date generated: 2021-04-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   x
## A1BG     -3.0045626
## A1BG-AS1 -0.6855588
## A1CF      0.3272035
## A2M       1.6308274
## A2M-AS1   1.0554888
## A2ML1     1.0055621

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genesets 2408
num_genes_in_profile 22124
duplicated_genes_present 0
num_profile_genes_in_sets 8463
num_profile_genes_not_in_sets 13661

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1041
num_genesets_included 1367

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 100 gene sets

set setSize pANOVA s.dist p.adjustANOVA
Peptide chain elongation 88 6.36e-25 -0.635 4.35e-22
Eukaryotic Translation Elongation 93 5.98e-26 -0.631 8.18e-23
Viral mRNA Translation 88 1.04e-22 -0.604 2.37e-20
Eukaryotic Translation Termination 92 5.46e-23 -0.595 1.87e-20
Selenocysteine synthesis 92 8.98e-23 -0.592 2.37e-20
Formation of a pool of free 40S subunits 100 1.32e-23 -0.579 6.02e-21
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 1.41e-20 -0.554 2.75e-18
Incretin synthesis, secretion, and inactivation 10 3.60e-03 0.532 4.06e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 3.60e-03 0.532 4.06e-02
NF-kB is activated and signals survival 12 2.07e-03 -0.513 2.81e-02
WNT5A-dependent internalization of FZD4 13 1.53e-03 -0.508 2.37e-02
L13a-mediated translational silencing of Ceruloplasmin expression 110 5.78e-20 -0.504 9.88e-18
DNA methylation 20 1.26e-04 -0.495 2.88e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.78e-17 -0.492 2.02e-15
VLDLR internalisation and degradation 11 5.00e-03 -0.489 5.10e-02
tRNA processing in the mitochondrion 32 1.71e-06 -0.489 5.69e-05
GTP hydrolysis and joining of the 60S ribosomal subunit 111 6.92e-19 -0.487 1.05e-16
AKT phosphorylates targets in the nucleus 10 8.21e-03 -0.483 6.81e-02
CDC6 association with the ORC:origin complex 11 5.97e-03 0.479 5.62e-02
Josephin domain DUBs 10 8.89e-03 -0.478 7.10e-02
Cytosolic iron-sulfur cluster assembly 13 3.62e-03 -0.466 4.06e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 4.58e-17 -0.455 4.47e-15
Nonsense-Mediated Decay (NMD) 114 4.58e-17 -0.455 4.47e-15
Cap-dependent Translation Initiation 118 1.45e-17 -0.454 1.80e-15
Eukaryotic Translation Initiation 118 1.45e-17 -0.454 1.80e-15
Formation of the ternary complex, and subsequently, the 43S complex 51 4.73e-08 -0.442 2.31e-06
GP1b-IX-V activation signalling 10 1.56e-02 -0.442 1.02e-01
RNA Polymerase I Promoter Opening 19 1.00e-03 -0.436 1.67e-02
Condensation of Prometaphase Chromosomes 11 1.25e-02 0.435 8.83e-02
Trafficking of GluR2-containing AMPA receptors 12 9.31e-03 -0.433 7.28e-02
Regulation of FZD by ubiquitination 16 2.72e-03 -0.433 3.38e-02
Presynaptic phase of homologous DNA pairing and strand exchange 39 3.16e-06 0.431 9.81e-05
SUMOylation of DNA methylation proteins 16 3.05e-03 -0.428 3.69e-02
Selenoamino acid metabolism 114 6.82e-15 -0.422 6.22e-13
Processing and activation of SUMO 10 2.18e-02 0.419 1.32e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.48e-13 -0.406 1.13e-11
Olfactory Signaling Pathway 61 5.11e-08 0.403 2.41e-06
Homologous DNA Pairing and Strand Exchange 42 6.30e-06 0.403 1.91e-04
FOXO-mediated transcription of cell death genes 16 5.58e-03 -0.400 5.34e-02
A tetrasaccharide linker sequence is required for GAG synthesis 18 3.39e-03 -0.399 3.92e-02
rRNA processing in the mitochondrion 29 2.27e-04 -0.395 4.68e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 6.39e-03 -0.394 5.83e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.08e-07 -0.391 8.61e-06
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.49e-02 -0.391 1.47e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 1.93e-02 -0.390 1.21e-01
Pexophagy 11 2.51e-02 -0.390 1.47e-01
Translation initiation complex formation 58 2.90e-07 -0.389 1.17e-05
Influenza Viral RNA Transcription and Replication 135 9.54e-15 -0.386 7.67e-13
MET activates RAP1 and RAC1 10 3.51e-02 0.385 1.83e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 7.29e-04 0.383 1.26e-02
Signaling by Leptin 10 3.70e-02 -0.381 1.88e-01
Ribosomal scanning and start codon recognition 58 5.74e-07 -0.379 2.12e-05
Pausing and recovery of Tat-mediated HIV elongation 30 3.24e-04 -0.379 5.90e-03
Tat-mediated HIV elongation arrest and recovery 30 3.24e-04 -0.379 5.90e-03
HS-GAG degradation 16 8.72e-03 -0.379 7.10e-02
Interleukin-2 signaling 11 3.16e-02 -0.374 1.73e-01
p75NTR signals via NF-kB 15 1.27e-02 -0.372 8.87e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 2.55e-03 -0.372 3.29e-02
Activation of Matrix Metalloproteinases 24 1.64e-03 -0.371 2.47e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 2.71e-02 -0.369 1.54e-01
Diseases of hemostasis 12 2.71e-02 -0.369 1.54e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 3.12e-02 0.359 1.72e-01
Establishment of Sister Chromatid Cohesion 11 3.99e-02 0.358 1.94e-01
Pre-NOTCH Processing in Golgi 18 9.04e-03 -0.355 7.14e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 2.16e-02 -0.355 1.31e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 2.16e-02 -0.355 1.31e-01
HDR through Single Strand Annealing (SSA) 37 1.89e-04 0.355 4.03e-03
p75NTR recruits signalling complexes 12 3.54e-02 -0.351 1.83e-01
RMTs methylate histone arginines 37 2.31e-04 -0.350 4.68e-03
Heparan sulfate/heparin (HS-GAG) metabolism 38 2.32e-04 -0.345 4.68e-03
Regulation of IFNG signaling 14 2.55e-02 0.345 1.47e-01
Synthesis of PIPs at the late endosome membrane 11 4.79e-02 0.344 2.19e-01
Collagen chain trimerization 27 1.98e-03 -0.344 2.76e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 5.33e-03 -0.343 5.16e-02
Plasma lipoprotein clearance 29 1.47e-03 -0.341 2.34e-02
IRAK4 deficiency (TLR2/4) 10 6.21e-02 0.341 2.56e-01
MyD88 deficiency (TLR2/4) 10 6.21e-02 0.341 2.56e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 2.70e-03 -0.340 3.38e-02
Regulation of localization of FOXO transcription factors 12 4.48e-02 -0.335 2.10e-01
Retrograde neurotrophin signalling 12 4.65e-02 -0.332 2.16e-01
Lewis blood group biosynthesis 13 3.89e-02 -0.331 1.92e-01
Cleavage of the damaged purine 24 5.20e-03 -0.329 5.12e-02
Depurination 24 5.20e-03 -0.329 5.12e-02
Recognition and association of DNA glycosylase with site containing an affected purine 24 5.20e-03 -0.329 5.12e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 6.29e-03 -0.329 5.77e-02
Biosynthesis of DHA-derived SPMs 14 3.36e-02 -0.328 1.79e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 4.15e-04 -0.327 7.37e-03
Common Pathway of Fibrin Clot Formation 14 3.59e-02 -0.324 1.84e-01
Packaging Of Telomere Ends 20 1.22e-02 -0.324 8.74e-02
Downregulation of ERBB2:ERBB3 signaling 12 5.33e-02 -0.322 2.35e-01
HIV elongation arrest and recovery 32 1.64e-03 -0.322 2.47e-02
Pausing and recovery of HIV elongation 32 1.64e-03 -0.322 2.47e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 1.33e-02 -0.320 9.12e-02
NGF-stimulated transcription 33 1.49e-03 -0.320 2.34e-02
EGFR downregulation 27 4.23e-03 -0.318 4.63e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 1.94e-03 -0.317 2.73e-02
Cyclin A/B1/B2 associated events during G2/M transition 24 7.49e-03 0.315 6.40e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.30e-02 -0.313 8.95e-02
Formation of ATP by chemiosmotic coupling 18 2.16e-02 -0.313 1.31e-01
Influenza Infection 154 2.27e-11 -0.312 1.41e-09


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
Peptide chain elongation 88 6.36e-25 -0.635000 4.35e-22
Eukaryotic Translation Elongation 93 5.98e-26 -0.631000 8.18e-23
Viral mRNA Translation 88 1.04e-22 -0.604000 2.37e-20
Eukaryotic Translation Termination 92 5.46e-23 -0.595000 1.87e-20
Selenocysteine synthesis 92 8.98e-23 -0.592000 2.37e-20
Formation of a pool of free 40S subunits 100 1.32e-23 -0.579000 6.02e-21
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 1.41e-20 -0.554000 2.75e-18
Incretin synthesis, secretion, and inactivation 10 3.60e-03 0.532000 4.06e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 3.60e-03 0.532000 4.06e-02
NF-kB is activated and signals survival 12 2.07e-03 -0.513000 2.81e-02
WNT5A-dependent internalization of FZD4 13 1.53e-03 -0.508000 2.37e-02
L13a-mediated translational silencing of Ceruloplasmin expression 110 5.78e-20 -0.504000 9.88e-18
DNA methylation 20 1.26e-04 -0.495000 2.88e-03
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.78e-17 -0.492000 2.02e-15
VLDLR internalisation and degradation 11 5.00e-03 -0.489000 5.10e-02
tRNA processing in the mitochondrion 32 1.71e-06 -0.489000 5.69e-05
GTP hydrolysis and joining of the 60S ribosomal subunit 111 6.92e-19 -0.487000 1.05e-16
AKT phosphorylates targets in the nucleus 10 8.21e-03 -0.483000 6.81e-02
CDC6 association with the ORC:origin complex 11 5.97e-03 0.479000 5.62e-02
Josephin domain DUBs 10 8.89e-03 -0.478000 7.10e-02
Cytosolic iron-sulfur cluster assembly 13 3.62e-03 -0.466000 4.06e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 4.58e-17 -0.455000 4.47e-15
Nonsense-Mediated Decay (NMD) 114 4.58e-17 -0.455000 4.47e-15
Cap-dependent Translation Initiation 118 1.45e-17 -0.454000 1.80e-15
Eukaryotic Translation Initiation 118 1.45e-17 -0.454000 1.80e-15
Formation of the ternary complex, and subsequently, the 43S complex 51 4.73e-08 -0.442000 2.31e-06
GP1b-IX-V activation signalling 10 1.56e-02 -0.442000 1.02e-01
RNA Polymerase I Promoter Opening 19 1.00e-03 -0.436000 1.67e-02
Condensation of Prometaphase Chromosomes 11 1.25e-02 0.435000 8.83e-02
Trafficking of GluR2-containing AMPA receptors 12 9.31e-03 -0.433000 7.28e-02
Regulation of FZD by ubiquitination 16 2.72e-03 -0.433000 3.38e-02
Presynaptic phase of homologous DNA pairing and strand exchange 39 3.16e-06 0.431000 9.81e-05
SUMOylation of DNA methylation proteins 16 3.05e-03 -0.428000 3.69e-02
Selenoamino acid metabolism 114 6.82e-15 -0.422000 6.22e-13
Processing and activation of SUMO 10 2.18e-02 0.419000 1.32e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.48e-13 -0.406000 1.13e-11
Olfactory Signaling Pathway 61 5.11e-08 0.403000 2.41e-06
Homologous DNA Pairing and Strand Exchange 42 6.30e-06 0.403000 1.91e-04
FOXO-mediated transcription of cell death genes 16 5.58e-03 -0.400000 5.34e-02
A tetrasaccharide linker sequence is required for GAG synthesis 18 3.39e-03 -0.399000 3.92e-02
rRNA processing in the mitochondrion 29 2.27e-04 -0.395000 4.68e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 6.39e-03 -0.394000 5.83e-02
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.08e-07 -0.391000 8.61e-06
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 2.49e-02 -0.391000 1.47e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 1.93e-02 -0.390000 1.21e-01
Pexophagy 11 2.51e-02 -0.390000 1.47e-01
Translation initiation complex formation 58 2.90e-07 -0.389000 1.17e-05
Influenza Viral RNA Transcription and Replication 135 9.54e-15 -0.386000 7.67e-13
MET activates RAP1 and RAC1 10 3.51e-02 0.385000 1.83e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 7.29e-04 0.383000 1.26e-02
Signaling by Leptin 10 3.70e-02 -0.381000 1.88e-01
Ribosomal scanning and start codon recognition 58 5.74e-07 -0.379000 2.12e-05
Pausing and recovery of Tat-mediated HIV elongation 30 3.24e-04 -0.379000 5.90e-03
Tat-mediated HIV elongation arrest and recovery 30 3.24e-04 -0.379000 5.90e-03
HS-GAG degradation 16 8.72e-03 -0.379000 7.10e-02
Interleukin-2 signaling 11 3.16e-02 -0.374000 1.73e-01
p75NTR signals via NF-kB 15 1.27e-02 -0.372000 8.87e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 2.55e-03 -0.372000 3.29e-02
Activation of Matrix Metalloproteinases 24 1.64e-03 -0.371000 2.47e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 2.71e-02 -0.369000 1.54e-01
Diseases of hemostasis 12 2.71e-02 -0.369000 1.54e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 3.12e-02 0.359000 1.72e-01
Establishment of Sister Chromatid Cohesion 11 3.99e-02 0.358000 1.94e-01
Pre-NOTCH Processing in Golgi 18 9.04e-03 -0.355000 7.14e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 2.16e-02 -0.355000 1.31e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 2.16e-02 -0.355000 1.31e-01
HDR through Single Strand Annealing (SSA) 37 1.89e-04 0.355000 4.03e-03
p75NTR recruits signalling complexes 12 3.54e-02 -0.351000 1.83e-01
RMTs methylate histone arginines 37 2.31e-04 -0.350000 4.68e-03
Heparan sulfate/heparin (HS-GAG) metabolism 38 2.32e-04 -0.345000 4.68e-03
Regulation of IFNG signaling 14 2.55e-02 0.345000 1.47e-01
Synthesis of PIPs at the late endosome membrane 11 4.79e-02 0.344000 2.19e-01
Collagen chain trimerization 27 1.98e-03 -0.344000 2.76e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 5.33e-03 -0.343000 5.16e-02
Plasma lipoprotein clearance 29 1.47e-03 -0.341000 2.34e-02
IRAK4 deficiency (TLR2/4) 10 6.21e-02 0.341000 2.56e-01
MyD88 deficiency (TLR2/4) 10 6.21e-02 0.341000 2.56e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 2.70e-03 -0.340000 3.38e-02
Regulation of localization of FOXO transcription factors 12 4.48e-02 -0.335000 2.10e-01
Retrograde neurotrophin signalling 12 4.65e-02 -0.332000 2.16e-01
Lewis blood group biosynthesis 13 3.89e-02 -0.331000 1.92e-01
Cleavage of the damaged purine 24 5.20e-03 -0.329000 5.12e-02
Depurination 24 5.20e-03 -0.329000 5.12e-02
Recognition and association of DNA glycosylase with site containing an affected purine 24 5.20e-03 -0.329000 5.12e-02
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 6.29e-03 -0.329000 5.77e-02
Biosynthesis of DHA-derived SPMs 14 3.36e-02 -0.328000 1.79e-01
Chondroitin sulfate/dermatan sulfate metabolism 39 4.15e-04 -0.327000 7.37e-03
Common Pathway of Fibrin Clot Formation 14 3.59e-02 -0.324000 1.84e-01
Packaging Of Telomere Ends 20 1.22e-02 -0.324000 8.74e-02
Downregulation of ERBB2:ERBB3 signaling 12 5.33e-02 -0.322000 2.35e-01
HIV elongation arrest and recovery 32 1.64e-03 -0.322000 2.47e-02
Pausing and recovery of HIV elongation 32 1.64e-03 -0.322000 2.47e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 1.33e-02 -0.320000 9.12e-02
NGF-stimulated transcription 33 1.49e-03 -0.320000 2.34e-02
EGFR downregulation 27 4.23e-03 -0.318000 4.63e-02
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 1.94e-03 -0.317000 2.73e-02
Cyclin A/B1/B2 associated events during G2/M transition 24 7.49e-03 0.315000 6.40e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.30e-02 -0.313000 8.95e-02
Formation of ATP by chemiosmotic coupling 18 2.16e-02 -0.313000 1.31e-01
Influenza Infection 154 2.27e-11 -0.312000 1.41e-09
E2F mediated regulation of DNA replication 22 1.13e-02 0.312000 8.29e-02
Regulation of expression of SLITs and ROBOs 162 7.62e-12 -0.312000 5.21e-10
Abortive elongation of HIV-1 transcript in the absence of Tat 23 9.92e-03 -0.311000 7.59e-02
Collagen biosynthesis and modifying enzymes 46 2.92e-04 -0.309000 5.46e-03
Regulation of TP53 Activity through Association with Co-factors 12 6.47e-02 -0.308000 2.64e-01
Glycogen storage diseases 13 5.47e-02 -0.308000 2.36e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 9.26e-02 0.307000 3.33e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 6.01e-03 -0.305000 5.62e-02
Diseases of carbohydrate metabolism 29 4.52e-03 -0.305000 4.83e-02
rRNA processing 219 8.59e-15 -0.304000 7.34e-13
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 8.43e-02 0.301000 3.16e-01
Glycogen synthesis 13 6.35e-02 -0.297000 2.60e-01
N-Glycan antennae elongation 13 6.35e-02 -0.297000 2.60e-01
PKA activation in glucagon signalling 14 5.46e-02 -0.297000 2.36e-01
Synthesis of IP3 and IP4 in the cytosol 22 1.60e-02 -0.297000 1.05e-01
Repression of WNT target genes 14 5.51e-02 -0.296000 2.36e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 6.06e-03 -0.294000 5.64e-02
Collagen formation 64 4.87e-05 -0.294000 1.26e-03
GAB1 signalosome 15 4.91e-02 -0.293000 2.22e-01
Nuclear Receptor transcription pathway 41 1.19e-03 -0.293000 1.94e-02
Chondroitin sulfate biosynthesis 13 6.81e-02 -0.292000 2.74e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 9.16e-03 -0.290000 7.20e-02
rRNA processing in the nucleus and cytosol 190 6.12e-12 -0.289000 4.40e-10
CD28 dependent PI3K/Akt signaling 22 1.89e-02 -0.289000 1.20e-01
Inhibition of DNA recombination at telomere 35 3.14e-03 -0.288000 3.71e-02
PKA activation 15 5.36e-02 -0.288000 2.35e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 2.80e-11 -0.287000 1.67e-09
Antiviral mechanism by IFN-stimulated genes 80 9.57e-06 0.286000 2.78e-04
Defective B3GAT3 causes JDSSDHD 12 8.64e-02 -0.286000 3.21e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.20e-02 -0.284000 8.67e-02
EPH-ephrin mediated repulsion of cells 40 2.04e-03 -0.282000 2.81e-02
Interferon alpha/beta signaling 57 2.33e-04 0.282000 4.68e-03
Defective B3GALT6 causes EDSP2 and SEMDJL1 12 9.41e-02 -0.279000 3.33e-01
NS1 Mediated Effects on Host Pathways 40 2.37e-03 0.278000 3.12e-02
Resolution of D-loop Structures through Holliday Junction Intermediates 32 6.63e-03 0.277000 5.92e-02
Spry regulation of FGF signaling 16 5.56e-02 -0.276000 2.38e-01
Effects of PIP2 hydrolysis 24 1.92e-02 -0.276000 1.20e-01
Defective B4GALT7 causes EDS, progeroid type 12 1.01e-01 -0.274000 3.43e-01
Base-Excision Repair, AP Site Formation 31 8.35e-03 -0.274000 6.88e-02
Regulation of TP53 Activity through Acetylation 29 1.09e-02 -0.273000 8.09e-02
Regulation of TLR by endogenous ligand 11 1.22e-01 0.269000 3.75e-01
Negative regulation of FGFR4 signaling 21 3.27e-02 -0.269000 1.78e-01
HSF1-dependent transactivation 29 1.24e-02 -0.268000 8.82e-02
Collagen degradation 29 1.24e-02 -0.268000 8.82e-02
Assembly of collagen fibrils and other multimeric structures 42 2.66e-03 -0.268000 3.38e-02
Cytochrome c-mediated apoptotic response 13 9.45e-02 0.268000 3.33e-01
Downregulation of ERBB2 signaling 24 2.38e-02 -0.267000 1.43e-01
Signaling by PDGFRA extracellular domain mutants 12 1.13e-01 0.264000 3.62e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.13e-01 0.264000 3.62e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 6.83e-02 -0.263000 2.74e-01
Formation of the beta-catenin:TCF transactivating complex 46 2.09e-03 -0.262000 2.81e-02
Mucopolysaccharidoses 11 1.34e-01 -0.261000 3.91e-01
Other semaphorin interactions 16 7.10e-02 -0.261000 2.81e-01
Hyaluronan metabolism 13 1.05e-01 -0.260000 3.51e-01
Gap junction trafficking 14 9.23e-02 -0.260000 3.33e-01
Signal regulatory protein family interactions 12 1.20e-01 -0.259000 3.72e-01
Acetylcholine Neurotransmitter Release Cycle 11 1.36e-01 -0.259000 3.92e-01
NRIF signals cell death from the nucleus 15 8.41e-02 -0.258000 3.16e-01
Elevation of cytosolic Ca2+ levels 13 1.09e-01 -0.257000 3.57e-01
Deadenylation of mRNA 22 3.81e-02 0.255000 1.89e-01
Transport of the SLBP Dependant Mature mRNA 36 8.17e-03 0.255000 6.81e-02
Signaling by ROBO receptors 202 4.30e-10 -0.255000 2.26e-08
Activation of ATR in response to replication stress 36 8.52e-03 0.253000 6.98e-02
The role of Nef in HIV-1 replication and disease pathogenesis 28 2.06e-02 -0.253000 1.27e-01
Degradation of cysteine and homocysteine 13 1.15e-01 -0.252000 3.65e-01
IRAK2 mediated activation of TAK1 complex 10 1.68e-01 -0.252000 4.46e-01
Senescence-Associated Secretory Phenotype (SASP) 66 4.07e-04 -0.252000 7.32e-03
Signaling by NODAL 13 1.17e-01 -0.251000 3.68e-01
Resolution of D-Loop Structures 33 1.29e-02 0.250000 8.95e-02
ISG15 antiviral mechanism 72 2.56e-04 0.249000 5.00e-03
Resolution of Sister Chromatid Cohesion 104 1.13e-05 0.249000 3.09e-04
Signaling by NOTCH3 43 5.11e-03 -0.247000 5.12e-02
AKT phosphorylates targets in the cytosol 14 1.11e-01 -0.246000 3.59e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 4.58e-02 -0.246000 2.14e-01
Transport of the SLBP independent Mature mRNA 35 1.27e-02 0.243000 8.87e-02
Response of EIF2AK1 (HRI) to heme deficiency 14 1.15e-01 0.243000 3.65e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.79e-02 0.242000 1.15e-01
Assembly Of The HIV Virion 15 1.05e-01 -0.242000 3.51e-01
TRAF6 mediated IRF7 activation 15 1.06e-01 0.241000 3.51e-01
Negative regulation of FGFR3 signaling 20 6.18e-02 -0.241000 2.56e-01
Neurexins and neuroligins 38 1.04e-02 -0.240000 7.79e-02
Gluconeogenesis 28 2.80e-02 -0.240000 1.58e-01
Cleavage of the damaged pyrimidine 29 2.54e-02 -0.240000 1.47e-01
Depyrimidination 29 2.54e-02 -0.240000 1.47e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 2.54e-02 -0.240000 1.47e-01
Glycogen metabolism 23 4.69e-02 -0.239000 2.16e-01
Amyloid fiber formation 51 3.17e-03 -0.239000 3.71e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 1.95e-02 0.238000 1.21e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 2.68e-03 -0.238000 3.38e-02
Notch-HLH transcription pathway 28 2.91e-02 -0.238000 1.63e-01
HDACs deacetylate histones 47 5.00e-03 -0.237000 5.10e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 7.38e-03 0.236000 6.35e-02
Pre-NOTCH Transcription and Translation 49 4.34e-03 -0.236000 4.71e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.58e-01 0.235000 4.32e-01
Platelet Aggregation (Plug Formation) 28 3.28e-02 -0.233000 1.78e-01
TBC/RABGAPs 45 6.96e-03 -0.232000 6.10e-02
Plasma lipoprotein assembly, remodeling, and clearance 54 3.17e-03 -0.232000 3.71e-02
Glycosaminoglycan metabolism 93 1.14e-04 -0.232000 2.68e-03
Translation of structural proteins 28 3.47e-02 -0.231000 1.82e-01
Interleukin-7 signaling 21 6.76e-02 -0.230000 2.74e-01
Nuclear Events (kinase and transcription factor activation) 55 3.17e-03 -0.230000 3.71e-02
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 1.50e-04 0.230000 3.30e-03
Amplification of signal from the kinetochores 91 1.50e-04 0.230000 3.30e-03
MicroRNA (miRNA) biogenesis 24 5.30e-02 -0.228000 2.35e-01
SUMOylation of ubiquitinylation proteins 39 1.38e-02 0.228000 9.38e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.12e-02 0.226000 8.28e-02
HS-GAG biosynthesis 20 8.02e-02 -0.226000 3.06e-01
Pre-NOTCH Expression and Processing 65 1.70e-03 -0.225000 2.50e-02
Cristae formation 31 3.02e-02 -0.225000 1.68e-01
Basigin interactions 23 6.24e-02 -0.224000 2.57e-01
Laminin interactions 21 7.51e-02 -0.224000 2.91e-01
Gap junction trafficking and regulation 16 1.21e-01 -0.224000 3.74e-01
HDR through MMEJ (alt-NHEJ) 10 2.20e-01 0.224000 5.11e-01
Termination of O-glycan biosynthesis 16 1.23e-01 -0.223000 3.76e-01
Interferon Signaling 177 3.30e-07 0.222000 1.29e-05
NR1H2 and NR1H3-mediated signaling 40 1.49e-02 -0.222000 1.00e-01
Mitotic Spindle Checkpoint 108 6.77e-05 0.222000 1.65e-03
Cohesin Loading onto Chromatin 10 2.26e-01 0.221000 5.18e-01
Processing of Intronless Pre-mRNAs 19 9.60e-02 0.221000 3.34e-01
Nuclear signaling by ERBB4 24 6.19e-02 -0.220000 2.56e-01
Norepinephrine Neurotransmitter Release Cycle 13 1.71e-01 -0.219000 4.50e-01
Hyaluronan uptake and degradation 10 2.30e-01 -0.219000 5.24e-01
Signaling by PDGFR in disease 19 9.90e-02 0.219000 3.40e-01
MASTL Facilitates Mitotic Progression 10 2.32e-01 0.218000 5.27e-01
Regulation of TP53 Activity through Methylation 19 1.01e-01 -0.217000 3.43e-01
PKA-mediated phosphorylation of CREB 17 1.21e-01 -0.217000 3.74e-01
Signaling by NOTCH2 30 3.97e-02 -0.217000 1.94e-01
Pyrimidine salvage 10 2.35e-01 -0.217000 5.28e-01
Cell-extracellular matrix interactions 14 1.61e-01 -0.216000 4.37e-01
EML4 and NUDC in mitotic spindle formation 95 2.77e-04 0.216000 5.30e-03
CaM pathway 27 5.36e-02 -0.215000 2.35e-01
Calmodulin induced events 27 5.36e-02 -0.215000 2.35e-01
Assembly of active LPL and LIPC lipase complexes 11 2.19e-01 -0.214000 5.10e-01
Activation of HOX genes during differentiation 71 1.82e-03 -0.214000 2.61e-02
Activation of anterior HOX genes in hindbrain development during early embryogenesis 71 1.82e-03 -0.214000 2.61e-02
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 3.08e-02 -0.214000 1.71e-01
Metabolism of fat-soluble vitamins 28 5.07e-02 -0.213000 2.27e-01
NOTCH4 Intracellular Domain Regulates Transcription 18 1.18e-01 -0.213000 3.69e-01
Activation of RAC1 11 2.21e-01 0.213000 5.13e-01
Insulin processing 20 9.95e-02 0.213000 3.41e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 4.06e-02 0.213000 1.95e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 4.06e-02 0.213000 1.95e-01
Nuclear Pore Complex (NPC) Disassembly 36 2.76e-02 0.212000 1.56e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 2.45e-01 -0.212000 5.35e-01
Defective EXT2 causes exostoses 2 10 2.45e-01 -0.212000 5.35e-01
Response of Mtb to phagocytosis 22 8.68e-02 -0.211000 3.21e-01
Retinoid metabolism and transport 24 7.37e-02 -0.211000 2.88e-01
Export of Viral Ribonucleoproteins from Nucleus 33 3.60e-02 0.211000 1.84e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 9.46e-02 -0.211000 3.33e-01
Signaling by EGFR 46 1.39e-02 -0.210000 9.38e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 15 1.60e-01 -0.210000 4.34e-01
NRAGE signals death through JNK 52 9.45e-03 -0.208000 7.30e-02
PRC2 methylates histones and DNA 29 5.30e-02 -0.208000 2.35e-01
SUMOylation of DNA replication proteins 46 1.51e-02 0.207000 1.00e-01
RHO GTPases Activate NADPH Oxidases 21 1.02e-01 -0.206000 3.44e-01
Disorders of Developmental Biology 12 2.18e-01 -0.206000 5.08e-01
Disorders of Nervous System Development 12 2.18e-01 -0.206000 5.08e-01
Loss of function of MECP2 in Rett syndrome 12 2.18e-01 -0.206000 5.08e-01
Pervasive developmental disorders 12 2.18e-01 -0.206000 5.08e-01
Negative regulation of FGFR1 signaling 24 8.17e-02 -0.205000 3.09e-01
Plasma lipoprotein assembly 11 2.40e-01 -0.205000 5.33e-01
Metabolism of non-coding RNA 53 1.01e-02 0.204000 7.64e-02
snRNP Assembly 53 1.01e-02 0.204000 7.64e-02
Adenylate cyclase inhibitory pathway 11 2.41e-01 -0.204000 5.35e-01
Acyl chain remodelling of PG 11 2.41e-01 0.204000 5.35e-01
SUMOylation of immune response proteins 11 2.42e-01 -0.204000 5.35e-01
Extracellular matrix organization 220 1.90e-07 -0.204000 8.10e-06
Pentose phosphate pathway 13 2.04e-01 -0.204000 4.93e-01
G2/M DNA damage checkpoint 67 4.09e-03 0.203000 4.51e-02
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 1.89e-01 -0.203000 4.79e-01
Metabolism of Angiotensinogen to Angiotensins 11 2.46e-01 -0.202000 5.35e-01
Antimicrobial peptides 34 4.20e-02 -0.201000 2.00e-01
Uptake and function of anthrax toxins 10 2.72e-01 -0.201000 5.67e-01
CRMPs in Sema3A signaling 14 1.94e-01 -0.200000 4.84e-01
Cytosolic tRNA aminoacylation 24 9.08e-02 0.199000 3.31e-01
Purine catabolism 16 1.67e-01 -0.199000 4.46e-01
DAG and IP3 signaling 33 4.75e-02 -0.199000 2.18e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 2.75e-01 -0.199000 5.70e-01
HDR through Homologous Recombination (HRR) 66 5.12e-03 0.199000 5.12e-02
Phosphorylation of the APC/C 20 1.24e-01 0.199000 3.78e-01
Attenuation phase 23 9.97e-02 -0.198000 3.41e-01
Other interleukin signaling 18 1.46e-01 -0.198000 4.08e-01
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.35e-01 0.198000 5.28e-01
alpha-linolenic acid (ALA) metabolism 12 2.35e-01 0.198000 5.28e-01
PI3K/AKT Signaling in Cancer 81 2.10e-03 -0.198000 2.81e-02
LDL clearance 17 1.58e-01 -0.198000 4.32e-01
Complex I biogenesis 55 1.14e-02 -0.197000 8.33e-02
Regulation of PTEN gene transcription 59 8.92e-03 -0.197000 7.10e-02
Rap1 signalling 13 2.19e-01 0.197000 5.11e-01
tRNA processing in the nucleus 59 8.94e-03 0.197000 7.10e-02
Regulation of TP53 Activity through Phosphorylation 89 1.35e-03 0.197000 2.16e-02
Leading Strand Synthesis 14 2.03e-01 0.197000 4.93e-01
Polymerase switching 14 2.03e-01 0.197000 4.93e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 4.26e-02 -0.195000 2.02e-01
Blood group systems biosynthesis 17 1.64e-01 -0.195000 4.40e-01
Nuclear import of Rev protein 34 4.95e-02 0.195000 2.23e-01
Maturation of nucleoprotein 10 2.87e-01 0.194000 5.74e-01
Endosomal/Vacuolar pathway 12 2.45e-01 -0.194000 5.35e-01
Membrane binding and targetting of GAG proteins 13 2.26e-01 -0.194000 5.18e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 2.26e-01 -0.194000 5.18e-01
RORA activates gene expression 18 1.54e-01 -0.194000 4.26e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 49 1.90e-02 0.194000 1.20e-01
Metabolism of porphyrins 22 1.17e-01 -0.193000 3.68e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.26e-01 0.193000 3.81e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.26e-01 0.193000 3.81e-01
ATF6 (ATF6-alpha) activates chaperones 12 2.51e-01 0.192000 5.41e-01
Synthesis of PC 23 1.12e-01 0.191000 3.61e-01
Defects in cobalamin (B12) metabolism 13 2.33e-01 0.191000 5.27e-01
Activation of G protein gated Potassium channels 20 1.41e-01 0.190000 3.99e-01
G protein gated Potassium channels 20 1.41e-01 0.190000 3.99e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 1.41e-01 0.190000 3.99e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 1.41e-01 0.190000 3.99e-01
SIRT1 negatively regulates rRNA expression 24 1.07e-01 -0.190000 3.54e-01
Diseases associated with glycosaminoglycan metabolism 27 8.81e-02 -0.190000 3.23e-01
Regulation of innate immune responses to cytosolic DNA 14 2.22e-01 -0.189000 5.13e-01
Cell Cycle Checkpoints 259 1.77e-07 0.188000 8.06e-06
Chemokine receptors bind chemokines 40 3.93e-02 -0.188000 1.92e-01
SUMOylation of SUMOylation proteins 35 5.47e-02 0.188000 2.36e-01
MET activates RAS signaling 10 3.05e-01 0.187000 5.97e-01
Separation of Sister Chromatids 168 2.91e-05 0.187000 7.65e-04
Negative regulation of FGFR2 signaling 23 1.21e-01 -0.187000 3.75e-01
Vpr-mediated nuclear import of PICs 34 6.02e-02 0.186000 2.54e-01
Arachidonic acid metabolism 44 3.29e-02 -0.186000 1.78e-01
Deactivation of the beta-catenin transactivating complex 36 5.51e-02 -0.185000 2.36e-01
Long-term potentiation 15 2.16e-01 -0.184000 5.08e-01
HDMs demethylate histones 22 1.36e-01 -0.184000 3.92e-01
Inositol phosphate metabolism 43 3.74e-02 -0.183000 1.88e-01
Synthesis of PIPs at the early endosome membrane 16 2.04e-01 0.183000 4.93e-01
Condensation of Prophase Chromosomes 29 8.79e-02 -0.183000 3.23e-01
Formation of Incision Complex in GG-NER 43 3.81e-02 0.183000 1.89e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 4.08e-02 -0.182000 1.95e-01
HIV Transcription Elongation 42 4.08e-02 -0.182000 1.95e-01
Tat-mediated elongation of the HIV-1 transcript 42 4.08e-02 -0.182000 1.95e-01
Cell death signalling via NRAGE, NRIF and NADE 69 8.92e-03 -0.182000 7.10e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 1.40e-01 -0.182000 3.99e-01
G1/S-Specific Transcription 29 9.07e-02 0.181000 3.31e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 4.81e-04 -0.181000 8.43e-03
PIWI-interacting RNA (piRNA) biogenesis 24 1.26e-01 -0.181000 3.81e-01
Metabolism of carbohydrates 242 1.29e-06 -0.181000 4.41e-05
Tight junction interactions 19 1.73e-01 -0.180000 4.55e-01
RHO GTPases activate IQGAPs 11 3.01e-01 0.180000 5.90e-01
Cell junction organization 59 1.68e-02 -0.180000 1.10e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 1.64e-01 -0.180000 4.40e-01
Trafficking of AMPA receptors 20 1.64e-01 -0.180000 4.40e-01
Serotonin Neurotransmitter Release Cycle 14 2.45e-01 -0.179000 5.35e-01
Ephrin signaling 18 1.88e-01 -0.179000 4.78e-01
Synthesis of very long-chain fatty acyl-CoAs 22 1.46e-01 0.179000 4.08e-01
Ca-dependent events 29 9.53e-02 -0.179000 3.33e-01
Interactions of Rev with host cellular proteins 37 6.02e-02 0.179000 2.54e-01
Postmitotic nuclear pore complex (NPC) reformation 27 1.09e-01 0.178000 3.57e-01
Transcriptional Regulation by E2F6 34 7.25e-02 0.178000 2.85e-01
Pregnenolone biosynthesis 10 3.32e-01 -0.177000 6.24e-01
RNA polymerase II transcribes snRNA genes 72 9.94e-03 0.176000 7.59e-02
PERK regulates gene expression 31 9.12e-02 0.175000 3.31e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.93e-01 -0.175000 5.80e-01
Heme biosynthesis 14 2.56e-01 -0.175000 5.51e-01
Axon guidance 459 1.35e-10 -0.175000 7.40e-09
Signaling by NOTCH1 67 1.33e-02 -0.175000 9.12e-02
Mitotic Telophase/Cytokinesis 13 2.76e-01 0.174000 5.70e-01
Oxidative Stress Induced Senescence 79 7.57e-03 -0.174000 6.43e-02
Nervous system development 478 7.99e-11 -0.173000 4.55e-09
Chromatin modifying enzymes 218 1.02e-05 -0.173000 2.85e-04
Chromatin organization 218 1.02e-05 -0.173000 2.85e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 34 8.05e-02 -0.173000 3.06e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 2.82e-01 -0.172000 5.70e-01
Gastrin-CREB signalling pathway via PKC and MAPK 14 2.66e-01 -0.172000 5.62e-01
SUMOylation of transcription cofactors 44 4.87e-02 -0.172000 2.21e-01
Respiratory electron transport 101 2.90e-03 -0.171000 3.57e-02
Caspase activation via Death Receptors in the presence of ligand 16 2.35e-01 0.171000 5.28e-01
Mitotic Prometaphase 184 6.05e-05 0.171000 1.50e-03
Vitamin D (calciferol) metabolism 10 3.48e-01 -0.171000 6.34e-01
Regulation of KIT signaling 15 2.51e-01 -0.171000 5.41e-01
Branched-chain amino acid catabolism 21 1.75e-01 0.171000 4.59e-01
FGFR2 alternative splicing 25 1.39e-01 -0.171000 3.98e-01
PINK1-PRKN Mediated Mitophagy 21 1.76e-01 -0.171000 4.60e-01
Non-integrin membrane-ECM interactions 37 7.26e-02 -0.171000 2.85e-01
Intrinsic Pathway of Fibrin Clot Formation 16 2.39e-01 -0.170000 5.33e-01
Smooth Muscle Contraction 31 1.02e-01 -0.170000 3.44e-01
NOTCH3 Intracellular Domain Regulates Transcription 21 1.79e-01 -0.169000 4.65e-01
Cell-Cell communication 88 6.17e-03 -0.169000 5.70e-02
SUMOylation of transcription factors 16 2.43e-01 0.169000 5.35e-01
HATs acetylate histones 93 4.96e-03 -0.169000 5.10e-02
RUNX3 regulates NOTCH signaling 14 2.75e-01 -0.168000 5.70e-01
Mitophagy 28 1.23e-01 -0.168000 3.76e-01
Activation of SMO 13 2.94e-01 -0.168000 5.81e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 25 1.47e-01 -0.167000 4.10e-01
Glycosphingolipid metabolism 36 8.24e-02 -0.167000 3.10e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 2.47e-01 -0.167000 5.37e-01
APC/C-mediated degradation of cell cycle proteins 87 7.31e-03 0.166000 6.33e-02
Regulation of mitotic cell cycle 87 7.31e-03 0.166000 6.33e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 2.65e-01 0.166000 5.62e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 8.48e-02 0.166000 3.17e-01
Syndecan interactions 19 2.10e-01 -0.166000 5.02e-01
CASP8 activity is inhibited 11 3.41e-01 0.166000 6.27e-01
Dimerization of procaspase-8 11 3.41e-01 0.166000 6.27e-01
Regulation by c-FLIP 11 3.41e-01 0.166000 6.27e-01
Activation of the pre-replicative complex 32 1.06e-01 0.165000 3.51e-01
Signaling by FGFR4 in disease 11 3.43e-01 0.165000 6.30e-01
Rev-mediated nuclear export of HIV RNA 35 9.11e-02 0.165000 3.31e-01
Signaling by FGFR1 in disease 30 1.18e-01 0.165000 3.69e-01
Degradation of the extracellular matrix 81 1.04e-02 -0.165000 7.79e-02
ECM proteoglycans 36 8.78e-02 -0.164000 3.23e-01
G-protein mediated events 44 6.03e-02 -0.164000 2.54e-01
Signaling by FGFR2 IIIa TM 18 2.30e-01 -0.163000 5.24e-01
p75 NTR receptor-mediated signalling 88 8.08e-03 -0.163000 6.77e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 3.74e-01 0.162000 6.54e-01
RAF-independent MAPK1/3 activation 21 1.98e-01 -0.162000 4.87e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 3.52e-01 -0.162000 6.37e-01
G0 and Early G1 27 1.45e-01 0.162000 4.08e-01
Base Excision Repair 58 3.30e-02 -0.162000 1.78e-01
Integrin cell surface interactions 52 4.37e-02 -0.162000 2.06e-01
Estrogen-dependent gene expression 99 5.44e-03 -0.162000 5.23e-02
Translation 295 1.90e-06 -0.161000 6.18e-05
Golgi Cisternae Pericentriolar Stack Reorganization 14 2.96e-01 0.161000 5.84e-01
Negative regulation of the PI3K/AKT network 87 9.38e-03 -0.161000 7.28e-02
Formation of the Early Elongation Complex 33 1.10e-01 -0.161000 3.58e-01
Formation of the HIV-1 Early Elongation Complex 33 1.10e-01 -0.161000 3.58e-01
Polo-like kinase mediated events 15 2.82e-01 0.160000 5.70e-01
PECAM1 interactions 12 3.36e-01 -0.160000 6.25e-01
Cellular hexose transport 15 2.84e-01 -0.160000 5.70e-01
Protein-protein interactions at synapses 59 3.40e-02 -0.160000 1.80e-01
Lysosome Vesicle Biogenesis 32 1.20e-01 -0.159000 3.72e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 3.21e-01 0.159000 6.10e-01
Heme degradation 10 3.87e-01 -0.158000 6.62e-01
RAF activation 32 1.23e-01 0.158000 3.76e-01
Phase 4 - resting membrane potential 10 3.90e-01 0.157000 6.66e-01
Elastic fibre formation 32 1.25e-01 -0.157000 3.80e-01
Initial triggering of complement 78 1.73e-02 0.156000 1.11e-01
Platelet calcium homeostasis 22 2.06e-01 -0.156000 4.93e-01
FGFR2 mutant receptor activation 22 2.09e-01 -0.155000 5.01e-01
Synaptic adhesion-like molecules 16 2.85e-01 -0.155000 5.70e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 2.70e-01 -0.154000 5.67e-01
Signaling by NTRKs 117 3.91e-03 -0.154000 4.35e-02
cGMP effects 12 3.55e-01 -0.154000 6.39e-01
G alpha (z) signalling events 36 1.09e-01 -0.154000 3.57e-01
Processing of DNA double-strand break ends 71 2.49e-02 0.154000 1.47e-01
DNA Replication 126 3.02e-03 0.153000 3.69e-02
G2/M Checkpoints 139 1.88e-03 0.153000 2.68e-02
Signaling by NTRK1 (TRKA) 102 7.90e-03 -0.152000 6.66e-02
HSF1 activation 26 1.81e-01 -0.152000 4.67e-01
Extra-nuclear estrogen signaling 66 3.33e-02 -0.151000 1.79e-01
ESR-mediated signaling 161 9.11e-04 -0.151000 1.54e-02
PLC beta mediated events 43 8.58e-02 -0.151000 3.20e-01
Signaling by FGFR3 in disease 13 3.45e-01 0.151000 6.31e-01
Signaling by FGFR3 point mutants in cancer 13 3.45e-01 0.151000 6.31e-01
Ion homeostasis 41 9.41e-02 -0.151000 3.33e-01
Signaling by Nuclear Receptors 219 1.24e-04 -0.150000 2.88e-03
NOTCH1 Intracellular Domain Regulates Transcription 45 8.13e-02 -0.150000 3.09e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 8.66e-02 -0.149000 3.21e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 3.71e-01 -0.149000 6.52e-01
Phase 2 - plateau phase 11 3.93e-01 0.149000 6.66e-01
Late endosomal microautophagy 30 1.60e-01 -0.148000 4.34e-01
RUNX2 regulates osteoblast differentiation 19 2.64e-01 -0.148000 5.62e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 3.08e-01 -0.147000 5.98e-01
Class B/2 (Secretin family receptors) 57 5.47e-02 -0.147000 2.36e-01
PI3K Cascade 30 1.64e-01 -0.147000 4.40e-01
BBSome-mediated cargo-targeting to cilium 22 2.34e-01 0.147000 5.28e-01
APC/C:Cdc20 mediated degradation of mitotic proteins 75 2.83e-02 0.146000 1.59e-01
Infection with Mycobacterium tuberculosis 26 1.97e-01 -0.146000 4.87e-01
B-WICH complex positively regulates rRNA expression 44 9.37e-02 -0.146000 3.33e-01
TGF-beta receptor signaling activates SMADs 32 1.55e-01 -0.145000 4.27e-01
Lagging Strand Synthesis 20 2.61e-01 0.145000 5.58e-01
RHO GTPases Activate Formins 117 6.77e-03 0.145000 6.01e-02
Developmental Biology 738 2.08e-11 -0.145000 1.36e-09
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 2.52e-02 -0.145000 1.47e-01
Mitotic Metaphase and Anaphase 225 1.88e-04 0.144000 4.03e-03
Creation of C4 and C2 activators 71 3.55e-02 0.144000 1.83e-01
Glycogen breakdown (glycogenolysis) 13 3.69e-01 -0.144000 6.50e-01
Positive epigenetic regulation of rRNA expression 59 5.61e-02 -0.144000 2.39e-01
Signaling by EGFR in Cancer 23 2.33e-01 -0.144000 5.27e-01
Diseases associated with O-glycosylation of proteins 49 8.24e-02 -0.143000 3.10e-01
Plasma lipoprotein remodeling 19 2.81e-01 -0.143000 5.70e-01
Platelet Adhesion to exposed collagen 13 3.72e-01 -0.143000 6.53e-01
Nicotinamide salvaging 15 3.41e-01 0.142000 6.27e-01
ADORA2B mediated anti-inflammatory cytokines production 74 3.46e-02 -0.142000 1.82e-01
Mitochondrial protein import 64 4.96e-02 -0.142000 2.23e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 9.63e-02 -0.142000 3.34e-01
Transcriptional Regulation by MECP2 47 9.41e-02 -0.141000 3.33e-01
Signaling by WNT in cancer 30 1.81e-01 -0.141000 4.67e-01
Classical antibody-mediated complement activation 69 4.29e-02 0.141000 2.03e-01
Mitotic Anaphase 224 2.79e-04 0.141000 5.30e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 76 3.37e-02 0.141000 1.79e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 7.38e-02 -0.141000 2.88e-01
TRAF3-dependent IRF activation pathway 13 3.81e-01 0.140000 6.56e-01
Response to elevated platelet cytosolic Ca2+ 108 1.20e-02 -0.140000 8.67e-02
TP53 Regulates Transcription of Caspase Activators and Caspases 12 4.04e-01 0.139000 6.74e-01
Formation of apoptosome 11 4.25e-01 0.139000 6.85e-01
Regulation of the apoptosome activity 11 4.25e-01 0.139000 6.85e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 2.22e-01 0.138000 5.13e-01
Platelet degranulation 104 1.53e-02 -0.138000 1.01e-01
RET signaling 32 1.78e-01 -0.137000 4.65e-01
Transcriptional regulation of granulopoiesis 46 1.08e-01 -0.137000 3.57e-01
Biotin transport and metabolism 11 4.34e-01 -0.136000 6.96e-01
RNA Polymerase I Promoter Clearance 63 6.15e-02 -0.136000 2.56e-01
RNA Polymerase I Transcription 63 6.15e-02 -0.136000 2.56e-01
Scavenging of heme from plasma 71 4.85e-02 0.135000 2.21e-01
Glutamate and glutamine metabolism 12 4.17e-01 -0.135000 6.82e-01
Signaling by Receptor Tyrosine Kinases 413 2.41e-06 -0.135000 7.67e-05
G beta:gamma signalling through CDC42 17 3.35e-01 0.135000 6.25e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 4.38e-01 0.135000 6.97e-01
tRNA Aminoacylation 42 1.31e-01 0.135000 3.90e-01
Signaling by NOTCH 183 1.67e-03 -0.135000 2.49e-02
Regulation of APC/C activators between G1/S and early anaphase 80 3.79e-02 0.134000 1.89e-01
Synthesis of DNA 119 1.16e-02 0.134000 8.40e-02
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 73 4.78e-02 0.134000 2.19e-01
Transport of Mature Transcript to Cytoplasm 81 3.75e-02 0.134000 1.88e-01
Assembly and cell surface presentation of NMDA receptors 19 3.13e-01 -0.134000 6.04e-01
Regulation of Complement cascade 94 2.51e-02 0.134000 1.47e-01
Telomere Maintenance 80 3.91e-02 -0.133000 1.92e-01
Signaling by Hippo 18 3.28e-01 0.133000 6.18e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 4.46e-01 -0.133000 6.98e-01
RNA Polymerase III Chain Elongation 18 3.31e-01 -0.132000 6.22e-01
Erythrocytes take up carbon dioxide and release oxygen 11 4.49e-01 -0.132000 6.98e-01
O2/CO2 exchange in erythrocytes 11 4.49e-01 -0.132000 6.98e-01
Amino acid transport across the plasma membrane 24 2.63e-01 -0.132000 5.62e-01
Sema4D induced cell migration and growth-cone collapse 19 3.21e-01 -0.132000 6.10e-01
Constitutive Signaling by EGFRvIII 14 3.94e-01 0.131000 6.66e-01
Signaling by EGFRvIII in Cancer 14 3.94e-01 0.131000 6.66e-01
Interleukin-27 signaling 11 4.51e-01 0.131000 6.99e-01
Cellular Senescence 144 6.60e-03 -0.131000 5.92e-02
ZBP1(DAI) mediated induction of type I IFNs 20 3.11e-01 -0.131000 6.00e-01
Switching of origins to a post-replicative state 90 3.21e-02 0.131000 1.75e-01
ERKs are inactivated 13 4.17e-01 -0.130000 6.82e-01
Complement cascade 98 2.63e-02 0.130000 1.51e-01
CD28 co-stimulation 33 1.97e-01 -0.130000 4.87e-01
Activation of the AP-1 family of transcription factors 10 4.78e-01 -0.130000 7.17e-01
Interactions of Vpr with host cellular proteins 37 1.72e-01 0.130000 4.53e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 24 2.72e-01 -0.130000 5.67e-01
Cellular responses to stress 500 6.97e-07 -0.130000 2.51e-05
Cross-presentation of soluble exogenous antigens (endosomes) 48 1.20e-01 0.130000 3.74e-01
Signaling by cytosolic FGFR1 fusion mutants 17 3.56e-01 0.129000 6.39e-01
EPHB-mediated forward signaling 33 1.99e-01 0.129000 4.89e-01
Apoptotic factor-mediated response 18 3.44e-01 0.129000 6.31e-01
Nuclear Envelope Breakdown 53 1.06e-01 0.128000 3.51e-01
Glyoxylate metabolism and glycine degradation 24 2.76e-01 0.128000 5.70e-01
Cellular responses to external stimuli 506 7.84e-07 -0.128000 2.75e-05
Cargo trafficking to the periciliary membrane 47 1.28e-01 0.128000 3.87e-01
DNA Double Strand Break Response 47 1.29e-01 -0.128000 3.87e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 4.63e-01 -0.128000 7.07e-01
SHC-mediated cascade:FGFR2 12 4.44e-01 0.128000 6.98e-01
Cholesterol biosynthesis 24 2.84e-01 0.126000 5.70e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 1.90e-01 0.126000 4.80e-01
Diseases of mitotic cell cycle 36 1.90e-01 0.126000 4.80e-01
Mitotic G2-G2/M phases 181 3.43e-03 0.126000 3.94e-02
Metabolism of amino acids and derivatives 326 9.17e-05 -0.126000 2.20e-03
Signaling by Non-Receptor Tyrosine Kinases 48 1.31e-01 -0.126000 3.90e-01
Signaling by PTK6 48 1.31e-01 -0.126000 3.90e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 4.15e-01 0.126000 6.82e-01
Prolactin receptor signaling 11 4.70e-01 0.126000 7.11e-01
Oncogene Induced Senescence 33 2.11e-01 -0.126000 5.02e-01
Interleukin-4 and Interleukin-13 signaling 94 3.52e-02 -0.126000 1.83e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 4.52e-01 0.125000 7.00e-01
Orc1 removal from chromatin 70 7.02e-02 0.125000 2.79e-01
TCF dependent signaling in response to WNT 167 5.32e-03 -0.125000 5.16e-02
The citric acid (TCA) cycle and respiratory electron transport 172 4.80e-03 -0.125000 5.05e-02
Signaling by FGFR2 60 9.50e-02 -0.125000 3.33e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 4.95e-01 0.125000 7.32e-01
Nitric oxide stimulates guanylate cyclase 15 4.04e-01 -0.125000 6.74e-01
Recycling pathway of L1 26 2.72e-01 -0.124000 5.67e-01
S Phase 161 6.54e-03 0.124000 5.92e-02
Aquaporin-mediated transport 38 1.85e-01 -0.124000 4.75e-01
Keratinization 34 2.11e-01 -0.124000 5.02e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 4.57e-01 -0.124000 7.02e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 72 6.89e-02 0.124000 2.75e-01
PCP/CE pathway 87 4.60e-02 -0.124000 2.14e-01
RIP-mediated NFkB activation via ZBP1 17 3.77e-01 -0.124000 6.55e-01
Activation of BH3-only proteins 30 2.43e-01 -0.123000 5.35e-01
CDT1 association with the CDC6:ORC:origin complex 58 1.05e-01 0.123000 3.51e-01
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 4.43e-01 0.123000 6.98e-01
G2/M Transition 179 4.62e-03 0.123000 4.90e-02
Nucleobase biosynthesis 13 4.45e-01 -0.122000 6.98e-01
Interferon gamma signaling 83 5.41e-02 0.122000 2.36e-01
Glucagon signaling in metabolic regulation 27 2.74e-01 -0.122000 5.69e-01
SARS-CoV-2 Infection 63 9.51e-02 -0.122000 3.33e-01
Regulation of beta-cell development 20 3.47e-01 -0.122000 6.33e-01
G1/S Transition 130 1.69e-02 0.121000 1.10e-01
Inflammasomes 20 3.48e-01 0.121000 6.34e-01
FOXO-mediated transcription of cell cycle genes 15 4.17e-01 -0.121000 6.82e-01
Carboxyterminal post-translational modifications of tubulin 27 2.77e-01 -0.121000 5.70e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 2.77e-01 -0.121000 5.70e-01
Platelet activation, signaling and aggregation 219 2.12e-03 -0.120000 2.81e-02
DCC mediated attractive signaling 13 4.54e-01 -0.120000 7.00e-01
Signaling by ERBB2 44 1.69e-01 -0.120000 4.49e-01
CS/DS degradation 10 5.12e-01 -0.120000 7.37e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.01e-01 0.120000 5.90e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.14e-01 -0.119000 7.37e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 54 1.32e-01 -0.118000 3.90e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants 54 1.32e-01 -0.118000 3.90e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 54 1.32e-01 -0.118000 3.90e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer 54 1.32e-01 -0.118000 3.90e-01
Signaling by NOTCH1 in Cancer 54 1.32e-01 -0.118000 3.90e-01
Circadian Clock 67 9.56e-02 -0.118000 3.33e-01
Synthesis of bile acids and bile salts 24 3.18e-01 0.118000 6.08e-01
TICAM1-dependent activation of IRF3/IRF7 12 4.80e-01 -0.118000 7.19e-01
Intracellular signaling by second messengers 273 8.21e-04 -0.118000 1.40e-02
EPH-Ephrin signaling 80 6.97e-02 -0.117000 2.78e-01
Mitotic G1 phase and G1/S transition 148 1.39e-02 0.117000 9.38e-02
O-glycosylation of TSR domain-containing proteins 27 2.93e-01 -0.117000 5.80e-01
MAP2K and MAPK activation 34 2.38e-01 -0.117000 5.32e-01
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 3.67e-01 -0.116000 6.50e-01
Neurodegenerative Diseases 20 3.67e-01 -0.116000 6.50e-01
O-linked glycosylation 84 6.56e-02 -0.116000 2.67e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 2.22e-01 -0.116000 5.13e-01
Transcriptional regulation by RUNX1 185 6.97e-03 -0.115000 6.10e-02
IRAK1 recruits IKK complex 10 5.30e-01 -0.115000 7.45e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 5.30e-01 -0.115000 7.45e-01
G beta:gamma signalling through PI3Kgamma 22 3.53e-01 -0.114000 6.37e-01
Synthesis, secretion, and deacylation of Ghrelin 11 5.12e-01 0.114000 7.37e-01
Chaperone Mediated Autophagy 20 3.77e-01 -0.114000 6.55e-01
Metabolism of cofactors 19 3.90e-01 0.114000 6.66e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 9.47e-02 0.114000 3.33e-01
RUNX3 regulates p14-ARF 10 5.33e-01 -0.114000 7.48e-01
RHO GTPases activate CIT 18 4.03e-01 0.114000 6.74e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 4.17e-01 0.114000 6.82e-01
Semaphorin interactions 57 1.38e-01 -0.114000 3.95e-01
Cargo concentration in the ER 30 2.83e-01 0.113000 5.70e-01
Signaling by ERBB2 ECD mutants 15 4.48e-01 0.113000 6.98e-01
RNA Polymerase I Promoter Escape 44 1.95e-01 -0.113000 4.85e-01
Voltage gated Potassium channels 27 3.10e-01 -0.113000 6.00e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 4.99e-01 -0.113000 7.33e-01
Signaling by FGFR4 31 2.77e-01 -0.113000 5.70e-01
DNA Damage/Telomere Stress Induced Senescence 44 1.96e-01 -0.113000 4.86e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 59 1.35e-01 0.112000 3.92e-01
Suppression of phagosomal maturation 12 5.01e-01 -0.112000 7.33e-01
Tryptophan catabolism 12 5.01e-01 0.112000 7.33e-01
VEGFR2 mediated cell proliferation 18 4.10e-01 -0.112000 6.77e-01
Downregulation of TGF-beta receptor signaling 26 3.23e-01 -0.112000 6.11e-01
Visual phototransduction 60 1.34e-01 -0.112000 3.91e-01
Downstream signaling of activated FGFR2 19 3.99e-01 0.112000 6.73e-01
TP53 Regulates Transcription of DNA Repair Genes 61 1.33e-01 -0.111000 3.90e-01
DNA Replication Pre-Initiation 83 7.96e-02 0.111000 3.05e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.56e-01 -0.111000 5.50e-01
FCGR activation 76 9.47e-02 0.111000 3.33e-01
Downstream signaling of activated FGFR1 20 3.92e-01 0.111000 6.66e-01
Interleukin-12 family signaling 54 1.60e-01 0.110000 4.34e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 5.20e-02 0.110000 2.32e-01
SARS-CoV-1 Infection 47 1.92e-01 -0.110000 4.83e-01
Meiotic synapsis 45 2.02e-01 -0.110000 4.93e-01
Keratan sulfate biosynthesis 22 3.74e-01 -0.110000 6.54e-01
FRS-mediated FGFR2 signaling 14 4.81e-01 0.109000 7.19e-01
Phase I - Functionalization of compounds 64 1.33e-01 -0.109000 3.91e-01
Integrin signaling 22 3.78e-01 -0.109000 6.55e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 4.40e-01 0.108000 6.98e-01
XBP1(S) activates chaperone genes 47 2.00e-01 -0.108000 4.90e-01
Formation of the cornified envelope 21 3.92e-01 -0.108000 6.66e-01
MET activates PTK2 signaling 15 4.70e-01 -0.108000 7.11e-01
Nucleotide salvage 21 3.94e-01 -0.108000 6.66e-01
Insulin receptor signalling cascade 39 2.45e-01 -0.108000 5.35e-01
Inwardly rectifying K+ channels 24 3.62e-01 0.107000 6.47e-01
IRE1alpha activates chaperones 49 1.93e-01 -0.107000 4.83e-01
CDK-mediated phosphorylation and removal of Cdc6 72 1.15e-01 0.107000 3.65e-01
mRNA Splicing - Minor Pathway 52 1.81e-01 -0.107000 4.67e-01
ERBB2 Regulates Cell Motility 10 5.58e-01 -0.107000 7.70e-01
Fertilization 13 5.04e-01 -0.107000 7.33e-01
Trafficking and processing of endosomal TLR 13 5.05e-01 0.107000 7.33e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 4.75e-01 -0.107000 7.15e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 2.82e-01 -0.107000 5.70e-01
CD22 mediated BCR regulation 59 1.57e-01 0.106000 4.31e-01
Processing of Capped Intronless Pre-mRNA 28 3.30e-01 0.106000 6.22e-01
Dopamine Neurotransmitter Release Cycle 19 4.24e-01 -0.106000 6.85e-01
MyD88 cascade initiated on plasma membrane 82 9.78e-02 -0.106000 3.37e-01
Toll Like Receptor 10 (TLR10) Cascade 82 9.78e-02 -0.106000 3.37e-01
Toll Like Receptor 5 (TLR5) Cascade 82 9.78e-02 -0.106000 3.37e-01
G alpha (q) signalling events 134 3.47e-02 -0.106000 1.82e-01
Regulation of RUNX2 expression and activity 67 1.35e-01 0.106000 3.92e-01
Presynaptic function of Kainate receptors 18 4.38e-01 -0.106000 6.97e-01
SHC-mediated cascade:FGFR1 12 5.27e-01 0.105000 7.43e-01
Molecules associated with elastic fibres 22 3.93e-01 -0.105000 6.66e-01
Cell Cycle, Mitotic 501 5.66e-05 0.105000 1.43e-03
Peptide hormone metabolism 49 2.04e-01 0.105000 4.93e-01
Constitutive Signaling by Overexpressed ERBB2 11 5.47e-01 0.105000 7.62e-01
Cell Cycle 623 8.32e-06 0.105000 2.47e-04
G alpha (s) signalling events 145 2.98e-02 0.105000 1.66e-01
DNA Double-Strand Break Repair 135 3.60e-02 0.104000 1.84e-01
Regulation of Apoptosis 52 1.94e-01 0.104000 4.83e-01
SUMOylation of DNA damage response and repair proteins 77 1.15e-01 0.104000 3.65e-01
RNA Pol II CTD phosphorylation and interaction with CE 27 3.50e-01 -0.104000 6.36e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 3.50e-01 -0.104000 6.36e-01
Interleukin-12 signaling 44 2.33e-01 0.104000 5.27e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 4.72e-01 0.104000 7.13e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 80 1.09e-01 -0.104000 3.57e-01
FGFR1 mutant receptor activation 23 3.91e-01 0.103000 6.66e-01
PIP3 activates AKT signaling 241 5.74e-03 -0.103000 5.45e-02
Cell recruitment (pro-inflammatory response) 22 4.02e-01 0.103000 6.74e-01
Purinergic signaling in leishmaniasis infection 22 4.02e-01 0.103000 6.74e-01
Cell-cell junction organization 38 2.71e-01 -0.103000 5.67e-01
Initiation of Nuclear Envelope (NE) Reformation 19 4.37e-01 0.103000 6.96e-01
IRS-related events triggered by IGF1R 35 2.93e-01 -0.103000 5.80e-01
Signaling by high-kinase activity BRAF mutants 31 3.23e-01 -0.103000 6.11e-01
Nephrin family interactions 18 4.52e-01 -0.102000 6.99e-01
Signaling by WNT 255 4.86e-03 -0.102000 5.07e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 73 1.31e-01 0.102000 3.90e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 5.58e-01 -0.102000 7.70e-01
TNFs bind their physiological receptors 25 3.78e-01 -0.102000 6.55e-01
G beta:gamma signalling through PLC beta 17 4.68e-01 -0.102000 7.11e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 53 2.01e-01 0.102000 4.91e-01
G alpha (12/13) signalling events 68 1.48e-01 -0.101000 4.12e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 4.45e-01 -0.101000 6.98e-01
Regulation of PTEN mRNA translation 13 5.27e-01 0.101000 7.43e-01
IGF1R signaling cascade 36 2.93e-01 -0.101000 5.80e-01
Diseases of glycosylation 110 6.80e-02 -0.101000 2.74e-01
Bile acid and bile salt metabolism 28 3.57e-01 0.101000 6.39e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 3.68e-01 -0.100000 6.50e-01
Neutrophil degranulation 458 2.42e-04 -0.100000 4.80e-03
Apoptosis induced DNA fragmentation 10 5.84e-01 0.100000 7.84e-01
Cargo recognition for clathrin-mediated endocytosis 90 1.01e-01 -0.099900 3.44e-01
PI3K events in ERBB2 signaling 11 5.66e-01 -0.099800 7.74e-01
rRNA modification in the nucleus and cytosol 59 1.86e-01 -0.099600 4.76e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 1.26e-01 -0.099500 3.81e-01
MECP2 regulates neuronal receptors and channels 13 5.35e-01 -0.099300 7.51e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 4.54e-01 0.099200 7.00e-01
Downstream signaling of activated FGFR3 16 4.92e-01 0.099100 7.28e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 26 3.82e-01 -0.099000 6.56e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 4.43e-01 0.099000 6.98e-01
Synthesis of PE 12 5.53e-01 0.098900 7.68e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 3.75e-01 -0.098700 6.54e-01
Binding and Uptake of Ligands by Scavenger Receptors 92 1.02e-01 0.098700 3.44e-01
SCF(Skp2)-mediated degradation of p27/p21 60 1.86e-01 0.098700 4.76e-01
Homology Directed Repair 110 7.43e-02 0.098500 2.89e-01
Transcription of E2F targets under negative control by DREAM complex 19 4.58e-01 0.098400 7.02e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 5.24e-01 0.098400 7.41e-01
SUMOylation of intracellular receptors 27 3.77e-01 -0.098300 6.55e-01
Phase 0 - rapid depolarisation 23 4.15e-01 0.098300 6.82e-01
Metabolism of folate and pterines 17 4.83e-01 0.098200 7.22e-01
RUNX2 regulates bone development 24 4.08e-01 -0.097600 6.76e-01
DNA Damage Recognition in GG-NER 38 2.98e-01 -0.097600 5.86e-01
Post-chaperonin tubulin folding pathway 19 4.62e-01 -0.097500 7.07e-01
Role of LAT2/NTAL/LAB on calcium mobilization 74 1.47e-01 0.097500 4.10e-01
Diseases of metabolism 190 2.07e-02 -0.097300 1.27e-01
Signaling by FGFR 69 1.63e-01 -0.097100 4.40e-01
RHO GTPases activate PKNs 47 2.50e-01 -0.097000 5.41e-01
Interleukin-17 signaling 68 1.67e-01 -0.096800 4.46e-01
Nonhomologous End-Joining (NHEJ) 42 2.81e-01 0.096100 5.70e-01
mRNA 3’-end processing 56 2.17e-01 0.095300 5.08e-01
The NLRP3 inflammasome 15 5.23e-01 0.095200 7.41e-01
G1/S DNA Damage Checkpoints 66 1.82e-01 0.095100 4.67e-01
Signaling by VEGF 97 1.07e-01 -0.094700 3.54e-01
Activation of NMDA receptors and postsynaptic events 60 2.05e-01 -0.094600 4.93e-01
Early Phase of HIV Life Cycle 14 5.40e-01 0.094600 7.56e-01
VxPx cargo-targeting to cilium 19 4.76e-01 0.094500 7.16e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 1.91e-01 -0.094500 4.81e-01
Mitochondrial calcium ion transport 22 4.45e-01 -0.094100 6.98e-01
p53-Dependent G1 DNA Damage Response 64 1.94e-01 0.094000 4.83e-01
p53-Dependent G1/S DNA damage checkpoint 64 1.94e-01 0.094000 4.83e-01
Phase II - Conjugation of compounds 66 1.89e-01 0.093500 4.79e-01
HCMV Late Events 69 1.80e-01 -0.093400 4.66e-01
Rab regulation of trafficking 120 7.77e-02 -0.093200 2.99e-01
APC/C:Cdc20 mediated degradation of Securin 67 1.88e-01 0.093000 4.78e-01
M Phase 360 2.48e-03 0.092800 3.23e-02
APC-Cdc20 mediated degradation of Nek2A 26 4.14e-01 0.092600 6.82e-01
Uptake and actions of bacterial toxins 27 4.07e-01 -0.092200 6.76e-01
Signaling by Erythropoietin 24 4.35e-01 -0.092000 6.96e-01
NoRC negatively regulates rRNA expression 59 2.24e-01 -0.091600 5.16e-01
IKK complex recruitment mediated by RIP1 23 4.48e-01 0.091500 6.98e-01
Glucagon-type ligand receptors 20 4.80e-01 -0.091300 7.19e-01
Signaling by BMP 21 4.70e-01 0.091100 7.11e-01
ERK/MAPK targets 22 4.60e-01 -0.091000 7.05e-01
Assembly of the pre-replicative complex 67 1.98e-01 0.091000 4.87e-01
Removal of the Flap Intermediate 14 5.56e-01 0.090900 7.69e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 87 1.44e-01 -0.090700 4.04e-01
DNA Damage Bypass 47 2.83e-01 0.090500 5.70e-01
SUMOylation of RNA binding proteins 47 2.85e-01 0.090100 5.71e-01
Death Receptor Signalling 131 7.53e-02 -0.090000 2.91e-01
FRS-mediated FGFR3 signaling 11 6.06e-01 0.089900 7.96e-01
FRS-mediated FGFR1 signaling 14 5.60e-01 0.089900 7.71e-01
CTLA4 inhibitory signaling 21 4.77e-01 -0.089700 7.17e-01
Interleukin-15 signaling 14 5.62e-01 -0.089600 7.72e-01
WNT ligand biogenesis and trafficking 21 4.77e-01 0.089600 7.17e-01
Infectious disease 778 2.16e-05 -0.089500 5.79e-04
Ion transport by P-type ATPases 43 3.10e-01 -0.089400 6.00e-01
GABA receptor activation 36 3.54e-01 0.089300 6.38e-01
Peroxisomal lipid metabolism 27 4.23e-01 0.089100 6.85e-01
Negative epigenetic regulation of rRNA expression 62 2.26e-01 -0.088800 5.18e-01
Lysosphingolipid and LPA receptors 11 6.12e-01 -0.088400 7.98e-01
Metabolism 1771 6.38e-10 -0.088400 3.23e-08
Integration of energy metabolism 86 1.57e-01 -0.088300 4.31e-01
Signaling by Insulin receptor 59 2.41e-01 -0.088200 5.35e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 4.21e-01 -0.087900 6.83e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 5.08e-01 0.087700 7.35e-01
Post NMDA receptor activation events 50 2.85e-01 -0.087500 5.70e-01
Regulation of MECP2 expression and activity 28 4.24e-01 -0.087400 6.85e-01
Cytosolic sensors of pathogen-associated DNA 62 2.36e-01 -0.086900 5.29e-01
Signaling by TGF-beta Receptor Complex 72 2.05e-01 -0.086400 4.93e-01
Resolution of Abasic Sites (AP sites) 37 3.64e-01 -0.086300 6.48e-01
Miscellaneous transport and binding events 20 5.05e-01 -0.086100 7.33e-01
Formation of RNA Pol II elongation complex 57 2.66e-01 -0.085200 5.62e-01
RNA Polymerase II Transcription Elongation 57 2.66e-01 -0.085200 5.62e-01
GRB2 events in EGFR signaling 11 6.25e-01 -0.085100 8.07e-01
Butyrophilin (BTN) family interactions 10 6.42e-01 0.085000 8.17e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 184 4.68e-02 -0.085000 2.16e-01
VEGFA-VEGFR2 Pathway 90 1.65e-01 -0.084700 4.40e-01
Termination of translesion DNA synthesis 32 4.07e-01 0.084700 6.76e-01
Transcriptional regulation by small RNAs 63 2.46e-01 -0.084600 5.35e-01
Neuronal System 262 1.86e-02 -0.084500 1.18e-01
Post-translational protein phosphorylation 69 2.27e-01 -0.084200 5.18e-01
Mitochondrial biogenesis 89 1.71e-01 -0.084000 4.50e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 4.67e-01 -0.084000 7.11e-01
FCERI mediated MAPK activation 90 1.70e-01 0.083600 4.50e-01
MyD88 dependent cascade initiated on endosome 88 1.76e-01 -0.083400 4.60e-01
Cyclin E associated events during G1/S transition 83 1.89e-01 0.083300 4.79e-01
Diseases of programmed cell death 27 4.54e-01 -0.083300 7.00e-01
Hedgehog ligand biogenesis 59 2.68e-01 0.083300 5.64e-01
Frs2-mediated activation 11 6.32e-01 -0.083300 8.11e-01
Regulation of ornithine decarboxylase (ODC) 50 3.09e-01 0.083100 5.99e-01
Activation of gene expression by SREBF (SREBP) 42 3.52e-01 -0.083100 6.37e-01
Metabolism of polyamines 58 2.74e-01 0.083000 5.70e-01
HIV Transcription Initiation 45 3.37e-01 0.082800 6.25e-01
RNA Polymerase II HIV Promoter Escape 45 3.37e-01 0.082800 6.25e-01
RNA Polymerase II Promoter Escape 45 3.37e-01 0.082800 6.25e-01
RNA Polymerase II Transcription Initiation 45 3.37e-01 0.082800 6.25e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 3.37e-01 0.082800 6.25e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 3.37e-01 0.082800 6.25e-01
SHC1 events in EGFR signaling 12 6.22e-01 -0.082100 8.07e-01
Stabilization of p53 55 2.92e-01 0.082100 5.80e-01
Sema3A PAK dependent Axon repulsion 16 5.71e-01 -0.081700 7.77e-01
Disease 1354 4.44e-07 -0.081700 1.69e-05
Activation of kainate receptors upon glutamate binding 26 4.71e-01 -0.081700 7.11e-01
Sema4D in semaphorin signaling 22 5.08e-01 -0.081400 7.35e-01
Anchoring of the basal body to the plasma membrane 96 1.68e-01 0.081400 4.46e-01
Hemostasis 546 1.15e-03 -0.081400 1.89e-02
NOD1/2 Signaling Pathway 32 4.26e-01 0.081300 6.87e-01
Cilium Assembly 180 6.12e-02 0.080900 2.56e-01
Transcriptional activation of mitochondrial biogenesis 51 3.19e-01 -0.080700 6.08e-01
Aggrephagy 22 5.13e-01 -0.080500 7.37e-01
Advanced glycosylation endproduct receptor signaling 12 6.30e-01 -0.080300 8.11e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 3.79e-01 -0.080300 6.56e-01
Keratan sulfate/keratin metabolism 27 4.70e-01 -0.080200 7.11e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 3.22e-01 0.080200 6.10e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 6.07e-01 0.079500 7.96e-01
Acyl chain remodelling of PS 14 6.07e-01 0.079300 7.96e-01
Glutathione conjugation 26 4.85e-01 0.079100 7.23e-01
Budding and maturation of HIV virion 26 4.85e-01 -0.079100 7.23e-01
Beta-catenin independent WNT signaling 137 1.12e-01 -0.078600 3.61e-01
Platelet sensitization by LDL 16 5.87e-01 0.078400 7.85e-01
Ub-specific processing proteases 171 7.73e-02 0.078300 2.98e-01
MAP kinase activation 63 2.83e-01 -0.078100 5.70e-01
Deadenylation-dependent mRNA decay 53 3.27e-01 0.077800 6.18e-01
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 2.04e-01 -0.077800 4.93e-01
Opioid Signalling 75 2.45e-01 -0.077700 5.35e-01
Hh mutants abrogate ligand secretion 55 3.19e-01 0.077600 6.09e-01
mRNA decay by 3’ to 5’ exoribonuclease 16 5.91e-01 -0.077600 7.88e-01
Degradation of GLI1 by the proteasome 58 3.08e-01 0.077400 5.98e-01
Mitochondrial translation elongation 91 2.02e-01 -0.077300 4.93e-01
Protein localization 157 9.45e-02 -0.077300 3.33e-01
G alpha (i) signalling events 245 3.74e-02 -0.077200 1.88e-01
IRS-mediated signalling 34 4.36e-01 -0.077200 6.96e-01
Regulation of PLK1 Activity at G2/M Transition 86 2.16e-01 0.077100 5.08e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 5.82e-01 -0.077100 7.83e-01
Neurotransmitter receptors and postsynaptic signal transmission 127 1.34e-01 -0.077100 3.91e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.83e-01 0.077000 7.83e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.83e-01 0.077000 7.83e-01
G-protein activation 23 5.24e-01 0.076800 7.41e-01
Clathrin-mediated endocytosis 127 1.36e-01 -0.076600 3.92e-01
Rho GTPase cycle 125 1.40e-01 -0.076300 3.99e-01
Signaling by TGFB family members 91 2.10e-01 -0.076100 5.01e-01
Formation of TC-NER Pre-Incision Complex 53 3.39e-01 -0.075900 6.27e-01
Regulation of RAS by GAPs 67 2.83e-01 0.075900 5.70e-01
Interleukin-6 family signaling 19 5.67e-01 -0.075800 7.74e-01
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 54 3.37e-01 0.075500 6.25e-01
Interleukin receptor SHC signaling 23 5.32e-01 -0.075300 7.48e-01
mTORC1-mediated signalling 24 5.25e-01 -0.075000 7.42e-01
Striated Muscle Contraction 25 5.16e-01 -0.075000 7.39e-01
RHO GTPases Activate ROCKs 18 5.82e-01 0.074900 7.83e-01
RAS processing 19 5.74e-01 -0.074500 7.79e-01
RHO GTPases activate PAKs 20 5.65e-01 0.074400 7.73e-01
ADP signalling through P2Y purinoceptor 12 18 5.90e-01 0.073300 7.87e-01
FCERI mediated Ca+2 mobilization 89 2.33e-01 0.073200 5.27e-01
Transcriptional regulation of white adipocyte differentiation 77 2.67e-01 -0.073100 5.63e-01
SCF-beta-TrCP mediated degradation of Emi1 54 3.53e-01 0.073100 6.37e-01
CD28 dependent Vav1 pathway 12 6.61e-01 0.073100 8.30e-01
Ion channel transport 136 1.43e-01 -0.072700 4.04e-01
Fatty acyl-CoA biosynthesis 34 4.63e-01 0.072700 7.07e-01
Signal Transduction 1899 1.85e-07 -0.072200 8.10e-06
Acyl chain remodelling of PC 19 5.86e-01 0.072200 7.85e-01
Cyclin A:Cdk2-associated events at S phase entry 85 2.51e-01 0.072100 5.41e-01
Epigenetic regulation of gene expression 100 2.13e-01 -0.072000 5.05e-01
AURKA Activation by TPX2 71 2.95e-01 0.071900 5.81e-01
GPVI-mediated activation cascade 31 4.88e-01 -0.071900 7.24e-01
RNA Polymerase I Transcription Termination 27 5.19e-01 0.071700 7.39e-01
RIPK1-mediated regulated necrosis 29 5.04e-01 0.071700 7.33e-01
Regulated Necrosis 29 5.04e-01 0.071700 7.33e-01
Regulation of necroptotic cell death 29 5.04e-01 0.071700 7.33e-01
Sphingolipid metabolism 78 2.77e-01 -0.071200 5.70e-01
DNA strand elongation 32 4.86e-01 0.071200 7.23e-01
GRB2 events in ERBB2 signaling 11 6.83e-01 -0.071000 8.46e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 4.50e-01 -0.070900 6.98e-01
Signaling by RAS mutants 38 4.50e-01 -0.070900 6.98e-01
Signaling by moderate kinase activity BRAF mutants 38 4.50e-01 -0.070900 6.98e-01
Signaling downstream of RAS mutants 38 4.50e-01 -0.070900 6.98e-01
GABA synthesis, release, reuptake and degradation 13 6.59e-01 -0.070600 8.29e-01
Recognition of DNA damage by PCNA-containing replication complex 30 5.04e-01 0.070500 7.33e-01
Synthesis of PIPs at the plasma membrane 52 3.80e-01 -0.070400 6.56e-01
Transport of small molecules 563 4.43e-03 -0.070100 4.76e-02
UCH proteinases 87 2.59e-01 -0.070100 5.54e-01
Cell surface interactions at the vascular wall 174 1.11e-01 -0.070000 3.59e-01
Iron uptake and transport 52 3.84e-01 -0.069800 6.58e-01
SARS-CoV Infections 140 1.54e-01 -0.069800 4.26e-01
FCERI mediated NF-kB activation 138 1.57e-01 0.069700 4.31e-01
Beta-oxidation of very long chain fatty acids 10 7.03e-01 -0.069700 8.59e-01
PI-3K cascade:FGFR2 12 6.76e-01 0.069600 8.42e-01
Regulation of signaling by CBL 18 6.09e-01 -0.069600 7.96e-01
RNA Polymerase III Transcription Termination 23 5.64e-01 -0.069600 7.73e-01
FOXO-mediated transcription 59 3.57e-01 -0.069400 6.39e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation 49 4.01e-01 0.069300 6.74e-01
DAP12 interactions 39 4.56e-01 -0.069000 7.02e-01
Beta-catenin phosphorylation cascade 17 6.24e-01 -0.068600 8.07e-01
Sulfur amino acid metabolism 23 5.69e-01 -0.068500 7.76e-01
SLC-mediated transmembrane transport 180 1.13e-01 -0.068400 3.62e-01
G beta:gamma signalling through BTK 15 6.48e-01 0.068100 8.21e-01
Cyclin D associated events in G1 47 4.20e-01 0.068000 6.83e-01
G1 Phase 47 4.20e-01 0.068000 6.83e-01
Translesion synthesis by POLK 17 6.30e-01 0.067400 8.11e-01
Toll Like Receptor 9 (TLR9) Cascade 92 2.66e-01 -0.067100 5.62e-01
Carnitine metabolism 10 7.14e-01 -0.067100 8.65e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 51 4.09e-01 0.066800 6.76e-01
p53-Independent DNA Damage Response 51 4.09e-01 0.066800 6.76e-01
p53-Independent G1/S DNA damage checkpoint 51 4.09e-01 0.066800 6.76e-01
Insulin receptor recycling 21 5.98e-01 -0.066400 7.93e-01
IL-6-type cytokine receptor ligand interactions 13 6.79e-01 -0.066200 8.45e-01
Class I peroxisomal membrane protein import 20 6.09e-01 0.066000 7.96e-01
Alpha-protein kinase 1 signaling pathway 11 7.05e-01 -0.065900 8.61e-01
PKMTs methylate histone lysines 45 4.45e-01 -0.065800 6.98e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 6.39e-01 0.065600 8.16e-01
Unblocking of NMDA receptors, glutamate binding and activation 13 6.85e-01 -0.065100 8.47e-01
ER-Phagosome pathway 83 3.06e-01 0.064900 5.97e-01
Antigen processing-Cross presentation 98 2.67e-01 0.064800 5.63e-01
Neurotransmitter release cycle 37 4.97e-01 0.064600 7.32e-01
Energy dependent regulation of mTOR by LKB1-AMPK 28 5.55e-01 0.064500 7.69e-01
Listeria monocytogenes entry into host cells 17 6.46e-01 -0.064400 8.20e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 5.85e-01 0.064400 7.85e-01
Interaction between L1 and Ankyrins 22 6.02e-01 0.064300 7.96e-01
Signaling by RAF1 mutants 34 5.18e-01 -0.064100 7.39e-01
IRF3-mediated induction of type I IFN 12 7.02e-01 -0.063900 8.59e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 5.88e-01 -0.063800 7.85e-01
Degradation of GLI2 by the proteasome 57 4.06e-01 0.063600 6.76e-01
RNA Polymerase II Transcription Termination 65 3.76e-01 0.063400 6.55e-01
SHC1 events in ERBB2 signaling 17 6.51e-01 -0.063400 8.22e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 5.42e-01 -0.063300 7.58e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 3.81e-01 0.063300 6.56e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 3.17e-01 0.063200 6.07e-01
Vif-mediated degradation of APOBEC3G 53 4.28e-01 0.062900 6.89e-01
Translesion synthesis by POLI 17 6.54e-01 0.062900 8.24e-01
Signaling by Activin 10 7.31e-01 -0.062700 8.76e-01
Degradation of AXIN 54 4.27e-01 0.062500 6.88e-01
activated TAK1 mediates p38 MAPK activation 19 6.38e-01 -0.062300 8.16e-01
Signaling by Interleukins 388 3.80e-02 -0.061400 1.89e-01
Interleukin-10 signaling 37 5.19e-01 -0.061200 7.39e-01
MAPK6/MAPK4 signaling 83 3.36e-01 0.061100 6.25e-01
Mismatch Repair 15 6.83e-01 0.060900 8.46e-01
Signaling by ERBB4 44 4.87e-01 -0.060500 7.23e-01
COPII-mediated vesicle transport 65 3.99e-01 0.060400 6.73e-01
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.17e-01 -0.060300 6.07e-01
Toll Like Receptor 2 (TLR2) Cascade 92 3.17e-01 -0.060300 6.07e-01
Toll Like Receptor TLR1:TLR2 Cascade 92 3.17e-01 -0.060300 6.07e-01
Toll Like Receptor TLR6:TLR2 Cascade 92 3.17e-01 -0.060300 6.07e-01
Defective CFTR causes cystic fibrosis 60 4.20e-01 0.060200 6.83e-01
COPI-dependent Golgi-to-ER retrograde traffic 78 3.58e-01 0.060200 6.41e-01
Dual Incision in GG-NER 41 5.05e-01 0.060200 7.33e-01
TRAF6 mediated NF-kB activation 23 6.18e-01 -0.060000 8.05e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 7.31e-01 0.059900 8.76e-01
Negative regulation of MAPK pathway 42 5.02e-01 -0.059900 7.33e-01
ROS and RNS production in phagocytes 31 5.65e-01 -0.059700 7.73e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 5.98e-01 -0.059700 7.93e-01
RHO GTPases activate KTN1 11 7.35e-01 0.058900 8.79e-01
Signaling by NTRK3 (TRKC) 16 6.83e-01 -0.058900 8.46e-01
Regulated proteolysis of p75NTR 11 7.36e-01 -0.058800 8.79e-01
ER to Golgi Anterograde Transport 129 2.49e-01 0.058800 5.41e-01
Folding of actin by CCT/TriC 10 7.48e-01 0.058700 8.90e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 5.87e-01 -0.058300 7.85e-01
Metalloprotease DUBs 21 6.44e-01 0.058200 8.19e-01
Platelet homeostasis 69 4.03e-01 -0.058200 6.74e-01
Role of phospholipids in phagocytosis 88 3.45e-01 0.058200 6.31e-01
G-protein beta:gamma signalling 29 5.88e-01 -0.058100 7.85e-01
Golgi-to-ER retrograde transport 111 2.90e-01 0.058100 5.80e-01
COPI-mediated anterograde transport 78 3.76e-01 0.058000 6.55e-01
FLT3 Signaling 245 1.19e-01 -0.057900 3.71e-01
Signaling by FGFR3 31 5.77e-01 -0.057900 7.81e-01
Mitochondrial tRNA aminoacylation 21 6.49e-01 0.057300 8.21e-01
Class I MHC mediated antigen processing & presentation 349 6.61e-02 0.057300 2.68e-01
NOTCH2 intracellular domain regulates transcription 11 7.43e-01 -0.057100 8.85e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 6.22e-01 -0.056900 8.07e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 6.23e-01 0.056700 8.07e-01
Costimulation by the CD28 family 74 4.00e-01 -0.056600 6.73e-01
Loss of Nlp from mitotic centrosomes 68 4.20e-01 0.056600 6.83e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 4.20e-01 0.056600 6.83e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 3.70e-01 0.056500 6.52e-01
GPCR ligand binding 237 1.34e-01 -0.056500 3.91e-01
Metabolism of nucleotides 86 3.71e-01 -0.055800 6.52e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 6.92e-01 0.055600 8.53e-01
Vpu mediated degradation of CD4 51 4.97e-01 0.055000 7.32e-01
PTEN Regulation 139 2.63e-01 -0.055000 5.62e-01
Zinc transporters 14 7.22e-01 0.054900 8.73e-01
Transmission across Chemical Synapses 173 2.13e-01 -0.054900 5.05e-01
Mitochondrial translation initiation 91 3.66e-01 -0.054900 6.50e-01
Glucose metabolism 83 3.88e-01 -0.054800 6.64e-01
Formation of tubulin folding intermediates by CCT/TriC 22 6.58e-01 -0.054600 8.28e-01
tRNA modification in the nucleus and cytosol 43 5.36e-01 0.054600 7.51e-01
Metabolism of RNA 688 1.52e-02 -0.054300 1.01e-01
VEGFR2 mediated vascular permeability 26 6.32e-01 -0.054300 8.11e-01
Regulation of TP53 Degradation 35 5.80e-01 -0.054000 7.83e-01
Regulation of PTEN stability and activity 67 4.45e-01 0.054000 6.98e-01
SUMOylation of chromatin organization proteins 57 4.86e-01 0.053400 7.23e-01
Mitochondrial iron-sulfur cluster biogenesis 13 7.40e-01 0.053200 8.82e-01
Mitochondrial translation termination 91 3.82e-01 -0.053000 6.56e-01
COPI-independent Golgi-to-ER retrograde traffic 33 6.00e-01 0.052700 7.94e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 6.11e-01 -0.052700 7.98e-01
PI-3K cascade:FGFR4 10 7.73e-01 -0.052700 9.02e-01
Stimuli-sensing channels 75 4.30e-01 -0.052700 6.91e-01
NIK–>noncanonical NF-kB signaling 58 4.89e-01 0.052500 7.24e-01
FCGR3A-mediated IL10 synthesis 99 3.68e-01 0.052300 6.50e-01
Unwinding of DNA 12 7.54e-01 -0.052200 8.92e-01
Signaling by FGFR1 38 5.77e-01 -0.052200 7.81e-01
Intra-Golgi traffic 43 5.54e-01 -0.052200 7.68e-01
Translesion Synthesis by POLH 18 7.03e-01 -0.051900 8.59e-01
Amine ligand-binding receptors 10 7.76e-01 0.051900 9.05e-01
Activation of BAD and translocation to mitochondria 15 7.31e-01 -0.051200 8.76e-01
Negative regulators of DDX58/IFIH1 signaling 34 6.06e-01 0.051100 7.96e-01
Regulation of TNFR1 signaling 34 6.07e-01 -0.051000 7.96e-01
HIV Life Cycle 144 2.91e-01 0.050900 5.80e-01
Triglyceride catabolism 16 7.26e-01 -0.050700 8.73e-01
RAF/MAP kinase cascade 231 1.85e-01 -0.050600 4.75e-01
Negative regulation of NOTCH4 signaling 54 5.21e-01 0.050500 7.39e-01
NCAM1 interactions 23 6.75e-01 0.050500 8.42e-01
Activation of GABAB receptors 31 6.29e-01 0.050200 8.11e-01
GABA B receptor activation 31 6.29e-01 0.050200 8.11e-01
RA biosynthesis pathway 13 7.54e-01 -0.050200 8.92e-01
Signaling by Retinoic Acid 32 6.25e-01 -0.050000 8.07e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 6.43e-01 -0.049800 8.18e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 4.49e-01 -0.049500 6.98e-01
Intraflagellar transport 39 5.94e-01 0.049400 7.90e-01
Dectin-2 family 19 7.10e-01 0.049200 8.65e-01
Association of TriC/CCT with target proteins during biosynthesis 37 6.05e-01 -0.049100 7.96e-01
Detoxification of Reactive Oxygen Species 32 6.31e-01 -0.049100 8.11e-01
Transcriptional regulation of pluripotent stem cells 21 6.97e-01 0.049000 8.57e-01
RAB geranylgeranylation 62 5.05e-01 0.049000 7.33e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 5.64e-01 0.048600 7.73e-01
Vitamin B5 (pantothenate) metabolism 17 7.29e-01 0.048600 8.76e-01
Peptide ligand-binding receptors 97 4.09e-01 -0.048500 6.76e-01
Signal amplification 28 6.57e-01 0.048400 8.28e-01
Class A/1 (Rhodopsin-like receptors) 170 2.79e-01 -0.048200 5.70e-01
Dual incision in TC-NER 65 5.03e-01 -0.048000 7.33e-01
Metabolism of steroids 119 3.68e-01 0.047800 6.50e-01
EPHA-mediated growth cone collapse 13 7.66e-01 0.047600 8.99e-01
Defects in vitamin and cofactor metabolism 21 7.06e-01 0.047600 8.61e-01
PI-3K cascade:FGFR1 12 7.76e-01 0.047500 9.05e-01
Signal transduction by L1 20 7.14e-01 -0.047400 8.65e-01
Regulation of actin dynamics for phagocytic cup formation 123 3.65e-01 0.047300 6.49e-01
Metabolic disorders of biological oxidation enzymes 24 6.88e-01 -0.047300 8.50e-01
Diseases of signal transduction by growth factor receptors and second messengers 342 1.35e-01 -0.047000 3.92e-01
MAPK1/MAPK3 signaling 236 2.14e-01 -0.047000 5.06e-01
Processive synthesis on the lagging strand 15 7.53e-01 0.047000 8.92e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 6.86e-01 -0.046700 8.48e-01
Signaling by the B Cell Receptor (BCR) 163 3.07e-01 0.046400 5.97e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 6.61e-01 0.046300 8.30e-01
Selective autophagy 59 5.44e-01 -0.045600 7.60e-01
Muscle contraction 138 3.56e-01 -0.045600 6.39e-01
GLI3 is processed to GLI3R by the proteasome 58 5.50e-01 0.045400 7.66e-01
Acyl chain remodelling of PE 20 7.26e-01 0.045300 8.73e-01
RNA Polymerase I Transcription Initiation 44 6.04e-01 -0.045200 7.96e-01
Transferrin endocytosis and recycling 26 6.91e-01 -0.045000 8.53e-01
Fc epsilon receptor (FCERI) signaling 191 2.84e-01 0.044900 5.70e-01
Late Phase of HIV Life Cycle 131 3.75e-01 0.044900 6.54e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 8.06e-01 -0.044800 9.23e-01
Downstream signaling of activated FGFR4 17 7.50e-01 0.044600 8.90e-01
Signaling by GPCR 547 7.60e-02 -0.044300 2.94e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 7.52e-01 0.044300 8.91e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 5.14e-01 0.044200 7.37e-01
Antigen processing: Ubiquitination & Proteasome degradation 288 1.98e-01 0.044100 4.87e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 6.49e-01 0.043800 8.21e-01
Calnexin/calreticulin cycle 26 7.02e-01 -0.043300 8.59e-01
Innate Immune System 968 2.26e-02 -0.043300 1.36e-01
HCMV Infection 96 4.64e-01 -0.043200 7.07e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 83 4.96e-01 -0.043200 7.32e-01
Centrosome maturation 80 5.06e-01 0.043000 7.33e-01
Recruitment of mitotic centrosome proteins and complexes 80 5.06e-01 0.043000 7.33e-01
Gene Silencing by RNA 88 4.87e-01 -0.042900 7.23e-01
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 7.97e-01 -0.042800 9.17e-01
E3 ubiquitin ligases ubiquitinate target proteins 52 5.95e-01 -0.042600 7.91e-01
Regulation of TP53 Activity 153 3.64e-01 0.042500 6.48e-01
Regulation of HSF1-mediated heat shock response 79 5.14e-01 0.042500 7.37e-01
Amino acids regulate mTORC1 50 6.04e-01 -0.042400 7.96e-01
Autodegradation of the E3 ubiquitin ligase COP1 50 6.04e-01 0.042400 7.96e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 65 5.59e-01 0.041900 7.70e-01
RNA Polymerase III Transcription Initiation 36 6.64e-01 -0.041900 8.32e-01
Processing of Capped Intron-Containing Pre-mRNA 238 2.68e-01 0.041700 5.64e-01
Signaling by SCF-KIT 40 6.50e-01 -0.041500 8.21e-01
p130Cas linkage to MAPK signaling for integrins 11 8.12e-01 -0.041500 9.25e-01
Signalling to RAS 18 7.62e-01 0.041200 8.97e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 7.90e-01 0.041100 9.14e-01
Nuclear Envelope (NE) Reassembly 69 5.55e-01 0.041100 7.69e-01
Glutathione synthesis and recycling 10 8.22e-01 -0.041000 9.31e-01
Interleukin-35 Signalling 12 8.07e-01 0.040800 9.23e-01
ABC transporters in lipid homeostasis 14 7.92e-01 0.040600 9.15e-01
Nucleobase catabolism 28 7.12e-01 -0.040400 8.65e-01
Regulation of TP53 Expression and Degradation 36 6.77e-01 -0.040200 8.42e-01
Macroautophagy 111 4.66e-01 -0.040100 7.09e-01
Glutamate Neurotransmitter Release Cycle 20 7.57e-01 0.039900 8.93e-01
Downstream signal transduction 27 7.23e-01 0.039500 8.73e-01
Toll Like Receptor 3 (TLR3) Cascade 92 5.13e-01 -0.039500 7.37e-01
Potential therapeutics for SARS 78 5.48e-01 -0.039300 7.64e-01
Dectin-1 mediated noncanonical NF-kB signaling 60 5.99e-01 0.039300 7.93e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 7.02e-01 -0.039100 8.59e-01
DNA Repair 289 2.58e-01 0.038700 5.53e-01
Deubiquitination 242 3.01e-01 0.038600 5.90e-01
Autophagy 125 4.64e-01 -0.038000 7.07e-01
Downstream signaling events of B Cell Receptor (BCR) 80 5.57e-01 0.037900 7.70e-01
O-linked glycosylation of mucins 47 6.53e-01 -0.037900 8.24e-01
Leishmania infection 246 3.06e-01 -0.037900 5.97e-01
Regulation of insulin secretion 60 6.14e-01 -0.037700 8.00e-01
Chaperonin-mediated protein folding 84 5.52e-01 -0.037500 7.68e-01
CLEC7A (Dectin-1) induces NFAT activation 11 8.29e-01 -0.037500 9.32e-01
Signaling by KIT in disease 20 7.73e-01 0.037300 9.02e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 7.73e-01 0.037300 9.02e-01
Regulation of IFNA signaling 12 8.24e-01 0.037200 9.31e-01
GPCR downstream signalling 501 1.54e-01 -0.037200 4.26e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 7.49e-01 0.036900 8.90e-01
Interleukin-2 family signaling 38 6.97e-01 -0.036500 8.57e-01
Receptor Mediated Mitophagy 11 8.34e-01 0.036400 9.32e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 7.89e-01 -0.036400 9.14e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 7.89e-01 -0.036400 9.14e-01
Peroxisomal protein import 57 6.38e-01 0.036100 8.16e-01
Signaling by NTRK2 (TRKB) 20 7.82e-01 0.035700 9.10e-01
SUMO E3 ligases SUMOylate target proteins 161 4.35e-01 -0.035700 6.96e-01
ADP signalling through P2Y purinoceptor 1 21 7.79e-01 0.035400 9.07e-01
Apoptotic execution phase 45 6.82e-01 0.035400 8.46e-01
Programmed Cell Death 180 4.13e-01 0.035400 6.82e-01
MAPK family signaling cascades 270 3.20e-01 -0.035200 6.09e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 88 5.71e-01 0.034900 7.77e-01
Signaling by ERBB2 in Cancer 21 7.86e-01 0.034200 9.13e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 7.72e-01 0.034200 9.02e-01
Protein folding 90 5.75e-01 -0.034200 7.79e-01
Metabolism of proteins 1721 1.86e-02 -0.034100 1.18e-01
Tie2 Signaling 16 8.14e-01 0.033900 9.27e-01
Toll Like Receptor 4 (TLR4) Cascade 121 5.20e-01 -0.033900 7.39e-01
Transport of bile salts and organic acids, metal ions and amine compounds 55 6.64e-01 -0.033900 8.32e-01
FCGR3A-mediated phagocytosis 121 5.21e-01 0.033800 7.39e-01
Leishmania phagocytosis 121 5.21e-01 0.033800 7.39e-01
Parasite infection 121 5.21e-01 0.033800 7.39e-01
Phospholipid metabolism 184 4.36e-01 -0.033300 6.96e-01
Mitochondrial translation 97 5.74e-01 -0.033100 7.79e-01
TNFR1-induced proapoptotic signaling 12 8.44e-01 0.032800 9.36e-01
Regulation of RUNX1 Expression and Activity 18 8.10e-01 -0.032700 9.24e-01
Chromosome Maintenance 105 5.65e-01 -0.032500 7.73e-01
Adherens junctions interactions 17 8.17e-01 -0.032400 9.27e-01
mRNA Capping 29 7.65e-01 -0.032000 8.99e-01
DARPP-32 events 22 7.97e-01 -0.031700 9.17e-01
Glycerophospholipid biosynthesis 106 5.74e-01 -0.031600 7.79e-01
Acyl chain remodelling of PI 10 8.63e-01 -0.031600 9.52e-01
Signaling by ERBB2 KD Mutants 20 8.07e-01 0.031500 9.23e-01
Diseases associated with the TLR signaling cascade 23 7.95e-01 0.031300 9.16e-01
Diseases of Immune System 23 7.95e-01 0.031300 9.16e-01
ABC-family proteins mediated transport 94 6.08e-01 0.030600 7.96e-01
Recruitment of NuMA to mitotic centrosomes 79 6.40e-01 0.030500 8.16e-01
Triglyceride metabolism 25 7.96e-01 0.029900 9.17e-01
Cytosolic sulfonation of small molecules 18 8.28e-01 -0.029500 9.32e-01
L1CAM interactions 85 6.38e-01 -0.029500 8.16e-01
HIV Infection 225 4.48e-01 0.029400 6.98e-01
Apoptosis 168 5.11e-01 0.029400 7.37e-01
Oncogenic MAPK signaling 73 6.64e-01 0.029400 8.32e-01
MyD88-independent TLR4 cascade 96 6.25e-01 -0.028900 8.07e-01
TRIF(TICAM1)-mediated TLR4 signaling 96 6.25e-01 -0.028900 8.07e-01
Meiotic recombination 38 7.59e-01 -0.028800 8.94e-01
Surfactant metabolism 22 8.15e-01 0.028700 9.27e-01
trans-Golgi Network Vesicle Budding 69 6.80e-01 -0.028700 8.45e-01
Diseases of DNA repair 10 8.75e-01 0.028700 9.61e-01
Ubiquitin-dependent degradation of Cyclin D 51 7.26e-01 0.028400 8.73e-01
TNF signaling 43 7.48e-01 -0.028300 8.90e-01
Signaling by FGFR in disease 50 7.32e-01 0.028000 8.77e-01
Viral Messenger RNA Synthesis 44 7.48e-01 0.028000 8.90e-01
Interleukin-6 signaling 10 8.79e-01 -0.027800 9.62e-01
RNA Polymerase II Pre-transcription Events 78 6.71e-01 0.027800 8.39e-01
Metabolism of steroid hormones 20 8.30e-01 0.027700 9.32e-01
Pyruvate metabolism 28 8.04e-01 0.027100 9.22e-01
TRP channels 19 8.39e-01 0.027000 9.33e-01
Myogenesis 21 8.32e-01 0.026800 9.32e-01
Biological oxidations 136 5.93e-01 -0.026500 7.90e-01
Metabolism of vitamins and cofactors 158 5.66e-01 -0.026500 7.73e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.34e-01 0.026500 9.32e-01
Signaling by MET 61 7.21e-01 -0.026400 8.72e-01
Organelle biogenesis and maintenance 269 4.57e-01 0.026300 7.02e-01
Protein ubiquitination 72 7.02e-01 -0.026100 8.59e-01
Glycolysis 66 7.14e-01 -0.026100 8.65e-01
Transcriptional regulation by RUNX2 102 6.49e-01 0.026100 8.21e-01
RHO GTPases Activate WASPs and WAVEs 35 7.90e-01 -0.026000 9.14e-01
Fatty acid metabolism 153 5.82e-01 -0.025800 7.83e-01
Transcription of the HIV genome 67 7.18e-01 0.025500 8.69e-01
Removal of the Flap Intermediate from the C-strand 17 8.57e-01 0.025200 9.48e-01
Immune System 1896 7.16e-02 -0.025000 2.83e-01
The canonical retinoid cycle in rods (twilight vision) 10 8.92e-01 -0.024800 9.63e-01
Interconversion of nucleotide di- and triphosphates 27 8.24e-01 0.024700 9.31e-01
Scavenging by Class A Receptors 12 8.83e-01 0.024500 9.63e-01
RAB GEFs exchange GTP for GDP on RABs 87 6.95e-01 -0.024300 8.56e-01
Signaling by Rho GTPases 365 4.36e-01 -0.023700 6.96e-01
Signaling by FGFR2 in disease 32 8.17e-01 -0.023600 9.27e-01
Degradation of DVL 55 7.62e-01 0.023600 8.97e-01
Eicosanoid ligand-binding receptors 13 8.83e-01 -0.023500 9.63e-01
Aflatoxin activation and detoxification 15 8.75e-01 -0.023500 9.61e-01
Hedgehog ‘on’ state 76 7.25e-01 0.023300 8.73e-01
Synthesis of PIPs at the Golgi membrane 16 8.72e-01 0.023200 9.61e-01
Nucleotide Excision Repair 110 6.76e-01 -0.023100 8.42e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 16 8.74e-01 -0.022900 9.61e-01
Regulation of RUNX3 expression and activity 55 7.71e-01 0.022700 9.02e-01
PI Metabolism 79 7.28e-01 -0.022600 8.76e-01
Retrograde transport at the Trans-Golgi-Network 49 7.86e-01 0.022400 9.13e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 7.63e-01 0.022000 8.97e-01
Metabolism of amine-derived hormones 10 9.05e-01 -0.021700 9.65e-01
Purine salvage 12 8.99e-01 0.021200 9.63e-01
Anti-inflammatory response favouring Leishmania parasite infection 170 6.33e-01 -0.021200 8.11e-01
Leishmania parasite growth and survival 170 6.33e-01 -0.021200 8.11e-01
STING mediated induction of host immune responses 15 8.88e-01 0.021000 9.63e-01
Transcriptional Regulation by VENTX 38 8.24e-01 0.020800 9.31e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 8.16e-01 -0.020500 9.27e-01
Telomere C-strand (Lagging Strand) Synthesis 34 8.43e-01 0.019700 9.36e-01
Diseases associated with glycosylation precursor biosynthesis 18 8.86e-01 0.019500 9.63e-01
Generic Transcription Pathway 1087 2.80e-01 -0.019400 5.70e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 8.36e-01 0.019400 9.33e-01
AMER1 mutants destabilize the destruction complex 14 9.02e-01 -0.019100 9.63e-01
APC truncation mutants have impaired AXIN binding 14 9.02e-01 -0.019100 9.63e-01
AXIN missense mutants destabilize the destruction complex 14 9.02e-01 -0.019100 9.63e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 9.02e-01 -0.019100 9.63e-01
Truncations of AMER1 destabilize the destruction complex 14 9.02e-01 -0.019100 9.63e-01
truncated APC mutants destabilize the destruction complex 14 9.02e-01 -0.019100 9.63e-01
NCAM signaling for neurite out-growth 43 8.29e-01 0.019000 9.32e-01
Signalling to ERKs 31 8.55e-01 0.018900 9.47e-01
Asymmetric localization of PCP proteins 61 7.99e-01 -0.018800 9.18e-01
CD209 (DC-SIGN) signaling 20 8.85e-01 -0.018600 9.63e-01
mRNA Splicing - Major Pathway 179 6.67e-01 -0.018600 8.35e-01
TP53 Regulates Transcription of Cell Death Genes 43 8.34e-01 0.018500 9.32e-01
tRNA processing 136 7.10e-01 -0.018400 8.65e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 9.09e-01 0.018400 9.66e-01
Thromboxane signalling through TP receptor 20 8.89e-01 -0.018100 9.63e-01
Downstream TCR signaling 101 7.56e-01 0.017900 8.92e-01
Negative regulation of MET activity 18 8.96e-01 -0.017800 9.63e-01
Metabolism of lipids 624 4.49e-01 -0.017800 6.98e-01
Growth hormone receptor signaling 20 8.91e-01 -0.017700 9.63e-01
RNA Polymerase III Abortive And Retractive Initiation 41 8.45e-01 -0.017700 9.36e-01
RNA Polymerase III Transcription 41 8.45e-01 -0.017700 9.36e-01
SUMOylation 167 6.95e-01 -0.017600 8.56e-01
Activation of NF-kappaB in B cells 66 8.07e-01 0.017400 9.23e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 9.08e-01 -0.017200 9.66e-01
SHC-mediated cascade:FGFR4 10 9.26e-01 0.016900 9.76e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 9.13e-01 -0.016900 9.68e-01
SLC transporter disorders 76 8.00e-01 -0.016800 9.19e-01
Erythropoietin activates RAS 13 9.17e-01 0.016700 9.71e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 8.91e-01 0.016500 9.63e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 8.40e-01 0.016200 9.34e-01
TNFR2 non-canonical NF-kB pathway 96 7.84e-01 0.016200 9.11e-01
MET promotes cell motility 26 8.86e-01 0.016200 9.63e-01
Ca2+ pathway 57 8.34e-01 -0.016000 9.32e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 9.27e-01 -0.015900 9.76e-01
C-type lectin receptors (CLRs) 130 7.56e-01 0.015800 8.92e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 9.08e-01 -0.015800 9.66e-01
Membrane Trafficking 559 5.27e-01 -0.015600 7.43e-01
Synthesis of PA 32 8.79e-01 0.015600 9.62e-01
Metal ion SLC transporters 21 9.07e-01 0.014700 9.66e-01
Translesion synthesis by REV1 16 9.19e-01 0.014600 9.72e-01
Reproduction 81 8.22e-01 -0.014400 9.31e-01
Signaling by ERBB2 TMD/JMD mutants 17 9.18e-01 -0.014400 9.72e-01
DAP12 signaling 28 8.95e-01 0.014300 9.63e-01
Dissolution of Fibrin Clot 12 9.32e-01 0.014200 9.78e-01
Mitotic Prophase 98 8.09e-01 0.014200 9.23e-01
Interleukin-1 signaling 98 8.09e-01 -0.014100 9.23e-01
Sialic acid metabolism 28 8.97e-01 0.014100 9.63e-01
Transport to the Golgi and subsequent modification 155 7.70e-01 0.013600 9.02e-01
Telomere Extension By Telomerase 23 9.10e-01 -0.013600 9.67e-01
Unfolded Protein Response (UPR) 88 8.27e-01 0.013500 9.32e-01
FRS-mediated FGFR4 signaling 12 9.36e-01 0.013500 9.78e-01
Signaling by NOTCH4 79 8.37e-01 -0.013400 9.33e-01
Interleukin-37 signaling 19 9.20e-01 -0.013400 9.72e-01
Signaling by PDGF 44 8.79e-01 0.013300 9.62e-01
Ovarian tumor domain proteases 37 8.89e-01 0.013300 9.63e-01
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 9.43e-01 0.013200 9.78e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 9.27e-01 0.013200 9.76e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 8.96e-01 -0.012600 9.63e-01
Generation of second messenger molecules 38 8.94e-01 -0.012500 9.63e-01
RHO GTPase Effectors 249 7.36e-01 0.012400 8.79e-01
Purine ribonucleoside monophosphate biosynthesis 10 9.47e-01 0.012200 9.78e-01
TNFR1-induced NFkappaB signaling pathway 25 9.17e-01 0.012000 9.71e-01
Intrinsic Pathway for Apoptosis 53 8.81e-01 -0.011900 9.63e-01
PPARA activates gene expression 104 8.35e-01 0.011800 9.32e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 9.02e-01 -0.011800 9.63e-01
TCR signaling 122 8.25e-01 0.011600 9.31e-01
Cellular response to heat stress 93 8.47e-01 -0.011600 9.39e-01
Sphingolipid de novo biosynthesis 42 8.99e-01 0.011300 9.63e-01
Potassium Channels 66 8.77e-01 0.011000 9.62e-01
Methylation 12 9.48e-01 0.010800 9.78e-01
Interleukin-1 family signaling 125 8.39e-01 -0.010600 9.33e-01
Misspliced GSK3beta mutants stabilize beta-catenin 15 9.44e-01 0.010400 9.78e-01
S33 mutants of beta-catenin aren’t phosphorylated 15 9.44e-01 0.010400 9.78e-01
S37 mutants of beta-catenin aren’t phosphorylated 15 9.44e-01 0.010400 9.78e-01
S45 mutants of beta-catenin aren’t phosphorylated 15 9.44e-01 0.010400 9.78e-01
T41 mutants of beta-catenin aren’t phosphorylated 15 9.44e-01 0.010400 9.78e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 9.44e-01 0.010400 9.78e-01
Nucleotide-like (purinergic) receptors 13 9.48e-01 0.010300 9.78e-01
Toll-like Receptor Cascades 143 8.31e-01 -0.010300 9.32e-01
Prolonged ERK activation events 13 9.49e-01 -0.010200 9.78e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 9.42e-01 0.010200 9.78e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 8.31e-01 0.010200 9.32e-01
Kinesins 39 9.13e-01 -0.010100 9.68e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA 54 8.99e-01 0.010000 9.63e-01
Telomere C-strand synthesis initiation 13 9.51e-01 0.009860 9.78e-01
MHC class II antigen presentation 101 8.73e-01 0.009230 9.61e-01
Processing of SMDT1 15 9.51e-01 -0.009120 9.78e-01
Processive synthesis on the C-strand of the telomere 19 9.46e-01 0.009020 9.78e-01
Ras activation upon Ca2+ influx through NMDA receptor 16 9.50e-01 -0.009000 9.78e-01
Citric acid cycle (TCA cycle) 22 9.44e-01 0.008700 9.78e-01
Translocation of ZAP-70 to Immunological synapse 24 9.42e-01 -0.008600 9.78e-01
TP53 Regulates Metabolic Genes 86 8.91e-01 -0.008580 9.63e-01
Disorders of transmembrane transporters 147 8.62e-01 -0.008300 9.52e-01
Endogenous sterols 16 9.55e-01 -0.008090 9.79e-01
Diseases associated with N-glycosylation of proteins 17 9.54e-01 0.008000 9.79e-01
Apoptotic cleavage of cellular proteins 34 9.40e-01 0.007470 9.78e-01
Hedgehog ‘off’ state 93 9.02e-01 -0.007350 9.63e-01
Depolymerisation of the Nuclear Lamina 15 9.61e-01 -0.007250 9.79e-01
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 9.28e-01 0.007030 9.76e-01
Netrin-1 signaling 40 9.40e-01 0.006930 9.78e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.50e-01 -0.006830 9.78e-01
Factors involved in megakaryocyte development and platelet production 116 8.99e-01 -0.006800 9.63e-01
Lysine catabolism 11 9.69e-01 -0.006740 9.83e-01
Cellular response to hypoxia 72 9.22e-01 0.006650 9.73e-01
PD-1 signaling 28 9.53e-01 0.006470 9.78e-01
Signaling by BRAF and RAF fusions 57 9.35e-01 -0.006270 9.78e-01
Degradation of beta-catenin by the destruction complex 84 9.22e-01 -0.006210 9.73e-01
Phosphorylation of CD3 and TCR zeta chains 27 9.56e-01 -0.006160 9.79e-01
The phototransduction cascade 26 9.57e-01 0.006090 9.79e-01
Transport of vitamins, nucleosides, and related molecules 33 9.52e-01 -0.006040 9.78e-01
Gene expression (Transcription) 1334 7.12e-01 0.006020 8.65e-01
p38MAPK events 13 9.70e-01 0.005930 9.83e-01
Asparagine N-linked glycosylation 269 8.68e-01 0.005870 9.57e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 9.50e-01 0.005750 9.78e-01
Nucleosome assembly 40 9.50e-01 0.005750 9.78e-01
Transcriptional regulation by RUNX3 90 9.29e-01 -0.005420 9.76e-01
mRNA Splicing 187 9.01e-01 -0.005290 9.63e-01
Fanconi Anemia Pathway 36 9.59e-01 -0.004980 9.79e-01
Cytochrome P450 - arranged by substrate type 36 9.59e-01 0.004900 9.79e-01
Prostacyclin signalling through prostacyclin receptor 16 9.74e-01 0.004630 9.84e-01
Post-translational protein modification 1196 7.92e-01 -0.004520 9.15e-01
Nicotinate metabolism 26 9.68e-01 -0.004510 9.83e-01
MTOR signalling 40 9.61e-01 0.004410 9.79e-01
Transcriptional Regulation by TP53 352 8.88e-01 0.004370 9.63e-01
Polymerase switching on the C-strand of the telomere 26 9.71e-01 -0.004080 9.83e-01
Regulation of lipid metabolism by PPARalpha 106 9.45e-01 0.003910 9.78e-01
Cytokine Signaling in Immune system 738 8.58e-01 0.003860 9.48e-01
Intra-Golgi and retrograde Golgi-to-ER traffic 179 9.36e-01 0.003490 9.78e-01
Meiosis 68 9.62e-01 0.003310 9.80e-01
ER Quality Control Compartment (ERQC) 21 9.81e-01 -0.003070 9.89e-01
Protein methylation 15 9.84e-01 -0.002920 9.92e-01
Synthesis of substrates in N-glycan biosythesis 58 9.69e-01 -0.002910 9.83e-01
Signaling by Hedgehog 121 9.56e-01 0.002890 9.79e-01
Post-translational modification: synthesis of GPI-anchored proteins 58 9.70e-01 -0.002860 9.83e-01
Xenobiotics 12 9.87e-01 -0.002620 9.93e-01
Cardiac conduction 87 9.71e-01 0.002290 9.83e-01
HCMV Early Events 74 9.73e-01 -0.002240 9.84e-01
Neddylation 219 9.57e-01 0.002130 9.79e-01
Golgi Associated Vesicle Biogenesis 55 9.79e-01 -0.002100 9.88e-01
SHC1 events in ERBB4 signaling 10 9.91e-01 0.002060 9.95e-01
Extension of Telomeres 51 9.81e-01 -0.001960 9.89e-01
Interleukin-20 family signaling 17 9.93e-01 0.001290 9.95e-01
Receptor-type tyrosine-protein phosphatases 12 9.94e-01 0.001270 9.95e-01
Vesicle-mediated transport 649 9.68e-01 0.000910 9.83e-01
ABC transporter disorders 71 9.90e-01 0.000845 9.95e-01
RNA Polymerase II Transcription 1206 9.61e-01 0.000843 9.79e-01
Host Interactions of HIV factors 130 9.87e-01 0.000801 9.93e-01
SLBP independent Processing of Histone Pre-mRNAs 10 9.97e-01 0.000778 9.97e-01
CLEC7A (Dectin-1) signaling 98 9.93e-01 0.000533 9.95e-01
Metabolism of water-soluble vitamins and cofactors 112 9.94e-01 0.000417 9.95e-01
Adaptive Immune System 758 9.89e-01 -0.000294 9.94e-01


Detailed Gene set reports



Peptide chain elongation

Peptide chain elongation
810
set Peptide chain elongation
setSize 88
pANOVA 6.36e-25
s.dist -0.635
p.adjustANOVA 4.35e-22



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
EEF2 -10214
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
EEF2 -10214
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EEF1A1 -7887
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
RPS24 -89
RPL23A 138
RPL6 1290
RPS4X 1825
RPS3A 3173
RPSA 5249
RPL22L1 8317
RPL3L 8978
RPS27L 9625


Eukaryotic Translation Elongation

Eukaryotic Translation Elongation
353
set Eukaryotic Translation Elongation
setSize 93
pANOVA 5.98e-26
s.dist -0.631
p.adjustANOVA 8.18e-23



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
EEF2 -10214
RPLP2 -10185
EEF1G -10158
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
EEF1D -9841
EEF1B2 -9772
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
EEF2 -10214
RPLP2 -10185
EEF1G -10158
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
EEF1D -9841
EEF1B2 -9772
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EEF1A1 -7887
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
EEF1A1P5 -5668
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
RPS24 -89
RPL23A 138
RPL6 1290
RPS4X 1825
RPS3A 3173
RPSA 5249
EEF1A2 7880
RPL22L1 8317
RPL3L 8978
RPS27L 9625


Viral mRNA Translation

Viral mRNA Translation
1318
set Viral mRNA Translation
setSize 88
pANOVA 1.04e-22
s.dist -0.604
p.adjustANOVA 2.37e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
RPS24 -89
RPL23A 138
RPL6 1290
RPS4X 1825
RPS3A 3173
GRSF1 4059
RPSA 5249
DNAJC3 7755
RPL22L1 8317
RPL3L 8978
RPS27L 9625


Eukaryotic Translation Termination

Eukaryotic Translation Termination
355
set Eukaryotic Translation Termination
setSize 92
pANOVA 5.46e-23
s.dist -0.595
p.adjustANOVA 1.87e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
TRMT112 -8912
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
APEH -8642
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
GSPT2 -972
RPS24 -89
RPL23A 138
N6AMT1 251
RPL6 1290
RPS4X 1825
RPS3A 3173
RPSA 5249
GSPT1 7510
ETF1 8214
RPL22L1 8317
RPL3L 8978
RPS27L 9625


Selenocysteine synthesis

Selenocysteine synthesis
1063
set Selenocysteine synthesis
setSize 92
pANOVA 8.98e-23
s.dist -0.592
p.adjustANOVA 2.37e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
SARS1 -6084
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
EEFSEC -5241
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
PSTK -2534
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
RPS24 -89
SEPHS2 -59
RPL23A 138
RPL6 1290
RPS4X 1825
RPS3A 3173
RPSA 5249
SEPSECS 7020
SECISBP2 7391
RPL22L1 8317
RPL3L 8978
RPS27L 9625


Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits
395
set Formation of a pool of free 40S subunits
setSize 100
pANOVA 1.32e-23
s.dist -0.579
p.adjustANOVA 6.02e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
EIF3B -8804
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EIF3I -7931
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
EIF3K -6222
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
EIF3D -5647
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
EIF3H -1365
RPS24 -89
RPL23A 138
RPL6 1290
RPS4X 1825
EIF3A 1969
RPS3A 3173
RPSA 5249
EIF3E 8272
RPL22L1 8317
EIF3M 8578
EIF1AX 8776
RPL3L 8978
RPS27L 9625
EIF3J 9804


Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
746
set Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize 94
pANOVA 1.41e-20
s.dist -0.554
p.adjustANOVA 2.75e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
UPF1 -6778
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
GSPT2 -972
RPS24 -89
RPL23A 138
RPL6 1290
RPS4X 1825
RPS3A 3173
PABPC1 4591
RPSA 5249
GSPT1 7510
ETF1 8214
RPL22L1 8317
RPL3L 8978
RPS27L 9625
NCBP1 10864
NCBP2 11208


Incretin synthesis, secretion, and inactivation

Incretin synthesis, secretion, and inactivation
525
set Incretin synthesis, secretion, and inactivation
setSize 10
pANOVA 0.0036
s.dist 0.532
p.adjustANOVA 0.0406



Top enriched genes

Top 20 genes
GeneID Gene Rank
TCF7L2 11426
SPCS2 11036
SEC11C 10820
SPCS3 10797
GNB3 6586
CTNNB1 5359
SPCS1 4379
FFAR4 4223
SEC11A 1049
DPP4 -128

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCF7L2 11426
SPCS2 11036
SEC11C 10820
SPCS3 10797
GNB3 6586
CTNNB1 5359
SPCS1 4379
FFAR4 4223
SEC11A 1049
DPP4 -128


Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
1185
set Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
setSize 10
pANOVA 0.0036
s.dist 0.532
p.adjustANOVA 0.0406



Top enriched genes

Top 20 genes
GeneID Gene Rank
TCF7L2 11426
SPCS2 11036
SEC11C 10820
SPCS3 10797
GNB3 6586
CTNNB1 5359
SPCS1 4379
FFAR4 4223
SEC11A 1049
DPP4 -128

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TCF7L2 11426
SPCS2 11036
SEC11C 10820
SPCS3 10797
GNB3 6586
CTNNB1 5359
SPCS1 4379
FFAR4 4223
SEC11A 1049
DPP4 -128


NF-kB is activated and signals survival

NF-kB is activated and signals survival
700
set NF-kB is activated and signals survival
setSize 12
pANOVA 0.00207
s.dist -0.513
p.adjustANOVA 0.0281



Top enriched genes

Top 20 genes
GeneID Gene Rank
RELA -9628
IRAK1 -9487
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
NFKBIA -4692
IKBKB -4462
UBC -4177
NGFR -2692
NFKB1 1266
TRAF6 2326

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELA -9628
IRAK1 -9487
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
NFKBIA -4692
IKBKB -4462
UBC -4177
NGFR -2692
NFKB1 1266
TRAF6 2326


WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4
1328
set WNT5A-dependent internalization of FZD4
setSize 13
pANOVA 0.00153
s.dist -0.508
p.adjustANOVA 0.0237



Top enriched genes

Top 20 genes
GeneID Gene Rank
DVL2 -9361
AP2M1 -8930
CLTB -8800
PRKCB -8270
AP2A2 -7814
AP2A1 -6826
PRKCA -6088
ARRB2 -5337
AP2S1 -3863
AP2B1 -3395
CLTA 509
CLTC 1283
FZD4 2728

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DVL2 -9361
AP2M1 -8930
CLTB -8800
PRKCB -8270
AP2A2 -7814
AP2A1 -6826
PRKCA -6088
ARRB2 -5337
AP2S1 -3863
AP2B1 -3395
CLTA 509
CLTC 1283
FZD4 2728


L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression
591
set L13a-mediated translational silencing of Ceruloplasmin expression
setSize 110
pANOVA 5.78e-20
s.dist -0.504
p.adjustANOVA 9.88e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
EIF3B -8804
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EIF3I -7931
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
RPL19 -6701
EIF4B -6655
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
EIF3K -6222
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
EIF3D -5647
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
EIF3H -1365
RPS24 -89
RPL23A 138
RPL6 1290
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
PABPC1 4591
RPSA 5249
EIF3E 8272
RPL22L1 8317
EIF3M 8578
EIF1AX 8776
RPL3L 8978
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF3J 9804
EIF4A2 10043
EIF2S3 10258
EIF4E 11624


DNA methylation

DNA methylation
247
set DNA methylation
setSize 20
pANOVA 0.000126
s.dist -0.495
p.adjustANOVA 0.00288



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNMT3B -9878.0
H2AZ1 -8776.0
H2BC12 -8742.0
DNMT1 -8737.0
DNMT3A -8681.0
H2BC17 -8346.0
H3C15 -8038.5
H2BC4 -7928.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
H2BC15 -4416.0
H2AC6 -4383.0
H2BC5 -3070.0
H2AZ2 -2475.0
UHRF1 1351.0
H2BU1 2721.0
H2AC20 3907.0
H3-3A 5193.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNMT3B -9878.0
H2AZ1 -8776.0
H2BC12 -8742.0
DNMT1 -8737.0
DNMT3A -8681.0
H2BC17 -8346.0
H3C15 -8038.5
H2BC4 -7928.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
H2BC15 -4416.0
H2AC6 -4383.0
H2BC5 -3070.0
H2AZ2 -2475.0
UHRF1 1351.0
H2BU1 2721.0
H2AC20 3907.0
H3-3A 5193.0


Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency
1010
set Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize 100
pANOVA 1.78e-17
s.dist -0.492
p.adjustANOVA 2.02e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
GCN1 -4393
RPL24 -3939
RPS26 -3701
ATF4 -3557
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
EIF2AK4 -2072
TRIB3 -1393
RPS24 -89
RPL23A 138
ATF3 451
CEBPB 621
RPL6 1290
RPS4X 1825
DDIT3 2994
RPS3A 3173
RPSA 5249
RPL22L1 8317
RPL3L 8978
ASNS 9230
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF2S3 10258
IMPACT 10622
CEBPG 11104
ATF2 11312


VLDLR internalisation and degradation

VLDLR internalisation and degradation
1313
set VLDLR internalisation and degradation
setSize 11
pANOVA 0.005
s.dist -0.489
p.adjustANOVA 0.051



Top enriched genes

Top 20 genes
GeneID Gene Rank
NR1H2 -9025
AP2M1 -8930
AP2A2 -7814
AP2A1 -6826
NR1H3 -4903
MYLIP -4778
VLDLR -4257
AP2S1 -3863
AP2B1 -3395
CLTA 509
CLTC 1283

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NR1H2 -9025
AP2M1 -8930
AP2A2 -7814
AP2A1 -6826
NR1H3 -4903
MYLIP -4778
VLDLR -4257
AP2S1 -3863
AP2B1 -3395
CLTA 509
CLTC 1283


tRNA processing in the mitochondrion

tRNA processing in the mitochondrion
1364
set tRNA processing in the mitochondrion
setSize 32
pANOVA 1.71e-06
s.dist -0.489
p.adjustANOVA 5.69e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-TS1 -10372
MT-TN -10345
MT-ATP8 -10332
MT-TC -9831
MT-ATP6 -9606
MT-TA -9596
MT-TP -9309
MT-ND4L -9074
MT-CO3 -8680
MT-ND3 -8450
MT-TV -8443
MT-TF -8294
MT-TL2 -7298
MT-TY -7272
MT-CYB -7017
MT-TM -6674
MT-ND1 -6593
MT-ND5 -6176
MT-CO2 -5700
MT-ND2 -4966

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-TS1 -10372
MT-TN -10345
MT-ATP8 -10332
MT-TC -9831
MT-ATP6 -9606
MT-TA -9596
MT-TP -9309
MT-ND4L -9074
MT-CO3 -8680
MT-ND3 -8450
MT-TV -8443
MT-TF -8294
MT-TL2 -7298
MT-TY -7272
MT-CYB -7017
MT-TM -6674
MT-ND1 -6593
MT-ND5 -6176
MT-CO2 -5700
MT-ND2 -4966
MT-TL1 -3853
MT-TE -3693
MT-RNR2 -3648
MT-RNR1 -3295
HSD17B10 -2865
ELAC2 -2324
MT-CO1 -685
MT-ND6 1775
MT-ND4 3305
PRORP 6071
TRMT10C 10717
TRNT1 11446


GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit
437
set GTP hydrolysis and joining of the 60S ribosomal subunit
setSize 111
pANOVA 6.92e-19
s.dist -0.487
p.adjustANOVA 1.05e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
EIF3B -8804
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EIF3I -7931
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
RPL19 -6701
EIF4B -6655
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
EIF3K -6222
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
EIF3D -5647
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
EIF3H -1365
RPS24 -89
RPL23A 138
RPL6 1290
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
RPSA 5249
EIF3E 8272
RPL22L1 8317
EIF3M 8578
EIF1AX 8776
RPL3L 8978
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF3J 9804
EIF5B 9825
EIF4A2 10043
EIF2S3 10258
EIF5 10905
EIF4E 11624


AKT phosphorylates targets in the nucleus

AKT phosphorylates targets in the nucleus
9
set AKT phosphorylates targets in the nucleus
setSize 10
pANOVA 0.00821
s.dist -0.483
p.adjustANOVA 0.0681



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKT2 -10102
FOXO4 -9911
AKT1 -9799
FOXO1 -8143
FOXO3 -7061
FOXO6 -6422
RPS6KB2 -6218
NR4A1 2131
AKT3 2465
CREB1 6457

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKT2 -10102
FOXO4 -9911
AKT1 -9799
FOXO1 -8143
FOXO3 -7061
FOXO6 -6422
RPS6KB2 -6218
NR4A1 2131
AKT3 2465
CREB1 6457


CDC6 association with the ORC:origin complex

CDC6 association with the ORC:origin complex
127
set CDC6 association with the ORC:origin complex
setSize 11
pANOVA 0.00597
s.dist 0.479
p.adjustANOVA 0.0562



Top enriched genes

Top 20 genes
GeneID Gene Rank
ORC3 11135
ORC5 9801
ORC4 9610
E2F3 7730
ORC2 7384
CDC6 6081
E2F2 4801
MCM8 3500
E2F1 3051
ORC6 1568
ORC1 1006

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ORC3 11135
ORC5 9801
ORC4 9610
E2F3 7730
ORC2 7384
CDC6 6081
E2F2 4801
MCM8 3500
E2F1 3051
ORC6 1568
ORC1 1006


Josephin domain DUBs

Josephin domain DUBs
585
set Josephin domain DUBs
setSize 10
pANOVA 0.00889
s.dist -0.478
p.adjustANOVA 0.071



Top enriched genes

Top 20 genes
GeneID Gene Rank
JOSD2 -9000
RPS27A -8388
JOSD1 -8057
UBA52 -7375
VCP -5402
UBB -4944
RAD23A -4413
UBC -4177
RAD23B -1815
ATXN3 7508

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
JOSD2 -9000
RPS27A -8388
JOSD1 -8057
UBA52 -7375
VCP -5402
UBB -4944
RAD23A -4413
UBC -4177
RAD23B -1815
ATXN3 7508


Cytosolic iron-sulfur cluster assembly

Cytosolic iron-sulfur cluster assembly
229
set Cytosolic iron-sulfur cluster assembly
setSize 13
pANOVA 0.00362
s.dist -0.466
p.adjustANOVA 0.0406



Top enriched genes

Top 20 genes
GeneID Gene Rank
NUBP2 -9876
POLD1 -8854
CIAO2B -8649
CIAO3 -8269
CIAO1 -7175
CIAPIN1 -6967
ERCC2 -6248
RTEL1 -6202
NDOR1 -4525
MMS19 -2760
NUBP1 -2271
BRIP1 6803
ABCB7 6813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NUBP2 -9876
POLD1 -8854
CIAO2B -8649
CIAO3 -8269
CIAO1 -7175
CIAPIN1 -6967
ERCC2 -6248
RTEL1 -6202
NDOR1 -4525
MMS19 -2760
NUBP1 -2271
BRIP1 6803
ABCB7 6813


Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
745
set Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize 114
pANOVA 4.58e-17
s.dist -0.455
p.adjustANOVA 4.47e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
MAGOH -9339
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
MAGOH -9339
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
PPP2R1A -7631
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
SMG5 -6880
UPF1 -6778
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
EIF4A3 -5845
RNPS1 -5842
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
SMG6 -5602
RPL5 -5445
RBM8A -5382
RPL26 -5374
RPL28 -5271
RPL13A -5249
CASC3 -5239
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
UPF3A -4433
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
GSPT2 -972
RPS24 -89
RPL23A 138
SMG1 158
SMG9 235
RPL6 1290
RPS4X 1825
RPS3A 3173
SMG7 4285
PABPC1 4591
RPSA 5249
PPP2CA 5682
SMG8 6313
MAGOHB 7179
DCP1A 7220
GSPT1 7510
UPF3B 8196
ETF1 8214
RPL22L1 8317
RPL3L 8978
RPS27L 9625
UPF2 10521
NCBP1 10864
NCBP2 11208
PNRC2 11638
PPP2R2A 11691


Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)
747
set Nonsense-Mediated Decay (NMD)
setSize 114
pANOVA 4.58e-17
s.dist -0.455
p.adjustANOVA 4.47e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
MAGOH -9339
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
MAGOH -9339
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
PPP2R1A -7631
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
SMG5 -6880
UPF1 -6778
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
RPL36A -5966
EIF4A3 -5845
RNPS1 -5842
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
SMG6 -5602
RPL5 -5445
RBM8A -5382
RPL26 -5374
RPL28 -5271
RPL13A -5249
CASC3 -5239
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
UPF3A -4433
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
GSPT2 -972
RPS24 -89
RPL23A 138
SMG1 158
SMG9 235
RPL6 1290
RPS4X 1825
RPS3A 3173
SMG7 4285
PABPC1 4591
RPSA 5249
PPP2CA 5682
SMG8 6313
MAGOHB 7179
DCP1A 7220
GSPT1 7510
UPF3B 8196
ETF1 8214
RPL22L1 8317
RPL3L 8978
RPS27L 9625
UPF2 10521
NCBP1 10864
NCBP2 11208
PNRC2 11638
PPP2R2A 11691


Cap-dependent Translation Initiation

Cap-dependent Translation Initiation
145
set Cap-dependent Translation Initiation
setSize 118
pANOVA 1.45e-17
s.dist -0.454
p.adjustANOVA 1.8e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
EIF3B -8804
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EIF3I -7931
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
RPL19 -6701
EIF4B -6655
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
EIF3K -6222
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
EIF3D -5647
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
EIF2B4 -4674
EIF4EBP1 -4513
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
EIF3H -1365
RPS24 -89
RPL23A 138
EIF2B2 679
EIF2B5 1132
RPL6 1290
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
EIF2B3 3221
PABPC1 4591
RPSA 5249
EIF3E 8272
RPL22L1 8317
EIF3M 8578
EIF1AX 8776
RPL3L 8978
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF2B1 9745
EIF3J 9804
EIF5B 9825
EIF4A2 10043
EIF2S3 10258
EIF5 10905
EIF4E 11624


Eukaryotic Translation Initiation

Eukaryotic Translation Initiation
354
set Eukaryotic Translation Initiation
setSize 118
pANOVA 1.45e-17
s.dist -0.454
p.adjustANOVA 1.8e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
EIF3F -10244
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
EIF3C -9873
RPL3 -9867
EIF4H -9779
RPL8 -9738
EIF3G -9710
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
EIF3B -8804
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
EIF3I -7931
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
EIF4G1 -7029
RPL35A -6977
RPL15 -6926
RPL19 -6701
EIF4B -6655
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
EIF3K -6222
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
EIF3D -5647
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
EIF2B4 -4674
EIF4EBP1 -4513
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
EIF3H -1365
RPS24 -89
RPL23A 138
EIF2B2 679
EIF2B5 1132
RPL6 1290
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
EIF2B3 3221
PABPC1 4591
RPSA 5249
EIF3E 8272
RPL22L1 8317
EIF3M 8578
EIF1AX 8776
RPL3L 8978
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF2B1 9745
EIF3J 9804
EIF5B 9825
EIF4A2 10043
EIF2S3 10258
EIF5 10905
EIF4E 11624


Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex
401
set Formation of the ternary complex, and subsequently, the 43S complex
setSize 51
pANOVA 4.73e-08
s.dist -0.442
p.adjustANOVA 2.31e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804
RPS11 -8677

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPS14 -8173
EIF3I -7931
RPS15A -7835
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPS6 -7364
RPS7 -6568
EIF3K -6222
RPS25 -5670
EIF3D -5647
RPS13 -5170
RPS26 -3701
RPS8 -3073
RPS20 -3024
EIF3H -1365
RPS24 -89
RPS4X 1825
EIF3A 1969
RPS3A 3173
RPSA 5249
EIF3E 8272
EIF3M 8578
EIF1AX 8776
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF3J 9804
EIF2S3 10258


GP1b-IX-V activation signalling

GP1b-IX-V activation signalling
430
set GP1b-IX-V activation signalling
setSize 10
pANOVA 0.0156
s.dist -0.442
p.adjustANOVA 0.102



Top enriched genes

Top 20 genes
GeneID Gene Rank
VWF -8805
GP9 -8734
FLNA -8138
GP1BB -7511
GP1BA -6740
PIK3R1 -5056
SRC -4258
GP5 -3922
RAF1 1476
YWHAZ 9618

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
VWF -8805
GP9 -8734
FLNA -8138
GP1BB -7511
GP1BA -6740
PIK3R1 -5056
SRC -4258
GP5 -3922
RAF1 1476
YWHAZ 9618


RNA Polymerase I Promoter Opening

RNA Polymerase I Promoter Opening
904
set RNA Polymerase I Promoter Opening
setSize 19
pANOVA 0.001
s.dist -0.436
p.adjustANOVA 0.0167



Top enriched genes

Top 20 genes
GeneID Gene Rank
MAPK3 -10100.0
H2AZ1 -8776.0
H2BC12 -8742.0
H2BC17 -8346.0
H3C15 -8038.5
UBTF -8001.0
H2BC4 -7928.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
H2BC15 -4416.0
H2AC6 -4383.0
H2BC5 -3070.0
H2AZ2 -2475.0
H2BU1 2721.0
H2AC20 3907.0
H3-3A 5193.0
MBD2 9375.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MAPK3 -10100.0
H2AZ1 -8776.0
H2BC12 -8742.0
H2BC17 -8346.0
H3C15 -8038.5
UBTF -8001.0
H2BC4 -7928.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
H2BC15 -4416.0
H2AC6 -4383.0
H2BC5 -3070.0
H2AZ2 -2475.0
H2BU1 2721.0
H2AC20 3907.0
H3-3A 5193.0
MBD2 9375.0


Condensation of Prometaphase Chromosomes

Condensation of Prometaphase Chromosomes
205
set Condensation of Prometaphase Chromosomes
setSize 11
pANOVA 0.0125
s.dist 0.435
p.adjustANOVA 0.0883



Top enriched genes

Top 20 genes
GeneID Gene Rank
SMC4 11305
SMC2 10493
CDK1 9135
NCAPG 8163
NCAPH 6083
CCNB1 5971
CCNB2 5588
CSNK2A1 3172
CSNK2A2 2068
CSNK2B 178
NCAPD2 -1837

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SMC4 11305
SMC2 10493
CDK1 9135
NCAPG 8163
NCAPH 6083
CCNB1 5971
CCNB2 5588
CSNK2A1 3172
CSNK2A2 2068
CSNK2B 178
NCAPD2 -1837


Trafficking of GluR2-containing AMPA receptors

Trafficking of GluR2-containing AMPA receptors
1251
set Trafficking of GluR2-containing AMPA receptors
setSize 12
pANOVA 0.00931
s.dist -0.433
p.adjustANOVA 0.0728



Top enriched genes

Top 20 genes
GeneID Gene Rank
PICK1 -9237
AP2M1 -8930
PRKCB -8270
AP2A2 -7814
AP2A1 -6826
PRKCA -6088
AP2S1 -3863
AP2B1 -3395
TSPAN7 -2479
GRIP1 -1255
NSF 2368
GRIA4 6394

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PICK1 -9237
AP2M1 -8930
PRKCB -8270
AP2A2 -7814
AP2A1 -6826
PRKCA -6088
AP2S1 -3863
AP2B1 -3395
TSPAN7 -2479
GRIP1 -1255
NSF 2368
GRIA4 6394


Regulation of FZD by ubiquitination

Regulation of FZD by ubiquitination
954
set Regulation of FZD by ubiquitination
setSize 16
pANOVA 0.00272
s.dist -0.433
p.adjustANOVA 0.0338



Top enriched genes

Top 20 genes
GeneID Gene Rank
FZD8 -10178
LRP6 -8827
RPS27A -8388
LRP5 -7595
UBA52 -7375
LGR4 -6601
ZNRF3 -6501
FZD6 -5293
UBB -4944
LGR6 -4753
UBC -4177
RSPO4 -4068
RNF43 -2783
FZD5 1477
FZD4 2728
USP8 11545

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FZD8 -10178
LRP6 -8827
RPS27A -8388
LRP5 -7595
UBA52 -7375
LGR4 -6601
ZNRF3 -6501
FZD6 -5293
UBB -4944
LGR6 -4753
UBC -4177
RSPO4 -4068
RNF43 -2783
FZD5 1477
FZD4 2728
USP8 11545


Presynaptic phase of homologous DNA pairing and strand exchange

Presynaptic phase of homologous DNA pairing and strand exchange
854
set Presynaptic phase of homologous DNA pairing and strand exchange
setSize 39
pANOVA 3.16e-06
s.dist 0.431
p.adjustANOVA 9.81e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD51B 11348
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
RAD17 9946
RFC4 9891
BRCA2 9757
RAD9B 9234
RAD51C 9158
HUS1 9132
BARD1 9023
TOPBP1 8826
BRCA1 8138
RFC3 7972
CHEK1 7791
BRIP1 6803
RAD1 6800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51B 11348
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
RAD17 9946
RFC4 9891
BRCA2 9757
RAD9B 9234
RAD51C 9158
HUS1 9132
BARD1 9023
TOPBP1 8826
BRCA1 8138
RFC3 7972
CHEK1 7791
BRIP1 6803
RAD1 6800
RAD51 6337
RPA2 5538
ATR 4908
BLM 4120
WRN 4117
RHNO1 3076
EXO1 2398
RPA3 2293
ATRIP 2287
MRE11 2275
RFC5 919
KAT5 -301
XRCC2 -645
RFC2 -697
ATM -768
RAD9A -1761
TOP3A -2746
RAD51D -2821
RPA1 -4771


SUMOylation of DNA methylation proteins

SUMOylation of DNA methylation proteins
1048
set SUMOylation of DNA methylation proteins
setSize 16
pANOVA 0.00305
s.dist -0.428
p.adjustANOVA 0.0369



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNMT3B -9878
RING1 -9757
CBX4 -9599
CBX2 -9370
DNMT1 -8737
PHC1 -8697
DNMT3A -8681
PHC2 -6906
PCGF2 -6871
SCMH1 -6232
UBE2I -5999
CBX8 -4050
PHC3 4542
BMI1 5940
RNF2 9121
SUMO1 10348

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNMT3B -9878
RING1 -9757
CBX4 -9599
CBX2 -9370
DNMT1 -8737
PHC1 -8697
DNMT3A -8681
PHC2 -6906
PCGF2 -6871
SCMH1 -6232
UBE2I -5999
CBX8 -4050
PHC3 4542
BMI1 5940
RNF2 9121
SUMO1 10348


Selenoamino acid metabolism

Selenoamino acid metabolism
1062
set Selenoamino acid metabolism
setSize 114
pANOVA 6.82e-15
s.dist -0.422
p.adjustANOVA 6.22e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
QARS1 -9481
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
QARS1 -9481
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
AHCY -9076
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
SCLY -6549
RPL14 -6402
RPL21 -6288
SARS1 -6084
RPL36A -5966
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
EEFSEC -5241
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
AIMP2 -3560
RPS8 -3073
RPS20 -3024
PSTK -2534
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
GNMT -2001
GSR -1712
RPS24 -89
SEPHS2 -59
RPL23A 138
IARS1 657
MARS1 916
RPL6 1290
RPS4X 1825
INMT 2731
RPS3A 3173
TXNRD1 4413
KARS1 4630
RPSA 5249
SEPSECS 7020
HNMT 7288
SECISBP2 7391
EPRS1 7458
CBS 7520
CTH 7660
RPL22L1 8317
RPL3L 8978
RPS27L 9625
LARS1 9915
PAPSS1 10005
EEF1E1 10288
RARS1 10725
PAPSS2 10749
DARS1 11223
AIMP1 11596


Processing and activation of SUMO

Processing and activation of SUMO
855
set Processing and activation of SUMO
setSize 10
pANOVA 0.0218
s.dist 0.419
p.adjustANOVA 0.132



Top enriched genes

Top 20 genes
GeneID Gene Rank
SUMO1 10348
SENP5 9908
SENP2 9874
RWDD3 9390
SUMO2 9303
SENP1 8191
UBA2 6139
SUMO3 4470
UBE2I -5999
SAE1 -8538

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SUMO1 10348
SENP5 9908
SENP2 9874
RWDD3 9390
SUMO2 9303
SENP1 8191
UBA2 6139
SUMO3 4470
UBE2I -5999
SAE1 -8538


SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane
1043
set SRP-dependent cotranslational protein targeting to membrane
setSize 111
pANOVA 1.48e-13
s.dist -0.406
p.adjustANOVA 1.13e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
RPS5 -9130
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
DDOST -8281
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
SSR4 -6292
RPN1 -6289
RPL21 -6288
RPL36A -5966
SRPRA -5918
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
RPL10A -4820
RPL23 -4456
RPL24 -3939
RPS26 -3701
RPS8 -3073
RPS20 -3024
SEC61B -2646
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
SEC61A1 -977
RPS24 -89
RPL23A 138
SEC11A 1049
RPL6 1290
RPS4X 1825
SSR2 2011
RPS3A 3173
SPCS1 4379
SRP68 4427
RPN2 4596
RPSA 5249
SRP72 6253
SRPRB 6450
SRP14 6458
SSR1 7422
SSR3 8240
RPL22L1 8317
RPL3L 8978
SEC61A2 9571
RPS27L 9625
TRAM1 9735
SPCS3 10797
SEC11C 10820
SRP9 10867
SRP19 11022
SPCS2 11036
SEC61G 11123
SRP54 11724


Olfactory Signaling Pathway

Olfactory Signaling Pathway
768
set Olfactory Signaling Pathway
setSize 61
pANOVA 5.11e-08
s.dist 0.403
p.adjustANOVA 2.41e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
OR2AT4 11604
OR8A1 11448
OR2M3 11395
RTP4 11292
OR10H5 10984
OR6Y1 10944
OR10G3 10629
OR2C3 10611
OR6K3 10427
OR7C1 10226
OR2A5 9979
OR2T33 9961
OR2I1P 9910
OR2G6 9516
OR10A6 9513
OR2L2 9392
OR2V2 9225
OR52K1 9191
OR5A2 9048
OR7A5 9014

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
OR2AT4 11604
OR8A1 11448
OR2M3 11395
RTP4 11292
OR10H5 10984
OR6Y1 10944
OR10G3 10629
OR2C3 10611
OR6K3 10427
OR7C1 10226
OR2A5 9979
OR2T33 9961
OR2I1P 9910
OR2G6 9516
OR10A6 9513
OR2L2 9392
OR2V2 9225
OR52K1 9191
OR5A2 9048
OR7A5 9014
REEP3 8840
OR4E1 8769
OR6C75 8698
OR1I1 8672
OR1D2 8419
OR51L1 8101
OR5AS1 8048
RTP5 7976
OR1C1 7818
REEP1 7706
OR56A1 7701
OR7G2 7525
OR2M4 7488
OR2H2 7445
OR52N4 6649
OR14J1 6491
OR4D9 6454
OR5A1 5489
REEP5 5355
OR7D4 4655
OR4D1 4519
OR5AU1 3772
OR5AN1 3574
OR4K17 1760
OR1M1 1175
OR1A1 1065
OR14L1P 848
REEP2 459
OR2B11 252
OR7A17 -658
OR52A1 -2141
OR2W3 -2772
OR10AC1 -3145
OR7D2 -3238
OR2A7 -3414
OR3A3 -3468
GNB1 -5109
GNAL -6950
REEP4 -8128
OR2A1 -8172
REEP6 -10290


Homologous DNA Pairing and Strand Exchange

Homologous DNA Pairing and Strand Exchange
502
set Homologous DNA Pairing and Strand Exchange
setSize 42
pANOVA 6.3e-06
s.dist 0.403
p.adjustANOVA 0.000191



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD51B 11348
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
RAD17 9946
RFC4 9891
BRCA2 9757
RAD9B 9234
RAD51C 9158
HUS1 9132
BARD1 9023
TOPBP1 8826
BRCA1 8138
RFC3 7972
RAD51AP1 7821
CHEK1 7791
BRIP1 6803

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51B 11348
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
RAD17 9946
RFC4 9891
BRCA2 9757
RAD9B 9234
RAD51C 9158
HUS1 9132
BARD1 9023
TOPBP1 8826
BRCA1 8138
RFC3 7972
RAD51AP1 7821
CHEK1 7791
BRIP1 6803
RAD1 6800
RAD51 6337
RPA2 5538
ATR 4908
BLM 4120
WRN 4117
PALB2 3783
RHNO1 3076
EXO1 2398
RPA3 2293
ATRIP 2287
MRE11 2275
RFC5 919
KAT5 -301
XRCC2 -645
RFC2 -697
ATM -768
RAD9A -1761
TOP3A -2746
RAD51D -2821
RPA1 -4771
XRCC3 -8531


FOXO-mediated transcription of cell death genes

FOXO-mediated transcription of cell death genes
373
set FOXO-mediated transcription of cell death genes
setSize 16
pANOVA 0.00558
s.dist -0.4
p.adjustANOVA 0.0534



Top enriched genes

Top 20 genes
GeneID Gene Rank
FOXO4 -9911
PINK1 -9108
STK11 -8976
CREBBP -8918
BBC3 -8875
FOXO1 -8143
FOXO3 -7061
CITED2 -5315
FASLG -4042
EP300 -2667
BCL6 -2615
NFYA -556
BCL2L11 196
DDIT3 2994
NFYC 5216
NFYB 7833

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOXO4 -9911
PINK1 -9108
STK11 -8976
CREBBP -8918
BBC3 -8875
FOXO1 -8143
FOXO3 -7061
CITED2 -5315
FASLG -4042
EP300 -2667
BCL6 -2615
NFYA -556
BCL2L11 196
DDIT3 2994
NFYC 5216
NFYB 7833


A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis
1
set A tetrasaccharide linker sequence is required for GAG synthesis
setSize 18
pANOVA 0.00339
s.dist -0.399
p.adjustANOVA 0.0392



Top enriched genes

Top 20 genes
GeneID Gene Rank
B3GAT3 -9818
XYLT1 -9723
GPC4 -9454
B3GALT6 -8920
XYLT2 -8645
B4GALT7 -8207
GPC1 -8099
GPC2 -7735
HSPG2 -5458
CSPG4 -4429
B3GAT2 -1900
SDC4 -1368
B3GAT1 18
SDC3 1680
VCAN 1854
DCN 2926
SDC2 3889
AGRN 6202

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3GAT3 -9818
XYLT1 -9723
GPC4 -9454
B3GALT6 -8920
XYLT2 -8645
B4GALT7 -8207
GPC1 -8099
GPC2 -7735
HSPG2 -5458
CSPG4 -4429
B3GAT2 -1900
SDC4 -1368
B3GAT1 18
SDC3 1680
VCAN 1854
DCN 2926
SDC2 3889
AGRN 6202


rRNA processing in the mitochondrion

rRNA processing in the mitochondrion
1358
set rRNA processing in the mitochondrion
setSize 29
pANOVA 0.000227
s.dist -0.395
p.adjustANOVA 0.00468



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-ATP8 -10332
MT-ATP6 -9606
MT-ND4L -9074
MT-CO3 -8680
MT-ND3 -8450
MT-TV -8443
MT-TF -8294
MT-TL2 -7298
MT-CYB -7017
MT-TM -6674
MT-ND1 -6593
MT-ND5 -6176
MRM1 -5820
MTERF4 -5707
MT-CO2 -5700
MT-ND2 -4966
MT-TL1 -3853
MT-RNR2 -3648
MT-RNR1 -3295
HSD17B10 -2865

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP8 -10332
MT-ATP6 -9606
MT-ND4L -9074
MT-CO3 -8680
MT-ND3 -8450
MT-TV -8443
MT-TF -8294
MT-TL2 -7298
MT-CYB -7017
MT-TM -6674
MT-ND1 -6593
MT-ND5 -6176
MRM1 -5820
MTERF4 -5707
MT-CO2 -5700
MT-ND2 -4966
MT-TL1 -3853
MT-RNR2 -3648
MT-RNR1 -3295
HSD17B10 -2865
ELAC2 -2324
MRM3 -2058
MRM2 -1116
MT-CO1 -685
MT-ND4 3305
NSUN4 4732
PRORP 6071
TFB1M 6776
TRMT10C 10717


TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1192
set TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
setSize 16
pANOVA 0.00639
s.dist -0.394
p.adjustANOVA 0.0583



Top enriched genes

Top 20 genes
GeneID Gene Rank
PARD6A -9275
RPS27A -8388
TGFB1 -8091
TGFBR2 -8064
PRKCZ -7701
UBA52 -7375
ARHGEF18 -5836
CGN -5578
UBB -4944
F11R -4885
UBC -4177
PARD3 -2235
SMURF1 -1891
TGFBR1 5352
FKBP1A 6665
RHOA 7611

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PARD6A -9275
RPS27A -8388
TGFB1 -8091
TGFBR2 -8064
PRKCZ -7701
UBA52 -7375
ARHGEF18 -5836
CGN -5578
UBB -4944
F11R -4885
UBC -4177
PARD3 -2235
SMURF1 -1891
TGFBR1 5352
FKBP1A 6665
RHOA 7611


Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
50
set Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize 59
pANOVA 2.08e-07
s.dist -0.391
p.adjustANOVA 8.61e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF4H -9779
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF4H -9779
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPS14 -8173
EIF3I -7931
RPS15A -7835
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPS6 -7364
EIF4G1 -7029
EIF4B -6655
RPS7 -6568
EIF3K -6222
RPS25 -5670
EIF3D -5647
RPS13 -5170
EIF4EBP1 -4513
RPS26 -3701
RPS8 -3073
RPS20 -3024
EIF3H -1365
RPS24 -89
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
PABPC1 4591
RPSA 5249
EIF3E 8272
EIF3M 8578
EIF1AX 8776
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF3J 9804
EIF4A2 10043
EIF2S3 10258
EIF4E 11624


WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
1327
set WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize 11
pANOVA 0.0249
s.dist -0.391
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP2M1 -8930
CLTB -8800
AP2A2 -7814
FZD2 -7097
AP2A1 -6826
AP2S1 -3863
AP2B1 -3395
CLTA 509
CLTC 1283
FZD5 1477
ROR1 3385

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP2M1 -8930
CLTB -8800
AP2A2 -7814
FZD2 -7097
AP2A1 -6826
AP2S1 -3863
AP2B1 -3395
CLTA 509
CLTC 1283
FZD5 1477
ROR1 3385


Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
1177
set Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
setSize 12
pANOVA 0.0193
s.dist -0.39
p.adjustANOVA 0.121



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTGS2 -10227
PTGES2 -9522
PRXL2B -9063
AKR1C3 -7972
PTGDS -6443
PTGS1 -6287
PTGR2 -5053
CBR1 -4667
PTGES 202
TBXAS1 500
HPGD 4018
PTGES3 10886

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGS2 -10227
PTGES2 -9522
PRXL2B -9063
AKR1C3 -7972
PTGDS -6443
PTGS1 -6287
PTGR2 -5053
CBR1 -4667
PTGES 202
TBXAS1 500
HPGD 4018
PTGES3 10886


Pexophagy

Pexophagy
816
set Pexophagy
setSize 11
pANOVA 0.0251
s.dist -0.39
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
PEX5 -8871
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
UBC -4177
USP30 -2323
ATM -768
NBR1 483
MAP1LC3B 1057
EPAS1 3063

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PEX5 -8871
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
UBC -4177
USP30 -2323
ATM -768
NBR1 483
MAP1LC3B 1057
EPAS1 3063


Translation initiation complex formation

Translation initiation complex formation
1272
set Translation initiation complex formation
setSize 58
pANOVA 2.9e-07
s.dist -0.389
p.adjustANOVA 1.17e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF4H -9779
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF4H -9779
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPS14 -8173
EIF3I -7931
RPS15A -7835
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPS6 -7364
EIF4G1 -7029
EIF4B -6655
RPS7 -6568
EIF3K -6222
RPS25 -5670
EIF3D -5647
RPS13 -5170
RPS26 -3701
RPS8 -3073
RPS20 -3024
EIF3H -1365
RPS24 -89
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
PABPC1 4591
RPSA 5249
EIF3E 8272
EIF3M 8578
EIF1AX 8776
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF3J 9804
EIF4A2 10043
EIF2S3 10258
EIF4E 11624


Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication
530
set Influenza Viral RNA Transcription and Replication
setSize 135
pANOVA 9.54e-15
s.dist -0.386
p.adjustANOVA 7.67e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPL37 -10308
POLR2L -10282
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
POM121C -9374
GTF2F1 -9355
FAU -9334
RPS18 -9321
RPS27 -9308

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPL37 -10308
POLR2L -10282
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
POM121C -9374
GTF2F1 -9355
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
POLR2I -9194
POLR2F -9158
RPS5 -9130
NUP210 -9099
POLR2E -9034
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
POM121 -8910
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
RPL32 -8070
POLR2G -8006
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
POLR2A -6255
POLR2J -5993
RPL36A -5966
NUP188 -5843
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
PARP1 -4864
RPL10A -4820
POLR2H -4752
RPL23 -4456
RPL24 -3939
RPS26 -3701
SEC13 -3159
NUP62 -3119
RPS8 -3073
RPS20 -3024
POLR2C -2998
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
IPO5 -1917
AAAS -1609
RPS24 -89
NDC1 -77
RPL23A 138
RPL6 1290
RPS4X 1825
NUP214 2090
NUP98 2149
NUP93 3043
NUP155 3103
RPS3A 3173
NUP160 3296
NUP205 3520
NUP153 3654
NUP37 3973
GRSF1 4059
NUP88 4512
POLR2D 4912
TPR 4956
RPSA 5249
GTF2F2 5332
NUP133 5417
RANBP2 5691
RAE1 6124
NUP85 6578
NUP58 6817
NUP50 7082
POLR2B 7601
DNAJC3 7755
NUP107 7988
RPL22L1 8317
HSP90AA1 8431
NUP35 8941
RPL3L 8978
RPS27L 9625
SEH1L 9849
POLR2K 9927
NUP43 10569
NUP42 10900
NUP54 11540


MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
622
set MET activates RAP1 and RAC1
setSize 10
pANOVA 0.0351
s.dist 0.385
p.adjustANOVA 0.183



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAP1A 11696
RAC1 9649
GAB1 8927
CRK 8347
HGF 8211
RAP1B 7493
DOCK7 6267
GRB2 75
CRKL -3376
RAPGEF1 -7965

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAP1A 11696
RAC1 9649
GAB1 8927
CRK 8347
HGF 8211
RAP1B 7493
DOCK7 6267
GRB2 75
CRKL -3376
RAPGEF1 -7965


Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
1005
set Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
setSize 26
pANOVA 0.000729
s.dist 0.383
p.adjustANOVA 0.0126



Top enriched genes

Top 20 genes
GeneID Gene Rank
RAD51B 11348
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
BRCA2 9757
RAD51C 9158
BARD1 9023
BRCA1 8138
RAD51AP1 7821
BRIP1 6803
RAD51 6337
BLM 4120
WRN 4117
PALB2 3783
EXO1 2398
MRE11 2275
KAT5 -301

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RAD51B 11348
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
BRCA2 9757
RAD51C 9158
BARD1 9023
BRCA1 8138
RAD51AP1 7821
BRIP1 6803
RAD51 6337
BLM 4120
WRN 4117
PALB2 3783
EXO1 2398
MRE11 2275
KAT5 -301
XRCC2 -645
ATM -768
TOP3A -2746
RAD51D -2821
RTEL1 -6202
XRCC3 -8531


Signaling by Leptin

Signaling by Leptin
1107
set Signaling by Leptin
setSize 10
pANOVA 0.037
s.dist -0.381
p.adjustANOVA 0.188



Top enriched genes

Top 20 genes
GeneID Gene Rank
SOCS3 -10318
IRS1 -9921
IRS2 -9048
STAT5A -7264
STAT5B -6114
SH2B1 -4573
LEPR -1573
PTPN11 -619
STAT3 2791
JAK2 11299

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SOCS3 -10318
IRS1 -9921
IRS2 -9048
STAT5A -7264
STAT5B -6114
SH2B1 -4573
LEPR -1573
PTPN11 -619
STAT3 2791
JAK2 11299


Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition
1018
set Ribosomal scanning and start codon recognition
setSize 58
pANOVA 5.74e-07
s.dist -0.379
p.adjustANOVA 2.12e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF4H -9779
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EIF3F -10244
RPS2 -10243
RPS29 -10049
RPS17 -9962
EIF3C -9873
EIF4H -9779
EIF3G -9710
RPS16 -9633
RPS21 -9530
RPS4Y1 -9458
RPS12 -9407
FAU -9334
RPS18 -9321
RPS27 -9308
EIF3L -9269
RPS10 -9222
RPS5 -9130
RPS28 -8941
RPS19 -8814
EIF3B -8804
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPS14 -8173
EIF3I -7931
RPS15A -7835
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPS6 -7364
EIF4G1 -7029
EIF4B -6655
RPS7 -6568
EIF3K -6222
RPS25 -5670
EIF3D -5647
RPS13 -5170
RPS26 -3701
RPS8 -3073
RPS20 -3024
EIF3H -1365
RPS24 -89
EIF4A1 1541
RPS4X 1825
EIF3A 1969
RPS3A 3173
RPSA 5249
EIF3E 8272
EIF3M 8578
EIF1AX 8776
EIF2S2 9317
EIF2S1 9563
RPS27L 9625
EIF3J 9804
EIF4A2 10043
EIF2S3 10258
EIF5 10905
EIF4E 11624


Pausing and recovery of Tat-mediated HIV elongation

Pausing and recovery of Tat-mediated HIV elongation
808
set Pausing and recovery of Tat-mediated HIV elongation
setSize 30
pANOVA 0.000324
s.dist -0.379
p.adjustANOVA 0.0059



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998
NELFE -2081
ELOC 1200
SUPT4H1 1271
SUPT16H 2912
ELOA 2983
POLR2D 4912
GTF2F2 5332
POLR2B 7601
TCEA1 8287
POLR2K 9927


Tat-mediated HIV elongation arrest and recovery

Tat-mediated HIV elongation arrest and recovery
1220
set Tat-mediated HIV elongation arrest and recovery
setSize 30
pANOVA 0.000324
s.dist -0.379
p.adjustANOVA 0.0059



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998
NELFE -2081
ELOC 1200
SUPT4H1 1271
SUPT16H 2912
ELOA 2983
POLR2D 4912
GTF2F2 5332
POLR2B 7601
TCEA1 8287
POLR2K 9927


HS-GAG degradation

HS-GAG degradation
489
set HS-GAG degradation
setSize 16
pANOVA 0.00872
s.dist -0.379
p.adjustANOVA 0.071



Top enriched genes

Top 20 genes
GeneID Gene Rank
SGSH -10002
NAGLU -9725
GPC4 -9454
GPC1 -8099
GPC2 -7735
GUSB -5871
HSPG2 -5458
IDS -5405
IDUA -4267
HPSE -2954
SDC4 -1368
GLB1L 62
SDC3 1680
GLB1 2354
SDC2 3889
AGRN 6202

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SGSH -10002
NAGLU -9725
GPC4 -9454
GPC1 -8099
GPC2 -7735
GUSB -5871
HSPG2 -5458
IDS -5405
IDUA -4267
HPSE -2954
SDC4 -1368
GLB1L 62
SDC3 1680
GLB1 2354
SDC2 3889
AGRN 6202


Interleukin-2 signaling

Interleukin-2 signaling
563
set Interleukin-2 signaling
setSize 11
pANOVA 0.0316
s.dist -0.374
p.adjustANOVA 0.173



Top enriched genes

Top 20 genes
GeneID Gene Rank
IL2RB -10303
PTK2B -8809
JAK1 -8196
STAT5A -7264
STAT5B -6114
LCK -4371
JAK3 -2805
SHC1 137
SYK 2432
IL2RA 2703
IL2RG 4503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IL2RB -10303
PTK2B -8809
JAK1 -8196
STAT5A -7264
STAT5B -6114
LCK -4371
JAK3 -2805
SHC1 137
SYK 2432
IL2RA 2703
IL2RG 4503


p75NTR signals via NF-kB

p75NTR signals via NF-kB
1354
set p75NTR signals via NF-kB
setSize 15
pANOVA 0.0127
s.dist -0.372
p.adjustANOVA 0.0887



Top enriched genes

Top 20 genes
GeneID Gene Rank
RELA -9628
IRAK1 -9487
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
NFKBIA -4692
IKBKB -4462
UBC -4177
NGFR -2692
RIPK2 156
NFKB1 1266
TRAF6 2326
MYD88 4098
PRKCI 4288

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RELA -9628
IRAK1 -9487
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
NFKBIA -4692
IKBKB -4462
UBC -4177
NGFR -2692
RIPK2 156
NFKB1 1266
TRAF6 2326
MYD88 4098
PRKCI 4288


Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Estrogen-dependent nuclear events downstream of ESR-membrane signaling
352
set Estrogen-dependent nuclear events downstream of ESR-membrane signaling
setSize 22
pANOVA 0.00255
s.dist -0.372
p.adjustANOVA 0.0329



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKT2 -10102
MAPK3 -10100
FOS -9975
AKT1 -9799
HBEGF -8469
AREG -8418
ELK1 -7817
SRF -7749
EREG -7409
FOXO3 -7061
CCND1 -5765
TGFA -5162
PTK2 -2003
MAPK1 -1844
CDKN1B -1307
EGF 514
UHMK1 696
BCL2 2357
AKT3 2465
EPGN 3595

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKT2 -10102
MAPK3 -10100
FOS -9975
AKT1 -9799
HBEGF -8469
AREG -8418
ELK1 -7817
SRF -7749
EREG -7409
FOXO3 -7061
CCND1 -5765
TGFA -5162
PTK2 -2003
MAPK1 -1844
CDKN1B -1307
EGF 514
UHMK1 696
BCL2 2357
AKT3 2465
EPGN 3595
CREB1 6457
XPO1 11455


Activation of Matrix Metalloproteinases

Activation of Matrix Metalloproteinases
41
set Activation of Matrix Metalloproteinases
setSize 24
pANOVA 0.00164
s.dist -0.371
p.adjustANOVA 0.0247



Top enriched genes

Top 20 genes
GeneID Gene Rank
MMP9 -10277
FURIN -10276
TPSAB1 -9796
MMP14 -8825
CTSG -7910
MMP15 -7494
ELANE -6634
COL18A1 -6216
MMP8 -6018
TIMP2 -5731
MMP24 -5305
PRSS2 -4636
KLKB1 -4063
MMP7 -2929
MMP1 -2757
MMP25 -2400
PRSS1 -1563
CTSV -759
MMP11 -513
MMP17 -8

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MMP9 -10277
FURIN -10276
TPSAB1 -9796
MMP14 -8825
CTSG -7910
MMP15 -7494
ELANE -6634
COL18A1 -6216
MMP8 -6018
TIMP2 -5731
MMP24 -5305
PRSS2 -4636
KLKB1 -4063
MMP7 -2929
MMP1 -2757
MMP25 -2400
PRSS1 -1563
CTSV -759
MMP11 -513
MMP17 -8
TIMP1 1642
KLK2 4164
CTSK 7149
PLG 8929


Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)

Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
267
set Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)
setSize 12
pANOVA 0.0271
s.dist -0.369
p.adjustANOVA 0.154



Top enriched genes

Top 20 genes
GeneID Gene Rank
F12 -9231
VWF -8805
GP9 -8734
GP1BB -7511
GP1BA -6740
TPST2 -6004
KLKB1 -4063
GP5 -3922
TPST1 -2552
GGCX -505
F8 6093
SERPING1 11201

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F12 -9231
VWF -8805
GP9 -8734
GP1BB -7511
GP1BA -6740
TPST2 -6004
KLKB1 -4063
GP5 -3922
TPST1 -2552
GGCX -505
F8 6093
SERPING1 11201


Diseases of hemostasis

Diseases of hemostasis
295
set Diseases of hemostasis
setSize 12
pANOVA 0.0271
s.dist -0.369
p.adjustANOVA 0.154



Top enriched genes

Top 20 genes
GeneID Gene Rank
F12 -9231
VWF -8805
GP9 -8734
GP1BB -7511
GP1BA -6740
TPST2 -6004
KLKB1 -4063
GP5 -3922
TPST1 -2552
GGCX -505
F8 6093
SERPING1 11201

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F12 -9231
VWF -8805
GP9 -8734
GP1BB -7511
GP1BA -6740
TPST2 -6004
KLKB1 -4063
GP5 -3922
TPST1 -2552
GGCX -505
F8 6093
SERPING1 11201


Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
176
set Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
setSize 12
pANOVA 0.0312
s.dist 0.359
p.adjustANOVA 0.172



Top enriched genes

Top 20 genes
GeneID Gene Rank
YWHAB 11092
YWHAZ 9618
CDK1 9135
CHEK1 7791
YWHAE 6642
CCNB1 5971
CHEK2 5577
WEE1 4830
YWHAH 3131
YWHAQ 2580
YWHAG -3999
SFN -6586

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
YWHAB 11092
YWHAZ 9618
CDK1 9135
CHEK1 7791
YWHAE 6642
CCNB1 5971
CHEK2 5577
WEE1 4830
YWHAH 3131
YWHAQ 2580
YWHAG -3999
SFN -6586


Establishment of Sister Chromatid Cohesion

Establishment of Sister Chromatid Cohesion
350
set Establishment of Sister Chromatid Cohesion
setSize 11
pANOVA 0.0399
s.dist 0.358
p.adjustANOVA 0.194



Top enriched genes

Top 20 genes
GeneID Gene Rank
ESCO1 11353
SMC3 10955
PDS5B 7409
RAD21 6566
STAG2 6346
ESCO2 4045
PDS5A 3914
WAPL 2842
CDCA5 1040
STAG1 71
SMC1A -3594

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ESCO1 11353
SMC3 10955
PDS5B 7409
RAD21 6566
STAG2 6346
ESCO2 4045
PDS5A 3914
WAPL 2842
CDCA5 1040
STAG1 71
SMC1A -3594


Pre-NOTCH Processing in Golgi

Pre-NOTCH Processing in Golgi
849
set Pre-NOTCH Processing in Golgi
setSize 18
pANOVA 0.00904
s.dist -0.355
p.adjustANOVA 0.0714



Top enriched genes

Top 20 genes
GeneID Gene Rank
MFNG -10322
FURIN -10276
ST3GAL4 -9287
ATP2A3 -8695
NOTCH1 -8307
RFNG -7532
ST3GAL3 -6159
B4GALT1 -6125
NOTCH3 -5144
NOTCH2 -5057
LFNG -4880
NOTCH4 -3355
ATP2A2 -2559
ATP2A1 -2334
SEL1L 4617
RAB6A 8257
ST3GAL6 9285
TMED2 9346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MFNG -10322
FURIN -10276
ST3GAL4 -9287
ATP2A3 -8695
NOTCH1 -8307
RFNG -7532
ST3GAL3 -6159
B4GALT1 -6125
NOTCH3 -5144
NOTCH2 -5057
LFNG -4880
NOTCH4 -3355
ATP2A2 -2559
ATP2A1 -2334
SEL1L 4617
RAB6A 8257
ST3GAL6 9285
TMED2 9346


Constitutive Signaling by NOTCH1 HD Domain Mutants

Constitutive Signaling by NOTCH1 HD Domain Mutants
211
set Constitutive Signaling by NOTCH1 HD Domain Mutants
setSize 14
pANOVA 0.0216
s.dist -0.355
p.adjustANOVA 0.131



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEURL1B -9789
RPS27A -8388
NOTCH1 -8307
UBA52 -7375
DLL1 -7224
MIB2 -6846
JAG1 -6208
UBB -4944
UBC -4177
MIB1 -2896
JAG2 96
NEURL1 3966
ADAM10 7907
ADAM17 8758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEURL1B -9789
RPS27A -8388
NOTCH1 -8307
UBA52 -7375
DLL1 -7224
MIB2 -6846
JAG1 -6208
UBB -4944
UBC -4177
MIB1 -2896
JAG2 96
NEURL1 3966
ADAM10 7907
ADAM17 8758


Signaling by NOTCH1 HD Domain Mutants in Cancer

Signaling by NOTCH1 HD Domain Mutants in Cancer
1113
set Signaling by NOTCH1 HD Domain Mutants in Cancer
setSize 14
pANOVA 0.0216
s.dist -0.355
p.adjustANOVA 0.131



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEURL1B -9789
RPS27A -8388
NOTCH1 -8307
UBA52 -7375
DLL1 -7224
MIB2 -6846
JAG1 -6208
UBB -4944
UBC -4177
MIB1 -2896
JAG2 96
NEURL1 3966
ADAM10 7907
ADAM17 8758

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEURL1B -9789
RPS27A -8388
NOTCH1 -8307
UBA52 -7375
DLL1 -7224
MIB2 -6846
JAG1 -6208
UBB -4944
UBC -4177
MIB1 -2896
JAG2 96
NEURL1 3966
ADAM10 7907
ADAM17 8758


HDR through Single Strand Annealing (SSA)

HDR through Single Strand Annealing (SSA)
482
set HDR through Single Strand Annealing (SSA)
setSize 37
pANOVA 0.000189
s.dist 0.355
p.adjustANOVA 0.00403



Top enriched genes

Top 20 genes
GeneID Gene Rank
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
RAD17 9946
RFC4 9891
RAD9B 9234
HUS1 9132
BARD1 9023
TOPBP1 8826
BRCA1 8138
RFC3 7972
ERCC4 7215
BRIP1 6803
RAD1 6800
RAD51 6337
RPA2 5538
ATR 4908

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RBBP8 11241
RMI1 11215
RMI2 11085
NBN 10610
RAD50 10371
DNA2 9957
RAD17 9946
RFC4 9891
RAD9B 9234
HUS1 9132
BARD1 9023
TOPBP1 8826
BRCA1 8138
RFC3 7972
ERCC4 7215
BRIP1 6803
RAD1 6800
RAD51 6337
RPA2 5538
ATR 4908
BLM 4120
WRN 4117
RHNO1 3076
EXO1 2398
RPA3 2293
ATRIP 2287
MRE11 2275
RAD52 2122
RFC5 919
KAT5 -301
RFC2 -697
ATM -768
RAD9A -1761
TOP3A -2746
RPA1 -4771
ABL1 -7441
ERCC1 -9432


p75NTR recruits signalling complexes

p75NTR recruits signalling complexes
1353
set p75NTR recruits signalling complexes
setSize 12
pANOVA 0.0354
s.dist -0.351
p.adjustANOVA 0.183



Top enriched genes

Top 20 genes
GeneID Gene Rank
IRAK1 -9487
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
IKBKB -4462
UBC -4177
NGFR -2692
RIPK2 156
TRAF6 2326
MYD88 4098
PRKCI 4288

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
IRAK1 -9487
RPS27A -8388
SQSTM1 -7746
UBA52 -7375
UBB -4944
IKBKB -4462
UBC -4177
NGFR -2692
RIPK2 156
TRAF6 2326
MYD88 4098
PRKCI 4288


RMTs methylate histone arginines

RMTs methylate histone arginines
899
set RMTs methylate histone arginines
setSize 37
pANOVA 0.000231
s.dist -0.35
p.adjustANOVA 0.00468



Top enriched genes

Top 20 genes
GeneID Gene Rank
RPS2 -10243.0
H2AZ1 -8776.0
DNMT3A -8681.0
PRMT7 -8305.0
SMARCA4 -8195.0
PRMT1 -8163.0
CARM1 -8103.0
H3C15 -8038.5
ARID1B -7820.0
H2AJ -7536.0
SMARCD2 -6959.0
PRMT6 -6823.0
SMARCA2 -6736.0
H2AW -6266.0
ARID1A -5907.0
CDK4 -5841.0
CCND1 -5765.0
WDR5 -5526.0
SMARCD3 -5169.0
H2AC6 -4383.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
RPS2 -10243.0
H2AZ1 -8776.0
DNMT3A -8681.0
PRMT7 -8305.0
SMARCA4 -8195.0
PRMT1 -8163.0
CARM1 -8103.0
H3C15 -8038.5
ARID1B -7820.0
H2AJ -7536.0
SMARCD2 -6959.0
PRMT6 -6823.0
SMARCA2 -6736.0
H2AW -6266.0
ARID1A -5907.0
CDK4 -5841.0
CCND1 -5765.0
WDR5 -5526.0
SMARCD3 -5169.0
H2AC6 -4383.0
SMARCE1 -3958.0
H2AC11 -3957.0
SMARCC2 -3632.0
SMARCC1 -2907.0
COPRS -2686.0
H2AZ2 -2475.0
SMARCD1 -1501.0
SMARCB1 -1331.0
PRMT5 1982.0
ARID2 2546.0
WDR77 2958.0
H2AC20 3907.0
PBRM1 4182.0
RBBP7 4858.0
ACTL6A 5304.0
PRMT3 10740.0
JAK2 11299.0


Heparan sulfate/heparin (HS-GAG) metabolism

Heparan sulfate/heparin (HS-GAG) metabolism
499
set Heparan sulfate/heparin (HS-GAG) metabolism
setSize 38
pANOVA 0.000232
s.dist -0.345
p.adjustANOVA 0.00468



Top enriched genes

Top 20 genes
GeneID Gene Rank
SGSH -10002
B3GAT3 -9818
NAGLU -9725
XYLT1 -9723
GPC4 -9454
B3GALT6 -8920
XYLT2 -8645
HS3ST3A1 -8515
HS6ST1 -8243
B4GALT7 -8207
GPC1 -8099
GPC2 -7735
GUSB -5871
NDST1 -5681
HSPG2 -5458
IDS -5405
NDST2 -4937
CSPG4 -4429
IDUA -4267
HPSE -2954

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SGSH -10002
B3GAT3 -9818
NAGLU -9725
XYLT1 -9723
GPC4 -9454
B3GALT6 -8920
XYLT2 -8645
HS3ST3A1 -8515
HS6ST1 -8243
B4GALT7 -8207
GPC1 -8099
GPC2 -7735
GUSB -5871
NDST1 -5681
HSPG2 -5458
IDS -5405
NDST2 -4937
CSPG4 -4429
IDUA -4267
HPSE -2954
B3GAT2 -1900
HS3ST1 -1780
HS3ST3B1 -1489
EXT2 -1446
SDC4 -1368
B3GAT1 18
GLB1L 62
HS2ST1 1340
SDC3 1680
VCAN 1854
GLB1 2354
GLCE 2404
HS3ST2 2578
DCN 2926
SDC2 3889
SLC35D2 4601
EXT1 5091
AGRN 6202


Regulation of IFNG signaling

Regulation of IFNG signaling
958
set Regulation of IFNG signaling
setSize 14
pANOVA 0.0255
s.dist 0.345
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
PIAS1 11651
JAK2 11299
IFNG 11066
SUMO1 10348
STAT1 9925
IFNGR1 9252
SOCS1 8886
IFNGR2 7797
PTPN2 7592
PTPN11 -619
PTPN6 -2890
PTPN1 -2967
JAK1 -8196
SOCS3 -10318

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PIAS1 11651
JAK2 11299
IFNG 11066
SUMO1 10348
STAT1 9925
IFNGR1 9252
SOCS1 8886
IFNGR2 7797
PTPN2 7592
PTPN11 -619
PTPN6 -2890
PTPN1 -2967
JAK1 -8196
SOCS3 -10318


Synthesis of PIPs at the late endosome membrane

Synthesis of PIPs at the late endosome membrane
1175
set Synthesis of PIPs at the late endosome membrane
setSize 11
pANOVA 0.0479
s.dist 0.344
p.adjustANOVA 0.219



Top enriched genes

Top 20 genes
GeneID Gene Rank
MTM1 11112
FIG4 8956
MTMR9 8405
PIK3C2A 8129
PIK3C3 7079
PIK3R4 5876
MTMR7 5356
MTMR2 3647
PIKFYVE 2542
MTMR4 -2215
VAC14 -9559

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MTM1 11112
FIG4 8956
MTMR9 8405
PIK3C2A 8129
PIK3C3 7079
PIK3R4 5876
MTMR7 5356
MTMR2 3647
PIKFYVE 2542
MTMR4 -2215
VAC14 -9559


Collagen chain trimerization

Collagen chain trimerization
198
set Collagen chain trimerization
setSize 27
pANOVA 0.00198
s.dist -0.344
p.adjustANOVA 0.0276



Top enriched genes

Top 20 genes
GeneID Gene Rank
COL13A1 -10378
COL5A1 -10274
COL8A2 -9359
COL26A1 -9085
COL7A1 -8954
COL27A1 -8272
COL5A3 -7982
COL24A1 -7193
COL6A1 -7192
COL11A2 -6500
COL18A1 -6216
COL5A2 -5813
COL6A2 -5676
COL28A1 -4958
COL10A1 -4755
COL15A1 -4732
COL17A1 -3908
COL19A1 -3023
COL23A1 -1246
COL4A2 917

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
COL13A1 -10378
COL5A1 -10274
COL8A2 -9359
COL26A1 -9085
COL7A1 -8954
COL27A1 -8272
COL5A3 -7982
COL24A1 -7193
COL6A1 -7192
COL11A2 -6500
COL18A1 -6216
COL5A2 -5813
COL6A2 -5676
COL28A1 -4958
COL10A1 -4755
COL15A1 -4732
COL17A1 -3908
COL19A1 -3023
COL23A1 -1246
COL4A2 917
COL4A3 1778
COL4A4 3285
COL9A3 3915
COL9A2 4540
COL8A1 8161
COL1A2 8984
COL6A3 9600


Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
32
set Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
setSize 22
pANOVA 0.00533
s.dist -0.343
p.adjustANOVA 0.0516



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AZ1 -8776.0
H2BC12 -8742.0
PKN1 -8565.0
H2BC17 -8346.0
H3C15 -8038.5
H2BC4 -7928.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
H2BC15 -4416.0
H2AC6 -4383.0
H2BC5 -3070.0
H2AZ2 -2475.0
AR -366.0
NCOA2 1439.0
KDM1A 2200.0
KDM4C 2529.0
H2BU1 2721.0
H2AC20 3907.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AZ1 -8776.0
H2BC12 -8742.0
PKN1 -8565.0
H2BC17 -8346.0
H3C15 -8038.5
H2BC4 -7928.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
H2BC15 -4416.0
H2AC6 -4383.0
H2BC5 -3070.0
H2AZ2 -2475.0
AR -366.0
NCOA2 1439.0
KDM1A 2200.0
KDM4C 2529.0
H2BU1 2721.0
H2AC20 3907.0
KLK2 4164.0
H3-3A 5193.0


Plasma lipoprotein clearance

Plasma lipoprotein clearance
827
set Plasma lipoprotein clearance
setSize 29
pANOVA 0.00147
s.dist -0.341
p.adjustANOVA 0.0234



Top enriched genes

Top 20 genes
GeneID Gene Rank
SCARB1 -9861
NR1H2 -9025
AP2M1 -8930
APOE -8186
APOBR -7903
AP2A2 -7814
AP2A1 -6826
LSR -6787
CES3 -6277
CUBN -5579
LIPC -4960
NR1H3 -4903
MYLIP -4778
AMN -4299
NPC1 -4273
VLDLR -4257
AP2S1 -3863
AP2B1 -3395
LIPA -3104
APOC4 -2383

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SCARB1 -9861
NR1H2 -9025
AP2M1 -8930
APOE -8186
APOBR -7903
AP2A2 -7814
AP2A1 -6826
LSR -6787
CES3 -6277
CUBN -5579
LIPC -4960
NR1H3 -4903
MYLIP -4778
AMN -4299
NPC1 -4273
VLDLR -4257
AP2S1 -3863
AP2B1 -3395
LIPA -3104
APOC4 -2383
LDLRAP1 -1661
CLTA 509
CLTC 1283
HDLBP 2104
NCEH1 3162
SOAT1 4111
LDLR 4250
NPC2 6507
SOAT2 7476


IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)
515
set IRAK4 deficiency (TLR2/4)
setSize 10
pANOVA 0.0621
s.dist 0.341
p.adjustANOVA 0.256



Top enriched genes

Top 20 genes
GeneID Gene Rank
TLR2 10184
CD36 9777
BTK 9179
LY96 7947
TLR1 7591
MYD88 4098
TLR6 3066
TLR4 1481
TIRAP -3612
CD14 -5276

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 10184
CD36 9777
BTK 9179
LY96 7947
TLR1 7591
MYD88 4098
TLR6 3066
TLR4 1481
TIRAP -3612
CD14 -5276


MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)
688
set MyD88 deficiency (TLR2/4)
setSize 10
pANOVA 0.0621
s.dist 0.341
p.adjustANOVA 0.256



Top enriched genes

Top 20 genes
GeneID Gene Rank
TLR2 10184
CD36 9777
BTK 9179
LY96 7947
TLR1 7591
MYD88 4098
TLR6 3066
TLR4 1481
TIRAP -3612
CD14 -5276

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
TLR2 10184
CD36 9777
BTK 9179
LY96 7947
TLR1 7591
MYD88 4098
TLR6 3066
TLR4 1481
TIRAP -3612
CD14 -5276


Constitutive Signaling by AKT1 E17K in Cancer

Constitutive Signaling by AKT1 E17K in Cancer
207
set Constitutive Signaling by AKT1 E17K in Cancer
setSize 26
pANOVA 0.0027
s.dist -0.34
p.adjustANOVA 0.0338



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKT2 -10102
AKT1S1 -10026
FOXO4 -9911
AKT1 -9799
PRR5 -9351
BAD -9119
MTOR -8632
FOXO1 -8143
PDPK1 -7616
TSC2 -7121
FOXO3 -7061
FOXO6 -6422
MLST8 -6381
RPS6KB2 -6218
GSK3A -5827
CDKN1B -1307
GSK3B -223
CASP9 286
NR4A1 2131
AKT3 2465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKT2 -10102
AKT1S1 -10026
FOXO4 -9911
AKT1 -9799
PRR5 -9351
BAD -9119
MTOR -8632
FOXO1 -8143
PDPK1 -7616
TSC2 -7121
FOXO3 -7061
FOXO6 -6422
MLST8 -6381
RPS6KB2 -6218
GSK3A -5827
CDKN1B -1307
GSK3B -223
CASP9 286
NR4A1 2131
AKT3 2465
MAPKAP1 3210
CDKN1A 3342
CREB1 6457
RICTOR 6758
CHUK 7378
MDM2 11204


Regulation of localization of FOXO transcription factors

Regulation of localization of FOXO transcription factors
989
set Regulation of localization of FOXO transcription factors
setSize 12
pANOVA 0.0448
s.dist -0.335
p.adjustANOVA 0.21



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKT2 -10102
FOXO4 -9911
AKT1 -9799
FOXO1 -8143
FOXO3 -7061
SFN -6586
FOXO6 -6422
YWHAG -3999
AKT3 2465
YWHAQ 2580
YWHAZ 9618
YWHAB 11092

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKT2 -10102
FOXO4 -9911
AKT1 -9799
FOXO1 -8143
FOXO3 -7061
SFN -6586
FOXO6 -6422
YWHAG -3999
AKT3 2465
YWHAQ 2580
YWHAZ 9618
YWHAB 11092


Retrograde neurotrophin signalling

Retrograde neurotrophin signalling
1014
set Retrograde neurotrophin signalling
setSize 12
pANOVA 0.0465
s.dist -0.332
p.adjustANOVA 0.216



Top enriched genes

Top 20 genes
GeneID Gene Rank
DNM2 -9367
DNAL4 -9030
AP2M1 -8930
AP2A2 -7814
AP2A1 -6826
AP2S1 -3863
AP2B1 -3395
DNM3 -1395
CLTA 509
CLTC 1283
NTRK1 5106
DNM1 7802

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
DNM2 -9367
DNAL4 -9030
AP2M1 -8930
AP2A2 -7814
AP2A1 -6826
AP2S1 -3863
AP2B1 -3395
DNM3 -1395
CLTA 509
CLTC 1283
NTRK1 5106
DNM1 7802


Lewis blood group biosynthesis

Lewis blood group biosynthesis
602
set Lewis blood group biosynthesis
setSize 13
pANOVA 0.0389
s.dist -0.331
p.adjustANOVA 0.192



Top enriched genes

Top 20 genes
GeneID Gene Rank
B3GALT2 -10110
FUT7 -9983
ST3GAL4 -9287
ST3GAL3 -6159
B3GALT4 -5604
B4GALNT2 -5330
FUT4 -4894
ST6GALNAC6 -2666
FUT2 -252
FUT10 1123
FUT11 1230
B3GALT1 3901
ST3GAL6 9285

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3GALT2 -10110
FUT7 -9983
ST3GAL4 -9287
ST3GAL3 -6159
B3GALT4 -5604
B4GALNT2 -5330
FUT4 -4894
ST6GALNAC6 -2666
FUT2 -252
FUT10 1123
FUT11 1230
B3GALT1 3901
ST3GAL6 9285


Cleavage of the damaged purine

Cleavage of the damaged purine
193
set Cleavage of the damaged purine
setSize 24
pANOVA 0.0052
s.dist -0.329
p.adjustANOVA 0.0512



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
MUTYH -7969
H2BC4 -7928
MPG -7571
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
OGG1 -1535
H2BU1 2721
H2AC20 3907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
MUTYH -7969
H2BC4 -7928
MPG -7571
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
OGG1 -1535
H2BU1 2721
H2AC20 3907
NEIL3 3946
TERF2 4874
TERF1 8885
POT1 10140


Depurination

Depurination
277
set Depurination
setSize 24
pANOVA 0.0052
s.dist -0.329
p.adjustANOVA 0.0512



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
MUTYH -7969
H2BC4 -7928
MPG -7571
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
OGG1 -1535
H2BU1 2721
H2AC20 3907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
MUTYH -7969
H2BC4 -7928
MPG -7571
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
OGG1 -1535
H2BU1 2721
H2AC20 3907
NEIL3 3946
TERF2 4874
TERF1 8885
POT1 10140


Recognition and association of DNA glycosylase with site containing an affected purine

Recognition and association of DNA glycosylase with site containing an affected purine
940
set Recognition and association of DNA glycosylase with site containing an affected purine
setSize 24
pANOVA 0.0052
s.dist -0.329
p.adjustANOVA 0.0512



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
MUTYH -7969
H2BC4 -7928
MPG -7571
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
OGG1 -1535
H2BU1 2721
H2AC20 3907

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
MUTYH -7969
H2BC4 -7928
MPG -7571
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
OGG1 -1535
H2BU1 2721
H2AC20 3907
NEIL3 3946
TERF2 4874
TERF1 8885
POT1 10140


NOTCH3 Activation and Transmission of Signal to the Nucleus

NOTCH3 Activation and Transmission of Signal to the Nucleus
707
set NOTCH3 Activation and Transmission of Signal to the Nucleus
setSize 23
pANOVA 0.00629
s.dist -0.329
p.adjustANOVA 0.0577



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEURL1B -9789
PSEN2 -8735
TACC3 -8710
RPS27A -8388
APH1A -8076
UBA52 -7375
DLL1 -7224
MIB2 -6846
JAG1 -6208
NOTCH3 -5144
UBB -4944
YBX1 -4896
WWP2 -4221
UBC -4177
MIB1 -2896
PSENEN -1485
JAG2 96
EGF 514
NEURL1 3966
NCSTN 4145

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEURL1B -9789
PSEN2 -8735
TACC3 -8710
RPS27A -8388
APH1A -8076
UBA52 -7375
DLL1 -7224
MIB2 -6846
JAG1 -6208
NOTCH3 -5144
UBB -4944
YBX1 -4896
WWP2 -4221
UBC -4177
MIB1 -2896
PSENEN -1485
JAG2 96
EGF 514
NEURL1 3966
NCSTN 4145
PSEN1 5605
ADAM10 7907
APH1B 8804


Biosynthesis of DHA-derived SPMs

Biosynthesis of DHA-derived SPMs
111
set Biosynthesis of DHA-derived SPMs
setSize 14
pANOVA 0.0336
s.dist -0.328
p.adjustANOVA 0.179



Top enriched genes

Top 20 genes
GeneID Gene Rank
PTGS2 -10227
ALOX15 -10146
CYP2D6 -9540
CYP2E1 -8914
LTC4S -8566
GSTM4 -5489
ALOX12 -3352
EPHX2 -3039
GPX4 -2653
CYP2C9 -93
ALOX5 932
HPGD 4018
LTA4H 5996
CYP1A2 9770

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PTGS2 -10227
ALOX15 -10146
CYP2D6 -9540
CYP2E1 -8914
LTC4S -8566
GSTM4 -5489
ALOX12 -3352
EPHX2 -3039
GPX4 -2653
CYP2C9 -93
ALOX5 932
HPGD 4018
LTA4H 5996
CYP1A2 9770


Chondroitin sulfate/dermatan sulfate metabolism

Chondroitin sulfate/dermatan sulfate metabolism
179
set Chondroitin sulfate/dermatan sulfate metabolism
setSize 39
pANOVA 0.000415
s.dist -0.327
p.adjustANOVA 0.00737



Top enriched genes

Top 20 genes
GeneID Gene Rank
UST -10325
B3GAT3 -9818
XYLT1 -9723
GPC4 -9454
B3GALT6 -8920
CHST13 -8851
XYLT2 -8645
CHPF2 -8533
B4GALT7 -8207
GPC1 -8099
CHST14 -7842
GPC2 -7735
HYAL3 -7583
CHST7 -7467
CHPF -7214
CHST11 -6832
HSPG2 -5458
IDS -5405
CSPG4 -4429
IDUA -4267

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
UST -10325
B3GAT3 -9818
XYLT1 -9723
GPC4 -9454
B3GALT6 -8920
CHST13 -8851
XYLT2 -8645
CHPF2 -8533
B4GALT7 -8207
GPC1 -8099
CHST14 -7842
GPC2 -7735
HYAL3 -7583
CHST7 -7467
CHPF -7214
CHST11 -6832
HSPG2 -5458
IDS -5405
CSPG4 -4429
IDUA -4267
HEXA -4137
CHSY1 -3078
CSGALNACT1 -2785
B3GAT2 -1900
SDC4 -1368
CHST12 -1069
B3GAT1 18
CHST15 1540
SDC3 1680
VCAN 1854
DCN 2926
DSE 3281
ARSB 3778
SDC2 3889
HEXB 4049
AGRN 6202
HYAL1 6747
DSEL 8172
CSGALNACT2 10728


Common Pathway of Fibrin Clot Formation

Common Pathway of Fibrin Clot Formation
201
set Common Pathway of Fibrin Clot Formation
setSize 14
pANOVA 0.0359
s.dist -0.324
p.adjustANOVA 0.184



Top enriched genes

Top 20 genes
GeneID Gene Rank
PRTN3 -10161
CD177 -9288
PF4 -8535
PROCR -7828
F13A1 -7712
PF4V1 -5752
PROC -5663
THBD -5008
PROS1 -2517
SERPINE2 1211
F2R 1412
F5 4372
F8 6093
SERPIND1 8734

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
PRTN3 -10161
CD177 -9288
PF4 -8535
PROCR -7828
F13A1 -7712
PF4V1 -5752
PROC -5663
THBD -5008
PROS1 -2517
SERPINE2 1211
F2R 1412
F5 4372
F8 6093
SERPIND1 8734


Packaging Of Telomere Ends

Packaging Of Telomere Ends
804
set Packaging Of Telomere Ends
setSize 20
pANOVA 0.0122
s.dist -0.324
p.adjustANOVA 0.0874



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
H2BC4 -7928
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
H2BU1 2721
H2AC20 3907
TERF2 4874
TERF1 8885
POT1 10140

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2AZ1 -8776
H2BC12 -8742
H2BC17 -8346
H2BC4 -7928
H2AJ -7536
H2BC9 -6894
ACD -6691
H2BC11 -5751
H2BC21 -5415
TINF2 -4662
H2BC15 -4416
H2AC6 -4383
TERF2IP -3454
H2BC5 -3070
H2AZ2 -2475
H2BU1 2721
H2AC20 3907
TERF2 4874
TERF1 8885
POT1 10140


Downregulation of ERBB2:ERBB3 signaling

Downregulation of ERBB2:ERBB3 signaling
306
set Downregulation of ERBB2:ERBB3 signaling
setSize 12
pANOVA 0.0533
s.dist -0.322
p.adjustANOVA 0.235



Top enriched genes

Top 20 genes
GeneID Gene Rank
AKT2 -10102
AKT1 -9799
ERBB2 -8564
RPS27A -8388
UBA52 -7375
UBB -4944
UBC -4177
NRG1 -1293
RNF41 -1156
AKT3 2465
ERBB3 7160
USP8 11545

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AKT2 -10102
AKT1 -9799
ERBB2 -8564
RPS27A -8388
UBA52 -7375
UBB -4944
UBC -4177
NRG1 -1293
RNF41 -1156
AKT3 2465
ERBB3 7160
USP8 11545


HIV elongation arrest and recovery

HIV elongation arrest and recovery
487
set HIV elongation arrest and recovery
setSize 32
pANOVA 0.00164
s.dist -0.322
p.adjustANOVA 0.0247



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998
NELFE -2081
ELOC 1200
SUPT4H1 1271
SUPT16H 2912
ELOA 2983
POLR2D 4912
CCNK 5104
GTF2F2 5332
POLR2B 7601
CCNT2 8285
TCEA1 8287
POLR2K 9927


Pausing and recovery of HIV elongation

Pausing and recovery of HIV elongation
807
set Pausing and recovery of HIV elongation
setSize 32
pANOVA 0.00164
s.dist -0.322
p.adjustANOVA 0.0247



Top enriched genes

Top 20 genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
POLR2L -10282
CDK9 -10180
CTDP1 -9955
NELFB -9862
GTF2F1 -9355
POLR2I -9194
POLR2F -9158
POLR2E -9034
ELL -8355
ELOB -8164
POLR2G -8006
SUPT5H -7930
POLR2A -6255
POLR2J -5993
SSRP1 -5218
NELFA -5007
POLR2H -4752
NELFCD -4629
CCNT1 -3403
POLR2C -2998
NELFE -2081
ELOC 1200
SUPT4H1 1271
SUPT16H 2912
ELOA 2983
POLR2D 4912
CCNK 5104
GTF2F2 5332
POLR2B 7601
CCNT2 8285
TCEA1 8287
POLR2K 9927


NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus
705
set NOTCH2 Activation and Transmission of Signal to the Nucleus
setSize 20
pANOVA 0.0133
s.dist -0.32
p.adjustANOVA 0.0912



Top enriched genes

Top 20 genes
GeneID Gene Rank
NEURL1B -9789
PSEN2 -8735
RPS27A -8388
APH1A -8076
UBA52 -7375
DLL1 -7224
MIB2 -6846
MDK -6468
JAG1 -6208
NOTCH2 -5057
UBB -4944
UBC -4177
MIB1 -2896
PSENEN -1485
JAG2 96
NEURL1 3966
NCSTN 4145
PSEN1 5605
ADAM10 7907
APH1B 8804

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
NEURL1B -9789
PSEN2 -8735
RPS27A -8388
APH1A -8076
UBA52 -7375
DLL1 -7224
MIB2 -6846
MDK -6468
JAG1 -6208
NOTCH2 -5057
UBB -4944
UBC -4177
MIB1 -2896
PSENEN -1485
JAG2 96
NEURL1 3966
NCSTN 4145
PSEN1 5605
ADAM10 7907
APH1B 8804


NGF-stimulated transcription

NGF-stimulated transcription
701
set NGF-stimulated transcription
setSize 33
pANOVA 0.00149
s.dist -0.32
p.adjustANOVA 0.0234



Top enriched genes

Top 20 genes
GeneID Gene Rank
FOSB -10380
EGR2 -10349
EGR1 -10288
SGK1 -10263
FOS -9975
JUND -9967
ID1 -9733
MEF2D -9627
JUNB -9564
DNM2 -9367
TRIB1 -8748
EGR3 -8231
ELK1 -7817
SRF -7749
CDK5R1 -5195
LYL1 -5089
ARC -5010
CHD4 -4423
RRAD -3005
EP300 -2667

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
FOSB -10380
EGR2 -10349
EGR1 -10288
SGK1 -10263
FOS -9975
JUND -9967
ID1 -9733
MEF2D -9627
JUNB -9564
DNM2 -9367
TRIB1 -8748
EGR3 -8231
ELK1 -7817
SRF -7749
CDK5R1 -5195
LYL1 -5089
ARC -5010
CHD4 -4423
RRAD -3005
EP300 -2667
NAB2 -2510
TCF12 -482
CDK5 -342
ID3 2031
FOSL1 3109
TF 3982
REST 5083
CREB1 6457
ID2 6591
TPH1 7055
NAB1 9587
ATF2 11312
ATF1 11420


EGFR downregulation

EGFR downregulation
321
set EGFR downregulation
setSize 27
pANOVA 0.00423
s.dist -0.318
p.adjustANOVA 0.0463



Top enriched genes

Top 20 genes
GeneID Gene Rank
ARHGEF7 -10122
EPN1 -8948
PTPRK -8514
HBEGF -8469
SH3GL1 -8459
AREG -8418
RPS27A -8388
SPRY1 -7724
EREG -7409
UBA52 -7375
EPS15L1 -6954
SPRY2 -6106
PTPN3 -5217
TGFA -5162
UBB -4944
UBC -4177
CBL -2683
HGS -1976
GRB2 75
EGF 514

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
ARHGEF7 -10122
EPN1 -8948
PTPRK -8514
HBEGF -8469
SH3GL1 -8459
AREG -8418
RPS27A -8388
SPRY1 -7724
EREG -7409
UBA52 -7375
EPS15L1 -6954
SPRY2 -6106
PTPN3 -5217
TGFA -5162
UBB -4944
UBC -4177
CBL -2683
HGS -1976
GRB2 75
EGF 514
PTPN12 1657
SH3KBP1 3420
EPGN 3595
STAM 3859
CDC42 9019
STAM2 10760
EPS15 11556


ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression

ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
332
set ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
setSize 32
pANOVA 0.00194
s.dist -0.317
p.adjustANOVA 0.0273



Top enriched genes

Top 20 genes
GeneID Gene Rank
EHMT2 -9644.0
MBD3 -9418.0
MTA1 -9323.0
CHD3 -8886.0
H2AZ1 -8776.0
H2BC12 -8742.0
H2BC17 -8346.0
GATAD2A -8189.0
H3C15 -8038.5
H2BC4 -7928.0
ERCC6 -7792.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
CHD4 -4423.0
H2BC15 -4416.0
H2AC6 -4383.0
MTA2 -4303.0
MTA3 -3076.0

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
EHMT2 -9644.0
MBD3 -9418.0
MTA1 -9323.0
CHD3 -8886.0
H2AZ1 -8776.0
H2BC12 -8742.0
H2BC17 -8346.0
GATAD2A -8189.0
H3C15 -8038.5
H2BC4 -7928.0
ERCC6 -7792.0
H2AJ -7536.0
H2BC9 -6894.0
H2BC11 -5751.0
H2BC21 -5415.0
CHD4 -4423.0
H2BC15 -4416.0
H2AC6 -4383.0
MTA2 -4303.0
MTA3 -3076.0
H2BC5 -3070.0
H2AZ2 -2475.0
GATAD2B 1694.0
H2BU1 2721.0
H2AC20 3907.0
HDAC1 4414.0
RBBP7 4858.0
H3-3A 5193.0
RBBP4 6165.0
HDAC2 6675.0
TTF1 10139.0
CBX3 10802.0


Cyclin A/B1/B2 associated events during G2/M transition

Cyclin A/B1/B2 associated events during G2/M transition
222
set Cyclin A/B1/B2 associated events during G2/M transition
setSize 24
pANOVA 0.00749
s.dist 0.315
p.adjustANOVA 0.064



Top enriched genes

Top 20 genes
GeneID Gene Rank
CCNA1 11725
PPP2R2A 11691
XPO1 11455
CCNH 11324
CDK7 10265
CDK1 9135
PPP2CB 8622
FOXM1 6055
CCNB1 5971
PPP2CA 5682
CCNB2 5588
MNAT1 5358
CCNA2 4976
WEE1 4830
PPP2R1B 3643
CDK2 2315
PPME1 2078
LCMT1 1586
PKMYT1 927
CDC25B -11

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
CCNA1 11725
PPP2R2A 11691
XPO1 11455
CCNH 11324
CDK7 10265
CDK1 9135
PPP2CB 8622
FOXM1 6055
CCNB1 5971
PPP2CA 5682
CCNB2 5588
MNAT1 5358
CCNA2 4976
WEE1 4830
PPP2R1B 3643
CDK2 2315
PPME1 2078
LCMT1 1586
PKMYT1 927
CDC25B -11
PLK1 -2414
CDC25A -3555
PPP2R1A -7631
PPP2R3B -9759


Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
718
set Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
setSize 21
pANOVA 0.013
s.dist -0.313
p.adjustANOVA 0.0895



Top enriched genes

Top 20 genes
GeneID Gene Rank
AP1M1 -9320
HLA-A -9057
AP2M1 -8930
AP1B1 -8263
ARF1 -8086
AP2A2 -7814
CD28 -7250
PACS1 -7044
AP1M2 -6981
AP2A1 -6826
LCK -4371
AP2S1 -3863
AP2B1 -3395
CD4 -1298
AP1S1 -931
AP1S3 2474
CD8B 3054
AP1G1 4301
ATP6V1H 5572
B2M 9465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
AP1M1 -9320
HLA-A -9057
AP2M1 -8930
AP1B1 -8263
ARF1 -8086
AP2A2 -7814
CD28 -7250
PACS1 -7044
AP1M2 -6981
AP2A1 -6826
LCK -4371
AP2S1 -3863
AP2B1 -3395
CD4 -1298
AP1S1 -931
AP1S3 2474
CD8B 3054
AP1G1 4301
ATP6V1H 5572
B2M 9465
AP1S2 10082


Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling
387
set Formation of ATP by chemiosmotic coupling
setSize 18
pANOVA 0.0216
s.dist -0.313
p.adjustANOVA 0.131



Top enriched genes

Top 20 genes
GeneID Gene Rank
MT-ATP8 -10332
ATP5ME -9874
MT-ATP6 -9606
ATP5F1D -9424
ATP5MG -8771
ATP5MF -8024
ATP5MC2 -7490
ATP5MC3 -4398
ATP5F1A -4172
ATP5F1E -3220
ATP5F1B -2212
ATP5PB 704
ATP5MC1 1413
ATP5PF 2504
ATP5PO 3036
ATP5PD 5191
ATP5F1C 5198
DMAC2L 9430

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
MT-ATP8 -10332
ATP5ME -9874
MT-ATP6 -9606
ATP5F1D -9424
ATP5MG -8771
ATP5MF -8024
ATP5MC2 -7490
ATP5MC3 -4398
ATP5F1A -4172
ATP5F1E -3220
ATP5F1B -2212
ATP5PB 704
ATP5MC1 1413
ATP5PF 2504
ATP5PO 3036
ATP5PD 5191
ATP5F1C 5198
DMAC2L 9430


Influenza Infection

Influenza Infection
529
set Influenza Infection
setSize 154
pANOVA 2.27e-11
s.dist -0.312
p.adjustANOVA 1.41e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
SLC25A6 -10385
RPL37 -10308
POLR2L -10282
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
POM121C -9374
GTF2F1 -9355
FAU -9334
RPS18 -9321

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
SLC25A6 -10385
RPL37 -10308
POLR2L -10282
RPS2 -10243
RPLP2 -10185
RPS29 -10049
RPS17 -9962
RPL36 -9899
RPL3 -9867
RPL8 -9738
RPL38 -9692
RPS16 -9633
RPS21 -9530
RPLP1 -9501
RPS4Y1 -9458
RPS12 -9407
POM121C -9374
GTF2F1 -9355
FAU -9334
RPS18 -9321
RPS27 -9308
RPL36AL -9271
RPS10 -9222
POLR2I -9194
POLR2F -9158
RPS5 -9130
NUP210 -9099
POLR2E -9034
RPLP0 -9032
RPL27A -9016
RPL7A -8955
RPS28 -8941
POM121 -8910
RPL35 -8896
RPL29 -8882
RPL37A -8844
RPS19 -8814
RPL18A -8789
RPL10 -8752
RPL27 -8691
RPS11 -8677
RPS3 -8434
RPS27A -8388
RPL39 -8259
RPL31 -8234
RPL41 -8197
RPS14 -8173
TGFB1 -8091
RPL32 -8070
CPSF4 -8008
POLR2G -8006
HSPA1A -7940
RPS15A -7835
RPL30 -7798
RPL18 -7720
RPS23 -7714
RPS9 -7668
RPS15 -7663
RPL12 -7427
UBA52 -7375
RPS6 -7364
RPL17 -7051
RPL35A -6977
RPL15 -6926
RPL19 -6701
RPL7 -6643
RPL22 -6602
RPS7 -6568
RPL14 -6402
RPL21 -6288
POLR2A -6255
POLR2J -5993
RPL36A -5966
NUP188 -5843
RPL39L -5829
RPL4 -5814
RPL13 -5675
RPS25 -5670
RPL5 -5445
RPL26 -5374
RPL28 -5271
RPL13A -5249
RPL11 -5206
RPS13 -5170
PARP1 -4864
RPL10A -4820
PABPN1 -4813
POLR2H -4752
RPL23 -4456
RPL24 -3939
RPS26 -3701
SEC13 -3159
NUP62 -3119
RPS8 -3073
RPS20 -3024
POLR2C -2998
RPL9 -2451
RPL26L1 -2412
RPL34 -2254
IPO5 -1917
AAAS -1609
RPS24 -89
NDC1 -77
RPL23A 138
CLTA 509
CLTC 1283
RPL6 1290
RPS4X 1825
NUP214 2090
NUP98 2149
NUP93 3043
CALR 3069
NUP155 3103
RPS3A 3173
NUP160 3296
CANX 3437
NUP205 3520
NUP153 3654
NUP37 3973
GRSF1 4059
NUP88 4512
POLR2D 4912
TPR 4956
RAN 5082
RPSA 5249
GTF2F2 5332
NUP133 5417
RANBP2 5691
RAE1 6124
KPNA2 6216
NUP85 6578
NUP58 6817
NUP50 7082
KPNB1 7251
POLR2B 7601
DNAJC3 7755
NUP107 7988
KPNA1 8096
RPL22L1 8317
HSP90AA1 8431
NUP35 8941
RPL3L 8978
KPNA3 9027
RPS27L 9625
ISG15 9822
SEH1L 9849
KPNA4 9875
POLR2K 9927
KPNA5 9958
NUP43 10569
NUP42 10900
XPO1 11455
NUP54 11540
EIF2AK2 11688


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0               GGally_2.1.1               
##  [3] beeswarm_0.3.1              gtools_3.8.2               
##  [5] echarts4r_0.4.0             topconfects_1.6.0          
##  [7] limma_3.46.0                eulerr_6.1.0               
##  [9] mitch_1.2.2                 MASS_7.3-53.1              
## [11] fgsea_1.16.0                gplots_3.1.1               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.58.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] reshape2_1.4.4              forcats_0.5.1              
## [25] stringr_1.4.0               dplyr_1.0.5                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.3                 tibble_3.1.0               
## [31] ggplot2_3.3.3               tidyverse_1.3.0            
## [33] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_2.0.2       
##   [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.13       
##   [7] farver_2.1.0           bit64_4.0.5            AnnotationDbi_1.52.0  
##  [10] fansi_0.4.2            lubridate_1.7.10       xml2_1.3.2            
##  [13] splines_4.0.3          cachem_1.0.4           geneplotter_1.68.0    
##  [16] knitr_1.31             polyclip_1.10-0        jsonlite_1.7.2        
##  [19] broom_0.7.5            annotate_1.68.0        dbplyr_2.1.0          
##  [22] shiny_1.6.0            compiler_4.0.3         httr_1.4.2            
##  [25] backports_1.2.1        assertthat_0.2.1       Matrix_1.3-2          
##  [28] fastmap_1.1.0          cli_2.3.1              later_1.1.0.1         
##  [31] htmltools_0.5.1.1      tools_4.0.3            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
##  [37] Rcpp_1.0.6             cellranger_1.1.0       jquerylib_0.1.3       
##  [40] vctrs_0.3.6            polylabelr_0.2.0       xfun_0.22             
##  [43] ps_1.6.0               testthat_3.0.2         rvest_1.0.0           
##  [46] mime_0.10              lifecycle_1.0.0        XML_3.99-0.6          
##  [49] zlibbioc_1.36.0        scales_1.1.1           promises_1.2.0.1      
##  [52] hms_1.0.0              RColorBrewer_1.1-2     yaml_2.2.1            
##  [55] memoise_2.0.0          gridExtra_2.3          sass_0.3.1            
##  [58] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.4         
##  [61] highr_0.8              genefilter_1.72.0      desc_1.3.0            
##  [64] caTools_1.18.1         BiocParallel_1.24.1    rlang_0.4.10          
##  [67] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
##  [70] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.3     
##  [73] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
##  [76] magrittr_2.0.1         R6_2.5.0               generics_0.1.0        
##  [79] DelayedArray_0.16.0    DBI_1.1.1              pillar_1.5.1          
##  [82] haven_2.3.1            withr_2.4.1            survival_3.2-10       
##  [85] RCurl_1.98-1.3         modelr_0.1.8           crayon_1.4.1          
##  [88] KernSmooth_2.23-18     utf8_1.2.1             rmarkdown_2.7         
##  [91] locfit_1.5-9.4         grid_4.0.3             readxl_1.3.1          
##  [94] data.table_1.14.0      blob_1.2.1             reprex_1.0.0          
##  [97] digest_0.6.27          xtable_1.8-4           httpuv_1.5.5          
## [100] munsell_0.5.0          bslib_0.2.4

END of report