date generated: 2021-04-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                    x
## A1BG      0.23019048
## A1BG-AS1  0.62211022
## A1CF      0.68373998
## A2M      -0.03980079
## A2M-AS1  -0.04056761
## A2ML1     0.91485083

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2408
num_genes_in_profile 21631
duplicated_genes_present 0
num_profile_genes_in_sets 8410
num_profile_genes_not_in_sets 13221

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1045
num_genesets_included 1363

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 100 gene sets

set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 6.62e-06 0.823 1.14e-04
MyD88 deficiency (TLR2/4) 10 6.62e-06 0.823 1.14e-04
Peptide chain elongation 88 2.46e-30 -0.705 3.72e-28
Eukaryotic Translation Elongation 93 7.89e-32 -0.703 1.34e-29
Selenocysteine synthesis 92 9.58e-30 -0.682 1.10e-27
Viral mRNA Translation 88 1.67e-28 -0.682 1.62e-26
Formation of a pool of free 40S subunits 100 5.67e-32 -0.680 1.10e-29
Eukaryotic Translation Termination 92 2.59e-29 -0.677 2.72e-27
Translocation of ZAP-70 to Immunological synapse 24 1.86e-08 -0.663 5.90e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 3.69e-28 -0.656 3.35e-26
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.31e-04 0.637 1.52e-03
alpha-linolenic acid (ALA) metabolism 12 1.31e-04 0.637 1.52e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 9.21e-28 -0.631 6.61e-26
L13a-mediated translational silencing of Ceruloplasmin expression 110 9.65e-30 -0.624 1.10e-27
Regulation of TLR by endogenous ligand 11 3.45e-04 0.623 3.13e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 111 8.89e-30 -0.622 1.10e-27
Unwinding of DNA 12 2.11e-04 -0.618 2.15e-03
Formation of the ternary complex, and subsequently, the 43S complex 51 2.80e-14 -0.615 1.31e-12
Major pathway of rRNA processing in the nucleolus and cytosol 180 3.41e-43 -0.594 1.16e-40
rRNA processing in the nucleus and cytosol 190 6.06e-45 -0.590 8.26e-42
Cap-dependent Translation Initiation 118 5.14e-28 -0.584 3.89e-26
Eukaryotic Translation Initiation 118 5.14e-28 -0.584 3.89e-26
Activation of the pre-replicative complex 32 1.20e-08 -0.582 3.89e-07
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.04e-03 0.571 7.86e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.01e-25 -0.568 5.96e-24
Nonsense-Mediated Decay (NMD) 114 1.01e-25 -0.568 5.96e-24
SRP-dependent cotranslational protein targeting to membrane 111 1.26e-24 -0.562 6.59e-23
rRNA modification in the nucleus and cytosol 59 1.02e-13 -0.560 4.48e-12
Selenoamino acid metabolism 114 1.10e-24 -0.555 6.01e-23
rRNA processing 217 4.38e-44 -0.547 2.99e-41
Influenza Viral RNA Transcription and Replication 135 4.19e-28 -0.547 3.57e-26
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.84e-03 0.545 1.73e-02
Translation initiation complex formation 58 6.84e-13 -0.545 2.91e-11
Ribosomal scanning and start codon recognition 58 1.10e-12 -0.540 4.39e-11
DNA strand elongation 32 1.35e-07 -0.538 3.40e-06
Hyaluronan uptake and degradation 12 1.32e-03 0.535 9.29e-03
Heme degradation 10 3.64e-03 0.531 2.12e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.07e-12 -0.529 8.07e-11
PD-1 signaling 28 1.37e-06 -0.527 2.92e-05
VLDLR internalisation and degradation 12 1.78e-03 0.521 1.16e-02
Telomere C-strand synthesis initiation 13 1.36e-03 -0.513 9.36e-03
Nucleobase biosynthesis 13 1.45e-03 -0.510 9.89e-03
MET activates RAP1 and RAC1 10 5.25e-03 0.510 2.86e-02
Influenza Infection 154 5.85e-27 -0.501 3.80e-25
Processive synthesis on the lagging strand 15 9.07e-04 -0.495 7.11e-03
Activation of ATR in response to replication stress 37 1.91e-07 -0.495 4.72e-06
Lagging Strand Synthesis 20 1.47e-04 -0.490 1.67e-03
Telomere C-strand (Lagging Strand) Synthesis 34 7.85e-07 -0.489 1.81e-05
RHO GTPases Activate ROCKs 18 3.59e-04 0.486 3.18e-03
Phosphorylation of CD3 and TCR zeta chains 27 1.96e-05 -0.475 2.96e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 6.05e-05 -0.473 8.09e-04
Removal of the Flap Intermediate 14 2.48e-03 -0.467 1.57e-02
PCNA-Dependent Long Patch Base Excision Repair 21 2.29e-04 -0.464 2.29e-03
BBSome-mediated cargo-targeting to cilium 22 1.90e-04 -0.460 2.02e-03
Generation of second messenger molecules 38 1.37e-06 -0.453 2.92e-05
Advanced glycosylation endproduct receptor signaling 12 6.76e-03 0.451 3.51e-02
Gap junction trafficking 13 4.93e-03 0.450 2.71e-02
Purine ribonucleoside monophosphate biosynthesis 10 1.39e-02 -0.449 5.99e-02
Early Phase of HIV Life Cycle 14 3.92e-03 -0.445 2.25e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.07e-02 -0.445 4.95e-02
Establishment of Sister Chromatid Cohesion 11 1.10e-02 -0.443 5.06e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.06e-03 0.442 1.84e-02
Postmitotic nuclear pore complex (NPC) reformation 27 7.16e-05 -0.441 9.10e-04
Interactions of Vpr with host cellular proteins 37 3.55e-06 -0.440 6.81e-05
Diseases associated with the TLR signaling cascade 23 2.81e-04 0.437 2.63e-03
Diseases of Immune System 23 2.81e-04 0.437 2.63e-03
CD22 mediated BCR regulation 59 6.94e-09 -0.436 2.31e-07
SLBP independent Processing of Histone Pre-mRNAs 10 1.70e-02 -0.436 7.04e-02
Translesion synthesis by REV1 16 2.58e-03 -0.435 1.61e-02
Interactions of Rev with host cellular proteins 37 4.77e-06 -0.435 8.66e-05
Dissolution of Fibrin Clot 12 9.70e-03 0.431 4.64e-02
Extension of Telomeres 51 1.09e-07 -0.430 2.87e-06
Vpr-mediated nuclear import of PICs 34 1.50e-05 -0.429 2.32e-04
Rev-mediated nuclear export of HIV RNA 35 1.17e-05 -0.428 1.93e-04
Uptake and function of anthrax toxins 10 1.92e-02 0.428 7.56e-02
Detoxification of Reactive Oxygen Species 32 3.05e-05 0.426 4.33e-04
G1/S-Specific Transcription 29 7.21e-05 -0.426 9.10e-04
Signal transduction by L1 20 1.01e-03 0.424 7.72e-03
RHO GTPases Activate NADPH Oxidases 21 8.13e-04 0.422 6.60e-03
Metabolism of non-coding RNA 53 1.11e-07 -0.421 2.87e-06
snRNP Assembly 53 1.11e-07 -0.421 2.87e-06
Transcription of E2F targets under negative control by DREAM complex 19 1.51e-03 -0.420 1.02e-02
WNT5A-dependent internalization of FZD4 13 8.74e-03 0.420 4.34e-02
RHO GTPases Activate WASPs and WAVEs 35 2.11e-05 0.415 3.16e-04
Polymerase switching on the C-strand of the telomere 26 2.49e-04 -0.415 2.45e-03
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.72e-02 0.415 7.07e-02
Nuclear import of Rev protein 34 2.89e-05 -0.414 4.14e-04
Platelet sensitization by LDL 16 4.20e-03 0.413 2.36e-02
NEP/NS2 Interacts with the Cellular Export Machinery 32 6.13e-05 -0.409 8.11e-04
Hyaluronan metabolism 15 6.74e-03 0.404 3.51e-02
Translesion synthesis by POLI 17 4.41e-03 -0.399 2.48e-02
Translation 295 4.36e-32 -0.398 9.91e-30
Processive synthesis on the C-strand of the telomere 19 2.78e-03 -0.396 1.70e-02
Pre-NOTCH Processing in Golgi 18 3.81e-03 0.394 2.20e-02
G0 and Early G1 27 4.38e-04 -0.391 3.78e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.50e-02 0.390 6.35e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.46e-04 -0.388 1.67e-03
Classical antibody-mediated complement activation 69 2.98e-08 -0.386 9.02e-07
Scavenging of heme from plasma 71 2.01e-08 -0.385 6.23e-07
Leading Strand Synthesis 14 1.26e-02 -0.385 5.58e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
IRAK4 deficiency (TLR2/4) 10 6.62e-06 8.23e-01 1.14e-04
MyD88 deficiency (TLR2/4) 10 6.62e-06 8.23e-01 1.14e-04
Peptide chain elongation 88 2.46e-30 -7.05e-01 3.72e-28
Eukaryotic Translation Elongation 93 7.89e-32 -7.03e-01 1.34e-29
Selenocysteine synthesis 92 9.58e-30 -6.82e-01 1.10e-27
Viral mRNA Translation 88 1.67e-28 -6.82e-01 1.62e-26
Formation of a pool of free 40S subunits 100 5.67e-32 -6.80e-01 1.10e-29
Eukaryotic Translation Termination 92 2.59e-29 -6.77e-01 2.72e-27
Translocation of ZAP-70 to Immunological synapse 24 1.86e-08 -6.63e-01 5.90e-07
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 3.69e-28 -6.56e-01 3.35e-26
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.31e-04 6.37e-01 1.52e-03
alpha-linolenic acid (ALA) metabolism 12 1.31e-04 6.37e-01 1.52e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 9.21e-28 -6.31e-01 6.61e-26
L13a-mediated translational silencing of Ceruloplasmin expression 110 9.65e-30 -6.24e-01 1.10e-27
Regulation of TLR by endogenous ligand 11 3.45e-04 6.23e-01 3.13e-03
GTP hydrolysis and joining of the 60S ribosomal subunit 111 8.89e-30 -6.22e-01 1.10e-27
Unwinding of DNA 12 2.11e-04 -6.18e-01 2.15e-03
Formation of the ternary complex, and subsequently, the 43S complex 51 2.80e-14 -6.15e-01 1.31e-12
Major pathway of rRNA processing in the nucleolus and cytosol 180 3.41e-43 -5.94e-01 1.16e-40
rRNA processing in the nucleus and cytosol 190 6.06e-45 -5.90e-01 8.26e-42
Cap-dependent Translation Initiation 118 5.14e-28 -5.84e-01 3.89e-26
Eukaryotic Translation Initiation 118 5.14e-28 -5.84e-01 3.89e-26
Activation of the pre-replicative complex 32 1.20e-08 -5.82e-01 3.89e-07
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.04e-03 5.71e-01 7.86e-03
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.01e-25 -5.68e-01 5.96e-24
Nonsense-Mediated Decay (NMD) 114 1.01e-25 -5.68e-01 5.96e-24
SRP-dependent cotranslational protein targeting to membrane 111 1.26e-24 -5.62e-01 6.59e-23
rRNA modification in the nucleus and cytosol 59 1.02e-13 -5.60e-01 4.48e-12
Selenoamino acid metabolism 114 1.10e-24 -5.55e-01 6.01e-23
rRNA processing 217 4.38e-44 -5.47e-01 2.99e-41
Influenza Viral RNA Transcription and Replication 135 4.19e-28 -5.47e-01 3.57e-26
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 2.84e-03 5.45e-01 1.73e-02
Translation initiation complex formation 58 6.84e-13 -5.45e-01 2.91e-11
Ribosomal scanning and start codon recognition 58 1.10e-12 -5.40e-01 4.39e-11
DNA strand elongation 32 1.35e-07 -5.38e-01 3.40e-06
Hyaluronan uptake and degradation 12 1.32e-03 5.35e-01 9.29e-03
Heme degradation 10 3.64e-03 5.31e-01 2.12e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.07e-12 -5.29e-01 8.07e-11
PD-1 signaling 28 1.37e-06 -5.27e-01 2.92e-05
VLDLR internalisation and degradation 12 1.78e-03 5.21e-01 1.16e-02
Telomere C-strand synthesis initiation 13 1.36e-03 -5.13e-01 9.36e-03
Nucleobase biosynthesis 13 1.45e-03 -5.10e-01 9.89e-03
MET activates RAP1 and RAC1 10 5.25e-03 5.10e-01 2.86e-02
Influenza Infection 154 5.85e-27 -5.01e-01 3.80e-25
Processive synthesis on the lagging strand 15 9.07e-04 -4.95e-01 7.11e-03
Activation of ATR in response to replication stress 37 1.91e-07 -4.95e-01 4.72e-06
Lagging Strand Synthesis 20 1.47e-04 -4.90e-01 1.67e-03
Telomere C-strand (Lagging Strand) Synthesis 34 7.85e-07 -4.89e-01 1.81e-05
RHO GTPases Activate ROCKs 18 3.59e-04 4.86e-01 3.18e-03
Phosphorylation of CD3 and TCR zeta chains 27 1.96e-05 -4.75e-01 2.96e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 6.05e-05 -4.73e-01 8.09e-04
Removal of the Flap Intermediate 14 2.48e-03 -4.67e-01 1.57e-02
PCNA-Dependent Long Patch Base Excision Repair 21 2.29e-04 -4.64e-01 2.29e-03
BBSome-mediated cargo-targeting to cilium 22 1.90e-04 -4.60e-01 2.02e-03
Generation of second messenger molecules 38 1.37e-06 -4.53e-01 2.92e-05
Advanced glycosylation endproduct receptor signaling 12 6.76e-03 4.51e-01 3.51e-02
Gap junction trafficking 13 4.93e-03 4.50e-01 2.71e-02
Purine ribonucleoside monophosphate biosynthesis 10 1.39e-02 -4.49e-01 5.99e-02
Early Phase of HIV Life Cycle 14 3.92e-03 -4.45e-01 2.25e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 1.07e-02 -4.45e-01 4.95e-02
Establishment of Sister Chromatid Cohesion 11 1.10e-02 -4.43e-01 5.06e-02
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 3.06e-03 4.42e-01 1.84e-02
Postmitotic nuclear pore complex (NPC) reformation 27 7.16e-05 -4.41e-01 9.10e-04
Interactions of Vpr with host cellular proteins 37 3.55e-06 -4.40e-01 6.81e-05
Diseases associated with the TLR signaling cascade 23 2.81e-04 4.37e-01 2.63e-03
Diseases of Immune System 23 2.81e-04 4.37e-01 2.63e-03
CD22 mediated BCR regulation 59 6.94e-09 -4.36e-01 2.31e-07
SLBP independent Processing of Histone Pre-mRNAs 10 1.70e-02 -4.36e-01 7.04e-02
Translesion synthesis by REV1 16 2.58e-03 -4.35e-01 1.61e-02
Interactions of Rev with host cellular proteins 37 4.77e-06 -4.35e-01 8.66e-05
Dissolution of Fibrin Clot 12 9.70e-03 4.31e-01 4.64e-02
Extension of Telomeres 51 1.09e-07 -4.30e-01 2.87e-06
Vpr-mediated nuclear import of PICs 34 1.50e-05 -4.29e-01 2.32e-04
Rev-mediated nuclear export of HIV RNA 35 1.17e-05 -4.28e-01 1.93e-04
Uptake and function of anthrax toxins 10 1.92e-02 4.28e-01 7.56e-02
Detoxification of Reactive Oxygen Species 32 3.05e-05 4.26e-01 4.33e-04
G1/S-Specific Transcription 29 7.21e-05 -4.26e-01 9.10e-04
Signal transduction by L1 20 1.01e-03 4.24e-01 7.72e-03
RHO GTPases Activate NADPH Oxidases 21 8.13e-04 4.22e-01 6.60e-03
Metabolism of non-coding RNA 53 1.11e-07 -4.21e-01 2.87e-06
snRNP Assembly 53 1.11e-07 -4.21e-01 2.87e-06
Transcription of E2F targets under negative control by DREAM complex 19 1.51e-03 -4.20e-01 1.02e-02
WNT5A-dependent internalization of FZD4 13 8.74e-03 4.20e-01 4.34e-02
RHO GTPases Activate WASPs and WAVEs 35 2.11e-05 4.15e-01 3.16e-04
Polymerase switching on the C-strand of the telomere 26 2.49e-04 -4.15e-01 2.45e-03
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.72e-02 4.15e-01 7.07e-02
Nuclear import of Rev protein 34 2.89e-05 -4.14e-01 4.14e-04
Platelet sensitization by LDL 16 4.20e-03 4.13e-01 2.36e-02
NEP/NS2 Interacts with the Cellular Export Machinery 32 6.13e-05 -4.09e-01 8.11e-04
Hyaluronan metabolism 15 6.74e-03 4.04e-01 3.51e-02
Translesion synthesis by POLI 17 4.41e-03 -3.99e-01 2.48e-02
Translation 295 4.36e-32 -3.98e-01 9.91e-30
Processive synthesis on the C-strand of the telomere 19 2.78e-03 -3.96e-01 1.70e-02
Pre-NOTCH Processing in Golgi 18 3.81e-03 3.94e-01 2.20e-02
G0 and Early G1 27 4.38e-04 -3.91e-01 3.78e-03
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 1.50e-02 3.90e-01 6.35e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.46e-04 -3.88e-01 1.67e-03
Classical antibody-mediated complement activation 69 2.98e-08 -3.86e-01 9.02e-07
Scavenging of heme from plasma 71 2.01e-08 -3.85e-01 6.23e-07
Leading Strand Synthesis 14 1.26e-02 -3.85e-01 5.58e-02
Polymerase switching 14 1.26e-02 -3.85e-01 5.58e-02
Folding of actin by CCT/TriC 10 3.57e-02 -3.83e-01 1.22e-01
EPHB-mediated forward signaling 32 1.83e-04 3.82e-01 1.97e-03
Export of Viral Ribonucleoproteins from Nucleus 33 1.53e-04 -3.81e-01 1.71e-03
Erythropoietin activates RAS 13 1.76e-02 3.80e-01 7.10e-02
NS1 Mediated Effects on Host Pathways 40 3.22e-05 -3.80e-01 4.48e-04
Insulin receptor recycling 21 2.60e-03 3.80e-01 1.61e-02
Recognition of DNA damage by PCNA-containing replication complex 30 3.61e-04 -3.76e-01 3.18e-03
Translesion synthesis by POLK 17 7.28e-03 -3.76e-01 3.75e-02
Neutrophil degranulation 457 3.04e-43 3.76e-01 1.16e-40
Gap junction trafficking and regulation 15 1.19e-02 3.75e-01 5.38e-02
Mitochondrial tRNA aminoacylation 21 3.09e-03 -3.73e-01 1.84e-02
Retrograde neurotrophin signalling 12 2.53e-02 3.73e-01 9.40e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.62e-02 -3.71e-01 6.81e-02
Diseases of DNA repair 10 4.27e-02 -3.70e-01 1.39e-01
HDR through MMEJ (alt-NHEJ) 10 4.30e-02 -3.70e-01 1.39e-01
Mucopolysaccharidoses 11 3.41e-02 3.69e-01 1.17e-01
Mismatch Repair 15 1.39e-02 -3.67e-01 5.99e-02
Creation of C4 and C2 activators 71 9.77e-08 -3.66e-01 2.66e-06
mRNA decay by 3’ to 5’ exoribonuclease 16 1.16e-02 -3.65e-01 5.26e-02
Collagen degradation 29 6.92e-04 3.64e-01 5.72e-03
ROS and RNS production in phagocytes 31 4.58e-04 3.64e-01 3.92e-03
Transferrin endocytosis and recycling 26 1.35e-03 3.63e-01 9.36e-03
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 1.19e-02 -3.63e-01 5.38e-02
RHO GTPases activate IQGAPs 11 3.73e-02 3.63e-01 1.25e-01
Transport of the SLBP Dependant Mature mRNA 36 1.67e-04 -3.63e-01 1.83e-03
Removal of the Flap Intermediate from the C-strand 17 9.82e-03 -3.62e-01 4.67e-02
FCGR activation 76 5.44e-08 -3.61e-01 1.54e-06
Regulation of FZD by ubiquitination 15 1.62e-02 -3.59e-01 6.81e-02
tRNA processing in the nucleus 59 1.89e-06 -3.59e-01 3.90e-05
Transport of the SLBP independent Mature mRNA 35 2.50e-04 -3.58e-01 2.45e-03
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 2.12e-02 -3.56e-01 8.19e-02
Regulation of expression of SLITs and ROBOs 159 3.68e-14 -3.48e-01 1.67e-12
Regulated proteolysis of p75NTR 11 4.82e-02 3.44e-01 1.50e-01
Nuclear Pore Complex (NPC) Disassembly 36 3.64e-04 -3.43e-01 3.18e-03
Dectin-2 family 19 9.69e-03 3.43e-01 4.64e-02
Translesion Synthesis by POLH 18 1.20e-02 -3.42e-01 5.38e-02
Role of LAT2/NTAL/LAB on calcium mobilization 74 4.04e-07 -3.41e-01 9.84e-06
Chemokine receptors bind chemokines 37 3.40e-04 -3.40e-01 3.11e-03
Sema4D in semaphorin signaling 22 5.95e-03 3.39e-01 3.17e-02
E2F mediated regulation of DNA replication 22 6.37e-03 -3.36e-01 3.35e-02
COPI-independent Golgi-to-ER retrograde traffic 33 8.51e-04 3.35e-01 6.83e-03
Pentose phosphate pathway 13 3.65e-02 3.35e-01 1.23e-01
LDL clearance 18 1.41e-02 3.34e-01 6.02e-02
GPVI-mediated activation cascade 31 1.28e-03 3.34e-01 9.13e-03
tRNA modification in the nucleus and cytosol 43 1.52e-04 -3.34e-01 1.71e-03
Gap-filling DNA repair synthesis and ligation in GG-NER 25 3.92e-03 -3.33e-01 2.25e-02
FCERI mediated Ca+2 mobilization 89 5.89e-08 -3.32e-01 1.64e-06
Resolution of Abasic Sites (AP sites) 37 4.98e-04 -3.31e-01 4.21e-03
SUMOylation of SUMOylation proteins 35 8.23e-04 -3.27e-01 6.64e-03
tRNA Aminoacylation 42 2.63e-04 -3.25e-01 2.53e-03
Lysosome Vesicle Biogenesis 32 1.50e-03 3.24e-01 1.02e-02
Regulation of IFNG signaling 14 3.59e-02 3.24e-01 1.22e-01
Signaling by Erythropoietin 24 6.10e-03 3.23e-01 3.24e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 32 1.56e-03 -3.23e-01 1.04e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 32 1.56e-03 -3.23e-01 1.04e-02
Sema4D induced cell migration and growth-cone collapse 19 1.51e-02 3.22e-01 6.40e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 6.60e-02 3.20e-01 1.86e-01
Metabolism of amine-derived hormones 10 8.09e-02 -3.19e-01 2.17e-01
Long-term potentiation 14 3.91e-02 -3.18e-01 1.29e-01
Glutamate and glutamine metabolism 12 5.61e-02 -3.18e-01 1.67e-01
Post-translational protein phosphorylation 70 4.10e-06 3.18e-01 7.55e-05
Transcriptional Regulation by E2F6 34 1.36e-03 -3.17e-01 9.36e-03
RNA Polymerase I Transcription Initiation 44 2.78e-04 -3.17e-01 2.63e-03
Chondroitin sulfate biosynthesis 12 5.78e-02 3.16e-01 1.71e-01
Growth hormone receptor signaling 20 1.44e-02 3.16e-01 6.14e-02
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.43e-02 3.10e-01 1.42e-01
Initial triggering of complement 78 2.23e-06 -3.10e-01 4.48e-05
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 9.73e-07 -3.09e-01 2.21e-05
RHO GTPases activate CIT 18 2.35e-02 3.08e-01 8.86e-02
SUMOylation of RNA binding proteins 47 2.56e-04 -3.08e-01 2.49e-03
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 2.85e-02 -3.07e-01 1.03e-01
Telomere Extension By Telomerase 23 1.10e-02 -3.06e-01 5.05e-02
Negative regulation of MET activity 18 2.51e-02 3.05e-01 9.36e-02
tRNA processing 134 1.13e-09 -3.05e-01 4.06e-08
Termination of translesion DNA synthesis 32 2.87e-03 -3.05e-01 1.74e-02
Scavenging by Class A Receptors 11 8.08e-02 3.04e-01 2.17e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 20 1.90e-02 -3.03e-01 7.52e-02
Role of phospholipids in phagocytosis 88 1.17e-06 -3.00e-01 2.61e-05
PINK1-PRKN Mediated Mitophagy 21 1.79e-02 -2.98e-01 7.19e-02
Prolonged ERK activation events 13 6.27e-02 2.98e-01 1.79e-01
Recycling pathway of L1 26 8.55e-03 2.98e-01 4.27e-02
Intraflagellar transport 39 1.35e-03 -2.97e-01 9.36e-03
Regulation of IFNA signaling 12 7.55e-02 2.96e-01 2.06e-01
trans-Golgi Network Vesicle Budding 69 2.39e-05 2.94e-01 3.53e-04
Plasma lipoprotein assembly 10 1.08e-01 2.93e-01 2.70e-01
CLEC7A (Dectin-1) induces NFAT activation 11 9.23e-02 -2.93e-01 2.41e-01
AKT phosphorylates targets in the cytosol 14 5.85e-02 2.92e-01 1.73e-01
Metabolism of RNA 685 1.57e-38 -2.90e-01 4.27e-36
RNA Polymerase III Chain Elongation 18 3.37e-02 -2.89e-01 1.17e-01
Gluconeogenesis 28 8.23e-03 2.88e-01 4.16e-02
Signal regulatory protein family interactions 12 8.43e-02 2.88e-01 2.24e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.11e-03 -2.87e-01 8.30e-03
MAP2K and MAPK activation 34 3.74e-03 2.87e-01 2.17e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 7.90e-03 2.85e-01 4.02e-02
Notch-HLH transcription pathway 28 9.05e-03 2.85e-01 4.45e-02
EPH-Ephrin signaling 79 1.22e-05 2.85e-01 1.96e-04
ERKs are inactivated 13 7.64e-02 2.84e-01 2.08e-01
SUMOylation of immune response proteins 11 1.03e-01 2.84e-01 2.63e-01
Biotin transport and metabolism 11 1.03e-01 -2.84e-01 2.63e-01
Chromosome Maintenance 105 5.23e-07 -2.83e-01 1.25e-05
Activation of Matrix Metalloproteinases 23 1.90e-02 2.82e-01 7.52e-02
Beta-oxidation of very long chain fatty acids 10 1.22e-01 2.82e-01 2.96e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.59e-03 -2.82e-01 1.05e-02
The NLRP3 inflammasome 15 6.05e-02 2.80e-01 1.74e-01
SUMOylation of DNA replication proteins 46 1.05e-03 -2.79e-01 7.91e-03
Budding and maturation of HIV virion 26 1.40e-02 2.78e-01 6.02e-02
G-protein beta:gamma signalling 29 9.51e-03 2.78e-01 4.60e-02
Cargo concentration in the ER 30 8.37e-03 2.78e-01 4.21e-02
SUMOylation of chromatin organization proteins 57 2.89e-04 -2.78e-01 2.68e-03
Regulation of TP53 Activity through Acetylation 29 1.00e-02 -2.76e-01 4.72e-02
RHO GTPases activate KTN1 11 1.13e-01 2.76e-01 2.80e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.15e-02 -2.76e-01 5.25e-02
Mitochondrial translation elongation 91 6.17e-06 -2.74e-01 1.09e-04
Cytosolic tRNA aminoacylation 24 2.01e-02 -2.74e-01 7.81e-02
Cohesin Loading onto Chromatin 10 1.33e-01 -2.74e-01 3.17e-01
Trafficking of GluR2-containing AMPA receptors 12 1.01e-01 2.74e-01 2.57e-01
Homologous DNA Pairing and Strand Exchange 42 2.17e-03 -2.73e-01 1.38e-02
Defects in vitamin and cofactor metabolism 21 3.04e-02 -2.73e-01 1.07e-01
COPI-mediated anterograde transport 78 3.17e-05 2.72e-01 4.45e-04
TNFs bind their physiological receptors 25 1.88e-02 -2.71e-01 7.50e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 81 2.53e-05 2.71e-01 3.71e-04
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 7.14e-05 -2.71e-01 9.10e-04
Plasma lipoprotein remodeling 18 4.68e-02 2.71e-01 1.47e-01
Dual Incision in GG-NER 41 2.71e-03 -2.71e-01 1.67e-02
FCGR3A-mediated IL10 synthesis 99 3.84e-06 -2.69e-01 7.27e-05
VxPx cargo-targeting to cilium 19 4.27e-02 2.69e-01 1.39e-01
Binding and Uptake of Ligands by Scavenger Receptors 92 8.56e-06 -2.68e-01 1.44e-04
Signaling by Leptin 10 1.42e-01 2.68e-01 3.30e-01
Plasma lipoprotein assembly, remodeling, and clearance 53 7.36e-04 2.68e-01 6.04e-03
Deadenylation-dependent mRNA decay 53 7.55e-04 -2.67e-01 6.16e-03
Signaling by high-kinase activity BRAF mutants 31 1.01e-02 2.67e-01 4.74e-02
Signaling by ROBO receptors 199 8.42e-11 -2.67e-01 3.19e-09
Presynaptic phase of homologous DNA pairing and strand exchange 39 4.07e-03 -2.66e-01 2.31e-02
Mitochondrial translation termination 91 1.17e-05 -2.66e-01 1.93e-04
Defects in cobalamin (B12) metabolism 13 9.77e-02 -2.65e-01 2.50e-01
CD28 dependent PI3K/Akt signaling 22 3.23e-02 -2.64e-01 1.13e-01
Degradation of the extracellular matrix 78 5.98e-05 2.63e-01 8.07e-04
Mitochondrial translation initiation 91 1.48e-05 -2.63e-01 2.31e-04
Regulation of signaling by CBL 18 5.47e-02 2.62e-01 1.65e-01
Integrin signaling 22 3.38e-02 2.61e-01 1.17e-01
Metabolism of steroid hormones 20 4.53e-02 2.59e-01 1.44e-01
Regulation of HSF1-mediated heat shock response 79 7.09e-05 -2.59e-01 9.10e-04
DNA Damage Bypass 47 2.22e-03 -2.58e-01 1.41e-02
Carnitine metabolism 10 1.58e-01 2.58e-01 3.46e-01
Glycogen breakdown (glycogenolysis) 13 1.08e-01 2.57e-01 2.70e-01
Tight junction interactions 18 5.88e-02 -2.57e-01 1.73e-01
IRAK1 recruits IKK complex 10 1.59e-01 2.57e-01 3.46e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 1.59e-01 2.57e-01 3.46e-01
RHO GTPases activate PAKs 20 4.66e-02 2.57e-01 1.47e-01
Fanconi Anemia Pathway 36 7.64e-03 -2.57e-01 3.90e-02
SUMOylation of DNA damage response and repair proteins 77 9.89e-05 -2.57e-01 1.18e-03
Mitochondrial translation 97 1.26e-05 -2.57e-01 1.99e-04
RHO GTPases activate PKNs 48 2.14e-03 2.56e-01 1.37e-02
FCERI mediated MAPK activation 90 2.82e-05 -2.55e-01 4.09e-04
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.21e-02 -2.54e-01 8.51e-02
activated TAK1 mediates p38 MAPK activation 19 5.54e-02 2.54e-01 1.65e-01
Viral Messenger RNA Synthesis 44 3.57e-03 -2.54e-01 2.09e-02
Caspase activation via extrinsic apoptotic signalling pathway 25 2.81e-02 2.54e-01 1.02e-01
Telomere Maintenance 80 9.00e-05 -2.53e-01 1.09e-03
CDC6 association with the ORC:origin complex 11 1.46e-01 -2.53e-01 3.32e-01
Antigen processing-Cross presentation 97 1.74e-05 2.52e-01 2.66e-04
Nuclear Envelope Breakdown 53 1.69e-03 -2.49e-01 1.11e-02
mRNA decay by 5’ to 3’ exoribonuclease 15 9.46e-02 -2.49e-01 2.46e-01
ISG15 antiviral mechanism 72 2.79e-04 -2.48e-01 2.63e-03
Golgi Associated Vesicle Biogenesis 55 1.61e-03 2.46e-01 1.06e-02
Adenylate cyclase inhibitory pathway 11 1.59e-01 2.45e-01 3.46e-01
Plasma lipoprotein clearance 29 2.23e-02 2.45e-01 8.51e-02
NOTCH2 intracellular domain regulates transcription 11 1.61e-01 2.44e-01 3.49e-01
RNA Polymerase I Transcription Termination 27 2.88e-02 -2.43e-01 1.04e-01
Pyrimidine salvage 10 1.84e-01 2.43e-01 3.78e-01
ER to Golgi Anterograde Transport 129 2.04e-06 2.42e-01 4.16e-05
RAS processing 19 6.84e-02 -2.41e-01 1.90e-01
Costimulation by the CD28 family 74 3.57e-04 -2.40e-01 3.18e-03
Cellular response to heat stress 93 6.51e-05 -2.40e-01 8.53e-04
SUMOylation of ubiquitinylation proteins 39 9.70e-03 -2.39e-01 4.64e-02
Myogenesis 21 5.81e-02 2.39e-01 1.72e-01
Nephrin family interactions 17 8.83e-02 -2.39e-01 2.34e-01
PI-3K cascade:FGFR2 12 1.54e-01 -2.37e-01 3.43e-01
Transport of Mature Transcript to Cytoplasm 81 2.22e-04 -2.37e-01 2.24e-03
rRNA processing in the mitochondrion 27 3.33e-02 -2.37e-01 1.16e-01
COPII-mediated vesicle transport 65 9.90e-04 2.36e-01 7.58e-03
Signaling by RAF1 mutants 34 1.74e-02 2.36e-01 7.07e-02
Endogenous sterols 17 9.45e-02 2.34e-01 2.46e-01
Energy dependent regulation of mTOR by LKB1-AMPK 27 3.53e-02 2.34e-01 1.20e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 9.57e-02 -2.33e-01 2.47e-01
Mitochondrial protein import 64 1.29e-03 -2.33e-01 9.17e-03
Effects of PIP2 hydrolysis 24 4.98e-02 -2.31e-01 1.55e-01
Interleukin-15 signaling 14 1.34e-01 2.31e-01 3.17e-01
Glycosphingolipid metabolism 36 1.66e-02 2.31e-01 6.88e-02
Cytochrome c-mediated apoptotic response 13 1.50e-01 2.30e-01 3.36e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 6.76e-02 -2.30e-01 1.90e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 6.76e-02 -2.30e-01 1.90e-01
Acetylcholine Neurotransmitter Release Cycle 11 1.86e-01 -2.30e-01 3.80e-01
Antiviral mechanism by IFN-stimulated genes 80 3.74e-04 -2.30e-01 3.25e-03
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.68e-01 2.30e-01 3.59e-01
APC-Cdc20 mediated degradation of Nek2A 26 4.32e-02 -2.29e-01 1.39e-01
Metabolism of porphyrins 22 6.35e-02 2.29e-01 1.80e-01
Regulation of TP53 Expression and Degradation 36 1.81e-02 -2.28e-01 7.26e-02
Frs2-mediated activation 11 1.92e-01 2.27e-01 3.86e-01
RNA Polymerase III Transcription Termination 23 5.94e-02 -2.27e-01 1.73e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 1.06e-01 -2.27e-01 2.67e-01
Formation of the cornified envelope 21 7.29e-02 2.26e-01 2.00e-01
HDR through Single Strand Annealing (SSA) 37 1.74e-02 -2.26e-01 7.07e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 1.35e-02 2.26e-01 5.87e-02
Synthesis of PC 24 5.64e-02 2.25e-01 1.67e-01
Clathrin-mediated endocytosis 127 1.21e-05 2.25e-01 1.96e-04
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 1.65e-02 -2.25e-01 6.88e-02
HDMs demethylate histones 22 6.88e-02 2.24e-01 1.90e-01
Regulation of Complement cascade 95 1.82e-04 -2.22e-01 1.97e-03
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 1.66e-01 -2.22e-01 3.55e-01
Butyrophilin (BTN) family interactions 10 2.25e-01 -2.22e-01 4.27e-01
ADP signalling through P2Y purinoceptor 1 21 7.90e-02 2.21e-01 2.13e-01
GABA receptor activation 35 2.36e-02 2.21e-01 8.87e-02
Late endosomal microautophagy 30 3.65e-02 2.21e-01 1.23e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 4.74e-02 2.20e-01 1.48e-01
Cross-presentation of soluble exogenous antigens (endosomes) 47 9.26e-03 2.19e-01 4.53e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 1.19e-01 -2.19e-01 2.90e-01
Signaling by FGFR3 in disease 13 1.73e-01 -2.18e-01 3.65e-01
Signaling by FGFR3 point mutants in cancer 13 1.73e-01 -2.18e-01 3.65e-01
Processing of Capped Intron-Containing Pre-mRNA 238 6.69e-09 -2.18e-01 2.28e-07
Assembly of active LPL and LIPC lipase complexes 10 2.33e-01 2.18e-01 4.39e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 16 1.32e-01 -2.18e-01 3.15e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.21e-01 2.17e-01 2.95e-01
Semaphorin interactions 57 4.86e-03 2.16e-01 2.68e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 21 8.84e-02 2.15e-01 2.34e-01
Neurodegenerative Diseases 21 8.84e-02 2.15e-01 2.34e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.98e-01 2.14e-01 3.95e-01
Base Excision Repair 58 4.84e-03 -2.14e-01 2.68e-02
Complement cascade 99 2.37e-04 -2.14e-01 2.36e-03
Sealing of the nuclear envelope (NE) by ESCRT-III 25 6.47e-02 2.13e-01 1.83e-01
Glutathione conjugation 26 6.02e-02 2.13e-01 1.74e-01
Signaling by Activin 10 2.44e-01 -2.13e-01 4.51e-01
Resolution of Sister Chromatid Cohesion 104 1.80e-04 -2.13e-01 1.97e-03
FOXO-mediated transcription of cell cycle genes 15 1.55e-01 -2.12e-01 3.44e-01
Cargo recognition for clathrin-mediated endocytosis 90 5.06e-04 2.12e-01 4.26e-03
PPARA activates gene expression 104 1.94e-04 2.11e-01 2.04e-03
Regulation of TP53 Degradation 35 3.04e-02 -2.11e-01 1.07e-01
Spry regulation of FGF signaling 16 1.44e-01 2.11e-01 3.31e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 1.32e-01 -2.11e-01 3.15e-01
RAB GEFs exchange GTP for GDP on RABs 88 6.40e-04 2.11e-01 5.35e-03
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 1.73e-01 -2.10e-01 3.65e-01
RA biosynthesis pathway 13 1.90e-01 -2.10e-01 3.84e-01
Diseases of carbohydrate metabolism 29 5.18e-02 2.09e-01 1.58e-01
Deadenylation of mRNA 22 9.08e-02 -2.08e-01 2.38e-01
S Phase 160 5.65e-06 -2.08e-01 1.01e-04
mRNA Splicing - Major Pathway 179 1.67e-06 -2.08e-01 3.49e-05
Inflammasomes 20 1.08e-01 2.07e-01 2.70e-01
EPH-ephrin mediated repulsion of cells 40 2.32e-02 2.07e-01 8.77e-02
Activation of GABAB receptors 30 5.03e-02 2.06e-01 1.55e-01
GABA B receptor activation 30 5.03e-02 2.06e-01 1.55e-01
ER-Phagosome pathway 82 1.26e-03 2.06e-01 9.01e-03
Deposition of new CENPA-containing nucleosomes at the centromere 40 2.57e-02 -2.04e-01 9.48e-02
Nucleosome assembly 40 2.57e-02 -2.04e-01 9.48e-02
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 2.42e-01 -2.04e-01 4.51e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 4.31e-02 2.03e-01 1.39e-01
Erythrocytes take up carbon dioxide and release oxygen 12 2.24e-01 2.03e-01 4.26e-01
O2/CO2 exchange in erythrocytes 12 2.24e-01 2.03e-01 4.26e-01
Cellular response to hypoxia 71 3.15e-03 2.03e-01 1.87e-02
HDR through Homologous Recombination (HRR) 66 4.48e-03 -2.02e-01 2.50e-02
Mitophagy 28 6.47e-02 -2.02e-01 1.83e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 8.84e-04 -2.02e-01 6.96e-03
Amplification of signal from the kinetochores 91 8.84e-04 -2.02e-01 6.96e-03
Processing and activation of SUMO 10 2.72e-01 -2.01e-01 4.82e-01
Regulation of lipid metabolism by PPARalpha 106 3.61e-04 2.00e-01 3.18e-03
Mitotic Prometaphase 184 2.79e-06 -2.00e-01 5.44e-05
TBC/RABGAPs 45 2.01e-02 2.00e-01 7.81e-02
Response of Mtb to phagocytosis 22 1.04e-01 2.00e-01 2.64e-01
mRNA Splicing 187 2.51e-06 -2.00e-01 4.96e-05
Polo-like kinase mediated events 16 1.70e-01 -1.98e-01 3.61e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 4.09e-06 -1.98e-01 7.55e-05
EML4 and NUDC in mitotic spindle formation 95 8.64e-04 -1.98e-01 6.88e-03
Innate Immune System 966 2.58e-25 1.97e-01 1.47e-23
G beta:gamma signalling through PI3Kgamma 22 1.10e-01 1.97e-01 2.73e-01
RNA Polymerase III Transcription Initiation 36 4.14e-02 -1.96e-01 1.36e-01
Metabolism of amino acids and derivatives 324 1.23e-09 -1.96e-01 4.29e-08
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 1.17e-03 1.96e-01 8.47e-03
Toll Like Receptor 2 (TLR2) Cascade 92 1.17e-03 1.96e-01 8.47e-03
Toll Like Receptor TLR1:TLR2 Cascade 92 1.17e-03 1.96e-01 8.47e-03
Toll Like Receptor TLR6:TLR2 Cascade 92 1.17e-03 1.96e-01 8.47e-03
GP1b-IX-V activation signalling 10 2.85e-01 -1.95e-01 4.95e-01
NCAM1 interactions 23 1.06e-01 -1.95e-01 2.67e-01
DCC mediated attractive signaling 13 2.24e-01 -1.95e-01 4.26e-01
SUMOylation of DNA methylation proteins 16 1.78e-01 -1.95e-01 3.72e-01
PIWI-interacting RNA (piRNA) biogenesis 23 1.07e-01 -1.94e-01 2.69e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 3.84e-02 1.94e-01 1.27e-01
Signaling by RAS mutants 38 3.84e-02 1.94e-01 1.27e-01
Signaling by moderate kinase activity BRAF mutants 38 3.84e-02 1.94e-01 1.27e-01
Signaling downstream of RAS mutants 38 3.84e-02 1.94e-01 1.27e-01
Assembly and cell surface presentation of NMDA receptors 18 1.57e-01 -1.93e-01 3.46e-01
RNA Polymerase I Promoter Opening 19 1.46e-01 1.92e-01 3.32e-01
Diseases associated with glycosylation precursor biosynthesis 18 1.58e-01 1.92e-01 3.46e-01
G1/S Transition 130 1.54e-04 -1.92e-01 1.71e-03
Signalling to ERKs 32 6.08e-02 1.91e-01 1.74e-01
Regulation of TP53 Activity through Association with Co-factors 11 2.72e-01 -1.91e-01 4.82e-01
Mitochondrial calcium ion transport 22 1.21e-01 -1.91e-01 2.94e-01
Interleukin-1 signaling 97 1.15e-03 1.91e-01 8.47e-03
TNFR1-induced proapoptotic signaling 12 2.52e-01 -1.91e-01 4.58e-01
PI-3K cascade:FGFR4 10 2.97e-01 -1.91e-01 5.08e-01
FOXO-mediated transcription of cell death genes 16 1.87e-01 1.91e-01 3.80e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 8.16e-02 -1.90e-01 2.19e-01
Mitotic Spindle Checkpoint 108 6.58e-04 -1.90e-01 5.47e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 2.19e-01 1.90e-01 4.21e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 8.75e-03 -1.89e-01 4.34e-02
NOTCH4 Intracellular Domain Regulates Transcription 17 1.77e-01 1.89e-01 3.71e-01
Smooth Muscle Contraction 31 6.84e-02 1.89e-01 1.90e-01
Dual incision in TC-NER 65 8.43e-03 -1.89e-01 4.22e-02
HSF1 activation 26 9.59e-02 -1.89e-01 2.47e-01
Tryptophan catabolism 12 2.58e-01 1.88e-01 4.66e-01
Membrane binding and targetting of GAG proteins 13 2.40e-01 1.88e-01 4.47e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 2.40e-01 1.88e-01 4.47e-01
Acyl chain remodelling of PC 19 1.56e-01 1.88e-01 3.45e-01
Olfactory Signaling Pathway 58 1.33e-02 1.88e-01 5.80e-02
Toll Like Receptor 4 (TLR4) Cascade 121 3.58e-04 1.88e-01 3.18e-03
Formation of apoptosome 11 2.81e-01 1.88e-01 4.92e-01
Regulation of the apoptosome activity 11 2.81e-01 1.88e-01 4.92e-01
Signaling by NOTCH4 78 4.14e-03 1.88e-01 2.34e-02
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 7.05e-02 -1.88e-01 1.95e-01
Assembly Of The HIV Virion 15 2.09e-01 1.87e-01 4.09e-01
RORA activates gene expression 18 1.69e-01 1.87e-01 3.60e-01
Regulation of TP53 Activity 151 7.29e-05 -1.87e-01 9.11e-04
TRAF3-dependent IRF activation pathway 13 2.44e-01 1.87e-01 4.51e-01
TRAF6 mediated IRF7 activation 15 2.13e-01 1.86e-01 4.16e-01
Interconversion of nucleotide di- and triphosphates 27 9.57e-02 -1.85e-01 2.47e-01
TP53 Regulates Transcription of Cell Cycle Genes 48 2.64e-02 -1.85e-01 9.67e-02
Pre-NOTCH Expression and Processing 65 9.90e-03 1.85e-01 4.68e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 3.11e-01 1.85e-01 5.22e-01
HCMV Early Events 74 5.95e-03 -1.85e-01 3.17e-02
Retinoid metabolism and transport 24 1.17e-01 1.85e-01 2.87e-01
Transport to the Golgi and subsequent modification 155 7.38e-05 1.84e-01 9.15e-04
Phase 4 - resting membrane potential 10 3.13e-01 1.84e-01 5.22e-01
MET promotes cell motility 26 1.04e-01 1.84e-01 2.64e-01
mRNA Splicing - Minor Pathway 52 2.16e-02 -1.84e-01 8.34e-02
RNA Polymerase II Transcription Termination 65 1.03e-02 -1.84e-01 4.83e-02
Activation of G protein gated Potassium channels 19 1.66e-01 1.84e-01 3.55e-01
G protein gated Potassium channels 19 1.66e-01 1.84e-01 3.55e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 1.66e-01 1.84e-01 3.55e-01
Processing of Capped Intronless Pre-mRNA 28 9.25e-02 -1.84e-01 2.41e-01
Rab regulation of trafficking 121 4.86e-04 1.84e-01 4.14e-03
Gene Silencing by RNA 87 3.09e-03 -1.84e-01 1.84e-02
L1CAM interactions 85 3.48e-03 1.83e-01 2.04e-02
Mitotic Telophase/Cytokinesis 13 2.53e-01 -1.83e-01 4.59e-01
Trafficking and processing of endosomal TLR 13 2.55e-01 1.82e-01 4.61e-01
Signal amplification 28 9.51e-02 1.82e-01 2.46e-01
Intra-Golgi traffic 43 3.87e-02 1.82e-01 1.28e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.23e-01 -1.82e-01 2.97e-01
Cell recruitment (pro-inflammatory response) 22 1.41e-01 1.81e-01 3.29e-01
Purinergic signaling in leishmaniasis infection 22 1.41e-01 1.81e-01 3.29e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.21e-02 1.81e-01 5.43e-02
SUMOylation 165 5.95e-05 -1.81e-01 8.07e-04
MTOR signalling 39 5.03e-02 1.81e-01 1.55e-01
FCERI mediated NF-kB activation 137 2.59e-04 -1.81e-01 2.50e-03
Potassium Channels 63 1.31e-02 1.81e-01 5.73e-02
Processing of SMDT1 15 2.26e-01 -1.81e-01 4.28e-01
Amino acids regulate mTORC1 50 2.74e-02 1.80e-01 9.97e-02
EPHA-mediated growth cone collapse 13 2.60e-01 1.80e-01 4.68e-01
Adherens junctions interactions 18 1.86e-01 1.80e-01 3.80e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 1.06e-01 -1.80e-01 2.67e-01
Toll-like Receptor Cascades 143 2.05e-04 1.80e-01 2.11e-03
Cytosolic sulfonation of small molecules 18 1.87e-01 1.80e-01 3.80e-01
Presynaptic function of Kainate receptors 18 1.87e-01 1.80e-01 3.80e-01
Formation of ATP by chemiosmotic coupling 18 1.88e-01 1.79e-01 3.83e-01
IRF3-mediated induction of type I IFN 12 2.83e-01 -1.79e-01 4.95e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 6.34e-03 -1.79e-01 3.35e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 2.16e-01 1.79e-01 4.19e-01
Apoptotic factor-mediated response 18 1.89e-01 1.79e-01 3.84e-01
PERK regulates gene expression 30 9.04e-02 -1.79e-01 2.38e-01
Common Pathway of Fibrin Clot Formation 14 2.48e-01 1.78e-01 4.55e-01
Hedgehog ligand biogenesis 58 1.89e-02 1.78e-01 7.52e-02
ABC transporters in lipid homeostasis 14 2.49e-01 -1.78e-01 4.55e-01
Signaling by MET 61 1.64e-02 1.78e-01 6.87e-02
Nucleotide salvage 21 1.59e-01 1.77e-01 3.47e-01
Membrane Trafficking 558 8.92e-13 1.77e-01 3.68e-11
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.52e-01 1.77e-01 3.39e-01
Gene expression (Transcription) 1323 4.44e-27 -1.76e-01 3.02e-25
Positive epigenetic regulation of rRNA expression 59 1.95e-02 -1.76e-01 7.63e-02
RUNX3 regulates NOTCH signaling 14 2.55e-01 1.76e-01 4.61e-01
Synthesis of DNA 118 9.81e-04 -1.76e-01 7.56e-03
Interleukin-6 signaling 10 3.36e-01 1.76e-01 5.49e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 1.16e-01 1.75e-01 2.85e-01
Caspase activation via Death Receptors in the presence of ligand 16 2.27e-01 1.74e-01 4.29e-01
Apoptosis induced DNA fragmentation 10 3.42e-01 1.74e-01 5.54e-01
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 53 2.91e-02 1.73e-01 1.04e-01
RNA Polymerase III Abortive And Retractive Initiation 41 5.53e-02 -1.73e-01 1.65e-01
RNA Polymerase III Transcription 41 5.53e-02 -1.73e-01 1.65e-01
IRAK2 mediated activation of TAK1 complex 10 3.46e-01 -1.72e-01 5.57e-01
ZBP1(DAI) mediated induction of type I IFNs 20 1.82e-01 1.72e-01 3.78e-01
SHC-mediated cascade:FGFR2 12 3.03e-01 -1.72e-01 5.16e-01
Interleukin-1 family signaling 124 9.64e-04 1.72e-01 7.46e-03
Ras activation upon Ca2+ influx through NMDA receptor 15 2.50e-01 -1.72e-01 4.55e-01
SUMO E3 ligases SUMOylate target proteins 159 1.91e-04 -1.71e-01 2.02e-03
Signaling by SCF-KIT 40 6.15e-02 1.71e-01 1.76e-01
Synthesis, secretion, and deacylation of Ghrelin 12 3.06e-01 -1.71e-01 5.19e-01
Transport of bile salts and organic acids, metal ions and amine compounds 55 2.91e-02 1.70e-01 1.04e-01
Regulation of PTEN stability and activity 66 1.72e-02 1.70e-01 7.07e-02
Golgi-to-ER retrograde transport 111 2.10e-03 1.69e-01 1.35e-02
Infection with Mycobacterium tuberculosis 26 1.36e-01 1.69e-01 3.21e-01
Regulation of ornithine decarboxylase (ODC) 49 4.16e-02 1.68e-01 1.36e-01
Triglyceride catabolism 16 2.45e-01 1.68e-01 4.52e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.47e-01 1.67e-01 3.32e-01
Cyclin A/B1/B2 associated events during G2/M transition 25 1.48e-01 -1.67e-01 3.32e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 1.48e-01 -1.67e-01 3.32e-01
Interleukin-27 signaling 11 3.38e-01 1.67e-01 5.50e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 3.61e-01 -1.67e-01 5.73e-01
Defective EXT2 causes exostoses 2 10 3.61e-01 -1.67e-01 5.73e-01
N-Glycan antennae elongation 13 2.99e-01 -1.67e-01 5.10e-01
Iron uptake and transport 52 3.78e-02 1.67e-01 1.26e-01
Carboxyterminal post-translational modifications of tubulin 26 1.44e-01 1.66e-01 3.31e-01
Eicosanoid ligand-binding receptors 13 3.02e-01 -1.65e-01 5.15e-01
Signaling by FGFR4 in disease 11 3.42e-01 -1.65e-01 5.54e-01
Generic Transcription Pathway 1077 5.34e-20 -1.65e-01 2.60e-18
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.02e-01 -1.65e-01 4.00e-01
Pre-NOTCH Transcription and Translation 49 4.66e-02 1.64e-01 1.47e-01
DNA Replication 125 1.51e-03 -1.64e-01 1.02e-02
RAF activation 32 1.08e-01 1.64e-01 2.70e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 9.36e-03 -1.64e-01 4.56e-02
Interleukin-37 signaling 19 2.17e-01 1.63e-01 4.20e-01
FRS-mediated FGFR2 signaling 14 2.90e-01 -1.63e-01 5.01e-01
Glycogen storage diseases 13 3.08e-01 1.63e-01 5.21e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.76e-01 1.63e-01 3.69e-01
RAB geranylgeranylation 60 2.91e-02 1.63e-01 1.04e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 7.99e-03 1.63e-01 4.05e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 3.29e-01 1.63e-01 5.42e-01
Class I peroxisomal membrane protein import 20 2.09e-01 -1.62e-01 4.09e-01
PCP/CE pathway 86 9.42e-03 1.62e-01 4.57e-02
Signaling by cytosolic FGFR1 fusion mutants 17 2.48e-01 1.62e-01 4.55e-01
Regulation of TP53 Activity through Phosphorylation 88 8.97e-03 -1.61e-01 4.43e-02
Defective CFTR causes cystic fibrosis 59 3.24e-02 1.61e-01 1.13e-01
ERK/MAPK targets 22 1.92e-01 1.61e-01 3.86e-01
Cilium Assembly 180 1.99e-04 -1.61e-01 2.06e-03
Unblocking of NMDA receptors, glutamate binding and activation 12 3.35e-01 -1.61e-01 5.49e-01
Collagen formation 66 2.41e-02 1.61e-01 9.02e-02
Syndecan interactions 19 2.27e-01 -1.60e-01 4.28e-01
FGFR2 mutant receptor activation 22 1.93e-01 -1.60e-01 3.88e-01
GRB2 events in ERBB2 signaling 11 3.58e-01 -1.60e-01 5.70e-01
Processing of DNA double-strand break ends 71 1.98e-02 -1.60e-01 7.73e-02
Downregulation of TGF-beta receptor signaling 26 1.58e-01 -1.60e-01 3.46e-01
G beta:gamma signalling through CDC42 17 2.54e-01 1.60e-01 4.61e-01
Integration of energy metabolism 86 1.07e-02 1.59e-01 4.96e-02
Defective B3GAT3 causes JDSSDHD 11 3.62e-01 -1.59e-01 5.73e-01
Lysosphingolipid and LPA receptors 11 3.62e-01 -1.59e-01 5.73e-01
MET activates RAS signaling 10 3.85e-01 1.59e-01 5.92e-01
Hh mutants abrogate ligand secretion 54 4.49e-02 1.58e-01 1.43e-01
Suppression of phagosomal maturation 12 3.44e-01 1.58e-01 5.56e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 5.90e-02 1.58e-01 1.73e-01
RNA Polymerase II Transcription 1196 4.47e-20 -1.57e-01 2.26e-18
VEGFA-VEGFR2 Pathway 92 9.27e-03 1.57e-01 4.53e-02
Recruitment of NuMA to mitotic centrosomes 79 1.59e-02 -1.57e-01 6.73e-02
FGFR1 mutant receptor activation 23 1.93e-01 1.57e-01 3.88e-01
mTORC1-mediated signalling 24 1.84e-01 1.57e-01 3.78e-01
Regulation of PLK1 Activity at G2/M Transition 86 1.21e-02 -1.57e-01 5.41e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 6.08e-02 1.56e-01 1.74e-01
Prolactin receptor signaling 11 3.69e-01 -1.56e-01 5.81e-01
Signaling by NODAL 13 3.30e-01 -1.56e-01 5.42e-01
RIP-mediated NFkB activation via ZBP1 17 2.67e-01 1.56e-01 4.76e-01
Sphingolipid metabolism 78 1.76e-02 1.56e-01 7.10e-02
Signaling by BRAF and RAF fusions 57 4.25e-02 1.55e-01 1.39e-01
The phototransduction cascade 25 1.79e-01 -1.55e-01 3.73e-01
RUNX2 regulates bone development 23 1.98e-01 1.55e-01 3.95e-01
Formation of Incision Complex in GG-NER 43 7.88e-02 -1.55e-01 2.13e-01
Assembly of collagen fibrils and other multimeric structures 42 8.24e-02 1.55e-01 2.20e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 3.74e-01 -1.55e-01 5.87e-01
MyD88 dependent cascade initiated on endosome 88 1.25e-02 1.54e-01 5.53e-02
DNA Repair 289 6.78e-06 -1.54e-01 1.16e-04
Platelet activation, signaling and aggregation 221 8.16e-05 1.54e-01 1.00e-03
Lysine catabolism 11 3.78e-01 1.54e-01 5.89e-01
p130Cas linkage to MAPK signaling for integrins 11 3.78e-01 1.54e-01 5.89e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.20e-01 1.53e-01 5.32e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 3.22e-01 1.53e-01 5.33e-01
Nucleotide Excision Repair 110 5.66e-03 -1.53e-01 3.07e-02
G2/M DNA damage checkpoint 68 3.00e-02 -1.52e-01 1.06e-01
Cell Cycle 623 8.80e-11 -1.52e-01 3.24e-09
Degradation of DVL 54 5.48e-02 1.51e-01 1.65e-01
Vif-mediated degradation of APOBEC3G 52 6.03e-02 1.51e-01 1.74e-01
Signaling by BMP 21 2.34e-01 -1.50e-01 4.39e-01
Inwardly rectifying K+ channels 23 2.15e-01 1.49e-01 4.18e-01
Downstream signaling of activated FGFR2 19 2.60e-01 -1.49e-01 4.67e-01
HATs acetylate histones 93 1.29e-02 -1.49e-01 5.67e-02
XBP1(S) activates chaperone genes 47 7.76e-02 1.49e-01 2.10e-01
Mitotic G1 phase and G1/S transition 148 1.80e-03 -1.49e-01 1.17e-02
Signaling by FGFR2 in disease 32 1.46e-01 -1.48e-01 3.32e-01
Oncogenic MAPK signaling 73 2.86e-02 1.48e-01 1.03e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 3.39e-01 -1.48e-01 5.50e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 87 1.73e-02 1.48e-01 7.07e-02
Centrosome maturation 80 2.29e-02 -1.47e-01 8.71e-02
Recruitment of mitotic centrosome proteins and complexes 80 2.29e-02 -1.47e-01 8.71e-02
Signaling by NTRKs 116 6.47e-03 1.46e-01 3.39e-02
DNA Double-Strand Break Repair 135 3.38e-03 -1.46e-01 1.99e-02
Signaling by the B Cell Receptor (BCR) 162 1.38e-03 -1.46e-01 9.43e-03
Anti-inflammatory response favouring Leishmania parasite infection 169 1.13e-03 -1.45e-01 8.38e-03
Leishmania parasite growth and survival 169 1.13e-03 -1.45e-01 8.38e-03
RNA Polymerase I Promoter Clearance 63 4.65e-02 -1.45e-01 1.47e-01
RNA Polymerase I Transcription 63 4.65e-02 -1.45e-01 1.47e-01
Transcriptional regulation of white adipocyte differentiation 77 2.79e-02 1.45e-01 1.02e-01
mRNA 3’-end processing 56 6.16e-02 -1.44e-01 1.76e-01
Beta-catenin phosphorylation cascade 17 3.03e-01 1.44e-01 5.16e-01
Bile acid and bile salt metabolism 29 1.80e-01 1.44e-01 3.73e-01
Citric acid cycle (TCA cycle) 22 2.43e-01 1.44e-01 4.51e-01
Epigenetic regulation of gene expression 100 1.29e-02 -1.44e-01 5.67e-02
Defective B4GALT7 causes EDS, progeroid type 11 4.09e-01 -1.44e-01 6.18e-01
Negative regulation of NOTCH4 signaling 54 6.79e-02 1.44e-01 1.90e-01
Cell Cycle, Mitotic 501 4.02e-08 -1.43e-01 1.19e-06
G beta:gamma signalling through BTK 15 3.37e-01 1.43e-01 5.49e-01
Sialic acid metabolism 28 1.91e-01 1.43e-01 3.85e-01
Response to elevated platelet cytosolic Ca2+ 110 9.74e-03 1.43e-01 4.64e-02
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 6.78e-02 1.42e-01 1.90e-01
Phosphorylation of the APC/C 20 2.70e-01 -1.42e-01 4.81e-01
G beta:gamma signalling through PLC beta 17 3.11e-01 1.42e-01 5.22e-01
Homology Directed Repair 110 1.01e-02 -1.42e-01 4.74e-02
Cell Cycle Checkpoints 259 8.41e-05 -1.42e-01 1.02e-03
NR1H2 and NR1H3-mediated signaling 39 1.26e-01 1.42e-01 3.02e-01
Signaling by Insulin receptor 59 6.04e-02 1.41e-01 1.74e-01
Negative regulation of FGFR1 signaling 24 2.33e-01 1.41e-01 4.39e-01
Metabolism of fat-soluble vitamins 28 1.99e-01 1.40e-01 3.95e-01
IKK complex recruitment mediated by RIP1 23 2.44e-01 1.40e-01 4.51e-01
Post-chaperonin tubulin folding pathway 19 2.91e-01 1.40e-01 5.02e-01
Acyl chain remodelling of PI 10 4.44e-01 1.40e-01 6.45e-01
Ion channel transport 133 5.68e-03 1.39e-01 3.07e-02
Signaling by NOTCH1 66 5.11e-02 1.39e-01 1.57e-01
Regulation of Apoptosis 51 8.63e-02 1.39e-01 2.29e-01
Degradation of GLI1 by the proteasome 57 7.11e-02 1.38e-01 1.96e-01
Interleukin-10 signaling 34 1.63e-01 1.38e-01 3.52e-01
Signaling by NOTCH 182 1.32e-03 1.38e-01 9.29e-03
Inactivation, recovery and regulation of the phototransduction cascade 24 2.43e-01 -1.38e-01 4.51e-01
PKA activation in glucagon signalling 14 3.72e-01 1.38e-01 5.85e-01
Rho GTPase cycle 126 7.63e-03 1.38e-01 3.90e-02
Platelet Aggregation (Plug Formation) 28 2.08e-01 1.38e-01 4.08e-01
Asparagine N-linked glycosylation 269 1.06e-04 1.37e-01 1.26e-03
Pregnenolone biosynthesis 10 4.53e-01 1.37e-01 6.56e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 4.32e-01 -1.37e-01 6.33e-01
Platelet degranulation 106 1.50e-02 1.37e-01 6.35e-02
RET signaling 32 1.83e-01 1.36e-01 3.78e-01
ABC transporter disorders 70 4.99e-02 1.36e-01 1.55e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 3.67e-01 1.35e-01 5.78e-01
Kinesins 39 1.47e-01 -1.34e-01 3.32e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 9.71e-02 1.34e-01 2.49e-01
Oncogene Induced Senescence 33 1.83e-01 1.34e-01 3.78e-01
AURKA Activation by TPX2 71 5.11e-02 -1.34e-01 1.57e-01
Interleukin-2 family signaling 38 1.54e-01 1.34e-01 3.43e-01
Regulation of TP53 Activity through Methylation 19 3.14e-01 -1.33e-01 5.23e-01
IRE1alpha activates chaperones 49 1.07e-01 1.33e-01 2.68e-01
Striated Muscle Contraction 23 2.70e-01 1.33e-01 4.81e-01
FGFR2 alternative splicing 25 2.50e-01 -1.33e-01 4.55e-01
Anchoring of the basal body to the plasma membrane 96 2.46e-02 -1.33e-01 9.18e-02
NCAM signaling for neurite out-growth 43 1.32e-01 -1.33e-01 3.15e-01
Cell surface interactions at the vascular wall 174 2.60e-03 -1.32e-01 1.61e-02
Signaling by VEGF 100 2.22e-02 1.32e-01 8.51e-02
Loss of Nlp from mitotic centrosomes 68 5.94e-02 -1.32e-01 1.73e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 5.94e-02 -1.32e-01 1.73e-01
TRAF6 mediated NF-kB activation 23 2.73e-01 1.32e-01 4.82e-01
Interleukin-35 Signalling 12 4.29e-01 -1.32e-01 6.31e-01
Signaling by NTRK1 (TRKA) 101 2.23e-02 1.32e-01 8.51e-02
Signaling by Hippo 18 3.36e-01 1.31e-01 5.49e-01
Transcriptional regulation by small RNAs 63 7.24e-02 -1.31e-01 1.99e-01
Protein methylation 15 3.81e-01 -1.31e-01 5.90e-01
GAB1 signalosome 15 3.81e-01 1.31e-01 5.90e-01
Toll Like Receptor 9 (TLR9) Cascade 92 3.09e-02 1.30e-01 1.08e-01
WNT ligand biogenesis and trafficking 21 3.07e-01 1.29e-01 5.20e-01
MyD88-independent TLR4 cascade 96 2.93e-02 1.29e-01 1.04e-01
TRIF(TICAM1)-mediated TLR4 signaling 96 2.93e-02 1.29e-01 1.04e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 1.10e-01 1.28e-01 2.73e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 4.42e-01 1.28e-01 6.45e-01
Non-integrin membrane-ECM interactions 37 1.78e-01 -1.28e-01 3.72e-01
Deactivation of the beta-catenin transactivating complex 36 1.84e-01 -1.28e-01 3.78e-01
Synthesis of PE 12 4.43e-01 -1.28e-01 6.45e-01
Platelet homeostasis 68 6.86e-02 1.28e-01 1.90e-01
B-WICH complex positively regulates rRNA expression 44 1.43e-01 -1.28e-01 3.31e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 1.23e-01 1.26e-01 2.96e-01
p53-Independent DNA Damage Response 50 1.23e-01 1.26e-01 2.96e-01
p53-Independent G1/S DNA damage checkpoint 50 1.23e-01 1.26e-01 2.96e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 2.66e-01 -1.26e-01 4.75e-01
Signaling by FGFR1 38 1.79e-01 1.26e-01 3.73e-01
Glutamate Neurotransmitter Release Cycle 20 3.30e-01 -1.26e-01 5.42e-01
Triglyceride metabolism 25 2.77e-01 1.26e-01 4.88e-01
Stimuli-sensing channels 73 6.41e-02 1.25e-01 1.82e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 179 3.95e-03 1.25e-01 2.25e-02
Formation of TC-NER Pre-Incision Complex 53 1.17e-01 -1.25e-01 2.86e-01
Activation of gene expression by SREBF (SREBP) 42 1.62e-01 1.25e-01 3.51e-01
Glyoxylate metabolism and glycine degradation 24 2.92e-01 -1.24e-01 5.02e-01
Vitamin B5 (pantothenate) metabolism 17 3.77e-01 1.24e-01 5.89e-01
DNA Replication Pre-Initiation 82 5.27e-02 -1.24e-01 1.60e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.20e-01 1.23e-01 2.93e-01
Signaling by ERBB2 TMD/JMD mutants 17 3.79e-01 -1.23e-01 5.89e-01
Rap1 signalling 13 4.41e-01 1.23e-01 6.45e-01
tRNA processing in the mitochondrion 30 2.43e-01 -1.23e-01 4.51e-01
MyD88 cascade initiated on plasma membrane 82 5.43e-02 1.23e-01 1.64e-01
Toll Like Receptor 10 (TLR10) Cascade 82 5.43e-02 1.23e-01 1.64e-01
Toll Like Receptor 5 (TLR5) Cascade 82 5.43e-02 1.23e-01 1.64e-01
Basigin interactions 23 3.12e-01 -1.22e-01 5.22e-01
Repression of WNT target genes 14 4.30e-01 -1.22e-01 6.32e-01
Apoptotic execution phase 45 1.58e-01 1.22e-01 3.46e-01
Signaling by ERBB2 KD Mutants 20 3.48e-01 -1.21e-01 5.58e-01
RMTs methylate histone arginines 37 2.03e-01 -1.21e-01 4.01e-01
Synthesis of PIPs at the Golgi membrane 16 4.03e-01 1.21e-01 6.13e-01
Metabolism of steroids 119 2.30e-02 1.21e-01 8.72e-02
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 4.70e-01 1.20e-01 6.71e-01
MHC class II antigen presentation 101 3.72e-02 1.20e-01 1.25e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 3.47e-02 -1.20e-01 1.19e-01
Programmed Cell Death 178 5.82e-03 1.20e-01 3.14e-02
Glycogen metabolism 23 3.20e-01 1.20e-01 5.32e-01
Glycosaminoglycan metabolism 94 4.51e-02 1.20e-01 1.44e-01
Interleukin receptor SHC signaling 23 3.22e-01 1.19e-01 5.33e-01
Ubiquitin-dependent degradation of Cyclin D 50 1.46e-01 1.19e-01 3.32e-01
Aflatoxin activation and detoxification 14 4.41e-01 1.19e-01 6.45e-01
Signaling by NOTCH2 30 2.60e-01 1.19e-01 4.67e-01
Voltage gated Potassium channels 25 3.04e-01 1.19e-01 5.17e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 3.48e-01 -1.18e-01 5.58e-01
EGFR downregulation 27 2.88e-01 1.18e-01 4.99e-01
Signaling by Receptor Tyrosine Kinases 414 3.90e-05 1.18e-01 5.36e-04
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 4.80e-01 -1.18e-01 6.78e-01
Fc epsilon receptor (FCERI) signaling 190 5.23e-03 -1.17e-01 2.86e-02
Regulation of insulin secretion 60 1.16e-01 1.17e-01 2.85e-01
DNA Damage Recognition in GG-NER 38 2.10e-01 -1.17e-01 4.11e-01
Glucagon signaling in metabolic regulation 27 2.92e-01 1.17e-01 5.02e-01
Nicotinate metabolism 25 3.12e-01 1.17e-01 5.22e-01
Degradation of GLI2 by the proteasome 56 1.31e-01 1.17e-01 3.13e-01
Muscle contraction 135 1.93e-02 1.17e-01 7.59e-02
Condensation of Prometaphase Chromosomes 11 5.04e-01 -1.16e-01 6.95e-01
Nucleobase catabolism 28 2.87e-01 1.16e-01 4.98e-01
Formation of tubulin folding intermediates by CCT/TriC 22 3.46e-01 -1.16e-01 5.58e-01
The canonical retinoid cycle in rods (twilight vision) 10 5.26e-01 1.16e-01 7.16e-01
Metabolism of lipids 626 7.53e-07 1.16e-01 1.77e-05
Transport of vitamins, nucleosides, and related molecules 33 2.50e-01 1.16e-01 4.55e-01
Synthesis of IP3 and IP4 in the cytosol 22 3.48e-01 1.15e-01 5.58e-01
Hedgehog ‘on’ state 75 8.41e-02 1.15e-01 2.24e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.72e-01 1.15e-01 6.73e-01
PLC beta mediated events 43 1.92e-01 1.15e-01 3.86e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 1.47e-01 1.15e-01 3.32e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 1.47e-01 1.15e-01 3.32e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 1.47e-01 1.15e-01 3.32e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 1.47e-01 1.15e-01 3.32e-01
Signaling by NOTCH1 in Cancer 53 1.47e-01 1.15e-01 3.32e-01
Downstream TCR signaling 100 4.69e-02 -1.15e-01 1.47e-01
Surfactant metabolism 21 3.63e-01 1.15e-01 5.74e-01
Regulation of beta-cell development 19 3.88e-01 1.14e-01 5.94e-01
ADP signalling through P2Y purinoceptor 12 18 4.01e-01 1.14e-01 6.10e-01
HIV Life Cycle 144 1.85e-02 -1.14e-01 7.41e-02
p38MAPK events 13 4.79e-01 1.13e-01 6.77e-01
RHO GTPases Activate Formins 117 3.43e-02 -1.13e-01 1.18e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 82 7.62e-02 1.13e-01 2.08e-01
SHC1 events in EGFR signaling 12 4.98e-01 1.13e-01 6.91e-01
Metabolism of cofactors 19 3.94e-01 1.13e-01 6.03e-01
Metabolic disorders of biological oxidation enzymes 25 3.29e-01 1.13e-01 5.42e-01
SUMOylation of intracellular receptors 25 3.29e-01 1.13e-01 5.42e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 5.19e-01 -1.12e-01 7.11e-01
Signaling by NOTCH3 42 2.08e-01 1.12e-01 4.08e-01
Calnexin/calreticulin cycle 26 3.22e-01 1.12e-01 5.33e-01
NIK–>noncanonical NF-kB signaling 57 1.44e-01 1.12e-01 3.31e-01
FRS-mediated FGFR4 signaling 12 5.02e-01 -1.12e-01 6.93e-01
SHC-mediated cascade:FGFR4 10 5.40e-01 -1.12e-01 7.28e-01
Vesicle-mediated transport 648 1.24e-06 1.12e-01 2.72e-05
Downstream signaling of activated FGFR4 17 4.27e-01 -1.11e-01 6.29e-01
Miscellaneous transport and binding events 20 3.89e-01 -1.11e-01 5.95e-01
O-linked glycosylation of mucins 47 1.87e-01 1.11e-01 3.80e-01
G-protein mediated events 44 2.02e-01 1.11e-01 4.00e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 1.79e-01 1.11e-01 3.73e-01
Regulation of RUNX3 expression and activity 55 1.54e-01 1.11e-01 3.43e-01
Signaling by ERBB2 ECD mutants 15 4.58e-01 -1.11e-01 6.61e-01
Negative regulators of DDX58/IFIH1 signaling 34 2.65e-01 -1.11e-01 4.74e-01
Organelle biogenesis and maintenance 268 1.90e-03 -1.10e-01 1.23e-02
Dopamine Neurotransmitter Release Cycle 20 3.95e-01 -1.10e-01 6.03e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 3.76e-01 1.09e-01 5.88e-01
Glycerophospholipid biosynthesis 107 5.15e-02 1.09e-01 1.57e-01
Neuronal System 258 2.60e-03 1.09e-01 1.61e-02
O-glycosylation of TSR domain-containing proteins 26 3.37e-01 -1.09e-01 5.49e-01
Metabolism of Angiotensinogen to Angiotensins 11 5.36e-01 1.08e-01 7.25e-01
Apoptosis 166 1.67e-02 1.08e-01 6.91e-02
TP53 Regulates Transcription of DNA Repair Genes 61 1.46e-01 -1.08e-01 3.32e-01
Signaling by Interleukins 385 3.05e-04 1.07e-01 2.81e-03
TICAM1,TRAF6-dependent induction of TAK1 complex 11 5.38e-01 -1.07e-01 7.27e-01
Stabilization of p53 54 1.74e-01 1.07e-01 3.66e-01
G2/M Checkpoints 139 2.98e-02 -1.07e-01 1.05e-01
Regulation of KIT signaling 15 4.75e-01 1.06e-01 6.75e-01
Regulation of innate immune responses to cytosolic DNA 14 4.91e-01 -1.06e-01 6.86e-01
Endosomal/Vacuolar pathway 12 5.25e-01 -1.06e-01 7.16e-01
Meiosis 68 1.31e-01 -1.06e-01 3.14e-01
Opioid Signalling 75 1.14e-01 1.06e-01 2.81e-01
Activation of BH3-only proteins 29 3.25e-01 -1.06e-01 5.37e-01
Thromboxane signalling through TP receptor 20 4.14e-01 1.06e-01 6.19e-01
Platelet calcium homeostasis 21 4.03e-01 1.05e-01 6.13e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 3.44e-01 1.05e-01 5.55e-01
CTLA4 inhibitory signaling 21 4.04e-01 -1.05e-01 6.14e-01
Regulation of RAS by GAPs 66 1.42e-01 1.05e-01 3.30e-01
Norepinephrine Neurotransmitter Release Cycle 14 4.98e-01 -1.05e-01 6.91e-01
Dectin-1 mediated noncanonical NF-kB signaling 58 1.69e-01 1.04e-01 3.60e-01
Amyloid fiber formation 51 1.97e-01 1.04e-01 3.94e-01
Vpu mediated degradation of CD4 50 2.02e-01 1.04e-01 4.00e-01
ER Quality Control Compartment (ERQC) 21 4.08e-01 1.04e-01 6.18e-01
Host Interactions of HIV factors 129 4.15e-02 -1.04e-01 1.36e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 5.34e-01 -1.04e-01 7.24e-01
DNA methylation 20 4.23e-01 1.03e-01 6.26e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 3.11e-01 1.03e-01 5.22e-01
Degradation of cysteine and homocysteine 12 5.36e-01 1.03e-01 7.25e-01
Attenuation phase 23 3.95e-01 -1.02e-01 6.03e-01
Asymmetric localization of PCP proteins 60 1.71e-01 1.02e-01 3.62e-01
PI3K events in ERBB2 signaling 11 5.58e-01 -1.02e-01 7.44e-01
SUMOylation of transcription factors 16 4.80e-01 1.02e-01 6.78e-01
Apoptotic cleavage of cellular proteins 34 3.04e-01 1.02e-01 5.17e-01
Transcriptional regulation by RUNX2 101 7.72e-02 1.02e-01 2.10e-01
G-protein activation 23 4.00e-01 1.01e-01 6.10e-01
Interaction between L1 and Ankyrins 22 4.11e-01 -1.01e-01 6.19e-01
Phospholipid metabolism 186 1.74e-02 1.01e-01 7.07e-02
Collagen biosynthesis and modifying enzymes 48 2.26e-01 1.01e-01 4.28e-01
Signaling by ERBB2 in Cancer 21 4.23e-01 -1.01e-01 6.26e-01
Nucleotide-like (purinergic) receptors 12 5.47e-01 -1.01e-01 7.34e-01
Phase II - Conjugation of compounds 67 1.56e-01 1.00e-01 3.45e-01
Neurotransmitter receptors and postsynaptic signal transmission 123 5.51e-02 1.00e-01 1.65e-01
Degradation of AXIN 53 2.08e-01 1.00e-01 4.08e-01
Molecules associated with elastic fibres 22 4.19e-01 -9.96e-02 6.23e-01
NOD1/2 Signaling Pathway 32 3.30e-01 9.95e-02 5.42e-01
Cytochrome P450 - arranged by substrate type 34 3.16e-01 9.94e-02 5.25e-01
Metabolism of polyamines 57 1.94e-01 9.94e-02 3.89e-01
Synaptic adhesion-like molecules 14 5.20e-01 9.93e-02 7.12e-01
HSF1-dependent transactivation 29 3.56e-01 -9.91e-02 5.67e-01
Interleukin-17 signaling 68 1.58e-01 9.90e-02 3.46e-01
Separation of Sister Chromatids 167 2.74e-02 -9.90e-02 9.97e-02
GLI3 is processed to GLI3R by the proteasome 57 1.97e-01 9.88e-02 3.94e-01
SLC transporter disorders 77 1.34e-01 -9.88e-02 3.17e-01
SARS-CoV-1 Infection 47 2.42e-01 9.86e-02 4.51e-01
Other semaphorin interactions 16 4.95e-01 9.85e-02 6.90e-01
Transmission across Chemical Synapses 172 2.61e-02 9.83e-02 9.60e-02
Extracellular matrix organization 219 1.22e-02 9.82e-02 5.45e-02
Nuclear Events (kinase and transcription factor activation) 53 2.16e-01 9.82e-02 4.19e-01
Arachidonic acid metabolism 43 2.66e-01 9.81e-02 4.75e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 4.48e-01 9.79e-02 6.51e-01
COPI-dependent Golgi-to-ER retrograde traffic 78 1.35e-01 9.78e-02 3.19e-01
Activation of NF-kappaB in B cells 65 1.73e-01 9.77e-02 3.65e-01
Beta-catenin independent WNT signaling 136 5.01e-02 9.73e-02 1.55e-01
Cargo trafficking to the periciliary membrane 47 2.49e-01 -9.72e-02 4.55e-01
C-type lectin receptors (CLRs) 128 5.88e-02 9.67e-02 1.73e-01
GABA synthesis, release, reuptake and degradation 13 5.46e-01 -9.67e-02 7.34e-01
Nuclear Envelope (NE) Reassembly 69 1.66e-01 -9.65e-02 3.55e-01
CD28 dependent Vav1 pathway 12 5.65e-01 9.59e-02 7.51e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 5.50e-01 -9.58e-02 7.37e-01
Interleukin-20 family signaling 17 4.95e-01 9.55e-02 6.90e-01
Listeria monocytogenes entry into host cells 17 4.96e-01 9.53e-02 6.90e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 4.11e-01 9.51e-02 6.19e-01
Signaling by KIT in disease 20 4.62e-01 -9.50e-02 6.63e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 4.62e-01 -9.50e-02 6.63e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 5.54e-01 9.47e-02 7.42e-01
Autophagy 124 6.88e-02 9.46e-02 1.90e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 2.84e-01 -9.43e-02 4.95e-01
Downregulation of ERBB2 signaling 24 4.24e-01 -9.43e-02 6.27e-01
Metabolism of carbohydrates 244 1.13e-02 9.42e-02 5.15e-02
Ca-dependent events 29 3.82e-01 9.38e-02 5.90e-01
DAP12 interactions 39 3.13e-01 9.35e-02 5.22e-01
Negative epigenetic regulation of rRNA expression 62 2.05e-01 -9.32e-02 4.03e-01
Complex I biogenesis 55 2.36e-01 9.24e-02 4.42e-01
TP53 Regulates Metabolic Genes 84 1.44e-01 9.23e-02 3.31e-01
Transport of small molecules 557 1.99e-04 9.22e-02 2.06e-03
p75 NTR receptor-mediated signalling 89 1.34e-01 9.18e-02 3.17e-01
MAP kinase activation 63 2.08e-01 9.17e-02 4.08e-01
Keratan sulfate/keratin metabolism 27 4.12e-01 9.13e-02 6.19e-01
Transcriptional regulation of granulopoiesis 46 2.84e-01 9.13e-02 4.95e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 5.86e-01 9.09e-02 7.65e-01
Diseases of hemostasis 12 5.86e-01 9.09e-02 7.65e-01
Uptake and actions of bacterial toxins 27 4.14e-01 9.07e-02 6.19e-01
Chaperone Mediated Autophagy 20 4.83e-01 -9.06e-02 6.80e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 2.50e-01 -9.06e-02 4.55e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 3.47e-01 9.05e-02 5.58e-01
HDACs deacetylate histones 47 2.83e-01 9.05e-02 4.95e-01
Sphingolipid de novo biosynthesis 42 3.10e-01 9.04e-02 5.22e-01
Metal ion SLC transporters 21 4.74e-01 9.03e-02 6.73e-01
IRS-related events triggered by IGF1R 35 3.56e-01 -9.02e-02 5.67e-01
G2/M Transition 179 3.77e-02 -9.01e-02 1.26e-01
Toll Like Receptor 3 (TLR3) Cascade 92 1.37e-01 8.98e-02 3.21e-01
Synthesis of PIPs at the plasma membrane 52 2.64e-01 8.96e-02 4.73e-01
Phase 0 - rapid depolarisation 22 4.68e-01 -8.94e-02 6.69e-01
G alpha (12/13) signalling events 69 1.99e-01 8.93e-02 3.96e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 12 5.92e-01 8.93e-02 7.73e-01
Transcriptional regulation by RUNX3 90 1.44e-01 8.91e-02 3.31e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 5.39e-01 -8.86e-02 7.28e-01
Phase 2 - plateau phase 12 5.95e-01 8.86e-02 7.75e-01
IRS-mediated signalling 34 3.72e-01 -8.84e-02 5.85e-01
Collagen chain trimerization 27 4.29e-01 -8.80e-02 6.31e-01
Fatty acid metabolism 152 6.13e-02 8.79e-02 1.76e-01
RUNX2 regulates osteoblast differentiation 18 5.19e-01 8.78e-02 7.11e-01
TCR signaling 121 9.61e-02 -8.76e-02 2.47e-01
Termination of O-glycan biosynthesis 16 5.44e-01 8.75e-02 7.33e-01
Signaling by FGFR2 IIIa TM 18 5.22e-01 -8.71e-02 7.13e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 3.60e-01 -8.70e-02 5.72e-01
Mitotic G2-G2/M phases 181 4.44e-02 -8.66e-02 1.42e-01
CASP8 activity is inhibited 11 6.19e-01 -8.66e-02 7.91e-01
Dimerization of procaspase-8 11 6.19e-01 -8.66e-02 7.91e-01
Regulation by c-FLIP 11 6.19e-01 -8.66e-02 7.91e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 25 4.54e-01 -8.65e-02 6.56e-01
Signaling by FGFR1 in disease 30 4.12e-01 8.65e-02 6.19e-01
Mitotic Metaphase and Anaphase 224 2.57e-02 -8.65e-02 9.48e-02
Aquaporin-mediated transport 37 3.63e-01 8.64e-02 5.74e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 4.85e-01 -8.60e-02 6.81e-01
Methylation 12 6.06e-01 -8.59e-02 7.85e-01
Diseases of programmed cell death 28 4.32e-01 8.58e-02 6.33e-01
Interleukin-6 family signaling 18 5.28e-01 8.58e-02 7.18e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 4.87e-01 8.56e-02 6.82e-01
DNA Double Strand Break Response 47 3.12e-01 -8.52e-02 5.22e-01
M Phase 359 5.87e-03 -8.46e-02 3.15e-02
Transcriptional Regulation by TP53 351 6.51e-03 -8.45e-02 3.40e-02
Nonhomologous End-Joining (NHEJ) 42 3.44e-01 -8.44e-02 5.55e-01
Nuclear Receptor transcription pathway 36 3.81e-01 -8.43e-02 5.90e-01
Incretin synthesis, secretion, and inactivation 10 6.45e-01 -8.42e-02 8.09e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 6.45e-01 -8.42e-02 8.09e-01
PI3K Cascade 30 4.25e-01 -8.42e-02 6.27e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 4.11e-01 -8.40e-02 6.19e-01
DARPP-32 events 22 4.98e-01 8.34e-02 6.91e-01
RNA Polymerase I Promoter Escape 44 3.39e-01 -8.33e-02 5.50e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 3.87e-01 8.33e-02 5.94e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 2.22e-01 8.33e-02 4.23e-01
Metabolism of nucleotides 86 1.82e-01 -8.33e-02 3.78e-01
Tie2 Signaling 16 5.64e-01 8.32e-02 7.51e-01
Fertilization 12 6.18e-01 8.31e-02 7.91e-01
Mitotic Anaphase 223 3.35e-02 -8.26e-02 1.16e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 2.77e-01 8.25e-02 4.88e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 2.55e-01 8.22e-02 4.61e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 4.68e-01 -8.22e-02 6.69e-01
TNFR1-induced NFkappaB signaling pathway 25 4.77e-01 -8.22e-02 6.76e-01
G alpha (s) signalling events 141 9.21e-02 8.22e-02 2.41e-01
Signaling by Rho GTPases 367 7.03e-03 8.19e-02 3.63e-02
Post-translational modification: synthesis of GPI-anchored proteins 57 2.85e-01 8.19e-02 4.95e-01
Peroxisomal lipid metabolism 27 4.62e-01 8.18e-02 6.63e-01
Infectious disease 775 1.11e-04 -8.16e-02 1.30e-03
Downregulation of ERBB2:ERBB3 signaling 12 6.24e-01 -8.16e-02 7.92e-01
Late Phase of HIV Life Cycle 131 1.10e-01 -8.09e-02 2.73e-01
Diseases of signal transduction by growth factor receptors and second messengers 339 1.05e-02 8.09e-02 4.87e-02
Downstream signaling of activated FGFR3 16 5.75e-01 -8.09e-02 7.57e-01
Glucagon-type ligand receptors 20 5.32e-01 -8.07e-02 7.22e-01
Signaling by FGFR2 60 2.81e-01 -8.06e-02 4.92e-01
PI Metabolism 80 2.14e-01 8.04e-02 4.16e-01
Synthesis of PIPs at the late endosome membrane 11 6.45e-01 8.03e-02 8.09e-01
Josephin domain DUBs 10 6.60e-01 8.03e-02 8.21e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 5.56e-01 -8.02e-02 7.43e-01
Peroxisomal protein import 57 2.96e-01 8.01e-02 5.07e-01
Netrin-1 signaling 40 3.82e-01 -7.99e-02 5.90e-01
Activation of SMO 13 6.19e-01 7.97e-02 7.91e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 5.41e-01 7.89e-02 7.29e-01
Cellular responses to stress 499 2.61e-03 -7.87e-02 1.61e-02
Activation of BAD and translocation to mitochondria 15 5.98e-01 7.87e-02 7.77e-01
G alpha (z) signalling events 36 4.16e-01 7.84e-02 6.20e-01
SARS-CoV-2 Infection 63 2.82e-01 7.83e-02 4.94e-01
MAPK6/MAPK4 signaling 82 2.21e-01 7.82e-02 4.23e-01
Interferon Signaling 177 7.37e-02 -7.79e-02 2.02e-01
Mitotic Prophase 98 1.83e-01 -7.78e-02 3.78e-01
Inositol phosphate metabolism 42 3.84e-01 7.76e-02 5.91e-01
Reproduction 80 2.31e-01 -7.75e-02 4.35e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 4.21e-01 -7.74e-02 6.25e-01
Diseases of mitotic cell cycle 36 4.21e-01 -7.74e-02 6.25e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 3.64e-01 -7.74e-02 5.74e-01
VEGFR2 mediated vascular permeability 27 4.88e-01 7.72e-02 6.82e-01
PTEN Regulation 138 1.18e-01 7.71e-02 2.88e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 5.94e-01 7.71e-02 7.73e-01
UCH proteinases 86 2.17e-01 7.70e-02 4.19e-01
Cardiac conduction 86 2.21e-01 7.63e-02 4.23e-01
Immune System 1892 4.20e-08 7.62e-02 1.22e-06
CD209 (DC-SIGN) signaling 20 5.56e-01 7.60e-02 7.43e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 6.79e-01 -7.55e-02 8.33e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 6.04e-01 7.50e-02 7.83e-01
RHO GTPase Effectors 250 4.32e-02 7.43e-02 1.39e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 6.71e-01 7.40e-02 8.31e-01
Elevation of cytosolic Ca2+ levels 12 6.59e-01 7.35e-02 8.21e-01
Cellular responses to external stimuli 505 4.74e-03 -7.34e-02 2.64e-02
APC/C:Cdc20 mediated degradation of Securin 66 3.03e-01 7.33e-02 5.16e-01
Regulation of TNFR1 signaling 34 4.60e-01 -7.31e-02 6.63e-01
Sema3A PAK dependent Axon repulsion 16 6.13e-01 7.30e-02 7.89e-01
Cellular hexose transport 15 6.25e-01 -7.29e-02 7.92e-01
Serotonin Neurotransmitter Release Cycle 15 6.29e-01 -7.21e-02 7.96e-01
PKMTs methylate histone lysines 44 4.12e-01 -7.15e-02 6.19e-01
RUNX3 regulates p14-ARF 10 6.96e-01 7.14e-02 8.47e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 5.80e-01 7.14e-02 7.61e-01
Trafficking of AMPA receptors 20 5.80e-01 7.14e-02 7.61e-01
Branched-chain amino acid catabolism 21 5.72e-01 -7.13e-02 7.54e-01
Switching of origins to a post-replicative state 89 2.46e-01 -7.12e-02 4.52e-01
SCF-beta-TrCP mediated degradation of Emi1 53 3.77e-01 7.01e-02 5.89e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 4.73e-01 7.01e-02 6.73e-01
IGF1R signaling cascade 36 4.70e-01 -6.96e-02 6.71e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 4.96e-01 -6.95e-02 6.90e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 5.18e-01 6.93e-02 7.11e-01
Signaling by Non-Receptor Tyrosine Kinases 48 4.07e-01 6.93e-02 6.16e-01
Signaling by PTK6 48 4.07e-01 6.93e-02 6.16e-01
Degradation of beta-catenin by the destruction complex 83 2.77e-01 6.90e-02 4.88e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 4.88e-01 6.87e-02 6.82e-01
Protein localization 157 1.38e-01 -6.86e-02 3.24e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 5.70e-01 -6.85e-02 7.54e-01
SLC-mediated transmembrane transport 180 1.16e-01 6.79e-02 2.86e-01
CD28 co-stimulation 33 5.00e-01 -6.79e-02 6.92e-01
Activation of the AP-1 family of transcription factors 10 7.10e-01 6.78e-02 8.58e-01
FRS-mediated FGFR3 signaling 11 6.97e-01 -6.78e-02 8.48e-01
Macroautophagy 110 2.20e-01 6.77e-02 4.21e-01
Processing of Intronless Pre-mRNAs 19 6.09e-01 -6.77e-02 7.87e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 6.01e-01 -6.76e-02 7.80e-01
Retrograde transport at the Trans-Golgi-Network 49 4.14e-01 6.75e-02 6.19e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 5.16e-01 6.74e-02 7.09e-01
Interleukin-12 signaling 44 4.43e-01 6.69e-02 6.45e-01
CRMPs in Sema3A signaling 14 6.68e-01 6.63e-02 8.29e-01
SHC-mediated cascade:FGFR1 12 6.93e-01 6.59e-02 8.44e-01
MASTL Facilitates Mitotic Progression 10 7.19e-01 -6.57e-02 8.64e-01
Keratinization 32 5.21e-01 6.55e-02 7.12e-01
FCGR3A-mediated phagocytosis 121 2.19e-01 -6.48e-02 4.20e-01
Leishmania phagocytosis 121 2.19e-01 -6.48e-02 4.20e-01
Parasite infection 121 2.19e-01 -6.48e-02 4.20e-01
Interleukin-12 family signaling 53 4.15e-01 6.47e-02 6.20e-01
CLEC7A (Dectin-1) signaling 96 2.74e-01 6.46e-02 4.84e-01
GRB2 events in EGFR signaling 11 7.12e-01 6.44e-02 8.58e-01
Negative regulation of FGFR3 signaling 20 6.18e-01 6.43e-02 7.91e-01
Meiotic synapsis 45 4.58e-01 -6.39e-02 6.61e-01
Resolution of D-Loop Structures 33 5.27e-01 -6.37e-02 7.17e-01
p53-Dependent G1 DNA Damage Response 63 3.84e-01 6.35e-02 5.91e-01
p53-Dependent G1/S DNA damage checkpoint 63 3.84e-01 6.35e-02 5.91e-01
ABC-family proteins mediated transport 93 2.97e-01 6.26e-02 5.08e-01
Oxidative Stress Induced Senescence 79 3.36e-01 6.26e-02 5.49e-01
Acyl chain remodelling of PG 11 7.19e-01 6.26e-02 8.64e-01
NoRC negatively regulates rRNA expression 59 4.13e-01 -6.16e-02 6.19e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 2.38e-01 6.14e-02 4.45e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 5.67e-01 -6.14e-02 7.52e-01
NOTCH1 Intracellular Domain Regulates Transcription 44 4.81e-01 6.13e-02 6.79e-01
Respiratory electron transport 101 2.87e-01 6.13e-02 4.98e-01
Orc1 removal from chromatin 69 3.81e-01 -6.09e-02 5.90e-01
MECP2 regulates neuronal receptors and channels 13 7.04e-01 -6.08e-02 8.55e-01
Metalloprotease DUBs 21 6.31e-01 6.06e-02 7.98e-01
Platelet Adhesion to exposed collagen 13 7.09e-01 -5.98e-02 8.57e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 5.38e-01 -5.93e-02 7.27e-01
Blood group systems biosynthesis 17 6.72e-01 -5.92e-02 8.31e-01
Aggrephagy 22 6.32e-01 -5.89e-02 7.99e-01
Glucose metabolism 84 3.52e-01 5.87e-02 5.63e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 5.62e-01 -5.75e-02 7.48e-01
Signaling by EGFR 46 5.00e-01 5.75e-02 6.92e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 6.29e-01 -5.70e-02 7.96e-01
Signaling by PDGFRA extracellular domain mutants 12 7.33e-01 5.69e-02 8.76e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 7.33e-01 5.69e-02 8.76e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 6.85e-01 -5.68e-02 8.37e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 7.58e-01 -5.63e-02 8.86e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 18 6.81e-01 -5.60e-02 8.34e-01
Metabolism of folate and pterines 16 6.99e-01 5.59e-02 8.49e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 6.13e-01 5.53e-02 7.89e-01
Chromatin modifying enzymes 217 1.63e-01 -5.50e-02 3.51e-01
Chromatin organization 217 1.63e-01 -5.50e-02 3.51e-01
Fatty acyl-CoA biosynthesis 34 5.80e-01 5.48e-02 7.61e-01
Biological oxidations 135 2.72e-01 5.47e-02 4.82e-01
Signaling by WNT 253 1.35e-01 5.45e-02 3.19e-01
Synthesis of bile acids and bile salts 24 6.44e-01 5.45e-02 8.09e-01
Zinc transporters 14 7.24e-01 5.44e-02 8.69e-01
Cell death signalling via NRAGE, NRIF and NADE 70 4.32e-01 5.43e-02 6.33e-01
Xenobiotics 11 7.56e-01 -5.42e-02 8.84e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 7.09e-01 5.40e-02 8.57e-01
Cytosolic iron-sulfur cluster assembly 13 7.39e-01 -5.34e-02 8.79e-01
Signaling by Hedgehog 120 3.14e-01 5.33e-02 5.23e-01
PRC2 methylates histones and DNA 29 6.21e-01 -5.31e-02 7.92e-01
Signaling by TGFB family members 91 3.83e-01 -5.30e-02 5.91e-01
Regulation of PTEN mRNA translation 13 7.42e-01 5.28e-02 8.79e-01
mRNA Capping 29 6.22e-01 -5.28e-02 7.92e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 7.75e-01 5.23e-02 8.95e-01
MicroRNA (miRNA) biogenesis 24 6.58e-01 -5.22e-02 8.21e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 6.52e-01 5.21e-02 8.17e-01
Death Receptor Signalling 132 3.10e-01 5.11e-02 5.22e-01
Phase I - Functionalization of compounds 63 4.84e-01 5.09e-02 6.81e-01
The citric acid (TCA) cycle and respiratory electron transport 172 2.50e-01 5.09e-02 4.55e-01
Transcription of the HIV genome 67 4.73e-01 -5.08e-02 6.73e-01
Selective autophagy 58 5.07e-01 -5.04e-02 6.98e-01
CDT1 association with the CDC6:ORC:origin complex 57 5.11e-01 5.04e-02 7.03e-01
SCF(Skp2)-mediated degradation of p27/p21 60 5.01e-01 5.02e-02 6.93e-01
Regulation of RUNX2 expression and activity 66 4.84e-01 4.98e-02 6.81e-01
Protein folding 90 4.16e-01 4.97e-02 6.20e-01
Ion transport by P-type ATPases 42 5.78e-01 4.96e-02 7.60e-01
Signaling by TGF-beta Receptor Complex 72 4.67e-01 -4.95e-02 6.69e-01
SUMOylation of transcription cofactors 44 5.71e-01 -4.94e-02 7.54e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 4.27e-01 4.93e-02 6.29e-01
TGF-beta receptor signaling activates SMADs 32 6.36e-01 -4.84e-02 8.02e-01
Regulation of actin dynamics for phagocytic cup formation 123 3.55e-01 -4.83e-02 5.67e-01
CDK-mediated phosphorylation and removal of Cdc6 71 4.82e-01 4.83e-02 6.79e-01
Axon guidance 455 7.79e-02 -4.82e-02 2.11e-01
Signaling by Retinoic Acid 31 6.42e-01 -4.82e-02 8.09e-01
HIV Infection 224 2.14e-01 -4.82e-02 4.16e-01
Metabolism of proteins 1714 9.36e-04 -4.81e-02 7.29e-03
Misspliced GSK3beta mutants stabilize beta-catenin 15 7.47e-01 4.81e-02 8.79e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 7.47e-01 4.81e-02 8.79e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 7.47e-01 4.81e-02 8.79e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 7.47e-01 4.81e-02 8.79e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 7.47e-01 4.81e-02 8.79e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 7.47e-01 4.81e-02 8.79e-01
Meiotic recombination 38 6.09e-01 -4.79e-02 7.87e-01
SHC1 events in ERBB2 signaling 17 7.33e-01 4.78e-02 8.76e-01
Signaling by GPCR 536 5.98e-02 4.75e-02 1.74e-01
Chaperonin-mediated protein folding 84 4.54e-01 4.73e-02 6.56e-01
Glycogen synthesis 13 7.70e-01 4.69e-02 8.93e-01
Neurexins and neuroligins 37 6.22e-01 -4.68e-02 7.92e-01
Estrogen-dependent gene expression 99 4.21e-01 -4.68e-02 6.25e-01
G1/S DNA Damage Checkpoints 65 5.16e-01 4.66e-02 7.09e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 5.61e-01 4.66e-02 7.48e-01
NRAGE signals death through JNK 53 5.58e-01 4.65e-02 7.45e-01
ATF6 (ATF6-alpha) activates chaperones 12 7.82e-01 4.61e-02 9.01e-01
Other interleukin signaling 18 7.35e-01 4.61e-02 8.76e-01
Signaling by NTRK3 (TRKC) 16 7.50e-01 -4.60e-02 8.81e-01
Integrin cell surface interactions 52 5.67e-01 4.59e-02 7.51e-01
NF-kB is activated and signals survival 12 7.84e-01 -4.57e-02 9.01e-01
Nervous system development 474 8.86e-02 -4.57e-02 2.34e-01
Class I MHC mediated antigen processing & presentation 349 1.43e-01 4.56e-02 3.31e-01
Alpha-protein kinase 1 signaling pathway 11 7.95e-01 -4.54e-02 9.04e-01
Insulin processing 21 7.20e-01 4.52e-02 8.64e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 7.09e-01 -4.50e-02 8.57e-01
Heparan sulfate/heparin (HS-GAG) metabolism 37 6.40e-01 4.44e-02 8.07e-01
Receptor-type tyrosine-protein phosphatases 12 7.91e-01 4.43e-02 9.04e-01
MET activates PTK2 signaling 15 7.68e-01 -4.40e-02 8.93e-01
HCMV Infection 96 4.59e-01 -4.37e-02 6.61e-01
Glutathione synthesis and recycling 10 8.11e-01 4.36e-02 9.07e-01
Amino acid transport across the plasma membrane 23 7.19e-01 4.33e-02 8.64e-01
ADORA2B mediated anti-inflammatory cytokines production 73 5.26e-01 -4.29e-02 7.16e-01
Synthesis of substrates in N-glycan biosythesis 58 5.72e-01 4.29e-02 7.54e-01
Laminin interactions 21 7.34e-01 4.29e-02 8.76e-01
Hemostasis 547 8.96e-02 4.24e-02 2.36e-01
Association of TriC/CCT with target proteins during biosynthesis 37 6.57e-01 -4.22e-02 8.21e-01
Signaling by FGFR3 31 6.85e-01 4.21e-02 8.37e-01
Signal Transduction 1882 3.05e-03 4.13e-02 1.84e-02
FRS-mediated FGFR1 signaling 14 7.93e-01 4.04e-02 9.04e-01
Depolymerisation of the Nuclear Lamina 15 7.87e-01 -4.03e-02 9.03e-01
PIP3 activates AKT signaling 239 2.92e-01 3.95e-02 5.03e-01
DNA Damage/Telomere Stress Induced Senescence 44 6.52e-01 -3.93e-02 8.17e-01
PKA activation 15 7.92e-01 3.93e-02 9.04e-01
SIRT1 negatively regulates rRNA expression 24 7.40e-01 -3.91e-02 8.79e-01
Senescence-Associated Secretory Phenotype (SASP) 66 5.86e-01 3.88e-02 7.65e-01
Nicotinamide salvaging 14 8.02e-01 3.87e-02 9.07e-01
Intracellular signaling by second messengers 271 2.73e-01 3.87e-02 4.82e-01
Cytosolic sensors of pathogen-associated DNA 62 5.98e-01 -3.87e-02 7.77e-01
cGMP effects 12 8.17e-01 3.86e-02 9.10e-01
Formation of Fibrin Clot (Clotting Cascade) 26 7.36e-01 3.82e-02 8.77e-01
PKA-mediated phosphorylation of CREB 17 7.86e-01 -3.81e-02 9.02e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 8.00e-01 -3.78e-02 9.07e-01
Heme biosynthesis 14 8.08e-01 3.75e-02 9.07e-01
Cell-cell junction organization 38 6.89e-01 -3.75e-02 8.41e-01
Diseases of metabolism 189 3.75e-01 3.75e-02 5.87e-01
Negative regulation of MAPK pathway 42 6.75e-01 3.73e-02 8.31e-01
Activation of NMDA receptors and postsynaptic events 58 6.23e-01 -3.73e-02 7.92e-01
Cyclin D associated events in G1 47 6.60e-01 -3.71e-02 8.21e-01
G1 Phase 47 6.60e-01 -3.71e-02 8.21e-01
Post NMDA receptor activation events 48 6.60e-01 -3.67e-02 8.21e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 7.96e-01 -3.62e-02 9.04e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 7.96e-01 -3.62e-02 9.04e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 7.90e-01 -3.62e-02 9.04e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 7.90e-01 -3.62e-02 9.04e-01
GPCR downstream signalling 493 1.70e-01 3.61e-02 3.62e-01
Maturation of nucleoprotein 10 8.44e-01 3.60e-02 9.28e-01
Cyclin A:Cdk2-associated events at S phase entry 85 5.66e-01 -3.60e-02 7.51e-01
HIV Transcription Initiation 45 6.77e-01 -3.59e-02 8.31e-01
RNA Polymerase II HIV Promoter Escape 45 6.77e-01 -3.59e-02 8.31e-01
RNA Polymerase II Promoter Escape 45 6.77e-01 -3.59e-02 8.31e-01
RNA Polymerase II Transcription Initiation 45 6.77e-01 -3.59e-02 8.31e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 6.77e-01 -3.59e-02 8.31e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 6.77e-01 -3.59e-02 8.31e-01
CaM pathway 27 7.47e-01 3.59e-02 8.79e-01
Calmodulin induced events 27 7.47e-01 3.59e-02 8.79e-01
Extra-nuclear estrogen signaling 67 6.13e-01 -3.57e-02 7.89e-01
Metabolism of vitamins and cofactors 155 4.43e-01 3.57e-02 6.45e-01
TNFR2 non-canonical NF-kB pathway 95 5.49e-01 -3.56e-02 7.37e-01
Transcriptional activation of mitochondrial biogenesis 51 6.61e-01 -3.55e-02 8.21e-01
Regulation of RUNX1 Expression and Activity 18 8.02e-01 -3.42e-02 9.07e-01
Diseases associated with N-glycosylation of proteins 17 8.13e-01 -3.31e-02 9.08e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 8.08e-01 3.31e-02 9.07e-01
TICAM1-dependent activation of IRF3/IRF7 12 8.43e-01 3.30e-02 9.28e-01
Signaling by ERBB4 44 7.05e-01 3.30e-02 8.55e-01
Nuclear signaling by ERBB4 24 7.80e-01 3.29e-02 9.00e-01
ECM proteoglycans 35 7.37e-01 3.28e-02 8.77e-01
Negative regulation of FGFR4 signaling 21 7.95e-01 3.28e-02 9.04e-01
Translation of structural proteins 28 7.64e-01 3.27e-02 8.91e-01
Adaptive Immune System 756 1.27e-01 -3.26e-02 3.04e-01
Regulation of APC/C activators between G1/S and early anaphase 79 6.18e-01 -3.25e-02 7.91e-01
Class A/1 (Rhodopsin-like receptors) 162 4.77e-01 -3.24e-02 6.76e-01
Signalling to RAS 19 8.07e-01 3.23e-02 9.07e-01
Elastic fibre formation 32 7.52e-01 3.23e-02 8.83e-01
DAP12 signaling 28 7.69e-01 -3.20e-02 8.93e-01
Disorders of Developmental Biology 12 8.49e-01 3.18e-02 9.28e-01
Disorders of Nervous System Development 12 8.49e-01 3.18e-02 9.28e-01
Loss of function of MECP2 in Rett syndrome 12 8.49e-01 3.18e-02 9.28e-01
Pervasive developmental disorders 12 8.49e-01 3.18e-02 9.28e-01
TCF dependent signaling in response to WNT 165 4.87e-01 3.14e-02 6.82e-01
Ion homeostasis 40 7.32e-01 3.13e-02 8.76e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 7.47e-01 3.11e-02 8.79e-01
Cleavage of the damaged pyrimidine 29 7.72e-01 -3.11e-02 8.93e-01
Depyrimidination 29 7.72e-01 -3.11e-02 8.93e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 7.72e-01 -3.11e-02 8.93e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 7.92e-01 3.11e-02 9.04e-01
Transcriptional Regulation by VENTX 38 7.41e-01 -3.10e-02 8.79e-01
APC/C-mediated degradation of cell cycle proteins 86 6.24e-01 -3.06e-02 7.92e-01
Regulation of mitotic cell cycle 86 6.24e-01 -3.06e-02 7.92e-01
Antimicrobial peptides 33 7.62e-01 3.04e-02 8.90e-01
Metabolism 1768 3.45e-02 3.03e-02 1.18e-01
RNA polymerase II transcribes snRNA genes 72 6.57e-01 3.03e-02 8.21e-01
Activation of kainate receptors upon glutamate binding 26 7.91e-01 3.00e-02 9.04e-01
Cholesterol biosynthesis 24 8.01e-01 2.97e-02 9.07e-01
Neurotransmitter release cycle 39 7.50e-01 2.95e-02 8.81e-01
Synthesis of very long-chain fatty acyl-CoAs 21 8.16e-01 2.93e-02 9.10e-01
Activation of HOX genes during differentiation 68 6.76e-01 2.93e-02 8.31e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 6.76e-01 2.93e-02 8.31e-01
Sulfur amino acid metabolism 23 8.08e-01 2.93e-02 9.07e-01
Constitutive Signaling by EGFRvIII 14 8.50e-01 2.92e-02 9.28e-01
Signaling by EGFRvIII in Cancer 14 8.50e-01 2.92e-02 9.28e-01
Insulin receptor signalling cascade 39 7.55e-01 2.89e-02 8.84e-01
Mitochondrial iron-sulfur cluster biogenesis 13 8.57e-01 -2.88e-02 9.34e-01
Initiation of Nuclear Envelope (NE) Reformation 19 8.28e-01 2.88e-02 9.17e-01
Signaling by NTRK2 (TRKB) 20 8.30e-01 -2.77e-02 9.18e-01
Purine salvage 12 8.68e-01 2.77e-02 9.36e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 8.19e-01 2.75e-02 9.10e-01
Factors involved in megakaryocyte development and platelet production 116 6.09e-01 2.75e-02 7.87e-01
Cellular Senescence 144 5.75e-01 2.71e-02 7.57e-01
Biosynthesis of DHA-derived SPMs 14 8.61e-01 -2.71e-02 9.35e-01
Regulation of FOXO transcriptional activity by acetylation 10 8.84e-01 2.66e-02 9.45e-01
Cyclin E associated events during G1/S transition 83 6.80e-01 -2.62e-02 8.34e-01
RIPK1-mediated regulated necrosis 29 8.08e-01 2.61e-02 9.07e-01
Regulated Necrosis 29 8.08e-01 2.61e-02 9.07e-01
Regulation of necroptotic cell death 29 8.08e-01 2.61e-02 9.07e-01
TNF signaling 43 7.71e-01 -2.56e-02 8.93e-01
ERBB2 Regulates Cell Motility 10 8.89e-01 -2.56e-02 9.48e-01
SARS-CoV Infections 139 6.07e-01 2.53e-02 7.86e-01
ESR-mediated signaling 162 5.83e-01 -2.50e-02 7.64e-01
Transcriptional Regulation by MECP2 47 7.67e-01 2.49e-02 8.93e-01
Post-translational protein modification 1189 1.55e-01 2.45e-02 3.44e-01
Cell-Cell communication 87 6.93e-01 -2.45e-02 8.44e-01
Class B/2 (Secretin family receptors) 56 7.54e-01 2.42e-02 8.84e-01
PI3K/AKT Signaling in Cancer 80 7.10e-01 -2.40e-02 8.58e-01
Base-Excision Repair, AP Site Formation 31 8.19e-01 -2.38e-02 9.10e-01
Downstream signaling events of B Cell Receptor (BCR) 79 7.15e-01 2.38e-02 8.61e-01
Signaling by WNT in cancer 30 8.22e-01 2.37e-02 9.12e-01
Disease 1350 1.48e-01 -2.35e-02 3.32e-01
Prostacyclin signalling through prostacyclin receptor 16 8.73e-01 2.31e-02 9.38e-01
Diseases associated with O-glycosylation of proteins 48 7.84e-01 -2.28e-02 9.01e-01
RNA Polymerase II Pre-transcription Events 78 7.28e-01 -2.28e-02 8.73e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 8.84e-01 -2.25e-02 9.45e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 8.84e-01 -2.25e-02 9.45e-01
Pyruvate metabolism 28 8.39e-01 2.22e-02 9.26e-01
Regulation of MECP2 expression and activity 28 8.39e-01 2.21e-02 9.26e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 9.06e-01 2.16e-02 9.57e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 8.12e-01 -2.12e-02 9.07e-01
HIV Transcription Elongation 42 8.12e-01 -2.12e-02 9.07e-01
Tat-mediated elongation of the HIV-1 transcript 42 8.12e-01 -2.12e-02 9.07e-01
Transcriptional regulation of pluripotent stem cells 19 8.74e-01 2.10e-02 9.39e-01
Signaling by ERBB2 44 8.10e-01 -2.09e-02 9.07e-01
Keratan sulfate biosynthesis 22 8.69e-01 -2.03e-02 9.36e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 6.75e-01 -2.00e-02 8.31e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 7.59e-01 2.00e-02 8.86e-01
PECAM1 interactions 12 9.06e-01 1.97e-02 9.57e-01
Interleukin-7 signaling 21 8.76e-01 -1.96e-02 9.41e-01
Regulation of localization of FOXO transcription factors 11 9.11e-01 1.95e-02 9.59e-01
Antigen processing: Ubiquitination & Proteasome degradation 288 5.70e-01 -1.95e-02 7.54e-01
Lewis blood group biosynthesis 13 9.05e-01 -1.91e-02 9.57e-01
HS-GAG biosynthesis 20 8.83e-01 1.90e-02 9.45e-01
Pexophagy 11 9.14e-01 1.89e-02 9.59e-01
Acyl chain remodelling of PS 14 9.03e-01 -1.89e-02 9.57e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 8.69e-01 -1.83e-02 9.36e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 8.69e-01 -1.83e-02 9.36e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 8.19e-01 1.81e-02 9.10e-01
Hedgehog ‘off’ state 92 7.64e-01 1.81e-02 8.91e-01
HIV elongation arrest and recovery 32 8.61e-01 1.78e-02 9.35e-01
Pausing and recovery of HIV elongation 32 8.61e-01 1.78e-02 9.35e-01
DAG and IP3 signaling 33 8.60e-01 1.78e-02 9.35e-01
Ephrin signaling 17 9.01e-01 -1.75e-02 9.57e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 13 9.13e-01 -1.74e-02 9.59e-01
NRIF signals cell death from the nucleus 15 9.08e-01 1.72e-02 9.58e-01
HCMV Late Events 69 8.09e-01 -1.68e-02 9.07e-01
Cell junction organization 59 8.23e-01 -1.68e-02 9.13e-01
Downstream signal transduction 27 8.81e-01 1.67e-02 9.44e-01
Developmental Biology 727 4.53e-01 -1.64e-02 6.56e-01
Cell-extracellular matrix interactions 14 9.17e-01 1.60e-02 9.60e-01
IL-6-type cytokine receptor ligand interactions 12 9.24e-01 -1.59e-02 9.65e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 8.17e-01 1.58e-02 9.10e-01
p75NTR recruits signalling complexes 12 9.25e-01 1.57e-02 9.65e-01
Packaging Of Telomere Ends 20 9.04e-01 1.56e-02 9.57e-01
STING mediated induction of host immune responses 15 9.17e-01 -1.55e-02 9.60e-01
Negative regulation of the PI3K/AKT network 87 8.03e-01 -1.55e-02 9.07e-01
Diseases of glycosylation 108 7.82e-01 1.54e-02 9.01e-01
Deubiquitination 241 6.83e-01 1.53e-02 8.36e-01
Receptor Mediated Mitophagy 11 9.30e-01 1.52e-02 9.68e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 8.71e-01 -1.52e-02 9.37e-01
SHC1 events in ERBB4 signaling 10 9.34e-01 -1.51e-02 9.68e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 8.64e-01 -1.50e-02 9.35e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 8.27e-01 1.49e-02 9.17e-01
Signaling by FGFR 69 8.33e-01 -1.47e-02 9.20e-01
G alpha (q) signalling events 131 7.76e-01 1.44e-02 8.96e-01
Signaling by EGFR in Cancer 23 9.06e-01 -1.41e-02 9.57e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 8.35e-01 1.39e-02 9.22e-01
FOXO-mediated transcription 58 8.55e-01 -1.38e-02 9.33e-01
Nitric oxide stimulates guanylate cyclase 15 9.27e-01 -1.37e-02 9.66e-01
Circadian Clock 67 8.48e-01 -1.35e-02 9.28e-01
Protein-protein interactions at synapses 57 8.60e-01 1.35e-02 9.35e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 8.43e-01 1.34e-02 9.28e-01
Formation of the Early Elongation Complex 33 8.94e-01 1.34e-02 9.51e-01
Formation of the HIV-1 Early Elongation Complex 33 8.94e-01 1.34e-02 9.51e-01
NGF-stimulated transcription 31 8.98e-01 1.33e-02 9.54e-01
Disorders of transmembrane transporters 147 7.87e-01 1.29e-02 9.03e-01
Ub-specific processing proteases 170 7.74e-01 -1.28e-02 8.94e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 9.35e-01 1.26e-02 9.68e-01
Signaling by FGFR4 31 9.06e-01 1.22e-02 9.57e-01
Glycolysis 67 8.65e-01 1.20e-02 9.35e-01
Protein ubiquitination 72 8.64e-01 -1.17e-02 9.35e-01
FLT3 Signaling 244 7.53e-01 1.17e-02 8.83e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 74 8.63e-01 1.16e-02 9.35e-01
Interleukin-4 and Interleukin-13 signaling 92 8.49e-01 1.15e-02 9.28e-01
Cristae formation 31 9.14e-01 1.13e-02 9.59e-01
Pausing and recovery of Tat-mediated HIV elongation 30 9.15e-01 1.12e-02 9.60e-01
Tat-mediated HIV elongation arrest and recovery 30 9.15e-01 1.12e-02 9.60e-01
Peptide ligand-binding receptors 92 8.54e-01 1.11e-02 9.32e-01
Negative regulation of FGFR2 signaling 23 9.27e-01 -1.11e-02 9.66e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 9.19e-01 -1.08e-02 9.60e-01
Visual phototransduction 59 8.86e-01 1.07e-02 9.46e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 9.32e-01 1.07e-02 9.68e-01
Signaling by PDGFR in disease 19 9.36e-01 -1.07e-02 9.68e-01
Cytokine Signaling in Immune system 735 6.25e-01 1.06e-02 7.92e-01
Purine catabolism 16 9.42e-01 1.05e-02 9.71e-01
Formation of the beta-catenin:TCF transactivating complex 46 9.05e-01 -1.01e-02 9.57e-01
GPCR ligand binding 229 7.96e-01 -9.91e-03 9.04e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 8.93e-01 9.77e-03 9.51e-01
p75NTR signals via NF-kB 15 9.49e-01 -9.51e-03 9.75e-01
Activation of RAC1 11 9.57e-01 9.49e-03 9.80e-01
Signaling by Nuclear Receptors 218 8.11e-01 -9.41e-03 9.07e-01
Intrinsic Pathway of Fibrin Clot Formation 16 9.49e-01 -9.28e-03 9.75e-01
Diseases associated with glycosaminoglycan metabolism 26 9.36e-01 9.15e-03 9.68e-01
Constitutive Signaling by Overexpressed ERBB2 11 9.60e-01 -8.78e-03 9.81e-01
Acyl chain remodelling of PE 20 9.47e-01 8.65e-03 9.74e-01
Peptide hormone metabolism 51 9.18e-01 -8.38e-03 9.60e-01
TRP channels 17 9.52e-01 8.36e-03 9.77e-01
MAPK1/MAPK3 signaling 235 8.45e-01 7.39e-03 9.28e-01
Potential therapeutics for SARS 77 9.12e-01 -7.32e-03 9.59e-01
Signaling by PDGF 44 9.36e-01 6.99e-03 9.68e-01
Interferon gamma signaling 83 9.13e-01 6.96e-03 9.59e-01
Downstream signaling of activated FGFR1 20 9.57e-01 6.93e-03 9.80e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 9.69e-01 -6.84e-03 9.87e-01
Intrinsic Pathway for Apoptosis 52 9.33e-01 6.77e-03 9.68e-01
Ovarian tumor domain proteases 37 9.44e-01 -6.72e-03 9.71e-01
Synthesis of PA 32 9.51e-01 -6.22e-03 9.77e-01
G alpha (i) signalling events 243 8.70e-01 6.10e-03 9.37e-01
MAPK family signaling cascades 269 8.64e-01 6.05e-03 9.35e-01
RAF/MAP kinase cascade 230 8.78e-01 5.88e-03 9.41e-01
Regulation of PTEN gene transcription 59 9.39e-01 -5.74e-03 9.70e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 9.66e-01 5.69e-03 9.85e-01
Formation of RNA Pol II elongation complex 57 9.41e-01 5.68e-03 9.70e-01
RNA Polymerase II Transcription Elongation 57 9.41e-01 5.68e-03 9.70e-01
Interleukin-2 signaling 11 9.75e-01 -5.42e-03 9.87e-01
Mitochondrial biogenesis 88 9.32e-01 -5.28e-03 9.68e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 9.60e-01 -4.80e-03 9.81e-01
O-linked glycosylation 83 9.40e-01 -4.74e-03 9.70e-01
Ca2+ pathway 57 9.56e-01 -4.25e-03 9.79e-01
AMER1 mutants destabilize the destruction complex 14 9.79e-01 4.02e-03 9.87e-01
APC truncation mutants have impaired AXIN binding 14 9.79e-01 4.02e-03 9.87e-01
AXIN missense mutants destabilize the destruction complex 14 9.79e-01 4.02e-03 9.87e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 9.79e-01 4.02e-03 9.87e-01
Truncations of AMER1 destabilize the destruction complex 14 9.79e-01 4.02e-03 9.87e-01
truncated APC mutants destabilize the destruction complex 14 9.79e-01 4.02e-03 9.87e-01
Condensation of Prophase Chromosomes 29 9.70e-01 -3.98e-03 9.87e-01
Leishmania infection 245 9.28e-01 -3.34e-03 9.67e-01
HS-GAG degradation 16 9.82e-01 -3.20e-03 9.88e-01
Interferon alpha/beta signaling 57 9.67e-01 -3.15e-03 9.86e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 9.62e-01 3.07e-03 9.82e-01
Cleavage of the damaged purine 24 9.80e-01 -3.02e-03 9.87e-01
Depurination 24 9.80e-01 -3.02e-03 9.87e-01
Recognition and association of DNA glycosylase with site containing an affected purine 24 9.80e-01 -3.02e-03 9.87e-01
Inhibition of DNA recombination at telomere 35 9.76e-01 -2.88e-03 9.87e-01
Unfolded Protein Response (UPR) 86 9.75e-01 1.92e-03 9.87e-01
Signaling by FGFR in disease 50 9.83e-01 1.79e-03 9.88e-01
Neddylation 218 9.69e-01 1.52e-03 9.87e-01
Metabolism of water-soluble vitamins and cofactors 109 9.80e-01 -1.42e-03 9.87e-01
RAF-independent MAPK1/3 activation 21 9.92e-01 1.28e-03 9.96e-01
E3 ubiquitin ligases ubiquitinate target proteins 52 9.89e-01 -1.06e-03 9.94e-01
VEGFR2 mediated cell proliferation 18 9.95e-01 8.48e-04 9.97e-01
TP53 Regulates Transcription of Cell Death Genes 42 9.93e-01 7.83e-04 9.96e-01
Transcriptional regulation by RUNX1 184 9.87e-01 -6.87e-04 9.92e-01
Assembly of the pre-replicative complex 66 9.96e-01 -3.75e-04 9.97e-01
PI-3K cascade:FGFR1 12 9.99e-01 2.62e-04 9.99e-01
Synthesis of PIPs at the early endosome membrane 16 1.00e+00 -5.78e-05 1.00e+00


Detailed Gene set reports



IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)
512
set IRAK4 deficiency (TLR2/4)
setSize 10
pANOVA 6.62e-06
s.dist 0.823
p.adjustANOVA 0.000114



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
TLR2 10761
CD14 10542
LY96 10002
TLR4 9355
TLR1 8749
TLR6 7631
TIRAP 6862

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
TLR2 10761
CD14 10542
LY96 10002
TLR4 9355
TLR1 8749
TLR6 7631
TIRAP 6862


MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)
685
set MyD88 deficiency (TLR2/4)
setSize 10
pANOVA 6.62e-06
s.dist 0.823
p.adjustANOVA 0.000114



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
TLR2 10761
CD14 10542
LY96 10002
TLR4 9355
TLR1 8749
TLR6 7631
TIRAP 6862

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
TLR2 10761
CD14 10542
LY96 10002
TLR4 9355
TLR1 8749
TLR6 7631
TIRAP 6862


Peptide chain elongation

Peptide chain elongation
807
set Peptide chain elongation
setSize 88
pANOVA 2.46e-30
s.dist -0.705
p.adjustANOVA 3.72e-28



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
EEF1A1 -9389
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
EEF1A1 -9389
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
EEF2 -7073
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
RPL28 -1952
UBA52 -1437
FAU -1029
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
RPL3L 5700
RPL26L1 6187


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
350
set Eukaryotic Translation Elongation
setSize 93
pANOVA 7.89e-32
s.dist -0.703
p.adjustANOVA 1.34e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
EEF1A1 -9389
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
EEF1B2 -9090
RPL4 -9065
EEF1G -8961
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
EEF1A1 -9389
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
EEF1B2 -9090
RPL4 -9065
EEF1G -8961
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
EEF2 -7073
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
EEF1A1P5 -6596
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
EEF1D -4995
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
RPL28 -1952
EEF1A2 -1947
UBA52 -1437
FAU -1029
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
RPL3L 5700
RPL26L1 6187


Selenocysteine synthesis

Selenocysteine synthesis
1060
set Selenocysteine synthesis
setSize 92
pANOVA 9.58e-30
s.dist -0.682
p.adjustANOVA 1.1e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
SEPSECS -7064
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
SARS1 -6425
RPL36 -6343
RPL8 -6274
SECISBP2 -6069
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
EEFSEC -5238
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
PSTK -3075
RPL28 -1952
UBA52 -1437
FAU -1029
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
RPL3L 5700
RPL26L1 6187
SEPHS2 7242


Viral mRNA Translation

Viral mRNA Translation
1315
set Viral mRNA Translation
setSize 88
pANOVA 1.67e-28
s.dist -0.682
p.adjustANOVA 1.62e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
GRSF1 -3125
RPL28 -1952
UBA52 -1437
FAU -1029
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
RPL3L 5700
RPL26L1 6187
DNAJC3 8291


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
392
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 5.67e-32
s.dist -0.68
p.adjustANOVA 1.1e-29



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
EIF3L -7766
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
EIF3J -6001
EIF3H -5894
RPL39 -5790
EIF3M -5620
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
EIF3D -4337
RPL36AL -4148
RPLP1 -3887
EIF3C -3750
EIF3F -3748
EIF3I -2671
RPL28 -1952
EIF3G -1676
EIF3A -1537
UBA52 -1437
FAU -1029
EIF3K -298
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
RPL3L 5700
RPL26L1 6187


Eukaryotic Translation Termination

Eukaryotic Translation Termination
352
set Eukaryotic Translation Termination
setSize 92
pANOVA 2.59e-29
s.dist -0.677
p.adjustANOVA 2.72e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
N6AMT1 -8889
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
N6AMT1 -8889
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
GSPT2 -8336
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
GSPT1 -6576
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
RPL28 -1952
UBA52 -1437
FAU -1029
TRMT112 -370
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
ETF1 4300
APEH 4454
RPL3L 5700
RPL26L1 6187


Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse
1278
set Translocation of ZAP-70 to Immunological synapse
setSize 24
pANOVA 1.86e-08
s.dist -0.663
p.adjustANOVA 5.9e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
CD3G -9125
HLA-DQB2 -9021
CD3D -8747
TRBC1 -8666
ZAP70 -8662
TRAV29DV5 -8326
TRAV8-4 -7607
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
HLA-DPA1 -5854
CD4 -4882
HLA-DQA1 -1465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
CD3G -9125
HLA-DQB2 -9021
CD3D -8747
TRBC1 -8666
ZAP70 -8662
TRAV29DV5 -8326
TRAV8-4 -7607
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
HLA-DPA1 -5854
CD4 -4882
HLA-DQA1 -1465
HLA-DRB5 -1119
HLA-DRB1 1353
HLA-DQB1 3660
PTPN22 5604


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
743
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 3.69e-28
s.dist -0.656
p.adjustANOVA 3.35e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
GSPT2 -8336
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
NCBP2 -8212
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
GSPT1 -6576
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
PABPC1 -3482
RPL28 -1952
UBA52 -1437
NCBP1 -1125
FAU -1029
RPL39L -69
RPS4Y1 1461
RPS9 2392
RPS27L 2784
ETF1 4300
RPL3L 5700
RPL26L1 6187
UPF1 6979
EIF4G1 9922


alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
1330
set alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize 12
pANOVA 0.000131
s.dist 0.637
p.adjustANOVA 0.00152



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAA1 11576
ACOT8 10812
ACSL1 10810
ELOVL1 10305
FADS1 10296
HSD17B4 9667
ELOVL3 9628
ACOX1 8434
ABCD1 6135
FADS2 5662
ELOVL5 2295
SCP2 -1758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAA1 11576
ACOT8 10812
ACSL1 10810
ELOVL1 10305
FADS1 10296
HSD17B4 9667
ELOVL3 9628
ACOX1 8434
ABCD1 6135
FADS2 5662
ELOVL5 2295
SCP2 -1758


alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
1331
set alpha-linolenic acid (ALA) metabolism
setSize 12
pANOVA 0.000131
s.dist 0.637
p.adjustANOVA 0.00152



Top enriched genes

Top 20 genes
GeneID Gene Rank
ACAA1 11576
ACOT8 10812
ACSL1 10810
ELOVL1 10305
FADS1 10296
HSD17B4 9667
ELOVL3 9628
ACOX1 8434
ABCD1 6135
FADS2 5662
ELOVL5 2295
SCP2 -1758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ACAA1 11576
ACOT8 10812
ACSL1 10810
ELOVL1 10305
FADS1 10296
HSD17B4 9667
ELOVL3 9628
ACOX1 8434
ABCD1 6135
FADS2 5662
ELOVL5 2295
SCP2 -1758


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1007
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 9.21e-28
s.dist -0.631
p.adjustANOVA 6.61e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
IMPACT -6768
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
GCN1 -6541
RPS28 -6429
RPL36 -6343
RPL8 -6274
ASNS -6196
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
ATF2 -4941
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
EIF2S1 -3350
ATF3 -2894
RPL28 -1952
EIF2AK4 -1601
UBA52 -1437
TRIB3 -1365
FAU -1029
ATF4 -994
RPL39L -69
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
CEBPG 1958
RPS9 2392
RPS27L 2784
DDIT3 3500
RPL3L 5700
RPL26L1 6187
CEBPB 11028


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
588
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 9.65e-30
s.dist -0.624
p.adjustANOVA 1.1e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
EIF3L -7766
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
EIF3J -6001
EIF3H -5894
RPL39 -5790
EIF3M -5620
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
EIF3D -4337
RPL36AL -4148
RPLP1 -3887
EIF3C -3750
EIF3F -3748
PABPC1 -3482
EIF2S1 -3350
EIF3I -2671
RPL28 -1952
EIF3G -1676
EIF3A -1537
UBA52 -1437
FAU -1029
EIF3K -298
RPL39L -69
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF4E 2104
RPS9 2392
RPS27L 2784
RPL3L 5700
EIF4A1 5928
RPL26L1 6187
EIF4H 7435
EIF4G1 9922


Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand
967
set Regulation of TLR by endogenous ligand
setSize 11
pANOVA 0.000345
s.dist 0.623
p.adjustANOVA 0.00313



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A9 11432
CD36 11354
S100A8 11315
TLR2 10761
CD14 10542
LY96 10002
TLR4 9355
TLR1 8749
TLR6 7631
S100A1 892
HMGB1 -7684

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A9 11432
CD36 11354
S100A8 11315
TLR2 10761
CD14 10542
LY96 10002
TLR4 9355
TLR1 8749
TLR6 7631
S100A1 892
HMGB1 -7684


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
434
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 8.89e-30
s.dist -0.622
p.adjustANOVA 1.1e-27



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
EIF3L -7766
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
EIF3J -6001
EIF5B -5931
EIF3H -5894
RPL39 -5790
EIF3M -5620
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPL37A -4774
RPSA -4559
EIF3D -4337
RPL36AL -4148
RPLP1 -3887
EIF3C -3750
EIF3F -3748
EIF2S1 -3350
EIF3I -2671
RPL28 -1952
EIF3G -1676
EIF3A -1537
UBA52 -1437
FAU -1029
EIF5 -416
EIF3K -298
RPL39L -69
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF4E 2104
RPS9 2392
RPS27L 2784
RPL3L 5700
EIF4A1 5928
RPL26L1 6187
EIF4H 7435
EIF4G1 9922


Unwinding of DNA

Unwinding of DNA
1304
set Unwinding of DNA
setSize 12
pANOVA 0.000211
s.dist -0.618
p.adjustANOVA 0.00215



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -9769
MCM6 -9297
GINS4 -8200
MCM7 -7720
MCM4 -7627
MCM2 -7557
MCM8 -6138
CDC45 -5643
GINS3 -3998
GINS2 -3279
GINS1 -976
MCM5 1277

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -9769
MCM6 -9297
GINS4 -8200
MCM7 -7720
MCM4 -7627
MCM2 -7557
MCM8 -6138
CDC45 -5643
GINS3 -3998
GINS2 -3279
GINS1 -976
MCM5 1277


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
398
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 2.8e-14
s.dist -0.615
p.adjustANOVA 1.31e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS2 -9635
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766
RPS4X -7636
RPS10 -7629

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS2 -9635
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766
RPS4X -7636
RPS10 -7629
RPS16 -7617
RPS13 -7375
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPS28 -6429
EIF3J -6001
EIF3H -5894
EIF3M -5620
RPS19 -5616
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPSA -4559
EIF3D -4337
EIF3C -3750
EIF3F -3748
EIF2S1 -3350
EIF3I -2671
EIF3G -1676
EIF3A -1537
FAU -1029
EIF3K -298
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
RPS9 2392
RPS27L 2784


Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
625
set Major pathway of rRNA processing in the nucleolus and cytosol
setSize 180
pANOVA 3.41e-43
s.dist -0.594
p.adjustANOVA 1.16e-40



Top enriched genes

Top 20 genes
GeneID Gene Rank
TSR1 -9723
NOP14 -9719
RPL3 -9701
FBL -9671
RPS2 -9635
RPP40 -9619
RPL14 -9390
RPL23A -9382
GNL3 -9380
NOP58 -9366
RPL5 -9359
NOL11 -9354
UTP4 -9338
RPS3A -9257
NOB1 -9253
WDR75 -9213
RPS6 -9170
NCL -9167
BMS1 -9164
RPL7 -9134

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TSR1 -9723
NOP14 -9719
RPL3 -9701
FBL -9671
RPS2 -9635
RPP40 -9619
RPL14 -9390
RPL23A -9382
GNL3 -9380
NOP58 -9366
RPL5 -9359
NOL11 -9354
UTP4 -9338
RPS3A -9257
NOB1 -9253
WDR75 -9213
RPS6 -9170
NCL -9167
BMS1 -9164
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
WDR43 -8851
RPS25 -8832
RPL21 -8773
TEX10 -8744
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
LAS1L -8501
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RIOK2 -8405
RPS12 -8401
NOP56 -8346
RPS14 -8337
RPS23 -8334
RPL10 -8318
UTP15 -8280
EXOSC5 -8271
RPS27 -8260
RPLP2 -8255
IMP4 -8233
EXOSC2 -8172
RPL36A -8130
NIP7 -8124
RRP9 -8121
RPS7 -8047
RPL35A -8046
RPL10A -7989
SNU13 -7987
EXOSC6 -7982
PDCD11 -7980
WDR3 -7973
DDX47 -7962
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
EXOSC8 -7905
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RCL1 -7761
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPP25 -7624
RPS16 -7617
RPL18A -7609
CSNK1E -7527
RPL31 -7521
PNO1 -7506
EXOSC9 -7477
RPL9 -7451
RPL15 -7380
RPS13 -7375
HEATR1 -7360
PELP1 -7329
RPL7A -7296
RPS18 -7288
PWP2 -7199
NOL9 -7193
RPP30 -7173
RPS8 -7161
RPS17 -7134
RPL19 -7006
IMP3 -6997
WDR46 -6977
NOL6 -6945
RPL23 -6933
UTP20 -6898
EBNA1BP2 -6864
RPS29 -6791
RPS11 -6742
EMG1 -6735
RPS21 -6706
RPL37 -6660
MPHOSPH10 -6590
RPL38 -6589
EXOSC7 -6585
RPP38 -6534
KRR1 -6432
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
BYSL -5863
WDR36 -5853
RBM28 -5810
RPL39 -5790
DHX37 -5761
RPS19 -5616
RPL13 -5550
RPS26 -5524
PES1 -5491
UTP6 -5444
RPS15 -5342
RPS24 -5310
BOP1 -5141
EXOSC10 -5112
RPL37A -4774
MTREX -4734
LTV1 -4592
RRP7A -4574
RPSA -4559
WDR18 -4348
DCAF13 -4245
RPL36AL -4148
DIS3 -3916
RPLP1 -3887
DDX21 -3746
RIOK1 -3329
UTP14A -3160
FCF1 -3010
RPP14 -2433
MPHOSPH6 -2335
RPL28 -1952
UTP14C -1630
UTP3 -1460
UBA52 -1437
WDR12 -1301
FAU -1029
RPP21 -200
RPL39L -69
ISG20L2 -43
TBL3 55
EXOSC3 280
RRP36 511
C1D 531
RRP1 874
UTP11 1268
RPS4Y1 1461
DDX52 1503
ERI1 1991
RPS9 2392
EXOSC1 2569
RIOK3 2755
RPS27L 2784
FTSJ3 3515
UTP18 3740
DDX49 4194
SENP3 4233
RPL3L 5700
NOL12 5766
RPL26L1 6187
CSNK1D 7458
NOC4L 7461
EXOSC4 8895
XRN2 9350
SNORD3A 11429


rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
1355
set rRNA processing in the nucleus and cytosol
setSize 190
pANOVA 6.06e-45
s.dist -0.59
p.adjustANOVA 8.26e-42



Top enriched genes

Top 20 genes
GeneID Gene Rank
DKC1 -9835
TSR1 -9723
NOP14 -9719
RPL3 -9701
FBL -9671
RPS2 -9635
RPP40 -9619
RPL14 -9390
RPL23A -9382
GNL3 -9380
NOP58 -9366
RPL5 -9359
NOL11 -9354
UTP4 -9338
NAT10 -9326
THUMPD1 -9311
RPS3A -9257
NOB1 -9253
DIMT1 -9230
WDR75 -9213

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DKC1 -9835
TSR1 -9723
NOP14 -9719
RPL3 -9701
FBL -9671
RPS2 -9635
RPP40 -9619
RPL14 -9390
RPL23A -9382
GNL3 -9380
NOP58 -9366
RPL5 -9359
NOL11 -9354
UTP4 -9338
NAT10 -9326
THUMPD1 -9311
RPS3A -9257
NOB1 -9253
DIMT1 -9230
WDR75 -9213
RPS6 -9170
NCL -9167
BMS1 -9164
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
WDR43 -8851
RPS25 -8832
RPL21 -8773
TEX10 -8744
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
LAS1L -8501
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RIOK2 -8405
RPS12 -8401
NOP56 -8346
RPS14 -8337
RPS23 -8334
RPL10 -8318
UTP15 -8280
EXOSC5 -8271
RPS27 -8260
RPLP2 -8255
IMP4 -8233
EXOSC2 -8172
RPL36A -8130
NIP7 -8124
RRP9 -8121
RPS7 -8047
RPL35A -8046
RPL10A -7989
SNU13 -7987
EXOSC6 -7982
PDCD11 -7980
WDR3 -7973
DDX47 -7962
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
EXOSC8 -7905
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RCL1 -7761
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPP25 -7624
RPS16 -7617
RPL18A -7609
CSNK1E -7527
RPL31 -7521
PNO1 -7506
EXOSC9 -7477
RPL9 -7451
RPL15 -7380
RPS13 -7375
HEATR1 -7360
PELP1 -7329
RPL7A -7296
RPS18 -7288
PWP2 -7199
NOL9 -7193
RPP30 -7173
RPS8 -7161
RPS17 -7134
RPL19 -7006
IMP3 -6997
WDR46 -6977
NOL6 -6945
RPL23 -6933
UTP20 -6898
EBNA1BP2 -6864
RPS29 -6791
RPS11 -6742
EMG1 -6735
RPS21 -6706
GAR1 -6696
RPL37 -6660
MPHOSPH10 -6590
RPL38 -6589
EXOSC7 -6585
RPP38 -6534
KRR1 -6432
RPS28 -6429
RPL36 -6343
NOP2 -6275
RPL8 -6274
RPL27 -6068
RPL41 -6065
BYSL -5863
WDR36 -5853
RBM28 -5810
RPL39 -5790
DHX37 -5761
NHP2 -5747
RPS19 -5616
RPL13 -5550
RPS26 -5524
PES1 -5491
UTP6 -5444
RPS15 -5342
RPS24 -5310
BOP1 -5141
EXOSC10 -5112
RPL37A -4774
MTREX -4734
LTV1 -4592
RRP7A -4574
RPSA -4559
WDR18 -4348
DCAF13 -4245
RPL36AL -4148
DIS3 -3916
RPLP1 -3887
DDX21 -3746
RIOK1 -3329
UTP14A -3160
FCF1 -3010
RPP14 -2433
MPHOSPH6 -2335
RPL28 -1952
UTP14C -1630
UTP3 -1460
UBA52 -1437
WDR12 -1301
FAU -1029
TRMT112 -370
TSR3 -358
RPP21 -200
RPL39L -69
ISG20L2 -43
TBL3 55
EXOSC3 280
RRP36 511
C1D 531
RRP1 874
UTP11 1268
RPS4Y1 1461
DDX52 1503
ERI1 1991
RPS9 2392
EXOSC1 2569
RIOK3 2755
RPS27L 2784
FTSJ3 3515
UTP18 3740
DDX49 4194
SENP3 4233
RPL3L 5700
NOL12 5766
RPL26L1 6187
CSNK1D 7458
NOC4L 7461
EXOSC4 8895
XRN2 9350
NOP10 10793
SNORD3A 11429


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
142
set Cap-dependent Translation Initiation
setSize 118
pANOVA 5.14e-28
s.dist -0.584
p.adjustANOVA 3.89e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
EIF3L -7766
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
EIF3J -6001
EIF5B -5931
EIF3H -5894
RPL39 -5790
EIF3M -5620
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
EIF2B3 -4898
RPL37A -4774
RPSA -4559
EIF3D -4337
RPL36AL -4148
RPLP1 -3887
EIF3C -3750
EIF3F -3748
PABPC1 -3482
EIF2S1 -3350
EIF3I -2671
EIF2B5 -2425
RPL28 -1952
EIF3G -1676
EIF3A -1537
UBA52 -1437
FAU -1029
EIF5 -416
EIF3K -298
RPL39L -69
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF2B1 1607
EIF4E 2104
RPS9 2392
RPS27L 2784
EIF2B2 5069
EIF4EBP1 5335
RPL3L 5700
EIF4A1 5928
RPL26L1 6187
EIF2B4 6686
EIF4H 7435
EIF4G1 9922


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
351
set Eukaryotic Translation Initiation
setSize 118
pANOVA 5.14e-28
s.dist -0.584
p.adjustANOVA 3.89e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
EIF3L -7766
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
EIF3J -6001
EIF5B -5931
EIF3H -5894
RPL39 -5790
EIF3M -5620
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
EIF2B3 -4898
RPL37A -4774
RPSA -4559
EIF3D -4337
RPL36AL -4148
RPLP1 -3887
EIF3C -3750
EIF3F -3748
PABPC1 -3482
EIF2S1 -3350
EIF3I -2671
EIF2B5 -2425
RPL28 -1952
EIF3G -1676
EIF3A -1537
UBA52 -1437
FAU -1029
EIF5 -416
EIF3K -298
RPL39L -69
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF2B1 1607
EIF4E 2104
RPS9 2392
RPS27L 2784
EIF2B2 5069
EIF4EBP1 5335
RPL3L 5700
EIF4A1 5928
RPL26L1 6187
EIF2B4 6686
EIF4H 7435
EIF4G1 9922


Activation of the pre-replicative complex

Activation of the pre-replicative complex
50
set Activation of the pre-replicative complex
setSize 32
pANOVA 1.2e-08
s.dist -0.582
p.adjustANOVA 3.89e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -9769
POLA1 -9660
RPA1 -9657
MCM6 -9297
POLE3 -8924
DBF4 -8484
PRIM1 -8268
ORC2 -8097
ORC5 -8089
RPA3 -8069
MCM7 -7720
MCM4 -7627
ORC3 -7568
MCM2 -7557
MCM10 -6777
POLE2 -6659
POLA2 -6222
MCM8 -6138
ORC4 -5692
PRIM2 -5653

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -9769
POLA1 -9660
RPA1 -9657
MCM6 -9297
POLE3 -8924
DBF4 -8484
PRIM1 -8268
ORC2 -8097
ORC5 -8089
RPA3 -8069
MCM7 -7720
MCM4 -7627
ORC3 -7568
MCM2 -7557
MCM10 -6777
POLE2 -6659
POLA2 -6222
MCM8 -6138
ORC4 -5692
PRIM2 -5653
CDC45 -5643
CDC6 -5479
ORC1 -5158
RPA2 -4620
CDT1 -4032
CDK2 -3694
POLE -1479
POLE4 -1186
CDC7 815
MCM5 1277
GMNN 5280
ORC6 8542


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
1323
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 11
pANOVA 0.00104
s.dist 0.571
p.adjustANOVA 0.00786



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2A1 11707
FZD5 11699
AP2A2 10434
AP2S1 9504
CLTC 9346
CLTB 8275
CLTA 7680
AP2M1 7323
FZD2 3981
ROR1 1902
AP2B1 -3690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2A1 11707
FZD5 11699
AP2A2 10434
AP2S1 9504
CLTC 9346
CLTB 8275
CLTA 7680
AP2M1 7323
FZD2 3981
ROR1 1902
AP2B1 -3690


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
742
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 1.01e-25
s.dist -0.568
p.adjustANOVA 5.96e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
GSPT2 -8336
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
NCBP2 -8212
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
UPF3A -7835
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
DCP1A -7356
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RNPS1 -7032
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
GSPT1 -6576
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
PNRC2 -5116
RPL37A -4774
RPSA -4559
SMG6 -4443
RPL36AL -4148
MAGOHB -4045
RPLP1 -3887
PABPC1 -3482
UPF3B -3065
RBM8A -2980
RPL28 -1952
MAGOH -1931
SMG5 -1876
SMG1 -1661
UBA52 -1437
PPP2R2A -1333
NCBP1 -1125
FAU -1029
EIF4A3 -915
UPF2 -229
RPL39L -69
SMG8 663
RPS4Y1 1461
RPS9 2392
RPS27L 2784
ETF1 4300
PPP2R1A 4593
PPP2CA 4882
RPL3L 5700
RPL26L1 6187
UPF1 6979
CASC3 7085
SMG9 9218
SMG7 9427
EIF4G1 9922


Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
744
set Nonsense-Mediated Decay (NMD)
setSize 114
pANOVA 1.01e-25
s.dist -0.568
p.adjustANOVA 5.96e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
GSPT2 -8336
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
NCBP2 -8212
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
UPF3A -7835
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
DCP1A -7356
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RNPS1 -7032
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
GSPT1 -6576
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
PNRC2 -5116
RPL37A -4774
RPSA -4559
SMG6 -4443
RPL36AL -4148
MAGOHB -4045
RPLP1 -3887
PABPC1 -3482
UPF3B -3065
RBM8A -2980
RPL28 -1952
MAGOH -1931
SMG5 -1876
SMG1 -1661
UBA52 -1437
PPP2R2A -1333
NCBP1 -1125
FAU -1029
EIF4A3 -915
UPF2 -229
RPL39L -69
SMG8 663
RPS4Y1 1461
RPS9 2392
RPS27L 2784
ETF1 4300
PPP2R1A 4593
PPP2CA 4882
RPL3L 5700
RPL26L1 6187
UPF1 6979
CASC3 7085
SMG9 9218
SMG7 9427
EIF4G1 9922


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1040
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 1.26e-24
s.dist -0.562
p.adjustANOVA 6.59e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
SRPRB -8515
RPL6 -8498

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
SRPRB -8515
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
TRAM1 -7911
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
RPL27 -6068
RPL41 -6065
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
SEC11C -5303
SRP72 -4824
RPL37A -4774
RPSA -4559
SRP9 -4398
RPL36AL -4148
RPLP1 -3887
SEC61A2 -3262
SSR1 -2645
SRP68 -2562
SPCS2 -2449
SSR2 -2362
SEC61G -2328
SPCS1 -2007
RPL28 -1952
SPCS3 -1816
UBA52 -1437
FAU -1029
SSR3 -664
SRP19 -483
RPL39L -69
RPS4Y1 1461
SSR4 1961
RPS9 2392
RPS27L 2784
SEC61A1 3976
RPN1 4038
SEC61B 4523
SRP14 5005
SRPRA 5496
RPL3L 5700
RPL26L1 6187
SRP54 6468
RPN2 7108
SEC11A 7174
DDOST 7465


rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol
1352
set rRNA modification in the nucleus and cytosol
setSize 59
pANOVA 1.02e-13
s.dist -0.56
p.adjustANOVA 4.48e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
DKC1 -9835
NOP14 -9719
FBL -9671
RPS2 -9635
NOP58 -9366
NOL11 -9354
UTP4 -9338
NAT10 -9326
THUMPD1 -9311
DIMT1 -9230
WDR75 -9213
RPS6 -9170
BMS1 -9164
WDR43 -8851
NOP56 -8346
RPS14 -8337
UTP15 -8280
IMP4 -8233
RRP9 -8121
RPS7 -8047

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DKC1 -9835
NOP14 -9719
FBL -9671
RPS2 -9635
NOP58 -9366
NOL11 -9354
UTP4 -9338
NAT10 -9326
THUMPD1 -9311
DIMT1 -9230
WDR75 -9213
RPS6 -9170
BMS1 -9164
WDR43 -8851
NOP56 -8346
RPS14 -8337
UTP15 -8280
IMP4 -8233
RRP9 -8121
RPS7 -8047
SNU13 -7987
PDCD11 -7980
WDR3 -7973
DDX47 -7962
RCL1 -7761
PNO1 -7506
HEATR1 -7360
PWP2 -7199
IMP3 -6997
WDR46 -6977
NOL6 -6945
UTP20 -6898
EMG1 -6735
GAR1 -6696
MPHOSPH10 -6590
KRR1 -6432
NOP2 -6275
WDR36 -5853
DHX37 -5761
NHP2 -5747
UTP6 -5444
RRP7A -4574
DCAF13 -4245
UTP14A -3160
FCF1 -3010
UTP14C -1630
UTP3 -1460
TRMT112 -370
TSR3 -358
TBL3 55
RRP36 511
UTP11 1268
DDX52 1503
RPS9 2392
UTP18 3740
DDX49 4194
NOC4L 7461
NOP10 10793
SNORD3A 11429


Selenoamino acid metabolism

Selenoamino acid metabolism
1059
set Selenoamino acid metabolism
setSize 114
pANOVA 1.1e-24
s.dist -0.555
p.adjustANOVA 6.01e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
LARS1 -8879
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
IARS1 -8710
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
RPL4 -9065
RPL22 -8915
LARS1 -8879
RPS3 -8856
RPS25 -8832
RPL21 -8773
RPS27A -8722
IARS1 -8710
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
KARS1 -7645
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
RPS18 -7288
RPS8 -7161
RPS17 -7134
SEPSECS -7064
RPL19 -7006
RPL23 -6933
EPRS1 -6849
RPS29 -6791
DARS1 -6758
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
SARS1 -6425
RPL36 -6343
RPL8 -6274
SECISBP2 -6069
RPL27 -6068
RPL41 -6065
SCLY -5892
RPL39 -5790
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
RPS24 -5310
EEFSEC -5238
AIMP1 -5088
RPL37A -4774
RPSA -4559
RPL36AL -4148
RPLP1 -3887
PSTK -3075
QARS1 -3062
AHCY -2734
AIMP2 -2623
CTH -2211
RPL28 -1952
INMT -1946
UBA52 -1437
RARS1 -1110
FAU -1029
RPL39L -69
RPS4Y1 1461
EEF1E1 2209
RPS9 2392
RPS27L 2784
RPL3L 5700
RPL26L1 6187
SEPHS2 7242
GNMT 7343
HNMT 8194
TXNRD1 8216
PAPSS1 9661
MARS1 9700
GSR 10772
CBS 10976
PAPSS2 11736


rRNA processing

rRNA processing
1353
set rRNA processing
setSize 217
pANOVA 4.38e-44
s.dist -0.547
p.adjustANOVA 2.99e-41



Top enriched genes

Top 20 genes
GeneID Gene Rank
DKC1 -9835
TSR1 -9723
NOP14 -9719
RPL3 -9701
FBL -9671
RPS2 -9635
RPP40 -9619
MTERF4 -9490
RPL14 -9390
RPL23A -9382
GNL3 -9380
NOP58 -9366
RPL5 -9359
NOL11 -9354
UTP4 -9338
NAT10 -9326
THUMPD1 -9311
RPS3A -9257
NOB1 -9253
DIMT1 -9230

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DKC1 -9835
TSR1 -9723
NOP14 -9719
RPL3 -9701
FBL -9671
RPS2 -9635
RPP40 -9619
MTERF4 -9490
RPL14 -9390
RPL23A -9382
GNL3 -9380
NOP58 -9366
RPL5 -9359
NOL11 -9354
UTP4 -9338
NAT10 -9326
THUMPD1 -9311
RPS3A -9257
NOB1 -9253
DIMT1 -9230
WDR75 -9213
RPS6 -9170
NCL -9167
BMS1 -9164
RPL7 -9134
RPL4 -9065
RPL22 -8915
RPS3 -8856
WDR43 -8851
RPS25 -8832
RPL21 -8773
TEX10 -8744
RPS27A -8722
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
LAS1L -8501
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RIOK2 -8405
RPS12 -8401
NOP56 -8346
RPS14 -8337
RPS23 -8334
RPL10 -8318
UTP15 -8280
EXOSC5 -8271
TRMT10C -8270
RPS27 -8260
RPLP2 -8255
IMP4 -8233
EXOSC2 -8172
RPL36A -8130
NIP7 -8124
RRP9 -8121
RPS7 -8047
RPL35A -8046
RPL10A -7989
SNU13 -7987
EXOSC6 -7982
PDCD11 -7980
WDR3 -7973
DDX47 -7962
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
EXOSC8 -7905
RPL22L1 -7828
RPL30 -7783
RPL18 -7781
RCL1 -7761
RPL35 -7710
RPL26 -7648
RPS4X -7636
RPS10 -7629
RPL24 -7626
RPP25 -7624
RPS16 -7617
RPL18A -7609
CSNK1E -7527
RPL31 -7521
PNO1 -7506
EXOSC9 -7477
RPL9 -7451
RPL15 -7380
RPS13 -7375
HEATR1 -7360
PELP1 -7329
RPL7A -7296
RPS18 -7288
PWP2 -7199
NOL9 -7193
MRM1 -7180
RPP30 -7173
RPS8 -7161
RPS17 -7134
RPL19 -7006
IMP3 -6997
WDR46 -6977
NOL6 -6945
RPL23 -6933
UTP20 -6898
EBNA1BP2 -6864
RPS29 -6791
RPS11 -6742
EMG1 -6735
MT-ND2 -6727
RPS21 -6706
GAR1 -6696
RPL37 -6660
MPHOSPH10 -6590
RPL38 -6589
EXOSC7 -6585
RPP38 -6534
MT-RNR1 -6484
KRR1 -6432
RPS28 -6429
RPL36 -6343
NOP2 -6275
RPL8 -6274
RPL27 -6068
RPL41 -6065
BYSL -5863
WDR36 -5853
MT-ND1 -5852
RBM28 -5810
RPL39 -5790
DHX37 -5761
NHP2 -5747
RPS19 -5616
RPL13 -5550
RPS26 -5524
MRM3 -5496
PES1 -5491
UTP6 -5444
RPS15 -5342
RPS24 -5310
BOP1 -5141
EXOSC10 -5112
RPL37A -4774
MTREX -4734
TFB1M -4603
LTV1 -4592
RRP7A -4574
RPSA -4559
WDR18 -4348
MT-CO3 -4247
DCAF13 -4245
RPL36AL -4148
DIS3 -3916
RPLP1 -3887
DDX21 -3746
ELAC2 -3686
PRORP -3614
RIOK1 -3329
MRM2 -3190
MT-ND5 -3188
UTP14A -3160
FCF1 -3010
MT-ND3 -2969
RPP14 -2433
MPHOSPH6 -2335
MT-CYB -2095
RPL28 -1952
UTP14C -1630
UTP3 -1460
UBA52 -1437
WDR12 -1301
FAU -1029
TRMT112 -370
TSR3 -358
RPP21 -200
MT-RNR2 -141
RPL39L -69
ISG20L2 -43
MT-ATP6 36
TBL3 55
EXOSC3 280
MT-CO1 507
RRP36 511
C1D 531
MT-CO2 729
RRP1 874
MT-TF 1008
UTP11 1268
RPS4Y1 1461
DDX52 1503
MT-ATP8 1944
ERI1 1991
RPS9 2392
EXOSC1 2569
RIOK3 2755
RPS27L 2784
MT-ND4L 3155
FTSJ3 3515
UTP18 3740
NSUN4 4135
DDX49 4194
SENP3 4233
MT-TV 4515
MT-TL1 5025
RPL3L 5700
NOL12 5766
MT-ND4 5850
RPL26L1 6187
HSD17B10 6466
CSNK1D 7458
NOC4L 7461
EXOSC4 8895
XRN2 9350
NOP10 10793
SNORD3A 11429


Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
527
set Influenza Viral RNA Transcription and Replication
setSize 135
pANOVA 4.19e-28
s.dist -0.547
p.adjustANOVA 3.57e-26



Top enriched genes

Top 20 genes
GeneID Gene Rank
IPO5 -9839
NDC1 -9817
RPL3 -9701
RPS2 -9635
NUP35 -9626
NUP88 -9430
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
PARP1 -9133
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
NUP107 -8801
SEH1L -8792
RPL21 -8773

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IPO5 -9839
NDC1 -9817
RPL3 -9701
RPS2 -9635
NUP35 -9626
NUP88 -9430
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
PARP1 -9133
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
NUP107 -8801
SEH1L -8792
RPL21 -8773
RPS27A -8722
NUP160 -8699
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
POLR2D -8160
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
NUP43 -7792
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
NUP155 -7633
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
NUP188 -7295
RPS18 -7288
RPS8 -7161
RPS17 -7134
NUP205 -7051
RPL19 -7006
RPL23 -6933
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
POM121C -6074
RPL27 -6068
RPL41 -6065
RPL39 -5790
NUP133 -5674
RPS19 -5616
RPL13 -5550
RPS26 -5524
RPS15 -5342
NUP54 -5340
RPS24 -5310
POLR2B -5111
HSP90AA1 -5083
RPL37A -4774
RPSA -4559
NUP153 -4433
NUP210 -4373
RPL36AL -4148
TPR -4127
POLR2K -3902
RPLP1 -3887
POLR2H -3611
NUP93 -3163
GRSF1 -3125
RANBP2 -3109
NUP42 -2718
POLR2C -2566
POM121 -2295
RPL28 -1952
NUP85 -1717
POLR2I -1599
UBA52 -1437
NUP37 -1424
NUP50 -1242
FAU -1029
RPL39L -69
NUP98 175
NUP62 395
AAAS 627
RPS4Y1 1461
RPS9 2392
RPS27L 2784
POLR2L 3450
RAE1 5040
POLR2E 5238
GTF2F2 5263
GTF2F1 5494
POLR2G 5695
RPL3L 5700
POLR2F 5738
RPL26L1 6187
POLR2A 6387
SEC13 6793
NUP58 7628
POLR2J 7983
DNAJC3 8291
NUP214 10124


NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
706
set NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize 10
pANOVA 0.00284
s.dist 0.545
p.adjustANOVA 0.0173



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCSTN 11715
NOTCH4 11483
PSEN1 10871
PSENEN 9844
APH1B 9199
ADAM10 9130
JAG1 7859
APH1A 2205
YWHAZ -647
PSEN2 -3426

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCSTN 11715
NOTCH4 11483
PSEN1 10871
PSENEN 9844
APH1B 9199
ADAM10 9130
JAG1 7859
APH1A 2205
YWHAZ -647
PSEN2 -3426


Translation initiation complex formation

Translation initiation complex formation
1269
set Translation initiation complex formation
setSize 58
pANOVA 6.84e-13
s.dist -0.545
p.adjustANOVA 2.91e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS2 -9635
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS2 -9635
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766
RPS4X -7636
RPS10 -7629
RPS16 -7617
RPS13 -7375
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPS28 -6429
EIF3J -6001
EIF3H -5894
EIF3M -5620
RPS19 -5616
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPSA -4559
EIF3D -4337
EIF3C -3750
EIF3F -3748
PABPC1 -3482
EIF2S1 -3350
EIF3I -2671
EIF3G -1676
EIF3A -1537
FAU -1029
EIF3K -298
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF4E 2104
RPS9 2392
RPS27L 2784
EIF4A1 5928
EIF4H 7435
EIF4G1 9922


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1015
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 1.1e-12
s.dist -0.54
p.adjustANOVA 4.39e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS2 -9635
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS2 -9635
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766
RPS4X -7636
RPS10 -7629
RPS16 -7617
RPS13 -7375
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPS28 -6429
EIF3J -6001
EIF3H -5894
EIF3M -5620
RPS19 -5616
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPSA -4559
EIF3D -4337
EIF3C -3750
EIF3F -3748
EIF2S1 -3350
EIF3I -2671
EIF3G -1676
EIF3A -1537
FAU -1029
EIF5 -416
EIF3K -298
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF4E 2104
RPS9 2392
RPS27L 2784
EIF4A1 5928
EIF4H 7435
EIF4G1 9922


DNA strand elongation

DNA strand elongation
245
set DNA strand elongation
setSize 32
pANOVA 1.35e-07
s.dist -0.538
p.adjustANOVA 3.4e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -9769
POLD2 -9742
POLA1 -9660
RPA1 -9657
MCM6 -9297
RFC3 -8694
LIG1 -8618
PRIM1 -8268
GINS4 -8200
RPA3 -8069
RFC4 -7736
MCM7 -7720
MCM4 -7627
MCM2 -7557
FEN1 -7122
PCNA -6841
POLA2 -6222
MCM8 -6138
PRIM2 -5653
CDC45 -5643

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -9769
POLD2 -9742
POLA1 -9660
RPA1 -9657
MCM6 -9297
RFC3 -8694
LIG1 -8618
PRIM1 -8268
GINS4 -8200
RPA3 -8069
RFC4 -7736
MCM7 -7720
MCM4 -7627
MCM2 -7557
FEN1 -7122
PCNA -6841
POLA2 -6222
MCM8 -6138
PRIM2 -5653
CDC45 -5643
RFC1 -5493
RPA2 -4620
DNA2 -4017
GINS3 -3998
RFC5 -3986
GINS2 -3279
GINS1 -976
POLD1 646
MCM5 1277
RFC2 4835
POLD4 10344
POLD3 11274


Hyaluronan uptake and degradation

Hyaluronan uptake and degradation
504
set Hyaluronan uptake and degradation
setSize 12
pANOVA 0.00132
s.dist 0.535
p.adjustANOVA 0.00929



Top enriched genes

Top 20 genes
GeneID Gene Rank
HYAL2 11702
SLC9A1 11489
GUSB 11435
LYVE1 10683
CHP1 9397
HYAL1 8617
CD44 8470
HEXB 6925
STAB2 5526
HYAL3 304
HEXA -442
HMMR -3479

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HYAL2 11702
SLC9A1 11489
GUSB 11435
LYVE1 10683
CHP1 9397
HYAL1 8617
CD44 8470
HEXB 6925
STAB2 5526
HYAL3 304
HEXA -442
HMMR -3479


Heme degradation

Heme degradation
494
set Heme degradation
setSize 10
pANOVA 0.00364
s.dist 0.531
p.adjustANOVA 0.0212



Top enriched genes

Top 20 genes
GeneID Gene Rank
HMOX1 11521
GUSB 11435
BLVRA 10731
SLCO2B1 10574
ALB 9450
BLVRB 8156
ABCC1 7821
ABCC2 5072
ABCG2 1182
HMOX2 -9212

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HMOX1 11521
GUSB 11435
BLVRA 10731
SLCO2B1 10574
ALB 9450
BLVRB 8156
ABCC1 7821
ABCC2 5072
ABCG2 1182
HMOX2 -9212


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
49
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 2.07e-12
s.dist -0.529
p.adjustANOVA 8.07e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS2 -9635
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS2 -9635
EIF4A2 -9355
RPS3A -9257
RPS6 -9170
EIF3B -8874
RPS3 -8856
RPS25 -8832
RPS27A -8722
RPS5 -8698
EIF3E -8600
RPS20 -8476
RPS12 -8401
EIF1AX -8394
RPS14 -8337
RPS23 -8334
EIF4B -8328
RPS27 -8260
RPS7 -8047
RPS15A -7912
EIF3L -7766
RPS4X -7636
RPS10 -7629
RPS16 -7617
RPS13 -7375
RPS18 -7288
RPS8 -7161
RPS17 -7134
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPS28 -6429
EIF3J -6001
EIF3H -5894
EIF3M -5620
RPS19 -5616
RPS26 -5524
RPS15 -5342
RPS24 -5310
RPSA -4559
EIF3D -4337
EIF3C -3750
EIF3F -3748
PABPC1 -3482
EIF2S1 -3350
EIF3I -2671
EIF3G -1676
EIF3A -1537
FAU -1029
EIF3K -298
EIF2S2 297
EIF2S3 1308
RPS4Y1 1461
EIF4E 2104
RPS9 2392
RPS27L 2784
EIF4EBP1 5335
EIF4A1 5928
EIF4H 7435
EIF4G1 9922


PD-1 signaling

PD-1 signaling
778
set PD-1 signaling
setSize 28
pANOVA 1.37e-06
s.dist -0.527
p.adjustANOVA 2.92e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
CD3G -9125
HLA-DQB2 -9021
CD3D -8747
TRBC1 -8666
TRAV29DV5 -8326
PDCD1 -7990
TRAV8-4 -7607
CD274 -7428
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
HLA-DPA1 -5854
CD4 -4882

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
CD3G -9125
HLA-DQB2 -9021
CD3D -8747
TRBC1 -8666
TRAV29DV5 -8326
PDCD1 -7990
TRAV8-4 -7607
CD274 -7428
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
HLA-DPA1 -5854
CD4 -4882
HLA-DQA1 -1465
HLA-DRB5 -1119
HLA-DRB1 1353
PTPN11 2859
HLA-DQB1 3660
PDCD1LG2 4134
CSK 10310
PTPN6 11254


VLDLR internalisation and degradation

VLDLR internalisation and degradation
1310
set VLDLR internalisation and degradation
setSize 12
pANOVA 0.00178
s.dist 0.521
p.adjustANOVA 0.0116



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2A1 11707
PCSK9 11538
AP2A2 10434
AP2S1 9504
NR1H2 9385
CLTC 9346
CLTA 7680
VLDLR 7597
AP2M1 7323
NR1H3 5458
AP2B1 -3690
MYLIP -7517

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2A1 11707
PCSK9 11538
AP2A2 10434
AP2S1 9504
NR1H2 9385
CLTC 9346
CLTA 7680
VLDLR 7597
AP2M1 7323
NR1H3 5458
AP2B1 -3690
MYLIP -7517


Telomere C-strand synthesis initiation

Telomere C-strand synthesis initiation
1220
set Telomere C-strand synthesis initiation
setSize 13
pANOVA 0.00136
s.dist -0.513
p.adjustANOVA 0.00936



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLA1 -9660
STN1 -9499
PRIM1 -8268
CTC1 -8006
POLA2 -6222
POT1 -5841
PRIM2 -5653
TERF2 -4926
ACD -3963
TERF1 -3813
TERF2IP -1108
TEN1 1027
TINF2 5948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLA1 -9660
STN1 -9499
PRIM1 -8268
CTC1 -8006
POLA2 -6222
POT1 -5841
PRIM2 -5653
TERF2 -4926
ACD -3963
TERF1 -3813
TERF2IP -1108
TEN1 1027
TINF2 5948


Nucleobase biosynthesis

Nucleobase biosynthesis
754
set Nucleobase biosynthesis
setSize 13
pANOVA 0.00145
s.dist -0.51
p.adjustANOVA 0.00989



Top enriched genes

Top 20 genes
GeneID Gene Rank
IMPDH2 -9848
ATIC -9759
PPAT -9694
UMPS -9690
PAICS -9126
PFAS -8632
CAD -8324
GMPS -6586
ADSL -3203
DHODH -2273
LHPP 423
GART 5826
IMPDH1 11335

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IMPDH2 -9848
ATIC -9759
PPAT -9694
UMPS -9690
PAICS -9126
PFAS -8632
CAD -8324
GMPS -6586
ADSL -3203
DHODH -2273
LHPP 423
GART 5826
IMPDH1 11335


MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
619
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.00525
s.dist 0.51
p.adjustANOVA 0.0286



Top enriched genes

Top 20 genes
GeneID Gene Rank
GRB2 10925
RAC1 10907
HGF 10314
GAB1 9727
CRK 9373
RAP1A 7021
RAP1B 5363
RAPGEF1 3848
CRKL -238
DOCK7 -2815

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GRB2 10925
RAC1 10907
HGF 10314
GAB1 9727
CRK 9373
RAP1A 7021
RAP1B 5363
RAPGEF1 3848
CRKL -238
DOCK7 -2815


Influenza Infection

Influenza Infection
526
set Influenza Infection
setSize 154
pANOVA 5.85e-27
s.dist -0.501
p.adjustANOVA 3.8e-25



Top enriched genes

Top 20 genes
GeneID Gene Rank
IPO5 -9839
NDC1 -9817
RPL3 -9701
RPS2 -9635
NUP35 -9626
NUP88 -9430
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
PARP1 -9133
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
NUP107 -8801
SEH1L -8792
RPL21 -8773

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IPO5 -9839
NDC1 -9817
RPL3 -9701
RPS2 -9635
NUP35 -9626
NUP88 -9430
RPL14 -9390
RPL23A -9382
RPL5 -9359
RPS3A -9257
RPS6 -9170
RPL7 -9134
PARP1 -9133
RPL4 -9065
RPL22 -8915
RPS3 -8856
RPS25 -8832
NUP107 -8801
SEH1L -8792
RPL21 -8773
RPS27A -8722
NUP160 -8699
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
RPS14 -8337
RPS23 -8334
RPL10 -8318
RPS27 -8260
RPLP2 -8255
POLR2D -8160
RPL36A -8130
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
RPL11 -7928
RPL32 -7914
RPS15A -7912
RPL22L1 -7828
NUP43 -7792
RPL30 -7783
RPL18 -7781
RPL35 -7710
RPL26 -7648
RPS4X -7636
NUP155 -7633
RPS10 -7629
RPL24 -7626
RPS16 -7617
RPL18A -7609
RAN -7577
KPNA5 -7556
RPL31 -7521
RPL9 -7451
RPL15 -7380
RPS13 -7375
RPL7A -7296
NUP188 -7295
RPS18 -7288
RPS8 -7161
RPS17 -7134
NUP205 -7051
RPL19 -7006
RPL23 -6933
ISG15 -6814
RPS29 -6791
RPS11 -6742
RPS21 -6706
RPL37 -6660
RPL38 -6589
RPS28 -6429
RPL36 -6343
RPL8 -6274
POM121C -6074
RPL27 -6068
RPL41 -6065
RPL39 -5790
NUP133 -5674
RPS19 -5616
SLC25A6 -5581
RPL13 -5550
RPS26 -5524
RPS15 -5342
NUP54 -5340
RPS24 -5310
POLR2B -5111
HSP90AA1 -5083
RPL37A -4774
RPSA -4559
NUP153 -4433
NUP210 -4373
KPNA1 -4278
KPNA3 -4263
XPO1 -4204
RPL36AL -4148
TPR -4127
POLR2K -3902
RPLP1 -3887
KPNA2 -3851
POLR2H -3611
NUP93 -3163
GRSF1 -3125
RANBP2 -3109
NUP42 -2718
POLR2C -2566
CPSF4 -2319
POM121 -2295
RPL28 -1952
NUP85 -1717
POLR2I -1599
UBA52 -1437
NUP37 -1424
CANX -1278
NUP50 -1242
FAU -1029
KPNA4 -701
TGFB1 -615
KPNB1 -109
RPL39L -69
NUP98 175
NUP62 395
EIF2AK2 426
AAAS 627
RPS4Y1 1461
RPS9 2392
PABPN1 2573
RPS27L 2784
POLR2L 3450
CALR 4966
RAE1 5040
POLR2E 5238
GTF2F2 5263
GTF2F1 5494
POLR2G 5695
RPL3L 5700
POLR2F 5738
RPL26L1 6187
POLR2A 6387
HSPA1A 6708
SEC13 6793
NUP58 7628
CLTA 7680
POLR2J 7983
DNAJC3 8291
CLTC 9346
NUP214 10124


Processive synthesis on the lagging strand

Processive synthesis on the lagging strand
859
set Processive synthesis on the lagging strand
setSize 15
pANOVA 0.000907
s.dist -0.495
p.adjustANOVA 0.00711



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
LIG1 -8618
PRIM1 -8268
RPA3 -8069
FEN1 -7122
PCNA -6841
POLA2 -6222
PRIM2 -5653
RPA2 -4620
DNA2 -4017
POLD1 646
POLD4 10344
POLD3 11274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
LIG1 -8618
PRIM1 -8268
RPA3 -8069
FEN1 -7122
PCNA -6841
POLA2 -6222
PRIM2 -5653
RPA2 -4620
DNA2 -4017
POLD1 646
POLD4 10344
POLD3 11274


Activation of ATR in response to replication stress

Activation of ATR in response to replication stress
33
set Activation of ATR in response to replication stress
setSize 37
pANOVA 1.91e-07
s.dist -0.495
p.adjustANOVA 4.72e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
MCM3 -9769
RPA1 -9657
RAD1 -9471
MCM6 -9297
RFC3 -8694
DBF4 -8484
ORC2 -8097
ORC5 -8089
RPA3 -8069
RAD17 -7742
RFC4 -7736
MCM7 -7720
MCM4 -7627
ORC3 -7568
MCM2 -7557
MCM10 -6777
MCM8 -6138
CHEK1 -6036
ORC4 -5692
CDC45 -5643

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MCM3 -9769
RPA1 -9657
RAD1 -9471
MCM6 -9297
RFC3 -8694
DBF4 -8484
ORC2 -8097
ORC5 -8089
RPA3 -8069
RAD17 -7742
RFC4 -7736
MCM7 -7720
MCM4 -7627
ORC3 -7568
MCM2 -7557
MCM10 -6777
MCM8 -6138
CHEK1 -6036
ORC4 -5692
CDC45 -5643
CDC6 -5479
ORC1 -5158
RAD9A -5073
RPA2 -4620
RFC5 -3986
CDK2 -3694
ATR -2784
CDC25A -2547
ATRIP -1520
CLSPN -178
CDC7 815
MCM5 1277
CDC25C 1278
HUS1 2327
RFC2 4835
ORC6 8542
RAD9B 8706


Lagging Strand Synthesis

Lagging Strand Synthesis
591
set Lagging Strand Synthesis
setSize 20
pANOVA 0.000147
s.dist -0.49
p.adjustANOVA 0.00167



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
RFC3 -8694
LIG1 -8618
PRIM1 -8268
RPA3 -8069
RFC4 -7736
FEN1 -7122
PCNA -6841
POLA2 -6222
PRIM2 -5653
RFC1 -5493
RPA2 -4620
DNA2 -4017
RFC5 -3986
POLD1 646
RFC2 4835
POLD4 10344
POLD3 11274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
RFC3 -8694
LIG1 -8618
PRIM1 -8268
RPA3 -8069
RFC4 -7736
FEN1 -7122
PCNA -6841
POLA2 -6222
PRIM2 -5653
RFC1 -5493
RPA2 -4620
DNA2 -4017
RFC5 -3986
POLD1 646
RFC2 4835
POLD4 10344
POLD3 11274


Telomere C-strand (Lagging Strand) Synthesis

Telomere C-strand (Lagging Strand) Synthesis
1219
set Telomere C-strand (Lagging Strand) Synthesis
setSize 34
pANOVA 7.85e-07
s.dist -0.489
p.adjustANOVA 1.81e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
STN1 -9499
WRN -9097
CHTF18 -8785
RFC3 -8694
LIG1 -8618
PRIM1 -8268
RPA3 -8069
CTC1 -8006
RFC4 -7736
DSCC1 -7671
FEN1 -7122
PCNA -6841
POLA2 -6222
POT1 -5841
PRIM2 -5653
RFC1 -5493
TERF2 -4926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
STN1 -9499
WRN -9097
CHTF18 -8785
RFC3 -8694
LIG1 -8618
PRIM1 -8268
RPA3 -8069
CTC1 -8006
RFC4 -7736
DSCC1 -7671
FEN1 -7122
PCNA -6841
POLA2 -6222
POT1 -5841
PRIM2 -5653
RFC1 -5493
TERF2 -4926
RPA2 -4620
BLM -4432
DNA2 -4017
RFC5 -3986
ACD -3963
TERF1 -3813
TERF2IP -1108
CHTF8 -503
POLD1 646
TEN1 1027
RFC2 4835
TINF2 5948
POLD4 10344
POLD3 11274


RHO GTPases Activate ROCKs

RHO GTPases Activate ROCKs
887
set RHO GTPases Activate ROCKs
setSize 18
pANOVA 0.000359
s.dist 0.486
p.adjustANOVA 0.00318



Top enriched genes

Top 20 genes
GeneID Gene Rank
PAK1 10704
MYL6 10033
CFL1 9683
LIMK1 9261
RHOC 8798
RHOA 8752
LIMK2 8172
MYH10 7202
PPP1R12B 7089
ROCK1 7020
MYH9 6290
RHOB 5919
ROCK2 5519
MYL12B 4733
PPP1R12A 4439
PPP1CB 2847
MYH11 -619
MYL9 -4572

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PAK1 10704
MYL6 10033
CFL1 9683
LIMK1 9261
RHOC 8798
RHOA 8752
LIMK2 8172
MYH10 7202
PPP1R12B 7089
ROCK1 7020
MYH9 6290
RHOB 5919
ROCK2 5519
MYL12B 4733
PPP1R12A 4439
PPP1CB 2847
MYH11 -619
MYL9 -4572


Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
820
set Phosphorylation of CD3 and TCR zeta chains
setSize 27
pANOVA 1.96e-05
s.dist -0.475
p.adjustANOVA 0.000296



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
CD3G -9125
HLA-DQB2 -9021
CD3D -8747
TRBC1 -8666
TRAV29DV5 -8326
TRAV8-4 -7607
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
HLA-DPA1 -5854
CD4 -4882
HLA-DQA1 -1465
HLA-DRB5 -1119

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
CD3G -9125
HLA-DQB2 -9021
CD3D -8747
TRBC1 -8666
TRAV29DV5 -8326
TRAV8-4 -7607
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
HLA-DPA1 -5854
CD4 -4882
HLA-DQA1 -1465
HLA-DRB5 -1119
PAG1 322
HLA-DRB1 1353
HLA-DQB1 3660
PTPN22 5604
PTPRC 7546
PTPRJ 9428
CSK 10310


Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway
998
set Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize 24
pANOVA 6.05e-05
s.dist -0.473
p.adjustANOVA 0.000809



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
APEX1 -9705
RPA1 -9657
PARP1 -9133
POLE3 -8924
RFC3 -8694
LIG1 -8618
RPA3 -8069
RFC4 -7736
FEN1 -7122
PCNA -6841
POLE2 -6659
RFC1 -5493
PARP2 -5385
RPA2 -4620
POLB -4374
RFC5 -3986
POLE -1479
POLE4 -1186
PARG 84

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
APEX1 -9705
RPA1 -9657
PARP1 -9133
POLE3 -8924
RFC3 -8694
LIG1 -8618
RPA3 -8069
RFC4 -7736
FEN1 -7122
PCNA -6841
POLE2 -6659
RFC1 -5493
PARP2 -5385
RPA2 -4620
POLB -4374
RFC5 -3986
POLE -1479
POLE4 -1186
PARG 84
POLD1 646
RFC2 4835
POLD4 10344
POLD3 11274


Removal of the Flap Intermediate

Removal of the Flap Intermediate
994
set Removal of the Flap Intermediate
setSize 14
pANOVA 0.00248
s.dist -0.467
p.adjustANOVA 0.0157



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
PRIM1 -8268
RPA3 -8069
FEN1 -7122
PCNA -6841
POLA2 -6222
PRIM2 -5653
RPA2 -4620
DNA2 -4017
POLD1 646
POLD4 10344
POLD3 11274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RPA1 -9657
PRIM1 -8268
RPA3 -8069
FEN1 -7122
PCNA -6841
POLA2 -6222
PRIM2 -5653
RPA2 -4620
DNA2 -4017
POLD1 646
POLD4 10344
POLD3 11274


PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair
776
set PCNA-Dependent Long Patch Base Excision Repair
setSize 21
pANOVA 0.000229
s.dist -0.464
p.adjustANOVA 0.00229



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
APEX1 -9705
RPA1 -9657
POLE3 -8924
RFC3 -8694
LIG1 -8618
RPA3 -8069
RFC4 -7736
FEN1 -7122
PCNA -6841
POLE2 -6659
RFC1 -5493
RPA2 -4620
POLB -4374
RFC5 -3986
POLE -1479
POLE4 -1186
POLD1 646
RFC2 4835
POLD4 10344

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
APEX1 -9705
RPA1 -9657
POLE3 -8924
RFC3 -8694
LIG1 -8618
RPA3 -8069
RFC4 -7736
FEN1 -7122
PCNA -6841
POLE2 -6659
RFC1 -5493
RPA2 -4620
POLB -4374
RFC5 -3986
POLE -1479
POLE4 -1186
POLD1 646
RFC2 4835
POLD4 10344
POLD3 11274


BBSome-mediated cargo-targeting to cilium

BBSome-mediated cargo-targeting to cilium
98
set BBSome-mediated cargo-targeting to cilium
setSize 22
pANOVA 0.00019
s.dist -0.46
p.adjustANOVA 0.00202



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCT2 -9661
BBS9 -7939
LZTFL1 -7906
CCT4 -7510
SSTR3 -7486
MKKS -7400
BBS5 -6824
BBS2 -6808
CCT3 -6559
BBS1 -5958
TCP1 -5286
ARL6 -4721
BBS10 -3126
BBIP1 -2982
MCHR1 -1970
BBS12 -1918
RAB3IP -1300
BBS4 -418
CCT8 -260
BBS7 1167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCT2 -9661
BBS9 -7939
LZTFL1 -7906
CCT4 -7510
SSTR3 -7486
MKKS -7400
BBS5 -6824
BBS2 -6808
CCT3 -6559
BBS1 -5958
TCP1 -5286
ARL6 -4721
BBS10 -3126
BBIP1 -2982
MCHR1 -1970
BBS12 -1918
RAB3IP -1300
BBS4 -418
CCT8 -260
BBS7 1167
CCT5 2169
TTC8 3955


Generation of second messenger molecules

Generation of second messenger molecules
444
set Generation of second messenger molecules
setSize 38
pANOVA 1.37e-06
s.dist -0.453
p.adjustANOVA 2.92e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
ITK -9231
LAT -9159
CD3G -9125
HLA-DQB2 -9021
NCK1 -8821
CD3D -8747
TRBC1 -8666
ZAP70 -8662
EVL -8581
PLCG1 -8497
TRAV29DV5 -8326
TRAV8-4 -7607
HLA-DPB1 -7109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TRBV12-3 -9724
CD247 -9497
LCK -9485
HLA-DQA2 -9407
TRAV19 -9396
CD3E -9378
TRAC -9330
ITK -9231
LAT -9159
CD3G -9125
HLA-DQB2 -9021
NCK1 -8821
CD3D -8747
TRBC1 -8666
ZAP70 -8662
EVL -8581
PLCG1 -8497
TRAV29DV5 -8326
TRAV8-4 -7607
HLA-DPB1 -7109
TRBV7-9 -6741
HLA-DRA -6613
GRAP2 -6236
HLA-DPA1 -5854
CD4 -4882
HLA-DQA1 -1465
HLA-DRB5 -1119
PAK3 -533
LCP2 514
CD101 551
HLA-DRB1 1353
HLA-DQB1 3660
PAK2 5789
ENAH 6964
VASP 9774
PLCG2 10376
PAK1 10704
WAS 11238


Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling
60
set Advanced glycosylation endproduct receptor signaling
setSize 12
pANOVA 0.00676
s.dist 0.451
p.adjustANOVA 0.0351



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100A12 11077
MAPK1 10847
MAPK3 9636
LGALS3 9294
CAPZA1 8032
CAPZA2 7999
AGER 7730
DDOST 7465
PRKCSH 5698
APP 3315
S100B -3661
HMGB1 -7684

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100A12 11077
MAPK1 10847
MAPK3 9636
LGALS3 9294
CAPZA1 8032
CAPZA2 7999
AGER 7730
DDOST 7465
PRKCSH 5698
APP 3315
S100B -3661
HMGB1 -7684


Gap junction trafficking

Gap junction trafficking
436
set Gap junction trafficking
setSize 13
pANOVA 0.00493
s.dist 0.45
p.adjustANOVA 0.0271



Top enriched genes

Top 20 genes
GeneID Gene Rank
DAB2 10889
GJD3 10882
DNM2 9736
CLTC 9346
CLTCL1 9020
CLTB 8275
CLTA 7680
AP2M1 7323
GJC1 5867
DNM1 5834
GJC2 2387
GJB6 -4155
MYO6 -7690

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DAB2 10889
GJD3 10882
DNM2 9736
CLTC 9346
CLTCL1 9020
CLTB 8275
CLTA 7680
AP2M1 7323
GJC1 5867
DNM1 5834
GJC2 2387
GJB6 -4155
MYO6 -7690


Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis
870
set Purine ribonucleoside monophosphate biosynthesis
setSize 10
pANOVA 0.0139
s.dist -0.449
p.adjustANOVA 0.0599



Top enriched genes

Top 20 genes
GeneID Gene Rank
IMPDH2 -9848
ATIC -9759
PPAT -9694
PAICS -9126
PFAS -8632
GMPS -6586
ADSL -3203
LHPP 423
GART 5826
IMPDH1 11335

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IMPDH2 -9848
ATIC -9759
PPAT -9694
PAICS -9126
PFAS -8632
GMPS -6586
ADSL -3203
LHPP 423
GART 5826
IMPDH1 11335


Early Phase of HIV Life Cycle

Early Phase of HIV Life Cycle
333
set Early Phase of HIV Life Cycle
setSize 14
pANOVA 0.00392
s.dist -0.445
p.adjustANOVA 0.0225



Top enriched genes

Top 20 genes
GeneID Gene Rank
PSIP1 -8864
LIG1 -8618
HMGA1 -8468
XRCC6 -7770
FEN1 -7122
CCR5 -5824
CD4 -4882
PPIA -4561
BANF1 -4324
KPNA1 -4278
XRCC5 -2484
CXCR4 -2277
XRCC4 6153
LIG4 8990

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PSIP1 -8864
LIG1 -8618
HMGA1 -8468
XRCC6 -7770
FEN1 -7122
CCR5 -5824
CD4 -4882
PPIA -4561
BANF1 -4324
KPNA1 -4278
XRCC5 -2484
CXCR4 -2277
XRCC4 6153
LIG4 8990


SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1035
set SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize 11
pANOVA 0.0107
s.dist -0.445
p.adjustANOVA 0.0495



Top enriched genes

Top 20 genes
GeneID Gene Rank
LSM11 -9482
ZNF473 -8717
NCBP2 -8212
SNRPE -6979
SNRPF -6725
SLBP -4830
SNRPD3 -4404
SNRPB -3546
NCBP1 -1125
SNRPG 3835
LSM10 7576

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LSM11 -9482
ZNF473 -8717
NCBP2 -8212
SNRPE -6979
SNRPF -6725
SLBP -4830
SNRPD3 -4404
SNRPB -3546
NCBP1 -1125
SNRPG 3835
LSM10 7576


Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion
347
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 0.011
s.dist -0.443
p.adjustANOVA 0.0506



Top enriched genes

Top 20 genes
GeneID Gene Rank
STAG1 -6554
ESCO1 -6521
RAD21 -6258
SMC3 -5758
PDS5A -4597
CDCA5 -3870
STAG2 -2436
PDS5B -2230
ESCO2 -2104
WAPL -1381
SMC1A -662

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
STAG1 -6554
ESCO1 -6521
RAD21 -6258
SMC3 -5758
PDS5A -4597
CDCA5 -3870
STAG2 -2436
PDS5B -2230
ESCO2 -2104
WAPL -1381
SMC1A -662


Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)
1166
set Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize 15
pANOVA 0.00306
s.dist 0.442
p.adjustANOVA 0.0184



Top enriched genes

Top 20 genes
GeneID Gene Rank
GGT1 11721
CYP4F8 11319
PTGR1 11262
ALOX5 11153
LTA4H 11060
ABCC1 7821
ALOX5AP 7665
GGT5 6798
MAPKAPK2 6495
CYP4F22 3837
DPEP2 3646
CYP4F3 2865
DPEP3 74
LTC4S -942
ALOX15 -9193

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
GGT1 11721
CYP4F8 11319
PTGR1 11262
ALOX5 11153
LTA4H 11060
ABCC1 7821
ALOX5AP 7665
GGT5 6798
MAPKAPK2 6495
CYP4F22 3837
DPEP2 3646
CYP4F3 2865
DPEP3 74
LTC4S -942
ALOX15 -9193


Postmitotic nuclear pore complex (NPC) reformation

Postmitotic nuclear pore complex (NPC) reformation
842
set Postmitotic nuclear pore complex (NPC) reformation
setSize 27
pANOVA 7.16e-05
s.dist -0.441
p.adjustANOVA 0.00091



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP107 -8801
SEH1L -8792
NUP160 -8699
RANGAP1 -8224
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
NUP133 -5674
NUP54 -5340
AHCTF1 -5169
TNPO1 -3493
NUP93 -3163
RCC1 -3085
POM121 -2295
NUP85 -1717
NUP37 -1424

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP107 -8801
SEH1L -8792
NUP160 -8699
RANGAP1 -8224
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
NUP133 -5674
NUP54 -5340
AHCTF1 -5169
TNPO1 -3493
NUP93 -3163
RCC1 -3085
POM121 -2295
NUP85 -1717
NUP37 -1424
KPNB1 -109
NUP98 175
NUP62 395
UBE2I 587
SUMO1 3612
SEC13 6793
NUP58 7628


Interactions of Vpr with host cellular proteins

Interactions of Vpr with host cellular proteins
546
set Interactions of Vpr with host cellular proteins
setSize 37
pANOVA 3.55e-06
s.dist -0.44
p.adjustANOVA 6.81e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
PSIP1 -8864
NUP107 -8801
SEH1L -8792
NUP160 -8699
HMGA1 -8468
NUP43 -7792
NUP155 -7633
SLC25A4 -7576
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
SLC25A6 -5581
NUP54 -5340
NUP153 -4433
NUP210 -4373
BANF1 -4324

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
PSIP1 -8864
NUP107 -8801
SEH1L -8792
NUP160 -8699
HMGA1 -8468
NUP43 -7792
NUP155 -7633
SLC25A4 -7576
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
SLC25A6 -5581
NUP54 -5340
NUP153 -4433
NUP210 -4373
BANF1 -4324
KPNA1 -4278
TPR -4127
NUP93 -3163
RANBP2 -3109
NUP42 -2718
SLC25A5 -2499
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade
287
set Diseases associated with the TLR signaling cascade
setSize 23
pANOVA 0.000281
s.dist 0.437
p.adjustANOVA 0.00263



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
UNC93B1 11011
TLR5 10992
TLR2 10761
CD14 10542
LY96 10002
TICAM1 9637
TLR4 9355
IKBKG 8902
TLR1 8749
TLR6 7631
CHUK 7179
TIRAP 6862
IKBKB 5156
NFKBIA 3946
NFKB2 1272
NFKB1 -2166
RELA -2563

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
UNC93B1 11011
TLR5 10992
TLR2 10761
CD14 10542
LY96 10002
TICAM1 9637
TLR4 9355
IKBKG 8902
TLR1 8749
TLR6 7631
CHUK 7179
TIRAP 6862
IKBKB 5156
NFKBIA 3946
NFKB2 1272
NFKB1 -2166
RELA -2563
TRAF3 -5198
TLR10 -6794
TLR3 -9494


Diseases of Immune System

Diseases of Immune System
289
set Diseases of Immune System
setSize 23
pANOVA 0.000281
s.dist 0.437
p.adjustANOVA 0.00263



Top enriched genes

Top 20 genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
UNC93B1 11011
TLR5 10992
TLR2 10761
CD14 10542
LY96 10002
TICAM1 9637
TLR4 9355
IKBKG 8902
TLR1 8749
TLR6 7631
CHUK 7179
TIRAP 6862
IKBKB 5156
NFKBIA 3946
NFKB2 1272
NFKB1 -2166
RELA -2563

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MYD88 11614
BTK 11379
CD36 11354
UNC93B1 11011
TLR5 10992
TLR2 10761
CD14 10542
LY96 10002
TICAM1 9637
TLR4 9355
IKBKG 8902
TLR1 8749
TLR6 7631
CHUK 7179
TIRAP 6862
IKBKB 5156
NFKBIA 3946
NFKB2 1272
NFKB1 -2166
RELA -2563
TRAF3 -5198
TLR10 -6794
TLR3 -9494


CD22 mediated BCR regulation

CD22 mediated BCR regulation
121
set CD22 mediated BCR regulation
setSize 59
pANOVA 6.94e-09
s.dist -0.436
p.adjustANOVA 2.31e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9443
IGLV6-57 -8979
CD79A -8733
IGLV2-14 -8599
IGHV3-33 -8574
IGKV1-16 -8350
IGLV3-21 -8327
IGLV3-1 -8150
IGKV3-15 -7683
IGHV1-69 -7589
IGLV2-8 -7468
IGKV1-5 -7365
IGLV3-19 -7358
IGKV4-1 -7302
CD79B -7082
CD22 -6705
IGHV3-53 -6692
IGHV4-34 -6614
IGHV2-5 -6583
IGHV3-48 -5881

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9443
IGLV6-57 -8979
CD79A -8733
IGLV2-14 -8599
IGHV3-33 -8574
IGKV1-16 -8350
IGLV3-21 -8327
IGLV3-1 -8150
IGKV3-15 -7683
IGHV1-69 -7589
IGLV2-8 -7468
IGKV1-5 -7365
IGLV3-19 -7358
IGKV4-1 -7302
CD79B -7082
CD22 -6705
IGHV3-53 -6692
IGHV4-34 -6614
IGHV2-5 -6583
IGHV3-48 -5881
IGLC7 -5764
IGLV3-27 -5637
IGHV3-23 -5636
IGHV1-2 -5526
IGLV1-51 -5296
IGKC -5232
IGHV3-7 -5228
IGHD -5224
IGHM -5149
IGLC2 -5138
IGKV3-20 -5082
IGKV1-33 -4953
IGHV4-39 -4884
IGHV3-30 -4685
IGLV1-47 -4485
IGKV1-12 -4392
IGKV2-28 -4281
IGLC1 -4280
IGHV2-70 -4223
IGHV3-11 -3626
IGHV1-46 -3558
IGLV1-40 -3024
IGKV2-30 -2958
IGKV1-17 -2929
IGHV4-59 -2340
IGLV3-25 -1935
IGHV3-13 -1600
IGLV1-44 -1090
IGKV2D-28 -728
IGLC3 -403
IGKV3D-20 -305
IGLV2-23 1244
IGKV5-2 3051
IGLV2-11 3601
IGKV1D-39 3771
IGLV7-43 7123
IGKV1-39 9771
LYN 10893
PTPN6 11254


SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs
1036
set SLBP independent Processing of Histone Pre-mRNAs
setSize 10
pANOVA 0.017
s.dist -0.436
p.adjustANOVA 0.0704



Top enriched genes

Top 20 genes
GeneID Gene Rank
LSM11 -9482
ZNF473 -8717
NCBP2 -8212
SNRPE -6979
SNRPF -6725
SNRPD3 -4404
SNRPB -3546
NCBP1 -1125
SNRPG 3835
LSM10 7576

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LSM11 -9482
ZNF473 -8717
NCBP2 -8212
SNRPE -6979
SNRPF -6725
SNRPD3 -4404
SNRPB -3546
NCBP1 -1125
SNRPG 3835
LSM10 7576


Translesion synthesis by REV1

Translesion synthesis by REV1
1275
set Translesion synthesis by REV1
setSize 16
pANOVA 0.00258
s.dist -0.435
p.adjustANOVA 0.0161



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA1 -9657
RPS27A -8722
RFC3 -8694
RPA3 -8069
RFC4 -7736
REV1 -7246
PCNA -6841
RFC1 -5493
RPA2 -4620
REV3L -4275
RFC5 -3986
UBB -2442
UBA52 -1437
RFC2 4835
UBC 4874
MAD2L2 9187

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA1 -9657
RPS27A -8722
RFC3 -8694
RPA3 -8069
RFC4 -7736
REV1 -7246
PCNA -6841
RFC1 -5493
RPA2 -4620
REV3L -4275
RFC5 -3986
UBB -2442
UBA52 -1437
RFC2 4835
UBC 4874
MAD2L2 9187


Interactions of Rev with host cellular proteins

Interactions of Rev with host cellular proteins
545
set Interactions of Rev with host cellular proteins
setSize 37
pANOVA 4.77e-06
s.dist -0.435
p.adjustANOVA 8.66e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
NPM1 -9836
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
RANGAP1 -8224
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
RANBP1 -6221
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
XPO1 -4204

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NPM1 -9836
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
RANGAP1 -8224
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
RANBP1 -6221
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
XPO1 -4204
TPR -4127
NUP93 -3163
RANBP2 -3109
RCC1 -3085
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
KPNB1 -109
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
300
set Dissolution of Fibrin Clot
setSize 12
pANOVA 0.0097
s.dist 0.431
p.adjustANOVA 0.0464



Top enriched genes

Top 20 genes
GeneID Gene Rank
ANXA2 11174
PLAUR 10834
SERPINB2 10828
SERPINB6 9209
SERPINB8 7711
S100A10 6864
SERPINE2 5551
SERPINF2 3535
PLAU 2369
PLG 1297
SERPINE1 -1083
PLAT -1179

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ANXA2 11174
PLAUR 10834
SERPINB2 10828
SERPINB6 9209
SERPINB8 7711
S100A10 6864
SERPINE2 5551
SERPINF2 3535
PLAU 2369
PLG 1297
SERPINE1 -1083
PLAT -1179


Extension of Telomeres

Extension of Telomeres
354
set Extension of Telomeres
setSize 51
pANOVA 1.09e-07
s.dist -0.43
p.adjustANOVA 2.87e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
DKC1 -9835
POLD2 -9742
POLA1 -9660
RPA1 -9657
STN1 -9499
WRN -9097
CHTF18 -8785
RFC3 -8694
LIG1 -8618
PRIM1 -8268
RPA3 -8069
CTC1 -8006
SHQ1 -7860
RUVBL1 -7856
RFC4 -7736
DSCC1 -7671
FEN1 -7122
PCNA -6841
GAR1 -6696
POLA2 -6222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DKC1 -9835
POLD2 -9742
POLA1 -9660
RPA1 -9657
STN1 -9499
WRN -9097
CHTF18 -8785
RFC3 -8694
LIG1 -8618
PRIM1 -8268
RPA3 -8069
CTC1 -8006
SHQ1 -7860
RUVBL1 -7856
RFC4 -7736
DSCC1 -7671
FEN1 -7122
PCNA -6841
GAR1 -6696
POLA2 -6222
TERT -6124
POT1 -5841
ANKRD28 -5772
NHP2 -5747
PRIM2 -5653
RFC1 -5493
TERF2 -4926
RPA2 -4620
BLM -4432
WRAP53 -4086
DNA2 -4017
RFC5 -3986
ACD -3963
TERF1 -3813
CDK2 -3694
CCNA1 -2231
CCNA2 -1727
PPP6C -1168
TERF2IP -1108
CHTF8 -503
PPP6R3 -249
POLD1 646
TEN1 1027
PIF1 1616
RUVBL2 2364
RFC2 4835
TINF2 5948
RTEL1 7274
POLD4 10344
NOP10 10793
POLD3 11274


Vpr-mediated nuclear import of PICs

Vpr-mediated nuclear import of PICs
1319
set Vpr-mediated nuclear import of PICs
setSize 34
pANOVA 1.5e-05
s.dist -0.429
p.adjustANOVA 0.000232



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
PSIP1 -8864
NUP107 -8801
SEH1L -8792
NUP160 -8699
HMGA1 -8468
NUP43 -7792
NUP155 -7633
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
BANF1 -4324
KPNA1 -4278
TPR -4127

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
PSIP1 -8864
NUP107 -8801
SEH1L -8792
NUP160 -8699
HMGA1 -8468
NUP43 -7792
NUP155 -7633
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
BANF1 -4324
KPNA1 -4278
TPR -4127
NUP93 -3163
RANBP2 -3109
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Rev-mediated nuclear export of HIV RNA

Rev-mediated nuclear export of HIV RNA
1013
set Rev-mediated nuclear export of HIV RNA
setSize 35
pANOVA 1.17e-05
s.dist -0.428
p.adjustANOVA 0.000193



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
RANGAP1 -8224
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
RANBP1 -6221
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
XPO1 -4204
TPR -4127

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
RANGAP1 -8224
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
RANBP1 -6221
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
XPO1 -4204
TPR -4127
NUP93 -3163
RANBP2 -3109
RCC1 -3085
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Uptake and function of anthrax toxins

Uptake and function of anthrax toxins
1306
set Uptake and function of anthrax toxins
setSize 10
pANOVA 0.0192
s.dist 0.428
p.adjustANOVA 0.0756



Top enriched genes

Top 20 genes
GeneID Gene Rank
FURIN 10311
MAP2K6 10292
MAP2K1 10244
MAP2K3 9766
PDCD6IP 8553
MAP2K2 5079
MAP2K4 4579
MAP2K7 1099
ANTXR2 775
CALM1 -5150

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FURIN 10311
MAP2K6 10292
MAP2K1 10244
MAP2K3 9766
PDCD6IP 8553
MAP2K2 5079
MAP2K4 4579
MAP2K7 1099
ANTXR2 775
CALM1 -5150


Detoxification of Reactive Oxygen Species

Detoxification of Reactive Oxygen Species
277
set Detoxification of Reactive Oxygen Species
setSize 32
pANOVA 3.05e-05
s.dist 0.426
p.adjustANOVA 0.000433



Top enriched genes

Top 20 genes
GeneID Gene Rank
NCF2 11041
NCF4 10873
GSR 10772
PRDX3 10709
CYBA 10617
CYBB 10196
P4HB 9433
CAT 9425
GPX3 9342
PRDX5 8681
TXN 8653
SOD2 8563
TXNRD1 8216
NOX4 8004
NOX5 7998
TXNRD2 7888
NCF1 7481
ATOX1 6597
ERO1A 6518
GPX2 6305

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NCF2 11041
NCF4 10873
GSR 10772
PRDX3 10709
CYBA 10617
CYBB 10196
P4HB 9433
CAT 9425
GPX3 9342
PRDX5 8681
TXN 8653
SOD2 8563
TXNRD1 8216
NOX4 8004
NOX5 7998
TXNRD2 7888
NCF1 7481
ATOX1 6597
ERO1A 6518
GPX2 6305
PRDX1 5934
TXN2 5240
GPX1 5066
ATP7A 2494
CCS 2233
NUDT2 1834
GSTP1 1776
PRDX6 -823
PRDX2 -4140
CYCS -4630
SOD1 -5860
GPX7 -9452


G1/S-Specific Transcription

G1/S-Specific Transcription
418
set G1/S-Specific Transcription
setSize 29
pANOVA 7.21e-05
s.dist -0.426
p.adjustANOVA 0.00091



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBL2 -9700
POLA1 -9660
TFDP2 -9444
FBXO5 -9228
LIN9 -8001
E2F6 -7656
PCNA -6841
RBL1 -6718
TYMS -5813
RRM2 -5738
CDC45 -5643
CDK1 -5568
LIN52 -5480
CDC6 -5479
E2F5 -5304
ORC1 -5158
RBBP4 -4658
CDT1 -4032
LIN54 -3805
CCNE1 -2791

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBL2 -9700
POLA1 -9660
TFDP2 -9444
FBXO5 -9228
LIN9 -8001
E2F6 -7656
PCNA -6841
RBL1 -6718
TYMS -5813
RRM2 -5738
CDC45 -5643
CDK1 -5568
LIN52 -5480
CDC6 -5479
E2F5 -5304
ORC1 -5158
RBBP4 -4658
CDT1 -4032
LIN54 -3805
CCNE1 -2791
CDC25A -2547
CCNA1 -2231
E2F1 -108
TK1 2257
HDAC1 2347
TFDP1 4357
LIN37 5346
E2F4 5439
DHFR 5520


Signal transduction by L1

Signal transduction by L1
1072
set Signal transduction by L1
setSize 20
pANOVA 0.00101
s.dist 0.424
p.adjustANOVA 0.00772



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAC1 10907
MAPK1 10847
PAK1 10704
MAP2K1 10244
ITGA5 10158
FGFR1 10016
MAPK3 9636
ITGAV 8115
CSNK2A1 7984
ITGA9 7799
VAV2 7476
CSNK2B 6563
NRP1 5491
MAP2K2 5079
CSNK2A2 4323
ITGA2B 1927
L1CAM -1644
ITGB3 -2871
ITGB1 -4850
NCAM1 -7535

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAC1 10907
MAPK1 10847
PAK1 10704
MAP2K1 10244
ITGA5 10158
FGFR1 10016
MAPK3 9636
ITGAV 8115
CSNK2A1 7984
ITGA9 7799
VAV2 7476
CSNK2B 6563
NRP1 5491
MAP2K2 5079
CSNK2A2 4323
ITGA2B 1927
L1CAM -1644
ITGB3 -2871
ITGB1 -4850
NCAM1 -7535


RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases
886
set RHO GTPases Activate NADPH Oxidases
setSize 21
pANOVA 0.000813
s.dist 0.422
p.adjustANOVA 0.0066



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRKCD 11506
S100A9 11432
S100A8 11315
NCF2 11041
RAC1 10907
NCF4 10873
MAPK1 10847
CYBA 10617
MAPK14 10466
CYBB 10196
MAPK3 9636
NCF1 7481
PRKCB 7102
RAC2 5082
PIN1 202
MAPK11 -273
NOXA1 -3249
PIK3C3 -3291
PIK3R4 -4411
PRKCA -5667

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRKCD 11506
S100A9 11432
S100A8 11315
NCF2 11041
RAC1 10907
NCF4 10873
MAPK1 10847
CYBA 10617
MAPK14 10466
CYBB 10196
MAPK3 9636
NCF1 7481
PRKCB 7102
RAC2 5082
PIN1 202
MAPK11 -273
NOXA1 -3249
PIK3C3 -3291
PIK3R4 -4411
PRKCA -5667
PRKCZ -6483


Metabolism of non-coding RNA

Metabolism of non-coding RNA
644
set Metabolism of non-coding RNA
setSize 53
pANOVA 1.11e-07
s.dist -0.421
p.adjustANOVA 2.87e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
GEMIN4 -9746
NUP35 -9626
NUP88 -9430
DDX20 -9102
NUP107 -8801
SEH1L -8792
NUP160 -8699
PHAX -8612
NCBP2 -8212
NUP43 -7792
NUP155 -7633
GEMIN5 -7299
NUP188 -7295
NUP205 -7051
SNRPE -6979
WDR77 -6973
SNRPF -6725
GEMIN8 -6108
POM121C -6074

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
GEMIN4 -9746
NUP35 -9626
NUP88 -9430
DDX20 -9102
NUP107 -8801
SEH1L -8792
NUP160 -8699
PHAX -8612
NCBP2 -8212
NUP43 -7792
NUP155 -7633
GEMIN5 -7299
NUP188 -7295
NUP205 -7051
SNRPE -6979
WDR77 -6973
SNRPF -6725
GEMIN8 -6108
POM121C -6074
CLNS1A -5864
NUP133 -5674
TGS1 -5399
NUP54 -5340
SNRPD2 -4757
SMN1 -4719
NUP153 -4433
SNRPD3 -4404
NUP210 -4373
TPR -4127
SNRPD1 -3757
SNRPB -3546
NUP93 -3163
RANBP2 -3109
GEMIN6 -2834
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
NCBP1 -1125
GEMIN2 -805
NUP98 175
NUP62 395
AAAS 627
PRMT5 1768
SNRPG 3835
GEMIN7 4800
SNUPN 4907
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


snRNP Assembly

snRNP Assembly
1356
set snRNP Assembly
setSize 53
pANOVA 1.11e-07
s.dist -0.421
p.adjustANOVA 2.87e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
GEMIN4 -9746
NUP35 -9626
NUP88 -9430
DDX20 -9102
NUP107 -8801
SEH1L -8792
NUP160 -8699
PHAX -8612
NCBP2 -8212
NUP43 -7792
NUP155 -7633
GEMIN5 -7299
NUP188 -7295
NUP205 -7051
SNRPE -6979
WDR77 -6973
SNRPF -6725
GEMIN8 -6108
POM121C -6074

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
GEMIN4 -9746
NUP35 -9626
NUP88 -9430
DDX20 -9102
NUP107 -8801
SEH1L -8792
NUP160 -8699
PHAX -8612
NCBP2 -8212
NUP43 -7792
NUP155 -7633
GEMIN5 -7299
NUP188 -7295
NUP205 -7051
SNRPE -6979
WDR77 -6973
SNRPF -6725
GEMIN8 -6108
POM121C -6074
CLNS1A -5864
NUP133 -5674
TGS1 -5399
NUP54 -5340
SNRPD2 -4757
SMN1 -4719
NUP153 -4433
SNRPD3 -4404
NUP210 -4373
TPR -4127
SNRPD1 -3757
SNRPB -3546
NUP93 -3163
RANBP2 -3109
GEMIN6 -2834
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
NCBP1 -1125
GEMIN2 -805
NUP98 175
NUP62 395
AAAS 627
PRMT5 1768
SNRPG 3835
GEMIN7 4800
SNUPN 4907
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Transcription of E2F targets under negative control by DREAM complex

Transcription of E2F targets under negative control by DREAM complex
1249
set Transcription of E2F targets under negative control by DREAM complex
setSize 19
pANOVA 0.00151
s.dist -0.42
p.adjustANOVA 0.0102



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBL2 -9700
TFDP2 -9444
MYC -9418
LIN9 -8001
PCNA -6841
RBL1 -6718
LIN52 -5480
CDC6 -5479
E2F5 -5304
RBBP4 -4658
MAX -4483
TOP2A -4125
LIN54 -3805
CDC25A -2547
E2F1 -108
HDAC1 2347
TFDP1 4357
LIN37 5346
E2F4 5439

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBL2 -9700
TFDP2 -9444
MYC -9418
LIN9 -8001
PCNA -6841
RBL1 -6718
LIN52 -5480
CDC6 -5479
E2F5 -5304
RBBP4 -4658
MAX -4483
TOP2A -4125
LIN54 -3805
CDC25A -2547
E2F1 -108
HDAC1 2347
TFDP1 4357
LIN37 5346
E2F4 5439


WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4
1324
set WNT5A-dependent internalization of FZD4
setSize 13
pANOVA 0.00874
s.dist 0.42
p.adjustANOVA 0.0434



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2A1 11707
ARRB2 11021
AP2A2 10434
AP2S1 9504
CLTC 9346
CLTB 8275
CLTA 7680
AP2M1 7323
PRKCB 7102
FZD4 3002
AP2B1 -3690
DVL2 -4905
PRKCA -5667

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2A1 11707
ARRB2 11021
AP2A2 10434
AP2S1 9504
CLTC 9346
CLTB 8275
CLTA 7680
AP2M1 7323
PRKCB 7102
FZD4 3002
AP2B1 -3690
DVL2 -4905
PRKCA -5667


RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate WASPs and WAVEs
888
set RHO GTPases Activate WASPs and WAVEs
setSize 35
pANOVA 2.11e-05
s.dist 0.415
p.adjustANOVA 0.000316



Top enriched genes

Top 20 genes
GeneID Gene Rank
WASF1 11510
NCKAP1L 11401
BTK 11379
WAS 11238
ARPC1A 11206
CYFIP1 11117
ARPC1B 10956
GRB2 10925
RAC1 10907
MAPK1 10847
ACTB 10419
WASF2 10259
ARPC5 10048
MAPK3 9636
ARPC3 9484
ARPC4 9223
ARPC2 9212
ACTG1 8547
NCKAP1 7871
ABI1 7663

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
WASF1 11510
NCKAP1L 11401
BTK 11379
WAS 11238
ARPC1A 11206
CYFIP1 11117
ARPC1B 10956
GRB2 10925
RAC1 10907
MAPK1 10847
ACTB 10419
WASF2 10259
ARPC5 10048
MAPK3 9636
ARPC3 9484
ARPC4 9223
ARPC2 9212
ACTG1 8547
NCKAP1 7871
ABI1 7663
ACTR2 7352
CDC42 7337
WIPF2 6706
ACTR3 6644
ABL1 4039
BAIAP2 -1231
WASL -1370
BRK1 -2011
PTK2 -3332
WIPF1 -3530
CYFIP2 -4772
WASF3 -6482
NCKIPSD -6991
ABI2 -7811
NCK1 -8821


Polymerase switching on the C-strand of the telomere

Polymerase switching on the C-strand of the telomere
835
set Polymerase switching on the C-strand of the telomere
setSize 26
pANOVA 0.000249
s.dist -0.415
p.adjustANOVA 0.00245



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
STN1 -9499
CHTF18 -8785
RFC3 -8694
PRIM1 -8268
CTC1 -8006
RFC4 -7736
DSCC1 -7671
PCNA -6841
POLA2 -6222
POT1 -5841
PRIM2 -5653
RFC1 -5493
TERF2 -4926
RFC5 -3986
ACD -3963
TERF1 -3813
TERF2IP -1108
CHTF8 -503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
STN1 -9499
CHTF18 -8785
RFC3 -8694
PRIM1 -8268
CTC1 -8006
RFC4 -7736
DSCC1 -7671
PCNA -6841
POLA2 -6222
POT1 -5841
PRIM2 -5653
RFC1 -5493
TERF2 -4926
RFC5 -3986
ACD -3963
TERF1 -3813
TERF2IP -1108
CHTF8 -503
POLD1 646
TEN1 1027
RFC2 4835
TINF2 5948
POLD4 10344
POLD3 11274


Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
345
set Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize 11
pANOVA 0.0172
s.dist 0.415
p.adjustANOVA 0.0707



Top enriched genes

Top 20 genes
GeneID Gene Rank
LYN 10893
EPOR 10373
GAB1 9727
IRS2 9312
PIK3R5 6963
PIK3CD 6507
PIK3CG 6350
PIK3CB 6109
JAK2 3783
PIK3CA -1131
PIK3R1 -9306

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
LYN 10893
EPOR 10373
GAB1 9727
IRS2 9312
PIK3R5 6963
PIK3CD 6507
PIK3CG 6350
PIK3CB 6109
JAK2 3783
PIK3CA -1131
PIK3R1 -9306


Nuclear import of Rev protein

Nuclear import of Rev protein
752
set Nuclear import of Rev protein
setSize 34
pANOVA 2.89e-05
s.dist -0.414
p.adjustANOVA 0.000414



Top enriched genes

Top 20 genes
GeneID Gene Rank
NPM1 -9836
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
TPR -4127
NUP93 -3163
RANBP2 -3109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NPM1 -9836
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
TPR -4127
NUP93 -3163
RANBP2 -3109
RCC1 -3085
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
KPNB1 -109
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Platelet sensitization by LDL

Platelet sensitization by LDL
832
set Platelet sensitization by LDL
setSize 16
pANOVA 0.0042
s.dist 0.413
p.adjustANOVA 0.0236



Top enriched genes

Top 20 genes
GeneID Gene Rank
FGR 11610
PECAM1 11314
PTPN6 11254
PPP2R5B 10579
MAPK14 10466
LRP8 10317
PLA2G4A 9943
PPP2R5A 7512
PPP2CB 5377
PPP2CA 4882
PPP2R1A 4593
PTPN11 2859
PPP2R5D 2555
PPP2R1B -2904
PPP2R5E -6283
PPP2R5C -7679

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FGR 11610
PECAM1 11314
PTPN6 11254
PPP2R5B 10579
MAPK14 10466
LRP8 10317
PLA2G4A 9943
PPP2R5A 7512
PPP2CB 5377
PPP2CA 4882
PPP2R1A 4593
PTPN11 2859
PPP2R5D 2555
PPP2R1B -2904
PPP2R5E -6283
PPP2R5C -7679


NEP/NS2 Interacts with the Cellular Export Machinery

NEP/NS2 Interacts with the Cellular Export Machinery
695
set NEP/NS2 Interacts with the Cellular Export Machinery
setSize 32
pANOVA 6.13e-05
s.dist -0.409
p.adjustANOVA 0.000811



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
XPO1 -4204
TPR -4127
NUP93 -3163
RANBP2 -3109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
NUP43 -7792
NUP155 -7633
RAN -7577
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
XPO1 -4204
TPR -4127
NUP93 -3163
RANBP2 -3109
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Hyaluronan metabolism

Hyaluronan metabolism
503
set Hyaluronan metabolism
setSize 15
pANOVA 0.00674
s.dist 0.404
p.adjustANOVA 0.0351



Top enriched genes

Top 20 genes
GeneID Gene Rank
HYAL2 11702
SLC9A1 11489
GUSB 11435
LYVE1 10683
CHP1 9397
HYAL1 8617
CD44 8470
HEXB 6925
STAB2 5526
ABCC5 1819
HYAL3 304
HAS3 259
HEXA -442
CEMIP -3222
HMMR -3479

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
HYAL2 11702
SLC9A1 11489
GUSB 11435
LYVE1 10683
CHP1 9397
HYAL1 8617
CD44 8470
HEXB 6925
STAB2 5526
ABCC5 1819
HYAL3 304
HAS3 259
HEXA -442
CEMIP -3222
HMMR -3479


Translesion synthesis by POLI

Translesion synthesis by POLI
1273
set Translesion synthesis by POLI
setSize 17
pANOVA 0.00441
s.dist -0.399
p.adjustANOVA 0.0248



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPA1 -9657
RPS27A -8722
RFC3 -8694
RPA3 -8069
RFC4 -7736
REV1 -7246
PCNA -6841
RFC1 -5493
RPA2 -4620
REV3L -4275
RFC5 -3986
UBB -2442
UBA52 -1437
POLI 2898
RFC2 4835
UBC 4874
MAD2L2 9187

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPA1 -9657
RPS27A -8722
RFC3 -8694
RPA3 -8069
RFC4 -7736
REV1 -7246
PCNA -6841
RFC1 -5493
RPA2 -4620
REV3L -4275
RFC5 -3986
UBB -2442
UBA52 -1437
POLI 2898
RFC2 4835
UBC 4874
MAD2L2 9187


Translation

Translation
1268
set Translation
setSize 295
pANOVA 4.36e-32
s.dist -0.398
p.adjustANOVA 9.91e-30



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
EEF1A1 -9389
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
NARS2 -9337
GFM1 -9259
RPS3A -9257
MRPS30 -9238
MRPS6 -9227
RPS6 -9170
RPL7 -9134
EEF1B2 -9090
RPL4 -9065
EARS2 -8978
EEF1G -8961
RPL22 -8915
N6AMT1 -8889

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL3 -9701
RPS2 -9635
RPL14 -9390
EEF1A1 -9389
RPL23A -9382
RPL5 -9359
EIF4A2 -9355
NARS2 -9337
GFM1 -9259
RPS3A -9257
MRPS30 -9238
MRPS6 -9227
RPS6 -9170
RPL7 -9134
EEF1B2 -9090
RPL4 -9065
EARS2 -8978
EEF1G -8961
RPL22 -8915
N6AMT1 -8889
LARS1 -8879
EIF3B -8874
MRPS33 -8868
RPS3 -8856
RPS25 -8832
MRPL50 -8779
RPL21 -8773
RPS27A -8722
IARS1 -8710
RPS5 -8698
RPLP0 -8691
RPL12 -8689
RPL13A -8688
EIF3E -8600
SRPRB -8515
FARS2 -8512
RPL6 -8498
RPL34 -8489
RPS20 -8476
RPL17 -8462
RPL27A -8420
RPS12 -8401
EIF1AX -8394
MRPS18B -8387
MRPS27 -8372
RPS14 -8337
GSPT2 -8336
RPS23 -8334
EIF4B -8328
RPL10 -8318
LARS2 -8305
RPS27 -8260
RPLP2 -8255
RPL36A -8130
MARS2 -8117
RPS7 -8047
RPL35A -8046
RPL10A -7989
RPL29 -7954
MRPL17 -7946
RPL11 -7928
RPL32 -7914
RPS15A -7912
TRAM1 -7911
RPL22L1 -7828
MRPS25 -7801
RPL30 -7783
RPL18 -7781
MRPL46 -7776
EIF3L -7766
RPL35 -7710
AARS2 -7669
RPL26 -7648
KARS1 -7645
RPS4X -7636
RPS10 -7629
RPL24 -7626
FARSB -7620
RPS16 -7617
RPL18A -7609
WARS2 -7547
RPL31 -7521
MRPS17 -7515
MRPL49 -7488
RPL9 -7451
AARS1 -7422
RPL15 -7380
RPS13 -7375
MRPL24 -7374
RPL7A -7296
RPS18 -7288
MRPL48 -7205
RPS8 -7161
RPS17 -7134
EEF2 -7073
RPL19 -7006
RPL23 -6933
EPRS1 -6849
RPS29 -6791
MRPL3 -6766
DARS1 -6758
RPS11 -6742
RPS21 -6706
RPL37 -6660
EEF1A1P5 -6596
RPL38 -6589
GSPT1 -6576
MRPL38 -6536
MT-RNR1 -6484
MRPL1 -6477
MRPS9 -6468
MRPS14 -6456
RPS28 -6429
SARS1 -6425
RPL36 -6343
MRPL35 -6300
RPL8 -6274
MRPL45 -6248
MRPS2 -6123
RPL27 -6068
RPL41 -6065
SARS2 -6041
EIF3J -6001
MRPL9 -5999
DAP3 -5995
EIF5B -5931
EIF3H -5894
RPL39 -5790
EIF3M -5620
RPS19 -5616
MRPL32 -5558
RPL13 -5550
RPS26 -5524
PPA1 -5482
RPS15 -5342
RPS24 -5310
MRPL42 -5308
SEC11C -5303
MRPL54 -5211
AIMP1 -5088
MRPL11 -5071
MRPS7 -5007
EEF1D -4995
EIF2B3 -4898
SRP72 -4824
HARS1 -4780
RPL37A -4774
IARS2 -4691
PTCD3 -4586
RPSA -4559
MRPL14 -4414
SRP9 -4398
MRPL39 -4366
MRPS12 -4356
VARS2 -4343
EIF3D -4337
RPL36AL -4148
MRPL30 -4147
MRPS31 -4116
MRPL19 -4110
MRPS28 -3921
MRPL34 -3892
RPLP1 -3887
EIF3C -3750
EIF3F -3748
PARS2 -3729
MRPL43 -3700
MRPL55 -3601
PABPC1 -3482
TSFM -3472
MRPL12 -3417
MRPL15 -3362
EIF2S1 -3350
MRPS10 -3348
SEC61A2 -3262
QARS1 -3062
MRPS35 -3044
MRPL41 -2920
PPA2 -2874
MRPS21 -2793
EIF3I -2671
SSR1 -2645
AIMP2 -2623
MRPL57 -2601
YARS2 -2577
SRP68 -2562
SPCS2 -2449
EIF2B5 -2425
MRRF -2404
SSR2 -2362
SEC61G -2328
MRPS22 -2326
MRPL37 -2251
MRPS26 -2022
SPCS1 -2007
RPL28 -1952
EEF1A2 -1947
SPCS3 -1816
VARS1 -1755
GADD45GIP1 -1746
EIF3G -1676
MRPS23 -1564
EIF3A -1537
FARSA -1474
MRPL47 -1448
UBA52 -1437
RARS1 -1110
FAU -1029
MRPL58 -1009
MRPS34 -978
MRPL2 -971
TARS1 -811
MRPL27 -697
SSR3 -664
SRP19 -483
EIF5 -416
TRMT112 -370
GFM2 -362
MRPS16 -360
EIF3K -298
MT-RNR2 -141
RARS2 -78
RPL39L -69
NARS1 -55
MTFMT 190
MRPL18 194
MRPL40 273
EIF2S2 297
MRPS18C 334
MTIF2 475
MRPS15 1207
MRPL21 1215
EIF2S3 1308
MRPS36 1368
RPS4Y1 1461
EIF2B1 1607
MRPL13 1696
MRPL20 1881
MRPL22 1912
SSR4 1961
EIF4E 2104
EEF1E1 2209
MRPL44 2241
MRPL36 2321
YARS1 2340
RPS9 2392
MRPS18A 2478
MRPS24 2522
MRPL4 2604
RPS27L 2784
DARS2 2882
ERAL1 3081
MRPL16 3317
SEC61A1 3976
MTIF3 3990
RPN1 4038
MRPL51 4065
ETF1 4300
OXA1L 4368
MTRF1L 4426
APEH 4454
MT-TV 4515
SEC61B 4523
MRPS11 4616
MRPL33 4926
SRP14 5005
HARS2 5027
EIF2B2 5069
GARS1 5314
MRPL10 5324
EIF4EBP1 5335
TARS2 5460
AURKAIP1 5462
SRPRA 5496
RPL3L 5700
MRPS5 5888
EIF4A1 5928
CHCHD1 6111
RPL26L1 6187
TUFM 6200
SRP54 6468
EIF2B4 6686
MRPL23 6696
RPN2 7108
SEC11A 7174
WARS1 7325
EIF4H 7435
MRPL53 7456
DDOST 7465
MRPL52 8490
MARS1 9700
CARS2 9768
EIF4G1 9922
MRPL28 10313
CARS1 10957


Processive synthesis on the C-strand of the telomere

Processive synthesis on the C-strand of the telomere
858
set Processive synthesis on the C-strand of the telomere
setSize 19
pANOVA 0.00278
s.dist -0.396
p.adjustANOVA 0.017



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
RPA1 -9657
WRN -9097
LIG1 -8618
RPA3 -8069
FEN1 -7122
PCNA -6841
POT1 -5841
TERF2 -4926
RPA2 -4620
BLM -4432
DNA2 -4017
ACD -3963
TERF1 -3813
TERF2IP -1108
POLD1 646
TINF2 5948
POLD4 10344
POLD3 11274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
RPA1 -9657
WRN -9097
LIG1 -8618
RPA3 -8069
FEN1 -7122
PCNA -6841
POT1 -5841
TERF2 -4926
RPA2 -4620
BLM -4432
DNA2 -4017
ACD -3963
TERF1 -3813
TERF2IP -1108
POLD1 646
TINF2 5948
POLD4 10344
POLD3 11274


Pre-NOTCH Processing in Golgi

Pre-NOTCH Processing in Golgi
846
set Pre-NOTCH Processing in Golgi
setSize 18
pANOVA 0.00381
s.dist 0.394
p.adjustANOVA 0.022



Top enriched genes

Top 20 genes
GeneID Gene Rank
NOTCH3 11733
NOTCH4 11483
FURIN 10311
ATP2A2 9686
ATP2A1 8605
NOTCH2 8499
ST3GAL4 8130
RAB6A 7579
NOTCH1 6982
LFNG 6750
B4GALT1 5109
SEL1L 4716
RFNG 4234
ST3GAL6 3540
TMED2 965
ATP2A3 -2610
ST3GAL3 -5182
MFNG -7131

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NOTCH3 11733
NOTCH4 11483
FURIN 10311
ATP2A2 9686
ATP2A1 8605
NOTCH2 8499
ST3GAL4 8130
RAB6A 7579
NOTCH1 6982
LFNG 6750
B4GALT1 5109
SEL1L 4716
RFNG 4234
ST3GAL6 3540
TMED2 965
ATP2A3 -2610
ST3GAL3 -5182
MFNG -7131


G0 and Early G1

G0 and Early G1
414
set G0 and Early G1
setSize 27
pANOVA 0.000438
s.dist -0.391
p.adjustANOVA 0.00378



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBL2 -9700
TFDP2 -9444
MYC -9418
LIN9 -8001
PCNA -6841
RBL1 -6718
CDK1 -5568
LIN52 -5480
CDC6 -5479
E2F5 -5304
MYBL2 -4826
RBBP4 -4658
MAX -4483
TOP2A -4125
LIN54 -3805
CDK2 -3694
DYRK1A -3079
CCNE1 -2791
CDC25A -2547
CCNA1 -2231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBL2 -9700
TFDP2 -9444
MYC -9418
LIN9 -8001
PCNA -6841
RBL1 -6718
CDK1 -5568
LIN52 -5480
CDC6 -5479
E2F5 -5304
MYBL2 -4826
RBBP4 -4658
MAX -4483
TOP2A -4125
LIN54 -3805
CDK2 -3694
DYRK1A -3079
CCNE1 -2791
CDC25A -2547
CCNA1 -2231
CCNA2 -1727
E2F1 -108
HDAC1 2347
CCNE2 3704
TFDP1 4357
LIN37 5346
E2F4 5439


PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
800
set PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
setSize 13
pANOVA 0.015
s.dist 0.39
p.adjustANOVA 0.0635



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAC1 10907
ELMO2 9846
CRK 9373
PTK6 8980
RHOA 8752
DOCK1 8538
PXN 8537
RASA1 6726
KRAS 3113
NRAS 1826
ELMO1 -1412
HRAS -3116
ARHGAP35 -5181

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAC1 10907
ELMO2 9846
CRK 9373
PTK6 8980
RHOA 8752
DOCK1 8538
PXN 8537
RASA1 6726
KRAS 3113
NRAS 1826
ELMO1 -1412
HRAS -3116
ARHGAP35 -5181


Transport of Ribonucleoproteins into the Host Nucleus

Transport of Ribonucleoproteins into the Host Nucleus
1284
set Transport of Ribonucleoproteins into the Host Nucleus
setSize 32
pANOVA 0.000146
s.dist -0.388
p.adjustANOVA 0.00167



Top enriched genes

Top 20 genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
NUP43 -7792
NUP155 -7633
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
KPNA1 -4278
TPR -4127
NUP93 -3163
RANBP2 -3109
NUP42 -2718

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NDC1 -9817
NUP35 -9626
NUP88 -9430
NUP107 -8801
SEH1L -8792
NUP160 -8699
NUP43 -7792
NUP155 -7633
NUP188 -7295
NUP205 -7051
POM121C -6074
NUP133 -5674
NUP54 -5340
NUP153 -4433
NUP210 -4373
KPNA1 -4278
TPR -4127
NUP93 -3163
RANBP2 -3109
NUP42 -2718
POM121 -2295
NUP85 -1717
NUP37 -1424
NUP50 -1242
KPNB1 -109
NUP98 175
NUP62 395
AAAS 627
RAE1 5040
SEC13 6793
NUP58 7628
NUP214 10124


Classical antibody-mediated complement activation

Classical antibody-mediated complement activation
188
set Classical antibody-mediated complement activation
setSize 69
pANOVA 2.98e-08
s.dist -0.386
p.adjustANOVA 9.02e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9443
IGLV6-57 -8979
IGLV5-45 -8955
IGLV2-18 -8778
IGLV2-14 -8599
IGHV3-33 -8574
IGKV1-16 -8350
IGLV3-21 -8327
IGLV3-1 -8150
IGKV3-15 -7683
IGHV1-69 -7589
IGLV3-12 -7540
IGLV2-8 -7468
IGKV1-5 -7365
IGLV3-19 -7358
IGKV4-1 -7302
IGLV7-46 -6955
IGHV3-53 -6692
IGHV4-34 -6614
IGHV2-5 -6583

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9443
IGLV6-57 -8979
IGLV5-45 -8955
IGLV2-18 -8778
IGLV2-14 -8599
IGHV3-33 -8574
IGKV1-16 -8350
IGLV3-21 -8327
IGLV3-1 -8150
IGKV3-15 -7683
IGHV1-69 -7589
IGLV3-12 -7540
IGLV2-8 -7468
IGKV1-5 -7365
IGLV3-19 -7358
IGKV4-1 -7302
IGLV7-46 -6955
IGHV3-53 -6692
IGHV4-34 -6614
IGHV2-5 -6583
IGHV3-48 -5881
IGLC7 -5764
IGLV3-27 -5637
IGHV3-23 -5636
IGLV8-61 -5601
IGHV1-2 -5526
IGLV1-51 -5296
IGKC -5232
IGHV3-7 -5228
IGLC2 -5138
IGKV3-20 -5082
IGKV1-33 -4953
IGHV4-39 -4884
IGHV3-30 -4685
IGLV1-47 -4485
IGKV1-12 -4392
IGKV2-28 -4281
IGLC1 -4280
IGHV2-70 -4223
IGHG3 -4128
IGHV3-11 -3626
IGHV1-46 -3558
IGLV4-69 -3305
IGHG2 -3113
IGLV1-40 -3024
IGKV2-30 -2958
IGKV1-17 -2929
IGHV4-59 -2340
IGLV1-36 -2214
IGLV3-25 -1935
IGHV3-13 -1600
IGHG1 -1504
IGLV1-44 -1090
IGHG4 -760
IGKV2D-28 -728
IGLC3 -403
IGKV3D-20 -305
IGLV10-54 -276
IGLV2-23 1244
C1S 2813
IGKV5-2 3051
IGLV2-11 3601
IGKV1D-39 3771
C1R 4413
IGLV7-43 7123
IGKV1-39 9771
C1QA 11453
C1QC 11693
C1QB 11723


Scavenging of heme from plasma

Scavenging of heme from plasma
1056
set Scavenging of heme from plasma
setSize 71
pANOVA 2.01e-08
s.dist -0.385
p.adjustANOVA 6.23e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
IGKV3-11 -9443
IGLV6-57 -8979
IGLV5-45 -8955
IGLV2-18 -8778
IGLV2-14 -8599
IGHV3-33 -8574
IGKV1-16 -8350
IGLV3-21 -8327
IGLV3-1 -8150
IGKV3-15 -7683
JCHAIN -7676
IGHV1-69 -7589
IGLV3-12 -7540
IGLV2-8 -7468
IGKV1-5 -7365
IGLV3-19 -7358
IGKV4-1 -7302
IGLV7-46 -6955
IGHV3-53 -6692
IGHV4-34 -6614

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IGKV3-11 -9443
IGLV6-57 -8979
IGLV5-45 -8955
IGLV2-18 -8778
IGLV2-14 -8599
IGHV3-33 -8574
IGKV1-16 -8350
IGLV3-21 -8327
IGLV3-1 -8150
IGKV3-15 -7683
JCHAIN -7676
IGHV1-69 -7589
IGLV3-12 -7540
IGLV2-8 -7468
IGKV1-5 -7365
IGLV3-19 -7358
IGKV4-1 -7302
IGLV7-46 -6955
IGHV3-53 -6692
IGHV4-34 -6614
IGHV2-5 -6583
IGHV3-48 -5881
IGLC7 -5764
IGLV3-27 -5637
IGHV3-23 -5636
IGLV8-61 -5601
IGHV1-2 -5526
IGLV1-51 -5296
IGHA1 -5247
IGKC -5232
IGHV3-7 -5228
IGLC2 -5138
IGKV3-20 -5082
IGKV1-33 -4953
IGHV4-39 -4884
IGHV3-30 -4685
IGLV1-47 -4485
IGKV1-12 -4392
IGKV2-28 -4281
IGLC1 -4280
IGHV2-70 -4223
IGHV3-11 -3626
IGHV1-46 -3558
IGLV4-69 -3305
IGLV1-40 -3024
IGKV2-30 -2958
IGKV1-17 -2929
HPX -2463
IGHV4-59 -2340
IGLV1-36 -2214
IGHA2 -2084
IGLV3-25 -1935
IGHV3-13 -1600
IGLV1-44 -1090
HBA1 -867
IGKV2D-28 -728
IGLC3 -403
IGKV3D-20 -305
IGLV10-54 -276
HBB -79
IGLV2-23 1244
APOL1 1736
IGKV5-2 3051
IGLV2-11 3601
IGKV1D-39 3771
IGLV7-43 7123
ALB 9450
IGKV1-39 9771
LRP1 11120
CD163 11297
HP 11572


Leading Strand Synthesis

Leading Strand Synthesis
595
set Leading Strand Synthesis
setSize 14
pANOVA 0.0126
s.dist -0.385
p.adjustANOVA 0.0558



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RFC3 -8694
PRIM1 -8268
RFC4 -7736
PCNA -6841
POLA2 -6222
PRIM2 -5653
RFC1 -5493
RFC5 -3986
POLD1 646
RFC2 4835
POLD4 10344
POLD3 11274

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLD2 -9742
POLA1 -9660
RFC3 -8694
PRIM1 -8268
RFC4 -7736
PCNA -6841
POLA2 -6222
PRIM2 -5653
RFC1 -5493
RFC5 -3986
POLD1 646
RFC2 4835
POLD4 10344
POLD3 11274


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0               GGally_2.1.1               
##  [3] beeswarm_0.3.1              gtools_3.8.2               
##  [5] echarts4r_0.4.0             topconfects_1.6.0          
##  [7] limma_3.46.0                eulerr_6.1.0               
##  [9] mitch_1.2.2                 MASS_7.3-53.1              
## [11] fgsea_1.16.0                gplots_3.1.1               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.58.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] reshape2_1.4.4              forcats_0.5.1              
## [25] stringr_1.4.0               dplyr_1.0.5                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.3                 tibble_3.1.0               
## [31] ggplot2_3.3.3               tidyverse_1.3.0            
## [33] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_2.0.2       
##   [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.13       
##   [7] farver_2.1.0           bit64_4.0.5            AnnotationDbi_1.52.0  
##  [10] fansi_0.4.2            lubridate_1.7.10       xml2_1.3.2            
##  [13] splines_4.0.3          cachem_1.0.4           geneplotter_1.68.0    
##  [16] knitr_1.31             polyclip_1.10-0        jsonlite_1.7.2        
##  [19] broom_0.7.5            annotate_1.68.0        dbplyr_2.1.0          
##  [22] shiny_1.6.0            compiler_4.0.3         httr_1.4.2            
##  [25] backports_1.2.1        assertthat_0.2.1       Matrix_1.3-2          
##  [28] fastmap_1.1.0          cli_2.3.1              later_1.1.0.1         
##  [31] htmltools_0.5.1.1      tools_4.0.3            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
##  [37] Rcpp_1.0.6             cellranger_1.1.0       jquerylib_0.1.3       
##  [40] vctrs_0.3.6            polylabelr_0.2.0       xfun_0.22             
##  [43] ps_1.6.0               testthat_3.0.2         rvest_1.0.0           
##  [46] mime_0.10              lifecycle_1.0.0        XML_3.99-0.6          
##  [49] zlibbioc_1.36.0        scales_1.1.1           promises_1.2.0.1      
##  [52] hms_1.0.0              RColorBrewer_1.1-2     yaml_2.2.1            
##  [55] memoise_2.0.0          gridExtra_2.3          sass_0.3.1            
##  [58] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.4         
##  [61] highr_0.8              genefilter_1.72.0      desc_1.3.0            
##  [64] caTools_1.18.1         BiocParallel_1.24.1    rlang_0.4.10          
##  [67] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
##  [70] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.3     
##  [73] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
##  [76] magrittr_2.0.1         R6_2.5.0               generics_0.1.0        
##  [79] DelayedArray_0.16.0    DBI_1.1.1              pillar_1.5.1          
##  [82] haven_2.3.1            withr_2.4.1            survival_3.2-10       
##  [85] RCurl_1.98-1.3         modelr_0.1.8           crayon_1.4.1          
##  [88] KernSmooth_2.23-18     utf8_1.2.1             rmarkdown_2.7         
##  [91] locfit_1.5-9.4         grid_4.0.3             readxl_1.3.1          
##  [94] data.table_1.14.0      blob_1.2.1             reprex_1.0.0          
##  [97] digest_0.6.27          xtable_1.8-4           httpuv_1.5.5          
## [100] munsell_0.5.0          bslib_0.2.4

END of report