Mitch Report

date generated: 2021-04-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             low CRP   high CRP
## A1BG      1.3448650  1.7900749
## A1BG-AS1  0.6121583  0.2690665
## A1CF      0.3948857  0.1941578
## A2M      -1.2249521 -2.9774271
## A2M-AS1  -1.3083997 -2.2977591
## A2ML1    -0.7528612 -0.4068597

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	21404
duplicated_genes_present	0
num_profile_genes_in_sets	8378
num_profile_genes_not_in_sets	13026
profile_pearson_correl	0.64689
profile_spearman_correl	0.59772

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2408
num_genesets_excluded	1045
num_genesets_included	1363

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 586

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.low.CRP	s.high.CRP	p.low.CRP	p.high.CRP
IRAK4 deficiency (TLR2/4)	10	1.45e-06	9.18e-06	1.190	0.813	0.875	8.51e-06	1.65e-06
MyD88 deficiency (TLR2/4)	10	1.45e-06	9.18e-06	1.190	0.813	0.875	8.51e-06	1.65e-06
Regulation of TLR by endogenous ligand	11	4.26e-06	2.48e-05	1.090	0.798	0.746	4.59e-06	1.81e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	2.22e-06	1.37e-05	1.070	0.713	0.798	1.90e-05	1.69e-06
alpha-linolenic acid (ALA) metabolism	12	2.22e-06	1.37e-05	1.070	0.713	0.798	1.90e-05	1.69e-06
Translocation of ZAP-70 to Immunological synapse	24	2.61e-11	4.87e-10	0.987	-0.550	-0.819	3.10e-06	3.60e-12
Erythrocytes take up carbon dioxide and release oxygen	11	1.14e-04	4.96e-04	0.938	0.670	0.656	1.19e-04	1.64e-04
O2/CO2 exchange in erythrocytes	11	1.14e-04	4.96e-04	0.938	0.670	0.656	1.19e-04	1.64e-04
Hyaluronan uptake and degradation	12	6.18e-05	2.86e-04	0.900	0.537	0.722	1.29e-03	1.48e-05
Uptake and function of anthrax toxins	10	5.79e-04	2.15e-03	0.865	0.518	0.693	4.59e-03	1.47e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.17e-04	5.01e-04	0.842	0.403	0.739	2.06e-02	2.17e-05
Advanced glycosylation endproduct receptor signaling	12	2.06e-04	8.37e-04	0.841	0.501	0.676	2.65e-03	5.01e-05
p130Cas linkage to MAPK signaling for integrins	11	8.77e-04	3.11e-03	0.824	0.560	0.605	1.31e-03	5.14e-04
Detoxification of Reactive Oxygen Species	31	4.79e-09	4.60e-08	0.807	0.605	0.533	5.35e-09	2.73e-07
ROS and RNS production in phagocytes	31	4.57e-09	4.45e-08	0.806	0.610	0.528	4.14e-09	3.65e-07
Unwinding of DNA	12	4.92e-04	1.85e-03	0.804	-0.492	-0.635	3.17e-03	1.38e-04
Insulin receptor recycling	21	3.68e-06	2.16e-05	0.797	0.568	0.559	6.62e-06	9.21e-06
PD-1 signaling	28	2.29e-09	2.38e-08	0.781	-0.372	-0.687	6.63e-04	3.12e-10
Neutrophil degranulation	456	0.00e+00	0.00e+00	0.760	0.536	0.539	3.01e-86	2.42e-87
Phosphorylation of CD3 and TCR zeta chains	27	2.34e-07	1.73e-06	0.758	-0.463	-0.600	3.13e-05	6.63e-08
Dissolution of Fibrin Clot	12	1.32e-03	4.50e-03	0.756	0.479	0.585	4.08e-03	4.47e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.70e-03	5.57e-03	0.752	0.540	0.524	1.20e-03	1.67e-03
Golgi Cisternae Pericentriolar Stack Reorganization	14	6.29e-04	2.32e-03	0.749	0.519	0.540	7.78e-04	4.69e-04
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	4.88e-03	1.44e-02	0.743	0.471	0.574	9.91e-03	1.67e-03
HuR (ELAVL1) binds and stabilizes mRNA	10	5.50e-03	1.60e-02	0.730	0.573	0.452	1.70e-03	1.32e-02
Signaling by Leptin	10	6.91e-03	1.94e-02	0.728	0.523	0.507	4.21e-03	5.54e-03
COPI-independent Golgi-to-ER retrograde traffic	33	1.39e-08	1.23e-07	0.726	0.406	0.602	5.34e-05	2.14e-09
RHO GTPases Activate WASPs and WAVEs	35	1.28e-08	1.14e-07	0.720	0.425	0.580	1.32e-05	2.78e-09
RHO GTPases Activate NADPH Oxidases	21	4.40e-05	2.13e-04	0.706	0.453	0.541	3.24e-04	1.78e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	5.42e-04	2.04e-03	0.702	0.331	0.619	3.86e-02	1.10e-04
Transferrin endocytosis and recycling	26	6.00e-06	3.41e-05	0.701	0.481	0.510	2.15e-05	6.73e-06
Cargo concentration in the ER	30	5.35e-07	3.74e-06	0.699	0.425	0.555	5.63e-05	1.44e-07
Budding and maturation of HIV virion	26	7.33e-06	4.06e-05	0.696	0.480	0.503	2.23e-05	8.90e-06
Endosomal Sorting Complex Required For Transport (ESCRT)	29	2.53e-06	1.56e-05	0.688	0.489	0.484	5.07e-06	6.42e-06
Cross-presentation of soluble exogenous antigens (endosomes)	47	1.46e-10	2.23e-09	0.688	0.562	0.397	2.57e-11	2.46e-06
The NLRP3 inflammasome	15	7.59e-04	2.74e-03	0.687	0.560	0.398	1.75e-04	7.62e-03
Regulation of ornithine decarboxylase (ODC)	49	6.29e-11	1.09e-09	0.683	0.562	0.387	9.77e-12	2.70e-06
Formation of ATP by chemiosmotic coupling	18	3.96e-04	1.52e-03	0.680	0.466	0.495	6.13e-04	2.76e-04
EPHB-mediated forward signaling	32	1.00e-06	6.70e-06	0.678	0.493	0.465	1.40e-06	5.27e-06
Diseases associated with the TLR signaling cascade	23	6.14e-05	2.85e-04	0.670	0.484	0.464	5.95e-05	1.18e-04
Diseases of Immune System	23	6.14e-05	2.85e-04	0.670	0.484	0.464	5.95e-05	1.18e-04
MET activates RAP1 and RAC1	10	6.88e-03	1.94e-02	0.668	0.338	0.576	6.44e-02	1.60e-03
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD	53	3.67e-11	6.67e-10	0.668	0.545	0.386	6.52e-12	1.17e-06
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	2.60e-10	3.62e-09	0.663	0.552	0.367	3.56e-11	1.11e-05
Platelet sensitization by LDL	16	3.03e-04	1.19e-03	0.662	0.319	0.580	2.69e-02	5.85e-05
IRAK1 recruits IKK complex	10	8.50e-03	2.34e-02	0.659	0.340	0.564	6.25e-02	2.02e-03
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	8.50e-03	2.34e-02	0.659	0.340	0.564	6.25e-02	2.02e-03
Pentose phosphate pathway	13	5.13e-03	1.50e-02	0.655	0.438	0.487	6.22e-03	2.38e-03
Regulation of Apoptosis	51	9.12e-11	1.50e-09	0.653	0.549	0.353	1.13e-11	1.26e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.33e-10	2.07e-09	0.641	0.533	0.356	1.85e-11	7.13e-06

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.low.CRP	s.high.CRP	p.low.CRP	p.high.CRP
IRAK4 deficiency (TLR2/4)	10	1.45e-06	9.18e-06	1.19000	0.813000	0.875000	8.51e-06	1.65e-06
MyD88 deficiency (TLR2/4)	10	1.45e-06	9.18e-06	1.19000	0.813000	0.875000	8.51e-06	1.65e-06
Regulation of TLR by endogenous ligand	11	4.26e-06	2.48e-05	1.09000	0.798000	0.746000	4.59e-06	1.81e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	2.22e-06	1.37e-05	1.07000	0.713000	0.798000	1.90e-05	1.69e-06
alpha-linolenic acid (ALA) metabolism	12	2.22e-06	1.37e-05	1.07000	0.713000	0.798000	1.90e-05	1.69e-06
Translocation of ZAP-70 to Immunological synapse	24	2.61e-11	4.87e-10	0.98700	-0.550000	-0.819000	3.10e-06	3.60e-12
Erythrocytes take up carbon dioxide and release oxygen	11	1.14e-04	4.96e-04	0.93800	0.670000	0.656000	1.19e-04	1.64e-04
O2/CO2 exchange in erythrocytes	11	1.14e-04	4.96e-04	0.93800	0.670000	0.656000	1.19e-04	1.64e-04
Hyaluronan uptake and degradation	12	6.18e-05	2.86e-04	0.90000	0.537000	0.722000	1.29e-03	1.48e-05
Uptake and function of anthrax toxins	10	5.79e-04	2.15e-03	0.86500	0.518000	0.693000	4.59e-03	1.47e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.17e-04	5.01e-04	0.84200	0.403000	0.739000	2.06e-02	2.17e-05
Advanced glycosylation endproduct receptor signaling	12	2.06e-04	8.37e-04	0.84100	0.501000	0.676000	2.65e-03	5.01e-05
p130Cas linkage to MAPK signaling for integrins	11	8.77e-04	3.11e-03	0.82400	0.560000	0.605000	1.31e-03	5.14e-04
Detoxification of Reactive Oxygen Species	31	4.79e-09	4.60e-08	0.80700	0.605000	0.533000	5.35e-09	2.73e-07
ROS and RNS production in phagocytes	31	4.57e-09	4.45e-08	0.80600	0.610000	0.528000	4.14e-09	3.65e-07
Unwinding of DNA	12	4.92e-04	1.85e-03	0.80400	-0.492000	-0.635000	3.17e-03	1.38e-04
Insulin receptor recycling	21	3.68e-06	2.16e-05	0.79700	0.568000	0.559000	6.62e-06	9.21e-06
PD-1 signaling	28	2.29e-09	2.38e-08	0.78100	-0.372000	-0.687000	6.63e-04	3.12e-10
Neutrophil degranulation	456	5.75e-107	7.84e-104	0.76000	0.536000	0.539000	3.01e-86	2.42e-87
Phosphorylation of CD3 and TCR zeta chains	27	2.34e-07	1.73e-06	0.75800	-0.463000	-0.600000	3.13e-05	6.63e-08
Dissolution of Fibrin Clot	12	1.32e-03	4.50e-03	0.75600	0.479000	0.585000	4.08e-03	4.47e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	1.70e-03	5.57e-03	0.75200	0.540000	0.524000	1.20e-03	1.67e-03
Golgi Cisternae Pericentriolar Stack Reorganization	14	6.29e-04	2.32e-03	0.74900	0.519000	0.540000	7.78e-04	4.69e-04
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	4.88e-03	1.44e-02	0.74300	0.471000	0.574000	9.91e-03	1.67e-03
HuR (ELAVL1) binds and stabilizes mRNA	10	5.50e-03	1.60e-02	0.73000	0.573000	0.452000	1.70e-03	1.32e-02
Signaling by Leptin	10	6.91e-03	1.94e-02	0.72800	0.523000	0.507000	4.21e-03	5.54e-03
COPI-independent Golgi-to-ER retrograde traffic	33	1.39e-08	1.23e-07	0.72600	0.406000	0.602000	5.34e-05	2.14e-09
RHO GTPases Activate WASPs and WAVEs	35	1.28e-08	1.14e-07	0.72000	0.425000	0.580000	1.32e-05	2.78e-09
RHO GTPases Activate NADPH Oxidases	21	4.40e-05	2.13e-04	0.70600	0.453000	0.541000	3.24e-04	1.78e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	5.42e-04	2.04e-03	0.70200	0.331000	0.619000	3.86e-02	1.10e-04
Transferrin endocytosis and recycling	26	6.00e-06	3.41e-05	0.70100	0.481000	0.510000	2.15e-05	6.73e-06
Cargo concentration in the ER	30	5.35e-07	3.74e-06	0.69900	0.425000	0.555000	5.63e-05	1.44e-07
Budding and maturation of HIV virion	26	7.33e-06	4.06e-05	0.69600	0.480000	0.503000	2.23e-05	8.90e-06
Endosomal Sorting Complex Required For Transport (ESCRT)	29	2.53e-06	1.56e-05	0.68800	0.489000	0.484000	5.07e-06	6.42e-06
Cross-presentation of soluble exogenous antigens (endosomes)	47	1.46e-10	2.23e-09	0.68800	0.562000	0.397000	2.57e-11	2.46e-06
The NLRP3 inflammasome	15	7.59e-04	2.74e-03	0.68700	0.560000	0.398000	1.75e-04	7.62e-03
Regulation of ornithine decarboxylase (ODC)	49	6.29e-11	1.09e-09	0.68300	0.562000	0.387000	9.77e-12	2.70e-06
Formation of ATP by chemiosmotic coupling	18	3.96e-04	1.52e-03	0.68000	0.466000	0.495000	6.13e-04	2.76e-04
EPHB-mediated forward signaling	32	1.00e-06	6.70e-06	0.67800	0.493000	0.465000	1.40e-06	5.27e-06
Diseases associated with the TLR signaling cascade	23	6.14e-05	2.85e-04	0.67000	0.484000	0.464000	5.95e-05	1.18e-04
Diseases of Immune System	23	6.14e-05	2.85e-04	0.67000	0.484000	0.464000	5.95e-05	1.18e-04
MET activates RAP1 and RAC1	10	6.88e-03	1.94e-02	0.66800	0.338000	0.576000	6.44e-02	1.60e-03
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD	53	3.67e-11	6.67e-10	0.66800	0.545000	0.386000	6.52e-12	1.17e-06
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	2.60e-10	3.62e-09	0.66300	0.552000	0.367000	3.56e-11	1.11e-05
Platelet sensitization by LDL	16	3.03e-04	1.19e-03	0.66200	0.319000	0.580000	2.69e-02	5.85e-05
IRAK1 recruits IKK complex	10	8.50e-03	2.34e-02	0.65900	0.340000	0.564000	6.25e-02	2.02e-03
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	8.50e-03	2.34e-02	0.65900	0.340000	0.564000	6.25e-02	2.02e-03
Pentose phosphate pathway	13	5.13e-03	1.50e-02	0.65500	0.438000	0.487000	6.22e-03	2.38e-03
Regulation of Apoptosis	51	9.12e-11	1.50e-09	0.65300	0.549000	0.353000	1.13e-11	1.26e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.33e-10	2.07e-09	0.64100	0.533000	0.356000	1.85e-11	7.13e-06
Hh mutants abrogate ligand secretion	54	1.81e-10	2.65e-09	0.63700	0.523000	0.363000	2.95e-11	3.84e-06
Inflammasomes	20	1.23e-04	5.29e-04	0.63500	0.548000	0.322000	2.21e-05	1.27e-02
Butyrophilin (BTN) family interactions	10	1.31e-02	3.41e-02	0.63500	-0.339000	-0.537000	6.38e-02	3.27e-03
Generation of second messenger molecules	38	4.49e-08	3.69e-07	0.63400	-0.324000	-0.545000	5.52e-04	5.99e-09
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	6.52e-10	7.87e-09	0.63100	0.531000	0.341000	8.37e-11	3.01e-05
p53-Independent DNA Damage Response	50	6.52e-10	7.87e-09	0.63100	0.531000	0.341000	8.37e-11	3.01e-05
p53-Independent G1/S DNA damage checkpoint	50	6.52e-10	7.87e-09	0.63100	0.531000	0.341000	8.37e-11	3.01e-05
Smooth Muscle Contraction	30	1.08e-05	5.75e-05	0.63100	0.406000	0.483000	1.18e-04	4.74e-06
Vif-mediated degradation of APOBEC3G	52	4.96e-10	6.32e-09	0.63000	0.522000	0.353000	7.29e-11	1.05e-05
Defective CFTR causes cystic fibrosis	58	9.45e-11	1.53e-09	0.63000	0.509000	0.372000	2.04e-11	9.73e-07
ATF6 (ATF6-alpha) activates chaperone genes	10	1.12e-02	2.98e-02	0.62600	0.546000	0.306000	2.76e-03	9.36e-02
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	4.62e-10	6.00e-09	0.62500	0.524000	0.339000	5.98e-11	2.29e-05
Interleukin-1 signaling	97	4.68e-16	2.13e-14	0.61900	0.467000	0.406000	1.77e-15	4.61e-12
Vpu mediated degradation of CD4	50	1.44e-09	1.60e-08	0.61800	0.521000	0.334000	1.87e-10	4.41e-05
RNA Polymerase I Promoter Opening	19	1.59e-04	6.63e-04	0.61800	0.280000	0.551000	3.43e-02	3.22e-05
Degradation of GLI2 by the proteasome	56	2.30e-10	3.26e-09	0.61800	0.512000	0.346000	3.32e-11	7.62e-06
GLI3 is processed to GLI3R by the proteasome	56	2.30e-10	3.26e-09	0.61800	0.512000	0.346000	3.32e-11	7.62e-06
MAP2K and MAPK activation	34	2.70e-06	1.63e-05	0.61600	0.370000	0.493000	1.86e-04	6.56e-07
Negative regulation of NOTCH4 signaling	54	5.24e-10	6.61e-09	0.61300	0.513000	0.335000	6.95e-11	2.03e-05
Hedgehog ligand biogenesis	58	2.71e-10	3.71e-09	0.61300	0.498000	0.356000	5.09e-11	2.70e-06
Negative regulation of MET activity	18	1.23e-03	4.19e-03	0.61200	0.368000	0.489000	6.88e-03	3.24e-04
Translation of Replicase and Assembly of the Replication Transcription Complex	12	1.49e-02	3.81e-02	0.60900	0.450000	0.410000	6.95e-03	1.38e-02
NIK–>noncanonical NF-kB signaling	57	1.30e-10	2.04e-09	0.60800	0.516000	0.321000	1.54e-11	2.68e-05
Antimicrobial peptides	33	1.16e-06	7.65e-06	0.60600	0.525000	0.302000	1.73e-07	2.70e-03
Ubiquitin-dependent degradation of Cyclin D	50	4.17e-09	4.12e-08	0.60400	0.507000	0.328000	5.64e-10	5.93e-05
Folding of actin by CCT/TriC	10	4.78e-03	1.42e-02	0.60300	0.570000	0.197000	1.81e-03	2.80e-01
InlB-mediated entry of Listeria monocytogenes into host cell	12	1.65e-02	4.16e-02	0.60200	0.409000	0.442000	1.42e-02	7.99e-03
Metabolism of polyamines	57	1.84e-10	2.67e-09	0.60000	0.512000	0.312000	2.16e-11	4.49e-05
Cytochrome c-mediated apoptotic response	13	1.06e-02	2.86e-02	0.60000	0.467000	0.376000	3.52e-03	1.89e-02
Formation of apoptosome	11	2.41e-02	5.48e-02	0.60000	0.438000	0.410000	1.19e-02	1.86e-02
Regulation of the apoptosome activity	11	2.41e-02	5.48e-02	0.60000	0.438000	0.410000	1.19e-02	1.86e-02
Degradation of GLI1 by the proteasome	57	6.15e-10	7.63e-09	0.59900	0.496000	0.336000	9.16e-11	1.11e-05
RHO GTPases activate IQGAPs	11	1.03e-02	2.77e-02	0.59800	0.285000	0.526000	1.02e-01	2.54e-03
mTORC1-mediated signalling	24	3.24e-04	1.27e-03	0.59700	0.430000	0.414000	2.67e-04	4.40e-04
Hyaluronan metabolism	15	2.73e-03	8.58e-03	0.59700	0.306000	0.512000	4.02e-02	5.91e-04
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models	20	8.61e-04	3.06e-03	0.59400	0.353000	0.478000	6.33e-03	2.15e-04
Neurodegenerative Diseases	20	8.61e-04	3.06e-03	0.59400	0.353000	0.478000	6.33e-03	2.15e-04
GRB2 events in EGFR signaling	10	2.82e-02	6.20e-02	0.59400	0.346000	0.483000	5.84e-02	8.22e-03
SHC1 events in EGFR signaling	11	1.95e-02	4.62e-02	0.59300	0.343000	0.484000	4.85e-02	5.45e-03
Dectin-1 mediated noncanonical NF-kB signaling	58	2.75e-10	3.71e-09	0.59300	0.503000	0.314000	3.31e-11	3.56e-05
Retrograde neurotrophin signalling	12	5.63e-03	1.63e-02	0.59200	0.260000	0.532000	1.19e-01	1.43e-03
Degradation of DVL	54	5.38e-09	5.09e-08	0.58900	0.481000	0.340000	9.71e-10	1.53e-05
Signaling by high-kinase activity BRAF mutants	31	2.36e-05	1.18e-04	0.58700	0.349000	0.471000	7.60e-04	5.52e-06
The role of GTSE1 in G2/M progression after G2 checkpoint	58	3.09e-10	4.13e-09	0.58500	0.502000	0.301000	3.64e-11	7.50e-05
activated TAK1 mediates p38 MAPK activation	19	1.40e-03	4.72e-03	0.58400	0.338000	0.476000	1.07e-02	3.31e-04
Autodegradation of the E3 ubiquitin ligase COP1	49	1.44e-08	1.27e-07	0.58300	0.496000	0.307000	1.89e-09	2.00e-04
Antigen processing-Cross presentation	97	1.34e-14	5.09e-13	0.58100	0.457000	0.360000	7.43e-15	9.10e-10
Regulation of IFNG signaling	14	1.23e-02	3.22e-02	0.57800	0.401000	0.417000	9.41e-03	6.92e-03
SCF-beta-TrCP mediated degradation of Emi1	53	2.78e-09	2.85e-08	0.57700	0.498000	0.292000	3.46e-10	2.35e-04
Trafficking of GluR2-containing AMPA receptors	12	4.26e-04	1.62e-03	0.57700	0.081700	0.571000	6.24e-01	6.10e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	1.37e-09	1.53e-08	0.57600	0.444000	0.367000	8.09e-10	3.83e-07
Activation of the AP-1 family of transcription factors	10	4.28e-02	8.67e-02	0.57500	0.435000	0.377000	1.73e-02	3.92e-02
Platelet degranulation	104	5.72e-15	2.36e-13	0.57200	0.363000	0.442000	1.51e-10	6.13e-15
ATF6 (ATF6-alpha) activates chaperones	12	2.09e-02	4.88e-02	0.56900	0.456000	0.341000	6.24e-03	4.10e-02
Response to elevated platelet cytosolic Ca2+	108	1.77e-15	7.55e-14	0.56900	0.353000	0.446000	2.17e-10	1.17e-15
Apoptotic factor-mediated response	18	2.13e-03	6.85e-03	0.56900	0.476000	0.310000	4.66e-04	2.27e-02
Late endosomal microautophagy	29	1.52e-04	6.38e-04	0.56800	0.413000	0.390000	1.18e-04	2.81e-04
Response of EIF2AK1 (HRI) to heme deficiency	14	3.56e-03	1.09e-02	0.56700	0.512000	0.243000	9.04e-04	1.16e-01
Signal transduction by L1	20	3.61e-04	1.40e-03	0.56500	0.246000	0.509000	5.72e-02	8.12e-05
Cellular response to hypoxia	71	5.74e-10	7.17e-09	0.56500	0.412000	0.386000	1.84e-09	1.87e-08
Signal regulatory protein family interactions	12	2.83e-02	6.21e-02	0.56200	0.390000	0.405000	1.93e-02	1.51e-02
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	1.35e-04	5.70e-04	0.56100	0.416000	0.375000	7.86e-05	3.74e-04
ER-Phagosome pathway	82	6.25e-12	1.44e-10	0.55900	0.453000	0.328000	1.28e-12	2.87e-07
Lysosome Vesicle Biogenesis	32	5.17e-05	2.45e-04	0.55900	0.338000	0.445000	9.37e-04	1.33e-05
Interleukin-6 signaling	10	5.19e-02	1.01e-01	0.55800	0.420000	0.368000	2.16e-02	4.41e-02
Mitochondrial iron-sulfur cluster biogenesis	13	3.51e-03	1.07e-02	0.55600	0.520000	0.197000	1.18e-03	2.19e-01
COPI-mediated anterograde transport	78	5.18e-11	9.29e-10	0.55500	0.338000	0.441000	2.53e-07	1.62e-11
Metabolism of Angiotensinogen to Angiotensins	11	9.60e-03	2.60e-02	0.55500	0.515000	0.205000	3.09e-03	2.38e-01
RHO GTPases Activate ROCKs	18	2.84e-03	8.87e-03	0.55200	0.297000	0.466000	2.93e-02	6.26e-04
Cristae formation	31	1.07e-04	4.74e-04	0.55000	0.431000	0.342000	3.24e-05	9.91e-04
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	1.44e-02	3.69e-02	0.54900	0.397000	0.379000	7.83e-03	1.10e-02
Autodegradation of Cdh1 by Cdh1:APC/C	64	8.68e-10	1.00e-08	0.54700	0.467000	0.286000	1.06e-10	7.53e-05
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	92	3.97e-12	9.49e-11	0.54700	0.353000	0.417000	4.95e-09	4.38e-12
Toll Like Receptor 2 (TLR2) Cascade	92	3.97e-12	9.49e-11	0.54700	0.353000	0.417000	4.95e-09	4.38e-12
Toll Like Receptor TLR1:TLR2 Cascade	92	3.97e-12	9.49e-11	0.54700	0.353000	0.417000	4.95e-09	4.38e-12
Toll Like Receptor TLR6:TLR2 Cascade	92	3.97e-12	9.49e-11	0.54700	0.353000	0.417000	4.95e-09	4.38e-12
APC/C:Cdc20 mediated degradation of Securin	66	9.94e-10	1.13e-08	0.54200	0.458000	0.290000	1.26e-10	4.54e-05
Degradation of AXIN	53	7.74e-08	6.10e-07	0.54100	0.453000	0.294000	1.12e-08	2.09e-04
COPII-mediated vesicle transport	65	2.83e-09	2.88e-08	0.54000	0.302000	0.448000	2.50e-05	4.23e-10
WNT5A-dependent internalization of FZD4	13	1.81e-03	5.91e-03	0.54000	0.133000	0.523000	4.05e-01	1.09e-03
Stabilization of p53	54	5.25e-08	4.28e-07	0.53900	0.455000	0.290000	7.34e-09	2.26e-04
CD22 mediated BCR regulation	58	2.23e-20	1.90e-18	0.53900	0.069000	-0.534000	3.63e-01	1.87e-12
Response of Mtb to phagocytosis	22	2.58e-03	8.15e-03	0.53700	0.378000	0.382000	2.12e-03	1.94e-03
RHO GTPases activate KTN1	11	5.06e-02	9.85e-02	0.53700	0.368000	0.391000	3.48e-02	2.46e-02
DNA strand elongation	32	3.43e-06	2.03e-05	0.53700	-0.201000	-0.498000	4.96e-02	1.09e-06
Pyrimidine salvage	10	6.60e-02	1.22e-01	0.53600	0.397000	0.360000	2.96e-02	4.85e-02
Spry regulation of FGF signaling	16	8.44e-03	2.34e-02	0.53500	0.297000	0.444000	3.96e-02	2.08e-03
ABC transporter disorders	69	3.39e-09	3.37e-08	0.53400	0.427000	0.321000	8.59e-10	4.05e-06
Josephin domain DUBs	10	6.87e-02	1.27e-01	0.53400	0.369000	0.386000	4.33e-02	3.47e-02
Infection with Mycobacterium tuberculosis	26	9.89e-04	3.42e-03	0.53200	0.385000	0.367000	6.72e-04	1.19e-03
VLDLR internalisation and degradation	11	9.92e-03	2.68e-02	0.53200	0.171000	0.503000	3.26e-01	3.83e-03
Cell recruitment (pro-inflammatory response)	22	9.65e-04	3.35e-03	0.53100	0.459000	0.267000	1.95e-04	3.02e-02
Purinergic signaling in leishmaniasis infection	22	9.65e-04	3.35e-03	0.53100	0.459000	0.267000	1.95e-04	3.02e-02
Signaling by RAF1 mutants	34	1.04e-04	4.67e-04	0.53000	0.339000	0.407000	6.23e-04	3.97e-05
Regulation of PTEN stability and activity	66	2.68e-08	2.24e-07	0.52800	0.395000	0.351000	2.84e-08	8.12e-07
Regulation of mRNA stability by proteins that bind AU-rich elements	87	8.27e-12	1.85e-10	0.52800	0.442000	0.289000	1.03e-12	3.15e-06
CDT1 association with the CDC6:ORC:origin complex	57	1.64e-08	1.43e-07	0.52700	0.458000	0.261000	2.18e-09	6.58e-04
MET activates RAS signaling	10	7.02e-02	1.29e-01	0.52300	0.407000	0.328000	2.57e-02	7.23e-02
Regulation of RUNX3 expression and activity	55	2.11e-07	1.59e-06	0.52300	0.429000	0.299000	3.75e-08	1.26e-04
ER to Golgi Anterograde Transport	129	4.01e-16	1.88e-14	0.52200	0.304000	0.424000	2.52e-09	8.03e-17
Activation of NF-kappaB in B cells	65	1.90e-08	1.62e-07	0.52100	0.423000	0.304000	3.71e-09	2.28e-05
Assembly Of The HIV Virion	15	2.27e-02	5.23e-02	0.51900	0.365000	0.368000	1.43e-02	1.36e-02
Iron uptake and transport	52	1.86e-06	1.17e-05	0.51900	0.384000	0.348000	1.62e-06	1.41e-05
Gap junction trafficking	13	1.78e-02	4.42e-02	0.51800	0.250000	0.454000	1.18e-01	4.61e-03
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.71e-09	1.86e-08	0.51700	0.432000	0.285000	2.38e-10	2.83e-05
Classical antibody-mediated complement activation	68	3.04e-23	4.60e-21	0.51700	0.098600	-0.507000	1.60e-01	4.48e-13
Energy dependent regulation of mTOR by LKB1-AMPK	27	1.04e-03	3.58e-03	0.51300	0.326000	0.397000	3.41e-03	3.54e-04
Scavenging of heme from plasma	70	3.83e-27	7.46e-25	0.51300	0.192000	-0.476000	5.38e-03	5.82e-12
Alpha-protein kinase 1 signaling pathway	11	5.94e-02	1.14e-01	0.51300	0.402000	0.318000	2.08e-02	6.81e-02
trans-Golgi Network Vesicle Budding	69	4.62e-09	4.46e-08	0.50800	0.269000	0.431000	1.13e-04	5.92e-10
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	4.03e-02	8.29e-02	0.50800	0.251000	0.441000	1.49e-01	1.13e-02
Erythropoietin activates RAS	13	4.31e-02	8.72e-02	0.50700	0.346000	0.371000	3.10e-02	2.07e-02
RUNX1 regulates transcription of genes involved in differentiation of HSCs	82	2.77e-09	2.85e-08	0.50700	0.361000	0.356000	1.63e-08	2.51e-08
Integrin signaling	22	1.65e-03	5.43e-03	0.50600	0.249000	0.440000	4.34e-02	3.48e-04
GAB1 signalosome	14	2.64e-03	8.34e-03	0.50500	0.126000	0.489000	4.15e-01	1.52e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	8.51e-10	9.91e-09	0.50400	0.442000	0.240000	1.13e-10	4.58e-04
Effects of PIP2 hydrolysis	24	4.50e-04	1.71e-03	0.50300	-0.457000	-0.212000	1.08e-04	7.23e-02
Respiratory electron transport	101	1.86e-11	3.76e-10	0.50300	0.391000	0.317000	1.08e-11	3.80e-08
SCF(Skp2)-mediated degradation of p27/p21	60	2.96e-08	2.46e-07	0.50300	0.439000	0.246000	4.06e-09	9.92e-04
Collagen degradation	28	3.93e-04	1.51e-03	0.50300	0.256000	0.432000	1.88e-02	7.48e-05
Prolonged ERK activation events	13	2.21e-02	5.10e-02	0.50300	0.241000	0.441000	1.33e-01	5.85e-03
Paradoxical activation of RAF signaling by kinase inactive BRAF	38	1.15e-04	4.96e-04	0.50300	0.337000	0.373000	3.30e-04	6.79e-05
Signaling by RAS mutants	38	1.15e-04	4.96e-04	0.50300	0.337000	0.373000	3.30e-04	6.79e-05
Signaling by moderate kinase activity BRAF mutants	38	1.15e-04	4.96e-04	0.50300	0.337000	0.373000	3.30e-04	6.79e-05
Signaling downstream of RAS mutants	38	1.15e-04	4.96e-04	0.50300	0.337000	0.373000	3.30e-04	6.79e-05
Platelet Adhesion to exposed collagen	13	4.11e-02	8.42e-02	0.50200	0.313000	0.392000	5.04e-02	1.43e-02
Golgi Associated Vesicle Biogenesis	55	4.29e-07	3.07e-06	0.50100	0.272000	0.421000	4.82e-04	6.46e-08
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	8.04e-05	3.65e-04	0.50100	0.416000	0.279000	1.53e-05	3.75e-03
HDR through MMEJ (alt-NHEJ)	10	8.62e-02	1.49e-01	0.50000	-0.307000	-0.394000	9.22e-02	3.08e-02
Biotin transport and metabolism	11	6.81e-02	1.26e-01	0.50000	-0.393000	-0.308000	2.39e-02	7.70e-02
Creation of C4 and C2 activators	70	8.44e-23	9.58e-21	0.49700	0.112000	-0.484000	1.06e-01	2.41e-12
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	87	1.61e-09	1.77e-08	0.49600	0.327000	0.373000	1.35e-07	1.88e-09
Signaling by NOTCH4	78	6.11e-09	5.67e-08	0.49500	0.395000	0.299000	1.63e-09	4.90e-06
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	1.07e-09	1.21e-08	0.49500	0.437000	0.234000	1.48e-10	5.99e-04
MTOR signalling	39	1.10e-04	4.83e-04	0.49500	0.320000	0.377000	5.37e-04	4.62e-05
Membrane binding and targetting of GAG proteins	13	5.03e-02	9.80e-02	0.49500	0.359000	0.340000	2.49e-02	3.39e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	5.03e-02	9.80e-02	0.49500	0.359000	0.340000	2.49e-02	3.39e-02
CDK-mediated phosphorylation and removal of Cdc6	71	5.59e-09	5.26e-08	0.49400	0.423000	0.256000	7.07e-10	1.93e-04
FCGR activation	75	8.30e-23	9.58e-21	0.49400	0.079900	-0.488000	2.31e-01	2.73e-13
Toll Like Receptor 4 (TLR4) Cascade	121	7.69e-13	2.05e-11	0.49400	0.326000	0.371000	5.97e-10	1.80e-12
Regulated proteolysis of p75NTR	11	7.63e-02	1.36e-01	0.49400	0.317000	0.378000	6.89e-02	2.97e-02
LDL clearance	17	1.87e-02	4.51e-02	0.49300	0.316000	0.379000	2.40e-02	6.82e-03
MASTL Facilitates Mitotic Progression	10	2.74e-02	6.04e-02	0.49300	0.467000	0.160000	1.06e-02	3.81e-01
Interleukin-1 family signaling	124	5.86e-13	1.60e-11	0.49200	0.359000	0.336000	4.74e-12	9.59e-11
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	124	3.60e-13	1.02e-11	0.49100	0.378000	0.314000	3.72e-13	1.50e-09
Suppression of phagosomal maturation	12	6.39e-02	1.20e-01	0.49100	0.321000	0.371000	5.40e-02	2.62e-02
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	8.14e-10	9.56e-09	0.49000	0.431000	0.234000	1.08e-10	4.61e-04
APC/C:Cdc20 mediated degradation of mitotic proteins	74	9.19e-10	1.05e-08	0.49000	0.432000	0.231000	1.27e-10	5.93e-04
IKK complex recruitment mediated by RIP1	23	5.00e-03	1.47e-02	0.49000	0.376000	0.314000	1.81e-03	9.07e-03
Toll Like Receptor 7/8 (TLR7/8) Cascade	89	1.82e-09	1.96e-08	0.48900	0.324000	0.366000	1.30e-07	2.29e-09
Signal amplification	28	1.87e-03	6.05e-03	0.48800	0.334000	0.356000	2.22e-03	1.10e-03
Glycogen synthesis	13	5.44e-02	1.05e-01	0.48800	0.340000	0.351000	3.39e-02	2.85e-02
Growth hormone receptor signaling	20	1.10e-02	2.94e-02	0.48700	0.366000	0.322000	4.61e-03	1.27e-02
DARPP-32 events	22	3.41e-03	1.04e-02	0.48600	0.253000	0.415000	3.97e-02	7.50e-04
CLEC7A (Dectin-1) signaling	96	2.50e-10	3.51e-09	0.48500	0.383000	0.298000	8.76e-11	4.45e-07
EPH-Ephrin signaling	78	3.12e-08	2.58e-07	0.48500	0.327000	0.359000	6.11e-07	4.35e-08
Prefoldin mediated transfer of substrate to CCT/TriC	26	1.82e-03	5.91e-03	0.48300	0.401000	0.270000	4.05e-04	1.71e-02
Platelet Aggregation (Plug Formation)	28	3.46e-04	1.35e-03	0.48300	0.215000	0.432000	4.85e-02	7.44e-05
RHO GTPases activate PKNs	47	7.63e-07	5.17e-06	0.48300	0.198000	0.440000	1.87e-02	1.78e-07
CD28 dependent PI3K/Akt signaling	22	5.42e-03	1.58e-02	0.48100	-0.395000	-0.275000	1.34e-03	2.55e-02
Packaging Of Telomere Ends	20	8.89e-04	3.15e-03	0.48100	0.148000	0.458000	2.53e-01	3.92e-04
Scavenging by Class A Receptors	11	3.11e-02	6.71e-02	0.47900	0.177000	0.445000	3.09e-01	1.06e-02
Toll-like Receptor Cascades	143	3.96e-14	1.32e-12	0.47900	0.322000	0.354000	2.73e-11	2.48e-13
MyD88 dependent cascade initiated on endosome	88	5.14e-09	4.90e-08	0.47900	0.316000	0.359000	2.96e-07	5.59e-09
SHC1 events in ERBB4 signaling	10	8.75e-02	1.51e-01	0.47700	0.403000	0.257000	2.75e-02	1.60e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR)	36	2.43e-04	9.64e-04	0.47700	0.276000	0.389000	4.18e-03	5.31e-05
Activation of the pre-replicative complex	32	4.51e-05	2.17e-04	0.47600	-0.174000	-0.443000	8.85e-02	1.46e-05
MyD88 cascade initiated on plasma membrane	82	1.81e-08	1.55e-07	0.47500	0.301000	0.367000	2.40e-06	8.68e-09
Toll Like Receptor 10 (TLR10) Cascade	82	1.81e-08	1.55e-07	0.47500	0.301000	0.367000	2.40e-06	8.68e-09
Toll Like Receptor 5 (TLR5) Cascade	82	1.81e-08	1.55e-07	0.47500	0.301000	0.367000	2.40e-06	8.68e-09
Mucopolysaccharidoses	11	7.09e-02	1.30e-01	0.47500	0.256000	0.400000	1.41e-01	2.16e-02
EGFR downregulation	26	1.48e-04	6.24e-04	0.47500	0.148000	0.451000	1.90e-01	6.85e-05
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	29	1.42e-03	4.79e-03	0.47400	0.384000	0.277000	3.46e-04	9.72e-03
Amyloid fiber formation	51	1.04e-05	5.58e-05	0.47300	0.277000	0.383000	6.15e-04	2.22e-06
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	22	5.74e-05	2.71e-04	0.47200	0.058000	0.468000	6.38e-01	1.42e-04
Complex I biogenesis	55	1.04e-05	5.58e-05	0.47200	0.341000	0.325000	1.19e-05	2.98e-05
Apoptosis induced DNA fragmentation	10	7.34e-02	1.32e-01	0.47100	0.221000	0.416000	2.27e-01	2.27e-02
Initial triggering of complement	77	1.26e-22	1.32e-20	0.47100	0.109000	-0.458000	9.93e-02	3.62e-12
Innate Immune System	963	8.82e-86	6.01e-83	0.47000	0.357000	0.306000	4.15e-79	2.68e-58
Recycling pathway of L1	26	4.84e-04	1.83e-03	0.46600	0.178000	0.431000	1.17e-01	1.41e-04
SUMOylation of immune response proteins	11	8.26e-02	1.45e-01	0.46600	0.260000	0.387000	1.36e-01	2.62e-02
Toll Like Receptor 9 (TLR9) Cascade	92	5.87e-09	5.48e-08	0.46600	0.305000	0.352000	4.10e-07	5.42e-09
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	3.95e-02	8.15e-02	0.46500	0.202000	0.419000	2.26e-01	1.19e-02
Diseases of hemostasis	12	3.95e-02	8.15e-02	0.46500	0.202000	0.419000	2.26e-01	1.19e-02
Calnexin/calreticulin cycle	26	3.70e-03	1.12e-02	0.46400	0.276000	0.373000	1.49e-02	9.82e-04
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	12	4.89e-02	9.63e-02	0.46200	0.408000	0.217000	1.43e-02	1.93e-01
Common Pathway of Fibrin Clot Formation	14	3.78e-02	7.87e-02	0.46200	0.239000	0.395000	1.21e-01	1.05e-02
Signalling to ERKs	31	2.07e-03	6.66e-03	0.46100	0.322000	0.330000	1.92e-03	1.47e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	1.91e-02	4.56e-02	0.46000	0.394000	0.237000	4.90e-03	9.05e-02
Nucleotide salvage	21	1.29e-02	3.36e-02	0.45800	0.365000	0.277000	3.81e-03	2.82e-02
Post-translational protein phosphorylation	68	1.23e-06	8.01e-06	0.45700	0.292000	0.351000	3.15e-05	5.45e-07
The citric acid (TCA) cycle and respiratory electron transport	172	1.46e-15	6.41e-14	0.45600	0.351000	0.290000	1.93e-15	4.96e-11
Regulation of APC/C activators between G1/S and early anaphase	79	2.22e-09	2.35e-08	0.45500	0.408000	0.203000	3.72e-10	1.79e-03
Signaling by PDGFRA extracellular domain mutants	12	8.43e-02	1.47e-01	0.45300	0.366000	0.268000	2.83e-02	1.08e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	8.43e-02	1.47e-01	0.45300	0.366000	0.268000	2.83e-02	1.08e-01
ERK/MAPK targets	22	1.17e-02	3.09e-02	0.45300	0.277000	0.359000	2.46e-02	3.55e-03
ADP signalling through P2Y purinoceptor 1	21	1.75e-02	4.38e-02	0.45300	0.329000	0.311000	9.04e-03	1.37e-02
Citric acid cycle (TCA cycle)	22	1.46e-02	3.73e-02	0.45200	0.314000	0.326000	1.08e-02	8.14e-03
Signaling by BRAF and RAF fusions	57	1.35e-05	7.15e-05	0.45200	0.287000	0.349000	1.81e-04	5.08e-06
Receptor Mediated Mitophagy	11	1.17e-01	1.91e-01	0.45100	0.293000	0.344000	9.29e-02	4.83e-02
Gastrin-CREB signalling pathway via PKC and MAPK	14	3.89e-02	8.07e-02	0.45000	0.220000	0.393000	1.54e-01	1.09e-02
Hedgehog ‘on’ state	74	2.24e-07	1.67e-06	0.45000	0.369000	0.256000	3.94e-08	1.36e-04
FRS-mediated FGFR3 signaling	11	7.16e-02	1.30e-01	0.44900	0.398000	0.208000	2.22e-02	2.31e-01
G1/S DNA Damage Checkpoints	65	5.79e-07	4.02e-06	0.44900	0.384000	0.232000	8.35e-08	1.19e-03
Diseases associated with glycosylation precursor biosynthesis	18	2.19e-02	5.07e-02	0.44900	0.375000	0.246000	5.82e-03	7.04e-02
p53-Dependent G1 DNA Damage Response	63	1.16e-06	7.65e-06	0.44900	0.381000	0.238000	1.74e-07	1.07e-03
p53-Dependent G1/S DNA damage checkpoint	63	1.16e-06	7.65e-06	0.44900	0.381000	0.238000	1.74e-07	1.07e-03
Regulation of RUNX2 expression and activity	66	3.52e-07	2.55e-06	0.44800	0.388000	0.225000	5.02e-08	1.55e-03
RHO GTPases activate PAKs	20	5.94e-03	1.70e-02	0.44800	0.187000	0.407000	1.49e-01	1.61e-03
DNA methylation	20	2.76e-03	8.64e-03	0.44700	0.146000	0.423000	2.58e-01	1.06e-03
MAP kinase activation	63	5.52e-06	3.16e-05	0.44600	0.282000	0.346000	1.09e-04	2.03e-06
Asymmetric localization of PCP proteins	60	7.60e-06	4.16e-05	0.44400	0.356000	0.265000	1.78e-06	3.83e-04
Golgi-to-ER retrograde transport	111	7.08e-10	8.39e-09	0.44300	0.279000	0.345000	3.89e-07	3.43e-10
Gluconeogenesis	28	5.97e-03	1.71e-02	0.44200	0.315000	0.310000	3.93e-03	4.57e-03
Incretin synthesis, secretion, and inactivation	10	2.71e-02	6.00e-02	0.44100	0.435000	0.077200	1.73e-02	6.73e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	10	2.71e-02	6.00e-02	0.44100	0.435000	0.077200	1.73e-02	6.73e-01
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	4.67e-02	9.31e-02	0.44100	0.268000	0.350000	6.30e-02	1.55e-02
RAB geranylgeranylation	61	1.06e-05	5.66e-05	0.43900	0.273000	0.344000	2.25e-04	3.32e-06
Pyruvate metabolism	28	5.65e-03	1.63e-02	0.43900	0.337000	0.282000	2.05e-03	9.85e-03
G beta:gamma signalling through CDC42	17	4.03e-02	8.29e-02	0.43800	0.347000	0.268000	1.33e-02	5.55e-02
Processive synthesis on the lagging strand	15	8.16e-04	2.92e-03	0.43800	0.021300	-0.438000	8.86e-01	3.33e-03
Activation of Matrix Metalloproteinases	23	1.56e-02	3.95e-02	0.43800	0.298000	0.321000	1.34e-02	7.61e-03
Autophagy	123	2.74e-10	3.71e-09	0.43800	0.306000	0.313000	4.39e-09	2.09e-09
Phase 0 - rapid depolarisation	22	1.55e-02	3.94e-02	0.43800	-0.348000	-0.265000	4.66e-03	3.16e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	27	7.05e-03	1.97e-02	0.43700	0.280000	0.335000	1.17e-02	2.55e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	48	1.03e-04	4.65e-04	0.43700	0.258000	0.352000	1.99e-03	2.38e-05
MAPK6/MAPK4 signaling	82	1.56e-07	1.19e-06	0.43500	0.354000	0.254000	3.07e-08	7.06e-05
Activation of ATR in response to replication stress	36	9.21e-05	4.16e-04	0.43500	-0.162000	-0.403000	9.21e-02	2.81e-05
Sealing of the nuclear envelope (NE) by ESCRT-III	25	6.91e-03	1.94e-02	0.43400	0.237000	0.364000	4.04e-02	1.65e-03
Downstream signaling events of B Cell Receptor (BCR)	79	3.33e-07	2.43e-06	0.43200	0.351000	0.252000	6.58e-08	1.07e-04
APC/C-mediated degradation of cell cycle proteins	86	2.88e-09	2.88e-08	0.43200	0.388000	0.190000	5.07e-10	2.27e-03
Regulation of mitotic cell cycle	86	2.88e-09	2.88e-08	0.43200	0.388000	0.190000	5.07e-10	2.27e-03
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	6.04e-02	1.15e-01	0.43200	0.316000	0.294000	2.87e-02	4.16e-02
ADP signalling through P2Y purinoceptor 12	18	4.24e-02	8.61e-02	0.43100	0.318000	0.292000	1.96e-02	3.20e-02
PCP/CE pathway	86	3.06e-07	2.24e-06	0.43100	0.292000	0.317000	2.94e-06	3.74e-07
MyD88-independent TLR4 cascade	96	5.83e-08	4.70e-07	0.43000	0.292000	0.315000	7.40e-07	9.40e-08
TRIF(TICAM1)-mediated TLR4 signaling	96	5.83e-08	4.70e-07	0.43000	0.292000	0.315000	7.40e-07	9.40e-08
Tryptophan catabolism	12	1.18e-01	1.92e-01	0.42900	0.334000	0.269000	4.54e-02	1.06e-01
Transcriptional regulation of granulopoiesis	46	2.13e-04	8.57e-04	0.42800	0.253000	0.345000	2.96e-03	5.02e-05
Interleukin-17 signaling	68	5.99e-06	3.41e-05	0.42700	0.268000	0.333000	1.29e-04	2.09e-06
Role of LAT2/NTAL/LAB on calcium mobilization	73	1.98e-19	1.30e-17	0.42600	0.150000	-0.399000	2.71e-02	3.62e-09
Constitutive Signaling by EGFRvIII	14	8.58e-02	1.49e-01	0.42500	0.332000	0.265000	3.15e-02	8.63e-02
Signaling by EGFRvIII in Cancer	14	8.58e-02	1.49e-01	0.42500	0.332000	0.265000	3.15e-02	8.63e-02
Transport to the Golgi and subsequent modification	155	7.81e-14	2.53e-12	0.42400	0.223000	0.361000	1.74e-06	8.01e-15
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	51	8.74e-05	3.96e-04	0.42400	0.347000	0.244000	1.81e-05	2.59e-03
RAF activation	32	4.58e-03	1.36e-02	0.42300	0.291000	0.307000	4.36e-03	2.63e-03
Glycogen breakdown (glycogenolysis)	13	7.11e-02	1.30e-01	0.42300	0.208000	0.368000	1.94e-01	2.16e-02
ER Quality Control Compartment (ERQC)	21	2.50e-02	5.67e-02	0.42200	0.257000	0.335000	4.18e-02	7.87e-03
Pre-NOTCH Processing in Golgi	18	2.11e-04	8.52e-04	0.42000	-0.050600	0.417000	7.10e-01	2.20e-03
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	2.58e-02	5.75e-02	0.41900	0.279000	0.313000	2.34e-02	1.12e-02
Signaling by MET	60	1.78e-05	9.24e-05	0.41800	0.233000	0.348000	1.84e-03	3.18e-06
Amino acids regulate mTORC1	50	2.33e-04	9.30e-04	0.41600	0.263000	0.323000	1.31e-03	7.82e-05
TNFR1-induced proapoptotic signaling	12	5.05e-02	9.83e-02	0.41600	-0.142000	-0.391000	3.94e-01	1.90e-02
C-type lectin receptors (CLRs)	128	4.07e-10	5.34e-09	0.41600	0.328000	0.255000	1.41e-10	5.98e-07
AKT phosphorylates targets in the cytosol	14	2.84e-02	6.22e-02	0.41500	0.135000	0.393000	3.81e-01	1.09e-02
ERKs are inactivated	13	7.24e-02	1.31e-01	0.41500	0.197000	0.366000	2.20e-01	2.23e-02
Lagging Strand Synthesis	20	5.76e-04	2.14e-03	0.41500	-0.025400	-0.415000	8.44e-01	1.33e-03
Glycogen storage diseases	13	1.21e-01	1.95e-01	0.41500	0.307000	0.279000	5.50e-02	8.18e-02
Regulation of TP53 Activity through Acetylation	29	6.70e-04	2.46e-03	0.41500	-0.392000	-0.137000	2.61e-04	2.02e-01
RAB GEFs exchange GTP for GDP on RABs	87	1.19e-08	1.08e-07	0.41400	0.184000	0.371000	3.08e-03	2.09e-09
Interleukin-12 signaling	44	2.54e-04	1.01e-03	0.41300	0.354000	0.213000	4.72e-05	1.47e-02
Degradation of beta-catenin by the destruction complex	83	7.78e-07	5.25e-06	0.41200	0.332000	0.245000	1.76e-07	1.12e-04
Thromboxane signalling through TP receptor	20	3.83e-02	7.96e-02	0.41200	0.317000	0.263000	1.42e-02	4.17e-02
Triglyceride catabolism	16	6.49e-02	1.21e-01	0.41100	0.238000	0.334000	9.86e-02	2.06e-02
PINK1-PRKN Mediated Mitophagy	21	6.01e-03	1.71e-02	0.41000	0.386000	0.138000	2.19e-03	2.73e-01
Inhibition of DNA recombination at telomere	35	9.07e-04	3.20e-03	0.41000	0.189000	0.364000	5.29e-02	1.95e-04
Removal of the Flap Intermediate	14	1.54e-03	5.14e-03	0.41000	0.062400	-0.405000	6.86e-01	8.67e-03
Regulation of RAS by GAPs	66	2.31e-05	1.16e-04	0.40900	0.318000	0.258000	8.12e-06	2.83e-04
Chaperone Mediated Autophagy	19	1.65e-02	4.16e-02	0.40700	0.372000	0.163000	4.96e-03	2.17e-01
Signaling by NTRKs	114	1.11e-08	1.01e-07	0.40600	0.252000	0.319000	3.49e-06	3.89e-09
Notch-HLH transcription pathway	28	1.08e-03	3.71e-03	0.40600	0.132000	0.384000	2.28e-01	4.30e-04
Frs2-mediated activation	11	9.96e-02	1.68e-01	0.40600	0.171000	0.369000	3.27e-01	3.42e-02
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	78	4.80e-06	2.77e-05	0.40500	0.262000	0.310000	6.46e-05	2.25e-06
Programmed Cell Death	179	4.51e-13	1.25e-11	0.40500	0.317000	0.252000	2.46e-13	5.87e-09
Platelet activation, signaling and aggregation	219	1.75e-18	1.03e-16	0.40500	0.196000	0.354000	5.63e-07	1.72e-19
Constitutive Signaling by Overexpressed ERBB2	11	1.74e-01	2.61e-01	0.40300	0.318000	0.248000	6.82e-02	1.54e-01
Signaling by NTRK1 (TRKA)	100	1.61e-07	1.22e-06	0.40100	0.249000	0.314000	1.62e-05	5.52e-08
Role of phospholipids in phagocytosis	87	3.75e-17	1.89e-15	0.40100	0.054400	-0.397000	3.81e-01	1.45e-10
Nucleobase catabolism	28	5.68e-03	1.63e-02	0.40100	0.351000	0.195000	1.32e-03	7.44e-02
MAPK targets/ Nuclear events mediated by MAP kinases	31	8.38e-03	2.33e-02	0.40100	0.257000	0.308000	1.34e-02	3.01e-03
Signaling by Insulin receptor	59	1.38e-04	5.83e-04	0.40000	0.271000	0.294000	3.14e-04	9.30e-05
Processing of SMDT1	15	9.49e-03	2.58e-02	0.40000	0.396000	0.056800	7.92e-03	7.03e-01
Negative regulation of FGFR3 signaling	20	4.60e-02	9.18e-02	0.40000	0.255000	0.308000	4.83e-02	1.71e-02
Fanconi Anemia Pathway	36	2.72e-03	8.55e-03	0.40000	-0.228000	-0.329000	1.80e-02	6.41e-04
Assembly of the pre-replicative complex	66	5.29e-06	3.04e-05	0.40000	0.350000	0.193000	8.60e-07	6.64e-03
Syndecan interactions	19	4.85e-02	9.61e-02	0.40000	0.321000	0.238000	1.55e-02	7.22e-02
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	9.59e-04	3.35e-03	0.39900	-0.075300	-0.392000	5.23e-01	8.80e-04
Signaling by cytosolic FGFR1 fusion mutants	17	7.77e-02	1.38e-01	0.39900	0.294000	0.270000	3.60e-02	5.37e-02
AKT phosphorylates targets in the nucleus	10	6.38e-02	1.20e-01	0.39900	-0.389000	-0.088100	3.32e-02	6.29e-01
Biosynthesis of specialized proresolving mediators (SPMs)	16	7.39e-02	1.33e-01	0.39700	0.328000	0.225000	2.33e-02	1.20e-01
Formation of tubulin folding intermediates by CCT/TriC	22	2.62e-02	5.82e-02	0.39700	0.332000	0.218000	7.10e-03	7.67e-02
Activation of G protein gated Potassium channels	20	1.88e-02	4.51e-02	0.39700	0.359000	0.168000	5.40e-03	1.94e-01
G protein gated Potassium channels	20	1.88e-02	4.51e-02	0.39700	0.359000	0.168000	5.40e-03	1.94e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	20	1.88e-02	4.51e-02	0.39700	0.359000	0.168000	5.40e-03	1.94e-01
ABC-family proteins mediated transport	92	4.57e-07	3.23e-06	0.39600	0.322000	0.230000	8.95e-08	1.33e-04
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	3.59e-03	1.09e-02	0.39500	0.223000	0.326000	2.24e-02	8.51e-04
Interleukin-12 family signaling	53	1.30e-04	5.51e-04	0.39300	0.336000	0.205000	2.34e-05	9.85e-03
Apoptosis	167	1.27e-11	2.75e-10	0.39300	0.309000	0.243000	5.41e-12	5.84e-08
Interferon alpha/beta signaling	57	5.28e-05	2.50e-04	0.39300	-0.198000	-0.340000	9.69e-03	9.10e-06
Clathrin-mediated endocytosis	125	1.01e-10	1.61e-09	0.39200	0.179000	0.349000	5.66e-04	1.52e-11
Signaling by EGFR in Cancer	22	4.04e-02	8.29e-02	0.39100	0.256000	0.296000	3.77e-02	1.62e-02
Macroautophagy	109	1.67e-07	1.27e-06	0.39100	0.268000	0.285000	1.36e-06	2.80e-07
O-glycosylation of TSR domain-containing proteins	25	2.79e-02	6.14e-02	0.39000	-0.267000	-0.285000	2.10e-02	1.37e-02
FRS-mediated FGFR4 signaling	12	9.35e-02	1.60e-01	0.38900	0.356000	0.156000	3.27e-02	3.49e-01
PCNA-Dependent Long Patch Base Excision Repair	21	5.45e-04	2.04e-03	0.38800	0.006030	-0.388000	9.62e-01	2.08e-03
Asparagine N-linked glycosylation	269	1.43e-17	7.80e-16	0.38700	0.243000	0.302000	7.07e-12	1.48e-17
Membrane Trafficking	555	5.19e-40	1.77e-37	0.38700	0.197000	0.333000	2.01e-15	3.07e-41
Diseases of carbohydrate metabolism	29	1.70e-02	4.25e-02	0.38600	0.260000	0.286000	1.55e-02	7.78e-03
VxPx cargo-targeting to cilium	19	1.86e-02	4.51e-02	0.38500	0.135000	0.361000	3.07e-01	6.50e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	6.18e-02	1.16e-01	0.38500	0.320000	0.214000	1.88e-02	1.15e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	6.18e-02	1.16e-01	0.38500	0.320000	0.214000	1.88e-02	1.15e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	6.38e-04	2.34e-03	0.38500	0.294000	0.248000	2.46e-04	1.96e-03
Glycogen metabolism	23	3.50e-02	7.36e-02	0.38500	0.234000	0.305000	5.21e-02	1.13e-02
Interleukin-4 and Interleukin-13 signaling	92	4.35e-07	3.11e-06	0.38400	0.326000	0.203000	6.31e-08	7.44e-04
Acyl chain remodelling of PI	10	1.56e-01	2.39e-01	0.38400	0.164000	0.348000	3.70e-01	5.69e-02
Protein ubiquitination	72	3.73e-05	1.82e-04	0.38400	0.244000	0.296000	3.44e-04	1.38e-05
Mitotic Telophase/Cytokinesis	13	1.17e-01	1.91e-01	0.38300	0.191000	0.331000	2.33e-01	3.85e-02
Oncogenic MAPK signaling	73	2.88e-05	1.43e-04	0.38100	0.230000	0.304000	6.84e-04	7.29e-06
Cleavage of the damaged purine	24	4.05e-03	1.21e-02	0.38100	0.106000	0.366000	3.68e-01	1.93e-03
Depurination	24	4.05e-03	1.21e-02	0.38100	0.106000	0.366000	3.68e-01	1.93e-03
Recognition and association of DNA glycosylase with site containing an affected purine	24	4.05e-03	1.21e-02	0.38100	0.106000	0.366000	3.68e-01	1.93e-03
SHC1 events in ERBB2 signaling	17	9.93e-02	1.67e-01	0.38000	0.275000	0.262000	4.95e-02	6.10e-02
Heme degradation	10	2.29e-01	3.22e-01	0.38000	0.218000	0.311000	2.33e-01	8.85e-02
Formation of Fibrin Clot (Clotting Cascade)	26	2.86e-02	6.24e-02	0.37700	0.240000	0.290000	3.38e-02	1.04e-02
Processing and activation of SUMO	10	2.50e-01	3.44e-01	0.37700	0.295000	0.234000	1.06e-01	2.00e-01
Trafficking and processing of endosomal TLR	13	1.53e-01	2.35e-01	0.37600	0.307000	0.217000	5.49e-02	1.76e-01
Gap junction trafficking and regulation	15	9.39e-02	1.60e-01	0.37600	0.190000	0.324000	2.03e-01	2.96e-02
Endogenous sterols	16	1.22e-01	1.97e-01	0.37400	0.269000	0.260000	6.25e-02	7.18e-02
HDACs deacetylate histones	47	4.33e-06	2.51e-05	0.37300	0.059700	0.368000	4.79e-01	1.26e-05
Orc1 removal from chromatin	69	3.05e-06	1.82e-05	0.37200	0.343000	0.144000	8.55e-07	3.80e-02
Caspase activation via extrinsic apoptotic signalling pathway	25	3.13e-02	6.75e-02	0.37100	0.300000	0.218000	9.36e-03	5.93e-02
Interleukin-15 signaling	14	1.22e-01	1.97e-01	0.37100	0.317000	0.193000	4.01e-02	2.12e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	2.37e-01	3.31e-01	0.37100	0.244000	0.279000	1.61e-01	1.09e-01
Toll Like Receptor 3 (TLR3) Cascade	92	6.90e-06	3.89e-05	0.37100	0.251000	0.273000	3.11e-05	6.18e-06
Cargo recognition for clathrin-mediated endocytosis	88	9.06e-07	6.09e-06	0.36900	0.175000	0.324000	4.43e-03	1.42e-07
Interleukin-10 signaling	35	1.62e-03	5.35e-03	0.36900	0.341000	0.140000	4.81e-04	1.52e-01
Regulation of Complement cascade	93	1.30e-19	9.59e-18	0.36600	0.174000	-0.322000	3.80e-03	7.80e-08
TNFR2 non-canonical NF-kB pathway	95	6.89e-10	8.24e-09	0.36500	0.354000	0.089200	2.46e-09	1.33e-01
Synthesis of PIPs at the late endosome membrane	11	1.25e-01	2.00e-01	0.36500	0.127000	0.342000	4.65e-01	4.95e-02
Beta-catenin phosphorylation cascade	17	4.81e-02	9.55e-02	0.36400	0.139000	0.336000	3.21e-01	1.64e-02
Cyclin E associated events during G1/S transition	83	7.39e-06	4.08e-05	0.36300	0.308000	0.192000	1.18e-06	2.54e-03
Negative regulation of FGFR1 signaling	24	3.93e-02	8.14e-02	0.36300	0.207000	0.298000	7.93e-02	1.16e-02
Cell-extracellular matrix interactions	14	1.45e-01	2.27e-01	0.36300	0.200000	0.302000	1.94e-01	5.04e-02
Negative regulation of FGFR4 signaling	21	7.25e-02	1.31e-01	0.36200	0.238000	0.273000	5.92e-02	3.01e-02
GRB2 events in ERBB2 signaling	11	1.87e-01	2.75e-01	0.36200	0.318000	0.173000	6.77e-02	3.19e-01
Activation of BAD and translocation to mitochondria	15	1.51e-01	2.33e-01	0.36200	0.278000	0.232000	6.23e-02	1.20e-01
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.15e-01	1.89e-01	0.36200	0.113000	0.343000	5.16e-01	4.86e-02
Signaling by Interleukins	385	3.30e-21	3.00e-19	0.36100	0.274000	0.235000	2.66e-20	2.17e-15
Defective B3GALTL causes Peters-plus syndrome (PpS)	24	5.28e-02	1.02e-01	0.36100	-0.248000	-0.263000	3.56e-02	2.60e-02
Synthesis of PC	23	5.41e-02	1.05e-01	0.36100	0.282000	0.225000	1.91e-02	6.18e-02
G beta:gamma signalling through BTK	15	1.56e-01	2.38e-01	0.36000	0.274000	0.234000	6.63e-02	1.17e-01
Intra-Golgi and retrograde Golgi-to-ER traffic	179	1.84e-11	3.76e-10	0.36000	0.192000	0.304000	8.89e-06	2.15e-12
FCERI mediated Ca+2 mobilization	88	1.90e-14	6.96e-13	0.36000	0.058600	-0.355000	3.42e-01	8.57e-09
Binding and Uptake of Ligands by Scavenger Receptors	91	2.01e-19	1.30e-17	0.36000	0.214000	-0.289000	4.13e-04	1.92e-06
Aggrephagy	21	8.01e-02	1.41e-01	0.35800	0.258000	0.248000	4.09e-02	4.90e-02
FGFR1 mutant receptor activation	23	6.22e-02	1.17e-01	0.35800	0.264000	0.241000	2.84e-02	4.50e-02
Selective autophagy	57	1.04e-03	3.58e-03	0.35800	0.264000	0.241000	5.67e-04	1.63e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	36	1.22e-02	3.20e-02	0.35800	0.274000	0.230000	4.51e-03	1.68e-02
TP53 Regulates Metabolic Genes	85	3.89e-05	1.89e-04	0.35700	0.255000	0.250000	4.67e-05	6.84e-05
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	9.12e-02	1.57e-01	0.35600	0.197000	0.297000	1.48e-01	2.92e-02
Intrinsic Pathway of Fibrin Clot Formation	16	1.49e-01	2.31e-01	0.35600	0.260000	0.243000	7.22e-02	9.19e-02
Complement cascade	97	2.43e-19	1.51e-17	0.35600	0.169000	-0.313000	3.96e-03	1.00e-07
Caspase activation via Death Receptors in the presence of ligand	16	4.15e-02	8.49e-02	0.35500	0.341000	0.101000	1.83e-02	4.86e-01
E3 ubiquitin ligases ubiquitinate target proteins	52	1.57e-03	5.21e-03	0.35500	0.216000	0.282000	7.15e-03	4.36e-04
Purine ribonucleoside monophosphate biosynthesis	10	9.57e-03	2.60e-02	0.35400	0.270000	-0.229000	1.39e-01	2.11e-01
Signaling by NOTCH	182	1.21e-10	1.92e-09	0.35300	0.205000	0.287000	1.83e-06	2.25e-11
Signaling by SCF-KIT	40	8.51e-03	2.34e-02	0.35300	0.270000	0.227000	3.11e-03	1.31e-02
Signaling by EGFR	45	9.88e-04	3.42e-03	0.35200	0.153000	0.317000	7.52e-02	2.31e-04
G-protein activation	23	6.81e-02	1.26e-01	0.35200	0.258000	0.239000	3.19e-02	4.71e-02
Metabolism of porphyrins	22	6.05e-02	1.15e-01	0.35000	0.196000	0.290000	1.11e-01	1.84e-02
HDMs demethylate histones	22	4.72e-05	2.26e-04	0.34900	-0.228000	0.265000	6.42e-02	3.16e-02
Nucleobase biosynthesis	13	3.62e-03	1.10e-02	0.34900	0.176000	-0.302000	2.73e-01	5.94e-02
Signaling by Erythropoietin	24	3.53e-02	7.42e-02	0.34900	0.170000	0.305000	1.50e-01	9.79e-03
G-protein beta:gamma signalling	29	1.95e-02	4.62e-02	0.34800	0.175000	0.301000	1.03e-01	5.01e-03
Pexophagy	11	2.81e-01	3.79e-01	0.34800	0.227000	0.264000	1.92e-01	1.30e-01
Glutathione conjugation	26	3.03e-02	6.59e-02	0.34800	0.300000	0.177000	8.19e-03	1.18e-01
Mitochondrial calcium ion transport	22	1.50e-02	3.82e-02	0.34700	0.333000	0.097400	6.77e-03	4.29e-01
TRAF6 mediated NF-kB activation	23	6.80e-02	1.26e-01	0.34700	0.218000	0.270000	6.98e-02	2.49e-02
Regulation of TP53 Activity through Association with Co-factors	12	2.47e-01	3.40e-01	0.34600	-0.270000	-0.217000	1.05e-01	1.93e-01
Telomere C-strand (Lagging Strand) Synthesis	34	1.14e-03	3.88e-03	0.34600	-0.085600	-0.336000	3.88e-01	7.08e-04
Signaling by FGFR3	31	3.15e-02	6.77e-02	0.34500	0.239000	0.249000	2.15e-02	1.65e-02
Deadenylation of mRNA	22	8.32e-02	1.46e-01	0.34400	0.261000	0.224000	3.38e-02	6.91e-02
Interconversion of nucleotide di- and triphosphates	27	5.16e-03	1.51e-02	0.34300	0.332000	0.086300	2.79e-03	4.37e-01
Mitophagy	28	2.20e-02	5.08e-02	0.34300	0.301000	0.164000	5.83e-03	1.33e-01
G beta:gamma signalling through PLC beta	17	1.53e-01	2.35e-01	0.34300	0.248000	0.237000	7.72e-02	9.07e-02
Presynaptic function of Kainate receptors	17	1.53e-01	2.35e-01	0.34300	0.248000	0.237000	7.72e-02	9.07e-02
RHO GTPases activate CIT	18	5.43e-02	1.05e-01	0.34200	0.125000	0.318000	3.60e-01	1.94e-02
Signaling by FGFR4	31	3.31e-02	7.07e-02	0.34200	0.250000	0.233000	1.59e-02	2.48e-02
L1CAM interactions	83	8.42e-06	4.57e-05	0.34200	0.154000	0.305000	1.52e-02	1.57e-06
Cytosolic tRNA aminoacylation	24	1.78e-03	5.85e-03	0.34200	0.341000	0.008680	3.79e-03	9.41e-01
GPVI-mediated activation cascade	31	1.47e-03	4.95e-03	0.34100	0.064600	0.335000	5.33e-01	1.26e-03
Resolution of Abasic Sites (AP sites)	37	2.25e-03	7.19e-03	0.34000	-0.118000	-0.319000	2.14e-01	7.81e-04
Plasma lipoprotein clearance	28	4.08e-02	8.36e-02	0.33900	0.203000	0.271000	6.27e-02	1.29e-02
Thrombin signalling through proteinase activated receptors (PARs)	27	4.43e-02	8.91e-02	0.33800	0.198000	0.274000	7.46e-02	1.36e-02
Surfactant metabolism	22	9.40e-02	1.60e-01	0.33700	0.250000	0.227000	4.24e-02	6.58e-02
Glucagon signaling in metabolic regulation	27	4.87e-02	9.61e-02	0.33700	0.206000	0.267000	6.41e-02	1.63e-02
Rab regulation of trafficking	120	7.18e-09	6.57e-08	0.33700	0.124000	0.314000	1.94e-02	2.93e-09
p75NTR signals via NF-kB	15	1.61e-01	2.45e-01	0.33700	0.285000	0.180000	5.62e-02	2.27e-01
SHC-mediated cascade:FGFR4	10	1.17e-01	1.91e-01	0.33600	0.332000	0.052700	6.93e-02	7.73e-01
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	83	5.94e-11	1.04e-09	0.33600	0.022600	-0.335000	7.21e-01	1.29e-07
N-Glycan antennae elongation	13	2.55e-02	5.71e-02	0.33500	-0.334000	0.021700	3.68e-02	8.92e-01
PPARA activates gene expression	104	1.11e-07	8.72e-07	0.33500	0.123000	0.311000	2.96e-02	4.06e-08
Costimulation by the CD28 family	74	2.41e-04	9.61e-04	0.33500	-0.196000	-0.271000	3.52e-03	5.52e-05
p38MAPK events	13	2.35e-01	3.29e-01	0.33500	0.268000	0.201000	9.47e-02	2.10e-01
TICAM1, RIP1-mediated IKK complex recruitment	19	1.27e-01	2.01e-01	0.33400	0.261000	0.209000	4.86e-02	1.15e-01
FCGR3A-mediated IL10 synthesis	98	8.68e-14	2.75e-12	0.33400	0.052100	-0.330000	3.72e-01	1.69e-08
Cyclin A:Cdk2-associated events at S phase entry	85	3.17e-05	1.55e-04	0.33300	0.286000	0.172000	5.32e-06	6.07e-03
Signaling by FGFR2 IIIa TM	18	1.34e-01	2.12e-01	0.33200	0.270000	0.193000	4.71e-02	1.57e-01
Beta-oxidation of very long chain fatty acids	10	3.23e-01	4.18e-01	0.33100	0.187000	0.273000	3.05e-01	1.35e-01
Uptake and actions of bacterial toxins	27	6.00e-02	1.14e-01	0.33100	0.250000	0.217000	2.47e-02	5.07e-02
Nuclear Events (kinase and transcription factor activation)	53	2.26e-03	7.21e-03	0.33100	0.181000	0.276000	2.24e-02	4.98e-04
Sphingolipid de novo biosynthesis	42	1.09e-02	2.90e-02	0.33000	0.200000	0.263000	2.51e-02	3.20e-03
Endosomal/Vacuolar pathway	12	2.82e-01	3.80e-01	0.33000	-0.208000	-0.256000	2.12e-01	1.24e-01
RA biosynthesis pathway	13	1.86e-01	2.73e-01	0.33000	-0.152000	-0.293000	3.41e-01	6.77e-02
Switching of origins to a post-replicative state	89	2.22e-06	1.37e-05	0.33000	0.305000	0.126000	6.67e-07	4.06e-02
Signalling to RAS	18	8.88e-02	1.53e-01	0.32900	0.296000	0.142000	2.95e-02	2.96e-01
Striated Muscle Contraction	24	8.71e-02	1.51e-01	0.32800	0.244000	0.219000	3.85e-02	6.31e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	21	3.78e-02	7.87e-02	0.32800	0.110000	0.309000	3.83e-01	1.43e-02
UCH proteinases	86	1.71e-04	7.08e-04	0.32800	0.222000	0.241000	3.70e-04	1.13e-04
Pre-NOTCH Expression and Processing	65	4.84e-07	3.40e-06	0.32800	0.028700	0.326000	6.89e-01	5.36e-06
Metabolism of steroid hormones	19	1.01e-01	1.69e-01	0.32800	0.284000	0.163000	3.21e-02	2.18e-01
Signaling by Non-Receptor Tyrosine Kinases	47	3.38e-03	1.04e-02	0.32700	0.161000	0.284000	5.55e-02	7.49e-04
Signaling by PTK6	47	3.38e-03	1.04e-02	0.32700	0.161000	0.284000	5.55e-02	7.49e-04
Transcriptional regulation by RUNX2	99	2.91e-05	1.44e-04	0.32700	0.261000	0.197000	7.28e-06	7.17e-04
Chondroitin sulfate biosynthesis	12	2.33e-01	3.26e-01	0.32700	0.161000	0.284000	3.35e-01	8.80e-02
Myogenesis	21	6.49e-02	1.21e-01	0.32600	0.144000	0.292000	2.53e-01	2.04e-02
Diseases of DNA repair	10	3.48e-01	4.43e-01	0.32600	-0.261000	-0.195000	1.53e-01	2.86e-01
Signaling by FGFR1 in disease	30	4.32e-02	8.72e-02	0.32400	0.260000	0.194000	1.37e-02	6.61e-02
COPI-dependent Golgi-to-ER retrograde traffic	78	4.59e-04	1.74e-03	0.32400	0.224000	0.235000	6.32e-04	3.39e-04
Acyl chain remodelling of PG	11	3.21e-01	4.16e-01	0.32300	0.194000	0.258000	2.66e-01	1.39e-01
Transcriptional regulation by RUNX3	90	6.99e-05	3.20e-04	0.32300	0.265000	0.184000	1.41e-05	2.50e-03
A tetrasaccharide linker sequence is required for GAG synthesis	17	1.85e-01	2.73e-01	0.32200	-0.207000	-0.247000	1.40e-01	7.85e-02
ERBB2 Regulates Cell Motility	10	3.33e-01	4.29e-01	0.32100	0.173000	0.271000	3.44e-01	1.39e-01
XBP1(S) activates chaperone genes	47	4.51e-03	1.34e-02	0.32100	0.162000	0.277000	5.44e-02	1.01e-03
Acyl chain remodelling of PC	19	1.52e-01	2.33e-01	0.32100	0.204000	0.248000	1.24e-01	6.15e-02
Hedgehog ‘off’ state	91	1.16e-04	4.99e-04	0.32100	0.250000	0.200000	3.63e-05	9.72e-04
MET promotes cell motility	26	3.65e-02	7.66e-02	0.32000	0.139000	0.289000	2.19e-01	1.09e-02
Pre-NOTCH Transcription and Translation	49	3.38e-05	1.65e-04	0.32000	0.032000	0.318000	6.98e-01	1.15e-04
Homologous DNA Pairing and Strand Exchange	42	2.28e-03	7.27e-03	0.32000	-0.112000	-0.300000	2.09e-01	7.81e-04
FRS-mediated FGFR1 signaling	14	2.25e-01	3.18e-01	0.32000	0.266000	0.178000	8.54e-02	2.48e-01
PKA activation in glucagon signalling	14	7.01e-02	1.29e-01	0.32000	0.055300	0.315000	7.20e-01	4.13e-02
Senescence-Associated Secretory Phenotype (SASP)	66	5.90e-04	2.18e-03	0.31900	0.164000	0.274000	2.16e-02	1.15e-04
Purine salvage	12	2.29e-01	3.22e-01	0.31900	0.285000	0.145000	8.77e-02	3.85e-01
Formation of the cornified envelope	21	1.13e-01	1.86e-01	0.31900	0.261000	0.183000	3.82e-02	1.47e-01
Diseases of programmed cell death	27	7.13e-02	1.30e-01	0.31900	0.203000	0.246000	6.85e-02	2.70e-02
Selenocysteine synthesis	91	1.16e-11	2.55e-10	0.31800	0.046600	-0.315000	4.43e-01	2.04e-07
Metabolism of nucleotides	86	1.33e-06	8.56e-06	0.31800	0.305000	0.092400	1.04e-06	1.38e-01
Integration of energy metabolism	86	1.53e-04	6.38e-04	0.31800	0.185000	0.259000	3.05e-03	3.34e-05
FCERI mediated MAPK activation	89	2.28e-14	7.96e-13	0.31800	0.152000	-0.279000	1.29e-02	5.51e-06
PTEN Regulation	138	1.41e-06	9.04e-06	0.31800	0.198000	0.248000	5.90e-05	4.75e-07
Class C/3 (Metabotropic glutamate/pheromone receptors)	11	1.84e-01	2.72e-01	0.31700	-0.094700	-0.302000	5.86e-01	8.27e-02
RORA activates gene expression	18	5.02e-03	1.47e-02	0.31600	-0.070800	0.308000	6.03e-01	2.36e-02
Vesicle-mediated transport	644	5.08e-27	8.66e-25	0.31600	0.200000	0.245000	4.78e-18	2.49e-26
Eukaryotic Translation Elongation	92	2.03e-12	5.22e-11	0.31600	0.070800	-0.308000	2.40e-01	3.33e-07
Peptide chain elongation	87	1.87e-11	3.76e-10	0.31500	0.061700	-0.309000	3.20e-01	6.31e-07
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	5.80e-02	1.11e-01	0.31500	0.313000	-0.031900	7.21e-02	8.55e-01
Downstream signaling of activated FGFR3	16	1.59e-01	2.43e-01	0.31400	0.276000	0.150000	5.58e-02	2.98e-01
TBC/RABGAPs	45	4.21e-04	1.61e-03	0.31400	0.067000	0.307000	4.37e-01	3.66e-04
RNA Pol II CTD phosphorylation and interaction with CE	27	6.08e-02	1.15e-01	0.31400	0.173000	0.262000	1.20e-01	1.83e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	6.08e-02	1.15e-01	0.31400	0.173000	0.262000	1.20e-01	1.83e-02
Intra-Golgi traffic	43	9.12e-04	3.21e-03	0.31400	0.079100	0.304000	3.69e-01	5.64e-04
Sema4D in semaphorin signaling	22	2.53e-02	5.68e-02	0.31300	0.072500	0.305000	5.56e-01	1.34e-02
Regulation of lipid metabolism by PPARalpha	106	4.43e-07	3.15e-06	0.31200	0.109000	0.293000	5.23e-02	1.91e-07
Metalloprotease DUBs	21	1.32e-01	2.09e-01	0.31200	0.187000	0.249000	1.37e-01	4.79e-02
SIRT1 negatively regulates rRNA expression	24	9.33e-02	1.60e-01	0.31200	0.180000	0.254000	1.26e-01	3.10e-02
Beta-catenin independent WNT signaling	136	3.30e-06	1.96e-05	0.31100	0.197000	0.240000	7.20e-05	1.29e-06
Mitochondrial biogenesis	88	3.60e-04	1.39e-03	0.31000	0.221000	0.217000	3.29e-04	4.22e-04
Diseases associated with O-glycosylation of proteins	47	1.11e-02	2.95e-02	0.31000	-0.249000	-0.184000	3.13e-03	2.87e-02
Inwardly rectifying K+ channels	24	5.97e-02	1.14e-01	0.30900	0.278000	0.136000	1.86e-02	2.47e-01
Elevation of cytosolic Ca2+ levels	12	1.46e-02	3.73e-02	0.30900	-0.242000	0.192000	1.47e-01	2.49e-01
NOD1/2 Signaling Pathway	32	5.28e-02	1.02e-01	0.30900	0.239000	0.195000	1.93e-02	5.57e-02
SARS-CoV-2 Infection	63	1.82e-03	5.91e-03	0.30900	0.169000	0.258000	2.03e-02	3.95e-04
Signaling by Hedgehog	119	2.16e-05	1.10e-04	0.30800	0.234000	0.201000	1.07e-05	1.48e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	6.02e-04	2.22e-03	0.30800	0.107000	0.289000	1.69e-01	2.10e-04
Signaling by ERBB4	44	1.98e-02	4.67e-02	0.30800	0.213000	0.223000	1.45e-02	1.06e-02
Rap1 signalling	13	2.49e-01	3.42e-01	0.30700	0.152000	0.267000	3.42e-01	9.55e-02
Peroxisomal lipid metabolism	27	8.24e-02	1.45e-01	0.30600	0.243000	0.186000	2.88e-02	9.39e-02
tRNA processing in the mitochondrion	32	3.00e-04	1.18e-03	0.30600	-0.303000	0.041600	2.98e-03	6.84e-01
IRE1alpha activates chaperones	49	6.34e-03	1.80e-02	0.30600	0.157000	0.263000	5.77e-02	1.47e-03
Carnitine metabolism	10	4.16e-01	5.11e-01	0.30600	0.212000	0.220000	2.46e-01	2.28e-01
RIPK1-mediated regulated necrosis	29	1.97e-02	4.64e-02	0.30500	0.288000	0.102000	7.34e-03	3.44e-01
Regulated Necrosis	29	1.97e-02	4.64e-02	0.30500	0.288000	0.102000	7.34e-03	3.44e-01
Regulation of necroptotic cell death	29	1.97e-02	4.64e-02	0.30500	0.288000	0.102000	7.34e-03	3.44e-01
CD28 dependent Vav1 pathway	12	2.41e-01	3.34e-01	0.30400	0.277000	0.126000	9.69e-02	4.51e-01
Interleukin-27 signaling	11	3.83e-01	4.78e-01	0.30400	0.205000	0.224000	2.39e-01	1.98e-01
VEGFA-VEGFR2 Pathway	90	1.94e-05	9.96e-05	0.30400	0.121000	0.278000	4.65e-02	4.95e-06
HIV Transcription Initiation	45	1.89e-02	4.51e-02	0.30400	0.196000	0.232000	2.31e-02	7.04e-03
RNA Polymerase II HIV Promoter Escape	45	1.89e-02	4.51e-02	0.30400	0.196000	0.232000	2.31e-02	7.04e-03
RNA Polymerase II Promoter Escape	45	1.89e-02	4.51e-02	0.30400	0.196000	0.232000	2.31e-02	7.04e-03
RNA Polymerase II Transcription Initiation	45	1.89e-02	4.51e-02	0.30400	0.196000	0.232000	2.31e-02	7.04e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	1.89e-02	4.51e-02	0.30400	0.196000	0.232000	2.31e-02	7.04e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	1.89e-02	4.51e-02	0.30400	0.196000	0.232000	2.31e-02	7.04e-03
Sphingolipid metabolism	78	3.46e-04	1.35e-03	0.30300	0.154000	0.261000	1.90e-02	6.55e-05
Cyclin A/B1/B2 associated events during G2/M transition	24	8.08e-02	1.43e-01	0.30100	0.264000	0.144000	2.52e-02	2.21e-01
Initiation of Nuclear Envelope (NE) Reformation	19	1.80e-01	2.69e-01	0.30100	0.180000	0.241000	1.75e-01	6.88e-02
Regulation of signaling by CBL	18	8.53e-02	1.48e-01	0.30100	0.092800	0.286000	4.96e-01	3.57e-02
Opioid Signalling	75	7.49e-04	2.72e-03	0.30100	0.162000	0.253000	1.50e-02	1.52e-04
FCERI mediated NF-kB activation	136	3.65e-17	1.89e-15	0.30000	0.288000	-0.086100	6.79e-09	8.32e-02
Telomere C-strand synthesis initiation	13	2.25e-01	3.18e-01	0.29900	-0.124000	-0.272000	4.39e-01	8.92e-02
Viral mRNA Translation	87	5.41e-11	9.57e-10	0.29800	0.081200	-0.287000	1.90e-01	3.71e-06
Cholesterol biosynthesis	24	1.35e-01	2.14e-01	0.29800	0.211000	0.210000	7.30e-02	7.48e-02
Signaling by ERBB2 in Cancer	21	1.63e-01	2.48e-01	0.29800	0.233000	0.186000	6.47e-02	1.41e-01
Oxidative Stress Induced Senescence	79	1.79e-04	7.36e-04	0.29800	0.130000	0.268000	4.59e-02	3.88e-05
GABA receptor activation	36	4.44e-02	8.91e-02	0.29800	0.234000	0.184000	1.51e-02	5.64e-02
Plasma lipoprotein assembly, remodeling, and clearance	52	8.22e-03	2.29e-02	0.29700	0.165000	0.247000	3.95e-02	2.02e-03
Condensation of Prophase Chromosomes	29	4.96e-02	9.70e-02	0.29700	0.139000	0.262000	1.94e-01	1.46e-02
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	181	5.13e-12	1.21e-10	0.29600	-0.075100	-0.286000	8.15e-02	2.92e-11
Eukaryotic Translation Termination	91	9.00e-11	1.50e-09	0.29600	0.062800	-0.289000	3.01e-01	1.85e-06
Glycerophospholipid biosynthesis	106	1.72e-04	7.10e-04	0.29600	0.213000	0.205000	1.50e-04	2.67e-04
Listeria monocytogenes entry into host cells	17	2.47e-01	3.40e-01	0.29600	0.201000	0.217000	1.51e-01	1.22e-01
Mitochondrial protein import	64	5.86e-05	2.75e-04	0.29500	0.288000	0.063100	6.57e-05	3.83e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	2.45e-01	3.38e-01	0.29500	0.173000	0.239000	2.32e-01	9.73e-02
Activation of GABAB receptors	31	7.43e-02	1.33e-01	0.29500	0.228000	0.187000	2.81e-02	7.14e-02
GABA B receptor activation	31	7.43e-02	1.33e-01	0.29500	0.228000	0.187000	2.81e-02	7.14e-02
NOTCH1 Intracellular Domain Regulates Transcription	44	2.31e-02	5.28e-02	0.29500	0.179000	0.234000	3.98e-02	7.18e-03
Mitochondrial translation	97	4.02e-07	2.90e-06	0.29500	0.288000	0.062300	9.55e-07	2.89e-01
Metabolism of folate and pterines	16	2.11e-01	3.03e-01	0.29400	0.255000	0.148000	7.79e-02	3.07e-01
mRNA Capping	29	9.17e-02	1.57e-01	0.29400	0.193000	0.222000	7.28e-02	3.81e-02
Leading Strand Synthesis	14	4.72e-02	9.39e-02	0.29300	0.021200	-0.293000	8.91e-01	5.80e-02
Polymerase switching	14	4.72e-02	9.39e-02	0.29300	0.021200	-0.293000	8.91e-01	5.80e-02
rRNA processing in the mitochondrion	29	9.05e-03	2.48e-02	0.29300	-0.289000	-0.046200	7.09e-03	6.67e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling	40	3.06e-02	6.65e-02	0.29300	0.168000	0.239000	6.52e-02	8.87e-03
Signaling by NTRK2 (TRKB)	20	1.63e-01	2.48e-01	0.29200	0.245000	0.158000	5.74e-02	2.21e-01
NS1 Mediated Effects on Host Pathways	40	1.92e-02	4.58e-02	0.29200	-0.139000	-0.256000	1.27e-01	5.03e-03
Rev-mediated nuclear export of HIV RNA	35	1.30e-02	3.37e-02	0.29100	-0.096000	-0.275000	3.26e-01	4.87e-03
Sema4D induced cell migration and growth-cone collapse	19	1.01e-01	1.69e-01	0.29100	0.101000	0.273000	4.47e-01	3.93e-02
Interactions of Rev with host cellular proteins	37	6.24e-03	1.77e-02	0.29100	-0.077000	-0.281000	4.18e-01	3.13e-03
Cleavage of the damaged pyrimidine	29	1.79e-02	4.42e-02	0.29100	0.074900	0.281000	4.85e-01	8.76e-03
Depyrimidination	29	1.79e-02	4.42e-02	0.29100	0.074900	0.281000	4.85e-01	8.76e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	29	1.79e-02	4.42e-02	0.29100	0.074900	0.281000	4.85e-01	8.76e-03
PIWI-interacting RNA (piRNA) biogenesis	24	8.71e-03	2.39e-02	0.29100	0.291000	-0.000729	1.37e-02	9.95e-01
rRNA modification in the nucleus and cytosol	59	2.54e-06	1.56e-05	0.29000	0.027300	-0.289000	7.17e-01	1.22e-04
Zinc transporters	14	2.92e-01	3.89e-01	0.28900	0.242000	0.159000	1.18e-01	3.03e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	32	6.26e-02	1.17e-01	0.28900	0.162000	0.239000	1.13e-01	1.91e-02
Phosphorylation of the APC/C	20	9.46e-02	1.61e-01	0.28800	0.270000	0.101000	3.65e-02	4.36e-01
Nuclear import of Rev protein	34	1.30e-02	3.37e-02	0.28800	-0.085200	-0.275000	3.90e-01	5.52e-03
Signaling by Receptor Tyrosine Kinases	408	6.64e-17	3.23e-15	0.28800	0.144000	0.249000	5.50e-07	6.16e-18
Metabolism of cofactors	19	2.03e-01	2.95e-01	0.28700	0.235000	0.165000	7.66e-02	2.13e-01
Presynaptic phase of homologous DNA pairing and strand exchange	39	5.52e-03	1.60e-02	0.28700	-0.075800	-0.277000	4.13e-01	2.79e-03
Peptide hormone metabolism	49	1.33e-03	4.50e-03	0.28700	0.277000	0.072500	7.88e-04	3.80e-01
Degradation of the extracellular matrix	78	2.80e-04	1.11e-03	0.28600	0.118000	0.261000	7.11e-02	6.87e-05
APC/C:Cdc20 mediated degradation of Cyclin B	24	4.91e-02	9.65e-02	0.28600	0.273000	0.085400	2.07e-02	4.69e-01
Signaling by NOTCH1	66	3.25e-03	1.00e-02	0.28600	0.154000	0.241000	3.01e-02	7.25e-04
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	31	3.08e-02	6.66e-02	0.28500	-0.105000	-0.265000	3.13e-01	1.05e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	31	3.08e-02	6.66e-02	0.28500	-0.105000	-0.265000	3.13e-01	1.05e-02
Retrograde transport at the Trans-Golgi-Network	49	5.65e-03	1.63e-02	0.28500	0.115000	0.261000	1.64e-01	1.59e-03
Activation of gene expression by SREBF (SREBP)	42	5.03e-03	1.47e-02	0.28500	0.083100	0.273000	3.51e-01	2.24e-03
Chaperonin-mediated protein folding	84	1.54e-03	5.14e-03	0.28500	0.186000	0.216000	3.20e-03	6.34e-04
SUMOylation of transcription factors	16	1.66e-01	2.52e-01	0.28500	0.104000	0.265000	4.72e-01	6.65e-02
Protein methylation	15	3.20e-01	4.16e-01	0.28400	0.205000	0.197000	1.69e-01	1.87e-01
Synthesis of very long-chain fatty acyl-CoAs	21	2.00e-01	2.92e-01	0.28400	0.213000	0.188000	9.08e-02	1.36e-01
Mitochondrial translation termination	91	1.20e-06	7.90e-06	0.28400	0.280000	0.048600	3.93e-06	4.23e-01
Biosynthesis of DHA-derived SPMs	14	2.74e-01	3.71e-01	0.28400	0.248000	0.138000	1.08e-01	3.72e-01
Vasopressin regulates renal water homeostasis via Aquaporins	34	7.54e-02	1.35e-01	0.28300	0.189000	0.211000	5.66e-02	3.29e-02
FGFR2 alternative splicing	25	9.80e-02	1.66e-01	0.28300	0.249000	0.136000	3.15e-02	2.39e-01
Ub-specific processing proteases	169	2.78e-06	1.67e-05	0.28300	0.213000	0.186000	1.70e-06	3.02e-05
p75NTR recruits signalling complexes	12	3.53e-01	4.48e-01	0.28200	0.241000	0.148000	1.49e-01	3.75e-01
Transport of bile salts and organic acids, metal ions and amine compounds	55	1.17e-02	3.09e-02	0.28200	0.163000	0.230000	3.60e-02	3.15e-03
Nuclear signaling by ERBB4	24	1.15e-01	1.89e-01	0.28200	0.140000	0.245000	2.36e-01	3.75e-02
Formation of the Early Elongation Complex	33	5.78e-02	1.11e-01	0.28200	0.148000	0.240000	1.41e-01	1.70e-02
Formation of the HIV-1 Early Elongation Complex	33	5.78e-02	1.11e-01	0.28200	0.148000	0.240000	1.41e-01	1.70e-02
TNFs bind their physiological receptors	25	1.50e-03	5.03e-03	0.28200	0.102000	-0.263000	3.76e-01	2.30e-02
Aquaporin-mediated transport	38	5.95e-02	1.14e-01	0.28100	0.194000	0.204000	3.89e-02	2.96e-02
TICAM1,TRAF6-dependent induction of TAK1 complex	11	4.35e-01	5.28e-01	0.28100	0.215000	0.182000	2.18e-01	2.97e-01
Regulation of insulin secretion	60	1.13e-02	2.98e-02	0.28100	0.186000	0.210000	1.26e-02	4.81e-03
Vpr-mediated nuclear import of PICs	34	9.98e-03	2.69e-02	0.28000	-0.062700	-0.273000	5.27e-01	5.81e-03
Mitochondrial translation elongation	91	1.30e-06	8.38e-06	0.28000	0.277000	0.043700	5.00e-06	4.71e-01
Downstream signaling of activated FGFR4	17	1.85e-01	2.73e-01	0.27900	0.254000	0.117000	7.02e-02	4.05e-01
RNA Polymerase I Promoter Escape	44	3.77e-02	7.87e-02	0.27900	0.180000	0.213000	3.92e-02	1.43e-02
rRNA processing in the nucleus and cytosol	189	1.34e-19	9.59e-18	0.27900	0.066100	-0.271000	1.17e-01	1.30e-10
Metabolism of amine-derived hormones	10	7.95e-02	1.40e-01	0.27800	0.102000	-0.258000	5.77e-01	1.57e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	93	1.52e-10	2.25e-09	0.27800	0.087300	-0.263000	1.46e-01	1.13e-05
EPHA-mediated growth cone collapse	13	3.20e-01	4.16e-01	0.27700	0.136000	0.242000	3.96e-01	1.31e-01
Mitochondrial translation initiation	91	2.72e-06	1.64e-05	0.27700	0.273000	0.050000	6.89e-06	4.10e-01
Apoptotic execution phase	45	1.87e-02	4.51e-02	0.27700	0.134000	0.243000	1.20e-01	4.85e-03
Glycosphingolipid metabolism	36	2.09e-02	4.88e-02	0.27700	0.099200	0.259000	3.03e-01	7.22e-03
Platelet homeostasis	67	7.04e-04	2.57e-03	0.27600	0.096400	0.259000	1.72e-01	2.45e-04
Major pathway of rRNA processing in the nucleolus and cytosol	179	2.42e-18	1.38e-16	0.27600	0.066800	-0.268000	1.23e-01	6.03e-10
Signaling by ERBB2 TMD/JMD mutants	17	2.39e-01	3.33e-01	0.27600	0.237000	0.142000	9.06e-02	3.12e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	1.82e-01	2.70e-01	0.27500	-0.274000	-0.028400	1.16e-01	8.70e-01
Heme biosynthesis	14	3.23e-01	4.18e-01	0.27500	0.147000	0.232000	3.40e-01	1.33e-01
RHO GTPase Effectors	248	4.73e-10	6.08e-09	0.27400	0.131000	0.241000	3.86e-04	6.23e-11
Cohesin Loading onto Chromatin	10	2.85e-01	3.84e-01	0.27400	0.066500	0.265000	7.16e-01	1.46e-01
HIV Infection	224	6.15e-08	4.93e-07	0.27400	0.220000	0.162000	1.38e-08	2.80e-05
N-glycan antennae elongation in the medial/trans-Golgi	21	1.77e-02	4.40e-02	0.27300	-0.272000	0.023600	3.08e-02	8.51e-01
Formation of a pool of free 40S subunits	99	7.31e-12	1.66e-10	0.27200	0.130000	-0.240000	2.59e-02	3.76e-05
Diseases of signal transduction by growth factor receptors and second messengers	339	1.99e-11	3.94e-10	0.27200	0.163000	0.218000	2.35e-07	5.31e-12
Chemokine receptors bind chemokines	39	2.01e-02	4.72e-02	0.27200	-0.103000	-0.252000	2.67e-01	6.52e-03
Misspliced GSK3beta mutants stabilize beta-catenin	15	1.25e-01	2.00e-01	0.27200	0.045400	0.268000	7.61e-01	7.23e-02
S33 mutants of beta-catenin aren’t phosphorylated	15	1.25e-01	2.00e-01	0.27200	0.045400	0.268000	7.61e-01	7.23e-02
S37 mutants of beta-catenin aren’t phosphorylated	15	1.25e-01	2.00e-01	0.27200	0.045400	0.268000	7.61e-01	7.23e-02
S45 mutants of beta-catenin aren’t phosphorylated	15	1.25e-01	2.00e-01	0.27200	0.045400	0.268000	7.61e-01	7.23e-02
T41 mutants of beta-catenin aren’t phosphorylated	15	1.25e-01	2.00e-01	0.27200	0.045400	0.268000	7.61e-01	7.23e-02
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	15	1.25e-01	2.00e-01	0.27200	0.045400	0.268000	7.61e-01	7.23e-02
Interleukin-6 family signaling	18	2.13e-01	3.05e-01	0.27100	0.239000	0.128000	7.97e-02	3.47e-01
EPH-ephrin mediated repulsion of cells	39	7.00e-02	1.29e-01	0.26900	0.197000	0.184000	3.33e-02	4.73e-02
Regulation of IFNA signaling	12	3.17e-01	4.15e-01	0.26900	0.106000	0.247000	5.25e-01	1.38e-01
Interactions of Vpr with host cellular proteins	37	1.12e-02	2.98e-02	0.26900	-0.064500	-0.261000	4.97e-01	6.04e-03
Protein folding	90	1.90e-03	6.14e-03	0.26900	0.169000	0.209000	5.54e-03	6.22e-04
Response of EIF2AK4 (GCN2) to amino acid deficiency	99	6.63e-11	1.13e-09	0.26900	0.099500	-0.249000	8.70e-02	1.79e-05
Plasma lipoprotein assembly	10	3.41e-01	4.38e-01	0.26900	0.085500	0.255000	6.39e-01	1.63e-01
Base-Excision Repair, AP Site Formation	31	2.38e-02	5.45e-02	0.26800	0.065000	0.260000	5.31e-01	1.22e-02
Signaling by ERBB2 ECD mutants	15	3.19e-01	4.15e-01	0.26800	0.225000	0.146000	1.31e-01	3.28e-01
PLC beta mediated events	43	1.73e-02	4.33e-02	0.26800	0.107000	0.246000	2.26e-01	5.26e-03
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	2.54e-02	5.68e-02	0.26800	0.169000	0.208000	3.33e-02	8.85e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	2.54e-02	5.68e-02	0.26800	0.169000	0.208000	3.33e-02	8.85e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	2.54e-02	5.68e-02	0.26800	0.169000	0.208000	3.33e-02	8.85e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	2.54e-02	5.68e-02	0.26800	0.169000	0.208000	3.33e-02	8.85e-03
Signaling by NOTCH1 in Cancer	53	2.54e-02	5.68e-02	0.26800	0.169000	0.208000	3.33e-02	8.85e-03
Transport of Ribonucleoproteins into the Host Nucleus	32	3.66e-02	7.67e-02	0.26700	-0.089600	-0.252000	3.81e-01	1.38e-02
SLBP independent Processing of Histone Pre-mRNAs	10	1.13e-01	1.86e-01	0.26600	0.256000	-0.073300	1.61e-01	6.88e-01
NGF-stimulated transcription	31	1.15e-01	1.89e-01	0.26600	0.162000	0.211000	1.19e-01	4.18e-02
Signaling by FGFR in disease	50	2.30e-02	5.28e-02	0.26600	0.224000	0.142000	6.07e-03	8.16e-02
Disorders of transmembrane transporters	144	2.81e-05	1.40e-04	0.26600	0.220000	0.149000	5.23e-06	2.02e-03
NRIF signals cell death from the nucleus	15	2.86e-01	3.84e-01	0.26600	0.235000	0.124000	1.15e-01	4.07e-01
SARS-CoV-1 Infection	47	2.33e-02	5.33e-02	0.26500	0.131000	0.231000	1.21e-01	6.15e-03
Signaling by Hippo	18	2.02e-01	2.94e-01	0.26500	0.112000	0.240000	4.11e-01	7.75e-02
Abortive elongation of HIV-1 transcript in the absence of Tat	23	2.07e-01	3.00e-01	0.26500	0.164000	0.208000	1.75e-01	8.39e-02
Translesion synthesis by REV1	16	7.84e-02	1.39e-01	0.26500	-0.005550	-0.264000	9.69e-01	6.70e-02
Prostacyclin signalling through prostacyclin receptor	16	3.19e-01	4.15e-01	0.26400	0.217000	0.152000	1.34e-01	2.94e-01
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.75e-03	8.62e-03	0.26400	-0.110000	0.240000	3.43e-01	3.77e-02
NEP/NS2 Interacts with the Cellular Export Machinery	32	2.27e-02	5.23e-02	0.26400	-0.061600	-0.257000	5.47e-01	1.20e-02
Tie2 Signaling	16	3.33e-01	4.29e-01	0.26300	0.157000	0.211000	2.77e-01	1.45e-01
Cytosolic iron-sulfur cluster assembly	13	1.75e-01	2.62e-01	0.26300	-0.260000	-0.036900	1.04e-01	8.18e-01
Formation of RNA Pol II elongation complex	57	7.07e-03	1.97e-02	0.26200	0.111000	0.238000	1.48e-01	1.90e-03
RNA Polymerase II Transcription Elongation	57	7.07e-03	1.97e-02	0.26200	0.111000	0.238000	1.48e-01	1.90e-03
GP1b-IX-V activation signalling	10	4.14e-01	5.10e-01	0.26200	0.108000	0.239000	5.53e-01	1.91e-01
Transcriptional regulation of white adipocyte differentiation	77	2.08e-04	8.43e-04	0.26200	0.070500	0.252000	2.85e-01	1.30e-04
Metal ion SLC transporters	21	2.53e-01	3.47e-01	0.26000	0.201000	0.165000	1.10e-01	1.90e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	6.94e-06	3.89e-05	0.26000	0.253000	-0.061800	7.78e-04	4.12e-01
Semaphorin interactions	57	1.38e-02	3.55e-02	0.26000	0.132000	0.224000	8.37e-02	3.43e-03
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	32	5.98e-03	1.71e-02	0.26000	-0.003330	0.260000	9.74e-01	1.09e-02
Signaling by ERBB2 KD Mutants	20	2.51e-01	3.45e-01	0.26000	0.213000	0.148000	9.89e-02	2.50e-01
PI3K events in ERBB2 signaling	11	4.93e-01	5.82e-01	0.26000	0.170000	0.196000	3.28e-01	2.60e-01
DNA Replication Pre-Initiation	82	6.89e-05	3.16e-04	0.26000	0.253000	0.056800	7.26e-05	3.74e-01
Assembly of active LPL and LIPC lipase complexes	10	2.02e-01	2.94e-01	0.25900	-0.004810	0.259000	9.79e-01	1.56e-01
Post-chaperonin tubulin folding pathway	19	2.10e-01	3.02e-01	0.25900	0.114000	0.232000	3.89e-01	7.99e-02
MHC class II antigen presentation	101	9.23e-04	3.24e-03	0.25800	0.143000	0.214000	1.31e-02	1.96e-04
Signaling by FGFR1	38	7.73e-02	1.37e-01	0.25700	0.149000	0.210000	1.13e-01	2.49e-02
Translation initiation complex formation	58	7.17e-06	4.01e-05	0.25700	0.246000	-0.074100	1.20e-03	3.29e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	2.16e-01	3.08e-01	0.25500	0.146000	0.209000	2.25e-01	8.22e-02
Selenoamino acid metabolism	113	2.35e-11	4.45e-10	0.25500	0.100000	-0.235000	6.63e-02	1.62e-05
Acetylcholine Neurotransmitter Release Cycle	11	2.97e-01	3.94e-01	0.25500	-0.059800	-0.248000	7.31e-01	1.55e-01
Peroxisomal protein import	57	2.77e-02	6.12e-02	0.25500	0.199000	0.159000	9.48e-03	3.73e-02
The role of Nef in HIV-1 replication and disease pathogenesis	28	1.75e-01	2.62e-01	0.25500	0.163000	0.196000	1.36e-01	7.30e-02
Insulin processing	20	2.93e-01	3.90e-01	0.25500	0.190000	0.169000	1.41e-01	1.90e-01
NCAM1 interactions	23	1.16e-01	1.90e-01	0.25400	-0.085900	-0.240000	4.76e-01	4.67e-02
Protein localization	157	1.36e-05	7.18e-05	0.25400	0.219000	0.129000	2.21e-06	5.18e-03
Formation of TC-NER Pre-Incision Complex	53	3.44e-02	7.26e-02	0.25400	0.155000	0.202000	5.14e-02	1.11e-02
Formation of the ternary complex, and subsequently, the 43S complex	51	6.50e-06	3.68e-05	0.25400	0.209000	-0.144000	9.78e-03	7.49e-02
ESR-mediated signaling	159	8.53e-06	4.61e-05	0.25400	0.124000	0.222000	7.19e-03	1.40e-06
Sialic acid metabolism	28	1.63e-01	2.48e-01	0.25400	0.149000	0.205000	1.73e-01	5.99e-02
Aflatoxin activation and detoxification	14	2.01e-01	2.93e-01	0.25300	0.248000	0.050500	1.08e-01	7.44e-01
RNA polymerase II transcribes snRNA genes	72	8.53e-03	2.35e-02	0.25300	0.142000	0.209000	3.76e-02	2.13e-03
Signaling by PDGFR in disease	19	3.01e-01	3.97e-01	0.25300	0.152000	0.202000	2.50e-01	1.28e-01
Prolactin receptor signaling	11	2.31e-01	3.24e-01	0.25100	0.250000	0.019700	1.51e-01	9.10e-01
Signaling by WNT	253	4.40e-09	4.32e-08	0.25100	0.112000	0.225000	2.23e-03	7.51e-10
Signaling by VEGF	97	1.87e-04	7.64e-04	0.25000	0.087300	0.234000	1.37e-01	6.63e-05
G-protein mediated events	44	2.45e-02	5.56e-02	0.25000	0.095000	0.231000	2.75e-01	7.98e-03
SHC-mediated cascade:FGFR1	12	3.67e-01	4.62e-01	0.24900	0.230000	0.095700	1.67e-01	5.66e-01
Extra-nuclear estrogen signaling	65	2.29e-02	5.27e-02	0.24900	0.173000	0.179000	1.59e-02	1.25e-02
Extension of Telomeres	51	3.11e-03	9.65e-03	0.24900	-0.045500	-0.245000	5.74e-01	2.50e-03
TCF dependent signaling in response to WNT	165	1.85e-05	9.58e-05	0.24800	0.131000	0.211000	3.56e-03	3.07e-06
Ribosomal scanning and start codon recognition	58	1.35e-05	7.15e-05	0.24800	0.236000	-0.076000	1.85e-03	3.17e-01
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	53	1.79e-04	7.36e-04	0.24700	-0.031200	0.245000	6.94e-01	2.07e-03
Postmitotic nuclear pore complex (NPC) reformation	27	7.26e-02	1.31e-01	0.24600	-0.067000	-0.237000	5.46e-01	3.30e-02
Cellular responses to external stimuli	503	1.05e-13	3.19e-12	0.24600	0.198000	0.146000	2.49e-14	2.30e-08
Purine catabolism	16	2.68e-01	3.64e-01	0.24500	0.228000	0.091600	1.15e-01	5.26e-01
RNA Polymerase II Pre-transcription Events	78	5.95e-03	1.70e-02	0.24500	0.128000	0.210000	5.11e-02	1.37e-03
L13a-mediated translational silencing of Ceruloplasmin expression	109	2.64e-11	4.87e-10	0.24500	0.174000	-0.173000	1.66e-03	1.86e-03
Deubiquitination	240	1.26e-06	8.19e-06	0.24500	0.162000	0.184000	1.60e-05	8.53e-07
GTP hydrolysis and joining of the 60S ribosomal subunit	110	2.25e-11	4.33e-10	0.24500	0.172000	-0.174000	1.80e-03	1.60e-03
Intrinsic Pathway for Apoptosis	53	3.00e-02	6.54e-02	0.24500	0.210000	0.126000	8.08e-03	1.14e-01
Hemostasis	542	1.02e-13	3.17e-12	0.24500	0.166000	0.180000	4.31e-11	6.88e-13
IRAK2 mediated activation of TAK1 complex	10	5.64e-01	6.42e-01	0.24500	0.158000	0.187000	3.87e-01	3.06e-01
NoRC negatively regulates rRNA expression	59	2.08e-02	4.88e-02	0.24400	0.125000	0.209000	9.64e-02	5.39e-03
Polymerase switching on the C-strand of the telomere	26	8.24e-02	1.45e-01	0.24400	-0.064900	-0.235000	5.66e-01	3.81e-02
SUMOylation of intracellular receptors	25	2.69e-02	5.98e-02	0.24300	-0.009510	0.243000	9.34e-01	3.53e-02
B-WICH complex positively regulates rRNA expression	44	8.75e-02	1.51e-01	0.24300	0.175000	0.169000	4.51e-02	5.23e-02
Cellular responses to stress	497	3.13e-13	9.09e-12	0.24200	0.196000	0.142000	6.60e-14	5.74e-08
rRNA processing	218	9.52e-15	3.71e-13	0.24200	0.018600	-0.241000	6.36e-01	7.96e-10
Translation	294	4.72e-20	3.78e-18	0.24200	0.241000	-0.024300	1.16e-12	4.74e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	17	1.36e-01	2.16e-01	0.24200	0.240000	0.029200	8.62e-02	8.35e-01
Glutathione synthesis and recycling	10	3.61e-01	4.56e-01	0.24200	0.236000	0.052500	1.96e-01	7.74e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	4.32e-01	5.27e-01	0.24200	0.184000	0.157000	2.17e-01	2.92e-01
AMER1 mutants destabilize the destruction complex	14	2.09e-01	3.00e-01	0.24200	0.036700	0.239000	8.12e-01	1.21e-01
APC truncation mutants have impaired AXIN binding	14	2.09e-01	3.00e-01	0.24200	0.036700	0.239000	8.12e-01	1.21e-01
AXIN missense mutants destabilize the destruction complex	14	2.09e-01	3.00e-01	0.24200	0.036700	0.239000	8.12e-01	1.21e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	14	2.09e-01	3.00e-01	0.24200	0.036700	0.239000	8.12e-01	1.21e-01
Truncations of AMER1 destabilize the destruction complex	14	2.09e-01	3.00e-01	0.24200	0.036700	0.239000	8.12e-01	1.21e-01
truncated APC mutants destabilize the destruction complex	14	2.09e-01	3.00e-01	0.24200	0.036700	0.239000	8.12e-01	1.21e-01
Synthesis, secretion, and deacylation of Ghrelin	11	1.05e-01	1.75e-01	0.24100	0.211000	-0.118000	2.26e-01	4.99e-01
Platelet calcium homeostasis	21	1.08e-02	2.90e-02	0.24100	-0.155000	0.185000	2.19e-01	1.43e-01
Metabolism of nitric oxide: NOS3 activation and regulation	12	5.18e-01	6.05e-01	0.24100	0.163000	0.177000	3.27e-01	2.88e-01
Immune System	1885	3.55e-42	1.61e-39	0.24100	0.182000	0.158000	3.38e-39	8.29e-30
Host Interactions of HIV factors	129	6.55e-05	3.02e-04	0.24100	0.220000	0.097800	1.62e-05	5.52e-02
Triglyceride metabolism	25	2.46e-01	3.39e-01	0.24100	0.151000	0.187000	1.91e-01	1.05e-01
TGF-beta receptor signaling activates SMADs	32	1.06e-01	1.77e-01	0.24000	0.107000	0.215000	2.95e-01	3.55e-02
FOXO-mediated transcription of cell cycle genes	15	2.73e-01	3.70e-01	0.24000	-0.228000	-0.074700	1.27e-01	6.16e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	1.47e-01	2.29e-01	0.23900	0.104000	0.215000	3.49e-01	5.26e-02
SRP-dependent cotranslational protein targeting to membrane	110	8.81e-11	1.48e-09	0.23900	0.187000	-0.149000	6.95e-04	6.94e-03
Negative regulation of NMDA receptor-mediated neuronal transmission	14	3.51e-01	4.46e-01	0.23900	-0.095200	-0.219000	5.38e-01	1.56e-01
SARS-CoV Infections	140	2.03e-04	8.29e-04	0.23900	0.128000	0.202000	9.11e-03	3.80e-05
PKA activation	15	1.06e-01	1.77e-01	0.23800	-0.025900	0.237000	8.62e-01	1.12e-01
Regulation of PTEN gene transcription	59	1.45e-02	3.73e-02	0.23800	0.101000	0.216000	1.81e-01	4.10e-03
Transport of small molecules	554	2.73e-13	8.08e-12	0.23800	0.160000	0.176000	1.31e-10	1.22e-12
Dectin-2 family	19	3.39e-01	4.35e-01	0.23800	0.139000	0.193000	2.94e-01	1.46e-01
Fc epsilon receptor (FCERI) signaling	189	2.09e-11	4.07e-10	0.23700	0.237000	0.000690	1.79e-08	9.87e-01
CD209 (DC-SIGN) signaling	20	3.03e-01	3.99e-01	0.23700	0.199000	0.129000	1.23e-01	3.18e-01
Synthesis of PE	12	2.96e-01	3.93e-01	0.23700	-0.045600	-0.232000	7.85e-01	1.63e-01
Negative regulation of FGFR2 signaling	23	3.02e-01	3.98e-01	0.23500	0.159000	0.173000	1.87e-01	1.51e-01
Metabolism of steroids	116	7.26e-04	2.65e-03	0.23500	0.116000	0.204000	3.10e-02	1.45e-04
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	2.14e-01	3.06e-01	0.23400	-0.124000	-0.199000	2.73e-01	7.93e-02
Class I MHC mediated antigen processing & presentation	347	1.92e-08	1.63e-07	0.23400	0.155000	0.175000	6.89e-07	1.99e-08
Arachidonic acid metabolism	42	1.12e-01	1.85e-01	0.23400	0.178000	0.152000	4.62e-02	8.85e-02
Regulation of PTEN mRNA translation	13	1.81e-01	2.69e-01	0.23400	-0.233000	0.006950	1.45e-01	9.65e-01
Influenza Viral RNA Transcription and Replication	134	3.86e-10	5.10e-09	0.23300	0.056100	-0.227000	2.62e-01	5.91e-06
Estrogen-dependent gene expression	98	7.81e-04	2.82e-03	0.23300	0.089200	0.216000	1.27e-01	2.27e-04
Downstream TCR signaling	100	7.56e-05	3.45e-04	0.23300	0.228000	0.049500	8.29e-05	3.92e-01
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	1.18e-01	1.92e-01	0.23200	0.086800	0.215000	4.19e-01	4.46e-02
Integrin cell surface interactions	52	4.51e-02	9.05e-02	0.23200	0.118000	0.200000	1.42e-01	1.28e-02
Serotonin Neurotransmitter Release Cycle	14	4.74e-01	5.64e-01	0.23200	-0.139000	-0.185000	3.68e-01	2.30e-01
STING mediated induction of host immune responses	15	2.40e-01	3.33e-01	0.23200	0.227000	0.047500	1.29e-01	7.50e-01
Export of Viral Ribonucleoproteins from Nucleus	33	3.39e-02	7.17e-02	0.23100	-0.034600	-0.229000	7.31e-01	2.30e-02
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	2.87e-01	3.85e-01	0.23100	0.204000	0.110000	1.15e-01	3.96e-01
Fatty acid metabolism	150	5.50e-04	2.06e-03	0.23100	0.170000	0.156000	3.20e-04	9.61e-04
Neddylation	217	1.43e-05	7.51e-05	0.23100	0.144000	0.180000	2.52e-04	4.64e-06
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	7.92e-02	1.40e-01	0.23100	0.039600	-0.227000	7.77e-01	1.05e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	6.50e-02	1.21e-01	0.23000	0.102000	0.207000	2.53e-01	2.04e-02
HIV Transcription Elongation	42	6.50e-02	1.21e-01	0.23000	0.102000	0.207000	2.53e-01	2.04e-02
Tat-mediated elongation of the HIV-1 transcript	42	6.50e-02	1.21e-01	0.23000	0.102000	0.207000	2.53e-01	2.04e-02
Oncogene Induced Senescence	33	4.55e-02	9.11e-02	0.23000	0.047900	0.225000	6.34e-01	2.50e-02
Unfolded Protein Response (UPR)	87	1.35e-02	3.47e-02	0.23000	0.164000	0.161000	8.20e-03	9.27e-03
Regulation of RUNX1 Expression and Activity	18	1.42e-01	2.24e-01	0.23000	-0.229000	-0.023600	9.28e-02	8.62e-01
Vitamin B5 (pantothenate) metabolism	17	4.30e-01	5.25e-01	0.23000	0.162000	0.163000	2.48e-01	2.43e-01
Gap-filling DNA repair synthesis and ligation in GG-NER	25	3.11e-02	6.71e-02	0.23000	0.024400	-0.229000	8.33e-01	4.78e-02
Glyoxylate metabolism and glycine degradation	24	9.84e-02	1.66e-01	0.23000	0.226000	0.042100	5.54e-02	7.21e-01
Cellular Senescence	144	5.04e-05	2.40e-04	0.22900	0.090500	0.210000	6.09e-02	1.33e-05
Cap-dependent Translation Initiation	117	1.50e-10	2.24e-09	0.22900	0.174000	-0.149000	1.17e-03	5.42e-03
Eukaryotic Translation Initiation	117	1.50e-10	2.24e-09	0.22900	0.174000	-0.149000	1.17e-03	5.42e-03
Signaling by FGFR4 in disease	11	3.80e-01	4.76e-01	0.22900	0.222000	0.054900	2.03e-01	7.53e-01
mRNA decay by 3’ to 5’ exoribonuclease	16	9.95e-02	1.68e-01	0.22800	0.035900	-0.226000	8.04e-01	1.18e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	1.51e-03	5.05e-03	0.22700	-0.108000	0.200000	2.61e-01	3.81e-02
Ca-dependent events	29	1.69e-01	2.55e-01	0.22700	0.105000	0.201000	3.29e-01	6.04e-02
HDR through Single Strand Annealing (SSA)	37	6.49e-02	1.21e-01	0.22700	-0.077300	-0.213000	4.16e-01	2.48e-02
Translesion synthesis by POLI	17	9.03e-02	1.55e-01	0.22700	0.034600	-0.224000	8.05e-01	1.10e-01
Metabolism of lipids	619	8.44e-15	3.38e-13	0.22600	0.124000	0.189000	1.28e-07	9.92e-16
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	32	4.87e-03	1.44e-02	0.22600	-0.080400	0.211000	4.31e-01	3.86e-02
cGMP effects	12	3.19e-01	4.15e-01	0.22600	0.038000	0.223000	8.20e-01	1.82e-01
Separation of Sister Chromatids	167	1.07e-04	4.75e-04	0.22600	0.192000	0.119000	1.92e-05	7.95e-03
Elastic fibre formation	31	1.58e-01	2.41e-01	0.22500	0.106000	0.199000	3.06e-01	5.56e-02
G alpha (z) signalling events	36	7.26e-02	1.31e-01	0.22400	0.075700	0.211000	4.32e-01	2.82e-02
Formation of HIV elongation complex in the absence of HIV Tat	44	5.83e-02	1.12e-01	0.22400	0.092500	0.204000	2.89e-01	1.90e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	12	5.67e-01	6.45e-01	0.22400	0.153000	0.164000	3.60e-01	3.26e-01
Metabolism	1758	1.93e-34	5.26e-32	0.22400	0.170000	0.145000	1.72e-32	4.24e-24
Phase 2 - plateau phase	11	5.86e-01	6.62e-01	0.22400	-0.140000	-0.175000	4.23e-01	3.16e-01
CASP8 activity is inhibited	11	1.51e-01	2.33e-01	0.22400	0.098500	-0.201000	5.72e-01	2.49e-01
Dimerization of procaspase-8	11	1.51e-01	2.33e-01	0.22400	0.098500	-0.201000	5.72e-01	2.49e-01
Regulation by c-FLIP	11	1.51e-01	2.33e-01	0.22400	0.098500	-0.201000	5.72e-01	2.49e-01
Termination of translesion DNA synthesis	32	4.09e-03	1.22e-02	0.22300	0.100000	-0.199000	3.26e-01	5.09e-02
Signaling by Rho GTPases	364	1.72e-11	3.61e-10	0.22300	0.080900	0.208000	8.05e-03	9.52e-12
TICAM1-dependent activation of IRF3/IRF7	12	2.29e-01	3.22e-01	0.22300	0.222000	-0.011500	1.82e-01	9.45e-01
Signaling by Nuclear Receptors	214	7.27e-06	4.04e-05	0.22200	0.111000	0.193000	5.17e-03	1.16e-06
Adenylate cyclase inhibitory pathway	11	2.61e-01	3.57e-01	0.22200	-0.011300	0.222000	9.48e-01	2.03e-01
Plasma lipoprotein remodeling	18	2.71e-01	3.68e-01	0.22100	0.070800	0.209000	6.03e-01	1.24e-01
Signaling by FGFR2	60	4.59e-02	9.17e-02	0.22100	0.185000	0.121000	1.33e-02	1.06e-01
TP53 Regulates Transcription of Cell Death Genes	43	2.52e-02	5.68e-02	0.22100	0.216000	0.046200	1.44e-02	6.00e-01
PERK regulates gene expression	31	3.38e-02	7.17e-02	0.22100	0.220000	0.006650	3.36e-02	9.49e-01
Signaling by FGFR3 in disease	13	2.40e-01	3.33e-01	0.22000	0.220000	0.005200	1.70e-01	9.74e-01
Signaling by FGFR3 point mutants in cancer	13	2.40e-01	3.33e-01	0.22000	0.220000	0.005200	1.70e-01	9.74e-01
Mitotic Anaphase	223	2.11e-05	1.08e-04	0.21900	0.178000	0.128000	4.43e-06	1.01e-03
Interferon gamma signaling	83	7.98e-04	2.86e-03	0.21900	-0.043000	-0.215000	4.98e-01	7.15e-04
Pausing and recovery of Tat-mediated HIV elongation	30	1.26e-01	2.00e-01	0.21900	0.074400	0.206000	4.81e-01	5.08e-02
Tat-mediated HIV elongation arrest and recovery	30	1.26e-01	2.00e-01	0.21900	0.074400	0.206000	4.81e-01	5.08e-02
PIP3 activates AKT signaling	239	3.01e-06	1.80e-05	0.21900	0.110000	0.189000	3.42e-03	4.62e-07
MAPK1/MAPK3 signaling	233	3.13e-05	1.54e-04	0.21800	0.148000	0.161000	1.03e-04	2.35e-05
Processive synthesis on the C-strand of the telomere	19	9.57e-02	1.63e-01	0.21800	0.021100	-0.217000	8.73e-01	1.02e-01
Transport of the SLBP independent Mature mRNA	35	3.38e-02	7.17e-02	0.21700	-0.022100	-0.216000	8.21e-01	2.68e-02
Metabolism of proteins	1706	2.40e-31	5.44e-29	0.21600	0.164000	0.141000	1.35e-29	3.77e-22
Mitotic Metaphase and Anaphase	224	2.43e-05	1.21e-04	0.21600	0.177000	0.123000	4.70e-06	1.52e-03
VEGFR2 mediated cell proliferation	18	2.60e-01	3.56e-01	0.21500	0.057000	0.207000	6.75e-01	1.28e-01
APC-Cdc20 mediated degradation of Nek2A	26	7.81e-02	1.39e-01	0.21500	0.214000	0.016100	5.85e-02	8.87e-01
GABA synthesis, release, reuptake and degradation	13	1.17e-01	1.91e-01	0.21500	0.182000	-0.113000	2.55e-01	4.81e-01
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	113	6.37e-08	5.05e-07	0.21400	0.071000	-0.202000	1.93e-01	2.03e-04
Nonsense-Mediated Decay (NMD)	113	6.37e-08	5.05e-07	0.21400	0.071000	-0.202000	1.93e-01	2.03e-04
PKMTs methylate histone lysines	44	9.46e-03	2.58e-02	0.21400	-0.214000	-0.001080	1.41e-02	9.90e-01
Long-term potentiation	14	2.17e-01	3.09e-01	0.21400	0.004190	-0.214000	9.78e-01	1.66e-01
PRC2 methylates histones and DNA	29	9.82e-02	1.66e-01	0.21400	0.045400	0.209000	6.72e-01	5.16e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.77e-01	2.65e-01	0.21400	0.029300	-0.212000	8.49e-01	1.70e-01
Nephrin family interactions	18	2.90e-01	3.88e-01	0.21300	-0.203000	-0.066200	1.36e-01	6.27e-01
p75 NTR receptor-mediated signalling	88	1.23e-02	3.21e-02	0.21300	0.110000	0.183000	7.50e-02	3.01e-03
Activation of HOX genes during differentiation	69	1.05e-04	4.69e-04	0.21300	-0.046300	0.208000	5.06e-01	2.78e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis	69	1.05e-04	4.69e-04	0.21300	-0.046300	0.208000	5.06e-01	2.78e-03
tRNA processing in the nucleus	59	2.35e-03	7.48e-03	0.21300	-0.005320	-0.213000	9.44e-01	4.64e-03
Synthesis of DNA	118	1.63e-06	1.03e-05	0.21300	0.213000	-0.012700	6.56e-05	8.12e-01
Inactivation of APC/C via direct inhibition of the APC/C complex	21	1.47e-01	2.28e-01	0.21300	0.211000	0.023900	9.35e-02	8.50e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	1.47e-01	2.28e-01	0.21300	0.211000	0.023900	9.35e-02	8.50e-01
Downstream signaling of activated FGFR1	20	3.81e-01	4.76e-01	0.21300	0.179000	0.115000	1.65e-01	3.75e-01
G beta:gamma signalling through PI3Kgamma	22	2.23e-01	3.16e-01	0.21300	0.066100	0.202000	5.91e-01	1.01e-01
Repression of WNT target genes	14	5.49e-01	6.29e-01	0.21300	-0.141000	-0.159000	3.61e-01	3.03e-01
HIV elongation arrest and recovery	32	1.08e-01	1.80e-01	0.21200	0.063100	0.203000	5.37e-01	4.71e-02
Pausing and recovery of HIV elongation	32	1.08e-01	1.80e-01	0.21200	0.063100	0.203000	5.37e-01	4.71e-02
Translesion synthesis by POLK	17	1.07e-01	1.78e-01	0.21200	0.045700	-0.207000	7.44e-01	1.39e-01
HCMV Late Events	69	4.91e-02	9.65e-02	0.21200	0.131000	0.166000	5.92e-02	1.70e-02
Maturation of nucleoprotein	10	6.42e-01	7.11e-01	0.21200	-0.128000	-0.168000	4.83e-01	3.56e-01
Regulation of expression of SLITs and ROBOs	158	2.12e-09	2.28e-08	0.21200	0.208000	-0.039300	6.50e-06	3.94e-01
DNA Damage/Telomere Stress Induced Senescence	44	2.82e-02	6.20e-02	0.21100	0.039700	0.208000	6.48e-01	1.72e-02
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	1.33e-02	3.44e-02	0.21000	0.194000	0.080700	4.14e-03	2.33e-01
FRS-mediated FGFR2 signaling	14	2.54e-01	3.47e-01	0.21000	0.210000	0.008100	1.74e-01	9.58e-01
Sema3A PAK dependent Axon repulsion	16	3.74e-01	4.69e-01	0.21000	0.196000	0.075500	1.75e-01	6.01e-01
mRNA Splicing - Minor Pathway	52	7.44e-02	1.33e-01	0.20900	0.183000	0.103000	2.28e-02	2.01e-01
MAPK family signaling cascades	267	1.71e-05	8.96e-05	0.20900	0.139000	0.157000	9.23e-05	1.05e-05
Defective B3GALT6 causes EDSP2 and SEMDJL1	11	5.16e-01	6.03e-01	0.20900	-0.077000	-0.194000	6.58e-01	2.64e-01
PI-3K cascade:FGFR4	10	6.19e-01	6.92e-01	0.20900	0.179000	0.107000	3.28e-01	5.56e-01
Post-translational protein modification	1183	1.18e-21	1.15e-19	0.20800	0.126000	0.166000	2.77e-13	6.39e-22
Transcription of the HIV genome	67	4.93e-02	9.67e-02	0.20800	0.116000	0.173000	1.01e-01	1.46e-02
Cytosolic sulfonation of small molecules	18	2.21e-01	3.14e-01	0.20700	0.028500	0.205000	8.34e-01	1.31e-01
Cellular hexose transport	15	5.42e-01	6.23e-01	0.20700	-0.136000	-0.156000	3.61e-01	2.95e-01
Phase II - Conjugation of compounds	66	7.03e-02	1.29e-01	0.20700	0.150000	0.143000	3.52e-02	4.46e-02
Signaling by FGFR2 in disease	32	1.11e-01	1.84e-01	0.20700	0.199000	0.055700	5.12e-02	5.85e-01
RAS processing	19	4.67e-01	5.58e-01	0.20700	0.148000	0.144000	2.64e-01	2.76e-01
Regulation of actin dynamics for phagocytic cup formation	122	1.16e-07	9.04e-07	0.20700	0.199000	-0.057500	1.52e-04	2.73e-01
Depolymerisation of the Nuclear Lamina	15	5.07e-01	5.96e-01	0.20600	0.112000	0.173000	4.53e-01	2.45e-01
Insulin receptor signalling cascade	39	1.86e-01	2.73e-01	0.20600	0.120000	0.168000	1.96e-01	6.92e-02
Phospholipid metabolism	184	2.33e-04	9.30e-04	0.20600	0.109000	0.175000	1.05e-02	4.35e-05
FLT3 Signaling	242	6.00e-05	2.81e-04	0.20600	0.132000	0.157000	3.90e-04	2.44e-05
DNA Replication	125	4.26e-06	2.48e-05	0.20500	0.205000	-0.002080	7.42e-05	9.68e-01
RAF/MAP kinase cascade	228	1.27e-04	5.41e-04	0.20500	0.137000	0.153000	3.79e-04	7.13e-05
DAP12 interactions	39	2.16e-01	3.08e-01	0.20500	0.141000	0.149000	1.29e-01	1.08e-01
Formation of Incision Complex in GG-NER	43	1.85e-01	2.73e-01	0.20500	0.147000	0.142000	9.56e-02	1.06e-01
Intracellular signaling by second messengers	271	1.90e-06	1.19e-05	0.20400	0.095800	0.181000	6.62e-03	3.13e-07
tRNA modification in the nucleus and cytosol	43	3.08e-03	9.58e-03	0.20400	0.070100	-0.192000	4.27e-01	2.96e-02
Disorders of Developmental Biology	12	3.18e-01	4.15e-01	0.20400	0.002910	0.204000	9.86e-01	2.21e-01
Disorders of Nervous System Development	12	3.18e-01	4.15e-01	0.20400	0.002910	0.204000	9.86e-01	2.21e-01
Loss of function of MECP2 in Rett syndrome	12	3.18e-01	4.15e-01	0.20400	0.002910	0.204000	9.86e-01	2.21e-01
Pervasive developmental disorders	12	3.18e-01	4.15e-01	0.20400	0.002910	0.204000	9.86e-01	2.21e-01
Miscellaneous transport and binding events	20	2.71e-01	3.68e-01	0.20400	0.058400	0.195000	6.51e-01	1.30e-01
Regulation of FOXO transcriptional activity by acetylation	10	2.23e-01	3.16e-01	0.20400	-0.170000	0.113000	3.53e-01	5.37e-01
HDR through Homologous Recombination (HRR)	66	9.87e-03	2.67e-02	0.20300	-0.047800	-0.198000	5.02e-01	5.47e-03
Glucose metabolism	83	3.81e-02	7.94e-02	0.20300	0.155000	0.132000	1.48e-02	3.80e-02
G1/S Transition	130	7.63e-06	4.16e-05	0.20300	0.203000	0.009170	6.42e-05	8.57e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	5.09e-01	5.97e-01	0.20300	-0.076100	-0.188000	6.48e-01	2.59e-01
G2/M Checkpoints	138	3.55e-04	1.38e-03	0.20300	0.189000	0.071600	1.21e-04	1.47e-01
Extracellular matrix organization	215	2.23e-05	1.13e-04	0.20100	0.087500	0.181000	2.70e-02	4.61e-06
Synthesis of substrates in N-glycan biosythesis	58	6.25e-02	1.17e-01	0.20100	0.178000	0.093800	1.90e-02	2.17e-01
NF-kB is activated and signals survival	12	6.02e-01	6.77e-01	0.20100	0.167000	0.111000	3.15e-01	5.06e-01
Meiotic synapsis	45	4.21e-02	8.58e-02	0.20100	0.043100	0.196000	6.17e-01	2.28e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	4.52e-01	5.43e-01	0.20100	0.143000	0.140000	2.55e-01	2.66e-01
Transport of the SLBP Dependant Mature mRNA	36	3.33e-02	7.08e-02	0.20000	0.003040	-0.200000	9.75e-01	3.82e-02
Metabolism of carbohydrates	241	6.81e-05	3.13e-04	0.20000	0.117000	0.162000	1.80e-03	1.49e-05
Signaling by NOTCH3	42	1.07e-01	1.78e-01	0.20000	0.077200	0.184000	3.87e-01	3.91e-02
Negative epigenetic regulation of rRNA expression	62	6.08e-02	1.15e-01	0.19900	0.097900	0.174000	1.83e-01	1.80e-02
Defective B4GALT7 causes EDS, progeroid type	11	5.19e-01	6.05e-01	0.19900	-0.062700	-0.189000	7.19e-01	2.77e-01
Eicosanoid ligand-binding receptors	13	2.77e-01	3.74e-01	0.19900	0.011200	-0.199000	9.44e-01	2.14e-01
NR1H2 and NR1H3-mediated signaling	38	9.32e-03	2.55e-02	0.19900	-0.057800	0.191000	5.38e-01	4.21e-02
HCMV Infection	96	2.17e-02	5.04e-02	0.19900	0.116000	0.162000	4.94e-02	6.20e-03
Metabolism of fat-soluble vitamins	28	1.44e-01	2.26e-01	0.19900	0.042000	0.194000	7.01e-01	7.55e-02
Lysosphingolipid and LPA receptors	11	5.29e-01	6.12e-01	0.19800	-0.064800	-0.188000	7.10e-01	2.82e-01
HSF1 activation	26	8.93e-02	1.54e-01	0.19800	0.198000	-0.002720	8.05e-02	9.81e-01
NOTCH3 Intracellular Domain Regulates Transcription	20	1.06e-01	1.77e-01	0.19800	-0.039500	0.194000	7.60e-01	1.34e-01
Acyl chain remodelling of PE	20	4.81e-01	5.71e-01	0.19700	0.136000	0.143000	2.93e-01	2.68e-01
Anti-inflammatory response favouring Leishmania parasite infection	167	2.24e-09	2.35e-08	0.19700	0.055900	-0.189000	2.13e-01	2.51e-05
Leishmania parasite growth and survival	167	2.24e-09	2.35e-08	0.19700	0.055900	-0.189000	2.13e-01	2.51e-05
Ion channel transport	133	3.91e-03	1.18e-02	0.19600	0.103000	0.167000	3.97e-02	8.72e-04
Interferon Signaling	177	2.10e-05	1.07e-04	0.19600	-0.054700	-0.189000	2.10e-01	1.48e-05
Metabolism of non-coding RNA	53	1.56e-03	5.18e-03	0.19600	0.062000	-0.186000	4.35e-01	1.89e-02
snRNP Assembly	53	1.56e-03	5.18e-03	0.19600	0.062000	-0.186000	4.35e-01	1.89e-02
MicroRNA (miRNA) biogenesis	24	4.11e-01	5.08e-01	0.19600	0.124000	0.152000	2.93e-01	1.99e-01
Diseases associated with N-glycosylation of proteins	17	4.52e-01	5.43e-01	0.19600	0.175000	0.087200	2.11e-01	5.34e-01
Formation of the beta-catenin:TCF transactivating complex	46	1.93e-02	4.60e-02	0.19500	0.004610	0.195000	9.57e-01	2.24e-02
SHC-mediated cascade:FGFR2	12	1.96e-01	2.88e-01	0.19500	0.165000	-0.103000	3.22e-01	5.38e-01
G1/S-Specific Transcription	29	1.78e-02	4.42e-02	0.19400	0.120000	-0.152000	2.62e-01	1.56e-01
Influenza Infection	153	6.30e-09	5.80e-08	0.19400	0.072300	-0.180000	1.23e-01	1.20e-04
Signaling by the B Cell Receptor (BCR)	161	1.28e-08	1.14e-07	0.19400	0.187000	-0.049900	4.15e-05	2.75e-01
Potential therapeutics for SARS	78	4.23e-02	8.60e-02	0.19300	0.101000	0.165000	1.21e-01	1.19e-02
Phase 4 - resting membrane potential	10	5.40e-01	6.23e-01	0.19300	0.187000	0.049200	3.06e-01	7.88e-01
ABC transporters in lipid homeostasis	14	3.57e-01	4.53e-01	0.19300	-0.025000	-0.191000	8.71e-01	2.15e-01
Keratan sulfate/keratin metabolism	25	1.41e-01	2.22e-01	0.19300	0.015900	0.192000	8.91e-01	9.60e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	1.45e-01	2.27e-01	0.19300	-0.018400	0.192000	8.86e-01	1.37e-01
Trafficking of AMPA receptors	20	1.45e-01	2.27e-01	0.19300	-0.018400	0.192000	8.86e-01	1.37e-01
Signaling by TGFB family members	91	1.87e-02	4.51e-02	0.19200	0.089300	0.170000	1.41e-01	4.96e-03
Metabolic disorders of biological oxidation enzymes	23	4.28e-01	5.22e-01	0.19200	0.155000	0.115000	2.00e-01	3.42e-01
RUNX3 regulates p14-ARF	10	3.78e-01	4.73e-01	0.19200	-0.022000	0.190000	9.04e-01	2.97e-01
Retinoid metabolism and transport	24	1.79e-01	2.67e-01	0.19100	0.024800	0.189000	8.33e-01	1.09e-01
Laminin interactions	21	3.53e-01	4.49e-01	0.19000	0.071200	0.177000	5.72e-01	1.61e-01
Fatty acyl-CoA biosynthesis	33	3.18e-01	4.15e-01	0.19000	0.121000	0.146000	2.28e-01	1.46e-01
Signaling by ERBB2	44	1.80e-01	2.68e-01	0.19000	0.099800	0.161000	2.52e-01	6.40e-02
Neurotransmitter receptors and postsynaptic signal transmission	123	6.53e-03	1.85e-02	0.19000	0.092700	0.165000	7.59e-02	1.53e-03
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.98e-01	3.94e-01	0.18900	0.184000	0.045100	1.54e-01	7.27e-01
Transcriptional regulation by RUNX1	184	1.27e-04	5.41e-04	0.18900	0.070400	0.176000	9.97e-02	3.90e-05
RIP-mediated NFkB activation via ZBP1	17	5.45e-01	6.26e-01	0.18900	0.113000	0.152000	4.19e-01	2.79e-01
Defects in vitamin and cofactor metabolism	21	4.26e-01	5.20e-01	0.18900	-0.093600	-0.165000	4.58e-01	1.92e-01
Signaling by TGF-beta Receptor Complex	72	1.34e-02	3.46e-02	0.18900	0.044900	0.183000	5.10e-01	7.17e-03
ZBP1(DAI) mediated induction of type I IFNs	20	4.63e-01	5.54e-01	0.18800	0.098600	0.160000	4.45e-01	2.15e-01
Translesion Synthesis by POLH	18	9.42e-02	1.60e-01	0.18800	0.122000	-0.143000	3.69e-01	2.94e-01
Mitotic G1 phase and G1/S transition	148	4.73e-05	2.26e-04	0.18800	0.186000	0.028400	9.54e-05	5.51e-01
Signaling by WNT in cancer	30	2.09e-02	4.88e-02	0.18800	-0.152000	0.111000	1.51e-01	2.94e-01
Resolution of D-Loop Structures	33	3.38e-01	4.34e-01	0.18700	-0.131000	-0.134000	1.94e-01	1.83e-01
Cell surface interactions at the vascular wall	172	1.95e-08	1.64e-07	0.18700	0.182000	-0.044300	3.98e-05	3.16e-01
Early Phase of HIV Life Cycle	14	1.65e-01	2.51e-01	0.18700	0.147000	-0.116000	3.42e-01	4.54e-01
Nitric oxide stimulates guanylate cyclase	14	5.68e-01	6.45e-01	0.18600	0.088200	0.164000	5.68e-01	2.89e-01
FCGR3A-mediated phagocytosis	120	7.02e-07	4.78e-06	0.18600	0.167000	-0.081300	1.55e-03	1.24e-01
Leishmania phagocytosis	120	7.02e-07	4.78e-06	0.18600	0.167000	-0.081300	1.55e-03	1.24e-01
Parasite infection	120	7.02e-07	4.78e-06	0.18600	0.167000	-0.081300	1.55e-03	1.24e-01
Stimuli-sensing channels	72	9.65e-02	1.64e-01	0.18600	0.126000	0.137000	6.48e-02	4.48e-02
Factors involved in megakaryocyte development and platelet production	116	1.22e-02	3.20e-02	0.18600	0.094800	0.160000	7.78e-02	2.98e-03
Negative regulation of MAPK pathway	42	2.25e-01	3.18e-01	0.18600	0.105000	0.153000	2.40e-01	8.59e-02
Activation of RAC1	11	7.00e-01	7.61e-01	0.18600	0.125000	0.137000	4.72e-01	4.32e-01
Downregulation of ERBB2 signaling	24	3.50e-01	4.45e-01	0.18500	0.077400	0.168000	5.12e-01	1.53e-01
Interleukin-20 family signaling	17	5.12e-01	6.00e-01	0.18500	0.162000	0.090200	2.48e-01	5.19e-01
Removal of the Flap Intermediate from the C-strand	17	1.83e-01	2.71e-01	0.18500	0.039400	-0.181000	7.79e-01	1.96e-01
Mitotic G2-G2/M phases	180	1.05e-03	3.59e-03	0.18500	0.160000	0.092900	2.12e-04	3.16e-02
RET signaling	32	3.16e-01	4.14e-01	0.18500	0.101000	0.155000	3.23e-01	1.30e-01
G2/M Transition	178	9.22e-04	3.24e-03	0.18400	0.162000	0.087600	1.92e-04	4.38e-02
Downstream signal transduction	27	3.10e-01	4.08e-01	0.18400	0.076300	0.167000	4.92e-01	1.32e-01
Antiviral mechanism by IFN-stimulated genes	80	3.14e-02	6.76e-02	0.18400	-0.075600	-0.167000	2.42e-01	9.65e-03
Glycolysis	66	1.02e-01	1.71e-01	0.18300	0.151000	0.104000	3.36e-02	1.45e-01
TCR signaling	121	1.97e-03	6.35e-03	0.18300	0.175000	0.054500	8.85e-04	3.00e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	32	3.48e-01	4.43e-01	0.18300	-0.112000	-0.145000	2.73e-01	1.56e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	19	5.33e-01	6.16e-01	0.18300	-0.110000	-0.146000	4.05e-01	2.71e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	3.26e-01	4.21e-01	0.18200	0.182000	-0.016800	2.57e-01	9.17e-01
Constitutive Signaling by AKT1 E17K in Cancer	26	4.36e-02	8.78e-02	0.18100	-0.109000	0.145000	3.36e-01	2.02e-01
Potassium Channels	63	1.40e-01	2.20e-01	0.18100	0.137000	0.118000	5.91e-02	1.06e-01
Metabolism of amino acids and derivatives	323	1.32e-11	2.82e-10	0.18100	0.181000	-0.004500	2.29e-08	8.89e-01
Regulation of TP53 Activity through Methylation	19	5.41e-01	6.23e-01	0.18100	-0.109000	-0.144000	4.11e-01	2.77e-01
Axon guidance	451	6.55e-07	4.53e-06	0.18000	0.144000	0.109000	1.68e-07	7.16e-05
Late Phase of HIV Life Cycle	131	1.85e-02	4.51e-02	0.18000	0.134000	0.120000	8.17e-03	1.75e-02
BBSome-mediated cargo-targeting to cilium	22	7.24e-02	1.31e-01	0.18000	0.115000	-0.138000	3.51e-01	2.63e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	5.95e-01	6.71e-01	0.17900	0.094000	0.152000	5.28e-01	3.09e-01
Tight junction interactions	18	1.22e-01	1.97e-01	0.17800	0.107000	-0.143000	4.31e-01	2.94e-01
TP53 Regulates Transcription of Death Receptors and Ligands	12	2.96e-01	3.93e-01	0.17800	0.168000	-0.058100	3.12e-01	7.28e-01
E2F mediated regulation of DNA replication	22	7.51e-02	1.34e-01	0.17800	0.119000	-0.132000	3.34e-01	2.83e-01
Xenobiotics	11	5.47e-01	6.27e-01	0.17800	0.174000	0.039100	3.19e-01	8.22e-01
FGFR2 mutant receptor activation	22	2.89e-01	3.87e-01	0.17700	0.174000	0.034500	1.59e-01	7.79e-01
Processing of Capped Intronless Pre-mRNA	28	3.45e-01	4.40e-01	0.17700	0.158000	0.079200	1.47e-01	4.68e-01
Assembly and cell surface presentation of NMDA receptors	18	1.71e-01	2.57e-01	0.17700	0.054400	-0.168000	6.90e-01	2.17e-01
Transport of vitamins, nucleosides, and related molecules	32	1.76e-01	2.65e-01	0.17600	0.038200	0.172000	7.09e-01	9.17e-02
Cargo trafficking to the periciliary membrane	47	2.04e-01	2.96e-01	0.17600	0.150000	0.092400	7.47e-02	2.73e-01
Apoptotic cleavage of cellular proteins	34	2.76e-01	3.74e-01	0.17600	0.078700	0.158000	4.27e-01	1.11e-01
Infectious disease	773	8.59e-13	2.25e-11	0.17500	0.156000	0.078700	1.33e-13	1.97e-04
CLEC7A (Dectin-1) induces NFAT activation	11	3.26e-01	4.21e-01	0.17500	-0.162000	0.067100	3.53e-01	7.00e-01
Nuclear Pore Complex (NPC) Disassembly	36	9.50e-02	1.61e-01	0.17500	-0.012400	-0.175000	8.97e-01	6.97e-02
PI-3K cascade:FGFR1	12	6.92e-01	7.57e-01	0.17500	0.103000	0.141000	5.38e-01	3.97e-01
Recognition of DNA damage by PCNA-containing replication complex	30	4.35e-02	8.77e-02	0.17500	0.076500	-0.157000	4.68e-01	1.37e-01
Glutamate Neurotransmitter Release Cycle	20	1.16e-01	1.89e-01	0.17300	0.092500	-0.147000	4.74e-01	2.56e-01
FOXO-mediated transcription of cell death genes	16	3.61e-01	4.56e-01	0.17300	0.013300	0.173000	9.26e-01	2.31e-01
ATF4 activates genes in response to endoplasmic reticulum stress	26	8.51e-02	1.48e-01	0.17300	0.164000	-0.054900	1.48e-01	6.28e-01
Degradation of cysteine and homocysteine	12	7.08e-01	7.67e-01	0.17300	0.109000	0.134000	5.12e-01	4.23e-01
MECP2 regulates neuronal receptors and channels	13	2.67e-01	3.64e-01	0.17300	-0.073900	0.156000	6.45e-01	3.30e-01
Nuclear Receptor transcription pathway	37	1.39e-01	2.20e-01	0.17200	-0.169000	-0.033900	7.53e-02	7.21e-01
Glycosaminoglycan metabolism	92	6.76e-03	1.91e-02	0.17200	0.030100	0.169000	6.18e-01	5.10e-03
Signaling by FGFR	69	1.50e-01	2.33e-01	0.17100	0.126000	0.116000	7.13e-02	9.57e-02
Olfactory Signaling Pathway	55	1.12e-01	1.85e-01	0.17100	0.159000	0.063700	4.20e-02	4.14e-01
Interleukin-37 signaling	19	1.30e-01	2.07e-01	0.17100	-0.105000	0.135000	4.29e-01	3.09e-01
SUMOylation of SUMOylation proteins	35	1.88e-01	2.75e-01	0.17000	-0.043300	-0.165000	6.58e-01	9.14e-02
mRNA Splicing	187	2.22e-03	7.12e-03	0.17000	0.148000	0.084100	4.77e-04	4.75e-02
Nervous system development	470	2.58e-06	1.57e-05	0.16900	0.133000	0.105000	8.19e-07	9.50e-05
NOTCH4 Intracellular Domain Regulates Transcription	17	2.45e-01	3.39e-01	0.16900	-0.165000	0.035700	2.40e-01	7.99e-01
Activation of kainate receptors upon glutamate binding	25	4.89e-01	5.78e-01	0.16800	0.097900	0.137000	3.97e-01	2.37e-01
Transcriptional Regulation by E2F6	34	2.37e-01	3.31e-01	0.16800	-0.052700	-0.160000	5.95e-01	1.07e-01
Phase I - Functionalization of compounds	61	1.46e-01	2.28e-01	0.16800	0.145000	0.083900	4.99e-02	2.57e-01
Neurexins and neuroligins	35	3.81e-01	4.76e-01	0.16700	-0.102000	-0.133000	2.97e-01	1.74e-01
Circadian Clock	67	1.87e-02	4.51e-02	0.16700	0.012300	0.167000	8.62e-01	1.82e-02
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	1.61e-02	4.06e-02	0.16700	-0.056500	0.157000	5.07e-01	6.49e-02
HIV Life Cycle	144	1.76e-02	4.38e-02	0.16700	0.136000	0.097200	4.92e-03	4.41e-02
CaM pathway	27	4.16e-01	5.11e-01	0.16600	0.078500	0.147000	4.80e-01	1.87e-01
Calmodulin induced events	27	4.16e-01	5.11e-01	0.16600	0.078500	0.147000	4.80e-01	1.87e-01
TRAF3-dependent IRF activation pathway	13	6.41e-01	7.11e-01	0.16600	0.150000	0.072600	3.50e-01	6.51e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	3.34e-01	4.30e-01	0.16600	0.030400	-0.163000	8.44e-01	2.90e-01
Keratinization	33	2.63e-01	3.59e-01	0.16600	0.157000	0.054600	1.19e-01	5.87e-01
Polo-like kinase mediated events	15	6.66e-01	7.34e-01	0.16600	0.101000	0.132000	4.98e-01	3.78e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	12	2.95e-01	3.92e-01	0.16500	0.111000	-0.122000	5.04e-01	4.64e-01
mRNA Splicing - Major Pathway	179	3.91e-03	1.18e-02	0.16500	0.144000	0.080900	8.79e-04	6.20e-02
Mitotic Prophase	98	8.23e-02	1.45e-01	0.16500	0.116000	0.118000	4.77e-02	4.39e-02
Signaling by PDGF	44	2.25e-01	3.18e-01	0.16500	0.071100	0.149000	4.14e-01	8.75e-02
Synthesis of IP2, IP, and Ins in the cytosol	13	7.14e-01	7.72e-01	0.16500	0.125000	0.107000	4.35e-01	5.03e-01
Signaling by Activin	10	5.21e-01	6.06e-01	0.16500	0.004660	-0.164000	9.80e-01	3.68e-01
Rho GTPase cycle	125	3.76e-04	1.45e-03	0.16400	-0.000755	0.164000	9.88e-01	1.50e-03
Establishment of Sister Chromatid Cohesion	11	7.52e-01	8.02e-01	0.16400	0.126000	0.106000	4.70e-01	5.44e-01
Transport of Mature mRNA Derived from an Intronless Transcript	42	1.49e-01	2.31e-01	0.16300	-0.038100	-0.159000	6.69e-01	7.48e-02
Mitochondrial tRNA aminoacylation	21	4.85e-01	5.74e-01	0.16300	-0.066600	-0.149000	5.97e-01	2.37e-01
Defective B3GAT3 causes JDSSDHD	11	6.35e-01	7.07e-01	0.16300	-0.047900	-0.156000	7.83e-01	3.71e-01
Fcgamma receptor (FCGR) dependent phagocytosis	146	1.93e-05	9.94e-05	0.16200	0.160000	-0.029700	8.62e-04	5.36e-01
Collagen formation	64	3.21e-02	6.89e-02	0.16200	0.016400	0.161000	8.21e-01	2.58e-02
Antigen processing: Ubiquitination & Proteasome degradation	286	7.83e-04	2.82e-03	0.16200	0.102000	0.126000	2.98e-03	2.60e-04
Biological oxidations	132	2.60e-02	5.78e-02	0.16200	0.136000	0.087600	6.98e-03	8.21e-02
Regulation of MECP2 expression and activity	28	7.55e-02	1.35e-01	0.16100	-0.081900	0.139000	4.53e-01	2.03e-01
PKA-mediated phosphorylation of CREB	17	2.96e-01	3.93e-01	0.16100	-0.025200	0.159000	8.57e-01	2.56e-01
DNA Double Strand Break Response	47	1.83e-02	4.50e-02	0.16100	-0.059400	0.150000	4.81e-01	7.58e-02
Glutamate and glutamine metabolism	12	3.21e-01	4.16e-01	0.16100	0.129000	-0.095400	4.37e-01	5.67e-01
Collagen chain trimerization	27	1.23e-01	1.98e-01	0.16000	-0.155000	0.041000	1.63e-01	7.13e-01
Disease	1339	2.57e-14	8.76e-13	0.16000	0.125000	0.101000	1.99e-14	6.27e-10
M Phase	359	1.68e-04	6.97e-04	0.16000	0.123000	0.103000	6.58e-05	7.98e-04
tRNA processing	136	4.70e-03	1.39e-02	0.16000	-0.046700	-0.153000	3.47e-01	2.09e-03
Transmission across Chemical Synapses	170	1.69e-02	4.23e-02	0.16000	0.105000	0.120000	1.79e-02	6.97e-03
Mismatch Repair	15	2.89e-01	3.86e-01	0.15900	0.057700	-0.148000	6.99e-01	3.20e-01
Signaling by ROBO receptors	198	7.49e-06	4.11e-05	0.15900	0.159000	-0.002830	1.17e-04	9.45e-01
Carboxyterminal post-translational modifications of tubulin	26	4.56e-01	5.46e-01	0.15900	0.072300	0.141000	5.23e-01	2.13e-01
Intraflagellar transport	39	3.61e-01	4.56e-01	0.15900	-0.131000	-0.088800	1.56e-01	3.37e-01
Attenuation phase	23	5.41e-01	6.23e-01	0.15800	0.133000	0.084900	2.68e-01	4.81e-01
Amino acid transport across the plasma membrane	23	5.00e-01	5.88e-01	0.15800	0.141000	0.070800	2.42e-01	5.57e-01
Transcriptional activation of mitochondrial biogenesis	51	2.22e-01	3.16e-01	0.15700	0.072000	0.140000	3.74e-01	8.46e-02
Downstream signaling of activated FGFR2	19	3.70e-01	4.65e-01	0.15700	0.157000	0.011700	2.37e-01	9.29e-01
WNT ligand biogenesis and trafficking	21	5.20e-01	6.06e-01	0.15600	0.065600	0.142000	6.03e-01	2.60e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.84e-01	5.73e-01	0.15600	0.027200	0.154000	8.51e-01	2.86e-01
CTLA4 inhibitory signaling	21	3.84e-01	4.78e-01	0.15600	-0.154000	-0.026500	2.22e-01	8.34e-01
Death Receptor Signalling	131	5.02e-02	9.80e-02	0.15600	0.113000	0.107000	2.50e-02	3.36e-02
Dopamine Neurotransmitter Release Cycle	19	4.98e-01	5.87e-01	0.15600	-0.048600	-0.148000	7.14e-01	2.63e-01
Ion transport by P-type ATPases	43	3.41e-02	7.20e-02	0.15600	-0.146000	0.054700	9.83e-02	5.35e-01
Cytochrome P450 - arranged by substrate type	32	3.83e-01	4.77e-01	0.15600	0.140000	0.067600	1.70e-01	5.08e-01
Signal Transduction	1869	7.70e-23	9.58e-21	0.15600	0.068400	0.140000	9.87e-07	1.51e-23
TP53 Regulates Transcription of Cell Cycle Genes	47	4.86e-02	9.61e-02	0.15500	0.154000	-0.018800	6.73e-02	8.23e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	3.36e-02	7.15e-02	0.15500	0.119000	-0.099700	2.04e-01	2.88e-01
RUNX2 regulates osteoblast differentiation	17	4.25e-01	5.20e-01	0.15500	-0.154000	-0.013200	2.71e-01	9.25e-01
Nuclear Envelope (NE) Reassembly	69	2.12e-01	3.04e-01	0.15400	0.117000	0.099200	9.24e-02	1.54e-01
Deadenylation-dependent mRNA decay	53	1.17e-01	1.91e-01	0.15300	0.150000	0.034600	5.97e-02	6.63e-01
SUMOylation of transcription cofactors	44	2.14e-02	4.97e-02	0.15300	-0.115000	0.102000	1.87e-01	2.43e-01
Synthesis of PIPs at the plasma membrane	52	3.25e-02	6.95e-02	0.15300	-0.026900	0.151000	7.38e-01	5.99e-02
Mitochondrial Fatty Acid Beta-Oxidation	36	4.34e-01	5.28e-01	0.15300	0.122000	0.091800	2.04e-01	3.41e-01
Developmental Biology	726	1.49e-07	1.14e-06	0.15100	0.093700	0.119000	1.73e-05	4.86e-08
tRNA Aminoacylation	42	3.03e-02	6.59e-02	0.15100	0.124000	-0.086900	1.65e-01	3.30e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	6.94e-01	7.58e-01	0.15100	-0.041300	-0.145000	8.21e-01	4.26e-01
Defective EXT2 causes exostoses 2	10	6.94e-01	7.58e-01	0.15100	-0.041300	-0.145000	8.21e-01	4.26e-01
Nonhomologous End-Joining (NHEJ)	42	2.22e-01	3.15e-01	0.15100	0.042500	0.145000	6.33e-01	1.05e-01
Association of TriC/CCT with target proteins during biosynthesis	37	4.54e-01	5.45e-01	0.15100	0.110000	0.103000	2.49e-01	2.76e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	5.51e-01	6.31e-01	0.15000	-0.111000	-0.101000	3.08e-01	3.56e-01
IRF3-mediated induction of type I IFN	12	4.33e-01	5.27e-01	0.15000	0.144000	-0.042800	3.88e-01	7.97e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14	3.35e-01	4.30e-01	0.15000	0.133000	-0.069200	3.88e-01	6.54e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	5.41e-01	6.23e-01	0.15000	-0.122000	-0.087400	2.73e-01	4.32e-01
Regulation of localization of FOXO transcription factors	12	3.67e-01	4.62e-01	0.15000	-0.101000	0.111000	5.45e-01	5.06e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	6.84e-01	7.50e-01	0.14900	0.145000	0.034300	4.27e-01	8.51e-01
S Phase	160	2.05e-04	8.36e-04	0.14900	0.149000	-0.003830	1.14e-03	9.33e-01
Receptor-type tyrosine-protein phosphatases	11	6.89e-01	7.55e-01	0.14900	-0.142000	-0.045200	4.15e-01	7.95e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	4.23e-01	5.19e-01	0.14900	0.149000	0.002520	2.88e-01	9.86e-01
RAF-independent MAPK1/3 activation	21	5.77e-01	6.55e-01	0.14800	0.131000	0.068300	2.97e-01	5.88e-01
Muscle contraction	135	2.43e-02	5.52e-02	0.14800	0.062700	0.134000	2.09e-01	7.11e-03
Collagen biosynthesis and modifying enzymes	46	4.24e-02	8.60e-02	0.14800	-0.045600	0.141000	5.92e-01	9.90e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	43	1.53e-01	2.35e-01	0.14700	-0.016700	-0.146000	8.50e-01	9.69e-02
Regulation of TNFR1 signaling	34	1.80e-01	2.68e-01	0.14600	0.002050	-0.146000	9.83e-01	1.41e-01
RNA Polymerase I Promoter Clearance	63	1.99e-01	2.91e-01	0.14600	0.065800	0.130000	3.66e-01	7.43e-02
RNA Polymerase I Transcription	63	1.99e-01	2.91e-01	0.14600	0.065800	0.130000	3.66e-01	7.43e-02
Meiotic recombination	38	3.71e-01	4.65e-01	0.14400	0.061600	0.130000	5.11e-01	1.64e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	5.26e-01	6.10e-01	0.14400	-0.002710	0.144000	9.87e-01	3.69e-01
Cytokine Signaling in Immune system	733	1.39e-07	1.07e-06	0.14400	0.122000	0.076400	1.95e-08	4.32e-04
ECM proteoglycans	34	1.84e-01	2.73e-01	0.14300	-0.004800	0.143000	9.61e-01	1.48e-01
Processing of Intronless Pre-mRNAs	19	6.95e-01	7.58e-01	0.14300	0.100000	0.102000	4.50e-01	4.42e-01
Transcriptional regulation of pluripotent stem cells	20	2.33e-01	3.26e-01	0.14300	-0.075300	0.121000	5.60e-01	3.48e-01
RNA Polymerase II Transcription Termination	65	1.43e-01	2.25e-01	0.14200	0.134000	0.045400	6.08e-02	5.27e-01
Methylation	12	6.13e-01	6.85e-01	0.14200	0.141000	0.015600	3.98e-01	9.25e-01
Leishmania infection	243	2.10e-05	1.07e-04	0.14100	0.141000	0.003820	1.56e-04	9.18e-01
Transcriptional Regulation by MECP2	47	7.44e-02	1.33e-01	0.14100	-0.023700	0.139000	7.78e-01	9.99e-02
Molecules associated with elastic fibres	21	5.43e-01	6.25e-01	0.14100	0.046100	0.133000	7.15e-01	2.92e-01
CD28 co-stimulation	33	3.91e-01	4.86e-01	0.14000	-0.132000	-0.046800	1.90e-01	6.42e-01
Regulation of KIT signaling	15	6.30e-01	7.02e-01	0.14000	0.039500	0.134000	7.91e-01	3.69e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	19	2.62e-01	3.58e-01	0.14000	0.116000	-0.077800	3.82e-01	5.57e-01
SUMOylation of RNA binding proteins	47	1.81e-01	2.69e-01	0.13900	-0.022500	-0.137000	7.90e-01	1.04e-01
Nicotinamide salvaging	14	3.95e-01	4.90e-01	0.13900	0.061700	-0.124000	6.89e-01	4.20e-01
Post-translational modification: synthesis of GPI-anchored proteins	56	2.41e-01	3.34e-01	0.13900	0.128000	0.054800	9.86e-02	4.78e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	7.42e-01	7.94e-01	0.13800	-0.119000	-0.070000	4.39e-01	6.50e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	7.42e-01	7.94e-01	0.13800	-0.119000	-0.070000	4.39e-01	6.50e-01
Acyl chain remodelling of PS	14	7.74e-01	8.21e-01	0.13800	0.089700	0.105000	5.61e-01	4.95e-01
Chromatin modifying enzymes	217	2.26e-07	1.67e-06	0.13800	-0.097700	0.097800	1.32e-02	1.31e-02
Chromatin organization	217	2.26e-07	1.67e-06	0.13800	-0.097700	0.097800	1.32e-02	1.31e-02
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	6.90e-01	7.56e-01	0.13800	0.049800	0.129000	7.47e-01	4.05e-01
ISG15 antiviral mechanism	72	1.09e-01	1.81e-01	0.13800	-0.036400	-0.133000	5.93e-01	5.10e-02
Synthesis of IP3 and IP4 in the cytosol	22	2.31e-01	3.24e-01	0.13700	-0.068900	0.119000	5.76e-01	3.35e-01
Defects in cobalamin (B12) metabolism	13	4.17e-01	5.12e-01	0.13700	0.072900	-0.116000	6.49e-01	4.69e-01
DNA Damage Bypass	47	4.21e-02	8.59e-02	0.13700	0.115000	-0.074600	1.74e-01	3.76e-01
Signaling by NODAL	13	7.85e-01	8.29e-01	0.13600	-0.110000	-0.080500	4.92e-01	6.15e-01
O-linked glycosylation of mucins	46	4.49e-01	5.41e-01	0.13600	0.092600	0.099600	2.77e-01	2.43e-01
Positive epigenetic regulation of rRNA expression	59	3.10e-01	4.08e-01	0.13600	0.072200	0.115000	3.37e-01	1.26e-01
Synthesis of PIPs at the early endosome membrane	16	3.64e-01	4.59e-01	0.13600	-0.059100	0.122000	6.83e-01	3.97e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	79	7.10e-02	1.30e-01	0.13500	0.024700	0.133000	7.04e-01	4.08e-02
Fertilization	12	7.06e-01	7.66e-01	0.13500	0.130000	0.036900	4.37e-01	8.25e-01
RUNX3 regulates NOTCH signaling	14	4.73e-01	5.63e-01	0.13400	-0.031700	0.130000	8.37e-01	3.98e-01
TRAF6 mediated IRF7 activation	15	7.75e-01	8.21e-01	0.13400	0.099400	0.090000	5.05e-01	5.46e-01
Negative regulators of DDX58/IFIH1 signaling	34	1.70e-01	2.56e-01	0.13400	0.131000	-0.028200	1.86e-01	7.76e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	2.39e-01	3.33e-01	0.13400	-0.109000	0.077500	3.77e-01	5.29e-01
Keratan sulfate biosynthesis	20	2.86e-01	3.84e-01	0.13300	-0.116000	0.065600	3.69e-01	6.12e-01
Downregulation of TGF-beta receptor signaling	26	4.68e-01	5.60e-01	0.13300	0.034000	0.129000	7.64e-01	2.56e-01
Activation of NMDA receptors and postsynaptic events	58	3.58e-01	4.53e-01	0.13200	0.076600	0.108000	3.13e-01	1.56e-01
Synthesis of PIPs at the Golgi membrane	16	6.12e-01	6.85e-01	0.13200	0.028000	0.129000	8.46e-01	3.71e-01
PI Metabolism	79	1.85e-02	4.51e-02	0.13200	-0.028000	0.129000	6.67e-01	4.76e-02
Basigin interactions	22	6.93e-01	7.58e-01	0.13100	0.083000	0.102000	5.00e-01	4.09e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	17	5.15e-01	6.03e-01	0.13100	-0.002820	-0.131000	9.84e-01	3.50e-01
Signaling by NTRK3 (TRKC)	15	6.81e-01	7.47e-01	0.13000	0.124000	0.040300	4.07e-01	7.87e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	6.05e-01	6.80e-01	0.13000	0.115000	0.059600	3.19e-01	6.06e-01
Ca2+ pathway	57	3.10e-01	4.08e-01	0.12900	0.056900	0.116000	4.57e-01	1.29e-01
G alpha (12/13) signalling events	68	8.27e-02	1.45e-01	0.12800	0.003830	0.128000	9.56e-01	6.84e-02
Caspase-mediated cleavage of cytoskeletal proteins	12	7.53e-01	8.02e-01	0.12700	0.042200	0.120000	8.00e-01	4.71e-01
Processing of Capped Intron-Containing Pre-mRNA	238	2.56e-03	8.10e-03	0.12700	0.122000	0.035600	1.24e-03	3.44e-01
Assembly of collagen fibrils and other multimeric structures	42	1.68e-01	2.54e-01	0.12700	-0.014800	0.126000	8.69e-01	1.59e-01
Lysine catabolism	11	5.64e-01	6.42e-01	0.12600	-0.118000	0.045600	4.99e-01	7.93e-01
IL-6-type cytokine receptor ligand interactions	12	4.98e-01	5.87e-01	0.12600	0.102000	-0.074200	5.42e-01	6.56e-01
Metabolism of RNA	686	1.94e-14	6.96e-13	0.12600	0.122000	-0.030900	5.16e-08	1.67e-01
Post NMDA receptor activation events	48	4.13e-01	5.10e-01	0.12600	0.059800	0.111000	4.73e-01	1.85e-01
RNA Polymerase I Transcription Termination	27	4.17e-01	5.12e-01	0.12500	0.124000	0.011700	2.63e-01	9.16e-01
SUMOylation of ubiquitinylation proteins	39	3.44e-01	4.40e-01	0.12500	-0.026400	-0.122000	7.76e-01	1.87e-01
Ephrin signaling	17	7.51e-01	8.02e-01	0.12500	0.066100	0.106000	6.37e-01	4.50e-01
HS-GAG biosynthesis	20	6.24e-01	6.95e-01	0.12400	0.036700	0.118000	7.76e-01	3.60e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	3.86e-01	4.80e-01	0.12300	0.081800	-0.091500	5.59e-01	5.14e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23	2.82e-01	3.80e-01	0.12300	-0.072100	0.099200	5.50e-01	4.10e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	20	6.95e-01	7.58e-01	0.12200	0.109000	0.053900	3.98e-01	6.76e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	5.83e-01	6.59e-01	0.12100	-0.121000	-0.007780	3.87e-01	9.56e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	5.83e-01	6.59e-01	0.12100	-0.121000	-0.007780	3.87e-01	9.56e-01
Cell Cycle Checkpoints	258	3.20e-03	9.92e-03	0.12100	0.116000	0.036800	1.37e-03	3.09e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	4.74e-01	5.64e-01	0.12100	0.029500	-0.118000	8.33e-01	4.01e-01
mRNA 3’-end processing	56	3.42e-01	4.38e-01	0.12100	0.111000	0.047600	1.52e-01	5.38e-01
Cyclin D associated events in G1	47	5.24e-01	6.08e-01	0.12000	0.091500	0.077800	2.78e-01	3.56e-01
G1 Phase	47	5.24e-01	6.08e-01	0.12000	0.091500	0.077800	2.78e-01	3.56e-01
TNFR1-induced NFkappaB signaling pathway	25	2.71e-01	3.68e-01	0.12000	0.070200	-0.096800	5.43e-01	4.02e-01
RMTs methylate histone arginines	37	1.47e-01	2.28e-01	0.11900	-0.097700	0.068600	3.04e-01	4.70e-01
Inositol phosphate metabolism	42	2.13e-01	3.05e-01	0.11900	-0.011100	0.119000	9.01e-01	1.83e-01
Termination of O-glycan biosynthesis	16	4.84e-01	5.73e-01	0.11800	-0.111000	0.040900	4.42e-01	7.77e-01
Interleukin-2 family signaling	38	5.64e-01	6.42e-01	0.11800	0.100000	0.061500	2.84e-01	5.12e-01
PECAM1 interactions	12	5.90e-01	6.67e-01	0.11700	-0.110000	0.039900	5.11e-01	8.11e-01
Interleukin receptor SHC signaling	23	7.39e-01	7.94e-01	0.11600	0.090500	0.073300	4.53e-01	5.43e-01
Regulation of innate immune responses to cytosolic DNA	14	5.06e-01	5.94e-01	0.11600	0.062800	-0.098000	6.84e-01	5.26e-01
Protein-protein interactions at synapses	55	4.76e-01	5.65e-01	0.11600	-0.093700	-0.068800	2.29e-01	3.78e-01
Norepinephrine Neurotransmitter Release Cycle	14	7.25e-01	7.82e-01	0.11600	-0.026800	-0.113000	8.62e-01	4.64e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	7.29e-01	7.86e-01	0.11600	0.091600	0.070700	4.37e-01	5.49e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	8.79e-01	9.08e-01	0.11500	0.071300	0.090300	6.96e-01	6.21e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	10	6.23e-01	6.95e-01	0.11500	0.096800	-0.061400	5.96e-01	7.37e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	7.11e-02	1.30e-01	0.11400	0.020000	-0.113000	7.69e-01	9.84e-02
NCAM signaling for neurite out-growth	43	4.51e-01	5.43e-01	0.11400	-0.039900	-0.107000	6.51e-01	2.24e-01
Cell death signalling via NRAGE, NRIF and NADE	69	2.32e-01	3.25e-01	0.11400	0.029900	0.110000	6.68e-01	1.13e-01
Transcriptional regulation by small RNAs	63	4.02e-01	4.98e-01	0.11300	0.056800	0.098300	4.36e-01	1.77e-01
Neuronal System	253	3.56e-02	7.47e-02	0.11300	0.062500	0.094000	8.68e-02	1.01e-02
SUMOylation of DNA damage response and repair proteins	77	3.44e-01	4.40e-01	0.11300	-0.058500	-0.096200	3.75e-01	1.44e-01
Regulation of TP53 Activity	152	1.51e-01	2.33e-01	0.11300	-0.089600	-0.068100	5.67e-02	1.47e-01
Other semaphorin interactions	16	6.36e-01	7.07e-01	0.11200	0.002910	0.112000	9.84e-01	4.39e-01
SUMOylation of chromatin organization proteins	57	3.06e-01	4.03e-01	0.11200	-0.027700	-0.108000	7.18e-01	1.57e-01
Regulation of beta-cell development	19	4.70e-01	5.61e-01	0.11200	-0.106000	0.036300	4.26e-01	7.84e-01
mRNA decay by 5’ to 3’ exoribonuclease	15	7.55e-01	8.04e-01	0.11100	0.106000	0.034600	4.77e-01	8.17e-01
Adherens junctions interactions	18	5.26e-01	6.10e-01	0.11100	-0.109000	0.023100	4.25e-01	8.65e-01
Bile acid and bile salt metabolism	28	4.38e-01	5.30e-01	0.11100	-0.002730	0.111000	9.80e-01	3.10e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	63	4.25e-01	5.20e-01	0.11100	0.095300	0.056500	1.91e-01	4.38e-01
Ion homeostasis	41	2.06e-01	2.99e-01	0.11000	-0.104000	0.035300	2.48e-01	6.95e-01
Ras activation upon Ca2+ influx through NMDA receptor	15	5.44e-01	6.25e-01	0.11000	0.044900	-0.100000	7.63e-01	5.02e-01
Synaptic adhesion-like molecules	15	5.93e-01	6.69e-01	0.10900	-0.106000	0.024100	4.76e-01	8.71e-01
NOTCH2 intracellular domain regulates transcription	11	7.15e-01	7.73e-01	0.10900	-0.009380	0.108000	9.57e-01	5.34e-01
SUMOylation of DNA replication proteins	46	2.97e-01	3.94e-01	0.10900	-0.003620	-0.109000	9.66e-01	2.03e-01
Dual incision in TC-NER	65	4.39e-01	5.30e-01	0.10800	0.092100	0.056000	1.99e-01	4.35e-01
Blood group systems biosynthesis	17	8.13e-01	8.51e-01	0.10700	0.089900	0.058200	5.21e-01	6.78e-01
DAG and IP3 signaling	33	4.14e-01	5.10e-01	0.10700	-0.000912	0.107000	9.93e-01	2.89e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	8.08e-01	8.47e-01	0.10700	-0.098300	-0.041200	5.24e-01	7.90e-01
IGF1R signaling cascade	36	6.56e-01	7.25e-01	0.10700	0.060100	0.087900	5.32e-01	3.61e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	7.41e-01	7.94e-01	0.10500	0.049800	0.092900	6.79e-01	4.40e-01
MET activates PTK2 signaling	15	7.19e-01	7.76e-01	0.10500	0.012100	0.104000	9.36e-01	4.86e-01
Transcription of E2F targets under negative control by DREAM complex	19	5.79e-01	6.56e-01	0.10400	0.104000	-0.011600	4.34e-01	9.30e-01
O-linked glycosylation	81	4.38e-01	5.30e-01	0.10400	-0.078500	-0.067600	2.22e-01	2.93e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	43	2.14e-01	3.06e-01	0.10300	-0.041300	0.094900	6.39e-01	2.82e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	4.39e-01	5.30e-01	0.10300	0.082500	0.062200	2.08e-01	3.43e-01
Neurotransmitter release cycle	38	2.93e-01	3.90e-01	0.10300	0.099700	-0.026900	2.88e-01	7.74e-01
RNA Polymerase I Transcription Initiation	44	6.34e-01	7.06e-01	0.10200	-0.062100	-0.081400	4.76e-01	3.50e-01
Synthesis of bile acids and bile salts	24	6.72e-01	7.39e-01	0.10200	0.028600	0.098200	8.08e-01	4.05e-01
Negative regulation of the PI3K/AKT network	86	8.59e-02	1.49e-01	0.10200	-0.015100	0.101000	8.09e-01	1.05e-01
HATs acetylate histones	93	6.04e-02	1.15e-01	0.10200	-0.099400	0.022100	9.77e-02	7.13e-01
SLC-mediated transmembrane transport	178	1.18e-01	1.92e-01	0.10200	0.048100	0.089600	2.68e-01	3.93e-02
Sulfur amino acid metabolism	22	8.05e-01	8.45e-01	0.10200	0.076800	0.066600	5.33e-01	5.88e-01
RUNX2 regulates bone development	22	4.35e-01	5.28e-01	0.10100	-0.080000	0.062300	5.16e-01	6.13e-01
Cell junction organization	59	5.56e-01	6.35e-01	0.09980	0.059100	0.080400	4.33e-01	2.85e-01
SUMOylation of DNA methylation proteins	16	7.38e-01	7.93e-01	0.09900	-0.098000	-0.014300	4.97e-01	9.21e-01
RNA Polymerase III Transcription Termination	23	7.37e-01	7.92e-01	0.09840	0.091400	0.036400	4.48e-01	7.62e-01
G0 and Early G1	27	4.40e-01	5.31e-01	0.09840	0.093700	-0.030100	3.99e-01	7.87e-01
Translation of structural proteins	28	4.37e-01	5.30e-01	0.09790	-0.027600	0.093900	8.01e-01	3.90e-01
Signaling by Retinoic Acid	31	7.00e-01	7.61e-01	0.09780	0.087100	0.044300	4.01e-01	6.69e-01
Nucleotide Excision Repair	110	3.76e-01	4.71e-01	0.09700	0.064100	0.072800	2.46e-01	1.87e-01
Interaction between L1 and Ankyrins	20	7.56e-01	8.04e-01	0.09690	-0.091800	-0.031100	4.77e-01	8.10e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	8.32e-01	8.67e-01	0.09680	0.024800	0.093500	8.82e-01	5.75e-01
Non-integrin membrane-ECM interactions	37	5.18e-01	6.05e-01	0.09620	0.014300	0.095100	8.80e-01	3.17e-01
Cell-Cell communication	88	3.70e-01	4.65e-01	0.09500	0.040600	0.085900	5.11e-01	1.64e-01
Transcriptional Regulation by TP53	351	4.86e-02	9.61e-02	0.09480	0.074200	0.059000	1.70e-02	5.76e-02
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	6.38e-01	7.08e-01	0.09400	0.053900	-0.077000	7.27e-01	6.18e-01
Regulation of FZD by ubiquitination	15	8.33e-01	8.68e-01	0.09360	-0.033800	-0.087300	8.20e-01	5.58e-01
DCC mediated attractive signaling	13	7.88e-01	8.31e-01	0.09320	-0.092900	-0.007350	5.62e-01	9.63e-01
Signaling by KIT in disease	20	5.25e-01	6.09e-01	0.09300	0.064100	-0.067400	6.20e-01	6.02e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	5.25e-01	6.09e-01	0.09300	0.064100	-0.067400	6.20e-01	6.02e-01
IRS-related events triggered by IGF1R	35	7.34e-01	7.91e-01	0.09270	0.052700	0.076200	5.90e-01	4.35e-01
VEGFR2 mediated vascular permeability	26	4.50e-01	5.42e-01	0.09230	-0.049900	0.077700	6.60e-01	4.93e-01
Deactivation of the beta-catenin transactivating complex	36	4.35e-01	5.28e-01	0.09000	-0.088300	0.017300	3.59e-01	8.57e-01
Cardiac conduction	86	1.88e-01	2.75e-01	0.08970	-0.089600	0.003050	1.51e-01	9.61e-01
Viral Messenger RNA Synthesis	44	3.60e-01	4.56e-01	0.08960	0.018500	-0.087600	8.32e-01	3.14e-01
G alpha (q) signalling events	132	3.91e-02	8.11e-02	0.08950	-0.025000	0.085900	6.19e-01	8.82e-02
Condensation of Prometaphase Chromosomes	11	8.68e-01	9.00e-01	0.08840	0.022400	0.085500	8.97e-01	6.23e-01
Class I peroxisomal membrane protein import	20	6.03e-01	6.78e-01	0.08790	-0.081900	0.031900	5.26e-01	8.05e-01
Regulation of HSF1-mediated heat shock response	79	1.34e-01	2.13e-01	0.08770	0.033400	-0.081100	6.08e-01	2.13e-01
Signaling by NOTCH2	30	8.05e-01	8.45e-01	0.08750	0.064800	0.058900	5.39e-01	5.77e-01
IRS-mediated signalling	34	7.77e-01	8.23e-01	0.08740	0.054700	0.068100	5.81e-01	4.92e-01
Voltage gated Potassium channels	24	6.54e-01	7.24e-01	0.08690	-0.000413	0.086900	9.97e-01	4.61e-01
NRAGE signals death through JNK	52	2.40e-01	3.33e-01	0.08610	-0.066000	0.055300	4.10e-01	4.90e-01
Generic Transcription Pathway	1078	7.38e-04	2.68e-03	0.08580	-0.055800	-0.065300	2.00e-03	2.98e-04
Dual Incision in GG-NER	41	4.25e-01	5.20e-01	0.08540	0.016800	-0.083700	8.52e-01	3.54e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	5.68e-01	6.45e-01	0.08410	0.063900	0.054700	3.11e-01	3.86e-01
Cellular response to heat stress	93	1.27e-01	2.02e-01	0.08320	0.027900	-0.078500	6.43e-01	1.91e-01
Nuclear Envelope Breakdown	53	3.93e-01	4.88e-01	0.08230	0.008170	-0.081900	9.18e-01	3.03e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	7.52e-01	8.02e-01	0.08120	0.073800	0.033900	4.57e-01	7.32e-01
Heparan sulfate/heparin (HS-GAG) metabolism	37	4.70e-01	5.61e-01	0.08110	-0.023700	0.077500	8.03e-01	4.14e-01
Transport of Mature Transcript to Cytoplasm	81	1.82e-01	2.70e-01	0.08060	0.028200	-0.075600	6.61e-01	2.40e-01
Cell Cycle, Mitotic	500	1.33e-02	3.44e-02	0.08050	0.074600	0.030200	4.27e-03	2.48e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	37	7.98e-01	8.39e-01	0.08010	0.052700	0.060300	5.79e-01	5.26e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	6.26e-01	6.97e-01	0.07960	0.069900	0.038200	3.34e-01	5.97e-01
PI3K/AKT Signaling in Cancer	80	1.90e-01	2.79e-01	0.07840	-0.032500	0.071400	6.15e-01	2.70e-01
Recruitment of NuMA to mitotic centrosomes	79	6.12e-01	6.85e-01	0.07830	-0.045400	-0.063800	4.85e-01	3.27e-01
Epigenetic regulation of gene expression	100	2.87e-01	3.85e-01	0.07800	0.007610	0.077600	8.95e-01	1.80e-01
DNA Damage Recognition in GG-NER	38	6.01e-01	6.77e-01	0.07710	0.002130	0.077100	9.82e-01	4.11e-01
Centrosome maturation	80	6.12e-01	6.85e-01	0.07570	-0.040300	-0.064100	5.33e-01	3.22e-01
Recruitment of mitotic centrosome proteins and complexes	80	6.12e-01	6.85e-01	0.07570	-0.040300	-0.064100	5.33e-01	3.22e-01
TRP channels	17	8.99e-01	9.23e-01	0.07570	-0.064700	-0.039200	6.44e-01	7.80e-01
Peptide ligand-binding receptors	95	5.15e-01	6.02e-01	0.07560	0.067800	0.033300	2.53e-01	5.75e-01
Synthesis of PA	32	7.13e-01	7.72e-01	0.07480	0.012000	0.073800	9.06e-01	4.70e-01
Cytosolic sensors of pathogen-associated DNA	62	6.68e-01	7.36e-01	0.07450	0.065700	0.035000	3.71e-01	6.33e-01
Gene Silencing by RNA	88	4.82e-01	5.71e-01	0.07330	0.070100	0.021500	2.56e-01	7.27e-01
Metabolism of vitamins and cofactors	156	4.55e-01	5.45e-01	0.07290	0.055600	0.047100	2.31e-01	3.10e-01
Activation of BH3-only proteins	30	7.80e-01	8.25e-01	0.07230	0.069500	0.020300	5.10e-01	8.48e-01
Organelle biogenesis and maintenance	268	2.66e-01	3.62e-01	0.07210	0.055600	0.045800	1.17e-01	1.97e-01
Ovarian tumor domain proteases	37	7.47e-01	7.99e-01	0.07180	0.068400	0.021600	4.71e-01	8.20e-01
Meiosis	68	5.00e-01	5.88e-01	0.07120	0.008090	0.070700	9.08e-01	3.13e-01
TP53 Regulates Transcription of DNA Repair Genes	61	3.24e-01	4.18e-01	0.07090	-0.055500	0.044100	4.54e-01	5.51e-01
Reproduction	80	5.79e-01	6.56e-01	0.07080	0.026400	0.065700	6.83e-01	3.10e-01
Chromosome Maintenance	105	1.72e-01	2.59e-01	0.07040	0.029800	-0.063700	5.98e-01	2.59e-01
Lewis blood group biosynthesis	13	8.69e-01	9.00e-01	0.06990	-0.069800	-0.003170	6.63e-01	9.84e-01
Glucagon-type ligand receptors	20	7.30e-01	7.87e-01	0.06960	0.065100	-0.024500	6.14e-01	8.50e-01
Nucleotide-like (purinergic) receptors	13	8.94e-01	9.20e-01	0.06950	-0.068100	-0.013900	6.71e-01	9.31e-01
PI-3K cascade:FGFR2	12	8.16e-01	8.53e-01	0.06850	0.037700	-0.057200	8.21e-01	7.32e-01
Adaptive Immune System	753	2.04e-02	4.78e-02	0.06830	0.059700	0.033300	5.32e-03	1.20e-01
SUMO E3 ligases SUMOylate target proteins	159	3.47e-01	4.43e-01	0.06820	-0.064200	-0.023200	1.63e-01	6.13e-01
Nicotinate metabolism	25	6.50e-01	7.20e-01	0.06800	0.046200	-0.049900	6.89e-01	6.66e-01
Deposition of new CENPA-containing nucleosomes at the centromere	40	8.46e-01	8.79e-01	0.06650	0.049800	0.044100	5.86e-01	6.29e-01
Nucleosome assembly	40	8.46e-01	8.79e-01	0.06650	0.049800	0.044100	5.86e-01	6.29e-01
Gene expression (Transcription)	1325	3.24e-03	1.00e-02	0.06600	-0.036000	-0.055300	2.78e-02	7.28e-04
Anchoring of the basal body to the plasma membrane	96	6.77e-01	7.44e-01	0.06470	-0.040200	-0.050700	4.96e-01	3.91e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	6.78e-01	7.45e-01	0.06470	-0.058100	0.028500	6.01e-01	7.97e-01
SUMOylation	165	4.03e-01	4.99e-01	0.06370	-0.059100	-0.023700	1.90e-01	5.99e-01
G alpha (i) signalling events	243	4.00e-01	4.96e-01	0.06340	0.042100	0.047400	2.58e-01	2.04e-01
PI3K Cascade	30	7.62e-01	8.09e-01	0.06280	0.000823	0.062800	9.94e-01	5.52e-01
HSF1-dependent transactivation	29	8.13e-01	8.51e-01	0.06240	0.061400	0.011400	5.67e-01	9.15e-01
RNA Polymerase III Chain Elongation	18	9.08e-01	9.29e-01	0.06130	-0.021000	-0.057600	8.77e-01	6.72e-01
Cell Cycle	622	1.57e-02	3.97e-02	0.06130	0.060300	0.011200	1.03e-02	6.32e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	9.32e-01	9.49e-01	0.06080	-0.030300	-0.052700	8.29e-01	7.07e-01
TNF signaling	43	5.76e-01	6.54e-01	0.06070	0.053400	-0.028700	5.44e-01	7.45e-01
Loss of Nlp from mitotic centrosomes	68	7.90e-01	8.31e-01	0.06060	-0.044700	-0.041000	5.24e-01	5.59e-01
Loss of proteins required for interphase microtubule organization from the centrosome	68	7.90e-01	8.31e-01	0.06060	-0.044700	-0.041000	5.24e-01	5.59e-01
CDC6 association with the ORC:origin complex	11	8.64e-01	8.97e-01	0.06020	0.048600	-0.035600	7.80e-01	8.38e-01
Telomere Maintenance	80	4.85e-01	5.74e-01	0.05810	0.057700	-0.007370	3.73e-01	9.09e-01
Diseases associated with glycosaminoglycan metabolism	25	7.43e-01	7.95e-01	0.05800	-0.028800	0.050300	8.03e-01	6.63e-01
DNA Double-Strand Break Repair	135	6.70e-01	7.38e-01	0.05610	-0.037400	-0.041800	4.53e-01	4.02e-01
RNA Polymerase II Transcription	1197	3.31e-02	7.06e-02	0.05580	-0.035100	-0.043400	4.11e-02	1.16e-02
DAP12 signaling	28	7.56e-01	8.04e-01	0.05220	-0.042000	0.030900	7.00e-01	7.77e-01
Pregnenolone biosynthesis	10	9.19e-01	9.39e-01	0.05210	0.049600	-0.015700	7.86e-01	9.31e-01
Diseases of metabolism	185	6.05e-01	6.80e-01	0.05150	0.042500	0.029200	3.19e-01	4.94e-01
Other interleukin signaling	18	9.06e-01	9.29e-01	0.05080	0.050700	0.003900	7.10e-01	9.77e-01
FOXO-mediated transcription	59	7.35e-01	7.91e-01	0.04880	0.002470	0.048800	9.74e-01	5.17e-01
Downregulation of ERBB2:ERBB3 signaling	12	9.73e-01	9.81e-01	0.04860	0.030500	0.037800	8.55e-01	8.20e-01
Branched-chain amino acid catabolism	21	9.22e-01	9.41e-01	0.04760	0.010900	0.046300	9.31e-01	7.13e-01
Cilium Assembly	180	6.66e-01	7.34e-01	0.04690	-0.026300	-0.038800	5.43e-01	3.69e-01
RNA Polymerase III Transcription Initiation	36	8.93e-01	9.20e-01	0.04630	-0.043700	-0.015200	6.50e-01	8.74e-01
Homology Directed Repair	110	7.88e-01	8.31e-01	0.04630	-0.026800	-0.037700	6.27e-01	4.94e-01
Interleukin-2 signaling	11	9.77e-01	9.83e-01	0.04570	0.027600	0.036500	8.74e-01	8.34e-01
Visual phototransduction	59	6.59e-01	7.28e-01	0.04560	-0.019400	0.041300	7.97e-01	5.84e-01
Signaling by GPCR	534	6.64e-02	1.23e-01	0.04530	-0.003380	0.045100	8.94e-01	7.44e-02
Base Excision Repair	58	8.64e-01	8.97e-01	0.04480	-0.019100	-0.040600	8.02e-01	5.93e-01
The phototransduction cascade	26	9.39e-01	9.52e-01	0.04470	-0.039900	-0.020100	7.25e-01	8.59e-01
Kinesins	39	9.01e-01	9.25e-01	0.04430	-0.041100	-0.016700	6.57e-01	8.57e-01
GPCR downstream signalling	489	1.11e-01	1.84e-01	0.04360	-0.001320	0.043600	9.60e-01	9.88e-02
Interleukin-35 Signalling	12	9.79e-01	9.84e-01	0.04340	-0.031500	-0.029800	8.50e-01	8.58e-01
G2/M DNA damage checkpoint	67	7.58e-01	8.05e-01	0.04300	0.043000	0.001350	5.43e-01	9.85e-01
Interleukin-7 signaling	21	9.59e-01	9.68e-01	0.04270	0.022200	0.036500	8.60e-01	7.72e-01
Regulation of TP53 Expression and Degradation	36	9.28e-01	9.46e-01	0.04260	-0.037200	-0.020800	6.99e-01	8.29e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	9.42e-01	9.53e-01	0.04210	0.028800	0.030700	7.65e-01	7.50e-01
Diseases of mitotic cell cycle	36	9.42e-01	9.53e-01	0.04210	0.028800	0.030700	7.65e-01	7.50e-01
Regulation of TP53 Activity through Phosphorylation	88	6.98e-01	7.60e-01	0.04170	0.000461	-0.041700	9.94e-01	4.99e-01
G alpha (s) signalling events	137	7.87e-01	8.31e-01	0.04150	0.034000	0.023800	4.92e-01	6.30e-01
Signaling by BMP	21	8.98e-01	9.23e-01	0.04100	0.039500	-0.011000	7.54e-01	9.30e-01
AURKA Activation by TPX2	71	8.91e-01	9.19e-01	0.04040	-0.032600	-0.023900	6.35e-01	7.27e-01
RNA Polymerase III Abortive And Retractive Initiation	41	9.37e-01	9.52e-01	0.03920	0.022200	0.032400	8.06e-01	7.20e-01
RNA Polymerase III Transcription	41	9.37e-01	9.52e-01	0.03920	0.022200	0.032400	8.06e-01	7.20e-01
GPCR ligand binding	231	5.53e-01	6.32e-01	0.03850	-0.008240	-0.037600	8.29e-01	3.25e-01
Class A/1 (Rhodopsin-like receptors)	166	5.46e-01	6.27e-01	0.03830	0.002260	-0.038300	9.60e-01	3.95e-01
Processing of DNA double-strand break ends	71	8.75e-01	9.05e-01	0.03810	0.034800	0.015500	6.12e-01	8.21e-01
Transcriptional Regulation by VENTX	38	8.38e-01	8.73e-01	0.03580	-0.029900	0.019700	7.50e-01	8.33e-01
Regulation of TP53 Degradation	35	9.09e-01	9.30e-01	0.03570	-0.035600	-0.002490	7.16e-01	9.80e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	31	8.73e-01	9.03e-01	0.03510	-0.018400	0.029900	8.60e-01	7.73e-01
CRMPs in Sema3A signaling	14	9.39e-01	9.52e-01	0.03500	0.021800	-0.027400	8.88e-01	8.59e-01
HCMV Early Events	74	7.90e-01	8.31e-01	0.03480	-0.003830	0.034600	9.55e-01	6.07e-01
Metabolism of water-soluble vitamins and cofactors	110	7.03e-01	7.64e-01	0.03470	0.034400	-0.004330	5.33e-01	9.37e-01
Cell-cell junction organization	38	8.89e-01	9.18e-01	0.03450	0.003410	-0.034300	9.71e-01	7.15e-01
RHO GTPases Activate Formins	117	7.06e-01	7.66e-01	0.03380	-0.003390	0.033700	9.49e-01	5.29e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	9.58e-01	9.68e-01	0.03230	0.002400	-0.032300	9.87e-01	8.23e-01
Mitotic Spindle Checkpoint	108	7.71e-01	8.17e-01	0.03190	0.031900	-0.000500	5.66e-01	9.93e-01
ADORA2B mediated anti-inflammatory cytokines production	72	8.23e-01	8.59e-01	0.03150	0.031200	-0.004490	6.47e-01	9.47e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	9.74e-01	9.81e-01	0.03120	0.023400	0.020700	8.30e-01	8.50e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	25	9.25e-01	9.43e-01	0.03120	-0.010400	0.029400	9.28e-01	7.99e-01
Mitotic Prometaphase	184	8.18e-01	8.55e-01	0.03010	-0.013600	-0.026900	7.51e-01	5.29e-01
Diseases of glycosylation	106	9.14e-01	9.35e-01	0.02990	-0.022200	-0.020100	6.93e-01	7.21e-01
SLC transporter disorders	75	8.09e-01	8.47e-01	0.02970	0.028000	-0.010000	6.75e-01	8.81e-01
Resolution of Sister Chromatid Cohesion	104	8.93e-01	9.20e-01	0.02870	0.026400	0.011100	6.42e-01	8.45e-01
HS-GAG degradation	16	9.89e-01	9.92e-01	0.02710	0.017100	0.020900	9.05e-01	8.85e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	9.93e-01	9.95e-01	0.02570	0.019000	0.017300	9.13e-01	9.21e-01
Constitutive Signaling by Aberrant PI3K in Cancer	53	9.06e-01	9.29e-01	0.02300	-0.011400	0.020000	8.86e-01	8.01e-01
DNA Repair	289	8.67e-01	8.99e-01	0.02230	-0.018100	-0.013000	5.97e-01	7.04e-01
Netrin-1 signaling	40	9.55e-01	9.66e-01	0.02140	-0.001390	0.021400	9.88e-01	8.15e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	9.38e-01	9.52e-01	0.02130	-0.006200	-0.020300	9.19e-01	7.37e-01
Amplification of signal from the kinetochores	91	9.38e-01	9.52e-01	0.02130	-0.006200	-0.020300	9.19e-01	7.37e-01
Activation of SMO	13	9.91e-01	9.94e-01	0.02090	-0.019900	-0.006400	9.01e-01	9.68e-01
Regulation of PLK1 Activity at G2/M Transition	86	8.99e-01	9.23e-01	0.02020	0.005360	-0.019500	9.32e-01	7.55e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	79	9.69e-01	9.77e-01	0.01990	0.016300	0.011500	8.03e-01	8.59e-01
Class B/2 (Secretin family receptors)	55	9.39e-01	9.52e-01	0.01910	-0.018200	0.005820	8.16e-01	9.41e-01
Telomere Extension By Telomerase	23	9.81e-01	9.85e-01	0.01530	0.012300	-0.008970	9.18e-01	9.41e-01
Inactivation, recovery and regulation of the phototransduction cascade	25	9.96e-01	9.97e-01	0.01180	-0.009970	-0.006340	9.31e-01	9.56e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	9.75e-01	9.81e-01	0.01010	0.000370	-0.010100	9.95e-01	8.59e-01
EML4 and NUDC in mitotic spindle formation	95	9.93e-01	9.95e-01	0.00464	0.001970	-0.004190	9.73e-01	9.44e-01
Chondroitin sulfate/dermatan sulfate metabolism	38	9.99e-01	9.99e-01	0.00279	-0.002730	-0.000567	9.77e-01	9.95e-01

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Detailed Gene set reports

IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)

metric	value
setSize	10
pMANOVA	1.45e-06
p.adjustMANOVA	9.18e-06
s.dist	1.19
s.low.CRP	0.813
s.high.CRP	0.875
p.low.CRP	8.51e-06
p.high.CRP	1.65e-06

Top 20 genes

Gene	low CRP	high CRP
CD36	10363	10493
CD14	10063	10306
TLR2	10239	9881
TLR4	9286	10255
TLR1	10059	9241
LY96	9677	9581
TLR6	9187	9277
MYD88	8926	8524
BTK	5823	9633

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
BTK	5823	9633
CD14	10063	10306
CD36	10363	10493
LY96	9677	9581
MYD88	8926	8524
TIRAP	-8	6185
TLR1	10059	9241
TLR2	10239	9881
TLR4	9286	10255
TLR6	9187	9277

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MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)

metric	value
setSize	10
pMANOVA	1.45e-06
p.adjustMANOVA	9.18e-06
s.dist	1.19
s.low.CRP	0.813
s.high.CRP	0.875
p.low.CRP	8.51e-06
p.high.CRP	1.65e-06

Top 20 genes

Gene	low CRP	high CRP
CD36	10363	10493
CD14	10063	10306
TLR2	10239	9881
TLR4	9286	10255
TLR1	10059	9241
LY96	9677	9581
TLR6	9187	9277
MYD88	8926	8524
BTK	5823	9633

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
BTK	5823	9633
CD14	10063	10306
CD36	10363	10493
LY96	9677	9581
MYD88	8926	8524
TIRAP	-8	6185
TLR1	10059	9241
TLR2	10239	9881
TLR4	9286	10255
TLR6	9187	9277

---

---

Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand

metric	value
setSize	11
pMANOVA	4.26e-06
p.adjustMANOVA	2.48e-05
s.dist	1.09
s.low.CRP	0.798
s.high.CRP	0.746
p.low.CRP	4.59e-06
p.high.CRP	1.81e-05

Top 20 genes

Gene	low CRP	high CRP
S100A8	10362	10564
S100A9	10316	10598
CD36	10363	10493
CD14	10063	10306
TLR2	10239	9881
TLR4	9286	10255
TLR1	10059	9241
LY96	9677	9581
TLR6	9187	9277
HMGB1	3409	1050

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CD14	10063	10306
CD36	10363	10493
HMGB1	3409	1050
LY96	9677	9581
S100A1	-2763	-3665
S100A8	10362	10564
S100A9	10316	10598
TLR1	10059	9241
TLR2	10239	9881
TLR4	9286	10255
TLR6	9187	9277

---

---

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

metric	value
setSize	12
pMANOVA	2.22e-06
p.adjustMANOVA	1.37e-05
s.dist	1.07
s.low.CRP	0.713
s.high.CRP	0.798
p.low.CRP	1.9e-05
p.high.CRP	1.69e-06

Top 20 genes

Gene	low CRP	high CRP
ACSL1	10178	9937
HSD17B4	9650	10264
ELOVL3	10220	9260
ACOX1	9058	9176
ACAA1	7355	9532
FADS1	6968	9327
ACOT8	5734	9612
SCP2	7718	6645
ELOVL1	5593	8179
ABCD1	5996	7409
ELOVL5	7670	5549
FADS2	1344	7263

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ABCD1	5996	7409
ACAA1	7355	9532
ACOT8	5734	9612
ACOX1	9058	9176
ACSL1	10178	9937
ELOVL1	5593	8179
ELOVL3	10220	9260
ELOVL5	7670	5549
FADS1	6968	9327
FADS2	1344	7263
HSD17B4	9650	10264
SCP2	7718	6645

---

---

alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism

metric	value
setSize	12
pMANOVA	2.22e-06
p.adjustMANOVA	1.37e-05
s.dist	1.07
s.low.CRP	0.713
s.high.CRP	0.798
p.low.CRP	1.9e-05
p.high.CRP	1.69e-06

Top 20 genes

Gene	low CRP	high CRP
ACSL1	10178	9937
HSD17B4	9650	10264
ELOVL3	10220	9260
ACOX1	9058	9176
ACAA1	7355	9532
FADS1	6968	9327
ACOT8	5734	9612
SCP2	7718	6645
ELOVL1	5593	8179
ABCD1	5996	7409
ELOVL5	7670	5549
FADS2	1344	7263

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ABCD1	5996	7409
ACAA1	7355	9532
ACOT8	5734	9612
ACOX1	9058	9176
ACSL1	10178	9937
ELOVL1	5593	8179
ELOVL3	10220	9260
ELOVL5	7670	5549
FADS1	6968	9327
FADS2	1344	7263
HSD17B4	9650	10264
SCP2	7718	6645

---

---

Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse

metric	value
setSize	24
pMANOVA	2.61e-11
p.adjustMANOVA	4.87e-10
s.dist	0.987
s.low.CRP	-0.55
s.high.CRP	-0.819
p.low.CRP	3.1e-06
p.high.CRP	3.6e-12

Top 20 genes

Gene	low CRP	high CRP
CD247	-10994	-10515
HLA-DPB1	-10605	-10638
HLA-DPA1	-10572	-10652
TRBC1	-10279	-10323
ZAP70	-10072	-10388
LCK	-9185	-10569
HLA-DRA	-8799	-10557
TRAV19	-8655	-10178
CD3G	-8283	-10568
CD3D	-7327	-10481
TRAV8-4	-7052	-9962
HLA-DQB2	-7036	-9597
HLA-DQA1	-5841	-10469
TRBV12-3	-5797	-9067
CD3E	-4636	-10489
HLA-DRB5	-5253	-8129
TRAC	-3310	-10643
HLA-DRB1	-3832	-8988
TRBV7-9	-3767	-6477
HLA-DQA2	-4322	-3258

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CD247	-10994	-10515
CD3D	-7327	-10481
CD3E	-4636	-10489
CD3G	-8283	-10568
CD4	1506	-6863
HLA-DPA1	-10572	-10652
HLA-DPB1	-10605	-10638
HLA-DQA1	-5841	-10469
HLA-DQA2	-4322	-3258
HLA-DQB1	2746	-7642
HLA-DQB2	-7036	-9597
HLA-DRA	-8799	-10557
HLA-DRB1	-3832	-8988
HLA-DRB5	-5253	-8129
LCK	-9185	-10569
PTPN22	-7799	6117
TRAC	-3310	-10643
TRAV19	-8655	-10178
TRAV29DV5	83	-10423
TRAV8-4	-7052	-9962
TRBC1	-10279	-10323
TRBV12-3	-5797	-9067
TRBV7-9	-3767	-6477
ZAP70	-10072	-10388

---

---

Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen

metric	value
setSize	11
pMANOVA	0.000114
p.adjustMANOVA	0.000496
s.dist	0.938
s.low.CRP	0.67
s.high.CRP	0.656
p.low.CRP	0.000119
p.high.CRP	0.000164

Top 20 genes

Gene	low CRP	high CRP
CYB5R1	10052	10467
CA1	10237	10011
CYB5R4	9627	9455
SLC4A1	9896	9193
CYB5R2	8769	10354
HBA1	9695	8704
CA4	7084	9371
HBB	9671	6093
AQP1	7854	7172
CA2	1256	5218

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
AQP1	7854	7172
CA1	10237	10011
CA2	1256	5218
CA4	7084	9371
CYB5R1	10052	10467
CYB5R2	8769	10354
CYB5R4	9627	9455
CYB5RL	-8983	-9075
HBA1	9695	8704
HBB	9671	6093
SLC4A1	9896	9193

---

---

O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes

metric	value
setSize	11
pMANOVA	0.000114
p.adjustMANOVA	0.000496
s.dist	0.938
s.low.CRP	0.67
s.high.CRP	0.656
p.low.CRP	0.000119
p.high.CRP	0.000164

Top 20 genes

Gene	low CRP	high CRP
CYB5R1	10052	10467
CA1	10237	10011
CYB5R4	9627	9455
SLC4A1	9896	9193
CYB5R2	8769	10354
HBA1	9695	8704
CA4	7084	9371
HBB	9671	6093
AQP1	7854	7172
CA2	1256	5218

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
AQP1	7854	7172
CA1	10237	10011
CA2	1256	5218
CA4	7084	9371
CYB5R1	10052	10467
CYB5R2	8769	10354
CYB5R4	9627	9455
CYB5RL	-8983	-9075
HBA1	9695	8704
HBB	9671	6093
SLC4A1	9896	9193

---

---

Hyaluronan uptake and degradation

Hyaluronan uptake and degradation

metric	value
setSize	12
pMANOVA	6.18e-05
p.adjustMANOVA	0.000286
s.dist	0.9
s.low.CRP	0.537
s.high.CRP	0.722
p.low.CRP	0.00129
p.high.CRP	1.48e-05

Top 20 genes

Gene	low CRP	high CRP
HEXB	9686	9967
CHP1	8833	10625
HYAL2	8701	10550
CD44	9109	9660
LYVE1	7916	9920
STAB2	6753	7249
GUSB	3888	9979
HYAL3	8070	4386
HMMR	3097	4182
SLC9A1	1175	9205
HEXA	1499	2409

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CD44	9109	9660
CHP1	8833	10625
GUSB	3888	9979
HEXA	1499	2409
HEXB	9686	9967
HMMR	3097	4182
HYAL1	-3857	4281
HYAL2	8701	10550
HYAL3	8070	4386
LYVE1	7916	9920
SLC9A1	1175	9205
STAB2	6753	7249

---

---

Uptake and function of anthrax toxins

Uptake and function of anthrax toxins

metric	value
setSize	10
pMANOVA	0.000579
p.adjustMANOVA	0.00215
s.dist	0.865
s.low.CRP	0.518
s.high.CRP	0.693
p.low.CRP	0.00459
p.high.CRP	0.000147

Top 20 genes

Gene	low CRP	high CRP
MAP2K1	8861	10365
MAP2K6	8704	10103
FURIN	7688	10324
PDCD6IP	8622	9034
MAP2K3	8777	8502
MAP2K4	5525	7430
ANTXR2	4925	7379
MAP2K2	4832	6767

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ANTXR2	4925	7379
CALM1	-4337	1051
FURIN	7688	10324
MAP2K1	8861	10365
MAP2K2	4832	6767
MAP2K3	8777	8502
MAP2K4	5525	7430
MAP2K6	8704	10103
MAP2K7	-1568	2972
PDCD6IP	8622	9034

---

---

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

metric	value
setSize	11
pMANOVA	0.000117
p.adjustMANOVA	0.000501
s.dist	0.842
s.low.CRP	0.403
s.high.CRP	0.739
p.low.CRP	0.0206
p.high.CRP	2.17e-05

Top 20 genes

Gene	low CRP	high CRP
FZD5	10298	10651
CLTC	9482	10359
CLTA	9206	9264
AP2S1	8593	9630
AP2M1	7928	9269
AP2A2	5529	9467
FZD2	6397	6508
CLTB	891	6664

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
AP2A1	-5326	9611
AP2A2	5529	9467
AP2B1	-8369	3155
AP2M1	7928	9269
AP2S1	8593	9630
CLTA	9206	9264
CLTB	891	6664
CLTC	9482	10359
FZD2	6397	6508
FZD5	10298	10651
ROR1	-854	2172

---

---

Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling

metric	value
setSize	12
pMANOVA	0.000206
p.adjustMANOVA	0.000837
s.dist	0.841
s.low.CRP	0.501
s.high.CRP	0.676
p.low.CRP	0.00265
p.high.CRP	5.01e-05

Top 20 genes

Gene	low CRP	high CRP
S100A12	10367	10617
APP	10085	9961
MAPK3	9769	9676
LGALS3	9840	9259
CAPZA2	10077	9039
CAPZA1	9332	9316
DDOST	5768	8734
PRKCSH	1054	6027
AGER	1815	2573
HMGB1	3409	1050

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
AGER	1815	2573
APP	10085	9961
CAPZA1	9332	9316
CAPZA2	10077	9039
DDOST	5768	8734
HMGB1	3409	1050
LGALS3	9840	9259
MAPK1	-1086	9427
MAPK3	9769	9676
PRKCSH	1054	6027
S100A12	10367	10617
S100B	-10129	814

---

---

p130Cas linkage to MAPK signaling for integrins

p130Cas linkage to MAPK signaling for integrins

metric	value
setSize	11
pMANOVA	0.000877
p.adjustMANOVA	0.00311
s.dist	0.824
s.low.CRP	0.56
s.high.CRP	0.605
p.low.CRP	0.00131
p.high.CRP	0.000514

Top 20 genes

Gene	low CRP	high CRP
APBB1IP	10051	8873
CRK	9214	9663
ITGA2B	8831	9692
RAP1A	9691	8186
ITGB3	7696	8680
FN1	9912	6648
TLN1	5974	9916
VWF	3995	7559
PTK2	4992	3213

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
APBB1IP	10051	8873
CRK	9214	9663
FN1	9912	6648
ITGA2B	8831	9692
ITGB3	7696	8680
PTK2	4992	3213
RAP1A	9691	8186
RAP1B	-3254	7324
SRC	-4936	-8846
TLN1	5974	9916
VWF	3995	7559

---

---

Detoxification of Reactive Oxygen Species

Detoxification of Reactive Oxygen Species

metric	value
setSize	31
pMANOVA	4.79e-09
p.adjustMANOVA	4.6e-08
s.dist	0.807
s.low.CRP	0.605
s.high.CRP	0.533
p.low.CRP	5.35e-09
p.high.CRP	2.73e-07

Top 20 genes

Gene	low CRP	high CRP
PRDX3	10333	10346
NCF2	10167	10265
NCF4	10090	10097
CYBB	10294	9839
GSR	9685	10272
CAT	9642	9941
GPX1	9841	9615
ERO1A	10293	8674
P4HB	8507	9962
PRDX5	9532	8827
PRDX6	9478	8747
TXN	9660	8103
TXNRD1	8785	8833
PRDX1	9223	7690
TXNRD2	9039	7340
TXN2	7093	6979
CYBA	5409	8122
NUDT2	6788	5035
NCF1	7986	3322
SOD2	9488	2250

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ATOX1	2131	5843
ATP7A	-7540	3791
CAT	9642	9941
CCS	1445	4651
CYBA	5409	8122
CYBB	10294	9839
CYCS	7831	2324
ERO1A	10293	8674
GPX1	9841	9615
GPX2	-1463	-2988
GPX3	-5701	2619
GPX7	-227	-6599
GSR	9685	10272
GSTP1	2629	-1335
NCF1	7986	3322
NCF2	10167	10265
NCF4	10090	10097
NOX5	-2379	5051
NUDT2	6788	5035
P4HB	8507	9962
PRDX1	9223	7690
PRDX2	8560	1885
PRDX3	10333	10346
PRDX5	9532	8827
PRDX6	9478	8747
SOD1	3597	-3501
SOD2	9488	2250
TXN	9660	8103
TXN2	7093	6979
TXNRD1	8785	8833
TXNRD2	9039	7340

---

---

ROS and RNS production in phagocytes

ROS and RNS production in phagocytes

metric	value
setSize	31
pMANOVA	4.57e-09
p.adjustMANOVA	4.45e-08
s.dist	0.806
s.low.CRP	0.61
s.high.CRP	0.528
p.low.CRP	4.14e-09
p.high.CRP	3.65e-07

Top 20 genes

Gene	low CRP	high CRP
ATP6V0A1	10207	10551
ATP6V1A	10093	10441
NCF2	10167	10265
ATP6V0D1	10069	10341
SLC11A1	9804	10582
ATP6V1B2	10130	10122
NCF4	10090	10097
CYBB	10294	9839
ATP6V1D	9919	9993
ATP6V1C1	10266	9394
ATP6V0C	9621	9869
ATP6V0B	9087	9653
ATP6V0E1	8986	9188
ATP6V1E1	9071	8178
ATP6V1H	8628	8476
ATP6V1F	8059	6808
ATP6V1E2	9253	5767
MPO	10011	5205
CYBA	5409	8122
LPO	5708	5822

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ATP6V0A1	10207	10551
ATP6V0A2	-10746	-8412
ATP6V0B	9087	9653
ATP6V0C	9621	9869
ATP6V0D1	10069	10341
ATP6V0E1	8986	9188
ATP6V0E2	-4949	-10370
ATP6V1A	10093	10441
ATP6V1B2	10130	10122
ATP6V1C1	10266	9394
ATP6V1C2	-1408	-231
ATP6V1D	9919	9993
ATP6V1E1	9071	8178
ATP6V1E2	9253	5767
ATP6V1F	8059	6808
ATP6V1G1	7364	3710
ATP6V1G2	-3663	-8648
ATP6V1H	8628	8476
CYBA	5409	8122
CYBB	10294	9839
HVCN1	5605	5771
LPO	5708	5822
MPO	10011	5205
NCF1	7986	3322
NCF2	10167	10265
NCF4	10090	10097
NOS1	-86	528
NOS3	7751	-4608
RAC2	-1305	4460
SLC11A1	9804	10582
TCIRG1	253	9871

---

---

Unwinding of DNA

Unwinding of DNA

metric	value
setSize	12
pMANOVA	0.000492
p.adjustMANOVA	0.00185
s.dist	0.804
s.low.CRP	-0.492
s.high.CRP	-0.635
p.low.CRP	0.00317
p.high.CRP	0.000138

Top 20 genes

Gene	low CRP	high CRP
MCM3	-10075	-10239
MCM7	-9821	-10045
MCM8	-10841	-8828
GINS4	-8376	-9396
MCM6	-4104	-8763
MCM4	-3439	-7636
GINS1	-5759	-4460
MCM2	-4416	-5719
MCM5	-9699	-2337
GINS3	-2954	-4814

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CDC45	1161	-4835
GINS1	-5759	-4460
GINS2	1174	-4751
GINS3	-2954	-4814
GINS4	-8376	-9396
MCM2	-4416	-5719
MCM3	-10075	-10239
MCM4	-3439	-7636
MCM5	-9699	-2337
MCM6	-4104	-8763
MCM7	-9821	-10045
MCM8	-10841	-8828

---

---

Insulin receptor recycling

Insulin receptor recycling

metric	value
setSize	21
pMANOVA	3.68e-06
p.adjustMANOVA	2.16e-05
s.dist	0.797
s.low.CRP	0.568
s.high.CRP	0.559
p.low.CRP	6.62e-06
p.high.CRP	9.21e-06

Top 20 genes

Gene	low CRP	high CRP
ATP6V0A1	10207	10551
ATP6V1A	10093	10441
ATP6V0D1	10069	10341
ATP6V1B2	10130	10122
ATP6V1D	9919	9993
ATP6V1C1	10266	9394
ATP6V0C	9621	9869
ATP6V0B	9087	9653
ATP6V0E1	8986	9188
ATP6V1E1	9071	8178
ATP6V1H	8628	8476
INSR	6229	10310
ATP6V1F	8059	6808
ATP6V1E2	9253	5767
ATP6AP1	4019	10005
ATP6V1G1	7364	3710
TCIRG1	253	9871

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ATP6AP1	4019	10005
ATP6V0A1	10207	10551
ATP6V0A2	-10746	-8412
ATP6V0B	9087	9653
ATP6V0C	9621	9869
ATP6V0D1	10069	10341
ATP6V0E1	8986	9188
ATP6V0E2	-4949	-10370
ATP6V1A	10093	10441
ATP6V1B2	10130	10122
ATP6V1C1	10266	9394
ATP6V1C2	-1408	-231
ATP6V1D	9919	9993
ATP6V1E1	9071	8178
ATP6V1E2	9253	5767
ATP6V1F	8059	6808
ATP6V1G1	7364	3710
ATP6V1G2	-3663	-8648
ATP6V1H	8628	8476
INSR	6229	10310
TCIRG1	253	9871

---

---

PD-1 signaling

PD-1 signaling

metric	value
setSize	28
pMANOVA	2.29e-09
p.adjustMANOVA	2.38e-08
s.dist	0.781
s.low.CRP	-0.372
s.high.CRP	-0.687
p.low.CRP	0.000663
p.high.CRP	3.12e-10

Top 20 genes

Gene	low CRP	high CRP
CD247	-10994	-10515
HLA-DPB1	-10605	-10638
HLA-DPA1	-10572	-10652
TRBC1	-10279	-10323
LCK	-9185	-10569
HLA-DRA	-8799	-10557
TRAV19	-8655	-10178
CD3G	-8283	-10568
CD3D	-7327	-10481
TRAV8-4	-7052	-9962
HLA-DQB2	-7036	-9597
HLA-DQA1	-5841	-10469
PDCD1	-7335	-8133
TRBV12-3	-5797	-9067
CD3E	-4636	-10489
HLA-DRB5	-5253	-8129
TRAC	-3310	-10643
HLA-DRB1	-3832	-8988
TRBV7-9	-3767	-6477
HLA-DQA2	-4322	-3258

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CD247	-10994	-10515
CD274	7804	-10162
CD3D	-7327	-10481
CD3E	-4636	-10489
CD3G	-8283	-10568
CD4	1506	-6863
CSK	-2015	6501
HLA-DPA1	-10572	-10652
HLA-DPB1	-10605	-10638
HLA-DQA1	-5841	-10469
HLA-DQA2	-4322	-3258
HLA-DQB1	2746	-7642
HLA-DQB2	-7036	-9597
HLA-DRA	-8799	-10557
HLA-DRB1	-3832	-8988
HLA-DRB5	-5253	-8129
LCK	-9185	-10569
PDCD1	-7335	-8133
PDCD1LG2	5488	-5475
PTPN11	3471	9688
PTPN6	3230	7923
TRAC	-3310	-10643
TRAV19	-8655	-10178
TRAV29DV5	83	-10423
TRAV8-4	-7052	-9962
TRBC1	-10279	-10323
TRBV12-3	-5797	-9067
TRBV7-9	-3767	-6477

---

---

Neutrophil degranulation

Neutrophil degranulation

metric	value
setSize	456
pMANOVA	5.75e-107
p.adjustMANOVA	7.84e-104
s.dist	0.76
s.low.CRP	0.536
s.high.CRP	0.539
p.low.CRP	3.01e-86
p.high.CRP	2.42e-87

Top 20 genes

Gene	low CRP	high CRP
RNASE2	10359	10657
IDH1	10341	10649
S100A12	10367	10617
MGST1	10318	10658
CTSA	10310	10636
SIRPA	10351	10576
S100A8	10362	10564
S100A9	10316	10598
MCEMP1	10355	10554
CD93	10231	10668
CR1	10309	10566
CD36	10363	10493
SERPINB1	10330	10507
PGAM1	10347	10422
HP	10242	10523
ATP6V0A1	10207	10551
LAMTOR1	10275	10468
FPR1	10352	10383
CREG1	10146	10578
PLD1	10119	10572

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
A1BG	7201	6324
ABCA13	9337	4245
ACAA1	7355	9532
ACLY	-3480	8333
ACTR10	9447	8995
ACTR1B	-9174	-7104
ACTR2	9004	9240
ADAM10	9652	10284
ADAM8	1203	2391
ADGRE3	-6203	-8538
ADGRE5	-10156	-1430
ADGRG3	4594	7820
AGA	-8931	1617
AGL	-5887	971
AGPAT2	9571	10463
ALAD	5688	9906
ALDH3B1	9122	10008
ALDOA	10140	10121
ALDOC	3900	-6356
ALOX5	9735	9772
AMPD3	8883	9878
ANO6	7295	8568
ANPEP	10206	10073
ANXA2	9791	10138
AOC1	4561	3551
AP1M1	392	8050
AP2A2	5529	9467
APAF1	9662	9512
APEH	-6699	1881
APRT	3186	-4197
ARG1	9516	8264
ARHGAP9	-4182	7692
ARL8A	9465	8775
ARMC8	9323	7367
ARPC5	9932	9762
ARSA	6282	1069
ARSB	8290	9046
ASAH1	9394	10144
ATAD3B	-4315	-7816
ATG7	9954	8519
ATP11A	6284	9116
ATP11B	-350	6286
ATP6AP2	9781	8803
ATP6V0A1	10207	10551
ATP6V0C	9621	9869
ATP6V1D	9919	9993
ATP8A1	-10266	-10371
ATP8B4	7565	8129
AZU1	9907	1592
B2M	58	-7420
B4GALT1	-3872	6820
BIN2	-8436	8915
BPI	9742	5505
BRI3	8728	10115
BST1	10348	10335
BST2	-3420	-6690
C3	-10957	-10571
C3AR1	8008	9376
C5AR1	9773	10201
C6orf120	5027	7382
CAB39	9229	8388
CAMP	4319	-2875
CAND1	1355	-1576
CANT1	6929	6926
CAP1	9134	8626
CAPN1	5416	9742
CAT	9642	9941
CCT2	6166	-5938
CCT8	9483	8073
CD14	10063	10306
CD177	9884	10435
CD300A	-7444	-2295
CD33	9741	8810
CD36	10363	10493
CD44	9109	9660
CD47	-8631	-9598
CD53	7763	9356
CD55	9747	10312
CD58	8027	7845
CD59	6386	4199
CD63	9814	10489
CD68	9480	10077
CD93	10231	10668
CDA	10040	10360
CDK13	-10473	-1209
CEACAM1	8525	8200
CEACAM3	5874	4896
CEACAM6	9295	4203
CEACAM8	9490	3624
CEP290	515	-6593
CFD	911	-342
CFP	8398	8912
CHI3L1	6877	-4064
CHIT1	9419	6195
CKAP4	10349	9973
CLEC12A	7370	3483
CLEC4C	-10672	-8976
CLEC4D	10190	9618
CLEC5A	9868	9360
CMTM6	9160	8256
CNN2	4530	6242
COMMD3	3550	2189
COMMD9	9687	9081
COPB1	9548	8670
COTL1	8714	9141
CPNE1	-7255	-6504
CPNE3	8631	6794
CPPED1	9095	9222
CR1	10309	10566
CRACR2A	-10855	-4635
CREG1	10146	10578
CRISP3	5459	7621
CRISPLD2	9797	10342
CSNK2B	4787	4600
CST3	5014	-1198
CSTB	7160	8738
CTSA	10310	10636
CTSB	9828	10631
CTSC	-3910	5638
CTSD	9997	10635
CTSG	9668	2004
CTSH	9551	7551
CTSS	10120	8325
CTSZ	9796	10451
CXCL1	7627	4227
CXCR1	3353	4270
CXCR2	5266	1302
CYB5R3	7459	10015
CYBA	5409	8122
CYBB	10294	9839
CYFIP1	10019	10571
CYSTM1	10132	9426
DBNL	4127	8290
DDOST	5768	8734
DDX3X	7864	5693
DEFA1	9522	5409
DEFA4	9728	4397
DEGS1	8935	6383
DERA	9456	9825
DGAT1	879	2318
DIAPH1	-9285	3050
DNAJC13	8999	9866
DNAJC3	9070	9215
DNAJC5	8864	9763
DNASE1L1	7707	10229
DOCK2	3702	9336
DOK3	10044	10449
DPP7	-979	-5002
DSC1	3313	-7945
DSN1	-8664	-5515
DSP	-4419	-1253
DYNC1H1	-9811	-4718
DYNC1LI1	8227	7194
DYNLL1	6414	7208
DYNLT1	6878	3642
EEF1A1	2936	-4796
EEF2	-3419	-1260
ELANE	10082	5779
ENPP4	-10352	-5923
EPX	784	-848
ERP44	9756	6863
FABP5	6772	7102
FAF2	3745	8707
FCAR	10261	9489
FCER1G	9338	9547
FCGR2A	9647	9000
FCGR3B	5213	-2356
FCN1	10313	9522
FGL2	9767	-4215
FGR	7776	10127
FOLR3	8487	6843
FPR1	10352	10383
FPR2	10305	10056
FRK	-3103	1427
FRMPD3	-10958	-9622
FTH1	1622	1016
FTL	9418	9788
FUCA1	9326	10044
FUCA2	9523	9365
GAA	8463	8516
GALNS	6891	7996
GCA	10340	10301
GDI2	8435	8742
GGH	7094	6779
GHDC	425	764
GLA	7742	9617
GLB1	9395	10125
GLIPR1	10116	7714
GM2A	9951	10624
GMFG	8707	8365
GNS	9753	10593
GOLGA7	5151	3331
GPI	3695	7384
GPR84	10189	9570
GRN	10105	10416
GSDMD	4103	-1714
GSN	10108	9436
GSTP1	2629	-1335
GUSB	3888	9979
GYG1	9967	10059
HBB	9671	6093
HEBP2	7929	9318
HEXB	9686	9967
HGSNAT	2790	2412
HK3	10197	10277
HLA-A	-3294	-7605
HLA-B	5549	-2345
HLA-C	1664	-2812
HLA-H	-8262	-1093
HMGB1	3409	1050
HMOX2	-9635	-10507
HP	10242	10523
HPSE	9308	10055
HRNR	-8222	-7950
HSP90AA1	5650	1245
HSP90AB1	4616	-5342
HSPA1A	8518	7125
HSPA1B	4687	5369
HSPA6	4663	3881
HSPA8	-4222	-8984
HUWE1	-9990	-3993
HVCN1	5605	5771
IDH1	10341	10649
IGF2R	-5530	9230
ILF2	6408	2915
IMPDH1	10166	10137
IMPDH2	543	-9049
IQGAP1	6734	9841
IQGAP2	3533	9892
IST1	2776	6310
ITGAL	-10521	-8351
ITGAM	10114	10483
ITGAV	4141	7107
ITGAX	4703	8540
ITGB2	9132	10614
JUP	-10174	-7667
KCMF1	5611	7491
KCNAB2	-9357	6982
KPNB1	67	557
KRT1	8174	5752
LAIR1	-2261	9900
LAMP1	1557	8684
LAMP2	9626	9234
LAMTOR1	10275	10468
LAMTOR2	6251	9811
LAMTOR3	9336	8131
LCN2	9492	6870
LGALS3	9840	9259
LILRB2	7666	10116
LILRB3	8925	10163
LPCAT1	-10615	-1283
LRG1	8829	9304
LRRC7	-2647	1172
LTA4H	10110	10291
LTF	9350	4940
LYZ	10158	5170
MAGT1	4037	5258
MAN2B1	6033	6605
MANBA	8844	7868
MAPK1	-1086	9427
MAPK14	10026	9803
MCEMP1	10355	10554
METTL7A	6476	8678
MGAM	9062	9613
MGST1	10318	10658
MIF	-427	-5003
MLEC	-220	4725
MME	-3693	-8367
MMP25	7595	8922
MMP8	5024	9987
MMP9	8967	1371
MNDA	10302	9902
MOSPD2	10095	8658
MPO	10011	5205
MS4A3	8641	-1759
MVP	8914	6884
NAPRT	6733	8768
NBEAL2	4481	7538
NCKAP1L	1901	10162
NCSTN	9915	10361
NDUFC2	7348	9008
NEU1	9609	10026
NFAM1	9877	10409
NFKB1	8527	5403
NHLRC3	4425	7076
NIT2	-5470	-9344
NME2	5550	1269
NPC2	8648	6362
NRAS	8582	7708
OLFM4	4279	7865
OLR1	9142	-629
ORM1	9208	6694
ORM2	1731	-2088
ORMDL3	-10039	-8440
OSCAR	9873	9943
OSTF1	7593	8307
P2RX1	566	10417
PA2G4	5160	-928
PADI2	10200	10268
PAFAH1B2	7578	8153
PDAP1	3713	8107
PDXK	9531	9355
PECAM1	7190	9387
PFKL	-4628	-3901
PGAM1	10347	10422
PGLYRP1	9124	7399
PGM1	2601	6092
PGM2	10212	10292
PGRMC1	6912	7496
PIGR	3970	5820
PKM	10317	10280
PLAC8	8969	10175
PLAU	4112	3352
PLAUR	9724	9965
PLD1	10119	10572
PLEKHO2	6402	8506
PNP	9592	9563
PPBP	5440	6001
PPIA	285	1417
PPIE	-3976	-8580
PRCP	9464	9217
PRDX4	7205	2372
PRDX6	9478	8747
PRKCD	9710	9721
PRTN3	10009	6834
PSAP	8066	8239
PSEN1	7406	9055
PSMA2	9175	6486
PSMA5	6009	-5256
PSMB1	8548	3242
PSMB7	9346	8950
PSMC2	4967	6378
PSMC3	2824	4673
PSMD1	8509	8974
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD6	9864	9375
PSMD7	9212	6772
PTAFR	10084	10562
PTGES2	-4699	-4573
PTPN6	3230	7923
PTPRB	-9309	-1901
PTPRC	-4530	4553
PTPRJ	1010	9383
PTPRN2	7727	4489
PTX3	9712	4622
PYCARD	8846	9930
PYGB	-6473	454
PYGL	10308	10199
QPCT	10273	10185
QSOX1	9888	10475
RAB10	9916	9959
RAB14	8765	8436
RAB18	9744	7495
RAB24	5628	2552
RAB27A	9159	9152
RAB31	10008	10290
RAB37	-10867	-10259
RAB3A	6440	9746
RAB3D	9091	10183
RAB44	6119	-1305
RAB4B	-3971	4641
RAB5B	-279	7773
RAB5C	8923	9415
RAB6A	8383	9332
RAB7A	9941	9609
RAB9B	-6342	1453
RAC1	9345	9946
RAP1A	9691	8186
RAP1B	-3254	7324
RAP2B	-7124	-440
RAP2C	785	5615
RETN	10075	10034
RHOA	9541	9090
RHOF	-10845	-10601
RHOG	8649	8946
RNASE2	10359	10657
RNASE3	10043	8604
RNASET2	5772	5567
ROCK1	5871	8890
S100A11	10016	9498
S100A12	10367	10617
S100A8	10362	10564
S100A9	10316	10598
S100P	8625	9159
SCAMP1	6325	2268
SDCBP	10246	10113
SELL	9795	9352
SERPINA1	10186	10295
SERPINB1	10330	10507
SERPINB10	10233	9723
SERPINB6	4741	9944
SIGLEC14	9432	1567
SIGLEC5	9147	7119
SIGLEC9	9906	10513
SIRPA	10351	10576
SIRPB1	7561	9956
SLC11A1	9804	10582
SLC15A4	-7633	6832
SLC27A2	8033	-6002
SLC2A3	10169	9727
SLC2A5	7318	181
SLC44A2	-3421	2167
SLCO4C1	-9301	4048
SLPI	9574	1116
SNAP23	9581	8746
SNAP29	-5542	9818
SPTAN1	-10045	-9563
SRP14	5097	7759
STBD1	6327	6394
STING1	8496	4759
STK10	-10751	-1875
STK11IP	-4945	7132
STOM	2462	8162
SURF4	6833	7852
SVIP	3352	1164
SYNGR1	-5375	-4808
TARM1	9495	6302
TBC1D10C	-10068	-10544
TCIRG1	253	9871
TCN1	9143	3640
TICAM2	9445	5256
TIMP2	10080	10603
TLR2	10239	9881
TMBIM1	8125	9006
TMC6	-6434	-9567
TMEM179B	5717	-1815
TMEM30A	9426	8525
TMEM63A	-1855	-9668
TNFAIP6	9826	9521
TNFRSF1B	-1892	8266
TOLLIP	8936	8482
TOM1	9316	10512
TRAPPC1	6932	9117
TRPM2	9977	10050
TSPAN14	-3505	8543
TUBB	-6747	-3278
TUBB4B	7592	5692
TXNDC5	5836	-3635
TYROBP	6739	8642
UBR4	-9246	-21
UNC13D	-69	8894
VAMP8	7797	7239
VAPA	9859	9626
VAT1	9646	10524
VCL	913	8321
VCP	7591	6702
VNN1	10163	10414
VPS35L	6316	8792
XRCC5	7806	6087
XRCC6	6022	-236
YPEL5	5177	5140

---

---

Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

metric	value
setSize	27
pMANOVA	2.34e-07
p.adjustMANOVA	1.73e-06
s.dist	0.758
s.low.CRP	-0.463
s.high.CRP	-0.6
p.low.CRP	3.13e-05
p.high.CRP	6.63e-08

Top 20 genes

Gene	low CRP	high CRP
CD247	-10994	-10515
HLA-DPB1	-10605	-10638
HLA-DPA1	-10572	-10652
TRBC1	-10279	-10323
LCK	-9185	-10569
HLA-DRA	-8799	-10557
TRAV19	-8655	-10178
CD3G	-8283	-10568
CD3D	-7327	-10481
TRAV8-4	-7052	-9962
HLA-DQB2	-7036	-9597
HLA-DQA1	-5841	-10469
TRBV12-3	-5797	-9067
CD3E	-4636	-10489
HLA-DRB5	-5253	-8129
TRAC	-3310	-10643
HLA-DRB1	-3832	-8988
TRBV7-9	-3767	-6477
HLA-DQA2	-4322	-3258

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CD247	-10994	-10515
CD3D	-7327	-10481
CD3E	-4636	-10489
CD3G	-8283	-10568
CD4	1506	-6863
CSK	-2015	6501
HLA-DPA1	-10572	-10652
HLA-DPB1	-10605	-10638
HLA-DQA1	-5841	-10469
HLA-DQA2	-4322	-3258
HLA-DQB1	2746	-7642
HLA-DQB2	-7036	-9597
HLA-DRA	-8799	-10557
HLA-DRB1	-3832	-8988
HLA-DRB5	-5253	-8129
LCK	-9185	-10569
PAG1	1967	6079
PTPN22	-7799	6117
PTPRC	-4530	4553
PTPRJ	1010	9383
TRAC	-3310	-10643
TRAV19	-8655	-10178
TRAV29DV5	83	-10423
TRAV8-4	-7052	-9962
TRBC1	-10279	-10323
TRBV12-3	-5797	-9067
TRBV7-9	-3767	-6477

---

---

Dissolution of Fibrin Clot

Dissolution of Fibrin Clot

metric	value
setSize	12
pMANOVA	0.00132
p.adjustMANOVA	0.0045
s.dist	0.756
s.low.CRP	0.479
s.high.CRP	0.585
p.low.CRP	0.00408
p.high.CRP	0.000447

Top 20 genes

Gene	low CRP	high CRP
SERPINB2	10291	10534
SERPINB8	9914	10128
ANXA2	9791	10138
PLAUR	9724	9965
S100A10	7937	9315
SERPINB6	4741	9944
SERPINE1	3011	7764
SERPINE2	2260	8010
PLAU	4112	3352

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ANXA2	9791	10138
PLAT	5536	-2047
PLAU	4112	3352
PLAUR	9724	9965
PLG	299	-2400
S100A10	7937	9315
SERPINB2	10291	10534
SERPINB6	4741	9944
SERPINB8	9914	10128
SERPINE1	3011	7764
SERPINE2	2260	8010
SERPINF2	-10171	140

---

---

GRB2:SOS provides linkage to MAPK signaling for Integrins

GRB2:SOS provides linkage to MAPK signaling for Integrins

metric	value
setSize	12
pMANOVA	0.0017
p.adjustMANOVA	0.00557
s.dist	0.752
s.low.CRP	0.54
s.high.CRP	0.524
p.low.CRP	0.0012
p.high.CRP	0.00167

Top 20 genes

Gene	low CRP	high CRP
GRB2	9960	10389
APBB1IP	10051	8873
ITGA2B	8831	9692
RAP1A	9691	8186
ITGB3	7696	8680
FN1	9912	6648
TLN1	5974	9916
VWF	3995	7559
PTK2	4992	3213

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
APBB1IP	10051	8873
FN1	9912	6648
GRB2	9960	10389
ITGA2B	8831	9692
ITGB3	7696	8680
PTK2	4992	3213
RAP1A	9691	8186
RAP1B	-3254	7324
SOS1	2394	-4661
SRC	-4936	-8846
TLN1	5974	9916
VWF	3995	7559

---

---

Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization

metric	value
setSize	14
pMANOVA	0.000629
p.adjustMANOVA	0.00232
s.dist	0.749
s.low.CRP	0.519
s.high.CRP	0.54
p.low.CRP	0.000778
p.high.CRP	0.000469

Top 20 genes

Gene	low CRP	high CRP
RAB1A	10223	9909
MAPK3	9769	9676
RAB2A	9390	9368
RAB1B	8291	9474
USO1	8607	7741
GORASP1	8524	6879
BLZF1	6821	4413
CCNB2	3046	5291
PLK1	3226	4831

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
BLZF1	6821	4413
CCNB1	3492	-7
CCNB2	3046	5291
CDK1	7292	-2497
GOLGA2	-6652	7914
GORASP1	8524	6879
GORASP2	2049	-1903
MAPK1	-1086	9427
MAPK3	9769	9676
PLK1	3226	4831
RAB1A	10223	9909
RAB1B	8291	9474
RAB2A	9390	9368
USO1	8607	7741

---

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

metric	value
setSize	10
pMANOVA	0.00488
p.adjustMANOVA	0.0144
s.dist	0.743
s.low.CRP	0.471
s.high.CRP	0.574
p.low.CRP	0.00991
p.high.CRP	0.00167

Top 20 genes

Gene	low CRP	high CRP
NCSTN	9915	10361
ADAM10	9652	10284
JAG1	8281	9220
PSEN1	7406	9055
PSENEN	8280	7751
APH1B	5962	8800
YWHAZ	7112	6341
APH1A	3292	4183

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ADAM10	9652	10284
APH1A	3292	4183
APH1B	5962	8800
JAG1	8281	9220
NCSTN	9915	10361
NOTCH4	-10239	2947
PSEN1	7406	9055
PSEN2	-2616	-7755
PSENEN	8280	7751
YWHAZ	7112	6341

---

---

HuR (ELAVL1) binds and stabilizes mRNA

HuR (ELAVL1) binds and stabilizes mRNA

metric	value
setSize	10
pMANOVA	0.0055
p.adjustMANOVA	0.016
s.dist	0.73
s.low.CRP	0.573
s.high.CRP	0.452
p.low.CRP	0.0017
p.high.CRP	0.0132

Top 20 genes

Gene	low CRP	high CRP
PRKCD	9710	9721
TNFSF13	8815	9829
ANP32A	9146	9208
NUP214	8257	8111
XPO1	7772	4672
ENPP2	4361	4777
ELAVL1	1210	4619
PRKCA	2691	1966

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ANP32A	9146	9208
ELAVL1	1210	4619
ENPP2	4361	4777
GPRC5A	7880	-788
NUP214	8257	8111
PRKCA	2691	1966
PRKCD	9710	9721
SET	-1893	-3953
TNFSF13	8815	9829
XPO1	7772	4672

---

---

Signaling by Leptin

Signaling by Leptin

metric	value
setSize	10
pMANOVA	0.00691
p.adjustMANOVA	0.0194
s.dist	0.728
s.low.CRP	0.523
s.high.CRP	0.507
p.low.CRP	0.00421
p.high.CRP	0.00554

Top 20 genes

Gene	low CRP	high CRP
SOCS3	10312	10656
STAT3	9401	8593
STAT5A	8323	7832
LEPR	6442	8474
IRS2	3826	10432
PTPN11	3471	9688
STAT5B	4680	4956
IRS1	1115	1691

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
IRS1	1115	1691
IRS2	3826	10432
JAK2	8894	-2339
LEPR	6442	8474
PTPN11	3471	9688
SH2B1	-3893	-6025
SOCS3	10312	10656
STAT3	9401	8593
STAT5A	8323	7832
STAT5B	4680	4956

---

---

COPI-independent Golgi-to-ER retrograde traffic

COPI-independent Golgi-to-ER retrograde traffic

metric	value
setSize	33
pMANOVA	1.39e-08
p.adjustMANOVA	1.23e-07
s.dist	0.726
s.low.CRP	0.406
s.high.CRP	0.602
p.low.CRP	5.34e-05
p.high.CRP	2.14e-09

Top 20 genes

Gene	low CRP	high CRP
PLA2G4A	10226	10618
DCTN2	9097	10370
DCTN6	9751	9405
CAPZA2	10077	9039
CAPZA1	9332	9316
ACTR10	9447	8995
DYNC1I2	8978	9397
RAB6A	8383	9332
GALNT2	7832	9935
CAPZB	8393	8843
RAB18	9744	7495
PAFAH1B2	7578	8153
GALNT1	7857	7854
DCTN4	5909	10148
DYNC1LI1	8227	7194
RAB3GAP1	9145	6282
DYNLL1	6414	7208
RAB3GAP2	4864	7377
AGPAT3	7444	4388
BICD2	2764	10214

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ACTR10	9447	8995
ACTR1A	1291	7735
AGPAT3	7444	4388
BICD1	-9266	-1245
BICD2	2764	10214
CAPZA1	9332	9316
CAPZA2	10077	9039
CAPZB	8393	8843
DCTN1	-4701	7431
DCTN2	9097	10370
DCTN3	3675	7530
DCTN4	5909	10148
DCTN5	-6881	5731
DCTN6	9751	9405
DYNC1H1	-9811	-4718
DYNC1I1	378	6338
DYNC1I2	8978	9397
DYNC1LI1	8227	7194
DYNC1LI2	909	7271
DYNLL1	6414	7208
DYNLL2	-5827	-2261
GALNT1	7857	7854
GALNT2	7832	9935
PAFAH1B1	491	7762
PAFAH1B2	7578	8153
PAFAH1B3	7890	1430
PLA2G4A	10226	10618
PLA2G6	-10438	-10350
RAB18	9744	7495
RAB3GAP1	9145	6282
RAB3GAP2	4864	7377
RAB6A	8383	9332
RAB6B	3094	7305

---

---

RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate WASPs and WAVEs

metric	value
setSize	35
pMANOVA	1.28e-08
p.adjustMANOVA	1.14e-07
s.dist	0.72
s.low.CRP	0.425
s.high.CRP	0.58
p.low.CRP	1.32e-05
p.high.CRP	2.78e-09

Top 20 genes

Gene	low CRP	high CRP
WASF1	10267	10673
CYFIP1	10019	10571
GRB2	9960	10389
ACTB	10142	9915
ARPC5	9932	9762
ARPC1B	9189	10351
MAPK3	9769	9676
WAS	9521	9854
RAC1	9345	9946
ARPC3	9674	9506
ARPC1A	9171	9991
ACTG1	8859	9583
ACTR2	9004	9240
ACTR3	9818	8294
CDC42	9246	8570
ARPC4	7777	8635
WASF2	6329	9933
ABI1	7076	8607
ARPC2	7187	8262
BTK	5823	9633

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ABI1	7076	8607
ABI2	-8604	-8517
ABL1	-8248	3812
ACTB	10142	9915
ACTG1	8859	9583
ACTR2	9004	9240
ACTR3	9818	8294
ARPC1A	9171	9991
ARPC1B	9189	10351
ARPC2	7187	8262
ARPC3	9674	9506
ARPC4	7777	8635
ARPC5	9932	9762
BAIAP2	-5772	-4014
BRK1	5824	7761
BTK	5823	9633
CDC42	9246	8570
CYFIP1	10019	10571
CYFIP2	-10388	-8406
GRB2	9960	10389
MAPK1	-1086	9427
MAPK3	9769	9676
NCK1	-8084	-8497
NCKAP1	2316	10142
NCKAP1L	1901	10162
NCKIPSD	289	-2712
PTK2	4992	3213
RAC1	9345	9946
WAS	9521	9854
WASF1	10267	10673
WASF2	6329	9933
WASF3	5357	6353
WASL	-3272	1473
WIPF1	-7238	-2901
WIPF2	1332	7562

---

---

RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases

metric	value
setSize	21
pMANOVA	4.4e-05
p.adjustMANOVA	0.000213
s.dist	0.706
s.low.CRP	0.453
s.high.CRP	0.541
p.low.CRP	0.000324
p.high.CRP	1.78e-05

Top 20 genes

Gene	low CRP	high CRP
S100A8	10362	10564
S100A9	10316	10598
NCF2	10167	10265
NCF4	10090	10097
CYBB	10294	9839
MAPK14	10026	9803
MAPK3	9769	9676
PRKCD	9710	9721
RAC1	9345	9946
MAPK11	8895	6888
CYBA	5409	8122
NCF1	7986	3322
PIK3C3	4588	3248
PRKCA	2691	1966

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CYBA	5409	8122
CYBB	10294	9839
MAPK1	-1086	9427
MAPK11	8895	6888
MAPK14	10026	9803
MAPK3	9769	9676
NCF1	7986	3322
NCF2	10167	10265
NCF4	10090	10097
NOXA1	-240	-6607
PIK3C3	4588	3248
PIK3R4	-624	-83
PIN1	-6018	434
PRKCA	2691	1966
PRKCB	-4906	9024
PRKCD	9710	9721
PRKCZ	-10726	-9780
RAC1	9345	9946
RAC2	-1305	4460
S100A8	10362	10564
S100A9	10316	10598

---

---

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

metric	value
setSize	13
pMANOVA	0.000542
p.adjustMANOVA	0.00204
s.dist	0.702
s.low.CRP	0.331
s.high.CRP	0.619
p.low.CRP	0.0386
p.high.CRP	0.00011

Top 20 genes

Gene	low CRP	high CRP
RAC1	9345	9946
CRK	9214	9663
RHOA	9541	9090
PTK6	7972	8367
NRAS	8582	7708
ELMO1	3674	6433
KRAS	4388	5328
DOCK1	2337	9856

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ARHGAP35	-7422	1698
CRK	9214	9663
DOCK1	2337	9856
ELMO1	3674	6433
ELMO2	-6937	7218
HRAS	2906	-3843
KRAS	4388	5328
NRAS	8582	7708
PTK6	7972	8367
PXN	-1154	6730
RAC1	9345	9946
RASA1	-703	7613
RHOA	9541	9090

---

---

Transferrin endocytosis and recycling

Transferrin endocytosis and recycling

metric	value
setSize	26
pMANOVA	6e-06
p.adjustMANOVA	3.41e-05
s.dist	0.701
s.low.CRP	0.481
s.high.CRP	0.51
p.low.CRP	2.15e-05
p.high.CRP	6.73e-06

Top 20 genes

Gene	low CRP	high CRP
ATP6V0A1	10207	10551
ATP6V1A	10093	10441
ATP6V0D1	10069	10341
ATP6V1B2	10130	10122
ATP6V1D	9919	9993
ATP6V1C1	10266	9394
ATP6V0C	9621	9869
ATP6V0B	9087	9653
ATP6V0E1	8986	9188
HFE	10269	7986
ATP6V1E1	9071	8178
ATP6V1H	8628	8476
ATP6V1F	8059	6808
ATP6V1E2	9253	5767
ATP6AP1	4019	10005
ATP6V1G1	7364	3710
TFRC	3905	5758
STEAP3	2363	7339
MCOLN1	1384	8921
TF	2007	3922

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ATP6AP1	4019	10005
ATP6V0A1	10207	10551
ATP6V0A2	-10746	-8412
ATP6V0B	9087	9653
ATP6V0C	9621	9869
ATP6V0D1	10069	10341
ATP6V0E1	8986	9188
ATP6V0E2	-4949	-10370
ATP6V1A	10093	10441
ATP6V1B2	10130	10122
ATP6V1C1	10266	9394
ATP6V1C2	-1408	-231
ATP6V1D	9919	9993
ATP6V1E1	9071	8178
ATP6V1E2	9253	5767
ATP6V1F	8059	6808
ATP6V1G1	7364	3710
ATP6V1G2	-3663	-8648
ATP6V1H	8628	8476
HFE	10269	7986
MCOLN1	1384	8921
STEAP3	2363	7339
TCIRG1	253	9871
TF	2007	3922
TFR2	-9093	-7487
TFRC	3905	5758

---

---

Cargo concentration in the ER

Cargo concentration in the ER

metric	value
setSize	30
pMANOVA	5.35e-07
p.adjustMANOVA	3.74e-06
s.dist	0.699
s.low.CRP	0.425
s.high.CRP	0.555
p.low.CRP	5.63e-05
p.high.CRP	1.44e-07

Top 20 genes

Gene	low CRP	high CRP
F5	10339	10599
SERPINA1	10186	10295
CTSZ	9796	10451
SEC24D	8466	9932
SAR1B	9412	8914
CNIH1	9266	8825
SEC24A	8608	8866
MCFD2	7974	9249
F8	7904	8494
SEC23A	8250	8136
LMAN2L	7489	7830
TGFA	5895	9650
LMAN2	6893	7688
STX5	6777	7536
TMED2	6691	7410
SEC22B	9017	4952
MIA2	6400	5836
PREB	4312	7535
CD59	6386	4199
TMED10	4984	4383

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
AREG	-5505	9162
CD59	6386	4199
CNIH1	9266	8825
CNIH2	2506	2667
CNIH3	-9428	-8506
COL7A1	-442	8394
CTSC	-3910	5638
CTSZ	9796	10451
F5	10339	10599
F8	7904	8494
GOSR2	-1757	3596
LMAN1	-2101	-9736
LMAN2	6893	7688
LMAN2L	7489	7830
MCFD2	7974	9249
MIA2	6400	5836
MIA3	40	-2504
PREB	4312	7535
SAR1B	9412	8914
SEC22B	9017	4952
SEC23A	8250	8136
SEC24A	8608	8866
SEC24B	280	5708
SEC24C	-8540	1964
SEC24D	8466	9932
SERPINA1	10186	10295
STX5	6777	7536
TGFA	5895	9650
TMED10	4984	4383
TMED2	6691	7410

---

---

Budding and maturation of HIV virion

Budding and maturation of HIV virion

metric	value
setSize	26
pMANOVA	7.33e-06
p.adjustMANOVA	4.06e-05
s.dist	0.696
s.low.CRP	0.48
s.high.CRP	0.503
p.low.CRP	2.23e-05
p.high.CRP	8.9e-06

Top 20 genes

Gene	low CRP	high CRP
CHMP4B	9666	9765
CHMP2A	9715	9488
UBAP1	9245	9187
VPS37C	9329	8849
CHMP3	8652	9021
PDCD6IP	8622	9034
TSG101	9865	7776
MVB12A	7215	9463
VTA1	8205	7811
VPS37A	8256	7697
CHMP2B	8303	5566
CHMP5	7394	5917
VPS4B	6755	6176
NEDD4L	4410	9142
CHMP4A	6441	5030
UBB	7788	3835
VPS28	5467	4829
MVB12B	2169	4830
UBC	2562	2822
VPS4A	330	3807

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CHMP2A	9715	9488
CHMP2B	8303	5566
CHMP3	8652	9021
CHMP4A	6441	5030
CHMP4B	9666	9765
CHMP5	7394	5917
CHMP6	-3413	6801
CHMP7	-3563	-7134
MVB12A	7215	9463
MVB12B	2169	4830
NEDD4L	4410	9142
PDCD6IP	8622	9034
PPIA	285	1417
RPS27A	-1868	-5386
TSG101	9865	7776
UBA52	2067	260
UBAP1	9245	9187
UBB	7788	3835
UBC	2562	2822
VPS28	5467	4829
VPS37A	8256	7697
VPS37B	-9060	3262
VPS37C	9329	8849
VPS4A	330	3807
VPS4B	6755	6176
VTA1	8205	7811

---

---

Endosomal Sorting Complex Required For Transport (ESCRT)

Endosomal Sorting Complex Required For Transport (ESCRT)

metric	value
setSize	29
pMANOVA	2.53e-06
p.adjustMANOVA	1.56e-05
s.dist	0.688
s.low.CRP	0.489
s.high.CRP	0.484
p.low.CRP	5.07e-06
p.high.CRP	6.42e-06

Top 20 genes

Gene	low CRP	high CRP
CHMP4B	9666	9765
CHMP2A	9715	9488
UBAP1	9245	9187
VPS37C	9329	8849
VPS25	8588	9314
CHMP3	8652	9021
TSG101	9865	7776
MVB12A	7215	9463
VTA1	8205	7811
VPS37A	8256	7697
STAM2	8313	7133
SNF8	6092	7999
CHMP2B	8303	5566
CHMP5	7394	5917
VPS4B	6755	6176
CHMP4A	6441	5030
UBB	7788	3835
VPS28	5467	4829
MVB12B	2169	4830
UBC	2562	2822

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CHMP2A	9715	9488
CHMP2B	8303	5566
CHMP3	8652	9021
CHMP4A	6441	5030
CHMP4B	9666	9765
CHMP5	7394	5917
CHMP6	-3413	6801
CHMP7	-3563	-7134
HGS	813	5448
MVB12A	7215	9463
MVB12B	2169	4830
RPS27A	-1868	-5386
SNF8	6092	7999
STAM	2880	1495
STAM2	8313	7133
TSG101	9865	7776
UBA52	2067	260
UBAP1	9245	9187
UBB	7788	3835
UBC	2562	2822
VPS25	8588	9314
VPS28	5467	4829
VPS36	3782	-1712
VPS37A	8256	7697
VPS37B	-9060	3262
VPS37C	9329	8849
VPS4A	330	3807
VPS4B	6755	6176
VTA1	8205	7811

---

---

Cross-presentation of soluble exogenous antigens (endosomes)

Cross-presentation of soluble exogenous antigens (endosomes)

metric	value
setSize	47
pMANOVA	1.46e-10
p.adjustMANOVA	2.23e-09
s.dist	0.688
s.low.CRP	0.562
s.high.CRP	0.397
p.low.CRP	2.57e-11
p.high.CRP	2.46e-06

Top 20 genes

Gene	low CRP	high CRP
FCGR1A	10365	10249
FCGR1B	10361	9771
PSMD6	9864	9375
PSMB7	9346	8950
PSMA1	9165	8953
PSME3	9544	8452
PSMD12	9648	8351
PSMD4	8627	9334
PSMD11	8697	9183
PSMC6	9832	7978
PSMB5	8225	9508
PSMD1	8509	8974
PSMB3	8817	8326
PSMD9	7407	8869
PSMA6	9365	6915
PSMB6	6959	8991
PSMD7	9212	6772
PSMC1	7220	8544
PSMA2	9175	6486
PSMD2	7347	8049

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
FCGR1A	10365	10249
FCGR1B	10361	9771
MRC1	-2922	4812
MRC2	1251	-3015
PSMA1	9165	8953
PSMA2	9175	6486
PSMA3	8811	-3545
PSMA4	8595	258
PSMA5	6009	-5256
PSMA6	9365	6915
PSMA7	6006	7700
PSMB1	8548	3242
PSMB10	-972	-8733
PSMB2	8065	5797
PSMB3	8817	8326
PSMB4	4018	3039
PSMB5	8225	9508
PSMB6	6959	8991
PSMB7	9346	8950
PSMB8	5148	-5793
PSMB9	-5133	-10716
PSMC1	7220	8544
PSMC2	4967	6378
PSMC3	2824	4673
PSMC4	-9365	-3210
PSMC5	2913	2050
PSMC6	9832	7978
PSMD1	8509	8974
PSMD10	6347	2957
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD4	8627	9334
PSMD5	1520	8328
PSMD6	9864	9375
PSMD7	9212	6772
PSMD8	6905	6585
PSMD9	7407	8869
PSME1	-1137	-9489
PSME2	3614	-10267
PSME3	9544	8452
PSME4	-8419	-464
PSMF1	7685	5740
SEM1	5210	6938

---

---

The NLRP3 inflammasome

The NLRP3 inflammasome

metric	value
setSize	15
pMANOVA	0.000759
p.adjustMANOVA	0.00274
s.dist	0.687
s.low.CRP	0.56
s.high.CRP	0.398
p.low.CRP	0.000175
p.high.CRP	0.00762

Top 20 genes

Gene	low CRP	high CRP
APP	10085	9961
NLRP3	9713	9646
PYCARD	8846	9930
MEFV	9121	9560
TXN	9660	8103
PANX1	6838	8716
NFKB1	8527	5403
CASP1	9611	2857
SUGT1	4885	5013
P2RX7	7506	2020
PSTPIP1	635	9877

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
APP	10085	9961
CASP1	9611	2857
HSP90AB1	4616	-5342
MEFV	9121	9560
NFKB1	8527	5403
NFKB2	5450	-6553
NLRP3	9713	9646
P2RX7	7506	2020
PANX1	6838	8716
PSTPIP1	635	9877
PYCARD	8846	9930
RELA	-2847	-1359
SUGT1	4885	5013
TXN	9660	8103
TXNIP	-7875	-4331

---

---

Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

metric	value
setSize	49
pMANOVA	6.29e-11
p.adjustMANOVA	1.09e-09
s.dist	0.683
s.low.CRP	0.562
s.high.CRP	0.387
p.low.CRP	9.77e-12
p.high.CRP	2.7e-06

Top 20 genes

Gene	low CRP	high CRP
OAZ1	9594	10002
OAZ2	9736	9701
PSMD6	9864	9375
PSMB7	9346	8950
PSMA1	9165	8953
PSME3	9544	8452
PSMD12	9648	8351
PSMD4	8627	9334
PSMD11	8697	9183
PSMC6	9832	7978
PSMB5	8225	9508
PSMD1	8509	8974
PSMB3	8817	8326
PSMD9	7407	8869
PSMA6	9365	6915
PSMB6	6959	8991
PSMD7	9212	6772
PSMC1	7220	8544
PSMA2	9175	6486
PSMD2	7347	8049

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
AZIN1	6823	8066
NQO1	2455	-2338
OAZ1	9594	10002
OAZ2	9736	9701
OAZ3	1748	-2794
ODC1	14	2523
PSMA1	9165	8953
PSMA2	9175	6486
PSMA3	8811	-3545
PSMA4	8595	258
PSMA5	6009	-5256
PSMA6	9365	6915
PSMA7	6006	7700
PSMB1	8548	3242
PSMB10	-972	-8733
PSMB2	8065	5797
PSMB3	8817	8326
PSMB4	4018	3039
PSMB5	8225	9508
PSMB6	6959	8991
PSMB7	9346	8950
PSMB8	5148	-5793
PSMB9	-5133	-10716
PSMC1	7220	8544
PSMC2	4967	6378
PSMC3	2824	4673
PSMC4	-9365	-3210
PSMC5	2913	2050
PSMC6	9832	7978
PSMD1	8509	8974
PSMD10	6347	2957
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD4	8627	9334
PSMD5	1520	8328
PSMD6	9864	9375
PSMD7	9212	6772
PSMD8	6905	6585
PSMD9	7407	8869
PSME1	-1137	-9489
PSME2	3614	-10267
PSME3	9544	8452
PSME4	-8419	-464
PSMF1	7685	5740
SEM1	5210	6938

---

---

Formation of ATP by chemiosmotic coupling

Formation of ATP by chemiosmotic coupling

metric	value
setSize	18
pMANOVA	0.000396
p.adjustMANOVA	0.00152
s.dist	0.68
s.low.CRP	0.466
s.high.CRP	0.495
p.low.CRP	0.000613
p.high.CRP	0.000276

Top 20 genes

Gene	low CRP	high CRP
ATP5PB	9493	9015
ATP5F1C	9580	8671
ATP5PD	9734	8460
ATP5F1A	9557	6994
ATP5PF	7570	8666
ATP5MF	7383	8461
ATP5MG	8134	7589
ATP5F1B	8684	6919
ATP5PO	9184	6042
ATP5MC3	7250	7383
ATP5F1E	6027	6878
ATP5MC2	1987	2992
ATP5F1D	474	359

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ATP5F1A	9557	6994
ATP5F1B	8684	6919
ATP5F1C	9580	8671
ATP5F1D	474	359
ATP5F1E	6027	6878
ATP5MC1	5471	-6148
ATP5MC2	1987	2992
ATP5MC3	7250	7383
ATP5ME	-322	5177
ATP5MF	7383	8461
ATP5MG	8134	7589
ATP5PB	9493	9015
ATP5PD	9734	8460
ATP5PF	7570	8666
ATP5PO	9184	6042
DMAC2L	-3270	-3208
MT-ATP6	-5000	3338
MT-ATP8	-8176	7306

---

---

EPHB-mediated forward signaling

EPHB-mediated forward signaling

metric	value
setSize	32
pMANOVA	1e-06
p.adjustMANOVA	6.7e-06
s.dist	0.678
s.low.CRP	0.493
s.high.CRP	0.465
p.low.CRP	1.4e-06
p.high.CRP	5.27e-06

Top 20 genes

Gene	low CRP	high CRP
ITSN1	9926	10430
ACTB	10142	9915
ARPC5	9932	9762
ARPC1B	9189	10351
RAC1	9345	9946
ARPC3	9674	9506
ARPC1A	9171	9991
CFL1	9368	9341
RHOA	9541	9090
ACTG1	8859	9583
ACTR2	9004	9240
ACTR3	9818	8294
CDC42	9246	8570
PAK1	10129	7653
LYN	8483	8583
LIMK2	9807	6997
ARPC4	7777	8635
ARPC2	7187	8262
ROCK1	5871	8890
SDC2	6034	5778

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ACTB	10142	9915
ACTG1	8859	9583
ACTR2	9004	9240
ACTR3	9818	8294
ARHGEF28	-9412	-8558
ARPC1A	9171	9991
ARPC1B	9189	10351
ARPC2	7187	8262
ARPC3	9674	9506
ARPC4	7777	8635
ARPC5	9932	9762
CDC42	9246	8570
CFL1	9368	9341
FYN	-10683	-7016
HRAS	2906	-3843
ITSN1	9926	10430
KALRN	1792	-5605
LIMK1	2972	6500
LIMK2	9807	6997
LYN	8483	8583
PAK1	10129	7653
PTK2	4992	3213
RAC1	9345	9946
RASA1	-703	7613
RHOA	9541	9090
ROCK1	5871	8890
ROCK2	2896	8362
SDC2	6034	5778
SRC	-4936	-8846
TIAM1	3669	-4480
WASL	-3272	1473
YES1	-10892	-9337

---

---

Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade

metric	value
setSize	23
pMANOVA	6.14e-05
p.adjustMANOVA	0.000285
s.dist	0.67
s.low.CRP	0.484
s.high.CRP	0.464
p.low.CRP	5.95e-05
p.high.CRP	0.000118

Top 20 genes

Gene	low CRP	high CRP
CD36	10363	10493
CD14	10063	10306
TLR2	10239	9881
TLR5	9706	9984
TLR4	9286	10255
TLR1	10059	9241
LY96	9677	9581
CHUK	9608	9191
TLR6	9187	9277
MYD88	8926	8524
BTK	5823	9633
NFKBIA	8114	5809
NFKB1	8527	5403
TICAM1	6577	5314
UNC93B1	42	5485

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
BTK	5823	9633
CD14	10063	10306
CD36	10363	10493
CHUK	9608	9191
IKBKB	-6356	-1160
IKBKG	-595	7203
LY96	9677	9581
MYD88	8926	8524
NFKB1	8527	5403
NFKB2	5450	-6553
NFKBIA	8114	5809
RELA	-2847	-1359
TICAM1	6577	5314
TIRAP	-8	6185
TLR1	10059	9241
TLR10	-4242	-4361
TLR2	10239	9881
TLR3	-9392	-9897
TLR4	9286	10255
TLR5	9706	9984
TLR6	9187	9277
TRAF3	3014	-4910
UNC93B1	42	5485

---

---

Diseases of Immune System

Diseases of Immune System

metric	value
setSize	23
pMANOVA	6.14e-05
p.adjustMANOVA	0.000285
s.dist	0.67
s.low.CRP	0.484
s.high.CRP	0.464
p.low.CRP	5.95e-05
p.high.CRP	0.000118

Top 20 genes

Gene	low CRP	high CRP
CD36	10363	10493
CD14	10063	10306
TLR2	10239	9881
TLR5	9706	9984
TLR4	9286	10255
TLR1	10059	9241
LY96	9677	9581
CHUK	9608	9191
TLR6	9187	9277
MYD88	8926	8524
BTK	5823	9633
NFKBIA	8114	5809
NFKB1	8527	5403
TICAM1	6577	5314
UNC93B1	42	5485

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
BTK	5823	9633
CD14	10063	10306
CD36	10363	10493
CHUK	9608	9191
IKBKB	-6356	-1160
IKBKG	-595	7203
LY96	9677	9581
MYD88	8926	8524
NFKB1	8527	5403
NFKB2	5450	-6553
NFKBIA	8114	5809
RELA	-2847	-1359
TICAM1	6577	5314
TIRAP	-8	6185
TLR1	10059	9241
TLR10	-4242	-4361
TLR2	10239	9881
TLR3	-9392	-9897
TLR4	9286	10255
TLR5	9706	9984
TLR6	9187	9277
TRAF3	3014	-4910
UNC93B1	42	5485

---

---

MET activates RAP1 and RAC1

MET activates RAP1 and RAC1

metric	value
setSize	10
pMANOVA	0.00688
p.adjustMANOVA	0.0194
s.dist	0.668
s.low.CRP	0.338
s.high.CRP	0.576
p.low.CRP	0.0644
p.high.CRP	0.0016

Top 20 genes

Gene	low CRP	high CRP
GRB2	9960	10389
RAC1	9345	9946
HGF	8952	9949
CRK	9214	9663
RAP1A	9691	8186
GAB1	3626	8241

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CRK	9214	9663
CRKL	-1879	4224
DOCK7	-2076	-2321
GAB1	3626	8241
GRB2	9960	10389
HGF	8952	9949
RAC1	9345	9946
RAP1A	9691	8186
RAP1B	-3254	7324
RAPGEF1	-10785	-4187

---

---

Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD

Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD

metric	value
setSize	53
pMANOVA	3.67e-11
p.adjustMANOVA	6.67e-10
s.dist	0.668
s.low.CRP	0.545
s.high.CRP	0.386
p.low.CRP	6.52e-12
p.high.CRP	1.17e-06

Top 20 genes

Gene	low CRP	high CRP
OS9	9572	10053
PSMD6	9864	9375
PSMB7	9346	8950
PSMA1	9165	8953
PSME3	9544	8452
PSMD12	9648	8351
PSMD4	8627	9334
PSMD11	8697	9183
PSMC6	9832	7978
PSMB5	8225	9508
PSMD1	8509	8974
PSMB3	8817	8326
PSMD9	7407	8869
PSMA6	9365	6915
PSMB6	6959	8991
PSMD7	9212	6772
PSMC1	7220	8544
PSMA2	9175	6486
PSMD2	7347	8049
SEL1L	6263	8390

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
DERL2	5626	4860
ERLEC1	3753	5744
OS9	9572	10053
PSMA1	9165	8953
PSMA2	9175	6486
PSMA3	8811	-3545
PSMA4	8595	258
PSMA5	6009	-5256
PSMA6	9365	6915
PSMA7	6006	7700
PSMB1	8548	3242
PSMB10	-972	-8733
PSMB2	8065	5797
PSMB3	8817	8326
PSMB4	4018	3039
PSMB5	8225	9508
PSMB6	6959	8991
PSMB7	9346	8950
PSMB8	5148	-5793
PSMB9	-5133	-10716
PSMC1	7220	8544
PSMC2	4967	6378
PSMC3	2824	4673
PSMC4	-9365	-3210
PSMC5	2913	2050
PSMC6	9832	7978
PSMD1	8509	8974
PSMD10	6347	2957
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD4	8627	9334
PSMD5	1520	8328
PSMD6	9864	9375
PSMD7	9212	6772
PSMD8	6905	6585
PSMD9	7407	8869
PSME1	-1137	-9489
PSME2	3614	-10267
PSME3	9544	8452
PSME4	-8419	-464
PSMF1	7685	5740
RPS27A	-1868	-5386
SEL1L	6263	8390
SEM1	5210	6938
SYVN1	25	3387
UBA52	2067	260
UBB	7788	3835
UBC	2562	2822
VCP	7591	6702

---

---

Regulation of activated PAK-2p34 by proteasome mediated degradation

Regulation of activated PAK-2p34 by proteasome mediated degradation

metric	value
setSize	48
pMANOVA	2.6e-10
p.adjustMANOVA	3.62e-09
s.dist	0.663
s.low.CRP	0.552
s.high.CRP	0.367
p.low.CRP	3.56e-11
p.high.CRP	1.11e-05

Top 20 genes

Gene	low CRP	high CRP
PSMD6	9864	9375
PSMB7	9346	8950
PSMA1	9165	8953
PAK2	9098	8874
PSME3	9544	8452
PSMD12	9648	8351
PSMD4	8627	9334
PSMD11	8697	9183
PSMC6	9832	7978
PSMB5	8225	9508
PSMD1	8509	8974
PSMB3	8817	8326
PSMD9	7407	8869
PSMA6	9365	6915
PSMB6	6959	8991
PSMD7	9212	6772
PSMC1	7220	8544
PSMA2	9175	6486
PSMD2	7347	8049
PSMD13	7185	6511

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
PAK2	9098	8874
PSMA1	9165	8953
PSMA2	9175	6486
PSMA3	8811	-3545
PSMA4	8595	258
PSMA5	6009	-5256
PSMA6	9365	6915
PSMA7	6006	7700
PSMB1	8548	3242
PSMB10	-972	-8733
PSMB2	8065	5797
PSMB3	8817	8326
PSMB4	4018	3039
PSMB5	8225	9508
PSMB6	6959	8991
PSMB7	9346	8950
PSMB8	5148	-5793
PSMB9	-5133	-10716
PSMC1	7220	8544
PSMC2	4967	6378
PSMC3	2824	4673
PSMC4	-9365	-3210
PSMC5	2913	2050
PSMC6	9832	7978
PSMD1	8509	8974
PSMD10	6347	2957
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD4	8627	9334
PSMD5	1520	8328
PSMD6	9864	9375
PSMD7	9212	6772
PSMD8	6905	6585
PSMD9	7407	8869
PSME1	-1137	-9489
PSME2	3614	-10267
PSME3	9544	8452
PSME4	-8419	-464
PSMF1	7685	5740
RPS27A	-1868	-5386
SEM1	5210	6938
UBA52	2067	260
UBB	7788	3835
UBC	2562	2822

---

---

Platelet sensitization by LDL

Platelet sensitization by LDL

metric	value
setSize	16
pMANOVA	0.000303
p.adjustMANOVA	0.00119
s.dist	0.662
s.low.CRP	0.319
s.high.CRP	0.58
p.low.CRP	0.0269
p.high.CRP	5.85e-05

Top 20 genes

Gene	low CRP	high CRP
PLA2G4A	10226	10618
MAPK14	10026	9803
PPP2CA	9766	8577
PPP2CB	9136	9093
FGR	7776	10127
PECAM1	7190	9387
PTPN11	3471	9688
PPP2R5B	4569	7252
PTPN6	3230	7923
PPP2R1A	1997	5379
PPP2R1B	3691	1706
PPP2R5E	522	2302

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
FGR	7776	10127
LRP8	-3317	8175
MAPK14	10026	9803
PECAM1	7190	9387
PLA2G4A	10226	10618
PPP2CA	9766	8577
PPP2CB	9136	9093
PPP2R1A	1997	5379
PPP2R1B	3691	1706
PPP2R5A	-3440	4169
PPP2R5B	4569	7252
PPP2R5C	-9892	-8496
PPP2R5D	-5620	3209
PPP2R5E	522	2302
PTPN11	3471	9688
PTPN6	3230	7923

---

---

IRAK1 recruits IKK complex

IRAK1 recruits IKK complex

metric	value
setSize	10
pMANOVA	0.0085
p.adjustMANOVA	0.0234
s.dist	0.659
s.low.CRP	0.34
s.high.CRP	0.564
p.low.CRP	0.0625
p.high.CRP	0.00202

Top 20 genes

Gene	low CRP	high CRP
CHUK	9608	9191
PELI2	7349	9515
UBE2V1	8249	8108
PELI1	8918	5667
UBE2N	7813	4195
IRAK1	2858	6473

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CHUK	9608	9191
IKBKB	-6356	-1160
IKBKG	-595	7203
IRAK1	2858	6473
PELI1	8918	5667
PELI2	7349	9515
PELI3	-320	9317
TRAF6	-4471	1582
UBE2N	7813	4195
UBE2V1	8249	8108

---

---

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

metric	value
setSize	10
pMANOVA	0.0085
p.adjustMANOVA	0.0234
s.dist	0.659
s.low.CRP	0.34
s.high.CRP	0.564
p.low.CRP	0.0625
p.high.CRP	0.00202

Top 20 genes

Gene	low CRP	high CRP
CHUK	9608	9191
PELI2	7349	9515
UBE2V1	8249	8108
PELI1	8918	5667
UBE2N	7813	4195
IRAK1	2858	6473

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
CHUK	9608	9191
IKBKB	-6356	-1160
IKBKG	-595	7203
IRAK1	2858	6473
PELI1	8918	5667
PELI2	7349	9515
PELI3	-320	9317
TRAF6	-4471	1582
UBE2N	7813	4195
UBE2V1	8249	8108

---

---

Pentose phosphate pathway

Pentose phosphate pathway

metric	value
setSize	13
pMANOVA	0.00513
p.adjustMANOVA	0.015
s.dist	0.655
s.low.CRP	0.438
s.high.CRP	0.487
p.low.CRP	0.00622
p.high.CRP	0.00238

Top 20 genes

Gene	low CRP	high CRP
PGD	10324	10568
TALDO1	10319	10395
PGM2	10212	10292
TKT	9929	10560
G6PD	9299	10309
DERA	9456	9825
PRPS2	9598	3319
PGLS	3944	5885

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
DERA	9456	9825
G6PD	9299	10309
PGD	10324	10568
PGLS	3944	5885
PGM2	10212	10292
PRPS1	-9525	-10253
PRPS2	9598	3319
RBKS	-7371	326
RPE	-444	8383
RPIA	5489	-714
SHPK	-4639	-1540
TALDO1	10319	10395
TKT	9929	10560

---

---

Regulation of Apoptosis

Regulation of Apoptosis

metric	value
setSize	51
pMANOVA	9.12e-11
p.adjustMANOVA	1.5e-09
s.dist	0.653
s.low.CRP	0.549
s.high.CRP	0.353
p.low.CRP	1.13e-11
p.high.CRP	1.26e-05

Top 20 genes

Gene	low CRP	high CRP
PSMD6	9864	9375
PSMB7	9346	8950
PSMA1	9165	8953
PAK2	9098	8874
PSME3	9544	8452
PSMD12	9648	8351
PSMD4	8627	9334
PSMD11	8697	9183
PSMC6	9832	7978
PSMB5	8225	9508
PSMD1	8509	8974
PSMB3	8817	8326
PSMD9	7407	8869
PSMA6	9365	6915
PSMB6	6959	8991
PSMD7	9212	6772
PSMC1	7220	8544
PSMA2	9175	6486
PSMD2	7347	8049
PSMD13	7185	6511

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
ARHGAP10	1783	-6828
OMA1	8705	4009
OPA1	4563	7289
PAK2	9098	8874
PSMA1	9165	8953
PSMA2	9175	6486
PSMA3	8811	-3545
PSMA4	8595	258
PSMA5	6009	-5256
PSMA6	9365	6915
PSMA7	6006	7700
PSMB1	8548	3242
PSMB10	-972	-8733
PSMB2	8065	5797
PSMB3	8817	8326
PSMB4	4018	3039
PSMB5	8225	9508
PSMB6	6959	8991
PSMB7	9346	8950
PSMB8	5148	-5793
PSMB9	-5133	-10716
PSMC1	7220	8544
PSMC2	4967	6378
PSMC3	2824	4673
PSMC4	-9365	-3210
PSMC5	2913	2050
PSMC6	9832	7978
PSMD1	8509	8974
PSMD10	6347	2957
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD4	8627	9334
PSMD5	1520	8328
PSMD6	9864	9375
PSMD7	9212	6772
PSMD8	6905	6585
PSMD9	7407	8869
PSME1	-1137	-9489
PSME2	3614	-10267
PSME3	9544	8452
PSME4	-8419	-464
PSMF1	7685	5740
RPS27A	-1868	-5386
SEM1	5210	6938
UBA52	2067	260
UBB	7788	3835
UBC	2562	2822

---

---

AUF1 (hnRNP D0) binds and destabilizes mRNA

AUF1 (hnRNP D0) binds and destabilizes mRNA

metric	value
setSize	53
pMANOVA	1.33e-10
p.adjustMANOVA	2.07e-09
s.dist	0.641
s.low.CRP	0.533
s.high.CRP	0.356
p.low.CRP	1.85e-11
p.high.CRP	7.13e-06

Top 20 genes

Gene	low CRP	high CRP
PSMD6	9864	9375
PSMB7	9346	8950
PSMA1	9165	8953
PSME3	9544	8452
PSMD12	9648	8351
PSMD4	8627	9334
PSMD11	8697	9183
PSMC6	9832	7978
PSMB5	8225	9508
PSMD1	8509	8974
PSMB3	8817	8326
PSMD9	7407	8869
PSMA6	9365	6915
PSMB6	6959	8991
PSMD7	9212	6772
PSMC1	7220	8544
HSPA1A	8518	7125
PSMA2	9175	6486
PSMD2	7347	8049
EIF4G1	5724	10120

Click HERE to show all gene set members

All member genes

	low CRP	high CRP
EIF4G1	5724	10120
HNRNPD	6571	7988
HSPA1A	8518	7125
HSPA8	-4222	-8984
HSPB1	2287	921
PABPC1	7203	5354
PSMA1	9165	8953
PSMA2	9175	6486
PSMA3	8811	-3545
PSMA4	8595	258
PSMA5	6009	-5256
PSMA6	9365	6915
PSMA7	6006	7700
PSMB1	8548	3242
PSMB10	-972	-8733
PSMB2	8065	5797
PSMB3	8817	8326
PSMB4	4018	3039
PSMB5	8225	9508
PSMB6	6959	8991
PSMB7	9346	8950
PSMB8	5148	-5793
PSMB9	-5133	-10716
PSMC1	7220	8544
PSMC2	4967	6378
PSMC3	2824	4673
PSMC4	-9365	-3210
PSMC5	2913	2050
PSMC6	9832	7978
PSMD1	8509	8974
PSMD10	6347	2957
PSMD11	8697	9183
PSMD12	9648	8351
PSMD13	7185	6511
PSMD14	7985	5632
PSMD2	7347	8049
PSMD3	3057	6067
PSMD4	8627	9334
PSMD5	1520	8328
PSMD6	9864	9375
PSMD7	9212	6772
PSMD8	6905	6585
PSMD9	7407	8869
PSME1	-1137	-9489
PSME2	3614	-10267
PSME3	9544	8452
PSME4	-8419	-464
PSMF1	7685	5740
RPS27A	-1868	-5386
SEM1	5210	6938
UBA52	2067	260
UBB	7788	3835
UBC	2562	2822

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0               GGally_2.1.1               
##  [3] beeswarm_0.3.1              gtools_3.8.2               
##  [5] echarts4r_0.4.0             topconfects_1.6.0          
##  [7] limma_3.46.0                eulerr_6.1.0               
##  [9] mitch_1.2.2                 MASS_7.3-53.1              
## [11] fgsea_1.16.0                gplots_3.1.1               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.58.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] reshape2_1.4.4              forcats_0.5.1              
## [25] stringr_1.4.0               dplyr_1.0.5                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.3                 tibble_3.1.0               
## [31] ggplot2_3.3.3               tidyverse_1.3.0            
## [33] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_2.0.2       
##   [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.13       
##   [7] farver_2.1.0           bit64_4.0.5            AnnotationDbi_1.52.0  
##  [10] fansi_0.4.2            lubridate_1.7.10       xml2_1.3.2            
##  [13] splines_4.0.3          cachem_1.0.4           geneplotter_1.68.0    
##  [16] knitr_1.31             polyclip_1.10-0        jsonlite_1.7.2        
##  [19] broom_0.7.5            annotate_1.68.0        dbplyr_2.1.0          
##  [22] shiny_1.6.0            compiler_4.0.3         httr_1.4.2            
##  [25] backports_1.2.1        assertthat_0.2.1       Matrix_1.3-2          
##  [28] fastmap_1.1.0          cli_2.3.1              later_1.1.0.1         
##  [31] htmltools_0.5.1.1      tools_4.0.3            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
##  [37] Rcpp_1.0.6             cellranger_1.1.0       jquerylib_0.1.3       
##  [40] vctrs_0.3.6            polylabelr_0.2.0       xfun_0.22             
##  [43] ps_1.6.0               testthat_3.0.2         rvest_1.0.0           
##  [46] mime_0.10              lifecycle_1.0.0        XML_3.99-0.6          
##  [49] zlibbioc_1.36.0        scales_1.1.1           promises_1.2.0.1      
##  [52] hms_1.0.0              RColorBrewer_1.1-2     yaml_2.2.1            
##  [55] memoise_2.0.0          gridExtra_2.3          sass_0.3.1            
##  [58] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.4         
##  [61] highr_0.8              genefilter_1.72.0      desc_1.3.0            
##  [64] caTools_1.18.1         BiocParallel_1.24.1    rlang_0.4.10          
##  [67] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
##  [70] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.3     
##  [73] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
##  [76] magrittr_2.0.1         R6_2.5.0               generics_0.1.0        
##  [79] DelayedArray_0.16.0    DBI_1.1.1              pillar_1.5.1          
##  [82] haven_2.3.1            withr_2.4.1            survival_3.2-10       
##  [85] RCurl_1.98-1.3         modelr_0.1.8           crayon_1.4.1          
##  [88] KernSmooth_2.23-18     utf8_1.2.1             rmarkdown_2.7         
##  [91] locfit_1.5-9.4         grid_4.0.3             readxl_1.3.1          
##  [94] data.table_1.14.0      blob_1.2.1             reprex_1.0.0          
##  [97] digest_0.6.27          xtable_1.8-4           httpuv_1.5.5          
## [100] munsell_0.5.0          bslib_0.2.4

END of report