date generated: 2021-04-20

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             low CRP   high CRP
## A1BG      1.3448650  1.7900749
## A1BG-AS1  0.6121583  0.2690665
## A1CF      0.3948857  0.1941578
## A2M      -1.2249521 -2.9774271
## A2M-AS1  -1.3083997 -2.2977591
## A2ML1    -0.7528612 -0.4068597

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 21404
duplicated_genes_present 0
num_profile_genes_in_sets 8378
num_profile_genes_not_in_sets 13026
profile_pearson_correl 0.64689
profile_spearman_correl 0.59772

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1045
num_genesets_included 1363

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 586

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.low.CRP s.high.CRP p.low.CRP p.high.CRP
Neutrophil degranulation 456 0.00e+00 0.00e+00 0.760 0.5360 0.5390 3.01e-86 2.42e-87
Innate Immune System 963 8.82e-86 6.01e-83 0.470 0.3570 0.3060 4.15e-79 2.68e-58
Immune System 1885 3.55e-42 1.61e-39 0.241 0.1820 0.1580 3.38e-39 8.29e-30
Membrane Trafficking 555 5.19e-40 1.77e-37 0.387 0.1970 0.3330 2.01e-15 3.07e-41
Metabolism 1758 1.93e-34 5.26e-32 0.224 0.1700 0.1450 1.72e-32 4.24e-24
Metabolism of proteins 1706 2.40e-31 5.44e-29 0.216 0.1640 0.1410 1.35e-29 3.77e-22
Scavenging of heme from plasma 70 3.83e-27 7.46e-25 0.513 0.1920 -0.4760 5.38e-03 5.82e-12
Vesicle-mediated transport 644 5.08e-27 8.66e-25 0.316 0.2000 0.2450 4.78e-18 2.49e-26
Classical antibody-mediated complement activation 68 3.04e-23 4.60e-21 0.517 0.0986 -0.5070 1.60e-01 4.48e-13
Signal Transduction 1869 7.70e-23 9.58e-21 0.156 0.0684 0.1400 9.87e-07 1.51e-23
FCGR activation 75 8.30e-23 9.58e-21 0.494 0.0799 -0.4880 2.31e-01 2.73e-13
Creation of C4 and C2 activators 70 8.44e-23 9.58e-21 0.497 0.1120 -0.4840 1.06e-01 2.41e-12
Initial triggering of complement 77 1.26e-22 1.32e-20 0.471 0.1090 -0.4580 9.93e-02 3.62e-12
Post-translational protein modification 1183 1.18e-21 1.15e-19 0.208 0.1260 0.1660 2.77e-13 6.39e-22
Signaling by Interleukins 385 3.30e-21 3.00e-19 0.361 0.2740 0.2350 2.66e-20 2.17e-15
CD22 mediated BCR regulation 58 2.23e-20 1.90e-18 0.539 0.0690 -0.5340 3.63e-01 1.87e-12
Translation 294 4.72e-20 3.78e-18 0.242 0.2410 -0.0243 1.16e-12 4.74e-01
Regulation of Complement cascade 93 1.30e-19 9.59e-18 0.366 0.1740 -0.3220 3.80e-03 7.80e-08
rRNA processing in the nucleus and cytosol 189 1.34e-19 9.59e-18 0.279 0.0661 -0.2710 1.17e-01 1.30e-10
Role of LAT2/NTAL/LAB on calcium mobilization 73 1.98e-19 1.30e-17 0.426 0.1500 -0.3990 2.71e-02 3.62e-09
Binding and Uptake of Ligands by Scavenger Receptors 91 2.01e-19 1.30e-17 0.360 0.2140 -0.2890 4.13e-04 1.92e-06
Complement cascade 97 2.43e-19 1.51e-17 0.356 0.1690 -0.3130 3.96e-03 1.00e-07
Platelet activation, signaling and aggregation 219 1.75e-18 1.03e-16 0.405 0.1960 0.3540 5.63e-07 1.72e-19
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.42e-18 1.38e-16 0.276 0.0668 -0.2680 1.23e-01 6.03e-10
Asparagine N-linked glycosylation 269 1.43e-17 7.80e-16 0.387 0.2430 0.3020 7.07e-12 1.48e-17
FCERI mediated NF-kB activation 136 3.65e-17 1.89e-15 0.300 0.2880 -0.0861 6.79e-09 8.32e-02
Role of phospholipids in phagocytosis 87 3.75e-17 1.89e-15 0.401 0.0544 -0.3970 3.81e-01 1.45e-10
Signaling by Receptor Tyrosine Kinases 408 6.64e-17 3.23e-15 0.288 0.1440 0.2490 5.50e-07 6.16e-18
ER to Golgi Anterograde Transport 129 4.01e-16 1.88e-14 0.522 0.3040 0.4240 2.52e-09 8.03e-17
Interleukin-1 signaling 97 4.68e-16 2.13e-14 0.619 0.4670 0.4060 1.77e-15 4.61e-12
The citric acid (TCA) cycle and respiratory electron transport 172 1.46e-15 6.41e-14 0.456 0.3510 0.2900 1.93e-15 4.96e-11
Response to elevated platelet cytosolic Ca2+ 108 1.77e-15 7.55e-14 0.569 0.3530 0.4460 2.17e-10 1.17e-15
Platelet degranulation 104 5.72e-15 2.36e-13 0.572 0.3630 0.4420 1.51e-10 6.13e-15
Metabolism of lipids 619 8.44e-15 3.38e-13 0.226 0.1240 0.1890 1.28e-07 9.92e-16
rRNA processing 218 9.52e-15 3.71e-13 0.242 0.0186 -0.2410 6.36e-01 7.96e-10
Antigen processing-Cross presentation 97 1.34e-14 5.09e-13 0.581 0.4570 0.3600 7.43e-15 9.10e-10
FCERI mediated Ca+2 mobilization 88 1.90e-14 6.96e-13 0.360 0.0586 -0.3550 3.42e-01 8.57e-09
Metabolism of RNA 686 1.94e-14 6.96e-13 0.126 0.1220 -0.0309 5.16e-08 1.67e-01
FCERI mediated MAPK activation 89 2.28e-14 7.96e-13 0.318 0.1520 -0.2790 1.29e-02 5.51e-06
Disease 1339 2.57e-14 8.76e-13 0.160 0.1250 0.1010 1.99e-14 6.27e-10
Toll-like Receptor Cascades 143 3.96e-14 1.32e-12 0.479 0.3220 0.3540 2.73e-11 2.48e-13
Transport to the Golgi and subsequent modification 155 7.81e-14 2.53e-12 0.424 0.2230 0.3610 1.74e-06 8.01e-15
FCGR3A-mediated IL10 synthesis 98 8.68e-14 2.75e-12 0.334 0.0521 -0.3300 3.72e-01 1.69e-08
Hemostasis 542 1.02e-13 3.17e-12 0.245 0.1660 0.1800 4.31e-11 6.88e-13
Cellular responses to external stimuli 503 1.05e-13 3.19e-12 0.246 0.1980 0.1460 2.49e-14 2.30e-08
Transport of small molecules 554 2.73e-13 8.08e-12 0.238 0.1600 0.1760 1.31e-10 1.22e-12
Cellular responses to stress 497 3.13e-13 9.09e-12 0.242 0.1960 0.1420 6.60e-14 5.74e-08
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 3.60e-13 1.02e-11 0.491 0.3780 0.3140 3.72e-13 1.50e-09
Programmed Cell Death 179 4.51e-13 1.25e-11 0.405 0.3170 0.2520 2.46e-13 5.87e-09
Interleukin-1 family signaling 124 5.86e-13 1.60e-11 0.492 0.3590 0.3360 4.74e-12 9.59e-11


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.low.CRP s.high.CRP p.low.CRP p.high.CRP
Neutrophil degranulation 456 5.75e-107 7.84e-104 0.76000 0.536000 0.539000 3.01e-86 2.42e-87
Innate Immune System 963 8.82e-86 6.01e-83 0.47000 0.357000 0.306000 4.15e-79 2.68e-58
Immune System 1885 3.55e-42 1.61e-39 0.24100 0.182000 0.158000 3.38e-39 8.29e-30
Membrane Trafficking 555 5.19e-40 1.77e-37 0.38700 0.197000 0.333000 2.01e-15 3.07e-41
Metabolism 1758 1.93e-34 5.26e-32 0.22400 0.170000 0.145000 1.72e-32 4.24e-24
Metabolism of proteins 1706 2.40e-31 5.44e-29 0.21600 0.164000 0.141000 1.35e-29 3.77e-22
Scavenging of heme from plasma 70 3.83e-27 7.46e-25 0.51300 0.192000 -0.476000 5.38e-03 5.82e-12
Vesicle-mediated transport 644 5.08e-27 8.66e-25 0.31600 0.200000 0.245000 4.78e-18 2.49e-26
Classical antibody-mediated complement activation 68 3.04e-23 4.60e-21 0.51700 0.098600 -0.507000 1.60e-01 4.48e-13
Signal Transduction 1869 7.70e-23 9.58e-21 0.15600 0.068400 0.140000 9.87e-07 1.51e-23
FCGR activation 75 8.30e-23 9.58e-21 0.49400 0.079900 -0.488000 2.31e-01 2.73e-13
Creation of C4 and C2 activators 70 8.44e-23 9.58e-21 0.49700 0.112000 -0.484000 1.06e-01 2.41e-12
Initial triggering of complement 77 1.26e-22 1.32e-20 0.47100 0.109000 -0.458000 9.93e-02 3.62e-12
Post-translational protein modification 1183 1.18e-21 1.15e-19 0.20800 0.126000 0.166000 2.77e-13 6.39e-22
Signaling by Interleukins 385 3.30e-21 3.00e-19 0.36100 0.274000 0.235000 2.66e-20 2.17e-15
CD22 mediated BCR regulation 58 2.23e-20 1.90e-18 0.53900 0.069000 -0.534000 3.63e-01 1.87e-12
Translation 294 4.72e-20 3.78e-18 0.24200 0.241000 -0.024300 1.16e-12 4.74e-01
Regulation of Complement cascade 93 1.30e-19 9.59e-18 0.36600 0.174000 -0.322000 3.80e-03 7.80e-08
rRNA processing in the nucleus and cytosol 189 1.34e-19 9.59e-18 0.27900 0.066100 -0.271000 1.17e-01 1.30e-10
Role of LAT2/NTAL/LAB on calcium mobilization 73 1.98e-19 1.30e-17 0.42600 0.150000 -0.399000 2.71e-02 3.62e-09
Binding and Uptake of Ligands by Scavenger Receptors 91 2.01e-19 1.30e-17 0.36000 0.214000 -0.289000 4.13e-04 1.92e-06
Complement cascade 97 2.43e-19 1.51e-17 0.35600 0.169000 -0.313000 3.96e-03 1.00e-07
Platelet activation, signaling and aggregation 219 1.75e-18 1.03e-16 0.40500 0.196000 0.354000 5.63e-07 1.72e-19
Major pathway of rRNA processing in the nucleolus and cytosol 179 2.42e-18 1.38e-16 0.27600 0.066800 -0.268000 1.23e-01 6.03e-10
Asparagine N-linked glycosylation 269 1.43e-17 7.80e-16 0.38700 0.243000 0.302000 7.07e-12 1.48e-17
FCERI mediated NF-kB activation 136 3.65e-17 1.89e-15 0.30000 0.288000 -0.086100 6.79e-09 8.32e-02
Role of phospholipids in phagocytosis 87 3.75e-17 1.89e-15 0.40100 0.054400 -0.397000 3.81e-01 1.45e-10
Signaling by Receptor Tyrosine Kinases 408 6.64e-17 3.23e-15 0.28800 0.144000 0.249000 5.50e-07 6.16e-18
ER to Golgi Anterograde Transport 129 4.01e-16 1.88e-14 0.52200 0.304000 0.424000 2.52e-09 8.03e-17
Interleukin-1 signaling 97 4.68e-16 2.13e-14 0.61900 0.467000 0.406000 1.77e-15 4.61e-12
The citric acid (TCA) cycle and respiratory electron transport 172 1.46e-15 6.41e-14 0.45600 0.351000 0.290000 1.93e-15 4.96e-11
Response to elevated platelet cytosolic Ca2+ 108 1.77e-15 7.55e-14 0.56900 0.353000 0.446000 2.17e-10 1.17e-15
Platelet degranulation 104 5.72e-15 2.36e-13 0.57200 0.363000 0.442000 1.51e-10 6.13e-15
Metabolism of lipids 619 8.44e-15 3.38e-13 0.22600 0.124000 0.189000 1.28e-07 9.92e-16
rRNA processing 218 9.52e-15 3.71e-13 0.24200 0.018600 -0.241000 6.36e-01 7.96e-10
Antigen processing-Cross presentation 97 1.34e-14 5.09e-13 0.58100 0.457000 0.360000 7.43e-15 9.10e-10
FCERI mediated Ca+2 mobilization 88 1.90e-14 6.96e-13 0.36000 0.058600 -0.355000 3.42e-01 8.57e-09
Metabolism of RNA 686 1.94e-14 6.96e-13 0.12600 0.122000 -0.030900 5.16e-08 1.67e-01
FCERI mediated MAPK activation 89 2.28e-14 7.96e-13 0.31800 0.152000 -0.279000 1.29e-02 5.51e-06
Disease 1339 2.57e-14 8.76e-13 0.16000 0.125000 0.101000 1.99e-14 6.27e-10
Toll-like Receptor Cascades 143 3.96e-14 1.32e-12 0.47900 0.322000 0.354000 2.73e-11 2.48e-13
Transport to the Golgi and subsequent modification 155 7.81e-14 2.53e-12 0.42400 0.223000 0.361000 1.74e-06 8.01e-15
FCGR3A-mediated IL10 synthesis 98 8.68e-14 2.75e-12 0.33400 0.052100 -0.330000 3.72e-01 1.69e-08
Hemostasis 542 1.02e-13 3.17e-12 0.24500 0.166000 0.180000 4.31e-11 6.88e-13
Cellular responses to external stimuli 503 1.05e-13 3.19e-12 0.24600 0.198000 0.146000 2.49e-14 2.30e-08
Transport of small molecules 554 2.73e-13 8.08e-12 0.23800 0.160000 0.176000 1.31e-10 1.22e-12
Cellular responses to stress 497 3.13e-13 9.09e-12 0.24200 0.196000 0.142000 6.60e-14 5.74e-08
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 3.60e-13 1.02e-11 0.49100 0.378000 0.314000 3.72e-13 1.50e-09
Programmed Cell Death 179 4.51e-13 1.25e-11 0.40500 0.317000 0.252000 2.46e-13 5.87e-09
Interleukin-1 family signaling 124 5.86e-13 1.60e-11 0.49200 0.359000 0.336000 4.74e-12 9.59e-11
Toll Like Receptor 4 (TLR4) Cascade 121 7.69e-13 2.05e-11 0.49400 0.326000 0.371000 5.97e-10 1.80e-12
Infectious disease 773 8.59e-13 2.25e-11 0.17500 0.156000 0.078700 1.33e-13 1.97e-04
Eukaryotic Translation Elongation 92 2.03e-12 5.22e-11 0.31600 0.070800 -0.308000 2.40e-01 3.33e-07
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 3.97e-12 9.49e-11 0.54700 0.353000 0.417000 4.95e-09 4.38e-12
Toll Like Receptor 2 (TLR2) Cascade 92 3.97e-12 9.49e-11 0.54700 0.353000 0.417000 4.95e-09 4.38e-12
Toll Like Receptor TLR1:TLR2 Cascade 92 3.97e-12 9.49e-11 0.54700 0.353000 0.417000 4.95e-09 4.38e-12
Toll Like Receptor TLR6:TLR2 Cascade 92 3.97e-12 9.49e-11 0.54700 0.353000 0.417000 4.95e-09 4.38e-12
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 181 5.13e-12 1.21e-10 0.29600 -0.075100 -0.286000 8.15e-02 2.92e-11
ER-Phagosome pathway 82 6.25e-12 1.44e-10 0.55900 0.453000 0.328000 1.28e-12 2.87e-07
Formation of a pool of free 40S subunits 99 7.31e-12 1.66e-10 0.27200 0.130000 -0.240000 2.59e-02 3.76e-05
Regulation of mRNA stability by proteins that bind AU-rich elements 87 8.27e-12 1.85e-10 0.52800 0.442000 0.289000 1.03e-12 3.15e-06
Selenocysteine synthesis 91 1.16e-11 2.55e-10 0.31800 0.046600 -0.315000 4.43e-01 2.04e-07
Apoptosis 167 1.27e-11 2.75e-10 0.39300 0.309000 0.243000 5.41e-12 5.84e-08
Metabolism of amino acids and derivatives 323 1.32e-11 2.82e-10 0.18100 0.181000 -0.004500 2.29e-08 8.89e-01
Signaling by Rho GTPases 364 1.72e-11 3.61e-10 0.22300 0.080900 0.208000 8.05e-03 9.52e-12
Intra-Golgi and retrograde Golgi-to-ER traffic 179 1.84e-11 3.76e-10 0.36000 0.192000 0.304000 8.89e-06 2.15e-12
Respiratory electron transport 101 1.86e-11 3.76e-10 0.50300 0.391000 0.317000 1.08e-11 3.80e-08
Peptide chain elongation 87 1.87e-11 3.76e-10 0.31500 0.061700 -0.309000 3.20e-01 6.31e-07
Diseases of signal transduction by growth factor receptors and second messengers 339 1.99e-11 3.94e-10 0.27200 0.163000 0.218000 2.35e-07 5.31e-12
Fc epsilon receptor (FCERI) signaling 189 2.09e-11 4.07e-10 0.23700 0.237000 0.000690 1.79e-08 9.87e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 2.25e-11 4.33e-10 0.24500 0.172000 -0.174000 1.80e-03 1.60e-03
Selenoamino acid metabolism 113 2.35e-11 4.45e-10 0.25500 0.100000 -0.235000 6.63e-02 1.62e-05
Translocation of ZAP-70 to Immunological synapse 24 2.61e-11 4.87e-10 0.98700 -0.550000 -0.819000 3.10e-06 3.60e-12
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.64e-11 4.87e-10 0.24500 0.174000 -0.173000 1.66e-03 1.86e-03
Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 53 3.67e-11 6.67e-10 0.66800 0.545000 0.386000 6.52e-12 1.17e-06
COPI-mediated anterograde transport 78 5.18e-11 9.29e-10 0.55500 0.338000 0.441000 2.53e-07 1.62e-11
Viral mRNA Translation 87 5.41e-11 9.57e-10 0.29800 0.081200 -0.287000 1.90e-01 3.71e-06
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 5.94e-11 1.04e-09 0.33600 0.022600 -0.335000 7.21e-01 1.29e-07
Regulation of ornithine decarboxylase (ODC) 49 6.29e-11 1.09e-09 0.68300 0.562000 0.387000 9.77e-12 2.70e-06
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 6.63e-11 1.13e-09 0.26900 0.099500 -0.249000 8.70e-02 1.79e-05
SRP-dependent cotranslational protein targeting to membrane 110 8.81e-11 1.48e-09 0.23900 0.187000 -0.149000 6.95e-04 6.94e-03
Eukaryotic Translation Termination 91 9.00e-11 1.50e-09 0.29600 0.062800 -0.289000 3.01e-01 1.85e-06
Regulation of Apoptosis 51 9.12e-11 1.50e-09 0.65300 0.549000 0.353000 1.13e-11 1.26e-05
Defective CFTR causes cystic fibrosis 58 9.45e-11 1.53e-09 0.63000 0.509000 0.372000 2.04e-11 9.73e-07
Clathrin-mediated endocytosis 125 1.01e-10 1.61e-09 0.39200 0.179000 0.349000 5.66e-04 1.52e-11
Signaling by NOTCH 182 1.21e-10 1.92e-09 0.35300 0.205000 0.287000 1.83e-06 2.25e-11
NIK–>noncanonical NF-kB signaling 57 1.30e-10 2.04e-09 0.60800 0.516000 0.321000 1.54e-11 2.68e-05
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.33e-10 2.07e-09 0.64100 0.533000 0.356000 1.85e-11 7.13e-06
Cross-presentation of soluble exogenous antigens (endosomes) 47 1.46e-10 2.23e-09 0.68800 0.562000 0.397000 2.57e-11 2.46e-06
Cap-dependent Translation Initiation 117 1.50e-10 2.24e-09 0.22900 0.174000 -0.149000 1.17e-03 5.42e-03
Eukaryotic Translation Initiation 117 1.50e-10 2.24e-09 0.22900 0.174000 -0.149000 1.17e-03 5.42e-03
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 1.52e-10 2.25e-09 0.27800 0.087300 -0.263000 1.46e-01 1.13e-05
Hh mutants abrogate ligand secretion 54 1.81e-10 2.65e-09 0.63700 0.523000 0.363000 2.95e-11 3.84e-06
Metabolism of polyamines 57 1.84e-10 2.67e-09 0.60000 0.512000 0.312000 2.16e-11 4.49e-05
Degradation of GLI2 by the proteasome 56 2.30e-10 3.26e-09 0.61800 0.512000 0.346000 3.32e-11 7.62e-06
GLI3 is processed to GLI3R by the proteasome 56 2.30e-10 3.26e-09 0.61800 0.512000 0.346000 3.32e-11 7.62e-06
CLEC7A (Dectin-1) signaling 96 2.50e-10 3.51e-09 0.48500 0.383000 0.298000 8.76e-11 4.45e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 2.60e-10 3.62e-09 0.66300 0.552000 0.367000 3.56e-11 1.11e-05
Hedgehog ligand biogenesis 58 2.71e-10 3.71e-09 0.61300 0.498000 0.356000 5.09e-11 2.70e-06
Autophagy 123 2.74e-10 3.71e-09 0.43800 0.306000 0.313000 4.39e-09 2.09e-09
Dectin-1 mediated noncanonical NF-kB signaling 58 2.75e-10 3.71e-09 0.59300 0.503000 0.314000 3.31e-11 3.56e-05
The role of GTSE1 in G2/M progression after G2 checkpoint 58 3.09e-10 4.13e-09 0.58500 0.502000 0.301000 3.64e-11 7.50e-05
Influenza Viral RNA Transcription and Replication 134 3.86e-10 5.10e-09 0.23300 0.056100 -0.227000 2.62e-01 5.91e-06
C-type lectin receptors (CLRs) 128 4.07e-10 5.34e-09 0.41600 0.328000 0.255000 1.41e-10 5.98e-07
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 4.62e-10 6.00e-09 0.62500 0.524000 0.339000 5.98e-11 2.29e-05
RHO GTPase Effectors 248 4.73e-10 6.08e-09 0.27400 0.131000 0.241000 3.86e-04 6.23e-11
Vif-mediated degradation of APOBEC3G 52 4.96e-10 6.32e-09 0.63000 0.522000 0.353000 7.29e-11 1.05e-05
Negative regulation of NOTCH4 signaling 54 5.24e-10 6.61e-09 0.61300 0.513000 0.335000 6.95e-11 2.03e-05
Cellular response to hypoxia 71 5.74e-10 7.17e-09 0.56500 0.412000 0.386000 1.84e-09 1.87e-08
Degradation of GLI1 by the proteasome 57 6.15e-10 7.63e-09 0.59900 0.496000 0.336000 9.16e-11 1.11e-05
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 6.52e-10 7.87e-09 0.63100 0.531000 0.341000 8.37e-11 3.01e-05
p53-Independent DNA Damage Response 50 6.52e-10 7.87e-09 0.63100 0.531000 0.341000 8.37e-11 3.01e-05
p53-Independent G1/S DNA damage checkpoint 50 6.52e-10 7.87e-09 0.63100 0.531000 0.341000 8.37e-11 3.01e-05
TNFR2 non-canonical NF-kB pathway 95 6.89e-10 8.24e-09 0.36500 0.354000 0.089200 2.46e-09 1.33e-01
Golgi-to-ER retrograde transport 111 7.08e-10 8.39e-09 0.44300 0.279000 0.345000 3.89e-07 3.43e-10
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 8.14e-10 9.56e-09 0.49000 0.431000 0.234000 1.08e-10 4.61e-04
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 8.51e-10 9.91e-09 0.50400 0.442000 0.240000 1.13e-10 4.58e-04
Autodegradation of Cdh1 by Cdh1:APC/C 64 8.68e-10 1.00e-08 0.54700 0.467000 0.286000 1.06e-10 7.53e-05
APC/C:Cdc20 mediated degradation of mitotic proteins 74 9.19e-10 1.05e-08 0.49000 0.432000 0.231000 1.27e-10 5.93e-04
APC/C:Cdc20 mediated degradation of Securin 66 9.94e-10 1.13e-08 0.54200 0.458000 0.290000 1.26e-10 4.54e-05
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 1.07e-09 1.21e-08 0.49500 0.437000 0.234000 1.48e-10 5.99e-04
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.37e-09 1.53e-08 0.57600 0.444000 0.367000 8.09e-10 3.83e-07
Vpu mediated degradation of CD4 50 1.44e-09 1.60e-08 0.61800 0.521000 0.334000 1.87e-10 4.41e-05
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 87 1.61e-09 1.77e-08 0.49600 0.327000 0.373000 1.35e-07 1.88e-09
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 1.71e-09 1.86e-08 0.51700 0.432000 0.285000 2.38e-10 2.83e-05
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 1.82e-09 1.96e-08 0.48900 0.324000 0.366000 1.30e-07 2.29e-09
Regulation of expression of SLITs and ROBOs 158 2.12e-09 2.28e-08 0.21200 0.208000 -0.039300 6.50e-06 3.94e-01
Regulation of APC/C activators between G1/S and early anaphase 79 2.22e-09 2.35e-08 0.45500 0.408000 0.203000 3.72e-10 1.79e-03
Anti-inflammatory response favouring Leishmania parasite infection 167 2.24e-09 2.35e-08 0.19700 0.055900 -0.189000 2.13e-01 2.51e-05
Leishmania parasite growth and survival 167 2.24e-09 2.35e-08 0.19700 0.055900 -0.189000 2.13e-01 2.51e-05
PD-1 signaling 28 2.29e-09 2.38e-08 0.78100 -0.372000 -0.687000 6.63e-04 3.12e-10
RUNX1 regulates transcription of genes involved in differentiation of HSCs 82 2.77e-09 2.85e-08 0.50700 0.361000 0.356000 1.63e-08 2.51e-08
SCF-beta-TrCP mediated degradation of Emi1 53 2.78e-09 2.85e-08 0.57700 0.498000 0.292000 3.46e-10 2.35e-04
COPII-mediated vesicle transport 65 2.83e-09 2.88e-08 0.54000 0.302000 0.448000 2.50e-05 4.23e-10
APC/C-mediated degradation of cell cycle proteins 86 2.88e-09 2.88e-08 0.43200 0.388000 0.190000 5.07e-10 2.27e-03
Regulation of mitotic cell cycle 86 2.88e-09 2.88e-08 0.43200 0.388000 0.190000 5.07e-10 2.27e-03
ABC transporter disorders 69 3.39e-09 3.37e-08 0.53400 0.427000 0.321000 8.59e-10 4.05e-06
Ubiquitin-dependent degradation of Cyclin D 50 4.17e-09 4.12e-08 0.60400 0.507000 0.328000 5.64e-10 5.93e-05
Signaling by WNT 253 4.40e-09 4.32e-08 0.25100 0.112000 0.225000 2.23e-03 7.51e-10
ROS and RNS production in phagocytes 31 4.57e-09 4.45e-08 0.80600 0.610000 0.528000 4.14e-09 3.65e-07
trans-Golgi Network Vesicle Budding 69 4.62e-09 4.46e-08 0.50800 0.269000 0.431000 1.13e-04 5.92e-10
Detoxification of Reactive Oxygen Species 31 4.79e-09 4.60e-08 0.80700 0.605000 0.533000 5.35e-09 2.73e-07
MyD88 dependent cascade initiated on endosome 88 5.14e-09 4.90e-08 0.47900 0.316000 0.359000 2.96e-07 5.59e-09
Degradation of DVL 54 5.38e-09 5.09e-08 0.58900 0.481000 0.340000 9.71e-10 1.53e-05
CDK-mediated phosphorylation and removal of Cdc6 71 5.59e-09 5.26e-08 0.49400 0.423000 0.256000 7.07e-10 1.93e-04
Toll Like Receptor 9 (TLR9) Cascade 92 5.87e-09 5.48e-08 0.46600 0.305000 0.352000 4.10e-07 5.42e-09
Signaling by NOTCH4 78 6.11e-09 5.67e-08 0.49500 0.395000 0.299000 1.63e-09 4.90e-06
Influenza Infection 153 6.30e-09 5.80e-08 0.19400 0.072300 -0.180000 1.23e-01 1.20e-04
Rab regulation of trafficking 120 7.18e-09 6.57e-08 0.33700 0.124000 0.314000 1.94e-02 2.93e-09
Signaling by NTRKs 114 1.11e-08 1.01e-07 0.40600 0.252000 0.319000 3.49e-06 3.89e-09
RAB GEFs exchange GTP for GDP on RABs 87 1.19e-08 1.08e-07 0.41400 0.184000 0.371000 3.08e-03 2.09e-09
Signaling by the B Cell Receptor (BCR) 161 1.28e-08 1.14e-07 0.19400 0.187000 -0.049900 4.15e-05 2.75e-01
RHO GTPases Activate WASPs and WAVEs 35 1.28e-08 1.14e-07 0.72000 0.425000 0.580000 1.32e-05 2.78e-09
COPI-independent Golgi-to-ER retrograde traffic 33 1.39e-08 1.23e-07 0.72600 0.406000 0.602000 5.34e-05 2.14e-09
Autodegradation of the E3 ubiquitin ligase COP1 49 1.44e-08 1.27e-07 0.58300 0.496000 0.307000 1.89e-09 2.00e-04
CDT1 association with the CDC6:ORC:origin complex 57 1.64e-08 1.43e-07 0.52700 0.458000 0.261000 2.18e-09 6.58e-04
MyD88 cascade initiated on plasma membrane 82 1.81e-08 1.55e-07 0.47500 0.301000 0.367000 2.40e-06 8.68e-09
Toll Like Receptor 10 (TLR10) Cascade 82 1.81e-08 1.55e-07 0.47500 0.301000 0.367000 2.40e-06 8.68e-09
Toll Like Receptor 5 (TLR5) Cascade 82 1.81e-08 1.55e-07 0.47500 0.301000 0.367000 2.40e-06 8.68e-09
Activation of NF-kappaB in B cells 65 1.90e-08 1.62e-07 0.52100 0.423000 0.304000 3.71e-09 2.28e-05
Class I MHC mediated antigen processing & presentation 347 1.92e-08 1.63e-07 0.23400 0.155000 0.175000 6.89e-07 1.99e-08
Cell surface interactions at the vascular wall 172 1.95e-08 1.64e-07 0.18700 0.182000 -0.044300 3.98e-05 3.16e-01
Regulation of PTEN stability and activity 66 2.68e-08 2.24e-07 0.52800 0.395000 0.351000 2.84e-08 8.12e-07
SCF(Skp2)-mediated degradation of p27/p21 60 2.96e-08 2.46e-07 0.50300 0.439000 0.246000 4.06e-09 9.92e-04
EPH-Ephrin signaling 78 3.12e-08 2.58e-07 0.48500 0.327000 0.359000 6.11e-07 4.35e-08
Generation of second messenger molecules 38 4.49e-08 3.69e-07 0.63400 -0.324000 -0.545000 5.52e-04 5.99e-09
Stabilization of p53 54 5.25e-08 4.28e-07 0.53900 0.455000 0.290000 7.34e-09 2.26e-04
MyD88-independent TLR4 cascade 96 5.83e-08 4.70e-07 0.43000 0.292000 0.315000 7.40e-07 9.40e-08
TRIF(TICAM1)-mediated TLR4 signaling 96 5.83e-08 4.70e-07 0.43000 0.292000 0.315000 7.40e-07 9.40e-08
HIV Infection 224 6.15e-08 4.93e-07 0.27400 0.220000 0.162000 1.38e-08 2.80e-05
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 6.37e-08 5.05e-07 0.21400 0.071000 -0.202000 1.93e-01 2.03e-04
Nonsense-Mediated Decay (NMD) 113 6.37e-08 5.05e-07 0.21400 0.071000 -0.202000 1.93e-01 2.03e-04
Degradation of AXIN 53 7.74e-08 6.10e-07 0.54100 0.453000 0.294000 1.12e-08 2.09e-04
PPARA activates gene expression 104 1.11e-07 8.72e-07 0.33500 0.123000 0.311000 2.96e-02 4.06e-08
Regulation of actin dynamics for phagocytic cup formation 122 1.16e-07 9.04e-07 0.20700 0.199000 -0.057500 1.52e-04 2.73e-01
Cytokine Signaling in Immune system 733 1.39e-07 1.07e-06 0.14400 0.122000 0.076400 1.95e-08 4.32e-04
Developmental Biology 726 1.49e-07 1.14e-06 0.15100 0.093700 0.119000 1.73e-05 4.86e-08
MAPK6/MAPK4 signaling 82 1.56e-07 1.19e-06 0.43500 0.354000 0.254000 3.07e-08 7.06e-05
Signaling by NTRK1 (TRKA) 100 1.61e-07 1.22e-06 0.40100 0.249000 0.314000 1.62e-05 5.52e-08
Macroautophagy 109 1.67e-07 1.27e-06 0.39100 0.268000 0.285000 1.36e-06 2.80e-07
Regulation of RUNX3 expression and activity 55 2.11e-07 1.59e-06 0.52300 0.429000 0.299000 3.75e-08 1.26e-04
Hedgehog ‘on’ state 74 2.24e-07 1.67e-06 0.45000 0.369000 0.256000 3.94e-08 1.36e-04
Chromatin modifying enzymes 217 2.26e-07 1.67e-06 0.13800 -0.097700 0.097800 1.32e-02 1.31e-02
Chromatin organization 217 2.26e-07 1.67e-06 0.13800 -0.097700 0.097800 1.32e-02 1.31e-02
Phosphorylation of CD3 and TCR zeta chains 27 2.34e-07 1.73e-06 0.75800 -0.463000 -0.600000 3.13e-05 6.63e-08
PCP/CE pathway 86 3.06e-07 2.24e-06 0.43100 0.292000 0.317000 2.94e-06 3.74e-07
Downstream signaling events of B Cell Receptor (BCR) 79 3.33e-07 2.43e-06 0.43200 0.351000 0.252000 6.58e-08 1.07e-04
Regulation of RUNX2 expression and activity 66 3.52e-07 2.55e-06 0.44800 0.388000 0.225000 5.02e-08 1.55e-03
Mitochondrial translation 97 4.02e-07 2.90e-06 0.29500 0.288000 0.062300 9.55e-07 2.89e-01
Golgi Associated Vesicle Biogenesis 55 4.29e-07 3.07e-06 0.50100 0.272000 0.421000 4.82e-04 6.46e-08
Interleukin-4 and Interleukin-13 signaling 92 4.35e-07 3.11e-06 0.38400 0.326000 0.203000 6.31e-08 7.44e-04
Regulation of lipid metabolism by PPARalpha 106 4.43e-07 3.15e-06 0.31200 0.109000 0.293000 5.23e-02 1.91e-07
ABC-family proteins mediated transport 92 4.57e-07 3.23e-06 0.39600 0.322000 0.230000 8.95e-08 1.33e-04
Pre-NOTCH Expression and Processing 65 4.84e-07 3.40e-06 0.32800 0.028700 0.326000 6.89e-01 5.36e-06
Cargo concentration in the ER 30 5.35e-07 3.74e-06 0.69900 0.425000 0.555000 5.63e-05 1.44e-07
G1/S DNA Damage Checkpoints 65 5.79e-07 4.02e-06 0.44900 0.384000 0.232000 8.35e-08 1.19e-03
Axon guidance 451 6.55e-07 4.53e-06 0.18000 0.144000 0.109000 1.68e-07 7.16e-05
FCGR3A-mediated phagocytosis 120 7.02e-07 4.78e-06 0.18600 0.167000 -0.081300 1.55e-03 1.24e-01
Leishmania phagocytosis 120 7.02e-07 4.78e-06 0.18600 0.167000 -0.081300 1.55e-03 1.24e-01
Parasite infection 120 7.02e-07 4.78e-06 0.18600 0.167000 -0.081300 1.55e-03 1.24e-01
RHO GTPases activate PKNs 47 7.63e-07 5.17e-06 0.48300 0.198000 0.440000 1.87e-02 1.78e-07
Degradation of beta-catenin by the destruction complex 83 7.78e-07 5.25e-06 0.41200 0.332000 0.245000 1.76e-07 1.12e-04
Cargo recognition for clathrin-mediated endocytosis 88 9.06e-07 6.09e-06 0.36900 0.175000 0.324000 4.43e-03 1.42e-07
EPHB-mediated forward signaling 32 1.00e-06 6.70e-06 0.67800 0.493000 0.465000 1.40e-06 5.27e-06
p53-Dependent G1 DNA Damage Response 63 1.16e-06 7.65e-06 0.44900 0.381000 0.238000 1.74e-07 1.07e-03
p53-Dependent G1/S DNA damage checkpoint 63 1.16e-06 7.65e-06 0.44900 0.381000 0.238000 1.74e-07 1.07e-03
Antimicrobial peptides 33 1.16e-06 7.65e-06 0.60600 0.525000 0.302000 1.73e-07 2.70e-03
Mitochondrial translation termination 91 1.20e-06 7.90e-06 0.28400 0.280000 0.048600 3.93e-06 4.23e-01
Post-translational protein phosphorylation 68 1.23e-06 8.01e-06 0.45700 0.292000 0.351000 3.15e-05 5.45e-07
Deubiquitination 240 1.26e-06 8.19e-06 0.24500 0.162000 0.184000 1.60e-05 8.53e-07
Mitochondrial translation elongation 91 1.30e-06 8.38e-06 0.28000 0.277000 0.043700 5.00e-06 4.71e-01
Metabolism of nucleotides 86 1.33e-06 8.56e-06 0.31800 0.305000 0.092400 1.04e-06 1.38e-01
PTEN Regulation 138 1.41e-06 9.04e-06 0.31800 0.198000 0.248000 5.90e-05 4.75e-07
IRAK4 deficiency (TLR2/4) 10 1.45e-06 9.18e-06 1.19000 0.813000 0.875000 8.51e-06 1.65e-06
MyD88 deficiency (TLR2/4) 10 1.45e-06 9.18e-06 1.19000 0.813000 0.875000 8.51e-06 1.65e-06
Synthesis of DNA 118 1.63e-06 1.03e-05 0.21300 0.213000 -0.012700 6.56e-05 8.12e-01
Iron uptake and transport 52 1.86e-06 1.17e-05 0.51900 0.384000 0.348000 1.62e-06 1.41e-05
Intracellular signaling by second messengers 271 1.90e-06 1.19e-05 0.20400 0.095800 0.181000 6.62e-03 3.13e-07
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 2.22e-06 1.37e-05 1.07000 0.713000 0.798000 1.90e-05 1.69e-06
alpha-linolenic acid (ALA) metabolism 12 2.22e-06 1.37e-05 1.07000 0.713000 0.798000 1.90e-05 1.69e-06
Switching of origins to a post-replicative state 89 2.22e-06 1.37e-05 0.33000 0.305000 0.126000 6.67e-07 4.06e-02
Endosomal Sorting Complex Required For Transport (ESCRT) 29 2.53e-06 1.56e-05 0.68800 0.489000 0.484000 5.07e-06 6.42e-06
rRNA modification in the nucleus and cytosol 59 2.54e-06 1.56e-05 0.29000 0.027300 -0.289000 7.17e-01 1.22e-04
Nervous system development 470 2.58e-06 1.57e-05 0.16900 0.133000 0.105000 8.19e-07 9.50e-05
MAP2K and MAPK activation 34 2.70e-06 1.63e-05 0.61600 0.370000 0.493000 1.86e-04 6.56e-07
Mitochondrial translation initiation 91 2.72e-06 1.64e-05 0.27700 0.273000 0.050000 6.89e-06 4.10e-01
Ub-specific processing proteases 169 2.78e-06 1.67e-05 0.28300 0.213000 0.186000 1.70e-06 3.02e-05
PIP3 activates AKT signaling 239 3.01e-06 1.80e-05 0.21900 0.110000 0.189000 3.42e-03 4.62e-07
Orc1 removal from chromatin 69 3.05e-06 1.82e-05 0.37200 0.343000 0.144000 8.55e-07 3.80e-02
Beta-catenin independent WNT signaling 136 3.30e-06 1.96e-05 0.31100 0.197000 0.240000 7.20e-05 1.29e-06
DNA strand elongation 32 3.43e-06 2.03e-05 0.53700 -0.201000 -0.498000 4.96e-02 1.09e-06
Insulin receptor recycling 21 3.68e-06 2.16e-05 0.79700 0.568000 0.559000 6.62e-06 9.21e-06
Regulation of TLR by endogenous ligand 11 4.26e-06 2.48e-05 1.09000 0.798000 0.746000 4.59e-06 1.81e-05
DNA Replication 125 4.26e-06 2.48e-05 0.20500 0.205000 -0.002080 7.42e-05 9.68e-01
HDACs deacetylate histones 47 4.33e-06 2.51e-05 0.37300 0.059700 0.368000 4.79e-01 1.26e-05
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 78 4.80e-06 2.77e-05 0.40500 0.262000 0.310000 6.46e-05 2.25e-06
Assembly of the pre-replicative complex 66 5.29e-06 3.04e-05 0.40000 0.350000 0.193000 8.60e-07 6.64e-03
MAP kinase activation 63 5.52e-06 3.16e-05 0.44600 0.282000 0.346000 1.09e-04 2.03e-06
Interleukin-17 signaling 68 5.99e-06 3.41e-05 0.42700 0.268000 0.333000 1.29e-04 2.09e-06
Transferrin endocytosis and recycling 26 6.00e-06 3.41e-05 0.70100 0.481000 0.510000 2.15e-05 6.73e-06
Formation of the ternary complex, and subsequently, the 43S complex 51 6.50e-06 3.68e-05 0.25400 0.209000 -0.144000 9.78e-03 7.49e-02
Toll Like Receptor 3 (TLR3) Cascade 92 6.90e-06 3.89e-05 0.37100 0.251000 0.273000 3.11e-05 6.18e-06
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 6.94e-06 3.89e-05 0.26000 0.253000 -0.061800 7.78e-04 4.12e-01
Translation initiation complex formation 58 7.17e-06 4.01e-05 0.25700 0.246000 -0.074100 1.20e-03 3.29e-01
Signaling by Nuclear Receptors 214 7.27e-06 4.04e-05 0.22200 0.111000 0.193000 5.17e-03 1.16e-06
Budding and maturation of HIV virion 26 7.33e-06 4.06e-05 0.69600 0.480000 0.503000 2.23e-05 8.90e-06
Cyclin E associated events during G1/S transition 83 7.39e-06 4.08e-05 0.36300 0.308000 0.192000 1.18e-06 2.54e-03
Signaling by ROBO receptors 198 7.49e-06 4.11e-05 0.15900 0.159000 -0.002830 1.17e-04 9.45e-01
Asymmetric localization of PCP proteins 60 7.60e-06 4.16e-05 0.44400 0.356000 0.265000 1.78e-06 3.83e-04
G1/S Transition 130 7.63e-06 4.16e-05 0.20300 0.203000 0.009170 6.42e-05 8.57e-01
L1CAM interactions 83 8.42e-06 4.57e-05 0.34200 0.154000 0.305000 1.52e-02 1.57e-06
ESR-mediated signaling 159 8.53e-06 4.61e-05 0.25400 0.124000 0.222000 7.19e-03 1.40e-06
Complex I biogenesis 55 1.04e-05 5.58e-05 0.47200 0.341000 0.325000 1.19e-05 2.98e-05
Amyloid fiber formation 51 1.04e-05 5.58e-05 0.47300 0.277000 0.383000 6.15e-04 2.22e-06
RAB geranylgeranylation 61 1.06e-05 5.66e-05 0.43900 0.273000 0.344000 2.25e-04 3.32e-06
Smooth Muscle Contraction 30 1.08e-05 5.75e-05 0.63100 0.406000 0.483000 1.18e-04 4.74e-06
Ribosomal scanning and start codon recognition 58 1.35e-05 7.15e-05 0.24800 0.236000 -0.076000 1.85e-03 3.17e-01
Signaling by BRAF and RAF fusions 57 1.35e-05 7.15e-05 0.45200 0.287000 0.349000 1.81e-04 5.08e-06
Protein localization 157 1.36e-05 7.18e-05 0.25400 0.219000 0.129000 2.21e-06 5.18e-03
Neddylation 217 1.43e-05 7.51e-05 0.23100 0.144000 0.180000 2.52e-04 4.64e-06
MAPK family signaling cascades 267 1.71e-05 8.96e-05 0.20900 0.139000 0.157000 9.23e-05 1.05e-05
Signaling by MET 60 1.78e-05 9.24e-05 0.41800 0.233000 0.348000 1.84e-03 3.18e-06
TCF dependent signaling in response to WNT 165 1.85e-05 9.58e-05 0.24800 0.131000 0.211000 3.56e-03 3.07e-06
Fcgamma receptor (FCGR) dependent phagocytosis 146 1.93e-05 9.94e-05 0.16200 0.160000 -0.029700 8.62e-04 5.36e-01
VEGFA-VEGFR2 Pathway 90 1.94e-05 9.96e-05 0.30400 0.121000 0.278000 4.65e-02 4.95e-06
Leishmania infection 243 2.10e-05 1.07e-04 0.14100 0.141000 0.003820 1.56e-04 9.18e-01
Interferon Signaling 177 2.10e-05 1.07e-04 0.19600 -0.054700 -0.189000 2.10e-01 1.48e-05
Mitotic Anaphase 223 2.11e-05 1.08e-04 0.21900 0.178000 0.128000 4.43e-06 1.01e-03
Signaling by Hedgehog 119 2.16e-05 1.10e-04 0.30800 0.234000 0.201000 1.07e-05 1.48e-04
Extracellular matrix organization 215 2.23e-05 1.13e-04 0.20100 0.087500 0.181000 2.70e-02 4.61e-06
Regulation of RAS by GAPs 66 2.31e-05 1.16e-04 0.40900 0.318000 0.258000 8.12e-06 2.83e-04
Signaling by high-kinase activity BRAF mutants 31 2.36e-05 1.18e-04 0.58700 0.349000 0.471000 7.60e-04 5.52e-06
Mitotic Metaphase and Anaphase 224 2.43e-05 1.21e-04 0.21600 0.177000 0.123000 4.70e-06 1.52e-03
Disorders of transmembrane transporters 144 2.81e-05 1.40e-04 0.26600 0.220000 0.149000 5.23e-06 2.02e-03
Oncogenic MAPK signaling 73 2.88e-05 1.43e-04 0.38100 0.230000 0.304000 6.84e-04 7.29e-06
Transcriptional regulation by RUNX2 99 2.91e-05 1.44e-04 0.32700 0.261000 0.197000 7.28e-06 7.17e-04
MAPK1/MAPK3 signaling 233 3.13e-05 1.54e-04 0.21800 0.148000 0.161000 1.03e-04 2.35e-05
Cyclin A:Cdk2-associated events at S phase entry 85 3.17e-05 1.55e-04 0.33300 0.286000 0.172000 5.32e-06 6.07e-03
Pre-NOTCH Transcription and Translation 49 3.38e-05 1.65e-04 0.32000 0.032000 0.318000 6.98e-01 1.15e-04
Protein ubiquitination 72 3.73e-05 1.82e-04 0.38400 0.244000 0.296000 3.44e-04 1.38e-05
TP53 Regulates Metabolic Genes 85 3.89e-05 1.89e-04 0.35700 0.255000 0.250000 4.67e-05 6.84e-05
RHO GTPases Activate NADPH Oxidases 21 4.40e-05 2.13e-04 0.70600 0.453000 0.541000 3.24e-04 1.78e-05
Activation of the pre-replicative complex 32 4.51e-05 2.17e-04 0.47600 -0.174000 -0.443000 8.85e-02 1.46e-05
HDMs demethylate histones 22 4.72e-05 2.26e-04 0.34900 -0.228000 0.265000 6.42e-02 3.16e-02
Mitotic G1 phase and G1/S transition 148 4.73e-05 2.26e-04 0.18800 0.186000 0.028400 9.54e-05 5.51e-01
Cellular Senescence 144 5.04e-05 2.40e-04 0.22900 0.090500 0.210000 6.09e-02 1.33e-05
Lysosome Vesicle Biogenesis 32 5.17e-05 2.45e-04 0.55900 0.338000 0.445000 9.37e-04 1.33e-05
Interferon alpha/beta signaling 57 5.28e-05 2.50e-04 0.39300 -0.198000 -0.340000 9.69e-03 9.10e-06
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 5.74e-05 2.71e-04 0.47200 0.058000 0.468000 6.38e-01 1.42e-04
Mitochondrial protein import 64 5.86e-05 2.75e-04 0.29500 0.288000 0.063100 6.57e-05 3.83e-01
FLT3 Signaling 242 6.00e-05 2.81e-04 0.20600 0.132000 0.157000 3.90e-04 2.44e-05
Diseases associated with the TLR signaling cascade 23 6.14e-05 2.85e-04 0.67000 0.484000 0.464000 5.95e-05 1.18e-04
Diseases of Immune System 23 6.14e-05 2.85e-04 0.67000 0.484000 0.464000 5.95e-05 1.18e-04
Hyaluronan uptake and degradation 12 6.18e-05 2.86e-04 0.90000 0.537000 0.722000 1.29e-03 1.48e-05
Host Interactions of HIV factors 129 6.55e-05 3.02e-04 0.24100 0.220000 0.097800 1.62e-05 5.52e-02
Metabolism of carbohydrates 241 6.81e-05 3.13e-04 0.20000 0.117000 0.162000 1.80e-03 1.49e-05
DNA Replication Pre-Initiation 82 6.89e-05 3.16e-04 0.26000 0.253000 0.056800 7.26e-05 3.74e-01
Transcriptional regulation by RUNX3 90 6.99e-05 3.20e-04 0.32300 0.265000 0.184000 1.41e-05 2.50e-03
Downstream TCR signaling 100 7.56e-05 3.45e-04 0.23300 0.228000 0.049500 8.29e-05 3.92e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 8.04e-05 3.65e-04 0.50100 0.416000 0.279000 1.53e-05 3.75e-03
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 8.74e-05 3.96e-04 0.42400 0.347000 0.244000 1.81e-05 2.59e-03
Activation of ATR in response to replication stress 36 9.21e-05 4.16e-04 0.43500 -0.162000 -0.403000 9.21e-02 2.81e-05
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 1.03e-04 4.65e-04 0.43700 0.258000 0.352000 1.99e-03 2.38e-05
Signaling by RAF1 mutants 34 1.04e-04 4.67e-04 0.53000 0.339000 0.407000 6.23e-04 3.97e-05
Activation of HOX genes during differentiation 69 1.05e-04 4.69e-04 0.21300 -0.046300 0.208000 5.06e-01 2.78e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis 69 1.05e-04 4.69e-04 0.21300 -0.046300 0.208000 5.06e-01 2.78e-03
Cristae formation 31 1.07e-04 4.74e-04 0.55000 0.431000 0.342000 3.24e-05 9.91e-04
Separation of Sister Chromatids 167 1.07e-04 4.75e-04 0.22600 0.192000 0.119000 1.92e-05 7.95e-03
MTOR signalling 39 1.10e-04 4.83e-04 0.49500 0.320000 0.377000 5.37e-04 4.62e-05
Erythrocytes take up carbon dioxide and release oxygen 11 1.14e-04 4.96e-04 0.93800 0.670000 0.656000 1.19e-04 1.64e-04
O2/CO2 exchange in erythrocytes 11 1.14e-04 4.96e-04 0.93800 0.670000 0.656000 1.19e-04 1.64e-04
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 1.15e-04 4.96e-04 0.50300 0.337000 0.373000 3.30e-04 6.79e-05
Signaling by RAS mutants 38 1.15e-04 4.96e-04 0.50300 0.337000 0.373000 3.30e-04 6.79e-05
Signaling by moderate kinase activity BRAF mutants 38 1.15e-04 4.96e-04 0.50300 0.337000 0.373000 3.30e-04 6.79e-05
Signaling downstream of RAS mutants 38 1.15e-04 4.96e-04 0.50300 0.337000 0.373000 3.30e-04 6.79e-05
Hedgehog ‘off’ state 91 1.16e-04 4.99e-04 0.32100 0.250000 0.200000 3.63e-05 9.72e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.17e-04 5.01e-04 0.84200 0.403000 0.739000 2.06e-02 2.17e-05
Inflammasomes 20 1.23e-04 5.29e-04 0.63500 0.548000 0.322000 2.21e-05 1.27e-02
Transcriptional regulation by RUNX1 184 1.27e-04 5.41e-04 0.18900 0.070400 0.176000 9.97e-02 3.90e-05
RAF/MAP kinase cascade 228 1.27e-04 5.41e-04 0.20500 0.137000 0.153000 3.79e-04 7.13e-05
Interleukin-12 family signaling 53 1.30e-04 5.51e-04 0.39300 0.336000 0.205000 2.34e-05 9.85e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 1.35e-04 5.70e-04 0.56100 0.416000 0.375000 7.86e-05 3.74e-04
Signaling by Insulin receptor 59 1.38e-04 5.83e-04 0.40000 0.271000 0.294000 3.14e-04 9.30e-05
EGFR downregulation 26 1.48e-04 6.24e-04 0.47500 0.148000 0.451000 1.90e-01 6.85e-05
Late endosomal microautophagy 29 1.52e-04 6.38e-04 0.56800 0.413000 0.390000 1.18e-04 2.81e-04
Integration of energy metabolism 86 1.53e-04 6.38e-04 0.31800 0.185000 0.259000 3.05e-03 3.34e-05
RNA Polymerase I Promoter Opening 19 1.59e-04 6.63e-04 0.61800 0.280000 0.551000 3.43e-02 3.22e-05
M Phase 359 1.68e-04 6.97e-04 0.16000 0.123000 0.103000 6.58e-05 7.98e-04
UCH proteinases 86 1.71e-04 7.08e-04 0.32800 0.222000 0.241000 3.70e-04 1.13e-04
Glycerophospholipid biosynthesis 106 1.72e-04 7.10e-04 0.29600 0.213000 0.205000 1.50e-04 2.67e-04
Oxidative Stress Induced Senescence 79 1.79e-04 7.36e-04 0.29800 0.130000 0.268000 4.59e-02 3.88e-05
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 1.79e-04 7.36e-04 0.24700 -0.031200 0.245000 6.94e-01 2.07e-03
Signaling by VEGF 97 1.87e-04 7.64e-04 0.25000 0.087300 0.234000 1.37e-01 6.63e-05
SARS-CoV Infections 140 2.03e-04 8.29e-04 0.23900 0.128000 0.202000 9.11e-03 3.80e-05
S Phase 160 2.05e-04 8.36e-04 0.14900 0.149000 -0.003830 1.14e-03 9.33e-01
Advanced glycosylation endproduct receptor signaling 12 2.06e-04 8.37e-04 0.84100 0.501000 0.676000 2.65e-03 5.01e-05
Transcriptional regulation of white adipocyte differentiation 77 2.08e-04 8.43e-04 0.26200 0.070500 0.252000 2.85e-01 1.30e-04
Pre-NOTCH Processing in Golgi 18 2.11e-04 8.52e-04 0.42000 -0.050600 0.417000 7.10e-01 2.20e-03
Transcriptional regulation of granulopoiesis 46 2.13e-04 8.57e-04 0.42800 0.253000 0.345000 2.96e-03 5.02e-05
Phospholipid metabolism 184 2.33e-04 9.30e-04 0.20600 0.109000 0.175000 1.05e-02 4.35e-05
Amino acids regulate mTORC1 50 2.33e-04 9.30e-04 0.41600 0.263000 0.323000 1.31e-03 7.82e-05
Costimulation by the CD28 family 74 2.41e-04 9.61e-04 0.33500 -0.196000 -0.271000 3.52e-03 5.52e-05
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 2.43e-04 9.64e-04 0.47700 0.276000 0.389000 4.18e-03 5.31e-05
Interleukin-12 signaling 44 2.54e-04 1.01e-03 0.41300 0.354000 0.213000 4.72e-05 1.47e-02
Degradation of the extracellular matrix 78 2.80e-04 1.11e-03 0.28600 0.118000 0.261000 7.11e-02 6.87e-05
tRNA processing in the mitochondrion 32 3.00e-04 1.18e-03 0.30600 -0.303000 0.041600 2.98e-03 6.84e-01
Platelet sensitization by LDL 16 3.03e-04 1.19e-03 0.66200 0.319000 0.580000 2.69e-02 5.85e-05
mTORC1-mediated signalling 24 3.24e-04 1.27e-03 0.59700 0.430000 0.414000 2.67e-04 4.40e-04
Sphingolipid metabolism 78 3.46e-04 1.35e-03 0.30300 0.154000 0.261000 1.90e-02 6.55e-05
Platelet Aggregation (Plug Formation) 28 3.46e-04 1.35e-03 0.48300 0.215000 0.432000 4.85e-02 7.44e-05
G2/M Checkpoints 138 3.55e-04 1.38e-03 0.20300 0.189000 0.071600 1.21e-04 1.47e-01
Mitochondrial biogenesis 88 3.60e-04 1.39e-03 0.31000 0.221000 0.217000 3.29e-04 4.22e-04
Signal transduction by L1 20 3.61e-04 1.40e-03 0.56500 0.246000 0.509000 5.72e-02 8.12e-05
Rho GTPase cycle 125 3.76e-04 1.45e-03 0.16400 -0.000755 0.164000 9.88e-01 1.50e-03
Collagen degradation 28 3.93e-04 1.51e-03 0.50300 0.256000 0.432000 1.88e-02 7.48e-05
Formation of ATP by chemiosmotic coupling 18 3.96e-04 1.52e-03 0.68000 0.466000 0.495000 6.13e-04 2.76e-04
TBC/RABGAPs 45 4.21e-04 1.61e-03 0.31400 0.067000 0.307000 4.37e-01 3.66e-04
Trafficking of GluR2-containing AMPA receptors 12 4.26e-04 1.62e-03 0.57700 0.081700 0.571000 6.24e-01 6.10e-04
Effects of PIP2 hydrolysis 24 4.50e-04 1.71e-03 0.50300 -0.457000 -0.212000 1.08e-04 7.23e-02
COPI-dependent Golgi-to-ER retrograde traffic 78 4.59e-04 1.74e-03 0.32400 0.224000 0.235000 6.32e-04 3.39e-04
Recycling pathway of L1 26 4.84e-04 1.83e-03 0.46600 0.178000 0.431000 1.17e-01 1.41e-04
Unwinding of DNA 12 4.92e-04 1.85e-03 0.80400 -0.492000 -0.635000 3.17e-03 1.38e-04
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 5.42e-04 2.04e-03 0.70200 0.331000 0.619000 3.86e-02 1.10e-04
PCNA-Dependent Long Patch Base Excision Repair 21 5.45e-04 2.04e-03 0.38800 0.006030 -0.388000 9.62e-01 2.08e-03
Fatty acid metabolism 150 5.50e-04 2.06e-03 0.23100 0.170000 0.156000 3.20e-04 9.61e-04
Lagging Strand Synthesis 20 5.76e-04 2.14e-03 0.41500 -0.025400 -0.415000 8.44e-01 1.33e-03
Uptake and function of anthrax toxins 10 5.79e-04 2.15e-03 0.86500 0.518000 0.693000 4.59e-03 1.47e-04
Senescence-Associated Secretory Phenotype (SASP) 66 5.90e-04 2.18e-03 0.31900 0.164000 0.274000 2.16e-02 1.15e-04
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 6.02e-04 2.22e-03 0.30800 0.107000 0.289000 1.69e-01 2.10e-04
Golgi Cisternae Pericentriolar Stack Reorganization 14 6.29e-04 2.32e-03 0.74900 0.519000 0.540000 7.78e-04 4.69e-04
Pyruvate metabolism and Citric Acid (TCA) cycle 52 6.38e-04 2.34e-03 0.38500 0.294000 0.248000 2.46e-04 1.96e-03
Regulation of TP53 Activity through Acetylation 29 6.70e-04 2.46e-03 0.41500 -0.392000 -0.137000 2.61e-04 2.02e-01
Platelet homeostasis 67 7.04e-04 2.57e-03 0.27600 0.096400 0.259000 1.72e-01 2.45e-04
Metabolism of steroids 116 7.26e-04 2.65e-03 0.23500 0.116000 0.204000 3.10e-02 1.45e-04
Generic Transcription Pathway 1078 7.38e-04 2.68e-03 0.08580 -0.055800 -0.065300 2.00e-03 2.98e-04
Opioid Signalling 75 7.49e-04 2.72e-03 0.30100 0.162000 0.253000 1.50e-02 1.52e-04
The NLRP3 inflammasome 15 7.59e-04 2.74e-03 0.68700 0.560000 0.398000 1.75e-04 7.62e-03
Estrogen-dependent gene expression 98 7.81e-04 2.82e-03 0.23300 0.089200 0.216000 1.27e-01 2.27e-04
Antigen processing: Ubiquitination & Proteasome degradation 286 7.83e-04 2.82e-03 0.16200 0.102000 0.126000 2.98e-03 2.60e-04
Interferon gamma signaling 83 7.98e-04 2.86e-03 0.21900 -0.043000 -0.215000 4.98e-01 7.15e-04
Processive synthesis on the lagging strand 15 8.16e-04 2.92e-03 0.43800 0.021300 -0.438000 8.86e-01 3.33e-03
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer’s disease models 20 8.61e-04 3.06e-03 0.59400 0.353000 0.478000 6.33e-03 2.15e-04
Neurodegenerative Diseases 20 8.61e-04 3.06e-03 0.59400 0.353000 0.478000 6.33e-03 2.15e-04
p130Cas linkage to MAPK signaling for integrins 11 8.77e-04 3.11e-03 0.82400 0.560000 0.605000 1.31e-03 5.14e-04
Packaging Of Telomere Ends 20 8.89e-04 3.15e-03 0.48100 0.148000 0.458000 2.53e-01 3.92e-04
Inhibition of DNA recombination at telomere 35 9.07e-04 3.20e-03 0.41000 0.189000 0.364000 5.29e-02 1.95e-04
Intra-Golgi traffic 43 9.12e-04 3.21e-03 0.31400 0.079100 0.304000 3.69e-01 5.64e-04
G2/M Transition 178 9.22e-04 3.24e-03 0.18400 0.162000 0.087600 1.92e-04 4.38e-02
MHC class II antigen presentation 101 9.23e-04 3.24e-03 0.25800 0.143000 0.214000 1.31e-02 1.96e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 9.59e-04 3.35e-03 0.39900 -0.075300 -0.392000 5.23e-01 8.80e-04
Cell recruitment (pro-inflammatory response) 22 9.65e-04 3.35e-03 0.53100 0.459000 0.267000 1.95e-04 3.02e-02
Purinergic signaling in leishmaniasis infection 22 9.65e-04 3.35e-03 0.53100 0.459000 0.267000 1.95e-04 3.02e-02
Signaling by EGFR 45 9.88e-04 3.42e-03 0.35200 0.153000 0.317000 7.52e-02 2.31e-04
Infection with Mycobacterium tuberculosis 26 9.89e-04 3.42e-03 0.53200 0.385000 0.367000 6.72e-04 1.19e-03
Energy dependent regulation of mTOR by LKB1-AMPK 27 1.04e-03 3.58e-03 0.51300 0.326000 0.397000 3.41e-03 3.54e-04
Selective autophagy 57 1.04e-03 3.58e-03 0.35800 0.264000 0.241000 5.67e-04 1.63e-03
Mitotic G2-G2/M phases 180 1.05e-03 3.59e-03 0.18500 0.160000 0.092900 2.12e-04 3.16e-02
Notch-HLH transcription pathway 28 1.08e-03 3.71e-03 0.40600 0.132000 0.384000 2.28e-01 4.30e-04
Telomere C-strand (Lagging Strand) Synthesis 34 1.14e-03 3.88e-03 0.34600 -0.085600 -0.336000 3.88e-01 7.08e-04
Negative regulation of MET activity 18 1.23e-03 4.19e-03 0.61200 0.368000 0.489000 6.88e-03 3.24e-04
Dissolution of Fibrin Clot 12 1.32e-03 4.50e-03 0.75600 0.479000 0.585000 4.08e-03 4.47e-04
Peptide hormone metabolism 49 1.33e-03 4.50e-03 0.28700 0.277000 0.072500 7.88e-04 3.80e-01
activated TAK1 mediates p38 MAPK activation 19 1.40e-03 4.72e-03 0.58400 0.338000 0.476000 1.07e-02 3.31e-04
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 1.42e-03 4.79e-03 0.47400 0.384000 0.277000 3.46e-04 9.72e-03
GPVI-mediated activation cascade 31 1.47e-03 4.95e-03 0.34100 0.064600 0.335000 5.33e-01 1.26e-03
TNFs bind their physiological receptors 25 1.50e-03 5.03e-03 0.28200 0.102000 -0.263000 3.76e-01 2.30e-02
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.51e-03 5.05e-03 0.22700 -0.108000 0.200000 2.61e-01 3.81e-02
Removal of the Flap Intermediate 14 1.54e-03 5.14e-03 0.41000 0.062400 -0.405000 6.86e-01 8.67e-03
Chaperonin-mediated protein folding 84 1.54e-03 5.14e-03 0.28500 0.186000 0.216000 3.20e-03 6.34e-04
Metabolism of non-coding RNA 53 1.56e-03 5.18e-03 0.19600 0.062000 -0.186000 4.35e-01 1.89e-02
snRNP Assembly 53 1.56e-03 5.18e-03 0.19600 0.062000 -0.186000 4.35e-01 1.89e-02
E3 ubiquitin ligases ubiquitinate target proteins 52 1.57e-03 5.21e-03 0.35500 0.216000 0.282000 7.15e-03 4.36e-04
Interleukin-10 signaling 35 1.62e-03 5.35e-03 0.36900 0.341000 0.140000 4.81e-04 1.52e-01
Integrin signaling 22 1.65e-03 5.43e-03 0.50600 0.249000 0.440000 4.34e-02 3.48e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.70e-03 5.57e-03 0.75200 0.540000 0.524000 1.20e-03 1.67e-03
Cytosolic tRNA aminoacylation 24 1.78e-03 5.85e-03 0.34200 0.341000 0.008680 3.79e-03 9.41e-01
WNT5A-dependent internalization of FZD4 13 1.81e-03 5.91e-03 0.54000 0.133000 0.523000 4.05e-01 1.09e-03
Prefoldin mediated transfer of substrate to CCT/TriC 26 1.82e-03 5.91e-03 0.48300 0.401000 0.270000 4.05e-04 1.71e-02
SARS-CoV-2 Infection 63 1.82e-03 5.91e-03 0.30900 0.169000 0.258000 2.03e-02 3.95e-04
Signal amplification 28 1.87e-03 6.05e-03 0.48800 0.334000 0.356000 2.22e-03 1.10e-03
Protein folding 90 1.90e-03 6.14e-03 0.26900 0.169000 0.209000 5.54e-03 6.22e-04
TCR signaling 121 1.97e-03 6.35e-03 0.18300 0.175000 0.054500 8.85e-04 3.00e-01
Signalling to ERKs 31 2.07e-03 6.66e-03 0.46100 0.322000 0.330000 1.92e-03 1.47e-03
Apoptotic factor-mediated response 18 2.13e-03 6.85e-03 0.56900 0.476000 0.310000 4.66e-04 2.27e-02
mRNA Splicing 187 2.22e-03 7.12e-03 0.17000 0.148000 0.084100 4.77e-04 4.75e-02
Resolution of Abasic Sites (AP sites) 37 2.25e-03 7.19e-03 0.34000 -0.118000 -0.319000 2.14e-01 7.81e-04
Nuclear Events (kinase and transcription factor activation) 53 2.26e-03 7.21e-03 0.33100 0.181000 0.276000 2.24e-02 4.98e-04
Homologous DNA Pairing and Strand Exchange 42 2.28e-03 7.27e-03 0.32000 -0.112000 -0.300000 2.09e-01 7.81e-04
tRNA processing in the nucleus 59 2.35e-03 7.48e-03 0.21300 -0.005320 -0.213000 9.44e-01 4.64e-03
Processing of Capped Intron-Containing Pre-mRNA 238 2.56e-03 8.10e-03 0.12700 0.122000 0.035600 1.24e-03 3.44e-01
Response of Mtb to phagocytosis 22 2.58e-03 8.15e-03 0.53700 0.378000 0.382000 2.12e-03 1.94e-03
GAB1 signalosome 14 2.64e-03 8.34e-03 0.50500 0.126000 0.489000 4.15e-01 1.52e-03
Fanconi Anemia Pathway 36 2.72e-03 8.55e-03 0.40000 -0.228000 -0.329000 1.80e-02 6.41e-04
Hyaluronan metabolism 15 2.73e-03 8.58e-03 0.59700 0.306000 0.512000 4.02e-02 5.91e-04
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.75e-03 8.62e-03 0.26400 -0.110000 0.240000 3.43e-01 3.77e-02
DNA methylation 20 2.76e-03 8.64e-03 0.44700 0.146000 0.423000 2.58e-01 1.06e-03
RHO GTPases Activate ROCKs 18 2.84e-03 8.87e-03 0.55200 0.297000 0.466000 2.93e-02 6.26e-04
tRNA modification in the nucleus and cytosol 43 3.08e-03 9.58e-03 0.20400 0.070100 -0.192000 4.27e-01 2.96e-02
Extension of Telomeres 51 3.11e-03 9.65e-03 0.24900 -0.045500 -0.245000 5.74e-01 2.50e-03
Cell Cycle Checkpoints 258 3.20e-03 9.92e-03 0.12100 0.116000 0.036800 1.37e-03 3.09e-01
Gene expression (Transcription) 1325 3.24e-03 1.00e-02 0.06600 -0.036000 -0.055300 2.78e-02 7.28e-04
Signaling by NOTCH1 66 3.25e-03 1.00e-02 0.28600 0.154000 0.241000 3.01e-02 7.25e-04
Signaling by Non-Receptor Tyrosine Kinases 47 3.38e-03 1.04e-02 0.32700 0.161000 0.284000 5.55e-02 7.49e-04
Signaling by PTK6 47 3.38e-03 1.04e-02 0.32700 0.161000 0.284000 5.55e-02 7.49e-04
DARPP-32 events 22 3.41e-03 1.04e-02 0.48600 0.253000 0.415000 3.97e-02 7.50e-04
Mitochondrial iron-sulfur cluster biogenesis 13 3.51e-03 1.07e-02 0.55600 0.520000 0.197000 1.18e-03 2.19e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 3.56e-03 1.09e-02 0.56700 0.512000 0.243000 9.04e-04 1.16e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 3.59e-03 1.09e-02 0.39500 0.223000 0.326000 2.24e-02 8.51e-04
Nucleobase biosynthesis 13 3.62e-03 1.10e-02 0.34900 0.176000 -0.302000 2.73e-01 5.94e-02
Calnexin/calreticulin cycle 26 3.70e-03 1.12e-02 0.46400 0.276000 0.373000 1.49e-02 9.82e-04
mRNA Splicing - Major Pathway 179 3.91e-03 1.18e-02 0.16500 0.144000 0.080900 8.79e-04 6.20e-02
Ion channel transport 133 3.91e-03 1.18e-02 0.19600 0.103000 0.167000 3.97e-02 8.72e-04
Cleavage of the damaged purine 24 4.05e-03 1.21e-02 0.38100 0.106000 0.366000 3.68e-01 1.93e-03
Depurination 24 4.05e-03 1.21e-02 0.38100 0.106000 0.366000 3.68e-01 1.93e-03
Recognition and association of DNA glycosylase with site containing an affected purine 24 4.05e-03 1.21e-02 0.38100 0.106000 0.366000 3.68e-01 1.93e-03
Termination of translesion DNA synthesis 32 4.09e-03 1.22e-02 0.22300 0.100000 -0.199000 3.26e-01 5.09e-02
XBP1(S) activates chaperone genes 47 4.51e-03 1.34e-02 0.32100 0.162000 0.277000 5.44e-02 1.01e-03
RAF activation 32 4.58e-03 1.36e-02 0.42300 0.291000 0.307000 4.36e-03 2.63e-03
tRNA processing 136 4.70e-03 1.39e-02 0.16000 -0.046700 -0.153000 3.47e-01 2.09e-03
Folding of actin by CCT/TriC 10 4.78e-03 1.42e-02 0.60300 0.570000 0.197000 1.81e-03 2.80e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 4.87e-03 1.44e-02 0.22600 -0.080400 0.211000 4.31e-01 3.86e-02
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 4.88e-03 1.44e-02 0.74300 0.471000 0.574000 9.91e-03 1.67e-03
IKK complex recruitment mediated by RIP1 23 5.00e-03 1.47e-02 0.49000 0.376000 0.314000 1.81e-03 9.07e-03
RORA activates gene expression 18 5.02e-03 1.47e-02 0.31600 -0.070800 0.308000 6.03e-01 2.36e-02
Activation of gene expression by SREBF (SREBP) 42 5.03e-03 1.47e-02 0.28500 0.083100 0.273000 3.51e-01 2.24e-03
Pentose phosphate pathway 13 5.13e-03 1.50e-02 0.65500 0.438000 0.487000 6.22e-03 2.38e-03
Interconversion of nucleotide di- and triphosphates 27 5.16e-03 1.51e-02 0.34300 0.332000 0.086300 2.79e-03 4.37e-01
CD28 dependent PI3K/Akt signaling 22 5.42e-03 1.58e-02 0.48100 -0.395000 -0.275000 1.34e-03 2.55e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 5.50e-03 1.60e-02 0.73000 0.573000 0.452000 1.70e-03 1.32e-02
Presynaptic phase of homologous DNA pairing and strand exchange 39 5.52e-03 1.60e-02 0.28700 -0.075800 -0.277000 4.13e-01 2.79e-03
Retrograde neurotrophin signalling 12 5.63e-03 1.63e-02 0.59200 0.260000 0.532000 1.19e-01 1.43e-03
Pyruvate metabolism 28 5.65e-03 1.63e-02 0.43900 0.337000 0.282000 2.05e-03 9.85e-03
Retrograde transport at the Trans-Golgi-Network 49 5.65e-03 1.63e-02 0.28500 0.115000 0.261000 1.64e-01 1.59e-03
Nucleobase catabolism 28 5.68e-03 1.63e-02 0.40100 0.351000 0.195000 1.32e-03 7.44e-02
RHO GTPases activate PAKs 20 5.94e-03 1.70e-02 0.44800 0.187000 0.407000 1.49e-01 1.61e-03
RNA Polymerase II Pre-transcription Events 78 5.95e-03 1.70e-02 0.24500 0.128000 0.210000 5.11e-02 1.37e-03
Gluconeogenesis 28 5.97e-03 1.71e-02 0.44200 0.315000 0.310000 3.93e-03 4.57e-03
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 5.98e-03 1.71e-02 0.26000 -0.003330 0.260000 9.74e-01 1.09e-02
PINK1-PRKN Mediated Mitophagy 21 6.01e-03 1.71e-02 0.41000 0.386000 0.138000 2.19e-03 2.73e-01
Interactions of Rev with host cellular proteins 37 6.24e-03 1.77e-02 0.29100 -0.077000 -0.281000 4.18e-01 3.13e-03
IRE1alpha activates chaperones 49 6.34e-03 1.80e-02 0.30600 0.157000 0.263000 5.77e-02 1.47e-03
Neurotransmitter receptors and postsynaptic signal transmission 123 6.53e-03 1.85e-02 0.19000 0.092700 0.165000 7.59e-02 1.53e-03
Glycosaminoglycan metabolism 92 6.76e-03 1.91e-02 0.17200 0.030100 0.169000 6.18e-01 5.10e-03
MET activates RAP1 and RAC1 10 6.88e-03 1.94e-02 0.66800 0.338000 0.576000 6.44e-02 1.60e-03
Signaling by Leptin 10 6.91e-03 1.94e-02 0.72800 0.523000 0.507000 4.21e-03 5.54e-03
Sealing of the nuclear envelope (NE) by ESCRT-III 25 6.91e-03 1.94e-02 0.43400 0.237000 0.364000 4.04e-02 1.65e-03
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 7.05e-03 1.97e-02 0.43700 0.280000 0.335000 1.17e-02 2.55e-03
Formation of RNA Pol II elongation complex 57 7.07e-03 1.97e-02 0.26200 0.111000 0.238000 1.48e-01 1.90e-03
RNA Polymerase II Transcription Elongation 57 7.07e-03 1.97e-02 0.26200 0.111000 0.238000 1.48e-01 1.90e-03
Plasma lipoprotein assembly, remodeling, and clearance 52 8.22e-03 2.29e-02 0.29700 0.165000 0.247000 3.95e-02 2.02e-03
MAPK targets/ Nuclear events mediated by MAP kinases 31 8.38e-03 2.33e-02 0.40100 0.257000 0.308000 1.34e-02 3.01e-03
Spry regulation of FGF signaling 16 8.44e-03 2.34e-02 0.53500 0.297000 0.444000 3.96e-02 2.08e-03
IRAK1 recruits IKK complex 10 8.50e-03 2.34e-02 0.65900 0.340000 0.564000 6.25e-02 2.02e-03
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 8.50e-03 2.34e-02 0.65900 0.340000 0.564000 6.25e-02 2.02e-03
Signaling by SCF-KIT 40 8.51e-03 2.34e-02 0.35300 0.270000 0.227000 3.11e-03 1.31e-02
RNA polymerase II transcribes snRNA genes 72 8.53e-03 2.35e-02 0.25300 0.142000 0.209000 3.76e-02 2.13e-03
PIWI-interacting RNA (piRNA) biogenesis 24 8.71e-03 2.39e-02 0.29100 0.291000 -0.000729 1.37e-02 9.95e-01
rRNA processing in the mitochondrion 29 9.05e-03 2.48e-02 0.29300 -0.289000 -0.046200 7.09e-03 6.67e-01
NR1H2 and NR1H3-mediated signaling 38 9.32e-03 2.55e-02 0.19900 -0.057800 0.191000 5.38e-01 4.21e-02
PKMTs methylate histone lysines 44 9.46e-03 2.58e-02 0.21400 -0.214000 -0.001080 1.41e-02 9.90e-01
Processing of SMDT1 15 9.49e-03 2.58e-02 0.40000 0.396000 0.056800 7.92e-03 7.03e-01
Purine ribonucleoside monophosphate biosynthesis 10 9.57e-03 2.60e-02 0.35400 0.270000 -0.229000 1.39e-01 2.11e-01
Metabolism of Angiotensinogen to Angiotensins 11 9.60e-03 2.60e-02 0.55500 0.515000 0.205000 3.09e-03 2.38e-01
HDR through Homologous Recombination (HRR) 66 9.87e-03 2.67e-02 0.20300 -0.047800 -0.198000 5.02e-01 5.47e-03
VLDLR internalisation and degradation 11 9.92e-03 2.68e-02 0.53200 0.171000 0.503000 3.26e-01 3.83e-03
Vpr-mediated nuclear import of PICs 34 9.98e-03 2.69e-02 0.28000 -0.062700 -0.273000 5.27e-01 5.81e-03
RHO GTPases activate IQGAPs 11 1.03e-02 2.77e-02 0.59800 0.285000 0.526000 1.02e-01 2.54e-03
Cytochrome c-mediated apoptotic response 13 1.06e-02 2.86e-02 0.60000 0.467000 0.376000 3.52e-03 1.89e-02
Platelet calcium homeostasis 21 1.08e-02 2.90e-02 0.24100 -0.155000 0.185000 2.19e-01 1.43e-01
Sphingolipid de novo biosynthesis 42 1.09e-02 2.90e-02 0.33000 0.200000 0.263000 2.51e-02 3.20e-03
Growth hormone receptor signaling 20 1.10e-02 2.94e-02 0.48700 0.366000 0.322000 4.61e-03 1.27e-02
Diseases associated with O-glycosylation of proteins 47 1.11e-02 2.95e-02 0.31000 -0.249000 -0.184000 3.13e-03 2.87e-02
Interactions of Vpr with host cellular proteins 37 1.12e-02 2.98e-02 0.26900 -0.064500 -0.261000 4.97e-01 6.04e-03
ATF6 (ATF6-alpha) activates chaperone genes 10 1.12e-02 2.98e-02 0.62600 0.546000 0.306000 2.76e-03 9.36e-02
Regulation of insulin secretion 60 1.13e-02 2.98e-02 0.28100 0.186000 0.210000 1.26e-02 4.81e-03
ERK/MAPK targets 22 1.17e-02 3.09e-02 0.45300 0.277000 0.359000 2.46e-02 3.55e-03
Transport of bile salts and organic acids, metal ions and amine compounds 55 1.17e-02 3.09e-02 0.28200 0.163000 0.230000 3.60e-02 3.15e-03
Factors involved in megakaryocyte development and platelet production 116 1.22e-02 3.20e-02 0.18600 0.094800 0.160000 7.78e-02 2.98e-03
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 1.22e-02 3.20e-02 0.35800 0.274000 0.230000 4.51e-03 1.68e-02
p75 NTR receptor-mediated signalling 88 1.23e-02 3.21e-02 0.21300 0.110000 0.183000 7.50e-02 3.01e-03
Regulation of IFNG signaling 14 1.23e-02 3.22e-02 0.57800 0.401000 0.417000 9.41e-03 6.92e-03
Nucleotide salvage 21 1.29e-02 3.36e-02 0.45800 0.365000 0.277000 3.81e-03 2.82e-02
Nuclear import of Rev protein 34 1.30e-02 3.37e-02 0.28800 -0.085200 -0.275000 3.90e-01 5.52e-03
Rev-mediated nuclear export of HIV RNA 35 1.30e-02 3.37e-02 0.29100 -0.096000 -0.275000 3.26e-01 4.87e-03
Butyrophilin (BTN) family interactions 10 1.31e-02 3.41e-02 0.63500 -0.339000 -0.537000 6.38e-02 3.27e-03
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 1.33e-02 3.44e-02 0.21000 0.194000 0.080700 4.14e-03 2.33e-01
Cell Cycle, Mitotic 500 1.33e-02 3.44e-02 0.08050 0.074600 0.030200 4.27e-03 2.48e-01
Signaling by TGF-beta Receptor Complex 72 1.34e-02 3.46e-02 0.18900 0.044900 0.183000 5.10e-01 7.17e-03
Unfolded Protein Response (UPR) 87 1.35e-02 3.47e-02 0.23000 0.164000 0.161000 8.20e-03 9.27e-03
Semaphorin interactions 57 1.38e-02 3.55e-02 0.26000 0.132000 0.224000 8.37e-02 3.43e-03
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 1.44e-02 3.69e-02 0.54900 0.397000 0.379000 7.83e-03 1.10e-02
Regulation of PTEN gene transcription 59 1.45e-02 3.73e-02 0.23800 0.101000 0.216000 1.81e-01 4.10e-03
Citric acid cycle (TCA cycle) 22 1.46e-02 3.73e-02 0.45200 0.314000 0.326000 1.08e-02 8.14e-03
Elevation of cytosolic Ca2+ levels 12 1.46e-02 3.73e-02 0.30900 -0.242000 0.192000 1.47e-01 2.49e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 1.49e-02 3.81e-02 0.60900 0.450000 0.410000 6.95e-03 1.38e-02
Mitochondrial calcium ion transport 22 1.50e-02 3.82e-02 0.34700 0.333000 0.097400 6.77e-03 4.29e-01
Phase 0 - rapid depolarisation 22 1.55e-02 3.94e-02 0.43800 -0.348000 -0.265000 4.66e-03 3.16e-02
Activation of Matrix Metalloproteinases 23 1.56e-02 3.95e-02 0.43800 0.298000 0.321000 1.34e-02 7.61e-03
Cell Cycle 622 1.57e-02 3.97e-02 0.06130 0.060300 0.011200 1.03e-02 6.32e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 1.61e-02 4.06e-02 0.16700 -0.056500 0.157000 5.07e-01 6.49e-02
InlB-mediated entry of Listeria monocytogenes into host cell 12 1.65e-02 4.16e-02 0.60200 0.409000 0.442000 1.42e-02 7.99e-03
Chaperone Mediated Autophagy 19 1.65e-02 4.16e-02 0.40700 0.372000 0.163000 4.96e-03 2.17e-01
Transmission across Chemical Synapses 170 1.69e-02 4.23e-02 0.16000 0.105000 0.120000 1.79e-02 6.97e-03
Diseases of carbohydrate metabolism 29 1.70e-02 4.25e-02 0.38600 0.260000 0.286000 1.55e-02 7.78e-03
PLC beta mediated events 43 1.73e-02 4.33e-02 0.26800 0.107000 0.246000 2.26e-01 5.26e-03
ADP signalling through P2Y purinoceptor 1 21 1.75e-02 4.38e-02 0.45300 0.329000 0.311000 9.04e-03 1.37e-02
HIV Life Cycle 144 1.76e-02 4.38e-02 0.16700 0.136000 0.097200 4.92e-03 4.41e-02
N-glycan antennae elongation in the medial/trans-Golgi 21 1.77e-02 4.40e-02 0.27300 -0.272000 0.023600 3.08e-02 8.51e-01
G1/S-Specific Transcription 29 1.78e-02 4.42e-02 0.19400 0.120000 -0.152000 2.62e-01 1.56e-01
Gap junction trafficking 13 1.78e-02 4.42e-02 0.51800 0.250000 0.454000 1.18e-01 4.61e-03
Cleavage of the damaged pyrimidine 29 1.79e-02 4.42e-02 0.29100 0.074900 0.281000 4.85e-01 8.76e-03
Depyrimidination 29 1.79e-02 4.42e-02 0.29100 0.074900 0.281000 4.85e-01 8.76e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 1.79e-02 4.42e-02 0.29100 0.074900 0.281000 4.85e-01 8.76e-03
DNA Double Strand Break Response 47 1.83e-02 4.50e-02 0.16100 -0.059400 0.150000 4.81e-01 7.58e-02
Late Phase of HIV Life Cycle 131 1.85e-02 4.51e-02 0.18000 0.134000 0.120000 8.17e-03 1.75e-02
PI Metabolism 79 1.85e-02 4.51e-02 0.13200 -0.028000 0.129000 6.67e-01 4.76e-02
VxPx cargo-targeting to cilium 19 1.86e-02 4.51e-02 0.38500 0.135000 0.361000 3.07e-01 6.50e-03
Signaling by TGFB family members 91 1.87e-02 4.51e-02 0.19200 0.089300 0.170000 1.41e-01 4.96e-03
Apoptotic execution phase 45 1.87e-02 4.51e-02 0.27700 0.134000 0.243000 1.20e-01 4.85e-03
LDL clearance 17 1.87e-02 4.51e-02 0.49300 0.316000 0.379000 2.40e-02 6.82e-03
Circadian Clock 67 1.87e-02 4.51e-02 0.16700 0.012300 0.167000 8.62e-01 1.82e-02
Activation of G protein gated Potassium channels 20 1.88e-02 4.51e-02 0.39700 0.359000 0.168000 5.40e-03 1.94e-01
G protein gated Potassium channels 20 1.88e-02 4.51e-02 0.39700 0.359000 0.168000 5.40e-03 1.94e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 1.88e-02 4.51e-02 0.39700 0.359000 0.168000 5.40e-03 1.94e-01
HIV Transcription Initiation 45 1.89e-02 4.51e-02 0.30400 0.196000 0.232000 2.31e-02 7.04e-03
RNA Polymerase II HIV Promoter Escape 45 1.89e-02 4.51e-02 0.30400 0.196000 0.232000 2.31e-02 7.04e-03
RNA Polymerase II Promoter Escape 45 1.89e-02 4.51e-02 0.30400 0.196000 0.232000 2.31e-02 7.04e-03
RNA Polymerase II Transcription Initiation 45 1.89e-02 4.51e-02 0.30400 0.196000 0.232000 2.31e-02 7.04e-03
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.89e-02 4.51e-02 0.30400 0.196000 0.232000 2.31e-02 7.04e-03
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.89e-02 4.51e-02 0.30400 0.196000 0.232000 2.31e-02 7.04e-03
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.91e-02 4.56e-02 0.46000 0.394000 0.237000 4.90e-03 9.05e-02
NS1 Mediated Effects on Host Pathways 40 1.92e-02 4.58e-02 0.29200 -0.139000 -0.256000 1.27e-01 5.03e-03
Formation of the beta-catenin:TCF transactivating complex 46 1.93e-02 4.60e-02 0.19500 0.004610 0.195000 9.57e-01 2.24e-02
G-protein beta:gamma signalling 29 1.95e-02 4.62e-02 0.34800 0.175000 0.301000 1.03e-01 5.01e-03
SHC1 events in EGFR signaling 11 1.95e-02 4.62e-02 0.59300 0.343000 0.484000 4.85e-02 5.45e-03
RIPK1-mediated regulated necrosis 29 1.97e-02 4.64e-02 0.30500 0.288000 0.102000 7.34e-03 3.44e-01
Regulated Necrosis 29 1.97e-02 4.64e-02 0.30500 0.288000 0.102000 7.34e-03 3.44e-01
Regulation of necroptotic cell death 29 1.97e-02 4.64e-02 0.30500 0.288000 0.102000 7.34e-03 3.44e-01
Signaling by ERBB4 44 1.98e-02 4.67e-02 0.30800 0.213000 0.223000 1.45e-02 1.06e-02
Chemokine receptors bind chemokines 39 2.01e-02 4.72e-02 0.27200 -0.103000 -0.252000 2.67e-01 6.52e-03
Adaptive Immune System 753 2.04e-02 4.78e-02 0.06830 0.059700 0.033300 5.32e-03 1.20e-01
NoRC negatively regulates rRNA expression 59 2.08e-02 4.88e-02 0.24400 0.125000 0.209000 9.64e-02 5.39e-03
ATF6 (ATF6-alpha) activates chaperones 12 2.09e-02 4.88e-02 0.56900 0.456000 0.341000 6.24e-03 4.10e-02
Signaling by WNT in cancer 30 2.09e-02 4.88e-02 0.18800 -0.152000 0.111000 1.51e-01 2.94e-01
Glycosphingolipid metabolism 36 2.09e-02 4.88e-02 0.27700 0.099200 0.259000 3.03e-01 7.22e-03
SUMOylation of transcription cofactors 44 2.14e-02 4.97e-02 0.15300 -0.115000 0.102000 1.87e-01 2.43e-01
HCMV Infection 96 2.17e-02 5.04e-02 0.19900 0.116000 0.162000 4.94e-02 6.20e-03
Diseases associated with glycosylation precursor biosynthesis 18 2.19e-02 5.07e-02 0.44900 0.375000 0.246000 5.82e-03 7.04e-02
Mitophagy 28 2.20e-02 5.08e-02 0.34300 0.301000 0.164000 5.83e-03 1.33e-01
Prolonged ERK activation events 13 2.21e-02 5.10e-02 0.50300 0.241000 0.441000 1.33e-01 5.85e-03
NEP/NS2 Interacts with the Cellular Export Machinery 32 2.27e-02 5.23e-02 0.26400 -0.061600 -0.257000 5.47e-01 1.20e-02
Assembly Of The HIV Virion 15 2.27e-02 5.23e-02 0.51900 0.365000 0.368000 1.43e-02 1.36e-02
Extra-nuclear estrogen signaling 65 2.29e-02 5.27e-02 0.24900 0.173000 0.179000 1.59e-02 1.25e-02
Signaling by FGFR in disease 50 2.30e-02 5.28e-02 0.26600 0.224000 0.142000 6.07e-03 8.16e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 2.31e-02 5.28e-02 0.29500 0.179000 0.234000 3.98e-02 7.18e-03
SARS-CoV-1 Infection 47 2.33e-02 5.33e-02 0.26500 0.131000 0.231000 1.21e-01 6.15e-03
Base-Excision Repair, AP Site Formation 31 2.38e-02 5.45e-02 0.26800 0.065000 0.260000 5.31e-01 1.22e-02
Formation of apoptosome 11 2.41e-02 5.48e-02 0.60000 0.438000 0.410000 1.19e-02 1.86e-02
Regulation of the apoptosome activity 11 2.41e-02 5.48e-02 0.60000 0.438000 0.410000 1.19e-02 1.86e-02
Muscle contraction 135 2.43e-02 5.52e-02 0.14800 0.062700 0.134000 2.09e-01 7.11e-03
G-protein mediated events 44 2.45e-02 5.56e-02 0.25000 0.095000 0.231000 2.75e-01 7.98e-03
ER Quality Control Compartment (ERQC) 21 2.50e-02 5.67e-02 0.42200 0.257000 0.335000 4.18e-02 7.87e-03
TP53 Regulates Transcription of Cell Death Genes 43 2.52e-02 5.68e-02 0.22100 0.216000 0.046200 1.44e-02 6.00e-01
Sema4D in semaphorin signaling 22 2.53e-02 5.68e-02 0.31300 0.072500 0.305000 5.56e-01 1.34e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 2.54e-02 5.68e-02 0.26800 0.169000 0.208000 3.33e-02 8.85e-03
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 2.54e-02 5.68e-02 0.26800 0.169000 0.208000 3.33e-02 8.85e-03
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 2.54e-02 5.68e-02 0.26800 0.169000 0.208000 3.33e-02 8.85e-03
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 2.54e-02 5.68e-02 0.26800 0.169000 0.208000 3.33e-02 8.85e-03
Signaling by NOTCH1 in Cancer 53 2.54e-02 5.68e-02 0.26800 0.169000 0.208000 3.33e-02 8.85e-03
N-Glycan antennae elongation 13 2.55e-02 5.71e-02 0.33500 -0.334000 0.021700 3.68e-02 8.92e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.58e-02 5.75e-02 0.41900 0.279000 0.313000 2.34e-02 1.12e-02
Biological oxidations 132 2.60e-02 5.78e-02 0.16200 0.136000 0.087600 6.98e-03 8.21e-02
Formation of tubulin folding intermediates by CCT/TriC 22 2.62e-02 5.82e-02 0.39700 0.332000 0.218000 7.10e-03 7.67e-02
SUMOylation of intracellular receptors 25 2.69e-02 5.98e-02 0.24300 -0.009510 0.243000 9.34e-01 3.53e-02
Incretin synthesis, secretion, and inactivation 10 2.71e-02 6.00e-02 0.44100 0.435000 0.077200 1.73e-02 6.73e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 2.71e-02 6.00e-02 0.44100 0.435000 0.077200 1.73e-02 6.73e-01
MASTL Facilitates Mitotic Progression 10 2.74e-02 6.04e-02 0.49300 0.467000 0.160000 1.06e-02 3.81e-01
Peroxisomal protein import 57 2.77e-02 6.12e-02 0.25500 0.199000 0.159000 9.48e-03 3.73e-02
O-glycosylation of TSR domain-containing proteins 25 2.79e-02 6.14e-02 0.39000 -0.267000 -0.285000 2.10e-02 1.37e-02
GRB2 events in EGFR signaling 10 2.82e-02 6.20e-02 0.59400 0.346000 0.483000 5.84e-02 8.22e-03
DNA Damage/Telomere Stress Induced Senescence 44 2.82e-02 6.20e-02 0.21100 0.039700 0.208000 6.48e-01 1.72e-02
Signal regulatory protein family interactions 12 2.83e-02 6.21e-02 0.56200 0.390000 0.405000 1.93e-02 1.51e-02
AKT phosphorylates targets in the cytosol 14 2.84e-02 6.22e-02 0.41500 0.135000 0.393000 3.81e-01 1.09e-02
Formation of Fibrin Clot (Clotting Cascade) 26 2.86e-02 6.24e-02 0.37700 0.240000 0.290000 3.38e-02 1.04e-02
Intrinsic Pathway for Apoptosis 53 3.00e-02 6.54e-02 0.24500 0.210000 0.126000 8.08e-03 1.14e-01
tRNA Aminoacylation 42 3.03e-02 6.59e-02 0.15100 0.124000 -0.086900 1.65e-01 3.30e-01
Glutathione conjugation 26 3.03e-02 6.59e-02 0.34800 0.300000 0.177000 8.19e-03 1.18e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 3.06e-02 6.65e-02 0.29300 0.168000 0.239000 6.52e-02 8.87e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 3.08e-02 6.66e-02 0.28500 -0.105000 -0.265000 3.13e-01 1.05e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 3.08e-02 6.66e-02 0.28500 -0.105000 -0.265000 3.13e-01 1.05e-02
Scavenging by Class A Receptors 11 3.11e-02 6.71e-02 0.47900 0.177000 0.445000 3.09e-01 1.06e-02
Gap-filling DNA repair synthesis and ligation in GG-NER 25 3.11e-02 6.71e-02 0.23000 0.024400 -0.229000 8.33e-01 4.78e-02
Caspase activation via extrinsic apoptotic signalling pathway 25 3.13e-02 6.75e-02 0.37100 0.300000 0.218000 9.36e-03 5.93e-02
Antiviral mechanism by IFN-stimulated genes 80 3.14e-02 6.76e-02 0.18400 -0.075600 -0.167000 2.42e-01 9.65e-03
Signaling by FGFR3 31 3.15e-02 6.77e-02 0.34500 0.239000 0.249000 2.15e-02 1.65e-02
Collagen formation 64 3.21e-02 6.89e-02 0.16200 0.016400 0.161000 8.21e-01 2.58e-02
Synthesis of PIPs at the plasma membrane 52 3.25e-02 6.95e-02 0.15300 -0.026900 0.151000 7.38e-01 5.99e-02
RNA Polymerase II Transcription 1197 3.31e-02 7.06e-02 0.05580 -0.035100 -0.043400 4.11e-02 1.16e-02
Signaling by FGFR4 31 3.31e-02 7.07e-02 0.34200 0.250000 0.233000 1.59e-02 2.48e-02
Transport of the SLBP Dependant Mature mRNA 36 3.33e-02 7.08e-02 0.20000 0.003040 -0.200000 9.75e-01 3.82e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 3.36e-02 7.15e-02 0.15500 0.119000 -0.099700 2.04e-01 2.88e-01
PERK regulates gene expression 31 3.38e-02 7.17e-02 0.22100 0.220000 0.006650 3.36e-02 9.49e-01
Transport of the SLBP independent Mature mRNA 35 3.38e-02 7.17e-02 0.21700 -0.022100 -0.216000 8.21e-01 2.68e-02
Export of Viral Ribonucleoproteins from Nucleus 33 3.39e-02 7.17e-02 0.23100 -0.034600 -0.229000 7.31e-01 2.30e-02
Ion transport by P-type ATPases 43 3.41e-02 7.20e-02 0.15600 -0.146000 0.054700 9.83e-02 5.35e-01
Formation of TC-NER Pre-Incision Complex 53 3.44e-02 7.26e-02 0.25400 0.155000 0.202000 5.14e-02 1.11e-02
Glycogen metabolism 23 3.50e-02 7.36e-02 0.38500 0.234000 0.305000 5.21e-02 1.13e-02
Signaling by Erythropoietin 24 3.53e-02 7.42e-02 0.34900 0.170000 0.305000 1.50e-01 9.79e-03
Neuronal System 253 3.56e-02 7.47e-02 0.11300 0.062500 0.094000 8.68e-02 1.01e-02
MET promotes cell motility 26 3.65e-02 7.66e-02 0.32000 0.139000 0.289000 2.19e-01 1.09e-02
Transport of Ribonucleoproteins into the Host Nucleus 32 3.66e-02 7.67e-02 0.26700 -0.089600 -0.252000 3.81e-01 1.38e-02
RNA Polymerase I Promoter Escape 44 3.77e-02 7.87e-02 0.27900 0.180000 0.213000 3.92e-02 1.43e-02
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 3.78e-02 7.87e-02 0.32800 0.110000 0.309000 3.83e-01 1.43e-02
Common Pathway of Fibrin Clot Formation 14 3.78e-02 7.87e-02 0.46200 0.239000 0.395000 1.21e-01 1.05e-02
Glucose metabolism 83 3.81e-02 7.94e-02 0.20300 0.155000 0.132000 1.48e-02 3.80e-02
Thromboxane signalling through TP receptor 20 3.83e-02 7.96e-02 0.41200 0.317000 0.263000 1.42e-02 4.17e-02
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.89e-02 8.07e-02 0.45000 0.220000 0.393000 1.54e-01 1.09e-02
G alpha (q) signalling events 132 3.91e-02 8.11e-02 0.08950 -0.025000 0.085900 6.19e-01 8.82e-02
Negative regulation of FGFR1 signaling 24 3.93e-02 8.14e-02 0.36300 0.207000 0.298000 7.93e-02 1.16e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 3.95e-02 8.15e-02 0.46500 0.202000 0.419000 2.26e-01 1.19e-02
Diseases of hemostasis 12 3.95e-02 8.15e-02 0.46500 0.202000 0.419000 2.26e-01 1.19e-02
G beta:gamma signalling through CDC42 17 4.03e-02 8.29e-02 0.43800 0.347000 0.268000 1.33e-02 5.55e-02
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 4.03e-02 8.29e-02 0.50800 0.251000 0.441000 1.49e-01 1.13e-02
Signaling by EGFR in Cancer 22 4.04e-02 8.29e-02 0.39100 0.256000 0.296000 3.77e-02 1.62e-02
Plasma lipoprotein clearance 28 4.08e-02 8.36e-02 0.33900 0.203000 0.271000 6.27e-02 1.29e-02
Platelet Adhesion to exposed collagen 13 4.11e-02 8.42e-02 0.50200 0.313000 0.392000 5.04e-02 1.43e-02
Caspase activation via Death Receptors in the presence of ligand 16 4.15e-02 8.49e-02 0.35500 0.341000 0.101000 1.83e-02 4.86e-01
Meiotic synapsis 45 4.21e-02 8.58e-02 0.20100 0.043100 0.196000 6.17e-01 2.28e-02
DNA Damage Bypass 47 4.21e-02 8.59e-02 0.13700 0.115000 -0.074600 1.74e-01 3.76e-01
Potential therapeutics for SARS 78 4.23e-02 8.60e-02 0.19300 0.101000 0.165000 1.21e-01 1.19e-02
Collagen biosynthesis and modifying enzymes 46 4.24e-02 8.60e-02 0.14800 -0.045600 0.141000 5.92e-01 9.90e-02
ADP signalling through P2Y purinoceptor 12 18 4.24e-02 8.61e-02 0.43100 0.318000 0.292000 1.96e-02 3.20e-02
Activation of the AP-1 family of transcription factors 10 4.28e-02 8.67e-02 0.57500 0.435000 0.377000 1.73e-02 3.92e-02
Erythropoietin activates RAS 13 4.31e-02 8.72e-02 0.50700 0.346000 0.371000 3.10e-02 2.07e-02
Signaling by FGFR1 in disease 30 4.32e-02 8.72e-02 0.32400 0.260000 0.194000 1.37e-02 6.61e-02
Recognition of DNA damage by PCNA-containing replication complex 30 4.35e-02 8.77e-02 0.17500 0.076500 -0.157000 4.68e-01 1.37e-01
Constitutive Signaling by AKT1 E17K in Cancer 26 4.36e-02 8.78e-02 0.18100 -0.109000 0.145000 3.36e-01 2.02e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 4.43e-02 8.91e-02 0.33800 0.198000 0.274000 7.46e-02 1.36e-02
GABA receptor activation 36 4.44e-02 8.91e-02 0.29800 0.234000 0.184000 1.51e-02 5.64e-02
Integrin cell surface interactions 52 4.51e-02 9.05e-02 0.23200 0.118000 0.200000 1.42e-01 1.28e-02
Oncogene Induced Senescence 33 4.55e-02 9.11e-02 0.23000 0.047900 0.225000 6.34e-01 2.50e-02
Signaling by FGFR2 60 4.59e-02 9.17e-02 0.22100 0.185000 0.121000 1.33e-02 1.06e-01
Negative regulation of FGFR3 signaling 20 4.60e-02 9.18e-02 0.40000 0.255000 0.308000 4.83e-02 1.71e-02
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 4.67e-02 9.31e-02 0.44100 0.268000 0.350000 6.30e-02 1.55e-02
Leading Strand Synthesis 14 4.72e-02 9.39e-02 0.29300 0.021200 -0.293000 8.91e-01 5.80e-02
Polymerase switching 14 4.72e-02 9.39e-02 0.29300 0.021200 -0.293000 8.91e-01 5.80e-02
Beta-catenin phosphorylation cascade 17 4.81e-02 9.55e-02 0.36400 0.139000 0.336000 3.21e-01 1.64e-02
Syndecan interactions 19 4.85e-02 9.61e-02 0.40000 0.321000 0.238000 1.55e-02 7.22e-02
TP53 Regulates Transcription of Cell Cycle Genes 47 4.86e-02 9.61e-02 0.15500 0.154000 -0.018800 6.73e-02 8.23e-01
Transcriptional Regulation by TP53 351 4.86e-02 9.61e-02 0.09480 0.074200 0.059000 1.70e-02 5.76e-02
Glucagon signaling in metabolic regulation 27 4.87e-02 9.61e-02 0.33700 0.206000 0.267000 6.41e-02 1.63e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 4.89e-02 9.63e-02 0.46200 0.408000 0.217000 1.43e-02 1.93e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 4.91e-02 9.65e-02 0.28600 0.273000 0.085400 2.07e-02 4.69e-01
HCMV Late Events 69 4.91e-02 9.65e-02 0.21200 0.131000 0.166000 5.92e-02 1.70e-02
Transcription of the HIV genome 67 4.93e-02 9.67e-02 0.20800 0.116000 0.173000 1.01e-01 1.46e-02
Condensation of Prophase Chromosomes 29 4.96e-02 9.70e-02 0.29700 0.139000 0.262000 1.94e-01 1.46e-02
Death Receptor Signalling 131 5.02e-02 9.80e-02 0.15600 0.113000 0.107000 2.50e-02 3.36e-02
Membrane binding and targetting of GAG proteins 13 5.03e-02 9.80e-02 0.49500 0.359000 0.340000 2.49e-02 3.39e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 5.03e-02 9.80e-02 0.49500 0.359000 0.340000 2.49e-02 3.39e-02
TNFR1-induced proapoptotic signaling 12 5.05e-02 9.83e-02 0.41600 -0.142000 -0.391000 3.94e-01 1.90e-02
RHO GTPases activate KTN1 11 5.06e-02 9.85e-02 0.53700 0.368000 0.391000 3.48e-02 2.46e-02
Interleukin-6 signaling 10 5.19e-02 1.01e-01 0.55800 0.420000 0.368000 2.16e-02 4.41e-02
NOD1/2 Signaling Pathway 32 5.28e-02 1.02e-01 0.30900 0.239000 0.195000 1.93e-02 5.57e-02
Defective B3GALTL causes Peters-plus syndrome (PpS) 24 5.28e-02 1.02e-01 0.36100 -0.248000 -0.263000 3.56e-02 2.60e-02
Synthesis of PC 23 5.41e-02 1.05e-01 0.36100 0.282000 0.225000 1.91e-02 6.18e-02
RHO GTPases activate CIT 18 5.43e-02 1.05e-01 0.34200 0.125000 0.318000 3.60e-01 1.94e-02
Glycogen synthesis 13 5.44e-02 1.05e-01 0.48800 0.340000 0.351000 3.39e-02 2.85e-02
Formation of the Early Elongation Complex 33 5.78e-02 1.11e-01 0.28200 0.148000 0.240000 1.41e-01 1.70e-02
Formation of the HIV-1 Early Elongation Complex 33 5.78e-02 1.11e-01 0.28200 0.148000 0.240000 1.41e-01 1.70e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 5.80e-02 1.11e-01 0.31500 0.313000 -0.031900 7.21e-02 8.55e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 5.83e-02 1.12e-01 0.22400 0.092500 0.204000 2.89e-01 1.90e-02
Alpha-protein kinase 1 signaling pathway 11 5.94e-02 1.14e-01 0.51300 0.402000 0.318000 2.08e-02 6.81e-02
Aquaporin-mediated transport 38 5.95e-02 1.14e-01 0.28100 0.194000 0.204000 3.89e-02 2.96e-02
Inwardly rectifying K+ channels 24 5.97e-02 1.14e-01 0.30900 0.278000 0.136000 1.86e-02 2.47e-01
Uptake and actions of bacterial toxins 27 6.00e-02 1.14e-01 0.33100 0.250000 0.217000 2.47e-02 5.07e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 6.04e-02 1.15e-01 0.43200 0.316000 0.294000 2.87e-02 4.16e-02
HATs acetylate histones 93 6.04e-02 1.15e-01 0.10200 -0.099400 0.022100 9.77e-02 7.13e-01
Metabolism of porphyrins 22 6.05e-02 1.15e-01 0.35000 0.196000 0.290000 1.11e-01 1.84e-02
Negative epigenetic regulation of rRNA expression 62 6.08e-02 1.15e-01 0.19900 0.097900 0.174000 1.83e-01 1.80e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 6.08e-02 1.15e-01 0.31400 0.173000 0.262000 1.20e-01 1.83e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 6.08e-02 1.15e-01 0.31400 0.173000 0.262000 1.20e-01 1.83e-02
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 6.18e-02 1.16e-01 0.38500 0.320000 0.214000 1.88e-02 1.15e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 6.18e-02 1.16e-01 0.38500 0.320000 0.214000 1.88e-02 1.15e-01
FGFR1 mutant receptor activation 23 6.22e-02 1.17e-01 0.35800 0.264000 0.241000 2.84e-02 4.50e-02
Synthesis of substrates in N-glycan biosythesis 58 6.25e-02 1.17e-01 0.20100 0.178000 0.093800 1.90e-02 2.17e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 6.26e-02 1.17e-01 0.28900 0.162000 0.239000 1.13e-01 1.91e-02
AKT phosphorylates targets in the nucleus 10 6.38e-02 1.20e-01 0.39900 -0.389000 -0.088100 3.32e-02 6.29e-01
Suppression of phagosomal maturation 12 6.39e-02 1.20e-01 0.49100 0.321000 0.371000 5.40e-02 2.62e-02
Myogenesis 21 6.49e-02 1.21e-01 0.32600 0.144000 0.292000 2.53e-01 2.04e-02
Triglyceride catabolism 16 6.49e-02 1.21e-01 0.41100 0.238000 0.334000 9.86e-02 2.06e-02
HDR through Single Strand Annealing (SSA) 37 6.49e-02 1.21e-01 0.22700 -0.077300 -0.213000 4.16e-01 2.48e-02
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 6.50e-02 1.21e-01 0.23000 0.102000 0.207000 2.53e-01 2.04e-02
HIV Transcription Elongation 42 6.50e-02 1.21e-01 0.23000 0.102000 0.207000 2.53e-01 2.04e-02
Tat-mediated elongation of the HIV-1 transcript 42 6.50e-02 1.21e-01 0.23000 0.102000 0.207000 2.53e-01 2.04e-02
Pyrimidine salvage 10 6.60e-02 1.22e-01 0.53600 0.397000 0.360000 2.96e-02 4.85e-02
Signaling by GPCR 534 6.64e-02 1.23e-01 0.04530 -0.003380 0.045100 8.94e-01 7.44e-02
TRAF6 mediated NF-kB activation 23 6.80e-02 1.26e-01 0.34700 0.218000 0.270000 6.98e-02 2.49e-02
Biotin transport and metabolism 11 6.81e-02 1.26e-01 0.50000 -0.393000 -0.308000 2.39e-02 7.70e-02
G-protein activation 23 6.81e-02 1.26e-01 0.35200 0.258000 0.239000 3.19e-02 4.71e-02
Josephin domain DUBs 10 6.87e-02 1.27e-01 0.53400 0.369000 0.386000 4.33e-02 3.47e-02
EPH-ephrin mediated repulsion of cells 39 7.00e-02 1.29e-01 0.26900 0.197000 0.184000 3.33e-02 4.73e-02
PKA activation in glucagon signalling 14 7.01e-02 1.29e-01 0.32000 0.055300 0.315000 7.20e-01 4.13e-02
MET activates RAS signaling 10 7.02e-02 1.29e-01 0.52300 0.407000 0.328000 2.57e-02 7.23e-02
Phase II - Conjugation of compounds 66 7.03e-02 1.29e-01 0.20700 0.150000 0.143000 3.52e-02 4.46e-02
Mucopolysaccharidoses 11 7.09e-02 1.30e-01 0.47500 0.256000 0.400000 1.41e-01 2.16e-02
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 79 7.10e-02 1.30e-01 0.13500 0.024700 0.133000 7.04e-01 4.08e-02
Glycogen breakdown (glycogenolysis) 13 7.11e-02 1.30e-01 0.42300 0.208000 0.368000 1.94e-01 2.16e-02
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 7.11e-02 1.30e-01 0.11400 0.020000 -0.113000 7.69e-01 9.84e-02
Diseases of programmed cell death 27 7.13e-02 1.30e-01 0.31900 0.203000 0.246000 6.85e-02 2.70e-02
FRS-mediated FGFR3 signaling 11 7.16e-02 1.30e-01 0.44900 0.398000 0.208000 2.22e-02 2.31e-01
BBSome-mediated cargo-targeting to cilium 22 7.24e-02 1.31e-01 0.18000 0.115000 -0.138000 3.51e-01 2.63e-01
ERKs are inactivated 13 7.24e-02 1.31e-01 0.41500 0.197000 0.366000 2.20e-01 2.23e-02
Negative regulation of FGFR4 signaling 21 7.25e-02 1.31e-01 0.36200 0.238000 0.273000 5.92e-02 3.01e-02
Postmitotic nuclear pore complex (NPC) reformation 27 7.26e-02 1.31e-01 0.24600 -0.067000 -0.237000 5.46e-01 3.30e-02
G alpha (z) signalling events 36 7.26e-02 1.31e-01 0.22400 0.075700 0.211000 4.32e-01 2.82e-02
Apoptosis induced DNA fragmentation 10 7.34e-02 1.32e-01 0.47100 0.221000 0.416000 2.27e-01 2.27e-02
Biosynthesis of specialized proresolving mediators (SPMs) 16 7.39e-02 1.33e-01 0.39700 0.328000 0.225000 2.33e-02 1.20e-01
Activation of GABAB receptors 31 7.43e-02 1.33e-01 0.29500 0.228000 0.187000 2.81e-02 7.14e-02
GABA B receptor activation 31 7.43e-02 1.33e-01 0.29500 0.228000 0.187000 2.81e-02 7.14e-02
mRNA Splicing - Minor Pathway 52 7.44e-02 1.33e-01 0.20900 0.183000 0.103000 2.28e-02 2.01e-01
Transcriptional Regulation by MECP2 47 7.44e-02 1.33e-01 0.14100 -0.023700 0.139000 7.78e-01 9.99e-02
E2F mediated regulation of DNA replication 22 7.51e-02 1.34e-01 0.17800 0.119000 -0.132000 3.34e-01 2.83e-01
Vasopressin regulates renal water homeostasis via Aquaporins 34 7.54e-02 1.35e-01 0.28300 0.189000 0.211000 5.66e-02 3.29e-02
Regulation of MECP2 expression and activity 28 7.55e-02 1.35e-01 0.16100 -0.081900 0.139000 4.53e-01 2.03e-01
Regulated proteolysis of p75NTR 11 7.63e-02 1.36e-01 0.49400 0.317000 0.378000 6.89e-02 2.97e-02
Signaling by FGFR1 38 7.73e-02 1.37e-01 0.25700 0.149000 0.210000 1.13e-01 2.49e-02
Signaling by cytosolic FGFR1 fusion mutants 17 7.77e-02 1.38e-01 0.39900 0.294000 0.270000 3.60e-02 5.37e-02
APC-Cdc20 mediated degradation of Nek2A 26 7.81e-02 1.39e-01 0.21500 0.214000 0.016100 5.85e-02 8.87e-01
Translesion synthesis by REV1 16 7.84e-02 1.39e-01 0.26500 -0.005550 -0.264000 9.69e-01 6.70e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 7.92e-02 1.40e-01 0.23100 0.039600 -0.227000 7.77e-01 1.05e-01
Metabolism of amine-derived hormones 10 7.95e-02 1.40e-01 0.27800 0.102000 -0.258000 5.77e-01 1.57e-01
Aggrephagy 21 8.01e-02 1.41e-01 0.35800 0.258000 0.248000 4.09e-02 4.90e-02
Cyclin A/B1/B2 associated events during G2/M transition 24 8.08e-02 1.43e-01 0.30100 0.264000 0.144000 2.52e-02 2.21e-01
Mitotic Prophase 98 8.23e-02 1.45e-01 0.16500 0.116000 0.118000 4.77e-02 4.39e-02
Polymerase switching on the C-strand of the telomere 26 8.24e-02 1.45e-01 0.24400 -0.064900 -0.235000 5.66e-01 3.81e-02
Peroxisomal lipid metabolism 27 8.24e-02 1.45e-01 0.30600 0.243000 0.186000 2.88e-02 9.39e-02
SUMOylation of immune response proteins 11 8.26e-02 1.45e-01 0.46600 0.260000 0.387000 1.36e-01 2.62e-02
G alpha (12/13) signalling events 68 8.27e-02 1.45e-01 0.12800 0.003830 0.128000 9.56e-01 6.84e-02
Deadenylation of mRNA 22 8.32e-02 1.46e-01 0.34400 0.261000 0.224000 3.38e-02 6.91e-02
Signaling by PDGFRA extracellular domain mutants 12 8.43e-02 1.47e-01 0.45300 0.366000 0.268000 2.83e-02 1.08e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 8.43e-02 1.47e-01 0.45300 0.366000 0.268000 2.83e-02 1.08e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 8.51e-02 1.48e-01 0.17300 0.164000 -0.054900 1.48e-01 6.28e-01
Regulation of signaling by CBL 18 8.53e-02 1.48e-01 0.30100 0.092800 0.286000 4.96e-01 3.57e-02
Constitutive Signaling by EGFRvIII 14 8.58e-02 1.49e-01 0.42500 0.332000 0.265000 3.15e-02 8.63e-02
Signaling by EGFRvIII in Cancer 14 8.58e-02 1.49e-01 0.42500 0.332000 0.265000 3.15e-02 8.63e-02
Negative regulation of the PI3K/AKT network 86 8.59e-02 1.49e-01 0.10200 -0.015100 0.101000 8.09e-01 1.05e-01
HDR through MMEJ (alt-NHEJ) 10 8.62e-02 1.49e-01 0.50000 -0.307000 -0.394000 9.22e-02 3.08e-02
Striated Muscle Contraction 24 8.71e-02 1.51e-01 0.32800 0.244000 0.219000 3.85e-02 6.31e-02
B-WICH complex positively regulates rRNA expression 44 8.75e-02 1.51e-01 0.24300 0.175000 0.169000 4.51e-02 5.23e-02
SHC1 events in ERBB4 signaling 10 8.75e-02 1.51e-01 0.47700 0.403000 0.257000 2.75e-02 1.60e-01
Signalling to RAS 18 8.88e-02 1.53e-01 0.32900 0.296000 0.142000 2.95e-02 2.96e-01
HSF1 activation 26 8.93e-02 1.54e-01 0.19800 0.198000 -0.002720 8.05e-02 9.81e-01
Translesion synthesis by POLI 17 9.03e-02 1.55e-01 0.22700 0.034600 -0.224000 8.05e-01 1.10e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 9.12e-02 1.57e-01 0.35600 0.197000 0.297000 1.48e-01 2.92e-02
mRNA Capping 29 9.17e-02 1.57e-01 0.29400 0.193000 0.222000 7.28e-02 3.81e-02
SIRT1 negatively regulates rRNA expression 24 9.33e-02 1.60e-01 0.31200 0.180000 0.254000 1.26e-01 3.10e-02
FRS-mediated FGFR4 signaling 12 9.35e-02 1.60e-01 0.38900 0.356000 0.156000 3.27e-02 3.49e-01
Gap junction trafficking and regulation 15 9.39e-02 1.60e-01 0.37600 0.190000 0.324000 2.03e-01 2.96e-02
Surfactant metabolism 22 9.40e-02 1.60e-01 0.33700 0.250000 0.227000 4.24e-02 6.58e-02
Translesion Synthesis by POLH 18 9.42e-02 1.60e-01 0.18800 0.122000 -0.143000 3.69e-01 2.94e-01
Phosphorylation of the APC/C 20 9.46e-02 1.61e-01 0.28800 0.270000 0.101000 3.65e-02 4.36e-01
Nuclear Pore Complex (NPC) Disassembly 36 9.50e-02 1.61e-01 0.17500 -0.012400 -0.175000 8.97e-01 6.97e-02
Processive synthesis on the C-strand of the telomere 19 9.57e-02 1.63e-01 0.21800 0.021100 -0.217000 8.73e-01 1.02e-01
Stimuli-sensing channels 72 9.65e-02 1.64e-01 0.18600 0.126000 0.137000 6.48e-02 4.48e-02
FGFR2 alternative splicing 25 9.80e-02 1.66e-01 0.28300 0.249000 0.136000 3.15e-02 2.39e-01
PRC2 methylates histones and DNA 29 9.82e-02 1.66e-01 0.21400 0.045400 0.209000 6.72e-01 5.16e-02
Glyoxylate metabolism and glycine degradation 24 9.84e-02 1.66e-01 0.23000 0.226000 0.042100 5.54e-02 7.21e-01
SHC1 events in ERBB2 signaling 17 9.93e-02 1.67e-01 0.38000 0.275000 0.262000 4.95e-02 6.10e-02
mRNA decay by 3’ to 5’ exoribonuclease 16 9.95e-02 1.68e-01 0.22800 0.035900 -0.226000 8.04e-01 1.18e-01
Frs2-mediated activation 11 9.96e-02 1.68e-01 0.40600 0.171000 0.369000 3.27e-01 3.42e-02
Metabolism of steroid hormones 19 1.01e-01 1.69e-01 0.32800 0.284000 0.163000 3.21e-02 2.18e-01
Sema4D induced cell migration and growth-cone collapse 19 1.01e-01 1.69e-01 0.29100 0.101000 0.273000 4.47e-01 3.93e-02
Glycolysis 66 1.02e-01 1.71e-01 0.18300 0.151000 0.104000 3.36e-02 1.45e-01
Synthesis, secretion, and deacylation of Ghrelin 11 1.05e-01 1.75e-01 0.24100 0.211000 -0.118000 2.26e-01 4.99e-01
NOTCH3 Intracellular Domain Regulates Transcription 20 1.06e-01 1.77e-01 0.19800 -0.039500 0.194000 7.60e-01 1.34e-01
PKA activation 15 1.06e-01 1.77e-01 0.23800 -0.025900 0.237000 8.62e-01 1.12e-01
TGF-beta receptor signaling activates SMADs 32 1.06e-01 1.77e-01 0.24000 0.107000 0.215000 2.95e-01 3.55e-02
Translesion synthesis by POLK 17 1.07e-01 1.78e-01 0.21200 0.045700 -0.207000 7.44e-01 1.39e-01
Signaling by NOTCH3 42 1.07e-01 1.78e-01 0.20000 0.077200 0.184000 3.87e-01 3.91e-02
HIV elongation arrest and recovery 32 1.08e-01 1.80e-01 0.21200 0.063100 0.203000 5.37e-01 4.71e-02
Pausing and recovery of HIV elongation 32 1.08e-01 1.80e-01 0.21200 0.063100 0.203000 5.37e-01 4.71e-02
ISG15 antiviral mechanism 72 1.09e-01 1.81e-01 0.13800 -0.036400 -0.133000 5.93e-01 5.10e-02
Signaling by FGFR2 in disease 32 1.11e-01 1.84e-01 0.20700 0.199000 0.055700 5.12e-02 5.85e-01
GPCR downstream signalling 489 1.11e-01 1.84e-01 0.04360 -0.001320 0.043600 9.60e-01 9.88e-02
Olfactory Signaling Pathway 55 1.12e-01 1.85e-01 0.17100 0.159000 0.063700 4.20e-02 4.14e-01
Arachidonic acid metabolism 42 1.12e-01 1.85e-01 0.23400 0.178000 0.152000 4.62e-02 8.85e-02
Formation of the cornified envelope 21 1.13e-01 1.86e-01 0.31900 0.261000 0.183000 3.82e-02 1.47e-01
SLBP independent Processing of Histone Pre-mRNAs 10 1.13e-01 1.86e-01 0.26600 0.256000 -0.073300 1.61e-01 6.88e-01
Nuclear signaling by ERBB4 24 1.15e-01 1.89e-01 0.28200 0.140000 0.245000 2.36e-01 3.75e-02
NGF-stimulated transcription 31 1.15e-01 1.89e-01 0.26600 0.162000 0.211000 1.19e-01 4.18e-02
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.15e-01 1.89e-01 0.36200 0.113000 0.343000 5.16e-01 4.86e-02
Glutamate Neurotransmitter Release Cycle 20 1.16e-01 1.89e-01 0.17300 0.092500 -0.147000 4.74e-01 2.56e-01
NCAM1 interactions 23 1.16e-01 1.90e-01 0.25400 -0.085900 -0.240000 4.76e-01 4.67e-02
SHC-mediated cascade:FGFR4 10 1.17e-01 1.91e-01 0.33600 0.332000 0.052700 6.93e-02 7.73e-01
Receptor Mediated Mitophagy 11 1.17e-01 1.91e-01 0.45100 0.293000 0.344000 9.29e-02 4.83e-02
GABA synthesis, release, reuptake and degradation 13 1.17e-01 1.91e-01 0.21500 0.182000 -0.113000 2.55e-01 4.81e-01
Deadenylation-dependent mRNA decay 53 1.17e-01 1.91e-01 0.15300 0.150000 0.034600 5.97e-02 6.63e-01
Mitotic Telophase/Cytokinesis 13 1.17e-01 1.91e-01 0.38300 0.191000 0.331000 2.33e-01 3.85e-02
Tryptophan catabolism 12 1.18e-01 1.92e-01 0.42900 0.334000 0.269000 4.54e-02 1.06e-01
SLC-mediated transmembrane transport 178 1.18e-01 1.92e-01 0.10200 0.048100 0.089600 2.68e-01 3.93e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 1.18e-01 1.92e-01 0.23200 0.086800 0.215000 4.19e-01 4.46e-02
Glycogen storage diseases 13 1.21e-01 1.95e-01 0.41500 0.307000 0.279000 5.50e-02 8.18e-02
Interleukin-15 signaling 14 1.22e-01 1.97e-01 0.37100 0.317000 0.193000 4.01e-02 2.12e-01
Tight junction interactions 18 1.22e-01 1.97e-01 0.17800 0.107000 -0.143000 4.31e-01 2.94e-01
Endogenous sterols 16 1.22e-01 1.97e-01 0.37400 0.269000 0.260000 6.25e-02 7.18e-02
Collagen chain trimerization 27 1.23e-01 1.98e-01 0.16000 -0.155000 0.041000 1.63e-01 7.13e-01
Synthesis of PIPs at the late endosome membrane 11 1.25e-01 2.00e-01 0.36500 0.127000 0.342000 4.65e-01 4.95e-02
Misspliced GSK3beta mutants stabilize beta-catenin 15 1.25e-01 2.00e-01 0.27200 0.045400 0.268000 7.61e-01 7.23e-02
S33 mutants of beta-catenin aren’t phosphorylated 15 1.25e-01 2.00e-01 0.27200 0.045400 0.268000 7.61e-01 7.23e-02
S37 mutants of beta-catenin aren’t phosphorylated 15 1.25e-01 2.00e-01 0.27200 0.045400 0.268000 7.61e-01 7.23e-02
S45 mutants of beta-catenin aren’t phosphorylated 15 1.25e-01 2.00e-01 0.27200 0.045400 0.268000 7.61e-01 7.23e-02
T41 mutants of beta-catenin aren’t phosphorylated 15 1.25e-01 2.00e-01 0.27200 0.045400 0.268000 7.61e-01 7.23e-02
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 1.25e-01 2.00e-01 0.27200 0.045400 0.268000 7.61e-01 7.23e-02
Pausing and recovery of Tat-mediated HIV elongation 30 1.26e-01 2.00e-01 0.21900 0.074400 0.206000 4.81e-01 5.08e-02
Tat-mediated HIV elongation arrest and recovery 30 1.26e-01 2.00e-01 0.21900 0.074400 0.206000 4.81e-01 5.08e-02
TICAM1, RIP1-mediated IKK complex recruitment 19 1.27e-01 2.01e-01 0.33400 0.261000 0.209000 4.86e-02 1.15e-01
Cellular response to heat stress 93 1.27e-01 2.02e-01 0.08320 0.027900 -0.078500 6.43e-01 1.91e-01
Interleukin-37 signaling 19 1.30e-01 2.07e-01 0.17100 -0.105000 0.135000 4.29e-01 3.09e-01
Metalloprotease DUBs 21 1.32e-01 2.09e-01 0.31200 0.187000 0.249000 1.37e-01 4.79e-02
Signaling by FGFR2 IIIa TM 18 1.34e-01 2.12e-01 0.33200 0.270000 0.193000 4.71e-02 1.57e-01
Regulation of HSF1-mediated heat shock response 79 1.34e-01 2.13e-01 0.08770 0.033400 -0.081100 6.08e-01 2.13e-01
Cholesterol biosynthesis 24 1.35e-01 2.14e-01 0.29800 0.211000 0.210000 7.30e-02 7.48e-02
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 1.36e-01 2.16e-01 0.24200 0.240000 0.029200 8.62e-02 8.35e-01
Nuclear Receptor transcription pathway 37 1.39e-01 2.20e-01 0.17200 -0.169000 -0.033900 7.53e-02 7.21e-01
Potassium Channels 63 1.40e-01 2.20e-01 0.18100 0.137000 0.118000 5.91e-02 1.06e-01
Keratan sulfate/keratin metabolism 25 1.41e-01 2.22e-01 0.19300 0.015900 0.192000 8.91e-01 9.60e-02
Regulation of RUNX1 Expression and Activity 18 1.42e-01 2.24e-01 0.23000 -0.229000 -0.023600 9.28e-02 8.62e-01
RNA Polymerase II Transcription Termination 65 1.43e-01 2.25e-01 0.14200 0.134000 0.045400 6.08e-02 5.27e-01
Metabolism of fat-soluble vitamins 28 1.44e-01 2.26e-01 0.19900 0.042000 0.194000 7.01e-01 7.55e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 1.45e-01 2.27e-01 0.19300 -0.018400 0.192000 8.86e-01 1.37e-01
Trafficking of AMPA receptors 20 1.45e-01 2.27e-01 0.19300 -0.018400 0.192000 8.86e-01 1.37e-01
Cell-extracellular matrix interactions 14 1.45e-01 2.27e-01 0.36300 0.200000 0.302000 1.94e-01 5.04e-02
Phase I - Functionalization of compounds 61 1.46e-01 2.28e-01 0.16800 0.145000 0.083900 4.99e-02 2.57e-01
RMTs methylate histone arginines 37 1.47e-01 2.28e-01 0.11900 -0.097700 0.068600 3.04e-01 4.70e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 1.47e-01 2.28e-01 0.21300 0.211000 0.023900 9.35e-02 8.50e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 1.47e-01 2.28e-01 0.21300 0.211000 0.023900 9.35e-02 8.50e-01
Activated NOTCH1 Transmits Signal to the Nucleus 27 1.47e-01 2.29e-01 0.23900 0.104000 0.215000 3.49e-01 5.26e-02
Intrinsic Pathway of Fibrin Clot Formation 16 1.49e-01 2.31e-01 0.35600 0.260000 0.243000 7.22e-02 9.19e-02
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.49e-01 2.31e-01 0.16300 -0.038100 -0.159000 6.69e-01 7.48e-02
Signaling by FGFR 69 1.50e-01 2.33e-01 0.17100 0.126000 0.116000 7.13e-02 9.57e-02
Regulation of TP53 Activity 152 1.51e-01 2.33e-01 0.11300 -0.089600 -0.068100 5.67e-02 1.47e-01
Activation of BAD and translocation to mitochondria 15 1.51e-01 2.33e-01 0.36200 0.278000 0.232000 6.23e-02 1.20e-01
CASP8 activity is inhibited 11 1.51e-01 2.33e-01 0.22400 0.098500 -0.201000 5.72e-01 2.49e-01
Dimerization of procaspase-8 11 1.51e-01 2.33e-01 0.22400 0.098500 -0.201000 5.72e-01 2.49e-01
Regulation by c-FLIP 11 1.51e-01 2.33e-01 0.22400 0.098500 -0.201000 5.72e-01 2.49e-01
Acyl chain remodelling of PC 19 1.52e-01 2.33e-01 0.32100 0.204000 0.248000 1.24e-01 6.15e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.53e-01 2.35e-01 0.14700 -0.016700 -0.146000 8.50e-01 9.69e-02
G beta:gamma signalling through PLC beta 17 1.53e-01 2.35e-01 0.34300 0.248000 0.237000 7.72e-02 9.07e-02
Presynaptic function of Kainate receptors 17 1.53e-01 2.35e-01 0.34300 0.248000 0.237000 7.72e-02 9.07e-02
Trafficking and processing of endosomal TLR 13 1.53e-01 2.35e-01 0.37600 0.307000 0.217000 5.49e-02 1.76e-01
G beta:gamma signalling through BTK 15 1.56e-01 2.38e-01 0.36000 0.274000 0.234000 6.63e-02 1.17e-01
Acyl chain remodelling of PI 10 1.56e-01 2.39e-01 0.38400 0.164000 0.348000 3.70e-01 5.69e-02
Elastic fibre formation 31 1.58e-01 2.41e-01 0.22500 0.106000 0.199000 3.06e-01 5.56e-02
Downstream signaling of activated FGFR3 16 1.59e-01 2.43e-01 0.31400 0.276000 0.150000 5.58e-02 2.98e-01
p75NTR signals via NF-kB 15 1.61e-01 2.45e-01 0.33700 0.285000 0.180000 5.62e-02 2.27e-01
Sialic acid metabolism 28 1.63e-01 2.48e-01 0.25400 0.149000 0.205000 1.73e-01 5.99e-02
Signaling by NTRK2 (TRKB) 20 1.63e-01 2.48e-01 0.29200 0.245000 0.158000 5.74e-02 2.21e-01
Signaling by ERBB2 in Cancer 21 1.63e-01 2.48e-01 0.29800 0.233000 0.186000 6.47e-02 1.41e-01
Early Phase of HIV Life Cycle 14 1.65e-01 2.51e-01 0.18700 0.147000 -0.116000 3.42e-01 4.54e-01
SUMOylation of transcription factors 16 1.66e-01 2.52e-01 0.28500 0.104000 0.265000 4.72e-01 6.65e-02
Assembly of collagen fibrils and other multimeric structures 42 1.68e-01 2.54e-01 0.12700 -0.014800 0.126000 8.69e-01 1.59e-01
Ca-dependent events 29 1.69e-01 2.55e-01 0.22700 0.105000 0.201000 3.29e-01 6.04e-02
Negative regulators of DDX58/IFIH1 signaling 34 1.70e-01 2.56e-01 0.13400 0.131000 -0.028200 1.86e-01 7.76e-01
Assembly and cell surface presentation of NMDA receptors 18 1.71e-01 2.57e-01 0.17700 0.054400 -0.168000 6.90e-01 2.17e-01
Chromosome Maintenance 105 1.72e-01 2.59e-01 0.07040 0.029800 -0.063700 5.98e-01 2.59e-01
Constitutive Signaling by Overexpressed ERBB2 11 1.74e-01 2.61e-01 0.40300 0.318000 0.248000 6.82e-02 1.54e-01
Cytosolic iron-sulfur cluster assembly 13 1.75e-01 2.62e-01 0.26300 -0.260000 -0.036900 1.04e-01 8.18e-01
The role of Nef in HIV-1 replication and disease pathogenesis 28 1.75e-01 2.62e-01 0.25500 0.163000 0.196000 1.36e-01 7.30e-02
Transport of vitamins, nucleosides, and related molecules 32 1.76e-01 2.65e-01 0.17600 0.038200 0.172000 7.09e-01 9.17e-02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.77e-01 2.65e-01 0.21400 0.029300 -0.212000 8.49e-01 1.70e-01
Retinoid metabolism and transport 24 1.79e-01 2.67e-01 0.19100 0.024800 0.189000 8.33e-01 1.09e-01
Signaling by ERBB2 44 1.80e-01 2.68e-01 0.19000 0.099800 0.161000 2.52e-01 6.40e-02
Regulation of TNFR1 signaling 34 1.80e-01 2.68e-01 0.14600 0.002050 -0.146000 9.83e-01 1.41e-01
Initiation of Nuclear Envelope (NE) Reformation 19 1.80e-01 2.69e-01 0.30100 0.180000 0.241000 1.75e-01 6.88e-02
Regulation of PTEN mRNA translation 13 1.81e-01 2.69e-01 0.23400 -0.233000 0.006950 1.45e-01 9.65e-01
SUMOylation of RNA binding proteins 47 1.81e-01 2.69e-01 0.13900 -0.022500 -0.137000 7.90e-01 1.04e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 1.82e-01 2.70e-01 0.27500 -0.274000 -0.028400 1.16e-01 8.70e-01
Transport of Mature Transcript to Cytoplasm 81 1.82e-01 2.70e-01 0.08060 0.028200 -0.075600 6.61e-01 2.40e-01
Removal of the Flap Intermediate from the C-strand 17 1.83e-01 2.71e-01 0.18500 0.039400 -0.181000 7.79e-01 1.96e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 1.84e-01 2.72e-01 0.31700 -0.094700 -0.302000 5.86e-01 8.27e-02
ECM proteoglycans 34 1.84e-01 2.73e-01 0.14300 -0.004800 0.143000 9.61e-01 1.48e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 1.85e-01 2.73e-01 0.32200 -0.207000 -0.247000 1.40e-01 7.85e-02
Downstream signaling of activated FGFR4 17 1.85e-01 2.73e-01 0.27900 0.254000 0.117000 7.02e-02 4.05e-01
Formation of Incision Complex in GG-NER 43 1.85e-01 2.73e-01 0.20500 0.147000 0.142000 9.56e-02 1.06e-01
RA biosynthesis pathway 13 1.86e-01 2.73e-01 0.33000 -0.152000 -0.293000 3.41e-01 6.77e-02
Insulin receptor signalling cascade 39 1.86e-01 2.73e-01 0.20600 0.120000 0.168000 1.96e-01 6.92e-02
GRB2 events in ERBB2 signaling 11 1.87e-01 2.75e-01 0.36200 0.318000 0.173000 6.77e-02 3.19e-01
SUMOylation of SUMOylation proteins 35 1.88e-01 2.75e-01 0.17000 -0.043300 -0.165000 6.58e-01 9.14e-02
Cardiac conduction 86 1.88e-01 2.75e-01 0.08970 -0.089600 0.003050 1.51e-01 9.61e-01
PI3K/AKT Signaling in Cancer 80 1.90e-01 2.79e-01 0.07840 -0.032500 0.071400 6.15e-01 2.70e-01
SHC-mediated cascade:FGFR2 12 1.96e-01 2.88e-01 0.19500 0.165000 -0.103000 3.22e-01 5.38e-01
RNA Polymerase I Promoter Clearance 63 1.99e-01 2.91e-01 0.14600 0.065800 0.130000 3.66e-01 7.43e-02
RNA Polymerase I Transcription 63 1.99e-01 2.91e-01 0.14600 0.065800 0.130000 3.66e-01 7.43e-02
Synthesis of very long-chain fatty acyl-CoAs 21 2.00e-01 2.92e-01 0.28400 0.213000 0.188000 9.08e-02 1.36e-01
Aflatoxin activation and detoxification 14 2.01e-01 2.93e-01 0.25300 0.248000 0.050500 1.08e-01 7.44e-01
Signaling by Hippo 18 2.02e-01 2.94e-01 0.26500 0.112000 0.240000 4.11e-01 7.75e-02
Assembly of active LPL and LIPC lipase complexes 10 2.02e-01 2.94e-01 0.25900 -0.004810 0.259000 9.79e-01 1.56e-01
Metabolism of cofactors 19 2.03e-01 2.95e-01 0.28700 0.235000 0.165000 7.66e-02 2.13e-01
Cargo trafficking to the periciliary membrane 47 2.04e-01 2.96e-01 0.17600 0.150000 0.092400 7.47e-02 2.73e-01
Ion homeostasis 41 2.06e-01 2.99e-01 0.11000 -0.104000 0.035300 2.48e-01 6.95e-01
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.07e-01 3.00e-01 0.26500 0.164000 0.208000 1.75e-01 8.39e-02
AMER1 mutants destabilize the destruction complex 14 2.09e-01 3.00e-01 0.24200 0.036700 0.239000 8.12e-01 1.21e-01
APC truncation mutants have impaired AXIN binding 14 2.09e-01 3.00e-01 0.24200 0.036700 0.239000 8.12e-01 1.21e-01
AXIN missense mutants destabilize the destruction complex 14 2.09e-01 3.00e-01 0.24200 0.036700 0.239000 8.12e-01 1.21e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 2.09e-01 3.00e-01 0.24200 0.036700 0.239000 8.12e-01 1.21e-01
Truncations of AMER1 destabilize the destruction complex 14 2.09e-01 3.00e-01 0.24200 0.036700 0.239000 8.12e-01 1.21e-01
truncated APC mutants destabilize the destruction complex 14 2.09e-01 3.00e-01 0.24200 0.036700 0.239000 8.12e-01 1.21e-01
Post-chaperonin tubulin folding pathway 19 2.10e-01 3.02e-01 0.25900 0.114000 0.232000 3.89e-01 7.99e-02
Metabolism of folate and pterines 16 2.11e-01 3.03e-01 0.29400 0.255000 0.148000 7.79e-02 3.07e-01
Nuclear Envelope (NE) Reassembly 69 2.12e-01 3.04e-01 0.15400 0.117000 0.099200 9.24e-02 1.54e-01
Inositol phosphate metabolism 42 2.13e-01 3.05e-01 0.11900 -0.011100 0.119000 9.01e-01 1.83e-01
Interleukin-6 family signaling 18 2.13e-01 3.05e-01 0.27100 0.239000 0.128000 7.97e-02 3.47e-01
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 2.14e-01 3.06e-01 0.23400 -0.124000 -0.199000 2.73e-01 7.93e-02
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 2.14e-01 3.06e-01 0.10300 -0.041300 0.094900 6.39e-01 2.82e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 2.16e-01 3.08e-01 0.25500 0.146000 0.209000 2.25e-01 8.22e-02
DAP12 interactions 39 2.16e-01 3.08e-01 0.20500 0.141000 0.149000 1.29e-01 1.08e-01
Long-term potentiation 14 2.17e-01 3.09e-01 0.21400 0.004190 -0.214000 9.78e-01 1.66e-01
Cytosolic sulfonation of small molecules 18 2.21e-01 3.14e-01 0.20700 0.028500 0.205000 8.34e-01 1.31e-01
Nonhomologous End-Joining (NHEJ) 42 2.22e-01 3.15e-01 0.15100 0.042500 0.145000 6.33e-01 1.05e-01
Transcriptional activation of mitochondrial biogenesis 51 2.22e-01 3.16e-01 0.15700 0.072000 0.140000 3.74e-01 8.46e-02
Regulation of FOXO transcriptional activity by acetylation 10 2.23e-01 3.16e-01 0.20400 -0.170000 0.113000 3.53e-01 5.37e-01
G beta:gamma signalling through PI3Kgamma 22 2.23e-01 3.16e-01 0.21300 0.066100 0.202000 5.91e-01 1.01e-01
Signaling by PDGF 44 2.25e-01 3.18e-01 0.16500 0.071100 0.149000 4.14e-01 8.75e-02
FRS-mediated FGFR1 signaling 14 2.25e-01 3.18e-01 0.32000 0.266000 0.178000 8.54e-02 2.48e-01
Negative regulation of MAPK pathway 42 2.25e-01 3.18e-01 0.18600 0.105000 0.153000 2.40e-01 8.59e-02
Telomere C-strand synthesis initiation 13 2.25e-01 3.18e-01 0.29900 -0.124000 -0.272000 4.39e-01 8.92e-02
Purine salvage 12 2.29e-01 3.22e-01 0.31900 0.285000 0.145000 8.77e-02 3.85e-01
Heme degradation 10 2.29e-01 3.22e-01 0.38000 0.218000 0.311000 2.33e-01 8.85e-02
TICAM1-dependent activation of IRF3/IRF7 12 2.29e-01 3.22e-01 0.22300 0.222000 -0.011500 1.82e-01 9.45e-01
Synthesis of IP3 and IP4 in the cytosol 22 2.31e-01 3.24e-01 0.13700 -0.068900 0.119000 5.76e-01 3.35e-01
Prolactin receptor signaling 11 2.31e-01 3.24e-01 0.25100 0.250000 0.019700 1.51e-01 9.10e-01
Cell death signalling via NRAGE, NRIF and NADE 69 2.32e-01 3.25e-01 0.11400 0.029900 0.110000 6.68e-01 1.13e-01
Chondroitin sulfate biosynthesis 12 2.33e-01 3.26e-01 0.32700 0.161000 0.284000 3.35e-01 8.80e-02
Transcriptional regulation of pluripotent stem cells 20 2.33e-01 3.26e-01 0.14300 -0.075300 0.121000 5.60e-01 3.48e-01
p38MAPK events 13 2.35e-01 3.29e-01 0.33500 0.268000 0.201000 9.47e-02 2.10e-01
Transcriptional Regulation by E2F6 34 2.37e-01 3.31e-01 0.16800 -0.052700 -0.160000 5.95e-01 1.07e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 2.37e-01 3.31e-01 0.37100 0.244000 0.279000 1.61e-01 1.09e-01
Signaling by ERBB2 TMD/JMD mutants 17 2.39e-01 3.33e-01 0.27600 0.237000 0.142000 9.06e-02 3.12e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 2.39e-01 3.33e-01 0.13400 -0.109000 0.077500 3.77e-01 5.29e-01
NRAGE signals death through JNK 52 2.40e-01 3.33e-01 0.08610 -0.066000 0.055300 4.10e-01 4.90e-01
Signaling by FGFR3 in disease 13 2.40e-01 3.33e-01 0.22000 0.220000 0.005200 1.70e-01 9.74e-01
Signaling by FGFR3 point mutants in cancer 13 2.40e-01 3.33e-01 0.22000 0.220000 0.005200 1.70e-01 9.74e-01
STING mediated induction of host immune responses 15 2.40e-01 3.33e-01 0.23200 0.227000 0.047500 1.29e-01 7.50e-01
Post-translational modification: synthesis of GPI-anchored proteins 56 2.41e-01 3.34e-01 0.13900 0.128000 0.054800 9.86e-02 4.78e-01
CD28 dependent Vav1 pathway 12 2.41e-01 3.34e-01 0.30400 0.277000 0.126000 9.69e-02 4.51e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 2.45e-01 3.38e-01 0.29500 0.173000 0.239000 2.32e-01 9.73e-02
NOTCH4 Intracellular Domain Regulates Transcription 17 2.45e-01 3.39e-01 0.16900 -0.165000 0.035700 2.40e-01 7.99e-01
Triglyceride metabolism 25 2.46e-01 3.39e-01 0.24100 0.151000 0.187000 1.91e-01 1.05e-01
Regulation of TP53 Activity through Association with Co-factors 12 2.47e-01 3.40e-01 0.34600 -0.270000 -0.217000 1.05e-01 1.93e-01
Listeria monocytogenes entry into host cells 17 2.47e-01 3.40e-01 0.29600 0.201000 0.217000 1.51e-01 1.22e-01
Rap1 signalling 13 2.49e-01 3.42e-01 0.30700 0.152000 0.267000 3.42e-01 9.55e-02
Processing and activation of SUMO 10 2.50e-01 3.44e-01 0.37700 0.295000 0.234000 1.06e-01 2.00e-01
Signaling by ERBB2 KD Mutants 20 2.51e-01 3.45e-01 0.26000 0.213000 0.148000 9.89e-02 2.50e-01
Metal ion SLC transporters 21 2.53e-01 3.47e-01 0.26000 0.201000 0.165000 1.10e-01 1.90e-01
FRS-mediated FGFR2 signaling 14 2.54e-01 3.47e-01 0.21000 0.210000 0.008100 1.74e-01 9.58e-01
VEGFR2 mediated cell proliferation 18 2.60e-01 3.56e-01 0.21500 0.057000 0.207000 6.75e-01 1.28e-01
Adenylate cyclase inhibitory pathway 11 2.61e-01 3.57e-01 0.22200 -0.011300 0.222000 9.48e-01 2.03e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 2.62e-01 3.58e-01 0.14000 0.116000 -0.077800 3.82e-01 5.57e-01
Keratinization 33 2.63e-01 3.59e-01 0.16600 0.157000 0.054600 1.19e-01 5.87e-01
Organelle biogenesis and maintenance 268 2.66e-01 3.62e-01 0.07210 0.055600 0.045800 1.17e-01 1.97e-01
MECP2 regulates neuronal receptors and channels 13 2.67e-01 3.64e-01 0.17300 -0.073900 0.156000 6.45e-01 3.30e-01
Purine catabolism 16 2.68e-01 3.64e-01 0.24500 0.228000 0.091600 1.15e-01 5.26e-01
TNFR1-induced NFkappaB signaling pathway 25 2.71e-01 3.68e-01 0.12000 0.070200 -0.096800 5.43e-01 4.02e-01
Plasma lipoprotein remodeling 18 2.71e-01 3.68e-01 0.22100 0.070800 0.209000 6.03e-01 1.24e-01
Miscellaneous transport and binding events 20 2.71e-01 3.68e-01 0.20400 0.058400 0.195000 6.51e-01 1.30e-01
FOXO-mediated transcription of cell cycle genes 15 2.73e-01 3.70e-01 0.24000 -0.228000 -0.074700 1.27e-01 6.16e-01
Biosynthesis of DHA-derived SPMs 14 2.74e-01 3.71e-01 0.28400 0.248000 0.138000 1.08e-01 3.72e-01
Apoptotic cleavage of cellular proteins 34 2.76e-01 3.74e-01 0.17600 0.078700 0.158000 4.27e-01 1.11e-01
Eicosanoid ligand-binding receptors 13 2.77e-01 3.74e-01 0.19900 0.011200 -0.199000 9.44e-01 2.14e-01
Pexophagy 11 2.81e-01 3.79e-01 0.34800 0.227000 0.264000 1.92e-01 1.30e-01
Endosomal/Vacuolar pathway 12 2.82e-01 3.80e-01 0.33000 -0.208000 -0.256000 2.12e-01 1.24e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 2.82e-01 3.80e-01 0.12300 -0.072100 0.099200 5.50e-01 4.10e-01
Cohesin Loading onto Chromatin 10 2.85e-01 3.84e-01 0.27400 0.066500 0.265000 7.16e-01 1.46e-01
Keratan sulfate biosynthesis 20 2.86e-01 3.84e-01 0.13300 -0.116000 0.065600 3.69e-01 6.12e-01
NRIF signals cell death from the nucleus 15 2.86e-01 3.84e-01 0.26600 0.235000 0.124000 1.15e-01 4.07e-01
Epigenetic regulation of gene expression 100 2.87e-01 3.85e-01 0.07800 0.007610 0.077600 8.95e-01 1.80e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 2.87e-01 3.85e-01 0.23100 0.204000 0.110000 1.15e-01 3.96e-01
Mismatch Repair 15 2.89e-01 3.86e-01 0.15900 0.057700 -0.148000 6.99e-01 3.20e-01
FGFR2 mutant receptor activation 22 2.89e-01 3.87e-01 0.17700 0.174000 0.034500 1.59e-01 7.79e-01
Nephrin family interactions 18 2.90e-01 3.88e-01 0.21300 -0.203000 -0.066200 1.36e-01 6.27e-01
Zinc transporters 14 2.92e-01 3.89e-01 0.28900 0.242000 0.159000 1.18e-01 3.03e-01
Insulin processing 20 2.93e-01 3.90e-01 0.25500 0.190000 0.169000 1.41e-01 1.90e-01
Neurotransmitter release cycle 38 2.93e-01 3.90e-01 0.10300 0.099700 -0.026900 2.88e-01 7.74e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 2.95e-01 3.92e-01 0.16500 0.111000 -0.122000 5.04e-01 4.64e-01
PKA-mediated phosphorylation of CREB 17 2.96e-01 3.93e-01 0.16100 -0.025200 0.159000 8.57e-01 2.56e-01
Synthesis of PE 12 2.96e-01 3.93e-01 0.23700 -0.045600 -0.232000 7.85e-01 1.63e-01
TP53 Regulates Transcription of Death Receptors and Ligands 12 2.96e-01 3.93e-01 0.17800 0.168000 -0.058100 3.12e-01 7.28e-01
Acetylcholine Neurotransmitter Release Cycle 11 2.97e-01 3.94e-01 0.25500 -0.059800 -0.248000 7.31e-01 1.55e-01
SUMOylation of DNA replication proteins 46 2.97e-01 3.94e-01 0.10900 -0.003620 -0.109000 9.66e-01 2.03e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 2.98e-01 3.94e-01 0.18900 0.184000 0.045100 1.54e-01 7.27e-01
Signaling by PDGFR in disease 19 3.01e-01 3.97e-01 0.25300 0.152000 0.202000 2.50e-01 1.28e-01
Negative regulation of FGFR2 signaling 23 3.02e-01 3.98e-01 0.23500 0.159000 0.173000 1.87e-01 1.51e-01
CD209 (DC-SIGN) signaling 20 3.03e-01 3.99e-01 0.23700 0.199000 0.129000 1.23e-01 3.18e-01
SUMOylation of chromatin organization proteins 57 3.06e-01 4.03e-01 0.11200 -0.027700 -0.108000 7.18e-01 1.57e-01
Ca2+ pathway 57 3.10e-01 4.08e-01 0.12900 0.056900 0.116000 4.57e-01 1.29e-01
Positive epigenetic regulation of rRNA expression 59 3.10e-01 4.08e-01 0.13600 0.072200 0.115000 3.37e-01 1.26e-01
Downstream signal transduction 27 3.10e-01 4.08e-01 0.18400 0.076300 0.167000 4.92e-01 1.32e-01
RET signaling 32 3.16e-01 4.14e-01 0.18500 0.101000 0.155000 3.23e-01 1.30e-01
Regulation of IFNA signaling 12 3.17e-01 4.15e-01 0.26900 0.106000 0.247000 5.25e-01 1.38e-01
Disorders of Developmental Biology 12 3.18e-01 4.15e-01 0.20400 0.002910 0.204000 9.86e-01 2.21e-01
Disorders of Nervous System Development 12 3.18e-01 4.15e-01 0.20400 0.002910 0.204000 9.86e-01 2.21e-01
Loss of function of MECP2 in Rett syndrome 12 3.18e-01 4.15e-01 0.20400 0.002910 0.204000 9.86e-01 2.21e-01
Pervasive developmental disorders 12 3.18e-01 4.15e-01 0.20400 0.002910 0.204000 9.86e-01 2.21e-01
Fatty acyl-CoA biosynthesis 33 3.18e-01 4.15e-01 0.19000 0.121000 0.146000 2.28e-01 1.46e-01
Signaling by ERBB2 ECD mutants 15 3.19e-01 4.15e-01 0.26800 0.225000 0.146000 1.31e-01 3.28e-01
cGMP effects 12 3.19e-01 4.15e-01 0.22600 0.038000 0.223000 8.20e-01 1.82e-01
Prostacyclin signalling through prostacyclin receptor 16 3.19e-01 4.15e-01 0.26400 0.217000 0.152000 1.34e-01 2.94e-01
EPHA-mediated growth cone collapse 13 3.20e-01 4.16e-01 0.27700 0.136000 0.242000 3.96e-01 1.31e-01
Protein methylation 15 3.20e-01 4.16e-01 0.28400 0.205000 0.197000 1.69e-01 1.87e-01
Acyl chain remodelling of PG 11 3.21e-01 4.16e-01 0.32300 0.194000 0.258000 2.66e-01 1.39e-01
Glutamate and glutamine metabolism 12 3.21e-01 4.16e-01 0.16100 0.129000 -0.095400 4.37e-01 5.67e-01
Heme biosynthesis 14 3.23e-01 4.18e-01 0.27500 0.147000 0.232000 3.40e-01 1.33e-01
Beta-oxidation of very long chain fatty acids 10 3.23e-01 4.18e-01 0.33100 0.187000 0.273000 3.05e-01 1.35e-01
TP53 Regulates Transcription of DNA Repair Genes 61 3.24e-01 4.18e-01 0.07090 -0.055500 0.044100 4.54e-01 5.51e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 3.26e-01 4.21e-01 0.18200 0.182000 -0.016800 2.57e-01 9.17e-01
CLEC7A (Dectin-1) induces NFAT activation 11 3.26e-01 4.21e-01 0.17500 -0.162000 0.067100 3.53e-01 7.00e-01
Tie2 Signaling 16 3.33e-01 4.29e-01 0.26300 0.157000 0.211000 2.77e-01 1.45e-01
ERBB2 Regulates Cell Motility 10 3.33e-01 4.29e-01 0.32100 0.173000 0.271000 3.44e-01 1.39e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 3.34e-01 4.30e-01 0.16600 0.030400 -0.163000 8.44e-01 2.90e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 3.35e-01 4.30e-01 0.15000 0.133000 -0.069200 3.88e-01 6.54e-01
Resolution of D-Loop Structures 33 3.38e-01 4.34e-01 0.18700 -0.131000 -0.134000 1.94e-01 1.83e-01
Dectin-2 family 19 3.39e-01 4.35e-01 0.23800 0.139000 0.193000 2.94e-01 1.46e-01
Plasma lipoprotein assembly 10 3.41e-01 4.38e-01 0.26900 0.085500 0.255000 6.39e-01 1.63e-01
mRNA 3’-end processing 56 3.42e-01 4.38e-01 0.12100 0.111000 0.047600 1.52e-01 5.38e-01
SUMOylation of ubiquitinylation proteins 39 3.44e-01 4.40e-01 0.12500 -0.026400 -0.122000 7.76e-01 1.87e-01
SUMOylation of DNA damage response and repair proteins 77 3.44e-01 4.40e-01 0.11300 -0.058500 -0.096200 3.75e-01 1.44e-01
Processing of Capped Intronless Pre-mRNA 28 3.45e-01 4.40e-01 0.17700 0.158000 0.079200 1.47e-01 4.68e-01
SUMO E3 ligases SUMOylate target proteins 159 3.47e-01 4.43e-01 0.06820 -0.064200 -0.023200 1.63e-01 6.13e-01
Diseases of DNA repair 10 3.48e-01 4.43e-01 0.32600 -0.261000 -0.195000 1.53e-01 2.86e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 3.48e-01 4.43e-01 0.18300 -0.112000 -0.145000 2.73e-01 1.56e-01
Downregulation of ERBB2 signaling 24 3.50e-01 4.45e-01 0.18500 0.077400 0.168000 5.12e-01 1.53e-01
Negative regulation of NMDA receptor-mediated neuronal transmission 14 3.51e-01 4.46e-01 0.23900 -0.095200 -0.219000 5.38e-01 1.56e-01
p75NTR recruits signalling complexes 12 3.53e-01 4.48e-01 0.28200 0.241000 0.148000 1.49e-01 3.75e-01
Laminin interactions 21 3.53e-01 4.49e-01 0.19000 0.071200 0.177000 5.72e-01 1.61e-01
ABC transporters in lipid homeostasis 14 3.57e-01 4.53e-01 0.19300 -0.025000 -0.191000 8.71e-01 2.15e-01
Activation of NMDA receptors and postsynaptic events 58 3.58e-01 4.53e-01 0.13200 0.076600 0.108000 3.13e-01 1.56e-01
Viral Messenger RNA Synthesis 44 3.60e-01 4.56e-01 0.08960 0.018500 -0.087600 8.32e-01 3.14e-01
Glutathione synthesis and recycling 10 3.61e-01 4.56e-01 0.24200 0.236000 0.052500 1.96e-01 7.74e-01
FOXO-mediated transcription of cell death genes 16 3.61e-01 4.56e-01 0.17300 0.013300 0.173000 9.26e-01 2.31e-01
Intraflagellar transport 39 3.61e-01 4.56e-01 0.15900 -0.131000 -0.088800 1.56e-01 3.37e-01
Synthesis of PIPs at the early endosome membrane 16 3.64e-01 4.59e-01 0.13600 -0.059100 0.122000 6.83e-01 3.97e-01
Regulation of localization of FOXO transcription factors 12 3.67e-01 4.62e-01 0.15000 -0.101000 0.111000 5.45e-01 5.06e-01
SHC-mediated cascade:FGFR1 12 3.67e-01 4.62e-01 0.24900 0.230000 0.095700 1.67e-01 5.66e-01
Downstream signaling of activated FGFR2 19 3.70e-01 4.65e-01 0.15700 0.157000 0.011700 2.37e-01 9.29e-01
Cell-Cell communication 88 3.70e-01 4.65e-01 0.09500 0.040600 0.085900 5.11e-01 1.64e-01
Meiotic recombination 38 3.71e-01 4.65e-01 0.14400 0.061600 0.130000 5.11e-01 1.64e-01
Sema3A PAK dependent Axon repulsion 16 3.74e-01 4.69e-01 0.21000 0.196000 0.075500 1.75e-01 6.01e-01
Nucleotide Excision Repair 110 3.76e-01 4.71e-01 0.09700 0.064100 0.072800 2.46e-01 1.87e-01
RUNX3 regulates p14-ARF 10 3.78e-01 4.73e-01 0.19200 -0.022000 0.190000 9.04e-01 2.97e-01
Signaling by FGFR4 in disease 11 3.80e-01 4.76e-01 0.22900 0.222000 0.054900 2.03e-01 7.53e-01
Neurexins and neuroligins 35 3.81e-01 4.76e-01 0.16700 -0.102000 -0.133000 2.97e-01 1.74e-01
Downstream signaling of activated FGFR1 20 3.81e-01 4.76e-01 0.21300 0.179000 0.115000 1.65e-01 3.75e-01
Cytochrome P450 - arranged by substrate type 32 3.83e-01 4.77e-01 0.15600 0.140000 0.067600 1.70e-01 5.08e-01
Interleukin-27 signaling 11 3.83e-01 4.78e-01 0.30400 0.205000 0.224000 2.39e-01 1.98e-01
CTLA4 inhibitory signaling 21 3.84e-01 4.78e-01 0.15600 -0.154000 -0.026500 2.22e-01 8.34e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 3.86e-01 4.80e-01 0.12300 0.081800 -0.091500 5.59e-01 5.14e-01
CD28 co-stimulation 33 3.91e-01 4.86e-01 0.14000 -0.132000 -0.046800 1.90e-01 6.42e-01
Nuclear Envelope Breakdown 53 3.93e-01 4.88e-01 0.08230 0.008170 -0.081900 9.18e-01 3.03e-01
Nicotinamide salvaging 14 3.95e-01 4.90e-01 0.13900 0.061700 -0.124000 6.89e-01 4.20e-01
G alpha (i) signalling events 243 4.00e-01 4.96e-01 0.06340 0.042100 0.047400 2.58e-01 2.04e-01
Transcriptional regulation by small RNAs 63 4.02e-01 4.98e-01 0.11300 0.056800 0.098300 4.36e-01 1.77e-01
SUMOylation 165 4.03e-01 4.99e-01 0.06370 -0.059100 -0.023700 1.90e-01 5.99e-01
MicroRNA (miRNA) biogenesis 24 4.11e-01 5.08e-01 0.19600 0.124000 0.152000 2.93e-01 1.99e-01
Post NMDA receptor activation events 48 4.13e-01 5.10e-01 0.12600 0.059800 0.111000 4.73e-01 1.85e-01
DAG and IP3 signaling 33 4.14e-01 5.10e-01 0.10700 -0.000912 0.107000 9.93e-01 2.89e-01
GP1b-IX-V activation signalling 10 4.14e-01 5.10e-01 0.26200 0.108000 0.239000 5.53e-01 1.91e-01
Carnitine metabolism 10 4.16e-01 5.11e-01 0.30600 0.212000 0.220000 2.46e-01 2.28e-01
CaM pathway 27 4.16e-01 5.11e-01 0.16600 0.078500 0.147000 4.80e-01 1.87e-01
Calmodulin induced events 27 4.16e-01 5.11e-01 0.16600 0.078500 0.147000 4.80e-01 1.87e-01
Defects in cobalamin (B12) metabolism 13 4.17e-01 5.12e-01 0.13700 0.072900 -0.116000 6.49e-01 4.69e-01
RNA Polymerase I Transcription Termination 27 4.17e-01 5.12e-01 0.12500 0.124000 0.011700 2.63e-01 9.16e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 4.23e-01 5.19e-01 0.14900 0.149000 0.002520 2.88e-01 9.86e-01
Dual Incision in GG-NER 41 4.25e-01 5.20e-01 0.08540 0.016800 -0.083700 8.52e-01 3.54e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 4.25e-01 5.20e-01 0.11100 0.095300 0.056500 1.91e-01 4.38e-01
RUNX2 regulates osteoblast differentiation 17 4.25e-01 5.20e-01 0.15500 -0.154000 -0.013200 2.71e-01 9.25e-01
Defects in vitamin and cofactor metabolism 21 4.26e-01 5.20e-01 0.18900 -0.093600 -0.165000 4.58e-01 1.92e-01
Metabolic disorders of biological oxidation enzymes 23 4.28e-01 5.22e-01 0.19200 0.155000 0.115000 2.00e-01 3.42e-01
Vitamin B5 (pantothenate) metabolism 17 4.30e-01 5.25e-01 0.23000 0.162000 0.163000 2.48e-01 2.43e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 4.32e-01 5.27e-01 0.24200 0.184000 0.157000 2.17e-01 2.92e-01
IRF3-mediated induction of type I IFN 12 4.33e-01 5.27e-01 0.15000 0.144000 -0.042800 3.88e-01 7.97e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 4.34e-01 5.28e-01 0.15300 0.122000 0.091800 2.04e-01 3.41e-01
RUNX2 regulates bone development 22 4.35e-01 5.28e-01 0.10100 -0.080000 0.062300 5.16e-01 6.13e-01
TICAM1,TRAF6-dependent induction of TAK1 complex 11 4.35e-01 5.28e-01 0.28100 0.215000 0.182000 2.18e-01 2.97e-01
Deactivation of the beta-catenin transactivating complex 36 4.35e-01 5.28e-01 0.09000 -0.088300 0.017300 3.59e-01 8.57e-01
Translation of structural proteins 28 4.37e-01 5.30e-01 0.09790 -0.027600 0.093900 8.01e-01 3.90e-01
O-linked glycosylation 81 4.38e-01 5.30e-01 0.10400 -0.078500 -0.067600 2.22e-01 2.93e-01
Bile acid and bile salt metabolism 28 4.38e-01 5.30e-01 0.11100 -0.002730 0.111000 9.80e-01 3.10e-01
Dual incision in TC-NER 65 4.39e-01 5.30e-01 0.10800 0.092100 0.056000 1.99e-01 4.35e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 4.39e-01 5.30e-01 0.10300 0.082500 0.062200 2.08e-01 3.43e-01
G0 and Early G1 27 4.40e-01 5.31e-01 0.09840 0.093700 -0.030100 3.99e-01 7.87e-01
O-linked glycosylation of mucins 46 4.49e-01 5.41e-01 0.13600 0.092600 0.099600 2.77e-01 2.43e-01
VEGFR2 mediated vascular permeability 26 4.50e-01 5.42e-01 0.09230 -0.049900 0.077700 6.60e-01 4.93e-01
NCAM signaling for neurite out-growth 43 4.51e-01 5.43e-01 0.11400 -0.039900 -0.107000 6.51e-01 2.24e-01
Diseases associated with N-glycosylation of proteins 17 4.52e-01 5.43e-01 0.19600 0.175000 0.087200 2.11e-01 5.34e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 4.52e-01 5.43e-01 0.20100 0.143000 0.140000 2.55e-01 2.66e-01
Association of TriC/CCT with target proteins during biosynthesis 37 4.54e-01 5.45e-01 0.15100 0.110000 0.103000 2.49e-01 2.76e-01
Metabolism of vitamins and cofactors 156 4.55e-01 5.45e-01 0.07290 0.055600 0.047100 2.31e-01 3.10e-01
Carboxyterminal post-translational modifications of tubulin 26 4.56e-01 5.46e-01 0.15900 0.072300 0.141000 5.23e-01 2.13e-01
ZBP1(DAI) mediated induction of type I IFNs 20 4.63e-01 5.54e-01 0.18800 0.098600 0.160000 4.45e-01 2.15e-01
RAS processing 19 4.67e-01 5.58e-01 0.20700 0.148000 0.144000 2.64e-01 2.76e-01
Downregulation of TGF-beta receptor signaling 26 4.68e-01 5.60e-01 0.13300 0.034000 0.129000 7.64e-01 2.56e-01
Heparan sulfate/heparin (HS-GAG) metabolism 37 4.70e-01 5.61e-01 0.08110 -0.023700 0.077500 8.03e-01 4.14e-01
Regulation of beta-cell development 19 4.70e-01 5.61e-01 0.11200 -0.106000 0.036300 4.26e-01 7.84e-01
RUNX3 regulates NOTCH signaling 14 4.73e-01 5.63e-01 0.13400 -0.031700 0.130000 8.37e-01 3.98e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 4.74e-01 5.64e-01 0.12100 0.029500 -0.118000 8.33e-01 4.01e-01
Serotonin Neurotransmitter Release Cycle 14 4.74e-01 5.64e-01 0.23200 -0.139000 -0.185000 3.68e-01 2.30e-01
Protein-protein interactions at synapses 55 4.76e-01 5.65e-01 0.11600 -0.093700 -0.068800 2.29e-01 3.78e-01
Acyl chain remodelling of PE 20 4.81e-01 5.71e-01 0.19700 0.136000 0.143000 2.93e-01 2.68e-01
Gene Silencing by RNA 88 4.82e-01 5.71e-01 0.07330 0.070100 0.021500 2.56e-01 7.27e-01
Termination of O-glycan biosynthesis 16 4.84e-01 5.73e-01 0.11800 -0.111000 0.040900 4.42e-01 7.77e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 4.84e-01 5.73e-01 0.15600 0.027200 0.154000 8.51e-01 2.86e-01
Mitochondrial tRNA aminoacylation 21 4.85e-01 5.74e-01 0.16300 -0.066600 -0.149000 5.97e-01 2.37e-01
Telomere Maintenance 80 4.85e-01 5.74e-01 0.05810 0.057700 -0.007370 3.73e-01 9.09e-01
Activation of kainate receptors upon glutamate binding 25 4.89e-01 5.78e-01 0.16800 0.097900 0.137000 3.97e-01 2.37e-01
PI3K events in ERBB2 signaling 11 4.93e-01 5.82e-01 0.26000 0.170000 0.196000 3.28e-01 2.60e-01
Dopamine Neurotransmitter Release Cycle 19 4.98e-01 5.87e-01 0.15600 -0.048600 -0.148000 7.14e-01 2.63e-01
IL-6-type cytokine receptor ligand interactions 12 4.98e-01 5.87e-01 0.12600 0.102000 -0.074200 5.42e-01 6.56e-01
Amino acid transport across the plasma membrane 23 5.00e-01 5.88e-01 0.15800 0.141000 0.070800 2.42e-01 5.57e-01
Meiosis 68 5.00e-01 5.88e-01 0.07120 0.008090 0.070700 9.08e-01 3.13e-01
Regulation of innate immune responses to cytosolic DNA 14 5.06e-01 5.94e-01 0.11600 0.062800 -0.098000 6.84e-01 5.26e-01
Depolymerisation of the Nuclear Lamina 15 5.07e-01 5.96e-01 0.20600 0.112000 0.173000 4.53e-01 2.45e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 5.09e-01 5.97e-01 0.20300 -0.076100 -0.188000 6.48e-01 2.59e-01
Interleukin-20 family signaling 17 5.12e-01 6.00e-01 0.18500 0.162000 0.090200 2.48e-01 5.19e-01
Peptide ligand-binding receptors 95 5.15e-01 6.02e-01 0.07560 0.067800 0.033300 2.53e-01 5.75e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 5.15e-01 6.03e-01 0.13100 -0.002820 -0.131000 9.84e-01 3.50e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 5.16e-01 6.03e-01 0.20900 -0.077000 -0.194000 6.58e-01 2.64e-01
Non-integrin membrane-ECM interactions 37 5.18e-01 6.05e-01 0.09620 0.014300 0.095100 8.80e-01 3.17e-01
Metabolism of nitric oxide: NOS3 activation and regulation 12 5.18e-01 6.05e-01 0.24100 0.163000 0.177000 3.27e-01 2.88e-01
Defective B4GALT7 causes EDS, progeroid type 11 5.19e-01 6.05e-01 0.19900 -0.062700 -0.189000 7.19e-01 2.77e-01
WNT ligand biogenesis and trafficking 21 5.20e-01 6.06e-01 0.15600 0.065600 0.142000 6.03e-01 2.60e-01
Signaling by Activin 10 5.21e-01 6.06e-01 0.16500 0.004660 -0.164000 9.80e-01 3.68e-01
Cyclin D associated events in G1 47 5.24e-01 6.08e-01 0.12000 0.091500 0.077800 2.78e-01 3.56e-01
G1 Phase 47 5.24e-01 6.08e-01 0.12000 0.091500 0.077800 2.78e-01 3.56e-01
Signaling by KIT in disease 20 5.25e-01 6.09e-01 0.09300 0.064100 -0.067400 6.20e-01 6.02e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 5.25e-01 6.09e-01 0.09300 0.064100 -0.067400 6.20e-01 6.02e-01
Adherens junctions interactions 18 5.26e-01 6.10e-01 0.11100 -0.109000 0.023100 4.25e-01 8.65e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 5.26e-01 6.10e-01 0.14400 -0.002710 0.144000 9.87e-01 3.69e-01
Lysosphingolipid and LPA receptors 11 5.29e-01 6.12e-01 0.19800 -0.064800 -0.188000 7.10e-01 2.82e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 5.33e-01 6.16e-01 0.18300 -0.110000 -0.146000 4.05e-01 2.71e-01
Phase 4 - resting membrane potential 10 5.40e-01 6.23e-01 0.19300 0.187000 0.049200 3.06e-01 7.88e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 5.41e-01 6.23e-01 0.15000 -0.122000 -0.087400 2.73e-01 4.32e-01
Attenuation phase 23 5.41e-01 6.23e-01 0.15800 0.133000 0.084900 2.68e-01 4.81e-01
Regulation of TP53 Activity through Methylation 19 5.41e-01 6.23e-01 0.18100 -0.109000 -0.144000 4.11e-01 2.77e-01
Cellular hexose transport 15 5.42e-01 6.23e-01 0.20700 -0.136000 -0.156000 3.61e-01 2.95e-01
Molecules associated with elastic fibres 21 5.43e-01 6.25e-01 0.14100 0.046100 0.133000 7.15e-01 2.92e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 5.44e-01 6.25e-01 0.11000 0.044900 -0.100000 7.63e-01 5.02e-01
RIP-mediated NFkB activation via ZBP1 17 5.45e-01 6.26e-01 0.18900 0.113000 0.152000 4.19e-01 2.79e-01
Class A/1 (Rhodopsin-like receptors) 166 5.46e-01 6.27e-01 0.03830 0.002260 -0.038300 9.60e-01 3.95e-01
Xenobiotics 11 5.47e-01 6.27e-01 0.17800 0.174000 0.039100 3.19e-01 8.22e-01
Repression of WNT target genes 14 5.49e-01 6.29e-01 0.21300 -0.141000 -0.159000 3.61e-01 3.03e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 5.51e-01 6.31e-01 0.15000 -0.111000 -0.101000 3.08e-01 3.56e-01
GPCR ligand binding 231 5.53e-01 6.32e-01 0.03850 -0.008240 -0.037600 8.29e-01 3.25e-01
Cell junction organization 59 5.56e-01 6.35e-01 0.09980 0.059100 0.080400 4.33e-01 2.85e-01
Interleukin-2 family signaling 38 5.64e-01 6.42e-01 0.11800 0.100000 0.061500 2.84e-01 5.12e-01
Lysine catabolism 11 5.64e-01 6.42e-01 0.12600 -0.118000 0.045600 4.99e-01 7.93e-01
IRAK2 mediated activation of TAK1 complex 10 5.64e-01 6.42e-01 0.24500 0.158000 0.187000 3.87e-01 3.06e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 5.67e-01 6.45e-01 0.22400 0.153000 0.164000 3.60e-01 3.26e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 5.68e-01 6.45e-01 0.08410 0.063900 0.054700 3.11e-01 3.86e-01
Nitric oxide stimulates guanylate cyclase 14 5.68e-01 6.45e-01 0.18600 0.088200 0.164000 5.68e-01 2.89e-01
TNF signaling 43 5.76e-01 6.54e-01 0.06070 0.053400 -0.028700 5.44e-01 7.45e-01
RAF-independent MAPK1/3 activation 21 5.77e-01 6.55e-01 0.14800 0.131000 0.068300 2.97e-01 5.88e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.79e-01 6.56e-01 0.10400 0.104000 -0.011600 4.34e-01 9.30e-01
Reproduction 80 5.79e-01 6.56e-01 0.07080 0.026400 0.065700 6.83e-01 3.10e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.83e-01 6.59e-01 0.12100 -0.121000 -0.007780 3.87e-01 9.56e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.83e-01 6.59e-01 0.12100 -0.121000 -0.007780 3.87e-01 9.56e-01
Phase 2 - plateau phase 11 5.86e-01 6.62e-01 0.22400 -0.140000 -0.175000 4.23e-01 3.16e-01
PECAM1 interactions 12 5.90e-01 6.67e-01 0.11700 -0.110000 0.039900 5.11e-01 8.11e-01
Synaptic adhesion-like molecules 15 5.93e-01 6.69e-01 0.10900 -0.106000 0.024100 4.76e-01 8.71e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 5.95e-01 6.71e-01 0.17900 0.094000 0.152000 5.28e-01 3.09e-01
DNA Damage Recognition in GG-NER 38 6.01e-01 6.77e-01 0.07710 0.002130 0.077100 9.82e-01 4.11e-01
NF-kB is activated and signals survival 12 6.02e-01 6.77e-01 0.20100 0.167000 0.111000 3.15e-01 5.06e-01
Class I peroxisomal membrane protein import 20 6.03e-01 6.78e-01 0.08790 -0.081900 0.031900 5.26e-01 8.05e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 6.05e-01 6.80e-01 0.13000 0.115000 0.059600 3.19e-01 6.06e-01
Diseases of metabolism 185 6.05e-01 6.80e-01 0.05150 0.042500 0.029200 3.19e-01 4.94e-01
Centrosome maturation 80 6.12e-01 6.85e-01 0.07570 -0.040300 -0.064100 5.33e-01 3.22e-01
Recruitment of mitotic centrosome proteins and complexes 80 6.12e-01 6.85e-01 0.07570 -0.040300 -0.064100 5.33e-01 3.22e-01
Synthesis of PIPs at the Golgi membrane 16 6.12e-01 6.85e-01 0.13200 0.028000 0.129000 8.46e-01 3.71e-01
Recruitment of NuMA to mitotic centrosomes 79 6.12e-01 6.85e-01 0.07830 -0.045400 -0.063800 4.85e-01 3.27e-01
Methylation 12 6.13e-01 6.85e-01 0.14200 0.141000 0.015600 3.98e-01 9.25e-01
PI-3K cascade:FGFR4 10 6.19e-01 6.92e-01 0.20900 0.179000 0.107000 3.28e-01 5.56e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 6.23e-01 6.95e-01 0.11500 0.096800 -0.061400 5.96e-01 7.37e-01
HS-GAG biosynthesis 20 6.24e-01 6.95e-01 0.12400 0.036700 0.118000 7.76e-01 3.60e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.26e-01 6.97e-01 0.07960 0.069900 0.038200 3.34e-01 5.97e-01
Regulation of KIT signaling 15 6.30e-01 7.02e-01 0.14000 0.039500 0.134000 7.91e-01 3.69e-01
RNA Polymerase I Transcription Initiation 44 6.34e-01 7.06e-01 0.10200 -0.062100 -0.081400 4.76e-01 3.50e-01
Defective B3GAT3 causes JDSSDHD 11 6.35e-01 7.07e-01 0.16300 -0.047900 -0.156000 7.83e-01 3.71e-01
Other semaphorin interactions 16 6.36e-01 7.07e-01 0.11200 0.002910 0.112000 9.84e-01 4.39e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 6.38e-01 7.08e-01 0.09400 0.053900 -0.077000 7.27e-01 6.18e-01
TRAF3-dependent IRF activation pathway 13 6.41e-01 7.11e-01 0.16600 0.150000 0.072600 3.50e-01 6.51e-01
Maturation of nucleoprotein 10 6.42e-01 7.11e-01 0.21200 -0.128000 -0.168000 4.83e-01 3.56e-01
Nicotinate metabolism 25 6.50e-01 7.20e-01 0.06800 0.046200 -0.049900 6.89e-01 6.66e-01
Voltage gated Potassium channels 24 6.54e-01 7.24e-01 0.08690 -0.000413 0.086900 9.97e-01 4.61e-01
IGF1R signaling cascade 36 6.56e-01 7.25e-01 0.10700 0.060100 0.087900 5.32e-01 3.61e-01
Visual phototransduction 59 6.59e-01 7.28e-01 0.04560 -0.019400 0.041300 7.97e-01 5.84e-01
Cilium Assembly 180 6.66e-01 7.34e-01 0.04690 -0.026300 -0.038800 5.43e-01 3.69e-01
Polo-like kinase mediated events 15 6.66e-01 7.34e-01 0.16600 0.101000 0.132000 4.98e-01 3.78e-01
Cytosolic sensors of pathogen-associated DNA 62 6.68e-01 7.36e-01 0.07450 0.065700 0.035000 3.71e-01 6.33e-01
DNA Double-Strand Break Repair 135 6.70e-01 7.38e-01 0.05610 -0.037400 -0.041800 4.53e-01 4.02e-01
Synthesis of bile acids and bile salts 24 6.72e-01 7.39e-01 0.10200 0.028600 0.098200 8.08e-01 4.05e-01
Anchoring of the basal body to the plasma membrane 96 6.77e-01 7.44e-01 0.06470 -0.040200 -0.050700 4.96e-01 3.91e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 6.78e-01 7.45e-01 0.06470 -0.058100 0.028500 6.01e-01 7.97e-01
Signaling by NTRK3 (TRKC) 15 6.81e-01 7.47e-01 0.13000 0.124000 0.040300 4.07e-01 7.87e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 6.84e-01 7.50e-01 0.14900 0.145000 0.034300 4.27e-01 8.51e-01
Receptor-type tyrosine-protein phosphatases 11 6.89e-01 7.55e-01 0.14900 -0.142000 -0.045200 4.15e-01 7.95e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 6.90e-01 7.56e-01 0.13800 0.049800 0.129000 7.47e-01 4.05e-01
PI-3K cascade:FGFR1 12 6.92e-01 7.57e-01 0.17500 0.103000 0.141000 5.38e-01 3.97e-01
Basigin interactions 22 6.93e-01 7.58e-01 0.13100 0.083000 0.102000 5.00e-01 4.09e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 6.94e-01 7.58e-01 0.15100 -0.041300 -0.145000 8.21e-01 4.26e-01
Defective EXT2 causes exostoses 2 10 6.94e-01 7.58e-01 0.15100 -0.041300 -0.145000 8.21e-01 4.26e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 6.95e-01 7.58e-01 0.12200 0.109000 0.053900 3.98e-01 6.76e-01
Processing of Intronless Pre-mRNAs 19 6.95e-01 7.58e-01 0.14300 0.100000 0.102000 4.50e-01 4.42e-01
Regulation of TP53 Activity through Phosphorylation 88 6.98e-01 7.60e-01 0.04170 0.000461 -0.041700 9.94e-01 4.99e-01
Activation of RAC1 11 7.00e-01 7.61e-01 0.18600 0.125000 0.137000 4.72e-01 4.32e-01
Signaling by Retinoic Acid 31 7.00e-01 7.61e-01 0.09780 0.087100 0.044300 4.01e-01 6.69e-01
Metabolism of water-soluble vitamins and cofactors 110 7.03e-01 7.64e-01 0.03470 0.034400 -0.004330 5.33e-01 9.37e-01
Fertilization 12 7.06e-01 7.66e-01 0.13500 0.130000 0.036900 4.37e-01 8.25e-01
RHO GTPases Activate Formins 117 7.06e-01 7.66e-01 0.03380 -0.003390 0.033700 9.49e-01 5.29e-01
Degradation of cysteine and homocysteine 12 7.08e-01 7.67e-01 0.17300 0.109000 0.134000 5.12e-01 4.23e-01
Synthesis of PA 32 7.13e-01 7.72e-01 0.07480 0.012000 0.073800 9.06e-01 4.70e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 7.14e-01 7.72e-01 0.16500 0.125000 0.107000 4.35e-01 5.03e-01
NOTCH2 intracellular domain regulates transcription 11 7.15e-01 7.73e-01 0.10900 -0.009380 0.108000 9.57e-01 5.34e-01
MET activates PTK2 signaling 15 7.19e-01 7.76e-01 0.10500 0.012100 0.104000 9.36e-01 4.86e-01
Norepinephrine Neurotransmitter Release Cycle 14 7.25e-01 7.82e-01 0.11600 -0.026800 -0.113000 8.62e-01 4.64e-01
Adrenaline,noradrenaline inhibits insulin secretion 24 7.29e-01 7.86e-01 0.11600 0.091600 0.070700 4.37e-01 5.49e-01
Glucagon-type ligand receptors 20 7.30e-01 7.87e-01 0.06960 0.065100 -0.024500 6.14e-01 8.50e-01
IRS-related events triggered by IGF1R 35 7.34e-01 7.91e-01 0.09270 0.052700 0.076200 5.90e-01 4.35e-01
FOXO-mediated transcription 59 7.35e-01 7.91e-01 0.04880 0.002470 0.048800 9.74e-01 5.17e-01
RNA Polymerase III Transcription Termination 23 7.37e-01 7.92e-01 0.09840 0.091400 0.036400 4.48e-01 7.62e-01
SUMOylation of DNA methylation proteins 16 7.38e-01 7.93e-01 0.09900 -0.098000 -0.014300 4.97e-01 9.21e-01
Interleukin receptor SHC signaling 23 7.39e-01 7.94e-01 0.11600 0.090500 0.073300 4.53e-01 5.43e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 7.41e-01 7.94e-01 0.10500 0.049800 0.092900 6.79e-01 4.40e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 7.42e-01 7.94e-01 0.13800 -0.119000 -0.070000 4.39e-01 6.50e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 7.42e-01 7.94e-01 0.13800 -0.119000 -0.070000 4.39e-01 6.50e-01
Diseases associated with glycosaminoglycan metabolism 25 7.43e-01 7.95e-01 0.05800 -0.028800 0.050300 8.03e-01 6.63e-01
Ovarian tumor domain proteases 37 7.47e-01 7.99e-01 0.07180 0.068400 0.021600 4.71e-01 8.20e-01
Ephrin signaling 17 7.51e-01 8.02e-01 0.12500 0.066100 0.106000 6.37e-01 4.50e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 7.52e-01 8.02e-01 0.08120 0.073800 0.033900 4.57e-01 7.32e-01
Establishment of Sister Chromatid Cohesion 11 7.52e-01 8.02e-01 0.16400 0.126000 0.106000 4.70e-01 5.44e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 7.53e-01 8.02e-01 0.12700 0.042200 0.120000 8.00e-01 4.71e-01
mRNA decay by 5’ to 3’ exoribonuclease 15 7.55e-01 8.04e-01 0.11100 0.106000 0.034600 4.77e-01 8.17e-01
Interaction between L1 and Ankyrins 20 7.56e-01 8.04e-01 0.09690 -0.091800 -0.031100 4.77e-01 8.10e-01
DAP12 signaling 28 7.56e-01 8.04e-01 0.05220 -0.042000 0.030900 7.00e-01 7.77e-01
G2/M DNA damage checkpoint 67 7.58e-01 8.05e-01 0.04300 0.043000 0.001350 5.43e-01 9.85e-01
PI3K Cascade 30 7.62e-01 8.09e-01 0.06280 0.000823 0.062800 9.94e-01 5.52e-01
Mitotic Spindle Checkpoint 108 7.71e-01 8.17e-01 0.03190 0.031900 -0.000500 5.66e-01 9.93e-01
Acyl chain remodelling of PS 14 7.74e-01 8.21e-01 0.13800 0.089700 0.105000 5.61e-01 4.95e-01
TRAF6 mediated IRF7 activation 15 7.75e-01 8.21e-01 0.13400 0.099400 0.090000 5.05e-01 5.46e-01
IRS-mediated signalling 34 7.77e-01 8.23e-01 0.08740 0.054700 0.068100 5.81e-01 4.92e-01
Activation of BH3-only proteins 30 7.80e-01 8.25e-01 0.07230 0.069500 0.020300 5.10e-01 8.48e-01
Signaling by NODAL 13 7.85e-01 8.29e-01 0.13600 -0.110000 -0.080500 4.92e-01 6.15e-01
G alpha (s) signalling events 137 7.87e-01 8.31e-01 0.04150 0.034000 0.023800 4.92e-01 6.30e-01
DCC mediated attractive signaling 13 7.88e-01 8.31e-01 0.09320 -0.092900 -0.007350 5.62e-01 9.63e-01
Homology Directed Repair 110 7.88e-01 8.31e-01 0.04630 -0.026800 -0.037700 6.27e-01 4.94e-01
HCMV Early Events 74 7.90e-01 8.31e-01 0.03480 -0.003830 0.034600 9.55e-01 6.07e-01
Loss of Nlp from mitotic centrosomes 68 7.90e-01 8.31e-01 0.06060 -0.044700 -0.041000 5.24e-01 5.59e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 7.90e-01 8.31e-01 0.06060 -0.044700 -0.041000 5.24e-01 5.59e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 7.98e-01 8.39e-01 0.08010 0.052700 0.060300 5.79e-01 5.26e-01
Signaling by NOTCH2 30 8.05e-01 8.45e-01 0.08750 0.064800 0.058900 5.39e-01 5.77e-01
Sulfur amino acid metabolism 22 8.05e-01 8.45e-01 0.10200 0.076800 0.066600 5.33e-01 5.88e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 8.08e-01 8.47e-01 0.10700 -0.098300 -0.041200 5.24e-01 7.90e-01
SLC transporter disorders 75 8.09e-01 8.47e-01 0.02970 0.028000 -0.010000 6.75e-01 8.81e-01
HSF1-dependent transactivation 29 8.13e-01 8.51e-01 0.06240 0.061400 0.011400 5.67e-01 9.15e-01
Blood group systems biosynthesis 17 8.13e-01 8.51e-01 0.10700 0.089900 0.058200 5.21e-01 6.78e-01
PI-3K cascade:FGFR2 12 8.16e-01 8.53e-01 0.06850 0.037700 -0.057200 8.21e-01 7.32e-01
Mitotic Prometaphase 184 8.18e-01 8.55e-01 0.03010 -0.013600 -0.026900 7.51e-01 5.29e-01
ADORA2B mediated anti-inflammatory cytokines production 72 8.23e-01 8.59e-01 0.03150 0.031200 -0.004490 6.47e-01 9.47e-01
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 8.32e-01 8.67e-01 0.09680 0.024800 0.093500 8.82e-01 5.75e-01
Regulation of FZD by ubiquitination 15 8.33e-01 8.68e-01 0.09360 -0.033800 -0.087300 8.20e-01 5.58e-01
Transcriptional Regulation by VENTX 38 8.38e-01 8.73e-01 0.03580 -0.029900 0.019700 7.50e-01 8.33e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 8.46e-01 8.79e-01 0.06650 0.049800 0.044100 5.86e-01 6.29e-01
Nucleosome assembly 40 8.46e-01 8.79e-01 0.06650 0.049800 0.044100 5.86e-01 6.29e-01
Base Excision Repair 58 8.64e-01 8.97e-01 0.04480 -0.019100 -0.040600 8.02e-01 5.93e-01
CDC6 association with the ORC:origin complex 11 8.64e-01 8.97e-01 0.06020 0.048600 -0.035600 7.80e-01 8.38e-01
DNA Repair 289 8.67e-01 8.99e-01 0.02230 -0.018100 -0.013000 5.97e-01 7.04e-01
Condensation of Prometaphase Chromosomes 11 8.68e-01 9.00e-01 0.08840 0.022400 0.085500 8.97e-01 6.23e-01
Lewis blood group biosynthesis 13 8.69e-01 9.00e-01 0.06990 -0.069800 -0.003170 6.63e-01 9.84e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 8.73e-01 9.03e-01 0.03510 -0.018400 0.029900 8.60e-01 7.73e-01
Processing of DNA double-strand break ends 71 8.75e-01 9.05e-01 0.03810 0.034800 0.015500 6.12e-01 8.21e-01
Nef mediated downregulation of MHC class I complex cell surface expression 10 8.79e-01 9.08e-01 0.11500 0.071300 0.090300 6.96e-01 6.21e-01
Cell-cell junction organization 38 8.89e-01 9.18e-01 0.03450 0.003410 -0.034300 9.71e-01 7.15e-01
AURKA Activation by TPX2 71 8.91e-01 9.19e-01 0.04040 -0.032600 -0.023900 6.35e-01 7.27e-01
Resolution of Sister Chromatid Cohesion 104 8.93e-01 9.20e-01 0.02870 0.026400 0.011100 6.42e-01 8.45e-01
RNA Polymerase III Transcription Initiation 36 8.93e-01 9.20e-01 0.04630 -0.043700 -0.015200 6.50e-01 8.74e-01
Nucleotide-like (purinergic) receptors 13 8.94e-01 9.20e-01 0.06950 -0.068100 -0.013900 6.71e-01 9.31e-01
Signaling by BMP 21 8.98e-01 9.23e-01 0.04100 0.039500 -0.011000 7.54e-01 9.30e-01
TRP channels 17 8.99e-01 9.23e-01 0.07570 -0.064700 -0.039200 6.44e-01 7.80e-01
Regulation of PLK1 Activity at G2/M Transition 86 8.99e-01 9.23e-01 0.02020 0.005360 -0.019500 9.32e-01 7.55e-01
Kinesins 39 9.01e-01 9.25e-01 0.04430 -0.041100 -0.016700 6.57e-01 8.57e-01
Constitutive Signaling by Aberrant PI3K in Cancer 53 9.06e-01 9.29e-01 0.02300 -0.011400 0.020000 8.86e-01 8.01e-01
Other interleukin signaling 18 9.06e-01 9.29e-01 0.05080 0.050700 0.003900 7.10e-01 9.77e-01
RNA Polymerase III Chain Elongation 18 9.08e-01 9.29e-01 0.06130 -0.021000 -0.057600 8.77e-01 6.72e-01
Regulation of TP53 Degradation 35 9.09e-01 9.30e-01 0.03570 -0.035600 -0.002490 7.16e-01 9.80e-01
Diseases of glycosylation 106 9.14e-01 9.35e-01 0.02990 -0.022200 -0.020100 6.93e-01 7.21e-01
Pregnenolone biosynthesis 10 9.19e-01 9.39e-01 0.05210 0.049600 -0.015700 7.86e-01 9.31e-01
Branched-chain amino acid catabolism 21 9.22e-01 9.41e-01 0.04760 0.010900 0.046300 9.31e-01 7.13e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 9.25e-01 9.43e-01 0.03120 -0.010400 0.029400 9.28e-01 7.99e-01
Regulation of TP53 Expression and Degradation 36 9.28e-01 9.46e-01 0.04260 -0.037200 -0.020800 6.99e-01 8.29e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 9.32e-01 9.49e-01 0.06080 -0.030300 -0.052700 8.29e-01 7.07e-01
RNA Polymerase III Abortive And Retractive Initiation 41 9.37e-01 9.52e-01 0.03920 0.022200 0.032400 8.06e-01 7.20e-01
RNA Polymerase III Transcription 41 9.37e-01 9.52e-01 0.03920 0.022200 0.032400 8.06e-01 7.20e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 9.38e-01 9.52e-01 0.02130 -0.006200 -0.020300 9.19e-01 7.37e-01
Amplification of signal from the kinetochores 91 9.38e-01 9.52e-01 0.02130 -0.006200 -0.020300 9.19e-01 7.37e-01
CRMPs in Sema3A signaling 14 9.39e-01 9.52e-01 0.03500 0.021800 -0.027400 8.88e-01 8.59e-01
The phototransduction cascade 26 9.39e-01 9.52e-01 0.04470 -0.039900 -0.020100 7.25e-01 8.59e-01
Class B/2 (Secretin family receptors) 55 9.39e-01 9.52e-01 0.01910 -0.018200 0.005820 8.16e-01 9.41e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 9.42e-01 9.53e-01 0.04210 0.028800 0.030700 7.65e-01 7.50e-01
Diseases of mitotic cell cycle 36 9.42e-01 9.53e-01 0.04210 0.028800 0.030700 7.65e-01 7.50e-01
Netrin-1 signaling 40 9.55e-01 9.66e-01 0.02140 -0.001390 0.021400 9.88e-01 8.15e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.58e-01 9.68e-01 0.03230 0.002400 -0.032300 9.87e-01 8.23e-01
Interleukin-7 signaling 21 9.59e-01 9.68e-01 0.04270 0.022200 0.036500 8.60e-01 7.72e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 9.69e-01 9.77e-01 0.01990 0.016300 0.011500 8.03e-01 8.59e-01
Downregulation of ERBB2:ERBB3 signaling 12 9.73e-01 9.81e-01 0.04860 0.030500 0.037800 8.55e-01 8.20e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 9.74e-01 9.81e-01 0.03120 0.023400 0.020700 8.30e-01 8.50e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 9.75e-01 9.81e-01 0.01010 0.000370 -0.010100 9.95e-01 8.59e-01
Interleukin-2 signaling 11 9.77e-01 9.83e-01 0.04570 0.027600 0.036500 8.74e-01 8.34e-01
Interleukin-35 Signalling 12 9.79e-01 9.84e-01 0.04340 -0.031500 -0.029800 8.50e-01 8.58e-01
Telomere Extension By Telomerase 23 9.81e-01 9.85e-01 0.01530 0.012300 -0.008970 9.18e-01 9.41e-01
HS-GAG degradation 16 9.89e-01 9.92e-01 0.02710 0.017100 0.020900 9.05e-01 8.85e-01
Activation of SMO 13 9.91e-01 9.94e-01 0.02090 -0.019900 -0.006400 9.01e-01 9.68e-01
EML4 and NUDC in mitotic spindle formation 95 9.93e-01 9.95e-01 0.00464 0.001970 -0.004190 9.73e-01 9.44e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 9.93e-01 9.95e-01 0.02570 0.019000 0.017300 9.13e-01 9.21e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 9.96e-01 9.97e-01 0.01180 -0.009970 -0.006340 9.31e-01 9.56e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 9.99e-01 9.99e-01 0.00279 -0.002730 -0.000567 9.77e-01 9.95e-01


Detailed Gene set reports


Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 456
pMANOVA 5.75e-107
p.adjustMANOVA 7.84e-104
s.dist 0.76
s.low.CRP 0.536
s.high.CRP 0.539
p.low.CRP 3.01e-86
p.high.CRP 2.42e-87




Top 20 genes
Gene low CRP high CRP
RNASE2 10359 10657
IDH1 10341 10649
S100A12 10367 10617
MGST1 10318 10658
CTSA 10310 10636
SIRPA 10351 10576
S100A8 10362 10564
S100A9 10316 10598
MCEMP1 10355 10554
CD93 10231 10668
CR1 10309 10566
CD36 10363 10493
SERPINB1 10330 10507
PGAM1 10347 10422
HP 10242 10523
ATP6V0A1 10207 10551
LAMTOR1 10275 10468
FPR1 10352 10383
CREG1 10146 10578
PLD1 10119 10572

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201 6324
ABCA13 9337 4245
ACAA1 7355 9532
ACLY -3480 8333
ACTR10 9447 8995
ACTR1B -9174 -7104
ACTR2 9004 9240
ADAM10 9652 10284
ADAM8 1203 2391
ADGRE3 -6203 -8538
ADGRE5 -10156 -1430
ADGRG3 4594 7820
AGA -8931 1617
AGL -5887 971
AGPAT2 9571 10463
ALAD 5688 9906
ALDH3B1 9122 10008
ALDOA 10140 10121
ALDOC 3900 -6356
ALOX5 9735 9772
AMPD3 8883 9878
ANO6 7295 8568
ANPEP 10206 10073
ANXA2 9791 10138
AOC1 4561 3551
AP1M1 392 8050
AP2A2 5529 9467
APAF1 9662 9512
APEH -6699 1881
APRT 3186 -4197
ARG1 9516 8264
ARHGAP9 -4182 7692
ARL8A 9465 8775
ARMC8 9323 7367
ARPC5 9932 9762
ARSA 6282 1069
ARSB 8290 9046
ASAH1 9394 10144
ATAD3B -4315 -7816
ATG7 9954 8519
ATP11A 6284 9116
ATP11B -350 6286
ATP6AP2 9781 8803
ATP6V0A1 10207 10551
ATP6V0C 9621 9869
ATP6V1D 9919 9993
ATP8A1 -10266 -10371
ATP8B4 7565 8129
AZU1 9907 1592
B2M 58 -7420
B4GALT1 -3872 6820
BIN2 -8436 8915
BPI 9742 5505
BRI3 8728 10115
BST1 10348 10335
BST2 -3420 -6690
C3 -10957 -10571
C3AR1 8008 9376
C5AR1 9773 10201
C6orf120 5027 7382
CAB39 9229 8388
CAMP 4319 -2875
CAND1 1355 -1576
CANT1 6929 6926
CAP1 9134 8626
CAPN1 5416 9742
CAT 9642 9941
CCT2 6166 -5938
CCT8 9483 8073
CD14 10063 10306
CD177 9884 10435
CD300A -7444 -2295
CD33 9741 8810
CD36 10363 10493
CD44 9109 9660
CD47 -8631 -9598
CD53 7763 9356
CD55 9747 10312
CD58 8027 7845
CD59 6386 4199
CD63 9814 10489
CD68 9480 10077
CD93 10231 10668
CDA 10040 10360
CDK13 -10473 -1209
CEACAM1 8525 8200
CEACAM3 5874 4896
CEACAM6 9295 4203
CEACAM8 9490 3624
CEP290 515 -6593
CFD 911 -342
CFP 8398 8912
CHI3L1 6877 -4064
CHIT1 9419 6195
CKAP4 10349 9973
CLEC12A 7370 3483
CLEC4C -10672 -8976
CLEC4D 10190 9618
CLEC5A 9868 9360
CMTM6 9160 8256
CNN2 4530 6242
COMMD3 3550 2189
COMMD9 9687 9081
COPB1 9548 8670
COTL1 8714 9141
CPNE1 -7255 -6504
CPNE3 8631 6794
CPPED1 9095 9222
CR1 10309 10566
CRACR2A -10855 -4635
CREG1 10146 10578
CRISP3 5459 7621
CRISPLD2 9797 10342
CSNK2B 4787 4600
CST3 5014 -1198
CSTB 7160 8738
CTSA 10310 10636
CTSB 9828 10631
CTSC -3910 5638
CTSD 9997 10635
CTSG 9668 2004
CTSH 9551 7551
CTSS 10120 8325
CTSZ 9796 10451
CXCL1 7627 4227
CXCR1 3353 4270
CXCR2 5266 1302
CYB5R3 7459 10015
CYBA 5409 8122
CYBB 10294 9839
CYFIP1 10019 10571
CYSTM1 10132 9426
DBNL 4127 8290
DDOST 5768 8734
DDX3X 7864 5693
DEFA1 9522 5409
DEFA4 9728 4397
DEGS1 8935 6383
DERA 9456 9825
DGAT1 879 2318
DIAPH1 -9285 3050
DNAJC13 8999 9866
DNAJC3 9070 9215
DNAJC5 8864 9763
DNASE1L1 7707 10229
DOCK2 3702 9336
DOK3 10044 10449
DPP7 -979 -5002
DSC1 3313 -7945
DSN1 -8664 -5515
DSP -4419 -1253
DYNC1H1 -9811 -4718
DYNC1LI1 8227 7194
DYNLL1 6414 7208
DYNLT1 6878 3642
EEF1A1 2936 -4796
EEF2 -3419 -1260
ELANE 10082 5779
ENPP4 -10352 -5923
EPX 784 -848
ERP44 9756 6863
FABP5 6772 7102
FAF2 3745 8707
FCAR 10261 9489
FCER1G 9338 9547
FCGR2A 9647 9000
FCGR3B 5213 -2356
FCN1 10313 9522
FGL2 9767 -4215
FGR 7776 10127
FOLR3 8487 6843
FPR1 10352 10383
FPR2 10305 10056
FRK -3103 1427
FRMPD3 -10958 -9622
FTH1 1622 1016
FTL 9418 9788
FUCA1 9326 10044
FUCA2 9523 9365
GAA 8463 8516
GALNS 6891 7996
GCA 10340 10301
GDI2 8435 8742
GGH 7094 6779
GHDC 425 764
GLA 7742 9617
GLB1 9395 10125
GLIPR1 10116 7714
GM2A 9951 10624
GMFG 8707 8365
GNS 9753 10593
GOLGA7 5151 3331
GPI 3695 7384
GPR84 10189 9570
GRN 10105 10416
GSDMD 4103 -1714
GSN 10108 9436
GSTP1 2629 -1335
GUSB 3888 9979
GYG1 9967 10059
HBB 9671 6093
HEBP2 7929 9318
HEXB 9686 9967
HGSNAT 2790 2412
HK3 10197 10277
HLA-A -3294 -7605
HLA-B 5549 -2345
HLA-C 1664 -2812
HLA-H -8262 -1093
HMGB1 3409 1050
HMOX2 -9635 -10507
HP 10242 10523
HPSE 9308 10055
HRNR -8222 -7950
HSP90AA1 5650 1245
HSP90AB1 4616 -5342
HSPA1A 8518 7125
HSPA1B 4687 5369
HSPA6 4663 3881
HSPA8 -4222 -8984
HUWE1 -9990 -3993
HVCN1 5605 5771
IDH1 10341 10649
IGF2R -5530 9230
ILF2 6408 2915
IMPDH1 10166 10137
IMPDH2 543 -9049
IQGAP1 6734 9841
IQGAP2 3533 9892
IST1 2776 6310
ITGAL -10521 -8351
ITGAM 10114 10483
ITGAV 4141 7107
ITGAX 4703 8540
ITGB2 9132 10614
JUP -10174 -7667
KCMF1 5611 7491
KCNAB2 -9357 6982
KPNB1 67 557
KRT1 8174 5752
LAIR1 -2261 9900
LAMP1 1557 8684
LAMP2 9626 9234
LAMTOR1 10275 10468
LAMTOR2 6251 9811
LAMTOR3 9336 8131
LCN2 9492 6870
LGALS3 9840 9259
LILRB2 7666 10116
LILRB3 8925 10163
LPCAT1 -10615 -1283
LRG1 8829 9304
LRRC7 -2647 1172
LTA4H 10110 10291
LTF 9350 4940
LYZ 10158 5170
MAGT1 4037 5258
MAN2B1 6033 6605
MANBA 8844 7868
MAPK1 -1086 9427
MAPK14 10026 9803
MCEMP1 10355 10554
METTL7A 6476 8678
MGAM 9062 9613
MGST1 10318 10658
MIF -427 -5003
MLEC -220 4725
MME -3693 -8367
MMP25 7595 8922
MMP8 5024 9987
MMP9 8967 1371
MNDA 10302 9902
MOSPD2 10095 8658
MPO 10011 5205
MS4A3 8641 -1759
MVP 8914 6884
NAPRT 6733 8768
NBEAL2 4481 7538
NCKAP1L 1901 10162
NCSTN 9915 10361
NDUFC2 7348 9008
NEU1 9609 10026
NFAM1 9877 10409
NFKB1 8527 5403
NHLRC3 4425 7076
NIT2 -5470 -9344
NME2 5550 1269
NPC2 8648 6362
NRAS 8582 7708
OLFM4 4279 7865
OLR1 9142 -629
ORM1 9208 6694
ORM2 1731 -2088
ORMDL3 -10039 -8440
OSCAR 9873 9943
OSTF1 7593 8307
P2RX1 566 10417
PA2G4 5160 -928
PADI2 10200 10268
PAFAH1B2 7578 8153
PDAP1 3713 8107
PDXK 9531 9355
PECAM1 7190 9387
PFKL -4628 -3901
PGAM1 10347 10422
PGLYRP1 9124 7399
PGM1 2601 6092
PGM2 10212 10292
PGRMC1 6912 7496
PIGR 3970 5820
PKM 10317 10280
PLAC8 8969 10175
PLAU 4112 3352
PLAUR 9724 9965
PLD1 10119 10572
PLEKHO2 6402 8506
PNP 9592 9563
PPBP 5440 6001
PPIA 285 1417
PPIE -3976 -8580
PRCP 9464 9217
PRDX4 7205 2372
PRDX6 9478 8747
PRKCD 9710 9721
PRTN3 10009 6834
PSAP 8066 8239
PSEN1 7406 9055
PSMA2 9175 6486
PSMA5 6009 -5256
PSMB1 8548 3242
PSMB7 9346 8950
PSMC2 4967 6378
PSMC3 2824 4673
PSMD1 8509 8974
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD6 9864 9375
PSMD7 9212 6772
PTAFR 10084 10562
PTGES2 -4699 -4573
PTPN6 3230 7923
PTPRB -9309 -1901
PTPRC -4530 4553
PTPRJ 1010 9383
PTPRN2 7727 4489
PTX3 9712 4622
PYCARD 8846 9930
PYGB -6473 454
PYGL 10308 10199
QPCT 10273 10185
QSOX1 9888 10475
RAB10 9916 9959
RAB14 8765 8436
RAB18 9744 7495
RAB24 5628 2552
RAB27A 9159 9152
RAB31 10008 10290
RAB37 -10867 -10259
RAB3A 6440 9746
RAB3D 9091 10183
RAB44 6119 -1305
RAB4B -3971 4641
RAB5B -279 7773
RAB5C 8923 9415
RAB6A 8383 9332
RAB7A 9941 9609
RAB9B -6342 1453
RAC1 9345 9946
RAP1A 9691 8186
RAP1B -3254 7324
RAP2B -7124 -440
RAP2C 785 5615
RETN 10075 10034
RHOA 9541 9090
RHOF -10845 -10601
RHOG 8649 8946
RNASE2 10359 10657
RNASE3 10043 8604
RNASET2 5772 5567
ROCK1 5871 8890
S100A11 10016 9498
S100A12 10367 10617
S100A8 10362 10564
S100A9 10316 10598
S100P 8625 9159
SCAMP1 6325 2268
SDCBP 10246 10113
SELL 9795 9352
SERPINA1 10186 10295
SERPINB1 10330 10507
SERPINB10 10233 9723
SERPINB6 4741 9944
SIGLEC14 9432 1567
SIGLEC5 9147 7119
SIGLEC9 9906 10513
SIRPA 10351 10576
SIRPB1 7561 9956
SLC11A1 9804 10582
SLC15A4 -7633 6832
SLC27A2 8033 -6002
SLC2A3 10169 9727
SLC2A5 7318 181
SLC44A2 -3421 2167
SLCO4C1 -9301 4048
SLPI 9574 1116
SNAP23 9581 8746
SNAP29 -5542 9818
SPTAN1 -10045 -9563
SRP14 5097 7759
STBD1 6327 6394
STING1 8496 4759
STK10 -10751 -1875
STK11IP -4945 7132
STOM 2462 8162
SURF4 6833 7852
SVIP 3352 1164
SYNGR1 -5375 -4808
TARM1 9495 6302
TBC1D10C -10068 -10544
TCIRG1 253 9871
TCN1 9143 3640
TICAM2 9445 5256
TIMP2 10080 10603
TLR2 10239 9881
TMBIM1 8125 9006
TMC6 -6434 -9567
TMEM179B 5717 -1815
TMEM30A 9426 8525
TMEM63A -1855 -9668
TNFAIP6 9826 9521
TNFRSF1B -1892 8266
TOLLIP 8936 8482
TOM1 9316 10512
TRAPPC1 6932 9117
TRPM2 9977 10050
TSPAN14 -3505 8543
TUBB -6747 -3278
TUBB4B 7592 5692
TXNDC5 5836 -3635
TYROBP 6739 8642
UBR4 -9246 -21
UNC13D -69 8894
VAMP8 7797 7239
VAPA 9859 9626
VAT1 9646 10524
VCL 913 8321
VCP 7591 6702
VNN1 10163 10414
VPS35L 6316 8792
XRCC5 7806 6087
XRCC6 6022 -236
YPEL5 5177 5140



Innate Immune System

Innate Immune System
metric value
setSize 963
pMANOVA 8.82e-86
p.adjustMANOVA 6.01e-83
s.dist 0.47
s.low.CRP 0.357
s.high.CRP 0.306
p.low.CRP 4.15e-79
p.high.CRP 2.68e-58




Top 20 genes
Gene low CRP high CRP
RNASE2 10359 10657
IDH1 10341 10649
S100A12 10367 10617
MGST1 10318 10658
CTSA 10310 10636
WASF1 10267 10673
SIRPA 10351 10576
S100A8 10362 10564
S100A9 10316 10598
MCEMP1 10355 10554
CD93 10231 10668
CR1 10309 10566
CD36 10363 10493
SERPINB1 10330 10507
CCR2 10299 10514
PGAM1 10347 10422
HP 10242 10523
ATP6V0A1 10207 10551
LAMTOR1 10275 10468
FPR1 10352 10383

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201 6324
AAMP -546 -3061
ABCA13 9337 4245
ABI1 7076 8607
ABI2 -8604 -8517
ABL1 -8248 3812
ACAA1 7355 9532
ACLY -3480 8333
ACTB 10142 9915
ACTG1 8859 9583
ACTR10 9447 8995
ACTR1B -9174 -7104
ACTR2 9004 9240
ACTR3 9818 8294
ADAM10 9652 10284
ADAM8 1203 2391
ADGRE3 -6203 -8538
ADGRE5 -10156 -1430
ADGRG3 4594 7820
AGA -8931 1617
AGER 1815 2573
AGL -5887 971
AGPAT2 9571 10463
AHCYL1 4949 8470
AIM2 5049 -2546
ALAD 5688 9906
ALDH3B1 9122 10008
ALDOA 10140 10121
ALDOC 3900 -6356
ALOX5 9735 9772
ALPK1 10301 9030
AMPD3 8883 9878
ANO6 7295 8568
ANPEP 10206 10073
ANXA2 9791 10138
AOC1 4561 3551
AP1M1 392 8050
AP2A2 5529 9467
APAF1 9662 9512
APEH -6699 1881
APP 10085 9961
APRT 3186 -4197
ARG1 9516 8264
ARHGAP9 -4182 7692
ARL8A 9465 8775
ARMC8 9323 7367
ARPC1A 9171 9991
ARPC1B 9189 10351
ARPC2 7187 8262
ARPC3 9674 9506
ARPC4 7777 8635
ARPC5 9932 9762
ARSA 6282 1069
ARSB 8290 9046
ASAH1 9394 10144
ATAD3B -4315 -7816
ATF1 9088 8764
ATF2 8316 2303
ATG12 7501 4030
ATG5 8860 2955
ATG7 9954 8519
ATOX1 2131 5843
ATP11A 6284 9116
ATP11B -350 6286
ATP6AP2 9781 8803
ATP6V0A1 10207 10551
ATP6V0A2 -10746 -8412
ATP6V0B 9087 9653
ATP6V0C 9621 9869
ATP6V0D1 10069 10341
ATP6V0E1 8986 9188
ATP6V0E2 -4949 -10370
ATP6V1A 10093 10441
ATP6V1B2 10130 10122
ATP6V1C1 10266 9394
ATP6V1C2 -1408 -231
ATP6V1D 9919 9993
ATP6V1E1 9071 8178
ATP6V1E2 9253 5767
ATP6V1F 8059 6808
ATP6V1G1 7364 3710
ATP6V1G2 -3663 -8648
ATP6V1H 8628 8476
ATP7A -7540 3791
ATP8A1 -10266 -10371
ATP8B4 7565 8129
AZU1 9907 1592
B2M 58 -7420
B4GALT1 -3872 6820
BAIAP2 -5772 -4014
BCL10 6535 3786
BCL2 5399 -4548
BCL2L1 9471 8431
BIN2 -8436 8915
BIRC2 8116 2944
BIRC3 2030 -10298
BPI 9742 5505
BRI3 8728 10115
BRK1 5824 7761
BST1 10348 10335
BST2 -3420 -6690
BTK 5823 9633
BTRC -7062 1812
C1QA 2730 7449
C1QB 7676 9366
C1QC 8977 9784
C1R -9046 -4725
C1S -1133 4982
C2 9215 6100
C3 -10957 -10571
C3AR1 8008 9376
C4A 6469 1331
C4B 3894 -2194
C4BPB 2719 -2804
C5 6559 4756
C5AR1 9773 10201
C5AR2 8236 7910
C6orf120 5027 7382
C8G -10359 -8822
CAB39 9229 8388
CALM1 -4337 1051
CAMP 4319 -2875
CAND1 1355 -1576
CANT1 6929 6926
CAP1 9134 8626
CAPN1 5416 9742
CAPZA1 9332 9316
CAPZA2 10077 9039
CARD11 -10821 -9353
CARD9 6858 7100
CASP1 9611 2857
CASP10 2384 -199
CASP2 -6424 -1786
CASP4 8983 4399
CASP8 -9202 -9212
CASP9 4638 9486
CAT 9642 9941
CCR2 10299 10514
CCR6 -1173 -9034
CCT2 6166 -5938
CCT8 9483 8073
CD14 10063 10306
CD177 9884 10435
CD180 -1342 -678
CD19 -5755 -965
CD209 -2682 -9420
CD247 -10994 -10515
CD300A -7444 -2295
CD300E 8899 7631
CD300LB 7853 5455
CD33 9741 8810
CD36 10363 10493
CD3G -8283 -10568
CD4 1506 -6863
CD44 9109 9660
CD46 7723 3480
CD47 -8631 -9598
CD53 7763 9356
CD55 9747 10312
CD58 8027 7845
CD59 6386 4199
CD63 9814 10489
CD68 9480 10077
CD81 -10198 -7220
CD93 10231 10668
CDA 10040 10360
CDC34 7794 8739
CDC42 9246 8570
CDK13 -10473 -1209
CEACAM1 8525 8200
CEACAM3 5874 4896
CEACAM6 9295 4203
CEACAM8 9490 3624
CEP290 515 -6593
CFB 4527 1298
CFD 911 -342
CFH 4430 -8637
CFL1 9368 9341
CFP 8398 8912
CGAS 8887 6266
CHI3L1 6877 -4064
CHIT1 9419 6195
CHUK 9608 9191
CKAP4 10349 9973
CLEC10A -3689 -7601
CLEC12A 7370 3483
CLEC4A 9947 8689
CLEC4C -10672 -8976
CLEC4D 10190 9618
CLEC4E 8324 9161
CLEC5A 9868 9360
CLEC6A 6003 9020
CLEC7A 8710 5032
CLU 8797 10607
CMTM6 9160 8256
CNN2 4530 6242
CNPY3 7051 7961
COMMD3 3550 2189
COMMD9 9687 9081
COPB1 9548 8670
COTL1 8714 9141
CPN2 4742 5903
CPNE1 -7255 -6504
CPNE3 8631 6794
CPPED1 9095 9222
CR1 10309 10566
CR2 -1369 -1274
CRACR2A -10855 -4635
CRCP 1055 6373
CREB1 2938 -595
CREBBP -9358 1958
CREG1 10146 10578
CRISP3 5459 7621
CRISPLD2 9797 10342
CRK 9214 9663
CSNK2B 4787 4600
CST3 5014 -1198
CSTB 7160 8738
CTNNB1 1446 7186
CTSA 10310 10636
CTSB 9828 10631
CTSC -3910 5638
CTSD 9997 10635
CTSG 9668 2004
CTSH 9551 7551
CTSK 7599 3855
CTSL -5492 6157
CTSS 10120 8325
CTSV 3692 -1862
CTSZ 9796 10451
CUL1 7475 -10175
CXCL1 7627 4227
CXCR1 3353 4270
CXCR2 5266 1302
CYB5R3 7459 10015
CYBA 5409 8122
CYBB 10294 9839
CYFIP1 10019 10571
CYFIP2 -10388 -8406
CYLD 3384 -10382
CYSTM1 10132 9426
DBNL 4127 8290
DDOST 5768 8734
DDX3X 7864 5693
DDX41 278 3333
DDX58 -8090 -10356
DEFA1 9522 5409
DEFA3 8687 1751
DEFA4 9728 4397
DEGS1 8935 6383
DERA 9456 9825
DGAT1 879 2318
DHX36 2151 -303
DHX58 -8207 -10336
DHX9 2898 2519
DIAPH1 -9285 3050
DNAJC13 8999 9866
DNAJC3 9070 9215
DNAJC5 8864 9763
DNASE1L1 7707 10229
DNM1 5661 -1028
DNM2 -2349 6839
DNM3 1942 8165
DOCK1 2337 9856
DOCK2 3702 9336
DOK3 10044 10449
DPP7 -979 -5002
DSC1 3313 -7945
DSN1 -8664 -5515
DSP -4419 -1253
DTX4 -8103 7893
DUSP3 10238 10410
DUSP4 -3900 -8336
DUSP6 7156 -2241
DUSP7 -5905 -3113
DYNC1H1 -9811 -4718
DYNC1LI1 8227 7194
DYNLL1 6414 7208
DYNLT1 6878 3642
ECSIT 5443 4562
EEA1 6276 7915
EEF1A1 2936 -4796
EEF2 -3419 -1260
ELANE 10082 5779
ELK1 5371 2922
ELMO1 3674 6433
ELMO2 -6937 7218
ENPP4 -10352 -5923
EP300 -2315 7280
EPPIN 5366 4844
EPX 784 -848
ERP44 9756 6863
FABP5 6772 7102
FADD -3902 4370
FAF2 3745 8707
FBXW11 3233 8725
FCAR 10261 9489
FCER1A -10731 -10462
FCER1G 9338 9547
FCGR1A 10365 10249
FCGR2A 9647 9000
FCGR3A -11031 -7169
FCGR3B 5213 -2356
FCN1 10313 9522
FGL2 9767 -4215
FGR 7776 10127
FOLR3 8487 6843
FOS 7518 2641
FPR1 10352 10383
FPR2 10305 10056
FRK -3103 1427
FRMPD3 -10958 -9622
FTH1 1622 1016
FTL 9418 9788
FUCA1 9326 10044
FUCA2 9523 9365
FYN -10683 -7016
GAA 8463 8516
GAB2 6405 10289
GALNS 6891 7996
GCA 10340 10301
GDI2 8435 8742
GGH 7094 6779
GHDC 425 764
GLA 7742 9617
GLB1 9395 10125
GLIPR1 10116 7714
GM2A 9951 10624
GMFG 8707 8365
GNLY -10493 -10248
GNS 9753 10593
GOLGA7 5151 3331
GPI 3695 7384
GPR84 10189 9570
GRAP2 -2556 4557
GRB2 9960 10389
GRN 10105 10416
GSDMD 4103 -1714
GSN 10108 9436
GSTP1 2629 -1335
GUSB 3888 9979
GYG1 9967 10059
GZMM -10508 -10275
HBB 9671 6093
HCK 10073 9850
HEBP2 7929 9318
HERC5 -10330 -10561
HEXB 9686 9967
HGSNAT 2790 2412
HK3 10197 10277
HLA-A -3294 -7605
HLA-B 5549 -2345
HLA-C 1664 -2812
HLA-E -9947 -7245
HLA-H -8262 -1093
HMGB1 3409 1050
HMOX2 -9635 -10507
HP 10242 10523
HPSE 9308 10055
HRAS 2906 -3843
HRNR -8222 -7950
HSP90AA1 5650 1245
HSP90AB1 4616 -5342
HSP90B1 8375 1593
HSPA1A 8518 7125
HSPA1B 4687 5369
HSPA6 4663 3881
HSPA8 -4222 -8984
HTN1 -1472 -3845
HUWE1 -9990 -3993
HVCN1 5605 5771
ICAM2 -8278 -10459
ICAM3 5534 8302
IDH1 10341 10649
IFI16 8129 897
IFIH1 -104 -9711
IGF2R -5530 9230
IGHE -4940 -4979
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
IKBKB -6356 -1160
IKBKE 3422 7754
IKBKG -595 7203
IL1B 9843 323
ILF2 6408 2915
IMPDH1 10166 10137
IMPDH2 543 -9049
IQGAP1 6734 9841
IQGAP2 3533 9892
IRAK1 2858 6473
IRAK2 -10838 -5931
IRAK3 9582 10412
IRF3 -453 -6404
IRF7 -7026 -8410
ISG15 -9687 -10630
IST1 2776 6310
ITCH -3904 5799
ITGAL -10521 -8351
ITGAM 10114 10483
ITGAV 4141 7107
ITGAX 4703 8540
ITGB2 9132 10614
ITK -5396 -10354
ITLN1 -8675 -6281
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
JUN 481 -1015
JUP -10174 -7667
KCMF1 5611 7491
KCNAB2 -9357 6982
KIR2DS4 -10995 -5686
KLRC2 -9458 -9078
KLRD1 -10990 -9402
KLRK1 -10833 -10375
KPNB1 67 557
KRAS 4388 5328
KRT1 8174 5752
LAIR1 -2261 9900
LAMP1 1557 8684
LAMP2 9626 9234
LAMTOR1 10275 10468
LAMTOR2 6251 9811
LAMTOR3 9336 8131
LAT -8158 -10401
LAT2 8450 9858
LCK -9185 -10569
LCN2 9492 6870
LCP2 5338 -3004
LEAP2 701 -924
LGALS3 9840 9259
LGMN -2173 -1771
LILRB2 7666 10116
LILRB3 8925 10163
LIMK1 2972 6500
LPCAT1 -10615 -1283
LPO 5708 5822
LRG1 8829 9304
LRRC7 -2647 1172
LRRFIP1 7097 6307
LTA4H 10110 10291
LTF 9350 4940
LY86 9998 9324
LY96 9677 9581
LYN 8483 8583
LYZ 10158 5170
MAGT1 4037 5258
MALT1 -1899 -9188
MAN2B1 6033 6605
MANBA 8844 7868
MAP2K1 8861 10365
MAP2K3 8777 8502
MAP2K4 5525 7430
MAP2K6 8704 10103
MAP2K7 -1568 2972
MAP3K1 380 8292
MAP3K14 -10297 -9536
MAP3K7 2469 7237
MAP3K8 -7148 10028
MAPK1 -1086 9427
MAPK10 6946 6199
MAPK11 8895 6888
MAPK12 5297 -5399
MAPK13 -7306 -466
MAPK14 10026 9803
MAPK3 9769 9676
MAPK7 -9798 3379
MAPK8 -794 -7374
MAPK9 -6911 1519
MAPKAPK2 -10648 4888
MAPKAPK3 7908 10021
MASP2 836 -2977
MAVS 5118 9914
MCEMP1 10355 10554
MEF2A 8559 9073
MEF2C 5395 -197
MEFV 9121 9560
METTL7A 6476 8678
MGAM 9062 9613
MGST1 10318 10658
MIF -427 -5003
MLEC -220 4725
MME -3693 -8367
MMP25 7595 8922
MMP8 5024 9987
MMP9 8967 1371
MNDA 10302 9902
MOSPD2 10095 8658
MPO 10011 5205
MRE11 -103 -6016
MS4A2 -8308 -10092
MS4A3 8641 -1759
MUC1 9675 8255
MUC12 -9171 -8879
MUC16 -3838 -3439
MUC20 3464 -5169
MUC4 244 775
MUC5B -6905 -2911
MUC6 -1039 -983
MUCL1 -1284 2959
MVP 8914 6884
MYD88 8926 8524
MYH9 -3200 7267
MYO10 9262 10223
MYO1C 4706 3451
MYO5A 2173 8638
MYO9B -3670 7822
NAPRT 6733 8768
NBEAL2 4481 7538
NCF1 7986 3322
NCF2 10167 10265
NCF4 10090 10097
NCK1 -8084 -8497
NCKAP1 2316 10142
NCKAP1L 1901 10162
NCKIPSD 289 -2712
NCSTN 9915 10361
NDUFC2 7348 9008
NEU1 9609 10026
NF2 -9490 -6173
NFAM1 9877 10409
NFATC1 -9820 -3625
NFATC2 -10949 -10428
NFATC3 -10649 -10621
NFKB1 8527 5403
NFKB2 5450 -6553
NFKBIA 8114 5809
NFKBIB -5904 1139
NHLRC3 4425 7076
NIT2 -5470 -9344
NKIRAS1 1465 2281
NKIRAS2 9577 10434
NLRC3 -10795 -10430
NLRC4 10215 10499
NLRC5 -4707 -10102
NLRP1 -4418 -6987
NLRP3 9713 9646
NLRX1 1862 9184
NME2 5550 1269
NOD1 -10556 -9537
NOD2 9289 9320
NOS1 -86 528
NOS3 7751 -4608
NPC2 8648 6362
NRAS 8582 7708
OLFM4 4279 7865
OLR1 9142 -629
ORM1 9208 6694
ORM2 1731 -2088
ORMDL3 -10039 -8440
OSCAR 9873 9943
OSTF1 7593 8307
OTUD5 -6013 -4938
P2RX1 566 10417
P2RX7 7506 2020
PA2G4 5160 -928
PADI2 10200 10268
PAFAH1B2 7578 8153
PAK1 10129 7653
PAK2 9098 8874
PAK3 -1475 -334
PANX1 6838 8716
PCBP2 5133 2907
PDAP1 3713 8107
PDPK1 -54 8056
PDXK 9531 9355
PDZD11 -3651 -3584
PECAM1 7190 9387
PELI1 8918 5667
PELI2 7349 9515
PELI3 -320 9317
PFKL -4628 -3901
PGAM1 10347 10422
PGLYRP1 9124 7399
PGLYRP2 -8765 -3233
PGM1 2601 6092
PGM2 10212 10292
PGRMC1 6912 7496
PI3 8852 -5909
PIGR 3970 5820
PIK3C3 4588 3248
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3R1 -7314 -9108
PIK3R2 2369 6022
PIK3R4 -624 -83
PIN1 -6018 434
PKM 10317 10280
PLA2G6 -10438 -10350
PLAC8 8969 10175
PLAU 4112 3352
PLAUR 9724 9965
PLCG1 -5836 -10187
PLCG2 -6227 6708
PLD1 10119 10572
PLD2 6138 9091
PLD3 8046 6488
PLD4 -11002 -10493
PLEKHO2 6402 8506
PLPP5 -9164 -5630
PNP 9592 9563
POLR1C -936 -9350
POLR1D 8801 7295
POLR2E 8013 8218
POLR2F 320 5451
POLR2H 4812 -2703
POLR2K 7511 2990
POLR2L 2955 6234
POLR3A -7506 1498
POLR3B -3732 -354
POLR3C 1799 -1247
POLR3D -8901 -9448
POLR3E -9965 -8825
POLR3F 6952 -2664
POLR3G -7149 -4501
POLR3GL -7171 962
POLR3H -5579 -9356
POLR3K -1331 -2064
PPBP 5440 6001
PPIA 285 1417
PPIE -3976 -8580
PPP2CA 9766 8577
PPP2CB 9136 9093
PPP2R1A 1997 5379
PPP2R1B 3691 1706
PPP2R5D -5620 3209
PPP3CA 3489 7766
PPP3CB 9261 8237
PPP3R1 8749 9050
PRCP 9464 9217
PRDX4 7205 2372
PRDX6 9478 8747
PRKACA 9995 10558
PRKACB -8479 -10448
PRKCD 9710 9721
PRKCE -10688 -925
PRKCQ -9967 -10691
PRKCSH 1054 6027
PRKDC -9391 -8118
PROS1 8002 7705
PRTN3 10009 6834
PSAP 8066 8239
PSEN1 7406 9055
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
PSTPIP1 635 9877
PTAFR 10084 10562
PTGES2 -4699 -4573
PTK2 4992 3213
PTPN11 3471 9688
PTPN4 -10744 -10485
PTPN6 3230 7923
PTPRB -9309 -1901
PTPRC -4530 4553
PTPRJ 1010 9383
PTPRN2 7727 4489
PTX3 9712 4622
PYCARD 8846 9930
PYGB -6473 454
PYGL 10308 10199
QPCT 10273 10185
QSOX1 9888 10475
RAB10 9916 9959
RAB14 8765 8436
RAB18 9744 7495
RAB24 5628 2552
RAB27A 9159 9152
RAB31 10008 10290
RAB37 -10867 -10259
RAB3A 6440 9746
RAB3D 9091 10183
RAB44 6119 -1305
RAB4B -3971 4641
RAB5B -279 7773
RAB5C 8923 9415
RAB6A 8383 9332
RAB7A 9941 9609
RAB9B -6342 1453
RAC1 9345 9946
RAC2 -1305 4460
RAF1 8083 7846
RAP1A 9691 8186
RAP1B -3254 7324
RAP2B -7124 -440
RAP2C 785 5615
RASGRP1 -9188 -10645
RASGRP2 -6869 -9348
RASGRP4 10117 10286
RBSN -8580 -3332
RELA -2847 -1359
RELB 6278 918
RETN 10075 10034
RHOA 9541 9090
RHOF -10845 -10601
RHOG 8649 8946
RIPK1 -8110 -7415
RIPK2 8675 2009
RIPK3 -2562 6478
RNASE2 10359 10657
RNASE3 10043 8604
RNASE6 7700 7341
RNASET2 5772 5567
RNF125 -8051 -8470
RNF135 9310 10213
RNF216 -7199 -9744
ROCK1 5871 8890
RPS27A -1868 -5386
RPS6KA1 1245 8996
RPS6KA2 -5842 2331
RPS6KA3 1034 3942
RPS6KA5 70 -10393
S100A1 -2763 -3665
S100A11 10016 9498
S100A12 10367 10617
S100A8 10362 10564
S100A9 10316 10598
S100B -10129 814
S100P 8625 9159
SARM1 -9903 -10510
SCAMP1 6325 2268
SDCBP 10246 10113
SELL 9795 9352
SEM1 5210 6938
SERPINA1 10186 10295
SERPINB1 10330 10507
SERPINB10 10233 9723
SERPINB6 4741 9944
SERPING1 533 -10700
SHC1 3101 5292
SIGIRR -8187 -8512
SIGLEC14 9432 1567
SIGLEC15 9777 10043
SIGLEC16 10250 10302
SIGLEC5 9147 7119
SIGLEC9 9906 10513
SIKE1 5752 -1551
SIRPA 10351 10576
SIRPB1 7561 9956
SKP1 8911 4204
SLC11A1 9804 10582
SLC15A4 -7633 6832
SLC27A2 8033 -6002
SLC2A3 10169 9727
SLC2A5 7318 181
SLC44A2 -3421 2167
SLCO4C1 -9301 4048
SLPI 9574 1116
SNAP23 9581 8746
SNAP29 -5542 9818
SOCS1 8467 6659
SOS1 2394 -4661
SPTAN1 -10045 -9563
SRC -4936 -8846
SRP14 5097 7759
STAT6 195 7872
STBD1 6327 6394
STING1 8496 4759
STK10 -10751 -1875
STK11IP -4945 7132
STOM 2462 8162
SUGT1 4885 5013
SURF4 6833 7852
SVIP 3352 1164
SYK 9750 10350
SYNGR1 -5375 -4808
TAB1 7080 3716
TAB2 8556 6836
TAB3 215 4794
TANK 9785 8152
TARM1 9495 6302
TAX1BP1 7589 7124
TBC1D10C -10068 -10544
TBK1 8071 5122
TCIRG1 253 9871
TCN1 9143 3640
TEC 6790 9842
TICAM1 6577 5314
TICAM2 9445 5256
TIFA 8991 2402
TIMP2 10080 10603
TIRAP -8 6185
TKFC 6312 5992
TLR1 10059 9241
TLR10 -4242 -4361
TLR2 10239 9881
TLR3 -9392 -9897
TLR4 9286 10255
TLR5 9706 9984
TLR6 9187 9277
TLR7 9073 -6333
TLR8 10249 10439
TLR9 -10559 -4710
TMBIM1 8125 9006
TMC6 -6434 -9567
TMEM179B 5717 -1815
TMEM30A 9426 8525
TMEM63A -1855 -9668
TNFAIP3 -10143 -6698
TNFAIP6 9826 9521
TNFRSF1B -1892 8266
TNIP2 -929 4907
TOLLIP 8936 8482
TOM1 9316 10512
TRAF2 -7822 -10338
TRAF3 3014 -4910
TRAF6 -4471 1582
TRAPPC1 6932 9117
TREM1 7594 8932
TREX1 4501 -2650
TRIM21 7812 -1089
TRIM25 9125 8899
TRIM32 -9103 -9631
TRIM56 -6855 -7154
TRPM2 9977 10050
TSPAN14 -3505 8543
TUBB -6747 -3278
TUBB4B 7592 5692
TXK -9126 -9892
TXN 9660 8103
TXNDC5 5836 -3635
TXNIP -7875 -4331
TYROBP 6739 8642
UBA3 10160 9196
UBA52 2067 260
UBA7 -3644 -6517
UBB 7788 3835
UBC 2562 2822
UBE2D1 10262 10093
UBE2D2 5413 5174
UBE2D3 9631 8934
UBE2K 9809 8979
UBE2L6 -3435 -10632
UBE2M 3363 8550
UBE2N 7813 4195
UBE2V1 8249 8108
UBR4 -9246 -21
UNC13D -69 8894
UNC93B1 42 5485
VAMP8 7797 7239
VAPA 9859 9626
VAT1 9646 10524
VAV1 6299 7892
VAV2 -9043 2054
VAV3 -7486 7780
VCL 913 8321
VCP 7591 6702
VNN1 10163 10414
VPS35L 6316 8792
VRK3 -2450 3426
VTN 714 1913
WAS 9521 9854
WASF1 10267 10673
WASF2 6329 9933
WASF3 5357 6353
WASL -3272 1473
WIPF1 -7238 -2901
WIPF2 1332 7562
XRCC5 7806 6087
XRCC6 6022 -236
YES1 -10892 -9337
YPEL5 5177 5140
ZBP1 -10466 -10697



Immune System

Immune System
metric value
setSize 1885
pMANOVA 3.55e-42
p.adjustMANOVA 1.61e-39
s.dist 0.241
s.low.CRP 0.182
s.high.CRP 0.158
p.low.CRP 3.38e-39
p.high.CRP 8.29e-30




Top 20 genes
Gene low CRP high CRP
CSF2RA 10368 10661
RNASE2 10359 10657
IDH1 10341 10649
S100A12 10367 10617
MGST1 10318 10658
SOCS3 10312 10656
CTSA 10310 10636
WASF1 10267 10673
SIRPA 10351 10576
S100A8 10362 10564
S100A9 10316 10598
MCEMP1 10355 10554
CD93 10231 10668
CR1 10309 10566
VAMP7 10303 10569
CD36 10363 10493
SERPINB1 10330 10507
SERPINB2 10291 10534
CCR2 10299 10514
PGAM1 10347 10422

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201.0 6324.0
AAAS -4220.0 -2848.0
AAMP -546.0 -3061.0
ABCA13 9337.0 4245.0
ABCE1 6075.0 -9621.0
ABHD17A -10062.0 -8554.0
ABHD17B -1683.0 1264.0
ABHD17C -6145.0 -1185.0
ABI1 7076.0 8607.0
ABI2 -8604.0 -8517.0
ABL1 -8248.0 3812.0
ACAA1 7355.0 9532.0
ACLY -3480.0 8333.0
ACTB 10142.0 9915.0
ACTG1 8859.0 9583.0
ACTR10 9447.0 8995.0
ACTR1A 1291.0 7735.0
ACTR1B -9174.0 -7104.0
ACTR2 9004.0 9240.0
ACTR3 9818.0 8294.0
ADAM10 9652.0 10284.0
ADAM17 4487.0 10398.0
ADAM8 1203.0 2391.0
ADAR -6808.0 -4937.0
ADGRE3 -6203.0 -8538.0
ADGRE5 -10156.0 -1430.0
ADGRG3 4594.0 7820.0
AGA -8931.0 1617.0
AGER 1815.0 2573.0
AGL -5887.0 971.0
AGPAT2 9571.0 10463.0
AHCYL1 4949.0 8470.0
AIM2 5049.0 -2546.0
AIP -7421.0 -3297.0
AKT1 -5096.0 2421.0
AKT2 -7693.0 3004.0
AKT3 -8346.0 -9755.0
ALAD 5688.0 9906.0
ALDH3B1 9122.0 10008.0
ALDOA 10140.0 10121.0
ALDOC 3900.0 -6356.0
ALOX15 -5374.0 -9427.0
ALOX5 9735.0 9772.0
ALPK1 10301.0 9030.0
AMPD3 8883.0 9878.0
ANAPC1 -9296.0 -9659.0
ANAPC10 -527.0 1902.0
ANAPC11 5022.0 6085.0
ANAPC13 8643.0 4530.0
ANAPC2 -5345.0 -6689.0
ANAPC4 2261.0 -3709.0
ANAPC5 -8128.0 -6414.0
ANAPC7 3531.0 1520.0
ANGPT1 -2624.0 1229.0
ANO6 7295.0 8568.0
ANPEP 10206.0 10073.0
ANXA1 8538.0 8818.0
ANXA2 9791.0 10138.0
AOC1 4561.0 3551.0
AP1B1 7607.0 10260.0
AP1G1 -1729.0 6706.0
AP1M1 392.0 8050.0
AP1M2 1215.0 549.0
AP1S1 10021.0 10574.0
AP1S2 7206.0 -5666.0
AP1S3 -7437.0 3269.0
AP2A1 -5326.0 9611.0
AP2A2 5529.0 9467.0
AP2B1 -8369.0 3155.0
AP2M1 7928.0 9269.0
AP2S1 8593.0 9630.0
APAF1 9662.0 9512.0
APBB1IP 10051.0 8873.0
APEH -6699.0 1881.0
APP 10085.0 9961.0
APRT 3186.0 -4197.0
ARAF 939.0 2823.0
AREG -5505.0 9162.0
AREL1 -3935.0 7981.0
ARF1 9085.0 10196.0
ARG1 9516.0 8264.0
ARHGAP9 -4182.0 7692.0
ARIH1 -1485.0 3433.0
ARIH2 -10264.0 -8560.0
ARL2 3396.0 3132.0
ARL8A 9465.0 8775.0
ARMC8 9323.0 7367.0
ARPC1A 9171.0 9991.0
ARPC1B 9189.0 10351.0
ARPC2 7187.0 8262.0
ARPC3 9674.0 9506.0
ARPC4 7777.0 8635.0
ARPC5 9932.0 9762.0
ARRB1 -5720.0 3058.0
ARRB2 8232.0 9058.0
ARSA 6282.0 1069.0
ARSB 8290.0 9046.0
ASAH1 9394.0 10144.0
ASB1 -7836.0 6220.0
ASB13 1661.0 1645.0
ASB14 762.0 662.0
ASB16 -4955.0 -2085.0
ASB2 -10383.0 -9299.0
ASB3 5783.0 4906.0
ASB4 -5402.0 -5291.0
ASB6 -7850.0 -4746.0
ASB7 5499.0 6321.0
ASB8 2931.0 5919.0
ASB9 1599.0 714.0
ATAD3B -4315.0 -7816.0
ATF1 9088.0 8764.0
ATF2 8316.0 2303.0
ATG12 7501.0 4030.0
ATG5 8860.0 2955.0
ATG7 9954.0 8519.0
ATOX1 2131.0 5843.0
ATP11A 6284.0 9116.0
ATP11B -350.0 6286.0
ATP6AP2 9781.0 8803.0
ATP6V0A1 10207.0 10551.0
ATP6V0A2 -10746.0 -8412.0
ATP6V0B 9087.0 9653.0
ATP6V0C 9621.0 9869.0
ATP6V0D1 10069.0 10341.0
ATP6V0E1 8986.0 9188.0
ATP6V0E2 -4949.0 -10370.0
ATP6V1A 10093.0 10441.0
ATP6V1B2 10130.0 10122.0
ATP6V1C1 10266.0 9394.0
ATP6V1C2 -1408.0 -231.0
ATP6V1D 9919.0 9993.0
ATP6V1E1 9071.0 8178.0
ATP6V1E2 9253.0 5767.0
ATP6V1F 8059.0 6808.0
ATP6V1G1 7364.0 3710.0
ATP6V1G2 -3663.0 -8648.0
ATP6V1H 8628.0 8476.0
ATP7A -7540.0 3791.0
ATP8A1 -10266.0 -10371.0
ATP8B4 7565.0 8129.0
AZU1 9907.0 1592.0
B2M 58.0 -7420.0
B4GALT1 -3872.0 6820.0
BAIAP2 -5772.0 -4014.0
BATF 7739.0 7840.0
BCL10 6535.0 3786.0
BCL2 5399.0 -4548.0
BCL2L1 9471.0 8431.0
BCL6 10173.0 10019.0
BIN2 -8436.0 8915.0
BIRC2 8116.0 2944.0
BIRC3 2030.0 -10298.0
BIRC5 5078.0 5144.0
BLK -6450.0 -461.0
BLMH 5574.0 3091.0
BLNK -7737.0 -4051.0
BOLA2 3751.0 -209.0
BPI 9742.0 5505.0
BRAF -5814.0 3049.0
BRAP 6562.0 6795.0
BRI3 8728.0 10115.0
BRK1 5824.0 7761.0
BRWD1 -7651.0 -7506.0
BST1 10348.0 10335.0
BST2 -3420.0 -6690.0
BTBD1 6779.0 3894.0
BTBD6 -7180.0 -3405.0
BTK 5823.0 9633.0
BTLA -7521.0 -1610.0
BTN1A1 2732.0 1123.0
BTN2A1 -3656.0 -9795.0
BTN2A2 -9255.0 -9874.0
BTN3A1 -10822.0 -10591.0
BTN3A2 -8177.0 -9590.0
BTN3A3 -10661.0 -10532.0
BTNL8 2314.0 5341.0
BTNL9 2765.0 -642.0
BTRC -7062.0 1812.0
C1QA 2730.0 7449.0
C1QB 7676.0 9366.0
C1QC 8977.0 9784.0
C1R -9046.0 -4725.0
C1S -1133.0 4982.0
C2 9215.0 6100.0
C3 -10957.0 -10571.0
C3AR1 8008.0 9376.0
C4A 6469.0 1331.0
C4B 3894.0 -2194.0
C4BPB 2719.0 -2804.0
C5 6559.0 4756.0
C5AR1 9773.0 10201.0
C5AR2 8236.0 7910.0
C6orf120 5027.0 7382.0
C8G -10359.0 -8822.0
CA1 10237.0 10011.0
CAB39 9229.0 8388.0
CALM1 -4337.0 1051.0
CALR 8310.0 6954.0
CAMK2D -5436.0 -9961.0
CAMK2G 3580.0 -6522.0
CAMP 4319.0 -2875.0
CAND1 1355.0 -1576.0
CANT1 6929.0 6926.0
CANX 7507.0 7257.0
CAP1 9134.0 8626.0
CAPN1 5416.0 9742.0
CAPZA1 9332.0 9316.0
CAPZA2 10077.0 9039.0
CAPZB 8393.0 8843.0
CARD11 -10821.0 -9353.0
CARD9 6858.0 7100.0
CASP1 9611.0 2857.0
CASP10 2384.0 -199.0
CASP2 -6424.0 -1786.0
CASP3 4165.0 2978.0
CASP4 8983.0 4399.0
CASP8 -9202.0 -9212.0
CASP9 4638.0 9486.0
CAT 9642.0 9941.0
CBL 1852.0 8579.0
CBLB -10836.0 -9896.0
CCL2 -10551.0 -10635.0
CCL3 -1192.0 -5558.0
CCL4 -10973.0 -8565.0
CCL5 -10431.0 -10290.0
CCND1 -3107.0 -2342.0
CCNF -9341.0 -8844.0
CCR1 10287.0 9826.0
CCR2 10299.0 10514.0
CCR5 -9310.0 -7370.0
CCR6 -1173.0 -9034.0
CCT2 6166.0 -5938.0
CCT8 9483.0 8073.0
CD101 8455.0 544.0
CD14 10063.0 10306.0
CD160 -10745.0 -8985.0
CD177 9884.0 10435.0
CD180 -1342.0 -678.0
CD19 -5755.0 -965.0
CD1A -2232.0 -4250.0
CD1C -10461.0 -10603.0
CD1D 8654.0 8993.0
CD200 -3407.0 -396.0
CD200R1 3188.0 -10005.0
CD209 -2682.0 -9420.0
CD22 -4690.0 -6104.0
CD226 -8589.0 -7857.0
CD247 -10994.0 -10515.0
CD27 -25.0 -8750.0
CD274 7804.0 -10162.0
CD28 -328.0 -10542.0
CD300A -7444.0 -2295.0
CD300C 10074.0 10304.0
CD300E 8899.0 7631.0
CD300LB 7853.0 5455.0
CD300LD 8274.0 4518.0
CD300LF 8429.0 6409.0
CD33 9741.0 8810.0
CD34 -1977.0 -8516.0
CD36 10363.0 10493.0
CD3D -7327.0 -10481.0
CD3E -4636.0 -10489.0
CD3G -8283.0 -10568.0
CD4 1506.0 -6863.0
CD40 -2209.0 -5946.0
CD40LG -1104.0 -9898.0
CD44 9109.0 9660.0
CD46 7723.0 3480.0
CD47 -8631.0 -9598.0
CD53 7763.0 9356.0
CD55 9747.0 10312.0
CD58 8027.0 7845.0
CD59 6386.0 4199.0
CD63 9814.0 10489.0
CD68 9480.0 10077.0
CD70 2259.0 -2934.0
CD74 -7667.0 -10115.0
CD79A -6293.0 -3766.0
CD79B -8417.0 -6298.0
CD80 -7610.0 -7443.0
CD81 -10198.0 -7220.0
CD86 6726.0 -1548.0
CD8A -6577.0 -9947.0
CD8B 2861.0 -10223.0
CD93 10231.0 10668.0
CD96 -9204.0 -10663.0
CD99 4318.0 9773.0
CDA 10040.0 10360.0
CDC16 -4738.0 -1477.0
CDC20 3581.0 3590.0
CDC23 -5476.0 -5775.0
CDC26 7265.0 4357.0
CDC27 4432.0 3370.0
CDC34 7794.0 8739.0
CDC42 9246.0 8570.0
CDH1 -10326.0 -6171.0
CDK13 -10473.0 -1209.0
CDKN1A -1680.0 4429.0
CEACAM1 8525.0 8200.0
CEACAM3 5874.0 4896.0
CEACAM6 9295.0 4203.0
CEACAM8 9490.0 3624.0
CEBPD 8189.0 10136.0
CENPE -3770.0 492.0
CEP290 515.0 -6593.0
CFB 4527.0 1298.0
CFD 911.0 -342.0
CFH 4430.0 -8637.0
CFL1 9368.0 9341.0
CFP 8398.0 8912.0
CGAS 8887.0 6266.0
CHI3L1 6877.0 -4064.0
CHIT1 9419.0 6195.0
CHUK 9608.0 9191.0
CIITA -5259.0 -8494.0
CISH 9949.0 -655.0
CKAP4 10349.0 9973.0
CLCF1 -9992.0 -10173.0
CLEC10A -3689.0 -7601.0
CLEC12A 7370.0 3483.0
CLEC2B -2778.0 -8559.0
CLEC2D -10552.0 -10550.0
CLEC4A 9947.0 8689.0
CLEC4C -10672.0 -8976.0
CLEC4D 10190.0 9618.0
CLEC4E 8324.0 9161.0
CLEC4G 4981.0 9160.0
CLEC5A 9868.0 9360.0
CLEC6A 6003.0 9020.0
CLEC7A 8710.0 5032.0
CLTA 9206.0 9264.0
CLTC 9482.0 10359.0
CLU 8797.0 10607.0
CMTM6 9160.0 8256.0
CNKSR1 3442.0 -9142.0
CNKSR2 1572.0 -137.0
CNN2 4530.0 6242.0
CNPY3 7051.0 7961.0
CNTF 4718.0 7198.0
COL1A2 4726.0 5641.0
COLEC12 -10027.0 2954.0
COMMD3 3550.0 2189.0
COMMD9 9687.0 9081.0
COPB1 9548.0 8670.0
COTL1 8714.0 9141.0
CPN2 4742.0 5903.0
CPNE1 -7255.0 -6504.0
CPNE3 8631.0 6794.0
CPPED1 9095.0 9222.0
CR1 10309.0 10566.0
CR2 -1369.0 -1274.0
CRACR2A -10855.0 -4635.0
CRCP 1055.0 6373.0
CREB1 2938.0 -595.0
CREBBP -9358.0 1958.0
CREG1 10146.0 10578.0
CRISP3 5459.0 7621.0
CRISPLD2 9797.0 10342.0
CRK 9214.0 9663.0
CRKL -1879.0 4224.0
CRLF1 2635.0 -6307.0
CRTAM -10153.0 -9122.0
CSF1 3930.0 -7629.0
CSF1R -7879.0 1273.0
CSF2RA 10368.0 10661.0
CSF2RB 9224.0 5475.0
CSF3R 9933.0 8675.0
CSK -2015.0 6501.0
CSNK2B 4787.0 4600.0
CST3 5014.0 -1198.0
CSTB 7160.0 8738.0
CTF1 -3336.0 6154.0
CTLA4 -6563.0 -8789.0
CTNNB1 1446.0 7186.0
CTSA 10310.0 10636.0
CTSB 9828.0 10631.0
CTSC -3910.0 5638.0
CTSD 9997.0 10635.0
CTSF -10222.0 -9829.0
CTSG 9668.0 2004.0
CTSH 9551.0 7551.0
CTSK 7599.0 3855.0
CTSL -5492.0 6157.0
CTSO 3453.0 -7463.0
CTSS 10120.0 8325.0
CTSV 3692.0 -1862.0
CTSZ 9796.0 10451.0
CUL1 7475.0 -10175.0
CUL2 9537.0 5772.0
CUL3 7012.0 8018.0
CUL5 8446.0 4656.0
CUL7 -7732.0 2154.0
CXCL1 7627.0 4227.0
CXCL10 7706.0 -10646.0
CXCL2 2912.0 3723.0
CXCL8 5888.0 -3003.0
CXCR1 3353.0 4270.0
CXCR2 5266.0 1302.0
CYB5R3 7459.0 10015.0
CYBA 5409.0 8122.0
CYBB 10294.0 9839.0
CYFIP1 10019.0 10571.0
CYFIP2 -10388.0 -8406.0
CYLD 3384.0 -10382.0
CYSTM1 10132.0 9426.0
DAB2IP -8908.0 -5773.0
DAPP1 9506.0 2775.0
DBNL 4127.0 8290.0
DCTN1 -4701.0 7431.0
DCTN2 9097.0 10370.0
DCTN3 3675.0 7530.0
DCTN4 5909.0 10148.0
DCTN5 -6881.0 5731.0
DCTN6 9751.0 9405.0
DDOST 5768.0 8734.0
DDX3X 7864.0 5693.0
DDX41 278.0 3333.0
DDX58 -8090.0 -10356.0
DEFA1 9522.0 5409.0
DEFA3 8687.0 1751.0
DEFA4 9728.0 4397.0
DEGS1 8935.0 6383.0
DERA 9456.0 9825.0
DET1 6013.0 -7618.0
DGAT1 879.0 2318.0
DHX36 2151.0 -303.0
DHX58 -8207.0 -10336.0
DHX9 2898.0 2519.0
DIAPH1 -9285.0 3050.0
DLG1 -1129.0 -3343.0
DLG2 -5967.0 41.0
DLG3 -9607.0 -10641.0
DLG4 9782.0 9451.0
DNAJC13 8999.0 9866.0
DNAJC3 9070.0 9215.0
DNAJC5 8864.0 9763.0
DNASE1L1 7707.0 10229.0
DNM1 5661.0 -1028.0
DNM2 -2349.0 6839.0
DNM3 1942.0 8165.0
DOCK1 2337.0 9856.0
DOCK2 3702.0 9336.0
DOK3 10044.0 10449.0
DPP7 -979.0 -5002.0
DSC1 3313.0 -7945.0
DSN1 -8664.0 -5515.0
DSP -4419.0 -1253.0
DTX3L 5230.0 -5628.0
DTX4 -8103.0 7893.0
DUSP1 5484.0 7971.0
DUSP10 -1562.0 1761.0
DUSP16 -4653.0 -6088.0
DUSP2 -10154.0 -5293.0
DUSP3 10238.0 10410.0
DUSP4 -3900.0 -8336.0
DUSP5 -10770.0 -10188.0
DUSP6 7156.0 -2241.0
DUSP7 -5905.0 -3113.0
DUSP8 -9809.0 -10041.0
DYNC1H1 -9811.0 -4718.0
DYNC1I1 378.0 6338.0
DYNC1I2 8978.0 9397.0
DYNC1LI1 8227.0 7194.0
DYNC1LI2 909.0 7271.0
DYNLL1 6414.0 7208.0
DYNLL2 -5827.0 -2261.0
DYNLT1 6878.0 3642.0
DZIP3 -5270.0 -9440.0
EBI3 -8326.0 8419.0
ECSIT 5443.0 4562.0
EDA 8903.0 -3204.0
EDA2R 8666.0 -6826.0
EDAR -2069.0 -7937.0
EDARADD -7631.0 -10101.0
EEA1 6276.0 7915.0
EEF1A1 2936.0 -4796.0
EEF2 -3419.0 -1260.0
EGF 8136.0 8196.0
EGR1 7178.0 6141.0
EIF2AK2 -9087.0 -7734.0
EIF4A1 9825.0 8652.0
EIF4A2 -4531.0 -9693.0
EIF4A3 8711.0 7414.0
EIF4E 8016.0 7576.0
EIF4E2 8439.0 7930.0
EIF4E3 10056.0 7803.0
EIF4G1 5724.0 10120.0
EIF4G2 5753.0 7349.0
EIF4G3 5819.0 10415.0
ELANE 10082.0 5779.0
ELK1 5371.0 2922.0
ELMO1 3674.0 6433.0
ELMO2 -6937.0 7218.0
ELOB 7369.0 8033.0
ELOC 7870.0 9351.0
ENAH -6459.0 1871.0
ENPP4 -10352.0 -5923.0
EP300 -2315.0 7280.0
EPPIN 5366.0 4844.0
EPX 784.0 -848.0
ERAP1 -586.0 -4233.0
ERAP2 -3794.0 -2057.0
ERBB2 -11003.0 -9975.0
ERBB3 -597.0 1233.0
EREG -2190.0 5005.0
ERP44 9756.0 6863.0
EVL -9748.0 -10471.0
F13A1 9500.0 8453.0
FABP5 6772.0 7102.0
FADD -3902.0 4370.0
FAF2 3745.0 8707.0
FASLG -10999.0 -10620.0
FBXL12 -1698.0 -3377.0
FBXL13 -1382.0 3518.0
FBXL14 -8163.0 -6300.0
FBXL15 3436.0 2720.0
FBXL16 5507.0 -10081.0
FBXL18 -5099.0 5653.0
FBXL19 5732.0 10057.0
FBXL20 1765.0 3859.0
FBXL22 -9153.0 -6742.0
FBXL3 1966.0 670.0
FBXL4 4486.0 8310.0
FBXL5 10325.0 10075.0
FBXL8 7525.0 1281.0
FBXO10 -9379.0 306.0
FBXO11 7621.0 8299.0
FBXO15 230.0 1947.0
FBXO17 5781.0 1662.0
FBXO2 -9215.0 -4852.0
FBXO21 -8838.0 -6075.0
FBXO22 4944.0 -234.0
FBXO27 -8323.0 -1437.0
FBXO30 2042.0 4025.0
FBXO31 -10125.0 -10514.0
FBXO32 -9370.0 -9624.0
FBXO4 -4427.0 -9673.0
FBXO40 -1666.0 3411.0
FBXO41 -7713.0 3597.0
FBXO44 -2312.0 -7442.0
FBXO6 685.0 -1568.0
FBXO7 9204.0 6315.0
FBXO9 10306.0 10429.0
FBXW11 3233.0 8725.0
FBXW12 -8674.0 -7228.0
FBXW2 -2414.0 9274.0
FBXW4 -8829.0 -9797.0
FBXW5 -8630.0 250.0
FBXW7 -8232.0 -6782.0
FBXW8 -9913.0 -6070.0
FBXW9 -8279.0 -4295.0
FCAR 10261.0 9489.0
FCER1A -10731.0 -10462.0
FCER1G 9338.0 9547.0
FCER2 -3881.0 -3466.0
FCGR1A 10365.0 10249.0
FCGR1B 10361.0 9771.0
FCGR2A 9647.0 9000.0
FCGR2B -5892.0 1291.0
FCGR3A -11031.0 -7169.0
FCGR3B 5213.0 -2356.0
FCN1 10313.0 9522.0
FGF2 8825.0 5391.0
FGF22 -4199.0 -8205.0
FGF23 1297.0 -7622.0
FGF7 -1811.0 -5146.0
FGF9 -7810.0 -8061.0
FGFR1 -9793.0 -95.0
FGFR2 -10432.0 -10034.0
FGFR4 -1488.0 -4510.0
FGL2 9767.0 -4215.0
FGR 7776.0 10127.0
FKBP1A 10270.0 9273.0
FLNA -8851.0 2557.0
FLNB -10233.0 4955.0
FLT3 -1564.0 9968.0
FLT3LG 4903.0 -10389.0
FN1 9912.0 6648.0
FNTA 3450.0 -3347.0
FNTB 8850.0 5246.0
FOLR3 8487.0 6843.0
FOS 7518.0 2641.0
FOXO1 -8890.0 -9341.0
FOXO3 2533.0 10065.0
FPR1 10352.0 10383.0
FPR2 10305.0 10056.0
FRK -3103.0 1427.0
FRMPD3 -10958.0 -9622.0
FRS2 52.0 35.0
FRS3 9115.0 9931.0
FSCN1 8944.0 8203.0
FTH1 1622.0 1016.0
FTL 9418.0 9788.0
FUCA1 9326.0 10044.0
FUCA2 9523.0 9365.0
FYN -10683.0 -7016.0
FZR1 -6086.0 -3255.0
GAA 8463.0 8516.0
GAB1 3626.0 8241.0
GAB2 6405.0 10289.0
GALNS 6891.0 7996.0
GAN -7017.0 -911.0
GATA3 -8401.0 -10666.0
GBP1 815.0 -10685.0
GBP2 5731.0 -10602.0
GBP3 1571.0 -9103.0
GBP4 -6867.0 -10711.0
GBP5 -5156.0 -10722.0
GBP6 -3712.0 1212.0
GCA 10340.0 10301.0
GDI2 8435.0 8742.0
GFRA2 -10227.0 -4534.0
GGH 7094.0 6779.0
GHDC 425.0 764.0
GHR 2377.0 -3453.0
GLA 7742.0 9617.0
GLB1 9395.0 10125.0
GLIPR1 10116.0 7714.0
GLMN 2478.0 -9318.0
GM2A 9951.0 10624.0
GMFG 8707.0 8365.0
GNLY -10493.0 -10248.0
GNS 9753.0 10593.0
GOLGA7 5151.0 3331.0
GPI 3695.0 7384.0
GPR84 10189.0 9570.0
GRAP2 -2556.0 4557.0
GRB2 9960.0 10389.0
GRIN2D 6165.0 8087.0
GRN 10105.0 10416.0
GSDMD 4103.0 -1714.0
GSN 10108.0 9436.0
GSTO1 9989.0 10215.0
GSTP1 2629.0 -1335.0
GUSB 3888.0 9979.0
GYG1 9967.0 10059.0
GZMM -10508.0 -10275.0
H3C15 182.5 4598.5
HACE1 -7630.0 -1515.0
HAVCR2 -3410.0 9527.0
HBB 9671.0 6093.0
HBEGF -922.0 4467.0
HCK 10073.0 9850.0
HCST -7480.0 -4263.0
HEBP2 7929.0 9318.0
HECTD1 -6307.0 4259.0
HECTD2 -9862.0 -415.0
HECTD3 -5978.0 4640.0
HECW2 -6430.0 3846.0
HERC1 -10183.0 -6680.0
HERC2 -10819.0 -7035.0
HERC3 -2375.0 -865.0
HERC4 8486.0 6082.0
HERC5 -10330.0 -10561.0
HERC6 -10610.0 -10137.0
HEXB 9686.0 9967.0
HGF 8952.0 9949.0
HGSNAT 2790.0 2412.0
HIF1A 7766.0 8740.0
HK3 10197.0 10277.0
HLA-A -3294.0 -7605.0
HLA-B 5549.0 -2345.0
HLA-C 1664.0 -2812.0
HLA-DMA -3284.0 -9118.0
HLA-DMB -3514.0 -8778.0
HLA-DOA -10224.0 -10556.0
HLA-DOB 106.0 -4389.0
HLA-DPA1 -10572.0 -10652.0
HLA-DPB1 -10605.0 -10638.0
HLA-DQA1 -5841.0 -10469.0
HLA-DQA2 -4322.0 -3258.0
HLA-DQB1 2746.0 -7642.0
HLA-DQB2 -7036.0 -9597.0
HLA-DRA -8799.0 -10557.0
HLA-DRB1 -3832.0 -8988.0
HLA-DRB5 -5253.0 -8129.0
HLA-E -9947.0 -7245.0
HLA-F -9975.0 -10619.0
HLA-G -5725.0 -913.0
HLA-H -8262.0 -1093.0
HMGB1 3409.0 1050.0
HMOX1 6215.0 10321.0
HMOX2 -9635.0 -10507.0
HNRNPA2B1 4667.0 7450.0
HNRNPDL -6946.0 -8564.0
HNRNPF 5903.0 5564.0
HP 10242.0 10523.0
HPSE 9308.0 10055.0
HRAS 2906.0 -3843.0
HRNR -8222.0 -7950.0
HSP90AA1 5650.0 1245.0
HSP90AB1 4616.0 -5342.0
HSP90B1 8375.0 1593.0
HSPA1A 8518.0 7125.0
HSPA1B 4687.0 5369.0
HSPA5 9415.0 6475.0
HSPA6 4663.0 3881.0
HSPA8 -4222.0 -8984.0
HSPA9 -1007.0 -4614.0
HTN1 -1472.0 -3845.0
HUWE1 -9990.0 -3993.0
HVCN1 5605.0 5771.0
ICAM1 10112.0 3884.0
ICAM2 -8278.0 -10459.0
ICAM3 5534.0 8302.0
ICAM4 -5350.0 3056.0
ICAM5 2868.0 9830.0
ICMT -3482.0 2649.0
ICOS 2053.0 -9847.0
ICOSLG -5559.0 -8707.0
IDH1 10341.0 10649.0
IFI16 8129.0 897.0
IFI27 1253.0 -252.0
IFI30 9083.0 8903.0
IFI35 2136.0 -6181.0
IFI6 -10603.0 -10404.0
IFIH1 -104.0 -9711.0
IFIT1 -10782.0 -10589.0
IFIT2 -10121.0 -10667.0
IFIT3 -9557.0 -10535.0
IFIT5 -5527.0 -9997.0
IFITM1 -2007.0 -8054.0
IFITM2 -1993.0 6771.0
IFITM3 1855.0 -1800.0
IFNAR1 9540.0 8356.0
IFNAR2 5852.0 8082.0
IFNG -4670.0 -9064.0
IFNGR1 10033.0 10368.0
IFNGR2 10106.0 10294.0
IFNLR1 -9277.0 -6455.0
IGF2R -5530.0 9230.0
IGHD -3784.0 -6091.0
IGHE -4940.0 -4979.0
IGHG1 -3727.0 -9610.0
IGHG2 -2988.0 -6697.0
IGHG3 3688.0 -4504.0
IGHG4 -6480.0 -3573.0
IGHM -323.0 -1745.0
IGHV1-2 7949.0 -2404.0
IGHV1-46 1645.0 -7097.0
IGHV1-69 -473.0 -3585.0
IGHV2-5 -761.0 -7784.0
IGHV2-70 -5110.0 -2783.0
IGHV3-11 6603.0 -6880.0
IGHV3-13 -4367.0 -5652.0
IGHV3-23 5184.0 -7276.0
IGHV3-30 6205.0 -8897.0
IGHV3-33 -1859.0 -6548.0
IGHV3-48 1158.0 -4630.0
IGHV3-53 439.0 -4325.0
IGHV3-7 2687.0 -5396.0
IGHV4-34 -3831.0 -5446.0
IGHV4-39 -3715.0 -8660.0
IGHV4-59 1427.0 -4638.0
IGKC 3871.0 -8235.0
IGKV1-12 4565.0 -9660.0
IGKV1-16 4776.0 -5235.0
IGKV1-17 5659.0 -4913.0
IGKV1-33 5570.0 -6751.0
IGKV1-5 5340.0 -9482.0
IGKV1D-39 2361.0 -3975.0
IGKV2-28 600.0 -6240.0
IGKV2-30 2124.0 -5952.0
IGKV2D-28 -8241.0 -7171.0
IGKV3-11 4335.0 -8929.0
IGKV3-15 3182.0 -9110.0
IGKV3-20 3477.0 -8253.0
IGKV3D-20 -604.0 -487.0
IGKV4-1 5759.0 -5700.0
IGKV5-2 3670.0 -6960.0
IGLC1 -2564.0 -7780.0
IGLC2 -3391.0 -9023.0
IGLC3 -211.0 -3454.0
IGLC7 -5718.0 -8734.0
IGLV1-36 -1581.0 -5381.0
IGLV1-40 -5815.0 -8593.0
IGLV1-44 3169.0 -7580.0
IGLV1-47 -657.0 -7558.0
IGLV1-51 -1719.0 -7074.0
IGLV10-54 3553.0 -6006.0
IGLV2-11 1826.0 -4201.0
IGLV2-14 -4545.0 -8212.0
IGLV2-18 5165.0 -4216.0
IGLV2-23 4476.0 -5875.0
IGLV2-8 4817.0 -8917.0
IGLV3-1 -5764.0 -8993.0
IGLV3-12 -6620.0 -5525.0
IGLV3-19 2884.0 -7478.0
IGLV3-21 -1967.0 -5619.0
IGLV3-25 -5461.0 -6576.0
IGLV3-27 -8634.0 -4435.0
IGLV4-69 -1909.0 -6359.0
IGLV5-45 5252.0 -9604.0
IGLV6-57 4672.0 -7639.0
IGLV7-43 165.0 2135.0
IGLV7-46 6144.0 -6715.0
IGLV8-61 3943.0 -3641.0
IKBKB -6356.0 -1160.0
IKBKE 3422.0 7754.0
IKBKG -595.0 7203.0
IL10 9226.0 10431.0
IL10RA -10506.0 -7351.0
IL10RB 10086.0 10181.0
IL11RA 3928.0 -9255.0
IL12A 3147.0 -8099.0
IL12RB1 -10018.0 -10649.0
IL12RB2 -10678.0 -9666.0
IL13RA1 6354.0 3540.0
IL15 4243.0 -5326.0
IL15RA 7738.0 301.0
IL16 -9878.0 -8592.0
IL17C -4476.0 2603.0
IL17RA 9934.0 10045.0
IL17RB -3966.0 -706.0
IL17RC 5212.0 -2958.0
IL17RE -3066.0 -335.0
IL18 7946.0 10001.0
IL18BP -6907.0 -7996.0
IL18R1 -10208.0 2501.0
IL18RAP -10986.0 1316.0
IL19 5400.0 8293.0
IL1B 9843.0 323.0
IL1R1 8837.0 9561.0
IL1R2 7717.0 2515.0
IL1RAP -137.0 7646.0
IL1RL1 4851.0 -7621.0
IL1RN 10354.0 9802.0
IL20RB -3801.0 -8203.0
IL21R -10580.0 -10516.0
IL23A 2448.0 -10033.0
IL24 -9597.0 -7293.0
IL27 7689.0 8106.0
IL27RA -5135.0 5710.0
IL2RA 2298.0 -5478.0
IL2RB -10992.0 -10437.0
IL2RG -9921.0 -10217.0
IL31RA -708.0 -7497.0
IL32 -3097.0 -10337.0
IL33 -2225.0 -1120.0
IL3RA -7725.0 -10665.0
IL4 -8327.0 -10394.0
IL4R 2336.0 7941.0
IL5RA -9017.0 -10618.0
IL6R 9817.0 7220.0
IL6ST 8195.0 4822.0
IL7 -8228.0 -5430.0
IL7R -2724.0 -10582.0
IL9R -10074.0 -10257.0
ILF2 6408.0 2915.0
IMPDH1 10166.0 10137.0
IMPDH2 543.0 -9049.0
INPP5D -10748.0 -563.0
INPPL1 9545.0 10037.0
IP6K2 -10614.0 -5581.0
IQGAP1 6734.0 9841.0
IQGAP2 3533.0 9892.0
IRAK1 2858.0 6473.0
IRAK2 -10838.0 -5931.0
IRAK3 9582.0 10412.0
IRF1 2037.0 -10547.0
IRF2 8634.0 6493.0
IRF3 -453.0 -6404.0
IRF4 -4897.0 -8396.0
IRF5 7780.0 7994.0
IRF6 -6421.0 -8510.0
IRF7 -7026.0 -8410.0
IRF8 3971.0 7658.0
IRF9 -7691.0 -9993.0
IRS1 1115.0 1691.0
IRS2 3826.0 10432.0
ISG15 -9687.0 -10630.0
ISG20 -9565.0 -8583.0
IST1 2776.0 6310.0
ITCH -3904.0 5799.0
ITGA2B 8831.0 9692.0
ITGA4 -8536.0 -9695.0
ITGAL -10521.0 -8351.0
ITGAM 10114.0 10483.0
ITGAV 4141.0 7107.0
ITGAX 4703.0 8540.0
ITGB1 -332.0 1996.0
ITGB2 9132.0 10614.0
ITGB3 7696.0 8680.0
ITGB5 4409.0 7405.0
ITGB7 -9718.0 -10214.0
ITK -5396.0 -10354.0
ITLN1 -8675.0 -6281.0
ITPR1 -9755.0 -3689.0
ITPR2 4786.0 9335.0
ITPR3 -8426.0 -7902.0
JAK1 -10460.0 -6095.0
JAK2 8894.0 -2339.0
JAK3 9823.0 8824.0
JAML 9535.0 8574.0
JUN 481.0 -1015.0
JUNB 7420.0 5447.0
JUP -10174.0 -7667.0
KBTBD6 -4372.0 1950.0
KBTBD7 2281.0 6552.0
KBTBD8 -6734.0 1825.0
KCMF1 5611.0 7491.0
KCNAB2 -9357.0 6982.0
KCTD6 6285.0 8491.0
KCTD7 -9638.0 -9919.0
KEAP1 1677.0 6363.0
KIF11 3737.0 2621.0
KIF15 -449.0 425.0
KIF18A -2850.0 622.0
KIF20A 6379.0 5509.0
KIF22 -10509.0 -10695.0
KIF23 8848.0 7278.0
KIF26A 6834.0 -7906.0
KIF2A -6211.0 -747.0
KIF2C 7577.0 4013.0
KIF3A -8157.0 -10124.0
KIF3B 401.0 7605.0
KIF3C -1903.0 8405.0
KIF4A -1608.0 5848.0
KIF5A -6614.0 -7384.0
KIF5B 9763.0 9072.0
KIF5C -3207.0 -10063.0
KIFAP3 -5888.0 -4431.0
KIR2DL1 -10789.0 -8127.0
KIR2DL3 -10425.0 -4407.0
KIR2DL4 -10361.0 4356.0
KIR2DS4 -10995.0 -5686.0
KIR3DL1 -10747.0 -3676.0
KIR3DL2 -10676.0 -8104.0
KIT -10558.0 -7492.0
KL 5898.0 10387.0
KLC1 1637.0 6402.0
KLC2 -4678.0 -6163.0
KLC3 5293.0 7555.0
KLC4 -8715.0 -7444.0
KLHL11 -8639.0 -5691.0
KLHL2 10041.0 9861.0
KLHL20 -8559.0 -7700.0
KLHL21 -3809.0 -685.0
KLHL22 -9362.0 -10073.0
KLHL25 -8531.0 -9408.0
KLHL3 -8412.0 -10585.0
KLHL42 -7950.0 -3516.0
KLHL5 9233.0 3225.0
KLHL9 4068.0 3435.0
KLRB1 -10712.0 -10245.0
KLRC1 -10889.0 -9531.0
KLRC2 -9458.0 -9078.0
KLRD1 -10990.0 -9402.0
KLRF1 -10982.0 -9514.0
KLRG1 -9451.0 -9407.0
KLRK1 -10833.0 -10375.0
KPNA1 3096.0 3012.0
KPNA2 -2381.0 -2173.0
KPNA3 4515.0 4501.0
KPNA4 3199.0 4366.0
KPNA5 -5243.0 -10327.0
KPNB1 67.0 557.0
KRAS 4388.0 5328.0
KRT1 8174.0 5752.0
KSR1 -1842.0 5006.0
KSR2 -9743.0 -472.0
LAG3 -6346.0 -9804.0
LAIR1 -2261.0 9900.0
LAIR2 -9146.0 -4495.0
LAMA5 832.0 -94.0
LAMP1 1557.0 8684.0
LAMP2 9626.0 9234.0
LAMTOR1 10275.0 10468.0
LAMTOR2 6251.0 9811.0
LAMTOR3 9336.0 8131.0
LAT -8158.0 -10401.0
LAT2 8450.0 9858.0
LCK -9185.0 -10569.0
LCN2 9492.0 6870.0
LCP1 9694.0 9469.0
LCP2 5338.0 -3004.0
LEAP2 701.0 -924.0
LGALS3 9840.0 9259.0
LGALS9 7016.0 4726.0
LGMN -2173.0 -1771.0
LILRA1 9680.0 9123.0
LILRA2 10180.0 10188.0
LILRA4 -10660.0 -5011.0
LILRA5 9225.0 10279.0
LILRA6 10127.0 10160.0
LILRB1 8490.0 9291.0
LILRB2 7666.0 10116.0
LILRB3 8925.0 10163.0
LILRB4 9076.0 10539.0
LILRB5 8755.0 8720.0
LIMK1 2972.0 6500.0
LMNB1 10350.0 10018.0
LMO7 -4870.0 -8046.0
LNPEP -9075.0 -5744.0
LNX1 6909.0 -7958.0
LONRF1 585.0 5964.0
LPCAT1 -10615.0 -1283.0
LPO 5708.0 5822.0
LRG1 8829.0 9304.0
LRR1 -1979.0 -4550.0
LRRC41 4228.0 8465.0
LRRC7 -2647.0 1172.0
LRRFIP1 7097.0 6307.0
LRSAM1 1519.0 5303.0
LTA 5225.0 -9641.0
LTA4H 10110.0 10291.0
LTB 897.0 -10096.0
LTBR 10165.0 10583.0
LTF 9350.0 4940.0
LTN1 2289.0 -463.0
LY86 9998.0 9324.0
LY96 9677.0 9581.0
LYN 8483.0 8583.0
LYPLA1 9717.0 9370.0
LYZ 10158.0 5170.0
MADCAM1 -2525.0 1287.0
MAGT1 4037.0 5258.0
MALT1 -1899.0 -9188.0
MAN2B1 6033.0 6605.0
MANBA 8844.0 7868.0
MAOA 9730.0 10208.0
MAP2K1 8861.0 10365.0
MAP2K2 4832.0 6767.0
MAP2K3 8777.0 8502.0
MAP2K4 5525.0 7430.0
MAP2K6 8704.0 10103.0
MAP2K7 -1568.0 2972.0
MAP3K1 380.0 8292.0
MAP3K11 5048.0 8330.0
MAP3K14 -10297.0 -9536.0
MAP3K3 6459.0 9695.0
MAP3K7 2469.0 7237.0
MAP3K8 -7148.0 10028.0
MAPK1 -1086.0 9427.0
MAPK10 6946.0 6199.0
MAPK11 8895.0 6888.0
MAPK12 5297.0 -5399.0
MAPK13 -7306.0 -466.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MAPK7 -9798.0 3379.0
MAPK8 -794.0 -7374.0
MAPK9 -6911.0 1519.0
MAPKAP1 7373.0 6742.0
MAPKAPK2 -10648.0 4888.0
MAPKAPK3 7908.0 10021.0
MARK3 9015.0 9517.0
MASP2 836.0 -2977.0
MAVS 5118.0 9914.0
MCEMP1 10355.0 10554.0
MCL1 8331.0 6386.0
MEF2A 8559.0 9073.0
MEF2C 5395.0 -197.0
MEFV 9121.0 9560.0
METTL7A 6476.0 8678.0
MEX3C -10826.0 -8728.0
MGAM 9062.0 9613.0
MGRN1 2673.0 5555.0
MGST1 10318.0 10658.0
MIB2 -8918.0 -9157.0
MICA -64.0 -5502.0
MICB -1149.0 4615.0
MIF -427.0 -5003.0
MKRN1 9667.0 8088.0
MLEC -220.0 4725.0
MLST8 308.0 1090.0
MME -3693.0 -8367.0
MMP1 8623.0 7665.0
MMP25 7595.0 8922.0
MMP8 5024.0 9987.0
MMP9 8967.0 1371.0
MNDA 10302.0 9902.0
MOSPD2 10095.0 8658.0
MPO 10011.0 5205.0
MRAS -10360.0 23.0
MRC1 -2922.0 4812.0
MRC2 1251.0 -3015.0
MRE11 -103.0 -6016.0
MS4A2 -8308.0 -10092.0
MS4A3 8641.0 -1759.0
MSN -4563.0 7812.0
MT2A -7912.0 -6875.0
MTAP 3682.0 642.0
MTOR -10624.0 -2672.0
MUC1 9675.0 8255.0
MUC12 -9171.0 -8879.0
MUC16 -3838.0 -3439.0
MUC20 3464.0 -5169.0
MUC4 244.0 775.0
MUC5B -6905.0 -2911.0
MUC6 -1039.0 -983.0
MUCL1 -1284.0 2959.0
MVP 8914.0 6884.0
MX1 -10178.0 -10573.0
MX2 -4859.0 -5442.0
MYC 8955.0 225.0
MYD88 8926.0 8524.0
MYH9 -3200.0 7267.0
MYLIP -3400.0 -9301.0
MYO10 9262.0 10223.0
MYO1C 4706.0 3451.0
MYO5A 2173.0 8638.0
MYO9B -3670.0 7822.0
NANOG -579.0 488.0
NAPRT 6733.0 8768.0
NBEAL2 4481.0 7538.0
NCAM1 -10869.0 -7309.0
NCF1 7986.0 3322.0
NCF2 10167.0 10265.0
NCF4 10090.0 10097.0
NCK1 -8084.0 -8497.0
NCKAP1 2316.0 10142.0
NCKAP1L 1901.0 10162.0
NCKIPSD 289.0 -2712.0
NCR1 -11032.0 -10479.0
NCR3 -9714.0 -6322.0
NCR3LG1 -10711.0 -8737.0
NCSTN 9915.0 10361.0
NDC1 -8939.0 -10351.0
NDN 1825.0 5967.0
NDUFC2 7348.0 9008.0
NECTIN2 2774.0 10372.0
NEDD4 -1574.0 7147.0
NEDD4L 4410.0 9142.0
NEFL 7064.0 -8252.0
NEU1 9609.0 10026.0
NF1 -3172.0 5202.0
NF2 -9490.0 -6173.0
NFAM1 9877.0 10409.0
NFATC1 -9820.0 -3625.0
NFATC2 -10949.0 -10428.0
NFATC3 -10649.0 -10621.0
NFKB1 8527.0 5403.0
NFKB2 5450.0 -6553.0
NFKBIA 8114.0 5809.0
NFKBIB -5904.0 1139.0
NFKBIE 5179.0 -8454.0
NHLRC3 4425.0 7076.0
NIT2 -5470.0 -9344.0
NKIRAS1 1465.0 2281.0
NKIRAS2 9577.0 10434.0
NLRC3 -10795.0 -10430.0
NLRC4 10215.0 10499.0
NLRC5 -4707.0 -10102.0
NLRP1 -4418.0 -6987.0
NLRP3 9713.0 9646.0
NLRX1 1862.0 9184.0
NME2 5550.0 1269.0
NOD1 -10556.0 -9537.0
NOD2 9289.0 9320.0
NOS1 -86.0 528.0
NOS3 7751.0 -4608.0
NPC2 8648.0 6362.0
NPDC1 9341.0 -770.0
NPEPPS 8194.0 8724.0
NRAS 8582.0 7708.0
NRG1 7105.0 -2454.0
NRG4 4405.0 4.0
NUP107 -8816.0 -8274.0
NUP133 -5348.0 776.0
NUP153 -6945.0 -3734.0
NUP155 -5317.0 -7756.0
NUP160 -2219.0 -8347.0
NUP188 -9248.0 -9221.0
NUP205 -7213.0 -7389.0
NUP210 -10535.0 -6252.0
NUP214 8257.0 8111.0
NUP35 -4124.0 -8851.0
NUP37 5728.0 6078.0
NUP42 2461.0 -1423.0
NUP43 -3773.0 -8208.0
NUP50 6620.0 2938.0
NUP54 6985.0 -5266.0
NUP58 9614.0 9817.0
NUP62 6407.0 -2545.0
NUP85 2286.0 -2781.0
NUP88 -8115.0 -8802.0
NUP93 -5242.0 -7982.0
NUP98 -1200.0 2149.0
OAS1 -5091.0 -7522.0
OAS2 -10463.0 -10467.0
OAS3 -10320.0 -10702.0
OASL -10110.0 -9520.0
OLFM4 4279.0 7865.0
OLR1 9142.0 -629.0
OPRD1 -7245.0 144.0
OPRM1 6190.0 4645.0
ORAI1 -8363.0 -7067.0
ORAI2 -2897.0 4779.0
ORM1 9208.0 6694.0
ORM2 1731.0 -2088.0
ORMDL3 -10039.0 -8440.0
OSBPL1A -7050.0 -8293.0
OSCAR 9873.0 9943.0
OSM 8836.0 6586.0
OSMR -7699.0 -1587.0
OSTF1 7593.0 8307.0
OTUD5 -6013.0 -4938.0
P2RX1 566.0 10417.0
P2RX7 7506.0 2020.0
P4HB 8507.0 9962.0
PA2G4 5160.0 -928.0
PADI2 10200.0 10268.0
PAFAH1B2 7578.0 8153.0
PAG1 1967.0 6079.0
PAK1 10129.0 7653.0
PAK2 9098.0 8874.0
PAK3 -1475.0 -334.0
PANX1 6838.0 8716.0
PAQR3 -2104.0 2044.0
PCBP2 5133.0 2907.0
PDAP1 3713.0 8107.0
PDCD1 -7335.0 -8133.0
PDCD1LG2 5488.0 -5475.0
PDCD4 -7565.0 -9703.0
PDE12 -8179.0 -4283.0
PDE3B -9089.0 -10606.0
PDE6D 4393.0 7441.0
PDGFA 1176.0 5657.0
PDGFB -8368.0 -7863.0
PDGFRA -825.0 7909.0
PDGFRB -10542.0 -8788.0
PDIA3 7841.0 5995.0
PDPK1 -54.0 8056.0
PDXK 9531.0 9355.0
PDZD11 -3651.0 -3584.0
PEA15 3001.0 -5301.0
PEBP1 -3719.0 -9443.0
PECAM1 7190.0 9387.0
PELI1 8918.0 5667.0
PELI2 7349.0 9515.0
PELI3 -320.0 9317.0
PFKL -4628.0 -3901.0
PGAM1 10347.0 10422.0
PGLYRP1 9124.0 7399.0
PGLYRP2 -8765.0 -3233.0
PGM1 2601.0 6092.0
PGM2 10212.0 10292.0
PGRMC1 6912.0 7496.0
PHB 4244.0 -2118.0
PI3 8852.0 -5909.0
PIANP -3098.0 -559.0
PIAS1 9454.0 7475.0
PIGR 3970.0 5820.0
PIK3AP1 7061.0 8941.0
PIK3C3 4588.0 3248.0
PIK3CA 5168.0 6821.0
PIK3CB 9880.0 9707.0
PIK3CD -932.0 3422.0
PIK3R1 -7314.0 -9108.0
PIK3R2 2369.0 6022.0
PIK3R3 -10971.0 -7175.0
PIK3R4 -624.0 -83.0
PILRA 8099.0 8134.0
PILRB -9850.0 -9661.0
PIM1 10092.0 7166.0
PIN1 -6018.0 434.0
PITPNA 8374.0 6227.0
PJA1 -6117.0 -6871.0
PJA2 7163.0 8067.0
PKM 10317.0 10280.0
PLA2G6 -10438.0 -10350.0
PLAC8 8969.0 10175.0
PLAU 4112.0 3352.0
PLAUR 9724.0 9965.0
PLCG1 -5836.0 -10187.0
PLCG2 -6227.0 6708.0
PLD1 10119.0 10572.0
PLD2 6138.0 9091.0
PLD3 8046.0 6488.0
PLD4 -11002.0 -10493.0
PLEKHO2 6402.0 8506.0
PLPP5 -9164.0 -5630.0
PML -917.0 -9991.0
PNP 9592.0 9563.0
POLR1C -936.0 -9350.0
POLR1D 8801.0 7295.0
POLR2E 8013.0 8218.0
POLR2F 320.0 5451.0
POLR2H 4812.0 -2703.0
POLR2K 7511.0 2990.0
POLR2L 2955.0 6234.0
POLR3A -7506.0 1498.0
POLR3B -3732.0 -354.0
POLR3C 1799.0 -1247.0
POLR3D -8901.0 -9448.0
POLR3E -9965.0 -8825.0
POLR3F 6952.0 -2664.0
POLR3G -7149.0 -4501.0
POLR3GL -7171.0 962.0
POLR3H -5579.0 -9356.0
POLR3K -1331.0 -2064.0
POM121 -9318.0 -4714.0
POM121C -10088.0 -6969.0
POMC 2426.0 -2728.0
POU2F1 -4769.0 4835.0
PPBP 5440.0 6001.0
PPIA 285.0 1417.0
PPIE -3976.0 -8580.0
PPL -2108.0 -3698.0
PPM1B 5181.0 7021.0
PPP1CB 8424.0 7913.0
PPP1CC 9534.0 8032.0
PPP2CA 9766.0 8577.0
PPP2CB 9136.0 9093.0
PPP2R1A 1997.0 5379.0
PPP2R1B 3691.0 1706.0
PPP2R5A -3440.0 4169.0
PPP2R5B 4569.0 7252.0
PPP2R5C -9892.0 -8496.0
PPP2R5D -5620.0 3209.0
PPP2R5E 522.0 2302.0
PPP3CA 3489.0 7766.0
PPP3CB 9261.0 8237.0
PPP3R1 8749.0 9050.0
PPP5C -8001.0 530.0
PRCP 9464.0 9217.0
PRDX4 7205.0 2372.0
PRDX6 9478.0 8747.0
PRKACA 9995.0 10558.0
PRKACB -8479.0 -10448.0
PRKCB -4906.0 9024.0
PRKCD 9710.0 9721.0
PRKCE -10688.0 -925.0
PRKCQ -9967.0 -10691.0
PRKCSH 1054.0 6027.0
PRKDC -9391.0 -8118.0
PRKG1 6638.0 5530.0
PRKG2 -7286.0 -6385.0
PRLR -8514.0 -9184.0
PROS1 8002.0 7705.0
PRR5 -10901.0 -10359.0
PRTN3 10009.0 6834.0
PSAP 8066.0 8239.0
PSEN1 7406.0 9055.0
PSMA1 9165.0 8953.0
PSMA2 9175.0 6486.0
PSMA3 8811.0 -3545.0
PSMA4 8595.0 258.0
PSMA5 6009.0 -5256.0
PSMA6 9365.0 6915.0
PSMA7 6006.0 7700.0
PSMB1 8548.0 3242.0
PSMB10 -972.0 -8733.0
PSMB2 8065.0 5797.0
PSMB3 8817.0 8326.0
PSMB4 4018.0 3039.0
PSMB5 8225.0 9508.0
PSMB6 6959.0 8991.0
PSMB7 9346.0 8950.0
PSMB8 5148.0 -5793.0
PSMB9 -5133.0 -10716.0
PSMC1 7220.0 8544.0
PSMC2 4967.0 6378.0
PSMC3 2824.0 4673.0
PSMC4 -9365.0 -3210.0
PSMC5 2913.0 2050.0
PSMC6 9832.0 7978.0
PSMD1 8509.0 8974.0
PSMD10 6347.0 2957.0
PSMD11 8697.0 9183.0
PSMD12 9648.0 8351.0
PSMD13 7185.0 6511.0
PSMD14 7985.0 5632.0
PSMD2 7347.0 8049.0
PSMD3 3057.0 6067.0
PSMD4 8627.0 9334.0
PSMD5 1520.0 8328.0
PSMD6 9864.0 9375.0
PSMD7 9212.0 6772.0
PSMD8 6905.0 6585.0
PSMD9 7407.0 8869.0
PSME1 -1137.0 -9489.0
PSME2 3614.0 -10267.0
PSME3 9544.0 8452.0
PSME4 -8419.0 -464.0
PSMF1 7685.0 5740.0
PSPN 6888.0 928.0
PSTPIP1 635.0 9877.0
PTAFR 10084.0 10562.0
PTEN 8668.0 9329.0
PTGES2 -4699.0 -4573.0
PTGS2 8500.0 5863.0
PTK2 4992.0 3213.0
PTK2B 2160.0 9588.0
PTPN1 -7223.0 8628.0
PTPN11 3471.0 9688.0
PTPN12 6377.0 9874.0
PTPN13 -7614.0 -7223.0
PTPN14 -908.0 -488.0
PTPN18 -3234.0 9001.0
PTPN2 8577.0 10537.0
PTPN20 312.0 2477.0
PTPN22 -7799.0 6117.0
PTPN23 -6746.0 561.0
PTPN3 -1234.0 2091.0
PTPN4 -10744.0 -10485.0
PTPN6 3230.0 7923.0
PTPN7 -8688.0 -7879.0
PTPN9 -3258.0 9595.0
PTPRA -9952.0 4769.0
PTPRB -9309.0 -1901.0
PTPRC -4530.0 4553.0
PTPRJ 1010.0 9383.0
PTPRN2 7727.0 4489.0
PTX3 9712.0 4622.0
PVR 8049.0 10087.0
PYCARD 8846.0 9930.0
PYGB -6473.0 454.0
PYGL 10308.0 10199.0
QPCT 10273.0 10185.0
QSOX1 9888.0 10475.0
RAB10 9916.0 9959.0
RAB14 8765.0 8436.0
RAB18 9744.0 7495.0
RAB24 5628.0 2552.0
RAB27A 9159.0 9152.0
RAB31 10008.0 10290.0
RAB37 -10867.0 -10259.0
RAB3A 6440.0 9746.0
RAB3D 9091.0 10183.0
RAB44 6119.0 -1305.0
RAB4B -3971.0 4641.0
RAB5B -279.0 7773.0
RAB5C 8923.0 9415.0
RAB6A 8383.0 9332.0
RAB7A 9941.0 9609.0
RAB9B -6342.0 1453.0
RAC1 9345.0 9946.0
RAC2 -1305.0 4460.0
RACGAP1 4139.0 4294.0
RAE1 7170.0 7531.0
RAF1 8083.0 7846.0
RAG1 -10667.0 -8657.0
RALA 8746.0 2764.0
RALGDS -10755.0 -9889.0
RANBP2 457.0 512.0
RANBP9 802.0 6559.0
RAP1A 9691.0 8186.0
RAP1B -3254.0 7324.0
RAP1GAP 9830.0 7311.0
RAP2B -7124.0 -440.0
RAP2C 785.0 5615.0
RAPGEF1 -10785.0 -4187.0
RAPGEF2 5158.0 7949.0
RAPGEF3 -5747.0 5214.0
RASA1 -703.0 7613.0
RASA2 -7886.0 -3395.0
RASA3 -10081.0 -10027.0
RASA4 -8600.0 -10090.0
RASAL1 -3649.0 3963.0
RASAL2 -7035.0 2676.0
RASAL3 -10386.0 -10650.0
RASGEF1A -10682.0 -2489.0
RASGRF1 -7882.0 3486.0
RASGRF2 -3266.0 -10157.0
RASGRP1 -9188.0 -10645.0
RASGRP2 -6869.0 -9348.0
RASGRP3 -4802.0 -9325.0
RASGRP4 10117.0 10286.0
RBBP6 4560.0 -167.0
RBCK1 -2937.0 632.0
RBSN -8580.0 -3332.0
RBX1 1119.0 4750.0
RCE1 -3223.0 -1780.0
RCHY1 8222.0 6775.0
REL -6036.0 7361.0
RELA -2847.0 -1359.0
RELB 6278.0 918.0
RET -9977.0 -5365.0
RETN 10075.0 10034.0
RGL1 9370.0 9936.0
RGL2 4449.0 9300.0
RGL3 9529.0 7778.0
RHOA 9541.0 9090.0
RHOF -10845.0 -10601.0
RHOG 8649.0 8946.0
RHOU 9641.0 10458.0
RICTOR -7204.0 -8306.0
RILP 9520.0 6849.0
RIPK1 -8110.0 -7415.0
RIPK2 8675.0 2009.0
RIPK3 -2562.0 6478.0
RLIM 5145.0 5865.0
RNASE2 10359.0 10657.0
RNASE3 10043.0 8604.0
RNASE6 7700.0 7341.0
RNASEL 7711.0 8745.0
RNASET2 5772.0 5567.0
RNF111 4248.0 6346.0
RNF114 7301.0 1546.0
RNF115 -5629.0 -2349.0
RNF123 3263.0 7618.0
RNF125 -8051.0 -8470.0
RNF126 -7806.0 -7316.0
RNF130 9291.0 9813.0
RNF135 9310.0 10213.0
RNF138 9409.0 2352.0
RNF14 3611.0 8337.0
RNF144B 8880.0 10298.0
RNF19A -7873.0 -6915.0
RNF19B 8421.0 3449.0
RNF213 -10507.0 -10252.0
RNF216 -7199.0 -9744.0
RNF217 9789.0 7924.0
RNF220 -6879.0 -3587.0
RNF25 -2098.0 -981.0
RNF34 -2781.0 -2621.0
RNF4 -8899.0 -5634.0
RNF41 6643.0 9620.0
RNF6 6077.0 5449.0
RNF7 8170.0 9018.0
ROCK1 5871.0 8890.0
RORA -10427.0 -10611.0
RORC 428.0 -9827.0
RPLP0 6333.0 -1009.0
RPS27A -1868.0 -5386.0
RPS6KA1 1245.0 8996.0
RPS6KA2 -5842.0 2331.0
RPS6KA3 1034.0 3942.0
RPS6KA5 70.0 -10393.0
RSAD2 -10269.0 -10398.0
S100A1 -2763.0 -3665.0
S100A11 10016.0 9498.0
S100A12 10367.0 10617.0
S100A8 10362.0 10564.0
S100A9 10316.0 10598.0
S100B -10129.0 814.0
S100P 8625.0 9159.0
S1PR1 -10247.0 -7325.0
SAMHD1 8475.0 7578.0
SAR1B 9412.0 8914.0
SARM1 -9903.0 -10510.0
SCAMP1 6325.0 2268.0
SDCBP 10246.0 10113.0
SEC13 6324.0 5321.0
SEC22B 9017.0 4952.0
SEC23A 8250.0 8136.0
SEC24A 8608.0 8866.0
SEC24B 280.0 5708.0
SEC24C -8540.0 1964.0
SEC24D 8466.0 9932.0
SEC31A 1943.0 6528.0
SEC61A1 8546.0 7506.0
SEC61A2 -8294.0 -8164.0
SEC61B 9260.0 8673.0
SEC61G 8791.0 5259.0
SEH1L 8372.0 -4799.0
SELL 9795.0 9352.0
SEM1 5210.0 6938.0
SERPINA1 10186.0 10295.0
SERPINB1 10330.0 10507.0
SERPINB10 10233.0 9723.0
SERPINB2 10291.0 10534.0
SERPINB6 4741.0 9944.0
SERPING1 533.0 -10700.0
SH2B1 -3893.0 -6025.0
SH2D1A -10479.0 -10681.0
SH2D1B -11001.0 -10639.0
SH3KBP1 2654.0 6905.0
SH3RF1 -3527.0 -3022.0
SHC1 3101.0 5292.0
SHC3 9069.0 -1064.0
SHOC2 7882.0 8016.0
SIAH1 -5582.0 -707.0
SIAH2 9387.0 7192.0
SIGIRR -8187.0 -8512.0
SIGLEC1 -10680.0 -10576.0
SIGLEC10 4446.0 10203.0
SIGLEC11 8436.0 9082.0
SIGLEC12 -1433.0 5781.0
SIGLEC14 9432.0 1567.0
SIGLEC15 9777.0 10043.0
SIGLEC16 10250.0 10302.0
SIGLEC5 9147.0 7119.0
SIGLEC6 -9199.0 -7507.0
SIGLEC7 7377.0 10487.0
SIGLEC8 -2673.0 -4170.0
SIGLEC9 9906.0 10513.0
SIKE1 5752.0 -1551.0
SIPA1 -10104.0 2779.0
SIRPA 10351.0 10576.0
SIRPB1 7561.0 9956.0
SKP1 8911.0 4204.0
SKP2 -4203.0 -2704.0
SLAMF6 -10952.0 -9801.0
SLAMF7 -10401.0 -10511.0
SLC11A1 9804.0 10582.0
SLC15A4 -7633.0 6832.0
SLC27A2 8033.0 -6002.0
SLC2A3 10169.0 9727.0
SLC2A5 7318.0 181.0
SLC44A2 -3421.0 2167.0
SLCO4C1 -9301.0 4048.0
SLPI 9574.0 1116.0
SMAD3 -10166.0 -9199.0
SMARCA4 -4137.0 8319.0
SMURF1 -8349.0 1131.0
SMURF2 -9485.0 -7896.0
SNAP23 9581.0 8746.0
SNAP29 -5542.0 9818.0
SNRPA1 -3497.0 -6914.0
SOCS1 8467.0 6659.0
SOCS2 2960.0 -4731.0
SOCS3 10312.0 10656.0
SOCS5 2203.0 5831.0
SOD1 3597.0 -3501.0
SOD2 9488.0 2250.0
SOS1 2394.0 -4661.0
SOS2 8073.0 8815.0
SP100 2431.0 6566.0
SPRED1 -8378.0 -3713.0
SPRED2 -2639.0 8478.0
SPRED3 -3150.0 -3741.0
SPSB1 -2027.0 858.0
SPSB2 -5424.0 -1034.0
SPTA1 9220.0 7274.0
SPTAN1 -10045.0 -9563.0
SPTB 9406.0 9121.0
SPTBN1 -8781.0 -6351.0
SPTBN2 -6201.0 -2780.0
SPTBN5 -7032.0 -3485.0
SQSTM1 5451.0 -188.0
SRC -4936.0 -8846.0
SRP14 5097.0 7759.0
STAT1 -3982.0 -10718.0
STAT2 -2902.0 -9912.0
STAT3 9401.0 8593.0
STAT4 -10652.0 -10680.0
STAT5A 8323.0 7832.0
STAT5B 4680.0 4956.0
STAT6 195.0 7872.0
STBD1 6327.0 6394.0
STIM1 -9782.0 6145.0
STING1 8496.0 4759.0
STK10 -10751.0 -1875.0
STK11IP -4945.0 7132.0
STOM 2462.0 8162.0
STUB1 -5098.0 -1439.0
STX1A -8692.0 -2626.0
STX3 9788.0 8019.0
STX4 -4764.0 2706.0
STXBP2 9851.0 10088.0
SUGT1 4885.0 5013.0
SUMO1 9138.0 8090.0
SURF4 6833.0 7852.0
SVIP 3352.0 1164.0
SYK 9750.0 10350.0
SYNGAP1 -8010.0 -6580.0
SYNGR1 -5375.0 -4808.0
TAB1 7080.0 3716.0
TAB2 8556.0 6836.0
TAB3 215.0 4794.0
TALDO1 10319.0 10395.0
TANK 9785.0 8152.0
TAP1 -3068.0 -10710.0
TAP2 -7592.0 -10537.0
TAPBP -391.0 911.0
TARM1 9495.0 6302.0
TAX1BP1 7589.0 7124.0
TBC1D10C -10068.0 -10544.0
TBK1 8071.0 5122.0
TCIRG1 253.0 9871.0
TCN1 9143.0 3640.0
TCP1 9179.0 4168.0
TEC 6790.0 9842.0
TGFA 5895.0 9650.0
TGFB1 984.0 3574.0
THEM4 -1580.0 -10466.0
THOP1 -7139.0 -6212.0
TICAM1 6577.0 5314.0
TICAM2 9445.0 5256.0
TIFA 8991.0 2402.0
TIMP1 6709.0 10267.0
TIMP2 10080.0 10603.0
TIRAP -8.0 6185.0
TKFC 6312.0 5992.0
TLN1 5974.0 9916.0
TLR1 10059.0 9241.0
TLR10 -4242.0 -4361.0
TLR2 10239.0 9881.0
TLR3 -9392.0 -9897.0
TLR4 9286.0 10255.0
TLR5 9706.0 9984.0
TLR6 9187.0 9277.0
TLR7 9073.0 -6333.0
TLR8 10249.0 10439.0
TLR9 -10559.0 -4710.0
TMBIM1 8125.0 9006.0
TMC6 -6434.0 -9567.0
TMEM179B 5717.0 -1815.0
TMEM30A 9426.0 8525.0
TMEM63A -1855.0 -9668.0
TNF 855.0 -8625.0
TNFAIP3 -10143.0 -6698.0
TNFAIP6 9826.0 9521.0
TNFRSF11A -8080.0 -1507.0
TNFRSF12A 4305.0 7134.0
TNFRSF13B -3332.0 -5270.0
TNFRSF13C -6138.0 -1597.0
TNFRSF14 -3751.0 -7009.0
TNFRSF17 5457.0 -9240.0
TNFRSF18 2603.0 -9291.0
TNFRSF1A 10046.0 10283.0
TNFRSF1B -1892.0 8266.0
TNFRSF25 -213.0 -10512.0
TNFRSF4 6066.0 -9404.0
TNFRSF8 -5130.0 7478.0
TNFRSF9 -3568.0 -1393.0
TNFSF11 -7547.0 -1017.0
TNFSF12 8521.0 7164.0
TNFSF13 8815.0 9829.0
TNFSF13B 9850.0 7312.0
TNFSF14 -7390.0 -2046.0
TNFSF15 1671.0 -5343.0
TNFSF4 -3977.0 5224.0
TNFSF8 4822.0 -8596.0
TNFSF9 -8844.0 -622.0
TNIP2 -929.0 4907.0
TOLLIP 8936.0 8482.0
TOM1 9316.0 10512.0
TP53 -5246.0 -8954.0
TPP2 -4983.0 -7592.0
TPR -4478.0 -7012.0
TRAC -3310.0 -10643.0
TRAF2 -7822.0 -10338.0
TRAF3 3014.0 -4910.0
TRAF6 -4471.0 1582.0
TRAF7 7176.0 10179.0
TRAIP -8256.0 -8939.0
TRAPPC1 6932.0 9117.0
TRAT1 6974.0 -9441.0
TRAV19 -8655.0 -10178.0
TRAV29DV5 83.0 -10423.0
TRAV8-4 -7052.0 -9962.0
TRBC1 -10279.0 -10323.0
TRBV12-3 -5797.0 -9067.0
TRBV7-9 -3767.0 -6477.0
TREM1 7594.0 8932.0
TREML1 6965.0 8592.0
TREML2 -6764.0 6048.0
TREML4 -2293.0 6682.0
TREX1 4501.0 -2650.0
TRIB3 -7114.0 -4878.0
TRIM10 3616.0 7869.0
TRIM11 -7807.0 -6686.0
TRIM14 -8861.0 -5961.0
TRIM17 -10412.0 -3808.0
TRIM2 3387.0 -5007.0
TRIM21 7812.0 -1089.0
TRIM22 -5596.0 -8103.0
TRIM25 9125.0 8899.0
TRIM26 -9788.0 -7180.0
TRIM3 -3929.0 -1463.0
TRIM32 -9103.0 -9631.0
TRIM34 8346.0 6747.0
TRIM35 -9502.0 -9588.0
TRIM36 -4846.0 -3256.0
TRIM37 -8257.0 -4513.0
TRIM38 6382.0 6446.0
TRIM39 -9742.0 -8426.0
TRIM4 6328.0 -338.0
TRIM41 -6681.0 6547.0
TRIM45 -386.0 -8136.0
TRIM46 5845.0 -9134.0
TRIM5 -7418.0 -2652.0
TRIM56 -6855.0 -7154.0
TRIM6 -8738.0 6055.0
TRIM62 -9368.0 -9011.0
TRIM68 -10253.0 -9781.0
TRIM69 -2568.0 -10100.0
TRIM71 8183.0 10340.0
TRIM8 5342.0 9590.0
TRIM9 -4005.0 -5288.0
TRIP12 2527.0 9197.0
TRPC1 2523.0 -9638.0
TRPM2 9977.0 10050.0
TSPAN14 -3505.0 8543.0
TUBB -6747.0 -3278.0
TUBB4B 7592.0 5692.0
TXK -9126.0 -9892.0
TXLNA -1087.0 -243.0
TXN 9660.0 8103.0
TXNDC5 5836.0 -3635.0
TXNIP -7875.0 -4331.0
TYK2 4043.0 8696.0
TYROBP 6739.0 8642.0
UBA1 5026.0 7870.0
UBA3 10160.0 9196.0
UBA5 3997.0 -5058.0
UBA52 2067.0 260.0
UBA6 5769.0 6471.0
UBA7 -3644.0 -6517.0
UBAC1 7503.0 9603.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2A 8378.0 8872.0
UBE2B 8863.0 6372.0
UBE2C 5494.0 3509.0
UBE2D1 10262.0 10093.0
UBE2D2 5413.0 5174.0
UBE2D3 9631.0 8934.0
UBE2D4 -4568.0 -8075.0
UBE2E1 9885.0 8679.0
UBE2E2 6632.0 2130.0
UBE2E3 5701.0 7288.0
UBE2F 3599.0 8133.0
UBE2G1 3382.0 7080.0
UBE2G2 945.0 -5649.0
UBE2H 4979.0 8492.0
UBE2J1 10343.0 9708.0
UBE2J2 7863.0 9279.0
UBE2K 9809.0 8979.0
UBE2L3 9173.0 8427.0
UBE2L6 -3435.0 -10632.0
UBE2M 3363.0 8550.0
UBE2N 7813.0 4195.0
UBE2O -2046.0 1092.0
UBE2Q1 5452.0 7204.0
UBE2Q2 -7040.0 -9475.0
UBE2R2 8147.0 9175.0
UBE2S 6887.0 3531.0
UBE2V1 8249.0 8108.0
UBE2V2 8803.0 5733.0
UBE2W 9550.0 8060.0
UBE2Z -8053.0 -7521.0
UBE3A 4646.0 7316.0
UBE3B -4550.0 5875.0
UBE3C 7000.0 7344.0
UBE3D -8101.0 -7304.0
UBE4A -3580.0 5457.0
UBOX5 -6838.0 3214.0
UBR1 -6941.0 1802.0
UBR2 -1277.0 3386.0
UBR4 -9246.0 -21.0
UFL1 -617.0 178.0
ULBP3 2236.0 1715.0
UNC13D -69.0 8894.0
UNC93B1 42.0 5485.0
UNKL -5276.0 -6786.0
USP18 -10752.0 -10494.0
VAMP2 -4429.0 -10264.0
VAMP3 9466.0 8623.0
VAMP7 10303.0 10569.0
VAMP8 7797.0 7239.0
VAPA 9859.0 9626.0
VASP 8564.0 7918.0
VAT1 9646.0 10524.0
VAV1 6299.0 7892.0
VAV2 -9043.0 2054.0
VAV3 -7486.0 7780.0
VCL 913.0 8321.0
VCP 7591.0 6702.0
VEGFA 7943.0 7054.0
VHL -700.0 5272.0
VIM 10149.0 10565.0
VNN1 10163.0 10414.0
VPS35L 6316.0 8792.0
VRK3 -2450.0 3426.0
VTN 714.0 1913.0
VWF 3995.0 7559.0
WAS 9521.0 9854.0
WASF1 10267.0 10673.0
WASF2 6329.0 9933.0
WASF3 5357.0 6353.0
WASL -3272.0 1473.0
WDR83 2175.0 4833.0
WIPF1 -7238.0 -2901.0
WIPF2 1332.0 7562.0
WSB1 9732.0 9122.0
WWP1 333.0 -9676.0
XAF1 -8641.0 -10392.0
XRCC5 7806.0 6087.0
XRCC6 6022.0 -236.0
YES1 -10892.0 -9337.0
YPEL5 5177.0 5140.0
YWHAB 9116.0 6191.0
YWHAZ 7112.0 6341.0
ZAP70 -10072.0 -10388.0
ZBP1 -10466.0 -10697.0
ZBTB16 -10578.0 8072.0
ZDHHC9 9607.0 9743.0
ZEB1 -2479.0 -8659.0
ZNRF1 7821.0 8083.0
ZNRF2 -5197.0 1192.0



Membrane Trafficking

Membrane Trafficking
metric value
setSize 555
pMANOVA 5.19e-40
p.adjustMANOVA 1.77e-37
s.dist 0.387
s.low.CRP 0.197
s.high.CRP 0.333
p.low.CRP 2.01e-15
p.high.CRP 3.07e-41




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
VAMP7 10303 10569
PLA2G4A 10226 10618
RAB13 10172 10518
PLIN3 10168 10515
AP1S1 10021 10574
RAB32 10118 10403
SERPINA1 10186 10295
ARF4 10147 10254
AGFG1 10229 10133
ITSN1 9926 10430
GRB2 9960 10389
GNS 9753 10593
RAB31 10008 10290
YWHAE 10079 10158
CTSZ 9796 10451
KDELR1 9879 10352
SORT1 10328 9876
SBF2 9786 10402
RAB1A 10223 9909

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAK1 -9042 -7217
ACBD3 4521 7353
ACTR10 9447 8995
ACTR1A 1291 7735
ACTR2 9004 9240
ACTR3 9818 8294
ADRB2 -10762 -9843
AGFG1 10229 10133
AGPAT3 7444 4388
AKT1 -5096 2421
AKT2 -7693 3004
AKT3 -8346 -9755
ALS2 -2405 6348
ALS2CL 4870 -10047
AMPH 198 10006
ANK1 9056 9344
ANK3 5423 -4595
ANKRD27 -9308 4286
ANKRD28 -8321 -2586
AP1B1 7607 10260
AP1G1 -1729 6706
AP1G2 -1671 -3578
AP1M1 392 8050
AP1M2 1215 549
AP1S1 10021 10574
AP1S2 7206 -5666
AP1S3 -7437 3269
AP2A1 -5326 9611
AP2A2 5529 9467
AP2B1 -8369 3155
AP2M1 7928 9269
AP2S1 8593 9630
AP3B1 8318 10381
AP3S1 9256 8625
AP4B1 -7104 452
AP4E1 7397 8614
AP4M1 -6768 4143
AP4S1 4882 -357
APP 10085 9961
ARCN1 4291 7676
AREG -5505 9162
ARF1 9085 10196
ARF3 7124 9257
ARF4 10147 10254
ARF5 8080 9476
ARF6 -772 2507
ARFGAP1 -2066 -296
ARFGAP2 -7117 -3644
ARFGAP3 2322 4136
ARFIP2 1294 -2246
ARFRP1 -4963 -6627
ARL1 3746 1246
ARPC1A 9171 9991
ARPC2 7187 8262
ARPC3 9674 9506
ARPC4 7777 8635
ARPC5 9932 9762
ARRB1 -5720 3058
ARRB2 8232 9058
ASPSCR1 -743 -4191
AVPR2 3307 -4195
BET1 6957 1985
BET1L -4965 -5604
BICD1 -9266 -1245
BICD2 2764 10214
BIN1 -9716 -9890
BLOC1S1 8239 10111
BLOC1S3 -8796 -8402
BLOC1S4 -7852 -6653
BLOC1S6 9410 8343
BNIP1 3526 -3540
C2CD5 -6435 -4045
CALM1 -4337 1051
CAPZA1 9332 9316
CAPZA2 10077 9039
CAPZB 8393 8843
CBL 1852 8579
CCZ1 2409 7285
CCZ1B 4934 2981
CD3D -7327 -10481
CD3G -8283 -10568
CD4 1506 -6863
CD55 9747 10312
CD59 6386 4199
CENPE -3770 492
CHM 3048 6845
CHML 1075 374
CHMP2A 9715 9488
CHMP2B 8303 5566
CHMP3 8652 9021
CHMP4A 6441 5030
CHMP4B 9666 9765
CHMP5 7394 5917
CHMP6 -3413 6801
CHMP7 -3563 -7134
CLINT1 -3865 5787
CLTA 9206 9264
CLTB 891 6664
CLTC 9482 10359
CLTCL1 10097 9644
CNIH1 9266 8825
CNIH2 2506 2667
CNIH3 -9428 -8506
COG1 -9533 -9241
COG2 3963 1728
COG3 3114 -4075
COG4 -3232 889
COG5 3937 3634
COG6 1615 -87
COG7 7042 7599
COG8 -5751 -901
COL7A1 -442 8394
COPA 6851 10178
COPB1 9548 8670
COPB2 9499 8940
COPE 5686 8054
COPG1 7245 9390
COPG2 8584 9972
COPS2 9383 7627
COPS3 8156 5701
COPS4 6317 5948
COPS5 6344 6899
COPS6 889 3896
COPS7A 3083 7494
COPS7B -6235 -3924
COPS8 3385 -3694
COPZ1 8315 6558
COPZ2 -2992 -9775
CPD 7971 10274
CSNK1D -8768 1189
CTSC -3910 5638
CTSZ 9796 10451
CTTN -1491 5397
CUX1 7781 10485
CYTH1 -10664 -10678
CYTH2 -5491 -275
CYTH3 -10590 -1995
CYTH4 290 6606
DAB2 -1315 10367
DCTN1 -4701 7431
DCTN2 9097 10370
DCTN3 3675 7530
DCTN4 5909 10148
DCTN5 -6881 5731
DCTN6 9751 9405
DENND1A 8537 8228
DENND1B -5182 -6323
DENND1C -5881 -4196
DENND2A -5846 -5035
DENND2C -619 6985
DENND2D -10549 -10519
DENND3 7771 7945
DENND4A -3739 1038
DENND4B -4584 4911
DENND4C -5334 -4689
DENND5A 8933 7373
DENND5B -5074 -5006
DENND6A -3231 7597
DENND6B 5199 1549
DNAJC6 7251 6031
DNASE2 -45 7245
DNM1 5661 -1028
DNM2 -2349 6839
DNM3 1942 8165
DTNBP1 3595 5398
DVL2 -9587 -8307
DYNC1H1 -9811 -4718
DYNC1I1 378 6338
DYNC1I2 8978 9397
DYNC1LI1 8227 7194
DYNC1LI2 909 7271
DYNLL1 6414 7208
DYNLL2 -5827 -2261
EGF 8136 8196
EPN1 5311 9662
EPN2 -8607 -4227
EPS15 5113 6773
EPS15L1 -9182 2731
EREG -2190 5005
EXOC1 9024 8457
EXOC2 -9 -5242
EXOC3 472 5375
EXOC4 3395 8923
EXOC5 7313 6215
EXOC6 10067 9636
EXOC7 -4909 6670
EXOC8 -6622 -999
F5 10339 10599
F8 7904 8494
FCHO1 -958 -7638
FCHO2 7657 8741
FNBP1 -5230 -48
FNBP1L 7579 9275
FTH1 1622 1016
FTL 9418 9788
FZD4 -10151 -6695
GABARAP 9696 8661
GABARAPL2 9925 8820
GAK -4280 4069
GALNT1 7857 7854
GALNT2 7832 9935
GAPVD1 5428 9178
GBF1 -8195 348
GCC1 -2365 674
GCC2 -4825 -7034
GDI1 6489 6456
GDI2 8435 8742
GGA1 -461 6124
GGA2 -10705 -503
GGA3 564 5909
GJB6 -7647 4705
GJC1 2210 817
GJC2 -1390 -2117
GJD3 6631 8053
GNS 9753 10593
GOLGA1 -7014 5795
GOLGA2 -6652 7914
GOLGA4 -4344 -1102
GOLGA5 6759 8402
GOLGB1 -5170 -2548
GOLIM4 603 9928
GORASP1 8524 6879
GOSR1 -5651 3364
GOSR2 -1757 3596
GPS1 -6653 -2413
GRB2 9960 10389
GRK2 3428 7104
GRK3 7770 9038
HBEGF -922 4467
HGS 813 5448
HIP1 7210 9534
HIP1R -9741 -8533
HPS1 1774 5625
HPS4 -7128 -7189
HSPA8 -4222 -8984
IGF2R -5530 9230
IL7R -2724 -10582
ITSN1 9926 10430
ITSN2 4513 6436
KDELR1 9879 10352
KDELR2 9893 7875
KDELR3 -1354 -6629
KIAA0319 -7389 -4520
KIF11 3737 2621
KIF13B -1533 8167
KIF15 -449 425
KIF16B 6483 4873
KIF18A -2850 622
KIF18B 1574 -51
KIF19 -10505 -9709
KIF1B 7790 8663
KIF1C 7961 9111
KIF20A 6379 5509
KIF20B -1910 -5769
KIF21A -9783 -10049
KIF21B -10604 -6590
KIF22 -10509 -10695
KIF23 8848 7278
KIF26A 6834 -7906
KIF26B -10289 -9057
KIF27 2910 -4715
KIF28P -8008 -5405
KIF2A -6211 -747
KIF2C 7577 4013
KIF3A -8157 -10124
KIF3B 401 7605
KIF3C -1903 8405
KIF4A -1608 5848
KIF5A -6614 -7384
KIF5B 9763 9072
KIF5C -3207 -10063
KIF6 3441 2876
KIF9 -1464 5983
KIFAP3 -5888 -4431
KIFC1 1080 -113
KIFC2 2690 -1229
KLC1 1637 6402
KLC2 -4678 -6163
KLC3 5293 7555
KLC4 -8715 -7444
LDLR 2581 7296
LDLRAP1 118 -9996
LMAN1 -2101 -9736
LMAN2 6893 7688
LMAN2L 7489 7830
LNPEP -9075 -5744
LRP2 -392 6762
M6PR -618 -2291
MADD -10948 -8948
MAN1A1 6497 9657
MAN1A2 -6602 1179
MAN1C1 1396 -8830
MAN2A1 1336 -1270
MAN2A2 -4209 7794
MAP1LC3B 6882 8047
MCFD2 7974 9249
MIA2 6400 5836
MIA3 40 -2504
MON1A -7153 -1907
MON1B -1853 7964
MVB12A 7215 9463
MVB12B 2169 4830
MYH9 -3200 7267
MYO1C 4706 3451
MYO5A 2173 8638
MYO6 -8930 -10031
NAA30 -4960 -9386
NAA35 -9522 -8612
NAA38 5422 9519
NAPA 4940 2147
NAPB -4472 1066
NAPG 5219 7040
NBAS -1467 4874
NECAP1 3266 3630
NECAP2 6593 3442
NEDD8 5330 8439
NSF 8767 10358
OCRL 6438 9145
OPTN -8484 -10244
PACSIN1 -11022 -10400
PACSIN2 7884 7763
PAFAH1B1 491 7762
PAFAH1B2 7578 8153
PAFAH1B3 7890 1430
PICALM 9197 10228
PIK3C2A 99 -876
PIP5K1C -4414 4334
PLA2G4A 10226 10618
PLA2G6 -10438 -10350
PLIN3 10168 10515
POLG -10398 -5722
PPP6C 9263 7953
PPP6R1 -4291 7176
PPP6R3 1461 4805
PREB 4312 7535
PRKAB1 -458 4538
PRKAB2 -6078 -3690
PRKAG1 7411 7976
PRKAG2 7267 1382
PUM1 -2856 6351
RAB10 9916 9959
RAB11A 9367 8536
RAB11B 1061 4700
RAB12 7246 1150
RAB13 10172 10518
RAB14 8765 8436
RAB18 9744 7495
RAB1A 10223 9909
RAB1B 8291 9474
RAB21 7164 6786
RAB27A 9159 9152
RAB27B -6595 4754
RAB30 -9823 -7791
RAB31 10008 10290
RAB32 10118 10403
RAB33A -10259 -9079
RAB33B 8566 5483
RAB35 -5746 3696
RAB36 3694 2526
RAB38 -7625 -1532
RAB39A 9485 8386
RAB39B -8852 -10419
RAB3A 6440 9746
RAB3GAP1 9145 6282
RAB3GAP2 4864 7377
RAB3IP 2883 6198
RAB41 -3046 -2678
RAB43 3769 5508
RAB4A 8673 6735
RAB5A 9230 7808
RAB5B -279 7773
RAB5C 8923 9415
RAB6A 8383 9332
RAB6B 3094 7305
RAB7A 9941 9609
RAB7B -9067 5680
RAB8A 1690 6186
RAB8B 6481 8127
RAB9A 5902 5709
RAB9B -6342 1453
RABEP1 -10037 -7464
RABEPK 2549 6617
RABGAP1 -824 5647
RABGEF1 7522 7888
RAC1 9345 9946
RACGAP1 4139 4294
RALA 8746 2764
RALGAPA2 7931 9867
RALGAPB -7172 1158
REPS1 -9785 -1895
REPS2 2786 8377
RGP1 -5159 7801
RHOBTB3 -10974 -5531
RHOQ 10030 8943
RIC1 4473 8485
RIN1 3246 9787
RIN2 9120 10172
RINL -10133 -8101
RINT1 4454 -8906
RPS27A -1868 -5386
SAR1B 9412 8914
SBF1 -10005 -8548
SBF2 9786 10402
SCARB2 7527 7411
SCFD1 6826 7619
SCOC 9126 -2347
SEC13 6324 5321
SEC16A -6613 6860
SEC16B -340 3720
SEC22A 5519 1741
SEC22B 9017 4952
SEC22C 2177 1557
SEC23A 8250 8136
SEC23IP 6616 2151
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SEC31A 1943 6528
SERPINA1 10186 10295
SFN 4316 -5611
SH3D19 3393 -1484
SH3GL1 6353 8238
SH3KBP1 2654 6905
SLC2A8 -9818 -10384
SNAP23 9581 8746
SNAP29 -5542 9818
SNAPIN 8469 8664
SNF8 6092 7999
SNX18 -4652 8868
SNX2 8557 9755
SNX5 -28 5823
SNX9 -3423 5481
SORT1 10328 9876
SPTA1 9220 7274
SPTAN1 -10045 -9563
SPTB 9406 9121
SPTBN1 -8781 -6351
SPTBN2 -6201 -2780
SPTBN5 -7032 -3485
SRC -4936 -8846
STAM 2880 1495
STAM2 8313 7133
STON1 -4325 2581
STON2 -8342 4103
STX10 9254 10297
STX16 3962 3629
STX17 -2656 -9125
STX18 3809 8897
STX4 -4764 2706
STX5 6777 7536
STX6 3663 9472
STXBP3 9718 8688
SURF4 6833 7852
SYNJ1 1280 7746
SYNJ2 -6719 -7296
SYS1 -3153 -1279
SYT1 7846 6678
SYT11 -10327 -2
SYT2 -7268 -5231
SYTL1 -8112 -8998
TBC1D1 3483 8464
TBC1D10A -10727 -9177
TBC1D10B 5424 8854
TBC1D10C -10068 -10544
TBC1D13 -8244 5356
TBC1D14 9185 9726
TBC1D15 8943 2916
TBC1D16 39 7045
TBC1D17 -6518 -8314
TBC1D2 9139 10519
TBC1D20 -5268 1442
TBC1D24 749 4875
TBC1D25 -10387 -4445
TBC1D3 837 525
TBC1D4 -1540 -10331
TBC1D7 7070 8260
TBC1D8B -288 649
TF 2007 3922
TFG 9720 8105
TFRC 3905 5758
TGFA 5895 9650
TGOLN2 6907 10123
TJP1 -85 -2268
TMED10 4984 4383
TMED2 6691 7410
TMED3 3770 4652
TMED7 9644 9106
TMED9 7191 9462
TMEM115 3217 3929
TMF1 4265 5362
TOR1A 8179 8469
TOR1B -8015 266
TPD52 -5165 -6821
TPD52L1 -6352 3475
TRAPPC1 6932 9117
TRAPPC10 -10367 -4001
TRAPPC11 7303 8864
TRAPPC12 -306 6210
TRAPPC13 5140 2337
TRAPPC2 -9388 -4103
TRAPPC2L 4084 340
TRAPPC3 8513 8500
TRAPPC4 -6015 -5250
TRAPPC5 -685 471
TRAPPC6A -1341 -9288
TRAPPC6B 6911 6051
TRAPPC8 5637 8631
TRAPPC9 3787 8190
TRIP10 2447 2170
TRIP11 950 4162
TSC1 -5608 223
TSC2 -2640 -1107
TSG101 9865 7776
TXNDC5 5836 -3635
UBA52 2067 260
UBAP1 9245 9187
UBB 7788 3835
UBC 2562 2822
UBQLN1 6829 6120
UBQLN2 8190 2894
ULK1 395 8382
USE1 -739 -2569
USO1 8607 7741
USP6NL 7087 7068
VAMP2 -4429 -10264
VAMP3 9466 8623
VAMP4 7842 7025
VAMP7 10303 10569
VAMP8 7797 7239
VPS25 8588 9314
VPS28 5467 4829
VPS36 3782 -1712
VPS37A 8256 7697
VPS37B -9060 3262
VPS37C 9329 8849
VPS45 8107 4897
VPS4A 330 3807
VPS4B 6755 6176
VPS51 -8721 -7339
VPS52 -1767 842
VPS53 -6455 255
VPS54 9881 9119
VTA1 8205 7811
VTI1A -5308 7940
WASL -3272 1473
YIPF6 8155 7019
YKT6 1766 6226
YWHAB 9116 6191
YWHAE 10079 10158
YWHAG 9489 10473
YWHAH 9385 9379
YWHAQ -6372 -2552
YWHAZ 7112 6341
ZW10 4728 3709



Metabolism

Metabolism
metric value
setSize 1758
pMANOVA 1.93e-34
p.adjustMANOVA 5.26e-32
s.dist 0.224
s.low.CRP 0.17
s.high.CRP 0.145
p.low.CRP 1.72e-32
p.high.CRP 4.24e-24




Top 20 genes
Gene low CRP high CRP
PLBD1 10356 10674
PPARG 10358 10670
IDH1 10341 10649
MGST1 10318 10658
CTSA 10310 10636
VCAN 10280 10667
PGD 10324 10568
IMPA2 10277 10611
CD36 10363 10493
HADHB 10224 10621
PLA2G4A 10226 10618
CYP1B1 10171 10672
GNA15 10227 10612
PLB1 10170 10628
PGAM1 10347 10422
HSD3B7 10138 10609
FAH 10143 10595
DSE 10096 10632
TALDO1 10319 10395
GAPDH 10183 10532

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAAS -4220 -2848
AACS -6141 2931
AANAT 1342 1093
AASDHPPT 5201 3079
AASS -7263 -9449
ABCA1 4951 6830
ABCB1 -10965 -10420
ABCB4 -8019 -3110
ABCB7 4386 -56
ABCC1 -3572 1312
ABCC2 -2800 -2702
ABCC3 -4603 7268
ABCC5 -6370 862
ABCD1 5996 7409
ABCD4 -6320 -5354
ABCG2 -6606 -1925
ABHD10 3510 -915
ABHD14B -2464 -7455
ABHD3 8948 6671
ABHD4 -1813 7071
ABHD5 7194 8817
ABO 2711 2141
ACAA1 7355 9532
ACAA2 6098 7666
ACACA 829 7444
ACACB -9101 -7479
ACAD10 7338 5940
ACAD11 -6277 -7640
ACAD8 -4689 -672
ACAD9 5414 4340
ACADL -1148 4496
ACADM 8574 3014
ACADS -621 6099
ACADSB -6354 -8521
ACADVL 9301 9478
ACAT1 8823 4736
ACAT2 6310 -2016
ACBD4 4093 -3230
ACBD5 -3464 2751
ACBD6 -8804 -9501
ACBD7 1988 6303
ACER1 -5318 -7883
ACER2 -4435 1384
ACER3 10198 10258
ACLY -3480 8333
ACMSD -4439 2949
ACO2 4747 4737
ACOT1 -7538 -6515
ACOT11 -4097 1879
ACOT13 9461 6798
ACOT2 -9931 -6571
ACOT4 -7082 -9355
ACOT7 -3916 -4645
ACOT8 5734 9612
ACOT9 6782 7802
ACOX1 9058 9176
ACOX2 9378 10638
ACOX3 -232 7566
ACOXL 6582 1899
ACP5 -1222 -4876
ACP6 -3860 -7528
ACSBG1 -6230 -1152
ACSF2 -9944 -5903
ACSF3 -3777 2610
ACSL1 10178 9937
ACSL3 8662 9192
ACSL4 9875 9975
ACSL5 -6544 -5467
ACSL6 7022 -8092
ACSM1 -6428 -7599
ACSM2A 2143 9085
ACSM2B 324 318
ACSM3 -7607 -4969
ACSM6 -1965 7099
ACSS1 -10709 -9492
ACSS2 10323 10276
ACSS3 8605 9804
ACY1 5098 -5857
ACY3 -8432 -5459
ADA -10750 -9931
ADAL -4604 -8120
ADCY2 -3835 2899
ADCY3 9752 10224
ADCY4 4464 2329
ADCY5 -10012 -4366
ADCY6 -5852 -3739
ADCY7 -9455 -1458
ADCY9 -8919 1933
ADH1B 192 2319
ADH5 -6095 -1740
ADHFE1 -549 -2485
ADI1 7378 7419
ADIPOR1 9991 9671
ADIPOR2 -2625 8930
ADK -1264 -9143
ADO 3282 -2940
ADPGK 4070 8876
ADPRM -222 -7379
ADRA2A -4933 4150
ADSL 9232 4663
AFMID 4102 8267
AGK -8892 -10246
AGL -5887 971
AGMAT 139 -5056
AGPAT1 5231 9255
AGPAT2 9571 10463
AGPAT3 7444 4388
AGPAT4 -10656 -980
AGPAT5 -3592 -6740
AGPS 7127 7704
AGRN -10089 -10536
AHCY 419 327
AHCYL1 4949 8470
AHR 8112 9783
AHRR -891 1757
AIMP1 7312 -5118
AIMP2 6547 729
AIP -7421 -3297
AK1 -3243 -8345
AK2 9272 4639
AK4 9900 10149
AK5 -8002 -9029
AK6 4416 47
AK9 -5054 2926
AKAP5 -10817 -10361
AKR1A1 3755 -429
AKR1B1 -9090 -9817
AKR1B15 6446 2159
AKR1C1 5170 -820
AKR1C2 -4189 -4494
AKR1C3 -10816 -7648
AKR7A2 -1599 1484
AKR7L 1493 -1329
AKT1 -5096 2421
ALAD 5688 9906
ALAS1 9393 6864
ALAS2 3859 8952
ALB 5157 1598
ALDH18A1 -9021 -6083
ALDH1A1 -8683 -10694
ALDH1B1 -8472 -9485
ALDH1L2 5683 6193
ALDH2 8954 9744
ALDH3A2 6113 4015
ALDH3B1 9122 10008
ALDH4A1 7906 10333
ALDH6A1 -483 7018
ALDH7A1 252 -1649
ALDH9A1 3634 3388
ALDOA 10140 10121
ALDOB -4339 3084
ALDOC 3900 -6356
ALOX12 6136 7443
ALOX12B -3969 -5752
ALOX15 -5374 -9427
ALOX15B 7208 9628
ALOX5 9735 9772
ALOX5AP 8526 7162
AMACR -9979 -2155
AMD1 7470 1852
AMDHD1 -3924 2375
AMN -1633 -2567
AMPD2 2879 6972
AMPD3 8883 9878
AMT -5955 -4519
ANGPTL4 -7888 2021
AOC1 4561 3551
AOC2 4657 1146
AOC3 254 -2056
APIP 9427 7371
APOA2 7224 7075
APOE -4921 3265
APOM 4751 4731
APRT 3186 -4197
ARF1 9085 10196
ARF3 7124 9257
ARG1 9516 8264
ARG2 -3478 7437
ARNT 6732 10010
ARNTL -10164 -1541
ARSA 6282 1069
ARSB 8290 9046
ARSD 7388 8269
ARSG -4 -7971
ARSJ -5813 -6407
ARSK -7489 -9464
ARV1 5131 5075
AS3MT -2064 -6420
ASAH1 9394 10144
ASAH2 -6475 -6478
ASL -1542 9094
ASNS 3189 -6265
ASPA 2326 -1324
ASRGL1 6548 2847
ATIC 1721 -9614
ATP5F1A 9557 6994
ATP5F1B 8684 6919
ATP5F1C 9580 8671
ATP5F1D 474 359
ATP5F1E 6027 6878
ATP5MC1 5471 -6148
ATP5MC2 1987 2992
ATP5MC3 7250 7383
ATP5ME -322 5177
ATP5MF 7383 8461
ATP5MG 8134 7589
ATP5PB 9493 9015
ATP5PD 9734 8460
ATP5PF 7570 8666
ATP5PO 9184 6042
AUH -9569 5675
AZIN1 6823 8066
AZIN2 -664 -10502
B3GALNT1 2892 8344
B3GALT1 3590 -4753
B3GALT2 4292 -6383
B3GALT4 -6490 7269
B3GALT6 -4374 -6890
B3GAT1 -10616 -7001
B3GAT2 2277 -6321
B3GAT3 -948 -2368
B3GNT2 6491 4534
B3GNT4 -3531 -9653
B3GNT7 -10766 -10193
B4GALNT2 -4045 2852
B4GALT1 -3872 6820
B4GALT2 -2272 31
B4GALT3 -7395 -8398
B4GALT4 -6517 3566
B4GALT5 9525 9637
B4GALT6 -10803 131
B4GALT7 -2683 -6283
B4GAT1 -1787 -2379
BCAT1 -50 10278
BCAT2 1824 -732
BCKDHA 1187 6922
BCKDHB -2852 -10200
BCKDK 9596 10273
BCO2 -8749 -2570
BDH1 -2447 -10075
BDH2 -896 -9968
BLVRA 9610 5412
BLVRB 10234 10007
BMX 7713 9372
BPGM 9883 9454
BPHL 4297 -3818
BPNT1 618 3399
BRIP1 -7901 -8416
BSG 9321 9898
BST1 10348 10335
BTD -10140 -10299
CA1 10237 10011
CA13 7021 3616
CA14 -8658 -149
CA2 1256 5218
CA4 7084 9371
CA5B -7522 -6630
CA6 7830 -7666
CACNA1A 1267 -1619
CACNA1C -10080 -8263
CACNA1D 4525 -1206
CACNA1E 8007 7734
CACNA2D2 -10834 -9945
CACNB2 3180 1103
CACNB3 2728 -1868
CAD -5411 -8350
CALM1 -4337 1051
CARM1 9302 10024
CARNMT1 -3882 -9187
CARNS1 -8707 -9361
CAV1 1798 -1413
CBR1 6575 1365
CBR3 149 -9513
CBR4 1848 4465
CBS 892 6123
CCNC 8958 4374
CD320 -6807 -9725
CD36 10363 10493
CD38 -9260 -10154
CD44 9109 9660
CDA 10040 10360
CDIPT 4777 5211
CDK19 -268 9996
CDK8 -1289 2360
CDS1 4952 -2445
CDS2 4321 8637
CEMIP -5255 -8656
CEPT1 7815 6484
CERK -8098 -2754
CERS2 9287 9555
CERS3 1516 -2225
CERS4 -7636 -2971
CERS5 -566 3745
CERS6 5284 5804
CERT1 8580 8411
CES1 10326 9607
CES2 2185 9711
CES3 -10537 -4824
CHAC2 2320 -6989
CHD9 -7440 4616
CHDH -2806 6337
CHKA 5361 8387
CHKB 682 -4483
CHP1 8833 10625
CHPF -8663 -9426
CHPF2 6927 7459
CHPT1 8237 8809
CHST11 -962 6995
CHST12 -10977 -10688
CHST13 4114 9608
CHST14 -8335 2604
CHST15 9402 10090
CHST2 -10937 -7021
CHST5 86 4760
CHST6 1538 -3637
CHST7 -10728 -7765
CHSY1 8912 8026
CIAO1 -7309 -1663
CIAO2B -892 954
CIAO3 -5708 -1510
CIAPIN1 -3075 -6
CKB -10998 -9763
CKMT2 1142 -5338
CLOCK -6053 -3825
CMBL 7631 6246
CMPK1 4459 -1900
CNDP2 207 -664
COASY 7168 9022
COMT 8254 9173
COQ10A -8775 -8783
COQ10B 6069 3637
COQ2 8048 8908
COQ3 -5752 -7229
COQ5 6126 8280
COQ6 -7865 -9319
COQ7 5449 3968
COQ9 -4700 -3023
COX10 -4250 -970
COX11 -5218 -9151
COX14 3006 -1658
COX15 6201 10184
COX16 8909 998
COX18 4592 -2426
COX19 1920 -3944
COX20 3257 -2193
COX4I1 5132 3979
COX5A 7687 7980
COX5B 6345 7810
COX6A1 3840 6505
COX6B1 6445 7034
COX6C 6357 4173
COX7A2L 9037 8303
COX7B 6183 6675
COX7C 910 974
COX8A 5588 7834
CPNE1 -7255 -6504
CPNE3 8631 6794
CPNE7 649 -7412
CPOX 554 -2448
CPS1 607 -4976
CPT1A 2948 6756
CPT1B 586 -4472
CPT2 5476 9156
CPTP -1778 -230
CRAT 7800 9800
CREBBP -9358 1958
CRLS1 10232 9577
CROT -9760 -10594
CRYL1 6679 7087
CRYM -6392 9591
CS 7611 6549
CSAD 7984 8597
CSGALNACT1 5893 5269
CSGALNACT2 9659 9410
CSNK1G2 -7707 1858
CSNK2A1 1926 9964
CSNK2A2 136 9661
CSNK2B 4787 4600
CSPG4 -7234 -3407
CTH -5303 -9239
CTPS1 7 -4128
CTPS2 -678 7385
CTRC -7878 -7742
CTSA 10310 10636
CUBN 3637 -8340
CYB5A -2132 -5140
CYB5B -7519 -3898
CYB5R3 7459 10015
CYC1 -437 4720
CYCS 7831 2324
CYP1A2 -744 4997
CYP1B1 10171 10672
CYP27A1 5784 2844
CYP2A6 -4444 -8186
CYP2C9 4176 7785
CYP2D6 -2583 -7028
CYP2E1 -671 -9982
CYP2R1 -9251 -308
CYP2S1 -4408 -5573
CYP2U1 -10657 -10266
CYP3A43 2164 5955
CYP3A5 9306 -5164
CYP46A1 3304 1787
CYP4F12 8279 -9242
CYP4F22 -10929 -10406
CYP4F3 6079 4596
CYP4F8 -4489 1534
CYP4V2 -6516 -5389
CYP51A1 8344 8766
CYP7B1 -6090 -4311
CYSLTR2 1991 -7665
D2HGDH -1735 -4104
DARS1 9222 1575
DBH -4508 -9596
DBI 3542 9499
DBT 563 -1705
DCK -3180 -4999
DCTD -1481 -5953
DCTPP1 2977 1250
DCXR 3537 -1189
DDAH2 -1907 9545
DDHD1 -7999 -9193
DDHD2 -7240 -10059
DDO 5306 -7349
DECR1 8621 7403
DECR2 -3230 880
DEGS1 8935 6383
DEGS2 -10655 -4970
DERA 9456 9825
DGAT1 879 2318
DGAT2 10122 9982
DGUOK 3953 5330
DHCR24 -2264 6589
DHCR7 5124 8197
DHFR 8044 8420
DHFR2 -2935 4481
DHODH 1604 -387
DHRS7B 8891 9075
DHTKD1 4223 7032
DIO1 2548 -5672
DLAT 1761 3102
DLD 8939 9407
DLST -9444 -2022
DMAC2L -3270 -3208
DNM2 -2349 6839
DNPH1 4053 -5724
DPEP2 -7575 -7040
DPEP3 -509 -9183
DPYD 9903 10022
DSE 10096 10632
DSEL 7572 -6089
DTYMK -5634 -4778
DUOX1 -8164 -8017
DUT -1230 -4662
EBP -9864 -9955
ECHS1 4495 -1054
ECI1 818 697
ECI2 -7278 -9201
ECSIT 5443 4562
EEF1E1 3565 3869
EEFSEC -6081 -5395
EHHADH 5018 8755
ELOVL1 5593 8179
ELOVL3 10220 9260
ELOVL4 1844 -9329
ELOVL5 7670 5549
ELOVL6 -10674 -6390
ELOVL7 6773 7878
ENO1 10259 9450
ENO2 2467 -7760
ENO3 -4801 -4769
ENOPH1 -2437 -6944
ENPP1 -9754 -248
ENPP2 4361 4777
ENPP3 -5240 -10421
ENPP6 -305 2782
ENTPD1 9787 9358
ENTPD4 800 -3229
ENTPD5 -3775 -3687
ENTPD6 862 -7160
ENTPD7 7270 9195
EP300 -2315 7280
EPHX1 -5315 -8405
EPHX2 -1499 -10373
EPM2A -6288 -8172
EPRS1 3916 1660
ERCC2 -974 6111
ESD 9511 7617
ESRRA 2508 6978
ESYT1 -10020 -9944
ESYT2 -8724 -8572
ETFA 9339 9616
ETFB 9144 9286
ETFDH 10012 10191
ETHE1 9391 10081
ETNK1 3981 424
ETNK2 -9574 -6401
EXT1 5076 8271
EXT2 -1420 -555
FA2H 3440 -1414
FAAH 1400 -7239
FAAH2 7471 -6536
FABP2 -4153 4235
FABP3 -9380 -7048
FABP5 6772 7102
FADS1 6968 9327
FADS2 1344 7263
FAH 10143 10595
FAHD1 1616 -1492
FAM120B -5237 1265
FAR1 10144 9605
FAR2 10203 9236
FASN -4442 -2375
FAU -1127 -1637
FBP1 4653 9262
FDFT1 6738 9135
FDPS 2989 7591
FDX1 6054 -653
FDX2 -1694 -7020
FDXR 9148 3744
FECH 8581 7860
FH 5441 6335
FHL2 -1874 5631
FIG4 9790 10585
FITM1 -6627 -4138
FITM2 -4015 -3895
FLAD1 -3641 -2027
FLVCR1 -8512 -1422
FMO3 2263 1957
FOLR2 8927 -10004
FPGS -7113 -9038
FTCD -3528 -7317
FUT1 8010 5953
FUT10 34 -441
FUT11 -10954 -10396
FUT2 -5061 -7500
FUT4 7341 7188
FUT7 8972 8557
FXN -7975 -10076
G0S2 6743 6235
G6PC 7956 7740
G6PC3 5886 5835
G6PD 9299 10309
GAA 8463 8516
GADL1 -3678 1017
GALC 7969 10450
GALE 1797 8288
GALK1 8209 10332
GALT -1401 -8485
GAMT -2129 -8940
GAPDH 10183 10532
GART 488 6283
GATM -9653 1065
GBA 9467 9882
GBA2 -6594 5916
GBE1 8804 8490
GCAT -4125 4942
GCDH -6246 -1486
GCH1 781 -6037
GCHFR 624 6973
GCK -553 1673
GCLC -9254 -6727
GCLM 1993 6688
GCSH -6717 -3907
GDA 5495 5268
GDE1 9177 8852
GDPD1 -5380 -1696
GDPD3 7486 3523
GDPD5 -7604 -10039
GGCT 7067 -4675
GGPS1 7824 1722
GGT1 10054 10098
GGT5 -401 3250
GGT7 -3508 -7280
GK 10064 9859
GLA 7742 9617
GLB1 9395 10125
GLB1L -2931 4158
GLCE 9871 9976
GLDC 7851 -4922
GLIPR1 10116 7714
GLO1 3425 4233
GLRX 8610 8606
GLRX5 9657 7720
GLS -650 -10634
GLS2 90 -7142
GLTP 7173 10376
GLUD1 6875 6482
GLUL 9630 10548
GLYAT 7339 5935
GLYCTK -7326 3530
GM2A 9951 10624
GMPR 9333 6852
GMPR2 5360 8217
GMPS -142 -604
GNA11 5927 -295
GNA15 10227 10612
GNAI1 5305 5103
GNAI2 8368 9095
GNAQ 10128 9401
GNAS 4056 6487
GNB1 7951 9297
GNB2 8365 8530
GNB3 9486 -8169
GNB4 9757 8191
GNB5 -762 -205
GNG10 10307 10252
GNG11 4608 5846
GNG2 -10288 -2836
GNG3 6662 1225
GNG4 -1513 -1627
GNG5 9805 9666
GNG7 -5188 -5336
GNG8 -5154 2284
GNGT2 -10923 -9575
GNMT 3346 2819
GNPAT 7150 9346
GNPDA1 9559 9635
GNPDA2 719 -8666
GNS 9753 10593
GOT1 -7300 -6250
GOT2 -491 -6140
GPAM -8942 -5191
GPAT2 -4284 -4175
GPAT3 9824 7397
GPAT4 -7112 6041
GPC1 -7727 -2335
GPC2 -1014 -9320
GPC4 -5640 -8045
GPCPD1 9563 9885
GPD1 -4549 -370
GPD1L -4573 -6926
GPD2 7686 9569
GPHN -5845 -4754
GPI 3695 7384
GPS2 -3941 -2386
GPT -6058 -7542
GPT2 5196 4492
GPX1 9841 9615
GPX2 -1463 -2988
GPX4 5120 3939
GRHL1 -1957 -1386
GRHPR 2207 -399
GSR 9685 10272
GSS 3136 1464
GSTA4 -8665 -2713
GSTK1 7504 -3268
GSTM1 -1041 -362
GSTM2 -3761 -9414
GSTM3 5380 -1480
GSTM4 -1334 2605
GSTM5 -140 3436
GSTO1 9989 10215
GSTO2 -7842 1378
GSTP1 2629 -1335
GSTZ1 7362 8245
GUK1 4704 1935
GUSB 3888 9979
GYG1 9967 10059
GYS1 7108 8360
HAAO 9867 8665
HACD1 6094 7360
HACD2 -793 4277
HACD3 -6965 -8969
HACD4 6423 7503
HACL1 -2709 -9733
HADH -8309 -8511
HADHA 9533 10380
HADHB 10224 10621
HAGH 5635 2617
HAL 4538 7318
HAS3 -9172 -2769
HDAC3 7060 7743
HDC -4777 -10114
HELZ2 -10149 -8681
HEXA 1499 2409
HEXB 9686 9967
HGD 1775 -360
HIBADH -4792 -4747
HIBCH 3004 -558
HILPDA -57 -2458
HK1 9556 10256
HK2 9771 10470
HK3 10197 10277
HLCS -10771 -6963
HMBS 6360 5106
HMGCL 5616 8110
HMGCR 8233 8629
HMGCS1 3863 2380
HMMR 3097 4182
HMOX1 6215 10321
HMOX2 -9635 -10507
HNMT 10137 9504
HPD 8956 5393
HPGD 1547 7850
HPRT1 9151 7887
HPSE 9308 10055
HS2ST1 4628 7145
HS3ST1 -5619 -1139
HS3ST2 4750 5220
HS3ST3A1 -9523 -5830
HS3ST3B1 -10681 -7168
HS6ST1 -7158 6504
HSCB 6432 5031
HSD11B2 7493 6610
HSD17B1 -1265 -2218
HSD17B10 6214 6724
HSD17B11 8970 8322
HSD17B12 7661 7516
HSD17B13 3610 8121
HSD17B2 699 4654
HSD17B4 9650 10264
HSD17B7 -845 -7421
HSD17B8 -3129 -7260
HSD3B7 10138 10609
HSP90AA1 5650 1245
HSP90AB1 4616 -5342
HSPG2 -8564 -3950
HTD2 1939 -1885
HYAL1 -3857 4281
HYAL2 8701 10550
HYAL3 8070 4386
HYKK 1882 -5308
IARS1 -7684 -8609
IDH1 10341 10649
IDH2 -5977 554
IDH3A 5493 -1148
IDH3B 2500 -1159
IDH3G 2782 3946
IDI1 9201 7719
IDO1 -6514 -9699
IDO2 2466 -4400
IDS -8382 -5645
IDUA 1922 -6114
IL4I1 1687 -9877
IMPA1 5558 334
IMPA2 10277 10611
IMPDH1 10166 10137
IMPDH2 543 -9049
INMT 5573 -4704
INPP1 -2894 2670
INPP4A -10669 -6036
INPP4B 2393 -10234
INPP5A -1181 6398
INPP5B -9344 -2850
INPP5D -10748 -563
INPP5E 16 -8060
INPP5F -4623 1416
INPP5K -1032 -4246
INPPL1 9545 10037
INSIG1 -10677 -5462
INSIG2 8472 8040
IP6K1 -6006 1286
IP6K2 -10614 -5581
IPMK 8722 8214
IPPK -2919 5711
IQGAP1 6734 9841
ISCA1 7192 5785
ISCA2 8334 8672
ISCU 2398 517
ISYNA1 6090 -8225
ITPA -5861 -2522
ITPK1 4623 9253
ITPKB -10355 -10227
ITPKC 6673 10446
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
IVD -10699 -9686
IYD 6924 2381
KARS1 8005 -2267
KCNB1 6084 1366
KCNG2 7429 10669
KCNJ11 -141 2587
KDSR 7726 -7835
KHK -9079 -9026
KMO -989 -2854
KPNB1 67 557
KYAT1 2682 -3398
KYAT3 7885 5796
KYNU 8219 10003
L2HGDH -852 -7238
LARS1 7998 -4102
LBR 9305 8261
LCLAT1 2588 2682
LDHA 10284 9549
LDHAL6A -995 614
LDHB 2425 -9752
LDLR 2581 7296
LGMN -2173 -1771
LHPP 6301 -1033
LIAS 6917 -2913
LIPE -7484 -8741
LIPH -6833 5108
LIPT1 1568 -10053
LIPT2 -1768 -6952
LMBRD1 8494 7421
LPCAT1 -10615 -1283
LPCAT2 10279 8980
LPCAT3 9182 9470
LPCAT4 -3163 -6636
LPGAT1 9234 9471
LPIN1 -6615 -8764
LPIN2 -3111 -8979
LPIN3 746 -4770
LPL -4695 5136
LRP1 8118 10314
LRP10 1934 5808
LRP12 1360 7900
LRP2 -392 6762
LRP8 -3317 8175
LRPPRC -21 -7930
LSS -9415 -8363
LTA4H 10110 10291
LTC4S -665 -3436
LYPLA1 9717 9370
LYRM4 5716 -4623
LYVE1 7916 9920
MAN2B1 6033 6605
MAN2B2 -3125 5123
MAN2C1 1556 -2705
MANBA 8844 7868
MAOA 9730 10208
MAOB 9271 8917
MAPKAPK2 -10648 4888
MARCKS -4657 -3859
MARS1 -3233 1396
MAT2A 647 -869
MAT2B 1423 -7517
MBOAT1 6004 5067
MBOAT2 9664 7323
MBOAT7 9673 8771
MBTPS1 -1835 5184
MBTPS2 1231 5741
MCAT 4954 4803
MCCC1 -2805 -1715
MCCC2 -5277 -8761
MCEE 4174 -38
MDH1 7216 3832
MDH2 5674 6208
ME1 9527 10503
ME2 9745 7547
ME3 -6761 -9043
MECR 2575 -4057
MED1 -6238 727
MED10 -828 -7417
MED11 1992 -2444
MED12 -8380 1471
MED13 -1483 4991
MED13L 6 7722
MED14 -2412 3032
MED15 -8353 -9757
MED16 7359 4691
MED17 7200 1962
MED18 -193 6966
MED19 5075 4066
MED20 6919 9143
MED21 122 -1891
MED22 -5377 1941
MED23 -6461 -3313
MED24 -9165 -2277
MED25 4306 7693
MED26 -4575 7407
MED27 -5519 -3826
MED28 1419 1141
MED29 -7150 -5307
MED30 -3213 -6485
MED31 8682 -414
MED4 8051 5518
MED6 7820 344
MED7 5411 5193
MED8 8376 8117
MED9 -7351 -4924
MFSD2A 3864 -6625
MGLL 5785 8910
MGST1 10318 10658
MGST2 9602 10104
MGST3 9392 7962
MID1IP1 987 -4253
MIGA1 -1607 -6785
MIGA2 -6495 -6802
MINPP1 531 3217
MIOX 1152 -854
MLX 7872 9857
MLXIPL 6525 8370
MLYCD -8511 -8106
MMAA -4030 -6839
MMAB -4078 -4012
MMACHC -1466 -4890
MMADHC 8041 6677
MMS19 -7046 -2750
MMUT 8024 6667
MOCOS 6681 4748
MOCS1 -9933 -4004
MOCS2 4142 -5884
MOCS3 -8789 -5306
MOGAT3 -2321 2379
MORC2 -1368 -7797
MPC1 8067 1435
MPC2 6843 4288
MPST 3823 8441
MRI1 -3426 -5023
MSMO1 6953 4919
MT-ATP6 -5000 3338
MT-ATP8 -8176 7306
MT-CO1 2995 5163
MT-CO2 2723 3643
MT-CO3 307 4978
MT-CYB -2505 365
MT-ND1 -3359 -920
MT-ND2 -6325 -4137
MT-ND3 886 1784
MT-ND4 641 3660
MT-ND5 -2601 2772
MT-ND6 6472 6305
MTAP 3682 642
MTF1 10000 9766
MTHFD1 116 -10138
MTHFD1L 6678 2712
MTHFD2 9857 9780
MTHFD2L 4503 3776
MTHFR 1249 6156
MTHFS 9180 9270
MTM1 9469 6434
MTMR1 -7482 -1234
MTMR10 8020 8731
MTMR12 -6532 2399
MTMR14 8458 9446
MTMR2 -4534 489
MTMR3 8633 10212
MTMR4 -6891 4594
MTMR6 9243 8582
MTMR7 3296 791
MTMR8 -9426 -6035
MTMR9 671 5127
MTR -10199 -10364
MTRR 2273 4990
MVD -7748 -625
MVK -10315 -4217
N6AMT1 -6775 -9870
NAALAD2 3284 -4323
NADK 8612 7438
NADK2 -2629 -1357
NADSYN1 -1397 1684
NAGLU -8909 -1343
NAGS 1165 5587
NAMPT 7122 7727
NAPRT 6733 8768
NAT1 9149 6865
NAT8L -10304 -8465
NAXD -1992 -5550
NAXE 1410 -1834
NCOA1 -3324 5089
NCOA2 -7260 1011
NCOA3 -2432 5828
NCOA6 -5126 8092
NCOR1 -1531 9348
NCOR2 -2998 10117
NDC1 -8939 -10351
NDOR1 -1122 1335
NDST1 7965 9402
NDST2 7833 8514
NDUFA1 5265 7768
NDUFA10 -5642 -1013
NDUFA11 4155 -1362
NDUFA12 6496 3034
NDUFA13 2094 5390
NDUFA2 3139 5257
NDUFA3 1012 2616
NDUFA4 8573 9057
NDUFA5 4399 -1289
NDUFA6 3765 6106
NDUFA7 7692 7856
NDUFA8 8951 4747
NDUFA9 954 -153
NDUFAB1 9435 5334
NDUFAF1 8656 8639
NDUFAF2 4249 5603
NDUFAF3 4509 6763
NDUFAF4 -2041 -9027
NDUFAF5 -4385 -3905
NDUFAF6 2220 2420
NDUFAF7 -2530 5726
NDUFB1 7433 10164
NDUFB10 6206 6495
NDUFB11 -293 -282
NDUFB2 -3647 -4166
NDUFB3 9075 9321
NDUFB4 6520 6110
NDUFB5 8646 6075
NDUFB6 5249 4452
NDUFB7 2963 1058
NDUFB8 752 3261
NDUFB9 9167 9565
NDUFC1 7046 8373
NDUFC2 7348 9008
NDUFS1 5479 9340
NDUFS2 4737 7929
NDUFS3 1276 2496
NDUFS4 8342 4293
NDUFS5 4941 7336
NDUFS6 4032 6868
NDUFS7 3115 2433
NDUFS8 3125 -1053
NDUFV1 -7714 -8421
NDUFV2 9236 7085
NDUFV3 8152 7579
NEU1 9609 10026
NEU3 -5831 -3117
NFS1 8146 9047
NFYA -2090 1602
NFYB -88 -9577
NFYC 7025 8726
NHLRC1 -7039 -618
NME1 5083 2509
NME2 5550 1269
NME3 193 -2244
NME4 5915 6569
NMNAT1 9446 10561
NMNAT2 9918 10663
NMNAT3 -5361 -407
NMRAL1 -9397 -4078
NMRK1 -2228 -5419
NNT -2982 8223
NOS3 7751 -4608
NOSIP 5015 -8052
NPAS2 2505 -49
NQO1 2455 -2338
NQO2 8942 8630
NR1D1 1986 -8359
NR1H2 4953 7742
NR1H3 -3942 -2012
NRF1 -9882 -5101
NSDHL 5988 5904
NT5C -9734 -5895
NT5C1B -3551 -7721
NT5C2 9623 9466
NT5C3A 3318 1586
NT5E -7266 -9054
NT5M 1772 5041
NUBP1 6026 6349
NUBP2 -6848 -8290
NUBPL -6298 -8977
NUDT1 -1058 2196
NUDT11 -10491 -5988
NUDT12 6757 -2055
NUDT13 2921 -795
NUDT15 9274 -3708
NUDT16 9089 10586
NUDT18 -3975 1811
NUDT19 3945 8338
NUDT3 5253 7595
NUDT4 6208 7514
NUDT5 343 290
NUDT7 621 -161
NUDT9 7993 8520
NUP107 -8816 -8274
NUP133 -5348 776
NUP153 -6945 -3734
NUP155 -5317 -7756
NUP160 -2219 -8347
NUP188 -9248 -9221
NUP205 -7213 -7389
NUP210 -10535 -6252
NUP214 8257 8111
NUP35 -4124 -8851
NUP37 5728 6078
NUP42 2461 -1423
NUP43 -3773 -8208
NUP50 6620 2938
NUP54 6985 -5266
NUP58 9614 9817
NUP62 6407 -2545
NUP85 2286 -2781
NUP88 -8115 -8802
NUP93 -5242 -7982
NUP98 -1200 2149
OAT 9923 9712
OAZ1 9594 10002
OAZ2 9736 9701
OAZ3 1748 -2794
OCRL 6438 9145
ODC1 14 2523
OGDH -2787 5155
OPLAH 10311 10231
ORMDL1 -3006 926
ORMDL2 7325 7321
ORMDL3 -10039 -8440
OSBP -4175 1633
OSBPL10 -4552 -204
OSBPL1A -7050 -8293
OSBPL2 -10034 3650
OSBPL3 -10063 -10304
OSBPL5 -10926 -10167
OSBPL6 5552 -1949
OSBPL7 -9130 -9284
OSBPL8 8630 6591
OSBPL9 6745 6806
OXCT1 -6197 -9522
OXCT2 145 -6381
PAICS 8703 -6208
PANK1 2311 3106
PANK2 7922 6555
PANK3 3586 4975
PANK4 -8948 -5998
PAOX -9599 -9042
PAPSS1 9496 10017
PAPSS2 -10395 3684
PARP10 -8017 -9107
PARP14 -7760 -10413
PARP16 -10098 -10629
PARP4 -357 8142
PARP6 -3190 -1716
PARP8 -5883 -9490
PARP9 6037 -5670
PC 8077 10378
PCBD1 7684 9728
PCCA -5364 -5495
PCCB -8367 -5614
PCK2 -474 1542
PCTP 10228 10119
PCYT1A 5243 7254
PCYT1B 2035 9155
PCYT2 -9500 -8878
PDHA1 1603 3183
PDHB 8732 5499
PDHX 9405 5798
PDK1 7585 1755
PDK2 -8421 -6309
PDK3 -3793 2930
PDK4 6383 8816
PDP1 -902 -7047
PDP2 -8253 -10235
PDPR -9292 -2942
PDSS1 9497 8976
PDSS2 7997 8443
PDXK 9531 9355
PDZD11 -3651 -3584
PECR 8882 9503
PEMT 7879 -1580
PEX11A -9705 958
PFAS -9312 -9384
PFKFB1 -4583 -4058
PFKFB2 -8259 8216
PFKFB3 8640 9200
PFKFB4 9625 10205
PFKL -4628 -3901
PFKM 3054 1243
PFKP -9257 1847
PGAM1 10347 10422
PGD 10324 10568
PGK1 10177 9226
PGLS 3944 5885
PGM1 2601 6092
PGM2 10212 10292
PGM2L1 -2538 4458
PGP -7267 -4562
PGS1 8806 9233
PHGDH 298 -721
PHKA2 3539 9674
PHKB 9028 10385
PHKG1 -1054 -7152
PHKG2 -1624 1222
PHOSPHO1 -6085 -4415
PHYH 5084 -674
PHYKPL 5592 8137
PI4K2A -10071 170
PI4K2B -1306 -9965
PI4KA -7281 -1853
PI4KB -5384 -3857
PIAS4 -2221 7565
PIK3C2A 99 -876
PIK3C2B -10282 -10321
PIK3C2G -1717 -828
PIK3C3 4588 3248
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3CD -932 3422
PIK3CG -9133 3842
PIK3R1 -7314 -9108
PIK3R2 2369 6022
PIK3R3 -10971 -7175
PIK3R4 -624 -83
PIK3R5 -10408 -5867
PIK3R6 6288 8699
PIKFYVE -122 5199
PIP4K2A -8550 3142
PIP4K2B -7834 -2440
PIP4K2C -10333 -5556
PIP5K1A 7643 7381
PIP5K1B 3569 6574
PIP5K1C -4414 4334
PIPOX -9513 -8008
PISD 8987 10281
PITPNB 3137 -1255
PITPNM1 -5993 6953
PITPNM2 -9116 2634
PITPNM3 -1512 2279
PKM 10317 10280
PLA2G10 -632 -4935
PLA2G12A 4168 4597
PLA2G15 7645 10382
PLA2G2D -143 2911
PLA2G4A 10226 10618
PLA2G4B 1435 -6178
PLA2G4C -7987 17
PLA2G4D -5097 4824
PLA2G6 -10438 -10350
PLA2R1 3499 7129
PLAAT1 2747 3326
PLAAT2 5182 -5374
PLAAT3 -9871 -7641
PLAAT4 -10146 -10689
PLB1 10170 10628
PLBD1 10356 10674
PLCB1 -5094 -886
PLCB2 3198 5575
PLCB3 8119 10471
PLCD1 -4834 -7631
PLCD3 9669 10419
PLCD4 -410 -10226
PLCE1 -2489 -2687
PLCG1 -5836 -10187
PLCG2 -6227 6708
PLCH1 -1684 2977
PLCH2 -9387 -9994
PLD1 10119 10572
PLD2 6138 9091
PLD3 8046 6488
PLD4 -11002 -10493
PLD6 5755 -5697
PLEKHA1 -10527 -10395
PLEKHA2 -7524 1744
PLEKHA3 -3081 565
PLEKHA4 -4482 589
PLEKHA5 -6000 -4521
PLEKHA6 -2744 -4606
PLEKHA8 -2105 -1934
PLIN1 -6520 3635
PLIN2 6236 10259
PLIN3 10168 10515
PLPP1 7609 -7962
PLPP2 5848 3305
PLPP3 3344 9714
PLPP6 -8764 -5841
PM20D1 -7373 -9620
PMVK 5102 4922
PNMT -5933 -2105
PNP 9592 9563
PNPLA2 9549 9963
PNPLA4 2831 -44
PNPLA6 -3444 8208
PNPLA7 -3337 -6703
PNPLA8 9191 8945
PNPO -5851 -5642
PODXL2 -8991 -4255
POLD1 -1902 214
POM121 -9318 -4714
POM121C -10088 -6969
POMC 2426 -2728
PON2 -3370 879
POR 6474 9435
PPA1 9593 -2306
PPA2 6902 5273
PPARA -7992 2961
PPARD -2980 -6109
PPARG 10358 10670
PPARGC1A 5105 6389
PPARGC1B -2932 -2066
PPAT -2103 -9864
PPCDC -5738 -5230
PPCS 8900 5684
PPIP5K1 -9052 -6666
PPIP5K2 8214 9065
PPM1K -9086 -9483
PPM1L -9905 4684
PPOX -8921 -8360
PPP1CA 1299 5236
PPP1CB 8424 7913
PPP1CC 9534 8032
PPP2CA 9766 8577
PPP2CB 9136 9093
PPP2R1A 1997 5379
PPP2R1B 3691 1706
PPP2R5D -5620 3209
PPT1 10321 9873
PPT2 -9994 -9068
PRELP 3410 1496
PRKAB2 -6078 -3690
PRKACA 9995 10558
PRKACB -8479 -10448
PRKAG2 7267 1382
PRKAR1A 8904 9754
PRKAR1B 7778 8646
PRKAR2A 1151 7558
PRKAR2B 4069 6461
PRKCA 2691 1966
PRKD2 -8779 -7038
PRKD3 2093 6620
PRKG2 -7286 -6385
PRODH -5621 -8267
PRPS1 -9525 -10253
PRPS2 9598 3319
PRSS1 -9682 -4994
PRXL2B 835 -8833
PSAP 8066 8239
PSAT1 9086 8094
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
PSPH 4886 7582
PSTK -7923 -5193
PTDSS1 9364 6940
PTDSS2 5420 3726
PTEN 8668 9329
PTGDS -10042 -5523
PTGES -7502 2537
PTGES2 -4699 -4573
PTGES3 9517 4303
PTGR1 9739 10613
PTGR2 5321 6976
PTGS1 8122 8323
PTGS2 8500 5863
PTPMT1 6451 1642
PTPN13 -7614 -7223
PTS -800 -7382
PUDP 10188 8408
PXMP2 -977 6753
PYCR1 9061 6447
PYCR2 -7844 -1941
PYGB -6473 454
PYGL 10308 10199
PYGM -5027 -9251
QARS1 -1631 800
QDPR 609 -4469
QPRT -10738 -9250
RAB14 8765 8436
RAB4A 8673 6735
RAB5A 9230 7808
RAE1 7170 7531
RAN 4957 -2873
RANBP2 457 512
RAP1A 9691 8186
RAPGEF3 -5747 5214
RARS1 6167 2457
RBKS -7371 326
RDH11 3639 6991
RETSAT -2295 -1561
RFK 8617 3043
RGL1 9370 9936
RHCE 7059 4008
RHD 6933 -1171
RIDA 7910 6851
RIMKLA 637 -1628
RIMKLB -8277 -8736
RNLS 5309 7017
RORA -10427 -10611
RPE -444 8383
RPIA 5489 -714
RPL10 631 -5696
RPL10A 1976 -6292
RPL11 1839 -3327
RPL12 2014 -5298
RPL13 2796 -3228
RPL13A -1728 -6706
RPL14 -1317 -5766
RPL15 5748 532
RPL17 143 -3476
RPL18 3381 -4456
RPL18A -1706 -4694
RPL19 -787 -4539
RPL21 276 -3918
RPL22 4761 -1687
RPL22L1 7231 -349
RPL23 3153 -1612
RPL23A -903 -7885
RPL24 1656 -1751
RPL26 842 -3483
RPL26L1 8258 7992
RPL27 1376 -417
RPL27A -1685 -3049
RPL28 2709 -1855
RPL29 1515 -3475
RPL3 -3958 -7454
RPL30 -2576 -5578
RPL31 -429 -3242
RPL32 219 -4702
RPL34 -1732 -6642
RPL35 -9119 -4134
RPL35A -112 -2513
RPL36 -4022 -4235
RPL36A 1606 -4363
RPL36AL 5944 -2052
RPL37 -6271 -3029
RPL37A -2362 -447
RPL38 -4515 -3500
RPL39 2137 350
RPL39L -7572 -3974
RPL4 4738 -2403
RPL41 -1299 -3511
RPL5 4105 -2796
RPL6 4935 -1237
RPL7 5143 -1272
RPL7A 1809 -1927
RPL8 1265 -1924
RPL9 700 -4879
RPLP0 6333 -1009
RPLP1 -1197 916
RPLP2 -4847 -5802
RPS10 -489 -4974
RPS11 -2316 -5641
RPS12 -4797 -7620
RPS13 5276 -1635
RPS14 -4624 -5393
RPS15 -1754 -3299
RPS15A 1269 -4048
RPS16 -2078 -6063
RPS17 -5045 -3169
RPS18 -7322 -6605
RPS19 -2989 -7057
RPS2 1634 -3308
RPS20 -2911 -6018
RPS21 -1933 -3896
RPS23 772 -4150
RPS24 6586 1001
RPS25 2600 -3817
RPS26 3527 -5041
RPS27 -7168 -6878
RPS27A -1868 -5386
RPS27L 7604 4230
RPS28 -2921 -3626
RPS29 -6817 -4617
RPS3 2486 -5123
RPS3A 5865 -3619
RPS4X -677 -7632
RPS4Y1 3815 574
RPS5 -1017 -5500
RPS6 2176 -3737
RPS7 1946 -2271
RPS8 3760 -769
RPS9 7673 4928
RPSA -3597 -5016
RRM1 49 -9871
RRM2 4568 -3915
RRM2B 8011 7499
RTEL1 -8144 2309
RUFY1 2628 6507
RXRA 6389 8760
RXRB -2481 479
SACM1L -6759 -5024
SAMD8 7895 8227
SAMHD1 8475 7578
SAR1B 9412 8914
SARDH -5162 -9223
SARS1 496 -3575
SAT1 5061 6413
SBF1 -10005 -8548
SBF2 9786 10402
SC5D 5204 -227
SCAP -7316 -7643
SCD 4702 3606
SCD5 -10439 -2366
SCLY -4995 -7469
SCO1 -560 -5166
SCO2 5178 -9665
SCP2 7718 6645
SDC2 6034 5778
SDC3 8050 -2699
SDC4 7546 7624
SDHA -7420 -4414
SDHB 7368 9153
SDHC 9342 9775
SDHD 9801 7526
SDS -6737 -2204
SDSL -1733 4392
SEC13 6324 5321
SEC23A 8250 8136
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SECISBP2 -2529 -9656
SEH1L 8372 -4799
SELENOI -2536 -8997
SEM1 5210 6938
SEPHS2 8821 8013
SEPSECS -6690 -9390
SERINC1 6100 5870
SERINC2 8085 10189
SERINC3 1705 8104
SERINC4 4363 -1254
SERINC5 1223 -6858
SGMS1 8975 10145
SGMS2 9770 10581
SGPL1 -7740 7182
SGPP1 -10860 -8813
SGPP2 -2498 -6353
SGSH 4711 5490
SHMT1 -6047 655
SHMT2 -7819 1853
SHPK -4639 -1540
SIN3A -8565 -8326
SIN3B -5683 -6222
SLC10A1 -547 -1978
SLC16A1 5760 3184
SLC16A3 8534 9884
SLC16A8 -9216 6532
SLC19A1 9059 9484
SLC19A2 -7721 1717
SLC19A3 -6769 2249
SLC22A1 -3791 4811
SLC22A5 8103 9235
SLC23A1 1317 459
SLC23A2 -7603 2729
SLC25A1 4097 6169
SLC25A10 -9794 -8478
SLC25A11 3729 7786
SLC25A12 -740 3470
SLC25A13 2734 6506
SLC25A14 -1042 -2588
SLC25A15 -9206 -5609
SLC25A16 5586 4054
SLC25A17 2344 -4434
SLC25A19 6433 -627
SLC25A20 -3354 6571
SLC25A21 7462 752
SLC25A27 3773 -6502
SLC25A28 4213 -934
SLC25A32 4856 -8661
SLC25A37 10285 9870
SLC25A44 7449 6729
SLC26A1 -6617 -7798
SLC26A2 -4754 3163
SLC27A1 8348 8149
SLC27A2 8033 -6002
SLC27A3 -2658 -2290
SLC27A5 -2143 568
SLC2A1 -10701 -8961
SLC2A3 10169 9727
SLC35B2 -7930 -5440
SLC35B3 8568 7215
SLC35D1 -9609 -1243
SLC35D2 6867 7970
SLC36A4 7925 9685
SLC37A1 -2655 -2654
SLC37A2 3171 1263
SLC37A4 -7007 -3274
SLC3A2 3731 6261
SLC44A1 8910 9654
SLC44A2 -3421 2167
SLC44A5 4109 -573
SLC46A1 -6011 -57
SLC52A1 6053 -6158
SLC52A2 -7755 -6188
SLC5A5 4332 -7342
SLC5A6 -3378 -4394
SLC6A12 8892 680
SLC6A8 9455 9029
SLC7A5 3880 2996
SLC9A1 1175 9205
SLCO2B1 7490 9554
SMARCD3 10015 8573
SMOX -2195 7529
SMPD1 -9521 2160
SMPD2 -4755 5874
SMPD3 -10029 -9933
SMPD4 -9407 -7697
SMS 9006 4129
SORD 8678 9655
SP1 6728 9578
SPHK1 8695 8421
SPHK2 -6162 4445
SPNS2 6156 4825
SPR 6863 7749
SPTLC1 9600 10012
SPTLC2 8663 10151
SPTLC3 6204 2354
SPTSSA 8052 -50
SPTSSB -10212 -3415
SQLE 2769 8138
SRD5A1 9060 8926
SRD5A3 7881 1403
SREBF1 8706 1961
SREBF2 4892 8248
SRM 5803 -8110
SRR 5669 -800
ST3GAL1 -7981 -6569
ST3GAL2 7602 9502
ST3GAL3 -1028 2393
ST3GAL4 -9447 4972
ST3GAL6 9322 5613
ST6GALNAC6 -10568 -10104
STAB2 6753 7249
STAR -1085 -1594
STARD10 6043 -2723
STARD3 -6350 4096
STARD3NL 7975 8944
STARD4 -2521 -789
STARD5 -9504 985
STARD7 4649 6076
STK11 888 -956
STS 176 5094
STX1A -8692 -2626
STXBP1 4554 -10013
SUCLA2 9774 8374
SUCLG1 7304 5981
SUCLG2 3705 -4033
SULT1A1 9813 8719
SULT1A2 -1961 -7913
SULT1A3 6754 3320
SULT1A4 8531 8484
SULT1B1 10078 10570
SULT1C2 -4994 3568
SULT2B1 212 -7216
SUMF1 9836 10078
SUMF2 -10639 -7655
SUMO2 8206 6024
SUOX -2973 9228
SURF1 5404 1530
SYNJ1 1280 7746
SYNJ2 -6719 -7296
SYT5 2034 6175
TACO1 4959 5943
TALDO1 10319 10395
TAZ 4315 4951
TBL1X 6931 7717
TBL1XR1 5299 5430
TBXAS1 8240 10114
TCN1 9143 3640
TCN2 9870 9929
TECR -4076 -7329
TECRL -5434 1478
TGS1 410 -2742
THEM4 -1580 -10466
THEM5 -1662 -9783
THRAP3 -4430 3845
THTPA -7596 -2086
TIAM2 -9556 -9322
TIMMDC1 8385 8473
TK1 4360 4041
TK2 9450 10535
TKFC 6312 5992
TKT 9929 10560
TM7SF2 -3634 -5918
TMEM126B -221 -3886
TMEM86B 4861 828
TMLHE 2536 8978
TNFAIP8 4030 1508
TNFAIP8L1 -9678 -7149
TNFAIP8L2 8056 2927
TNFRSF21 -10898 -4962
TPH1 4060 -6005
TPH2 -807 6631
TPI1 8124 7502
TPK1 1586 1807
TPMT 7839 6563
TPO 7768 774
TPR -4478 -7012
TPST1 2152 10253
TPST2 -8642 6809
TRAP1 -4626 -9571
TRIB3 -7114 -4878
TRMT112 3035 510
TSPO 10124 10235
TSPOAP1 -10588 -9052
TST 6936 6810
TSTD1 -6253 -7470
TTPA -1962 5802
TXN 9660 8103
TXN2 7093 6979
TXNRD1 8785 8833
TYMP 7513 -178
TYMS 7496 -2060
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UBE2I -1027 5239
UBIAD1 -4512 -10269
UCK1 -905 5906
UCK2 -8725 -16
UCKL1 547 -4888
UCP2 -3241 4728
UCP3 -6187 -7539
UGCG 5761 5972
UGDH 1631 6776
UGP2 9539 7983
UGT1A1 -4863 2251
UGT2B11 -7372 -9526
UGT8 -6633 440
UMPS -1722 -8876
UPB1 6168 4686
UPP1 9863 9147
UQCR10 3747 6293
UQCR11 8377 8061
UQCRB 6557 5036
UQCRC1 8264 8723
UQCRC2 9566 6489
UQCRFS1 7740 7015
UQCRH 8075 8773
UQCRQ 4092 3891
UROD 4633 5866
UROS -4734 -6794
UST -10627 -10344
VAC14 -4428 4493
VAMP2 -4429 -10264
VAPA 9859 9626
VAPB 5006 4743
VCAN 10280 10667
VDAC1 7258 5858
VDR 5697 10052
VKORC1 6942 6053
VKORC1L1 4396 7853
VNN1 10163 10414
VNN2 9682 9921
WASL -3272 1473
XYLB -7368 -8319
XYLT1 -10519 2988
XYLT2 -8070 -3098
ZDHHC21 -2854 -3157



Metabolism of proteins

Metabolism of proteins
metric value
setSize 1706
pMANOVA 2.4e-31
p.adjustMANOVA 5.44e-29
s.dist 0.216
s.low.CRP 0.164
s.high.CRP 0.141
p.low.CRP 1.35e-29
p.high.CRP 3.77e-22




Top 20 genes
Gene low CRP high CRP
CSF2RA 10368 10661
PPARG 10358 10670
FAM20A 10342 10679
ADAMTS2 10314 10665
SOCS3 10312 10656
CTSA 10310 10636
VCAN 10280 10667
F5 10339 10599
NPL 10251 10671
FBXO9 10306 10429
RAB13 10172 10518
BST1 10348 10335
XRN2 10201 10472
RHOT1 10236 10427
ASGR2 9976 10675
CTSD 9997 10635
VNN1 10163 10414
GNG10 10307 10252
FAM20C 10013 10541
KIF13A 9898 10660

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAAS -4220.0 -2848.0
AARS1 -407.0 -5945.0
AARS2 -9558.0 -8848.0
ABCA3 -10372.0 -9956.0
ACADVL 9301.0 9478.0
ACE 8131.0 -10036.0
ACTB 10142.0 9915.0
ACTL6A 644.0 -1140.0
ACTR10 9447.0 8995.0
ACTR1A 1291.0 7735.0
ACTR5 -8300.0 -8488.0
ACTR8 -9028.0 1290.0
ADAM10 9652.0 10284.0
ADAMTS1 -10925.0 -6738.0
ADAMTS10 -10554.0 -9120.0
ADAMTS13 -717.0 -2609.0
ADAMTS14 -9572.0 -7264.0
ADAMTS16 -5486.0 -6100.0
ADAMTS17 1716.0 -5751.0
ADAMTS2 10314.0 10665.0
ADAMTS4 -9692.0 -8176.0
ADAMTS5 1277.0 -7082.0
ADAMTS6 -8817.0 -299.0
ADAMTSL3 -1249.0 -436.0
ADAMTSL4 8696.0 8969.0
ADAMTSL5 1742.0 -9869.0
ADD1 -6996.0 7592.0
ADORA2A -1381.0 -1440.0
ADORA2B 6712.0 10334.0
ADRA2A -4933.0 4150.0
ADRB2 -10762.0 -9843.0
ADRM1 338.0 3615.0
AGBL2 -7394.0 -7194.0
AGBL3 -2844.0 -8651.0
AGBL5 3831.0 3775.0
AGTPBP1 9472.0 9538.0
AIMP1 7312.0 -5118.0
AIMP2 6547.0 729.0
ALB 5157.0 1598.0
ALG1 -7518.0 -4565.0
ALG10 -9295.0 -2926.0
ALG10B 2640.0 -6554.0
ALG11 -4114.0 415.0
ALG12 -1788.0 -1158.0
ALG13 1354.0 -7430.0
ALG14 9158.0 8578.0
ALG2 6463.0 2704.0
ALG3 5995.0 -2482.0
ALG5 7403.0 2248.0
ALG6 7443.0 7333.0
ALG8 7380.0 705.0
ALG9 -3668.0 -3824.0
ALPL 8001.0 9349.0
AMDHD2 -10379.0 -9214.0
AMFR 9169.0 6554.0
ANK1 9056.0 9344.0
ANK3 5423.0 -4595.0
ANKRD28 -8321.0 -2586.0
ANKRD9 4178.0 7756.0
ANO8 3927.0 6336.0
ANPEP 10206.0 10073.0
AOPEP -425.0 9505.0
AP3M1 8097.0 7466.0
APC -2802.0 3982.0
APEH -6699.0 1881.0
APH1A 3292.0 4183.0
APH1B 5962.0 8800.0
APLP2 9754.0 10588.0
APOA2 7224.0 7075.0
APOE -4921.0 3265.0
APOL1 1106.0 -9021.0
APP 10085.0 9961.0
AR -1905.0 4565.0
ARCN1 4291.0 7676.0
AREG -5505.0 9162.0
ARF1 9085.0 10196.0
ARF3 7124.0 9257.0
ARF4 10147.0 10254.0
ARF5 8080.0 9476.0
ARFGAP1 -2066.0 -296.0
ARFGAP2 -7117.0 -3644.0
ARFGAP3 2322.0 4136.0
ARFGEF2 -6269.0 1850.0
ARL2 3396.0 3132.0
ARRB1 -5720.0 3058.0
ARRB2 8232.0 9058.0
ARSA 6282.0 1069.0
ARSB 8290.0 9046.0
ARSD 7388.0 8269.0
ARSG -4.0 -7971.0
ARSJ -5813.0 -6407.0
ARSK -7489.0 -9464.0
ASB1 -7836.0 6220.0
ASB13 1661.0 1645.0
ASB14 762.0 662.0
ASB16 -4955.0 -2085.0
ASB2 -10383.0 -9299.0
ASB3 5783.0 4906.0
ASB4 -5402.0 -5291.0
ASB6 -7850.0 -4746.0
ASB7 5499.0 6321.0
ASB8 2931.0 5919.0
ASB9 1599.0 714.0
ASGR1 10213.0 10074.0
ASGR2 9976.0 10675.0
ASNS 3189.0 -6265.0
ASXL1 -6154.0 -8199.0
ASXL2 -4942.0 4265.0
ATF3 -6766.0 -10451.0
ATF4 8523.0 6223.0
ATF6 8971.0 9535.0
ATP6AP2 9781.0 8803.0
ATP6V0D1 10069.0 10341.0
ATXN3 5363.0 2787.0
ATXN7 5967.0 -2684.0
AURKA 3460.0 4836.0
AURKAIP1 4008.0 3839.0
AURKB 720.0 709.0
AXIN1 -10501.0 -8999.0
AXIN2 2553.0 -7267.0
B2M 58.0 -7420.0
B3GALNT2 4426.0 1998.0
B3GLCT -10293.0 -8087.0
B3GNT2 6491.0 4534.0
B3GNT4 -3531.0 -9653.0
B3GNT5 10268.0 8681.0
B3GNT7 -10766.0 -10193.0
B3GNT8 9784.0 9012.0
B3GNT9 5206.0 -9789.0
B3GNTL1 5069.0 5996.0
B4GALNT2 -4045.0 2852.0
B4GALT1 -3872.0 6820.0
B4GALT2 -2272.0 31.0
B4GALT3 -7395.0 -8398.0
B4GALT4 -6517.0 3566.0
B4GALT5 9525.0 9637.0
B4GALT6 -10803.0 131.0
B4GAT1 -1787.0 -2379.0
BABAM1 -493.0 1445.0
BACE1 2751.0 -1935.0
BAP1 -8951.0 1556.0
BARD1 -9066.0 -710.0
BCL10 6535.0 3786.0
BECN1 8030.0 6913.0
BET1 6957.0 1985.0
BET1L -4965.0 -5604.0
BGLAP 4253.0 -2208.0
BIRC2 8116.0 2944.0
BIRC3 2030.0 -10298.0
BIRC5 5078.0 5144.0
BLM 2729.0 -1602.0
BMI1 -1361.0 -6301.0
BRCA1 4641.0 7113.0
BRCC3 8635.0 8909.0
BST1 10348.0 10335.0
BTBD1 6779.0 3894.0
BTBD6 -7180.0 -3405.0
BTRC -7062.0 1812.0
C1GALT1 5940.0 -6509.0
C1GALT1C1 9935.0 9105.0
C3 -10957.0 -10571.0
C4A 6469.0 1331.0
CALB1 -2482.0 -4582.0
CALM1 -4337.0 1051.0
CALR 8310.0 6954.0
CALU 8618.0 9731.0
CAMKMT 4722.0 4211.0
CAND1 1355.0 -1576.0
CANX 7507.0 7257.0
CAPZA1 9332.0 9316.0
CAPZA2 10077.0 9039.0
CAPZB 8393.0 8843.0
CARS1 6786.0 8749.0
CARS2 8428.0 7398.0
CASP8AP2 -5179.0 -8795.0
CBX2 -8946.0 -3592.0
CBX4 -8089.0 61.0
CBX5 -5063.0 -7545.0
CBX8 2677.0 6583.0
CCDC22 3107.0 8147.0
CCDC59 4211.0 -1000.0
CCDC8 5122.0 -329.0
CCL2 -10551.0 -10635.0
CCNA1 2520.0 -2665.0
CCNA2 3177.0 2827.0
CCNE1 -6448.0 -9772.0
CCNE2 5682.0 6596.0
CCNF -9341.0 -8844.0
CCP110 3033.0 4396.0
CCT2 6166.0 -5938.0
CCT3 1236.0 229.0
CCT4 7652.0 2442.0
CCT5 9799.0 7374.0
CCT6A 5427.0 1447.0
CCT6B -4718.0 -5710.0
CCT7 3238.0 -1099.0
CCT8 9483.0 8073.0
CD109 6898.0 6560.0
CD52 -1180.0 -2842.0
CD55 9747.0 10312.0
CD59 6386.0 4199.0
CDC20 3581.0 3590.0
CDC25A 4343.0 4765.0
CDC34 7794.0 8739.0
CDC73 5260.0 6248.0
CDCA8 -1406.0 -3171.0
CDK1 7292.0 -2497.0
CDKN2A -4195.0 308.0
CEBPB 3064.0 8385.0
CEBPG 7532.0 7427.0
CES1 10326.0 9607.0
CETN2 7674.0 6463.0
CFP 8398.0 8912.0
CHCHD1 7055.0 8561.0
CHD3 -9906.0 -8152.0
CHM 3048.0 6845.0
CHML 1075.0 374.0
CHST10 -10642.0 -7986.0
CHST8 189.0 6510.0
CISH 9949.0 -655.0
CKAP4 10349.0 9973.0
CLSPN 5905.0 4810.0
CMAS 9980.0 10161.0
CNIH1 9266.0 8825.0
CNIH2 2506.0 2667.0
CNIH3 -9428.0 -8506.0
COG1 -9533.0 -9241.0
COG2 3963.0 1728.0
COG3 3114.0 -4075.0
COG4 -3232.0 889.0
COG5 3937.0 3634.0
COG6 1615.0 -87.0
COG7 7042.0 7599.0
COG8 -5751.0 -901.0
COL7A1 -442.0 8394.0
COMMD1 6830.0 6281.0
COMMD10 8997.0 5645.0
COMMD2 6747.0 6519.0
COMMD3 3550.0 2189.0
COMMD4 -4474.0 -4677.0
COMMD5 2041.0 2403.0
COMMD6 2908.0 -705.0
COMMD7 7063.0 8101.0
COMMD8 9672.0 8565.0
COMMD9 9687.0 9081.0
COPA 6851.0 10178.0
COPB1 9548.0 8670.0
COPB2 9499.0 8940.0
COPE 5686.0 8054.0
COPG1 7245.0 9390.0
COPG2 8584.0 9972.0
COPS2 9383.0 7627.0
COPS3 8156.0 5701.0
COPS4 6317.0 5948.0
COPS5 6344.0 6899.0
COPS6 889.0 3896.0
COPS7A 3083.0 7494.0
COPS7B -6235.0 -3924.0
COPS8 3385.0 -3694.0
COPZ1 8315.0 6558.0
COPZ2 -2992.0 -9775.0
CP -10052.0 1836.0
CPA3 3584.0 -9719.0
CPM 4420.0 9487.0
CREB3 -1725.0 871.0
CREB3L2 -3840.0 5182.0
CREB3L4 -10268.0 -4385.0
CREBBP -9358.0 1958.0
CREBRF 3847.0 -4811.0
CRHR2 -7686.0 823.0
CSF1 3930.0 -7629.0
CSF2RA 10368.0 10661.0
CSF2RB 9224.0 5475.0
CSNK1D -8768.0 1189.0
CSNK2A1 1926.0 9964.0
CSNK2A2 136.0 9661.0
CSNK2B 4787.0 4600.0
CST3 5014.0 -1198.0
CTBP1 -9138.0 -4408.0
CTDSP2 -1605.0 5418.0
CTNNB1 1446.0 7186.0
CTR9 2483.0 5441.0
CTSA 10310.0 10636.0
CTSC -3910.0 5638.0
CTSD 9997.0 10635.0
CTSG 9668.0 2004.0
CTSH 9551.0 7551.0
CTSZ 9796.0 10451.0
CUL1 7475.0 -10175.0
CUL2 9537.0 5772.0
CUL3 7012.0 8018.0
CUL4A 387.0 433.0
CUL4B 3280.0 5583.0
CUL5 8446.0 4656.0
CUL7 -7732.0 2154.0
CUL9 -7274.0 -3995.0
CXCL8 5888.0 -3003.0
CXXC1 1442.0 157.0
CYLD 3384.0 -10382.0
DAD1 7699.0 6258.0
DAG1 -7765.0 -3574.0
DAP3 6688.0 2267.0
DARS1 9222.0 1575.0
DARS2 -5219.0 6131.0
DAXX -9382.0 -5524.0
DCAF10 2271.0 5999.0
DCAF11 -5360.0 -62.0
DCAF13 327.0 6103.0
DCAF16 -8052.0 -8722.0
DCAF17 -8338.0 -7649.0
DCAF4 -9986.0 -9203.0
DCAF5 -10516.0 -646.0
DCAF6 7731.0 9414.0
DCAF7 -5448.0 2579.0
DCAF8 -8846.0 -5947.0
DCP2 7049.0 7228.0
DCTN1 -4701.0 7431.0
DCTN2 9097.0 10370.0
DCTN3 3675.0 7530.0
DCTN4 5909.0 10148.0
DCTN5 -6881.0 5731.0
DCTN6 9751.0 9405.0
DCUN1D1 8839.0 7457.0
DCUN1D2 1413.0 -3858.0
DCUN1D3 -3225.0 5053.0
DCUN1D4 1780.0 -8923.0
DCUN1D5 1134.0 6038.0
DDA1 -3315.0 5112.0
DDB1 442.0 7049.0
DDB2 -5550.0 -8542.0
DDIT3 2270.0 107.0
DDOST 5768.0 8734.0
DDX11 -7336.0 -4334.0
DDX17 -7364.0 -3383.0
DDX5 -9939.0 -6160.0
DDX58 -8090.0 -10356.0
DERL1 -5393.0 -6496.0
DERL2 5626.0 4860.0
DHDDS -6182.0 1919.0
DHPS 1469.0 694.0
DIS3 1689.0 -830.0
DNAJB11 7698.0 6419.0
DNAJB9 7363.0 -3450.0
DNAJC24 -1711.0 -6784.0
DNAJC3 9070.0 9215.0
DNMT1 -10299.0 -10563.0
DNMT3A -6590.0 -5560.0
DNMT3B 5329.0 6370.0
DOHH -2499.0 -3583.0
DOLK -7816.0 -482.0
DOLPP1 7664.0 3611.0
DPAGT1 6371.0 3303.0
DPH1 -7520.0 -9478.0
DPH2 -5441.0 -9209.0
DPH3 9815.0 8163.0
DPH5 3720.0 3348.0
DPH6 3336.0 -4709.0
DPH7 -7645.0 -7311.0
DPM1 5700.0 4181.0
DPM2 5599.0 2835.0
DPM3 3402.0 1010.0
DPP4 5619.0 -9028.0
DTL 3159.0 -1473.0
DYNC1H1 -9811.0 -4718.0
DYNC1I1 378.0 6338.0
DYNC1I2 8978.0 9397.0
DYNC1LI1 8227.0 7194.0
DYNC1LI2 909.0 7271.0
DYNLL1 6414.0 7208.0
DYNLL2 -5827.0 -2261.0
EARS2 -9598.0 -9423.0
EDEM1 658.0 3626.0
EDEM2 9361.0 9706.0
EDEM3 9140.0 9891.0
EEF1A1 2936.0 -4796.0
EEF1A1P5 5880.0 -3321.0
EEF1A2 -784.0 -5416.0
EEF1B2 1452.0 -2929.0
EEF1D 1598.0 -3621.0
EEF1E1 3565.0 3869.0
EEF1G 2362.0 -121.0
EEF2 -3419.0 -1260.0
EEF2KMT -998.0 -5887.0
EID3 -10366.0 -9628.0
EIF1AX 8840.0 678.0
EIF2AK3 -10001.0 -8980.0
EIF2B1 6642.0 3778.0
EIF2B2 -5594.0 5830.0
EIF2B3 1542.0 -3961.0
EIF2B4 -916.0 6165.0
EIF2B5 -3383.0 -5583.0
EIF2S1 9228.0 5747.0
EIF2S2 9166.0 7187.0
EIF2S3 7994.0 6909.0
EIF3A 2392.0 2708.0
EIF3B 1444.0 -5363.0
EIF3C -2681.0 3297.0
EIF3D 6457.0 -101.0
EIF3E 8520.0 1078.0
EIF3F 1895.0 3147.0
EIF3G 1785.0 746.0
EIF3H 8550.0 5125.0
EIF3I 8018.0 5002.0
EIF3J 8650.0 3134.0
EIF3K 4950.0 1772.0
EIF3L 6453.0 2490.0
EIF3M 9649.0 3612.0
EIF4A1 9825.0 8652.0
EIF4A2 -4531.0 -9693.0
EIF4B 2213.0 1367.0
EIF4E 8016.0 7576.0
EIF4EBP1 6719.0 6918.0
EIF4G1 5724.0 10120.0
EIF4H 7558.0 9107.0
EIF5 1261.0 4191.0
EIF5A 7900.0 -1625.0
EIF5A2 -9744.0 -9831.0
EIF5B 5000.0 -2620.0
ELOB 7369.0 8033.0
ELOC 7870.0 9351.0
ENAM -5271.0 3880.0
ENGASE -7259.0 -6058.0
EP300 -2315.0 7280.0
EPAS1 191.0 9357.0
EPRS1 3916.0 1660.0
ERAL1 994.0 238.0
ERCC8 2267.0 6718.0
ERN1 -9477.0 -8138.0
ERO1A 10293.0 8674.0
ERO1B -5803.0 -10065.0
ESR1 -6841.0 -8227.0
ETF1 9199.0 8093.0
ETFB 9144.0 9286.0
ETFBKMT 5323.0 5415.0
EXOC1 9024.0 8457.0
EXOC2 -9.0 -5242.0
EXOC3 472.0 5375.0
EXOC4 3395.0 8923.0
EXOC5 7313.0 6215.0
EXOC6 10067.0 9636.0
EXOC7 -4909.0 6670.0
EXOC8 -6622.0 -999.0
EXOSC1 2885.0 304.0
EXOSC2 -3961.0 -8955.0
EXOSC3 1418.0 2162.0
EXOSC4 5868.0 7957.0
EXOSC5 1739.0 -8095.0
EXOSC6 -9351.0 -7944.0
EXOSC7 -6315.0 -5278.0
EXOSC8 -3547.0 -9913.0
EXOSC9 2761.0 -7072.0
EXTL2 -10185.0 -8076.0
EXTL3 -6326.0 8508.0
F5 10339.0 10599.0
F8 7904.0 8494.0
FAM20A 10342.0 10679.0
FAM20C 10013.0 10541.0
FARS2 2802.0 -5254.0
FARSA -1094.0 3471.0
FARSB 6124.0 -2074.0
FAU -1127.0 -1637.0
FBN1 2956.0 6602.0
FBXL12 -1698.0 -3377.0
FBXL13 -1382.0 3518.0
FBXL14 -8163.0 -6300.0
FBXL15 3436.0 2720.0
FBXL16 5507.0 -10081.0
FBXL18 -5099.0 5653.0
FBXL19 5732.0 10057.0
FBXL20 1765.0 3859.0
FBXL22 -9153.0 -6742.0
FBXL3 1966.0 670.0
FBXL4 4486.0 8310.0
FBXL5 10325.0 10075.0
FBXL8 7525.0 1281.0
FBXO10 -9379.0 306.0
FBXO11 7621.0 8299.0
FBXO15 230.0 1947.0
FBXO17 5781.0 1662.0
FBXO2 -9215.0 -4852.0
FBXO21 -8838.0 -6075.0
FBXO22 4944.0 -234.0
FBXO27 -8323.0 -1437.0
FBXO30 2042.0 4025.0
FBXO31 -10125.0 -10514.0
FBXO32 -9370.0 -9624.0
FBXO4 -4427.0 -9673.0
FBXO40 -1666.0 3411.0
FBXO41 -7713.0 3597.0
FBXO44 -2312.0 -7442.0
FBXO6 685.0 -1568.0
FBXO7 9204.0 6315.0
FBXO9 10306.0 10429.0
FBXW11 3233.0 8725.0
FBXW12 -8674.0 -7228.0
FBXW2 -2414.0 9274.0
FBXW4 -8829.0 -9797.0
FBXW5 -8630.0 250.0
FBXW7 -8232.0 -6782.0
FBXW8 -9913.0 -6070.0
FBXW9 -8279.0 -4295.0
FCGR3B 5213.0 -2356.0
FCSK 938.0 372.0
FEM1A -6470.0 -2915.0
FEM1B 5603.0 6132.0
FEM1C 6244.0 3279.0
FFAR4 1116.0 1304.0
FGF23 1297.0 -7622.0
FKBP14 2249.0 -2782.0
FKBP8 9479.0 7120.0
FKBP9 6665.0 9756.0
FN1 9912.0 6648.0
FN3K 8138.0 1514.0
FN3KRP -3429.0 -8784.0
FOLR2 8927.0 -10004.0
FOXK1 -7937.0 -4184.0
FOXK2 -7008.0 5189.0
FOXO4 -2621.0 6949.0
FPGT 8920.0 7632.0
FSTL1 8734.0 8947.0
FSTL3 9917.0 10500.0
FUCA1 9326.0 10044.0
FUCA2 9523.0 9365.0
FUOM 2246.0 -6791.0
FURIN 7688.0 10324.0
FUT8 -9860.0 -5220.0
GADD45GIP1 2005.0 378.0
GALNT1 7857.0 7854.0
GALNT10 -10083.0 -731.0
GALNT11 -128.0 1173.0
GALNT12 -6226.0 -8838.0
GALNT14 8809.0 8984.0
GALNT15 -7591.0 249.0
GALNT16 -1377.0 4947.0
GALNT2 7832.0 9935.0
GALNT3 -5321.0 762.0
GALNT4 3872.0 7513.0
GALNT5 -3789.0 945.0
GALNT6 3621.0 -2373.0
GALNT7 8255.0 10237.0
GALNT8 2200.0 -9940.0
GALNT9 -2006.0 -10345.0
GAN -7017.0 -911.0
GANAB -7302.0 2200.0
GARS1 9748.0 9166.0
GAS6 9599.0 9997.0
GATA3 -8401.0 -10666.0
GATA6 -10749.0 -8672.0
GBA 9467.0 9882.0
GBF1 -8195.0 348.0
GCNT1 8047.0 9868.0
GCNT3 8783.0 6468.0
GCNT4 53.0 -10714.0
GCNT7 -5413.0 4295.0
GFM1 4888.0 -3769.0
GFM2 7651.0 5825.0
GFPT1 -648.0 -5626.0
GFPT2 -10443.0 -7593.0
GGA1 -461.0 6124.0
GGA2 -10705.0 -503.0
GGA3 564.0 5909.0
GGCX -4196.0 7376.0
GHRL -6168.0 -9863.0
GLB1 9395.0 10125.0
GMDS 6596.0 6467.0
GMPPA 5689.0 5696.0
GMPPB -2532.0 -5077.0
GNAI1 5305.0 5103.0
GNAI2 8368.0 9095.0
GNAI3 9913.0 8209.0
GNAO1 -9920.0 -4692.0
GNAT1 2816.0 4134.0
GNAT2 4090.0 7829.0
GNAZ -6426.0 -852.0
GNB1 7951.0 9297.0
GNB2 8365.0 8530.0
GNB3 9486.0 -8169.0
GNB4 9757.0 8191.0
GNB5 -762.0 -205.0
GNE 1982.0 -5161.0
GNG10 10307.0 10252.0
GNG11 4608.0 5846.0
GNG2 -10288.0 -2836.0
GNG3 6662.0 1225.0
GNG4 -1513.0 -1627.0
GNG5 9805.0 9666.0
GNG7 -5188.0 -5336.0
GNG8 -5154.0 2284.0
GNGT2 -10923.0 -9575.0
GNPNAT1 5088.0 -9980.0
GOLGA2 -6652.0 7914.0
GOLGB1 -5170.0 -2548.0
GOLM1 -7178.0 -4636.0
GORASP1 8524.0 6879.0
GOSR1 -5651.0 3364.0
GOSR2 -1757.0 3596.0
GPAA1 3604.0 7190.0
GPLD1 -9347.0 -68.0
GPS1 -6653.0 -2413.0
GSK3A 5437.0 8275.0
GSN 10108.0 9436.0
GSPT1 8890.0 4650.0
GSPT2 -5847.0 -5423.0
GZMH -10430.0 -9033.0
H2AC11 1918.0 8407.0
H2AC20 -3045.0 2635.0
H2AC6 4729.0 7926.0
H2AW -10307.0 -8947.0
H2AZ1 7009.0 5660.0
H2BC11 3513.0 8859.0
H2BC12 7081.0 10193.0
H2BC15 -7054.0 7711.0
H2BC17 2507.0 9311.0
H2BC18 4067.0 6699.0
H2BC21 8299.0 10036.0
H2BC4 1910.0 8229.0
H2BC5 3700.0 7898.0
H2BC9 1386.0 3852.0
H2BU1 -7775.0 -6129.0
H3-3A 9562.0 8829.0
H3C15 182.5 4598.5
HARS1 -3253.0 -3345.0
HARS2 -5840.0 -2040.0
HCFC1 -1950.0 5297.0
HDAC1 -2168.0 4381.0
HDAC2 9181.0 5219.0
HDAC3 7060.0 7743.0
HDAC4 9252.0 9753.0
HDAC7 6776.0 5329.0
HDGF 8135.0 7290.0
HERC2 -10819.0 -7035.0
HERPUD1 9494.0 7472.0
HGS 813.0 5448.0
HIC1 -10596.0 -3684.0
HIF1A 7766.0 8740.0
HIF3A -7424.0 5300.0
HIPK2 -6191.0 9863.0
HLA-A -3294.0 -7605.0
HLA-B 5549.0 -2345.0
HLTF -6012.0 -9861.0
HNRNPC 7228.0 7789.0
HNRNPK 8272.0 8116.0
HSP90B1 8375.0 1593.0
HSPA5 9415.0 6475.0
HSPA8 -4222.0 -8984.0
HSPG2 -8564.0 -3950.0
HYOU1 -4725.0 352.0
IARS1 -7684.0 -8609.0
IARS2 8201.0 7487.0
ICMT -3482.0 2649.0
IDE 9379.0 9789.0
IFIH1 -104.0 -9711.0
IGFALS -7187.0 -6346.0
IGFBP2 9578.0 10092.0
IGFBP3 -6025.0 -10443.0
IGFBP4 -9602.0 -1736.0
IGFBP6 -3020.0 2951.0
IGFBP7 1257.0 9806.0
IKBKE 3422.0 7754.0
IKBKG -595.0 7203.0
IL33 -2225.0 -1120.0
INCENP -9777.0 -4626.0
ING2 1932.0 3993.0
INHBA 6744.0 3578.0
INO80 -9453.0 -58.0
INO80B -8771.0 1474.0
INO80C 8300.0 7445.0
INO80D -8542.0 -1707.0
INO80E -7673.0 -6983.0
ITIH2 -4454.0 -2211.0
ITM2B 8771.0 913.0
JOSD1 -8978.0 3969.0
JOSD2 4078.0 10170.0
KARS1 8005.0 -2267.0
KAT2A -5724.0 -9539.0
KAT2B 629.0 -1039.0
KBTBD6 -4372.0 1950.0
KBTBD7 2281.0 6552.0
KBTBD8 -6734.0 1825.0
KCTD6 6285.0 8491.0
KCTD7 -9638.0 -9919.0
KDELR1 9879.0 10352.0
KDELR2 9893.0 7875.0
KDELR3 -1354.0 -6629.0
KDM1B 5408.0 4685.0
KEAP1 1677.0 6363.0
KHSRP -1343.0 4290.0
KIF13A 9898.0 10660.0
KIF5A -6614.0 -7384.0
KIF5B 9763.0 9072.0
KIF5C -3207.0 -10063.0
KIFC3 -10281.0 6660.0
KIN 4085.0 7905.0
KLF4 -1291.0 -5737.0
KLHDC3 549.0 5181.0
KLHL11 -8639.0 -5691.0
KLHL2 10041.0 9861.0
KLHL20 -8559.0 -7700.0
KLHL21 -3809.0 -685.0
KLHL22 -9362.0 -10073.0
KLHL25 -8531.0 -9408.0
KLHL3 -8412.0 -10585.0
KLHL42 -7950.0 -3516.0
KLHL5 9233.0 3225.0
KLHL9 4068.0 3435.0
KLK1 -9201.0 -4955.0
KLK2 4896.0 6105.0
KTN1 6115.0 7195.0
L3MBTL2 -8122.0 -6280.0
LAMB1 -362.0 9598.0
LAMB2 -7353.0 -2442.0
LAMC1 7484.0 10634.0
LARGE1 -8590.0 -9364.0
LARGE2 71.0 -6535.0
LARS1 7998.0 -4102.0
LARS2 -5056.0 -1395.0
LEO1 4619.0 4039.0
LGALS1 9190.0 10543.0
LMAN1 -2101.0 -9736.0
LMAN2 6893.0 7688.0
LMAN2L 7489.0 7830.0
LMCD1 -7230.0 -7801.0
LMNA -2386.0 2195.0
LMO7 -4870.0 -8046.0
LONP2 -4025.0 -2770.0
LRR1 -1979.0 -4550.0
LRRC41 4228.0 8465.0
LSAMP -1894.0 -2051.0
LTBP1 6416.0 8528.0
LTF 9350.0 4940.0
LY6E -10567.0 -10660.0
LYPD2 -10944.0 -8933.0
LYPD3 -2827.0 -4512.0
LYPD5 2958.0 -4368.0
LYZ 10158.0 5170.0
MAGT1 4037.0 5258.0
MAN1A1 6497.0 9657.0
MAN1A2 -6602.0 1179.0
MAN1B1 -3746.0 -4312.0
MAN1C1 1396.0 -8830.0
MAN2A1 1336.0 -1270.0
MAN2A2 -4209.0 7794.0
MANEA 7385.0 -2869.0
MAP3K7 2469.0 7237.0
MARCHF6 -6986.0 224.0
MARS1 -3233.0 1396.0
MARS2 -9141.0 -9167.0
MAT2B 1423.0 -7517.0
MAVS 5118.0 9914.0
MBD1 -584.0 3510.0
MBD5 -5473.0 7027.0
MBD6 7636.0 9087.0
MBOAT4 -2712.0 -6835.0
MBTPS1 -1835.0 5184.0
MBTPS2 1231.0 5741.0
MCFD2 7974.0 9249.0
MCRS1 -3848.0 -4148.0
MDC1 -9511.0 -9378.0
MDGA1 3355.0 5855.0
MDM2 3788.0 6943.0
MDM4 1937.0 -1455.0
MELTF -2514.0 8496.0
MEN1 -8958.0 -4079.0
METTL21A 6161.0 7752.0
METTL22 -6204.0 7602.0
MFGE8 -471.0 7078.0
MGAT1 362.0 7982.0
MGAT2 -3625.0 2214.0
MGAT3 174.0 -9979.0
MGAT4A -482.0 -6981.0
MGAT4B 9034.0 9077.0
MGAT4C 1409.0 -1128.0
MGAT5 -8963.0 1454.0
MIA2 6400.0 5836.0
MIA3 40.0 -2504.0
MITF 9251.0 9793.0
MLEC -220.0 4725.0
MME -3693.0 -8367.0
MMP1 8623.0 7665.0
MOGS -5070.0 -3156.0
MPDU1 8992.0 9338.0
MPI -2165.0 -8742.0
MRPL1 5472.0 -2755.0
MRPL10 -6962.0 -1479.0
MRPL11 3734.0 890.0
MRPL12 5869.0 900.0
MRPL13 8990.0 5467.0
MRPL14 4494.0 -5447.0
MRPL15 5687.0 4250.0
MRPL16 7708.0 4729.0
MRPL17 -2940.0 -8803.0
MRPL18 6655.0 3759.0
MRPL19 6488.0 4816.0
MRPL2 -1764.0 -3998.0
MRPL20 4686.0 2223.0
MRPL21 774.0 2475.0
MRPL22 6630.0 5900.0
MRPL23 8054.0 8471.0
MRPL24 676.0 -5275.0
MRPL27 2127.0 -1096.0
MRPL28 6970.0 9066.0
MRPL3 6339.0 2917.0
MRPL30 8725.0 7479.0
MRPL32 993.0 -5141.0
MRPL33 7614.0 8247.0
MRPL34 -1934.0 -501.0
MRPL35 5994.0 -1142.0
MRPL36 -89.0 1931.0
MRPL37 1300.0 5479.0
MRPL38 2031.0 -6342.0
MRPL39 659.0 -6904.0
MRPL4 2917.0 1022.0
MRPL40 -3035.0 -1552.0
MRPL41 941.0 -3355.0
MRPL42 8661.0 -5375.0
MRPL43 -3601.0 -667.0
MRPL44 9007.0 5816.0
MRPL45 8869.0 2465.0
MRPL46 -855.0 -5997.0
MRPL47 8699.0 6733.0
MRPL48 6758.0 -615.0
MRPL49 -8361.0 -6980.0
MRPL50 7536.0 -7017.0
MRPL51 6526.0 5986.0
MRPL52 4229.0 6983.0
MRPL53 4976.0 7338.0
MRPL54 1494.0 -4985.0
MRPL55 -5398.0 -6360.0
MRPL57 3248.0 -2033.0
MRPL58 6634.0 4107.0
MRPL9 -8366.0 -6388.0
MRPS10 8384.0 6612.0
MRPS11 2353.0 4961.0
MRPS12 -2506.0 -2547.0
MRPS14 2975.0 1195.0
MRPS15 3131.0 4583.0
MRPS16 6555.0 5748.0
MRPS17 1740.0 -4036.0
MRPS18A 4120.0 1503.0
MRPS18B -1258.0 -6479.0
MRPS18C 7007.0 3024.0
MRPS2 -2269.0 -5655.0
MRPS21 -5301.0 -5158.0
MRPS22 8341.0 5060.0
MRPS23 7322.0 1678.0
MRPS24 2632.0 3061.0
MRPS25 -2451.0 -8866.0
MRPS26 -7533.0 -4281.0
MRPS27 154.0 -4059.0
MRPS28 7100.0 5411.0
MRPS30 -1675.0 -6196.0
MRPS31 923.0 783.0
MRPS33 1605.0 -7402.0
MRPS34 3806.0 2770.0
MRPS35 8160.0 5251.0
MRPS36 8813.0 8233.0
MRPS5 7858.0 8027.0
MRPS6 -5854.0 -8812.0
MRPS7 6569.0 1896.0
MRPS9 -5654.0 -5327.0
MRRF 1262.0 -4332.0
MRTFA 7162.0 9194.0
MSLN -2860.0 7051.0
MSRA 6087.0 7600.0
MSRB1 10244.0 9807.0
MSRB2 9974.0 9897.0
MSRB3 6635.0 5934.0
MT-RNR1 -4660.0 -192.0
MT-RNR2 -4826.0 4275.0
MT-TV -8649.0 -6121.0
MTA1 1434.0 -1530.0
MTFMT -4120.0 4528.0
MTIF2 6404.0 1551.0
MTIF3 7779.0 5495.0
MTRF1L 8079.0 8761.0
MUC1 9675.0 8255.0
MUC12 -9171.0 -8879.0
MUC16 -3838.0 -3439.0
MUC20 3464.0 -5169.0
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SULT1A3 6754.0 3320.0
SUMF1 9836.0 10078.0
SUMF2 -10639.0 -7655.0
SUMO1 9138.0 8090.0
SUMO2 8206.0 6024.0
SUMO3 9080.0 7937.0
SUZ12 4242.0 493.0
SYVN1 25.0 3387.0
TAB1 7080.0 3716.0
TADA2B 115.0 6392.0
TADA3 1436.0 8757.0
TAF10 4355.0 8862.0
TAF9B 7166.0 -3686.0
TARS1 6270.0 6534.0
TARS2 -6092.0 -5717.0
TATDN2 -8959.0 -7252.0
TBC1D20 -5268.0 1442.0
TBCA 7630.0 7827.0
TBCB -2257.0 4887.0
TBCC -9690.0 -8493.0
TBCD -3913.0 -6958.0
TBCE -1498.0 6539.0
TCF7L2 -10234.0 -870.0
TCP1 9179.0 4168.0
TDG 7704.0 8376.0
TECTA -7980.0 -1497.0
TF 2007.0 3922.0
TFG 9720.0 8105.0
TFPT 4130.0 7121.0
TGFA 5895.0 9650.0
TGFB1 984.0 3574.0
TGFBI 9890.0 9412.0
TGFBR1 -7710.0 -1431.0
TGFBR2 -6958.0 4321.0
TGOLN2 6907.0 10123.0
THBS1 1255.0 9820.0
THRA -7716.0 -2644.0
THRB -6667.0 1039.0
THSD1 5465.0 -5825.0
THSD4 -5193.0 -420.0
THSD7A -8644.0 -8243.0
TIMP1 6709.0 10267.0
TLN1 5974.0 9916.0
TMED10 4984.0 4383.0
TMED2 6691.0 7410.0
TMED3 3770.0 4652.0
TMED7 9644.0 9106.0
TMED9 7191.0 9462.0
TMEM115 3217.0 3929.0
TMEM129 3386.0 2625.0
TMEM132A 6517.0 5305.0
TNC -1884.0 -4659.0
TNFAIP3 -10143.0 -6698.0
TNIP1 8492.0 9165.0
TNIP2 -929.0 4907.0
TNIP3 -9267.0 -3770.0
TNKS -8859.0 -2898.0
TNKS2 642.0 4031.0
TOMM20 6419.0 -3688.0
TOMM70 -304.0 -4929.0
TOP1 9439.0 8587.0
TOP2A 3862.0 1492.0
TOP2B 456.0 1377.0
TOPORS 2495.0 932.0
TP53 -5246.0 -8954.0
TP53BP1 -8994.0 -6962.0
TPGS1 532.0 3544.0
TPGS2 2666.0 -1763.0
TPP1 9381.0 10085.0
TPR -4478.0 -7012.0
TPST1 2152.0 10253.0
TPST2 -8642.0 6809.0
TRAF2 -7822.0 -10338.0
TRAF3 3014.0 -4910.0
TRAF6 -4471.0 1582.0
TRAM1 5957.0 -3682.0
TRAPPC1 6932.0 9117.0
TRAPPC10 -10367.0 -4001.0
TRAPPC2 -9388.0 -4103.0
TRAPPC2L 4084.0 340.0
TRAPPC3 8513.0 8500.0
TRAPPC4 -6015.0 -5250.0
TRAPPC5 -685.0 471.0
TRAPPC6A -1341.0 -9288.0
TRAPPC6B 6911.0 6051.0
TRAPPC9 3787.0 8190.0
TRIM13 1180.0 1925.0
TRIM25 9125.0 8899.0
TRIM27 9100.0 8140.0
TRIM28 -6726.0 -6061.0
TRMT112 3035.0 510.0
TRRAP -9540.0 -2608.0
TSFM 9137.0 4712.0
TSPAN14 -3505.0 8543.0
TSPAN15 4314.0 -4995.0
TSPAN33 475.0 7587.0
TSPAN5 -2374.0 -411.0
TSPYL2 -5902.0 -9853.0
TSTA3 6850.0 5442.0
TTF1 3229.0 1341.0
TTL -8475.0 -305.0
TTLL1 6976.0 -4981.0
TTLL11 -5931.0 -3572.0
TTLL12 3828.0 4424.0
TTLL13P -9620.0 -959.0
TTLL3 -3131.0 138.0
TTLL4 8786.0 7882.0
TTLL5 -6678.0 3401.0
TTLL7 4818.0 6480.0
TUBA1A 8387.0 6160.0
TUBA1B 5908.0 5651.0
TUBA1C 8111.0 6802.0
TUBA3D -3044.0 -8193.0
TUBA4A -92.0 4474.0
TUBA4B -3853.0 -923.0
TUBA8 4562.0 6089.0
TUBB1 -2192.0 5599.0
TUBB2A 8824.0 9899.0
TUBB3 -2780.0 -397.0
TUBB4A -3617.0 -9555.0
TUBB4B 7592.0 5692.0
TUBB6 -4633.0 8489.0
TUFM 26.0 4585.0
TULP4 -10353.0 -1559.0
TXN 9660.0 8103.0
UAP1 -9713.0 -9507.0
UBA1 5026.0 7870.0
UBA2 5359.0 -1042.0
UBA3 10160.0 9196.0
UBA52 2067.0 260.0
UBA6 5769.0 6471.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2A 8378.0 8872.0
UBE2B 8863.0 6372.0
UBE2C 5494.0 3509.0
UBE2D1 10262.0 10093.0
UBE2D2 5413.0 5174.0
UBE2D3 9631.0 8934.0
UBE2E1 9885.0 8679.0
UBE2E3 5701.0 7288.0
UBE2F 3599.0 8133.0
UBE2G1 3382.0 7080.0
UBE2G2 945.0 -5649.0
UBE2H 4979.0 8492.0
UBE2I -1027.0 5239.0
UBE2J2 7863.0 9279.0
UBE2K 9809.0 8979.0
UBE2L3 9173.0 8427.0
UBE2L6 -3435.0 -10632.0
UBE2M 3363.0 8550.0
UBE2N 7813.0 4195.0
UBE2Q2 -7040.0 -9475.0
UBE2R2 8147.0 9175.0
UBE2S 6887.0 3531.0
UBE2T -367.0 -5197.0
UBE2V2 8803.0 5733.0
UBE2W 9550.0 8060.0
UBE2Z -8053.0 -7521.0
UBXN1 -4500.0 2432.0
UBXN7 -4238.0 5404.0
UCHL3 9318.0 3246.0
UCHL5 3830.0 -4523.0
UCN -4422.0 -2288.0
UGGT1 364.0 6869.0
UGGT2 9481.0 7067.0
UHRF2 -8362.0 -6704.0
UIMC1 9560.0 10225.0
USO1 8607.0 7741.0
USP10 9221.0 5348.0
USP11 -10967.0 -9911.0
USP12 6071.0 6628.0
USP13 -7140.0 -215.0
USP14 17.0 1934.0
USP15 7488.0 4692.0
USP16 5307.0 -4461.0
USP18 -10752.0 -10494.0
USP19 -8647.0 -341.0
USP20 -7443.0 -10527.0
USP21 -1984.0 -3521.0
USP22 381.0 8949.0
USP24 -10420.0 -7102.0
USP25 6368.0 -2554.0
USP28 -11000.0 -9568.0
USP3 8702.0 10300.0
USP30 2947.0 6122.0
USP33 5176.0 5090.0
USP34 -6599.0 1766.0
USP37 -8425.0 -5863.0
USP4 7575.0 8759.0
USP42 -9583.0 -8883.0
USP44 -6616.0 -4613.0
USP47 -5975.0 3456.0
USP48 7646.0 7022.0
USP49 4500.0 7097.0
USP5 -2500.0 1235.0
USP7 -171.0 8779.0
USP8 8356.0 8962.0
USP9X 1306.0 5792.0
VAMP2 -4429.0 -10264.0
VARS1 -3603.0 -3437.0
VARS2 -3139.0 -1959.0
VBP1 9567.0 4082.0
VCAN 10280.0 10667.0
VCP 7591.0 6702.0
VCPIP1 -2942.0 -855.0
VCPKMT -2252.0 -449.0
VDAC1 7258.0 5858.0
VDAC2 9090.0 9227.0
VDAC3 3161.0 3488.0
VDR 5697.0 10052.0
VHL -700.0 5272.0
VNN1 10163.0 10414.0
VNN2 9682.0 9921.0
VNN3 4358.0 5661.0
WAC -1830.0 6636.0
WARS1 3334.0 -8797.0
WARS2 6233.0 -6540.0
WDR20 -2136.0 1868.0
WDR48 -6698.0 -8483.0
WDR5 -1340.0 1040.0
WDR61 5735.0 -802.0
WDTC1 -6200.0 7229.0
WFS1 -9996.0 -7328.0
WIPI1 2793.0 7156.0
WRAP53 -3299.0 -5348.0
WRN -7839.0 -10190.0
WSB1 9732.0 9122.0
WSB2 9591.0 8588.0
XBP1 4413.0 894.0
XPC -10096.0 -8826.0
XPNPEP2 -10576.0 -9739.0
XRCC4 8532.0 8109.0
XRN2 10201.0 10472.0
YARS1 -3921.0 4984.0
YARS2 -2388.0 -3459.0
YIF1A 4573.0 1279.0
YKT6 1766.0 6226.0
YOD1 6941.0 7492.0
YY1 -5236.0 -1577.0
ZBED1 -2882.0 -3813.0
ZBTB16 -10578.0 8072.0
ZBTB17 -6636.0 2993.0
ZDHHC2 7757.0 4442.0
ZNF131 -4771.0 -8881.0
ZNF350 -2178.0 -448.0
ZRANB1 3511.0 -64.0



Scavenging of heme from plasma

Scavenging of heme from plasma
metric value
setSize 70
pMANOVA 3.83e-27
p.adjustMANOVA 7.46e-25
s.dist 0.513
s.low.CRP 0.192
s.high.CRP -0.476
p.low.CRP 0.00538
p.high.CRP 5.82e-12




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGHA1 6020 -8527
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
JCHAIN 5415 -8049
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960

Click HERE to show all gene set members

All member genes
low CRP high CRP
ALB 5157 1598
APOL1 1106 -9021
CD163 10141 10559
HBA1 9695 8704
HBB 9671 6093
HP 10242 10523
HPX 2028 -3809
IGHA1 6020 -8527
IGHA2 3566 -2966
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
JCHAIN 5415 -8049
LRP1 8118 10314



Vesicle-mediated transport

Vesicle-mediated transport
metric value
setSize 644
pMANOVA 5.08e-27
p.adjustMANOVA 8.66e-25
s.dist 0.316
s.low.CRP 0.2
s.high.CRP 0.245
p.low.CRP 4.78e-18
p.high.CRP 2.49e-26




Top 20 genes
Gene low CRP high CRP
STAB1 10304 10662
F5 10339 10599
VAMP7 10303 10569
CD36 10363 10493
PLA2G4A 10226 10618
HP 10242 10523
CD163 10141 10559
RAB13 10172 10518
PLIN3 10168 10515
AP1S1 10021 10574
RAB32 10118 10403
SERPINA1 10186 10295
ARF4 10147 10254
AGFG1 10229 10133
ITSN1 9926 10430
GRB2 9960 10389
GNS 9753 10593
RAB31 10008 10290
YWHAE 10079 10158
CTSZ 9796 10451

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAK1 -9042 -7217
ACBD3 4521 7353
ACTR10 9447 8995
ACTR1A 1291 7735
ACTR2 9004 9240
ACTR3 9818 8294
ADRB2 -10762 -9843
AGFG1 10229 10133
AGPAT3 7444 4388
AKT1 -5096 2421
AKT2 -7693 3004
AKT3 -8346 -9755
ALB 5157 1598
ALS2 -2405 6348
ALS2CL 4870 -10047
AMPH 198 10006
ANK1 9056 9344
ANK3 5423 -4595
ANKRD27 -9308 4286
ANKRD28 -8321 -2586
AP1B1 7607 10260
AP1G1 -1729 6706
AP1G2 -1671 -3578
AP1M1 392 8050
AP1M2 1215 549
AP1S1 10021 10574
AP1S2 7206 -5666
AP1S3 -7437 3269
AP2A1 -5326 9611
AP2A2 5529 9467
AP2B1 -8369 3155
AP2M1 7928 9269
AP2S1 8593 9630
AP3B1 8318 10381
AP3S1 9256 8625
AP4B1 -7104 452
AP4E1 7397 8614
AP4M1 -6768 4143
AP4S1 4882 -357
APOE -4921 3265
APOL1 1106 -9021
APP 10085 9961
ARCN1 4291 7676
AREG -5505 9162
ARF1 9085 10196
ARF3 7124 9257
ARF4 10147 10254
ARF5 8080 9476
ARF6 -772 2507
ARFGAP1 -2066 -296
ARFGAP2 -7117 -3644
ARFGAP3 2322 4136
ARFIP2 1294 -2246
ARFRP1 -4963 -6627
ARL1 3746 1246
ARPC1A 9171 9991
ARPC2 7187 8262
ARPC3 9674 9506
ARPC4 7777 8635
ARPC5 9932 9762
ARRB1 -5720 3058
ARRB2 8232 9058
ASPSCR1 -743 -4191
AVPR2 3307 -4195
BET1 6957 1985
BET1L -4965 -5604
BICD1 -9266 -1245
BICD2 2764 10214
BIN1 -9716 -9890
BLOC1S1 8239 10111
BLOC1S3 -8796 -8402
BLOC1S4 -7852 -6653
BLOC1S6 9410 8343
BNIP1 3526 -3540
C2CD5 -6435 -4045
CALM1 -4337 1051
CALR 8310 6954
CAPZA1 9332 9316
CAPZA2 10077 9039
CAPZB 8393 8843
CBL 1852 8579
CCZ1 2409 7285
CCZ1B 4934 2981
CD163 10141 10559
CD36 10363 10493
CD3D -7327 -10481
CD3G -8283 -10568
CD4 1506 -6863
CD55 9747 10312
CD59 6386 4199
CENPE -3770 492
CHM 3048 6845
CHML 1075 374
CHMP2A 9715 9488
CHMP2B 8303 5566
CHMP3 8652 9021
CHMP4A 6441 5030
CHMP4B 9666 9765
CHMP5 7394 5917
CHMP6 -3413 6801
CHMP7 -3563 -7134
CLINT1 -3865 5787
CLTA 9206 9264
CLTB 891 6664
CLTC 9482 10359
CLTCL1 10097 9644
CNIH1 9266 8825
CNIH2 2506 2667
CNIH3 -9428 -8506
COG1 -9533 -9241
COG2 3963 1728
COG3 3114 -4075
COG4 -3232 889
COG5 3937 3634
COG6 1615 -87
COG7 7042 7599
COG8 -5751 -901
COL1A2 4726 5641
COL4A2 -2203 4823
COL7A1 -442 8394
COLEC12 -10027 2954
COPA 6851 10178
COPB1 9548 8670
COPB2 9499 8940
COPE 5686 8054
COPG1 7245 9390
COPG2 8584 9972
COPS2 9383 7627
COPS3 8156 5701
COPS4 6317 5948
COPS5 6344 6899
COPS6 889 3896
COPS7A 3083 7494
COPS7B -6235 -3924
COPS8 3385 -3694
COPZ1 8315 6558
COPZ2 -2992 -9775
CPD 7971 10274
CSNK1D -8768 1189
CTSC -3910 5638
CTSZ 9796 10451
CTTN -1491 5397
CUX1 7781 10485
CYTH1 -10664 -10678
CYTH2 -5491 -275
CYTH3 -10590 -1995
CYTH4 290 6606
DAB2 -1315 10367
DCTN1 -4701 7431
DCTN2 9097 10370
DCTN3 3675 7530
DCTN4 5909 10148
DCTN5 -6881 5731
DCTN6 9751 9405
DENND1A 8537 8228
DENND1B -5182 -6323
DENND1C -5881 -4196
DENND2A -5846 -5035
DENND2C -619 6985
DENND2D -10549 -10519
DENND3 7771 7945
DENND4A -3739 1038
DENND4B -4584 4911
DENND4C -5334 -4689
DENND5A 8933 7373
DENND5B -5074 -5006
DENND6A -3231 7597
DENND6B 5199 1549
DNAJC6 7251 6031
DNASE2 -45 7245
DNM1 5661 -1028
DNM2 -2349 6839
DNM3 1942 8165
DTNBP1 3595 5398
DVL2 -9587 -8307
DYNC1H1 -9811 -4718
DYNC1I1 378 6338
DYNC1I2 8978 9397
DYNC1LI1 8227 7194
DYNC1LI2 909 7271
DYNLL1 6414 7208
DYNLL2 -5827 -2261
EGF 8136 8196
EPN1 5311 9662
EPN2 -8607 -4227
EPS15 5113 6773
EPS15L1 -9182 2731
EREG -2190 5005
EXOC1 9024 8457
EXOC2 -9 -5242
EXOC3 472 5375
EXOC4 3395 8923
EXOC5 7313 6215
EXOC6 10067 9636
EXOC7 -4909 6670
EXOC8 -6622 -999
F5 10339 10599
F8 7904 8494
FCHO1 -958 -7638
FCHO2 7657 8741
FNBP1 -5230 -48
FNBP1L 7579 9275
FTH1 1622 1016
FTL 9418 9788
FZD4 -10151 -6695
GABARAP 9696 8661
GABARAPL2 9925 8820
GAK -4280 4069
GALNT1 7857 7854
GALNT2 7832 9935
GAPVD1 5428 9178
GBF1 -8195 348
GCC1 -2365 674
GCC2 -4825 -7034
GDI1 6489 6456
GDI2 8435 8742
GGA1 -461 6124
GGA2 -10705 -503
GGA3 564 5909
GJB6 -7647 4705
GJC1 2210 817
GJC2 -1390 -2117
GJD3 6631 8053
GNS 9753 10593
GOLGA1 -7014 5795
GOLGA2 -6652 7914
GOLGA4 -4344 -1102
GOLGA5 6759 8402
GOLGB1 -5170 -2548
GOLIM4 603 9928
GORASP1 8524 6879
GOSR1 -5651 3364
GOSR2 -1757 3596
GPS1 -6653 -2413
GRB2 9960 10389
GRK2 3428 7104
GRK3 7770 9038
HBA1 9695 8704
HBB 9671 6093
HBEGF -922 4467
HGS 813 5448
HIP1 7210 9534
HIP1R -9741 -8533
HP 10242 10523
HPS1 1774 5625
HPS4 -7128 -7189
HPX 2028 -3809
HSP90AA1 5650 1245
HSP90B1 8375 1593
HSPA8 -4222 -8984
HSPH1 -3822 -6902
HYOU1 -4725 352
IGF2R -5530 9230
IGHA1 6020 -8527
IGHA2 3566 -2966
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
IL7R -2724 -10582
ITSN1 9926 10430
ITSN2 4513 6436
JCHAIN 5415 -8049
KDELR1 9879 10352
KDELR2 9893 7875
KDELR3 -1354 -6629
KIAA0319 -7389 -4520
KIF11 3737 2621
KIF13B -1533 8167
KIF15 -449 425
KIF16B 6483 4873
KIF18A -2850 622
KIF18B 1574 -51
KIF19 -10505 -9709
KIF1B 7790 8663
KIF1C 7961 9111
KIF20A 6379 5509
KIF20B -1910 -5769
KIF21A -9783 -10049
KIF21B -10604 -6590
KIF22 -10509 -10695
KIF23 8848 7278
KIF26A 6834 -7906
KIF26B -10289 -9057
KIF27 2910 -4715
KIF28P -8008 -5405
KIF2A -6211 -747
KIF2C 7577 4013
KIF3A -8157 -10124
KIF3B 401 7605
KIF3C -1903 8405
KIF4A -1608 5848
KIF5A -6614 -7384
KIF5B 9763 9072
KIF5C -3207 -10063
KIF6 3441 2876
KIF9 -1464 5983
KIFAP3 -5888 -4431
KIFC1 1080 -113
KIFC2 2690 -1229
KLC1 1637 6402
KLC2 -4678 -6163
KLC3 5293 7555
KLC4 -8715 -7444
LDLR 2581 7296
LDLRAP1 118 -9996
LMAN1 -2101 -9736
LMAN2 6893 7688
LMAN2L 7489 7830
LNPEP -9075 -5744
LRP1 8118 10314
LRP2 -392 6762
M6PR -618 -2291
MADD -10948 -8948
MAN1A1 6497 9657
MAN1A2 -6602 1179
MAN1C1 1396 -8830
MAN2A1 1336 -1270
MAN2A2 -4209 7794
MAP1LC3B 6882 8047
MARCO 7808 10448
MCFD2 7974 9249
MIA2 6400 5836
MIA3 40 -2504
MON1A -7153 -1907
MON1B -1853 7964
MSR1 -1194 6317
MVB12A 7215 9463
MVB12B 2169 4830
MYH9 -3200 7267
MYO1C 4706 3451
MYO5A 2173 8638
MYO6 -8930 -10031
NAA30 -4960 -9386
NAA35 -9522 -8612
NAA38 5422 9519
NAPA 4940 2147
NAPB -4472 1066
NAPG 5219 7040
NBAS -1467 4874
NECAP1 3266 3630
NECAP2 6593 3442
NEDD8 5330 8439
NSF 8767 10358
OCRL 6438 9145
OPTN -8484 -10244
PACSIN1 -11022 -10400
PACSIN2 7884 7763
PAFAH1B1 491 7762
PAFAH1B2 7578 8153
PAFAH1B3 7890 1430
PICALM 9197 10228
PIK3C2A 99 -876
PIP5K1C -4414 4334
PLA2G4A 10226 10618
PLA2G6 -10438 -10350
PLIN3 10168 10515
POLG -10398 -5722
PPP6C 9263 7953
PPP6R1 -4291 7176
PPP6R3 1461 4805
PREB 4312 7535
PRKAB1 -458 4538
PRKAB2 -6078 -3690
PRKAG1 7411 7976
PRKAG2 7267 1382
PUM1 -2856 6351
RAB10 9916 9959
RAB11A 9367 8536
RAB11B 1061 4700
RAB12 7246 1150
RAB13 10172 10518
RAB14 8765 8436
RAB18 9744 7495
RAB1A 10223 9909
RAB1B 8291 9474
RAB21 7164 6786
RAB27A 9159 9152
RAB27B -6595 4754
RAB30 -9823 -7791
RAB31 10008 10290
RAB32 10118 10403
RAB33A -10259 -9079
RAB33B 8566 5483
RAB35 -5746 3696
RAB36 3694 2526
RAB38 -7625 -1532
RAB39A 9485 8386
RAB39B -8852 -10419
RAB3A 6440 9746
RAB3GAP1 9145 6282
RAB3GAP2 4864 7377
RAB3IP 2883 6198
RAB41 -3046 -2678
RAB43 3769 5508
RAB4A 8673 6735
RAB5A 9230 7808
RAB5B -279 7773
RAB5C 8923 9415
RAB6A 8383 9332
RAB6B 3094 7305
RAB7A 9941 9609
RAB7B -9067 5680
RAB8A 1690 6186
RAB8B 6481 8127
RAB9A 5902 5709
RAB9B -6342 1453
RABEP1 -10037 -7464
RABEPK 2549 6617
RABGAP1 -824 5647
RABGEF1 7522 7888
RAC1 9345 9946
RACGAP1 4139 4294
RALA 8746 2764
RALGAPA2 7931 9867
RALGAPB -7172 1158
REPS1 -9785 -1895
REPS2 2786 8377
RGP1 -5159 7801
RHOBTB3 -10974 -5531
RHOQ 10030 8943
RIC1 4473 8485
RIN1 3246 9787
RIN2 9120 10172
RINL -10133 -8101
RINT1 4454 -8906
RPS27A -1868 -5386
SAR1B 9412 8914
SBF1 -10005 -8548
SBF2 9786 10402
SCARB1 6192 5385
SCARB2 7527 7411
SCARF1 7980 -9211
SCFD1 6826 7619
SCGB3A2 -4719 -668
SCOC 9126 -2347
SEC13 6324 5321
SEC16A -6613 6860
SEC16B -340 3720
SEC22A 5519 1741
SEC22B 9017 4952
SEC22C 2177 1557
SEC23A 8250 8136
SEC23IP 6616 2151
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SEC31A 1943 6528
SERPINA1 10186 10295
SFN 4316 -5611
SH3D19 3393 -1484
SH3GL1 6353 8238
SH3KBP1 2654 6905
SLC2A8 -9818 -10384
SNAP23 9581 8746
SNAP29 -5542 9818
SNAPIN 8469 8664
SNF8 6092 7999
SNX18 -4652 8868
SNX2 8557 9755
SNX5 -28 5823
SNX9 -3423 5481
SORT1 10328 9876
SPARC 7330 7225
SPTA1 9220 7274
SPTAN1 -10045 -9563
SPTB 9406 9121
SPTBN1 -8781 -6351
SPTBN2 -6201 -2780
SPTBN5 -7032 -3485
SRC -4936 -8846
SSC5D -6156 -4021
STAB1 10304 10662
STAB2 6753 7249
STAM 2880 1495
STAM2 8313 7133
STON1 -4325 2581
STON2 -8342 4103
STX10 9254 10297
STX16 3962 3629
STX17 -2656 -9125
STX18 3809 8897
STX4 -4764 2706
STX5 6777 7536
STX6 3663 9472
STXBP3 9718 8688
SURF4 6833 7852
SYNJ1 1280 7746
SYNJ2 -6719 -7296
SYS1 -3153 -1279
SYT1 7846 6678
SYT11 -10327 -2
SYT2 -7268 -5231
SYTL1 -8112 -8998
TBC1D1 3483 8464
TBC1D10A -10727 -9177
TBC1D10B 5424 8854
TBC1D10C -10068 -10544
TBC1D13 -8244 5356
TBC1D14 9185 9726
TBC1D15 8943 2916
TBC1D16 39 7045
TBC1D17 -6518 -8314
TBC1D2 9139 10519
TBC1D20 -5268 1442
TBC1D24 749 4875
TBC1D25 -10387 -4445
TBC1D3 837 525
TBC1D4 -1540 -10331
TBC1D7 7070 8260
TBC1D8B -288 649
TF 2007 3922
TFG 9720 8105
TFRC 3905 5758
TGFA 5895 9650
TGOLN2 6907 10123
TJP1 -85 -2268
TMED10 4984 4383
TMED2 6691 7410
TMED3 3770 4652
TMED7 9644 9106
TMED9 7191 9462
TMEM115 3217 3929
TMF1 4265 5362
TOR1A 8179 8469
TOR1B -8015 266
TPD52 -5165 -6821
TPD52L1 -6352 3475
TRAPPC1 6932 9117
TRAPPC10 -10367 -4001
TRAPPC11 7303 8864
TRAPPC12 -306 6210
TRAPPC13 5140 2337
TRAPPC2 -9388 -4103
TRAPPC2L 4084 340
TRAPPC3 8513 8500
TRAPPC4 -6015 -5250
TRAPPC5 -685 471
TRAPPC6A -1341 -9288
TRAPPC6B 6911 6051
TRAPPC8 5637 8631
TRAPPC9 3787 8190
TRIP10 2447 2170
TRIP11 950 4162
TSC1 -5608 223
TSC2 -2640 -1107
TSG101 9865 7776
TXNDC5 5836 -3635
UBA52 2067 260
UBAP1 9245 9187
UBB 7788 3835
UBC 2562 2822
UBQLN1 6829 6120
UBQLN2 8190 2894
ULK1 395 8382
USE1 -739 -2569
USO1 8607 7741
USP6NL 7087 7068
VAMP2 -4429 -10264
VAMP3 9466 8623
VAMP4 7842 7025
VAMP7 10303 10569
VAMP8 7797 7239
VPS25 8588 9314
VPS28 5467 4829
VPS36 3782 -1712
VPS37A 8256 7697
VPS37B -9060 3262
VPS37C 9329 8849
VPS45 8107 4897
VPS4A 330 3807
VPS4B 6755 6176
VPS51 -8721 -7339
VPS52 -1767 842
VPS53 -6455 255
VPS54 9881 9119
VTA1 8205 7811
VTI1A -5308 7940
WASL -3272 1473
YIPF6 8155 7019
YKT6 1766 6226
YWHAB 9116 6191
YWHAE 10079 10158
YWHAG 9489 10473
YWHAH 9385 9379
YWHAQ -6372 -2552
YWHAZ 7112 6341
ZW10 4728 3709



Classical antibody-mediated complement activation

Classical antibody-mediated complement activation
metric value
setSize 68
pMANOVA 3.04e-23
p.adjustMANOVA 4.6e-21
s.dist 0.517
s.low.CRP 0.0986
s.high.CRP -0.507
p.low.CRP 0.16
p.high.CRP 4.48e-13




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
C1QA 2730 7449
C1QB 7676 9366
C1QC 8977 9784
C1R -9046 -4725
C1S -1133 4982
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641



Signal Transduction

Signal Transduction
metric value
setSize 1869
pMANOVA 7.7e-23
p.adjustMANOVA 9.58e-21
s.dist 0.156
s.low.CRP 0.0684
s.high.CRP 0.14
p.low.CRP 9.87e-07
p.high.CRP 1.51e-23




Top 20 genes
Gene low CRP high CRP
CSF2RA 10368 10661
PPARG 10358 10670
SOCS3 10312 10656
FZD5 10298 10651
WASF1 10267 10673
S100A8 10362 10564
S100A9 10316 10598
PLA2G4A 10226 10618
GNA15 10227 10612
HRH2 10336 10492
CCR2 10299 10514
NTSR1 10297 10497
PLB1 10170 10628
ATP6V0A1 10207 10551
GRB10 10276 10479
LAMTOR1 10275 10468
FPR1 10352 10383
NUMB 10245 10465
EDNRB 10029 10678
RHOT1 10236 10427

Click HERE to show all gene set members

All member genes
low CRP high CRP
A2M -7493.0 -9192.0
AAMP -546.0 -3061.0
AATF 2358.0 6354.0
ABCA1 4951.0 6830.0
ABCG1 -6697.0 -8303.0
ABCG8 8787.0 2935.0
ABHD12 -10547.0 -6538.0
ABHD17A -10062.0 -8554.0
ABHD17B -1683.0 1264.0
ABHD17C -6145.0 -1185.0
ABHD6 -8566.0 3459.0
ABI1 7076.0 8607.0
ABI2 -8604.0 -8517.0
ABL1 -8248.0 3812.0
ABR -2370.0 8398.0
ACKR2 2518.0 3516.0
ACKR3 -10953.0 -5735.0
ACKR4 -9780.0 -4121.0
ACTA2 29.0 -4496.0
ACTB 10142.0 9915.0
ACTG1 8859.0 9583.0
ACTR2 9004.0 9240.0
ACTR3 9818.0 8294.0
ACVR1B 8950.0 10357.0
ACVR1C 4505.0 -9217.0
ACVR2A -4675.0 -10168.0
ACVR2B -7467.0 -9685.0
ACVRL1 6846.0 9750.0
ADAM10 9652.0 10284.0
ADAM12 1487.0 -6520.0
ADAM17 4487.0 10398.0
ADAP1 5757.0 9337.0
ADCY2 -3835.0 2899.0
ADCY3 9752.0 10224.0
ADCY4 4464.0 2329.0
ADCY5 -10012.0 -4366.0
ADCY6 -5852.0 -3739.0
ADCY7 -9455.0 -1458.0
ADCY9 -8919.0 1933.0
ADGRE1 9595.0 10180.0
ADGRE2 5887.0 8346.0
ADGRE3 -6203.0 -8538.0
ADGRE5 -10156.0 -1430.0
ADM 10088.0 10504.0
ADM2 9999.0 5782.0
ADORA1 -9875.0 -6827.0
ADORA2A -1381.0 -1440.0
ADORA2B 6712.0 10334.0
ADORA3 5580.0 9041.0
ADRA2A -4933.0 4150.0
ADRB1 -10531.0 -6313.0
ADRB2 -10762.0 -9843.0
AGO1 -7318.0 8369.0
AGO2 -5942.0 3135.0
AGO3 2201.0 1603.0
AGO4 9707.0 10033.0
AGRN -10089.0 -10536.0
AHCTF1 -3128.0 -3580.0
AHCYL1 4949.0 8470.0
AKAP13 -7083.0 7342.0
AKR1C1 5170.0 -820.0
AKR1C3 -10816.0 -7648.0
AKT1 -5096.0 2421.0
AKT1S1 6861.0 8235.0
AKT2 -7693.0 3004.0
AKT3 -8346.0 -9755.0
ALDH1A1 -8683.0 -10694.0
ALDH1A2 9503.0 9252.0
ALDH8A1 -2910.0 -7670.0
AMER1 -8746.0 -9063.0
AMH 645.0 -2518.0
AMOT -10942.0 -10614.0
AMOTL1 638.0 9076.0
ANGPT1 -2624.0 1229.0
ANOS1 5298.0 8339.0
ANXA1 8538.0 8818.0
AP2A1 -5326.0 9611.0
AP2A2 5529.0 9467.0
AP2B1 -8369.0 3155.0
AP2M1 7928.0 9269.0
AP2S1 8593.0 9630.0
APBB1IP 10051.0 8873.0
APC -2802.0 3982.0
APH1A 3292.0 4183.0
APH1B 5962.0 8800.0
APOA2 7224.0 7075.0
APOE -4921.0 3265.0
APOM 4751.0 4731.0
APP 10085.0 9961.0
AR -1905.0 4565.0
ARAF 939.0 2823.0
ARAP1 5402.0 9386.0
ARAP2 -10790.0 -9779.0
ARAP3 6693.0 8168.0
AREG -5505.0 9162.0
ARF6 -772.0 2507.0
ARHGAP1 -2677.0 5714.0
ARHGAP10 1783.0 -6828.0
ARHGAP11A 653.0 5998.0
ARHGAP11B -7864.0 -135.0
ARHGAP12 -6224.0 -724.0
ARHGAP15 6659.0 -1708.0
ARHGAP17 470.0 -4989.0
ARHGAP18 7499.0 10079.0
ARHGAP19 5665.0 8649.0
ARHGAP21 -2600.0 6069.0
ARHGAP22 -8091.0 1630.0
ARHGAP23 4287.0 6819.0
ARHGAP24 7710.0 10070.0
ARHGAP25 -10345.0 -6678.0
ARHGAP26 3515.0 9801.0
ARHGAP27 -3379.0 7795.0
ARHGAP28 5007.0 2895.0
ARHGAP29 6356.0 10326.0
ARHGAP30 -2445.0 5941.0
ARHGAP31 7393.0 6996.0
ARHGAP32 4298.0 500.0
ARHGAP33 1587.0 -5243.0
ARHGAP35 -7422.0 1698.0
ARHGAP39 -5468.0 -6443.0
ARHGAP4 -4354.0 443.0
ARHGAP42 -5233.0 -4163.0
ARHGAP44 2181.0 6072.0
ARHGAP5 3607.0 -9231.0
ARHGAP6 -75.0 8986.0
ARHGAP8 -10489.0 -9639.0
ARHGAP9 -4182.0 7692.0
ARHGDIA 5314.0 7347.0
ARHGDIB 8886.0 9656.0
ARHGEF1 -5037.0 -6854.0
ARHGEF10 -253.0 -5097.0
ARHGEF10L 1008.0 -9830.0
ARHGEF11 9942.0 10411.0
ARHGEF12 -8497.0 4475.0
ARHGEF17 6692.0 7482.0
ARHGEF18 -9256.0 -4500.0
ARHGEF19 -6155.0 -4627.0
ARHGEF2 -2042.0 5713.0
ARHGEF25 -10540.0 -9958.0
ARHGEF26 -3861.0 -1912.0
ARHGEF3 -10101.0 -10061.0
ARHGEF35 852.0 -1203.0
ARHGEF38 -4607.0 -537.0
ARHGEF39 -6906.0 -6647.0
ARHGEF4 6331.0 -6823.0
ARHGEF40 8210.0 10433.0
ARHGEF5 -889.0 -9171.0
ARHGEF6 4899.0 4608.0
ARHGEF7 -9779.0 4261.0
ARHGEF9 -10620.0 -9219.0
ARL2 3396.0 3132.0
ARL4C -10983.0 -10518.0
ARPC1A 9171.0 9991.0
ARPC1B 9189.0 10351.0
ARPC2 7187.0 8262.0
ARPC3 9674.0 9506.0
ARPC4 7777.0 8635.0
ARPC5 9932.0 9762.0
ARRB1 -5720.0 3058.0
ARRB2 8232.0 9058.0
ASH2L 5370.0 7543.0
ATF1 9088.0 8764.0
ATF2 8316.0 2303.0
ATN1 2216.0 1736.0
ATP2A1 -4842.0 -734.0
ATP2A2 7987.0 8967.0
ATP2A3 -10436.0 -1355.0
ATP6AP1 4019.0 10005.0
ATP6V0A1 10207.0 10551.0
ATP6V0A2 -10746.0 -8412.0
ATP6V0B 9087.0 9653.0
ATP6V0C 9621.0 9869.0
ATP6V0D1 10069.0 10341.0
ATP6V0E1 8986.0 9188.0
ATP6V0E2 -4949.0 -10370.0
ATP6V1A 10093.0 10441.0
ATP6V1B2 10130.0 10122.0
ATP6V1C1 10266.0 9394.0
ATP6V1C2 -1408.0 -231.0
ATP6V1D 9919.0 9993.0
ATP6V1E1 9071.0 8178.0
ATP6V1E2 9253.0 5767.0
ATP6V1F 8059.0 6808.0
ATP6V1G1 7364.0 3710.0
ATP6V1G2 -3663.0 -8648.0
ATP6V1H 8628.0 8476.0
AURKB 720.0 709.0
AVPR1A -3313.0 546.0
AVPR2 3307.0 -4195.0
AXIN1 -10501.0 -8999.0
AXIN2 2553.0 -7267.0
AXL -10913.0 -9565.0
B4GALT1 -3872.0 6820.0
B9D2 8072.0 7037.0
BAD 5612.0 7891.0
BAG4 8401.0 10165.0
BAIAP2 -5772.0 -4014.0
BAMBI 2874.0 9983.0
BAX 6346.0 6448.0
BCL2 5399.0 -4548.0
BCL2L1 9471.0 8431.0
BCL2L11 7146.0 9131.0
BCL9 291.0 -1249.0
BCL9L -10134.0 -10229.0
BCO2 -8749.0 -2570.0
BCR -10783.0 -4877.0
BEX3 7328.0 7650.0
BIRC2 8116.0 2944.0
BIRC3 2030.0 -10298.0
BIRC5 5078.0 5144.0
BMI1 -1361.0 -6301.0
BMPR1A -2259.0 -4588.0
BMPR2 -3074.0 8763.0
BRAF -5814.0 3049.0
BRAP 6562.0 6795.0
BRK1 5824.0 7761.0
BTK 5823.0 9633.0
BTRC -7062.0 1812.0
BUB1 6421.0 -1374.0
BUB1B 4796.0 1113.0
BUB3 -6407.0 -9998.0
C3 -10957.0 -10571.0
C3AR1 8008.0 9376.0
C5 6559.0 4756.0
C5AR1 9773.0 10201.0
C5AR2 8236.0 7910.0
CAB39 9229.0 8388.0
CAB39L 2331.0 4228.0
CALCRL 9216.0 6270.0
CALM1 -4337.0 1051.0
CAMK2D -5436.0 -9961.0
CAMK2G 3580.0 -6522.0
CAMK4 918.0 -10447.0
CAMKK1 -1555.0 7184.0
CAMKK2 8110.0 8331.0
CAMKMT 4722.0 4211.0
CARM1 9302.0 10024.0
CASP10 2384.0 -199.0
CASP2 -6424.0 -1786.0
CASP3 4165.0 2978.0
CASP8 -9202.0 -9212.0
CASP9 4638.0 9486.0
CASR -6706.0 -1546.0
CAV1 1798.0 -1413.0
CAV2 3861.0 657.0
CBFB 2611.0 3949.0
CBL 1852.0 8579.0
CBX2 -8946.0 -3592.0
CBX4 -8089.0 61.0
CBX6 2343.0 6778.0
CBX8 2677.0 6583.0
CBY1 -920.0 -9013.0
CCDC88C -10840.0 -9433.0
CCL2 -10551.0 -10635.0
CCL28 -6163.0 -10225.0
CCL3 -1192.0 -5558.0
CCL4 -10973.0 -8565.0
CCL5 -10431.0 -10290.0
CCNC 8958.0 4374.0
CCND1 -3107.0 -2342.0
CCND3 -655.0 9164.0
CCNE1 -6448.0 -9772.0
CCNK -2710.0 4495.0
CCNT1 -9147.0 -4867.0
CCNT2 -206.0 -1240.0
CCR1 10287.0 9826.0
CCR10 5632.0 -3150.0
CCR2 10299.0 10514.0
CCR3 -8499.0 -10590.0
CCR4 -5055.0 -9175.0
CCR5 -9310.0 -7370.0
CCR6 -1173.0 -9034.0
CCR7 794.0 -7393.0
CCR8 1523.0 -9487.0
CCR9 7169.0 -1973.0
CCRL2 8721.0 9354.0
CD19 -5755.0 -965.0
CD28 -328.0 -10542.0
CD55 9747.0 10312.0
CD80 -7610.0 -7443.0
CD86 6726.0 -1548.0
CDC14A -1891.0 -9901.0
CDC14B 321.0 -3250.0
CDC20 3581.0 3590.0
CDC37 2418.0 5331.0
CDC42 9246.0 8570.0
CDC42EP2 7852.0 6206.0
CDC42EP3 10150.0 9452.0
CDC73 5260.0 6248.0
CDCA8 -1406.0 -3171.0
CDH1 -10326.0 -6171.0
CDK1 7292.0 -2497.0
CDK2 -3816.0 1587.0
CDK4 -5111.0 -8839.0
CDK5 9150.0 10447.0
CDK5R1 -3681.0 4421.0
CDK8 -1289.0 2360.0
CDK9 -10105.0 1292.0
CDKN1A -1680.0 4429.0
CDKN1B -8668.0 -5917.0
CDKN2B 6243.0 10124.0
CDON -1566.0 -7870.0
CENPA 6546.0 3310.0
CENPC -9207.0 -10628.0
CENPE -3770.0 492.0
CENPF -2426.0 3671.0
CENPH 3022.0 -7832.0
CENPI -1240.0 -583.0
CENPK -1279.0 -8774.0
CENPL -10476.0 -8162.0
CENPM 5939.0 -7852.0
CENPN 2223.0 -2465.0
CENPO -10317.0 2896.0
CENPP -10903.0 -7212.0
CENPQ -2047.0 -4329.0
CENPT -6968.0 -8192.0
CENPU -1749.0 -3457.0
CETP 8400.0 1851.0
CFL1 9368.0 9341.0
CFLAR 7530.0 7738.0
CGN 5578.0 -907.0
CHD1 3926.0 2305.0
CHD3 -9906.0 -8152.0
CHD4 -9329.0 -2257.0
CHD8 -9631.0 4278.0
CHEK1 5702.0 -3830.0
CHN1 677.0 -9266.0
CHN2 6465.0 6390.0
CHRM5 -7059.0 -4786.0
CHUK 9608.0 9191.0
CILP -2633.0 -10014.0
CIT -3951.0 -1032.0
CKAP5 -7468.0 -909.0
CLASP1 -10137.0 3500.0
CLASP2 1451.0 2684.0
CLIP1 9575.0 9752.0
CLIP3 -5962.0 -9879.0
CLTA 9206.0 9264.0
CLTB 891.0 6664.0
CLTC 9482.0 10359.0
CMKLR1 -10814.0 -7141.0
CNGB1 3562.0 2056.0
CNKSR1 3442.0 -9142.0
CNKSR2 1572.0 -137.0
CNOT6L -8999.0 -10119.0
CNR1 -1330.0 8252.0
CNR2 -10581.0 -2009.0
COL4A2 -2203.0 4823.0
COL4A3 -3308.0 2359.0
COL4A4 -4580.0 1101.0
COL6A1 1098.0 -4933.0
COL6A2 -10262.0 -8642.0
COL6A3 8171.0 2868.0
COL9A2 -10365.0 -5048.0
COL9A3 9376.0 5845.0
CPT1A 2948.0 6756.0
CPT1B 586.0 -4472.0
CRABP2 466.0 3981.0
CREB1 2938.0 -595.0
CREBBP -9358.0 1958.0
CRHBP 5189.0 5868.0
CRHR2 -7686.0 823.0
CRK 9214.0 9663.0
CRKL -1879.0 4224.0
CSF2RA 10368.0 10661.0
CSF2RB 9224.0 5475.0
CSK -2015.0 6501.0
CSNK1A1 8036.0 9059.0
CSNK1E -9314.0 -5872.0
CSNK1G2 -7707.0 1858.0
CSNK2A1 1926.0 9964.0
CSNK2A2 136.0 9661.0
CSNK2B 4787.0 4600.0
CTBP1 -9138.0 -4408.0
CTBP2 -7717.0 6437.0
CTNNA1 9901.0 10587.0
CTNNB1 1446.0 7186.0
CTNNBIP1 7848.0 8535.0
CTNND1 -511.0 -4113.0
CTSD 9997.0 10635.0
CTTN -1491.0 5397.0
CUL1 7475.0 -10175.0
CUL3 7012.0 8018.0
CUL5 8446.0 4656.0
CX3CR1 -10730.0 -6635.0
CXCL1 7627.0 4227.0
CXCL10 7706.0 -10646.0
CXCL16 4289.0 10014.0
CXCL2 2912.0 3723.0
CXCL3 -466.0 2892.0
CXCL5 3706.0 2210.0
CXCL8 5888.0 -3003.0
CXCL9 967.0 -10673.0
CXCR1 3353.0 4270.0
CXCR2 5266.0 1302.0
CXCR3 -9325.0 -10580.0
CXCR4 -1821.0 1007.0
CXCR5 -9287.0 -7668.0
CXCR6 -8620.0 -9662.0
CXXC4 -9192.0 2383.0
CXXC5 -10464.0 -1667.0
CYBA 5409.0 8122.0
CYBB 10294.0 9839.0
CYFIP1 10019.0 10571.0
CYFIP2 -10388.0 -8406.0
CYLD 3384.0 -10382.0
CYP4V2 -6516.0 -5389.0
CYSLTR1 211.0 -7053.0
CYSLTR2 1991.0 -7665.0
DAAM1 -2071.0 8596.0
DAB2IP -8908.0 -5773.0
DACT1 7913.0 -1020.0
DAGLA -9795.0 -7353.0
DAGLB -390.0 9293.0
DDX5 -9939.0 -6160.0
DEPDC1B 2724.0 2444.0
DEPDC7 4916.0 -1122.0
DERL2 5626.0 4860.0
DGKA 1996.0 -8807.0
DGKD -10564.0 796.0
DGKE -5951.0 -9294.0
DGKG 9117.0 9128.0
DGKH -1070.0 -250.0
DGKK -9484.0 -7897.0
DGKQ -9702.0 -6805.0
DGKZ -8776.0 -6149.0
DHRS3 -10524.0 -10084.0
DHRS4 4479.0 567.0
DHRS9 6297.0 3936.0
DIAPH1 -9285.0 3050.0
DIAPH2 9219.0 10464.0
DIAPH3 4614.0 -892.0
DISP2 -4113.0 -8316.0
DLAT 1761.0 3102.0
DLC1 1345.0 9729.0
DLD 8939.0 9407.0
DLG1 -1129.0 -3343.0
DLG2 -5967.0 41.0
DLG3 -9607.0 -10641.0
DLG4 9782.0 9451.0
DLGAP5 5537.0 1838.0
DLL1 -10127.0 -10367.0
DNAJB1 -6048.0 -7449.0
DNAL4 3405.0 3820.0
DNM1 5661.0 -1028.0
DNM2 -2349.0 6839.0
DNM3 1942.0 8165.0
DOCK1 2337.0 9856.0
DOCK3 3341.0 -6755.0
DOCK7 -2076.0 -2321.0
DOK1 7917.0 9256.0
DRAP1 -8937.0 -4039.0
DRD4 -8902.0 -8922.0
DSN1 -8664.0 -5515.0
DTX1 4133.0 -2976.0
DTX2 6455.0 6669.0
DTX4 -8103.0 7893.0
DUSP1 5484.0 7971.0
DUSP10 -1562.0 1761.0
DUSP16 -4653.0 -6088.0
DUSP2 -10154.0 -5293.0
DUSP3 10238.0 10410.0
DUSP4 -3900.0 -8336.0
DUSP5 -10770.0 -10188.0
DUSP6 7156.0 -2241.0
DUSP7 -5905.0 -3113.0
DUSP8 -9809.0 -10041.0
DVL1 427.0 -3597.0
DVL2 -9587.0 -8307.0
DVL3 -7366.0 7767.0
DYNC1H1 -9811.0 -4718.0
DYNC1I1 378.0 6338.0
DYNC1I2 8978.0 9397.0
DYNC1LI1 8227.0 7194.0
DYNC1LI2 909.0 7271.0
DYNC2H1 -7463.0 -754.0
DYNLL1 6414.0 7208.0
DYNLL2 -5827.0 -2261.0
E2F1 807.0 4632.0
E2F3 -1851.0 7284.0
E2F4 7088.0 5636.0
E2F5 -6568.0 -5165.0
EBAG9 -1352.0 -3323.0
ECE1 9311.0 8785.0
ECT2 7495.0 6429.0
EDN1 2655.0 -7146.0
EDNRB 10029.0 10678.0
EED -2060.0 -3357.0
EEF2K -9753.0 -8831.0
EEPD1 7517.0 4410.0
EFCAB7 3028.0 -4309.0
EGF 8136.0 8196.0
EGR1 7178.0 6141.0
EGR2 5175.0 -1833.0
EGR3 -434.0 770.0
EIF4B 2213.0 1367.0
EIF4E 8016.0 7576.0
EIF4EBP1 6719.0 6918.0
EIF4G1 5724.0 10120.0
ELF3 2823.0 -1288.0
ELK1 5371.0 2922.0
ELMO1 3674.0 6433.0
ELMO2 -6937.0 7218.0
EP300 -2315.0 7280.0
EPAS1 191.0 9357.0
EPN1 5311.0 9662.0
EPOR -2452.0 6422.0
EPS15 5113.0 6773.0
EPS15L1 -9182.0 2731.0
ERBB2 -11003.0 -9975.0
ERBB3 -597.0 1233.0
ERBIN -1073.0 2273.0
ERCC6L -1539.0 2177.0
EREG -2190.0 5005.0
ERLEC1 3753.0 5744.0
ESR1 -6841.0 -8227.0
ESR2 -5996.0 -9163.0
ESRP2 -8215.0 -6062.0
ETV4 -1140.0 -2116.0
EVC -5043.0 1359.0
EVC2 -5152.0 -5282.0
EVL -9748.0 -10471.0
EZH2 -3198.0 -8251.0
F11R 8810.0 7916.0
F2R -10475.0 -7685.0
F2RL1 9484.0 8008.0
F2RL2 -8189.0 1891.0
F2RL3 -5912.0 4363.0
FABP5 6772.0 7102.0
FADD -3902.0 4370.0
FAM13A 8947.0 6611.0
FAM13B -9088.0 -7520.0
FAS 8966.0 1600.0
FASLG -10999.0 -10620.0
FASN -4442.0 -2375.0
FBXW7 -8232.0 -6782.0
FCER2 -3881.0 -3466.0
FER 5046.0 1870.0
FES 9561.0 10580.0
FFAR2 7856.0 4166.0
FFAR3 1842.0 5993.0
FFAR4 1116.0 1304.0
FGD2 2616.0 8610.0
FGD3 -5980.0 57.0
FGD4 9353.0 10327.0
FGF2 8825.0 5391.0
FGF22 -4199.0 -8205.0
FGF23 1297.0 -7622.0
FGF7 -1811.0 -5146.0
FGF9 -7810.0 -8061.0
FGFBP2 -11021.0 -9906.0
FGFBP3 -6257.0 -7616.0
FGFR1 -9793.0 -95.0
FGFR2 -10432.0 -10034.0
FGFR4 -1488.0 -4510.0
FGFRL1 -10343.0 -8295.0
FKBP1A 10270.0 9273.0
FKBP4 -833.0 414.0
FKBP5 8117.0 10444.0
FLNA -8851.0 2557.0
FLRT2 -2193.0 -3379.0
FLT1 5294.0 9048.0
FLT3 -1564.0 9968.0
FLT3LG 4903.0 -10389.0
FLT4 -9729.0 -9204.0
FMNL1 -6172.0 966.0
FMNL2 -10371.0 273.0
FMNL3 -10835.0 -9419.0
FN1 9912.0 6648.0
FNTA 3450.0 -3347.0
FNTB 8850.0 5246.0
FOS 7518.0 2641.0
FOSB 930.0 -6572.0
FOSL1 9964.0 9367.0
FOXO1 -8890.0 -9341.0
FOXO3 2533.0 10065.0
FOXO4 -2621.0 6949.0
FOXO6 -10497.0 -4221.0
FPR1 10352.0 10383.0
FPR2 10305.0 10056.0
FPR3 -10619.0 -10010.0
FRAT1 7458.0 9214.0
FRAT2 9872.0 8877.0
FRK -3103.0 1427.0
FRS2 52.0 35.0
FRS3 9115.0 9931.0
FSTL1 8734.0 8947.0
FSTL3 9917.0 10500.0
FURIN 7688.0 10324.0
FUZ -3316.0 604.0
FYN -10683.0 -7016.0
FZD1 -118.0 3961.0
FZD2 6397.0 6508.0
FZD3 66.0 -3481.0
FZD4 -10151.0 -6695.0
FZD5 10298.0 10651.0
FZD6 -3983.0 -5942.0
FZD7 -9241.0 -5379.0
FZD8 -9803.0 -264.0
GAB1 3626.0 8241.0
GAB2 6405.0 10289.0
GABBR1 5074.0 -1382.0
GABRB3 -335.0 -181.0
GABRG2 6040.0 -174.0
GALNT3 -5321.0 762.0
GALR1 5733.0 5551.0
GAS1 -9578.0 -8317.0
GAS8 8692.0 4870.0
GATA3 -8401.0 -10666.0
GATAD2A -7926.0 1424.0
GATAD2B -7823.0 241.0
GDI1 6489.0 6456.0
GDI2 8435.0 8742.0
GFAP 6411.0 6766.0
GFRA2 -10227.0 -4534.0
GGA3 564.0 5909.0
GHRL -6168.0 -9863.0
GHSR 1833.0 -5960.0
GIPR -9804.0 -10690.0
GLI1 1145.0 -1843.0
GMIP 1455.0 8835.0
GNA11 5927.0 -295.0
GNA12 3200.0 3712.0
GNA13 3919.0 6618.0
GNA15 10227.0 10612.0
GNAI1 5305.0 5103.0
GNAI2 8368.0 9095.0
GNAI3 9913.0 8209.0
GNAL -4722.0 -4374.0
GNAO1 -9920.0 -4692.0
GNAQ 10128.0 9401.0
GNAS 4056.0 6487.0
GNAT1 2816.0 4134.0
GNAT2 4090.0 7829.0
GNAZ -6426.0 -852.0
GNB1 7951.0 9297.0
GNB2 8365.0 8530.0
GNB3 9486.0 -8169.0
GNB4 9757.0 8191.0
GNB5 -762.0 -205.0
GNG10 10307.0 10252.0
GNG11 4608.0 5846.0
GNG2 -10288.0 -2836.0
GNG3 6662.0 1225.0
GNG4 -1513.0 -1627.0
GNG5 9805.0 9666.0
GNG7 -5188.0 -5336.0
GNG8 -5154.0 2284.0
GNGT2 -10923.0 -9575.0
GNRH1 -1009.0 -4091.0
GNRHR2 -2653.0 461.0
GOLGA7 5151.0 3331.0
GOPC -4481.0 -5954.0
GPAM -8942.0 -5191.0
GPBAR1 1812.0 -9767.0
GPC1 -7727.0 -2335.0
GPC2 -1014.0 -9320.0
GPC4 -5640.0 -8045.0
GPER1 9698.0 10640.0
GPNMB -6786.0 2312.0
GPR132 -9619.0 -2207.0
GPR15 1481.0 -10196.0
GPR150 -7161.0 -9626.0
GPR161 4065.0 -6675.0
GPR18 -9674.0 -10390.0
GPR183 -5234.0 -10583.0
GPR20 -11005.0 -9509.0
GPR25 -10356.0 -9393.0
GPR27 9856.0 10288.0
GPR35 3969.0 8425.0
GPR37L1 6456.0 6356.0
GPR55 -6367.0 -10463.0
GPR65 1821.0 6956.0
GPR68 -10922.0 -10670.0
GPR83 -6758.0 2713.0
GPR84 10189.0 9570.0
GPS2 -3941.0 -2386.0
GPSM1 -6831.0 -4944.0
GPSM2 7402.0 6575.0
GPSM3 5850.0 6189.0
GRAP -1421.0 -10048.0
GRAP2 -2556.0 4557.0
GRB10 10276.0 10479.0
GRB2 9960.0 10389.0
GREB1 -7076.0 -3613.0
GREM2 9421.0 -1499.0
GRIN2D 6165.0 8087.0
GRK2 3428.0 7104.0
GRK3 7770.0 9038.0
GRK4 -8627.0 4813.0
GRK5 -8120.0 -2997.0
GRK6 -255.0 5898.0
GRK7 -9094.0 -7603.0
GRM2 -7177.0 -9312.0
GRM6 2639.0 1883.0
GRPR 3998.0 -2736.0
GSK3A 5437.0 8275.0
GSK3B 4111.0 7308.0
GTF2A1 3704.0 2800.0
GTF2A2 9512.0 8125.0
GTF2F1 -4830.0 5852.0
GTF2F2 7868.0 6958.0
GUCA1B -1245.0 1393.0
GUCY2D -10775.0 -392.0
GZMB -11006.0 -10285.0
H2AC20 -3045.0 2635.0
H2AC6 4729.0 7926.0
H2AJ 8738.0 10604.0
H2AZ1 7009.0 5660.0
H2AZ2 -809.0 1701.0
H2BC11 3513.0 8859.0
H2BC12 7081.0 10193.0
H2BC15 -7054.0 7711.0
H2BC17 2507.0 9311.0
H2BC21 8299.0 10036.0
H2BC4 1910.0 8229.0
H2BC5 3700.0 7898.0
H2BC9 1386.0 3852.0
H2BU1 -7775.0 -6129.0
H3-3A 9562.0 8829.0
H3C15 182.5 4598.5
HBEGF -922.0 4467.0
HCAR1 -4492.0 4879.0
HCAR2 6499.0 -5589.0
HCAR3 2048.0 -9821.0
HDAC1 -2168.0 4381.0
HDAC10 2072.0 1157.0
HDAC11 2954.0 4635.0
HDAC2 9181.0 5219.0
HDAC3 7060.0 7743.0
HDAC4 9252.0 9753.0
HDAC5 -1101.0 439.0
HDAC6 -8079.0 -3650.0
HDAC7 6776.0 5329.0
HDAC8 2416.0 8799.0
HDAC9 6238.0 -23.0
HEBP1 10024.0 8451.0
HES1 -8727.0 -5967.0
HGF 8952.0 9949.0
HGS 813.0 5448.0
HHAT -7344.0 -8847.0
HIF1A 7766.0 8740.0
HNRNPA1 3354.0 397.0
HNRNPF 5903.0 5564.0
HNRNPH1 1972.0 -6223.0
HNRNPM 6832.0 5561.0
HRAS 2906.0 -3843.0
HRH2 10336.0 10492.0
HRH4 -6982.0 -6622.0
HSD17B1 -1265.0 -2218.0
HSP90AA1 5650.0 1245.0
HSP90AB1 4616.0 -5342.0
HSPB1 2287.0 921.0
HSPG2 -8564.0 -3950.0
HTR6 5090.0 -3526.0
HTR7 -2291.0 -4337.0
ICMT -3482.0 2649.0
ICOS 2053.0 -9847.0
ID1 -4311.0 7412.0
ID2 -10964.0 -4657.0
ID3 -9464.0 -7014.0
IER3 8169.0 6306.0
IFT122 1787.0 7293.0
IFT140 3600.0 -1286.0
IFT172 -9559.0 -7206.0
IFT52 1544.0 3761.0
IFT57 -1610.0 5815.0
IFT88 3657.0 3328.0
IGF1R -505.0 3729.0
IKBKB -6356.0 -1160.0
IKBKG -595.0 7203.0
IKZF1 -8374.0 -4013.0
IL1RAP -137.0 7646.0
IL1RL1 4851.0 -7621.0
IL2RA 2298.0 -5478.0
IL2RB -10992.0 -10437.0
IL2RG -9921.0 -10217.0
IL33 -2225.0 -1120.0
IL3RA -7725.0 -10665.0
IL5RA -9017.0 -10618.0
IL6R 9817.0 7220.0
IL6ST 8195.0 4822.0
INCENP -9777.0 -4626.0
INHBA 6744.0 3578.0
INPP5B -9344.0 -2850.0
INSL3 7721.0 3553.0
INSR 6229.0 10310.0
INTU -2152.0 2392.0
IQCE 7524.0 9978.0
IQGAP1 6734.0 9841.0
IQGAP2 3533.0 9892.0
IQGAP3 3687.0 5011.0
IRAK1 2858.0 6473.0
IRS1 1115.0 1691.0
IRS2 3826.0 10432.0
ITCH -3904.0 5799.0
ITGA2 4859.0 -2582.0
ITGA2B 8831.0 9692.0
ITGA3 -5445.0 -9086.0
ITGAV 4141.0 7107.0
ITGB1 -332.0 1996.0
ITGB3 7696.0 8680.0
ITGB3BP -5952.0 -4292.0
ITPR1 -9755.0 -3689.0
ITPR2 4786.0 9335.0
ITPR3 -8426.0 -7902.0
ITSN1 9926.0 10430.0
JAG1 8281.0 9220.0
JAG2 -6115.0 -8753.0
JAK1 -10460.0 -6095.0
JAK2 8894.0 -2339.0
JAK3 9823.0 8824.0
JUN 481.0 -1015.0
JUNB 7420.0 5447.0
JUND -1022.0 -5794.0
JUP -10174.0 -7667.0
KALRN 1792.0 -5605.0
KANK1 3444.0 -6788.0
KAT2A -5724.0 -9539.0
KAT2B 629.0 -1039.0
KAT5 310.0 2288.0
KBTBD7 2281.0 6552.0
KCTD6 6285.0 8491.0
KDM1A -8434.0 -1742.0
KDM1B 5408.0 4685.0
KDM3A -10046.0 -10564.0
KDM4A -7903.0 2514.0
KDM4B 4813.0 8095.0
KDM4C -10769.0 -2441.0
KEL -3219.0 7329.0
KHDRBS1 4434.0 5719.0
KHDRBS2 -7666.0 -2956.0
KIDINS220 3495.0 8272.0
KIF14 1247.0 1989.0
KIF18A -2850.0 622.0
KIF2A -6211.0 -747.0
KIF2C 7577.0 4013.0
KIF3A -8157.0 -10124.0
KIF5A -6614.0 -7384.0
KIF5B 9763.0 9072.0
KIF7 -10668.0 -8372.0
KISS1R 9433.0 -4749.0
KIT -10558.0 -7492.0
KL 5898.0 10387.0
KLC1 1637.0 6402.0
KLC2 -4678.0 -6163.0
KLC3 5293.0 7555.0
KLC4 -8715.0 -7444.0
KLHL12 1730.0 9303.0
KLK2 4896.0 6105.0
KMT2D -7609.0 3814.0
KNL1 -4279.0 3987.0
KNTC1 -933.0 -4604.0
KPNA2 -2381.0 -2173.0
KRAS 4388.0 5328.0
KREMEN1 10089.0 10339.0
KREMEN2 -7711.0 -1116.0
KSR1 -1842.0 5006.0
KSR2 -9743.0 -472.0
KTN1 6115.0 7195.0
LAMA1 -593.0 5278.0
LAMA2 -10710.0 -6242.0
LAMA4 -4832.0 3441.0
LAMA5 832.0 -94.0
LAMB1 -362.0 9598.0
LAMB2 -7353.0 -2442.0
LAMB3 2077.0 6000.0
LAMC1 7484.0 10634.0
LAMC3 2300.0 -4489.0
LAMTOR1 10275.0 10468.0
LAMTOR2 6251.0 9811.0
LAMTOR3 9336.0 8131.0
LAMTOR4 -1656.0 2851.0
LAMTOR5 9968.0 8801.0
LAT -8158.0 -10401.0
LATS1 2510.0 653.0
LATS2 -3446.0 8753.0
LCK -9185.0 -10569.0
LDLR 2581.0 7296.0
LEF1 4995.0 -9671.0
LEO1 4619.0 4039.0
LEPR 6442.0 8474.0
LFNG -9696.0 -5364.0
LGR4 1620.0 2550.0
LGR6 -10911.0 -9730.0
LIMK1 2972.0 6500.0
LIMK2 9807.0 6997.0
LIN7B -2699.0 458.0
LINC01139 1464.0 -389.0
LPAR1 9651.0 5171.0
LPAR2 2828.0 3349.0
LPAR3 2106.0 -6610.0
LPAR5 -10906.0 -6325.0
LPAR6 9794.0 -5359.0
LPL -4695.0 5136.0
LRIG1 -3350.0 -10151.0
LRP1 8118.0 10314.0
LRP10 1934.0 5808.0
LRP12 1360.0 7900.0
LRP2 -392.0 6762.0
LRP5 5604.0 4248.0
LRP6 -1143.0 -3132.0
LRP8 -3317.0 8175.0
LRRC7 -2647.0 1172.0
LRRK2 9819.0 7567.0
LTB4R 9043.0 9911.0
LTB4R2 -4978.0 202.0
LYL1 6663.0 8727.0
LYN 8483.0 8583.0
LYPLA1 9717.0 9370.0
MAD1L1 -7970.0 -1024.0
MAD2L1 1415.0 -8573.0
MADD -10948.0 -8948.0
MAF1 2755.0 4348.0
MAGED1 -10150.0 -10551.0
MAML1 -2430.0 5472.0
MAML2 -1546.0 -1346.0
MAML3 7860.0 10038.0
MAMLD1 3618.0 -4081.0
MAP2K1 8861.0 10365.0
MAP2K2 4832.0 6767.0
MAP2K5 3289.0 6084.0
MAP3K11 5048.0 8330.0
MAP3K7 2469.0 7237.0
MAPK1 -1086.0 9427.0
MAPK11 8895.0 6888.0
MAPK12 5297.0 -5399.0
MAPK13 -7306.0 -466.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MAPK6 9102.0 9313.0
MAPK7 -9798.0 3379.0
MAPK8 -794.0 -7374.0
MAPKAP1 7373.0 6742.0
MAPKAPK2 -10648.0 4888.0
MAPKAPK3 7908.0 10021.0
MAPKAPK5 -2122.0 -4742.0
MAPRE1 9727.0 8182.0
MARK3 9015.0 9517.0
MATK -10976.0 -10513.0
MBD3 3015.0 -3753.0
MC1R -10499.0 -9166.0
MCF2 -4557.0 5961.0
MCF2L -3197.0 -8181.0
MCHR1 -4213.0 -5246.0
MDK 3574.0 -4317.0
MDM2 3788.0 6943.0
MECOM -9480.0 3550.0
MED1 -6238.0 727.0
MEF2A 8559.0 9073.0
MEF2C 5395.0 -197.0
MEF2D -9927.0 -3220.0
MEMO1 9973.0 10096.0
MEN1 -8958.0 -4079.0
METAP1 2716.0 -3781.0
METAP2 7450.0 2869.0
MFNG -5389.0 -4960.0
MGLL 5785.0 8910.0
MIB1 -4278.0 -6206.0
MIB2 -8918.0 -9157.0
MIR25 -9582.0 -5066.0
MIS12 -642.0 -9046.0
MKNK1 9615.0 8634.0
MKRN1 9667.0 8088.0
MKS1 -2784.0 -6106.0
MLST8 308.0 1090.0
MMP7 3865.0 6460.0
MMP9 8967.0 1371.0
MOB1A 9663.0 9528.0
MOB1B 9504.0 8546.0
MOV10 -8699.0 -9786.0
MRAS -10360.0 23.0
MRTFA 7162.0 9194.0
MST1 -7025.0 2970.0
MST1R -5128.0 -7481.0
MT-RNR2 -4826.0 4275.0
MTA1 1434.0 -1530.0
MTA2 -7881.0 118.0
MTA3 -6020.0 -3219.0
MTMR4 -6891.0 4594.0
MTOR -10624.0 -2672.0
MUC20 3464.0 -5169.0
MXD4 -10895.0 -8968.0
MYB 8064.0 1791.0
MYC 8955.0 225.0
MYD88 8926.0 8524.0
MYH10 -8290.0 -803.0
MYH11 4011.0 -6608.0
MYH9 -3200.0 7267.0
MYL12B 4418.0 5818.0
MYL6 8187.0 9600.0
MYL9 9168.0 8305.0
MYLIP -3400.0 -9301.0
MYLK 389.0 6003.0
MYO7A 9586.0 10328.0
MYO9A -7433.0 -2759.0
MYO9B -3670.0 7822.0
NAB1 8717.0 1890.0
NAB2 -9919.0 -7373.0
NAPEPLD -3285.0 -4720.0
NBEA -4379.0 -3720.0
NCAM1 -10869.0 -7309.0
NCBP1 2967.0 -1011.0
NCBP2 6179.0 -5809.0
NCF1 7986.0 3322.0
NCF2 10167.0 10265.0
NCF4 10090.0 10097.0
NCK1 -8084.0 -8497.0
NCK2 -5824.0 4434.0
NCKAP1 2316.0 10142.0
NCKAP1L 1901.0 10162.0
NCKIPSD 289.0 -2712.0
NCOA1 -3324.0 5089.0
NCOA2 -7260.0 1011.0
NCOA3 -2432.0 5828.0
NCOR1 -1531.0 9348.0
NCOR2 -2998.0 10117.0
NCSTN 9915.0 10361.0
NDC80 467.0 -9208.0
NDE1 -1037.0 -4670.0
NDEL1 7043.0 7825.0
NEDD4 -1574.0 7147.0
NEDD4L 4410.0 9142.0
NEDD8 5330.0 8439.0
NEFL 7064.0 -8252.0
NELFB -5387.0 1018.0
NET1 -7002.0 -4171.0
NEURL1 -11014.0 -8368.0
NEURL1B -8314.0 -576.0
NF1 -3172.0 5202.0
NF2 -9490.0 -6173.0
NFATC1 -9820.0 -3625.0
NFKB1 8527.0 5403.0
NFKBIA 8114.0 5809.0
NGFR -4332.0 -4135.0
NLK 1060.0 6044.0
NLN 9613.0 6880.0
NMB -2141.0 1432.0
NMT1 4695.0 7205.0
NMT2 -7414.0 -10461.0
NMUR1 -10894.0 -10268.0
NOG -6851.0 -10562.0
NOS3 7751.0 -4608.0
NOTCH1 -6741.0 1205.0
NOTCH2 1164.0 5400.0
NOTCH3 -7507.0 10318.0
NOTCH4 -10239.0 2947.0
NOXA1 -240.0 -6607.0
NPFFR1 7714.0 4384.0
NPHP4 -2216.0 909.0
NR1H2 4953.0 7742.0
NR1H3 -3942.0 -2012.0
NR3C1 -4556.0 1036.0
NR4A1 -8998.0 -8557.0
NRAS 8582.0 7708.0
NRG1 7105.0 -2454.0
NRG4 4405.0 4.0
NRIP1 2987.0 7453.0
NRP1 -7972.0 -5185.0
NRP2 -1731.0 -7406.0
NSL1 6576.0 7622.0
NSMAF 4365.0 538.0
NTRK1 -6360.0 -10587.0
NTSR1 10297.0 10497.0
NUDC 4281.0 1023.0
NUF2 2620.0 -2176.0
NUMB 10245.0 10465.0
NUP107 -8816.0 -8274.0
NUP133 -5348.0 776.0
NUP160 -2219.0 -8347.0
NUP37 5728.0 6078.0
NUP43 -3773.0 -8208.0
NUP85 2286.0 -2781.0
NUP98 -1200.0 2149.0
OBSCN -5036.0 -7803.0
OCRL 6438.0 9145.0
OFD1 -8209.0 -9654.0
OMG 7468.0 9017.0
OPHN1 -7829.0 1560.0
OPN3 6143.0 8164.0
OPRD1 -7245.0 144.0
OPRL1 5736.0 8334.0
OPRM1 6190.0 4645.0
OR10A6 5613.0 -1832.0
OR10AC1 1720.0 -5839.0
OR10G3 1738.0 7211.0
OR10H5 -890.0 -3109.0
OR14J1 -2235.0 -1287.0
OR14L1P 3719.0 2157.0
OR1A1 13.0 -1525.0
OR1D2 5468.0 537.0
OR1I1 4656.0 3398.0
OR1M1 -967.0 -5085.0
OR2A1 -7739.0 -5568.0
OR2A5 -2862.0 1528.0
OR2A7 -1066.0 -8982.0
OR2AT4 4372.0 2766.0
OR2B11 8191.0 5588.0
OR2C3 -59.0 7309.0
OR2G6 5261.0 -593.0
OR2H2 6280.0 -1290.0
OR2I1P 650.0 -8214.0
OR2L2 -7808.0 5837.0
OR2M3 5646.0 3337.0
OR2M4 7921.0 753.0
OR2T33 6716.0 5248.0
OR2V2 7905.0 1951.0
OR2W3 9183.0 7629.0
OR4D1 782.0 -9369.0
OR4D9 -2967.0 2864.0
OR4E1 1483.0 -2341.0
OR4K17 -5539.0 298.0
OR51L1 3906.0 2411.0
OR52A1 -4447.0 1169.0
OR52K1 7744.0 6859.0
OR52N4 -1681.0 -4503.0
OR56A1 6690.0 6496.0
OR5A1 -581.0 36.0
OR5A2 1835.0 -3389.0
OR5AN1 2140.0 -1405.0
OR5AS1 -5417.0 -2880.0
OR5AU1 2739.0 2805.0
OR6C75 7829.0 7177.0
OR6Y1 1302.0 2059.0
OR7A17 -3321.0 1178.0
OR7A5 -4786.0 -2598.0
OR7C1 -3654.0 6325.0
OR7D2 -6497.0 4255.0
OR8A1 6286.0 5188.0
OS9 9572.0 10053.0
OTUD3 -6876.0 -7502.0
OTUD7B -10613.0 -10397.0
OTULIN -4985.0 93.0
OXER1 6820.0 5231.0
OXTR -8162.0 3603.0
P2RY1 -7831.0 10440.0
P2RY10 -9982.0 -10038.0
P2RY11 -8087.0 -9630.0
P2RY12 -1550.0 5827.0
P2RY13 9434.0 8706.0
P2RY14 -7308.0 -10625.0
P2RY2 6995.0 6260.0
P2RY6 -6306.0 -8918.0
P4HB 8507.0 9962.0
PAFAH1B1 491.0 7762.0
PAG1 1967.0 6079.0
PAK1 10129.0 7653.0
PAK2 9098.0 8874.0
PAK3 -1475.0 -334.0
PAQR3 -2104.0 2044.0
PARD3 1359.0 8517.0
PARD6A -4778.0 -2743.0
PARP1 -10265.0 -8043.0
PBX1 -4201.0 4426.0
PCP2 -5798.0 -2981.0
PCSK5 1198.0 7008.0
PCSK6 8733.0 9709.0
PDE11A 4051.0 3674.0
PDE1B 4828.0 8012.0
PDE2A -8555.0 -3776.0
PDE3A 5217.0 7642.0
PDE3B -9089.0 -10606.0
PDE4A -6406.0 901.0
PDE4B 2350.0 -6105.0
PDE4C 5384.0 5215.0
PDE4D -8570.0 4695.0
PDE6A 6016.0 -3492.0
PDE6B -6546.0 -9087.0
PDE6D 4393.0 7441.0
PDE6G -9120.0 3276.0
PDE7A -5641.0 -10008.0
PDE7B -5624.0 3162.0
PDE8A -7927.0 1262.0
PDE8B -8632.0 730.0
PDGFA 1176.0 5657.0
PDGFB -8368.0 -7863.0
PDGFC 109.0 4670.0
PDGFD -10930.0 -8800.0
PDGFRA -825.0 7909.0
PDGFRB -10542.0 -8788.0
PDHA1 1603.0 3183.0
PDHB 8732.0 5499.0
PDHX 9405.0 5798.0
PDK1 7585.0 1755.0
PDK2 -8421.0 -6309.0
PDK3 -3793.0 2930.0
PDK4 6383.0 8816.0
PDPK1 -54.0 8056.0
PEA15 3001.0 -5301.0
PEBP1 -3719.0 -9443.0
PELP1 -2643.0 -9040.0
PF4 3055.0 6229.0
PFN1 1471.0 6861.0
PFN2 5228.0 1718.0
PGF -9085.0 -3495.0
PHB 4244.0 -2118.0
PHC1 -5740.0 -6201.0
PHC2 8347.0 10344.0
PHC3 -5903.0 -5109.0
PHLPP1 -10161.0 2750.0
PHLPP2 -10743.0 -9576.0
PIK3AP1 7061.0 8941.0
PIK3C3 4588.0 3248.0
PIK3CA 5168.0 6821.0
PIK3CB 9880.0 9707.0
PIK3CD -932.0 3422.0
PIK3CG -9133.0 3842.0
PIK3R1 -7314.0 -9108.0
PIK3R2 2369.0 6022.0
PIK3R3 -10971.0 -7175.0
PIK3R4 -624.0 -83.0
PIK3R5 -10408.0 -5867.0
PIK3R6 6288.0 8699.0
PIN1 -6018.0 434.0
PIP4K2A -8550.0 3142.0
PIP4K2B -7834.0 -2440.0
PIP4K2C -10333.0 -5556.0
PIP5K1A 7643.0 7381.0
PIP5K1B 3569.0 6574.0
PIP5K1C -4414.0 4334.0
PKN1 -10152.0 280.0
PKN2 2415.0 -1844.0
PKN3 -4357.0 2867.0
PLA2G4A 10226.0 10618.0
PLAT 5536.0 -2047.0
PLB1 10170.0 10628.0
PLCB1 -5094.0 -886.0
PLCB2 3198.0 5575.0
PLCB3 8119.0 10471.0
PLCG1 -5836.0 -10187.0
PLCG2 -6227.0 6708.0
PLEKHG2 2976.0 9540.0
PLEKHG5 1.0 -10180.0
PLG 299.0 -2400.0
PLIN1 -6520.0 3635.0
PLK1 3226.0 4831.0
PLPPR2 9375.0 9347.0
PLPPR3 3994.0 1075.0
PLTP 581.0 9199.0
PLXNB1 1702.0 4944.0
PLXND1 4753.0 8202.0
PMEPA1 -4668.0 -8211.0
PMF1 4771.0 1854.0
PML -917.0 -9991.0
PNOC -4536.0 -2077.0
POFUT1 -1544.0 2314.0
POGLUT1 -8242.0 -2925.0
POLR2A -9475.0 -260.0
POLR2B 296.0 2423.0
POLR2C 3736.0 -612.0
POLR2D 6248.0 -1802.0
POLR2E 8013.0 8218.0
POLR2F 320.0 5451.0
POLR2G 1642.0 5704.0
POLR2H 4812.0 -2703.0
POLR2I 2083.0 1475.0
POLR2J 7302.0 8189.0
POLR2K 7511.0 2990.0
POLR2L 2955.0 6234.0
POMC 2426.0 -2728.0
PORCN -8837.0 -7524.0
POU2F1 -4769.0 4835.0
PPARD -2980.0 -6109.0
PPARG 10358.0 10670.0
PPBP 5440.0 6001.0
PPEF1 3791.0 -4967.0
PPID 9049.0 5586.0
PPM1A 6500.0 7841.0
PPP1CA 1299.0 5236.0
PPP1CB 8424.0 7913.0
PPP1CC 9534.0 8032.0
PPP1R12A 4370.0 6838.0
PPP1R12B -9386.0 -1700.0
PPP1R14A 6866.0 7570.0
PPP1R15A 8269.0 4866.0
PPP2CA 9766.0 8577.0
PPP2CB 9136.0 9093.0
PPP2R1A 1997.0 5379.0
PPP2R1B 3691.0 1706.0
PPP2R5A -3440.0 4169.0
PPP2R5B 4569.0 7252.0
PPP2R5C -9892.0 -8496.0
PPP2R5D -5620.0 3209.0
PPP2R5E 522.0 2302.0
PPP3CA 3489.0 7766.0
PPP3CB 9261.0 8237.0
PPP3CC -10514.0 -9849.0
PPP3R1 8749.0 9050.0
PPP5C -8001.0 530.0
PRC1 164.0 4943.0
PRDM4 -8166.0 -3952.0
PREX1 -8025.0 8057.0
PRICKLE1 3999.0 4587.0
PRKAA1 2546.0 5143.0
PRKAB1 -458.0 4538.0
PRKAB2 -6078.0 -3690.0
PRKACA 9995.0 10558.0
PRKACB -8479.0 -10448.0
PRKAG1 7411.0 7976.0
PRKAG2 7267.0 1382.0
PRKAR1A 8904.0 9754.0
PRKAR1B 7778.0 8646.0
PRKAR2A 1151.0 7558.0
PRKAR2B 4069.0 6461.0
PRKCA 2691.0 1966.0
PRKCB -4906.0 9024.0
PRKCD 9710.0 9721.0
PRKCE -10688.0 -925.0
PRKCH -10885.0 -10674.0
PRKCI 5581.0 4076.0
PRKCQ -9967.0 -10691.0
PRKCZ -10726.0 -9780.0
PRKG1 6638.0 5530.0
PRKG2 -7286.0 -6385.0
PRKX -4033.0 -8552.0
PRMT1 -2286.0 -7224.0
PROK2 8528.0 9009.0
PRR5 -10901.0 -10359.0
PSAP 8066.0 8239.0
PSEN1 7406.0 9055.0
PSEN2 -2616.0 -7755.0
PSENEN 8280.0 7751.0
PSMA1 9165.0 8953.0
PSMA2 9175.0 6486.0
PSMA3 8811.0 -3545.0
PSMA4 8595.0 258.0
PSMA5 6009.0 -5256.0
PSMA6 9365.0 6915.0
PSMA7 6006.0 7700.0
PSMB1 8548.0 3242.0
PSMB10 -972.0 -8733.0
PSMB2 8065.0 5797.0
PSMB3 8817.0 8326.0
PSMB4 4018.0 3039.0
PSMB5 8225.0 9508.0
PSMB6 6959.0 8991.0
PSMB7 9346.0 8950.0
PSMB8 5148.0 -5793.0
PSMB9 -5133.0 -10716.0
PSMC1 7220.0 8544.0
PSMC2 4967.0 6378.0
PSMC3 2824.0 4673.0
PSMC4 -9365.0 -3210.0
PSMC5 2913.0 2050.0
PSMC6 9832.0 7978.0
PSMD1 8509.0 8974.0
PSMD10 6347.0 2957.0
PSMD11 8697.0 9183.0
PSMD12 9648.0 8351.0
PSMD13 7185.0 6511.0
PSMD14 7985.0 5632.0
PSMD2 7347.0 8049.0
PSMD3 3057.0 6067.0
PSMD4 8627.0 9334.0
PSMD5 1520.0 8328.0
PSMD6 9864.0 9375.0
PSMD7 9212.0 6772.0
PSMD8 6905.0 6585.0
PSMD9 7407.0 8869.0
PSME1 -1137.0 -9489.0
PSME2 3614.0 -10267.0
PSME3 9544.0 8452.0
PSME4 -8419.0 -464.0
PSMF1 7685.0 5740.0
PSPN 6888.0 928.0
PTAFR 10084.0 10562.0
PTBP1 -753.0 1627.0
PTCH1 -10820.0 -9766.0
PTCH2 -992.0 -6798.0
PTCRA 4612.0 8572.0
PTEN 8668.0 9329.0
PTENP1 -1818.0 -4756.0
PTGDR -11008.0 -10143.0
PTGDR2 -10228.0 -10135.0
PTGER2 4914.0 -851.0
PTGER3 8045.0 -4326.0
PTGER4 -10396.0 -9272.0
PTGES3 9517.0 4303.0
PTGFR 9940.0 9641.0
PTGIR -5450.0 -8455.0
PTK2 4992.0 3213.0
PTK2B 2160.0 9588.0
PTK6 7972.0 8367.0
PTPN1 -7223.0 8628.0
PTPN11 3471.0 9688.0
PTPN12 6377.0 9874.0
PTPN18 -3234.0 9001.0
PTPN2 8577.0 10537.0
PTPN3 -1234.0 2091.0
PTPN6 3230.0 7923.0
PTPN7 -8688.0 -7879.0
PTPRA -9952.0 4769.0
PTPRJ 1010.0 9383.0
PTPRK -8535.0 -6991.0
PTPRO 5327.0 6304.0
PTPRS -10959.0 -8229.0
PTPRU 415.0 -1928.0
PXN -1154.0 6730.0
PYGO2 -8926.0 -8200.0
QRFP -6983.0 2982.0
RAB4A 8673.0 6735.0
RAB4B -3971.0 4641.0
RAB6A 8383.0 9332.0
RAC1 9345.0 9946.0
RAC2 -1305.0 4460.0
RAC3 -67.0 -1887.0
RACGAP1 4139.0 4294.0
RACK1 4364.0 292.0
RAD21 2777.0 1005.0
RAF1 8083.0 7846.0
RAG1 -10667.0 -8657.0
RALA 8746.0 2764.0
RALB 9778.0 8653.0
RALBP1 3474.0 6850.0
RALGDS -10755.0 -9889.0
RAMP1 -10861.0 -4789.0
RANBP10 -4299.0 3329.0
RANBP2 457.0 512.0
RANBP9 802.0 6559.0
RANGAP1 -9450.0 -10158.0
RAP1A 9691.0 8186.0
RAP1B -3254.0 7324.0
RAPGEF1 -10785.0 -4187.0
RAPGEF2 5158.0 7949.0
RAPGEF3 -5747.0 5214.0
RARA -2636.0 7214.0
RARG 2804.0 -2920.0
RASA1 -703.0 7613.0
RASA2 -7886.0 -3395.0
RASA3 -10081.0 -10027.0
RASA4 -8600.0 -10090.0
RASAL1 -3649.0 3963.0
RASAL2 -7035.0 2676.0
RASAL3 -10386.0 -10650.0
RASGEF1A -10682.0 -2489.0
RASGRF1 -7882.0 3486.0
RASGRF2 -3266.0 -10157.0
RASGRP1 -9188.0 -10645.0
RASGRP2 -6869.0 -9348.0
RASGRP3 -4802.0 -9325.0
RASGRP4 10117.0 10286.0
RBBP4 4490.0 4905.0
RBBP5 1478.0 542.0
RBBP7 -9908.0 -7503.0
RBCK1 -2937.0 632.0
RBFOX2 -6643.0 -4561.0
RBL1 -7439.0 -5561.0
RBPJ 9553.0 10058.0
RBX1 1119.0 4750.0
RCC2 -8202.0 -3569.0
RCE1 -3223.0 -1780.0
RCOR1 9761.0 9880.0
RCVRN 6600.0 8091.0
RDH10 -9710.0 -4803.0
RDH11 3639.0 6991.0
RDH13 -5554.0 -8280.0
RDH14 -6198.0 -8313.0
RDH16 -3445.0 -5570.0
RDH5 8386.0 1337.0
REEP2 -4622.0 -4739.0
REEP3 8275.0 8925.0
REEP4 8730.0 10244.0
REEP5 9241.0 7897.0
REEP6 -6069.0 -9189.0
RELA -2847.0 -1359.0
REST -3978.0 3460.0
RET -9977.0 -5365.0
RETSAT -2295.0 -1561.0
RFNG 5961.0 8156.0
RGL1 9370.0 9936.0
RGL2 4449.0 9300.0
RGL3 9529.0 7778.0
RGR -6948.0 6002.0
RGS1 2355.0 -4667.0
RGS10 3776.0 4045.0
RGS12 -9943.0 -8179.0
RGS14 5153.0 3335.0
RGS16 10290.0 3366.0
RGS17 -2383.0 3976.0
RGS18 5989.0 6993.0
RGS19 7693.0 7150.0
RGS2 7786.0 9212.0
RGS3 -8446.0 1615.0
RGS5 -8413.0 -4297.0
RGS6 840.0 6036.0
RGS9 -9942.0 -8270.0
RHEB 9612.0 9099.0
RHOA 9541.0 9090.0
RHOB -6176.0 416.0
RHOBTB1 3779.0 7862.0
RHOBTB2 -6712.0 -1085.0
RHOC -11013.0 -4671.0
RHOF -10845.0 -10601.0
RHOG 8649.0 8946.0
RHOH -4340.0 -9248.0
RHOQ 10030.0 8943.0
RHOT1 10236.0 10427.0
RHOT2 -2497.0 -4705.0
RHOU 9641.0 10458.0
RHPN1 5442.0 -6957.0
RHPN2 -102.0 430.0
RICTOR -7204.0 -8306.0
RING1 -1586.0 -738.0
RIPK1 -8110.0 -7415.0
RIPK2 8675.0 2009.0
RIT1 9776.0 10016.0
RLN2 -596.0 -6146.0
RLN3 -4997.0 8709.0
RNF111 4248.0 6346.0
RNF146 6563.0 10456.0
RNF2 5504.0 4715.0
RNF31 -7411.0 -10095.0
RNF41 6643.0 9620.0
RNF43 -9954.0 -10713.0
ROCK1 5871.0 8890.0
ROCK2 2896.0 8362.0
ROR1 -854.0 2172.0
RPGRIP1L -3980.0 -10044.0
RPS27 -7168.0 -6878.0
RPS27A -1868.0 -5386.0
RPS6 2176.0 -3737.0
RPS6KA1 1245.0 8996.0
RPS6KA2 -5842.0 2331.0
RPS6KA3 1034.0 3942.0
RPS6KA5 70.0 -10393.0
RPS6KB1 6945.0 -365.0
RPS6KB2 1743.0 379.0
RPTOR -10446.0 -7646.0
RRAGA 3684.0 7518.0
RRAGB 4552.0 1455.0
RRAGC 7966.0 4974.0
RRAGD 9956.0 9097.0
RRH -1810.0 -7145.0
RTKN -10646.0 -10355.0
RTN4 9858.0 10071.0
RTP4 -2976.0 -9549.0
RTP5 -6351.0 -6918.0
RUNX1 6393.0 8481.0
RUNX3 -11023.0 -10682.0
RUVBL1 1938.0 -4991.0
RXFP2 8774.0 9074.0
RXFP4 -4064.0 -3311.0
RXRA 6389.0 8760.0
RXRB -2481.0 479.0
RYK -1034.0 -7124.0
S100A8 10362.0 10564.0
S100A9 10316.0 10598.0
S100B -10129.0 814.0
S1PR1 -10247.0 -7325.0
S1PR2 -9355.0 -9683.0
S1PR3 8719.0 -1284.0
S1PR4 -6425.0 578.0
S1PR5 -11033.0 -10604.0
SAG 1518.0 4431.0
SALL4 -9304.0 2226.0
SAV1 -3845.0 2150.0
SCAI 146.0 -7095.0
SCD 4702.0 3606.0
SCMH1 3592.0 -4122.0
SCRIB -8883.0 -1661.0
SCT -9440.0 -8419.0
SCUBE2 -3086.0 -1143.0
SDC2 6034.0 5778.0
SDC3 8050.0 -2699.0
SDC4 7546.0 7624.0
SEC13 6324.0 5321.0
SEH1L 8372.0 -4799.0
SEL1L 6263.0 8390.0
SEM1 5210.0 6938.0
SEPTIN7 -3735.0 4359.0
SERPINE1 3011.0 7764.0
SFN 4316.0 -5611.0
SFPQ 6274.0 2084.0
SGK1 8332.0 -90.0
SGO1 -6022.0 -1969.0
SGO2 731.0 -2100.0
SH2B1 -3893.0 -6025.0
SH2B2 2514.0 9954.0
SH2B3 -65.0 4784.0
SH2D2A -10864.0 -10426.0
SH3GL1 6353.0 8238.0
SH3KBP1 2654.0 6905.0
SHARPIN -209.0 5506.0
SHB -4040.0 6202.0
SHC1 3101.0 5292.0
SHC3 9069.0 -1064.0
SHOC2 7882.0 8016.0
SIRT6 5059.0 8401.0
SKA1 3090.0 2476.0
SKA2 -3633.0 -962.0
SKI -10363.0 -10605.0
SKIL -7360.0 2902.0
SKP1 8911.0 4204.0
SLC24A1 -8756.0 -3911.0
SLC38A9 4803.0 6070.0
SMAD1 4734.0 10482.0
SMAD2 1682.0 7725.0
SMAD3 -10166.0 -9199.0
SMAD4 -3390.0 -7669.0
SMAD5 -2406.0 329.0
SMAD6 6361.0 7463.0
SMAD7 -10989.0 -9842.0
SMAD9 5973.0 -2792.0
SMARCA4 -4137.0 8319.0
SMC1A -2067.0 3659.0
SMC3 6125.0 -761.0
SMPD2 -4755.0 5874.0
SMPD3 -10029.0 -9933.0
SMURF1 -8349.0 1131.0
SMURF2 -9485.0 -7896.0
SNAI1 7978.0 9924.0
SNW1 8504.0 6624.0
SNX3 10083.0 10139.0
SOCS1 8467.0 6659.0
SOCS3 10312.0 10656.0
SOCS6 8062.0 10245.0
SORCS3 3371.0 -4889.0
SOS1 2394.0 -4661.0
SOS2 8073.0 8815.0
SOX13 -10529.0 -10434.0
SOX4 -3610.0 5979.0
SOX6 7586.0 3610.0
SOX7 4163.0 -5090.0
SP1 6728.0 9578.0
SPARC 7330.0 7225.0
SPC24 -1695.0 1570.0
SPDL1 -7000.0 -6193.0
SPHK1 8695.0 8421.0
SPINT1 8074.0 9078.0
SPINT2 8306.0 8806.0
SPOP 5997.0 -256.0
SPOPL 9066.0 9067.0
SPPL2A 9457.0 7508.0
SPPL2B -2826.0 -5096.0
SPRED1 -8378.0 -3713.0
SPRED2 -2639.0 8478.0
SPRED3 -3150.0 -3741.0
SPRY1 -4758.0 1080.0
SPRY2 -8767.0 514.0
SPTA1 9220.0 7274.0
SPTAN1 -10045.0 -9563.0
SPTB 9406.0 9121.0
SPTBN1 -8781.0 -6351.0
SPTBN2 -6201.0 -2780.0
SPTBN5 -7032.0 -3485.0
SQSTM1 5451.0 -188.0
SRC -4936.0 -8846.0
SREBF1 8706.0 1961.0
SRF 4327.0 6929.0
SRGAP1 1553.0 8311.0
SRGAP2 1287.0 9011.0
SRGAP3 -8233.0 -2515.0
SSTR2 5813.0 -25.0
SSTR3 -7936.0 -8389.0
ST3GAL3 -1028.0 2393.0
ST3GAL4 -9447.0 4972.0
ST3GAL6 9322.0 5613.0
STAG1 -5124.0 -2431.0
STAG2 6585.0 5209.0
STAM 2880.0 1495.0
STAM2 8313.0 7133.0
STAP2 4431.0 -8904.0
STARD13 -7331.0 7370.0
STARD8 765.0 2229.0
STAT1 -3982.0 -10718.0
STAT3 9401.0 8593.0
STAT5A 8323.0 7832.0
STAT5B 4680.0 4956.0
STAT6 195.0 7872.0
STK11 888.0 -956.0
STK3 10125.0 9767.0
STK4 -6343.0 3125.0
STMN1 -3862.0 -6746.0
STRADA -363.0 2802.0
STRADB 9927.0 8176.0
STRAP 9423.0 7098.0
STRN -4503.0 6601.0
STUB1 -5098.0 -1439.0
SUCNR1 8841.0 5124.0
SUFU 5412.0 10345.0
SUZ12 4242.0 493.0
SYDE2 6023.0 -5682.0
SYK 9750.0 10350.0
SYNGAP1 -8010.0 -6580.0
SYVN1 25.0 3387.0
TAB1 7080.0 3716.0
TAB2 8556.0 6836.0
TAB3 215.0 4794.0
TACC3 10241.0 9886.0
TACR2 -261.0 3124.0
TAGAP -9096.0 -10699.0
TAOK1 1183.0 7833.0
TAS1R3 -2955.0 -8464.0
TAS2R14 5447.0 2884.0
TAS2R20 1511.0 -1730.0
TAS2R3 -7037.0 -6295.0
TAS2R30 -912.0 -1905.0
TAS2R4 598.0 -4136.0
TAS2R5 -5295.0 -5798.0
TAX1BP1 7589.0 7124.0
TAX1BP3 6816.0 8304.0
TBL1X 6931.0 7717.0
TBL1XR1 5299.0 5430.0
TBP -307.0 -4592.0
TBXA2R -1679.0 4971.0
TCF12 -3191.0 6334.0
TCF4 -9375.0 4480.0
TCF7 -1318.0 -10472.0
TCF7L1 4593.0 702.0
TCF7L2 -10234.0 -870.0
TCIRG1 253.0 9871.0
TEC 6790.0 9842.0
TERT 6249.0 -2529.0
TF 2007.0 3922.0
TFDP1 9979.0 8001.0
TFDP2 -10993.0 -10675.0
TGFA 5895.0 9650.0
TGFB1 984.0 3574.0
TGFBR1 -7710.0 -1431.0
TGFBR2 -6958.0 4321.0
TGIF1 -3664.0 -5115.0
TGIF2 -5602.0 -7512.0
THBS1 1255.0 9820.0
THBS3 9211.0 8379.0
THBS4 -1756.0 -6936.0
THEM4 -1580.0 -10466.0
TIA1 1543.0 -2965.0
TIAL1 6466.0 1156.0
TIAM1 3669.0 -4480.0
TIAM2 -9556.0 -9322.0
TJP1 -85.0 -2268.0
TJP2 1843.0 -688.0
TLE1 -10914.0 -988.0
TLE2 1757.0 -9540.0
TLE3 4969.0 9777.0
TLE4 -1783.0 7260.0
TLE5 -10323.0 -9697.0
TLN1 5974.0 9916.0
TLR9 -10559.0 -4710.0
TMED2 6691.0 7410.0
TMED5 8614.0 8378.0
TNF 855.0 -8625.0
TNFAIP3 -10143.0 -6698.0
TNFRSF10A 4118.0 3119.0
TNFRSF10B 9743.0 6094.0
TNFRSF10D 10327.0 9907.0
TNFRSF1A 10046.0 10283.0
TNFSF10 9924.0 -1909.0
TNKS -8859.0 -2898.0
TNKS2 642.0 4031.0
TNRC6A -4886.0 798.0
TNRC6B -9496.0 -1984.0
TNRC6C -10483.0 -10508.0
TNS3 10126.0 10220.0
TNS4 -851.0 1590.0
TP53 -5246.0 -8954.0
TPH1 4060.0 -6005.0
TRADD 7677.0 -7288.0
TRAF1 -8006.0 -10334.0
TRAF2 -7822.0 -10338.0
TRAF6 -4471.0 1582.0
TRAT1 6974.0 -9441.0
TRIB1 6930.0 8686.0
TRIB3 -7114.0 -4878.0
TRIM27 9100.0 8140.0
TRIM33 -6992.0 -4229.0
TRIO -9022.0 3620.0
TRIP10 2447.0 2170.0
TRPC3 -8356.0 -765.0
TRPC6 -7554.0 2174.0
TRRAP -9540.0 -2608.0
TSC1 -5608.0 223.0
TSC2 -2640.0 -1107.0
TSHR 4971.0 -932.0
TTC21B -9805.0 -7396.0
TULP3 -9731.0 -9383.0
TYK2 4043.0 8696.0
UBA52 2067.0 260.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2D1 10262.0 10093.0
UBE2D3 9631.0 8934.0
UBE2M 3363.0 8550.0
UCHL5 3830.0 -4523.0
UCN -4422.0 -2288.0
UHMK1 -4370.0 588.0
USF1 6088.0 6846.0
USF2 2798.0 7594.0
USP13 -7140.0 -215.0
USP15 7488.0 4692.0
USP21 -1984.0 -3521.0
USP34 -6599.0 1766.0
USP4 7575.0 8759.0
USP7 -171.0 8779.0
USP8 8356.0 8962.0
USP9X 1306.0 5792.0
UTS2 -7792.0 2429.0
UTS2B -7910.0 1740.0
VAPA 9859.0 9626.0
VAV1 6299.0 7892.0
VAV2 -9043.0 2054.0
VAV3 -7486.0 7780.0
VCL 913.0 8321.0
VCP 7591.0 6702.0
VEGFA 7943.0 7054.0
VEGFB -4813.0 -5745.0
VIPR1 -1716.0 -3811.0
VIPR2 -10941.0 -9130.0
VPS26A 8363.0 9013.0
VPS29 8945.0 7867.0
VPS35 8998.0 7750.0
VRK3 -2450.0 3426.0
VWF 3995.0 7559.0
WAS 9521.0 9854.0
WASF1 10267.0 10673.0
WASF2 6329.0 9933.0
WASF3 5357.0 6353.0
WASL -3272.0 1473.0
WDR19 -3157.0 -6032.0
WDR35 -7722.0 -4975.0
WDR83 2175.0 4833.0
WIPF1 -7238.0 -2901.0
WIPF2 1332.0 7562.0
WLS 9315.0 6920.0
WNT1 -3512.0 -10122.0
WNT10A -4285.0 -7630.0
WNT10B -5833.0 -9007.0
WNT11 9163.0 10391.0
WNT16 -7965.0 1775.0
WNT2B -5914.0 2351.0
WNT3 -8068.0 4819.0
WNT4 -3932.0 -2693.0
WNT5B -9445.0 4846.0
WNT6 5040.0 6674.0
WNT7A 4536.0 -10292.0
WNT8B 2530.0 -3062.0
WNT9A -3374.0 -1748.0
WNT9B -6700.0 2571.0
WWC1 730.0 1676.0
WWOX -10546.0 -6071.0
WWP1 333.0 -9676.0
WWP2 7878.0 8513.0
WWTR1 -6390.0 -5777.0
XCL1 -7908.0 -6491.0
XCL2 -10340.0 -10077.0
XCR1 -10362.0 7894.0
XIAP 2637.0 2732.0
XK 9983.0 10452.0
XPO1 7772.0 4672.0
YBX1 -2475.0 4042.0
YES1 -10892.0 -9337.0
YWHAB 9116.0 6191.0
YWHAE 10079.0 10158.0
YWHAG 9489.0 10473.0
YWHAH 9385.0 9379.0
YWHAQ -6372.0 -2552.0
YWHAZ 7112.0 6341.0
YY1 -5236.0 -1577.0
ZDHHC21 -2854.0 -3157.0
ZDHHC7 9396.0 8985.0
ZDHHC9 9607.0 9743.0
ZFYVE16 8576.0 8989.0
ZFYVE9 -5444.0 -6753.0
ZNF217 3020.0 6457.0
ZNRF3 -913.0 -5811.0
ZRANB1 3511.0 -64.0
ZW10 4728.0 3709.0
ZWILCH -9008.0 -8767.0
ZWINT 131.0 -6302.0



FCGR activation

FCGR activation
metric value
setSize 75
pMANOVA 8.3e-23
p.adjustMANOVA 9.58e-21
s.dist 0.494
s.low.CRP 0.0799
s.high.CRP -0.488
p.low.CRP 0.231
p.high.CRP 2.73e-13




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD247 -10994 -10515
CD3G -8283 -10568
FCGR1A 10365 10249
FCGR2A 9647 9000
FCGR3A -11031 -7169
FGR 7776 10127
FYN -10683 -7016
HCK 10073 9850
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
LYN 8483 8583
SRC -4936 -8846
SYK 9750 10350
YES1 -10892 -9337



Creation of C4 and C2 activators

Creation of C4 and C2 activators
metric value
setSize 70
pMANOVA 8.44e-23
p.adjustMANOVA 9.58e-21
s.dist 0.497
s.low.CRP 0.112
s.high.CRP -0.484
p.low.CRP 0.106
p.high.CRP 2.41e-12




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
C1QA 2730 7449
C1QB 7676 9366
C1QC 8977 9784
C1R -9046 -4725
C1S -1133 4982
FCN1 10313 9522
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
MASP2 836 -2977



Initial triggering of complement

Initial triggering of complement
metric value
setSize 77
pMANOVA 1.26e-22
p.adjustMANOVA 1.32e-20
s.dist 0.471
s.low.CRP 0.109
s.high.CRP -0.458
p.low.CRP 0.0993
p.high.CRP 3.62e-12




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
C1QA 2730 7449
C1QB 7676 9366
C1QC 8977 9784
C1R -9046 -4725
C1S -1133 4982
C2 9215 6100
C3 -10957 -10571
C4A 6469 1331
C4B 3894 -2194
CFB 4527 1298
CFD 911 -342
FCN1 10313 9522
GZMM -10508 -10275
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
MASP2 836 -2977



Post-translational protein modification

Post-translational protein modification
metric value
setSize 1183
pMANOVA 1.18e-21
p.adjustMANOVA 1.15e-19
s.dist 0.208
s.low.CRP 0.126
s.high.CRP 0.166
p.low.CRP 2.77e-13
p.high.CRP 6.39e-22




Top 20 genes
Gene low CRP high CRP
PPARG 10358 10670
FAM20A 10342 10679
ADAMTS2 10314 10665
SOCS3 10312 10656
CTSA 10310 10636
VCAN 10280 10667
F5 10339 10599
NPL 10251 10671
FBXO9 10306 10429
RAB13 10172 10518
BST1 10348 10335
RHOT1 10236 10427
ASGR2 9976 10675
VNN1 10163 10414
FAM20C 10013 10541
RAB32 10118 10403
SERPINA1 10186 10295
FSTL3 9917 10500
ARF4 10147 10254
FBXL5 10325 10075

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAAS -4220 -2848
ACTB 10142 9915
ACTL6A 644 -1140
ACTR10 9447 8995
ACTR1A 1291 7735
ACTR5 -8300 -8488
ACTR8 -9028 1290
ADAM10 9652 10284
ADAMTS1 -10925 -6738
ADAMTS10 -10554 -9120
ADAMTS13 -717 -2609
ADAMTS14 -9572 -7264
ADAMTS16 -5486 -6100
ADAMTS17 1716 -5751
ADAMTS2 10314 10665
ADAMTS4 -9692 -8176
ADAMTS5 1277 -7082
ADAMTS6 -8817 -299
ADAMTSL3 -1249 -436
ADAMTSL4 8696 8969
ADAMTSL5 1742 -9869
ADRB2 -10762 -9843
ADRM1 338 3615
AGBL2 -7394 -7194
AGBL3 -2844 -8651
AGBL5 3831 3775
AGTPBP1 9472 9538
ALB 5157 1598
ALG1 -7518 -4565
ALG10 -9295 -2926
ALG10B 2640 -6554
ALG11 -4114 415
ALG12 -1788 -1158
ALG13 1354 -7430
ALG14 9158 8578
ALG2 6463 2704
ALG3 5995 -2482
ALG5 7403 2248
ALG6 7443 7333
ALG8 7380 705
ALG9 -3668 -3824
ALPL 8001 9349
AMDHD2 -10379 -9214
AMFR 9169 6554
ANK1 9056 9344
ANK3 5423 -4595
ANKRD28 -8321 -2586
ANKRD9 4178 7756
ANO8 3927 6336
APC -2802 3982
APLP2 9754 10588
APOA2 7224 7075
APOE -4921 3265
APOL1 1106 -9021
APP 10085 9961
AR -1905 4565
ARCN1 4291 7676
AREG -5505 9162
ARF1 9085 10196
ARF3 7124 9257
ARF4 10147 10254
ARF5 8080 9476
ARFGAP1 -2066 -296
ARFGAP2 -7117 -3644
ARFGAP3 2322 4136
ARRB1 -5720 3058
ARRB2 8232 9058
ARSA 6282 1069
ARSB 8290 9046
ARSD 7388 8269
ARSG -4 -7971
ARSJ -5813 -6407
ARSK -7489 -9464
ASB1 -7836 6220
ASB13 1661 1645
ASB14 762 662
ASB16 -4955 -2085
ASB2 -10383 -9299
ASB3 5783 4906
ASB4 -5402 -5291
ASB6 -7850 -4746
ASB7 5499 6321
ASB8 2931 5919
ASB9 1599 714
ASGR1 10213 10074
ASGR2 9976 10675
ASXL1 -6154 -8199
ASXL2 -4942 4265
ATXN3 5363 2787
ATXN7 5967 -2684
AURKA 3460 4836
AURKB 720 709
AXIN1 -10501 -8999
AXIN2 2553 -7267
B3GALNT2 4426 1998
B3GLCT -10293 -8087
B3GNT2 6491 4534
B3GNT4 -3531 -9653
B3GNT5 10268 8681
B3GNT7 -10766 -10193
B3GNT8 9784 9012
B3GNT9 5206 -9789
B3GNTL1 5069 5996
B4GALNT2 -4045 2852
B4GALT1 -3872 6820
B4GALT2 -2272 31
B4GALT3 -7395 -8398
B4GALT4 -6517 3566
B4GALT5 9525 9637
B4GALT6 -10803 131
B4GAT1 -1787 -2379
BABAM1 -493 1445
BAP1 -8951 1556
BARD1 -9066 -710
BCL10 6535 3786
BECN1 8030 6913
BET1 6957 1985
BET1L -4965 -5604
BGLAP 4253 -2208
BIRC2 8116 2944
BIRC3 2030 -10298
BIRC5 5078 5144
BLM 2729 -1602
BMI1 -1361 -6301
BRCA1 4641 7113
BRCC3 8635 8909
BST1 10348 10335
BTBD1 6779 3894
BTBD6 -7180 -3405
BTRC -7062 1812
C1GALT1 5940 -6509
C1GALT1C1 9935 9105
C3 -10957 -10571
C4A 6469 1331
CALM1 -4337 1051
CALR 8310 6954
CALU 8618 9731
CAMKMT 4722 4211
CAND1 1355 -1576
CANX 7507 7257
CAPZA1 9332 9316
CAPZA2 10077 9039
CAPZB 8393 8843
CASP8AP2 -5179 -8795
CBX2 -8946 -3592
CBX4 -8089 61
CBX5 -5063 -7545
CBX8 2677 6583
CCDC22 3107 8147
CCDC8 5122 -329
CCNA1 2520 -2665
CCNA2 3177 2827
CCNF -9341 -8844
CCP110 3033 4396
CD109 6898 6560
CD52 -1180 -2842
CD55 9747 10312
CD59 6386 4199
CDC20 3581 3590
CDC25A 4343 4765
CDC34 7794 8739
CDC73 5260 6248
CDCA8 -1406 -3171
CDK1 7292 -2497
CDKN2A -4195 308
CETN2 7674 6463
CFP 8398 8912
CHD3 -9906 -8152
CHM 3048 6845
CHML 1075 374
CHST10 -10642 -7986
CHST8 189 6510
CISH 9949 -655
CKAP4 10349 9973
CLSPN 5905 4810
CMAS 9980 10161
CNIH1 9266 8825
CNIH2 2506 2667
CNIH3 -9428 -8506
COG1 -9533 -9241
COG2 3963 1728
COG3 3114 -4075
COG4 -3232 889
COG5 3937 3634
COG6 1615 -87
COG7 7042 7599
COG8 -5751 -901
COL7A1 -442 8394
COMMD1 6830 6281
COMMD10 8997 5645
COMMD2 6747 6519
COMMD3 3550 2189
COMMD4 -4474 -4677
COMMD5 2041 2403
COMMD6 2908 -705
COMMD7 7063 8101
COMMD8 9672 8565
COMMD9 9687 9081
COPA 6851 10178
COPB1 9548 8670
COPB2 9499 8940
COPE 5686 8054
COPG1 7245 9390
COPG2 8584 9972
COPS2 9383 7627
COPS3 8156 5701
COPS4 6317 5948
COPS5 6344 6899
COPS6 889 3896
COPS7A 3083 7494
COPS7B -6235 -3924
COPS8 3385 -3694
COPZ1 8315 6558
COPZ2 -2992 -9775
CP -10052 1836
CPM 4420 9487
CREBBP -9358 1958
CSF1 3930 -7629
CSNK1D -8768 1189
CST3 5014 -1198
CTBP1 -9138 -4408
CTR9 2483 5441
CTSA 10310 10636
CTSC -3910 5638
CTSZ 9796 10451
CUL1 7475 -10175
CUL2 9537 5772
CUL3 7012 8018
CUL4A 387 433
CUL4B 3280 5583
CUL5 8446 4656
CUL7 -7732 2154
CUL9 -7274 -3995
CYLD 3384 -10382
DAD1 7699 6258
DAG1 -7765 -3574
DAXX -9382 -5524
DCAF10 2271 5999
DCAF11 -5360 -62
DCAF13 327 6103
DCAF16 -8052 -8722
DCAF17 -8338 -7649
DCAF4 -9986 -9203
DCAF5 -10516 -646
DCAF6 7731 9414
DCAF7 -5448 2579
DCAF8 -8846 -5947
DCTN1 -4701 7431
DCTN2 9097 10370
DCTN3 3675 7530
DCTN4 5909 10148
DCTN5 -6881 5731
DCTN6 9751 9405
DCUN1D1 8839 7457
DCUN1D2 1413 -3858
DCUN1D3 -3225 5053
DCUN1D4 1780 -8923
DCUN1D5 1134 6038
DDA1 -3315 5112
DDB1 442 7049
DDB2 -5550 -8542
DDOST 5768 8734
DDX17 -7364 -3383
DDX5 -9939 -6160
DDX58 -8090 -10356
DERL1 -5393 -6496
DERL2 5626 4860
DHDDS -6182 1919
DHPS 1469 694
DNAJC24 -1711 -6784
DNAJC3 9070 9215
DNMT1 -10299 -10563
DNMT3A -6590 -5560
DNMT3B 5329 6370
DOHH -2499 -3583
DOLK -7816 -482
DOLPP1 7664 3611
DPAGT1 6371 3303
DPH1 -7520 -9478
DPH2 -5441 -9209
DPH3 9815 8163
DPH5 3720 3348
DPH6 3336 -4709
DPH7 -7645 -7311
DPM1 5700 4181
DPM2 5599 2835
DPM3 3402 1010
DTL 3159 -1473
DYNC1H1 -9811 -4718
DYNC1I1 378 6338
DYNC1I2 8978 9397
DYNC1LI1 8227 7194
DYNC1LI2 909 7271
DYNLL1 6414 7208
DYNLL2 -5827 -2261
EDEM1 658 3626
EDEM2 9361 9706
EDEM3 9140 9891
EEF1A1 2936 -4796
EEF2 -3419 -1260
EEF2KMT -998 -5887
EID3 -10366 -9628
EIF5A 7900 -1625
EIF5A2 -9744 -9831
ELOB 7369 8033
ELOC 7870 9351
ENAM -5271 3880
ENGASE -7259 -6058
EP300 -2315 7280
EPAS1 191 9357
ERCC8 2267 6718
ESR1 -6841 -8227
ETFB 9144 9286
ETFBKMT 5323 5415
F5 10339 10599
F8 7904 8494
FAM20A 10342 10679
FAM20C 10013 10541
FBN1 2956 6602
FBXL12 -1698 -3377
FBXL13 -1382 3518
FBXL14 -8163 -6300
FBXL15 3436 2720
FBXL16 5507 -10081
FBXL18 -5099 5653
FBXL19 5732 10057
FBXL20 1765 3859
FBXL22 -9153 -6742
FBXL3 1966 670
FBXL4 4486 8310
FBXL5 10325 10075
FBXL8 7525 1281
FBXO10 -9379 306
FBXO11 7621 8299
FBXO15 230 1947
FBXO17 5781 1662
FBXO2 -9215 -4852
FBXO21 -8838 -6075
FBXO22 4944 -234
FBXO27 -8323 -1437
FBXO30 2042 4025
FBXO31 -10125 -10514
FBXO32 -9370 -9624
FBXO4 -4427 -9673
FBXO40 -1666 3411
FBXO41 -7713 3597
FBXO44 -2312 -7442
FBXO6 685 -1568
FBXO7 9204 6315
FBXO9 10306 10429
FBXW11 3233 8725
FBXW12 -8674 -7228
FBXW2 -2414 9274
FBXW4 -8829 -9797
FBXW5 -8630 250
FBXW7 -8232 -6782
FBXW8 -9913 -6070
FBXW9 -8279 -4295
FCGR3B 5213 -2356
FCSK 938 372
FEM1A -6470 -2915
FEM1B 5603 6132
FEM1C 6244 3279
FGF23 1297 -7622
FKBP8 9479 7120
FN1 9912 6648
FN3K 8138 1514
FN3KRP -3429 -8784
FOLR2 8927 -10004
FOXK1 -7937 -4184
FOXK2 -7008 5189
FOXO4 -2621 6949
FPGT 8920 7632
FSTL1 8734 8947
FSTL3 9917 10500
FUCA1 9326 10044
FUCA2 9523 9365
FUOM 2246 -6791
FURIN 7688 10324
FUT8 -9860 -5220
GALNT1 7857 7854
GALNT10 -10083 -731
GALNT11 -128 1173
GALNT12 -6226 -8838
GALNT14 8809 8984
GALNT15 -7591 249
GALNT16 -1377 4947
GALNT2 7832 9935
GALNT3 -5321 762
GALNT4 3872 7513
GALNT5 -3789 945
GALNT6 3621 -2373
GALNT7 8255 10237
GALNT8 2200 -9940
GALNT9 -2006 -10345
GAN -7017 -911
GANAB -7302 2200
GAS6 9599 9997
GATA3 -8401 -10666
GBF1 -8195 348
GCNT1 8047 9868
GCNT3 8783 6468
GCNT4 53 -10714
GCNT7 -5413 4295
GFPT1 -648 -5626
GFPT2 -10443 -7593
GGCX -4196 7376
GLB1 9395 10125
GMDS 6596 6467
GMPPA 5689 5696
GMPPB -2532 -5077
GNE 1982 -5161
GNPNAT1 5088 -9980
GOLGA2 -6652 7914
GOLGB1 -5170 -2548
GOLM1 -7178 -4636
GORASP1 8524 6879
GOSR1 -5651 3364
GOSR2 -1757 3596
GPAA1 3604 7190
GPLD1 -9347 -68
GPS1 -6653 -2413
H2AC11 1918 8407
H2AC20 -3045 2635
H2AC6 4729 7926
H2AW -10307 -8947
H2BC11 3513 8859
H2BC12 7081 10193
H2BC15 -7054 7711
H2BC17 2507 9311
H2BC18 4067 6699
H2BC21 8299 10036
H2BC4 1910 8229
H2BC5 3700 7898
H2BC9 1386 3852
H2BU1 -7775 -6129
HCFC1 -1950 5297
HDAC1 -2168 4381
HDAC2 9181 5219
HDAC4 9252 9753
HDAC7 6776 5329
HERC2 -10819 -7035
HGS 813 5448
HIC1 -10596 -3684
HIF1A 7766 8740
HIF3A -7424 5300
HIPK2 -6191 9863
HLA-A -3294 -7605
HLA-B 5549 -2345
HLTF -6012 -9861
HNRNPC 7228 7789
HNRNPK 8272 8116
HSP90B1 8375 1593
HSPA8 -4222 -8984
ICMT -3482 2649
IDE 9379 9789
IFIH1 -104 -9711
IGFBP3 -6025 -10443
IGFBP4 -9602 -1736
IGFBP7 1257 9806
IKBKE 3422 7754
IKBKG -595 7203
IL33 -2225 -1120
INCENP -9777 -4626
ING2 1932 3993
INO80 -9453 -58
INO80B -8771 1474
INO80C 8300 7445
INO80D -8542 -1707
INO80E -7673 -6983
ITIH2 -4454 -2211
JOSD1 -8978 3969
JOSD2 4078 10170
KAT2A -5724 -9539
KAT2B 629 -1039
KBTBD6 -4372 1950
KBTBD7 2281 6552
KBTBD8 -6734 1825
KCTD6 6285 8491
KCTD7 -9638 -9919
KDELR1 9879 10352
KDELR2 9893 7875
KDELR3 -1354 -6629
KDM1B 5408 4685
KEAP1 1677 6363
KIN 4085 7905
KLHL11 -8639 -5691
KLHL2 10041 9861
KLHL20 -8559 -7700
KLHL21 -3809 -685
KLHL22 -9362 -10073
KLHL25 -8531 -9408
KLHL3 -8412 -10585
KLHL42 -7950 -3516
KLHL5 9233 3225
KLHL9 4068 3435
KTN1 6115 7195
L3MBTL2 -8122 -6280
LAMB1 -362 9598
LAMB2 -7353 -2442
LAMC1 7484 10634
LARGE1 -8590 -9364
LARGE2 71 -6535
LEO1 4619 4039
LGALS1 9190 10543
LMAN1 -2101 -9736
LMAN2 6893 7688
LMAN2L 7489 7830
LMO7 -4870 -8046
LRR1 -1979 -4550
LRRC41 4228 8465
LSAMP -1894 -2051
LTBP1 6416 8528
LY6E -10567 -10660
LYPD2 -10944 -8933
LYPD3 -2827 -4512
LYPD5 2958 -4368
MAGT1 4037 5258
MAN1A1 6497 9657
MAN1A2 -6602 1179
MAN1B1 -3746 -4312
MAN1C1 1396 -8830
MAN2A1 1336 -1270
MAN2A2 -4209 7794
MANEA 7385 -2869
MAP3K7 2469 7237
MARCHF6 -6986 224
MAT2B 1423 -7517
MAVS 5118 9914
MBD1 -584 3510
MBD5 -5473 7027
MBD6 7636 9087
MBTPS1 -1835 5184
MCFD2 7974 9249
MCRS1 -3848 -4148
MDC1 -9511 -9378
MDGA1 3355 5855
MDM2 3788 6943
MDM4 1937 -1455
MELTF -2514 8496
MEN1 -8958 -4079
METTL21A 6161 7752
METTL22 -6204 7602
MFGE8 -471 7078
MGAT1 362 7982
MGAT2 -3625 2214
MGAT3 174 -9979
MGAT4A -482 -6981
MGAT4B 9034 9077
MGAT4C 1409 -1128
MGAT5 -8963 1454
MIA2 6400 5836
MIA3 40 -2504
MITF 9251 9793
MLEC -220 4725
MOGS -5070 -3156
MPDU1 8992 9338
MPI -2165 -8742
MRTFA 7162 9194
MSLN -2860 7051
MTA1 1434 -1530
MUC1 9675 8255
MUC12 -9171 -8879
MUC16 -3838 -3439
MUC20 3464 -5169
MUC4 244 775
MUC5B -6905 -2911
MUC6 -1039 -983
MUCL1 -1284 2959
MUL1 -1585 1181
MVD -7748 -625
MXRA8 -1852 -7282
MYC 8955 225
MYSM1 -6061 -3433
NAE1 -4396 -8503
NAGK 7844 -141
NANP -8888 -3104
NANS 9209 8150
NAPA 4940 2147
NAPB -4472 1066
NAPG 5219 7040
NCOA1 -3324 5089
NCOA2 -7260 1011
NCOR2 -2998 10117
NDC1 -8939 -10351
NEDD8 5330 8439
NEGR1 1318 2002
NEU1 9609 10026
NEU3 -5831 -3117
NEURL2 -6007 -3899
NFKB2 5450 -6553
NFKBIA 8114 5809
NFRKB -6391 -1489
NGLY1 2029 1344
NICN1 -7968 -3234
NLRP3 9713 9646
NOD1 -10556 -9537
NOD2 9289 9320
NOP58 4347 -8474
NPL 10251 10671
NPM1 4725 -8730
NR1H2 4953 7742
NR1H3 -3942 -2012
NR2C1 -6557 -6054
NR3C1 -4556 1036
NR3C2 -4046 -10210
NR4A2 -6619 -4440
NRIP1 2987 7453
NRN1 9016 9717
NRN1L -3714 -7203
NSF 8767 10358
NSMCE1 8586 7122
NSMCE2 7669 7670
NSMCE3 -9213 -8375
NSMCE4A -7269 -7408
NTNG2 908 3234
NUB1 -4704 -10192
NUCB1 9568 10046
NUDT14 4308 -5033
NUP107 -8816 -8274
NUP133 -5348 776
NUP153 -6945 -3734
NUP155 -5317 -7756
NUP160 -2219 -8347
NUP188 -9248 -9221
NUP205 -7213 -7389
NUP210 -10535 -6252
NUP214 8257 8111
NUP35 -4124 -8851
NUP37 5728 6078
NUP42 2461 -1423
NUP43 -3773 -8208
NUP50 6620 2938
NUP54 6985 -5266
NUP58 9614 9817
NUP62 6407 -2545
NUP85 2286 -2781
NUP88 -8115 -8802
NUP93 -5242 -7982
NUP98 -1200 2149
NUS1 9633 9296
OBSL1 -7602 -345
OGT -6432 -5075
OS9 9572 10053
OTUB1 970 1988
OTUB2 -1503 154
OTUD3 -6876 -7502
OTUD5 -6013 -4938
OTUD7A -8529 -10042
OTUD7B -10613 -10397
OTULIN -4985 93
P4HB 8507 9962
PAF1 -2354 3819
PARK7 7441 7247
PARP1 -10265 -8043
PCGF2 -7146 -2017
PCNA 5892 -5806
PDIA3 7841 5995
PDIA6 8613 5542
PEX10 -6484 -1459
PEX12 -4272 -7256
PEX13 451 2438
PEX14 -3052 5973
PEX2 4206 4939
PEX5 -792 5644
PGAP1 7514 -8990
PGM3 3949 1433
PHC1 -5740 -6201
PHC2 8347 10344
PHC3 -5903 -5109
PIAS1 9454 7475
PIAS2 -6143 -185
PIAS3 -4112 2697
PIAS4 -2221 7565
PIGA -4605 -6930
PIGB 6879 5928
PIGC 4772 -1222
PIGF 9130 9388
PIGG -4669 -7892
PIGH -7652 -4318
PIGK -2527 -2874
PIGL -8740 -9585
PIGM 4625 553
PIGN -754 5724
PIGO -8250 -1808
PIGP 2854 -2253
PIGQ 446 2181
PIGS 5135 8318
PIGT 384 2968
PIGU 7469 -7985
PIGV -6931 -1662
PIGW -8077 -8798
PIGX 9526 3104
PIGZ -5329 4798
PLAUR 9724 9965
PML -917 -9991
PMM1 -289 4354
PMM2 8358 -635
PNPLA2 9549 9963
POFUT2 -8032 -8757
POLB 8076 -6859
POM121 -9318 -4714
POM121C -10088 -6969
POMGNT1 -8871 -8356
POMGNT2 -9331 -518
POMK -8927 -1035
POMT1 -2490 -6701
POMT2 -2061 5039
PPARA -7992 2961
PPARG 10358 10670
PPARGC1A 5105 6389
PPP6C 9263 7953
PPP6R1 -4291 7176
PPP6R3 1461 4805
PREB 4312 7535
PRKCSH 1054 6027
PRKDC -9391 -8118
PRMT3 7748 6013
PROC -10123 -964
PROS1 8002 7705
PROZ 1303 -2090
PRSS21 2521 -331
PRSS23 -10980 -10270
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
PTEN 8668 9329
PTP4A2 -29 5540
PTRH2 9576 1725
PUM2 2229 -1194
QSOX1 9888 10475
RAB10 9916 9959
RAB11A 9367 8536
RAB11B 1061 4700
RAB12 7246 1150
RAB13 10172 10518
RAB14 8765 8436
RAB15 -6192 -6841
RAB18 9744 7495
RAB19 -4135 2014
RAB1A 10223 9909
RAB1B 8291 9474
RAB20 9891 9574
RAB21 7164 6786
RAB22A -1971 -822
RAB23 1878 -958
RAB24 5628 2552
RAB26 6390 -8097
RAB27A 9159 9152
RAB27B -6595 4754
RAB29 -9948 -6941
RAB2A 9390 9368
RAB2B -5433 -5132
RAB30 -9823 -7791
RAB31 10008 10290
RAB32 10118 10403
RAB33A -10259 -9079
RAB33B 8566 5483
RAB34 8282 10051
RAB35 -5746 3696
RAB36 3694 2526
RAB37 -10867 -10259
RAB38 -7625 -1532
RAB39A 9485 8386
RAB39B -8852 -10419
RAB3A 6440 9746
RAB3B -3535 -836
RAB3D 9091 10183
RAB40B -5615 -9765
RAB40C 6340 9679
RAB41 -3046 -2678
RAB42 -2241 6783
RAB43 3769 5508
RAB44 6119 -1305
RAB4A 8673 6735
RAB4B -3971 4641
RAB5A 9230 7808
RAB5B -279 7773
RAB5C 8923 9415
RAB6A 8383 9332
RAB6B 3094 7305
RAB7A 9941 9609
RAB7B -9067 5680
RAB8A 1690 6186
RAB8B 6481 8127
RAB9A 5902 5709
RAB9B -6342 1453
RABGGTA -136 -927
RABGGTB 6484 -3588
RAD18 -9841 -9036
RAD21 2777 1005
RAD23A 8229 6050
RAD23B 9300 9828
RAD52 511 3694
RAE1 7170 7531
RANBP2 457 512
RANGAP1 -9450 -10158
RARA -2636 7214
RBBP5 1478 542
RBBP7 -9908 -7503
RBX1 1119 4750
RCE1 -3223 -1780
RCN1 -231 -9185
RECK 1459 -7513
RELA -2847 -1359
RENBP 6010 7004
RFT1 6431 989
RHOA 9541 9090
RHOT1 10236 10427
RING1 -1586 -738
RIPK1 -8110 -7415
RIPK2 8675 2009
RNF103 -9664 -3083
RNF123 3263 7618
RNF135 9310 10213
RNF139 541 907
RNF144A -7535 -10560
RNF146 6563 10456
RNF152 -2484 3199
RNF168 -9623 -2160
RNF181 6543 7149
RNF185 6388 8065
RNF2 5504 4715
RNF20 4328 8011
RNF40 -1071 8028
RNF5 -7305 -918
RNF7 8170 9018
RORA -10427 -10611
RPA1 -9749 -9650
RPN1 8456 8842
RPN2 7659 7805
RPS2 1634 -3308
RPS27A -1868 -5386
RRAGA 3684 7518
RTF1 -528 3051
RTN4RL1 4830 1119
RTN4RL2 4829 8795
RUVBL1 1938 -4991
RWDD3 6703 805
RXRA 6389 8760
SAE1 -7363 -1416
SAFB -609 1726
SAR1B 9412 8914
SATB1 -3273 -7984
SATB2 7299 8802
SBSPON -4934 -2575
SCFD1 6826 7619
SCMH1 3592 -4122
SDC2 6034 5778
SEC13 6324 5321
SEC16A -6613 6860
SEC16B -340 3720
SEC22A 5519 1741
SEC22B 9017 4952
SEC22C 2177 1557
SEC23A 8250 8136
SEC23IP 6616 2151
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SEC31A 1943 6528
SEH1L 8372 -4799
SEL1L 6263 8390
SELENOS -1552 -465
SEM1 5210 6938
SEMA5A -4342 -5873
SEMA5B -3073 5550
SENP1 -5678 -3671
SENP2 6296 5674
SENP5 -2470 -2811
SENP8 9067 3120
SERPINA1 10186 10295
SERPINA10 4001 6657
SERPIND1 -1857 -807
SHISA5 -2440 -4865
SHPRH -7703 -3441
SIAH2 9387 7192
SIN3A -8565 -8326
SKP1 8911 4204
SKP2 -4203 -2704
SLC17A5 5214 7726
SLC35A1 9584 8867
SLC35C1 -420 442
SMAD1 4734 10482
SMAD2 1682 7725
SMAD3 -10166 -9199
SMAD4 -3390 -7669
SMAD7 -10989 -9842
SMC1A -2067 3659
SMC3 6125 -761
SMC5 21 -3337
SMC6 -2798 1967
SMURF2 -9485 -7896
SNX3 10083 10139
SOCS2 2960 -4731
SOCS3 10312 10656
SOCS5 2203 5831
SOCS6 8062 10245
SP100 2431 6566
SP3 4632 4221
SPON1 -5995 -7498
SPON2 -10960 -9851
SPRN -6438 -8244
SPSB1 -2027 858
SPSB2 -5424 -1034
SPSB3 -7459 -7612
SPTA1 9220 7274
SPTAN1 -10045 -9563
SPTB 9406 9121
SPTBN1 -8781 -6351
SPTBN2 -6201 -2780
SPTBN5 -7032 -3485
SRD5A3 7881 1403
ST3GAL1 -7981 -6569
ST3GAL2 7602 9502
ST3GAL3 -1028 2393
ST3GAL4 -9447 4972
ST3GAL5 -6579 -9119
ST3GAL6 9322 5613
ST6GAL1 -10455 -8619
ST6GAL2 -1637 4319
ST6GALNAC1 4074 -8373
ST6GALNAC2 6173 3933
ST6GALNAC3 7932 10316
ST6GALNAC4 -8293 105
ST6GALNAC6 -10568 -10104
ST8SIA1 -1213 -9032
ST8SIA4 8757 9211
ST8SIA5 -1730 5154
ST8SIA6 -10591 -7843
STAG1 -5124 -2431
STAG2 6585 5209
STAM 2880 1495
STAM2 8313 7133
STAMBP 3327 5478
STAMBPL1 1806 -8090
STS 176 5094
STT3A 6910 6477
STX17 -2656 -9125
STX5 6777 7536
SUDS3 3710 6309
SUMF1 9836 10078
SUMF2 -10639 -7655
SUMO1 9138 8090
SUMO2 8206 6024
SUMO3 9080 7937
SUZ12 4242 493
SYVN1 25 3387
TAB1 7080 3716
TADA2B 115 6392
TADA3 1436 8757
TAF10 4355 8862
TAF9B 7166 -3686
TBC1D20 -5268 1442
TDG 7704 8376
TECTA -7980 -1497
TF 2007 3922
TFG 9720 8105
TFPT 4130 7121
TGFA 5895 9650
TGFB1 984 3574
TGFBR1 -7710 -1431
TGFBR2 -6958 4321
TGOLN2 6907 10123
THBS1 1255 9820
THRA -7716 -2644
THRB -6667 1039
THSD1 5465 -5825
THSD4 -5193 -420
THSD7A -8644 -8243
TIMP1 6709 10267
TMED10 4984 4383
TMED2 6691 7410
TMED3 3770 4652
TMED7 9644 9106
TMED9 7191 9462
TMEM115 3217 3929
TMEM129 3386 2625
TMEM132A 6517 5305
TNC -1884 -4659
TNFAIP3 -10143 -6698
TNIP1 8492 9165
TNIP2 -929 4907
TNIP3 -9267 -3770
TNKS -8859 -2898
TNKS2 642 4031
TOMM20 6419 -3688
TOMM70 -304 -4929
TOP1 9439 8587
TOP2A 3862 1492
TOP2B 456 1377
TOPORS 2495 932
TP53 -5246 -8954
TP53BP1 -8994 -6962
TPGS1 532 3544
TPGS2 2666 -1763
TPR -4478 -7012
TPST1 2152 10253
TPST2 -8642 6809
TRAF2 -7822 -10338
TRAF3 3014 -4910
TRAF6 -4471 1582
TRAPPC1 6932 9117
TRAPPC10 -10367 -4001
TRAPPC2 -9388 -4103
TRAPPC2L 4084 340
TRAPPC3 8513 8500
TRAPPC4 -6015 -5250
TRAPPC5 -685 471
TRAPPC6A -1341 -9288
TRAPPC6B 6911 6051
TRAPPC9 3787 8190
TRIM13 1180 1925
TRIM25 9125 8899
TRIM27 9100 8140
TRIM28 -6726 -6061
TRRAP -9540 -2608
TSTA3 6850 5442
TTL -8475 -305
TTLL1 6976 -4981
TTLL11 -5931 -3572
TTLL12 3828 4424
TTLL13P -9620 -959
TTLL3 -3131 138
TTLL4 8786 7882
TTLL5 -6678 3401
TTLL7 4818 6480
TUBA1A 8387 6160
TUBA1B 5908 5651
TUBA1C 8111 6802
TUBA3D -3044 -8193
TUBB1 -2192 5599
TUBB2A 8824 9899
TUBB3 -2780 -397
TUBB4A -3617 -9555
TUBB4B 7592 5692
TUBB6 -4633 8489
TULP4 -10353 -1559
UAP1 -9713 -9507
UBA1 5026 7870
UBA2 5359 -1042
UBA3 10160 9196
UBA52 2067 260
UBA6 5769 6471
UBB 7788 3835
UBC 2562 2822
UBE2A 8378 8872
UBE2B 8863 6372
UBE2C 5494 3509
UBE2D1 10262 10093
UBE2D2 5413 5174
UBE2D3 9631 8934
UBE2E1 9885 8679
UBE2E3 5701 7288
UBE2F 3599 8133
UBE2G1 3382 7080
UBE2G2 945 -5649
UBE2H 4979 8492
UBE2I -1027 5239
UBE2J2 7863 9279
UBE2K 9809 8979
UBE2L3 9173 8427
UBE2M 3363 8550
UBE2N 7813 4195
UBE2Q2 -7040 -9475
UBE2R2 8147 9175
UBE2S 6887 3531
UBE2T -367 -5197
UBE2V2 8803 5733
UBE2W 9550 8060
UBE2Z -8053 -7521
UBXN1 -4500 2432
UBXN7 -4238 5404
UCHL3 9318 3246
UCHL5 3830 -4523
UGGT1 364 6869
UGGT2 9481 7067
UHRF2 -8362 -6704
UIMC1 9560 10225
USO1 8607 7741
USP10 9221 5348
USP11 -10967 -9911
USP12 6071 6628
USP13 -7140 -215
USP14 17 1934
USP15 7488 4692
USP16 5307 -4461
USP18 -10752 -10494
USP19 -8647 -341
USP20 -7443 -10527
USP21 -1984 -3521
USP22 381 8949
USP24 -10420 -7102
USP25 6368 -2554
USP28 -11000 -9568
USP3 8702 10300
USP30 2947 6122
USP33 5176 5090
USP34 -6599 1766
USP37 -8425 -5863
USP4 7575 8759
USP42 -9583 -8883
USP44 -6616 -4613
USP47 -5975 3456
USP48 7646 7022
USP49 4500 7097
USP5 -2500 1235
USP7 -171 8779
USP8 8356 8962
USP9X 1306 5792
VCAN 10280 10667
VCP 7591 6702
VCPIP1 -2942 -855
VCPKMT -2252 -449
VDAC1 7258 5858
VDAC2 9090 9227
VDAC3 3161 3488
VDR 5697 10052
VHL -700 5272
VNN1 10163 10414
VNN2 9682 9921
VNN3 4358 5661
WAC -1830 6636
WDR20 -2136 1868
WDR48 -6698 -8483
WDR5 -1340 1040
WDR61 5735 -802
WDTC1 -6200 7229
WFS1 -9996 -7328
WRN -7839 -10190
WSB1 9732 9122
WSB2 9591 8588
XPC -10096 -8826
XPNPEP2 -10576 -9739
XRCC4 8532 8109
YKT6 1766 6226
YOD1 6941 7492
YY1 -5236 -1577
ZBED1 -2882 -3813
ZBTB16 -10578 8072
ZNF131 -4771 -8881
ZNF350 -2178 -448
ZRANB1 3511 -64



Signaling by Interleukins

Signaling by Interleukins
metric value
setSize 385
pMANOVA 3.3e-21
p.adjustMANOVA 3e-19
s.dist 0.361
s.low.CRP 0.274
s.high.CRP 0.235
p.low.CRP 2.66e-20
p.high.CRP 2.17e-15




Top 20 genes
Gene low CRP high CRP
CSF2RA 10368 10661
S100A12 10367 10617
SOCS3 10312 10656
VAMP7 10303 10569
CD36 10363 10493
SERPINB2 10291 10534
CCR2 10299 10514
FPR1 10352 10383
TALDO1 10319 10395
VIM 10149 10565
DUSP3 10238 10410
PTAFR 10084 10562
ITGAM 10114 10483
PRKACA 9995 10558
LMNB1 10350 10018
GRB2 9960 10389
TNFRSF1A 10046 10283
IL10RB 10086 10181
CA1 10237 10011
GSTO1 9989 10215

Click HERE to show all gene set members

All member genes
low CRP high CRP
AGER 1815.0 2573.0
AIP -7421.0 -3297.0
AKT1 -5096.0 2421.0
ALOX15 -5374.0 -9427.0
ALOX5 9735.0 9772.0
ANXA1 8538.0 8818.0
ANXA2 9791.0 10138.0
APP 10085.0 9961.0
ARF1 9085.0 10196.0
ATF1 9088.0 8764.0
ATF2 8316.0 2303.0
BATF 7739.0 7840.0
BCL2 5399.0 -4548.0
BCL2L1 9471.0 8431.0
BCL6 10173.0 10019.0
BIRC5 5078.0 5144.0
BLNK -7737.0 -4051.0
BOLA2 3751.0 -209.0
BRWD1 -7651.0 -7506.0
BTRC -7062.0 1812.0
CA1 10237.0 10011.0
CANX 7507.0 7257.0
CAPZA1 9332.0 9316.0
CASP1 9611.0 2857.0
CASP3 4165.0 2978.0
CBL 1852.0 8579.0
CCL2 -10551.0 -10635.0
CCL3 -1192.0 -5558.0
CCL4 -10973.0 -8565.0
CCL5 -10431.0 -10290.0
CCND1 -3107.0 -2342.0
CCR1 10287.0 9826.0
CCR2 10299.0 10514.0
CCR5 -9310.0 -7370.0
CD36 10363.0 10493.0
CD4 1506.0 -6863.0
CD80 -7610.0 -7443.0
CD86 6726.0 -1548.0
CDC42 9246.0 8570.0
CDKN1A -1680.0 4429.0
CEBPD 8189.0 10136.0
CFL1 9368.0 9341.0
CHUK 9608.0 9191.0
CISH 9949.0 -655.0
CLCF1 -9992.0 -10173.0
CNN2 4530.0 6242.0
CNTF 4718.0 7198.0
COL1A2 4726.0 5641.0
CREB1 2938.0 -595.0
CRK 9214.0 9663.0
CRKL -1879.0 4224.0
CRLF1 2635.0 -6307.0
CSF1 3930.0 -7629.0
CSF1R -7879.0 1273.0
CSF2RA 10368.0 10661.0
CSF2RB 9224.0 5475.0
CSF3R 9933.0 8675.0
CTF1 -3336.0 6154.0
CTSG 9668.0 2004.0
CUL1 7475.0 -10175.0
CXCL1 7627.0 4227.0
CXCL10 7706.0 -10646.0
CXCL2 2912.0 3723.0
CXCL8 5888.0 -3003.0
DUSP3 10238.0 10410.0
DUSP4 -3900.0 -8336.0
DUSP6 7156.0 -2241.0
DUSP7 -5905.0 -3113.0
EBI3 -8326.0 8419.0
ELK1 5371.0 2922.0
F13A1 9500.0 8453.0
FASLG -10999.0 -10620.0
FBXW11 3233.0 8725.0
FCER2 -3881.0 -3466.0
FGF2 8825.0 5391.0
FN1 9912.0 6648.0
FOS 7518.0 2641.0
FOXO1 -8890.0 -9341.0
FOXO3 2533.0 10065.0
FPR1 10352.0 10383.0
FSCN1 8944.0 8203.0
FYN -10683.0 -7016.0
GAB2 6405.0 10289.0
GATA3 -8401.0 -10666.0
GRB2 9960.0 10389.0
GSTO1 9989.0 10215.0
H3C15 182.5 4598.5
HAVCR2 -3410.0 9527.0
HCK 10073.0 9850.0
HGF 8952.0 9949.0
HIF1A 7766.0 8740.0
HMGB1 3409.0 1050.0
HMOX1 6215.0 10321.0
HNRNPA2B1 4667.0 7450.0
HNRNPDL -6946.0 -8564.0
HNRNPF 5903.0 5564.0
HSP90AA1 5650.0 1245.0
HSP90B1 8375.0 1593.0
HSPA8 -4222.0 -8984.0
HSPA9 -1007.0 -4614.0
ICAM1 10112.0 3884.0
IFNG -4670.0 -9064.0
IFNLR1 -9277.0 -6455.0
IGHE -4940.0 -4979.0
IGHG1 -3727.0 -9610.0
IGHG4 -6480.0 -3573.0
IKBKB -6356.0 -1160.0
IKBKG -595.0 7203.0
IL10 9226.0 10431.0
IL10RA -10506.0 -7351.0
IL10RB 10086.0 10181.0
IL11RA 3928.0 -9255.0
IL12A 3147.0 -8099.0
IL12RB1 -10018.0 -10649.0
IL12RB2 -10678.0 -9666.0
IL13RA1 6354.0 3540.0
IL15 4243.0 -5326.0
IL15RA 7738.0 301.0
IL16 -9878.0 -8592.0
IL17C -4476.0 2603.0
IL17RA 9934.0 10045.0
IL17RB -3966.0 -706.0
IL17RC 5212.0 -2958.0
IL17RE -3066.0 -335.0
IL18 7946.0 10001.0
IL18BP -6907.0 -7996.0
IL18R1 -10208.0 2501.0
IL18RAP -10986.0 1316.0
IL19 5400.0 8293.0
IL1B 9843.0 323.0
IL1R1 8837.0 9561.0
IL1R2 7717.0 2515.0
IL1RAP -137.0 7646.0
IL1RL1 4851.0 -7621.0
IL1RN 10354.0 9802.0
IL20RB -3801.0 -8203.0
IL21R -10580.0 -10516.0
IL23A 2448.0 -10033.0
IL24 -9597.0 -7293.0
IL27 7689.0 8106.0
IL27RA -5135.0 5710.0
IL2RA 2298.0 -5478.0
IL2RB -10992.0 -10437.0
IL2RG -9921.0 -10217.0
IL31RA -708.0 -7497.0
IL32 -3097.0 -10337.0
IL33 -2225.0 -1120.0
IL3RA -7725.0 -10665.0
IL4 -8327.0 -10394.0
IL4R 2336.0 7941.0
IL5RA -9017.0 -10618.0
IL6R 9817.0 7220.0
IL6ST 8195.0 4822.0
IL7 -8228.0 -5430.0
IL7R -2724.0 -10582.0
IL9R -10074.0 -10257.0
INPP5D -10748.0 -563.0
INPPL1 9545.0 10037.0
IRAK1 2858.0 6473.0
IRAK2 -10838.0 -5931.0
IRAK3 9582.0 10412.0
IRF4 -4897.0 -8396.0
IRS1 1115.0 1691.0
IRS2 3826.0 10432.0
ITGAM 10114.0 10483.0
ITGAX 4703.0 8540.0
ITGB1 -332.0 1996.0
ITGB2 9132.0 10614.0
JAK1 -10460.0 -6095.0
JAK2 8894.0 -2339.0
JAK3 9823.0 8824.0
JUN 481.0 -1015.0
JUNB 7420.0 5447.0
LAMA5 832.0 -94.0
LCK -9185.0 -10569.0
LCN2 9492.0 6870.0
LCP1 9694.0 9469.0
LGALS9 7016.0 4726.0
LMNB1 10350.0 10018.0
LYN 8483.0 8583.0
MAOA 9730.0 10208.0
MAP2K1 8861.0 10365.0
MAP2K3 8777.0 8502.0
MAP2K4 5525.0 7430.0
MAP2K6 8704.0 10103.0
MAP2K7 -1568.0 2972.0
MAP3K3 6459.0 9695.0
MAP3K7 2469.0 7237.0
MAP3K8 -7148.0 10028.0
MAPK1 -1086.0 9427.0
MAPK10 6946.0 6199.0
MAPK11 8895.0 6888.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MAPK7 -9798.0 3379.0
MAPK8 -794.0 -7374.0
MAPK9 -6911.0 1519.0
MAPKAPK2 -10648.0 4888.0
MAPKAPK3 7908.0 10021.0
MCL1 8331.0 6386.0
MEF2A 8559.0 9073.0
MEF2C 5395.0 -197.0
MIF -427.0 -5003.0
MMP1 8623.0 7665.0
MMP9 8967.0 1371.0
MSN -4563.0 7812.0
MTAP 3682.0 642.0
MUC1 9675.0 8255.0
MYC 8955.0 225.0
MYD88 8926.0 8524.0
NANOG -579.0 488.0
NDN 1825.0 5967.0
NFKB1 8527.0 5403.0
NFKB2 5450.0 -6553.0
NFKBIA 8114.0 5809.0
NFKBIB -5904.0 1139.0
NKIRAS1 1465.0 2281.0
NKIRAS2 9577.0 10434.0
NOD1 -10556.0 -9537.0
NOD2 9289.0 9320.0
OPRD1 -7245.0 144.0
OPRM1 6190.0 4645.0
OSM 8836.0 6586.0
OSMR -7699.0 -1587.0
P4HB 8507.0 9962.0
PAK2 9098.0 8874.0
PDCD4 -7565.0 -9703.0
PELI1 8918.0 5667.0
PELI2 7349.0 9515.0
PELI3 -320.0 9317.0
PIK3CA 5168.0 6821.0
PIK3CB 9880.0 9707.0
PIK3CD -932.0 3422.0
PIK3R1 -7314.0 -9108.0
PIK3R2 2369.0 6022.0
PIK3R3 -10971.0 -7175.0
PIM1 10092.0 7166.0
PITPNA 8374.0 6227.0
POMC 2426.0 -2728.0
POU2F1 -4769.0 4835.0
PPIA 285.0 1417.0
PPP2CA 9766.0 8577.0
PPP2CB 9136.0 9093.0
PPP2R1A 1997.0 5379.0
PPP2R1B 3691.0 1706.0
PPP2R5D -5620.0 3209.0
PRKACA 9995.0 10558.0
PRTN3 10009.0 6834.0
PSMA1 9165.0 8953.0
PSMA2 9175.0 6486.0
PSMA3 8811.0 -3545.0
PSMA4 8595.0 258.0
PSMA5 6009.0 -5256.0
PSMA6 9365.0 6915.0
PSMA7 6006.0 7700.0
PSMB1 8548.0 3242.0
PSMB10 -972.0 -8733.0
PSMB2 8065.0 5797.0
PSMB3 8817.0 8326.0
PSMB4 4018.0 3039.0
PSMB5 8225.0 9508.0
PSMB6 6959.0 8991.0
PSMB7 9346.0 8950.0
PSMB8 5148.0 -5793.0
PSMB9 -5133.0 -10716.0
PSMC1 7220.0 8544.0
PSMC2 4967.0 6378.0
PSMC3 2824.0 4673.0
PSMC4 -9365.0 -3210.0
PSMC5 2913.0 2050.0
PSMC6 9832.0 7978.0
PSMD1 8509.0 8974.0
PSMD10 6347.0 2957.0
PSMD11 8697.0 9183.0
PSMD12 9648.0 8351.0
PSMD13 7185.0 6511.0
PSMD14 7985.0 5632.0
PSMD2 7347.0 8049.0
PSMD3 3057.0 6067.0
PSMD4 8627.0 9334.0
PSMD5 1520.0 8328.0
PSMD6 9864.0 9375.0
PSMD7 9212.0 6772.0
PSMD8 6905.0 6585.0
PSMD9 7407.0 8869.0
PSME1 -1137.0 -9489.0
PSME2 3614.0 -10267.0
PSME3 9544.0 8452.0
PSME4 -8419.0 -464.0
PSMF1 7685.0 5740.0
PTAFR 10084.0 10562.0
PTGS2 8500.0 5863.0
PTK2B 2160.0 9588.0
PTPN11 3471.0 9688.0
PTPN12 6377.0 9874.0
PTPN13 -7614.0 -7223.0
PTPN14 -908.0 -488.0
PTPN18 -3234.0 9001.0
PTPN2 8577.0 10537.0
PTPN20 312.0 2477.0
PTPN23 -6746.0 561.0
PTPN4 -10744.0 -10485.0
PTPN6 3230.0 7923.0
PTPN7 -8688.0 -7879.0
PTPN9 -3258.0 9595.0
RAG1 -10667.0 -8657.0
RALA 8746.0 2764.0
RAP1B -3254.0 7324.0
RAPGEF1 -10785.0 -4187.0
RBX1 1119.0 4750.0
RELA -2847.0 -1359.0
RHOU 9641.0 10458.0
RIPK2 8675.0 2009.0
RORA -10427.0 -10611.0
RORC 428.0 -9827.0
RPLP0 6333.0 -1009.0
RPS27A -1868.0 -5386.0
RPS6KA1 1245.0 8996.0
RPS6KA2 -5842.0 2331.0
RPS6KA3 1034.0 3942.0
RPS6KA5 70.0 -10393.0
S100A12 10367.0 10617.0
S100B -10129.0 814.0
S1PR1 -10247.0 -7325.0
SEM1 5210.0 6938.0
SERPINB2 10291.0 10534.0
SHC1 3101.0 5292.0
SIGIRR -8187.0 -8512.0
SKP1 8911.0 4204.0
SMAD3 -10166.0 -9199.0
SMARCA4 -4137.0 8319.0
SNRPA1 -3497.0 -6914.0
SOCS1 8467.0 6659.0
SOCS2 2960.0 -4731.0
SOCS3 10312.0 10656.0
SOCS5 2203.0 5831.0
SOD1 3597.0 -3501.0
SOD2 9488.0 2250.0
SOS1 2394.0 -4661.0
SOS2 8073.0 8815.0
SQSTM1 5451.0 -188.0
STAT1 -3982.0 -10718.0
STAT2 -2902.0 -9912.0
STAT3 9401.0 8593.0
STAT4 -10652.0 -10680.0
STAT5A 8323.0 7832.0
STAT5B 4680.0 4956.0
STAT6 195.0 7872.0
STX1A -8692.0 -2626.0
STX3 9788.0 8019.0
STX4 -4764.0 2706.0
STXBP2 9851.0 10088.0
SYK 9750.0 10350.0
TAB1 7080.0 3716.0
TAB2 8556.0 6836.0
TAB3 215.0 4794.0
TALDO1 10319.0 10395.0
TBK1 8071.0 5122.0
TCP1 9179.0 4168.0
TEC 6790.0 9842.0
TGFB1 984.0 3574.0
TIMP1 6709.0 10267.0
TNF 855.0 -8625.0
TNFRSF1A 10046.0 10283.0
TNFRSF1B -1892.0 8266.0
TNIP2 -929.0 4907.0
TOLLIP 8936.0 8482.0
TP53 -5246.0 -8954.0
TRAF6 -4471.0 1582.0
TXLNA -1087.0 -243.0
TYK2 4043.0 8696.0
UBA52 2067.0 260.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2N 7813.0 4195.0
UBE2V1 8249.0 8108.0
VAMP2 -4429.0 -10264.0
VAMP7 10303.0 10569.0
VAV1 6299.0 7892.0
VEGFA 7943.0 7054.0
VIM 10149.0 10565.0
VRK3 -2450.0 3426.0
YES1 -10892.0 -9337.0
YWHAZ 7112.0 6341.0
ZEB1 -2479.0 -8659.0



CD22 mediated BCR regulation

CD22 mediated BCR regulation
metric value
setSize 58
pMANOVA 2.23e-20
p.adjustMANOVA 1.9e-18
s.dist 0.539
s.low.CRP 0.069
s.high.CRP -0.534
p.low.CRP 0.363
p.high.CRP 1.87e-12




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580
IGLV3-19 2884 -7478
IGHV1-2 7949 -2404

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD22 -4690 -6104
CD79A -6293 -3766
CD79B -8417 -6298
IGHD -3784 -6091
IGHM -323 -1745
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV6-57 4672 -7639
IGLV7-43 165 2135
LYN 8483 8583
PTPN6 3230 7923



Translation

Translation
metric value
setSize 294
pMANOVA 4.72e-20
p.adjustMANOVA 3.78e-18
s.dist 0.242
s.low.CRP 0.241
s.high.CRP -0.0243
p.low.CRP 1.16e-12
p.high.CRP 0.474




Top 20 genes
Gene low CRP high CRP
MRPL50 7536 -7017
MRPL42 8661 -5375
WARS2 6233 -6540
AIMP1 7312 -5118
LARS1 7998 -4102
SEC11C 4927 -6276
WARS1 3334 -8797
MRPL14 4494 -5447
PPA1 9593 -2306
TRAM1 5957 -3682
RPS3A 5865 -3619
EEF1A1P5 5880 -3321
GFM1 4888 -3769
KARS1 8005 -2267
RPS26 3527 -5041
MRPL1 5472 -2755
RPL18 3381 -4456
FARS2 2802 -5254
EEF1A1 2936 -4796
EIF5B 5000 -2620

Click HERE to show all gene set members

All member genes
low CRP high CRP
AARS1 -407 -5945
AARS2 -9558 -8848
AIMP1 7312 -5118
AIMP2 6547 729
APEH -6699 1881
AURKAIP1 4008 3839
CARS1 6786 8749
CARS2 8428 7398
CHCHD1 7055 8561
DAP3 6688 2267
DARS1 9222 1575
DARS2 -5219 6131
DDOST 5768 8734
EARS2 -9598 -9423
EEF1A1 2936 -4796
EEF1A1P5 5880 -3321
EEF1A2 -784 -5416
EEF1B2 1452 -2929
EEF1D 1598 -3621
EEF1E1 3565 3869
EEF1G 2362 -121
EEF2 -3419 -1260
EIF1AX 8840 678
EIF2B1 6642 3778
EIF2B2 -5594 5830
EIF2B3 1542 -3961
EIF2B4 -916 6165
EIF2B5 -3383 -5583
EIF2S1 9228 5747
EIF2S2 9166 7187
EIF2S3 7994 6909
EIF3A 2392 2708
EIF3B 1444 -5363
EIF3C -2681 3297
EIF3D 6457 -101
EIF3E 8520 1078
EIF3F 1895 3147
EIF3G 1785 746
EIF3H 8550 5125
EIF3I 8018 5002
EIF3J 8650 3134
EIF3K 4950 1772
EIF3L 6453 2490
EIF3M 9649 3612
EIF4A1 9825 8652
EIF4A2 -4531 -9693
EIF4B 2213 1367
EIF4E 8016 7576
EIF4EBP1 6719 6918
EIF4G1 5724 10120
EIF4H 7558 9107
EIF5 1261 4191
EIF5B 5000 -2620
EPRS1 3916 1660
ERAL1 994 238
ETF1 9199 8093
FARS2 2802 -5254
FARSA -1094 3471
FARSB 6124 -2074
FAU -1127 -1637
GADD45GIP1 2005 378
GARS1 9748 9166
GFM1 4888 -3769
GFM2 7651 5825
GSPT1 8890 4650
GSPT2 -5847 -5423
HARS1 -3253 -3345
HARS2 -5840 -2040
IARS1 -7684 -8609
IARS2 8201 7487
KARS1 8005 -2267
LARS1 7998 -4102
LARS2 -5056 -1395
MARS1 -3233 1396
MARS2 -9141 -9167
MRPL1 5472 -2755
MRPL10 -6962 -1479
MRPL11 3734 890
MRPL12 5869 900
MRPL13 8990 5467
MRPL14 4494 -5447
MRPL15 5687 4250
MRPL16 7708 4729
MRPL17 -2940 -8803
MRPL18 6655 3759
MRPL19 6488 4816
MRPL2 -1764 -3998
MRPL20 4686 2223
MRPL21 774 2475
MRPL22 6630 5900
MRPL23 8054 8471
MRPL24 676 -5275
MRPL27 2127 -1096
MRPL28 6970 9066
MRPL3 6339 2917
MRPL30 8725 7479
MRPL32 993 -5141
MRPL33 7614 8247
MRPL34 -1934 -501
MRPL35 5994 -1142
MRPL36 -89 1931
MRPL37 1300 5479
MRPL38 2031 -6342
MRPL39 659 -6904
MRPL4 2917 1022
MRPL40 -3035 -1552
MRPL41 941 -3355
MRPL42 8661 -5375
MRPL43 -3601 -667
MRPL44 9007 5816
MRPL45 8869 2465
MRPL46 -855 -5997
MRPL47 8699 6733
MRPL48 6758 -615
MRPL49 -8361 -6980
MRPL50 7536 -7017
MRPL51 6526 5986
MRPL52 4229 6983
MRPL53 4976 7338
MRPL54 1494 -4985
MRPL55 -5398 -6360
MRPL57 3248 -2033
MRPL58 6634 4107
MRPL9 -8366 -6388
MRPS10 8384 6612
MRPS11 2353 4961
MRPS12 -2506 -2547
MRPS14 2975 1195
MRPS15 3131 4583
MRPS16 6555 5748
MRPS17 1740 -4036
MRPS18A 4120 1503
MRPS18B -1258 -6479
MRPS18C 7007 3024
MRPS2 -2269 -5655
MRPS21 -5301 -5158
MRPS22 8341 5060
MRPS23 7322 1678
MRPS24 2632 3061
MRPS25 -2451 -8866
MRPS26 -7533 -4281
MRPS27 154 -4059
MRPS28 7100 5411
MRPS30 -1675 -6196
MRPS31 923 783
MRPS33 1605 -7402
MRPS34 3806 2770
MRPS35 8160 5251
MRPS36 8813 8233
MRPS5 7858 8027
MRPS6 -5854 -8812
MRPS7 6569 1896
MRPS9 -5654 -5327
MRRF 1262 -4332
MT-RNR1 -4660 -192
MT-RNR2 -4826 4275
MT-TV -8649 -6121
MTFMT -4120 4528
MTIF2 6404 1551
MTIF3 7779 5495
MTRF1L 8079 8761
N6AMT1 -6775 -9870
NARS1 9331 5871
NARS2 -3091 -8477
OXA1L 8459 6936
PABPC1 7203 5354
PARS2 -8672 -4957
PPA1 9593 -2306
PPA2 6902 5273
PTCD3 -7945 -5577
QARS1 -1631 800
RARS1 6167 2457
RARS2 5649 5924
RPL10 631 -5696
RPL10A 1976 -6292
RPL11 1839 -3327
RPL12 2014 -5298
RPL13 2796 -3228
RPL13A -1728 -6706
RPL14 -1317 -5766
RPL15 5748 532
RPL17 143 -3476
RPL18 3381 -4456
RPL18A -1706 -4694
RPL19 -787 -4539
RPL21 276 -3918
RPL22 4761 -1687
RPL22L1 7231 -349
RPL23 3153 -1612
RPL23A -903 -7885
RPL24 1656 -1751
RPL26 842 -3483
RPL26L1 8258 7992
RPL27 1376 -417
RPL27A -1685 -3049
RPL28 2709 -1855
RPL29 1515 -3475
RPL3 -3958 -7454
RPL30 -2576 -5578
RPL31 -429 -3242
RPL32 219 -4702
RPL34 -1732 -6642
RPL35 -9119 -4134
RPL35A -112 -2513
RPL36 -4022 -4235
RPL36A 1606 -4363
RPL36AL 5944 -2052
RPL37 -6271 -3029
RPL37A -2362 -447
RPL38 -4515 -3500
RPL39 2137 350
RPL39L -7572 -3974
RPL4 4738 -2403
RPL41 -1299 -3511
RPL5 4105 -2796
RPL6 4935 -1237
RPL7 5143 -1272
RPL7A 1809 -1927
RPL8 1265 -1924
RPL9 700 -4879
RPLP0 6333 -1009
RPLP1 -1197 916
RPLP2 -4847 -5802
RPN1 8456 8842
RPN2 7659 7805
RPS10 -489 -4974
RPS11 -2316 -5641
RPS12 -4797 -7620
RPS13 5276 -1635
RPS14 -4624 -5393
RPS15 -1754 -3299
RPS15A 1269 -4048
RPS16 -2078 -6063
RPS17 -5045 -3169
RPS18 -7322 -6605
RPS19 -2989 -7057
RPS2 1634 -3308
RPS20 -2911 -6018
RPS21 -1933 -3896
RPS23 772 -4150
RPS24 6586 1001
RPS25 2600 -3817
RPS26 3527 -5041
RPS27 -7168 -6878
RPS27A -1868 -5386
RPS27L 7604 4230
RPS28 -2921 -3626
RPS29 -6817 -4617
RPS3 2486 -5123
RPS3A 5865 -3619
RPS4X -677 -7632
RPS4Y1 3815 574
RPS5 -1017 -5500
RPS6 2176 -3737
RPS7 1946 -2271
RPS8 3760 -769
RPS9 7673 4928
RPSA -3597 -5016
SARS1 496 -3575
SARS2 -8492 -6609
SEC11A 7834 9453
SEC11C 4927 -6276
SEC61A1 8546 7506
SEC61A2 -8294 -8164
SEC61B 9260 8673
SEC61G 8791 5259
SPCS1 7553 4977
SPCS2 7508 4451
SPCS3 7891 5004
SRP14 5097 7759
SRP19 8759 6276
SRP54 9899 8393
SRP68 4756 4519
SRP72 4576 1760
SRP9 9330 5662
SRPRA -235 6430
SRPRB -254 -8543
SSR1 9162 7637
SSR2 7502 2833
SSR3 8865 7729
SSR4 4508 2346
TARS1 6270 6534
TARS2 -6092 -5717
TRAM1 5957 -3682
TRMT112 3035 510
TSFM 9137 4712
TUFM 26 4585
UBA52 2067 260
VARS1 -3603 -3437
VARS2 -3139 -1959
WARS1 3334 -8797
WARS2 6233 -6540
YARS1 -3921 4984
YARS2 -2388 -3459



Regulation of Complement cascade

Regulation of Complement cascade
metric value
setSize 93
pMANOVA 1.3e-19
p.adjustMANOVA 9.59e-18
s.dist 0.366
s.low.CRP 0.174
s.high.CRP -0.322
p.low.CRP 0.0038
p.high.CRP 7.8e-08




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
CFH 4430 -8637
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235

Click HERE to show all gene set members

All member genes
low CRP high CRP
C1QA 2730 7449
C1QB 7676 9366
C1QC 8977 9784
C1R -9046 -4725
C1S -1133 4982
C2 9215 6100
C3 -10957 -10571
C3AR1 8008 9376
C4A 6469 1331
C4B 3894 -2194
C4BPB 2719 -2804
C5 6559 4756
C5AR1 9773 10201
C5AR2 8236 7910
C8G -10359 -8822
CD19 -5755 -965
CD46 7723 3480
CD55 9747 10312
CD59 6386 4199
CD81 -10198 -7220
CFB 4527 1298
CFH 4430 -8637
CLU 8797 10607
CPN2 4742 5903
CR1 10309 10566
CR2 -1369 -1274
ELANE 10082 5779
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
PROS1 8002 7705
SERPING1 533 -10700
VTN 714 1913



rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol
metric value
setSize 189
pMANOVA 1.34e-19
p.adjustMANOVA 9.59e-18
s.dist 0.279
s.low.CRP 0.0661
s.high.CRP -0.271
p.low.CRP 0.117
p.high.CRP 1.3e-10




Top 20 genes
Gene low CRP high CRP
RPP40 7453 -8690
GNL3 6083 -7025
RPP38 5051 -7716
WDR75 4353 -8698
NOP58 4347 -8474
TSR1 4712 -7123
MPHOSPH10 5952 -4333
EMG1 4466 -5473
RPS3A 5865 -3619
UTP15 2657 -7360
EXOSC9 2761 -7072
RPP30 5972 -3194
RPS26 3527 -5041
NOL11 1925 -8448
DIMT1 2279 -6842
RPL18 3381 -4456
EXOSC5 1739 -8095
DDX47 1777 -7672
RPS3 2486 -5123
RPL10A 1976 -6292

Click HERE to show all gene set members

All member genes
low CRP high CRP
BMS1 -5936 -8197
BOP1 -3795 -5762
BYSL -1005 -2393
C1D 6736 4014
CSNK1D -8768 1189
CSNK1E -9314 -5872
DCAF13 327 6103
DDX21 9035 4115
DDX47 1777 -7672
DDX49 3833 4376
DDX52 8089 4089
DHX37 -7195 -4839
DIMT1 2279 -6842
DIS3 1689 -830
DKC1 -4589 -10307
EBNA1BP2 5515 -1375
EMG1 4466 -5473
ERI1 5656 5643
EXOSC1 2885 304
EXOSC10 -6650 -5828
EXOSC2 -3961 -8955
EXOSC3 1418 2162
EXOSC4 5868 7957
EXOSC5 1739 -8095
EXOSC6 -9351 -7944
EXOSC7 -6315 -5278
EXOSC8 -3547 -9913
EXOSC9 2761 -7072
FAU -1127 -1637
FBL -6170 -7357
FCF1 7340 6857
FTSJ3 -4598 507
GAR1 1898 -2266
GNL3 6083 -7025
HEATR1 -5578 -8123
IMP3 -7393 -8684
IMP4 -7848 -9701
ISG20L2 732 5116
KRR1 375 -5095
LAS1L -9410 -9422
LTV1 7672 3314
MPHOSPH10 5952 -4333
MPHOSPH6 5285 7932
MTREX 4323 3278
NAT10 -8029 -9599
NCL -4547 -7597
NHP2 4484 -2384
NIP7 2396 -3614
NOB1 -6895 -7557
NOC4L -6324 -2308
NOL11 1925 -8448
NOL12 6226 5817
NOL6 -7959 -8898
NOL9 -6074 -8704
NOP10 8570 9831
NOP14 -6422 -8870
NOP2 -4106 -6672
NOP56 -5022 -9989
NOP58 4347 -8474
PDCD11 -10108 -7686
PELP1 -2643 -9040
PES1 4862 -993
PNO1 6437 -1058
PWP2 2407 4941
RBM28 -10189 -7366
RCL1 7236 2023
RIOK1 5183 3907
RIOK2 9357 84
RIOK3 9413 9229
RPL10 631 -5696
RPL10A 1976 -6292
RPL11 1839 -3327
RPL12 2014 -5298
RPL13 2796 -3228
RPL13A -1728 -6706
RPL14 -1317 -5766
RPL15 5748 532
RPL17 143 -3476
RPL18 3381 -4456
RPL18A -1706 -4694
RPL19 -787 -4539
RPL21 276 -3918
RPL22 4761 -1687
RPL22L1 7231 -349
RPL23 3153 -1612
RPL23A -903 -7885
RPL24 1656 -1751
RPL26 842 -3483
RPL26L1 8258 7992
RPL27 1376 -417
RPL27A -1685 -3049
RPL28 2709 -1855
RPL29 1515 -3475
RPL3 -3958 -7454
RPL30 -2576 -5578
RPL31 -429 -3242
RPL32 219 -4702
RPL34 -1732 -6642
RPL35 -9119 -4134
RPL35A -112 -2513
RPL36 -4022 -4235
RPL36A 1606 -4363
RPL36AL 5944 -2052
RPL37 -6271 -3029
RPL37A -2362 -447
RPL38 -4515 -3500
RPL39 2137 350
RPL39L -7572 -3974
RPL4 4738 -2403
RPL41 -1299 -3511
RPL5 4105 -2796
RPL6 4935 -1237
RPL7 5143 -1272
RPL7A 1809 -1927
RPL8 1265 -1924
RPL9 700 -4879
RPLP0 6333 -1009
RPLP1 -1197 916
RPLP2 -4847 -5802
RPP14 6153 3856
RPP21 -2599 -4355
RPP25 -6016 -6916
RPP30 5972 -3194
RPP38 5051 -7716
RPP40 7453 -8690
RPS10 -489 -4974
RPS11 -2316 -5641
RPS12 -4797 -7620
RPS13 5276 -1635
RPS14 -4624 -5393
RPS15 -1754 -3299
RPS15A 1269 -4048
RPS16 -2078 -6063
RPS17 -5045 -3169
RPS18 -7322 -6605
RPS19 -2989 -7057
RPS2 1634 -3308
RPS20 -2911 -6018
RPS21 -1933 -3896
RPS23 772 -4150
RPS24 6586 1001
RPS25 2600 -3817
RPS26 3527 -5041
RPS27 -7168 -6878
RPS27A -1868 -5386
RPS27L 7604 4230
RPS28 -2921 -3626
RPS29 -6817 -4617
RPS3 2486 -5123
RPS3A 5865 -3619
RPS4X -677 -7632
RPS4Y1 3815 574
RPS5 -1017 -5500
RPS6 2176 -3737
RPS7 1946 -2271
RPS8 3760 -769
RPS9 7673 4928
RPSA -3597 -5016
RRP1 1558 -5262
RRP36 -39 3862
RRP7A -4975 -3024
RRP9 72 -8148
SENP3 1324 5191
SNORD3A -9792 1193
SNU13 -139 -5644
TBL3 -4163 -4984
TEX10 -728 -6521
THUMPD1 48 -9681
TRMT112 3035 510
TSR1 4712 -7123
TSR3 -1220 3240
UBA52 2067 260
UTP11 8322 6927
UTP14A 2019 2472
UTP14C -713 1477
UTP15 2657 -7360
UTP18 6514 7406
UTP20 -1589 -7369
UTP3 2595 699
UTP4 -736 -9058
UTP6 6320 367
WDR12 7691 8132
WDR18 3545 -3386
WDR3 -1131 -931
WDR36 2502 -1850
WDR43 2464 -3068
WDR46 -6771 -6887
WDR75 4353 -8698
XRN2 10201 10472



Role of LAT2/NTAL/LAB on calcium mobilization

Role of LAT2/NTAL/LAB on calcium mobilization
metric value
setSize 73
pMANOVA 1.98e-19
p.adjustMANOVA 1.3e-17
s.dist 0.426
s.low.CRP 0.15
s.high.CRP -0.399
p.low.CRP 0.0271
p.high.CRP 3.62e-09




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
FYN -10683 -7016
GAB2 6405 10289
GRB2 9960 10389
IGHE -4940 -4979
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
LAT2 8450 9858
LYN 8483 8583
PDPK1 -54 8056
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3R1 -7314 -9108
PIK3R2 2369 6022
SHC1 3101 5292
SOS1 2394 -4661
SYK 9750 10350



Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors
metric value
setSize 91
pMANOVA 2.01e-19
p.adjustMANOVA 1.3e-17
s.dist 0.36
s.low.CRP 0.214
s.high.CRP -0.289
p.low.CRP 0.000413
p.high.CRP 1.92e-06




Top 20 genes
Gene low CRP high CRP
SCARF1 7980 -9211
IGHV3-30 6205 -8897
IGHA1 6020 -8527
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
JCHAIN 5415 -8049
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875

Click HERE to show all gene set members

All member genes
low CRP high CRP
ALB 5157 1598
APOE -4921 3265
APOL1 1106 -9021
CALR 8310 6954
CD163 10141 10559
CD36 10363 10493
COL1A2 4726 5641
COL4A2 -2203 4823
COLEC12 -10027 2954
FTH1 1622 1016
FTL 9418 9788
HBA1 9695 8704
HBB 9671 6093
HP 10242 10523
HPX 2028 -3809
HSP90AA1 5650 1245
HSP90B1 8375 1593
HSPH1 -3822 -6902
HYOU1 -4725 352
IGHA1 6020 -8527
IGHA2 3566 -2966
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
JCHAIN 5415 -8049
LRP1 8118 10314
MARCO 7808 10448
MSR1 -1194 6317
SCARB1 6192 5385
SCARF1 7980 -9211
SCGB3A2 -4719 -668
SPARC 7330 7225
SSC5D -6156 -4021
STAB1 10304 10662
STAB2 6753 7249



Complement cascade

Complement cascade
metric value
setSize 97
pMANOVA 2.43e-19
p.adjustMANOVA 1.51e-17
s.dist 0.356
s.low.CRP 0.169
s.high.CRP -0.313
p.low.CRP 0.00396
p.high.CRP 1e-07




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
CFH 4430 -8637
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235

Click HERE to show all gene set members

All member genes
low CRP high CRP
C1QA 2730 7449
C1QB 7676 9366
C1QC 8977 9784
C1R -9046 -4725
C1S -1133 4982
C2 9215 6100
C3 -10957 -10571
C3AR1 8008 9376
C4A 6469 1331
C4B 3894 -2194
C4BPB 2719 -2804
C5 6559 4756
C5AR1 9773 10201
C5AR2 8236 7910
C8G -10359 -8822
CD19 -5755 -965
CD46 7723 3480
CD55 9747 10312
CD59 6386 4199
CD81 -10198 -7220
CFB 4527 1298
CFD 911 -342
CFH 4430 -8637
CLU 8797 10607
CPN2 4742 5903
CR1 10309 10566
CR2 -1369 -1274
ELANE 10082 5779
FCN1 10313 9522
GZMM -10508 -10275
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
MASP2 836 -2977
PROS1 8002 7705
SERPING1 533 -10700
VTN 714 1913



Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation
metric value
setSize 219
pMANOVA 1.75e-18
p.adjustMANOVA 1.03e-16
s.dist 0.405
s.low.CRP 0.196
s.high.CRP 0.354
p.low.CRP 5.63e-07
p.high.CRP 1.72e-19




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
CD36 10363 10493
PLA2G4A 10226 10618
GNA15 10227 10612
GNG10 10307 10252
CYB5R1 10052 10467
LHFPL2 9993 10508
SERPINA1 10186 10295
QSOX1 9888 10475
GRB2 9960 10389
APLP2 9754 10588
CD63 9814 10489
ALDOA 10140 10121
SYK 9750 10350
APP 10085 9961
STXBP2 9851 10088
FERMT3 9665 10217
MAPK14 10026 9803
GAS6 9599 9997
PIK3CB 9880 9707

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201 6324
A2M -7493 -9192
AAMP -546 -3061
ABCC4 4731 8657
ABHD12 -10547 -6538
ABHD6 -8566 3459
ACTN1 9802 9301
ACTN4 -6751 7995
ADRA2A -4933 4150
AKT1 -5096 2421
ALB 5157 1598
ALDOA 10140 10121
ANXA5 10047 9393
APBB1IP 10051 8873
APLP2 9754 10588
APOOL 6366 5539
APP 10085 9961
ARRB1 -5720 3058
ARRB2 8232 9058
BRPF3 -9645 -6135
CALM1 -4337 1051
CALU 8618 9731
CAP1 9134 8626
CD109 6898 6560
CD36 10363 10493
CD63 9814 10489
CD9 7795 5893
CDC37L1 1694 -5736
CDC42 9246 8570
CFD 911 -342
CFL1 9368 9341
CHID1 1491 3495
CLEC1B 9634 9849
CLEC3B 8957 10039
CLU 8797 10607
CRK 9214 9663
CSK -2015 6501
CTSW -10450 -9076
CYB5R1 10052 10467
DAGLA -9795 -7353
DAGLB -390 9293
DGKA 1996 -8807
DGKD -10564 796
DGKE -5951 -9294
DGKG 9117 9128
DGKH -1070 -250
DGKK -9484 -7897
DGKQ -9702 -6805
DGKZ -8776 -6149
ECM1 8140 6368
EGF 8136 8196
ENDOD1 -3996 3892
F13A1 9500 8453
F2R -10475 -7685
F2RL2 -8189 1891
F2RL3 -5912 4363
F5 10339 10599
F8 7904 8494
FAM3C -5488 -5977
FCER1G 9338 9547
FERMT3 9665 10217
FLNA -8851 2557
FN1 9912 6648
FYN -10683 -7016
GAS6 9599 9997
GNA11 5927 -295
GNA12 3200 3712
GNA13 3919 6618
GNA15 10227 10612
GNAI1 5305 5103
GNAI2 8368 9095
GNAI3 9913 8209
GNAQ 10128 9401
GNB1 7951 9297
GNB2 8365 8530
GNB3 9486 -8169
GNB4 9757 8191
GNB5 -762 -205
GNG10 10307 10252
GNG11 4608 5846
GNG2 -10288 -2836
GNG3 6662 1225
GNG4 -1513 -1627
GNG5 9805 9666
GNG7 -5188 -5336
GNG8 -5154 2284
GNGT2 -10923 -9575
GP1BA 982 6984
GP1BB 1443 8042
GP5 2423 -4169
GP6 1911 8115
GP9 5315 8099
GRB2 9960 10389
GTPBP2 -3289 8058
HABP4 -4596 -10369
HGF 8952 9949
HSPA5 9415 6475
ITGA2B 8831 9692
ITGB3 7696 8680
ITIH3 -1661 -2817
ITIH4 -4505 -2214
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
LAMP2 9626 9234
LAT -8158 -10401
LCK -9185 -10569
LCP2 5338 -3004
LGALS3BP -278 -10598
LHFPL2 9993 10508
LY6G6F 6222 9342
LYN 8483 8583
MAGED2 -5635 1105
MANF 7239 1636
MAPK1 -1086 9427
MAPK14 10026 9803
MAPK3 9769 9676
MGLL 5785 8910
MMRN1 7311 8075
MPL -1282 2589
NHLRC2 -4230 -5211
OLA1 9281 7615
ORM1 9208 6694
ORM2 1731 -2088
P2RY1 -7831 10440
P2RY12 -1550 5827
PCYOX1L 2112 -3420
PDGFA 1176 5657
PDGFB -8368 -7863
PDPK1 -54 8056
PECAM1 7190 9387
PF4 3055 6229
PFN1 1471 6861
PHACTR2 -1263 7436
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3CG -9133 3842
PIK3R1 -7314 -9108
PIK3R2 2369 6022
PIK3R3 -10971 -7175
PIK3R5 -10408 -5867
PIK3R6 6288 8699
PLA2G4A 10226 10618
PLCG2 -6227 6708
PLEK -3117 3467
PLG 299 -2400
PPBP 5440 6001
PPIA 285 1417
PRKCA 2691 1966
PRKCB -4906 9024
PRKCD 9710 9721
PRKCE -10688 -925
PRKCH -10885 -10674
PRKCQ -9967 -10691
PRKCZ -10726 -9780
PROS1 8002 7705
PSAP 8066 8239
PTK2 4992 3213
PTPN1 -7223 8628
PTPN11 3471 9688
PTPN6 3230 7923
QSOX1 9888 10475
RAB27B -6595 4754
RAC1 9345 9946
RAC2 -1305 4460
RAF1 8083 7846
RAP1A 9691 8186
RAP1B -3254 7324
RAPGEF3 -5747 5214
RASGRP1 -9188 -10645
RASGRP2 -6869 -9348
RHOA 9541 9090
RHOB -6176 416
RHOG 8649 8946
SCCPDH 8217 9056
SELENOP 1102 -7075
SELP 8480 9339
SERPINA1 10186 10295
SERPINE1 3011 7764
SERPINF2 -10171 140
SERPING1 533 -10700
SHC1 3101 5292
SOD1 3597 -3501
SOS1 2394 -4661
SPARC 7330 7225
SRC -4936 -8846
SRGN 9966 9137
STX4 -4764 2706
STXBP2 9851 10088
STXBP3 9718 8688
SYK 9750 10350
SYTL4 234 9384
TAGLN2 5738 6791
TBXA2R -1679 4971
TEX264 -9385 -6429
TF 2007 3922
TGFB1 984 3574
TGFB2 -3931 -4176
TGFB3 -6195 -4793
THBS1 1255 9820
TIMP1 6709 10267
TLN1 5974 9916
TMSB4X 3917 6032
TMX3 4031 2865
TOR4A 8478 10155
TRPC3 -8356 -765
TRPC6 -7554 2174
TTN -3218 6253
TUBA4A -92 4474
VAV1 6299 7892
VAV2 -9043 2054
VAV3 -7486 7780
VCL 913 8321
VEGFA 7943 7054
VEGFB -4813 -5745
VTI1B 9366 9447
VWF 3995 7559
WDR1 -627 8316
YWHAZ 7112 6341



Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol
metric value
setSize 179
pMANOVA 2.42e-18
p.adjustMANOVA 1.38e-16
s.dist 0.276
s.low.CRP 0.0668
s.high.CRP -0.268
p.low.CRP 0.123
p.high.CRP 6.03e-10




Top 20 genes
Gene low CRP high CRP
RPP40 7453 -8690
GNL3 6083 -7025
RPP38 5051 -7716
WDR75 4353 -8698
NOP58 4347 -8474
TSR1 4712 -7123
MPHOSPH10 5952 -4333
EMG1 4466 -5473
RPS3A 5865 -3619
UTP15 2657 -7360
EXOSC9 2761 -7072
RPP30 5972 -3194
RPS26 3527 -5041
NOL11 1925 -8448
RPL18 3381 -4456
EXOSC5 1739 -8095
DDX47 1777 -7672
RPS3 2486 -5123
RPL10A 1976 -6292
RPL36AL 5944 -2052

Click HERE to show all gene set members

All member genes
low CRP high CRP
BMS1 -5936 -8197
BOP1 -3795 -5762
BYSL -1005 -2393
C1D 6736 4014
CSNK1D -8768 1189
CSNK1E -9314 -5872
DCAF13 327 6103
DDX21 9035 4115
DDX47 1777 -7672
DDX49 3833 4376
DDX52 8089 4089
DHX37 -7195 -4839
DIS3 1689 -830
EBNA1BP2 5515 -1375
EMG1 4466 -5473
ERI1 5656 5643
EXOSC1 2885 304
EXOSC10 -6650 -5828
EXOSC2 -3961 -8955
EXOSC3 1418 2162
EXOSC4 5868 7957
EXOSC5 1739 -8095
EXOSC6 -9351 -7944
EXOSC7 -6315 -5278
EXOSC8 -3547 -9913
EXOSC9 2761 -7072
FAU -1127 -1637
FBL -6170 -7357
FCF1 7340 6857
FTSJ3 -4598 507
GNL3 6083 -7025
HEATR1 -5578 -8123
IMP3 -7393 -8684
IMP4 -7848 -9701
ISG20L2 732 5116
KRR1 375 -5095
LAS1L -9410 -9422
LTV1 7672 3314
MPHOSPH10 5952 -4333
MPHOSPH6 5285 7932
MTREX 4323 3278
NCL -4547 -7597
NIP7 2396 -3614
NOB1 -6895 -7557
NOC4L -6324 -2308
NOL11 1925 -8448
NOL12 6226 5817
NOL6 -7959 -8898
NOL9 -6074 -8704
NOP14 -6422 -8870
NOP56 -5022 -9989
NOP58 4347 -8474
PDCD11 -10108 -7686
PELP1 -2643 -9040
PES1 4862 -993
PNO1 6437 -1058
PWP2 2407 4941
RBM28 -10189 -7366
RCL1 7236 2023
RIOK1 5183 3907
RIOK2 9357 84
RIOK3 9413 9229
RPL10 631 -5696
RPL10A 1976 -6292
RPL11 1839 -3327
RPL12 2014 -5298
RPL13 2796 -3228
RPL13A -1728 -6706
RPL14 -1317 -5766
RPL15 5748 532
RPL17 143 -3476
RPL18 3381 -4456
RPL18A -1706 -4694
RPL19 -787 -4539
RPL21 276 -3918
RPL22 4761 -1687
RPL22L1 7231 -349
RPL23 3153 -1612
RPL23A -903 -7885
RPL24 1656 -1751
RPL26 842 -3483
RPL26L1 8258 7992
RPL27 1376 -417
RPL27A -1685 -3049
RPL28 2709 -1855
RPL29 1515 -3475
RPL3 -3958 -7454
RPL30 -2576 -5578
RPL31 -429 -3242
RPL32 219 -4702
RPL34 -1732 -6642
RPL35 -9119 -4134
RPL35A -112 -2513
RPL36 -4022 -4235
RPL36A 1606 -4363
RPL36AL 5944 -2052
RPL37 -6271 -3029
RPL37A -2362 -447
RPL38 -4515 -3500
RPL39 2137 350
RPL39L -7572 -3974
RPL4 4738 -2403
RPL41 -1299 -3511
RPL5 4105 -2796
RPL6 4935 -1237
RPL7 5143 -1272
RPL7A 1809 -1927
RPL8 1265 -1924
RPL9 700 -4879
RPLP0 6333 -1009
RPLP1 -1197 916
RPLP2 -4847 -5802
RPP14 6153 3856
RPP21 -2599 -4355
RPP25 -6016 -6916
RPP30 5972 -3194
RPP38 5051 -7716
RPP40 7453 -8690
RPS10 -489 -4974
RPS11 -2316 -5641
RPS12 -4797 -7620
RPS13 5276 -1635
RPS14 -4624 -5393
RPS15 -1754 -3299
RPS15A 1269 -4048
RPS16 -2078 -6063
RPS17 -5045 -3169
RPS18 -7322 -6605
RPS19 -2989 -7057
RPS2 1634 -3308
RPS20 -2911 -6018
RPS21 -1933 -3896
RPS23 772 -4150
RPS24 6586 1001
RPS25 2600 -3817
RPS26 3527 -5041
RPS27 -7168 -6878
RPS27A -1868 -5386
RPS27L 7604 4230
RPS28 -2921 -3626
RPS29 -6817 -4617
RPS3 2486 -5123
RPS3A 5865 -3619
RPS4X -677 -7632
RPS4Y1 3815 574
RPS5 -1017 -5500
RPS6 2176 -3737
RPS7 1946 -2271
RPS8 3760 -769
RPS9 7673 4928
RPSA -3597 -5016
RRP1 1558 -5262
RRP36 -39 3862
RRP7A -4975 -3024
RRP9 72 -8148
SENP3 1324 5191
SNORD3A -9792 1193
SNU13 -139 -5644
TBL3 -4163 -4984
TEX10 -728 -6521
TSR1 4712 -7123
UBA52 2067 260
UTP11 8322 6927
UTP14A 2019 2472
UTP14C -713 1477
UTP15 2657 -7360
UTP18 6514 7406
UTP20 -1589 -7369
UTP3 2595 699
UTP4 -736 -9058
UTP6 6320 367
WDR12 7691 8132
WDR18 3545 -3386
WDR3 -1131 -931
WDR36 2502 -1850
WDR43 2464 -3068
WDR46 -6771 -6887
WDR75 4353 -8698
XRN2 10201 10472



Asparagine N-linked glycosylation

Asparagine N-linked glycosylation
metric value
setSize 269
pMANOVA 1.43e-17
p.adjustMANOVA 7.8e-16
s.dist 0.387
s.low.CRP 0.243
s.high.CRP 0.302
p.low.CRP 7.07e-12
p.high.CRP 1.48e-17




Top 20 genes
Gene low CRP high CRP
CTSA 10310 10636
F5 10339 10599
NPL 10251 10671
ASGR2 9976 10675
SERPINA1 10186 10295
ARF4 10147 10254
ASGR1 10213 10074
CTSZ 9796 10451
KDELR1 9879 10352
CMAS 9980 10161
RAB1A 10223 9909
CD55 9747 10312
NEU1 9609 10026
OS9 9572 10053
GLB1 9395 10125
DCTN2 9097 10370
FUCA1 9326 10044
ARF1 9085 10196
B4GALT5 9525 9637
DCTN6 9751 9405

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACTR10 9447 8995
ACTR1A 1291 7735
ALG1 -7518 -4565
ALG10 -9295 -2926
ALG10B 2640 -6554
ALG11 -4114 415
ALG12 -1788 -1158
ALG13 1354 -7430
ALG14 9158 8578
ALG2 6463 2704
ALG3 5995 -2482
ALG5 7403 2248
ALG6 7443 7333
ALG8 7380 705
ALG9 -3668 -3824
AMDHD2 -10379 -9214
AMFR 9169 6554
ANK1 9056 9344
ANK3 5423 -4595
ANKRD28 -8321 -2586
ARCN1 4291 7676
AREG -5505 9162
ARF1 9085 10196
ARF3 7124 9257
ARF4 10147 10254
ARF5 8080 9476
ARFGAP1 -2066 -296
ARFGAP2 -7117 -3644
ARFGAP3 2322 4136
ASGR1 10213 10074
ASGR2 9976 10675
B4GALNT2 -4045 2852
B4GALT1 -3872 6820
B4GALT2 -2272 31
B4GALT3 -7395 -8398
B4GALT4 -6517 3566
B4GALT5 9525 9637
B4GALT6 -10803 131
BET1 6957 1985
BET1L -4965 -5604
CALR 8310 6954
CANX 7507 7257
CAPZA1 9332 9316
CAPZA2 10077 9039
CAPZB 8393 8843
CD55 9747 10312
CD59 6386 4199
CHST10 -10642 -7986
CHST8 189 6510
CMAS 9980 10161
CNIH1 9266 8825
CNIH2 2506 2667
CNIH3 -9428 -8506
COG1 -9533 -9241
COG2 3963 1728
COG3 3114 -4075
COG4 -3232 889
COG5 3937 3634
COG6 1615 -87
COG7 7042 7599
COG8 -5751 -901
COL7A1 -442 8394
COPA 6851 10178
COPB1 9548 8670
COPB2 9499 8940
COPE 5686 8054
COPG1 7245 9390
COPG2 8584 9972
COPZ1 8315 6558
COPZ2 -2992 -9775
CSNK1D -8768 1189
CTSA 10310 10636
CTSC -3910 5638
CTSZ 9796 10451
DAD1 7699 6258
DCTN1 -4701 7431
DCTN2 9097 10370
DCTN3 3675 7530
DCTN4 5909 10148
DCTN5 -6881 5731
DCTN6 9751 9405
DDOST 5768 8734
DERL1 -5393 -6496
DERL2 5626 4860
DHDDS -6182 1919
DOLK -7816 -482
DOLPP1 7664 3611
DPAGT1 6371 3303
DPM1 5700 4181
DPM2 5599 2835
DPM3 3402 1010
DYNC1H1 -9811 -4718
DYNC1I1 378 6338
DYNC1I2 8978 9397
DYNC1LI1 8227 7194
DYNC1LI2 909 7271
DYNLL1 6414 7208
DYNLL2 -5827 -2261
EDEM1 658 3626
EDEM2 9361 9706
EDEM3 9140 9891
ENGASE -7259 -6058
F5 10339 10599
F8 7904 8494
FCSK 938 372
FPGT 8920 7632
FUCA1 9326 10044
FUOM 2246 -6791
FUT8 -9860 -5220
GANAB -7302 2200
GBF1 -8195 348
GFPT1 -648 -5626
GFPT2 -10443 -7593
GLB1 9395 10125
GMDS 6596 6467
GMPPA 5689 5696
GMPPB -2532 -5077
GNE 1982 -5161
GNPNAT1 5088 -9980
GOLGA2 -6652 7914
GOLGB1 -5170 -2548
GORASP1 8524 6879
GOSR1 -5651 3364
GOSR2 -1757 3596
KDELR1 9879 10352
KDELR2 9893 7875
KDELR3 -1354 -6629
LMAN1 -2101 -9736
LMAN2 6893 7688
LMAN2L 7489 7830
MAGT1 4037 5258
MAN1A1 6497 9657
MAN1A2 -6602 1179
MAN1B1 -3746 -4312
MAN1C1 1396 -8830
MAN2A1 1336 -1270
MAN2A2 -4209 7794
MANEA 7385 -2869
MARCHF6 -6986 224
MCFD2 7974 9249
MGAT1 362 7982
MGAT2 -3625 2214
MGAT3 174 -9979
MGAT4A -482 -6981
MGAT4B 9034 9077
MGAT4C 1409 -1128
MGAT5 -8963 1454
MIA2 6400 5836
MIA3 40 -2504
MLEC -220 4725
MOGS -5070 -3156
MPDU1 8992 9338
MPI -2165 -8742
MVD -7748 -625
NAGK 7844 -141
NANP -8888 -3104
NANS 9209 8150
NAPA 4940 2147
NAPB -4472 1066
NAPG 5219 7040
NEU1 9609 10026
NEU3 -5831 -3117
NGLY1 2029 1344
NPL 10251 10671
NSF 8767 10358
NUDT14 4308 -5033
NUS1 9633 9296
OS9 9572 10053
PDIA3 7841 5995
PGM3 3949 1433
PMM1 -289 4354
PMM2 8358 -635
PPP6C 9263 7953
PPP6R1 -4291 7176
PPP6R3 1461 4805
PREB 4312 7535
PRKCSH 1054 6027
PSMC1 7220 8544
RAB1A 10223 9909
RAB1B 8291 9474
RAD23B 9300 9828
RENBP 6010 7004
RFT1 6431 989
RNF103 -9664 -3083
RNF139 541 907
RNF185 6388 8065
RNF5 -7305 -918
RPN1 8456 8842
RPN2 7659 7805
RPS27A -1868 -5386
SAR1B 9412 8914
SCFD1 6826 7619
SEC13 6324 5321
SEC16A -6613 6860
SEC16B -340 3720
SEC22A 5519 1741
SEC22B 9017 4952
SEC22C 2177 1557
SEC23A 8250 8136
SEC23IP 6616 2151
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SEC31A 1943 6528
SEL1L 6263 8390
SERPINA1 10186 10295
SLC17A5 5214 7726
SLC35A1 9584 8867
SLC35C1 -420 442
SPTA1 9220 7274
SPTAN1 -10045 -9563
SPTB 9406 9121
SPTBN1 -8781 -6351
SPTBN2 -6201 -2780
SPTBN5 -7032 -3485
SRD5A3 7881 1403
ST3GAL1 -7981 -6569
ST3GAL2 7602 9502
ST3GAL3 -1028 2393
ST3GAL4 -9447 4972
ST3GAL5 -6579 -9119
ST3GAL6 9322 5613
ST6GAL1 -10455 -8619
ST6GAL2 -1637 4319
ST6GALNAC1 4074 -8373
ST6GALNAC2 6173 3933
ST6GALNAC3 7932 10316
ST6GALNAC4 -8293 105
ST6GALNAC6 -10568 -10104
ST8SIA1 -1213 -9032
ST8SIA4 8757 9211
ST8SIA5 -1730 5154
ST8SIA6 -10591 -7843
STT3A 6910 6477
STX17 -2656 -9125
STX5 6777 7536
SYVN1 25 3387
TBC1D20 -5268 1442
TFG 9720 8105
TGFA 5895 9650
TMED10 4984 4383
TMED2 6691 7410
TMED3 3770 4652
TMED7 9644 9106
TMED9 7191 9462
TMEM115 3217 3929
TRAPPC1 6932 9117
TRAPPC10 -10367 -4001
TRAPPC2 -9388 -4103
TRAPPC2L 4084 340
TRAPPC3 8513 8500
TRAPPC4 -6015 -5250
TRAPPC5 -685 471
TRAPPC6A -1341 -9288
TRAPPC6B 6911 6051
TRAPPC9 3787 8190
TRIM13 1180 1925
TSTA3 6850 5442
UAP1 -9713 -9507
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UBXN1 -4500 2432
UGGT1 364 6869
UGGT2 9481 7067
USO1 8607 7741
VCP 7591 6702
YKT6 1766 6226



FCERI mediated NF-kB activation

FCERI mediated NF-kB activation
metric value
setSize 136
pMANOVA 3.65e-17
p.adjustMANOVA 1.89e-15
s.dist 0.3
s.low.CRP 0.288
s.high.CRP -0.0861
p.low.CRP 6.79e-09
p.high.CRP 0.0832




Top 20 genes
Gene low CRP high CRP
CUL1 7475 -10175
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
PSME2 3614 -10267
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
PSMA5 6009 -5256
PSMA3 8811 -3545
PSMB8 5148 -5793
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253

Click HERE to show all gene set members

All member genes
low CRP high CRP
BCL10 6535 3786
BTRC -7062 1812
CARD11 -10821 -9353
CDC34 7794 8739
CHUK 9608 9191
CUL1 7475 -10175
FBXW11 3233 8725
IGHE -4940 -4979
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
IKBKB -6356 -1160
IKBKG -595 7203
LYN 8483 8583
MALT1 -1899 -9188
MAP3K7 2469 7237
NFKB1 8527 5403
NFKBIA 8114 5809
PDPK1 -54 8056
PRKCQ -9967 -10691
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
RASGRP1 -9188 -10645
RASGRP2 -6869 -9348
RASGRP4 10117 10286
RELA -2847 -1359
RPS27A -1868 -5386
SEM1 5210 6938
SKP1 8911 4204
TAB1 7080 3716
TAB2 8556 6836
TAB3 215 4794
TRAF6 -4471 1582
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UBE2D1 10262 10093
UBE2D2 5413 5174
UBE2N 7813 4195
UBE2V1 8249 8108



Role of phospholipids in phagocytosis

Role of phospholipids in phagocytosis
metric value
setSize 87
pMANOVA 3.75e-17
p.adjustMANOVA 1.89e-15
s.dist 0.401
s.low.CRP 0.0544
s.high.CRP -0.397
p.low.CRP 0.381
p.high.CRP 1.45e-10




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
AHCYL1 4949 8470
CD247 -10994 -10515
CD3G -8283 -10568
FCGR1A 10365 10249
FCGR2A 9647 9000
FCGR3A -11031 -7169
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3R1 -7314 -9108
PIK3R2 2369 6022
PLA2G6 -10438 -10350
PLCG1 -5836 -10187
PLCG2 -6227 6708
PLD1 10119 10572
PLD2 6138 9091
PLD3 8046 6488
PLD4 -11002 -10493
PLPP5 -9164 -5630
PRKCD 9710 9721
PRKCE -10688 -925
SYK 9750 10350



Signaling by Receptor Tyrosine Kinases

Signaling by Receptor Tyrosine Kinases
metric value
setSize 408
pMANOVA 6.64e-17
p.adjustMANOVA 3.23e-15
s.dist 0.288
s.low.CRP 0.144
s.high.CRP 0.249
p.low.CRP 5.5e-07
p.high.CRP 6.16e-18




Top 20 genes
Gene low CRP high CRP
WASF1 10267 10673
ATP6V0A1 10207 10551
GRB10 10276 10479
DUSP3 10238 10410
CYFIP1 10019 10571
PRKACA 9995 10558
ATP6V1A 10093 10441
CTNNA1 9901 10587
NCF2 10167 10265
ATP6V0D1 10069 10341
TNS3 10126 10220
GRB2 9960 10389
NCSTN 9915 10361
ATP6V1B2 10130 10122
NCF4 10090 10097
CYBB 10294 9839
FES 9561 10580
MEMO1 9973 10096
ADAM10 9652 10284
ATP6V1D 9919 9993

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAMP -546 -3061
ABI1 7076 8607
ABI2 -8604 -8517
ADAM10 9652 10284
ADAM12 1487 -6520
ADAM17 4487 10398
ADAP1 5757 9337
ADORA2A -1381 -1440
AHCYL1 4949 8470
AKT1 -5096 2421
AKT2 -7693 3004
AKT3 -8346 -9755
ANOS1 5298 8339
AP2A1 -5326 9611
AP2A2 5529 9467
AP2B1 -8369 3155
AP2M1 7928 9269
AP2S1 8593 9630
APH1A 3292 4183
APH1B 5962 8800
APOE -4921 3265
AREG -5505 9162
ARF6 -772 2507
ARHGEF7 -9779 4261
ATF1 9088 8764
ATF2 8316 2303
ATP6AP1 4019 10005
ATP6V0A1 10207 10551
ATP6V0A2 -10746 -8412
ATP6V0B 9087 9653
ATP6V0C 9621 9869
ATP6V0D1 10069 10341
ATP6V0E1 8986 9188
ATP6V0E2 -4949 -10370
ATP6V1A 10093 10441
ATP6V1B2 10130 10122
ATP6V1C1 10266 9394
ATP6V1C2 -1408 -231
ATP6V1D 9919 9993
ATP6V1E1 9071 8178
ATP6V1E2 9253 5767
ATP6V1F 8059 6808
ATP6V1G1 7364 3710
ATP6V1G2 -3663 -8648
ATP6V1H 8628 8476
AXL -10913 -9565
BAIAP2 -5772 -4014
BAX 6346 6448
BRAF -5814 3049
BRK1 5824 7761
CALM1 -4337 1051
CAV1 1798 -1413
CBL 1852 8579
CDC37 2418 5331
CDC42 9246 8570
CDK5 9150 10447
CDK5R1 -3681 4421
CHD4 -9329 -2257
CHEK1 5702 -3830
CILP -2633 -10014
CLTA 9206 9264
CLTC 9482 10359
COL4A2 -2203 4823
COL4A3 -3308 2359
COL4A4 -4580 1101
COL6A1 1098 -4933
COL6A2 -10262 -8642
COL6A3 8171 2868
COL9A2 -10365 -5048
COL9A3 9376 5845
CREB1 2938 -595
CRK 9214 9663
CRKL -1879 4224
CSK -2015 6501
CTNNA1 9901 10587
CTNNB1 1446 7186
CTNND1 -511 -4113
CUL5 8446 4656
CYBA 5409 8122
CYBB 10294 9839
CYFIP1 10019 10571
CYFIP2 -10388 -8406
DIAPH1 -9285 3050
DLG4 9782 9451
DNAL4 3405 3820
DNM1 5661 -1028
DNM2 -2349 6839
DNM3 1942 8165
DOCK1 2337 9856
DOCK3 3341 -6755
DOCK7 -2076 -2321
DUSP3 10238 10410
DUSP4 -3900 -8336
DUSP6 7156 -2241
DUSP7 -5905 -3113
EGF 8136 8196
EGR1 7178 6141
EGR2 5175 -1833
EGR3 -434 770
ELK1 5371 2922
ELMO1 3674 6433
ELMO2 -6937 7218
EP300 -2315 7280
EPN1 5311 9662
EPS15 5113 6773
EPS15L1 -9182 2731
ERBB2 -11003 -9975
ERBB3 -597 1233
ERBIN -1073 2273
EREG -2190 5005
ESR1 -6841 -8227
ESRP2 -8215 -6062
FER 5046 1870
FES 9561 10580
FGF2 8825 5391
FGF22 -4199 -8205
FGF23 1297 -7622
FGF7 -1811 -5146
FGF9 -7810 -8061
FGFBP2 -11021 -9906
FGFBP3 -6257 -7616
FGFR1 -9793 -95
FGFR2 -10432 -10034
FGFR4 -1488 -4510
FGFRL1 -10343 -8295
FLRT2 -2193 -3379
FLT1 5294 9048
FLT3 -1564 9968
FLT3LG 4903 -10389
FLT4 -9729 -9204
FOS 7518 2641
FOSB 930 -6572
FOSL1 9964 9367
FRS2 52 35
FRS3 9115 9931
FURIN 7688 10324
FYN -10683 -7016
GAB1 3626 8241
GAB2 6405 10289
GABRB3 -335 -181
GABRG2 6040 -174
GALNT3 -5321 762
GFAP 6411 6766
GGA3 564 5909
GRAP -1421 -10048
GRAP2 -2556 4557
GRB10 10276 10479
GRB2 9960 10389
GTF2F1 -4830 5852
GTF2F2 7868 6958
HBEGF -922 4467
HGF 8952 9949
HGS 813 5448
HNRNPA1 3354 397
HNRNPF 5903 5564
HNRNPH1 1972 -6223
HNRNPM 6832 5561
HRAS 2906 -3843
HSP90AA1 5650 1245
HSPB1 2287 921
ID1 -4311 7412
ID2 -10964 -4657
ID3 -9464 -7014
IGF1R -505 3729
INSR 6229 10310
IRS1 1115 1691
IRS2 3826 10432
ITCH -3904 5799
ITGA2 4859 -2582
ITGA3 -5445 -9086
ITGAV 4141 7107
ITGB1 -332 1996
ITGB3 7696 8680
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
JAK2 8894 -2339
JUNB 7420 5447
JUND -1022 -5794
JUP -10174 -7667
KIDINS220 3495 8272
KIT -10558 -7492
KL 5898 10387
KRAS 4388 5328
LAMA1 -593 5278
LAMA2 -10710 -6242
LAMA4 -4832 3441
LAMA5 832 -94
LAMB1 -362 9598
LAMB2 -7353 -2442
LAMB3 2077 6000
LAMC1 7484 10634
LAMC3 2300 -4489
LCK -9185 -10569
LRIG1 -3350 -10151
LYL1 6663 8727
LYN 8483 8583
MAP2K1 8861 10365
MAP2K2 4832 6767
MAP2K5 3289 6084
MAPK1 -1086 9427
MAPK11 8895 6888
MAPK12 5297 -5399
MAPK13 -7306 -466
MAPK14 10026 9803
MAPK3 9769 9676
MAPK7 -9798 3379
MAPKAP1 7373 6742
MAPKAPK2 -10648 4888
MAPKAPK3 7908 10021
MATK -10976 -10513
MEF2A 8559 9073
MEF2C 5395 -197
MEF2D -9927 -3220
MEMO1 9973 10096
MKNK1 9615 8634
MLST8 308 1090
MMP9 8967 1371
MST1 -7025 2970
MST1R -5128 -7481
MTOR -10624 -2672
MUC20 3464 -5169
MXD4 -10895 -8968
NAB1 8717 1890
NAB2 -9919 -7373
NCBP1 2967 -1011
NCBP2 6179 -5809
NCF1 7986 3322
NCF2 10167 10265
NCF4 10090 10097
NCK1 -8084 -8497
NCK2 -5824 4434
NCKAP1 2316 10142
NCKAP1L 1901 10162
NCOR1 -1531 9348
NCSTN 9915 10361
NEDD4 -1574 7147
NELFB -5387 1018
NOS3 7751 -4608
NRAS 8582 7708
NRG1 7105 -2454
NRG4 4405 4
NRP1 -7972 -5185
NRP2 -1731 -7406
NTRK1 -6360 -10587
PAG1 1967 6079
PAK1 10129 7653
PAK2 9098 8874
PAK3 -1475 -334
PCSK5 1198 7008
PCSK6 8733 9709
PDE3B -9089 -10606
PDGFA 1176 5657
PDGFB -8368 -7863
PDGFC 109 4670
PDGFD -10930 -8800
PDGFRA -825 7909
PDGFRB -10542 -8788
PDPK1 -54 8056
PGF -9085 -3495
PIK3C3 4588 3248
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3R1 -7314 -9108
PIK3R2 2369 6022
PIK3R3 -10971 -7175
PIK3R4 -624 -83
PLAT 5536 -2047
PLCG1 -5836 -10187
PLG 299 -2400
POLR2A -9475 -260
POLR2B 296 2423
POLR2C 3736 -612
POLR2D 6248 -1802
POLR2E 8013 8218
POLR2F 320 5451
POLR2G 1642 5704
POLR2H 4812 -2703
POLR2I 2083 1475
POLR2J 7302 8189
POLR2K 7511 2990
POLR2L 2955 6234
PPP2CA 9766 8577
PPP2CB 9136 9093
PPP2R1A 1997 5379
PPP2R1B 3691 1706
PPP2R5D -5620 3209
PRKACA 9995 10558
PRKACB -8479 -10448
PRKCA 2691 1966
PRKCB -4906 9024
PRKCD 9710 9721
PRKCE -10688 -925
PRKCZ -10726 -9780
PRR5 -10901 -10359
PSEN1 7406 9055
PSEN2 -2616 -7755
PSENEN 8280 7751
PTBP1 -753 1627
PTK2 4992 3213
PTK2B 2160 9588
PTK6 7972 8367
PTPN1 -7223 8628
PTPN11 3471 9688
PTPN12 6377 9874
PTPN18 -3234 9001
PTPN2 8577 10537
PTPN3 -1234 2091
PTPN6 3230 7923
PTPRJ 1010 9383
PTPRK -8535 -6991
PTPRO 5327 6304
PTPRS -10959 -8229
PTPRU 415 -1928
PXN -1154 6730
RAB4A 8673 6735
RAB4B -3971 4641
RAC1 9345 9946
RALA 8746 2764
RALB 9778 8653
RALGDS -10755 -9889
RANBP10 -4299 3329
RANBP9 802 6559
RAP1A 9691 8186
RAP1B -3254 7324
RAPGEF1 -10785 -4187
RASA1 -703 7613
RBFOX2 -6643 -4561
REST -3978 3460
RHOA 9541 9090
RICTOR -7204 -8306
RIT1 9776 10016
RNF41 6643 9620
ROCK1 5871 8890
ROCK2 2896 8362
RPS27A -1868 -5386
RPS6KA1 1245 8996
RPS6KA2 -5842 2331
RPS6KA3 1034 3942
RPS6KA5 70 -10393
S100B -10129 814
SGK1 8332 -90
SH2B2 2514 9954
SH2B3 -65 4784
SH2D2A -10864 -10426
SH3GL1 6353 8238
SH3KBP1 2654 6905
SHB -4040 6202
SHC1 3101 5292
SHC3 9069 -1064
SOCS1 8467 6659
SOCS6 8062 10245
SOS1 2394 -4661
SPARC 7330 7225
SPHK1 8695 8421
SPINT1 8074 9078
SPINT2 8306 8806
SPRED1 -8378 -3713
SPRED2 -2639 8478
SPRY1 -4758 1080
SPRY2 -8767 514
SRC -4936 -8846
SRF 4327 6929
STAM 2880 1495
STAM2 8313 7133
STAT1 -3982 -10718
STAT3 9401 8593
STAT5A 8323 7832
STAT5B 4680 4956
STAT6 195 7872
STMN1 -3862 -6746
STUB1 -5098 -1439
TAB2 8556 6836
TCF12 -3191 6334
TCIRG1 253 9871
TEC 6790 9842
TF 2007 3922
TGFA 5895 9650
THBS1 1255 9820
THBS3 9211 8379
THBS4 -1756 -6936
THEM4 -1580 -10466
TIA1 1543 -2965
TIAL1 6466 1156
TIAM1 3669 -4480
TLR9 -10559 -4710
TNS3 10126 10220
TNS4 -851 1590
TPH1 4060 -6005
TRIB1 6930 8686
TRIB3 -7114 -4878
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
USP8 8356 8962
VAV1 6299 7892
VAV2 -9043 2054
VAV3 -7486 7780
VEGFA 7943 7054
VEGFB -4813 -5745
VRK3 -2450 3426
WASF1 10267 10673
WASF2 6329 9933
WASF3 5357 6353
WWOX -10546 -6071
WWP1 333 -9676
YES1 -10892 -9337
YWHAB 9116 6191



ER to Golgi Anterograde Transport

ER to Golgi Anterograde Transport
metric value
setSize 129
pMANOVA 4.01e-16
p.adjustMANOVA 1.88e-14
s.dist 0.522
s.low.CRP 0.304
s.high.CRP 0.424
p.low.CRP 2.52e-09
p.high.CRP 8.03e-17




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
SERPINA1 10186 10295
ARF4 10147 10254
CTSZ 9796 10451
KDELR1 9879 10352
RAB1A 10223 9909
CD55 9747 10312
DCTN2 9097 10370
ARF1 9085 10196
DCTN6 9751 9405
CAPZA2 10077 9039
NSF 8767 10358
TMED7 9644 9106
CAPZA1 9332 9316
SPTB 9406 9121
COPG2 8584 9972
ACTR10 9447 8995
COPB2 9499 8940
ANK1 9056 9344
DYNC1I2 8978 9397

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACTR10 9447 8995
ACTR1A 1291 7735
ANK1 9056 9344
ANK3 5423 -4595
ANKRD28 -8321 -2586
ARCN1 4291 7676
AREG -5505 9162
ARF1 9085 10196
ARF3 7124 9257
ARF4 10147 10254
ARF5 8080 9476
ARFGAP1 -2066 -296
ARFGAP2 -7117 -3644
ARFGAP3 2322 4136
BET1 6957 1985
BET1L -4965 -5604
CAPZA1 9332 9316
CAPZA2 10077 9039
CAPZB 8393 8843
CD55 9747 10312
CD59 6386 4199
CNIH1 9266 8825
CNIH2 2506 2667
CNIH3 -9428 -8506
COG1 -9533 -9241
COG2 3963 1728
COG3 3114 -4075
COG4 -3232 889
COG5 3937 3634
COG6 1615 -87
COG7 7042 7599
COG8 -5751 -901
COL7A1 -442 8394
COPA 6851 10178
COPB1 9548 8670
COPB2 9499 8940
COPE 5686 8054
COPG1 7245 9390
COPG2 8584 9972
COPZ1 8315 6558
COPZ2 -2992 -9775
CSNK1D -8768 1189
CTSC -3910 5638
CTSZ 9796 10451
DCTN1 -4701 7431
DCTN2 9097 10370
DCTN3 3675 7530
DCTN4 5909 10148
DCTN5 -6881 5731
DCTN6 9751 9405
DYNC1H1 -9811 -4718
DYNC1I1 378 6338
DYNC1I2 8978 9397
DYNC1LI1 8227 7194
DYNC1LI2 909 7271
DYNLL1 6414 7208
DYNLL2 -5827 -2261
F5 10339 10599
F8 7904 8494
GBF1 -8195 348
GOLGA2 -6652 7914
GOLGB1 -5170 -2548
GORASP1 8524 6879
GOSR1 -5651 3364
GOSR2 -1757 3596
KDELR1 9879 10352
KDELR2 9893 7875
KDELR3 -1354 -6629
LMAN1 -2101 -9736
LMAN2 6893 7688
LMAN2L 7489 7830
MCFD2 7974 9249
MIA2 6400 5836
MIA3 40 -2504
NAPA 4940 2147
NAPB -4472 1066
NAPG 5219 7040
NSF 8767 10358
PPP6C 9263 7953
PPP6R1 -4291 7176
PPP6R3 1461 4805
PREB 4312 7535
RAB1A 10223 9909
RAB1B 8291 9474
SAR1B 9412 8914
SCFD1 6826 7619
SEC13 6324 5321
SEC16A -6613 6860
SEC16B -340 3720
SEC22A 5519 1741
SEC22B 9017 4952
SEC22C 2177 1557
SEC23A 8250 8136
SEC23IP 6616 2151
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SEC31A 1943 6528
SERPINA1 10186 10295
SPTA1 9220 7274
SPTAN1 -10045 -9563
SPTB 9406 9121
SPTBN1 -8781 -6351
SPTBN2 -6201 -2780
SPTBN5 -7032 -3485
STX17 -2656 -9125
STX5 6777 7536
TBC1D20 -5268 1442
TFG 9720 8105
TGFA 5895 9650
TMED10 4984 4383
TMED2 6691 7410
TMED3 3770 4652
TMED7 9644 9106
TMED9 7191 9462
TMEM115 3217 3929
TRAPPC1 6932 9117
TRAPPC10 -10367 -4001
TRAPPC2 -9388 -4103
TRAPPC2L 4084 340
TRAPPC3 8513 8500
TRAPPC4 -6015 -5250
TRAPPC5 -685 471
TRAPPC6A -1341 -9288
TRAPPC6B 6911 6051
TRAPPC9 3787 8190
USO1 8607 7741
YKT6 1766 6226



Interleukin-1 signaling

Interleukin-1 signaling
metric value
setSize 97
pMANOVA 4.68e-16
p.adjustMANOVA 2.13e-14
s.dist 0.619
s.low.CRP 0.467
s.high.CRP 0.406
p.low.CRP 1.77e-15
p.high.CRP 4.61e-12




Top 20 genes
Gene low CRP high CRP
S100A12 10367 10617
IL1RN 10354 9802
APP 10085 9961
NKIRAS2 9577 10434
IRAK3 9582 10412
PSMD6 9864 9375
MAP2K1 8861 10365
CHUK 9608 9191
MAP2K6 8704 10103
NOD2 9289 9320
IL1R1 8837 9561
PSMB7 9346 8950
PSMA1 9165 8953
PSME3 9544 8452
PSMD12 9648 8351
PSMD4 8627 9334
PSMD11 8697 9183
PSMC6 9832 7978
PSMB5 8225 9508
PSMD1 8509 8974

Click HERE to show all gene set members

All member genes
low CRP high CRP
AGER 1815 2573
APP 10085 9961
BTRC -7062 1812
CHUK 9608 9191
CUL1 7475 -10175
FBXW11 3233 8725
HMGB1 3409 1050
IKBKB -6356 -1160
IKBKG -595 7203
IL1B 9843 323
IL1R1 8837 9561
IL1R2 7717 2515
IL1RAP -137 7646
IL1RN 10354 9802
IRAK1 2858 6473
IRAK2 -10838 -5931
IRAK3 9582 10412
MAP2K1 8861 10365
MAP2K4 5525 7430
MAP2K6 8704 10103
MAP3K3 6459 9695
MAP3K7 2469 7237
MAP3K8 -7148 10028
MYD88 8926 8524
NFKB1 8527 5403
NFKB2 5450 -6553
NFKBIA 8114 5809
NFKBIB -5904 1139
NKIRAS1 1465 2281
NKIRAS2 9577 10434
NOD1 -10556 -9537
NOD2 9289 9320
PELI1 8918 5667
PELI2 7349 9515
PELI3 -320 9317
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
RBX1 1119 4750
RELA -2847 -1359
RIPK2 8675 2009
RPS27A -1868 -5386
S100A12 10367 10617
S100B -10129 814
SEM1 5210 6938
SKP1 8911 4204
SQSTM1 5451 -188
TAB1 7080 3716
TAB2 8556 6836
TAB3 215 4794
TNIP2 -929 4907
TOLLIP 8936 8482
TRAF6 -4471 1582
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UBE2N 7813 4195
UBE2V1 8249 8108



The citric acid (TCA) cycle and respiratory electron transport

The citric acid (TCA) cycle and respiratory electron transport
metric value
setSize 172
pMANOVA 1.46e-15
p.adjustMANOVA 6.41e-14
s.dist 0.456
s.low.CRP 0.351
s.high.CRP 0.29
p.low.CRP 1.93e-15
p.high.CRP 4.96e-11




Top 20 genes
Gene low CRP high CRP
ETFDH 10012 10191
ME1 9527 10503
LDHA 10284 9549
BSG 9321 9898
SDHC 9342 9775
ETFA 9339 9616
NDUFB9 9167 9565
ATP5PB 9493 9015
ETFB 9144 9286
NDUFB3 9075 9321
SLC16A3 8534 9884
DLD 8939 9407
ATP5F1C 9580 8671
ATP5PD 9734 8460
SUCLA2 9774 8374
NDUFA4 8573 9057
NDUFB1 7433 10164
COX7A2L 9037 8303
NDUFAF1 8656 8639
SDHD 9801 7526

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACAD9 5414 4340
ACO2 4747 4737
ADHFE1 -549 -2485
ATP5F1A 9557 6994
ATP5F1B 8684 6919
ATP5F1C 9580 8671
ATP5F1D 474 359
ATP5F1E 6027 6878
ATP5MC1 5471 -6148
ATP5MC2 1987 2992
ATP5MC3 7250 7383
ATP5ME -322 5177
ATP5MF 7383 8461
ATP5MG 8134 7589
ATP5PB 9493 9015
ATP5PD 9734 8460
ATP5PF 7570 8666
ATP5PO 9184 6042
BSG 9321 9898
COQ10A -8775 -8783
COQ10B 6069 3637
COX11 -5218 -9151
COX14 3006 -1658
COX16 8909 998
COX18 4592 -2426
COX19 1920 -3944
COX20 3257 -2193
COX4I1 5132 3979
COX5A 7687 7980
COX5B 6345 7810
COX6A1 3840 6505
COX6B1 6445 7034
COX6C 6357 4173
COX7A2L 9037 8303
COX7B 6183 6675
COX7C 910 974
COX8A 5588 7834
CS 7611 6549
CYC1 -437 4720
CYCS 7831 2324
D2HGDH -1735 -4104
DLAT 1761 3102
DLD 8939 9407
DLST -9444 -2022
DMAC2L -3270 -3208
ECSIT 5443 4562
ETFA 9339 9616
ETFB 9144 9286
ETFDH 10012 10191
FAHD1 1616 -1492
FH 5441 6335
GLO1 3425 4233
GSTZ1 7362 8245
HAGH 5635 2617
IDH2 -5977 554
IDH3A 5493 -1148
IDH3B 2500 -1159
IDH3G 2782 3946
L2HGDH -852 -7238
LDHA 10284 9549
LDHAL6A -995 614
LDHB 2425 -9752
LRPPRC -21 -7930
MDH2 5674 6208
ME1 9527 10503
ME2 9745 7547
ME3 -6761 -9043
MPC1 8067 1435
MPC2 6843 4288
MT-ATP6 -5000 3338
MT-ATP8 -8176 7306
MT-CO1 2995 5163
MT-CO2 2723 3643
MT-CO3 307 4978
MT-CYB -2505 365
MT-ND1 -3359 -920
MT-ND2 -6325 -4137
MT-ND3 886 1784
MT-ND4 641 3660
MT-ND5 -2601 2772
MT-ND6 6472 6305
NDUFA1 5265 7768
NDUFA10 -5642 -1013
NDUFA11 4155 -1362
NDUFA12 6496 3034
NDUFA13 2094 5390
NDUFA2 3139 5257
NDUFA3 1012 2616
NDUFA4 8573 9057
NDUFA5 4399 -1289
NDUFA6 3765 6106
NDUFA7 7692 7856
NDUFA8 8951 4747
NDUFA9 954 -153
NDUFAB1 9435 5334
NDUFAF1 8656 8639
NDUFAF2 4249 5603
NDUFAF3 4509 6763
NDUFAF4 -2041 -9027
NDUFAF5 -4385 -3905
NDUFAF6 2220 2420
NDUFAF7 -2530 5726
NDUFB1 7433 10164
NDUFB10 6206 6495
NDUFB11 -293 -282
NDUFB2 -3647 -4166
NDUFB3 9075 9321
NDUFB4 6520 6110
NDUFB5 8646 6075
NDUFB6 5249 4452
NDUFB7 2963 1058
NDUFB8 752 3261
NDUFB9 9167 9565
NDUFC1 7046 8373
NDUFC2 7348 9008
NDUFS1 5479 9340
NDUFS2 4737 7929
NDUFS3 1276 2496
NDUFS4 8342 4293
NDUFS5 4941 7336
NDUFS6 4032 6868
NDUFS7 3115 2433
NDUFS8 3125 -1053
NDUFV1 -7714 -8421
NDUFV2 9236 7085
NDUFV3 8152 7579
NNT -2982 8223
NUBPL -6298 -8977
OGDH -2787 5155
PDHA1 1603 3183
PDHB 8732 5499
PDHX 9405 5798
PDK1 7585 1755
PDK2 -8421 -6309
PDK3 -3793 2930
PDK4 6383 8816
PDP1 -902 -7047
PDP2 -8253 -10235
PDPR -9292 -2942
PM20D1 -7373 -9620
PPARD -2980 -6109
RXRA 6389 8760
SCO1 -560 -5166
SCO2 5178 -9665
SDHA -7420 -4414
SDHB 7368 9153
SDHC 9342 9775
SDHD 9801 7526
SLC16A1 5760 3184
SLC16A3 8534 9884
SLC16A8 -9216 6532
SLC25A14 -1042 -2588
SLC25A27 3773 -6502
SUCLA2 9774 8374
SUCLG1 7304 5981
SUCLG2 3705 -4033
SURF1 5404 1530
TACO1 4959 5943
TIMMDC1 8385 8473
TMEM126B -221 -3886
TRAP1 -4626 -9571
UCP2 -3241 4728
UCP3 -6187 -7539
UQCR10 3747 6293
UQCR11 8377 8061
UQCRB 6557 5036
UQCRC1 8264 8723
UQCRC2 9566 6489
UQCRFS1 7740 7015
UQCRH 8075 8773
UQCRQ 4092 3891
VDAC1 7258 5858



Response to elevated platelet cytosolic Ca2+

Response to elevated platelet cytosolic Ca2+
metric value
setSize 108
pMANOVA 1.77e-15
p.adjustMANOVA 7.55e-14
s.dist 0.569
s.low.CRP 0.353
s.high.CRP 0.446
p.low.CRP 2.17e-10
p.high.CRP 1.17e-15




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
CD36 10363 10493
CYB5R1 10052 10467
LHFPL2 9993 10508
SERPINA1 10186 10295
QSOX1 9888 10475
APLP2 9754 10588
CD63 9814 10489
ALDOA 10140 10121
APP 10085 9961
STXBP2 9851 10088
FERMT3 9665 10217
GAS6 9599 9997
ANXA5 10047 9393
CLU 8797 10607
ACTN1 9802 9301
SRGN 9966 9137
CLEC3B 8957 10039
HGF 8952 9949
LAMP2 9626 9234

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201 6324
A2M -7493 -9192
ABCC4 4731 8657
ACTN1 9802 9301
ACTN4 -6751 7995
ALB 5157 1598
ALDOA 10140 10121
ANXA5 10047 9393
APLP2 9754 10588
APOOL 6366 5539
APP 10085 9961
BRPF3 -9645 -6135
CALM1 -4337 1051
CALU 8618 9731
CAP1 9134 8626
CD109 6898 6560
CD36 10363 10493
CD63 9814 10489
CD9 7795 5893
CDC37L1 1694 -5736
CFD 911 -342
CFL1 9368 9341
CHID1 1491 3495
CLEC3B 8957 10039
CLU 8797 10607
CTSW -10450 -9076
CYB5R1 10052 10467
ECM1 8140 6368
EGF 8136 8196
ENDOD1 -3996 3892
F13A1 9500 8453
F5 10339 10599
F8 7904 8494
FAM3C -5488 -5977
FERMT3 9665 10217
FLNA -8851 2557
FN1 9912 6648
GAS6 9599 9997
GTPBP2 -3289 8058
HABP4 -4596 -10369
HGF 8952 9949
HSPA5 9415 6475
ITGA2B 8831 9692
ITGB3 7696 8680
ITIH3 -1661 -2817
ITIH4 -4505 -2214
LAMP2 9626 9234
LGALS3BP -278 -10598
LHFPL2 9993 10508
LY6G6F 6222 9342
MAGED2 -5635 1105
MANF 7239 1636
MMRN1 7311 8075
NHLRC2 -4230 -5211
OLA1 9281 7615
ORM1 9208 6694
ORM2 1731 -2088
PCYOX1L 2112 -3420
PDGFA 1176 5657
PDGFB -8368 -7863
PECAM1 7190 9387
PF4 3055 6229
PFN1 1471 6861
PHACTR2 -1263 7436
PLEK -3117 3467
PLG 299 -2400
PPBP 5440 6001
PPIA 285 1417
PRKCA 2691 1966
PRKCB -4906 9024
PROS1 8002 7705
PSAP 8066 8239
QSOX1 9888 10475
RAB27B -6595 4754
SCCPDH 8217 9056
SELENOP 1102 -7075
SELP 8480 9339
SERPINA1 10186 10295
SERPINE1 3011 7764
SERPINF2 -10171 140
SERPING1 533 -10700
SOD1 3597 -3501
SPARC 7330 7225
SRGN 9966 9137
STX4 -4764 2706
STXBP2 9851 10088
STXBP3 9718 8688
SYTL4 234 9384
TAGLN2 5738 6791
TEX264 -9385 -6429
TF 2007 3922
TGFB1 984 3574
TGFB2 -3931 -4176
TGFB3 -6195 -4793
THBS1 1255 9820
TIMP1 6709 10267
TLN1 5974 9916
TMSB4X 3917 6032
TMX3 4031 2865
TOR4A 8478 10155
TTN -3218 6253
TUBA4A -92 4474
VCL 913 8321
VEGFA 7943 7054
VEGFB -4813 -5745
VTI1B 9366 9447
VWF 3995 7559
WDR1 -627 8316



Platelet degranulation

Platelet degranulation
metric value
setSize 104
pMANOVA 5.72e-15
p.adjustMANOVA 2.36e-13
s.dist 0.572
s.low.CRP 0.363
s.high.CRP 0.442
p.low.CRP 1.51e-10
p.high.CRP 6.13e-15




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
CD36 10363 10493
CYB5R1 10052 10467
LHFPL2 9993 10508
SERPINA1 10186 10295
QSOX1 9888 10475
APLP2 9754 10588
CD63 9814 10489
ALDOA 10140 10121
APP 10085 9961
STXBP2 9851 10088
FERMT3 9665 10217
GAS6 9599 9997
ANXA5 10047 9393
CLU 8797 10607
ACTN1 9802 9301
SRGN 9966 9137
CLEC3B 8957 10039
HGF 8952 9949
LAMP2 9626 9234

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201 6324
A2M -7493 -9192
ABCC4 4731 8657
ACTN1 9802 9301
ACTN4 -6751 7995
ALB 5157 1598
ALDOA 10140 10121
ANXA5 10047 9393
APLP2 9754 10588
APOOL 6366 5539
APP 10085 9961
BRPF3 -9645 -6135
CALM1 -4337 1051
CALU 8618 9731
CAP1 9134 8626
CD109 6898 6560
CD36 10363 10493
CD63 9814 10489
CD9 7795 5893
CDC37L1 1694 -5736
CFD 911 -342
CFL1 9368 9341
CHID1 1491 3495
CLEC3B 8957 10039
CLU 8797 10607
CTSW -10450 -9076
CYB5R1 10052 10467
ECM1 8140 6368
EGF 8136 8196
ENDOD1 -3996 3892
F13A1 9500 8453
F5 10339 10599
F8 7904 8494
FAM3C -5488 -5977
FERMT3 9665 10217
FLNA -8851 2557
FN1 9912 6648
GAS6 9599 9997
GTPBP2 -3289 8058
HABP4 -4596 -10369
HGF 8952 9949
HSPA5 9415 6475
ITGA2B 8831 9692
ITGB3 7696 8680
ITIH3 -1661 -2817
ITIH4 -4505 -2214
LAMP2 9626 9234
LGALS3BP -278 -10598
LHFPL2 9993 10508
LY6G6F 6222 9342
MAGED2 -5635 1105
MANF 7239 1636
MMRN1 7311 8075
NHLRC2 -4230 -5211
OLA1 9281 7615
ORM1 9208 6694
ORM2 1731 -2088
PCYOX1L 2112 -3420
PDGFA 1176 5657
PDGFB -8368 -7863
PECAM1 7190 9387
PF4 3055 6229
PFN1 1471 6861
PHACTR2 -1263 7436
PLEK -3117 3467
PLG 299 -2400
PPBP 5440 6001
PPIA 285 1417
PROS1 8002 7705
PSAP 8066 8239
QSOX1 9888 10475
RAB27B -6595 4754
SCCPDH 8217 9056
SELENOP 1102 -7075
SELP 8480 9339
SERPINA1 10186 10295
SERPINE1 3011 7764
SERPINF2 -10171 140
SERPING1 533 -10700
SOD1 3597 -3501
SPARC 7330 7225
SRGN 9966 9137
STXBP2 9851 10088
SYTL4 234 9384
TAGLN2 5738 6791
TEX264 -9385 -6429
TF 2007 3922
TGFB1 984 3574
TGFB2 -3931 -4176
TGFB3 -6195 -4793
THBS1 1255 9820
TIMP1 6709 10267
TLN1 5974 9916
TMSB4X 3917 6032
TMX3 4031 2865
TOR4A 8478 10155
TTN -3218 6253
TUBA4A -92 4474
VCL 913 8321
VEGFA 7943 7054
VEGFB -4813 -5745
VTI1B 9366 9447
VWF 3995 7559
WDR1 -627 8316



Metabolism of lipids

Metabolism of lipids
metric value
setSize 619
pMANOVA 8.44e-15
p.adjustMANOVA 3.38e-13
s.dist 0.226
s.low.CRP 0.124
s.high.CRP 0.189
p.low.CRP 1.28e-07
p.high.CRP 9.92e-16




Top 20 genes
Gene low CRP high CRP
PLBD1 10356 10674
PPARG 10358 10670
CTSA 10310 10636
CD36 10363 10493
HADHB 10224 10621
PLA2G4A 10226 10618
CYP1B1 10171 10672
PLB1 10170 10628
HSD3B7 10138 10609
PLD1 10119 10572
PLIN3 10168 10515
GM2A 9951 10624
PRKACA 9995 10558
ACER3 10198 10258
LTA4H 10110 10291
FIG4 9790 10585
TSPO 10124 10235
PCTP 10228 10119
SGMS2 9770 10581
PTGR1 9739 10613

Click HERE to show all gene set members

All member genes
low CRP high CRP
AACS -6141 2931
ABCA1 4951 6830
ABCB4 -8019 -3110
ABCC1 -3572 1312
ABCC3 -4603 7268
ABCD1 5996 7409
ABHD3 8948 6671
ABHD4 -1813 7071
ABHD5 7194 8817
ACAA1 7355 9532
ACAA2 6098 7666
ACACA 829 7444
ACACB -9101 -7479
ACAD10 7338 5940
ACAD11 -6277 -7640
ACADL -1148 4496
ACADM 8574 3014
ACADS -621 6099
ACADVL 9301 9478
ACAT1 8823 4736
ACAT2 6310 -2016
ACBD4 4093 -3230
ACBD5 -3464 2751
ACBD6 -8804 -9501
ACBD7 1988 6303
ACER1 -5318 -7883
ACER2 -4435 1384
ACER3 10198 10258
ACLY -3480 8333
ACOT1 -7538 -6515
ACOT11 -4097 1879
ACOT13 9461 6798
ACOT2 -9931 -6571
ACOT4 -7082 -9355
ACOT7 -3916 -4645
ACOT8 5734 9612
ACOT9 6782 7802
ACOX1 9058 9176
ACOX2 9378 10638
ACOX3 -232 7566
ACOXL 6582 1899
ACP6 -3860 -7528
ACSBG1 -6230 -1152
ACSF2 -9944 -5903
ACSF3 -3777 2610
ACSL1 10178 9937
ACSL3 8662 9192
ACSL4 9875 9975
ACSL5 -6544 -5467
ACSL6 7022 -8092
ACSM3 -7607 -4969
ACSM6 -1965 7099
ACSS3 8605 9804
AGK -8892 -10246
AGPAT1 5231 9255
AGPAT2 9571 10463
AGPAT3 7444 4388
AGPAT4 -10656 -980
AGPAT5 -3592 -6740
AGPS 7127 7704
AHR 8112 9783
AHRR -891 1757
AKR1B1 -9090 -9817
AKR1B15 6446 2159
AKR1C1 5170 -820
AKR1C2 -4189 -4494
AKR1C3 -10816 -7648
ALAS1 9393 6864
ALB 5157 1598
ALDH3A2 6113 4015
ALDH3B1 9122 10008
ALOX12 6136 7443
ALOX12B -3969 -5752
ALOX15 -5374 -9427
ALOX15B 7208 9628
ALOX5 9735 9772
ALOX5AP 8526 7162
AMACR -9979 -2155
ANGPTL4 -7888 2021
APOA2 7224 7075
ARF1 9085 10196
ARF3 7124 9257
ARNT 6732 10010
ARNTL -10164 -1541
ARSA 6282 1069
ARSB 8290 9046
ARSD 7388 8269
ARSG -4 -7971
ARSJ -5813 -6407
ARSK -7489 -9464
ARV1 5131 5075
ASAH1 9394 10144
ASAH2 -6475 -6478
B3GALNT1 2892 8344
BDH1 -2447 -10075
BDH2 -896 -9968
BMX 7713 9372
CARM1 9302 10024
CAV1 1798 -1413
CBR1 6575 1365
CBR4 1848 4465
CCNC 8958 4374
CD36 10363 10493
CDIPT 4777 5211
CDK19 -268 9996
CDK8 -1289 2360
CDS1 4952 -2445
CDS2 4321 8637
CEPT1 7815 6484
CERK -8098 -2754
CERS2 9287 9555
CERS3 1516 -2225
CERS4 -7636 -2971
CERS5 -566 3745
CERS6 5284 5804
CERT1 8580 8411
CHD9 -7440 4616
CHKA 5361 8387
CHKB 682 -4483
CHPT1 8237 8809
CLOCK -6053 -3825
CPNE1 -7255 -6504
CPNE3 8631 6794
CPNE7 649 -7412
CPT1A 2948 6756
CPT1B 586 -4472
CPT2 5476 9156
CPTP -1778 -230
CRAT 7800 9800
CREBBP -9358 1958
CRLS1 10232 9577
CROT -9760 -10594
CSNK1G2 -7707 1858
CSNK2A1 1926 9964
CSNK2A2 136 9661
CSNK2B 4787 4600
CTSA 10310 10636
CUBN 3637 -8340
CYP1A2 -744 4997
CYP1B1 10171 10672
CYP27A1 5784 2844
CYP2C9 4176 7785
CYP2D6 -2583 -7028
CYP2E1 -671 -9982
CYP2R1 -9251 -308
CYP2U1 -10657 -10266
CYP46A1 3304 1787
CYP4F22 -10929 -10406
CYP4F3 6079 4596
CYP4F8 -4489 1534
CYP51A1 8344 8766
CYP7B1 -6090 -4311
DBI 3542 9499
DDHD1 -7999 -9193
DDHD2 -7240 -10059
DECR1 8621 7403
DECR2 -3230 880
DEGS1 8935 6383
DEGS2 -10655 -4970
DGAT1 879 2318
DGAT2 10122 9982
DHCR24 -2264 6589
DHCR7 5124 8197
DHRS7B 8891 9075
DPEP2 -7575 -7040
DPEP3 -509 -9183
EBP -9864 -9955
ECHS1 4495 -1054
ECI1 818 697
ECI2 -7278 -9201
EHHADH 5018 8755
ELOVL1 5593 8179
ELOVL3 10220 9260
ELOVL4 1844 -9329
ELOVL5 7670 5549
ELOVL6 -10674 -6390
ELOVL7 6773 7878
ENPP6 -305 2782
EP300 -2315 7280
EPHX2 -1499 -10373
ESRRA 2508 6978
ESYT1 -10020 -9944
ESYT2 -8724 -8572
ETNK1 3981 424
ETNK2 -9574 -6401
FA2H 3440 -1414
FAAH 1400 -7239
FAAH2 7471 -6536
FABP2 -4153 4235
FABP3 -9380 -7048
FABP5 6772 7102
FADS1 6968 9327
FADS2 1344 7263
FAM120B -5237 1265
FAR1 10144 9605
FAR2 10203 9236
FASN -4442 -2375
FDFT1 6738 9135
FDPS 2989 7591
FDX1 6054 -653
FDX2 -1694 -7020
FDXR 9148 3744
FHL2 -1874 5631
FIG4 9790 10585
FITM1 -6627 -4138
FITM2 -4015 -3895
G0S2 6743 6235
GALC 7969 10450
GBA 9467 9882
GBA2 -6594 5916
GDE1 9177 8852
GDPD1 -5380 -1696
GDPD3 7486 3523
GDPD5 -7604 -10039
GGPS1 7824 1722
GGT1 10054 10098
GGT5 -401 3250
GK 10064 9859
GLA 7742 9617
GLB1 9395 10125
GLB1L -2931 4158
GLIPR1 10116 7714
GLTP 7173 10376
GM2A 9951 10624
GNPAT 7150 9346
GPAM -8942 -5191
GPAT2 -4284 -4175
GPAT3 9824 7397
GPAT4 -7112 6041
GPCPD1 9563 9885
GPD1 -4549 -370
GPD1L -4573 -6926
GPD2 7686 9569
GPS2 -3941 -2386
GPX1 9841 9615
GPX2 -1463 -2988
GPX4 5120 3939
GRHL1 -1957 -1386
GSTM4 -1334 2605
HACD1 6094 7360
HACD2 -793 4277
HACD3 -6965 -8969
HACD4 6423 7503
HACL1 -2709 -9733
HADH -8309 -8511
HADHA 9533 10380
HADHB 10224 10621
HDAC3 7060 7743
HELZ2 -10149 -8681
HEXA 1499 2409
HEXB 9686 9967
HILPDA -57 -2458
HMGCL 5616 8110
HMGCR 8233 8629
HMGCS1 3863 2380
HPGD 1547 7850
HSD11B2 7493 6610
HSD17B1 -1265 -2218
HSD17B11 8970 8322
HSD17B12 7661 7516
HSD17B13 3610 8121
HSD17B2 699 4654
HSD17B4 9650 10264
HSD17B7 -845 -7421
HSD17B8 -3129 -7260
HSD3B7 10138 10609
HTD2 1939 -1885
IDI1 9201 7719
INPP4A -10669 -6036
INPP4B 2393 -10234
INPP5D -10748 -563
INPP5E 16 -8060
INPP5F -4623 1416
INPP5K -1032 -4246
INPPL1 9545 10037
INSIG1 -10677 -5462
INSIG2 8472 8040
KDSR 7726 -7835
KPNB1 67 557
LBR 9305 8261
LCLAT1 2588 2682
LGMN -2173 -1771
LIPE -7484 -8741
LIPH -6833 5108
LPCAT1 -10615 -1283
LPCAT2 10279 8980
LPCAT3 9182 9470
LPCAT4 -3163 -6636
LPGAT1 9234 9471
LPIN1 -6615 -8764
LPIN2 -3111 -8979
LPIN3 746 -4770
LRP2 -392 6762
LSS -9415 -8363
LTA4H 10110 10291
LTC4S -665 -3436
MAPKAPK2 -10648 4888
MBOAT1 6004 5067
MBOAT2 9664 7323
MBOAT7 9673 8771
MBTPS1 -1835 5184
MBTPS2 1231 5741
MCAT 4954 4803
MCEE 4174 -38
ME1 9527 10503
MECR 2575 -4057
MED1 -6238 727
MED10 -828 -7417
MED11 1992 -2444
MED12 -8380 1471
MED13 -1483 4991
MED13L 6 7722
MED14 -2412 3032
MED15 -8353 -9757
MED16 7359 4691
MED17 7200 1962
MED18 -193 6966
MED19 5075 4066
MED20 6919 9143
MED21 122 -1891
MED22 -5377 1941
MED23 -6461 -3313
MED24 -9165 -2277
MED25 4306 7693
MED26 -4575 7407
MED27 -5519 -3826
MED28 1419 1141
MED29 -7150 -5307
MED30 -3213 -6485
MED31 8682 -414
MED4 8051 5518
MED6 7820 344
MED7 5411 5193
MED8 8376 8117
MED9 -7351 -4924
MFSD2A 3864 -6625
MGLL 5785 8910
MID1IP1 987 -4253
MIGA1 -1607 -6785
MIGA2 -6495 -6802
MLYCD -8511 -8106
MMAA -4030 -6839
MMUT 8024 6667
MOGAT3 -2321 2379
MORC2 -1368 -7797
MSMO1 6953 4919
MTF1 10000 9766
MTM1 9469 6434
MTMR1 -7482 -1234
MTMR10 8020 8731
MTMR12 -6532 2399
MTMR14 8458 9446
MTMR2 -4534 489
MTMR3 8633 10212
MTMR4 -6891 4594
MTMR6 9243 8582
MTMR7 3296 791
MTMR8 -9426 -6035
MTMR9 671 5127
MVD -7748 -625
MVK -10315 -4217
NCOA1 -3324 5089
NCOA2 -7260 1011
NCOA3 -2432 5828
NCOA6 -5126 8092
NCOR1 -1531 9348
NCOR2 -2998 10117
NDUFAB1 9435 5334
NEU1 9609 10026
NEU3 -5831 -3117
NFYA -2090 1602
NFYB -88 -9577
NFYC 7025 8726
NPAS2 2505 -49
NR1D1 1986 -8359
NR1H2 4953 7742
NR1H3 -3942 -2012
NRF1 -9882 -5101
NSDHL 5988 5904
NUDT19 3945 8338
NUDT7 621 -161
OCRL 6438 9145
ORMDL1 -3006 926
ORMDL2 7325 7321
ORMDL3 -10039 -8440
OSBP -4175 1633
OSBPL10 -4552 -204
OSBPL1A -7050 -8293
OSBPL2 -10034 3650
OSBPL3 -10063 -10304
OSBPL5 -10926 -10167
OSBPL6 5552 -1949
OSBPL7 -9130 -9284
OSBPL8 8630 6591
OSBPL9 6745 6806
OXCT1 -6197 -9522
OXCT2 145 -6381
PCCA -5364 -5495
PCCB -8367 -5614
PCTP 10228 10119
PCYT1A 5243 7254
PCYT1B 2035 9155
PCYT2 -9500 -8878
PECR 8882 9503
PEMT 7879 -1580
PEX11A -9705 958
PGS1 8806 9233
PHOSPHO1 -6085 -4415
PHYH 5084 -674
PI4K2A -10071 170
PI4K2B -1306 -9965
PI4KA -7281 -1853
PI4KB -5384 -3857
PIAS4 -2221 7565
PIK3C2A 99 -876
PIK3C2B -10282 -10321
PIK3C2G -1717 -828
PIK3C3 4588 3248
PIK3CA 5168 6821
PIK3CB 9880 9707
PIK3CD -932 3422
PIK3CG -9133 3842
PIK3R1 -7314 -9108
PIK3R2 2369 6022
PIK3R3 -10971 -7175
PIK3R4 -624 -83
PIK3R5 -10408 -5867
PIK3R6 6288 8699
PIKFYVE -122 5199
PIP4K2A -8550 3142
PIP4K2B -7834 -2440
PIP4K2C -10333 -5556
PIP5K1A 7643 7381
PIP5K1B 3569 6574
PIP5K1C -4414 4334
PISD 8987 10281
PITPNB 3137 -1255
PITPNM1 -5993 6953
PITPNM2 -9116 2634
PITPNM3 -1512 2279
PLA2G10 -632 -4935
PLA2G12A 4168 4597
PLA2G15 7645 10382
PLA2G2D -143 2911
PLA2G4A 10226 10618
PLA2G4B 1435 -6178
PLA2G4C -7987 17
PLA2G4D -5097 4824
PLA2G6 -10438 -10350
PLA2R1 3499 7129
PLAAT1 2747 3326
PLAAT2 5182 -5374
PLAAT3 -9871 -7641
PLAAT4 -10146 -10689
PLB1 10170 10628
PLBD1 10356 10674
PLD1 10119 10572
PLD2 6138 9091
PLD3 8046 6488
PLD4 -11002 -10493
PLD6 5755 -5697
PLEKHA1 -10527 -10395
PLEKHA2 -7524 1744
PLEKHA3 -3081 565
PLEKHA4 -4482 589
PLEKHA5 -6000 -4521
PLEKHA6 -2744 -4606
PLEKHA8 -2105 -1934
PLIN1 -6520 3635
PLIN2 6236 10259
PLIN3 10168 10515
PLPP1 7609 -7962
PLPP2 5848 3305
PLPP3 3344 9714
PLPP6 -8764 -5841
PMVK 5102 4922
PNPLA2 9549 9963
PNPLA4 2831 -44
PNPLA6 -3444 8208
PNPLA7 -3337 -6703
PNPLA8 9191 8945
POMC 2426 -2728
PON2 -3370 879
PPARA -7992 2961
PPARD -2980 -6109
PPARG 10358 10670
PPARGC1A 5105 6389
PPARGC1B -2932 -2066
PPM1L -9905 4684
PPP1CA 1299 5236
PPP1CB 8424 7913
PPP1CC 9534 8032
PPT1 10321 9873
PPT2 -9994 -9068
PRKAB2 -6078 -3690
PRKACA 9995 10558
PRKACB -8479 -10448
PRKAG2 7267 1382
PRKD2 -8779 -7038
PRKD3 2093 6620
PRXL2B 835 -8833
PSAP 8066 8239
PTDSS1 9364 6940
PTDSS2 5420 3726
PTEN 8668 9329
PTGDS -10042 -5523
PTGES -7502 2537
PTGES2 -4699 -4573
PTGES3 9517 4303
PTGR1 9739 10613
PTGR2 5321 6976
PTGS1 8122 8323
PTGS2 8500 5863
PTPMT1 6451 1642
PTPN13 -7614 -7223
RAB14 8765 8436
RAB4A 8673 6735
RAB5A 9230 7808
RAN 4957 -2873
RGL1 9370 9936
RORA -10427 -10611
RUFY1 2628 6507
RXRA 6389 8760
RXRB -2481 479
SACM1L -6759 -5024
SAMD8 7895 8227
SAR1B 9412 8914
SBF1 -10005 -8548
SBF2 9786 10402
SC5D 5204 -227
SCAP -7316 -7643
SCD 4702 3606
SCD5 -10439 -2366
SCP2 7718 6645
SEC23A 8250 8136
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SELENOI -2536 -8997
SGMS1 8975 10145
SGMS2 9770 10581
SGPL1 -7740 7182
SGPP1 -10860 -8813
SGPP2 -2498 -6353
SIN3A -8565 -8326
SIN3B -5683 -6222
SLC10A1 -547 -1978
SLC22A5 8103 9235
SLC25A1 4097 6169
SLC25A17 2344 -4434
SLC25A20 -3354 6571
SLC27A1 8348 8149
SLC27A2 8033 -6002
SLC27A3 -2658 -2290
SLC27A5 -2143 568
SLC44A1 8910 9654
SLC44A2 -3421 2167
SLC44A5 4109 -573
SMARCD3 10015 8573
SMPD1 -9521 2160
SMPD2 -4755 5874
SMPD3 -10029 -9933
SMPD4 -9407 -7697
SP1 6728 9578
SPHK1 8695 8421
SPHK2 -6162 4445
SPNS2 6156 4825
SPTLC1 9600 10012
SPTLC2 8663 10151
SPTLC3 6204 2354
SPTSSA 8052 -50
SPTSSB -10212 -3415
SQLE 2769 8138
SRD5A1 9060 8926
SRD5A3 7881 1403
SREBF1 8706 1961
SREBF2 4892 8248
STAR -1085 -1594
STARD10 6043 -2723
STARD3 -6350 4096
STARD3NL 7975 8944
STARD4 -2521 -789
STARD5 -9504 985
STARD7 4649 6076
STS 176 5094
SUMF1 9836 10078
SUMF2 -10639 -7655
SUMO2 8206 6024
SYNJ1 1280 7746
SYNJ2 -6719 -7296
TAZ 4315 4951
TBL1X 6931 7717
TBL1XR1 5299 5430
TBXAS1 8240 10114
TECR -4076 -7329
TECRL -5434 1478
TGS1 410 -2742
THEM4 -1580 -10466
THEM5 -1662 -9783
THRAP3 -4430 3845
TIAM2 -9556 -9322
TM7SF2 -3634 -5918
TMEM86B 4861 828
TNFAIP8 4030 1508
TNFAIP8L1 -9678 -7149
TNFAIP8L2 8056 2927
TNFRSF21 -10898 -4962
TRIB3 -7114 -4878
TSPO 10124 10235
TSPOAP1 -10588 -9052
TXNRD1 8785 8833
UBE2I -1027 5239
UGCG 5761 5972
UGT8 -6633 440
VAC14 -4428 4493
VAPA 9859 9626
VAPB 5006 4743
VDR 5697 10052



rRNA processing

rRNA processing
metric value
setSize 218
pMANOVA 9.52e-15
p.adjustMANOVA 3.71e-13
s.dist 0.242
s.low.CRP 0.0186
s.high.CRP -0.241
p.low.CRP 0.636
p.high.CRP 7.96e-10




Top 20 genes
Gene low CRP high CRP
RPP40 7453 -8690
GNL3 6083 -7025
RPP38 5051 -7716
WDR75 4353 -8698
NOP58 4347 -8474
TSR1 4712 -7123
MPHOSPH10 5952 -4333
EMG1 4466 -5473
TRMT10C 7114 -3353
RPS3A 5865 -3619
UTP15 2657 -7360
EXOSC9 2761 -7072
RPP30 5972 -3194
RPS26 3527 -5041
NOL11 1925 -8448
DIMT1 2279 -6842
RPL18 3381 -4456
EXOSC5 1739 -8095
DDX47 1777 -7672
RPS3 2486 -5123

Click HERE to show all gene set members

All member genes
low CRP high CRP
BMS1 -5936 -8197
BOP1 -3795 -5762
BYSL -1005 -2393
C1D 6736 4014
CSNK1D -8768 1189
CSNK1E -9314 -5872
DCAF13 327 6103
DDX21 9035 4115
DDX47 1777 -7672
DDX49 3833 4376
DDX52 8089 4089
DHX37 -7195 -4839
DIMT1 2279 -6842
DIS3 1689 -830
DKC1 -4589 -10307
EBNA1BP2 5515 -1375
ELAC2 -9406 -5824
EMG1 4466 -5473
ERI1 5656 5643
EXOSC1 2885 304
EXOSC10 -6650 -5828
EXOSC2 -3961 -8955
EXOSC3 1418 2162
EXOSC4 5868 7957
EXOSC5 1739 -8095
EXOSC6 -9351 -7944
EXOSC7 -6315 -5278
EXOSC8 -3547 -9913
EXOSC9 2761 -7072
FAU -1127 -1637
FBL -6170 -7357
FCF1 7340 6857
FTSJ3 -4598 507
GAR1 1898 -2266
GNL3 6083 -7025
HEATR1 -5578 -8123
HSD17B10 6214 6724
IMP3 -7393 -8684
IMP4 -7848 -9701
ISG20L2 732 5116
KRR1 375 -5095
LAS1L -9410 -9422
LTV1 7672 3314
MPHOSPH10 5952 -4333
MPHOSPH6 5285 7932
MRM1 -6603 -8786
MRM2 6131 2818
MRM3 -7121 -6350
MT-ATP6 -5000 3338
MT-ATP8 -8176 7306
MT-CO1 2995 5163
MT-CO2 2723 3643
MT-CO3 307 4978
MT-CYB -2505 365
MT-ND1 -3359 -920
MT-ND2 -6325 -4137
MT-ND3 886 1784
MT-ND4 641 3660
MT-ND4L -5984 3290
MT-ND5 -2601 2772
MT-RNR1 -4660 -192
MT-RNR2 -4826 4275
MT-TF -7110 -3561
MT-TL1 -9034 -5535
MT-TL2 -9109 -5765
MT-TM -9517 -3774
MT-TV -8649 -6121
MTERF4 -8800 -9005
MTREX 4323 3278
NAT10 -8029 -9599
NCL -4547 -7597
NHP2 4484 -2384
NIP7 2396 -3614
NOB1 -6895 -7557
NOC4L -6324 -2308
NOL11 1925 -8448
NOL12 6226 5817
NOL6 -7959 -8898
NOL9 -6074 -8704
NOP10 8570 9831
NOP14 -6422 -8870
NOP2 -4106 -6672
NOP56 -5022 -9989
NOP58 4347 -8474
NSUN4 -5034 906
PDCD11 -10108 -7686
PELP1 -2643 -9040
PES1 4862 -993
PNO1 6437 -1058
PRORP 4765 6138
PWP2 2407 4941
RBM28 -10189 -7366
RCL1 7236 2023
RIOK1 5183 3907
RIOK2 9357 84
RIOK3 9413 9229
RPL10 631 -5696
RPL10A 1976 -6292
RPL11 1839 -3327
RPL12 2014 -5298
RPL13 2796 -3228
RPL13A -1728 -6706
RPL14 -1317 -5766
RPL15 5748 532
RPL17 143 -3476
RPL18 3381 -4456
RPL18A -1706 -4694
RPL19 -787 -4539
RPL21 276 -3918
RPL22 4761 -1687
RPL22L1 7231 -349
RPL23 3153 -1612
RPL23A -903 -7885
RPL24 1656 -1751
RPL26 842 -3483
RPL26L1 8258 7992
RPL27 1376 -417
RPL27A -1685 -3049
RPL28 2709 -1855
RPL29 1515 -3475
RPL3 -3958 -7454
RPL30 -2576 -5578
RPL31 -429 -3242
RPL32 219 -4702
RPL34 -1732 -6642
RPL35 -9119 -4134
RPL35A -112 -2513
RPL36 -4022 -4235
RPL36A 1606 -4363
RPL36AL 5944 -2052
RPL37 -6271 -3029
RPL37A -2362 -447
RPL38 -4515 -3500
RPL39 2137 350
RPL39L -7572 -3974
RPL4 4738 -2403
RPL41 -1299 -3511
RPL5 4105 -2796
RPL6 4935 -1237
RPL7 5143 -1272
RPL7A 1809 -1927
RPL8 1265 -1924
RPL9 700 -4879
RPLP0 6333 -1009
RPLP1 -1197 916
RPLP2 -4847 -5802
RPP14 6153 3856
RPP21 -2599 -4355
RPP25 -6016 -6916
RPP30 5972 -3194
RPP38 5051 -7716
RPP40 7453 -8690
RPS10 -489 -4974
RPS11 -2316 -5641
RPS12 -4797 -7620
RPS13 5276 -1635
RPS14 -4624 -5393
RPS15 -1754 -3299
RPS15A 1269 -4048
RPS16 -2078 -6063
RPS17 -5045 -3169
RPS18 -7322 -6605
RPS19 -2989 -7057
RPS2 1634 -3308
RPS20 -2911 -6018
RPS21 -1933 -3896
RPS23 772 -4150
RPS24 6586 1001
RPS25 2600 -3817
RPS26 3527 -5041
RPS27 -7168 -6878
RPS27A -1868 -5386
RPS27L 7604 4230
RPS28 -2921 -3626
RPS29 -6817 -4617
RPS3 2486 -5123
RPS3A 5865 -3619
RPS4X -677 -7632
RPS4Y1 3815 574
RPS5 -1017 -5500
RPS6 2176 -3737
RPS7 1946 -2271
RPS8 3760 -769
RPS9 7673 4928
RPSA -3597 -5016
RRP1 1558 -5262
RRP36 -39 3862
RRP7A -4975 -3024
RRP9 72 -8148
SENP3 1324 5191
SNORD3A -9792 1193
SNU13 -139 -5644
TBL3 -4163 -4984
TEX10 -728 -6521
TFB1M -7154 -8810
THUMPD1 48 -9681
TRMT10C 7114 -3353
TRMT112 3035 510
TSR1 4712 -7123
TSR3 -1220 3240
UBA52 2067 260
UTP11 8322 6927
UTP14A 2019 2472
UTP14C -713 1477
UTP15 2657 -7360
UTP18 6514 7406
UTP20 -1589 -7369
UTP3 2595 699
UTP4 -736 -9058
UTP6 6320 367
WDR12 7691 8132
WDR18 3545 -3386
WDR3 -1131 -931
WDR36 2502 -1850
WDR43 2464 -3068
WDR46 -6771 -6887
WDR75 4353 -8698
XRN2 10201 10472



Antigen processing-Cross presentation

Antigen processing-Cross presentation
metric value
setSize 97
pMANOVA 1.34e-14
p.adjustMANOVA 5.09e-13
s.dist 0.581
s.low.CRP 0.457
s.high.CRP 0.36
p.low.CRP 7.43e-15
p.high.CRP 9.1e-10




Top 20 genes
Gene low CRP high CRP
CD36 10363 10493
FCGR1A 10365 10249
NCF2 10167 10265
CD14 10063 10306
NCF4 10090 10097
CYBB 10294 9839
FCGR1B 10361 9771
TLR2 10239 9881
TLR4 9286 10255
TLR1 10059 9241
LY96 9677 9581
PSMD6 9864 9375
CHUK 9608 9191
TLR6 9187 9277
CTSS 10120 8325
SNAP23 9581 8746
PSMB7 9346 8950
PSMA1 9165 8953
VAMP3 9466 8623
PSME3 9544 8452

Click HERE to show all gene set members

All member genes
low CRP high CRP
B2M 58 -7420
BTK 5823 9633
CALR 8310 6954
CD14 10063 10306
CD36 10363 10493
CHUK 9608 9191
CTSL -5492 6157
CTSS 10120 8325
CTSV 3692 -1862
CYBA 5409 8122
CYBB 10294 9839
FCGR1A 10365 10249
FCGR1B 10361 9771
HLA-A -3294 -7605
HLA-B 5549 -2345
HLA-C 1664 -2812
HLA-E -9947 -7245
HLA-F -9975 -10619
HLA-G -5725 -913
HLA-H -8262 -1093
IKBKB -6356 -1160
IKBKG -595 7203
ITGAV 4141 7107
ITGB5 4409 7405
LNPEP -9075 -5744
LY96 9677 9581
MRC1 -2922 4812
MRC2 1251 -3015
MYD88 8926 8524
NCF1 7986 3322
NCF2 10167 10265
NCF4 10090 10097
PDIA3 7841 5995
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
RPS27A -1868 -5386
SEC22B 9017 4952
SEC61A1 8546 7506
SEC61A2 -8294 -8164
SEC61B 9260 8673
SEC61G 8791 5259
SEM1 5210 6938
SNAP23 9581 8746
STX4 -4764 2706
TAP1 -3068 -10710
TAP2 -7592 -10537
TAPBP -391 911
TIRAP -8 6185
TLR1 10059 9241
TLR2 10239 9881
TLR4 9286 10255
TLR6 9187 9277
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
VAMP3 9466 8623
VAMP8 7797 7239



FCERI mediated Ca+2 mobilization

FCERI mediated Ca+2 mobilization
metric value
setSize 88
pMANOVA 1.9e-14
p.adjustMANOVA 6.96e-13
s.dist 0.36
s.low.CRP 0.0586
s.high.CRP -0.355
p.low.CRP 0.342
p.high.CRP 8.57e-09




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
AHCYL1 4949 8470
BTK 5823 9633
CALM1 -4337 1051
GRAP2 -2556 4557
GRB2 9960 10389
IGHE -4940 -4979
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
ITK -5396 -10354
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
LAT -8158 -10401
LCP2 5338 -3004
LYN 8483 8583
NFATC1 -9820 -3625
NFATC2 -10949 -10428
NFATC3 -10649 -10621
PLCG1 -5836 -10187
PLCG2 -6227 6708
PPP3CA 3489 7766
PPP3CB 9261 8237
PPP3R1 8749 9050
SHC1 3101 5292
SOS1 2394 -4661
SYK 9750 10350
TEC 6790 9842
TXK -9126 -9892
VAV1 6299 7892
VAV2 -9043 2054
VAV3 -7486 7780



Metabolism of RNA

Metabolism of RNA
metric value
setSize 686
pMANOVA 1.94e-14
p.adjustMANOVA 6.96e-13
s.dist 0.126
s.low.CRP 0.122
s.high.CRP -0.0309
p.low.CRP 5.16e-08
p.high.CRP 0.167




Top 20 genes
Gene low CRP high CRP
RPP40 7453 -8690
PUS7 6651 -7722
METTL1 6624 -7563
GNL3 6083 -7025
FAM98B 5721 -7231
SEH1L 8372 -4799
RPP38 5051 -7716
WDR75 4353 -8698
GCFC2 3958 -9381
PSME2 3614 -10267
NOP58 4347 -8474
NUP54 6985 -5266
NCBP2 6179 -5809
TSR1 4712 -7123
PSMA5 6009 -5256
PSMA3 8811 -3545
PSMB8 5148 -5793
MPHOSPH10 5952 -4333
EMG1 4466 -5473
TYW3 4045 -6014

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1CF 2704 867
AAAS -4220 -2848
ACTB 10142 9915
ADAR -6808 -4937
ADARB1 -3397 -2557
ADAT1 -9856 -4016
ADAT2 3040 -7822
ADAT3 -3577 3755
AKT1 -5096 2421
ALKBH8 -5909 -9642
ALYREF 7954 5654
ANP32A 9146 9208
APOBEC2 1290 -2098
APOBEC3A 6355 -367
APOBEC3B -2298 -2614
APOBEC3C -7215 -4591
APOBEC3H -867 -8407
AQR 4874 7105
BCAS2 4184 -3749
BMS1 -5936 -8197
BOP1 -3795 -5762
BUD31 8100 8051
BYSL -1005 -2393
C1D 6736 4014
C2orf49 4875 -2612
CASC3 -7453 3520
CCAR1 3098 3599
CCNH 1319 6144
CD2BP2 -8311 2790
CD44 9109 9660
CDC40 8672 8445
CDC5L 6493 7748
CDK7 6763 7641
CDKAL1 -4924 -3267
CHERP -6687 -3426
CHTOP -3694 3140
CLNS1A 8799 191
CLP1 8328 7511
CNOT1 -7986 477
CNOT10 3575 2853
CNOT11 5590 6262
CNOT2 5389 4630
CNOT3 3763 4088
CNOT4 -558 -333
CNOT6 10 7564
CNOT6L -8999 -10119
CNOT7 6799 -1888
CNOT8 9128 8340
CPSF1 -7313 -896
CPSF2 9473 9917
CPSF3 8186 8882
CPSF4 -8827 -4896
CPSF7 3376 4899
CRNKL1 6253 4238
CSNK1D -8768 1189
CSNK1E -9314 -5872
CSTF1 -499 -2973
CSTF2 -2002 -1481
CSTF2T -3602 -3213
CSTF3 4736 7070
CTNNBL1 -2170 6567
CTU1 -1869 3239
CTU2 -2135 -7403
CWC15 3748 1904
CWC22 6622 2673
CWC25 4972 1380
CWC27 7649 5882
DCAF13 327 6103
DCP1A -2153 -3199
DCP1B -9145 -7943
DCP2 7049 7228
DCPS 1816 1322
DDX1 5831 2904
DDX20 -4602 -7115
DDX21 9035 4115
DDX23 -6330 3203
DDX39A -1571 -9213
DDX39B -4193 -1323
DDX42 -4110 3639
DDX46 2952 5361
DDX47 1777 -7672
DDX49 3833 4376
DDX5 -9939 -6160
DDX52 8089 4089
DDX6 -3742 -116
DHX15 4023 943
DHX16 -7099 -5506
DHX37 -7195 -4839
DHX38 -9128 555
DHX9 2898 2519
DIMT1 2279 -6842
DIS3 1689 -830
DKC1 -4589 -10307
DNAJC8 4754 4539
DUS2 454 3711
EBNA1BP2 5515 -1375
EDC3 -1956 6025
EDC4 -6752 -5629
EFTUD2 9737 9573
EIF4A1 9825 8652
EIF4A2 -4531 -9693
EIF4A3 8711 7414
EIF4B 2213 1367
EIF4E 8016 7576
EIF4G1 5724 10120
ELAC2 -9406 -5824
ELAVL1 1210 4619
EMG1 4466 -5473
ENPP2 4361 4777
EPRS1 3916 1660
ERCC2 -974 6111
ERCC3 -8528 -1350
ERI1 5656 5643
ETF1 9199 8093
EXOSC1 2885 304
EXOSC10 -6650 -5828
EXOSC2 -3961 -8955
EXOSC3 1418 2162
EXOSC4 5868 7957
EXOSC5 1739 -8095
EXOSC6 -9351 -7944
EXOSC7 -6315 -5278
EXOSC8 -3547 -9913
EXOSC9 2761 -7072
FAM98B 5721 -7231
FAU -1127 -1637
FBL -6170 -7357
FCF1 7340 6857
FIP1L1 -5812 895
FTSJ1 -455 -5640
FTSJ3 -4598 507
FUS 3572 -1151
FYTTD1 1333 -1804
GAR1 1898 -2266
GCFC2 3958 -9381
GEMIN2 5303 -2681
GEMIN4 -7552 -9574
GEMIN5 -4535 -1880
GEMIN6 6030 3358
GEMIN7 6380 8281
GEMIN8 -5573 -3832
GLE1 -4843 7823
GNL3 6083 -7025
GPKOW -9719 -1803
GPRC5A 7880 -788
GSPT1 8890 4650
GSPT2 -5847 -5423
GTF2F1 -4830 5852
GTF2F2 7868 6958
GTF2H1 7542 -2446
GTF2H2 -5399 6904
GTF2H3 4878 4324
GTF2H4 -5429 1434
GTF2H5 8720 6947
GTPBP3 1593 -5870
H19 -9580 664
HBS1L 7391 6149
HEATR1 -5578 -8123
HNRNPA0 -9529 -7860
HNRNPA1 3354 397
HNRNPA2B1 4667 7450
HNRNPA3 -1012 -4071
HNRNPC 7228 7789
HNRNPD 6571 7988
HNRNPF 5903 5564
HNRNPH1 1972 -6223
HNRNPH2 9904 8822
HNRNPK 8272 8116
HNRNPL -7096 4605
HNRNPM 6832 5561
HNRNPR 4523 -3969
HNRNPU 1004 6971
HNRNPUL1 -5859 7093
HSD17B10 6214 6724
HSPA1A 8518 7125
HSPA8 -4222 -8984
HSPB1 2287 921
IGF2BP2 8476 8251
IGF2BP3 5881 7294
IMP3 -7393 -8684
IMP4 -7848 -9701
ISG20L2 732 5116
ISY1 4246 5548
KHSRP -1343 4290
KRR1 375 -5095
LAGE3 -496 -1881
LAS1L -9410 -9422
LCMT2 -7188 -8429
LSM1 6534 8084
LSM10 6657 5187
LSM11 -8793 -9154
LSM2 1382 3492
LSM3 3416 3430
LSM4 -371 -8518
LSM5 5128 -2157
LSM6 9036 9019
LSM7 -3217 -5789
LSM8 -3244 -6682
LTV1 7672 3314
MAGOH 2018 2858
MAGOHB -15 -4798
MAPK11 8895 6888
MAPK14 10026 9803
MAPKAPK2 -10648 4888
METTL1 6624 -7563
METTL14 1226 -1699
METTL3 -5357 -4146
MNAT1 -176 -2464
MPHOSPH10 5952 -4333
MPHOSPH6 5285 7932
MRM1 -6603 -8786
MRM2 6131 2818
MRM3 -7121 -6350
MT-ATP6 -5000 3338
MT-ATP8 -8176 7306
MT-CO1 2995 5163
MT-CO2 2723 3643
MT-CO3 307 4978
MT-CYB -2505 365
MT-ND1 -3359 -920
MT-ND2 -6325 -4137
MT-ND3 886 1784
MT-ND4 641 3660
MT-ND4L -5984 3290
MT-ND5 -2601 2772
MT-ND6 6472 6305
MT-RNR1 -4660 -192
MT-RNR2 -4826 4275
MT-TA -6672 -419
MT-TC -7569 5021
MT-TE -5714 -5335
MT-TF -7110 -3561
MT-TL1 -9034 -5535
MT-TL2 -9109 -5765
MT-TM -9517 -3774
MT-TN -7103 4345
MT-TP -10934 -10287
MT-TS1 -6094 4713
MT-TV -8649 -6121
MT-TY -8619 -11
MTERF4 -8800 -9005
MTO1 999 -5971
MTREX 4323 3278
MYC 8955 225
NAT10 -8029 -9599
NCBP1 2967 -1011
NCBP2 6179 -5809
NCL -4547 -7597
NDC1 -8939 -10351
NHP2 4484 -2384
NIP7 2396 -3614
NOB1 -6895 -7557
NOC4L -6324 -2308
NOL11 1925 -8448
NOL12 6226 5817
NOL6 -7959 -8898
NOL9 -6074 -8704
NOP10 8570 9831
NOP14 -6422 -8870
NOP2 -4106 -6672
NOP56 -5022 -9989
NOP58 4347 -8474
NSUN2 6784 5604
NSUN4 -5034 906
NSUN6 1243 -894
NT5C3B -282 -163
NUDT21 5825 -1517
NUP107 -8816 -8274
NUP133 -5348 776
NUP153 -6945 -3734
NUP155 -5317 -7756
NUP160 -2219 -8347
NUP188 -9248 -9221
NUP205 -7213 -7389
NUP210 -10535 -6252
NUP214 8257 8111
NUP35 -4124 -8851
NUP37 5728 6078
NUP42 2461 -1423
NUP43 -3773 -8208
NUP50 6620 2938
NUP54 6985 -5266
NUP58 9614 9817
NUP62 6407 -2545
NUP85 2286 -2781
NUP88 -8115 -8802
NUP93 -5242 -7982
NUP98 -1200 2149
NXF1 -608 2234
NXT1 -1449 -8016
OSGEP 1763 -4912
PABPC1 7203 5354
PABPN1 -4072 3194
PAIP1 7515 4405
PAN2 -1701 -1965
PAN3 -2162 2178
PAPOLA 9192 7603
PARN 1548 768
PATL1 6920 6800
PCBP1 5629 6989
PCBP2 5133 2907
PCF11 -5289 -3431
PDCD11 -10108 -7686
PDCD7 -8230 -4209
PELP1 -2643 -9040
PES1 4862 -993
PHAX -189 -4339
PHF5A 6812 -885
PLRG1 2116 -3547
PNO1 6437 -1058
PNRC2 3253 -175
POLDIP3 7174 8697
POLR2A -9475 -260
POLR2B 296 2423
POLR2C 3736 -612
POLR2D 6248 -1802
POLR2E 8013 8218
POLR2F 320 5451
POLR2G 1642 5704
POLR2H 4812 -2703
POLR2I 2083 1475
POLR2J 7302 8189
POLR2K 7511 2990
POLR2L 2955 6234
POM121 -9318 -4714
POM121C -10088 -6969
POP1 -4221 3622
POP4 448 503
POP5 -3954 -6233
POP7 5244 3201
PPIE -3976 -8580
PPIH -2348 -9524
PPIL1 3869 -914
PPIL3 2428 -2953
PPIL4 9010 5532
PPIL6 -1216 3854
PPP2CA 9766 8577
PPP2R1A 1997 5379
PPP2R2A 8980 3741
PPWD1 -2849 -9463
PQBP1 3324 -1210
PRCC -1878 5765
PRKCA 2691 1966
PRKCD 9710 9721
PRMT5 8094 964
PRORP 4765 6138
PRPF19 -2644 -6533
PRPF3 2997 -4873
PRPF31 -5256 -3612
PRPF38A 2493 3548
PRPF4 3698 5605
PRPF40A 7548 5462
PRPF6 -4712 -6722
PRPF8 -8762 -3939
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
PTBP1 -753 1627
PUF60 -3606 -1103
PUS1 -97 -3783
PUS3 8930 3207
PUS7 6651 -7722
PWP2 2407 4941
QTRT1 665 -9065
QTRT2 -2357 6052
RAE1 7170 7531
RAN 4957 -2873
RANBP2 457 512
RBM17 2718 2323
RBM22 4362 3651
RBM28 -10189 -7366
RBM5 -7598 -5397
RBM8A -7001 -875
RBMX -3048 -7584
RCL1 7236 2023
RIOK1 5183 3907
RIOK2 9357 84
RIOK3 9413 9229
RNGTT 5056 5997
RNMT -5125 -8418
RNPC3 1488 -4003
RNPS1 -6680 -6022
RPL10 631 -5696
RPL10A 1976 -6292
RPL11 1839 -3327
RPL12 2014 -5298
RPL13 2796 -3228
RPL13A -1728 -6706
RPL14 -1317 -5766
RPL15 5748 532
RPL17 143 -3476
RPL18 3381 -4456
RPL18A -1706 -4694
RPL19 -787 -4539
RPL21 276 -3918
RPL22 4761 -1687
RPL22L1 7231 -349
RPL23 3153 -1612
RPL23A -903 -7885
RPL24 1656 -1751
RPL26 842 -3483
RPL26L1 8258 7992
RPL27 1376 -417
RPL27A -1685 -3049
RPL28 2709 -1855
RPL29 1515 -3475
RPL3 -3958 -7454
RPL30 -2576 -5578
RPL31 -429 -3242
RPL32 219 -4702
RPL34 -1732 -6642
RPL35 -9119 -4134
RPL35A -112 -2513
RPL36 -4022 -4235
RPL36A 1606 -4363
RPL36AL 5944 -2052
RPL37 -6271 -3029
RPL37A -2362 -447
RPL38 -4515 -3500
RPL39 2137 350
RPL39L -7572 -3974
RPL4 4738 -2403
RPL41 -1299 -3511
RPL5 4105 -2796
RPL6 4935 -1237
RPL7 5143 -1272
RPL7A 1809 -1927
RPL8 1265 -1924
RPL9 700 -4879
RPLP0 6333 -1009
RPLP1 -1197 916
RPLP2 -4847 -5802
RPP14 6153 3856
RPP21 -2599 -4355
RPP25 -6016 -6916
RPP30 5972 -3194
RPP38 5051 -7716
RPP40 7453 -8690
RPPH1 -10249 2584
RPS10 -489 -4974
RPS11 -2316 -5641
RPS12 -4797 -7620
RPS13 5276 -1635
RPS14 -4624 -5393
RPS15 -1754 -3299
RPS15A 1269 -4048
RPS16 -2078 -6063
RPS17 -5045 -3169
RPS18 -7322 -6605
RPS19 -2989 -7057
RPS2 1634 -3308
RPS20 -2911 -6018
RPS21 -1933 -3896
RPS23 772 -4150
RPS24 6586 1001
RPS25 2600 -3817
RPS26 3527 -5041
RPS27 -7168 -6878
RPS27A -1868 -5386
RPS27L 7604 4230
RPS28 -2921 -3626
RPS29 -6817 -4617
RPS3 2486 -5123
RPS3A 5865 -3619
RPS4X -677 -7632
RPS4Y1 3815 574
RPS5 -1017 -5500
RPS6 2176 -3737
RPS7 1946 -2271
RPS8 3760 -769
RPS9 7673 4928
RPSA -3597 -5016
RRP1 1558 -5262
RRP36 -39 3862
RRP7A -4975 -3024
RRP9 72 -8148
RTCB 1630 402
RTRAF 9033 3844
SARNP 5977 4841
SART1 -4477 2748
SEC13 6324 5321
SEH1L 8372 -4799
SEM1 5210 6938
SENP3 1324 5191
SET -1893 -3953
SF1 -957 -776
SF3A1 -4845 -1590
SF3A2 -2057 -4222
SF3A3 -6070 -4371
SF3B1 -6314 -7788
SF3B2 -961 3041
SF3B3 -3460 -5778
SF3B4 6304 2101
SF3B5 3957 2082
SF3B6 9389 7275
SKIV2L -6791 -3013
SLBP 9114 4067
SLU7 5187 2778
SMG1 -6954 -2232
SMG5 976 389
SMG6 -8067 -2717
SMG7 2335 8556
SMG8 2241 1813
SMG9 799 4614
SMN1 4303 -2710
SMNDC1 8360 6062
SNORD3A -9792 1193
SNRNP200 -10060 -8022
SNRNP25 -4024 2871
SNRNP27 9639 6871
SNRNP35 8501 6259
SNRNP40 1284 -5844
SNRNP48 5789 -201
SNRNP70 1591 -7259
SNRPA 4770 4772
SNRPA1 -3497 -6914
SNRPB 1254 276
SNRPB2 8820 4272
SNRPC 7419 4178
SNRPD1 8426 4644
SNRPD2 -4073 -3879
SNRPD3 6844 745
SNRPE 6969 1616
SNRPF 3252 3096
SNRPG 5304 5185
SNRPN -7415 -8119
SNU13 -139 -5644
SNUPN 6232 9120
SNW1 8504 6624
SRRM1 977 -1060
SRRM2 -5395 -2617
SRRT -561 -4240
SRSF1 2345 3608
SRSF10 2503 -5384
SRSF11 -2925 -8667
SRSF2 -980 -5411
SRSF3 4661 -84
SRSF4 -1189 7081
SRSF5 -6572 -10068
SRSF6 1053 -4142
SRSF7 -2297 -6770
SRSF9 4604 8368
SUGP1 1007 2664
SUPT5H -6280 -3833
SYF2 6381 5757
SYMPK -1713 -3972
TBL3 -4163 -4984
TEX10 -728 -6521
TFB1M -7154 -8810
TFIP11 -4255 2721
TGS1 410 -2742
THADA -8506 -7070
THG1L -7548 -6446
THOC1 -2501 -7809
THOC2 6781 2105
THOC3 -2652 -9798
THOC5 3902 7523
THOC6 7350 470
THOC7 9670 7814
THUMPD1 48 -9681
TNFSF13 8815 9829
TNKS1BP1 -4943 -5891
TNPO1 3727 5370
TP53RK -9891 -9946
TPR -4478 -7012
TPRKB 6367 -2002
TRA2B 7743 2163
TRDMT1 7035 3966
TRIT1 9044 2582
TRMT1 3456 -3841
TRMT10A 9347 9312
TRMT10C 7114 -3353
TRMT11 250 -10001
TRMT112 3035 510
TRMT12 -2480 4002
TRMT13 1965 -8070
TRMT44 -2997 -5658
TRMT5 6152 5619
TRMT6 4609 8643
TRMT61A -6084 -9790
TRMT61B 1974 -4089
TRMT9B 6748 9539
TRMU -4812 -7987
TRNT1 2475 -5086
TSEN15 2188 -5612
TSEN2 -4079 -6442
TSEN34 7183 6035
TSEN54 -10876 -10491
TSR1 4712 -7123
TSR3 -1220 3240
TTC37 -250 -4784
TXNL4A 6216 7901
TYW1 1217 -7255
TYW3 4045 -6014
TYW5 -1228 4793
U2AF1 1457 5355
U2AF1L4 5546 189
U2AF2 2659 1959
U2SURP 336 -1588
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UPF1 -7508 3221
UPF2 2139 1512
UPF3A -8945 -6621
UPF3B -3779 -4482
URM1 966 1971
USP39 -4919 7114
UTP11 8322 6927
UTP14A 2019 2472
UTP14C -713 1477
UTP15 2657 -7360
UTP18 6514 7406
UTP20 -1589 -7369
UTP3 2595 699
UTP4 -736 -9058
UTP6 6320 367
WBP11 -6060 -6760
WBP4 8294 5691
WDR12 7691 8132
WDR18 3545 -3386
WDR3 -1131 -931
WDR33 -5150 -512
WDR36 2502 -1850
WDR4 -8875 -9070
WDR43 2464 -3068
WDR46 -6771 -6887
WDR61 5735 -802
WDR75 4353 -8698
WDR77 1621 -8226
WTAP 7894 2693
XAB2 -4156 -3462
XPO1 7772 4672
XPOT 831 3094
XRN1 -134 -5521
XRN2 10201 10472
YBX1 -2475 4042
YWHAB 9116 6191
YWHAZ 7112 6341
ZBTB8OS 7598 7798
ZC3H11A -1840 -3112
ZCRB1 6828 4542
ZFP36 9065 5699
ZFP36L1 8369 3895
ZMAT5 7423 9392
ZNF473 -6571 -8194
ZRSR2 -436 -1731



FCERI mediated MAPK activation

FCERI mediated MAPK activation
metric value
setSize 89
pMANOVA 2.28e-14
p.adjustMANOVA 7.96e-13
s.dist 0.318
s.low.CRP 0.152
s.high.CRP -0.279
p.low.CRP 0.0129
p.high.CRP 5.51e-06




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
FOS 7518 2641
GRAP2 -2556 4557
GRB2 9960 10389
HRAS 2906 -3843
IGHE -4940 -4979
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
JUN 481 -1015
KRAS 4388 5328
LAT -8158 -10401
LCP2 5338 -3004
LYN 8483 8583
MAP2K4 5525 7430
MAP2K7 -1568 2972
MAP3K1 380 8292
MAPK1 -1086 9427
MAPK10 6946 6199
MAPK3 9769 9676
MAPK8 -794 -7374
MAPK9 -6911 1519
NRAS 8582 7708
PAK1 10129 7653
PAK2 9098 8874
PLCG1 -5836 -10187
PLCG2 -6227 6708
RAC1 9345 9946
SHC1 3101 5292
SOS1 2394 -4661
SYK 9750 10350
VAV1 6299 7892
VAV2 -9043 2054
VAV3 -7486 7780



Disease

Disease
metric value
setSize 1339
pMANOVA 2.57e-14
p.adjustMANOVA 8.76e-13
s.dist 0.16
s.low.CRP 0.125
s.high.CRP 0.101
p.low.CRP 1.99e-14
p.high.CRP 6.27e-10




Top 20 genes
Gene low CRP high CRP
CSF2RA 10368 10661
IDH1 10341 10649
ADAMTS2 10314 10665
FZD5 10298 10651
CTSA 10310 10636
VCAN 10280 10667
WASF1 10267 10673
F12 10253 10643
CD36 10363 10493
CYP1B1 10171 10672
HRH2 10336 10492
TALDO1 10319 10395
CD163 10141 10559
GUCY2C 10157 10506
FCGR1A 10365 10249
ADM 10088 10504
AP1S1 10021 10574
CYFIP1 10019 10571
GNG10 10307 10252
PRKACA 9995 10558

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAAS -4220.0 -2848.0
ABCA1 4951.0 6830.0
ABCA3 -10372.0 -9956.0
ABCB4 -8019.0 -3110.0
ABCB6 7279.0 5608.0
ABCC2 -2800.0 -2702.0
ABCC6 1209.0 3452.0
ABCC9 -4895.0 -1889.0
ABCD1 5996.0 7409.0
ABCD4 -6320.0 -5354.0
ABCG8 8787.0 2935.0
ABI1 7076.0 8607.0
ABI2 -8604.0 -8517.0
ABL1 -8248.0 3812.0
ACACA 829.0 7444.0
ACTB 10142.0 9915.0
ACTG1 8859.0 9583.0
ACTR2 9004.0 9240.0
ACTR3 9818.0 8294.0
ACY1 5098.0 -5857.0
ADAM10 9652.0 10284.0
ADAM17 4487.0 10398.0
ADAMTS1 -10925.0 -6738.0
ADAMTS10 -10554.0 -9120.0
ADAMTS13 -717.0 -2609.0
ADAMTS14 -9572.0 -7264.0
ADAMTS16 -5486.0 -6100.0
ADAMTS17 1716.0 -5751.0
ADAMTS2 10314.0 10665.0
ADAMTS4 -9692.0 -8176.0
ADAMTS5 1277.0 -7082.0
ADAMTS6 -8817.0 -299.0
ADAMTSL3 -1249.0 -436.0
ADAMTSL4 8696.0 8969.0
ADAMTSL5 1742.0 -9869.0
ADCY2 -3835.0 2899.0
ADCY3 9752.0 10224.0
ADCY4 4464.0 2329.0
ADCY5 -10012.0 -4366.0
ADCY6 -5852.0 -3739.0
ADCY7 -9455.0 -1458.0
ADCY9 -8919.0 1933.0
ADM 10088.0 10504.0
ADM2 9999.0 5782.0
ADORA2A -1381.0 -1440.0
ADORA2B 6712.0 10334.0
ADRB1 -10531.0 -6313.0
ADRB2 -10762.0 -9843.0
AGGF1 6783.0 9088.0
AGK -8892.0 -10246.0
AGRN -10089.0 -10536.0
AGTRAP 9514.0 10270.0
AHCY 419.0 327.0
AHCYL1 4949.0 8470.0
AKAP9 -302.0 -3464.0
AKT1 -5096.0 2421.0
AKT1S1 6861.0 8235.0
AKT2 -7693.0 3004.0
AKT3 -8346.0 -9755.0
ALDOB -4339.0 3084.0
ALG1 -7518.0 -4565.0
ALG11 -4114.0 415.0
ALG12 -1788.0 -1158.0
ALG13 1354.0 -7430.0
ALG14 9158.0 8578.0
ALG2 6463.0 2704.0
ALG3 5995.0 -2482.0
ALG6 7443.0 7333.0
ALG8 7380.0 705.0
ALG9 -3668.0 -3824.0
AMER1 -8746.0 -9063.0
AMN -1633.0 -2567.0
ANAPC1 -9296.0 -9659.0
ANAPC10 -527.0 1902.0
ANAPC11 5022.0 6085.0
ANAPC15 10210.0 10243.0
ANAPC16 5335.0 -809.0
ANAPC2 -5345.0 -6689.0
ANAPC4 2261.0 -3709.0
ANAPC5 -8128.0 -6414.0
ANAPC7 3531.0 1520.0
ANTXR2 4925.0 7379.0
AP1B1 7607.0 10260.0
AP1G1 -1729.0 6706.0
AP1M1 392.0 8050.0
AP1M2 1215.0 549.0
AP1S1 10021.0 10574.0
AP1S2 7206.0 -5666.0
AP1S3 -7437.0 3269.0
AP2A1 -5326.0 9611.0
AP2A2 5529.0 9467.0
AP2B1 -8369.0 3155.0
AP2M1 7928.0 9269.0
AP2S1 8593.0 9630.0
AP3B1 8318.0 10381.0
APBB1IP 10051.0 8873.0
APC -2802.0 3982.0
APH1A 3292.0 4183.0
APH1B 5962.0 8800.0
APOBEC3G -10260.0 -9887.0
APP 10085.0 9961.0
ARAF 939.0 2823.0
AREG -5505.0 9162.0
ARF1 9085.0 10196.0
ARID4A 4572.0 3700.0
ARID4B 110.0 -330.0
ARPC1A 9171.0 9991.0
ARPC1B 9189.0 10351.0
ARPC2 7187.0 8262.0
ARPC3 9674.0 9506.0
ARPC4 7777.0 8635.0
ARPC5 9932.0 9762.0
ARRB1 -5720.0 3058.0
ARRB2 8232.0 9058.0
ARSB 8290.0 9046.0
ATG7 9954.0 8519.0
ATP1A1 2079.0 5849.0
ATP1A3 -10629.0 -10011.0
ATP1A4 1140.0 1500.0
ATP1B1 -8554.0 -5287.0
ATP1B2 6531.0 7889.0
ATP1B3 -1519.0 3938.0
ATP6V1H 8628.0 8476.0
AVPR1A -3313.0 546.0
AVPR2 3307.0 -4195.0
AXIN1 -10501.0 -8999.0
B2M 58.0 -7420.0
B3GALT6 -4374.0 -6890.0
B3GAT3 -948.0 -2368.0
B3GLCT -10293.0 -8087.0
B4GALT1 -3872.0 6820.0
B4GALT7 -2683.0 -6283.0
B4GAT1 -1787.0 -2379.0
BAD 5612.0 7891.0
BAG4 8401.0 10165.0
BAIAP2 -5772.0 -4014.0
BANF1 337.0 -1951.0
BCL2L11 7146.0 9131.0
BCR -10783.0 -4877.0
BECN1 8030.0 6913.0
BIN2 -8436.0 8915.0
BRAF -5814.0 3049.0
BRAP 6562.0 6795.0
BRD4 -4028.0 7873.0
BRK1 5824.0 7761.0
BRMS1 6202.0 5201.0
BSG 9321.0 9898.0
BTD -10140.0 -10299.0
BTK 5823.0 9633.0
BTRC -7062.0 1812.0
C1GALT1 5940.0 -6509.0
C1GALT1C1 9935.0 9105.0
C1QBP 6269.0 -1813.0
C3 -10957.0 -10571.0
C3AR1 8008.0 9376.0
CALCRL 9216.0 6270.0
CALM1 -4337.0 1051.0
CALR 8310.0 6954.0
CAMK2D -5436.0 -9961.0
CAMK2G 3580.0 -6522.0
CAMK4 918.0 -10447.0
CANX 7507.0 7257.0
CAPN1 5416.0 9742.0
CAPN2 -1203.0 3962.0
CAPNS1 7336.0 9305.0
CASP1 9611.0 2857.0
CASP8 -9202.0 -9212.0
CASP9 4638.0 9486.0
CAST 8266.0 9832.0
CBL 1852.0 8579.0
CBLL1 -3279.0 -5557.0
CBX1 1082.0 4244.0
CCNC 8958.0 4374.0
CCND1 -3107.0 -2342.0
CCND2 -8332.0 -10449.0
CCND3 -655.0 9164.0
CCNE1 -6448.0 -9772.0
CCNE2 5682.0 6596.0
CCNH 1319.0 6144.0
CCNK -2710.0 4495.0
CCNT1 -9147.0 -4867.0
CCNT2 -206.0 -1240.0
CCR5 -9310.0 -7370.0
CD14 10063.0 10306.0
CD163 10141.0 10559.0
CD19 -5755.0 -965.0
CD247 -10994.0 -10515.0
CD28 -328.0 -10542.0
CD320 -6807.0 -9725.0
CD36 10363.0 10493.0
CD3G -8283.0 -10568.0
CD4 1506.0 -6863.0
CD80 -7610.0 -7443.0
CD86 6726.0 -1548.0
CD8B 2861.0 -10223.0
CD9 7795.0 5893.0
CDC16 -4738.0 -1477.0
CDC23 -5476.0 -5775.0
CDC25A 4343.0 4765.0
CDC25B -8795.0 -10346.0
CDC26 7265.0 4357.0
CDC27 4432.0 3370.0
CDC37 2418.0 5331.0
CDC42 9246.0 8570.0
CDH1 -10326.0 -6171.0
CDK2 -3816.0 1587.0
CDK4 -5111.0 -8839.0
CDK5 9150.0 10447.0
CDK5R1 -3681.0 4421.0
CDK6 -80.0 -6922.0
CDK7 6763.0 7641.0
CDK8 -1289.0 2360.0
CDK9 -10105.0 1292.0
CDKN1A -1680.0 4429.0
CDKN1B -8668.0 -5917.0
CDKN1C -11020.0 -8740.0
CDKN2A -4195.0 308.0
CEBPD 8189.0 10136.0
CFP 8398.0 8912.0
CHD3 -9906.0 -8152.0
CHD4 -9329.0 -2257.0
CHMP1A 826.0 5464.0
CHMP2A 9715.0 9488.0
CHMP2B 8303.0 5566.0
CHMP3 8652.0 9021.0
CHMP4A 6441.0 5030.0
CHMP4B 9666.0 9765.0
CHMP5 7394.0 5917.0
CHMP6 -3413.0 6801.0
CHMP7 -3563.0 -7134.0
CHST14 -8335.0 2604.0
CHST6 1538.0 -3637.0
CHSY1 8912.0 8026.0
CHUK 9608.0 9191.0
CLCN6 1006.0 2480.0
CLTA 9206.0 9264.0
CLTC 9482.0 10359.0
CNKSR1 3442.0 -9142.0
CNKSR2 1572.0 -137.0
CNTRL -3763.0 -2140.0
COMT 8254.0 9173.0
CORO1A -3.0 3919.0
CP -10052.0 1836.0
CPSF4 -8827.0 -4896.0
CPSF6 3400.0 -4549.0
CRBN 3120.0 -3981.0
CREB1 2938.0 -595.0
CREBBP -9358.0 1958.0
CRHR2 -7686.0 823.0
CRK 9214.0 9663.0
CSF2RA 10368.0 10661.0
CSF2RB 9224.0 5475.0
CSK -2015.0 6501.0
CSNK1A1 8036.0 9059.0
CSPG4 -7234.0 -3407.0
CTBP1 -9138.0 -4408.0
CTBP2 -7717.0 6437.0
CTDP1 -5339.0 6650.0
CTNNB1 1446.0 7186.0
CTNND1 -511.0 -4113.0
CTSA 10310.0 10636.0
CTSG 9668.0 2004.0
CTSL -5492.0 6157.0
CUBN 3637.0 -8340.0
CUL1 7475.0 -10175.0
CUL5 8446.0 4656.0
CUX1 7781.0 10485.0
CXCR4 -1821.0 1007.0
CYBA 5409.0 8122.0
CYFIP1 10019.0 10571.0
CYFIP2 -10388.0 -8406.0
CYP1B1 10171.0 10672.0
CYP27A1 5784.0 2844.0
CYP2R1 -9251.0 -308.0
CYP2U1 -10657.0 -10266.0
CYP4F22 -10929.0 -10406.0
CYP7B1 -6090.0 -4311.0
CYSLTR1 211.0 -7053.0
CYSLTR2 1991.0 -7665.0
DAD1 7699.0 6258.0
DAG1 -7765.0 -3574.0
DAXX -9382.0 -5524.0
DBP -8458.0 -9488.0
DCXR 3537.0 -1189.0
DDOST 5768.0 8734.0
DDX5 -9939.0 -6160.0
DERL1 -5393.0 -6496.0
DERL2 5626.0 4860.0
DERL3 -7423.0 -6029.0
DHDDS -6182.0 1919.0
DLL1 -10127.0 -10367.0
DNAJC3 9070.0 9215.0
DOCK1 2337.0 9856.0
DOCK2 3702.0 9336.0
DOLK -7816.0 -482.0
DPAGT1 6371.0 3303.0
DPEP2 -7575.0 -7040.0
DPEP3 -509.0 -9183.0
DPM1 5700.0 4181.0
DPM2 5599.0 2835.0
DPM3 3402.0 1010.0
DUSP10 -1562.0 1761.0
DUSP16 -4653.0 -6088.0
DUSP6 7156.0 -2241.0
DUSP7 -5905.0 -3113.0
DUSP8 -9809.0 -10041.0
DUT -1230.0 -4662.0
DVL1 427.0 -3597.0
DVL2 -9587.0 -8307.0
DVL3 -7366.0 7767.0
DYNC1H1 -9811.0 -4718.0
DYNC1I1 378.0 6338.0
DYNC1I2 8978.0 9397.0
DYNC1LI1 8227.0 7194.0
DYNC1LI2 909.0 7271.0
DYNLL1 6414.0 7208.0
DYNLL2 -5827.0 -2261.0
E2F1 807.0 4632.0
E2F2 7520.0 9981.0
E2F3 -1851.0 7284.0
EDEM2 9361.0 9706.0
EED -2060.0 -3357.0
EEF2 -3419.0 -1260.0
EGF 8136.0 8196.0
EIF2AK2 -9087.0 -7734.0
ELK1 5371.0 2922.0
ELL -5115.0 438.0
ELMO1 3674.0 6433.0
ELMO2 -6937.0 7218.0
ELOA 8862.0 8052.0
ELOB 7369.0 8033.0
ELOC 7870.0 9351.0
ENO1 10259.0 9450.0
ENTPD1 9787.0 9358.0
ENTPD5 -3775.0 -3687.0
EP300 -2315.0 7280.0
EPM2A -6288.0 -8172.0
EPS15 5113.0 6773.0
ERBB2 -11003.0 -9975.0
ERBB3 -597.0 1233.0
ERBIN -1073.0 2273.0
ERCC2 -974.0 6111.0
ERCC3 -8528.0 -1350.0
EREG -2190.0 5005.0
ERLEC1 3753.0 5744.0
ERLIN1 9922.0 10112.0
ERLIN2 8606.0 10317.0
ESR1 -6841.0 -8227.0
ESR2 -5996.0 -9163.0
ETV6 8063.0 6333.0
EXT1 5076.0 8271.0
EXT2 -1420.0 -555.0
EZH2 -3198.0 -8251.0
F12 10253.0 10643.0
F8 7904.0 8494.0
FADD -3902.0 4370.0
FAM114A2 6780.0 6732.0
FAM131B -4979.0 2182.0
FASLG -10999.0 -10620.0
FAU -1127.0 -1637.0
FBXW7 -8232.0 -6782.0
FCGR1A 10365.0 10249.0
FCGR2A 9647.0 9000.0
FCGR3A -11031.0 -7169.0
FDX1 6054.0 -653.0
FDX2 -1694.0 -7020.0
FDXR 9148.0 3744.0
FEN1 -5020.0 -7778.0
FGF2 8825.0 5391.0
FGF22 -4199.0 -8205.0
FGF23 1297.0 -7622.0
FGF7 -1811.0 -5146.0
FGF9 -7810.0 -8061.0
FGFR1 -9793.0 -95.0
FGFR1OP2 9849.0 7246.0
FGFR2 -10432.0 -10034.0
FGFR4 -1488.0 -4510.0
FGR 7776.0 10127.0
FIP1L1 -5812.0 895.0
FKBP1A 10270.0 9273.0
FKBP4 -833.0 414.0
FMO3 2263.0 1957.0
FN1 9912.0 6648.0
FOXO1 -8890.0 -9341.0
FOXO3 2533.0 10065.0
FOXO4 -2621.0 6949.0
FOXO6 -10497.0 -4221.0
FRS2 52.0 35.0
FURIN 7688.0 10324.0
FUT8 -9860.0 -5220.0
FXR1 5746.0 6887.0
FXYD1 -1553.0 -3380.0
FXYD2 -6794.0 -5885.0
FXYD3 -10548.0 -2169.0
FXYD6 8713.0 6059.0
FXYD7 1589.0 -7774.0
FYN -10683.0 -7016.0
FZD4 -10151.0 -6695.0
FZD5 10298.0 10651.0
FZD6 -3983.0 -5942.0
FZD7 -9241.0 -5379.0
FZD8 -9803.0 -264.0
FZR1 -6086.0 -3255.0
G6PC 7956.0 7740.0
G6PC3 5886.0 5835.0
GAA 8463.0 8516.0
GAB1 3626.0 8241.0
GAB2 6405.0 10289.0
GALE 1797.0 8288.0
GALK1 8209.0 10332.0
GALNS 6891.0 7996.0
GALNT1 7857.0 7854.0
GALNT12 -6226.0 -8838.0
GALNT3 -5321.0 762.0
GALT -1401.0 -8485.0
GANAB -7302.0 2200.0
GATAD2A -7926.0 1424.0
GATAD2B -7823.0 241.0
GBE1 8804.0 8490.0
GCK -553.0 1673.0
GCLC -9254.0 -6727.0
GCLM 1993.0 6688.0
GFPT1 -648.0 -5626.0
GGCX -4196.0 7376.0
GGT1 10054.0 10098.0
GGT5 -401.0 3250.0
GIPR -9804.0 -10690.0
GLB1 9395.0 10125.0
GNAI1 5305.0 5103.0
GNAI2 8368.0 9095.0
GNAI3 9913.0 8209.0
GNAS 4056.0 6487.0
GNAZ -6426.0 -852.0
GNB1 7951.0 9297.0
GNB2 8365.0 8530.0
GNB3 9486.0 -8169.0
GNB4 9757.0 8191.0
GNB5 -762.0 -205.0
GNE 1982.0 -5161.0
GNG10 10307.0 10252.0
GNG11 4608.0 5846.0
GNG2 -10288.0 -2836.0
GNG3 6662.0 1225.0
GNG4 -1513.0 -1627.0
GNG5 9805.0 9666.0
GNG7 -5188.0 -5336.0
GNG8 -5154.0 2284.0
GNGT2 -10923.0 -9575.0
GNS 9753.0 10593.0
GOLGA2 -6652.0 7914.0
GOLGA4 -4344.0 -1102.0
GP1BA 982.0 6984.0
GP1BB 1443.0 8042.0
GP5 2423.0 -4169.0
GP9 5315.0 8099.0
GPBAR1 1812.0 -9767.0
GPC1 -7727.0 -2335.0
GPC2 -1014.0 -9320.0
GPC4 -5640.0 -8045.0
GPR15 1481.0 -10196.0
GPR150 -7161.0 -9626.0
GPR20 -11005.0 -9509.0
GPR25 -10356.0 -9393.0
GPR27 9856.0 10288.0
GPR83 -6758.0 2713.0
GPR84 10189.0 9570.0
GPS2 -3941.0 -2386.0
GRB2 9960.0 10389.0
GRSF1 8535.0 5101.0
GSK3A 5437.0 8275.0
GSK3B 4111.0 7308.0
GSS 3136.0 1464.0
GTF2A1 3704.0 2800.0
GTF2A2 9512.0 8125.0
GTF2B 7989.0 3735.0
GTF2E1 -1207.0 4177.0
GTF2E2 6164.0 7151.0
GTF2F1 -4830.0 5852.0
GTF2F2 7868.0 6958.0
GTF2H1 7542.0 -2446.0
GTF2H2 -5399.0 6904.0
GTF2H3 4878.0 4324.0
GTF2H4 -5429.0 1434.0
GTF2H5 8720.0 6947.0
GUCY2C 10157.0 10506.0
GUSB 3888.0 9979.0
GYG1 9967.0 10059.0
GYS1 7108.0 8360.0
H2AC11 1918.0 8407.0
H2AC20 -3045.0 2635.0
H2AC6 4729.0 7926.0
H2AW -10307.0 -8947.0
H2BC11 3513.0 8859.0
H2BC12 7081.0 10193.0
H2BC15 -7054.0 7711.0
H2BC17 2507.0 9311.0
H2BC18 4067.0 6699.0
H2BC21 8299.0 10036.0
H2BC4 1910.0 8229.0
H2BC5 3700.0 7898.0
H2BC9 1386.0 3852.0
H2BU1 -7775.0 -6129.0
H3C15 182.5 4598.5
HBEGF -922.0 4467.0
HCK 10073.0 9850.0
HDAC1 -2168.0 4381.0
HDAC10 2072.0 1157.0
HDAC11 2954.0 4635.0
HDAC2 9181.0 5219.0
HDAC3 7060.0 7743.0
HDAC4 9252.0 9753.0
HDAC5 -1101.0 439.0
HDAC6 -8079.0 -3650.0
HDAC7 6776.0 5329.0
HDAC8 2416.0 8799.0
HDAC9 6238.0 -23.0
HES1 -8727.0 -5967.0
HEXA 1499.0 2409.0
HEXB 9686.0 9967.0
HGF 8952.0 9949.0
HGS 813.0 5448.0
HGSNAT 2790.0 2412.0
HHAT -7344.0 -8847.0
HK1 9556.0 10256.0
HLA-A -3294.0 -7605.0
HLCS -10771.0 -6963.0
HMG20B -1431.0 5212.0
HMGA1 5990.0 -2616.0
HNRNPK 8272.0 8116.0
HRAS 2906.0 -3843.0
HRH2 10336.0 10492.0
HSP90AA1 5650.0 1245.0
HSP90AB1 4616.0 -5342.0
HSPA1A 8518.0 7125.0
HSPG2 -8564.0 -3950.0
HTR6 5090.0 -3526.0
HTR7 -2291.0 -4337.0
HYAL1 -3857.0 4281.0
ICOS 2053.0 -9847.0
IDH1 10341.0 10649.0
IDS -8382.0 -5645.0
IDUA 1922.0 -6114.0
IFNAR1 9540.0 8356.0
IFNAR2 5852.0 8082.0
IFNGR1 10033.0 10368.0
IFNGR2 10106.0 10294.0
IGHG1 -3727.0 -9610.0
IGHG2 -2988.0 -6697.0
IGHG3 3688.0 -4504.0
IGHG4 -6480.0 -3573.0
IGHV1-2 7949.0 -2404.0
IGHV1-46 1645.0 -7097.0
IGHV1-69 -473.0 -3585.0
IGHV2-5 -761.0 -7784.0
IGHV2-70 -5110.0 -2783.0
IGHV3-11 6603.0 -6880.0
IGHV3-13 -4367.0 -5652.0
IGHV3-23 5184.0 -7276.0
IGHV3-30 6205.0 -8897.0
IGHV3-33 -1859.0 -6548.0
IGHV3-48 1158.0 -4630.0
IGHV3-53 439.0 -4325.0
IGHV3-7 2687.0 -5396.0
IGHV4-34 -3831.0 -5446.0
IGHV4-39 -3715.0 -8660.0
IGHV4-59 1427.0 -4638.0
IGKC 3871.0 -8235.0
IGKV1-12 4565.0 -9660.0
IGKV1-16 4776.0 -5235.0
IGKV1-17 5659.0 -4913.0
IGKV1-33 5570.0 -6751.0
IGKV1-5 5340.0 -9482.0
IGKV1D-39 2361.0 -3975.0
IGKV2-28 600.0 -6240.0
IGKV2-30 2124.0 -5952.0
IGKV2D-28 -8241.0 -7171.0
IGKV3-11 4335.0 -8929.0
IGKV3-15 3182.0 -9110.0
IGKV3-20 3477.0 -8253.0
IGKV3D-20 -604.0 -487.0
IGKV4-1 5759.0 -5700.0
IGKV5-2 3670.0 -6960.0
IGLC1 -2564.0 -7780.0
IGLC2 -3391.0 -9023.0
IGLC3 -211.0 -3454.0
IGLC7 -5718.0 -8734.0
IGLV1-36 -1581.0 -5381.0
IGLV1-40 -5815.0 -8593.0
IGLV1-44 3169.0 -7580.0
IGLV1-47 -657.0 -7558.0
IGLV1-51 -1719.0 -7074.0
IGLV10-54 3553.0 -6006.0
IGLV2-11 1826.0 -4201.0
IGLV2-14 -4545.0 -8212.0
IGLV2-18 5165.0 -4216.0
IGLV2-23 4476.0 -5875.0
IGLV2-8 4817.0 -8917.0
IGLV3-1 -5764.0 -8993.0
IGLV3-12 -6620.0 -5525.0
IGLV3-19 2884.0 -7478.0
IGLV3-21 -1967.0 -5619.0
IGLV3-25 -5461.0 -6576.0
IGLV3-27 -8634.0 -4435.0
IGLV4-69 -1909.0 -6359.0
IGLV5-45 5252.0 -9604.0
IGLV6-57 4672.0 -7639.0
IGLV7-43 165.0 2135.0
IGLV7-46 6144.0 -6715.0
IGLV8-61 3943.0 -3641.0
IKBKB -6356.0 -1160.0
IKBKG -595.0 7203.0
IL10 9226.0 10431.0
IL18 7946.0 10001.0
IL1B 9843.0 323.0
IL1R1 8837.0 9561.0
IL6R 9817.0 7220.0
IMPDH1 10166.0 10137.0
IMPDH2 543.0 -9049.0
INSL3 7721.0 3553.0
IPO5 -432.0 -8907.0
IQGAP1 6734.0 9841.0
IRS1 1115.0 1691.0
IRS2 3826.0 10432.0
ISG15 -9687.0 -10630.0
ITGA2B 8831.0 9692.0
ITGA4 -8536.0 -9695.0
ITGB1 -332.0 1996.0
ITGB3 7696.0 8680.0
ITPR1 -9755.0 -3689.0
ITPR2 4786.0 9335.0
ITPR3 -8426.0 -7902.0
JAG1 8281.0 9220.0
JAG2 -6115.0 -8753.0
JAK1 -10460.0 -6095.0
JAK2 8894.0 -2339.0
JAK3 9823.0 8824.0
JUN 481.0 -1015.0
KANK1 3444.0 -6788.0
KAT2A -5724.0 -9539.0
KAT2B 629.0 -1039.0
KCNJ11 -141.0 2587.0
KDM1A -8434.0 -1742.0
KDM7A 7096.0 6765.0
KHK -9079.0 -9026.0
KIAA1549 690.0 5071.0
KIT -10558.0 -7492.0
KL 5898.0 10387.0
KLKB1 -280.0 -5832.0
KPNA1 3096.0 3012.0
KPNA2 -2381.0 -2173.0
KPNA3 4515.0 4501.0
KPNA4 3199.0 4366.0
KPNA5 -5243.0 -10327.0
KPNB1 67.0 557.0
KRAS 4388.0 5328.0
KREMEN1 10089.0 10339.0
KREMEN2 -7711.0 -1116.0
KSR1 -1842.0 5006.0
KSR2 -9743.0 -472.0
LARGE1 -8590.0 -9364.0
LCK -9185.0 -10569.0
LFNG -9696.0 -5364.0
LIG1 -6259.0 -9583.0
LIG4 5209.0 7346.0
LMBRD1 8494.0 7421.0
LMNA -2386.0 2195.0
LMNB1 10350.0 10018.0
LRP5 5604.0 4248.0
LRP6 -1143.0 -3132.0
LRRFIP1 7097.0 6307.0
LTF 9350.0 4940.0
LY96 9677.0 9581.0
LYN 8483.0 8583.0
MAGT1 4037.0 5258.0
MAML1 -2430.0 5472.0
MAML2 -1546.0 -1346.0
MAML3 7860.0 10038.0
MAMLD1 3618.0 -4081.0
MAN1B1 -3746.0 -4312.0
MAN2A1 1336.0 -1270.0
MAOA 9730.0 10208.0
MAP1LC3B 6882.0 8047.0
MAP2K1 8861.0 10365.0
MAP2K2 4832.0 6767.0
MAP2K3 8777.0 8502.0
MAP2K4 5525.0 7430.0
MAP2K6 8704.0 10103.0
MAP2K7 -1568.0 2972.0
MAP3K11 5048.0 8330.0
MAPK1 -1086.0 9427.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MAPK8 -794.0 -7374.0
MAPKAP1 7373.0 6742.0
MARK3 9015.0 9517.0
MBD3 3015.0 -3753.0
MC1R -10499.0 -9166.0
MCCC1 -2805.0 -1715.0
MCCC2 -5277.0 -8761.0
MDM2 3788.0 6943.0
MECP2 -10291.0 -9265.0
MEFV 9121.0 9560.0
MGAT1 362.0 7982.0
MGAT2 -3625.0 2214.0
MGAT4A -482.0 -6981.0
MGAT4B 9034.0 9077.0
MGAT4C 1409.0 -1128.0
MGAT5 -8963.0 1454.0
MIB1 -4278.0 -6206.0
MIB2 -8918.0 -9157.0
MLH1 -3740.0 2908.0
MLST8 308.0 1090.0
MMAA -4030.0 -6839.0
MMAB -4078.0 -4012.0
MMACHC -1466.0 -4890.0
MMADHC 8041.0 6677.0
MMUT 8024.0 6667.0
MNAT1 -176.0 -2464.0
MOGS -5070.0 -3156.0
MPDU1 8992.0 9338.0
MPI -2165.0 -8742.0
MPRIP -9846.0 -9238.0
MRAS -10360.0 23.0
MRC1 -2922.0 4812.0
MSH2 -9679.0 -8502.0
MSH3 4526.0 7876.0
MSH6 4366.0 651.0
MTA1 1434.0 -1530.0
MTA2 -7881.0 118.0
MTA3 -6020.0 -3219.0
MTOR -10624.0 -2672.0
MTR -10199.0 -10364.0
MTRR 2273.0 4990.0
MUC1 9675.0 8255.0
MUC12 -9171.0 -8879.0
MUC16 -3838.0 -3439.0
MUC20 3464.0 -5169.0
MUC4 244.0 775.0
MUC5B -6905.0 -2911.0
MUC6 -1039.0 -983.0
MUCL1 -1284.0 2959.0
MUTYH -7071.0 -8677.0
MVB12A 7215.0 9463.0
MVB12B 2169.0 4830.0
MYC 8955.0 225.0
MYD88 8926.0 8524.0
MYH9 -3200.0 7267.0
MYO10 9262.0 10223.0
MYO18A -9625.0 -2549.0
MYO1C 4706.0 3451.0
MYO5A 2173.0 8638.0
MYO9B -3670.0 7822.0
NAGLU -8909.0 -1343.0
NAPEPLD -3285.0 -4720.0
NCBP1 2967.0 -1011.0
NCBP2 6179.0 -5809.0
NCK1 -8084.0 -8497.0
NCKAP1 2316.0 10142.0
NCKAP1L 1901.0 10162.0
NCKIPSD 289.0 -2712.0
NCOR1 -1531.0 9348.0
NCOR2 -2998.0 10117.0
NCSTN 9915.0 10361.0
NDC1 -8939.0 -10351.0
NEDD4L 4410.0 9142.0
NEIL1 -8471.0 -6662.0
NEIL3 2971.0 3086.0
NELFA -1095.0 -3868.0
NELFB -5387.0 1018.0
NELFCD -2611.0 547.0
NELFE 3683.0 6411.0
NEU1 9609.0 10026.0
NEURL1 -11014.0 -8368.0
NEURL1B -8314.0 -576.0
NF1 -3172.0 5202.0
NFKB1 8527.0 5403.0
NFKB2 5450.0 -6553.0
NFKBIA 8114.0 5809.0
NHLRC1 -7039.0 -618.0
NLRP3 9713.0 9646.0
NMT1 4695.0 7205.0
NMT2 -7414.0 -10461.0
NOTCH1 -6741.0 1205.0
NOTCH2 1164.0 5400.0
NOTCH3 -7507.0 10318.0
NOTCH4 -10239.0 2947.0
NOXA1 -240.0 -6607.0
NPM1 4725.0 -8730.0
NR3C1 -4556.0 1036.0
NR4A1 -8998.0 -8557.0
NRAS 8582.0 7708.0
NRG1 7105.0 -2454.0
NRG4 4405.0 4.0
NT5E -7266.0 -9054.0
NTHL1 -8201.0 -7462.0
NUP107 -8816.0 -8274.0
NUP133 -5348.0 776.0
NUP153 -6945.0 -3734.0
NUP155 -5317.0 -7756.0
NUP160 -2219.0 -8347.0
NUP188 -9248.0 -9221.0
NUP205 -7213.0 -7389.0
NUP210 -10535.0 -6252.0
NUP214 8257.0 8111.0
NUP35 -4124.0 -8851.0
NUP37 5728.0 6078.0
NUP42 2461.0 -1423.0
NUP43 -3773.0 -8208.0
NUP50 6620.0 2938.0
NUP54 6985.0 -5266.0
NUP58 9614.0 9817.0
NUP62 6407.0 -2545.0
NUP85 2286.0 -2781.0
NUP88 -8115.0 -8802.0
NUP93 -5242.0 -7982.0
NUP98 -1200.0 2149.0
NUS1 9633.0 9296.0
OGG1 -6261.0 -6305.0
OPLAH 10311.0 10231.0
OS9 9572.0 10053.0
P2RX4 9476.0 9713.0
P2RX7 7506.0 2020.0
P2RY11 -8087.0 -9630.0
PABPN1 -4072.0 3194.0
PACS1 -9747.0 -9283.0
PAK2 9098.0 8874.0
PAPSS1 9496.0 10017.0
PAPSS2 -10395.0 3684.0
PARP1 -10265.0 -8043.0
PARP10 -8017.0 -9107.0
PARP14 -7760.0 -10413.0
PARP16 -10098.0 -10629.0
PARP4 -357.0 8142.0
PARP6 -3190.0 -1716.0
PARP8 -5883.0 -9490.0
PARP9 6037.0 -5670.0
PC 8077.0 10378.0
PCCA -5364.0 -5495.0
PCCB -8367.0 -5614.0
PDCD1 -7335.0 -8133.0
PDCD6IP 8622.0 9034.0
PDGFA 1176.0 5657.0
PDGFB -8368.0 -7863.0
PDGFRA -825.0 7909.0
PDGFRB -10542.0 -8788.0
PDPK1 -54.0 8056.0
PDZD3 -3667.0 -2126.0
PEBP1 -3719.0 -9443.0
PGK1 10177.0 9226.0
PGM1 2601.0 6092.0
PHB 4244.0 -2118.0
PHF21A 8929.0 10510.0
PIK3AP1 7061.0 8941.0
PIK3C3 4588.0 3248.0
PIK3CA 5168.0 6821.0
PIK3CB 9880.0 9707.0
PIK3CD -932.0 3422.0
PIK3R1 -7314.0 -9108.0
PIK3R2 2369.0 6022.0
PIK3R3 -10971.0 -7175.0
PIK3R4 -624.0 -83.0
PLCG1 -5836.0 -10187.0
PLCG2 -6227.0 6708.0
PLK2 -6787.0 -1782.0
PML -917.0 -9991.0
PMM2 8358.0 -635.0
PMS2 304.0 2030.0
POLR2A -9475.0 -260.0
POLR2B 296.0 2423.0
POLR2C 3736.0 -612.0
POLR2D 6248.0 -1802.0
POLR2E 8013.0 8218.0
POLR2F 320.0 5451.0
POLR2G 1642.0 5704.0
POLR2H 4812.0 -2703.0
POLR2I 2083.0 1475.0
POLR2J 7302.0 8189.0
POLR2K 7511.0 2990.0
POLR2L 2955.0 6234.0
POM121 -9318.0 -4714.0
POM121C -10088.0 -6969.0
POMC 2426.0 -2728.0
POMGNT1 -8871.0 -8356.0
POMT1 -2490.0 -6701.0
POMT2 -2061.0 5039.0
PORCN -8837.0 -7524.0
PPIA 285.0 1417.0
PPP1CB 8424.0 7913.0
PPP1CC 9534.0 8032.0
PPP2CA 9766.0 8577.0
PPP2CB 9136.0 9093.0
PPP2R1A 1997.0 5379.0
PPP2R1B 3691.0 1706.0
PPP2R5A -3440.0 4169.0
PPP2R5B 4569.0 7252.0
PPP2R5C -9892.0 -8496.0
PPP2R5D -5620.0 3209.0
PPP2R5E 522.0 2302.0
PRDX1 9223.0 7690.0
PRDX2 8560.0 1885.0
PRELP 3410.0 1496.0
PRKACA 9995.0 10558.0
PRKACB -8479.0 -10448.0
PRKAR1A 8904.0 9754.0
PRKAR1B 7778.0 8646.0
PRKAR2A 1151.0 7558.0
PRKAR2B 4069.0 6461.0
PRKCSH 1054.0 6027.0
PRKX -4033.0 -8552.0
PRR5 -10901.0 -10359.0
PSEN1 7406.0 9055.0
PSEN2 -2616.0 -7755.0
PSENEN 8280.0 7751.0
PSIP1 906.0 -8217.0
PSMA1 9165.0 8953.0
PSMA2 9175.0 6486.0
PSMA3 8811.0 -3545.0
PSMA4 8595.0 258.0
PSMA5 6009.0 -5256.0
PSMA6 9365.0 6915.0
PSMA7 6006.0 7700.0
PSMB1 8548.0 3242.0
PSMB10 -972.0 -8733.0
PSMB2 8065.0 5797.0
PSMB3 8817.0 8326.0
PSMB4 4018.0 3039.0
PSMB5 8225.0 9508.0
PSMB6 6959.0 8991.0
PSMB7 9346.0 8950.0
PSMB8 5148.0 -5793.0
PSMB9 -5133.0 -10716.0
PSMC1 7220.0 8544.0
PSMC2 4967.0 6378.0
PSMC3 2824.0 4673.0
PSMC4 -9365.0 -3210.0
PSMC5 2913.0 2050.0
PSMC6 9832.0 7978.0
PSMD1 8509.0 8974.0
PSMD10 6347.0 2957.0
PSMD11 8697.0 9183.0
PSMD12 9648.0 8351.0
PSMD13 7185.0 6511.0
PSMD14 7985.0 5632.0
PSMD2 7347.0 8049.0
PSMD3 3057.0 6067.0
PSMD4 8627.0 9334.0
PSMD5 1520.0 8328.0
PSMD6 9864.0 9375.0
PSMD7 9212.0 6772.0
PSMD8 6905.0 6585.0
PSMD9 7407.0 8869.0
PSME1 -1137.0 -9489.0
PSME2 3614.0 -10267.0
PSME3 9544.0 8452.0
PSME4 -8419.0 -464.0
PSMF1 7685.0 5740.0
PSTPIP1 635.0 9877.0
PTEN 8668.0 9329.0
PTGDR -11008.0 -10143.0
PTGER2 4914.0 -851.0
PTGER4 -10396.0 -9272.0
PTGES3 9517.0 4303.0
PTGIR -5450.0 -8455.0
PTK2 4992.0 3213.0
PTPN11 3471.0 9688.0
PTPN12 6377.0 9874.0
PYCARD 8846.0 9930.0
QKI 9569.0 10397.0
RAB5A 9230.0 7808.0
RAB7A 9941.0 9609.0
RAC1 9345.0 9946.0
RAC2 -1305.0 4460.0
RAE1 7170.0 7531.0
RAF1 8083.0 7846.0
RAMP1 -10861.0 -4789.0
RAN 4957.0 -2873.0
RANBP1 1212.0 -5657.0
RANBP2 457.0 512.0
RANGAP1 -9450.0 -10158.0
RAP1A 9691.0 8186.0
RAP1B -3254.0 7324.0
RB1 10070.0 10186.0
RBBP4 4490.0 4905.0
RBBP7 -9908.0 -7503.0
RBPJ 9553.0 10058.0
RBX1 1119.0 4750.0
RCC1 -7597.0 681.0
RCOR1 9761.0 9880.0
RDH5 8386.0 1337.0
RELA -2847.0 -1359.0
REST -3978.0 3460.0
RFT1 6431.0 989.0
RHBDF2 -3923.0 7165.0
RHOG 8649.0 8946.0
RICTOR -7204.0 -8306.0
RIPK1 -8110.0 -7415.0
RLN2 -596.0 -6146.0
RLN3 -4997.0 8709.0
RNF185 6388.0 8065.0
RNF213 -10507.0 -10252.0
RNF43 -9954.0 -10713.0
RNF5 -7305.0 -918.0
RNGTT 5056.0 5997.0
RNMT -5125.0 -8418.0
ROCK1 5871.0 8890.0
ROCK2 2896.0 8362.0
RPIA 5489.0 -714.0
RPL10 631.0 -5696.0
RPL10A 1976.0 -6292.0
RPL11 1839.0 -3327.0
RPL12 2014.0 -5298.0
RPL13 2796.0 -3228.0
RPL13A -1728.0 -6706.0
RPL14 -1317.0 -5766.0
RPL15 5748.0 532.0
RPL17 143.0 -3476.0
RPL18 3381.0 -4456.0
RPL18A -1706.0 -4694.0
RPL19 -787.0 -4539.0
RPL21 276.0 -3918.0
RPL22 4761.0 -1687.0
RPL22L1 7231.0 -349.0
RPL23 3153.0 -1612.0
RPL23A -903.0 -7885.0
RPL24 1656.0 -1751.0
RPL26 842.0 -3483.0
RPL26L1 8258.0 7992.0
RPL27 1376.0 -417.0
RPL27A -1685.0 -3049.0
RPL28 2709.0 -1855.0
RPL29 1515.0 -3475.0
RPL3 -3958.0 -7454.0
RPL30 -2576.0 -5578.0
RPL31 -429.0 -3242.0
RPL32 219.0 -4702.0
RPL34 -1732.0 -6642.0
RPL35 -9119.0 -4134.0
RPL35A -112.0 -2513.0
RPL36 -4022.0 -4235.0
RPL36A 1606.0 -4363.0
RPL36AL 5944.0 -2052.0
RPL37 -6271.0 -3029.0
RPL37A -2362.0 -447.0
RPL38 -4515.0 -3500.0
RPL39 2137.0 350.0
RPL39L -7572.0 -3974.0
RPL4 4738.0 -2403.0
RPL41 -1299.0 -3511.0
RPL5 4105.0 -2796.0
RPL6 4935.0 -1237.0
RPL7 5143.0 -1272.0
RPL7A 1809.0 -1927.0
RPL8 1265.0 -1924.0
RPL9 700.0 -4879.0
RPLP0 6333.0 -1009.0
RPLP1 -1197.0 916.0
RPLP2 -4847.0 -5802.0
RPN1 8456.0 8842.0
RPN2 7659.0 7805.0
RPS10 -489.0 -4974.0
RPS11 -2316.0 -5641.0
RPS12 -4797.0 -7620.0
RPS13 5276.0 -1635.0
RPS14 -4624.0 -5393.0
RPS15 -1754.0 -3299.0
RPS15A 1269.0 -4048.0
RPS16 -2078.0 -6063.0
RPS17 -5045.0 -3169.0
RPS18 -7322.0 -6605.0
RPS19 -2989.0 -7057.0
RPS2 1634.0 -3308.0
RPS20 -2911.0 -6018.0
RPS21 -1933.0 -3896.0
RPS23 772.0 -4150.0
RPS24 6586.0 1001.0
RPS25 2600.0 -3817.0
RPS26 3527.0 -5041.0
RPS27 -7168.0 -6878.0
RPS27A -1868.0 -5386.0
RPS27L 7604.0 4230.0
RPS28 -2921.0 -3626.0
RPS29 -6817.0 -4617.0
RPS3 2486.0 -5123.0
RPS3A 5865.0 -3619.0
RPS4X -677.0 -7632.0
RPS4Y1 3815.0 574.0
RPS5 -1017.0 -5500.0
RPS6 2176.0 -3737.0
RPS6KB2 1743.0 379.0
RPS7 1946.0 -2271.0
RPS8 3760.0 -769.0
RPS9 7673.0 4928.0
RPSA -3597.0 -5016.0
RXFP2 8774.0 9074.0
S1PR1 -10247.0 -7325.0
SAP18 8251.0 6907.0
SAP30 6723.0 9651.0
SAP30L -3717.0 5841.0
SBSPON -4934.0 -2575.0
SCT -9440.0 -8419.0
SDC2 6034.0 5778.0
SDC3 8050.0 -2699.0
SDC4 7546.0 7624.0
SEC13 6324.0 5321.0
SEH1L 8372.0 -4799.0
SEL1L 6263.0 8390.0
SEM1 5210.0 6938.0
SEMA5A -4342.0 -5873.0
SEMA5B -3073.0 5550.0
SERPING1 533.0 -10700.0
SFPQ 6274.0 2084.0
SFTPB 5533.0 5216.0
SFTPD -10946.0 -8018.0
SGSH 4711.0 5490.0
SH3GL1 6353.0 8238.0
SH3KBP1 2654.0 6905.0
SHC1 3101.0 5292.0
SHOC2 7882.0 8016.0
SIGMAR1 -4018.0 -6358.0
SIN3A -8565.0 -8326.0
SKP1 8911.0 4204.0
SKP2 -4203.0 -2704.0
SLC11A2 7073.0 3742.0
SLC12A1 6035.0 -2475.0
SLC12A3 -10024.0 -4872.0
SLC12A6 4854.0 9333.0
SLC16A1 5760.0 3184.0
SLC17A5 5214.0 7726.0
SLC1A3 10174.0 10371.0
SLC20A2 -10715.0 -5064.0
SLC22A18 -1932.0 7440.0
SLC22A5 8103.0 9235.0
SLC24A1 -8756.0 -3911.0
SLC24A4 8543.0 7730.0
SLC25A4 -8141.0 -9466.0
SLC25A5 1563.0 2136.0
SLC25A6 2878.0 3468.0
SLC26A2 -4754.0 3163.0
SLC27A4 -5238.0 2577.0
SLC29A3 3085.0 6245.0
SLC2A1 -10701.0 -8961.0
SLC2A10 -5947.0 -2541.0
SLC2A9 8739.0 3153.0
SLC33A1 3665.0 1419.0
SLC34A1 -168.0 -2660.0
SLC34A2 4161.0 -3802.0
SLC34A3 -5949.0 -5935.0
SLC35A1 9584.0 8867.0
SLC35A2 -5935.0 1912.0
SLC35A3 956.0 -5401.0
SLC35C1 -420.0 442.0
SLC35D1 -9609.0 -1243.0
SLC36A2 -6264.0 -1061.0
SLC37A4 -7007.0 -3274.0
SLC39A4 4288.0 3277.0
SLC3A1 -8138.0 -4735.0
SLC3A2 3731.0 6261.0
SLC40A1 9619.0 5856.0
SLC4A1 9896.0 9193.0
SLC4A4 -10859.0 -8817.0
SLC5A2 2043.0 -6862.0
SLC5A5 4332.0 -7342.0
SLC6A20 -7757.0 -1119.0
SLC7A7 7011.0 8916.0
SLC9A6 2791.0 6385.0
SLC9A9 7467.0 9719.0
SMAD2 1682.0 7725.0
SMAD3 -10166.0 -9199.0
SMAD4 -3390.0 -7669.0
SND1 2625.0 5664.0
SNF8 6092.0 7999.0
SNW1 8504.0 6624.0
SOD2 9488.0 2250.0
SOS1 2394.0 -4661.0
SPON1 -5995.0 -7498.0
SPON2 -10960.0 -9851.0
SPRED1 -8378.0 -3713.0
SPRED2 -2639.0 8478.0
SPRED3 -3150.0 -3741.0
SRC -4936.0 -8846.0
SRD5A3 7881.0 1403.0
SSRP1 -7860.0 -7144.0
ST3GAL1 -7981.0 -6569.0
ST3GAL2 7602.0 9502.0
ST3GAL3 -1028.0 2393.0
ST3GAL4 -9447.0 4972.0
ST6GAL1 -10455.0 -8619.0
ST6GALNAC2 6173.0 3933.0
ST6GALNAC3 7932.0 10316.0
ST6GALNAC4 -8293.0 105.0
STAM 2880.0 1495.0
STAM2 8313.0 7133.0
STAT1 -3982.0 -10718.0
STAT2 -2902.0 -9912.0
STAT3 9401.0 8593.0
STAT5A 8323.0 7832.0
STAT5B 4680.0 4956.0
STRN -4503.0 6601.0
STT3A 6910.0 6477.0
STX1A -8692.0 -2626.0
STX1B 3620.0 -3757.0
SUDS3 3710.0 6309.0
SUGT1 4885.0 5013.0
SUMO1 9138.0 8090.0
SUPT16H -7108.0 -9158.0
SUPT4H1 1936.0 2459.0
SUPT5H -6280.0 -3833.0
SUZ12 4242.0 493.0
SV2A -8210.0 -9881.0
SV2B 1790.0 2761.0
SV2C 1043.0 -3997.0
SYK 9750.0 10350.0
SYT1 7846.0 6678.0
SYT2 -7268.0 -5231.0
SYVN1 25.0 3387.0
TAF1 -9470.0 -2762.0
TAF10 4355.0 8862.0
TAF11 7134.0 5072.0
TAF12 8338.0 8905.0
TAF13 8231.0 8380.0
TAF15 -3261.0 -2561.0
TAF2 -3927.0 441.0
TAF3 2390.0 -1468.0
TAF4 -9722.0 -589.0
TAF4B -1360.0 -6245.0
TAF5 -4709.0 -3446.0
TAF6 -8405.0 -3954.0
TAF7 -106.0 631.0
TAF9 9334.0 233.0
TAF9B 7166.0 -3686.0
TALDO1 10319.0 10395.0
TBK1 8071.0 5122.0
TBL1X 6931.0 7717.0
TBL1XR1 5299.0 5430.0
TBP -307.0 -4592.0
TBXAS1 8240.0 10114.0
TCEA1 5679.0 1886.0
TCF7L2 -10234.0 -870.0
TCN2 9870.0 9929.0
TENT4A -6795.0 -9444.0
TFDP1 9979.0 8001.0
TFDP2 -10993.0 -10675.0
TGFA 5895.0 9650.0
TGFB1 984.0 3574.0
TGFBR1 -7710.0 -1431.0
TGFBR2 -6958.0 4321.0
THBS1 1255.0 9820.0
THSD1 5465.0 -5825.0
THSD4 -5193.0 -420.0
THSD7A -8644.0 -8243.0
TICAM1 6577.0 5314.0
TIRAP -8.0 6185.0
TLN1 5974.0 9916.0
TLR1 10059.0 9241.0
TLR10 -4242.0 -4361.0
TLR2 10239.0 9881.0
TLR3 -9392.0 -9897.0
TLR4 9286.0 10255.0
TLR5 9706.0 9984.0
TLR6 9187.0 9277.0
TLR7 9073.0 -6333.0
TLR9 -10559.0 -4710.0
TNKS -8859.0 -2898.0
TNKS2 642.0 4031.0
TPMT 7839.0 6563.0
TPR -4478.0 -7012.0
TPST1 2152.0 10253.0
TPST2 -8642.0 6809.0
TRADD 7677.0 -7288.0
TRAF2 -7822.0 -10338.0
TRAF3 3014.0 -4910.0
TRAK1 -6177.0 7753.0
TRAT1 6974.0 -9441.0
TRIM24 5480.0 1900.0
TRIM27 9100.0 8140.0
TRIM28 -6726.0 -6061.0
TSC2 -2640.0 -1107.0
TSG101 9865.0 7776.0
TSHR 4971.0 -932.0
TUBB -6747.0 -3278.0
TXN 9660.0 8103.0
TXNIP -7875.0 -4331.0
TXNRD1 8785.0 8833.0
TYK2 4043.0 8696.0
UBA52 2067.0 260.0
UBAP1 9245.0 9187.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2C 5494.0 3509.0
UBE2D1 10262.0 10093.0
UBE2E1 9885.0 8679.0
UBE2I -1027.0 5239.0
UBE2S 6887.0 3531.0
UGT1A1 -4863.0 2251.0
UNC93B1 42.0 5485.0
UVRAG -919.0 -4257.0
VAMP1 -3673.0 -7729.0
VAMP2 -4429.0 -10264.0
VAV1 6299.0 7892.0
VAV2 -9043.0 2054.0
VAV3 -7486.0 7780.0
VCAN 10280.0 10667.0
VCL 913.0 8321.0
VCP 7591.0 6702.0
VEGFA 7943.0 7054.0
VHL -700.0 5272.0
VIPR1 -1716.0 -3811.0
VIPR2 -10941.0 -9130.0
VPS25 8588.0 9314.0
VPS28 5467.0 4829.0
VPS33B -5085.0 6951.0
VPS36 3782.0 -1712.0
VPS37A 8256.0 7697.0
VPS37B -9060.0 3262.0
VPS37C 9329.0 8849.0
VPS4A 330.0 3807.0
VPS4B 6755.0 6176.0
VTA1 8205.0 7811.0
VWF 3995.0 7559.0
WAS 9521.0 9854.0
WASF1 10267.0 10673.0
WASF2 6329.0 9933.0
WASF3 5357.0 6353.0
WASL -3272.0 1473.0
WDR48 -6698.0 -8483.0
WIPF1 -7238.0 -2901.0
WIPF2 1332.0 7562.0
XPO1 7772.0 4672.0
XRCC4 8532.0 8109.0
XRCC5 7806.0 6087.0
XRCC6 6022.0 -236.0
YES1 -10892.0 -9337.0
YWHAB 9116.0 6191.0
YWHAE 10079.0 10158.0
ZBP1 -10466.0 -10697.0
ZC3HAV1 -3544.0 -9557.0
ZCRB1 6828.0 4542.0
ZFYVE9 -5444.0 -6753.0
ZMYM2 5653.0 7881.0



Toll-like Receptor Cascades

Toll-like Receptor Cascades
metric value
setSize 143
pMANOVA 3.96e-14
p.adjustMANOVA 1.32e-12
s.dist 0.479
s.low.CRP 0.322
s.high.CRP 0.354
p.low.CRP 2.73e-11
p.high.CRP 2.48e-13




Top 20 genes
Gene low CRP high CRP
S100A12 10367 10617
S100A8 10362 10564
S100A9 10316 10598
CD36 10363 10493
TLR8 10249 10439
DUSP3 10238 10410
ITGAM 10114 10483
CTSB 9828 10631
CD14 10063 10306
UBE2D1 10262 10093
TLR2 10239 9881
APP 10085 9961
NKIRAS2 9577 10434
IRAK3 9582 10412
MAPK14 10026 9803
ITGB2 9132 10614
TLR5 9706 9984
TLR4 9286 10255
MAPK3 9769 9676
LY86 9998 9324

Click HERE to show all gene set members

All member genes
low CRP high CRP
AGER 1815 2573
APP 10085 9961
ATF1 9088 8764
ATF2 8316 2303
BIRC2 8116 2944
BIRC3 2030 -10298
BPI 9742 5505
BTK 5823 9633
BTRC -7062 1812
CASP8 -9202 -9212
CD14 10063 10306
CD180 -1342 -678
CD36 10363 10493
CHUK 9608 9191
CNPY3 7051 7961
CREB1 2938 -595
CTSB 9828 10631
CTSK 7599 3855
CTSL -5492 6157
CTSS 10120 8325
CTSV 3692 -1862
CUL1 7475 -10175
DNM1 5661 -1028
DNM2 -2349 6839
DNM3 1942 8165
DUSP3 10238 10410
DUSP4 -3900 -8336
DUSP6 7156 -2241
DUSP7 -5905 -3113
ECSIT 5443 4562
EEA1 6276 7915
ELK1 5371 2922
FADD -3902 4370
FBXW11 3233 8725
FOS 7518 2641
HMGB1 3409 1050
HSP90B1 8375 1593
IKBKB -6356 -1160
IKBKE 3422 7754
IKBKG -595 7203
IRAK1 2858 6473
IRAK2 -10838 -5931
IRAK3 9582 10412
IRF3 -453 -6404
IRF7 -7026 -8410
ITGAM 10114 10483
ITGB2 9132 10614
JUN 481 -1015
LGMN -2173 -1771
LY86 9998 9324
LY96 9677 9581
MAP2K1 8861 10365
MAP2K3 8777 8502
MAP2K4 5525 7430
MAP2K6 8704 10103
MAP2K7 -1568 2972
MAP3K1 380 8292
MAP3K7 2469 7237
MAP3K8 -7148 10028
MAPK1 -1086 9427
MAPK10 6946 6199
MAPK11 8895 6888
MAPK14 10026 9803
MAPK3 9769 9676
MAPK7 -9798 3379
MAPK8 -794 -7374
MAPK9 -6911 1519
MAPKAPK2 -10648 4888
MAPKAPK3 7908 10021
MEF2A 8559 9073
MEF2C 5395 -197
MYD88 8926 8524
NFKB1 8527 5403
NFKB2 5450 -6553
NFKBIA 8114 5809
NFKBIB -5904 1139
NKIRAS1 1465 2281
NKIRAS2 9577 10434
NOD1 -10556 -9537
NOD2 9289 9320
PELI1 8918 5667
PELI2 7349 9515
PELI3 -320 9317
PIK3C3 4588 3248
PIK3R4 -624 -83
PLCG2 -6227 6708
PPP2CA 9766 8577
PPP2CB 9136 9093
PPP2R1A 1997 5379
PPP2R1B 3691 1706
PPP2R5D -5620 3209
PTPN11 3471 9688
PTPN4 -10744 -10485
RBSN -8580 -3332
RELA -2847 -1359
RIPK1 -8110 -7415
RIPK2 8675 2009
RIPK3 -2562 6478
RPS27A -1868 -5386
RPS6KA1 1245 8996
RPS6KA2 -5842 2331
RPS6KA3 1034 3942
RPS6KA5 70 -10393
S100A1 -2763 -3665
S100A12 10367 10617
S100A8 10362 10564
S100A9 10316 10598
S100B -10129 814
SARM1 -9903 -10510
SIGIRR -8187 -8512
SKP1 8911 4204
SOCS1 8467 6659
TAB1 7080 3716
TAB2 8556 6836
TAB3 215 4794
TANK 9785 8152
TBK1 8071 5122
TICAM1 6577 5314
TICAM2 9445 5256
TIRAP -8 6185
TLR1 10059 9241
TLR10 -4242 -4361
TLR2 10239 9881
TLR3 -9392 -9897
TLR4 9286 10255
TLR5 9706 9984
TLR6 9187 9277
TLR7 9073 -6333
TLR8 10249 10439
TLR9 -10559 -4710
TNIP2 -929 4907
TRAF3 3014 -4910
TRAF6 -4471 1582
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UBE2D1 10262 10093
UBE2D2 5413 5174
UBE2D3 9631 8934
UBE2N 7813 4195
UBE2V1 8249 8108
UNC93B1 42 5485
VRK3 -2450 3426



Transport to the Golgi and subsequent modification

Transport to the Golgi and subsequent modification
metric value
setSize 155
pMANOVA 7.81e-14
p.adjustMANOVA 2.53e-12
s.dist 0.424
s.low.CRP 0.223
s.high.CRP 0.361
p.low.CRP 1.74e-06
p.high.CRP 8.01e-15




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
SERPINA1 10186 10295
ARF4 10147 10254
CTSZ 9796 10451
KDELR1 9879 10352
RAB1A 10223 9909
CD55 9747 10312
DCTN2 9097 10370
FUCA1 9326 10044
ARF1 9085 10196
B4GALT5 9525 9637
DCTN6 9751 9405
CAPZA2 10077 9039
NSF 8767 10358
TMED7 9644 9106
CAPZA1 9332 9316
SPTB 9406 9121
COPG2 8584 9972
ACTR10 9447 8995
COPB2 9499 8940

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACTR10 9447 8995
ACTR1A 1291 7735
ANK1 9056 9344
ANK3 5423 -4595
ANKRD28 -8321 -2586
ARCN1 4291 7676
AREG -5505 9162
ARF1 9085 10196
ARF3 7124 9257
ARF4 10147 10254
ARF5 8080 9476
ARFGAP1 -2066 -296
ARFGAP2 -7117 -3644
ARFGAP3 2322 4136
B4GALT1 -3872 6820
B4GALT2 -2272 31
B4GALT3 -7395 -8398
B4GALT4 -6517 3566
B4GALT5 9525 9637
B4GALT6 -10803 131
BET1 6957 1985
BET1L -4965 -5604
CAPZA1 9332 9316
CAPZA2 10077 9039
CAPZB 8393 8843
CD55 9747 10312
CD59 6386 4199
CHST10 -10642 -7986
CHST8 189 6510
CNIH1 9266 8825
CNIH2 2506 2667
CNIH3 -9428 -8506
COG1 -9533 -9241
COG2 3963 1728
COG3 3114 -4075
COG4 -3232 889
COG5 3937 3634
COG6 1615 -87
COG7 7042 7599
COG8 -5751 -901
COL7A1 -442 8394
COPA 6851 10178
COPB1 9548 8670
COPB2 9499 8940
COPE 5686 8054
COPG1 7245 9390
COPG2 8584 9972
COPZ1 8315 6558
COPZ2 -2992 -9775
CSNK1D -8768 1189
CTSC -3910 5638
CTSZ 9796 10451
DCTN1 -4701 7431
DCTN2 9097 10370
DCTN3 3675 7530
DCTN4 5909 10148
DCTN5 -6881 5731
DCTN6 9751 9405
DYNC1H1 -9811 -4718
DYNC1I1 378 6338
DYNC1I2 8978 9397
DYNC1LI1 8227 7194
DYNC1LI2 909 7271
DYNLL1 6414 7208
DYNLL2 -5827 -2261
F5 10339 10599
F8 7904 8494
FUCA1 9326 10044
FUT8 -9860 -5220
GBF1 -8195 348
GOLGA2 -6652 7914
GOLGB1 -5170 -2548
GORASP1 8524 6879
GOSR1 -5651 3364
GOSR2 -1757 3596
KDELR1 9879 10352
KDELR2 9893 7875
KDELR3 -1354 -6629
LMAN1 -2101 -9736
LMAN2 6893 7688
LMAN2L 7489 7830
MAN1A1 6497 9657
MAN1A2 -6602 1179
MAN1C1 1396 -8830
MAN2A1 1336 -1270
MAN2A2 -4209 7794
MANEA 7385 -2869
MCFD2 7974 9249
MGAT1 362 7982
MGAT2 -3625 2214
MGAT3 174 -9979
MGAT4A -482 -6981
MGAT4B 9034 9077
MGAT4C 1409 -1128
MGAT5 -8963 1454
MIA2 6400 5836
MIA3 40 -2504
NAPA 4940 2147
NAPB -4472 1066
NAPG 5219 7040
NSF 8767 10358
PPP6C 9263 7953
PPP6R1 -4291 7176
PPP6R3 1461 4805
PREB 4312 7535
RAB1A 10223 9909
RAB1B 8291 9474
SAR1B 9412 8914
SCFD1 6826 7619
SEC13 6324 5321
SEC16A -6613 6860
SEC16B -340 3720
SEC22A 5519 1741
SEC22B 9017 4952
SEC22C 2177 1557
SEC23A 8250 8136
SEC23IP 6616 2151
SEC24A 8608 8866
SEC24B 280 5708
SEC24C -8540 1964
SEC24D 8466 9932
SEC31A 1943 6528
SERPINA1 10186 10295
SPTA1 9220 7274
SPTAN1 -10045 -9563
SPTB 9406 9121
SPTBN1 -8781 -6351
SPTBN2 -6201 -2780
SPTBN5 -7032 -3485
ST3GAL4 -9447 4972
ST6GAL1 -10455 -8619
ST8SIA6 -10591 -7843
STX17 -2656 -9125
STX5 6777 7536
TBC1D20 -5268 1442
TFG 9720 8105
TGFA 5895 9650
TMED10 4984 4383
TMED2 6691 7410
TMED3 3770 4652
TMED7 9644 9106
TMED9 7191 9462
TMEM115 3217 3929
TRAPPC1 6932 9117
TRAPPC10 -10367 -4001
TRAPPC2 -9388 -4103
TRAPPC2L 4084 340
TRAPPC3 8513 8500
TRAPPC4 -6015 -5250
TRAPPC5 -685 471
TRAPPC6A -1341 -9288
TRAPPC6B 6911 6051
TRAPPC9 3787 8190
USO1 8607 7741
YKT6 1766 6226



FCGR3A-mediated IL10 synthesis

FCGR3A-mediated IL10 synthesis
metric value
setSize 98
pMANOVA 8.68e-14
p.adjustMANOVA 2.75e-12
s.dist 0.334
s.low.CRP 0.0521
s.high.CRP -0.33
p.low.CRP 0.372
p.high.CRP 1.69e-08




Top 20 genes
Gene low CRP high CRP
IGHV3-30 6205 -8897
IGKV1-5 5340 -9482
IGLV5-45 5252 -9604
IGHV3-11 6603 -6880
IGKV1-12 4565 -9660
IGLV2-8 4817 -8917
IGLV7-46 6144 -6715
IGKV3-11 4335 -8929
IGHV3-23 5184 -7276
IGKV1-33 5570 -6751
IGLV6-57 4672 -7639
IGKV4-1 5759 -5700
IGKC 3871 -8235
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV1-17 5659 -4913
IGLV2-23 4476 -5875
IGKV5-2 3670 -6960
IGKV1-16 4776 -5235
IGLV1-44 3169 -7580

Click HERE to show all gene set members

All member genes
low CRP high CRP
ADCY2 -3835 2899
ADCY3 9752 10224
ADCY4 4464 2329
ADCY5 -10012 -4366
ADCY6 -5852 -3739
ADCY7 -9455 -1458
ADCY9 -8919 1933
AHCYL1 4949 8470
CALM1 -4337 1051
CD247 -10994 -10515
CD3G -8283 -10568
CREB1 2938 -595
FCGR1A 10365 10249
FCGR2A 9647 9000
FCGR3A -11031 -7169
FGR 7776 10127
FYN -10683 -7016
HCK 10073 9850
IGHG1 -3727 -9610
IGHG2 -2988 -6697
IGHG3 3688 -4504
IGHG4 -6480 -3573
IGHV1-2 7949 -2404
IGHV1-46 1645 -7097
IGHV1-69 -473 -3585
IGHV2-5 -761 -7784
IGHV2-70 -5110 -2783
IGHV3-11 6603 -6880
IGHV3-13 -4367 -5652
IGHV3-23 5184 -7276
IGHV3-30 6205 -8897
IGHV3-33 -1859 -6548
IGHV3-48 1158 -4630
IGHV3-53 439 -4325
IGHV3-7 2687 -5396
IGHV4-34 -3831 -5446
IGHV4-39 -3715 -8660
IGHV4-59 1427 -4638
IGKC 3871 -8235
IGKV1-12 4565 -9660
IGKV1-16 4776 -5235
IGKV1-17 5659 -4913
IGKV1-33 5570 -6751
IGKV1-5 5340 -9482
IGKV1D-39 2361 -3975
IGKV2-28 600 -6240
IGKV2-30 2124 -5952
IGKV2D-28 -8241 -7171
IGKV3-11 4335 -8929
IGKV3-15 3182 -9110
IGKV3-20 3477 -8253
IGKV3D-20 -604 -487
IGKV4-1 5759 -5700
IGKV5-2 3670 -6960
IGLC1 -2564 -7780
IGLC2 -3391 -9023
IGLC3 -211 -3454
IGLC7 -5718 -8734
IGLV1-36 -1581 -5381
IGLV1-40 -5815 -8593
IGLV1-44 3169 -7580
IGLV1-47 -657 -7558
IGLV1-51 -1719 -7074
IGLV10-54 3553 -6006
IGLV2-11 1826 -4201
IGLV2-14 -4545 -8212
IGLV2-18 5165 -4216
IGLV2-23 4476 -5875
IGLV2-8 4817 -8917
IGLV3-1 -5764 -8993
IGLV3-12 -6620 -5525
IGLV3-19 2884 -7478
IGLV3-21 -1967 -5619
IGLV3-25 -5461 -6576
IGLV3-27 -8634 -4435
IGLV4-69 -1909 -6359
IGLV5-45 5252 -9604
IGLV6-57 4672 -7639
IGLV7-43 165 2135
IGLV7-46 6144 -6715
IGLV8-61 3943 -3641
IL10 9226 10431
ITPR1 -9755 -3689
ITPR2 4786 9335
ITPR3 -8426 -7902
LYN 8483 8583
PLCG1 -5836 -10187
PLCG2 -6227 6708
PRKACA 9995 10558
PRKACB -8479 -10448
PRKAR1A 8904 9754
PRKAR1B 7778 8646
PRKAR2A 1151 7558
PRKAR2B 4069 6461
PRKX -4033 -8552
SRC -4936 -8846
SYK 9750 10350
YES1 -10892 -9337



Hemostasis

Hemostasis
metric value
setSize 542
pMANOVA 1.02e-13
p.adjustMANOVA 3.17e-12
s.dist 0.245
s.low.CRP 0.166
s.high.CRP 0.18
p.low.CRP 4.31e-11
p.high.CRP 6.88e-13




Top 20 genes
Gene low CRP high CRP
F5 10339 10599
SIRPA 10351 10576
F12 10253 10643
CD36 10363 10493
PLA2G4A 10226 10618
GNA15 10227 10612
SERPINB2 10291 10534
ITGAM 10114 10483
NFE2 10281 10299
GNG10 10307 10252
MAFG 10265 10293
PRKACA 9995 10558
CYB5R1 10052 10467
LHFPL2 9993 10508
SERPINA1 10186 10295
QSOX1 9888 10475
GRB2 9960 10389
APLP2 9754 10588
CD177 9884 10435
CD63 9814 10489

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 7201.0 6324.0
A2M -7493.0 -9192.0
AAMP -546.0 -3061.0
ABCC4 4731.0 8657.0
ABHD12 -10547.0 -6538.0
ABHD6 -8566.0 3459.0
ABL1 -8248.0 3812.0
ACTN1 9802.0 9301.0
ACTN4 -6751.0 7995.0
ADRA2A -4933.0 4150.0
AK3 4840.0 4079.0
AKAP1 -5118.0 -9867.0
AKAP10 5571.0 9170.0
AKT1 -5096.0 2421.0
ALB 5157.0 1598.0
ALDOA 10140.0 10121.0
ANGPT1 -2624.0 1229.0
ANGPT2 -1634.0 1400.0
ANGPT4 -9816.0 -2410.0
ANXA2 9791.0 10138.0
ANXA5 10047.0 9393.0
APBB1IP 10051.0 8873.0
APLP2 9754.0 10588.0
APOOL 6366.0 5539.0
APP 10085.0 9961.0
ARRB1 -5720.0 3058.0
ARRB2 8232.0 9058.0
ATP1B1 -8554.0 -5287.0
ATP1B2 6531.0 7889.0
ATP1B3 -1519.0 3938.0
ATP2A1 -4842.0 -734.0
ATP2A2 7987.0 8967.0
ATP2A3 -10436.0 -1355.0
ATP2B1 -3461.0 -5580.0
ATP2B4 -10562.0 922.0
BRPF3 -9645.0 -6135.0
BSG 9321.0 9898.0
C1QBP 6269.0 -1813.0
CABLES1 -10684.0 -5554.0
CABLES2 -5948.0 -3425.0
CALM1 -4337.0 1051.0
CALU 8618.0 9731.0
CAP1 9134.0 8626.0
CAPZA1 9332.0 9316.0
CAPZA2 10077.0 9039.0
CAPZB 8393.0 8843.0
CARMIL1 -775.0 976.0
CAV1 1798.0 -1413.0
CBX5 -5063.0 -7545.0
CD109 6898.0 6560.0
CD177 9884.0 10435.0
CD2 -8733.0 -10654.0
CD244 -8864.0 -4823.0
CD36 10363.0 10493.0
CD44 9109.0 9660.0
CD47 -8631.0 -9598.0
CD48 5691.0 2513.0
CD58 8027.0 7845.0
CD63 9814.0 10489.0
CD74 -7667.0 -10115.0
CD84 -1440.0 7744.0
CD9 7795.0 5893.0
CD99 4318.0 9773.0
CD99L2 7533.0 10110.0
CDC37L1 1694.0 -5736.0
CDC42 9246.0 8570.0
CDK2 -3816.0 1587.0
CDK5 9150.0 10447.0
CEACAM1 8525.0 8200.0
CEACAM3 5874.0 4896.0
CEACAM6 9295.0 4203.0
CEACAM8 9490.0 3624.0
CENPE -3770.0 492.0
CFD 911.0 -342.0
CFL1 9368.0 9341.0
CHID1 1491.0 3495.0
CLEC1B 9634.0 9849.0
CLEC3B 8957.0 10039.0
CLU 8797.0 10607.0
CRK 9214.0 9663.0
CSK -2015.0 6501.0
CTSW -10450.0 -9076.0
CYB5R1 10052.0 10467.0
DAGLA -9795.0 -7353.0
DAGLB -390.0 9293.0
DGKA 1996.0 -8807.0
DGKD -10564.0 796.0
DGKE -5951.0 -9294.0
DGKG 9117.0 9128.0
DGKH -1070.0 -250.0
DGKK -9484.0 -7897.0
DGKQ -9702.0 -6805.0
DGKZ -8776.0 -6149.0
DOCK1 2337.0 9856.0
DOCK10 -4267.0 -8027.0
DOCK11 -1742.0 6408.0
DOCK2 3702.0 9336.0
DOCK3 3341.0 -6755.0
DOCK4 6944.0 8591.0
DOCK5 2752.0 9330.0
DOCK6 -5261.0 1631.0
DOCK7 -2076.0 -2321.0
DOCK8 4755.0 6910.0
DOCK9 -4445.0 -10363.0
DOK2 -9078.0 -297.0
ECM1 8140.0 6368.0
EGF 8136.0 8196.0
EHD1 -3242.0 2171.0
EHD2 -1188.0 7062.0
EHD3 -4043.0 4603.0
ENDOD1 -3996.0 3892.0
ESAM 5754.0 7844.0
F11R 8810.0 7916.0
F12 10253.0 10643.0
F13A1 9500.0 8453.0
F2R -10475.0 -7685.0
F2RL2 -8189.0 1891.0
F2RL3 -5912.0 4363.0
F5 10339.0 10599.0
F8 7904.0 8494.0
FAM3C -5488.0 -5977.0
FCER1G 9338.0 9547.0
FERMT3 9665.0 10217.0
FGR 7776.0 10127.0
FLNA -8851.0 2557.0
FN1 9912.0 6648.0
FYN -10683.0 -7016.0
GAS6 9599.0 9997.0
GATA1 7500.0 9202.0
GATA2 -7715.0 -10206.0
GATA3 -8401.0 -10666.0
GATA6 -10749.0 -8672.0
GLG1 -6569.0 5838.0
GNA11 5927.0 -295.0
GNA12 3200.0 3712.0
GNA13 3919.0 6618.0
GNA15 10227.0 10612.0
GNAI1 5305.0 5103.0
GNAI2 8368.0 9095.0
GNAI3 9913.0 8209.0
GNAQ 10128.0 9401.0
GNAS 4056.0 6487.0
GNB1 7951.0 9297.0
GNB2 8365.0 8530.0
GNB3 9486.0 -8169.0
GNB4 9757.0 8191.0
GNB5 -762.0 -205.0
GNG10 10307.0 10252.0
GNG11 4608.0 5846.0
GNG2 -10288.0 -2836.0
GNG3 6662.0 1225.0
GNG4 -1513.0 -1627.0
GNG5 9805.0 9666.0
GNG7 -5188.0 -5336.0
GNG8 -5154.0 2284.0
GNGT2 -10923.0 -9575.0
GP1BA 982.0 6984.0
GP1BB 1443.0 8042.0
GP5 2423.0 -4169.0
GP6 1911.0 8115.0
GP9 5315.0 8099.0
GPC1 -7727.0 -2335.0
GRB14 -223.0 -7575.0
GRB2 9960.0 10389.0
GTPBP2 -3289.0 8058.0
GYPA 9155.0 8968.0
GYPB 9436.0 7959.0
GYPC 6406.0 4078.0
H3-3A 9562.0 8829.0
H3C15 182.5 4598.5
HABP4 -4596.0 -10369.0
HBB 9671.0 6093.0
HBD 10032.0 9258.0
HBG1 9803.0 6681.0
HBG2 9852.0 9364.0
HDAC1 -2168.0 4381.0
HDAC2 9181.0 5219.0
HGF 8952.0 9949.0
HMG20B -1431.0 5212.0
HRAS 2906.0 -3843.0
HSPA5 9415.0 6475.0
IGHA1 6020.0 -8527.0
IGHA2 3566.0 -2966.0
IGHM -323.0 -1745.0
IGHV1-2 7949.0 -2404.0
IGHV1-46 1645.0 -7097.0
IGHV1-69 -473.0 -3585.0
IGHV2-5 -761.0 -7784.0
IGHV2-70 -5110.0 -2783.0
IGHV3-11 6603.0 -6880.0
IGHV3-13 -4367.0 -5652.0
IGHV3-23 5184.0 -7276.0
IGHV3-30 6205.0 -8897.0
IGHV3-33 -1859.0 -6548.0
IGHV3-48 1158.0 -4630.0
IGHV3-53 439.0 -4325.0
IGHV3-7 2687.0 -5396.0
IGHV4-34 -3831.0 -5446.0
IGHV4-39 -3715.0 -8660.0
IGHV4-59 1427.0 -4638.0
IGKC 3871.0 -8235.0
IGKV1-12 4565.0 -9660.0
IGKV1-16 4776.0 -5235.0
IGKV1-17 5659.0 -4913.0
IGKV1-33 5570.0 -6751.0
IGKV1-5 5340.0 -9482.0
IGKV1D-39 2361.0 -3975.0
IGKV2-28 600.0 -6240.0
IGKV2-30 2124.0 -5952.0
IGKV2D-28 -8241.0 -7171.0
IGKV3-11 4335.0 -8929.0
IGKV3-15 3182.0 -9110.0
IGKV3-20 3477.0 -8253.0
IGKV3D-20 -604.0 -487.0
IGKV4-1 5759.0 -5700.0
IGKV5-2 3670.0 -6960.0
IGLC1 -2564.0 -7780.0
IGLC2 -3391.0 -9023.0
IGLC3 -211.0 -3454.0
IGLC7 -5718.0 -8734.0
IGLV1-36 -1581.0 -5381.0
IGLV1-40 -5815.0 -8593.0
IGLV1-44 3169.0 -7580.0
IGLV1-47 -657.0 -7558.0
IGLV1-51 -1719.0 -7074.0
IGLV10-54 3553.0 -6006.0
IGLV2-11 1826.0 -4201.0
IGLV2-14 -4545.0 -8212.0
IGLV2-18 5165.0 -4216.0
IGLV2-23 4476.0 -5875.0
IGLV2-8 4817.0 -8917.0
IGLV3-1 -5764.0 -8993.0
IGLV3-12 -6620.0 -5525.0
IGLV3-19 2884.0 -7478.0
IGLV3-21 -1967.0 -5619.0
IGLV3-25 -5461.0 -6576.0
IGLV3-27 -8634.0 -4435.0
IGLV4-69 -1909.0 -6359.0
IGLV5-45 5252.0 -9604.0
IGLV6-57 4672.0 -7639.0
IGLV7-43 165.0 2135.0
IGLV7-46 6144.0 -6715.0
IGLV8-61 3943.0 -3641.0
INPP5D -10748.0 -563.0
IRF1 2037.0 -10547.0
IRF2 8634.0 6493.0
ITGA1 8879.0 9691.0
ITGA10 2634.0 -570.0
ITGA2 4859.0 -2582.0
ITGA2B 8831.0 9692.0
ITGA3 -5445.0 -9086.0
ITGA4 -8536.0 -9695.0
ITGA5 4212.0 9070.0
ITGA6 1881.0 -7284.0
ITGAL -10521.0 -8351.0
ITGAM 10114.0 10483.0
ITGAV 4141.0 7107.0
ITGAX 4703.0 8540.0
ITGB1 -332.0 1996.0
ITGB2 9132.0 10614.0
ITGB3 7696.0 8680.0
ITIH3 -1661.0 -2817.0
ITIH4 -4505.0 -2214.0
ITPK1 4623.0 9253.0
ITPR1 -9755.0 -3689.0
ITPR2 4786.0 9335.0
ITPR3 -8426.0 -7902.0
JAK2 8894.0 -2339.0
JAM2 -364.0 2491.0
JAM3 2783.0 5396.0
JAML 9535.0 8574.0
JCHAIN 5415.0 -8049.0
JMJD1C 3594.0 1930.0
KCNMA1 -2938.0 8693.0
KCNMB1 -1724.0 920.0
KCNMB3 2148.0 6143.0
KCNMB4 9513.0 8973.0
KDM1A -8434.0 -1742.0
KIF11 3737.0 2621.0
KIF13B -1533.0 8167.0
KIF15 -449.0 425.0
KIF16B 6483.0 4873.0
KIF18A -2850.0 622.0
KIF18B 1574.0 -51.0
KIF19 -10505.0 -9709.0
KIF1B 7790.0 8663.0
KIF1C 7961.0 9111.0
KIF20A 6379.0 5509.0
KIF20B -1910.0 -5769.0
KIF21A -9783.0 -10049.0
KIF21B -10604.0 -6590.0
KIF22 -10509.0 -10695.0
KIF23 8848.0 7278.0
KIF26A 6834.0 -7906.0
KIF26B -10289.0 -9057.0
KIF27 2910.0 -4715.0
KIF28P -8008.0 -5405.0
KIF2A -6211.0 -747.0
KIF2C 7577.0 4013.0
KIF3A -8157.0 -10124.0
KIF3B 401.0 7605.0
KIF3C -1903.0 8405.0
KIF4A -1608.0 5848.0
KIF5A -6614.0 -7384.0
KIF5B 9763.0 9072.0
KIF5C -3207.0 -10063.0
KIF6 3441.0 2876.0
KIF9 -1464.0 5983.0
KIFAP3 -5888.0 -4431.0
KIFC1 1080.0 -113.0
KIFC2 2690.0 -1229.0
KLC1 1637.0 6402.0
KLC2 -4678.0 -6163.0
KLC3 5293.0 7555.0
KLC4 -8715.0 -7444.0
KLKB1 -280.0 -5832.0
KRAS 4388.0 5328.0
L1CAM 1239.0 -4478.0
LAMP2 9626.0 9234.0
LAT -8158.0 -10401.0
LCK -9185.0 -10569.0
LCP2 5338.0 -3004.0
LGALS3BP -278.0 -10598.0
LHFPL2 9993.0 10508.0
LRP8 -3317.0 8175.0
LY6G6F 6222.0 9342.0
LYN 8483.0 8583.0
MAFF 1864.0 -4157.0
MAFG 10265.0 10293.0
MAFK -2739.0 -4234.0
MAGED2 -5635.0 1105.0
MANF 7239.0 1636.0
MAPK1 -1086.0 9427.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MERTK 2373.0 9198.0
MFN1 -7216.0 1013.0
MFN2 -1266.0 7911.0
MGLL 5785.0 8910.0
MICAL1 538.0 8938.0
MIF -427.0 -5003.0
MMP1 8623.0 7665.0
MMRN1 7311.0 8075.0
MPL -1282.0 2589.0
MYB 8064.0 1791.0
NFE2 10281.0 10299.0
NHLRC2 -4230.0 -5211.0
NOS1 -86.0 528.0
NOS3 7751.0 -4608.0
NRAS 8582.0 7708.0
OLA1 9281.0 7615.0
OLR1 9142.0 -629.0
ORAI1 -8363.0 -7067.0
ORAI2 -2897.0 4779.0
ORM1 9208.0 6694.0
ORM2 1731.0 -2088.0
P2RX1 566.0 10417.0
P2RX4 9476.0 9713.0
P2RX5 -2226.0 -755.0
P2RX7 7506.0 2020.0
P2RY1 -7831.0 10440.0
P2RY12 -1550.0 5827.0
PAFAH2 -10985.0 -9728.0
PCYOX1L 2112.0 -3420.0
PDE11A 4051.0 3674.0
PDE1B 4828.0 8012.0
PDE2A -8555.0 -3776.0
PDE5A 1663.0 6785.0
PDE9A 2294.0 -6591.0
PDGFA 1176.0 5657.0
PDGFB -8368.0 -7863.0
PDPK1 -54.0 8056.0
PECAM1 7190.0 9387.0
PF4 3055.0 6229.0
PF4V1 -5499.0 -1005.0
PFN1 1471.0 6861.0
PHACTR2 -1263.0 7436.0
PHF21A 8929.0 10510.0
PICK1 -5745.0 7024.0
PIK3CA 5168.0 6821.0
PIK3CB 9880.0 9707.0
PIK3CG -9133.0 3842.0
PIK3R1 -7314.0 -9108.0
PIK3R2 2369.0 6022.0
PIK3R3 -10971.0 -7175.0
PIK3R5 -10408.0 -5867.0
PIK3R6 6288.0 8699.0
PLA2G4A 10226.0 10618.0
PLAT 5536.0 -2047.0
PLAU 4112.0 3352.0
PLAUR 9724.0 9965.0
PLCG1 -5836.0 -10187.0
PLCG2 -6227.0 6708.0
PLEK -3117.0 3467.0
PLG 299.0 -2400.0
PPBP 5440.0 6001.0
PPIA 285.0 1417.0
PPIL2 -8812.0 -3033.0
PPP2CA 9766.0 8577.0
PPP2CB 9136.0 9093.0
PPP2R1A 1997.0 5379.0
PPP2R1B 3691.0 1706.0
PPP2R5A -3440.0 4169.0
PPP2R5B 4569.0 7252.0
PPP2R5C -9892.0 -8496.0
PPP2R5D -5620.0 3209.0
PPP2R5E 522.0 2302.0
PRCP 9464.0 9217.0
PRKACA 9995.0 10558.0
PRKACB -8479.0 -10448.0
PRKAR1A 8904.0 9754.0
PRKAR1B 7778.0 8646.0
PRKAR2A 1151.0 7558.0
PRKAR2B 4069.0 6461.0
PRKCA 2691.0 1966.0
PRKCB -4906.0 9024.0
PRKCD 9710.0 9721.0
PRKCE -10688.0 -925.0
PRKCH -10885.0 -10674.0
PRKCQ -9967.0 -10691.0
PRKCZ -10726.0 -9780.0
PRKG1 6638.0 5530.0
PRKG2 -7286.0 -6385.0
PROC -10123.0 -964.0
PROCR -10118.0 -7931.0
PROS1 8002.0 7705.0
PRTN3 10009.0 6834.0
PSAP 8066.0 8239.0
PTGIR -5450.0 -8455.0
PTK2 4992.0 3213.0
PTPN1 -7223.0 8628.0
PTPN11 3471.0 9688.0
PTPN6 3230.0 7923.0
QSOX1 9888.0 10475.0
RAB27B -6595.0 4754.0
RAB5A 9230.0 7808.0
RAC1 9345.0 9946.0
RAC2 -1305.0 4460.0
RACGAP1 4139.0 4294.0
RAD51B 2835.0 9112.0
RAD51C -1745.0 -6339.0
RAF1 8083.0 7846.0
RAP1A 9691.0 8186.0
RAP1B -3254.0 7324.0
RAPGEF3 -5747.0 5214.0
RASGRP1 -9188.0 -10645.0
RASGRP2 -6869.0 -9348.0
RBSN -8580.0 -3332.0
RCOR1 9761.0 9880.0
RHOA 9541.0 9090.0
RHOB -6176.0 416.0
RHOG 8649.0 8946.0
S100A10 7937.0 9315.0
SCCPDH 8217.0 9056.0
SDC2 6034.0 5778.0
SDC3 8050.0 -2699.0
SDC4 7546.0 7624.0
SELENOP 1102.0 -7075.0
SELL 9795.0 9352.0
SELP 8480.0 9339.0
SELPLG -5690.0 3719.0
SERPINA1 10186.0 10295.0
SERPINB2 10291.0 10534.0
SERPINB6 4741.0 9944.0
SERPINB8 9914.0 10128.0
SERPIND1 -1857.0 -807.0
SERPINE1 3011.0 7764.0
SERPINE2 2260.0 8010.0
SERPINF2 -10171.0 140.0
SERPING1 533.0 -10700.0
SH2B1 -3893.0 -6025.0
SH2B2 2514.0 9954.0
SH2B3 -65.0 4784.0
SHC1 3101.0 5292.0
SIN3A -8565.0 -8326.0
SIRPA 10351.0 10576.0
SIRPG 1147.0 -10205.0
SLC16A1 5760.0 3184.0
SLC16A3 8534.0 9884.0
SLC16A8 -9216.0 6532.0
SLC3A2 3731.0 6261.0
SLC7A11 -2883.0 -3045.0
SLC7A5 3880.0 2996.0
SLC7A6 1654.0 -5677.0
SLC7A7 7011.0 8916.0
SLC7A8 -299.0 2891.0
SLC8A1 9847.0 9631.0
SLC8A3 793.0 -3989.0
SOD1 3597.0 -3501.0
SOS1 2394.0 -4661.0
SPARC 7330.0 7225.0
SPN -11009.0 -10721.0
SRC -4936.0 -8846.0
SRGN 9966.0 9137.0
SRI 8230.0 7710.0
STIM1 -9782.0 6145.0
STX4 -4764.0 2706.0
STXBP2 9851.0 10088.0
STXBP3 9718.0 8688.0
SYK 9750.0 10350.0
SYTL4 234.0 9384.0
TAGLN2 5738.0 6791.0
TBXA2R -1679.0 4971.0
TEX264 -9385.0 -6429.0
TF 2007.0 3922.0
TFPI -5937.0 2440.0
TGFB1 984.0 3574.0
TGFB2 -3931.0 -4176.0
TGFB3 -6195.0 -4793.0
THBD 8308.0 10474.0
THBS1 1255.0 9820.0
TIMP1 6709.0 10267.0
TLN1 5974.0 9916.0
TMSB4X 3917.0 6032.0
TMX3 4031.0 2865.0
TNFRSF10A 4118.0 3119.0
TNFRSF10B 9743.0 6094.0
TNFRSF10D 10327.0 9907.0
TOR4A 8478.0 10155.0
TP53 -5246.0 -8954.0
TREM1 7594.0 8932.0
TRPC3 -8356.0 -765.0
TRPC6 -7554.0 2174.0
TSPAN7 3431.0 8972.0
TTN -3218.0 6253.0
TUBA4A -92.0 4474.0
VAV1 6299.0 7892.0
VAV2 -9043.0 2054.0
VAV3 -7486.0 7780.0
VCL 913.0 8321.0
VEGFA 7943.0 7054.0
VEGFB -4813.0 -5745.0
VPREB3 -2167.0 -359.0
VPS45 8107.0 4897.0
VTI1B 9366.0 9447.0
VWF 3995.0 7559.0
WDR1 -627.0 8316.0
WEE1 -9867.0 -2523.0
YES1 -10892.0 -9337.0
YWHAZ 7112.0 6341.0
ZFPM1 -10334.0 -5618.0
ZFPM2 -6357.0 -8102.0



Cellular responses to external stimuli

Cellular responses to external stimuli
metric value
setSize 503
pMANOVA 1.05e-13
p.adjustMANOVA 3.19e-12
s.dist 0.246
s.low.CRP 0.198
s.high.CRP 0.146
p.low.CRP 2.49e-14
p.high.CRP 2.3e-08




Top 20 genes
Gene low CRP high CRP
GRB10 10276 10479
LAMTOR1 10275 10468
PRDX3 10333 10346
H1-2 9984 10557
ATP6V1A 10093 10441
ANAPC15 10210 10243
NCF2 10167 10265
ATP6V0D1 10069 10341
LMNB1 10350 10018
UBE2D1 10262 10093
RB1 10070 10186
ATP6V1B2 10130 10122
YWHAE 10079 10158
NCF4 10090 10097
CYBB 10294 9839
GSR 9685 10272
ATP6V1D 9919 9993
MAPK14 10026 9803
MTF1 10000 9766
AGO4 9707 10033

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAAS -4220.0 -2848.0
ACD -3874.0 -5690.0
ACTR10 9447.0 8995.0
ACTR1A 1291.0 7735.0
AGO1 -7318.0 8369.0
AGO3 2201.0 1603.0
AGO4 9707.0 10033.0
AJUBA -2769.0 -7087.0
AKT1S1 6861.0 8235.0
ANAPC1 -9296.0 -9659.0
ANAPC10 -527.0 1902.0
ANAPC11 5022.0 6085.0
ANAPC15 10210.0 10243.0
ANAPC16 5335.0 -809.0
ANAPC2 -5345.0 -6689.0
ANAPC4 2261.0 -3709.0
ANAPC5 -8128.0 -6414.0
ANAPC7 3531.0 1520.0
AR -1905.0 4565.0
ARNT 6732.0 10010.0
ASF1A 4792.0 -5332.0
ASNS 3189.0 -6265.0
ATF2 8316.0 2303.0
ATF3 -6766.0 -10451.0
ATF4 8523.0 6223.0
ATF5 8359.0 -8834.0
ATM -9575.0 -9477.0
ATOX1 2131.0 5843.0
ATP6V0B 9087.0 9653.0
ATP6V0C 9621.0 9869.0
ATP6V0D1 10069.0 10341.0
ATP6V0E1 8986.0 9188.0
ATP6V0E2 -4949.0 -10370.0
ATP6V1A 10093.0 10441.0
ATP6V1B2 10130.0 10122.0
ATP6V1C1 10266.0 9394.0
ATP6V1C2 -1408.0 -231.0
ATP6V1D 9919.0 9993.0
ATP6V1E1 9071.0 8178.0
ATP6V1E2 9253.0 5767.0
ATP6V1F 8059.0 6808.0
ATP6V1G1 7364.0 3710.0
ATP6V1G2 -3663.0 -8648.0
ATP6V1H 8628.0 8476.0
ATP7A -7540.0 3791.0
ATR -8336.0 -6008.0
BAG1 6308.0 4246.0
BAG2 1530.0 -9257.0
BAG3 484.0 -3581.0
BAG4 8401.0 10165.0
BAG5 1346.0 -4140.0
BMI1 -1361.0 -6301.0
BMT2 8726.0 8898.0
C12orf66 -5882.0 -8231.0
CABIN1 -10170.0 -9116.0
CAMK2D -5436.0 -9961.0
CAMK2G 3580.0 -6522.0
CAPZA1 9332.0 9316.0
CAPZA2 10077.0 9039.0
CAPZB 8393.0 8843.0
CAT 9642.0 9941.0
CBX2 -8946.0 -3592.0
CBX4 -8089.0 61.0
CBX6 2343.0 6778.0
CBX8 2677.0 6583.0
CCAR2 -9013.0 -8282.0
CCNA1 2520.0 -2665.0
CCNA2 3177.0 2827.0
CCNE1 -6448.0 -9772.0
CCNE2 5682.0 6596.0
CCS 1445.0 4651.0
CDC16 -4738.0 -1477.0
CDC23 -5476.0 -5775.0
CDC26 7265.0 4357.0
CDC27 4432.0 3370.0
CDK2 -3816.0 1587.0
CDK4 -5111.0 -8839.0
CDK6 -80.0 -6922.0
CDKN1A -1680.0 4429.0
CDKN1B -8668.0 -5917.0
CDKN2A -4195.0 308.0
CDKN2B 6243.0 10124.0
CDKN2C 1554.0 9127.0
CDKN2D 4461.0 7797.0
CEBPB 3064.0 8385.0
CEBPG 7532.0 7427.0
CITED2 5353.0 4647.0
CREBBP -9358.0 1958.0
CSRP1 8674.0 8708.0
CUL2 9537.0 5772.0
CXCL8 5888.0 -3003.0
CYBA 5409.0 8122.0
CYBB 10294.0 9839.0
CYCS 7831.0 2324.0
DCTN1 -4701.0 7431.0
DCTN2 9097.0 10370.0
DCTN3 3675.0 7530.0
DCTN4 5909.0 10148.0
DCTN5 -6881.0 5731.0
DCTN6 9751.0 9405.0
DDIT3 2270.0 107.0
DEDD2 -5853.0 -1807.0
DEPDC5 -9449.0 6824.0
DNAJA1 9542.0 3865.0
DNAJA2 6470.0 6676.0
DNAJA4 -7074.0 468.0
DNAJB1 -6048.0 -7449.0
DNAJB6 5337.0 8595.0
DNAJC2 6245.0 -1400.0
DNAJC7 8878.0 9438.0
DYNC1H1 -9811.0 -4718.0
DYNC1I1 378.0 6338.0
DYNC1I2 8978.0 9397.0
DYNC1LI1 8227.0 7194.0
DYNC1LI2 909.0 7271.0
DYNLL1 6414.0 7208.0
DYNLL2 -5827.0 -2261.0
E2F1 807.0 4632.0
E2F2 7520.0 9981.0
E2F3 -1851.0 7284.0
EED -2060.0 -3357.0
EEF1A1 2936.0 -4796.0
EGLN1 2889.0 3161.0
EGLN2 -6110.0 152.0
EGLN3 -5418.0 2677.0
EHMT1 -9196.0 -2902.0
EHMT2 -10342.0 -4713.0
EIF2AK1 8035.0 9154.0
EIF2AK4 -331.0 2879.0
EIF2S1 9228.0 5747.0
EIF2S2 9166.0 7187.0
EIF2S3 7994.0 6909.0
ELOB 7369.0 8033.0
ELOC 7870.0 9351.0
EP300 -2315.0 7280.0
EP400 -9416.0 -1828.0
EPAS1 191.0 9357.0
ERF -5496.0 5912.0
ERO1A 10293.0 8674.0
ETS1 -8303.0 -10555.0
ETS2 8142.0 9687.0
EZH2 -3198.0 -8251.0
FAU -1127.0 -1637.0
FKBP4 -833.0 414.0
FKBP5 8117.0 10444.0
FLCN 1326.0 302.0
FNIP1 4369.0 4611.0
FNIP2 -7832.0 4071.0
FOS 7518.0 2641.0
FZR1 -6086.0 -3255.0
GCN1 -9131.0 -7161.0
GPX1 9841.0 9615.0
GPX2 -1463.0 -2988.0
GPX3 -5701.0 2619.0
GPX7 -227.0 -6599.0
GRB10 10276.0 10479.0
GSK3B 4111.0 7308.0
GSR 9685.0 10272.0
GSTP1 2629.0 -1335.0
H1-0 7044.0 9266.0
H1-2 9984.0 10557.0
H1-4 -9981.0 6374.0
H2AC20 -3045.0 2635.0
H2AC6 4729.0 7926.0
H2AJ 8738.0 10604.0
H2AZ1 7009.0 5660.0
H2AZ2 -809.0 1701.0
H2BC11 3513.0 8859.0
H2BC12 7081.0 10193.0
H2BC15 -7054.0 7711.0
H2BC17 2507.0 9311.0
H2BC21 8299.0 10036.0
H2BC4 1910.0 8229.0
H2BC5 3700.0 7898.0
H2BC9 1386.0 3852.0
H2BU1 -7775.0 -6129.0
H3-3A 9562.0 8829.0
H3C15 182.5 4598.5
HDAC6 -8079.0 -3650.0
HIF1A 7766.0 8740.0
HIF1AN -9616.0 1368.0
HIF3A -7424.0 5300.0
HIGD1A 8181.0 9185.0
HIKESHI 3754.0 1618.0
HIRA -10370.0 -5636.0
HMGA1 5990.0 -2616.0
HSBP1 9443.0 8823.0
HSF1 3778.0 7387.0
HSP90AA1 5650.0 1245.0
HSP90AB1 4616.0 -5342.0
HSPA12A -7982.0 4970.0
HSPA12B 2060.0 -696.0
HSPA13 7058.0 -753.0
HSPA14 3583.0 -4954.0
HSPA1A 8518.0 7125.0
HSPA1B 4687.0 5369.0
HSPA1L 998.0 1705.0
HSPA2 1282.0 8124.0
HSPA4 8298.0 7899.0
HSPA4L -4219.0 5861.0
HSPA5 9415.0 6475.0
HSPA6 4663.0 3881.0
HSPA7 -6930.0 -8549.0
HSPA8 -4222.0 -8984.0
HSPA9 -1007.0 -4614.0
HSPH1 -3822.0 -6902.0
ID1 -4311.0 7412.0
IGFBP7 1257.0 9806.0
IMPACT 7320.0 -1351.0
ITFG2 -7924.0 -7281.0
JUN 481.0 -1015.0
KAT5 310.0 2288.0
KDM6B 9106.0 8232.0
KPTN 5936.0 7465.0
LAMTOR1 10275.0 10468.0
LAMTOR2 6251.0 9811.0
LAMTOR3 9336.0 8131.0
LAMTOR4 -1656.0 2851.0
LAMTOR5 9968.0 8801.0
LIMD1 -10044.0 -3589.0
LMNB1 10350.0 10018.0
MAP2K3 8777.0 8502.0
MAP2K4 5525.0 7430.0
MAP2K6 8704.0 10103.0
MAP2K7 -1568.0 2972.0
MAP3K5 3708.0 7973.0
MAP4K4 6710.0 8861.0
MAPK1 -1086.0 9427.0
MAPK10 6946.0 6199.0
MAPK11 8895.0 6888.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MAPK7 -9798.0 3379.0
MAPK8 -794.0 -7374.0
MAPK9 -6911.0 1519.0
MAPKAPK2 -10648.0 4888.0
MAPKAPK3 7908.0 10021.0
MAPKAPK5 -2122.0 -4742.0
MDM2 3788.0 6943.0
MDM4 1937.0 -1455.0
MINK1 -2008.0 5786.0
MIOS 32.0 6696.0
MLST8 308.0 1090.0
MOV10 -8699.0 -9786.0
MRE11 -103.0 -6016.0
MRPL18 6655.0 3759.0
MT1E -3140.0 -32.0
MT1F 5830.0 8904.0
MT1X 7889.0 5697.0
MT2A -7912.0 -6875.0
MTF1 10000.0 9766.0
MTOR -10624.0 -2672.0
NBN 7802.0 2830.0
NCF1 7986.0 3322.0
NCF2 10167.0 10265.0
NCF4 10090.0 10097.0
NDC1 -8939.0 -10351.0
NFKB1 8527.0 5403.0
NOX5 -2379.0 5051.0
NPRL2 -9590.0 -8975.0
NPRL3 5248.0 -435.0
NR3C1 -4556.0 1036.0
NR3C2 -4046.0 -10210.0
NUDT2 6788.0 5035.0
NUP107 -8816.0 -8274.0
NUP133 -5348.0 776.0
NUP153 -6945.0 -3734.0
NUP155 -5317.0 -7756.0
NUP160 -2219.0 -8347.0
NUP188 -9248.0 -9221.0
NUP205 -7213.0 -7389.0
NUP210 -10535.0 -6252.0
NUP214 8257.0 8111.0
NUP35 -4124.0 -8851.0
NUP37 5728.0 6078.0
NUP42 2461.0 -1423.0
NUP43 -3773.0 -8208.0
NUP50 6620.0 2938.0
NUP54 6985.0 -5266.0
NUP58 9614.0 9817.0
NUP62 6407.0 -2545.0
NUP85 2286.0 -2781.0
NUP88 -8115.0 -8802.0
NUP93 -5242.0 -7982.0
NUP98 -1200.0 2149.0
P4HB 8507.0 9962.0
PHC1 -5740.0 -6201.0
PHC2 8347.0 10344.0
PHC3 -5903.0 -5109.0
POM121 -9318.0 -4714.0
POM121C -10088.0 -6969.0
POT1 3268.0 1837.0
PPP1R15A 8269.0 4866.0
PRDX1 9223.0 7690.0
PRDX2 8560.0 1885.0
PRDX3 10333.0 10346.0
PRDX5 9532.0 8827.0
PRDX6 9478.0 8747.0
PSMA1 9165.0 8953.0
PSMA2 9175.0 6486.0
PSMA3 8811.0 -3545.0
PSMA4 8595.0 258.0
PSMA5 6009.0 -5256.0
PSMA6 9365.0 6915.0
PSMA7 6006.0 7700.0
PSMB1 8548.0 3242.0
PSMB10 -972.0 -8733.0
PSMB2 8065.0 5797.0
PSMB3 8817.0 8326.0
PSMB4 4018.0 3039.0
PSMB5 8225.0 9508.0
PSMB6 6959.0 8991.0
PSMB7 9346.0 8950.0
PSMB8 5148.0 -5793.0
PSMB9 -5133.0 -10716.0
PSMC1 7220.0 8544.0
PSMC2 4967.0 6378.0
PSMC3 2824.0 4673.0
PSMC4 -9365.0 -3210.0
PSMC5 2913.0 2050.0
PSMC6 9832.0 7978.0
PSMD1 8509.0 8974.0
PSMD10 6347.0 2957.0
PSMD11 8697.0 9183.0
PSMD12 9648.0 8351.0
PSMD13 7185.0 6511.0
PSMD14 7985.0 5632.0
PSMD2 7347.0 8049.0
PSMD3 3057.0 6067.0
PSMD4 8627.0 9334.0
PSMD5 1520.0 8328.0
PSMD6 9864.0 9375.0
PSMD7 9212.0 6772.0
PSMD8 6905.0 6585.0
PSMD9 7407.0 8869.0
PSME1 -1137.0 -9489.0
PSME2 3614.0 -10267.0
PSME3 9544.0 8452.0
PSME4 -8419.0 -464.0
PSMF1 7685.0 5740.0
PTGES3 9517.0 4303.0
RAD50 -7084.0 -2899.0
RAE1 7170.0 7531.0
RANBP2 457.0 512.0
RB1 10070.0 10186.0
RBBP4 4490.0 4905.0
RBBP7 -9908.0 -7503.0
RBX1 1119.0 4750.0
RELA -2847.0 -1359.0
RHEB 9612.0 9099.0
RING1 -1586.0 -738.0
RLN1 4567.0 -9632.0
RNF2 5504.0 4715.0
RPA1 -9749.0 -9650.0
RPA2 1724.0 -6042.0
RPA3 2134.0 -6039.0
RPL10 631.0 -5696.0
RPL10A 1976.0 -6292.0
RPL11 1839.0 -3327.0
RPL12 2014.0 -5298.0
RPL13 2796.0 -3228.0
RPL13A -1728.0 -6706.0
RPL14 -1317.0 -5766.0
RPL15 5748.0 532.0
RPL17 143.0 -3476.0
RPL18 3381.0 -4456.0
RPL18A -1706.0 -4694.0
RPL19 -787.0 -4539.0
RPL21 276.0 -3918.0
RPL22 4761.0 -1687.0
RPL22L1 7231.0 -349.0
RPL23 3153.0 -1612.0
RPL23A -903.0 -7885.0
RPL24 1656.0 -1751.0
RPL26 842.0 -3483.0
RPL26L1 8258.0 7992.0
RPL27 1376.0 -417.0
RPL27A -1685.0 -3049.0
RPL28 2709.0 -1855.0
RPL29 1515.0 -3475.0
RPL3 -3958.0 -7454.0
RPL30 -2576.0 -5578.0
RPL31 -429.0 -3242.0
RPL32 219.0 -4702.0
RPL34 -1732.0 -6642.0
RPL35 -9119.0 -4134.0
RPL35A -112.0 -2513.0
RPL36 -4022.0 -4235.0
RPL36A 1606.0 -4363.0
RPL36AL 5944.0 -2052.0
RPL37 -6271.0 -3029.0
RPL37A -2362.0 -447.0
RPL38 -4515.0 -3500.0
RPL39 2137.0 350.0
RPL39L -7572.0 -3974.0
RPL4 4738.0 -2403.0
RPL41 -1299.0 -3511.0
RPL5 4105.0 -2796.0
RPL6 4935.0 -1237.0
RPL7 5143.0 -1272.0
RPL7A 1809.0 -1927.0
RPL8 1265.0 -1924.0
RPL9 700.0 -4879.0
RPLP0 6333.0 -1009.0
RPLP1 -1197.0 916.0
RPLP2 -4847.0 -5802.0
RPS10 -489.0 -4974.0
RPS11 -2316.0 -5641.0
RPS12 -4797.0 -7620.0
RPS13 5276.0 -1635.0
RPS14 -4624.0 -5393.0
RPS15 -1754.0 -3299.0
RPS15A 1269.0 -4048.0
RPS16 -2078.0 -6063.0
RPS17 -5045.0 -3169.0
RPS18 -7322.0 -6605.0
RPS19 -2989.0 -7057.0
RPS19BP1 -4171.0 2371.0
RPS2 1634.0 -3308.0
RPS20 -2911.0 -6018.0
RPS21 -1933.0 -3896.0
RPS23 772.0 -4150.0
RPS24 6586.0 1001.0
RPS25 2600.0 -3817.0
RPS26 3527.0 -5041.0
RPS27 -7168.0 -6878.0
RPS27A -1868.0 -5386.0
RPS27L 7604.0 4230.0
RPS28 -2921.0 -3626.0
RPS29 -6817.0 -4617.0
RPS3 2486.0 -5123.0
RPS3A 5865.0 -3619.0
RPS4X -677.0 -7632.0
RPS4Y1 3815.0 574.0
RPS5 -1017.0 -5500.0
RPS6 2176.0 -3737.0
RPS6KA1 1245.0 8996.0
RPS6KA2 -5842.0 2331.0
RPS6KA3 1034.0 3942.0
RPS7 1946.0 -2271.0
RPS8 3760.0 -769.0
RPS9 7673.0 4928.0
RPSA -3597.0 -5016.0
RPTOR -10446.0 -7646.0
RRAGA 3684.0 7518.0
RRAGB 4552.0 1455.0
RRAGC 7966.0 4974.0
RRAGD 9956.0 9097.0
SCMH1 3592.0 -4122.0
SEC13 6324.0 5321.0
SEH1L 8372.0 -4799.0
SEM1 5210.0 6938.0
SERPINH1 -9044.0 -8370.0
SESN1 -10173.0 -301.0
SESN2 -10650.0 5345.0
SH3BP4 -8808.0 -6433.0
SIRT1 2819.0 -1845.0
SLC38A9 4803.0 6070.0
SOD1 3597.0 -3501.0
SOD2 9488.0 2250.0
SP1 6728.0 9578.0
ST13 3964.0 108.0
STAT3 9401.0 8593.0
STIP1 -1285.0 556.0
SUZ12 4242.0 493.0
SZT2 -7049.0 -3322.0
TCIRG1 253.0 9871.0
TERF1 -2307.0 2567.0
TERF2 -1638.0 256.0
TERF2IP 76.0 5059.0
TFDP1 9979.0 8001.0
TFDP2 -10993.0 -10675.0
TINF2 -796.0 4953.0
TNFRSF21 -10898.0 -4962.0
TNIK -10219.0 -10197.0
TNRC6A -4886.0 798.0
TNRC6B -9496.0 -1984.0
TNRC6C -10483.0 -10508.0
TP53 -5246.0 -8954.0
TPR -4478.0 -7012.0
TRIB3 -7114.0 -4878.0
TXN 9660.0 8103.0
TXN2 7093.0 6979.0
TXNRD1 8785.0 8833.0
TXNRD2 9039.0 7340.0
UBA52 2067.0 260.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2C 5494.0 3509.0
UBE2D1 10262.0 10093.0
UBE2D2 5413.0 5174.0
UBE2D3 9631.0 8934.0
UBE2E1 9885.0 8679.0
UBE2S 6887.0 3531.0
UBN1 -6079.0 2358.0
VCP 7591.0 6702.0
VEGFA 7943.0 7054.0
VENTX 8182.0 1388.0
VHL -700.0 5272.0
WDR24 1118.0 -3254.0
WDR59 -5325.0 -6881.0
WTIP -5731.0 -4952.0
YWHAE 10079.0 10158.0



Transport of small molecules

Transport of small molecules
metric value
setSize 554
pMANOVA 2.73e-13
p.adjustMANOVA 8.08e-12
s.dist 0.238
s.low.CRP 0.16
s.high.CRP 0.176
p.low.CRP 1.31e-10
p.high.CRP 1.22e-12




Top 20 genes
Gene low CRP high CRP
MICU1 10334 10531
ATP6V0A1 10207 10551
ASPH 10101 10538
GNG10 10307 10252
PRKACA 9995 10558
SLC1A3 10174 10371
ATP6V1A 10093 10441
CYB5R1 10052 10467
ATP6V0D1 10069 10341
AQP9 9892 10522
FBXL5 10325 10075
TRPV4 9902 10480
SLC11A1 9804 10582
ANO10 10066 10198
ATP6V1B2 10130 10122
CA1 10237 10011
MCU 10263 9958
SLC36A1 9705 10527
ERLIN1 9922 10112
TRPM2 9977 10050

Click HERE to show all gene set members

All member genes
low CRP high CRP
A2M -7493 -9192
ABCA1 4951 6830
ABCA10 -5522 -6466
ABCA2 -10870 -9605
ABCA3 -10372 -9956
ABCA5 3050 -8264
ABCA6 3142 3848
ABCA7 -3522 -2674
ABCA9 3690 5223
ABCB1 -10965 -10420
ABCB10 4325 8358
ABCB4 -8019 -3110
ABCB6 7279 5608
ABCB7 4386 -56
ABCB8 847 -1199
ABCB9 4630 -6998
ABCC1 -3572 1312
ABCC10 -8573 -1363
ABCC2 -2800 -2702
ABCC3 -4603 7268
ABCC4 4731 8657
ABCC5 -6370 862
ABCC6 1209 3452
ABCC9 -4895 -1889
ABCD1 5996 7409
ABCD2 -2397 -10120
ABCD3 7789 9378
ABCF1 -5513 -6187
ABCG1 -6697 -8303
ABCG2 -6606 -1925
ABCG8 8787 2935
ACO1 -1335 -8966
ADCY2 -3835 2899
ADCY3 9752 10224
ADCY4 4464 2329
ADCY5 -10012 -4366
ADCY6 -5852 -3739
ADCY7 -9455 -1458
ADCY9 -8919 1933
ADD1 -6996 7592
ADD2 -1321 -4817
ADD3 2524 6167
AFG3L2 -2518 -7253
AHCYL2 -462 2124
AKAP1 -5118 -9867
ALAD 5688 9906
ALB 5157 1598
AMN -1633 -2567
ANGPTL4 -7888 2021
ANKH -9143 -10577
ANO10 10066 10198
ANO5 6509 716
ANO6 7295 8568
ANO7 6132 -6792
ANO8 3927 6336
ANO9 1822 -9375
AP2A1 -5326 9611
AP2A2 5529 9467
AP2B1 -8369 3155
AP2M1 7928 9269
AP2S1 8593 9630
APOA2 7224 7075
APOBR 6831 8409
APOE -4921 3265
AQP1 7854 7172
AQP10 5233 9113
AQP11 2045 -5239
AQP3 1403 -10554
AQP7 -8530 -8472
AQP9 9892 10522
ARL2 3396 3132
ARL2BP 1755 -2844
ASIC1 -239 -3447
ASIC3 3301 -8709
ASPH 10101 10538
ATP10A -10169 -10343
ATP10B 6818 2230
ATP10D -1914 1309
ATP11A 6284 9116
ATP11B -350 6286
ATP11C 902 4476
ATP13A1 -4694 -4041
ATP13A2 -8312 5016
ATP13A4 -8031 -2893
ATP1A1 2079 5849
ATP1A3 -10629 -10011
ATP1A4 1140 1500
ATP1B1 -8554 -5287
ATP1B2 6531 7889
ATP1B3 -1519 3938
ATP2A1 -4842 -734
ATP2A2 7987 8967
ATP2A3 -10436 -1355
ATP2B1 -3461 -5580
ATP2B4 -10562 922
ATP2C1 179 8668
ATP2C2 8336 8410
ATP6AP1 4019 10005
ATP6V0A1 10207 10551
ATP6V0A2 -10746 -8412
ATP6V0B 9087 9653
ATP6V0C 9621 9869
ATP6V0D1 10069 10341
ATP6V0E1 8986 9188
ATP6V0E2 -4949 -10370
ATP6V1A 10093 10441
ATP6V1B2 10130 10122
ATP6V1C1 10266 9394
ATP6V1C2 -1408 -231
ATP6V1D 9919 9993
ATP6V1E1 9071 8178
ATP6V1E2 9253 5767
ATP6V1F 8059 6808
ATP6V1G1 7364 3710
ATP6V1G2 -3663 -8648
ATP6V1H 8628 8476
ATP7A -7540 3791
ATP7B 2250 7660
ATP8A1 -10266 -10371
ATP8A2 -1275 -6492
ATP8B1 -414 -3610
ATP8B2 -3130 -10402
ATP8B3 -262 6476
ATP8B4 7565 8129
ATP9A -10794 5626
ATP9B -747 8285
AVPR2 3307 -4195
BEST1 8440 7527
BEST2 7352 -278
BEST3 5211 7680
BEST4 -727 -7740
BMP1 -8968 2333
BSG 9321 9898
BSND 1042 5088
CA1 10237 10011
CA2 1256 5218
CA4 7084 9371
CALM1 -4337 1051
CAMK2D -5436 -9961
CAMK2G 3580 -6522
CAND1 1355 -1576
CES3 -10537 -4824
CETP 8400 1851
CLCN1 1046 3054
CLCN2 -1747 -1059
CLCN3 5795 9689
CLCN4 -333 6727
CLCN5 8572 7874
CLCN6 1006 2480
CLCN7 -108 -380
CLIC2 -2819 -2183
CLTA 9206 9264
CLTC 9482 10359
CP -10052 1836
CTNS 1070 8505
CUBN 3637 -8340
CUL1 7475 -10175
CUTC -3227 5165
CYB5R1 10052 10467
CYB5R2 8769 10354
CYB5R4 9627 9455
CYB5RL -8983 -9075
CYBRD1 3224 6665
DERL1 -5393 -6496
DERL2 5626 4860
DERL3 -7423 -6029
DMTN 9458 7925
EIF2S1 9228 5747
EIF2S2 9166 7187
EIF2S3 7994 6909
EMB 9369 8627
ERLEC1 3753 5744
ERLIN1 9922 10112
ERLIN2 8606 10317
FBXL5 10325 10075
FKBP1B 3184 8711
FLVCR1 -8512 -1422
FTH1 1622 1016
FTL 9418 9788
FURIN 7688 10324
FXYD1 -1553 -3380
FXYD2 -6794 -5885
FXYD3 -10548 -2169
FXYD6 8713 6059
FXYD7 1589 -7774
GLRX3 8422 1328
GNAS 4056 6487
GNB1 7951 9297
GNB2 8365 8530
GNB3 9486 -8169
GNB4 9757 8191
GNB5 -762 -205
GNG10 10307 10252
GNG11 4608 5846
GNG2 -10288 -2836
GNG3 6662 1225
GNG4 -1513 -1627
GNG5 9805 9666
GNG7 -5188 -5336
GNG8 -5154 2284
GNGT2 -10923 -9575
HBA1 9695 8704
HBB 9671 6093
HDLBP 6896 10032
HFE 10269 7986
HMOX1 6215 10321
HMOX2 -9635 -10507
IREB2 4802 9966
KCNJ11 -141 2587
LCAT 1660 -3253
LCN12 -10064 -7143
LCN15 4121 2791
LCN2 9492 6870
LDLR 2581 7296
LDLRAP1 118 -9996
LETM1 -9173 -453
LIPA 7915 9926
LIPC -6743 -2328
LIPG 75 978
LMF1 44 -7708
LMF2 -1583 -7609
LPL -4695 5136
LRRC8A -10141 -6860
LRRC8B 3941 7583
LRRC8C 8807 -2799
LRRC8D 6874 5813
LSR 3714 -7480
MAGT1 4037 5258
MBTPS1 -1835 5184
MBTPS2 1231 5741
MCOLN1 1384 8921
MCOLN2 -8431 -8536
MCOLN3 7062 -6985
MCU 10263 9958
MCUB 7996 -2236
MFSD4B 1885 1299
MICU1 10334 10531
MICU2 4618 2705
MICU3 2919 -7098
MMGT1 7464 7571
MRS2 4670 -442
MYLIP -3400 -9301
MYO5B -8657 -4822
NCEH1 9783 10146
NEDD4L 4410 9142
NEDD8 5330 8439
NIPA1 -9950 -7076
NIPA2 1584 6872
NIPAL1 -3930 2934
NIPAL2 4867 7142
NIPAL3 -3710 -8507
NIPAL4 -4159 3746
NPC1 -10945 -7785
NPC2 8648 6362
NR1H2 4953 7742
NR1H3 -3942 -2012
OS9 9572 10053
OSTM1 6982 7568
P4HB 8507 9962
PARL 9207 10364
PCSK5 1198 7008
PCSK6 8733 9709
PDZD11 -3651 -3584
PEX19 4048 7906
PEX3 -5531 -10289
PHB 4244 -2118
PHB2 4595 2080
PLTP 581 9199
PMPCA 1173 -6470
PMPCB 3892 1819
PRKACA 9995 10558
PRKACB -8479 -10448
PRKAR1A 8904 9754
PRKAR1B 7778 8646
PRKAR2A 1151 7558
PRKAR2B 4069 6461
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
RAB11A 9367 8536
RAB11FIP2 7275 5512
RAF1 8083 7846
RNF185 6388 8065
RNF5 -7305 -918
RPS27A -1868 -5386
RSC1A1 4601 -253
RUNX1 6393 8481
RYR1 -7812 831
RYR2 -324 9667
RYR3 -6661 -7179
SAR1B 9412 8914
SCARB1 6192 5385
SCNN1A -6206 4131
SCNN1D 1235 -6831
SEL1L 6263 8390
SEM1 5210 6938
SGK1 8332 -90
SGK2 542 -1694
SGK3 10113 8512
SKP1 8911 4204
SLC11A1 9804 10582
SLC11A2 7073 3742
SLC12A1 6035 -2475
SLC12A2 -8974 -9768
SLC12A3 -10024 -4872
SLC12A4 -3275 1087
SLC12A6 4854 9333
SLC12A7 -5382 -6484
SLC13A3 -10532 -6023
SLC13A4 -925 -3773
SLC13A5 2293 2138
SLC14A1 -3405 -5206
SLC14A2 -7428 -321
SLC15A2 1501 7772
SLC15A3 8569 9664
SLC15A4 -7633 6832
SLC16A1 5760 3184
SLC16A10 4537 -9394
SLC16A3 8534 9884
SLC16A7 1274 8797
SLC16A8 -9216 6532
SLC17A5 5214 7726
SLC17A7 -2667 1472
SLC18A1 -9003 -9176
SLC18A2 -3914 -2830
SLC1A2 3992 392
SLC1A3 10174 10371
SLC1A4 -8856 -9528
SLC1A5 9025 6521
SLC1A6 5935 789
SLC1A7 -9813 -8195
SLC20A1 -7256 -10186
SLC20A2 -10715 -5064
SLC22A1 -3791 4811
SLC22A15 8474 10530
SLC22A16 8558 6704
SLC22A17 3568 -6010
SLC22A18 -1932 7440
SLC22A4 9822 9496
SLC22A5 8103 9235
SLC24A1 -8756 -3911
SLC24A2 5111 3789
SLC24A3 3759 1898
SLC24A4 8543 7730
SLC25A10 -9794 -8478
SLC25A18 2021 3739
SLC25A22 3818 -6979
SLC25A26 -7681 -10622
SLC25A29 -5672 1674
SLC25A4 -8141 -9466
SLC25A5 1563 2136
SLC25A6 2878 3468
SLC26A1 -6617 -7798
SLC26A11 -5341 -8079
SLC26A2 -4754 3163
SLC26A6 6186 10025
SLC27A1 8348 8149
SLC27A4 -5238 2577
SLC28A2 6998 -2859
SLC28A3 4902 8184
SLC29A1 -8449 5777
SLC29A2 -3711 -9002
SLC29A3 3085 6245
SLC29A4 -5706 -2979
SLC2A1 -10701 -8961
SLC2A10 -5947 -2541
SLC2A11 127 -4381
SLC2A12 -6902 -4748
SLC2A13 -3237 4102
SLC2A14 -5239 8769
SLC2A3 10169 9727
SLC2A6 -2240 -1465
SLC2A8 -9818 -10384
SLC2A9 8739 3153
SLC30A1 8096 8654
SLC30A2 -1302 1
SLC30A5 4110 396
SLC30A6 6221 4105
SLC30A7 2299 -2931
SLC31A1 9373 10384
SLC33A1 3665 1419
SLC34A1 -168 -2660
SLC34A2 4161 -3802
SLC34A3 -5949 -5935
SLC35A1 9584 8867
SLC35A2 -5935 1912
SLC35A3 956 -5401
SLC35B2 -7930 -5440
SLC35B3 8568 7215
SLC35B4 -6917 9027
SLC35C1 -420 442
SLC35D1 -9609 -1243
SLC35D2 6867 7970
SLC36A1 9705 10527
SLC36A2 -6264 -1061
SLC36A4 7925 9685
SLC38A1 -9228 -8568
SLC38A2 8145 6755
SLC38A5 2701 -7052
SLC39A1 9250 9768
SLC39A10 -9222 -7476
SLC39A14 -1969 -7934
SLC39A3 957 4834
SLC39A4 4288 3277
SLC39A5 335 -2154
SLC39A6 -2319 -4289
SLC39A7 1104 7030
SLC39A8 9661 10210
SLC3A1 -8138 -4735
SLC3A2 3731 6261
SLC40A1 9619 5856
SLC41A1 -8238 -9773
SLC41A2 -10873 -9505
SLC43A1 -5825 -2732
SLC43A2 8090 9844
SLC44A1 8910 9654
SLC44A2 -3421 2167
SLC44A5 4109 -573
SLC45A3 -6029 -10457
SLC46A1 -6011 -57
SLC47A1 -6703 1088
SLC47A2 -7021 -4160
SLC4A1 9896 9193
SLC4A10 -5273 -6884
SLC4A2 4857 8355
SLC4A3 -10809 -9692
SLC4A4 -10859 -8817
SLC4A5 3733 -8065
SLC4A7 -9624 -10216
SLC4A8 -8464 -7022
SLC50A1 6840 4130
SLC5A10 -4261 -10224
SLC5A11 4739 -1671
SLC5A12 3160 2548
SLC5A2 2043 -6862
SLC5A3 -10405 -8987
SLC5A5 4332 -7342
SLC5A6 -3378 -4394
SLC5A9 -5518 7534
SLC66A1 -124 5324
SLC6A1 2204 2129
SLC6A12 8892 680
SLC6A20 -7757 -1119
SLC6A6 7811 9814
SLC6A9 8932 5990
SLC7A1 -1218 -6768
SLC7A11 -2883 -3045
SLC7A5 3880 2996
SLC7A6 1654 -5677
SLC7A7 7011 8916
SLC7A8 -299 2891
SLC8A1 9847 9631
SLC8A3 793 -3989
SLC8B1 6570 9373
SLC9A1 1175 9205
SLC9A3 758 -8821
SLC9A5 -4528 -6717
SLC9A6 2791 6385
SLC9A7 -9800 -752
SLC9A8 -5200 5092
SLC9A9 7467 9719
SLC9B1 -1308 -5120
SLC9B2 -9107 -8124
SLCO2B1 7490 9554
SLCO3A1 8362 8560
SLCO4A1 3138 9464
SLCO4C1 -9301 4048
SMDT1 -1492 -1047
SOAT1 8397 8988
SOAT2 5079 -4880
SPG7 -5687 -9286
SRI 8230 7710
STEAP3 2363 7339
STOM 2462 8162
STOML2 1086 -1104
TCIRG1 253 9871
TF 2007 3922
TFR2 -9093 -7487
TFRC 3905 5758
TPCN1 8287 3175
TPCN2 5663 7454
TRPC1 2523 -9638
TRPC3 -8356 -765
TRPC4AP -2332 1607
TRPC6 -7554 2174
TRPM2 9977 10050
TRPM3 3065 5304
TRPM4 9164 6249
TRPM6 -5168 -2039
TRPM7 -5599 -1902
TRPV1 -3502 -9282
TRPV2 -9626 -1228
TRPV3 -9789 -4181
TRPV4 9902 10480
TRPV6 -151 -7741
TSC22D3 -6051 4776
TTYH1 -3772 3541
TTYH2 -6656 -5068
TTYH3 489 9675
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UNC79 -2823 7233
UNC80 -8406 -2847
VCP 7591 6702
VDAC1 7258 5858
VDAC2 9090 9227
VDAC3 3161 3488
VLDLR -8198 1805
WNK1 -2533 7297
WNK2 -965 -3309
WNK3 -3511 -3692
WWP1 333 -9676
YME1L1 7887 7934
ZDHHC8 -4412 -2297



Cellular responses to stress

Cellular responses to stress
metric value
setSize 497
pMANOVA 3.13e-13
p.adjustMANOVA 9.09e-12
s.dist 0.242
s.low.CRP 0.196
s.high.CRP 0.142
p.low.CRP 6.6e-14
p.high.CRP 5.74e-08




Top 20 genes
Gene low CRP high CRP
GRB10 10276 10479
LAMTOR1 10275 10468
PRDX3 10333 10346
H1-2 9984 10557
ATP6V1A 10093 10441
ANAPC15 10210 10243
NCF2 10167 10265
ATP6V0D1 10069 10341
LMNB1 10350 10018
UBE2D1 10262 10093
RB1 10070 10186
ATP6V1B2 10130 10122
YWHAE 10079 10158
NCF4 10090 10097
CYBB 10294 9839
GSR 9685 10272
ATP6V1D 9919 9993
MAPK14 10026 9803
AGO4 9707 10033
ATP6V1C1 10266 9394

Click HERE to show all gene set members

All member genes
low CRP high CRP
AAAS -4220.0 -2848.0
ACD -3874.0 -5690.0
ACTR10 9447.0 8995.0
ACTR1A 1291.0 7735.0
AGO1 -7318.0 8369.0
AGO3 2201.0 1603.0
AGO4 9707.0 10033.0
AJUBA -2769.0 -7087.0
AKT1S1 6861.0 8235.0
ANAPC1 -9296.0 -9659.0
ANAPC10 -527.0 1902.0
ANAPC11 5022.0 6085.0
ANAPC15 10210.0 10243.0
ANAPC16 5335.0 -809.0
ANAPC2 -5345.0 -6689.0
ANAPC4 2261.0 -3709.0
ANAPC5 -8128.0 -6414.0
ANAPC7 3531.0 1520.0
AR -1905.0 4565.0
ARNT 6732.0 10010.0
ASF1A 4792.0 -5332.0
ASNS 3189.0 -6265.0
ATF2 8316.0 2303.0
ATF3 -6766.0 -10451.0
ATF4 8523.0 6223.0
ATF5 8359.0 -8834.0
ATM -9575.0 -9477.0
ATOX1 2131.0 5843.0
ATP6V0B 9087.0 9653.0
ATP6V0C 9621.0 9869.0
ATP6V0D1 10069.0 10341.0
ATP6V0E1 8986.0 9188.0
ATP6V0E2 -4949.0 -10370.0
ATP6V1A 10093.0 10441.0
ATP6V1B2 10130.0 10122.0
ATP6V1C1 10266.0 9394.0
ATP6V1C2 -1408.0 -231.0
ATP6V1D 9919.0 9993.0
ATP6V1E1 9071.0 8178.0
ATP6V1E2 9253.0 5767.0
ATP6V1F 8059.0 6808.0
ATP6V1G1 7364.0 3710.0
ATP6V1G2 -3663.0 -8648.0
ATP6V1H 8628.0 8476.0
ATP7A -7540.0 3791.0
ATR -8336.0 -6008.0
BAG1 6308.0 4246.0
BAG2 1530.0 -9257.0
BAG3 484.0 -3581.0
BAG4 8401.0 10165.0
BAG5 1346.0 -4140.0
BMI1 -1361.0 -6301.0
BMT2 8726.0 8898.0
C12orf66 -5882.0 -8231.0
CABIN1 -10170.0 -9116.0
CAMK2D -5436.0 -9961.0
CAMK2G 3580.0 -6522.0
CAPZA1 9332.0 9316.0
CAPZA2 10077.0 9039.0
CAPZB 8393.0 8843.0
CAT 9642.0 9941.0
CBX2 -8946.0 -3592.0
CBX4 -8089.0 61.0
CBX6 2343.0 6778.0
CBX8 2677.0 6583.0
CCAR2 -9013.0 -8282.0
CCNA1 2520.0 -2665.0
CCNA2 3177.0 2827.0
CCNE1 -6448.0 -9772.0
CCNE2 5682.0 6596.0
CCS 1445.0 4651.0
CDC16 -4738.0 -1477.0
CDC23 -5476.0 -5775.0
CDC26 7265.0 4357.0
CDC27 4432.0 3370.0
CDK2 -3816.0 1587.0
CDK4 -5111.0 -8839.0
CDK6 -80.0 -6922.0
CDKN1A -1680.0 4429.0
CDKN1B -8668.0 -5917.0
CDKN2A -4195.0 308.0
CDKN2B 6243.0 10124.0
CDKN2C 1554.0 9127.0
CDKN2D 4461.0 7797.0
CEBPB 3064.0 8385.0
CEBPG 7532.0 7427.0
CITED2 5353.0 4647.0
CREBBP -9358.0 1958.0
CUL2 9537.0 5772.0
CXCL8 5888.0 -3003.0
CYBA 5409.0 8122.0
CYBB 10294.0 9839.0
CYCS 7831.0 2324.0
DCTN1 -4701.0 7431.0
DCTN2 9097.0 10370.0
DCTN3 3675.0 7530.0
DCTN4 5909.0 10148.0
DCTN5 -6881.0 5731.0
DCTN6 9751.0 9405.0
DDIT3 2270.0 107.0
DEDD2 -5853.0 -1807.0
DEPDC5 -9449.0 6824.0
DNAJA1 9542.0 3865.0
DNAJA2 6470.0 6676.0
DNAJA4 -7074.0 468.0
DNAJB1 -6048.0 -7449.0
DNAJB6 5337.0 8595.0
DNAJC2 6245.0 -1400.0
DNAJC7 8878.0 9438.0
DYNC1H1 -9811.0 -4718.0
DYNC1I1 378.0 6338.0
DYNC1I2 8978.0 9397.0
DYNC1LI1 8227.0 7194.0
DYNC1LI2 909.0 7271.0
DYNLL1 6414.0 7208.0
DYNLL2 -5827.0 -2261.0
E2F1 807.0 4632.0
E2F2 7520.0 9981.0
E2F3 -1851.0 7284.0
EED -2060.0 -3357.0
EEF1A1 2936.0 -4796.0
EGLN1 2889.0 3161.0
EGLN2 -6110.0 152.0
EGLN3 -5418.0 2677.0
EHMT1 -9196.0 -2902.0
EHMT2 -10342.0 -4713.0
EIF2AK1 8035.0 9154.0
EIF2AK4 -331.0 2879.0
EIF2S1 9228.0 5747.0
EIF2S2 9166.0 7187.0
EIF2S3 7994.0 6909.0
ELOB 7369.0 8033.0
ELOC 7870.0 9351.0
EP300 -2315.0 7280.0
EP400 -9416.0 -1828.0
EPAS1 191.0 9357.0
ERF -5496.0 5912.0
ERO1A 10293.0 8674.0
ETS1 -8303.0 -10555.0
ETS2 8142.0 9687.0
EZH2 -3198.0 -8251.0
FAU -1127.0 -1637.0
FKBP4 -833.0 414.0
FKBP5 8117.0 10444.0
FLCN 1326.0 302.0
FNIP1 4369.0 4611.0
FNIP2 -7832.0 4071.0
FOS 7518.0 2641.0
FZR1 -6086.0 -3255.0
GCN1 -9131.0 -7161.0
GPX1 9841.0 9615.0
GPX2 -1463.0 -2988.0
GPX3 -5701.0 2619.0
GPX7 -227.0 -6599.0
GRB10 10276.0 10479.0
GSK3B 4111.0 7308.0
GSR 9685.0 10272.0
GSTP1 2629.0 -1335.0
H1-0 7044.0 9266.0
H1-2 9984.0 10557.0
H1-4 -9981.0 6374.0
H2AC20 -3045.0 2635.0
H2AC6 4729.0 7926.0
H2AJ 8738.0 10604.0
H2AZ1 7009.0 5660.0
H2AZ2 -809.0 1701.0
H2BC11 3513.0 8859.0
H2BC12 7081.0 10193.0
H2BC15 -7054.0 7711.0
H2BC17 2507.0 9311.0
H2BC21 8299.0 10036.0
H2BC4 1910.0 8229.0
H2BC5 3700.0 7898.0
H2BC9 1386.0 3852.0
H2BU1 -7775.0 -6129.0
H3-3A 9562.0 8829.0
H3C15 182.5 4598.5
HDAC6 -8079.0 -3650.0
HIF1A 7766.0 8740.0
HIF1AN -9616.0 1368.0
HIF3A -7424.0 5300.0
HIGD1A 8181.0 9185.0
HIKESHI 3754.0 1618.0
HIRA -10370.0 -5636.0
HMGA1 5990.0 -2616.0
HSBP1 9443.0 8823.0
HSF1 3778.0 7387.0
HSP90AA1 5650.0 1245.0
HSP90AB1 4616.0 -5342.0
HSPA12A -7982.0 4970.0
HSPA12B 2060.0 -696.0
HSPA13 7058.0 -753.0
HSPA14 3583.0 -4954.0
HSPA1A 8518.0 7125.0
HSPA1B 4687.0 5369.0
HSPA1L 998.0 1705.0
HSPA2 1282.0 8124.0
HSPA4 8298.0 7899.0
HSPA4L -4219.0 5861.0
HSPA5 9415.0 6475.0
HSPA6 4663.0 3881.0
HSPA7 -6930.0 -8549.0
HSPA8 -4222.0 -8984.0
HSPA9 -1007.0 -4614.0
HSPH1 -3822.0 -6902.0
ID1 -4311.0 7412.0
IGFBP7 1257.0 9806.0
IMPACT 7320.0 -1351.0
ITFG2 -7924.0 -7281.0
JUN 481.0 -1015.0
KAT5 310.0 2288.0
KDM6B 9106.0 8232.0
KPTN 5936.0 7465.0
LAMTOR1 10275.0 10468.0
LAMTOR2 6251.0 9811.0
LAMTOR3 9336.0 8131.0
LAMTOR4 -1656.0 2851.0
LAMTOR5 9968.0 8801.0
LIMD1 -10044.0 -3589.0
LMNB1 10350.0 10018.0
MAP2K3 8777.0 8502.0
MAP2K4 5525.0 7430.0
MAP2K6 8704.0 10103.0
MAP2K7 -1568.0 2972.0
MAP3K5 3708.0 7973.0
MAP4K4 6710.0 8861.0
MAPK1 -1086.0 9427.0
MAPK10 6946.0 6199.0
MAPK11 8895.0 6888.0
MAPK14 10026.0 9803.0
MAPK3 9769.0 9676.0
MAPK7 -9798.0 3379.0
MAPK8 -794.0 -7374.0
MAPK9 -6911.0 1519.0
MAPKAPK2 -10648.0 4888.0
MAPKAPK3 7908.0 10021.0
MAPKAPK5 -2122.0 -4742.0
MDM2 3788.0 6943.0
MDM4 1937.0 -1455.0
MINK1 -2008.0 5786.0
MIOS 32.0 6696.0
MLST8 308.0 1090.0
MOV10 -8699.0 -9786.0
MRE11 -103.0 -6016.0
MRPL18 6655.0 3759.0
MTOR -10624.0 -2672.0
NBN 7802.0 2830.0
NCF1 7986.0 3322.0
NCF2 10167.0 10265.0
NCF4 10090.0 10097.0
NDC1 -8939.0 -10351.0
NFKB1 8527.0 5403.0
NOX5 -2379.0 5051.0
NPRL2 -9590.0 -8975.0
NPRL3 5248.0 -435.0
NR3C1 -4556.0 1036.0
NR3C2 -4046.0 -10210.0
NUDT2 6788.0 5035.0
NUP107 -8816.0 -8274.0
NUP133 -5348.0 776.0
NUP153 -6945.0 -3734.0
NUP155 -5317.0 -7756.0
NUP160 -2219.0 -8347.0
NUP188 -9248.0 -9221.0
NUP205 -7213.0 -7389.0
NUP210 -10535.0 -6252.0
NUP214 8257.0 8111.0
NUP35 -4124.0 -8851.0
NUP37 5728.0 6078.0
NUP42 2461.0 -1423.0
NUP43 -3773.0 -8208.0
NUP50 6620.0 2938.0
NUP54 6985.0 -5266.0
NUP58 9614.0 9817.0
NUP62 6407.0 -2545.0
NUP85 2286.0 -2781.0
NUP88 -8115.0 -8802.0
NUP93 -5242.0 -7982.0
NUP98 -1200.0 2149.0
P4HB 8507.0 9962.0
PHC1 -5740.0 -6201.0
PHC2 8347.0 10344.0
PHC3 -5903.0 -5109.0
POM121 -9318.0 -4714.0
POM121C -10088.0 -6969.0
POT1 3268.0 1837.0
PPP1R15A 8269.0 4866.0
PRDX1 9223.0 7690.0
PRDX2 8560.0 1885.0
PRDX3 10333.0 10346.0
PRDX5 9532.0 8827.0
PRDX6 9478.0 8747.0
PSMA1 9165.0 8953.0
PSMA2 9175.0 6486.0
PSMA3 8811.0 -3545.0
PSMA4 8595.0 258.0
PSMA5 6009.0 -5256.0
PSMA6 9365.0 6915.0
PSMA7 6006.0 7700.0
PSMB1 8548.0 3242.0
PSMB10 -972.0 -8733.0
PSMB2 8065.0 5797.0
PSMB3 8817.0 8326.0
PSMB4 4018.0 3039.0
PSMB5 8225.0 9508.0
PSMB6 6959.0 8991.0
PSMB7 9346.0 8950.0
PSMB8 5148.0 -5793.0
PSMB9 -5133.0 -10716.0
PSMC1 7220.0 8544.0
PSMC2 4967.0 6378.0
PSMC3 2824.0 4673.0
PSMC4 -9365.0 -3210.0
PSMC5 2913.0 2050.0
PSMC6 9832.0 7978.0
PSMD1 8509.0 8974.0
PSMD10 6347.0 2957.0
PSMD11 8697.0 9183.0
PSMD12 9648.0 8351.0
PSMD13 7185.0 6511.0
PSMD14 7985.0 5632.0
PSMD2 7347.0 8049.0
PSMD3 3057.0 6067.0
PSMD4 8627.0 9334.0
PSMD5 1520.0 8328.0
PSMD6 9864.0 9375.0
PSMD7 9212.0 6772.0
PSMD8 6905.0 6585.0
PSMD9 7407.0 8869.0
PSME1 -1137.0 -9489.0
PSME2 3614.0 -10267.0
PSME3 9544.0 8452.0
PSME4 -8419.0 -464.0
PSMF1 7685.0 5740.0
PTGES3 9517.0 4303.0
RAD50 -7084.0 -2899.0
RAE1 7170.0 7531.0
RANBP2 457.0 512.0
RB1 10070.0 10186.0
RBBP4 4490.0 4905.0
RBBP7 -9908.0 -7503.0
RBX1 1119.0 4750.0
RELA -2847.0 -1359.0
RHEB 9612.0 9099.0
RING1 -1586.0 -738.0
RLN1 4567.0 -9632.0
RNF2 5504.0 4715.0
RPA1 -9749.0 -9650.0
RPA2 1724.0 -6042.0
RPA3 2134.0 -6039.0
RPL10 631.0 -5696.0
RPL10A 1976.0 -6292.0
RPL11 1839.0 -3327.0
RPL12 2014.0 -5298.0
RPL13 2796.0 -3228.0
RPL13A -1728.0 -6706.0
RPL14 -1317.0 -5766.0
RPL15 5748.0 532.0
RPL17 143.0 -3476.0
RPL18 3381.0 -4456.0
RPL18A -1706.0 -4694.0
RPL19 -787.0 -4539.0
RPL21 276.0 -3918.0
RPL22 4761.0 -1687.0
RPL22L1 7231.0 -349.0
RPL23 3153.0 -1612.0
RPL23A -903.0 -7885.0
RPL24 1656.0 -1751.0
RPL26 842.0 -3483.0
RPL26L1 8258.0 7992.0
RPL27 1376.0 -417.0
RPL27A -1685.0 -3049.0
RPL28 2709.0 -1855.0
RPL29 1515.0 -3475.0
RPL3 -3958.0 -7454.0
RPL30 -2576.0 -5578.0
RPL31 -429.0 -3242.0
RPL32 219.0 -4702.0
RPL34 -1732.0 -6642.0
RPL35 -9119.0 -4134.0
RPL35A -112.0 -2513.0
RPL36 -4022.0 -4235.0
RPL36A 1606.0 -4363.0
RPL36AL 5944.0 -2052.0
RPL37 -6271.0 -3029.0
RPL37A -2362.0 -447.0
RPL38 -4515.0 -3500.0
RPL39 2137.0 350.0
RPL39L -7572.0 -3974.0
RPL4 4738.0 -2403.0
RPL41 -1299.0 -3511.0
RPL5 4105.0 -2796.0
RPL6 4935.0 -1237.0
RPL7 5143.0 -1272.0
RPL7A 1809.0 -1927.0
RPL8 1265.0 -1924.0
RPL9 700.0 -4879.0
RPLP0 6333.0 -1009.0
RPLP1 -1197.0 916.0
RPLP2 -4847.0 -5802.0
RPS10 -489.0 -4974.0
RPS11 -2316.0 -5641.0
RPS12 -4797.0 -7620.0
RPS13 5276.0 -1635.0
RPS14 -4624.0 -5393.0
RPS15 -1754.0 -3299.0
RPS15A 1269.0 -4048.0
RPS16 -2078.0 -6063.0
RPS17 -5045.0 -3169.0
RPS18 -7322.0 -6605.0
RPS19 -2989.0 -7057.0
RPS19BP1 -4171.0 2371.0
RPS2 1634.0 -3308.0
RPS20 -2911.0 -6018.0
RPS21 -1933.0 -3896.0
RPS23 772.0 -4150.0
RPS24 6586.0 1001.0
RPS25 2600.0 -3817.0
RPS26 3527.0 -5041.0
RPS27 -7168.0 -6878.0
RPS27A -1868.0 -5386.0
RPS27L 7604.0 4230.0
RPS28 -2921.0 -3626.0
RPS29 -6817.0 -4617.0
RPS3 2486.0 -5123.0
RPS3A 5865.0 -3619.0
RPS4X -677.0 -7632.0
RPS4Y1 3815.0 574.0
RPS5 -1017.0 -5500.0
RPS6 2176.0 -3737.0
RPS6KA1 1245.0 8996.0
RPS6KA2 -5842.0 2331.0
RPS6KA3 1034.0 3942.0
RPS7 1946.0 -2271.0
RPS8 3760.0 -769.0
RPS9 7673.0 4928.0
RPSA -3597.0 -5016.0
RPTOR -10446.0 -7646.0
RRAGA 3684.0 7518.0
RRAGB 4552.0 1455.0
RRAGC 7966.0 4974.0
RRAGD 9956.0 9097.0
SCMH1 3592.0 -4122.0
SEC13 6324.0 5321.0
SEH1L 8372.0 -4799.0
SEM1 5210.0 6938.0
SERPINH1 -9044.0 -8370.0
SESN1 -10173.0 -301.0
SESN2 -10650.0 5345.0
SH3BP4 -8808.0 -6433.0
SIRT1 2819.0 -1845.0
SLC38A9 4803.0 6070.0
SOD1 3597.0 -3501.0
SOD2 9488.0 2250.0
SP1 6728.0 9578.0
ST13 3964.0 108.0
STAT3 9401.0 8593.0
STIP1 -1285.0 556.0
SUZ12 4242.0 493.0
SZT2 -7049.0 -3322.0
TCIRG1 253.0 9871.0
TERF1 -2307.0 2567.0
TERF2 -1638.0 256.0
TERF2IP 76.0 5059.0
TFDP1 9979.0 8001.0
TFDP2 -10993.0 -10675.0
TINF2 -796.0 4953.0
TNFRSF21 -10898.0 -4962.0
TNIK -10219.0 -10197.0
TNRC6A -4886.0 798.0
TNRC6B -9496.0 -1984.0
TNRC6C -10483.0 -10508.0
TP53 -5246.0 -8954.0
TPR -4478.0 -7012.0
TRIB3 -7114.0 -4878.0
TXN 9660.0 8103.0
TXN2 7093.0 6979.0
TXNRD1 8785.0 8833.0
TXNRD2 9039.0 7340.0
UBA52 2067.0 260.0
UBB 7788.0 3835.0
UBC 2562.0 2822.0
UBE2C 5494.0 3509.0
UBE2D1 10262.0 10093.0
UBE2D2 5413.0 5174.0
UBE2D3 9631.0 8934.0
UBE2E1 9885.0 8679.0
UBE2S 6887.0 3531.0
UBN1 -6079.0 2358.0
VCP 7591.0 6702.0
VEGFA 7943.0 7054.0
VENTX 8182.0 1388.0
VHL -700.0 5272.0
WDR24 1118.0 -3254.0
WDR59 -5325.0 -6881.0
WTIP -5731.0 -4952.0
YWHAE 10079.0 10158.0



Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
metric value
setSize 124
pMANOVA 3.6e-13
p.adjustMANOVA 1.02e-11
s.dist 0.491
s.low.CRP 0.378
s.high.CRP 0.314
p.low.CRP 3.72e-13
p.high.CRP 1.5e-09




Top 20 genes
Gene low CRP high CRP
ETFDH 10012 10191
SDHC 9342 9775
ETFA 9339 9616
NDUFB9 9167 9565
ATP5PB 9493 9015
ETFB 9144 9286
NDUFB3 9075 9321
ATP5F1C 9580 8671
ATP5PD 9734 8460
NDUFA4 8573 9057
NDUFB1 7433 10164
COX7A2L 9037 8303
NDUFAF1 8656 8639
SDHD 9801 7526
UQCRC1 8264 8723
TIMMDC1 8385 8473
UQCRH 8075 8773
UQCR11 8377 8061
SDHB 7368 9153
ATP5F1A 9557 6994

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACAD9 5414 4340
ATP5F1A 9557 6994
ATP5F1B 8684 6919
ATP5F1C 9580 8671
ATP5F1D 474 359
ATP5F1E 6027 6878
ATP5MC1 5471 -6148
ATP5MC2 1987 2992
ATP5MC3 7250 7383
ATP5ME -322 5177
ATP5MF 7383 8461
ATP5MG 8134 7589
ATP5PB 9493 9015
ATP5PD 9734 8460
ATP5PF 7570 8666
ATP5PO 9184 6042
COQ10A -8775 -8783
COQ10B 6069 3637
COX11 -5218 -9151
COX14 3006 -1658
COX16 8909 998
COX18 4592 -2426
COX19 1920 -3944
COX20 3257 -2193
COX4I1 5132 3979
COX5A 7687 7980
COX5B 6345 7810
COX6A1 3840 6505
COX6B1 6445 7034
COX6C 6357 4173
COX7A2L 9037 8303
COX7B 6183 6675
COX7C 910 974
COX8A 5588 7834
CYC1 -437 4720
CYCS 7831 2324
DMAC2L -3270 -3208
ECSIT 5443 4562
ETFA 9339 9616
ETFB 9144 9286
ETFDH 10012 10191
LRPPRC -21 -7930
MT-ATP6 -5000 3338
MT-ATP8 -8176 7306
MT-CO1 2995 5163
MT-CO2 2723 3643
MT-CO3 307 4978
MT-CYB -2505 365
MT-ND1 -3359 -920
MT-ND2 -6325 -4137
MT-ND3 886 1784
MT-ND4 641 3660
MT-ND5 -2601 2772
MT-ND6 6472 6305
NDUFA1 5265 7768
NDUFA10 -5642 -1013
NDUFA11 4155 -1362
NDUFA12 6496 3034
NDUFA13 2094 5390
NDUFA2 3139 5257
NDUFA3 1012 2616
NDUFA4 8573 9057
NDUFA5 4399 -1289
NDUFA6 3765 6106
NDUFA7 7692 7856
NDUFA8 8951 4747
NDUFA9 954 -153
NDUFAB1 9435 5334
NDUFAF1 8656 8639
NDUFAF2 4249 5603
NDUFAF3 4509 6763
NDUFAF4 -2041 -9027
NDUFAF5 -4385 -3905
NDUFAF6 2220 2420
NDUFAF7 -2530 5726
NDUFB1 7433 10164
NDUFB10 6206 6495
NDUFB11 -293 -282
NDUFB2 -3647 -4166
NDUFB3 9075 9321
NDUFB4 6520 6110
NDUFB5 8646 6075
NDUFB6 5249 4452
NDUFB7 2963 1058
NDUFB8 752 3261
NDUFB9 9167 9565
NDUFC1 7046 8373
NDUFC2 7348 9008
NDUFS1 5479 9340
NDUFS2 4737 7929
NDUFS3 1276 2496
NDUFS4 8342 4293
NDUFS5 4941 7336
NDUFS6 4032 6868
NDUFS7 3115 2433
NDUFS8 3125 -1053
NDUFV1 -7714 -8421
NDUFV2 9236 7085
NDUFV3 8152 7579
NUBPL -6298 -8977
PM20D1 -7373 -9620
SCO1 -560 -5166
SCO2 5178 -9665
SDHA -7420 -4414
SDHB 7368 9153
SDHC 9342 9775
SDHD 9801 7526
SLC25A14 -1042 -2588
SLC25A27 3773 -6502
SURF1 5404 1530
TACO1 4959 5943
TIMMDC1 8385 8473
TMEM126B -221 -3886
TRAP1 -4626 -9571
UCP2 -3241 4728
UCP3 -6187 -7539
UQCR10 3747 6293
UQCR11 8377 8061
UQCRB 6557 5036
UQCRC1 8264 8723
UQCRC2 9566 6489
UQCRFS1 7740 7015
UQCRH 8075 8773
UQCRQ 4092 3891



Programmed Cell Death

Programmed Cell Death
metric value
setSize 179
pMANOVA 4.51e-13
p.adjustMANOVA 1.25e-11
s.dist 0.405
s.low.CRP 0.317
s.high.CRP 0.252
p.low.CRP 2.46e-13
p.high.CRP 5.87e-09




Top 20 genes
Gene low CRP high CRP
VIM 10149 10565
H1-2 9984 10557
CD14 10063 10306
LMNB1 10350 10018
SDCBP 10246 10113
YWHAE 10079 10158
YWHAG 9489 10473
GSN 10108 9436
TLR4 9286 10255
FLOT1 9719 9737
MAPK3 9769 9676
PRKCD 9710 9721
LY96 9677 9581
PSMD6 9864 9375
APAF1 9662 9512
HMGB2 9519 9556
YWHAH 9385 9379
UNC5A 8856 9670
PSMB7 9346 8950
PSMA1 9165 8953

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACIN1 -8778 4274
ADD1 -6996 7592
AKT1 -5096 2421
AKT2 -7693 3004
AKT3 -8346 -9755
APAF1 9662 9512
APC -2802 3982
APIP 9427 7371
APPL1 2306 6705
ARHGAP10 1783 -6828
AVEN -5001 -4514
BAD 5612 7891
BAK1 6903 -1309
BAX 6346 6448
BBC3 -10504 -9296
BCAP31 3940 6441
BCL2 5399 -4548
BCL2L1 9471 8431
BCL2L11 7146 9131
BID 8351 4298
BIRC2 8116 2944
BIRC3 2030 -10298
BMF 5346 4358
BMX 7713 9372
C1QBP 6269 -1813
CARD8 4200 4980
CASP3 4165 2978
CASP6 2244 -665
CASP7 8616 1072
CASP8 -9202 -9212
CASP9 4638 9486
CD14 10063 10306
CDC37 2418 5331
CDH1 -10326 -6171
CDKN2A -4195 308
CFLAR 7530 7738
CLSPN 5905 4810
CTNNB1 1446 7186
CYCS 7831 2324
DAPK1 3008 8563
DAPK2 5100 4638
DAPK3 -4880 5138
DBNL 4127 8290
DFFA 340 5349
DFFB -7362 -4429
DIABLO -450 -4237
DNM1L 6926 8887
DSP -4419 -1253
DYNLL1 6414 7208
DYNLL2 -5827 -2261
E2F1 807 4632
FADD -3902 4370
FAS 8966 1600
FASLG -10999 -10620
FLOT1 9719 9737
FLOT2 8916 8531
FNTA 3450 -3347
GAS2 -114 -9363
GSN 10108 9436
GZMB -11006 -10285
H1-0 7044 9266
H1-2 9984 10557
H1-4 -9981 6374
HMGB1 3409 1050
HMGB2 9519 9556
HSP90AA1 5650 1245
KPNA1 3096 3012
KPNB1 67 557
LMNA -2386 2195
LMNB1 10350 10018
LY96 9677 9581
MAGED1 -10150 -10551
MAPK1 -1086 9427
MAPK3 9769 9676
MAPK8 -794 -7374
MAPT -4862 -1926
MLKL 7827 8146
NMT1 4695 7205
OCLN 944 291
OGT -6432 -5075
OMA1 8705 4009
OPA1 4563 7289
PAK2 9098 8874
PDCD6IP 8622 9034
PELI1 8918 5667
PLEC -6776 5947
PMAIP1 -6135 -9326
PPP1R13B -10256 -8799
PPP3CC -10514 -9849
PPP3R1 8749 9050
PRKCD 9710 9721
PRKCQ -9967 -10691
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
PTK2 4992 3213
RIPK1 -8110 -7415
RIPK3 -2562 6478
ROCK1 5871 8890
RPS27A -1868 -5386
SATB1 -3273 -7984
SDCBP 10246 10113
SEM1 5210 6938
SEPTIN4 9714 3676
SFN 4316 -5611
SPTAN1 -10045 -9563
STAT3 9401 8593
STK24 3598 7864
STK26 -9988 -7398
STUB1 -5098 -1439
TFDP1 9979 8001
TFDP2 -10993 -10675
TICAM1 6577 5314
TICAM2 9445 5256
TJP1 -85 -2268
TJP2 1843 -688
TLR4 9286 10255
TNFRSF10A 4118 3119
TNFRSF10B 9743 6094
TNFSF10 9924 -1909
TP53 -5246 -8954
TP53BP2 2703 7606
TP63 -5835 -9589
TP73 -4130 -5729
TRADD 7677 -7288
TRAF2 -7822 -10338
UACA 6252 1194
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UNC5A 8856 9670
UNC5B 5882 4196
VIM 10149 10565
XIAP 2637 2732
YWHAB 9116 6191
YWHAE 10079 10158
YWHAG 9489 10473
YWHAH 9385 9379
YWHAQ -6372 -2552
YWHAZ 7112 6341



Interleukin-1 family signaling

Interleukin-1 family signaling
metric value
setSize 124
pMANOVA 5.86e-13
p.adjustMANOVA 1.6e-11
s.dist 0.492
s.low.CRP 0.359
s.high.CRP 0.336
p.low.CRP 4.74e-12
p.high.CRP 9.59e-11




Top 20 genes
Gene low CRP high CRP
S100A12 10367 10617
IL1RN 10354 9802
APP 10085 9961
NKIRAS2 9577 10434
IRAK3 9582 10412
ALOX5 9735 9772
PSMD6 9864 9375
MAP2K1 8861 10365
PTPN2 8577 10537
CHUK 9608 9191
MAP2K6 8704 10103
NOD2 9289 9320
IL1R1 8837 9561
PSMB7 9346 8950
PSMA1 9165 8953
STAT3 9401 8593
PSME3 9544 8452
PSMD12 9648 8351
PSMD4 8627 9334
PSMD11 8697 9183

Click HERE to show all gene set members

All member genes
low CRP high CRP
AGER 1815 2573
ALOX5 9735 9772
APP 10085 9961
BTRC -7062 1812
CASP1 9611 2857
CHUK 9608 9191
CTSG 9668 2004
CUL1 7475 -10175
FBXW11 3233 8725
HMGB1 3409 1050
IKBKB -6356 -1160
IKBKG -595 7203
IL18 7946 10001
IL18BP -6907 -7996
IL18R1 -10208 2501
IL18RAP -10986 1316
IL1B 9843 323
IL1R1 8837 9561
IL1R2 7717 2515
IL1RAP -137 7646
IL1RL1 4851 -7621
IL1RN 10354 9802
IL33 -2225 -1120
IL4 -8327 -10394
IRAK1 2858 6473
IRAK2 -10838 -5931
IRAK3 9582 10412
MAP2K1 8861 10365
MAP2K4 5525 7430
MAP2K6 8704 10103
MAP3K3 6459 9695
MAP3K7 2469 7237
MAP3K8 -7148 10028
MAPK8 -794 -7374
MYD88 8926 8524
NFKB1 8527 5403
NFKB2 5450 -6553
NFKBIA 8114 5809
NFKBIB -5904 1139
NKIRAS1 1465 2281
NKIRAS2 9577 10434
NOD1 -10556 -9537
NOD2 9289 9320
PELI1 8918 5667
PELI2 7349 9515
PELI3 -320 9317
PSMA1 9165 8953
PSMA2 9175 6486
PSMA3 8811 -3545
PSMA4 8595 258
PSMA5 6009 -5256
PSMA6 9365 6915
PSMA7 6006 7700
PSMB1 8548 3242
PSMB10 -972 -8733
PSMB2 8065 5797
PSMB3 8817 8326
PSMB4 4018 3039
PSMB5 8225 9508
PSMB6 6959 8991
PSMB7 9346 8950
PSMB8 5148 -5793
PSMB9 -5133 -10716
PSMC1 7220 8544
PSMC2 4967 6378
PSMC3 2824 4673
PSMC4 -9365 -3210
PSMC5 2913 2050
PSMC6 9832 7978
PSMD1 8509 8974
PSMD10 6347 2957
PSMD11 8697 9183
PSMD12 9648 8351
PSMD13 7185 6511
PSMD14 7985 5632
PSMD2 7347 8049
PSMD3 3057 6067
PSMD4 8627 9334
PSMD5 1520 8328
PSMD6 9864 9375
PSMD7 9212 6772
PSMD8 6905 6585
PSMD9 7407 8869
PSME1 -1137 -9489
PSME2 3614 -10267
PSME3 9544 8452
PSME4 -8419 -464
PSMF1 7685 5740
PTPN11 3471 9688
PTPN12 6377 9874
PTPN13 -7614 -7223
PTPN14 -908 -488
PTPN18 -3234 9001
PTPN2 8577 10537
PTPN20 312 2477
PTPN23 -6746 561
PTPN4 -10744 -10485
PTPN6 3230 7923
PTPN7 -8688 -7879
PTPN9 -3258 9595
RBX1 1119 4750
RELA -2847 -1359
RIPK2 8675 2009
RPS27A -1868 -5386
S100A12 10367 10617
S100B -10129 814
SEM1 5210 6938
SIGIRR -8187 -8512
SKP1 8911 4204
SMAD3 -10166 -9199
SQSTM1 5451 -188
STAT3 9401 8593
TAB1 7080 3716
TAB2 8556 6836
TAB3 215 4794
TBK1 8071 5122
TNIP2 -929 4907
TOLLIP 8936 8482
TRAF6 -4471 1582
UBA52 2067 260
UBB 7788 3835
UBC 2562 2822
UBE2N 7813 4195
UBE2V1 8249 8108



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.2 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.0               GGally_2.1.1               
##  [3] beeswarm_0.3.1              gtools_3.8.2               
##  [5] echarts4r_0.4.0             topconfects_1.6.0          
##  [7] limma_3.46.0                eulerr_6.1.0               
##  [9] mitch_1.2.2                 MASS_7.3-53.1              
## [11] fgsea_1.16.0                gplots_3.1.1               
## [13] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [15] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [17] matrixStats_0.58.0          GenomicRanges_1.42.0       
## [19] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [21] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [23] reshape2_1.4.4              forcats_0.5.1              
## [25] stringr_1.4.0               dplyr_1.0.5                
## [27] purrr_0.3.4                 readr_1.4.0                
## [29] tidyr_1.1.3                 tibble_3.1.0               
## [31] ggplot2_3.3.3               tidyverse_1.3.0            
## [33] zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_2.0.2       
##   [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.13       
##   [7] farver_2.1.0           bit64_4.0.5            AnnotationDbi_1.52.0  
##  [10] fansi_0.4.2            lubridate_1.7.10       xml2_1.3.2            
##  [13] splines_4.0.3          cachem_1.0.4           geneplotter_1.68.0    
##  [16] knitr_1.31             polyclip_1.10-0        jsonlite_1.7.2        
##  [19] broom_0.7.5            annotate_1.68.0        dbplyr_2.1.0          
##  [22] shiny_1.6.0            compiler_4.0.3         httr_1.4.2            
##  [25] backports_1.2.1        assertthat_0.2.1       Matrix_1.3-2          
##  [28] fastmap_1.1.0          cli_2.3.1              later_1.1.0.1         
##  [31] htmltools_0.5.1.1      tools_4.0.3            gtable_0.3.0          
##  [34] glue_1.4.2             GenomeInfoDbData_1.2.4 fastmatch_1.1-0       
##  [37] Rcpp_1.0.6             cellranger_1.1.0       jquerylib_0.1.3       
##  [40] vctrs_0.3.6            polylabelr_0.2.0       xfun_0.22             
##  [43] ps_1.6.0               testthat_3.0.2         rvest_1.0.0           
##  [46] mime_0.10              lifecycle_1.0.0        XML_3.99-0.6          
##  [49] zlibbioc_1.36.0        scales_1.1.1           promises_1.2.0.1      
##  [52] hms_1.0.0              RColorBrewer_1.1-2     yaml_2.2.1            
##  [55] memoise_2.0.0          gridExtra_2.3          sass_0.3.1            
##  [58] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.4         
##  [61] highr_0.8              genefilter_1.72.0      desc_1.3.0            
##  [64] caTools_1.18.1         BiocParallel_1.24.1    rlang_0.4.10          
##  [67] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
##  [70] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.3     
##  [73] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
##  [76] magrittr_2.0.1         R6_2.5.0               generics_0.1.0        
##  [79] DelayedArray_0.16.0    DBI_1.1.1              pillar_1.5.1          
##  [82] haven_2.3.1            withr_2.4.1            survival_3.2-10       
##  [85] RCurl_1.98-1.3         modelr_0.1.8           crayon_1.4.1          
##  [88] KernSmooth_2.23-18     utf8_1.2.1             rmarkdown_2.7         
##  [91] locfit_1.5-9.4         grid_4.0.3             readxl_1.3.1          
##  [94] data.table_1.14.0      blob_1.2.1             reprex_1.0.0          
##  [97] digest_0.6.27          xtable_1.8-4           httpuv_1.5.5          
## [100] munsell_0.5.0          bslib_0.2.4

END of report