Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-11-12
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## low CRP high CRP
## A1BG 1.0864505 2.93660576
## A1BG-AS1 0.2363048 0.81097593
## A1CF 0.6265346 0.20979938
## A2M -1.1565132 -4.19066691
## A2M-AS1 -1.1830767 -3.99635746
## A2ML1 -0.3033644 -0.09097114Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 21404 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8378 |
| num_profile_genes_not_in_sets | 13026 |
| profile_pearson_correl | 0.66054 |
| profile_spearman_correl | 0.61532 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2408 |
| num_genesets_excluded | 1045 |
| num_genesets_included | 1363 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 639 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.low.CRP | s.high.CRP | p.low.CRP | p.high.CRP |
|---|---|---|---|---|---|---|---|---|
| CD22 mediated BCR regulation | 58 | 1.55e-15 | 9.58e-14 | 0.400 | 0.197000 | -0.3480 | 9.56e-03 | 4.59e-06 |
| VLDLR internalisation and degradation | 11 | 1.28e-04 | 6.00e-04 | 0.642 | 0.095400 | 0.6350 | 5.84e-01 | 2.66e-04 |
| Scavenging of heme from plasma | 70 | 2.16e-17 | 1.73e-15 | 0.376 | 0.250000 | -0.2800 | 2.92e-04 | 5.05e-05 |
| Classical antibody-mediated complement activation | 68 | 7.31e-15 | 3.56e-13 | 0.366 | 0.161000 | -0.3280 | 2.16e-02 | 2.87e-06 |
| Creation of C4 and C2 activators | 70 | 4.10e-15 | 2.43e-13 | 0.359 | 0.174000 | -0.3140 | 1.18e-02 | 5.41e-06 |
| Pre-NOTCH Processing in Golgi | 18 | 2.80e-05 | 1.61e-04 | 0.522 | 0.047900 | 0.5190 | 7.25e-01 | 1.36e-04 |
| tRNA processing in the mitochondrion | 32 | 1.76e-07 | 2.05e-06 | 0.410 | -0.405000 | 0.0665 | 7.36e-05 | 5.15e-01 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 73 | 4.31e-14 | 1.78e-12 | 0.329 | 0.230000 | -0.2360 | 6.84e-04 | 4.98e-04 |
| Nucleobase biosynthesis | 13 | 1.93e-03 | 6.45e-03 | 0.418 | 0.047300 | -0.4160 | 7.68e-01 | 9.46e-03 |
| FCGR activation | 75 | 3.32e-14 | 1.43e-12 | 0.342 | 0.143000 | -0.3110 | 3.22e-02 | 3.24e-06 |
| Initial triggering of complement | 77 | 3.37e-14 | 1.43e-12 | 0.332 | 0.158000 | -0.2920 | 1.65e-02 | 9.18e-06 |
| Purine ribonucleoside monophosphate biosynthesis | 10 | 1.67e-02 | 3.81e-02 | 0.351 | 0.113000 | -0.3320 | 5.35e-01 | 6.88e-02 |
| N-Glycan antennae elongation | 13 | 4.13e-03 | 1.22e-02 | 0.383 | -0.378000 | 0.0609 | 1.82e-02 | 7.04e-01 |
| Metabolism of amine-derived hormones | 10 | 1.80e-02 | 4.01e-02 | 0.380 | 0.046600 | -0.3780 | 7.99e-01 | 3.87e-02 |
| Binding and Uptake of Ligands by Scavenger Receptors | 91 | 9.23e-15 | 4.34e-13 | 0.314 | 0.280000 | -0.1420 | 3.95e-06 | 1.90e-02 |
| Pausing and recovery of Tat-mediated HIV elongation | 30 | 2.00e-05 | 1.19e-04 | 0.325 | -0.118000 | 0.3030 | 2.64e-01 | 4.10e-03 |
| Tat-mediated HIV elongation arrest and recovery | 30 | 2.00e-05 | 1.19e-04 | 0.325 | -0.118000 | 0.3030 | 2.64e-01 | 4.10e-03 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 11 | 1.20e-02 | 2.94e-02 | 0.398 | 0.016700 | -0.3980 | 9.24e-01 | 2.23e-02 |
| Regulation of TP53 Activity through Acetylation | 29 | 8.63e-06 | 5.77e-05 | 0.400 | -0.400000 | 0.0133 | 1.92e-04 | 9.01e-01 |
| ERKs are inactivated | 13 | 1.09e-03 | 3.94e-03 | 0.545 | 0.121000 | 0.5310 | 4.49e-01 | 9.15e-04 |
| Endosomal/Vacuolar pathway | 12 | 1.28e-02 | 3.11e-02 | 0.365 | -0.363000 | 0.0386 | 2.95e-02 | 8.17e-01 |
| HIV elongation arrest and recovery | 32 | 2.99e-05 | 1.68e-04 | 0.308 | -0.115000 | 0.2850 | 2.59e-01 | 5.25e-03 |
| Pausing and recovery of HIV elongation | 32 | 2.99e-05 | 1.68e-04 | 0.308 | -0.115000 | 0.2850 | 2.59e-01 | 5.25e-03 |
| Role of phospholipids in phagocytosis | 87 | 3.18e-12 | 9.22e-11 | 0.290 | 0.135000 | -0.2570 | 3.01e-02 | 3.51e-05 |
| WNT5A-dependent internalization of FZD4 | 13 | 9.68e-04 | 3.58e-03 | 0.578 | 0.165000 | 0.5540 | 3.02e-01 | 5.46e-04 |
| Regulation of Complement cascade | 93 | 1.56e-12 | 4.61e-11 | 0.274 | 0.203000 | -0.1850 | 7.10e-04 | 2.09e-03 |
| Complement cascade | 97 | 1.56e-12 | 4.61e-11 | 0.269 | 0.201000 | -0.1790 | 6.33e-04 | 2.33e-03 |
| HDMs demethylate histones | 22 | 1.45e-03 | 5.03e-03 | 0.325 | -0.044400 | 0.3220 | 7.19e-01 | 8.96e-03 |
| SUMOylation of immune response proteins | 11 | 7.14e-03 | 1.94e-02 | 0.522 | 0.139000 | 0.5030 | 4.25e-01 | 3.88e-03 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 23 | 2.22e-03 | 7.10e-03 | 0.284 | -0.088300 | 0.2700 | 4.64e-01 | 2.48e-02 |
| Retrograde neurotrophin signalling | 12 | 5.84e-04 | 2.31e-03 | 0.682 | 0.269000 | 0.6260 | 1.06e-01 | 1.73e-04 |
| FCERI mediated Ca+2 mobilization | 88 | 2.55e-10 | 5.18e-09 | 0.260 | 0.136000 | -0.2210 | 2.78e-02 | 3.34e-04 |
| FCERI mediated MAPK activation | 89 | 2.70e-10 | 5.39e-09 | 0.258 | 0.221000 | -0.1330 | 3.06e-04 | 3.02e-02 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 1.02e-04 | 4.96e-04 | 0.841 | 0.395000 | 0.7420 | 2.32e-02 | 2.01e-05 |
| GPVI-mediated activation cascade | 31 | 3.29e-05 | 1.79e-04 | 0.412 | 0.063200 | 0.4070 | 5.42e-01 | 8.70e-05 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | 15 | 1.58e-02 | 3.65e-02 | 0.338 | -0.000913 | 0.3380 | 9.95e-01 | 2.34e-02 |
| AKT phosphorylates targets in the cytosol | 14 | 2.16e-03 | 7.02e-03 | 0.541 | 0.176000 | 0.5110 | 2.54e-01 | 9.21e-04 |
| RHO GTPases activate CIT | 18 | 1.61e-03 | 5.48e-03 | 0.455 | 0.109000 | 0.4420 | 4.24e-01 | 1.16e-03 |
| Suppression of phagosomal maturation | 12 | 7.24e-03 | 1.95e-02 | 0.517 | 0.161000 | 0.4920 | 3.35e-01 | 3.19e-03 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 83 | 2.23e-08 | 3.13e-07 | 0.237 | 0.134000 | -0.1960 | 3.54e-02 | 2.07e-03 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 4.83e-03 | 1.39e-02 | 0.554 | 0.191000 | 0.5190 | 2.52e-01 | 1.83e-03 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 16 | 1.06e-02 | 2.69e-02 | 0.367 | 0.038000 | 0.3650 | 7.93e-01 | 1.14e-02 |
| rRNA processing in the mitochondrion | 29 | 5.07e-04 | 2.03e-03 | 0.336 | -0.336000 | -0.0104 | 1.75e-03 | 9.22e-01 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 25 | 3.17e-05 | 1.76e-04 | 0.528 | 0.175000 | 0.4980 | 1.31e-01 | 1.60e-05 |
| BBSome-mediated cargo-targeting to cilium | 22 | 8.02e-03 | 2.12e-02 | 0.272 | 0.050800 | -0.2680 | 6.80e-01 | 2.98e-02 |
| Regulated proteolysis of p75NTR | 11 | 8.94e-03 | 2.31e-02 | 0.547 | 0.194000 | 0.5120 | 2.66e-01 | 3.27e-03 |
| Sema4D in semaphorin signaling | 22 | 3.76e-04 | 1.56e-03 | 0.475 | 0.138000 | 0.4550 | 2.64e-01 | 2.23e-04 |
| Post-chaperonin tubulin folding pathway | 19 | 5.49e-03 | 1.55e-02 | 0.367 | 0.047600 | 0.3640 | 7.19e-01 | 5.99e-03 |
| Constitutive Signaling by AKT1 E17K in Cancer | 26 | 4.24e-03 | 1.25e-02 | 0.265 | -0.053900 | 0.2590 | 6.34e-01 | 2.23e-02 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 11 | 1.86e-02 | 4.11e-02 | 0.485 | 0.149000 | 0.4610 | 3.92e-01 | 8.10e-03 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.low.CRP | s.high.CRP | p.low.CRP | p.high.CRP |
|---|---|---|---|---|---|---|---|---|
| CD22 mediated BCR regulation | 58 | 1.55e-15 | 9.58e-14 | 0.4000 | 0.197000 | -0.3480 | 9.56e-03 | 4.59e-06 |
| VLDLR internalisation and degradation | 11 | 1.28e-04 | 6.00e-04 | 0.6420 | 0.095400 | 0.6350 | 5.84e-01 | 2.66e-04 |
| Scavenging of heme from plasma | 70 | 2.16e-17 | 1.73e-15 | 0.3760 | 0.250000 | -0.2800 | 2.92e-04 | 5.05e-05 |
| Classical antibody-mediated complement activation | 68 | 7.31e-15 | 3.56e-13 | 0.3660 | 0.161000 | -0.3280 | 2.16e-02 | 2.87e-06 |
| Creation of C4 and C2 activators | 70 | 4.10e-15 | 2.43e-13 | 0.3590 | 0.174000 | -0.3140 | 1.18e-02 | 5.41e-06 |
| Pre-NOTCH Processing in Golgi | 18 | 2.80e-05 | 1.61e-04 | 0.5220 | 0.047900 | 0.5190 | 7.25e-01 | 1.36e-04 |
| tRNA processing in the mitochondrion | 32 | 1.76e-07 | 2.05e-06 | 0.4100 | -0.405000 | 0.0665 | 7.36e-05 | 5.15e-01 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 73 | 4.31e-14 | 1.78e-12 | 0.3290 | 0.230000 | -0.2360 | 6.84e-04 | 4.98e-04 |
| Nucleobase biosynthesis | 13 | 1.93e-03 | 6.45e-03 | 0.4180 | 0.047300 | -0.4160 | 7.68e-01 | 9.46e-03 |
| FCGR activation | 75 | 3.32e-14 | 1.43e-12 | 0.3420 | 0.143000 | -0.3110 | 3.22e-02 | 3.24e-06 |
| Initial triggering of complement | 77 | 3.37e-14 | 1.43e-12 | 0.3320 | 0.158000 | -0.2920 | 1.65e-02 | 9.18e-06 |
| Purine ribonucleoside monophosphate biosynthesis | 10 | 1.67e-02 | 3.81e-02 | 0.3510 | 0.113000 | -0.3320 | 5.35e-01 | 6.88e-02 |
| N-Glycan antennae elongation | 13 | 4.13e-03 | 1.22e-02 | 0.3830 | -0.378000 | 0.0609 | 1.82e-02 | 7.04e-01 |
| Metabolism of amine-derived hormones | 10 | 1.80e-02 | 4.01e-02 | 0.3800 | 0.046600 | -0.3780 | 7.99e-01 | 3.87e-02 |
| Binding and Uptake of Ligands by Scavenger Receptors | 91 | 9.23e-15 | 4.34e-13 | 0.3140 | 0.280000 | -0.1420 | 3.95e-06 | 1.90e-02 |
| Pausing and recovery of Tat-mediated HIV elongation | 30 | 2.00e-05 | 1.19e-04 | 0.3250 | -0.118000 | 0.3030 | 2.64e-01 | 4.10e-03 |
| Tat-mediated HIV elongation arrest and recovery | 30 | 2.00e-05 | 1.19e-04 | 0.3250 | -0.118000 | 0.3030 | 2.64e-01 | 4.10e-03 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 11 | 1.20e-02 | 2.94e-02 | 0.3980 | 0.016700 | -0.3980 | 9.24e-01 | 2.23e-02 |
| Regulation of TP53 Activity through Acetylation | 29 | 8.63e-06 | 5.77e-05 | 0.4000 | -0.400000 | 0.0133 | 1.92e-04 | 9.01e-01 |
| ERKs are inactivated | 13 | 1.09e-03 | 3.94e-03 | 0.5450 | 0.121000 | 0.5310 | 4.49e-01 | 9.15e-04 |
| Endosomal/Vacuolar pathway | 12 | 1.28e-02 | 3.11e-02 | 0.3650 | -0.363000 | 0.0386 | 2.95e-02 | 8.17e-01 |
| HIV elongation arrest and recovery | 32 | 2.99e-05 | 1.68e-04 | 0.3080 | -0.115000 | 0.2850 | 2.59e-01 | 5.25e-03 |
| Pausing and recovery of HIV elongation | 32 | 2.99e-05 | 1.68e-04 | 0.3080 | -0.115000 | 0.2850 | 2.59e-01 | 5.25e-03 |
| Role of phospholipids in phagocytosis | 87 | 3.18e-12 | 9.22e-11 | 0.2900 | 0.135000 | -0.2570 | 3.01e-02 | 3.51e-05 |
| WNT5A-dependent internalization of FZD4 | 13 | 9.68e-04 | 3.58e-03 | 0.5780 | 0.165000 | 0.5540 | 3.02e-01 | 5.46e-04 |
| Regulation of Complement cascade | 93 | 1.56e-12 | 4.61e-11 | 0.2740 | 0.203000 | -0.1850 | 7.10e-04 | 2.09e-03 |
| Complement cascade | 97 | 1.56e-12 | 4.61e-11 | 0.2690 | 0.201000 | -0.1790 | 6.33e-04 | 2.33e-03 |
| HDMs demethylate histones | 22 | 1.45e-03 | 5.03e-03 | 0.3250 | -0.044400 | 0.3220 | 7.19e-01 | 8.96e-03 |
| SUMOylation of immune response proteins | 11 | 7.14e-03 | 1.94e-02 | 0.5220 | 0.139000 | 0.5030 | 4.25e-01 | 3.88e-03 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 23 | 2.22e-03 | 7.10e-03 | 0.2840 | -0.088300 | 0.2700 | 4.64e-01 | 2.48e-02 |
| Retrograde neurotrophin signalling | 12 | 5.84e-04 | 2.31e-03 | 0.6820 | 0.269000 | 0.6260 | 1.06e-01 | 1.73e-04 |
| FCERI mediated Ca+2 mobilization | 88 | 2.55e-10 | 5.18e-09 | 0.2600 | 0.136000 | -0.2210 | 2.78e-02 | 3.34e-04 |
| FCERI mediated MAPK activation | 89 | 2.70e-10 | 5.39e-09 | 0.2580 | 0.221000 | -0.1330 | 3.06e-04 | 3.02e-02 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 1.02e-04 | 4.96e-04 | 0.8410 | 0.395000 | 0.7420 | 2.32e-02 | 2.01e-05 |
| GPVI-mediated activation cascade | 31 | 3.29e-05 | 1.79e-04 | 0.4120 | 0.063200 | 0.4070 | 5.42e-01 | 8.70e-05 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | 15 | 1.58e-02 | 3.65e-02 | 0.3380 | -0.000913 | 0.3380 | 9.95e-01 | 2.34e-02 |
| AKT phosphorylates targets in the cytosol | 14 | 2.16e-03 | 7.02e-03 | 0.5410 | 0.176000 | 0.5110 | 2.54e-01 | 9.21e-04 |
| RHO GTPases activate CIT | 18 | 1.61e-03 | 5.48e-03 | 0.4550 | 0.109000 | 0.4420 | 4.24e-01 | 1.16e-03 |
| Suppression of phagosomal maturation | 12 | 7.24e-03 | 1.95e-02 | 0.5170 | 0.161000 | 0.4920 | 3.35e-01 | 3.19e-03 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 83 | 2.23e-08 | 3.13e-07 | 0.2370 | 0.134000 | -0.1960 | 3.54e-02 | 2.07e-03 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 4.83e-03 | 1.39e-02 | 0.5540 | 0.191000 | 0.5190 | 2.52e-01 | 1.83e-03 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 16 | 1.06e-02 | 2.69e-02 | 0.3670 | 0.038000 | 0.3650 | 7.93e-01 | 1.14e-02 |
| rRNA processing in the mitochondrion | 29 | 5.07e-04 | 2.03e-03 | 0.3360 | -0.336000 | -0.0104 | 1.75e-03 | 9.22e-01 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 25 | 3.17e-05 | 1.76e-04 | 0.5280 | 0.175000 | 0.4980 | 1.31e-01 | 1.60e-05 |
| BBSome-mediated cargo-targeting to cilium | 22 | 8.02e-03 | 2.12e-02 | 0.2720 | 0.050800 | -0.2680 | 6.80e-01 | 2.98e-02 |
| Regulated proteolysis of p75NTR | 11 | 8.94e-03 | 2.31e-02 | 0.5470 | 0.194000 | 0.5120 | 2.66e-01 | 3.27e-03 |
| Sema4D in semaphorin signaling | 22 | 3.76e-04 | 1.56e-03 | 0.4750 | 0.138000 | 0.4550 | 2.64e-01 | 2.23e-04 |
| Post-chaperonin tubulin folding pathway | 19 | 5.49e-03 | 1.55e-02 | 0.3670 | 0.047600 | 0.3640 | 7.19e-01 | 5.99e-03 |
| Constitutive Signaling by AKT1 E17K in Cancer | 26 | 4.24e-03 | 1.25e-02 | 0.2650 | -0.053900 | 0.2590 | 6.34e-01 | 2.23e-02 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 11 | 1.86e-02 | 4.11e-02 | 0.4850 | 0.149000 | 0.4610 | 3.92e-01 | 8.10e-03 |
| FCGR3A-mediated IL10 synthesis | 98 | 8.66e-09 | 1.33e-07 | 0.2240 | 0.124000 | -0.1870 | 3.37e-02 | 1.40e-03 |
| Platelet sensitization by LDL | 16 | 1.20e-04 | 5.68e-04 | 0.6750 | 0.298000 | 0.6060 | 3.92e-02 | 2.69e-05 |
| Gap junction trafficking | 13 | 8.55e-04 | 3.26e-03 | 0.6600 | 0.288000 | 0.5940 | 7.20e-02 | 2.08e-04 |
| Recycling pathway of L1 | 26 | 6.08e-05 | 3.13e-04 | 0.5070 | 0.174000 | 0.4760 | 1.24e-01 | 2.65e-05 |
| N-glycan antennae elongation in the medial/trans-Golgi | 21 | 2.00e-02 | 4.37e-02 | 0.2380 | -0.227000 | 0.0733 | 7.20e-02 | 5.61e-01 |
| TNFs bind their physiological receptors | 25 | 1.15e-02 | 2.85e-02 | 0.2240 | 0.097000 | -0.2020 | 4.01e-01 | 8.11e-02 |
| Signaling by WNT in cancer | 30 | 5.11e-03 | 1.46e-02 | 0.2220 | -0.095900 | 0.2000 | 3.63e-01 | 5.76e-02 |
| Misspliced GSK3beta mutants stabilize beta-catenin | 15 | 1.74e-02 | 3.92e-02 | 0.3900 | 0.086400 | 0.3810 | 5.62e-01 | 1.07e-02 |
| S33 mutants of beta-catenin aren't phosphorylated | 15 | 1.74e-02 | 3.92e-02 | 0.3900 | 0.086400 | 0.3810 | 5.62e-01 | 1.07e-02 |
| S37 mutants of beta-catenin aren't phosphorylated | 15 | 1.74e-02 | 3.92e-02 | 0.3900 | 0.086400 | 0.3810 | 5.62e-01 | 1.07e-02 |
| S45 mutants of beta-catenin aren't phosphorylated | 15 | 1.74e-02 | 3.92e-02 | 0.3900 | 0.086400 | 0.3810 | 5.62e-01 | 1.07e-02 |
| T41 mutants of beta-catenin aren't phosphorylated | 15 | 1.74e-02 | 3.92e-02 | 0.3900 | 0.086400 | 0.3810 | 5.62e-01 | 1.07e-02 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | 15 | 1.74e-02 | 3.92e-02 | 0.3900 | 0.086400 | 0.3810 | 5.62e-01 | 1.07e-02 |
| TBC/RABGAPs | 45 | 5.00e-06 | 3.55e-05 | 0.3970 | 0.095000 | 0.3850 | 2.70e-01 | 7.65e-06 |
| Initiation of Nuclear Envelope (NE) Reformation | 19 | 1.31e-02 | 3.18e-02 | 0.3330 | 0.040000 | 0.3310 | 7.63e-01 | 1.26e-02 |
| Translation of structural proteins | 28 | 8.61e-03 | 2.26e-02 | 0.2300 | -0.065600 | 0.2200 | 5.48e-01 | 4.40e-02 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 13 | 9.94e-04 | 3.65e-03 | 0.6690 | 0.312000 | 0.5920 | 5.14e-02 | 2.19e-04 |
| EGFR downregulation | 26 | 1.85e-05 | 1.12e-04 | 0.5720 | 0.240000 | 0.5190 | 3.39e-02 | 4.58e-06 |
| RHO GTPases Activate ROCKs | 18 | 8.93e-05 | 4.43e-04 | 0.6630 | 0.313000 | 0.5850 | 2.13e-02 | 1.74e-05 |
| Sema4D induced cell migration and growth-cone collapse | 19 | 2.65e-03 | 8.20e-03 | 0.4680 | 0.167000 | 0.4380 | 2.08e-01 | 9.58e-04 |
| Citric acid cycle (TCA cycle) | 22 | 5.38e-03 | 1.53e-02 | 0.3740 | 0.093500 | 0.3630 | 4.48e-01 | 3.24e-03 |
| RHO GTPases activate PAKs | 20 | 1.98e-04 | 8.89e-04 | 0.5870 | 0.260000 | 0.5270 | 4.44e-02 | 4.49e-05 |
| Mucopolysaccharidoses | 11 | 6.64e-03 | 1.82e-02 | 0.6150 | 0.282000 | 0.5470 | 1.06e-01 | 1.68e-03 |
| Beta-catenin phosphorylation cascade | 17 | 4.40e-03 | 1.28e-02 | 0.4820 | 0.182000 | 0.4460 | 1.94e-01 | 1.44e-03 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | 10 | 3.92e-03 | 1.17e-02 | 0.6990 | 0.346000 | 0.6070 | 5.78e-02 | 8.88e-04 |
| Uptake and function of anthrax toxins | 10 | 1.57e-04 | 7.16e-04 | 0.9150 | 0.505000 | 0.7630 | 5.68e-03 | 2.93e-05 |
| UCH proteinases | 86 | 8.05e-08 | 9.80e-07 | 0.3190 | 0.059300 | 0.3140 | 3.42e-01 | 4.96e-07 |
| XBP1(S) activates chaperone genes | 47 | 5.47e-05 | 2.87e-04 | 0.3530 | 0.090400 | 0.3410 | 2.84e-01 | 5.16e-05 |
| Advanced glycosylation endproduct receptor signaling | 12 | 2.24e-04 | 9.88e-04 | 0.8090 | 0.432000 | 0.6830 | 9.49e-03 | 4.15e-05 |
| Spry regulation of FGF signaling | 16 | 1.29e-03 | 4.55e-03 | 0.5920 | 0.276000 | 0.5230 | 5.63e-02 | 2.88e-04 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | 29 | 1.38e-03 | 4.85e-03 | 0.3830 | 0.118000 | 0.3650 | 2.72e-01 | 6.70e-04 |
| IRE1alpha activates chaperones | 49 | 5.77e-05 | 3.00e-04 | 0.3430 | 0.085100 | 0.3320 | 3.02e-01 | 5.79e-05 |
| Assembly Of The HIV Virion | 15 | 7.55e-03 | 2.02e-02 | 0.5050 | 0.212000 | 0.4580 | 1.54e-01 | 2.14e-03 |
| RORA activates gene expression | 18 | 1.54e-02 | 3.57e-02 | 0.3970 | 0.135000 | 0.3740 | 3.23e-01 | 6.01e-03 |
| ERK/MAPK targets | 22 | 1.23e-03 | 4.36e-03 | 0.4880 | 0.205000 | 0.4430 | 9.63e-02 | 3.25e-04 |
| Metabolism of Angiotensinogen to Angiotensins | 11 | 8.86e-03 | 2.29e-02 | 0.6120 | 0.534000 | 0.3000 | 2.16e-03 | 8.52e-02 |
| PKA activation in glucagon signalling | 14 | 2.06e-02 | 4.47e-02 | 0.4600 | 0.186000 | 0.4200 | 2.28e-01 | 6.47e-03 |
| Activated NOTCH1 Transmits Signal to the Nucleus | 27 | 6.24e-03 | 1.71e-02 | 0.3400 | 0.093900 | 0.3270 | 3.98e-01 | 3.26e-03 |
| SARS-CoV-1 Infection | 47 | 3.48e-04 | 1.47e-03 | 0.3100 | 0.069200 | 0.3020 | 4.12e-01 | 3.38e-04 |
| Processive synthesis on the lagging strand | 15 | 1.12e-02 | 2.79e-02 | 0.4860 | -0.207000 | -0.4400 | 1.65e-01 | 3.20e-03 |
| Membrane binding and targetting of GAG proteins | 13 | 1.40e-02 | 3.34e-02 | 0.5170 | 0.231000 | 0.4630 | 1.50e-01 | 3.85e-03 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 13 | 1.40e-02 | 3.34e-02 | 0.5170 | 0.231000 | 0.4630 | 1.50e-01 | 3.85e-03 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 37 | 1.07e-02 | 2.71e-02 | 0.2160 | -0.016800 | 0.2150 | 8.60e-01 | 2.37e-02 |
| Budding and maturation of HIV virion | 26 | 4.82e-06 | 3.46e-05 | 0.6510 | 0.331000 | 0.5600 | 3.46e-03 | 7.57e-07 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 35 | 2.44e-04 | 1.07e-03 | 0.4160 | 0.157000 | 0.3850 | 1.09e-01 | 8.04e-05 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 25 | 2.22e-02 | 4.79e-02 | 0.2850 | 0.052000 | 0.2800 | 6.53e-01 | 1.54e-02 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 11 | 1.48e-02 | 3.47e-02 | 0.5740 | 0.276000 | 0.5040 | 1.13e-01 | 3.83e-03 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 16 | 1.66e-02 | 3.78e-02 | 0.4400 | 0.176000 | 0.4030 | 2.24e-01 | 5.24e-03 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 32 | 1.08e-02 | 2.71e-02 | 0.2650 | 0.035100 | 0.2620 | 7.31e-01 | 1.02e-02 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | 42 | 8.76e-03 | 2.27e-02 | 0.1980 | -0.031200 | 0.1960 | 7.27e-01 | 2.81e-02 |
| HIV Transcription Elongation | 42 | 8.76e-03 | 2.27e-02 | 0.1980 | -0.031200 | 0.1960 | 7.27e-01 | 2.81e-02 |
| Tat-mediated elongation of the HIV-1 transcript | 42 | 8.76e-03 | 2.27e-02 | 0.1980 | -0.031200 | 0.1960 | 7.27e-01 | 2.81e-02 |
| Gap junction trafficking and regulation | 15 | 1.28e-02 | 3.11e-02 | 0.4800 | 0.207000 | 0.4340 | 1.65e-01 | 3.64e-03 |
| Formation of ATP by chemiosmotic coupling | 18 | 1.89e-03 | 6.36e-03 | 0.5430 | 0.255000 | 0.4790 | 6.12e-02 | 4.28e-04 |
| Inhibition of DNA recombination at telomere | 35 | 1.01e-04 | 4.91e-04 | 0.4510 | 0.186000 | 0.4110 | 5.63e-02 | 2.63e-05 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | 23 | 1.62e-02 | 3.71e-02 | 0.3380 | 0.099800 | 0.3230 | 4.07e-01 | 7.41e-03 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 22 | 2.11e-03 | 6.95e-03 | 0.4720 | 0.204000 | 0.4260 | 9.81e-02 | 5.43e-04 |
| SUMOylation of intracellular receptors | 25 | 2.26e-02 | 4.86e-02 | 0.2910 | 0.062300 | 0.2840 | 5.90e-01 | 1.39e-02 |
| Formation of HIV elongation complex in the absence of HIV Tat | 44 | 9.38e-03 | 2.41e-02 | 0.1910 | -0.033200 | 0.1880 | 7.03e-01 | 3.11e-02 |
| tRNA modification in the nucleus and cytosol | 43 | 1.42e-03 | 4.92e-03 | 0.2940 | -0.066000 | -0.2870 | 4.54e-01 | 1.14e-03 |
| Transport of the SLBP Dependant Mature mRNA | 36 | 1.16e-02 | 2.87e-02 | 0.2360 | -0.014800 | -0.2350 | 8.78e-01 | 1.45e-02 |
| HDACs deacetylate histones | 47 | 2.10e-06 | 1.78e-05 | 0.4730 | 0.206000 | 0.4250 | 1.45e-02 | 4.54e-07 |
| Metabolism of non-coding RNA | 53 | 1.19e-03 | 4.23e-03 | 0.2460 | -0.025600 | -0.2450 | 7.48e-01 | 2.07e-03 |
| snRNP Assembly | 53 | 1.19e-03 | 4.23e-03 | 0.2460 | -0.025600 | -0.2450 | 7.48e-01 | 2.07e-03 |
| DARPP-32 events | 22 | 1.24e-03 | 4.38e-03 | 0.5010 | 0.228000 | 0.4470 | 6.45e-02 | 2.87e-04 |
| PCP/CE pathway | 86 | 1.48e-08 | 2.16e-07 | 0.3890 | 0.145000 | 0.3610 | 2.01e-02 | 6.83e-09 |
| Transport of the SLBP independent Mature mRNA | 35 | 1.02e-02 | 2.59e-02 | 0.2580 | -0.038800 | -0.2550 | 6.91e-01 | 9.00e-03 |
| Glycosphingolipid metabolism | 36 | 2.13e-03 | 6.95e-03 | 0.3310 | 0.099600 | 0.3160 | 3.01e-01 | 1.04e-03 |
| NR1H2 and NR1H3-mediated signaling | 38 | 6.03e-03 | 1.68e-02 | 0.2690 | 0.050800 | 0.2640 | 5.88e-01 | 4.84e-03 |
| Gluconeogenesis | 28 | 8.56e-03 | 2.25e-02 | 0.3330 | 0.104000 | 0.3170 | 3.41e-01 | 3.74e-03 |
| Transcriptional regulation of white adipocyte differentiation | 77 | 1.97e-06 | 1.71e-05 | 0.3350 | 0.105000 | 0.3180 | 1.10e-01 | 1.41e-06 |
| Complex I biogenesis | 55 | 1.14e-04 | 5.43e-04 | 0.3280 | 0.102000 | 0.3120 | 1.91e-01 | 6.26e-05 |
| Notch-HLH transcription pathway | 28 | 2.62e-04 | 1.14e-03 | 0.4970 | 0.231000 | 0.4400 | 3.44e-02 | 5.46e-05 |
| GAB1 signalosome | 14 | 7.36e-03 | 1.97e-02 | 0.5550 | 0.273000 | 0.4830 | 7.65e-02 | 1.76e-03 |
| SARS-CoV-2 Infection | 63 | 2.45e-05 | 1.42e-04 | 0.3360 | 0.110000 | 0.3180 | 1.32e-01 | 1.30e-05 |
| NEP/NS2 Interacts with the Cellular Export Machinery | 32 | 7.05e-03 | 1.92e-02 | 0.3130 | -0.092100 | -0.2990 | 3.67e-01 | 3.37e-03 |
| Glycosaminoglycan metabolism | 92 | 1.53e-05 | 9.32e-05 | 0.2480 | 0.038200 | 0.2450 | 5.26e-01 | 4.75e-05 |
| Nuclear Events (kinase and transcription factor activation) | 53 | 2.93e-05 | 1.66e-04 | 0.3810 | 0.146000 | 0.3520 | 6.56e-02 | 9.45e-06 |
| TGF-beta receptor signaling activates SMADs | 32 | 6.08e-03 | 1.69e-02 | 0.3250 | 0.104000 | 0.3080 | 3.08e-01 | 2.58e-03 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 29 | 2.76e-06 | 2.20e-05 | 0.6400 | 0.339000 | 0.5430 | 1.56e-03 | 4.21e-07 |
| Signaling by Erythropoietin | 24 | 1.78e-03 | 6.04e-03 | 0.4680 | 0.213000 | 0.4160 | 7.02e-02 | 4.18e-04 |
| Cellular response to hypoxia | 71 | 1.53e-09 | 2.64e-08 | 0.4930 | 0.233000 | 0.4350 | 6.98e-04 | 2.31e-10 |
| Regulation of actin dynamics for phagocytic cup formation | 122 | 7.10e-08 | 8.80e-07 | 0.2840 | 0.275000 | 0.0726 | 1.59e-07 | 1.66e-01 |
| FCGR3A-mediated phagocytosis | 120 | 5.89e-07 | 5.95e-06 | 0.2550 | 0.250000 | 0.0490 | 2.26e-06 | 3.54e-01 |
| Leishmania phagocytosis | 120 | 5.89e-07 | 5.95e-06 | 0.2550 | 0.250000 | 0.0490 | 2.26e-06 | 3.54e-01 |
| Parasite infection | 120 | 5.89e-07 | 5.95e-06 | 0.2550 | 0.250000 | 0.0490 | 2.26e-06 | 3.54e-01 |
| Formation of RNA Pol II elongation complex | 57 | 2.23e-03 | 7.10e-03 | 0.2260 | 0.024200 | 0.2250 | 7.52e-01 | 3.30e-03 |
| RNA Polymerase II Transcription Elongation | 57 | 2.23e-03 | 7.10e-03 | 0.2260 | 0.024200 | 0.2250 | 7.52e-01 | 3.30e-03 |
| Export of Viral Ribonucleoproteins from Nucleus | 33 | 1.43e-02 | 3.39e-02 | 0.2730 | -0.064400 | -0.2650 | 5.22e-01 | 8.40e-03 |
| Calnexin/calreticulin cycle | 26 | 1.01e-03 | 3.68e-03 | 0.4720 | 0.219000 | 0.4180 | 5.33e-02 | 2.25e-04 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 32 | 4.24e-03 | 1.25e-02 | 0.3480 | 0.126000 | 0.3240 | 2.18e-01 | 1.49e-03 |
| Regulation of PTEN stability and activity | 66 | 2.07e-07 | 2.37e-06 | 0.4350 | 0.192000 | 0.3900 | 7.10e-03 | 4.23e-08 |
| Lagging Strand Synthesis | 20 | 2.17e-03 | 7.03e-03 | 0.5180 | -0.254000 | -0.4510 | 4.97e-02 | 4.74e-04 |
| Negative regulation of MAPK pathway | 42 | 8.70e-03 | 2.27e-02 | 0.2460 | 0.045600 | 0.2420 | 6.09e-01 | 6.75e-03 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 22 | 1.02e-04 | 4.96e-04 | 0.6240 | 0.333000 | 0.5280 | 6.91e-03 | 1.82e-05 |
| Synthesis of PIPs at the plasma membrane | 52 | 4.81e-03 | 1.39e-02 | 0.2240 | 0.027800 | 0.2220 | 7.29e-01 | 5.54e-03 |
| RAF activation | 32 | 3.57e-04 | 1.49e-03 | 0.4550 | 0.210000 | 0.4040 | 4.01e-02 | 7.66e-05 |
| PPARA activates gene expression | 104 | 3.49e-09 | 5.66e-08 | 0.3770 | 0.152000 | 0.3460 | 7.52e-03 | 1.13e-09 |
| Regulation of lipid metabolism by PPARalpha | 106 | 8.95e-09 | 1.35e-07 | 0.3590 | 0.138000 | 0.3320 | 1.42e-02 | 3.61e-09 |
| Signaling by NOTCH3 | 42 | 2.36e-03 | 7.39e-03 | 0.3090 | 0.099300 | 0.2930 | 2.66e-01 | 1.03e-03 |
| ER-Phagosome pathway | 82 | 5.95e-10 | 1.05e-08 | 0.4690 | 0.221000 | 0.4140 | 5.53e-04 | 9.00e-11 |
| Diseases of carbohydrate metabolism | 29 | 9.92e-04 | 3.65e-03 | 0.4440 | 0.203000 | 0.3960 | 5.89e-02 | 2.26e-04 |
| Cargo recognition for clathrin-mediated endocytosis | 88 | 4.01e-09 | 6.43e-08 | 0.4220 | 0.187000 | 0.3790 | 2.47e-03 | 8.01e-10 |
| RHO GTPases activate PKNs | 47 | 4.15e-09 | 6.57e-08 | 0.6200 | 0.332000 | 0.5230 | 8.24e-05 | 5.25e-10 |
| Clathrin-mediated endocytosis | 125 | 8.48e-14 | 2.96e-12 | 0.4500 | 0.208000 | 0.3990 | 6.07e-05 | 1.32e-14 |
| Activation of HOX genes during differentiation | 69 | 3.21e-04 | 1.37e-03 | 0.2600 | 0.062300 | 0.2530 | 3.71e-01 | 2.80e-04 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 69 | 3.21e-04 | 1.37e-03 | 0.2600 | 0.062300 | 0.2530 | 3.71e-01 | 2.80e-04 |
| Signaling by EGFR | 45 | 1.13e-04 | 5.43e-04 | 0.4000 | 0.171000 | 0.3610 | 4.71e-02 | 2.73e-05 |
| Packaging Of Telomere Ends | 20 | 8.41e-04 | 3.23e-03 | 0.5690 | 0.297000 | 0.4860 | 2.16e-02 | 1.68e-04 |
| Glycogen breakdown (glycogenolysis) | 13 | 1.78e-02 | 3.97e-02 | 0.5260 | 0.265000 | 0.4540 | 9.75e-02 | 4.56e-03 |
| RHO GTPases activate IQGAPs | 11 | 1.38e-02 | 3.31e-02 | 0.6020 | 0.321000 | 0.5090 | 6.52e-02 | 3.43e-03 |
| Vpr-mediated nuclear import of PICs | 34 | 1.09e-02 | 2.74e-02 | 0.2950 | -0.092100 | -0.2800 | 3.53e-01 | 4.72e-03 |
| FCERI mediated NF-kB activation | 136 | 2.60e-06 | 2.11e-05 | 0.2150 | 0.213000 | 0.0258 | 1.74e-05 | 6.04e-01 |
| activated TAK1 mediates p38 MAPK activation | 19 | 9.67e-04 | 3.58e-03 | 0.5810 | 0.306000 | 0.4940 | 2.09e-02 | 1.95e-04 |
| CD28 dependent PI3K/Akt signaling | 22 | 4.85e-03 | 1.39e-02 | 0.4540 | -0.400000 | -0.2140 | 1.16e-03 | 8.26e-02 |
| Rab regulation of trafficking | 120 | 7.63e-10 | 1.33e-08 | 0.3660 | 0.148000 | 0.3340 | 4.99e-03 | 2.43e-10 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 64 | 9.91e-08 | 1.18e-06 | 0.4660 | 0.223000 | 0.4090 | 2.03e-03 | 1.54e-08 |
| Interferon alpha/beta signaling | 57 | 4.21e-06 | 3.12e-05 | 0.4230 | -0.377000 | -0.1920 | 8.21e-07 | 1.23e-02 |
| Asymmetric localization of PCP proteins | 60 | 6.21e-05 | 3.18e-04 | 0.3450 | 0.133000 | 0.3190 | 7.40e-02 | 1.95e-05 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 55 | 1.46e-04 | 6.72e-04 | 0.3440 | 0.133000 | 0.3180 | 8.82e-02 | 4.55e-05 |
| rRNA modification in the nucleus and cytosol | 59 | 5.77e-06 | 4.03e-05 | 0.4070 | -0.180000 | -0.3650 | 1.65e-02 | 1.21e-06 |
| Inflammasomes | 20 | 1.93e-04 | 8.69e-04 | 0.6380 | 0.533000 | 0.3490 | 3.62e-05 | 6.81e-03 |
| Regulation of IFNG signaling | 14 | 1.74e-02 | 3.92e-02 | 0.5080 | 0.255000 | 0.4390 | 9.85e-02 | 4.47e-03 |
| VxPx cargo-targeting to cilium | 19 | 1.99e-02 | 4.36e-02 | 0.4100 | 0.184000 | 0.3670 | 1.66e-01 | 5.62e-03 |
| Cell surface interactions at the vascular wall | 172 | 5.16e-08 | 6.64e-07 | 0.2290 | 0.225000 | 0.0418 | 3.63e-07 | 3.44e-01 |
| Regulation of RUNX3 expression and activity | 55 | 2.63e-05 | 1.52e-04 | 0.3920 | 0.170000 | 0.3530 | 2.90e-02 | 5.93e-06 |
| Interactions of Rev with host cellular proteins | 37 | 4.06e-03 | 1.21e-02 | 0.3270 | -0.121000 | -0.3040 | 2.01e-01 | 1.37e-03 |
| Senescence-Associated Secretory Phenotype (SASP) | 66 | 4.21e-06 | 3.12e-05 | 0.3860 | 0.166000 | 0.3490 | 1.96e-02 | 9.59e-07 |
| Defective CFTR causes cystic fibrosis | 58 | 2.79e-07 | 3.15e-06 | 0.4780 | 0.235000 | 0.4160 | 2.00e-03 | 4.20e-08 |
| Activation of gene expression by SREBF (SREBP) | 42 | 2.13e-03 | 6.96e-03 | 0.3250 | 0.120000 | 0.3020 | 1.77e-01 | 7.19e-04 |
| Detoxification of Reactive Oxygen Species | 31 | 5.24e-08 | 6.67e-07 | 0.7280 | 0.417000 | 0.5970 | 5.93e-05 | 8.44e-09 |
| Antigen processing-Cross presentation | 97 | 7.58e-13 | 2.40e-11 | 0.5090 | 0.258000 | 0.4380 | 1.08e-05 | 8.20e-14 |
| COPI-mediated anterograde transport | 78 | 2.53e-10 | 5.18e-09 | 0.5040 | 0.255000 | 0.4350 | 9.81e-05 | 3.06e-11 |
| Degradation of DVL | 54 | 2.36e-06 | 1.95e-05 | 0.4550 | 0.219000 | 0.3990 | 5.32e-03 | 3.92e-07 |
| Glycogen metabolism | 23 | 5.14e-03 | 1.46e-02 | 0.4420 | 0.210000 | 0.3890 | 8.13e-02 | 1.23e-03 |
| Signal transduction by L1 | 20 | 5.68e-04 | 2.26e-03 | 0.5930 | 0.320000 | 0.4990 | 1.31e-02 | 1.12e-04 |
| PI Metabolism | 79 | 1.92e-03 | 6.42e-03 | 0.1860 | 0.007670 | 0.1860 | 9.06e-01 | 4.24e-03 |
| Cleavage of the damaged purine | 24 | 3.69e-03 | 1.11e-02 | 0.4480 | 0.215000 | 0.3930 | 6.81e-02 | 8.54e-04 |
| Depurination | 24 | 3.69e-03 | 1.11e-02 | 0.4480 | 0.215000 | 0.3930 | 6.81e-02 | 8.54e-04 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 24 | 3.69e-03 | 1.11e-02 | 0.4480 | 0.215000 | 0.3930 | 6.81e-02 | 8.54e-04 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 31 | 1.69e-02 | 3.84e-02 | 0.3020 | -0.105000 | -0.2830 | 3.10e-01 | 6.34e-03 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | 31 | 1.69e-02 | 3.84e-02 | 0.3020 | -0.105000 | -0.2830 | 3.10e-01 | 6.34e-03 |
| Rev-mediated nuclear export of HIV RNA | 35 | 5.52e-03 | 1.55e-02 | 0.3320 | -0.129000 | -0.3060 | 1.87e-01 | 1.74e-03 |
| Transport to the Golgi and subsequent modification | 155 | 7.98e-14 | 2.86e-12 | 0.4010 | 0.181000 | 0.3580 | 9.86e-05 | 1.43e-14 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | 27 | 1.43e-03 | 4.97e-03 | 0.4600 | 0.226000 | 0.4010 | 4.24e-02 | 3.06e-04 |
| TP53 Regulates Transcription of DNA Repair Genes | 61 | 2.11e-02 | 4.58e-02 | 0.1430 | -0.139000 | 0.0344 | 6.11e-02 | 6.43e-01 |
| Chromatin modifying enzymes | 217 | 1.75e-06 | 1.54e-05 | 0.1370 | -0.041900 | 0.1310 | 2.87e-01 | 9.16e-04 |
| Chromatin organization | 217 | 1.75e-06 | 1.54e-05 | 0.1370 | -0.041900 | 0.1310 | 2.87e-01 | 9.16e-04 |
| G beta:gamma signalling through PI3Kgamma | 22 | 2.28e-02 | 4.89e-02 | 0.3710 | 0.162000 | 0.3340 | 1.90e-01 | 6.69e-03 |
| Effects of PIP2 hydrolysis | 24 | 7.32e-03 | 1.97e-02 | 0.4170 | -0.368000 | -0.1960 | 1.82e-03 | 9.66e-02 |
| ER to Golgi Anterograde Transport | 129 | 4.52e-15 | 2.51e-13 | 0.4800 | 0.242000 | 0.4140 | 1.99e-06 | 4.59e-16 |
| Negative regulation of NOTCH4 signaling | 54 | 3.14e-06 | 2.48e-05 | 0.4540 | 0.224000 | 0.3950 | 4.45e-03 | 5.04e-07 |
| IRAK1 recruits IKK complex | 10 | 8.10e-03 | 2.14e-02 | 0.6870 | 0.393000 | 0.5640 | 3.12e-02 | 2.02e-03 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 10 | 8.10e-03 | 2.14e-02 | 0.6870 | 0.393000 | 0.5640 | 3.12e-02 | 2.02e-03 |
| Late endosomal microautophagy | 29 | 1.23e-04 | 5.81e-04 | 0.5370 | 0.286000 | 0.4550 | 7.78e-03 | 2.21e-05 |
| Nuclear import of Rev protein | 34 | 1.41e-02 | 3.35e-02 | 0.2990 | -0.109000 | -0.2780 | 2.71e-01 | 4.97e-03 |
| COPII-mediated vesicle transport | 65 | 2.79e-08 | 3.81e-07 | 0.4930 | 0.254000 | 0.4230 | 4.00e-04 | 3.70e-09 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 48 | 3.81e-06 | 2.92e-05 | 0.4850 | 0.248000 | 0.4170 | 2.90e-03 | 5.90e-07 |
| Phase 0 - rapid depolarisation | 22 | 1.53e-02 | 3.56e-02 | 0.4000 | -0.354000 | -0.1860 | 4.07e-03 | 1.32e-01 |
| MAP kinase activation | 63 | 3.08e-07 | 3.44e-06 | 0.4610 | 0.231000 | 0.3980 | 1.51e-03 | 4.49e-08 |
| trans-Golgi Network Vesicle Budding | 69 | 2.75e-08 | 3.79e-07 | 0.4770 | 0.243000 | 0.4100 | 4.71e-04 | 3.67e-09 |
| Signaling by NOTCH4 | 78 | 7.97e-08 | 9.79e-07 | 0.4260 | 0.206000 | 0.3730 | 1.65e-03 | 1.20e-08 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 52 | 8.37e-06 | 5.62e-05 | 0.4450 | 0.220000 | 0.3870 | 6.06e-03 | 1.39e-06 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 39 | 7.73e-04 | 2.99e-03 | 0.3920 | -0.181000 | -0.3480 | 5.05e-02 | 1.71e-04 |
| Pre-NOTCH Expression and Processing | 65 | 6.05e-07 | 6.05e-06 | 0.4400 | 0.216000 | 0.3830 | 2.55e-03 | 9.27e-08 |
| TRAF6 mediated NF-kB activation | 23 | 1.83e-02 | 4.07e-02 | 0.3780 | 0.171000 | 0.3370 | 1.55e-01 | 5.08e-03 |
| COPI-independent Golgi-to-ER retrograde traffic | 33 | 2.25e-08 | 3.13e-07 | 0.7290 | 0.426000 | 0.5920 | 2.29e-05 | 4.03e-09 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 47 | 1.71e-06 | 1.52e-05 | 0.5110 | 0.269000 | 0.4340 | 1.42e-03 | 2.56e-07 |
| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | 53 | 6.09e-07 | 6.05e-06 | 0.4980 | 0.259000 | 0.4250 | 1.09e-03 | 8.79e-08 |
| Regulation of RAS by GAPs | 66 | 1.47e-04 | 6.74e-04 | 0.3170 | 0.126000 | 0.2910 | 7.69e-02 | 4.27e-05 |
| Interleukin-17 signaling | 68 | 6.70e-07 | 6.57e-06 | 0.4270 | 0.208000 | 0.3730 | 3.00e-03 | 1.05e-07 |
| Integrin signaling | 22 | 9.18e-04 | 3.45e-03 | 0.5470 | 0.296000 | 0.4600 | 1.62e-02 | 1.86e-04 |
| Ubiquitin-dependent degradation of Cyclin D | 50 | 2.81e-05 | 1.61e-04 | 0.4280 | 0.209000 | 0.3730 | 1.05e-02 | 4.95e-06 |
| PTEN Regulation | 138 | 6.97e-08 | 8.71e-07 | 0.2950 | 0.110000 | 0.2730 | 2.55e-02 | 2.96e-08 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 6.84e-03 | 1.87e-02 | 0.4630 | -0.237000 | -0.3980 | 6.05e-02 | 1.60e-03 |
| Smooth Muscle Contraction | 30 | 2.63e-06 | 2.12e-05 | 0.6480 | 0.371000 | 0.5320 | 4.36e-04 | 4.62e-07 |
| Degradation of AXIN | 53 | 7.88e-05 | 3.95e-04 | 0.3890 | 0.183000 | 0.3430 | 2.13e-02 | 1.54e-05 |
| Base-Excision Repair, AP Site Formation | 31 | 1.43e-02 | 3.39e-02 | 0.3270 | 0.137000 | 0.2970 | 1.87e-01 | 4.23e-03 |
| Regulation of PTEN gene transcription | 59 | 3.84e-03 | 1.15e-02 | 0.2470 | 0.075400 | 0.2350 | 3.16e-01 | 1.78e-03 |
| tRNA processing in the nucleus | 59 | 1.53e-03 | 5.24e-03 | 0.2790 | -0.101000 | -0.2600 | 1.81e-01 | 5.43e-04 |
| Interleukin-1 signaling | 97 | 1.45e-14 | 6.57e-13 | 0.5610 | 0.309000 | 0.4680 | 1.50e-07 | 1.57e-15 |
| Cleavage of the damaged pyrimidine | 29 | 1.11e-02 | 2.77e-02 | 0.3560 | 0.159000 | 0.3190 | 1.38e-01 | 2.99e-03 |
| Depyrimidination | 29 | 1.11e-02 | 2.77e-02 | 0.3560 | 0.159000 | 0.3190 | 1.38e-01 | 2.99e-03 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 29 | 1.11e-02 | 2.77e-02 | 0.3560 | 0.159000 | 0.3190 | 1.38e-01 | 2.99e-03 |
| Activation of ATR in response to replication stress | 36 | 1.08e-05 | 7.09e-05 | 0.5500 | -0.301000 | -0.4600 | 1.78e-03 | 1.78e-06 |
| Degradation of beta-catenin by the destruction complex | 83 | 4.19e-06 | 3.12e-05 | 0.3480 | 0.153000 | 0.3120 | 1.59e-02 | 8.86e-07 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 53 | 2.28e-06 | 1.90e-05 | 0.4730 | 0.246000 | 0.4050 | 1.96e-03 | 3.44e-07 |
| Activation of NF-kappaB in B cells | 65 | 4.60e-06 | 3.36e-05 | 0.4050 | 0.196000 | 0.3540 | 6.28e-03 | 7.73e-07 |
| Response of Mtb to phagocytosis | 22 | 8.56e-04 | 3.26e-03 | 0.5530 | 0.304000 | 0.4620 | 1.36e-02 | 1.75e-04 |
| SCF-beta-TrCP mediated degradation of Emi1 | 53 | 6.63e-05 | 3.37e-04 | 0.3950 | 0.189000 | 0.3470 | 1.76e-02 | 1.25e-05 |
| Circadian Clock | 67 | 3.13e-03 | 9.64e-03 | 0.2300 | 0.062900 | 0.2210 | 3.73e-01 | 1.74e-03 |
| Toll Like Receptor 3 (TLR3) Cascade | 92 | 1.14e-07 | 1.35e-06 | 0.3840 | 0.181000 | 0.3390 | 2.71e-03 | 1.86e-08 |
| Hh mutants abrogate ligand secretion | 54 | 2.00e-06 | 1.73e-05 | 0.4710 | 0.245000 | 0.4030 | 1.86e-03 | 3.01e-07 |
| Vif-mediated degradation of APOBEC3G | 52 | 6.37e-06 | 4.43e-05 | 0.4570 | 0.234000 | 0.3920 | 3.47e-03 | 1.01e-06 |
| TCF dependent signaling in response to WNT | 165 | 1.56e-08 | 2.27e-07 | 0.2800 | 0.103000 | 0.2600 | 2.27e-02 | 7.76e-09 |
| ABC transporter disorders | 69 | 1.04e-06 | 9.65e-06 | 0.4190 | 0.207000 | 0.3650 | 2.93e-03 | 1.61e-07 |
| Anti-inflammatory response favouring Leishmania parasite infection | 167 | 2.96e-04 | 1.28e-03 | 0.1150 | 0.099700 | -0.0575 | 2.62e-02 | 2.00e-01 |
| Leishmania parasite growth and survival | 167 | 2.96e-04 | 1.28e-03 | 0.1150 | 0.099700 | -0.0575 | 2.62e-02 | 2.00e-01 |
| Activation of the pre-replicative complex | 32 | 1.67e-05 | 1.01e-04 | 0.5750 | -0.321000 | -0.4780 | 1.69e-03 | 2.89e-06 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 27 | 6.57e-04 | 2.57e-03 | 0.5030 | 0.269000 | 0.4260 | 1.57e-02 | 1.29e-04 |
| MyD88 cascade initiated on plasma membrane | 82 | 1.85e-10 | 3.89e-09 | 0.5060 | 0.271000 | 0.4270 | 2.15e-05 | 2.19e-11 |
| Toll Like Receptor 10 (TLR10) Cascade | 82 | 1.85e-10 | 3.89e-09 | 0.5060 | 0.271000 | 0.4270 | 2.15e-05 | 2.19e-11 |
| Toll Like Receptor 5 (TLR5) Cascade | 82 | 1.85e-10 | 3.89e-09 | 0.5060 | 0.271000 | 0.4270 | 2.15e-05 | 2.19e-11 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 49 | 9.07e-05 | 4.46e-04 | 0.4080 | 0.200000 | 0.3550 | 1.54e-02 | 1.67e-05 |
| Prolonged ERK activation events | 13 | 6.00e-03 | 1.67e-02 | 0.6210 | 0.354000 | 0.5100 | 2.70e-02 | 1.46e-03 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 92 | 5.35e-14 | 1.97e-12 | 0.5660 | 0.315000 | 0.4700 | 1.75e-07 | 6.24e-15 |
| Toll Like Receptor 2 (TLR2) Cascade | 92 | 5.35e-14 | 1.97e-12 | 0.5660 | 0.315000 | 0.4700 | 1.75e-07 | 6.24e-15 |
| Toll Like Receptor TLR1:TLR2 Cascade | 92 | 5.35e-14 | 1.97e-12 | 0.5660 | 0.315000 | 0.4700 | 1.75e-07 | 6.24e-15 |
| Toll Like Receptor TLR6:TLR2 Cascade | 92 | 5.35e-14 | 1.97e-12 | 0.5660 | 0.315000 | 0.4700 | 1.75e-07 | 6.24e-15 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 146 | 1.58e-06 | 1.43e-05 | 0.2460 | 0.233000 | 0.0784 | 1.11e-06 | 1.02e-01 |
| Membrane Trafficking | 555 | 5.94e-44 | 2.02e-41 | 0.3990 | 0.194000 | 0.3490 | 5.33e-15 | 5.80e-45 |
| Negative regulation of MET activity | 18 | 4.86e-04 | 1.96e-03 | 0.6470 | 0.374000 | 0.5280 | 6.04e-03 | 1.05e-04 |
| Respiratory electron transport | 101 | 4.86e-07 | 5.06e-06 | 0.3430 | 0.153000 | 0.3070 | 7.94e-03 | 9.65e-08 |
| SARS-CoV Infections | 140 | 4.28e-07 | 4.63e-06 | 0.2750 | 0.102000 | 0.2560 | 3.73e-02 | 1.77e-07 |
| Lysosome Vesicle Biogenesis | 32 | 1.86e-04 | 8.38e-04 | 0.5020 | 0.270000 | 0.4230 | 8.18e-03 | 3.42e-05 |
| MAP2K and MAPK activation | 34 | 5.69e-07 | 5.88e-06 | 0.6470 | 0.374000 | 0.5270 | 1.57e-04 | 1.01e-07 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 31 | 1.89e-03 | 6.36e-03 | 0.4250 | 0.215000 | 0.3670 | 3.85e-02 | 4.02e-04 |
| Degradation of GLI1 by the proteasome | 57 | 3.87e-06 | 2.95e-05 | 0.4460 | 0.230000 | 0.3820 | 2.66e-03 | 5.98e-07 |
| Signaling by VEGF | 97 | 4.56e-06 | 3.34e-05 | 0.3160 | 0.134000 | 0.2860 | 2.21e-02 | 1.08e-06 |
| Interleukin-1 family signaling | 124 | 4.75e-13 | 1.54e-11 | 0.4590 | 0.240000 | 0.3910 | 4.08e-06 | 4.94e-14 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 124 | 2.98e-08 | 4.03e-07 | 0.3390 | 0.152000 | 0.3030 | 3.52e-03 | 5.68e-09 |
| Platelet Aggregation (Plug Formation) | 28 | 7.19e-05 | 3.63e-04 | 0.5750 | 0.325000 | 0.4750 | 2.93e-03 | 1.35e-05 |
| Hedgehog ligand biogenesis | 58 | 1.59e-06 | 1.43e-05 | 0.4610 | 0.242000 | 0.3920 | 1.43e-03 | 2.38e-07 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 179 | 5.49e-11 | 1.31e-09 | 0.3270 | -0.144000 | -0.2940 | 8.97e-04 | 1.14e-11 |
| Negative regulation of FGFR3 signaling | 20 | 2.05e-02 | 4.46e-02 | 0.4170 | 0.210000 | 0.3600 | 1.04e-01 | 5.34e-03 |
| rRNA processing in the nucleus and cytosol | 189 | 1.39e-11 | 3.64e-10 | 0.3280 | -0.145000 | -0.2950 | 5.89e-04 | 2.82e-12 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 1.58e-03 | 5.41e-03 | 0.6790 | 0.399000 | 0.5490 | 9.69e-03 | 3.77e-04 |
| MyD88-independent TLR4 cascade | 96 | 1.60e-09 | 2.69e-08 | 0.4390 | 0.227000 | 0.3760 | 1.22e-04 | 1.97e-10 |
| TRIF(TICAM1)-mediated TLR4 signaling | 96 | 1.60e-09 | 2.69e-08 | 0.4390 | 0.227000 | 0.3760 | 1.22e-04 | 1.97e-10 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 72 | 2.89e-05 | 1.65e-04 | 0.3490 | 0.161000 | 0.3090 | 1.82e-02 | 5.64e-06 |
| RAB GEFs exchange GTP for GDP on RABs | 87 | 4.32e-08 | 5.66e-07 | 0.4190 | 0.213000 | 0.3610 | 6.05e-04 | 5.86e-09 |
| Dectin-1 mediated noncanonical NF-kB signaling | 58 | 6.49e-06 | 4.49e-05 | 0.4330 | 0.223000 | 0.3710 | 3.31e-03 | 1.02e-06 |
| Infection with Mycobacterium tuberculosis | 26 | 4.34e-04 | 1.78e-03 | 0.5350 | 0.297000 | 0.4450 | 8.74e-03 | 8.63e-05 |
| Vpu mediated degradation of CD4 | 50 | 2.05e-05 | 1.22e-04 | 0.4450 | 0.232000 | 0.3800 | 4.52e-03 | 3.38e-06 |
| Signaling by NTRK1 (TRKA) | 100 | 2.82e-10 | 5.48e-09 | 0.4510 | 0.237000 | 0.3840 | 4.17e-05 | 3.32e-11 |
| Negative regulation of FGFR1 signaling | 24 | 2.05e-02 | 4.46e-02 | 0.3750 | 0.181000 | 0.3280 | 1.24e-01 | 5.43e-03 |
| Homologous DNA Pairing and Strand Exchange | 42 | 2.53e-04 | 1.11e-03 | 0.4230 | -0.217000 | -0.3630 | 1.51e-02 | 4.73e-05 |
| DNA Damage/Telomere Stress Induced Senescence | 44 | 1.50e-02 | 3.50e-02 | 0.2630 | 0.098000 | 0.2440 | 2.61e-01 | 5.16e-03 |
| Protein folding | 90 | 3.93e-05 | 2.09e-04 | 0.2970 | 0.124000 | 0.2690 | 4.19e-02 | 9.89e-06 |
| Hedgehog 'on' state | 74 | 1.26e-05 | 7.92e-05 | 0.3620 | 0.173000 | 0.3180 | 1.02e-02 | 2.24e-06 |
| VEGFA-VEGFR2 Pathway | 90 | 7.70e-07 | 7.39e-06 | 0.3680 | 0.178000 | 0.3220 | 3.61e-03 | 1.24e-07 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 58 | 1.33e-05 | 8.31e-05 | 0.4190 | 0.215000 | 0.3600 | 4.69e-03 | 2.17e-06 |
| MyD88 dependent cascade initiated on endosome | 88 | 3.62e-11 | 8.80e-10 | 0.5120 | 0.282000 | 0.4270 | 4.63e-06 | 4.44e-12 |
| Intra-Golgi traffic | 43 | 7.74e-03 | 2.06e-02 | 0.2980 | 0.126000 | 0.2700 | 1.54e-01 | 2.19e-03 |
| Downstream signaling events of B Cell Receptor (BCR) | 79 | 3.27e-05 | 1.79e-04 | 0.3290 | 0.149000 | 0.2930 | 2.19e-02 | 6.65e-06 |
| Transcriptional regulation by RUNX2 | 99 | 5.28e-05 | 2.79e-04 | 0.2730 | 0.107000 | 0.2510 | 6.46e-02 | 1.57e-05 |
| DNA methylation | 20 | 1.38e-04 | 6.42e-04 | 0.6680 | 0.395000 | 0.5390 | 2.21e-03 | 3.05e-05 |
| RNA Polymerase I Promoter Opening | 19 | 4.75e-06 | 3.44e-05 | 0.8140 | 0.499000 | 0.6430 | 1.63e-04 | 1.24e-06 |
| Signaling by NOTCH | 182 | 4.60e-15 | 2.51e-13 | 0.4050 | 0.206000 | 0.3490 | 1.67e-06 | 4.60e-16 |
| RHO GTPases Activate WASPs and WAVEs | 35 | 1.35e-10 | 3.02e-09 | 0.8170 | 0.502000 | 0.6450 | 2.79e-07 | 4.06e-11 |
| Semaphorin interactions | 57 | 5.79e-04 | 2.29e-03 | 0.3290 | 0.150000 | 0.2930 | 4.96e-02 | 1.29e-04 |
| RHO GTPases Activate NADPH Oxidases | 21 | 1.52e-05 | 9.29e-05 | 0.7330 | 0.442000 | 0.5840 | 4.58e-04 | 3.52e-06 |
| HuR (ELAVL1) binds and stabilizes mRNA | 10 | 2.24e-02 | 4.83e-02 | 0.6140 | 0.499000 | 0.3570 | 6.26e-03 | 5.08e-02 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 89 | 1.30e-11 | 3.47e-10 | 0.5210 | 0.290000 | 0.4330 | 2.18e-06 | 1.63e-12 |
| Toll Like Receptor 4 (TLR4) Cascade | 121 | 5.54e-15 | 2.90e-13 | 0.5110 | 0.283000 | 0.4250 | 7.62e-08 | 6.13e-16 |
| Degradation of GLI2 by the proteasome | 56 | 3.79e-06 | 2.92e-05 | 0.4560 | 0.243000 | 0.3860 | 1.62e-03 | 5.86e-07 |
| GLI3 is processed to GLI3R by the proteasome | 56 | 3.79e-06 | 2.92e-05 | 0.4560 | 0.243000 | 0.3860 | 1.62e-03 | 5.86e-07 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 87 | 1.44e-11 | 3.71e-10 | 0.5270 | 0.295000 | 0.4370 | 2.02e-06 | 1.85e-12 |
| Signaling by TGF-beta Receptor Complex | 72 | 1.39e-03 | 4.85e-03 | 0.2580 | 0.096800 | 0.2390 | 1.56e-01 | 4.56e-04 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 179 | 7.30e-12 | 2.07e-10 | 0.3510 | 0.167000 | 0.3090 | 1.16e-04 | 1.00e-12 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 50 | 2.44e-05 | 1.42e-04 | 0.4440 | 0.235000 | 0.3770 | 4.00e-03 | 4.05e-06 |
| p53-Independent DNA Damage Response | 50 | 2.44e-05 | 1.42e-04 | 0.4440 | 0.235000 | 0.3770 | 4.00e-03 | 4.05e-06 |
| p53-Independent G1/S DNA damage checkpoint | 50 | 2.44e-05 | 1.42e-04 | 0.4440 | 0.235000 | 0.3770 | 4.00e-03 | 4.05e-06 |
| Hyaluronan uptake and degradation | 12 | 3.64e-05 | 1.95e-04 | 0.9410 | 0.591000 | 0.7320 | 3.93e-04 | 1.12e-05 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 12 | 5.70e-03 | 1.60e-02 | 0.6580 | 0.390000 | 0.5300 | 1.94e-02 | 1.48e-03 |
| Cell recruitment (pro-inflammatory response) | 22 | 1.08e-03 | 3.92e-03 | 0.5510 | 0.453000 | 0.3130 | 2.35e-04 | 1.10e-02 |
| Purinergic signaling in leishmaniasis infection | 22 | 1.08e-03 | 3.92e-03 | 0.5510 | 0.453000 | 0.3130 | 2.35e-04 | 1.10e-02 |
| Regulation of Apoptosis | 51 | 9.67e-06 | 6.43e-05 | 0.4620 | 0.249000 | 0.3890 | 2.09e-03 | 1.56e-06 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 20 | 1.74e-04 | 7.90e-04 | 0.6600 | 0.392000 | 0.5310 | 2.42e-03 | 3.94e-05 |
| Neurodegenerative Diseases | 20 | 1.74e-04 | 7.90e-04 | 0.6600 | 0.392000 | 0.5310 | 2.42e-03 | 3.94e-05 |
| Platelet activation, signaling and aggregation | 219 | 2.66e-22 | 3.30e-20 | 0.4650 | 0.252000 | 0.3900 | 1.25e-10 | 2.28e-23 |
| EPH-ephrin mediated repulsion of cells | 39 | 5.57e-03 | 1.57e-02 | 0.3370 | 0.159000 | 0.2970 | 8.56e-02 | 1.35e-03 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 82 | 6.85e-09 | 1.06e-07 | 0.4670 | 0.254000 | 0.3910 | 6.84e-05 | 9.03e-10 |
| Peptide hormone metabolism | 49 | 9.38e-03 | 2.41e-02 | 0.2700 | 0.247000 | 0.1100 | 2.81e-03 | 1.83e-01 |
| Golgi-to-ER retrograde transport | 111 | 5.73e-10 | 1.03e-08 | 0.4220 | 0.222000 | 0.3580 | 5.20e-05 | 6.86e-11 |
| Plasma lipoprotein clearance | 28 | 1.36e-02 | 3.27e-02 | 0.3690 | 0.184000 | 0.3200 | 9.23e-02 | 3.42e-03 |
| E3 ubiquitin ligases ubiquitinate target proteins | 52 | 9.22e-05 | 4.52e-04 | 0.4040 | 0.210000 | 0.3450 | 8.87e-03 | 1.63e-05 |
| Activation of G protein gated Potassium channels | 20 | 1.03e-02 | 2.61e-02 | 0.4670 | 0.390000 | 0.2560 | 2.51e-03 | 4.79e-02 |
| G protein gated Potassium channels | 20 | 1.03e-02 | 2.61e-02 | 0.4670 | 0.390000 | 0.2560 | 2.51e-03 | 4.79e-02 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 20 | 1.03e-02 | 2.61e-02 | 0.4670 | 0.390000 | 0.2560 | 2.51e-03 | 4.79e-02 |
| Signaling by WNT | 253 | 9.98e-12 | 2.74e-10 | 0.2830 | 0.121000 | 0.2560 | 9.01e-04 | 2.45e-12 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 53 | 4.94e-04 | 1.98e-03 | 0.3550 | 0.175000 | 0.3090 | 2.75e-02 | 9.83e-05 |
| NIK-->noncanonical NF-kB signaling | 57 | 7.40e-06 | 5.01e-05 | 0.4420 | 0.238000 | 0.3720 | 1.89e-03 | 1.18e-06 |
| Intracellular signaling by second messengers | 271 | 5.16e-10 | 9.38e-09 | 0.2390 | 0.088400 | 0.2220 | 1.23e-02 | 2.91e-10 |
| Regulation of ornithine decarboxylase (ODC) | 49 | 2.32e-06 | 1.93e-05 | 0.5070 | 0.285000 | 0.4190 | 5.52e-04 | 3.84e-07 |
| ER Quality Control Compartment (ERQC) | 21 | 1.14e-02 | 2.82e-02 | 0.4490 | 0.243000 | 0.3770 | 5.37e-02 | 2.79e-03 |
| Toll Like Receptor 9 (TLR9) Cascade | 92 | 5.72e-11 | 1.34e-09 | 0.4990 | 0.280000 | 0.4130 | 3.48e-06 | 7.57e-12 |
| Metabolism of carbohydrates | 241 | 1.94e-08 | 2.79e-07 | 0.2280 | 0.081000 | 0.2130 | 3.03e-02 | 1.14e-08 |
| PIP3 activates AKT signaling | 239 | 3.36e-09 | 5.51e-08 | 0.2470 | 0.095800 | 0.2280 | 1.08e-02 | 1.32e-09 |
| Signaling by RAF1 mutants | 34 | 7.43e-06 | 5.01e-05 | 0.5890 | 0.345000 | 0.4770 | 4.96e-04 | 1.47e-06 |
| RNA Polymerase II Pre-transcription Events | 78 | 7.73e-03 | 2.06e-02 | 0.1990 | 0.059100 | 0.1900 | 3.67e-01 | 3.63e-03 |
| Metabolism of nucleotides | 86 | 1.35e-03 | 4.75e-03 | 0.2360 | 0.219000 | 0.0876 | 4.53e-04 | 1.60e-01 |
| Transcriptional regulation by RUNX1 | 184 | 3.25e-06 | 2.56e-05 | 0.2180 | 0.074200 | 0.2050 | 8.24e-02 | 1.69e-06 |
| APC/C:Cdc20 mediated degradation of Securin | 66 | 7.95e-05 | 3.97e-04 | 0.3570 | 0.179000 | 0.3090 | 1.20e-02 | 1.42e-05 |
| G-protein beta:gamma signalling | 29 | 7.26e-04 | 2.83e-03 | 0.4920 | 0.277000 | 0.4060 | 9.91e-03 | 1.51e-04 |
| Antimicrobial peptides | 33 | 2.72e-06 | 2.18e-05 | 0.6260 | 0.503000 | 0.3730 | 5.78e-07 | 2.08e-04 |
| Diseases of programmed cell death | 27 | 1.29e-02 | 3.12e-02 | 0.3840 | 0.199000 | 0.3280 | 7.39e-02 | 3.17e-03 |
| The citric acid (TCA) cycle and respiratory electron transport | 172 | 2.28e-09 | 3.79e-08 | 0.3140 | 0.148000 | 0.2770 | 8.13e-04 | 3.49e-10 |
| Hedgehog 'off' state | 91 | 9.82e-04 | 3.63e-03 | 0.2360 | 0.089200 | 0.2180 | 1.41e-01 | 3.18e-04 |
| Asparagine N-linked glycosylation | 269 | 4.80e-18 | 4.09e-16 | 0.3670 | 0.187000 | 0.3160 | 1.32e-07 | 4.39e-19 |
| Signaling by NTRKs | 114 | 2.13e-11 | 5.28e-10 | 0.4540 | 0.250000 | 0.3790 | 3.88e-06 | 2.57e-12 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | 40 | 4.40e-03 | 1.28e-02 | 0.3460 | 0.172000 | 0.3010 | 6.04e-02 | 1.00e-03 |
| Signaling by high-kinase activity BRAF mutants | 31 | 5.20e-06 | 3.65e-05 | 0.6300 | 0.376000 | 0.5050 | 2.88e-04 | 1.13e-06 |
| DNA strand elongation | 32 | 3.38e-06 | 2.65e-05 | 0.6310 | -0.377000 | -0.5060 | 2.23e-04 | 7.32e-07 |
| Platelet Adhesion to exposed collagen | 13 | 1.31e-03 | 4.62e-03 | 0.7240 | 0.572000 | 0.4430 | 3.56e-04 | 5.66e-03 |
| G-protein mediated events | 44 | 3.59e-03 | 1.09e-02 | 0.3340 | 0.163000 | 0.2920 | 6.07e-02 | 8.17e-04 |
| Golgi Associated Vesicle Biogenesis | 55 | 4.03e-06 | 3.04e-05 | 0.4660 | 0.260000 | 0.3870 | 8.66e-04 | 6.62e-07 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 24 | 2.09e-03 | 6.90e-03 | 0.5010 | -0.285000 | -0.4120 | 1.58e-02 | 4.70e-04 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 38 | 1.15e-05 | 7.30e-05 | 0.5450 | 0.316000 | 0.4440 | 7.37e-04 | 2.20e-06 |
| Signaling by RAS mutants | 38 | 1.15e-05 | 7.30e-05 | 0.5450 | 0.316000 | 0.4440 | 7.37e-04 | 2.20e-06 |
| Signaling by moderate kinase activity BRAF mutants | 38 | 1.15e-05 | 7.30e-05 | 0.5450 | 0.316000 | 0.4440 | 7.37e-04 | 2.20e-06 |
| Signaling downstream of RAS mutants | 38 | 1.15e-05 | 7.30e-05 | 0.5450 | 0.316000 | 0.4440 | 7.37e-04 | 2.20e-06 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 36 | 3.45e-05 | 1.86e-04 | 0.5310 | 0.308000 | 0.4330 | 1.41e-03 | 6.76e-06 |
| MHC class II antigen presentation | 101 | 3.43e-04 | 1.45e-03 | 0.2450 | 0.098700 | 0.2240 | 8.66e-02 | 9.66e-05 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 64 | 7.19e-05 | 3.63e-04 | 0.3680 | 0.190000 | 0.3160 | 8.57e-03 | 1.26e-05 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 12 | 7.06e-06 | 4.81e-05 | 1.0200 | 0.656000 | 0.7810 | 8.39e-05 | 2.80e-06 |
| alpha-linolenic acid (ALA) metabolism | 12 | 7.06e-06 | 4.81e-05 | 1.0200 | 0.656000 | 0.7810 | 8.39e-05 | 2.80e-06 |
| Plasma lipoprotein assembly, remodeling, and clearance | 52 | 2.27e-03 | 7.20e-03 | 0.3180 | 0.154000 | 0.2790 | 5.50e-02 | 5.04e-04 |
| Response of EIF2AK1 (HRI) to heme deficiency | 14 | 1.62e-02 | 3.72e-02 | 0.5410 | 0.439000 | 0.3150 | 4.41e-03 | 4.15e-02 |
| COPI-dependent Golgi-to-ER retrograde traffic | 78 | 3.77e-04 | 1.56e-03 | 0.2920 | 0.135000 | 0.2580 | 3.89e-02 | 8.01e-05 |
| Class I MHC mediated antigen processing & presentation | 347 | 1.00e-11 | 2.74e-10 | 0.2360 | 0.093700 | 0.2170 | 2.72e-03 | 4.12e-12 |
| Signaling by Receptor Tyrosine Kinases | 408 | 7.11e-22 | 8.08e-20 | 0.3270 | 0.161000 | 0.2840 | 2.19e-08 | 6.76e-23 |
| Neddylation | 217 | 6.19e-07 | 6.12e-06 | 0.2180 | 0.080500 | 0.2030 | 4.10e-02 | 2.57e-07 |
| Beta-catenin independent WNT signaling | 136 | 4.08e-07 | 4.53e-06 | 0.3060 | 0.147000 | 0.2680 | 3.15e-03 | 6.53e-08 |
| Metabolism of steroids | 116 | 5.72e-05 | 2.99e-04 | 0.2600 | 0.113000 | 0.2340 | 3.49e-02 | 1.30e-05 |
| EPH-Ephrin signaling | 78 | 1.61e-10 | 3.53e-09 | 0.5370 | 0.315000 | 0.4360 | 1.52e-06 | 2.84e-11 |
| G beta:gamma signalling through CDC42 | 17 | 5.40e-03 | 1.53e-02 | 0.5550 | 0.448000 | 0.3280 | 1.39e-03 | 1.90e-02 |
| CLEC7A (Dectin-1) signaling | 96 | 5.48e-08 | 6.92e-07 | 0.4070 | 0.222000 | 0.3410 | 1.66e-04 | 7.64e-09 |
| Toll-like Receptor Cascades | 143 | 4.51e-16 | 3.11e-14 | 0.4950 | 0.286000 | 0.4040 | 3.68e-09 | 6.79e-17 |
| Cellular Senescence | 144 | 6.90e-06 | 4.75e-05 | 0.2590 | 0.114000 | 0.2320 | 1.85e-02 | 1.48e-06 |
| Diseases of signal transduction by growth factor receptors and second messengers | 339 | 7.52e-16 | 4.88e-14 | 0.3000 | 0.145000 | 0.2630 | 4.51e-06 | 8.91e-17 |
| Stabilization of p53 | 54 | 3.09e-04 | 1.33e-03 | 0.3730 | 0.199000 | 0.3160 | 1.16e-02 | 5.82e-05 |
| Sphingolipid metabolism | 78 | 1.41e-04 | 6.55e-04 | 0.3180 | 0.158000 | 0.2750 | 1.56e-02 | 2.61e-05 |
| Rho GTPase cycle | 125 | 9.48e-04 | 3.54e-03 | 0.1970 | 0.068000 | 0.1840 | 1.89e-01 | 3.69e-04 |
| p75 NTR receptor-mediated signalling | 88 | 1.50e-03 | 5.15e-03 | 0.2410 | 0.102000 | 0.2190 | 9.72e-02 | 3.92e-04 |
| Regulation of RUNX2 expression and activity | 66 | 8.78e-04 | 3.33e-03 | 0.3060 | 0.150000 | 0.2660 | 3.49e-02 | 1.81e-04 |
| Transcriptional regulation by RUNX3 | 90 | 5.23e-04 | 2.08e-03 | 0.2630 | 0.119000 | 0.2350 | 5.11e-02 | 1.18e-04 |
| Platelet homeostasis | 67 | 1.03e-04 | 4.98e-04 | 0.3560 | 0.187000 | 0.3030 | 8.06e-03 | 1.83e-05 |
| CDT1 association with the CDC6:ORC:origin complex | 57 | 8.03e-04 | 3.09e-03 | 0.3370 | 0.174000 | 0.2890 | 2.33e-02 | 1.60e-04 |
| Signaling by Non-Receptor Tyrosine Kinases | 47 | 2.59e-03 | 8.05e-03 | 0.3400 | 0.176000 | 0.2910 | 3.72e-02 | 5.59e-04 |
| Signaling by PTK6 | 47 | 2.59e-03 | 8.05e-03 | 0.3400 | 0.176000 | 0.2910 | 3.72e-02 | 5.59e-04 |
| HDR through Single Strand Annealing (SSA) | 37 | 1.27e-02 | 3.11e-02 | 0.3260 | -0.165000 | -0.2800 | 8.17e-02 | 3.15e-03 |
| Chaperonin-mediated protein folding | 84 | 6.02e-05 | 3.11e-04 | 0.3220 | 0.163000 | 0.2780 | 9.84e-03 | 1.06e-05 |
| Pre-NOTCH Transcription and Translation | 49 | 3.64e-05 | 1.95e-04 | 0.4520 | 0.257000 | 0.3720 | 1.85e-03 | 6.78e-06 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 48 | 5.29e-05 | 2.79e-04 | 0.4480 | 0.254000 | 0.3690 | 2.32e-03 | 9.94e-06 |
| Amyloid fiber formation | 51 | 1.27e-08 | 1.90e-07 | 0.6030 | 0.365000 | 0.4800 | 6.35e-06 | 3.05e-09 |
| Antigen processing: Ubiquitination & Proteasome degradation | 286 | 3.40e-06 | 2.65e-05 | 0.1660 | 0.045900 | 0.1590 | 1.82e-01 | 3.58e-06 |
| RAB geranylgeranylation | 61 | 1.95e-06 | 1.70e-05 | 0.4610 | 0.264000 | 0.3770 | 3.62e-04 | 3.41e-07 |
| Post-translational protein phosphorylation | 68 | 4.25e-07 | 4.63e-06 | 0.4610 | 0.264000 | 0.3780 | 1.62e-04 | 7.22e-08 |
| Signaling by Hedgehog | 119 | 1.17e-04 | 5.58e-04 | 0.2490 | 0.110000 | 0.2230 | 3.80e-02 | 2.61e-05 |
| PLC beta mediated events | 43 | 2.98e-03 | 9.20e-03 | 0.3540 | 0.188000 | 0.3010 | 3.33e-02 | 6.50e-04 |
| SCF(Skp2)-mediated degradation of p27/p21 | 60 | 9.28e-04 | 3.49e-03 | 0.3250 | 0.167000 | 0.2790 | 2.56e-02 | 1.87e-04 |
| Fc epsilon receptor (FCERI) signaling | 189 | 1.33e-05 | 8.31e-05 | 0.2110 | 0.194000 | 0.0832 | 4.04e-06 | 4.86e-02 |
| NS1 Mediated Effects on Host Pathways | 40 | 1.52e-02 | 3.54e-02 | 0.3050 | -0.153000 | -0.2640 | 9.38e-02 | 3.85e-03 |
| Cargo concentration in the ER | 30 | 1.44e-06 | 1.32e-05 | 0.6810 | 0.423000 | 0.5340 | 6.09e-05 | 4.19e-07 |
| Cyclin A:Cdk2-associated events at S phase entry | 85 | 5.90e-03 | 1.65e-02 | 0.2140 | 0.085400 | 0.1960 | 1.73e-01 | 1.78e-03 |
| Signaling by NOTCH1 | 66 | 8.99e-05 | 4.44e-04 | 0.3650 | 0.197000 | 0.3070 | 5.71e-03 | 1.60e-05 |
| Assembly of the pre-replicative complex | 66 | 6.21e-03 | 1.71e-02 | 0.2530 | 0.115000 | 0.2250 | 1.07e-01 | 1.58e-03 |
| L1CAM interactions | 83 | 5.12e-06 | 3.62e-05 | 0.3730 | 0.203000 | 0.3130 | 1.35e-03 | 8.17e-07 |
| CDK-mediated phosphorylation and removal of Cdc6 | 71 | 2.40e-04 | 1.05e-03 | 0.3280 | 0.171000 | 0.2800 | 1.29e-02 | 4.45e-05 |
| Potential therapeutics for SARS | 78 | 4.28e-03 | 1.26e-02 | 0.2380 | 0.104000 | 0.2130 | 1.12e-01 | 1.11e-03 |
| Metabolism of lipids | 619 | 2.02e-20 | 1.97e-18 | 0.2490 | 0.113000 | 0.2220 | 1.62e-06 | 3.83e-21 |
| FLT3 Signaling | 242 | 4.37e-07 | 4.68e-06 | 0.2170 | 0.089500 | 0.1980 | 1.65e-02 | 1.16e-07 |
| mRNA Splicing - Major Pathway | 179 | 1.41e-02 | 3.35e-02 | 0.0844 | -0.028900 | 0.0793 | 5.05e-01 | 6.71e-02 |
| RHO GTPase Effectors | 248 | 1.12e-12 | 3.47e-11 | 0.3190 | 0.165000 | 0.2730 | 7.43e-06 | 1.19e-13 |
| Amino acids regulate mTORC1 | 50 | 1.38e-04 | 6.44e-04 | 0.4160 | 0.235000 | 0.3430 | 3.99e-03 | 2.68e-05 |
| Formation of the beta-catenin:TCF transactivating complex | 46 | 1.99e-02 | 4.36e-02 | 0.2710 | 0.130000 | 0.2380 | 1.27e-01 | 5.30e-03 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 181 | 2.01e-04 | 8.97e-04 | 0.1810 | -0.062100 | -0.1700 | 1.50e-01 | 8.33e-05 |
| p53-Dependent G1 DNA Damage Response | 63 | 1.15e-03 | 4.11e-03 | 0.3130 | 0.161000 | 0.2680 | 2.74e-02 | 2.34e-04 |
| p53-Dependent G1/S DNA damage checkpoint | 63 | 1.15e-03 | 4.11e-03 | 0.3130 | 0.161000 | 0.2680 | 2.74e-02 | 2.34e-04 |
| Signaling by Rho GTPases | 364 | 9.12e-14 | 3.11e-12 | 0.2690 | 0.129000 | 0.2360 | 2.29e-05 | 1.15e-14 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 53 | 2.23e-03 | 7.10e-03 | 0.3260 | 0.171000 | 0.2770 | 3.08e-02 | 4.75e-04 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | 53 | 2.23e-03 | 7.10e-03 | 0.3260 | 0.171000 | 0.2770 | 3.08e-02 | 4.75e-04 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 53 | 2.23e-03 | 7.10e-03 | 0.3260 | 0.171000 | 0.2770 | 3.08e-02 | 4.75e-04 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | 53 | 2.23e-03 | 7.10e-03 | 0.3260 | 0.171000 | 0.2770 | 3.08e-02 | 4.75e-04 |
| Signaling by NOTCH1 in Cancer | 53 | 2.23e-03 | 7.10e-03 | 0.3260 | 0.171000 | 0.2770 | 3.08e-02 | 4.75e-04 |
| ADP signalling through P2Y purinoceptor 12 | 18 | 3.60e-03 | 1.09e-02 | 0.5650 | 0.449000 | 0.3430 | 9.80e-04 | 1.18e-02 |
| MTOR signalling | 39 | 1.11e-04 | 5.35e-04 | 0.4840 | 0.285000 | 0.3910 | 2.05e-03 | 2.41e-05 |
| Opioid Signalling | 75 | 1.44e-05 | 8.82e-05 | 0.3780 | 0.209000 | 0.3150 | 1.71e-03 | 2.44e-06 |
| RAF/MAP kinase cascade | 228 | 2.10e-06 | 1.78e-05 | 0.2110 | 0.087300 | 0.1920 | 2.32e-02 | 5.48e-07 |
| Signaling by the B Cell Receptor (BCR) | 161 | 2.47e-03 | 7.72e-03 | 0.1520 | 0.146000 | 0.0421 | 1.38e-03 | 3.57e-01 |
| G beta:gamma signalling through BTK | 15 | 2.31e-02 | 4.93e-02 | 0.5040 | 0.404000 | 0.3010 | 6.74e-03 | 4.38e-02 |
| Deubiquitination | 240 | 3.64e-08 | 4.86e-07 | 0.2460 | 0.115000 | 0.2180 | 2.16e-03 | 5.99e-09 |
| Cyclin E associated events during G1/S transition | 83 | 4.07e-03 | 1.21e-02 | 0.2340 | 0.106000 | 0.2090 | 9.41e-02 | 1.01e-03 |
| ABC-family proteins mediated transport | 92 | 5.43e-05 | 2.86e-04 | 0.3140 | 0.165000 | 0.2670 | 6.13e-03 | 9.34e-06 |
| Macroautophagy | 109 | 2.06e-07 | 2.37e-06 | 0.3690 | 0.205000 | 0.3070 | 2.14e-04 | 3.09e-08 |
| Neutrophil degranulation | 456 | 1.26e-111 | 1.72e-108 | 0.7700 | 0.491000 | 0.5930 | 9.83e-73 | 2.07e-105 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 75 | 3.48e-04 | 1.47e-03 | 0.3140 | 0.165000 | 0.2660 | 1.34e-02 | 6.59e-05 |
| Pentose phosphate pathway | 13 | 3.27e-03 | 1.00e-02 | 0.6770 | 0.425000 | 0.5260 | 7.94e-03 | 1.01e-03 |
| Regulation of TP53 Activity | 152 | 7.37e-03 | 1.97e-02 | 0.1370 | -0.133000 | -0.0317 | 4.70e-03 | 5.00e-01 |
| Cristae formation | 31 | 1.27e-02 | 3.11e-02 | 0.3680 | 0.205000 | 0.3060 | 4.85e-02 | 3.21e-03 |
| Retrograde transport at the Trans-Golgi-Network | 49 | 1.99e-02 | 4.36e-02 | 0.2650 | 0.130000 | 0.2310 | 1.16e-01 | 5.24e-03 |
| MAPK1/MAPK3 signaling | 233 | 7.58e-07 | 7.33e-06 | 0.2230 | 0.099300 | 0.2000 | 9.02e-03 | 1.52e-07 |
| mRNA Splicing | 187 | 2.22e-02 | 4.79e-02 | 0.0805 | -0.021200 | 0.0777 | 6.18e-01 | 6.69e-02 |
| MET activates RAP1 and RAC1 | 10 | 4.02e-03 | 1.20e-02 | 0.7610 | 0.487000 | 0.5850 | 7.65e-03 | 1.37e-03 |
| Autophagy | 123 | 3.51e-10 | 6.74e-09 | 0.4200 | 0.244000 | 0.3420 | 2.86e-06 | 5.90e-11 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 74 | 4.48e-04 | 1.82e-03 | 0.3120 | 0.167000 | 0.2640 | 1.30e-02 | 8.63e-05 |
| Hyaluronan metabolism | 15 | 8.47e-04 | 3.24e-03 | 0.7020 | 0.446000 | 0.5430 | 2.80e-03 | 2.74e-04 |
| Nucleobase catabolism | 28 | 1.07e-02 | 2.71e-02 | 0.4000 | 0.327000 | 0.2310 | 2.77e-03 | 3.47e-02 |
| Collagen degradation | 28 | 3.55e-04 | 1.49e-03 | 0.5400 | 0.331000 | 0.4260 | 2.45e-03 | 9.41e-05 |
| Post-translational protein modification | 1183 | 2.92e-28 | 4.42e-26 | 0.2150 | 0.097100 | 0.1920 | 1.84e-08 | 7.00e-29 |
| SIRT1 negatively regulates rRNA expression | 24 | 9.93e-03 | 2.54e-02 | 0.4390 | 0.354000 | 0.2600 | 2.67e-03 | 2.73e-02 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 12 | 4.56e-04 | 1.84e-03 | 0.8230 | 0.627000 | 0.5330 | 1.71e-04 | 1.39e-03 |
| Estrogen-dependent gene expression | 98 | 8.66e-05 | 4.31e-04 | 0.2990 | 0.159000 | 0.2530 | 6.47e-03 | 1.53e-05 |
| Signaling by Nuclear Receptors | 214 | 5.26e-09 | 8.24e-08 | 0.2890 | 0.153000 | 0.2450 | 1.17e-04 | 6.64e-10 |
| Activation of Matrix Metalloproteinases | 23 | 8.98e-03 | 2.31e-02 | 0.4550 | 0.365000 | 0.2730 | 2.47e-03 | 2.36e-02 |
| Erythropoietin activates RAS | 13 | 1.50e-02 | 3.50e-02 | 0.5780 | 0.360000 | 0.4520 | 2.45e-02 | 4.74e-03 |
| Developmental Biology | 726 | 1.61e-13 | 5.35e-12 | 0.1790 | 0.072300 | 0.1630 | 9.06e-04 | 6.48e-14 |
| Unfolded Protein Response (UPR) | 87 | 5.71e-03 | 1.60e-02 | 0.2260 | 0.108000 | 0.1990 | 8.15e-02 | 1.37e-03 |
| Protein ubiquitination | 72 | 4.98e-06 | 3.55e-05 | 0.4130 | 0.243000 | 0.3330 | 3.59e-04 | 1.01e-06 |
| IKK complex recruitment mediated by RIP1 | 23 | 6.89e-03 | 1.88e-02 | 0.4690 | 0.284000 | 0.3740 | 1.84e-02 | 1.91e-03 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 110 | 1.76e-02 | 3.94e-02 | 0.1640 | -0.061900 | -0.1520 | 2.62e-01 | 5.96e-03 |
| B-WICH complex positively regulates rRNA expression | 44 | 1.80e-02 | 4.01e-02 | 0.2930 | 0.247000 | 0.1570 | 4.61e-03 | 7.15e-02 |
| G1/S DNA Damage Checkpoints | 65 | 1.49e-03 | 5.13e-03 | 0.3090 | 0.169000 | 0.2580 | 1.85e-02 | 3.13e-04 |
| C-type lectin receptors (CLRs) | 128 | 9.15e-08 | 1.10e-06 | 0.3530 | 0.201000 | 0.2900 | 8.79e-05 | 1.46e-08 |
| Interleukin-4 and Interleukin-13 signaling | 92 | 1.59e-07 | 1.87e-06 | 0.4140 | 0.334000 | 0.2450 | 3.19e-08 | 4.71e-05 |
| APC/C-mediated degradation of cell cycle proteins | 86 | 2.32e-03 | 7.29e-03 | 0.2530 | 0.130000 | 0.2170 | 3.77e-02 | 4.98e-04 |
| Regulation of mitotic cell cycle | 86 | 2.32e-03 | 7.29e-03 | 0.2530 | 0.130000 | 0.2170 | 3.77e-02 | 4.98e-04 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 78 | 2.39e-06 | 1.95e-05 | 0.4090 | 0.242000 | 0.3290 | 2.22e-04 | 4.88e-07 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 109 | 2.28e-02 | 4.89e-02 | 0.1600 | -0.060700 | -0.1480 | 2.74e-01 | 7.77e-03 |
| Programmed Cell Death | 179 | 2.12e-11 | 5.28e-10 | 0.3700 | 0.215000 | 0.3010 | 7.04e-07 | 3.45e-12 |
| HIV Infection | 224 | 3.25e-05 | 1.79e-04 | 0.1960 | 0.088300 | 0.1750 | 2.28e-02 | 6.70e-06 |
| rRNA processing | 218 | 4.60e-10 | 8.59e-09 | 0.3090 | -0.171000 | -0.2570 | 1.37e-05 | 5.96e-11 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 72 | 4.50e-04 | 1.83e-03 | 0.3220 | 0.181000 | 0.2670 | 7.87e-03 | 9.12e-05 |
| Signal Transduction | 1869 | 1.00e-35 | 2.74e-33 | 0.1980 | 0.090300 | 0.1760 | 1.01e-10 | 2.34e-36 |
| Oncogenic MAPK signaling | 73 | 1.58e-06 | 1.43e-05 | 0.4310 | 0.259000 | 0.3450 | 1.27e-04 | 3.54e-07 |
| Phospholipid metabolism | 184 | 1.17e-06 | 1.08e-05 | 0.2630 | 0.138000 | 0.2230 | 1.20e-03 | 1.73e-07 |
| Apoptosis | 167 | 4.84e-10 | 8.92e-09 | 0.3570 | 0.207000 | 0.2920 | 4.01e-06 | 7.84e-11 |
| HDR through Homologous Recombination (HRR) | 66 | 5.92e-03 | 1.65e-02 | 0.2690 | -0.143000 | -0.2280 | 4.42e-02 | 1.36e-03 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 71 | 4.48e-04 | 1.82e-03 | 0.3250 | 0.184000 | 0.2680 | 7.38e-03 | 9.15e-05 |
| Regulation of APC/C activators between G1/S and early anaphase | 79 | 1.92e-03 | 6.42e-03 | 0.2720 | 0.146000 | 0.2300 | 2.51e-02 | 4.06e-04 |
| Response to elevated platelet cytosolic Ca2+ | 108 | 8.50e-17 | 6.44e-15 | 0.5990 | 0.380000 | 0.4630 | 9.02e-12 | 8.21e-17 |
| Uptake and actions of bacterial toxins | 27 | 1.61e-02 | 3.70e-02 | 0.3920 | 0.232000 | 0.3160 | 3.68e-02 | 4.49e-03 |
| TP53 Regulates Metabolic Genes | 85 | 3.16e-04 | 1.35e-03 | 0.3020 | 0.168000 | 0.2510 | 7.32e-03 | 6.18e-05 |
| Generation of second messenger molecules | 38 | 4.43e-07 | 4.68e-06 | 0.6360 | -0.406000 | -0.4890 | 1.45e-05 | 1.82e-07 |
| Mitotic G2-G2/M phases | 180 | 1.19e-02 | 2.92e-02 | 0.1270 | 0.039000 | 0.1210 | 3.67e-01 | 5.23e-03 |
| G2/M Transition | 178 | 1.77e-02 | 3.95e-02 | 0.1180 | 0.032600 | 0.1140 | 4.54e-01 | 8.75e-03 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 1.21e-02 | 2.96e-02 | 0.2850 | 0.157000 | 0.2380 | 5.05e-02 | 3.00e-03 |
| Thromboxane signalling through TP receptor | 20 | 2.32e-03 | 7.29e-03 | 0.5630 | 0.436000 | 0.3560 | 7.37e-04 | 5.86e-03 |
| Condensation of Prophase Chromosomes | 29 | 1.33e-02 | 3.22e-02 | 0.3880 | 0.231000 | 0.3110 | 3.12e-02 | 3.72e-03 |
| Mitotic Anaphase | 223 | 5.90e-04 | 2.32e-03 | 0.1620 | 0.067200 | 0.1470 | 8.36e-02 | 1.56e-04 |
| Nervous system development | 470 | 4.39e-07 | 4.68e-06 | 0.1550 | 0.062500 | 0.1420 | 2.02e-02 | 1.28e-07 |
| Protein localization | 157 | 2.13e-03 | 6.95e-03 | 0.1800 | 0.081100 | 0.1610 | 7.96e-02 | 5.13e-04 |
| Translocation of ZAP-70 to Immunological synapse | 24 | 7.25e-11 | 1.67e-09 | 1.0200 | -0.679000 | -0.7590 | 8.22e-09 | 1.20e-10 |
| Signalling to ERKs | 31 | 5.93e-04 | 2.33e-03 | 0.4990 | 0.311000 | 0.3900 | 2.72e-03 | 1.73e-04 |
| Muscle contraction | 135 | 7.75e-03 | 2.06e-02 | 0.1710 | 0.075400 | 0.1540 | 1.30e-01 | 2.07e-03 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 15 | 5.03e-03 | 1.44e-02 | 0.6090 | 0.390000 | 0.4680 | 8.96e-03 | 1.72e-03 |
| Mitotic Metaphase and Anaphase | 224 | 9.38e-04 | 3.51e-03 | 0.1560 | 0.064700 | 0.1420 | 9.52e-02 | 2.52e-04 |
| Leishmania infection | 243 | 2.02e-06 | 1.73e-05 | 0.2220 | 0.191000 | 0.1140 | 3.05e-07 | 2.20e-03 |
| ATF6 (ATF6-alpha) activates chaperone genes | 10 | 2.29e-02 | 4.89e-02 | 0.6310 | 0.482000 | 0.4060 | 8.26e-03 | 2.62e-02 |
| Platelet degranulation | 104 | 4.56e-16 | 3.11e-14 | 0.5980 | 0.383000 | 0.4590 | 1.42e-11 | 5.60e-16 |
| Signaling by MET | 60 | 4.00e-06 | 3.03e-05 | 0.4630 | 0.287000 | 0.3630 | 1.19e-04 | 1.14e-06 |
| The NLRP3 inflammasome | 15 | 1.50e-03 | 5.15e-03 | 0.6770 | 0.515000 | 0.4390 | 5.56e-04 | 3.22e-03 |
| Axon guidance | 451 | 4.60e-07 | 4.83e-06 | 0.1630 | 0.071100 | 0.1460 | 9.71e-03 | 9.82e-08 |
| Formation of a pool of free 40S subunits | 99 | 1.98e-03 | 6.58e-03 | 0.2430 | -0.130000 | -0.2050 | 2.56e-02 | 4.19e-04 |
| MAPK family signaling cascades | 267 | 6.89e-07 | 6.71e-06 | 0.2210 | 0.114000 | 0.1890 | 1.29e-03 | 1.00e-07 |
| Apoptotic execution phase | 45 | 1.00e-02 | 2.57e-02 | 0.3190 | 0.185000 | 0.2590 | 3.19e-02 | 2.61e-03 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 87 | 2.15e-06 | 1.81e-05 | 0.3910 | 0.237000 | 0.3120 | 1.32e-04 | 5.06e-07 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 99 | 1.00e-03 | 3.66e-03 | 0.2580 | -0.142000 | -0.2160 | 1.48e-02 | 2.06e-04 |
| Peroxisomal protein import | 57 | 1.96e-02 | 4.33e-02 | 0.2570 | 0.141000 | 0.2140 | 6.55e-02 | 5.11e-03 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 29 | 7.17e-03 | 1.94e-02 | 0.4180 | 0.257000 | 0.3300 | 1.67e-02 | 2.09e-03 |
| Selenoamino acid metabolism | 113 | 3.57e-04 | 1.49e-03 | 0.2600 | -0.143000 | -0.2170 | 8.43e-03 | 6.97e-05 |
| Vesicle-mediated transport | 644 | 3.04e-33 | 6.90e-31 | 0.3470 | 0.207000 | 0.2790 | 3.64e-19 | 1.28e-33 |
| G-protein activation | 23 | 6.57e-03 | 1.80e-02 | 0.4770 | 0.371000 | 0.2990 | 2.06e-03 | 1.30e-02 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 93 | 4.02e-04 | 1.65e-03 | 0.2870 | -0.164000 | -0.2360 | 6.29e-03 | 8.33e-05 |
| Syndecan interactions | 19 | 1.44e-02 | 3.41e-02 | 0.4820 | 0.375000 | 0.3030 | 4.68e-03 | 2.23e-02 |
| Diseases associated with the TLR signaling cascade | 23 | 1.11e-05 | 7.23e-05 | 0.7250 | 0.476000 | 0.5480 | 7.78e-05 | 5.43e-06 |
| Diseases of Immune System | 23 | 1.11e-05 | 7.23e-05 | 0.7250 | 0.476000 | 0.5480 | 7.78e-05 | 5.43e-06 |
| Telomere C-strand (Lagging Strand) Synthesis | 34 | 6.69e-04 | 2.61e-03 | 0.4730 | -0.297000 | -0.3680 | 2.70e-03 | 2.04e-04 |
| Degradation of the extracellular matrix | 78 | 9.03e-04 | 3.41e-03 | 0.2990 | 0.173000 | 0.2430 | 8.34e-03 | 2.01e-04 |
| Death Receptor Signalling | 131 | 6.12e-03 | 1.69e-02 | 0.1850 | 0.091200 | 0.1610 | 7.16e-02 | 1.44e-03 |
| Metabolism of polyamines | 57 | 2.19e-05 | 1.29e-04 | 0.4420 | 0.276000 | 0.3460 | 3.18e-04 | 6.38e-06 |
| Transcriptional Regulation by TP53 | 351 | 8.66e-03 | 2.27e-02 | 0.0840 | 0.013400 | 0.0830 | 6.67e-01 | 7.58e-03 |
| Fatty acid metabolism | 150 | 9.61e-04 | 3.58e-03 | 0.2060 | 0.107000 | 0.1760 | 2.36e-02 | 1.93e-04 |
| Integration of energy metabolism | 86 | 4.32e-06 | 3.18e-05 | 0.3840 | 0.235000 | 0.3040 | 1.64e-04 | 1.10e-06 |
| G beta:gamma signalling through PLC beta | 17 | 1.49e-02 | 3.48e-02 | 0.5090 | 0.393000 | 0.3240 | 5.06e-03 | 2.07e-02 |
| Presynaptic function of Kainate receptors | 17 | 1.49e-02 | 3.48e-02 | 0.5090 | 0.393000 | 0.3240 | 5.06e-03 | 2.07e-02 |
| Formation of the cornified envelope | 21 | 1.08e-02 | 2.73e-02 | 0.4740 | 0.368000 | 0.2990 | 3.53e-03 | 1.77e-02 |
| Metabolism of proteins | 1706 | 1.53e-28 | 2.61e-26 | 0.1910 | 0.096700 | 0.1650 | 3.22e-11 | 1.16e-29 |
| PD-1 signaling | 28 | 3.99e-08 | 5.28e-07 | 0.8050 | -0.535000 | -0.6020 | 9.47e-07 | 3.51e-08 |
| Diseases associated with O-glycosylation of proteins | 47 | 1.63e-02 | 3.72e-02 | 0.2960 | -0.240000 | -0.1740 | 4.49e-03 | 3.87e-02 |
| G alpha (z) signalling events | 36 | 8.29e-03 | 2.18e-02 | 0.3700 | 0.227000 | 0.2920 | 1.85e-02 | 2.42e-03 |
| NOTCH1 Intracellular Domain Regulates Transcription | 44 | 2.38e-03 | 7.44e-03 | 0.3760 | 0.231000 | 0.2960 | 7.89e-03 | 6.70e-04 |
| Factors involved in megakaryocyte development and platelet production | 116 | 2.12e-03 | 6.95e-03 | 0.2250 | 0.124000 | 0.1880 | 2.15e-02 | 4.57e-04 |
| Erythrocytes take up carbon dioxide and release oxygen | 11 | 3.19e-05 | 1.76e-04 | 1.0000 | 0.741000 | 0.6770 | 2.08e-05 | 1.02e-04 |
| O2/CO2 exchange in erythrocytes | 11 | 3.19e-05 | 1.76e-04 | 1.0000 | 0.741000 | 0.6770 | 2.08e-05 | 1.02e-04 |
| Signaling by Interleukins | 385 | 1.98e-21 | 2.08e-19 | 0.3590 | 0.220000 | 0.2840 | 1.37e-13 | 1.03e-21 |
| Metabolism | 1758 | 1.90e-30 | 3.71e-28 | 0.1970 | 0.103000 | 0.1680 | 5.85e-13 | 1.29e-31 |
| Ub-specific processing proteases | 169 | 1.26e-05 | 7.92e-05 | 0.2570 | 0.147000 | 0.2110 | 1.01e-03 | 2.30e-06 |
| Viral mRNA Translation | 87 | 2.22e-04 | 9.81e-04 | 0.3130 | -0.187000 | -0.2510 | 2.55e-03 | 5.18e-05 |
| ESR-mediated signaling | 159 | 4.45e-08 | 5.78e-07 | 0.3300 | 0.200000 | 0.2630 | 1.36e-05 | 1.05e-08 |
| Synthesis of PC | 23 | 1.36e-02 | 3.26e-02 | 0.4420 | 0.280000 | 0.3420 | 2.01e-02 | 4.52e-03 |
| Signaling by TGFB family members | 91 | 4.35e-03 | 1.27e-02 | 0.2420 | 0.138000 | 0.1990 | 2.32e-02 | 1.03e-03 |
| Cellular responses to external stimuli | 503 | 9.71e-11 | 2.20e-09 | 0.2110 | 0.116000 | 0.1770 | 9.00e-06 | 1.18e-11 |
| Neurotransmitter receptors and postsynaptic signal transmission | 123 | 2.27e-03 | 7.21e-03 | 0.2180 | 0.121000 | 0.1820 | 2.02e-02 | 4.99e-04 |
| Ion channel transport | 133 | 5.02e-04 | 2.01e-03 | 0.2370 | 0.135000 | 0.1950 | 7.32e-03 | 1.05e-04 |
| Signaling by Leptin | 10 | 2.94e-03 | 9.09e-03 | 0.7890 | 0.587000 | 0.5270 | 1.31e-03 | 3.91e-03 |
| Cellular responses to stress | 497 | 3.56e-10 | 6.75e-09 | 0.2060 | 0.113000 | 0.1730 | 1.71e-05 | 4.43e-11 |
| Signaling by BRAF and RAF fusions | 57 | 9.29e-07 | 8.73e-06 | 0.5070 | 0.328000 | 0.3870 | 1.84e-05 | 4.28e-07 |
| M Phase | 359 | 4.01e-04 | 1.65e-03 | 0.1350 | 0.061800 | 0.1210 | 4.43e-02 | 8.77e-05 |
| Adaptive Immune System | 753 | 5.84e-05 | 3.03e-04 | 0.0947 | 0.031000 | 0.0895 | 1.48e-01 | 2.93e-05 |
| Peptide chain elongation | 87 | 6.28e-05 | 3.21e-04 | 0.3390 | -0.209000 | -0.2670 | 7.58e-04 | 1.68e-05 |
| ATF6 (ATF6-alpha) activates chaperones | 12 | 2.07e-02 | 4.49e-02 | 0.5850 | 0.442000 | 0.3850 | 8.08e-03 | 2.11e-02 |
| Selenocysteine synthesis | 91 | 1.36e-05 | 8.41e-05 | 0.3580 | -0.223000 | -0.2800 | 2.39e-04 | 3.94e-06 |
| ADP signalling through P2Y purinoceptor 1 | 21 | 9.98e-04 | 3.65e-03 | 0.5910 | 0.445000 | 0.3900 | 4.16e-04 | 1.99e-03 |
| Disorders of transmembrane transporters | 144 | 1.02e-03 | 3.71e-03 | 0.2170 | 0.123000 | 0.1780 | 1.07e-02 | 2.20e-04 |
| Interleukin-10 signaling | 35 | 3.16e-03 | 9.71e-03 | 0.4150 | 0.320000 | 0.2650 | 1.06e-03 | 6.63e-03 |
| Signaling by GPCR | 534 | 1.93e-03 | 6.43e-03 | 0.0909 | 0.031300 | 0.0853 | 2.17e-01 | 7.46e-04 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 36 | 3.64e-03 | 1.10e-02 | 0.4040 | 0.312000 | 0.2580 | 1.21e-03 | 7.43e-03 |
| Disease | 1339 | 2.21e-19 | 2.01e-17 | 0.1790 | 0.097100 | 0.1510 | 2.52e-09 | 1.99e-20 |
| Influenza Viral RNA Transcription and Replication | 134 | 2.59e-04 | 1.13e-03 | 0.2500 | -0.148000 | -0.2010 | 3.09e-03 | 5.90e-05 |
| Eukaryotic Translation Elongation | 92 | 7.43e-05 | 3.74e-04 | 0.3280 | -0.204000 | -0.2560 | 7.33e-04 | 2.12e-05 |
| Immune System | 1885 | 2.77e-52 | 1.26e-49 | 0.2640 | 0.158000 | 0.2110 | 4.26e-30 | 4.62e-52 |
| Glucagon signaling in metabolic regulation | 27 | 4.50e-03 | 1.31e-02 | 0.4600 | 0.298000 | 0.3500 | 7.36e-03 | 1.64e-03 |
| MAPK6/MAPK4 signaling | 82 | 3.09e-05 | 1.73e-04 | 0.3640 | 0.230000 | 0.2820 | 3.14e-04 | 1.00e-05 |
| GPCR downstream signalling | 489 | 4.18e-03 | 1.24e-02 | 0.0911 | 0.034100 | 0.0844 | 1.96e-01 | 1.39e-03 |
| Regulation of TLR by endogenous ligand | 11 | 1.12e-05 | 7.28e-05 | 1.0500 | 0.770000 | 0.7200 | 9.70e-06 | 3.51e-05 |
| Cytokine Signaling in Immune system | 733 | 2.08e-08 | 2.95e-07 | 0.1520 | 0.079500 | 0.1290 | 2.46e-04 | 2.71e-09 |
| Thrombin signalling through proteinase activated receptors (PARs) | 27 | 2.29e-03 | 7.24e-03 | 0.4890 | 0.320000 | 0.3690 | 4.00e-03 | 8.92e-04 |
| Signaling by ERBB4 | 44 | 1.61e-02 | 3.71e-02 | 0.3120 | 0.195000 | 0.2440 | 2.53e-02 | 5.15e-03 |
| Innate Immune System | 963 | 6.13e-91 | 4.18e-88 | 0.4870 | 0.319000 | 0.3680 | 1.70e-63 | 7.54e-84 |
| Neuronal System | 253 | 4.30e-03 | 1.26e-02 | 0.1410 | 0.073000 | 0.1210 | 4.56e-02 | 9.62e-04 |
| Interferon Signaling | 177 | 1.99e-03 | 6.59e-03 | 0.1860 | -0.153000 | -0.1050 | 4.45e-04 | 1.55e-02 |
| GRB2 events in EGFR signaling | 10 | 1.35e-02 | 3.26e-02 | 0.6780 | 0.502000 | 0.4560 | 5.98e-03 | 1.25e-02 |
| Eukaryotic Translation Termination | 91 | 1.20e-04 | 5.68e-04 | 0.3230 | -0.205000 | -0.2490 | 7.40e-04 | 3.93e-05 |
| Oxidative Stress Induced Senescence | 79 | 3.32e-05 | 1.80e-04 | 0.3710 | 0.240000 | 0.2840 | 2.31e-04 | 1.29e-05 |
| Costimulation by the CD28 family | 74 | 7.37e-04 | 2.86e-03 | 0.3200 | -0.247000 | -0.2030 | 2.39e-04 | 2.53e-03 |
| Transport of small molecules | 554 | 6.00e-15 | 3.03e-13 | 0.2500 | 0.154000 | 0.1960 | 5.35e-10 | 2.54e-15 |
| Mitochondrial biogenesis | 88 | 7.30e-03 | 1.97e-02 | 0.2400 | 0.147000 | 0.1890 | 1.69e-02 | 2.12e-03 |
| IRAK4 deficiency (TLR2/4) | 10 | 8.78e-07 | 8.31e-06 | 1.2200 | 0.845000 | 0.8860 | 3.74e-06 | 1.20e-06 |
| MyD88 deficiency (TLR2/4) | 10 | 8.78e-07 | 8.31e-06 | 1.2200 | 0.845000 | 0.8860 | 3.74e-06 | 1.20e-06 |
| Iron uptake and transport | 52 | 2.37e-06 | 1.95e-05 | 0.5160 | 0.385000 | 0.3430 | 1.57e-06 | 1.84e-05 |
| Signal amplification | 28 | 3.40e-05 | 1.84e-04 | 0.6270 | 0.464000 | 0.4220 | 2.16e-05 | 1.09e-04 |
| tRNA processing | 136 | 2.02e-04 | 9.01e-04 | 0.2560 | -0.161000 | -0.1990 | 1.22e-03 | 6.13e-05 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 26 | 2.03e-02 | 4.43e-02 | 0.3990 | 0.263000 | 0.3000 | 2.03e-02 | 8.02e-03 |
| Influenza Infection | 153 | 3.42e-03 | 1.04e-02 | 0.1950 | -0.118000 | -0.1550 | 1.17e-02 | 9.20e-04 |
| SHC1 events in EGFR signaling | 11 | 1.54e-02 | 3.56e-02 | 0.6380 | 0.432000 | 0.4690 | 1.30e-02 | 7.07e-03 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 12 | 1.45e-02 | 3.43e-02 | 0.6150 | 0.416000 | 0.4530 | 1.26e-02 | 6.64e-03 |
| Diseases of hemostasis | 12 | 1.45e-02 | 3.43e-02 | 0.6150 | 0.416000 | 0.4530 | 1.26e-02 | 6.64e-03 |
| Transferrin endocytosis and recycling | 26 | 1.93e-05 | 1.16e-04 | 0.6700 | 0.457000 | 0.4890 | 5.48e-05 | 1.56e-05 |
| ROS and RNS production in phagocytes | 31 | 1.32e-08 | 1.96e-07 | 0.7930 | 0.577000 | 0.5450 | 2.73e-08 | 1.53e-07 |
| Activation of GABAB receptors | 31 | 1.46e-02 | 3.44e-02 | 0.3810 | 0.253000 | 0.2850 | 1.47e-02 | 6.03e-03 |
| GABA B receptor activation | 31 | 1.46e-02 | 3.44e-02 | 0.3810 | 0.253000 | 0.2850 | 1.47e-02 | 6.03e-03 |
| Sphingolipid de novo biosynthesis | 42 | 1.86e-02 | 4.11e-02 | 0.3180 | 0.208000 | 0.2400 | 1.96e-02 | 7.17e-03 |
| Infectious disease | 773 | 2.73e-10 | 5.39e-09 | 0.1740 | 0.106000 | 0.1380 | 5.11e-07 | 7.52e-11 |
| G alpha (i) signalling events | 243 | 1.93e-02 | 4.27e-02 | 0.1270 | 0.073800 | 0.1040 | 4.75e-02 | 5.28e-03 |
| HCMV Infection | 96 | 4.71e-03 | 1.36e-02 | 0.2430 | 0.156000 | 0.1860 | 8.23e-03 | 1.64e-03 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 36 | 8.78e-03 | 2.28e-02 | 0.3750 | 0.250000 | 0.2790 | 9.50e-03 | 3.71e-03 |
| Extracellular matrix organization | 215 | 1.18e-05 | 7.47e-05 | 0.2370 | 0.152000 | 0.1810 | 1.22e-04 | 4.54e-06 |
| EPHB-mediated forward signaling | 32 | 4.26e-07 | 4.63e-06 | 0.7020 | 0.482000 | 0.5110 | 2.40e-06 | 5.70e-07 |
| RNA Polymerase II Transcription | 1197 | 1.43e-04 | 6.59e-04 | 0.0847 | -0.072300 | -0.0441 | 2.57e-05 | 1.03e-02 |
| HCMV Late Events | 69 | 1.32e-02 | 3.18e-02 | 0.2580 | 0.168000 | 0.1960 | 1.57e-02 | 4.94e-03 |
| Transmission across Chemical Synapses | 170 | 3.63e-03 | 1.10e-02 | 0.1860 | 0.117000 | 0.1450 | 8.33e-03 | 1.14e-03 |
| TNFR2 non-canonical NF-kB pathway | 95 | 1.16e-02 | 2.87e-02 | 0.2230 | 0.170000 | 0.1430 | 4.10e-03 | 1.59e-02 |
| Generic Transcription Pathway | 1078 | 4.82e-06 | 3.46e-05 | 0.1080 | -0.088800 | -0.0619 | 8.57e-07 | 6.01e-04 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 113 | 4.86e-03 | 1.39e-02 | 0.2230 | -0.144000 | -0.1710 | 8.12e-03 | 1.72e-03 |
| Nonsense-Mediated Decay (NMD) | 113 | 4.86e-03 | 1.39e-02 | 0.2230 | -0.144000 | -0.1710 | 8.12e-03 | 1.72e-03 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 32 | 7.60e-03 | 2.03e-02 | 0.4040 | 0.299000 | 0.2720 | 3.47e-03 | 7.65e-03 |
| GABA receptor activation | 36 | 1.27e-02 | 3.10e-02 | 0.3600 | 0.242000 | 0.2670 | 1.19e-02 | 5.60e-03 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 51 | 1.69e-04 | 7.70e-04 | 0.4280 | 0.314000 | 0.2900 | 1.04e-04 | 3.36e-04 |
| Phosphorylation of CD3 and TCR zeta chains | 27 | 2.11e-07 | 2.39e-06 | 0.7830 | -0.564000 | -0.5420 | 3.81e-07 | 1.07e-06 |
| Extension of Telomeres | 51 | 1.76e-03 | 5.98e-03 | 0.3650 | -0.247000 | -0.2690 | 2.25e-03 | 8.90e-04 |
| Extra-nuclear estrogen signaling | 65 | 9.00e-04 | 3.41e-03 | 0.3400 | 0.251000 | 0.2300 | 4.77e-04 | 1.31e-03 |
| Integrin cell surface interactions | 52 | 1.56e-02 | 3.61e-02 | 0.2930 | 0.217000 | 0.1970 | 6.86e-03 | 1.41e-02 |
| Interleukin-12 signaling | 44 | 1.99e-02 | 4.36e-02 | 0.3090 | 0.208000 | 0.2280 | 1.68e-02 | 8.81e-03 |
| Fanconi Anemia Pathway | 36 | 1.41e-03 | 4.92e-03 | 0.4430 | -0.323000 | -0.3030 | 8.11e-04 | 1.64e-03 |
| Aquaporin-mediated transport | 38 | 2.08e-03 | 6.89e-03 | 0.4180 | 0.305000 | 0.2860 | 1.16e-03 | 2.26e-03 |
| Growth hormone receptor signaling | 20 | 6.20e-03 | 1.71e-02 | 0.5230 | 0.361000 | 0.3780 | 5.17e-03 | 3.41e-03 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 55 | 2.29e-02 | 4.89e-02 | 0.2710 | 0.183000 | 0.2000 | 1.87e-02 | 1.02e-02 |
| Hemostasis | 542 | 1.80e-22 | 2.45e-20 | 0.3190 | 0.217000 | 0.2330 | 4.53e-18 | 1.78e-20 |
| Insulin receptor recycling | 21 | 1.06e-05 | 7.03e-05 | 0.7660 | 0.535000 | 0.5490 | 2.22e-05 | 1.32e-05 |
| p130Cas linkage to MAPK signaling for integrins | 11 | 2.21e-04 | 9.81e-04 | 0.9080 | 0.649000 | 0.6350 | 1.94e-04 | 2.66e-04 |
| Formation of Fibrin Clot (Clotting Cascade) | 26 | 1.16e-02 | 2.87e-02 | 0.4300 | 0.311000 | 0.2970 | 6.12e-03 | 8.80e-03 |
| Unwinding of DNA | 12 | 4.41e-04 | 1.81e-03 | 0.8330 | -0.582000 | -0.5950 | 4.80e-04 | 3.55e-04 |
| Gene expression (Transcription) | 1325 | 3.15e-05 | 1.76e-04 | 0.0934 | -0.072000 | -0.0595 | 1.09e-05 | 2.77e-04 |
| Resolution of Abasic Sites (AP sites) | 37 | 3.27e-03 | 1.00e-02 | 0.4080 | -0.283000 | -0.2940 | 2.90e-03 | 1.95e-03 |
| Selective autophagy | 57 | 5.52e-03 | 1.55e-02 | 0.3140 | 0.216000 | 0.2270 | 4.70e-03 | 3.05e-03 |
| Glycerophospholipid biosynthesis | 106 | 1.39e-05 | 8.60e-05 | 0.3380 | 0.234000 | 0.2430 | 3.09e-05 | 1.52e-05 |
| Signaling by SCF-KIT | 40 | 6.99e-03 | 1.90e-02 | 0.3660 | 0.254000 | 0.2630 | 5.39e-03 | 4.02e-03 |
| mTORC1-mediated signalling | 24 | 1.23e-03 | 4.36e-03 | 0.5490 | 0.384000 | 0.3920 | 1.13e-03 | 8.90e-04 |
| Regulation of insulin secretion | 60 | 7.52e-04 | 2.91e-03 | 0.3600 | 0.251000 | 0.2580 | 7.80e-04 | 5.51e-04 |
| Signaling by Insulin receptor | 59 | 1.25e-04 | 5.86e-04 | 0.4060 | 0.284000 | 0.2900 | 1.62e-04 | 1.19e-04 |
| Stimuli-sensing channels | 72 | 1.99e-02 | 4.36e-02 | 0.2420 | 0.174000 | 0.1680 | 1.06e-02 | 1.35e-02 |
| MET promotes cell motility | 26 | 1.78e-02 | 3.98e-02 | 0.4090 | 0.286000 | 0.2920 | 1.15e-02 | 1.01e-02 |
| Interleukin-12 family signaling | 53 | 1.12e-02 | 2.79e-02 | 0.3020 | 0.212000 | 0.2160 | 7.53e-03 | 6.64e-03 |
| Vasopressin regulates renal water homeostasis via Aquaporins | 34 | 4.56e-03 | 1.32e-02 | 0.4130 | 0.294000 | 0.2910 | 3.05e-03 | 3.30e-03 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 30 | 3.38e-04 | 1.43e-03 | 0.5360 | 0.380000 | 0.3780 | 3.17e-04 | 3.37e-04 |
| Dissolution of Fibrin Clot | 12 | 1.84e-03 | 6.22e-03 | 0.7520 | 0.531000 | 0.5330 | 1.45e-03 | 1.40e-03 |
| Transcriptional regulation of granulopoiesis | 46 | 9.38e-07 | 8.75e-06 | 0.5710 | 0.403000 | 0.4040 | 2.21e-06 | 2.18e-06 |
Detailed Gene set reports
CD22 mediated BCR regulation
| metric | value |
|---|---|
| setSize | 58 |
| pMANOVA | 1.55e-15 |
| p.adjustMANOVA | 9.58e-14 |
| s.dist | 0.4 |
| s.low.CRP | 0.197 |
| s.high.CRP | -0.348 |
| p.low.CRP | 0.00956 |
| p.high.CRP | 4.59e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGHV3-48 | 3183 | -4340 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CD22 | -3032 | -4243 |
| CD79A | -3264 | -4267 |
| CD79B | -6240 | -6157 |
| IGHD | -2028 | -4193 |
| IGHM | 1890 | -2470 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| LYN | 7575 | 8379 |
| PTPN6 | -691 | 7862 |
VLDLR internalisation and degradation
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000128 |
| p.adjustMANOVA | 6e-04 |
| s.dist | 0.642 |
| s.low.CRP | 0.0954 |
| s.high.CRP | 0.635 |
| p.low.CRP | 0.584 |
| p.high.CRP | 0.000266 |
| Gene | low CRP | high CRP |
|---|---|---|
| CLTC | 9376 | 9720 |
| CLTA | 8416 | 8998 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| NR1H2 | 4003 | 8448 |
| AP2A2 | 3196 | 9217 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -3194 | 9104 |
| AP2A2 | 3196 | 9217 |
| AP2B1 | -9145 | 2444 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| CLTA | 8416 | 8998 |
| CLTC | 9376 | 9720 |
| MYLIP | -4440 | -1671 |
| NR1H2 | 4003 | 8448 |
| NR1H3 | -8939 | 2196 |
| VLDLR | -9564 | 1877 |
Scavenging of heme from plasma
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 2.16e-17 |
| p.adjustMANOVA | 1.73e-15 |
| s.dist | 0.376 |
| s.low.CRP | 0.25 |
| s.high.CRP | -0.28 |
| p.low.CRP | 0.000292 |
| p.high.CRP | 5.05e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| JCHAIN | 4874 | -8700 |
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGHA1 | 4926 | -5918 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ALB | 1254 | 3551 |
| APOL1 | -7427 | -4732 |
| CD163 | 10038 | 10038 |
| HBA1 | 10009 | 8734 |
| HBB | 10013 | 8750 |
| HP | 9925 | 10000 |
| HPX | 477 | -1968 |
| IGHA1 | 4926 | -5918 |
| IGHA2 | 2335 | -2345 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| JCHAIN | 4874 | -8700 |
| LRP1 | 9226 | 9878 |
Classical antibody-mediated complement activation
| metric | value |
|---|---|
| setSize | 68 |
| pMANOVA | 7.31e-15 |
| p.adjustMANOVA | 3.56e-13 |
| s.dist | 0.366 |
| s.low.CRP | 0.161 |
| s.high.CRP | -0.328 |
| p.low.CRP | 0.0216 |
| p.high.CRP | 2.87e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| IGKV4-1 | 2812 | -4988 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | -49 | 7890 |
| C1QB | 6746 | 8930 |
| C1QC | 7805 | 9340 |
| C1R | -10393 | -4020 |
| C1S | -6159 | 552 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
Creation of C4 and C2 activators
| metric | value |
|---|---|
| setSize | 70 |
| pMANOVA | 4.1e-15 |
| p.adjustMANOVA | 2.43e-13 |
| s.dist | 0.359 |
| s.low.CRP | 0.174 |
| s.high.CRP | -0.314 |
| p.low.CRP | 0.0118 |
| p.high.CRP | 5.41e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| MASP2 | 2089 | -6883 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | -49 | 7890 |
| C1QB | 6746 | 8930 |
| C1QC | 7805 | 9340 |
| C1R | -10393 | -4020 |
| C1S | -6159 | 552 |
| FCN1 | 9889 | 9103 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| MASP2 | 2089 | -6883 |
Pre-NOTCH Processing in Golgi
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 2.8e-05 |
| p.adjustMANOVA | 0.000161 |
| s.dist | 0.522 |
| s.low.CRP | 0.0479 |
| s.high.CRP | 0.519 |
| p.low.CRP | 0.725 |
| p.high.CRP | 0.000136 |
| Gene | low CRP | high CRP |
|---|---|---|
| FURIN | 8111 | 10053 |
| RAB6A | 8487 | 8616 |
| ATP2A2 | 8393 | 8341 |
| RFNG | 7041 | 8287 |
| SEL1L | 7157 | 7252 |
| ST3GAL6 | 9317 | 5155 |
| TMED2 | 6426 | 6360 |
| NOTCH2 | 4412 | 6414 |
| ST3GAL3 | 2775 | 828 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ATP2A1 | -4808 | -3244 |
| ATP2A2 | 8393 | 8341 |
| ATP2A3 | -9252 | 3112 |
| B4GALT1 | -4177 | 7099 |
| FURIN | 8111 | 10053 |
| LFNG | -9497 | -3283 |
| MFNG | -7860 | -990 |
| NOTCH1 | -6446 | 6708 |
| NOTCH2 | 4412 | 6414 |
| NOTCH3 | -744 | 9587 |
| NOTCH4 | -10586 | 1602 |
| RAB6A | 8487 | 8616 |
| RFNG | 7041 | 8287 |
| SEL1L | 7157 | 7252 |
| ST3GAL3 | 2775 | 828 |
| ST3GAL4 | -9921 | 7993 |
| ST3GAL6 | 9317 | 5155 |
| TMED2 | 6426 | 6360 |
tRNA processing in the mitochondrion
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 1.76e-07 |
| p.adjustMANOVA | 2.05e-06 |
| s.dist | 0.41 |
| s.low.CRP | -0.405 |
| s.high.CRP | 0.0665 |
| p.low.CRP | 7.36e-05 |
| p.high.CRP | 0.515 |
| Gene | low CRP | high CRP |
|---|---|---|
| MT-ATP8 | -8699 | 3719 |
| MT-TM | -9490 | 3091 |
| MT-TS1 | -9189 | 3187 |
| MT-TN | -10118 | 2887 |
| MT-TC | -9974 | 2498 |
| MT-TA | -9601 | 1837 |
| MT-ND4L | -6001 | 1900 |
| MT-ATP6 | -6161 | 1833 |
| MT-TL1 | -8729 | 1284 |
| MT-TF | -8605 | 1267 |
| MT-TY | -10274 | 1051 |
| MT-TV | -9270 | 940 |
| HSD17B10 | -1197 | 6037 |
| MT-CO2 | -1994 | 1965 |
| MT-CO3 | -1724 | 2140 |
| MT-RNR2 | -373 | 3642 |
| MT-RNR1 | -1023 | 1206 |
| MT-ND5 | -3288 | 283 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ELAC2 | -10756 | -5453 |
| HSD17B10 | -1197 | 6037 |
| MT-ATP6 | -6161 | 1833 |
| MT-ATP8 | -8699 | 3719 |
| MT-CO1 | 575 | 1906 |
| MT-CO2 | -1994 | 1965 |
| MT-CO3 | -1724 | 2140 |
| MT-CYB | -2748 | -78 |
| MT-ND1 | -3881 | -1394 |
| MT-ND2 | -6369 | -3767 |
| MT-ND3 | -4723 | -1060 |
| MT-ND4 | 1457 | 1379 |
| MT-ND4L | -6001 | 1900 |
| MT-ND5 | -3288 | 283 |
| MT-ND6 | 2811 | 366 |
| MT-RNR1 | -1023 | 1206 |
| MT-RNR2 | -373 | 3642 |
| MT-TA | -9601 | 1837 |
| MT-TC | -9974 | 2498 |
| MT-TE | -8792 | -2538 |
| MT-TF | -8605 | 1267 |
| MT-TL1 | -8729 | 1284 |
| MT-TL2 | -9294 | -2861 |
| MT-TM | -9490 | 3091 |
| MT-TN | -10118 | 2887 |
| MT-TP | -11154 | -11088 |
| MT-TS1 | -9189 | 3187 |
| MT-TV | -9270 | 940 |
| MT-TY | -10274 | 1051 |
| PRORP | 5623 | 3349 |
| TRMT10C | 4825 | -5987 |
| TRNT1 | 1209 | -8693 |
Role of LAT2/NTAL/LAB on calcium mobilization
| metric | value |
|---|---|
| setSize | 73 |
| pMANOVA | 4.31e-14 |
| p.adjustMANOVA | 1.78e-12 |
| s.dist | 0.329 |
| s.low.CRP | 0.23 |
| s.high.CRP | -0.236 |
| p.low.CRP | 0.000684 |
| p.high.CRP | 0.000498 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| SOS1 | 3534 | -7412 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| FYN | -10878 | -6729 |
| GAB2 | 7546 | 9347 |
| GRB2 | 9631 | 9985 |
| IGHE | -498 | -5753 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| LAT2 | 8582 | 9705 |
| LYN | 7575 | 8379 |
| PDPK1 | 2392 | 7816 |
| PIK3CA | 6889 | 4182 |
| PIK3CB | 9838 | 9248 |
| PIK3R1 | -7197 | -8942 |
| PIK3R2 | 2459 | 5820 |
| SHC1 | -3416 | 5815 |
| SOS1 | 3534 | -7412 |
| SYK | 9464 | 9848 |
Nucleobase biosynthesis
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00193 |
| p.adjustMANOVA | 0.00645 |
| s.dist | 0.418 |
| s.low.CRP | 0.0473 |
| s.high.CRP | -0.416 |
| p.low.CRP | 0.768 |
| p.high.CRP | 0.00946 |
| Gene | low CRP | high CRP |
|---|---|---|
| PAICS | 6998 | -9059 |
| DHODH | 42 | -5669 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ADSL | 8290 | 4286 |
| ATIC | -4273 | -10792 |
| CAD | -3235 | -8762 |
| DHODH | 42 | -5669 |
| GART | -2276 | -559 |
| GMPS | -352 | -3659 |
| IMPDH1 | 9819 | 9891 |
| IMPDH2 | -3563 | -10154 |
| LHPP | 2376 | 219 |
| PAICS | 6998 | -9059 |
| PFAS | -7982 | -10250 |
| PPAT | -2697 | -11066 |
| UMPS | -4083 | -9494 |
FCGR activation
| metric | value |
|---|---|
| setSize | 75 |
| pMANOVA | 3.32e-14 |
| p.adjustMANOVA | 1.43e-12 |
| s.dist | 0.342 |
| s.low.CRP | 0.143 |
| s.high.CRP | -0.311 |
| p.low.CRP | 0.0322 |
| p.high.CRP | 3.24e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| IGKV4-1 | 2812 | -4988 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CD247 | -11271 | -10327 |
| CD3G | -9054 | -10504 |
| FCGR1A | 9965 | 9575 |
| FCGR2A | 9414 | 9249 |
| FCGR3A | -11272 | -4672 |
| FGR | 6254 | 9666 |
| FYN | -10878 | -6729 |
| HCK | 9286 | 9494 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| LYN | 7575 | 8379 |
| SRC | -6857 | -7229 |
| SYK | 9464 | 9848 |
| YES1 | -11138 | -8566 |
Initial triggering of complement
| metric | value |
|---|---|
| setSize | 77 |
| pMANOVA | 3.37e-14 |
| p.adjustMANOVA | 1.43e-12 |
| s.dist | 0.332 |
| s.low.CRP | 0.158 |
| s.high.CRP | -0.292 |
| p.low.CRP | 0.0165 |
| p.high.CRP | 9.18e-06 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| MASP2 | 2089 | -6883 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | -49 | 7890 |
| C1QB | 6746 | 8930 |
| C1QC | 7805 | 9340 |
| C1R | -10393 | -4020 |
| C1S | -6159 | 552 |
| C2 | 6634 | 2959 |
| C3 | -11179 | -10489 |
| C4A | 5060 | 4740 |
| C4B | 6359 | 2884 |
| CFB | -3014 | -2968 |
| CFD | 2998 | 2390 |
| FCN1 | 9889 | 9103 |
| GZMM | -11118 | -8768 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| MASP2 | 2089 | -6883 |
Purine ribonucleoside monophosphate biosynthesis
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0167 |
| p.adjustMANOVA | 0.0381 |
| s.dist | 0.351 |
| s.low.CRP | 0.113 |
| s.high.CRP | -0.332 |
| p.low.CRP | 0.535 |
| p.high.CRP | 0.0688 |
| Gene | low CRP | high CRP |
|---|---|---|
| PAICS | 6998 | -9059 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ADSL | 8290 | 4286 |
| ATIC | -4273 | -10792 |
| GART | -2276 | -559 |
| GMPS | -352 | -3659 |
| IMPDH1 | 9819 | 9891 |
| IMPDH2 | -3563 | -10154 |
| LHPP | 2376 | 219 |
| PAICS | 6998 | -9059 |
| PFAS | -7982 | -10250 |
| PPAT | -2697 | -11066 |
N-Glycan antennae elongation
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00413 |
| p.adjustMANOVA | 0.0122 |
| s.dist | 0.383 |
| s.low.CRP | -0.378 |
| s.high.CRP | 0.0609 |
| p.low.CRP | 0.0182 |
| p.high.CRP | 0.704 |
| Gene | low CRP | high CRP |
|---|---|---|
| ST3GAL4 | -9921 | 7993 |
| B4GALT4 | -9971 | 3971 |
| B4GALT1 | -4177 | 7099 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| B4GALT1 | -4177 | 7099 |
| B4GALT2 | -7253 | -2349 |
| B4GALT3 | -9162 | -7981 |
| B4GALT4 | -9971 | 3971 |
| B4GALT5 | 8862 | 9469 |
| B4GALT6 | -10936 | -1047 |
| MGAT4A | -3305 | -4301 |
| MGAT4B | 9276 | 9187 |
| MGAT4C | 3599 | -4032 |
| MGAT5 | -5440 | -102 |
| ST3GAL4 | -9921 | 7993 |
| ST6GAL1 | -10673 | -10107 |
| ST8SIA6 | -10982 | -6606 |
Metabolism of amine-derived hormones
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.018 |
| p.adjustMANOVA | 0.0401 |
| s.dist | 0.38 |
| s.low.CRP | 0.0466 |
| s.high.CRP | -0.378 |
| p.low.CRP | 0.799 |
| p.high.CRP | 0.0387 |
| Gene | low CRP | high CRP |
|---|---|---|
| TPO | 7263 | -6039 |
| SLC5A5 | 4358 | -8309 |
| DIO1 | 4371 | -5489 |
| IYD | 6285 | -3433 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AANAT | -3281 | 1887 |
| DBH | -5056 | -10427 |
| DIO1 | 4371 | -5489 |
| DUOX1 | -9681 | -9527 |
| IYD | 6285 | -3433 |
| PNMT | -4884 | 1572 |
| SLC5A5 | 4358 | -8309 |
| TPH1 | -2180 | -9746 |
| TPH2 | 2016 | 3522 |
| TPO | 7263 | -6039 |
Binding and Uptake of Ligands by Scavenger Receptors
| metric | value |
|---|---|
| setSize | 91 |
| pMANOVA | 9.23e-15 |
| p.adjustMANOVA | 4.34e-13 |
| s.dist | 0.314 |
| s.low.CRP | 0.28 |
| s.high.CRP | -0.142 |
| p.low.CRP | 3.95e-06 |
| p.high.CRP | 0.019 |
| Gene | low CRP | high CRP |
|---|---|---|
| JCHAIN | 4874 | -8700 |
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGHA1 | 4926 | -5918 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ALB | 1254 | 3551 |
| APOE | -5022 | 1771 |
| APOL1 | -7427 | -4732 |
| CALR | 6685 | 6374 |
| CD163 | 10038 | 10038 |
| CD36 | 10064 | 9814 |
| COL1A2 | 5690 | 684 |
| COL4A2 | 1717 | 838 |
| COLEC12 | -5943 | -2495 |
| FTH1 | 3543 | 5337 |
| FTL | 8704 | 9324 |
| HBA1 | 10009 | 8734 |
| HBB | 10013 | 8750 |
| HP | 9925 | 10000 |
| HPX | 477 | -1968 |
| HSP90AA1 | 5309 | 410 |
| HSP90B1 | 7042 | 372 |
| HSPH1 | -1504 | -8662 |
| HYOU1 | -6582 | 2512 |
| IGHA1 | 4926 | -5918 |
| IGHA2 | 2335 | -2345 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| JCHAIN | 4874 | -8700 |
| LRP1 | 9226 | 9878 |
| MARCO | 6219 | 9851 |
| MSR1 | -528 | 1494 |
| SCARB1 | 7210 | 6035 |
| SCARF1 | 6500 | -1228 |
| SCGB3A2 | 718 | -1063 |
| SPARC | 9073 | 7195 |
| SSC5D | -3756 | -4645 |
| STAB1 | 10077 | 10111 |
| STAB2 | 7035 | 5388 |
Pausing and recovery of Tat-mediated HIV elongation
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 2e-05 |
| p.adjustMANOVA | 0.000119 |
| s.dist | 0.325 |
| s.low.CRP | -0.118 |
| s.high.CRP | 0.303 |
| p.low.CRP | 0.264 |
| p.high.CRP | 0.0041 |
| Gene | low CRP | high CRP |
|---|---|---|
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| NELFB | -8446 | 5056 |
| POLR2G | -5778 | 6576 |
| NELFE | -4877 | 6342 |
| ELL | -4094 | 6433 |
| POLR2A | -8726 | 2901 |
| GTF2F1 | -3109 | 7342 |
| SUPT4H1 | -3945 | 5159 |
| POLR2F | -2307 | 6746 |
| POLR2C | -2183 | 3527 |
| POLR2I | -2123 | 2695 |
| POLR2B | -1034 | 188 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CCNT1 | -8231 | -6368 |
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| ELL | -4094 | 6433 |
| ELOA | 8918 | 6756 |
| ELOB | 4867 | 8716 |
| ELOC | 6598 | 8484 |
| GTF2F1 | -3109 | 7342 |
| GTF2F2 | 4728 | 6017 |
| NELFA | -2921 | -970 |
| NELFB | -8446 | 5056 |
| NELFCD | -3646 | -4090 |
| NELFE | -4877 | 6342 |
| POLR2A | -8726 | 2901 |
| POLR2B | -1034 | 188 |
| POLR2C | -2183 | 3527 |
| POLR2D | 3401 | -4083 |
| POLR2E | 6766 | 8343 |
| POLR2F | -2307 | 6746 |
| POLR2G | -5778 | 6576 |
| POLR2H | 653 | -2264 |
| POLR2I | -2123 | 2695 |
| POLR2J | 4448 | 7822 |
| POLR2K | 1881 | -1885 |
| POLR2L | 126 | 7246 |
| SSRP1 | -9188 | -7998 |
| SUPT16H | -8035 | -9349 |
| SUPT4H1 | -3945 | 5159 |
| SUPT5H | -7894 | -1035 |
| TCEA1 | 5155 | -1614 |
Tat-mediated HIV elongation arrest and recovery
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 2e-05 |
| p.adjustMANOVA | 0.000119 |
| s.dist | 0.325 |
| s.low.CRP | -0.118 |
| s.high.CRP | 0.303 |
| p.low.CRP | 0.264 |
| p.high.CRP | 0.0041 |
| Gene | low CRP | high CRP |
|---|---|---|
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| NELFB | -8446 | 5056 |
| POLR2G | -5778 | 6576 |
| NELFE | -4877 | 6342 |
| ELL | -4094 | 6433 |
| POLR2A | -8726 | 2901 |
| GTF2F1 | -3109 | 7342 |
| SUPT4H1 | -3945 | 5159 |
| POLR2F | -2307 | 6746 |
| POLR2C | -2183 | 3527 |
| POLR2I | -2123 | 2695 |
| POLR2B | -1034 | 188 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CCNT1 | -8231 | -6368 |
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| ELL | -4094 | 6433 |
| ELOA | 8918 | 6756 |
| ELOB | 4867 | 8716 |
| ELOC | 6598 | 8484 |
| GTF2F1 | -3109 | 7342 |
| GTF2F2 | 4728 | 6017 |
| NELFA | -2921 | -970 |
| NELFB | -8446 | 5056 |
| NELFCD | -3646 | -4090 |
| NELFE | -4877 | 6342 |
| POLR2A | -8726 | 2901 |
| POLR2B | -1034 | 188 |
| POLR2C | -2183 | 3527 |
| POLR2D | 3401 | -4083 |
| POLR2E | 6766 | 8343 |
| POLR2F | -2307 | 6746 |
| POLR2G | -5778 | 6576 |
| POLR2H | 653 | -2264 |
| POLR2I | -2123 | 2695 |
| POLR2J | 4448 | 7822 |
| POLR2K | 1881 | -1885 |
| POLR2L | 126 | 7246 |
| SSRP1 | -9188 | -7998 |
| SUPT16H | -8035 | -9349 |
| SUPT4H1 | -3945 | 5159 |
| SUPT5H | -7894 | -1035 |
| TCEA1 | 5155 | -1614 |
Class C/3 (Metabotropic glutamate/pheromone receptors)
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.012 |
| p.adjustMANOVA | 0.0294 |
| s.dist | 0.398 |
| s.low.CRP | 0.0167 |
| s.high.CRP | -0.398 |
| p.low.CRP | 0.924 |
| p.high.CRP | 0.0223 |
| Gene | low CRP | high CRP |
|---|---|---|
| TAS2R5 | 2711 | -8268 |
| GABBR1 | 3026 | -4023 |
| TAS2R14 | 5608 | -1571 |
| TAS1R3 | 2681 | -2430 |
| TAS2R3 | 825 | -5793 |
| TAS2R20 | 441 | -5135 |
| TAS2R30 | 192 | -4431 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CASR | -8364 | -2828 |
| GABBR1 | 3026 | -4023 |
| GRM2 | -9939 | -9829 |
| GRM6 | -660 | -1013 |
| TAS1R3 | 2681 | -2430 |
| TAS2R14 | 5608 | -1571 |
| TAS2R20 | 441 | -5135 |
| TAS2R3 | 825 | -5793 |
| TAS2R30 | 192 | -4431 |
| TAS2R4 | -907 | -7649 |
| TAS2R5 | 2711 | -8268 |
Regulation of TP53 Activity through Acetylation
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 8.63e-06 |
| p.adjustMANOVA | 5.77e-05 |
| s.dist | 0.4 |
| s.low.CRP | -0.4 |
| s.high.CRP | 0.0133 |
| p.low.CRP | 0.000192 |
| p.high.CRP | 0.901 |
| Gene | low CRP | high CRP |
|---|---|---|
| AKT2 | -8391 | 5504 |
| GATAD2A | -6815 | 5314 |
| PIN1 | -9660 | 3728 |
| AKT1 | -4794 | 6231 |
| KAT6A | -7218 | 3582 |
| PIP4K2A | -8599 | 2837 |
| GATAD2B | -7514 | 2232 |
| HDAC1 | -3835 | 3708 |
| MTA2 | -10115 | 863 |
| BRPF1 | -10119 | 827 |
| CHD4 | -8254 | 587 |
| MBD3 | -247 | 1576 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AKT1 | -4794 | 6231 |
| AKT2 | -8391 | 5504 |
| AKT3 | -9616 | -10833 |
| BRD1 | -10170 | -5159 |
| BRD7 | 4663 | -340 |
| BRPF1 | -10119 | 827 |
| BRPF3 | -9358 | -1215 |
| CHD3 | -9446 | -6383 |
| CHD4 | -8254 | 587 |
| EP300 | 4311 | 7552 |
| GATAD2A | -6815 | 5314 |
| GATAD2B | -7514 | 2232 |
| HDAC1 | -3835 | 3708 |
| HDAC2 | 8973 | 3999 |
| ING2 | 5186 | 4738 |
| ING5 | -5547 | -10054 |
| KAT6A | -7218 | 3582 |
| MAP2K6 | 9435 | 9577 |
| MBD3 | -247 | 1576 |
| MEAF6 | -4622 | -5583 |
| MTA2 | -10115 | 863 |
| PIN1 | -9660 | 3728 |
| PIP4K2A | -8599 | 2837 |
| PIP4K2B | -7642 | -3179 |
| PIP4K2C | -10764 | -5694 |
| PML | -6449 | -6720 |
| RBBP4 | 4016 | -1020 |
| RBBP7 | -10846 | -9848 |
| TP53 | -7284 | -8934 |
ERKs are inactivated
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00109 |
| p.adjustMANOVA | 0.00394 |
| s.dist | 0.545 |
| s.low.CRP | 0.121 |
| s.high.CRP | 0.531 |
| p.low.CRP | 0.449 |
| p.high.CRP | 0.000915 |
| Gene | low CRP | high CRP |
|---|---|---|
| DUSP3 | 9937 | 9647 |
| MAPK3 | 8931 | 9626 |
| PPP2CA | 8810 | 8328 |
| PPP2CB | 8482 | 7631 |
| DUSP6 | 7994 | 2589 |
| MAPK1 | 1052 | 9260 |
| PPP2R1B | 2503 | 437 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| DUSP3 | 9937 | 9647 |
| DUSP4 | -6630 | -4192 |
| DUSP6 | 7994 | 2589 |
| DUSP7 | -4748 | 387 |
| MAPK1 | 1052 | 9260 |
| MAPK3 | 8931 | 9626 |
| MAPK7 | -10125 | 5069 |
| PPP2CA | 8810 | 8328 |
| PPP2CB | 8482 | 7631 |
| PPP2R1A | -3087 | 6994 |
| PPP2R1B | 2503 | 437 |
| PPP2R5D | -6508 | 4985 |
| VRK3 | -7245 | 5798 |
Endosomal/Vacuolar pathway
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0128 |
| p.adjustMANOVA | 0.0311 |
| s.dist | 0.365 |
| s.low.CRP | -0.363 |
| s.high.CRP | 0.0386 |
| p.low.CRP | 0.0295 |
| p.high.CRP | 0.817 |
| Gene | low CRP | high CRP |
|---|---|---|
| CTSL | -5538 | 5895 |
| HLA-E | -10409 | 2003 |
| HLA-C | -2829 | 2125 |
| HLA-H | -8161 | 452 |
| HLA-A | -5067 | 570 |
| HLA-B | -1559 | 1570 |
| HLA-G | -5051 | 159 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| B2M | -4257 | -4660 |
| CTSL | -5538 | 5895 |
| CTSS | 9854 | 7280 |
| CTSV | -1271 | -2930 |
| HLA-A | -5067 | 570 |
| HLA-B | -1559 | 1570 |
| HLA-C | -2829 | 2125 |
| HLA-E | -10409 | 2003 |
| HLA-F | -10598 | -7440 |
| HLA-G | -5051 | 159 |
| HLA-H | -8161 | 452 |
| LNPEP | -8634 | -6784 |
HIV elongation arrest and recovery
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 2.99e-05 |
| p.adjustMANOVA | 0.000168 |
| s.dist | 0.308 |
| s.low.CRP | -0.115 |
| s.high.CRP | 0.285 |
| p.low.CRP | 0.259 |
| p.high.CRP | 0.00525 |
| Gene | low CRP | high CRP |
|---|---|---|
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| NELFB | -8446 | 5056 |
| POLR2G | -5778 | 6576 |
| NELFE | -4877 | 6342 |
| ELL | -4094 | 6433 |
| POLR2A | -8726 | 2901 |
| GTF2F1 | -3109 | 7342 |
| SUPT4H1 | -3945 | 5159 |
| POLR2F | -2307 | 6746 |
| CCNK | -3547 | 4337 |
| POLR2C | -2183 | 3527 |
| POLR2I | -2123 | 2695 |
| POLR2B | -1034 | 188 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CCNK | -3547 | 4337 |
| CCNT1 | -8231 | -6368 |
| CCNT2 | 770 | -5045 |
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| ELL | -4094 | 6433 |
| ELOA | 8918 | 6756 |
| ELOB | 4867 | 8716 |
| ELOC | 6598 | 8484 |
| GTF2F1 | -3109 | 7342 |
| GTF2F2 | 4728 | 6017 |
| NELFA | -2921 | -970 |
| NELFB | -8446 | 5056 |
| NELFCD | -3646 | -4090 |
| NELFE | -4877 | 6342 |
| POLR2A | -8726 | 2901 |
| POLR2B | -1034 | 188 |
| POLR2C | -2183 | 3527 |
| POLR2D | 3401 | -4083 |
| POLR2E | 6766 | 8343 |
| POLR2F | -2307 | 6746 |
| POLR2G | -5778 | 6576 |
| POLR2H | 653 | -2264 |
| POLR2I | -2123 | 2695 |
| POLR2J | 4448 | 7822 |
| POLR2K | 1881 | -1885 |
| POLR2L | 126 | 7246 |
| SSRP1 | -9188 | -7998 |
| SUPT16H | -8035 | -9349 |
| SUPT4H1 | -3945 | 5159 |
| SUPT5H | -7894 | -1035 |
| TCEA1 | 5155 | -1614 |
Pausing and recovery of HIV elongation
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 2.99e-05 |
| p.adjustMANOVA | 0.000168 |
| s.dist | 0.308 |
| s.low.CRP | -0.115 |
| s.high.CRP | 0.285 |
| p.low.CRP | 0.259 |
| p.high.CRP | 0.00525 |
| Gene | low CRP | high CRP |
|---|---|---|
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| NELFB | -8446 | 5056 |
| POLR2G | -5778 | 6576 |
| NELFE | -4877 | 6342 |
| ELL | -4094 | 6433 |
| POLR2A | -8726 | 2901 |
| GTF2F1 | -3109 | 7342 |
| SUPT4H1 | -3945 | 5159 |
| POLR2F | -2307 | 6746 |
| CCNK | -3547 | 4337 |
| POLR2C | -2183 | 3527 |
| POLR2I | -2123 | 2695 |
| POLR2B | -1034 | 188 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CCNK | -3547 | 4337 |
| CCNT1 | -8231 | -6368 |
| CCNT2 | 770 | -5045 |
| CDK9 | -10657 | 5444 |
| CTDP1 | -5483 | 8151 |
| ELL | -4094 | 6433 |
| ELOA | 8918 | 6756 |
| ELOB | 4867 | 8716 |
| ELOC | 6598 | 8484 |
| GTF2F1 | -3109 | 7342 |
| GTF2F2 | 4728 | 6017 |
| NELFA | -2921 | -970 |
| NELFB | -8446 | 5056 |
| NELFCD | -3646 | -4090 |
| NELFE | -4877 | 6342 |
| POLR2A | -8726 | 2901 |
| POLR2B | -1034 | 188 |
| POLR2C | -2183 | 3527 |
| POLR2D | 3401 | -4083 |
| POLR2E | 6766 | 8343 |
| POLR2F | -2307 | 6746 |
| POLR2G | -5778 | 6576 |
| POLR2H | 653 | -2264 |
| POLR2I | -2123 | 2695 |
| POLR2J | 4448 | 7822 |
| POLR2K | 1881 | -1885 |
| POLR2L | 126 | 7246 |
| SSRP1 | -9188 | -7998 |
| SUPT16H | -8035 | -9349 |
| SUPT4H1 | -3945 | 5159 |
| SUPT5H | -7894 | -1035 |
| TCEA1 | 5155 | -1614 |
Role of phospholipids in phagocytosis
| metric | value |
|---|---|
| setSize | 87 |
| pMANOVA | 3.18e-12 |
| p.adjustMANOVA | 9.22e-11 |
| s.dist | 0.29 |
| s.low.CRP | 0.135 |
| s.high.CRP | -0.257 |
| p.low.CRP | 0.0301 |
| p.high.CRP | 3.51e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| IGKV4-1 | 2812 | -4988 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AHCYL1 | 6114 | 7566 |
| CD247 | -11271 | -10327 |
| CD3G | -9054 | -10504 |
| FCGR1A | 9965 | 9575 |
| FCGR2A | 9414 | 9249 |
| FCGR3A | -11272 | -4672 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| ITPR1 | -5546 | -5368 |
| ITPR2 | 6833 | 6418 |
| ITPR3 | -8438 | -9066 |
| PIK3CA | 6889 | 4182 |
| PIK3CB | 9838 | 9248 |
| PIK3R1 | -7197 | -8942 |
| PIK3R2 | 2459 | 5820 |
| PLA2G6 | -10753 | -10993 |
| PLCG1 | -6360 | -11043 |
| PLCG2 | -4618 | 6826 |
| PLD1 | 9826 | 9945 |
| PLD2 | 7087 | 7779 |
| PLD3 | 8640 | 7098 |
| PLD4 | -11266 | -11216 |
| PLPP5 | -4861 | -6194 |
| PRKCD | 9393 | 9642 |
| PRKCE | -10383 | -2720 |
| SYK | 9464 | 9848 |
WNT5A-dependent internalization of FZD4
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.000968 |
| p.adjustMANOVA | 0.00358 |
| s.dist | 0.578 |
| s.low.CRP | 0.165 |
| s.high.CRP | 0.554 |
| p.low.CRP | 0.302 |
| p.high.CRP | 0.000546 |
| Gene | low CRP | high CRP |
|---|---|---|
| CLTC | 9376 | 9720 |
| CLTA | 8416 | 8998 |
| ARRB2 | 7827 | 9274 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| PRKCB | 5395 | 8378 |
| AP2A2 | 3196 | 9217 |
| PRKCA | 2473 | 1229 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -3194 | 9104 |
| AP2A2 | 3196 | 9217 |
| AP2B1 | -9145 | 2444 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| ARRB2 | 7827 | 9274 |
| CLTA | 8416 | 8998 |
| CLTB | -2857 | 8274 |
| CLTC | 9376 | 9720 |
| DVL2 | -10305 | -7147 |
| FZD4 | -10858 | -7985 |
| PRKCA | 2473 | 1229 |
| PRKCB | 5395 | 8378 |
Regulation of Complement cascade
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 1.56e-12 |
| p.adjustMANOVA | 4.61e-11 |
| s.dist | 0.274 |
| s.low.CRP | 0.203 |
| s.high.CRP | -0.185 |
| p.low.CRP | 0.00071 |
| p.high.CRP | 0.00209 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| C4BPB | 3624 | -4862 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | -49 | 7890 |
| C1QB | 6746 | 8930 |
| C1QC | 7805 | 9340 |
| C1R | -10393 | -4020 |
| C1S | -6159 | 552 |
| C2 | 6634 | 2959 |
| C3 | -11179 | -10489 |
| C3AR1 | 8924 | 8181 |
| C4A | 5060 | 4740 |
| C4B | 6359 | 2884 |
| C4BPB | 3624 | -4862 |
| C5 | 7727 | 2354 |
| C5AR1 | 9359 | 9709 |
| C5AR2 | 8198 | 8666 |
| C8G | -10839 | -8035 |
| CD19 | -2992 | -2929 |
| CD46 | 8744 | 5145 |
| CD55 | 9326 | 9842 |
| CD59 | 4075 | 5772 |
| CD81 | -10685 | -3573 |
| CFB | -3014 | -2968 |
| CFH | -3147 | -6338 |
| CLU | 9512 | 10102 |
| CPN2 | 8266 | 1159 |
| CR1 | 10079 | 10078 |
| CR2 | -1342 | -3900 |
| ELANE | 9880 | 4888 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| PROS1 | 9065 | 7937 |
| SERPING1 | -6329 | -10968 |
| VTN | -5291 | 730 |
Complement cascade
| metric | value |
|---|---|
| setSize | 97 |
| pMANOVA | 1.56e-12 |
| p.adjustMANOVA | 4.61e-11 |
| s.dist | 0.269 |
| s.low.CRP | 0.201 |
| s.high.CRP | -0.179 |
| p.low.CRP | 0.000633 |
| p.high.CRP | 0.00233 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| C4BPB | 3624 | -4862 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| C1QA | -49 | 7890 |
| C1QB | 6746 | 8930 |
| C1QC | 7805 | 9340 |
| C1R | -10393 | -4020 |
| C1S | -6159 | 552 |
| C2 | 6634 | 2959 |
| C3 | -11179 | -10489 |
| C3AR1 | 8924 | 8181 |
| C4A | 5060 | 4740 |
| C4B | 6359 | 2884 |
| C4BPB | 3624 | -4862 |
| C5 | 7727 | 2354 |
| C5AR1 | 9359 | 9709 |
| C5AR2 | 8198 | 8666 |
| C8G | -10839 | -8035 |
| CD19 | -2992 | -2929 |
| CD46 | 8744 | 5145 |
| CD55 | 9326 | 9842 |
| CD59 | 4075 | 5772 |
| CD81 | -10685 | -3573 |
| CFB | -3014 | -2968 |
| CFD | 2998 | 2390 |
| CFH | -3147 | -6338 |
| CLU | 9512 | 10102 |
| CPN2 | 8266 | 1159 |
| CR1 | 10079 | 10078 |
| CR2 | -1342 | -3900 |
| ELANE | 9880 | 4888 |
| FCN1 | 9889 | 9103 |
| GZMM | -11118 | -8768 |
| IGHG1 | -1124 | -7111 |
| IGHG2 | -5587 | -6004 |
| IGHG3 | -507 | -4089 |
| IGHG4 | -4038 | -5940 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| MASP2 | 2089 | -6883 |
| PROS1 | 9065 | 7937 |
| SERPING1 | -6329 | -10968 |
| VTN | -5291 | 730 |
HDMs demethylate histones
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 0.00145 |
| p.adjustMANOVA | 0.00503 |
| s.dist | 0.325 |
| s.low.CRP | -0.0444 |
| s.high.CRP | 0.322 |
| p.low.CRP | 0.719 |
| p.high.CRP | 0.00896 |
| Gene | low CRP | high CRP |
|---|---|---|
| KDM5C | -4837 | 6795 |
| PHF8 | -6137 | 4275 |
| KDM4A | -5855 | 4280 |
| KDM6A | -3419 | 5092 |
| KDM2A | -2499 | 5906 |
| KDM5B | -1367 | 7624 |
| KDM5A | -6036 | 1492 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARID5B | 802.0 | 34.0 |
| H3C15 | 5262.5 | 7402.5 |
| JMJD6 | 4660.0 | 7122.0 |
| KDM1A | -6245.0 | -6064.0 |
| KDM1B | 6297.0 | 4922.0 |
| KDM2A | -2499.0 | 5906.0 |
| KDM2B | -10632.0 | -8855.0 |
| KDM3A | -9927.0 | -11194.0 |
| KDM3B | 6054.0 | 9282.0 |
| KDM4A | -5855.0 | 4280.0 |
| KDM4B | 6479.0 | 8890.0 |
| KDM4C | -9638.0 | -6288.0 |
| KDM5A | -6036.0 | 1492.0 |
| KDM5B | -1367.0 | 7624.0 |
| KDM5C | -4837.0 | 6795.0 |
| KDM5D | -3677.0 | -114.0 |
| KDM6A | -3419.0 | 5092.0 |
| KDM6B | 9279.0 | 8987.0 |
| KDM7A | 8052.0 | 6799.0 |
| PHF2 | 2150.0 | 7499.0 |
| PHF8 | -6137.0 | 4275.0 |
| UTY | -1906.0 | -493.0 |
SUMOylation of immune response proteins
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00714 |
| p.adjustMANOVA | 0.0194 |
| s.dist | 0.522 |
| s.low.CRP | 0.139 |
| s.high.CRP | 0.503 |
| p.low.CRP | 0.425 |
| p.high.CRP | 0.00388 |
| Gene | low CRP | high CRP |
|---|---|---|
| SUMO1 | 7968 | 6798 |
| SUMO3 | 6805 | 7483 |
| NFKBIA | 6855 | 7374 |
| TOPORS | 4682 | 2877 |
| IKBKE | 387 | 6793 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| IKBKE | 387 | 6793 |
| IKBKG | -3058 | 7903 |
| NFKB2 | 3069 | -1167 |
| NFKBIA | 6855 | 7374 |
| PIAS3 | -3766 | 1150 |
| PIAS4 | -1432 | 8309 |
| RELA | -7305 | 2739 |
| SUMO1 | 7968 | 6798 |
| SUMO3 | 6805 | 7483 |
| TOPORS | 4682 | 2877 |
| UBE2I | -4201 | 2754 |
Abortive elongation of HIV-1 transcript in the absence of Tat
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 0.00222 |
| p.adjustMANOVA | 0.0071 |
| s.dist | 0.284 |
| s.low.CRP | -0.0883 |
| s.high.CRP | 0.27 |
| p.low.CRP | 0.464 |
| p.high.CRP | 0.0248 |
| Gene | low CRP | high CRP |
|---|---|---|
| CTDP1 | -5483 | 8151 |
| NELFB | -8446 | 5056 |
| POLR2G | -5778 | 6576 |
| NELFE | -4877 | 6342 |
| POLR2A | -8726 | 2901 |
| GTF2F1 | -3109 | 7342 |
| SUPT4H1 | -3945 | 5159 |
| POLR2F | -2307 | 6746 |
| POLR2C | -2183 | 3527 |
| POLR2I | -2123 | 2695 |
| POLR2B | -1034 | 188 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CTDP1 | -5483 | 8151 |
| GTF2F1 | -3109 | 7342 |
| GTF2F2 | 4728 | 6017 |
| NCBP1 | 1766 | -6055 |
| NCBP2 | 3719 | -10143 |
| NELFA | -2921 | -970 |
| NELFB | -8446 | 5056 |
| NELFCD | -3646 | -4090 |
| NELFE | -4877 | 6342 |
| POLR2A | -8726 | 2901 |
| POLR2B | -1034 | 188 |
| POLR2C | -2183 | 3527 |
| POLR2D | 3401 | -4083 |
| POLR2E | 6766 | 8343 |
| POLR2F | -2307 | 6746 |
| POLR2G | -5778 | 6576 |
| POLR2H | 653 | -2264 |
| POLR2I | -2123 | 2695 |
| POLR2J | 4448 | 7822 |
| POLR2K | 1881 | -1885 |
| POLR2L | 126 | 7246 |
| SUPT4H1 | -3945 | 5159 |
| SUPT5H | -7894 | -1035 |
Retrograde neurotrophin signalling
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000584 |
| p.adjustMANOVA | 0.00231 |
| s.dist | 0.682 |
| s.low.CRP | 0.269 |
| s.high.CRP | 0.626 |
| p.low.CRP | 0.106 |
| p.high.CRP | 0.000173 |
| Gene | low CRP | high CRP |
|---|---|---|
| CLTC | 9376 | 9720 |
| CLTA | 8416 | 8998 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| DNM3 | 7927 | 7198 |
| AP2A2 | 3196 | 9217 |
| DNM1 | 6883 | 3239 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -3194 | 9104 |
| AP2A2 | 3196 | 9217 |
| AP2B1 | -9145 | 2444 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| CLTA | 8416 | 8998 |
| CLTC | 9376 | 9720 |
| DNAL4 | -697 | 5475 |
| DNM1 | 6883 | 3239 |
| DNM2 | -6816 | 8202 |
| DNM3 | 7927 | 7198 |
| NTRK1 | -3499 | -8157 |
FCERI mediated Ca+2 mobilization
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 2.55e-10 |
| p.adjustMANOVA | 5.18e-09 |
| s.dist | 0.26 |
| s.low.CRP | 0.136 |
| s.high.CRP | -0.221 |
| p.low.CRP | 0.0278 |
| p.high.CRP | 0.000334 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| SOS1 | 3534 | -7412 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AHCYL1 | 6114 | 7566 |
| BTK | 7623 | 7870 |
| CALM1 | -6645 | 1321 |
| GRAP2 | 5425 | 4991 |
| GRB2 | 9631 | 9985 |
| IGHE | -498 | -5753 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| ITK | -7038 | -10924 |
| ITPR1 | -5546 | -5368 |
| ITPR2 | 6833 | 6418 |
| ITPR3 | -8438 | -9066 |
| LAT | -9843 | -10628 |
| LCP2 | -2426 | 872 |
| LYN | 7575 | 8379 |
| NFATC1 | -9648 | -4795 |
| NFATC2 | -11185 | -10445 |
| NFATC3 | -10822 | -10053 |
| PLCG1 | -6360 | -11043 |
| PLCG2 | -4618 | 6826 |
| PPP3CA | 6208 | 7300 |
| PPP3CB | 8057 | 6833 |
| PPP3R1 | 8998 | 8570 |
| SHC1 | -3416 | 5815 |
| SOS1 | 3534 | -7412 |
| SYK | 9464 | 9848 |
| TEC | 8165 | 7953 |
| TXK | -9905 | -10778 |
| VAV1 | 5553 | 8731 |
| VAV2 | -5033 | -1339 |
| VAV3 | -6160 | 7203 |
FCERI mediated MAPK activation
| metric | value |
|---|---|
| setSize | 89 |
| pMANOVA | 2.7e-10 |
| p.adjustMANOVA | 5.39e-09 |
| s.dist | 0.258 |
| s.low.CRP | 0.221 |
| s.high.CRP | -0.133 |
| p.low.CRP | 0.000306 |
| p.high.CRP | 0.0302 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGLV5-45 | 4194 | -7364 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| SOS1 | 3534 | -7412 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGLV1-36 | 3522 | -5030 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| FOS | 6663 | 6569 |
| GRAP2 | 5425 | 4991 |
| GRB2 | 9631 | 9985 |
| HRAS | -2248 | -1932 |
| IGHE | -498 | -5753 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-36 | 3522 | -5030 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV10-54 | -5422 | 316 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-18 | 2015 | -2963 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-12 | -7299 | -6816 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV4-69 | 1344 | -2261 |
| IGLV5-45 | 4194 | -7364 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| IGLV7-46 | 2445 | -3619 |
| IGLV8-61 | -3989 | -5208 |
| JUN | 2838 | 4810 |
| KRAS | 3789 | 4070 |
| LAT | -9843 | -10628 |
| LCP2 | -2426 | 872 |
| LYN | 7575 | 8379 |
| MAP2K4 | 6895 | 7431 |
| MAP2K7 | -2754 | 4813 |
| MAP3K1 | 5466 | 5938 |
| MAPK1 | 1052 | 9260 |
| MAPK10 | 6734 | 3872 |
| MAPK3 | 8931 | 9626 |
| MAPK8 | -1061 | -9914 |
| MAPK9 | -6530 | -1870 |
| NRAS | 7321 | 4878 |
| PAK1 | 9711 | 7682 |
| PAK2 | 9019 | 8433 |
| PLCG1 | -6360 | -11043 |
| PLCG2 | -4618 | 6826 |
| RAC1 | 9052 | 9614 |
| SHC1 | -3416 | 5815 |
| SOS1 | 3534 | -7412 |
| SYK | 9464 | 9848 |
| VAV1 | 5553 | 8731 |
| VAV2 | -5033 | -1339 |
| VAV3 | -6160 | 7203 |
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000102 |
| p.adjustMANOVA | 0.000496 |
| s.dist | 0.841 |
| s.low.CRP | 0.395 |
| s.high.CRP | 0.742 |
| p.low.CRP | 0.0232 |
| p.high.CRP | 2.01e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| FZD5 | 10104 | 10128 |
| CLTC | 9376 | 9720 |
| CLTA | 8416 | 8998 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| FZD2 | 6675 | 7410 |
| AP2A2 | 3196 | 9217 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -3194 | 9104 |
| AP2A2 | 3196 | 9217 |
| AP2B1 | -9145 | 2444 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| CLTA | 8416 | 8998 |
| CLTB | -2857 | 8274 |
| CLTC | 9376 | 9720 |
| FZD2 | 6675 | 7410 |
| FZD5 | 10104 | 10128 |
| ROR1 | 2411 | -2323 |
GPVI-mediated activation cascade
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 3.29e-05 |
| p.adjustMANOVA | 0.000179 |
| s.dist | 0.412 |
| s.low.CRP | 0.0632 |
| s.high.CRP | 0.407 |
| p.low.CRP | 0.542 |
| p.high.CRP | 8.7e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| SYK | 9464 | 9848 |
| PIK3CB | 9838 | 9248 |
| RAC1 | 9052 | 9614 |
| CLEC1B | 9832 | 8778 |
| RHOA | 8351 | 8888 |
| RHOG | 7549 | 9255 |
| CDC42 | 8498 | 7640 |
| LYN | 7575 | 8379 |
| FCER1G | 6595 | 9147 |
| PIK3R6 | 8267 | 7206 |
| GP6 | 7137 | 7699 |
| VAV1 | 5553 | 8731 |
| PTPN11 | 4691 | 6614 |
| PIK3CA | 6889 | 4182 |
| PDPK1 | 2392 | 7816 |
| PIK3R2 | 2459 | 5820 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CDC42 | 8498 | 7640 |
| CLEC1B | 9832 | 8778 |
| FCER1G | 6595 | 9147 |
| FYN | -10878 | -6729 |
| GP6 | 7137 | 7699 |
| LAT | -9843 | -10628 |
| LCK | -10358 | -10719 |
| LCP2 | -2426 | 872 |
| LYN | 7575 | 8379 |
| PDPK1 | 2392 | 7816 |
| PIK3CA | 6889 | 4182 |
| PIK3CB | 9838 | 9248 |
| PIK3CG | -9742 | 5545 |
| PIK3R1 | -7197 | -8942 |
| PIK3R2 | 2459 | 5820 |
| PIK3R3 | -11107 | -8159 |
| PIK3R5 | -9700 | 3911 |
| PIK3R6 | 8267 | 7206 |
| PLCG2 | -4618 | 6826 |
| PRKCZ | -10855 | -7708 |
| PTPN11 | 4691 | 6614 |
| PTPN6 | -691 | 7862 |
| RAC1 | 9052 | 9614 |
| RAC2 | -7677 | 6828 |
| RHOA | 8351 | 8888 |
| RHOB | -4807 | 3859 |
| RHOG | 7549 | 9255 |
| SYK | 9464 | 9848 |
| VAV1 | 5553 | 8731 |
| VAV2 | -5033 | -1339 |
| VAV3 | -6160 | 7203 |
Synthesis of Leukotrienes (LT) and Eoxins (EX)
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.0158 |
| p.adjustMANOVA | 0.0365 |
| s.dist | 0.338 |
| s.low.CRP | -0.000913 |
| s.high.CRP | 0.338 |
| p.low.CRP | 0.995 |
| p.high.CRP | 0.0234 |
| Gene | low CRP | high CRP |
|---|---|---|
| MAPKAPK2 | -10572 | 6892 |
| LTC4S | -7039 | 2930 |
| GGT5 | -6888 | 1713 |
| CYP4F8 | -3981 | 186 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ABCC1 | 686 | 2817 |
| ALOX15 | -6345 | -9981 |
| ALOX5 | 9516 | 9496 |
| ALOX5AP | 4064 | 8312 |
| CYP4F22 | -11214 | -10272 |
| CYP4F3 | 5306 | 6371 |
| CYP4F8 | -3981 | 186 |
| DPEP2 | -4986 | -926 |
| DPEP3 | -4594 | -1297 |
| GGT1 | 8068 | 10073 |
| GGT5 | -6888 | 1713 |
| LTA4H | 9933 | 9541 |
| LTC4S | -7039 | 2930 |
| MAPKAPK2 | -10572 | 6892 |
| PTGR1 | 9237 | 9969 |
AKT phosphorylates targets in the cytosol
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00216 |
| p.adjustMANOVA | 0.00702 |
| s.dist | 0.541 |
| s.low.CRP | 0.176 |
| s.high.CRP | 0.511 |
| p.low.CRP | 0.254 |
| p.high.CRP | 0.000921 |
| Gene | low CRP | high CRP |
|---|---|---|
| MKRN1 | 9789 | 8565 |
| CHUK | 9198 | 7663 |
| AKT1S1 | 8045 | 8241 |
| CASP9 | 5303 | 9133 |
| GSK3B | 6119 | 7526 |
| GSK3A | 5279 | 8683 |
| MDM2 | 7204 | 3892 |
| CDKN1A | 3621 | 5190 |
| BAD | 1009 | 8765 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AKT1 | -4794 | 6231 |
| AKT1S1 | 8045 | 8241 |
| AKT2 | -8391 | 5504 |
| AKT3 | -9616 | -10833 |
| BAD | 1009 | 8765 |
| CASP9 | 5303 | 9133 |
| CDKN1A | 3621 | 5190 |
| CDKN1B | -9926 | -2672 |
| CHUK | 9198 | 7663 |
| GSK3A | 5279 | 8683 |
| GSK3B | 6119 | 7526 |
| MDM2 | 7204 | 3892 |
| MKRN1 | 9789 | 8565 |
| TSC2 | -4535 | 2859 |
RHO GTPases activate CIT
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.00161 |
| p.adjustMANOVA | 0.00548 |
| s.dist | 0.455 |
| s.low.CRP | 0.109 |
| s.high.CRP | 0.442 |
| p.low.CRP | 0.424 |
| p.high.CRP | 0.00116 |
| Gene | low CRP | high CRP |
|---|---|---|
| DLG4 | 9905 | 8876 |
| RAC1 | 9052 | 9614 |
| MYL9 | 9640 | 7741 |
| RHOA | 8351 | 8888 |
| MYL6 | 6786 | 9643 |
| PPP1CB | 8657 | 6666 |
| PPP1R12A | 5601 | 6368 |
| MYH9 | 1879 | 8348 |
| KIF14 | 1714 | 3512 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CDKN1B | -9926 | -2672 |
| CIT | -7580 | -2898 |
| DLG4 | 9905 | 8876 |
| KIF14 | 1714 | 3512 |
| MYH10 | -7101 | 3044 |
| MYH11 | 1903 | -4778 |
| MYH9 | 1879 | 8348 |
| MYL12B | -2612 | 6816 |
| MYL6 | 6786 | 9643 |
| MYL9 | 9640 | 7741 |
| PPP1CB | 8657 | 6666 |
| PPP1R12A | 5601 | 6368 |
| PPP1R12B | -4326 | 4036 |
| PRC1 | -5431 | 2601 |
| RAC1 | 9052 | 9614 |
| RHOA | 8351 | 8888 |
| RHOB | -4807 | 3859 |
| RHOC | -11158 | -4627 |
Suppression of phagosomal maturation
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00724 |
| p.adjustMANOVA | 0.0195 |
| s.dist | 0.517 |
| s.low.CRP | 0.161 |
| s.high.CRP | 0.492 |
| p.low.CRP | 0.335 |
| p.high.CRP | 0.00319 |
| Gene | low CRP | high CRP |
|---|---|---|
| RAB7A | 8897 | 9367 |
| ATP6V1H | 7942 | 8571 |
| RAB5A | 8478 | 6815 |
| UBB | 8251 | 6157 |
| KPNA1 | 4214 | 1618 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ATP6V1H | 7942 | 8571 |
| CORO1A | -5520 | 7058 |
| HGS | -381 | 6840 |
| KPNA1 | 4214 | 1618 |
| KPNB1 | -1223 | 3575 |
| RAB5A | 8478 | 6815 |
| RAB7A | 8897 | 9367 |
| RPS27A | -3555 | -7070 |
| UBA52 | -1875 | 3023 |
| UBB | 8251 | 6157 |
| UBC | -1915 | 5825 |
| VPS33B | -9608 | 4599 |
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
| metric | value |
|---|---|
| setSize | 83 |
| pMANOVA | 2.23e-08 |
| p.adjustMANOVA | 3.13e-07 |
| s.dist | 0.237 |
| s.low.CRP | 0.134 |
| s.high.CRP | -0.196 |
| p.low.CRP | 0.0354 |
| p.high.CRP | 0.00207 |
| Gene | low CRP | high CRP |
|---|---|---|
| IGKV3-11 | 5548 | -7167 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-5 | 6127 | -5162 |
| IGHV3-23 | 6032 | -5092 |
| IGKV2-30 | 5205 | -5349 |
| IGLV1-44 | 4742 | -5791 |
| IGHV4-59 | 4532 | -5870 |
| SOS1 | 3534 | -7412 |
| IGLV2-8 | 4818 | -5256 |
| IGHV4-39 | 3786 | -6542 |
| IGLV3-19 | 4006 | -5611 |
| IGHV1-2 | 5956 | -3146 |
| IGKV3-20 | 3704 | -5021 |
| IGKC | 2773 | -6437 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-7 | 4185 | -3630 |
| IGKV3-15 | 3174 | -4687 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AHCYL1 | 6114 | 7566 |
| BLK | -5294 | -3774 |
| BLNK | -5690 | -5869 |
| BTK | 7623 | 7870 |
| CALM1 | -6645 | 1321 |
| CD19 | -2992 | -2929 |
| CD22 | -3032 | -4243 |
| CD79A | -3264 | -4267 |
| CD79B | -6240 | -6157 |
| DAPP1 | 9222 | 3322 |
| FYN | -10878 | -6729 |
| GRB2 | 9631 | 9985 |
| IGHD | -2028 | -4193 |
| IGHM | 1890 | -2470 |
| IGHV1-2 | 5956 | -3146 |
| IGHV1-46 | 3766 | -2976 |
| IGHV1-69 | 2354 | -2328 |
| IGHV2-5 | 4451 | -1972 |
| IGHV2-70 | -3315 | -2159 |
| IGHV3-11 | 3518 | -4591 |
| IGHV3-13 | 799 | -2451 |
| IGHV3-23 | 6032 | -5092 |
| IGHV3-30 | 2500 | -5193 |
| IGHV3-33 | 98 | -4138 |
| IGHV3-48 | 3183 | -4340 |
| IGHV3-53 | 3131 | -1786 |
| IGHV3-7 | 4185 | -3630 |
| IGHV4-34 | 1144 | -4007 |
| IGHV4-39 | 3786 | -6542 |
| IGHV4-59 | 4532 | -5870 |
| IGKC | 2773 | -6437 |
| IGKV1-12 | 725 | -6674 |
| IGKV1-16 | 6217 | -5451 |
| IGKV1-17 | -241 | -2794 |
| IGKV1-33 | 5955 | -6384 |
| IGKV1-5 | 6127 | -5162 |
| IGKV1D-39 | 5018 | -2677 |
| IGKV2-28 | 1440 | -6662 |
| IGKV2-30 | 5205 | -5349 |
| IGKV2D-28 | -7224 | -2947 |
| IGKV3-11 | 5548 | -7167 |
| IGKV3-15 | 3174 | -4687 |
| IGKV3-20 | 3704 | -5021 |
| IGKV3D-20 | -1830 | -4618 |
| IGKV4-1 | 2812 | -4988 |
| IGKV5-2 | 5226 | -2682 |
| IGLC1 | -2813 | -6176 |
| IGLC2 | -258 | -6539 |
| IGLC3 | -2958 | -4378 |
| IGLC7 | -3403 | -4490 |
| IGLV1-40 | 163 | -5497 |
| IGLV1-44 | 4742 | -5791 |
| IGLV1-47 | 231 | -6633 |
| IGLV1-51 | 1708 | -6601 |
| IGLV2-11 | 870 | -3205 |
| IGLV2-14 | -5127 | -8197 |
| IGLV2-23 | 2029 | -4201 |
| IGLV2-8 | 4818 | -5256 |
| IGLV3-1 | -96 | -5140 |
| IGLV3-19 | 4006 | -5611 |
| IGLV3-21 | -975 | -6062 |
| IGLV3-25 | -942 | -5485 |
| IGLV3-27 | -5365 | -4834 |
| IGLV6-57 | 1834 | -5837 |
| IGLV7-43 | 4854 | -2823 |
| ITPR1 | -5546 | -5368 |
| ITPR2 | 6833 | 6418 |
| ITPR3 | -8438 | -9066 |
| LYN | 7575 | 8379 |
| NCK1 | -9250 | -9113 |
| ORAI1 | -9219 | -1368 |
| ORAI2 | 775 | 6855 |
| PIK3AP1 | 6149 | 8581 |
| PIK3CD | 82 | 7288 |
| PIK3R1 | -7197 | -8942 |
| PLCG2 | -4618 | 6826 |
| PTPN6 | -691 | 7862 |
| SH3KBP1 | 4345 | 7311 |
| SOS1 | 3534 | -7412 |
| STIM1 | -9148 | 7796 |
| SYK | 9464 | 9848 |
| TRPC1 | -2448 | -10832 |
| VAV1 | 5553 | 8731 |
Trafficking of GluR2-containing AMPA receptors
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00483 |
| p.adjustMANOVA | 0.0139 |
| s.dist | 0.554 |
| s.low.CRP | 0.191 |
| s.high.CRP | 0.519 |
| p.low.CRP | 0.252 |
| p.high.CRP | 0.00183 |
| Gene | low CRP | high CRP |
|---|---|---|
| NSF | 8895 | 9680 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| TSPAN7 | 7804 | 6540 |
| PRKCB | 5395 | 8378 |
| AP2A2 | 3196 | 9217 |
| PRKCA | 2473 | 1229 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AP2A1 | -3194 | 9104 |
| AP2A2 | 3196 | 9217 |
| AP2B1 | -9145 | 2444 |
| AP2M1 | 7742 | 9334 |
| AP2S1 | 7422 | 8877 |
| GRIA4 | -998 | 602 |
| GRIP1 | -4378 | -11086 |
| NSF | 8895 | 9680 |
| PICK1 | -7615 | 5643 |
| PRKCA | 2473 | 1229 |
| PRKCB | 5395 | 8378 |
| TSPAN7 | 7804 | 6540 |
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.0106 |
| p.adjustMANOVA | 0.0269 |
| s.dist | 0.367 |
| s.low.CRP | 0.038 |
| s.high.CRP | 0.365 |
| p.low.CRP | 0.793 |
| p.high.CRP | 0.0114 |
| Gene | low CRP | high CRP |
|---|---|---|
| FKBP1A | 9920 | 8990 |
| F11R | 8751 | 8489 |
| RHOA | 8351 | 8888 |
| PARD3 | 7352 | 7983 |
| UBB | 8251 | 6157 |
| CGN | 7428 | 1125 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARHGEF18 | -8526 | -2076 |
| CGN | 7428 | 1125 |
| F11R | 8751 | 8489 |
| FKBP1A | 9920 | 8990 |
| PARD3 | 7352 | 7983 |
| PARD6A | -1188 | 1317 |
| PRKCZ | -10855 | -7708 |
| RHOA | 8351 | 8888 |
| RPS27A | -3555 | -7070 |
| SMURF1 | -9318 | 2452 |
| TGFB1 | -2566 | 6745 |
| TGFBR1 | -7960 | 3224 |
| TGFBR2 | -5037 | 6173 |
| UBA52 | -1875 | 3023 |
| UBB | 8251 | 6157 |
| UBC | -1915 | 5825 |
rRNA processing in the mitochondrion
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 0.000507 |
| p.adjustMANOVA | 0.00203 |
| s.dist | 0.336 |
| s.low.CRP | -0.336 |
| s.high.CRP | -0.0104 |
| p.low.CRP | 0.00175 |
| p.high.CRP | 0.922 |
| Gene | low CRP | high CRP |
|---|---|---|
| TFB1M | -8567 | -10206 |
| MTERF4 | -7847 | -10347 |
| MRM1 | -7443 | -9320 |
| ELAC2 | -10756 | -5453 |
| MT-TL2 | -9294 | -2861 |
| MRM3 | -6571 | -3775 |
| MT-ND2 | -6369 | -3767 |
| NSUN4 | -3781 | -2571 |
| MT-ND1 | -3881 | -1394 |
| MT-ND3 | -4723 | -1060 |
| MT-CYB | -2748 | -78 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ELAC2 | -10756 | -5453 |
| HSD17B10 | -1197 | 6037 |
| MRM1 | -7443 | -9320 |
| MRM2 | 5250 | 1415 |
| MRM3 | -6571 | -3775 |
| MT-ATP6 | -6161 | 1833 |
| MT-ATP8 | -8699 | 3719 |
| MT-CO1 | 575 | 1906 |
| MT-CO2 | -1994 | 1965 |
| MT-CO3 | -1724 | 2140 |
| MT-CYB | -2748 | -78 |
| MT-ND1 | -3881 | -1394 |
| MT-ND2 | -6369 | -3767 |
| MT-ND3 | -4723 | -1060 |
| MT-ND4 | 1457 | 1379 |
| MT-ND4L | -6001 | 1900 |
| MT-ND5 | -3288 | 283 |
| MT-RNR1 | -1023 | 1206 |
| MT-RNR2 | -373 | 3642 |
| MT-TF | -8605 | 1267 |
| MT-TL1 | -8729 | 1284 |
| MT-TL2 | -9294 | -2861 |
| MT-TM | -9490 | 3091 |
| MT-TV | -9270 | 940 |
| MTERF4 | -7847 | -10347 |
| NSUN4 | -3781 | -2571 |
| PRORP | 5623 | 3349 |
| TFB1M | -8567 | -10206 |
| TRMT10C | 4825 | -5987 |
Sealing of the nuclear envelope (NE) by ESCRT-III
| metric | value |
|---|---|
| setSize | 25 |
| pMANOVA | 3.17e-05 |
| p.adjustMANOVA | 0.000176 |
| s.dist | 0.528 |
| s.low.CRP | 0.175 |
| s.high.CRP | 0.498 |
| p.low.CRP | 0.131 |
| p.high.CRP | 1.6e-05 |
| Gene | low CRP | high CRP |
|---|---|---|
| CHMP4B | 8338 | 9679 |
| CHMP2A | 8348 | 9510 |
| CHMP3 | 8980 | 8782 |
| TUBB2A | 8108 | 9349 |
| TUBA8 | 8044 | 7112 |
| SPAST | 8135 | 6987 |
| TUBA1C | 7082 | 7744 |
| TUBB4B | 6246 | 7789 |
| TUBA1A | 6178 | 7845 |
| CHMP2B | 7436 | 5296 |
| TUBB1 | 6239 | 6225 |
| TUBB6 | 1680 | 7491 |
| TUBA1B | 1572 | 6394 |
| TUBA4A | 652 | 7677 |
| IST1 | 260 | 7296 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| CC2D1B | -10559 | -1584 |
| CHMP2A | 8348 | 9510 |
| CHMP2B | 7436 | 5296 |
| CHMP3 | 8980 | 8782 |
| CHMP4A | -1130 | 4862 |
| CHMP4B | 8338 | 9679 |
| CHMP6 | -6653 | 8292 |
| CHMP7 | -4593 | -8038 |
| IST1 | 260 | 7296 |
| LEMD2 | -9649 | 6162 |
| SPAST | 8135 | 6987 |
| TUBA1A | 6178 | 7845 |
| TUBA1B | 1572 | 6394 |
| TUBA1C | 7082 | 7744 |
| TUBA3D | -4511 | -9736 |
| TUBA4A | 652 | 7677 |
| TUBA4B | -4789 | 3660 |
| TUBA8 | 8044 | 7112 |
| TUBB1 | 6239 | 6225 |
| TUBB2A | 8108 | 9349 |
| TUBB3 | -1306 | 3835 |
| TUBB4A | -6145 | -8199 |
| TUBB4B | 6246 | 7789 |
| TUBB6 | 1680 | 7491 |
| VPS4A | -5744 | 4778 |
BBSome-mediated cargo-targeting to cilium
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 0.00802 |
| p.adjustMANOVA | 0.0212 |
| s.dist | 0.272 |
| s.low.CRP | 0.0508 |
| s.high.CRP | -0.268 |
| p.low.CRP | 0.68 |
| p.high.CRP | 0.0298 |
| Gene | low CRP | high CRP |
|---|---|---|
| BBIP1 | 6199 | -8379 |
| CCT2 | 1978 | -8922 |
| LZTFL1 | 1730 | -7901 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARL6 | -6388 | -9392 |
| BBIP1 | 6199 | -8379 |
| BBS1 | -4722 | -8914 |
| BBS10 | -5216 | -6916 |
| BBS12 | -3237 | -3751 |
| BBS2 | -6226 | -8744 |
| BBS4 | -9893 | -8667 |
| BBS5 | -2607 | -7149 |
| BBS7 | 7837 | 708 |
| BBS9 | -7889 | -7637 |
| CCT2 | 1978 | -8922 |
| CCT3 | -1967 | 394 |
| CCT4 | 5187 | 393 |
| CCT5 | 8265 | 6849 |
| CCT8 | 8723 | 5878 |
| LZTFL1 | 1730 | -7901 |
| MCHR1 | -3531 | -4084 |
| MKKS | 7131 | 2033 |
| RAB3IP | 6917 | 2082 |
| SSTR3 | -7134 | -9333 |
| TCP1 | 7677 | 2853 |
| TTC8 | -3586 | 3343 |
Regulated proteolysis of p75NTR
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00894 |
| p.adjustMANOVA | 0.0231 |
| s.dist | 0.547 |
| s.low.CRP | 0.194 |
| s.high.CRP | 0.512 |
| p.low.CRP | 0.266 |
| p.high.CRP | 0.00327 |
| Gene | low CRP | high CRP |
|---|---|---|
| NCSTN | 9503 | 9869 |
| ADAM17 | 8058 | 9718 |
| PSEN1 | 7889 | 8878 |
| NFKB1 | 7857 | 6377 |
| APH1B | 6306 | 6678 |
| PSENEN | 2692 | 7551 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ADAM17 | 8058 | 9718 |
| APH1A | -3379 | 6321 |
| APH1B | 6306 | 6678 |
| NCSTN | 9503 | 9869 |
| NFKB1 | 7857 | 6377 |
| NGFR | -8252 | -253 |
| PSEN1 | 7889 | 8878 |
| PSEN2 | -5169 | -5867 |
| PSENEN | 2692 | 7551 |
| RELA | -7305 | 2739 |
| TRAF6 | -1767 | 2089 |
Sema4D in semaphorin signaling
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 0.000376 |
| p.adjustMANOVA | 0.00156 |
| s.dist | 0.475 |
| s.low.CRP | 0.138 |
| s.high.CRP | 0.455 |
| p.low.CRP | 0.264 |
| p.high.CRP | 0.000223 |
| Gene | low CRP | high CRP |
|---|---|---|
| ARHGEF11 | 9867 | 9882 |
| RAC1 | 9052 | 9614 |
| MYL9 | 9640 | 7741 |
| RHOA | 8351 | 8888 |
| LIMK2 | 8349 | 8299 |
| ROCK1 | 8315 | 7930 |
| MYL6 | 6786 | 9643 |
| ROCK2 | 7628 | 6719 |
| PLXNB1 | 4183 | 6269 |
| MYH9 | 1879 | 8348 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARHGAP35 | -6993 | 1378 |
| ARHGEF11 | 9867 | 9882 |
| ARHGEF12 | -213 | 4295 |
| ERBB2 | -11251 | -9287 |
| LIMK1 | -2747 | 6617 |
| LIMK2 | 8349 | 8299 |
| MYH10 | -7101 | 3044 |
| MYH11 | 1903 | -4778 |
| MYH9 | 1879 | 8348 |
| MYL12B | -2612 | 6816 |
| MYL6 | 6786 | 9643 |
| MYL9 | 9640 | 7741 |
| PLXNB1 | 4183 | 6269 |
| RAC1 | 9052 | 9614 |
| RHOA | 8351 | 8888 |
| RHOB | -4807 | 3859 |
| RHOC | -11158 | -4627 |
| RND1 | -1747 | -757 |
| ROCK1 | 8315 | 7930 |
| ROCK2 | 7628 | 6719 |
| RRAS | -5315 | 5342 |
| SEMA4D | -2346 | -627 |
Post-chaperonin tubulin folding pathway
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 0.00549 |
| p.adjustMANOVA | 0.0155 |
| s.dist | 0.367 |
| s.low.CRP | 0.0476 |
| s.high.CRP | 0.364 |
| p.low.CRP | 0.719 |
| p.high.CRP | 0.00599 |
| Gene | low CRP | high CRP |
|---|---|---|
| TUBB2A | 8108 | 9349 |
| TUBA8 | 8044 | 7112 |
| TUBA1C | 7082 | 7744 |
| TUBB4B | 6246 | 7789 |
| TUBA1A | 6178 | 7845 |
| TUBB1 | 6239 | 6225 |
| TBCA | 5661 | 5870 |
| TUBB6 | 1680 | 7491 |
| TUBA1B | 1572 | 6394 |
| TUBA4A | 652 | 7677 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| ARL2 | -5078 | 2617 |
| TBCA | 5661 | 5870 |
| TBCB | -7971 | 6771 |
| TBCC | -10293 | -4108 |
| TBCD | -9289 | -5231 |
| TBCE | -3383 | 256 |
| TUBA1A | 6178 | 7845 |
| TUBA1B | 1572 | 6394 |
| TUBA1C | 7082 | 7744 |
| TUBA3D | -4511 | -9736 |
| TUBA4A | 652 | 7677 |
| TUBA4B | -4789 | 3660 |
| TUBA8 | 8044 | 7112 |
| TUBB1 | 6239 | 6225 |
| TUBB2A | 8108 | 9349 |
| TUBB3 | -1306 | 3835 |
| TUBB4A | -6145 | -8199 |
| TUBB4B | 6246 | 7789 |
| TUBB6 | 1680 | 7491 |
Constitutive Signaling by AKT1 E17K in Cancer
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 0.00424 |
| p.adjustMANOVA | 0.0125 |
| s.dist | 0.265 |
| s.low.CRP | -0.0539 |
| s.high.CRP | 0.259 |
| p.low.CRP | 0.634 |
| p.high.CRP | 0.0223 |
| Gene | low CRP | high CRP |
|---|---|---|
| AKT2 | -8391 | 5504 |
| AKT1 | -4794 | 6231 |
| RPS6KB2 | -4855 | 4416 |
| TSC2 | -4535 | 2859 |
| MLST8 | -3991 | 2978 |
| FOXO4 | -615 | 8296 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| AKT1 | -4794 | 6231 |
| AKT1S1 | 8045 | 8241 |
| AKT2 | -8391 | 5504 |
| AKT3 | -9616 | -10833 |
| BAD | 1009 | 8765 |
| CASP9 | 5303 | 9133 |
| CDKN1A | 3621 | 5190 |
| CDKN1B | -9926 | -2672 |
| CHUK | 9198 | 7663 |
| CREB1 | 4878 | -3476 |
| FOXO1 | -4402 | -9319 |
| FOXO3 | 8202 | 9854 |
| FOXO4 | -615 | 8296 |
| FOXO6 | -9309 | -1189 |
| GSK3A | 5279 | 8683 |
| GSK3B | 6119 | 7526 |
| MAPKAP1 | 2536 | 5925 |
| MDM2 | 7204 | 3892 |
| MLST8 | -3991 | 2978 |
| MTOR | -10419 | -3248 |
| NR4A1 | -7773 | -6467 |
| PDPK1 | 2392 | 7816 |
| PRR5 | -11173 | -8620 |
| RICTOR | -3978 | -9726 |
| RPS6KB2 | -4855 | 4416 |
| TSC2 | -4535 | 2859 |
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0186 |
| p.adjustMANOVA | 0.0411 |
| s.dist | 0.485 |
| s.low.CRP | 0.149 |
| s.high.CRP | 0.461 |
| p.low.CRP | 0.392 |
| p.high.CRP | 0.0081 |
| Gene | low CRP | high CRP |
|---|---|---|
| PRKACA | 9885 | 10068 |
| PFKFB4 | 9668 | 9897 |
| PPP2CA | 8810 | 8328 |
| PFKFB3 | 7624 | 9236 |
| PPP2CB | 8482 | 7631 |
| PPP2R1B | 2503 | 437 |
Click HERE to show all gene set members
| low CRP | high CRP | |
|---|---|---|
| PFKFB1 | -7223 | -6744 |
| PFKFB2 | -9116 | 8194 |
| PFKFB3 | 7624 | 9236 |
| PFKFB4 | 9668 | 9897 |
| PPP2CA | 8810 | 8328 |
| PPP2CB | 8482 | 7631 |
| PPP2R1A | -3087 | 6994 |
| PPP2R1B | 2503 | 437 |
| PPP2R5D | -6508 | 4985 |
| PRKACA | 9885 | 10068 |
| PRKACB | -9852 | -10936 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.3 (2020-10-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0
## [3] beeswarm_0.2.3 gtools_3.8.2
## [5] echarts4r_0.3.3 eulerr_6.1.0
## [7] mitch_1.2.2 MASS_7.3-53
## [9] fgsea_1.16.0 gplots_3.1.0
## [11] DESeq2_1.30.0 SummarizedExperiment_1.20.0
## [13] Biobase_2.50.0 MatrixGenerics_1.2.0
## [15] matrixStats_0.57.0 GenomicRanges_1.42.0
## [17] GenomeInfoDb_1.26.0 IRanges_2.24.0
## [19] S4Vectors_0.28.0 BiocGenerics_0.36.0
## [21] reshape2_1.4.4 forcats_0.5.0
## [23] stringr_1.4.0 dplyr_1.0.2
## [25] purrr_0.3.4 readr_1.4.0
## [27] tidyr_1.1.2 tibble_3.0.4
## [29] ggplot2_3.3.2 tidyverse_1.3.0
##
## loaded via a namespace (and not attached):
## [1] colorspace_2.0-0 ellipsis_0.3.1 rprojroot_1.3-2
## [4] XVector_0.30.0 fs_1.5.0 rstudioapi_0.12
## [7] farver_2.0.3 bit64_4.0.5 AnnotationDbi_1.52.0
## [10] fansi_0.4.1 lubridate_1.7.9 xml2_1.3.2
## [13] splines_4.0.3 geneplotter_1.68.0 knitr_1.30
## [16] polyclip_1.10-0 jsonlite_1.7.1 broom_0.7.2
## [19] annotate_1.68.0 dbplyr_2.0.0 shiny_1.5.0
## [22] compiler_4.0.3 httr_1.4.2 backports_1.2.0
## [25] assertthat_0.2.1 Matrix_1.2-18 fastmap_1.0.1
## [28] cli_2.1.0 later_1.1.0.1 htmltools_0.5.0
## [31] tools_4.0.3 gtable_0.3.0 glue_1.4.2
## [34] GenomeInfoDbData_1.2.4 fastmatch_1.1-0 Rcpp_1.0.5
## [37] cellranger_1.1.0 vctrs_0.3.4 polylabelr_0.2.0
## [40] xfun_0.19 ps_1.4.0 testthat_3.0.0
## [43] rvest_0.3.6 mime_0.9 lifecycle_0.2.0
## [46] XML_3.99-0.5 zlibbioc_1.36.0 scales_1.1.1
## [49] hms_0.5.3 promises_1.1.1 RColorBrewer_1.1-2
## [52] yaml_2.2.1 memoise_1.1.0 gridExtra_2.3
## [55] reshape_0.8.8 stringi_1.5.3 RSQLite_2.2.1
## [58] highr_0.8 genefilter_1.72.0 desc_1.2.0
## [61] caTools_1.18.0 BiocParallel_1.24.1 rlang_0.4.8
## [64] pkgconfig_2.0.3 bitops_1.0-6 evaluate_0.14
## [67] lattice_0.20-41 labeling_0.4.2 htmlwidgets_1.5.2
## [70] bit_4.0.4 tidyselect_1.1.0 plyr_1.8.6
## [73] magrittr_1.5 R6_2.5.0 generics_0.1.0
## [76] DelayedArray_0.16.0 DBI_1.1.0 pillar_1.4.6
## [79] haven_2.3.1 withr_2.3.0 survival_3.2-7
## [82] RCurl_1.98-1.2 modelr_0.1.8 crayon_1.3.4
## [85] KernSmooth_2.23-18 rmarkdown_2.5 locfit_1.5-9.4
## [88] grid_4.0.3 readxl_1.3.1 data.table_1.13.2
## [91] blob_1.2.1 reprex_0.3.0 digest_0.6.27
## [94] xtable_1.8-4 httpuv_1.5.4 munsell_0.5.0END of report