
RAC1 8647 10726 9288
WAS 8421 11046 -2152
WASF1 9357 11312 -1299
WASF2 8237 10101 -4920
WASF3 6713 -6442 -8154
WASL 297 -1358 7215
WIPF1 563 -3502 -5287
WIPF2 5640 6630 1702



RHO GTPases Activate ROCKs

RHO GTPases Activate ROCKs
metric value
setSize 18
pMANOVA 0.000619
p.adjustMANOVA 0.0018
s.dist 0.735
s.t0_v_pod 0.541
s.pod_crp 0.492
s.t0_crp 0.0754
p.t0_v_pod 7.03e-05
p.pod_crp 0.000304
p.t0_crp 0.58




Top 20 genes
Gene t0_v_pod pod_crp
PAK1 8100 10529
MYL6 8436 9884
CFL1 8057 9547
RHOA 8188 8640
LIMK2 7949 8071
ROCK1 7377 6942
LIMK1 4628 9134
MYH9 6594 6222
ROCK2 6054 5462
PPP1R12A 5969 4398
MYL12B 5029 4688
PPP1CB 6960 2822
PPP1R12B 1762 7010
RHOB 1244 5855
MYH10 647 7120

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CFL1 8057 9547 -7188
LIMK1 4628 9134 -7403
LIMK2 7949 8071 -2143
MYH10 647 7120 114
MYH11 -3419 -613 7159
MYH9 6594 6222 -7921
MYL12B 5029 4688 5113
MYL6 8436 9884 -8536
MYL9 7587 -4539 -5216
PAK1 8100 10529 8872
PPP1CB 6960 2822 9481
PPP1R12A 5969 4398 9348
PPP1R12B 1762 7010 895
RHOA 8188 8640 7321
RHOB 1244 5855 4267
RHOC -11009 8686 -4554
ROCK1 7377 6942 10322
ROCK2 6054 5462 6111



Signaling by Leptin

Signaling by Leptin
metric value
setSize 10
pMANOVA 0.00213
p.adjustMANOVA 0.00522
s.dist 0.733
s.t0_v_pod 0.565
s.pod_crp 0.274
s.t0_crp -0.379
p.t0_v_pod 0.00198
p.pod_crp 0.134
p.t0_crp 0.0379




Top 20 genes
Gene t0_v_pod t0_crp
SOCS3 9315 -9983
IRS2 8429 -8741
STAT5A 6864 -6998
STAT5B 6825 -5878
IRS1 1728 -9593
LEPR 6397 -1510
PTPN11 5253 -599

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
IRS1 1728 -6674 -9593
IRS2 8429 9184 -8741
JAK2 2670 3748 10899
LEPR 6397 -314 -1510
PTPN11 5253 2833 -599
SH2B1 -8374 -3069 -4387
SOCS3 9315 10466 -9983
STAT3 7972 8187 2684
STAT5A 6864 8984 -6998
STAT5B 6825 4419 -5878



RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases
metric value
setSize 21
pMANOVA 3.51e-05
p.adjustMANOVA 0.000149
s.dist 0.732
s.t0_v_pod 0.559
s.pod_crp 0.426
s.t0_crp -0.205
p.t0_v_pod 9.31e-06
p.pod_crp 0.000734
p.t0_crp 0.104




Top 20 genes
Gene t0_v_pod pod_crp
S100A9 9353 11235
S100A8 9341 11121
PRKCD 8856 11308
NCF2 9034 10855
NCF4 9111 10692
RAC1 8647 10726
MAPK14 8951 10298
CYBB 8879 10038
MAPK3 8803 9501
MAPK1 7381 10667
CYBA 6822 10446
NCF1 7224 7391
PRKCB 6993 7023
RAC2 5104 5027

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CYBA 6822 10446 -6535
CYBB 8879 10038 8462
MAPK1 7381 10667 -1770
MAPK11 3788 -269 -848
MAPK14 8951 10298 4000
MAPK3 8803 9501 -9768
NCF1 7224 7391 -3129
NCF2 9034 10855 2089
NCF4 9111 10692 -4957
NOXA1 -5279 -3222 -6522
PIK3C3 1606 -3264 6819
PIK3R4 -3937 -4378 5657
PIN1 -3103 202 -9746
PRKCA 1123 -5628 -5853
PRKCB 6993 7023 -7987
PRKCD 8856 11308 806
PRKCZ -11275 -6443 -7422
RAC1 8647 10726 9288
RAC2 5104 5027 -8160
S100A8 9341 11121 2853
S100A9 9353 11235 226



Selenoamino acid metabolism

Selenoamino acid metabolism
metric value
setSize 114
pMANOVA 4.37e-34
p.adjustMANOVA 1.92e-32
s.dist 0.731
s.t0_v_pod -0.228
s.pod_crp -0.552
s.t0_crp -0.42
p.t0_v_pod 2.52e-05
p.pod_crp 1.98e-24
p.t0_crp 8.73e-15




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AHCY 460 -2709 -8769
AIMP1 -5707 -5053 11190
AIMP2 -976 -2600 -3409
CBS 6846 10791 7233
CTH -7898 -2190 7368
DARS1 1060 -6717 10824
EEF1E1 -2031 2193 9911
EEFSEC -9700 -5202 -5033
EPRS1 -3100 -6808 7171
FAU -359 -1018 -9018
GNMT 2014 7257 -1918
GSR 9078 10593 -1642
HNMT 8186 8093 7009
IARS1 -11539 -8667 631
INMT 2159 -1929 2624
KARS1 -5204 -7603 4454
LARS1 -6211 -8836 9549
MARS1 -2525 9563 882
PAPSS1 8852 9525 9638
PAPSS2 -2738 11530 10362
PSTK -9857 -3048 -2424
QARS1 85 -3035 -9161
RARS1 -4641 -1099 10338
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SARS1 -5712 -6385 -5849
SCLY -7964 -5853 -6300
SECISBP2 -9999 -6029 7107
SEPHS2 7535 7158 -56
SEPSECS -10939 -7023 6762
TXNRD1 8062 8115 4242
UBA52 1112 -1425 -7104



Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
metric value
setSize 180
pMANOVA 1.52e-47
p.adjustMANOVA 1.6e-45
s.dist 0.725
s.t0_v_pod -0.306
s.pod_crp -0.591
s.t0_crp -0.286
p.t0_v_pod 1.3e-12
p.pod_crp 9.56e-43
p.t0_crp 3.47e-11




Top 20 genes
Gene pod_crp t0_v_pod
UTP4 -9295 -11142
BMS1 -9121 -11315
NOP14 -9676 -10522
LAS1L -8458 -11905
FBL -9628 -9855
NOP56 -8304 -11395
NOL11 -9311 -10134
NOB1 -9210 -9986
TSR1 -9680 -9409
NOP58 -9323 -9623
PDCD11 -7938 -11166
WDR75 -9170 -9593
EXOSC8 -7863 -11104
EXOSC2 -8130 -10724
IMP4 -8191 -10629
DDX47 -7920 -10949
RPL23A -9339 -9248
UTP15 -8238 -10264
TEX10 -8701 -9440
NCL -9124 -8953

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BMS1 -11315 -9121 -2978
BOP1 -5039 -5105 -9461
BYSL -4316 -5824 -5291
C1D 3484 530 10834
CSNK1D 2374 7369 -9414
CSNK1E -9964 -7485 -8511
DCAF13 -5386 -4214 -1334
DDX21 3087 -3715 7759
DDX47 -10949 -7920 10936
DDX49 4816 4154 -9489
DDX52 448 1493 11328
DHX37 -7983 -5722 -6991
DIS3 -4187 -3885 11031
EBNA1BP2 -3970 -6823 -1321
EMG1 -9856 -6694 4341
ERI1 5474 1977 9721
EXOSC1 -979 2548 5536
EXOSC10 -11028 -5076 4728
EXOSC2 -10724 -8130 -8291
EXOSC3 503 280 2174
EXOSC4 7485 8780 -6432
EXOSC5 -4428 -8229 -8152
EXOSC6 -9514 -7940 -3133
EXOSC7 -10290 -6545 -9416
EXOSC8 -11104 -7863 7938
EXOSC9 -9917 -7435 10177
FAU -359 -1018 -9018
FBL -9855 -9628 -9879
FCF1 4428 -2984 7360
FTSJ3 -3900 3485 -5754
GNL3 -8199 -9337 5789
HEATR1 -10009 -7318 1473
IMP3 -9143 -6956 -3753
IMP4 -10629 -8191 -5663
ISG20L2 3737 -42 1389
KRR1 -8329 -6392 7558
LAS1L -11905 -8458 -7799
LTV1 -4162 -4559 7450
MPHOSPH10 -7519 -6550 11244
MPHOSPH6 2168 -2313 5028
MTREX -2574 -4700 10249
NCL -8953 -9124 -4545
NIP7 -5682 -8082 5054
NOB1 -9986 -9210 -6132
NOC4L -5298 7372 -3269
NOL11 -10134 -9311 9550
NOL12 4887 5706 -708
NOL6 -10564 -6904 -9301
NOL9 -9891 -7152 4295
NOP14 -10522 -9676 -4648
NOP56 -11395 -8304 -926
NOP58 -9623 -9323 9270
PDCD11 -11166 -7938 -6311
PELP1 -10584 -7287 -1544
PES1 -1993 -5454 -8799
PNO1 -6627 -7464 6858
PWP2 -1190 -7158 -7255
RBM28 -11316 -5771 -5592
RCL1 -751 -7719 -4623
RIOK1 -3702 -3302 6967
RIOK2 927 -8363 9267
RIOK3 8621 2731 9110
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPP14 2981 -2410 8611
RPP21 -5178 -197 -7267
RPP25 -7963 -7582 -5681
RPP30 -7818 -7132 9074
RPP38 -6833 -6494 8801
RPP40 -4680 -9576 3718
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
RRP1 -3003 872 -2135
RRP36 -1645 510 -1316
RRP7A -2734 -4541 -659
RRP9 -9748 -8079 -9693
SENP3 2970 4193 -2573
SNORD3A -2477 11233 9893
SNU13 -6637 -7945 -4150
TBL3 -3341 55 -8145
TEX10 -9440 -8701 9112
TSR1 -9409 -9680 -814
UBA52 1112 -1425 -7104
UTP11 4582 1261 8086
UTP14A -1788 -3133 4462
UTP14C -2032 -1616 5210
UTP15 -10264 -8238 10459
UTP18 5055 3705 3978
UTP20 -10191 -6857 6223
UTP3 -2829 -1448 -1947
UTP4 -11142 -9295 -1037
UTP6 -4362 -5407 9675
WDR12 5156 -1289 5359
WDR18 -2260 -4315 -6073
WDR3 -6394 -7931 -33
WDR36 -3825 -5814 6003
WDR43 -7419 -8808 3001
WDR46 -10623 -6936 -9396
WDR75 -9593 -9170 7264
XRN2 9240 9220 2754



Activation of ATR in response to replication stress

Activation of ATR in response to replication stress
metric value
setSize 36
pMANOVA 9.68e-09
p.adjustMANOVA 1.03e-07
s.dist 0.724
s.t0_v_pod -0.452
s.pod_crp -0.506
s.t0_crp 0.253
p.t0_v_pod 2.73e-06
p.pod_crp 1.52e-07
p.t0_crp 0.0085




Top 20 genes
Gene pod_crp t0_v_pod
MCM3 -9726 -11839
RPA1 -9614 -11644
RAD1 -9428 -11845
MCM7 -7678 -11768
DBF4 -8441 -10581
RFC3 -8651 -10151
MCM6 -9254 -9393
RFC4 -7694 -10361
ORC3 -7526 -10371
ORC2 -8055 -9594
RAD17 -7700 -9973
ORC5 -8047 -9161
RPA3 -8027 -8609
MCM8 -6098 -10599
MCM4 -7585 -8404
RAD9A -5038 -11083
MCM2 -7515 -6973
RFC5 -3955 -11357
RPA2 -4586 -6094
ATR -2758 -10018

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ATR -10018 -2758 4723
ATRIP -11134 -1507 2195
CDC25A 2888 -2524 -3404
CDC45 -2594 -5606 408
CDC6 2356 -5442 5857
CDC7 -7583 813 3389
CDK2 -4840 -3663 2221
CHEK1 -2421 -5997 7494
CLSPN 3606 -175 9061
DBF4 -10581 -8441 10866
HUS1 -145 2310 8792
MCM10 769 -6736 2954
MCM2 -6973 -7515 -6936
MCM3 -11839 -9726 -2416
MCM4 -8404 -7585 -850
MCM5 -7039 1270 -7307
MCM6 -9393 -9254 448
MCM7 -11768 -7678 -3106
MCM8 -10599 -6098 3359
ORC1 -2459 -5122 968
ORC2 -9594 -8055 7100
ORC3 -10371 -7526 10738
ORC4 -1988 -5653 9250
ORC5 -9161 -8047 9437
ORC6 1174 8434 1504
RAD1 -11845 -9428 6550
RAD17 -9973 -7700 9580
RAD9A -11083 -5038 -1689
RAD9B 3065 8595 8891
RFC2 4890 4788 -676
RFC3 -10151 -8651 7668
RFC4 -10361 -7694 9525
RFC5 -11357 -3955 885
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
metric value
setSize 190
pMANOVA 1.28e-49
p.adjustMANOVA 1.94e-47
s.dist 0.723
s.t0_v_pod -0.307
s.pod_crp -0.587
s.t0_crp -0.288
p.t0_v_pod 2.77e-13
p.pod_crp 1.77e-44
p.t0_crp 7.7e-12




Top 20 genes
Gene pod_crp t0_v_pod
DKC1 -9791 -11282
NAT10 -9283 -11593
UTP4 -9295 -11142
BMS1 -9121 -11315
NOP14 -9676 -10522
LAS1L -8458 -11905
FBL -9628 -9855
NOP56 -8304 -11395
NOL11 -9311 -10134
NOB1 -9210 -9986
TSR1 -9680 -9409
NOP58 -9323 -9623
PDCD11 -7938 -11166
WDR75 -9170 -9593
THUMPD1 -9268 -9477
EXOSC8 -7863 -11104
EXOSC2 -8130 -10724
IMP4 -8191 -10629
DDX47 -7920 -10949
RPL23A -9339 -9248

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BMS1 -11315 -9121 -2978
BOP1 -5039 -5105 -9461
BYSL -4316 -5824 -5291
C1D 3484 530 10834
CSNK1D 2374 7369 -9414
CSNK1E -9964 -7485 -8511
DCAF13 -5386 -4214 -1334
DDX21 3087 -3715 7759
DDX47 -10949 -7920 10936
DDX49 4816 4154 -9489
DDX52 448 1493 11328
DHX37 -7983 -5722 -6991
DIMT1 -7711 -9187 9761
DIS3 -4187 -3885 11031
DKC1 -11282 -9791 -2099
EBNA1BP2 -3970 -6823 -1321
EMG1 -9856 -6694 4341
ERI1 5474 1977 9721
EXOSC1 -979 2548 5536
EXOSC10 -11028 -5076 4728
EXOSC2 -10724 -8130 -8291
EXOSC3 503 280 2174
EXOSC4 7485 8780 -6432
EXOSC5 -4428 -8229 -8152
EXOSC6 -9514 -7940 -3133
EXOSC7 -10290 -6545 -9416
EXOSC8 -11104 -7863 7938
EXOSC9 -9917 -7435 10177
FAU -359 -1018 -9018
FBL -9855 -9628 -9879
FCF1 4428 -2984 7360
FTSJ3 -3900 3485 -5754
GAR1 -6703 -6656 -530
GNL3 -8199 -9337 5789
HEATR1 -10009 -7318 1473
IMP3 -9143 -6956 -3753
IMP4 -10629 -8191 -5663
ISG20L2 3737 -42 1389
KRR1 -8329 -6392 7558
LAS1L -11905 -8458 -7799
LTV1 -4162 -4559 7450
MPHOSPH10 -7519 -6550 11244
MPHOSPH6 2168 -2313 5028
MTREX -2574 -4700 10249
NAT10 -11593 -9283 -5917
NCL -8953 -9124 -4545
NHP2 -3373 -5708 -7073
NIP7 -5682 -8082 5054
NOB1 -9986 -9210 -6132
NOC4L -5298 7372 -3269
NOL11 -10134 -9311 9550
NOL12 4887 5706 -708
NOL6 -10564 -6904 -9301
NOL9 -9891 -7152 4295
NOP10 8200 10614 -3974
NOP14 -10522 -9676 -4648
NOP2 -9624 -6235 -7727
NOP56 -11395 -8304 -926
NOP58 -9623 -9323 9270
PDCD11 -11166 -7938 -6311
PELP1 -10584 -7287 -1544
PES1 -1993 -5454 -8799
PNO1 -6627 -7464 6858
PWP2 -1190 -7158 -7255
RBM28 -11316 -5771 -5592
RCL1 -751 -7719 -4623
RIOK1 -3702 -3302 6967
RIOK2 927 -8363 9267
RIOK3 8621 2731 9110
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPP14 2981 -2410 8611
RPP21 -5178 -197 -7267
RPP25 -7963 -7582 -5681
RPP30 -7818 -7132 9074
RPP38 -6833 -6494 8801
RPP40 -4680 -9576 3718
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
RRP1 -3003 872 -2135
RRP36 -1645 510 -1316
RRP7A -2734 -4541 -659
RRP9 -9748 -8079 -9693
SENP3 2970 4193 -2573
SNORD3A -2477 11233 9893
SNU13 -6637 -7945 -4150
TBL3 -3341 55 -8145
TEX10 -9440 -8701 9112
THUMPD1 -9477 -9268 8192
TRMT112 732 -366 -8610
TSR1 -9409 -9680 -814
TSR3 3808 -354 -8970
UBA52 1112 -1425 -7104
UTP11 4582 1261 8086
UTP14A -1788 -3133 4462
UTP14C -2032 -1616 5210
UTP15 -10264 -8238 10459
UTP18 5055 3705 3978
UTP20 -10191 -6857 6223
UTP3 -2829 -1448 -1947
UTP4 -11142 -9295 -1037
UTP6 -4362 -5407 9675
WDR12 5156 -1289 5359
WDR18 -2260 -4315 -6073
WDR3 -6394 -7931 -33
WDR36 -3825 -5814 6003
WDR43 -7419 -8808 3001
WDR46 -10623 -6936 -9396
WDR75 -9593 -9170 7264
XRN2 9240 9220 2754



DNA methylation

DNA methylation
metric value
setSize 20
pMANOVA 7.18e-08
p.adjustMANOVA 5.96e-07
s.dist 0.722
s.t0_v_pod 0.517
s.pod_crp 0.109
s.t0_crp -0.493
p.t0_v_pod 6.35e-05
p.pod_crp 0.398
p.t0_crp 0.000135




Top 20 genes
Gene t0_v_pod t0_crp
H2BC12 8898.0 -8447.0
H2AJ 9214.0 -7261.0
H2BC17 7178.0 -8062.0
H2BC4 7279.0 -7646.0
H3C15 6608.5 -7756.5
H2AZ1 5955.0 -8479.0
H2BC21 9125.0 -5196.0
H2BC11 7791.0 -5526.0
DNMT3B 4250.0 -9551.0
H2BC9 5332.0 -6635.0
H2AC6 7813.0 -4205.0
H2BC5 7881.0 -2937.0
H2BC15 5251.0 -4235.0

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
DNMT1 -11896.0 -9160.0 -8442.0
DNMT3A -2963.0 -4703.0 -8387.0
DNMT3B 4250.0 3253.0 -9551.0
H2AC20 4913.0 8671.0 3752.0
H2AC6 7813.0 -1814.0 -4205.0
H2AJ 9214.0 11405.0 -7261.0
H2AZ1 5955.0 2933.0 -8479.0
H2AZ2 -1192.0 -5862.0 -2370.0
H2BC11 7791.0 3262.0 -5526.0
H2BC12 8898.0 6037.0 -8447.0
H2BC15 5251.0 523.0 -4235.0
H2BC17 7178.0 3760.0 -8062.0
H2BC21 9125.0 6114.0 -5196.0
H2BC4 7279.0 4199.0 -7646.0
H2BC5 7881.0 4394.0 -2937.0
H2BC9 5332.0 -6224.0 -6635.0
H2BU1 -6332.0 -2185.0 2615.0
H3-3A 8519.0 7532.0 5003.0
H3C15 6608.5 6537.5 -7756.5
UHRF1 168.0 1689.0 1295.0



Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen
metric value
setSize 11
pMANOVA 0.000153
p.adjustMANOVA 0.000541
s.dist 0.72
s.t0_v_pod 0.68
s.pod_crp 0.2
s.t0_crp -0.131
p.t0_v_pod 9.48e-05
p.pod_crp 0.251
p.t0_crp 0.452




Top 20 genes
Gene t0_v_pod pod_crp
CYB5R1 9299 10194
CYB5R2 8460 8847
CYB5R4 8289 8151
AQP1 7364 6140
CA4 2804 10269
CA1 9220 469

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AQP1 7364 6140 -2835
CA1 9220 469 3952
CA2 3538 -2886 -1308
CA4 2804 10269 -9200
CYB5R1 9299 10194 -5416
CYB5R2 8460 8847 3229
CYB5R4 8289 8151 7376
CYB5RL -10419 -6905 -7399
HBA1 8840 -859 2131
HBB 8901 -76 1800
SLC4A1 8987 -472 -681



O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes
metric value
setSize 11
pMANOVA 0.000153
p.adjustMANOVA 0.000541
s.dist 0.72
s.t0_v_pod 0.68
s.pod_crp 0.2
s.t0_crp -0.131
p.t0_v_pod 9.48e-05
p.pod_crp 0.251
p.t0_crp 0.452




Top 20 genes
Gene t0_v_pod pod_crp
CYB5R1 9299 10194
CYB5R2 8460 8847
CYB5R4 8289 8151
AQP1 7364 6140
CA4 2804 10269
CA1 9220 469

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AQP1 7364 6140 -2835
CA1 9220 469 3952
CA2 3538 -2886 -1308
CA4 2804 10269 -9200
CYB5R1 9299 10194 -5416
CYB5R2 8460 8847 3229
CYB5R4 8289 8151 7376
CYB5RL -10419 -6905 -7399
HBA1 8840 -859 2131
HBB 8901 -76 1800
SLC4A1 8987 -472 -681



Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
metric value
setSize 12
pMANOVA 0.00861
p.adjustMANOVA 0.0175
s.dist 0.715
s.t0_v_pod 0.566
s.pod_crp 0.436
s.t0_crp 0.0151
p.t0_v_pod 0.000687
p.pod_crp 0.00884
p.t0_crp 0.928




Top 20 genes
Gene t0_v_pod pod_crp
SERPINB2 9277 10648
ANXA2 8405 10984
PLAUR 8292 10654
SERPINB8 9049 7618
SERPINB6 5778 9085
S100A10 6764 6786
SERPINE2 6363 5493
PLAU 4847 2352

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ANXA2 8405 10984 6149
PLAT -1225 -1167 7394
PLAU 4847 2352 -4399
PLAUR 8292 10654 598
PLG -1938 1289 8597
S100A10 6764 6786 437
SERPINB2 9277 10648 2582
SERPINB6 5778 9085 -8463
SERPINB8 9049 7618 4184
SERPINE1 7371 -1072 -4059
SERPINE2 6363 5493 1162
SERPINF2 -6350 3505 -4553



Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
metric value
setSize 27
pMANOVA 1.58e-05
p.adjustMANOVA 7.65e-05
s.dist 0.714
s.t0_v_pod -0.537
s.pod_crp -0.472
s.t0_crp -0.00537
p.t0_v_pod 1.39e-06
p.pod_crp 2.21e-05
p.t0_crp 0.962




Top 20 genes
Gene t0_v_pod pod_crp
CD247 -11982 -9454
LCK -11482 -9442
TRAC -11130 -9287
CD3E -10952 -9335
CD3G -11173 -9082
TRBC1 -11646 -8623
TRBV12-3 -10099 -9681
CD3D -11049 -8704
TRAV19 -9587 -9353
HLA-DPB1 -11887 -7068
HLA-DQB2 -9085 -8978
TRAV29DV5 -9353 -8284
HLA-DRA -11649 -6573
HLA-DPA1 -11954 -5815
TRBV7-9 -9220 -6700
TRAV8-4 -7010 -7565
HLA-DQA2 -4652 -9364
CD4 -5228 -4848
HLA-DQA1 -11633 -1453
HLA-DRB5 -4806 -1108

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CD247 -11982 -9454 -8935
CD3D -11049 -8704 2046
CD3E -10952 -9335 5813
CD3G -11173 -9082 6756
CD4 -5228 -4848 -1251
CSK 5158 10149 -6693
HLA-DPA1 -11954 -5815 946
HLA-DPB1 -11887 -7068 -7160
HLA-DQA1 -11633 -1453 9693
HLA-DQA2 -4652 -9364 -9927
HLA-DQB1 -6199 3626 5107
HLA-DQB2 -9085 -8978 -9720
HLA-DRA -11649 -6573 2695
HLA-DRB1 -7792 1344 9366
HLA-DRB5 -4806 -1108 9092
LCK -11482 -9442 -4194
PAG1 5207 321 -4633
PTPN22 -1191 5545 9392
PTPRC 2227 7455 9473
PTPRJ 7666 9296 -4702
TRAC -11130 -9287 8688
TRAV19 -9587 -9353 -6593
TRAV29DV5 -9353 -8284 4257
TRAV8-4 -7010 -7565 10068
TRBC1 -11646 -8623 -1744
TRBV12-3 -10099 -9681 -6812
TRBV7-9 -9220 -6700 -5268



Detoxification of Reactive Oxygen Species

Detoxification of Reactive Oxygen Species
metric value
setSize 32
pMANOVA 8.18e-07
p.adjustMANOVA 5.74e-06
s.dist 0.709
s.t0_v_pod 0.561
s.pod_crp 0.431
s.t0_crp -0.0481
p.t0_v_pod 3.93e-08
p.pod_crp 2.44e-05
p.t0_crp 0.638




Top 20 genes
Gene t0_v_pod pod_crp
NCF2 9034 10855
NCF4 9111 10692
PRDX3 9206 10534
GSR 9078 10593
CYBB 8879 10038
CAT 8970 9293
P4HB 8307 9301
PRDX5 8392 8570
CYBA 6822 10446
TXN 8155 8543
TXNRD1 8062 8115
TXNRD2 7414 7792
ERO1A 8793 6446
NCF1 7224 7391
GPX1 9156 5011
PRDX1 6927 5870
SOD2 4346 8455
ATOX1 4294 6523
TXN2 4601 5184
NOX5 1165 7901

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ATOX1 4294 6523 -5464
ATP7A 688 2475 -1131
CAT 8970 9293 753
CCS 1525 2217 -9201
CYBA 6822 10446 -6535
CYBB 8879 10038 8462
CYCS -1315 -4596 7068
ERO1A 8793 6446 9877
GPX1 9156 5011 -9215
GPX2 -3430 6237 3879
GPX3 674 9213 940
GPX7 -8599 -9409 -6182
GSR 9078 10593 -1642
GSTP1 134 1763 -2320
NCF1 7224 7391 -3129
NCF2 9034 10855 2089
NCF4 9111 10692 -4957
NOX4 1105 7907 7547
NOX5 1165 7901 9420
NUDT2 2964 1821 6694
P4HB 8307 9301 -6747
PRDX1 6927 5870 9453
PRDX2 3398 -4109 2558
PRDX3 9206 10534 8582
PRDX5 8392 8570 -9501
PRDX6 8787 -816 -2927
SOD1 -4704 -5821 229
SOD2 4346 8455 458
TXN 8155 8543 4825
TXN2 4601 5184 -7333
TXNRD1 8062 8115 4242
TXNRD2 7414 7792 -6709



Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 457
pMANOVA 4.62e-105
p.adjustMANOVA 6.29e-102
s.dist 0.706
s.t0_v_pod 0.587
s.pod_crp 0.38
s.t0_crp -0.0981
p.t0_v_pod 1.73e-103
p.pod_crp 3.14e-44
p.t0_crp 0.000328




Top 20 genes
Gene t0_v_pod pod_crp
SIRPA 9348 11400
IDH1 9345 11370
DOK3 9228 11511
HK3 9225 11490
RNASE2 9344 11336
HP 9293 11371
ANPEP 9190 11472
S100A9 9353 11235
CR1 9325 11239
GNS 9200 11391
ATP6V0A1 9262 11270
CTSD 9272 11255
SIGLEC9 9223 11296
SLC11A1 9014 11536
NCSTN 9030 11510
S100A8 9341 11121
MCEMP1 9342 11112
QSOX1 9140 11347
CD63 9129 11350
CD36 9283 11160

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
A1BG 5492 1353 -9966
ABCA13 4715 -6024 -5520
ACAA1 8162 11375 -2561
ACLY 5100 9507 -3222
ACTR10 7490 4188 6836
ACTR1B -10176 -4992 -8357
ACTR2 7750 7266 8225
ADAM10 8645 9006 7606
ADAM8 5565 5930 -5020
ADGRE3 403 -1147 -5402
ADGRE5 -2508 9545 -5944
ADGRG3 8074 10276 -6490
AGA -4482 -5904 -6481
AGL -3052 -2341 5309
AGPAT2 9099 11201 -8161
ALAD 8376 10277 -8899
ALDH3B1 8521 11136 -541
ALDOA 9092 10754 -4277
ALDOC -3342 -6047 -870
ALOX5 8850 10963 897
AMPD3 8588 9281 -3891
ANO6 7924 -51 -2013
ANPEP 9190 11472 -4485
ANXA2 8405 10984 6149
AOC1 6421 -3632 -9941
AP1M1 6619 9990 -9005
AP2A2 7150 10268 -7534
APAF1 8863 5960 3785
APEH 989 4413 -8349
APRT -2695 -6293 -9129
ARG1 8615 8895 -4015
ARHGAP9 6170 10501 -5710
ARL8A 8119 9110 -7802
ARMC8 6310 184 8884
ARPC5 8544 9897 5412
ARSA 3455 9475 5057
ARSB 7459 10240 3628
ASAH1 8390 11216 7823
ATAD3B -9747 -6152 -7139
ATG7 8007 6013 5349
ATP11A 8262 10605 -3941
ATP11B 5982 4586 2812
ATP6AP2 7911 1894 6607
ATP6V0A1 9262 11270 -184
ATP6V0C 8974 10678 -1938
ATP6V1D 8894 9569 8256
ATP8A1 -11486 -9458 -3080
ATP8B4 6869 1589 203
AZU1 5442 -7180 -7085
B2M -6684 -7304 9111
B4GALT1 4248 5054 -5889
BIN2 5672 10255 -7431
BPI 6575 -7074 -6606
BRI3 8865 11091 -4309
BST1 9319 10115 1888
BST2 -7131 977 3207
C3 -11900 1885 4416
C3AR1 7890 11427 10251
C5AR1 8976 10921 -5891
C6orf120 6106 820 -2003
CAB39 8146 5846 6332
CAMP 4730 -7595 -6823
CAND1 -6331 -7166 5191
CANT1 7591 7579 -3293
CAP1 7984 8315 1306
CAPN1 8424 10080 -8421
CAT 8970 9293 753
CCT2 -8525 -9618 3713
CCT8 6464 -256 6853
CD14 8944 10372 -5065
CD177 2440 10913 -8974
CD300A -2090 10479 5751
CD33 7944 9211 -402
CD36 9283 11160 9413
CD44 8201 8363 1308
CD47 -11753 -8215 5590
CD53 7764 10096 5802
CD55 8991 10563 4478
CD58 6556 9896 10387
CD59 5783 -3188 -3930
CD63 9129 11350 -6534
CD68 8394 10795 661
CD93 9335 10634 -5548
CDA 9152 10989 -4053
CDK13 -8104 32 -5089
CEACAM1 8296 4278 -552
CEACAM3 6743 10344 10654
CEACAM6 4464 -5083 -6228
CEACAM8 4898 -6448 -4844
CEP290 -8867 -6163 10818
CFD 1971 2233 4371
CFP 7333 9805 -3105
CHI3L1 -645 -5514 -4165
CHIT1 5931 -2642 -1870
CKAP4 9210 9935 -1912
CLEC12A 4490 2545 6737
CLEC4C -11454 3076 -1232
CLEC4D 9029 9546 3993
CLEC5A 8339 5705 6152
CMTM6 7771 7571 9302
CNN2 6554 5058 -3616
COMMD3 -1344 1718 9364
COMMD9 7845 8886 4311
COPB1 7213 6115 10995
COTL1 7812 10823 1752
CPNE1 -3302 -1124 -4305
CPNE3 5796 -212 4086
CPPED1 8225 10342 930
CR1 9325 11239 78
CRACR2A -8758 -1351 -6790
CREG1 9322 7726 -5647
CRISP3 7439 -5435 -2256
CRISPLD2 8953 10866 727
CSNK2B 3930 6489 169
CST3 2193 3540 537
CSTB 6806 10741 1243
CTSA 9351 10347 -5625
CTSB 9204 11248 214
CTSC 2312 9392 5785
CTSD 9272 11255 -6838
CTSG 5056 -5642 -7628
CTSH 6273 6681 241
CTSS 8240 7109 5880
CTSZ 8825 10594 -2796
CXCL1 5749 35 -7929
CXCR1 6768 5942 -4296
CXCR2 5785 1478 -4192
CYB5R3 8753 9668 -8623
CYBA 6822 10446 -6535
CYBB 8879 10038 8462
CYFIP1 9108 10929 1675
CYSTM1 8924 9339 1556
DBNL 7633 9423 -9565
DDOST 6831 7376 -7998
DDX3X 6524 -1636 -394
DEFA1 5979 -1326 -7916
DEFA4 5976 -3207 -4350
DEGS1 6085 -377 -3072
DERA 8364 9539 9162
DGAT1 5245 5383 -7475
DIAPH1 -848 2340 -1599
DNAJC13 8133 9506 9974
DNAJC3 8302 8189 7460
DNAJC5 8537 9755 -6677
DNASE1L1 8491 11486 -1493
DOCK2 7609 10071 -1434
DOK3 9228 11511 -1549
DPP7 -4437 -4122 -9813
DSC1 -6691 -9262 -1990
DSN1 -10430 -3359 6274
DSP -1779 2585 -8705
DYNC1H1 -7417 -1029 -6456
DYNC1LI1 6841 7785 8760
DYNLL1 5873 3157 -957
DYNLT1 4406 7399 7711
EEF1A1 -4918 -9346 -7605
EEF2 304 -7032 -9881
ELANE 7212 -5995 -6381
ENPP4 -9264 -5181 3880
EPX -4683 -1900 1003
ERP44 6807 2930 9188
FABP5 5940 6410 3203
FAF2 5487 4092 607
FCAR 8958 8893 -3605
FCER1G 8004 11307 6688
FCGR2A 8699 10192 5608
FCGR3B 4269 -2607 -4037
FCN1 8960 9070 -663
FGL2 669 -3982 8732
FGR 8344 11409 -3712
FOLR3 7339 9195 -8003
FPR1 9137 11128 -1439
FPR2 8942 10615 8911
FRK -24 4203 6313
FRMPD3 -11117 -6990 -2652
FTH1 4846 6298 -896
FTL 8523 10185 1590
FUCA1 7298 6432 -1662
FUCA2 8173 6437 2892
GAA 7846 8164 -4427
GALNS 6998 9617 -5269
GCA 9275 10574 8458
GDI2 7175 5201 7848
GGH 6119 2669 7384
GHDC 4117 3141 -8050
GLA 8430 10876 923
GLB1 8581 10666 2258
GLIPR1 7623 5719 9923
GM2A 8906 11045 7136
GMFG 8129 9415 685
GNS 9200 11391 3599
GOLGA7 4015 -4727 3414
GPI 6198 4623 -5172
GPR84 8980 10036 1662
GRN 9150 10896 -1134
GSDMD 1942 4244 -5496
GSN 8605 9745 -6892
GSTP1 134 1763 -2320
GUSB 7607 11238 -5640
GYG1 8861 10131 -768
HBB 8901 -76 1800
HEBP2 8266 5620 -4336
HEXB 8631 6847 3887
HGSNAT 1854 -3565 -171
HK3 9225 11490 516
HLA-A -2510 -5419 -8750
HLA-B 643 2292 -1943
HLA-C 1010 3087 142
HLA-H -3771 -1299 -9269
HMGB1 -251 -7642 4980
HMOX2 -11464 -9169 -8180
HP 9293 11371 -1099
HPSE 8342 10129 -2829
HRNR -7096 -3485 -3932
HSP90AA1 1316 -5048 8114
HSP90AB1 -6629 -9109 3150
HSPA1A 7946 6632 -7658
HSPA1B 6382 4388 4023
HSPA6 6426 9769 -4167
HSPA8 -10578 -9123 450
HUWE1 -7700 -1644 -5495
HVCN1 4856 3746 -2268
IDH1 9345 11370 9398
IGF2R 7044 9926 -8671
ILF2 -1939 -4024 6633
IMPDH1 9136 11141 -3002
IMPDH2 -9588 -9804 -8220
IQGAP1 8024 8880 -22
IQGAP2 6509 8781 5493
IST1 5786 7557 6588
ITGAL -10503 2853 -4573
ITGAM 9238 11094 -6412
ITGAV 6022 8016 5164
ITGAX 7227 11380 -4395
ITGB2 8792 10785 -8996
JUP -5176 -2038 -86
KCMF1 7749 4009 3407
KCNAB2 -101 7305 -9812
KPNB1 2414 -106 6972
KRT1 4492 -7266 -6517
LAIR1 7078 11275 -2151
LAMP1 7515 8498 -8622
LAMP2 8640 7271 7539
LAMTOR1 9251 9713 -9592
LAMTOR2 7454 9183 -8579
LAMTOR3 7461 2039 8800
LCN2 7639 -4880 -5370
LGALS3 8608 9166 230
LILRB2 7933 11537 1613
LILRB3 8723 10376 -8473
LPCAT1 -7171 5166 -6116
LRG1 8532 9402 -7556
LRRC7 -1927 -736 -259
LTA4H 9104 10873 5772
LTF 6220 -6500 -6805
LYZ 7107 -780 712
MAGT1 2594 71 5712
MAN2B1 6781 6633 -5993
MANBA 7276 7952 9758
MAPK1 7381 10667 -1770
MAPK14 8951 10298 4000
MCEMP1 9342 11112 -5793
METTL7A 6820 7311 8416
MGAM 8897 9621 -9363
MGST1 9321 9918 4962
MIF -3748 -6781 -8075
MLEC 2308 -3597 -3145
MME 909 -1728 -4970
MMP25 8377 10474 -2299
MMP8 9075 335 -5785
MMP9 1677 10160 -9943
MNDA 9119 9202 8786
MOSPD2 8122 11282 10954
MPO 7325 -7916 -8368
MS4A3 2347 -5944 6699
MVP 6950 9031 -7677
NAPRT 7301 10471 565
NBEAL2 6982 10524 -5465
NCKAP1L 7557 11206 1696
NCSTN 9030 11510 3979
NDUFC2 6011 6708 -5860
NEU1 8877 11207 1713
NFAM1 8933 10997 -4892
NFASC 859 6416 4430
NFKB1 6191 -2146 1214
NHLRC3 1266 6966 9935
NIT2 -11340 -7590 6402
NME2 1837 -394 3562
NPC2 5393 7468 6268
NRAS 5302 1813 9977
OLFM4 8580 -31 -8934
OLR1 2469 -6082 -1197
ORM1 7849 3440 -9868
ORM2 -2501 4509 -6579
ORMDL3 -9667 -8120 -7124
OSCAR 8915 11520 4280
OSTF1 7314 6525 2590
P2RX1 8303 11531 5876
PA2G4 -3797 -5507 4964
PADI2 9100 10696 -8272
PAFAH1B2 6842 2339 6018
PDAP1 5831 9593 -9354
PDXK 8494 7567 -2595
PECAM1 7735 11120 5659
PFKL -3189 1182 -9482
PGAM1 9274 11111 -2886
PGLYRP1 7789 1980 -9321
PGM1 5767 4697 -7900
PGM2 9185 9410 3358
PGRMC1 7677 -3729 -2147
PIGR -484 6471 4271
PKM 9231 10377 -2608
PLAC8 8319 11082 -3448
PLAU 4847 2352 -4399
PLAUR 8292 10654 598
PLD1 9148 10350 6144
PLEKHO2 7935 10786 1828
PNP 8287 8496 2099
PPBP 5961 -5680 -6890
PPIA -6535 -4528 -557
PPIE -8695 -5029 5118
PRCP 8088 7480 7688
PRDX4 -144 5888 6406
PRDX6 8787 -816 -2927
PRKCD 8856 11308 806
PRTN3 6667 -6330 -9828
PSAP 7040 9870 1324
PSEN1 7839 10691 5400
PSMA2 5278 -2014 3859
PSMA5 -5853 -6322 7981
PSMB1 3345 -1943 -880
PSMB7 8350 7844 -5414
PSMC2 2579 4416 7925
PSMC3 1963 2166 -5940
PSMD1 7134 6286 7596
PSMD11 6145 6978 10268
PSMD12 6467 5654 11287
PSMD13 5869 3735 -2361
PSMD14 2592 225 8785
PSMD2 7300 5486 -7349
PSMD3 4569 4137 -9803
PSMD6 7726 8633 4780
PSMD7 5884 1537 9328
PTAFR 9195 10579 -6397
PTGES2 -6690 -3301 -9202
PTPN6 6014 11061 -2766
PTPRB -7344 -1883 -8074
PTPRC 2227 7455 9473
PTPRJ 7666 9296 -4702
PTPRN2 5122 -2349 -3483
PTX3 5722 -995 7805
PYCARD 8497 10906 -3514
PYGB 486 -3041 -7463
PYGL 9257 10610 -3750
QPCT 9168 10241 2637
QSOX1 9140 11347 -5224
RAB10 8776 10722 5688
RAB14 6991 2915 9597
RAB18 7683 4326 11226
RAB24 5293 10429 4954
RAB27A 8279 7836 8565
RAB31 9196 9894 4968
RAB37 -11438 -6247 -3878
RAB3A 8006 1221 -9658
RAB3D 9051 10017 1582
RAB44 567 -5800 -1505
RAB4B 3111 10066 -6147
RAB5B 6599 4884 -1226
RAB5C 8513 10039 -6403
RAB6A 8020 7487 7945
RAB7A 8598 9167 2133
RAB9B -6329 -4634 2215
RAC1 8647 10726 9288
RAP1A 7198 6943 11289
RAP1B 3179 5307 7206
RAP2B -765 1001 -662
RAP2C 4551 4998 7679
RETN 8848 10349 5200
RHOA 8188 8640 7321
RHOF -11981 -8988 -7491
RHOG 8352 10463 -1690
RNASE2 9344 11336 10281
RNASE3 7359 1010 3204
RNASET2 5844 8694 -2775
ROCK1 7377 6942 10322
S100A11 8796 10890 3761
S100A12 9352 10889 3333
S100A8 9341 11121 2853
S100A9 9353 11235 226
S100P 8199 9316 -7931
SCAMP1 1855 -7626 6821
SDCBP 9153 9404 8662
SELL 8762 8713 625
SERPINA1 9013 11480 6681
SERPINB1 9273 10752 2537
SERPINB10 8783 3814 -4112
SERPINB6 5778 9085 -8463
SIGLEC14 5028 129 -3738
SIGLEC5 8033 6183 -793
SIGLEC9 9223 11296 -2592
SIRPA 9348 11400 -1174
SIRPB1 7723 6957 -7936
SLC11A1 9014 11536 -778
SLC15A4 3690 9552 -915
SLC27A2 -3718 -7230 9199
SLC2A3 8869 9612 -6003
SLC2A5 2031 -3120 5048
SLC44A2 2678 34 -7769
SLCO4C1 3185 3073 2134
SLPI 5237 -947 -2393
SNAP23 8487 4303 6932
SNAP29 6302 8481 -9182
SPTAN1 -11074 -9473 -8917
SRP14 6234 4952 6220
STBD1 5477 -453 2023
STING1 4736 -467 -2958
STK10 -3780 7207 -7919
STK11IP 3554 10226 -8927
STOM 6613 3408 836
SURF4 6954 5080 -5301
SVIP 2022 -7342 5254
SYNGR1 -4479 -2143 -6560
TARM1 5246 4590 2177
TBC1D10C -11505 -7229 -9560
TCIRG1 7082 11503 -5720
TCN1 6098 -6179 4352
TICAM2 6249 5514 9918
TIMP2 9297 11124 -5506
TLR2 8950 10582 9812
TMBIM1 8229 9127 -7190
TMC6 -10267 -4664 -7552
TMEM179B 443 983 -423
TMEM30A 7913 4486 9463
TMEM63A -8824 -7322 -1667
TNFAIP6 8594 11144 2592
TNFRSF1B 5964 10836 -3052
TOLLIP 8432 7708 -7962
TOM1 9044 10733 -8405
TRAPPC1 7688 8766 -4414
TRPM2 8949 10980 -6192
TSPAN14 6870 10420 -4594
TUBB -6718 -5253 -854
TUBB4B 7133 6509 -5525
TXNDC5 391 -4174 5239
TYROBP 7427 10576 -4257
UBR4 -2044 2816 -3205
UNC13D 7492 11075 -6891
VAMP8 5157 4210 -6012
VAPA 8881 8035 5255
VAT1 9118 10856 -8461
VCL 7218 1206 -2715
VCP 6789 4231 -5183
VNN1 8939 11139 8141
VPS35L 6034 9056 4608
XRCC5 5322 -2461 4335
XRCC6 -4326 -7728 1717
YPEL5 6593 6479 4396



ROS and RNS production in phagocytes

ROS and RNS production in phagocytes
metric value
setSize 31
pMANOVA 1.98e-07
p.adjustMANOVA 1.5e-06
s.dist 0.704
s.t0_v_pod 0.597
s.pod_crp 0.367
s.t0_crp -0.0586
p.t0_v_pod 8.47e-09
p.pod_crp 0.000398
p.t0_crp 0.573




Top 20 genes
Gene t0_v_pod pod_crp
ATP6V0A1 9262 11270
SLC11A1 9014 11536
ATP6V0D1 9088 11089
NCF2 9034 10855
NCF4 9111 10692
ATP6V0C 8974 10678
CYBB 8879 10038
ATP6V0B 8458 10337
ATP6V1B2 8904 9564
ATP6V1D 8894 9569
TCIRG1 7082 11503
ATP6V1A 9144 8379
ATP6V1C1 8400 8697
CYBA 6822 10446
ATP6V0E1 8456 8200
ATP6V1E1 7912 7496
NCF1 7224 7391
ATP6V1H 7939 4992
ATP6V1F 5802 5090
RAC2 5104 5027

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ATP6V0A1 9262 11270 -184
ATP6V0A2 -11850 -4901 2656
ATP6V0B 8458 10337 -6528
ATP6V0C 8974 10678 -1938
ATP6V0D1 9088 11089 -1722
ATP6V0E1 8456 8200 -226
ATP6V0E2 -11202 -8309 1787
ATP6V1A 9144 8379 5839
ATP6V1B2 8904 9564 3425
ATP6V1C1 8400 8697 8360
ATP6V1C2 -2175 -2046 -2521
ATP6V1D 8894 9569 8256
ATP6V1E1 7912 7496 8195
ATP6V1E2 5657 -5806 -7499
ATP6V1F 5802 5090 -6651
ATP6V1G1 3892 -4430 794
ATP6V1G2 -9197 -8007 -1854
ATP6V1H 7939 4992 5368
CYBA 6822 10446 -6535
CYBB 8879 10038 8462
HVCN1 4856 3746 -2268
LPO 6414 2023 5426
MPO 7325 -7916 -8368
NCF1 7224 7391 -3129
NCF2 9034 10855 2089
NCF4 9111 10692 -4957
NOS1 1355 7583 6535
NOS3 -2018 -6797 2341
RAC2 5104 5027 -8160
SLC11A1 9014 11536 -778
TCIRG1 7082 11503 -5720



Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
metric value
setSize 135
pMANOVA 1.83e-37
p.adjustMANOVA 9.58e-36
s.dist 0.703
s.t0_v_pod -0.225
s.pod_crp -0.544
s.t0_crp -0.384
p.t0_v_pod 6.45e-06
p.pod_crp 8.94e-28
p.t0_crp 1.21e-14




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AAAS -8101 625 -1546
DNAJC3 8302 8189 7460
FAU -359 -1018 -9018
GRSF1 5110 -3098 3896
GTF2F1 4893 5437 -9039
GTF2F2 5371 5207 5137
HSP90AA1 1316 -5048 8114
IPO5 -10252 -9795 -1839
NDC1 -11812 -9774 -73
NUP107 -10085 -8758 7683
NUP133 -7491 -5635 5219
NUP153 -6108 -4400 3509
NUP155 -9900 -7591 2977
NUP160 -10219 -8656 3162
NUP188 -11270 -7253 -5615
NUP205 -10971 -7010 3379
NUP210 -10384 -4340 -8792
NUP214 7800 9971 2007
NUP35 -10272 -9583 8608
NUP37 3049 -1412 3817
NUP42 -5378 -2693 10509
NUP43 -9198 -7750 10186
NUP50 4476 -1230 6822
NUP54 -8189 -5304 11136
NUP58 8674 7535 6567
NUP62 763 394 -2984
NUP85 -2971 -1702 6335
NUP88 -11046 -9387 4338
NUP93 -11266 -3136 2920
NUP98 3075 175 2062
PARP1 -11409 -9090 -4667
POLR2A -3010 6319 -6014
POLR2B -2462 -5075 7311
POLR2C 1603 -2543 -2871
POLR2D -3902 -8118 4726
POLR2E 7450 5182 -8728
POLR2F 4555 5678 -8849
POLR2G 3477 5635 -7724
POLR2H -2867 -3580 -4558
POLR2I 394 -1586 -8884
POLR2J 6580 7886 -5760
POLR2K -1750 -3871 9561
POLR2L 5244 3421 -9948
POM121 -8013 -2273 -8608
POM121C -6940 -6034 -9057
RAE1 5105 4986 5899
RANBP2 -814 -3082 5483
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SEC13 5675 6716 -3023
SEH1L -5868 -8749 9484
TPR -6786 -4096 4769
UBA52 1112 -1425 -7104



SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
metric value
setSize 111
pMANOVA 5.6e-38
p.adjustMANOVA 3.05e-36
s.dist 0.702
s.t0_v_pod -0.134
s.pod_crp -0.559
s.t0_crp -0.404
p.t0_v_pod 0.0148
p.pod_crp 2.4e-24
p.t0_crp 1.86e-13




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
DDOST 6831 7376 -7998
FAU -359 -1018 -9018
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPN1 7902 4000 -6048
RPN2 7035 7029 4420
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SEC11A 7799 7093 1007
SEC11C -8699 -5267 10431
SEC61A1 6361 3940 -950
SEC61A2 -10455 -3235 9212
SEC61B 6910 4481 -2532
SEC61G 4656 -2306 10727
SPCS1 2996 -1989 4208
SPCS2 3184 -2426 10641
SPCS3 4326 -1801 10410
SRP14 6234 4952 6220
SRP19 4236 -478 10627
SRP54 6501 6398 11317
SRP68 2001 -2539 4255
SRP72 -1470 -4790 6023
SRP9 4400 -4365 10477
SRPRA 4999 5439 -5685
SRPRB -9099 -8472 6212
SSR1 6498 -2621 7135
SSR2 2796 -2339 1929
SSR3 5856 -657 7929
SSR4 3109 1947 -6051
TRAM1 -4486 -7869 9372
UBA52 1112 -1425 -7104



Platelet sensitization by LDL

Platelet sensitization by LDL
metric value
setSize 16
pMANOVA 0.00192
p.adjustMANOVA 0.00472
s.dist 0.697
s.t0_v_pod 0.552
s.pod_crp 0.418
s.t0_crp 0.0793
p.t0_v_pod 0.000131
p.pod_crp 0.00383
p.t0_crp 0.583




Top 20 genes
Gene t0_v_pod pod_crp
FGR 8344 11409
MAPK14 8951 10298
PLA2G4A 9025 9798
PECAM1 7735 11120
PPP2R5B 6679 10409
PTPN6 6014 11061
LRP8 4522 10156
PPP2R5A 5821 7421
PPP2CB 7596 5321
PPP2CA 8104 4832
PPP2R1A 4542 4551
PTPN11 5253 2833
PPP2R5D 2405 2534

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
FGR 8344 11409 -3712
LRP8 4522 10156 -4090
MAPK14 8951 10298 4000
PECAM1 7735 11120 5659
PLA2G4A 9025 9798 9511
PPP2CA 8104 4832 5474
PPP2CB 7596 5321 8298
PPP2R1A 4542 4551 -7355
PPP2R1B -241 -2878 3499
PPP2R5A 5821 7421 4928
PPP2R5B 6679 10409 -2611
PPP2R5C -10916 -7637 3918
PPP2R5D 2405 2534 -2384
PPP2R5E -675 -6243 2034
PTPN11 5253 2833 -599
PTPN6 6014 11061 -2766



Trafficking of GluR2-containing AMPA receptors

Trafficking of GluR2-containing AMPA receptors
metric value
setSize 12
pMANOVA 0.00172
p.adjustMANOVA 0.00433
s.dist 0.695
s.t0_v_pod 0.469
s.pod_crp 0.278
s.t0_crp -0.431
p.t0_v_pod 0.00491
p.pod_crp 0.095
p.t0_crp 0.00968




Top 20 genes
Gene t0_v_pod t0_crp
AP2M1 8486 -8627
PRKCB 6993 -7987
AP2A2 7150 -7534
AP2A1 6737 -6569
PICK1 3562 -8925
AP2S1 7903 -3704
TSPAN7 6381 -2373
PRKCA 1123 -5853

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AP2A1 6737 11502 -6569
AP2A2 7150 10268 -7534
AP2B1 -2641 -3659 -3248
AP2M1 8486 7237 -8627
AP2S1 7903 9372 -3704
GRIA4 -97 5796 6158
GRIP1 -10075 -9327 -1211
NSF 8683 9716 2271
PICK1 3562 5147 -8925
PRKCA 1123 -5628 -5853
PRKCB 6993 7023 -7987
TSPAN7 6381 -1548 -2373



Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade
metric value
setSize 23
pMANOVA 0.000143
p.adjustMANOVA 0.000512
s.dist 0.694
s.t0_v_pod 0.534
s.pod_crp 0.441
s.t0_crp 0.0319
p.t0_v_pod 9.12e-06
p.pod_crp 0.000247
p.t0_crp 0.791




Top 20 genes
Gene t0_v_pod pod_crp
CD36 9283 11160
TLR5 9045 10806
TLR2 8950 10582
CD14 8944 10372
MYD88 8009 11413
LY96 8649 9854
TLR4 8864 9225
BTK 7100 11184
TLR1 8782 8637
TLR6 8694 7538
TICAM1 6221 9502
CHUK 7844 7098
IKBKG 5315 8787
UNC93B1 4129 10825
TIRAP 5571 6784
NFKBIA 6712 3910

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BTK 7100 11184 8838
CD14 8944 10372 -5065
CD36 9283 11160 9413
CHUK 7844 7098 7094
IKBKB -5208 5101 -4279
IKBKG 5315 8787 -7863
LY96 8649 9854 7645
MYD88 8009 11413 3934
NFKB1 6191 -2146 1214
NFKB2 -1150 1265 -300
NFKBIA 6712 3910 -4500
RELA -1770 -2540 -9307
TICAM1 6221 9502 -881
TIRAP 5571 6784 -3461
TLR1 8782 8637 7301
TLR10 -2886 -6753 -1228
TLR2 8950 10582 9812
TLR3 -11172 -9451 1584
TLR4 8864 9225 1420
TLR5 9045 10806 4896
TLR6 8694 7538 2941
TRAF3 -5390 -5162 -6877
UNC93B1 4129 10825 250



Diseases of Immune System

Diseases of Immune System
metric value
setSize 23
pMANOVA 0.000143
p.adjustMANOVA 0.000512
s.dist 0.694
s.t0_v_pod 0.534
s.pod_crp 0.441
s.t0_crp 0.0319
p.t0_v_pod 9.12e-06
p.pod_crp 0.000247
p.t0_crp 0.791




Top 20 genes
Gene t0_v_pod pod_crp
CD36 9283 11160
TLR5 9045 10806
TLR2 8950 10582
CD14 8944 10372
MYD88 8009 11413
LY96 8649 9854
TLR4 8864 9225
BTK 7100 11184
TLR1 8782 8637
TLR6 8694 7538
TICAM1 6221 9502
CHUK 7844 7098
IKBKG 5315 8787
UNC93B1 4129 10825
TIRAP 5571 6784
NFKBIA 6712 3910

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BTK 7100 11184 8838
CD14 8944 10372 -5065
CD36 9283 11160 9413
CHUK 7844 7098 7094
IKBKB -5208 5101 -4279
IKBKG 5315 8787 -7863
LY96 8649 9854 7645
MYD88 8009 11413 3934
NFKB1 6191 -2146 1214
NFKB2 -1150 1265 -300
NFKBIA 6712 3910 -4500
RELA -1770 -2540 -9307
TICAM1 6221 9502 -881
TIRAP 5571 6784 -3461
TLR1 8782 8637 7301
TLR10 -2886 -6753 -1228
TLR2 8950 10582 9812
TLR3 -11172 -9451 1584
TLR4 8864 9225 1420
TLR5 9045 10806 4896
TLR6 8694 7538 2941
TRAF3 -5390 -5162 -6877
UNC93B1 4129 10825 250



PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
metric value
setSize 13
pMANOVA 0.00602
p.adjustMANOVA 0.0127
s.dist 0.693
s.t0_v_pod 0.555
s.pod_crp 0.395
s.t0_crp 0.124
p.t0_v_pod 0.000528
p.pod_crp 0.0136
p.t0_crp 0.44




Top 20 genes
Gene t0_v_pod pod_crp
RAC1 8647 10726
CRK 8756 9243
RHOA 8188 8640
DOCK1 7206 8430
PTK6 5877 8863
PXN 6144 8429
ELMO2 4353 9704
RASA1 2093 6650
KRAS 3668 3086
NRAS 5302 1813

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ARHGAP35 -3266 -5145 -7271
CRK 8756 9243 8031
DOCK1 7206 8430 -6510
ELMO1 6172 -1400 -4598
ELMO2 4353 9704 5888
HRAS -3288 -3089 -7583
KRAS 3668 3086 11151
NRAS 5302 1813 9977
PTK6 5877 8863 -2030
PXN 6144 8429 -7995
RAC1 8647 10726 9288
RASA1 2093 6650 9826
RHOA 8188 8640 7321



rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
metric value
setSize 59
pMANOVA 7.21e-12
p.adjustMANOVA 1.21e-10
s.dist 0.691
s.t0_v_pod -0.397
s.pod_crp -0.556
s.t0_crp -0.0986
p.t0_v_pod 1.32e-07
p.pod_crp 1.39e-13
p.t0_crp 0.19




Top 20 genes
Gene pod_crp t0_v_pod
DKC1 -9791 -11282
NAT10 -9283 -11593
UTP4 -9295 -11142
BMS1 -9121 -11315
NOP14 -9676 -10522
FBL -9628 -9855
NOP56 -8304 -11395
NOL11 -9311 -10134
NOP58 -9323 -9623
PDCD11 -7938 -11166
WDR75 -9170 -9593
THUMPD1 -9268 -9477
IMP4 -8191 -10629
DDX47 -7920 -10949
UTP15 -8238 -10264
RRP9 -8079 -9748
WDR46 -6936 -10623
HEATR1 -7318 -10009
NOL6 -6904 -10564
DIMT1 -9187 -7711

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BMS1 -11315 -9121 -2978
DCAF13 -5386 -4214 -1334
DDX47 -10949 -7920 10936
DDX49 4816 4154 -9489
DDX52 448 1493 11328
DHX37 -7983 -5722 -6991
DIMT1 -7711 -9187 9761
DKC1 -11282 -9791 -2099
EMG1 -9856 -6694 4341
FBL -9855 -9628 -9879
FCF1 4428 -2984 7360
GAR1 -6703 -6656 -530
HEATR1 -10009 -7318 1473
IMP3 -9143 -6956 -3753
IMP4 -10629 -8191 -5663
KRR1 -8329 -6392 7558
MPHOSPH10 -7519 -6550 11244
NAT10 -11593 -9283 -5917
NHP2 -3373 -5708 -7073
NOC4L -5298 7372 -3269
NOL11 -10134 -9311 9550
NOL6 -10564 -6904 -9301
NOP10 8200 10614 -3974
NOP14 -10522 -9676 -4648
NOP2 -9624 -6235 -7727
NOP56 -11395 -8304 -926
NOP58 -9623 -9323 9270
PDCD11 -11166 -7938 -6311
PNO1 -6627 -7464 6858
PWP2 -1190 -7158 -7255
RCL1 -751 -7719 -4623
RPS14 -5278 -8295 -7890
RPS2 -4354 -9592 -9910
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS9 5358 2375 -7391
RRP36 -1645 510 -1316
RRP7A -2734 -4541 -659
RRP9 -9748 -8079 -9693
SNORD3A -2477 11233 9893
SNU13 -6637 -7945 -4150
TBL3 -3341 55 -8145
THUMPD1 -9477 -9268 8192
TRMT112 732 -366 -8610
TSR3 3808 -354 -8970
UTP11 4582 1261 8086
UTP14A -1788 -3133 4462
UTP14C -2032 -1616 5210
UTP15 -10264 -8238 10459
UTP18 5055 3705 3978
UTP20 -10191 -6857 6223
UTP3 -2829 -1448 -1947
UTP4 -11142 -9295 -1037
UTP6 -4362 -5407 9675
WDR3 -6394 -7931 -33
WDR36 -3825 -5814 6003
WDR43 -7419 -8808 3001
WDR46 -10623 -6936 -9396
WDR75 -9593 -9170 7264



Insulin receptor recycling

Insulin receptor recycling
metric value
setSize 21
pMANOVA 0.000116
p.adjustMANOVA 0.000431
s.dist 0.689
s.t0_v_pod 0.568
s.pod_crp 0.383
s.t0_crp -0.0651
p.t0_v_pod 6.47e-06
p.pod_crp 0.00236
p.t0_crp 0.606




Top 20 genes
Gene t0_v_pod pod_crp
ATP6V0A1 9262 11270
ATP6V0D1 9088 11089
ATP6V0C 8974 10678
ATP6AP1 8032 11319
ATP6V0B 8458 10337
ATP6V1B2 8904 9564
ATP6V1D 8894 9569
TCIRG1 7082 11503
ATP6V1A 9144 8379
INSR 8152 9155
ATP6V1C1 8400 8697
ATP6V0E1 8456 8200
ATP6V1E1 7912 7496
ATP6V1H 7939 4992
ATP6V1F 5802 5090

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All member genes
t0_v_pod pod_crp t0_crp
ATP6AP1 8032 11319 -7483
ATP6V0A1 9262 11270 -184
ATP6V0A2 -11850 -4901 2656
ATP6V0B 8458 10337 -6528
ATP6V0C 8974 10678 -1938
ATP6V0D1 9088 11089 -1722
ATP6V0E1 8456 8200 -226
ATP6V0E2 -11202 -8309 1787
ATP6V1A 9144 8379 5839
ATP6V1B2 8904 9564 3425
ATP6V1C1 8400 8697 8360
ATP6V1C2 -2175 -2046 -2521
ATP6V1D 8894 9569 8256
ATP6V1E1 7912 7496 8195
ATP6V1E2 5657 -5806 -7499
ATP6V1F 5802 5090 -6651
ATP6V1G1 3892 -4430 794
ATP6V1G2 -9197 -8007 -1854
ATP6V1H 7939 4992 5368
INSR 8152 9155 -3492
TCIRG1 7082 11503 -5720



Heme degradation

Heme degradation
metric value
setSize 10
pMANOVA 0.0173
p.adjustMANOVA 0.0323
s.dist 0.687
s.t0_v_pod 0.401
s.pod_crp 0.535
s.t0_crp -0.156
p.t0_v_pod 0.028
p.pod_crp 0.00341
p.t0_crp 0.392




Top 20 genes
Gene pod_crp t0_v_pod
HMOX1 11322 8148
SLCO2B1 10404 8317
GUSB 11238 7607
BLVRB 8056 9219
BLVRA 10555 5690
ALB 9318 3634
ABCC1 7725 570

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ABCC1 570 7725 -2091
ABCC2 -2037 5017 -497
ABCG2 -77 1178 -3387
ALB 3634 9318 6958
BLVRA 5690 10555 7145
BLVRB 9219 8056 -6449
GUSB 7607 11238 -5640
HMOX1 8148 11322 -5911
HMOX2 -11464 -9169 -8180
SLCO2B1 8317 10404 7741



p130Cas linkage to MAPK signaling for integrins

p130Cas linkage to MAPK signaling for integrins
metric value
setSize 11
pMANOVA 0.000141
p.adjustMANOVA 0.000509
s.dist 0.686
s.t0_v_pod 0.666
s.pod_crp 0.159
s.t0_crp -0.0404
p.t0_v_pod 0.000132
p.pod_crp 0.36
p.t0_crp 0.817




Top 20 genes
Gene t0_v_pod pod_crp
APBB1IP 8600 9624
CRK 8756 9243
TLN1 8386 8793
RAP1A 7198 6943
RAP1B 3179 5307
ITGA2B 8744 1914

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
APBB1IP 8600 9624 5781
CRK 8756 9243 8031
FN1 8154 -1733 4890
ITGA2B 8744 1914 -6113
ITGB3 8161 -2845 -6419
PTK2 4418 -3305 -1920
RAP1A 7198 6943 11289
RAP1B 3179 5307 7206
SRC -8520 -5490 -4085
TLN1 8386 8793 -7844
VWF 6550 -369 -8508



rRNA processing

rRNA processing
metric value
setSize 217
pMANOVA 3.11e-50
p.adjustMANOVA 6.05e-48
s.dist 0.685
s.t0_v_pod -0.289
s.pod_crp -0.544
s.t0_crp -0.299
p.t0_v_pod 2.16e-13
p.pod_crp 1.51e-43
p.t0_crp 3.13e-14




Top 20 genes
Gene pod_crp t0_crp
FBL -9628 -9879
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RRP9 -8079 -9693
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
EXOSC2 -8130 -8291
EXOSC5 -8229 -8152
RPL37 -6620 -9973

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
BMS1 -11315 -9121 -2978
BOP1 -5039 -5105 -9461
BYSL -4316 -5824 -5291
C1D 3484 530 10834
CSNK1D 2374 7369 -9414
CSNK1E -9964 -7485 -8511
DCAF13 -5386 -4214 -1334
DDX21 3087 -3715 7759
DDX47 -10949 -7920 10936
DDX49 4816 4154 -9489
DDX52 448 1493 11328
DHX37 -7983 -5722 -6991
DIMT1 -7711 -9187 9761
DIS3 -4187 -3885 11031
DKC1 -11282 -9791 -2099
EBNA1BP2 -3970 -6823 -1321
ELAC2 -11406 -3655 -2225
EMG1 -9856 -6694 4341
ERI1 5474 1977 9721
EXOSC1 -979 2548 5536
EXOSC10 -11028 -5076 4728
EXOSC2 -10724 -8130 -8291
EXOSC3 503 280 2174
EXOSC4 7485 8780 -6432
EXOSC5 -4428 -8229 -8152
EXOSC6 -9514 -7940 -3133
EXOSC7 -10290 -6545 -9416
EXOSC8 -11104 -7863 7938
EXOSC9 -9917 -7435 10177
FAU -359 -1018 -9018
FBL -9855 -9628 -9879
FCF1 4428 -2984 7360
FTSJ3 -3900 3485 -5754
GAR1 -6703 -6656 -530
GNL3 -8199 -9337 5789
HEATR1 -10009 -7318 1473
HSD17B10 4141 6396 -2742
IMP3 -9143 -6956 -3753
IMP4 -10629 -8191 -5663
ISG20L2 3737 -42 1389
KRR1 -8329 -6392 7558
LAS1L -11905 -8458 -7799
LTV1 -4162 -4559 7450
MPHOSPH10 -7519 -6550 11244
MPHOSPH6 2168 -2313 5028
MRM1 -10179 -7139 -5593
MRM2 1450 -3163 -1074
MRM3 -7261 -5459 -1972
MT-ATP6 -2053 36 -9285
MT-ATP8 -2987 1930 -9997
MT-CO1 678 506 -664
MT-CO2 48 727 -5477
MT-CO3 40 -4216 -8386
MT-CYB -2209 -2076 -6754
MT-ND1 -3510 -5813 -6341
MT-ND2 -6337 -6687 -4767
MT-ND3 -3542 -2943 -8163
MT-ND4 833 5788 3171
MT-ND4L -1983 3127 -8767
MT-ND5 -2122 -3161 -5938
MT-RNR1 -298 -6444 -3154
MT-RNR2 2099 -138 -3495
MT-TF -2683 1005 -8011
MT-TL1 -2901 4971 -3694
MT-TV -3544 4473 -8156
MTERF4 -10547 -9447 -5484
MTREX -2574 -4700 10249
NAT10 -11593 -9283 -5917
NCL -8953 -9124 -4545
NHP2 -3373 -5708 -7073
NIP7 -5682 -8082 5054
NOB1 -9986 -9210 -6132
NOC4L -5298 7372 -3269
NOL11 -10134 -9311 9550
NOL12 4887 5706 -708
NOL6 -10564 -6904 -9301
NOL9 -9891 -7152 4295
NOP10 8200 10614 -3974
NOP14 -10522 -9676 -4648
NOP2 -9624 -6235 -7727
NOP56 -11395 -8304 -926
NOP58 -9623 -9323 9270
NSUN4 -4645 4095 4554
PDCD11 -11166 -7938 -6311
PELP1 -10584 -7287 -1544
PES1 -1993 -5454 -8799
PNO1 -6627 -7464 6858
PRORP 3361 -3583 5847
PWP2 -1190 -7158 -7255
RBM28 -11316 -5771 -5592
RCL1 -751 -7719 -4623
RIOK1 -3702 -3302 6967
RIOK2 927 -8363 9267
RIOK3 8621 2731 9110
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPP14 2981 -2410 8611
RPP21 -5178 -197 -7267
RPP25 -7963 -7582 -5681
RPP30 -7818 -7132 9074
RPP38 -6833 -6494 8801
RPP40 -4680 -9576 3718
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
RRP1 -3003 872 -2135
RRP36 -1645 510 -1316
RRP7A -2734 -4541 -659
RRP9 -9748 -8079 -9693
SENP3 2970 4193 -2573
SNORD3A -2477 11233 9893
SNU13 -6637 -7945 -4150
TBL3 -3341 55 -8145
TEX10 -9440 -8701 9112
TFB1M -10994 -4570 6526
THUMPD1 -9477 -9268 8192
TRMT10C -4336 -8228 10330
TRMT112 732 -366 -8610
TSR1 -9409 -9680 -814
TSR3 3808 -354 -8970
UBA52 1112 -1425 -7104
UTP11 4582 1261 8086
UTP14A -1788 -3133 4462
UTP14C -2032 -1616 5210
UTP15 -10264 -8238 10459
UTP18 5055 3705 3978
UTP20 -10191 -6857 6223
UTP3 -2829 -1448 -1947
UTP4 -11142 -9295 -1037
UTP6 -4362 -5407 9675
WDR12 5156 -1289 5359
WDR18 -2260 -4315 -6073
WDR3 -6394 -7931 -33
WDR36 -3825 -5814 6003
WDR43 -7419 -8808 3001
WDR46 -10623 -6936 -9396
WDR75 -9593 -9170 7264
XRN2 9240 9220 2754



Hyaluronan metabolism

Hyaluronan metabolism
metric value
setSize 13
pMANOVA 0.00396
p.adjustMANOVA 0.00895
s.dist 0.682
s.t0_v_pod 0.513
s.pod_crp 0.369
s.t0_crp -0.258
p.t0_v_pod 0.00137
p.pod_crp 0.0213
p.t0_crp 0.108




Top 20 genes
Gene t0_v_pod pod_crp
HYAL2 8935 11497
SLC9A1 7847 11292
GUSB 7607 11238
CHP1 9101 9267
CD44 8201 8363
HEXB 8631 6847
HYAL1 4123 8509
ABCC5 2460 1806
HYAL3 5168 304

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All member genes
t0_v_pod pod_crp t0_crp
ABCC5 2460 1806 -3059
CD44 8201 8363 1308
CEMIP -7161 -3195 -4715
CHP1 9101 9267 -2016
GUSB 7607 11238 -5640
HAS3 -5989 259 -2842
HEXA 1251 -437 -3967
HEXB 8631 6847 3887
HMMR 3770 -3451 3745
HYAL1 4123 8509 6499
HYAL2 8935 11497 -6474
HYAL3 5168 304 -7308
SLC9A1 7847 11292 -6860



Lagging Strand Synthesis

Lagging Strand Synthesis
metric value
setSize 20
pMANOVA 0.000415
p.adjustMANOVA 0.00129
s.dist 0.68
s.t0_v_pod -0.452
s.pod_crp -0.487
s.t0_crp 0.146
p.t0_v_pod 0.000465
p.pod_crp 0.000161
p.t0_crp 0.26




Top 20 genes
Gene pod_crp t0_v_pod
POLA1 -9617 -11789
RPA1 -9614 -11644
POLD2 -9699 -10015
LIG1 -8575 -10705
RFC3 -8651 -10151
PRIM1 -8226 -9858
RFC4 -7694 -10361
FEN1 -7081 -10254
POLA2 -6182 -11222
RPA3 -8027 -8609
RFC5 -3955 -11357
PCNA -6800 -5771
RFC1 -5456 -7180
PRIM2 -5615 -5389
RPA2 -4586 -6094
DNA2 -3986 -2786

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All member genes
t0_v_pod pod_crp t0_crp
DNA2 -2786 -3986 9591
FEN1 -10254 -7081 -1614
LIG1 -10705 -8575 -5384
PCNA -5771 -6800 5825
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
RFC1 -7180 -5456 9242
RFC2 4890 4788 -676
RFC3 -10151 -8651 7668
RFC4 -10361 -7694 9525
RFC5 -11357 -3955 885
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



Josephin domain DUBs

Josephin domain DUBs
metric value
setSize 10
pMANOVA 0.00118
p.adjustMANOVA 0.00316
s.dist 0.674
s.t0_v_pod 0.47
s.pod_crp 0.0859
s.t0_crp -0.475
p.t0_v_pod 0.0101
p.pod_crp 0.638
p.t0_crp 0.00927




Top 20 genes
Gene t0_crp t0_v_pod
JOSD2 -8695 7810
VCP -5183 6789
UBB -4745 6548
RAD23A -4233 6424
UBC -4004 4395
RAD23B -1741 8738
UBA52 -7104 1112
JOSD1 -7775 225

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ATXN3 1588 -286 7221
JOSD1 225 -434 -7775
JOSD2 7810 10580 -8695
RAD23A 6424 2668 -4233
RAD23B 8738 8626 -1741
RPS27A -6700 -8679 -8103
UBA52 1112 -1425 -7104
UBB 6548 -2419 -4745
UBC 4395 4824 -4004
VCP 6789 4231 -5183



Pre-NOTCH Processing in Golgi

Pre-NOTCH Processing in Golgi
metric value
setSize 18
pMANOVA 0.000286
p.adjustMANOVA 0.000943
s.dist 0.673
s.t0_v_pod 0.411
s.pod_crp 0.399
s.t0_crp -0.354
p.t0_v_pod 0.00257
p.pod_crp 0.00337
p.t0_crp 0.00941




Top 20 genes
Gene t0_v_pod pod_crp
FURIN 8922 10150
NOTCH3 7778 11527
ATP2A2 7915 9550
RAB6A 8020 7487
ST3GAL4 5708 8030
NOTCH2 5211 8392
NOTCH1 4653 6904
SEL1L 6751 4671
RFNG 7126 4194
ST3GAL6 6610 3510
B4GALT1 4248 5054
TMED2 5971 962

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ATP2A1 -4516 8497 -2235
ATP2A2 7915 9550 -2449
ATP2A3 -905 -2587 -8401
B4GALT1 4248 5054 -5889
FURIN 8922 10150 -9942
LFNG -8085 6673 -4683
MFNG -5809 -7090 -9987
NOTCH1 4653 6904 -8024
NOTCH2 5211 8392 -4852
NOTCH3 7778 11527 -4938
NOTCH4 -5056 11286 -3210
RAB6A 8020 7487 7945
RFNG 7126 4194 -7257
SEL1L 6751 4671 4441
ST3GAL3 499 -5146 -5921
ST3GAL4 5708 8030 -8973
ST3GAL6 6610 3510 8941
TMED2 5971 962 8999



Translation initiation complex formation

Translation initiation complex formation
metric value
setSize 58
pMANOVA 4.84e-23
p.adjustMANOVA 1.53e-21
s.dist 0.666
s.t0_v_pod -0.0201
s.pod_crp -0.541
s.t0_crp -0.388
p.t0_v_pod 0.792
p.pod_crp 9.62e-13
p.t0_crp 3.15e-07




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPS5 -8655 -8821
RPS12 -8359 -9089
EIF3B -8831 -8507
RPS27 -8218 -8994
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
EIF3L -7724 -8957
RPS17 -7093 -9634
RPS10 -7587 -8910
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006
RPS6 -9127 -7094
RPS23 -8292 -7435
RPS21 -6666 -9210
RPS15A -7870 -7555
RPS11 -6701 -8383
RPS28 -6389 -8638

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
FAU -359 -1018 -9018
PABPC1 5290 -3454 4415
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058



COPI-independent Golgi-to-ER retrograde traffic

COPI-independent Golgi-to-ER retrograde traffic
metric value
setSize 33
pMANOVA 5.17e-07
p.adjustMANOVA 3.73e-06
s.dist 0.661
s.t0_v_pod 0.563
s.pod_crp 0.341
s.t0_crp 0.053
p.t0_v_pod 2.13e-08
p.pod_crp 0.000693
p.t0_crp 0.599




Top 20 genes
Gene t0_v_pod pod_crp
DCTN2 9002 10291
PLA2G4A 9025 9798
GALNT2 8697 10159
DCTN4 8255 9319
BICD2 8602 8523
ACTR1A 6899 9916
CAPZB 7893 8485
CAPZA2 8457 7902
DCTN6 7193 9197
CAPZA1 8008 7934
RAB6A 8020 7487
DYNC1LI1 6841 7785
DCTN3 5913 7789
DCTN1 5019 9090
AGPAT3 4753 9206
DYNC1I2 7619 5669
DYNC1LI2 4229 7994
RAB18 7683 4326
ACTR10 7490 4188
PAFAH1B1 5405 3703

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All member genes
t0_v_pod pod_crp t0_crp
ACTR10 7490 4188 6836
ACTR1A 6899 9916 -3005
AGPAT3 4753 9206 265
BICD1 -7111 -2457 1989
BICD2 8602 8523 -9628
CAPZA1 8008 7934 10601
CAPZA2 8457 7902 9795
CAPZB 7893 8485 -1774
DCTN1 5019 9090 -8825
DCTN2 9002 10291 -7838
DCTN3 5913 7789 -5083
DCTN4 8255 9319 8693
DCTN5 -3959 -889 -9162
DCTN6 7193 9197 10983
DYNC1H1 -7417 -1029 -6456
DYNC1I1 4145 1187 4638
DYNC1I2 7619 5669 8219
DYNC1LI1 6841 7785 8760
DYNC1LI2 4229 7994 3500
DYNLL1 5873 3157 -957
DYNLL2 -3859 -7973 -7679
GALNT1 6420 2592 7240
GALNT2 8697 10159 -7925
PAFAH1B1 5405 3703 -863
PAFAH1B2 6842 2339 6018
PAFAH1B3 4373 -4344 -7981
PLA2G4A 9025 9798 9511
PLA2G6 -11761 -5182 -9297
RAB18 7683 4326 11226
RAB3GAP1 5695 2587 10098
RAB3GAP2 4385 3283 9655
RAB6A 8020 7487 7945
RAB6B 5972 -3767 -9692



Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
metric value
setSize 58
pMANOVA 3.07e-22
p.adjustMANOVA 9.23e-21
s.dist 0.657
s.t0_v_pod -0.0251
s.pod_crp -0.536
s.t0_crp -0.378
p.t0_v_pod 0.741
p.pod_crp 1.54e-12
p.t0_crp 6.22e-07




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPS5 -8655 -8821
RPS12 -8359 -9089
EIF3B -8831 -8507
RPS27 -8218 -8994
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
EIF3L -7724 -8957
RPS17 -7093 -9634
RPS10 -7587 -8910
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006
RPS6 -9127 -7094
RPS23 -8292 -7435
RPS21 -6666 -9210
RPS15A -7870 -7555
RPS11 -6701 -8383
RPS28 -6389 -8638

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
EIF5 2162 -411 10513
FAU -359 -1018 -9018
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058



Processive synthesis on the lagging strand

Processive synthesis on the lagging strand
metric value
setSize 15
pMANOVA 0.00714
p.adjustMANOVA 0.0148
s.dist 0.656
s.t0_v_pod -0.431
s.pod_crp -0.492
s.t0_crp 0.0478
p.t0_v_pod 0.00386
p.pod_crp 0.000965
p.t0_crp 0.748




Top 20 genes
Gene pod_crp t0_v_pod
POLA1 -9617 -11789
RPA1 -9614 -11644
POLD2 -9699 -10015
LIG1 -8575 -10705
PRIM1 -8226 -9858
FEN1 -7081 -10254
POLA2 -6182 -11222
RPA3 -8027 -8609
PCNA -6800 -5771
PRIM2 -5615 -5389
RPA2 -4586 -6094
DNA2 -3986 -2786

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All member genes
t0_v_pod pod_crp t0_crp
DNA2 -2786 -3986 9591
FEN1 -10254 -7081 -1614
LIG1 -10705 -8575 -5384
PCNA -5771 -6800 5825
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
metric value
setSize 59
pMANOVA 6.82e-23
p.adjustMANOVA 2.11e-21
s.dist 0.654
s.t0_v_pod -0.00808
s.pod_crp -0.525
s.t0_crp -0.389
p.t0_v_pod 0.915
p.pod_crp 2.92e-12
p.t0_crp 2.27e-07




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPS5 -8655 -8821
RPS12 -8359 -9089
EIF3B -8831 -8507
RPS27 -8218 -8994
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
EIF3L -7724 -8957
RPS17 -7093 -9634
RPS10 -7587 -8910
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006
RPS6 -9127 -7094
RPS23 -8292 -7435
RPS21 -6666 -9210
RPS15A -7870 -7555
RPS11 -6701 -8383
RPS28 -6389 -8638

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EIF1AX 1081 -8352 8447
EIF2S1 4235 -3323 9204
EIF2S2 6091 297 8972
EIF2S3 6653 1299 9884
EIF3A 2132 -1524 1889
EIF3B -7776 -8831 -8507
EIF3C 285 -3719 -9547
EIF3D 2605 -4304 -5425
EIF3E 1902 -8557 7960
EIF3F 970 -3717 -9911
EIF3G 871 -1661 -9388
EIF3H 4677 -5855 -1314
EIF3I 4649 -2647 -7649
EIF3J 1885 -5962 9440
EIF3K 1468 -294 -5982
EIF3L 2560 -7724 -8957
EIF3M 4533 -5583 8254
EIF4A1 7476 5864 1477
EIF4A2 -10809 -9312 9673
EIF4B 1237 -8286 -6402
EIF4E 4757 2088 11218
EIF4EBP1 5990 5279 -4330
EIF4G1 7908 9779 -6766
EIF4H 7634 7346 -9456
FAU -359 -1018 -9018
PABPC1 5290 -3454 4415
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058



Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization
metric value
setSize 14
pMANOVA 0.00285
p.adjustMANOVA 0.00668
s.dist 0.654
s.t0_v_pod 0.549
s.pod_crp 0.315
s.t0_crp 0.161
p.t0_v_pod 0.000374
p.pod_crp 0.041
p.t0_crp 0.296




Top 20 genes
Gene t0_v_pod pod_crp
RAB1A 8899 9776
MAPK3 8803 9501
MAPK1 7381 10667
RAB1B 8182 9315
GORASP1 6516 10810
RAB2A 8464 7935
GOLGA2 6117 8262
CCNB2 3649 3856
PLK1 2978 2945
BLZF1 3253 482

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All member genes
t0_v_pod pod_crp t0_crp
BLZF1 3253 482 11272
CCNB1 461 -2501 5748
CCNB2 3649 3856 5384
CDK1 1527 -5531 8795
GOLGA2 6117 8262 -6169
GORASP1 6516 10810 321
GORASP2 -6792 -6318 2542
MAPK1 7381 10667 -1770
MAPK3 8803 9501 -9768
PLK1 2978 2945 -2313
RAB1A 8899 9776 8679
RAB1B 8182 9315 -8932
RAB2A 8464 7935 8400
USO1 4113 -107 10935



EPHB-mediated forward signaling

EPHB-mediated forward signaling
metric value
setSize 32
pMANOVA 8.75e-06
p.adjustMANOVA 4.57e-05
s.dist 0.653
s.t0_v_pod 0.504
s.pod_crp 0.387
s.t0_crp 0.152
p.t0_v_pod 8.17e-07
p.pod_crp 0.000154
p.t0_crp 0.136




Top 20 genes
Gene t0_v_pod pod_crp
ITSN1 9131 10746
ARPC1B 9102 10772
ARPC1A 8745 11015
RAC1 8647 10726
ACTB 8859 10253
PAK1 8100 10529
ARPC5 8544 9897
LYN 7691 10712
CFL1 8057 9547
ARPC3 8147 9352
ACTG1 8423 8439
RHOA 8188 8640
ARPC4 7404 9098
ARPC2 7280 9088
LIMK2 7949 8071
ACTR2 7750 7266
CDC42 7425 7251
ROCK1 7377 6942
ACTR3 7699 6569
LIMK1 4628 9134

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ACTB 8859 10253 -883
ACTG1 8423 8439 -7587
ACTR2 7750 7266 8225
ACTR3 7699 6569 7217
ARHGEF28 -9954 -541 4640
ARPC1A 8745 11015 5898
ARPC1B 9102 10772 -7161
ARPC2 7280 9088 4584
ARPC3 8147 9352 7298
ARPC4 7404 9098 -762
ARPC5 8544 9897 5412
CDC42 7425 7251 8682
CFL1 8057 9547 -7188
FYN -11320 -6579 -4817
HRAS -3288 -3089 -7583
ITSN1 9131 10746 8907
KALRN -3584 -8861 -4318
LIMK1 4628 9134 -7403
LIMK2 7949 8071 -2143
LYN 7691 10712 7722
PAK1 8100 10529 8872
PTK2 4418 -3305 -1920
RAC1 8647 10726 9288
RASA1 2093 6650 9826
RHOA 8188 8640 7321
ROCK1 7377 6942 10322
ROCK2 6054 5462 6111
SDC2 5335 231 3734
SRC -8520 -5490 -4085
TIAM1 645 -2277 -4599
WASL 297 -1358 7215
YES1 -11781 -5623 1760



Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
metric value
setSize 24
pMANOVA 0.000369
p.adjustMANOVA 0.00118
s.dist 0.648
s.t0_v_pod -0.445
s.pod_crp -0.47
s.t0_crp 0.0352
p.t0_v_pod 0.000159
p.pod_crp 6.79e-05
p.t0_crp 0.766




Top 20 genes
Gene pod_crp t0_v_pod
RPA1 -9614 -11644
PARP1 -9090 -11409
POLE3 -8881 -11228
POLD2 -9699 -10015
APEX1 -9662 -9998
LIG1 -8575 -10705
RFC3 -8651 -10151
RFC4 -7694 -10361
FEN1 -7081 -10254
RPA3 -8027 -8609
POLE2 -6619 -9613
PARP2 -5348 -11860
RFC5 -3955 -11357
PCNA -6800 -5771
RFC1 -5456 -7180
POLB -4341 -7276
RPA2 -4586 -6094
POLE -1466 -7317

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
APEX1 -9998 -9662 -5836
FEN1 -10254 -7081 -1614
LIG1 -10705 -8575 -5384
PARG -653 84 -12
PARP1 -11409 -9090 -4667
PARP2 -11860 -5348 9470
PCNA -5771 -6800 5825
POLB -7276 -4341 9678
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
POLE -7317 -1466 -857
POLE2 -9613 -6619 10055
POLE3 -11228 -8881 -6530
POLE4 5453 -1174 -1480
RFC1 -7180 -5456 9242
RFC2 4890 4788 -676
RFC3 -10151 -8651 7668
RFC4 -10361 -7694 9525
RFC5 -11357 -3955 885
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



Generation of second messenger molecules

Generation of second messenger molecules
metric value
setSize 38
pMANOVA 3.21e-06
p.adjustMANOVA 1.85e-05
s.dist 0.647
s.t0_v_pod -0.464
s.pod_crp -0.45
s.t0_crp -0.0116
p.t0_v_pod 7.22e-07
p.pod_crp 1.59e-06
p.t0_crp 0.901




Top 20 genes
Gene t0_v_pod pod_crp
CD247 -11982 -9454
LCK -11482 -9442
LAT -11339 -9116
TRAC -11130 -9287
CD3E -10952 -9335
CD3G -11173 -9082
EVL -11846 -8538
TRBC1 -11646 -8623
ITK -10875 -9188
ZAP70 -11590 -8619
TRBV12-3 -10099 -9681
NCK1 -11102 -8778
CD3D -11049 -8704
PLCG1 -10772 -8454
TRAV19 -9587 -9353
HLA-DPB1 -11887 -7068
HLA-DQB2 -9085 -8978
TRAV29DV5 -9353 -8284
HLA-DRA -11649 -6573
HLA-DPA1 -11954 -5815

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All member genes
t0_v_pod pod_crp t0_crp
CD101 4105 550 1390
CD247 -11982 -9454 -8935
CD3D -11049 -8704 2046
CD3E -10952 -9335 5813
CD3G -11173 -9082 6756
CD4 -5228 -4848 -1251
ENAH -2639 6886 6088
EVL -11846 -8538 -5843
GRAP2 4639 -6196 -6175
HLA-DPA1 -11954 -5815 946
HLA-DPB1 -11887 -7068 -7160
HLA-DQA1 -11633 -1453 9693
HLA-DQA2 -4652 -9364 -9927
HLA-DQB1 -6199 3626 5107
HLA-DQB2 -9085 -8978 -9720
HLA-DRA -11649 -6573 2695
HLA-DRB1 -7792 1344 9366
HLA-DRB5 -4806 -1108 9092
ITK -10875 -9188 -1992
LAT -11339 -9116 -2696
LCK -11482 -9442 -4194
LCP2 -1141 513 7373
NCK1 -11102 -8778 9958
PAK1 8100 10529 8872
PAK2 8056 5729 8015
PAK3 -4054 -528 1055
PLCG1 -10772 -8454 -1778
PLCG2 4947 10212 -3380
TRAC -11130 -9287 8688
TRAV19 -9587 -9353 -6593
TRAV29DV5 -9353 -8284 4257
TRAV8-4 -7010 -7565 10068
TRBC1 -11646 -8623 -1744
TRBV12-3 -10099 -9681 -6812
TRBV7-9 -9220 -6700 -5268
VASP 7904 9635 -3011
WAS 8421 11046 -2152
ZAP70 -11590 -8619 -9003



Mucopolysaccharidoses

Mucopolysaccharidoses
metric value
setSize 11
pMANOVA 0.0202
p.adjustMANOVA 0.0369
s.dist 0.643
s.t0_v_pod 0.455
s.pod_crp 0.373
s.t0_crp -0.259
p.t0_v_pod 0.009
p.pod_crp 0.0322
p.t0_crp 0.136




Top 20 genes
Gene t0_v_pod pod_crp
GNS 9200 11391
GLB1 8581 10666
GUSB 7607 11238
ARSB 7459 10240
GALNS 6998 9617
HYAL1 4123 8509
SGSH 5835 1563

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All member genes
t0_v_pod pod_crp t0_crp
ARSB 7459 10240 3628
GALNS 6998 9617 -5269
GLB1 8581 10666 2258
GNS 9200 11391 3599
GUSB 7607 11238 -5640
HGSNAT 1854 -3565 -171
HYAL1 4123 8509 6499
IDS -2558 -4092 -5186
IDUA -5636 -4194 -4093
NAGLU -4608 1834 -9402
SGSH 5835 1563 -9672



Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
metric value
setSize 11
pMANOVA 0.0446
p.adjustMANOVA 0.0729
s.dist 0.635
s.t0_v_pod 0.476
s.pod_crp 0.42
s.t0_crp -0.0153
p.t0_v_pod 0.00629
p.pod_crp 0.0159
p.t0_crp 0.93




Top 20 genes
Gene t0_v_pod pod_crp
LYN 7691 10712
IRS2 8429 9184
EPOR 7117 10209
GAB1 5607 9590
PIK3CB 8886 6045
PIK3CD 5965 6435
PIK3CG 1820 6282
JAK2 2670 3748

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
EPOR 7117 10209 -3997
GAB1 5607 9590 8595
IRS2 8429 9184 -8741
JAK2 2670 3748 10899
LYN 7691 10712 7722
PIK3CA 4580 -1120 7526
PIK3CB 8886 6045 5645
PIK3CD 5965 6435 -8659
PIK3CG 1820 6282 395
PIK3R1 -9187 -9263 -4851
PIK3R5 -2255 6885 -9286



Nucleobase biosynthesis

Nucleobase biosynthesis
metric value
setSize 13
pMANOVA 0.0172
p.adjustMANOVA 0.0322
s.dist 0.632
s.t0_v_pod -0.356
s.pod_crp -0.507
s.t0_crp -0.121
p.t0_v_pod 0.0263
p.pod_crp 0.00153
p.t0_crp 0.449




Top 20 genes
Gene pod_crp t0_v_pod
ATIC -9716 -10848
PPAT -9651 -10811
UMPS -9647 -10137
IMPDH2 -9804 -9588
PFAS -8589 -10685
CAD -8282 -9437
PAICS -9083 -5189
GMPS -6546 -5248
DHODH -2252 -5446

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ADSL 5026 -3176 2734
ATIC -10848 -9716 3712
CAD -9437 -8282 -7092
DHODH -5446 -2252 -6133
GART -3463 5764 8370
GMPS -5248 -6546 4467
IMPDH1 9136 11141 -3002
IMPDH2 -9588 -9804 -8220
LHPP 11 422 -3201
PAICS -5189 -9083 6955
PFAS -10685 -8589 -10001
PPAT -10811 -9651 5933
UMPS -10137 -9647 -3028



Transferrin endocytosis and recycling

Transferrin endocytosis and recycling
metric value
setSize 26
pMANOVA 0.000131
p.adjustMANOVA 0.000478
s.dist 0.629
s.t0_v_pod 0.509
s.pod_crp 0.367
s.t0_crp -0.0437
p.t0_v_pod 7.03e-06
p.pod_crp 0.00119
p.t0_crp 0.7




Top 20 genes
Gene t0_v_pod pod_crp
ATP6V0A1 9262 11270
ATP6V0D1 9088 11089
ATP6V0C 8974 10678
ATP6AP1 8032 11319
ATP6V0B 8458 10337
ATP6V1B2 8904 9564
ATP6V1D 8894 9569
MCOLN1 7624 10948
TCIRG1 7082 11503
ATP6V1A 9144 8379
ATP6V1C1 8400 8697
ATP6V0E1 8456 8200
STEAP3 5915 10624
ATP6V1E1 7912 7496
ATP6V1H 7939 4992
ATP6V1F 5802 5090
HFE 8632 3038
TFRC 1513 3020
TF 1093 3741

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ATP6AP1 8032 11319 -7483
ATP6V0A1 9262 11270 -184
ATP6V0A2 -11850 -4901 2656
ATP6V0B 8458 10337 -6528
ATP6V0C 8974 10678 -1938
ATP6V0D1 9088 11089 -1722
ATP6V0E1 8456 8200 -226
ATP6V0E2 -11202 -8309 1787
ATP6V1A 9144 8379 5839
ATP6V1B2 8904 9564 3425
ATP6V1C1 8400 8697 8360
ATP6V1C2 -2175 -2046 -2521
ATP6V1D 8894 9569 8256
ATP6V1E1 7912 7496 8195
ATP6V1E2 5657 -5806 -7499
ATP6V1F 5802 5090 -6651
ATP6V1G1 3892 -4430 794
ATP6V1G2 -9197 -8007 -1854
ATP6V1H 7939 4992 5368
HFE 8632 3038 3027
MCOLN1 7624 10948 -3372
STEAP3 5915 10624 -4813
TCIRG1 7082 11503 -5720
TF 1093 3741 3826
TFR2 -9464 -1997 -6265
TFRC 1513 3020 9770



Pentose phosphate pathway

Pentose phosphate pathway
metric value
setSize 13
pMANOVA 0.0108
p.adjustMANOVA 0.0213
s.dist 0.627
s.t0_v_pod 0.488
s.pod_crp 0.339
s.t0_crp -0.202
p.t0_v_pod 0.00233
p.pod_crp 0.0343
p.t0_crp 0.207




Top 20 genes
Gene t0_v_pod pod_crp
PGD 9320 10993
TKT 9183 10517
TALDO1 9295 10245
G6PD 8853 10755
PGM2 9185 9410
DERA 8364 9539
PGLS 5997 4969
RPE 2570 7746

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All member genes
t0_v_pod pod_crp t0_crp
DERA 8364 9539 9162
G6PD 8853 10755 -9506
PGD 9320 10993 -4711
PGLS 5997 4969 -9140
PGM2 9185 9410 3358
PRPS1 -11716 -9510 -3761
PRPS2 3530 -3692 6923
RBKS -3058 3558 -2088
RPE 2570 7746 4702
RPIA 1431 -5639 -5803
SHPK -2467 -743 -914
TALDO1 9295 10245 -1183
TKT 9183 10517 -6792



PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair
metric value
setSize 21
pMANOVA 0.00182
p.adjustMANOVA 0.00457
s.dist 0.624
s.t0_v_pod -0.42
s.pod_crp -0.461
s.t0_crp 0.0274
p.t0_v_pod 0.000864
p.pod_crp 0.000252
p.t0_crp 0.828




Top 20 genes
Gene pod_crp t0_v_pod
RPA1 -9614 -11644
POLE3 -8881 -11228
POLD2 -9699 -10015
APEX1 -9662 -9998
LIG1 -8575 -10705
RFC3 -8651 -10151
RFC4 -7694 -10361
FEN1 -7081 -10254
RPA3 -8027 -8609
POLE2 -6619 -9613
RFC5 -3955 -11357
PCNA -6800 -5771
RFC1 -5456 -7180
POLB -4341 -7276
RPA2 -4586 -6094
POLE -1466 -7317

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
APEX1 -9998 -9662 -5836
FEN1 -10254 -7081 -1614
LIG1 -10705 -8575 -5384
PCNA -5771 -6800 5825
POLB -7276 -4341 9678
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
POLE -7317 -1466 -857
POLE2 -9613 -6619 10055
POLE3 -11228 -8881 -6530
POLE4 5453 -1174 -1480
RFC1 -7180 -5456 9242
RFC2 4890 4788 -676
RFC3 -10151 -8651 7668
RFC4 -10361 -7694 9525
RFC5 -11357 -3955 885
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



Telomere C-strand synthesis initiation

Telomere C-strand synthesis initiation
metric value
setSize 13
pMANOVA 0.0159
p.adjustMANOVA 0.0299
s.dist 0.624
s.t0_v_pod -0.361
s.pod_crp -0.509
s.t0_crp 0.0113
p.t0_v_pod 0.0243
p.pod_crp 0.00148
p.t0_crp 0.944




Top 20 genes
Gene pod_crp t0_v_pod
POLA1 -9617 -11789
STN1 -9456 -9115
CTC1 -7964 -10458
PRIM1 -8226 -9858
POLA2 -6182 -11222
PRIM2 -5615 -5389
ACD -3932 -7528
POT1 -5802 -4217
TERF2 -4892 -4319
TERF1 -3782 -3495

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ACD -7528 -3932 -6437
CTC1 -10458 -7964 -6857
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POT1 -4217 -5802 9768
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
STN1 -9115 -9456 -5229
TEN1 501 1024 -6572
TERF1 -3495 -3782 8554
TERF2 -4319 -4892 4689
TERF2IP 4981 -1097 -3306
TINF2 4545 5884 -4471



Telomere C-strand (Lagging Strand) Synthesis

Telomere C-strand (Lagging Strand) Synthesis
metric value
setSize 34
pMANOVA 1.41e-05
p.adjustMANOVA 7.06e-05
s.dist 0.622
s.t0_v_pod -0.387
s.pod_crp -0.486
s.t0_crp 0.0205
p.t0_v_pod 9.4e-05
p.pod_crp 9.35e-07
p.t0_crp 0.836




Top 20 genes
Gene pod_crp t0_v_pod
POLA1 -9617 -11789
RPA1 -9614 -11644
WRN -9054 -11687
CHTF18 -8742 -11774
POLD2 -9699 -10015
LIG1 -8575 -10705
RFC3 -8651 -10151
STN1 -9456 -9115
CTC1 -7964 -10458
PRIM1 -8226 -9858
RFC4 -7694 -10361
FEN1 -7081 -10254
POLA2 -6182 -11222
RPA3 -8027 -8609
RFC5 -3955 -11357
PCNA -6800 -5771
RFC1 -5456 -7180
DSCC1 -7629 -4742
PRIM2 -5615 -5389
ACD -3932 -7528

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
ACD -7528 -3932 -6437
BLM -4539 -4399 3954
CHTF18 -11774 -8742 -9681
CHTF8 -593 -498 -6962
CTC1 -10458 -7964 -6857
DNA2 -2786 -3986 9591
DSCC1 -4742 -7629 3907
FEN1 -10254 -7081 -1614
LIG1 -10705 -8575 -5384
PCNA -5771 -6800 5825
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
POT1 -4217 -5802 9768
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
RFC1 -7180 -5456 9242
RFC2 4890 4788 -676
RFC3 -10151 -8651 7668
RFC4 -10361 -7694 9525
RFC5 -11357 -3955 885
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201
STN1 -9115 -9456 -5229
TEN1 501 1024 -6572
TERF1 -3495 -3782 8554
TERF2 -4319 -4892 4689
TERF2IP 4981 -1097 -3306
TINF2 4545 5884 -4471
WRN -11687 -9054 3951



Removal of the Flap Intermediate

Removal of the Flap Intermediate
metric value
setSize 14
pMANOVA 0.0153
p.adjustMANOVA 0.029
s.dist 0.619
s.t0_v_pod -0.399
s.pod_crp -0.464
s.t0_crp 0.0915
p.t0_v_pod 0.00975
p.pod_crp 0.00263
p.t0_crp 0.553




Top 20 genes
Gene pod_crp t0_v_pod
POLA1 -9617 -11789
RPA1 -9614 -11644
POLD2 -9699 -10015
PRIM1 -8226 -9858
FEN1 -7081 -10254
POLA2 -6182 -11222
RPA3 -8027 -8609
PCNA -6800 -5771
PRIM2 -5615 -5389
RPA2 -4586 -6094
DNA2 -3986 -2786

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
DNA2 -2786 -3986 9591
FEN1 -10254 -7081 -1614
PCNA -5771 -6800 5825
POLA1 -11789 -9617 -2014
POLA2 -11222 -6182 7454
POLD1 202 644 -8553
POLD2 -10015 -9699 -6885
POLD3 8737 11080 8461
POLD4 6250 10181 -6882
PRIM1 -9858 -8226 8710
PRIM2 -5389 -5615 5609
RPA1 -11644 -9614 -4577
RPA2 -6094 -4586 5338
RPA3 -8609 -8027 2201



Regulation of IFNG signaling

Regulation of IFNG signaling
metric value
setSize 14
pMANOVA 0.0106
p.adjustMANOVA 0.0211
s.dist 0.619
s.t0_v_pod 0.396
s.pod_crp 0.328
s.t0_crp 0.345
p.t0_v_pod 0.0103
p.pod_crp 0.0337
p.t0_crp 0.0256




Top 20 genes
Gene t0_v_pod t0_crp
PIAS1 7251 11245
IFNGR1 9116 8908
IFNGR2 9081 7500
SUMO1 6791 9971
PTPN2 7500 7302
SOCS1 3908 8555
JAK2 2670 10899

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
IFNG -9944 -5918 10671
IFNGR1 9116 10216 8908
IFNGR2 9081 11379 7500
JAK1 -10608 -8056 -7913
JAK2 2670 3748 10899
PIAS1 7251 4527 11245
PTPN1 5649 9613 -2841
PTPN11 5253 2833 -599
PTPN2 7500 10261 7302
PTPN6 6014 11061 -2766
SOCS1 3908 6589 8555
SOCS3 9315 10466 -9983
STAT1 -11372 -9361 9559
SUMO1 6791 3579 9971



Signal transduction by L1

Signal transduction by L1
metric value
setSize 20
pMANOVA 0.00318
p.adjustMANOVA 0.00737
s.dist 0.615
s.t0_v_pod 0.438
s.pod_crp 0.429
s.t0_crp -0.0468
p.t0_v_pod 0.00069
p.pod_crp 0.000886
p.t0_crp 0.717




Top 20 genes
Gene t0_v_pod pod_crp
RAC1 8647 10726
MAP2K1 8910 10086
PAK1 8100 10529
MAPK3 8803 9501
MAPK1 7381 10667
ITGA5 7543 10003
ITGA9 6840 7705
ITGAV 6022 8016
CSNK2A1 6113 7887
MAP2K2 6699 5024
CSNK2A2 6301 4283
CSNK2B 3930 6489
ITGA2B 8744 1914

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CSNK2A1 6113 7887 3044
CSNK2A2 6301 4283 1985
CSNK2B 3930 6489 169
FGFR1 -5175 9868 7234
ITGA2B 8744 1914 -6113
ITGA5 7543 10003 -7138
ITGA9 6840 7705 -14
ITGAV 6022 8016 5164
ITGB1 -94 -4816 8046
ITGB3 8161 -2845 -6419
L1CAM -6144 -1630 6391
MAP2K1 8910 10086 -3295
MAP2K2 6699 5024 -9806
MAPK1 7381 10667 -1770
MAPK3 8803 9501 -9768
NCAM1 -11351 -7493 -9093
NRP1 -8419 5434 8016
PAK1 8100 10529 8872
RAC1 8647 10726 9288
VAV2 -3931 7387 -1965



Gap junction trafficking and regulation

Gap junction trafficking and regulation
metric value
setSize 15
pMANOVA 0.00695
p.adjustMANOVA 0.0145
s.dist 0.615
s.t0_v_pod 0.414
s.pod_crp 0.38
s.t0_crp -0.249
p.t0_v_pod 0.00554
p.pod_crp 0.0108
p.t0_crp 0.0944




Top 20 genes
Gene t0_v_pod pod_crp
DAB2 7985 10708
GJD3 7874 10701
CLTC 8849 9216
CLTCL1 8815 8901
CLTA 8244 7587
AP2M1 8486 7237
DNM2 6007 9598
CLTB 6002 8174
DNM1 3555 5772
GJC1 512 5804
GJC2 1074 2370

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AP2M1 8486 7237 -8627
CLTA 8244 7587 492
CLTB 6002 8174 -8503
CLTC 8849 9216 1230
CLTCL1 8815 8901 -5432
DAB2 7985 10708 -7018
DNM1 3555 5772 7505
DNM2 6007 9598 -9051
GJB6 4708 -4124 -9998
GJC1 512 5804 1908
GJC2 1074 2370 -2725
GJD3 7874 10701 1754
MYO6 -11058 -7648 6236
SRC -8520 -5490 -4085
TJP1 -6159 4874 5957



Influenza Infection

Influenza Infection
metric value
setSize 154
pMANOVA 5.68e-35
p.adjustMANOVA 2.76e-33
s.dist 0.614
s.t0_v_pod -0.181
s.pod_crp -0.498
s.t0_crp -0.311
p.t0_v_pod 0.000107
p.pod_crp 1.37e-26
p.t0_crp 2.75e-11




Top 20 genes
Gene pod_crp t0_crp
RPS2 -9592 -9910
RPL3 -9658 -9541
RPLP2 -8213 -9852
RPS5 -8655 -8821
RPS12 -8359 -9089
RPLP0 -8648 -8726
RPS27 -8218 -8994
RPL27A -8378 -8710
RPS3 -8813 -8148
RPS16 -7575 -9312
RPS27A -8679 -8103
RPL10 -8276 -8457
RPS17 -7093 -9634
RPL29 -7912 -8580
RPS10 -7587 -8910
RPL37 -6620 -9973
RPL35 -7668 -8594
RPS29 -6750 -9717
RPS14 -8295 -7890
RPS18 -7246 -9006

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AAAS -8101 625 -1546
CALR 6254 4913 2943
CANX 5462 -1266 3299
CLTA 8244 7587 492
CLTC 8849 9216 1230
CPSF4 -9100 -2297 -7726
DNAJC3 8302 8189 7460
EIF2AK2 -8803 425 11281
FAU -359 -1018 -9018
GRSF1 5110 -3098 3896
GTF2F1 4893 5437 -9039
GTF2F2 5371 5207 5137
HSP90AA1 1316 -5048 8114
HSPA1A 7946 6632 -7658
IPO5 -10252 -9795 -1839
ISG15 -11672 -6773 9458
KPNA1 1286 -4246 7790
KPNA2 -6675 -3820 5987
KPNA3 916 -4231 8690
KPNA4 4899 -694 9510
KPNA5 -11535 -7514 9592
KPNB1 2414 -106 6972
NDC1 -11812 -9774 -73
NUP107 -10085 -8758 7683
NUP133 -7491 -5635 5219
NUP153 -6108 -4400 3509
NUP155 -9900 -7591 2977
NUP160 -10219 -8656 3162
NUP188 -11270 -7253 -5615
NUP205 -10971 -7010 3379
NUP210 -10384 -4340 -8792
NUP214 7800 9971 2007
NUP35 -10272 -9583 8608
NUP37 3049 -1412 3817
NUP42 -5378 -2693 10509
NUP43 -9198 -7750 10186
NUP50 4476 -1230 6822
NUP54 -8189 -5304 11136
NUP58 8674 7535 6567
NUP62 763 394 -2984
NUP85 -2971 -1702 6335
NUP88 -11046 -9387 4338
NUP93 -11266 -3136 2920
NUP98 3075 175 2062
PABPN1 -522 2552 -4617
PARP1 -11409 -9090 -4667
POLR2A -3010 6319 -6014
POLR2B -2462 -5075 7311
POLR2C 1603 -2543 -2871
POLR2D -3902 -8118 4726
POLR2E 7450 5182 -8728
POLR2F 4555 5678 -8849
POLR2G 3477 5635 -7724
POLR2H -2867 -3580 -4558
POLR2I 394 -1586 -8884
POLR2J 6580 7886 -5760
POLR2K -1750 -3871 9561
POLR2L 5244 3421 -9948
POM121 -8013 -2273 -8608
POM121C -6940 -6034 -9057
RAE1 5105 4986 5899
RAN -6558 -7535 4893
RANBP2 -814 -3082 5483
RPL10 -6311 -8276 -8457
RPL10A -6458 -7947 -4624
RPL11 -6052 -7886 -4998
RPL12 -6811 -8646 -7155
RPL13 -3335 -5513 -5453
RPL13A -7928 -8645 -5039
RPL14 -6480 -9347 -6157
RPL15 -953 -7338 -6665
RPL17 -5249 -8419 -6788
RPL18 -4911 -7739 -7441
RPL18A -5869 -7567 -8492
RPL19 -6071 -6965 -6447
RPL21 -6241 -8730 -6047
RPL22 -4587 -8872 -6349
RPL22L1 -1593 -7786 8002
RPL23 -3223 -6892 -4274
RPL23A -9248 -9339 132
RPL24 -5606 -7584 -3780
RPL26 -6387 -7606 -5157
RPL26L1 7070 6121 -2311
RPL27 -2783 -6028 -8397
RPL27A -6048 -8378 -8710
RPL28 -1441 -1935 -5060
RPL29 -3505 -7912 -8580
RPL3 -8268 -9658 -9541
RPL30 -6779 -7741 -7518
RPL31 -4394 -7479 -7951
RPL32 -6479 -7872 -7788
RPL34 -6569 -8446 -2156
RPL35 -7809 -7668 -8594
RPL35A -5816 -8004 -6715
RPL36 -5111 -6303 -9572
RPL36A -7122 -8088 -5733
RPL36AL 32 -4117 -8959
RPL37 -6160 -6620 -9973
RPL37A -3826 -4740 -8543
RPL38 -5646 -6549 -9370
RPL39 -2931 -5751 -7976
RPL39L -8506 -67 -5602
RPL3L 4458 5640 8642
RPL4 -3476 -9022 -5587
RPL41 -6632 -6026 -7914
RPL5 -4576 -9316 -5226
RPL6 -3262 -8455 1237
RPL7 -1917 -9091 -6390
RPL7A -3557 -7254 -8652
RPL8 -1171 -6234 -9415
RPL9 -1837 -7409 -2348
RPLP0 -987 -8648 -8726
RPLP1 19 -3856 -9181
RPLP2 -6844 -8213 -9852
RPS10 -5601 -7587 -8910
RPS11 -6992 -6701 -8383
RPS12 -5788 -8359 -9089
RPS13 -1717 -7333 -4963
RPS14 -5278 -8295 -7890
RPS15 -3565 -5306 -7387
RPS15A -5550 -7870 -7555
RPS16 -4518 -7575 -9312
RPS17 -6038 -7093 -9634
RPS18 -7474 -7246 -9006
RPS19 -6725 -5579 -8515
RPS2 -4354 -9592 -9910
RPS20 -8585 -8433 -2895
RPS21 -3952 -6666 -9210
RPS23 -6081 -8292 -7435
RPS24 -261 -5274 -85
RPS25 -6151 -8789 -5448
RPS26 -1410 -5487 -3548
RPS27 -9432 -8218 -8994
RPS27A -6700 -8679 -8103
RPS27L 2048 2760 9265
RPS28 -4562 -6389 -8638
RPS29 -7664 -6750 -9717
RPS3 -5717 -8813 -8148
RPS3A -4543 -9214 3045
RPS4X -6075 -7594 1751
RPS4Y1 418 1451 -9138
RPS5 -5502 -8655 -8821
RPS6 -5956 -9127 -7094
RPS7 -4803 -8005 -6317
RPS8 -2041 -7120 -2938
RPS9 5358 2375 -7391
RPSA -6110 -4526 5058
SEC13 5675 6716 -3023
SEH1L -5868 -8749 9484
SLC25A6 6178 -5544 -10049
TGFB1 5094 -609 -7809
TPR -6786 -4096 4769
UBA52 1112 -1425 -7104
XPO1 -1169 -4173 11053



Negative regulation of MET activity

Negative regulation of MET activity
metric value
setSize 18
pMANOVA 0.00161
p.adjustMANOVA 0.00411
s.dist 0.61
s.t0_v_pod 0.526
s.pod_crp 0.31
s.t0_crp -0.0164
p.t0_v_pod 0.000112
p.pod_crp 0.023
p.t0_crp 0.904




Top 20 genes
Gene t0_v_pod pod_crp
GRB2 9146 10742
HGF 8715 10153
PTPN2 7500 10261
PTPRJ 7666 9296
SH3GL1 7509 9186
CBL 7368 8653
PTPN1 5649 9613
HGS 4468 9794
USP8 6330 6457
STAM2 6075 4706
UBC 4395 4824
EPS15 4097 3818
SH3KBP1 6089 1663

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CBL 7368 8653 -2568
EPS15 4097 3818 11150
GRB2 9146 10742 73
HGF 8715 10153 7901
HGS 4468 9794 -1894
LRIG1 -10053 -9333 -2404
PTPN1 5649 9613 -2841
PTPN2 7500 10261 7302
PTPRJ 7666 9296 -4702
RPS27A -6700 -8679 -8103
SH3GL1 7509 9186 -8172
SH3KBP1 6089 1663 3282
STAM 1275 -2469 3705
STAM2 6075 4706 10373
UBA52 1112 -1425 -7104
UBB 6548 -2419 -4745
UBC 4395 4824 -4004
USP8 6330 6457 11140



Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)

Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
metric value
setSize 12
pMANOVA 0.00104
p.adjustMANOVA 0.00284
s.dist 0.61
s.t0_v_pod 0.478
s.pod_crp 0.0954
s.t0_crp -0.366
p.t0_v_pod 0.00412
p.pod_crp 0.567
p.t0_crp 0.028




Top 20 genes
Gene t0_v_pod t0_crp
F12 9331 -8919
GP9 7394 -8439
VWF 6550 -8508
GP1BB 7358 -7237
GP1BA 6193 -6485
TPST2 5652 -5771
TPST1 9094 -2442
GP5 1285 -3763
GGCX 5176 -486

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
F12 9331 11462 -8919
F8 6919 4727 5869
GGCX 5176 9373 -486
GP1BA 6193 -281 -6485
GP1BB 7358 -785 -7237
GP5 1285 -7884 -3763
GP9 7394 -2598 -8439
KLKB1 -8711 -3785 -3895
SERPING1 -10849 -7006 10802
TPST1 9094 11280 -2442
TPST2 5652 8306 -5771
VWF 6550 -369 -8508



Diseases of hemostasis

Diseases of hemostasis
metric value
setSize 12
pMANOVA 0.00104
p.adjustMANOVA 0.00284
s.dist 0.61
s.t0_v_pod 0.478
s.pod_crp 0.0954
s.t0_crp -0.366
p.t0_v_pod 0.00412
p.pod_crp 0.567
p.t0_crp 0.028




Top 20 genes
Gene t0_v_pod t0_crp
F12 9331 -8919
GP9 7394 -8439
VWF 6550 -8508
GP1BB 7358 -7237
GP1BA 6193 -6485
TPST2 5652 -5771
TPST1 9094 -2442
GP5 1285 -3763
GGCX 5176 -486

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
F12 9331 11462 -8919
F8 6919 4727 5869
GGCX 5176 9373 -486
GP1BA 6193 -281 -6485
GP1BB 7358 -785 -7237
GP5 1285 -7884 -3763
GP9 7394 -2598 -8439
KLKB1 -8711 -3785 -3895
SERPING1 -10849 -7006 10802
TPST1 9094 11280 -2442
TPST2 5652 8306 -5771
VWF 6550 -369 -8508



Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
metric value
setSize 22
pMANOVA 1.98e-05
p.adjustMANOVA 9.28e-05
s.dist 0.61
s.t0_v_pod 0.471
s.pod_crp 0.183
s.t0_crp -0.341
p.t0_v_pod 0.000132
p.pod_crp 0.138
p.t0_crp 0.00558




Top 20 genes
Gene t0_v_pod t0_crp
H2BC12 8898.0 -8447.0
H2AJ 9214.0 -7261.0
H2BC17 7178.0 -8062.0
H2BC4 7279.0 -7646.0
H3C15 6608.5 -7756.5
H2AZ1 5955.0 -8479.0
H2BC21 9125.0 -5196.0
H2BC11 7791.0 -5526.0
H2BC9 5332.0 -6635.0
H2AC6 7813.0 -4205.0
H2BC5 7881.0 -2937.0
H2BC15 5251.0 -4235.0
AR 4784.0 -353.0

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AR 4784.0 4607.0 -353.0
H2AC20 4913.0 8671.0 3752.0
H2AC6 7813.0 -1814.0 -4205.0
H2AJ 9214.0 11405.0 -7261.0
H2AZ1 5955.0 2933.0 -8479.0
H2AZ2 -1192.0 -5862.0 -2370.0
H2BC11 7791.0 3262.0 -5526.0
H2BC12 8898.0 6037.0 -8447.0
H2BC15 5251.0 523.0 -4235.0
H2BC17 7178.0 3760.0 -8062.0
H2BC21 9125.0 6114.0 -5196.0
H2BC4 7279.0 4199.0 -7646.0
H2BC5 7881.0 4394.0 -2937.0
H2BC9 5332.0 -6224.0 -6635.0
H2BU1 -6332.0 -2185.0 2615.0
H3-3A 8519.0 7532.0 5003.0
H3C15 6608.5 6537.5 -7756.5
KDM1A -9114.0 -5943.0 2112.0
KDM4C -10406.0 -1912.0 2431.0
KLK2 3004.0 4886.0 3997.0
NCOA2 1083.0 4273.0 1379.0
PKN1 -2164.0 6449.0 -8275.0



HDR through MMEJ (alt-NHEJ)

HDR through MMEJ (alt-NHEJ)
metric value
setSize 10
pMANOVA 0.0515
p.adjustMANOVA 0.0826
s.dist 0.606
s.t0_v_pod -0.429
s.pod_crp -0.365
s.t0_crp 0.225
p.t0_v_pod 0.0188
p.pod_crp 0.0458
p.t0_crp 0.219




Top 20 genes
Gene t0_v_pod pod_crp
PARP1 -11409 -9090
FEN1 -10254 -7081
PARP2 -11860 -5348
MRE11 -7647 -4925
RAD50 -7119 -4034
LIG3 -10676 -1834

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
FEN1 -10254 -7081 -1614
LIG3 -10676 -1834 -1677
MRE11 -7647 -4925 2183
NBN 2254 707 10226
PARP1 -11409 -9090 -4667
PARP2 -11860 -5348 9470
POLQ 590 -5078 3819
RAD50 -7119 -4034 9994
RBBP8 -4935 5839 10842
XRCC1 1927 379 -8177



IRAK1 recruits IKK complex

IRAK1 recruits IKK complex
metric value
setSize 10
pMANOVA 0.0229
p.adjustMANOVA 0.0411
s.dist 0.605
s.t0_v_pod 0.533
s.pod_crp 0.263
s.t0_crp -0.114
p.t0_v_pod 0.00352
p.pod_crp 0.15
p.t0_crp 0.531




Top 20 genes
Gene t0_v_pod pod_crp
PELI3 7600 10850
CHUK 7844 7098
IKBKG 5315 8787
IRAK1 6047 7556
PELI2 8183 3231
PELI1 6623 1863

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CHUK 7844 7098 7094
IKBKB -5208 5101 -4279
IKBKG 5315 8787 -7863
IRAK1 6047 7556 -9167
PELI1 6623 1863 2111
PELI2 8183 3231 -194
PELI3 7600 10850 -9843
TRAF6 -229 -1341 2232
UBE2N 1923 -3127 8877
UBE2V1 5568 -3400 5229



IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
metric value
setSize 10
pMANOVA 0.0229
p.adjustMANOVA 0.0411
s.dist 0.605
s.t0_v_pod 0.533
s.pod_crp 0.263
s.t0_crp -0.114
p.t0_v_pod 0.00352
p.pod_crp 0.15
p.t0_crp 0.531




Top 20 genes
Gene t0_v_pod pod_crp
PELI3 7600 10850
CHUK 7844 7098
IKBKG 5315 8787
IRAK1 6047 7556
PELI2 8183 3231
PELI1 6623 1863

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CHUK 7844 7098 7094
IKBKB -5208 5101 -4279
IKBKG 5315 8787 -7863
IRAK1 6047 7556 -9167
PELI1 6623 1863 2111
PELI2 8183 3231 -194
PELI3 7600 10850 -9843
TRAF6 -229 -1341 2232
UBE2N 1923 -3127 8877
UBE2V1 5568 -3400 5229



MAP2K and MAPK activation

MAP2K and MAPK activation
metric value
setSize 34
pMANOVA 1.76e-06
p.adjustMANOVA 1.1e-05
s.dist 0.605
s.t0_v_pod 0.516
s.pod_crp 0.292
s.t0_crp -0.116
p.t0_v_pod 1.87e-07
p.pod_crp 0.00317
p.t0_crp 0.243




Top 20 genes
Gene t0_v_pod pod_crp
MARK3 8555 10797
ARRB2 8355 10835
MAP2K1 8910 10086
MAPK3 8803 9501
APBB1IP 8600 9624
MAPK1 7381 10667
RAF1 7759 9678
TLN1 8386 8793
IQGAP1 8024 8880
LAMTOR2 7454 9183
CSK 5158 10149
RAP1A 7198 6943
KSR1 4126 10936
MAP2K2 6699 5024
WDR83 3684 7447
RAP1B 3179 5307
ITGA2B 8744 1914
LAMTOR3 7461 2039
ARAF 2624 5660
YWHAB 6298 2024

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
APBB1IP 8600 9624 5781
ARAF 2624 5660 -6907
ARRB1 1985 5802 -8113
ARRB2 8355 10835 -5123
BRAF 1298 420 2465
CNKSR1 -6846 -6452 2350
CNKSR2 -4628 -2235 571
CSK 5158 10149 -6693
FN1 8154 -1733 4890
HRAS -3288 -3089 -7583
IQGAP1 8024 8880 -22
ITGA2B 8744 1914 -6113
ITGB3 8161 -2845 -6419
KRAS 3668 3086 11151
KSR1 4126 10936 6008
KSR2 -3268 -1010 -3271
LAMTOR2 7454 9183 -8579
LAMTOR3 7461 2039 8800
MAP2K1 8910 10086 -3295
MAP2K2 6699 5024 -9806
MAPK1 7381 10667 -1770
MAPK3 8803 9501 -9768
MARK3 8555 10797 10115
NRAS 5302 1813 9977
PEBP1 -10920 -9535 472
RAF1 7759 9678 1415
RAP1A 7198 6943 11289
RAP1B 3179 5307 7206
SRC -8520 -5490 -4085
TLN1 8386 8793 -7844
VCL 7218 1206 -2715
VWF 6550 -369 -8508
WDR83 3684 7447 -6739
YWHAB 6298 2024 10696



Cargo concentration in the ER

Cargo concentration in the ER
metric value
setSize 30
pMANOVA 7.4e-06
p.adjustMANOVA 3.97e-05
s.dist 0.603
s.t0_v_pod 0.52
s.pod_crp 0.283
s.t0_crp 0.114
p.t0_v_pod 8.05e-07
p.pod_crp 0.00723
p.t0_crp 0.28




Top 20 genes
Gene t0_v_pod pod_crp
F5 9324 11415
SERPINA1 9013 11480
CTSZ 8825 10594
TGFA 8740 9788
SEC24D 7988 10178
PREB 6281 10138
COL7A1 6218 10019
LMAN2 6976 8815
STX5 7060 7972
SEC24A 7544 6850
F8 6919 4727
SAR1B 6391 4503
MIA2 5506 4261
CTSC 2312 9392
SEC24B 3576 4369
SEC23A 7225 1825
SEC22B 5797 2151
LMAN2L 6837 1659
TMED2 5971 962
AREG 5897 929

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
AREG 5897 929 -8132
CD59 5783 -3188 -3930
CNIH1 7662 -3128 -2674
CNIH2 648 6266 -214
CNIH3 -8703 -6297 -8895
COL7A1 6218 10019 -8651
CTSC 2312 9392 5785
CTSZ 8825 10594 -2796
F5 9324 11415 4201
F8 6919 4727 5869
GOSR2 -1435 2674 7258
LMAN1 -10289 -8956 10044
LMAN2 6976 8815 -4647
LMAN2L 6837 1659 -8532
MCFD2 6995 658 -1540
MIA2 5506 4261 11119
MIA3 -6036 -3950 8910
PREB 6281 10138 447
SAR1B 6391 4503 11213
SEC22B 5797 2151 10635
SEC23A 7225 1825 6295
SEC24A 7544 6850 6438
SEC24B 3576 4369 8674
SEC24C -2506 6986 -4040
SEC24D 7988 10178 7102
SERPINA1 9013 11480 6681
STX5 7060 7972 -6393
TGFA 8740 9788 -4955
TMED10 321 -6827 1421
TMED2 5971 962 8999



Budding and maturation of HIV virion

Budding and maturation of HIV virion
metric value
setSize 26
pMANOVA 4.06e-05
p.adjustMANOVA 0.000167
s.dist 0.602
s.t0_v_pod 0.525
s.pod_crp 0.284
s.t0_crp -0.078
p.t0_v_pod 3.5e-06
p.pod_crp 0.0123
p.t0_crp 0.491




Top 20 genes
Gene t0_v_pod pod_crp
CHMP4B 8718 10453
CHMP2A 8635 10454
VPS37C 7888 10622
UBAP1 8559 9210
NEDD4L 7755 9200
MVB12A 7290 9558
CHMP3 8217 6631
PDCD6IP 6440 8445
CHMP5 4886 9534
TSG101 7669 5568
MVB12B 5115 7206
VPS37A 6379 5671
CHMP6 5434 6618
VPS37B 3869 6452
UBC 4395 4824
CHMP4A 2384 6615
VTA1 6101 1750
VPS28 4156 891

Click HERE to show all gene set members

All member genes
t0_v_pod pod_crp t0_crp
CHMP2A 8635 10454 -4083
CHMP2B 5641 -387 10468
CHMP3 8217 6631 2895
CHMP4A 2384 6615 5051
CHMP4B 8718 10453 -6190
CHMP5 4886 9534 10758
CHMP6 5434 6618 -8771
CHMP7 -8503 -9356 -2659
MVB12A 7290 9558 -8589
MVB12B 5115 7206 3878
NEDD4L 7755 9200 -5302
PDCD6IP 6440 8445 11228
PPIA -6535 -4528 -557
RPS27A -6700 -8679 -8103
TSG101 7669 5568 9432
UBA52 1112 -1425 -7104
UBAP1 8559 9210 -1245
UBB 6548 -2419 -4745
UBC 4395 4824 -4004
VPS28 4156 891 -8254
VPS37A 6379 5671 10596
VPS37B 3869 6452 -8735
VPS37C 7888 10622 687
VPS4A 777 -1430 -9586
VPS4B 5151 -624 7717
VTA1 6101 1750 10229



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0               GGally_2.1.1               
##  [3] beeswarm_0.3.1              gtools_3.8.2               
##  [5] echarts4r_0.4.0             topconfects_1.6.0          
##  [7] limma_3.46.0                eulerr_6.1.0               
##  [9] mitch_1.2.2                 MASS_7.3-53.1              
## [11] fgsea_1.16.0                gplots_3.1.1               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.58.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] reshape2_1.4.4              forcats_0.5.1              
## [25] stringr_1.4.0               dplyr_1.0.5                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.3                 tibble_3.1.0               
## [31] ggplot2_3.3.3               tidyverse_1.3.0            
## [33] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_2.0.2       
##   [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.13       
##   [7] farver_2.1.0           bit64_4.0.5            AnnotationDbi_1.52.0  
##  [10] fansi_0.4.2            lubridate_1.7.10       xml2_1.3.2            
##  [13] splines_4.0.3          cachem_1.0.4           geneplotter_1.68.0    
##  [16] knitr_1.31             polyclip_1.10-0        jsonlite_1.7.2        
##  [19] broom_0.7.5            annotate_1.68.0        dbplyr_2.1.0          
##  [22] shiny_1.6.0            compiler_4.0.3         httr_1.4.2            
##  [25] backports_1.2.1        assertthat_0.2.1       Matrix_1.3-2          
##  [28] fastmap_1.1.0          cli_2.3.1              later_1.1.0.1         
##  [31] htmltools_0.5.1.1      tools_4.0.3            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
##  [37] Rcpp_1.0.6             cellranger_1.1.0       jquerylib_0.1.3       
##  [40] vctrs_0.3.6            polylabelr_0.2.0       xfun_0.22             
##  [43] ps_1.6.0               testthat_3.0.2         rvest_1.0.0           
##  [46] mime_0.10              lifecycle_1.0.0        XML_3.99-0.6          
##  [49] zlibbioc_1.36.0        scales_1.1.1           promises_1.2.0.1      
##  [52] hms_1.0.0              RColorBrewer_1.1-2     yaml_2.2.1            
##  [55] memoise_2.0.0          gridExtra_2.3          sass_0.3.1            
##  [58] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.4         
##  [61] highr_0.8              genefilter_1.72.0      desc_1.3.0            
##  [64] caTools_1.18.1         BiocParallel_1.24.1    rlang_0.4.10          
##  [67] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
##  [70] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.3     
##  [73] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
##  [76] magrittr_2.0.1         R6_2.5.0               generics_0.1.0        
##  [79] DelayedArray_0.16.0    DBI_1.1.1              pillar_1.5.1          
##  [82] haven_2.3.1            withr_2.4.1            survival_3.2-10       
##  [85] RCurl_1.98-1.3         modelr_0.1.8           crayon_1.4.1          
##  [88] KernSmooth_2.23-18     utf8_1.2.1             rmarkdown_2.7         
##  [91] locfit_1.5-9.4         grid_4.0.3             readxl_1.3.1          
##  [94] data.table_1.14.0      blob_1.2.1             reprex_1.0.0          
##  [97] digest_0.6.27          xtable_1.8-4           httpuv_1.5.5          
## [100] munsell_0.5.0          bslib_0.2.4

END of report