date generated: 2020-11-11

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             low CRP    high CRP
## A1BG      1.0864505  2.93660576
## A1BG-AS1  0.2363048  0.81097593
## A1CF      0.6265346  0.20979938
## A2M      -1.1565132 -4.19066691
## A2M-AS1  -1.1830767 -3.99635746
## A2ML1    -0.3033644 -0.09097114

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 21404
duplicated_genes_present 0
num_profile_genes_in_sets 8378
num_profile_genes_not_in_sets 13026
profile_pearson_correl 0.66054
profile_spearman_correl 0.61532

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2408
num_genesets_excluded 1045
num_genesets_included 1363

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 639

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.low.CRP s.high.CRP p.low.CRP p.high.CRP
IRAK4 deficiency (TLR2/4) 10 8.78e-07 8.31e-06 1.220 0.845 0.886 3.74e-06 1.20e-06
MyD88 deficiency (TLR2/4) 10 8.78e-07 8.31e-06 1.220 0.845 0.886 3.74e-06 1.20e-06
Regulation of TLR by endogenous ligand 11 1.12e-05 7.28e-05 1.050 0.770 0.720 9.70e-06 3.51e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 7.06e-06 4.81e-05 1.020 0.656 0.781 8.39e-05 2.80e-06
alpha-linolenic acid (ALA) metabolism 12 7.06e-06 4.81e-05 1.020 0.656 0.781 8.39e-05 2.80e-06
Translocation of ZAP-70 to Immunological synapse 24 7.25e-11 1.67e-09 1.020 -0.679 -0.759 8.22e-09 1.20e-10
Erythrocytes take up carbon dioxide and release oxygen 11 3.19e-05 1.76e-04 1.000 0.741 0.677 2.08e-05 1.02e-04
O2/CO2 exchange in erythrocytes 11 3.19e-05 1.76e-04 1.000 0.741 0.677 2.08e-05 1.02e-04
Hyaluronan uptake and degradation 12 3.64e-05 1.95e-04 0.941 0.591 0.732 3.93e-04 1.12e-05
Uptake and function of anthrax toxins 10 1.57e-04 7.16e-04 0.915 0.505 0.763 5.68e-03 2.93e-05
p130Cas linkage to MAPK signaling for integrins 11 2.21e-04 9.81e-04 0.908 0.649 0.635 1.94e-04 2.66e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.02e-04 4.96e-04 0.841 0.395 0.742 2.32e-02 2.01e-05
Unwinding of DNA 12 4.41e-04 1.81e-03 0.833 -0.582 -0.595 4.80e-04 3.55e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 4.56e-04 1.84e-03 0.823 0.627 0.533 1.71e-04 1.39e-03
RHO GTPases Activate WASPs and WAVEs 35 1.35e-10 3.02e-09 0.817 0.502 0.645 2.79e-07 4.06e-11
RNA Polymerase I Promoter Opening 19 4.75e-06 3.44e-05 0.814 0.499 0.643 1.63e-04 1.24e-06
Advanced glycosylation endproduct receptor signaling 12 2.24e-04 9.88e-04 0.809 0.432 0.683 9.49e-03 4.15e-05
PD-1 signaling 28 3.99e-08 5.28e-07 0.805 -0.535 -0.602 9.47e-07 3.51e-08
ROS and RNS production in phagocytes 31 1.32e-08 1.96e-07 0.793 0.577 0.545 2.73e-08 1.53e-07
Signaling by Leptin 10 2.94e-03 9.09e-03 0.789 0.587 0.527 1.31e-03 3.91e-03
Phosphorylation of CD3 and TCR zeta chains 27 2.11e-07 2.39e-06 0.783 -0.564 -0.542 3.81e-07 1.07e-06
Neutrophil degranulation 456 0.00e+00 0.00e+00 0.770 0.491 0.593 9.83e-73 0.00e+00
Insulin receptor recycling 21 1.06e-05 7.03e-05 0.766 0.535 0.549 2.22e-05 1.32e-05
MET activates RAP1 and RAC1 10 4.02e-03 1.20e-02 0.761 0.487 0.585 7.65e-03 1.37e-03
Dissolution of Fibrin Clot 12 1.84e-03 6.22e-03 0.752 0.531 0.533 1.45e-03 1.40e-03
RHO GTPases Activate NADPH Oxidases 21 1.52e-05 9.29e-05 0.733 0.442 0.584 4.58e-04 3.52e-06
COPI-independent Golgi-to-ER retrograde traffic 33 2.25e-08 3.13e-07 0.729 0.426 0.592 2.29e-05 4.03e-09
Detoxification of Reactive Oxygen Species 31 5.24e-08 6.67e-07 0.728 0.417 0.597 5.93e-05 8.44e-09
Diseases associated with the TLR signaling cascade 23 1.11e-05 7.23e-05 0.725 0.476 0.548 7.78e-05 5.43e-06
Diseases of Immune System 23 1.11e-05 7.23e-05 0.725 0.476 0.548 7.78e-05 5.43e-06
Platelet Adhesion to exposed collagen 13 1.31e-03 4.62e-03 0.724 0.572 0.443 3.56e-04 5.66e-03
Hyaluronan metabolism 15 8.47e-04 3.24e-03 0.702 0.446 0.543 2.80e-03 2.74e-04
EPHB-mediated forward signaling 32 4.26e-07 4.63e-06 0.702 0.482 0.511 2.40e-06 5.70e-07
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 3.92e-03 1.17e-02 0.699 0.346 0.607 5.78e-02 8.88e-04
IRAK1 recruits IKK complex 10 8.10e-03 2.14e-02 0.687 0.393 0.564 3.12e-02 2.02e-03
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 8.10e-03 2.14e-02 0.687 0.393 0.564 3.12e-02 2.02e-03
Retrograde neurotrophin signalling 12 5.84e-04 2.31e-03 0.682 0.269 0.626 1.06e-01 1.73e-04
Cargo concentration in the ER 30 1.44e-06 1.32e-05 0.681 0.423 0.534 6.09e-05 4.19e-07
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.58e-03 5.41e-03 0.679 0.399 0.549 9.69e-03 3.77e-04
GRB2 events in EGFR signaling 10 1.35e-02 3.26e-02 0.678 0.502 0.456 5.98e-03 1.25e-02
The NLRP3 inflammasome 15 1.50e-03 5.15e-03 0.677 0.515 0.439 5.56e-04 3.22e-03
Pentose phosphate pathway 13 3.27e-03 1.00e-02 0.677 0.425 0.526 7.94e-03 1.01e-03
Platelet sensitization by LDL 16 1.20e-04 5.68e-04 0.675 0.298 0.606 3.92e-02 2.69e-05
Transferrin endocytosis and recycling 26 1.93e-05 1.16e-04 0.670 0.457 0.489 5.48e-05 1.56e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 9.94e-04 3.65e-03 0.669 0.312 0.592 5.14e-02 2.19e-04
DNA methylation 20 1.38e-04 6.42e-04 0.668 0.395 0.539 2.21e-03 3.05e-05
RHO GTPases Activate ROCKs 18 8.93e-05 4.43e-04 0.663 0.313 0.585 2.13e-02 1.74e-05
Gap junction trafficking 13 8.55e-04 3.26e-03 0.660 0.288 0.594 7.20e-02 2.08e-04
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 20 1.74e-04 7.90e-04 0.660 0.392 0.531 2.42e-03 3.94e-05
Neurodegenerative Diseases 20 1.74e-04 7.90e-04 0.660 0.392 0.531 2.42e-03 3.94e-05


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.low.CRP s.high.CRP p.low.CRP p.high.CRP
IRAK4 deficiency (TLR2/4) 10 8.78e-07 8.31e-06 1.22000 0.845000 8.86e-01 3.74e-06 1.20e-06
MyD88 deficiency (TLR2/4) 10 8.78e-07 8.31e-06 1.22000 0.845000 8.86e-01 3.74e-06 1.20e-06
Regulation of TLR by endogenous ligand 11 1.12e-05 7.28e-05 1.05000 0.770000 7.20e-01 9.70e-06 3.51e-05
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 7.06e-06 4.81e-05 1.02000 0.656000 7.81e-01 8.39e-05 2.80e-06
alpha-linolenic acid (ALA) metabolism 12 7.06e-06 4.81e-05 1.02000 0.656000 7.81e-01 8.39e-05 2.80e-06
Translocation of ZAP-70 to Immunological synapse 24 7.25e-11 1.67e-09 1.02000 -0.679000 -7.59e-01 8.22e-09 1.20e-10
Erythrocytes take up carbon dioxide and release oxygen 11 3.19e-05 1.76e-04 1.00000 0.741000 6.77e-01 2.08e-05 1.02e-04
O2/CO2 exchange in erythrocytes 11 3.19e-05 1.76e-04 1.00000 0.741000 6.77e-01 2.08e-05 1.02e-04
Hyaluronan uptake and degradation 12 3.64e-05 1.95e-04 0.94100 0.591000 7.32e-01 3.93e-04 1.12e-05
Uptake and function of anthrax toxins 10 1.57e-04 7.16e-04 0.91500 0.505000 7.63e-01 5.68e-03 2.93e-05
p130Cas linkage to MAPK signaling for integrins 11 2.21e-04 9.81e-04 0.90800 0.649000 6.35e-01 1.94e-04 2.66e-04
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.02e-04 4.96e-04 0.84100 0.395000 7.42e-01 2.32e-02 2.01e-05
Unwinding of DNA 12 4.41e-04 1.81e-03 0.83300 -0.582000 -5.95e-01 4.80e-04 3.55e-04
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 4.56e-04 1.84e-03 0.82300 0.627000 5.33e-01 1.71e-04 1.39e-03
RHO GTPases Activate WASPs and WAVEs 35 1.35e-10 3.02e-09 0.81700 0.502000 6.45e-01 2.79e-07 4.06e-11
RNA Polymerase I Promoter Opening 19 4.75e-06 3.44e-05 0.81400 0.499000 6.43e-01 1.63e-04 1.24e-06
Advanced glycosylation endproduct receptor signaling 12 2.24e-04 9.88e-04 0.80900 0.432000 6.83e-01 9.49e-03 4.15e-05
PD-1 signaling 28 3.99e-08 5.28e-07 0.80500 -0.535000 -6.02e-01 9.47e-07 3.51e-08
ROS and RNS production in phagocytes 31 1.32e-08 1.96e-07 0.79300 0.577000 5.45e-01 2.73e-08 1.53e-07
Signaling by Leptin 10 2.94e-03 9.09e-03 0.78900 0.587000 5.27e-01 1.31e-03 3.91e-03
Phosphorylation of CD3 and TCR zeta chains 27 2.11e-07 2.39e-06 0.78300 -0.564000 -5.42e-01 3.81e-07 1.07e-06
Neutrophil degranulation 456 1.26e-111 1.72e-108 0.77000 0.491000 5.93e-01 9.83e-73 2.07e-105
Insulin receptor recycling 21 1.06e-05 7.03e-05 0.76600 0.535000 5.49e-01 2.22e-05 1.32e-05
MET activates RAP1 and RAC1 10 4.02e-03 1.20e-02 0.76100 0.487000 5.85e-01 7.65e-03 1.37e-03
Dissolution of Fibrin Clot 12 1.84e-03 6.22e-03 0.75200 0.531000 5.33e-01 1.45e-03 1.40e-03
RHO GTPases Activate NADPH Oxidases 21 1.52e-05 9.29e-05 0.73300 0.442000 5.84e-01 4.58e-04 3.52e-06
COPI-independent Golgi-to-ER retrograde traffic 33 2.25e-08 3.13e-07 0.72900 0.426000 5.92e-01 2.29e-05 4.03e-09
Detoxification of Reactive Oxygen Species 31 5.24e-08 6.67e-07 0.72800 0.417000 5.97e-01 5.93e-05 8.44e-09
Diseases associated with the TLR signaling cascade 23 1.11e-05 7.23e-05 0.72500 0.476000 5.48e-01 7.78e-05 5.43e-06
Diseases of Immune System 23 1.11e-05 7.23e-05 0.72500 0.476000 5.48e-01 7.78e-05 5.43e-06
Platelet Adhesion to exposed collagen 13 1.31e-03 4.62e-03 0.72400 0.572000 4.43e-01 3.56e-04 5.66e-03
Hyaluronan metabolism 15 8.47e-04 3.24e-03 0.70200 0.446000 5.43e-01 2.80e-03 2.74e-04
EPHB-mediated forward signaling 32 4.26e-07 4.63e-06 0.70200 0.482000 5.11e-01 2.40e-06 5.70e-07
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 3.92e-03 1.17e-02 0.69900 0.346000 6.07e-01 5.78e-02 8.88e-04
IRAK1 recruits IKK complex 10 8.10e-03 2.14e-02 0.68700 0.393000 5.64e-01 3.12e-02 2.02e-03
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 8.10e-03 2.14e-02 0.68700 0.393000 5.64e-01 3.12e-02 2.02e-03
Retrograde neurotrophin signalling 12 5.84e-04 2.31e-03 0.68200 0.269000 6.26e-01 1.06e-01 1.73e-04
Cargo concentration in the ER 30 1.44e-06 1.32e-05 0.68100 0.423000 5.34e-01 6.09e-05 4.19e-07
Golgi Cisternae Pericentriolar Stack Reorganization 14 1.58e-03 5.41e-03 0.67900 0.399000 5.49e-01 9.69e-03 3.77e-04
GRB2 events in EGFR signaling 10 1.35e-02 3.26e-02 0.67800 0.502000 4.56e-01 5.98e-03 1.25e-02
The NLRP3 inflammasome 15 1.50e-03 5.15e-03 0.67700 0.515000 4.39e-01 5.56e-04 3.22e-03
Pentose phosphate pathway 13 3.27e-03 1.00e-02 0.67700 0.425000 5.26e-01 7.94e-03 1.01e-03
Platelet sensitization by LDL 16 1.20e-04 5.68e-04 0.67500 0.298000 6.06e-01 3.92e-02 2.69e-05
Transferrin endocytosis and recycling 26 1.93e-05 1.16e-04 0.67000 0.457000 4.89e-01 5.48e-05 1.56e-05
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 9.94e-04 3.65e-03 0.66900 0.312000 5.92e-01 5.14e-02 2.19e-04
DNA methylation 20 1.38e-04 6.42e-04 0.66800 0.395000 5.39e-01 2.21e-03 3.05e-05
RHO GTPases Activate ROCKs 18 8.93e-05 4.43e-04 0.66300 0.313000 5.85e-01 2.13e-02 1.74e-05
Gap junction trafficking 13 8.55e-04 3.26e-03 0.66000 0.288000 5.94e-01 7.20e-02 2.08e-04
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 20 1.74e-04 7.90e-04 0.66000 0.392000 5.31e-01 2.42e-03 3.94e-05
Neurodegenerative Diseases 20 1.74e-04 7.90e-04 0.66000 0.392000 5.31e-01 2.42e-03 3.94e-05
InlB-mediated entry of Listeria monocytogenes into host cell 12 5.70e-03 1.60e-02 0.65800 0.390000 5.30e-01 1.94e-02 1.48e-03
Budding and maturation of HIV virion 26 4.82e-06 3.46e-05 0.65100 0.331000 5.60e-01 3.46e-03 7.57e-07
Smooth Muscle Contraction 30 2.63e-06 2.12e-05 0.64800 0.371000 5.32e-01 4.36e-04 4.62e-07
Negative regulation of MET activity 18 4.86e-04 1.96e-03 0.64700 0.374000 5.28e-01 6.04e-03 1.05e-04
MAP2K and MAPK activation 34 5.69e-07 5.88e-06 0.64700 0.374000 5.27e-01 1.57e-04 1.01e-07
VLDLR internalisation and degradation 11 1.28e-04 6.00e-04 0.64200 0.095400 6.35e-01 5.84e-01 2.66e-04
Endosomal Sorting Complex Required For Transport (ESCRT) 29 2.76e-06 2.20e-05 0.64000 0.339000 5.43e-01 1.56e-03 4.21e-07
SHC1 events in EGFR signaling 11 1.54e-02 3.56e-02 0.63800 0.432000 4.69e-01 1.30e-02 7.07e-03
Inflammasomes 20 1.93e-04 8.69e-04 0.63800 0.533000 3.49e-01 3.62e-05 6.81e-03
Generation of second messenger molecules 38 4.43e-07 4.68e-06 0.63600 -0.406000 -4.89e-01 1.45e-05 1.82e-07
DNA strand elongation 32 3.38e-06 2.65e-05 0.63100 -0.377000 -5.06e-01 2.23e-04 7.32e-07
ATF6 (ATF6-alpha) activates chaperone genes 10 2.29e-02 4.89e-02 0.63100 0.482000 4.06e-01 8.26e-03 2.62e-02
Butyrophilin (BTN) family interactions 10 2.38e-02 5.06e-02 0.63000 -0.475000 -4.13e-01 9.24e-03 2.37e-02
Signaling by high-kinase activity BRAF mutants 31 5.20e-06 3.65e-05 0.63000 0.376000 5.05e-01 2.88e-04 1.13e-06
Signal amplification 28 3.40e-05 1.84e-04 0.62700 0.464000 4.22e-01 2.16e-05 1.09e-04
Antimicrobial peptides 33 2.72e-06 2.18e-05 0.62600 0.503000 3.73e-01 5.78e-07 2.08e-04
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 1.02e-04 4.96e-04 0.62400 0.333000 5.28e-01 6.91e-03 1.82e-05
Prolonged ERK activation events 13 6.00e-03 1.67e-02 0.62100 0.354000 5.10e-01 2.70e-02 1.46e-03
RHO GTPases activate PKNs 47 4.15e-09 6.57e-08 0.62000 0.332000 5.23e-01 8.24e-05 5.25e-10
Mucopolysaccharidoses 11 6.64e-03 1.82e-02 0.61500 0.282000 5.47e-01 1.06e-01 1.68e-03
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 1.45e-02 3.43e-02 0.61500 0.416000 4.53e-01 1.26e-02 6.64e-03
Diseases of hemostasis 12 1.45e-02 3.43e-02 0.61500 0.416000 4.53e-01 1.26e-02 6.64e-03
HuR (ELAVL1) binds and stabilizes mRNA 10 2.24e-02 4.83e-02 0.61400 0.499000 3.57e-01 6.26e-03 5.08e-02
Metabolism of Angiotensinogen to Angiotensins 11 8.86e-03 2.29e-02 0.61200 0.534000 3.00e-01 2.16e-03 8.52e-02
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 5.03e-03 1.44e-02 0.60900 0.390000 4.68e-01 8.96e-03 1.72e-03
Amyloid fiber formation 51 1.27e-08 1.90e-07 0.60300 0.365000 4.80e-01 6.35e-06 3.05e-09
RHO GTPases activate IQGAPs 11 1.38e-02 3.31e-02 0.60200 0.321000 5.09e-01 6.52e-02 3.43e-03
Response to elevated platelet cytosolic Ca2+ 108 8.50e-17 6.44e-15 0.59900 0.380000 4.63e-01 9.02e-12 8.21e-17
Platelet degranulation 104 4.56e-16 3.11e-14 0.59800 0.383000 4.59e-01 1.42e-11 5.60e-16
Signal transduction by L1 20 5.68e-04 2.26e-03 0.59300 0.320000 4.99e-01 1.31e-02 1.12e-04
Interleukin-6 signaling 10 3.79e-02 7.45e-02 0.59200 0.437000 4.00e-01 1.68e-02 2.85e-02
Spry regulation of FGF signaling 16 1.29e-03 4.55e-03 0.59200 0.276000 5.23e-01 5.63e-02 2.88e-04
ADP signalling through P2Y purinoceptor 1 21 9.98e-04 3.65e-03 0.59100 0.445000 3.90e-01 4.16e-04 1.99e-03
Signaling by RAF1 mutants 34 7.43e-06 5.01e-05 0.58900 0.345000 4.77e-01 4.96e-04 1.47e-06
RHO GTPases activate PAKs 20 1.98e-04 8.89e-04 0.58700 0.260000 5.27e-01 4.44e-02 4.49e-05
Activation of the AP-1 family of transcription factors 10 3.73e-02 7.36e-02 0.58600 0.454000 3.70e-01 1.29e-02 4.29e-02
ATF6 (ATF6-alpha) activates chaperones 12 2.07e-02 4.49e-02 0.58500 0.442000 3.85e-01 8.08e-03 2.11e-02
activated TAK1 mediates p38 MAPK activation 19 9.67e-04 3.58e-03 0.58100 0.306000 4.94e-01 2.09e-02 1.95e-04
Erythropoietin activates RAS 13 1.50e-02 3.50e-02 0.57800 0.360000 4.52e-01 2.45e-02 4.74e-03
WNT5A-dependent internalization of FZD4 13 9.68e-04 3.58e-03 0.57800 0.165000 5.54e-01 3.02e-01 5.46e-04
Platelet Aggregation (Plug Formation) 28 7.19e-05 3.63e-04 0.57500 0.325000 4.75e-01 2.93e-03 1.35e-05
Activation of the pre-replicative complex 32 1.67e-05 1.01e-04 0.57500 -0.321000 -4.78e-01 1.69e-03 2.89e-06
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.48e-02 3.47e-02 0.57400 0.276000 5.04e-01 1.13e-01 3.83e-03
EGFR downregulation 26 1.85e-05 1.12e-04 0.57200 0.240000 5.19e-01 3.39e-02 4.58e-06
Transcriptional regulation of granulopoiesis 46 9.38e-07 8.75e-06 0.57100 0.403000 4.04e-01 2.21e-06 2.18e-06
Packaging Of Telomere Ends 20 8.41e-04 3.23e-03 0.56900 0.297000 4.86e-01 2.16e-02 1.68e-04
HDR through MMEJ (alt-NHEJ) 10 4.95e-02 9.41e-02 0.56700 -0.383000 -4.19e-01 3.62e-02 2.19e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 5.35e-14 1.97e-12 0.56600 0.315000 4.70e-01 1.75e-07 6.24e-15
Toll Like Receptor 2 (TLR2) Cascade 92 5.35e-14 1.97e-12 0.56600 0.315000 4.70e-01 1.75e-07 6.24e-15
Toll Like Receptor TLR1:TLR2 Cascade 92 5.35e-14 1.97e-12 0.56600 0.315000 4.70e-01 1.75e-07 6.24e-15
Toll Like Receptor TLR6:TLR2 Cascade 92 5.35e-14 1.97e-12 0.56600 0.315000 4.70e-01 1.75e-07 6.24e-15
ADP signalling through P2Y purinoceptor 12 18 3.60e-03 1.09e-02 0.56500 0.449000 3.43e-01 9.80e-04 1.18e-02
Thromboxane signalling through TP receptor 20 2.32e-03 7.29e-03 0.56300 0.436000 3.56e-01 7.37e-04 5.86e-03
Interleukin-1 signaling 97 1.45e-14 6.57e-13 0.56100 0.309000 4.68e-01 1.50e-07 1.57e-15
G beta:gamma signalling through CDC42 17 5.40e-03 1.53e-02 0.55500 0.448000 3.28e-01 1.39e-03 1.90e-02
Alpha-protein kinase 1 signaling pathway 11 4.15e-02 8.07e-02 0.55500 0.368000 4.16e-01 3.48e-02 1.70e-02
GAB1 signalosome 14 7.36e-03 1.97e-02 0.55500 0.273000 4.83e-01 7.65e-02 1.76e-03
Trafficking of GluR2-containing AMPA receptors 12 4.83e-03 1.39e-02 0.55400 0.191000 5.19e-01 2.52e-01 1.83e-03
Response of Mtb to phagocytosis 22 8.56e-04 3.26e-03 0.55300 0.304000 4.62e-01 1.36e-02 1.75e-04
RHO GTPases activate KTN1 11 4.42e-02 8.51e-02 0.55100 0.375000 4.05e-01 3.14e-02 2.01e-02
Josephin domain DUBs 10 2.85e-02 5.91e-02 0.55100 0.262000 4.85e-01 1.51e-01 7.91e-03
Cell recruitment (pro-inflammatory response) 22 1.08e-03 3.92e-03 0.55100 0.453000 3.13e-01 2.35e-04 1.10e-02
Purinergic signaling in leishmaniasis infection 22 1.08e-03 3.92e-03 0.55100 0.453000 3.13e-01 2.35e-04 1.10e-02
Activation of ATR in response to replication stress 36 1.08e-05 7.09e-05 0.55000 -0.301000 -4.60e-01 1.78e-03 1.78e-06
mTORC1-mediated signalling 24 1.23e-03 4.36e-03 0.54900 0.384000 3.92e-01 1.13e-03 8.90e-04
Regulated proteolysis of p75NTR 11 8.94e-03 2.31e-02 0.54700 0.194000 5.12e-01 2.66e-01 3.27e-03
Integrin signaling 22 9.18e-04 3.45e-03 0.54700 0.296000 4.60e-01 1.62e-02 1.86e-04
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 1.15e-05 7.30e-05 0.54500 0.316000 4.44e-01 7.37e-04 2.20e-06
Signaling by RAS mutants 38 1.15e-05 7.30e-05 0.54500 0.316000 4.44e-01 7.37e-04 2.20e-06
Signaling by moderate kinase activity BRAF mutants 38 1.15e-05 7.30e-05 0.54500 0.316000 4.44e-01 7.37e-04 2.20e-06
Signaling downstream of RAS mutants 38 1.15e-05 7.30e-05 0.54500 0.316000 4.44e-01 7.37e-04 2.20e-06
ERKs are inactivated 13 1.09e-03 3.94e-03 0.54500 0.121000 5.31e-01 4.49e-01 9.15e-04
Signal regulatory protein family interactions 12 3.54e-02 7.05e-02 0.54400 0.360000 4.08e-01 3.08e-02 1.43e-02
Formation of ATP by chemiosmotic coupling 18 1.89e-03 6.36e-03 0.54300 0.255000 4.79e-01 6.12e-02 4.28e-04
AKT phosphorylates targets in the cytosol 14 2.16e-03 7.02e-03 0.54100 0.176000 5.11e-01 2.54e-01 9.21e-04
Response of EIF2AK1 (HRI) to heme deficiency 14 1.62e-02 3.72e-02 0.54100 0.439000 3.15e-01 4.41e-03 4.15e-02
Collagen degradation 28 3.55e-04 1.49e-03 0.54000 0.331000 4.26e-01 2.45e-03 9.41e-05
EPH-Ephrin signaling 78 1.61e-10 3.53e-09 0.53700 0.315000 4.36e-01 1.52e-06 2.84e-11
Late endosomal microautophagy 29 1.23e-04 5.81e-04 0.53700 0.286000 4.55e-01 7.78e-03 2.21e-05
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 3.38e-04 1.43e-03 0.53600 0.380000 3.78e-01 3.17e-04 3.37e-04
Infection with Mycobacterium tuberculosis 26 4.34e-04 1.78e-03 0.53500 0.297000 4.45e-01 8.74e-03 8.63e-05
Formation of apoptosome 11 5.18e-02 9.78e-02 0.53400 0.351000 4.03e-01 4.39e-02 2.06e-02
Regulation of the apoptosome activity 11 5.18e-02 9.78e-02 0.53400 0.351000 4.03e-01 4.39e-02 2.06e-02
Translation of Replicase and Assembly of the Replication Transcription Complex 12 3.98e-02 7.79e-02 0.53100 0.341000 4.07e-01 4.06e-02 1.46e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 3.45e-05 1.86e-04 0.53100 0.308000 4.33e-01 1.41e-03 6.76e-06
Sealing of the nuclear envelope (NE) by ESCRT-III 25 3.17e-05 1.76e-04 0.52800 0.175000 4.98e-01 1.31e-01 1.60e-05
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 87 1.44e-11 3.71e-10 0.52700 0.295000 4.37e-01 2.02e-06 1.85e-12
Glycogen breakdown (glycogenolysis) 13 1.78e-02 3.97e-02 0.52600 0.265000 4.54e-01 9.75e-02 4.56e-03
Growth hormone receptor signaling 20 6.20e-03 1.71e-02 0.52300 0.361000 3.78e-01 5.17e-03 3.41e-03
SUMOylation of immune response proteins 11 7.14e-03 1.94e-02 0.52200 0.139000 5.03e-01 4.25e-01 3.88e-03
Pre-NOTCH Processing in Golgi 18 2.80e-05 1.61e-04 0.52200 0.047900 5.19e-01 7.25e-01 1.36e-04
Frs2-mediated activation 11 3.70e-02 7.32e-02 0.52100 0.269000 4.47e-01 1.23e-01 1.03e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 1.30e-11 3.47e-10 0.52100 0.290000 4.33e-01 2.18e-06 1.63e-12
Lagging Strand Synthesis 20 2.17e-03 7.03e-03 0.51800 -0.254000 -4.51e-01 4.97e-02 4.74e-04
Membrane binding and targetting of GAG proteins 13 1.40e-02 3.34e-02 0.51700 0.231000 4.63e-01 1.50e-01 3.85e-03
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 1.40e-02 3.34e-02 0.51700 0.231000 4.63e-01 1.50e-01 3.85e-03
Suppression of phagosomal maturation 12 7.24e-03 1.95e-02 0.51700 0.161000 4.92e-01 3.35e-01 3.19e-03
Iron uptake and transport 52 2.37e-06 1.95e-05 0.51600 0.385000 3.43e-01 1.57e-06 1.84e-05
MyD88 dependent cascade initiated on endosome 88 3.62e-11 8.80e-10 0.51200 0.282000 4.27e-01 4.63e-06 4.44e-12
Cross-presentation of soluble exogenous antigens (endosomes) 47 1.71e-06 1.52e-05 0.51100 0.269000 4.34e-01 1.42e-03 2.56e-07
Toll Like Receptor 4 (TLR4) Cascade 121 5.54e-15 2.90e-13 0.51100 0.283000 4.25e-01 7.62e-08 6.13e-16
G beta:gamma signalling through PLC beta 17 1.49e-02 3.48e-02 0.50900 0.393000 3.24e-01 5.06e-03 2.07e-02
Presynaptic function of Kainate receptors 17 1.49e-02 3.48e-02 0.50900 0.393000 3.24e-01 5.06e-03 2.07e-02
Antigen processing-Cross presentation 97 7.58e-13 2.40e-11 0.50900 0.258000 4.38e-01 1.08e-05 8.20e-14
Regulation of IFNG signaling 14 1.74e-02 3.92e-02 0.50800 0.255000 4.39e-01 9.85e-02 4.47e-03
Signaling by BRAF and RAF fusions 57 9.29e-07 8.73e-06 0.50700 0.328000 3.87e-01 1.84e-05 4.28e-07
Recycling pathway of L1 26 6.08e-05 3.13e-04 0.50700 0.174000 4.76e-01 1.24e-01 2.65e-05
Regulation of ornithine decarboxylase (ODC) 49 2.32e-06 1.93e-05 0.50700 0.285000 4.19e-01 5.52e-04 3.84e-07
MyD88 cascade initiated on plasma membrane 82 1.85e-10 3.89e-09 0.50600 0.271000 4.27e-01 2.15e-05 2.19e-11
Toll Like Receptor 10 (TLR10) Cascade 82 1.85e-10 3.89e-09 0.50600 0.271000 4.27e-01 2.15e-05 2.19e-11
Toll Like Receptor 5 (TLR5) Cascade 82 1.85e-10 3.89e-09 0.50600 0.271000 4.27e-01 2.15e-05 2.19e-11
Heme degradation 10 6.30e-02 1.15e-01 0.50600 0.267000 4.29e-01 1.43e-01 1.87e-02
Biotin transport and metabolism 11 7.30e-02 1.30e-01 0.50500 -0.370000 -3.44e-01 3.36e-02 4.81e-02
Assembly Of The HIV Virion 15 7.55e-03 2.02e-02 0.50500 0.212000 4.58e-01 1.54e-01 2.14e-03
COPI-mediated anterograde transport 78 2.53e-10 5.18e-09 0.50400 0.255000 4.35e-01 9.81e-05 3.06e-11
G beta:gamma signalling through BTK 15 2.31e-02 4.93e-02 0.50400 0.404000 3.01e-01 6.74e-03 4.38e-02
Energy dependent regulation of mTOR by LKB1-AMPK 27 6.57e-04 2.57e-03 0.50300 0.269000 4.26e-01 1.57e-02 1.29e-04
Lysosome Vesicle Biogenesis 32 1.86e-04 8.38e-04 0.50200 0.270000 4.23e-01 8.18e-03 3.42e-05
DARPP-32 events 22 1.24e-03 4.38e-03 0.50100 0.228000 4.47e-01 6.45e-02 2.87e-04
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 2.09e-03 6.90e-03 0.50100 -0.285000 -4.12e-01 1.58e-02 4.70e-04
Toll Like Receptor 9 (TLR9) Cascade 92 5.72e-11 1.34e-09 0.49900 0.280000 4.13e-01 3.48e-06 7.57e-12
Signalling to ERKs 31 5.93e-04 2.33e-03 0.49900 0.311000 3.90e-01 2.72e-03 1.73e-04
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 53 6.09e-07 6.05e-06 0.49800 0.259000 4.25e-01 1.09e-03 8.79e-08
Notch-HLH transcription pathway 28 2.62e-04 1.14e-03 0.49700 0.231000 4.40e-01 3.44e-02 5.46e-05
Toll-like Receptor Cascades 143 4.51e-16 3.11e-14 0.49500 0.286000 4.04e-01 3.68e-09 6.79e-17
Cellular response to hypoxia 71 1.53e-09 2.64e-08 0.49300 0.233000 4.35e-01 6.98e-04 2.31e-10
COPII-mediated vesicle transport 65 2.79e-08 3.81e-07 0.49300 0.254000 4.23e-01 4.00e-04 3.70e-09
G-protein beta:gamma signalling 29 7.26e-04 2.83e-03 0.49200 0.277000 4.06e-01 9.91e-03 1.51e-04
Common Pathway of Fibrin Clot Formation 14 3.29e-02 6.64e-02 0.49000 0.282000 4.01e-01 6.79e-02 9.40e-03
Thrombin signalling through proteinase activated receptors (PARs) 27 2.29e-03 7.24e-03 0.48900 0.320000 3.69e-01 4.00e-03 8.92e-04
Apoptosis induced DNA fragmentation 10 7.03e-02 1.26e-01 0.48800 0.248000 4.21e-01 1.74e-01 2.13e-02
ERK/MAPK targets 22 1.23e-03 4.36e-03 0.48800 0.205000 4.43e-01 9.63e-02 3.25e-04
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 2.63e-02 5.52e-02 0.48700 0.308000 3.78e-01 3.31e-02 8.92e-03
Innate Immune System 963 6.13e-91 4.18e-88 0.48700 0.319000 3.68e-01 1.70e-63 7.54e-84
Processive synthesis on the lagging strand 15 1.12e-02 2.79e-02 0.48600 -0.207000 -4.40e-01 1.65e-01 3.20e-03
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.12e-02 6.37e-02 0.48500 0.265000 4.06e-01 8.56e-02 8.53e-03
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 3.81e-06 2.92e-05 0.48500 0.248000 4.17e-01 2.90e-03 5.90e-07
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 1.86e-02 4.11e-02 0.48500 0.149000 4.61e-01 3.92e-01 8.10e-03
MTOR signalling 39 1.11e-04 5.35e-04 0.48400 0.285000 3.91e-01 2.05e-03 2.41e-05
Cytochrome c-mediated apoptotic response 13 5.96e-02 1.09e-01 0.48300 0.333000 3.50e-01 3.78e-02 2.89e-02
Glycogen synthesis 13 3.61e-02 7.17e-02 0.48300 0.251000 4.13e-01 1.18e-01 9.95e-03
Beta-catenin phosphorylation cascade 17 4.40e-03 1.28e-02 0.48200 0.182000 4.46e-01 1.94e-01 1.44e-03
Syndecan interactions 19 1.44e-02 3.41e-02 0.48200 0.375000 3.03e-01 4.68e-03 2.23e-02
Gap junction trafficking and regulation 15 1.28e-02 3.11e-02 0.48000 0.207000 4.34e-01 1.65e-01 3.64e-03
ER to Golgi Anterograde Transport 129 4.52e-15 2.51e-13 0.48000 0.242000 4.14e-01 1.99e-06 4.59e-16
Defective CFTR causes cystic fibrosis 58 2.79e-07 3.15e-06 0.47800 0.235000 4.16e-01 2.00e-03 4.20e-08
trans-Golgi Network Vesicle Budding 69 2.75e-08 3.79e-07 0.47700 0.243000 4.10e-01 4.71e-04 3.67e-09
G-protein activation 23 6.57e-03 1.80e-02 0.47700 0.371000 2.99e-01 2.06e-03 1.30e-02
Sema4D in semaphorin signaling 22 3.76e-04 1.56e-03 0.47500 0.138000 4.55e-01 2.64e-01 2.23e-04
Formation of the cornified envelope 21 1.08e-02 2.73e-02 0.47400 0.368000 2.99e-01 3.53e-03 1.77e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 2.28e-06 1.90e-05 0.47300 0.246000 4.05e-01 1.96e-03 3.44e-07
Telomere C-strand (Lagging Strand) Synthesis 34 6.69e-04 2.61e-03 0.47300 -0.297000 -3.68e-01 2.70e-03 2.04e-04
LDL clearance 17 2.71e-02 5.66e-02 0.47300 0.305000 3.61e-01 2.95e-02 9.86e-03
HDACs deacetylate histones 47 2.10e-06 1.78e-05 0.47300 0.206000 4.25e-01 1.45e-02 4.54e-07
Pyrimidine salvage 10 8.77e-02 1.52e-01 0.47200 0.247000 4.03e-01 1.77e-01 2.74e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 2.11e-03 6.95e-03 0.47200 0.204000 4.26e-01 9.81e-02 5.43e-04
Calnexin/calreticulin cycle 26 1.01e-03 3.68e-03 0.47200 0.219000 4.18e-01 5.33e-02 2.25e-04
Telomere C-strand synthesis initiation 13 6.78e-02 1.22e-01 0.47200 -0.343000 -3.24e-01 3.23e-02 4.30e-02
Hh mutants abrogate ligand secretion 54 2.00e-06 1.73e-05 0.47100 0.245000 4.03e-01 1.86e-03 3.01e-07
MET activates RAS signaling 10 1.24e-01 1.99e-01 0.47100 0.355000 3.10e-01 5.19e-02 8.98e-02
IKK complex recruitment mediated by RIP1 23 6.89e-03 1.88e-02 0.46900 0.284000 3.74e-01 1.84e-02 1.91e-03
ER-Phagosome pathway 82 5.95e-10 1.05e-08 0.46900 0.221000 4.14e-01 5.53e-04 9.00e-11
Sema4D induced cell migration and growth-cone collapse 19 2.65e-03 8.20e-03 0.46800 0.167000 4.38e-01 2.08e-01 9.58e-04
Signaling by Erythropoietin 24 1.78e-03 6.04e-03 0.46800 0.213000 4.16e-01 7.02e-02 4.18e-04
RUNX1 regulates transcription of genes involved in differentiation of HSCs 82 6.85e-09 1.06e-07 0.46700 0.254000 3.91e-01 6.84e-05 9.03e-10
Activation of G protein gated Potassium channels 20 1.03e-02 2.61e-02 0.46700 0.390000 2.56e-01 2.51e-03 4.79e-02
G protein gated Potassium channels 20 1.03e-02 2.61e-02 0.46700 0.390000 2.56e-01 2.51e-03 4.79e-02
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 20 1.03e-02 2.61e-02 0.46700 0.390000 2.56e-01 2.51e-03 4.79e-02
Golgi Associated Vesicle Biogenesis 55 4.03e-06 3.04e-05 0.46600 0.260000 3.87e-01 8.66e-04 6.62e-07
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 9.91e-08 1.18e-06 0.46600 0.223000 4.09e-01 2.03e-03 1.54e-08
Cell-extracellular matrix interactions 14 4.95e-02 9.41e-02 0.46500 0.276000 3.74e-01 7.33e-02 1.54e-02
Platelet activation, signaling and aggregation 219 2.66e-22 3.30e-20 0.46500 0.252000 3.90e-01 1.25e-10 2.28e-23
Signaling by MET 60 4.00e-06 3.03e-05 0.46300 0.287000 3.63e-01 1.19e-04 1.14e-06
PCNA-Dependent Long Patch Base Excision Repair 21 6.84e-03 1.87e-02 0.46300 -0.237000 -3.98e-01 6.05e-02 1.60e-03
Regulation of Apoptosis 51 9.67e-06 6.43e-05 0.46200 0.249000 3.89e-01 2.09e-03 1.56e-06
GP1b-IX-V activation signalling 10 1.32e-01 2.10e-01 0.46200 0.297000 3.54e-01 1.04e-01 5.28e-02
Post-translational protein phosphorylation 68 4.25e-07 4.63e-06 0.46100 0.264000 3.78e-01 1.62e-04 7.22e-08
Hedgehog ligand biogenesis 58 1.59e-06 1.43e-05 0.46100 0.242000 3.92e-01 1.43e-03 2.38e-07
MAP kinase activation 63 3.08e-07 3.44e-06 0.46100 0.231000 3.98e-01 1.51e-03 4.49e-08
RAB geranylgeranylation 61 1.95e-06 1.70e-05 0.46100 0.264000 3.77e-01 3.62e-04 3.41e-07
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 1.43e-03 4.97e-03 0.46000 0.226000 4.01e-01 4.24e-02 3.06e-04
Glucagon signaling in metabolic regulation 27 4.50e-03 1.31e-02 0.46000 0.298000 3.50e-01 7.36e-03 1.64e-03
PKA activation in glucagon signalling 14 2.06e-02 4.47e-02 0.46000 0.186000 4.20e-01 2.28e-01 6.47e-03
Interleukin-1 family signaling 124 4.75e-13 1.54e-11 0.45900 0.240000 3.91e-01 4.08e-06 4.94e-14
Vif-mediated degradation of APOBEC3G 52 6.37e-06 4.43e-05 0.45700 0.234000 3.92e-01 3.47e-03 1.01e-06
Degradation of GLI2 by the proteasome 56 3.79e-06 2.92e-05 0.45600 0.243000 3.86e-01 1.62e-03 5.86e-07
GLI3 is processed to GLI3R by the proteasome 56 3.79e-06 2.92e-05 0.45600 0.243000 3.86e-01 1.62e-03 5.86e-07
Signaling by cytosolic FGFR1 fusion mutants 17 3.54e-02 7.05e-02 0.45600 0.347000 2.95e-01 1.33e-02 3.50e-02
RHO GTPases activate CIT 18 1.61e-03 5.48e-03 0.45500 0.109000 4.42e-01 4.24e-01 1.16e-03
Activation of Matrix Metalloproteinases 23 8.98e-03 2.31e-02 0.45500 0.365000 2.73e-01 2.47e-03 2.36e-02
Degradation of DVL 54 2.36e-06 1.95e-05 0.45500 0.219000 3.99e-01 5.32e-03 3.92e-07
RAF activation 32 3.57e-04 1.49e-03 0.45500 0.210000 4.04e-01 4.01e-02 7.66e-05
Signaling by NTRKs 114 2.13e-11 5.28e-10 0.45400 0.250000 3.79e-01 3.88e-06 2.57e-12
Negative regulation of NOTCH4 signaling 54 3.14e-06 2.48e-05 0.45400 0.224000 3.95e-01 4.45e-03 5.04e-07
CD28 dependent PI3K/Akt signaling 22 4.85e-03 1.39e-02 0.45400 -0.400000 -2.14e-01 1.16e-03 8.26e-02
Pre-NOTCH Transcription and Translation 49 3.64e-05 1.95e-04 0.45200 0.257000 3.72e-01 1.85e-03 6.78e-06
Signaling by NTRK1 (TRKA) 100 2.82e-10 5.48e-09 0.45100 0.237000 3.84e-01 4.17e-05 3.32e-11
Inhibition of DNA recombination at telomere 35 1.01e-04 4.91e-04 0.45100 0.186000 4.11e-01 5.63e-02 2.63e-05
Clathrin-mediated endocytosis 125 8.48e-14 2.96e-12 0.45000 0.208000 3.99e-01 6.07e-05 1.32e-14
ER Quality Control Compartment (ERQC) 21 1.14e-02 2.82e-02 0.44900 0.243000 3.77e-01 5.37e-02 2.79e-03
Cleavage of the damaged purine 24 3.69e-03 1.11e-02 0.44800 0.215000 3.93e-01 6.81e-02 8.54e-04
Depurination 24 3.69e-03 1.11e-02 0.44800 0.215000 3.93e-01 6.81e-02 8.54e-04
Recognition and association of DNA glycosylase with site containing an affected purine 24 3.69e-03 1.11e-02 0.44800 0.215000 3.93e-01 6.81e-02 8.54e-04
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 5.29e-05 2.79e-04 0.44800 0.254000 3.69e-01 2.32e-03 9.94e-06
Degradation of GLI1 by the proteasome 57 3.87e-06 2.95e-05 0.44600 0.230000 3.82e-01 2.66e-03 5.98e-07
Vpu mediated degradation of CD4 50 2.05e-05 1.22e-04 0.44500 0.232000 3.80e-01 4.52e-03 3.38e-06
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 8.37e-06 5.62e-05 0.44500 0.220000 3.87e-01 6.06e-03 1.39e-06
Diseases of carbohydrate metabolism 29 9.92e-04 3.65e-03 0.44400 0.203000 3.96e-01 5.89e-02 2.26e-04
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 2.44e-05 1.42e-04 0.44400 0.235000 3.77e-01 4.00e-03 4.05e-06
p53-Independent DNA Damage Response 50 2.44e-05 1.42e-04 0.44400 0.235000 3.77e-01 4.00e-03 4.05e-06
p53-Independent G1/S DNA damage checkpoint 50 2.44e-05 1.42e-04 0.44400 0.235000 3.77e-01 4.00e-03 4.05e-06
Scavenging by Class A Receptors 11 1.32e-01 2.10e-01 0.44400 0.299000 3.28e-01 8.60e-02 5.93e-02
Apoptotic factor-mediated response 18 3.74e-02 7.37e-02 0.44400 0.313000 3.14e-01 2.13e-02 2.11e-02
Removal of the Flap Intermediate 14 2.84e-02 5.91e-02 0.44300 -0.183000 -4.04e-01 2.35e-01 8.94e-03
Fanconi Anemia Pathway 36 1.41e-03 4.92e-03 0.44300 -0.323000 -3.03e-01 8.11e-04 1.64e-03
Glycogen metabolism 23 5.14e-03 1.46e-02 0.44200 0.210000 3.89e-01 8.13e-02 1.23e-03
Metabolism of polyamines 57 2.19e-05 1.29e-04 0.44200 0.276000 3.46e-01 3.18e-04 6.38e-06
Synthesis of PC 23 1.36e-02 3.26e-02 0.44200 0.280000 3.42e-01 2.01e-02 4.52e-03
NIK-->noncanonical NF-kB signaling 57 7.40e-06 5.01e-05 0.44200 0.238000 3.72e-01 1.89e-03 1.18e-06
SHC1 events in ERBB4 signaling 10 1.39e-01 2.19e-01 0.44000 0.360000 2.53e-01 4.85e-02 1.66e-01
Pre-NOTCH Expression and Processing 65 6.05e-07 6.05e-06 0.44000 0.216000 3.83e-01 2.55e-03 9.27e-08
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.66e-02 3.78e-02 0.44000 0.176000 4.03e-01 2.24e-01 5.24e-03
SIRT1 negatively regulates rRNA expression 24 9.93e-03 2.54e-02 0.43900 0.354000 2.60e-01 2.67e-03 2.73e-02
MyD88-independent TLR4 cascade 96 1.60e-09 2.69e-08 0.43900 0.227000 3.76e-01 1.22e-04 1.97e-10
TRIF(TICAM1)-mediated TLR4 signaling 96 1.60e-09 2.69e-08 0.43900 0.227000 3.76e-01 1.22e-04 1.97e-10
Regulation of PTEN stability and activity 66 2.07e-07 2.37e-06 0.43500 0.192000 3.90e-01 7.10e-03 4.23e-08
FOXO-mediated transcription of cell death genes 16 3.12e-02 6.37e-02 0.43400 0.212000 3.79e-01 1.42e-01 8.63e-03
Dectin-1 mediated noncanonical NF-kB signaling 58 6.49e-06 4.49e-05 0.43300 0.223000 3.71e-01 3.31e-03 1.02e-06
Oncogenic MAPK signaling 73 1.58e-06 1.43e-05 0.43100 0.259000 3.45e-01 1.27e-04 3.54e-07
Formation of Fibrin Clot (Clotting Cascade) 26 1.16e-02 2.87e-02 0.43000 0.311000 2.97e-01 6.12e-03 8.80e-03
Ubiquitin-dependent degradation of Cyclin D 50 2.81e-05 1.61e-04 0.42800 0.209000 3.73e-01 1.05e-02 4.95e-06
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 1.69e-04 7.70e-04 0.42800 0.314000 2.90e-01 1.04e-04 3.36e-04
Interleukin-17 signaling 68 6.70e-07 6.57e-06 0.42700 0.208000 3.73e-01 3.00e-03 1.05e-07
Signaling by NOTCH4 78 7.97e-08 9.79e-07 0.42600 0.206000 3.73e-01 1.65e-03 1.20e-08
MAPK targets/ Nuclear events mediated by MAP kinases 31 1.89e-03 6.36e-03 0.42500 0.215000 3.67e-01 3.85e-02 4.02e-04
Signaling by EGFR in Cancer 22 2.42e-02 5.14e-02 0.42500 0.284000 3.17e-01 2.13e-02 1.02e-02
Interferon alpha/beta signaling 57 4.21e-06 3.12e-05 0.42300 -0.377000 -1.92e-01 8.21e-07 1.23e-02
Homologous DNA Pairing and Strand Exchange 42 2.53e-04 1.11e-03 0.42300 -0.217000 -3.63e-01 1.51e-02 4.73e-05
Cargo recognition for clathrin-mediated endocytosis 88 4.01e-09 6.43e-08 0.42200 0.187000 3.79e-01 2.47e-03 8.01e-10
Signaling by PDGFRA extracellular domain mutants 12 1.12e-01 1.86e-01 0.42200 0.347000 2.40e-01 3.73e-02 1.49e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.12e-01 1.86e-01 0.42200 0.347000 2.40e-01 3.73e-02 1.49e-01
Metabolism of porphyrins 22 2.51e-02 5.30e-02 0.42200 0.278000 3.18e-01 2.41e-02 9.90e-03
Golgi-to-ER retrograde transport 111 5.73e-10 1.03e-08 0.42200 0.222000 3.58e-01 5.20e-05 6.86e-11
Autophagy 123 3.51e-10 6.74e-09 0.42000 0.244000 3.42e-01 2.86e-06 5.90e-11
Pexophagy 11 1.07e-01 1.79e-01 0.42000 0.204000 3.67e-01 2.42e-01 3.50e-02
ABC transporter disorders 69 1.04e-06 9.65e-06 0.41900 0.207000 3.65e-01 2.93e-03 1.61e-07
RAB GEFs exchange GTP for GDP on RABs 87 4.32e-08 5.66e-07 0.41900 0.213000 3.61e-01 6.05e-04 5.86e-09
The role of GTSE1 in G2/M progression after G2 checkpoint 58 1.33e-05 8.31e-05 0.41900 0.215000 3.60e-01 4.69e-03 2.17e-06
Endogenous sterols 16 6.24e-02 1.14e-01 0.41800 0.250000 3.36e-01 8.36e-02 2.01e-02
Nucleobase biosynthesis 13 1.93e-03 6.45e-03 0.41800 0.047300 -4.16e-01 7.68e-01 9.46e-03
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 7.17e-03 1.94e-02 0.41800 0.257000 3.30e-01 1.67e-02 2.09e-03
Nucleotide salvage 21 2.61e-02 5.49e-02 0.41800 0.249000 3.36e-01 4.86e-02 7.65e-03
Aquaporin-mediated transport 38 2.08e-03 6.89e-03 0.41800 0.305000 2.86e-01 1.16e-03 2.26e-03
Prostacyclin signalling through prostacyclin receptor 16 6.20e-02 1.13e-01 0.41800 0.337000 2.47e-01 1.97e-02 8.66e-02
Effects of PIP2 hydrolysis 24 7.32e-03 1.97e-02 0.41700 -0.368000 -1.96e-01 1.82e-03 9.66e-02
Negative regulation of FGFR3 signaling 20 2.05e-02 4.46e-02 0.41700 0.210000 3.60e-01 1.04e-01 5.34e-03
Amino acids regulate mTORC1 50 1.38e-04 6.44e-04 0.41600 0.235000 3.43e-01 3.99e-03 2.68e-05
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 2.44e-04 1.07e-03 0.41600 0.157000 3.85e-01 1.09e-01 8.04e-05
Interleukin-10 signaling 35 3.16e-03 9.71e-03 0.41500 0.320000 2.65e-01 1.06e-03 6.63e-03
Acyl chain remodelling of PI 10 2.00e-01 2.92e-01 0.41500 0.307000 2.79e-01 9.28e-02 1.26e-01
Interleukin-4 and Interleukin-13 signaling 92 1.59e-07 1.87e-06 0.41400 0.334000 2.45e-01 3.19e-08 4.71e-05
Vasopressin regulates renal water homeostasis via Aquaporins 34 4.56e-03 1.32e-02 0.41300 0.294000 2.91e-01 3.05e-03 3.30e-03
Protein ubiquitination 72 4.98e-06 3.55e-05 0.41300 0.243000 3.33e-01 3.59e-04 1.01e-06
GPVI-mediated activation cascade 31 3.29e-05 1.79e-04 0.41200 0.063200 4.07e-01 5.42e-01 8.70e-05
VxPx cargo-targeting to cilium 19 1.99e-02 4.36e-02 0.41000 0.184000 3.67e-01 1.66e-01 5.62e-03
tRNA processing in the mitochondrion 32 1.76e-07 2.05e-06 0.41000 -0.405000 6.65e-02 7.36e-05 5.15e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 78 2.39e-06 1.95e-05 0.40900 0.242000 3.29e-01 2.22e-04 4.88e-07
MET promotes cell motility 26 1.78e-02 3.98e-02 0.40900 0.286000 2.92e-01 1.15e-02 1.01e-02
Resolution of Abasic Sites (AP sites) 37 3.27e-03 1.00e-02 0.40800 -0.283000 -2.94e-01 2.90e-03 1.95e-03
Autodegradation of the E3 ubiquitin ligase COP1 49 9.07e-05 4.46e-04 0.40800 0.200000 3.55e-01 1.54e-02 1.67e-05
rRNA modification in the nucleus and cytosol 59 5.77e-06 4.03e-05 0.40700 -0.180000 -3.65e-01 1.65e-02 1.21e-06
CLEC7A (Dectin-1) signaling 96 5.48e-08 6.92e-07 0.40700 0.222000 3.41e-01 1.66e-04 7.64e-09
Intrinsic Pathway of Fibrin Clot Formation 16 7.99e-02 1.40e-01 0.40700 0.313000 2.60e-01 3.00e-02 7.22e-02
Diseases of DNA repair 10 2.12e-01 3.04e-01 0.40600 -0.305000 -2.67e-01 9.44e-02 1.44e-01
Signaling by Insulin receptor 59 1.25e-04 5.86e-04 0.40600 0.284000 2.90e-01 1.62e-04 1.19e-04
Signaling by NOTCH 182 4.60e-15 2.51e-13 0.40500 0.206000 3.49e-01 1.67e-06 4.60e-16
Activation of NF-kappaB in B cells 65 4.60e-06 3.36e-05 0.40500 0.196000 3.54e-01 6.28e-03 7.73e-07
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 3.64e-03 1.10e-02 0.40400 0.312000 2.58e-01 1.21e-03 7.43e-03
Leading Strand Synthesis 14 6.68e-02 1.20e-01 0.40400 -0.190000 -3.57e-01 2.19e-01 2.07e-02
Polymerase switching 14 6.68e-02 1.20e-01 0.40400 -0.190000 -3.57e-01 2.19e-01 2.07e-02
E3 ubiquitin ligases ubiquitinate target proteins 52 9.22e-05 4.52e-04 0.40400 0.210000 3.45e-01 8.87e-03 1.63e-05
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 7.60e-03 2.03e-02 0.40400 0.299000 2.72e-01 3.47e-03 7.65e-03
ERBB2 Regulates Cell Motility 10 2.19e-01 3.13e-01 0.40400 0.278000 2.93e-01 1.28e-01 1.08e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 7.76e-02 1.37e-01 0.40300 0.284000 2.86e-01 4.30e-02 4.14e-02
Transport to the Golgi and subsequent modification 155 7.98e-14 2.86e-12 0.40100 0.181000 3.58e-01 9.86e-05 1.43e-14
Regulation of TP53 Activity through Acetylation 29 8.63e-06 5.77e-05 0.40000 -0.400000 1.33e-02 1.92e-04 9.01e-01
Nucleobase catabolism 28 1.07e-02 2.71e-02 0.40000 0.327000 2.31e-01 2.77e-03 3.47e-02
Signaling by EGFR 45 1.13e-04 5.43e-04 0.40000 0.171000 3.61e-01 4.71e-02 2.73e-05
CD22 mediated BCR regulation 58 1.55e-15 9.58e-14 0.40000 0.197000 -3.48e-01 9.56e-03 4.59e-06
Phase 0 - rapid depolarisation 22 1.53e-02 3.56e-02 0.40000 -0.354000 -1.86e-01 4.07e-03 1.32e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 2.03e-02 4.43e-02 0.39900 0.263000 3.00e-01 2.03e-02 8.02e-03
Membrane Trafficking 555 5.94e-44 2.02e-41 0.39900 0.194000 3.49e-01 5.33e-15 5.80e-45
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 1.20e-02 2.94e-02 0.39800 0.016700 -3.98e-01 9.24e-01 2.23e-02
Caspase activation via extrinsic apoptotic signalling pathway 25 2.50e-02 5.28e-02 0.39800 0.269000 2.93e-01 1.97e-02 1.13e-02
Chondroitin sulfate biosynthesis 12 9.26e-02 1.58e-01 0.39800 0.172000 3.58e-01 3.02e-01 3.16e-02
Receptor Mediated Mitophagy 11 1.89e-01 2.79e-01 0.39700 0.250000 3.09e-01 1.50e-01 7.63e-02
RORA activates gene expression 18 1.54e-02 3.57e-02 0.39700 0.135000 3.74e-01 3.23e-01 6.01e-03
TBC/RABGAPs 45 5.00e-06 3.55e-05 0.39700 0.095000 3.85e-01 2.70e-01 7.65e-06
SCF-beta-TrCP mediated degradation of Emi1 53 6.63e-05 3.37e-04 0.39500 0.189000 3.47e-01 1.76e-02 1.25e-05
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 21 3.86e-02 7.57e-02 0.39400 0.232000 3.18e-01 6.52e-02 1.16e-02
Formation of tubulin folding intermediates by CCT/TriC 22 4.08e-02 7.95e-02 0.39400 0.264000 2.93e-01 3.24e-02 1.73e-02
Metabolism of steroid hormones 19 6.33e-02 1.15e-01 0.39200 0.256000 2.97e-01 5.37e-02 2.48e-02
Uptake and actions of bacterial toxins 27 1.61e-02 3.70e-02 0.39200 0.232000 3.16e-01 3.68e-02 4.49e-03
Presynaptic phase of homologous DNA pairing and strand exchange 39 7.73e-04 2.99e-03 0.39200 -0.181000 -3.48e-01 5.05e-02 1.71e-04
Regulation of RUNX3 expression and activity 55 2.63e-05 1.52e-04 0.39200 0.170000 3.53e-01 2.90e-02 5.93e-06
Regulation of mRNA stability by proteins that bind AU-rich elements 87 2.15e-06 1.81e-05 0.39100 0.237000 3.12e-01 1.32e-04 5.06e-07
Diseases associated with glycosylation precursor biosynthesis 18 5.59e-02 1.04e-01 0.39100 0.216000 3.26e-01 1.13e-01 1.65e-02
Triglyceride catabolism 16 6.31e-02 1.15e-01 0.39100 0.195000 3.39e-01 1.77e-01 1.89e-02
Misspliced GSK3beta mutants stabilize beta-catenin 15 1.74e-02 3.92e-02 0.39000 0.086400 3.81e-01 5.62e-01 1.07e-02
S33 mutants of beta-catenin aren't phosphorylated 15 1.74e-02 3.92e-02 0.39000 0.086400 3.81e-01 5.62e-01 1.07e-02
S37 mutants of beta-catenin aren't phosphorylated 15 1.74e-02 3.92e-02 0.39000 0.086400 3.81e-01 5.62e-01 1.07e-02
S45 mutants of beta-catenin aren't phosphorylated 15 1.74e-02 3.92e-02 0.39000 0.086400 3.81e-01 5.62e-01 1.07e-02
T41 mutants of beta-catenin aren't phosphorylated 15 1.74e-02 3.92e-02 0.39000 0.086400 3.81e-01 5.62e-01 1.07e-02
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 1.74e-02 3.92e-02 0.39000 0.086400 3.81e-01 5.62e-01 1.07e-02
Beta-oxidation of very long chain fatty acids 10 2.06e-01 2.99e-01 0.39000 0.218000 3.24e-01 2.33e-01 7.64e-02
PCP/CE pathway 86 1.48e-08 2.16e-07 0.38900 0.145000 3.61e-01 2.01e-02 6.83e-09
Degradation of AXIN 53 7.88e-05 3.95e-04 0.38900 0.183000 3.43e-01 2.13e-02 1.54e-05
Mitochondrial iron-sulfur cluster biogenesis 13 1.58e-01 2.42e-01 0.38800 0.293000 2.55e-01 6.75e-02 1.11e-01
Condensation of Prophase Chromosomes 29 1.33e-02 3.22e-02 0.38800 0.231000 3.11e-01 3.12e-02 3.72e-03
GRB2 events in ERBB2 signaling 11 1.37e-01 2.16e-01 0.38700 0.344000 1.77e-01 4.79e-02 3.09e-01
Regulation of signaling by CBL 18 3.28e-02 6.63e-02 0.38700 0.165000 3.50e-01 2.24e-01 1.01e-02
Senescence-Associated Secretory Phenotype (SASP) 66 4.21e-06 3.12e-05 0.38600 0.166000 3.49e-01 1.96e-02 9.59e-07
SHC1 events in ERBB2 signaling 17 9.19e-02 1.57e-01 0.38600 0.292000 2.53e-01 3.74e-02 7.11e-02
Glycogen storage diseases 13 1.13e-01 1.86e-01 0.38600 0.193000 3.34e-01 2.28e-01 3.71e-02
Negative regulation of FGFR4 signaling 21 3.04e-02 6.25e-02 0.38600 0.195000 3.33e-01 1.22e-01 8.25e-03
Constitutive Signaling by EGFRvIII 14 1.37e-01 2.16e-01 0.38600 0.297000 2.46e-01 5.41e-02 1.12e-01
Signaling by EGFRvIII in Cancer 14 1.37e-01 2.16e-01 0.38600 0.297000 2.46e-01 5.41e-02 1.12e-01
Activation of BAD and translocation to mitochondria 15 7.05e-02 1.26e-01 0.38500 0.179000 3.41e-01 2.31e-01 2.22e-02
O-glycosylation of TSR domain-containing proteins 25 3.06e-02 6.28e-02 0.38500 -0.252000 -2.91e-01 2.94e-02 1.19e-02
Toll Like Receptor 3 (TLR3) Cascade 92 1.14e-07 1.35e-06 0.38400 0.181000 3.39e-01 2.71e-03 1.86e-08
Integration of energy metabolism 86 4.32e-06 3.18e-05 0.38400 0.235000 3.04e-01 1.64e-04 1.10e-06
Diseases of programmed cell death 27 1.29e-02 3.12e-02 0.38400 0.199000 3.28e-01 7.39e-02 3.17e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 1.38e-03 4.85e-03 0.38300 0.118000 3.65e-01 2.72e-01 6.70e-04
N-Glycan antennae elongation 13 4.13e-03 1.22e-02 0.38300 -0.378000 6.09e-02 1.82e-02 7.04e-01
FGFR1 mutant receptor activation 23 4.41e-02 8.50e-02 0.38100 0.281000 2.58e-01 1.96e-02 3.24e-02
Activation of GABAB receptors 31 1.46e-02 3.44e-02 0.38100 0.253000 2.85e-01 1.47e-02 6.03e-03
GABA B receptor activation 31 1.46e-02 3.44e-02 0.38100 0.253000 2.85e-01 1.47e-02 6.03e-03
Nuclear Events (kinase and transcription factor activation) 53 2.93e-05 1.66e-04 0.38100 0.146000 3.52e-01 6.56e-02 9.45e-06
Trafficking and processing of endosomal TLR 13 1.72e-01 2.61e-01 0.38100 0.256000 2.81e-01 1.10e-01 7.90e-02
Metabolism of amine-derived hormones 10 1.80e-02 4.01e-02 0.38000 0.046600 -3.78e-01 7.99e-01 3.87e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 2.00e-01 2.92e-01 0.38000 0.277000 2.59e-01 9.65e-02 1.20e-01
MASTL Facilitates Mitotic Progression 10 2.63e-01 3.61e-01 0.37900 0.271000 2.65e-01 1.38e-01 1.47e-01
TRAF6 mediated NF-kB activation 23 1.83e-02 4.07e-02 0.37800 0.171000 3.37e-01 1.55e-01 5.08e-03
Polymerase switching on the C-strand of the telomere 26 3.15e-02 6.41e-02 0.37800 -0.259000 -2.76e-01 2.24e-02 1.50e-02
Opioid Signalling 75 1.44e-05 8.82e-05 0.37800 0.209000 3.15e-01 1.71e-03 2.44e-06
PPARA activates gene expression 104 3.49e-09 5.66e-08 0.37700 0.152000 3.46e-01 7.52e-03 1.13e-09
NOTCH1 Intracellular Domain Regulates Transcription 44 2.38e-03 7.44e-03 0.37600 0.231000 2.96e-01 7.89e-03 6.70e-04
Scavenging of heme from plasma 70 2.16e-17 1.73e-15 0.37600 0.250000 -2.80e-01 2.92e-04 5.05e-05
Incretin synthesis, secretion, and inactivation 10 5.59e-02 1.04e-01 0.37500 0.372000 4.59e-02 4.16e-02 8.02e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 5.59e-02 1.04e-01 0.37500 0.372000 4.59e-02 4.16e-02 8.02e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 8.78e-03 2.28e-02 0.37500 0.250000 2.79e-01 9.50e-03 3.71e-03
Negative regulation of FGFR1 signaling 24 2.05e-02 4.46e-02 0.37500 0.181000 3.28e-01 1.24e-01 5.43e-03
Citric acid cycle (TCA cycle) 22 5.38e-03 1.53e-02 0.37400 0.093500 3.63e-01 4.48e-01 3.24e-03
Caspase activation via Death Receptors in the presence of ligand 16 1.14e-01 1.86e-01 0.37400 0.295000 2.31e-01 4.13e-02 1.10e-01
Stabilization of p53 54 3.09e-04 1.33e-03 0.37300 0.199000 3.16e-01 1.16e-02 5.82e-05
EPHA-mediated growth cone collapse 13 9.24e-02 1.58e-01 0.37300 0.151000 3.41e-01 3.46e-01 3.30e-02
L1CAM interactions 83 5.12e-06 3.62e-05 0.37300 0.203000 3.13e-01 1.35e-03 8.17e-07
PI3K events in ERBB2 signaling 11 1.63e-01 2.48e-01 0.37200 0.330000 1.72e-01 5.84e-02 3.22e-01
Myogenesis 21 5.78e-02 1.07e-01 0.37200 0.224000 2.96e-01 7.52e-02 1.88e-02
Oxidative Stress Induced Senescence 79 3.32e-05 1.80e-04 0.37100 0.240000 2.84e-01 2.31e-04 1.29e-05
G beta:gamma signalling through PI3Kgamma 22 2.28e-02 4.89e-02 0.37100 0.162000 3.34e-01 1.90e-01 6.69e-03
Programmed Cell Death 179 2.12e-11 5.28e-10 0.37000 0.215000 3.01e-01 7.04e-07 3.45e-12
G alpha (z) signalling events 36 8.29e-03 2.18e-02 0.37000 0.227000 2.92e-01 1.85e-02 2.42e-03
Translesion synthesis by REV1 16 1.28e-01 2.05e-01 0.36900 -0.242000 -2.78e-01 9.31e-02 5.38e-02
Macroautophagy 109 2.06e-07 2.37e-06 0.36900 0.205000 3.07e-01 2.14e-04 3.09e-08
Plasma lipoprotein clearance 28 1.36e-02 3.27e-02 0.36900 0.184000 3.20e-01 9.23e-02 3.42e-03
Autodegradation of Cdh1 by Cdh1:APC/C 64 7.19e-05 3.63e-04 0.36800 0.190000 3.16e-01 8.57e-03 1.26e-05
VEGFA-VEGFR2 Pathway 90 7.70e-07 7.39e-06 0.36800 0.178000 3.22e-01 3.61e-03 1.24e-07
Cristae formation 31 1.27e-02 3.11e-02 0.36800 0.205000 3.06e-01 4.85e-02 3.21e-03
Post-chaperonin tubulin folding pathway 19 5.49e-03 1.55e-02 0.36700 0.047600 3.64e-01 7.19e-01 5.99e-03
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 1.06e-02 2.69e-02 0.36700 0.038000 3.65e-01 7.93e-01 1.14e-02
Asparagine N-linked glycosylation 269 4.80e-18 4.09e-16 0.36700 0.187000 3.16e-01 1.32e-07 4.39e-19
Pyruvate metabolism 28 2.85e-02 5.91e-02 0.36700 0.278000 2.40e-01 1.10e-02 2.78e-02
p75NTR signals via NF-kB 15 7.93e-02 1.40e-01 0.36600 0.158000 3.31e-01 2.91e-01 2.66e-02
Rab regulation of trafficking 120 7.63e-10 1.33e-08 0.36600 0.148000 3.34e-01 4.99e-03 2.43e-10
Signaling by SCF-KIT 40 6.99e-03 1.90e-02 0.36600 0.254000 2.63e-01 5.39e-03 4.02e-03
Classical antibody-mediated complement activation 68 7.31e-15 3.56e-13 0.36600 0.161000 -3.28e-01 2.16e-02 2.87e-06
Extension of Telomeres 51 1.76e-03 5.98e-03 0.36500 -0.247000 -2.69e-01 2.25e-03 8.90e-04
Endosomal/Vacuolar pathway 12 1.28e-02 3.11e-02 0.36500 -0.363000 3.86e-02 2.95e-02 8.17e-01
Signaling by NOTCH1 66 8.99e-05 4.44e-04 0.36500 0.197000 3.07e-01 5.71e-03 1.60e-05
MAPK6/MAPK4 signaling 82 3.09e-05 1.73e-04 0.36400 0.230000 2.82e-01 3.14e-04 1.00e-05
Hedgehog 'on' state 74 1.26e-05 7.92e-05 0.36200 0.173000 3.18e-01 1.02e-02 2.24e-06
Interleukin-15 signaling 14 1.82e-01 2.72e-01 0.36200 0.249000 2.62e-01 1.07e-01 8.95e-02
Mitotic Telophase/Cytokinesis 13 2.00e-01 2.92e-01 0.36100 0.233000 2.76e-01 1.46e-01 8.47e-02
GABA receptor activation 36 1.27e-02 3.10e-02 0.36000 0.242000 2.67e-01 1.19e-02 5.60e-03
Regulation of insulin secretion 60 7.52e-04 2.91e-03 0.36000 0.251000 2.58e-01 7.80e-04 5.51e-04
AMER1 mutants destabilize the destruction complex 14 3.41e-02 6.80e-02 0.36000 0.067300 3.53e-01 6.63e-01 2.21e-02
APC truncation mutants have impaired AXIN binding 14 3.41e-02 6.80e-02 0.36000 0.067300 3.53e-01 6.63e-01 2.21e-02
AXIN missense mutants destabilize the destruction complex 14 3.41e-02 6.80e-02 0.36000 0.067300 3.53e-01 6.63e-01 2.21e-02
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 3.41e-02 6.80e-02 0.36000 0.067300 3.53e-01 6.63e-01 2.21e-02
Truncations of AMER1 destabilize the destruction complex 14 3.41e-02 6.80e-02 0.36000 0.067300 3.53e-01 6.63e-01 2.21e-02
truncated APC mutants destabilize the destruction complex 14 3.41e-02 6.80e-02 0.36000 0.067300 3.53e-01 6.63e-01 2.21e-02
Creation of C4 and C2 activators 70 4.10e-15 2.43e-13 0.35900 0.174000 -3.14e-01 1.18e-02 5.41e-06
Regulation of lipid metabolism by PPARalpha 106 8.95e-09 1.35e-07 0.35900 0.138000 3.32e-01 1.42e-02 3.61e-09
Signaling by Interleukins 385 1.98e-21 2.08e-19 0.35900 0.220000 2.84e-01 1.37e-13 1.03e-21
Selenocysteine synthesis 91 1.36e-05 8.41e-05 0.35800 -0.223000 -2.80e-01 2.39e-04 3.94e-06
Folding of actin by CCT/TriC 10 1.76e-01 2.66e-01 0.35800 0.330000 1.38e-01 7.07e-02 4.51e-01
Apoptosis 167 4.84e-10 8.92e-09 0.35700 0.207000 2.92e-01 4.01e-06 7.84e-11
APC/C:Cdc20 mediated degradation of Securin 66 7.95e-05 3.97e-04 0.35700 0.179000 3.09e-01 1.20e-02 1.42e-05
Cleavage of the damaged pyrimidine 29 1.11e-02 2.77e-02 0.35600 0.159000 3.19e-01 1.38e-01 2.99e-03
Depyrimidination 29 1.11e-02 2.77e-02 0.35600 0.159000 3.19e-01 1.38e-01 2.99e-03
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 1.11e-02 2.77e-02 0.35600 0.159000 3.19e-01 1.38e-01 2.99e-03
Platelet homeostasis 67 1.03e-04 4.98e-04 0.35600 0.187000 3.03e-01 8.06e-03 1.83e-05
PKA activation 15 5.27e-02 9.92e-02 0.35600 0.108000 3.39e-01 4.67e-01 2.31e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 4.94e-04 1.98e-03 0.35500 0.175000 3.09e-01 2.75e-02 9.83e-05
PLC beta mediated events 43 2.98e-03 9.20e-03 0.35400 0.188000 3.01e-01 3.33e-02 6.50e-04
Defective B3GALTL causes Peters-plus syndrome (PpS) 24 5.79e-02 1.07e-01 0.35400 -0.230000 -2.70e-01 5.15e-02 2.22e-02
XBP1(S) activates chaperone genes 47 5.47e-05 2.87e-04 0.35300 0.090400 3.41e-01 2.84e-01 5.16e-05
C-type lectin receptors (CLRs) 128 9.15e-08 1.10e-06 0.35300 0.201000 2.90e-01 8.79e-05 1.46e-08
Carnitine metabolism 10 2.85e-01 3.84e-01 0.35200 0.204000 2.87e-01 2.65e-01 1.16e-01
Rap1 signalling 13 2.02e-01 2.94e-01 0.35200 0.209000 2.83e-01 1.91e-01 7.71e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 179 7.30e-12 2.07e-10 0.35100 0.167000 3.09e-01 1.16e-04 1.00e-12
Purine ribonucleoside monophosphate biosynthesis 10 1.67e-02 3.81e-02 0.35100 0.113000 -3.32e-01 5.35e-01 6.88e-02
Metalloprotease DUBs 21 5.72e-02 1.06e-01 0.35100 0.179000 3.01e-01 1.56e-01 1.68e-02
TNFR1-induced proapoptotic signaling 12 2.55e-01 3.51e-01 0.35000 -0.256000 -2.38e-01 1.24e-01 1.54e-01
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 2.89e-05 1.65e-04 0.34900 0.161000 3.09e-01 1.82e-02 5.64e-06
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 4.24e-03 1.25e-02 0.34800 0.126000 3.24e-01 2.18e-01 1.49e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 1.32e-01 2.10e-01 0.34800 0.248000 2.44e-01 6.85e-02 7.32e-02
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 1.32e-01 2.10e-01 0.34800 0.248000 2.44e-01 6.85e-02 7.32e-02
Degradation of beta-catenin by the destruction complex 83 4.19e-06 3.12e-05 0.34800 0.153000 3.12e-01 1.59e-02 8.86e-07
Vesicle-mediated transport 644 3.04e-33 6.90e-31 0.34700 0.207000 2.79e-01 3.64e-19 1.28e-33
Acyl chain remodelling of PC 19 1.19e-01 1.93e-01 0.34700 0.236000 2.54e-01 7.53e-02 5.51e-02
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 1.62e-01 2.48e-01 0.34600 0.223000 2.65e-01 1.22e-01 6.69e-02
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 4.40e-03 1.28e-02 0.34600 0.172000 3.01e-01 6.04e-02 1.00e-03
Asymmetric localization of PCP proteins 60 6.21e-05 3.18e-04 0.34500 0.133000 3.19e-01 7.40e-02 1.95e-05
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 1.46e-04 6.72e-04 0.34400 0.133000 3.18e-01 8.82e-02 4.55e-05
Interleukin-27 signaling 11 2.87e-01 3.86e-01 0.34400 0.216000 2.68e-01 2.15e-01 1.24e-01
Deadenylation of mRNA 22 3.06e-02 6.27e-02 0.34400 0.316000 1.34e-01 1.02e-02 2.75e-01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 8.84e-02 1.53e-01 0.34300 0.168000 2.99e-01 2.16e-01 2.80e-02
Respiratory electron transport 101 4.86e-07 5.06e-06 0.34300 0.153000 3.07e-01 7.94e-03 9.65e-08
IRE1alpha activates chaperones 49 5.77e-05 3.00e-04 0.34300 0.085100 3.32e-01 3.02e-01 5.79e-05
FCGR activation 75 3.32e-14 1.43e-12 0.34200 0.143000 -3.11e-01 3.22e-02 3.24e-06
RA biosynthesis pathway 13 1.75e-01 2.64e-01 0.34200 -0.298000 -1.66e-01 6.26e-02 2.99e-01
Laminin interactions 21 6.44e-02 1.17e-01 0.34100 0.295000 1.71e-01 1.93e-02 1.75e-01
Extra-nuclear estrogen signaling 65 9.00e-04 3.41e-03 0.34000 0.251000 2.30e-01 4.77e-04 1.31e-03
Activated NOTCH1 Transmits Signal to the Nucleus 27 6.24e-03 1.71e-02 0.34000 0.093900 3.27e-01 3.98e-01 3.26e-03
Signaling by Non-Receptor Tyrosine Kinases 47 2.59e-03 8.05e-03 0.34000 0.176000 2.91e-01 3.72e-02 5.59e-04
Signaling by PTK6 47 2.59e-03 8.05e-03 0.34000 0.176000 2.91e-01 3.72e-02 5.59e-04
TICAM1,TRAF6-dependent induction of TAK1 complex 11 2.81e-01 3.82e-01 0.34000 0.200000 2.74e-01 2.50e-01 1.15e-01
NF-kB is activated and signals survival 12 6.86e-02 1.23e-01 0.34000 0.055200 3.35e-01 7.41e-01 4.44e-02
Peptide chain elongation 87 6.28e-05 3.21e-04 0.33900 -0.209000 -2.67e-01 7.58e-04 1.68e-05
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 2.98e-08 4.03e-07 0.33900 0.152000 3.03e-01 3.52e-03 5.68e-09
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 1.58e-02 3.65e-02 0.33800 -0.000913 3.38e-01 9.95e-01 2.34e-02
Adenylate cyclase inhibitory pathway 11 5.03e-02 9.53e-02 0.33800 0.003620 3.38e-01 9.83e-01 5.23e-02
Glycerophospholipid biosynthesis 106 1.39e-05 8.60e-05 0.33800 0.234000 2.43e-01 3.09e-05 1.52e-05
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.62e-02 3.71e-02 0.33800 0.099800 3.23e-01 4.07e-01 7.41e-03
CDT1 association with the CDC6:ORC:origin complex 57 8.03e-04 3.09e-03 0.33700 0.174000 2.89e-01 2.33e-02 1.60e-04
EPH-ephrin mediated repulsion of cells 39 5.57e-03 1.57e-02 0.33700 0.159000 2.97e-01 8.56e-02 1.35e-03
FRS-mediated FGFR3 signaling 11 1.84e-01 2.74e-01 0.33600 0.311000 1.29e-01 7.45e-02 4.59e-01
IRAK2 mediated activation of TAK1 complex 10 2.36e-01 3.31e-01 0.33600 0.141000 3.05e-01 4.39e-01 9.51e-02
SARS-CoV-2 Infection 63 2.45e-05 1.42e-04 0.33600 0.110000 3.18e-01 1.32e-01 1.30e-05
rRNA processing in the mitochondrion 29 5.07e-04 2.03e-03 0.33600 -0.336000 -1.04e-02 1.75e-03 9.22e-01
Surfactant metabolism 22 1.00e-01 1.68e-01 0.33600 0.240000 2.35e-01 5.18e-02 5.60e-02
Heme biosynthesis 14 2.31e-01 3.25e-01 0.33600 0.241000 2.33e-01 1.18e-01 1.31e-01
Chaperone Mediated Autophagy 19 1.23e-01 1.97e-01 0.33500 0.267000 2.03e-01 4.38e-02 1.26e-01
Transcriptional regulation of white adipocyte differentiation 77 1.97e-06 1.71e-05 0.33500 0.105000 3.18e-01 1.10e-01 1.41e-06
G-protein mediated events 44 3.59e-03 1.09e-02 0.33400 0.163000 2.92e-01 6.07e-02 8.17e-04
Synthesis of PIPs at the late endosome membrane 11 2.89e-01 3.88e-01 0.33400 0.272000 1.93e-01 1.18e-01 2.67e-01
Gluconeogenesis 28 8.56e-03 2.25e-02 0.33300 0.104000 3.17e-01 3.41e-01 3.74e-03
Initiation of Nuclear Envelope (NE) Reformation 19 1.31e-02 3.18e-02 0.33300 0.040000 3.31e-01 7.63e-01 1.26e-02
Initial triggering of complement 77 3.37e-14 1.43e-12 0.33200 0.158000 -2.92e-01 1.65e-02 9.18e-06
Rev-mediated nuclear export of HIV RNA 35 5.52e-03 1.55e-02 0.33200 -0.129000 -3.06e-01 1.87e-01 1.74e-03
Glycosphingolipid metabolism 36 2.13e-03 6.95e-03 0.33100 0.099600 3.16e-01 3.01e-01 1.04e-03
Signaling by FGFR1 in disease 30 3.14e-02 6.40e-02 0.33100 0.277000 1.81e-01 8.59e-03 8.64e-02
ESR-mediated signaling 159 4.45e-08 5.78e-07 0.33000 0.200000 2.63e-01 1.36e-05 1.05e-08
Semaphorin interactions 57 5.79e-04 2.29e-03 0.32900 0.150000 2.93e-01 4.96e-02 1.29e-04
Inwardly rectifying K+ channels 24 5.94e-02 1.09e-01 0.32900 0.280000 1.73e-01 1.75e-02 1.42e-01
Role of LAT2/NTAL/LAB on calcium mobilization 73 4.31e-14 1.78e-12 0.32900 0.230000 -2.36e-01 6.84e-04 4.98e-04
Downstream signaling events of B Cell Receptor (BCR) 79 3.27e-05 1.79e-04 0.32900 0.149000 2.93e-01 2.19e-02 6.65e-06
rRNA processing in the nucleus and cytosol 189 1.39e-11 3.64e-10 0.32800 -0.145000 -2.95e-01 5.89e-04 2.82e-12
Complex I biogenesis 55 1.14e-04 5.43e-04 0.32800 0.102000 3.12e-01 1.91e-01 6.26e-05
CDK-mediated phosphorylation and removal of Cdc6 71 2.40e-04 1.05e-03 0.32800 0.171000 2.80e-01 1.29e-02 4.45e-05
Eukaryotic Translation Elongation 92 7.43e-05 3.74e-04 0.32800 -0.204000 -2.56e-01 7.33e-04 2.12e-05
Major pathway of rRNA processing in the nucleolus and cytosol 179 5.49e-11 1.31e-09 0.32700 -0.144000 -2.94e-01 8.97e-04 1.14e-11
Interactions of Rev with host cellular proteins 37 4.06e-03 1.21e-02 0.32700 -0.121000 -3.04e-01 2.01e-01 1.37e-03
Base-Excision Repair, AP Site Formation 31 1.43e-02 3.39e-02 0.32700 0.137000 2.97e-01 1.87e-01 4.23e-03
Signaling by FGFR3 31 3.20e-02 6.47e-02 0.32700 0.182000 2.72e-01 8.01e-02 8.83e-03
Signaling by Receptor Tyrosine Kinases 408 7.11e-22 8.08e-20 0.32700 0.161000 2.84e-01 2.19e-08 6.76e-23
Signaling by Hippo 18 1.66e-01 2.53e-01 0.32600 0.217000 2.44e-01 1.11e-01 7.32e-02
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 2.23e-03 7.10e-03 0.32600 0.171000 2.77e-01 3.08e-02 4.75e-04
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 2.23e-03 7.10e-03 0.32600 0.171000 2.77e-01 3.08e-02 4.75e-04
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 2.23e-03 7.10e-03 0.32600 0.171000 2.77e-01 3.08e-02 4.75e-04
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 2.23e-03 7.10e-03 0.32600 0.171000 2.77e-01 3.08e-02 4.75e-04
Signaling by NOTCH1 in Cancer 53 2.23e-03 7.10e-03 0.32600 0.171000 2.77e-01 3.08e-02 4.75e-04
HDR through Single Strand Annealing (SSA) 37 1.27e-02 3.11e-02 0.32600 -0.165000 -2.80e-01 8.17e-02 3.15e-03
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 4.48e-04 1.82e-03 0.32500 0.184000 2.68e-01 7.38e-03 9.15e-05
PINK1-PRKN Mediated Mitophagy 21 6.76e-02 1.21e-01 0.32500 0.290000 1.47e-01 2.15e-02 2.44e-01
Pausing and recovery of Tat-mediated HIV elongation 30 2.00e-05 1.19e-04 0.32500 -0.118000 3.03e-01 2.64e-01 4.10e-03
Tat-mediated HIV elongation arrest and recovery 30 2.00e-05 1.19e-04 0.32500 -0.118000 3.03e-01 2.64e-01 4.10e-03
TGF-beta receptor signaling activates SMADs 32 6.08e-03 1.69e-02 0.32500 0.104000 3.08e-01 3.08e-01 2.58e-03
HDMs demethylate histones 22 1.45e-03 5.03e-03 0.32500 -0.044400 3.22e-01 7.19e-01 8.96e-03
SCF(Skp2)-mediated degradation of p27/p21 60 9.28e-04 3.49e-03 0.32500 0.167000 2.79e-01 2.56e-02 1.87e-04
Activation of gene expression by SREBF (SREBP) 42 2.13e-03 6.96e-03 0.32500 0.120000 3.02e-01 1.77e-01 7.19e-04
Tie2 Signaling 16 2.00e-01 2.92e-01 0.32400 0.205000 2.51e-01 1.56e-01 8.19e-02
Biosynthesis of specialized proresolving mediators (SPMs) 16 1.95e-01 2.87e-01 0.32400 0.198000 2.56e-01 1.69e-01 7.61e-02
Signaling by FGFR4 31 4.50e-02 8.65e-02 0.32300 0.205000 2.50e-01 4.87e-02 1.58e-02
Translesion synthesis by POLI 17 1.69e-01 2.57e-01 0.32300 -0.190000 -2.62e-01 1.75e-01 6.19e-02
Eukaryotic Translation Termination 91 1.20e-04 5.68e-04 0.32300 -0.205000 -2.49e-01 7.40e-04 3.93e-05
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 4.50e-04 1.83e-03 0.32200 0.181000 2.67e-01 7.87e-03 9.12e-05
Chaperonin-mediated protein folding 84 6.02e-05 3.11e-04 0.32200 0.163000 2.78e-01 9.84e-03 1.06e-05
Aggrephagy 21 1.06e-01 1.78e-01 0.32200 0.182000 2.66e-01 1.50e-01 3.49e-02
Constitutive Signaling by Overexpressed ERBB2 11 3.40e-01 4.45e-01 0.32200 0.208000 2.45e-01 2.32e-01 1.59e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 9.71e-02 1.64e-01 0.32100 0.149000 2.84e-01 2.61e-01 3.19e-02
Costimulation by the CD28 family 74 7.37e-04 2.86e-03 0.32000 -0.247000 -2.03e-01 2.39e-04 2.53e-03
RHO GTPase Effectors 248 1.12e-12 3.47e-11 0.31900 0.165000 2.73e-01 7.43e-06 1.19e-13
UCH proteinases 86 8.05e-08 9.80e-07 0.31900 0.059300 3.14e-01 3.42e-01 4.96e-07
Ca-dependent events 29 2.42e-02 5.14e-02 0.31900 0.137000 2.88e-01 2.02e-01 7.23e-03
Hemostasis 542 1.80e-22 2.45e-20 0.31900 0.217000 2.33e-01 4.53e-18 1.78e-20
Apoptotic execution phase 45 1.00e-02 2.57e-02 0.31900 0.185000 2.59e-01 3.19e-02 2.61e-03
Plasma lipoprotein assembly, remodeling, and clearance 52 2.27e-03 7.20e-03 0.31800 0.154000 2.79e-01 5.50e-02 5.04e-04
p38MAPK events 13 2.27e-01 3.22e-01 0.31800 0.160000 2.76e-01 3.19e-01 8.54e-02
CD28 dependent Vav1 pathway 12 2.08e-01 3.00e-01 0.31800 0.289000 1.31e-01 8.25e-02 4.33e-01
Sphingolipid metabolism 78 1.41e-04 6.55e-04 0.31800 0.158000 2.75e-01 1.56e-02 2.61e-05
Sphingolipid de novo biosynthesis 42 1.86e-02 4.11e-02 0.31800 0.208000 2.40e-01 1.96e-02 7.17e-03
NOD1/2 Signaling Pathway 32 4.23e-02 8.21e-02 0.31700 0.192000 2.53e-01 5.97e-02 1.34e-02
Regulation of RAS by GAPs 66 1.47e-04 6.74e-04 0.31700 0.126000 2.91e-01 7.69e-02 4.27e-05
Signaling by VEGF 97 4.56e-06 3.34e-05 0.31600 0.134000 2.86e-01 2.21e-02 1.08e-06
Nuclear signaling by ERBB4 24 7.06e-02 1.26e-01 0.31600 0.162000 2.71e-01 1.70e-01 2.13e-02
ABC-family proteins mediated transport 92 5.43e-05 2.86e-04 0.31400 0.165000 2.67e-01 6.13e-03 9.34e-06
The citric acid (TCA) cycle and respiratory electron transport 172 2.28e-09 3.79e-08 0.31400 0.148000 2.77e-01 8.13e-04 3.49e-10
Binding and Uptake of Ligands by Scavenger Receptors 91 9.23e-15 4.34e-13 0.31400 0.280000 -1.42e-01 3.95e-06 1.90e-02
Selective autophagy 57 5.52e-03 1.55e-02 0.31400 0.216000 2.27e-01 4.70e-03 3.05e-03
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 3.48e-04 1.47e-03 0.31400 0.165000 2.66e-01 1.34e-02 6.59e-05
NEP/NS2 Interacts with the Cellular Export Machinery 32 7.05e-03 1.92e-02 0.31300 -0.092100 -2.99e-01 3.67e-01 3.37e-03
Viral mRNA Translation 87 2.22e-04 9.81e-04 0.31300 -0.187000 -2.51e-01 2.55e-03 5.18e-05
p53-Dependent G1 DNA Damage Response 63 1.15e-03 4.11e-03 0.31300 0.161000 2.68e-01 2.74e-02 2.34e-04
p53-Dependent G1/S DNA damage checkpoint 63 1.15e-03 4.11e-03 0.31300 0.161000 2.68e-01 2.74e-02 2.34e-04
APC/C:Cdc20 mediated degradation of mitotic proteins 74 4.48e-04 1.82e-03 0.31200 0.167000 2.64e-01 1.30e-02 8.63e-05
Signaling by ERBB4 44 1.61e-02 3.71e-02 0.31200 0.195000 2.44e-01 2.53e-02 5.15e-03
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 2.09e-01 3.00e-01 0.31200 -0.152000 -2.72e-01 3.26e-01 7.75e-02
Listeria monocytogenes entry into host cells 17 1.59e-01 2.43e-01 0.31000 0.156000 2.68e-01 2.66e-01 5.53e-02
SARS-CoV-1 Infection 47 3.48e-04 1.47e-03 0.31000 0.069200 3.02e-01 4.12e-01 3.38e-04
Synthesis of very long-chain fatty acyl-CoAs 21 1.53e-01 2.35e-01 0.30900 0.230000 2.07e-01 6.86e-02 1.00e-01
Signaling by NOTCH3 42 2.36e-03 7.39e-03 0.30900 0.099300 2.93e-01 2.66e-01 1.03e-03
Interleukin-12 signaling 44 1.99e-02 4.36e-02 0.30900 0.208000 2.28e-01 1.68e-02 8.81e-03
G1/S DNA Damage Checkpoints 65 1.49e-03 5.13e-03 0.30900 0.169000 2.58e-01 1.85e-02 3.13e-04
rRNA processing 218 4.60e-10 8.59e-09 0.30900 -0.171000 -2.57e-01 1.37e-05 5.96e-11
HIV elongation arrest and recovery 32 2.99e-05 1.68e-04 0.30800 -0.115000 2.85e-01 2.59e-01 5.25e-03
Pausing and recovery of HIV elongation 32 2.99e-05 1.68e-04 0.30800 -0.115000 2.85e-01 2.59e-01 5.25e-03
Nitric oxide stimulates guanylate cyclase 14 2.08e-01 3.00e-01 0.30700 0.272000 1.44e-01 7.82e-02 3.52e-01
Tryptophan catabolism 12 3.09e-01 4.09e-01 0.30700 0.255000 1.71e-01 1.26e-01 3.04e-01
Interleukin-6 family signaling 18 1.79e-01 2.69e-01 0.30700 0.251000 1.77e-01 6.55e-02 1.93e-01
Cytosolic iron-sulfur cluster assembly 13 5.21e-02 9.83e-02 0.30700 -0.307000 3.92e-04 5.55e-02 9.98e-01
NGF-stimulated transcription 31 2.72e-02 5.67e-02 0.30700 0.135000 2.75e-01 1.93e-01 8.00e-03
Regulation of RUNX2 expression and activity 66 8.78e-04 3.33e-03 0.30600 0.150000 2.66e-01 3.49e-02 1.81e-04
Signaling by ERBB2 in Cancer 21 1.23e-01 1.97e-01 0.30600 0.258000 1.64e-01 4.06e-02 1.93e-01
Beta-catenin independent WNT signaling 136 4.08e-07 4.53e-06 0.30600 0.147000 2.68e-01 3.15e-03 6.53e-08
NS1 Mediated Effects on Host Pathways 40 1.52e-02 3.54e-02 0.30500 -0.153000 -2.64e-01 9.38e-02 3.85e-03
NOTCH3 Intracellular Domain Regulates Transcription 20 5.56e-02 1.04e-01 0.30500 0.092800 2.91e-01 4.73e-01 2.44e-02
Processive synthesis on the C-strand of the telomere 19 1.89e-01 2.80e-01 0.30400 -0.198000 -2.31e-01 1.36e-01 8.09e-02
The role of Nef in HIV-1 replication and disease pathogenesis 28 4.94e-02 9.41e-02 0.30300 0.144000 2.67e-01 1.86e-01 1.46e-02
TP53 Regulates Metabolic Genes 85 3.16e-04 1.35e-03 0.30200 0.168000 2.51e-01 7.32e-03 6.18e-05
Interleukin-12 family signaling 53 1.12e-02 2.79e-02 0.30200 0.212000 2.16e-01 7.53e-03 6.64e-03
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 1.69e-02 3.84e-02 0.30200 -0.105000 -2.83e-01 3.10e-01 6.34e-03
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 1.69e-02 3.84e-02 0.30200 -0.105000 -2.83e-01 3.10e-01 6.34e-03
Acyl chain remodelling of PG 11 3.88e-01 4.92e-01 0.30100 0.229000 1.95e-01 1.88e-01 2.62e-01
cGMP effects 12 3.61e-01 4.66e-01 0.30100 0.225000 2.00e-01 1.77e-01 2.31e-01
Depolymerisation of the Nuclear Lamina 15 2.03e-01 2.95e-01 0.30000 0.142000 2.65e-01 3.42e-01 7.57e-02
Diseases of signal transduction by growth factor receptors and second messengers 339 7.52e-16 4.88e-14 0.30000 0.145000 2.63e-01 4.51e-06 8.91e-17
AKT phosphorylates targets in the nucleus 10 5.73e-02 1.06e-01 0.30000 -0.289000 8.05e-02 1.14e-01 6.59e-01
p75NTR recruits signalling complexes 12 2.52e-01 3.48e-01 0.29900 0.126000 2.72e-01 4.51e-01 1.03e-01
Nuclear import of Rev protein 34 1.41e-02 3.35e-02 0.29900 -0.109000 -2.78e-01 2.71e-01 4.97e-03
PRC2 methylates histones and DNA 29 8.95e-02 1.54e-01 0.29900 0.203000 2.19e-01 5.83e-02 4.10e-02
Estrogen-dependent gene expression 98 8.66e-05 4.31e-04 0.29900 0.159000 2.53e-01 6.47e-03 1.53e-05
Degradation of the extracellular matrix 78 9.03e-04 3.41e-03 0.29900 0.173000 2.43e-01 8.34e-03 2.01e-04
Intra-Golgi traffic 43 7.74e-03 2.06e-02 0.29800 0.126000 2.70e-01 1.54e-01 2.19e-03
Signalling to RAS 18 2.29e-01 3.23e-01 0.29700 0.211000 2.10e-01 1.22e-01 1.24e-01
Protein folding 90 3.93e-05 2.09e-04 0.29700 0.124000 2.69e-01 4.19e-02 9.89e-06
Diseases associated with O-glycosylation of proteins 47 1.63e-02 3.72e-02 0.29600 -0.240000 -1.74e-01 4.49e-03 3.87e-02
Attenuation phase 23 1.48e-01 2.29e-01 0.29500 0.189000 2.27e-01 1.17e-01 5.93e-02
Translesion synthesis by POLK 17 2.32e-01 3.26e-01 0.29500 -0.177000 -2.36e-01 2.07e-01 9.19e-02
Vpr-mediated nuclear import of PICs 34 1.09e-02 2.74e-02 0.29500 -0.092100 -2.80e-01 3.53e-01 4.72e-03
PTEN Regulation 138 6.97e-08 8.71e-07 0.29500 0.110000 2.73e-01 2.55e-02 2.96e-08
RIP-mediated NFkB activation via ZBP1 17 4.29e-02 8.29e-02 0.29400 0.027300 2.93e-01 8.46e-01 3.64e-02
tRNA modification in the nucleus and cytosol 43 1.42e-03 4.92e-03 0.29400 -0.066000 -2.87e-01 4.54e-01 1.14e-03
Regulation of localization of FOXO transcription factors 12 4.05e-02 7.92e-02 0.29400 -0.068800 2.86e-01 6.80e-01 8.63e-02
Regulation of TP53 Activity through Association with Co-factors 12 1.36e-01 2.16e-01 0.29400 -0.290000 -4.88e-02 8.24e-02 7.70e-01
FRS-mediated FGFR4 signaling 12 2.23e-01 3.17e-01 0.29300 0.275000 1.01e-01 9.85e-02 5.43e-01
RIPK1-mediated regulated necrosis 29 9.52e-02 1.62e-01 0.29300 0.191000 2.22e-01 7.52e-02 3.82e-02
Regulated Necrosis 29 9.52e-02 1.62e-01 0.29300 0.191000 2.22e-01 7.52e-02 3.82e-02
Regulation of necroptotic cell death 29 9.52e-02 1.62e-01 0.29300 0.191000 2.22e-01 7.52e-02 3.82e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 9.85e-02 1.66e-01 0.29300 -0.163000 -2.43e-01 1.50e-01 3.17e-02
Integrin cell surface interactions 52 1.56e-02 3.61e-02 0.29300 0.217000 1.97e-01 6.86e-03 1.41e-02
Mitochondrial tRNA aminoacylation 21 1.82e-01 2.72e-01 0.29300 -0.189000 -2.23e-01 1.33e-01 7.66e-02
B-WICH complex positively regulates rRNA expression 44 1.80e-02 4.01e-02 0.29300 0.247000 1.57e-01 4.61e-03 7.15e-02
COPI-dependent Golgi-to-ER retrograde traffic 78 3.77e-04 1.56e-03 0.29200 0.135000 2.58e-01 3.89e-02 8.01e-05
SUMOylation of intracellular receptors 25 2.26e-02 4.86e-02 0.29100 0.062300 2.84e-01 5.90e-01 1.39e-02
Mitophagy 28 9.84e-02 1.66e-01 0.29000 0.231000 1.76e-01 3.42e-02 1.08e-01
Role of phospholipids in phagocytosis 87 3.18e-12 9.22e-11 0.29000 0.135000 -2.57e-01 3.01e-02 3.51e-05
Sialic acid metabolism 28 9.83e-02 1.66e-01 0.28900 0.172000 2.32e-01 1.16e-01 3.34e-02
Signaling by Nuclear Receptors 214 5.26e-09 8.24e-08 0.28900 0.153000 2.45e-01 1.17e-04 6.64e-10
Metabolism of nitric oxide: NOS3 activation and regulation 12 3.53e-01 4.59e-01 0.28900 0.160000 2.40e-01 3.37e-01 1.50e-01
Disorders of Developmental Biology 12 1.19e-01 1.92e-01 0.28800 0.026100 2.87e-01 8.76e-01 8.55e-02
Disorders of Nervous System Development 12 1.19e-01 1.92e-01 0.28800 0.026100 2.87e-01 8.76e-01 8.55e-02
Loss of function of MECP2 in Rett syndrome 12 1.19e-01 1.92e-01 0.28800 0.026100 2.87e-01 8.76e-01 8.55e-02
Pervasive developmental disorders 12 1.19e-01 1.92e-01 0.28800 0.026100 2.87e-01 8.76e-01 8.55e-02
Activation of kainate receptors upon glutamate binding 25 1.43e-01 2.23e-01 0.28700 0.217000 1.89e-01 6.03e-02 1.03e-01
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 93 4.02e-04 1.65e-03 0.28700 -0.164000 -2.36e-01 6.29e-03 8.33e-05
Purine salvage 12 3.99e-01 5.03e-01 0.28700 0.202000 2.04e-01 2.25e-01 2.21e-01
Striated Muscle Contraction 24 1.14e-01 1.87e-01 0.28500 0.246000 1.45e-01 3.72e-02 2.18e-01
Defects in vitamin and cofactor metabolism 21 1.48e-01 2.29e-01 0.28500 -0.144000 -2.46e-01 2.52e-01 5.08e-02
Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.21e-02 2.96e-02 0.28500 0.157000 2.38e-01 5.05e-02 3.00e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 2.22e-02 4.79e-02 0.28500 0.052000 2.80e-01 6.53e-01 1.54e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 2.22e-03 7.10e-03 0.28400 -0.088300 2.70e-01 4.64e-01 2.48e-02
Regulation of actin dynamics for phagocytic cup formation 122 7.10e-08 8.80e-07 0.28400 0.275000 7.26e-02 1.59e-07 1.66e-01
Signaling by WNT 253 9.98e-12 2.74e-10 0.28300 0.121000 2.56e-01 9.01e-04 2.45e-12
TCF dependent signaling in response to WNT 165 1.56e-08 2.27e-07 0.28000 0.103000 2.60e-01 2.27e-02 7.76e-09
tRNA processing in the nucleus 59 1.53e-03 5.24e-03 0.27900 -0.101000 -2.60e-01 1.81e-01 5.43e-04
Plasma lipoprotein assembly 10 2.69e-01 3.67e-01 0.27800 0.069400 2.70e-01 7.04e-01 1.40e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 2.76e-02 5.75e-02 0.27800 -0.095600 -2.61e-01 3.49e-01 1.06e-02
Intraflagellar transport 39 5.51e-02 1.04e-01 0.27800 -0.173000 -2.17e-01 6.20e-02 1.89e-02
Peroxisomal lipid metabolism 27 1.47e-01 2.28e-01 0.27700 0.199000 1.93e-01 7.41e-02 8.33e-02
SARS-CoV Infections 140 4.28e-07 4.63e-06 0.27500 0.102000 2.56e-01 3.73e-02 1.77e-07
RNA Polymerase I Promoter Escape 44 3.73e-02 7.36e-02 0.27500 0.221000 1.64e-01 1.14e-02 6.02e-02
Regulation of Complement cascade 93 1.56e-12 4.61e-11 0.27400 0.203000 -1.85e-01 7.10e-04 2.09e-03
Activation of RAC1 11 4.61e-01 5.63e-01 0.27400 0.205000 1.82e-01 2.40e-01 2.95e-01
ZBP1(DAI) mediated induction of type I IFNs 20 4.72e-02 9.04e-02 0.27400 0.035000 2.72e-01 7.86e-01 3.55e-02
Interactions of Vpr with host cellular proteins 37 2.46e-02 5.21e-02 0.27300 -0.107000 -2.51e-01 2.59e-01 8.12e-03
Transcriptional regulation by RUNX2 99 5.28e-05 2.79e-04 0.27300 0.107000 2.51e-01 6.46e-02 1.57e-05
Oncogene Induced Senescence 33 6.27e-02 1.14e-01 0.27300 0.136000 2.36e-01 1.76e-01 1.87e-02
Acyl chain remodelling of PE 20 2.22e-01 3.16e-01 0.27300 0.223000 1.58e-01 8.47e-02 2.22e-01
Export of Viral Ribonucleoproteins from Nucleus 33 1.43e-02 3.39e-02 0.27300 -0.064400 -2.65e-01 5.22e-01 8.40e-03
BBSome-mediated cargo-targeting to cilium 22 8.02e-03 2.12e-02 0.27200 0.050800 -2.68e-01 6.80e-01 2.98e-02
Regulation of APC/C activators between G1/S and early anaphase 79 1.92e-03 6.42e-03 0.27200 0.146000 2.30e-01 2.51e-02 4.06e-04
Ephrin signaling 17 2.93e-01 3.93e-01 0.27200 0.167000 2.15e-01 2.34e-01 1.25e-01
Assembly of active LPL and LIPC lipase complexes 10 3.41e-01 4.45e-01 0.27200 0.092800 2.55e-01 6.11e-01 1.62e-01
Transport of bile salts and organic acids, metal ions and amine compounds 55 2.29e-02 4.89e-02 0.27100 0.183000 2.00e-01 1.87e-02 1.02e-02
Formation of the beta-catenin:TCF transactivating complex 46 1.99e-02 4.36e-02 0.27100 0.130000 2.38e-01 1.27e-01 5.30e-03
NRIF signals cell death from the nucleus 15 2.76e-01 3.76e-01 0.27000 0.128000 2.38e-01 3.90e-01 1.10e-01
Peptide hormone metabolism 49 9.38e-03 2.41e-02 0.27000 0.247000 1.10e-01 2.81e-03 1.83e-01
HDR through Homologous Recombination (HRR) 66 5.92e-03 1.65e-02 0.26900 -0.143000 -2.28e-01 4.42e-02 1.36e-03
NR1H2 and NR1H3-mediated signaling 38 6.03e-03 1.68e-02 0.26900 0.050800 2.64e-01 5.88e-01 4.84e-03
Complement cascade 97 1.56e-12 4.61e-11 0.26900 0.201000 -1.79e-01 6.33e-04 2.33e-03
Cohesin Loading onto Chromatin 10 4.93e-01 5.94e-01 0.26900 0.164000 2.13e-01 3.70e-01 2.43e-01
Signaling by Rho GTPases 364 9.12e-14 3.11e-12 0.26900 0.129000 2.36e-01 2.29e-05 1.15e-14
Unblocking of NMDA receptors, glutamate binding and activation 12 4.39e-01 5.41e-01 0.26800 -0.171000 -2.07e-01 3.05e-01 2.15e-01
Keratinization 33 1.11e-01 1.84e-01 0.26800 0.196000 1.83e-01 5.18e-02 6.96e-02
Regulation of IFNA signaling 12 1.00e-01 1.68e-01 0.26600 -0.026200 2.65e-01 8.75e-01 1.12e-01
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 32 1.08e-02 2.71e-02 0.26500 0.035100 2.62e-01 7.31e-01 1.02e-02
Retrograde transport at the Trans-Golgi-Network 49 1.99e-02 4.36e-02 0.26500 0.130000 2.31e-01 1.16e-01 5.24e-03
Constitutive Signaling by AKT1 E17K in Cancer 26 4.24e-03 1.25e-02 0.26500 -0.053900 2.59e-01 6.34e-01 2.23e-02
Immune System 1885 2.77e-52 1.26e-49 0.26400 0.158000 2.11e-01 4.26e-30 4.62e-52
Class I peroxisomal membrane protein import 20 4.07e-02 7.94e-02 0.26400 -0.263000 -9.67e-03 4.14e-02 9.40e-01
Elastic fibre formation 31 1.01e-01 1.69e-01 0.26400 0.142000 2.22e-01 1.72e-01 3.23e-02
Signaling by ERBB2 KD Mutants 20 1.99e-01 2.91e-01 0.26300 0.231000 1.26e-01 7.33e-02 3.29e-01
Transcriptional regulation by RUNX3 90 5.23e-04 2.08e-03 0.26300 0.119000 2.35e-01 5.11e-02 1.18e-04
Phospholipid metabolism 184 1.17e-06 1.08e-05 0.26300 0.138000 2.23e-01 1.20e-03 1.73e-07
DNA Damage/Telomere Stress Induced Senescence 44 1.50e-02 3.50e-02 0.26300 0.098000 2.44e-01 2.61e-01 5.16e-03
Postmitotic nuclear pore complex (NPC) reformation 27 7.98e-02 1.40e-01 0.26200 -0.099900 -2.42e-01 3.69e-01 2.94e-02
CaM pathway 27 8.94e-02 1.54e-01 0.26100 0.106000 2.39e-01 3.40e-01 3.17e-02
Calmodulin induced events 27 8.94e-02 1.54e-01 0.26100 0.106000 2.39e-01 3.40e-01 3.17e-02
Metabolism of folate and pterines 16 3.08e-01 4.09e-01 0.26100 0.222000 1.37e-01 1.25e-01 3.43e-01
Activation of HOX genes during differentiation 69 3.21e-04 1.37e-03 0.26000 0.062300 2.53e-01 3.71e-01 2.80e-04
Activation of anterior HOX genes in hindbrain development during early embryogenesis 69 3.21e-04 1.37e-03 0.26000 0.062300 2.53e-01 3.71e-01 2.80e-04
CD209 (DC-SIGN) signaling 20 2.56e-01 3.52e-01 0.26000 0.152000 2.12e-01 2.40e-01 1.01e-01
Metabolism of steroids 116 5.72e-05 2.99e-04 0.26000 0.113000 2.34e-01 3.49e-02 1.30e-05
Selenoamino acid metabolism 113 3.57e-04 1.49e-03 0.26000 -0.143000 -2.17e-01 8.43e-03 6.97e-05
FCERI mediated Ca+2 mobilization 88 2.55e-10 5.18e-09 0.26000 0.136000 -2.21e-01 2.78e-02 3.34e-04
Signaling by ERBB2 TMD/JMD mutants 17 2.89e-01 3.88e-01 0.25900 0.221000 1.36e-01 1.15e-01 3.30e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 2.00e-01 2.92e-01 0.25900 -0.163000 -2.01e-01 1.58e-01 8.15e-02
Cellular Senescence 144 6.90e-06 4.75e-05 0.25900 0.114000 2.32e-01 1.85e-02 1.48e-06
Signaling by NTRK2 (TRKB) 20 2.25e-01 3.19e-01 0.25800 0.223000 1.31e-01 8.42e-02 3.12e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 99 1.00e-03 3.66e-03 0.25800 -0.142000 -2.16e-01 1.48e-02 2.06e-04
FCERI mediated MAPK activation 89 2.70e-10 5.39e-09 0.25800 0.221000 -1.33e-01 3.06e-04 3.02e-02
Transport of the SLBP independent Mature mRNA 35 1.02e-02 2.59e-02 0.25800 -0.038800 -2.55e-01 6.91e-01 9.00e-03
HCMV Late Events 69 1.32e-02 3.18e-02 0.25800 0.168000 1.96e-01 1.57e-02 4.94e-03
Signaling by TGF-beta Receptor Complex 72 1.39e-03 4.85e-03 0.25800 0.096800 2.39e-01 1.56e-01 4.56e-04
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 3.67e-01 4.73e-01 0.25700 0.136000 2.18e-01 3.80e-01 1.57e-01
Ub-specific processing proteases 169 1.26e-05 7.92e-05 0.25700 0.147000 2.11e-01 1.01e-03 2.30e-06
Peroxisomal protein import 57 1.96e-02 4.33e-02 0.25700 0.141000 2.14e-01 6.55e-02 5.11e-03
PKA-mediated phosphorylation of CREB 17 2.20e-01 3.14e-01 0.25600 0.098200 2.36e-01 4.83e-01 9.17e-02
tRNA processing 136 2.02e-04 9.01e-04 0.25600 -0.161000 -1.99e-01 1.22e-03 6.13e-05
Removal of the Flap Intermediate from the C-strand 17 3.57e-01 4.63e-01 0.25500 -0.177000 -1.84e-01 2.07e-01 1.88e-01
Negative regulation of FGFR2 signaling 23 1.82e-01 2.72e-01 0.25500 0.125000 2.22e-01 2.98e-01 6.55e-02
FCGR3A-mediated phagocytosis 120 5.89e-07 5.95e-06 0.25500 0.250000 4.90e-02 2.26e-06 3.54e-01
Leishmania phagocytosis 120 5.89e-07 5.95e-06 0.25500 0.250000 4.90e-02 2.26e-06 3.54e-01
Parasite infection 120 5.89e-07 5.95e-06 0.25500 0.250000 4.90e-02 2.26e-06 3.54e-01
Downstream signal transduction 27 1.96e-01 2.89e-01 0.25400 0.168000 1.90e-01 1.31e-01 8.73e-02
DAP12 interactions 39 3.69e-02 7.31e-02 0.25400 0.102000 2.32e-01 2.69e-01 1.21e-02
RET signaling 32 9.11e-02 1.56e-01 0.25300 0.121000 2.23e-01 2.37e-01 2.93e-02
APC/C-mediated degradation of cell cycle proteins 86 2.32e-03 7.29e-03 0.25300 0.130000 2.17e-01 3.77e-02 4.98e-04
Regulation of mitotic cell cycle 86 2.32e-03 7.29e-03 0.25300 0.130000 2.17e-01 3.77e-02 4.98e-04
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 3.99e-01 5.03e-01 0.25300 -0.143000 -2.08e-01 3.55e-01 1.77e-01
Assembly of the pre-replicative complex 66 6.21e-03 1.71e-02 0.25300 0.115000 2.25e-01 1.07e-01 1.58e-03
NoRC negatively regulates rRNA expression 59 2.99e-02 6.15e-02 0.25200 0.169000 1.87e-01 2.48e-02 1.27e-02
Plasma lipoprotein remodeling 18 1.89e-01 2.79e-01 0.25200 0.086800 2.37e-01 5.24e-01 8.17e-02
ABC transporters in lipid homeostasis 14 4.37e-01 5.39e-01 0.25200 -0.176000 -1.81e-01 2.54e-01 2.41e-01
Signaling by FGFR4 in disease 11 1.77e-01 2.66e-01 0.25200 0.252000 -5.66e-03 1.48e-01 9.74e-01
Transport of small molecules 554 6.00e-15 3.03e-13 0.25000 0.154000 1.96e-01 5.35e-10 2.54e-15
Influenza Viral RNA Transcription and Replication 134 2.59e-04 1.13e-03 0.25000 -0.148000 -2.01e-01 3.09e-03 5.90e-05
Metabolism of lipids 619 2.02e-20 1.97e-18 0.24900 0.113000 2.22e-01 1.62e-06 3.83e-21
Signaling by Hedgehog 119 1.17e-04 5.58e-04 0.24900 0.110000 2.23e-01 3.80e-02 2.61e-05
Glycosaminoglycan metabolism 92 1.53e-05 9.32e-05 0.24800 0.038200 2.45e-01 5.26e-01 4.75e-05
FRS-mediated FGFR1 signaling 14 3.61e-01 4.66e-01 0.24800 0.219000 1.16e-01 1.56e-01 4.52e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 5.36e-01 6.31e-01 0.24700 0.176000 1.74e-01 3.13e-01 3.18e-01
PIP3 activates AKT signaling 239 3.36e-09 5.51e-08 0.24700 0.095800 2.28e-01 1.08e-02 1.32e-09
Regulation of PTEN gene transcription 59 3.84e-03 1.15e-02 0.24700 0.075400 2.35e-01 3.16e-01 1.78e-03
Meiotic synapsis 45 5.57e-02 1.04e-01 0.24700 0.135000 2.07e-01 1.18e-01 1.64e-02
Deubiquitination 240 3.64e-08 4.86e-07 0.24600 0.115000 2.18e-01 2.16e-03 5.99e-09
Fcgamma receptor (FCGR) dependent phagocytosis 146 1.58e-06 1.43e-05 0.24600 0.233000 7.84e-02 1.11e-06 1.02e-01
Metabolism of non-coding RNA 53 1.19e-03 4.23e-03 0.24600 -0.025600 -2.45e-01 7.48e-01 2.07e-03
snRNP Assembly 53 1.19e-03 4.23e-03 0.24600 -0.025600 -2.45e-01 7.48e-01 2.07e-03
Negative regulation of MAPK pathway 42 8.70e-03 2.27e-02 0.24600 0.045600 2.42e-01 6.09e-01 6.75e-03
Negative regulation of NMDA receptor-mediated neuronal transmission 14 4.48e-01 5.50e-01 0.24500 -0.157000 -1.89e-01 3.09e-01 2.22e-01
MHC class II antigen presentation 101 3.43e-04 1.45e-03 0.24500 0.098700 2.24e-01 8.66e-02 9.66e-05
VEGFR2 mediated cell proliferation 18 3.42e-01 4.46e-01 0.24500 0.145000 1.97e-01 2.86e-01 1.47e-01
Signaling by FGFR1 38 8.61e-02 1.50e-01 0.24300 0.126000 2.08e-01 1.77e-01 2.68e-02
RUNX3 regulates NOTCH signaling 14 2.87e-01 3.86e-01 0.24300 0.077700 2.30e-01 6.15e-01 1.36e-01
HCMV Infection 96 4.71e-03 1.36e-02 0.24300 0.156000 1.86e-01 8.23e-03 1.64e-03
Formation of a pool of free 40S subunits 99 1.98e-03 6.58e-03 0.24300 -0.130000 -2.05e-01 2.56e-02 4.19e-04
Stimuli-sensing channels 72 1.99e-02 4.36e-02 0.24200 0.174000 1.68e-01 1.06e-02 1.35e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 2.11e-01 3.03e-01 0.24200 0.104000 2.19e-01 4.12e-01 8.25e-02
Downregulation of ERBB2 signaling 24 1.36e-01 2.15e-01 0.24200 0.086500 2.26e-01 4.63e-01 5.52e-02
Signaling by TGFB family members 91 4.35e-03 1.27e-02 0.24200 0.138000 1.99e-01 2.32e-02 1.03e-03
Triglyceride metabolism 25 2.14e-01 3.07e-01 0.24200 0.132000 2.03e-01 2.52e-01 7.96e-02
p75 NTR receptor-mediated signalling 88 1.50e-03 5.15e-03 0.24100 0.102000 2.19e-01 9.72e-02 3.92e-04
Arachidonic acid metabolism 42 5.00e-02 9.49e-02 0.24100 0.106000 2.16e-01 2.33e-01 1.56e-02
Mitochondrial biogenesis 88 7.30e-03 1.97e-02 0.24000 0.147000 1.89e-01 1.69e-02 2.12e-03
Platelet calcium homeostasis 21 2.90e-02 6.00e-02 0.23900 -0.043600 2.35e-01 7.29e-01 6.19e-02
Intracellular signaling by second messengers 271 5.16e-10 9.38e-09 0.23900 0.088400 2.22e-01 1.23e-02 2.91e-10
SUMOylation of transcription factors 16 3.72e-01 4.77e-01 0.23900 0.126000 2.03e-01 3.84e-01 1.59e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 2.08e-01 3.00e-01 0.23900 0.023700 2.38e-01 8.82e-01 1.38e-01
N-glycan antennae elongation in the medial/trans-Golgi 21 2.00e-02 4.37e-02 0.23800 -0.227000 7.33e-02 7.20e-02 5.61e-01
Potential therapeutics for SARS 78 4.28e-03 1.26e-02 0.23800 0.104000 2.13e-01 1.12e-01 1.11e-03
Ion channel transport 133 5.02e-04 2.01e-03 0.23700 0.135000 1.95e-01 7.32e-03 1.05e-04
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 83 2.23e-08 3.13e-07 0.23700 0.134000 -1.96e-01 3.54e-02 2.07e-03
Extracellular matrix organization 215 1.18e-05 7.47e-05 0.23700 0.152000 1.81e-01 1.22e-04 4.54e-06
Metabolism of cofactors 19 3.20e-01 4.22e-01 0.23600 0.125000 2.00e-01 3.46e-01 1.31e-01
Class I MHC mediated antigen processing & presentation 347 1.00e-11 2.74e-10 0.23600 0.093700 2.17e-01 2.72e-03 4.12e-12
Transport of the SLBP Dependant Mature mRNA 36 1.16e-02 2.87e-02 0.23600 -0.014800 -2.35e-01 8.78e-01 1.45e-02
Hedgehog 'off' state 91 9.82e-04 3.63e-03 0.23600 0.089200 2.18e-01 1.41e-01 3.18e-04
Carboxyterminal post-translational modifications of tubulin 26 9.98e-02 1.68e-01 0.23600 0.067600 2.26e-01 5.51e-01 4.63e-02
Metabolism of nucleotides 86 1.35e-03 4.75e-03 0.23600 0.219000 8.76e-02 4.53e-04 1.60e-01
mRNA decay by 3' to 5' exoribonuclease 16 3.07e-01 4.07e-01 0.23500 -0.092300 -2.16e-01 5.23e-01 1.35e-01
Insulin processing 20 3.59e-01 4.65e-01 0.23500 0.169000 1.63e-01 1.90e-01 2.07e-01
Vitamin B5 (pantothenate) metabolism 17 4.12e-01 5.15e-01 0.23400 0.151000 1.79e-01 2.81e-01 2.00e-01
Retinoid metabolism and transport 24 1.62e-01 2.47e-01 0.23400 0.087800 2.17e-01 4.57e-01 6.53e-02
Cyclin E associated events during G1/S transition 83 4.07e-03 1.21e-02 0.23400 0.106000 2.09e-01 9.41e-02 1.01e-03
HS-GAG biosynthesis 20 1.19e-01 1.93e-01 0.23400 0.037900 2.31e-01 7.69e-01 7.35e-02
Metabolism of fat-soluble vitamins 28 1.51e-01 2.33e-01 0.23400 0.103000 2.10e-01 3.46e-01 5.47e-02
Insulin receptor signalling cascade 39 1.42e-01 2.22e-01 0.23200 0.164000 1.65e-01 7.64e-02 7.52e-02
Mismatch Repair 15 3.80e-01 4.85e-01 0.23200 -0.106000 -2.06e-01 4.77e-01 1.67e-01
NCAM1 interactions 23 1.12e-01 1.86e-01 0.23100 -0.050800 -2.26e-01 6.73e-01 6.10e-02
Downstream signaling of activated FGFR3 16 2.84e-01 3.83e-01 0.23100 0.218000 7.76e-02 1.31e-01 5.91e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 5.16e-01 6.15e-01 0.23100 0.129000 1.91e-01 4.39e-01 2.51e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 2.30e-01 3.25e-01 0.23000 -0.185000 -1.38e-01 9.09e-02 2.07e-01
Resolution of D-Loop Structures 33 1.98e-01 2.91e-01 0.23000 -0.161000 -1.64e-01 1.09e-01 1.03e-01
Circadian Clock 67 3.13e-03 9.64e-03 0.23000 0.062900 2.21e-01 3.73e-01 1.74e-03
Downregulation of TGF-beta receptor signaling 26 5.99e-02 1.10e-01 0.23000 0.028300 2.28e-01 8.03e-01 4.40e-02
Interconversion of nucleotide di- and triphosphates 27 8.60e-02 1.50e-01 0.23000 0.223000 5.51e-02 4.48e-02 6.20e-01
Translation of structural proteins 28 8.61e-03 2.26e-02 0.23000 -0.065600 2.20e-01 5.48e-01 4.40e-02
Intrinsic Pathway for Apoptosis 53 5.52e-02 1.04e-01 0.22900 0.127000 1.91e-01 1.10e-01 1.63e-02
Apoptotic cleavage of cellular proteins 34 1.52e-01 2.34e-01 0.22900 0.125000 1.92e-01 2.08e-01 5.25e-02
Cell junction organization 59 4.53e-02 8.69e-02 0.22900 0.186000 1.34e-01 1.37e-02 7.53e-02
Cell surface interactions at the vascular wall 172 5.16e-08 6.64e-07 0.22900 0.225000 4.18e-02 3.63e-07 3.44e-01
Maturation of nucleoprotein 10 4.92e-01 5.93e-01 0.22800 -0.211000 -8.77e-02 2.48e-01 6.31e-01
Metabolism of carbohydrates 241 1.94e-08 2.79e-07 0.22800 0.081000 2.13e-01 3.03e-02 1.14e-08
Adrenaline,noradrenaline inhibits insulin secretion 24 3.04e-01 4.04e-01 0.22800 0.176000 1.45e-01 1.36e-01 2.18e-01
Signaling by PDGFR in disease 19 3.96e-01 5.01e-01 0.22800 0.171000 1.51e-01 1.98e-01 2.54e-01
NOTCH2 intracellular domain regulates transcription 11 5.89e-01 6.77e-01 0.22600 0.169000 1.50e-01 3.31e-01 3.88e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 2.07e-01 3.00e-01 0.22600 -0.142000 -1.76e-01 1.63e-01 8.51e-02
Formation of RNA Pol II elongation complex 57 2.23e-03 7.10e-03 0.22600 0.024200 2.25e-01 7.52e-01 3.30e-03
RNA Polymerase II Transcription Elongation 57 2.23e-03 7.10e-03 0.22600 0.024200 2.25e-01 7.52e-01 3.30e-03
Unfolded Protein Response (UPR) 87 5.71e-03 1.60e-02 0.22600 0.108000 1.99e-01 8.15e-02 1.37e-03
Glutathione conjugation 26 2.90e-01 3.88e-01 0.22600 0.153000 1.67e-01 1.78e-01 1.42e-01
Factors involved in megakaryocyte development and platelet production 116 2.12e-03 6.95e-03 0.22500 0.124000 1.88e-01 2.15e-02 4.57e-04
Elevation of cytosolic Ca2+ levels 12 1.30e-01 2.08e-01 0.22500 -0.076600 2.11e-01 6.46e-01 2.05e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.44e-01 3.40e-01 0.22400 -0.186000 -1.25e-01 9.38e-02 2.60e-01
FCGR3A-mediated IL10 synthesis 98 8.66e-09 1.33e-07 0.22400 0.124000 -1.87e-01 3.37e-02 1.40e-03
Termination of translesion DNA synthesis 32 8.42e-02 1.47e-01 0.22400 -0.069200 -2.13e-01 4.98e-01 3.69e-02
MET activates PTK2 signaling 15 3.76e-01 4.80e-01 0.22400 0.204000 9.22e-02 1.71e-01 5.36e-01
Synthesis of PIPs at the plasma membrane 52 4.81e-03 1.39e-02 0.22400 0.027800 2.22e-01 7.29e-01 5.54e-03
Other semaphorin interactions 16 4.16e-01 5.18e-01 0.22400 0.117000 1.91e-01 4.20e-01 1.85e-01
TNFs bind their physiological receptors 25 1.15e-02 2.85e-02 0.22400 0.097000 -2.02e-01 4.01e-01 8.11e-02
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 113 4.86e-03 1.39e-02 0.22300 -0.144000 -1.71e-01 8.12e-03 1.72e-03
Nonsense-Mediated Decay (NMD) 113 4.86e-03 1.39e-02 0.22300 -0.144000 -1.71e-01 8.12e-03 1.72e-03
MAPK1/MAPK3 signaling 233 7.58e-07 7.33e-06 0.22300 0.099300 2.00e-01 9.02e-03 1.52e-07
TNFR2 non-canonical NF-kB pathway 95 1.16e-02 2.87e-02 0.22300 0.170000 1.43e-01 4.10e-03 1.59e-02
Nef mediated downregulation of MHC class I complex cell surface expression 10 4.26e-01 5.29e-01 0.22200 0.052800 2.16e-01 7.73e-01 2.37e-01
Leishmania infection 243 2.02e-06 1.73e-05 0.22200 0.191000 1.14e-01 3.05e-07 2.20e-03
Signaling by WNT in cancer 30 5.11e-03 1.46e-02 0.22200 -0.095900 2.00e-01 3.63e-01 5.76e-02
MAPK family signaling cascades 267 6.89e-07 6.71e-06 0.22100 0.114000 1.89e-01 1.29e-03 1.00e-07
Signaling by ERBB2 ECD mutants 15 4.69e-01 5.71e-01 0.22000 0.183000 1.22e-01 2.19e-01 4.12e-01
Neurotransmitter receptors and postsynaptic signal transmission 123 2.27e-03 7.21e-03 0.21800 0.121000 1.82e-01 2.02e-02 4.99e-04
Neddylation 217 6.19e-07 6.12e-06 0.21800 0.080500 2.03e-01 4.10e-02 2.57e-07
Transcriptional regulation by RUNX1 184 3.25e-06 2.56e-05 0.21800 0.074200 2.05e-01 8.24e-02 1.69e-06
Degradation of cysteine and homocysteine 12 2.89e-01 3.88e-01 0.21800 0.016700 2.17e-01 9.20e-01 1.93e-01
FLT3 Signaling 242 4.37e-07 4.68e-06 0.21700 0.089500 1.98e-01 1.65e-02 1.16e-07
Keratan sulfate biosynthesis 20 3.26e-02 6.60e-02 0.21700 -0.192000 1.01e-01 1.36e-01 4.36e-01
Mitochondrial calcium ion transport 22 3.42e-01 4.46e-01 0.21700 0.180000 1.21e-01 1.44e-01 3.25e-01
Disorders of transmembrane transporters 144 1.02e-03 3.71e-03 0.21700 0.123000 1.78e-01 1.07e-02 2.20e-04
RAS processing 19 1.38e-01 2.18e-01 0.21600 0.013300 2.16e-01 9.20e-01 1.04e-01
Keratan sulfate/keratin metabolism 25 4.73e-02 9.04e-02 0.21600 -0.015200 2.15e-01 8.95e-01 6.24e-02
Heparan sulfate/heparin (HS-GAG) metabolism 37 1.07e-02 2.71e-02 0.21600 -0.016800 2.15e-01 8.60e-01 2.37e-02
Post-translational protein modification 1183 2.92e-28 4.42e-26 0.21500 0.097100 1.92e-01 1.84e-08 7.00e-29
Signaling by FGFR in disease 50 1.15e-01 1.88e-01 0.21500 0.159000 1.45e-01 5.12e-02 7.63e-02
FCERI mediated NF-kB activation 136 2.60e-06 2.11e-05 0.21500 0.213000 2.58e-02 1.74e-05 6.04e-01
HIV Transcription Initiation 45 1.13e-01 1.86e-01 0.21500 0.117000 1.80e-01 1.73e-01 3.70e-02
RNA Polymerase II HIV Promoter Escape 45 1.13e-01 1.86e-01 0.21500 0.117000 1.80e-01 1.73e-01 3.70e-02
RNA Polymerase II Promoter Escape 45 1.13e-01 1.86e-01 0.21500 0.117000 1.80e-01 1.73e-01 3.70e-02
RNA Polymerase II Transcription Initiation 45 1.13e-01 1.86e-01 0.21500 0.117000 1.80e-01 1.73e-01 3.70e-02
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 1.13e-01 1.86e-01 0.21500 0.117000 1.80e-01 1.73e-01 3.70e-02
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 1.13e-01 1.86e-01 0.21500 0.117000 1.80e-01 1.73e-01 3.70e-02
Cyclin A:Cdk2-associated events at S phase entry 85 5.90e-03 1.65e-02 0.21400 0.085400 1.96e-01 1.73e-01 1.78e-03
Signaling by PDGF 44 1.47e-01 2.28e-01 0.21400 0.165000 1.36e-01 5.86e-02 1.18e-01
Tight junction interactions 18 6.42e-02 1.16e-01 0.21300 0.200000 -7.29e-02 1.42e-01 5.92e-01
Dectin-2 family 19 3.95e-01 5.01e-01 0.21200 0.112000 1.81e-01 3.99e-01 1.73e-01
Fc epsilon receptor (FCERI) signaling 189 1.33e-05 8.31e-05 0.21100 0.194000 8.32e-02 4.04e-06 4.86e-02
RAF/MAP kinase cascade 228 2.10e-06 1.78e-05 0.21100 0.087300 1.92e-01 2.32e-02 5.48e-07
Cellular responses to external stimuli 503 9.71e-11 2.20e-09 0.21100 0.116000 1.77e-01 9.00e-06 1.18e-11
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 79 2.56e-02 5.39e-02 0.21000 0.115000 1.76e-01 7.62e-02 6.85e-03
Phase 4 - resting membrane potential 10 6.21e-01 7.03e-01 0.21000 0.178000 1.11e-01 3.29e-01 5.45e-01
Biosynthesis of DHA-derived SPMs 14 5.55e-01 6.47e-01 0.20900 0.130000 1.63e-01 3.99e-01 2.91e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 4.74e-01 5.75e-01 0.20800 0.191000 8.30e-02 2.34e-01 6.04e-01
Downstream signaling of activated FGFR4 17 3.14e-01 4.16e-01 0.20800 0.198000 6.10e-02 1.57e-01 6.63e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 7.22e-02 1.28e-01 0.20700 -0.071000 -1.95e-01 4.26e-01 2.89e-02
RNA Pol II CTD phosphorylation and interaction with CE 27 1.39e-01 2.18e-01 0.20700 0.051200 2.01e-01 6.45e-01 7.07e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 1.39e-01 2.18e-01 0.20700 0.051200 2.01e-01 6.45e-01 7.07e-02
Signaling by ERBB2 44 9.31e-02 1.59e-01 0.20700 0.088500 1.87e-01 3.10e-01 3.20e-02
Fatty acid metabolism 150 9.61e-04 3.58e-03 0.20600 0.107000 1.76e-01 2.36e-02 1.93e-04
Cellular responses to stress 497 3.56e-10 6.75e-09 0.20600 0.113000 1.73e-01 1.71e-05 4.43e-11
G alpha (12/13) signalling events 68 5.92e-02 1.09e-01 0.20600 0.125000 1.64e-01 7.53e-02 1.94e-02
Phase 2 - plateau phase 11 5.03e-01 6.02e-01 0.20600 -0.068700 -1.94e-01 6.93e-01 2.66e-01
PI-3K cascade:FGFR4 10 4.79e-01 5.80e-01 0.20500 0.200000 4.77e-02 2.74e-01 7.94e-01
Formation of the Early Elongation Complex 33 2.70e-02 5.64e-02 0.20500 -0.012800 2.05e-01 8.99e-01 4.15e-02
Formation of the HIV-1 Early Elongation Complex 33 2.70e-02 5.64e-02 0.20500 -0.012800 2.05e-01 8.99e-01 4.15e-02
tRNA Aminoacylation 42 7.52e-02 1.33e-01 0.20500 -0.069700 -1.93e-01 4.35e-01 3.04e-02
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 4.84e-02 9.23e-02 0.20500 -0.033400 2.02e-01 7.72e-01 8.04e-02
Negative epigenetic regulation of rRNA expression 62 9.10e-02 1.56e-01 0.20400 0.143000 1.46e-01 5.20e-02 4.65e-02
Regulation of pyruvate dehydrogenase (PDH) complex 15 5.48e-01 6.40e-01 0.20400 0.159000 1.28e-01 2.87e-01 3.89e-01
Metabolic disorders of biological oxidation enzymes 23 2.68e-01 3.66e-01 0.20300 0.075400 1.89e-01 5.31e-01 1.17e-01
Fatty acyl-CoA biosynthesis 33 2.62e-01 3.60e-01 0.20300 0.121000 1.62e-01 2.28e-01 1.06e-01
Signaling by FGFR2 IIIa TM 18 2.70e-01 3.68e-01 0.20200 0.044300 1.97e-01 7.45e-01 1.47e-01
Collagen formation 64 3.66e-02 7.25e-02 0.20200 0.085700 1.83e-01 2.36e-01 1.14e-02
MECP2 regulates neuronal receptors and channels 13 1.38e-01 2.18e-01 0.20100 -0.109000 1.69e-01 4.94e-01 2.93e-01
TP53 Regulates Transcription of Cell Death Genes 43 1.70e-01 2.59e-01 0.20000 0.165000 1.13e-01 6.09e-02 1.98e-01
RUNX3 regulates p14-ARF 10 4.55e-01 5.57e-01 0.20000 0.030800 1.98e-01 8.66e-01 2.79e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 4.06e-01 5.09e-01 0.20000 -0.183000 -7.90e-02 1.91e-01 5.73e-01
RNA Polymerase II Pre-transcription Events 78 7.73e-03 2.06e-02 0.19900 0.059100 1.90e-01 3.67e-01 3.63e-03
Synthesis of substrates in N-glycan biosythesis 58 9.47e-02 1.61e-01 0.19800 0.111000 1.64e-01 1.42e-01 3.04e-02
Defects in cobalamin (B12) metabolism 13 3.49e-01 4.55e-01 0.19800 -0.024000 -1.97e-01 8.81e-01 2.19e-01
Signaling by FGFR3 in disease 13 1.86e-01 2.77e-01 0.19800 0.189000 -6.14e-02 2.39e-01 7.02e-01
Signaling by FGFR3 point mutants in cancer 13 1.86e-01 2.77e-01 0.19800 0.189000 -6.14e-02 2.39e-01 7.02e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 8.76e-03 2.27e-02 0.19800 -0.031200 1.96e-01 7.27e-01 2.81e-02
HIV Transcription Elongation 42 8.76e-03 2.27e-02 0.19800 -0.031200 1.96e-01 7.27e-01 2.81e-02
Tat-mediated elongation of the HIV-1 transcript 42 8.76e-03 2.27e-02 0.19800 -0.031200 1.96e-01 7.27e-01 2.81e-02
Signal Transduction 1869 1.00e-35 2.74e-33 0.19800 0.090300 1.76e-01 1.01e-10 2.34e-36
Ca2+ pathway 57 9.73e-02 1.64e-01 0.19800 0.165000 1.08e-01 3.11e-02 1.57e-01
Processing and activation of SUMO 10 6.91e-01 7.64e-01 0.19700 0.151000 1.27e-01 4.08e-01 4.86e-01
Metabolism 1758 1.90e-30 3.71e-28 0.19700 0.103000 1.68e-01 5.85e-13 1.29e-31
RAF-independent MAPK1/3 activation 21 3.50e-01 4.55e-01 0.19700 0.081700 1.79e-01 5.17e-01 1.55e-01
Rho GTPase cycle 125 9.48e-04 3.54e-03 0.19700 0.068000 1.84e-01 1.89e-01 3.69e-04
RNA Polymerase I Transcription Initiation 44 2.04e-01 2.96e-01 0.19600 -0.131000 -1.47e-01 1.34e-01 9.20e-02
Mitotic Prophase 98 2.91e-02 6.01e-02 0.19600 0.129000 1.48e-01 2.76e-02 1.14e-02
RNA Polymerase III Chain Elongation 18 4.98e-01 5.98e-01 0.19600 -0.160000 -1.13e-01 2.41e-01 4.05e-01
HIV Infection 224 3.25e-05 1.79e-04 0.19600 0.088300 1.75e-01 2.28e-02 6.70e-06
Influenza Infection 153 3.42e-03 1.04e-02 0.19500 -0.118000 -1.55e-01 1.17e-02 9.20e-04
Cobalamin (Cbl, vitamin B12) transport and metabolism 17 3.82e-01 4.87e-01 0.19400 -0.062900 -1.84e-01 6.53e-01 1.90e-01
Antiviral mechanism by IFN-stimulated genes 80 5.84e-02 1.08e-01 0.19400 -0.125000 -1.48e-01 5.24e-02 2.23e-02
Zinc transporters 14 6.14e-01 6.97e-01 0.19400 0.140000 1.34e-01 3.64e-01 3.87e-01
Transcriptional Regulation by E2F6 34 1.25e-01 2.00e-01 0.19400 -0.052600 -1.86e-01 5.95e-01 6.01e-02
Bile acid and bile salt metabolism 28 2.31e-01 3.25e-01 0.19400 0.071200 1.80e-01 5.14e-01 9.93e-02
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 2.51e-01 3.47e-01 0.19200 0.035200 1.89e-01 7.85e-01 1.44e-01
Trafficking of AMPA receptors 20 2.51e-01 3.47e-01 0.19200 0.035200 1.89e-01 7.85e-01 1.44e-01
HS-GAG degradation 16 4.39e-01 5.41e-01 0.19200 0.070200 1.78e-01 6.27e-01 2.16e-01
Regulation of MECP2 expression and activity 28 9.67e-02 1.64e-01 0.19100 0.008330 1.91e-01 9.39e-01 8.01e-02
RNA polymerase II transcribes snRNA genes 72 2.60e-02 5.47e-02 0.19100 0.070900 1.78e-01 2.98e-01 9.17e-03
Meiotic recombination 38 2.63e-01 3.61e-01 0.19100 0.149000 1.19e-01 1.12e-01 2.03e-01
Interferon gamma signaling 83 2.94e-02 6.07e-02 0.19100 -0.168000 -9.09e-02 8.20e-03 1.52e-01
Metabolism of proteins 1706 1.53e-28 2.61e-26 0.19100 0.096700 1.65e-01 3.22e-11 1.16e-29
Formation of HIV elongation complex in the absence of HIV Tat 44 9.38e-03 2.41e-02 0.19100 -0.033200 1.88e-01 7.03e-01 3.11e-02
Purine catabolism 16 5.20e-01 6.17e-01 0.19100 0.165000 9.57e-02 2.54e-01 5.08e-01
Orc1 removal from chromatin 69 5.13e-02 9.71e-02 0.19000 0.088000 1.69e-01 2.06e-01 1.55e-02
Metal ion SLC transporters 21 4.95e-01 5.95e-01 0.19000 0.136000 1.33e-01 2.82e-01 2.91e-01
FOXO-mediated transcription 59 3.31e-02 6.67e-02 0.18900 0.053000 1.82e-01 4.82e-01 1.58e-02
Chemokine receptors bind chemokines 39 2.43e-01 3.39e-01 0.18900 -0.109000 -1.55e-01 2.39e-01 9.47e-02
HSF1-dependent transactivation 29 2.57e-01 3.53e-01 0.18800 0.075500 1.73e-01 4.82e-01 1.08e-01
Prolactin receptor signaling 11 5.43e-01 6.34e-01 0.18800 0.180000 5.62e-02 3.02e-01 7.47e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 5.72e-01 6.62e-01 0.18800 0.134000 1.32e-01 3.39e-01 3.45e-01
Cell-Cell communication 88 5.62e-02 1.04e-01 0.18800 0.136000 1.30e-01 2.80e-02 3.47e-02
Synthesis of PE 12 5.37e-01 6.32e-01 0.18800 -0.063600 -1.77e-01 7.03e-01 2.89e-01
SUMOylation of SUMOylation proteins 35 1.46e-01 2.28e-01 0.18700 -0.055700 -1.79e-01 5.68e-01 6.73e-02
Transport of Mature mRNAs Derived from Intronless Transcripts 43 8.56e-02 1.49e-01 0.18700 -0.050100 -1.80e-01 5.69e-01 4.14e-02
PI Metabolism 79 1.92e-03 6.42e-03 0.18600 0.007670 1.86e-01 9.06e-01 4.24e-03
Transmission across Chemical Synapses 170 3.63e-03 1.10e-02 0.18600 0.117000 1.45e-01 8.33e-03 1.14e-03
Interferon Signaling 177 1.99e-03 6.59e-03 0.18600 -0.153000 -1.05e-01 4.45e-04 1.55e-02
Interleukin-20 family signaling 17 5.80e-01 6.69e-01 0.18600 0.129000 1.33e-01 3.56e-01 3.42e-01
Establishment of Sister Chromatid Cohesion 11 5.00e-01 5.99e-01 0.18500 0.182000 3.66e-02 2.97e-01 8.33e-01
Death Receptor Signalling 131 6.12e-03 1.69e-02 0.18500 0.091200 1.61e-01 7.16e-02 1.44e-03
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 3.09e-02 6.33e-02 0.18500 -0.026600 1.83e-01 7.82e-01 5.78e-02
Cytosolic sulfonation of small molecules 18 3.11e-01 4.11e-01 0.18500 0.031900 1.82e-01 8.15e-01 1.82e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 2.39e-01 3.34e-01 0.18400 0.018600 1.83e-01 8.86e-01 1.56e-01
Transport of vitamins, nucleosides, and related molecules 32 8.17e-02 1.43e-01 0.18200 0.003060 1.82e-01 9.76e-01 7.47e-02
Protein methylation 15 5.67e-01 6.57e-01 0.18100 0.087700 1.58e-01 5.57e-01 2.88e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 181 2.01e-04 8.97e-04 0.18100 -0.062100 -1.70e-01 1.50e-01 8.33e-05
Protein localization 157 2.13e-03 6.95e-03 0.18000 0.081100 1.61e-01 7.96e-02 5.13e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 2.36e-01 3.31e-01 0.18000 -0.092100 1.55e-01 5.81e-01 3.54e-01
Disease 1339 2.21e-19 2.01e-17 0.17900 0.097100 1.51e-01 2.52e-09 1.99e-20
O-linked glycosylation of mucins 46 1.86e-01 2.77e-01 0.17900 0.088400 1.56e-01 3.00e-01 6.73e-02
Repression of WNT target genes 14 5.84e-01 6.72e-01 0.17900 -0.159000 -8.25e-02 3.03e-01 5.93e-01
Miscellaneous transport and binding events 20 5.28e-01 6.24e-01 0.17900 0.105000 1.44e-01 4.14e-01 2.63e-01
Developmental Biology 726 1.61e-13 5.35e-12 0.17900 0.072300 1.63e-01 9.06e-04 6.48e-14
CTLA4 inhibitory signaling 21 1.19e-01 1.93e-01 0.17700 -0.169000 5.21e-02 1.81e-01 6.79e-01
Assembly and cell surface presentation of NMDA receptors 18 1.93e-01 2.86e-01 0.17600 0.031900 -1.73e-01 8.15e-01 2.03e-01
Glycolysis 66 1.46e-01 2.28e-01 0.17600 0.132000 1.16e-01 6.30e-02 1.02e-01
Aflatoxin activation and detoxification 14 6.57e-01 7.37e-01 0.17600 0.138000 1.09e-01 3.71e-01 4.79e-01
Synthesis of bile acids and bile salts 24 3.70e-01 4.76e-01 0.17600 0.069100 1.62e-01 5.58e-01 1.70e-01
Potassium Channels 63 1.58e-01 2.42e-01 0.17600 0.135000 1.13e-01 6.41e-02 1.22e-01
Acyl chain remodelling of PS 14 5.92e-01 6.79e-01 0.17500 0.156000 7.81e-02 3.11e-01 6.13e-01
Processing of SMDT1 15 5.37e-01 6.32e-01 0.17400 0.161000 6.68e-02 2.80e-01 6.54e-01
Amino acid transport across the plasma membrane 23 5.17e-01 6.15e-01 0.17400 0.133000 1.13e-01 2.71e-01 3.50e-01
Nuclear Pore Complex (NPC) Disassembly 36 1.09e-01 1.81e-01 0.17400 -0.022000 -1.73e-01 8.19e-01 7.32e-02
Infectious disease 773 2.73e-10 5.39e-09 0.17400 0.106000 1.38e-01 5.11e-07 7.52e-11
PERK regulates gene expression 31 1.50e-01 2.32e-01 0.17300 0.172000 2.17e-02 9.79e-02 8.35e-01
Recognition of DNA damage by PCNA-containing replication complex 30 3.45e-01 4.49e-01 0.17300 -0.080600 -1.53e-01 4.45e-01 1.47e-01
HSF1 activation 26 4.80e-01 5.80e-01 0.17300 0.131000 1.12e-01 2.46e-01 3.22e-01
Formation of TC-NER Pre-Incision Complex 53 7.39e-02 1.31e-01 0.17200 0.045300 1.66e-01 5.69e-01 3.63e-02
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 3.23e-01 4.26e-01 0.17200 -0.010100 -1.72e-01 9.43e-01 2.20e-01
Muscle contraction 135 7.75e-03 2.06e-02 0.17100 0.075400 1.54e-01 1.30e-01 2.07e-03
DAG and IP3 signaling 33 2.06e-01 2.99e-01 0.17100 0.046300 1.65e-01 6.45e-01 1.02e-01
Long-term potentiation 14 5.51e-01 6.43e-01 0.17100 -0.058300 -1.60e-01 7.06e-01 2.99e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 2.97e-01 3.97e-01 0.17000 0.139000 -9.84e-02 4.25e-01 5.72e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 1.41e-01 2.21e-01 0.17000 0.123000 1.17e-01 6.86e-02 8.37e-02
Transcriptional Regulation by MECP2 47 6.91e-02 1.24e-01 0.17000 0.025200 1.68e-01 7.65e-01 4.65e-02
Nuclear Envelope (NE) Reassembly 69 4.22e-02 8.20e-02 0.17000 0.048500 1.63e-01 4.86e-01 1.96e-02
Assembly of collagen fibrils and other multimeric structures 42 3.21e-01 4.23e-01 0.16900 0.110000 1.29e-01 2.17e-01 1.49e-01
Telomere Extension By Telomerase 23 3.16e-01 4.17e-01 0.16900 -0.165000 -3.87e-02 1.71e-01 7.48e-01
SLBP independent Processing of Histone Pre-mRNAs 10 3.64e-01 4.70e-01 0.16900 0.070300 -1.54e-01 7.00e-01 4.00e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 1.22e-01 1.97e-01 0.16900 0.126000 -1.12e-01 3.40e-01 3.98e-01
ECM proteoglycans 34 3.75e-01 4.80e-01 0.16800 0.094800 1.38e-01 3.39e-01 1.63e-01
Dual Incision in GG-NER 41 2.72e-01 3.71e-01 0.16700 -0.082500 -1.45e-01 3.61e-01 1.07e-01
Downregulation of ERBB2:ERBB3 signaling 12 5.06e-01 6.04e-01 0.16700 0.021500 1.66e-01 8.97e-01 3.20e-01
Positive epigenetic regulation of rRNA expression 59 2.18e-01 3.12e-01 0.16700 0.118000 1.18e-01 1.17e-01 1.16e-01
Signaling by NOTCH2 30 3.05e-01 4.06e-01 0.16600 0.058900 1.56e-01 5.77e-01 1.40e-01
Antigen processing: Ubiquitination & Proteasome degradation 286 3.40e-06 2.65e-05 0.16600 0.045900 1.59e-01 1.82e-01 3.58e-06
Interleukin-37 signaling 19 1.32e-01 2.10e-01 0.16600 -0.113000 1.21e-01 3.92e-01 3.62e-01
Cholesterol biosynthesis 24 1.49e-01 2.31e-01 0.16600 -0.027300 1.63e-01 8.17e-01 1.66e-01
Negative regulation of the PI3K/AKT network 86 4.67e-02 8.95e-02 0.16500 0.066700 1.51e-01 2.85e-01 1.56e-02
Synthesis of PIPs at the Golgi membrane 16 4.14e-01 5.18e-01 0.16500 0.021700 1.63e-01 8.81e-01 2.58e-01
PI-3K cascade:FGFR1 12 6.74e-01 7.51e-01 0.16400 0.147000 7.40e-02 3.79e-01 6.57e-01
Regulation of FOXO transcriptional activity by acetylation 10 6.00e-01 6.86e-01 0.16400 0.029100 1.62e-01 8.73e-01 3.76e-01
SHC-mediated cascade:FGFR4 10 6.89e-01 7.62e-01 0.16400 0.152000 6.11e-02 4.04e-01 7.38e-01
GTP hydrolysis and joining of the 60S ribosomal subunit 110 1.76e-02 3.94e-02 0.16400 -0.061900 -1.52e-01 2.62e-01 5.96e-03
NOTCH4 Intracellular Domain Regulates Transcription 17 2.27e-01 3.22e-01 0.16400 -0.048900 1.56e-01 7.27e-01 2.65e-01
Glucose metabolism 83 9.07e-02 1.56e-01 0.16300 0.085600 1.39e-01 1.77e-01 2.84e-02
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 2.37e-01 3.32e-01 0.16300 -0.124000 1.05e-01 4.21e-01 4.96e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 2.37e-01 3.32e-01 0.16300 -0.124000 1.05e-01 4.21e-01 4.96e-01
Axon guidance 451 4.60e-07 4.83e-06 0.16300 0.071100 1.46e-01 9.71e-03 9.82e-08
Cell death signalling via NRAGE, NRIF and NADE 69 7.34e-02 1.30e-01 0.16200 0.056900 1.52e-01 4.14e-01 2.88e-02
Mitotic Anaphase 223 5.90e-04 2.32e-03 0.16200 0.067200 1.47e-01 8.36e-02 1.56e-04
Downstream signaling of activated FGFR1 20 4.93e-01 5.94e-01 0.16000 0.148000 5.94e-02 2.51e-01 6.45e-01
L13a-mediated translational silencing of Ceruloplasmin expression 109 2.28e-02 4.89e-02 0.16000 -0.060700 -1.48e-01 2.74e-01 7.77e-03
Other interleukin signaling 18 2.70e-01 3.68e-01 0.15900 -0.024800 1.57e-01 8.56e-01 2.47e-01
Diseases associated with glycosaminoglycan metabolism 25 1.47e-01 2.29e-01 0.15800 -0.035200 1.54e-01 7.60e-01 1.82e-01
Regulation of KIT signaling 15 4.74e-01 5.75e-01 0.15800 0.022400 1.56e-01 8.80e-01 2.94e-01
FRS-mediated FGFR2 signaling 14 3.20e-01 4.23e-01 0.15800 0.150000 -4.80e-02 3.31e-01 7.56e-01
RUNX2 regulates osteoblast differentiation 17 2.49e-01 3.45e-01 0.15700 -0.149000 5.07e-02 2.89e-01 7.18e-01
Phase I - Functionalization of compounds 61 2.44e-01 3.40e-01 0.15700 0.104000 1.18e-01 1.61e-01 1.11e-01
Synthesis of IP3 and IP4 in the cytosol 22 1.83e-01 2.72e-01 0.15600 -0.040900 1.51e-01 7.40e-01 2.20e-01
SUMOylation of RNA binding proteins 47 1.15e-01 1.88e-01 0.15600 -0.028000 -1.54e-01 7.40e-01 6.82e-02
Mitotic Metaphase and Anaphase 224 9.38e-04 3.51e-03 0.15600 0.064700 1.42e-01 9.52e-02 2.52e-04
Non-integrin membrane-ECM interactions 37 4.20e-01 5.21e-01 0.15500 0.123000 9.54e-02 1.97e-01 3.16e-01
Nervous system development 470 4.39e-07 4.68e-06 0.15500 0.062500 1.42e-01 2.02e-02 1.28e-07
Transcriptional regulation of pluripotent stem cells 20 5.88e-01 6.76e-01 0.15500 0.079700 1.33e-01 5.37e-01 3.03e-01
Transcriptional regulation by small RNAs 63 2.44e-01 3.40e-01 0.15500 0.104000 1.15e-01 1.55e-01 1.14e-01
mRNA Capping 29 4.27e-01 5.29e-01 0.15500 0.069100 1.38e-01 5.19e-01 1.97e-01
Switching of origins to a post-replicative state 89 8.78e-02 1.52e-01 0.15500 0.075400 1.35e-01 2.19e-01 2.78e-02
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 3.87e-01 4.92e-01 0.15400 -0.136000 7.20e-02 4.35e-01 6.79e-01
Sema3A PAK dependent Axon repulsion 16 6.69e-01 7.47e-01 0.15400 0.130000 8.28e-02 3.70e-01 5.66e-01
Interleukin receptor SHC signaling 23 4.67e-01 5.70e-01 0.15300 0.055100 1.43e-01 6.47e-01 2.36e-01
Transcriptional activation of mitochondrial biogenesis 51 3.02e-01 4.04e-01 0.15300 0.088700 1.24e-01 2.73e-01 1.25e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 9.29e-02 1.59e-01 0.15200 0.009570 1.52e-01 9.11e-01 7.42e-02
Signaling by the B Cell Receptor (BCR) 161 2.47e-03 7.72e-03 0.15200 0.146000 4.21e-02 1.38e-03 3.57e-01
Cytokine Signaling in Immune system 733 2.08e-08 2.95e-07 0.15200 0.079500 1.29e-01 2.46e-04 2.71e-09
Lysine catabolism 11 5.26e-01 6.22e-01 0.15100 -0.007730 1.51e-01 9.65e-01 3.86e-01
Nonhomologous End-Joining (NHEJ) 42 3.79e-01 4.85e-01 0.15100 0.086800 1.23e-01 3.31e-01 1.66e-01
ISG15 antiviral mechanism 72 1.97e-01 2.90e-01 0.15100 -0.089200 -1.22e-01 1.91e-01 7.45e-02
Molecules associated with elastic fibres 21 4.91e-01 5.92e-01 0.15000 0.047900 1.42e-01 7.04e-01 2.60e-01
Ion transport by P-type ATPases 43 2.54e-02 5.36e-02 0.14900 -0.117000 9.23e-02 1.85e-01 2.95e-01
RNA Polymerase III Transcription Initiation 36 3.85e-01 4.90e-01 0.14900 -0.132000 -6.85e-02 1.70e-01 4.77e-01
SUMOylation of ubiquitinylation proteins 39 2.12e-01 3.04e-01 0.14900 -0.031500 -1.45e-01 7.33e-01 1.16e-01
SRP-dependent cotranslational protein targeting to membrane 110 6.64e-02 1.20e-01 0.14800 -0.074000 -1.28e-01 1.80e-01 2.00e-02
Transcription of the HIV genome 67 6.53e-02 1.18e-01 0.14700 0.026400 1.45e-01 7.09e-01 4.06e-02
MicroRNA (miRNA) biogenesis 24 3.57e-01 4.63e-01 0.14700 0.021200 1.45e-01 8.57e-01 2.18e-01
Glucagon-type ligand receptors 20 4.74e-01 5.75e-01 0.14600 0.142000 3.41e-02 2.70e-01 7.92e-01
Host Interactions of HIV factors 129 4.25e-02 8.24e-02 0.14600 0.071200 1.28e-01 1.63e-01 1.22e-02
DNA Damage Recognition in GG-NER 38 4.29e-02 8.29e-02 0.14600 -0.104000 1.02e-01 2.65e-01 2.77e-01
Cap-dependent Translation Initiation 117 3.97e-02 7.77e-02 0.14400 -0.057100 -1.32e-01 2.86e-01 1.34e-02
Eukaryotic Translation Initiation 117 3.97e-02 7.77e-02 0.14400 -0.057100 -1.32e-01 2.86e-01 1.34e-02
DNA Double Strand Break Response 47 8.94e-02 1.54e-01 0.14300 -0.004220 1.43e-01 9.60e-01 8.89e-02
Ras activation upon Ca2+ influx through NMDA receptor 15 6.67e-01 7.46e-01 0.14300 -0.057700 -1.31e-01 6.99e-01 3.79e-01
Inositol phosphate metabolism 42 1.29e-01 2.07e-01 0.14300 0.001240 1.43e-01 9.89e-01 1.09e-01
Signaling by Activin 10 5.59e-01 6.50e-01 0.14300 0.021400 -1.41e-01 9.07e-01 4.39e-01
Association of TriC/CCT with target proteins during biosynthesis 37 1.45e-01 2.27e-01 0.14300 -0.006980 1.43e-01 9.41e-01 1.33e-01
TP53 Regulates Transcription of DNA Repair Genes 61 2.11e-02 4.58e-02 0.14300 -0.139000 3.44e-02 6.11e-02 6.43e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 1.75e-01 2.64e-01 0.14300 -0.095100 1.06e-01 4.40e-01 3.87e-01
Caspase-mediated cleavage of cytoskeletal proteins 12 5.17e-01 6.15e-01 0.14200 -0.014700 1.41e-01 9.30e-01 3.96e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 5.27e-01 6.23e-01 0.14200 0.057200 1.30e-01 6.28e-01 2.70e-01
PECAM1 interactions 12 3.88e-01 4.92e-01 0.14200 -0.100000 1.01e-01 5.49e-01 5.44e-01
IGF1R signaling cascade 36 5.02e-01 6.01e-01 0.14200 0.109000 9.19e-02 2.60e-01 3.40e-01
RMTs methylate histone arginines 37 5.60e-02 1.04e-01 0.14200 -0.088500 1.11e-01 3.51e-01 2.42e-01
IRS-related events triggered by IGF1R 35 4.74e-01 5.75e-01 0.14200 0.119000 7.74e-02 2.22e-01 4.28e-01
SUMOylation of DNA damage response and repair proteins 77 1.34e-01 2.13e-01 0.14200 -0.058200 -1.29e-01 3.78e-01 4.97e-02
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 4.16e-01 5.18e-01 0.14100 0.024300 1.39e-01 8.40e-01 2.47e-01
Neuronal System 253 4.30e-03 1.26e-02 0.14100 0.073000 1.21e-01 4.56e-02 9.62e-04
VEGFR2 mediated vascular permeability 26 1.80e-01 2.70e-01 0.14100 -0.046300 1.33e-01 6.83e-01 2.41e-01
Olfactory Signaling Pathway 55 7.69e-02 1.36e-01 0.14100 0.141000 2.51e-03 7.11e-02 9.74e-01
Regulation of beta-cell development 19 3.70e-01 4.76e-01 0.14000 -0.013000 1.39e-01 9.22e-01 2.94e-01
Nuclear Receptor transcription pathway 37 7.37e-02 1.31e-01 0.13900 -0.122000 6.62e-02 1.98e-01 4.86e-01
Acetylcholine Neurotransmitter Release Cycle 11 8.09e-01 8.64e-01 0.13900 -0.081200 -1.13e-01 6.41e-01 5.18e-01
Nicotinamide salvaging 14 6.42e-01 7.22e-01 0.13900 -0.133000 -3.70e-02 3.87e-01 8.10e-01
Separation of Sister Chromatids 167 3.15e-02 6.41e-02 0.13800 0.071600 1.18e-01 1.10e-01 8.55e-03
E2F mediated regulation of DNA replication 22 4.04e-01 5.08e-01 0.13800 -0.010900 -1.37e-01 9.29e-01 2.65e-01
Signaling by FGFR2 60 2.79e-01 3.79e-01 0.13800 0.068900 1.19e-01 3.56e-01 1.11e-01
Phase II - Conjugation of compounds 66 3.00e-01 4.01e-01 0.13700 0.085400 1.08e-01 2.30e-01 1.30e-01
Chromatin modifying enzymes 217 1.75e-06 1.54e-05 0.13700 -0.041900 1.31e-01 2.87e-01 9.16e-04
Chromatin organization 217 1.75e-06 1.54e-05 0.13700 -0.041900 1.31e-01 2.87e-01 9.16e-04
RUNX2 regulates bone development 22 2.53e-01 3.50e-01 0.13700 -0.044500 1.30e-01 7.18e-01 2.93e-01
SHC-mediated cascade:FGFR1 12 8.05e-01 8.61e-01 0.13700 0.107000 8.51e-02 5.21e-01 6.10e-01
SUMOylation of transcription cofactors 44 1.20e-01 1.94e-01 0.13700 -0.008090 1.36e-01 9.26e-01 1.18e-01
Regulation of TP53 Activity 152 7.37e-03 1.97e-02 0.13700 -0.133000 -3.17e-02 4.70e-03 5.00e-01
Cytosolic tRNA aminoacylation 24 1.88e-01 2.78e-01 0.13700 0.071900 -1.16e-01 5.42e-01 3.25e-01
Collagen biosynthesis and modifying enzymes 46 1.68e-01 2.55e-01 0.13700 0.015100 1.36e-01 8.60e-01 1.11e-01
RNA Polymerase I Promoter Clearance 63 3.24e-01 4.26e-01 0.13600 0.085200 1.07e-01 2.42e-01 1.44e-01
RNA Polymerase I Transcription 63 3.24e-01 4.26e-01 0.13600 0.085200 1.07e-01 2.42e-01 1.44e-01
Polo-like kinase mediated events 15 4.17e-01 5.18e-01 0.13600 -0.036100 1.31e-01 8.09e-01 3.81e-01
M Phase 359 4.01e-04 1.65e-03 0.13500 0.061800 1.21e-01 4.43e-02 8.77e-05
PI-3K cascade:FGFR2 12 4.47e-01 5.49e-01 0.13500 0.066200 -1.18e-01 6.91e-01 4.80e-01
Activation of NMDA receptors and postsynaptic events 58 3.71e-01 4.77e-01 0.13500 0.089100 1.01e-01 2.40e-01 1.82e-01
Nephrin family interactions 18 5.35e-01 6.30e-01 0.13500 -0.133000 -2.26e-02 3.30e-01 8.68e-01
The phototransduction cascade 26 5.42e-01 6.34e-01 0.13400 -0.122000 -5.42e-02 2.80e-01 6.32e-01
Chondroitin sulfate/dermatan sulfate metabolism 38 2.10e-01 3.01e-01 0.13300 0.004400 1.33e-01 9.63e-01 1.55e-01
Ion homeostasis 41 6.66e-02 1.20e-01 0.13300 -0.114000 6.90e-02 2.07e-01 4.45e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 7.32e-01 8.00e-01 0.13200 0.029100 1.29e-01 8.74e-01 4.79e-01
TP53 Regulates Transcription of Cell Cycle Genes 47 2.28e-01 3.22e-01 0.13200 0.129000 2.80e-02 1.25e-01 7.40e-01
RNA Polymerase I Transcription Termination 27 2.07e-01 2.99e-01 0.13200 0.043400 -1.25e-01 6.97e-01 2.61e-01
Biological oxidations 132 1.18e-01 1.92e-01 0.13100 0.084300 1.00e-01 9.44e-02 4.67e-02
Cell-cell junction organization 38 2.47e-01 3.43e-01 0.13100 0.130000 1.14e-02 1.65e-01 9.03e-01
Translesion Synthesis by POLH 18 7.22e-01 7.91e-01 0.13100 -0.070400 -1.10e-01 6.05e-01 4.19e-01
Interleukin-2 family signaling 38 3.97e-01 5.01e-01 0.13000 0.045400 1.22e-01 6.28e-01 1.94e-01
G alpha (q) signalling events 132 3.17e-02 6.44e-02 0.13000 0.039100 1.24e-01 4.38e-01 1.41e-02
Blood group systems biosynthesis 17 7.46e-01 8.12e-01 0.13000 0.073600 1.07e-01 5.99e-01 4.46e-01
PI3K/AKT Signaling in Cancer 80 1.98e-01 2.91e-01 0.12800 0.056500 1.15e-01 3.82e-01 7.56e-02
Activation of BH3-only proteins 30 4.65e-01 5.67e-01 0.12800 0.038500 1.22e-01 7.15e-01 2.47e-01
G alpha (i) signalling events 243 1.93e-02 4.27e-02 0.12700 0.073800 1.04e-01 4.75e-02 5.28e-03
Ovarian tumor domain proteases 37 2.30e-01 3.25e-01 0.12700 -0.001650 1.27e-01 9.86e-01 1.80e-01
Mitotic G2-G2/M phases 180 1.19e-02 2.92e-02 0.12700 0.039000 1.21e-01 3.67e-01 5.23e-03
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 1.81e-01 2.72e-01 0.12600 -0.041800 -1.19e-01 5.40e-01 7.99e-02
Cellular hexose transport 15 7.13e-01 7.83e-01 0.12600 -0.045500 -1.18e-01 7.60e-01 4.30e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 7.01e-01 7.74e-01 0.12600 0.091300 8.70e-02 4.39e-01 4.61e-01
Cargo trafficking to the periciliary membrane 47 2.77e-01 3.76e-01 0.12600 0.122000 2.96e-02 1.47e-01 7.25e-01
STING mediated induction of host immune responses 15 8.01e-01 8.59e-01 0.12500 0.083100 9.40e-02 5.77e-01 5.29e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 1.29e-01 2.06e-01 0.12500 0.014400 1.25e-01 8.43e-01 8.72e-02
IRS-mediated signalling 34 5.42e-01 6.34e-01 0.12500 0.109000 6.08e-02 2.70e-01 5.39e-01
Post NMDA receptor activation events 48 4.04e-01 5.08e-01 0.12500 0.057100 1.11e-01 4.94e-01 1.82e-01
Lewis blood group biosynthesis 13 5.20e-01 6.16e-01 0.12500 -0.120000 3.54e-02 4.54e-01 8.25e-01
Downstream signaling of activated FGFR2 19 3.76e-01 4.80e-01 0.12300 0.114000 -4.48e-02 3.89e-01 7.35e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 3.03e-01 4.04e-01 0.12100 0.022000 1.19e-01 8.03e-01 1.75e-01
SLC-mediated transmembrane transport 178 5.93e-02 1.09e-01 0.12100 0.063100 1.03e-01 1.46e-01 1.74e-02
Signaling by FGFR 69 1.81e-01 2.72e-01 0.12100 0.029600 1.17e-01 6.70e-01 9.31e-02
Condensation of Prometaphase Chromosomes 11 6.02e-01 6.87e-01 0.12100 -0.031800 1.16e-01 8.55e-01 5.04e-01
CD28 co-stimulation 33 3.03e-01 4.04e-01 0.12000 -0.120000 3.64e-03 2.32e-01 9.71e-01
Peptide ligand-binding receptors 95 2.83e-01 3.83e-01 0.12000 0.086300 8.32e-02 1.46e-01 1.61e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 6.93e-01 7.65e-01 0.11900 0.006330 -1.19e-01 9.72e-01 5.14e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 6.81e-01 7.57e-01 0.11900 -0.093400 -7.41e-02 3.92e-01 4.97e-01
Interleukin-7 signaling 21 7.60e-01 8.24e-01 0.11900 0.082200 8.55e-02 5.14e-01 4.98e-01
G2/M Transition 178 1.77e-02 3.95e-02 0.11800 0.032600 1.14e-01 4.54e-01 8.75e-03
Diseases associated with N-glycosylation of proteins 17 7.58e-01 8.23e-01 0.11800 0.056500 1.04e-01 6.87e-01 4.58e-01
TRAF6 mediated IRF7 activation 15 7.45e-01 8.12e-01 0.11800 0.043100 1.10e-01 7.73e-01 4.61e-01
Late Phase of HIV Life Cycle 131 8.36e-02 1.46e-01 0.11800 0.044900 1.09e-01 3.75e-01 3.10e-02
TP53 Regulates Transcription of Death Receptors and Ligands 12 7.97e-01 8.57e-01 0.11800 0.109000 4.51e-02 5.14e-01 7.87e-01
Pregnenolone biosynthesis 10 6.44e-01 7.24e-01 0.11800 -0.031000 1.14e-01 8.65e-01 5.34e-01
Interleukin-2 signaling 11 5.64e-01 6.55e-01 0.11700 -0.064900 9.78e-02 7.09e-01 5.75e-01
SUMOylation of chromatin organization proteins 57 1.98e-01 2.90e-01 0.11700 -0.013100 -1.16e-01 8.64e-01 1.29e-01
TRAF3-dependent IRF activation pathway 13 8.48e-01 8.95e-01 0.11700 0.080200 8.48e-02 6.17e-01 5.97e-01
SUMOylation of DNA replication proteins 46 5.06e-01 6.04e-01 0.11600 -0.058800 -9.95e-02 4.90e-01 2.43e-01
mRNA Splicing - Minor Pathway 52 1.71e-01 2.59e-01 0.11500 -0.005920 1.15e-01 9.41e-01 1.51e-01
Anti-inflammatory response favouring Leishmania parasite infection 167 2.96e-04 1.28e-03 0.11500 0.099700 -5.75e-02 2.62e-02 2.00e-01
Leishmania parasite growth and survival 167 2.96e-04 1.28e-03 0.11500 0.099700 -5.75e-02 2.62e-02 2.00e-01
DAP12 signaling 28 2.51e-01 3.47e-01 0.11500 -0.060600 9.76e-02 5.79e-01 3.71e-01
Regulation of TP53 Activity through Methylation 19 7.87e-01 8.48e-01 0.11300 -0.068200 -9.03e-02 6.07e-01 4.95e-01
Deactivation of the beta-catenin transactivating complex 36 1.74e-01 2.63e-01 0.11300 -0.064900 9.25e-02 5.00e-01 3.37e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 6.29e-01 7.10e-01 0.11300 0.090200 6.81e-02 3.43e-01 4.74e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 4.55e-01 5.57e-01 0.11200 -0.029300 -1.08e-01 7.55e-01 2.50e-01
ATF4 activates genes in response to endoplasmic reticulum stress 26 3.56e-01 4.63e-01 0.11200 0.107000 -3.04e-02 3.43e-01 7.88e-01
G1/S-Specific Transcription 29 4.64e-01 5.67e-01 0.11100 -0.010100 -1.11e-01 9.25e-01 3.02e-01
Serotonin Neurotransmitter Release Cycle 14 8.16e-01 8.69e-01 0.11000 -0.097800 -5.10e-02 5.26e-01 7.41e-01
SHC-mediated cascade:FGFR2 12 6.38e-01 7.19e-01 0.11000 0.026500 -1.06e-01 8.74e-01 5.23e-01
Synthesis, secretion, and deacylation of Ghrelin 11 6.21e-01 7.03e-01 0.10800 0.053500 -9.42e-02 7.59e-01 5.89e-01
Generic Transcription Pathway 1078 4.82e-06 3.46e-05 0.10800 -0.088800 -6.19e-02 8.57e-07 6.01e-04
Fertilization 12 8.37e-01 8.87e-01 0.10800 0.097800 4.60e-02 5.58e-01 7.82e-01
ADORA2B mediated anti-inflammatory cytokines production 72 3.75e-01 4.80e-01 0.10800 0.050700 9.49e-02 4.57e-01 1.64e-01
Phosphorylation of the APC/C 20 7.67e-01 8.30e-01 0.10800 0.093800 5.27e-02 4.68e-01 6.83e-01
HCMV Early Events 74 3.66e-01 4.72e-01 0.10800 0.094800 5.07e-02 1.58e-01 4.51e-01
Regulation of TP53 Expression and Degradation 36 2.23e-01 3.17e-01 0.10700 -0.094000 5.09e-02 3.29e-01 5.97e-01
Chromosome Maintenance 105 3.28e-01 4.30e-01 0.10700 -0.071500 -7.93e-02 2.06e-01 1.60e-01
Neurexins and neuroligins 35 5.61e-01 6.52e-01 0.10600 -0.099800 -3.54e-02 3.07e-01 7.17e-01
DNA Double-Strand Break Repair 135 2.44e-01 3.40e-01 0.10500 -0.080500 -6.78e-02 1.06e-01 1.74e-01
Cytochrome P450 - arranged by substrate type 32 7.03e-01 7.75e-01 0.10400 0.060500 8.51e-02 5.53e-01 4.05e-01
FGFR2 alternative splicing 25 6.57e-01 7.37e-01 0.10400 0.031900 9.92e-02 7.83e-01 3.91e-01
Viral Messenger RNA Synthesis 44 6.43e-01 7.23e-01 0.10300 -0.068100 -7.77e-02 4.35e-01 3.72e-01
Downstream TCR signaling 100 2.04e-01 2.96e-01 0.10300 0.033400 9.76e-02 5.64e-01 9.18e-02
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 25 6.15e-01 6.98e-01 0.10300 0.020600 1.01e-01 8.58e-01 3.82e-01
Cytosolic sensors of pathogen-associated DNA 62 1.10e-01 1.82e-01 0.10300 -0.035400 9.67e-02 6.30e-01 1.88e-01
IL-6-type cytokine receptor ligand interactions 12 7.38e-01 8.05e-01 0.10300 0.103000 2.34e-04 5.38e-01 9.99e-01
Formation of the ternary complex, and subsequently, the 43S complex 51 2.48e-01 3.45e-01 0.10200 0.008230 -1.01e-01 9.19e-01 2.11e-01
Early Phase of HIV Life Cycle 14 8.44e-01 8.91e-01 0.10100 -0.047600 -8.94e-02 7.58e-01 5.63e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 4.06e-01 5.09e-01 0.10100 0.101000 7.08e-03 2.69e-01 9.38e-01
Nucleosome assembly 40 4.06e-01 5.09e-01 0.10100 0.101000 7.08e-03 2.69e-01 9.38e-01
Sulfur amino acid metabolism 22 4.47e-01 5.49e-01 0.10100 -0.046200 8.93e-02 7.07e-01 4.68e-01
PI3K Cascade 30 7.48e-01 8.14e-01 0.10000 0.078100 6.32e-02 4.59e-01 5.49e-01
HIV Life Cycle 144 1.52e-01 2.34e-01 0.10000 0.040600 9.16e-02 4.01e-01 5.78e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 8.54e-01 8.98e-01 0.10000 -0.069700 -7.18e-02 6.19e-01 6.08e-01
Constitutive Signaling by Aberrant PI3K in Cancer 53 4.44e-01 5.47e-01 0.09900 0.094400 2.96e-02 2.34e-01 7.09e-01
Formation of Incision Complex in GG-NER 43 6.37e-01 7.19e-01 0.09870 0.083600 5.24e-02 3.43e-01 5.52e-01
Synaptic adhesion-like molecules 15 5.94e-01 6.81e-01 0.09840 -0.088300 4.34e-02 5.54e-01 7.71e-01
TCR signaling 121 1.04e-01 1.75e-01 0.09820 0.015600 9.69e-02 7.67e-01 6.55e-02
PKMTs methylate histone lysines 44 3.60e-01 4.66e-01 0.09800 -0.098000 3.52e-04 2.61e-01 9.97e-01
TICAM1-dependent activation of IRF3/IRF7 12 8.84e-01 9.21e-01 0.09790 0.052400 8.27e-02 7.53e-01 6.20e-01
Cilium Assembly 180 1.17e-01 1.91e-01 0.09780 -0.042300 -8.82e-02 3.28e-01 4.12e-02
Mitochondrial protein import 64 5.68e-01 6.57e-01 0.09680 0.073700 6.28e-02 3.08e-01 3.85e-01
Regulation of TP53 Degradation 35 2.82e-01 3.82e-01 0.09650 -0.072000 6.43e-02 4.61e-01 5.10e-01
Inactivation, recovery and regulation of the phototransduction cascade 25 6.85e-01 7.60e-01 0.09650 -0.092800 -2.66e-02 4.22e-01 8.18e-01
Regulation of innate immune responses to cytosolic DNA 14 6.35e-01 7.16e-01 0.09580 -0.087000 3.99e-02 5.73e-01 7.96e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 6.80e-01 7.57e-01 0.09560 -0.093600 1.99e-02 5.44e-01 8.98e-01
Lysosphingolipid and LPA receptors 11 7.76e-01 8.38e-01 0.09560 -0.095500 3.57e-03 5.83e-01 9.84e-01
Cyclin D associated events in G1 47 6.03e-01 6.87e-01 0.09550 0.044700 8.44e-02 5.96e-01 3.17e-01
G1 Phase 47 6.03e-01 6.87e-01 0.09550 0.044700 8.44e-02 5.96e-01 3.17e-01
Adaptive Immune System 753 5.84e-05 3.03e-04 0.09470 0.031000 8.95e-02 1.48e-01 2.93e-05
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 5.65e-01 6.56e-01 0.09460 0.017400 9.30e-02 8.61e-01 3.48e-01
CDC6 association with the ORC:origin complex 11 6.86e-01 7.60e-01 0.09390 0.062700 -6.99e-02 7.19e-01 6.88e-01
DNA Damage Bypass 47 4.19e-01 5.21e-01 0.09390 -0.009840 -9.34e-02 9.07e-01 2.68e-01
Transport of Mature Transcript to Cytoplasm 81 3.97e-01 5.02e-01 0.09350 -0.038100 -8.54e-02 5.53e-01 1.84e-01
Gene expression (Transcription) 1325 3.15e-05 1.76e-04 0.09340 -0.072000 -5.95e-02 1.09e-05 2.77e-04
Regulation of TP53 Activity through Phosphorylation 88 4.89e-01 5.91e-01 0.09340 -0.062700 -6.92e-02 3.09e-01 2.62e-01
Termination of O-glycan biosynthesis 16 5.92e-01 6.79e-01 0.09270 -0.075800 5.34e-02 6.00e-01 7.11e-01
NCAM signaling for neurite out-growth 43 5.01e-01 6.01e-01 0.09260 -0.017000 -9.10e-02 8.47e-01 3.02e-01
Signaling by BMP 21 5.39e-01 6.33e-01 0.09230 0.085300 -3.52e-02 4.99e-01 7.80e-01
Signaling by Retinoic Acid 31 4.16e-01 5.18e-01 0.09170 -0.031300 8.62e-02 7.63e-01 4.06e-01
Homology Directed Repair 110 4.30e-01 5.32e-01 0.09110 -0.064600 -6.42e-02 2.42e-01 2.45e-01
GPCR downstream signalling 489 4.18e-03 1.24e-02 0.09110 0.034100 8.44e-02 1.96e-01 1.39e-03
Signaling by GPCR 534 1.93e-03 6.43e-03 0.09090 0.031300 8.53e-02 2.17e-01 7.46e-04
CLEC7A (Dectin-1) induces NFAT activation 11 7.26e-01 7.94e-01 0.09080 -0.082600 3.77e-02 6.35e-01 8.29e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 8.53e-01 8.98e-01 0.08910 0.072000 5.25e-02 5.77e-01 6.84e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 19 8.44e-01 8.91e-01 0.08880 -0.077000 -4.41e-02 5.61e-01 7.39e-01
Xenobiotics 11 8.29e-01 8.80e-01 0.08830 -0.006930 -8.80e-02 9.68e-01 6.13e-01
DNA Repair 289 5.86e-02 1.08e-01 0.08700 -0.079500 -3.51e-02 2.00e-02 3.04e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.23e-01 3.17e-01 0.08660 0.080900 -3.09e-02 2.82e-01 6.82e-01
Post-translational modification: synthesis of GPI-anchored proteins 56 4.29e-01 5.31e-01 0.08630 0.011200 8.56e-02 8.85e-01 2.68e-01
Basigin interactions 22 8.49e-01 8.95e-01 0.08590 0.049900 6.99e-02 6.85e-01 5.70e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.98e-01 8.57e-01 0.08560 -0.017900 -8.37e-02 8.98e-01 5.50e-01
Deadenylation-dependent mRNA decay 53 4.16e-01 5.18e-01 0.08560 0.085500 4.25e-03 2.82e-01 9.57e-01
G2/M Checkpoints 138 3.34e-01 4.37e-01 0.08550 0.044400 7.31e-02 3.68e-01 1.38e-01
Regulation of RUNX1 Expression and Activity 18 8.43e-01 8.91e-01 0.08530 -0.077900 -3.49e-02 5.67e-01 7.97e-01
RNA Polymerase II Transcription 1197 1.43e-04 6.59e-04 0.08470 -0.072300 -4.41e-02 2.57e-05 1.03e-02
mRNA Splicing - Major Pathway 179 1.41e-02 3.35e-02 0.08440 -0.028900 7.93e-02 5.05e-01 6.71e-02
Transcriptional Regulation by TP53 351 8.66e-03 2.27e-02 0.08400 0.013400 8.30e-02 6.67e-01 7.58e-03
Synthesis of PA 32 7.49e-01 8.14e-01 0.08350 0.076000 3.45e-02 4.57e-01 7.36e-01
Recruitment of NuMA to mitotic centrosomes 79 5.42e-01 6.34e-01 0.08310 -0.072000 -4.15e-02 2.69e-01 5.23e-01
HATs acetylate histones 93 8.61e-02 1.50e-01 0.08260 -0.053200 6.32e-02 3.75e-01 2.92e-01
DNA Replication Pre-Initiation 82 4.74e-01 5.75e-01 0.08260 0.032400 7.59e-02 6.12e-01 2.35e-01
Translation initiation complex formation 58 2.31e-01 3.25e-01 0.08250 0.070800 -4.24e-02 3.51e-01 5.76e-01
Epigenetic regulation of gene expression 100 5.25e-01 6.21e-01 0.08240 0.052400 6.35e-02 3.65e-01 2.72e-01
Centrosome maturation 80 5.17e-01 6.15e-01 0.08210 -0.073500 -3.66e-02 2.56e-01 5.72e-01
Recruitment of mitotic centrosome proteins and complexes 80 5.17e-01 6.15e-01 0.08210 -0.073500 -3.66e-02 2.56e-01 5.72e-01
Reproduction 80 6.10e-01 6.95e-01 0.08130 0.060800 5.39e-02 3.47e-01 4.04e-01
WNT ligand biogenesis and trafficking 21 8.78e-01 9.16e-01 0.08120 0.061300 5.33e-02 6.27e-01 6.72e-01
NRAGE signals death through JNK 52 3.88e-01 4.92e-01 0.08060 -0.010800 7.99e-02 8.93e-01 3.19e-01
mRNA Splicing 187 2.22e-02 4.79e-02 0.08050 -0.021200 7.77e-02 6.18e-01 6.69e-02
mRNA decay by 5' to 3' exoribonuclease 15 6.92e-01 7.65e-01 0.07990 -0.063600 4.83e-02 6.70e-01 7.46e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 7.86e-01 8.48e-01 0.07980 0.021400 7.69e-02 8.59e-01 5.23e-01
Gene Silencing by RNA 88 3.88e-01 4.92e-01 0.07930 0.077000 1.91e-02 2.12e-01 7.57e-01
Signaling by FGFR2 in disease 32 7.94e-01 8.55e-01 0.07890 0.069100 3.81e-02 4.99e-01 7.09e-01
Regulation of TNFR1 signaling 34 6.82e-01 7.58e-01 0.07860 -0.077000 -1.59e-02 4.37e-01 8.72e-01
Neurotransmitter release cycle 38 7.02e-01 7.74e-01 0.07770 0.074000 2.38e-02 4.30e-01 8.00e-01
Meiosis 68 6.86e-01 7.60e-01 0.07740 0.054200 5.53e-02 4.39e-01 4.31e-01
Base Excision Repair 58 5.42e-01 6.34e-01 0.07690 -0.075100 -1.65e-02 3.23e-01 8.28e-01
FOXO-mediated transcription of cell cycle genes 15 7.25e-01 7.94e-01 0.07670 -0.036100 6.77e-02 8.09e-01 6.50e-01
Synthesis of PIPs at the early endosome membrane 16 8.62e-01 9.04e-01 0.07660 0.022200 7.33e-02 8.78e-01 6.12e-01
Netrin-1 signaling 40 6.13e-01 6.97e-01 0.07610 0.007720 7.57e-02 9.33e-01 4.07e-01
O-linked glycosylation 81 5.42e-01 6.34e-01 0.07600 -0.069500 -3.08e-02 2.79e-01 6.32e-01
Adherens junctions interactions 18 8.40e-01 8.90e-01 0.07550 0.018800 7.31e-02 8.90e-01 5.91e-01
Ribosomal scanning and start codon recognition 58 2.84e-01 3.83e-01 0.07550 0.061400 -4.40e-02 4.19e-01 5.63e-01
Diseases of metabolism 185 6.08e-02 1.11e-01 0.07540 -0.006950 7.51e-02 8.71e-01 7.83e-02
Glutamate Neurotransmitter Release Cycle 20 6.64e-01 7.43e-01 0.07490 0.035800 -6.58e-02 7.82e-01 6.11e-01
Dopamine Neurotransmitter Release Cycle 19 8.52e-01 8.98e-01 0.07490 -0.024200 -7.08e-02 8.55e-01 5.93e-01
Cardiac conduction 86 1.77e-01 2.66e-01 0.07370 -0.063200 3.79e-02 3.11e-01 5.43e-01
Glutamate and glutamine metabolism 12 8.71e-01 9.13e-01 0.07360 -0.007330 -7.33e-02 9.65e-01 6.60e-01
G alpha (s) signalling events 137 4.91e-01 5.93e-01 0.07320 0.044800 5.78e-02 3.65e-01 2.43e-01
TNF signaling 43 5.83e-01 6.72e-01 0.07250 0.000548 7.25e-02 9.95e-01 4.11e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 8.81e-01 9.18e-01 0.07240 0.071100 1.36e-02 6.57e-01 9.32e-01
Mitochondrial Fatty Acid Beta-Oxidation 36 6.11e-01 6.95e-01 0.07170 -0.006100 7.15e-02 9.50e-01 4.58e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 7.64e-01 8.27e-01 0.07080 0.010300 7.01e-02 9.26e-01 5.28e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 12 8.15e-01 8.69e-01 0.07060 0.025700 -6.58e-02 8.78e-01 6.93e-01
Signaling by NTRK3 (TRKC) 15 9.24e-01 9.55e-01 0.07030 0.059100 3.79e-02 6.92e-01 7.99e-01
Diseases of glycosylation 106 1.72e-01 2.60e-01 0.07020 -0.065800 2.46e-02 2.42e-01 6.61e-01
Metabolism of vitamins and cofactors 156 3.28e-01 4.30e-01 0.06980 0.023300 6.58e-02 6.16e-01 1.56e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 9.01e-01 9.35e-01 0.06850 -0.062600 -2.79e-02 6.55e-01 8.42e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 8.92e-01 9.27e-01 0.06740 0.065900 1.43e-02 6.69e-01 9.26e-01
Anchoring of the basal body to the plasma membrane 96 6.10e-01 6.95e-01 0.06740 -0.033300 -5.86e-02 5.73e-01 3.21e-01
Regulation of HSF1-mediated heat shock response 79 2.79e-01 3.79e-01 0.06660 0.031500 -5.87e-02 6.28e-01 3.67e-01
Nucleotide Excision Repair 110 1.59e-01 2.43e-01 0.06660 -0.037200 5.53e-02 5.01e-01 3.17e-01
TRP channels 17 8.77e-01 9.16e-01 0.06600 -0.014700 -6.44e-02 9.16e-01 6.46e-01
Glyoxylate metabolism and glycine degradation 24 8.19e-01 8.72e-01 0.06530 0.064500 1.04e-02 5.85e-01 9.30e-01
Mitochondrial translation 97 5.81e-01 6.69e-01 0.06470 0.025200 5.95e-02 6.68e-01 3.11e-01
Nicotinate metabolism 25 6.78e-01 7.55e-01 0.06430 -0.054100 3.48e-02 6.40e-01 7.63e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 7.89e-01 8.49e-01 0.06390 0.059400 -2.34e-02 6.71e-01 8.67e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 7.11e-01 7.82e-01 0.06380 0.034500 5.37e-02 5.96e-01 4.09e-01
Visual phototransduction 59 4.11e-01 5.15e-01 0.06320 -0.034800 5.28e-02 6.44e-01 4.83e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 8.05e-01 8.61e-01 0.06260 -0.059800 1.87e-02 6.70e-01 8.94e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 8.05e-01 8.61e-01 0.06260 -0.059800 1.87e-02 6.70e-01 8.94e-01
Kinesins 39 6.28e-01 7.10e-01 0.06260 -0.061000 1.38e-02 5.09e-01 8.82e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 9.30e-01 9.59e-01 0.06210 -0.015400 -6.02e-02 9.30e-01 7.30e-01
G0 and Early G1 27 7.62e-01 8.25e-01 0.06210 0.061900 -4.16e-03 5.77e-01 9.70e-01
Nuclear Envelope Breakdown 53 6.40e-01 7.20e-01 0.06140 -0.003660 -6.13e-02 9.63e-01 4.40e-01
Transcriptional Regulation by VENTX 38 6.67e-01 7.46e-01 0.06100 -0.060300 9.35e-03 5.20e-01 9.21e-01
Telomere Maintenance 80 4.70e-01 5.72e-01 0.06000 -0.059800 4.47e-03 3.55e-01 9.45e-01
Transcription of E2F targets under negative control by DREAM complex 19 8.22e-01 8.73e-01 0.05980 0.059000 -9.69e-03 6.56e-01 9.42e-01
Protein-protein interactions at synapses 55 5.95e-01 6.81e-01 0.05900 -0.058700 6.15e-03 4.52e-01 9.37e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 14 9.44e-01 9.66e-01 0.05890 -0.027900 -5.19e-02 8.57e-01 7.37e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 7.16e-01 7.86e-01 0.05880 -0.014500 5.70e-02 8.89e-01 5.83e-01
GABA synthesis, release, reuptake and degradation 13 8.56e-01 8.99e-01 0.05850 0.023400 -5.37e-02 8.84e-01 7.38e-01
Metabolism of RNA 686 9.71e-02 1.64e-01 0.05790 -0.031900 -4.83e-02 1.54e-01 3.11e-02
FGFR2 mutant receptor activation 22 7.60e-01 8.24e-01 0.05770 -0.030600 4.89e-02 8.04e-01 6.91e-01
APC-Cdc20 mediated degradation of Nek2A 26 9.01e-01 9.35e-01 0.05720 0.051200 2.55e-02 6.52e-01 8.22e-01
Loss of Nlp from mitotic centrosomes 68 7.12e-01 7.82e-01 0.05660 -0.054000 -1.69e-02 4.41e-01 8.09e-01
Loss of proteins required for interphase microtubule organization from the centrosome 68 7.12e-01 7.82e-01 0.05660 -0.054000 -1.69e-02 4.41e-01 8.09e-01
Mitochondrial translation initiation 91 5.43e-01 6.34e-01 0.05660 0.005830 5.63e-02 9.23e-01 3.54e-01
Defective B4GALT7 causes EDS, progeroid type 11 9.44e-01 9.66e-01 0.05560 -0.014100 -5.38e-02 9.36e-01 7.57e-01
SUMOylation of DNA methylation proteins 16 8.76e-01 9.16e-01 0.05500 -0.054600 6.17e-03 7.05e-01 9.66e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 4.02e-01 5.07e-01 0.05490 -0.036300 4.12e-02 5.80e-01 5.29e-01
Voltage gated Potassium channels 24 8.27e-01 8.78e-01 0.05460 -0.004630 5.44e-02 9.69e-01 6.45e-01
AURKA Activation by TPX2 71 6.00e-01 6.86e-01 0.05450 -0.054500 3.48e-04 4.27e-01 9.96e-01
Mitochondrial translation elongation 91 5.34e-01 6.30e-01 0.05440 0.001290 5.44e-02 9.83e-01 3.70e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 8.12e-01 8.66e-01 0.05370 0.049700 -2.03e-02 6.93e-01 8.72e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 8.12e-01 8.66e-01 0.05370 0.049700 -2.03e-02 6.93e-01 8.72e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 7.53e-01 8.18e-01 0.05370 -0.034400 -4.12e-02 5.44e-01 4.68e-01
Mitotic G1 phase and G1/S transition 148 5.75e-01 6.64e-01 0.05350 0.021700 4.90e-02 6.49e-01 3.04e-01
Receptor-type tyrosine-protein phosphatases 11 9.35e-01 9.63e-01 0.05190 0.051800 2.60e-03 7.66e-01 9.88e-01
Gap-filling DNA repair synthesis and ligation in TC-NER 64 5.65e-01 6.56e-01 0.05080 -0.047000 1.94e-02 5.16e-01 7.88e-01
Mitochondrial translation termination 91 6.19e-01 7.02e-01 0.05040 0.005710 5.01e-02 9.25e-01 4.09e-01
Cell Cycle, Mitotic 500 8.35e-02 1.46e-01 0.04890 0.004740 4.87e-02 8.56e-01 6.26e-02
Processing of Capped Intronless Pre-mRNA 28 9.38e-01 9.65e-01 0.04830 0.029600 3.82e-02 7.86e-01 7.27e-01
CRMPs in Sema3A signaling 14 8.87e-01 9.23e-01 0.04760 -0.039600 2.64e-02 7.98e-01 8.64e-01
Interleukin-35 Signalling 12 9.71e-01 9.83e-01 0.04690 -0.040600 -2.35e-02 8.08e-01 8.88e-01
Activation of SMO 13 9.26e-01 9.55e-01 0.04620 -0.005640 4.58e-02 9.72e-01 7.75e-01
RHO GTPases Activate Formins 117 4.52e-01 5.55e-01 0.04590 -0.013200 4.40e-02 8.05e-01 4.11e-01
SLC transporter disorders 75 7.29e-01 7.97e-01 0.04550 0.045100 5.72e-03 4.99e-01 9.32e-01
DCC mediated attractive signaling 13 9.56e-01 9.70e-01 0.04490 0.011200 4.35e-02 9.44e-01 7.86e-01
Defective B3GAT3 causes JDSSDHD 11 9.20e-01 9.53e-01 0.04490 -0.038000 2.38e-02 8.27e-01 8.91e-01
Eicosanoid ligand-binding receptors 13 9.54e-01 9.69e-01 0.04490 -0.009710 -4.38e-02 9.52e-01 7.85e-01
PIWI-interacting RNA (piRNA) biogenesis 24 9.57e-01 9.70e-01 0.04450 0.031500 3.15e-02 7.89e-01 7.90e-01
Cellular response to heat stress 93 5.20e-01 6.16e-01 0.04440 0.019500 -3.99e-02 7.45e-01 5.06e-01
Regulation of expression of SLITs and ROBOs 158 6.16e-01 6.99e-01 0.04320 -0.041600 -1.15e-02 3.66e-01 8.04e-01
Class A/1 (Rhodopsin-like receptors) 166 6.73e-01 7.51e-01 0.04280 0.017300 3.91e-02 7.01e-01 3.84e-01
Mitotic Prometaphase 184 7.42e-01 8.09e-01 0.04200 -0.029100 -3.02e-02 4.96e-01 4.80e-01
Class B/2 (Secretin family receptors) 55 8.68e-01 9.10e-01 0.04160 0.013600 3.93e-02 8.61e-01 6.14e-01
RNA Polymerase II Transcription Termination 65 8.80e-01 9.18e-01 0.03960 0.017200 3.57e-02 8.10e-01 6.19e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 9.44e-01 9.66e-01 0.03950 -0.033900 2.02e-02 8.53e-01 9.12e-01
Defective EXT2 causes exostoses 2 10 9.44e-01 9.66e-01 0.03950 -0.033900 2.02e-02 8.53e-01 9.12e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 8.76e-01 9.16e-01 0.03940 -0.029600 -2.60e-02 6.25e-01 6.69e-01
Amplification of signal from the kinetochores 91 8.76e-01 9.16e-01 0.03940 -0.029600 -2.60e-02 6.25e-01 6.69e-01
Processing of Intronless Pre-mRNAs 19 9.24e-01 9.55e-01 0.03920 -0.004180 3.90e-02 9.75e-01 7.69e-01
Cell Cycle Checkpoints 258 6.84e-01 7.60e-01 0.03830 0.022200 3.13e-02 5.40e-01 3.87e-01
Processing of Capped Intron-Containing Pre-mRNA 238 2.85e-01 3.84e-01 0.03740 -0.021600 3.05e-02 5.65e-01 4.18e-01
Regulation of FZD by ubiquitination 15 9.26e-01 9.55e-01 0.03650 0.022200 -2.91e-02 8.82e-01 8.46e-01
SUMO E3 ligases SUMOylate target proteins 159 5.15e-01 6.15e-01 0.03640 -0.035000 9.73e-03 4.46e-01 8.32e-01
CASP8 activity is inhibited 11 9.47e-01 9.66e-01 0.03580 0.025600 -2.49e-02 8.83e-01 8.86e-01
Dimerization of procaspase-8 11 9.47e-01 9.66e-01 0.03580 0.025600 -2.49e-02 8.83e-01 8.86e-01
Regulation by c-FLIP 11 9.47e-01 9.66e-01 0.03580 0.025600 -2.49e-02 8.83e-01 8.86e-01
mRNA 3'-end processing 56 8.60e-01 9.04e-01 0.03580 0.003740 3.56e-02 9.61e-01 6.45e-01
SUMOylation 165 5.75e-01 6.64e-01 0.03550 -0.035400 3.20e-03 4.33e-01 9.44e-01
Regulation of PTEN mRNA translation 13 9.75e-01 9.86e-01 0.03520 -0.010400 -3.36e-02 9.48e-01 8.34e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 9.74e-01 9.85e-01 0.03470 0.029700 1.80e-02 8.18e-01 8.89e-01
Signaling by ROBO receptors 198 4.08e-01 5.11e-01 0.03440 -0.027000 2.13e-02 5.12e-01 6.05e-01
Global Genome Nucleotide Excision Repair (GG-NER) 84 7.23e-01 7.92e-01 0.03400 -0.032100 1.13e-02 6.11e-01 8.58e-01
RNA Polymerase III Transcription Termination 23 9.14e-01 9.48e-01 0.03360 0.031200 -1.26e-02 7.96e-01 9.16e-01
RNA Polymerase III Abortive And Retractive Initiation 41 9.52e-01 9.68e-01 0.03330 -0.028400 -1.74e-02 7.53e-01 8.47e-01
RNA Polymerase III Transcription 41 9.52e-01 9.68e-01 0.03330 -0.028400 -1.74e-02 7.53e-01 8.47e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 9.83e-01 9.89e-01 0.03240 -0.018300 -2.67e-02 8.99e-01 8.53e-01
IRF3-mediated induction of type I IFN 12 9.76e-01 9.86e-01 0.03230 -0.004800 -3.20e-02 9.77e-01 8.48e-01
Norepinephrine Neurotransmitter Release Cycle 14 9.87e-01 9.91e-01 0.03160 0.023400 2.12e-02 8.80e-01 8.91e-01
Metabolism of amino acids and derivatives 323 4.28e-01 5.30e-01 0.03070 0.030400 -4.36e-03 3.48e-01 8.93e-01
Translation 294 4.53e-01 5.55e-01 0.03070 0.005180 -3.02e-02 8.79e-01 3.73e-01
Branched-chain amino acid catabolism 21 9.33e-01 9.61e-01 0.03040 0.013200 -2.74e-02 9.17e-01 8.28e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 9.79e-01 9.88e-01 0.03040 -0.030200 -3.57e-03 8.62e-01 9.84e-01
Dual incision in TC-NER 65 7.98e-01 8.57e-01 0.03020 -0.017600 2.45e-02 8.06e-01 7.33e-01
Signaling by KIT in disease 20 9.45e-01 9.66e-01 0.02930 0.009510 -2.77e-02 9.41e-01 8.30e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 9.45e-01 9.66e-01 0.02930 0.009510 -2.77e-02 9.41e-01 8.30e-01
Regulation of PLK1 Activity at G2/M Transition 86 7.87e-01 8.48e-01 0.02870 -0.026800 1.02e-02 6.67e-01 8.70e-01
G2/M DNA damage checkpoint 67 8.21e-01 8.73e-01 0.02870 0.012600 -2.58e-02 8.59e-01 7.15e-01
GPCR ligand binding 231 8.42e-01 8.91e-01 0.02790 0.017500 2.18e-02 6.47e-01 5.69e-01
Interaction between L1 and Ankyrins 20 9.78e-01 9.87e-01 0.02780 -0.009700 -2.60e-02 9.40e-01 8.40e-01
Methylation 12 9.81e-01 9.89e-01 0.02610 -0.026000 -1.03e-03 8.76e-01 9.95e-01
TNFR1-induced NFkappaB signaling pathway 25 9.50e-01 9.68e-01 0.02530 -0.024300 6.94e-03 8.33e-01 9.52e-01
Cell Cycle 622 2.60e-01 3.58e-01 0.02430 -0.013300 2.03e-02 5.71e-01 3.87e-01
G1/S Transition 130 8.97e-01 9.32e-01 0.02380 0.007930 2.24e-02 8.76e-01 6.59e-01
Mitotic Spindle Checkpoint 108 9.51e-01 9.68e-01 0.02140 -0.012300 -1.75e-02 8.25e-01 7.53e-01
Negative regulators of DDX58/IFIH1 signaling 34 9.63e-01 9.76e-01 0.02110 -0.000391 2.11e-02 9.97e-01 8.31e-01
Organelle biogenesis and maintenance 268 8.05e-01 8.61e-01 0.02050 0.020300 3.25e-03 5.68e-01 9.27e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 9.46e-01 9.66e-01 0.01990 -0.014400 1.37e-02 8.81e-01 8.87e-01
Diseases of mitotic cell cycle 36 9.46e-01 9.66e-01 0.01990 -0.014400 1.37e-02 8.81e-01 8.87e-01
S Phase 160 9.54e-01 9.69e-01 0.01670 -0.014100 -8.96e-03 7.58e-01 8.45e-01
Nucleotide-like (purinergic) receptors 13 9.95e-01 9.95e-01 0.01540 -0.015000 -3.44e-03 9.25e-01 9.83e-01
EML4 and NUDC in mitotic spindle formation 95 9.80e-01 9.88e-01 0.01410 -0.012000 -7.33e-03 8.40e-01 9.02e-01
Metabolism of water-soluble vitamins and cofactors 110 9.23e-01 9.55e-01 0.01370 -0.009480 9.88e-03 8.64e-01 8.58e-01
Glutathione synthesis and recycling 10 9.95e-01 9.95e-01 0.01320 -0.012700 3.30e-03 9.44e-01 9.86e-01
Processing of DNA double-strand break ends 71 9.82e-01 9.89e-01 0.01260 -0.003610 -1.20e-02 9.58e-01 8.61e-01
Synthesis of DNA 118 9.84e-01 9.89e-01 0.01200 -0.007820 -9.03e-03 8.83e-01 8.65e-01
Signaling by NODAL 13 9.94e-01 9.95e-01 0.01090 0.008480 -6.81e-03 9.58e-01 9.66e-01
Collagen chain trimerization 27 9.91e-01 9.95e-01 0.01090 0.001650 -1.07e-02 9.88e-01 9.23e-01
DNA Replication 125 9.92e-01 9.95e-01 0.00514 0.005140 -4.02e-05 9.21e-01 9.99e-01
Resolution of Sister Chromatid Cohesion 104 9.99e-01 9.99e-01 0.00214 0.001830 1.10e-03 9.74e-01 9.85e-01


Detailed Gene set reports


IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)
metric value
setSize 10
pMANOVA 8.78e-07
p.adjustMANOVA 8.31e-06
s.dist 1.22
s.low.CRP 0.845
s.high.CRP 0.886
p.low.CRP 3.74e-06
p.high.CRP 1.2e-06




Top 20 genes
Gene low CRP high CRP
CD36 10064 9814
CD14 9551 9658
TLR4 9494 9617
TLR2 9930 9118
TLR6 9634 9209
TLR1 9828 8868
LY96 9529 8995
MYD88 8651 8344
BTK 7623 7870
TIRAP 262 7730

Click HERE to show all gene set members

All member genes
low CRP high CRP
BTK 7623 7870
CD14 9551 9658
CD36 10064 9814
LY96 9529 8995
MYD88 8651 8344
TIRAP 262 7730
TLR1 9828 8868
TLR2 9930 9118
TLR4 9494 9617
TLR6 9634 9209



MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)
metric value
setSize 10
pMANOVA 8.78e-07
p.adjustMANOVA 8.31e-06
s.dist 1.22
s.low.CRP 0.845
s.high.CRP 0.886
p.low.CRP 3.74e-06
p.high.CRP 1.2e-06




Top 20 genes
Gene low CRP high CRP
CD36 10064 9814
CD14 9551 9658
TLR4 9494 9617
TLR2 9930 9118
TLR6 9634 9209
TLR1 9828 8868
LY96 9529 8995
MYD88 8651 8344
BTK 7623 7870
TIRAP 262 7730

Click HERE to show all gene set members

All member genes
low CRP high CRP
BTK 7623 7870
CD14 9551 9658
CD36 10064 9814
LY96 9529 8995
MYD88 8651 8344
TIRAP 262 7730
TLR1 9828 8868
TLR2 9930 9118
TLR4 9494 9617
TLR6 9634 9209



Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand
metric value
setSize 11
pMANOVA 1.12e-05
p.adjustMANOVA 7.28e-05
s.dist 1.05
s.low.CRP 0.77
s.high.CRP 0.72
p.low.CRP 9.7e-06
p.high.CRP 3.51e-05




Top 20 genes
Gene low CRP high CRP
S100A9 10110 10116
S100A8 10041 10093
CD36 10064 9814
CD14 9551 9658
TLR4 9494 9617
TLR2 9930 9118
TLR6 9634 9209
TLR1 9828 8868
LY96 9529 8995

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD14 9551 9658
CD36 10064 9814
HMGB1 3876 -968
LY96 9529 8995
S100A1 -7792 -5913
S100A8 10041 10093
S100A9 10110 10116
TLR1 9828 8868
TLR2 9930 9118
TLR4 9494 9617
TLR6 9634 9209



alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
metric value
setSize 12
pMANOVA 7.06e-06
p.adjustMANOVA 4.81e-05
s.dist 1.02
s.low.CRP 0.656
s.high.CRP 0.781
p.low.CRP 8.39e-05
p.high.CRP 2.8e-06




Top 20 genes
Gene low CRP high CRP
ACSL1 9679 9692
ACOX1 9598 9253
HSD17B4 9821 8748
ELOVL3 9817 8219
FADS1 7716 8547
ACAA1 6662 9280
ACOT8 6370 8924
ABCD1 6353 8582
ELOVL5 6808 6251
SCP2 6933 4053
ELOVL1 2831 8404

Click HERE to show all gene set members

All member genes
low CRP high CRP
ABCD1 6353 8582
ACAA1 6662 9280
ACOT8 6370 8924
ACOX1 9598 9253
ACSL1 9679 9692
ELOVL1 2831 8404
ELOVL3 9817 8219
ELOVL5 6808 6251
FADS1 7716 8547
FADS2 -5372 3556
HSD17B4 9821 8748
SCP2 6933 4053



alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism
metric value
setSize 12
pMANOVA 7.06e-06
p.adjustMANOVA 4.81e-05
s.dist 1.02
s.low.CRP 0.656
s.high.CRP 0.781
p.low.CRP 8.39e-05
p.high.CRP 2.8e-06




Top 20 genes
Gene low CRP high CRP
ACSL1 9679 9692
ACOX1 9598 9253
HSD17B4 9821 8748
ELOVL3 9817 8219
FADS1 7716 8547
ACAA1 6662 9280
ACOT8 6370 8924
ABCD1 6353 8582
ELOVL5 6808 6251
SCP2 6933 4053
ELOVL1 2831 8404

Click HERE to show all gene set members

All member genes
low CRP high CRP
ABCD1 6353 8582
ACAA1 6662 9280
ACOT8 6370 8924
ACOX1 9598 9253
ACSL1 9679 9692
ELOVL1 2831 8404
ELOVL3 9817 8219
ELOVL5 6808 6251
FADS1 7716 8547
FADS2 -5372 3556
HSD17B4 9821 8748
SCP2 6933 4053



Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse
metric value
setSize 24
pMANOVA 7.25e-11
p.adjustMANOVA 1.67e-09
s.dist 1.02
s.low.CRP -0.679
s.high.CRP -0.759
p.low.CRP 8.22e-09
p.high.CRP 1.2e-10




Top 20 genes
Gene low CRP high CRP
HLA-DPA1 -10849 -11186
HLA-DPB1 -10870 -11007
CD247 -11271 -10327
TRBC1 -10647 -10844
ZAP70 -10889 -10373
LCK -10358 -10719
HLA-DRA -10267 -10796
HLA-DQA1 -10079 -10935
CD3D -9569 -10471
CD3G -9054 -10504
TRBV12-3 -9339 -9872
TRAC -7973 -11179
CD3E -8133 -10695
TRBV7-9 -8541 -8307
TRAV19 -7386 -9425
HLA-DQB2 -7564 -8924
TRAV8-4 -7363 -7382
TRAV29DV5 -4800 -10814
HLA-DRB1 -5355 -7118
HLA-DQB1 -3551 -6072

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD247 -11271 -10327
CD3D -9569 -10471
CD3E -8133 -10695
CD3G -9054 -10504
CD4 3147 -5743
HLA-DPA1 -10849 -11186
HLA-DPB1 -10870 -11007
HLA-DQA1 -10079 -10935
HLA-DQA2 -5389 -3691
HLA-DQB1 -3551 -6072
HLA-DQB2 -7564 -8924
HLA-DRA -10267 -10796
HLA-DRB1 -5355 -7118
HLA-DRB5 -3678 -4235
LCK -10358 -10719
PTPN22 -8401 2469
TRAC -7973 -11179
TRAV19 -7386 -9425
TRAV29DV5 -4800 -10814
TRAV8-4 -7363 -7382
TRBC1 -10647 -10844
TRBV12-3 -9339 -9872
TRBV7-9 -8541 -8307
ZAP70 -10889 -10373



Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen
metric value
setSize 11
pMANOVA 3.19e-05
p.adjustMANOVA 0.000176
s.dist 1
s.low.CRP 0.741
s.high.CRP 0.677
p.low.CRP 2.08e-05
p.high.CRP 0.000102




Top 20 genes
Gene low CRP high CRP
CYB5R1 9974 10035
CA1 10107 9363
SLC4A1 10074 8897
HBB 10013 8750
HBA1 10009 8734
CYB5R2 9250 8814
CYB5R4 9323 8621
CA4 6753 9451
AQP1 8407 7513
CA2 3967 3723

Click HERE to show all gene set members

All member genes
low CRP high CRP
AQP1 8407 7513
CA1 10107 9363
CA2 3967 3723
CA4 6753 9451
CYB5R1 9974 10035
CYB5R2 9250 8814
CYB5R4 9323 8621
CYB5RL -7036 -10449
HBA1 10009 8734
HBB 10013 8750
SLC4A1 10074 8897



O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes
metric value
setSize 11
pMANOVA 3.19e-05
p.adjustMANOVA 0.000176
s.dist 1
s.low.CRP 0.741
s.high.CRP 0.677
p.low.CRP 2.08e-05
p.high.CRP 0.000102




Top 20 genes
Gene low CRP high CRP
CYB5R1 9974 10035
CA1 10107 9363
SLC4A1 10074 8897
HBB 10013 8750
HBA1 10009 8734
CYB5R2 9250 8814
CYB5R4 9323 8621
CA4 6753 9451
AQP1 8407 7513
CA2 3967 3723

Click HERE to show all gene set members

All member genes
low CRP high CRP
AQP1 8407 7513
CA1 10107 9363
CA2 3967 3723
CA4 6753 9451
CYB5R1 9974 10035
CYB5R2 9250 8814
CYB5R4 9323 8621
CYB5RL -7036 -10449
HBA1 10009 8734
HBB 10013 8750
SLC4A1 10074 8897



Hyaluronan uptake and degradation

Hyaluronan uptake and degradation
metric value
setSize 12
pMANOVA 3.64e-05
p.adjustMANOVA 0.000195
s.dist 0.941
s.low.CRP 0.591
s.high.CRP 0.732
p.low.CRP 0.000393
p.high.CRP 1.12e-05




Top 20 genes
Gene low CRP high CRP
CHP1 9390 10098
HEXB 9386 9202
LYVE1 8853 9498
HYAL2 8387 9968
CD44 8303 9047
STAB2 7035 5388
HYAL3 7507 4690
SLC9A1 3224 9393
GUSB 2374 9501
HMMR 1918 3372
HYAL1 888 4763
HEXA 1650 2356

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD44 8303 9047
CHP1 9390 10098
GUSB 2374 9501
HEXA 1650 2356
HEXB 9386 9202
HMMR 1918 3372
HYAL1 888 4763
HYAL2 8387 9968
HYAL3 7507 4690
LYVE1 8853 9498
SLC9A1 3224 9393
STAB2 7035 5388



Uptake and function of anthrax toxins

Uptake and function of anthrax toxins
metric value
setSize 10
pMANOVA 0.000157
p.adjustMANOVA 0.000716
s.dist 0.915
s.low.CRP 0.505
s.high.CRP 0.763
p.low.CRP 0.00568
p.high.CRP 2.93e-05




Top 20 genes
Gene low CRP high CRP
MAP2K1 9163 9879
MAP2K6 9435 9577
MAP2K3 8978 9308
FURIN 8111 10053
ANTXR2 7254 7992
PDCD6IP 7627 7201
MAP2K4 6895 7431
MAP2K2 185 8452

Click HERE to show all gene set members

All member genes
low CRP high CRP
ANTXR2 7254 7992
CALM1 -6645 1321
FURIN 8111 10053
MAP2K1 9163 9879
MAP2K2 185 8452
MAP2K3 8978 9308
MAP2K4 6895 7431
MAP2K6 9435 9577
MAP2K7 -2754 4813
PDCD6IP 7627 7201



p130Cas linkage to MAPK signaling for integrins

p130Cas linkage to MAPK signaling for integrins
metric value
setSize 11
pMANOVA 0.000221
p.adjustMANOVA 0.000981
s.dist 0.908
s.low.CRP 0.649
s.high.CRP 0.635
p.low.CRP 0.000194
p.high.CRP 0.000266




Top 20 genes
Gene low CRP high CRP
ITGA2B 9720 9409
CRK 9657 9429
APBB1IP 9427 9201
ITGB3 9450 8690
TLN1 7865 9661
FN1 10003 6211
RAP1A 8688 6973
VWF 6949 7780
PTK2 7786 3481

Click HERE to show all gene set members

All member genes
low CRP high CRP
APBB1IP 9427 9201
CRK 9657 9429
FN1 10003 6211
ITGA2B 9720 9409
ITGB3 9450 8690
PTK2 7786 3481
RAP1A 8688 6973
RAP1B -2703 4941
SRC -6857 -7229
TLN1 7865 9661
VWF 6949 7780



WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2
metric value
setSize 11
pMANOVA 0.000102
p.adjustMANOVA 0.000496
s.dist 0.841
s.low.CRP 0.395
s.high.CRP 0.742
p.low.CRP 0.0232
p.high.CRP 2.01e-05




Top 20 genes
Gene low CRP high CRP
FZD5 10104 10128
CLTC 9376 9720
CLTA 8416 8998
AP2M1 7742 9334
AP2S1 7422 8877
FZD2 6675 7410
AP2A2 3196 9217

Click HERE to show all gene set members

All member genes
low CRP high CRP
AP2A1 -3194 9104
AP2A2 3196 9217
AP2B1 -9145 2444
AP2M1 7742 9334
AP2S1 7422 8877
CLTA 8416 8998
CLTB -2857 8274
CLTC 9376 9720
FZD2 6675 7410
FZD5 10104 10128
ROR1 2411 -2323



Unwinding of DNA

Unwinding of DNA
metric value
setSize 12
pMANOVA 0.000441
p.adjustMANOVA 0.00181
s.dist 0.833
s.low.CRP -0.582
s.high.CRP -0.595
p.low.CRP 0.00048
p.high.CRP 0.000355




Top 20 genes
Gene low CRP high CRP
MCM3 -10811 -10521
MCM7 -10255 -10984
MCM8 -9375 -9034
GINS4 -6718 -9940
GINS3 -8278 -7992
MCM6 -7009 -8219
MCM4 -4706 -9052
MCM2 -5922 -5744
MCM5 -9731 -1534
GINS2 -2728 -5004
GINS1 -6319 -1858

Click HERE to show all gene set members

All member genes
low CRP high CRP
CDC45 213 -3252
GINS1 -6319 -1858
GINS2 -2728 -5004
GINS3 -8278 -7992
GINS4 -6718 -9940
MCM2 -5922 -5744
MCM3 -10811 -10521
MCM4 -4706 -9052
MCM5 -9731 -1534
MCM6 -7009 -8219
MCM7 -10255 -10984
MCM8 -9375 -9034



GRB2:SOS provides linkage to MAPK signaling for Integrins

GRB2:SOS provides linkage to MAPK signaling for Integrins
metric value
setSize 12
pMANOVA 0.000456
p.adjustMANOVA 0.00184
s.dist 0.823
s.low.CRP 0.627
s.high.CRP 0.533
p.low.CRP 0.000171
p.high.CRP 0.00139




Top 20 genes
Gene low CRP high CRP
GRB2 9631 9985
ITGA2B 9720 9409
APBB1IP 9427 9201
ITGB3 9450 8690
TLN1 7865 9661
FN1 10003 6211
RAP1A 8688 6973
VWF 6949 7780
PTK2 7786 3481

Click HERE to show all gene set members

All member genes
low CRP high CRP
APBB1IP 9427 9201
FN1 10003 6211
GRB2 9631 9985
ITGA2B 9720 9409
ITGB3 9450 8690
PTK2 7786 3481
RAP1A 8688 6973
RAP1B -2703 4941
SOS1 3534 -7412
SRC -6857 -7229
TLN1 7865 9661
VWF 6949 7780



RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate WASPs and WAVEs
metric value
setSize 35
pMANOVA 1.35e-10
p.adjustMANOVA 3.02e-09
s.dist 0.817
s.low.CRP 0.502
s.high.CRP 0.645
p.low.CRP 2.79e-07
p.high.CRP 4.06e-11




Top 20 genes
Gene low CRP high CRP
WASF1 10091 10132
CYFIP1 9724 9912
GRB2 9631 9985
ARPC1B 9259 10026
ACTB 9310 9714
RAC1 9052 9614
MAPK3 8931 9626
ARPC5 9301 9174
ARPC1A 8875 9605
WAS 8258 9323
ARPC3 8430 8946
ACTG1 7674 9499
WASF2 7535 9576
ACTR2 8743 7962
ACTR3 8622 7832
CDC42 8498 7640
BTK 7623 7870
WASF3 8142 7240
NCKAP1 6871 8168
ABI1 6692 7709

Click HERE to show all gene set members

All member genes
low CRP high CRP
ABI1 6692 7709
ABI2 -7512 -9823
ABL1 -6354 4467
ACTB 9310 9714
ACTG1 7674 9499
ACTR2 8743 7962
ACTR3 8622 7832
ARPC1A 8875 9605
ARPC1B 9259 10026
ARPC2 5327 8212
ARPC3 8430 8946
ARPC4 4637 8915
ARPC5 9301 9174
BAIAP2 2620 -682
BRK1 5522 8298
BTK 7623 7870
CDC42 8498 7640
CYFIP1 9724 9912
CYFIP2 -10558 -4935
GRB2 9631 9985
MAPK1 1052 9260
MAPK3 8931 9626
NCK1 -9250 -9113
NCKAP1 6871 8168
NCKAP1L 3966 9566
NCKIPSD 957 1858
PTK2 7786 3481
RAC1 9052 9614
WAS 8258 9323
WASF1 10091 10132
WASF2 7535 9576
WASF3 8142 7240
WASL 899 1391
WIPF1 -5700 3866
WIPF2 2722 7125



RNA Polymerase I Promoter Opening

RNA Polymerase I Promoter Opening
metric value
setSize 19
pMANOVA 4.75e-06
p.adjustMANOVA 3.44e-05
s.dist 0.814
s.low.CRP 0.499
s.high.CRP 0.643
p.low.CRP 0.000163
p.high.CRP 1.24e-06




Top 20 genes
Gene low CRP high CRP
H2BC21 9852.0 9656.0
H2AJ 8999.0 10117.0
H2BC12 9066.0 9812.0
MAPK3 8931.0 9626.0
H3-3A 9297.0 9034.0
H2AC6 8700.0 8169.0
H2BC11 8424.0 8288.0
H2BC5 7596.0 8773.0
H2BC17 7882.0 7312.0
H2BC4 7156.0 7805.0
MBD2 7283.0 6830.0
H3C15 5262.5 7402.5
H2BC9 7965.0 4715.0
H2BC15 3036.0 6455.0
H2AZ1 1779.0 7321.0

Click HERE to show all gene set members

All member genes
low CRP high CRP
H2AC20 -790.0 6112.0
H2AC6 8700.0 8169.0
H2AJ 8999.0 10117.0
H2AZ1 1779.0 7321.0
H2AZ2 -4042.0 2210.0
H2BC11 8424.0 8288.0
H2BC12 9066.0 9812.0
H2BC15 3036.0 6455.0
H2BC17 7882.0 7312.0
H2BC21 9852.0 9656.0
H2BC4 7156.0 7805.0
H2BC5 7596.0 8773.0
H2BC9 7965.0 4715.0
H2BU1 -6349.0 -3895.0
H3-3A 9297.0 9034.0
H3C15 5262.5 7402.5
MAPK3 8931.0 9626.0
MBD2 7283.0 6830.0
UBTF -9548.0 -5841.0



Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling
metric value
setSize 12
pMANOVA 0.000224
p.adjustMANOVA 0.000988
s.dist 0.809
s.low.CRP 0.432
s.high.CRP 0.683
p.low.CRP 0.00949
p.high.CRP 4.15e-05




Top 20 genes
Gene low CRP high CRP
S100A12 10088 10121
APP 9951 9504
MAPK3 8931 9626
LGALS3 9602 8710
CAPZA2 9698 8474
CAPZA1 8666 8511
MAPK1 1052 9260
DDOST 459 8249

Click HERE to show all gene set members

All member genes
low CRP high CRP
AGER -1839 3181
APP 9951 9504
CAPZA1 8666 8511
CAPZA2 9698 8474
DDOST 459 8249
HMGB1 3876 -968
LGALS3 9602 8710
MAPK1 1052 9260
MAPK3 8931 9626
PRKCSH -3697 7582
S100A12 10088 10121
S100B -8212 -1271



PD-1 signaling

PD-1 signaling
metric value
setSize 28
pMANOVA 3.99e-08
p.adjustMANOVA 5.28e-07
s.dist 0.805
s.low.CRP -0.535
s.high.CRP -0.602
p.low.CRP 9.47e-07
p.high.CRP 3.51e-08




Top 20 genes
Gene low CRP high CRP
HLA-DPA1 -10849 -11186
HLA-DPB1 -10870 -11007
CD247 -11271 -10327
TRBC1 -10647 -10844
LCK -10358 -10719
HLA-DRA -10267 -10796
HLA-DQA1 -10079 -10935
CD3D -9569 -10471
CD3G -9054 -10504
TRBV12-3 -9339 -9872
TRAC -7973 -11179
CD3E -8133 -10695
TRBV7-9 -8541 -8307
TRAV19 -7386 -9425
HLA-DQB2 -7564 -8924
TRAV8-4 -7363 -7382
TRAV29DV5 -4800 -10814
HLA-DRB1 -5355 -7118
PDCD1 -7403 -5037
HLA-DQB1 -3551 -6072

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD247 -11271 -10327
CD274 -426 -8571
CD3D -9569 -10471
CD3E -8133 -10695
CD3G -9054 -10504
CD4 3147 -5743
CSK -5436 7707
HLA-DPA1 -10849 -11186
HLA-DPB1 -10870 -11007
HLA-DQA1 -10079 -10935
HLA-DQA2 -5389 -3691
HLA-DQB1 -3551 -6072
HLA-DQB2 -7564 -8924
HLA-DRA -10267 -10796
HLA-DRB1 -5355 -7118
HLA-DRB5 -3678 -4235
LCK -10358 -10719
PDCD1 -7403 -5037
PDCD1LG2 1843 -4094
PTPN11 4691 6614
PTPN6 -691 7862
TRAC -7973 -11179
TRAV19 -7386 -9425
TRAV29DV5 -4800 -10814
TRAV8-4 -7363 -7382
TRBC1 -10647 -10844
TRBV12-3 -9339 -9872
TRBV7-9 -8541 -8307



ROS and RNS production in phagocytes

ROS and RNS production in phagocytes
metric value
setSize 31
pMANOVA 1.32e-08
p.adjustMANOVA 1.96e-07
s.dist 0.793
s.low.CRP 0.577
s.high.CRP 0.545
p.low.CRP 2.73e-08
p.high.CRP 1.53e-07




Top 20 genes
Gene low CRP high CRP
ATP6V0A1 9995 10010
ATP6V1A 9857 9880
NCF4 9697 9856
NCF2 9748 9694
ATP6V0D1 9444 9942
ATP6V1D 9600 9482
ATP6V0C 9348 9734
SLC11A1 9129 9947
ATP6V1B2 9738 9281
CYBB 9900 8910
ATP6V1C1 9888 8528
ATP6V0B 8163 9396
ATP6V0E1 8171 9289
ATP6V1H 7942 8571
ATP6V1E1 8095 8397
NCF1 8576 7083
LPO 8757 5426
MPO 9985 4616
ATP6V1E2 8322 4968
HVCN1 7539 4235

Click HERE to show all gene set members

All member genes
low CRP high CRP
ATP6V0A1 9995 10010
ATP6V0A2 -10623 -10379
ATP6V0B 8163 9396
ATP6V0C 9348 9734
ATP6V0D1 9444 9942
ATP6V0E1 8171 9289
ATP6V0E2 -8802 -11036
ATP6V1A 9857 9880
ATP6V1B2 9738 9281
ATP6V1C1 9888 8528
ATP6V1C2 2655 -3376
ATP6V1D 9600 9482
ATP6V1E1 8095 8397
ATP6V1E2 8322 4968
ATP6V1F 3461 6917
ATP6V1G1 5204 4277
ATP6V1G2 -4714 -10140
ATP6V1H 7942 8571
CYBA -48 8901
CYBB 9900 8910
HVCN1 7539 4235
LPO 8757 5426
MPO 9985 4616
NCF1 8576 7083
NCF2 9748 9694
NCF4 9697 9856
NOS1 4727 -183
NOS3 5934 -5046
RAC2 -7677 6828
SLC11A1 9129 9947
TCIRG1 1085 9058



Signaling by Leptin

Signaling by Leptin
metric value
setSize 10
pMANOVA 0.00294
p.adjustMANOVA 0.00909
s.dist 0.789
s.low.CRP 0.587
s.high.CRP 0.527
p.low.CRP 0.00131
p.high.CRP 0.00391




Top 20 genes
Gene low CRP high CRP
SOCS3 9830 10110
IRS2 8141 9618
STAT3 8512 8606
STAT5A 6437 7973
LEPR 7286 6904
STAT5B 4758 7433
PTPN11 4691 6614
JAK2 7618 374
IRS1 6140 8

Click HERE to show all gene set members

All member genes
low CRP high CRP
IRS1 6140 8
IRS2 8141 9618
JAK2 7618 374
LEPR 7286 6904
PTPN11 4691 6614
SH2B1 -6398 -6874
SOCS3 9830 10110
STAT3 8512 8606
STAT5A 6437 7973
STAT5B 4758 7433



Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains
metric value
setSize 27
pMANOVA 2.11e-07
p.adjustMANOVA 2.39e-06
s.dist 0.783
s.low.CRP -0.564
s.high.CRP -0.542
p.low.CRP 3.81e-07
p.high.CRP 1.07e-06




Top 20 genes
Gene low CRP high CRP
HLA-DPA1 -10849 -11186
HLA-DPB1 -10870 -11007
CD247 -11271 -10327
TRBC1 -10647 -10844
LCK -10358 -10719
HLA-DRA -10267 -10796
HLA-DQA1 -10079 -10935
CD3D -9569 -10471
CD3G -9054 -10504
TRBV12-3 -9339 -9872
TRAC -7973 -11179
CD3E -8133 -10695
TRBV7-9 -8541 -8307
TRAV19 -7386 -9425
HLA-DQB2 -7564 -8924
TRAV8-4 -7363 -7382
TRAV29DV5 -4800 -10814
HLA-DRB1 -5355 -7118
HLA-DQB1 -3551 -6072
HLA-DQA2 -5389 -3691

Click HERE to show all gene set members

All member genes
low CRP high CRP
CD247 -11271 -10327
CD3D -9569 -10471
CD3E -8133 -10695
CD3G -9054 -10504
CD4 3147 -5743
CSK -5436 7707
HLA-DPA1 -10849 -11186
HLA-DPB1 -10870 -11007
HLA-DQA1 -10079 -10935
HLA-DQA2 -5389 -3691
HLA-DQB1 -3551 -6072
HLA-DQB2 -7564 -8924
HLA-DRA -10267 -10796
HLA-DRB1 -5355 -7118
HLA-DRB5 -3678 -4235
LCK -10358 -10719
PAG1 2942 5215
PTPN22 -8401 2469
PTPRC -3326 4087
PTPRJ 4613 9148
TRAC -7973 -11179
TRAV19 -7386 -9425
TRAV29DV5 -4800 -10814
TRAV8-4 -7363 -7382
TRBC1 -10647 -10844
TRBV12-3 -9339 -9872
TRBV7-9 -8541 -8307



Neutrophil degranulation

Neutrophil degranulation
metric value
setSize 456
pMANOVA 1.26e-111
p.adjustMANOVA 1.72e-108
s.dist 0.77
s.low.CRP 0.491
s.high.CRP 0.593
p.low.CRP 9.83e-73
p.high.CRP 2.07e-105




Top 20 genes
Gene low CRP high CRP
S100A9 10110 10116
SIRPA 10106 10119
IDH1 10122 10092
CTSA 10083 10131
MCEMP1 10086 10124
S100A12 10088 10121
RNASE2 10073 10107
CR1 10079 10078
CD93 10035 10122
S100A8 10041 10093
CREG1 10046 10059
MGST1 10098 9993
BST1 10108 9972
TIMP2 9988 10081
SERPINB1 10061 9986
ATP6V0A1 9995 10010
PYGL 10071 9926
PGAM1 9980 9987
GCA 10102 9849
HP 9925 10000

Click HERE to show all gene set members

All member genes
low CRP high CRP
A1BG 5929 5909
ABCA13 9410 -170
ACAA1 6662 9280
ACLY -3163 7024
ACTR10 8589 7569
ACTR1B -10279 -5884
ACTR2 8743 7962
ADAM10 9314 9481
ADAM8 -5458 6863
ADGRE3 -5376 2276
ADGRE5 -10651 4158
ADGRG3 3363 8936
AGA -7643 -940
AGL -3370 -1431
AGPAT2 9161 10022
ALAD 8384 9011
ALDH3B1 8834 9423
ALDOA 9625 9857
ALDOC -3 -2424
ALOX5 9516 9496
AMPD3 9213 9215
ANO6 9199 8127
ANPEP 9881 9819
ANXA2 8647 9102
AOC1 6446 7328
AP1M1 -3219 8558
AP2A2 3196 9217
APAF1 9873 9119
APEH -8617 5030
APRT -2805 -663
ARG1 9021 8594
ARHGAP9 -1609 8482
ARL8A 6964 9003
ARMC8 8306 5850
ARPC5 9301 9174
ARSA -218 5556
ARSB 8124 8067
ASAH1 9274 8880
ATAD3B -7970 -8653
ATG7 9062 8455
ATP11A 8506 9066
ATP11B 1885 6335
ATP6AP2 9221 7743
ATP6V0A1 9995 10010
ATP6V0C 9348 9734
ATP6V1D 9600 9482
ATP8A1 -9269 -10981
ATP8B4 7888 7537
AZU1 9483 1924
B2M -4257 -4660
B4GALT1 -4177 7099
BIN2 -7555 7878
BPI 9613 4607
BRI3 9055 9716
BST1 10108 9972
BST2 -8159 -3534
C3 -11179 -10489
C3AR1 8924 8181
C5AR1 9359 9709
C6orf120 5882 7163
CAB39 9181 8435
CAMP 9421 -389
CAND1 3497 -7234
CANT1 7020 8333
CAP1 8192 8530
CAPN1 7094 9770
CAT 9793 9327
CCT2 1978 -8922
CCT8 8723 5878
CD14 9551 9658
CD177 9810 2861
CD300A -10110 3601
CD33 9714 7077
CD36 10064 9814
CD44 8303 9047
CD47 -9758 -11025
CD53 5300 8871
CD55 9326 9842
CD58 6098 7272
CD59 4075 5772
CD63 8797 10079
CD68 8809 9128
CD93 10035 10122
CDA 9766 9792
CDK13 -9826 -1367
CEACAM1 8749 7909
CEACAM3 4583 7056
CEACAM6 8933 1336
CEACAM8 9111 1929
CEP290 2753 -10189
CFD 2998 2390
CFP 6744 8615
CHI3L1 4876 -2511
CHIT1 8764 5022
CKAP4 10101 9674
CLEC12A 6739 3764
CLEC4C -11151 -7325
CLEC4D 10004 9296
CLEC5A 9544 8477
CMTM6 8818 8010
CNN2 2919 7385
COMMD3 1068 -670
COMMD9 8869 7706
COPB1 8213 7283
COTL1 7691 8602
CPNE1 -7895 1521
CPNE3 7732 5446
CPPED1 9258 8367
CR1 10079 10078
CRACR2A -10740 -2401
CREG1 10046 10059
CRISP3 9520 5095
CRISPLD2 9508 9755
CSNK2B 1222 5287
CST3 1960 3081
CSTB 4302 7960
CTSA 10083 10131
CTSB 9526 10083
CTSC -7528 5285
CTSD 9620 10120
CTSG 9156 1689
CTSH 6991 6545
CTSS 9854 7280
CTSZ 8972 9860
CXCL1 4484 5698
CXCR1 2112 7643
CXCR2 4038 6148
CYB5R3 8185 9788
CYBA -48 8901
CYBB 9900 8910
CYFIP1 9724 9912
CYSTM1 9061 9479
DBNL 5107 8904
DDOST 459 8249
DDX3X 8543 6111
DEFA1 9407 3685
DEFA4 9471 3488
DEGS1 6718 6254
DERA 9044 8799
DGAT1 3473 6135
DIAPH1 -9216 4270
DNAJC13 9339 8451
DNAJC3 9077 8882
DNAJC5 8400 9628
DNASE1L1 7462 9707
DOCK2 6433 8942
DOK3 9913 9988
DPP7 -4737 -1700
DSC1 2498 -9997
DSN1 -8825 -8996
DSP -2099 -1252
DYNC1H1 -8881 -2533
DYNC1LI1 7894 6997
DYNLL1 6026 6499
DYNLT1 1870 5508
EEF1A1 53 -4688
EEF2 -2498 2707
ELANE 9880 4888
ENPP4 -10919 -4181
EPX 4309 -6896
ERP44 8740 6170
FABP5 4135 6969
FAF2 2326 6842
FCAR 9865 9508
FCER1G 6595 9147
FCGR2A 9414 9249
FCGR3B 4203 4625
FCN1 9889 9103
FGL2 8307 -4026
FGR 6254 9666
FOLR3 7933 7989
FPR1 9606 9929
FPR2 9572 9728
FRK 23 486
FRMPD3 -11030 -7462
FTH1 3543 5337
FTL 8704 9324
FUCA1 8013 8533
FUCA2 9577 7885
GAA 8448 8356
GALNS 6719 8385
GCA 10102 9849
GDI2 8206 7892
GGH 5742 6109
GHDC 4753 4443
GLA 8923 9083
GLB1 9091 9091
GLIPR1 9841 6015
GM2A 9396 9808
GMFG 7620 8986
GNS 9627 10060
GOLGA7 4113 4351
GPI 3712 6865
GPR84 9267 9312
GRN 9760 9908
GSDMD -1632 4125
GSN 9281 9397
GSTP1 -3317 2661
GUSB 2374 9501
GYG1 9474 9547
HBB 10013 8750
HEBP2 8767 8822
HEXB 9386 9202
HGSNAT 4689 2250
HK3 9953 9940
HLA-A -5067 570
HLA-B -1559 1570
HLA-C -2829 2125
HLA-H -8161 452
HMGB1 3876 -968
HMOX2 -10770 -8356
HP 9925 10000
HPSE 9514 8535
HRNR -7455 -5209
HSP90AA1 5309 410
HSP90AB1 2247 -6319
HSPA1A 8217 8368
HSPA1B 5673 7177
HSPA6 2686 7632
HSPA8 -8286 -8908
HUWE1 -8883 -3494
HVCN1 7539 4235
IDH1 10122 10092
IGF2R -1133 9240
ILF2 -2090 951
IMPDH1 9819 9891
IMPDH2 -3563 -10154
IQGAP1 7310 9366
IQGAP2 6198 7948
IST1 260 7296
ITGAL -10958 -4334
ITGAM 9846 10065
ITGAV 7467 6188
ITGAX 3250 8762
ITGB2 8042 10007
JUP -4305 -4960
KCMF1 7123 8439
KCNAB2 -9549 5424
KPNB1 -1223 3575
KRT1 6823 4687
LAIR1 -466 8850
LAMP1 1737 9127
LAMP2 9608 8999
LAMTOR1 9915 9919
LAMTOR2 3802 9208
LAMTOR3 9012 7104
LCN2 9447 6200
LGALS3 9602 8710
LILRB2 6423 9453
LILRB3 8958 9554
LPCAT1 -10952 2487
LRG1 6784 9458
LRRC7 -623 -1369
LTA4H 9933 9541
LTF 9374 3485
LYZ 9774 5791
MAGT1 574 3711
MAN2B1 7665 7139
MANBA 9330 6620
MAPK1 1052 9260
MAPK14 9907 9606
MCEMP1 10086 10124
METTL7A 8352 6827
MGAM 8661 9588
MGST1 10098 9993
MIF -4739 -1332
MLEC 1226 3680
MME -1752 1424
MMP25 6740 9386
MMP8 9818 1522
MMP9 9225 9700
MNDA 10027 9394
MOSPD2 9799 8045
MPO 9985 4616
MS4A3 8707 -2464
MVP 4779 8093
NAPRT 6522 8450
NBEAL2 2363 8445
NCKAP1L 3966 9566
NCSTN 9503 9869
NDUFC2 1951 7994
NEU1 9336 9571
NFAM1 9370 9863
NFKB1 7857 6377
NHLRC3 4253 1252
NIT2 -7855 -11064
NME2 2395 3054
NPC2 6632 5511
NRAS 7321 4878
OLFM4 9728 7424
OLR1 8411 -2056
ORM1 8665 8363
ORM2 -4938 149
ORMDL3 -9307 -7231
OSCAR 9651 9561
OSTF1 6441 8058
P2RX1 7223 9888
PA2G4 -997 -1395
PADI2 9767 9703
PAFAH1B2 7693 7761
PDAP1 -4620 8599
PDXK 9135 9342
PECAM1 8136 8308
PFKL -4964 514
PGAM1 9980 9987
PGLYRP1 8816 7750
PGM1 -2421 7047
PGM2 9878 9866
PGRMC1 9328 7693
PIGR 1807 -551
PKM 9904 9954
PLAC8 6624 9383
PLAU 1698 5458
PLAUR 8428 9009
PLD1 9826 9945
PLEKHO2 6392 9014
PNP 9167 8393
PPBP 7528 6376
PPIA -7248 -2108
PPIE -5515 -9064
PRCP 8403 8843
PRDX4 1893 563
PRDX6 9609 8969
PRKCD 9393 9642
PRTN3 9645 4535
PSAP 7519 7770
PSEN1 7889 8878
PSMA2 5830 5666
PSMA5 -2119 -3983
PSMB1 3915 4224
PSMB7 8034 9051
PSMC2 -2524 4517
PSMC3 -4971 4984
PSMD1 7679 7587
PSMD11 6914 6824
PSMD12 9011 5710
PSMD13 3157 7205
PSMD14 2891 3041
PSMD2 4352 8396
PSMD3 -2243 6367
PSMD6 8841 8304
PSMD7 6534 6147
PTAFR 9791 9983
PTGES2 -6197 -3780
PTPN6 -691 7862
PTPRB -9635 -4262
PTPRC -3326 4087
PTPRJ 4613 9148
PTPRN2 3436 5350
PTX3 8865 4044
PYCARD 8329 9425
PYGB -5192 3500
PYGL 10071 9926
QPCT 9809 9852
QSOX1 9451 10048
RAB10 9303 9477
RAB14 8215 7014
RAB18 9425 7287
RAB24 2905 6201
RAB27A 9164 8675
RAB31 9956 9895
RAB37 -11095 -6455
RAB3A 7816 8757
RAB3D 9596 9946
RAB44 4572 -693
RAB4B -7808 7089
RAB5B 3295 7820
RAB5C 7846 9422
RAB6A 8487 8616
RAB7A 8897 9367
RAB9B -5682 -4620
RAC1 9052 9614
RAP1A 8688 6973
RAP1B -2703 4941
RAP2B -6678 3725
RAP2C 426 5484
RETN 9209 9105
RHOA 8351 8888
RHOF -11160 -10418
RHOG 7549 9255
RNASE2 10073 10107
RNASE3 9238 6921
RNASET2 5158 6487
ROCK1 8315 7930
S100A11 9254 9466
S100A12 10088 10121
S100A8 10041 10093
S100A9 10110 10116
S100P 5927 9300
SCAMP1 7532 -1630
SDCBP 9944 9687
SELL 9694 9159
SERPINA1 9571 9817
SERPINB1 10061 9986
SERPINB10 9936 8636
SERPINB6 3579 7946
SIGLEC14 8633 4157
SIGLEC5 8330 8707
SIGLEC9 9722 10062
SIRPA 10106 10119
SIRPB1 7638 9107
SLC11A1 9129 9947
SLC15A4 -8597 6968
SLC27A2 6501 -6385
SLC2A3 9614 9612
SLC2A5 7731 -721
SLC44A2 -8609 5338
SLCO4C1 -10306 5158
SLPI 9291 3565
SNAP23 9586 8642
SNAP29 -1741 8902
SPTAN1 -10174 -8889
SRP14 4915 7324
STBD1 3893 5802
STING1 6507 4536
STK10 -10951 4288
STK11IP -6497 6947
STOM 1151 7088
SURF4 3781 8016
SVIP 4431 1345
SYNGR1 -8211 -736
TARM1 8354 4978
TBC1D10C -10716 -9378
TCIRG1 1085 9058
TCN1 8724 3700
TICAM2 9182 4768
TIMP2 9988 10081
TLR2 9930 9118
TMBIM1 6724 9228
TMC6 -8623 -9689
TMEM179B 821 1646
TMEM30A 9288 7807
TMEM63A -1958 -10069
TNFAIP6 8375 9294
TNFRSF1B 1146 8282
TOLLIP 8447 9165
TOM1 9299 9952
TRAPPC1 5277 9110
TRPM2 9480 9785
TSPAN14 -706 8468
TUBB -9096 -626
TUBB4B 6246 7789
TXNDC5 6834 -3539
TYROBP 6139 8494
UBR4 -6416 1703
UNC13D -1509 9298
VAMP8 2890 6767
VAPA 9732 9322
VAT1 9437 10049
VCL 7488 7955
VCP 3600 7754
VNN1 9174 9668
VPS35L 5526 7038
XRCC5 6475 5318
XRCC6 -2658 -1055
YPEL5 7863 6331



Insulin receptor recycling

Insulin receptor recycling
metric value
setSize 21
pMANOVA 1.06e-05
p.adjustMANOVA 7.03e-05
s.dist 0.766
s.low.CRP 0.535
s.high.CRP 0.549
p.low.CRP 2.22e-05
p.high.CRP 1.32e-05




Top 20 genes
Gene low CRP high CRP
ATP6V0A1 9995 10010
ATP6V1A 9857 9880
ATP6V0D1 9444 9942
ATP6V1D 9600 9482
ATP6V0C 9348 9734
ATP6V1B2 9738 9281
ATP6V1C1 9888 8528
INSR 9014 8953
ATP6V0B 8163 9396
ATP6V0E1 8171 9289
ATP6V1H 7942 8571
ATP6V1E1 8095 8397
ATP6V1E2 8322 4968
ATP6V1F 3461 6917
ATP6V1G1 5204 4277
ATP6AP1 2039 9790
TCIRG1 1085 9058

Click HERE to show all gene set members

All member genes
low CRP high CRP
ATP6AP1 2039 9790
ATP6V0A1 9995 10010
ATP6V0A2 -10623 -10379
ATP6V0B 8163 9396
ATP6V0C 9348 9734
ATP6V0D1 9444 9942
ATP6V0E1 8171 9289
ATP6V0E2 -8802 -11036
ATP6V1A 9857 9880
ATP6V1B2 9738 9281
ATP6V1C1 9888 8528
ATP6V1C2 2655 -3376
ATP6V1D 9600 9482
ATP6V1E1 8095 8397
ATP6V1E2 8322 4968
ATP6V1F 3461 6917
ATP6V1G1 5204 4277
ATP6V1G2 -4714 -10140
ATP6V1H 7942 8571
INSR 9014 8953
TCIRG1 1085 9058



MET activates RAP1 and RAC1

MET activates RAP1 and RAC1
metric value
setSize 10
pMANOVA 0.00402
p.adjustMANOVA 0.012
s.dist 0.761
s.low.CRP 0.487
s.high.CRP 0.585
p.low.CRP 0.00765
p.high.CRP 0.00137




Top 20 genes
Gene low CRP high CRP
GRB2 9631 9985
CRK 9657 9429
HGF 9753 8929
RAC1 9052 9614
RAP1A 8688 6973
GAB1 7926 5272
CRKL 1263 5754

Click HERE to show all gene set members

All member genes
low CRP high CRP
CRK 9657 9429
CRKL 1263 5754
DOCK7 3907 -3094
GAB1 7926 5272
GRB2 9631 9985
HGF 9753 8929
RAC1 9052 9614
RAP1A 8688 6973
RAP1B -2703 4941
RAPGEF1 -10851 -864



Dissolution of Fibrin Clot

Dissolution of Fibrin Clot
metric value
setSize 12
pMANOVA 0.00184
p.adjustMANOVA 0.00622
s.dist 0.752
s.low.CRP 0.531
s.high.CRP 0.533
p.low.CRP 0.00145
p.high.CRP 0.0014




Top 20 genes
Gene low CRP high CRP
SERPINB2 10012 9937
SERPINB8 9836 9348
ANXA2 8647 9102
PLAUR 8428 9009
SERPINE1 7839 8101
S100A10 6664 7533
SERPINE2 4786 6914
SERPINB6 3579 7946
PLAU 1698 5458

Click HERE to show all gene set members

All member genes
low CRP high CRP
ANXA2 8647 9102
PLAT 6118 -4882
PLAU 1698 5458
PLAUR 8428 9009
PLG 1277 -2998
S100A10 6664 7533
SERPINB2 10012 9937
SERPINB6 3579 7946
SERPINB8 9836 9348
SERPINE1 7839 8101
SERPINE2 4786 6914
SERPINF2 -7666 -3830



RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases
metric value
setSize 21
pMANOVA 1.52e-05
p.adjustMANOVA 9.29e-05
s.dist 0.733
s.low.CRP 0.442
s.high.CRP 0.584
p.low.CRP 0.000458
p.high.CRP 3.52e-06




Top 20 genes
Gene low CRP high CRP
S100A9 10110 10116
S100A8 10041 10093
NCF4 9697 9856
MAPK14 9907 9606
NCF2 9748 9694
PRKCD 9393 9642
CYBB 9900 8910
RAC1 9052 9614
MAPK3 8931 9626
NCF1 8576 7083
PRKCB 5395 8378
MAPK11 7257 1843
MAPK1 1052 9260
PIK3C3 6605 573
PRKCA 2473 1229

Click HERE to show all gene set members

All member genes
low CRP high CRP
CYBA -48 8901
CYBB 9900 8910
MAPK1 1052 9260
MAPK11 7257 1843
MAPK14 9907 9606
MAPK3 8931 9626
NCF1 8576 7083
NCF2 9748 9694
NCF4 9697 9856
NOXA1 -2600 -5589
PIK3C3 6605 573
PIK3R4 -267 -2209
PIN1 -9660 3728
PRKCA 2473 1229
PRKCB 5395 8378
PRKCD 9393 9642
PRKCZ -10855 -7708
RAC1 9052 9614
RAC2 -7677 6828
S100A8 10041 10093
S100A9 10110 10116



COPI-independent Golgi-to-ER retrograde traffic

COPI-independent Golgi-to-ER retrograde traffic
metric value
setSize 33
pMANOVA 2.25e-08
p.adjustMANOVA 3.13e-07
s.dist 0.729
s.low.CRP 0.426
s.high.CRP 0.592
p.low.CRP 2.29e-05
p.high.CRP 4.03e-09




Top 20 genes
Gene low CRP high CRP
PLA2G4A 9622 10024
DCTN2 8504 10012
GALNT2 8571 9697
CAPZA2 9698 8474
BICD2 8006 9959
DCTN4 7967 9572
CAPZA1 8666 8511
RAB6A 8487 8616
RAB18 9425 7287
DYNC1I2 8160 8196
ACTR10 8589 7569
DCTN6 7871 7759
PAFAH1B2 7693 7761
DYNC1LI1 7894 6997
CAPZB 6100 8926
GALNT1 7249 6590
RAB6B 6925 6712
RAB3GAP1 8630 5252
DYNLL1 6026 6499
AGPAT3 6352 4771

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACTR10 8589 7569
ACTR1A -2833 8680
AGPAT3 6352 4771
BICD1 -8225 -5006
BICD2 8006 9959
CAPZA1 8666 8511
CAPZA2 9698 8474
CAPZB 6100 8926
DCTN1 -5984 7873
DCTN2 8504 10012
DCTN3 325 7904
DCTN4 7967 9572
DCTN5 -7505 664
DCTN6 7871 7759
DYNC1H1 -8881 -2533
DYNC1I1 7141 2722
DYNC1I2 8160 8196
DYNC1LI1 7894 6997
DYNC1LI2 3494 5636
DYNLL1 6026 6499
DYNLL2 -6325 -225
GALNT1 7249 6590
GALNT2 8571 9697
PAFAH1B1 -336 6894
PAFAH1B2 7693 7761
PAFAH1B3 5824 4526
PLA2G4A 9622 10024
PLA2G6 -10753 -10993
RAB18 9425 7287
RAB3GAP1 8630 5252
RAB3GAP2 4746 4797
RAB6A 8487 8616
RAB6B 6925 6712



Detoxification of Reactive Oxygen Species

Detoxification of Reactive Oxygen Species
metric value
setSize 31
pMANOVA 5.24e-08
p.adjustMANOVA 6.67e-07
s.dist 0.728
s.low.CRP 0.417
s.high.CRP 0.597
p.low.CRP 5.93e-05
p.high.CRP 8.44e-09




Top 20 genes
Gene low CRP high CRP
PRDX3 9960 9672
NCF4 9697 9856
GPX1 9948 9589
GSR 9580 9896
NCF2 9748 9694
CAT 9793 9327
CYBB 9900 8910
ERO1A 9991 8671
PRDX6 9609 8969
TXN 8317 8729
TXNRD1 8327 8699
PRDX5 7625 9448
TXNRD2 8815 7221
P4HB 6474 9641
NCF1 8576 7083
PRDX1 8521 6488
SOD2 4529 4854
PRDX2 6558 2663
TXN2 101 6323
NUDT2 73 4724

Click HERE to show all gene set members

All member genes
low CRP high CRP
ATOX1 -3567 6465
ATP7A -5957 3433
CAT 9793 9327
CCS -2092 3750
CYBA -48 8901
CYBB 9900 8910
CYCS 1400 -430
ERO1A 9991 8671
GPX1 9948 9589
GPX2 -4296 -1665
GPX3 -7933 4657
GPX7 -8760 -6267
GSR 9580 9896
GSTP1 -3317 2661
NCF1 8576 7083
NCF2 9748 9694
NCF4 9697 9856
NOX5 -59 1956
NUDT2 73 4724
P4HB 6474 9641
PRDX1 8521 6488
PRDX2 6558 2663
PRDX3 9960 9672
PRDX5 7625 9448
PRDX6 9609 8969
SOD1 -1389 -3334
SOD2 4529 4854
TXN 8317 8729
TXN2 101 6323
TXNRD1 8327 8699
TXNRD2 8815 7221



Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade
metric value
setSize 23
pMANOVA 1.11e-05
p.adjustMANOVA 7.23e-05
s.dist 0.725
s.low.CRP 0.476
s.high.CRP 0.548
p.low.CRP 7.78e-05
p.high.CRP 5.43e-06




Top 20 genes
Gene low CRP high CRP
CD36 10064 9814
TLR5 9746 9721
CD14 9551 9658
TLR4 9494 9617
TLR2 9930 9118
TLR6 9634 9209
TLR1 9828 8868
LY96 9529 8995
MYD88 8651 8344
CHUK 9198 7663
BTK 7623 7870
NFKBIA 6855 7374
NFKB1 7857 6377
TICAM1 6742 6552
TIRAP 262 7730

Click HERE to show all gene set members

All member genes
low CRP high CRP
BTK 7623 7870
CD14 9551 9658
CD36 10064 9814
CHUK 9198 7663
IKBKB -5276 -2118
IKBKG -3058 7903
LY96 9529 8995
MYD88 8651 8344
NFKB1 7857 6377
NFKB2 3069 -1167
NFKBIA 6855 7374
RELA -7305 2739
TICAM1 6742 6552
TIRAP 262 7730
TLR1 9828 8868
TLR10 -122 -3607
TLR2 9930 9118
TLR3 -9935 -9836
TLR4 9494 9617
TLR5 9746 9721
TLR6 9634 9209
TRAF3 2694 -5265
UNC93B1 -1309 6224



Diseases of Immune System

Diseases of Immune System
metric value
setSize 23
pMANOVA 1.11e-05
p.adjustMANOVA 7.23e-05
s.dist 0.725
s.low.CRP 0.476
s.high.CRP 0.548
p.low.CRP 7.78e-05
p.high.CRP 5.43e-06




Top 20 genes
Gene low CRP high CRP
CD36 10064 9814
TLR5 9746 9721
CD14 9551 9658
TLR4 9494 9617
TLR2 9930 9118
TLR6 9634 9209
TLR1 9828 8868
LY96 9529 8995
MYD88 8651 8344
CHUK 9198 7663
BTK 7623 7870
NFKBIA 6855 7374
NFKB1 7857 6377
TICAM1 6742 6552
TIRAP 262 7730

Click HERE to show all gene set members

All member genes
low CRP high CRP
BTK 7623 7870
CD14 9551 9658
CD36 10064 9814
CHUK 9198 7663
IKBKB -5276 -2118
IKBKG -3058 7903
LY96 9529 8995
MYD88 8651 8344
NFKB1 7857 6377
NFKB2 3069 -1167
NFKBIA 6855 7374
RELA -7305 2739
TICAM1 6742 6552
TIRAP 262 7730
TLR1 9828 8868
TLR10 -122 -3607
TLR2 9930 9118
TLR3 -9935 -9836
TLR4 9494 9617
TLR5 9746 9721
TLR6 9634 9209
TRAF3 2694 -5265
UNC93B1 -1309 6224



Platelet Adhesion to exposed collagen

Platelet Adhesion to exposed collagen
metric value
setSize 13
pMANOVA 0.00131
p.adjustMANOVA 0.00462
s.dist 0.724
s.low.CRP 0.572
s.high.CRP 0.443
p.low.CRP 0.000356
p.high.CRP 0.00566




Top 20 genes
Gene low CRP high CRP
ITGA1 9674 8579
GP9 7524 8518
LYN 7575 8379
GP1BB 7053 8670
FCER1G 6595 9147
GP6 7137 7699
VWF 6949 7780
GP1BA 6335 6875

Click HERE to show all gene set members

All member genes
low CRP high CRP
FCER1G 6595 9147
FYN -10878 -6729
GP1BA 6335 6875
GP1BB 7053 8670
GP5 6641 -1822
GP6 7137 7699
GP9 7524 8518
ITGA1 9674 8579
ITGA10 5196 -2609
ITGA2 8852 -28
ITGB1 3360 -108
LYN 7575 8379
VWF 6949 7780



Hyaluronan metabolism

Hyaluronan metabolism
metric value
setSize 15
pMANOVA 0.000847
p.adjustMANOVA 0.00324
s.dist 0.702
s.low.CRP 0.446
s.high.CRP 0.543
p.low.CRP 0.0028
p.high.CRP 0.000274




Top 20 genes
Gene low CRP high CRP
CHP1 9390 10098
HEXB 9386 9202
LYVE1 8853 9498
HYAL2 8387 9968
CD44 8303 9047
STAB2 7035 5388
HYAL3 7507 4690
SLC9A1 3224 9393
GUSB 2374 9501
HMMR 1918 3372
ABCC5 1929 3348
HYAL1 888 4763
HEXA 1650 2356

Click HERE to show all gene set members

All member genes
low CRP high CRP
ABCC5 1929 3348
CD44 8303 9047
CEMIP -552 -9225
CHP1 9390 10098
GUSB 2374 9501
HAS3 -7457 -2746
HEXA 1650 2356
HEXB 9386 9202
HMMR 1918 3372
HYAL1 888 4763
HYAL2 8387 9968
HYAL3 7507 4690
LYVE1 8853 9498
SLC9A1 3224 9393
STAB2 7035 5388



EPHB-mediated forward signaling

EPHB-mediated forward signaling
metric value
setSize 32
pMANOVA 4.26e-07
p.adjustMANOVA 4.63e-06
s.dist 0.702
s.low.CRP 0.482
s.high.CRP 0.511
p.low.CRP 2.4e-06
p.high.CRP 5.7e-07




Top 20 genes
Gene low CRP high CRP
ITSN1 9969 9600
ARPC1B 9259 10026
ACTB 9310 9714
RAC1 9052 9614
ARPC5 9301 9174
ARPC1A 8875 9605
ARPC3 8430 8946
PAK1 9711 7682
RHOA 8351 8888
ACTG1 7674 9499
ACTR2 8743 7962
LIMK2 8349 8299
ACTR3 8622 7832
ROCK1 8315 7930
CDC42 8498 7640
LYN 7575 8379
CFL1 5851 9242
ROCK2 7628 6719
ARPC2 5327 8212
ARPC4 4637 8915

Click HERE to show all gene set members

All member genes
low CRP high CRP
ACTB 9310 9714
ACTG1 7674 9499
ACTR2 8743 7962
ACTR3 8622 7832
ARHGEF28 -10356 -6123
ARPC1A 8875 9605
ARPC1B 9259 10026
ARPC2 5327 8212
ARPC3 8430 8946
ARPC4 4637 8915
ARPC5 9301 9174
CDC42 8498 7640
CFL1 5851 9242
FYN -10878 -6729
HRAS -2248 -1932
ITSN1 9969 9600
KALRN 999 -4389
LIMK1 -2747 6617
LIMK2 8349 8299
LYN 7575 8379
PAK1 9711 7682
PTK2 7786 3481
RAC1 9052 9614
RASA1 4308 2428
RHOA 8351 8888
ROCK1 8315 7930
ROCK2 7628 6719
SDC2 7232 4710
SRC -6857 -7229
TIAM1 5732 -809
WASL 899 1391
YES1 -11138 -8566



NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus
metric value
setSize 10
pMANOVA 0.00392
p.adjustMANOVA 0.0117
s.dist 0.699
s.low.CRP 0.346
s.high.CRP 0.607
p.low.CRP 0.0578
p.high.CRP 0.000888




Top 20 genes
Gene low CRP high CRP
NCSTN 9503 9869
ADAM10 9314 9481
JAG1 9550 8956
PSEN1 7889 8878
APH1B 6306 6678
YWHAZ 5165 5861
PSENEN 2692 7551

Click HERE to show all gene set members

All member genes
low CRP high CRP
ADAM10 9314 9481
APH1A -3379 6321
APH1B 6306 6678
JAG1 9550 8956
NCSTN 9503 9869
NOTCH4 -10586 1602
PSEN1 7889 8878
PSEN2 -5169 -5867
PSENEN 2692 7551
YWHAZ 5165 5861



IRAK1 recruits IKK complex

IRAK1 recruits IKK complex
metric value
setSize 10
pMANOVA 0.0081
p.adjustMANOVA 0.0214
s.dist 0.687
s.low.CRP 0.393
s.high.CRP 0.564
p.low.CRP 0.0312
p.high.CRP 0.00202




Top 20 genes
Gene low CRP high CRP
PELI2 9242 9060
CHUK 9198 7663
PELI1 9064 5690
PELI3 5708 8764
UBE2V1 6665 5995
IRAK1 2444 7601
UBE2N 4087 2050

Click HERE to show all gene set members

All member genes
low CRP high CRP
CHUK 9198 7663
IKBKB -5276 -2118
IKBKG -3058 7903
IRAK1 2444 7601
PELI1 9064 5690
PELI2 9242 9060
PELI3 5708 8764
TRAF6 -1767 2089
UBE2N 4087 2050
UBE2V1 6665 5995



IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
metric value
setSize 10
pMANOVA 0.0081
p.adjustMANOVA 0.0214
s.dist 0.687
s.low.CRP 0.393
s.high.CRP 0.564
p.low.CRP 0.0312
p.high.CRP 0.00202




Top 20 genes
Gene low CRP high CRP
PELI2 9242 9060
CHUK 9198 7663
PELI1 9064 5690
PELI3 5708 8764
UBE2V1 6665 5995
IRAK1 2444 7601
UBE2N 4087 2050

Click HERE to show all gene set members

All member genes
low CRP high CRP
CHUK 9198 7663
IKBKB -5276 -2118
IKBKG -3058 7903
IRAK1 2444 7601
PELI1 9064 5690
PELI2 9242 9060
PELI3 5708 8764
TRAF6 -1767 2089
UBE2N 4087 2050
UBE2V1 6665 5995



Retrograde neurotrophin signalling

Retrograde neurotrophin signalling
metric value
setSize 12
pMANOVA 0.000584
p.adjustMANOVA 0.00231
s.dist 0.682
s.low.CRP 0.269
s.high.CRP 0.626
p.low.CRP 0.106
p.high.CRP 0.000173




Top 20 genes
Gene low CRP high CRP
CLTC 9376 9720
CLTA 8416 8998
AP2M1 7742 9334
AP2S1 7422 8877
DNM3 7927 7198
AP2A2 3196 9217
DNM1 6883 3239

Click HERE to show all gene set members

All member genes
low CRP high CRP
AP2A1 -3194 9104
AP2A2 3196 9217
AP2B1 -9145 2444
AP2M1 7742 9334
AP2S1 7422 8877
CLTA 8416 8998
CLTC 9376 9720
DNAL4 -697 5475
DNM1 6883 3239
DNM2 -6816 8202
DNM3 7927 7198
NTRK1 -3499 -8157



Cargo concentration in the ER

Cargo concentration in the ER
metric value
setSize 30
pMANOVA 1.44e-06
p.adjustMANOVA 1.32e-05
s.dist 0.681
s.low.CRP 0.423
s.high.CRP 0.534
p.low.CRP 6.09e-05
p.high.CRP 4.19e-07




Top 20 genes
Gene low CRP high CRP
F5 10084 10070
SERPINA1 9571 9817
CTSZ 8972 9860
TGFA 7935 9686
SEC24D 8017 8795
CNIH1 9316 7116
SEC24A 8318 7788
SEC23A 8776 6905
MCFD2 7963 7485
F8 7498 7167
SAR1B 8795 5984
LMAN2L 7675 6680
SEC22B 8663 4943
TMED2 6426 6360
MIA2 6640 5566
AREG 4465 7165
COL7A1 3993 7683
STX5 3566 8258
CD59 4075 5772
LMAN2 2397 8522

Click HERE to show all gene set members

All member genes
low CRP high CRP
AREG 4465 7165
CD59 4075 5772
CNIH1 9316 7116
CNIH2 701 601
CNIH3 -8173 -6989
COL7A1 3993 7683
CTSC -7528 5285
CTSZ 8972 9860
F5 10084 10070
F8 7498 7167
GOSR2 -2437 1468
LMAN1 -1255 -10522
LMAN2 2397 8522
LMAN2L 7675 6680
MCFD2 7963 7485
MIA2 6640 5566
MIA3 3397 -6425
PREB -1638 8142
SAR1B 8795 5984
SEC22B 8663 4943
SEC23A 8776 6905
SEC24A 8318 7788
SEC24B 1663 5398
SEC24C -9662 3561
SEC24D 8017 8795
SERPINA1 9571 9817
STX5 3566 8258
TGFA 7935 9686
TMED10 35 2168
TMED2 6426 6360



Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization
metric value
setSize 14
pMANOVA 0.00158
p.adjustMANOVA 0.00541
s.dist 0.679
s.low.CRP 0.399
s.high.CRP 0.549
p.low.CRP 0.00969
p.high.CRP 0.000377




Top 20 genes
Gene low CRP high CRP
RAB1A 9700 9407
MAPK3 8931 9626
RAB2A 9085 9113
RAB1B 5676 9455
GORASP1 7651 6560
USO1 6916 3905
BLZF1 6528 2548
MAPK1 1052 9260

Click HERE to show all gene set members

All member genes
low CRP high CRP
BLZF1 6528 2548
CCNB1 -1008 682
CCNB2 -1938 5031
CDK1 4994 -360
GOLGA2 -878 8019
GORASP1 7651 6560
GORASP2 -4780 -3181
MAPK1 1052 9260
MAPK3 8931 9626
PLK1 -235 4265
RAB1A 9700 9407
RAB1B 5676 9455
RAB2A 9085 9113
USO1 6916 3905



GRB2 events in EGFR signaling

GRB2 events in EGFR signaling
metric value
setSize 10
pMANOVA 0.0135
p.adjustMANOVA 0.0326
s.dist 0.678
s.low.CRP 0.502
s.high.CRP 0.456
p.low.CRP 0.00598
p.high.CRP 0.0125




Top 20 genes
Gene low CRP high CRP
GRB2 9631 9985
EGF 9244 8355
TGFA 7935 9686
NRAS 7321 4878
AREG 4465 7165
HBEGF 5089 5189
KRAS 3789 4070

Click HERE to show all gene set members

All member genes
low CRP high CRP
AREG 4465 7165
EGF 9244 8355
EREG -837 3226
GRB2 9631 9985
HBEGF 5089 5189
HRAS -2248 -1932
KRAS 3789 4070
NRAS 7321 4878
SOS1 3534 -7412
TGFA 7935 9686



The NLRP3 inflammasome

The NLRP3 inflammasome
metric value
setSize 15
pMANOVA 0.0015
p.adjustMANOVA 0.00515
s.dist 0.677
s.low.CRP 0.515
s.high.CRP 0.439
p.low.CRP 0.000556
p.high.CRP 0.00322




Top 20 genes
Gene low CRP high CRP
APP 9951 9504
NLRP3 9708 8944
MEFV 9094 9246
PYCARD 8329 9425
TXN 8317 8729
NFKB1 7857 6377
PANX1 6263 6597
PSTPIP1 4146 9452
CASP1 8236 2513
P2RX7 5741 3066

Click HERE to show all gene set members

All member genes
low CRP high CRP
APP 9951 9504
CASP1 8236 2513
HSP90AB1 2247 -6319
MEFV 9094 9246
NFKB1 7857 6377
NFKB2 3069 -1167
NLRP3 9708 8944
P2RX7 5741 3066
PANX1 6263 6597
PSTPIP1 4146 9452
PYCARD 8329 9425
RELA -7305 2739
SUGT1 7602 -482
TXN 8317 8729
TXNIP -9337 -6548



Pentose phosphate pathway

Pentose phosphate pathway
metric value
setSize 13
pMANOVA 0.00327
p.adjustMANOVA 0.01
s.dist 0.677
s.low.CRP 0.425
s.high.CRP 0.526
p.low.CRP 0.00794
p.high.CRP 0.00101




Top 20 genes
Gene low CRP high CRP
PGD 10065 10089
TALDO1 10039 9995
PGM2 9878 9866
TKT 9790 9907
G6PD 8451 9963
DERA 9044 8799
PGLS 2615 7428
PRPS2 8155 2205
RPIA 4409 1808

Click HERE to show all gene set members

All member genes
low CRP high CRP
DERA 9044 8799
G6PD 8451 9963
PGD 10065 10089
PGLS 2615 7428
PGM2 9878 9866
PRPS1 -10387 -10439
PRPS2 8155 2205
RBKS -7050 1601
RPE -569 4180
RPIA 4409 1808
SHPK -2824 521
TALDO1 10039 9995
TKT 9790 9907



Platelet sensitization by LDL

Platelet sensitization by LDL
metric value
setSize 16
pMANOVA 0.00012
p.adjustMANOVA 0.000568
s.dist 0.675
s.low.CRP 0.298
s.high.CRP 0.606
p.low.CRP 0.0392
p.high.CRP 2.69e-05




Top 20 genes
Gene low CRP high CRP
PLA2G4A 9622 10024
MAPK14 9907 9606
PPP2CA 8810 8328
PECAM1 8136 8308
PPP2CB 8482 7631
FGR 6254 9666
PPP2R5B 5288 7952
PTPN11 4691 6614
PPP2R1B 2503 437
PPP2R5E 715 540

Click HERE to show all gene set members

All member genes
low CRP high CRP
FGR 6254 9666
LRP8 -1100 5967
MAPK14 9907 9606
PECAM1 8136 8308
PLA2G4A 9622 10024
PPP2CA 8810 8328
PPP2CB 8482 7631
PPP2R1A -3087 6994
PPP2R1B 2503 437
PPP2R5A -903 6957
PPP2R5B 5288 7952
PPP2R5C -10420 -7112
PPP2R5D -6508 4985
PPP2R5E 715 540
PTPN11 4691 6614
PTPN6 -691 7862



Transferrin endocytosis and recycling

Transferrin endocytosis and recycling
metric value
setSize 26
pMANOVA 1.93e-05
p.adjustMANOVA 0.000116
s.dist 0.67
s.low.CRP 0.457
s.high.CRP 0.489
p.low.CRP 5.48e-05
p.high.CRP 1.56e-05




Top 20 genes
Gene low CRP high CRP
ATP6V0A1 9995 10010
ATP6V1A 9857 9880
ATP6V0D1 9444 9942
ATP6V1D 9600 9482
ATP6V0C 9348 9734
ATP6V1B2 9738 9281
ATP6V1C1 9888 8528
ATP6V0B 8163 9396
ATP6V0E1 8171 9289
HFE 10047 7215
ATP6V1H 7942 8571
ATP6V1E1 8095 8397
MCOLN1 6111 8804
ATP6V1E2 8322 4968
ATP6V1F 3461 6917
ATP6V1G1 5204 4277
ATP6AP1 2039 9790
STEAP3 1711 7554
TCIRG1 1085 9058
TFRC 2181 1526

Click HERE to show all gene set members

All member genes
low CRP high CRP
ATP6AP1 2039 9790
ATP6V0A1 9995 10010
ATP6V0A2 -10623 -10379
ATP6V0B 8163 9396
ATP6V0C 9348 9734
ATP6V0D1 9444 9942
ATP6V0E1 8171 9289
ATP6V0E2 -8802 -11036
ATP6V1A 9857 9880
ATP6V1B2 9738 9281
ATP6V1C1 9888 8528
ATP6V1C2 2655 -3376
ATP6V1D 9600 9482
ATP6V1E1 8095 8397
ATP6V1E2 8322 4968
ATP6V1F 3461 6917
ATP6V1G1 5204 4277
ATP6V1G2 -4714 -10140
ATP6V1H 7942 8571
HFE 10047 7215
MCOLN1 6111 8804
STEAP3 1711 7554
TCIRG1 1085 9058
TF 1794 1244
TFR2 -8721 -7475
TFRC 2181 1526



PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
metric value
setSize 13
pMANOVA 0.000994
p.adjustMANOVA 0.00365
s.dist 0.669
s.low.CRP 0.312
s.high.CRP 0.592
p.low.CRP 0.0514
p.high.CRP 0.000219




Top 20 genes
Gene low CRP high CRP
CRK 9657 9429
RAC1 9052 9614
RHOA 8351 8888
DOCK1 6941 8390
PTK6 6593 5974
NRAS 7321 4878
ELMO1 4243 7282
KRAS 3789 4070
RASA1 4308 2428

Click HERE to show all gene set members

All member genes
low CRP high CRP
ARHGAP35 -6993 1378
CRK 9657 9429
DOCK1 6941 8390
ELMO1 4243 7282
ELMO2 -9506 6592
HRAS -2248 -1932
KRAS 3789 4070
NRAS 7321 4878
PTK6 6593 5974
PXN -5634 8031
RAC1 9052 9614
RASA1 4308 2428
RHOA 8351 8888



DNA methylation

DNA methylation
metric value
setSize 20
pMANOVA 0.000138
p.adjustMANOVA 0.000642
s.dist 0.668
s.low.CRP 0.395
s.high.CRP 0.539
p.low.CRP 0.00221
p.high.CRP 3.05e-05




Top 20 genes
Gene low CRP high CRP
H2BC21 9852.0 9656.0
H2AJ 8999.0 10117.0
H2BC12 9066.0 9812.0
H3-3A 9297.0 9034.0
H2AC6 8700.0 8169.0
H2BC11 8424.0 8288.0
H2BC5 7596.0 8773.0
H2BC17 7882.0 7312.0
H2BC4 7156.0 7805.0
H3C15 5262.5 7402.5
H2BC9 7965.0 4715.0
DNMT3B 5487.0 4173.0
H2BC15 3036.0 6455.0
H2AZ1 1779.0 7321.0

Click HERE to show all gene set members

All member genes
low CRP high CRP
DNMT1 -10726.0 -10916.0
DNMT3A -3948.0 -310.0
DNMT3B 5487.0 4173.0
H2AC20 -790.0 6112.0
H2AC6 8700.0 8169.0
H2AJ 8999.0 10117.0
H2AZ1 1779.0 7321.0
H2AZ2 -4042.0 2210.0
H2BC11 8424.0 8288.0
H2BC12 9066.0 9812.0
H2BC15 3036.0 6455.0
H2BC17 7882.0 7312.0
H2BC21 9852.0 9656.0
H2BC4 7156.0 7805.0
H2BC5 7596.0 8773.0
H2BC9 7965.0 4715.0
H2BU1 -6349.0 -3895.0
H3-3A 9297.0 9034.0
H3C15 5262.5 7402.5
UHRF1 -1659.0 1734.0



RHO GTPases Activate ROCKs

RHO GTPases Activate ROCKs
metric value
setSize 18
pMANOVA 8.93e-05
p.adjustMANOVA 0.000443
s.dist 0.663
s.low.CRP 0.313
s.high.CRP 0.585
p.low.CRP 0.0213
p.high.CRP 1.74e-05




Top 20 genes
Gene low CRP high CRP
MYL9 9640 7741
PAK1 9711 7682
RHOA 8351 8888
LIMK2 8349 8299
ROCK1 8315 7930
MYL6 6786 9643
PPP1CB 8657 6666
CFL1 5851 9242
ROCK2 7628 6719
PPP1R12A 5601 6368
MYH9 1879 8348

Click HERE to show all gene set members

All member genes
low CRP high CRP
CFL1 5851 9242
LIMK1 -2747 6617
LIMK2 8349 8299
MYH10 -7101 3044
MYH11 1903 -4778
MYH9 1879 8348
MYL12B -2612 6816
MYL6 6786 9643
MYL9 9640 7741
PAK1 9711 7682
PPP1CB 8657 6666
PPP1R12A 5601 6368
PPP1R12B -4326 4036
RHOA 8351 8888
RHOB -4807 3859
RHOC -11158 -4627
ROCK1 8315 7930
ROCK2 7628 6719



Gap junction trafficking

Gap junction trafficking
metric value
setSize 13
pMANOVA 0.000855
p.adjustMANOVA 0.00326
s.dist 0.66
s.low.CRP 0.288
s.high.CRP 0.594
p.low.CRP 0.072
p.high.CRP 0.000208




Top 20 genes
Gene low CRP high CRP
CLTCL1 10011 9218
CLTC 9376 9720
CLTA 8416 8998
AP2M1 7742 9334
GJD3 8186 8611
DAB2 3735 9712
DNM1 6883 3239
GJC2 1419 2222

Click HERE to show all gene set members

All member genes
low CRP high CRP
AP2M1 7742 9334
CLTA 8416 8998
CLTB -2857 8274
CLTC 9376 9720
CLTCL1 10011 9218
DAB2 3735 9712
DNM1 6883 3239
DNM2 -6816 8202
GJB6 -2646 5614
GJC1 -382 1106
GJC2 1419 2222
GJD3 8186 8611
MYO6 -10507 -8938



Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
metric value
setSize 20
pMANOVA 0.000174
p.adjustMANOVA 0.00079
s.dist 0.66
s.low.CRP 0.392
s.high.CRP 0.531
p.low.CRP 0.00242
p.high.CRP 3.94e-05




Top 20 genes
Gene low CRP high CRP
LMNB1 9994 9773
APP 9951 9504
YWHAE 9721 9563
FOXO3 8202 9854
CDK5 8395 9380
CAST 8617 8824
CAPN1 7094 9770
BCL2L11 8059 7998
PRDX1 8521 6488
CAPNS1 5468 8812
SOD2 4529 4854
PRDX2 6558 2663
JUN 2838 4810
CDC25A 3970 2814
LMNA 1706 5027

Click HERE to show all gene set members

All member genes
low CRP high CRP
APP 9951 9504
BCL2L11 8059 7998
CAPN1 7094 9770
CAPN2 -829 2369
CAPNS1 5468 8812
CAST 8617 8824
CDC25A 3970 2814
CDC25B -10025 -11135
CDK5 8395 9380
CDK5R1 -8396 3375
FASLG -11268 -10430
FOXO3 8202 9854
GOLGA2 -878 8019
JUN 2838 4810
LMNA 1706 5027
LMNB1 9994 9773
PRDX1 8521 6488
PRDX2 6558 2663
SOD2 4529 4854
YWHAE 9721 9563



Neurodegenerative Diseases

Neurodegenerative Diseases
metric value
setSize 20
pMANOVA 0.000174
p.adjustMANOVA 0.00079
s.dist 0.66
s.low.CRP 0.392
s.high.CRP 0.531
p.low.CRP 0.00242
p.high.CRP 3.94e-05




Top 20 genes
Gene low CRP high CRP
LMNB1 9994 9773
APP 9951 9504
YWHAE 9721 9563
FOXO3 8202 9854
CDK5 8395 9380
CAST 8617 8824
CAPN1 7094 9770
BCL2L11 8059 7998
PRDX1 8521 6488
CAPNS1 5468 8812
SOD2 4529 4854
PRDX2 6558 2663
JUN 2838 4810
CDC25A 3970 2814
LMNA 1706 5027

Click HERE to show all gene set members

All member genes
low CRP high CRP
APP 9951 9504
BCL2L11 8059 7998
CAPN1 7094 9770
CAPN2 -829 2369
CAPNS1 5468 8812
CAST 8617 8824
CDC25A 3970 2814
CDC25B -10025 -11135
CDK5 8395 9380
CDK5R1 -8396 3375
FASLG -11268 -10430
FOXO3 8202 9854
GOLGA2 -878 8019
JUN 2838 4810
LMNA 1706 5027
LMNB1 9994 9773
PRDX1 8521 6488
PRDX2 6558 2663
SOD2 4529 4854
YWHAE 9721 9563



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.3             eulerr_6.1.0               
##  [7] mitch_1.2.2                 MASS_7.3-53                
##  [9] fgsea_1.16.0                gplots_3.1.0               
## [11] DESeq2_1.30.0               SummarizedExperiment_1.20.0
## [13] Biobase_2.50.0              MatrixGenerics_1.2.0       
## [15] matrixStats_0.57.0          GenomicRanges_1.42.0       
## [17] GenomeInfoDb_1.26.0         IRanges_2.24.0             
## [19] S4Vectors_0.28.0            BiocGenerics_0.36.0        
## [21] reshape2_1.4.4              forcats_0.5.0              
## [23] stringr_1.4.0               dplyr_1.0.2                
## [25] purrr_0.3.4                 readr_1.4.0                
## [27] tidyr_1.1.2                 tibble_3.0.4               
## [29] ggplot2_3.3.2               tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_2.0-0       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.30.0         fs_1.5.0               rstudioapi_0.12       
##  [7] farver_2.0.3           bit64_4.0.5            AnnotationDbi_1.52.0  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.3          geneplotter_1.68.0     knitr_1.30            
## [16] polyclip_1.10-0        jsonlite_1.7.1         broom_0.7.2           
## [19] annotate_1.68.0        dbplyr_2.0.0           shiny_1.5.0           
## [22] compiler_4.0.3         httr_1.4.2             backports_1.2.0       
## [25] assertthat_0.2.1       Matrix_1.2-18          fastmap_1.0.1         
## [28] cli_2.1.0              later_1.1.0.1          htmltools_0.5.0       
## [31] tools_4.0.3            gtable_0.3.0           glue_1.4.2            
## [34] GenomeInfoDbData_1.2.4 fastmatch_1.1-0        Rcpp_1.0.5            
## [37] cellranger_1.1.0       vctrs_0.3.4            polylabelr_0.2.0      
## [40] xfun_0.19              ps_1.4.0               testthat_3.0.0        
## [43] rvest_0.3.6            mime_0.9               lifecycle_0.2.0       
## [46] XML_3.99-0.5           zlibbioc_1.36.0        scales_1.1.1          
## [49] hms_0.5.3              promises_1.1.1         RColorBrewer_1.1-2    
## [52] yaml_2.2.1             memoise_1.1.0          gridExtra_2.3         
## [55] reshape_0.8.8          stringi_1.5.3          RSQLite_2.2.1         
## [58] highr_0.8              genefilter_1.72.0      desc_1.2.0            
## [61] caTools_1.18.0         BiocParallel_1.24.1    rlang_0.4.8           
## [64] pkgconfig_2.0.3        bitops_1.0-6           evaluate_0.14         
## [67] lattice_0.20-41        labeling_0.4.2         htmlwidgets_1.5.2     
## [70] bit_4.0.4              tidyselect_1.1.0       plyr_1.8.6            
## [73] magrittr_1.5           R6_2.5.0               generics_0.1.0        
## [76] DelayedArray_0.16.0    DBI_1.1.0              pillar_1.4.6          
## [79] haven_2.3.1            withr_2.3.0            survival_3.2-7        
## [82] RCurl_1.98-1.2         modelr_0.1.8           crayon_1.3.4          
## [85] KernSmooth_2.23-18     rmarkdown_2.5          locfit_1.5-9.4        
## [88] grid_4.0.3             readxl_1.3.1           data.table_1.13.2     
## [91] blob_1.2.1             reprex_0.3.0           digest_0.6.27         
## [94] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report