Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2020-09-10
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## t0_v_pod pod_crp t0_crp
## A1BG 2.6192564 -0.3065476 -3.3462109
## A1BG-AS1 0.5230655 0.2667380 -0.1855420
## A1CF 0.5526173 -0.1889397 0.1865445
## A2M -3.3389616 -0.4487032 1.3466992
## A2M-AS1 -3.1580711 -0.9062206 0.8962988
## A2ML1 -0.3535245 1.1221162 1.9364758Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 21381 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8376 |
| num_profile_genes_not_in_sets | 13005 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt
| Gene sets metrics | |
|---|---|
| num_genesets | 2400 |
| num_genesets_excluded | 1040 |
| num_genesets_included | 1360 |
| t0_v_pod | pod_crp | t0_crp | Count | |
|---|---|---|---|---|
| 1 | -1 | -1 | -1 | 3715 |
| 2 | 0 | -1 | -1 | 1 |
| 3 | 1 | -1 | -1 | 754 |
| 4 | -1 | 1 | -1 | 796 |
| 5 | 1 | 1 | -1 | 3769 |
| 6 | -1 | -1 | 0 | 1 |
| 7 | -1 | -1 | 1 | 4991 |
| 8 | 1 | -1 | 1 | 671 |
| 9 | -1 | 0 | 1 | 1 |
| 10 | -1 | 1 | 1 | 2513 |
| 11 | 1 | 1 | 1 | 4169 |
Gene sets by sector
| s.t0_v_pod | s.pod_crp | s.t0_crp | Count | |
|---|---|---|---|---|
| 1 | -1 | -1 | -1 | 95 |
| 2 | 1 | -1 | -1 | 57 |
| 3 | -1 | 1 | -1 | 1 |
| 4 | 1 | 1 | -1 | 487 |
| 5 | -1 | -1 | 1 | 74 |
| 6 | 1 | -1 | 1 | 17 |
| 7 | -1 | 1 | 1 | 1 |
| 8 | 1 | 1 | 1 | 17 |
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 100 gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.t0_v_pod | s.pod_crp | s.t0_crp | p.t0_v_pod | p.pod_crp | p.t0_crp |
|---|---|---|---|---|---|---|---|---|---|---|
| IRAK4 deficiency (TLR2/4) | 10 | 7.50e-06 | 4.34e-05 | 1.250 | 0.89900 | 0.8680 | -0.0598 | 8.36e-07 | 1.99e-06 | 7.43e-01 |
| MyD88 deficiency (TLR2/4) | 10 | 7.50e-06 | 4.34e-05 | 1.250 | 0.89900 | 0.8680 | -0.0598 | 8.36e-07 | 1.99e-06 | 7.43e-01 |
| Peptide chain elongation | 88 | 9.12e-75 | 1.24e-72 | 1.150 | -0.28100 | -0.7690 | -0.8110 | 5.05e-06 | 7.95e-36 | 1.13e-39 |
| Eukaryotic Translation Elongation | 93 | 8.41e-79 | 1.91e-76 | 1.150 | -0.27300 | -0.7650 | -0.8090 | 5.39e-06 | 2.35e-37 | 1.20e-41 |
| Viral mRNA Translation | 88 | 9.81e-71 | 1.03e-68 | 1.110 | -0.26200 | -0.7450 | -0.7870 | 2.13e-05 | 1.06e-33 | 2.15e-37 |
| Selenocysteine synthesis | 92 | 9.10e-70 | 8.25e-68 | 1.100 | -0.29900 | -0.7480 | -0.7560 | 7.43e-07 | 2.21e-35 | 3.66e-36 |
| Formation of a pool of free 40S subunits | 100 | 9.21e-83 | 3.13e-80 | 1.090 | -0.20800 | -0.7430 | -0.7690 | 3.27e-04 | 7.09e-38 | 1.81e-40 |
| Eukaryotic Translation Termination | 92 | 4.20e-70 | 4.08e-68 | 1.090 | -0.26500 | -0.7320 | -0.7620 | 1.13e-05 | 5.45e-34 | 9.76e-37 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 12 | 3.03e-05 | 1.42e-04 | 1.080 | 0.78500 | 0.7260 | -0.1330 | 2.48e-06 | 1.34e-05 | 4.24e-01 |
| alpha-linolenic acid (ALA) metabolism | 12 | 3.03e-05 | 1.42e-04 | 1.080 | 0.78500 | 0.7260 | -0.1330 | 2.48e-06 | 1.34e-05 | 4.24e-01 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 2.04e-05 | 1.00e-04 | 1.080 | 0.67000 | 0.6640 | -0.5160 | 1.19e-04 | 1.36e-04 | 3.04e-03 |
| Hyaluronan uptake and degradation | 10 | 1.40e-04 | 5.48e-04 | 1.040 | 0.72900 | 0.5740 | -0.4710 | 6.53e-05 | 1.66e-03 | 9.90e-03 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 94 | 3.19e-66 | 2.55e-64 | 1.040 | -0.24400 | -0.7050 | -0.7240 | 4.23e-05 | 2.60e-32 | 6.14e-34 |
| Translocation of ZAP-70 to Immunological synapse | 24 | 1.27e-09 | 1.62e-08 | 1.030 | -0.74300 | -0.7050 | -0.0817 | 2.86e-10 | 2.27e-09 | 4.89e-01 |
| Uptake and function of anthrax toxins | 10 | 3.14e-04 | 1.10e-03 | 1.020 | 0.70400 | 0.6170 | -0.4030 | 1.17e-04 | 7.33e-04 | 2.74e-02 |
| Regulation of TLR by endogenous ligand | 11 | 2.54e-04 | 9.11e-04 | 1.000 | 0.74300 | 0.6450 | -0.2020 | 1.95e-05 | 2.14e-04 | 2.46e-01 |
| VLDLR internalisation and degradation | 11 | 9.65e-06 | 5.40e-05 | 0.987 | 0.46800 | 0.5390 | -0.6820 | 7.18e-03 | 1.96e-03 | 8.98e-05 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 110 | 6.80e-80 | 1.85e-77 | 0.987 | -0.14300 | -0.6760 | -0.7040 | 9.49e-03 | 1.43e-34 | 1.92e-37 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 111 | 4.93e-78 | 9.59e-76 | 0.972 | -0.14700 | -0.6710 | -0.6880 | 7.38e-03 | 2.12e-34 | 4.08e-36 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 100 | 2.15e-62 | 1.63e-60 | 0.969 | -0.22200 | -0.6690 | -0.6660 | 1.28e-04 | 5.65e-31 | 1.06e-30 |
| Advanced glycosylation endproduct receptor signaling | 12 | 9.21e-05 | 3.81e-04 | 0.968 | 0.65000 | 0.5420 | -0.4700 | 9.71e-05 | 1.14e-03 | 4.78e-03 |
| Cap-dependent Translation Initiation | 118 | 3.48e-76 | 5.26e-74 | 0.927 | -0.13200 | -0.6370 | -0.6610 | 1.35e-02 | 5.36e-33 | 1.74e-35 |
| Eukaryotic Translation Initiation | 118 | 3.48e-76 | 5.26e-74 | 0.927 | -0.13200 | -0.6370 | -0.6610 | 1.35e-02 | 5.36e-33 | 1.74e-35 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 1.55e-36 | 6.18e-35 | 0.922 | -0.08310 | -0.6620 | -0.6360 | 3.05e-01 | 2.68e-16 | 3.83e-15 |
| WNT5A-dependent internalization of FZD4 | 13 | 9.70e-06 | 5.41e-05 | 0.917 | 0.44900 | 0.5250 | -0.6030 | 5.07e-03 | 1.05e-03 | 1.68e-04 |
| Erythrocytes take up carbon dioxide and release oxygen | 11 | 1.11e-03 | 3.22e-03 | 0.895 | 0.68000 | 0.5270 | -0.2470 | 9.48e-05 | 2.48e-03 | 1.57e-01 |
| O2/CO2 exchange in erythrocytes | 11 | 1.11e-03 | 3.22e-03 | 0.895 | 0.68000 | 0.5270 | -0.2470 | 9.48e-05 | 2.48e-03 | 1.57e-01 |
| Retrograde neurotrophin signalling | 12 | 3.63e-04 | 1.25e-03 | 0.893 | 0.56600 | 0.5170 | -0.4570 | 6.80e-04 | 1.93e-03 | 6.11e-03 |
| RNA Polymerase I Promoter Opening | 19 | 8.92e-07 | 6.77e-06 | 0.886 | 0.61600 | 0.4120 | -0.4860 | 3.31e-06 | 1.89e-03 | 2.46e-04 |
| Selenoamino acid metabolism | 114 | 2.96e-56 | 1.92e-54 | 0.876 | -0.22800 | -0.6170 | -0.5790 | 2.52e-05 | 4.37e-30 | 1.11e-26 |
| Gap junction trafficking | 13 | 3.88e-04 | 1.32e-03 | 0.872 | 0.56400 | 0.5530 | -0.3700 | 4.32e-04 | 5.56e-04 | 2.11e-02 |
| SRP-dependent cotranslational protein targeting to membrane | 111 | 8.28e-60 | 5.63e-58 | 0.861 | -0.13400 | -0.5830 | -0.6200 | 1.48e-02 | 2.36e-26 | 1.27e-29 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 114 | 2.07e-55 | 1.17e-53 | 0.859 | -0.19500 | -0.5850 | -0.5970 | 3.16e-04 | 3.11e-27 | 2.66e-28 |
| Nonsense-Mediated Decay (NMD) | 114 | 2.07e-55 | 1.17e-53 | 0.859 | -0.19500 | -0.5850 | -0.5970 | 3.16e-04 | 3.11e-27 | 2.66e-28 |
| Unwinding of DNA | 12 | 1.63e-03 | 4.55e-03 | 0.854 | -0.63700 | -0.5680 | 0.0087 | 1.33e-04 | 6.52e-04 | 9.58e-01 |
| RHO GTPases Activate WASPs and WAVEs | 35 | 2.05e-09 | 2.58e-08 | 0.847 | 0.60800 | 0.5420 | -0.2320 | 4.76e-10 | 2.90e-08 | 1.78e-02 |
| RHO GTPases Activate NADPH Oxidases | 21 | 2.87e-06 | 1.87e-05 | 0.844 | 0.55900 | 0.4720 | -0.4220 | 9.31e-06 | 1.79e-04 | 8.25e-04 |
| Translation initiation complex formation | 58 | 2.43e-36 | 9.45e-35 | 0.829 | -0.02010 | -0.5820 | -0.5900 | 7.92e-01 | 1.77e-14 | 7.54e-15 |
| RHO GTPases Activate ROCKs | 18 | 8.92e-05 | 3.71e-04 | 0.824 | 0.54100 | 0.6210 | -0.0253 | 7.03e-05 | 5.02e-06 | 8.53e-01 |
| MET activates RAP1 and RAC1 | 10 | 6.15e-03 | 1.39e-02 | 0.824 | 0.53000 | 0.6060 | 0.1780 | 3.71e-03 | 9.10e-04 | 3.31e-01 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 59 | 1.34e-36 | 5.53e-35 | 0.821 | -0.00808 | -0.5680 | -0.5930 | 9.15e-01 | 4.24e-14 | 3.25e-15 |
| Ribosomal scanning and start codon recognition | 58 | 6.98e-35 | 2.50e-33 | 0.817 | -0.02510 | -0.5720 | -0.5830 | 7.41e-01 | 4.68e-14 | 1.57e-14 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 8.28e-04 | 2.51e-03 | 0.816 | 0.46900 | 0.4460 | -0.4970 | 4.91e-03 | 7.46e-03 | 2.88e-03 |
| Josephin domain DUBs | 10 | 8.95e-04 | 2.69e-03 | 0.815 | 0.47000 | 0.2270 | -0.6270 | 1.01e-02 | 2.14e-01 | 5.99e-04 |
| Influenza Viral RNA Transcription and Replication | 135 | 7.99e-56 | 4.94e-54 | 0.811 | -0.22500 | -0.5730 | -0.5290 | 6.45e-06 | 1.21e-30 | 2.39e-26 |
| PD-1 signaling | 28 | 4.90e-07 | 4.09e-06 | 0.811 | -0.57900 | -0.5620 | -0.0759 | 1.13e-07 | 2.60e-07 | 4.87e-01 |
| Neutrophil degranulation | 458 | 0.00e+00 | 0.00e+00 | 0.809 | 0.58600 | 0.4540 | -0.3260 | 0.00e+00 | 1.37e-62 | 5.89e-33 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 180 | 2.04e-68 | 1.73e-66 | 0.808 | -0.30600 | -0.6370 | -0.3910 | 1.30e-12 | 1.75e-49 | 1.36e-19 |
| rRNA processing in the nucleus and cytosol | 190 | 2.79e-71 | 3.17e-69 | 0.806 | -0.30700 | -0.6330 | -0.3930 | 2.77e-13 | 2.17e-51 | 9.47e-21 |
| Platelet sensitization by LDL | 16 | 6.33e-04 | 2.00e-03 | 0.798 | 0.55200 | 0.5660 | -0.1070 | 1.31e-04 | 8.90e-05 | 4.58e-01 |
| p130Cas linkage to MAPK signaling for integrins | 11 | 9.97e-04 | 2.96e-03 | 0.798 | 0.66600 | 0.3820 | -0.2180 | 1.32e-04 | 2.82e-02 | 2.11e-01 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | 10 | 1.12e-02 | 2.33e-02 | 0.797 | 0.52800 | 0.5770 | -0.1550 | 3.86e-03 | 1.58e-03 | 3.95e-01 |
| Hyaluronan metabolism | 13 | 1.12e-03 | 3.26e-03 | 0.795 | 0.51300 | 0.4290 | -0.4300 | 1.37e-03 | 7.41e-03 | 7.32e-03 |
| Detoxification of Reactive Oxygen Species | 32 | 3.13e-08 | 3.27e-07 | 0.792 | 0.56100 | 0.4360 | -0.3500 | 3.93e-08 | 1.93e-05 | 6.09e-04 |
| Insulin receptor recycling | 21 | 1.06e-05 | 5.76e-05 | 0.790 | 0.56800 | 0.4040 | -0.3710 | 6.47e-06 | 1.34e-03 | 3.26e-03 |
| Activation of the pre-replicative complex | 32 | 6.26e-08 | 6.35e-07 | 0.779 | -0.48200 | -0.6040 | 0.1050 | 2.37e-06 | 3.40e-09 | 3.04e-01 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 13 | 4.27e-03 | 1.02e-02 | 0.776 | 0.55500 | 0.5350 | -0.0839 | 5.28e-04 | 8.32e-04 | 6.01e-01 |
| ROS and RNS production in phagocytes | 31 | 1.40e-08 | 1.54e-07 | 0.775 | 0.59700 | 0.3710 | -0.3240 | 8.47e-09 | 3.46e-04 | 1.77e-03 |
| Signaling by Leptin | 10 | 8.24e-03 | 1.80e-02 | 0.768 | 0.56500 | 0.3880 | -0.3470 | 1.98e-03 | 3.37e-02 | 5.76e-02 |
| rRNA processing | 217 | 8.40e-73 | 1.04e-70 | 0.766 | -0.28900 | -0.5890 | -0.3940 | 2.16e-13 | 7.88e-51 | 1.25e-23 |
| DNA strand elongation | 32 | 6.40e-07 | 5.09e-06 | 0.762 | -0.52200 | -0.5550 | 0.0270 | 3.22e-07 | 5.52e-08 | 7.91e-01 |
| Dissolution of Fibrin Clot | 12 | 3.97e-03 | 9.69e-03 | 0.762 | 0.56600 | 0.4120 | -0.3010 | 6.87e-04 | 1.36e-02 | 7.08e-02 |
| Mucopolysaccharidoses | 11 | 6.38e-03 | 1.44e-02 | 0.751 | 0.45500 | 0.4420 | -0.4030 | 9.00e-03 | 1.12e-02 | 2.07e-02 |
| Spry regulation of FGF signaling | 16 | 3.98e-04 | 1.35e-03 | 0.749 | 0.47500 | 0.3720 | -0.4450 | 1.01e-03 | 1.01e-02 | 2.08e-03 |
| Pentose phosphate pathway | 13 | 2.23e-03 | 6.01e-03 | 0.748 | 0.48800 | 0.3750 | -0.4250 | 2.33e-03 | 1.91e-02 | 7.96e-03 |
| DNA methylation | 20 | 2.54e-05 | 1.22e-04 | 0.747 | 0.51700 | 0.3250 | -0.4310 | 6.35e-05 | 1.19e-02 | 8.36e-04 |
| COPI-independent Golgi-to-ER retrograde traffic | 33 | 4.56e-07 | 3.83e-06 | 0.745 | 0.56300 | 0.4640 | -0.1510 | 2.13e-08 | 3.98e-06 | 1.32e-01 |
| Formation of ATP by chemiosmotic coupling | 18 | 3.36e-07 | 2.93e-06 | 0.743 | 0.42700 | 0.0375 | -0.6070 | 1.71e-03 | 7.83e-01 | 8.20e-06 |
| Diseases associated with the TLR signaling cascade | 23 | 7.96e-05 | 3.35e-04 | 0.739 | 0.53400 | 0.4800 | -0.1770 | 9.12e-06 | 6.80e-05 | 1.43e-01 |
| Diseases of Immune System | 23 | 7.96e-05 | 3.35e-04 | 0.739 | 0.53400 | 0.4800 | -0.1770 | 9.12e-06 | 6.80e-05 | 1.43e-01 |
| Pre-NOTCH Processing in Golgi | 18 | 1.20e-04 | 4.80e-04 | 0.735 | 0.41100 | 0.4870 | -0.3670 | 2.57e-03 | 3.49e-04 | 7.01e-03 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 11 | 1.54e-02 | 3.05e-02 | 0.732 | 0.47600 | 0.5490 | -0.0880 | 6.29e-03 | 1.61e-03 | 6.13e-01 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 3.97e-03 | 9.69e-03 | 0.731 | 0.54900 | 0.4810 | 0.0291 | 3.74e-04 | 1.83e-03 | 8.51e-01 |
| Phosphorylation of CD3 and TCR zeta chains | 27 | 1.07e-05 | 5.80e-05 | 0.728 | -0.53700 | -0.4860 | -0.0775 | 1.39e-06 | 1.22e-05 | 4.86e-01 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 20 | 1.46e-04 | 5.66e-04 | 0.725 | 0.51300 | 0.3830 | -0.3420 | 7.17e-05 | 3.06e-03 | 8.08e-03 |
| Neurodegenerative Diseases | 20 | 1.46e-04 | 5.66e-04 | 0.725 | 0.51300 | 0.3830 | -0.3420 | 7.17e-05 | 3.06e-03 | 8.08e-03 |
| rRNA modification in the nucleus and cytosol | 59 | 8.26e-14 | 1.54e-12 | 0.722 | -0.39700 | -0.5840 | -0.1520 | 1.32e-07 | 8.38e-15 | 4.35e-02 |
| EGFR downregulation | 27 | 1.40e-06 | 9.99e-06 | 0.713 | 0.46000 | 0.2940 | -0.4590 | 3.48e-05 | 8.23e-03 | 3.69e-05 |
| Activation of ATR in response to replication stress | 36 | 2.43e-07 | 2.15e-06 | 0.713 | -0.45200 | -0.5160 | 0.1940 | 2.73e-06 | 8.15e-08 | 4.35e-02 |
| Lagging Strand Synthesis | 20 | 4.14e-04 | 1.40e-03 | 0.710 | -0.45200 | -0.5460 | 0.0380 | 4.65e-04 | 2.35e-05 | 7.69e-01 |
| Budding and maturation of HIV virion | 26 | 1.32e-05 | 6.96e-05 | 0.708 | 0.52500 | 0.3730 | -0.2930 | 3.50e-06 | 9.80e-04 | 9.75e-03 |
| Processive synthesis on the lagging strand | 15 | 3.33e-03 | 8.31e-03 | 0.700 | -0.43100 | -0.5520 | -0.0108 | 3.86e-03 | 2.14e-04 | 9.42e-01 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 12 | 8.69e-03 | 1.88e-02 | 0.700 | 0.52500 | 0.3610 | -0.2900 | 1.64e-03 | 3.06e-02 | 8.22e-02 |
| Influenza Infection | 154 | 8.65e-49 | 4.36e-47 | 0.699 | -0.18100 | -0.4990 | -0.4550 | 1.07e-04 | 1.06e-26 | 1.61e-22 |
| IRAK1 recruits IKK complex | 10 | 2.90e-02 | 5.22e-02 | 0.699 | 0.53300 | 0.4040 | -0.2030 | 3.52e-03 | 2.71e-02 | 2.67e-01 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 10 | 2.90e-02 | 5.22e-02 | 0.699 | 0.53300 | 0.4040 | -0.2030 | 3.52e-03 | 2.71e-02 | 2.67e-01 |
| Smooth Muscle Contraction | 31 | 2.08e-06 | 1.42e-05 | 0.698 | 0.49400 | 0.3690 | -0.3290 | 1.95e-06 | 3.81e-04 | 1.53e-03 |
| Signal transduction by L1 | 20 | 4.29e-04 | 1.44e-03 | 0.698 | 0.43800 | 0.5070 | -0.1940 | 6.90e-04 | 8.61e-05 | 1.32e-01 |
| Cargo concentration in the ER | 30 | 1.41e-05 | 7.42e-05 | 0.697 | 0.52000 | 0.4630 | -0.0357 | 8.05e-07 | 1.14e-05 | 7.35e-01 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 12 | 3.25e-03 | 8.12e-03 | 0.697 | 0.58100 | 0.3250 | -0.2080 | 4.97e-04 | 5.10e-02 | 2.12e-01 |
| Transferrin endocytosis and recycling | 26 | 2.18e-05 | 1.06e-04 | 0.696 | 0.50900 | 0.3700 | -0.2980 | 7.03e-06 | 1.09e-03 | 8.47e-03 |
| EPHB-mediated forward signaling | 32 | 8.88e-06 | 5.05e-05 | 0.696 | 0.50400 | 0.4750 | -0.0670 | 8.17e-07 | 3.24e-06 | 5.12e-01 |
| Nucleobase biosynthesis | 13 | 2.59e-03 | 6.78e-03 | 0.696 | -0.35600 | -0.5780 | -0.1520 | 2.63e-02 | 3.06e-04 | 3.43e-01 |
| AKT phosphorylates targets in the cytosol | 14 | 4.48e-03 | 1.07e-02 | 0.695 | 0.42700 | 0.4440 | -0.3220 | 5.63e-03 | 4.05e-03 | 3.68e-02 |
| GAB1 signalosome | 15 | 1.42e-03 | 4.03e-03 | 0.695 | 0.47100 | 0.3010 | -0.4130 | 1.59e-03 | 4.33e-02 | 5.58e-03 |
| MAP2K and MAPK activation | 34 | 1.53e-06 | 1.08e-05 | 0.694 | 0.51600 | 0.4050 | -0.2250 | 1.87e-07 | 4.36e-05 | 2.30e-02 |
| ERKs are inactivated | 13 | 6.96e-03 | 1.54e-02 | 0.694 | 0.43200 | 0.4100 | -0.3550 | 6.97e-03 | 1.04e-02 | 2.66e-02 |
| Signal regulatory protein family interactions | 12 | 7.77e-03 | 1.71e-02 | 0.689 | 0.40900 | 0.3430 | -0.4370 | 1.43e-02 | 3.96e-02 | 8.80e-03 |
| Prolonged ERK activation events | 13 | 1.33e-02 | 2.71e-02 | 0.687 | 0.45200 | 0.5140 | -0.0617 | 4.80e-03 | 1.32e-03 | 7.00e-01 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 29 | 1.02e-05 | 5.57e-05 | 0.687 | 0.51900 | 0.3810 | -0.2380 | 1.28e-06 | 3.82e-04 | 2.65e-02 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.t0_v_pod | s.pod_crp | s.t0_crp | p.t0_v_pod | p.pod_crp | p.t0_crp |
|---|---|---|---|---|---|---|---|---|---|---|
| IRAK4 deficiency (TLR2/4) | 10 | 7.50e-06 | 4.34e-05 | 1.2500 | 0.899000 | 0.868000 | -0.059800 | 8.36e-07 | 1.99e-06 | 7.43e-01 |
| MyD88 deficiency (TLR2/4) | 10 | 7.50e-06 | 4.34e-05 | 1.2500 | 0.899000 | 0.868000 | -0.059800 | 8.36e-07 | 1.99e-06 | 7.43e-01 |
| Peptide chain elongation | 88 | 9.12e-75 | 1.24e-72 | 1.1500 | -0.281000 | -0.769000 | -0.811000 | 5.05e-06 | 7.95e-36 | 1.13e-39 |
| Eukaryotic Translation Elongation | 93 | 8.41e-79 | 1.91e-76 | 1.1500 | -0.273000 | -0.765000 | -0.809000 | 5.39e-06 | 2.35e-37 | 1.20e-41 |
| Viral mRNA Translation | 88 | 9.81e-71 | 1.03e-68 | 1.1100 | -0.262000 | -0.745000 | -0.787000 | 2.13e-05 | 1.06e-33 | 2.15e-37 |
| Selenocysteine synthesis | 92 | 9.10e-70 | 8.25e-68 | 1.1000 | -0.299000 | -0.748000 | -0.756000 | 7.43e-07 | 2.21e-35 | 3.66e-36 |
| Formation of a pool of free 40S subunits | 100 | 9.21e-83 | 3.13e-80 | 1.0900 | -0.208000 | -0.743000 | -0.769000 | 3.27e-04 | 7.09e-38 | 1.81e-40 |
| Eukaryotic Translation Termination | 92 | 4.20e-70 | 4.08e-68 | 1.0900 | -0.265000 | -0.732000 | -0.762000 | 1.13e-05 | 5.45e-34 | 9.76e-37 |
| alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 12 | 3.03e-05 | 1.42e-04 | 1.0800 | 0.785000 | 0.726000 | -0.133000 | 2.48e-06 | 1.34e-05 | 4.24e-01 |
| alpha-linolenic acid (ALA) metabolism | 12 | 3.03e-05 | 1.42e-04 | 1.0800 | 0.785000 | 0.726000 | -0.133000 | 2.48e-06 | 1.34e-05 | 4.24e-01 |
| WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 11 | 2.04e-05 | 1.00e-04 | 1.0800 | 0.670000 | 0.664000 | -0.516000 | 1.19e-04 | 1.36e-04 | 3.04e-03 |
| Hyaluronan uptake and degradation | 10 | 1.40e-04 | 5.48e-04 | 1.0400 | 0.729000 | 0.574000 | -0.471000 | 6.53e-05 | 1.66e-03 | 9.90e-03 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 94 | 3.19e-66 | 2.55e-64 | 1.0400 | -0.244000 | -0.705000 | -0.724000 | 4.23e-05 | 2.60e-32 | 6.14e-34 |
| Translocation of ZAP-70 to Immunological synapse | 24 | 1.27e-09 | 1.62e-08 | 1.0300 | -0.743000 | -0.705000 | -0.081700 | 2.86e-10 | 2.27e-09 | 4.89e-01 |
| Uptake and function of anthrax toxins | 10 | 3.14e-04 | 1.10e-03 | 1.0200 | 0.704000 | 0.617000 | -0.403000 | 1.17e-04 | 7.33e-04 | 2.74e-02 |
| Regulation of TLR by endogenous ligand | 11 | 2.54e-04 | 9.11e-04 | 1.0000 | 0.743000 | 0.645000 | -0.202000 | 1.95e-05 | 2.14e-04 | 2.46e-01 |
| VLDLR internalisation and degradation | 11 | 9.65e-06 | 5.40e-05 | 0.9870 | 0.468000 | 0.539000 | -0.682000 | 7.18e-03 | 1.96e-03 | 8.98e-05 |
| L13a-mediated translational silencing of Ceruloplasmin expression | 110 | 6.80e-80 | 1.85e-77 | 0.9870 | -0.143000 | -0.676000 | -0.704000 | 9.49e-03 | 1.43e-34 | 1.92e-37 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | 111 | 4.93e-78 | 9.59e-76 | 0.9720 | -0.147000 | -0.671000 | -0.688000 | 7.38e-03 | 2.12e-34 | 4.08e-36 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | 100 | 2.15e-62 | 1.63e-60 | 0.9690 | -0.222000 | -0.669000 | -0.666000 | 1.28e-04 | 5.65e-31 | 1.06e-30 |
| Advanced glycosylation endproduct receptor signaling | 12 | 9.21e-05 | 3.81e-04 | 0.9680 | 0.650000 | 0.542000 | -0.470000 | 9.71e-05 | 1.14e-03 | 4.78e-03 |
| Cap-dependent Translation Initiation | 118 | 3.48e-76 | 5.26e-74 | 0.9270 | -0.132000 | -0.637000 | -0.661000 | 1.35e-02 | 5.36e-33 | 1.74e-35 |
| Eukaryotic Translation Initiation | 118 | 3.48e-76 | 5.26e-74 | 0.9270 | -0.132000 | -0.637000 | -0.661000 | 1.35e-02 | 5.36e-33 | 1.74e-35 |
| Formation of the ternary complex, and subsequently, the 43S complex | 51 | 1.55e-36 | 6.18e-35 | 0.9220 | -0.083100 | -0.662000 | -0.636000 | 3.05e-01 | 2.68e-16 | 3.83e-15 |
| WNT5A-dependent internalization of FZD4 | 13 | 9.70e-06 | 5.41e-05 | 0.9170 | 0.449000 | 0.525000 | -0.603000 | 5.07e-03 | 1.05e-03 | 1.68e-04 |
| Erythrocytes take up carbon dioxide and release oxygen | 11 | 1.11e-03 | 3.22e-03 | 0.8950 | 0.680000 | 0.527000 | -0.247000 | 9.48e-05 | 2.48e-03 | 1.57e-01 |
| O2/CO2 exchange in erythrocytes | 11 | 1.11e-03 | 3.22e-03 | 0.8950 | 0.680000 | 0.527000 | -0.247000 | 9.48e-05 | 2.48e-03 | 1.57e-01 |
| Retrograde neurotrophin signalling | 12 | 3.63e-04 | 1.25e-03 | 0.8930 | 0.566000 | 0.517000 | -0.457000 | 6.80e-04 | 1.93e-03 | 6.11e-03 |
| RNA Polymerase I Promoter Opening | 19 | 8.92e-07 | 6.77e-06 | 0.8860 | 0.616000 | 0.412000 | -0.486000 | 3.31e-06 | 1.89e-03 | 2.46e-04 |
| Selenoamino acid metabolism | 114 | 2.96e-56 | 1.92e-54 | 0.8760 | -0.228000 | -0.617000 | -0.579000 | 2.52e-05 | 4.37e-30 | 1.11e-26 |
| Gap junction trafficking | 13 | 3.88e-04 | 1.32e-03 | 0.8720 | 0.564000 | 0.553000 | -0.370000 | 4.32e-04 | 5.56e-04 | 2.11e-02 |
| SRP-dependent cotranslational protein targeting to membrane | 111 | 8.28e-60 | 5.63e-58 | 0.8610 | -0.134000 | -0.583000 | -0.620000 | 1.48e-02 | 2.36e-26 | 1.27e-29 |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 114 | 2.07e-55 | 1.17e-53 | 0.8590 | -0.195000 | -0.585000 | -0.597000 | 3.16e-04 | 3.11e-27 | 2.66e-28 |
| Nonsense-Mediated Decay (NMD) | 114 | 2.07e-55 | 1.17e-53 | 0.8590 | -0.195000 | -0.585000 | -0.597000 | 3.16e-04 | 3.11e-27 | 2.66e-28 |
| Unwinding of DNA | 12 | 1.63e-03 | 4.55e-03 | 0.8540 | -0.637000 | -0.568000 | 0.008700 | 1.33e-04 | 6.52e-04 | 9.58e-01 |
| RHO GTPases Activate WASPs and WAVEs | 35 | 2.05e-09 | 2.58e-08 | 0.8470 | 0.608000 | 0.542000 | -0.232000 | 4.76e-10 | 2.90e-08 | 1.78e-02 |
| RHO GTPases Activate NADPH Oxidases | 21 | 2.87e-06 | 1.87e-05 | 0.8440 | 0.559000 | 0.472000 | -0.422000 | 9.31e-06 | 1.79e-04 | 8.25e-04 |
| Translation initiation complex formation | 58 | 2.43e-36 | 9.45e-35 | 0.8290 | -0.020100 | -0.582000 | -0.590000 | 7.92e-01 | 1.77e-14 | 7.54e-15 |
| RHO GTPases Activate ROCKs | 18 | 8.92e-05 | 3.71e-04 | 0.8240 | 0.541000 | 0.621000 | -0.025300 | 7.03e-05 | 5.02e-06 | 8.53e-01 |
| MET activates RAP1 and RAC1 | 10 | 6.15e-03 | 1.39e-02 | 0.8240 | 0.530000 | 0.606000 | 0.178000 | 3.71e-03 | 9.10e-04 | 3.31e-01 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | 59 | 1.34e-36 | 5.53e-35 | 0.8210 | -0.008080 | -0.568000 | -0.593000 | 9.15e-01 | 4.24e-14 | 3.25e-15 |
| Ribosomal scanning and start codon recognition | 58 | 6.98e-35 | 2.50e-33 | 0.8170 | -0.025100 | -0.572000 | -0.583000 | 7.41e-01 | 4.68e-14 | 1.57e-14 |
| Trafficking of GluR2-containing AMPA receptors | 12 | 8.28e-04 | 2.51e-03 | 0.8160 | 0.469000 | 0.446000 | -0.497000 | 4.91e-03 | 7.46e-03 | 2.88e-03 |
| Josephin domain DUBs | 10 | 8.95e-04 | 2.69e-03 | 0.8150 | 0.470000 | 0.227000 | -0.627000 | 1.01e-02 | 2.14e-01 | 5.99e-04 |
| Influenza Viral RNA Transcription and Replication | 135 | 7.99e-56 | 4.94e-54 | 0.8110 | -0.225000 | -0.573000 | -0.529000 | 6.45e-06 | 1.21e-30 | 2.39e-26 |
| PD-1 signaling | 28 | 4.90e-07 | 4.09e-06 | 0.8110 | -0.579000 | -0.562000 | -0.075900 | 1.13e-07 | 2.60e-07 | 4.87e-01 |
| Neutrophil degranulation | 458 | 1.10e-119 | 1.50e-116 | 0.8090 | 0.586000 | 0.454000 | -0.326000 | 2.13e-103 | 1.37e-62 | 5.89e-33 |
| Major pathway of rRNA processing in the nucleolus and cytosol | 180 | 2.04e-68 | 1.73e-66 | 0.8080 | -0.306000 | -0.637000 | -0.391000 | 1.30e-12 | 1.75e-49 | 1.36e-19 |
| rRNA processing in the nucleus and cytosol | 190 | 2.79e-71 | 3.17e-69 | 0.8060 | -0.307000 | -0.633000 | -0.393000 | 2.77e-13 | 2.17e-51 | 9.47e-21 |
| Platelet sensitization by LDL | 16 | 6.33e-04 | 2.00e-03 | 0.7980 | 0.552000 | 0.566000 | -0.107000 | 1.31e-04 | 8.90e-05 | 4.58e-01 |
| p130Cas linkage to MAPK signaling for integrins | 11 | 9.97e-04 | 2.96e-03 | 0.7980 | 0.666000 | 0.382000 | -0.218000 | 1.32e-04 | 2.82e-02 | 2.11e-01 |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | 10 | 1.12e-02 | 2.33e-02 | 0.7970 | 0.528000 | 0.577000 | -0.155000 | 3.86e-03 | 1.58e-03 | 3.95e-01 |
| Hyaluronan metabolism | 13 | 1.12e-03 | 3.26e-03 | 0.7950 | 0.513000 | 0.429000 | -0.430000 | 1.37e-03 | 7.41e-03 | 7.32e-03 |
| Detoxification of Reactive Oxygen Species | 32 | 3.13e-08 | 3.27e-07 | 0.7920 | 0.561000 | 0.436000 | -0.350000 | 3.93e-08 | 1.93e-05 | 6.09e-04 |
| Insulin receptor recycling | 21 | 1.06e-05 | 5.76e-05 | 0.7900 | 0.568000 | 0.404000 | -0.371000 | 6.47e-06 | 1.34e-03 | 3.26e-03 |
| Activation of the pre-replicative complex | 32 | 6.26e-08 | 6.35e-07 | 0.7790 | -0.482000 | -0.604000 | 0.105000 | 2.37e-06 | 3.40e-09 | 3.04e-01 |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | 13 | 4.27e-03 | 1.02e-02 | 0.7760 | 0.555000 | 0.535000 | -0.083900 | 5.28e-04 | 8.32e-04 | 6.01e-01 |
| ROS and RNS production in phagocytes | 31 | 1.40e-08 | 1.54e-07 | 0.7750 | 0.597000 | 0.371000 | -0.324000 | 8.47e-09 | 3.46e-04 | 1.77e-03 |
| Signaling by Leptin | 10 | 8.24e-03 | 1.80e-02 | 0.7680 | 0.565000 | 0.388000 | -0.347000 | 1.98e-03 | 3.37e-02 | 5.76e-02 |
| rRNA processing | 217 | 8.40e-73 | 1.04e-70 | 0.7660 | -0.289000 | -0.589000 | -0.394000 | 2.16e-13 | 7.88e-51 | 1.25e-23 |
| DNA strand elongation | 32 | 6.40e-07 | 5.09e-06 | 0.7620 | -0.522000 | -0.555000 | 0.027000 | 3.22e-07 | 5.52e-08 | 7.91e-01 |
| Dissolution of Fibrin Clot | 12 | 3.97e-03 | 9.69e-03 | 0.7620 | 0.566000 | 0.412000 | -0.301000 | 6.87e-04 | 1.36e-02 | 7.08e-02 |
| Mucopolysaccharidoses | 11 | 6.38e-03 | 1.44e-02 | 0.7510 | 0.455000 | 0.442000 | -0.403000 | 9.00e-03 | 1.12e-02 | 2.07e-02 |
| Spry regulation of FGF signaling | 16 | 3.98e-04 | 1.35e-03 | 0.7490 | 0.475000 | 0.372000 | -0.445000 | 1.01e-03 | 1.01e-02 | 2.08e-03 |
| Pentose phosphate pathway | 13 | 2.23e-03 | 6.01e-03 | 0.7480 | 0.488000 | 0.375000 | -0.425000 | 2.33e-03 | 1.91e-02 | 7.96e-03 |
| DNA methylation | 20 | 2.54e-05 | 1.22e-04 | 0.7470 | 0.517000 | 0.325000 | -0.431000 | 6.35e-05 | 1.19e-02 | 8.36e-04 |
| COPI-independent Golgi-to-ER retrograde traffic | 33 | 4.56e-07 | 3.83e-06 | 0.7450 | 0.563000 | 0.464000 | -0.151000 | 2.13e-08 | 3.98e-06 | 1.32e-01 |
| Formation of ATP by chemiosmotic coupling | 18 | 3.36e-07 | 2.93e-06 | 0.7430 | 0.427000 | 0.037500 | -0.607000 | 1.71e-03 | 7.83e-01 | 8.20e-06 |
| Diseases associated with the TLR signaling cascade | 23 | 7.96e-05 | 3.35e-04 | 0.7390 | 0.534000 | 0.480000 | -0.177000 | 9.12e-06 | 6.80e-05 | 1.43e-01 |
| Diseases of Immune System | 23 | 7.96e-05 | 3.35e-04 | 0.7390 | 0.534000 | 0.480000 | -0.177000 | 9.12e-06 | 6.80e-05 | 1.43e-01 |
| Pre-NOTCH Processing in Golgi | 18 | 1.20e-04 | 4.80e-04 | 0.7350 | 0.411000 | 0.487000 | -0.367000 | 2.57e-03 | 3.49e-04 | 7.01e-03 |
| Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 11 | 1.54e-02 | 3.05e-02 | 0.7320 | 0.476000 | 0.549000 | -0.088000 | 6.29e-03 | 1.61e-03 | 6.13e-01 |
| Golgi Cisternae Pericentriolar Stack Reorganization | 14 | 3.97e-03 | 9.69e-03 | 0.7310 | 0.549000 | 0.481000 | 0.029100 | 3.74e-04 | 1.83e-03 | 8.51e-01 |
| Phosphorylation of CD3 and TCR zeta chains | 27 | 1.07e-05 | 5.80e-05 | 0.7280 | -0.537000 | -0.486000 | -0.077500 | 1.39e-06 | 1.22e-05 | 4.86e-01 |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | 20 | 1.46e-04 | 5.66e-04 | 0.7250 | 0.513000 | 0.383000 | -0.342000 | 7.17e-05 | 3.06e-03 | 8.08e-03 |
| Neurodegenerative Diseases | 20 | 1.46e-04 | 5.66e-04 | 0.7250 | 0.513000 | 0.383000 | -0.342000 | 7.17e-05 | 3.06e-03 | 8.08e-03 |
| rRNA modification in the nucleus and cytosol | 59 | 8.26e-14 | 1.54e-12 | 0.7220 | -0.397000 | -0.584000 | -0.152000 | 1.32e-07 | 8.38e-15 | 4.35e-02 |
| EGFR downregulation | 27 | 1.40e-06 | 9.99e-06 | 0.7130 | 0.460000 | 0.294000 | -0.459000 | 3.48e-05 | 8.23e-03 | 3.69e-05 |
| Activation of ATR in response to replication stress | 36 | 2.43e-07 | 2.15e-06 | 0.7130 | -0.452000 | -0.516000 | 0.194000 | 2.73e-06 | 8.15e-08 | 4.35e-02 |
| Lagging Strand Synthesis | 20 | 4.14e-04 | 1.40e-03 | 0.7100 | -0.452000 | -0.546000 | 0.038000 | 4.65e-04 | 2.35e-05 | 7.69e-01 |
| Budding and maturation of HIV virion | 26 | 1.32e-05 | 6.96e-05 | 0.7080 | 0.525000 | 0.373000 | -0.293000 | 3.50e-06 | 9.80e-04 | 9.75e-03 |
| Processive synthesis on the lagging strand | 15 | 3.33e-03 | 8.31e-03 | 0.7000 | -0.431000 | -0.552000 | -0.010800 | 3.86e-03 | 2.14e-04 | 9.42e-01 |
| InlB-mediated entry of Listeria monocytogenes into host cell | 12 | 8.69e-03 | 1.88e-02 | 0.7000 | 0.525000 | 0.361000 | -0.290000 | 1.64e-03 | 3.06e-02 | 8.22e-02 |
| Influenza Infection | 154 | 8.65e-49 | 4.36e-47 | 0.6990 | -0.181000 | -0.499000 | -0.455000 | 1.07e-04 | 1.06e-26 | 1.61e-22 |
| IRAK1 recruits IKK complex | 10 | 2.90e-02 | 5.22e-02 | 0.6990 | 0.533000 | 0.404000 | -0.203000 | 3.52e-03 | 2.71e-02 | 2.67e-01 |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 10 | 2.90e-02 | 5.22e-02 | 0.6990 | 0.533000 | 0.404000 | -0.203000 | 3.52e-03 | 2.71e-02 | 2.67e-01 |
| Smooth Muscle Contraction | 31 | 2.08e-06 | 1.42e-05 | 0.6980 | 0.494000 | 0.369000 | -0.329000 | 1.95e-06 | 3.81e-04 | 1.53e-03 |
| Signal transduction by L1 | 20 | 4.29e-04 | 1.44e-03 | 0.6980 | 0.438000 | 0.507000 | -0.194000 | 6.90e-04 | 8.61e-05 | 1.32e-01 |
| Cargo concentration in the ER | 30 | 1.41e-05 | 7.42e-05 | 0.6970 | 0.520000 | 0.463000 | -0.035700 | 8.05e-07 | 1.14e-05 | 7.35e-01 |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | 12 | 3.25e-03 | 8.12e-03 | 0.6970 | 0.581000 | 0.325000 | -0.208000 | 4.97e-04 | 5.10e-02 | 2.12e-01 |
| Transferrin endocytosis and recycling | 26 | 2.18e-05 | 1.06e-04 | 0.6960 | 0.509000 | 0.370000 | -0.298000 | 7.03e-06 | 1.09e-03 | 8.47e-03 |
| EPHB-mediated forward signaling | 32 | 8.88e-06 | 5.05e-05 | 0.6960 | 0.504000 | 0.475000 | -0.067000 | 8.17e-07 | 3.24e-06 | 5.12e-01 |
| Nucleobase biosynthesis | 13 | 2.59e-03 | 6.78e-03 | 0.6960 | -0.356000 | -0.578000 | -0.152000 | 2.63e-02 | 3.06e-04 | 3.43e-01 |
| AKT phosphorylates targets in the cytosol | 14 | 4.48e-03 | 1.07e-02 | 0.6950 | 0.427000 | 0.444000 | -0.322000 | 5.63e-03 | 4.05e-03 | 3.68e-02 |
| GAB1 signalosome | 15 | 1.42e-03 | 4.03e-03 | 0.6950 | 0.471000 | 0.301000 | -0.413000 | 1.59e-03 | 4.33e-02 | 5.58e-03 |
| MAP2K and MAPK activation | 34 | 1.53e-06 | 1.08e-05 | 0.6940 | 0.516000 | 0.405000 | -0.225000 | 1.87e-07 | 4.36e-05 | 2.30e-02 |
| ERKs are inactivated | 13 | 6.96e-03 | 1.54e-02 | 0.6940 | 0.432000 | 0.410000 | -0.355000 | 6.97e-03 | 1.04e-02 | 2.66e-02 |
| Signal regulatory protein family interactions | 12 | 7.77e-03 | 1.71e-02 | 0.6890 | 0.409000 | 0.343000 | -0.437000 | 1.43e-02 | 3.96e-02 | 8.80e-03 |
| Prolonged ERK activation events | 13 | 1.33e-02 | 2.71e-02 | 0.6870 | 0.452000 | 0.514000 | -0.061700 | 4.80e-03 | 1.32e-03 | 7.00e-01 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | 29 | 1.02e-05 | 5.57e-05 | 0.6870 | 0.519000 | 0.381000 | -0.238000 | 1.28e-06 | 3.82e-04 | 2.65e-02 |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 24 | 1.81e-04 | 6.80e-04 | 0.6840 | -0.445000 | -0.513000 | -0.073800 | 1.59e-04 | 1.33e-05 | 5.32e-01 |
| Negative regulation of MET activity | 18 | 1.69e-03 | 4.71e-03 | 0.6830 | 0.526000 | 0.415000 | -0.134000 | 1.12e-04 | 2.27e-03 | 3.27e-01 |
| PCNA-Dependent Long Patch Base Excision Repair | 21 | 3.97e-04 | 1.35e-03 | 0.6830 | -0.420000 | -0.528000 | -0.109000 | 8.64e-04 | 2.81e-05 | 3.89e-01 |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | 22 | 2.54e-04 | 9.11e-04 | 0.6790 | 0.471000 | 0.372000 | -0.316000 | 1.32e-04 | 2.50e-03 | 1.02e-02 |
| Glycogen synthesis | 13 | 3.11e-03 | 7.84e-03 | 0.6770 | 0.404000 | 0.235000 | -0.490000 | 1.17e-02 | 1.43e-01 | 2.21e-03 |
| Assembly Of The HIV Virion | 15 | 1.33e-03 | 3.82e-03 | 0.6770 | 0.417000 | 0.250000 | -0.471000 | 5.12e-03 | 9.42e-02 | 1.59e-03 |
| Generation of second messenger molecules | 38 | 1.05e-06 | 7.82e-06 | 0.6750 | -0.464000 | -0.479000 | -0.101000 | 7.22e-07 | 3.12e-07 | 2.82e-01 |
| SUMOylation of immune response proteins | 11 | 1.34e-02 | 2.73e-02 | 0.6720 | 0.408000 | 0.290000 | -0.448000 | 1.92e-02 | 9.57e-02 | 1.00e-02 |
| Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) | 12 | 1.08e-02 | 2.25e-02 | 0.6720 | 0.478000 | 0.317000 | -0.350000 | 4.12e-03 | 5.75e-02 | 3.59e-02 |
| Diseases of hemostasis | 12 | 1.08e-02 | 2.25e-02 | 0.6720 | 0.478000 | 0.317000 | -0.350000 | 4.12e-03 | 5.75e-02 | 3.59e-02 |
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 11 | 3.16e-02 | 5.61e-02 | 0.6710 | 0.443000 | 0.452000 | -0.223000 | 1.10e-02 | 9.41e-03 | 2.01e-01 |
| Signaling by high-kinase activity BRAF mutants | 31 | 1.48e-05 | 7.70e-05 | 0.6680 | 0.498000 | 0.391000 | -0.211000 | 1.59e-06 | 1.62e-04 | 4.20e-02 |
| RHO GTPases activate PKNs | 47 | 7.83e-08 | 7.71e-07 | 0.6670 | 0.480000 | 0.430000 | -0.170000 | 1.24e-08 | 3.30e-07 | 4.44e-02 |
| Gap junction trafficking and regulation | 15 | 5.29e-03 | 1.22e-02 | 0.6660 | 0.414000 | 0.431000 | -0.296000 | 5.54e-03 | 3.88e-03 | 4.74e-02 |
| RHO GTPases activate PAKs | 20 | 1.81e-03 | 5.00e-03 | 0.6660 | 0.484000 | 0.454000 | -0.055600 | 1.78e-04 | 4.44e-04 | 6.67e-01 |
| Platelet Aggregation (Plug Formation) | 28 | 2.71e-05 | 1.29e-04 | 0.6620 | 0.476000 | 0.346000 | -0.303000 | 1.29e-05 | 1.52e-03 | 5.46e-03 |
| Erythropoietin activates RAS | 13 | 1.73e-02 | 3.34e-02 | 0.6610 | 0.423000 | 0.506000 | -0.045600 | 8.22e-03 | 1.59e-03 | 7.76e-01 |
| Membrane binding and targetting of GAG proteins | 13 | 5.54e-03 | 1.27e-02 | 0.6610 | 0.445000 | 0.266000 | -0.410000 | 5.43e-03 | 9.74e-02 | 1.05e-02 |
| Synthesis And Processing Of GAG, GAGPOL Polyproteins | 13 | 5.54e-03 | 1.27e-02 | 0.6610 | 0.445000 | 0.266000 | -0.410000 | 5.43e-03 | 9.74e-02 | 1.05e-02 |
| Removal of the Flap Intermediate | 14 | 8.94e-03 | 1.93e-02 | 0.6590 | -0.399000 | -0.525000 | 0.009800 | 9.75e-03 | 6.78e-04 | 9.49e-01 |
| Amyloid fiber formation | 51 | 8.44e-11 | 1.18e-09 | 0.6590 | 0.482000 | 0.273000 | -0.357000 | 2.59e-09 | 7.54e-04 | 1.06e-05 |
| Heme degradation | 10 | 4.25e-02 | 7.19e-02 | 0.6550 | 0.401000 | 0.483000 | -0.185000 | 2.80e-02 | 8.20e-03 | 3.10e-01 |
| RHO GTPases activate IQGAPs | 11 | 4.31e-02 | 7.28e-02 | 0.6530 | 0.434000 | 0.476000 | -0.107000 | 1.27e-02 | 6.24e-03 | 5.39e-01 |
| Diseases of programmed cell death | 22 | 2.57e-04 | 9.17e-04 | 0.6500 | 0.452000 | 0.305000 | -0.353000 | 2.39e-04 | 1.34e-02 | 4.17e-03 |
| Recycling pathway of L1 | 26 | 2.17e-04 | 7.99e-04 | 0.6450 | 0.426000 | 0.419000 | -0.242000 | 1.70e-04 | 2.13e-04 | 3.27e-02 |
| Response of Mtb to phagocytosis | 22 | 2.26e-04 | 8.25e-04 | 0.6430 | 0.459000 | 0.287000 | -0.348000 | 1.96e-04 | 1.99e-02 | 4.77e-03 |
| GP1b-IX-V activation signalling | 10 | 1.36e-02 | 2.75e-02 | 0.6420 | 0.357000 | 0.147000 | -0.512000 | 5.07e-02 | 4.21e-01 | 5.01e-03 |
| Late endosomal microautophagy | 30 | 1.16e-05 | 6.21e-05 | 0.6370 | 0.423000 | 0.286000 | -0.382000 | 6.12e-05 | 6.66e-03 | 2.95e-04 |
| Regulation of expression of SLITs and ROBOs | 159 | 2.51e-48 | 1.22e-46 | 0.6370 | -0.041600 | -0.379000 | -0.511000 | 3.65e-01 | 1.50e-16 | 9.36e-29 |
| FOXO-mediated transcription of cell death genes | 16 | 2.19e-03 | 5.91e-03 | 0.6370 | 0.332000 | 0.356000 | -0.411000 | 2.15e-02 | 1.37e-02 | 4.43e-03 |
| Pexophagy | 11 | 5.58e-03 | 1.28e-02 | 0.6350 | 0.357000 | 0.098400 | -0.517000 | 4.06e-02 | 5.72e-01 | 3.00e-03 |
| PKA activation in glucagon signalling | 14 | 6.21e-03 | 1.40e-02 | 0.6350 | 0.345000 | 0.313000 | -0.432000 | 2.53e-02 | 4.25e-02 | 5.17e-03 |
| Integrin signaling | 22 | 1.46e-03 | 4.13e-03 | 0.6350 | 0.456000 | 0.400000 | -0.187000 | 2.10e-04 | 1.15e-03 | 1.30e-01 |
| Sealing of the nuclear envelope (NE) by ESCRT-III | 25 | 4.28e-04 | 1.44e-03 | 0.6320 | 0.431000 | 0.382000 | -0.258000 | 1.88e-04 | 9.33e-04 | 2.57e-02 |
| Packaging Of Telomere Ends | 20 | 3.46e-04 | 1.20e-03 | 0.6300 | 0.448000 | 0.240000 | -0.373000 | 5.29e-04 | 6.31e-02 | 3.88e-03 |
| Suppression of phagosomal maturation | 12 | 2.05e-02 | 3.92e-02 | 0.6290 | 0.437000 | 0.296000 | -0.343000 | 8.73e-03 | 7.56e-02 | 3.99e-02 |
| Telomere C-strand (Lagging Strand) Synthesis | 34 | 1.61e-05 | 8.34e-05 | 0.6290 | -0.387000 | -0.490000 | -0.074800 | 9.40e-05 | 7.66e-07 | 4.51e-01 |
| Sema4D in semaphorin signaling | 22 | 7.32e-04 | 2.26e-03 | 0.6280 | 0.379000 | 0.473000 | -0.167000 | 2.09e-03 | 1.23e-04 | 1.76e-01 |
| Collagen degradation | 28 | 9.53e-05 | 3.93e-04 | 0.6260 | 0.394000 | 0.362000 | -0.325000 | 3.10e-04 | 9.04e-04 | 2.96e-03 |
| Diseases of carbohydrate metabolism | 29 | 9.96e-06 | 5.51e-05 | 0.6250 | 0.333000 | 0.243000 | -0.469000 | 1.93e-03 | 2.35e-02 | 1.21e-05 |
| Signaling by RAF1 mutants | 34 | 2.45e-05 | 1.18e-04 | 0.6240 | 0.471000 | 0.368000 | -0.181000 | 2.03e-06 | 2.06e-04 | 6.77e-02 |
| Glycogen storage diseases | 13 | 6.64e-03 | 1.48e-02 | 0.6230 | 0.301000 | 0.200000 | -0.507000 | 6.04e-02 | 2.12e-01 | 1.54e-03 |
| Lysosome Vesicle Biogenesis | 32 | 1.84e-05 | 9.36e-05 | 0.6210 | 0.404000 | 0.315000 | -0.351000 | 7.55e-05 | 2.06e-03 | 5.78e-04 |
| Sema4D induced cell migration and growth-cone collapse | 19 | 2.59e-03 | 6.78e-03 | 0.6210 | 0.375000 | 0.463000 | -0.176000 | 4.64e-03 | 4.81e-04 | 1.85e-01 |
| Response to elevated platelet cytosolic Ca2+ | 108 | 8.64e-19 | 2.10e-17 | 0.6210 | 0.453000 | 0.288000 | -0.311000 | 3.81e-16 | 2.32e-07 | 2.23e-08 |
| RHO GTPases activate CIT | 18 | 3.74e-03 | 9.17e-03 | 0.6190 | 0.369000 | 0.496000 | -0.028800 | 6.79e-03 | 2.67e-04 | 8.32e-01 |
| Regulated proteolysis of p75NTR | 11 | 6.47e-02 | 1.04e-01 | 0.6190 | 0.416000 | 0.449000 | -0.088400 | 1.69e-02 | 9.86e-03 | 6.12e-01 |
| Platelet degranulation | 104 | 3.89e-18 | 8.97e-17 | 0.6190 | 0.451000 | 0.283000 | -0.315000 | 1.74e-15 | 6.21e-07 | 2.90e-08 |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 16 | 1.09e-03 | 3.18e-03 | 0.6190 | 0.304000 | 0.121000 | -0.525000 | 3.50e-02 | 4.01e-01 | 2.78e-04 |
| Common Pathway of Fibrin Clot Formation | 14 | 8.66e-03 | 1.88e-02 | 0.6160 | 0.335000 | 0.304000 | -0.419000 | 2.99e-02 | 4.92e-02 | 6.62e-03 |
| Notch-HLH transcription pathway | 28 | 2.17e-04 | 7.99e-04 | 0.6090 | 0.407000 | 0.347000 | -0.291000 | 1.92e-04 | 1.50e-03 | 7.71e-03 |
| Signaling by Erythropoietin | 24 | 9.01e-04 | 2.70e-03 | 0.6070 | 0.377000 | 0.458000 | -0.127000 | 1.38e-03 | 1.04e-04 | 2.80e-01 |
| Glycogen breakdown (glycogenolysis) | 13 | 3.72e-02 | 6.46e-02 | 0.6040 | 0.410000 | 0.379000 | -0.229000 | 1.04e-02 | 1.80e-02 | 1.53e-01 |
| Infection with Mycobacterium tuberculosis | 26 | 1.04e-04 | 4.23e-04 | 0.6030 | 0.449000 | 0.260000 | -0.307000 | 7.40e-05 | 2.19e-02 | 6.68e-03 |
| Frs2-mediated activation | 11 | 6.31e-02 | 1.02e-01 | 0.6000 | 0.377000 | 0.452000 | -0.115000 | 3.02e-02 | 9.39e-03 | 5.07e-01 |
| Chondroitin sulfate biosynthesis | 12 | 1.50e-02 | 2.99e-02 | 0.6000 | 0.296000 | 0.387000 | -0.351000 | 7.61e-02 | 2.04e-02 | 3.52e-02 |
| EPH-Ephrin signaling | 78 | 3.69e-11 | 5.46e-10 | 0.6000 | 0.399000 | 0.362000 | -0.264000 | 1.13e-09 | 3.14e-08 | 5.60e-05 |
| GPVI-mediated activation cascade | 31 | 1.87e-05 | 9.48e-05 | 0.5990 | 0.329000 | 0.454000 | -0.209000 | 1.52e-03 | 1.19e-05 | 4.39e-02 |
| NF-kB is activated and signals survival | 12 | 1.02e-02 | 2.17e-02 | 0.5990 | 0.264000 | 0.112000 | -0.525000 | 1.14e-01 | 5.00e-01 | 1.62e-03 |
| MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 92 | 4.40e-14 | 8.32e-13 | 0.5940 | 0.438000 | 0.296000 | -0.270000 | 3.52e-13 | 9.52e-07 | 7.46e-06 |
| Toll Like Receptor 2 (TLR2) Cascade | 92 | 4.40e-14 | 8.32e-13 | 0.5940 | 0.438000 | 0.296000 | -0.270000 | 3.52e-13 | 9.52e-07 | 7.46e-06 |
| Toll Like Receptor TLR1:TLR2 Cascade | 92 | 4.40e-14 | 8.32e-13 | 0.5940 | 0.438000 | 0.296000 | -0.270000 | 3.52e-13 | 9.52e-07 | 7.46e-06 |
| Toll Like Receptor TLR6:TLR2 Cascade | 92 | 4.40e-14 | 8.32e-13 | 0.5940 | 0.438000 | 0.296000 | -0.270000 | 3.52e-13 | 9.52e-07 | 7.46e-06 |
| SHC1 events in EGFR signaling | 12 | 2.13e-02 | 4.05e-02 | 0.5940 | 0.480000 | 0.272000 | -0.219000 | 4.00e-03 | 1.02e-01 | 1.88e-01 |
| Regulation of IFNG signaling | 14 | 3.12e-02 | 5.54e-02 | 0.5940 | 0.396000 | 0.427000 | 0.115000 | 1.03e-02 | 5.65e-03 | 4.56e-01 |
| Platelet Adhesion to exposed collagen | 13 | 4.20e-03 | 1.01e-02 | 0.5930 | 0.500000 | 0.211000 | -0.239000 | 1.80e-03 | 1.87e-01 | 1.36e-01 |
| Pyrimidine salvage | 10 | 6.54e-02 | 1.05e-01 | 0.5920 | 0.345000 | 0.330000 | -0.350000 | 5.90e-02 | 7.07e-02 | 5.54e-02 |
| Antimicrobial peptides | 33 | 2.58e-11 | 4.18e-10 | 0.5900 | 0.459000 | 0.019900 | -0.371000 | 5.09e-06 | 8.43e-01 | 2.27e-04 |
| Telomere C-strand synthesis initiation | 13 | 3.74e-02 | 6.49e-02 | 0.5900 | -0.361000 | -0.464000 | -0.056700 | 2.43e-02 | 3.81e-03 | 7.23e-01 |
| activated TAK1 mediates p38 MAPK activation | 19 | 7.06e-03 | 1.56e-02 | 0.5870 | 0.455000 | 0.346000 | -0.135000 | 5.93e-04 | 9.06e-03 | 3.07e-01 |
| GRB2 events in EGFR signaling | 11 | 1.85e-02 | 3.56e-02 | 0.5870 | 0.477000 | 0.222000 | -0.261000 | 6.15e-03 | 2.03e-01 | 1.34e-01 |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 22 | 2.93e-04 | 1.03e-03 | 0.5830 | 0.367000 | 0.166000 | -0.422000 | 2.88e-03 | 1.78e-01 | 6.16e-04 |
| Purine ribonucleoside monophosphate biosynthesis | 10 | 3.06e-02 | 5.46e-02 | 0.5830 | -0.266000 | -0.505000 | -0.121000 | 1.46e-01 | 5.70e-03 | 5.09e-01 |
| Leading Strand Synthesis | 14 | 3.30e-02 | 5.80e-02 | 0.5820 | -0.364000 | -0.451000 | 0.058500 | 1.84e-02 | 3.51e-03 | 7.05e-01 |
| Polymerase switching | 14 | 3.30e-02 | 5.80e-02 | 0.5820 | -0.364000 | -0.451000 | 0.058500 | 1.84e-02 | 3.51e-03 | 7.05e-01 |
| SLBP independent Processing of Histone Pre-mRNAs | 10 | 4.92e-03 | 1.15e-02 | 0.5790 | -0.153000 | -0.517000 | -0.212000 | 4.03e-01 | 4.64e-03 | 2.46e-01 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | 15 | 3.95e-03 | 9.66e-03 | 0.5790 | 0.281000 | 0.503000 | -0.060400 | 5.99e-02 | 7.48e-04 | 6.85e-01 |
| The NLRP3 inflammasome | 15 | 1.22e-02 | 2.50e-02 | 0.5760 | 0.457000 | 0.273000 | -0.221000 | 2.18e-03 | 6.76e-02 | 1.39e-01 |
| Homologous DNA Pairing and Strand Exchange | 42 | 2.71e-06 | 1.77e-05 | 0.5760 | -0.354000 | -0.285000 | 0.355000 | 7.31e-05 | 1.42e-03 | 6.98e-05 |
| LDL clearance | 17 | 1.10e-02 | 2.28e-02 | 0.5700 | 0.345000 | 0.307000 | -0.334000 | 1.37e-02 | 2.86e-02 | 1.72e-02 |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | 38 | 4.31e-05 | 1.93e-04 | 0.5690 | 0.432000 | 0.324000 | -0.179000 | 4.09e-06 | 5.43e-04 | 5.59e-02 |
| Signaling by RAS mutants | 38 | 4.31e-05 | 1.93e-04 | 0.5690 | 0.432000 | 0.324000 | -0.179000 | 4.09e-06 | 5.43e-04 | 5.59e-02 |
| Signaling by moderate kinase activity BRAF mutants | 38 | 4.31e-05 | 1.93e-04 | 0.5690 | 0.432000 | 0.324000 | -0.179000 | 4.09e-06 | 5.43e-04 | 5.59e-02 |
| Signaling downstream of RAS mutants | 38 | 4.31e-05 | 1.93e-04 | 0.5690 | 0.432000 | 0.324000 | -0.179000 | 4.09e-06 | 5.43e-04 | 5.59e-02 |
| Presynaptic phase of homologous DNA pairing and strand exchange | 39 | 6.91e-06 | 4.03e-05 | 0.5680 | -0.329000 | -0.277000 | 0.372000 | 3.83e-04 | 2.74e-03 | 5.92e-05 |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 15 | 1.30e-02 | 2.64e-02 | 0.5680 | 0.454000 | 0.266000 | -0.214000 | 2.34e-03 | 7.48e-02 | 1.50e-01 |
| Gastrin-CREB signalling pathway via PKC and MAPK | 14 | 3.83e-02 | 6.59e-02 | 0.5680 | 0.408000 | 0.317000 | -0.234000 | 8.16e-03 | 3.97e-02 | 1.30e-01 |
| G-protein beta:gamma signalling | 29 | 1.06e-03 | 3.12e-03 | 0.5630 | 0.375000 | 0.386000 | -0.163000 | 4.69e-04 | 3.15e-04 | 1.29e-01 |
| Butyrophilin (BTN) family interactions | 10 | 6.59e-02 | 1.06e-01 | 0.5620 | -0.423000 | -0.237000 | 0.285000 | 2.04e-02 | 1.95e-01 | 1.19e-01 |
| Plasma lipoprotein clearance | 28 | 1.21e-04 | 4.80e-04 | 0.5620 | 0.278000 | 0.229000 | -0.432000 | 1.09e-02 | 3.59e-02 | 7.69e-05 |
| Translation | 295 | 5.55e-85 | 2.52e-82 | 0.5620 | -0.055800 | -0.441000 | -0.344000 | 9.90e-02 | 5.79e-39 | 2.80e-24 |
| Signal amplification | 28 | 8.06e-04 | 2.45e-03 | 0.5600 | 0.440000 | 0.318000 | -0.136000 | 5.62e-05 | 3.54e-03 | 2.13e-01 |
| Glycogen metabolism | 23 | 1.96e-03 | 5.32e-03 | 0.5580 | 0.357000 | 0.261000 | -0.340000 | 3.01e-03 | 3.03e-02 | 4.72e-03 |
| Activation of Matrix Metalloproteinases | 22 | 1.43e-03 | 4.04e-03 | 0.5580 | 0.374000 | 0.215000 | -0.354000 | 2.41e-03 | 8.11e-02 | 4.02e-03 |
| HDR through MMEJ (alt-NHEJ) | 10 | 1.22e-01 | 1.76e-01 | 0.5580 | -0.429000 | -0.321000 | 0.153000 | 1.88e-02 | 7.84e-02 | 4.02e-01 |
| ERK/MAPK targets | 22 | 3.04e-03 | 7.71e-03 | 0.5540 | 0.407000 | 0.267000 | -0.265000 | 9.43e-04 | 3.04e-02 | 3.14e-02 |
| Growth hormone receptor signaling | 20 | 1.26e-02 | 2.58e-02 | 0.5540 | 0.421000 | 0.360000 | -0.019500 | 1.13e-03 | 5.30e-03 | 8.80e-01 |
| Interleukin-1 signaling | 97 | 2.47e-14 | 4.94e-13 | 0.5520 | 0.431000 | 0.247000 | -0.242000 | 2.20e-13 | 2.71e-05 | 3.70e-05 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 88 | 2.95e-12 | 5.20e-11 | 0.5520 | 0.415000 | 0.257000 | -0.257000 | 1.73e-11 | 2.98e-05 | 3.08e-05 |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | 23 | 8.52e-04 | 2.57e-03 | 0.5510 | 0.264000 | 0.223000 | -0.429000 | 2.86e-02 | 6.41e-02 | 3.63e-04 |
| Cleavage of the damaged purine | 24 | 5.06e-04 | 1.65e-03 | 0.5500 | 0.352000 | 0.173000 | -0.385000 | 2.80e-03 | 1.42e-01 | 1.10e-03 |
| Depurination | 24 | 5.06e-04 | 1.65e-03 | 0.5500 | 0.352000 | 0.173000 | -0.385000 | 2.80e-03 | 1.42e-01 | 1.10e-03 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 24 | 5.06e-04 | 1.65e-03 | 0.5500 | 0.352000 | 0.173000 | -0.385000 | 2.80e-03 | 1.42e-01 | 1.10e-03 |
| Translesion synthesis by REV1 | 16 | 1.67e-02 | 3.26e-02 | 0.5500 | -0.294000 | -0.438000 | -0.155000 | 4.15e-02 | 2.43e-03 | 2.84e-01 |
| COPI-mediated anterograde transport | 78 | 1.17e-08 | 1.31e-07 | 0.5490 | 0.392000 | 0.370000 | -0.107000 | 2.10e-09 | 1.64e-08 | 1.04e-01 |
| Beta-catenin phosphorylation cascade | 17 | 3.01e-02 | 5.37e-02 | 0.5460 | 0.365000 | 0.369000 | -0.170000 | 9.25e-03 | 8.42e-03 | 2.25e-01 |
| SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 11 | 1.19e-03 | 3.45e-03 | 0.5450 | -0.082600 | -0.499000 | -0.205000 | 6.35e-01 | 4.19e-03 | 2.39e-01 |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | 16 | 8.16e-03 | 1.78e-02 | 0.5450 | 0.366000 | 0.173000 | -0.365000 | 1.12e-02 | 2.30e-01 | 1.15e-02 |
| ADP signalling through P2Y purinoceptor 1 | 21 | 1.13e-02 | 2.33e-02 | 0.5450 | 0.406000 | 0.331000 | -0.151000 | 1.29e-03 | 8.72e-03 | 2.30e-01 |
| tRNA processing in the mitochondrion | 30 | 6.74e-06 | 3.95e-05 | 0.5410 | -0.141000 | -0.152000 | -0.500000 | 1.82e-01 | 1.49e-01 | 2.17e-06 |
| Resolution of Abasic Sites (AP sites) | 37 | 1.58e-04 | 6.05e-04 | 0.5400 | -0.348000 | -0.385000 | -0.151000 | 2.50e-04 | 5.09e-05 | 1.13e-01 |
| TBC/RABGAPs | 45 | 2.38e-06 | 1.57e-05 | 0.5400 | 0.289000 | 0.328000 | -0.316000 | 7.88e-04 | 1.38e-04 | 2.48e-04 |
| ERBB2 Regulates Cell Motility | 10 | 3.82e-02 | 6.59e-02 | 0.5380 | 0.315000 | 0.081800 | -0.429000 | 8.47e-02 | 6.54e-01 | 1.88e-02 |
| MyD88 dependent cascade initiated on endosome | 89 | 1.65e-11 | 2.74e-10 | 0.5370 | 0.403000 | 0.258000 | -0.244000 | 5.11e-11 | 2.53e-05 | 6.76e-05 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | 89 | 1.65e-11 | 2.74e-10 | 0.5370 | 0.403000 | 0.258000 | -0.244000 | 5.11e-11 | 2.53e-05 | 6.76e-05 |
| MyD88 cascade initiated on plasma membrane | 82 | 3.50e-11 | 5.29e-10 | 0.5360 | 0.395000 | 0.233000 | -0.277000 | 6.13e-10 | 2.69e-04 | 1.44e-05 |
| Toll Like Receptor 10 (TLR10) Cascade | 82 | 3.50e-11 | 5.29e-10 | 0.5360 | 0.395000 | 0.233000 | -0.277000 | 6.13e-10 | 2.69e-04 | 1.44e-05 |
| Toll Like Receptor 5 (TLR5) Cascade | 82 | 3.50e-11 | 5.29e-10 | 0.5360 | 0.395000 | 0.233000 | -0.277000 | 6.13e-10 | 2.69e-04 | 1.44e-05 |
| ATF6 (ATF6-alpha) activates chaperone genes | 10 | 8.58e-02 | 1.30e-01 | 0.5350 | 0.446000 | 0.294000 | 0.037500 | 1.46e-02 | 1.07e-01 | 8.37e-01 |
| Interleukin-6 signaling | 10 | 1.76e-01 | 2.37e-01 | 0.5350 | 0.401000 | 0.350000 | -0.052600 | 2.81e-02 | 5.50e-02 | 7.73e-01 |
| Gluconeogenesis | 28 | 2.08e-04 | 7.71e-04 | 0.5350 | 0.242000 | 0.227000 | -0.420000 | 2.68e-02 | 3.76e-02 | 1.20e-04 |
| Thrombin signalling through proteinase activated receptors (PARs) | 27 | 2.48e-03 | 6.52e-03 | 0.5340 | 0.354000 | 0.314000 | -0.248000 | 1.47e-03 | 4.76e-03 | 2.58e-02 |
| trans-Golgi Network Vesicle Budding | 69 | 1.35e-07 | 1.27e-06 | 0.5330 | 0.371000 | 0.331000 | -0.193000 | 1.01e-07 | 1.99e-06 | 5.46e-03 |
| Transcriptional regulation of granulopoiesis | 46 | 6.40e-06 | 3.80e-05 | 0.5330 | 0.419000 | 0.272000 | -0.185000 | 8.80e-07 | 1.39e-03 | 2.98e-02 |
| Negative regulation of FGFR3 signaling | 20 | 5.38e-03 | 1.24e-02 | 0.5310 | 0.338000 | 0.204000 | -0.356000 | 8.93e-03 | 1.15e-01 | 5.88e-03 |
| Toll Like Receptor 4 (TLR4) Cascade | 121 | 2.06e-14 | 4.18e-13 | 0.5310 | 0.398000 | 0.277000 | -0.216000 | 3.68e-14 | 1.44e-07 | 4.18e-05 |
| COPII-mediated vesicle transport | 65 | 8.56e-07 | 6.58e-06 | 0.5300 | 0.389000 | 0.356000 | -0.053800 | 5.77e-08 | 6.84e-07 | 4.53e-01 |
| Platelet activation, signaling and aggregation | 219 | 6.37e-25 | 1.84e-23 | 0.5300 | 0.360000 | 0.293000 | -0.256000 | 3.93e-20 | 7.72e-14 | 6.53e-11 |
| Inhibition of DNA recombination at telomere | 35 | 8.12e-06 | 4.66e-05 | 0.5290 | 0.343000 | 0.131000 | -0.382000 | 4.49e-04 | 1.81e-01 | 9.26e-05 |
| Regulation of signaling by CBL | 18 | 5.06e-03 | 1.18e-02 | 0.5280 | 0.261000 | 0.408000 | -0.211000 | 5.48e-02 | 2.74e-03 | 1.21e-01 |
| Activated NOTCH1 Transmits Signal to the Nucleus | 27 | 6.66e-04 | 2.09e-03 | 0.5270 | 0.268000 | 0.263000 | -0.370000 | 1.61e-02 | 1.78e-02 | 8.86e-04 |
| Signalling to ERKs | 31 | 1.86e-03 | 5.11e-03 | 0.5270 | 0.397000 | 0.339000 | -0.071700 | 1.30e-04 | 1.10e-03 | 4.90e-01 |
| Cristae formation | 31 | 7.48e-08 | 7.43e-07 | 0.5250 | 0.263000 | -0.091500 | -0.445000 | 1.11e-02 | 3.78e-01 | 1.78e-05 |
| Cytosolic iron-sulfur cluster assembly | 13 | 1.70e-02 | 3.30e-02 | 0.5230 | -0.187000 | -0.203000 | -0.445000 | 2.43e-01 | 2.05e-01 | 5.50e-03 |
| PKA activation | 15 | 2.26e-02 | 4.24e-02 | 0.5230 | 0.265000 | 0.203000 | -0.403000 | 7.57e-02 | 1.73e-01 | 6.91e-03 |
| Rev-mediated nuclear export of HIV RNA | 35 | 5.94e-04 | 1.91e-03 | 0.5230 | -0.334000 | -0.381000 | 0.130000 | 6.31e-04 | 9.63e-05 | 1.82e-01 |
| RHO GTPases activate KTN1 | 11 | 1.46e-01 | 2.02e-01 | 0.5220 | 0.391000 | 0.311000 | -0.149000 | 2.47e-02 | 7.38e-02 | 3.93e-01 |
| Biotin transport and metabolism | 11 | 7.53e-02 | 1.18e-01 | 0.5210 | -0.439000 | -0.281000 | -0.003510 | 1.17e-02 | 1.07e-01 | 9.84e-01 |
| DARPP-32 events | 22 | 9.44e-03 | 2.03e-02 | 0.5210 | 0.401000 | 0.286000 | -0.168000 | 1.11e-03 | 2.01e-02 | 1.74e-01 |
| RORA activates gene expression | 18 | 2.25e-02 | 4.23e-02 | 0.5210 | 0.312000 | 0.401000 | -0.114000 | 2.21e-02 | 3.21e-03 | 4.02e-01 |
| Polymerase switching on the C-strand of the telomere | 26 | 3.40e-03 | 8.44e-03 | 0.5200 | -0.305000 | -0.406000 | -0.113000 | 7.06e-03 | 3.37e-04 | 3.20e-01 |
| The role of Nef in HIV-1 replication and disease pathogenesis | 28 | 2.87e-04 | 1.01e-03 | 0.5180 | 0.229000 | 0.143000 | -0.442000 | 3.63e-02 | 1.91e-01 | 5.11e-05 |
| NEP/NS2 Interacts with the Cellular Export Machinery | 32 | 1.03e-03 | 3.04e-03 | 0.5170 | -0.321000 | -0.352000 | 0.201000 | 1.66e-03 | 5.69e-04 | 4.88e-02 |
| Metabolism of Angiotensinogen to Angiotensins | 11 | 4.48e-02 | 7.53e-02 | 0.5170 | 0.392000 | 0.160000 | -0.297000 | 2.44e-02 | 3.58e-01 | 8.85e-02 |
| Negative regulation of FGFR4 signaling | 21 | 4.11e-03 | 9.96e-03 | 0.5170 | 0.313000 | 0.172000 | -0.374000 | 1.29e-02 | 1.74e-01 | 3.02e-03 |
| Clathrin-mediated endocytosis | 127 | 5.96e-13 | 1.10e-11 | 0.5160 | 0.357000 | 0.321000 | -0.190000 | 3.49e-12 | 4.24e-10 | 2.23e-04 |
| Interactions of Rev with host cellular proteins | 37 | 4.18e-04 | 1.41e-03 | 0.5160 | -0.326000 | -0.375000 | 0.140000 | 5.92e-04 | 8.02e-05 | 1.41e-01 |
| Signaling by ROBO receptors | 199 | 2.80e-39 | 1.23e-37 | 0.5160 | -0.010200 | -0.276000 | -0.435000 | 8.04e-01 | 1.82e-11 | 2.88e-26 |
| Pausing and recovery of Tat-mediated HIV elongation | 30 | 5.55e-05 | 2.44e-04 | 0.5150 | 0.167000 | 0.034000 | -0.486000 | 1.14e-01 | 7.48e-01 | 4.08e-06 |
| Tat-mediated HIV elongation arrest and recovery | 30 | 5.55e-05 | 2.44e-04 | 0.5150 | 0.167000 | 0.034000 | -0.486000 | 1.14e-01 | 7.48e-01 | 4.08e-06 |
| Adenylate cyclase inhibitory pathway | 11 | 4.16e-02 | 7.08e-02 | 0.5150 | 0.216000 | 0.334000 | -0.326000 | 2.14e-01 | 5.49e-02 | 6.09e-02 |
| ER to Golgi Anterograde Transport | 129 | 1.99e-12 | 3.55e-11 | 0.5150 | 0.371000 | 0.348000 | -0.077200 | 3.31e-13 | 8.05e-12 | 1.30e-01 |
| HDACs deacetylate histones | 47 | 9.43e-06 | 5.32e-05 | 0.5150 | 0.358000 | 0.235000 | -0.286000 | 2.16e-05 | 5.33e-03 | 7.03e-04 |
| Antigen processing-Cross presentation | 97 | 4.75e-11 | 6.87e-10 | 0.5140 | 0.401000 | 0.271000 | -0.172000 | 8.19e-12 | 3.89e-06 | 3.44e-03 |
| Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters | 21 | 1.80e-03 | 4.99e-03 | 0.5120 | 0.192000 | 0.065800 | -0.470000 | 1.28e-01 | 6.01e-01 | 1.89e-04 |
| VxPx cargo-targeting to cilium | 19 | 2.95e-02 | 5.29e-02 | 0.5120 | 0.325000 | 0.393000 | 0.044500 | 1.43e-02 | 2.99e-03 | 7.37e-01 |
| Post-translational protein phosphorylation | 69 | 5.64e-07 | 4.56e-06 | 0.5120 | 0.344000 | 0.339000 | -0.169000 | 7.45e-07 | 1.15e-06 | 1.51e-02 |
| Energy dependent regulation of mTOR by LKB1-AMPK | 27 | 6.45e-03 | 1.45e-02 | 0.5120 | 0.385000 | 0.326000 | -0.082400 | 5.31e-04 | 3.32e-03 | 4.59e-01 |
| Pre-NOTCH Expression and Processing | 65 | 1.19e-06 | 8.76e-06 | 0.5110 | 0.348000 | 0.321000 | -0.193000 | 1.26e-06 | 7.52e-06 | 7.05e-03 |
| p75NTR signals via NF-kB | 15 | 1.40e-02 | 2.82e-02 | 0.5110 | 0.291000 | 0.100000 | -0.407000 | 5.07e-02 | 5.01e-01 | 6.31e-03 |
| BBSome-mediated cargo-targeting to cilium | 22 | 1.63e-04 | 6.21e-04 | 0.5100 | -0.195000 | -0.470000 | 0.026800 | 1.14e-01 | 1.34e-04 | 8.28e-01 |
| Diseases of DNA repair | 10 | 2.18e-01 | 2.79e-01 | 0.5090 | -0.366000 | -0.354000 | -0.012100 | 4.52e-02 | 5.26e-02 | 9.47e-01 |
| Toll Like Receptor 9 (TLR9) Cascade | 93 | 5.57e-11 | 7.90e-10 | 0.5080 | 0.389000 | 0.242000 | -0.221000 | 9.24e-11 | 5.43e-05 | 2.28e-04 |
| rRNA processing in the mitochondrion | 27 | 3.55e-04 | 1.23e-03 | 0.5080 | -0.156000 | -0.274000 | -0.398000 | 1.60e-01 | 1.37e-02 | 3.39e-04 |
| Extension of Telomeres | 51 | 2.03e-05 | 1.00e-04 | 0.5070 | -0.311000 | -0.393000 | -0.078500 | 1.21e-04 | 1.19e-06 | 3.32e-01 |
| ATF6 (ATF6-alpha) activates chaperones | 12 | 8.51e-02 | 1.30e-01 | 0.5060 | 0.416000 | 0.287000 | 0.016400 | 1.26e-02 | 8.49e-02 | 9.22e-01 |
| Metabolism of non-coding RNA | 53 | 1.92e-07 | 1.73e-06 | 0.5050 | -0.255000 | -0.425000 | 0.098000 | 1.31e-03 | 8.72e-08 | 2.17e-01 |
| snRNP Assembly | 53 | 1.92e-07 | 1.73e-06 | 0.5050 | -0.255000 | -0.425000 | 0.098000 | 1.31e-03 | 8.72e-08 | 2.17e-01 |
| Cell-extracellular matrix interactions | 14 | 3.98e-02 | 6.82e-02 | 0.5050 | 0.366000 | 0.195000 | -0.287000 | 1.78e-02 | 2.05e-01 | 6.27e-02 |
| EPH-ephrin mediated repulsion of cells | 39 | 2.86e-05 | 1.35e-04 | 0.5040 | 0.238000 | 0.252000 | -0.366000 | 1.00e-02 | 6.53e-03 | 7.80e-05 |
| Vpr-mediated nuclear import of PICs | 34 | 9.37e-04 | 2.79e-03 | 0.5030 | -0.309000 | -0.369000 | 0.147000 | 1.85e-03 | 1.96e-04 | 1.38e-01 |
| Cellular response to hypoxia | 71 | 2.11e-08 | 2.26e-07 | 0.5030 | 0.388000 | 0.236000 | -0.215000 | 1.49e-08 | 5.75e-04 | 1.74e-03 |
| Glycosphingolipid metabolism | 36 | 1.02e-04 | 4.17e-04 | 0.5020 | 0.253000 | 0.296000 | -0.317000 | 8.55e-03 | 2.13e-03 | 1.01e-03 |
| Pre-NOTCH Transcription and Translation | 49 | 7.44e-05 | 3.16e-04 | 0.5020 | 0.352000 | 0.315000 | -0.171000 | 2.05e-05 | 1.38e-04 | 3.83e-02 |
| Disassembly of the destruction complex and recruitment of AXIN to the membrane | 29 | 1.55e-03 | 4.35e-03 | 0.5010 | 0.301000 | 0.235000 | -0.325000 | 4.99e-03 | 2.85e-02 | 2.47e-03 |
| Toll-like Receptor Cascades | 143 | 3.56e-15 | 7.68e-14 | 0.5010 | 0.383000 | 0.263000 | -0.187000 | 2.72e-15 | 5.32e-08 | 1.16e-04 |
| Iron uptake and transport | 52 | 8.97e-07 | 6.78e-06 | 0.4960 | 0.376000 | 0.191000 | -0.261000 | 2.76e-06 | 1.71e-02 | 1.12e-03 |
| Signaling by BRAF and RAF fusions | 57 | 5.17e-06 | 3.15e-05 | 0.4950 | 0.390000 | 0.273000 | -0.137000 | 3.46e-07 | 3.62e-04 | 7.40e-02 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | 124 | 2.11e-24 | 5.99e-23 | 0.4950 | 0.263000 | -0.033900 | -0.418000 | 4.20e-07 | 5.15e-01 | 8.74e-16 |
| Golgi Associated Vesicle Biogenesis | 55 | 2.44e-05 | 1.18e-04 | 0.4950 | 0.367000 | 0.297000 | -0.148000 | 2.49e-06 | 1.36e-04 | 5.79e-02 |
| Complex I biogenesis | 55 | 3.16e-10 | 4.30e-09 | 0.4950 | 0.251000 | -0.022000 | -0.426000 | 1.30e-03 | 7.78e-01 | 4.58e-08 |
| Mitochondrial tRNA aminoacylation | 21 | 2.37e-02 | 4.41e-02 | 0.4950 | -0.311000 | -0.371000 | 0.101000 | 1.36e-02 | 3.21e-03 | 4.23e-01 |
| Cargo recognition for clathrin-mediated endocytosis | 90 | 9.47e-09 | 1.07e-07 | 0.4940 | 0.333000 | 0.296000 | -0.215000 | 4.64e-08 | 1.24e-06 | 4.33e-04 |
| Signaling by NTRK1 (TRKA) | 100 | 5.47e-10 | 7.29e-09 | 0.4940 | 0.367000 | 0.272000 | -0.189000 | 2.21e-10 | 2.63e-06 | 1.09e-03 |
| Innate Immune System | 966 | 2.31e-93 | 1.57e-90 | 0.4940 | 0.367000 | 0.270000 | -0.191000 | 8.55e-84 | 4.65e-46 | 8.58e-24 |
| RAB geranylgeranylation | 60 | 1.25e-05 | 6.70e-05 | 0.4940 | 0.366000 | 0.311000 | -0.114000 | 9.21e-07 | 3.04e-05 | 1.27e-01 |
| Signaling by NTRKs | 115 | 2.53e-11 | 4.15e-10 | 0.4930 | 0.363000 | 0.274000 | -0.191000 | 1.67e-11 | 4.00e-07 | 3.99e-04 |
| Translesion synthesis by POLI | 17 | 2.90e-02 | 5.22e-02 | 0.4930 | -0.261000 | -0.407000 | -0.098600 | 6.24e-02 | 3.70e-03 | 4.82e-01 |
| Glucagon signaling in metabolic regulation | 27 | 5.92e-03 | 1.34e-02 | 0.4930 | 0.333000 | 0.271000 | -0.242000 | 2.73e-03 | 1.49e-02 | 2.93e-02 |
| Activation of the AP-1 family of transcription factors | 10 | 1.12e-01 | 1.63e-01 | 0.4910 | 0.390000 | 0.196000 | -0.226000 | 3.26e-02 | 2.84e-01 | 2.17e-01 |
| Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 14 | 1.01e-01 | 1.51e-01 | 0.4910 | -0.307000 | -0.381000 | 0.046000 | 4.70e-02 | 1.36e-02 | 7.66e-01 |
| Interactions of Vpr with host cellular proteins | 37 | 3.86e-04 | 1.32e-03 | 0.4910 | -0.285000 | -0.389000 | 0.093300 | 2.71e-03 | 4.25e-05 | 3.26e-01 |
| Gap-filling DNA repair synthesis and ligation in GG-NER | 25 | 2.66e-03 | 6.93e-03 | 0.4900 | -0.223000 | -0.376000 | -0.222000 | 5.40e-02 | 1.13e-03 | 5.47e-02 |
| Calnexin/calreticulin cycle | 26 | 6.20e-03 | 1.40e-02 | 0.4890 | 0.365000 | 0.250000 | -0.210000 | 1.29e-03 | 2.73e-02 | 6.41e-02 |
| RAF activation | 32 | 3.22e-03 | 8.09e-03 | 0.4890 | 0.365000 | 0.323000 | 0.040100 | 3.52e-04 | 1.59e-03 | 6.95e-01 |
| Folding of actin by CCT/TriC | 10 | 7.67e-04 | 2.35e-03 | 0.4880 | 0.135000 | -0.355000 | -0.306000 | 4.61e-01 | 5.18e-02 | 9.35e-02 |
| Nuclear import of Rev protein | 34 | 1.81e-03 | 4.99e-03 | 0.4870 | -0.306000 | -0.348000 | 0.151000 | 2.03e-03 | 4.39e-04 | 1.28e-01 |
| Formation of Fibrin Clot (Clotting Cascade) | 26 | 2.95e-03 | 7.55e-03 | 0.4870 | 0.287000 | 0.183000 | -0.349000 | 1.14e-02 | 1.06e-01 | 2.09e-03 |
| Signaling by EGFR | 46 | 3.34e-05 | 1.55e-04 | 0.4870 | 0.334000 | 0.211000 | -0.284000 | 8.69e-05 | 1.33e-02 | 8.45e-04 |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | 27 | 2.99e-03 | 7.62e-03 | 0.4870 | 0.336000 | 0.205000 | -0.286000 | 2.52e-03 | 6.55e-02 | 1.00e-02 |
| tRNA modification in the nucleus and cytosol | 43 | 8.31e-05 | 3.49e-04 | 0.4860 | -0.274000 | -0.397000 | 0.052000 | 1.85e-03 | 6.47e-06 | 5.55e-01 |
| NS1 Mediated Effects on Host Pathways | 40 | 4.30e-04 | 1.44e-03 | 0.4840 | -0.305000 | -0.286000 | 0.245000 | 8.43e-04 | 1.77e-03 | 7.30e-03 |
| Heparan sulfate/heparin (HS-GAG) metabolism | 37 | 1.13e-05 | 6.12e-05 | 0.4840 | 0.116000 | 0.120000 | -0.455000 | 2.23e-01 | 2.07e-01 | 1.70e-06 |
| MET activates RAS signaling | 10 | 1.85e-01 | 2.45e-01 | 0.4840 | 0.355000 | 0.300000 | 0.135000 | 5.19e-02 | 1.01e-01 | 4.59e-01 |
| mTORC1-mediated signalling | 23 | 4.55e-03 | 1.08e-02 | 0.4830 | 0.372000 | 0.189000 | -0.243000 | 2.01e-03 | 1.17e-01 | 4.39e-02 |
| Senescence-Associated Secretory Phenotype (SASP) | 66 | 1.24e-07 | 1.18e-06 | 0.4820 | 0.299000 | 0.177000 | -0.334000 | 2.67e-05 | 1.28e-02 | 2.60e-06 |
| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | 31 | 4.12e-03 | 9.96e-03 | 0.4810 | -0.309000 | -0.316000 | 0.191000 | 2.93e-03 | 2.29e-03 | 6.60e-02 |
| Regulation of Glucokinase by Glucokinase Regulatory Protein | 31 | 4.12e-03 | 9.96e-03 | 0.4810 | -0.309000 | -0.316000 | 0.191000 | 2.93e-03 | 2.29e-03 | 6.60e-02 |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | 36 | 2.03e-04 | 7.56e-04 | 0.4810 | 0.404000 | 0.229000 | -0.125000 | 2.73e-05 | 1.72e-02 | 1.94e-01 |
| Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | 26 | 1.61e-03 | 4.53e-03 | 0.4800 | -0.243000 | -0.114000 | 0.398000 | 3.17e-02 | 3.14e-01 | 4.42e-04 |
| Respiratory electron transport | 101 | 6.60e-19 | 1.63e-17 | 0.4800 | 0.265000 | -0.027700 | -0.399000 | 4.04e-06 | 6.30e-01 | 4.30e-12 |
| Plasma lipoprotein assembly | 10 | 1.37e-01 | 1.93e-01 | 0.4790 | 0.234000 | 0.289000 | -0.302000 | 1.99e-01 | 1.14e-01 | 9.77e-02 |
| HuR (ELAVL1) binds and stabilizes mRNA | 10 | 1.38e-01 | 1.94e-01 | 0.4790 | 0.408000 | 0.251000 | -0.003050 | 2.53e-02 | 1.70e-01 | 9.87e-01 |
| tRNA processing in the nucleus | 59 | 9.82e-06 | 5.45e-05 | 0.4780 | -0.291000 | -0.363000 | 0.111000 | 1.12e-04 | 1.37e-06 | 1.42e-01 |
| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | 53 | 6.71e-07 | 5.22e-06 | 0.4780 | 0.387000 | 0.183000 | -0.212000 | 1.08e-06 | 2.11e-02 | 7.54e-03 |
| G beta:gamma signalling through PI3Kgamma | 22 | 2.00e-02 | 3.83e-02 | 0.4770 | 0.286000 | 0.331000 | -0.189000 | 2.01e-02 | 7.11e-03 | 1.26e-01 |
| Thromboxane signalling through TP receptor | 20 | 2.64e-02 | 4.83e-02 | 0.4770 | 0.374000 | 0.247000 | -0.163000 | 3.82e-03 | 5.56e-02 | 2.06e-01 |
| MAP kinase activation | 63 | 6.03e-07 | 4.85e-06 | 0.4770 | 0.366000 | 0.213000 | -0.218000 | 4.93e-07 | 3.41e-03 | 2.74e-03 |
| Apoptosis induced DNA fragmentation | 10 | 2.33e-01 | 2.95e-01 | 0.4760 | 0.377000 | 0.290000 | -0.026500 | 3.91e-02 | 1.12e-01 | 8.85e-01 |
| Regulation of localization of FOXO transcription factors | 11 | 1.23e-01 | 1.77e-01 | 0.4760 | 0.241000 | 0.198000 | -0.360000 | 1.67e-01 | 2.55e-01 | 3.87e-02 |
| Presynaptic function of Kainate receptors | 18 | 5.44e-02 | 8.98e-02 | 0.4760 | 0.320000 | 0.272000 | -0.223000 | 1.87e-02 | 4.54e-02 | 1.01e-01 |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 22 | 3.08e-03 | 7.79e-03 | 0.4750 | 0.302000 | 0.100000 | -0.353000 | 1.42e-02 | 4.16e-01 | 4.18e-03 |
| A tetrasaccharide linker sequence is required for GAG synthesis | 17 | 1.23e-02 | 2.51e-02 | 0.4740 | -0.158000 | -0.182000 | -0.408000 | 2.61e-01 | 1.95e-01 | 3.56e-03 |
| Interleukin-1 family signaling | 124 | 1.80e-12 | 3.26e-11 | 0.4740 | 0.360000 | 0.230000 | -0.205000 | 4.29e-12 | 1.01e-05 | 7.97e-05 |
| ADP signalling through P2Y purinoceptor 12 | 18 | 5.40e-02 | 8.92e-02 | 0.4740 | 0.376000 | 0.282000 | -0.055100 | 5.73e-03 | 3.80e-02 | 6.86e-01 |
| Signaling by MET | 61 | 1.93e-05 | 9.65e-05 | 0.4730 | 0.366000 | 0.294000 | -0.064400 | 7.71e-07 | 7.27e-05 | 3.84e-01 |
| G beta:gamma signalling through PLC beta | 17 | 6.70e-02 | 1.07e-01 | 0.4730 | 0.340000 | 0.261000 | -0.201000 | 1.53e-02 | 6.23e-02 | 1.51e-01 |
| Olfactory Signaling Pathway | 57 | 4.90e-08 | 5.02e-07 | 0.4730 | 0.086100 | 0.155000 | 0.438000 | 2.61e-01 | 4.29e-02 | 1.04e-08 |
| Syndecan interactions | 19 | 5.99e-04 | 1.92e-03 | 0.4720 | 0.352000 | 0.030300 | -0.314000 | 7.93e-03 | 8.19e-01 | 1.79e-02 |
| Alpha-protein kinase 1 signaling pathway | 11 | 2.19e-02 | 4.12e-02 | 0.4720 | 0.436000 | 0.135000 | -0.118000 | 1.22e-02 | 4.38e-01 | 4.97e-01 |
| Regulation of ornithine decarboxylase (ODC) | 49 | 1.84e-06 | 1.27e-05 | 0.4720 | 0.386000 | 0.175000 | -0.207000 | 2.90e-06 | 3.46e-02 | 1.23e-02 |
| Postmitotic nuclear pore complex (NPC) reformation | 27 | 4.64e-03 | 1.10e-02 | 0.4710 | -0.263000 | -0.373000 | 0.116000 | 1.81e-02 | 8.00e-04 | 2.95e-01 |
| Cross-presentation of soluble exogenous antigens (endosomes) | 47 | 5.93e-06 | 3.55e-05 | 0.4710 | 0.398000 | 0.199000 | -0.154000 | 2.35e-06 | 1.83e-02 | 6.83e-02 |
| HDR through Single Strand Annealing (SSA) | 37 | 6.78e-04 | 2.12e-03 | 0.4710 | -0.278000 | -0.234000 | 0.299000 | 3.44e-03 | 1.36e-02 | 1.66e-03 |
| HDMs demethylate histones | 22 | 8.28e-03 | 1.80e-02 | 0.4700 | 0.244000 | 0.371000 | -0.156000 | 4.78e-02 | 2.60e-03 | 2.05e-01 |
| Transport of Ribonucleoproteins into the Host Nucleus | 32 | 3.38e-03 | 8.39e-03 | 0.4700 | -0.288000 | -0.305000 | 0.212000 | 4.84e-03 | 2.79e-03 | 3.78e-02 |
| Scavenging by Class A Receptors | 11 | 1.96e-01 | 2.57e-01 | 0.4700 | 0.370000 | 0.289000 | 0.018000 | 3.36e-02 | 9.72e-02 | 9.18e-01 |
| Translation of Replicase and Assembly of the Replication Transcription Complex | 12 | 1.29e-01 | 1.84e-01 | 0.4690 | 0.388000 | 0.248000 | -0.088800 | 1.99e-02 | 1.37e-01 | 5.94e-01 |
| tRNA Aminoacylation | 42 | 5.63e-05 | 2.47e-04 | 0.4690 | -0.243000 | -0.373000 | 0.147000 | 6.51e-03 | 2.90e-05 | 9.87e-02 |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | 11 | 8.79e-02 | 1.33e-01 | 0.4680 | -0.274000 | -0.095500 | 0.367000 | 1.15e-01 | 5.84e-01 | 3.50e-02 |
| Interleukin-3, Interleukin-5 and GM-CSF signaling | 40 | 8.47e-05 | 3.53e-04 | 0.4680 | 0.239000 | 0.365000 | -0.169000 | 8.83e-03 | 6.50e-05 | 6.43e-02 |
| ER-Phagosome pathway | 82 | 2.88e-08 | 3.03e-07 | 0.4680 | 0.366000 | 0.227000 | -0.182000 | 1.02e-08 | 3.73e-04 | 4.36e-03 |
| G beta:gamma signalling through CDC42 | 17 | 7.96e-02 | 1.23e-01 | 0.4670 | 0.359000 | 0.299000 | 0.010700 | 1.05e-02 | 3.26e-02 | 9.39e-01 |
| PINK1-PRKN Mediated Mitophagy | 21 | 2.31e-06 | 1.54e-05 | 0.4670 | 0.187000 | -0.250000 | -0.347000 | 1.39e-01 | 4.70e-02 | 5.89e-03 |
| Synthesis of PIPs at the late endosome membrane | 11 | 7.22e-02 | 1.14e-01 | 0.4670 | 0.205000 | 0.185000 | 0.376000 | 2.39e-01 | 2.89e-01 | 3.07e-02 |
| Regulation of activated PAK-2p34 by proteasome mediated degradation | 48 | 2.27e-06 | 1.52e-05 | 0.4660 | 0.377000 | 0.161000 | -0.221000 | 6.02e-06 | 5.38e-02 | 7.98e-03 |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | 16 | 4.39e-02 | 7.39e-02 | 0.4660 | 0.364000 | 0.198000 | -0.212000 | 1.16e-02 | 1.71e-01 | 1.42e-01 |
| Mitochondrial translation elongation | 91 | 2.10e-20 | 5.49e-19 | 0.4650 | -0.011100 | -0.366000 | -0.287000 | 8.55e-01 | 1.54e-09 | 2.28e-06 |
| PCP/CE pathway | 86 | 7.75e-09 | 9.00e-08 | 0.4650 | 0.305000 | 0.190000 | -0.295000 | 1.03e-06 | 2.32e-03 | 2.21e-06 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | 53 | 1.49e-07 | 1.38e-06 | 0.4650 | 0.366000 | 0.129000 | -0.255000 | 3.95e-06 | 1.05e-01 | 1.32e-03 |
| Plasma lipoprotein assembly, remodeling, and clearance | 52 | 1.95e-05 | 9.71e-05 | 0.4640 | 0.250000 | 0.256000 | -0.296000 | 1.81e-03 | 1.38e-03 | 2.27e-04 |
| Processive synthesis on the C-strand of the telomere | 19 | 3.60e-02 | 6.28e-02 | 0.4640 | -0.255000 | -0.377000 | -0.092300 | 5.44e-02 | 4.47e-03 | 4.86e-01 |
| Inflammasomes | 20 | 1.13e-02 | 2.33e-02 | 0.4640 | 0.399000 | 0.208000 | -0.112000 | 1.99e-03 | 1.07e-01 | 3.88e-01 |
| RAB GEFs exchange GTP for GDP on RABs | 87 | 5.02e-07 | 4.11e-06 | 0.4630 | 0.316000 | 0.317000 | -0.119000 | 3.51e-07 | 3.28e-07 | 5.50e-02 |
| Defective CFTR causes cystic fibrosis | 59 | 6.53e-07 | 5.13e-06 | 0.4630 | 0.366000 | 0.180000 | -0.219000 | 1.17e-06 | 1.66e-02 | 3.67e-03 |
| Negative regulation of FGFR1 signaling | 24 | 1.65e-02 | 3.23e-02 | 0.4620 | 0.299000 | 0.232000 | -0.265000 | 1.13e-02 | 4.90e-02 | 2.47e-02 |
| Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 30 | 5.87e-05 | 2.56e-04 | 0.4620 | 0.391000 | 0.118000 | -0.216000 | 2.13e-04 | 2.64e-01 | 4.04e-02 |
| Fanconi Anemia Pathway | 36 | 3.46e-03 | 8.56e-03 | 0.4610 | -0.354000 | -0.288000 | 0.066800 | 2.37e-04 | 2.74e-03 | 4.88e-01 |
| Translesion synthesis by POLK | 17 | 4.51e-02 | 7.57e-02 | 0.4610 | -0.240000 | -0.383000 | -0.092300 | 8.61e-02 | 6.30e-03 | 5.10e-01 |
| Regulation of FZD by ubiquitination | 15 | 9.40e-03 | 2.03e-02 | 0.4610 | -0.009250 | -0.264000 | -0.378000 | 9.51e-01 | 7.69e-02 | 1.12e-02 |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 64 | 5.08e-07 | 4.13e-06 | 0.4610 | 0.367000 | 0.198000 | -0.196000 | 3.69e-07 | 6.09e-03 | 6.76e-03 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | 23 | 2.84e-03 | 7.30e-03 | 0.4600 | 0.155000 | 0.008530 | -0.433000 | 1.99e-01 | 9.44e-01 | 3.28e-04 |
| Export of Viral Ribonucleoproteins from Nucleus | 33 | 4.35e-03 | 1.04e-02 | 0.4590 | -0.285000 | -0.317000 | 0.171000 | 4.58e-03 | 1.64e-03 | 8.99e-02 |
| Beta-oxidation of very long chain fatty acids | 10 | 2.54e-01 | 3.17e-01 | 0.4590 | 0.278000 | 0.344000 | -0.122000 | 1.28e-01 | 5.98e-02 | 5.03e-01 |
| Downregulation of ERBB2 signaling | 24 | 9.71e-04 | 2.89e-03 | 0.4580 | 0.216000 | -0.005660 | -0.404000 | 6.66e-02 | 9.62e-01 | 6.19e-04 |
| Amino acids regulate mTORC1 | 50 | 1.63e-04 | 6.21e-04 | 0.4580 | 0.315000 | 0.246000 | -0.225000 | 1.19e-04 | 2.66e-03 | 5.98e-03 |
| Transport of the SLBP independent Mature mRNA | 35 | 2.12e-03 | 5.73e-03 | 0.4580 | -0.270000 | -0.309000 | 0.202000 | 5.64e-03 | 1.54e-03 | 3.91e-02 |
| Hh mutants abrogate ligand secretion | 54 | 1.75e-06 | 1.22e-05 | 0.4570 | 0.367000 | 0.170000 | -0.212000 | 3.12e-06 | 3.08e-02 | 6.97e-03 |
| Aquaporin-mediated transport | 37 | 1.73e-03 | 4.82e-03 | 0.4560 | 0.313000 | 0.234000 | -0.236000 | 9.99e-04 | 1.38e-02 | 1.30e-02 |
| Regulation of TP53 Activity through Association with Co-factors | 11 | 8.63e-02 | 1.31e-01 | 0.4560 | -0.074200 | -0.157000 | -0.421000 | 6.70e-01 | 3.66e-01 | 1.56e-02 |
| N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 35 | 1.37e-03 | 3.92e-03 | 0.4550 | 0.314000 | 0.197000 | -0.264000 | 1.30e-03 | 4.41e-02 | 6.77e-03 |
| Degradation of DVL | 54 | 1.30e-06 | 9.40e-06 | 0.4550 | 0.360000 | 0.157000 | -0.230000 | 4.80e-06 | 4.57e-02 | 3.40e-03 |
| mRNA decay by 3' to 5' exoribonuclease | 16 | 5.78e-02 | 9.45e-02 | 0.4550 | -0.235000 | -0.380000 | -0.087400 | 1.04e-01 | 8.48e-03 | 5.45e-01 |
| Formation of the cornified envelope | 21 | 2.87e-02 | 5.20e-02 | 0.4540 | 0.372000 | 0.244000 | -0.094400 | 3.19e-03 | 5.33e-02 | 4.54e-01 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 79 | 2.28e-06 | 1.52e-05 | 0.4540 | 0.307000 | 0.288000 | -0.169000 | 2.30e-06 | 9.79e-06 | 9.36e-03 |
| Early Phase of HIV Life Cycle | 14 | 3.83e-02 | 6.59e-02 | 0.4540 | -0.150000 | -0.358000 | -0.235000 | 3.31e-01 | 2.04e-02 | 1.28e-01 |
| MTOR signalling | 38 | 1.35e-03 | 3.86e-03 | 0.4530 | 0.354000 | 0.238000 | -0.154000 | 1.60e-04 | 1.12e-02 | 1.01e-01 |
| HS-GAG degradation | 16 | 2.73e-02 | 4.97e-02 | 0.4520 | 0.141000 | 0.032500 | -0.428000 | 3.29e-01 | 8.22e-01 | 3.03e-03 |
| XBP1(S) activates chaperone genes | 47 | 3.25e-04 | 1.13e-03 | 0.4520 | 0.278000 | 0.273000 | -0.228000 | 9.69e-04 | 1.18e-03 | 6.87e-03 |
| Interleukin-17 signaling | 68 | 1.02e-06 | 7.66e-06 | 0.4520 | 0.337000 | 0.197000 | -0.228000 | 1.58e-06 | 5.06e-03 | 1.13e-03 |
| MyD88-independent TLR4 cascade | 96 | 1.33e-08 | 1.47e-07 | 0.4510 | 0.339000 | 0.225000 | -0.194000 | 8.95e-09 | 1.40e-04 | 1.01e-03 |
| TRIF(TICAM1)-mediated TLR4 signaling | 96 | 1.33e-08 | 1.47e-07 | 0.4510 | 0.339000 | 0.225000 | -0.194000 | 8.95e-09 | 1.40e-04 | 1.01e-03 |
| Formation of apoptosome | 11 | 1.57e-01 | 2.14e-01 | 0.4500 | 0.383000 | 0.233000 | -0.033200 | 2.79e-02 | 1.80e-01 | 8.49e-01 |
| Regulation of the apoptosome activity | 11 | 1.57e-01 | 2.14e-01 | 0.4500 | 0.383000 | 0.233000 | -0.033200 | 2.79e-02 | 1.80e-01 | 8.49e-01 |
| Surfactant metabolism | 21 | 4.21e-02 | 7.14e-02 | 0.4490 | 0.300000 | 0.241000 | -0.233000 | 1.75e-02 | 5.64e-02 | 6.44e-02 |
| Signaling by NOTCH | 182 | 9.75e-16 | 2.14e-14 | 0.4480 | 0.316000 | 0.221000 | -0.229000 | 1.86e-13 | 2.87e-07 | 9.96e-08 |
| RUNX1 regulates transcription of genes involved in differentiation of HSCs | 82 | 7.94e-09 | 9.15e-08 | 0.4480 | 0.356000 | 0.179000 | -0.206000 | 2.56e-08 | 5.07e-03 | 1.29e-03 |
| MAPK targets/ Nuclear events mediated by MAP kinases | 31 | 2.67e-03 | 6.93e-03 | 0.4470 | 0.349000 | 0.195000 | -0.201000 | 7.76e-04 | 6.02e-02 | 5.25e-02 |
| Nucleotide salvage | 21 | 4.11e-02 | 7.00e-02 | 0.4460 | 0.316000 | 0.227000 | -0.219000 | 1.22e-02 | 7.21e-02 | 8.23e-02 |
| EPHA-mediated growth cone collapse | 13 | 2.01e-01 | 2.62e-01 | 0.4460 | 0.287000 | 0.333000 | -0.074000 | 7.35e-02 | 3.74e-02 | 6.44e-01 |
| Ca-dependent events | 29 | 5.28e-03 | 1.22e-02 | 0.4460 | 0.246000 | 0.197000 | -0.315000 | 2.19e-02 | 6.67e-02 | 3.28e-03 |
| Signaling by NOTCH3 | 42 | 4.57e-04 | 1.52e-03 | 0.4460 | 0.247000 | 0.233000 | -0.288000 | 5.69e-03 | 8.86e-03 | 1.22e-03 |
| Signaling by EGFR in Cancer | 23 | 2.64e-03 | 6.89e-03 | 0.4460 | 0.344000 | 0.110000 | -0.261000 | 4.31e-03 | 3.62e-01 | 3.01e-02 |
| Golgi-to-ER retrograde transport | 111 | 3.62e-08 | 3.76e-07 | 0.4450 | 0.329000 | 0.290000 | -0.071700 | 1.99e-09 | 1.32e-07 | 1.92e-01 |
| Synthesis of PC | 23 | 4.46e-02 | 7.50e-02 | 0.4440 | 0.322000 | 0.302000 | 0.049500 | 7.45e-03 | 1.22e-02 | 6.81e-01 |
| Transport to the Golgi and subsequent modification | 155 | 3.07e-11 | 4.81e-10 | 0.4440 | 0.312000 | 0.298000 | -0.106000 | 1.87e-11 | 1.57e-10 | 2.33e-02 |
| Hedgehog ligand biogenesis | 58 | 4.90e-06 | 3.03e-05 | 0.4440 | 0.356000 | 0.189000 | -0.186000 | 2.66e-06 | 1.29e-02 | 1.44e-02 |
| IRE1alpha activates chaperones | 49 | 2.55e-04 | 9.11e-04 | 0.4440 | 0.268000 | 0.264000 | -0.236000 | 1.19e-03 | 1.40e-03 | 4.22e-03 |
| HIV elongation arrest and recovery | 32 | 6.33e-04 | 2.00e-03 | 0.4430 | 0.158000 | 0.050000 | -0.411000 | 1.22e-01 | 6.25e-01 | 5.78e-05 |
| Pausing and recovery of HIV elongation | 32 | 6.33e-04 | 2.00e-03 | 0.4430 | 0.158000 | 0.050000 | -0.411000 | 1.22e-01 | 6.25e-01 | 5.78e-05 |
| Vif-mediated degradation of APOBEC3G | 52 | 2.55e-06 | 1.68e-05 | 0.4420 | 0.358000 | 0.148000 | -0.214000 | 8.04e-06 | 6.48e-02 | 7.59e-03 |
| Metabolism of amine-derived hormones | 10 | 1.19e-01 | 1.72e-01 | 0.4420 | -0.193000 | -0.351000 | 0.188000 | 2.91e-01 | 5.46e-02 | 3.03e-01 |
| VEGFA-VEGFR2 Pathway | 90 | 4.19e-07 | 3.58e-06 | 0.4420 | 0.295000 | 0.261000 | -0.200000 | 1.29e-06 | 1.90e-05 | 1.02e-03 |
| Negative regulation of NOTCH4 signaling | 54 | 2.15e-06 | 1.46e-05 | 0.4420 | 0.353000 | 0.149000 | -0.220000 | 7.32e-06 | 5.76e-02 | 5.17e-03 |
| PLC beta mediated events | 43 | 6.01e-04 | 1.92e-03 | 0.4420 | 0.270000 | 0.214000 | -0.276000 | 2.19e-03 | 1.50e-02 | 1.73e-03 |
| CD28 dependent PI3K/Akt signaling | 22 | 4.03e-03 | 9.81e-03 | 0.4410 | -0.296000 | -0.190000 | -0.266000 | 1.63e-02 | 1.23e-01 | 3.07e-02 |
| Signaling by NOTCH4 | 78 | 4.41e-07 | 3.73e-06 | 0.4410 | 0.336000 | 0.206000 | -0.197000 | 2.84e-07 | 1.64e-03 | 2.61e-03 |
| Post-chaperonin tubulin folding pathway | 19 | 7.83e-02 | 1.21e-01 | 0.4400 | 0.280000 | 0.291000 | -0.174000 | 3.46e-02 | 2.80e-02 | 1.90e-01 |
| Nuclear Events (kinase and transcription factor activation) | 53 | 1.58e-04 | 6.05e-04 | 0.4400 | 0.319000 | 0.225000 | -0.202000 | 5.83e-05 | 4.61e-03 | 1.10e-02 |
| Transport of the SLBP Dependant Mature mRNA | 36 | 1.92e-03 | 5.24e-03 | 0.4390 | -0.246000 | -0.309000 | 0.192000 | 1.07e-02 | 1.31e-03 | 4.60e-02 |
| HS-GAG biosynthesis | 20 | 1.82e-02 | 3.51e-02 | 0.4390 | 0.169000 | 0.140000 | -0.381000 | 1.91e-01 | 2.79e-01 | 3.21e-03 |
| Semaphorin interactions | 57 | 4.79e-05 | 2.14e-04 | 0.4390 | 0.253000 | 0.295000 | -0.205000 | 9.61e-04 | 1.16e-04 | 7.53e-03 |
| Constitutive Signaling by AKT1 E17K in Cancer | 25 | 5.69e-03 | 1.30e-02 | 0.4380 | 0.185000 | 0.228000 | -0.326000 | 1.10e-01 | 4.88e-02 | 4.81e-03 |
| Downregulation of ERBB2:ERBB3 signaling | 12 | 6.11e-02 | 9.91e-02 | 0.4380 | 0.153000 | -0.040600 | -0.408000 | 3.57e-01 | 8.08e-01 | 1.44e-02 |
| Rap1 signalling | 13 | 1.77e-01 | 2.38e-01 | 0.4370 | 0.302000 | 0.284000 | 0.139000 | 5.98e-02 | 7.57e-02 | 3.85e-01 |
| CDC6 association with the ORC:origin complex | 11 | 5.21e-02 | 8.64e-02 | 0.4370 | -0.040600 | -0.126000 | 0.417000 | 8.16e-01 | 4.69e-01 | 1.67e-02 |
| ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 32 | 9.22e-04 | 2.76e-03 | 0.4370 | 0.242000 | 0.084700 | -0.353000 | 1.76e-02 | 4.07e-01 | 5.46e-04 |
| Acetylcholine Neurotransmitter Release Cycle | 11 | 1.03e-01 | 1.52e-01 | 0.4360 | -0.105000 | -0.135000 | -0.401000 | 5.48e-01 | 4.38e-01 | 2.12e-02 |
| Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 14 | 1.56e-01 | 2.14e-01 | 0.4350 | -0.254000 | -0.351000 | -0.030300 | 1.00e-01 | 2.28e-02 | 8.44e-01 |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane | 48 | 6.88e-04 | 2.14e-03 | 0.4340 | 0.340000 | 0.270000 | 0.007980 | 4.61e-05 | 1.19e-03 | 9.24e-01 |
| Mitochondrial translation initiation | 91 | 9.56e-19 | 2.28e-17 | 0.4340 | -0.006320 | -0.352000 | -0.254000 | 9.17e-01 | 6.45e-09 | 2.81e-05 |
| L1CAM interactions | 84 | 5.98e-06 | 3.57e-05 | 0.4340 | 0.303000 | 0.293000 | -0.104000 | 1.63e-06 | 3.36e-06 | 1.00e-01 |
| Intraflagellar transport | 39 | 2.44e-03 | 6.44e-03 | 0.4340 | -0.254000 | -0.348000 | -0.051900 | 6.11e-03 | 1.69e-04 | 5.75e-01 |
| Intrinsic Pathway of Fibrin Clot Formation | 16 | 7.93e-02 | 1.22e-01 | 0.4340 | 0.269000 | 0.165000 | -0.297000 | 6.22e-02 | 2.54e-01 | 3.95e-02 |
| Membrane Trafficking | 557 | 3.34e-38 | 1.42e-36 | 0.4340 | 0.309000 | 0.279000 | -0.123000 | 1.11e-35 | 2.10e-29 | 6.82e-07 |
| Mitochondrial translation termination | 91 | 2.28e-18 | 5.33e-17 | 0.4340 | -0.011800 | -0.352000 | -0.252000 | 8.46e-01 | 6.22e-09 | 3.17e-05 |
| Caspase activation via extrinsic apoptotic signalling pathway | 25 | 3.43e-02 | 6.00e-02 | 0.4330 | 0.304000 | 0.294000 | 0.094100 | 8.58e-03 | 1.10e-02 | 4.15e-01 |
| Interleukin-2 signaling | 11 | 7.30e-02 | 1.15e-01 | 0.4330 | 0.038700 | 0.082400 | -0.423000 | 8.24e-01 | 6.36e-01 | 1.52e-02 |
| Activation of BAD and translocation to mitochondria | 15 | 1.35e-01 | 1.90e-01 | 0.4320 | 0.310000 | 0.218000 | -0.207000 | 3.73e-02 | 1.44e-01 | 1.65e-01 |
| Interferon alpha/beta signaling | 57 | 2.93e-10 | 4.02e-09 | 0.4320 | -0.283000 | 0.030400 | 0.325000 | 2.20e-04 | 6.92e-01 | 2.19e-05 |
| IKK complex recruitment mediated by RIP1 | 23 | 2.86e-02 | 5.18e-02 | 0.4320 | 0.357000 | 0.237000 | -0.052200 | 3.03e-03 | 4.90e-02 | 6.65e-01 |
| Rab regulation of trafficking | 120 | 4.23e-09 | 5.19e-08 | 0.4310 | 0.269000 | 0.290000 | -0.172000 | 3.41e-07 | 4.26e-08 | 1.16e-03 |
| G-protein mediated events | 44 | 6.45e-04 | 2.03e-03 | 0.4310 | 0.252000 | 0.210000 | -0.279000 | 3.80e-03 | 1.58e-02 | 1.36e-03 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | 28 | 1.61e-02 | 3.16e-02 | 0.4310 | -0.259000 | -0.301000 | -0.167000 | 1.77e-02 | 5.84e-03 | 1.27e-01 |
| Integration of energy metabolism | 86 | 2.13e-06 | 1.45e-05 | 0.4300 | 0.287000 | 0.262000 | -0.185000 | 4.19e-06 | 2.61e-05 | 3.07e-03 |
| Activation of G protein gated Potassium channels | 19 | 7.36e-02 | 1.15e-01 | 0.4300 | 0.323000 | 0.270000 | 0.086300 | 1.48e-02 | 4.13e-02 | 5.15e-01 |
| G protein gated Potassium channels | 19 | 7.36e-02 | 1.15e-01 | 0.4300 | 0.323000 | 0.270000 | 0.086300 | 1.48e-02 | 4.13e-02 | 5.15e-01 |
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 19 | 7.36e-02 | 1.15e-01 | 0.4300 | 0.323000 | 0.270000 | 0.086300 | 1.48e-02 | 4.13e-02 | 5.15e-01 |
| Degradation of GLI2 by the proteasome | 56 | 1.11e-06 | 8.17e-06 | 0.4290 | 0.349000 | 0.135000 | -0.210000 | 6.06e-06 | 8.09e-02 | 6.66e-03 |
| G beta:gamma signalling through BTK | 15 | 1.89e-01 | 2.49e-01 | 0.4290 | 0.322000 | 0.282000 | -0.032000 | 3.09e-02 | 5.88e-02 | 8.30e-01 |
| Oncogenic MAPK signaling | 73 | 1.68e-05 | 8.60e-05 | 0.4290 | 0.334000 | 0.252000 | -0.095200 | 8.24e-07 | 1.93e-04 | 1.59e-01 |
| Regulation of PTEN stability and activity | 66 | 6.60e-06 | 3.89e-05 | 0.4290 | 0.341000 | 0.202000 | -0.164000 | 1.63e-06 | 4.53e-03 | 2.15e-02 |
| Vpu mediated degradation of CD4 | 50 | 1.38e-06 | 9.89e-06 | 0.4280 | 0.342000 | 0.103000 | -0.237000 | 2.94e-05 | 2.07e-01 | 3.70e-03 |
| Signaling by NOTCH1 | 66 | 1.64e-05 | 8.43e-05 | 0.4280 | 0.284000 | 0.199000 | -0.250000 | 6.56e-05 | 5.20e-03 | 4.41e-04 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | 55 | 1.55e-04 | 5.96e-04 | 0.4270 | 0.246000 | 0.348000 | 0.033100 | 1.62e-03 | 8.02e-06 | 6.71e-01 |
| Cytochrome c-mediated apoptotic response | 13 | 1.23e-01 | 1.76e-01 | 0.4260 | 0.339000 | 0.232000 | 0.113000 | 3.44e-02 | 1.47e-01 | 4.79e-01 |
| tRNA processing | 134 | 5.80e-10 | 7.66e-09 | 0.4260 | -0.256000 | -0.336000 | -0.050800 | 3.12e-07 | 1.72e-11 | 3.10e-01 |
| ER Quality Control Compartment (ERQC) | 21 | 4.67e-02 | 7.80e-02 | 0.4260 | 0.333000 | 0.211000 | -0.162000 | 8.31e-03 | 9.46e-02 | 2.00e-01 |
| Carnitine metabolism | 10 | 2.94e-01 | 3.59e-01 | 0.4250 | 0.281000 | 0.201000 | -0.248000 | 1.24e-01 | 2.72e-01 | 1.74e-01 |
| Vasopressin regulates renal water homeostasis via Aquaporins | 34 | 7.96e-03 | 1.74e-02 | 0.4250 | 0.291000 | 0.225000 | -0.213000 | 3.36e-03 | 2.29e-02 | 3.17e-02 |
| Metabolism of porphyrins | 22 | 6.38e-02 | 1.03e-01 | 0.4250 | 0.310000 | 0.245000 | -0.156000 | 1.18e-02 | 4.70e-02 | 2.05e-01 |
| Mismatch Repair | 15 | 1.34e-01 | 1.89e-01 | 0.4250 | -0.242000 | -0.349000 | -0.001240 | 1.05e-01 | 1.93e-02 | 9.93e-01 |
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | 50 | 4.12e-06 | 2.60e-05 | 0.4250 | 0.345000 | 0.123000 | -0.214000 | 2.40e-05 | 1.32e-01 | 8.71e-03 |
| p53-Independent DNA Damage Response | 50 | 4.12e-06 | 2.60e-05 | 0.4250 | 0.345000 | 0.123000 | -0.214000 | 2.40e-05 | 1.32e-01 | 8.71e-03 |
| p53-Independent G1/S DNA damage checkpoint | 50 | 4.12e-06 | 2.60e-05 | 0.4250 | 0.345000 | 0.123000 | -0.214000 | 2.40e-05 | 1.32e-01 | 8.71e-03 |
| Regulation of Apoptosis | 51 | 3.41e-06 | 2.19e-05 | 0.4250 | 0.357000 | 0.137000 | -0.184000 | 1.01e-05 | 9.17e-02 | 2.29e-02 |
| Mitochondrial protein import | 64 | 3.30e-12 | 5.68e-11 | 0.4240 | 0.034300 | -0.294000 | -0.304000 | 6.35e-01 | 4.86e-05 | 2.56e-05 |
| G alpha (z) signalling events | 36 | 4.88e-03 | 1.15e-02 | 0.4240 | 0.275000 | 0.214000 | -0.241000 | 4.27e-03 | 2.63e-02 | 1.25e-02 |
| PPARA activates gene expression | 104 | 2.36e-07 | 2.10e-06 | 0.4230 | 0.270000 | 0.315000 | -0.085700 | 2.03e-06 | 2.92e-08 | 1.31e-01 |
| RNA Polymerase III Chain Elongation | 18 | 5.53e-02 | 9.11e-02 | 0.4230 | -0.189000 | -0.316000 | -0.207000 | 1.64e-01 | 2.03e-02 | 1.28e-01 |
| CD22 mediated BCR regulation | 59 | 2.85e-08 | 3.03e-07 | 0.4230 | -0.135000 | -0.293000 | 0.273000 | 7.25e-02 | 9.76e-05 | 2.91e-04 |
| Uptake and actions of bacterial toxins | 27 | 2.29e-02 | 4.29e-02 | 0.4230 | 0.306000 | 0.215000 | -0.198000 | 5.95e-03 | 5.35e-02 | 7.56e-02 |
| Misspliced GSK3beta mutants stabilize beta-catenin | 15 | 2.03e-01 | 2.63e-01 | 0.4230 | 0.287000 | 0.295000 | -0.094000 | 5.40e-02 | 4.78e-02 | 5.28e-01 |
| S33 mutants of beta-catenin aren't phosphorylated | 15 | 2.03e-01 | 2.63e-01 | 0.4230 | 0.287000 | 0.295000 | -0.094000 | 5.40e-02 | 4.78e-02 | 5.28e-01 |
| S37 mutants of beta-catenin aren't phosphorylated | 15 | 2.03e-01 | 2.63e-01 | 0.4230 | 0.287000 | 0.295000 | -0.094000 | 5.40e-02 | 4.78e-02 | 5.28e-01 |
| S45 mutants of beta-catenin aren't phosphorylated | 15 | 2.03e-01 | 2.63e-01 | 0.4230 | 0.287000 | 0.295000 | -0.094000 | 5.40e-02 | 4.78e-02 | 5.28e-01 |
| T41 mutants of beta-catenin aren't phosphorylated | 15 | 2.03e-01 | 2.63e-01 | 0.4230 | 0.287000 | 0.295000 | -0.094000 | 5.40e-02 | 4.78e-02 | 5.28e-01 |
| phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | 15 | 2.03e-01 | 2.63e-01 | 0.4230 | 0.287000 | 0.295000 | -0.094000 | 5.40e-02 | 4.78e-02 | 5.28e-01 |
| TRAF6 mediated NF-kB activation | 23 | 4.48e-02 | 7.52e-02 | 0.4220 | 0.270000 | 0.224000 | -0.234000 | 2.48e-02 | 6.32e-02 | 5.19e-02 |
| Ubiquitin-dependent degradation of Cyclin D | 50 | 1.01e-05 | 5.54e-05 | 0.4210 | 0.331000 | 0.125000 | -0.228000 | 5.00e-05 | 1.27e-01 | 5.27e-03 |
| ABC transporter disorders | 70 | 6.71e-07 | 5.22e-06 | 0.4200 | 0.318000 | 0.147000 | -0.230000 | 4.11e-06 | 3.33e-02 | 8.62e-04 |
| p75NTR recruits signalling complexes | 12 | 1.16e-01 | 1.68e-01 | 0.4190 | 0.246000 | 0.075900 | -0.331000 | 1.40e-01 | 6.49e-01 | 4.72e-02 |
| Signaling by Insulin receptor | 59 | 1.24e-04 | 4.92e-04 | 0.4190 | 0.295000 | 0.208000 | -0.212000 | 8.65e-05 | 5.69e-03 | 4.84e-03 |
| Interleukin-10 signaling | 34 | 1.17e-02 | 2.39e-02 | 0.4190 | 0.307000 | 0.238000 | -0.157000 | 1.94e-03 | 1.64e-02 | 1.14e-01 |
| Mitophagy | 28 | 9.48e-06 | 5.33e-05 | 0.4180 | 0.184000 | -0.161000 | -0.339000 | 9.21e-02 | 1.40e-01 | 1.90e-03 |
| Mitochondrial translation | 97 | 1.55e-19 | 3.97e-18 | 0.4180 | 0.002610 | -0.344000 | -0.237000 | 9.65e-01 | 4.79e-09 | 5.49e-05 |
| GLI3 is processed to GLI3R by the proteasome | 57 | 1.22e-06 | 8.93e-06 | 0.4180 | 0.333000 | 0.117000 | -0.223000 | 1.37e-05 | 1.25e-01 | 3.60e-03 |
| Classical antibody-mediated complement activation | 69 | 1.76e-08 | 1.89e-07 | 0.4170 | -0.135000 | -0.242000 | 0.312000 | 5.18e-02 | 5.10e-04 | 7.32e-06 |
| Degradation of GLI1 by the proteasome | 57 | 4.10e-06 | 2.60e-05 | 0.4170 | 0.344000 | 0.149000 | -0.183000 | 6.83e-06 | 5.23e-02 | 1.69e-02 |
| Cleavage of the damaged pyrimidine | 29 | 4.93e-03 | 1.15e-02 | 0.4170 | 0.274000 | 0.121000 | -0.290000 | 1.06e-02 | 2.61e-01 | 6.82e-03 |
| Depyrimidination | 29 | 4.93e-03 | 1.15e-02 | 0.4170 | 0.274000 | 0.121000 | -0.290000 | 1.06e-02 | 2.61e-01 | 6.82e-03 |
| Recognition and association of DNA glycosylase with site containing an affected pyrimidine | 29 | 4.93e-03 | 1.15e-02 | 0.4170 | 0.274000 | 0.121000 | -0.290000 | 1.06e-02 | 2.61e-01 | 6.82e-03 |
| Opioid Signalling | 75 | 2.06e-05 | 1.01e-04 | 0.4170 | 0.287000 | 0.233000 | -0.192000 | 1.69e-05 | 4.84e-04 | 3.99e-03 |
| NIK-->noncanonical NF-kB signaling | 57 | 6.50e-07 | 5.13e-06 | 0.4160 | 0.339000 | 0.112000 | -0.214000 | 9.72e-06 | 1.44e-01 | 5.18e-03 |
| Base-Excision Repair, AP Site Formation | 31 | 3.24e-03 | 8.11e-03 | 0.4160 | 0.252000 | 0.108000 | -0.313000 | 1.51e-02 | 3.00e-01 | 2.57e-03 |
| Endogenous sterols | 16 | 1.31e-01 | 1.86e-01 | 0.4160 | 0.319000 | 0.210000 | -0.163000 | 2.69e-02 | 1.46e-01 | 2.60e-01 |
| Dectin-1 mediated noncanonical NF-kB signaling | 58 | 6.22e-07 | 4.98e-06 | 0.4150 | 0.332000 | 0.109000 | -0.225000 | 1.21e-05 | 1.52e-01 | 3.09e-03 |
| Cytosolic tRNA aminoacylation | 24 | 6.45e-04 | 2.03e-03 | 0.4150 | -0.130000 | -0.355000 | 0.172000 | 2.71e-01 | 2.64e-03 | 1.46e-01 |
| Activation of GABAB receptors | 30 | 3.31e-02 | 5.80e-02 | 0.4140 | 0.284000 | 0.294000 | -0.065000 | 7.09e-03 | 5.31e-03 | 5.38e-01 |
| GABA B receptor activation | 30 | 3.31e-02 | 5.80e-02 | 0.4140 | 0.284000 | 0.294000 | -0.065000 | 7.09e-03 | 5.31e-03 | 5.38e-01 |
| Triglyceride catabolism | 16 | 1.80e-01 | 2.40e-01 | 0.4140 | 0.317000 | 0.255000 | -0.076900 | 2.82e-02 | 7.74e-02 | 5.94e-01 |
| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 52 | 5.52e-06 | 3.34e-05 | 0.4140 | 0.350000 | 0.136000 | -0.173000 | 1.24e-05 | 8.94e-02 | 3.10e-02 |
| Other semaphorin interactions | 16 | 7.12e-02 | 1.13e-01 | 0.4130 | 0.165000 | 0.145000 | -0.350000 | 2.53e-01 | 3.16e-01 | 1.54e-02 |
| Degradation of the extracellular matrix | 77 | 5.45e-06 | 3.31e-05 | 0.4130 | 0.236000 | 0.269000 | -0.206000 | 3.38e-04 | 4.55e-05 | 1.78e-03 |
| Autophagy | 124 | 1.20e-10 | 1.67e-09 | 0.4130 | 0.310000 | 0.166000 | -0.215000 | 2.38e-09 | 1.40e-03 | 3.45e-05 |
| Glycosaminoglycan metabolism | 92 | 2.48e-09 | 3.09e-08 | 0.4120 | 0.149000 | 0.177000 | -0.341000 | 1.33e-02 | 3.41e-03 | 1.50e-08 |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | 20 | 2.41e-02 | 4.49e-02 | 0.4120 | 0.124000 | 0.101000 | -0.380000 | 3.38e-01 | 4.36e-01 | 3.29e-03 |
| G-protein activation | 23 | 6.29e-02 | 1.02e-01 | 0.4120 | 0.325000 | 0.247000 | -0.052900 | 6.91e-03 | 4.05e-02 | 6.61e-01 |
| PIWI-interacting RNA (piRNA) biogenesis | 23 | 2.60e-03 | 6.78e-03 | 0.4120 | 0.039600 | -0.187000 | -0.364000 | 7.42e-01 | 1.20e-01 | 2.49e-03 |
| Cell recruitment (pro-inflammatory response) | 22 | 6.92e-03 | 1.54e-02 | 0.4100 | 0.359000 | 0.132000 | -0.148000 | 3.55e-03 | 2.84e-01 | 2.30e-01 |
| Purinergic signaling in leishmaniasis infection | 22 | 6.92e-03 | 1.54e-02 | 0.4100 | 0.359000 | 0.132000 | -0.148000 | 3.55e-03 | 2.84e-01 | 2.30e-01 |
| NOTCH3 Intracellular Domain Regulates Transcription | 20 | 1.02e-01 | 1.51e-01 | 0.4080 | 0.257000 | 0.283000 | -0.144000 | 4.69e-02 | 2.84e-02 | 2.65e-01 |
| Removal of the Flap Intermediate from the C-strand | 17 | 1.04e-01 | 1.53e-01 | 0.4080 | -0.216000 | -0.335000 | -0.089600 | 1.24e-01 | 1.69e-02 | 5.22e-01 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | 25 | 1.50e-02 | 2.99e-02 | 0.4080 | 0.203000 | 0.354000 | -0.005050 | 7.89e-02 | 2.19e-03 | 9.65e-01 |
| RNA Polymerase I Transcription Initiation | 47 | 4.95e-04 | 1.63e-03 | 0.4080 | -0.209000 | -0.341000 | -0.080400 | 1.31e-02 | 5.26e-05 | 3.40e-01 |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | 27 | 2.94e-02 | 5.28e-02 | 0.4080 | -0.248000 | -0.279000 | -0.164000 | 2.56e-02 | 1.22e-02 | 1.40e-01 |
| Nuclear signaling by ERBB4 | 24 | 1.59e-02 | 3.12e-02 | 0.4070 | 0.243000 | 0.099900 | -0.311000 | 3.92e-02 | 3.97e-01 | 8.29e-03 |
| Activation of gene expression by SREBF (SREBP) | 42 | 2.69e-03 | 6.97e-03 | 0.4070 | 0.236000 | 0.330000 | -0.037000 | 8.13e-03 | 2.19e-04 | 6.79e-01 |
| Response of EIF2AK1 (HRI) to heme deficiency | 14 | 1.79e-02 | 3.46e-02 | 0.4050 | 0.369000 | 0.132000 | 0.103000 | 1.68e-02 | 3.91e-01 | 5.03e-01 |
| Regulation of lipid metabolism by PPARalpha | 106 | 4.99e-07 | 4.11e-06 | 0.4050 | 0.254000 | 0.303000 | -0.089800 | 6.09e-06 | 7.16e-08 | 1.10e-01 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | 14 | 5.59e-02 | 9.15e-02 | 0.4050 | 0.027700 | 0.049800 | -0.401000 | 8.58e-01 | 7.47e-01 | 9.33e-03 |
| Signaling by NOTCH1 HD Domain Mutants in Cancer | 14 | 5.59e-02 | 9.15e-02 | 0.4050 | 0.027700 | 0.049800 | -0.401000 | 8.58e-01 | 7.47e-01 | 9.33e-03 |
| GABA receptor activation | 35 | 1.99e-02 | 3.81e-02 | 0.4040 | 0.270000 | 0.299000 | -0.034800 | 5.78e-03 | 2.20e-03 | 7.22e-01 |
| NOTCH1 Intracellular Domain Regulates Transcription | 44 | 4.13e-04 | 1.40e-03 | 0.4030 | 0.297000 | 0.137000 | -0.236000 | 6.57e-04 | 1.15e-01 | 6.76e-03 |
| The citric acid (TCA) cycle and respiratory electron transport | 172 | 9.90e-23 | 2.64e-21 | 0.4030 | 0.239000 | -0.010500 | -0.325000 | 6.56e-08 | 8.11e-01 | 1.97e-13 |
| Toll Like Receptor 3 (TLR3) Cascade | 92 | 7.85e-07 | 6.07e-06 | 0.4030 | 0.299000 | 0.190000 | -0.193000 | 7.41e-07 | 1.64e-03 | 1.40e-03 |
| PI3K events in ERBB2 signaling | 11 | 5.96e-02 | 9.66e-02 | 0.4030 | 0.247000 | -0.026300 | -0.317000 | 1.55e-01 | 8.80e-01 | 6.90e-02 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 29 | 6.86e-05 | 2.94e-04 | 0.4020 | 0.318000 | 0.012600 | -0.246000 | 3.06e-03 | 9.07e-01 | 2.20e-02 |
| CaM pathway | 27 | 1.58e-02 | 3.12e-02 | 0.4020 | 0.198000 | 0.144000 | -0.318000 | 7.51e-02 | 1.96e-01 | 4.18e-03 |
| Calmodulin induced events | 27 | 1.58e-02 | 3.12e-02 | 0.4020 | 0.198000 | 0.144000 | -0.318000 | 7.51e-02 | 1.96e-01 | 4.18e-03 |
| Recognition of DNA damage by PCNA-containing replication complex | 30 | 2.94e-03 | 7.54e-03 | 0.4010 | -0.165000 | -0.353000 | -0.094600 | 1.18e-01 | 8.16e-04 | 3.70e-01 |
| Effects of PIP2 hydrolysis | 24 | 4.55e-03 | 1.08e-02 | 0.4010 | -0.307000 | -0.167000 | -0.197000 | 9.19e-03 | 1.57e-01 | 9.55e-02 |
| Condensation of Prophase Chromosomes | 29 | 1.48e-02 | 2.97e-02 | 0.4010 | 0.304000 | 0.172000 | -0.196000 | 4.63e-03 | 1.08e-01 | 6.70e-02 |
| Autodegradation of the E3 ubiquitin ligase COP1 | 49 | 2.22e-05 | 1.08e-04 | 0.4010 | 0.316000 | 0.107000 | -0.222000 | 1.29e-04 | 1.96e-01 | 7.23e-03 |
| Signaling by VEGF | 97 | 1.48e-06 | 1.05e-05 | 0.4000 | 0.254000 | 0.231000 | -0.206000 | 1.50e-05 | 8.63e-05 | 4.51e-04 |
| Chondroitin sulfate/dermatan sulfate metabolism | 38 | 5.19e-04 | 1.69e-03 | 0.3990 | 0.079200 | 0.049300 | -0.388000 | 3.98e-01 | 5.99e-01 | 3.56e-05 |
| Listeria monocytogenes entry into host cells | 17 | 1.44e-01 | 2.00e-01 | 0.3990 | 0.243000 | 0.218000 | -0.228000 | 8.26e-02 | 1.19e-01 | 1.04e-01 |
| Metabolism of steroid hormones | 19 | 1.27e-01 | 1.81e-01 | 0.3980 | 0.311000 | 0.228000 | -0.099100 | 1.87e-02 | 8.57e-02 | 4.55e-01 |
| Disorders of developmental biology | 12 | 2.00e-01 | 2.61e-01 | 0.3980 | 0.180000 | 0.170000 | -0.311000 | 2.79e-01 | 3.07e-01 | 6.18e-02 |
| Loss of function of MECP2 in Rett syndrome | 12 | 2.00e-01 | 2.61e-01 | 0.3980 | 0.180000 | 0.170000 | -0.311000 | 2.79e-01 | 3.07e-01 | 6.18e-02 |
| Pervasive developmental disorders | 12 | 2.00e-01 | 2.61e-01 | 0.3980 | 0.180000 | 0.170000 | -0.311000 | 2.79e-01 | 3.07e-01 | 6.18e-02 |
| IRAK2 mediated activation of TAK1 complex | 10 | 1.58e-01 | 2.16e-01 | 0.3980 | 0.254000 | 0.042000 | -0.303000 | 1.64e-01 | 8.18e-01 | 9.66e-02 |
| Regulation of RUNX3 expression and activity | 55 | 3.32e-05 | 1.55e-04 | 0.3980 | 0.307000 | 0.131000 | -0.217000 | 8.41e-05 | 9.28e-02 | 5.39e-03 |
| Creation of C4 and C2 activators | 71 | 3.90e-08 | 4.02e-07 | 0.3970 | -0.123000 | -0.231000 | 0.299000 | 7.29e-02 | 7.66e-04 | 1.36e-05 |
| Prefoldin mediated transfer of substrate to CCT/TriC | 26 | 6.73e-05 | 2.91e-04 | 0.3960 | 0.289000 | -0.044500 | -0.268000 | 1.08e-02 | 6.94e-01 | 1.81e-02 |
| MET promotes cell motility | 26 | 6.86e-02 | 1.09e-01 | 0.3950 | 0.294000 | 0.264000 | 0.008440 | 9.47e-03 | 2.00e-02 | 9.41e-01 |
| Oxidative Stress Induced Senescence | 79 | 8.81e-06 | 5.03e-05 | 0.3950 | 0.270000 | 0.173000 | -0.230000 | 3.35e-05 | 7.93e-03 | 4.05e-04 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | 17 | 1.43e-01 | 1.99e-01 | 0.3940 | 0.295000 | 0.192000 | -0.176000 | 3.51e-02 | 1.71e-01 | 2.08e-01 |
| Regulation of IFNA signaling | 12 | 1.74e-01 | 2.35e-01 | 0.3930 | 0.185000 | 0.346000 | 0.009230 | 2.66e-01 | 3.77e-02 | 9.56e-01 |
| Platelet homeostasis | 69 | 3.20e-04 | 1.12e-03 | 0.3920 | 0.279000 | 0.243000 | -0.129000 | 5.95e-05 | 4.71e-04 | 6.38e-02 |
| Activation of NF-kappaB in B cells | 65 | 4.17e-06 | 2.61e-05 | 0.3920 | 0.307000 | 0.126000 | -0.210000 | 1.91e-05 | 7.96e-02 | 3.48e-03 |
| NRIF signals cell death from the nucleus | 15 | 1.02e-01 | 1.51e-01 | 0.3910 | 0.217000 | 0.074600 | -0.317000 | 1.46e-01 | 6.17e-01 | 3.34e-02 |
| TGF-beta receptor signaling activates SMADs | 32 | 9.12e-03 | 1.97e-02 | 0.3910 | 0.270000 | 0.141000 | -0.244000 | 8.14e-03 | 1.67e-01 | 1.68e-02 |
| Diseases associated with glycosylation precursor biosynthesis | 18 | 1.68e-01 | 2.29e-01 | 0.3900 | 0.290000 | 0.224000 | -0.136000 | 3.34e-02 | 1.00e-01 | 3.18e-01 |
| Signaling by Receptor Tyrosine Kinases | 411 | 1.57e-25 | 4.63e-24 | 0.3900 | 0.261000 | 0.210000 | -0.200000 | 1.01e-19 | 2.69e-13 | 3.64e-12 |
| Metabolism of polyamines | 57 | 2.27e-06 | 1.52e-05 | 0.3900 | 0.330000 | 0.108000 | -0.179000 | 1.67e-05 | 1.60e-01 | 1.97e-02 |
| Biosynthesis of specialized proresolving mediators (SPMs) | 16 | 2.07e-01 | 2.67e-01 | 0.3900 | 0.287000 | 0.216000 | -0.151000 | 4.69e-02 | 1.35e-01 | 2.95e-01 |
| Interleukin-27 signaling | 11 | 3.47e-01 | 4.17e-01 | 0.3900 | 0.276000 | 0.251000 | 0.112000 | 1.13e-01 | 1.49e-01 | 5.20e-01 |
| Termination of translesion DNA synthesis | 32 | 1.08e-02 | 2.25e-02 | 0.3890 | -0.206000 | -0.329000 | 0.016700 | 4.40e-02 | 1.27e-03 | 8.70e-01 |
| SARS-CoV-1 Infection | 47 | 2.59e-03 | 6.78e-03 | 0.3870 | 0.244000 | 0.194000 | -0.230000 | 3.87e-03 | 2.13e-02 | 6.37e-03 |
| Chaperone Mediated Autophagy | 20 | 9.83e-03 | 2.11e-02 | 0.3860 | 0.214000 | -0.024400 | -0.320000 | 9.77e-02 | 8.50e-01 | 1.31e-02 |
| PKA-mediated phosphorylation of CREB | 17 | 9.61e-02 | 1.44e-01 | 0.3860 | 0.185000 | 0.101000 | -0.323000 | 1.86e-01 | 4.73e-01 | 2.10e-02 |
| Interleukin-15 signaling | 14 | 2.61e-01 | 3.25e-01 | 0.3860 | 0.238000 | 0.248000 | -0.175000 | 1.23e-01 | 1.08e-01 | 2.56e-01 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | 11 | 1.78e-01 | 2.40e-01 | 0.3860 | -0.020900 | -0.147000 | -0.356000 | 9.05e-01 | 3.99e-01 | 4.09e-02 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 32 | 4.07e-02 | 6.96e-02 | 0.3860 | 0.272000 | 0.247000 | -0.117000 | 7.77e-03 | 1.55e-02 | 2.51e-01 |
| CLEC7A (Dectin-1) signaling | 96 | 1.43e-08 | 1.56e-07 | 0.3850 | 0.309000 | 0.130000 | -0.189000 | 1.70e-07 | 2.77e-02 | 1.38e-03 |
| Transport of Mature mRNA Derived from an Intronless Transcript | 42 | 9.70e-03 | 2.08e-02 | 0.3840 | -0.248000 | -0.247000 | 0.158000 | 5.35e-03 | 5.54e-03 | 7.72e-02 |
| Transcriptional regulation of white adipocyte differentiation | 77 | 1.68e-04 | 6.35e-04 | 0.3830 | 0.250000 | 0.272000 | -0.099400 | 1.48e-04 | 3.57e-05 | 1.32e-01 |
| The role of GTSE1 in G2/M progression after G2 checkpoint | 58 | 5.17e-06 | 3.15e-05 | 0.3820 | 0.331000 | 0.122000 | -0.147000 | 1.31e-05 | 1.07e-01 | 5.23e-02 |
| Nef mediated downregulation of MHC class I complex cell surface expression | 10 | 1.69e-01 | 2.29e-01 | 0.3820 | 0.172000 | -0.029900 | -0.339000 | 3.45e-01 | 8.70e-01 | 6.31e-02 |
| Citric acid cycle (TCA cycle) | 22 | 6.72e-02 | 1.07e-01 | 0.3790 | 0.269000 | 0.152000 | -0.220000 | 2.92e-02 | 2.17e-01 | 7.37e-02 |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 53 | 1.89e-03 | 5.16e-03 | 0.3790 | 0.256000 | 0.195000 | -0.200000 | 1.26e-03 | 1.40e-02 | 1.18e-02 |
| Plasma lipoprotein remodeling | 18 | 1.56e-01 | 2.14e-01 | 0.3790 | 0.222000 | 0.290000 | -0.101000 | 1.03e-01 | 3.34e-02 | 4.57e-01 |
| Asparagine N-linked glycosylation | 269 | 1.05e-14 | 2.17e-13 | 0.3790 | 0.276000 | 0.227000 | -0.126000 | 6.90e-15 | 1.44e-10 | 3.95e-04 |
| Condensation of Prometaphase Chromosomes | 11 | 1.79e-01 | 2.40e-01 | 0.3770 | 0.096300 | 0.093900 | 0.353000 | 5.80e-01 | 5.90e-01 | 4.28e-02 |
| Signaling by SCF-KIT | 40 | 1.64e-02 | 3.21e-02 | 0.3770 | 0.245000 | 0.251000 | -0.137000 | 7.31e-03 | 6.08e-03 | 1.33e-01 |
| Oncogene Induced Senescence | 33 | 2.56e-02 | 4.71e-02 | 0.3760 | 0.226000 | 0.225000 | -0.199000 | 2.44e-02 | 2.52e-02 | 4.74e-02 |
| Signaling by Non-Receptor Tyrosine Kinases | 48 | 1.87e-03 | 5.11e-03 | 0.3760 | 0.277000 | 0.162000 | -0.195000 | 9.02e-04 | 5.19e-02 | 1.92e-02 |
| Signaling by PTK6 | 48 | 1.87e-03 | 5.11e-03 | 0.3760 | 0.277000 | 0.162000 | -0.195000 | 9.02e-04 | 5.19e-02 | 1.92e-02 |
| SARS-CoV Infections | 83 | 5.45e-05 | 2.41e-04 | 0.3760 | 0.251000 | 0.205000 | -0.190000 | 7.89e-05 | 1.23e-03 | 2.72e-03 |
| E3 ubiquitin ligases ubiquitinate target proteins | 52 | 7.38e-05 | 3.15e-04 | 0.3760 | 0.322000 | 0.135000 | -0.138000 | 5.75e-05 | 9.29e-02 | 8.61e-02 |
| Acyl chain remodelling of PI | 10 | 3.77e-01 | 4.44e-01 | 0.3760 | 0.301000 | 0.180000 | -0.134000 | 9.92e-02 | 3.24e-01 | 4.64e-01 |
| Signaling by Interleukins | 383 | 4.27e-23 | 1.16e-21 | 0.3750 | 0.270000 | 0.184000 | -0.184000 | 9.51e-20 | 6.07e-10 | 6.85e-10 |
| Protein ubiquitination | 72 | 1.28e-06 | 9.31e-06 | 0.3750 | 0.317000 | 0.128000 | -0.154000 | 3.21e-06 | 6.03e-02 | 2.42e-02 |
| RUNX3 regulates NOTCH signaling | 14 | 2.22e-01 | 2.83e-01 | 0.3740 | 0.204000 | 0.285000 | -0.130000 | 1.87e-01 | 6.45e-02 | 3.98e-01 |
| Assembly of active LPL and LIPC lipase complexes | 10 | 3.76e-01 | 4.43e-01 | 0.3740 | 0.204000 | 0.274000 | -0.152000 | 2.64e-01 | 1.34e-01 | 4.05e-01 |
| Defective B3GAT3 causes JDSSDHD | 11 | 2.07e-01 | 2.67e-01 | 0.3730 | -0.008330 | -0.110000 | -0.357000 | 9.62e-01 | 5.28e-01 | 4.04e-02 |
| SUMOylation of SUMOylation proteins | 35 | 1.65e-02 | 3.22e-02 | 0.3730 | -0.212000 | -0.276000 | 0.135000 | 3.00e-02 | 4.78e-03 | 1.67e-01 |
| SUMOylation of DNA methylation proteins | 16 | 8.48e-02 | 1.29e-01 | 0.3730 | -0.040500 | -0.170000 | -0.329000 | 7.79e-01 | 2.40e-01 | 2.25e-02 |
| Degradation of AXIN | 53 | 1.52e-04 | 5.88e-04 | 0.3720 | 0.290000 | 0.120000 | -0.201000 | 2.66e-04 | 1.32e-01 | 1.14e-02 |
| Signaling by PDGFRA extracellular domain mutants | 12 | 2.37e-01 | 2.98e-01 | 0.3720 | 0.287000 | 0.198000 | 0.129000 | 8.47e-02 | 2.36e-01 | 4.40e-01 |
| Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 12 | 2.37e-01 | 2.98e-01 | 0.3720 | 0.287000 | 0.198000 | 0.129000 | 8.47e-02 | 2.36e-01 | 4.40e-01 |
| Myogenesis | 21 | 1.77e-01 | 2.38e-01 | 0.3720 | 0.270000 | 0.246000 | -0.067600 | 3.23e-02 | 5.06e-02 | 5.92e-01 |
| SHC1 events in ERBB4 signaling | 10 | 1.22e-01 | 1.76e-01 | 0.3710 | 0.331000 | 0.075100 | -0.149000 | 6.96e-02 | 6.81e-01 | 4.13e-01 |
| Transcriptional Regulation by E2F6 | 34 | 1.90e-02 | 3.65e-02 | 0.3710 | -0.210000 | -0.275000 | 0.135000 | 3.44e-02 | 5.51e-03 | 1.75e-01 |
| mRNA Splicing - Minor Pathway | 52 | 1.49e-06 | 1.05e-05 | 0.3710 | 0.045100 | -0.199000 | -0.310000 | 5.74e-01 | 1.30e-02 | 1.11e-04 |
| AMER1 mutants destabilize the destruction complex | 14 | 3.51e-01 | 4.18e-01 | 0.3710 | 0.257000 | 0.256000 | -0.076800 | 9.63e-02 | 9.68e-02 | 6.19e-01 |
| APC truncation mutants have impaired AXIN binding | 14 | 3.51e-01 | 4.18e-01 | 0.3710 | 0.257000 | 0.256000 | -0.076800 | 9.63e-02 | 9.68e-02 | 6.19e-01 |
| AXIN missense mutants destabilize the destruction complex | 14 | 3.51e-01 | 4.18e-01 | 0.3710 | 0.257000 | 0.256000 | -0.076800 | 9.63e-02 | 9.68e-02 | 6.19e-01 |
| AXIN mutants destabilize the destruction complex, activating WNT signaling | 14 | 3.51e-01 | 4.18e-01 | 0.3710 | 0.257000 | 0.256000 | -0.076800 | 9.63e-02 | 9.68e-02 | 6.19e-01 |
| Truncations of AMER1 destabilize the destruction complex | 14 | 3.51e-01 | 4.18e-01 | 0.3710 | 0.257000 | 0.256000 | -0.076800 | 9.63e-02 | 9.68e-02 | 6.19e-01 |
| truncated APC mutants destabilize the destruction complex | 14 | 3.51e-01 | 4.18e-01 | 0.3710 | 0.257000 | 0.256000 | -0.076800 | 9.63e-02 | 9.68e-02 | 6.19e-01 |
| p38MAPK events | 13 | 2.41e-01 | 3.02e-01 | 0.3700 | 0.298000 | 0.162000 | -0.149000 | 6.29e-02 | 3.11e-01 | 3.53e-01 |
| Initial triggering of complement | 78 | 2.25e-07 | 2.01e-06 | 0.3700 | -0.116000 | -0.193000 | 0.294000 | 7.63e-02 | 3.26e-03 | 7.02e-06 |
| Signaling by FGFR2 IIIa TM | 18 | 2.18e-02 | 4.12e-02 | 0.3700 | 0.141000 | -0.086700 | -0.331000 | 3.02e-01 | 5.24e-01 | 1.50e-02 |
| Transport of Mature mRNAs Derived from Intronless Transcripts | 43 | 1.06e-02 | 2.23e-02 | 0.3700 | -0.228000 | -0.249000 | 0.151000 | 9.62e-03 | 4.74e-03 | 8.71e-02 |
| TRAF6 mediated IRF7 activation | 15 | 1.04e-01 | 1.53e-01 | 0.3690 | 0.065700 | 0.219000 | 0.290000 | 6.59e-01 | 1.43e-01 | 5.20e-02 |
| NR1H2 and NR1H3-mediated signaling | 39 | 7.26e-03 | 1.60e-02 | 0.3690 | 0.192000 | 0.231000 | -0.214000 | 3.77e-02 | 1.27e-02 | 2.08e-02 |
| Long-term potentiation | 14 | 1.79e-01 | 2.40e-01 | 0.3680 | -0.130000 | -0.246000 | -0.242000 | 4.00e-01 | 1.11e-01 | 1.17e-01 |
| Degradation of cysteine and homocysteine | 12 | 2.50e-01 | 3.13e-01 | 0.3680 | 0.153000 | 0.125000 | -0.310000 | 3.58e-01 | 4.52e-01 | 6.29e-02 |
| Intra-Golgi and retrograde Golgi-to-ER traffic | 179 | 4.80e-09 | 5.78e-08 | 0.3680 | 0.268000 | 0.233000 | -0.093800 | 5.92e-10 | 7.32e-08 | 3.04e-02 |
| SCF-beta-TrCP mediated degradation of Emi1 | 53 | 2.05e-05 | 1.01e-04 | 0.3670 | 0.302000 | 0.088500 | -0.189000 | 1.41e-04 | 2.65e-01 | 1.72e-02 |
| SHC1 events in ERBB2 signaling | 17 | 1.55e-01 | 2.13e-01 | 0.3670 | 0.279000 | 0.155000 | -0.182000 | 4.67e-02 | 2.70e-01 | 1.93e-01 |
| Retinoid metabolism and transport | 24 | 8.18e-02 | 1.25e-01 | 0.3670 | 0.209000 | 0.229000 | -0.196000 | 7.57e-02 | 5.25e-02 | 9.65e-02 |
| Collagen formation | 64 | 9.10e-05 | 3.77e-04 | 0.3670 | 0.162000 | 0.162000 | -0.287000 | 2.53e-02 | 2.54e-02 | 7.29e-05 |
| Potential therapeutics for SARS | 36 | 3.43e-02 | 6.00e-02 | 0.3660 | 0.259000 | 0.219000 | -0.138000 | 7.20e-03 | 2.32e-02 | 1.53e-01 |
| Macroautophagy | 110 | 6.96e-08 | 7.00e-07 | 0.3650 | 0.271000 | 0.131000 | -0.205000 | 8.72e-07 | 1.72e-02 | 2.00e-04 |
| RNA Polymerase I Transcription Termination | 30 | 3.52e-03 | 8.68e-03 | 0.3640 | -0.141000 | -0.335000 | 0.004240 | 1.80e-01 | 1.47e-03 | 9.68e-01 |
| Negative regulation of FGFR2 signaling | 23 | 5.58e-02 | 9.15e-02 | 0.3640 | 0.213000 | 0.101000 | -0.277000 | 7.73e-02 | 4.00e-01 | 2.14e-02 |
| cGMP effects | 13 | 2.02e-01 | 2.63e-01 | 0.3640 | 0.296000 | 0.134000 | -0.164000 | 6.51e-02 | 4.04e-01 | 3.06e-01 |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | 33 | 1.52e-02 | 3.02e-02 | 0.3630 | 0.185000 | 0.260000 | -0.174000 | 6.54e-02 | 9.86e-03 | 8.37e-02 |
| Sphingolipid metabolism | 77 | 2.79e-04 | 9.87e-04 | 0.3630 | 0.232000 | 0.228000 | -0.162000 | 4.29e-04 | 5.46e-04 | 1.42e-02 |
| Defects in vitamin and cofactor metabolism | 21 | 1.96e-01 | 2.57e-01 | 0.3630 | -0.255000 | -0.248000 | 0.071800 | 4.27e-02 | 4.94e-02 | 5.69e-01 |
| UCH proteinases | 86 | 1.47e-05 | 7.69e-05 | 0.3630 | 0.234000 | 0.144000 | -0.238000 | 1.81e-04 | 2.14e-02 | 1.36e-04 |
| Asymmetric localization of PCP proteins | 60 | 1.55e-04 | 5.96e-04 | 0.3630 | 0.259000 | 0.116000 | -0.225000 | 5.14e-04 | 1.21e-01 | 2.53e-03 |
| Hedgehog 'on' state | 75 | 6.49e-05 | 2.81e-04 | 0.3610 | 0.267000 | 0.151000 | -0.190000 | 6.36e-05 | 2.38e-02 | 4.39e-03 |
| Aggrephagy | 22 | 1.44e-02 | 2.91e-02 | 0.3610 | 0.244000 | 0.023100 | -0.265000 | 4.77e-02 | 8.51e-01 | 3.16e-02 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 53 | 2.28e-03 | 6.06e-03 | 0.3600 | 0.255000 | 0.163000 | -0.195000 | 1.30e-03 | 4.02e-02 | 1.38e-02 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | 53 | 2.28e-03 | 6.06e-03 | 0.3600 | 0.255000 | 0.163000 | -0.195000 | 1.30e-03 | 4.02e-02 | 1.38e-02 |
| Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 53 | 2.28e-03 | 6.06e-03 | 0.3600 | 0.255000 | 0.163000 | -0.195000 | 1.30e-03 | 4.02e-02 | 1.38e-02 |
| Signaling by NOTCH1 PEST Domain Mutants in Cancer | 53 | 2.28e-03 | 6.06e-03 | 0.3600 | 0.255000 | 0.163000 | -0.195000 | 1.30e-03 | 4.02e-02 | 1.38e-02 |
| Signaling by NOTCH1 in Cancer | 53 | 2.28e-03 | 6.06e-03 | 0.3600 | 0.255000 | 0.163000 | -0.195000 | 1.30e-03 | 4.02e-02 | 1.38e-02 |
| Regulation of insulin secretion | 60 | 3.15e-03 | 7.93e-03 | 0.3600 | 0.253000 | 0.221000 | -0.130000 | 7.09e-04 | 3.03e-03 | 8.08e-02 |
| GRB2 events in ERBB2 signaling | 11 | 8.76e-02 | 1.33e-01 | 0.3600 | 0.244000 | -0.024000 | -0.264000 | 1.61e-01 | 8.90e-01 | 1.30e-01 |
| Trafficking and processing of endosomal TLR | 13 | 2.94e-01 | 3.59e-01 | 0.3600 | 0.301000 | 0.196000 | -0.022500 | 6.00e-02 | 2.21e-01 | 8.88e-01 |
| Ephrin signaling | 17 | 1.21e-01 | 1.75e-01 | 0.3600 | 0.157000 | 0.064800 | -0.317000 | 2.63e-01 | 6.44e-01 | 2.35e-02 |
| Signaling by NODAL | 13 | 1.42e-01 | 1.98e-01 | 0.3600 | -0.048400 | -0.044800 | -0.354000 | 7.63e-01 | 7.80e-01 | 2.73e-02 |
| FCGR activation | 76 | 3.14e-06 | 2.02e-05 | 0.3590 | -0.144000 | -0.227000 | 0.238000 | 2.98e-02 | 6.21e-04 | 3.42e-04 |
| Scavenging of heme from plasma | 71 | 9.37e-09 | 1.07e-07 | 0.3590 | -0.069700 | -0.231000 | 0.265000 | 3.10e-01 | 7.64e-04 | 1.11e-04 |
| Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 27 | 1.01e-02 | 2.16e-02 | 0.3580 | 0.058200 | -0.099200 | -0.339000 | 6.01e-01 | 3.72e-01 | 2.32e-03 |
| Translation of structural proteins | 28 | 2.50e-02 | 4.64e-02 | 0.3580 | 0.138000 | 0.129000 | -0.304000 | 2.06e-01 | 2.38e-01 | 5.43e-03 |
| Prostacyclin signalling through prostacyclin receptor | 16 | 2.80e-01 | 3.46e-01 | 0.3560 | 0.262000 | 0.196000 | -0.141000 | 6.95e-02 | 1.75e-01 | 3.29e-01 |
| HDR through Homologous Recombination (HRR) | 66 | 1.58e-03 | 4.43e-03 | 0.3560 | -0.232000 | -0.227000 | 0.146000 | 1.10e-03 | 1.45e-03 | 3.97e-02 |
| Mitochondrial calcium ion transport | 22 | 3.30e-03 | 8.23e-03 | 0.3560 | 0.100000 | -0.175000 | -0.293000 | 4.15e-01 | 1.56e-01 | 1.73e-02 |
| Metabolism of fat-soluble vitamins | 28 | 5.88e-02 | 9.58e-02 | 0.3560 | 0.207000 | 0.176000 | -0.229000 | 5.82e-02 | 1.07e-01 | 3.56e-02 |
| Incretin synthesis, secretion, and inactivation | 10 | 8.95e-02 | 1.35e-01 | 0.3550 | 0.163000 | 0.005450 | 0.316000 | 3.73e-01 | 9.76e-01 | 8.35e-02 |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 10 | 8.95e-02 | 1.35e-01 | 0.3550 | 0.163000 | 0.005450 | 0.316000 | 3.73e-01 | 9.76e-01 | 8.35e-02 |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 16 | 3.31e-01 | 3.99e-01 | 0.3550 | 0.246000 | 0.250000 | -0.055400 | 8.85e-02 | 8.29e-02 | 7.01e-01 |
| Keratinization | 32 | 2.18e-02 | 4.12e-02 | 0.3550 | 0.261000 | 0.133000 | -0.200000 | 1.07e-02 | 1.92e-01 | 4.97e-02 |
| Norepinephrine Neurotransmitter Release Cycle | 13 | 1.77e-01 | 2.38e-01 | 0.3540 | -0.033800 | -0.071000 | -0.346000 | 8.33e-01 | 6.58e-01 | 3.10e-02 |
| Vesicle-mediated transport | 646 | 4.10e-30 | 1.36e-28 | 0.3540 | 0.268000 | 0.218000 | -0.077300 | 2.66e-31 | 2.55e-21 | 8.02e-04 |
| HSF1-dependent transactivation | 29 | 1.35e-02 | 2.75e-02 | 0.3540 | 0.123000 | 0.000191 | -0.332000 | 2.51e-01 | 9.99e-01 | 1.98e-03 |
| Formation of tubulin folding intermediates by CCT/TriC | 22 | 5.52e-03 | 1.27e-02 | 0.3540 | 0.289000 | 0.024100 | -0.203000 | 1.91e-02 | 8.45e-01 | 9.95e-02 |
| Dectin-2 family | 19 | 7.68e-02 | 1.20e-01 | 0.3530 | 0.161000 | 0.293000 | -0.115000 | 2.25e-01 | 2.72e-02 | 3.87e-01 |
| Synthesis of IP3 and IP4 in the cytosol | 22 | 3.22e-02 | 5.69e-02 | 0.3530 | 0.091300 | 0.148000 | -0.307000 | 4.59e-01 | 2.28e-01 | 1.28e-02 |
| SIRT1 negatively regulates rRNA expression | 24 | 3.20e-02 | 5.67e-02 | 0.3530 | 0.279000 | 0.103000 | -0.189000 | 1.80e-02 | 3.80e-01 | 1.08e-01 |
| Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | 14 | 3.73e-01 | 4.41e-01 | 0.3520 | 0.224000 | 0.272000 | 0.004540 | 1.46e-01 | 7.82e-02 | 9.77e-01 |
| E2F mediated regulation of DNA replication | 22 | 3.31e-02 | 5.81e-02 | 0.3520 | -0.120000 | -0.212000 | 0.254000 | 3.28e-01 | 8.51e-02 | 3.89e-02 |
| Attenuation phase | 23 | 1.97e-02 | 3.77e-02 | 0.3520 | 0.208000 | 0.011800 | -0.283000 | 8.35e-02 | 9.22e-01 | 1.86e-02 |
| Chemokine receptors bind chemokines | 37 | 7.81e-03 | 1.71e-02 | 0.3520 | -0.118000 | -0.218000 | -0.249000 | 2.14e-01 | 2.14e-02 | 8.73e-03 |
| Acyl chain remodelling of PC | 19 | 2.35e-01 | 2.97e-01 | 0.3520 | 0.234000 | 0.222000 | -0.141000 | 7.80e-02 | 9.41e-02 | 2.87e-01 |
| Regulation of TP53 Activity through Acetylation | 29 | 1.08e-02 | 2.25e-02 | 0.3510 | -0.198000 | -0.138000 | -0.256000 | 6.55e-02 | 1.98e-01 | 1.72e-02 |
| Degradation of beta-catenin by the destruction complex | 83 | 1.27e-05 | 6.73e-05 | 0.3510 | 0.261000 | 0.126000 | -0.199000 | 3.98e-05 | 4.80e-02 | 1.71e-03 |
| Intra-Golgi traffic | 43 | 2.40e-02 | 4.47e-02 | 0.3510 | 0.227000 | 0.259000 | -0.066900 | 1.00e-02 | 3.26e-03 | 4.48e-01 |
| Collagen biosynthesis and modifying enzymes | 46 | 1.31e-03 | 3.78e-03 | 0.3500 | 0.107000 | 0.094600 | -0.320000 | 2.08e-01 | 2.67e-01 | 1.74e-04 |
| Translesion Synthesis by POLH | 18 | 9.62e-02 | 1.44e-01 | 0.3500 | -0.126000 | -0.286000 | -0.159000 | 3.55e-01 | 3.59e-02 | 2.44e-01 |
| Defective B4GALT7 causes EDS, progeroid type | 11 | 2.71e-01 | 3.36e-01 | 0.3500 | -0.044600 | -0.140000 | -0.318000 | 7.98e-01 | 4.23e-01 | 6.78e-02 |
| Metabolism of RNA | 685 | 1.76e-61 | 1.26e-59 | 0.3490 | -0.088600 | -0.289000 | -0.175000 | 7.79e-05 | 3.79e-38 | 5.10e-15 |
| RIP-mediated NFkB activation via ZBP1 | 17 | 2.20e-01 | 2.81e-01 | 0.3490 | 0.195000 | 0.236000 | -0.167000 | 1.63e-01 | 9.18e-02 | 2.33e-01 |
| Signaling by FGFR3 | 31 | 5.12e-02 | 8.51e-02 | 0.3480 | 0.273000 | 0.176000 | -0.126000 | 8.56e-03 | 8.97e-02 | 2.25e-01 |
| SUMOylation of intracellular receptors | 25 | 1.12e-01 | 1.63e-01 | 0.3480 | 0.218000 | 0.188000 | -0.195000 | 5.90e-02 | 1.04e-01 | 9.07e-02 |
| Signaling by cytosolic FGFR1 fusion mutants | 18 | 2.41e-01 | 3.02e-01 | 0.3480 | 0.244000 | 0.229000 | 0.094000 | 7.25e-02 | 9.24e-02 | 4.90e-01 |
| Caspase activation via Death Receptors in the presence of ligand | 16 | 2.28e-01 | 2.89e-01 | 0.3480 | 0.259000 | 0.204000 | 0.111000 | 7.27e-02 | 1.59e-01 | 4.40e-01 |
| Glutamate binding, activation of AMPA receptors and synaptic plasticity | 20 | 1.11e-01 | 1.62e-01 | 0.3480 | 0.163000 | 0.209000 | -0.225000 | 2.06e-01 | 1.06e-01 | 8.20e-02 |
| Trafficking of AMPA receptors | 20 | 1.11e-01 | 1.62e-01 | 0.3480 | 0.163000 | 0.209000 | -0.225000 | 2.06e-01 | 1.06e-01 | 8.20e-02 |
| Synaptic adhesion-like molecules | 14 | 1.04e-01 | 1.53e-01 | 0.3480 | 0.070000 | 0.159000 | -0.301000 | 6.50e-01 | 3.03e-01 | 5.11e-02 |
| RET signaling | 32 | 4.56e-02 | 7.64e-02 | 0.3470 | 0.198000 | 0.235000 | -0.161000 | 5.27e-02 | 2.15e-02 | 1.14e-01 |
| DAP12 interactions | 39 | 1.89e-02 | 3.64e-02 | 0.3470 | 0.194000 | 0.213000 | -0.193000 | 3.65e-02 | 2.11e-02 | 3.70e-02 |
| Regulation of mRNA stability by proteins that bind AU-rich elements | 87 | 7.90e-08 | 7.73e-07 | 0.3470 | 0.293000 | 0.090600 | -0.161000 | 2.22e-06 | 1.44e-01 | 9.66e-03 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 51 | 4.15e-03 | 1.00e-02 | 0.3460 | 0.288000 | 0.184000 | -0.051700 | 3.72e-04 | 2.30e-02 | 5.23e-01 |
| Metabolism of carbohydrates | 241 | 4.16e-15 | 8.85e-14 | 0.3450 | 0.154000 | 0.134000 | -0.279000 | 3.85e-05 | 3.46e-04 | 8.80e-14 |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 12 | 1.54e-01 | 2.12e-01 | 0.3430 | 0.275000 | 0.132000 | 0.157000 | 9.85e-02 | 4.30e-01 | 3.45e-01 |
| Regulation of PTEN gene transcription | 59 | 4.65e-04 | 1.54e-03 | 0.3430 | 0.171000 | 0.075800 | -0.288000 | 2.31e-02 | 3.14e-01 | 1.30e-04 |
| Nuclear Pore Complex (NPC) Disassembly | 36 | 2.46e-02 | 4.56e-02 | 0.3430 | -0.186000 | -0.237000 | 0.164000 | 5.32e-02 | 1.38e-02 | 8.85e-02 |
| Autodegradation of Cdh1 by Cdh1:APC/C | 64 | 6.55e-06 | 3.87e-05 | 0.3430 | 0.276000 | 0.068400 | -0.192000 | 1.35e-04 | 3.44e-01 | 7.97e-03 |
| Stabilization of p53 | 54 | 1.27e-04 | 4.99e-04 | 0.3430 | 0.284000 | 0.094400 | -0.167000 | 3.01e-04 | 2.30e-01 | 3.43e-02 |
| Receptor Mediated Mitophagy | 11 | 2.64e-01 | 3.27e-01 | 0.3420 | 0.289000 | 0.110000 | -0.147000 | 9.70e-02 | 5.29e-01 | 3.97e-01 |
| Apoptotic factor-mediated response | 18 | 7.36e-02 | 1.15e-01 | 0.3420 | 0.312000 | 0.141000 | -0.000791 | 2.19e-02 | 3.01e-01 | 9.95e-01 |
| Signaling by FGFR4 | 31 | 3.60e-02 | 6.28e-02 | 0.3420 | 0.258000 | 0.136000 | -0.179000 | 1.30e-02 | 1.89e-01 | 8.47e-02 |
| TNFR1-induced proapoptotic signaling | 12 | 1.47e-01 | 2.03e-01 | 0.3420 | -0.316000 | -0.126000 | -0.032700 | 5.80e-02 | 4.49e-01 | 8.45e-01 |
| Interleukin-4 and Interleukin-13 signaling | 90 | 4.89e-06 | 3.03e-05 | 0.3410 | 0.285000 | 0.138000 | -0.127000 | 2.91e-06 | 2.34e-02 | 3.80e-02 |
| Signaling by Hippo | 18 | 2.50e-01 | 3.13e-01 | 0.3410 | 0.235000 | 0.223000 | 0.105000 | 8.42e-02 | 1.01e-01 | 4.39e-01 |
| C-type lectin receptors (CLRs) | 128 | 1.59e-07 | 1.46e-06 | 0.3400 | 0.265000 | 0.143000 | -0.158000 | 2.31e-07 | 5.18e-03 | 1.98e-03 |
| Dual Incision in GG-NER | 41 | 7.56e-03 | 1.66e-02 | 0.3390 | -0.165000 | -0.295000 | -0.025400 | 6.73e-02 | 1.06e-03 | 7.78e-01 |
| Apoptosis | 166 | 2.96e-09 | 3.66e-08 | 0.3390 | 0.279000 | 0.165000 | -0.102000 | 5.85e-10 | 2.49e-04 | 2.33e-02 |
| Formation of the beta-catenin:TCF transactivating complex | 46 | 8.81e-03 | 1.91e-02 | 0.3390 | 0.212000 | 0.137000 | -0.227000 | 1.30e-02 | 1.08e-01 | 7.82e-03 |
| Beta-catenin independent WNT signaling | 136 | 3.82e-07 | 3.29e-06 | 0.3390 | 0.232000 | 0.152000 | -0.194000 | 3.06e-06 | 2.17e-03 | 8.98e-05 |
| Repression of WNT target genes | 14 | 1.60e-01 | 2.18e-01 | 0.3380 | -0.149000 | -0.108000 | -0.284000 | 3.35e-01 | 4.83e-01 | 6.60e-02 |
| Resolution of D-loop Structures through Holliday Junction Intermediates | 32 | 2.92e-02 | 5.24e-02 | 0.3370 | -0.175000 | -0.090900 | 0.273000 | 8.63e-02 | 3.74e-01 | 7.48e-03 |
| Metalloprotease DUBs | 21 | 2.13e-01 | 2.74e-01 | 0.3370 | 0.267000 | 0.200000 | -0.047100 | 3.43e-02 | 1.12e-01 | 7.09e-01 |
| FGFR2 alternative splicing | 25 | 1.39e-02 | 2.81e-02 | 0.3370 | 0.061700 | -0.130000 | -0.304000 | 5.93e-01 | 2.59e-01 | 8.41e-03 |
| Antiviral mechanism by IFN-stimulated genes | 80 | 1.19e-04 | 4.80e-04 | 0.3360 | -0.185000 | -0.125000 | 0.252000 | 4.23e-03 | 5.39e-02 | 9.78e-05 |
| ZBP1(DAI) mediated induction of type I IFNs | 20 | 1.92e-01 | 2.53e-01 | 0.3350 | 0.190000 | 0.226000 | -0.159000 | 1.42e-01 | 7.98e-02 | 2.17e-01 |
| Programmed Cell Death | 169 | 4.39e-09 | 5.33e-08 | 0.3350 | 0.276000 | 0.167000 | -0.090700 | 5.75e-10 | 1.80e-04 | 4.18e-02 |
| N-Glycan antennae elongation | 13 | 7.81e-02 | 1.21e-01 | 0.3340 | -0.096000 | 0.021400 | -0.319000 | 5.49e-01 | 8.94e-01 | 4.62e-02 |
| p75 NTR receptor-mediated signalling | 88 | 1.04e-04 | 4.23e-04 | 0.3340 | 0.197000 | 0.147000 | -0.225000 | 1.40e-03 | 1.69e-02 | 2.59e-04 |
| Sialic acid metabolism | 28 | 1.16e-01 | 1.67e-01 | 0.3320 | 0.210000 | 0.196000 | -0.166000 | 5.43e-02 | 7.19e-02 | 1.28e-01 |
| Constitutive Signaling by EGFRvIII | 14 | 2.37e-01 | 2.98e-01 | 0.3320 | 0.288000 | 0.163000 | 0.032700 | 6.23e-02 | 2.92e-01 | 8.32e-01 |
| Signaling by EGFRvIII in Cancer | 14 | 2.37e-01 | 2.98e-01 | 0.3320 | 0.288000 | 0.163000 | 0.032700 | 6.23e-02 | 2.92e-01 | 8.32e-01 |
| mitochondrial fatty acid beta-oxidation of saturated fatty acids | 11 | 1.80e-01 | 2.41e-01 | 0.3310 | 0.163000 | -0.052100 | -0.284000 | 3.50e-01 | 7.65e-01 | 1.03e-01 |
| SUMOylation of ubiquitinylation proteins | 39 | 2.44e-02 | 4.54e-02 | 0.3310 | -0.178000 | -0.193000 | 0.202000 | 5.46e-02 | 3.69e-02 | 2.90e-02 |
| HSF1 activation | 26 | 1.08e-02 | 2.25e-02 | 0.3300 | 0.092600 | -0.110000 | -0.297000 | 4.14e-01 | 3.32e-01 | 8.72e-03 |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 18 | 7.75e-02 | 1.20e-01 | 0.3290 | 0.279000 | 0.083400 | -0.152000 | 4.02e-02 | 5.40e-01 | 2.63e-01 |
| Signaling by Ligand-Responsive EGFR Variants in Cancer | 18 | 7.75e-02 | 1.20e-01 | 0.3290 | 0.279000 | 0.083400 | -0.152000 | 4.02e-02 | 5.40e-01 | 2.63e-01 |
| NGF-stimulated transcription | 31 | 6.60e-02 | 1.06e-01 | 0.3290 | 0.247000 | 0.151000 | -0.156000 | 1.73e-02 | 1.46e-01 | 1.32e-01 |
| O-glycosylation of TSR domain-containing proteins | 26 | 2.17e-02 | 4.11e-02 | 0.3290 | -0.289000 | -0.138000 | -0.073800 | 1.07e-02 | 2.23e-01 | 5.15e-01 |
| Initiation of Nuclear Envelope (NE) Reformation | 19 | 2.87e-01 | 3.53e-01 | 0.3280 | 0.255000 | 0.206000 | -0.003510 | 5.41e-02 | 1.20e-01 | 9.79e-01 |
| MAPK6/MAPK4 signaling | 81 | 5.73e-06 | 3.45e-05 | 0.3280 | 0.280000 | 0.106000 | -0.135000 | 1.36e-05 | 9.81e-02 | 3.59e-02 |
| Processing of SMDT1 | 15 | 5.22e-02 | 8.65e-02 | 0.3280 | 0.048900 | -0.198000 | -0.257000 | 7.43e-01 | 1.84e-01 | 8.54e-02 |
| Regulation of KIT signaling | 15 | 1.74e-01 | 2.35e-01 | 0.3270 | 0.097800 | 0.149000 | -0.275000 | 5.12e-01 | 3.18e-01 | 6.54e-02 |
| Apoptotic execution phase | 45 | 4.11e-02 | 7.00e-02 | 0.3270 | 0.242000 | 0.220000 | -0.015800 | 4.98e-03 | 1.08e-02 | 8.54e-01 |
| Metabolism of amino acids and derivatives | 322 | 1.74e-30 | 5.92e-29 | 0.3270 | -0.004800 | -0.222000 | -0.240000 | 8.82e-01 | 6.99e-12 | 1.32e-13 |
| RAF-independent MAPK1/3 activation | 21 | 1.30e-01 | 1.84e-01 | 0.3270 | 0.145000 | 0.089000 | -0.279000 | 2.49e-01 | 4.80e-01 | 2.68e-02 |
| Costimulation by the CD28 family | 74 | 8.29e-04 | 2.51e-03 | 0.3260 | -0.224000 | -0.202000 | -0.126000 | 8.81e-04 | 2.66e-03 | 6.17e-02 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 12 | 1.23e-01 | 1.77e-01 | 0.3260 | 0.041700 | 0.279000 | 0.164000 | 8.03e-01 | 9.46e-02 | 3.24e-01 |
| Nuclear Receptor transcription pathway | 36 | 6.71e-03 | 1.50e-02 | 0.3260 | 0.006860 | 0.006080 | -0.326000 | 9.43e-01 | 9.50e-01 | 7.18e-04 |
| APC/C:Cdc20 mediated degradation of Securin | 66 | 1.82e-05 | 9.26e-05 | 0.3250 | 0.269000 | 0.073700 | -0.166000 | 1.54e-04 | 3.01e-01 | 1.94e-02 |
| RHO GTPase Effectors | 249 | 6.71e-10 | 8.77e-09 | 0.3250 | 0.242000 | 0.202000 | -0.079000 | 4.79e-11 | 3.97e-08 | 3.19e-02 |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 12 | 1.96e-01 | 2.57e-01 | 0.3250 | 0.177000 | -0.016400 | -0.272000 | 2.89e-01 | 9.21e-01 | 1.03e-01 |
| Glycerophospholipid biosynthesis | 106 | 1.20e-04 | 4.80e-04 | 0.3250 | 0.234000 | 0.181000 | -0.132000 | 3.07e-05 | 1.25e-03 | 1.86e-02 |
| Negative regulation of NMDA receptor-mediated neuronal transmission | 14 | 2.06e-01 | 2.66e-01 | 0.3240 | -0.193000 | -0.132000 | -0.224000 | 2.11e-01 | 3.91e-01 | 1.46e-01 |
| Elastic fibre formation | 32 | 8.34e-02 | 1.28e-01 | 0.3240 | 0.200000 | 0.179000 | -0.181000 | 4.99e-02 | 7.92e-02 | 7.59e-02 |
| Defects in cobalamin (B12) metabolism | 13 | 3.58e-01 | 4.26e-01 | 0.3230 | -0.165000 | -0.222000 | 0.168000 | 3.04e-01 | 1.66e-01 | 2.95e-01 |
| Hemostasis | 544 | 2.47e-24 | 6.86e-23 | 0.3230 | 0.244000 | 0.161000 | -0.137000 | 1.82e-22 | 1.34e-10 | 4.66e-08 |
| Signaling by ERBB4 | 44 | 8.44e-03 | 1.84e-02 | 0.3230 | 0.247000 | 0.115000 | -0.172000 | 4.51e-03 | 1.85e-01 | 4.80e-02 |
| TNFs bind their physiological receptors | 25 | 2.31e-02 | 4.31e-02 | 0.3230 | -0.082000 | -0.277000 | -0.145000 | 4.78e-01 | 1.67e-02 | 2.10e-01 |
| Chaperonin-mediated protein folding | 84 | 3.44e-04 | 1.19e-03 | 0.3230 | 0.229000 | 0.144000 | -0.176000 | 2.89e-04 | 2.22e-02 | 5.39e-03 |
| RIPK1-mediated regulated necrosis | 16 | 1.31e-01 | 1.85e-01 | 0.3220 | 0.070300 | 0.045700 | 0.311000 | 6.26e-01 | 7.51e-01 | 3.12e-02 |
| Regulated Necrosis | 16 | 1.31e-01 | 1.85e-01 | 0.3220 | 0.070300 | 0.045700 | 0.311000 | 6.26e-01 | 7.51e-01 | 3.12e-02 |
| Diseases of signal transduction by growth factor receptors and second messengers | 340 | 9.13e-15 | 1.91e-13 | 0.3220 | 0.231000 | 0.164000 | -0.153000 | 2.53e-13 | 2.09e-07 | 1.26e-06 |
| Metabolism of nitric oxide: NOS3 activation and regulation | 12 | 1.75e-01 | 2.36e-01 | 0.3210 | 0.274000 | 0.058700 | -0.157000 | 1.01e-01 | 7.25e-01 | 3.45e-01 |
| TICAM1,TRAF6-dependent induction of TAK1 complex | 11 | 2.19e-01 | 2.80e-01 | 0.3210 | 0.279000 | 0.068700 | -0.143000 | 1.09e-01 | 6.93e-01 | 4.11e-01 |
| SUMOylation of RNA binding proteins | 47 | 1.68e-02 | 3.28e-02 | 0.3200 | -0.181000 | -0.261000 | 0.038700 | 3.17e-02 | 1.93e-03 | 6.46e-01 |
| ESR-mediated signaling | 160 | 6.67e-09 | 7.82e-08 | 0.3190 | 0.238000 | 0.112000 | -0.182000 | 2.13e-07 | 1.49e-02 | 7.05e-05 |
| Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | 36 | 3.20e-02 | 5.67e-02 | 0.3190 | 0.267000 | 0.147000 | -0.096400 | 5.59e-03 | 1.28e-01 | 3.17e-01 |
| Regulation of RAS by GAPs | 66 | 8.59e-04 | 2.58e-03 | 0.3190 | 0.252000 | 0.126000 | -0.151000 | 4.06e-04 | 7.63e-02 | 3.44e-02 |
| Resolution of D-Loop Structures | 33 | 3.22e-02 | 5.69e-02 | 0.3190 | -0.178000 | -0.070800 | 0.255000 | 7.61e-02 | 4.81e-01 | 1.12e-02 |
| RMTs methylate histone arginines | 37 | 1.06e-02 | 2.23e-02 | 0.3190 | 0.006530 | -0.044000 | -0.316000 | 9.45e-01 | 6.44e-01 | 8.83e-04 |
| Arachidonic acid metabolism | 43 | 3.23e-02 | 5.69e-02 | 0.3190 | 0.191000 | 0.181000 | -0.180000 | 3.04e-02 | 3.97e-02 | 4.12e-02 |
| TCF dependent signaling in response to WNT | 165 | 8.95e-08 | 8.70e-07 | 0.3190 | 0.213000 | 0.138000 | -0.193000 | 2.30e-06 | 2.20e-03 | 1.94e-05 |
| Elevation of cytosolic Ca2+ levels | 12 | 3.61e-01 | 4.28e-01 | 0.3170 | 0.119000 | 0.118000 | -0.270000 | 4.76e-01 | 4.80e-01 | 1.06e-01 |
| Signaling by WNT | 253 | 5.44e-11 | 7.79e-10 | 0.3170 | 0.216000 | 0.154000 | -0.173000 | 3.09e-09 | 2.34e-05 | 2.18e-06 |
| COPI-dependent Golgi-to-ER retrograde traffic | 78 | 4.27e-03 | 1.02e-02 | 0.3170 | 0.229000 | 0.215000 | -0.037600 | 4.61e-04 | 1.02e-03 | 5.66e-01 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | 72 | 5.31e-05 | 2.36e-04 | 0.3160 | 0.265000 | 0.096600 | -0.144000 | 1.04e-04 | 1.56e-01 | 3.47e-02 |
| PTEN Regulation | 138 | 1.10e-06 | 8.17e-06 | 0.3160 | 0.219000 | 0.129000 | -0.188000 | 9.05e-06 | 8.94e-03 | 1.35e-04 |
| MASTL Facilitates Mitotic Progression | 10 | 2.29e-01 | 2.91e-01 | 0.3160 | 0.289000 | 0.105000 | 0.074000 | 1.14e-01 | 5.66e-01 | 6.85e-01 |
| Activation of kainate receptors upon glutamate binding | 26 | 1.30e-01 | 1.84e-01 | 0.3160 | 0.180000 | 0.139000 | -0.219000 | 1.11e-01 | 2.20e-01 | 5.35e-02 |
| Synthesis of PE | 12 | 3.67e-01 | 4.34e-01 | 0.3160 | -0.182000 | -0.069500 | 0.249000 | 2.76e-01 | 6.77e-01 | 1.36e-01 |
| Tie2 Signaling | 16 | 3.42e-01 | 4.11e-01 | 0.3150 | 0.260000 | 0.177000 | -0.014600 | 7.23e-02 | 2.19e-01 | 9.19e-01 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 13 | 2.84e-01 | 3.49e-01 | 0.3150 | 0.129000 | 0.215000 | -0.190000 | 4.21e-01 | 1.80e-01 | 2.35e-01 |
| Selective autophagy | 58 | 1.53e-05 | 7.96e-05 | 0.3140 | 0.219000 | -0.006810 | -0.225000 | 3.98e-03 | 9.29e-01 | 2.99e-03 |
| Axon guidance | 453 | 4.68e-28 | 1.45e-26 | 0.3130 | 0.120000 | 0.001290 | -0.289000 | 1.17e-05 | 9.62e-01 | 4.21e-26 |
| MicroRNA (miRNA) biogenesis | 24 | 5.87e-02 | 9.58e-02 | 0.3130 | 0.067600 | -0.058600 | -0.300000 | 5.66e-01 | 6.19e-01 | 1.09e-02 |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 10 | 3.95e-01 | 4.60e-01 | 0.3130 | 0.011400 | -0.090800 | -0.299000 | 9.50e-01 | 6.19e-01 | 1.01e-01 |
| Defective EXT2 causes exostoses 2 | 10 | 3.95e-01 | 4.60e-01 | 0.3130 | 0.011400 | -0.090800 | -0.299000 | 9.50e-01 | 6.19e-01 | 1.01e-01 |
| Extracellular matrix organization | 216 | 7.13e-10 | 9.23e-09 | 0.3130 | 0.183000 | 0.135000 | -0.215000 | 3.69e-06 | 6.24e-04 | 5.29e-08 |
| Transport of bile salts and organic acids, metal ions and amine compounds | 54 | 3.07e-02 | 5.46e-02 | 0.3130 | 0.221000 | 0.215000 | -0.053000 | 5.00e-03 | 6.31e-03 | 5.01e-01 |
| Striated Muscle Contraction | 23 | 2.57e-01 | 3.20e-01 | 0.3110 | 0.238000 | 0.184000 | -0.078900 | 4.86e-02 | 1.26e-01 | 5.13e-01 |
| Glutamate and glutamine metabolism | 12 | 2.81e-01 | 3.46e-01 | 0.3100 | -0.097700 | -0.267000 | -0.125000 | 5.58e-01 | 1.09e-01 | 4.55e-01 |
| Cellular responses to stress | 499 | 2.54e-35 | 9.60e-34 | 0.3100 | 0.142000 | -0.024100 | -0.275000 | 5.19e-08 | 3.56e-01 | 7.79e-26 |
| Cellular responses to external stimuli | 505 | 3.42e-35 | 1.26e-33 | 0.3100 | 0.146000 | -0.017400 | -0.273000 | 1.77e-08 | 5.04e-01 | 8.38e-26 |
| Carboxyterminal post-translational modifications of tubulin | 26 | 1.35e-01 | 1.90e-01 | 0.3100 | 0.170000 | 0.254000 | -0.048700 | 1.33e-01 | 2.47e-02 | 6.67e-01 |
| Cellular Senescence | 144 | 1.67e-06 | 1.16e-05 | 0.3100 | 0.192000 | 0.132000 | -0.204000 | 7.23e-05 | 6.16e-03 | 2.32e-05 |
| Signaling by NOTCH2 | 30 | 4.89e-02 | 8.14e-02 | 0.3100 | 0.116000 | 0.141000 | -0.250000 | 2.72e-01 | 1.82e-01 | 1.78e-02 |
| Pregnenolone biosynthesis | 10 | 3.91e-01 | 4.57e-01 | 0.3070 | 0.063100 | 0.092700 | -0.286000 | 7.30e-01 | 6.12e-01 | 1.17e-01 |
| Protein folding | 90 | 5.28e-04 | 1.71e-03 | 0.3070 | 0.207000 | 0.141000 | -0.179000 | 7.08e-04 | 2.11e-02 | 3.39e-03 |
| NOTCH2 intracellular domain regulates transcription | 11 | 4.23e-01 | 4.86e-01 | 0.3070 | 0.146000 | 0.267000 | -0.038200 | 4.00e-01 | 1.26e-01 | 8.27e-01 |
| FGFR2 mutant receptor activation | 22 | 4.03e-02 | 6.89e-02 | 0.3060 | 0.021400 | -0.172000 | -0.253000 | 8.62e-01 | 1.62e-01 | 4.02e-02 |
| Purine catabolism | 16 | 1.23e-01 | 1.77e-01 | 0.3060 | 0.086900 | -0.094500 | -0.278000 | 5.47e-01 | 5.13e-01 | 5.40e-02 |
| MHC class II antigen presentation | 101 | 7.03e-04 | 2.18e-03 | 0.3060 | 0.207000 | 0.190000 | -0.122000 | 3.22e-04 | 9.92e-04 | 3.41e-02 |
| RA biosynthesis pathway | 13 | 3.18e-01 | 3.84e-01 | 0.3060 | -0.231000 | -0.147000 | -0.137000 | 1.50e-01 | 3.58e-01 | 3.92e-01 |
| Extra-nuclear estrogen signaling | 66 | 1.96e-03 | 5.32e-03 | 0.3060 | 0.234000 | 0.120000 | -0.155000 | 9.85e-04 | 9.12e-02 | 2.99e-02 |
| Downstream signaling events of B Cell Receptor (BCR) | 79 | 2.83e-05 | 1.34e-04 | 0.3050 | 0.243000 | 0.075700 | -0.168000 | 1.84e-04 | 2.45e-01 | 9.67e-03 |
| Signalling to RAS | 18 | 2.01e-01 | 2.62e-01 | 0.3040 | 0.269000 | 0.137000 | -0.036300 | 4.79e-02 | 3.14e-01 | 7.90e-01 |
| Signaling by Nuclear Receptors | 216 | 3.24e-10 | 4.37e-09 | 0.3040 | 0.210000 | 0.108000 | -0.191000 | 9.91e-08 | 6.21e-03 | 1.35e-06 |
| Signaling by Activin | 10 | 5.06e-01 | 5.66e-01 | 0.3040 | -0.140000 | -0.159000 | -0.217000 | 4.42e-01 | 3.83e-01 | 2.34e-01 |
| Keratan sulfate/keratin metabolism | 27 | 8.37e-02 | 1.28e-01 | 0.3040 | 0.116000 | 0.129000 | -0.249000 | 2.97e-01 | 2.44e-01 | 2.52e-02 |
| Activation of HOX genes during differentiation | 68 | 4.96e-03 | 1.16e-02 | 0.3030 | 0.199000 | 0.141000 | -0.179000 | 4.46e-03 | 4.49e-02 | 1.06e-02 |
| Activation of anterior HOX genes in hindbrain development during early embryogenesis | 68 | 4.96e-03 | 1.16e-02 | 0.3030 | 0.199000 | 0.141000 | -0.179000 | 4.46e-03 | 4.49e-02 | 1.06e-02 |
| G1/S-Specific Transcription | 29 | 7.45e-03 | 1.64e-02 | 0.3020 | -0.084800 | -0.264000 | 0.120000 | 4.29e-01 | 1.39e-02 | 2.65e-01 |
| Nervous system development | 472 | 1.11e-26 | 3.35e-25 | 0.3020 | 0.114000 | 0.005640 | -0.279000 | 2.22e-05 | 8.34e-01 | 2.18e-25 |
| PRC2 methylates histones and DNA | 29 | 7.86e-02 | 1.21e-01 | 0.3010 | 0.191000 | 0.081000 | -0.219000 | 7.46e-02 | 4.50e-01 | 4.17e-02 |
| TP53 Regulates Metabolic Genes | 84 | 2.61e-04 | 9.28e-04 | 0.3010 | 0.235000 | 0.114000 | -0.151000 | 2.01e-04 | 7.09e-02 | 1.67e-02 |
| Constitutive Signaling by Overexpressed ERBB2 | 11 | 5.32e-01 | 5.89e-01 | 0.3010 | 0.246000 | 0.172000 | 0.030600 | 1.58e-01 | 3.24e-01 | 8.61e-01 |
| Maturation of nucleoprotein | 10 | 2.36e-01 | 2.98e-01 | 0.3010 | -0.169000 | 0.056300 | 0.242000 | 3.53e-01 | 7.58e-01 | 1.85e-01 |
| Intracellular signaling by second messengers | 271 | 3.03e-11 | 4.79e-10 | 0.3000 | 0.184000 | 0.130000 | -0.199000 | 1.93e-07 | 2.39e-04 | 1.71e-08 |
| PIP3 activates AKT signaling | 239 | 7.41e-10 | 9.50e-09 | 0.2990 | 0.192000 | 0.129000 | -0.191000 | 3.34e-07 | 6.21e-04 | 3.86e-07 |
| ABC-family proteins mediated transport | 93 | 1.99e-05 | 9.88e-05 | 0.2990 | 0.232000 | 0.084200 | -0.169000 | 1.08e-04 | 1.60e-01 | 4.91e-03 |
| Regulation of necroptotic cell death | 14 | 1.87e-01 | 2.48e-01 | 0.2980 | -0.013500 | -0.079800 | 0.287000 | 9.30e-01 | 6.05e-01 | 6.27e-02 |
| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 36 | 1.07e-02 | 2.25e-02 | 0.2980 | 0.250000 | 0.073000 | -0.145000 | 9.34e-03 | 4.49e-01 | 1.33e-01 |
| Mitotic Telophase/Cytokinesis | 13 | 1.63e-01 | 2.22e-01 | 0.2980 | 0.274000 | 0.095800 | 0.069000 | 8.75e-02 | 5.50e-01 | 6.67e-01 |
| Defective B3GALTL causes Peters-plus syndrome (PpS) | 25 | 3.80e-02 | 6.58e-02 | 0.2980 | -0.267000 | -0.114000 | -0.065300 | 2.07e-02 | 3.26e-01 | 5.72e-01 |
| Estrogen-dependent gene expression | 98 | 2.37e-05 | 1.15e-04 | 0.2980 | 0.215000 | 0.080800 | -0.190000 | 2.41e-04 | 1.67e-01 | 1.17e-03 |
| FGFR1 mutant receptor activation | 24 | 2.82e-01 | 3.47e-01 | 0.2970 | 0.218000 | 0.199000 | 0.036000 | 6.49e-02 | 9.16e-02 | 7.60e-01 |
| Adherens junctions interactions | 16 | 1.08e-01 | 1.58e-01 | 0.2970 | 0.050800 | 0.171000 | -0.237000 | 7.25e-01 | 2.37e-01 | 1.00e-01 |
| Metabolism of steroids | 117 | 3.80e-04 | 1.30e-03 | 0.2960 | 0.189000 | 0.226000 | 0.027700 | 4.00e-04 | 2.40e-05 | 6.05e-01 |
| Ion channel transport | 131 | 1.20e-04 | 4.80e-04 | 0.2950 | 0.199000 | 0.177000 | -0.127000 | 8.28e-05 | 4.75e-04 | 1.24e-02 |
| Other interleukin signaling | 18 | 1.33e-01 | 1.88e-01 | 0.2950 | 0.051800 | 0.116000 | -0.266000 | 7.03e-01 | 3.95e-01 | 5.07e-02 |
| Nicotinamide salvaging | 14 | 1.95e-01 | 2.57e-01 | 0.2940 | -0.097600 | 0.080400 | 0.265000 | 5.27e-01 | 6.02e-01 | 8.59e-02 |
| NOTCH4 Intracellular Domain Regulates Transcription | 17 | 1.36e-01 | 1.91e-01 | 0.2940 | 0.106000 | 0.261000 | -0.082800 | 4.51e-01 | 6.25e-02 | 5.54e-01 |
| CDT1 association with the CDC6:ORC:origin complex | 57 | 9.81e-05 | 4.03e-04 | 0.2930 | 0.259000 | 0.051600 | -0.125000 | 7.05e-04 | 5.00e-01 | 1.02e-01 |
| Signaling by Rho GTPases | 365 | 1.43e-11 | 2.43e-10 | 0.2920 | 0.207000 | 0.185000 | -0.091000 | 1.12e-11 | 1.29e-09 | 2.82e-03 |
| RNA Polymerase III Transcription Initiation | 36 | 1.07e-01 | 1.56e-01 | 0.2920 | -0.172000 | -0.208000 | -0.112000 | 7.48e-02 | 3.07e-02 | 2.46e-01 |
| Signaling by ERBB2 | 44 | 2.58e-02 | 4.73e-02 | 0.2910 | 0.167000 | 0.080100 | -0.225000 | 5.59e-02 | 3.58e-01 | 9.70e-03 |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | 72 | 3.01e-03 | 7.65e-03 | 0.2910 | -0.156000 | -0.244000 | 0.028800 | 2.25e-02 | 3.48e-04 | 6.73e-01 |
| Nucleobase catabolism | 28 | 8.33e-02 | 1.27e-01 | 0.2910 | 0.247000 | 0.110000 | -0.107000 | 2.37e-02 | 3.15e-01 | 3.27e-01 |
| RUNX3 regulates p14-ARF | 10 | 5.18e-01 | 5.78e-01 | 0.2900 | 0.124000 | 0.248000 | 0.088300 | 4.98e-01 | 1.75e-01 | 6.29e-01 |
| Inwardly rectifying K+ channels | 23 | 2.68e-01 | 3.32e-01 | 0.2900 | 0.222000 | 0.178000 | 0.055300 | 6.49e-02 | 1.38e-01 | 6.46e-01 |
| Base Excision Repair | 58 | 2.99e-03 | 7.62e-03 | 0.2900 | -0.063400 | -0.166000 | -0.229000 | 4.03e-01 | 2.84e-02 | 2.54e-03 |
| Serotonin Neurotransmitter Release Cycle | 14 | 2.81e-01 | 3.46e-01 | 0.2900 | -0.040800 | -0.036300 | -0.285000 | 7.91e-01 | 8.14e-01 | 6.49e-02 |
| Integrin cell surface interactions | 52 | 1.20e-02 | 2.47e-02 | 0.2900 | 0.208000 | 0.097400 | -0.177000 | 9.46e-03 | 2.25e-01 | 2.73e-02 |
| ISG15 antiviral mechanism | 72 | 3.66e-03 | 8.98e-03 | 0.2900 | -0.152000 | -0.142000 | 0.202000 | 2.58e-02 | 3.67e-02 | 3.10e-03 |
| Interconversion of nucleotide di- and triphosphates | 27 | 6.92e-04 | 2.15e-03 | 0.2890 | 0.097000 | -0.206000 | -0.178000 | 3.83e-01 | 6.39e-02 | 1.10e-01 |
| Neurexins and neuroligins | 36 | 2.14e-02 | 4.06e-02 | 0.2890 | -0.066000 | -0.057000 | -0.275000 | 4.93e-01 | 5.54e-01 | 4.27e-03 |
| DAG and IP3 signaling | 33 | 7.08e-02 | 1.12e-01 | 0.2880 | 0.117000 | 0.118000 | -0.235000 | 2.44e-01 | 2.40e-01 | 1.95e-02 |
| Signaling by FGFR1 | 38 | 1.42e-01 | 1.98e-01 | 0.2880 | 0.198000 | 0.192000 | -0.080800 | 3.44e-02 | 4.03e-02 | 3.89e-01 |
| Negative regulation of MAPK pathway | 42 | 7.58e-02 | 1.18e-01 | 0.2880 | 0.192000 | 0.146000 | -0.157000 | 3.13e-02 | 1.01e-01 | 7.85e-02 |
| Cell-Cell communication | 85 | 3.89e-04 | 1.32e-03 | 0.2870 | 0.143000 | 0.058300 | -0.242000 | 2.24e-02 | 3.53e-01 | 1.16e-04 |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 80 | 3.04e-03 | 7.71e-03 | 0.2870 | 0.172000 | 0.133000 | -0.187000 | 7.69e-03 | 4.01e-02 | 3.78e-03 |
| Cyclin A/B1/B2 associated events during G2/M transition | 24 | 3.62e-02 | 6.30e-02 | 0.2870 | 0.119000 | 0.029200 | 0.260000 | 3.15e-01 | 8.05e-01 | 2.76e-02 |
| CRMPs in Sema3A signaling | 14 | 9.87e-02 | 1.48e-01 | 0.2870 | -0.016100 | 0.128000 | -0.256000 | 9.17e-01 | 4.07e-01 | 9.70e-02 |
| TICAM1, RIP1-mediated IKK complex recruitment | 19 | 2.70e-01 | 3.35e-01 | 0.2870 | 0.248000 | 0.144000 | -0.010000 | 6.15e-02 | 2.78e-01 | 9.40e-01 |
| DNA Damage/Telomere Stress Induced Senescence | 44 | 6.14e-02 | 9.94e-02 | 0.2860 | 0.190000 | 0.137000 | -0.165000 | 2.90e-02 | 1.17e-01 | 5.85e-02 |
| Cell junction organization | 57 | 5.87e-03 | 1.34e-02 | 0.2860 | 0.162000 | 0.057800 | -0.228000 | 3.45e-02 | 4.50e-01 | 2.85e-03 |
| Interleukin receptor SHC signaling | 23 | 6.94e-02 | 1.10e-01 | 0.2860 | 0.100000 | 0.239000 | -0.119000 | 4.04e-01 | 4.68e-02 | 3.21e-01 |
| Termination of O-glycan biosynthesis | 16 | 1.87e-01 | 2.48e-01 | 0.2860 | 0.034200 | 0.094300 | -0.267000 | 8.13e-01 | 5.14e-01 | 6.40e-02 |
| Tryptophan catabolism | 12 | 3.66e-01 | 4.34e-01 | 0.2850 | 0.225000 | 0.125000 | 0.123000 | 1.77e-01 | 4.54e-01 | 4.62e-01 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 18 | 3.52e-01 | 4.19e-01 | 0.2850 | 0.236000 | 0.142000 | -0.071500 | 8.25e-02 | 2.97e-01 | 5.99e-01 |
| CDK-mediated phosphorylation and removal of Cdc6 | 71 | 7.62e-05 | 3.23e-04 | 0.2840 | 0.245000 | 0.063400 | -0.129000 | 3.64e-04 | 3.55e-01 | 5.94e-02 |
| Telomere Maintenance | 80 | 1.21e-04 | 4.80e-04 | 0.2840 | -0.045900 | -0.184000 | -0.211000 | 4.77e-01 | 4.50e-03 | 1.10e-03 |
| Role of LAT2/NTAL/LAB on calcium mobilization | 74 | 5.16e-06 | 3.15e-05 | 0.2830 | -0.052600 | -0.190000 | 0.203000 | 4.34e-01 | 4.76e-03 | 2.48e-03 |
| Signaling by TGF-beta Receptor Complex | 72 | 5.73e-03 | 1.31e-02 | 0.2830 | 0.194000 | 0.119000 | -0.168000 | 4.42e-03 | 8.12e-02 | 1.35e-02 |
| Diseases associated with glycosaminoglycan metabolism | 26 | 1.29e-01 | 1.84e-01 | 0.2830 | 0.091200 | 0.052100 | -0.263000 | 4.21e-01 | 6.46e-01 | 2.05e-02 |
| Neurotransmitter receptors and postsynaptic signal transmission | 123 | 2.34e-04 | 8.50e-04 | 0.2830 | 0.172000 | 0.166000 | -0.151000 | 1.01e-03 | 1.43e-03 | 3.91e-03 |
| NOD1/2 Signaling Pathway | 32 | 1.70e-01 | 2.31e-01 | 0.2820 | 0.225000 | 0.169000 | 0.005720 | 2.75e-02 | 9.70e-02 | 9.55e-01 |
| DCC mediated attractive signaling | 13 | 3.78e-01 | 4.45e-01 | 0.2820 | 0.001390 | -0.078400 | -0.271000 | 9.93e-01 | 6.24e-01 | 9.11e-02 |
| SCF(Skp2)-mediated degradation of p27/p21 | 60 | 5.73e-04 | 1.85e-03 | 0.2820 | 0.246000 | 0.071400 | -0.118000 | 1.00e-03 | 3.39e-01 | 1.14e-01 |
| p53-Dependent G1 DNA Damage Response | 63 | 1.07e-03 | 3.12e-03 | 0.2810 | 0.236000 | 0.080600 | -0.129000 | 1.19e-03 | 2.69e-01 | 7.70e-02 |
| p53-Dependent G1/S DNA damage checkpoint | 63 | 1.07e-03 | 3.12e-03 | 0.2810 | 0.236000 | 0.080600 | -0.129000 | 1.19e-03 | 2.69e-01 | 7.70e-02 |
| Phospholipid metabolism | 184 | 7.69e-06 | 4.43e-05 | 0.2810 | 0.181000 | 0.183000 | -0.112000 | 2.30e-05 | 1.81e-05 | 9.06e-03 |
| Assembly and cell surface presentation of NMDA receptors | 18 | 3.09e-01 | 3.74e-01 | 0.2800 | -0.109000 | -0.207000 | -0.153000 | 4.23e-01 | 1.28e-01 | 2.61e-01 |
| Assembly of collagen fibrils and other multimeric structures | 42 | 5.09e-02 | 8.47e-02 | 0.2800 | 0.137000 | 0.156000 | -0.188000 | 1.25e-01 | 8.06e-02 | 3.52e-02 |
| Bile acid and bile salt metabolism | 28 | 2.17e-01 | 2.79e-01 | 0.2800 | 0.156000 | 0.218000 | 0.080900 | 1.53e-01 | 4.62e-02 | 4.59e-01 |
| Role of phospholipids in phagocytosis | 88 | 1.26e-04 | 4.96e-04 | 0.2800 | -0.109000 | -0.182000 | 0.183000 | 7.72e-02 | 3.22e-03 | 3.08e-03 |
| Heme biosynthesis | 14 | 3.41e-01 | 4.10e-01 | 0.2790 | 0.242000 | 0.097800 | -0.098200 | 1.17e-01 | 5.26e-01 | 5.24e-01 |
| Immune System | 1888 | 1.96e-54 | 1.07e-52 | 0.2790 | 0.197000 | 0.155000 | -0.122000 | 9.40e-46 | 5.65e-29 | 1.67e-18 |
| Regulation of FOXO transcriptional activity by acetylation | 10 | 5.51e-01 | 6.04e-01 | 0.2770 | 0.115000 | 0.163000 | -0.193000 | 5.28e-01 | 3.73e-01 | 2.92e-01 |
| Collagen chain trimerization | 27 | 1.03e-01 | 1.52e-01 | 0.2770 | 0.003530 | -0.071800 | -0.268000 | 9.75e-01 | 5.19e-01 | 1.61e-02 |
| Endosomal/Vacuolar pathway | 12 | 3.94e-01 | 4.60e-01 | 0.2770 | -0.098900 | -0.075500 | -0.247000 | 5.53e-01 | 6.51e-01 | 1.38e-01 |
| Mitochondrial iron-sulfur cluster biogenesis | 13 | 6.79e-02 | 1.08e-01 | 0.2760 | 0.254000 | -0.022400 | -0.108000 | 1.13e-01 | 8.89e-01 | 5.02e-01 |
| Downregulation of TGF-beta receptor signaling | 26 | 8.74e-02 | 1.32e-01 | 0.2760 | 0.193000 | 0.040600 | -0.193000 | 8.91e-02 | 7.20e-01 | 8.83e-02 |
| G1/S DNA Damage Checkpoints | 65 | 5.95e-04 | 1.91e-03 | 0.2750 | 0.233000 | 0.068100 | -0.128000 | 1.14e-03 | 3.42e-01 | 7.47e-02 |
| DNA Damage Recognition in GG-NER | 38 | 3.61e-02 | 6.28e-02 | 0.2740 | -0.010500 | -0.093700 | -0.258000 | 9.10e-01 | 3.18e-01 | 5.96e-03 |
| Transport of small molecules | 553 | 1.43e-17 | 3.25e-16 | 0.2740 | 0.193000 | 0.134000 | -0.141000 | 9.37e-15 | 6.51e-08 | 1.38e-08 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 71 | 1.93e-05 | 9.65e-05 | 0.2740 | 0.245000 | 0.041500 | -0.115000 | 3.54e-04 | 5.45e-01 | 9.39e-02 |
| Transcriptional regulation by RUNX3 | 90 | 3.52e-03 | 8.68e-03 | 0.2740 | 0.200000 | 0.135000 | -0.129000 | 1.04e-03 | 2.66e-02 | 3.38e-02 |
| Caspase-mediated cleavage of cytoskeletal proteins | 12 | 4.47e-01 | 5.10e-01 | 0.2740 | 0.099200 | 0.151000 | -0.206000 | 5.52e-01 | 3.67e-01 | 2.17e-01 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | 42 | 1.53e-02 | 3.04e-02 | 0.2730 | 0.105000 | -0.027800 | -0.251000 | 2.40e-01 | 7.56e-01 | 4.90e-03 |
| HIV Transcription Elongation | 42 | 1.53e-02 | 3.04e-02 | 0.2730 | 0.105000 | -0.027800 | -0.251000 | 2.40e-01 | 7.56e-01 | 4.90e-03 |
| Tat-mediated elongation of the HIV-1 transcript | 42 | 1.53e-02 | 3.04e-02 | 0.2730 | 0.105000 | -0.027800 | -0.251000 | 2.40e-01 | 7.56e-01 | 4.90e-03 |
| FCERI mediated Ca+2 mobilization | 89 | 1.26e-05 | 6.73e-05 | 0.2720 | -0.077600 | -0.188000 | 0.180000 | 2.05e-01 | 2.13e-03 | 3.28e-03 |
| Sphingolipid de novo biosynthesis | 41 | 1.35e-01 | 1.90e-01 | 0.2720 | 0.213000 | 0.167000 | -0.024900 | 1.84e-02 | 6.37e-02 | 7.83e-01 |
| SUMOylation of DNA damage response and repair proteins | 77 | 1.03e-02 | 2.18e-02 | 0.2720 | -0.161000 | -0.210000 | 0.060000 | 1.45e-02 | 1.41e-03 | 3.63e-01 |
| Interleukin-7 signaling | 21 | 2.27e-01 | 2.89e-01 | 0.2720 | 0.077700 | 0.060000 | -0.253000 | 5.38e-01 | 6.34e-01 | 4.45e-02 |
| CD28 dependent Vav1 pathway | 12 | 5.42e-01 | 5.97e-01 | 0.2720 | 0.169000 | 0.084600 | -0.195000 | 3.09e-01 | 6.12e-01 | 2.43e-01 |
| RNA Polymerase III Transcription Termination | 23 | 5.59e-02 | 9.15e-02 | 0.2710 | -0.043500 | -0.238000 | -0.122000 | 7.18e-01 | 4.78e-02 | 3.10e-01 |
| SUMOylation of chromatin organization proteins | 57 | 1.91e-02 | 3.66e-02 | 0.2710 | -0.141000 | -0.231000 | 0.014400 | 6.50e-02 | 2.54e-03 | 8.50e-01 |
| PI3K/AKT Signaling in Cancer | 80 | 1.82e-03 | 5.00e-03 | 0.2700 | 0.110000 | 0.071400 | -0.237000 | 9.01e-02 | 2.70e-01 | 2.53e-04 |
| Interleukin-6 family signaling | 18 | 5.11e-01 | 5.71e-01 | 0.2700 | 0.205000 | 0.171000 | -0.038200 | 1.31e-01 | 2.08e-01 | 7.79e-01 |
| Platelet calcium homeostasis | 21 | 3.13e-01 | 3.78e-01 | 0.2700 | 0.140000 | 0.188000 | -0.133000 | 2.67e-01 | 1.36e-01 | 2.90e-01 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | 72 | 2.71e-05 | 1.29e-04 | 0.2700 | 0.244000 | 0.046000 | -0.105000 | 3.43e-04 | 5.00e-01 | 1.24e-01 |
| Metabolism of lipids | 620 | 1.00e-16 | 2.24e-15 | 0.2690 | 0.178000 | 0.183000 | -0.084400 | 3.73e-14 | 6.35e-15 | 3.34e-04 |
| Developmental Biology | 725 | 1.16e-28 | 3.75e-27 | 0.2690 | 0.136000 | 0.055200 | -0.225000 | 4.01e-10 | 1.14e-02 | 4.56e-25 |
| Synthesis of PIPs at the plasma membrane | 52 | 2.28e-02 | 4.27e-02 | 0.2690 | 0.135000 | 0.219000 | -0.079800 | 9.26e-02 | 6.38e-03 | 3.20e-01 |
| Biosynthesis of DHA-derived SPMs | 14 | 5.32e-01 | 5.89e-01 | 0.2680 | 0.198000 | 0.118000 | -0.137000 | 1.99e-01 | 4.44e-01 | 3.76e-01 |
| SUMOylation of DNA replication proteins | 46 | 6.22e-02 | 1.01e-01 | 0.2680 | -0.145000 | -0.184000 | 0.130000 | 8.95e-02 | 3.10e-02 | 1.26e-01 |
| Rho GTPase cycle | 125 | 4.78e-04 | 1.58e-03 | 0.2680 | 0.158000 | 0.184000 | -0.112000 | 2.25e-03 | 3.73e-04 | 3.01e-02 |
| Inositol phosphate metabolism | 42 | 2.08e-02 | 3.95e-02 | 0.2670 | 0.084400 | 0.150000 | -0.205000 | 3.44e-01 | 9.27e-02 | 2.17e-02 |
| Chromosome Maintenance | 105 | 1.40e-04 | 5.47e-04 | 0.2670 | -0.108000 | -0.223000 | -0.100000 | 5.64e-02 | 7.86e-05 | 7.55e-02 |
| ADORA2B mediated anti-inflammatory cytokines production | 73 | 1.75e-03 | 4.86e-03 | 0.2670 | 0.075100 | 0.082500 | -0.243000 | 2.68e-01 | 2.23e-01 | 3.35e-04 |
| Signaling by Hedgehog | 120 | 1.44e-04 | 5.62e-04 | 0.2670 | 0.177000 | 0.091000 | -0.178000 | 8.13e-04 | 8.51e-02 | 7.55e-04 |
| Cell death signalling via NRAGE, NRIF and NADE | 69 | 1.11e-02 | 2.30e-02 | 0.2670 | 0.138000 | 0.120000 | -0.194000 | 4.70e-02 | 8.54e-02 | 5.28e-03 |
| Lewis blood group biosynthesis | 13 | 4.19e-01 | 4.83e-01 | 0.2670 | 0.038700 | 0.034000 | -0.262000 | 8.09e-01 | 8.32e-01 | 1.02e-01 |
| Negative regulation of the PI3K/AKT network | 87 | 2.91e-03 | 7.46e-03 | 0.2670 | 0.139000 | 0.114000 | -0.196000 | 2.47e-02 | 6.57e-02 | 1.54e-03 |
| Laminin interactions | 21 | 1.60e-01 | 2.19e-01 | 0.2660 | 0.241000 | 0.087600 | -0.071400 | 5.62e-02 | 4.87e-01 | 5.71e-01 |
| Establishment of Sister Chromatid Cohesion | 11 | 1.05e-01 | 1.54e-01 | 0.2660 | 0.064700 | -0.143000 | 0.215000 | 7.10e-01 | 4.12e-01 | 2.17e-01 |
| mRNA Splicing - Major Pathway | 179 | 3.55e-11 | 5.30e-10 | 0.2660 | -0.003840 | -0.178000 | -0.197000 | 9.29e-01 | 3.83e-05 | 5.39e-06 |
| Interleukin-12 signaling | 44 | 8.19e-02 | 1.25e-01 | 0.2660 | 0.211000 | 0.128000 | -0.099100 | 1.56e-02 | 1.41e-01 | 2.56e-01 |
| Depolymerisation of the Nuclear Lamina | 15 | 4.21e-01 | 4.84e-01 | 0.2650 | 0.231000 | 0.130000 | 0.010000 | 1.22e-01 | 3.82e-01 | 9.46e-01 |
| Formation of the Early Elongation Complex | 33 | 3.82e-02 | 6.59e-02 | 0.2650 | 0.124000 | -0.027200 | -0.232000 | 2.17e-01 | 7.87e-01 | 2.11e-02 |
| Formation of the HIV-1 Early Elongation Complex | 33 | 3.82e-02 | 6.59e-02 | 0.2650 | 0.124000 | -0.027200 | -0.232000 | 2.17e-01 | 7.87e-01 | 2.11e-02 |
| Transcriptional Regulation by MECP2 | 47 | 5.92e-02 | 9.62e-02 | 0.2640 | 0.146000 | 0.103000 | -0.195000 | 8.39e-02 | 2.24e-01 | 2.07e-02 |
| PECAM1 interactions | 12 | 1.96e-01 | 2.57e-01 | 0.2640 | -0.007720 | 0.134000 | -0.228000 | 9.63e-01 | 4.23e-01 | 1.72e-01 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 75 | 4.30e-05 | 1.93e-04 | 0.2640 | 0.242000 | 0.054400 | -0.090800 | 2.98e-04 | 4.15e-01 | 1.74e-01 |
| Hedgehog 'off' state | 92 | 3.13e-04 | 1.10e-03 | 0.2640 | 0.164000 | 0.044300 | -0.201000 | 6.52e-03 | 4.63e-01 | 8.36e-04 |
| Nitric oxide stimulates guanylate cyclase | 16 | 1.97e-01 | 2.58e-01 | 0.2640 | 0.231000 | 0.047800 | -0.118000 | 1.10e-01 | 7.41e-01 | 4.15e-01 |
| CD209 (DC-SIGN) signaling | 20 | 4.38e-01 | 5.01e-01 | 0.2630 | 0.185000 | 0.136000 | -0.129000 | 1.51e-01 | 2.93e-01 | 3.19e-01 |
| Synthesis of PIPs at the early endosome membrane | 16 | 2.91e-01 | 3.56e-01 | 0.2630 | -0.010200 | 0.117000 | 0.235000 | 9.44e-01 | 4.17e-01 | 1.04e-01 |
| Pyruvate metabolism | 28 | 5.83e-02 | 9.51e-02 | 0.2630 | 0.244000 | 0.080100 | -0.055100 | 2.54e-02 | 4.63e-01 | 6.14e-01 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | 64 | 7.85e-04 | 2.40e-03 | 0.2620 | -0.029700 | -0.191000 | -0.176000 | 6.82e-01 | 8.08e-03 | 1.49e-02 |
| Regulation of Complement cascade | 94 | 4.52e-06 | 2.82e-05 | 0.2620 | -0.031400 | -0.127000 | 0.227000 | 5.99e-01 | 3.32e-02 | 1.47e-04 |
| Signaling by TGFB family members | 91 | 1.64e-03 | 4.57e-03 | 0.2620 | 0.180000 | 0.087400 | -0.168000 | 2.93e-03 | 1.49e-01 | 5.63e-03 |
| Apoptotic cleavage of cellular proteins | 34 | 2.60e-01 | 3.23e-01 | 0.2610 | 0.173000 | 0.195000 | -0.013200 | 8.03e-02 | 4.88e-02 | 8.94e-01 |
| Regulation of RUNX2 expression and activity | 66 | 7.66e-04 | 2.35e-03 | 0.2610 | 0.233000 | 0.069300 | -0.096300 | 1.08e-03 | 3.30e-01 | 1.76e-01 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | 74 | 4.30e-05 | 1.93e-04 | 0.2610 | 0.239000 | 0.049100 | -0.092200 | 3.71e-04 | 4.65e-01 | 1.70e-01 |
| N-glycan antennae elongation in the medial/trans-Golgi | 21 | 1.13e-01 | 1.64e-01 | 0.2610 | -0.026800 | 0.041600 | -0.256000 | 8.31e-01 | 7.42e-01 | 4.22e-02 |
| G alpha (12/13) signalling events | 68 | 2.96e-02 | 5.30e-02 | 0.2600 | 0.158000 | 0.169000 | -0.120000 | 2.43e-02 | 1.61e-02 | 8.74e-02 |
| Transcriptional regulation of pluripotent stem cells | 19 | 5.06e-01 | 5.66e-01 | 0.2600 | 0.183000 | 0.178000 | 0.050300 | 1.68e-01 | 1.79e-01 | 7.05e-01 |
| Triglyceride metabolism | 25 | 3.97e-01 | 4.62e-01 | 0.2600 | 0.187000 | 0.179000 | 0.025900 | 1.06e-01 | 1.22e-01 | 8.23e-01 |
| Activation of SMO | 13 | 3.06e-01 | 3.72e-01 | 0.2590 | 0.027000 | 0.111000 | -0.232000 | 8.66e-01 | 4.88e-01 | 1.48e-01 |
| Signaling by FGFR1 in disease | 31 | 1.90e-01 | 2.51e-01 | 0.2550 | 0.171000 | 0.145000 | 0.122000 | 9.84e-02 | 1.64e-01 | 2.41e-01 |
| Transport of Mature Transcript to Cytoplasm | 81 | 6.83e-03 | 1.52e-02 | 0.2550 | -0.136000 | -0.214000 | 0.028100 | 3.49e-02 | 8.72e-04 | 6.62e-01 |
| IRF3-mediated induction of type I IFN | 12 | 4.60e-01 | 5.22e-01 | 0.2540 | -0.034000 | -0.163000 | -0.193000 | 8.39e-01 | 3.29e-01 | 2.48e-01 |
| Stimuli-sensing channels | 71 | 4.11e-02 | 7.00e-02 | 0.2540 | 0.184000 | 0.151000 | -0.090800 | 7.48e-03 | 2.79e-02 | 1.86e-01 |
| FLT3 Signaling | 243 | 1.43e-07 | 1.33e-06 | 0.2540 | 0.163000 | 0.098600 | -0.168000 | 1.27e-05 | 8.11e-03 | 6.35e-06 |
| MAPK1/MAPK3 signaling | 234 | 1.85e-07 | 1.68e-06 | 0.2530 | 0.169000 | 0.094500 | -0.163000 | 8.07e-06 | 1.27e-02 | 1.78e-05 |
| O-linked glycosylation of mucins | 47 | 5.91e-02 | 9.61e-02 | 0.2530 | 0.129000 | 0.203000 | -0.077500 | 1.26e-01 | 1.58e-02 | 3.58e-01 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | 34 | 8.59e-02 | 1.30e-01 | 0.2530 | 0.050400 | -0.035000 | -0.245000 | 6.11e-01 | 7.24e-01 | 1.33e-02 |
| ABC transporters in lipid homeostasis | 14 | 5.44e-01 | 5.99e-01 | 0.2520 | -0.205000 | -0.138000 | -0.051000 | 1.85e-01 | 3.70e-01 | 7.41e-01 |
| Circadian Clock | 67 | 3.91e-02 | 6.71e-02 | 0.2520 | 0.173000 | 0.128000 | -0.131000 | 1.46e-02 | 7.02e-02 | 6.29e-02 |
| Viral Messenger RNA Synthesis | 44 | 9.48e-02 | 1.43e-01 | 0.2520 | -0.129000 | -0.212000 | -0.043400 | 1.39e-01 | 1.51e-02 | 6.19e-01 |
| Interleukin-12 family signaling | 53 | 5.54e-02 | 9.11e-02 | 0.2510 | 0.211000 | 0.128000 | -0.047700 | 7.79e-03 | 1.08e-01 | 5.48e-01 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | 11 | 3.66e-01 | 4.33e-01 | 0.2510 | 0.032300 | -0.149000 | -0.200000 | 8.53e-01 | 3.92e-01 | 2.52e-01 |
| Transcriptional regulation by RUNX2 | 100 | 5.06e-03 | 1.18e-02 | 0.2510 | 0.196000 | 0.129000 | -0.089300 | 6.97e-04 | 2.58e-02 | 1.23e-01 |
| mRNA Splicing | 187 | 4.33e-11 | 6.33e-10 | 0.2510 | -0.000579 | -0.176000 | -0.179000 | 9.89e-01 | 3.19e-05 | 2.52e-05 |
| Interferon Signaling | 177 | 3.24e-07 | 2.85e-06 | 0.2510 | -0.155000 | -0.038500 | 0.193000 | 3.74e-04 | 3.77e-01 | 9.23e-06 |
| NCAM1 interactions | 23 | 4.91e-01 | 5.53e-01 | 0.2500 | -0.180000 | -0.172000 | 0.023500 | 1.36e-01 | 1.54e-01 | 8.46e-01 |
| Xenobiotics | 11 | 5.22e-01 | 5.82e-01 | 0.2490 | -0.007920 | -0.125000 | -0.215000 | 9.64e-01 | 4.74e-01 | 2.16e-01 |
| FOXO-mediated transcription | 58 | 5.47e-02 | 9.02e-02 | 0.2490 | 0.147000 | 0.116000 | -0.164000 | 5.24e-02 | 1.27e-01 | 3.08e-02 |
| Regulation of innate immune responses to cytosolic DNA | 14 | 3.87e-01 | 4.53e-01 | 0.2480 | 0.018700 | -0.110000 | -0.222000 | 9.03e-01 | 4.76e-01 | 1.51e-01 |
| TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 17 | 3.38e-01 | 4.07e-01 | 0.2480 | 0.139000 | 0.014000 | -0.204000 | 3.20e-01 | 9.20e-01 | 1.45e-01 |
| RNA Polymerase III Transcription Initiation From Type 3 Promoter | 28 | 2.79e-01 | 3.45e-01 | 0.2470 | -0.127000 | -0.205000 | -0.055400 | 2.44e-01 | 6.08e-02 | 6.12e-01 |
| RAF/MAP kinase cascade | 229 | 5.00e-07 | 4.11e-06 | 0.2470 | 0.160000 | 0.088700 | -0.166000 | 3.15e-05 | 2.07e-02 | 1.42e-05 |
| Activation of BH3-only proteins | 29 | 1.77e-01 | 2.38e-01 | 0.2470 | 0.117000 | 0.031000 | -0.215000 | 2.75e-01 | 7.72e-01 | 4.47e-02 |
| VEGFR2 mediated cell proliferation | 18 | 5.38e-01 | 5.95e-01 | 0.2470 | 0.165000 | 0.126000 | -0.134000 | 2.25e-01 | 3.56e-01 | 3.27e-01 |
| TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain | 19 | 1.83e-01 | 2.44e-01 | 0.2470 | -0.076800 | -0.211000 | 0.102000 | 5.62e-01 | 1.11e-01 | 4.42e-01 |
| Cholesterol biosynthesis | 24 | 2.79e-01 | 3.45e-01 | 0.2470 | 0.092000 | 0.185000 | 0.135000 | 4.35e-01 | 1.17e-01 | 2.51e-01 |
| B-WICH complex positively regulates rRNA expression | 47 | 2.48e-03 | 6.52e-03 | 0.2470 | 0.141000 | -0.055200 | -0.195000 | 9.52e-02 | 5.13e-01 | 2.07e-02 |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 14 | 1.28e-01 | 1.83e-01 | 0.2460 | -0.030200 | 0.133000 | -0.204000 | 8.45e-01 | 3.87e-01 | 1.86e-01 |
| Protein localization | 157 | 5.06e-09 | 6.04e-08 | 0.2460 | 0.117000 | -0.056100 | -0.208000 | 1.14e-02 | 2.25e-01 | 6.55e-06 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | 38 | 9.92e-02 | 1.48e-01 | 0.2450 | -0.107000 | -0.215000 | -0.050100 | 2.54e-01 | 2.21e-02 | 5.93e-01 |
| Unfolded Protein Response (UPR) | 86 | 1.05e-02 | 2.21e-02 | 0.2430 | 0.183000 | 0.107000 | -0.119000 | 3.28e-03 | 8.72e-02 | 5.65e-02 |
| Protein-protein interactions at synapses | 56 | 1.28e-02 | 2.61e-02 | 0.2430 | 0.005970 | 0.015400 | -0.242000 | 9.38e-01 | 8.42e-01 | 1.73e-03 |
| Polo-like kinase mediated events | 15 | 2.92e-01 | 3.58e-01 | 0.2430 | 0.108000 | 0.033700 | 0.215000 | 4.70e-01 | 8.21e-01 | 1.50e-01 |
| Downstream signal transduction | 27 | 4.40e-01 | 5.02e-01 | 0.2420 | 0.163000 | 0.177000 | -0.024800 | 1.42e-01 | 1.12e-01 | 8.24e-01 |
| Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 11 | 3.86e-01 | 4.53e-01 | 0.2420 | -0.076200 | 0.104000 | 0.205000 | 6.62e-01 | 5.52e-01 | 2.40e-01 |
| Complement cascade | 98 | 1.46e-05 | 7.67e-05 | 0.2410 | -0.030500 | -0.126000 | 0.203000 | 6.02e-01 | 3.06e-02 | 5.06e-04 |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | 84 | 1.25e-04 | 4.93e-04 | 0.2410 | -0.062100 | -0.176000 | 0.153000 | 3.25e-01 | 5.32e-03 | 1.54e-02 |
| Muscle contraction | 140 | 1.39e-03 | 3.96e-03 | 0.2410 | 0.147000 | 0.172000 | -0.082200 | 2.68e-03 | 4.29e-04 | 9.30e-02 |
| Transcription of E2F targets under negative control by DREAM complex | 19 | 2.74e-02 | 4.98e-02 | 0.2410 | 0.011100 | -0.241000 | -0.010200 | 9.33e-01 | 6.95e-02 | 9.39e-01 |
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 17 | 6.02e-01 | 6.51e-01 | 0.2410 | -0.147000 | -0.190000 | 0.012400 | 2.93e-01 | 1.74e-01 | 9.30e-01 |
| Synthesis, secretion, and deacylation of Ghrelin | 11 | 4.85e-01 | 5.47e-01 | 0.2410 | -0.064100 | -0.216000 | -0.084700 | 7.13e-01 | 2.15e-01 | 6.27e-01 |
| Signaling by PDGFR in disease | 19 | 3.84e-01 | 4.51e-01 | 0.2400 | 0.169000 | 0.117000 | 0.124000 | 2.03e-01 | 3.75e-01 | 3.50e-01 |
| MAPK family signaling cascades | 267 | 1.04e-07 | 1.00e-06 | 0.2400 | 0.168000 | 0.090400 | -0.145000 | 2.31e-06 | 1.10e-02 | 4.38e-05 |
| Signaling by ERBB2 in Cancer | 21 | 8.81e-02 | 1.33e-01 | 0.2400 | 0.217000 | 0.017100 | -0.100000 | 8.51e-02 | 8.92e-01 | 4.27e-01 |
| Peroxisomal protein import | 57 | 1.18e-01 | 1.71e-01 | 0.2400 | 0.182000 | 0.144000 | -0.058200 | 1.74e-02 | 5.93e-02 | 4.47e-01 |
| Acyl chain remodelling of PE | 20 | 3.81e-01 | 4.48e-01 | 0.2390 | 0.187000 | 0.081800 | -0.125000 | 1.47e-01 | 5.27e-01 | 3.34e-01 |
| Formation of TC-NER Pre-Incision Complex | 53 | 5.20e-04 | 1.69e-03 | 0.2390 | 0.110000 | -0.102000 | -0.187000 | 1.68e-01 | 1.98e-01 | 1.88e-02 |
| Insulin receptor signalling cascade | 39 | 2.15e-01 | 2.76e-01 | 0.2390 | 0.163000 | 0.118000 | -0.130000 | 7.82e-02 | 2.04e-01 | 1.61e-01 |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | 16 | 5.86e-01 | 6.36e-01 | 0.2390 | -0.135000 | -0.162000 | 0.113000 | 3.51e-01 | 2.62e-01 | 4.33e-01 |
| Signaling by FGFR2 | 60 | 1.03e-02 | 2.19e-02 | 0.2390 | 0.103000 | -0.014300 | -0.215000 | 1.70e-01 | 8.48e-01 | 3.95e-03 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | 52 | 2.67e-02 | 4.87e-02 | 0.2390 | 0.201000 | 0.074500 | -0.106000 | 1.23e-02 | 3.53e-01 | 1.88e-01 |
| Dopamine Neurotransmitter Release Cycle | 19 | 3.78e-01 | 4.45e-01 | 0.2380 | -0.040300 | -0.087800 | -0.218000 | 7.61e-01 | 5.07e-01 | 1.00e-01 |
| Adrenaline,noradrenaline inhibits insulin secretion | 24 | 4.35e-01 | 4.98e-01 | 0.2380 | 0.142000 | 0.136000 | -0.133000 | 2.27e-01 | 2.48e-01 | 2.58e-01 |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 78 | 2.20e-04 | 8.09e-04 | 0.2380 | -0.007110 | -0.176000 | -0.160000 | 9.14e-01 | 7.33e-03 | 1.44e-02 |
| Transcriptional regulation by RUNX1 | 184 | 2.83e-05 | 1.34e-04 | 0.2380 | 0.152000 | 0.086500 | -0.161000 | 3.60e-04 | 4.30e-02 | 1.73e-04 |
| DNA Damage Bypass | 47 | 2.70e-02 | 4.92e-02 | 0.2380 | -0.091100 | -0.219000 | 0.002160 | 2.80e-01 | 9.23e-03 | 9.80e-01 |
| Binding and Uptake of Ligands by Scavenger Receptors | 91 | 1.20e-07 | 1.15e-06 | 0.2380 | 0.022500 | -0.142000 | 0.189000 | 7.10e-01 | 1.93e-02 | 1.81e-03 |
| Synthesis of bile acids and bile salts | 24 | 4.57e-01 | 5.19e-01 | 0.2380 | 0.143000 | 0.176000 | 0.072000 | 2.25e-01 | 1.36e-01 | 5.41e-01 |
| Unblocking of NMDA receptors, glutamate binding and activation | 12 | 6.30e-01 | 6.78e-01 | 0.2380 | -0.197000 | -0.125000 | -0.045400 | 2.37e-01 | 4.55e-01 | 7.85e-01 |
| Signaling by WNT in cancer | 30 | 1.12e-01 | 1.63e-01 | 0.2380 | 0.082200 | 0.175000 | -0.138000 | 4.36e-01 | 9.69e-02 | 1.91e-01 |
| Signal Transduction | 1870 | 1.50e-40 | 6.81e-39 | 0.2370 | 0.153000 | 0.128000 | -0.128000 | 4.52e-28 | 3.57e-20 | 5.80e-20 |
| HCMV Late Events | 69 | 2.59e-02 | 4.74e-02 | 0.2370 | 0.169000 | 0.086300 | -0.143000 | 1.54e-02 | 2.15e-01 | 4.01e-02 |
| Tight junction interactions | 18 | 1.43e-01 | 1.99e-01 | 0.2370 | 0.005470 | -0.191000 | -0.140000 | 9.68e-01 | 1.61e-01 | 3.02e-01 |
| Factors involved in megakaryocyte development and platelet production | 115 | 1.02e-02 | 2.17e-02 | 0.2370 | 0.180000 | 0.150000 | -0.037000 | 8.52e-04 | 5.51e-03 | 4.93e-01 |
| Regulation of MECP2 expression and activity | 28 | 3.49e-01 | 4.18e-01 | 0.2370 | 0.135000 | 0.133000 | -0.142000 | 2.15e-01 | 2.22e-01 | 1.93e-01 |
| Telomere Extension By Telomerase | 23 | 4.37e-01 | 5.00e-01 | 0.2370 | -0.126000 | -0.181000 | -0.086000 | 2.96e-01 | 1.32e-01 | 4.75e-01 |
| Mitochondrial biogenesis | 88 | 1.13e-04 | 4.59e-04 | 0.2350 | 0.165000 | -0.001750 | -0.167000 | 7.61e-03 | 9.77e-01 | 6.62e-03 |
| Interleukin-2 family signaling | 38 | 7.33e-02 | 1.15e-01 | 0.2350 | 0.093400 | 0.192000 | -0.097900 | 3.19e-01 | 4.08e-02 | 2.96e-01 |
| Diseases associated with O-glycosylation of proteins | 48 | 2.37e-03 | 6.27e-03 | 0.2350 | -0.203000 | -0.050800 | -0.105000 | 1.48e-02 | 5.42e-01 | 2.07e-01 |
| Intrinsic Pathway for Apoptosis | 52 | 6.74e-02 | 1.07e-01 | 0.2340 | 0.182000 | 0.087900 | -0.119000 | 2.35e-02 | 2.73e-01 | 1.38e-01 |
| Retrograde transport at the Trans-Golgi-Network | 49 | 1.96e-01 | 2.57e-01 | 0.2340 | 0.176000 | 0.146000 | -0.047100 | 3.30e-02 | 7.70e-02 | 5.68e-01 |
| G alpha (q) signalling events | 130 | 4.61e-04 | 1.53e-03 | 0.2330 | 0.097700 | 0.097000 | -0.188000 | 5.43e-02 | 5.62e-02 | 2.06e-04 |
| Positive epigenetic regulation of rRNA expression | 62 | 1.19e-03 | 3.45e-03 | 0.2330 | 0.070900 | -0.103000 | -0.196000 | 3.34e-01 | 1.61e-01 | 7.55e-03 |
| Sema3A PAK dependent Axon repulsion | 16 | 5.03e-01 | 5.65e-01 | 0.2320 | 0.076600 | 0.065000 | -0.209000 | 5.96e-01 | 6.53e-01 | 1.47e-01 |
| TNFR2 non-canonical NF-kB pathway | 95 | 9.19e-06 | 5.21e-05 | 0.2320 | 0.158000 | -0.030400 | -0.167000 | 7.91e-03 | 6.09e-01 | 4.80e-03 |
| Metabolism | 1756 | 1.05e-49 | 5.50e-48 | 0.2320 | 0.137000 | 0.052900 | -0.179000 | 1.26e-21 | 2.35e-04 | 8.76e-36 |
| Transmission across Chemical Synapses | 169 | 4.71e-04 | 1.56e-03 | 0.2320 | 0.139000 | 0.141000 | -0.120000 | 1.77e-03 | 1.59e-03 | 7.13e-03 |
| Insulin processing | 20 | 4.89e-01 | 5.52e-01 | 0.2310 | 0.162000 | 0.135000 | 0.095400 | 2.11e-01 | 2.95e-01 | 4.60e-01 |
| Interleukin-37 signaling | 19 | 1.88e-01 | 2.49e-01 | 0.2310 | 0.063000 | 0.214000 | -0.060200 | 6.34e-01 | 1.07e-01 | 6.49e-01 |
| Formation of HIV elongation complex in the absence of HIV Tat | 44 | 5.13e-02 | 8.51e-02 | 0.2310 | 0.101000 | -0.013300 | -0.207000 | 2.47e-01 | 8.79e-01 | 1.76e-02 |
| Signaling by ERBB2 TMD/JMD mutants | 17 | 1.45e-01 | 2.01e-01 | 0.2300 | 0.189000 | -0.018800 | -0.129000 | 1.77e-01 | 8.93e-01 | 3.57e-01 |
| Regulation of TP53 Activity through Methylation | 19 | 5.39e-01 | 5.95e-01 | 0.2300 | -0.120000 | -0.158000 | -0.115000 | 3.66e-01 | 2.32e-01 | 3.85e-01 |
| RAS processing | 19 | 1.81e-01 | 2.41e-01 | 0.2300 | 0.126000 | -0.051500 | -0.185000 | 3.40e-01 | 6.98e-01 | 1.64e-01 |
| Regulation of beta-cell development | 19 | 5.14e-01 | 5.73e-01 | 0.2290 | 0.122000 | 0.170000 | -0.092800 | 3.58e-01 | 1.99e-01 | 4.84e-01 |
| Assembly of the pre-replicative complex | 66 | 7.56e-04 | 2.33e-03 | 0.2290 | 0.193000 | 0.013400 | -0.123000 | 6.82e-03 | 8.51e-01 | 8.34e-02 |
| Processing of Capped Intron-Containing Pre-mRNA | 238 | 2.79e-11 | 4.46e-10 | 0.2280 | -0.035400 | -0.193000 | -0.118000 | 3.46e-01 | 3.11e-07 | 1.76e-03 |
| Infectious disease | 723 | 2.77e-28 | 8.76e-27 | 0.2280 | 0.117000 | -0.013000 | -0.195000 | 8.14e-08 | 5.53e-01 | 3.45e-19 |
| Glutathione conjugation | 26 | 4.92e-01 | 5.54e-01 | 0.2280 | 0.175000 | 0.145000 | -0.019400 | 1.22e-01 | 2.02e-01 | 8.64e-01 |
| TRAF3-dependent IRF activation pathway | 13 | 5.31e-01 | 5.89e-01 | 0.2280 | 0.048400 | 0.165000 | 0.149000 | 7.63e-01 | 3.02e-01 | 3.52e-01 |
| Dual incision in TC-NER | 65 | 1.50e-03 | 4.24e-03 | 0.2280 | -0.018100 | -0.185000 | -0.131000 | 8.00e-01 | 9.85e-03 | 6.73e-02 |
| Peroxisomal lipid metabolism | 27 | 4.80e-01 | 5.43e-01 | 0.2270 | 0.173000 | 0.148000 | -0.003510 | 1.21e-01 | 1.84e-01 | 9.75e-01 |
| Synthesis of very long-chain fatty acyl-CoAs | 21 | 3.66e-01 | 4.33e-01 | 0.2270 | 0.200000 | 0.089700 | -0.060500 | 1.13e-01 | 4.77e-01 | 6.31e-01 |
| Acyl chain remodelling of PG | 11 | 7.96e-01 | 8.25e-01 | 0.2260 | 0.175000 | 0.138000 | -0.034900 | 3.14e-01 | 4.28e-01 | 8.41e-01 |
| Purine salvage | 12 | 4.12e-01 | 4.77e-01 | 0.2240 | 0.210000 | 0.042800 | -0.063200 | 2.08e-01 | 7.97e-01 | 7.04e-01 |
| Disorders of transmembrane transporters | 145 | 6.31e-05 | 2.74e-04 | 0.2230 | 0.152000 | 0.040500 | -0.159000 | 1.59e-03 | 4.00e-01 | 9.59e-04 |
| Neuronal System | 253 | 1.85e-06 | 1.27e-05 | 0.2230 | 0.111000 | 0.132000 | -0.142000 | 2.35e-03 | 3.03e-04 | 1.02e-04 |
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 25 | 4.51e-01 | 5.13e-01 | 0.2230 | 0.123000 | 0.185000 | 0.014500 | 2.86e-01 | 1.09e-01 | 9.00e-01 |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 10 | 3.23e-01 | 3.89e-01 | 0.2230 | 0.133000 | -0.090500 | -0.154000 | 4.65e-01 | 6.20e-01 | 4.00e-01 |
| Vitamin B5 (pantothenate) metabolism | 17 | 6.63e-01 | 7.08e-01 | 0.2230 | 0.142000 | 0.159000 | 0.065500 | 3.12e-01 | 2.57e-01 | 6.40e-01 |
| Metabolism of nucleotides | 86 | 1.63e-05 | 8.38e-05 | 0.2220 | 0.109000 | -0.089400 | -0.172000 | 8.17e-02 | 1.52e-01 | 5.72e-03 |
| RNA Pol II CTD phosphorylation and interaction with CE | 27 | 7.60e-02 | 1.18e-01 | 0.2220 | 0.138000 | -0.043000 | -0.169000 | 2.16e-01 | 6.99e-01 | 1.28e-01 |
| RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 27 | 7.60e-02 | 1.18e-01 | 0.2220 | 0.138000 | -0.043000 | -0.169000 | 2.16e-01 | 6.99e-01 | 1.28e-01 |
| Death Receptor Signalling | 131 | 5.07e-03 | 1.18e-02 | 0.2210 | 0.142000 | 0.110000 | -0.128000 | 4.98e-03 | 2.94e-02 | 1.12e-02 |
| Deubiquitination | 241 | 5.82e-05 | 2.54e-04 | 0.2210 | 0.175000 | 0.127000 | -0.045000 | 2.90e-06 | 6.84e-04 | 2.29e-01 |
| Phase 4 - resting membrane potential | 10 | 8.21e-01 | 8.45e-01 | 0.2200 | 0.133000 | 0.174000 | 0.023600 | 4.66e-01 | 3.40e-01 | 8.97e-01 |
| Aflatoxin activation and detoxification | 14 | 6.34e-01 | 6.81e-01 | 0.2190 | 0.158000 | 0.071400 | -0.134000 | 3.07e-01 | 6.44e-01 | 3.86e-01 |
| Deadenylation of mRNA | 22 | 4.72e-03 | 1.11e-02 | 0.2190 | 0.153000 | -0.106000 | 0.116000 | 2.15e-01 | 3.91e-01 | 3.47e-01 |
| Fatty acid metabolism | 151 | 3.54e-03 | 8.70e-03 | 0.2180 | 0.149000 | 0.119000 | -0.105000 | 1.56e-03 | 1.13e-02 | 2.53e-02 |
| Regulation of APC/C activators between G1/S and early anaphase | 79 | 4.07e-05 | 1.86e-04 | 0.2180 | 0.202000 | 0.004980 | -0.083200 | 1.94e-03 | 9.39e-01 | 2.01e-01 |
| Meiotic synapsis | 45 | 1.99e-01 | 2.60e-01 | 0.2170 | 0.171000 | 0.102000 | -0.085800 | 4.66e-02 | 2.38e-01 | 3.19e-01 |
| Disease | 1292 | 2.36e-33 | 8.24e-32 | 0.2160 | 0.125000 | 0.043300 | -0.171000 | 4.62e-14 | 9.01e-03 | 4.04e-25 |
| Class I MHC mediated antigen processing & presentation | 348 | 8.80e-07 | 6.72e-06 | 0.2160 | 0.172000 | 0.123000 | -0.044900 | 3.58e-08 | 7.73e-05 | 1.50e-01 |
| Processing of Capped Intronless Pre-mRNA | 28 | 1.79e-01 | 2.40e-01 | 0.2160 | -0.049200 | -0.182000 | -0.105000 | 6.52e-01 | 9.47e-02 | 3.37e-01 |
| Potassium Channels | 62 | 9.65e-02 | 1.44e-01 | 0.2160 | 0.119000 | 0.179000 | -0.017800 | 1.06e-01 | 1.46e-02 | 8.09e-01 |
| VEGFR2 mediated vascular permeability | 26 | 3.01e-01 | 3.66e-01 | 0.2150 | 0.081100 | 0.135000 | -0.146000 | 4.74e-01 | 2.33e-01 | 1.96e-01 |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | 36 | 2.18e-01 | 2.80e-01 | 0.2150 | 0.085600 | 0.104000 | -0.167000 | 3.74e-01 | 2.81e-01 | 8.24e-02 |
| Metabolism of cofactors | 19 | 4.39e-01 | 5.02e-01 | 0.2150 | 0.191000 | 0.096400 | 0.022700 | 1.50e-01 | 4.67e-01 | 8.64e-01 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | 21 | 1.01e-01 | 1.51e-01 | 0.2150 | -0.027600 | -0.210000 | 0.033900 | 8.27e-01 | 9.57e-02 | 7.88e-01 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 21 | 1.01e-01 | 1.51e-01 | 0.2150 | -0.027600 | -0.210000 | 0.033900 | 8.27e-01 | 9.57e-02 | 7.88e-01 |
| NRAGE signals death through JNK | 52 | 6.93e-02 | 1.10e-01 | 0.2140 | 0.069500 | 0.097700 | -0.178000 | 3.86e-01 | 2.23e-01 | 2.66e-02 |
| MECP2 regulates neuronal receptors and channels | 13 | 6.44e-01 | 6.90e-01 | 0.2140 | 0.113000 | 0.031300 | -0.179000 | 4.81e-01 | 8.45e-01 | 2.63e-01 |
| RNA Polymerase III Abortive And Retractive Initiation | 41 | 1.82e-01 | 2.42e-01 | 0.2140 | -0.091800 | -0.178000 | -0.075700 | 3.09e-01 | 4.90e-02 | 4.01e-01 |
| RNA Polymerase III Transcription | 41 | 1.82e-01 | 2.42e-01 | 0.2140 | -0.091800 | -0.178000 | -0.075700 | 3.09e-01 | 4.90e-02 | 4.01e-01 |
| Nephrin family interactions | 17 | 5.48e-01 | 6.03e-01 | 0.2130 | -0.059600 | -0.095000 | -0.181000 | 6.71e-01 | 4.98e-01 | 1.95e-01 |
| RNA Polymerase I Promoter Clearance | 66 | 2.72e-03 | 7.01e-03 | 0.2130 | 0.049300 | -0.109000 | -0.176000 | 4.89e-01 | 1.25e-01 | 1.33e-02 |
| RNA Polymerase I Transcription | 66 | 2.72e-03 | 7.01e-03 | 0.2130 | 0.049300 | -0.109000 | -0.176000 | 4.89e-01 | 1.25e-01 | 1.33e-02 |
| PI Metabolism | 79 | 1.81e-02 | 3.49e-02 | 0.2130 | 0.098900 | 0.175000 | -0.070500 | 1.29e-01 | 7.18e-03 | 2.78e-01 |
| RNA Polymerase I Promoter Escape | 47 | 3.46e-03 | 8.56e-03 | 0.2130 | 0.131000 | -0.071000 | -0.152000 | 1.21e-01 | 4.00e-01 | 7.11e-02 |
| CD28 co-stimulation | 33 | 1.04e-01 | 1.53e-01 | 0.2130 | -0.050600 | 0.002070 | -0.207000 | 6.15e-01 | 9.84e-01 | 3.98e-02 |
| Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 17 | 4.25e-01 | 4.88e-01 | 0.2130 | -0.080000 | -0.194000 | 0.034000 | 5.68e-01 | 1.66e-01 | 8.08e-01 |
| RNA Polymerase II Transcription Termination | 65 | 4.27e-03 | 1.02e-02 | 0.2120 | -0.029500 | -0.183000 | -0.103000 | 6.81e-01 | 1.06e-02 | 1.53e-01 |
| FCGR3A-mediated IL10 synthesis | 99 | 2.16e-03 | 5.83e-03 | 0.2110 | -0.072400 | -0.138000 | 0.142000 | 2.13e-01 | 1.74e-02 | 1.46e-02 |
| Constitutive Signaling by Aberrant PI3K in Cancer | 54 | 6.58e-02 | 1.06e-01 | 0.2100 | 0.059700 | -0.015300 | -0.201000 | 4.48e-01 | 8.46e-01 | 1.06e-02 |
| Cytosolic sulfonation of small molecules | 19 | 6.80e-01 | 7.24e-01 | 0.2100 | 0.142000 | 0.131000 | -0.082400 | 2.85e-01 | 3.22e-01 | 5.34e-01 |
| Keratan sulfate biosynthesis | 22 | 2.58e-01 | 3.22e-01 | 0.2070 | -0.016400 | 0.042700 | -0.202000 | 8.94e-01 | 7.29e-01 | 1.01e-01 |
| Nucleotide Excision Repair | 110 | 2.74e-04 | 9.73e-04 | 0.2070 | -0.009150 | -0.143000 | -0.149000 | 8.68e-01 | 9.35e-03 | 6.99e-03 |
| Ub-specific processing proteases | 170 | 2.08e-04 | 7.72e-04 | 0.2070 | 0.182000 | 0.095400 | -0.022200 | 4.18e-05 | 3.18e-02 | 6.17e-01 |
| Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | 16 | 2.26e-01 | 2.88e-01 | 0.2070 | -0.027300 | -0.193000 | 0.068800 | 8.50e-01 | 1.81e-01 | 6.34e-01 |
| Deadenylation-dependent mRNA decay | 53 | 1.00e-03 | 2.97e-03 | 0.2070 | -0.010200 | -0.206000 | -0.001770 | 8.97e-01 | 9.32e-03 | 9.82e-01 |
| Molecules associated with elastic fibres | 22 | 5.28e-01 | 5.87e-01 | 0.2070 | 0.111000 | 0.068600 | -0.160000 | 3.68e-01 | 5.77e-01 | 1.93e-01 |
| Protein methylation | 15 | 8.64e-02 | 1.31e-01 | 0.2060 | 0.128000 | -0.130000 | -0.095800 | 3.91e-01 | 3.84e-01 | 5.21e-01 |
| Cohesin Loading onto Chromatin | 10 | 3.77e-01 | 4.44e-01 | 0.2050 | 0.193000 | 0.015000 | 0.069500 | 2.92e-01 | 9.35e-01 | 7.04e-01 |
| Fertilization | 12 | 7.17e-01 | 7.59e-01 | 0.2050 | 0.082700 | 0.032900 | -0.185000 | 6.20e-01 | 8.44e-01 | 2.68e-01 |
| Transport of vitamins, nucleosides, and related molecules | 33 | 4.97e-01 | 5.60e-01 | 0.2050 | 0.147000 | 0.133000 | -0.052200 | 1.45e-01 | 1.85e-01 | 6.04e-01 |
| Synthesis of substrates in N-glycan biosythesis | 58 | 1.35e-01 | 1.90e-01 | 0.2050 | 0.128000 | 0.074600 | -0.141000 | 9.10e-02 | 3.26e-01 | 6.28e-02 |
| Post-translational protein modification | 1188 | 1.62e-19 | 4.09e-18 | 0.2050 | 0.152000 | 0.110000 | -0.082300 | 1.13e-18 | 1.78e-10 | 1.81e-06 |
| Association of TriC/CCT with target proteins during biosynthesis | 37 | 2.19e-01 | 2.80e-01 | 0.2040 | 0.046900 | 0.004010 | -0.199000 | 6.21e-01 | 9.66e-01 | 3.65e-02 |
| FRS-mediated FGFR3 signaling | 11 | 3.99e-01 | 4.64e-01 | 0.2040 | 0.188000 | 0.029500 | 0.073900 | 2.81e-01 | 8.66e-01 | 6.71e-01 |
| RUNX2 regulates bone development | 23 | 7.86e-02 | 1.21e-01 | 0.2040 | 0.013700 | 0.203000 | -0.013600 | 9.10e-01 | 9.18e-02 | 9.10e-01 |
| Host Interactions of HIV factors | 129 | 1.91e-05 | 9.62e-05 | 0.2040 | 0.085100 | -0.063600 | -0.174000 | 9.50e-02 | 2.12e-01 | 6.41e-04 |
| NoRC negatively regulates rRNA expression | 62 | 4.46e-03 | 1.07e-02 | 0.2040 | 0.138000 | -0.026200 | -0.147000 | 5.95e-02 | 7.22e-01 | 4.49e-02 |
| Synthesis of IP2, IP, and Ins in the cytosol | 13 | 6.60e-01 | 7.06e-01 | 0.2030 | 0.080900 | 0.179000 | 0.052300 | 6.14e-01 | 2.63e-01 | 7.44e-01 |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | 91 | 6.62e-03 | 1.48e-02 | 0.2030 | -0.038900 | -0.063200 | 0.189000 | 5.21e-01 | 2.98e-01 | 1.80e-03 |
| Amplification of signal from the kinetochores | 91 | 6.62e-03 | 1.48e-02 | 0.2030 | -0.038900 | -0.063200 | 0.189000 | 5.21e-01 | 2.98e-01 | 1.80e-03 |
| Resolution of Sister Chromatid Cohesion | 104 | 7.88e-04 | 2.40e-03 | 0.2030 | -0.007230 | -0.055100 | 0.196000 | 8.99e-01 | 3.31e-01 | 5.69e-04 |
| Formation of RNA Pol II elongation complex | 57 | 7.81e-02 | 1.21e-01 | 0.2020 | 0.150000 | 0.051800 | -0.126000 | 5.06e-02 | 4.99e-01 | 1.00e-01 |
| RNA Polymerase II Transcription Elongation | 57 | 7.81e-02 | 1.21e-01 | 0.2020 | 0.150000 | 0.051800 | -0.126000 | 5.06e-02 | 4.99e-01 | 1.00e-01 |
| Glucose metabolism | 83 | 4.22e-02 | 7.15e-02 | 0.2020 | 0.097700 | 0.064200 | -0.165000 | 1.24e-01 | 3.12e-01 | 9.50e-03 |
| Phase I - Functionalization of compounds | 61 | 1.07e-01 | 1.57e-01 | 0.2010 | 0.099000 | 0.055600 | -0.166000 | 1.81e-01 | 4.53e-01 | 2.49e-02 |
| Downstream TCR signaling | 100 | 2.34e-04 | 8.50e-04 | 0.2010 | 0.077100 | -0.075000 | -0.170000 | 1.83e-01 | 1.95e-01 | 3.33e-03 |
| Signaling by ERBB2 KD Mutants | 20 | 1.26e-01 | 1.80e-01 | 0.2010 | 0.184000 | -0.015100 | -0.078200 | 1.54e-01 | 9.07e-01 | 5.45e-01 |
| APC-Cdc20 mediated degradation of Nek2A | 26 | 4.57e-02 | 7.65e-02 | 0.2000 | 0.022400 | -0.186000 | -0.072300 | 8.43e-01 | 1.01e-01 | 5.23e-01 |
| Cyclin E associated events during G1/S transition | 83 | 1.11e-03 | 3.22e-03 | 0.2000 | 0.175000 | 0.020600 | -0.094100 | 5.71e-03 | 7.46e-01 | 1.39e-01 |
| G0 and Early G1 | 27 | 2.22e-02 | 4.18e-02 | 0.2000 | 0.019100 | -0.177000 | 0.090500 | 8.63e-01 | 1.11e-01 | 4.16e-01 |
| KSRP (KHSRP) binds and destabilizes mRNA | 17 | 2.94e-01 | 3.59e-01 | 0.2000 | -0.024100 | -0.189000 | -0.059200 | 8.64e-01 | 1.77e-01 | 6.73e-01 |
| Regulation of HSF1-mediated heat shock response | 79 | 2.28e-02 | 4.27e-02 | 0.1990 | -0.079900 | -0.179000 | -0.037100 | 2.20e-01 | 6.03e-03 | 5.69e-01 |
| ECM proteoglycans | 35 | 4.20e-01 | 4.84e-01 | 0.1990 | 0.115000 | 0.118000 | -0.110000 | 2.37e-01 | 2.27e-01 | 2.59e-01 |
| HCMV Infection | 96 | 1.14e-02 | 2.35e-02 | 0.1980 | 0.150000 | 0.053100 | -0.118000 | 1.09e-02 | 3.69e-01 | 4.63e-02 |
| Leishmania infection | 245 | 2.80e-04 | 9.88e-04 | 0.1980 | 0.149000 | 0.101000 | -0.082900 | 6.19e-05 | 6.59e-03 | 2.54e-02 |
| APC/C-mediated degradation of cell cycle proteins | 86 | 1.76e-04 | 6.60e-04 | 0.1970 | 0.189000 | 0.016200 | -0.056200 | 2.51e-03 | 7.96e-01 | 3.67e-01 |
| Regulation of mitotic cell cycle | 86 | 1.76e-04 | 6.60e-04 | 0.1970 | 0.189000 | 0.016200 | -0.056200 | 2.51e-03 | 7.96e-01 | 3.67e-01 |
| Phase 0 - rapid depolarisation | 28 | 1.69e-01 | 2.29e-01 | 0.1970 | -0.160000 | -0.011800 | 0.114000 | 1.42e-01 | 9.14e-01 | 2.95e-01 |
| Glucagon-type ligand receptors | 20 | 5.25e-01 | 5.85e-01 | 0.1970 | 0.043200 | 0.022300 | -0.191000 | 7.38e-01 | 8.63e-01 | 1.39e-01 |
| Metabolism of proteins | 1710 | 4.91e-46 | 2.30e-44 | 0.1970 | 0.130000 | 0.017100 | -0.146000 | 2.90e-19 | 2.40e-01 | 8.97e-24 |
| Signaling by PDGF | 44 | 4.08e-01 | 4.73e-01 | 0.1960 | 0.138000 | 0.132000 | -0.046400 | 1.13e-01 | 1.30e-01 | 5.94e-01 |
| Nuclear Envelope Breakdown | 53 | 1.49e-01 | 2.06e-01 | 0.1960 | -0.092600 | -0.139000 | 0.104000 | 2.44e-01 | 8.08e-02 | 1.91e-01 |
| Signaling by FGFR | 69 | 7.32e-02 | 1.15e-01 | 0.1950 | 0.091200 | 0.035500 | -0.169000 | 1.90e-01 | 6.10e-01 | 1.51e-02 |
| Neddylation | 218 | 1.05e-05 | 5.75e-05 | 0.1950 | 0.162000 | 0.058400 | -0.091300 | 3.56e-05 | 1.37e-01 | 2.02e-02 |
| Processing and activation of SUMO | 10 | 3.49e-01 | 4.18e-01 | 0.1950 | 0.060600 | -0.105000 | 0.152000 | 7.40e-01 | 5.64e-01 | 4.04e-01 |
| Global Genome Nucleotide Excision Repair (GG-NER) | 84 | 5.81e-03 | 1.32e-02 | 0.1950 | -0.044800 | -0.170000 | -0.083300 | 4.78e-01 | 6.93e-03 | 1.87e-01 |
| FCERI mediated MAPK activation | 90 | 8.34e-05 | 3.49e-04 | 0.1940 | 0.012200 | -0.111000 | 0.159000 | 8.41e-01 | 6.87e-02 | 9.05e-03 |
| Interaction between L1 and Ankyrins | 21 | 5.05e-01 | 5.66e-01 | 0.1940 | 0.006030 | 0.052700 | 0.187000 | 9.62e-01 | 6.76e-01 | 1.39e-01 |
| FRS-mediated FGFR1 signaling | 14 | 6.76e-01 | 7.21e-01 | 0.1940 | 0.143000 | 0.092500 | 0.092500 | 3.54e-01 | 5.49e-01 | 5.49e-01 |
| APC/C:Cdc20 mediated degradation of Cyclin B | 24 | 4.23e-02 | 7.16e-02 | 0.1940 | 0.082700 | -0.143000 | -0.101000 | 4.83e-01 | 2.25e-01 | 3.93e-01 |
| Post NMDA receptor activation events | 48 | 2.02e-01 | 2.63e-01 | 0.1930 | 0.097900 | 0.043000 | -0.161000 | 2.41e-01 | 6.06e-01 | 5.34e-02 |
| Synthesis of PIPs at the Golgi membrane | 16 | 4.08e-01 | 4.73e-01 | 0.1930 | 0.050100 | 0.180000 | -0.046300 | 7.28e-01 | 2.12e-01 | 7.49e-01 |
| SHC-mediated cascade:FGFR2 | 12 | 5.73e-01 | 6.25e-01 | 0.1930 | -0.042700 | -0.137000 | 0.128000 | 7.98e-01 | 4.10e-01 | 4.42e-01 |
| Activation of NMDA receptors and postsynaptic events | 58 | 1.02e-01 | 1.51e-01 | 0.1920 | 0.103000 | 0.023300 | -0.160000 | 1.74e-01 | 7.59e-01 | 3.45e-02 |
| Cellular response to heat stress | 93 | 1.69e-02 | 3.29e-02 | 0.1920 | -0.068300 | -0.161000 | -0.078200 | 2.55e-01 | 7.16e-03 | 1.92e-01 |
| PI-3K cascade:FGFR2 | 12 | 5.61e-01 | 6.14e-01 | 0.1920 | -0.053400 | -0.176000 | 0.055300 | 7.49e-01 | 2.92e-01 | 7.40e-01 |
| EGR2 and SOX10-mediated initiation of Schwann cell myelination | 22 | 1.51e-01 | 2.08e-01 | 0.1920 | 0.020500 | 0.175000 | -0.075000 | 8.68e-01 | 1.55e-01 | 5.43e-01 |
| Interleukin-20 family signaling | 17 | 7.39e-01 | 7.78e-01 | 0.1910 | 0.111000 | 0.152000 | -0.032500 | 4.28e-01 | 2.79e-01 | 8.16e-01 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 182 | 4.39e-03 | 1.05e-02 | 0.1900 | -0.135000 | -0.121000 | -0.056400 | 1.63e-03 | 4.80e-03 | 1.90e-01 |
| Voltage gated Potassium channels | 24 | 1.41e-01 | 1.97e-01 | 0.1900 | 0.014800 | 0.150000 | -0.115000 | 9.00e-01 | 2.02e-01 | 3.28e-01 |
| Fatty acyl-CoA biosynthesis | 33 | 5.50e-01 | 6.04e-01 | 0.1900 | 0.142000 | 0.115000 | -0.051800 | 1.59e-01 | 2.53e-01 | 6.06e-01 |
| Deactivation of the beta-catenin transactivating complex | 36 | 2.88e-01 | 3.53e-01 | 0.1890 | 0.034500 | 0.012300 | -0.186000 | 7.20e-01 | 8.99e-01 | 5.36e-02 |
| Regulation of actin dynamics for phagocytic cup formation | 123 | 1.95e-03 | 5.31e-03 | 0.1890 | 0.160000 | 0.080700 | 0.061100 | 2.20e-03 | 1.22e-01 | 2.42e-01 |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | 46 | 2.42e-01 | 3.03e-01 | 0.1880 | 0.092000 | 0.041000 | -0.159000 | 2.80e-01 | 6.30e-01 | 6.23e-02 |
| SUMOylation of transcription cofactors | 44 | 2.20e-01 | 2.81e-01 | 0.1880 | 0.063800 | 0.008980 | -0.177000 | 4.64e-01 | 9.18e-01 | 4.27e-02 |
| mRNA decay by 5' to 3' exoribonuclease | 15 | 4.05e-01 | 4.71e-01 | 0.1870 | -0.009810 | -0.168000 | -0.082700 | 9.48e-01 | 2.61e-01 | 5.79e-01 |
| Signaling by FGFR3 in disease | 13 | 3.08e-01 | 3.74e-01 | 0.1870 | 0.017900 | -0.138000 | 0.125000 | 9.11e-01 | 3.87e-01 | 4.36e-01 |
| Signaling by FGFR3 point mutants in cancer | 13 | 3.08e-01 | 3.74e-01 | 0.1870 | 0.017900 | -0.138000 | 0.125000 | 9.11e-01 | 3.87e-01 | 4.36e-01 |
| Cyclin A:Cdk2-associated events at S phase entry | 85 | 2.29e-03 | 6.08e-03 | 0.1870 | 0.159000 | 0.012500 | -0.097300 | 1.13e-02 | 8.42e-01 | 1.21e-01 |
| TP53 Regulates Transcription of Death Receptors and Ligands | 11 | 4.08e-01 | 4.73e-01 | 0.1870 | 0.159000 | -0.034900 | -0.090600 | 3.60e-01 | 8.41e-01 | 6.03e-01 |
| Class B/2 (Secretin family receptors) | 56 | 4.62e-02 | 7.71e-02 | 0.1860 | 0.020200 | 0.079500 | -0.167000 | 7.94e-01 | 3.04e-01 | 3.02e-02 |
| Metal ion SLC transporters | 21 | 7.26e-01 | 7.68e-01 | 0.1860 | 0.132000 | 0.110000 | -0.070100 | 2.94e-01 | 3.81e-01 | 5.78e-01 |
| Blood group systems biosynthesis | 17 | 5.36e-01 | 5.93e-01 | 0.1850 | 0.150000 | 0.033100 | -0.103000 | 2.84e-01 | 8.13e-01 | 4.60e-01 |
| Regulation of TP53 Activity through Phosphorylation | 88 | 7.53e-02 | 1.18e-01 | 0.1840 | -0.093500 | -0.108000 | 0.116000 | 1.30e-01 | 7.93e-02 | 5.92e-02 |
| Ion homeostasis | 40 | 1.50e-01 | 2.07e-01 | 0.1840 | 0.016400 | 0.064900 | -0.171000 | 8.58e-01 | 4.77e-01 | 6.10e-02 |
| Activation of RAC1 | 11 | 7.93e-01 | 8.23e-01 | 0.1840 | 0.161000 | 0.078500 | -0.038300 | 3.54e-01 | 6.52e-01 | 8.26e-01 |
| TCR signaling | 121 | 6.51e-04 | 2.04e-03 | 0.1830 | 0.077600 | -0.046000 | -0.160000 | 1.41e-01 | 3.82e-01 | 2.40e-03 |
| FOXO-mediated transcription of cell cycle genes | 15 | 6.82e-01 | 7.26e-01 | 0.1830 | 0.011900 | -0.011300 | -0.182000 | 9.37e-01 | 9.40e-01 | 2.22e-01 |
| Negative epigenetic regulation of rRNA expression | 65 | 6.64e-03 | 1.48e-02 | 0.1820 | 0.101000 | -0.057300 | -0.140000 | 1.57e-01 | 4.24e-01 | 5.03e-02 |
| Peptide ligand-binding receptors | 91 | 9.92e-02 | 1.48e-01 | 0.1820 | 0.108000 | 0.088400 | -0.117000 | 7.57e-02 | 1.45e-01 | 5.46e-02 |
| HATs acetylate histones | 93 | 2.75e-02 | 5.00e-02 | 0.1820 | -0.016900 | -0.039900 | -0.176000 | 7.78e-01 | 5.06e-01 | 3.29e-03 |
| CASP8 activity is inhibited | 11 | 7.46e-01 | 7.82e-01 | 0.1810 | -0.010700 | -0.028000 | 0.179000 | 9.51e-01 | 8.72e-01 | 3.05e-01 |
| Dimerization of procaspase-8 | 11 | 7.46e-01 | 7.82e-01 | 0.1810 | -0.010700 | -0.028000 | 0.179000 | 9.51e-01 | 8.72e-01 | 3.05e-01 |
| Regulation by c-FLIP | 11 | 7.46e-01 | 7.82e-01 | 0.1810 | -0.010700 | -0.028000 | 0.179000 | 9.51e-01 | 8.72e-01 | 3.05e-01 |
| Mitotic Spindle Checkpoint | 108 | 4.55e-03 | 1.08e-02 | 0.1810 | -0.032300 | -0.078900 | 0.159000 | 5.62e-01 | 1.56e-01 | 4.19e-03 |
| Synthesis of DNA | 118 | 1.69e-04 | 6.38e-04 | 0.1800 | -0.031500 | -0.174000 | -0.036000 | 5.55e-01 | 1.09e-03 | 4.99e-01 |
| EML4 and NUDC in mitotic spindle formation | 95 | 1.16e-02 | 2.38e-02 | 0.1800 | -0.020200 | -0.052500 | 0.171000 | 7.34e-01 | 3.76e-01 | 3.92e-03 |
| HIV Infection | 224 | 4.21e-07 | 3.58e-06 | 0.1790 | 0.130000 | -0.002760 | -0.123000 | 7.72e-04 | 9.43e-01 | 1.57e-03 |
| PI3K Cascade | 30 | 4.30e-01 | 4.94e-01 | 0.1790 | 0.056100 | 0.002460 | -0.170000 | 5.95e-01 | 9.81e-01 | 1.08e-01 |
| Amino acid transport across the plasma membrane | 23 | 4.77e-01 | 5.40e-01 | 0.1780 | 0.147000 | 0.043600 | -0.091100 | 2.23e-01 | 7.18e-01 | 4.50e-01 |
| Chromatin modifying enzymes | 217 | 2.46e-04 | 8.89e-04 | 0.1770 | 0.047800 | 0.041100 | -0.166000 | 2.25e-01 | 2.97e-01 | 2.64e-05 |
| Chromatin organization | 217 | 2.46e-04 | 8.89e-04 | 0.1770 | 0.047800 | 0.041100 | -0.166000 | 2.25e-01 | 2.97e-01 | 2.64e-05 |
| G alpha (i) signalling events | 241 | 1.27e-03 | 3.65e-03 | 0.1770 | 0.108000 | 0.080900 | -0.115000 | 3.93e-03 | 3.05e-02 | 2.19e-03 |
| TICAM1-dependent activation of IRF3/IRF7 | 12 | 7.63e-01 | 7.97e-01 | 0.1770 | 0.074900 | -0.000749 | -0.160000 | 6.53e-01 | 9.96e-01 | 3.37e-01 |
| TRP channels | 17 | 4.75e-01 | 5.38e-01 | 0.1760 | -0.065400 | 0.066200 | 0.150000 | 6.40e-01 | 6.37e-01 | 2.85e-01 |
| Downstream signaling of activated FGFR1 | 20 | 5.66e-01 | 6.18e-01 | 0.1760 | 0.094300 | 0.062700 | 0.135000 | 4.65e-01 | 6.27e-01 | 2.95e-01 |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 17 | 6.94e-01 | 7.37e-01 | 0.1760 | -0.082300 | -0.156000 | 0.005300 | 5.57e-01 | 2.67e-01 | 9.70e-01 |
| RNA polymerase II transcribes snRNA genes | 72 | 7.09e-02 | 1.12e-01 | 0.1750 | 0.110000 | 0.071100 | 0.116000 | 1.06e-01 | 2.97e-01 | 8.76e-02 |
| SHC-mediated cascade:FGFR1 | 12 | 8.09e-01 | 8.37e-01 | 0.1750 | 0.107000 | 0.089000 | 0.107000 | 5.21e-01 | 5.93e-01 | 5.22e-01 |
| Regulation of PTEN mRNA translation | 13 | 5.34e-01 | 5.91e-01 | 0.1750 | -0.057500 | 0.090400 | 0.139000 | 7.20e-01 | 5.72e-01 | 3.86e-01 |
| Regulation of RUNX1 Expression and Activity | 18 | 5.84e-01 | 6.34e-01 | 0.1750 | -0.072900 | 0.021300 | 0.158000 | 5.92e-01 | 8.76e-01 | 2.46e-01 |
| Cilium Assembly | 181 | 1.06e-02 | 2.24e-02 | 0.1750 | -0.101000 | -0.141000 | 0.022300 | 1.88e-02 | 1.10e-03 | 6.06e-01 |
| Fcgamma receptor (FCGR) dependent phagocytosis | 147 | 1.53e-02 | 3.04e-02 | 0.1740 | 0.145000 | 0.095500 | 0.019000 | 2.44e-03 | 4.57e-02 | 6.90e-01 |
| Cellular hexose transport | 15 | 7.75e-01 | 8.08e-01 | 0.1740 | -0.105000 | -0.095800 | -0.101000 | 4.83e-01 | 5.21e-01 | 4.97e-01 |
| Lysine catabolism | 11 | 8.65e-01 | 8.85e-01 | 0.1730 | 0.087100 | 0.138000 | 0.057500 | 6.17e-01 | 4.27e-01 | 7.41e-01 |
| Signaling by NTRK2 (TRKB) | 20 | 6.91e-01 | 7.34e-01 | 0.1730 | 0.148000 | 0.088100 | -0.006390 | 2.50e-01 | 4.95e-01 | 9.61e-01 |
| DNA Double Strand Break Response | 47 | 3.05e-01 | 3.71e-01 | 0.1720 | 0.079400 | 0.034000 | -0.149000 | 3.46e-01 | 6.87e-01 | 7.79e-02 |
| TP53 Regulates Transcription of Cell Death Genes | 42 | 1.61e-01 | 2.19e-01 | 0.1710 | 0.160000 | 0.045100 | -0.041300 | 7.29e-02 | 6.13e-01 | 6.43e-01 |
| Eicosanoid ligand-binding receptors | 13 | 7.83e-01 | 8.14e-01 | 0.1710 | -0.051500 | -0.064500 | -0.149000 | 7.48e-01 | 6.87e-01 | 3.52e-01 |
| Methylation | 12 | 7.65e-01 | 7.99e-01 | 0.1700 | -0.022700 | -0.108000 | -0.130000 | 8.92e-01 | 5.18e-01 | 4.37e-01 |
| Basigin interactions | 23 | 3.81e-01 | 4.47e-01 | 0.1690 | 0.061900 | -0.062800 | -0.144000 | 6.07e-01 | 6.02e-01 | 2.31e-01 |
| Non-integrin membrane-ECM interactions | 37 | 2.95e-01 | 3.59e-01 | 0.1690 | 0.111000 | 0.013000 | -0.127000 | 2.44e-01 | 8.91e-01 | 1.81e-01 |
| Orc1 removal from chromatin | 69 | 1.39e-03 | 3.97e-03 | 0.1690 | 0.141000 | -0.040700 | -0.084600 | 4.36e-02 | 5.58e-01 | 2.24e-01 |
| Downstream signaling of activated FGFR3 | 16 | 3.96e-01 | 4.61e-01 | 0.1690 | 0.135000 | 0.014900 | 0.100000 | 3.50e-01 | 9.18e-01 | 4.89e-01 |
| Signaling by ERBB2 ECD mutants | 15 | 5.74e-01 | 6.25e-01 | 0.1680 | 0.153000 | 0.050100 | 0.049500 | 3.06e-01 | 7.37e-01 | 7.40e-01 |
| Zinc transporters | 14 | 8.52e-01 | 8.74e-01 | 0.1680 | 0.130000 | 0.087800 | -0.058100 | 3.98e-01 | 5.70e-01 | 7.07e-01 |
| Peptide hormone metabolism | 49 | 1.27e-01 | 1.82e-01 | 0.1670 | 0.159000 | 0.050600 | -0.018600 | 5.48e-02 | 5.40e-01 | 8.22e-01 |
| Signaling by FGFR2 in disease | 32 | 1.08e-01 | 1.58e-01 | 0.1670 | 0.042500 | -0.121000 | -0.107000 | 6.77e-01 | 2.35e-01 | 2.94e-01 |
| S Phase | 160 | 3.36e-05 | 1.56e-04 | 0.1670 | -0.032200 | -0.163000 | -0.016400 | 4.82e-01 | 3.78e-04 | 7.21e-01 |
| GABA synthesis, release, reuptake and degradation | 13 | 7.94e-01 | 8.24e-01 | 0.1670 | -0.030600 | -0.065000 | -0.150000 | 8.48e-01 | 6.85e-01 | 3.48e-01 |
| Interferon gamma signaling | 83 | 1.08e-02 | 2.25e-02 | 0.1650 | -0.144000 | -0.014000 | 0.078700 | 2.32e-02 | 8.25e-01 | 2.15e-01 |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 20 | 3.95e-01 | 4.60e-01 | 0.1640 | -0.016100 | -0.153000 | -0.057500 | 9.01e-01 | 2.36e-01 | 6.56e-01 |
| SLC-mediated transmembrane transport | 179 | 2.87e-02 | 5.20e-02 | 0.1640 | 0.103000 | 0.104000 | -0.074000 | 1.72e-02 | 1.66e-02 | 8.78e-02 |
| Glycolysis | 66 | 2.30e-01 | 2.91e-01 | 0.1630 | 0.093400 | 0.046000 | -0.125000 | 1.89e-01 | 5.18e-01 | 7.85e-02 |
| SUMOylation of transcription factors | 16 | 8.34e-01 | 8.58e-01 | 0.1610 | 0.132000 | 0.087100 | -0.032300 | 3.61e-01 | 5.46e-01 | 8.23e-01 |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 23 | 7.22e-01 | 7.63e-01 | 0.1610 | 0.090900 | 0.064800 | -0.116000 | 4.50e-01 | 5.90e-01 | 3.36e-01 |
| Cell-cell junction organization | 36 | 4.13e-01 | 4.77e-01 | 0.1610 | 0.042900 | -0.018300 | -0.154000 | 6.56e-01 | 8.49e-01 | 1.10e-01 |
| DNA Replication | 125 | 1.86e-04 | 6.97e-04 | 0.1610 | -0.018700 | -0.159000 | -0.015600 | 7.17e-01 | 2.17e-03 | 7.63e-01 |
| FCGR3A-mediated phagocytosis | 121 | 1.50e-02 | 2.99e-02 | 0.1600 | 0.134000 | 0.068300 | 0.054800 | 1.08e-02 | 1.95e-01 | 2.98e-01 |
| Leishmania phagocytosis | 121 | 1.50e-02 | 2.99e-02 | 0.1600 | 0.134000 | 0.068300 | 0.054800 | 1.08e-02 | 1.95e-01 | 2.98e-01 |
| Parasite infection | 121 | 1.50e-02 | 2.99e-02 | 0.1600 | 0.134000 | 0.068300 | 0.054800 | 1.08e-02 | 1.95e-01 | 2.98e-01 |
| The phototransduction cascade | 25 | 7.35e-01 | 7.75e-01 | 0.1590 | -0.092100 | -0.130000 | -0.004970 | 4.25e-01 | 2.61e-01 | 9.66e-01 |
| Lysosphingolipid and LPA receptors | 11 | 8.12e-01 | 8.39e-01 | 0.1590 | -0.015100 | -0.003710 | -0.158000 | 9.31e-01 | 9.83e-01 | 3.63e-01 |
| Signaling by GPCR | 530 | 1.34e-06 | 9.63e-06 | 0.1590 | 0.083300 | 0.108000 | -0.081100 | 1.04e-03 | 1.96e-05 | 1.40e-03 |
| Gene expression (Transcription) | 1324 | 3.28e-12 | 5.68e-11 | 0.1590 | -0.101000 | -0.122000 | -0.014500 | 6.51e-10 | 1.06e-13 | 3.76e-01 |
| G alpha (s) signalling events | 140 | 2.90e-02 | 5.22e-02 | 0.1590 | 0.068500 | 0.131000 | 0.057800 | 1.62e-01 | 7.46e-03 | 2.38e-01 |
| CTLA4 inhibitory signaling | 21 | 5.65e-01 | 6.18e-01 | 0.1590 | -0.013900 | 0.016200 | -0.157000 | 9.12e-01 | 8.98e-01 | 2.12e-01 |
| DNA Double-Strand Break Repair | 135 | 1.01e-01 | 1.51e-01 | 0.1590 | -0.102000 | -0.102000 | 0.064800 | 4.03e-02 | 3.99e-02 | 1.94e-01 |
| Class I peroxisomal membrane protein import | 20 | 8.26e-01 | 8.49e-01 | 0.1580 | -0.122000 | -0.098800 | 0.019400 | 3.44e-01 | 4.44e-01 | 8.81e-01 |
| FRS-mediated FGFR4 signaling | 12 | 4.36e-01 | 5.00e-01 | 0.1580 | 0.158000 | -0.012500 | 0.006510 | 3.44e-01 | 9.40e-01 | 9.69e-01 |
| Metabolic disorders of biological oxidation enzymes | 23 | 7.44e-01 | 7.82e-01 | 0.1570 | 0.098200 | 0.065200 | -0.104000 | 4.15e-01 | 5.88e-01 | 3.88e-01 |
| Cytosolic sensors of pathogen-associated DNA | 62 | 2.12e-01 | 2.73e-01 | 0.1570 | 0.035500 | -0.011300 | -0.152000 | 6.29e-01 | 8.78e-01 | 3.80e-02 |
| PI-3K cascade:FGFR4 | 10 | 5.04e-01 | 5.65e-01 | 0.1560 | 0.104000 | -0.083800 | -0.081000 | 5.68e-01 | 6.46e-01 | 6.57e-01 |
| TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 18 | 7.43e-01 | 7.82e-01 | 0.1560 | -0.030100 | -0.063800 | -0.139000 | 8.25e-01 | 6.39e-01 | 3.07e-01 |
| DNA Replication Pre-Initiation | 82 | 8.31e-04 | 2.51e-03 | 0.1560 | 0.051000 | -0.122000 | -0.081800 | 4.25e-01 | 5.57e-02 | 2.00e-01 |
| Formation of Incision Complex in GG-NER | 43 | 9.93e-03 | 2.13e-02 | 0.1550 | 0.037900 | -0.142000 | 0.048100 | 6.67e-01 | 1.06e-01 | 5.85e-01 |
| Mitotic Prometaphase | 185 | 3.15e-03 | 7.93e-03 | 0.1550 | -0.049500 | -0.081300 | 0.122000 | 2.45e-01 | 5.65e-02 | 4.14e-03 |
| Cytokine Signaling in Immune system | 732 | 3.50e-07 | 3.04e-06 | 0.1550 | 0.107000 | 0.081600 | -0.076900 | 8.59e-07 | 1.70e-04 | 4.00e-04 |
| Miscellaneous transport and binding events | 20 | 4.74e-01 | 5.37e-01 | 0.1550 | 0.146000 | 0.022500 | -0.045400 | 2.57e-01 | 8.61e-01 | 7.25e-01 |
| G2/M DNA damage checkpoint | 67 | 1.37e-01 | 1.93e-01 | 0.1550 | -0.038400 | -0.075300 | 0.130000 | 5.87e-01 | 2.87e-01 | 6.65e-02 |
| Diseases of metabolism | 187 | 2.72e-03 | 7.01e-03 | 0.1550 | 0.028800 | 0.041400 | -0.146000 | 4.97e-01 | 3.29e-01 | 5.64e-04 |
| Transcriptional regulation by small RNAs | 63 | 8.19e-02 | 1.25e-01 | 0.1540 | 0.074200 | -0.036400 | -0.130000 | 3.09e-01 | 6.18e-01 | 7.41e-02 |
| Homology Directed Repair | 110 | 1.55e-01 | 2.13e-01 | 0.1540 | -0.089900 | -0.106000 | 0.064900 | 1.03e-01 | 5.38e-02 | 2.39e-01 |
| RUNX2 regulates osteoblast differentiation | 18 | 1.39e-01 | 1.94e-01 | 0.1540 | -0.066900 | 0.132000 | -0.042500 | 6.23e-01 | 3.34e-01 | 7.55e-01 |
| mRNA Capping | 29 | 1.44e-01 | 2.00e-01 | 0.1530 | 0.088700 | -0.077700 | -0.097100 | 4.09e-01 | 4.69e-01 | 3.65e-01 |
| Metabolism of folate and pterines | 16 | 7.09e-01 | 7.51e-01 | 0.1530 | 0.140000 | 0.058300 | 0.015800 | 3.31e-01 | 6.86e-01 | 9.13e-01 |
| Signaling by FGFR4 in disease | 11 | 5.71e-01 | 6.23e-01 | 0.1520 | 0.064700 | -0.051400 | 0.127000 | 7.10e-01 | 7.68e-01 | 4.66e-01 |
| Ras activation upon Ca2+ influx through NMDA receptor | 15 | 9.01e-01 | 9.14e-01 | 0.1510 | -0.109000 | -0.102000 | 0.021500 | 4.63e-01 | 4.92e-01 | 8.85e-01 |
| FRS-mediated FGFR2 signaling | 14 | 4.99e-01 | 5.61e-01 | 0.1510 | 0.014800 | -0.101000 | 0.111000 | 9.24e-01 | 5.11e-01 | 4.73e-01 |
| Generic Transcription Pathway | 1075 | 5.35e-09 | 6.33e-08 | 0.1510 | -0.102000 | -0.108000 | -0.027400 | 1.87e-08 | 2.52e-09 | 1.29e-01 |
| G1/S Transition | 130 | 3.57e-05 | 1.65e-04 | 0.1510 | 0.004980 | -0.150000 | -0.016100 | 9.22e-01 | 3.23e-03 | 7.51e-01 |
| MET activates PTK2 signaling | 15 | 5.27e-01 | 5.86e-01 | 0.1500 | 0.145000 | 0.020100 | 0.033200 | 3.32e-01 | 8.93e-01 | 8.24e-01 |
| Signaling by Retinoic Acid | 31 | 5.59e-01 | 6.12e-01 | 0.1490 | 0.029100 | -0.016800 | -0.146000 | 7.79e-01 | 8.71e-01 | 1.61e-01 |
| Regulation of TP53 Expression and Degradation | 36 | 4.79e-01 | 5.41e-01 | 0.1490 | -0.014500 | -0.076800 | -0.127000 | 8.80e-01 | 4.25e-01 | 1.89e-01 |
| GPCR downstream signalling | 488 | 3.85e-05 | 1.77e-04 | 0.1480 | 0.080200 | 0.098800 | -0.075700 | 2.41e-03 | 1.85e-04 | 4.19e-03 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 31 | 5.62e-01 | 6.15e-01 | 0.1480 | 0.006040 | -0.040900 | -0.142000 | 9.54e-01 | 6.94e-01 | 1.72e-01 |
| Phosphorylation of the APC/C | 20 | 1.71e-01 | 2.32e-01 | 0.1470 | 0.044700 | -0.130000 | 0.054500 | 7.29e-01 | 3.16e-01 | 6.73e-01 |
| Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) | 10 | 7.87e-01 | 8.18e-01 | 0.1470 | -0.085400 | 0.028900 | 0.117000 | 6.40e-01 | 8.74e-01 | 5.24e-01 |
| Downstream signaling of activated FGFR2 | 19 | 4.42e-01 | 5.04e-01 | 0.1470 | 0.015700 | -0.079300 | 0.123000 | 9.05e-01 | 5.50e-01 | 3.53e-01 |
| Regulation of TNFR1 signaling | 32 | 5.74e-01 | 6.25e-01 | 0.1470 | -0.110000 | -0.071100 | -0.067400 | 2.82e-01 | 4.86e-01 | 5.10e-01 |
| mRNA 3'-end processing | 56 | 1.85e-01 | 2.45e-01 | 0.1470 | -0.038500 | -0.134000 | -0.047300 | 6.19e-01 | 8.29e-02 | 5.40e-01 |
| Ca2+ pathway | 57 | 5.42e-01 | 5.98e-01 | 0.1470 | 0.109000 | 0.092500 | -0.034200 | 1.54e-01 | 2.27e-01 | 6.56e-01 |
| Prolactin receptor signaling | 11 | 5.48e-01 | 6.03e-01 | 0.1470 | 0.082400 | -0.045000 | 0.113000 | 6.36e-01 | 7.96e-01 | 5.15e-01 |
| Regulation of TP53 Activity | 151 | 1.29e-01 | 1.84e-01 | 0.1470 | -0.098500 | -0.107000 | -0.019700 | 3.67e-02 | 2.35e-02 | 6.77e-01 |
| Cytochrome P450 - arranged by substrate type | 33 | 7.27e-01 | 7.68e-01 | 0.1460 | 0.098600 | 0.085600 | -0.066100 | 3.27e-01 | 3.95e-01 | 5.11e-01 |
| DAP12 signaling | 28 | 5.04e-01 | 5.66e-01 | 0.1460 | 0.041800 | 0.104000 | -0.093200 | 7.02e-01 | 3.40e-01 | 3.93e-01 |
| Ion transport by P-type ATPases | 42 | 4.17e-01 | 4.81e-01 | 0.1460 | 0.061100 | 0.123000 | -0.046800 | 4.93e-01 | 1.66e-01 | 6.00e-01 |
| IGF1R signaling cascade | 36 | 6.04e-01 | 6.53e-01 | 0.1430 | 0.094000 | 0.042700 | -0.098700 | 3.29e-01 | 6.58e-01 | 3.05e-01 |
| Branched-chain amino acid catabolism | 21 | 7.54e-01 | 7.90e-01 | 0.1420 | -0.056800 | -0.082600 | 0.101000 | 6.52e-01 | 5.13e-01 | 4.22e-01 |
| HIV Transcription Initiation | 45 | 2.53e-02 | 4.66e-02 | 0.1420 | 0.140000 | -0.026400 | 0.001700 | 1.05e-01 | 7.59e-01 | 9.84e-01 |
| RNA Polymerase II HIV Promoter Escape | 45 | 2.53e-02 | 4.66e-02 | 0.1420 | 0.140000 | -0.026400 | 0.001700 | 1.05e-01 | 7.59e-01 | 9.84e-01 |
| RNA Polymerase II Promoter Escape | 45 | 2.53e-02 | 4.66e-02 | 0.1420 | 0.140000 | -0.026400 | 0.001700 | 1.05e-01 | 7.59e-01 | 9.84e-01 |
| RNA Polymerase II Transcription Initiation | 45 | 2.53e-02 | 4.66e-02 | 0.1420 | 0.140000 | -0.026400 | 0.001700 | 1.05e-01 | 7.59e-01 | 9.84e-01 |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | 45 | 2.53e-02 | 4.66e-02 | 0.1420 | 0.140000 | -0.026400 | 0.001700 | 1.05e-01 | 7.59e-01 | 9.84e-01 |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 45 | 2.53e-02 | 4.66e-02 | 0.1420 | 0.140000 | -0.026400 | 0.001700 | 1.05e-01 | 7.59e-01 | 9.84e-01 |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 24 | 7.08e-01 | 7.50e-01 | 0.1410 | 0.096800 | 0.031200 | -0.098300 | 4.12e-01 | 7.91e-01 | 4.05e-01 |
| Glyoxylate metabolism and glycine degradation | 24 | 2.88e-01 | 3.53e-01 | 0.1410 | -0.001780 | -0.135000 | 0.042800 | 9.88e-01 | 2.54e-01 | 7.17e-01 |
| DNA Repair | 289 | 1.05e-02 | 2.21e-02 | 0.1410 | -0.082600 | -0.114000 | -0.005730 | 1.57e-02 | 8.29e-04 | 8.67e-01 |
| Gene Silencing by RNA | 87 | 4.36e-02 | 7.35e-02 | 0.1410 | 0.001400 | -0.104000 | -0.095300 | 9.82e-01 | 9.35e-02 | 1.24e-01 |
| Nicotinate metabolism | 25 | 2.45e-01 | 3.06e-01 | 0.1410 | -0.012400 | 0.138000 | 0.022800 | 9.15e-01 | 2.31e-01 | 8.44e-01 |
| PERK regulates gene expression | 30 | 3.70e-02 | 6.43e-02 | 0.1410 | 0.091400 | -0.104000 | 0.025200 | 3.86e-01 | 3.24e-01 | 8.11e-01 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | 23 | 8.19e-01 | 8.44e-01 | 0.1390 | 0.083000 | 0.068200 | -0.088400 | 4.91e-01 | 5.71e-01 | 4.63e-01 |
| O-linked glycosylation | 83 | 1.39e-02 | 2.80e-02 | 0.1380 | -0.057000 | 0.030300 | -0.122000 | 3.69e-01 | 6.34e-01 | 5.44e-02 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 37 | 5.88e-01 | 6.37e-01 | 0.1380 | 0.073200 | 0.022700 | -0.114000 | 4.41e-01 | 8.11e-01 | 2.29e-01 |
| IRS-related events triggered by IGF1R | 35 | 5.83e-01 | 6.33e-01 | 0.1370 | 0.082100 | 0.020200 | -0.108000 | 4.00e-01 | 8.36e-01 | 2.67e-01 |
| Switching of origins to a post-replicative state | 89 | 1.04e-03 | 3.06e-03 | 0.1370 | 0.105000 | -0.060500 | -0.063500 | 8.70e-02 | 3.24e-01 | 3.00e-01 |
| TP53 Regulates Transcription of DNA Repair Genes | 61 | 4.22e-01 | 4.85e-01 | 0.1350 | -0.049100 | -0.085500 | -0.092300 | 5.07e-01 | 2.48e-01 | 2.13e-01 |
| RNA Polymerase II Pre-transcription Events | 78 | 6.61e-02 | 1.06e-01 | 0.1350 | 0.130000 | 0.026900 | -0.023800 | 4.69e-02 | 6.81e-01 | 7.16e-01 |
| Signaling by FGFR in disease | 51 | 3.14e-01 | 3.79e-01 | 0.1350 | 0.123000 | 0.037800 | -0.039600 | 1.29e-01 | 6.40e-01 | 6.25e-01 |
| FCERI mediated NF-kB activation | 137 | 1.35e-07 | 1.27e-06 | 0.1350 | 0.106000 | -0.078400 | 0.026700 | 3.20e-02 | 1.13e-01 | 5.90e-01 |
| Epigenetic regulation of gene expression | 103 | 2.99e-02 | 5.35e-02 | 0.1350 | 0.013500 | -0.088700 | -0.100000 | 8.13e-01 | 1.20e-01 | 7.86e-02 |
| Meiotic recombination | 38 | 4.35e-01 | 4.98e-01 | 0.1340 | 0.121000 | 0.032700 | -0.047000 | 1.96e-01 | 7.27e-01 | 6.16e-01 |
| Sulfur amino acid metabolism | 22 | 7.45e-01 | 7.82e-01 | 0.1340 | 0.038200 | -0.015700 | -0.127000 | 7.56e-01 | 8.99e-01 | 3.01e-01 |
| Ovarian tumor domain proteases | 37 | 6.68e-01 | 7.13e-01 | 0.1340 | 0.070700 | 0.111000 | -0.025200 | 4.57e-01 | 2.44e-01 | 7.91e-01 |
| Fc epsilon receptor (FCERI) signaling | 190 | 3.08e-06 | 2.00e-05 | 0.1340 | 0.133000 | -0.007600 | -0.011400 | 1.57e-03 | 8.57e-01 | 7.86e-01 |
| Regulation of pyruvate dehydrogenase (PDH) complex | 15 | 5.87e-01 | 6.36e-01 | 0.1340 | 0.111000 | 0.005440 | 0.075000 | 4.59e-01 | 9.71e-01 | 6.15e-01 |
| RNA Polymerase II Transcription | 1194 | 7.00e-08 | 7.00e-07 | 0.1340 | -0.085600 | -0.101000 | -0.017100 | 6.32e-07 | 4.07e-09 | 3.21e-01 |
| Antigen processing: Ubiquitination & Proteasome degradation | 287 | 6.36e-03 | 1.43e-02 | 0.1330 | 0.112000 | 0.059500 | -0.041200 | 1.15e-03 | 8.29e-02 | 2.30e-01 |
| Diseases of glycosylation | 108 | 5.25e-02 | 8.69e-02 | 0.1330 | -0.016300 | 0.015100 | -0.131000 | 7.69e-01 | 7.87e-01 | 1.89e-02 |
| Regulation of TP53 Degradation | 35 | 5.34e-01 | 5.91e-01 | 0.1320 | 0.004450 | -0.066900 | -0.114000 | 9.64e-01 | 4.93e-01 | 2.43e-01 |
| Mitotic Prophase | 98 | 1.52e-01 | 2.10e-01 | 0.1320 | 0.118000 | 0.049700 | -0.034600 | 4.43e-02 | 3.96e-01 | 5.54e-01 |
| Biological oxidations | 133 | 1.33e-01 | 1.88e-01 | 0.1310 | 0.092500 | 0.045200 | -0.081800 | 6.55e-02 | 3.68e-01 | 1.03e-01 |
| Phase II - Conjugation of compounds | 67 | 4.62e-01 | 5.24e-01 | 0.1310 | 0.106000 | 0.074600 | 0.019400 | 1.33e-01 | 2.91e-01 | 7.84e-01 |
| HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 104 | 2.37e-01 | 2.98e-01 | 0.1300 | -0.064600 | -0.085400 | 0.074000 | 2.55e-01 | 1.32e-01 | 1.92e-01 |
| Nuclear Envelope (NE) Reassembly | 69 | 2.11e-01 | 2.71e-01 | 0.1300 | 0.116000 | 0.031800 | -0.048700 | 9.60e-02 | 6.47e-01 | 4.84e-01 |
| Class A/1 (Rhodopsin-like receptors) | 160 | 8.18e-02 | 1.25e-01 | 0.1290 | 0.055400 | 0.058200 | -0.101000 | 2.26e-01 | 2.04e-01 | 2.71e-02 |
| Mitochondrial Fatty Acid Beta-Oxidation | 36 | 5.74e-01 | 6.25e-01 | 0.1290 | 0.026400 | -0.033600 | -0.121000 | 7.84e-01 | 7.27e-01 | 2.08e-01 |
| Downstream signaling of activated FGFR4 | 17 | 4.50e-01 | 5.12e-01 | 0.1280 | 0.117000 | -0.013900 | 0.050900 | 4.05e-01 | 9.21e-01 | 7.16e-01 |
| WNT ligand biogenesis and trafficking | 21 | 8.36e-01 | 8.59e-01 | 0.1280 | 0.063300 | 0.111000 | 0.008440 | 6.16e-01 | 3.79e-01 | 9.47e-01 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | 79 | 3.68e-01 | 4.35e-01 | 0.1280 | 0.057700 | 0.061600 | -0.095600 | 3.75e-01 | 3.44e-01 | 1.42e-01 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 43 | 6.56e-01 | 7.02e-01 | 0.1270 | 0.063100 | 0.062500 | -0.091200 | 4.74e-01 | 4.78e-01 | 3.01e-01 |
| Cell surface interactions at the vascular wall | 173 | 7.13e-05 | 3.05e-04 | 0.1270 | 0.116000 | -0.018400 | -0.049200 | 8.64e-03 | 6.76e-01 | 2.64e-01 |
| SUMOylation | 165 | 9.55e-02 | 1.43e-01 | 0.1240 | -0.051700 | -0.097800 | -0.055200 | 2.52e-01 | 3.03e-02 | 2.21e-01 |
| SHC-mediated cascade:FGFR4 | 10 | 6.19e-01 | 6.68e-01 | 0.1230 | 0.117000 | -0.037700 | 0.006430 | 5.21e-01 | 8.37e-01 | 9.72e-01 |
| ATF4 activates genes in response to endoplasmic reticulum stress | 25 | 2.24e-01 | 2.85e-01 | 0.1230 | 0.036200 | -0.117000 | 0.011500 | 7.54e-01 | 3.10e-01 | 9.21e-01 |
| SUMO E3 ligases SUMOylate target proteins | 159 | 9.30e-02 | 1.40e-01 | 0.1230 | -0.043700 | -0.091500 | -0.069400 | 3.42e-01 | 4.64e-02 | 1.31e-01 |
| Anchoring of the basal body to the plasma membrane | 97 | 4.14e-01 | 4.78e-01 | 0.1220 | -0.073100 | -0.083500 | 0.051500 | 2.13e-01 | 1.55e-01 | 3.81e-01 |
| Inactivation, recovery and regulation of the phototransduction cascade | 24 | 8.18e-01 | 8.44e-01 | 0.1220 | -0.059400 | -0.106000 | 0.004440 | 6.15e-01 | 3.67e-01 | 9.70e-01 |
| Transcriptional activation of mitochondrial biogenesis | 51 | 5.88e-01 | 6.37e-01 | 0.1220 | 0.097400 | 0.047000 | -0.055900 | 2.29e-01 | 5.61e-01 | 4.90e-01 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | 73 | 3.45e-01 | 4.14e-01 | 0.1210 | 0.093500 | 0.030200 | -0.071400 | 1.67e-01 | 6.56e-01 | 2.92e-01 |
| STING mediated induction of host immune responses | 15 | 7.72e-01 | 8.05e-01 | 0.1210 | 0.088600 | -0.009600 | -0.081700 | 5.52e-01 | 9.49e-01 | 5.84e-01 |
| Processing of DNA double-strand break ends | 71 | 2.42e-01 | 3.04e-01 | 0.1210 | -0.031300 | -0.082400 | 0.082700 | 6.48e-01 | 2.30e-01 | 2.29e-01 |
| Synthesis of glycosylphosphatidylinositol (GPI) | 17 | 9.14e-01 | 9.26e-01 | 0.1190 | -0.077000 | -0.050200 | 0.076200 | 5.83e-01 | 7.20e-01 | 5.87e-01 |
| Mitotic Anaphase | 223 | 2.23e-04 | 8.17e-04 | 0.1190 | 0.116000 | 0.019600 | 0.020000 | 2.93e-03 | 6.14e-01 | 6.07e-01 |
| IRS-mediated signalling | 34 | 6.65e-01 | 7.10e-01 | 0.1180 | 0.064600 | 0.003520 | -0.099200 | 5.14e-01 | 9.72e-01 | 3.17e-01 |
| Recruitment of NuMA to mitotic centrosomes | 80 | 5.85e-01 | 6.35e-01 | 0.1180 | -0.081500 | -0.085200 | -0.011300 | 2.08e-01 | 1.88e-01 | 8.61e-01 |
| GPCR ligand binding | 226 | 1.69e-02 | 3.29e-02 | 0.1180 | 0.034000 | 0.060000 | -0.095800 | 3.78e-01 | 1.20e-01 | 1.31e-02 |
| Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 17 | 6.24e-01 | 6.72e-01 | 0.1170 | -0.029100 | 0.093000 | 0.065400 | 8.35e-01 | 5.07e-01 | 6.41e-01 |
| Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 17 | 6.24e-01 | 6.72e-01 | 0.1170 | -0.029100 | 0.093000 | 0.065400 | 8.35e-01 | 5.07e-01 | 6.41e-01 |
| Visual phototransduction | 58 | 5.27e-01 | 5.86e-01 | 0.1160 | 0.032600 | 0.029800 | -0.108000 | 6.68e-01 | 6.94e-01 | 1.57e-01 |
| Signaling by NTRK3 (TRKC) | 16 | 8.17e-01 | 8.43e-01 | 0.1160 | 0.072000 | -0.009820 | -0.090700 | 6.18e-01 | 9.46e-01 | 5.30e-01 |
| Receptor-type tyrosine-protein phosphatases | 12 | 9.31e-01 | 9.41e-01 | 0.1160 | 0.057000 | 0.016800 | -0.099800 | 7.32e-01 | 9.20e-01 | 5.49e-01 |
| NCAM signaling for neurite out-growth | 43 | 7.77e-01 | 8.09e-01 | 0.1160 | -0.087700 | -0.074000 | -0.016400 | 3.20e-01 | 4.01e-01 | 8.52e-01 |
| Mitotic Metaphase and Anaphase | 224 | 2.39e-04 | 8.68e-04 | 0.1150 | 0.111000 | 0.015300 | 0.024300 | 4.23e-03 | 6.93e-01 | 5.32e-01 |
| PI-3K cascade:FGFR1 | 12 | 9.18e-01 | 9.30e-01 | 0.1140 | 0.096200 | 0.050600 | 0.033900 | 5.64e-01 | 7.61e-01 | 8.39e-01 |
| DDX58/IFIH1-mediated induction of interferon-alpha/beta | 63 | 6.50e-01 | 6.97e-01 | 0.1130 | 0.065900 | 0.070700 | -0.059000 | 3.66e-01 | 3.32e-01 | 4.18e-01 |
| Post-translational modification: synthesis of GPI-anchored proteins | 57 | 6.53e-01 | 6.99e-01 | 0.1120 | 0.060100 | 0.082200 | -0.047100 | 4.33e-01 | 2.83e-01 | 5.39e-01 |
| Nucleotide-like (purinergic) receptors | 12 | 8.71e-01 | 8.91e-01 | 0.1120 | 0.091300 | 0.005720 | -0.064700 | 5.84e-01 | 9.73e-01 | 6.98e-01 |
| Centrosome maturation | 81 | 6.34e-01 | 6.81e-01 | 0.1110 | -0.077500 | -0.079600 | -0.005840 | 2.28e-01 | 2.16e-01 | 9.28e-01 |
| Recruitment of mitotic centrosome proteins and complexes | 81 | 6.34e-01 | 6.81e-01 | 0.1110 | -0.077500 | -0.079600 | -0.005840 | 2.28e-01 | 2.16e-01 | 9.28e-01 |
| Separation of Sister Chromatids | 167 | 4.89e-04 | 1.61e-03 | 0.1110 | 0.096200 | -0.007680 | 0.053900 | 3.19e-02 | 8.64e-01 | 2.29e-01 |
| TP53 Regulates Transcription of Caspase Activators and Caspases | 11 | 7.61e-01 | 7.96e-01 | 0.1100 | 0.009810 | -0.110000 | -0.007850 | 9.55e-01 | 5.29e-01 | 9.64e-01 |
| SLC transporter disorders | 75 | 3.89e-01 | 4.55e-01 | 0.1090 | -0.004470 | -0.059400 | -0.091100 | 9.47e-01 | 3.74e-01 | 1.72e-01 |
| Processing of Intronless Pre-mRNAs | 19 | 8.97e-01 | 9.12e-01 | 0.1090 | -0.084900 | -0.037400 | 0.056300 | 5.22e-01 | 7.78e-01 | 6.71e-01 |
| Adaptive Immune System | 755 | 6.08e-04 | 1.94e-03 | 0.1070 | 0.070700 | 0.048800 | -0.063400 | 9.45e-04 | 2.26e-02 | 3.04e-03 |
| Cardiac conduction | 91 | 1.08e-01 | 1.58e-01 | 0.1060 | 0.018100 | 0.104000 | -0.012700 | 7.66e-01 | 8.60e-02 | 8.34e-01 |
| Cell Cycle Checkpoints | 258 | 1.10e-04 | 4.45e-04 | 0.1050 | 0.015300 | -0.063300 | 0.082800 | 6.71e-01 | 8.02e-02 | 2.20e-02 |
| Organelle biogenesis and maintenance | 269 | 2.29e-03 | 6.07e-03 | 0.1050 | -0.014100 | -0.095600 | -0.040200 | 6.90e-01 | 6.97e-03 | 2.56e-01 |
| Acyl chain remodelling of PS | 14 | 9.28e-01 | 9.39e-01 | 0.1050 | 0.089300 | 0.036200 | -0.040400 | 5.63e-01 | 8.15e-01 | 7.93e-01 |
| TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 14 | 9.01e-01 | 9.14e-01 | 0.1040 | 0.019200 | 0.000809 | 0.103000 | 9.01e-01 | 9.96e-01 | 5.06e-01 |
| Phase 2 - plateau phase | 17 | 7.32e-01 | 7.72e-01 | 0.1040 | -0.089100 | 0.014200 | 0.051800 | 5.25e-01 | 9.19e-01 | 7.12e-01 |
| Signaling by the B Cell Receptor (BCR) | 162 | 5.23e-05 | 2.33e-04 | 0.1020 | 0.087200 | -0.053400 | -0.003980 | 5.54e-02 | 2.41e-01 | 9.30e-01 |
| Deposition of new CENPA-containing nucleosomes at the centromere | 40 | 2.62e-01 | 3.26e-01 | 0.1020 | 0.022200 | -0.097100 | -0.022700 | 8.08e-01 | 2.88e-01 | 8.04e-01 |
| Nucleosome assembly | 40 | 2.62e-01 | 3.26e-01 | 0.1020 | 0.022200 | -0.097100 | -0.022700 | 8.08e-01 | 2.88e-01 | 8.04e-01 |
| Nonhomologous End-Joining (NHEJ) | 42 | 7.55e-01 | 7.90e-01 | 0.1020 | 0.085300 | 0.050600 | 0.021700 | 3.39e-01 | 5.70e-01 | 8.08e-01 |
| Mitotic G1 phase and G1/S transition | 148 | 7.86e-04 | 2.40e-03 | 0.1000 | 0.032400 | -0.094500 | -0.008510 | 4.96e-01 | 4.72e-02 | 8.58e-01 |
| Netrin-1 signaling | 40 | 8.09e-01 | 8.36e-01 | 0.0980 | 0.042200 | 0.045200 | -0.076000 | 6.44e-01 | 6.21e-01 | 4.06e-01 |
| RHO GTPases Activate Formins | 117 | 2.91e-01 | 3.56e-01 | 0.0969 | 0.018600 | 0.010800 | 0.094500 | 7.29e-01 | 8.39e-01 | 7.75e-02 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 13 | 8.42e-01 | 8.64e-01 | 0.0967 | 0.005520 | -0.063100 | 0.073100 | 9.73e-01 | 6.94e-01 | 6.48e-01 |
| Transcription of the HIV genome | 67 | 1.29e-01 | 1.84e-01 | 0.0954 | 0.083400 | -0.028000 | -0.037000 | 2.38e-01 | 6.91e-01 | 6.00e-01 |
| Glutamate Neurotransmitter Release Cycle | 20 | 8.82e-01 | 8.97e-01 | 0.0953 | -0.041700 | -0.022300 | -0.082700 | 7.47e-01 | 8.63e-01 | 5.22e-01 |
| Aberrant regulation of mitotic exit in cancer due to RB1 defects | 20 | 6.17e-01 | 6.66e-01 | 0.0952 | 0.013900 | -0.091000 | 0.024300 | 9.14e-01 | 4.81e-01 | 8.51e-01 |
| HIV Life Cycle | 144 | 1.03e-02 | 2.18e-02 | 0.0945 | 0.045100 | -0.063500 | -0.053600 | 3.50e-01 | 1.88e-01 | 2.67e-01 |
| Glutathione synthesis and recycling | 10 | 9.69e-01 | 9.74e-01 | 0.0908 | -0.001390 | -0.032500 | -0.084800 | 9.94e-01 | 8.59e-01 | 6.43e-01 |
| M Phase | 360 | 6.88e-04 | 2.14e-03 | 0.0895 | 0.088100 | 0.015100 | 0.004530 | 4.10e-03 | 6.23e-01 | 8.83e-01 |
| Mitotic G2-G2/M phases | 181 | 1.56e-02 | 3.09e-02 | 0.0878 | 0.086700 | 0.005320 | 0.012900 | 4.42e-02 | 9.02e-01 | 7.65e-01 |
| CLEC7A (Dectin-1) induces NFAT activation | 11 | 9.72e-01 | 9.76e-01 | 0.0878 | -0.035300 | -0.073700 | -0.032100 | 8.39e-01 | 6.72e-01 | 8.54e-01 |
| HCMV Early Events | 74 | 1.95e-01 | 2.57e-01 | 0.0867 | 0.017400 | -0.078400 | -0.032700 | 7.96e-01 | 2.43e-01 | 6.27e-01 |
| PKMTs methylate histone lysines | 44 | 7.60e-01 | 7.95e-01 | 0.0841 | -0.072600 | -0.019200 | 0.038000 | 4.05e-01 | 8.26e-01 | 6.63e-01 |
| Late Phase of HIV Life Cycle | 131 | 3.86e-02 | 6.63e-02 | 0.0818 | 0.061900 | -0.036400 | -0.039300 | 2.21e-01 | 4.72e-01 | 4.38e-01 |
| G2/M Checkpoints | 138 | 5.39e-03 | 1.24e-02 | 0.0803 | 0.054000 | -0.058400 | 0.011000 | 2.74e-01 | 2.36e-01 | 8.23e-01 |
| G2/M Transition | 179 | 2.12e-02 | 4.03e-02 | 0.0799 | 0.079500 | -0.002450 | 0.007480 | 6.65e-02 | 9.55e-01 | 8.63e-01 |
| Transcriptional Regulation by TP53 | 350 | 1.02e-02 | 2.17e-02 | 0.0782 | 0.041100 | -0.024200 | -0.062000 | 1.87e-01 | 4.37e-01 | 4.63e-02 |
| Cyclin D associated events in G1 | 47 | 8.79e-01 | 8.95e-01 | 0.0779 | 0.066000 | 0.041300 | 0.001640 | 4.34e-01 | 6.24e-01 | 9.85e-01 |
| G1 Phase | 47 | 8.79e-01 | 8.95e-01 | 0.0779 | 0.066000 | 0.041300 | 0.001640 | 4.34e-01 | 6.24e-01 | 9.85e-01 |
| Cell Cycle | 623 | 6.77e-05 | 2.91e-04 | 0.0767 | -0.009680 | -0.066500 | 0.037000 | 6.80e-01 | 4.60e-03 | 1.15e-01 |
| Loss of Nlp from mitotic centrosomes | 69 | 8.74e-01 | 8.91e-01 | 0.0761 | -0.055300 | -0.047300 | 0.022200 | 4.27e-01 | 4.97e-01 | 7.49e-01 |
| Loss of proteins required for interphase microtubule organization from the centrosome | 69 | 8.74e-01 | 8.91e-01 | 0.0761 | -0.055300 | -0.047300 | 0.022200 | 4.27e-01 | 4.97e-01 | 7.49e-01 |
| Cargo trafficking to the periciliary membrane | 47 | 2.94e-01 | 3.59e-01 | 0.0750 | 0.048100 | -0.053100 | 0.022000 | 5.68e-01 | 5.29e-01 | 7.94e-01 |
| Transcriptional Regulation by VENTX | 38 | 8.62e-01 | 8.82e-01 | 0.0746 | -0.058800 | -0.029800 | -0.034900 | 5.30e-01 | 7.50e-01 | 7.10e-01 |
| Metabolism of vitamins and cofactors | 155 | 5.57e-01 | 6.11e-01 | 0.0744 | 0.037600 | 0.053300 | -0.035900 | 4.20e-01 | 2.52e-01 | 4.41e-01 |
| Diseases associated with N-glycosylation of proteins | 17 | 8.03e-01 | 8.32e-01 | 0.0724 | 0.054600 | -0.038900 | -0.027300 | 6.96e-01 | 7.81e-01 | 8.46e-01 |
| TP53 Regulates Transcription of Cell Cycle Genes | 47 | 3.26e-01 | 3.93e-01 | 0.0723 | 0.047400 | -0.050300 | 0.021400 | 5.74e-01 | 5.51e-01 | 8.00e-01 |
| Negative regulators of DDX58/IFIH1 signaling | 34 | 8.54e-01 | 8.75e-01 | 0.0673 | -0.014100 | -0.065400 | -0.007560 | 8.87e-01 | 5.09e-01 | 9.39e-01 |
| TNF signaling | 42 | 9.01e-01 | 9.14e-01 | 0.0646 | 0.010600 | 0.018000 | -0.061200 | 9.06e-01 | 8.40e-01 | 4.93e-01 |
| Regulation of PLK1 Activity at G2/M Transition | 87 | 6.87e-01 | 7.30e-01 | 0.0621 | -0.017700 | -0.053000 | 0.027000 | 7.75e-01 | 3.93e-01 | 6.64e-01 |
| Aberrant regulation of mitotic cell cycle due to RB1 defects | 36 | 9.61e-01 | 9.67e-01 | 0.0605 | -0.031800 | -0.030400 | 0.041600 | 7.41e-01 | 7.52e-01 | 6.66e-01 |
| Diseases of mitotic cell cycle | 36 | 9.61e-01 | 9.67e-01 | 0.0605 | -0.031800 | -0.030400 | 0.041600 | 7.41e-01 | 7.52e-01 | 6.66e-01 |
| AURKA Activation by TPX2 | 72 | 9.31e-01 | 9.41e-01 | 0.0564 | -0.036500 | -0.030800 | 0.029900 | 5.92e-01 | 6.51e-01 | 6.61e-01 |
| Cell Cycle, Mitotic | 501 | 5.21e-04 | 1.69e-03 | 0.0561 | 0.018800 | -0.045700 | 0.026600 | 4.71e-01 | 8.00e-02 | 3.09e-01 |
| TNFR1-induced NFkappaB signaling pathway | 25 | 9.57e-01 | 9.64e-01 | 0.0525 | -0.037300 | 0.001940 | 0.036900 | 7.47e-01 | 9.87e-01 | 7.49e-01 |
| Neurotransmitter release cycle | 37 | 9.72e-01 | 9.76e-01 | 0.0489 | 0.022800 | 0.034300 | -0.026500 | 8.11e-01 | 7.18e-01 | 7.80e-01 |
| Signaling by BMP | 21 | 9.85e-01 | 9.88e-01 | 0.0485 | -0.019100 | -0.043700 | -0.009260 | 8.80e-01 | 7.29e-01 | 9.41e-01 |
| Reproduction | 80 | 7.76e-01 | 8.08e-01 | 0.0472 | 0.043300 | 0.000175 | -0.018900 | 5.03e-01 | 9.98e-01 | 7.70e-01 |
| Interleukin-35 Signalling | 12 | 9.96e-01 | 9.96e-01 | 0.0462 | -0.022900 | -0.034900 | 0.019900 | 8.91e-01 | 8.34e-01 | 9.05e-01 |
| TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | 13 | 9.52e-01 | 9.60e-01 | 0.0448 | 0.031000 | -0.025000 | 0.020400 | 8.47e-01 | 8.76e-01 | 8.98e-01 |
| IL-6-type cytokine receptor ligand interactions | 12 | 9.94e-01 | 9.95e-01 | 0.0416 | 0.038800 | 0.014600 | 0.002360 | 8.16e-01 | 9.30e-01 | 9.89e-01 |
| Signaling by KIT in disease | 20 | 9.49e-01 | 9.58e-01 | 0.0415 | -0.040100 | 0.009590 | 0.005120 | 7.56e-01 | 9.41e-01 | 9.68e-01 |
| Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants | 20 | 9.49e-01 | 9.58e-01 | 0.0415 | -0.040100 | 0.009590 | 0.005120 | 7.56e-01 | 9.41e-01 | 9.68e-01 |
| Meiosis | 68 | 8.02e-01 | 8.31e-01 | 0.0381 | 0.036200 | -0.005620 | 0.010500 | 6.05e-01 | 9.36e-01 | 8.81e-01 |
| Synthesis of PA | 32 | 9.91e-01 | 9.93e-01 | 0.0371 | 0.018900 | 0.025300 | -0.019400 | 8.54e-01 | 8.04e-01 | 8.49e-01 |
| Metabolism of water-soluble vitamins and cofactors | 109 | 7.01e-01 | 7.43e-01 | 0.0325 | -0.027800 | 0.015800 | 0.005650 | 6.16e-01 | 7.75e-01 | 9.19e-01 |
| Anti-inflammatory response favouring Leishmania parasite infection | 169 | 8.73e-01 | 8.91e-01 | 0.0247 | 0.001800 | -0.022200 | -0.010500 | 9.68e-01 | 6.18e-01 | 8.13e-01 |
| Leishmania parasite growth and survival | 169 | 8.73e-01 | 8.91e-01 | 0.0247 | 0.001800 | -0.022200 | -0.010500 | 9.68e-01 | 6.18e-01 | 8.13e-01 |
| Kinesins | 39 | 9.99e-01 | 9.99e-01 | 0.0136 | 0.002780 | 0.010600 | 0.008000 | 9.76e-01 | 9.08e-01 | 9.31e-01 |
Detailed Gene set reports
IRAK4 deficiency (TLR2/4)
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 7.5e-06 |
| p.adjustMANOVA | 4.34e-05 |
| s.dist | 1.25 |
| s.t0_v_pod | 0.899 |
| s.pod_crp | 0.868 |
| s.t0_crp | -0.0598 |
| p.t0_v_pod | 8.36e-07 |
| p.pod_crp | 1.99e-06 |
| p.t0_crp | 0.743 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CD36 | 9283 | 10747 |
| TLR2 | 8950 | 10352 |
| MYD88 | 8009 | 11117 |
| TLR1 | 8782 | 9888 |
| CD14 | 8944 | 9321 |
| TLR4 | 8864 | 9402 |
| LY96 | 8649 | 9181 |
| TLR6 | 8694 | 8940 |
| BTK | 7100 | 10653 |
| TIRAP | 5571 | 8733 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BTK | 7100 | 10653 | 7751 |
| CD14 | 8944 | 9321 | -7666 |
| CD36 | 9283 | 10747 | -147 |
| LY96 | 8649 | 9181 | 4818 |
| MYD88 | 8009 | 11117 | 3555 |
| TIRAP | 5571 | 8733 | -2324 |
| TLR1 | 8782 | 9888 | 5302 |
| TLR2 | 8950 | 10352 | 3541 |
| TLR4 | 8864 | 9402 | -2478 |
| TLR6 | 8694 | 8940 | -2193 |
MyD88 deficiency (TLR2/4)
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 7.5e-06 |
| p.adjustMANOVA | 4.34e-05 |
| s.dist | 1.25 |
| s.t0_v_pod | 0.899 |
| s.pod_crp | 0.868 |
| s.t0_crp | -0.0598 |
| p.t0_v_pod | 8.36e-07 |
| p.pod_crp | 1.99e-06 |
| p.t0_crp | 0.743 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CD36 | 9283 | 10747 |
| TLR2 | 8950 | 10352 |
| MYD88 | 8009 | 11117 |
| TLR1 | 8782 | 9888 |
| CD14 | 8944 | 9321 |
| TLR4 | 8864 | 9402 |
| LY96 | 8649 | 9181 |
| TLR6 | 8694 | 8940 |
| BTK | 7100 | 10653 |
| TIRAP | 5571 | 8733 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BTK | 7100 | 10653 | 7751 |
| CD14 | 8944 | 9321 | -7666 |
| CD36 | 9283 | 10747 | -147 |
| LY96 | 8649 | 9181 | 4818 |
| MYD88 | 8009 | 11117 | 3555 |
| TIRAP | 5571 | 8733 | -2324 |
| TLR1 | 8782 | 9888 | 5302 |
| TLR2 | 8950 | 10352 | 3541 |
| TLR4 | 8864 | 9402 | -2478 |
| TLR6 | 8694 | 8940 | -2193 |
Peptide chain elongation
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 9.12e-75 |
| p.adjustMANOVA | 1.24e-72 |
| s.dist | 1.15 |
| s.t0_v_pod | -0.281 |
| s.pod_crp | -0.769 |
| s.t0_crp | -0.811 |
| p.t0_v_pod | 5.05e-06 |
| p.pod_crp | 7.95e-36 |
| p.t0_crp | 1.13e-39 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| EEF1A1 | -8179 | -9723 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EEF1A1 | -4918 | -9723 | -8179 |
| EEF2 | 304 | -6254 | -8868 |
| FAU | -359 | -3599 | -8841 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Eukaryotic Translation Elongation
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 8.41e-79 |
| p.adjustMANOVA | 1.91e-76 |
| s.dist | 1.15 |
| s.t0_v_pod | -0.273 |
| s.pod_crp | -0.765 |
| s.t0_crp | -0.809 |
| p.t0_v_pod | 5.39e-06 |
| p.pod_crp | 2.35e-37 |
| p.t0_crp | 1.2e-41 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| EEF1B2 | -8820 | -9704 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| EEF1G | -8936 | -9265 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| EEF1A1 | -8179 | -9723 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EEF1A1 | -4918 | -9723 | -8179 |
| EEF1A1P5 | -1889 | -5853 | -5320 |
| EEF1A2 | -4993 | -3227 | -1157 |
| EEF1B2 | -4128 | -9704 | -8820 |
| EEF1D | -805 | -5640 | -8673 |
| EEF1G | -1364 | -9265 | -8936 |
| EEF2 | 304 | -6254 | -8868 |
| FAU | -359 | -3599 | -8841 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Viral mRNA Translation
| metric | value |
|---|---|
| setSize | 88 |
| pMANOVA | 9.81e-71 |
| p.adjustMANOVA | 1.03e-68 |
| s.dist | 1.11 |
| s.t0_v_pod | -0.262 |
| s.pod_crp | -0.745 |
| s.t0_crp | -0.787 |
| p.t0_v_pod | 2.13e-05 |
| p.pod_crp | 1.06e-33 |
| p.t0_crp | 2.15e-37 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DNAJC3 | 8302 | 9670 | 4528 |
| FAU | -359 | -3599 | -8841 |
| GRSF1 | 5110 | -2905 | 1530 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Selenocysteine synthesis
| metric | value |
|---|---|
| setSize | 92 |
| pMANOVA | 9.1e-70 |
| p.adjustMANOVA | 8.25e-68 |
| s.dist | 1.1 |
| s.t0_v_pod | -0.299 |
| s.pod_crp | -0.748 |
| s.t0_crp | -0.756 |
| p.t0_v_pod | 7.43e-07 |
| p.pod_crp | 2.21e-35 |
| p.t0_crp | 3.66e-36 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EEFSEC | -9700 | -6468 | -2666 |
| FAU | -359 | -3599 | -8841 |
| PSTK | -9857 | -5686 | 3544 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SARS1 | -5712 | -6019 | -7676 |
| SECISBP2 | -9999 | -6967 | 10570 |
| SEPHS2 | 7535 | 7977 | -4587 |
| SEPSECS | -10939 | -7931 | 10064 |
| UBA52 | 1112 | -3471 | -8207 |
Formation of a pool of free 40S subunits
| metric | value |
|---|---|
| setSize | 100 |
| pMANOVA | 9.21e-83 |
| p.adjustMANOVA | 3.13e-80 |
| s.dist | 1.09 |
| s.t0_v_pod | -0.208 |
| s.pod_crp | -0.743 |
| s.t0_crp | -0.769 |
| p.t0_v_pod | 0.000327 |
| p.pod_crp | 7.09e-38 |
| p.t0_crp | 1.81e-40 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| FAU | -359 | -3599 | -8841 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Eukaryotic Translation Termination
| metric | value |
|---|---|
| setSize | 92 |
| pMANOVA | 4.2e-70 |
| p.adjustMANOVA | 4.08e-68 |
| s.dist | 1.09 |
| s.t0_v_pod | -0.265 |
| s.pod_crp | -0.732 |
| s.t0_crp | -0.762 |
| p.t0_v_pod | 1.13e-05 |
| p.pod_crp | 5.45e-34 |
| p.t0_crp | 9.76e-37 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| APEH | 989 | 4901 | -7164 |
| ETF1 | 7308 | 6760 | 4048 |
| FAU | -359 | -3599 | -8841 |
| GSPT1 | 6387 | -2011 | 8737 |
| GSPT2 | -10067 | -7968 | 1941 |
| N6AMT1 | -10964 | -9254 | 4209 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| TRMT112 | 732 | -2281 | -8647 |
| UBA52 | 1112 | -3471 | -8207 |
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 3.03e-05 |
| p.adjustMANOVA | 0.000142 |
| s.dist | 1.08 |
| s.t0_v_pod | 0.785 |
| s.pod_crp | 0.726 |
| s.t0_crp | -0.133 |
| p.t0_v_pod | 2.48e-06 |
| p.pod_crp | 1.34e-05 |
| p.t0_crp | 0.424 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| ACSL1 | 9060 | 10895 |
| ACAA1 | 8162 | 10869 |
| ACOX1 | 8711 | 10100 |
| ACOT8 | 7896 | 10626 |
| FADS1 | 7583 | 10674 |
| ELOVL3 | 8568 | 9406 |
| HSD17B4 | 8710 | 8815 |
| ELOVL1 | 6984 | 9678 |
| ABCD1 | 7236 | 7891 |
| ELOVL5 | 5930 | 5610 |
| FADS2 | 1476 | 7129 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ABCD1 | 7236 | 7891 | -8401 |
| ACAA1 | 8162 | 10869 | -5822 |
| ACOT8 | 7896 | 10626 | -2931 |
| ACOX1 | 8711 | 10100 | 4567 |
| ACSL1 | 9060 | 10895 | -693 |
| ELOVL1 | 6984 | 9678 | -5255 |
| ELOVL3 | 8568 | 9406 | 7376 |
| ELOVL5 | 5930 | 5610 | 3658 |
| FADS1 | 7583 | 10674 | 8374 |
| FADS2 | 1476 | 7129 | 836 |
| HSD17B4 | 8710 | 8815 | -875 |
| SCP2 | 4410 | -1967 | 1940 |
alpha-linolenic acid (ALA) metabolism
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 3.03e-05 |
| p.adjustMANOVA | 0.000142 |
| s.dist | 1.08 |
| s.t0_v_pod | 0.785 |
| s.pod_crp | 0.726 |
| s.t0_crp | -0.133 |
| p.t0_v_pod | 2.48e-06 |
| p.pod_crp | 1.34e-05 |
| p.t0_crp | 0.424 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| ACSL1 | 9060 | 10895 |
| ACAA1 | 8162 | 10869 |
| ACOX1 | 8711 | 10100 |
| ACOT8 | 7896 | 10626 |
| FADS1 | 7583 | 10674 |
| ELOVL3 | 8568 | 9406 |
| HSD17B4 | 8710 | 8815 |
| ELOVL1 | 6984 | 9678 |
| ABCD1 | 7236 | 7891 |
| ELOVL5 | 5930 | 5610 |
| FADS2 | 1476 | 7129 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ABCD1 | 7236 | 7891 | -8401 |
| ACAA1 | 8162 | 10869 | -5822 |
| ACOT8 | 7896 | 10626 | -2931 |
| ACOX1 | 8711 | 10100 | 4567 |
| ACSL1 | 9060 | 10895 | -693 |
| ELOVL1 | 6984 | 9678 | -5255 |
| ELOVL3 | 8568 | 9406 | 7376 |
| ELOVL5 | 5930 | 5610 | 3658 |
| FADS1 | 7583 | 10674 | 8374 |
| FADS2 | 1476 | 7129 | 836 |
| HSD17B4 | 8710 | 8815 | -875 |
| SCP2 | 4410 | -1967 | 1940 |
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 2.04e-05 |
| p.adjustMANOVA | 1e-04 |
| s.dist | 1.08 |
| s.t0_v_pod | 0.67 |
| s.pod_crp | 0.664 |
| s.t0_crp | -0.516 |
| p.t0_v_pod | 0.000119 |
| p.pod_crp | 0.000136 |
| p.t0_crp | 0.00304 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| FZD5 | 9350 | 11220 |
| CLTC | 8849 | 10126 |
| AP2A1 | 6737 | 11125 |
| AP2M1 | 8486 | 8674 |
| AP2A2 | 7150 | 10047 |
| AP2S1 | 7903 | 7940 |
| CLTA | 8244 | 7078 |
| CLTB | 6002 | 7866 |
| FZD2 | 6374 | 5069 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AP2A1 | 6737 | 11125 | -6175 |
| AP2A2 | 7150 | 10047 | -6585 |
| AP2B1 | -2641 | 2884 | -1439 |
| AP2M1 | 8486 | 8674 | -8821 |
| AP2S1 | 7903 | 7940 | -7630 |
| CLTA | 8244 | 7078 | -5807 |
| CLTB | 6002 | 7866 | -8646 |
| CLTC | 8849 | 10126 | -1573 |
| FZD2 | 6374 | 5069 | -7468 |
| FZD5 | 9350 | 11220 | 2739 |
| ROR1 | -2323 | 2176 | 8962 |
Hyaluronan uptake and degradation
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00014 |
| p.adjustMANOVA | 0.000548 |
| s.dist | 1.04 |
| s.t0_v_pod | 0.729 |
| s.pod_crp | 0.574 |
| s.t0_crp | -0.471 |
| p.t0_v_pod | 6.53e-05 |
| p.pod_crp | 0.00166 |
| p.t0_crp | 0.0099 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| HYAL2 | 8935 | 11003 |
| CHP1 | 9101 | 9868 |
| SLC9A1 | 7847 | 11135 |
| GUSB | 7607 | 10966 |
| CD44 | 8201 | 9117 |
| HEXB | 8631 | 7597 |
| HYAL1 | 4123 | 8255 |
| HMMR | 3770 | 1842 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CD44 | 8201 | 9117 | -5995 |
| CHP1 | 9101 | 9868 | -5812 |
| GUSB | 7607 | 10966 | -6245 |
| HEXA | 1251 | -1954 | -6759 |
| HEXB | 8631 | 7597 | -3321 |
| HMMR | 3770 | 1842 | 1914 |
| HYAL1 | 4123 | 8255 | 9608 |
| HYAL2 | 8935 | 11003 | -8015 |
| HYAL3 | 5168 | -884 | -3394 |
| SLC9A1 | 7847 | 11135 | -5759 |
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
| metric | value |
|---|---|
| setSize | 94 |
| pMANOVA | 3.19e-66 |
| p.adjustMANOVA | 2.55e-64 |
| s.dist | 1.04 |
| s.t0_v_pod | -0.244 |
| s.pod_crp | -0.705 |
| s.t0_crp | -0.724 |
| p.t0_v_pod | 4.23e-05 |
| p.pod_crp | 2.6e-32 |
| p.t0_crp | 6.14e-34 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF4G1 | 7908 | 10325 | -6629 |
| ETF1 | 7308 | 6760 | 4048 |
| FAU | -359 | -3599 | -8841 |
| GSPT1 | 6387 | -2011 | 8737 |
| GSPT2 | -10067 | -7968 | 1941 |
| NCBP1 | -5659 | -933 | 11205 |
| NCBP2 | -9239 | -9603 | 10774 |
| PABPC1 | 5290 | -2972 | 2666 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
| UPF1 | 4629 | 8973 | -3684 |
Translocation of ZAP-70 to Immunological synapse
| metric | value |
|---|---|
| setSize | 24 |
| pMANOVA | 1.27e-09 |
| p.adjustMANOVA | 1.62e-08 |
| s.dist | 1.03 |
| s.t0_v_pod | -0.743 |
| s.pod_crp | -0.705 |
| s.t0_crp | -0.0817 |
| p.t0_v_pod | 2.86e-10 |
| p.pod_crp | 2.27e-09 |
| p.t0_crp | 0.489 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| LCK | -11482 | -9528 |
| TRBC1 | -11646 | -9275 |
| TRAC | -11130 | -9675 |
| HLA-DRA | -11649 | -8978 |
| CD247 | -11982 | -8713 |
| ZAP70 | -11590 | -8727 |
| CD3E | -10952 | -9221 |
| TRBV12-3 | -10099 | -9942 |
| HLA-DPB1 | -11887 | -8370 |
| HLA-DPA1 | -11954 | -8190 |
| CD3D | -11049 | -8270 |
| CD3G | -11173 | -8084 |
| TRAV19 | -9587 | -9220 |
| HLA-DQB2 | -9085 | -9628 |
| TRAV29DV5 | -9353 | -9250 |
| TRBV7-9 | -9220 | -8276 |
| HLA-DQA1 | -11633 | -6364 |
| HLA-DQA2 | -4652 | -8746 |
| CD4 | -5228 | -6856 |
| TRAV8-4 | -7010 | -4747 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CD247 | -11982 | -8713 | -6364 |
| CD3D | -11049 | -8270 | 2178 |
| CD3E | -10952 | -9221 | 5038 |
| CD3G | -11173 | -8084 | 8697 |
| CD4 | -5228 | -6856 | -6272 |
| HLA-DPA1 | -11954 | -8190 | 4347 |
| HLA-DPB1 | -11887 | -8370 | -2273 |
| HLA-DQA1 | -11633 | -6364 | 10152 |
| HLA-DQA2 | -4652 | -8746 | -8618 |
| HLA-DQB1 | -6199 | -4437 | 3070 |
| HLA-DQB2 | -9085 | -9628 | -6796 |
| HLA-DRA | -11649 | -8978 | 726 |
| HLA-DRB1 | -7792 | -330 | 8671 |
| HLA-DRB5 | -4806 | 741 | 5896 |
| LCK | -11482 | -9528 | -3384 |
| PTPN22 | -1191 | 6886 | 8220 |
| TRAC | -11130 | -9675 | 7034 |
| TRAV19 | -9587 | -9220 | -3070 |
| TRAV29DV5 | -9353 | -9250 | -1621 |
| TRAV8-4 | -7010 | -4747 | 11211 |
| TRBC1 | -11646 | -9275 | 1902 |
| TRBV12-3 | -10099 | -9942 | -8483 |
| TRBV7-9 | -9220 | -8276 | -4880 |
| ZAP70 | -11590 | -8727 | -6587 |
Uptake and function of anthrax toxins
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.000314 |
| p.adjustMANOVA | 0.0011 |
| s.dist | 1.02 |
| s.t0_v_pod | 0.704 |
| s.pod_crp | 0.617 |
| s.t0_crp | -0.403 |
| p.t0_v_pod | 0.000117 |
| p.pod_crp | 0.000733 |
| p.t0_crp | 0.0274 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| FURIN | 8922 | 10706 |
| MAP2K6 | 8739 | 10757 |
| MAP2K1 | 8910 | 9974 |
| MAP2K3 | 8604 | 10197 |
| PDCD6IP | 6440 | 9153 |
| MAP2K4 | 6770 | 7655 |
| MAP2K2 | 6699 | 7135 |
| ANTXR2 | 7221 | 5582 |
| MAP2K7 | 1641 | 1537 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ANTXR2 | 7221 | 5582 | -7472 |
| CALM1 | -2039 | -1234 | 3538 |
| FURIN | 8922 | 10706 | -8995 |
| MAP2K1 | 8910 | 9974 | -7128 |
| MAP2K2 | 6699 | 7135 | -8945 |
| MAP2K3 | 8604 | 10197 | -6582 |
| MAP2K4 | 6770 | 7655 | 1313 |
| MAP2K6 | 8739 | 10757 | 6512 |
| MAP2K7 | 1641 | 1537 | -7635 |
| PDCD6IP | 6440 | 9153 | 8901 |
Regulation of TLR by endogenous ligand
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000254 |
| p.adjustMANOVA | 0.000911 |
| s.dist | 1 |
| s.t0_v_pod | 0.743 |
| s.pod_crp | 0.645 |
| s.t0_crp | -0.202 |
| p.t0_v_pod | 1.95e-05 |
| p.pod_crp | 0.000214 |
| p.t0_crp | 0.246 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| S100A8 | 9341 | 10975 |
| CD36 | 9283 | 10747 |
| S100A9 | 9353 | 10428 |
| TLR2 | 8950 | 10352 |
| TLR1 | 8782 | 9888 |
| CD14 | 8944 | 9321 |
| TLR4 | 8864 | 9402 |
| LY96 | 8649 | 9181 |
| TLR6 | 8694 | 8940 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CD14 | 8944 | 9321 | -7666 |
| CD36 | 9283 | 10747 | -147 |
| HMGB1 | -251 | -6674 | 2350 |
| LY96 | 8649 | 9181 | 4818 |
| S100A1 | -7825 | -680 | 3274 |
| S100A8 | 9341 | 10975 | -5317 |
| S100A9 | 9353 | 10428 | -7018 |
| TLR1 | 8782 | 9888 | 5302 |
| TLR2 | 8950 | 10352 | 3541 |
| TLR4 | 8864 | 9402 | -2478 |
| TLR6 | 8694 | 8940 | -2193 |
VLDLR internalisation and degradation
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 9.65e-06 |
| p.adjustMANOVA | 5.4e-05 |
| s.dist | 0.987 |
| s.t0_v_pod | 0.468 |
| s.pod_crp | 0.539 |
| s.t0_crp | -0.682 |
| p.t0_v_pod | 0.00718 |
| p.pod_crp | 0.00196 |
| p.t0_crp | 8.98e-05 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| AP2M1 | -8821 | 8674 |
| AP2A1 | -6175 | 11125 |
| AP2A2 | -6585 | 10047 |
| NR1H2 | -6941 | 9374 |
| AP2S1 | -7630 | 7940 |
| CLTA | -5807 | 7078 |
| CLTC | -1573 | 10126 |
| VLDLR | -2403 | 6177 |
| NR1H3 | -7769 | 944 |
| AP2B1 | -1439 | 2884 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AP2A1 | 6737 | 11125 | -6175 |
| AP2A2 | 7150 | 10047 | -6585 |
| AP2B1 | -2641 | 2884 | -1439 |
| AP2M1 | 8486 | 8674 | -8821 |
| AP2S1 | 7903 | 7940 | -7630 |
| CLTA | 8244 | 7078 | -5807 |
| CLTC | 8849 | 10126 | -1573 |
| MYLIP | -3870 | -4866 | -6799 |
| NR1H2 | 7304 | 9374 | -6941 |
| NR1H3 | -3491 | 944 | -7769 |
| VLDLR | -4246 | 6177 | -2403 |
L13a-mediated translational silencing of Ceruloplasmin expression
| metric | value |
|---|---|
| setSize | 110 |
| pMANOVA | 6.8e-80 |
| p.adjustMANOVA | 1.85e-77 |
| s.dist | 0.987 |
| s.t0_v_pod | -0.143 |
| s.pod_crp | -0.676 |
| s.t0_crp | -0.704 |
| p.t0_v_pod | 0.00949 |
| p.pod_crp | 1.43e-34 |
| p.t0_crp | 1.92e-37 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| FAU | -359 | -3599 | -8841 |
| PABPC1 | 5290 | -2972 | 2666 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
GTP hydrolysis and joining of the 60S ribosomal subunit
| metric | value |
|---|---|
| setSize | 111 |
| pMANOVA | 4.93e-78 |
| p.adjustMANOVA | 9.59e-76 |
| s.dist | 0.972 |
| s.t0_v_pod | -0.147 |
| s.pod_crp | -0.671 |
| s.t0_crp | -0.688 |
| p.t0_v_pod | 0.00738 |
| p.pod_crp | 2.12e-34 |
| p.t0_crp | 4.08e-36 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| EIF5 | 2162 | 2911 | 7027 |
| EIF5B | -4487 | -6842 | 9045 |
| FAU | -359 | -3599 | -8841 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Response of EIF2AK4 (GCN2) to amino acid deficiency
| metric | value |
|---|---|
| setSize | 100 |
| pMANOVA | 2.15e-62 |
| p.adjustMANOVA | 1.63e-60 |
| s.dist | 0.969 |
| s.t0_v_pod | -0.222 |
| s.pod_crp | -0.669 |
| s.t0_crp | -0.666 |
| p.t0_v_pod | 0.000128 |
| p.pod_crp | 5.65e-31 |
| p.t0_crp | 1.06e-30 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
| RPS5 | -9014 | -8342 |
| RPL18A | -8868 | -8439 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ASNS | -8030 | -7745 | 6843 |
| ATF2 | 2072 | -649 | 9372 |
| ATF3 | -9357 | -4266 | 10016 |
| ATF4 | 6151 | -53 | -5554 |
| CEBPB | 7875 | 10929 | -2749 |
| CEBPG | 5401 | 4172 | 6082 |
| DDIT3 | 4850 | 6412 | 5869 |
| EIF2AK4 | 41 | -1643 | -6653 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| FAU | -359 | -3599 | -8841 |
| GCN1 | -10036 | -5601 | -359 |
| IMPACT | -3125 | -5573 | 8929 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| TRIB3 | -5649 | 2473 | 4697 |
| UBA52 | 1112 | -3471 | -8207 |
Advanced glycosylation endproduct receptor signaling
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 9.21e-05 |
| p.adjustMANOVA | 0.000381 |
| s.dist | 0.968 |
| s.t0_v_pod | 0.65 |
| s.pod_crp | 0.542 |
| s.t0_crp | -0.47 |
| p.t0_v_pod | 9.71e-05 |
| p.pod_crp | 0.00114 |
| p.t0_crp | 0.00478 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| S100A12 | 9352 | 10996 |
| MAPK3 | 8803 | 9593 |
| MAPK1 | 7381 | 10983 |
| LGALS3 | 8608 | 9045 |
| CAPZA1 | 8008 | 9383 |
| CAPZA2 | 8457 | 8110 |
| DDOST | 6831 | 8345 |
| APP | 9022 | 6180 |
| PRKCSH | 5159 | 6756 |
| AGER | 1284 | 4851 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AGER | 1284 | 4851 | -781 |
| APP | 9022 | 6180 | -6109 |
| CAPZA1 | 8008 | 9383 | 6293 |
| CAPZA2 | 8457 | 8110 | 4868 |
| DDOST | 6831 | 8345 | -8761 |
| HMGB1 | -251 | -6674 | 2350 |
| LGALS3 | 8608 | 9045 | -4982 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| PRKCSH | 5159 | 6756 | -8725 |
| S100A12 | 9352 | 10996 | -7985 |
| S100B | -5273 | -1338 | -6095 |
Cap-dependent Translation Initiation
| metric | value |
|---|---|
| setSize | 118 |
| pMANOVA | 3.48e-76 |
| p.adjustMANOVA | 5.26e-74 |
| s.dist | 0.927 |
| s.t0_v_pod | -0.132 |
| s.pod_crp | -0.637 |
| s.t0_crp | -0.661 |
| p.t0_v_pod | 0.0135 |
| p.pod_crp | 5.36e-33 |
| p.t0_crp | 1.74e-35 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2B1 | -411 | -2213 | 5744 |
| EIF2B2 | 3233 | 7405 | -4631 |
| EIF2B3 | -7934 | -6624 | 3358 |
| EIF2B4 | 2685 | 4256 | -5692 |
| EIF2B5 | -9484 | -5556 | -804 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4EBP1 | 5990 | 2800 | -6475 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| EIF5 | 2162 | 2911 | 7027 |
| EIF5B | -4487 | -6842 | 9045 |
| FAU | -359 | -3599 | -8841 |
| PABPC1 | 5290 | -2972 | 2666 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Eukaryotic Translation Initiation
| metric | value |
|---|---|
| setSize | 118 |
| pMANOVA | 3.48e-76 |
| p.adjustMANOVA | 5.26e-74 |
| s.dist | 0.927 |
| s.t0_v_pod | -0.132 |
| s.pod_crp | -0.637 |
| s.t0_crp | -0.661 |
| p.t0_v_pod | 0.0135 |
| p.pod_crp | 5.36e-33 |
| p.t0_crp | 1.74e-35 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2B1 | -411 | -2213 | 5744 |
| EIF2B2 | 3233 | 7405 | -4631 |
| EIF2B3 | -7934 | -6624 | 3358 |
| EIF2B4 | 2685 | 4256 | -5692 |
| EIF2B5 | -9484 | -5556 | -804 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4EBP1 | 5990 | 2800 | -6475 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| EIF5 | 2162 | 2911 | 7027 |
| EIF5B | -4487 | -6842 | 9045 |
| FAU | -359 | -3599 | -8841 |
| PABPC1 | 5290 | -2972 | 2666 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| UBA52 | 1112 | -3471 | -8207 |
Formation of the ternary complex, and subsequently, the 43S complex
| metric | value |
|---|---|
| setSize | 51 |
| pMANOVA | 1.55e-36 |
| p.adjustMANOVA | 6.18e-35 |
| s.dist | 0.922 |
| s.t0_v_pod | -0.0831 |
| s.pod_crp | -0.662 |
| s.t0_crp | -0.636 |
| p.t0_v_pod | 0.305 |
| p.pod_crp | 2.68e-16 |
| p.t0_crp | 3.83e-15 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPS27 | -9147 | -8693 |
| RPS23 | -9359 | -8319 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPS5 | -9014 | -8342 |
| RPS25 | -9636 | -7764 |
| RPS10 | -8466 | -8823 |
| RPS15A | -8855 | -8431 |
| RPS16 | -8551 | -8704 |
| RPS17 | -8254 | -8928 |
| RPS14 | -8513 | -8637 |
| RPS21 | -8303 | -8855 |
| EIF3L | -8228 | -8813 |
| EIF3B | -9498 | -7620 |
| RPS7 | -9137 | -7874 |
| RPS11 | -7948 | -8743 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| FAU | -359 | -3599 | -8841 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
WNT5A-dependent internalization of FZD4
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 9.7e-06 |
| p.adjustMANOVA | 5.41e-05 |
| s.dist | 0.917 |
| s.t0_v_pod | 0.449 |
| s.pod_crp | 0.525 |
| s.t0_crp | -0.603 |
| p.t0_v_pod | 0.00507 |
| p.pod_crp | 0.00105 |
| p.t0_crp | 0.000168 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| ARRB2 | -7583 | 10498 |
| AP2M1 | -8821 | 8674 |
| AP2A1 | -6175 | 11125 |
| CLTB | -8646 | 7866 |
| AP2A2 | -6585 | 10047 |
| AP2S1 | -7630 | 7940 |
| CLTA | -5807 | 7078 |
| PRKCB | -4547 | 8456 |
| CLTC | -1573 | 10126 |
| AP2B1 | -1439 | 2884 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AP2A1 | 6737 | 11125 | -6175 |
| AP2A2 | 7150 | 10047 | -6585 |
| AP2B1 | -2641 | 2884 | -1439 |
| AP2M1 | 8486 | 8674 | -8821 |
| AP2S1 | 7903 | 7940 | -7630 |
| ARRB2 | 8355 | 10498 | -7583 |
| CLTA | 8244 | 7078 | -5807 |
| CLTB | 6002 | 7866 | -8646 |
| CLTC | 8849 | 10126 | -1573 |
| DVL2 | -10804 | -5613 | -6082 |
| FZD4 | -11295 | 3467 | 6990 |
| PRKCA | 1123 | -2393 | -4303 |
| PRKCB | 6993 | 8456 | -4547 |
Erythrocytes take up carbon dioxide and release oxygen
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00111 |
| p.adjustMANOVA | 0.00322 |
| s.dist | 0.895 |
| s.t0_v_pod | 0.68 |
| s.pod_crp | 0.527 |
| s.t0_crp | -0.247 |
| p.t0_v_pod | 9.48e-05 |
| p.pod_crp | 0.00248 |
| p.t0_crp | 0.157 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CYB5R1 | 9299 | 10846 |
| CA1 | 9220 | 8103 |
| CYB5R4 | 8289 | 8868 |
| CYB5R2 | 8460 | 8619 |
| SLC4A1 | 8987 | 7437 |
| HBB | 8901 | 6625 |
| AQP1 | 7364 | 7882 |
| HBA1 | 8840 | 6172 |
| CA4 | 2804 | 10795 |
| CA2 | 3538 | 41 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AQP1 | 7364 | 7882 | -3543 |
| CA1 | 9220 | 8103 | 1441 |
| CA2 | 3538 | 41 | -772 |
| CA4 | 2804 | 10795 | -633 |
| CYB5R1 | 9299 | 10846 | -8590 |
| CYB5R2 | 8460 | 8619 | -2064 |
| CYB5R4 | 8289 | 8868 | 2856 |
| CYB5RL | -10419 | -7341 | 1351 |
| HBA1 | 8840 | 6172 | -11 |
| HBB | 8901 | 6625 | 214 |
| SLC4A1 | 8987 | 7437 | -1041 |
O2/CO2 exchange in erythrocytes
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00111 |
| p.adjustMANOVA | 0.00322 |
| s.dist | 0.895 |
| s.t0_v_pod | 0.68 |
| s.pod_crp | 0.527 |
| s.t0_crp | -0.247 |
| p.t0_v_pod | 9.48e-05 |
| p.pod_crp | 0.00248 |
| p.t0_crp | 0.157 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CYB5R1 | 9299 | 10846 |
| CA1 | 9220 | 8103 |
| CYB5R4 | 8289 | 8868 |
| CYB5R2 | 8460 | 8619 |
| SLC4A1 | 8987 | 7437 |
| HBB | 8901 | 6625 |
| AQP1 | 7364 | 7882 |
| HBA1 | 8840 | 6172 |
| CA4 | 2804 | 10795 |
| CA2 | 3538 | 41 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AQP1 | 7364 | 7882 | -3543 |
| CA1 | 9220 | 8103 | 1441 |
| CA2 | 3538 | 41 | -772 |
| CA4 | 2804 | 10795 | -633 |
| CYB5R1 | 9299 | 10846 | -8590 |
| CYB5R2 | 8460 | 8619 | -2064 |
| CYB5R4 | 8289 | 8868 | 2856 |
| CYB5RL | -10419 | -7341 | 1351 |
| HBA1 | 8840 | 6172 | -11 |
| HBB | 8901 | 6625 | 214 |
| SLC4A1 | 8987 | 7437 | -1041 |
Retrograde neurotrophin signalling
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000363 |
| p.adjustMANOVA | 0.00125 |
| s.dist | 0.893 |
| s.t0_v_pod | 0.566 |
| s.pod_crp | 0.517 |
| s.t0_crp | -0.457 |
| p.t0_v_pod | 0.00068 |
| p.pod_crp | 0.00193 |
| p.t0_crp | 0.00611 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CLTC | 8849 | 10126 |
| AP2A1 | 6737 | 11125 |
| AP2M1 | 8486 | 8674 |
| AP2A2 | 7150 | 10047 |
| AP2S1 | 7903 | 7940 |
| DNM2 | 6007 | 10193 |
| CLTA | 8244 | 7078 |
| DNM3 | 6942 | 3491 |
| DNM1 | 3555 | 5937 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AP2A1 | 6737 | 11125 | -6175 |
| AP2A2 | 7150 | 10047 | -6585 |
| AP2B1 | -2641 | 2884 | -1439 |
| AP2M1 | 8486 | 8674 | -8821 |
| AP2S1 | 7903 | 7940 | -7630 |
| CLTA | 8244 | 7078 | -5807 |
| CLTC | 8849 | 10126 | -1573 |
| DNAL4 | 3369 | -755 | -8239 |
| DNM1 | 3555 | 5937 | 9244 |
| DNM2 | 6007 | 10193 | -7994 |
| DNM3 | 6942 | 3491 | -1083 |
| NTRK1 | -7910 | -3772 | 7353 |
RNA Polymerase I Promoter Opening
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 8.92e-07 |
| p.adjustMANOVA | 6.77e-06 |
| s.dist | 0.886 |
| s.t0_v_pod | 0.616 |
| s.pod_crp | 0.412 |
| s.t0_crp | -0.486 |
| p.t0_v_pod | 3.31e-06 |
| p.pod_crp | 0.00189 |
| p.t0_crp | 0.000246 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| MAPK3 | 8803.0 | -9014.0 |
| H2AJ | 9214.0 | -8302.0 |
| H2BC12 | 8898.0 | -7833.0 |
| H2AZ1 | 5955.0 | -8609.0 |
| H2BC5 | 7881.0 | -5603.0 |
| H2BC11 | 7791.0 | -5097.0 |
| H2BC21 | 9125.0 | -3628.0 |
| H3C15 | 6608.5 | -4548.5 |
| H2BC9 | 5332.0 | -5547.0 |
| H2AC6 | 7813.0 | -3405.0 |
| H2BC15 | 5251.0 | -2358.0 |
| H2BC17 | 7178.0 | -839.0 |
| H2BC4 | 7279.0 | -558.0 |
| H3-3A | 8519.0 | -45.0 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| H2AC20 | 4913.0 | 8767.0 | 5501.0 |
| H2AC6 | 7813.0 | 5389.0 | -3405.0 |
| H2AJ | 9214.0 | 11227.0 | -8302.0 |
| H2AZ1 | 5955.0 | 4339.0 | -8609.0 |
| H2AZ2 | -1192.0 | -5552.0 | -5889.0 |
| H2BC11 | 7791.0 | 6057.0 | -5097.0 |
| H2BC12 | 8898.0 | 9140.0 | -7833.0 |
| H2BC15 | 5251.0 | 2455.0 | -2358.0 |
| H2BC17 | 7178.0 | 6124.0 | -839.0 |
| H2BC21 | 9125.0 | 9536.0 | -3628.0 |
| H2BC4 | 7279.0 | 8798.0 | -558.0 |
| H2BC5 | 7881.0 | 6685.0 | -5603.0 |
| H2BC9 | 5332.0 | -5704.0 | -5547.0 |
| H2BU1 | -6332.0 | 296.0 | 1215.0 |
| H3-3A | 8519.0 | 8858.0 | -45.0 |
| H3C15 | 6608.5 | 8802.5 | -4548.5 |
| MAPK3 | 8803.0 | 9593.0 | -9014.0 |
| MBD2 | 6491.0 | 7521.0 | 3253.0 |
| UBTF | -9703.0 | -8220.0 | -5824.0 |
Selenoamino acid metabolism
| metric | value |
|---|---|
| setSize | 114 |
| pMANOVA | 2.96e-56 |
| p.adjustMANOVA | 1.92e-54 |
| s.dist | 0.876 |
| s.t0_v_pod | -0.228 |
| s.pod_crp | -0.617 |
| s.t0_crp | -0.579 |
| p.t0_v_pod | 2.52e-05 |
| p.pod_crp | 4.37e-30 |
| p.t0_crp | 1.11e-26 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
| RPS5 | -9014 | -8342 |
| RPL18A | -8868 | -8439 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AHCY | 460 | -2495 | -8323 |
| AIMP1 | -5707 | -7963 | 10294 |
| AIMP2 | -976 | -3324 | -1112 |
| CBS | 6846 | 11022 | 11440 |
| CTH | -7898 | -629 | 9466 |
| DARS1 | 1060 | -6914 | 8724 |
| EEF1E1 | -2031 | -2699 | 4504 |
| EEFSEC | -9700 | -6468 | -2666 |
| EPRS1 | -3100 | -6325 | 5993 |
| FAU | -359 | -3599 | -8841 |
| GNMT | 2014 | 2894 | -2674 |
| GSR | 9078 | 10845 | -6395 |
| HNMT | 8186 | 6356 | -2637 |
| IARS1 | -11539 | -8971 | 6521 |
| INMT | 2159 | -379 | 7393 |
| KARS1 | -5204 | -8353 | 5267 |
| LARS1 | -6211 | -9609 | 10684 |
| MARS1 | -2525 | 7268 | 5522 |
| PAPSS1 | 8852 | 10157 | 1039 |
| PAPSS2 | -2738 | 11055 | 11302 |
| PSTK | -9857 | -5686 | 3544 |
| QARS1 | 85 | -3737 | -8534 |
| RARS1 | -4641 | -3923 | 9769 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SARS1 | -5712 | -6019 | -7676 |
| SCLY | -7964 | -7618 | -1202 |
| SECISBP2 | -9999 | -6967 | 10570 |
| SEPHS2 | 7535 | 7977 | -4587 |
| SEPSECS | -10939 | -7931 | 10064 |
| TXNRD1 | 8062 | 9724 | -2030 |
| UBA52 | 1112 | -3471 | -8207 |
Gap junction trafficking
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.000388 |
| p.adjustMANOVA | 0.00132 |
| s.dist | 0.872 |
| s.t0_v_pod | 0.564 |
| s.pod_crp | 0.553 |
| s.t0_crp | -0.37 |
| p.t0_v_pod | 0.000432 |
| p.pod_crp | 0.000556 |
| p.t0_crp | 0.0211 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CLTC | 8849 | 10126 |
| DAB2 | 7985 | 10458 |
| GJD3 | 7874 | 10400 |
| CLTCL1 | 8815 | 9065 |
| AP2M1 | 8486 | 8674 |
| DNM2 | 6007 | 10193 |
| CLTA | 8244 | 7078 |
| CLTB | 6002 | 7866 |
| DNM1 | 3555 | 5937 |
| GJB6 | 4708 | 3501 |
| GJC1 | 512 | 4925 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AP2M1 | 8486 | 8674 | -8821 |
| CLTA | 8244 | 7078 | -5807 |
| CLTB | 6002 | 7866 | -8646 |
| CLTC | 8849 | 10126 | -1573 |
| CLTCL1 | 8815 | 9065 | -5876 |
| DAB2 | 7985 | 10458 | -7333 |
| DNM1 | 3555 | 5937 | 9244 |
| DNM2 | 6007 | 10193 | -7994 |
| GJB6 | 4708 | 3501 | -8822 |
| GJC1 | 512 | 4925 | 4580 |
| GJC2 | 1074 | -686 | -452 |
| GJD3 | 7874 | 10400 | 4052 |
| MYO6 | -11058 | -3503 | 7640 |
SRP-dependent cotranslational protein targeting to membrane
| metric | value |
|---|---|
| setSize | 111 |
| pMANOVA | 8.28e-60 |
| p.adjustMANOVA | 5.63e-58 |
| s.dist | 0.861 |
| s.t0_v_pod | -0.134 |
| s.pod_crp | -0.583 |
| s.t0_crp | -0.62 |
| p.t0_v_pod | 0.0148 |
| p.pod_crp | 2.36e-26 |
| p.t0_crp | 1.27e-29 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DDOST | 6831 | 8345 | -8761 |
| FAU | -359 | -3599 | -8841 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPN1 | 7902 | 7066 | -6768 |
| RPN2 | 7035 | 8748 | -1401 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SEC11A | 7799 | 6562 | -2808 |
| SEC11C | -8699 | -6021 | 10562 |
| SEC61A1 | 6361 | 7393 | -2601 |
| SEC61A2 | -10455 | -5309 | 7759 |
| SEC61B | 6910 | 4284 | -7952 |
| SEC61G | 4656 | -3133 | 8410 |
| SPCS1 | 2996 | -1687 | -2226 |
| SPCS2 | 3184 | -967 | 7256 |
| SPCS3 | 4326 | 1951 | 9517 |
| SRP14 | 6234 | 4977 | 998 |
| SRP19 | 4236 | -617 | 11340 |
| SRP54 | 6501 | 7811 | 11918 |
| SRP68 | 2001 | 779 | -302 |
| SRP72 | -1470 | -3543 | 5095 |
| SRP9 | 4400 | -3395 | 5210 |
| SRPRA | 4999 | 8185 | -3928 |
| SRPRB | -9099 | -7494 | 4311 |
| SSR1 | 6498 | 1133 | 1939 |
| SSR2 | 2796 | -2899 | -5127 |
| SSR3 | 5856 | 2491 | 5639 |
| SSR4 | 3109 | 1282 | -6690 |
| TRAM1 | -4486 | -6455 | 7719 |
| UBA52 | 1112 | -3471 | -8207 |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
| metric | value |
|---|---|
| setSize | 114 |
| pMANOVA | 2.07e-55 |
| p.adjustMANOVA | 1.17e-53 |
| s.dist | 0.859 |
| s.t0_v_pod | -0.195 |
| s.pod_crp | -0.585 |
| s.t0_crp | -0.597 |
| p.t0_v_pod | 0.000316 |
| p.pod_crp | 3.11e-27 |
| p.t0_crp | 2.66e-28 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CASC3 | 5181 | 9457 | -2175 |
| DCP1A | -5260 | -4817 | 9790 |
| EIF4A3 | 7166 | 1494 | -7095 |
| EIF4G1 | 7908 | 10325 | -6629 |
| ETF1 | 7308 | 6760 | 4048 |
| FAU | -359 | -3599 | -8841 |
| GSPT1 | 6387 | -2011 | 8737 |
| GSPT2 | -10067 | -7968 | 1941 |
| MAGOH | 1045 | -4656 | -8927 |
| MAGOHB | -9011 | -6701 | 7191 |
| NCBP1 | -5659 | -933 | 11205 |
| NCBP2 | -9239 | -9603 | 10774 |
| PABPC1 | 5290 | -2972 | 2666 |
| PNRC2 | -4406 | -3709 | 11240 |
| PPP2CA | 8104 | 6731 | -306 |
| PPP2R1A | 4542 | 5140 | -7934 |
| PPP2R2A | 4102 | 1773 | 12144 |
| RBM8A | -7139 | -1486 | -4793 |
| RNPS1 | -11075 | -8003 | -3497 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SMG1 | -4341 | -483 | 7115 |
| SMG5 | 5264 | 4820 | -7444 |
| SMG6 | -6032 | -474 | -2511 |
| SMG7 | 6519 | 10196 | 7365 |
| SMG8 | 2894 | 4950 | 6371 |
| SMG9 | 204 | 6197 | 490 |
| UBA52 | 1112 | -3471 | -8207 |
| UPF1 | 4629 | 8973 | -3684 |
| UPF2 | 957 | 1269 | 10321 |
| UPF3A | -9509 | -8767 | -1235 |
| UPF3B | -8003 | -5819 | 6796 |
Nonsense-Mediated Decay (NMD)
| metric | value |
|---|---|
| setSize | 114 |
| pMANOVA | 2.07e-55 |
| p.adjustMANOVA | 1.17e-53 |
| s.dist | 0.859 |
| s.t0_v_pod | -0.195 |
| s.pod_crp | -0.585 |
| s.t0_crp | -0.597 |
| p.t0_v_pod | 0.000316 |
| p.pod_crp | 3.11e-27 |
| p.t0_crp | 2.66e-28 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPL3 | -8773 | -9928 |
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPL14 | -8650 | -9670 |
| RPLP2 | -9001 | -9135 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPLP0 | -8702 | -9199 |
| RPS27 | -8693 | -9147 |
| RPL10 | -8829 | -9003 |
| RPL7 | -8087 | -9737 |
| RPS23 | -8319 | -9359 |
| RPL27A | -8573 | -9020 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPL31 | -8685 | -8741 |
| RPL30 | -8504 | -8902 |
| RPL29 | -8787 | -8593 |
| RPS5 | -8342 | -9014 |
| RPL18A | -8439 | -8868 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CASC3 | 5181 | 9457 | -2175 |
| DCP1A | -5260 | -4817 | 9790 |
| EIF4A3 | 7166 | 1494 | -7095 |
| EIF4G1 | 7908 | 10325 | -6629 |
| ETF1 | 7308 | 6760 | 4048 |
| FAU | -359 | -3599 | -8841 |
| GSPT1 | 6387 | -2011 | 8737 |
| GSPT2 | -10067 | -7968 | 1941 |
| MAGOH | 1045 | -4656 | -8927 |
| MAGOHB | -9011 | -6701 | 7191 |
| NCBP1 | -5659 | -933 | 11205 |
| NCBP2 | -9239 | -9603 | 10774 |
| PABPC1 | 5290 | -2972 | 2666 |
| PNRC2 | -4406 | -3709 | 11240 |
| PPP2CA | 8104 | 6731 | -306 |
| PPP2R1A | 4542 | 5140 | -7934 |
| PPP2R2A | 4102 | 1773 | 12144 |
| RBM8A | -7139 | -1486 | -4793 |
| RNPS1 | -11075 | -8003 | -3497 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SMG1 | -4341 | -483 | 7115 |
| SMG5 | 5264 | 4820 | -7444 |
| SMG6 | -6032 | -474 | -2511 |
| SMG7 | 6519 | 10196 | 7365 |
| SMG8 | 2894 | 4950 | 6371 |
| SMG9 | 204 | 6197 | 490 |
| UBA52 | 1112 | -3471 | -8207 |
| UPF1 | 4629 | 8973 | -3684 |
| UPF2 | 957 | 1269 | 10321 |
| UPF3A | -9509 | -8767 | -1235 |
| UPF3B | -8003 | -5819 | 6796 |
Unwinding of DNA
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00163 |
| p.adjustMANOVA | 0.00455 |
| s.dist | 0.854 |
| s.t0_v_pod | -0.637 |
| s.pod_crp | -0.568 |
| s.t0_crp | 0.0087 |
| p.t0_v_pod | 0.000133 |
| p.pod_crp | 0.000652 |
| p.t0_crp | 0.958 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| MCM3 | -11839 | -9914 |
| MCM7 | -11768 | -9297 |
| GINS4 | -9903 | -8248 |
| MCM6 | -9393 | -8603 |
| MCM8 | -10599 | -5689 |
| MCM4 | -8404 | -7061 |
| MCM2 | -6973 | -6855 |
| GINS3 | -10170 | -3854 |
| MCM5 | -7039 | -2312 |
| GINS2 | -4661 | -3457 |
| CDC45 | -2594 | -5110 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CDC45 | -2594 | -5110 | 1889 |
| GINS1 | -4261 | 4225 | 7950 |
| GINS2 | -4661 | -3457 | 4094 |
| GINS3 | -10170 | -3854 | 5122 |
| GINS4 | -9903 | -8248 | 3992 |
| MCM2 | -6973 | -6855 | -3428 |
| MCM3 | -11839 | -9914 | -2392 |
| MCM4 | -8404 | -7061 | 3202 |
| MCM5 | -7039 | -2312 | -5776 |
| MCM6 | -9393 | -8603 | 109 |
| MCM7 | -11768 | -9297 | -1374 |
| MCM8 | -10599 | -5689 | 7587 |
RHO GTPases Activate WASPs and WAVEs
| metric | value |
|---|---|
| setSize | 35 |
| pMANOVA | 2.05e-09 |
| p.adjustMANOVA | 2.58e-08 |
| s.dist | 0.847 |
| s.t0_v_pod | 0.608 |
| s.pod_crp | 0.542 |
| s.t0_crp | -0.232 |
| p.t0_v_pod | 4.76e-10 |
| p.pod_crp | 2.9e-08 |
| p.t0_crp | 0.0178 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| WASF1 | 9357 | 11114 |
| GRB2 | 9146 | 10542 |
| ARPC1B | 9102 | 10587 |
| ARPC1A | 8745 | 10779 |
| CYFIP1 | 9108 | 10239 |
| ACTB | 8859 | 10421 |
| RAC1 | 8647 | 10438 |
| WAS | 8421 | 10583 |
| WASF2 | 8237 | 10611 |
| ARPC5 | 8544 | 9930 |
| MAPK3 | 8803 | 9593 |
| NCKAP1L | 7557 | 11091 |
| MAPK1 | 7381 | 10983 |
| ACTG1 | 8423 | 9524 |
| BTK | 7100 | 10653 |
| ARPC3 | 8147 | 8602 |
| ARPC4 | 7404 | 9441 |
| ACTR2 | 7750 | 8769 |
| ACTR3 | 7699 | 8747 |
| ARPC2 | 7280 | 8886 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ABI1 | 6978 | 9231 | 9895 |
| ABI2 | -10571 | -8147 | 5541 |
| ABL1 | 224 | 6063 | -4841 |
| ACTB | 8859 | 10421 | -4561 |
| ACTG1 | 8423 | 9524 | -7556 |
| ACTR2 | 7750 | 8769 | 5308 |
| ACTR3 | 7699 | 8747 | 3145 |
| ARPC1A | 8745 | 10779 | 2238 |
| ARPC1B | 9102 | 10587 | -8003 |
| ARPC2 | 7280 | 8886 | -214 |
| ARPC3 | 8147 | 8602 | 3314 |
| ARPC4 | 7404 | 9441 | -4920 |
| ARPC5 | 8544 | 9930 | 1879 |
| BAIAP2 | -215 | -1864 | -5732 |
| BRK1 | 6929 | -2546 | -8964 |
| BTK | 7100 | 10653 | 7751 |
| CDC42 | 7425 | 8226 | 5599 |
| CYFIP1 | 9108 | 10239 | -6102 |
| CYFIP2 | -10031 | -766 | 1789 |
| GRB2 | 9146 | 10542 | -5185 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| NCK1 | -11102 | -8947 | 3344 |
| NCKAP1 | 7350 | 8736 | 3265 |
| NCKAP1L | 7557 | 11091 | 1697 |
| NCKIPSD | 326 | -3672 | -7752 |
| PTK2 | 4418 | 385 | -619 |
| RAC1 | 8647 | 10438 | 3441 |
| WAS | 8421 | 10583 | -4535 |
| WASF1 | 9357 | 11114 | -4960 |
| WASF2 | 8237 | 10611 | -3673 |
| WASF3 | 6713 | -1351 | -7526 |
| WASL | 297 | 3268 | 7557 |
| WIPF1 | 563 | 3110 | -2585 |
| WIPF2 | 5640 | 8576 | 3912 |
RHO GTPases Activate NADPH Oxidases
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 2.87e-06 |
| p.adjustMANOVA | 1.87e-05 |
| s.dist | 0.844 |
| s.t0_v_pod | 0.559 |
| s.pod_crp | 0.472 |
| s.t0_crp | -0.422 |
| p.t0_v_pod | 9.31e-06 |
| p.pod_crp | 0.000179 |
| p.t0_crp | 0.000825 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| S100A8 | 9341 | 10975 |
| MAPK14 | 8951 | 10908 |
| S100A9 | 9353 | 10428 |
| PRKCD | 8856 | 10959 |
| NCF4 | 9111 | 10617 |
| NCF2 | 9034 | 10598 |
| RAC1 | 8647 | 10438 |
| MAPK3 | 8803 | 9593 |
| CYBB | 8879 | 9506 |
| MAPK1 | 7381 | 10983 |
| CYBA | 6822 | 9999 |
| PRKCB | 6993 | 8456 |
| NCF1 | 7224 | 7158 |
| RAC2 | 5104 | 8122 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CYBA | 6822 | 9999 | -7207 |
| CYBB | 8879 | 9506 | 1575 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK11 | 3788 | -4619 | 1873 |
| MAPK14 | 8951 | 10908 | -1066 |
| MAPK3 | 8803 | 9593 | -9014 |
| NCF1 | 7224 | 7158 | -2796 |
| NCF2 | 9034 | 10598 | -2149 |
| NCF4 | 9111 | 10617 | -6708 |
| NOXA1 | -5279 | -4892 | -3091 |
| PIK3C3 | 1606 | -1705 | 8122 |
| PIK3R4 | -3937 | -2083 | 5203 |
| PIN1 | -3103 | 571 | -8554 |
| PRKCA | 1123 | -2393 | -4303 |
| PRKCB | 6993 | 8456 | -4547 |
| PRKCD | 8856 | 10959 | -3359 |
| PRKCZ | -11275 | -5992 | -6068 |
| RAC1 | 8647 | 10438 | 3441 |
| RAC2 | 5104 | 8122 | -7294 |
| S100A8 | 9341 | 10975 | -5317 |
| S100A9 | 9353 | 10428 | -7018 |
Translation initiation complex formation
| metric | value |
|---|---|
| setSize | 58 |
| pMANOVA | 2.43e-36 |
| p.adjustMANOVA | 9.45e-35 |
| s.dist | 0.829 |
| s.t0_v_pod | -0.0201 |
| s.pod_crp | -0.582 |
| s.t0_crp | -0.59 |
| p.t0_v_pod | 0.792 |
| p.pod_crp | 1.77e-14 |
| p.t0_crp | 7.54e-15 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPS27 | -8693 | -9147 |
| RPS23 | -8319 | -9359 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPS5 | -8342 | -9014 |
| RPS25 | -7764 | -9636 |
| RPS10 | -8823 | -8466 |
| RPS15A | -8431 | -8855 |
| RPS16 | -8704 | -8551 |
| RPS17 | -8928 | -8254 |
| RPS14 | -8637 | -8513 |
| RPS21 | -8855 | -8303 |
| EIF3L | -8813 | -8228 |
| EIF3B | -7620 | -9498 |
| RPS7 | -7874 | -9137 |
| RPS11 | -8743 | -7948 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| FAU | -359 | -3599 | -8841 |
| PABPC1 | 5290 | -2972 | 2666 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
RHO GTPases Activate ROCKs
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 8.92e-05 |
| p.adjustMANOVA | 0.000371 |
| s.dist | 0.824 |
| s.t0_v_pod | 0.541 |
| s.pod_crp | 0.621 |
| s.t0_crp | -0.0253 |
| p.t0_v_pod | 7.03e-05 |
| p.pod_crp | 5.02e-06 |
| p.t0_crp | 0.853 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| MYL6 | 10011 | 8436 |
| PAK1 | 9873 | 8100 |
| CFL1 | 9633 | 8057 |
| RHOA | 9259 | 8188 |
| LIMK2 | 9535 | 7949 |
| ROCK1 | 8572 | 7377 |
| MYH9 | 9088 | 6594 |
| PPP1CB | 6672 | 6960 |
| PPP1R12A | 7701 | 5969 |
| ROCK2 | 6540 | 6054 |
| LIMK1 | 7956 | 4628 |
| MYL12B | 5646 | 5029 |
| PPP1R12B | 8370 | 1762 |
| MYL9 | 1915 | 7587 |
| RHOB | 7820 | 1244 |
| MYH10 | 8510 | 647 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CFL1 | 8057 | 9633 | -8162 |
| LIMK1 | 4628 | 7956 | -5779 |
| LIMK2 | 7949 | 9535 | -1036 |
| MYH10 | 647 | 8510 | 7323 |
| MYH11 | -3419 | -2228 | 6330 |
| MYH9 | 6594 | 9088 | -6312 |
| MYL12B | 5029 | 5646 | -3168 |
| MYL6 | 8436 | 10011 | -8786 |
| MYL9 | 7587 | 1915 | -4389 |
| PAK1 | 8100 | 9873 | 7050 |
| PPP1CB | 6960 | 6672 | 7418 |
| PPP1R12A | 5969 | 7701 | 8978 |
| PPP1R12B | 1762 | 8370 | 5459 |
| RHOA | 8188 | 9259 | -372 |
| RHOB | 1244 | 7820 | 3590 |
| RHOC | -11009 | 4597 | 68 |
| ROCK1 | 7377 | 8572 | 9620 |
| ROCK2 | 6054 | 6540 | 7093 |
MET activates RAP1 and RAC1
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00615 |
| p.adjustMANOVA | 0.0139 |
| s.dist | 0.824 |
| s.t0_v_pod | 0.53 |
| s.pod_crp | 0.606 |
| s.t0_crp | 0.178 |
| p.t0_v_pod | 0.00371 |
| p.pod_crp | 0.00091 |
| p.t0_crp | 0.331 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| GRB2 | 10542 | 9146 |
| RAC1 | 10438 | 8647 |
| CRK | 10207 | 8756 |
| HGF | 10236 | 8715 |
| RAP1A | 7246 | 7198 |
| GAB1 | 8548 | 5607 |
| RAP1B | 6882 | 3179 |
| CRKL | 5201 | 3927 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CRK | 8756 | 10207 | 5223 |
| CRKL | 3927 | 5201 | -2305 |
| DOCK7 | -2317 | -4063 | 7144 |
| GAB1 | 5607 | 8548 | 9775 |
| GRB2 | 9146 | 10542 | -5185 |
| HGF | 8715 | 10236 | 7877 |
| RAC1 | 8647 | 10438 | 3441 |
| RAP1A | 7198 | 7246 | 9059 |
| RAP1B | 3179 | 6882 | 6183 |
| RAPGEF1 | -9501 | 5055 | -5674 |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
| metric | value |
|---|---|
| setSize | 59 |
| pMANOVA | 1.34e-36 |
| p.adjustMANOVA | 5.53e-35 |
| s.dist | 0.821 |
| s.t0_v_pod | -0.00808 |
| s.pod_crp | -0.568 |
| s.t0_crp | -0.593 |
| p.t0_v_pod | 0.915 |
| p.pod_crp | 4.24e-14 |
| p.t0_crp | 3.25e-15 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPS27 | -8693 | -9147 |
| RPS23 | -8319 | -9359 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPS5 | -8342 | -9014 |
| RPS25 | -7764 | -9636 |
| RPS10 | -8823 | -8466 |
| RPS15A | -8431 | -8855 |
| RPS16 | -8704 | -8551 |
| RPS17 | -8928 | -8254 |
| RPS14 | -8637 | -8513 |
| RPS21 | -8855 | -8303 |
| EIF3L | -8813 | -8228 |
| EIF3B | -7620 | -9498 |
| RPS7 | -7874 | -9137 |
| RPS11 | -8743 | -7948 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4EBP1 | 5990 | 2800 | -6475 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| FAU | -359 | -3599 | -8841 |
| PABPC1 | 5290 | -2972 | 2666 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
Ribosomal scanning and start codon recognition
| metric | value |
|---|---|
| setSize | 58 |
| pMANOVA | 6.98e-35 |
| p.adjustMANOVA | 2.5e-33 |
| s.dist | 0.817 |
| s.t0_v_pod | -0.0251 |
| s.pod_crp | -0.572 |
| s.t0_crp | -0.583 |
| p.t0_v_pod | 0.741 |
| p.pod_crp | 4.68e-14 |
| p.t0_crp | 1.57e-14 |
| Gene | t0_crp | pod_crp |
|---|---|---|
| RPS2 | -9021 | -9563 |
| RPS27A | -8668 | -9695 |
| RPS12 | -8852 | -9242 |
| RPS3 | -8726 | -9270 |
| RPS27 | -8693 | -9147 |
| RPS23 | -8319 | -9359 |
| RPS29 | -8958 | -8609 |
| RPS6 | -7892 | -9671 |
| RPS5 | -8342 | -9014 |
| RPS25 | -7764 | -9636 |
| RPS10 | -8823 | -8466 |
| RPS15A | -8431 | -8855 |
| RPS16 | -8704 | -8551 |
| RPS17 | -8928 | -8254 |
| RPS14 | -8637 | -8513 |
| RPS21 | -8855 | -8303 |
| EIF3L | -8813 | -8228 |
| EIF3B | -7620 | -9498 |
| RPS7 | -7874 | -9137 |
| RPS11 | -8743 | -7948 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EIF1AX | 1081 | -8356 | 3339 |
| EIF2S1 | 4235 | -1636 | 6996 |
| EIF2S2 | 6091 | 549 | 7102 |
| EIF2S3 | 6653 | 2481 | 4095 |
| EIF3A | 2132 | -1264 | -723 |
| EIF3B | -7776 | -9498 | -7620 |
| EIF3C | 285 | -4694 | -8882 |
| EIF3D | 2605 | -5135 | -7554 |
| EIF3E | 1902 | -9021 | 1399 |
| EIF3F | 970 | -5176 | -8803 |
| EIF3G | 871 | -2729 | -8872 |
| EIF3H | 4677 | -7066 | -6135 |
| EIF3I | 4649 | -2563 | -8353 |
| EIF3J | 1885 | -6423 | 9055 |
| EIF3K | 1468 | -2354 | -7325 |
| EIF3L | 2560 | -8228 | -8813 |
| EIF3M | 4533 | -6792 | 3750 |
| EIF4A1 | 7476 | 5489 | -4905 |
| EIF4A2 | -10809 | -9565 | 7689 |
| EIF4B | 1237 | -8163 | -7131 |
| EIF4E | 4757 | 1648 | 9908 |
| EIF4G1 | 7908 | 10325 | -6629 |
| EIF4H | 7634 | 7669 | -8926 |
| EIF5 | 2162 | 2911 | 7027 |
| FAU | -359 | -3599 | -8841 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
Trafficking of GluR2-containing AMPA receptors
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.000828 |
| p.adjustMANOVA | 0.00251 |
| s.dist | 0.816 |
| s.t0_v_pod | 0.469 |
| s.pod_crp | 0.446 |
| s.t0_crp | -0.497 |
| p.t0_v_pod | 0.00491 |
| p.pod_crp | 0.00746 |
| p.t0_crp | 0.00288 |
| Gene | t0_crp | t0_v_pod |
|---|---|---|
| AP2M1 | -8821 | 8486 |
| AP2S1 | -7630 | 7903 |
| AP2A2 | -6585 | 7150 |
| AP2A1 | -6175 | 6737 |
| NSF | -4591 | 8683 |
| PRKCB | -4547 | 6993 |
| PICK1 | -6801 | 3562 |
| TSPAN7 | -2508 | 6381 |
| PRKCA | -4303 | 1123 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AP2A1 | 6737 | 11125 | -6175 |
| AP2A2 | 7150 | 10047 | -6585 |
| AP2B1 | -2641 | 2884 | -1439 |
| AP2M1 | 8486 | 8674 | -8821 |
| AP2S1 | 7903 | 7940 | -7630 |
| GRIA4 | -97 | 5446 | 8979 |
| GRIP1 | -10075 | -9691 | 585 |
| NSF | 8683 | 9705 | -4591 |
| PICK1 | 3562 | 6662 | -6801 |
| PRKCA | 1123 | -2393 | -4303 |
| PRKCB | 6993 | 8456 | -4547 |
| TSPAN7 | 6381 | 5014 | -2508 |
Josephin domain DUBs
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.000895 |
| p.adjustMANOVA | 0.00269 |
| s.dist | 0.815 |
| s.t0_v_pod | 0.47 |
| s.pod_crp | 0.227 |
| s.t0_crp | -0.627 |
| p.t0_v_pod | 0.0101 |
| p.pod_crp | 0.214 |
| p.t0_crp | 0.000599 |
| Gene | t0_crp | t0_v_pod |
|---|---|---|
| JOSD2 | -8493 | 7810 |
| VCP | -7331 | 6789 |
| UBB | -6697 | 6548 |
| RAD23B | -4784 | 8738 |
| RAD23A | -5237 | 6424 |
| UBC | -4003 | 4395 |
| UBA52 | -8207 | 1112 |
| JOSD1 | -4309 | 225 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATXN3 | 1588 | -665 | 7310 |
| JOSD1 | 225 | 5145 | -4309 |
| JOSD2 | 7810 | 9762 | -8493 |
| RAD23A | 6424 | 3997 | -5237 |
| RAD23B | 8738 | 9953 | -4784 |
| RPS27A | -6700 | -9695 | -8668 |
| UBA52 | 1112 | -3471 | -8207 |
| UBB | 6548 | 1016 | -6697 |
| UBC | 4395 | 6071 | -4003 |
| VCP | 6789 | 7704 | -7331 |
Influenza Viral RNA Transcription and Replication
| metric | value |
|---|---|
| setSize | 135 |
| pMANOVA | 7.99e-56 |
| p.adjustMANOVA | 4.94e-54 |
| s.dist | 0.811 |
| s.t0_v_pod | -0.225 |
| s.pod_crp | -0.573 |
| s.t0_crp | -0.529 |
| p.t0_v_pod | 6.45e-06 |
| p.pod_crp | 1.21e-30 |
| p.t0_crp | 2.39e-26 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
| RPS5 | -9014 | -8342 |
| RPL18A | -8868 | -8439 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AAAS | -8101 | -3313 | -2106 |
| DNAJC3 | 8302 | 9670 | 4528 |
| FAU | -359 | -3599 | -8841 |
| GRSF1 | 5110 | -2905 | 1530 |
| GTF2F1 | 4893 | 6665 | -7408 |
| GTF2F2 | 5371 | 6192 | 438 |
| HSP90AA1 | 1316 | -3995 | 7175 |
| IPO5 | -10252 | -10100 | -1600 |
| NDC1 | -11812 | -10048 | 3076 |
| NUP107 | -10085 | -8258 | 10051 |
| NUP133 | -7491 | -5322 | 4290 |
| NUP153 | -6108 | 252 | 4792 |
| NUP155 | -9900 | -7036 | 7468 |
| NUP160 | -10219 | -8330 | 7352 |
| NUP188 | -11270 | -7926 | -3035 |
| NUP205 | -10971 | -7490 | 2507 |
| NUP210 | -10384 | -3928 | -3875 |
| NUP214 | 7800 | 9957 | -379 |
| NUP35 | -10272 | -9698 | 3192 |
| NUP37 | 3049 | -2260 | 1416 |
| NUP42 | -5378 | -4024 | 11148 |
| NUP43 | -9198 | -8341 | 11362 |
| NUP50 | 4476 | 2618 | 7485 |
| NUP54 | -8189 | -7106 | 12095 |
| NUP58 | 8674 | 9426 | 5938 |
| NUP62 | 763 | -2395 | -4223 |
| NUP85 | -2971 | -3408 | 2948 |
| NUP88 | -11046 | -9640 | 5761 |
| NUP93 | -11266 | -6433 | 6407 |
| NUP98 | 3075 | 5814 | 2773 |
| PARP1 | -11409 | -8364 | -1542 |
| POLR2A | -3010 | 7751 | -1889 |
| POLR2B | -2462 | -3365 | 1497 |
| POLR2C | 1603 | -488 | -4803 |
| POLR2D | -3902 | -6831 | 4997 |
| POLR2E | 7450 | 5062 | -8755 |
| POLR2F | 4555 | 4218 | -8409 |
| POLR2G | 3477 | 4138 | -8391 |
| POLR2H | -2867 | -6175 | -6959 |
| POLR2I | 394 | -3908 | -8198 |
| POLR2J | 6580 | 5544 | -7980 |
| POLR2K | -1750 | -4885 | 7558 |
| POLR2L | 5244 | 2000 | -9013 |
| POM121 | -8013 | -140 | -3047 |
| POM121C | -6940 | -1697 | -6610 |
| RAE1 | 5105 | 4962 | 4462 |
| RANBP2 | -814 | -1130 | 7725 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SEC13 | 5675 | 7411 | -5667 |
| SEH1L | -5868 | -9546 | 7736 |
| TPR | -6786 | -3724 | 8739 |
| UBA52 | 1112 | -3471 | -8207 |
PD-1 signaling
| metric | value |
|---|---|
| setSize | 28 |
| pMANOVA | 4.9e-07 |
| p.adjustMANOVA | 4.09e-06 |
| s.dist | 0.811 |
| s.t0_v_pod | -0.579 |
| s.pod_crp | -0.562 |
| s.t0_crp | -0.0759 |
| p.t0_v_pod | 1.13e-07 |
| p.pod_crp | 2.6e-07 |
| p.t0_crp | 0.487 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| LCK | -11482 | -9528 |
| TRBC1 | -11646 | -9275 |
| TRAC | -11130 | -9675 |
| HLA-DRA | -11649 | -8978 |
| CD247 | -11982 | -8713 |
| CD3E | -10952 | -9221 |
| TRBV12-3 | -10099 | -9942 |
| HLA-DPB1 | -11887 | -8370 |
| HLA-DPA1 | -11954 | -8190 |
| CD3D | -11049 | -8270 |
| CD3G | -11173 | -8084 |
| TRAV19 | -9587 | -9220 |
| HLA-DQB2 | -9085 | -9628 |
| TRAV29DV5 | -9353 | -9250 |
| TRBV7-9 | -9220 | -8276 |
| HLA-DQA1 | -11633 | -6364 |
| CD274 | -7301 | -7868 |
| HLA-DQA2 | -4652 | -8746 |
| PDCD1 | -6559 | -5492 |
| CD4 | -5228 | -6856 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CD247 | -11982 | -8713 | -6364 |
| CD274 | -7301 | -7868 | 10440 |
| CD3D | -11049 | -8270 | 2178 |
| CD3E | -10952 | -9221 | 5038 |
| CD3G | -11173 | -8084 | 8697 |
| CD4 | -5228 | -6856 | -6272 |
| CSK | 5158 | 9258 | -7001 |
| HLA-DPA1 | -11954 | -8190 | 4347 |
| HLA-DPB1 | -11887 | -8370 | -2273 |
| HLA-DQA1 | -11633 | -6364 | 10152 |
| HLA-DQA2 | -4652 | -8746 | -8618 |
| HLA-DQB1 | -6199 | -4437 | 3070 |
| HLA-DQB2 | -9085 | -9628 | -6796 |
| HLA-DRA | -11649 | -8978 | 726 |
| HLA-DRB1 | -7792 | -330 | 8671 |
| HLA-DRB5 | -4806 | 741 | 5896 |
| LCK | -11482 | -9528 | -3384 |
| PDCD1 | -6559 | -5492 | -7034 |
| PDCD1LG2 | -3235 | 271 | 9937 |
| PTPN11 | 5253 | 6456 | 949 |
| PTPN6 | 6014 | 10265 | -797 |
| TRAC | -11130 | -9675 | 7034 |
| TRAV19 | -9587 | -9220 | -3070 |
| TRAV29DV5 | -9353 | -9250 | -1621 |
| TRAV8-4 | -7010 | -4747 | 11211 |
| TRBC1 | -11646 | -9275 | 1902 |
| TRBV12-3 | -10099 | -9942 | -8483 |
| TRBV7-9 | -9220 | -8276 | -4880 |
Neutrophil degranulation
| metric | value |
|---|---|
| setSize | 458 |
| pMANOVA | 1.1e-119 |
| p.adjustMANOVA | 1.5e-116 |
| s.dist | 0.809 |
| s.t0_v_pod | 0.586 |
| s.pod_crp | 0.454 |
| s.t0_crp | -0.326 |
| p.t0_v_pod | 2.13e-103 |
| p.pod_crp | 1.37e-62 |
| p.t0_crp | 5.89e-33 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| IDH1 | 9345 | 11201 |
| SIRPA | 9348 | 11197 |
| CR1 | 9325 | 11185 |
| MCEMP1 | 9342 | 11134 |
| DOK3 | 9228 | 11223 |
| HK3 | 9225 | 11211 |
| HP | 9293 | 11099 |
| GNS | 9200 | 11194 |
| SIGLEC9 | 9223 | 11166 |
| S100A12 | 9352 | 10996 |
| CTSD | 9272 | 11084 |
| RNASE2 | 9344 | 10982 |
| ATP6V0A1 | 9262 | 11071 |
| S100A8 | 9341 | 10975 |
| TIMP2 | 9297 | 11004 |
| ITGAM | 9238 | 11057 |
| QSOX1 | 9140 | 11154 |
| CD63 | 9129 | 11140 |
| CTSB | 9204 | 11040 |
| NCSTN | 9030 | 11232 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| A1BG | 5492 | -1455 | -9006 |
| ABCA13 | 4715 | -6909 | -3146 |
| ACAA1 | 8162 | 10869 | -5822 |
| ACLY | 5100 | 10091 | -439 |
| ACTR10 | 7490 | 5826 | 4427 |
| ACTR1B | -10176 | -5928 | -7545 |
| ACTR2 | 7750 | 8769 | 5308 |
| ADAM10 | 8645 | 9824 | 976 |
| ADAM8 | 5565 | 8811 | -6126 |
| ADGRE3 | 403 | 1228 | -5005 |
| ADGRE5 | -2508 | 8810 | -4306 |
| ADGRG3 | 8074 | 10815 | 2235 |
| AGA | -4482 | -7647 | -8525 |
| AGL | -3052 | 314 | 9307 |
| AGPAT2 | 9099 | 10848 | -8544 |
| ALAD | 8376 | 10268 | -6627 |
| ALDH3B1 | 8521 | 10856 | -2824 |
| ALDOA | 9092 | 10672 | -7000 |
| ALDOC | -3342 | -5589 | 1109 |
| ALOX5 | 8850 | 10969 | -3729 |
| AMPD3 | 8588 | 10009 | -5478 |
| ANO6 | 7924 | 3373 | -3706 |
| ANPEP | 9190 | 11017 | -5152 |
| ANXA2 | 8405 | 10514 | -659 |
| AOC1 | 6421 | 2487 | -8769 |
| AP1M1 | 6619 | 9444 | -8556 |
| AP2A2 | 7150 | 10047 | -6585 |
| APAF1 | 8863 | 8697 | 1510 |
| APEH | 989 | 4901 | -7164 |
| APRT | -2695 | -7554 | -8911 |
| ARG1 | 8615 | 9890 | -1331 |
| ARHGAP9 | 6170 | 9546 | -7133 |
| ARL8A | 8119 | 9885 | -8707 |
| ARMC8 | 6310 | 4556 | 4444 |
| ARPC5 | 8544 | 9930 | 1879 |
| ARSA | 3455 | 8337 | 2766 |
| ARSB | 7459 | 9871 | 1891 |
| ASAH1 | 8390 | 10601 | 3560 |
| ATAD3B | -9747 | -8327 | -4100 |
| ATG7 | 8007 | 6018 | -5002 |
| ATP11A | 8262 | 10596 | -2465 |
| ATP11B | 5982 | 8404 | 4128 |
| ATP6AP2 | 7911 | 4871 | -616 |
| ATP6V0A1 | 9262 | 11071 | -4129 |
| ATP6V0C | 8974 | 10793 | -5635 |
| ATP6V1D | 8894 | 9815 | 2539 |
| ATP8A1 | -11486 | -9190 | 1368 |
| ATP8B4 | 6869 | 5203 | -3317 |
| AZU1 | 5442 | -9352 | -7594 |
| B2M | -6684 | -6918 | 6987 |
| B4GALT1 | 4248 | 7664 | -6063 |
| BIN2 | 5672 | 9564 | -6866 |
| BPI | 6575 | -5386 | -5701 |
| BRI3 | 8865 | 10760 | -6047 |
| BST1 | 9319 | 10460 | -4980 |
| BST2 | -7131 | -773 | 6780 |
| C3 | -11900 | -3375 | 4028 |
| C3AR1 | 7890 | 11082 | 11718 |
| C5AR1 | 8976 | 10855 | -5364 |
| C6orf120 | 6106 | 6765 | -1488 |
| CAB39 | 8146 | 9237 | -1402 |
| CAMP | 4730 | -8389 | -5922 |
| CAND1 | -6331 | -7033 | 6832 |
| CANT1 | 7591 | 9121 | -3707 |
| CAP1 | 7984 | 9767 | -3179 |
| CAPN1 | 8424 | 10386 | -7700 |
| CAT | 8970 | 9931 | -691 |
| CCT2 | -8525 | -9995 | 2579 |
| CCT8 | 6464 | -2734 | -1857 |
| CD14 | 8944 | 9321 | -7666 |
| CD177 | 2440 | 10861 | -7286 |
| CD300A | -2090 | 10182 | 8407 |
| CD33 | 7944 | 6852 | -2431 |
| CD36 | 9283 | 10747 | -147 |
| CD44 | 8201 | 9117 | -5995 |
| CD47 | -11753 | -9136 | 9265 |
| CD53 | 7764 | 10130 | -1874 |
| CD55 | 8991 | 10715 | -1801 |
| CD58 | 6556 | 9534 | 7069 |
| CD59 | 5783 | 4214 | -5137 |
| CD63 | 9129 | 11140 | -8819 |
| CD68 | 8394 | 10363 | -4426 |
| CD93 | 9335 | 10737 | -7812 |
| CDA | 9152 | 10663 | -6623 |
| CDK13 | -8104 | 2102 | 313 |
| CEACAM1 | 8296 | 8922 | 4645 |
| CEACAM3 | 6743 | 10732 | 9607 |
| CEACAM6 | 4464 | -8250 | -4308 |
| CEACAM8 | 4898 | -7520 | -4626 |
| CEP290 | -8867 | -8129 | 11979 |
| CFD | 1971 | 458 | -1136 |
| CFP | 7333 | 8749 | -7816 |
| CHI3L1 | -645 | -5737 | 1602 |
| CHIT1 | 5931 | -1877 | -3573 |
| CKAP4 | 9210 | 10623 | -4859 |
| CLEC12A | 4490 | 2312 | 4243 |
| CLEC4C | -11454 | 2201 | 5124 |
| CLEC4D | 9029 | 10217 | 651 |
| CLEC5A | 8339 | 8368 | -3929 |
| CMTM6 | 7771 | 8833 | 6791 |
| CNN2 | 6554 | 9009 | -1280 |
| COMMD3 | -1344 | -2640 | 4398 |
| COMMD9 | 7845 | 7070 | -1283 |
| COPB1 | 7213 | 7893 | 6691 |
| COTL1 | 7812 | 10155 | -1806 |
| CPNE1 | -3302 | -1619 | -6859 |
| CPNE3 | 5796 | 2958 | 652 |
| CPPED1 | 8225 | 9823 | -674 |
| CR1 | 9325 | 11185 | -4186 |
| CRACR2A | -8758 | 1203 | -3907 |
| CREG1 | 9322 | 8569 | -7750 |
| CRISP3 | 7439 | 1404 | -774 |
| CRISPLD2 | 8953 | 10618 | -1904 |
| CSNK2B | 3930 | 5816 | -2975 |
| CST3 | 2193 | 1733 | -2734 |
| CSTB | 6806 | 9334 | -3641 |
| CTSA | 9351 | 10646 | -7182 |
| CTSB | 9204 | 11040 | -5546 |
| CTSC | 2312 | 9136 | 1722 |
| CTSD | 9272 | 11084 | -8465 |
| CTSG | 5056 | -9475 | -7645 |
| CTSH | 6273 | 4941 | -6379 |
| CTSS | 8240 | 6436 | 2971 |
| CTSZ | 8825 | 9776 | -7490 |
| CXCL1 | 5749 | 6987 | 4091 |
| CXCR1 | 6768 | 9194 | 6911 |
| CXCR2 | 5785 | 6647 | 6291 |
| CYB5R3 | 8753 | 10581 | -7650 |
| CYBA | 6822 | 9999 | -7207 |
| CYBB | 8879 | 9506 | 1575 |
| CYFIP1 | 9108 | 10239 | -6102 |
| CYSTM1 | 8924 | 10420 | -5096 |
| DBNL | 7633 | 9654 | -7933 |
| DDOST | 6831 | 8345 | -8761 |
| DDX3X | 6524 | 1679 | -1993 |
| DEFA1 | 5979 | -7653 | -7167 |
| DEFA4 | 5976 | -7696 | -6681 |
| DEGS1 | 6085 | 3108 | -2810 |
| DERA | 8364 | 9203 | 5762 |
| DGAT1 | 5245 | 5124 | -7354 |
| DIAPH1 | -848 | 7043 | -2195 |
| DNAJC13 | 8133 | 9754 | 8263 |
| DNAJC3 | 8302 | 9670 | 4528 |
| DNAJC5 | 8537 | 10191 | -7582 |
| DNASE1L1 | 8491 | 11170 | -4686 |
| DOCK2 | 7609 | 9981 | -3978 |
| DOK3 | 9228 | 11223 | -3807 |
| DPP7 | -4437 | -5988 | -8505 |
| DSC1 | -6691 | -9602 | 1668 |
| DSN1 | -10430 | -5283 | 10410 |
| DSP | -1779 | -566 | -1774 |
| DYNC1H1 | -7417 | 1692 | -1406 |
| DYNC1LI1 | 6841 | 8160 | 7235 |
| DYNLL1 | 5873 | 1517 | -3390 |
| DYNLT1 | 4406 | 6846 | 5710 |
| EEF1A1 | -4918 | -9723 | -8179 |
| EEF2 | 304 | -6254 | -8868 |
| ELANE | 7212 | -8344 | -7334 |
| ENPP4 | -9264 | -305 | 2386 |
| EPX | -4683 | -4759 | 7154 |
| ERP44 | 6807 | 4776 | 6518 |
| FABP5 | 5940 | 7802 | 1781 |
| FAF2 | 5487 | 7491 | -1530 |
| FCAR | 8958 | 10044 | -6856 |
| FCER1G | 8004 | 11006 | -528 |
| FCGR2A | 8699 | 10289 | -8 |
| FCGR3B | 4269 | 1379 | 4683 |
| FCN1 | 8960 | 7852 | -7616 |
| FGL2 | 669 | -5991 | 7110 |
| FGR | 8344 | 11109 | -5786 |
| FOLR3 | 7339 | 2713 | -8591 |
| FPR1 | 9137 | 11011 | -4973 |
| FPR2 | 8942 | 10687 | 2047 |
| FRK | -24 | 2650 | 7579 |
| FRMPD3 | -11117 | -543 | -2992 |
| FTH1 | 4846 | 6807 | -5091 |
| FTL | 8523 | 9929 | -4319 |
| FUCA1 | 7298 | 6401 | -7341 |
| FUCA2 | 8173 | 5966 | 582 |
| GAA | 7846 | 8503 | -6546 |
| GALNS | 6998 | 8916 | -3718 |
| GCA | 9275 | 10797 | 2682 |
| GDI2 | 7175 | 6869 | 4678 |
| GGH | 6119 | 7146 | 3797 |
| GHDC | 4117 | 1837 | -6797 |
| GLA | 8430 | 10411 | -2771 |
| GLB1 | 8581 | 10042 | -4137 |
| GLIPR1 | 7623 | 4633 | 2385 |
| GM2A | 8906 | 10650 | -78 |
| GMFG | 8129 | 9300 | -5985 |
| GNS | 9200 | 11194 | -1445 |
| GOLGA7 | 4015 | 13 | 2077 |
| GPI | 6198 | 7032 | -6824 |
| GPR84 | 8980 | 10446 | -3871 |
| GRN | 9150 | 10641 | -4496 |
| GSDMD | 1942 | 368 | -5187 |
| GSN | 8605 | 10374 | -6685 |
| GSTP1 | 134 | -750 | -6981 |
| GUSB | 7607 | 10966 | -6245 |
| GYG1 | 8861 | 10677 | -6619 |
| HBB | 8901 | 6625 | 214 |
| HEBP2 | 8266 | 8439 | -4927 |
| HEXB | 8631 | 7597 | -3321 |
| HGSNAT | 1854 | -729 | -724 |
| HK3 | 9225 | 11211 | -2877 |
| HLA-A | -2510 | -5961 | -8529 |
| HLA-B | 643 | -97 | -2281 |
| HLA-C | 1010 | 2942 | -503 |
| HLA-H | -3771 | -2724 | -8250 |
| HMGB1 | -251 | -6674 | 2350 |
| HMOX2 | -11464 | -8766 | -7843 |
| HP | 9293 | 11099 | -798 |
| HPSE | 8342 | 8707 | -212 |
| HRNR | -7096 | -5064 | -5189 |
| HSP90AA1 | 1316 | -3995 | 7175 |
| HSP90AB1 | -6629 | -9144 | 1353 |
| HSPA1A | 7946 | 9200 | -6997 |
| HSPA1B | 6382 | 8681 | 4806 |
| HSPA6 | 6426 | 9521 | -4661 |
| HSPA8 | -10578 | -9101 | 3859 |
| HUWE1 | -7700 | 1206 | -252 |
| HVCN1 | 4856 | -247 | -2410 |
| IDH1 | 9345 | 11201 | 6150 |
| IGF2R | 7044 | 10313 | -7332 |
| ILF2 | -1939 | -4357 | -2170 |
| IMPDH1 | 9136 | 11090 | -5341 |
| IMPDH2 | -9588 | -10097 | -8492 |
| IQGAP1 | 8024 | 9867 | -3260 |
| IQGAP2 | 6509 | 8319 | 3083 |
| IST1 | 5786 | 8867 | 2323 |
| ITGAL | -10503 | 3613 | -516 |
| ITGAM | 9238 | 11057 | -8230 |
| ITGAV | 6022 | 7746 | 1880 |
| ITGAX | 7227 | 11021 | -1577 |
| ITGB2 | 8792 | 10665 | -8561 |
| JUP | -5176 | -2651 | 3631 |
| KCMF1 | 7749 | 8286 | -2160 |
| KCNAB2 | -101 | 6304 | -8462 |
| KPNB1 | 2414 | 5550 | 9459 |
| KRT1 | 4492 | -5241 | -8754 |
| LAIR1 | 7078 | 11064 | -2790 |
| LAMP1 | 7515 | 9556 | -8572 |
| LAMP2 | 8640 | 8904 | 3715 |
| LAMTOR1 | 9251 | 9126 | -8916 |
| LAMTOR2 | 7454 | 7902 | -8721 |
| LAMTOR3 | 7461 | 5332 | 7456 |
| LCN2 | 7639 | 2282 | -3121 |
| LGALS3 | 8608 | 9045 | -4982 |
| LILRB2 | 7933 | 11217 | -890 |
| LILRB3 | 8723 | 10252 | -7693 |
| LPCAT1 | -7171 | 7598 | -4789 |
| LRG1 | 8532 | 10590 | -5774 |
| LRMP | 435 | 6120 | 10126 |
| LRRC7 | -1927 | -336 | -2325 |
| LTA4H | 9104 | 10358 | -1769 |
| LTF | 6220 | -4442 | -4930 |
| LYZ | 7107 | -1056 | -3630 |
| MAGT1 | 2594 | 4301 | 5100 |
| MAN2B1 | 6781 | 5710 | -7800 |
| MANBA | 7276 | 7591 | 5365 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK14 | 8951 | 10908 | -1066 |
| MCEMP1 | 9342 | 11134 | -8949 |
| METTL7A | 6820 | 6645 | 6104 |
| MGAM | 8897 | 10750 | -4312 |
| MGST1 | 9321 | 9683 | -822 |
| MIF | -3748 | -7077 | -8030 |
| MLEC | 2308 | 788 | -2323 |
| MME | 909 | 688 | 2548 |
| MMP25 | 8377 | 10851 | -120 |
| MMP8 | 9075 | 8583 | -2470 |
| MMP9 | 1677 | 10720 | -6355 |
| MNDA | 9119 | 8766 | 5667 |
| MOSPD2 | 8122 | 10733 | 11765 |
| MPO | 7325 | -8236 | -7397 |
| MS4A3 | 2347 | -6976 | 6053 |
| MVP | 6950 | 8482 | -4741 |
| NAPRT | 7301 | 9959 | 189 |
| NBEAL2 | 6982 | 10552 | -3567 |
| NCKAP1L | 7557 | 11091 | 1697 |
| NCSTN | 9030 | 11232 | -1399 |
| NDUFC2 | 6011 | 5883 | -7880 |
| NEU1 | 8877 | 10875 | -617 |
| NFAM1 | 8933 | 10694 | -5991 |
| NFASC | 859 | 4318 | 7979 |
| NFKB1 | 6191 | 2835 | -2693 |
| NHLRC3 | 1266 | 4965 | 11735 |
| NIT2 | -11340 | -9124 | 7526 |
| NME2 | 1837 | -782 | -1310 |
| NPC2 | 5393 | 3297 | 956 |
| NRAS | 5302 | 4863 | 8490 |
| OLFM4 | 8580 | 7541 | -4736 |
| OLR1 | 2469 | -7594 | -895 |
| ORM1 | 7849 | 2059 | -8909 |
| ORM2 | -2501 | 560 | -2723 |
| ORMDL3 | -9667 | -6157 | -853 |
| OSCAR | 8915 | 11206 | 2637 |
| OSTF1 | 7314 | 8222 | -2867 |
| P2RX1 | 8303 | 11222 | 2987 |
| PA2G4 | -3797 | -5231 | 2149 |
| PADI2 | 9100 | 10075 | -7484 |
| PAFAH1B2 | 6842 | 5935 | 2533 |
| PDAP1 | 5831 | 8882 | -8627 |
| PDXK | 8494 | 8151 | -6347 |
| PECAM1 | 7735 | 10233 | 1119 |
| PFKL | -3189 | -3493 | -7437 |
| PGAM1 | 9274 | 10921 | -8026 |
| PGLYRP1 | 7789 | 4866 | -6404 |
| PGM1 | 5767 | 7151 | -7570 |
| PGM2 | 9185 | 10200 | -3971 |
| PGRMC1 | 7677 | -58 | -4759 |
| PIGR | -484 | 6272 | 9900 |
| PKM | 9231 | 10340 | -7599 |
| PLAC8 | 8319 | 10913 | 3690 |
| PLAU | 4847 | 3871 | -6314 |
| PLAUR | 8292 | 10309 | -3513 |
| PLD1 | 9148 | 10884 | 229 |
| PLEKHO2 | 7935 | 10847 | -971 |
| PNP | 8287 | 7938 | 3845 |
| PPBP | 5961 | -1947 | -7603 |
| PPIA | -6535 | -6473 | -6217 |
| PPIE | -8695 | -6316 | 5179 |
| PRCP | 8088 | 8399 | -2828 |
| PRDX4 | -144 | -825 | 7123 |
| PRDX6 | 8787 | 5038 | -7088 |
| PRKCD | 8856 | 10959 | -3359 |
| PRTN3 | 6667 | -9322 | -8765 |
| PSAP | 7040 | 8768 | -2863 |
| PSEN1 | 7839 | 10248 | 3387 |
| PSMA2 | 5278 | -2806 | -1833 |
| PSMA5 | -5853 | -7450 | 4304 |
| PSMB1 | 3345 | -3591 | -5724 |
| PSMB7 | 8350 | 8341 | -8652 |
| PSMC2 | 2579 | 4502 | 3881 |
| PSMC3 | 1963 | 907 | -7500 |
| PSMD1 | 7134 | 8074 | 4202 |
| PSMD11 | 6145 | 7675 | 7728 |
| PSMD12 | 6467 | 6745 | 11721 |
| PSMD13 | 5869 | 3731 | -6995 |
| PSMD14 | 2592 | 932 | 4701 |
| PSMD2 | 7300 | 8030 | -8672 |
| PSMD3 | 4569 | 4259 | -8415 |
| PSMD6 | 7726 | 7218 | -378 |
| PSMD7 | 5884 | 2068 | 2622 |
| PTAFR | 9195 | 10014 | -7596 |
| PTGES2 | -6690 | -5442 | -6883 |
| PTPN6 | 6014 | 10265 | -797 |
| PTPRB | -7344 | -4300 | -5646 |
| PTPRC | 2227 | 7917 | 8607 |
| PTPRJ | 7666 | 10161 | -5457 |
| PTPRN2 | 5122 | 4811 | -3114 |
| PTX3 | 5722 | 1554 | 5507 |
| PYCARD | 8497 | 10357 | -5026 |
| PYGB | 486 | -412 | -6731 |
| PYGL | 9257 | 10752 | -6451 |
| QPCT | 9168 | 10510 | -4766 |
| QSOX1 | 9140 | 11154 | -8086 |
| RAB10 | 8776 | 10755 | 1116 |
| RAB14 | 6991 | 5417 | 7340 |
| RAB18 | 7683 | 6954 | 7861 |
| RAB24 | 5293 | 9481 | 4480 |
| RAB27A | 8279 | 9475 | 3475 |
| RAB31 | 9196 | 10473 | 2382 |
| RAB37 | -11438 | -1046 | 2472 |
| RAB3A | 8006 | 6219 | -8039 |
| RAB3D | 9051 | 10488 | -3922 |
| RAB44 | 567 | -3404 | -1019 |
| RAB4B | 3111 | 8330 | -6106 |
| RAB5B | 6599 | 8142 | -4226 |
| RAB5C | 8513 | 9699 | -8329 |
| RAB6A | 8020 | 9791 | 6218 |
| RAB7A | 8598 | 9942 | -5117 |
| RAB9B | -6329 | -4156 | 4841 |
| RAC1 | 8647 | 10438 | 3441 |
| RAP1A | 7198 | 7246 | 9059 |
| RAP1B | 3179 | 6882 | 6183 |
| RAP2B | -765 | 3879 | -1790 |
| RAP2C | 4551 | 7501 | 6549 |
| RETN | 8848 | 10541 | -4059 |
| RHOA | 8188 | 9259 | -372 |
| RHOF | -11981 | -8651 | -3351 |
| RHOG | 8352 | 10449 | -6499 |
| RNASE2 | 9344 | 10982 | 1974 |
| RNASE3 | 7359 | -367 | -3193 |
| RNASET2 | 5844 | 7859 | -2853 |
| ROCK1 | 7377 | 8572 | 9620 |
| S100A11 | 8796 | 10711 | -1731 |
| S100A12 | 9352 | 10996 | -7985 |
| S100A8 | 9341 | 10975 | -5317 |
| S100A9 | 9353 | 10428 | -7018 |
| S100P | 8199 | 9751 | -6386 |
| SCAMP1 | 1855 | -7288 | 5386 |
| SDCBP | 9153 | 9780 | 406 |
| SELL | 8762 | 9807 | 1921 |
| SERPINA1 | 9013 | 11191 | 4539 |
| SERPINB1 | 9273 | 10874 | -2564 |
| SERPINB10 | 8783 | 5575 | 278 |
| SERPINB6 | 5778 | 5230 | -8063 |
| SIGLEC14 | 5028 | 5607 | -2429 |
| SIGLEC5 | 8033 | 9099 | -2695 |
| SIGLEC9 | 9223 | 11166 | -6231 |
| SIRPA | 9348 | 11197 | -7771 |
| SIRPB1 | 7723 | 7051 | -7813 |
| SLC11A1 | 9014 | 11243 | -1476 |
| SLC15A4 | 3690 | 10495 | 5525 |
| SLC27A2 | -3718 | -6253 | 10610 |
| SLC2A3 | 8869 | 10524 | -5904 |
| SLC2A5 | 2031 | -6454 | 1585 |
| SLC44A2 | 2678 | 5131 | -6555 |
| SLCO4C1 | 3185 | 8367 | 5198 |
| SLPI | 5237 | -3373 | 2979 |
| SNAP23 | 8487 | 7435 | 3626 |
| SNAP29 | 6302 | 9024 | -8052 |
| SPTAN1 | -11074 | -9433 | -5265 |
| SRP14 | 6234 | 4977 | 998 |
| STBD1 | 5477 | 5608 | -1804 |
| STING1 | 4736 | 93 | -6182 |
| STK10 | -3780 | 8865 | -5028 |
| STK11IP | 3554 | 8746 | -8134 |
| STOM | 6613 | 7887 | 1218 |
| SURF4 | 6954 | 8190 | -6777 |
| SVIP | 2022 | -3033 | 4377 |
| SYNGR1 | -4479 | 844 | -4339 |
| TARM1 | 5246 | 3916 | 749 |
| TBC1D10C | -11505 | -7582 | -7751 |
| TCIRG1 | 7082 | 10931 | -5721 |
| TCN1 | 6098 | -1695 | 692 |
| TICAM2 | 6249 | 4224 | 8248 |
| TIMP2 | 9297 | 11004 | -6123 |
| TLR2 | 8950 | 10352 | 3541 |
| TMBIM1 | 8229 | 10023 | -7768 |
| TMC6 | -10267 | -6526 | -2845 |
| TMEM179B | 443 | -1658 | -1392 |
| TMEM30A | 7913 | 6946 | 4350 |
| TMEM63A | -8824 | -7951 | 3518 |
| TNFAIP6 | 8594 | 10371 | 2110 |
| TNFRSF1B | 5964 | 9907 | -4810 |
| TOLLIP | 8432 | 9528 | -8125 |
| TOM1 | 9044 | 10410 | -8578 |
| TRAPPC1 | 7688 | 8957 | -5965 |
| TRPM2 | 8949 | 10927 | -7268 |
| TSPAN14 | 6870 | 10567 | -3835 |
| TUBB | -6718 | -1662 | -584 |
| TUBB4B | 7133 | 8322 | -3933 |
| TXNDC5 | 391 | -2127 | 9431 |
| TYROBP | 7427 | 9484 | -6868 |
| UBR4 | -2044 | 6523 | 1736 |
| UNC13D | 7492 | 11054 | -5971 |
| VAMP8 | 5157 | -137 | -8777 |
| VAPA | 8881 | 9482 | 555 |
| VAT1 | 9118 | 10769 | -8358 |
| VCL | 7218 | 6129 | -4751 |
| VCP | 6789 | 7704 | -7331 |
| VNN1 | 8939 | 10798 | -327 |
| VPS35L | 6034 | 9179 | 4071 |
| XRCC5 | 5322 | 1817 | 1094 |
| XRCC6 | -4326 | -8119 | -5161 |
| YPEL5 | 6593 | 7201 | 3811 |
Major pathway of rRNA processing in the nucleolus and cytosol
| metric | value |
|---|---|
| setSize | 180 |
| pMANOVA | 2.04e-68 |
| p.adjustMANOVA | 1.73e-66 |
| s.dist | 0.808 |
| s.t0_v_pod | -0.306 |
| s.pod_crp | -0.637 |
| s.t0_crp | -0.391 |
| p.t0_v_pod | 1.3e-12 |
| p.pod_crp | 1.75e-49 |
| p.t0_crp | 1.36e-19 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| FBL | -9913 | -8826 |
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| WDR46 | -9028 | -8694 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BMS1 | -11315 | -9598 | -1337 |
| BOP1 | -5039 | -6568 | -8304 |
| BYSL | -4316 | -4876 | -6332 |
| C1D | 3484 | -321 | 11355 |
| CSNK1D | 2374 | 8356 | -7947 |
| CSNK1E | -9964 | -6501 | -4870 |
| DCAF13 | -5386 | -7538 | -2062 |
| DDX21 | 3087 | -1187 | 8531 |
| DDX47 | -10949 | -9306 | 8082 |
| DDX49 | 4816 | 4046 | -8272 |
| DDX52 | 448 | 1780 | 12323 |
| DHX37 | -7983 | -4720 | -3600 |
| DIS3 | -4187 | -4119 | 11534 |
| EBNA1BP2 | -3970 | -7889 | -588 |
| EMG1 | -9856 | -8716 | 8730 |
| ERI1 | 5474 | 6607 | 11232 |
| EXOSC1 | -979 | -487 | 5176 |
| EXOSC10 | -11028 | -6804 | 6476 |
| EXOSC2 | -10724 | -9725 | -4656 |
| EXOSC3 | 503 | -40 | 4327 |
| EXOSC4 | 7485 | 9870 | -6235 |
| EXOSC5 | -4428 | -8367 | -7087 |
| EXOSC6 | -9514 | -7432 | -3150 |
| EXOSC7 | -10290 | -8445 | -8729 |
| EXOSC8 | -11104 | -9351 | 7169 |
| EXOSC9 | -9917 | -8765 | 10776 |
| FAU | -359 | -3599 | -8841 |
| FBL | -9855 | -9913 | -8826 |
| FCF1 | 4428 | 450 | 6199 |
| FTSJ3 | -3900 | -1188 | -3676 |
| GNL3 | -8199 | -9931 | 4303 |
| HEATR1 | -10009 | -7253 | 5481 |
| IMP3 | -9143 | -6887 | -5060 |
| IMP4 | -10629 | -7130 | -5576 |
| ISG20L2 | 3737 | 3123 | 6401 |
| KRR1 | -8329 | -7693 | 8202 |
| LAS1L | -11905 | -9651 | -4481 |
| LTV1 | -4162 | -7094 | 5542 |
| MPHOSPH10 | -7519 | -8812 | 11917 |
| MPHOSPH6 | 2168 | -3175 | 1284 |
| MTREX | -2574 | -4473 | 5717 |
| NCL | -8953 | -9308 | -4346 |
| NIP7 | -5682 | -7752 | 4552 |
| NOB1 | -9986 | -8880 | -5059 |
| NOC4L | -5298 | 1593 | 234 |
| NOL11 | -10134 | -9903 | 8964 |
| NOL12 | 4887 | 4239 | -4051 |
| NOL6 | -10564 | -7807 | -3599 |
| NOL9 | -9891 | -8758 | 9241 |
| NOP14 | -10522 | -9613 | -4168 |
| NOP56 | -11395 | -9416 | 246 |
| NOP58 | -9623 | -10002 | 8617 |
| PDCD11 | -11166 | -6522 | -2344 |
| PELP1 | -10584 | -8205 | -1289 |
| PES1 | -1993 | -7123 | -8715 |
| PNO1 | -6627 | -7977 | 9345 |
| PWP2 | -1190 | -5399 | -7041 |
| RBM28 | -11316 | -5688 | 1861 |
| RCL1 | -751 | -7663 | -1012 |
| RIOK1 | -3702 | -4836 | 2397 |
| RIOK2 | 927 | -8052 | 9706 |
| RIOK3 | 8621 | 7003 | 9886 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPP14 | 2981 | -2190 | 7808 |
| RPP21 | -5178 | -4239 | -7477 |
| RPP25 | -7963 | -8660 | -2890 |
| RPP30 | -7818 | -8612 | 8067 |
| RPP38 | -6833 | -7656 | 6479 |
| RPP40 | -4680 | -10040 | 3381 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| RRP1 | -3003 | -3032 | 2020 |
| RRP36 | -1645 | -390 | -5014 |
| RRP7A | -2734 | -5222 | -4553 |
| RRP9 | -9748 | -8570 | -7939 |
| SENP3 | 2970 | 77 | -3111 |
| SNORD3A | -2477 | 10412 | 10967 |
| SNU13 | -6637 | -8467 | -6973 |
| TBL3 | -3341 | 732 | -6317 |
| TEX10 | -9440 | -8887 | 11517 |
| TSR1 | -9409 | -9696 | 4264 |
| UBA52 | 1112 | -3471 | -8207 |
| UTP11 | 4582 | -37 | 6683 |
| UTP14A | -1788 | -3304 | 3687 |
| UTP14C | -2032 | -2400 | 5261 |
| UTP15 | -10264 | -9128 | 11648 |
| UTP18 | 5055 | 3815 | 4880 |
| UTP20 | -10191 | -7402 | 9700 |
| UTP3 | -2829 | -4799 | -4079 |
| UTP4 | -11142 | -9672 | 3675 |
| UTP6 | -4362 | -8588 | 8987 |
| WDR12 | 5156 | -723 | 7083 |
| WDR18 | -2260 | -3796 | -3450 |
| WDR3 | -6394 | -6991 | 570 |
| WDR36 | -3825 | -5050 | 5877 |
| WDR43 | -7419 | -9367 | 167 |
| WDR46 | -10623 | -9028 | -8694 |
| WDR75 | -9593 | -9795 | 7835 |
| XRN2 | 9240 | 10090 | -4182 |
rRNA processing in the nucleus and cytosol
| metric | value |
|---|---|
| setSize | 190 |
| pMANOVA | 2.79e-71 |
| p.adjustMANOVA | 3.17e-69 |
| s.dist | 0.806 |
| s.t0_v_pod | -0.307 |
| s.pod_crp | -0.633 |
| s.t0_crp | -0.393 |
| p.t0_v_pod | 2.77e-13 |
| p.pod_crp | 2.17e-51 |
| p.t0_crp | 9.47e-21 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| FBL | -9913 | -8826 |
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| WDR46 | -9028 | -8694 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BMS1 | -11315 | -9598 | -1337 |
| BOP1 | -5039 | -6568 | -8304 |
| BYSL | -4316 | -4876 | -6332 |
| C1D | 3484 | -321 | 11355 |
| CSNK1D | 2374 | 8356 | -7947 |
| CSNK1E | -9964 | -6501 | -4870 |
| DCAF13 | -5386 | -7538 | -2062 |
| DDX21 | 3087 | -1187 | 8531 |
| DDX47 | -10949 | -9306 | 8082 |
| DDX49 | 4816 | 4046 | -8272 |
| DDX52 | 448 | 1780 | 12323 |
| DHX37 | -7983 | -4720 | -3600 |
| DIMT1 | -7711 | -9624 | 8995 |
| DIS3 | -4187 | -4119 | 11534 |
| DKC1 | -11282 | -10110 | -3751 |
| EBNA1BP2 | -3970 | -7889 | -588 |
| EMG1 | -9856 | -8716 | 8730 |
| ERI1 | 5474 | 6607 | 11232 |
| EXOSC1 | -979 | -487 | 5176 |
| EXOSC10 | -11028 | -6804 | 6476 |
| EXOSC2 | -10724 | -9725 | -4656 |
| EXOSC3 | 503 | -40 | 4327 |
| EXOSC4 | 7485 | 9870 | -6235 |
| EXOSC5 | -4428 | -8367 | -7087 |
| EXOSC6 | -9514 | -7432 | -3150 |
| EXOSC7 | -10290 | -8445 | -8729 |
| EXOSC8 | -11104 | -9351 | 7169 |
| EXOSC9 | -9917 | -8765 | 10776 |
| FAU | -359 | -3599 | -8841 |
| FBL | -9855 | -9913 | -8826 |
| FCF1 | 4428 | 450 | 6199 |
| FTSJ3 | -3900 | -1188 | -3676 |
| GAR1 | -6703 | -7382 | 238 |
| GNL3 | -8199 | -9931 | 4303 |
| HEATR1 | -10009 | -7253 | 5481 |
| IMP3 | -9143 | -6887 | -5060 |
| IMP4 | -10629 | -7130 | -5576 |
| ISG20L2 | 3737 | 3123 | 6401 |
| KRR1 | -8329 | -7693 | 8202 |
| LAS1L | -11905 | -9651 | -4481 |
| LTV1 | -4162 | -7094 | 5542 |
| MPHOSPH10 | -7519 | -8812 | 11917 |
| MPHOSPH6 | 2168 | -3175 | 1284 |
| MTREX | -2574 | -4473 | 5717 |
| NAT10 | -11593 | -9800 | -2380 |
| NCL | -8953 | -9308 | -4346 |
| NHP2 | -3373 | -6510 | -7363 |
| NIP7 | -5682 | -7752 | 4552 |
| NOB1 | -9986 | -8880 | -5059 |
| NOC4L | -5298 | 1593 | 234 |
| NOL11 | -10134 | -9903 | 8964 |
| NOL12 | 4887 | 4239 | -4051 |
| NOL6 | -10564 | -7807 | -3599 |
| NOL9 | -9891 | -8758 | 9241 |
| NOP10 | 8200 | 10199 | -7289 |
| NOP14 | -10522 | -9613 | -4168 |
| NOP2 | -9624 | -8280 | -6603 |
| NOP56 | -11395 | -9416 | 246 |
| NOP58 | -9623 | -10002 | 8617 |
| PDCD11 | -11166 | -6522 | -2344 |
| PELP1 | -10584 | -8205 | -1289 |
| PES1 | -1993 | -7123 | -8715 |
| PNO1 | -6627 | -7977 | 9345 |
| PWP2 | -1190 | -5399 | -7041 |
| RBM28 | -11316 | -5688 | 1861 |
| RCL1 | -751 | -7663 | -1012 |
| RIOK1 | -3702 | -4836 | 2397 |
| RIOK2 | 927 | -8052 | 9706 |
| RIOK3 | 8621 | 7003 | 9886 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPP14 | 2981 | -2190 | 7808 |
| RPP21 | -5178 | -4239 | -7477 |
| RPP25 | -7963 | -8660 | -2890 |
| RPP30 | -7818 | -8612 | 8067 |
| RPP38 | -6833 | -7656 | 6479 |
| RPP40 | -4680 | -10040 | 3381 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| RRP1 | -3003 | -3032 | 2020 |
| RRP36 | -1645 | -390 | -5014 |
| RRP7A | -2734 | -5222 | -4553 |
| RRP9 | -9748 | -8570 | -7939 |
| SENP3 | 2970 | 77 | -3111 |
| SNORD3A | -2477 | 10412 | 10967 |
| SNU13 | -6637 | -8467 | -6973 |
| TBL3 | -3341 | 732 | -6317 |
| TEX10 | -9440 | -8887 | 11517 |
| THUMPD1 | -9477 | -9754 | 7788 |
| TRMT112 | 732 | -2281 | -8647 |
| TSR1 | -9409 | -9696 | 4264 |
| TSR3 | 3808 | 1485 | -8865 |
| UBA52 | 1112 | -3471 | -8207 |
| UTP11 | 4582 | -37 | 6683 |
| UTP14A | -1788 | -3304 | 3687 |
| UTP14C | -2032 | -2400 | 5261 |
| UTP15 | -10264 | -9128 | 11648 |
| UTP18 | 5055 | 3815 | 4880 |
| UTP20 | -10191 | -7402 | 9700 |
| UTP3 | -2829 | -4799 | -4079 |
| UTP4 | -11142 | -9672 | 3675 |
| UTP6 | -4362 | -8588 | 8987 |
| WDR12 | 5156 | -723 | 7083 |
| WDR18 | -2260 | -3796 | -3450 |
| WDR3 | -6394 | -6991 | 570 |
| WDR36 | -3825 | -5050 | 5877 |
| WDR43 | -7419 | -9367 | 167 |
| WDR46 | -10623 | -9028 | -8694 |
| WDR75 | -9593 | -9795 | 7835 |
| XRN2 | 9240 | 10090 | -4182 |
Platelet sensitization by LDL
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.000633 |
| p.adjustMANOVA | 0.002 |
| s.dist | 0.798 |
| s.t0_v_pod | 0.552 |
| s.pod_crp | 0.566 |
| s.t0_crp | -0.107 |
| p.t0_v_pod | 0.000131 |
| p.pod_crp | 8.9e-05 |
| p.t0_crp | 0.458 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| MAPK14 | 10908 | 8951 |
| FGR | 11109 | 8344 |
| PLA2G4A | 9642 | 9025 |
| PECAM1 | 10233 | 7735 |
| PPP2R5B | 9746 | 6679 |
| PTPN6 | 10265 | 6014 |
| PPP2R5A | 9666 | 5821 |
| PPP2CB | 7359 | 7596 |
| PPP2CA | 6731 | 8104 |
| LRP8 | 9495 | 4522 |
| PTPN11 | 6456 | 5253 |
| PPP2R1A | 5140 | 4542 |
| PPP2R5D | 6530 | 2405 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| FGR | 8344 | 11109 | -5786 |
| LRP8 | 4522 | 9495 | -1527 |
| MAPK14 | 8951 | 10908 | -1066 |
| PECAM1 | 7735 | 10233 | 1119 |
| PLA2G4A | 9025 | 9642 | -1028 |
| PPP2CA | 8104 | 6731 | -306 |
| PPP2CB | 7596 | 7359 | 4715 |
| PPP2R1A | 4542 | 5140 | -7934 |
| PPP2R1B | -241 | 88 | 5847 |
| PPP2R5A | 5821 | 9666 | 6005 |
| PPP2R5B | 6679 | 9746 | 773 |
| PPP2R5C | -10916 | -5174 | 3373 |
| PPP2R5D | 2405 | 6530 | -1893 |
| PPP2R5E | -675 | -2578 | 5737 |
| PTPN11 | 5253 | 6456 | 949 |
| PTPN6 | 6014 | 10265 | -797 |
p130Cas linkage to MAPK signaling for integrins
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.000997 |
| p.adjustMANOVA | 0.00296 |
| s.dist | 0.798 |
| s.t0_v_pod | 0.666 |
| s.pod_crp | 0.382 |
| s.t0_crp | -0.218 |
| p.t0_v_pod | 0.000132 |
| p.pod_crp | 0.0282 |
| p.t0_crp | 0.211 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| APBB1IP | 8600 | 10436 |
| CRK | 8756 | 10207 |
| TLN1 | 8386 | 10017 |
| ITGA2B | 8744 | 7297 |
| RAP1A | 7198 | 7246 |
| VWF | 6550 | 3834 |
| ITGB3 | 8161 | 2918 |
| RAP1B | 3179 | 6882 |
| PTK2 | 4418 | 385 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| APBB1IP | 8600 | 10436 | -610 |
| CRK | 8756 | 10207 | 5223 |
| FN1 | 8154 | -1816 | 4140 |
| ITGA2B | 8744 | 7297 | -5705 |
| ITGB3 | 8161 | 2918 | -7520 |
| PTK2 | 4418 | 385 | -619 |
| RAP1A | 7198 | 7246 | 9059 |
| RAP1B | 3179 | 6882 | 6183 |
| SRC | -8520 | -6371 | -3347 |
| TLN1 | 8386 | 10017 | -6948 |
| VWF | 6550 | 3834 | -7272 |
NOTCH4 Activation and Transmission of Signal to the Nucleus
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0112 |
| p.adjustMANOVA | 0.0233 |
| s.dist | 0.797 |
| s.t0_v_pod | 0.528 |
| s.pod_crp | 0.577 |
| s.t0_crp | -0.155 |
| p.t0_v_pod | 0.00386 |
| p.pod_crp | 0.00158 |
| p.t0_crp | 0.395 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| NCSTN | 11232 | 9030 |
| ADAM10 | 9824 | 8645 |
| PSEN1 | 10248 | 7839 |
| JAG1 | 8125 | 8599 |
| APH1B | 9329 | 6194 |
| PSENEN | 7006 | 5662 |
| YWHAZ | 5153 | 5555 |
| APH1A | 2543 | 4092 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ADAM10 | 8645 | 9824 | 976 |
| APH1A | 4092 | 2543 | -8533 |
| APH1B | 6194 | 9329 | 7523 |
| JAG1 | 8599 | 8125 | -6709 |
| NCSTN | 9030 | 11232 | -1399 |
| NOTCH4 | -5056 | 10115 | 2220 |
| PSEN1 | 7839 | 10248 | 3387 |
| PSEN2 | -7449 | -6368 | -96 |
| PSENEN | 5662 | 7006 | -3411 |
| YWHAZ | 5555 | 5153 | 6004 |
Hyaluronan metabolism
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00112 |
| p.adjustMANOVA | 0.00326 |
| s.dist | 0.795 |
| s.t0_v_pod | 0.513 |
| s.pod_crp | 0.429 |
| s.t0_crp | -0.43 |
| p.t0_v_pod | 0.00137 |
| p.pod_crp | 0.00741 |
| p.t0_crp | 0.00732 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| HYAL2 | 8935 | -8015 |
| CHP1 | 9101 | -5812 |
| CD44 | 8201 | -5995 |
| GUSB | 7607 | -6245 |
| SLC9A1 | 7847 | -5759 |
| HEXB | 8631 | -3321 |
| HYAL3 | 5168 | -3394 |
| ABCC5 | 2460 | -6111 |
| HEXA | 1251 | -6759 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ABCC5 | 2460 | 1575 | -6111 |
| CD44 | 8201 | 9117 | -5995 |
| CEMIP | -7161 | -5011 | 2494 |
| CHP1 | 9101 | 9868 | -5812 |
| GUSB | 7607 | 10966 | -6245 |
| HAS3 | -5989 | 3310 | -750 |
| HEXA | 1251 | -1954 | -6759 |
| HEXB | 8631 | 7597 | -3321 |
| HMMR | 3770 | 1842 | 1914 |
| HYAL1 | 4123 | 8255 | 9608 |
| HYAL2 | 8935 | 11003 | -8015 |
| HYAL3 | 5168 | -884 | -3394 |
| SLC9A1 | 7847 | 11135 | -5759 |
Detoxification of Reactive Oxygen Species
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 3.13e-08 |
| p.adjustMANOVA | 3.27e-07 |
| s.dist | 0.792 |
| s.t0_v_pod | 0.561 |
| s.pod_crp | 0.436 |
| s.t0_crp | -0.35 |
| p.t0_v_pod | 3.93e-08 |
| p.pod_crp | 1.93e-05 |
| p.t0_crp | 0.000609 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| GSR | 9078 | 10845 |
| NCF4 | 9111 | 10617 |
| NCF2 | 9034 | 10598 |
| PRDX3 | 9206 | 10292 |
| CAT | 8970 | 9931 |
| CYBB | 8879 | 9506 |
| P4HB | 8307 | 9921 |
| ERO1A | 8793 | 9302 |
| TXNRD1 | 8062 | 9724 |
| PRDX5 | 8392 | 9127 |
| TXN | 8155 | 9128 |
| CYBA | 6822 | 9999 |
| GPX1 | 9156 | 6881 |
| NCF1 | 7224 | 7158 |
| TXNRD2 | 7414 | 6361 |
| PRDX6 | 8787 | 5038 |
| SOD2 | 4346 | 7197 |
| ATOX1 | 4294 | 6444 |
| PRDX1 | 6927 | 3767 |
| TXN2 | 4601 | 2594 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATOX1 | 4294 | 6444 | -6057 |
| ATP7A | 688 | 5910 | 1701 |
| CAT | 8970 | 9931 | -691 |
| CCS | 1525 | -1637 | -7219 |
| CYBA | 6822 | 9999 | -7207 |
| CYBB | 8879 | 9506 | 1575 |
| CYCS | -1315 | -4434 | 5135 |
| ERO1A | 8793 | 9302 | 9176 |
| GPX1 | 9156 | 6881 | -8782 |
| GPX2 | -3430 | 3337 | 8521 |
| GPX3 | 674 | 9456 | -2777 |
| GPX7 | -8599 | -8935 | -5711 |
| GSR | 9078 | 10845 | -6395 |
| GSTP1 | 134 | -750 | -6981 |
| NCF1 | 7224 | 7158 | -2796 |
| NCF2 | 9034 | 10598 | -2149 |
| NCF4 | 9111 | 10617 | -6708 |
| NOX4 | 1105 | 5673 | 9217 |
| NOX5 | 1165 | 5152 | 10464 |
| NUDT2 | 2964 | 70 | -5706 |
| P4HB | 8307 | 9921 | -7996 |
| PRDX1 | 6927 | 3767 | 3340 |
| PRDX2 | 3398 | -4018 | -5960 |
| PRDX3 | 9206 | 10292 | 2736 |
| PRDX5 | 8392 | 9127 | -8941 |
| PRDX6 | 8787 | 5038 | -7088 |
| SOD1 | -4704 | -7395 | -4250 |
| SOD2 | 4346 | 7197 | 3619 |
| TXN | 8155 | 9128 | -994 |
| TXN2 | 4601 | 2594 | -8158 |
| TXNRD1 | 8062 | 9724 | -2030 |
| TXNRD2 | 7414 | 6361 | -7504 |
Insulin receptor recycling
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 1.06e-05 |
| p.adjustMANOVA | 5.76e-05 |
| s.dist | 0.79 |
| s.t0_v_pod | 0.568 |
| s.pod_crp | 0.404 |
| s.t0_crp | -0.371 |
| p.t0_v_pod | 6.47e-06 |
| p.pod_crp | 0.00134 |
| p.t0_crp | 0.00326 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| ATP6V0A1 | 9262 | 11071 |
| ATP6V0D1 | 9088 | 10812 |
| ATP6V0C | 8974 | 10793 |
| ATP6AP1 | 8032 | 11126 |
| ATP6V1D | 8894 | 9815 |
| ATP6V1A | 9144 | 9387 |
| ATP6V1B2 | 8904 | 9293 |
| ATP6V1C1 | 8400 | 9733 |
| ATP6V0B | 8458 | 9622 |
| TCIRG1 | 7082 | 10931 |
| INSR | 8152 | 9251 |
| ATP6V0E1 | 8456 | 8299 |
| ATP6V1E1 | 7912 | 8087 |
| ATP6V1H | 7939 | 7019 |
| ATP6V1F | 5802 | 3776 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATP6AP1 | 8032 | 11126 | -8542 |
| ATP6V0A1 | 9262 | 11071 | -4129 |
| ATP6V0A2 | -11850 | -6562 | 10591 |
| ATP6V0B | 8458 | 9622 | -7822 |
| ATP6V0C | 8974 | 10793 | -5635 |
| ATP6V0D1 | 9088 | 10812 | -6200 |
| ATP6V0E1 | 8456 | 8299 | -6597 |
| ATP6V0E2 | -11202 | -9428 | 81 |
| ATP6V1A | 9144 | 9387 | 639 |
| ATP6V1B2 | 8904 | 9293 | -2076 |
| ATP6V1C1 | 8400 | 9733 | 1842 |
| ATP6V1C2 | -2175 | -2908 | 1018 |
| ATP6V1D | 8894 | 9815 | 2539 |
| ATP6V1E1 | 7912 | 8087 | 1529 |
| ATP6V1E2 | 5657 | -3873 | -6954 |
| ATP6V1F | 5802 | 3776 | -8689 |
| ATP6V1G1 | 3892 | -4753 | -2897 |
| ATP6V1G2 | -9197 | -9115 | 3143 |
| ATP6V1H | 7939 | 7019 | -2464 |
| INSR | 8152 | 9251 | -2060 |
| TCIRG1 | 7082 | 10931 | -5721 |
Activation of the pre-replicative complex
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 6.26e-08 |
| p.adjustMANOVA | 6.35e-07 |
| s.dist | 0.779 |
| s.t0_v_pod | -0.482 |
| s.pod_crp | -0.604 |
| s.t0_crp | 0.105 |
| p.t0_v_pod | 2.37e-06 |
| p.pod_crp | 3.4e-09 |
| p.t0_crp | 0.304 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| MCM3 | -9914 | -11839 |
| POLA1 | -9813 | -11789 |
| RPA1 | -9771 | -11644 |
| MCM7 | -9297 | -11768 |
| POLE3 | -9259 | -11228 |
| DBF4 | -8879 | -10581 |
| PRIM1 | -9138 | -9858 |
| POLA2 | -7923 | -11222 |
| ORC3 | -7862 | -10371 |
| MCM6 | -8603 | -9393 |
| RPA3 | -9192 | -8609 |
| ORC2 | -8229 | -9594 |
| ORC5 | -8511 | -9161 |
| POLE2 | -7736 | -9613 |
| MCM8 | -5689 | -10599 |
| MCM4 | -7061 | -8404 |
| MCM2 | -6855 | -6973 |
| PRIM2 | -7087 | -5389 |
| CDC7 | -4471 | -7583 |
| POLE | -4060 | -7317 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CDC45 | -2594 | -5110 | 1889 |
| CDC6 | 2356 | -1584 | 3684 |
| CDC7 | -7583 | -4471 | -125 |
| CDK2 | -4840 | -3595 | 835 |
| CDT1 | -285 | -3417 | -3854 |
| DBF4 | -10581 | -8879 | 10352 |
| GMNN | 1412 | 2147 | 7406 |
| MCM10 | 769 | -4565 | 4390 |
| MCM2 | -6973 | -6855 | -3428 |
| MCM3 | -11839 | -9914 | -2392 |
| MCM4 | -8404 | -7061 | 3202 |
| MCM5 | -7039 | -2312 | -5776 |
| MCM6 | -9393 | -8603 | 109 |
| MCM7 | -11768 | -9297 | -1374 |
| MCM8 | -10599 | -5689 | 7587 |
| ORC1 | -2459 | -2954 | 1035 |
| ORC2 | -9594 | -8229 | 7471 |
| ORC3 | -10371 | -7862 | 10286 |
| ORC4 | -1988 | -6242 | 8361 |
| ORC5 | -9161 | -8511 | 9855 |
| ORC6 | 1174 | 5286 | 4883 |
| POLA1 | -11789 | -9813 | 1029 |
| POLA2 | -11222 | -7923 | 8950 |
| POLE | -7317 | -4060 | 2599 |
| POLE2 | -9613 | -7736 | 11428 |
| POLE3 | -11228 | -9259 | -7832 |
| POLE4 | 5453 | -1843 | -7470 |
| PRIM1 | -9858 | -9138 | 10019 |
| PRIM2 | -5389 | -7087 | 2832 |
| RPA1 | -11644 | -9771 | -3472 |
| RPA2 | -6094 | -4789 | 4026 |
| RPA3 | -8609 | -9192 | 2284 |
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00427 |
| p.adjustMANOVA | 0.0102 |
| s.dist | 0.776 |
| s.t0_v_pod | 0.555 |
| s.pod_crp | 0.535 |
| s.t0_crp | -0.0839 |
| p.t0_v_pod | 0.000528 |
| p.pod_crp | 0.000832 |
| p.t0_crp | 0.601 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| RAC1 | 8647 | 10438 |
| CRK | 8756 | 10207 |
| RHOA | 8188 | 9259 |
| PXN | 6144 | 9961 |
| DOCK1 | 7206 | 7497 |
| PTK6 | 5877 | 9124 |
| ELMO2 | 4353 | 10016 |
| ELMO1 | 6172 | 5403 |
| NRAS | 5302 | 4863 |
| KRAS | 3668 | 6068 |
| RASA1 | 2093 | 6185 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ARHGAP35 | -3266 | -2187 | -6810 |
| CRK | 8756 | 10207 | 5223 |
| DOCK1 | 7206 | 7497 | -6177 |
| ELMO1 | 6172 | 5403 | -5996 |
| ELMO2 | 4353 | 10016 | 2305 |
| HRAS | -3288 | -5249 | -5447 |
| KRAS | 3668 | 6068 | 10842 |
| NRAS | 5302 | 4863 | 8490 |
| PTK6 | 5877 | 9124 | 607 |
| PXN | 6144 | 9961 | -7143 |
| RAC1 | 8647 | 10438 | 3441 |
| RASA1 | 2093 | 6185 | 10904 |
| RHOA | 8188 | 9259 | -372 |
ROS and RNS production in phagocytes
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 1.4e-08 |
| p.adjustMANOVA | 1.54e-07 |
| s.dist | 0.775 |
| s.t0_v_pod | 0.597 |
| s.pod_crp | 0.371 |
| s.t0_crp | -0.324 |
| p.t0_v_pod | 8.47e-09 |
| p.pod_crp | 0.000346 |
| p.t0_crp | 0.00177 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| ATP6V0A1 | 9262 | 11071 |
| SLC11A1 | 9014 | 11243 |
| ATP6V0D1 | 9088 | 10812 |
| ATP6V0C | 8974 | 10793 |
| NCF4 | 9111 | 10617 |
| NCF2 | 9034 | 10598 |
| ATP6V1D | 8894 | 9815 |
| ATP6V1A | 9144 | 9387 |
| CYBB | 8879 | 9506 |
| ATP6V1B2 | 8904 | 9293 |
| ATP6V1C1 | 8400 | 9733 |
| ATP6V0B | 8458 | 9622 |
| TCIRG1 | 7082 | 10931 |
| ATP6V0E1 | 8456 | 8299 |
| CYBA | 6822 | 9999 |
| ATP6V1E1 | 7912 | 8087 |
| ATP6V1H | 7939 | 7019 |
| NCF1 | 7224 | 7158 |
| RAC2 | 5104 | 8122 |
| ATP6V1F | 5802 | 3776 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATP6V0A1 | 9262 | 11071 | -4129 |
| ATP6V0A2 | -11850 | -6562 | 10591 |
| ATP6V0B | 8458 | 9622 | -7822 |
| ATP6V0C | 8974 | 10793 | -5635 |
| ATP6V0D1 | 9088 | 10812 | -6200 |
| ATP6V0E1 | 8456 | 8299 | -6597 |
| ATP6V0E2 | -11202 | -9428 | 81 |
| ATP6V1A | 9144 | 9387 | 639 |
| ATP6V1B2 | 8904 | 9293 | -2076 |
| ATP6V1C1 | 8400 | 9733 | 1842 |
| ATP6V1C2 | -2175 | -2908 | 1018 |
| ATP6V1D | 8894 | 9815 | 2539 |
| ATP6V1E1 | 7912 | 8087 | 1529 |
| ATP6V1E2 | 5657 | -3873 | -6954 |
| ATP6V1F | 5802 | 3776 | -8689 |
| ATP6V1G1 | 3892 | -4753 | -2897 |
| ATP6V1G2 | -9197 | -9115 | 3143 |
| ATP6V1H | 7939 | 7019 | -2464 |
| CYBA | 6822 | 9999 | -7207 |
| CYBB | 8879 | 9506 | 1575 |
| HVCN1 | 4856 | -247 | -2410 |
| LPO | 6414 | 2519 | 7391 |
| MPO | 7325 | -8236 | -7397 |
| NCF1 | 7224 | 7158 | -2796 |
| NCF2 | 9034 | 10598 | -2149 |
| NCF4 | 9111 | 10617 | -6708 |
| NOS1 | 1355 | 3987 | 9572 |
| NOS3 | -2018 | -7144 | 672 |
| RAC2 | 5104 | 8122 | -7294 |
| SLC11A1 | 9014 | 11243 | -1476 |
| TCIRG1 | 7082 | 10931 | -5721 |
Signaling by Leptin
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00824 |
| p.adjustMANOVA | 0.018 |
| s.dist | 0.768 |
| s.t0_v_pod | 0.565 |
| s.pod_crp | 0.388 |
| s.t0_crp | -0.347 |
| p.t0_v_pod | 0.00198 |
| p.pod_crp | 0.0337 |
| p.t0_crp | 0.0576 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| SOCS3 | 9315 | 10630 |
| IRS2 | 8429 | 9284 |
| STAT3 | 7972 | 9583 |
| STAT5B | 6825 | 8618 |
| STAT5A | 6864 | 7733 |
| PTPN11 | 5253 | 6456 |
| JAK2 | 2670 | 4389 |
| LEPR | 6397 | 1782 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| IRS1 | 1728 | -6009 | -4997 |
| IRS2 | 8429 | 9284 | -8471 |
| JAK2 | 2670 | 4389 | 12253 |
| LEPR | 6397 | 1782 | -3458 |
| PTPN11 | 5253 | 6456 | 949 |
| SH2B1 | -8374 | -5465 | 219 |
| SOCS3 | 9315 | 10630 | -8810 |
| STAT3 | 7972 | 9583 | 2630 |
| STAT5A | 6864 | 7733 | -5435 |
| STAT5B | 6825 | 8618 | -5382 |
rRNA processing
| metric | value |
|---|---|
| setSize | 217 |
| pMANOVA | 8.4e-73 |
| p.adjustMANOVA | 1.04e-70 |
| s.dist | 0.766 |
| s.t0_v_pod | -0.289 |
| s.pod_crp | -0.589 |
| s.t0_crp | -0.394 |
| p.t0_v_pod | 2.16e-13 |
| p.pod_crp | 7.88e-51 |
| p.t0_crp | 1.25e-23 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| FBL | -9913 | -8826 |
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| WDR46 | -9028 | -8694 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BMS1 | -11315 | -9598 | -1337 |
| BOP1 | -5039 | -6568 | -8304 |
| BYSL | -4316 | -4876 | -6332 |
| C1D | 3484 | -321 | 11355 |
| CSNK1D | 2374 | 8356 | -7947 |
| CSNK1E | -9964 | -6501 | -4870 |
| DCAF13 | -5386 | -7538 | -2062 |
| DDX21 | 3087 | -1187 | 8531 |
| DDX47 | -10949 | -9306 | 8082 |
| DDX49 | 4816 | 4046 | -8272 |
| DDX52 | 448 | 1780 | 12323 |
| DHX37 | -7983 | -4720 | -3600 |
| DIMT1 | -7711 | -9624 | 8995 |
| DIS3 | -4187 | -4119 | 11534 |
| DKC1 | -11282 | -10110 | -3751 |
| EBNA1BP2 | -3970 | -7889 | -588 |
| ELAC2 | -11406 | -5361 | -4879 |
| EMG1 | -9856 | -8716 | 8730 |
| ERI1 | 5474 | 6607 | 11232 |
| EXOSC1 | -979 | -487 | 5176 |
| EXOSC10 | -11028 | -6804 | 6476 |
| EXOSC2 | -10724 | -9725 | -4656 |
| EXOSC3 | 503 | -40 | 4327 |
| EXOSC4 | 7485 | 9870 | -6235 |
| EXOSC5 | -4428 | -8367 | -7087 |
| EXOSC6 | -9514 | -7432 | -3150 |
| EXOSC7 | -10290 | -8445 | -8729 |
| EXOSC8 | -11104 | -9351 | 7169 |
| EXOSC9 | -9917 | -8765 | 10776 |
| FAU | -359 | -3599 | -8841 |
| FBL | -9855 | -9913 | -8826 |
| FCF1 | 4428 | 450 | 6199 |
| FTSJ3 | -3900 | -1188 | -3676 |
| GAR1 | -6703 | -7382 | 238 |
| GNL3 | -8199 | -9931 | 4303 |
| HEATR1 | -10009 | -7253 | 5481 |
| HSD17B10 | 4141 | 2954 | -6913 |
| IMP3 | -9143 | -6887 | -5060 |
| IMP4 | -10629 | -7130 | -5576 |
| ISG20L2 | 3737 | 3123 | 6401 |
| KRR1 | -8329 | -7693 | 8202 |
| LAS1L | -11905 | -9651 | -4481 |
| LTV1 | -4162 | -7094 | 5542 |
| MPHOSPH10 | -7519 | -8812 | 11917 |
| MPHOSPH6 | 2168 | -3175 | 1284 |
| MRM1 | -10179 | -8498 | -2345 |
| MRM2 | 1450 | -5146 | -2492 |
| MRM3 | -7261 | -5685 | -2876 |
| MT-ATP6 | -2053 | -2188 | -8001 |
| MT-ATP8 | -2987 | 187 | -8982 |
| MT-CO1 | 678 | -448 | -1768 |
| MT-CO2 | 48 | -2508 | -6448 |
| MT-CO3 | 40 | -5134 | -7824 |
| MT-CYB | -2209 | -2018 | -4143 |
| MT-ND1 | -3510 | -5053 | -5687 |
| MT-ND2 | -6337 | -6070 | -4921 |
| MT-ND3 | -3542 | -5498 | -7149 |
| MT-ND4 | 833 | 4453 | 5892 |
| MT-ND4L | -1983 | 2305 | -6967 |
| MT-ND5 | -2122 | -922 | -3737 |
| MT-RNR1 | -298 | -5072 | -2647 |
| MT-RNR2 | 2099 | -403 | -1533 |
| MT-TF | -2683 | 2741 | -4160 |
| MT-TL1 | -2901 | 4476 | -2094 |
| MT-TV | -3544 | 3333 | -5432 |
| MTERF4 | -10547 | -9888 | -3942 |
| MTREX | -2574 | -4473 | 5717 |
| NAT10 | -11593 | -9800 | -2380 |
| NCL | -8953 | -9308 | -4346 |
| NHP2 | -3373 | -6510 | -7363 |
| NIP7 | -5682 | -7752 | 4552 |
| NOB1 | -9986 | -8880 | -5059 |
| NOC4L | -5298 | 1593 | 234 |
| NOL11 | -10134 | -9903 | 8964 |
| NOL12 | 4887 | 4239 | -4051 |
| NOL6 | -10564 | -7807 | -3599 |
| NOL9 | -9891 | -8758 | 9241 |
| NOP10 | 8200 | 10199 | -7289 |
| NOP14 | -10522 | -9613 | -4168 |
| NOP2 | -9624 | -8280 | -6603 |
| NOP56 | -11395 | -9416 | 246 |
| NOP58 | -9623 | -10002 | 8617 |
| NSUN4 | -4645 | 2320 | 8079 |
| PDCD11 | -11166 | -6522 | -2344 |
| PELP1 | -10584 | -8205 | -1289 |
| PES1 | -1993 | -7123 | -8715 |
| PNO1 | -6627 | -7977 | 9345 |
| PRORP | 3361 | -1707 | 4824 |
| PWP2 | -1190 | -5399 | -7041 |
| RBM28 | -11316 | -5688 | 1861 |
| RCL1 | -751 | -7663 | -1012 |
| RIOK1 | -3702 | -4836 | 2397 |
| RIOK2 | 927 | -8052 | 9706 |
| RIOK3 | 8621 | 7003 | 9886 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPP14 | 2981 | -2190 | 7808 |
| RPP21 | -5178 | -4239 | -7477 |
| RPP25 | -7963 | -8660 | -2890 |
| RPP30 | -7818 | -8612 | 8067 |
| RPP38 | -6833 | -7656 | 6479 |
| RPP40 | -4680 | -10040 | 3381 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| RRP1 | -3003 | -3032 | 2020 |
| RRP36 | -1645 | -390 | -5014 |
| RRP7A | -2734 | -5222 | -4553 |
| RRP9 | -9748 | -8570 | -7939 |
| SENP3 | 2970 | 77 | -3111 |
| SNORD3A | -2477 | 10412 | 10967 |
| SNU13 | -6637 | -8467 | -6973 |
| TBL3 | -3341 | 732 | -6317 |
| TEX10 | -9440 | -8887 | 11517 |
| TFB1M | -10994 | -6834 | 7318 |
| THUMPD1 | -9477 | -9754 | 7788 |
| TRMT10C | -4336 | -8279 | 8670 |
| TRMT112 | 732 | -2281 | -8647 |
| TSR1 | -9409 | -9696 | 4264 |
| TSR3 | 3808 | 1485 | -8865 |
| UBA52 | 1112 | -3471 | -8207 |
| UTP11 | 4582 | -37 | 6683 |
| UTP14A | -1788 | -3304 | 3687 |
| UTP14C | -2032 | -2400 | 5261 |
| UTP15 | -10264 | -9128 | 11648 |
| UTP18 | 5055 | 3815 | 4880 |
| UTP20 | -10191 | -7402 | 9700 |
| UTP3 | -2829 | -4799 | -4079 |
| UTP4 | -11142 | -9672 | 3675 |
| UTP6 | -4362 | -8588 | 8987 |
| WDR12 | 5156 | -723 | 7083 |
| WDR18 | -2260 | -3796 | -3450 |
| WDR3 | -6394 | -6991 | 570 |
| WDR36 | -3825 | -5050 | 5877 |
| WDR43 | -7419 | -9367 | 167 |
| WDR46 | -10623 | -9028 | -8694 |
| WDR75 | -9593 | -9795 | 7835 |
| XRN2 | 9240 | 10090 | -4182 |
DNA strand elongation
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 6.4e-07 |
| p.adjustMANOVA | 5.09e-06 |
| s.dist | 0.762 |
| s.t0_v_pod | -0.522 |
| s.pod_crp | -0.555 |
| s.t0_crp | 0.027 |
| p.t0_v_pod | 3.22e-07 |
| p.pod_crp | 5.52e-08 |
| p.t0_crp | 0.791 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| MCM3 | -9914 | -11839 |
| POLA1 | -9813 | -11789 |
| RPA1 | -9771 | -11644 |
| MCM7 | -9297 | -11768 |
| LIG1 | -9441 | -10705 |
| POLD2 | -10025 | -10015 |
| RFC3 | -9377 | -10151 |
| RFC4 | -8869 | -10361 |
| PRIM1 | -9138 | -9858 |
| POLA2 | -7923 | -11222 |
| RFC5 | -7548 | -11357 |
| GINS4 | -8248 | -9903 |
| MCM6 | -8603 | -9393 |
| RPA3 | -9192 | -8609 |
| FEN1 | -6460 | -10254 |
| MCM8 | -5689 | -10599 |
| MCM4 | -7061 | -8404 |
| MCM2 | -6855 | -6973 |
| PCNA | -7076 | -5771 |
| GINS3 | -3854 | -10170 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CDC45 | -2594 | -5110 | 1889 |
| DNA2 | -2786 | -6282 | 10381 |
| FEN1 | -10254 | -6460 | -2374 |
| GINS1 | -4261 | 4225 | 7950 |
| GINS2 | -4661 | -3457 | 4094 |
| GINS3 | -10170 | -3854 | 5122 |
| GINS4 | -9903 | -8248 | 3992 |
| LIG1 | -10705 | -9441 | -1548 |
| MCM2 | -6973 | -6855 | -3428 |
| MCM3 | -11839 | -9914 | -2392 |
| MCM4 | -8404 | -7061 | 3202 |
| MCM5 | -7039 | -2312 | -5776 |
| MCM6 | -9393 | -8603 | 109 |
| MCM7 | -11768 | -9297 | -1374 |
| MCM8 | -10599 | -5689 | 7587 |
| PCNA | -5771 | -7076 | 6465 |
| POLA1 | -11789 | -9813 | 1029 |
| POLA2 | -11222 | -7923 | 8950 |
| POLD1 | 202 | -2557 | -6206 |
| POLD2 | -10015 | -10025 | -5321 |
| POLD3 | 8737 | 10508 | 2974 |
| POLD4 | 6250 | 8949 | -6951 |
| PRIM1 | -9858 | -9138 | 10019 |
| PRIM2 | -5389 | -7087 | 2832 |
| RFC1 | -7180 | -5058 | 9646 |
| RFC2 | 4890 | 5426 | -5388 |
| RFC3 | -10151 | -9377 | 2304 |
| RFC4 | -10361 | -8869 | 7610 |
| RFC5 | -11357 | -7548 | 3954 |
| RPA1 | -11644 | -9771 | -3472 |
| RPA2 | -6094 | -4789 | 4026 |
| RPA3 | -8609 | -9192 | 2284 |
Dissolution of Fibrin Clot
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00397 |
| p.adjustMANOVA | 0.00969 |
| s.dist | 0.762 |
| s.t0_v_pod | 0.566 |
| s.pod_crp | 0.412 |
| s.t0_crp | -0.301 |
| p.t0_v_pod | 0.000687 |
| p.pod_crp | 0.0136 |
| p.t0_crp | 0.0708 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| SERPINB2 | 9277 | 10520 |
| ANXA2 | 8405 | 10514 |
| PLAUR | 8292 | 10309 |
| SERPINB8 | 9049 | 9092 |
| SERPINE2 | 6363 | 6996 |
| SERPINE1 | 7371 | 4960 |
| S100A10 | 6764 | 5278 |
| SERPINB6 | 5778 | 5230 |
| PLAU | 4847 | 3871 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ANXA2 | 8405 | 10514 | -659 |
| PLAT | -1225 | -6169 | 4704 |
| PLAU | 4847 | 3871 | -6314 |
| PLAUR | 8292 | 10309 | -3513 |
| PLG | -1938 | 216 | 9671 |
| S100A10 | 6764 | 5278 | -5383 |
| SERPINB2 | 9277 | 10520 | -51 |
| SERPINB6 | 5778 | 5230 | -8063 |
| SERPINB8 | 9049 | 9092 | -557 |
| SERPINE1 | 7371 | 4960 | -5579 |
| SERPINE2 | 6363 | 6996 | -650 |
| SERPINF2 | -6350 | -1362 | -2370 |
Mucopolysaccharidoses
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00638 |
| p.adjustMANOVA | 0.0144 |
| s.dist | 0.751 |
| s.t0_v_pod | 0.455 |
| s.pod_crp | 0.442 |
| s.t0_crp | -0.403 |
| p.t0_v_pod | 0.009 |
| p.pod_crp | 0.0112 |
| p.t0_crp | 0.0207 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| GNS | 9200 | 11194 |
| GLB1 | 8581 | 10042 |
| GUSB | 7607 | 10966 |
| ARSB | 7459 | 9871 |
| GALNS | 6998 | 8916 |
| HYAL1 | 4123 | 8255 |
| SGSH | 5835 | 2861 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ARSB | 7459 | 9871 | 1891 |
| GALNS | 6998 | 8916 | -3718 |
| GLB1 | 8581 | 10042 | -4137 |
| GNS | 9200 | 11194 | -1445 |
| GUSB | 7607 | 10966 | -6245 |
| HGSNAT | 1854 | -729 | -724 |
| HYAL1 | 4123 | 8255 | 9608 |
| IDS | -2558 | 1326 | -2416 |
| IDUA | -5636 | -6345 | -5699 |
| NAGLU | -4608 | 1701 | -7629 |
| SGSH | 5835 | 2861 | -8621 |
Spry regulation of FGF signaling
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.000398 |
| p.adjustMANOVA | 0.00135 |
| s.dist | 0.749 |
| s.t0_v_pod | 0.475 |
| s.pod_crp | 0.372 |
| s.t0_crp | -0.445 |
| p.t0_v_pod | 0.00101 |
| p.pod_crp | 0.0101 |
| p.t0_crp | 0.00208 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| MAPK3 | 8803 | -9014 |
| GRB2 | 9146 | -5185 |
| UBB | 6548 | -6697 |
| PPP2R1A | 4542 | -7934 |
| UBC | 4395 | -4003 |
| MKNK1 | 8042 | -1799 |
| CBL | 7368 | -1624 |
| MAPK1 | 7381 | -1505 |
| UBA52 | 1112 | -8207 |
| PPP2CA | 8104 | -306 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BRAF | 1298 | 4328 | 6880 |
| CBL | 7368 | 9736 | -1624 |
| GRB2 | 9146 | 10542 | -5185 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| MKNK1 | 8042 | 10147 | -1799 |
| PPP2CA | 8104 | 6731 | -306 |
| PPP2CB | 7596 | 7359 | 4715 |
| PPP2R1A | 4542 | 5140 | -7934 |
| PTPN11 | 5253 | 6456 | 949 |
| RPS27A | -6700 | -9695 | -8668 |
| SPRY2 | -4453 | 3846 | -3763 |
| SRC | -8520 | -6371 | -3347 |
| UBA52 | 1112 | -3471 | -8207 |
| UBB | 6548 | 1016 | -6697 |
| UBC | 4395 | 6071 | -4003 |
Pentose phosphate pathway
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00223 |
| p.adjustMANOVA | 0.00601 |
| s.dist | 0.748 |
| s.t0_v_pod | 0.488 |
| s.pod_crp | 0.375 |
| s.t0_crp | -0.425 |
| p.t0_v_pod | 0.00233 |
| p.pod_crp | 0.0191 |
| p.t0_crp | 0.00796 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| G6PD | 8853 | -8678 |
| PGD | 9320 | -7817 |
| TKT | 9183 | -7915 |
| PGLS | 5997 | -8746 |
| TALDO1 | 9295 | -5166 |
| PGM2 | 9185 | -3971 |
| RPIA | 1431 | -6976 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DERA | 8364 | 9203 | 5762 |
| G6PD | 8853 | 10748 | -8678 |
| PGD | 9320 | 11020 | -7817 |
| PGLS | 5997 | 5015 | -8746 |
| PGM2 | 9185 | 10200 | -3971 |
| PRPS1 | -11716 | -9746 | -3296 |
| PRPS2 | 3530 | -3107 | 9229 |
| RBKS | -3058 | 3857 | -3699 |
| RPE | 2570 | 6736 | 3479 |
| RPIA | 1431 | -5387 | -6976 |
| SHPK | -2467 | 536 | 270 |
| TALDO1 | 9295 | 10214 | -5166 |
| TKT | 9183 | 10070 | -7915 |
DNA methylation
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 2.54e-05 |
| p.adjustMANOVA | 0.000122 |
| s.dist | 0.747 |
| s.t0_v_pod | 0.517 |
| s.pod_crp | 0.325 |
| s.t0_crp | -0.431 |
| p.t0_v_pod | 6.35e-05 |
| p.pod_crp | 0.0119 |
| p.t0_crp | 0.000836 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| H2AJ | 9214.0 | -8302.0 |
| H2BC12 | 8898.0 | -7833.0 |
| H2AZ1 | 5955.0 | -8609.0 |
| H2BC5 | 7881.0 | -5603.0 |
| H2BC11 | 7791.0 | -5097.0 |
| H2BC21 | 9125.0 | -3628.0 |
| H3C15 | 6608.5 | -4548.5 |
| H2BC9 | 5332.0 | -5547.0 |
| H2AC6 | 7813.0 | -3405.0 |
| H2BC15 | 5251.0 | -2358.0 |
| DNMT3B | 4250.0 | -1957.0 |
| H2BC17 | 7178.0 | -839.0 |
| H2BC4 | 7279.0 | -558.0 |
| H3-3A | 8519.0 | -45.0 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DNMT1 | -11896.0 | -9596.0 | -4032.0 |
| DNMT3A | -2963.0 | -2031.0 | -3936.0 |
| DNMT3B | 4250.0 | 3685.0 | -1957.0 |
| H2AC20 | 4913.0 | 8767.0 | 5501.0 |
| H2AC6 | 7813.0 | 5389.0 | -3405.0 |
| H2AJ | 9214.0 | 11227.0 | -8302.0 |
| H2AZ1 | 5955.0 | 4339.0 | -8609.0 |
| H2AZ2 | -1192.0 | -5552.0 | -5889.0 |
| H2BC11 | 7791.0 | 6057.0 | -5097.0 |
| H2BC12 | 8898.0 | 9140.0 | -7833.0 |
| H2BC15 | 5251.0 | 2455.0 | -2358.0 |
| H2BC17 | 7178.0 | 6124.0 | -839.0 |
| H2BC21 | 9125.0 | 9536.0 | -3628.0 |
| H2BC4 | 7279.0 | 8798.0 | -558.0 |
| H2BC5 | 7881.0 | 6685.0 | -5603.0 |
| H2BC9 | 5332.0 | -5704.0 | -5547.0 |
| H2BU1 | -6332.0 | 296.0 | 1215.0 |
| H3-3A | 8519.0 | 8858.0 | -45.0 |
| H3C15 | 6608.5 | 8802.5 | -4548.5 |
| UHRF1 | 168.0 | 3272.0 | 6414.0 |
COPI-independent Golgi-to-ER retrograde traffic
| metric | value |
|---|---|
| setSize | 33 |
| pMANOVA | 4.56e-07 |
| p.adjustMANOVA | 3.83e-06 |
| s.dist | 0.745 |
| s.t0_v_pod | 0.563 |
| s.pod_crp | 0.464 |
| s.t0_crp | -0.151 |
| p.t0_v_pod | 2.13e-08 |
| p.pod_crp | 3.98e-06 |
| p.t0_crp | 0.132 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| GALNT2 | 8697 | 10689 |
| DCTN2 | 9002 | 10231 |
| PLA2G4A | 9025 | 9642 |
| DCTN4 | 8255 | 10493 |
| BICD2 | 8602 | 9551 |
| RAB6A | 8020 | 9791 |
| CAPZA1 | 8008 | 9383 |
| CAPZB | 7893 | 9424 |
| ACTR1A | 6899 | 10132 |
| CAPZA2 | 8457 | 8110 |
| DYNC1LI1 | 6841 | 8160 |
| DCTN6 | 7193 | 7445 |
| RAB18 | 7683 | 6954 |
| DYNC1I2 | 7619 | 6633 |
| DCTN1 | 5019 | 9411 |
| ACTR10 | 7490 | 5826 |
| PAFAH1B1 | 5405 | 7756 |
| GALNT1 | 6420 | 6427 |
| PAFAH1B2 | 6842 | 5935 |
| DCTN3 | 5913 | 6554 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ACTR10 | 7490 | 5826 | 4427 |
| ACTR1A | 6899 | 10132 | -6961 |
| AGPAT3 | 4753 | 7831 | 3495 |
| BICD1 | -7111 | -2288 | 4117 |
| BICD2 | 8602 | 9551 | -8611 |
| CAPZA1 | 8008 | 9383 | 6293 |
| CAPZA2 | 8457 | 8110 | 4868 |
| CAPZB | 7893 | 9424 | -5476 |
| DCTN1 | 5019 | 9411 | -7351 |
| DCTN2 | 9002 | 10231 | -8920 |
| DCTN3 | 5913 | 6554 | -7228 |
| DCTN4 | 8255 | 10493 | 6145 |
| DCTN5 | -3959 | 295 | -1163 |
| DCTN6 | 7193 | 7445 | 8123 |
| DYNC1H1 | -7417 | 1692 | -1406 |
| DYNC1I1 | 4145 | 2854 | 3166 |
| DYNC1I2 | 7619 | 6633 | -395 |
| DYNC1LI1 | 6841 | 8160 | 7235 |
| DYNC1LI2 | 4229 | 7547 | 2299 |
| DYNLL1 | 5873 | 1517 | -3390 |
| DYNLL2 | -3859 | -4882 | -5771 |
| GALNT1 | 6420 | 6427 | 3010 |
| GALNT2 | 8697 | 10689 | -8116 |
| PAFAH1B1 | 5405 | 7756 | -1518 |
| PAFAH1B2 | 6842 | 5935 | 2533 |
| PAFAH1B3 | 4373 | -4023 | -8571 |
| PLA2G4A | 9025 | 9642 | -1028 |
| PLA2G6 | -11761 | -7143 | -5121 |
| RAB18 | 7683 | 6954 | 7861 |
| RAB3GAP1 | 5695 | 5118 | 10806 |
| RAB3GAP2 | 4385 | 6528 | 10304 |
| RAB6A | 8020 | 9791 | 6218 |
| RAB6B | 5972 | -1836 | -8619 |
Formation of ATP by chemiosmotic coupling
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 3.36e-07 |
| p.adjustMANOVA | 2.93e-06 |
| s.dist | 0.743 |
| s.t0_v_pod | 0.427 |
| s.pod_crp | 0.0375 |
| s.t0_crp | -0.607 |
| p.t0_v_pod | 0.00171 |
| p.pod_crp | 0.783 |
| p.t0_crp | 8.2e-06 |
| Gene | t0_crp | t0_v_pod |
|---|---|---|
| ATP5MF | -8734 | 6431 |
| ATP5MG | -8801 | 5447 |
| ATP5F1A | -6958 | 6353 |
| ATP5F1E | -7071 | 6058 |
| ATP5PB | -5394 | 7438 |
| ATP5MC3 | -6713 | 5829 |
| ATP5F1B | -4476 | 6409 |
| ATP5PF | -4251 | 6286 |
| ATP5F1D | -8739 | 2944 |
| ATP5MC2 | -8407 | 2932 |
| ATP5ME | -8860 | 2644 |
| ATP5PO | -2631 | 4739 |
| ATP5PD | -1250 | 7521 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATP5F1A | 6353 | -2835 | -6958 |
| ATP5F1B | 6409 | 5998 | -4476 |
| ATP5F1C | 6596 | 1241 | 2451 |
| ATP5F1D | 2944 | -986 | -8739 |
| ATP5F1E | 6058 | 2254 | -7071 |
| ATP5MC1 | -7353 | -6919 | -1264 |
| ATP5MC2 | 2932 | 1574 | -8407 |
| ATP5MC3 | 5829 | 3275 | -6713 |
| ATP5ME | 2644 | 3572 | -8860 |
| ATP5MF | 6431 | 6294 | -8734 |
| ATP5MG | 5447 | 547 | -8801 |
| ATP5PB | 7438 | 3444 | -5394 |
| ATP5PD | 7521 | 5119 | -1250 |
| ATP5PF | 6286 | 3290 | -4251 |
| ATP5PO | 4739 | -2304 | -2631 |
| DMAC2L | -7023 | -4321 | 11151 |
| MT-ATP6 | -2053 | -2188 | -8001 |
| MT-ATP8 | -2987 | 187 | -8982 |
Diseases associated with the TLR signaling cascade
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 7.96e-05 |
| p.adjustMANOVA | 0.000335 |
| s.dist | 0.739 |
| s.t0_v_pod | 0.534 |
| s.pod_crp | 0.48 |
| s.t0_crp | -0.177 |
| p.t0_v_pod | 9.12e-06 |
| p.pod_crp | 6.8e-05 |
| p.t0_crp | 0.143 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CD36 | 9283 | 10747 |
| TLR5 | 9045 | 10981 |
| TLR2 | 8950 | 10352 |
| MYD88 | 8009 | 11117 |
| TLR1 | 8782 | 9888 |
| CD14 | 8944 | 9321 |
| TLR4 | 8864 | 9402 |
| LY96 | 8649 | 9181 |
| TLR6 | 8694 | 8940 |
| BTK | 7100 | 10653 |
| CHUK | 7844 | 8599 |
| TICAM1 | 6221 | 8752 |
| IKBKG | 5315 | 9298 |
| TIRAP | 5571 | 8733 |
| UNC93B1 | 4129 | 10343 |
| NFKBIA | 6712 | 5405 |
| NFKB1 | 6191 | 2835 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BTK | 7100 | 10653 | 7751 |
| CD14 | 8944 | 9321 | -7666 |
| CD36 | 9283 | 10747 | -147 |
| CHUK | 7844 | 8599 | 3409 |
| IKBKB | -5208 | 1744 | -158 |
| IKBKG | 5315 | 9298 | -5591 |
| LY96 | 8649 | 9181 | 4818 |
| MYD88 | 8009 | 11117 | 3555 |
| NFKB1 | 6191 | 2835 | -2693 |
| NFKB2 | -1150 | -3508 | -3084 |
| NFKBIA | 6712 | 5405 | -8067 |
| RELA | -1770 | -201 | -7116 |
| TICAM1 | 6221 | 8752 | 3413 |
| TIRAP | 5571 | 8733 | -2324 |
| TLR1 | 8782 | 9888 | 5302 |
| TLR10 | -2886 | -7042 | -560 |
| TLR2 | 8950 | 10352 | 3541 |
| TLR3 | -11172 | -7386 | 6867 |
| TLR4 | 8864 | 9402 | -2478 |
| TLR5 | 9045 | 10981 | 2232 |
| TLR6 | 8694 | 8940 | -2193 |
| TRAF3 | -5390 | -7513 | -6014 |
| UNC93B1 | 4129 | 10343 | 1911 |
Diseases of Immune System
| metric | value |
|---|---|
| setSize | 23 |
| pMANOVA | 7.96e-05 |
| p.adjustMANOVA | 0.000335 |
| s.dist | 0.739 |
| s.t0_v_pod | 0.534 |
| s.pod_crp | 0.48 |
| s.t0_crp | -0.177 |
| p.t0_v_pod | 9.12e-06 |
| p.pod_crp | 6.8e-05 |
| p.t0_crp | 0.143 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| CD36 | 9283 | 10747 |
| TLR5 | 9045 | 10981 |
| TLR2 | 8950 | 10352 |
| MYD88 | 8009 | 11117 |
| TLR1 | 8782 | 9888 |
| CD14 | 8944 | 9321 |
| TLR4 | 8864 | 9402 |
| LY96 | 8649 | 9181 |
| TLR6 | 8694 | 8940 |
| BTK | 7100 | 10653 |
| CHUK | 7844 | 8599 |
| TICAM1 | 6221 | 8752 |
| IKBKG | 5315 | 9298 |
| TIRAP | 5571 | 8733 |
| UNC93B1 | 4129 | 10343 |
| NFKBIA | 6712 | 5405 |
| NFKB1 | 6191 | 2835 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BTK | 7100 | 10653 | 7751 |
| CD14 | 8944 | 9321 | -7666 |
| CD36 | 9283 | 10747 | -147 |
| CHUK | 7844 | 8599 | 3409 |
| IKBKB | -5208 | 1744 | -158 |
| IKBKG | 5315 | 9298 | -5591 |
| LY96 | 8649 | 9181 | 4818 |
| MYD88 | 8009 | 11117 | 3555 |
| NFKB1 | 6191 | 2835 | -2693 |
| NFKB2 | -1150 | -3508 | -3084 |
| NFKBIA | 6712 | 5405 | -8067 |
| RELA | -1770 | -201 | -7116 |
| TICAM1 | 6221 | 8752 | 3413 |
| TIRAP | 5571 | 8733 | -2324 |
| TLR1 | 8782 | 9888 | 5302 |
| TLR10 | -2886 | -7042 | -560 |
| TLR2 | 8950 | 10352 | 3541 |
| TLR3 | -11172 | -7386 | 6867 |
| TLR4 | 8864 | 9402 | -2478 |
| TLR5 | 9045 | 10981 | 2232 |
| TLR6 | 8694 | 8940 | -2193 |
| TRAF3 | -5390 | -7513 | -6014 |
| UNC93B1 | 4129 | 10343 | 1911 |
Pre-NOTCH Processing in Golgi
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 0.00012 |
| p.adjustMANOVA | 0.00048 |
| s.dist | 0.735 |
| s.t0_v_pod | 0.411 |
| s.pod_crp | 0.487 |
| s.t0_crp | -0.367 |
| p.t0_v_pod | 0.00257 |
| p.pod_crp | 0.000349 |
| p.t0_crp | 0.00701 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| FURIN | 10706 | 8922 |
| NOTCH3 | 11203 | 7778 |
| ATP2A2 | 10179 | 7915 |
| RAB6A | 9791 | 8020 |
| ST3GAL4 | 10043 | 5708 |
| SEL1L | 7782 | 6751 |
| NOTCH1 | 9352 | 4653 |
| NOTCH2 | 8283 | 5211 |
| B4GALT1 | 7664 | 4248 |
| TMED2 | 5294 | 5971 |
| RFNG | 4058 | 7126 |
| ST3GAL6 | 3195 | 6610 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATP2A1 | -4516 | 3945 | 5730 |
| ATP2A2 | 7915 | 10179 | -2373 |
| ATP2A3 | -905 | 3617 | -3734 |
| B4GALT1 | 4248 | 7664 | -6063 |
| FURIN | 8922 | 10706 | -8995 |
| LFNG | -8085 | 1201 | -3665 |
| MFNG | -5809 | -7578 | -8998 |
| NOTCH1 | 4653 | 9352 | -5530 |
| NOTCH2 | 5211 | 8283 | -3841 |
| NOTCH3 | 7778 | 11203 | -5298 |
| NOTCH4 | -5056 | 10115 | 2220 |
| RAB6A | 8020 | 9791 | 6218 |
| RFNG | 7126 | 4058 | -7848 |
| SEL1L | 6751 | 7782 | 958 |
| ST3GAL3 | 499 | -5226 | -3252 |
| ST3GAL4 | 5708 | 10043 | -7303 |
| ST3GAL6 | 6610 | 3195 | 4614 |
| TMED2 | 5971 | 5294 | 6374 |
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.0154 |
| p.adjustMANOVA | 0.0305 |
| s.dist | 0.732 |
| s.t0_v_pod | 0.476 |
| s.pod_crp | 0.549 |
| s.t0_crp | -0.088 |
| p.t0_v_pod | 0.00629 |
| p.pod_crp | 0.00161 |
| p.t0_crp | 0.613 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| LYN | 10614 | 7691 |
| PIK3CB | 8995 | 8886 |
| IRS2 | 9284 | 8429 |
| EPOR | 10228 | 7117 |
| PIK3CD | 8829 | 5965 |
| GAB1 | 8548 | 5607 |
| PIK3CG | 8997 | 1820 |
| JAK2 | 4389 | 2670 |
| PIK3CA | 2117 | 4580 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| EPOR | 7117 | 10228 | -4401 |
| GAB1 | 5607 | 8548 | 9775 |
| IRS2 | 8429 | 9284 | -8471 |
| JAK2 | 2670 | 4389 | 12253 |
| LYN | 7691 | 10614 | 7111 |
| PIK3CA | 4580 | 2117 | 7009 |
| PIK3CB | 8886 | 8995 | 800 |
| PIK3CD | 5965 | 8829 | -6091 |
| PIK3CG | 1820 | 8997 | 1774 |
| PIK3R1 | -9187 | -8803 | -5081 |
| PIK3R5 | -2255 | 7483 | -6821 |
Golgi Cisternae Pericentriolar Stack Reorganization
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00397 |
| p.adjustMANOVA | 0.00969 |
| s.dist | 0.731 |
| s.t0_v_pod | 0.549 |
| s.pod_crp | 0.481 |
| s.t0_crp | 0.0291 |
| p.t0_v_pod | 0.000374 |
| p.pod_crp | 0.00183 |
| p.t0_crp | 0.851 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| RAB1A | 8899 | 9804 |
| MAPK3 | 8803 | 9593 |
| MAPK1 | 7381 | 10983 |
| RAB1B | 8182 | 9884 |
| RAB2A | 8464 | 9430 |
| GORASP1 | 6516 | 9480 |
| GOLGA2 | 6117 | 9269 |
| CCNB2 | 3649 | 7198 |
| PLK1 | 2978 | 5349 |
| BLZF1 | 3253 | 3702 |
| USO1 | 4113 | 2405 |
| CCNB1 | 461 | 728 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BLZF1 | 3253 | 3702 | 12053 |
| CCNB1 | 461 | 728 | 6815 |
| CCNB2 | 3649 | 7198 | 3957 |
| CDK1 | 1527 | -2576 | 8213 |
| GOLGA2 | 6117 | 9269 | -3697 |
| GORASP1 | 6516 | 9480 | -1306 |
| GORASP2 | -6792 | -5521 | 897 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| PLK1 | 2978 | 5349 | 1784 |
| RAB1A | 8899 | 9804 | 1916 |
| RAB1B | 8182 | 9884 | -8628 |
| RAB2A | 8464 | 9430 | 6039 |
| USO1 | 4113 | 2405 | 9996 |
Phosphorylation of CD3 and TCR zeta chains
| metric | value |
|---|---|
| setSize | 27 |
| pMANOVA | 1.07e-05 |
| p.adjustMANOVA | 5.8e-05 |
| s.dist | 0.728 |
| s.t0_v_pod | -0.537 |
| s.pod_crp | -0.486 |
| s.t0_crp | -0.0775 |
| p.t0_v_pod | 1.39e-06 |
| p.pod_crp | 1.22e-05 |
| p.t0_crp | 0.486 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| LCK | -11482 | -9528 |
| TRBC1 | -11646 | -9275 |
| TRAC | -11130 | -9675 |
| HLA-DRA | -11649 | -8978 |
| CD247 | -11982 | -8713 |
| CD3E | -10952 | -9221 |
| TRBV12-3 | -10099 | -9942 |
| HLA-DPB1 | -11887 | -8370 |
| HLA-DPA1 | -11954 | -8190 |
| CD3D | -11049 | -8270 |
| CD3G | -11173 | -8084 |
| TRAV19 | -9587 | -9220 |
| HLA-DQB2 | -9085 | -9628 |
| TRAV29DV5 | -9353 | -9250 |
| TRBV7-9 | -9220 | -8276 |
| HLA-DQA1 | -11633 | -6364 |
| HLA-DQA2 | -4652 | -8746 |
| CD4 | -5228 | -6856 |
| TRAV8-4 | -7010 | -4747 |
| HLA-DQB1 | -6199 | -4437 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CD247 | -11982 | -8713 | -6364 |
| CD3D | -11049 | -8270 | 2178 |
| CD3E | -10952 | -9221 | 5038 |
| CD3G | -11173 | -8084 | 8697 |
| CD4 | -5228 | -6856 | -6272 |
| CSK | 5158 | 9258 | -7001 |
| HLA-DPA1 | -11954 | -8190 | 4347 |
| HLA-DPB1 | -11887 | -8370 | -2273 |
| HLA-DQA1 | -11633 | -6364 | 10152 |
| HLA-DQA2 | -4652 | -8746 | -8618 |
| HLA-DQB1 | -6199 | -4437 | 3070 |
| HLA-DQB2 | -9085 | -9628 | -6796 |
| HLA-DRA | -11649 | -8978 | 726 |
| HLA-DRB1 | -7792 | -330 | 8671 |
| HLA-DRB5 | -4806 | 741 | 5896 |
| LCK | -11482 | -9528 | -3384 |
| PAG1 | 5207 | 5991 | 810 |
| PTPN22 | -1191 | 6886 | 8220 |
| PTPRC | 2227 | 7917 | 8607 |
| PTPRJ | 7666 | 10161 | -5457 |
| TRAC | -11130 | -9675 | 7034 |
| TRAV19 | -9587 | -9220 | -3070 |
| TRAV29DV5 | -9353 | -9250 | -1621 |
| TRAV8-4 | -7010 | -4747 | 11211 |
| TRBC1 | -11646 | -9275 | 1902 |
| TRBV12-3 | -10099 | -9942 | -8483 |
| TRBV7-9 | -9220 | -8276 | -4880 |
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000146 |
| p.adjustMANOVA | 0.000566 |
| s.dist | 0.725 |
| s.t0_v_pod | 0.513 |
| s.pod_crp | 0.383 |
| s.t0_crp | -0.342 |
| p.t0_v_pod | 7.17e-05 |
| p.pod_crp | 0.00306 |
| p.t0_crp | 0.00808 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| LMNB1 | 9186 | 10717 |
| CDK5 | 8475 | 10442 |
| CAPN1 | 8424 | 10386 |
| FOXO3 | 8540 | 9639 |
| YWHAE | 8892 | 8844 |
| CAPNS1 | 7613 | 10022 |
| BCL2L11 | 7274 | 9012 |
| GOLGA2 | 6117 | 9269 |
| APP | 9022 | 6180 |
| CAST | 8036 | 6183 |
| SOD2 | 4346 | 7197 |
| PRDX1 | 6927 | 3767 |
| JUN | 3688 | 3095 |
| LMNA | 3849 | 2060 |
| CAPN2 | 1055 | 5319 |
| CDC25A | 2888 | 315 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| APP | 9022 | 6180 | -6109 |
| BCL2L11 | 7274 | 9012 | -799 |
| CAPN1 | 8424 | 10386 | -7700 |
| CAPN2 | 1055 | 5319 | 5265 |
| CAPNS1 | 7613 | 10022 | -4453 |
| CAST | 8036 | 6183 | -3098 |
| CDC25A | 2888 | 315 | -3716 |
| CDC25B | -11657 | -9722 | 2652 |
| CDK5 | 8475 | 10442 | -708 |
| CDK5R1 | -1075 | 1351 | -6946 |
| FASLG | -12008 | -7205 | -3008 |
| FOXO3 | 8540 | 9639 | -6589 |
| GOLGA2 | 6117 | 9269 | -3697 |
| JUN | 3688 | 3095 | -5986 |
| LMNA | 3849 | 2060 | -5944 |
| LMNB1 | 9186 | 10717 | 8859 |
| PRDX1 | 6927 | 3767 | 3340 |
| PRDX2 | 3398 | -4018 | -5960 |
| SOD2 | 4346 | 7197 | 3619 |
| YWHAE | 8892 | 8844 | 1002 |
Neurodegenerative Diseases
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000146 |
| p.adjustMANOVA | 0.000566 |
| s.dist | 0.725 |
| s.t0_v_pod | 0.513 |
| s.pod_crp | 0.383 |
| s.t0_crp | -0.342 |
| p.t0_v_pod | 7.17e-05 |
| p.pod_crp | 0.00306 |
| p.t0_crp | 0.00808 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| LMNB1 | 9186 | 10717 |
| CDK5 | 8475 | 10442 |
| CAPN1 | 8424 | 10386 |
| FOXO3 | 8540 | 9639 |
| YWHAE | 8892 | 8844 |
| CAPNS1 | 7613 | 10022 |
| BCL2L11 | 7274 | 9012 |
| GOLGA2 | 6117 | 9269 |
| APP | 9022 | 6180 |
| CAST | 8036 | 6183 |
| SOD2 | 4346 | 7197 |
| PRDX1 | 6927 | 3767 |
| JUN | 3688 | 3095 |
| LMNA | 3849 | 2060 |
| CAPN2 | 1055 | 5319 |
| CDC25A | 2888 | 315 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| APP | 9022 | 6180 | -6109 |
| BCL2L11 | 7274 | 9012 | -799 |
| CAPN1 | 8424 | 10386 | -7700 |
| CAPN2 | 1055 | 5319 | 5265 |
| CAPNS1 | 7613 | 10022 | -4453 |
| CAST | 8036 | 6183 | -3098 |
| CDC25A | 2888 | 315 | -3716 |
| CDC25B | -11657 | -9722 | 2652 |
| CDK5 | 8475 | 10442 | -708 |
| CDK5R1 | -1075 | 1351 | -6946 |
| FASLG | -12008 | -7205 | -3008 |
| FOXO3 | 8540 | 9639 | -6589 |
| GOLGA2 | 6117 | 9269 | -3697 |
| JUN | 3688 | 3095 | -5986 |
| LMNA | 3849 | 2060 | -5944 |
| LMNB1 | 9186 | 10717 | 8859 |
| PRDX1 | 6927 | 3767 | 3340 |
| PRDX2 | 3398 | -4018 | -5960 |
| SOD2 | 4346 | 7197 | 3619 |
| YWHAE | 8892 | 8844 | 1002 |
rRNA modification in the nucleus and cytosol
| metric | value |
|---|---|
| setSize | 59 |
| pMANOVA | 8.26e-14 |
| p.adjustMANOVA | 1.54e-12 |
| s.dist | 0.722 |
| s.t0_v_pod | -0.397 |
| s.pod_crp | -0.584 |
| s.t0_crp | -0.152 |
| p.t0_v_pod | 1.32e-07 |
| p.pod_crp | 8.38e-15 |
| p.t0_crp | 0.0435 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| DKC1 | -10110 | -11282 |
| NAT10 | -9800 | -11593 |
| BMS1 | -9598 | -11315 |
| UTP4 | -9672 | -11142 |
| NOP56 | -9416 | -11395 |
| DDX47 | -9306 | -10949 |
| NOP14 | -9613 | -10522 |
| NOL11 | -9903 | -10134 |
| FBL | -9913 | -9855 |
| NOP58 | -10002 | -9623 |
| WDR46 | -9028 | -10623 |
| WDR75 | -9795 | -9593 |
| UTP15 | -9128 | -10264 |
| THUMPD1 | -9754 | -9477 |
| EMG1 | -8716 | -9856 |
| RRP9 | -8570 | -9748 |
| NOL6 | -7807 | -10564 |
| NOP2 | -8280 | -9624 |
| IMP4 | -7130 | -10629 |
| UTP20 | -7402 | -10191 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BMS1 | -11315 | -9598 | -1337 |
| DCAF13 | -5386 | -7538 | -2062 |
| DDX47 | -10949 | -9306 | 8082 |
| DDX49 | 4816 | 4046 | -8272 |
| DDX52 | 448 | 1780 | 12323 |
| DHX37 | -7983 | -4720 | -3600 |
| DIMT1 | -7711 | -9624 | 8995 |
| DKC1 | -11282 | -10110 | -3751 |
| EMG1 | -9856 | -8716 | 8730 |
| FBL | -9855 | -9913 | -8826 |
| FCF1 | 4428 | 450 | 6199 |
| GAR1 | -6703 | -7382 | 238 |
| HEATR1 | -10009 | -7253 | 5481 |
| IMP3 | -9143 | -6887 | -5060 |
| IMP4 | -10629 | -7130 | -5576 |
| KRR1 | -8329 | -7693 | 8202 |
| MPHOSPH10 | -7519 | -8812 | 11917 |
| NAT10 | -11593 | -9800 | -2380 |
| NHP2 | -3373 | -6510 | -7363 |
| NOC4L | -5298 | 1593 | 234 |
| NOL11 | -10134 | -9903 | 8964 |
| NOL6 | -10564 | -7807 | -3599 |
| NOP10 | 8200 | 10199 | -7289 |
| NOP14 | -10522 | -9613 | -4168 |
| NOP2 | -9624 | -8280 | -6603 |
| NOP56 | -11395 | -9416 | 246 |
| NOP58 | -9623 | -10002 | 8617 |
| PDCD11 | -11166 | -6522 | -2344 |
| PNO1 | -6627 | -7977 | 9345 |
| PWP2 | -1190 | -5399 | -7041 |
| RCL1 | -751 | -7663 | -1012 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS9 | 5358 | 1826 | -8433 |
| RRP36 | -1645 | -390 | -5014 |
| RRP7A | -2734 | -5222 | -4553 |
| RRP9 | -9748 | -8570 | -7939 |
| SNORD3A | -2477 | 10412 | 10967 |
| SNU13 | -6637 | -8467 | -6973 |
| TBL3 | -3341 | 732 | -6317 |
| THUMPD1 | -9477 | -9754 | 7788 |
| TRMT112 | 732 | -2281 | -8647 |
| TSR3 | 3808 | 1485 | -8865 |
| UTP11 | 4582 | -37 | 6683 |
| UTP14A | -1788 | -3304 | 3687 |
| UTP14C | -2032 | -2400 | 5261 |
| UTP15 | -10264 | -9128 | 11648 |
| UTP18 | 5055 | 3815 | 4880 |
| UTP20 | -10191 | -7402 | 9700 |
| UTP3 | -2829 | -4799 | -4079 |
| UTP4 | -11142 | -9672 | 3675 |
| UTP6 | -4362 | -8588 | 8987 |
| WDR3 | -6394 | -6991 | 570 |
| WDR36 | -3825 | -5050 | 5877 |
| WDR43 | -7419 | -9367 | 167 |
| WDR46 | -10623 | -9028 | -8694 |
| WDR75 | -9593 | -9795 | 7835 |
EGFR downregulation
| metric | value |
|---|---|
| setSize | 27 |
| pMANOVA | 1.4e-06 |
| p.adjustMANOVA | 9.99e-06 |
| s.dist | 0.713 |
| s.t0_v_pod | 0.46 |
| s.pod_crp | 0.294 |
| s.t0_crp | -0.459 |
| p.t0_v_pod | 3.48e-05 |
| p.pod_crp | 0.00823 |
| p.t0_crp | 3.69e-05 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| EPN1 | 7922 | -7974 |
| SH3GL1 | 7509 | -8046 |
| GRB2 | 9146 | -5185 |
| AREG | 5897 | -7756 |
| EGF | 8050 | -5617 |
| TGFA | 8740 | -5172 |
| UBB | 6548 | -6697 |
| HBEGF | 4954 | -8152 |
| PTPN12 | 8023 | -4074 |
| EPS15L1 | 3621 | -5039 |
| UBC | 4395 | -4003 |
| SPRY1 | 2289 | -7416 |
| EREG | 1875 | -7212 |
| CBL | 7368 | -1624 |
| UBA52 | 1112 | -8207 |
| SH3KBP1 | 6089 | -751 |
| HGS | 4468 | -507 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AREG | 5897 | 2368 | -7756 |
| ARHGEF7 | -4434 | -471 | -6407 |
| CBL | 7368 | 9736 | -1624 |
| CDC42 | 7425 | 8226 | 5599 |
| EGF | 8050 | 5218 | -5617 |
| EPGN | 2642 | -1230 | 1721 |
| EPN1 | 7922 | 10507 | -7974 |
| EPS15 | 4097 | 5996 | 11320 |
| EPS15L1 | 3621 | 8342 | -5039 |
| EREG | 1875 | -246 | -7212 |
| GRB2 | 9146 | 10542 | -5185 |
| HBEGF | 4954 | 2048 | -8152 |
| HGS | 4468 | 9176 | -507 |
| PTPN12 | 8023 | 7625 | -4074 |
| PTPN3 | -85 | 188 | -1690 |
| PTPRK | -7011 | -9114 | -7295 |
| RPS27A | -6700 | -9695 | -8668 |
| SH3GL1 | 7509 | 9479 | -8046 |
| SH3KBP1 | 6089 | 5825 | -751 |
| SPRY1 | 2289 | -1262 | -7416 |
| SPRY2 | -4453 | 3846 | -3763 |
| STAM | 1275 | 898 | 3823 |
| STAM2 | 6075 | 7339 | 11256 |
| TGFA | 8740 | 10781 | -5172 |
| UBA52 | 1112 | -3471 | -8207 |
| UBB | 6548 | 1016 | -6697 |
| UBC | 4395 | 6071 | -4003 |
Activation of ATR in response to replication stress
| metric | value |
|---|---|
| setSize | 36 |
| pMANOVA | 2.43e-07 |
| p.adjustMANOVA | 2.15e-06 |
| s.dist | 0.713 |
| s.t0_v_pod | -0.452 |
| s.pod_crp | -0.516 |
| s.t0_crp | 0.194 |
| p.t0_v_pod | 2.73e-06 |
| p.pod_crp | 8.15e-08 |
| p.t0_crp | 0.0435 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| MCM3 | -9914 | -11839 |
| RAD1 | -9868 | -11845 |
| RPA1 | -9771 | -11644 |
| MCM7 | -9297 | -11768 |
| RFC3 | -9377 | -10151 |
| DBF4 | -8879 | -10581 |
| RFC4 | -8869 | -10361 |
| RFC5 | -7548 | -11357 |
| RAD17 | -8465 | -9973 |
| RAD9A | -7436 | -11083 |
| ORC3 | -7862 | -10371 |
| MCM6 | -8603 | -9393 |
| RPA3 | -9192 | -8609 |
| ORC2 | -8229 | -9594 |
| ORC5 | -8511 | -9161 |
| MCM8 | -5689 | -10599 |
| MCM4 | -7061 | -8404 |
| ATR | -5316 | -10018 |
| MCM2 | -6855 | -6973 |
| ATRIP | -3584 | -11134 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATR | -10018 | -5316 | 8973 |
| ATRIP | -11134 | -3584 | 6208 |
| CDC25A | 2888 | 315 | -3716 |
| CDC45 | -2594 | -5110 | 1889 |
| CDC6 | 2356 | -1584 | 3684 |
| CDC7 | -7583 | -4471 | -125 |
| CDK2 | -4840 | -3595 | 835 |
| CHEK1 | -2421 | -6118 | 4970 |
| CLSPN | 3606 | 1952 | 9332 |
| DBF4 | -10581 | -8879 | 10352 |
| HUS1 | -145 | 4198 | 8777 |
| MCM10 | 769 | -4565 | 4390 |
| MCM2 | -6973 | -6855 | -3428 |
| MCM3 | -11839 | -9914 | -2392 |
| MCM4 | -8404 | -7061 | 3202 |
| MCM5 | -7039 | -2312 | -5776 |
| MCM6 | -9393 | -8603 | 109 |
| MCM7 | -11768 | -9297 | -1374 |
| MCM8 | -10599 | -5689 | 7587 |
| ORC1 | -2459 | -2954 | 1035 |
| ORC2 | -9594 | -8229 | 7471 |
| ORC3 | -10371 | -7862 | 10286 |
| ORC4 | -1988 | -6242 | 8361 |
| ORC5 | -9161 | -8511 | 9855 |
| ORC6 | 1174 | 5286 | 4883 |
| RAD1 | -11845 | -9868 | 7325 |
| RAD17 | -9973 | -8465 | 7802 |
| RAD9A | -11083 | -7436 | 3975 |
| RAD9B | 3065 | 6526 | 8458 |
| RFC2 | 4890 | 5426 | -5388 |
| RFC3 | -10151 | -9377 | 2304 |
| RFC4 | -10361 | -8869 | 7610 |
| RFC5 | -11357 | -7548 | 3954 |
| RPA1 | -11644 | -9771 | -3472 |
| RPA2 | -6094 | -4789 | 4026 |
| RPA3 | -8609 | -9192 | 2284 |
Lagging Strand Synthesis
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000414 |
| p.adjustMANOVA | 0.0014 |
| s.dist | 0.71 |
| s.t0_v_pod | -0.452 |
| s.pod_crp | -0.546 |
| s.t0_crp | 0.038 |
| p.t0_v_pod | 0.000465 |
| p.pod_crp | 2.35e-05 |
| p.t0_crp | 0.769 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| POLA1 | -9813 | -11789 |
| RPA1 | -9771 | -11644 |
| LIG1 | -9441 | -10705 |
| POLD2 | -10025 | -10015 |
| RFC3 | -9377 | -10151 |
| RFC4 | -8869 | -10361 |
| PRIM1 | -9138 | -9858 |
| POLA2 | -7923 | -11222 |
| RFC5 | -7548 | -11357 |
| RPA3 | -9192 | -8609 |
| FEN1 | -6460 | -10254 |
| PCNA | -7076 | -5771 |
| PRIM2 | -7087 | -5389 |
| RFC1 | -5058 | -7180 |
| RPA2 | -4789 | -6094 |
| DNA2 | -6282 | -2786 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DNA2 | -2786 | -6282 | 10381 |
| FEN1 | -10254 | -6460 | -2374 |
| LIG1 | -10705 | -9441 | -1548 |
| PCNA | -5771 | -7076 | 6465 |
| POLA1 | -11789 | -9813 | 1029 |
| POLA2 | -11222 | -7923 | 8950 |
| POLD1 | 202 | -2557 | -6206 |
| POLD2 | -10015 | -10025 | -5321 |
| POLD3 | 8737 | 10508 | 2974 |
| POLD4 | 6250 | 8949 | -6951 |
| PRIM1 | -9858 | -9138 | 10019 |
| PRIM2 | -5389 | -7087 | 2832 |
| RFC1 | -7180 | -5058 | 9646 |
| RFC2 | 4890 | 5426 | -5388 |
| RFC3 | -10151 | -9377 | 2304 |
| RFC4 | -10361 | -8869 | 7610 |
| RFC5 | -11357 | -7548 | 3954 |
| RPA1 | -11644 | -9771 | -3472 |
| RPA2 | -6094 | -4789 | 4026 |
| RPA3 | -8609 | -9192 | 2284 |
Budding and maturation of HIV virion
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 1.32e-05 |
| p.adjustMANOVA | 6.96e-05 |
| s.dist | 0.708 |
| s.t0_v_pod | 0.525 |
| s.pod_crp | 0.373 |
| s.t0_crp | -0.293 |
| p.t0_v_pod | 3.5e-06 |
| p.pod_crp | 0.00098 |
| p.t0_crp | 0.00975 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| UBAP1 | 8559 | 10174 |
| CHMP4B | 8718 | 9980 |
| CHMP2A | 8635 | 10030 |
| VPS37C | 7888 | 10221 |
| CHMP3 | 8217 | 8485 |
| NEDD4L | 7755 | 8958 |
| TSG101 | 7669 | 7800 |
| PDCD6IP | 6440 | 9153 |
| VPS37A | 6379 | 8637 |
| MVB12A | 7290 | 6903 |
| CHMP5 | 4886 | 9864 |
| MVB12B | 5115 | 8610 |
| CHMP6 | 5434 | 7713 |
| VPS37B | 3869 | 8493 |
| UBC | 4395 | 6071 |
| VPS4B | 5151 | 4876 |
| VTA1 | 6101 | 3904 |
| CHMP2B | 5641 | 3060 |
| CHMP4A | 2384 | 3434 |
| UBB | 6548 | 1016 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CHMP2A | 8635 | 10030 | -7692 |
| CHMP2B | 5641 | 3060 | 6804 |
| CHMP3 | 8217 | 8485 | 705 |
| CHMP4A | 2384 | 3434 | 4816 |
| CHMP4B | 8718 | 9980 | -8710 |
| CHMP5 | 4886 | 9864 | 11784 |
| CHMP6 | 5434 | 7713 | -8792 |
| CHMP7 | -8503 | -9011 | -215 |
| MVB12A | 7290 | 6903 | -8242 |
| MVB12B | 5115 | 8610 | -695 |
| NEDD4L | 7755 | 8958 | -3521 |
| PDCD6IP | 6440 | 9153 | 8901 |
| PPIA | -6535 | -6473 | -6217 |
| RPS27A | -6700 | -9695 | -8668 |
| TSG101 | 7669 | 7800 | 4356 |
| UBA52 | 1112 | -3471 | -8207 |
| UBAP1 | 8559 | 10174 | -5375 |
| UBB | 6548 | 1016 | -6697 |
| UBC | 4395 | 6071 | -4003 |
| VPS28 | 4156 | -749 | -8515 |
| VPS37A | 6379 | 8637 | 9727 |
| VPS37B | 3869 | 8493 | -7026 |
| VPS37C | 7888 | 10221 | -935 |
| VPS4A | 777 | 167 | -8270 |
| VPS4B | 5151 | 4876 | 7128 |
| VTA1 | 6101 | 3904 | 9297 |
Processive synthesis on the lagging strand
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00333 |
| p.adjustMANOVA | 0.00831 |
| s.dist | 0.7 |
| s.t0_v_pod | -0.431 |
| s.pod_crp | -0.552 |
| s.t0_crp | -0.0108 |
| p.t0_v_pod | 0.00386 |
| p.pod_crp | 0.000214 |
| p.t0_crp | 0.942 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| POLA1 | -9813 | -11789 |
| RPA1 | -9771 | -11644 |
| LIG1 | -9441 | -10705 |
| POLD2 | -10025 | -10015 |
| PRIM1 | -9138 | -9858 |
| POLA2 | -7923 | -11222 |
| RPA3 | -9192 | -8609 |
| FEN1 | -6460 | -10254 |
| PCNA | -7076 | -5771 |
| PRIM2 | -7087 | -5389 |
| RPA2 | -4789 | -6094 |
| DNA2 | -6282 | -2786 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DNA2 | -2786 | -6282 | 10381 |
| FEN1 | -10254 | -6460 | -2374 |
| LIG1 | -10705 | -9441 | -1548 |
| PCNA | -5771 | -7076 | 6465 |
| POLA1 | -11789 | -9813 | 1029 |
| POLA2 | -11222 | -7923 | 8950 |
| POLD1 | 202 | -2557 | -6206 |
| POLD2 | -10015 | -10025 | -5321 |
| POLD3 | 8737 | 10508 | 2974 |
| POLD4 | 6250 | 8949 | -6951 |
| PRIM1 | -9858 | -9138 | 10019 |
| PRIM2 | -5389 | -7087 | 2832 |
| RPA1 | -11644 | -9771 | -3472 |
| RPA2 | -6094 | -4789 | 4026 |
| RPA3 | -8609 | -9192 | 2284 |
InlB-mediated entry of Listeria monocytogenes into host cell
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00869 |
| p.adjustMANOVA | 0.0188 |
| s.dist | 0.7 |
| s.t0_v_pod | 0.525 |
| s.pod_crp | 0.361 |
| s.t0_crp | -0.29 |
| p.t0_v_pod | 0.00164 |
| p.pod_crp | 0.0306 |
| p.t0_crp | 0.0822 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| GRB2 | 9146 | 10542 |
| CBL | 7368 | 9736 |
| SH3GL1 | 7509 | 9479 |
| STAM2 | 6075 | 7339 |
| HGS | 4468 | 9176 |
| SH3KBP1 | 6089 | 5825 |
| UBC | 4395 | 6071 |
| EPS15 | 4097 | 5996 |
| UBB | 6548 | 1016 |
| STAM | 1275 | 898 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CBL | 7368 | 9736 | -1624 |
| EPS15 | 4097 | 5996 | 11320 |
| GRB2 | 9146 | 10542 | -5185 |
| HGS | 4468 | 9176 | -507 |
| RPS27A | -6700 | -9695 | -8668 |
| SH3GL1 | 7509 | 9479 | -8046 |
| SH3KBP1 | 6089 | 5825 | -751 |
| STAM | 1275 | 898 | 3823 |
| STAM2 | 6075 | 7339 | 11256 |
| UBA52 | 1112 | -3471 | -8207 |
| UBB | 6548 | 1016 | -6697 |
| UBC | 4395 | 6071 | -4003 |
Influenza Infection
| metric | value |
|---|---|
| setSize | 154 |
| pMANOVA | 8.65e-49 |
| p.adjustMANOVA | 4.36e-47 |
| s.dist | 0.699 |
| s.t0_v_pod | -0.181 |
| s.pod_crp | -0.499 |
| s.t0_crp | -0.455 |
| p.t0_v_pod | 0.000107 |
| p.pod_crp | 1.06e-26 |
| p.t0_crp | 1.61e-22 |
| Gene | pod_crp | t0_crp |
|---|---|---|
| RPL3 | -9928 | -8773 |
| RPS2 | -9563 | -9021 |
| RPS27A | -9695 | -8668 |
| RPL14 | -9670 | -8650 |
| RPLP2 | -9135 | -9001 |
| RPS12 | -9242 | -8852 |
| RPS3 | -9270 | -8726 |
| RPLP0 | -9199 | -8702 |
| RPS27 | -9147 | -8693 |
| RPL10 | -9003 | -8829 |
| RPL7 | -9737 | -8087 |
| RPS23 | -9359 | -8319 |
| RPL27A | -9020 | -8573 |
| RPS29 | -8609 | -8958 |
| RPS6 | -9671 | -7892 |
| RPL31 | -8741 | -8685 |
| RPL30 | -8902 | -8504 |
| RPL29 | -8593 | -8787 |
| RPS5 | -9014 | -8342 |
| RPL18A | -8868 | -8439 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AAAS | -8101 | -3313 | -2106 |
| CALR | 6254 | 7615 | 3125 |
| CANX | 5462 | 3303 | 265 |
| CLTA | 8244 | 7078 | -5807 |
| CLTC | 8849 | 10126 | -1573 |
| CPSF4 | -9100 | -4004 | -6293 |
| DNAJC3 | 8302 | 9670 | 4528 |
| EIF2AK2 | -8803 | 5541 | 12317 |
| FAU | -359 | -3599 | -8841 |
| GRSF1 | 5110 | -2905 | 1530 |
| GTF2F1 | 4893 | 6665 | -7408 |
| GTF2F2 | 5371 | 6192 | 438 |
| HSP90AA1 | 1316 | -3995 | 7175 |
| HSPA1A | 7946 | 9200 | -6997 |
| IPO5 | -10252 | -10100 | -1600 |
| ISG15 | -11672 | -5052 | 11864 |
| KPNA1 | 1286 | -1299 | 6174 |
| KPNA2 | -6675 | -2520 | 5087 |
| KPNA3 | 916 | -1951 | 8594 |
| KPNA4 | 4899 | 5641 | 9435 |
| KPNA5 | -11535 | -8989 | 11307 |
| KPNB1 | 2414 | 5550 | 9459 |
| NDC1 | -11812 | -10048 | 3076 |
| NUP107 | -10085 | -8258 | 10051 |
| NUP133 | -7491 | -5322 | 4290 |
| NUP153 | -6108 | 252 | 4792 |
| NUP155 | -9900 | -7036 | 7468 |
| NUP160 | -10219 | -8330 | 7352 |
| NUP188 | -11270 | -7926 | -3035 |
| NUP205 | -10971 | -7490 | 2507 |
| NUP210 | -10384 | -3928 | -3875 |
| NUP214 | 7800 | 9957 | -379 |
| NUP35 | -10272 | -9698 | 3192 |
| NUP37 | 3049 | -2260 | 1416 |
| NUP42 | -5378 | -4024 | 11148 |
| NUP43 | -9198 | -8341 | 11362 |
| NUP50 | 4476 | 2618 | 7485 |
| NUP54 | -8189 | -7106 | 12095 |
| NUP58 | 8674 | 9426 | 5938 |
| NUP62 | 763 | -2395 | -4223 |
| NUP85 | -2971 | -3408 | 2948 |
| NUP88 | -11046 | -9640 | 5761 |
| NUP93 | -11266 | -6433 | 6407 |
| NUP98 | 3075 | 5814 | 2773 |
| PABPN1 | -522 | -1776 | -6898 |
| PARP1 | -11409 | -8364 | -1542 |
| POLR2A | -3010 | 7751 | -1889 |
| POLR2B | -2462 | -3365 | 1497 |
| POLR2C | 1603 | -488 | -4803 |
| POLR2D | -3902 | -6831 | 4997 |
| POLR2E | 7450 | 5062 | -8755 |
| POLR2F | 4555 | 4218 | -8409 |
| POLR2G | 3477 | 4138 | -8391 |
| POLR2H | -2867 | -6175 | -6959 |
| POLR2I | 394 | -3908 | -8198 |
| POLR2J | 6580 | 5544 | -7980 |
| POLR2K | -1750 | -4885 | 7558 |
| POLR2L | 5244 | 2000 | -9013 |
| POM121 | -8013 | -140 | -3047 |
| POM121C | -6940 | -1697 | -6610 |
| RAE1 | 5105 | 4962 | 4462 |
| RAN | -6558 | -8447 | 285 |
| RANBP2 | -814 | -1130 | 7725 |
| RPL10 | -6311 | -9003 | -8829 |
| RPL10A | -6458 | -8900 | -6147 |
| RPL11 | -6052 | -9089 | -6722 |
| RPL12 | -6811 | -9149 | -8024 |
| RPL13 | -3335 | -7644 | -6367 |
| RPL13A | -7928 | -9374 | -6207 |
| RPL14 | -6480 | -9670 | -8650 |
| RPL15 | -953 | -8142 | -8235 |
| RPL17 | -5249 | -9088 | -8079 |
| RPL18 | -4911 | -8835 | -8406 |
| RPL18A | -5869 | -8868 | -8439 |
| RPL19 | -6071 | -8311 | -8149 |
| RPL21 | -6241 | -9483 | -7230 |
| RPL22 | -4587 | -9631 | -7480 |
| RPL22L1 | -1593 | -8175 | 527 |
| RPL23 | -3223 | -8346 | -7486 |
| RPL23A | -9248 | -9950 | -4950 |
| RPL24 | -5606 | -8873 | -7028 |
| RPL26 | -6387 | -8678 | -8038 |
| RPL26L1 | 7070 | 5940 | -5499 |
| RPL27 | -2783 | -7783 | -8809 |
| RPL27A | -6048 | -9020 | -8573 |
| RPL28 | -1441 | -3852 | -5654 |
| RPL29 | -3505 | -8593 | -8787 |
| RPL3 | -8268 | -9928 | -8773 |
| RPL30 | -6779 | -8902 | -8504 |
| RPL31 | -4394 | -8741 | -8685 |
| RPL32 | -6479 | -9317 | -7991 |
| RPL34 | -6569 | -9464 | -6337 |
| RPL35 | -7809 | -8156 | -7893 |
| RPL35A | -5816 | -9263 | -7997 |
| RPL36 | -5111 | -7467 | -8861 |
| RPL36A | -7122 | -8881 | -8095 |
| RPL36AL | 32 | -6621 | -8799 |
| RPL37 | -6160 | -7834 | -9017 |
| RPL37A | -3826 | -6808 | -8683 |
| RPL38 | -5646 | -7941 | -8932 |
| RPL39 | -2931 | -8607 | -8362 |
| RPL39L | -8506 | -1648 | -4731 |
| RPL3L | 4458 | 5102 | 10556 |
| RPL4 | -3476 | -9521 | -7062 |
| RPL41 | -6632 | -7535 | -8456 |
| RPL5 | -4576 | -9853 | -7157 |
| RPL6 | -3262 | -9281 | -3434 |
| RPL7 | -1917 | -9737 | -8087 |
| RPL7A | -3557 | -8259 | -8751 |
| RPL8 | -1171 | -6076 | -8899 |
| RPL9 | -1837 | -6796 | -4391 |
| RPLP0 | -987 | -9199 | -8702 |
| RPLP1 | 19 | -5994 | -8833 |
| RPLP2 | -6844 | -9135 | -9001 |
| RPS10 | -5601 | -8466 | -8823 |
| RPS11 | -6992 | -7948 | -8743 |
| RPS12 | -5788 | -9242 | -8852 |
| RPS13 | -1717 | -8696 | -7869 |
| RPS14 | -5278 | -8513 | -8637 |
| RPS15 | -3565 | -6678 | -8273 |
| RPS15A | -5550 | -8855 | -8431 |
| RPS16 | -4518 | -8551 | -8704 |
| RPS17 | -6038 | -8254 | -8928 |
| RPS18 | -7474 | -8294 | -7671 |
| RPS19 | -6725 | -7779 | -8460 |
| RPS2 | -4354 | -9563 | -9021 |
| RPS20 | -8585 | -9385 | -6156 |
| RPS21 | -3952 | -8303 | -8855 |
| RPS23 | -6081 | -9359 | -8319 |
| RPS24 | -261 | -6793 | -4573 |
| RPS25 | -6151 | -9636 | -7764 |
| RPS26 | -1410 | -1143 | -462 |
| RPS27 | -9432 | -9147 | -8693 |
| RPS27A | -6700 | -9695 | -8668 |
| RPS27L | 2048 | -490 | 9654 |
| RPS28 | -4562 | -8056 | -8562 |
| RPS29 | -7664 | -8609 | -8958 |
| RPS3 | -5717 | -9270 | -8726 |
| RPS3A | -4543 | -9806 | -4045 |
| RPS4X | -6075 | -8620 | -4665 |
| RPS4Y1 | 418 | 329 | 1713 |
| RPS5 | -5502 | -9014 | -8342 |
| RPS6 | -5956 | -9671 | -7892 |
| RPS7 | -4803 | -9137 | -7874 |
| RPS8 | -2041 | -8833 | -6710 |
| RPS9 | 5358 | 1826 | -8433 |
| RPSA | -6110 | -6604 | 3504 |
| SEC13 | 5675 | 7411 | -5667 |
| SEH1L | -5868 | -9546 | 7736 |
| SLC25A6 | 6178 | -5564 | -9035 |
| TGFB1 | 5094 | 5452 | -7584 |
| TPR | -6786 | -3724 | 8739 |
| UBA52 | 1112 | -3471 | -8207 |
| XPO1 | -1169 | -3195 | 11634 |
IRAK1 recruits IKK complex
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.029 |
| p.adjustMANOVA | 0.0522 |
| s.dist | 0.699 |
| s.t0_v_pod | 0.533 |
| s.pod_crp | 0.404 |
| s.t0_crp | -0.203 |
| p.t0_v_pod | 0.00352 |
| p.pod_crp | 0.0271 |
| p.t0_crp | 0.267 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| PELI3 | 7600 | 8988 |
| CHUK | 7844 | 8599 |
| PELI2 | 8183 | 6100 |
| IKBKG | 5315 | 9298 |
| IRAK1 | 6047 | 7868 |
| PELI1 | 6623 | 4760 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CHUK | 7844 | 8599 | 3409 |
| IKBKB | -5208 | 1744 | -158 |
| IKBKG | 5315 | 9298 | -5591 |
| IRAK1 | 6047 | 7868 | -7655 |
| PELI1 | 6623 | 4760 | 2085 |
| PELI2 | 8183 | 6100 | -2290 |
| PELI3 | 7600 | 8988 | -8891 |
| TRAF6 | -229 | 4631 | 6648 |
| UBE2N | 1923 | -2057 | 7242 |
| UBE2V1 | 5568 | -1241 | 73 |
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.029 |
| p.adjustMANOVA | 0.0522 |
| s.dist | 0.699 |
| s.t0_v_pod | 0.533 |
| s.pod_crp | 0.404 |
| s.t0_crp | -0.203 |
| p.t0_v_pod | 0.00352 |
| p.pod_crp | 0.0271 |
| p.t0_crp | 0.267 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| PELI3 | 7600 | 8988 |
| CHUK | 7844 | 8599 |
| PELI2 | 8183 | 6100 |
| IKBKG | 5315 | 9298 |
| IRAK1 | 6047 | 7868 |
| PELI1 | 6623 | 4760 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CHUK | 7844 | 8599 | 3409 |
| IKBKB | -5208 | 1744 | -158 |
| IKBKG | 5315 | 9298 | -5591 |
| IRAK1 | 6047 | 7868 | -7655 |
| PELI1 | 6623 | 4760 | 2085 |
| PELI2 | 8183 | 6100 | -2290 |
| PELI3 | 7600 | 8988 | -8891 |
| TRAF6 | -229 | 4631 | 6648 |
| UBE2N | 1923 | -2057 | 7242 |
| UBE2V1 | 5568 | -1241 | 73 |
Smooth Muscle Contraction
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 2.08e-06 |
| p.adjustMANOVA | 1.42e-05 |
| s.dist | 0.698 |
| s.t0_v_pod | 0.494 |
| s.pod_crp | 0.369 |
| s.t0_crp | -0.329 |
| p.t0_v_pod | 1.95e-06 |
| p.pod_crp | 0.000381 |
| p.t0_crp | 0.00153 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| DYSF | 9303 | 11209 |
| ANXA2 | 8405 | 10514 |
| MYL6B | 8049 | 10602 |
| MYL6 | 8436 | 10011 |
| TLN1 | 8386 | 10017 |
| ITGA1 | 8585 | 9368 |
| PAK1 | 8100 | 9873 |
| TPM3 | 7927 | 9850 |
| TPM4 | 9085 | 8573 |
| PAK2 | 8056 | 8912 |
| PXN | 6144 | 9961 |
| VCL | 7218 | 6129 |
| CALD1 | 8086 | 5462 |
| TPM1 | 7918 | 5288 |
| ANXA1 | 7722 | 5179 |
| MYL12A | 6801 | 5368 |
| MYL12B | 5029 | 5646 |
| MYL5 | 3245 | 6615 |
| ITGB5 | 6823 | 2971 |
| MYL9 | 7587 | 1915 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ACTA2 | -426 | -157 | -1984 |
| ANXA1 | 7722 | 5179 | -7190 |
| ANXA2 | 8405 | 10514 | -659 |
| ANXA6 | 325 | 4237 | -7210 |
| CALD1 | 8086 | 5462 | -2715 |
| CALM1 | -2039 | -1234 | 3538 |
| DYSF | 9303 | 11209 | -1125 |
| GUCY1B2 | -4887 | -5571 | -2578 |
| ITGA1 | 8585 | 9368 | 3499 |
| ITGB5 | 6823 | 2971 | -5811 |
| MYH11 | -3419 | -2228 | 6330 |
| MYL12A | 6801 | 5368 | -1845 |
| MYL12B | 5029 | 5646 | -3168 |
| MYL5 | 3245 | 6615 | -1221 |
| MYL6 | 8436 | 10011 | -8786 |
| MYL6B | 8049 | 10602 | -33 |
| MYL9 | 7587 | 1915 | -4389 |
| MYLK | 6528 | 1255 | -1100 |
| MYLPF | -8570 | -6318 | -3584 |
| PAK1 | 8100 | 9873 | 7050 |
| PAK2 | 8056 | 8912 | 4639 |
| PXN | 6144 | 9961 | -7143 |
| SORBS1 | 1465 | 8839 | 1248 |
| SORBS3 | -10631 | -10071 | -8082 |
| TLN1 | 8386 | 10017 | -6948 |
| TPM1 | 7918 | 5288 | -4678 |
| TPM2 | -8870 | -7925 | -4857 |
| TPM3 | 7927 | 9850 | 2062 |
| TPM4 | 9085 | 8573 | -6015 |
| TRIM72 | 1866 | 4978 | 10002 |
| VCL | 7218 | 6129 | -4751 |
Signal transduction by L1
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000429 |
| p.adjustMANOVA | 0.00144 |
| s.dist | 0.698 |
| s.t0_v_pod | 0.438 |
| s.pod_crp | 0.507 |
| s.t0_crp | -0.194 |
| p.t0_v_pod | 0.00069 |
| p.pod_crp | 8.61e-05 |
| p.t0_crp | 0.132 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| RAC1 | 10438 | 8647 |
| MAP2K1 | 9974 | 8910 |
| MAPK3 | 9593 | 8803 |
| MAPK1 | 10983 | 7381 |
| PAK1 | 9873 | 8100 |
| ITGA5 | 9684 | 7543 |
| ITGA2B | 7297 | 8744 |
| CSNK2A1 | 8910 | 6113 |
| ITGA9 | 7707 | 6840 |
| MAP2K2 | 7135 | 6699 |
| ITGAV | 7746 | 6022 |
| CSNK2A2 | 7252 | 6301 |
| ITGB3 | 2918 | 8161 |
| CSNK2B | 5816 | 3930 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CSNK2A1 | 6113 | 8910 | 2123 |
| CSNK2A2 | 6301 | 7252 | 2705 |
| CSNK2B | 3930 | 5816 | -2975 |
| FGFR1 | -5175 | 6536 | 3650 |
| ITGA2B | 8744 | 7297 | -5705 |
| ITGA5 | 7543 | 9684 | -8177 |
| ITGA9 | 6840 | 7707 | 250 |
| ITGAV | 6022 | 7746 | 1880 |
| ITGB1 | -94 | -3054 | 6089 |
| ITGB3 | 8161 | 2918 | -7520 |
| L1CAM | -6144 | -3106 | 10087 |
| MAP2K1 | 8910 | 9974 | -7128 |
| MAP2K2 | 6699 | 7135 | -8945 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| NCAM1 | -11351 | -5120 | -7102 |
| NRP1 | -8419 | 6156 | 10552 |
| PAK1 | 8100 | 9873 | 7050 |
| RAC1 | 8647 | 10438 | 3441 |
| VAV2 | -3931 | 2731 | 1831 |
Cargo concentration in the ER
| metric | value |
|---|---|
| setSize | 30 |
| pMANOVA | 1.41e-05 |
| p.adjustMANOVA | 7.42e-05 |
| s.dist | 0.697 |
| s.t0_v_pod | 0.52 |
| s.pod_crp | 0.463 |
| s.t0_crp | -0.0357 |
| p.t0_v_pod | 8.05e-07 |
| p.pod_crp | 1.14e-05 |
| p.t0_crp | 0.735 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| F5 | 9324 | 11214 |
| SERPINA1 | 9013 | 11191 |
| TGFA | 8740 | 10781 |
| CTSZ | 8825 | 9776 |
| SEC24D | 7988 | 10607 |
| SEC24A | 7544 | 9271 |
| LMAN2 | 6976 | 9335 |
| PREB | 6281 | 10184 |
| STX5 | 7060 | 8427 |
| F8 | 6919 | 7922 |
| SEC23A | 7225 | 7044 |
| COL7A1 | 6218 | 7869 |
| MIA2 | 5506 | 8089 |
| SAR1B | 6391 | 6817 |
| SEC22B | 5797 | 6207 |
| MCFD2 | 6995 | 5086 |
| TMED2 | 5971 | 5294 |
| SEC24B | 3576 | 7263 |
| CD59 | 5783 | 4214 |
| CTSC | 2312 | 9136 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AREG | 5897 | 2368 | -7756 |
| CD59 | 5783 | 4214 | -5137 |
| CNIH1 | 7662 | -2681 | -3990 |
| CNIH2 | 648 | 4148 | 3099 |
| CNIH3 | -8703 | -4413 | -4085 |
| COL7A1 | 6218 | 7869 | -7155 |
| CTSC | 2312 | 9136 | 1722 |
| CTSZ | 8825 | 9776 | -7490 |
| F5 | 9324 | 11214 | 2591 |
| F8 | 6919 | 7922 | 3429 |
| GOSR2 | -1435 | 5925 | 9218 |
| LMAN1 | -10289 | -8494 | 11039 |
| LMAN2 | 6976 | 9335 | -5645 |
| LMAN2L | 6837 | 1573 | -7399 |
| MCFD2 | 6995 | 5086 | -3771 |
| MIA2 | 5506 | 8089 | 11791 |
| MIA3 | -6036 | -3666 | 10964 |
| PREB | 6281 | 10184 | -4539 |
| SAR1B | 6391 | 6817 | 12088 |
| SEC22B | 5797 | 6207 | 11141 |
| SEC23A | 7225 | 7044 | 5580 |
| SEC24A | 7544 | 9271 | 7048 |
| SEC24B | 3576 | 7263 | 6566 |
| SEC24C | -2506 | 8866 | -1909 |
| SEC24D | 7988 | 10607 | 5650 |
| SERPINA1 | 9013 | 11191 | 4539 |
| STX5 | 7060 | 8427 | -7349 |
| TGFA | 8740 | 10781 | -5172 |
| TMED10 | 321 | -4392 | -3223 |
| TMED2 | 5971 | 5294 | 6374 |
GRB2:SOS provides linkage to MAPK signaling for Integrins
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00325 |
| p.adjustMANOVA | 0.00812 |
| s.dist | 0.697 |
| s.t0_v_pod | 0.581 |
| s.pod_crp | 0.325 |
| s.t0_crp | -0.208 |
| p.t0_v_pod | 0.000497 |
| p.pod_crp | 0.051 |
| p.t0_crp | 0.212 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| GRB2 | 9146 | 10542 |
| APBB1IP | 8600 | 10436 |
| TLN1 | 8386 | 10017 |
| ITGA2B | 8744 | 7297 |
| RAP1A | 7198 | 7246 |
| VWF | 6550 | 3834 |
| ITGB3 | 8161 | 2918 |
| RAP1B | 3179 | 6882 |
| PTK2 | 4418 | 385 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| APBB1IP | 8600 | 10436 | -610 |
| FN1 | 8154 | -1816 | 4140 |
| GRB2 | 9146 | 10542 | -5185 |
| ITGA2B | 8744 | 7297 | -5705 |
| ITGB3 | 8161 | 2918 | -7520 |
| PTK2 | 4418 | 385 | -619 |
| RAP1A | 7198 | 7246 | 9059 |
| RAP1B | 3179 | 6882 | 6183 |
| SOS1 | -5511 | -2964 | 11031 |
| SRC | -8520 | -6371 | -3347 |
| TLN1 | 8386 | 10017 | -6948 |
| VWF | 6550 | 3834 | -7272 |
Transferrin endocytosis and recycling
| metric | value |
|---|---|
| setSize | 26 |
| pMANOVA | 2.18e-05 |
| p.adjustMANOVA | 0.000106 |
| s.dist | 0.696 |
| s.t0_v_pod | 0.509 |
| s.pod_crp | 0.37 |
| s.t0_crp | -0.298 |
| p.t0_v_pod | 7.03e-06 |
| p.pod_crp | 0.00109 |
| p.t0_crp | 0.00847 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| ATP6V0A1 | 9262 | 11071 |
| ATP6V0D1 | 9088 | 10812 |
| ATP6V0C | 8974 | 10793 |
| ATP6AP1 | 8032 | 11126 |
| ATP6V1D | 8894 | 9815 |
| ATP6V1A | 9144 | 9387 |
| ATP6V1B2 | 8904 | 9293 |
| ATP6V1C1 | 8400 | 9733 |
| ATP6V0B | 8458 | 9622 |
| MCOLN1 | 7624 | 10550 |
| TCIRG1 | 7082 | 10931 |
| ATP6V0E1 | 8456 | 8299 |
| ATP6V1E1 | 7912 | 8087 |
| STEAP3 | 5915 | 9626 |
| ATP6V1H | 7939 | 7019 |
| ATP6V1F | 5802 | 3776 |
| HFE | 8632 | 1838 |
| TFRC | 1513 | 4799 |
| TF | 1093 | 1234 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ATP6AP1 | 8032 | 11126 | -8542 |
| ATP6V0A1 | 9262 | 11071 | -4129 |
| ATP6V0A2 | -11850 | -6562 | 10591 |
| ATP6V0B | 8458 | 9622 | -7822 |
| ATP6V0C | 8974 | 10793 | -5635 |
| ATP6V0D1 | 9088 | 10812 | -6200 |
| ATP6V0E1 | 8456 | 8299 | -6597 |
| ATP6V0E2 | -11202 | -9428 | 81 |
| ATP6V1A | 9144 | 9387 | 639 |
| ATP6V1B2 | 8904 | 9293 | -2076 |
| ATP6V1C1 | 8400 | 9733 | 1842 |
| ATP6V1C2 | -2175 | -2908 | 1018 |
| ATP6V1D | 8894 | 9815 | 2539 |
| ATP6V1E1 | 7912 | 8087 | 1529 |
| ATP6V1E2 | 5657 | -3873 | -6954 |
| ATP6V1F | 5802 | 3776 | -8689 |
| ATP6V1G1 | 3892 | -4753 | -2897 |
| ATP6V1G2 | -9197 | -9115 | 3143 |
| ATP6V1H | 7939 | 7019 | -2464 |
| HFE | 8632 | 1838 | -1502 |
| MCOLN1 | 7624 | 10550 | -5540 |
| STEAP3 | 5915 | 9626 | -3861 |
| TCIRG1 | 7082 | 10931 | -5721 |
| TF | 1093 | 1234 | 5787 |
| TFR2 | -9464 | -3974 | -88 |
| TFRC | 1513 | 4799 | 11773 |
EPHB-mediated forward signaling
| metric | value |
|---|---|
| setSize | 32 |
| pMANOVA | 8.88e-06 |
| p.adjustMANOVA | 5.05e-05 |
| s.dist | 0.696 |
| s.t0_v_pod | 0.504 |
| s.pod_crp | 0.475 |
| s.t0_crp | -0.067 |
| p.t0_v_pod | 8.17e-07 |
| p.pod_crp | 3.24e-06 |
| p.t0_crp | 0.512 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| ARPC1B | 9102 | 10587 |
| ITSN1 | 9131 | 10546 |
| ARPC1A | 8745 | 10779 |
| ACTB | 8859 | 10421 |
| RAC1 | 8647 | 10438 |
| ARPC5 | 8544 | 9930 |
| LYN | 7691 | 10614 |
| ACTG1 | 8423 | 9524 |
| PAK1 | 8100 | 9873 |
| CFL1 | 8057 | 9633 |
| RHOA | 8188 | 9259 |
| LIMK2 | 7949 | 9535 |
| ARPC3 | 8147 | 8602 |
| ARPC4 | 7404 | 9441 |
| ACTR2 | 7750 | 8769 |
| ACTR3 | 7699 | 8747 |
| ARPC2 | 7280 | 8886 |
| ROCK1 | 7377 | 8572 |
| CDC42 | 7425 | 8226 |
| ROCK2 | 6054 | 6540 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ACTB | 8859 | 10421 | -4561 |
| ACTG1 | 8423 | 9524 | -7556 |
| ACTR2 | 7750 | 8769 | 5308 |
| ACTR3 | 7699 | 8747 | 3145 |
| ARHGEF28 | -9954 | 2366 | 6119 |
| ARPC1A | 8745 | 10779 | 2238 |
| ARPC1B | 9102 | 10587 | -8003 |
| ARPC2 | 7280 | 8886 | -214 |
| ARPC3 | 8147 | 8602 | 3314 |
| ARPC4 | 7404 | 9441 | -4920 |
| ARPC5 | 8544 | 9930 | 1879 |
| CDC42 | 7425 | 8226 | 5599 |
| CFL1 | 8057 | 9633 | -8162 |
| FYN | -11320 | -5187 | -4239 |
| HRAS | -3288 | -5249 | -5447 |
| ITSN1 | 9131 | 10546 | 7645 |
| KALRN | -3584 | -8050 | -3602 |
| LIMK1 | 4628 | 7956 | -5779 |
| LIMK2 | 7949 | 9535 | -1036 |
| LYN | 7691 | 10614 | 7111 |
| PAK1 | 8100 | 9873 | 7050 |
| PTK2 | 4418 | 385 | -619 |
| RAC1 | 8647 | 10438 | 3441 |
| RASA1 | 2093 | 6185 | 10904 |
| RHOA | 8188 | 9259 | -372 |
| ROCK1 | 7377 | 8572 | 9620 |
| ROCK2 | 6054 | 6540 | 7093 |
| SDC2 | 5335 | 2307 | 307 |
| SRC | -8520 | -6371 | -3347 |
| TIAM1 | 645 | -3498 | -4756 |
| WASL | 297 | 3268 | 7557 |
| YES1 | -11781 | -2829 | 4373 |
Nucleobase biosynthesis
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00259 |
| p.adjustMANOVA | 0.00678 |
| s.dist | 0.696 |
| s.t0_v_pod | -0.356 |
| s.pod_crp | -0.578 |
| s.t0_crp | -0.152 |
| p.t0_v_pod | 0.0263 |
| p.pod_crp | 0.000306 |
| p.t0_crp | 0.343 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| ATIC | -10033 | -10848 |
| PPAT | -9990 | -10811 |
| UMPS | -9953 | -10137 |
| PFAS | -9357 | -10685 |
| IMPDH2 | -10097 | -9588 |
| CAD | -8790 | -9437 |
| PAICS | -9426 | -5189 |
| DHODH | -5949 | -5446 |
| GMPS | -5172 | -5248 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| ADSL | 5026 | -6357 | -5016 |
| ATIC | -10848 | -10033 | 3861 |
| CAD | -9437 | -8790 | 108 |
| DHODH | -5446 | -5949 | -1359 |
| GART | -3463 | 4522 | 11398 |
| GMPS | -5248 | -5172 | 4941 |
| IMPDH1 | 9136 | 11090 | -5341 |
| IMPDH2 | -9588 | -10097 | -8492 |
| LHPP | 11 | -3554 | -3618 |
| PAICS | -5189 | -9426 | 6536 |
| PFAS | -10685 | -9357 | -6662 |
| PPAT | -10811 | -9990 | 6064 |
| UMPS | -10137 | -9953 | -1981 |
AKT phosphorylates targets in the cytosol
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.00448 |
| p.adjustMANOVA | 0.0107 |
| s.dist | 0.695 |
| s.t0_v_pod | 0.427 |
| s.pod_crp | 0.444 |
| s.t0_crp | -0.322 |
| p.t0_v_pod | 0.00563 |
| p.pod_crp | 0.00405 |
| p.t0_crp | 0.0368 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| CASP9 | 10977 | 7569 |
| GSK3A | 9812 | 7643 |
| CHUK | 8599 | 7844 |
| AKT1S1 | 8292 | 7745 |
| MKRN1 | 6512 | 8671 |
| BAD | 7176 | 6794 |
| GSK3B | 7062 | 6543 |
| MDM2 | 5980 | 4268 |
| CDKN1A | 5485 | 4466 |
| AKT1 | 6430 | 3582 |
| AKT2 | 5450 | 427 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AKT1 | 3582 | 6430 | -8210 |
| AKT1S1 | 7745 | 8292 | -8660 |
| AKT2 | 427 | 5450 | -7867 |
| AKT3 | -11493 | -8782 | 2868 |
| BAD | 6794 | 7176 | -8894 |
| CASP9 | 7569 | 10977 | 362 |
| CDKN1A | 4466 | 5485 | 454 |
| CDKN1B | -7924 | -3108 | -677 |
| CHUK | 7844 | 8599 | 3409 |
| GSK3A | 7643 | 9812 | -6274 |
| GSK3B | 6543 | 7062 | -1469 |
| MDM2 | 4268 | 5980 | 12082 |
| MKRN1 | 8671 | 6512 | -52 |
| TSC2 | -798 | 4273 | -2115 |
GAB1 signalosome
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 0.00142 |
| p.adjustMANOVA | 0.00403 |
| s.dist | 0.695 |
| s.t0_v_pod | 0.471 |
| s.pod_crp | 0.301 |
| s.t0_crp | -0.413 |
| p.t0_v_pod | 0.00159 |
| p.pod_crp | 0.0433 |
| p.t0_crp | 0.00558 |
| Gene | t0_v_pod | t0_crp |
|---|---|---|
| GRB2 | 9146 | -5185 |
| AREG | 5897 | -7756 |
| EGF | 8050 | -5617 |
| TGFA | 8740 | -5172 |
| PXN | 6144 | -7143 |
| HBEGF | 4954 | -8152 |
| CSK | 5158 | -7001 |
| EREG | 1875 | -7212 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| AREG | 5897 | 2368 | -7756 |
| CSK | 5158 | 9258 | -7001 |
| EGF | 8050 | 5218 | -5617 |
| EPGN | 2642 | -1230 | 1721 |
| EREG | 1875 | -246 | -7212 |
| GAB1 | 5607 | 8548 | 9775 |
| GRB2 | 9146 | 10542 | -5185 |
| HBEGF | 4954 | 2048 | -8152 |
| PAG1 | 5207 | 5991 | 810 |
| PIK3CA | 4580 | 2117 | 7009 |
| PIK3R1 | -9187 | -8803 | -5081 |
| PTPN11 | 5253 | 6456 | 949 |
| PXN | 6144 | 9961 | -7143 |
| SRC | -8520 | -6371 | -3347 |
| TGFA | 8740 | 10781 | -5172 |
MAP2K and MAPK activation
| metric | value |
|---|---|
| setSize | 34 |
| pMANOVA | 1.53e-06 |
| p.adjustMANOVA | 1.08e-05 |
| s.dist | 0.694 |
| s.t0_v_pod | 0.516 |
| s.pod_crp | 0.405 |
| s.t0_crp | -0.225 |
| p.t0_v_pod | 1.87e-07 |
| p.pod_crp | 4.36e-05 |
| p.t0_crp | 0.023 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| MARK3 | 8555 | 10592 |
| APBB1IP | 8600 | 10436 |
| MAP2K1 | 8910 | 9974 |
| ARRB2 | 8355 | 10498 |
| MAPK3 | 8803 | 9593 |
| TLN1 | 8386 | 10017 |
| MAPK1 | 7381 | 10983 |
| IQGAP1 | 8024 | 9867 |
| RAF1 | 7759 | 9532 |
| ITGA2B | 8744 | 7297 |
| LAMTOR2 | 7454 | 7902 |
| RAP1A | 7198 | 7246 |
| MAP2K2 | 6699 | 7135 |
| CSK | 5158 | 9258 |
| VCL | 7218 | 6129 |
| KSR1 | 4126 | 10392 |
| LAMTOR3 | 7461 | 5332 |
| YWHAB | 6298 | 4679 |
| NRAS | 5302 | 4863 |
| VWF | 6550 | 3834 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| APBB1IP | 8600 | 10436 | -610 |
| ARAF | 2624 | 6025 | -5160 |
| ARRB1 | 1985 | 3920 | -7962 |
| ARRB2 | 8355 | 10498 | -7583 |
| BRAF | 1298 | 4328 | 6880 |
| CNKSR1 | -6846 | -8211 | 3517 |
| CNKSR2 | -4628 | -4445 | 5043 |
| CSK | 5158 | 9258 | -7001 |
| FN1 | 8154 | -1816 | 4140 |
| HRAS | -3288 | -5249 | -5447 |
| IQGAP1 | 8024 | 9867 | -3260 |
| ITGA2B | 8744 | 7297 | -5705 |
| ITGB3 | 8161 | 2918 | -7520 |
| KRAS | 3668 | 6068 | 10842 |
| KSR1 | 4126 | 10392 | 3433 |
| KSR2 | -3268 | 227 | 3301 |
| LAMTOR2 | 7454 | 7902 | -8721 |
| LAMTOR3 | 7461 | 5332 | 7456 |
| MAP2K1 | 8910 | 9974 | -7128 |
| MAP2K2 | 6699 | 7135 | -8945 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| MARK3 | 8555 | 10592 | 9836 |
| NRAS | 5302 | 4863 | 8490 |
| PEBP1 | -10920 | -9815 | 2352 |
| RAF1 | 7759 | 9532 | -1258 |
| RAP1A | 7198 | 7246 | 9059 |
| RAP1B | 3179 | 6882 | 6183 |
| SRC | -8520 | -6371 | -3347 |
| TLN1 | 8386 | 10017 | -6948 |
| VCL | 7218 | 6129 | -4751 |
| VWF | 6550 | 3834 | -7272 |
| WDR83 | 3684 | 5880 | -5672 |
| YWHAB | 6298 | 4679 | 8802 |
ERKs are inactivated
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00696 |
| p.adjustMANOVA | 0.0154 |
| s.dist | 0.694 |
| s.t0_v_pod | 0.432 |
| s.pod_crp | 0.41 |
| s.t0_crp | -0.355 |
| p.t0_v_pod | 0.00697 |
| p.pod_crp | 0.0104 |
| p.t0_crp | 0.0266 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| MAPK3 | 8803 | 9593 |
| MAPK1 | 7381 | 10983 |
| DUSP3 | 9122 | 8391 |
| PPP2CB | 7596 | 7359 |
| PPP2CA | 8104 | 6731 |
| PPP2R1A | 4542 | 5140 |
| PPP2R5D | 2405 | 6530 |
| VRK3 | 1271 | 7119 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| DUSP3 | 9122 | 8391 | -6855 |
| DUSP4 | -6077 | -2102 | -2865 |
| DUSP6 | 4313 | -3036 | 669 |
| DUSP7 | -3126 | -2437 | -6062 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| MAPK7 | -1318 | 9865 | -4166 |
| PPP2CA | 8104 | 6731 | -306 |
| PPP2CB | 7596 | 7359 | 4715 |
| PPP2R1A | 4542 | 5140 | -7934 |
| PPP2R1B | -241 | 88 | 5847 |
| PPP2R5D | 2405 | 6530 | -1893 |
| VRK3 | 1271 | 7119 | 1541 |
Signal regulatory protein family interactions
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00777 |
| p.adjustMANOVA | 0.0171 |
| s.dist | 0.689 |
| s.t0_v_pod | 0.409 |
| s.pod_crp | 0.343 |
| s.t0_crp | -0.437 |
| p.t0_v_pod | 0.0143 |
| p.pod_crp | 0.0396 |
| p.t0_crp | 0.0088 |
| Gene | t0_crp | t0_v_pod |
|---|---|---|
| SIRPA | -7771 | 9348 |
| SIRPB1 | -7813 | 7723 |
| PTK2B | -7454 | 7814 |
| TYROBP | -6868 | 7427 |
| GRB2 | -5185 | 9146 |
| PTPN6 | -797 | 6014 |
| SKAP2 | -484 | 9139 |
| PTK2 | -619 | 4418 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CD47 | -11753 | -9136 | 9265 |
| GRB2 | 9146 | 10542 | -5185 |
| PTK2 | 4418 | 385 | -619 |
| PTK2B | 7814 | 10976 | -7454 |
| PTPN11 | 5253 | 6456 | 949 |
| PTPN6 | 6014 | 10265 | -797 |
| SIRPA | 9348 | 11197 | -7771 |
| SIRPB1 | 7723 | 7051 | -7813 |
| SIRPG | -9557 | -10115 | -6013 |
| SKAP2 | 9139 | 9949 | -484 |
| SRC | -8520 | -6371 | -3347 |
| TYROBP | 7427 | 9484 | -6868 |
Prolonged ERK activation events
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0133 |
| p.adjustMANOVA | 0.0271 |
| s.dist | 0.687 |
| s.t0_v_pod | 0.452 |
| s.pod_crp | 0.514 |
| s.t0_crp | -0.0617 |
| p.t0_v_pod | 0.0048 |
| p.pod_crp | 0.00132 |
| p.t0_crp | 0.7 |
| Gene | pod_crp | t0_v_pod |
|---|---|---|
| CRK | 10207 | 8756 |
| MAP2K1 | 9974 | 8910 |
| MAPK3 | 9593 | 8803 |
| MAPK1 | 10983 | 7381 |
| KIDINS220 | 9198 | 6965 |
| RAP1A | 7246 | 7198 |
| MAP2K2 | 7135 | 6699 |
| YWHAB | 4679 | 6298 |
| CRKL | 5201 | 3927 |
| BRAF | 4328 | 1298 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| BRAF | 1298 | 4328 | 6880 |
| CRK | 8756 | 10207 | 5223 |
| CRKL | 3927 | 5201 | -2305 |
| FRS2 | -3337 | -1133 | 7109 |
| KIDINS220 | 6965 | 9198 | 3097 |
| MAP2K1 | 8910 | 9974 | -7128 |
| MAP2K2 | 6699 | 7135 | -8945 |
| MAPK1 | 7381 | 10983 | -1505 |
| MAPK3 | 8803 | 9593 | -9014 |
| NTRK1 | -7910 | -3772 | 7353 |
| RAP1A | 7198 | 7246 | 9059 |
| RAPGEF1 | -9501 | 5055 | -5674 |
| YWHAB | 6298 | 4679 | 8802 |
Endosomal Sorting Complex Required For Transport (ESCRT)
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 1.02e-05 |
| p.adjustMANOVA | 5.57e-05 |
| s.dist | 0.687 |
| s.t0_v_pod | 0.519 |
| s.pod_crp | 0.381 |
| s.t0_crp | -0.238 |
| p.t0_v_pod | 1.28e-06 |
| p.pod_crp | 0.000382 |
| p.t0_crp | 0.0265 |
| Gene | t0_v_pod | pod_crp |
|---|---|---|
| UBAP1 | 8559 | 10174 |
| CHMP4B | 8718 | 9980 |
| CHMP2A | 8635 | 10030 |
| VPS37C | 7888 | 10221 |
| VPS25 | 7522 | 9304 |
| CHMP3 | 8217 | 8485 |
| TSG101 | 7669 | 7800 |
| VPS37A | 6379 | 8637 |
| MVB12A | 7290 | 6903 |
| CHMP5 | 4886 | 9864 |
| STAM2 | 6075 | 7339 |
| MVB12B | 5115 | 8610 |
| CHMP6 | 5434 | 7713 |
| HGS | 4468 | 9176 |
| VPS37B | 3869 | 8493 |
| SNF8 | 5893 | 5369 |
| UBC | 4395 | 6071 |
| VPS4B | 5151 | 4876 |
| VTA1 | 6101 | 3904 |
| CHMP2B | 5641 | 3060 |
Click HERE to show all gene set members
| t0_v_pod | pod_crp | t0_crp | |
|---|---|---|---|
| CHMP2A | 8635 | 10030 | -7692 |
| CHMP2B | 5641 | 3060 | 6804 |
| CHMP3 | 8217 | 8485 | 705 |
| CHMP4A | 2384 | 3434 | 4816 |
| CHMP4B | 8718 | 9980 | -8710 |
| CHMP5 | 4886 | 9864 | 11784 |
| CHMP6 | 5434 | 7713 | -8792 |
| CHMP7 | -8503 | -9011 | -215 |
| HGS | 4468 | 9176 | -507 |
| MVB12A | 7290 | 6903 | -8242 |
| MVB12B | 5115 | 8610 | -695 |
| RPS27A | -6700 | -9695 | -8668 |
| SNF8 | 5893 | 5369 | -7548 |
| STAM | 1275 | 898 | 3823 |
| STAM2 | 6075 | 7339 | 11256 |
| TSG101 | 7669 | 7800 | 4356 |
| UBA52 | 1112 | -3471 | -8207 |
| UBAP1 | 8559 | 10174 | -5375 |
| UBB | 6548 | 1016 | -6697 |
| UBC | 4395 | 6071 | -4003 |
| VPS25 | 7522 | 9304 | -6721 |
| VPS28 | 4156 | -749 | -8515 |
| VPS36 | -6615 | -4475 | 11400 |
| VPS37A | 6379 | 8637 | 9727 |
| VPS37B | 3869 | 8493 | -7026 |
| VPS37C | 7888 | 10221 | -935 |
| VPS4A | 777 | 167 | -8270 |
| VPS4B | 5151 | 4876 | 7128 |
| VTA1 | 6101 | 3904 | 9297 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.1.0 GGally_2.0.0
## [3] beeswarm_0.2.3 gtools_3.8.2
## [5] echarts4r_0.3.2 mitch_1.0.6
## [7] MASS_7.3-52 fgsea_1.14.0
## [9] gplots_3.0.3 DESeq2_1.28.1
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0
## [13] matrixStats_0.56.0 Biobase_2.48.0
## [15] GenomicRanges_1.40.0 GenomeInfoDb_1.24.2
## [17] IRanges_2.22.2 S4Vectors_0.26.1
## [19] BiocGenerics_0.34.0 reshape2_1.4.4
## [21] forcats_0.5.0 stringr_1.4.0
## [23] dplyr_1.0.0 purrr_0.3.4
## [25] readr_1.3.1 tidyr_1.1.0
## [27] tibble_3.0.1 ggplot2_3.3.2
## [29] tidyverse_1.3.0
##
## loaded via a namespace (and not attached):
## [1] colorspace_1.4-1 ellipsis_0.3.1 rprojroot_1.3-2
## [4] XVector_0.28.0 fs_1.4.2 rstudioapi_0.11
## [7] farver_2.0.3 bit64_0.9-7 AnnotationDbi_1.50.1
## [10] fansi_0.4.1 lubridate_1.7.9 xml2_1.3.2
## [13] splines_4.0.2 geneplotter_1.66.0 knitr_1.29
## [16] jsonlite_1.7.0 broom_0.5.6 annotate_1.66.0
## [19] dbplyr_1.4.4 shiny_1.5.0 compiler_4.0.2
## [22] httr_1.4.1 backports_1.1.8 assertthat_0.2.1
## [25] Matrix_1.2-18 fastmap_1.0.1 cli_2.0.2
## [28] later_1.1.0.1 htmltools_0.5.0 tools_4.0.2
## [31] gtable_0.3.0 glue_1.4.1 GenomeInfoDbData_1.2.3
## [34] fastmatch_1.1-0 Rcpp_1.0.4.6 cellranger_1.1.0
## [37] vctrs_0.3.1 gdata_2.18.0 nlme_3.1-148
## [40] xfun_0.15 testthat_2.3.2 rvest_0.3.5
## [43] mime_0.9 lifecycle_0.2.0 XML_3.99-0.3
## [46] zlibbioc_1.34.0 scales_1.1.1 hms_0.5.3
## [49] promises_1.1.1 RColorBrewer_1.1-2 yaml_2.2.1
## [52] memoise_1.1.0 gridExtra_2.3 reshape_0.8.8
## [55] stringi_1.4.6 RSQLite_2.2.0 highr_0.8
## [58] genefilter_1.70.0 desc_1.2.0 caTools_1.18.0
## [61] BiocParallel_1.22.0 rlang_0.4.6 pkgconfig_2.0.3
## [64] bitops_1.0-6 evaluate_0.14 lattice_0.20-41
## [67] labeling_0.3 htmlwidgets_1.5.1 bit_1.1-15.2
## [70] tidyselect_1.1.0 plyr_1.8.6 magrittr_1.5
## [73] R6_2.4.1 generics_0.0.2 DBI_1.1.0
## [76] pillar_1.4.4 haven_2.3.1 withr_2.2.0
## [79] survival_3.2-3 RCurl_1.98-1.2 modelr_0.1.8
## [82] crayon_1.3.4 KernSmooth_2.23-17 rmarkdown_2.3
## [85] locfit_1.5-9.4 grid_4.0.2 readxl_1.3.1
## [88] data.table_1.12.8 blob_1.2.1 reprex_0.3.0
## [91] digest_0.6.25 pbmcapply_1.5.0 xtable_1.8-4
## [94] httpuv_1.5.4 munsell_0.5.0END of report