date generated: 2020-07-02

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##            t0_v_pod    pod_crp     t0_crp
## A1BG      2.6245484 -0.2700849 -3.3590111
## A1BG-AS1  0.4968992 -0.1338135 -0.7824907
## A1CF      0.5554787 -0.2637826  0.1338318
## A2M      -3.2184650 -0.9092766  1.2404397
## A2M-AS1  -3.0532140 -1.3532049  0.6133565
## A2ML1    -0.3470803  1.3356390  2.2932412

Here are some metrics about the input data profile:

Profile metrics
Profile metrics
num_genes_in_profile 21381
duplicated_genes_present 0
num_profile_genes_in_sets 8376
num_profile_genes_not_in_sets 13005

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
Gene sets metrics
num_genesets 2400
num_genesets_excluded 1040
num_genesets_included 1360

Genes by sector
t0_v_pod pod_crp t0_crp Count
1 -1 -1 -1 4679
2 1 -1 -1 655
3 -1 1 -1 626
4 0 1 -1 1
5 1 1 -1 3133
6 -1 1 0 1
7 -1 -1 1 4464
8 1 -1 1 543
9 -1 1 1 2199
10 1 1 1 5080
Number of significant gene sets (FDR<0.05)= 686

Gene sets by sector


Gene sets by sector
s.t0_v_pod s.pod_crp s.t0_crp Count
1 -1 -1 -1 118
2 1 -1 -1 42
3 -1 1 -1 2
4 1 1 -1 452
5 -1 -1 1 28
6 1 -1 1 1
7 -1 1 1 2
8 1 1 1 41

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 100 gene sets

set setSize pMANOVA p.adjustMANOVA s.dist s.t0_v_pod s.pod_crp s.t0_crp p.t0_v_pod p.pod_crp p.t0_crp
IRAK4 deficiency (TLR2/4) 10 7.84e-06 4.37e-05 1.280 0.8980 0.876 0.23500 8.77e-07 1.61e-06 1.98e-01
MyD88 deficiency (TLR2/4) 10 7.84e-06 4.37e-05 1.280 0.8980 0.876 0.23500 8.77e-07 1.61e-06 1.98e-01
Peptide chain elongation 88 2.05e-65 3.49e-63 1.150 -0.2850 -0.705 -0.86200 3.73e-06 2.46e-30 1.39e-44
Eukaryotic Translation Elongation 93 6.85e-69 2.33e-66 1.140 -0.2770 -0.701 -0.85700 3.91e-06 1.27e-31 1.65e-46
Viral mRNA Translation 88 1.89e-61 1.98e-59 1.110 -0.2660 -0.679 -0.83300 1.62e-05 3.14e-28 9.07e-42
Selenocysteine synthesis 92 2.28e-60 2.21e-58 1.100 -0.3030 -0.685 -0.80600 5.13e-07 5.82e-30 7.14e-41
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.99e-05 1.00e-04 1.100 0.7870 0.765 -0.00551 2.33e-06 4.40e-06 9.74e-01
alpha-linolenic acid (ALA) metabolism 12 1.99e-05 1.00e-04 1.100 0.7870 0.765 -0.00551 2.33e-06 4.40e-06 9.74e-01
Eukaryotic Translation Termination 92 4.92e-62 6.08e-60 1.090 -0.2680 -0.669 -0.82200 9.02e-06 1.18e-28 2.03e-42
Translocation of ZAP-70 to Immunological synapse 24 6.09e-10 6.84e-09 1.090 -0.7440 -0.737 -0.28500 2.80e-10 4.08e-10 1.56e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.13e-06 8.28e-06 1.080 0.6780 0.659 -0.52800 9.92e-05 1.54e-04 2.43e-03
Formation of a pool of free 40S subunits 100 6.51e-71 2.95e-68 1.070 -0.2120 -0.666 -0.80800 2.53e-04 1.06e-30 1.81e-44
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 4.90e-58 3.92e-56 1.040 -0.2480 -0.643 -0.77300 3.28e-05 3.79e-27 1.53e-38
Regulation of TLR by endogenous ligand 11 3.18e-04 1.15e-03 1.010 0.7420 0.677 0.06130 2.04e-05 9.99e-05 7.25e-01
Uptake and function of anthrax toxins 10 1.73e-04 6.82e-04 0.998 0.7040 0.641 -0.30100 1.16e-04 4.50e-04 9.93e-02
Hyaluronan uptake and degradation 10 4.53e-04 1.59e-03 0.996 0.7270 0.668 -0.13800 6.91e-05 2.56e-04 4.49e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.77e-53 1.33e-51 0.956 -0.2250 -0.603 -0.70700 9.85e-05 1.85e-25 1.84e-34
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.55e-67 1.24e-64 0.954 -0.1470 -0.590 -0.73500 7.91e-03 9.82e-27 1.13e-40
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.69e-65 3.28e-63 0.941 -0.1510 -0.586 -0.72100 6.10e-03 1.17e-26 1.85e-39
VLDLR internalisation and degradation 11 2.05e-06 1.35e-05 0.938 0.4670 0.591 -0.55900 7.35e-03 6.83e-04 1.33e-03
Advanced glycosylation endproduct receptor signaling 12 1.27e-04 5.12e-04 0.918 0.6500 0.576 -0.29900 9.67e-05 5.51e-04 7.30e-02
RNA Polymerase I Promoter Opening 19 3.80e-08 3.52e-07 0.908 0.6210 0.461 -0.47700 2.78e-06 5.07e-04 3.22e-04
Erythrocytes take up carbon dioxide and release oxygen 11 3.23e-04 1.16e-03 0.899 0.7200 0.513 -0.16200 3.54e-05 3.23e-03 3.53e-01
O2/CO2 exchange in erythrocytes 11 3.23e-04 1.16e-03 0.899 0.7200 0.513 -0.16200 3.54e-05 3.23e-03 3.53e-01
Cap-dependent Translation Initiation 118 2.14e-63 2.91e-61 0.894 -0.1350 -0.553 -0.69000 1.13e-02 3.07e-25 1.75e-38
Eukaryotic Translation Initiation 118 2.14e-63 2.91e-61 0.894 -0.1350 -0.553 -0.69000 1.13e-02 3.07e-25 1.75e-38
MET activates RAP1 and RAC1 10 4.50e-03 1.14e-02 0.880 0.5250 0.634 0.31100 4.06e-03 5.12e-04 8.87e-02
Selenoamino acid metabolism 114 3.53e-48 1.92e-46 0.867 -0.2320 -0.560 -0.62000 1.87e-05 4.62e-25 2.27e-30
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.41e-49 8.00e-48 0.866 -0.1990 -0.533 -0.65300 2.42e-04 8.00e-23 1.47e-33
Nonsense-Mediated Decay (NMD) 114 1.41e-49 8.00e-48 0.866 -0.1990 -0.533 -0.65300 2.42e-04 8.00e-23 1.47e-33
PD-1 signaling 28 2.25e-07 1.89e-06 0.863 -0.5780 -0.592 -0.24600 1.19e-07 5.91e-08 2.43e-02
Retrograde neurotrophin signalling 12 2.85e-04 1.05e-03 0.856 0.5660 0.559 -0.31600 6.82e-04 7.99e-04 5.78e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 7.74e-29 2.77e-27 0.855 -0.0856 -0.554 -0.64500 2.90e-01 7.55e-12 1.50e-15
WNT5A-dependent internalization of FZD4 13 7.41e-06 4.18e-05 0.848 0.4480 0.540 -0.47700 5.16e-03 7.52e-04 2.93e-03
RHO GTPases Activate ROCKs 18 5.18e-05 2.32e-04 0.848 0.5390 0.644 0.11300 7.45e-05 2.20e-06 4.08e-01
Unwinding of DNA 12 1.67e-03 4.91e-03 0.846 -0.6470 -0.536 -0.09350 1.04e-04 1.29e-03 5.75e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.84e-50 1.13e-48 0.843 -0.1370 -0.504 -0.66200 1.26e-02 4.08e-20 1.55e-33
Gap junction trafficking 13 2.38e-04 9.00e-04 0.842 0.5590 0.567 -0.27200 4.81e-04 3.97e-04 8.95e-02
RHO GTPases Activate WASPs and WAVEs 35 1.97e-09 2.07e-08 0.839 0.6060 0.575 -0.08110 5.50e-10 3.90e-09 4.07e-01
p130Cas linkage to MAPK signaling for integrins 11 1.70e-03 4.94e-03 0.833 0.6630 0.490 0.11300 1.39e-04 4.86e-03 5.15e-01
Influenza Viral RNA Transcription and Replication 135 6.97e-51 4.51e-49 0.828 -0.2280 -0.529 -0.59500 4.82e-06 2.38e-26 5.68e-33
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 8.54e-03 1.96e-02 0.820 0.5210 0.623 0.11000 4.32e-03 6.41e-04 5.48e-01
Platelet sensitization by LDL 16 3.63e-04 1.30e-03 0.814 0.5510 0.600 0.00436 1.37e-04 3.25e-05 9.76e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 8.40e-59 7.14e-57 0.808 -0.3090 -0.581 -0.46800 8.81e-13 2.00e-41 1.92e-27
rRNA processing in the nucleus and cytosol 190 1.37e-61 1.55e-59 0.808 -0.3090 -0.578 -0.47100 1.87e-13 3.52e-43 3.59e-29
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 3.79e-03 9.83e-03 0.792 0.5540 0.563 0.06160 5.47e-04 4.38e-04 7.01e-01
Phosphorylation of CD3 and TCR zeta chains 27 4.43e-06 2.71e-05 0.784 -0.5410 -0.514 -0.24000 1.12e-06 3.72e-06 3.08e-02
DNA methylation 20 7.80e-07 6.01e-06 0.784 0.5210 0.356 -0.46600 5.45e-05 5.86e-03 3.12e-04
Neutrophil degranulation 458 0.00e+00 0.00e+00 0.784 0.5850 0.507 -0.12500 0.00e+00 8.68e-78 4.92e-06
Trafficking of GluR2-containing AMPA receptors 12 4.81e-04 1.67e-03 0.780 0.4710 0.490 -0.38300 4.70e-03 3.29e-03 2.15e-02
Detoxification of Reactive Oxygen Species 32 2.21e-08 2.10e-07 0.779 0.5600 0.493 -0.22400 4.23e-08 1.37e-06 2.83e-02
RHO GTPases Activate NADPH Oxidases 21 1.22e-05 6.47e-05 0.775 0.5570 0.481 -0.24300 9.74e-06 1.36e-04 5.44e-02
COPI-independent Golgi-to-ER retrograde traffic 33 2.83e-07 2.33e-06 0.764 0.5610 0.518 -0.03410 2.44e-08 2.55e-07 7.35e-01
Translation initiation complex formation 58 2.52e-28 8.56e-27 0.758 -0.0222 -0.472 -0.59300 7.70e-01 5.10e-10 5.29e-15
rRNA processing 217 2.99e-60 2.71e-58 0.757 -0.2910 -0.529 -0.45600 1.46e-13 2.54e-41 4.11e-31
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.35e-03 1.11e-02 0.754 0.5480 0.509 0.09800 3.83e-04 9.82e-04 5.26e-01
Ribosomal scanning and start codon recognition 58 1.57e-27 5.22e-26 0.754 -0.0273 -0.467 -0.59100 7.19e-01 7.33e-10 6.72e-15
DNA strand elongation 32 1.84e-06 1.25e-05 0.753 -0.5270 -0.526 -0.11400 2.47e-07 2.55e-07 2.66e-01
Insulin receptor recycling 21 3.59e-05 1.70e-04 0.753 0.5680 0.463 -0.17300 6.68e-06 2.37e-04 1.70e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.33e-28 8.12e-27 0.748 -0.0102 -0.457 -0.59200 8.93e-01 1.24e-09 3.56e-15
ROS and RNS production in phagocytes 31 4.36e-08 4.00e-07 0.745 0.5980 0.416 -0.15600 8.18e-09 6.21e-05 1.33e-01
Josephin domain DUBs 10 1.92e-03 5.48e-03 0.744 0.4690 0.296 -0.49600 1.02e-02 1.05e-01 6.56e-03
Nucleobase biosynthesis 13 1.81e-03 5.21e-03 0.738 -0.3470 -0.565 -0.32500 3.01e-02 4.22e-04 4.26e-02
Signaling by Leptin 10 7.46e-03 1.75e-02 0.735 0.5640 0.400 -0.25000 2.00e-03 2.86e-02 1.72e-01
Pentose phosphate pathway 13 9.32e-04 2.93e-03 0.734 0.4870 0.398 -0.38000 2.39e-03 1.30e-02 1.78e-02
Activation of the pre-replicative complex 32 1.70e-06 1.17e-05 0.731 -0.4880 -0.544 -0.02500 1.77e-06 1.02e-07 8.06e-01
Formation of ATP by chemiosmotic coupling 18 2.53e-06 1.62e-05 0.730 0.4270 0.196 -0.55800 1.71e-03 1.50e-01 4.10e-05
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.90e-02 3.91e-02 0.728 0.4690 0.548 0.10200 7.12e-03 1.65e-03 5.57e-01
Dissolution of Fibrin Clot 12 7.63e-03 1.78e-02 0.728 0.5620 0.454 -0.08930 7.52e-04 6.50e-03 5.92e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 6.09e-06 3.52e-05 0.726 0.4750 0.409 -0.36600 1.13e-04 8.87e-04 2.99e-03
Generation of second messenger molecules 38 3.79e-07 3.07e-06 0.725 -0.4630 -0.499 -0.25200 7.92e-07 1.03e-07 7.20e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.09e-03 1.26e-02 0.722 0.5780 0.417 0.11300 5.27e-04 1.24e-02 4.96e-01
RHO GTPases activate IQGAPs 11 1.48e-02 3.18e-02 0.720 0.4290 0.562 0.13400 1.37e-02 1.25e-03 4.42e-01
EPHB-mediated forward signaling 32 6.65e-06 3.78e-05 0.719 0.4990 0.505 0.12000 1.05e-06 7.75e-07 2.42e-01
rRNA modification in the nucleus and cytosol 59 6.32e-12 9.55e-11 0.718 -0.3970 -0.537 -0.26300 1.37e-07 9.24e-13 4.65e-04
Budding and maturation of HIV virion 26 4.54e-06 2.74e-05 0.717 0.5260 0.428 -0.23400 3.49e-06 1.61e-04 3.89e-02
Hyaluronan metabolism 13 4.62e-03 1.15e-02 0.717 0.5110 0.466 -0.18800 1.41e-03 3.66e-03 2.40e-01
Processive synthesis on the lagging strand 15 4.11e-03 1.05e-02 0.716 -0.4330 -0.538 -0.19000 3.70e-03 3.08e-04 2.03e-01
Spry regulation of FGF signaling 16 3.22e-04 1.16e-03 0.713 0.4720 0.407 -0.34700 1.08e-03 4.79e-03 1.63e-02
Cargo concentration in the ER 30 1.40e-05 7.35e-05 0.711 0.5180 0.486 0.04780 9.21e-07 4.10e-06 6.50e-01
Signal transduction by L1 20 2.95e-04 1.07e-03 0.704 0.4360 0.552 0.03900 7.42e-04 1.91e-05 7.62e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 2.28e-04 8.66e-04 0.704 -0.4470 -0.494 -0.22700 1.52e-04 2.79e-05 5.38e-02
RHO GTPases activate PAKs 20 1.06e-03 3.27e-03 0.703 0.4830 0.504 0.08460 1.87e-04 9.54e-05 5.13e-01
Influenza Infection 154 8.11e-43 4.08e-41 0.703 -0.1840 -0.451 -0.50700 8.03e-05 4.42e-22 1.64e-27
Lagging Strand Synthesis 20 9.46e-04 2.94e-03 0.701 -0.4540 -0.520 -0.12600 4.37e-04 5.73e-05 3.30e-01
Diseases associated with the TLR signaling cascade 23 1.78e-04 7.01e-04 0.699 0.5350 0.449 -0.00317 8.91e-06 1.91e-04 9.79e-01
Diseases of Immune System 23 1.78e-04 7.01e-04 0.699 0.5350 0.449 -0.00317 8.91e-06 1.91e-04 9.79e-01
MAP2K and MAPK activation 34 1.31e-06 9.36e-06 0.695 0.5170 0.453 -0.10500 1.81e-07 4.82e-06 2.90e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 6.38e-06 3.66e-05 0.694 0.5190 0.436 -0.15000 1.29e-06 4.89e-05 1.61e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.66e-04 2.75e-03 0.690 -0.4220 -0.492 -0.23500 8.21e-04 9.36e-05 6.21e-02
Pre-NOTCH Processing in Golgi 18 1.12e-04 4.57e-04 0.688 0.4100 0.468 -0.29300 2.62e-03 5.80e-04 3.15e-02
Negative regulation of MET activity 18 1.65e-03 4.86e-03 0.686 0.5250 0.440 -0.03270 1.14e-04 1.23e-03 8.10e-01
Packaging Of Telomere Ends 20 2.49e-05 1.21e-04 0.686 0.4510 0.307 -0.41500 4.79e-04 1.73e-02 1.30e-03
Prolonged ERK activation events 13 1.33e-02 2.93e-02 0.684 0.4510 0.514 0.01800 4.89e-03 1.33e-03 9.10e-01
IRAK1 recruits IKK complex 10 3.88e-02 7.16e-02 0.683 0.5280 0.434 0.01060 3.83e-03 1.76e-02 9.53e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 3.88e-02 7.16e-02 0.683 0.5280 0.434 0.01060 3.83e-03 1.76e-02 9.53e-01
RHO GTPases activate PKNs 47 8.54e-09 8.67e-08 0.681 0.4810 0.468 -0.12100 1.18e-08 2.87e-08 1.52e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 8.43e-03 1.94e-02 0.679 0.5240 0.386 -0.19300 1.66e-03 2.06e-02 2.47e-01
Smooth Muscle Contraction 31 6.54e-06 3.74e-05 0.679 0.4930 0.447 -0.13700 2.03e-06 1.67e-05 1.88e-01
ERKs are inactivated 13 3.87e-03 9.98e-03 0.675 0.4300 0.443 -0.27400 7.27e-03 5.69e-03 8.69e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.t0_v_pod s.pod_crp s.t0_crp p.t0_v_pod p.pod_crp p.t0_crp
IRAK4 deficiency (TLR2/4) 10 7.84e-06 4.37e-05 1.2800 0.898000 8.76e-01 2.35e-01 8.77e-07 1.61e-06 1.98e-01
MyD88 deficiency (TLR2/4) 10 7.84e-06 4.37e-05 1.2800 0.898000 8.76e-01 2.35e-01 8.77e-07 1.61e-06 1.98e-01
Peptide chain elongation 88 2.05e-65 3.49e-63 1.1500 -0.285000 -7.05e-01 -8.62e-01 3.73e-06 2.46e-30 1.39e-44
Eukaryotic Translation Elongation 93 6.85e-69 2.33e-66 1.1400 -0.277000 -7.01e-01 -8.57e-01 3.91e-06 1.27e-31 1.65e-46
Viral mRNA Translation 88 1.89e-61 1.98e-59 1.1100 -0.266000 -6.79e-01 -8.33e-01 1.62e-05 3.14e-28 9.07e-42
Selenocysteine synthesis 92 2.28e-60 2.21e-58 1.1000 -0.303000 -6.85e-01 -8.06e-01 5.13e-07 5.82e-30 7.14e-41
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 12 1.99e-05 1.00e-04 1.1000 0.787000 7.65e-01 -5.51e-03 2.33e-06 4.40e-06 9.74e-01
alpha-linolenic acid (ALA) metabolism 12 1.99e-05 1.00e-04 1.1000 0.787000 7.65e-01 -5.51e-03 2.33e-06 4.40e-06 9.74e-01
Eukaryotic Translation Termination 92 4.92e-62 6.08e-60 1.0900 -0.268000 -6.69e-01 -8.22e-01 9.02e-06 1.18e-28 2.03e-42
Translocation of ZAP-70 to Immunological synapse 24 6.09e-10 6.84e-09 1.0900 -0.744000 -7.37e-01 -2.85e-01 2.80e-10 4.08e-10 1.56e-02
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 11 1.13e-06 8.28e-06 1.0800 0.678000 6.59e-01 -5.28e-01 9.92e-05 1.54e-04 2.43e-03
Formation of a pool of free 40S subunits 100 6.51e-71 2.95e-68 1.0700 -0.212000 -6.66e-01 -8.08e-01 2.53e-04 1.06e-30 1.81e-44
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 94 4.90e-58 3.92e-56 1.0400 -0.248000 -6.43e-01 -7.73e-01 3.28e-05 3.79e-27 1.53e-38
Regulation of TLR by endogenous ligand 11 3.18e-04 1.15e-03 1.0100 0.742000 6.77e-01 6.13e-02 2.04e-05 9.99e-05 7.25e-01
Uptake and function of anthrax toxins 10 1.73e-04 6.82e-04 0.9980 0.704000 6.41e-01 -3.01e-01 1.16e-04 4.50e-04 9.93e-02
Hyaluronan uptake and degradation 10 4.53e-04 1.59e-03 0.9960 0.727000 6.68e-01 -1.38e-01 6.91e-05 2.56e-04 4.49e-01
Response of EIF2AK4 (GCN2) to amino acid deficiency 100 1.77e-53 1.33e-51 0.9560 -0.225000 -6.03e-01 -7.07e-01 9.85e-05 1.85e-25 1.84e-34
L13a-mediated translational silencing of Ceruloplasmin expression 110 4.55e-67 1.24e-64 0.9540 -0.147000 -5.90e-01 -7.35e-01 7.91e-03 9.82e-27 1.13e-40
GTP hydrolysis and joining of the 60S ribosomal subunit 111 1.69e-65 3.28e-63 0.9410 -0.151000 -5.86e-01 -7.21e-01 6.10e-03 1.17e-26 1.85e-39
VLDLR internalisation and degradation 11 2.05e-06 1.35e-05 0.9380 0.467000 5.91e-01 -5.59e-01 7.35e-03 6.83e-04 1.33e-03
Advanced glycosylation endproduct receptor signaling 12 1.27e-04 5.12e-04 0.9180 0.650000 5.76e-01 -2.99e-01 9.67e-05 5.51e-04 7.30e-02
RNA Polymerase I Promoter Opening 19 3.80e-08 3.52e-07 0.9080 0.621000 4.61e-01 -4.77e-01 2.78e-06 5.07e-04 3.22e-04
Erythrocytes take up carbon dioxide and release oxygen 11 3.23e-04 1.16e-03 0.8990 0.720000 5.13e-01 -1.62e-01 3.54e-05 3.23e-03 3.53e-01
O2/CO2 exchange in erythrocytes 11 3.23e-04 1.16e-03 0.8990 0.720000 5.13e-01 -1.62e-01 3.54e-05 3.23e-03 3.53e-01
Cap-dependent Translation Initiation 118 2.14e-63 2.91e-61 0.8940 -0.135000 -5.53e-01 -6.90e-01 1.13e-02 3.07e-25 1.75e-38
Eukaryotic Translation Initiation 118 2.14e-63 2.91e-61 0.8940 -0.135000 -5.53e-01 -6.90e-01 1.13e-02 3.07e-25 1.75e-38
MET activates RAP1 and RAC1 10 4.50e-03 1.14e-02 0.8800 0.525000 6.34e-01 3.11e-01 4.06e-03 5.12e-04 8.87e-02
Selenoamino acid metabolism 114 3.53e-48 1.92e-46 0.8670 -0.232000 -5.60e-01 -6.20e-01 1.87e-05 4.62e-25 2.27e-30
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 114 1.41e-49 8.00e-48 0.8660 -0.199000 -5.33e-01 -6.53e-01 2.42e-04 8.00e-23 1.47e-33
Nonsense-Mediated Decay (NMD) 114 1.41e-49 8.00e-48 0.8660 -0.199000 -5.33e-01 -6.53e-01 2.42e-04 8.00e-23 1.47e-33
PD-1 signaling 28 2.25e-07 1.89e-06 0.8630 -0.578000 -5.92e-01 -2.46e-01 1.19e-07 5.91e-08 2.43e-02
Retrograde neurotrophin signalling 12 2.85e-04 1.05e-03 0.8560 0.566000 5.59e-01 -3.16e-01 6.82e-04 7.99e-04 5.78e-02
Formation of the ternary complex, and subsequently, the 43S complex 51 7.74e-29 2.77e-27 0.8550 -0.085600 -5.54e-01 -6.45e-01 2.90e-01 7.55e-12 1.50e-15
WNT5A-dependent internalization of FZD4 13 7.41e-06 4.18e-05 0.8480 0.448000 5.40e-01 -4.77e-01 5.16e-03 7.52e-04 2.93e-03
RHO GTPases Activate ROCKs 18 5.18e-05 2.32e-04 0.8480 0.539000 6.44e-01 1.13e-01 7.45e-05 2.20e-06 4.08e-01
Unwinding of DNA 12 1.67e-03 4.91e-03 0.8460 -0.647000 -5.36e-01 -9.35e-02 1.04e-04 1.29e-03 5.75e-01
SRP-dependent cotranslational protein targeting to membrane 111 1.84e-50 1.13e-48 0.8430 -0.137000 -5.04e-01 -6.62e-01 1.26e-02 4.08e-20 1.55e-33
Gap junction trafficking 13 2.38e-04 9.00e-04 0.8420 0.559000 5.67e-01 -2.72e-01 4.81e-04 3.97e-04 8.95e-02
RHO GTPases Activate WASPs and WAVEs 35 1.97e-09 2.07e-08 0.8390 0.606000 5.75e-01 -8.11e-02 5.50e-10 3.90e-09 4.07e-01
p130Cas linkage to MAPK signaling for integrins 11 1.70e-03 4.94e-03 0.8330 0.663000 4.90e-01 1.13e-01 1.39e-04 4.86e-03 5.15e-01
Influenza Viral RNA Transcription and Replication 135 6.97e-51 4.51e-49 0.8280 -0.228000 -5.29e-01 -5.95e-01 4.82e-06 2.38e-26 5.68e-33
NOTCH4 Activation and Transmission of Signal to the Nucleus 10 8.54e-03 1.96e-02 0.8200 0.521000 6.23e-01 1.10e-01 4.32e-03 6.41e-04 5.48e-01
Platelet sensitization by LDL 16 3.63e-04 1.30e-03 0.8140 0.551000 6.00e-01 4.36e-03 1.37e-04 3.25e-05 9.76e-01
Major pathway of rRNA processing in the nucleolus and cytosol 180 8.40e-59 7.14e-57 0.8080 -0.309000 -5.81e-01 -4.68e-01 8.81e-13 2.00e-41 1.92e-27
rRNA processing in the nucleus and cytosol 190 1.37e-61 1.55e-59 0.8080 -0.309000 -5.78e-01 -4.71e-01 1.87e-13 3.52e-43 3.59e-29
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 13 3.79e-03 9.83e-03 0.7920 0.554000 5.63e-01 6.16e-02 5.47e-04 4.38e-04 7.01e-01
Phosphorylation of CD3 and TCR zeta chains 27 4.43e-06 2.71e-05 0.7840 -0.541000 -5.14e-01 -2.40e-01 1.12e-06 3.72e-06 3.08e-02
DNA methylation 20 7.80e-07 6.01e-06 0.7840 0.521000 3.56e-01 -4.66e-01 5.45e-05 5.86e-03 3.12e-04
Neutrophil degranulation 458 2.96e-111 4.02e-108 0.7840 0.585000 5.07e-01 -1.25e-01 4.38e-103 8.68e-78 4.92e-06
Trafficking of GluR2-containing AMPA receptors 12 4.81e-04 1.67e-03 0.7800 0.471000 4.90e-01 -3.83e-01 4.70e-03 3.29e-03 2.15e-02
Detoxification of Reactive Oxygen Species 32 2.21e-08 2.10e-07 0.7790 0.560000 4.93e-01 -2.24e-01 4.23e-08 1.37e-06 2.83e-02
RHO GTPases Activate NADPH Oxidases 21 1.22e-05 6.47e-05 0.7750 0.557000 4.81e-01 -2.43e-01 9.74e-06 1.36e-04 5.44e-02
COPI-independent Golgi-to-ER retrograde traffic 33 2.83e-07 2.33e-06 0.7640 0.561000 5.18e-01 -3.41e-02 2.44e-08 2.55e-07 7.35e-01
Translation initiation complex formation 58 2.52e-28 8.56e-27 0.7580 -0.022200 -4.72e-01 -5.93e-01 7.70e-01 5.10e-10 5.29e-15
rRNA processing 217 2.99e-60 2.71e-58 0.7570 -0.291000 -5.29e-01 -4.56e-01 1.46e-13 2.54e-41 4.11e-31
Golgi Cisternae Pericentriolar Stack Reorganization 14 4.35e-03 1.11e-02 0.7540 0.548000 5.09e-01 9.80e-02 3.83e-04 9.82e-04 5.26e-01
Ribosomal scanning and start codon recognition 58 1.57e-27 5.22e-26 0.7540 -0.027300 -4.67e-01 -5.91e-01 7.19e-01 7.33e-10 6.72e-15
DNA strand elongation 32 1.84e-06 1.25e-05 0.7530 -0.527000 -5.26e-01 -1.14e-01 2.47e-07 2.55e-07 2.66e-01
Insulin receptor recycling 21 3.59e-05 1.70e-04 0.7530 0.568000 4.63e-01 -1.73e-01 6.68e-06 2.37e-04 1.70e-01
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 59 2.33e-28 8.12e-27 0.7480 -0.010200 -4.57e-01 -5.92e-01 8.93e-01 1.24e-09 3.56e-15
ROS and RNS production in phagocytes 31 4.36e-08 4.00e-07 0.7450 0.598000 4.16e-01 -1.56e-01 8.18e-09 6.21e-05 1.33e-01
Josephin domain DUBs 10 1.92e-03 5.48e-03 0.7440 0.469000 2.96e-01 -4.96e-01 1.02e-02 1.05e-01 6.56e-03
Nucleobase biosynthesis 13 1.81e-03 5.21e-03 0.7380 -0.347000 -5.65e-01 -3.25e-01 3.01e-02 4.22e-04 4.26e-02
Signaling by Leptin 10 7.46e-03 1.75e-02 0.7350 0.564000 4.00e-01 -2.50e-01 2.00e-03 2.86e-02 1.72e-01
Pentose phosphate pathway 13 9.32e-04 2.93e-03 0.7340 0.487000 3.98e-01 -3.80e-01 2.39e-03 1.30e-02 1.78e-02
Activation of the pre-replicative complex 32 1.70e-06 1.17e-05 0.7310 -0.488000 -5.44e-01 -2.50e-02 1.77e-06 1.02e-07 8.06e-01
Formation of ATP by chemiosmotic coupling 18 2.53e-06 1.62e-05 0.7300 0.427000 1.96e-01 -5.58e-01 1.71e-03 1.50e-01 4.10e-05
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 11 1.90e-02 3.91e-02 0.7280 0.469000 5.48e-01 1.02e-01 7.12e-03 1.65e-03 5.57e-01
Dissolution of Fibrin Clot 12 7.63e-03 1.78e-02 0.7280 0.562000 4.54e-01 -8.93e-02 7.52e-04 6.50e-03 5.92e-01
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 22 6.09e-06 3.52e-05 0.7260 0.475000 4.09e-01 -3.66e-01 1.13e-04 8.87e-04 2.99e-03
Generation of second messenger molecules 38 3.79e-07 3.07e-06 0.7250 -0.463000 -4.99e-01 -2.52e-01 7.92e-07 1.03e-07 7.20e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins 12 5.09e-03 1.26e-02 0.7220 0.578000 4.17e-01 1.13e-01 5.27e-04 1.24e-02 4.96e-01
RHO GTPases activate IQGAPs 11 1.48e-02 3.18e-02 0.7200 0.429000 5.62e-01 1.34e-01 1.37e-02 1.25e-03 4.42e-01
EPHB-mediated forward signaling 32 6.65e-06 3.78e-05 0.7190 0.499000 5.05e-01 1.20e-01 1.05e-06 7.75e-07 2.42e-01
rRNA modification in the nucleus and cytosol 59 6.32e-12 9.55e-11 0.7180 -0.397000 -5.37e-01 -2.63e-01 1.37e-07 9.24e-13 4.65e-04
Budding and maturation of HIV virion 26 4.54e-06 2.74e-05 0.7170 0.526000 4.28e-01 -2.34e-01 3.49e-06 1.61e-04 3.89e-02
Hyaluronan metabolism 13 4.62e-03 1.15e-02 0.7170 0.511000 4.66e-01 -1.88e-01 1.41e-03 3.66e-03 2.40e-01
Processive synthesis on the lagging strand 15 4.11e-03 1.05e-02 0.7160 -0.433000 -5.38e-01 -1.90e-01 3.70e-03 3.08e-04 2.03e-01
Spry regulation of FGF signaling 16 3.22e-04 1.16e-03 0.7130 0.472000 4.07e-01 -3.47e-01 1.08e-03 4.79e-03 1.63e-02
Cargo concentration in the ER 30 1.40e-05 7.35e-05 0.7110 0.518000 4.86e-01 4.78e-02 9.21e-07 4.10e-06 6.50e-01
Signal transduction by L1 20 2.95e-04 1.07e-03 0.7040 0.436000 5.52e-01 3.90e-02 7.42e-04 1.91e-05 7.62e-01
Resolution of AP sites via the multiple-nucleotide patch replacement pathway 24 2.28e-04 8.66e-04 0.7040 -0.447000 -4.94e-01 -2.27e-01 1.52e-04 2.79e-05 5.38e-02
RHO GTPases activate PAKs 20 1.06e-03 3.27e-03 0.7030 0.483000 5.04e-01 8.46e-02 1.87e-04 9.54e-05 5.13e-01
Influenza Infection 154 8.11e-43 4.08e-41 0.7030 -0.184000 -4.51e-01 -5.07e-01 8.03e-05 4.42e-22 1.64e-27
Lagging Strand Synthesis 20 9.46e-04 2.94e-03 0.7010 -0.454000 -5.20e-01 -1.26e-01 4.37e-04 5.73e-05 3.30e-01
Diseases associated with the TLR signaling cascade 23 1.78e-04 7.01e-04 0.6990 0.535000 4.49e-01 -3.17e-03 8.91e-06 1.91e-04 9.79e-01
Diseases of Immune System 23 1.78e-04 7.01e-04 0.6990 0.535000 4.49e-01 -3.17e-03 8.91e-06 1.91e-04 9.79e-01
MAP2K and MAPK activation 34 1.31e-06 9.36e-06 0.6950 0.517000 4.53e-01 -1.05e-01 1.81e-07 4.82e-06 2.90e-01
Endosomal Sorting Complex Required For Transport (ESCRT) 29 6.38e-06 3.66e-05 0.6940 0.519000 4.36e-01 -1.50e-01 1.29e-06 4.89e-05 1.61e-01
PCNA-Dependent Long Patch Base Excision Repair 21 8.66e-04 2.75e-03 0.6900 -0.422000 -4.92e-01 -2.35e-01 8.21e-04 9.36e-05 6.21e-02
Pre-NOTCH Processing in Golgi 18 1.12e-04 4.57e-04 0.6880 0.410000 4.68e-01 -2.93e-01 2.62e-03 5.80e-04 3.15e-02
Negative regulation of MET activity 18 1.65e-03 4.86e-03 0.6860 0.525000 4.40e-01 -3.27e-02 1.14e-04 1.23e-03 8.10e-01
Packaging Of Telomere Ends 20 2.49e-05 1.21e-04 0.6860 0.451000 3.07e-01 -4.15e-01 4.79e-04 1.73e-02 1.30e-03
Prolonged ERK activation events 13 1.33e-02 2.93e-02 0.6840 0.451000 5.14e-01 1.80e-02 4.89e-03 1.33e-03 9.10e-01
IRAK1 recruits IKK complex 10 3.88e-02 7.16e-02 0.6830 0.528000 4.34e-01 1.06e-02 3.83e-03 1.76e-02 9.53e-01
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 10 3.88e-02 7.16e-02 0.6830 0.528000 4.34e-01 1.06e-02 3.83e-03 1.76e-02 9.53e-01
RHO GTPases activate PKNs 47 8.54e-09 8.67e-08 0.6810 0.481000 4.68e-01 -1.21e-01 1.18e-08 2.87e-08 1.52e-01
InlB-mediated entry of Listeria monocytogenes into host cell 12 8.43e-03 1.94e-02 0.6790 0.524000 3.86e-01 -1.93e-01 1.66e-03 2.06e-02 2.47e-01
Smooth Muscle Contraction 31 6.54e-06 3.74e-05 0.6790 0.493000 4.47e-01 -1.37e-01 2.03e-06 1.67e-05 1.88e-01
ERKs are inactivated 13 3.87e-03 9.98e-03 0.6750 0.430000 4.43e-01 -2.74e-01 7.27e-03 5.69e-03 8.69e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 20 6.46e-04 2.14e-03 0.6730 0.510000 4.21e-01 -1.22e-01 7.84e-05 1.11e-03 3.44e-01
Neurodegenerative Diseases 20 6.46e-04 2.14e-03 0.6730 0.510000 4.21e-01 -1.22e-01 7.84e-05 1.11e-03 3.44e-01
Activation of ATR in response to replication stress 36 1.49e-06 1.06e-05 0.6710 -0.456000 -4.86e-01 7.86e-02 2.19e-06 4.50e-07 4.14e-01
Transferrin endocytosis and recycling 26 6.21e-05 2.70e-04 0.6710 0.508000 4.21e-01 -1.17e-01 7.19e-06 2.00e-04 3.01e-01
Removal of the Flap Intermediate 14 1.23e-02 2.73e-02 0.6670 -0.405000 -5.08e-01 -1.54e-01 8.77e-03 1.01e-03 3.19e-01
Signaling by high-kinase activity BRAF mutants 31 1.76e-05 9.08e-05 0.6660 0.498000 4.36e-01 -7.33e-02 1.58e-06 2.62e-05 4.80e-01
Erythropoietin activates RAS 13 1.86e-02 3.85e-02 0.6640 0.416000 5.06e-01 1.09e-01 9.35e-03 1.57e-03 4.97e-01
EGFR downregulation 27 4.13e-06 2.55e-05 0.6590 0.456000 3.37e-01 -3.36e-01 4.06e-05 2.41e-03 2.54e-03
Assembly Of The HIV Virion 15 7.73e-04 2.50e-03 0.6570 0.416000 2.86e-01 -4.20e-01 5.25e-03 5.52e-02 4.82e-03
RHO GTPases activate CIT 18 1.22e-03 3.69e-03 0.6560 0.366000 5.30e-01 1.28e-01 7.18e-03 1.00e-04 3.48e-01
Mucopolysaccharidoses 11 3.23e-02 6.10e-02 0.6540 0.448000 4.65e-01 -1.02e-01 1.02e-02 7.54e-03 5.57e-01
Telomere C-strand (Lagging Strand) Synthesis 34 2.79e-05 1.35e-04 0.6450 -0.387000 -4.64e-01 -2.25e-01 9.24e-05 2.76e-06 2.29e-02
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) 12 2.63e-02 5.15e-02 0.6440 0.478000 4.17e-01 -1.10e-01 4.11e-03 1.23e-02 5.08e-01
Diseases of hemostasis 12 2.63e-02 5.15e-02 0.6440 0.478000 4.17e-01 -1.10e-01 4.11e-03 1.23e-02 5.08e-01
AKT phosphorylates targets in the cytosol 14 6.31e-03 1.50e-02 0.6440 0.424000 4.33e-01 -2.17e-01 6.05e-03 5.00e-03 1.59e-01
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 11 3.17e-02 6.03e-02 0.6390 0.426000 4.59e-01 -1.28e-01 1.43e-02 8.44e-03 4.62e-01
Recycling pathway of L1 26 1.56e-04 6.19e-04 0.6380 0.422000 4.71e-01 -8.21e-02 1.92e-04 3.23e-05 4.69e-01
Regulation of IFNG signaling 14 2.49e-02 4.96e-02 0.6360 0.392000 4.42e-01 2.36e-01 1.10e-02 4.18e-03 1.27e-01
Membrane binding and targetting of GAG proteins 13 4.53e-03 1.14e-02 0.6350 0.445000 2.96e-01 -3.43e-01 5.47e-03 6.48e-02 3.23e-02
Synthesis And Processing Of GAG, GAGPOL Polyproteins 13 4.53e-03 1.14e-02 0.6350 0.445000 2.96e-01 -3.43e-01 5.47e-03 6.48e-02 3.23e-02
Glycogen synthesis 13 3.59e-03 9.42e-03 0.6310 0.404000 2.68e-01 -4.04e-01 1.16e-02 9.48e-02 1.17e-02
Gap junction trafficking and regulation 15 5.65e-03 1.38e-02 0.6290 0.407000 4.46e-01 -1.79e-01 6.31e-03 2.81e-03 2.31e-01
Sealing of the nuclear envelope (NE) by ESCRT-III 25 1.92e-04 7.44e-04 0.6280 0.431000 4.21e-01 -1.78e-01 1.89e-04 2.69e-04 1.23e-01
Sema4D in semaphorin signaling 22 5.25e-04 1.79e-03 0.6280 0.377000 5.02e-01 1.69e-02 2.19e-03 4.60e-05 8.91e-01
GAB1 signalosome 15 6.60e-03 1.56e-02 0.6280 0.456000 3.75e-01 -2.12e-01 2.22e-03 1.19e-02 1.54e-01
Platelet Aggregation (Plug Formation) 28 7.77e-05 3.34e-04 0.6280 0.487000 3.79e-01 -1.16e-01 8.31e-06 5.13e-04 2.90e-01
SUMOylation of immune response proteins 11 1.18e-02 2.63e-02 0.6270 0.409000 2.85e-01 -3.81e-01 1.89e-02 1.02e-01 2.87e-02
Amyloid fiber formation 51 4.18e-10 4.82e-09 0.6260 0.482000 3.22e-01 -2.38e-01 2.64e-09 6.92e-05 3.28e-03
Heme degradation 10 5.91e-02 1.02e-01 0.6260 0.395000 4.86e-01 3.80e-03 3.05e-02 7.80e-03 9.83e-01
Signaling by RAF1 mutants 34 2.95e-05 1.43e-04 0.6230 0.470000 4.05e-01 -5.52e-02 2.07e-06 4.41e-05 5.78e-01
Late endosomal microautophagy 30 5.23e-06 3.09e-05 0.6210 0.422000 3.23e-01 -3.21e-01 6.37e-05 2.17e-03 2.35e-03
SLBP independent Processing of Histone Pre-mRNAs 10 4.65e-03 1.16e-02 0.6190 -0.151000 -4.80e-01 -3.61e-01 4.08e-01 8.63e-03 4.81e-02
Regulation of expression of SLITs and ROBOs 159 3.71e-40 1.74e-38 0.6170 -0.044000 -3.11e-01 -5.31e-01 3.38e-01 1.38e-11 5.15e-31
Sema4D induced cell migration and growth-cone collapse 19 2.36e-03 6.52e-03 0.6140 0.374000 4.87e-01 -9.86e-06 4.76e-03 2.38e-04 1.00e+00
Suppression of phagosomal maturation 12 1.73e-02 3.63e-02 0.6140 0.436000 3.36e-01 -2.71e-01 8.84e-03 4.40e-02 1.04e-01
Integrin signaling 22 1.81e-03 5.21e-03 0.6120 0.469000 3.90e-01 -5.17e-02 1.41e-04 1.55e-03 6.75e-01
Purine ribonucleoside monophosphate biosynthesis 10 2.90e-02 5.60e-02 0.6110 -0.259000 -4.82e-01 -2.72e-01 1.57e-01 8.37e-03 1.36e-01
Common Pathway of Fibrin Clot Formation 14 8.95e-03 2.05e-02 0.6060 0.378000 4.32e-01 -1.95e-01 1.43e-02 5.16e-03 2.05e-01
Response of Mtb to phagocytosis 22 5.49e-04 1.86e-03 0.5990 0.458000 3.25e-01 -2.09e-01 1.99e-04 8.28e-03 9.03e-02
Telomere C-strand synthesis initiation 13 5.00e-02 8.84e-02 0.5980 -0.360000 -4.33e-01 -2.02e-01 2.48e-02 6.88e-03 2.07e-01
Resolution of Abasic Sites (AP sites) 37 4.33e-05 2.02e-04 0.5970 -0.349000 -3.86e-01 -2.94e-01 2.43e-04 4.90e-05 1.94e-03
Glycogen breakdown (glycogenolysis) 13 2.41e-02 4.82e-02 0.5960 0.416000 3.80e-01 -1.96e-01 9.48e-03 1.78e-02 2.22e-01
activated TAK1 mediates p38 MAPK activation 19 7.93e-03 1.84e-02 0.5940 0.453000 3.83e-01 -8.11e-03 6.23e-04 3.83e-03 9.51e-01
Response to elevated platelet cytosolic Ca2+ 108 4.21e-16 1.00e-14 0.5930 0.452000 3.61e-01 -1.35e-01 4.96e-16 9.34e-11 1.56e-02
Cleavage of the damaged purine 24 4.87e-05 2.21e-04 0.5930 0.356000 2.41e-01 -4.09e-01 2.52e-03 4.12e-02 5.27e-04
Depurination 24 4.87e-05 2.21e-04 0.5930 0.356000 2.41e-01 -4.09e-01 2.52e-03 4.12e-02 5.27e-04
Recognition and association of DNA glycosylase with site containing an affected purine 24 4.87e-05 2.21e-04 0.5930 0.356000 2.41e-01 -4.09e-01 2.52e-03 4.12e-02 5.27e-04
Signal regulatory protein family interactions 12 3.17e-02 6.03e-02 0.5920 0.411000 3.65e-01 -2.19e-01 1.37e-02 2.84e-02 1.90e-01
Platelet degranulation 104 2.03e-15 4.30e-14 0.5910 0.450000 3.58e-01 -1.36e-01 2.22e-15 2.79e-10 1.65e-02
Frs2-mediated activation 11 5.64e-02 9.82e-02 0.5890 0.376000 4.50e-01 -5.76e-02 3.06e-02 9.78e-03 7.41e-01
Signaling by Erythropoietin 24 1.07e-03 3.28e-03 0.5890 0.375000 4.53e-01 -3.09e-02 1.46e-03 1.20e-04 7.93e-01
SHC1 events in EGFR signaling 12 4.02e-02 7.38e-02 0.5860 0.473000 3.44e-01 -3.10e-02 4.53e-03 3.89e-02 8.52e-01
Pexophagy 11 6.14e-03 1.47e-02 0.5850 0.357000 1.18e-01 -4.47e-01 4.01e-02 4.98e-01 1.02e-02
FOXO-mediated transcription of cell death genes 16 2.54e-03 6.97e-03 0.5830 0.332000 2.99e-01 -3.76e-01 2.16e-02 3.87e-02 9.24e-03
Diseases of programmed cell death 22 1.69e-03 4.94e-03 0.5820 0.449000 3.42e-01 -1.41e-01 2.66e-04 5.53e-03 2.53e-01
GPVI-mediated activation cascade 31 8.86e-06 4.88e-05 0.5810 0.328000 4.71e-01 -8.85e-02 1.55e-03 5.61e-06 3.94e-01
Inhibition of DNA recombination at telomere 35 2.33e-07 1.93e-06 0.5810 0.344000 1.89e-01 -4.29e-01 4.31e-04 5.27e-02 1.14e-05
Notch-HLH transcription pathway 28 7.95e-05 3.38e-04 0.5810 0.409000 3.11e-01 -2.71e-01 1.79e-04 4.34e-03 1.32e-02
Collagen degradation 28 4.84e-04 1.68e-03 0.5810 0.415000 3.86e-01 -1.23e-01 1.41e-04 4.01e-04 2.60e-01
Regulated proteolysis of p75NTR 11 1.10e-01 1.68e-01 0.5800 0.412000 3.96e-01 9.97e-02 1.78e-02 2.29e-02 5.67e-01
Lysosome Vesicle Biogenesis 32 3.51e-05 1.68e-04 0.5800 0.403000 3.43e-01 -2.38e-01 7.95e-05 7.87e-04 1.98e-02
Platelet Adhesion to exposed collagen 13 1.12e-02 2.53e-02 0.5800 0.498000 2.97e-01 2.58e-03 1.88e-03 6.37e-02 9.87e-01
Scavenging by Class A Receptors 11 1.02e-01 1.58e-01 0.5740 0.368000 3.65e-01 2.47e-01 3.45e-02 3.62e-02 1.57e-01
EPH-Ephrin signaling 78 1.77e-10 2.21e-09 0.5730 0.405000 3.86e-01 -1.23e-01 6.30e-10 3.60e-09 6.12e-02
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16 1.08e-03 3.31e-03 0.5720 0.302000 1.22e-01 -4.70e-01 3.64e-02 3.97e-01 1.13e-03
Leading Strand Synthesis 14 5.11e-02 9.00e-02 0.5680 -0.367000 -4.28e-01 -6.73e-02 1.75e-02 5.50e-03 6.63e-01
Polymerase switching 14 5.11e-02 9.00e-02 0.5680 -0.367000 -4.28e-01 -6.73e-02 1.75e-02 5.50e-03 6.63e-01
Paradoxical activation of RAF signaling by kinase inactive BRAF 38 5.25e-05 2.32e-04 0.5670 0.431000 3.62e-01 -6.99e-02 4.26e-06 1.13e-04 4.56e-01
Signaling by RAS mutants 38 5.25e-05 2.32e-04 0.5670 0.431000 3.62e-01 -6.99e-02 4.26e-06 1.13e-04 4.56e-01
Signaling by moderate kinase activity BRAF mutants 38 5.25e-05 2.32e-04 0.5670 0.431000 3.62e-01 -6.99e-02 4.26e-06 1.13e-04 4.56e-01
Signaling downstream of RAS mutants 38 5.25e-05 2.32e-04 0.5670 0.431000 3.62e-01 -6.99e-02 4.26e-06 1.13e-04 4.56e-01
PKA activation in glucagon signalling 14 1.26e-02 2.78e-02 0.5650 0.344000 3.48e-01 -2.83e-01 2.60e-02 2.42e-02 6.64e-02
Signal amplification 28 1.07e-03 3.29e-03 0.5650 0.436000 3.58e-01 -1.08e-02 6.39e-05 1.03e-03 9.21e-01
GRB2 events in EGFR signaling 11 4.30e-02 7.83e-02 0.5630 0.470000 2.99e-01 -8.11e-02 6.93e-03 8.61e-02 6.41e-01
DARPP-32 events 22 4.51e-03 1.14e-02 0.5580 0.404000 3.64e-01 -1.26e-01 1.02e-03 3.14e-03 3.05e-01
Beta-catenin phosphorylation cascade 17 1.12e-02 2.53e-02 0.5580 0.365000 3.90e-01 -1.61e-01 9.15e-03 5.32e-03 2.50e-01
Class C/3 (Metabotropic glutamate/pheromone receptors) 11 2.02e-02 4.13e-02 0.5580 -0.276000 -1.94e-01 4.45e-01 1.13e-01 2.65e-01 1.06e-02
Infection with Mycobacterium tuberculosis 26 4.57e-04 1.60e-03 0.5580 0.447000 3.05e-01 -1.37e-01 7.89e-05 7.13e-03 2.28e-01
Pyrimidine salvage 10 6.17e-02 1.06e-01 0.5560 0.340000 3.67e-01 -2.42e-01 6.27e-02 4.43e-02 1.85e-01
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 11 2.36e-03 6.52e-03 0.5550 -0.081000 -4.37e-01 -3.32e-01 6.42e-01 1.21e-02 5.64e-02
MyD88:MAL(TIRAP) cascade initiated on plasma membrane 92 9.58e-13 1.56e-11 0.5540 0.437000 3.17e-01 -1.26e-01 4.28e-13 1.43e-07 3.71e-02
Toll Like Receptor 2 (TLR2) Cascade 92 9.58e-13 1.56e-11 0.5540 0.437000 3.17e-01 -1.26e-01 4.28e-13 1.43e-07 3.71e-02
Toll Like Receptor TLR1:TLR2 Cascade 92 9.58e-13 1.56e-11 0.5540 0.437000 3.17e-01 -1.26e-01 4.28e-13 1.43e-07 3.71e-02
Toll Like Receptor TLR6:TLR2 Cascade 92 9.58e-13 1.56e-11 0.5540 0.437000 3.17e-01 -1.26e-01 4.28e-13 1.43e-07 3.71e-02
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 22 7.42e-04 2.40e-03 0.5530 0.366000 2.55e-01 -3.26e-01 2.97e-03 3.84e-02 8.09e-03
G-protein beta:gamma signalling 29 9.66e-04 3.00e-03 0.5510 0.372000 4.02e-01 -6.47e-02 5.31e-04 1.81e-04 5.46e-01
Translesion synthesis by REV1 16 3.42e-02 6.42e-02 0.5510 -0.299000 -3.92e-01 -2.46e-01 3.86e-02 6.56e-03 8.90e-02
COPI-mediated anterograde transport 78 8.61e-09 8.67e-08 0.5500 0.390000 3.88e-01 -1.98e-02 2.65e-09 3.18e-09 7.63e-01
The NLRP3 inflammasome 15 2.06e-02 4.19e-02 0.5500 0.454000 3.10e-01 -1.72e-02 2.33e-03 3.78e-02 9.08e-01
Growth hormone receptor signaling 20 1.18e-02 2.64e-02 0.5490 0.417000 3.38e-01 1.16e-01 1.24e-03 8.78e-03 3.70e-01
HDACs deacetylate histones 47 1.18e-07 1.04e-06 0.5490 0.357000 2.65e-01 -3.22e-01 2.26e-05 1.66e-03 1.37e-04
Glycogen storage diseases 13 1.27e-02 2.81e-02 0.5480 0.302000 2.03e-01 -4.09e-01 5.91e-02 2.04e-01 1.06e-02
Interleukin-1 signaling 97 3.81e-13 6.81e-12 0.5460 0.429000 3.11e-01 -1.33e-01 2.63e-13 1.23e-07 2.40e-02
Translation 295 5.63e-67 1.28e-64 0.5460 -0.058700 -3.55e-01 -4.10e-01 8.28e-02 8.09e-26 6.86e-34
Transcriptional regulation of granulopoiesis 46 4.81e-06 2.88e-05 0.5450 0.423000 3.24e-01 -1.17e-01 6.97e-07 1.46e-04 1.69e-01
ERK/MAPK targets 22 3.16e-03 8.39e-03 0.5440 0.406000 3.11e-01 -1.85e-01 9.78e-04 1.16e-02 1.33e-01
Butyrophilin (BTN) family interactions 10 1.47e-01 2.11e-01 0.5440 -0.423000 -3.40e-01 -3.18e-02 2.06e-02 6.26e-02 8.62e-01
Apoptosis induced DNA fragmentation 10 1.80e-01 2.49e-01 0.5430 0.385000 3.58e-01 1.36e-01 3.51e-02 4.98e-02 4.56e-01
Pausing and recovery of Tat-mediated HIV elongation 30 5.13e-06 3.05e-05 0.5430 0.165000 6.64e-02 -5.13e-01 1.19e-01 5.29e-01 1.13e-06
Tat-mediated HIV elongation arrest and recovery 30 5.13e-06 3.05e-05 0.5430 0.165000 6.64e-02 -5.13e-01 1.19e-01 5.29e-01 1.13e-06
Polymerase switching on the C-strand of the telomere 26 4.07e-03 1.04e-02 0.5420 -0.305000 -3.85e-01 -2.30e-01 7.03e-03 6.83e-04 4.22e-02
Gastrin-CREB signalling pathway via PKC and MAPK 14 3.82e-02 7.09e-02 0.5420 0.407000 3.20e-01 -1.59e-01 8.37e-03 3.80e-02 3.04e-01
Synthesis of Leukotrienes (LT) and Eoxins (EX) 15 6.80e-03 1.60e-02 0.5390 0.280000 4.59e-01 -3.74e-02 6.07e-02 2.09e-03 8.02e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 15 1.49e-02 3.20e-02 0.5380 0.450000 2.78e-01 -9.62e-02 2.52e-03 6.20e-02 5.19e-01
ADP signalling through P2Y purinoceptor 1 21 1.47e-02 3.17e-02 0.5380 0.401000 3.58e-01 -1.40e-02 1.45e-03 4.51e-03 9.12e-01
COPII-mediated vesicle transport 65 6.62e-07 5.20e-06 0.5350 0.386000 3.70e-01 -9.03e-03 7.20e-08 2.55e-07 9.00e-01
Homologous DNA Pairing and Strand Exchange 42 2.61e-06 1.66e-05 0.5340 -0.357000 -2.72e-01 2.89e-01 6.21e-05 2.28e-03 1.19e-03
Glycogen metabolism 23 1.42e-03 4.22e-03 0.5330 0.360000 2.73e-01 -2.82e-01 2.79e-03 2.34e-02 1.93e-02
Extension of Telomeres 51 2.13e-05 1.06e-04 0.5320 -0.313000 -3.72e-01 -2.17e-01 1.09e-04 4.41e-06 7.38e-03
Interleukin-6 signaling 10 1.87e-01 2.56e-01 0.5290 0.398000 3.47e-01 2.84e-02 2.91e-02 5.72e-02 8.77e-01
LDL clearance 17 1.88e-02 3.88e-02 0.5260 0.343000 3.65e-01 -1.62e-01 1.44e-02 9.21e-03 2.48e-01
Signalling to ERKs 31 2.09e-03 5.88e-03 0.5260 0.395000 3.47e-01 1.84e-02 1.39e-04 8.34e-04 8.59e-01
HDR through MMEJ (alt-NHEJ) 10 1.13e-01 1.71e-01 0.5250 -0.430000 -2.94e-01 6.35e-02 1.84e-02 1.07e-01 7.28e-01
trans-Golgi Network Vesicle Budding 69 1.84e-07 1.57e-06 0.5250 0.370000 3.67e-01 -6.39e-02 1.06e-07 1.33e-07 3.59e-01
RAF activation 32 2.66e-03 7.23e-03 0.5240 0.363000 3.64e-01 1.02e-01 3.79e-04 3.60e-04 3.17e-01
Chondroitin sulfate biosynthesis 12 3.11e-02 5.96e-02 0.5240 0.292000 3.75e-01 -2.20e-01 7.95e-02 2.44e-02 1.86e-01
TBC/RABGAPs 45 2.87e-07 2.36e-06 0.5240 0.289000 3.21e-01 -2.96e-01 7.81e-04 1.93e-04 5.80e-04
Biotin transport and metabolism 11 6.31e-02 1.08e-01 0.5230 -0.444000 -2.76e-01 -2.86e-02 1.09e-02 1.13e-01 8.70e-01
Thrombin signalling through proteinase activated receptors (PARs) 27 2.09e-03 5.88e-03 0.5220 0.351000 3.62e-01 -1.33e-01 1.59e-03 1.11e-03 2.32e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 32 8.83e-06 4.88e-05 0.5210 0.245000 1.13e-01 -4.46e-01 1.64e-02 2.68e-01 1.27e-05
Antigen processing-Cross presentation 97 1.14e-10 1.47e-09 0.5200 0.400000 3.24e-01 -7.06e-02 9.20e-12 3.37e-08 2.30e-01
VxPx cargo-targeting to cilium 19 3.40e-02 6.40e-02 0.5200 0.324000 3.88e-01 1.24e-01 1.45e-02 3.45e-03 3.50e-01
tRNA modification in the nucleus and cytosol 43 8.29e-06 4.60e-05 0.5190 -0.269000 -4.29e-01 -1.12e-01 2.24e-03 1.10e-06 2.02e-01
Diseases of carbohydrate metabolism 29 2.49e-04 9.27e-04 0.5190 0.330000 2.63e-01 -3.02e-01 2.10e-03 1.42e-02 4.85e-03
ER to Golgi Anterograde Transport 129 1.02e-12 1.63e-11 0.5190 0.368000 3.66e-01 -8.93e-03 4.94e-13 7.33e-13 8.61e-01
Cellular response to hypoxia 71 2.96e-08 2.79e-07 0.5190 0.387000 3.17e-01 -1.38e-01 1.72e-08 3.85e-06 4.45e-02
Rev-mediated nuclear export of HIV RNA 35 7.04e-04 2.30e-03 0.5180 -0.337000 -3.94e-01 -5.03e-03 5.65e-04 5.54e-05 9.59e-01
ATF6 (ATF6-alpha) activates chaperone genes 10 7.34e-02 1.20e-01 0.5160 0.445000 2.61e-01 2.48e-02 1.49e-02 1.53e-01 8.92e-01
RAB geranylgeranylation 60 2.98e-06 1.89e-05 0.5160 0.367000 3.58e-01 -5.66e-02 8.81e-07 1.56e-06 4.48e-01
Presynaptic phase of homologous DNA pairing and strand exchange 39 1.34e-05 7.09e-05 0.5150 -0.331000 -2.62e-01 2.96e-01 3.45e-04 4.63e-03 1.40e-03
RHO GTPases activate KTN1 11 1.62e-01 2.30e-01 0.5150 0.394000 3.30e-01 3.55e-02 2.36e-02 5.82e-02 8.38e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 88 3.01e-11 4.30e-10 0.5140 0.413000 2.78e-01 -1.28e-01 2.05e-11 6.58e-06 3.77e-02
Energy dependent regulation of mTOR by LKB1-AMPK 27 4.57e-03 1.14e-02 0.5120 0.384000 3.30e-01 -7.58e-02 5.50e-04 2.98e-03 4.96e-01
Regulation of signaling by CBL 18 1.98e-03 5.62e-03 0.5120 0.258000 4.15e-01 -1.54e-01 5.84e-02 2.33e-03 2.59e-01
Cristae formation 31 3.25e-06 2.05e-05 0.5120 0.262000 4.06e-02 -4.37e-01 1.15e-02 6.95e-01 2.50e-05
Cytosolic iron-sulfur cluster assembly 13 4.68e-02 8.39e-02 0.5110 -0.194000 -2.20e-01 -4.19e-01 2.26e-01 1.70e-01 8.95e-03
Olfactory Signaling Pathway 57 1.72e-08 1.66e-07 0.5110 0.086100 1.73e-01 4.73e-01 2.61e-01 2.38e-02 6.44e-10
ADP signalling through P2Y purinoceptor 12 18 5.11e-02 9.00e-02 0.5100 0.373000 3.45e-01 4.33e-02 6.16e-03 1.13e-02 7.51e-01
Platelet activation, signaling and aggregation 219 3.39e-23 1.03e-21 0.5100 0.360000 3.41e-01 -1.15e-01 3.75e-20 2.89e-18 3.28e-03
RORA activates gene expression 18 1.71e-02 3.59e-02 0.5090 0.310000 3.98e-01 -7.15e-02 2.28e-02 3.49e-03 6.00e-01
Post-translational protein phosphorylation 69 1.29e-06 9.28e-06 0.5080 0.344000 3.73e-01 2.57e-02 7.83e-07 8.14e-08 7.12e-01
Toll Like Receptor 4 (TLR4) Cascade 121 2.58e-13 4.68e-12 0.5080 0.397000 3.03e-01 -9.19e-02 4.72e-14 8.30e-09 8.07e-02
HuR (ELAVL1) binds and stabilizes mRNA 10 1.33e-01 1.95e-01 0.5080 0.404000 2.82e-01 1.21e-01 2.68e-02 1.23e-01 5.07e-01
Interactions of Rev with host cellular proteins 37 5.65e-04 1.91e-03 0.5070 -0.329000 -3.86e-01 5.23e-03 5.27e-04 4.85e-05 9.56e-01
NF-kB is activated and signals survival 12 1.38e-02 3.01e-02 0.5070 0.264000 4.78e-02 -4.30e-01 1.13e-01 7.74e-01 9.86e-03
Synthesis of PIPs at the late endosome membrane 11 6.86e-02 1.14e-01 0.5070 0.201000 1.94e-01 4.23e-01 2.49e-01 2.64e-01 1.51e-02
HSP90 chaperone cycle for steroid hormone receptors (SHR) 36 1.60e-04 6.34e-04 0.5050 0.402000 2.78e-01 -1.27e-01 2.95e-05 3.88e-03 1.86e-01
Clathrin-mediated endocytosis 127 4.44e-13 7.85e-12 0.5050 0.357000 3.43e-01 -1.01e-01 3.55e-12 2.54e-11 5.00e-02
Cross-presentation of soluble exogenous antigens (endosomes) 47 1.86e-05 9.45e-05 0.5050 0.397000 2.93e-01 -1.07e-01 2.49e-06 5.04e-04 2.04e-01
Translation of Replicase and Assembly of the Replication Transcription Complex 12 1.42e-01 2.05e-01 0.5050 0.387000 3.23e-01 -6.33e-03 2.01e-02 5.25e-02 9.70e-01
Gap-filling DNA repair synthesis and ligation in GG-NER 25 5.16e-03 1.27e-02 0.5050 -0.225000 -3.46e-01 -2.90e-01 5.14e-02 2.73e-03 1.21e-02
MET activates RAS signaling 10 1.89e-01 2.58e-01 0.5040 0.355000 2.98e-01 1.99e-01 5.22e-02 1.03e-01 2.75e-01
Golgi Associated Vesicle Biogenesis 55 2.38e-05 1.16e-04 0.5030 0.367000 3.42e-01 -3.19e-02 2.53e-06 1.13e-05 6.83e-01
CD22 mediated BCR regulation 59 1.11e-17 2.79e-16 0.5020 -0.105000 -4.72e-01 -1.33e-01 1.62e-01 3.39e-10 7.75e-02
mTORC1-mediated signalling 23 2.30e-03 6.41e-03 0.5010 0.371000 2.32e-01 -2.44e-01 2.07e-03 5.36e-02 4.29e-02
MyD88 dependent cascade initiated on endosome 89 1.61e-10 2.03e-09 0.5010 0.401000 2.77e-01 -1.16e-01 6.21e-11 6.24e-06 5.78e-02
Toll Like Receptor 7/8 (TLR7/8) Cascade 89 1.61e-10 2.03e-09 0.5010 0.401000 2.77e-01 -1.16e-01 6.21e-11 6.24e-06 5.78e-02
Processive synthesis on the C-strand of the telomere 19 3.27e-02 6.18e-02 0.5010 -0.256000 -3.48e-01 -2.54e-01 5.36e-02 8.70e-03 5.56e-02
Activation of Matrix Metalloproteinases 22 4.92e-03 1.22e-02 0.5010 0.400000 2.60e-01 -1.51e-01 1.15e-03 3.50e-02 2.19e-01
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 53 2.78e-06 1.76e-05 0.5000 0.386000 2.78e-01 -1.54e-01 1.19e-06 4.59e-04 5.31e-02
G beta:gamma signalling through CDC42 17 7.58e-02 1.23e-01 0.4980 0.354000 3.37e-01 9.60e-02 1.15e-02 1.60e-02 4.93e-01
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 14 1.16e-01 1.74e-01 0.4980 -0.307000 -3.73e-01 -1.20e-01 4.70e-02 1.57e-02 4.36e-01
Regulation of ornithine decarboxylase (ODC) 49 1.00e-05 5.45e-05 0.4980 0.385000 2.80e-01 -1.45e-01 3.12e-06 6.98e-04 7.91e-02
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 21 1.27e-03 3.80e-03 0.4980 0.193000 9.72e-02 -4.48e-01 1.25e-01 4.41e-01 3.79e-04
BBSome-mediated cargo-targeting to cilium 22 1.84e-04 7.16e-04 0.4970 -0.193000 -4.50e-01 -8.43e-02 1.17e-01 2.56e-04 4.94e-01
MyD88 cascade initiated on plasma membrane 82 2.75e-10 3.25e-09 0.4960 0.394000 2.54e-01 -1.62e-01 6.99e-10 7.15e-05 1.12e-02
Toll Like Receptor 10 (TLR10) Cascade 82 2.75e-10 3.25e-09 0.4960 0.394000 2.54e-01 -1.62e-01 6.99e-10 7.15e-05 1.12e-02
Toll Like Receptor 5 (TLR5) Cascade 82 2.75e-10 3.25e-09 0.4960 0.394000 2.54e-01 -1.62e-01 6.99e-10 7.15e-05 1.12e-02
Antimicrobial peptides 33 4.12e-07 3.28e-06 0.4950 0.460000 1.79e-01 -3.68e-02 4.69e-06 7.44e-02 7.14e-01
Translesion synthesis by POLI 17 4.99e-02 8.83e-02 0.4950 -0.265000 -3.74e-01 -1.88e-01 5.83e-02 7.61e-03 1.81e-01
Plasma lipoprotein clearance 28 4.51e-04 1.59e-03 0.4950 0.281000 2.78e-01 -2.99e-01 1.01e-02 1.10e-02 6.22e-03
Signaling by BRAF and RAF fusions 57 9.39e-06 5.13e-05 0.4950 0.389000 3.06e-01 -1.16e-02 3.76e-07 6.46e-05 8.80e-01
NEP/NS2 Interacts with the Cellular Export Machinery 32 1.68e-03 4.92e-03 0.4940 -0.323000 -3.68e-01 6.47e-02 1.54e-03 3.12e-04 5.26e-01
Pre-NOTCH Expression and Processing 65 4.05e-07 3.24e-06 0.4940 0.350000 3.07e-01 -1.67e-01 1.09e-06 1.86e-05 2.01e-02
Vpr-mediated nuclear import of PICs 34 1.00e-03 3.10e-03 0.4930 -0.311000 -3.82e-01 2.59e-02 1.70e-03 1.15e-04 7.94e-01
HDMs demethylate histones 22 6.23e-04 2.09e-03 0.4930 0.244000 4.05e-01 -1.39e-01 4.76e-02 9.96e-04 2.58e-01
Fanconi Anemia Pathway 36 2.33e-03 6.45e-03 0.4930 -0.357000 -3.38e-01 -3.02e-02 2.12e-04 4.41e-04 7.54e-01
Formation of apoptosome 11 1.84e-01 2.53e-01 0.4900 0.383000 3.07e-01 6.57e-03 2.80e-02 7.83e-02 9.70e-01
Regulation of the apoptosome activity 11 1.84e-01 2.53e-01 0.4900 0.383000 3.07e-01 6.57e-03 2.80e-02 7.83e-02 9.70e-01
Mitochondrial translation elongation 91 8.89e-17 2.16e-15 0.4900 -0.015200 -2.75e-01 -4.05e-01 8.02e-01 5.59e-06 2.45e-11
Complex I biogenesis 55 3.35e-09 3.48e-08 0.4900 0.249000 7.34e-02 -4.15e-01 1.41e-03 3.46e-01 9.94e-08
Metabolism of non-coding RNA 53 9.06e-07 6.84e-06 0.4890 -0.258000 -4.13e-01 -5.22e-02 1.18e-03 1.97e-07 5.11e-01
snRNP Assembly 53 9.06e-07 6.84e-06 0.4890 -0.258000 -4.13e-01 -5.22e-02 1.18e-03 1.97e-07 5.11e-01
EPHA-mediated growth cone collapse 13 1.18e-01 1.77e-01 0.4890 0.281000 3.84e-01 1.11e-01 7.91e-02 1.65e-02 4.86e-01
Signaling by ROBO receptors 199 1.06e-31 4.01e-30 0.4880 -0.012500 -2.18e-01 -4.37e-01 7.61e-01 1.13e-07 2.06e-26
MAP3K8 (TPL2)-dependent MAPK1/3 activation 16 1.44e-02 3.13e-02 0.4880 0.364000 1.97e-01 -2.58e-01 1.16e-02 1.72e-01 7.39e-02
Pre-NOTCH Transcription and Translation 49 3.22e-05 1.54e-04 0.4870 0.355000 2.98e-01 -1.50e-01 1.72e-05 3.13e-04 6.95e-02
Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.44e-05 7.48e-05 0.4860 0.376000 2.64e-01 -1.60e-01 6.57e-06 1.54e-03 5.54e-02
Signaling by MET 61 1.82e-05 9.35e-05 0.4860 0.365000 3.21e-01 1.28e-02 8.34e-07 1.48e-05 8.63e-01
Base-Excision Repair, AP Site Formation 31 1.13e-04 4.59e-04 0.4850 0.255000 1.54e-01 -3.82e-01 1.39e-02 1.37e-01 2.30e-04
Cell-extracellular matrix interactions 14 6.98e-02 1.16e-01 0.4850 0.366000 2.72e-01 -1.64e-01 1.78e-02 7.75e-02 2.89e-01
Cleavage of the damaged pyrimidine 29 2.78e-04 1.03e-03 0.4840 0.277000 1.70e-01 -3.58e-01 9.75e-03 1.13e-01 8.33e-04
Depyrimidination 29 2.78e-04 1.03e-03 0.4840 0.277000 1.70e-01 -3.58e-01 9.75e-03 1.13e-01 8.33e-04
Recognition and association of DNA glycosylase with site containing an affected pyrimidine 29 2.78e-04 1.03e-03 0.4840 0.277000 1.70e-01 -3.58e-01 9.75e-03 1.13e-01 8.33e-04
Defective CFTR causes cystic fibrosis 59 1.73e-06 1.19e-05 0.4840 0.365000 2.73e-01 -1.63e-01 1.27e-06 2.80e-04 3.05e-02
Disassembly of the destruction complex and recruitment of AXIN to the membrane 29 6.72e-04 2.21e-03 0.4830 0.304000 2.29e-01 -2.98e-01 4.65e-03 3.25e-02 5.47e-03
Interactions of Vpr with host cellular proteins 37 5.34e-04 1.82e-03 0.4830 -0.287000 -3.88e-01 -2.56e-02 2.53e-03 4.43e-05 7.88e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 64 1.16e-06 8.42e-06 0.4830 0.366000 2.86e-01 -1.33e-01 4.11e-07 7.65e-05 6.62e-02
GP1b-IX-V activation signalling 10 1.51e-01 2.17e-01 0.4820 0.353000 2.55e-01 -2.07e-01 5.34e-02 1.62e-01 2.58e-01
Signaling by NTRK1 (TRKA) 100 3.84e-10 4.46e-09 0.4810 0.365000 2.87e-01 -1.29e-01 2.86e-10 7.35e-07 2.58e-02
Regulation of TP53 Activity through Acetylation 29 4.55e-04 1.60e-03 0.4810 -0.202000 -1.71e-01 -4.02e-01 5.98e-02 1.12e-01 1.78e-04
Senescence-Associated Secretory Phenotype (SASP) 66 6.79e-09 7.00e-08 0.4810 0.300000 1.90e-01 -3.24e-01 2.52e-05 7.60e-03 5.29e-06
Calnexin/calreticulin cycle 26 6.11e-03 1.46e-02 0.4800 0.361000 2.81e-01 -1.46e-01 1.43e-03 1.30e-02 1.99e-01
Toll-like Receptor Cascades 143 5.09e-14 9.75e-13 0.4800 0.381000 2.87e-01 -6.07e-02 3.65e-15 3.27e-09 2.10e-01
Innate Immune System 966 5.49e-90 3.73e-87 0.4800 0.369000 2.93e-01 -9.02e-02 1.30e-84 6.75e-54 2.06e-06
ATF6 (ATF6-alpha) activates chaperones 12 6.52e-02 1.10e-01 0.4800 0.414000 2.42e-01 1.28e-02 1.30e-02 1.47e-01 9.39e-01
Signaling by NTRKs 115 2.57e-11 3.72e-10 0.4800 0.361000 2.91e-01 -1.21e-01 2.14e-11 6.81e-08 2.53e-02
Cytochrome c-mediated apoptotic response 13 1.65e-01 2.33e-01 0.4790 0.339000 3.06e-01 1.45e-01 3.43e-02 5.63e-02 3.65e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 124 4.03e-20 1.07e-18 0.4790 0.262000 7.41e-02 -3.94e-01 4.70e-07 1.54e-01 3.46e-14
Nuclear import of Rev protein 34 2.24e-03 6.28e-03 0.4780 -0.308000 -3.65e-01 1.57e-02 1.87e-03 2.32e-04 8.74e-01
Diseases of DNA repair 10 2.44e-01 3.17e-01 0.4770 -0.367000 -2.94e-01 -7.96e-02 4.43e-02 1.07e-01 6.63e-01
Cargo recognition for clathrin-mediated endocytosis 90 1.05e-08 1.04e-07 0.4770 0.332000 3.18e-01 -1.25e-01 4.97e-08 1.76e-07 4.04e-02
AUF1 (hnRNP D0) binds and destabilizes mRNA 53 1.69e-06 1.17e-05 0.4770 0.365000 2.30e-01 -2.03e-01 4.36e-06 3.80e-03 1.04e-02
Toll Like Receptor 9 (TLR9) Cascade 93 4.45e-10 5.09e-09 0.4770 0.387000 2.62e-01 -9.56e-02 1.14e-10 1.30e-05 1.11e-01
Hh mutants abrogate ligand secretion 54 6.32e-06 3.64e-05 0.4760 0.365000 2.61e-01 -1.58e-01 3.38e-06 9.07e-04 4.43e-02
Regulation of localization of FOXO transcription factors 11 7.09e-02 1.17e-01 0.4760 0.239000 2.07e-01 -3.55e-01 1.69e-01 2.33e-01 4.16e-02
ER-Phagosome pathway 82 7.52e-08 6.86e-07 0.4760 0.364000 2.91e-01 -9.41e-02 1.16e-08 5.32e-06 1.41e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs 82 8.80e-09 8.80e-08 0.4740 0.357000 2.60e-01 -1.71e-01 2.22e-08 4.76e-05 7.39e-03
Degradation of DVL 54 4.46e-06 2.71e-05 0.4730 0.359000 2.49e-01 -1.82e-01 5.07e-06 1.57e-03 2.04e-02
Abortive elongation of HIV-1 transcript in the absence of Tat 23 1.15e-03 3.49e-03 0.4730 0.153000 3.27e-02 -4.46e-01 2.04e-01 7.86e-01 2.13e-04
Negative regulation of FGFR3 signaling 20 1.63e-02 3.45e-02 0.4720 0.332000 2.49e-01 -2.25e-01 1.02e-02 5.42e-02 8.16e-02
RNA Polymerase III Chain Elongation 18 4.06e-02 7.44e-02 0.4720 -0.189000 -2.80e-01 -3.29e-01 1.65e-01 3.97e-02 1.56e-02
Respiratory electron transport 101 5.13e-16 1.18e-14 0.4720 0.264000 7.54e-02 -3.83e-01 4.35e-06 1.90e-01 2.84e-11
CD28 dependent PI3K/Akt signaling 22 4.55e-03 1.14e-02 0.4700 -0.297000 -2.01e-01 -3.04e-01 1.58e-02 1.02e-01 1.36e-02
Thromboxane signalling through TP receptor 20 2.70e-02 5.26e-02 0.4700 0.369000 2.71e-01 -1.08e-01 4.28e-03 3.60e-02 4.04e-01
G beta:gamma signalling through PLC beta 17 6.61e-02 1.11e-01 0.4700 0.336000 3.09e-01 -1.12e-01 1.66e-02 2.74e-02 4.25e-01
Alpha-protein kinase 1 signaling pathway 11 1.12e-02 2.53e-02 0.4690 0.434000 1.32e-01 -1.20e-01 1.27e-02 4.47e-01 4.90e-01
Inflammasomes 20 6.43e-03 1.53e-02 0.4670 0.399000 2.25e-01 9.06e-02 1.99e-03 8.09e-02 4.83e-01
HIV elongation arrest and recovery 32 8.55e-05 3.60e-04 0.4670 0.156000 7.58e-02 -4.34e-01 1.28e-01 4.58e-01 2.14e-05
Pausing and recovery of HIV elongation 32 8.55e-05 3.60e-04 0.4670 0.156000 7.58e-02 -4.34e-01 1.28e-01 4.58e-01 2.14e-05
Hedgehog ligand biogenesis 58 1.01e-05 5.47e-05 0.4670 0.355000 2.74e-01 -1.30e-01 3.00e-06 3.00e-04 8.64e-02
Glucagon signaling in metabolic regulation 27 1.07e-02 2.43e-02 0.4670 0.329000 3.13e-01 -1.05e-01 3.04e-03 4.82e-03 3.47e-01
Vif-mediated degradation of APOBEC3G 52 1.34e-05 7.09e-05 0.4660 0.357000 2.49e-01 -1.66e-01 8.64e-06 1.85e-03 3.86e-02
RNA Polymerase I Transcription Initiation 47 7.81e-05 3.34e-04 0.4660 -0.208000 -3.44e-01 -2.35e-01 1.38e-02 4.45e-05 5.31e-03
Mitochondrial tRNA aminoacylation 21 6.07e-02 1.05e-01 0.4650 -0.309000 -3.35e-01 -9.31e-02 1.42e-02 7.84e-03 4.60e-01
Regulation of TP53 Activity through Association with Co-factors 11 1.03e-01 1.59e-01 0.4650 -0.077800 -1.76e-01 -4.23e-01 6.55e-01 3.11e-01 1.50e-02
RAB GEFs exchange GTP for GDP on RABs 87 2.16e-07 1.84e-06 0.4650 0.315000 3.41e-01 -3.19e-02 3.86e-07 3.84e-08 6.07e-01
Translocation of SLC2A4 (GLUT4) to the plasma membrane 48 6.63e-04 2.19e-03 0.4650 0.337000 3.10e-01 8.07e-02 5.34e-05 2.03e-04 3.34e-01
Interleukin-1 family signaling 124 3.43e-11 4.80e-10 0.4630 0.358000 2.81e-01 -8.49e-02 5.58e-12 6.29e-08 1.02e-01
Golgi-to-ER retrograde transport 111 8.46e-09 8.65e-08 0.4630 0.329000 3.25e-01 -1.28e-02 2.06e-09 3.25e-09 8.16e-01
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 31 6.05e-03 1.45e-02 0.4620 -0.310000 -3.38e-01 5.88e-02 2.78e-03 1.14e-03 5.71e-01
Regulation of Glucokinase by Glucokinase Regulatory Protein 31 6.05e-03 1.45e-02 0.4620 -0.310000 -3.38e-01 5.88e-02 2.78e-03 1.14e-03 5.71e-01
Gluconeogenesis 28 7.88e-04 2.53e-03 0.4620 0.240000 2.54e-01 -3.01e-01 2.77e-02 1.99e-02 5.76e-03
Synthesis of active ubiquitin: roles of E1 and E2 enzymes 30 2.43e-04 9.12e-04 0.4610 0.389000 1.91e-01 -1.57e-01 2.24e-04 7.06e-02 1.36e-01
Synthesis of PC 23 4.33e-02 7.87e-02 0.4610 0.320000 3.02e-01 1.37e-01 7.80e-03 1.23e-02 2.54e-01
PCP/CE pathway 86 2.51e-09 2.63e-08 0.4600 0.305000 2.45e-01 -2.43e-01 9.84e-07 8.77e-05 9.91e-05
Beta-oxidation of very long chain fatty acids 10 2.12e-01 2.83e-01 0.4600 0.275000 3.68e-01 -1.66e-02 1.32e-01 4.38e-02 9.27e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter 28 1.25e-02 2.78e-02 0.4600 -0.263000 -2.74e-01 -2.59e-01 1.62e-02 1.20e-02 1.77e-02
The role of Nef in HIV-1 replication and disease pathogenesis 28 7.82e-04 2.52e-03 0.4590 0.228000 1.75e-01 -3.58e-01 3.65e-02 1.09e-01 1.04e-03
Negative regulation of NOTCH4 signaling 54 1.74e-05 8.98e-05 0.4580 0.351000 2.52e-01 -1.52e-01 8.10e-06 1.37e-03 5.36e-02
G beta:gamma signalling through PI3Kgamma 22 1.62e-02 3.45e-02 0.4570 0.282000 3.39e-01 -1.20e-01 2.19e-02 5.89e-03 3.31e-01
tRNA processing in the nucleus 59 5.18e-05 2.32e-04 0.4570 -0.290000 -3.52e-01 -2.43e-02 1.16e-04 2.82e-06 7.47e-01
Iron uptake and transport 52 1.83e-05 9.36e-05 0.4570 0.374000 2.45e-01 -9.28e-02 3.06e-06 2.20e-03 2.47e-01
Amino acids regulate mTORC1 50 4.83e-05 2.21e-04 0.4570 0.316000 2.69e-01 -1.90e-01 1.13e-04 9.81e-04 1.98e-02
Nucleotide salvage 21 2.32e-02 4.66e-02 0.4560 0.314000 2.70e-01 -1.92e-01 1.27e-02 3.23e-02 1.29e-01
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 79 4.44e-06 2.71e-05 0.4550 0.307000 3.35e-01 2.98e-02 2.38e-06 2.62e-07 6.47e-01
Response of EIF2AK1 (HRI) to heme deficiency 14 3.23e-02 6.10e-02 0.4550 0.366000 2.02e-01 1.79e-01 1.77e-02 1.91e-01 2.46e-01
Caspase activation via extrinsic apoptotic signalling pathway 25 3.92e-02 7.23e-02 0.4550 0.302000 3.13e-01 1.32e-01 9.00e-03 6.70e-03 2.52e-01
Folding of actin by CCT/TriC 10 5.74e-03 1.39e-02 0.4540 0.129000 -2.43e-01 -3.61e-01 4.79e-01 1.84e-01 4.78e-02
PKA activation 15 4.69e-02 8.39e-02 0.4540 0.265000 2.36e-01 -2.83e-01 7.59e-02 1.13e-01 5.76e-02
G beta:gamma signalling through BTK 15 1.66e-01 2.34e-01 0.4540 0.317000 3.23e-01 4.08e-02 3.38e-02 3.04e-02 7.84e-01
MTOR signalling 38 6.62e-04 2.19e-03 0.4530 0.352000 2.48e-01 -1.40e-01 1.70e-04 8.28e-03 1.36e-01
Translesion synthesis by POLK 17 9.33e-02 1.47e-01 0.4530 -0.245000 -3.38e-01 -1.74e-01 8.00e-02 1.57e-02 2.15e-01
Postmitotic nuclear pore complex (NPC) reformation 27 8.28e-03 1.91e-02 0.4520 -0.265000 -3.66e-01 -1.14e-02 1.73e-02 9.81e-04 9.19e-01
MAP kinase activation 63 1.51e-06 1.07e-05 0.4520 0.365000 2.37e-01 -1.23e-01 5.50e-07 1.14e-03 9.14e-02
Mitochondrial translation initiation 91 9.67e-15 1.93e-13 0.4520 -0.010100 -2.59e-01 -3.70e-01 8.67e-01 1.99e-05 9.97e-10
Signaling by EGFR 46 8.60e-05 3.61e-04 0.4510 0.329000 2.36e-01 -1.97e-01 1.13e-04 5.52e-03 2.05e-02
Negative regulation of FGFR4 signaling 21 1.36e-02 2.99e-02 0.4500 0.309000 2.08e-01 -2.53e-01 1.41e-02 9.94e-02 4.46e-02
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 26 8.99e-04 2.83e-03 0.4500 -0.247000 -9.22e-02 3.65e-01 2.95e-02 4.16e-01 1.26e-03
Activation of the AP-1 family of transcription factors 10 8.82e-02 1.40e-01 0.4490 0.394000 1.82e-01 -1.16e-01 3.11e-02 3.20e-01 5.24e-01
NS1 Mediated Effects on Host Pathways 40 8.34e-04 2.66e-03 0.4490 -0.308000 -2.88e-01 1.53e-01 7.52e-04 1.62e-03 9.34e-02
Mitochondrial translation termination 91 2.13e-14 4.19e-13 0.4490 -0.015900 -2.61e-01 -3.64e-01 7.93e-01 1.66e-05 1.84e-09
Signaling by NOTCH4 78 9.35e-07 6.99e-06 0.4480 0.336000 2.75e-01 -1.12e-01 2.93e-07 2.61e-05 8.81e-02
Degradation of GLI2 by the proteasome 56 1.04e-05 5.58e-05 0.4470 0.348000 2.33e-01 -1.57e-01 6.66e-06 2.60e-03 4.20e-02
Regulation of PTEN stability and activity 66 1.07e-05 5.70e-05 0.4470 0.340000 2.73e-01 -9.91e-02 1.82e-06 1.24e-04 1.64e-01
N-glycan trimming in the ER and Calnexin/Calreticulin cycle 35 9.36e-04 2.93e-03 0.4470 0.312000 2.30e-01 -2.23e-01 1.41e-03 1.86e-02 2.27e-02
Activated NOTCH1 Transmits Signal to the Nucleus 27 3.92e-03 1.01e-02 0.4470 0.265000 2.88e-01 -2.15e-01 1.72e-02 9.58e-03 5.27e-02
IKK complex recruitment mediated by RIP1 23 3.01e-02 5.80e-02 0.4470 0.356000 2.66e-01 4.11e-02 3.11e-03 2.70e-02 7.33e-01
Transport to the Golgi and subsequent modification 155 5.05e-12 7.72e-11 0.4460 0.310000 3.16e-01 -5.51e-02 2.58e-11 1.14e-11 2.37e-01
Activation of G protein gated Potassium channels 19 9.72e-02 1.53e-01 0.4460 0.320000 2.91e-01 1.08e-01 1.58e-02 2.80e-02 4.15e-01
G protein gated Potassium channels 19 9.72e-02 1.53e-01 0.4460 0.320000 2.91e-01 1.08e-01 1.58e-02 2.80e-02 4.15e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 19 9.72e-02 1.53e-01 0.4460 0.320000 2.91e-01 1.08e-01 1.58e-02 2.80e-02 4.15e-01
Formation of Fibrin Clot (Clotting Cascade) 26 1.66e-02 3.50e-02 0.4450 0.309000 2.95e-01 -1.26e-01 6.46e-03 9.15e-03 2.67e-01
mRNA decay by 3' to 5' exoribonuclease 16 1.02e-01 1.59e-01 0.4450 -0.238000 -3.47e-01 -1.45e-01 9.93e-02 1.63e-02 3.15e-01
Regulation of Apoptosis 51 4.66e-05 2.14e-04 0.4450 0.355000 2.39e-01 -1.20e-01 1.12e-05 3.20e-03 1.38e-01
Transport of Ribonucleoproteins into the Host Nucleus 32 5.28e-03 1.30e-02 0.4440 -0.289000 -3.25e-01 8.78e-02 4.60e-03 1.45e-03 3.90e-01
Oncogenic MAPK signaling 73 2.12e-05 1.05e-04 0.4430 0.332000 2.90e-01 3.66e-02 9.20e-07 1.78e-05 5.89e-01
Export of Viral Ribonucleoproteins from Nucleus 33 6.09e-03 1.46e-02 0.4420 -0.287000 -3.33e-01 4.39e-02 4.31e-03 9.25e-04 6.62e-01
EPH-ephrin mediated repulsion of cells 39 1.98e-04 7.64e-04 0.4420 0.253000 2.67e-01 -2.44e-01 6.21e-03 3.89e-03 8.24e-03
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 5.43e-05 2.38e-04 0.4420 0.349000 2.41e-01 -1.24e-01 1.34e-05 2.63e-03 1.23e-01
Misspliced GSK3beta mutants stabilize beta-catenin 15 1.13e-01 1.71e-01 0.4410 0.287000 3.21e-01 -9.60e-02 5.41e-02 3.12e-02 5.20e-01
S33 mutants of beta-catenin aren't phosphorylated 15 1.13e-01 1.71e-01 0.4410 0.287000 3.21e-01 -9.60e-02 5.41e-02 3.12e-02 5.20e-01
S37 mutants of beta-catenin aren't phosphorylated 15 1.13e-01 1.71e-01 0.4410 0.287000 3.21e-01 -9.60e-02 5.41e-02 3.12e-02 5.20e-01
S45 mutants of beta-catenin aren't phosphorylated 15 1.13e-01 1.71e-01 0.4410 0.287000 3.21e-01 -9.60e-02 5.41e-02 3.12e-02 5.20e-01
T41 mutants of beta-catenin aren't phosphorylated 15 1.13e-01 1.71e-01 0.4410 0.287000 3.21e-01 -9.60e-02 5.41e-02 3.12e-02 5.20e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 15 1.13e-01 1.71e-01 0.4410 0.287000 3.21e-01 -9.60e-02 5.41e-02 3.12e-02 5.20e-01
Condensation of Prometaphase Chromosomes 11 1.47e-01 2.11e-01 0.4410 0.091900 2.05e-01 3.80e-01 5.98e-01 2.40e-01 2.92e-02
Post-chaperonin tubulin folding pathway 19 4.74e-02 8.46e-02 0.4410 0.279000 3.22e-01 -1.12e-01 3.53e-02 1.51e-02 3.97e-01
Removal of the Flap Intermediate from the C-strand 17 1.03e-01 1.59e-01 0.4400 -0.219000 -3.06e-01 -2.29e-01 1.19e-01 2.88e-02 1.03e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 14 1.98e-01 2.69e-01 0.4400 -0.253000 -3.18e-01 -1.66e-01 1.01e-01 3.92e-02 2.81e-01
Interleukin-3, Interleukin-5 and GM-CSF signaling 40 8.84e-05 3.70e-04 0.4390 0.236000 3.61e-01 -8.38e-02 9.77e-03 7.78e-05 3.59e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 4.47e-05 2.07e-04 0.4390 0.343000 2.23e-01 -1.58e-01 2.64e-05 6.29e-03 5.25e-02
p53-Independent DNA Damage Response 50 4.47e-05 2.07e-04 0.4390 0.343000 2.23e-01 -1.58e-01 2.64e-05 6.29e-03 5.25e-02
p53-Independent G1/S DNA damage checkpoint 50 4.47e-05 2.07e-04 0.4390 0.343000 2.23e-01 -1.58e-01 2.64e-05 6.29e-03 5.25e-02
Degradation of GLI1 by the proteasome 57 2.08e-05 1.04e-04 0.4390 0.343000 2.38e-01 -1.36e-01 7.51e-06 1.92e-03 7.50e-02
Acyl chain remodelling of PI 10 2.32e-01 3.05e-01 0.4390 0.364000 2.41e-01 -4.46e-02 4.64e-02 1.87e-01 8.07e-01
Vpu mediated degradation of CD4 50 2.14e-05 1.06e-04 0.4390 0.340000 2.05e-01 -1.86e-01 3.18e-05 1.20e-02 2.30e-02
Condensation of Prophase Chromosomes 29 3.38e-03 8.92e-03 0.4380 0.306000 2.08e-01 -2.34e-01 4.39e-03 5.21e-02 2.89e-02
Signaling by NOTCH 182 4.61e-16 1.08e-14 0.4380 0.317000 2.51e-01 -1.68e-01 1.59e-13 5.18e-09 9.45e-05
RNA Polymerase III Transcription Initiation From Type 2 Promoter 27 2.12e-02 4.30e-02 0.4370 -0.251000 -2.53e-01 -2.52e-01 2.37e-02 2.26e-02 2.31e-02
Ubiquitin-dependent degradation of Cyclin D 50 5.44e-05 2.38e-04 0.4360 0.330000 2.21e-01 -1.80e-01 5.30e-05 6.75e-03 2.80e-02
XBP1(S) activates chaperone genes 47 1.11e-04 4.55e-04 0.4360 0.276000 2.62e-01 -2.13e-01 1.05e-03 1.91e-03 1.14e-02
Formation of the cornified envelope 21 1.53e-02 3.28e-02 0.4360 0.374000 2.15e-01 -5.96e-02 3.00e-03 8.77e-02 6.36e-01
Intraflagellar transport 39 5.84e-03 1.41e-02 0.4350 -0.256000 -3.11e-01 -1.65e-01 5.58e-03 7.86e-04 7.38e-02
G-protein activation 23 6.33e-02 1.08e-01 0.4350 0.321000 2.92e-01 3.71e-02 7.70e-03 1.54e-02 7.58e-01
tRNA processing 134 1.81e-09 1.92e-08 0.4350 -0.255000 -3.22e-01 -1.43e-01 3.46e-07 1.20e-10 4.24e-03
Interferon alpha/beta signaling 57 1.77e-11 2.62e-10 0.4350 -0.287000 8.89e-03 3.27e-01 1.80e-04 9.08e-01 1.96e-05
Nuclear Events (kinase and transcription factor activation) 53 6.21e-05 2.70e-04 0.4340 0.317000 2.39e-01 -1.76e-01 6.38e-05 2.60e-03 2.70e-02
TRAF6-mediated induction of TAK1 complex within TLR4 complex 16 4.73e-02 8.45e-02 0.4340 0.362000 2.06e-01 -1.24e-01 1.22e-02 1.54e-01 3.91e-01
Adenylate cyclase inhibitory pathway 11 7.74e-02 1.26e-01 0.4340 0.211000 3.38e-01 -1.71e-01 2.25e-01 5.22e-02 3.25e-01
L1CAM interactions 84 6.08e-06 3.52e-05 0.4340 0.302000 3.12e-01 -3.63e-03 1.74e-06 7.88e-07 9.54e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling 22 4.07e-03 1.04e-02 0.4330 0.301000 1.20e-01 -2.88e-01 1.46e-02 3.31e-01 1.95e-02
Membrane Trafficking 557 1.62e-39 7.35e-38 0.4330 0.308000 3.00e-01 -5.41e-02 1.65e-35 9.98e-34 2.89e-02
Transport of the SLBP independent Mature mRNA 35 3.09e-03 8.24e-03 0.4320 -0.272000 -3.24e-01 8.83e-02 5.31e-03 9.17e-04 3.66e-01
TAK1 activates NFkB by phosphorylation and activation of IKKs complex 27 6.70e-03 1.58e-02 0.4320 0.335000 2.12e-01 -1.69e-01 2.56e-03 5.60e-02 1.28e-01
MAPK targets/ Nuclear events mediated by MAP kinases 31 3.40e-03 8.94e-03 0.4310 0.349000 2.21e-01 -1.24e-01 7.83e-04 3.29e-02 2.32e-01
Surfactant metabolism 21 6.64e-02 1.12e-01 0.4310 0.301000 3.02e-01 -6.63e-02 1.71e-02 1.67e-02 5.99e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus 23 1.56e-02 3.34e-02 0.4300 0.260000 2.70e-01 -2.11e-01 3.10e-02 2.49e-02 7.92e-02
GLI3 is processed to GLI3R by the proteasome 57 1.41e-05 7.35e-05 0.4300 0.331000 2.15e-01 -1.72e-01 1.54e-05 4.96e-03 2.51e-02
MyD88-independent TLR4 cascade 96 3.79e-08 3.52e-07 0.4300 0.338000 2.44e-01 -1.04e-01 9.93e-09 3.54e-05 7.76e-02
TRIF(TICAM1)-mediated TLR4 signaling 96 3.79e-08 3.52e-07 0.4300 0.338000 2.44e-01 -1.04e-01 9.93e-09 3.54e-05 7.76e-02
HDR through Single Strand Annealing (SSA) 37 8.99e-04 2.83e-03 0.4300 -0.281000 -2.22e-01 2.39e-01 3.14e-03 1.96e-02 1.19e-02
Tryptophan catabolism 12 1.57e-01 2.23e-01 0.4290 0.219000 1.92e-01 3.16e-01 1.90e-01 2.50e-01 5.81e-02
Mitochondrial translation 97 4.46e-15 9.19e-14 0.4290 -0.001450 -2.53e-01 -3.46e-01 9.80e-01 1.64e-05 3.72e-09
IRE1alpha activates chaperones 49 7.88e-05 3.36e-04 0.4290 0.266000 2.51e-01 -2.24e-01 1.28e-03 2.40e-03 6.59e-03
Triglyceride catabolism 16 1.70e-01 2.38e-01 0.4290 0.317000 2.89e-01 -2.71e-03 2.82e-02 4.56e-02 9.85e-01
Classical antibody-mediated complement activation 69 1.73e-15 3.73e-14 0.4290 -0.102000 -4.12e-01 -6.21e-02 1.43e-01 3.30e-09 3.73e-01
HSF1-dependent transactivation 29 8.11e-04 2.60e-03 0.4290 0.122000 2.43e-03 -4.11e-01 2.54e-01 9.82e-01 1.29e-04
NIK-->noncanonical NF-kB signaling 57 6.86e-06 3.88e-05 0.4280 0.338000 2.00e-01 -1.71e-01 1.03e-05 8.87e-03 2.55e-02
Signaling by PDGFRA extracellular domain mutants 12 1.82e-01 2.52e-01 0.4270 0.285000 2.20e-01 2.30e-01 8.77e-02 1.88e-01 1.67e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 12 1.82e-01 2.52e-01 0.4270 0.285000 2.20e-01 2.30e-01 8.77e-02 1.88e-01 1.67e-01
Signaling by cytosolic FGFR1 fusion mutants 18 9.82e-02 1.54e-01 0.4270 0.239000 2.43e-01 2.58e-01 7.92e-02 7.46e-02 5.86e-02
ABC transporter disorders 70 1.78e-06 1.22e-05 0.4260 0.317000 2.19e-01 -1.81e-01 4.44e-06 1.50e-03 8.81e-03
Negative regulation of FGFR1 signaling 24 3.33e-02 6.26e-02 0.4260 0.298000 2.75e-01 -1.29e-01 1.16e-02 1.95e-02 2.75e-01
Mismatch Repair 15 1.83e-01 2.52e-01 0.4250 -0.242000 -3.20e-01 -1.40e-01 1.05e-01 3.16e-02 3.49e-01
tRNA processing in the mitochondrion 30 1.80e-04 7.05e-04 0.4250 -0.145000 -6.18e-02 -3.95e-01 1.69e-01 5.58e-01 1.82e-04
Dectin-1 mediated noncanonical NF-kB signaling 58 6.06e-06 3.52e-05 0.4240 0.331000 1.95e-01 -1.80e-01 1.29e-05 1.03e-02 1.74e-02
Activation of BAD and translocation to mitochondria 15 1.32e-01 1.94e-01 0.4230 0.309000 2.50e-01 -1.46e-01 3.85e-02 9.36e-02 3.27e-01
Presynaptic function of Kainate receptors 18 8.43e-02 1.35e-01 0.4230 0.304000 2.57e-01 -1.43e-01 2.53e-02 5.93e-02 2.94e-01
Endogenous sterols 16 1.56e-01 2.23e-01 0.4220 0.317000 2.72e-01 -5.90e-02 2.82e-02 5.97e-02 6.83e-01
Disorders of developmental biology 12 8.93e-02 1.41e-01 0.4210 0.181000 1.79e-01 -3.36e-01 2.78e-01 2.84e-01 4.38e-02
Loss of function of MECP2 in Rett syndrome 12 8.93e-02 1.41e-01 0.4210 0.181000 1.79e-01 -3.36e-01 2.78e-01 2.84e-01 4.38e-02
Pervasive developmental disorders 12 8.93e-02 1.41e-01 0.4210 0.181000 1.79e-01 -3.36e-01 2.78e-01 2.84e-01 4.38e-02
Aquaporin-mediated transport 37 5.62e-03 1.37e-02 0.4210 0.311000 2.68e-01 -9.64e-02 1.07e-03 4.84e-03 3.10e-01
Degradation of cysteine and homocysteine 12 8.57e-02 1.37e-01 0.4210 0.153000 1.28e-01 -3.70e-01 3.58e-01 4.41e-01 2.65e-02
E3 ubiquitin ligases ubiquitinate target proteins 52 3.19e-05 1.53e-04 0.4210 0.324000 1.94e-01 -1.86e-01 5.43e-05 1.57e-02 2.02e-02
Interleukin-17 signaling 68 3.94e-06 2.45e-05 0.4200 0.335000 2.19e-01 -1.28e-01 1.79e-06 1.77e-03 6.69e-02
RMTs methylate histone arginines 37 2.07e-04 7.93e-04 0.4190 0.006940 -4.33e-02 -4.17e-01 9.42e-01 6.48e-01 1.13e-05
Metabolism of Angiotensinogen to Angiotensins 11 1.18e-01 1.77e-01 0.4190 0.352000 1.71e-01 -1.50e-01 4.31e-02 3.27e-01 3.89e-01
rRNA processing in the mitochondrion 27 1.08e-02 2.44e-02 0.4190 -0.157000 -1.77e-01 -3.45e-01 1.58e-01 1.11e-01 1.90e-03
ER Quality Control Compartment (ERQC) 21 4.68e-02 8.39e-02 0.4180 0.329000 2.31e-01 -1.14e-01 9.13e-03 6.63e-02 3.64e-01
MET promotes cell motility 26 6.18e-02 1.06e-01 0.4180 0.292000 2.87e-01 8.50e-02 1.00e-02 1.14e-02 4.53e-01
Rab regulation of trafficking 120 1.26e-09 1.39e-08 0.4180 0.269000 2.98e-01 -1.15e-01 3.70e-07 1.61e-08 2.89e-02
Attenuation phase 23 3.83e-03 9.91e-03 0.4170 0.209000 4.42e-02 -3.59e-01 8.22e-02 7.14e-01 2.92e-03
Repression of WNT target genes 14 7.37e-02 1.21e-01 0.4170 -0.125000 -1.13e-01 -3.82e-01 4.20e-01 4.63e-01 1.34e-02
Activation of GABAB receptors 30 2.86e-02 5.53e-02 0.4170 0.280000 3.09e-01 5.54e-03 7.92e-03 3.44e-03 9.58e-01
GABA B receptor activation 30 2.86e-02 5.53e-02 0.4170 0.280000 3.09e-01 5.54e-03 7.92e-03 3.44e-03 9.58e-01
Autodegradation of the E3 ubiquitin ligase COP1 49 1.45e-04 5.81e-04 0.4160 0.315000 2.06e-01 -1.77e-01 1.37e-04 1.28e-02 3.20e-02
Uptake and actions of bacterial toxins 27 1.37e-02 3.01e-02 0.4150 0.309000 2.18e-01 -1.72e-01 5.48e-03 5.00e-02 1.22e-01
Metabolism of amine-derived hormones 10 1.24e-01 1.84e-01 0.4150 -0.193000 -2.87e-01 2.29e-01 2.89e-01 1.16e-01 2.10e-01
Plasma lipoprotein assembly, remodeling, and clearance 52 8.04e-05 3.40e-04 0.4150 0.250000 2.79e-01 -1.78e-01 1.80e-03 4.97e-04 2.66e-02
Interleukin-2 signaling 11 6.33e-02 1.08e-01 0.4150 0.038700 8.99e-02 -4.03e-01 8.24e-01 6.06e-01 2.07e-02
VEGFA-VEGFR2 Pathway 90 1.44e-06 1.02e-05 0.4140 0.293000 2.73e-01 -1.06e-01 1.48e-06 7.76e-06 8.27e-02
Signaling by EGFR in Cancer 23 8.77e-03 2.01e-02 0.4140 0.341000 1.70e-01 -1.61e-01 4.60e-03 1.58e-01 1.83e-01
Metabolism of porphyrins 22 7.81e-02 1.27e-01 0.4130 0.306000 2.71e-01 -5.71e-02 1.29e-02 2.76e-02 6.43e-01
Integration of energy metabolism 86 2.25e-06 1.45e-05 0.4120 0.288000 2.70e-01 -1.18e-01 3.81e-06 1.45e-05 5.84e-02
Creation of C4 and C2 activators 71 2.50e-15 5.23e-14 0.4120 -0.090300 -3.97e-01 -6.10e-02 1.88e-01 7.26e-09 3.74e-01
The role of GTSE1 in G2/M progression after G2 checkpoint 58 5.94e-05 2.60e-04 0.4110 0.329000 2.19e-01 -1.11e-01 1.43e-05 3.86e-03 1.44e-01
Cell recruitment (pro-inflammatory response) 22 1.15e-02 2.59e-02 0.4110 0.362000 1.92e-01 3.20e-02 3.32e-03 1.20e-01 7.95e-01
Purinergic signaling in leishmaniasis infection 22 1.15e-02 2.59e-02 0.4110 0.362000 1.92e-01 3.20e-02 3.32e-03 1.20e-01 7.95e-01
Downregulation of ERBB2:ERBB3 signaling 12 6.44e-02 1.09e-01 0.4100 0.152000 -3.40e-02 -3.79e-01 3.61e-01 8.39e-01 2.29e-02
mRNA Splicing - Minor Pathway 52 8.49e-07 6.49e-06 0.4100 0.043500 -1.58e-01 -3.76e-01 5.87e-01 4.87e-02 2.73e-06
Transport of the SLBP Dependant Mature mRNA 36 3.34e-03 8.86e-03 0.4090 -0.247000 -3.15e-01 8.47e-02 1.02e-02 1.07e-03 3.79e-01
Regulation of RUNX3 expression and activity 55 1.82e-04 7.11e-04 0.4090 0.304000 2.31e-01 -1.47e-01 9.37e-05 3.10e-03 5.85e-02
GABA receptor activation 35 1.79e-02 3.74e-02 0.4090 0.266000 3.08e-01 4.27e-02 6.50e-03 1.59e-03 6.62e-01
Interleukin-27 signaling 11 3.06e-01 3.78e-01 0.4090 0.278000 2.32e-01 1.90e-01 1.10e-01 1.83e-01 2.75e-01
SIRT1 negatively regulates rRNA expression 24 7.81e-03 1.82e-02 0.4090 0.283000 1.36e-01 -2.62e-01 1.64e-02 2.49e-01 2.63e-02
Metabolism of polyamines 57 4.11e-05 1.94e-04 0.4090 0.329000 2.06e-01 -1.28e-01 1.72e-05 7.22e-03 9.51e-02
Opioid Signalling 75 2.21e-05 1.09e-04 0.4070 0.287000 2.68e-01 -1.07e-01 1.69e-05 5.96e-05 1.08e-01
Protein ubiquitination 72 7.82e-07 6.01e-06 0.4070 0.318000 1.84e-01 -1.76e-01 3.12e-06 6.93e-03 9.67e-03
Diseases associated with glycosylation precursor biosynthesis 18 1.26e-01 1.87e-01 0.4070 0.292000 2.66e-01 -9.66e-02 3.18e-02 5.04e-02 4.78e-01
Regulation of FZD by ubiquitination 15 3.14e-02 6.00e-02 0.4070 -0.011700 -2.27e-01 -3.38e-01 9.37e-01 1.28e-01 2.35e-02
Mitochondrial protein import 64 1.58e-09 1.71e-08 0.4070 0.032000 -2.16e-01 -3.44e-01 6.58e-01 2.84e-03 1.99e-06
Regulation of cholesterol biosynthesis by SREBP (SREBF) 55 2.86e-04 1.05e-03 0.4070 0.245000 3.25e-01 -6.40e-03 1.69e-03 3.08e-05 9.35e-01
Scavenging of heme from plasma 71 6.15e-18 1.61e-16 0.4070 -0.039200 -3.90e-01 -1.09e-01 5.68e-01 1.33e-08 1.14e-01
PPARA activates gene expression 104 1.67e-07 1.45e-06 0.4060 0.265000 2.98e-01 -7.69e-02 2.95e-06 1.46e-07 1.75e-01
Autophagy 124 2.03e-10 2.46e-09 0.4060 0.309000 2.06e-01 -1.66e-01 2.93e-09 7.57e-05 1.40e-03
ERBB2 Regulates Cell Motility 10 1.86e-01 2.55e-01 0.4060 0.313000 1.56e-01 -2.06e-01 8.67e-02 3.94e-01 2.59e-01
Constitutive Signaling by AKT1 E17K in Cancer 25 5.20e-03 1.28e-02 0.4050 0.182000 2.13e-01 -2.92e-01 1.15e-01 6.49e-02 1.16e-02
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12 2.50e-01 3.23e-01 0.4030 0.268000 2.15e-01 2.11e-01 1.08e-01 1.96e-01 2.07e-01
PINK1-PRKN Mediated Mitophagy 21 7.33e-05 3.16e-04 0.4020 0.183000 -1.56e-01 -3.23e-01 1.46e-01 2.17e-01 1.05e-02
Acetylcholine Neurotransmitter Release Cycle 11 2.30e-01 3.03e-01 0.4020 -0.104000 -1.73e-01 -3.48e-01 5.49e-01 3.21e-01 4.57e-02
Formation of the beta-catenin:TCF transactivating complex 46 1.31e-04 5.27e-04 0.4020 0.221000 1.50e-01 -3.00e-01 9.39e-03 7.86e-02 4.35e-04
Plasma lipoprotein assembly 10 2.48e-01 3.21e-01 0.4020 0.231000 2.87e-01 -1.59e-01 2.05e-01 1.16e-01 3.83e-01
Semaphorin interactions 57 2.54e-04 9.44e-04 0.4010 0.252000 3.04e-01 -6.67e-02 1.01e-03 6.98e-05 3.84e-01
FCGR activation 76 9.63e-13 1.56e-11 0.4000 -0.115000 -3.76e-01 -7.30e-02 8.32e-02 1.37e-08 2.71e-01
tRNA Aminoacylation 42 2.32e-03 6.45e-03 0.4000 -0.244000 -3.14e-01 4.71e-02 6.32e-03 4.34e-04 5.97e-01
Activation of NF-kappaB in B cells 65 1.86e-05 9.45e-05 0.4000 0.305000 2.01e-01 -1.61e-01 2.04e-05 5.04e-03 2.44e-02
TGF-beta receptor signaling activates SMADs 32 4.27e-03 1.09e-02 0.3990 0.272000 1.74e-01 -2.36e-01 7.84e-03 8.86e-02 2.10e-02
NOTCH1 Intracellular Domain Regulates Transcription 44 6.54e-05 2.83e-04 0.3990 0.302000 1.33e-01 -2.25e-01 5.36e-04 1.28e-01 9.67e-03
ABC transporters in lipid homeostasis 14 2.97e-01 3.70e-01 0.3990 -0.255000 -2.65e-01 -1.54e-01 9.87e-02 8.57e-02 3.19e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 29 5.01e-04 1.72e-03 0.3990 0.316000 9.73e-02 -2.23e-01 3.26e-03 3.64e-01 3.76e-02
Metabolism of steroid hormones 19 1.39e-01 2.01e-01 0.3980 0.310000 2.49e-01 5.69e-03 1.91e-02 5.97e-02 9.66e-01
A tetrasaccharide linker sequence is required for GAG synthesis 17 1.07e-01 1.65e-01 0.3980 -0.160000 -1.83e-01 -3.15e-01 2.52e-01 1.92e-01 2.44e-02
Vasopressin regulates renal water homeostasis via Aquaporins 34 1.58e-02 3.37e-02 0.3980 0.288000 2.56e-01 -9.69e-02 3.63e-03 9.69e-03 3.28e-01
AMER1 mutants destabilize the destruction complex 14 2.01e-01 2.71e-01 0.3970 0.257000 2.86e-01 -1.00e-01 9.64e-02 6.35e-02 5.15e-01
APC truncation mutants have impaired AXIN binding 14 2.01e-01 2.71e-01 0.3970 0.257000 2.86e-01 -1.00e-01 9.64e-02 6.35e-02 5.15e-01
AXIN missense mutants destabilize the destruction complex 14 2.01e-01 2.71e-01 0.3970 0.257000 2.86e-01 -1.00e-01 9.64e-02 6.35e-02 5.15e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling 14 2.01e-01 2.71e-01 0.3970 0.257000 2.86e-01 -1.00e-01 9.64e-02 6.35e-02 5.15e-01
Truncations of AMER1 destabilize the destruction complex 14 2.01e-01 2.71e-01 0.3970 0.257000 2.86e-01 -1.00e-01 9.64e-02 6.35e-02 5.15e-01
truncated APC mutants destabilize the destruction complex 14 2.01e-01 2.71e-01 0.3970 0.257000 2.86e-01 -1.00e-01 9.64e-02 6.35e-02 5.15e-01
Signaling by NOTCH1 66 2.22e-05 1.09e-04 0.3970 0.286000 2.04e-01 -1.84e-01 5.74e-05 4.24e-03 9.54e-03
BMAL1:CLOCK,NPAS2 activates circadian gene expression 25 1.47e-02 3.18e-02 0.3960 0.204000 3.40e-01 1.23e-02 7.79e-02 3.29e-03 9.15e-01
Biosynthesis of specialized proresolving mediators (SPMs) 16 1.36e-01 1.98e-01 0.3950 0.291000 2.17e-01 -1.57e-01 4.37e-02 1.34e-01 2.77e-01
SUMOylation of DNA methylation proteins 16 7.40e-02 1.21e-01 0.3950 -0.036600 -1.61e-01 -3.58e-01 8.00e-01 2.63e-01 1.31e-02
Platelet homeostasis 69 2.36e-04 8.94e-04 0.3940 0.279000 2.74e-01 -5.07e-02 6.22e-05 8.09e-05 4.66e-01
p75NTR signals via NF-kB 15 2.47e-02 4.93e-02 0.3940 0.291000 6.82e-02 -2.57e-01 5.12e-02 6.48e-01 8.42e-02
Glycosphingolipid metabolism 36 4.56e-03 1.14e-02 0.3930 0.236000 2.96e-01 -1.06e-01 1.41e-02 2.12e-03 2.71e-01
Activation of gene expression by SREBF (SREBP) 42 1.77e-03 5.11e-03 0.3930 0.235000 3.03e-01 -8.62e-02 8.36e-03 6.78e-04 3.34e-01
Rap1 signalling 13 2.14e-01 2.85e-01 0.3920 0.325000 2.16e-01 3.54e-02 4.22e-02 1.77e-01 8.25e-01
CLEC7A (Dectin-1) signaling 96 9.53e-08 8.64e-07 0.3920 0.308000 1.95e-01 -1.44e-01 1.84e-07 9.85e-04 1.50e-02
PLC beta mediated events 43 2.88e-03 7.79e-03 0.3900 0.271000 2.34e-01 -1.55e-01 2.13e-03 7.83e-03 7.82e-02
Glutamate and glutamine metabolism 12 1.10e-01 1.68e-01 0.3900 -0.094900 -2.97e-01 -2.34e-01 5.69e-01 7.48e-02 1.61e-01
Interleukin-10 signaling 34 2.04e-02 4.16e-02 0.3890 0.293000 2.45e-01 -7.50e-02 3.07e-03 1.35e-02 4.49e-01
Citric acid cycle (TCA cycle) 22 8.05e-02 1.30e-01 0.3890 0.266000 2.58e-01 -1.18e-01 3.10e-02 3.59e-02 3.39e-01
Incretin synthesis, secretion, and inactivation 10 1.31e-01 1.92e-01 0.3880 0.167000 7.24e-02 3.43e-01 3.61e-01 6.92e-01 6.05e-02
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 10 1.31e-01 1.92e-01 0.3880 0.167000 7.24e-02 3.43e-01 3.61e-01 6.92e-01 6.05e-02
Trafficking and processing of endosomal TLR 13 1.94e-01 2.64e-01 0.3880 0.300000 1.99e-01 1.44e-01 6.09e-02 2.13e-01 3.70e-01
Regulation of lipid metabolism by PPARalpha 106 3.74e-07 3.04e-06 0.3880 0.250000 2.86e-01 -8.04e-02 8.86e-06 3.77e-07 1.53e-01
FGFR1 mutant receptor activation 24 7.98e-02 1.29e-01 0.3880 0.210000 2.28e-01 2.33e-01 7.44e-02 5.36e-02 4.82e-02
Degradation of AXIN 53 4.17e-04 1.47e-03 0.3880 0.289000 2.05e-01 -1.58e-01 2.77e-04 9.93e-03 4.63e-02
Intrinsic Pathway of Fibrin Clot Formation 16 1.93e-01 2.63e-01 0.3880 0.266000 2.65e-01 -9.75e-02 6.57e-02 6.66e-02 4.99e-01
G alpha (z) signalling events 36 1.44e-02 3.13e-02 0.3870 0.271000 2.56e-01 -1.04e-01 4.90e-03 7.97e-03 2.82e-01
Prefoldin mediated transfer of substrate to CCT/TriC 26 6.40e-04 2.14e-03 0.3860 0.286000 4.59e-02 -2.55e-01 1.15e-02 6.86e-01 2.45e-02
Regulation of IFNA signaling 12 1.75e-01 2.43e-01 0.3860 0.182000 3.34e-01 6.63e-02 2.76e-01 4.52e-02 6.91e-01
The citric acid (TCA) cycle and respiratory electron transport 172 2.50e-17 6.19e-16 0.3830 0.238000 8.85e-02 -2.87e-01 7.58e-08 4.52e-02 7.68e-11
SCF-beta-TrCP mediated degradation of Emi1 53 2.15e-04 8.20e-04 0.3830 0.301000 1.83e-01 -1.52e-01 1.53e-04 2.15e-02 5.54e-02
Degradation of the extracellular matrix 77 3.91e-05 1.85e-04 0.3820 0.242000 2.90e-01 -5.73e-02 2.36e-04 1.06e-05 3.85e-01
Oxidative Stress Induced Senescence 79 3.29e-06 2.06e-05 0.3820 0.271000 1.83e-01 -1.98e-01 3.08e-05 4.83e-03 2.38e-03
NOTCH3 Intracellular Domain Regulates Transcription 20 1.40e-01 2.02e-01 0.3820 0.262000 2.70e-01 -6.45e-02 4.21e-02 3.64e-02 6.17e-01
Signaling by NOTCH3 42 3.71e-03 9.70e-03 0.3820 0.247000 2.53e-01 -1.45e-01 5.58e-03 4.52e-03 1.05e-01
HSF1 activation 26 4.34e-03 1.10e-02 0.3820 0.091600 -7.55e-02 -3.63e-01 4.19e-01 5.05e-01 1.37e-03
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 32 3.15e-02 6.00e-02 0.3810 0.278000 2.46e-01 -8.54e-02 6.43e-03 1.61e-02 4.03e-01
Early Phase of HIV Life Cycle 14 2.16e-01 2.87e-01 0.3810 -0.153000 -2.68e-01 -2.23e-01 3.21e-01 8.20e-02 1.49e-01
SARS-CoV-1 Infection 47 1.22e-03 3.69e-03 0.3810 0.242000 2.27e-01 -1.86e-01 4.05e-03 7.04e-03 2.75e-02
Toll Like Receptor 3 (TLR3) Cascade 92 1.85e-06 1.25e-05 0.3800 0.298000 2.07e-01 -1.16e-01 8.06e-07 6.09e-04 5.52e-02
Metabolism of nitric oxide: NOS3 activation and regulation 12 8.34e-02 1.34e-01 0.3800 0.279000 7.39e-02 -2.47e-01 9.47e-02 6.58e-01 1.39e-01
Effects of PIP2 hydrolysis 24 9.48e-03 2.17e-02 0.3790 -0.306000 -1.57e-01 -1.59e-01 9.41e-03 1.84e-01 1.77e-01
Regulation of PTEN gene transcription 59 1.14e-05 6.09e-05 0.3780 0.172000 7.34e-02 -3.29e-01 2.22e-02 3.30e-01 1.25e-05
Signaling by Insulin receptor 59 8.84e-04 2.80e-03 0.3780 0.294000 2.28e-01 -6.80e-02 9.52e-05 2.46e-03 3.66e-01
G-protein mediated events 44 3.38e-03 8.92e-03 0.3770 0.252000 2.30e-01 -1.59e-01 3.77e-03 8.33e-03 6.78e-02
Asparagine N-linked glycosylation 269 1.49e-15 3.28e-14 0.3760 0.273000 2.44e-01 -8.72e-02 1.14e-14 5.88e-12 1.38e-02
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 8.25e-02 1.32e-01 0.3760 0.036600 2.62e-01 2.67e-01 8.26e-01 1.16e-01 1.09e-01
Carnitine metabolism 10 3.48e-01 4.20e-01 0.3760 0.283000 1.93e-01 -1.56e-01 1.22e-01 2.90e-01 3.93e-01
Signaling by SCF-KIT 40 1.95e-02 4.00e-02 0.3760 0.261000 2.69e-01 -2.28e-02 4.26e-03 3.23e-03 8.03e-01
PRC2 methylates histones and DNA 29 7.50e-03 1.76e-02 0.3760 0.193000 1.04e-01 -3.05e-01 7.13e-02 3.32e-01 4.51e-03
Apoptotic factor-mediated response 18 1.14e-01 1.72e-01 0.3750 0.311000 2.01e-01 6.27e-02 2.25e-02 1.40e-01 6.45e-01
Degradation of beta-catenin by the destruction complex 83 4.64e-06 2.79e-05 0.3750 0.264000 1.91e-01 -1.86e-01 3.21e-05 2.58e-03 3.43e-03
Signaling by Hippo 18 2.33e-01 3.06e-01 0.3750 0.233000 2.45e-01 1.63e-01 8.72e-02 7.17e-02 2.32e-01
Syndecan interactions 19 1.21e-02 2.70e-02 0.3750 0.347000 1.28e-01 -6.45e-02 8.88e-03 3.34e-01 6.26e-01
Downregulation of ERBB2 signaling 24 5.85e-03 1.41e-02 0.3750 0.212000 2.91e-02 -3.08e-01 7.16e-02 8.05e-01 9.04e-03
Hedgehog 'on' state 75 4.31e-05 2.02e-04 0.3740 0.266000 2.12e-01 -1.55e-01 6.70e-05 1.49e-03 2.07e-02
Acyl chain remodelling of PC 19 1.62e-01 2.30e-01 0.3740 0.266000 2.45e-01 -9.48e-02 4.45e-02 6.49e-02 4.75e-01
Ca-dependent events 29 2.62e-02 5.15e-02 0.3740 0.247000 2.15e-01 -1.80e-01 2.14e-02 4.54e-02 9.28e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 53 8.98e-04 2.83e-03 0.3730 0.255000 2.10e-01 -1.71e-01 1.29e-03 8.11e-03 3.11e-02
PIWI-interacting RNA (piRNA) biogenesis 23 1.22e-02 2.71e-02 0.3720 0.026700 -1.49e-01 -3.40e-01 8.25e-01 2.18e-01 4.72e-03
SARS-CoV Infections 83 2.04e-05 1.03e-04 0.3720 0.249000 2.41e-01 -1.37e-01 9.02e-05 1.51e-04 3.10e-02
Intra-Golgi and retrograde Golgi-to-ER traffic 179 1.68e-09 1.80e-08 0.3710 0.268000 2.54e-01 -4.41e-02 6.47e-10 4.70e-09 3.08e-01
UCH proteinases 86 2.14e-06 1.39e-05 0.3710 0.232000 1.93e-01 -2.16e-01 1.98e-04 1.96e-03 5.34e-04
Plasma lipoprotein remodeling 18 1.70e-01 2.38e-01 0.3710 0.218000 2.98e-01 3.22e-02 1.10e-01 2.84e-02 8.13e-01
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 17 1.77e-01 2.46e-01 0.3710 0.293000 2.11e-01 -8.41e-02 3.64e-02 1.33e-01 5.48e-01
Potential therapeutics for SARS 36 2.54e-02 5.01e-02 0.3700 0.256000 2.57e-01 -7.25e-02 7.93e-03 7.64e-03 4.51e-01
Signaling by Receptor Tyrosine Kinases 411 2.83e-24 8.73e-23 0.3690 0.262000 2.30e-01 -1.22e-01 6.80e-20 1.35e-15 2.14e-05
Termination of translesion DNA synthesis 32 2.28e-02 4.60e-02 0.3690 -0.210000 -3.03e-01 -2.09e-02 3.95e-02 3.03e-03 8.38e-01
Signaling by VEGF 97 6.09e-06 3.52e-05 0.3690 0.253000 2.41e-01 -1.19e-01 1.70e-05 4.05e-05 4.34e-02
TNFR1-induced proapoptotic signaling 12 1.30e-01 1.91e-01 0.3690 -0.316000 -1.53e-01 -1.13e-01 5.81e-02 3.60e-01 4.97e-01
RNA Polymerase I Transcription Termination 30 4.41e-03 1.12e-02 0.3680 -0.140000 -3.20e-01 -1.18e-01 1.85e-01 2.45e-03 2.61e-01
Transport of Mature mRNA Derived from an Intronless Transcript 42 1.34e-02 2.94e-02 0.3680 -0.251000 -2.62e-01 6.16e-02 4.82e-03 3.32e-03 4.90e-01
TRAF6 mediated NF-kB activation 23 7.90e-02 1.28e-01 0.3680 0.271000 2.06e-01 -1.41e-01 2.46e-02 8.79e-02 2.42e-01
Asymmetric localization of PCP proteins 60 2.42e-04 9.12e-04 0.3680 0.258000 1.86e-01 -1.85e-01 5.35e-04 1.29e-02 1.33e-02
Chaperone Mediated Autophagy 20 1.41e-02 3.06e-02 0.3680 0.211000 1.59e-02 -3.01e-01 1.02e-01 9.02e-01 1.99e-02
Transcriptional regulation of white adipocyte differentiation 77 1.09e-04 4.47e-04 0.3670 0.248000 2.49e-01 -1.06e-01 1.68e-04 1.63e-04 1.09e-01
Translesion Synthesis by POLH 18 1.38e-01 2.01e-01 0.3670 -0.130000 -2.42e-01 -2.43e-01 3.40e-01 7.59e-02 7.40e-02
IRAK2 mediated activation of TAK1 complex 10 1.46e-01 2.10e-01 0.3660 0.250000 4.65e-02 -2.63e-01 1.70e-01 7.99e-01 1.50e-01
Caspase activation via Death Receptors in the presence of ligand 16 2.72e-01 3.46e-01 0.3650 0.255000 2.20e-01 1.41e-01 7.71e-02 1.28e-01 3.29e-01
Tie2 Signaling 16 3.06e-01 3.78e-01 0.3640 0.257000 2.33e-01 1.11e-01 7.51e-02 1.07e-01 4.41e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 16 3.00e-01 3.73e-01 0.3640 0.242000 2.71e-01 1.67e-02 9.42e-02 6.01e-02 9.08e-01
Initial triggering of complement 78 6.28e-13 1.09e-11 0.3630 -0.086600 -3.50e-01 -3.44e-02 1.86e-01 8.66e-08 5.99e-01
Recognition of DNA damage by PCNA-containing replication complex 30 3.03e-02 5.82e-02 0.3620 -0.168000 -2.88e-01 -1.43e-01 1.11e-01 6.40e-03 1.75e-01
p38MAPK events 13 2.52e-01 3.25e-01 0.3600 0.295000 1.83e-01 -9.64e-02 6.54e-02 2.53e-01 5.47e-01
cGMP effects 13 2.71e-01 3.45e-01 0.3600 0.303000 1.94e-01 -1.50e-02 5.85e-02 2.26e-01 9.26e-01
Base Excision Repair 58 2.27e-04 8.66e-04 0.3600 -0.062500 -1.36e-01 -3.27e-01 4.10e-01 7.23e-02 1.63e-05
Listeria monocytogenes entry into host cells 17 2.08e-01 2.78e-01 0.3590 0.240000 2.44e-01 -1.11e-01 8.70e-02 8.19e-02 4.28e-01
Stabilization of p53 54 9.98e-04 3.09e-03 0.3590 0.283000 1.85e-01 -1.22e-01 3.28e-04 1.84e-02 1.20e-01
N-Glycan antennae elongation 13 1.88e-02 3.88e-02 0.3590 -0.096200 6.57e-02 -3.40e-01 5.48e-01 6.82e-01 3.40e-02
Initiation of Nuclear Envelope (NE) Reformation 19 2.54e-01 3.26e-01 0.3590 0.252000 2.55e-01 1.66e-02 5.73e-02 5.40e-02 9.01e-01
Regulation of mRNA stability by proteins that bind AU-rich elements 87 2.21e-06 1.43e-05 0.3590 0.291000 1.68e-01 -1.25e-01 2.63e-06 6.64e-03 4.44e-02
Dectin-2 family 19 1.05e-01 1.62e-01 0.3590 0.160000 2.95e-01 1.26e-01 2.26e-01 2.58e-02 3.42e-01
Assembly of active LPL and LIPC lipase complexes 10 3.66e-01 4.36e-01 0.3590 0.207000 2.84e-01 -7.32e-02 2.58e-01 1.20e-01 6.89e-01
Constitutive Signaling by EGFRvIII 14 2.51e-01 3.24e-01 0.3590 0.290000 1.94e-01 8.33e-02 6.06e-02 2.08e-01 5.89e-01
Signaling by EGFRvIII in Cancer 14 2.51e-01 3.24e-01 0.3590 0.290000 1.94e-01 8.33e-02 6.06e-02 2.08e-01 5.89e-01
Macroautophagy 110 1.80e-07 1.55e-06 0.3580 0.270000 1.75e-01 -1.59e-01 1.01e-06 1.55e-03 4.06e-03
Costimulation by the CD28 family 74 5.00e-04 1.72e-03 0.3580 -0.223000 -2.08e-01 -1.87e-01 9.01e-04 2.01e-03 5.47e-03
Prostacyclin signalling through prostacyclin receptor 16 2.88e-01 3.62e-01 0.3570 0.257000 2.41e-01 -6.17e-02 7.57e-02 9.50e-02 6.69e-01
CDC6 association with the ORC:origin complex 11 1.60e-01 2.28e-01 0.3560 -0.039100 -7.04e-02 3.47e-01 8.22e-01 6.86e-01 4.61e-02
Signaling by Interleukins 383 1.23e-20 3.35e-19 0.3550 0.270000 2.11e-01 -9.07e-02 1.04e-19 1.18e-12 2.31e-03
Apoptosis 166 1.35e-08 1.33e-07 0.3540 0.278000 2.17e-01 -3.68e-02 6.69e-10 1.38e-06 4.13e-01
Autodegradation of Cdh1 by Cdh1:APC/C 64 9.80e-05 4.05e-04 0.3540 0.274000 1.56e-01 -1.60e-01 1.52e-04 3.04e-02 2.66e-02
Vesicle-mediated transport 646 4.37e-32 1.75e-30 0.3530 0.271000 2.20e-01 -5.62e-02 6.34e-32 1.44e-21 1.49e-02
Metabolism of RNA 685 7.68e-52 5.22e-50 0.3520 -0.089700 -2.48e-01 -2.34e-01 6.29e-05 1.77e-28 1.63e-25
Programmed Cell Death 169 1.65e-08 1.61e-07 0.3520 0.275000 2.18e-01 -2.70e-02 6.51e-10 1.00e-06 5.46e-01
Regulation of insulin secretion 60 2.66e-03 7.23e-03 0.3520 0.255000 2.28e-01 -8.18e-02 6.19e-04 2.26e-03 2.73e-01
Metalloprotease DUBs 21 2.12e-01 2.83e-01 0.3520 0.265000 2.31e-01 3.40e-03 3.53e-02 6.68e-02 9.78e-01
Myogenesis 21 1.88e-01 2.57e-01 0.3520 0.272000 2.21e-01 -2.94e-02 3.10e-02 7.96e-02 8.16e-01
Signaling by FGFR1 in disease 31 3.51e-02 6.56e-02 0.3510 0.167000 1.63e-01 2.62e-01 1.07e-01 1.16e-01 1.17e-02
Role of LAT2/NTAL/LAB on calcium mobilization 74 4.26e-14 8.27e-13 0.3510 -0.024100 -3.32e-01 -1.11e-01 7.20e-01 7.97e-07 1.00e-01
Transport of Mature mRNAs Derived from Intronless Transcripts 43 1.63e-02 3.46e-02 0.3500 -0.231000 -2.56e-01 5.92e-02 8.74e-03 3.68e-03 5.02e-01
Signaling by Non-Receptor Tyrosine Kinases 48 2.09e-03 5.88e-03 0.3490 0.278000 1.67e-01 -1.28e-01 8.49e-04 4.54e-02 1.26e-01
Signaling by PTK6 48 2.09e-03 5.88e-03 0.3490 0.278000 1.67e-01 -1.28e-01 8.49e-04 4.54e-02 1.26e-01
MASTL Facilitates Mitotic Progression 10 4.09e-01 4.82e-01 0.3490 0.287000 1.85e-01 7.18e-02 1.17e-01 3.11e-01 6.94e-01
RUNX3 regulates NOTCH signaling 14 2.71e-01 3.45e-01 0.3490 0.212000 2.59e-01 -9.77e-02 1.69e-01 9.39e-02 5.27e-01
Telomere Maintenance 80 1.01e-05 5.46e-05 0.3480 -0.046700 -1.49e-01 -3.11e-01 4.70e-01 2.14e-02 1.51e-06
Apoptotic execution phase 45 3.20e-02 6.08e-02 0.3480 0.244000 2.41e-01 5.69e-02 4.62e-03 5.09e-03 5.09e-01
Interleukin-15 signaling 14 3.74e-01 4.44e-01 0.3480 0.234000 2.54e-01 -3.46e-02 1.29e-01 9.93e-02 8.22e-01
Collagen biosynthesis and modifying enzymes 46 3.87e-04 1.38e-03 0.3470 0.119000 1.30e-01 -2.99e-01 1.64e-01 1.26e-01 4.55e-04
Nef mediated downregulation of MHC class I complex cell surface expression 10 2.28e-01 3.01e-01 0.3460 0.168000 8.57e-03 -3.03e-01 3.59e-01 9.63e-01 9.70e-02
Translation of structural proteins 28 1.47e-02 3.18e-02 0.3460 0.135000 1.32e-01 -2.90e-01 2.16e-01 2.26e-01 7.93e-03
SHC1 events in ERBB4 signaling 10 1.23e-01 1.83e-01 0.3460 0.329000 1.03e-01 -1.81e-02 7.14e-02 5.71e-01 9.21e-01
Collagen formation 64 1.01e-04 4.15e-04 0.3460 0.182000 1.72e-01 -2.39e-01 1.20e-02 1.75e-02 9.63e-04
Defects in vitamin and cofactor metabolism 21 2.34e-01 3.06e-01 0.3450 -0.252000 -2.36e-01 5.27e-03 4.52e-02 6.14e-02 9.67e-01
MicroRNA (miRNA) biogenesis 24 2.58e-02 5.07e-02 0.3450 0.064000 -6.43e-02 -3.33e-01 5.88e-01 5.85e-01 4.71e-03
SUMOylation of intracellular receptors 25 8.12e-02 1.31e-01 0.3450 0.219000 2.31e-01 -1.34e-01 5.85e-02 4.53e-02 2.46e-01
RHO GTPase Effectors 249 4.39e-11 6.03e-10 0.3450 0.242000 2.46e-01 -1.91e-02 4.94e-11 2.36e-11 6.03e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 51 2.56e-03 7.01e-03 0.3450 0.287000 1.85e-01 4.83e-02 3.84e-04 2.22e-02 5.51e-01
Signaling by FGFR3 31 7.15e-02 1.18e-01 0.3450 0.270000 2.12e-01 -3.34e-02 9.19e-03 4.10e-02 7.47e-01
Formation of tubulin folding intermediates by CCT/TriC 22 1.80e-02 3.75e-02 0.3450 0.286000 9.55e-02 -1.67e-01 2.02e-02 4.38e-01 1.74e-01
Role of phospholipids in phagocytosis 88 3.04e-11 4.30e-10 0.3440 -0.081500 -3.18e-01 -1.02e-01 1.86e-01 2.43e-07 9.71e-02
SUMOylation of SUMOylation proteins 35 3.93e-02 7.23e-02 0.3440 -0.213000 -2.69e-01 1.87e-02 2.91e-02 5.88e-03 8.48e-01
APC/C:Cdc20 mediated degradation of Securin 66 1.95e-04 7.53e-04 0.3440 0.267000 1.61e-01 -1.44e-01 1.72e-04 2.35e-02 4.34e-02
Cytosolic tRNA aminoacylation 24 7.60e-03 1.78e-02 0.3430 -0.133000 -2.64e-01 1.74e-01 2.58e-01 2.50e-02 1.41e-01
Keratinization 32 1.16e-02 2.59e-02 0.3430 0.262000 1.29e-01 -1.79e-01 1.03e-02 2.05e-01 7.93e-02
Interleukin-4 and Interleukin-13 signaling 90 2.07e-06 1.35e-05 0.3430 0.295000 1.61e-01 -6.51e-02 1.26e-06 8.39e-03 2.85e-01
Beta-catenin independent WNT signaling 136 9.95e-08 8.96e-07 0.3420 0.233000 1.97e-01 -1.55e-01 2.68e-06 7.16e-05 1.79e-03
Constitutive Signaling by Overexpressed ERBB2 11 5.13e-01 5.78e-01 0.3410 0.243000 2.10e-01 1.16e-01 1.62e-01 2.28e-01 5.07e-01
TCF dependent signaling in response to WNT 165 1.81e-10 2.24e-09 0.3410 0.215000 1.60e-01 -2.11e-01 1.83e-06 3.96e-04 2.93e-06
Chemokine receptors bind chemokines 37 2.29e-02 4.62e-02 0.3410 -0.146000 -1.61e-01 -2.63e-01 1.25e-01 9.07e-02 5.66e-03
HDR through Homologous Recombination (HRR) 66 1.49e-03 4.42e-03 0.3400 -0.237000 -2.18e-01 1.08e-01 8.81e-04 2.16e-03 1.29e-01
Mitochondrial iron-sulfur cluster biogenesis 13 6.57e-02 1.11e-01 0.3390 0.255000 2.76e-02 -2.22e-01 1.12e-01 8.63e-01 1.67e-01
Regulation of RAS by GAPs 66 1.23e-03 3.69e-03 0.3390 0.251000 1.97e-01 -1.13e-01 4.15e-04 5.59e-03 1.13e-01
Collagen chain trimerization 27 2.69e-02 5.25e-02 0.3380 0.024600 -5.25e-02 -3.33e-01 8.25e-01 6.36e-01 2.73e-03
Transcriptional regulation of pluripotent stem cells 19 2.78e-01 3.52e-01 0.3370 0.181000 2.22e-01 1.78e-01 1.72e-01 9.32e-02 1.80e-01
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 14 4.35e-01 5.08e-01 0.3370 0.233000 2.44e-01 -1.23e-03 1.31e-01 1.14e-01 9.94e-01
C-type lectin receptors (CLRs) 128 1.03e-06 7.68e-06 0.3370 0.264000 1.92e-01 -8.61e-02 2.51e-07 1.79e-04 9.26e-02
Aggrephagy 22 4.64e-02 8.35e-02 0.3370 0.242000 9.97e-02 -2.13e-01 4.98e-02 4.18e-01 8.43e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 72 3.13e-04 1.13e-03 0.3360 0.263000 1.76e-01 -1.15e-01 1.16e-04 9.96e-03 9.16e-02
Sphingolipid metabolism 77 1.73e-03 5.01e-03 0.3360 0.223000 2.51e-01 1.15e-02 7.14e-04 1.39e-04 8.61e-01
Mitophagy 28 4.08e-04 1.45e-03 0.3360 0.180000 -8.04e-02 -2.72e-01 9.98e-02 4.61e-01 1.27e-02
TRAF6 mediated IRF7 activation 15 2.04e-01 2.74e-01 0.3360 0.061800 1.86e-01 2.73e-01 6.78e-01 2.13e-01 6.75e-02
Synthesis of PE 12 2.83e-01 3.56e-01 0.3360 -0.185000 -1.13e-01 2.56e-01 2.66e-01 4.96e-01 1.25e-01
SHC1 events in ERBB2 signaling 17 2.52e-01 3.24e-01 0.3350 0.276000 1.89e-01 -1.19e-02 4.86e-02 1.77e-01 9.32e-01
COPI-dependent Golgi-to-ER retrograde traffic 78 1.87e-03 5.34e-03 0.3340 0.230000 2.42e-01 -3.67e-03 4.48e-04 2.17e-04 9.55e-01
Heparan sulfate/heparin (HS-GAG) metabolism 37 3.80e-03 9.85e-03 0.3330 0.111000 1.15e-01 -2.92e-01 2.44e-01 2.28e-01 2.08e-03
NGF-stimulated transcription 31 3.07e-02 5.89e-02 0.3330 0.245000 1.47e-01 -1.71e-01 1.84e-02 1.57e-01 9.86e-02
N-glycan antennae elongation in the medial/trans-Golgi 21 1.36e-02 2.99e-02 0.3320 -0.026500 6.09e-02 -3.26e-01 8.34e-01 6.29e-01 9.80e-03
MAPK6/MAPK4 signaling 81 4.97e-05 2.24e-04 0.3320 0.278000 1.64e-01 -7.87e-02 1.54e-05 1.07e-02 2.21e-01
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 53 3.02e-03 8.08e-03 0.3320 0.254000 1.66e-01 -1.34e-01 1.36e-03 3.65e-02 9.17e-02
Constitutive Signaling by NOTCH1 PEST Domain Mutants 53 3.02e-03 8.08e-03 0.3320 0.254000 1.66e-01 -1.34e-01 1.36e-03 3.65e-02 9.17e-02
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 53 3.02e-03 8.08e-03 0.3320 0.254000 1.66e-01 -1.34e-01 1.36e-03 3.65e-02 9.17e-02
Signaling by NOTCH1 PEST Domain Mutants in Cancer 53 3.02e-03 8.08e-03 0.3320 0.254000 1.66e-01 -1.34e-01 1.36e-03 3.65e-02 9.17e-02
Signaling by NOTCH1 in Cancer 53 3.02e-03 8.08e-03 0.3320 0.254000 1.66e-01 -1.34e-01 1.36e-03 3.65e-02 9.17e-02
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 84 1.98e-11 2.90e-10 0.3310 -0.041100 -2.98e-01 -1.39e-01 5.15e-01 2.40e-06 2.74e-02
Receptor Mediated Mitophagy 11 3.73e-01 4.43e-01 0.3310 0.285000 1.65e-01 -3.14e-02 1.02e-01 3.43e-01 8.57e-01
Mitotic Telophase/Cytokinesis 13 1.92e-01 2.61e-01 0.3300 0.272000 1.37e-01 1.27e-01 9.00e-02 3.93e-01 4.27e-01
Oncogene Induced Senescence 33 5.93e-02 1.02e-01 0.3300 0.225000 2.13e-01 -1.13e-01 2.52e-02 3.43e-02 2.63e-01
O-glycosylation of TSR domain-containing proteins 26 4.32e-02 7.86e-02 0.3290 -0.290000 -1.55e-01 3.21e-03 1.04e-02 1.71e-01 9.77e-01
Transcriptional Regulation by E2F6 34 5.16e-02 9.07e-02 0.3290 -0.211000 -2.38e-01 8.30e-02 3.32e-02 1.63e-02 4.02e-01
Purine catabolism 16 7.51e-02 1.22e-01 0.3280 0.088100 -9.40e-02 -3.02e-01 5.42e-01 5.15e-01 3.65e-02
Signaling by WNT 253 1.45e-13 2.66e-12 0.3270 0.218000 1.77e-01 -1.69e-01 2.42e-09 1.31e-06 3.70e-06
SHC-mediated cascade:FGFR1 12 3.81e-01 4.52e-01 0.3270 0.098900 1.36e-01 2.80e-01 5.53e-01 4.15e-01 9.31e-02
Retinoid metabolism and transport 24 1.71e-01 2.39e-01 0.3260 0.207000 2.51e-01 -2.37e-02 7.96e-02 3.35e-02 8.41e-01
NR1H2 and NR1H3-mediated signaling 39 1.68e-02 3.54e-02 0.3260 0.195000 2.00e-01 -1.68e-01 3.55e-02 3.06e-02 6.97e-02
Intra-Golgi traffic 43 4.57e-02 8.24e-02 0.3260 0.226000 2.33e-01 -2.15e-02 1.03e-02 8.13e-03 8.08e-01
Dual Incision in GG-NER 41 2.56e-02 5.05e-02 0.3260 -0.168000 -2.63e-01 -9.29e-02 6.20e-02 3.60e-03 3.03e-01
Regulation of TP53 Activity through Methylation 19 2.28e-01 3.01e-01 0.3260 -0.120000 -1.98e-01 -2.29e-01 3.64e-01 1.35e-01 8.43e-02
Glycosaminoglycan metabolism 92 9.35e-07 6.99e-06 0.3250 0.148000 1.86e-01 -2.23e-01 1.44e-02 2.09e-03 2.25e-04
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 33 3.12e-02 5.98e-02 0.3250 0.188000 2.32e-01 -1.28e-01 6.22e-02 2.11e-02 2.03e-01
ESR-mediated signaling 160 6.62e-10 7.38e-09 0.3230 0.241000 1.32e-01 -1.71e-01 1.45e-07 4.04e-03 1.95e-04
Norepinephrine Neurotransmitter Release Cycle 13 3.00e-01 3.73e-01 0.3220 -0.033800 -1.15e-01 -2.99e-01 8.33e-01 4.72e-01 6.18e-02
Synthesis of IP3 and IP4 in the cytosol 22 2.82e-02 5.47e-02 0.3220 0.094500 1.62e-01 -2.62e-01 4.43e-01 1.87e-01 3.36e-02
FCERI mediated Ca+2 mobilization 89 1.19e-11 1.77e-10 0.3220 -0.052700 -3.01e-01 -1.02e-01 3.90e-01 9.50e-07 9.71e-02
PTEN Regulation 138 1.47e-07 1.28e-06 0.3220 0.218000 1.57e-01 -1.77e-01 9.74e-06 1.46e-03 3.37e-04
CaM pathway 27 7.30e-02 1.20e-01 0.3210 0.199000 1.62e-01 -1.94e-01 7.34e-02 1.46e-01 8.12e-02
Calmodulin induced events 27 7.30e-02 1.20e-01 0.3210 0.199000 1.62e-01 -1.94e-01 7.34e-02 1.46e-01 8.12e-02
Hemostasis 544 8.77e-26 2.77e-24 0.3210 0.250000 1.77e-01 -9.63e-02 1.80e-23 1.59e-12 1.23e-04
Activation of HOX genes during differentiation 68 4.97e-04 1.71e-03 0.3210 0.197000 1.55e-01 -2.01e-01 4.99e-03 2.75e-02 4.17e-03
Activation of anterior HOX genes in hindbrain development during early embryogenesis 68 4.97e-04 1.71e-03 0.3210 0.197000 1.55e-01 -2.01e-01 4.99e-03 2.75e-02 4.17e-03
Glycerophospholipid biosynthesis 106 9.22e-05 3.84e-04 0.3200 0.239000 1.98e-01 -8.03e-02 2.16e-05 4.27e-04 1.53e-01
Sialic acid metabolism 28 1.02e-01 1.59e-01 0.3200 0.208000 2.14e-01 -1.14e-01 5.69e-02 4.97e-02 2.94e-01
Sphingolipid de novo biosynthesis 41 7.47e-02 1.22e-01 0.3190 0.211000 2.11e-01 1.15e-01 1.97e-02 1.94e-02 2.04e-01
Estrogen-dependent gene expression 98 1.08e-06 8.00e-06 0.3190 0.215000 9.51e-02 -2.16e-01 2.31e-04 1.04e-01 2.23e-04
Nuclear signaling by ERBB4 24 7.88e-02 1.28e-01 0.3190 0.239000 1.28e-01 -1.68e-01 4.27e-02 2.79e-01 1.55e-01
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 18 1.03e-01 1.59e-01 0.3190 0.280000 1.23e-01 -8.96e-02 3.96e-02 3.67e-01 5.11e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer 18 1.03e-01 1.59e-01 0.3190 0.280000 1.23e-01 -8.96e-02 3.96e-02 3.67e-01 5.11e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 36 4.19e-02 7.65e-02 0.3190 0.263000 1.73e-01 -4.81e-02 6.34e-03 7.17e-02 6.17e-01
DAP12 interactions 39 2.66e-02 5.21e-02 0.3180 0.193000 2.36e-01 -9.34e-02 3.73e-02 1.09e-02 3.13e-01
PKA-mediated phosphorylation of CREB 17 2.01e-01 2.71e-01 0.3180 0.184000 1.32e-01 -2.24e-01 1.89e-01 3.45e-01 1.11e-01
Downstream signaling events of B Cell Receptor (BCR) 79 1.80e-04 7.05e-04 0.3180 0.243000 1.51e-01 -1.40e-01 1.93e-04 2.05e-02 3.12e-02
Signaling by FGFR4 31 6.52e-02 1.10e-01 0.3180 0.256000 1.67e-01 -8.71e-02 1.37e-02 1.07e-01 4.01e-01
Long-term potentiation 14 3.31e-01 4.04e-01 0.3180 -0.133000 -2.49e-01 -1.46e-01 3.91e-01 1.07e-01 3.44e-01
FGFR2 alternative splicing 25 2.50e-02 4.97e-02 0.3180 0.058700 -1.03e-01 -2.95e-01 6.11e-01 3.73e-01 1.08e-02
SUMOylation of RNA binding proteins 47 2.35e-02 4.73e-02 0.3170 -0.181000 -2.55e-01 -5.37e-02 3.16e-02 2.48e-03 5.25e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity 20 1.11e-01 1.69e-01 0.3170 0.162000 2.19e-01 -1.62e-01 2.09e-01 9.03e-02 2.10e-01
Trafficking of AMPA receptors 20 1.11e-01 1.69e-01 0.3170 0.162000 2.19e-01 -1.62e-01 2.09e-01 9.03e-02 2.10e-01
TP53 Regulates Metabolic Genes 84 1.55e-04 6.17e-04 0.3170 0.235000 1.56e-01 -1.45e-01 2.03e-04 1.35e-02 2.18e-02
CDT1 association with the CDC6:ORC:origin complex 57 2.48e-03 6.83e-03 0.3160 0.258000 1.54e-01 -9.91e-02 7.53e-04 4.40e-02 1.95e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat 42 3.76e-03 9.78e-03 0.3150 0.102000 -4.91e-03 -2.98e-01 2.54e-01 9.56e-01 8.41e-04
HIV Transcription Elongation 42 3.76e-03 9.78e-03 0.3150 0.102000 -4.91e-03 -2.98e-01 2.54e-01 9.56e-01 8.41e-04
Tat-mediated elongation of the HIV-1 transcript 42 3.76e-03 9.78e-03 0.3150 0.102000 -4.91e-03 -2.98e-01 2.54e-01 9.56e-01 8.41e-04
Signaling by FGFR2 IIIa TM 18 6.08e-02 1.05e-01 0.3150 0.137000 -4.14e-02 -2.80e-01 3.16e-01 7.61e-01 3.95e-02
Inwardly rectifying K+ channels 23 2.85e-01 3.59e-01 0.3140 0.219000 2.05e-01 9.52e-02 6.96e-02 8.94e-02 4.29e-01
Resolution of D-loop Structures through Holliday Junction Intermediates 32 2.31e-02 4.66e-02 0.3140 -0.179000 -8.03e-02 2.45e-01 7.90e-02 4.32e-01 1.64e-02
Transport of bile salts and organic acids, metal ions and amine compounds 54 3.46e-02 6.48e-02 0.3140 0.220000 2.20e-01 4.01e-02 5.10e-03 5.19e-03 6.10e-01
RA biosynthesis pathway 13 2.16e-01 2.87e-01 0.3140 -0.254000 -1.25e-01 -1.35e-01 1.13e-01 4.36e-01 3.98e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 17 3.22e-01 3.95e-01 0.3130 -0.131000 -2.13e-01 -1.88e-01 3.50e-01 1.28e-01 1.79e-01
Negative regulation of FGFR2 signaling 23 1.23e-01 1.83e-01 0.3130 0.208000 1.37e-01 -1.89e-01 8.46e-02 2.54e-01 1.16e-01
Nuclear Pore Complex (NPC) Disassembly 36 4.87e-02 8.65e-02 0.3120 -0.188000 -2.44e-01 4.94e-02 5.14e-02 1.12e-02 6.08e-01
Metabolism of fat-soluble vitamins 28 1.30e-01 1.91e-01 0.3110 0.206000 2.13e-01 -9.53e-02 5.98e-02 5.08e-02 3.83e-01
Diseases of signal transduction by growth factor receptors and second messengers 340 1.08e-13 2.02e-12 0.3110 0.229000 1.93e-01 -8.01e-02 3.47e-13 8.98e-10 1.12e-02
Chaperonin-mediated protein folding 84 7.90e-04 2.53e-03 0.3100 0.226000 1.83e-01 -1.06e-01 3.40e-04 3.74e-03 9.16e-02
Bile acid and bile salt metabolism 28 1.37e-01 1.99e-01 0.3090 0.152000 2.40e-01 1.22e-01 1.63e-01 2.82e-02 2.65e-01
FRS-mediated FGFR1 signaling 14 3.61e-01 4.32e-01 0.3080 0.136000 1.29e-01 2.44e-01 3.77e-01 4.04e-01 1.13e-01
Signalling to RAS 18 1.67e-01 2.35e-01 0.3080 0.269000 1.44e-01 4.35e-02 4.85e-02 2.90e-01 7.50e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids 11 3.08e-01 3.80e-01 0.3080 0.163000 3.05e-02 -2.60e-01 3.51e-01 8.61e-01 1.36e-01
Signaling by FGFR1 38 1.06e-01 1.62e-01 0.3080 0.198000 2.32e-01 4.49e-02 3.50e-02 1.35e-02 6.32e-01
RNA Polymerase III Transcription Initiation 36 9.18e-02 1.45e-01 0.3070 -0.175000 -1.77e-01 -1.81e-01 6.92e-02 6.65e-02 6.07e-02
Signaling by PDGFR in disease 19 2.65e-01 3.39e-01 0.3070 0.164000 1.48e-01 2.13e-01 2.16e-01 2.63e-01 1.08e-01
p75NTR recruits signalling complexes 12 1.49e-01 2.14e-01 0.3070 0.246000 4.30e-02 -1.78e-01 1.41e-01 7.97e-01 2.85e-01
RET signaling 32 1.15e-01 1.74e-01 0.3060 0.198000 2.30e-01 -4.10e-02 5.25e-02 2.44e-02 6.88e-01
DNA Damage/Telomere Stress Induced Senescence 44 1.84e-02 3.82e-02 0.3060 0.191000 1.65e-01 -1.73e-01 2.80e-02 5.89e-02 4.72e-02
HS-GAG biosynthesis 20 1.72e-01 2.39e-01 0.3040 0.166000 1.46e-01 -2.09e-01 1.99e-01 2.60e-01 1.05e-01
MHC class II antigen presentation 101 4.66e-04 1.63e-03 0.3040 0.208000 2.13e-01 -6.28e-02 3.00e-04 2.22e-04 2.75e-01
TICAM1, RIP1-mediated IKK complex recruitment 19 2.87e-01 3.60e-01 0.3030 0.247000 1.70e-01 4.72e-02 6.28e-02 2.00e-01 7.21e-01
Synaptic adhesion-like molecules 14 1.02e-01 1.59e-01 0.3020 0.071200 1.79e-01 -2.33e-01 6.45e-01 2.47e-01 1.31e-01
Extra-nuclear estrogen signaling 66 1.46e-03 4.34e-03 0.3020 0.243000 1.43e-01 -1.08e-01 6.26e-04 4.53e-02 1.28e-01
Positive epigenetic regulation of rRNA expression 62 1.13e-04 4.59e-04 0.3020 0.073900 -7.53e-02 -2.83e-01 3.14e-01 3.05e-01 1.17e-04
CDK-mediated phosphorylation and removal of Cdc6 71 6.82e-04 2.24e-03 0.3020 0.242000 1.38e-01 -1.16e-01 4.13e-04 4.50e-02 9.09e-02
TICAM1,TRAF6-dependent induction of TAK1 complex 11 1.69e-01 2.37e-01 0.3020 0.277000 6.74e-02 -9.92e-02 1.12e-01 6.99e-01 5.69e-01
Metabolism of steroids 117 2.45e-04 9.19e-04 0.3010 0.188000 2.33e-01 2.99e-02 4.35e-04 1.29e-05 5.77e-01
Antiviral mechanism by IFN-stimulated genes 80 2.09e-04 8.03e-04 0.3010 -0.187000 -1.17e-01 2.05e-01 3.78e-03 6.93e-02 1.56e-03
FRS-mediated FGFR3 signaling 11 2.58e-01 3.32e-01 0.3010 0.181000 7.31e-02 2.29e-01 2.99e-01 6.74e-01 1.89e-01
Resolution of D-Loop Structures 33 2.28e-02 4.60e-02 0.3010 -0.183000 -6.68e-02 2.29e-01 6.93e-02 5.06e-01 2.25e-02
SCF(Skp2)-mediated degradation of p27/p21 60 5.32e-03 1.30e-02 0.3010 0.243000 1.56e-01 -8.26e-02 1.12e-03 3.67e-02 2.68e-01
Signaling by Rho GTPases 365 1.17e-12 1.85e-11 0.3000 0.207000 2.15e-01 -3.16e-02 1.13e-11 1.56e-12 3.01e-01
Biosynthesis of DHA-derived SPMs 14 3.32e-01 4.04e-01 0.3000 0.203000 1.18e-01 -1.87e-01 1.89e-01 4.45e-01 2.26e-01
Cellular Senescence 144 3.95e-07 3.18e-06 0.3000 0.192000 1.40e-01 -1.84e-01 7.21e-05 3.80e-03 1.41e-04
RNA Polymerase I Promoter Clearance 66 9.26e-05 3.84e-04 0.3000 0.051200 -9.40e-02 -2.80e-01 4.72e-01 1.86e-01 8.26e-05
RNA Polymerase I Transcription 66 9.26e-05 3.84e-04 0.3000 0.051200 -9.40e-02 -2.80e-01 4.72e-01 1.86e-01 8.26e-05
Signaling by Nuclear Receptors 216 5.57e-11 7.43e-10 0.2990 0.212000 1.25e-01 -1.70e-01 8.02e-08 1.52e-03 1.72e-05
Maturation of nucleoprotein 10 2.27e-01 3.00e-01 0.2990 -0.174000 2.62e-02 2.41e-01 3.40e-01 8.86e-01 1.87e-01
Defective B3GALTL causes Peters-plus syndrome (PpS) 25 6.84e-02 1.14e-01 0.2980 -0.268000 -1.31e-01 1.78e-02 2.05e-02 2.58e-01 8.77e-01
Cellular responses to stress 499 1.50e-32 6.36e-31 0.2980 0.141000 1.40e-02 -2.63e-01 6.99e-08 5.91e-01 8.95e-24
Acyl chain remodelling of PG 11 6.10e-01 6.66e-01 0.2980 0.231000 1.86e-01 -2.83e-02 1.84e-01 2.84e-01 8.71e-01
Metabolism of carbohydrates 241 8.19e-13 1.41e-11 0.2980 0.152000 1.42e-01 -2.13e-01 4.62e-05 1.51e-04 1.28e-08
Gap-filling DNA repair synthesis and ligation in TC-NER 64 6.44e-04 2.14e-03 0.2970 -0.031700 -1.61e-01 -2.48e-01 6.61e-01 2.55e-02 6.15e-04
Nuclear Receptor transcription pathway 36 1.43e-02 3.10e-02 0.2970 0.010800 1.00e-02 -2.97e-01 9.10e-01 9.17e-01 2.06e-03
Carboxyterminal post-translational modifications of tubulin 26 1.51e-01 2.16e-01 0.2970 0.170000 2.43e-01 -1.28e-02 1.33e-01 3.18e-02 9.10e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 36 4.02e-02 7.38e-02 0.2970 0.245000 1.40e-01 -9.18e-02 1.10e-02 1.46e-01 3.40e-01
Downstream signaling of activated FGFR1 20 2.15e-01 2.86e-01 0.2970 0.090900 1.07e-01 2.62e-01 4.82e-01 4.09e-01 4.29e-02
Formation of the Early Elongation Complex 33 1.74e-02 3.64e-02 0.2970 0.122000 -5.71e-03 -2.70e-01 2.27e-01 9.55e-01 7.18e-03
Formation of the HIV-1 Early Elongation Complex 33 1.74e-02 3.64e-02 0.2970 0.122000 -5.71e-03 -2.70e-01 2.27e-01 9.55e-01 7.18e-03
Other semaphorin interactions 16 2.81e-01 3.56e-01 0.2960 0.167000 1.18e-01 -2.14e-01 2.48e-01 4.12e-01 1.38e-01
Cellular responses to external stimuli 505 4.03e-32 1.66e-30 0.2960 0.145000 2.09e-02 -2.57e-01 2.44e-08 4.21e-01 3.95e-23
Protein folding 90 7.32e-04 2.39e-03 0.2960 0.204000 1.78e-01 -1.20e-01 8.33e-04 3.52e-03 4.94e-02
Negative regulation of NMDA receptor-mediated neuronal transmission 14 4.40e-01 5.11e-01 0.2960 -0.192000 -1.51e-01 -1.67e-01 2.14e-01 3.27e-01 2.80e-01
Arachidonic acid metabolism 43 4.76e-02 8.47e-02 0.2960 0.194000 2.02e-01 -9.35e-02 2.77e-02 2.16e-02 2.89e-01
p53-Dependent G1 DNA Damage Response 63 5.75e-03 1.39e-02 0.2950 0.234000 1.56e-01 -9.11e-02 1.34e-03 3.21e-02 2.11e-01
p53-Dependent G1/S DNA damage checkpoint 63 5.75e-03 1.39e-02 0.2950 0.234000 1.56e-01 -9.11e-02 1.34e-03 3.21e-02 2.11e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript 72 2.30e-03 6.41e-03 0.2950 -0.156000 -2.46e-01 -4.60e-02 2.18e-02 3.00e-04 4.99e-01
ABC-family proteins mediated transport 93 9.97e-05 4.11e-04 0.2930 0.224000 1.29e-01 -1.40e-01 1.92e-04 3.20e-02 1.98e-02
PI3K events in ERBB2 signaling 11 1.66e-01 2.34e-01 0.2930 0.244000 2.90e-02 -1.59e-01 1.61e-01 8.68e-01 3.61e-01
RIP-mediated NFkB activation via ZBP1 17 4.12e-01 4.84e-01 0.2930 0.194000 2.12e-01 -5.70e-02 1.67e-01 1.31e-01 6.84e-01
Assembly of collagen fibrils and other multimeric structures 42 2.21e-02 4.49e-02 0.2920 0.167000 1.26e-01 -2.05e-01 6.18e-02 1.59e-01 2.16e-02
ZBP1(DAI) mediated induction of type I IFNs 20 3.11e-01 3.83e-01 0.2920 0.188000 2.10e-01 -7.54e-02 1.46e-01 1.04e-01 5.60e-01
Pyruvate metabolism 28 1.37e-01 2.00e-01 0.2910 0.244000 1.57e-01 2.00e-02 2.52e-02 1.50e-01 8.54e-01
Metabolism of amino acids and derivatives 322 9.24e-22 2.65e-20 0.2910 -0.005160 -1.68e-01 -2.37e-01 8.74e-01 2.05e-07 2.48e-13
Cdc20:Phospho-APC/C mediated degradation of Cyclin A 71 7.36e-04 2.40e-03 0.2900 0.243000 1.28e-01 -9.46e-02 3.99e-04 6.26e-02 1.68e-01
Negative regulation of MAPK pathway 42 4.98e-02 8.83e-02 0.2890 0.189000 1.81e-01 -1.24e-01 3.44e-02 4.24e-02 1.66e-01
B-WICH complex positively regulates rRNA expression 47 9.38e-04 2.93e-03 0.2890 0.144000 -2.09e-02 -2.50e-01 8.68e-02 8.05e-01 3.07e-03
RUNX3 regulates p14-ARF 10 5.38e-01 6.03e-01 0.2890 0.126000 2.39e-01 1.02e-01 4.91e-01 1.90e-01 5.78e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 72 9.43e-04 2.94e-03 0.2880 0.242000 1.32e-01 -8.53e-02 3.85e-04 5.31e-02 2.11e-01
Signaling by ERBB4 44 2.79e-02 5.43e-02 0.2880 0.244000 1.46e-01 -4.54e-02 5.07e-03 9.29e-02 6.02e-01
mRNA Splicing - Major Pathway 179 9.72e-11 1.26e-09 0.2880 -0.006170 -1.46e-01 -2.48e-01 8.87e-01 7.60e-04 1.00e-08
Transcriptional regulation by RUNX3 90 1.83e-03 5.26e-03 0.2880 0.206000 1.79e-01 -8.97e-02 7.12e-04 3.28e-03 1.41e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 75 1.07e-03 3.29e-03 0.2880 0.240000 1.38e-01 -7.99e-02 3.35e-04 3.94e-02 2.32e-01
Striated Muscle Contraction 23 1.12e-01 1.70e-01 0.2870 0.253000 1.21e-01 -5.95e-02 3.54e-02 3.13e-01 6.21e-01
Purine salvage 12 3.70e-01 4.40e-01 0.2870 0.211000 8.92e-02 -1.74e-01 2.06e-01 5.92e-01 2.98e-01
Heme biosynthesis 14 4.58e-01 5.30e-01 0.2870 0.238000 1.57e-01 -3.38e-02 1.23e-01 3.10e-01 8.27e-01
PIP3 activates AKT signaling 239 5.47e-10 6.20e-09 0.2870 0.190000 1.51e-01 -1.52e-01 4.02e-07 5.48e-05 5.22e-05
Processing of Capped Intronless Pre-mRNA 28 6.18e-02 1.06e-01 0.2870 -0.050900 -1.92e-01 -2.07e-01 6.41e-01 7.93e-02 5.77e-02
SUMOylation of ubiquitinylation proteins 39 6.64e-02 1.12e-01 0.2860 -0.180000 -1.98e-01 1.02e-01 5.14e-02 3.23e-02 2.73e-01
Viral Messenger RNA Synthesis 44 5.54e-02 9.66e-02 0.2860 -0.131000 -2.14e-01 -1.39e-01 1.34e-01 1.42e-02 1.12e-01
Signaling by TGF-beta Receptor Complex 72 1.61e-03 4.74e-03 0.2860 0.194000 1.23e-01 -1.70e-01 4.39e-03 7.14e-02 1.25e-02
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 18 3.90e-01 4.61e-01 0.2860 0.230000 1.65e-01 3.48e-02 9.06e-02 2.25e-01 7.98e-01
G1/S DNA Damage Checkpoints 65 5.22e-03 1.28e-02 0.2850 0.231000 1.44e-01 -8.54e-02 1.29e-03 4.47e-02 2.34e-01
Selective autophagy 58 2.91e-04 1.06e-03 0.2850 0.216000 5.44e-02 -1.77e-01 4.44e-03 4.73e-01 1.95e-02
FGFR2 mutant receptor activation 22 8.67e-02 1.38e-01 0.2850 0.016600 -1.35e-01 -2.50e-01 8.93e-01 2.72e-01 4.25e-02
Telomere Extension By Telomerase 23 2.86e-01 3.60e-01 0.2850 -0.129000 -1.55e-01 -2.00e-01 2.82e-01 1.97e-01 9.66e-02
APC/C:Cdc20 mediated degradation of mitotic proteins 74 1.27e-03 3.81e-03 0.2840 0.237000 1.34e-01 -8.04e-02 4.17e-04 4.55e-02 2.32e-01
Intracellular signaling by second messengers 271 3.72e-11 5.16e-10 0.2830 0.183000 1.51e-01 -1.55e-01 2.16e-07 1.88e-05 1.11e-05
NOTCH2 intracellular domain regulates transcription 11 5.66e-01 6.28e-01 0.2820 0.160000 2.33e-01 -1.74e-03 3.59e-01 1.81e-01 9.92e-01
Lewis blood group biosynthesis 13 3.33e-01 4.06e-01 0.2820 0.038600 2.88e-02 -2.78e-01 8.09e-01 8.57e-01 8.26e-02
Caspase-mediated cleavage of cytoskeletal proteins 12 3.03e-01 3.75e-01 0.2820 0.098400 1.58e-01 -2.12e-01 5.55e-01 3.43e-01 2.04e-01
Elastic fibre formation 32 1.65e-01 2.33e-01 0.2820 0.203000 1.77e-01 -8.52e-02 4.72e-02 8.40e-02 4.04e-01
Assembly and cell surface presentation of NMDA receptors 18 2.73e-01 3.47e-01 0.2820 -0.112000 -2.31e-01 -1.17e-01 4.12e-01 9.03e-02 3.91e-01
Downregulation of TGF-beta receptor signaling 26 8.76e-02 1.39e-01 0.2820 0.193000 7.86e-02 -1.89e-01 8.79e-02 4.88e-01 9.54e-02
Regulation of RUNX2 expression and activity 66 1.04e-02 2.37e-02 0.2810 0.230000 1.57e-01 -3.67e-02 1.23e-03 2.71e-02 6.07e-01
Chromosome Maintenance 105 5.76e-04 1.94e-03 0.2810 -0.109000 -1.77e-01 -1.88e-01 5.30e-02 1.68e-03 8.69e-04
NOD1/2 Signaling Pathway 32 1.65e-01 2.33e-01 0.2810 0.223000 1.63e-01 4.70e-02 2.87e-02 1.11e-01 6.45e-01
Nucleobase catabolism 28 8.42e-02 1.35e-01 0.2810 0.247000 1.25e-01 -4.55e-02 2.36e-02 2.53e-01 6.77e-01
Mitochondrial calcium ion transport 22 4.53e-02 8.21e-02 0.2800 0.096600 -8.57e-02 -2.49e-01 4.33e-01 4.86e-01 4.32e-02
Elevation of cytosolic Ca2+ levels 12 4.04e-01 4.76e-01 0.2790 0.118000 1.27e-01 -2.19e-01 4.79e-01 4.47e-01 1.89e-01
TNFs bind their physiological receptors 25 2.71e-02 5.28e-02 0.2790 -0.080700 -2.61e-01 -5.75e-02 4.85e-01 2.41e-02 6.19e-01
HS-GAG degradation 16 2.77e-01 3.51e-01 0.2770 0.137000 4.74e-02 -2.36e-01 3.41e-01 7.43e-01 1.02e-01
Phospholipid metabolism 184 1.91e-06 1.28e-05 0.2770 0.183000 1.90e-01 -8.53e-02 1.78e-05 9.01e-06 4.59e-02
Chondroitin sulfate/dermatan sulfate metabolism 38 2.43e-02 4.85e-02 0.2770 0.076300 6.55e-02 -2.58e-01 4.16e-01 4.85e-01 5.96e-03
Depolymerisation of the Nuclear Lamina 15 4.50e-01 5.22e-01 0.2770 0.226000 1.49e-01 5.53e-02 1.30e-01 3.17e-01 7.11e-01
DNA Damage Recognition in GG-NER 38 3.93e-02 7.23e-02 0.2760 -0.012400 -5.41e-02 -2.71e-01 8.95e-01 5.64e-01 3.87e-03
Processing of SMDT1 15 1.44e-01 2.07e-01 0.2760 0.043500 -1.44e-01 -2.32e-01 7.71e-01 3.33e-01 1.21e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 182 5.34e-06 3.14e-05 0.2760 -0.122000 -1.71e-01 -1.79e-01 4.45e-03 7.07e-05 2.99e-05
SUMOylation of chromatin organization proteins 57 1.97e-02 4.03e-02 0.2760 -0.142000 -2.28e-01 -6.52e-02 6.45e-02 2.90e-03 3.95e-01
Ion channel transport 131 4.11e-04 1.46e-03 0.2760 0.198000 1.87e-01 -4.37e-02 9.16e-05 2.11e-04 3.87e-01
Termination of O-glycan biosynthesis 16 2.22e-01 2.95e-01 0.2760 0.039200 5.71e-02 -2.67e-01 7.86e-01 6.92e-01 6.42e-02
Tight junction interactions 18 4.74e-02 8.46e-02 0.2760 0.009230 -2.11e-01 -1.78e-01 9.46e-01 1.22e-01 1.92e-01
p75 NTR receptor-mediated signalling 88 1.70e-03 4.94e-03 0.2750 0.197000 1.47e-01 -1.23e-01 1.37e-03 1.71e-02 4.55e-02
RNA Polymerase I Promoter Escape 47 8.62e-04 2.75e-03 0.2750 0.133000 -4.43e-02 -2.37e-01 1.14e-01 5.99e-01 4.98e-03
Neurexins and neuroligins 36 6.21e-02 1.06e-01 0.2740 -0.045600 -7.89e-02 -2.59e-01 6.36e-01 4.13e-01 7.18e-03
Activation of SMO 13 2.67e-01 3.41e-01 0.2740 0.031000 7.60e-02 -2.62e-01 8.47e-01 6.35e-01 1.02e-01
Integrin cell surface interactions 52 1.91e-02 3.94e-02 0.2740 0.218000 1.29e-01 -1.05e-01 6.65e-03 1.07e-01 1.89e-01
Defects in cobalamin (B12) metabolism 13 4.87e-01 5.54e-01 0.2740 -0.155000 -2.20e-01 4.83e-02 3.32e-01 1.70e-01 7.63e-01
Synthesis of PIPs at the plasma membrane 52 5.34e-03 1.31e-02 0.2740 0.134000 2.25e-01 -7.77e-02 9.42e-02 4.94e-03 3.32e-01
E2F mediated regulation of DNA replication 22 1.31e-01 1.92e-01 0.2730 -0.120000 -1.80e-01 1.66e-01 3.28e-01 1.45e-01 1.78e-01
Signaling by Hedgehog 120 7.68e-05 3.31e-04 0.2720 0.176000 1.36e-01 -1.56e-01 8.64e-04 9.93e-03 3.08e-03
RNA Pol II CTD phosphorylation and interaction with CE 27 4.11e-02 7.51e-02 0.2720 0.134000 -1.94e-02 -2.36e-01 2.28e-01 8.61e-01 3.41e-02
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 27 4.11e-02 7.51e-02 0.2720 0.134000 -1.94e-02 -2.36e-01 2.28e-01 8.61e-01 3.41e-02
Axon guidance 453 2.15e-22 6.37e-21 0.2720 0.121000 3.40e-02 -2.41e-01 9.35e-06 2.15e-01 1.55e-18
GRB2 events in ERBB2 signaling 11 1.57e-01 2.23e-01 0.2710 0.243000 1.77e-02 -1.19e-01 1.63e-01 9.19e-01 4.94e-01
Interconversion of nucleotide di- and triphosphates 27 3.12e-03 8.31e-03 0.2710 0.093900 -1.49e-01 -2.06e-01 3.98e-01 1.79e-01 6.45e-02
NOTCH2 Activation and Transmission of Signal to the Nucleus 20 2.08e-01 2.78e-01 0.2710 0.119000 1.31e-01 -2.05e-01 3.58e-01 3.09e-01 1.13e-01
Binding and Uptake of Ligands by Scavenger Receptors 91 7.67e-16 1.74e-14 0.2700 0.046400 -2.57e-01 -6.86e-02 4.44e-01 2.22e-05 2.58e-01
Ephrin signaling 17 2.90e-01 3.64e-01 0.2700 0.152000 6.73e-02 -2.12e-01 2.77e-01 6.31e-01 1.30e-01
Extracellular matrix organization 216 2.31e-07 1.92e-06 0.2700 0.189000 1.58e-01 -1.10e-01 1.76e-06 5.96e-05 5.34e-03
Constitutive Signaling by NOTCH1 HD Domain Mutants 14 2.34e-01 3.06e-01 0.2690 0.022200 7.45e-02 -2.58e-01 8.86e-01 6.29e-01 9.51e-02
Signaling by NOTCH1 HD Domain Mutants in Cancer 14 2.34e-01 3.06e-01 0.2690 0.022200 7.45e-02 -2.58e-01 8.86e-01 6.29e-01 9.51e-02
HCMV Late Events 69 3.36e-03 8.89e-03 0.2690 0.168000 9.98e-02 -1.85e-01 1.60e-02 1.52e-01 7.81e-03
mRNA Splicing 187 3.24e-10 3.80e-09 0.2690 -0.002930 -1.41e-01 -2.29e-01 9.45e-01 8.54e-04 7.01e-08
Activation of kainate receptors upon glutamate binding 26 2.01e-01 2.71e-01 0.2690 0.169000 1.38e-01 -1.57e-01 1.36e-01 2.23e-01 1.65e-01
Synthesis of bile acids and bile salts 24 3.48e-01 4.20e-01 0.2690 0.141000 2.03e-01 1.05e-01 2.32e-01 8.55e-02 3.71e-01
Formation of HIV elongation complex in the absence of HIV Tat 44 1.62e-02 3.44e-02 0.2680 0.098100 5.14e-03 -2.50e-01 2.60e-01 9.53e-01 4.15e-03
FCGR3A-mediated IL10 synthesis 99 1.70e-08 1.65e-07 0.2680 -0.049500 -2.48e-01 -8.93e-02 3.94e-01 1.98e-05 1.25e-01
Transcriptional regulation by RUNX2 100 4.98e-03 1.24e-02 0.2680 0.193000 1.83e-01 -3.37e-02 8.45e-04 1.56e-03 5.60e-01
Regulation of FOXO transcriptional activity by acetylation 10 5.11e-01 5.77e-01 0.2680 0.115000 1.40e-01 -1.98e-01 5.29e-01 4.45e-01 2.79e-01
Immune System 1888 3.67e-52 2.63e-50 0.2680 0.198000 1.69e-01 -6.64e-02 6.26e-46 6.84e-34 1.82e-06
Laminin interactions 21 1.15e-01 1.73e-01 0.2680 0.242000 8.98e-02 -7.00e-02 5.47e-02 4.76e-01 5.78e-01
NRIF signals cell death from the nucleus 15 2.38e-01 3.12e-01 0.2670 0.212000 6.26e-02 -1.50e-01 1.54e-01 6.74e-01 3.16e-01
Keratan sulfate/keratin metabolism 27 8.22e-02 1.32e-01 0.2670 0.115000 1.72e-01 -1.68e-01 3.01e-01 1.22e-01 1.30e-01
Apoptotic cleavage of cellular proteins 34 2.43e-01 3.17e-01 0.2670 0.174000 2.01e-01 2.27e-02 7.92e-02 4.27e-02 8.19e-01
Triglyceride metabolism 25 4.11e-01 4.83e-01 0.2660 0.188000 1.83e-01 4.93e-02 1.05e-01 1.14e-01 6.70e-01
Metabolism of lipids 620 7.91e-18 2.03e-16 0.2660 0.177000 1.92e-01 -4.70e-02 5.40e-14 2.72e-16 4.56e-02
Downstream signal transduction 27 3.46e-01 4.18e-01 0.2650 0.162000 2.02e-01 5.44e-02 1.44e-01 6.91e-02 6.25e-01
Acyl chain remodelling of PE 20 3.09e-01 3.81e-01 0.2640 0.217000 1.27e-01 -8.13e-02 9.26e-02 3.26e-01 5.29e-01
Nervous system development 472 9.36e-22 2.65e-20 0.2640 0.115000 3.59e-02 -2.35e-01 1.87e-05 1.81e-01 1.97e-18
Peroxisomal lipid metabolism 27 3.52e-01 4.23e-01 0.2640 0.170000 2.00e-01 2.92e-02 1.27e-01 7.16e-02 7.93e-01
Formation of TC-NER Pre-Incision Complex 53 1.15e-03 3.50e-03 0.2630 0.107000 -5.17e-02 -2.35e-01 1.78e-01 5.15e-01 3.13e-03
Hedgehog 'off' state 92 7.40e-04 2.40e-03 0.2630 0.162000 1.06e-01 -1.77e-01 7.06e-03 7.90e-02 3.33e-03
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 27 1.00e-01 1.57e-01 0.2620 0.053500 -5.40e-02 -2.51e-01 6.31e-01 6.27e-01 2.38e-02
NOTCH4 Intracellular Domain Regulates Transcription 17 2.12e-01 2.83e-01 0.2620 0.113000 2.29e-01 -5.42e-02 4.19e-01 1.01e-01 6.99e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER) 78 4.95e-04 1.71e-03 0.2610 -0.009590 -1.37e-01 -2.22e-01 8.84e-01 3.70e-02 6.91e-04
Interleukin-12 signaling 44 1.02e-01 1.58e-01 0.2600 0.207000 1.49e-01 -5.02e-02 1.73e-02 8.68e-02 5.65e-01
Unblocking of NMDA receptors, glutamate binding and activation 12 6.93e-01 7.42e-01 0.2600 -0.201000 -1.63e-01 -2.29e-02 2.28e-01 3.28e-01 8.91e-01
RIPK1-mediated regulated necrosis 16 3.44e-01 4.17e-01 0.2600 0.068100 5.31e-02 2.45e-01 6.37e-01 7.13e-01 9.01e-02
Regulated Necrosis 16 3.44e-01 4.17e-01 0.2600 0.068100 5.31e-02 2.45e-01 6.37e-01 7.13e-01 9.01e-02
Interleukin-6 family signaling 18 5.16e-01 5.80e-01 0.2590 0.205000 1.58e-01 1.77e-02 1.33e-01 2.46e-01 8.97e-01
Downstream signaling of activated FGFR3 16 2.41e-01 3.14e-01 0.2580 0.132000 5.34e-02 2.15e-01 3.61e-01 7.12e-01 1.36e-01
Transport of small molecules 553 1.31e-15 2.93e-14 0.2580 0.192000 1.55e-01 -7.45e-02 1.29e-14 4.41e-10 2.73e-03
Deactivation of the beta-catenin transactivating complex 36 6.11e-02 1.05e-01 0.2570 0.042400 5.48e-03 -2.53e-01 6.59e-01 9.55e-01 8.50e-03
Insulin processing 20 4.41e-01 5.13e-01 0.2570 0.164000 1.39e-01 1.40e-01 2.04e-01 2.80e-01 2.77e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF) 13 4.48e-01 5.20e-01 0.2570 0.130000 2.12e-01 -6.33e-02 4.17e-01 1.85e-01 6.93e-01
Inositol phosphate metabolism 42 9.68e-03 2.21e-02 0.2570 0.088100 1.62e-01 -1.79e-01 3.23e-01 6.92e-02 4.52e-02
FCERI mediated MAPK activation 90 3.42e-12 5.35e-11 0.2570 0.037100 -2.33e-01 -1.01e-01 5.43e-01 1.34e-04 9.63e-02
SUMOylation of DNA damage response and repair proteins 77 2.47e-02 4.93e-02 0.2560 -0.162000 -1.98e-01 -7.10e-03 1.38e-02 2.65e-03 9.14e-01
Nitric oxide stimulates guanylate cyclase 16 2.28e-01 3.01e-01 0.2560 0.238000 8.86e-02 -3.10e-02 9.91e-02 5.40e-01 8.30e-01
ISG15 antiviral mechanism 72 8.17e-03 1.89e-02 0.2550 -0.154000 -1.34e-01 1.54e-01 2.43e-02 4.88e-02 2.42e-02
Transport of Mature Transcript to Cytoplasm 81 7.91e-03 1.84e-02 0.2550 -0.137000 -2.11e-01 -3.92e-02 3.31e-02 1.00e-03 5.42e-01
HATs acetylate histones 93 6.38e-04 2.14e-03 0.2540 -0.018500 -5.13e-02 -2.49e-01 7.57e-01 3.93e-01 3.42e-05
Interleukin-12 family signaling 53 5.92e-02 1.02e-01 0.2540 0.211000 1.43e-01 7.36e-04 7.99e-03 7.22e-02 9.93e-01
Peroxisomal protein import 57 8.25e-02 1.32e-01 0.2540 0.181000 1.74e-01 -3.84e-02 1.82e-02 2.28e-02 6.16e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter 28 3.45e-01 4.17e-01 0.2540 -0.128000 -1.72e-01 -1.36e-01 2.39e-01 1.16e-01 2.12e-01
Pyruvate metabolism and Citric Acid (TCA) cycle 52 9.05e-02 1.43e-01 0.2540 0.200000 1.54e-01 -3.01e-02 1.28e-02 5.54e-02 7.08e-01
PI-3K cascade:FGFR1 12 5.96e-01 6.54e-01 0.2530 0.086700 9.97e-02 2.16e-01 6.03e-01 5.50e-01 1.94e-01
IRF3-mediated induction of type I IFN 12 5.61e-01 6.25e-01 0.2530 -0.036000 -1.15e-01 -2.22e-01 8.29e-01 4.91e-01 1.83e-01
Platelet calcium homeostasis 21 2.95e-01 3.69e-01 0.2520 0.138000 1.92e-01 -8.90e-02 2.74e-01 1.28e-01 4.80e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 11 4.82e-01 5.50e-01 0.2520 0.041300 -7.72e-02 -2.36e-01 8.12e-01 6.57e-01 1.75e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1 11 5.51e-01 6.16e-01 0.2510 -0.021500 -1.27e-01 -2.16e-01 9.02e-01 4.64e-01 2.16e-01
Signaling by TGFB family members 91 1.68e-03 4.92e-03 0.2510 0.183000 1.07e-01 -1.34e-01 2.49e-03 7.90e-02 2.70e-02
Dual incision in TC-NER 65 2.74e-03 7.43e-03 0.2510 -0.020900 -1.52e-01 -1.99e-01 7.71e-01 3.44e-02 5.58e-03
Neurotransmitter receptors and postsynaptic signal transmission 123 1.12e-03 3.42e-03 0.2500 0.167000 1.68e-01 -8.13e-02 1.40e-03 1.30e-03 1.19e-01
Interferon Signaling 177 1.83e-08 1.75e-07 0.2500 -0.157000 -4.09e-02 1.90e-01 3.07e-04 3.48e-01 1.26e-05
Rho GTPase cycle 125 1.19e-03 3.61e-03 0.2490 0.158000 1.90e-01 -3.66e-02 2.31e-03 2.50e-04 4.80e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 80 1.37e-02 2.99e-02 0.2490 0.170000 1.52e-01 -1.00e-01 8.46e-03 1.86e-02 1.22e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation 11 4.53e-01 5.25e-01 0.2490 -0.080500 4.83e-02 2.31e-01 6.44e-01 7.81e-01 1.85e-01
Regulation of KIT signaling 15 3.05e-01 3.77e-01 0.2490 0.095500 1.64e-01 -1.61e-01 5.22e-01 2.71e-01 2.80e-01
Serotonin Neurotransmitter Release Cycle 14 5.10e-01 5.76e-01 0.2490 -0.039900 -7.72e-02 -2.33e-01 7.96e-01 6.17e-01 1.31e-01
Interleukin receptor SHC signaling 23 9.91e-02 1.55e-01 0.2490 0.096700 2.24e-01 -4.98e-02 4.22e-01 6.32e-02 6.79e-01
Unfolded Protein Response (UPR) 86 4.53e-03 1.14e-02 0.2480 0.182000 1.18e-01 -1.22e-01 3.56e-03 5.89e-02 5.15e-02
NoRC negatively regulates rRNA expression 62 1.87e-03 5.34e-03 0.2480 0.139000 7.52e-03 -2.06e-01 5.89e-02 9.18e-01 5.07e-03
Endosomal/Vacuolar pathway 12 5.53e-01 6.18e-01 0.2470 -0.098700 -7.67e-02 -2.13e-01 5.54e-01 6.46e-01 2.01e-01
Developmental Biology 725 1.91e-26 6.18e-25 0.2460 0.137000 7.53e-02 -1.90e-01 3.16e-10 5.54e-04 2.65e-18
Protein localization 157 2.22e-07 1.87e-06 0.2460 0.115000 3.73e-03 -2.17e-01 1.27e-02 9.36e-01 2.68e-06
Processing of Capped Intron-Containing Pre-mRNA 238 2.01e-10 2.46e-09 0.2450 -0.037400 -1.66e-01 -1.77e-01 3.20e-01 1.07e-05 2.53e-06
O-linked glycosylation of mucins 47 5.70e-02 9.92e-02 0.2450 0.133000 2.03e-01 -3.48e-02 1.14e-01 1.61e-02 6.80e-01
Factors involved in megakaryocyte development and platelet production 115 8.16e-03 1.89e-02 0.2450 0.181000 1.66e-01 -5.28e-03 8.16e-04 2.17e-03 9.22e-01
Pregnenolone biosynthesis 10 5.16e-01 5.79e-01 0.2450 0.061600 9.70e-02 -2.16e-01 7.36e-01 5.95e-01 2.36e-01
Ras activation upon Ca2+ influx through NMDA receptor 15 5.61e-01 6.25e-01 0.2450 -0.124000 -2.02e-01 -5.99e-02 4.05e-01 1.75e-01 6.88e-01
Transcription of E2F targets under negative control by DREAM complex 19 5.21e-02 9.15e-02 0.2440 0.010300 -2.04e-01 -1.34e-01 9.38e-01 1.24e-01 3.10e-01
Regulation of Complement cascade 94 5.14e-11 6.92e-10 0.2440 -0.007770 -2.43e-01 -1.50e-02 8.96e-01 4.52e-05 8.02e-01
TRP channels 17 2.47e-01 3.21e-01 0.2440 -0.067700 7.12e-02 2.23e-01 6.29e-01 6.11e-01 1.11e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 19 1.36e-01 1.98e-01 0.2430 -0.080700 -2.29e-01 1.03e-02 5.42e-01 8.36e-02 9.38e-01
SHC-mediated cascade:FGFR2 12 4.02e-01 4.74e-01 0.2430 -0.049200 -9.83e-02 2.17e-01 7.68e-01 5.55e-01 1.93e-01
Assembly of the pre-replicative complex 66 1.54e-02 3.29e-02 0.2430 0.191000 1.07e-01 -1.06e-01 7.37e-03 1.33e-01 1.37e-01
G alpha (12/13) signalling events 68 4.58e-02 8.24e-02 0.2420 0.159000 1.75e-01 -5.14e-02 2.31e-02 1.24e-02 4.64e-01
RNA Polymerase II Transcription Termination 65 2.09e-03 5.88e-03 0.2420 -0.030300 -1.74e-01 -1.66e-01 6.72e-01 1.54e-02 2.10e-02
RAF-independent MAPK1/3 activation 21 3.64e-01 4.34e-01 0.2420 0.140000 1.22e-01 -1.55e-01 2.66e-01 3.32e-01 2.20e-01
Complement cascade 98 5.88e-11 7.77e-10 0.2420 -0.007750 -2.40e-01 -2.80e-02 8.95e-01 4.06e-05 6.31e-01
Signaling by WNT in cancer 30 4.57e-02 8.24e-02 0.2420 0.083100 1.80e-01 -1.38e-01 4.31e-01 8.77e-02 1.92e-01
Mitochondrial biogenesis 88 5.20e-04 1.78e-03 0.2410 0.165000 5.32e-02 -1.68e-01 7.62e-03 3.89e-01 6.38e-03
Cohesin Loading onto Chromatin 10 4.70e-01 5.41e-01 0.2410 0.189000 7.29e-02 1.30e-01 3.00e-01 6.90e-01 4.76e-01
Synthesis of PIPs at the early endosome membrane 16 3.62e-01 4.33e-01 0.2410 -0.011800 1.05e-01 2.16e-01 9.35e-01 4.69e-01 1.34e-01
Signaling by FGFR3 in disease 13 1.98e-01 2.69e-01 0.2400 0.014200 -9.85e-02 2.18e-01 9.29e-01 5.39e-01 1.73e-01
Signaling by FGFR3 point mutants in cancer 13 1.98e-01 2.69e-01 0.2400 0.014200 -9.85e-02 2.18e-01 9.29e-01 5.39e-01 1.73e-01
RAS processing 19 2.70e-01 3.45e-01 0.2400 0.124000 1.37e-02 -2.05e-01 3.51e-01 9.18e-01 1.22e-01
Infectious disease 723 7.79e-32 3.03e-30 0.2400 0.119000 4.61e-03 -2.08e-01 5.62e-08 8.33e-01 1.51e-21
Sulfur amino acid metabolism 22 2.77e-01 3.51e-01 0.2390 0.036400 -8.08e-03 -2.37e-01 7.68e-01 9.48e-01 5.47e-02
Stimuli-sensing channels 71 6.45e-02 1.09e-01 0.2390 0.184000 1.52e-01 2.67e-03 7.18e-03 2.71e-02 9.69e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 17 3.30e-01 4.03e-01 0.2390 0.141000 3.14e-02 -1.90e-01 3.15e-01 8.23e-01 1.74e-01
Defective B3GAT3 causes JDSSDHD 11 6.02e-01 6.60e-01 0.2390 -0.009070 -9.69e-02 -2.18e-01 9.58e-01 5.78e-01 2.10e-01
Metabolism of cofactors 19 5.55e-01 6.19e-01 0.2380 0.188000 1.42e-01 3.27e-02 1.56e-01 2.83e-01 8.05e-01
MAPK1/MAPK3 signaling 234 1.90e-06 1.28e-05 0.2380 0.168000 1.32e-01 -1.05e-01 9.91e-06 5.09e-04 5.45e-03
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 10 6.08e-01 6.64e-01 0.2380 -0.078100 2.70e-03 2.25e-01 6.69e-01 9.88e-01 2.19e-01
Formation of RNA Pol II elongation complex 57 2.53e-02 5.00e-02 0.2380 0.148000 7.53e-02 -1.70e-01 5.34e-02 3.25e-01 2.63e-02
RNA Polymerase II Transcription Elongation 57 2.53e-02 5.00e-02 0.2380 0.148000 7.53e-02 -1.70e-01 5.34e-02 3.25e-01 2.63e-02
Meiotic synapsis 45 1.20e-01 1.79e-01 0.2380 0.173000 1.25e-01 -1.05e-01 4.51e-02 1.48e-01 2.21e-01
Synthesis of very long-chain fatty acyl-CoAs 21 4.20e-01 4.93e-01 0.2380 0.201000 1.26e-01 1.07e-03 1.11e-01 3.16e-01 9.93e-01
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 38 1.69e-01 2.37e-01 0.2370 -0.111000 -1.93e-01 -8.14e-02 2.36e-01 3.94e-02 3.85e-01
CD209 (DC-SIGN) signaling 20 5.00e-01 5.68e-01 0.2370 0.183000 1.35e-01 -6.54e-02 1.55e-01 2.97e-01 6.13e-01
Circadian Clock 67 4.66e-02 8.37e-02 0.2370 0.171000 1.38e-01 -8.81e-02 1.52e-02 5.16e-02 2.12e-01
NCAM1 interactions 23 5.55e-01 6.19e-01 0.2370 -0.165000 -1.62e-01 -4.86e-02 1.70e-01 1.78e-01 6.87e-01
FLT3 Signaling 243 1.13e-06 8.28e-06 0.2360 0.161000 1.32e-01 -1.12e-01 1.56e-05 4.10e-04 2.68e-03
Negative epigenetic regulation of rRNA expression 65 2.40e-03 6.61e-03 0.2350 0.102000 -2.60e-02 -2.10e-01 1.56e-01 7.17e-01 3.34e-03
G1/S-Specific Transcription 29 6.37e-02 1.08e-01 0.2340 -0.085700 -2.17e-01 2.03e-02 4.24e-01 4.28e-02 8.50e-01
Transcriptional Regulation by MECP2 47 8.56e-02 1.37e-01 0.2340 0.145000 1.06e-01 -1.50e-01 8.51e-02 2.07e-01 7.62e-02
Establishment of Sister Chromatid Cohesion 11 2.41e-01 3.14e-01 0.2340 0.059400 -6.92e-02 2.15e-01 7.33e-01 6.91e-01 2.16e-01
DAG and IP3 signaling 33 1.65e-01 2.33e-01 0.2340 0.121000 1.27e-01 -1.55e-01 2.31e-01 2.06e-01 1.24e-01
Lysine catabolism 11 7.01e-01 7.50e-01 0.2340 0.082300 1.62e-01 1.47e-01 6.36e-01 3.53e-01 3.99e-01
Regulation of MECP2 expression and activity 28 2.71e-01 3.45e-01 0.2330 0.135000 1.27e-01 -1.41e-01 2.15e-01 2.45e-01 1.96e-01
Deubiquitination 241 3.04e-05 1.47e-04 0.2320 0.174000 1.50e-01 -3.32e-02 3.26e-06 6.00e-05 3.75e-01
Cell junction organization 57 3.32e-02 6.26e-02 0.2320 0.163000 8.47e-02 -1.42e-01 3.35e-02 2.69e-01 6.35e-02
Transcriptional regulation by RUNX1 184 3.59e-05 1.70e-04 0.2320 0.152000 1.25e-01 -1.23e-01 3.65e-04 3.57e-03 4.02e-03
Regulation of APC/C activators between G1/S and early anaphase 79 2.05e-03 5.82e-03 0.2310 0.199000 8.19e-02 -8.36e-02 2.18e-03 2.08e-01 1.99e-01
Phase 4 - resting membrane potential 10 8.22e-01 8.51e-01 0.2310 0.132000 1.61e-01 1.01e-01 4.68e-01 3.79e-01 5.82e-01
Signaling by NOTCH2 30 1.91e-01 2.60e-01 0.2310 0.117000 1.50e-01 -1.30e-01 2.66e-01 1.54e-01 2.16e-01
RAF/MAP kinase cascade 229 4.20e-06 2.59e-05 0.2310 0.158000 1.26e-01 -1.12e-01 3.81e-05 1.00e-03 3.63e-03
Nucleotide Excision Repair 110 3.87e-04 1.38e-03 0.2310 -0.011000 -1.11e-01 -2.02e-01 8.42e-01 4.35e-02 2.57e-04
Cell-Cell communication 85 6.47e-03 1.53e-02 0.2290 0.144000 8.42e-02 -1.57e-01 2.20e-02 1.80e-01 1.21e-02
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 12 5.88e-01 6.47e-01 0.2290 0.180000 8.42e-02 -1.13e-01 2.79e-01 6.13e-01 4.96e-01
Regulation of RUNX1 Expression and Activity 18 3.61e-01 4.32e-01 0.2290 -0.070200 2.26e-02 2.17e-01 6.06e-01 8.68e-01 1.12e-01
Intrinsic Pathway for Apoptosis 52 1.34e-01 1.96e-01 0.2290 0.179000 1.33e-01 -5.09e-02 2.55e-02 9.73e-02 5.25e-01
Muscle contraction 140 3.67e-03 9.62e-03 0.2280 0.152000 1.69e-01 -2.10e-02 1.96e-03 5.47e-04 6.68e-01
mRNA decay by 5' to 3' exoribonuclease 15 5.14e-01 5.79e-01 0.2280 -0.015300 -1.02e-01 -2.03e-01 9.18e-01 4.95e-01 1.73e-01
Glutathione conjugation 26 4.77e-01 5.46e-01 0.2280 0.179000 1.41e-01 6.76e-03 1.15e-01 2.13e-01 9.52e-01
Retrograde transport at the Trans-Golgi-Network 49 2.12e-01 2.83e-01 0.2260 0.174000 1.44e-01 -9.10e-03 3.52e-02 8.01e-02 9.12e-01
VEGFR2 mediated cell proliferation 18 6.02e-01 6.60e-01 0.2260 0.168000 1.37e-01 -6.60e-02 2.18e-01 3.15e-01 6.28e-01
HCMV Infection 96 2.58e-03 7.04e-03 0.2260 0.148000 7.38e-02 -1.54e-01 1.20e-02 2.11e-01 9.17e-03
RNA Polymerase III Transcription Termination 23 2.46e-01 3.20e-01 0.2260 -0.041800 -1.66e-01 -1.48e-01 7.28e-01 1.68e-01 2.20e-01
TRAF3-dependent IRF activation pathway 13 6.03e-01 6.60e-01 0.2260 0.045600 1.38e-01 1.73e-01 7.76e-01 3.91e-01 2.80e-01
Fertilization 12 5.72e-01 6.33e-01 0.2260 0.084700 4.09e-03 -2.09e-01 6.11e-01 9.80e-01 2.10e-01
Dopamine Neurotransmitter Release Cycle 19 4.69e-01 5.40e-01 0.2250 -0.041200 -1.14e-01 -1.90e-01 7.56e-01 3.89e-01 1.52e-01
Ub-specific processing proteases 170 5.84e-04 1.97e-03 0.2250 0.181000 1.32e-01 -2.52e-02 4.64e-05 3.06e-03 5.71e-01
Interleukin-7 signaling 21 3.45e-01 4.17e-01 0.2250 0.073500 5.25e-02 -2.06e-01 5.60e-01 6.77e-01 1.02e-01
Signal Transduction 1870 2.51e-39 1.10e-37 0.2250 0.153000 1.44e-01 -8.08e-02 5.38e-28 6.23e-25 7.22e-09
Other interleukin signaling 18 3.03e-01 3.75e-01 0.2250 0.056200 9.91e-02 -1.94e-01 6.80e-01 4.67e-01 1.54e-01
Signaling by ERBB2 in Cancer 21 1.29e-01 1.91e-01 0.2250 0.217000 5.90e-02 -1.20e-02 8.55e-02 6.40e-01 9.24e-01
SUMOylation of DNA replication proteins 46 1.96e-01 2.66e-01 0.2250 -0.145000 -1.67e-01 4.01e-02 8.80e-02 5.03e-02 6.38e-01
Signaling by ERBB2 44 1.52e-01 2.18e-01 0.2250 0.164000 1.12e-01 -1.06e-01 6.05e-02 1.97e-01 2.25e-01
Regulation of beta-cell development 19 4.78e-01 5.47e-01 0.2250 0.129000 1.31e-01 -1.29e-01 3.31e-01 3.21e-01 3.30e-01
Cytosolic sulfonation of small molecules 19 5.63e-01 6.25e-01 0.2250 0.144000 1.60e-01 -6.31e-02 2.76e-01 2.26e-01 6.34e-01
Chromatin modifying enzymes 217 1.09e-07 9.65e-07 0.2240 0.047200 3.67e-02 -2.16e-01 2.31e-01 3.51e-01 4.09e-08
Chromatin organization 217 1.09e-07 9.65e-07 0.2240 0.047200 3.67e-02 -2.16e-01 2.31e-01 3.51e-01 4.09e-08
MAPK family signaling cascades 267 1.69e-06 1.17e-05 0.2240 0.166000 1.22e-01 -8.85e-02 2.91e-06 6.28e-04 1.28e-02
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 10 5.14e-01 5.78e-01 0.2240 0.134000 -7.29e-03 -1.79e-01 4.62e-01 9.68e-01 3.27e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 46 7.04e-02 1.16e-01 0.2240 0.091300 8.31e-02 -1.87e-01 2.84e-01 3.29e-01 2.85e-02
Regulation of innate immune responses to cytosolic DNA 14 4.85e-01 5.53e-01 0.2230 0.015600 -9.39e-02 -2.02e-01 9.19e-01 5.43e-01 1.91e-01
Cellular response to heat stress 93 8.55e-03 1.96e-02 0.2230 -0.069900 -1.54e-01 -1.46e-01 2.44e-01 1.04e-02 1.52e-02
CD28 dependent Vav1 pathway 12 7.43e-01 7.86e-01 0.2230 0.170000 1.29e-01 -6.43e-02 3.07e-01 4.39e-01 7.00e-01
Signaling by PDGF 44 2.32e-01 3.05e-01 0.2230 0.147000 1.63e-01 -3.94e-02 9.20e-02 6.18e-02 6.51e-01
Metabolism of nucleotides 86 4.64e-05 2.14e-04 0.2230 0.109000 -5.39e-02 -1.87e-01 8.10e-02 3.88e-01 2.78e-03
Blood group systems biosynthesis 17 3.48e-01 4.20e-01 0.2230 0.151000 3.01e-02 -1.61e-01 2.82e-01 8.30e-01 2.50e-01
Transport of vitamins, nucleosides, and related molecules 33 3.37e-01 4.09e-01 0.2230 0.152000 1.44e-01 -7.49e-02 1.31e-01 1.51e-01 4.56e-01
Class I MHC mediated antigen processing & presentation 348 6.94e-07 5.43e-06 0.2220 0.169000 1.41e-01 -3.18e-02 6.31e-08 6.59e-06 3.08e-01
Nephrin family interactions 17 5.34e-01 5.99e-01 0.2220 -0.061700 -7.29e-02 -2.00e-01 6.59e-01 6.03e-01 1.53e-01
Fatty acid metabolism 151 1.84e-03 5.28e-03 0.2220 0.150000 1.50e-01 -6.49e-02 1.48e-03 1.48e-03 1.69e-01
Negative regulation of the PI3K/AKT network 87 1.65e-02 3.49e-02 0.2210 0.137000 1.26e-01 -1.19e-01 2.70e-02 4.19e-02 5.46e-02
FOXO-mediated transcription 58 5.81e-02 1.01e-01 0.2210 0.134000 9.40e-02 -1.49e-01 7.84e-02 2.15e-01 4.94e-02
MECP2 regulates neuronal receptors and channels 13 5.99e-01 6.57e-01 0.2210 0.106000 5.72e-02 -1.85e-01 5.07e-01 7.21e-01 2.48e-01
Diseases associated with O-glycosylation of proteins 48 1.50e-02 3.21e-02 0.2200 -0.203000 -7.41e-02 -4.29e-02 1.51e-02 3.75e-01 6.07e-01
Transcriptional regulation by small RNAs 63 1.09e-02 2.47e-02 0.2200 0.073900 -3.10e-02 -2.05e-01 3.11e-01 6.70e-01 4.95e-03
Adrenaline,noradrenaline inhibits insulin secretion 24 4.71e-01 5.41e-01 0.2200 0.138000 1.62e-01 -5.46e-02 2.43e-01 1.69e-01 6.44e-01
FCERI mediated NF-kB activation 137 6.25e-14 1.18e-12 0.2190 0.122000 -1.19e-01 -1.39e-01 1.39e-02 1.66e-02 4.98e-03
TNFR2 non-canonical NF-kB pathway 95 1.21e-04 4.90e-04 0.2190 0.160000 2.06e-02 -1.48e-01 6.98e-03 7.29e-01 1.27e-02
Interleukin-37 signaling 19 1.97e-01 2.68e-01 0.2190 0.058900 2.07e-01 3.59e-02 6.57e-01 1.18e-01 7.87e-01
Metabolism 1756 1.05e-45 5.48e-44 0.2180 0.137000 8.09e-02 -1.50e-01 1.82e-21 1.82e-08 2.23e-25
Antigen Presentation: Folding, assembly and peptide loading of class I MHC 25 5.13e-01 5.78e-01 0.2170 0.123000 1.72e-01 4.53e-02 2.86e-01 1.36e-01 6.95e-01
Protein methylation 15 1.79e-01 2.48e-01 0.2160 0.126000 -6.70e-02 -1.62e-01 4.00e-01 6.53e-01 2.76e-01
Cell death signalling via NRAGE, NRIF and NADE 69 6.02e-02 1.04e-01 0.2140 0.140000 1.17e-01 -1.11e-01 4.37e-02 9.19e-02 1.10e-01
APC/C-mediated degradation of cell cycle proteins 86 6.90e-03 1.62e-02 0.2140 0.187000 9.06e-02 -5.28e-02 2.78e-03 1.46e-01 3.97e-01
Regulation of mitotic cell cycle 86 6.90e-03 1.62e-02 0.2140 0.187000 9.06e-02 -5.28e-02 2.78e-03 1.46e-01 3.97e-01
G alpha (s) signalling events 140 6.96e-04 2.28e-03 0.2140 0.067800 1.56e-01 1.30e-01 1.66e-01 1.44e-03 8.14e-03
PI-3K cascade:FGFR2 12 4.74e-01 5.43e-01 0.2130 -0.061300 -1.35e-01 1.53e-01 7.13e-01 4.19e-01 3.57e-01
Defective B4GALT7 causes EDS, progeroid type 11 7.02e-01 7.50e-01 0.2130 -0.044600 -1.34e-01 -1.59e-01 7.98e-01 4.41e-01 3.61e-01
Cyclin E associated events during G1/S transition 83 1.21e-02 2.70e-02 0.2120 0.173000 8.63e-02 -8.62e-02 6.40e-03 1.74e-01 1.75e-01
PI Metabolism 79 6.25e-03 1.49e-02 0.2110 0.098400 1.68e-01 -8.21e-02 1.30e-01 9.84e-03 2.07e-01
Disorders of transmembrane transporters 145 2.86e-04 1.05e-03 0.2110 0.150000 7.24e-02 -1.30e-01 1.87e-03 1.33e-01 7.11e-03
Neddylation 218 1.70e-05 8.82e-05 0.2100 0.158000 9.34e-02 -1.01e-01 5.54e-05 1.75e-02 9.94e-03
FRS-mediated FGFR4 signaling 12 3.12e-01 3.84e-01 0.2100 0.154000 1.61e-02 1.42e-01 3.56e-01 9.23e-01 3.95e-01
Vitamin B5 (pantothenate) metabolism 17 6.93e-01 7.42e-01 0.2100 0.143000 1.20e-01 9.59e-02 3.08e-01 3.93e-01 4.94e-01
Regulation of HSF1-mediated heat shock response 79 3.22e-02 6.10e-02 0.2090 -0.081200 -1.63e-01 -1.02e-01 2.12e-01 1.21e-02 1.17e-01
Synthesis of IP2, IP, and Ins in the cytosol 13 6.83e-01 7.34e-01 0.2080 0.087300 1.72e-01 7.82e-02 5.86e-01 2.83e-01 6.26e-01
Post-translational protein modification 1188 2.90e-21 8.05e-20 0.2080 0.150000 1.28e-01 -6.57e-02 2.61e-18 1.14e-13 1.37e-04
Interleukin-2 family signaling 38 1.10e-01 1.68e-01 0.2080 0.090400 1.87e-01 -1.34e-02 3.35e-01 4.63e-02 8.86e-01
Keratan sulfate biosynthesis 22 1.09e-01 1.67e-01 0.2070 -0.016200 8.52e-02 -1.88e-01 8.95e-01 4.89e-01 1.27e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 36 1.52e-01 2.18e-01 0.2070 0.085200 1.19e-01 -1.46e-01 3.76e-01 2.16e-01 1.30e-01
ADORA2B mediated anti-inflammatory cytokines production 73 1.05e-02 2.40e-02 0.2060 0.072600 1.06e-01 -1.61e-01 2.83e-01 1.17e-01 1.74e-02
PI3K/AKT Signaling in Cancer 80 2.52e-02 4.99e-02 0.2060 0.108000 9.02e-02 -1.50e-01 9.55e-02 1.63e-01 2.04e-02
Cobalamin (Cbl, vitamin B12) transport and metabolism 16 6.76e-01 7.28e-01 0.2050 -0.128000 -1.44e-01 7.05e-02 3.75e-01 3.18e-01 6.25e-01
Cyclin A/B1/B2 associated events during G2/M transition 24 3.29e-01 4.03e-01 0.2050 0.118000 6.27e-02 1.56e-01 3.17e-01 5.95e-01 1.86e-01
DNA Double Strand Break Response 47 1.02e-01 1.58e-01 0.2040 0.078800 8.11e-02 -1.70e-01 3.50e-01 3.36e-01 4.38e-02
Synthesis of substrates in N-glycan biosythesis 58 9.87e-02 1.55e-01 0.2040 0.127000 8.82e-02 -1.33e-01 9.50e-02 2.45e-01 7.94e-02
FRS-mediated FGFR2 signaling 14 3.51e-01 4.23e-01 0.2040 0.009380 -7.21e-02 1.90e-01 9.52e-01 6.41e-01 2.17e-01
DNA Damage Bypass 47 1.24e-01 1.84e-01 0.2030 -0.094500 -1.78e-01 -2.43e-02 2.63e-01 3.43e-02 7.73e-01
Signaling by ERBB2 ECD mutants 15 5.80e-01 6.40e-01 0.2030 0.154000 8.34e-02 1.03e-01 3.03e-01 5.76e-01 4.88e-01
Cholesterol biosynthesis 24 3.57e-01 4.28e-01 0.2030 0.090800 1.81e-01 1.34e-02 4.41e-01 1.25e-01 9.09e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 16 2.95e-01 3.69e-01 0.2030 -0.029700 -1.84e-01 -8.02e-02 8.37e-01 2.03e-01 5.79e-01
Host Interactions of HIV factors 129 2.46e-04 9.19e-04 0.2030 0.083200 -1.14e-02 -1.84e-01 1.03e-01 8.23e-01 2.96e-04
Regulation of necroptotic cell death 14 4.55e-01 5.27e-01 0.2020 -0.015200 -6.66e-02 1.91e-01 9.22e-01 6.66e-01 2.17e-01
Activation of BH3-only proteins 29 3.33e-01 4.06e-01 0.2020 0.114000 6.28e-02 -1.55e-01 2.89e-01 5.59e-01 1.48e-01
Fatty acyl-CoA biosynthesis 33 4.30e-01 5.03e-01 0.2020 0.144000 1.25e-01 -6.77e-02 1.52e-01 2.16e-01 5.01e-01
Transmission across Chemical Synapses 169 3.08e-03 8.22e-03 0.2020 0.135000 1.40e-01 -5.50e-02 2.41e-03 1.75e-03 2.17e-01
RUNX2 regulates bone development 23 4.76e-02 8.47e-02 0.2020 0.008780 1.99e-01 3.34e-02 9.42e-01 9.86e-02 7.81e-01
Signaling by FGFR2 60 3.63e-02 6.76e-02 0.2020 0.099700 1.21e-02 -1.75e-01 1.81e-01 8.71e-01 1.90e-02
Potassium Channels 62 1.69e-01 2.37e-01 0.2010 0.124000 1.58e-01 -7.13e-03 9.00e-02 3.14e-02 9.23e-01
Signaling by ERBB2 TMD/JMD mutants 17 1.89e-01 2.58e-01 0.2010 0.191000 1.68e-02 -6.19e-02 1.74e-01 9.05e-01 6.59e-01
Signaling by NTRK2 (TRKB) 20 5.71e-01 6.32e-01 0.2010 0.148000 9.89e-02 9.27e-02 2.51e-01 4.44e-01 4.73e-01
Leishmania infection 245 7.50e-07 5.83e-06 0.2010 0.157000 6.83e-02 -1.05e-01 2.28e-05 6.54e-02 4.72e-03
Protein-protein interactions at synapses 56 6.64e-02 1.12e-01 0.2010 0.020200 5.66e-03 -2.00e-01 7.94e-01 9.42e-01 9.72e-03
Disease 1292 1.39e-31 5.10e-30 0.2010 0.125000 5.85e-02 -1.46e-01 3.77e-14 4.12e-04 1.51e-18
Adherens junctions interactions 16 2.40e-01 3.13e-01 0.2010 0.047300 1.92e-01 -3.56e-02 7.43e-01 1.84e-01 8.05e-01
Nicotinamide salvaging 14 5.08e-01 5.76e-01 0.2000 -0.104000 9.22e-03 1.71e-01 5.00e-01 9.52e-01 2.69e-01
HIV Infection 224 1.69e-06 1.17e-05 0.2000 0.129000 4.28e-02 -1.46e-01 9.08e-04 2.70e-01 1.59e-04
Aflatoxin activation and detoxification 14 6.20e-01 6.74e-01 0.1990 0.159000 7.00e-02 -9.70e-02 3.02e-01 6.50e-01 5.30e-01
SHC-mediated cascade:FGFR4 10 4.80e-01 5.48e-01 0.1990 0.113000 2.26e-03 1.64e-01 5.38e-01 9.90e-01 3.69e-01
Insulin receptor signalling cascade 39 3.82e-01 4.52e-01 0.1990 0.160000 1.17e-01 1.15e-03 8.33e-02 2.05e-01 9.90e-01
Voltage gated Potassium channels 24 2.26e-01 3.00e-01 0.1980 0.036700 9.38e-02 -1.71e-01 7.56e-01 4.27e-01 1.47e-01
Regulation of actin dynamics for phagocytic cup formation 123 1.32e-07 1.16e-06 0.1980 0.178000 3.56e-04 -8.75e-02 6.56e-04 9.95e-01 9.39e-02
Cyclin A:Cdk2-associated events at S phase entry 85 1.86e-02 3.85e-02 0.1970 0.157000 7.42e-02 -9.35e-02 1.25e-02 2.37e-01 1.36e-01
TP53 Regulates Transcription of Death Receptors and Ligands 11 4.31e-01 5.03e-01 0.1960 0.156000 -8.87e-03 -1.19e-01 3.69e-01 9.59e-01 4.95e-01
Downstream signaling of activated FGFR2 19 2.96e-01 3.70e-01 0.1960 0.013300 -5.05e-02 1.89e-01 9.20e-01 7.03e-01 1.53e-01
PECAM1 interactions 12 1.91e-01 2.60e-01 0.1960 -0.005780 1.73e-01 -9.16e-02 9.72e-01 2.98e-01 5.83e-01
Interferon gamma signaling 83 1.50e-03 4.42e-03 0.1960 -0.148000 -1.59e-02 1.28e-01 1.98e-02 8.02e-01 4.41e-02
mRNA Capping 29 1.09e-01 1.67e-01 0.1960 0.084700 -6.15e-02 -1.66e-01 4.30e-01 5.67e-01 1.23e-01
ECM proteoglycans 35 4.61e-01 5.32e-01 0.1940 0.117000 1.54e-01 1.26e-02 2.31e-01 1.15e-01 8.97e-01
Downstream signaling of activated FGFR4 17 2.98e-01 3.71e-01 0.1940 0.116000 1.43e-02 1.55e-01 4.09e-01 9.19e-01 2.70e-01
Metabolism of proteins 1710 1.08e-40 5.25e-39 0.1930 0.128000 5.06e-02 -1.35e-01 1.04e-18 5.10e-04 1.23e-20
Acyl chain remodelling of PS 14 6.85e-01 7.36e-01 0.1930 0.134000 6.98e-02 -1.20e-01 3.84e-01 6.51e-01 4.38e-01
Deadenylation of mRNA 22 1.63e-02 3.45e-02 0.1930 0.152000 -5.27e-02 1.07e-01 2.17e-01 6.69e-01 3.86e-01
Phase 0 - rapid depolarisation 28 3.28e-01 4.01e-01 0.1930 -0.163000 -7.05e-02 7.52e-02 1.36e-01 5.19e-01 4.91e-01
Synthesis, secretion, and deacylation of Ghrelin 11 6.53e-01 7.06e-01 0.1920 -0.068900 -1.77e-01 -3.23e-02 6.92e-01 3.10e-01 8.53e-01
Downstream TCR signaling 100 2.59e-03 7.07e-03 0.1920 0.076300 -2.31e-02 -1.75e-01 1.87e-01 6.90e-01 2.54e-03
Signaling by NODAL 13 5.92e-01 6.51e-01 0.1910 -0.046500 -6.41e-03 -1.85e-01 7.71e-01 9.68e-01 2.47e-01
Regulation of TP53 Expression and Degradation 36 3.08e-01 3.80e-01 0.1910 -0.018400 -7.37e-02 -1.75e-01 8.48e-01 4.44e-01 6.91e-02
Neuronal System 253 5.07e-05 2.28e-04 0.1910 0.113000 1.26e-01 -8.81e-02 1.93e-03 5.72e-04 1.59e-02
Global Genome Nucleotide Excision Repair (GG-NER) 84 3.08e-02 5.90e-02 0.1910 -0.046800 -1.33e-01 -1.29e-01 4.58e-01 3.54e-02 4.17e-02
Signaling by the B Cell Receptor (BCR) 162 1.32e-09 1.45e-08 0.1900 0.097800 -8.14e-02 -1.42e-01 3.17e-02 7.40e-02 1.85e-03
G alpha (q) signalling events 130 2.11e-03 5.93e-03 0.1900 0.091600 1.23e-01 -1.13e-01 7.14e-02 1.58e-02 2.62e-02
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 18 6.41e-01 6.95e-01 0.1890 -0.029000 -7.29e-02 -1.72e-01 8.32e-01 5.92e-01 2.07e-01
Epigenetic regulation of gene expression 103 6.45e-03 1.53e-02 0.1890 0.014300 -7.09e-02 -1.74e-01 8.01e-01 2.13e-01 2.22e-03
Diseases associated with glycosaminoglycan metabolism 26 4.50e-01 5.22e-01 0.1890 0.093800 6.73e-02 -1.49e-01 4.08e-01 5.53e-01 1.88e-01
Peptide hormone metabolism 49 1.42e-01 2.05e-01 0.1870 0.151000 8.05e-02 7.70e-02 6.79e-02 3.30e-01 3.51e-01
Death Receptor Signalling 131 1.94e-02 3.99e-02 0.1870 0.142000 1.03e-01 -6.27e-02 4.89e-03 4.10e-02 2.15e-01
Fcgamma receptor (FCGR) dependent phagocytosis 147 7.55e-06 4.24e-05 0.1860 0.160000 2.68e-02 -9.12e-02 7.91e-04 5.74e-01 5.62e-02
TP53 Regulates Transcription of DNA Repair Genes 61 1.69e-01 2.37e-01 0.1860 -0.050500 -8.22e-02 -1.59e-01 4.95e-01 2.67e-01 3.16e-02
EGR2 and SOX10-mediated initiation of Schwann cell myelination 22 1.00e-01 1.56e-01 0.1860 0.014200 1.52e-01 -1.07e-01 9.08e-01 2.18e-01 3.86e-01
Signaling by ERBB2 KD Mutants 20 1.65e-01 2.33e-01 0.1860 0.184000 2.24e-02 -9.37e-03 1.54e-01 8.62e-01 9.42e-01
Regulation of TP53 Degradation 35 2.96e-01 3.70e-01 0.1860 0.000669 -7.13e-02 -1.71e-01 9.95e-01 4.65e-01 7.94e-02
Fc epsilon receptor (FCERI) signaling 190 4.84e-11 6.58e-10 0.1860 0.144000 -3.24e-02 -1.12e-01 6.00e-04 4.42e-01 7.79e-03
CRMPs in Sema3A signaling 14 2.82e-01 3.56e-01 0.1850 -0.017600 1.02e-01 -1.54e-01 9.09e-01 5.09e-01 3.19e-01
TCR signaling 121 2.33e-03 6.45e-03 0.1850 0.076700 -2.82e-03 -1.69e-01 1.45e-01 9.57e-01 1.35e-03
Cell surface interactions at the vascular wall 173 1.66e-09 1.79e-08 0.1850 0.133000 -3.84e-02 -1.23e-01 2.64e-03 3.84e-01 5.30e-03
Phase 2 - plateau phase 17 6.05e-01 6.61e-01 0.1850 -0.092100 -2.83e-02 1.57e-01 5.11e-01 8.40e-01 2.61e-01
RNA Polymerase III Abortive And Retractive Initiation 41 4.67e-01 5.38e-01 0.1840 -0.094200 -1.25e-01 -9.69e-02 2.97e-01 1.65e-01 2.83e-01
RNA Polymerase III Transcription 41 4.67e-01 5.38e-01 0.1840 -0.094200 -1.25e-01 -9.69e-02 2.97e-01 1.65e-01 2.83e-01
SUMOylation of transcription factors 16 8.33e-01 8.61e-01 0.1830 0.127000 1.29e-01 2.25e-02 3.78e-01 3.71e-01 8.76e-01
VEGFR2 mediated vascular permeability 26 3.95e-01 4.67e-01 0.1820 0.077100 1.11e-01 -1.23e-01 4.96e-01 3.29e-01 2.79e-01
Interleukin-20 family signaling 17 7.56e-01 7.98e-01 0.1800 0.108000 1.44e-01 -1.19e-02 4.40e-01 3.05e-01 9.32e-01
Regulation of PTEN mRNA translation 13 6.12e-01 6.68e-01 0.1800 -0.061200 4.68e-02 1.62e-01 7.02e-01 7.70e-01 3.11e-01
Gene expression (Transcription) 1324 9.06e-15 1.84e-13 0.1790 -0.102000 -1.23e-01 -8.02e-02 5.50e-10 4.77e-14 9.77e-07
Activation of RAC1 11 8.04e-01 8.38e-01 0.1790 0.156000 8.63e-02 1.03e-02 3.70e-01 6.20e-01 9.53e-01
APC/C:Cdc20 mediated degradation of Cyclin B 24 1.19e-01 1.78e-01 0.1780 0.079100 -9.03e-02 -1.31e-01 5.02e-01 4.44e-01 2.66e-01
CD28 co-stimulation 33 1.61e-01 2.29e-01 0.1780 -0.053100 8.89e-03 -1.69e-01 5.97e-01 9.30e-01 9.26e-02
Generic Transcription Pathway 1075 3.64e-12 5.63e-11 0.1770 -0.102000 -1.13e-01 -9.06e-02 1.67e-08 3.50e-10 5.25e-07
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 4.06e-01 4.78e-01 0.1770 0.005010 -5.44e-02 -1.68e-01 9.61e-01 6.00e-01 1.05e-01
Meiotic recombination 38 4.28e-01 5.01e-01 0.1770 0.122000 9.22e-02 -8.84e-02 1.92e-01 3.25e-01 3.46e-01
Glucose metabolism 83 6.71e-02 1.12e-01 0.1770 0.094400 7.03e-02 -1.32e-01 1.37e-01 2.68e-01 3.78e-02
Gene Silencing by RNA 87 2.02e-02 4.12e-02 0.1770 -0.002430 -9.74e-02 -1.47e-01 9.69e-01 1.16e-01 1.75e-02
FCGR3A-mediated phagocytosis 121 2.06e-06 1.35e-05 0.1760 0.152000 -1.41e-02 -8.74e-02 3.88e-03 7.89e-01 9.67e-02
Leishmania phagocytosis 121 2.06e-06 1.35e-05 0.1760 0.152000 -1.41e-02 -8.74e-02 3.88e-03 7.89e-01 9.67e-02
Parasite infection 121 2.06e-06 1.35e-05 0.1760 0.152000 -1.41e-02 -8.74e-02 3.88e-03 7.89e-01 9.67e-02
Sema3A PAK dependent Axon repulsion 16 6.91e-01 7.41e-01 0.1760 0.078500 6.85e-02 -1.41e-01 5.87e-01 6.35e-01 3.27e-01
Resolution of Sister Chromatid Cohesion 104 1.86e-02 3.85e-02 0.1750 -0.008930 3.36e-03 1.75e-01 8.75e-01 9.53e-01 2.08e-03
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 91 3.62e-02 6.75e-02 0.1750 -0.040400 -6.98e-03 1.70e-01 5.06e-01 9.08e-01 5.15e-03
Amplification of signal from the kinetochores 91 3.62e-02 6.75e-02 0.1750 -0.040400 -6.98e-03 1.70e-01 5.06e-01 9.08e-01 5.15e-03
G0 and Early G1 27 3.81e-02 7.09e-02 0.1740 0.017100 -1.69e-01 -3.88e-02 8.78e-01 1.28e-01 7.27e-01
mRNA 3'-end processing 56 1.04e-01 1.60e-01 0.1740 -0.040000 -1.38e-01 -9.87e-02 6.04e-01 7.36e-02 2.01e-01
Class I peroxisomal membrane protein import 20 4.38e-01 5.11e-01 0.1740 -0.125000 -4.47e-02 -1.12e-01 3.34e-01 7.29e-01 3.86e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 23 4.90e-01 5.57e-01 0.1730 0.081400 5.43e-03 -1.52e-01 4.99e-01 9.64e-01 2.06e-01
Zinc transporters 14 8.20e-01 8.51e-01 0.1720 0.133000 9.35e-02 -5.78e-02 3.90e-01 5.45e-01 7.08e-01
DCC mediated attractive signaling 13 7.76e-01 8.14e-01 0.1720 -0.001430 -4.10e-02 -1.67e-01 9.93e-01 7.98e-01 2.97e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation 34 3.73e-01 4.43e-01 0.1710 0.046400 -2.26e-04 -1.65e-01 6.40e-01 9.98e-01 9.57e-02
Metal ion SLC transporters 21 7.71e-01 8.10e-01 0.1710 0.133000 1.07e-01 -1.46e-03 2.90e-01 3.95e-01 9.91e-01
GABA synthesis, release, reuptake and degradation 13 8.04e-01 8.38e-01 0.1710 -0.031300 -8.30e-02 -1.46e-01 8.45e-01 6.04e-01 3.61e-01
Nuclear Envelope Breakdown 53 2.52e-01 3.25e-01 0.1710 -0.095100 -1.36e-01 4.02e-02 2.31e-01 8.62e-02 6.13e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 20 5.01e-01 5.69e-01 0.1710 -0.019400 -1.24e-01 -1.16e-01 8.80e-01 3.35e-01 3.71e-01
TP53 Regulates Transcription of Cell Death Genes 42 1.74e-01 2.43e-01 0.1700 0.158000 6.23e-02 3.66e-03 7.55e-02 4.85e-01 9.67e-01
SUMOylation of transcription cofactors 44 2.71e-01 3.45e-01 0.1700 0.063800 2.33e-02 -1.56e-01 4.64e-01 7.89e-01 7.32e-02
Regulation of TP53 Activity 151 5.46e-02 9.54e-02 0.1700 -0.101000 -1.07e-01 -8.52e-02 3.17e-02 2.32e-02 7.06e-02
Miscellaneous transport and binding events 20 4.39e-01 5.11e-01 0.1700 0.146000 3.37e-02 -8.08e-02 2.60e-01 7.94e-01 5.32e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 17 7.23e-01 7.68e-01 0.1680 -0.083200 -1.45e-01 -1.11e-02 5.53e-01 3.00e-01 9.37e-01
FOXO-mediated transcription of cell cycle genes 15 7.29e-01 7.73e-01 0.1680 0.014000 -5.70e-03 -1.67e-01 9.25e-01 9.69e-01 2.63e-01
Association of TriC/CCT with target proteins during biosynthesis 37 3.61e-01 4.32e-01 0.1670 0.044700 1.93e-02 -1.60e-01 6.38e-01 8.39e-01 9.21e-02
Orc1 removal from chromatin 69 7.05e-02 1.16e-01 0.1670 0.138000 4.98e-02 -7.94e-02 4.75e-02 4.74e-01 2.54e-01
Regulation of TNFR1 signaling 32 6.34e-01 6.88e-01 0.1670 -0.109000 -9.54e-02 -8.20e-02 2.84e-01 3.51e-01 4.22e-01
Deadenylation-dependent mRNA decay 53 1.82e-02 3.78e-02 0.1660 -0.013200 -1.56e-01 -5.72e-02 8.68e-01 5.00e-02 4.72e-01
RNA Polymerase II Pre-transcription Events 78 7.32e-02 1.20e-01 0.1660 0.128000 5.39e-02 -9.05e-02 5.02e-02 4.11e-01 1.67e-01
APC-Cdc20 mediated degradation of Nek2A 26 1.81e-01 2.50e-01 0.1650 0.019800 -1.27e-01 -1.04e-01 8.62e-01 2.62e-01 3.60e-01
Signaling by Activin 10 8.85e-01 9.05e-01 0.1640 -0.134000 -8.64e-02 -3.82e-02 4.62e-01 6.36e-01 8.34e-01
Regulation of pyruvate dehydrogenase (PDH) complex 15 6.44e-01 6.98e-01 0.1640 0.108000 4.33e-02 1.16e-01 4.70e-01 7.72e-01 4.36e-01
MET activates PTK2 signaling 15 6.23e-01 6.77e-01 0.1640 0.144000 5.54e-02 5.50e-02 3.34e-01 7.10e-01 7.12e-01
Cilium Assembly 181 3.87e-02 7.16e-02 0.1630 -0.103000 -1.25e-01 -2.38e-02 1.69e-02 3.80e-03 5.80e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 14 2.76e-01 3.50e-01 0.1630 -0.026800 1.13e-01 -1.15e-01 8.62e-01 4.64e-01 4.57e-01
Amino acid transport across the plasma membrane 23 5.62e-01 6.25e-01 0.1630 0.146000 7.05e-02 1.71e-02 2.25e-01 5.58e-01 8.87e-01
RUNX2 regulates osteoblast differentiation 18 5.26e-02 9.21e-02 0.1630 -0.072800 1.45e-01 -2.96e-03 5.93e-01 2.86e-01 9.83e-01
Peptide ligand-binding receptors 91 1.12e-01 1.71e-01 0.1620 0.092500 1.26e-01 -4.06e-02 1.27e-01 3.75e-02 5.04e-01
HIV Transcription Initiation 45 6.70e-02 1.12e-01 0.1610 0.137000 7.26e-03 -8.42e-02 1.11e-01 9.33e-01 3.28e-01
RNA Polymerase II HIV Promoter Escape 45 6.70e-02 1.12e-01 0.1610 0.137000 7.26e-03 -8.42e-02 1.11e-01 9.33e-01 3.28e-01
RNA Polymerase II Promoter Escape 45 6.70e-02 1.12e-01 0.1610 0.137000 7.26e-03 -8.42e-02 1.11e-01 9.33e-01 3.28e-01
RNA Polymerase II Transcription Initiation 45 6.70e-02 1.12e-01 0.1610 0.137000 7.26e-03 -8.42e-02 1.11e-01 9.33e-01 3.28e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance 45 6.70e-02 1.12e-01 0.1610 0.137000 7.26e-03 -8.42e-02 1.11e-01 9.33e-01 3.28e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 45 6.70e-02 1.12e-01 0.1610 0.137000 7.26e-03 -8.42e-02 1.11e-01 9.33e-01 3.28e-01
Ca2+ pathway 57 4.63e-01 5.35e-01 0.1610 0.112000 1.15e-01 -8.25e-03 1.43e-01 1.33e-01 9.14e-01
Signaling by FGFR4 in disease 11 4.39e-01 5.11e-01 0.1600 0.069300 -5.67e-02 1.33e-01 6.91e-01 7.45e-01 4.45e-01
Activation of NMDA receptors and postsynaptic events 58 1.39e-01 2.02e-01 0.1600 0.099500 2.02e-02 -1.24e-01 1.90e-01 7.90e-01 1.03e-01
Cellular hexose transport 15 8.71e-01 8.92e-01 0.1600 -0.102000 -9.39e-02 -7.88e-02 4.93e-01 5.29e-01 5.97e-01
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 17 8.46e-01 8.70e-01 0.1590 -0.086200 -1.22e-01 -5.37e-02 5.38e-01 3.83e-01 7.02e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 17 5.07e-01 5.75e-01 0.1590 -0.027600 9.30e-02 1.26e-01 8.44e-01 5.07e-01 3.69e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 17 5.07e-01 5.75e-01 0.1590 -0.027600 9.30e-02 1.26e-01 8.44e-01 5.07e-01 3.69e-01
Molecules associated with elastic fibres 22 7.08e-01 7.55e-01 0.1590 0.115000 7.31e-02 -8.13e-02 3.51e-01 5.53e-01 5.09e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 6.53e-01 7.06e-01 0.1590 0.083200 5.59e-02 -1.23e-01 4.90e-01 6.43e-01 3.08e-01
RNA Polymerase II Transcription 1194 7.55e-11 9.88e-10 0.1580 -0.085800 -1.05e-01 -8.22e-02 6.02e-07 1.15e-09 1.77e-06
Polo-like kinase mediated events 15 7.75e-01 8.14e-01 0.1580 0.104000 6.33e-02 1.01e-01 4.85e-01 6.71e-01 4.99e-01
Post NMDA receptor activation events 48 2.91e-01 3.64e-01 0.1580 0.093900 3.71e-02 -1.22e-01 2.60e-01 6.57e-01 1.45e-01
Methylation 12 8.20e-01 8.51e-01 0.1580 -0.024100 -9.74e-02 -1.21e-01 8.85e-01 5.59e-01 4.66e-01
Inactivation of APC/C via direct inhibition of the APC/C complex 21 3.53e-01 4.23e-01 0.1570 -0.030500 -1.53e-01 -2.34e-02 8.09e-01 2.26e-01 8.53e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 21 3.53e-01 4.23e-01 0.1570 -0.030500 -1.53e-01 -2.34e-02 8.09e-01 2.26e-01 8.53e-01
Synthesis of PIPs at the Golgi membrane 16 5.71e-01 6.33e-01 0.1570 0.049200 1.49e-01 -1.71e-03 7.33e-01 3.03e-01 9.91e-01
G alpha (i) signalling events 241 5.84e-03 1.41e-02 0.1570 0.101000 1.09e-01 -4.91e-02 6.74e-03 3.66e-03 1.89e-01
NRAGE signals death through JNK 52 2.87e-01 3.61e-01 0.1550 0.073500 8.35e-02 -1.08e-01 3.59e-01 2.98e-01 1.77e-01
Regulation of TP53 Activity through Phosphorylation 88 1.72e-01 2.39e-01 0.1550 -0.095900 -9.62e-02 7.46e-02 1.20e-01 1.19e-01 2.26e-01
Phase I - Functionalization of compounds 61 3.16e-01 3.88e-01 0.1530 0.098100 7.40e-02 -9.10e-02 1.85e-01 3.18e-01 2.19e-01
Signaling by FGFR 69 2.30e-01 3.03e-01 0.1530 0.090600 6.23e-02 -1.06e-01 1.93e-01 3.71e-01 1.27e-01
Metabolism of folate and pterines 16 7.05e-01 7.53e-01 0.1530 0.138000 5.45e-02 -3.60e-02 3.40e-01 7.06e-01 8.03e-01
Metabolic disorders of biological oxidation enzymes 23 7.68e-01 8.08e-01 0.1520 0.097200 1.09e-01 -4.23e-02 4.19e-01 3.66e-01 7.26e-01
Interaction between L1 and Ankyrins 21 6.72e-01 7.24e-01 0.1520 0.006460 9.06e-03 1.51e-01 9.59e-01 9.43e-01 2.30e-01
EML4 and NUDC in mitotic spindle formation 95 8.27e-02 1.33e-01 0.1520 -0.021500 2.67e-03 1.50e-01 7.17e-01 9.64e-01 1.15e-02
SLC-mediated transmembrane transport 179 5.75e-02 9.98e-02 0.1510 0.104000 1.07e-01 -2.25e-02 1.66e-02 1.33e-02 6.04e-01
Ion homeostasis 40 1.36e-01 1.98e-01 0.1490 0.015800 9.09e-02 -1.17e-01 8.62e-01 3.20e-01 1.99e-01
Mitotic Prophase 98 1.30e-01 1.91e-01 0.1490 0.117000 6.75e-02 -6.35e-02 4.62e-02 2.48e-01 2.78e-01
Ion transport by P-type ATPases 42 2.34e-01 3.06e-01 0.1490 0.055700 1.34e-01 -3.30e-02 5.32e-01 1.33e-01 7.11e-01
KSRP (KHSRP) binds and destabilizes mRNA 17 6.34e-01 6.88e-01 0.1480 -0.025800 -1.25e-01 -7.49e-02 8.54e-01 3.71e-01 5.93e-01
Cytochrome P450 - arranged by substrate type 33 7.55e-01 7.98e-01 0.1480 0.101000 1.07e-01 1.70e-02 3.16e-01 2.86e-01 8.66e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS 10 8.44e-01 8.69e-01 0.1480 0.009340 -7.15e-02 -1.29e-01 9.59e-01 6.95e-01 4.79e-01
Defective EXT2 causes exostoses 2 10 8.44e-01 8.69e-01 0.1480 0.009340 -7.15e-02 -1.29e-01 9.59e-01 6.95e-01 4.79e-01
Signaling by GPCR 530 1.14e-06 8.33e-06 0.1480 0.079500 1.24e-01 -1.60e-02 1.74e-03 1.10e-06 5.28e-01
Xenobiotics 11 6.82e-01 7.33e-01 0.1480 -0.000808 -1.24e-01 -8.05e-02 9.96e-01 4.77e-01 6.44e-01
Ovarian tumor domain proteases 37 5.87e-01 6.46e-01 0.1470 0.068800 1.21e-01 4.86e-02 4.69e-01 2.03e-01 6.09e-01
Cytosolic sensors of pathogen-associated DNA 62 2.48e-01 3.21e-01 0.1470 0.033600 5.68e-03 -1.43e-01 6.47e-01 9.38e-01 5.14e-02
Branched-chain amino acid catabolism 21 7.09e-01 7.55e-01 0.1470 -0.060600 -5.58e-02 1.22e-01 6.31e-01 6.58e-01 3.35e-01
Lysosphingolipid and LPA receptors 11 8.36e-01 8.63e-01 0.1460 -0.020800 -3.81e-03 -1.45e-01 9.05e-01 9.83e-01 4.05e-01
Cytokine Signaling in Immune system 732 3.82e-06 2.38e-05 0.1460 0.107000 9.71e-02 -2.52e-02 9.28e-07 7.79e-06 2.46e-01
TICAM1-dependent activation of IRF3/IRF7 12 8.20e-01 8.51e-01 0.1460 0.071900 5.09e-03 -1.27e-01 6.66e-01 9.76e-01 4.46e-01
DAP12 signaling 28 3.34e-01 4.06e-01 0.1450 0.041200 1.28e-01 -5.38e-02 7.06e-01 2.41e-01 6.22e-01
Nuclear Envelope (NE) Reassembly 69 2.76e-01 3.50e-01 0.1450 0.114000 6.39e-02 -6.17e-02 1.01e-01 3.58e-01 3.76e-01
Antigen processing: Ubiquitination & Proteasome degradation 287 5.12e-03 1.26e-02 0.1440 0.108000 8.02e-02 -5.21e-02 1.69e-03 1.93e-02 1.29e-01
RNA polymerase II transcribes snRNA genes 72 3.52e-01 4.23e-01 0.1440 0.113000 7.92e-02 3.96e-02 9.59e-02 2.45e-01 5.61e-01
Signaling by FGFR2 in disease 32 1.84e-01 2.53e-01 0.1430 0.039700 -9.35e-02 -1.00e-01 6.97e-01 3.60e-01 3.25e-01
GPCR downstream signalling 488 9.09e-06 4.98e-05 0.1420 0.076100 1.20e-01 -1.36e-02 4.01e-03 6.04e-06 6.06e-01
DNA Repair 289 2.10e-02 4.28e-02 0.1420 -0.084400 -9.86e-02 -5.86e-02 1.36e-02 3.93e-03 8.67e-02
Mitotic Anaphase 223 2.75e-02 5.34e-02 0.1420 0.114000 8.20e-02 2.18e-02 3.38e-03 3.48e-02 5.75e-01
SUMO E3 ligases SUMOylate target proteins 159 6.57e-02 1.11e-01 0.1410 -0.044200 -8.00e-02 -1.08e-01 3.36e-01 8.17e-02 1.90e-02
Phase II - Conjugation of compounds 67 4.77e-01 5.46e-01 0.1410 0.108000 8.52e-02 3.10e-02 1.27e-01 2.28e-01 6.61e-01
Mitotic Spindle Checkpoint 108 7.72e-02 1.25e-01 0.1410 -0.034100 -2.49e-02 1.34e-01 5.40e-01 6.55e-01 1.60e-02
SUMOylation 165 7.47e-02 1.22e-01 0.1400 -0.052500 -8.70e-02 -9.65e-02 2.45e-01 5.37e-02 3.25e-02
Anti-inflammatory response favouring Leishmania parasite infection 169 1.40e-03 4.16e-03 0.1400 0.014200 -8.20e-02 -1.12e-01 7.51e-01 6.59e-02 1.20e-02
Leishmania parasite growth and survival 169 1.40e-03 4.16e-03 0.1400 0.014200 -8.20e-02 -1.12e-01 7.51e-01 6.59e-02 1.20e-02
Glycolysis 66 2.95e-01 3.69e-01 0.1390 0.089800 4.55e-02 -9.64e-02 2.07e-01 5.23e-01 1.76e-01
Transcription of the HIV genome 67 1.23e-01 1.83e-01 0.1390 0.080400 -5.32e-03 -1.13e-01 2.55e-01 9.40e-01 1.08e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 4.87e-01 5.54e-01 0.1390 0.062700 4.98e-02 -1.14e-01 4.77e-01 5.72e-01 1.98e-01
Non-integrin membrane-ECM interactions 37 4.13e-01 4.84e-01 0.1380 0.116000 3.55e-02 -6.52e-02 2.22e-01 7.09e-01 4.92e-01
PI-3K cascade:FGFR4 10 5.13e-01 5.78e-01 0.1380 0.098000 -4.13e-02 8.77e-02 5.92e-01 8.21e-01 6.31e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 14 8.12e-01 8.46e-01 0.1380 0.013400 8.69e-05 1.37e-01 9.31e-01 1.00e+00 3.75e-01
Mitotic Metaphase and Anaphase 224 3.43e-02 6.43e-02 0.1360 0.109000 7.74e-02 2.47e-02 4.84e-03 4.60e-02 5.24e-01
Synthesis of DNA 118 5.23e-02 9.16e-02 0.1360 -0.034600 -1.10e-01 -7.20e-02 5.17e-01 3.95e-02 1.77e-01
DNA Double-Strand Break Repair 135 2.07e-01 2.78e-01 0.1350 -0.105000 -8.40e-02 1.12e-02 3.53e-02 9.18e-02 8.23e-01
CTLA4 inhibitory signaling 21 4.70e-01 5.40e-01 0.1340 -0.017800 5.16e-02 -1.23e-01 8.88e-01 6.82e-01 3.30e-01
Processing of Intronless Pre-mRNAs 19 9.07e-01 9.26e-01 0.1340 -0.089200 -9.53e-02 -3.07e-02 5.01e-01 4.72e-01 8.17e-01
Signaling by FGFR in disease 51 3.36e-01 4.08e-01 0.1340 0.120000 5.36e-02 2.43e-02 1.37e-01 5.08e-01 7.64e-01
Glucagon-type ligand receptors 20 6.72e-01 7.25e-01 0.1340 0.038300 7.63e-02 -1.03e-01 7.67e-01 5.55e-01 4.26e-01
Prolactin receptor signaling 11 5.85e-01 6.45e-01 0.1320 0.080400 -3.32e-02 9.87e-02 6.44e-01 8.49e-01 5.71e-01
RHO GTPases Activate Formins 117 1.35e-01 1.98e-01 0.1310 0.017600 6.43e-02 1.13e-01 7.42e-01 2.30e-01 3.49e-02
HCMV Early Events 74 1.51e-01 2.17e-01 0.1300 0.014400 -6.62e-02 -1.11e-01 8.30e-01 3.25e-01 1.00e-01
Nonhomologous End-Joining (NHEJ) 42 7.09e-01 7.55e-01 0.1290 0.085600 9.16e-02 -2.91e-02 3.37e-01 3.05e-01 7.44e-01
Transcriptional activation of mitochondrial biogenesis 51 5.52e-01 6.18e-01 0.1280 0.097800 6.06e-02 -5.71e-02 2.27e-01 4.54e-01 4.80e-01
HIV Life Cycle 144 1.38e-02 3.01e-02 0.1280 0.042900 -3.83e-02 -1.15e-01 3.74e-01 4.28e-01 1.76e-02
Homology Directed Repair 110 3.71e-01 4.42e-01 0.1280 -0.092800 -8.68e-02 1.16e-02 9.27e-02 1.16e-01 8.34e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 73 2.61e-01 3.34e-01 0.1270 0.091200 3.29e-02 -8.27e-02 1.78e-01 6.27e-01 2.22e-01
Adaptive Immune System 755 5.39e-07 4.26e-06 0.1260 0.073300 4.64e-02 -9.14e-02 6.07e-04 3.02e-02 1.93e-05
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 24 6.64e-01 7.17e-01 0.1260 0.068300 -3.46e-03 -1.06e-01 5.63e-01 9.77e-01 3.71e-01
Late Phase of HIV Life Cycle 131 2.80e-02 5.44e-02 0.1250 0.059800 -1.72e-02 -1.09e-01 2.38e-01 7.35e-01 3.15e-02
S Phase 160 2.49e-02 4.96e-02 0.1250 -0.035400 -1.07e-01 -5.37e-02 4.40e-01 1.96e-02 2.42e-01
Switching of origins to a post-replicative state 89 7.09e-02 1.17e-01 0.1250 0.102000 1.44e-02 -7.00e-02 9.57e-02 8.14e-01 2.54e-01
The phototransduction cascade 25 8.64e-01 8.86e-01 0.1250 -0.096300 -7.47e-02 -2.62e-02 4.04e-01 5.18e-01 8.21e-01
Separation of Sister Chromatids 167 9.64e-02 1.52e-01 0.1250 0.094500 6.25e-02 5.18e-02 3.52e-02 1.64e-01 2.48e-01
Synthesis of glycosylphosphatidylinositol (GPI) 17 9.16e-01 9.32e-01 0.1240 -0.080100 -9.44e-02 1.22e-02 5.67e-01 5.00e-01 9.30e-01
STING mediated induction of host immune responses 15 8.52e-01 8.75e-01 0.1240 0.086800 2.97e-02 -8.34e-02 5.60e-01 8.42e-01 5.76e-01
Mitotic Prometaphase 185 5.10e-02 9.00e-02 0.1190 -0.051700 -3.32e-02 1.02e-01 2.25e-01 4.36e-01 1.63e-02
Basigin interactions 23 7.87e-01 8.24e-01 0.1190 0.067800 2.19e-02 -9.55e-02 5.74e-01 8.56e-01 4.28e-01
Nicotinate metabolism 25 3.94e-01 4.66e-01 0.1190 -0.013800 1.04e-01 5.67e-02 9.05e-01 3.69e-01 6.24e-01
Biological oxidations 133 2.18e-01 2.89e-01 0.1190 0.092900 6.03e-02 -4.36e-02 6.43e-02 2.29e-01 3.86e-01
Cell-cell junction organization 36 5.61e-01 6.25e-01 0.1190 0.043200 -2.26e-02 -1.08e-01 6.54e-01 8.14e-01 2.61e-01
Class B/2 (Secretin family receptors) 56 3.01e-01 3.74e-01 0.1180 0.019100 5.38e-02 -1.03e-01 8.05e-01 4.87e-01 1.80e-01
Processing and activation of SUMO 10 7.95e-01 8.31e-01 0.1180 0.054500 -1.85e-02 1.03e-01 7.65e-01 9.19e-01 5.73e-01
Glutathione synthesis and recycling 10 9.30e-01 9.44e-01 0.1160 0.010500 -4.04e-02 -1.08e-01 9.54e-01 8.25e-01 5.54e-01
Nucleotide-like (purinergic) receptors 12 9.59e-01 9.66e-01 0.1160 0.091800 7.03e-02 4.60e-04 5.82e-01 6.73e-01 9.98e-01
DNA Replication Pre-Initiation 82 1.16e-01 1.74e-01 0.1150 0.048000 -3.83e-02 -9.69e-02 4.52e-01 5.49e-01 1.29e-01
Constitutive Signaling by Aberrant PI3K in Cancer 54 5.34e-01 5.99e-01 0.1130 0.058300 1.87e-02 -9.49e-02 4.59e-01 8.12e-01 2.28e-01
DNA Replication 125 6.85e-02 1.14e-01 0.1110 -0.021700 -9.64e-02 -5.13e-02 6.75e-01 6.27e-02 3.22e-01
NCAM signaling for neurite out-growth 43 8.31e-01 8.59e-01 0.1110 -0.080400 -7.40e-02 -2.07e-02 3.62e-01 4.01e-01 8.15e-01
Class A/1 (Rhodopsin-like receptors) 160 5.31e-02 9.29e-02 0.1110 0.045400 8.27e-02 -5.79e-02 3.22e-01 7.12e-02 2.06e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 13 9.14e-01 9.31e-01 0.1090 0.029500 1.69e-02 1.04e-01 8.54e-01 9.16e-01 5.17e-01
M Phase 360 4.34e-02 7.88e-02 0.1070 0.086600 6.34e-02 -1.22e-03 4.80e-03 3.90e-02 9.68e-01
PERK regulates gene expression 30 1.25e-01 1.85e-01 0.1070 0.091100 -5.62e-02 2.57e-03 3.88e-01 5.94e-01 9.81e-01
Post-translational modification: synthesis of GPI-anchored proteins 57 6.65e-01 7.18e-01 0.1070 0.064100 7.55e-02 -4.07e-02 4.03e-01 3.24e-01 5.95e-01
O-linked glycosylation 83 6.38e-02 1.09e-01 0.1060 -0.054700 1.59e-02 -8.99e-02 3.89e-01 8.03e-01 1.57e-01
G1/S Transition 130 2.36e-02 4.74e-02 0.1060 0.002030 -8.84e-02 -5.85e-02 9.68e-01 8.16e-02 2.49e-01
G2/M DNA damage checkpoint 67 5.10e-01 5.76e-01 0.1060 -0.040700 -3.45e-02 9.16e-02 5.65e-01 6.25e-01 1.95e-01
CLEC7A (Dectin-1) induces NFAT activation 11 9.28e-01 9.43e-01 0.1060 -0.034400 -1.34e-02 -9.92e-02 8.44e-01 9.38e-01 5.69e-01
Diseases of metabolism 187 4.56e-02 8.24e-02 0.1050 0.029100 4.81e-02 -8.91e-02 4.92e-01 2.57e-01 3.57e-02
Recruitment of NuMA to mitotic centrosomes 80 5.74e-01 6.34e-01 0.1040 -0.084500 -5.65e-02 -2.44e-02 1.92e-01 3.83e-01 7.06e-01
SLC transporter disorders 75 3.99e-01 4.71e-01 0.1040 -0.007780 -6.54e-02 -8.05e-02 9.07e-01 3.27e-01 2.28e-01
Mitotic G2-G2/M phases 181 2.49e-01 3.22e-01 0.1020 0.084800 5.69e-02 -4.75e-03 4.92e-02 1.87e-01 9.12e-01
Transcriptional Regulation by TP53 350 3.92e-03 1.01e-02 0.1020 0.039400 -1.02e-02 -9.35e-02 2.05e-01 7.43e-01 2.65e-03
Signaling by Retinoic Acid 31 7.97e-01 8.31e-01 0.1020 0.019100 9.16e-03 -9.97e-02 8.54e-01 9.30e-01 3.37e-01
Anchoring of the basal body to the plasma membrane 97 5.74e-01 6.34e-01 0.1020 -0.075700 -6.24e-02 2.74e-02 1.98e-01 2.88e-01 6.41e-01
PKMTs methylate histone lysines 44 7.88e-01 8.25e-01 0.1020 -0.072600 -5.18e-02 -4.85e-02 4.05e-01 5.52e-01 5.78e-01
Centrosome maturation 81 6.14e-01 6.68e-01 0.1000 -0.080400 -5.49e-02 -2.36e-02 2.11e-01 3.93e-01 7.14e-01
Recruitment of mitotic centrosome proteins and complexes 81 6.14e-01 6.68e-01 0.1000 -0.080400 -5.49e-02 -2.36e-02 2.11e-01 3.93e-01 7.14e-01
CASP8 activity is inhibited 11 9.45e-01 9.54e-01 0.0999 -0.015200 -1.73e-02 9.72e-02 9.30e-01 9.21e-01 5.77e-01
Dimerization of procaspase-8 11 9.45e-01 9.54e-01 0.0999 -0.015200 -1.73e-02 9.72e-02 9.30e-01 9.21e-01 5.77e-01
Regulation by c-FLIP 11 9.45e-01 9.54e-01 0.0999 -0.015200 -1.73e-02 9.72e-02 9.30e-01 9.21e-01 5.77e-01
IGF1R signaling cascade 36 7.22e-01 7.68e-01 0.0994 0.091500 3.89e-02 -1.07e-03 3.42e-01 6.87e-01 9.91e-01
TP53 Regulates Transcription of Caspase Activators and Caspases 11 7.63e-01 8.04e-01 0.0991 0.007070 -8.49e-02 5.07e-02 9.68e-01 6.26e-01 7.71e-01
Organelle biogenesis and maintenance 269 3.21e-02 6.09e-02 0.0991 -0.015200 -6.67e-02 -7.16e-02 6.67e-01 5.96e-02 4.32e-02
Mitochondrial Fatty Acid Beta-Oxidation 36 7.66e-01 8.06e-01 0.0986 0.024500 2.15e-02 -9.31e-02 7.99e-01 8.23e-01 3.34e-01
Cardiac conduction 91 1.77e-01 2.45e-01 0.0983 0.021400 9.35e-02 2.13e-02 7.24e-01 1.23e-01 7.25e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 104 5.87e-01 6.46e-01 0.0967 -0.067400 -6.35e-02 2.80e-02 2.35e-01 2.63e-01 6.22e-01
Phosphorylation of the APC/C 20 4.12e-01 4.84e-01 0.0954 0.040800 -8.62e-02 -2.90e-03 7.52e-01 5.05e-01 9.82e-01
Cyclin D associated events in G1 47 8.67e-01 8.89e-01 0.0948 0.066100 6.01e-02 3.19e-02 4.33e-01 4.76e-01 7.05e-01
G1 Phase 47 8.67e-01 8.89e-01 0.0948 0.066100 6.01e-02 3.19e-02 4.33e-01 4.76e-01 7.05e-01
Diseases associated with N-glycosylation of proteins 17 7.06e-01 7.53e-01 0.0946 0.048400 -5.15e-02 -6.29e-02 7.30e-01 7.13e-01 6.53e-01
ATF4 activates genes in response to endoplasmic reticulum stress 25 3.62e-01 4.33e-01 0.0943 0.033000 -8.76e-02 -1.10e-02 7.75e-01 4.48e-01 9.24e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 7.97e-01 8.31e-01 0.0942 0.064000 6.84e-02 -9.72e-03 3.80e-01 3.48e-01 8.94e-01
Receptor-type tyrosine-protein phosphatases 12 9.70e-01 9.74e-01 0.0937 0.060100 4.54e-02 5.57e-02 7.19e-01 7.85e-01 7.38e-01
G2/M Transition 179 3.17e-01 3.89e-01 0.0925 0.077500 4.96e-02 -1.02e-02 7.37e-02 2.53e-01 8.14e-01
Formation of Incision Complex in GG-NER 43 1.30e-01 1.92e-01 0.0911 0.036100 -8.33e-02 7.96e-03 6.82e-01 3.45e-01 9.28e-01
Transport of inorganic cations/anions and amino acids/oligopeptides 79 7.25e-01 7.69e-01 0.0884 0.056700 6.29e-02 -2.53e-02 3.83e-01 3.34e-01 6.97e-01
GPCR ligand binding 226 4.37e-02 7.93e-02 0.0852 0.026600 6.50e-02 -4.82e-02 4.91e-01 9.21e-02 2.12e-01
Inactivation, recovery and regulation of the phototransduction cascade 24 9.59e-01 9.66e-01 0.0841 -0.062900 -5.19e-02 -2.04e-02 5.94e-01 6.60e-01 8.63e-01
IRS-related events triggered by IGF1R 35 7.00e-01 7.50e-01 0.0827 0.079600 1.58e-02 -1.60e-02 4.15e-01 8.71e-01 8.70e-01
Eicosanoid ligand-binding receptors 13 9.87e-01 9.89e-01 0.0804 -0.057100 -5.63e-02 -5.97e-03 7.22e-01 7.25e-01 9.70e-01
Signaling by KIT in disease 20 8.20e-01 8.51e-01 0.0803 -0.044500 2.82e-02 6.06e-02 7.31e-01 8.27e-01 6.39e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 20 8.20e-01 8.51e-01 0.0803 -0.044500 2.82e-02 6.06e-02 7.31e-01 8.27e-01 6.39e-01
Transcriptional Regulation by VENTX 38 9.03e-01 9.22e-01 0.0800 -0.058300 -4.09e-02 -3.65e-02 5.34e-01 6.63e-01 6.97e-01
Diseases of glycosylation 108 3.17e-01 3.89e-01 0.0790 -0.016000 1.28e-02 -7.64e-02 7.74e-01 8.19e-01 1.70e-01
Visual phototransduction 58 6.22e-01 6.76e-01 0.0782 0.024300 5.96e-02 -4.43e-02 7.49e-01 4.32e-01 5.59e-01
Signaling by NTRK3 (TRKC) 16 9.33e-01 9.45e-01 0.0781 0.071000 2.17e-02 -2.42e-02 6.23e-01 8.81e-01 8.67e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 37 7.70e-01 8.10e-01 0.0772 0.071500 1.73e-02 -2.36e-02 4.52e-01 8.56e-01 8.04e-01
PI3K Cascade 30 8.28e-01 8.57e-01 0.0741 0.053300 -1.08e-03 -5.14e-02 6.13e-01 9.92e-01 6.26e-01
WNT ligand biogenesis and trafficking 21 9.29e-01 9.43e-01 0.0738 0.066200 2.79e-02 1.70e-02 5.99e-01 8.25e-01 8.93e-01
Interleukin-35 Signalling 12 9.71e-01 9.74e-01 0.0732 -0.020300 -3.08e-02 6.32e-02 9.03e-01 8.53e-01 7.05e-01
Netrin-1 signaling 40 9.00e-01 9.20e-01 0.0731 0.039900 4.62e-02 -4.02e-02 6.62e-01 6.13e-01 6.60e-01
Reproduction 80 7.51e-01 7.94e-01 0.0730 0.043900 2.41e-02 -5.31e-02 4.97e-01 7.09e-01 4.12e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects 20 7.63e-01 8.04e-01 0.0709 0.009560 -6.99e-02 -6.85e-03 9.41e-01 5.88e-01 9.58e-01
Cell Cycle Checkpoints 258 1.43e-01 2.07e-01 0.0699 0.013100 -4.07e-03 6.85e-02 7.18e-01 9.10e-01 5.81e-02
TP53 Regulates Transcription of Cell Cycle Genes 47 2.70e-01 3.45e-01 0.0697 0.045200 -5.29e-02 -4.45e-03 5.92e-01 5.31e-01 9.58e-01
Deposition of new CENPA-containing nucleosomes at the centromere 40 8.43e-01 8.69e-01 0.0688 0.021100 -2.10e-02 -6.20e-02 8.17e-01 8.18e-01 4.98e-01
Nucleosome assembly 40 8.43e-01 8.69e-01 0.0688 0.021100 -2.10e-02 -6.20e-02 8.17e-01 8.18e-01 4.98e-01
Metabolism of vitamins and cofactors 155 5.63e-01 6.25e-01 0.0681 0.035900 5.63e-02 -1.34e-02 4.40e-01 2.27e-01 7.73e-01
Cargo trafficking to the periciliary membrane 47 2.98e-01 3.71e-01 0.0670 0.049600 -4.51e-02 -4.73e-04 5.57e-01 5.93e-01 9.96e-01
Glyoxylate metabolism and glycine degradation 24 8.17e-01 8.50e-01 0.0645 -0.001300 -6.44e-02 -2.88e-03 9.91e-01 5.85e-01 9.81e-01
IRS-mediated signalling 34 7.58e-01 8.00e-01 0.0621 0.062000 2.03e-03 3.20e-03 5.31e-01 9.84e-01 9.74e-01
Processing of DNA double-strand break ends 71 8.52e-01 8.75e-01 0.0619 -0.032500 -4.33e-02 3.01e-02 6.36e-01 5.29e-01 6.61e-01
TNF signaling 42 9.23e-01 9.39e-01 0.0610 0.010200 -7.32e-03 -5.97e-02 9.09e-01 9.35e-01 5.03e-01
Loss of Nlp from mitotic centrosomes 69 7.23e-01 7.68e-01 0.0610 -0.058300 -1.59e-02 8.15e-03 4.02e-01 8.19e-01 9.07e-01
Loss of proteins required for interphase microtubule organization from the centrosome 69 7.23e-01 7.68e-01 0.0610 -0.058300 -1.59e-02 8.15e-03 4.02e-01 8.19e-01 9.07e-01
Synthesis of PA 32 9.64e-01 9.69e-01 0.0608 0.037300 4.12e-02 -2.45e-02 7.15e-01 6.86e-01 8.11e-01
Negative regulators of DDX58/IFIH1 signaling 34 8.72e-01 8.92e-01 0.0603 -0.016600 -5.03e-02 2.88e-02 8.67e-01 6.12e-01 7.71e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1 13 9.11e-01 9.29e-01 0.0599 0.007260 -5.93e-02 -4.26e-03 9.64e-01 7.11e-01 9.79e-01
Mitotic G1 phase and G1/S transition 148 1.18e-01 1.77e-01 0.0592 0.029800 -4.01e-02 -3.17e-02 5.31e-01 4.00e-01 5.06e-01
Glutamate Neurotransmitter Release Cycle 20 9.87e-01 9.89e-01 0.0591 -0.042900 -3.42e-02 -2.19e-02 7.40e-01 7.91e-01 8.65e-01
IL-6-type cytokine receptor ligand interactions 12 9.32e-01 9.45e-01 0.0581 0.037400 -1.56e-02 4.16e-02 8.22e-01 9.25e-01 8.03e-01
Signaling by BMP 21 9.43e-01 9.54e-01 0.0576 -0.009100 -3.36e-02 4.59e-02 9.42e-01 7.90e-01 7.16e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects 36 9.60e-01 9.66e-01 0.0546 -0.033200 -1.89e-02 3.90e-02 7.30e-01 8.44e-01 6.86e-01
Diseases of mitotic cell cycle 36 9.60e-01 9.66e-01 0.0546 -0.033200 -1.89e-02 3.90e-02 7.30e-01 8.44e-01 6.86e-01
G2/M Checkpoints 138 4.74e-01 5.43e-01 0.0526 0.051800 9.18e-03 -2.32e-03 2.94e-01 8.52e-01 9.62e-01
Meiosis 68 9.33e-01 9.45e-01 0.0525 0.036600 2.76e-02 -2.54e-02 6.02e-01 6.94e-01 7.17e-01
TNFR1-induced NFkappaB signaling pathway 25 9.89e-01 9.90e-01 0.0506 -0.036000 -3.42e-02 1.01e-02 7.56e-01 7.67e-01 9.30e-01
AURKA Activation by TPX2 72 7.33e-01 7.77e-01 0.0447 -0.038800 6.93e-03 2.11e-02 5.70e-01 9.19e-01 7.57e-01
Neurotransmitter release cycle 37 9.91e-01 9.91e-01 0.0401 0.020700 2.72e-02 2.10e-02 8.27e-01 7.75e-01 8.25e-01
Kinesins 39 9.51e-01 9.59e-01 0.0376 0.006910 2.79e-02 -2.43e-02 9.40e-01 7.63e-01 7.93e-01
Cell Cycle 623 4.77e-01 5.46e-01 0.0302 -0.011600 -2.68e-02 7.95e-03 6.22e-01 2.54e-01 7.35e-01
Metabolism of water-soluble vitamins and cofactors 109 7.83e-01 8.20e-01 0.0296 -0.029400 3.75e-03 8.88e-04 5.96e-01 9.46e-01 9.87e-01
Regulation of PLK1 Activity at G2/M Transition 87 9.84e-01 9.87e-01 0.0293 -0.020600 -1.78e-02 1.09e-02 7.40e-01 7.74e-01 8.61e-01
Cell Cycle, Mitotic 501 5.93e-01 6.51e-01 0.0176 0.017000 -3.28e-03 2.86e-03 5.14e-01 9.00e-01 9.13e-01


Detailed Gene set reports


IRAK4 deficiency (TLR2/4)

metric value
setSize 10
pMANOVA 7.84e-06
p.adjustMANOVA 4.37e-05
s.dist 1.28
s.t0_v_pod 0.898
s.pod_crp 0.876
s.t0_crp 0.235
p.t0_v_pod 8.77e-07
p.pod_crp 1.61e-06
p.t0_crp 0.198




Gene t0_v_pod pod_crp
CD36 9326 10630.5
TLR2 8919 10240.5
MYD88 7969 10874.5
TLR4 8833 9619.5
TLR1 8891 9510.5
LY96 8726 9505.5
CD14 9013 9117.5
BTK 7051 10605.5
TLR6 8785 8476.5
TIRAP 5630 8500.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BTK 7051 10605.5 9588
CD14 9013 9117.5 -5241
CD36 9326 10630.5 3514
LY96 8726 9505.5 6701
MYD88 7969 10874.5 8291
TIRAP 5630 8500.5 248
TLR1 8891 9510.5 5914
TLR2 8919 10240.5 8626
TLR4 8833 9619.5 3466
TLR6 8785 8476.5 -39



MyD88 deficiency (TLR2/4)

metric value
setSize 10
pMANOVA 7.84e-06
p.adjustMANOVA 4.37e-05
s.dist 1.28
s.t0_v_pod 0.898
s.pod_crp 0.876
s.t0_crp 0.235
p.t0_v_pod 8.77e-07
p.pod_crp 1.61e-06
p.t0_crp 0.198




Gene t0_v_pod pod_crp
CD36 9326 10630.5
TLR2 8919 10240.5
MYD88 7969 10874.5
TLR4 8833 9619.5
TLR1 8891 9510.5
LY96 8726 9505.5
CD14 9013 9117.5
BTK 7051 10605.5
TLR6 8785 8476.5
TIRAP 5630 8500.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BTK 7051 10605.5 9588
CD14 9013 9117.5 -5241
CD36 9326 10630.5 3514
LY96 8726 9505.5 6701
MYD88 7969 10874.5 8291
TIRAP 5630 8500.5 248
TLR1 8891 9510.5 5914
TLR2 8919 10240.5 8626
TLR4 8833 9619.5 3466
TLR6 8785 8476.5 -39



Peptide chain elongation

metric value
setSize 88
pMANOVA 2.05e-65
p.adjustMANOVA 3.49e-63
s.dist 1.15
s.t0_v_pod -0.285
s.pod_crp -0.705
s.t0_crp -0.862
p.t0_v_pod 3.73e-06
p.pod_crp 2.46e-30
p.t0_crp 1.39e-44




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
EEF1A1 -8440 -9481.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EEF1A1 -4906 -9481.5 -8440
EEF2 288 -5359.5 -8900
FAU -398 -3107.5 -8957
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



Eukaryotic Translation Elongation

metric value
setSize 93
pMANOVA 6.85e-69
p.adjustMANOVA 2.33e-66
s.dist 1.14
s.t0_v_pod -0.277
s.pod_crp -0.701
s.t0_crp -0.857
p.t0_v_pod 3.91e-06
p.pod_crp 1.27e-31
p.t0_crp 1.65e-46




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
EEF1B2 -9016 -9444.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
EEF1G -9062 -8852.5
RPS29 -9075 -8819.5
EEF1A1 -8440 -9481.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EEF1A1 -4906 -9481.5 -8440
EEF1A1P5 -1826 -6503.5 -7068
EEF1A2 -5023 -1196.5 1154
EEF1B2 -4162 -9444.5 -9016
EEF1D -821 -5703.5 -8906
EEF1G -1434 -8852.5 -9062
EEF2 288 -5359.5 -8900
FAU -398 -3107.5 -8957
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



Viral mRNA Translation

metric value
setSize 88
pMANOVA 1.89e-61
p.adjustMANOVA 1.98e-59
s.dist 1.11
s.t0_v_pod -0.266
s.pod_crp -0.679
s.t0_crp -0.833
p.t0_v_pod 1.62e-05
p.pod_crp 3.14e-28
p.t0_crp 9.07e-42




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
DNAJC3 8337 9705.5 7588
FAU -398 -3107.5 -8957
GRSF1 5173 108.5 1948
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



Selenocysteine synthesis

metric value
setSize 92
pMANOVA 2.28e-60
p.adjustMANOVA 2.21e-58
s.dist 1.1
s.t0_v_pod -0.303
s.pod_crp -0.685
s.t0_crp -0.806
p.t0_v_pod 5.13e-07
p.pod_crp 5.82e-30
p.t0_crp 7.14e-41




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EEFSEC -9905 -5708.5 -2797
FAU -398 -3107.5 -8957
PSTK -9847 -6597.5 1548
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SARS1 -5763 -4319.5 -6494
SECISBP2 -10159 -7413.5 11029
SEPHS2 7664 8171.5 -6365
SEPSECS -11044 -7942.5 10478
UBA52 1062 -2813.5 -8649



alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

metric value
setSize 12
pMANOVA 1.99e-05
p.adjustMANOVA 1e-04
s.dist 1.1
s.t0_v_pod 0.787
s.pod_crp 0.765
s.t0_crp -0.00551
p.t0_v_pod 2.33e-06
p.pod_crp 4.4e-06
p.t0_crp 0.974




Gene t0_v_pod pod_crp
ACSL1 9177 10671.5
ACAA1 8268 10442.5
ACOX1 8807 9782.5
ELOVL3 8528 9551.5
ACOT8 8006 10041.5
HSD17B4 8729 9124.5
FADS1 7706 10224.5
ELOVL1 7070 9494.5
ABCD1 7223 8387.5
ELOVL5 5990 5188.5
FADS2 1645 7161.5
SCP2 4434 2244.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ABCD1 7223 8387.5 -5678
ACAA1 8268 10442.5 -4182
ACOT8 8006 10041.5 -4063
ACOX1 8807 9782.5 5752
ACSL1 9177 10671.5 2151
ELOVL1 7070 9494.5 -4759
ELOVL3 8528 9551.5 10373
ELOVL5 5990 5188.5 734
FADS1 7706 10224.5 7168
FADS2 1645 7161.5 2833
HSD17B4 8729 9124.5 2794
SCP2 4434 2244.5 5322



alpha-linolenic acid (ALA) metabolism

metric value
setSize 12
pMANOVA 1.99e-05
p.adjustMANOVA 1e-04
s.dist 1.1
s.t0_v_pod 0.787
s.pod_crp 0.765
s.t0_crp -0.00551
p.t0_v_pod 2.33e-06
p.pod_crp 4.4e-06
p.t0_crp 0.974




Gene t0_v_pod pod_crp
ACSL1 9177 10671.5
ACAA1 8268 10442.5
ACOX1 8807 9782.5
ELOVL3 8528 9551.5
ACOT8 8006 10041.5
HSD17B4 8729 9124.5
FADS1 7706 10224.5
ELOVL1 7070 9494.5
ABCD1 7223 8387.5
ELOVL5 5990 5188.5
FADS2 1645 7161.5
SCP2 4434 2244.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ABCD1 7223 8387.5 -5678
ACAA1 8268 10442.5 -4182
ACOT8 8006 10041.5 -4063
ACOX1 8807 9782.5 5752
ACSL1 9177 10671.5 2151
ELOVL1 7070 9494.5 -4759
ELOVL3 8528 9551.5 10373
ELOVL5 5990 5188.5 734
FADS1 7706 10224.5 7168
FADS2 1645 7161.5 2833
HSD17B4 8729 9124.5 2794
SCP2 4434 2244.5 5322



Eukaryotic Translation Termination

metric value
setSize 92
pMANOVA 4.92e-62
p.adjustMANOVA 6.08e-60
s.dist 1.09
s.t0_v_pod -0.268
s.pod_crp -0.669
s.t0_crp -0.822
p.t0_v_pod 9.02e-06
p.pod_crp 1.18e-28
p.t0_crp 2.03e-42




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
APEH 1052 5550.5 -6878
ETF1 7302 7893.5 7446
FAU -398 -3107.5 -8957
GSPT1 6476 -468.5 8999
GSPT2 -9786 -8638.5 -5866
N6AMT1 -10342 -9913.5 -2677
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
TRMT112 581 -2621.5 -9010
UBA52 1062 -2813.5 -8649



Translocation of ZAP-70 to Immunological synapse

metric value
setSize 24
pMANOVA 6.09e-10
p.adjustMANOVA 6.84e-09
s.dist 1.09
s.t0_v_pod -0.744
s.pod_crp -0.737
s.t0_crp -0.285
p.t0_v_pod 2.8e-10
p.pod_crp 4.08e-10
p.t0_crp 0.0156




Gene t0_v_pod pod_crp
TRBC1 -11503 -9646.5
LCK -11140 -9943.5
HLA-DRA -11648 -9127.5
TRAC -10637 -9950.5
ZAP70 -11477 -9167.5
CD247 -11933 -8658.5
CD3E -10696 -9657.5
HLA-DPB1 -11842 -8520.5
TRBV12-3 -9947 -10084.5
HLA-DPA1 -11909 -8382.5
CD3G -11060 -8663.5
CD3D -10748 -8899.5
TRAV8-4 -9067 -10231.5
HLA-DQA1 -11408 -8064.5
HLA-DQB2 -9073 -9739.5
TRAV19 -9695 -9008.5
TRAV29DV5 -9017 -9622.5
TRBV7-9 -9246 -8367.5
HLA-DQA2 -4641 -8079.5
CD4 -5145 -7068.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CD247 -11933 -8658.5 -7294
CD3D -10748 -8899.5 -1723
CD3E -10696 -9657.5 825
CD3G -11060 -8663.5 6100
CD4 -5145 -7068.5 -4207
HLA-DPA1 -11909 -8382.5 4327
HLA-DPB1 -11842 -8520.5 -3185
HLA-DQA1 -11408 -8064.5 4681
HLA-DQA2 -4641 -8079.5 -8418
HLA-DQB1 -5513 -6016.5 -1593
HLA-DQB2 -9073 -9739.5 -7013
HLA-DRA -11648 -9127.5 2478
HLA-DRB1 -7880 -1220.5 8149
HLA-DRB5 -4971 922.5 7335
LCK -11140 -9943.5 -7000
PTPN22 -1098 6754.5 8059
TRAC -10637 -9950.5 328
TRAV19 -9695 -9008.5 -3895
TRAV29DV5 -9017 -9622.5 -1671
TRAV8-4 -9067 -10231.5 -7960
TRBC1 -11503 -9646.5 -2158
TRBV12-3 -9947 -10084.5 -8593
TRBV7-9 -9246 -8367.5 -4513
ZAP70 -11477 -9167.5 -7864



WNT5A-dependent internalization of FZD2, FZD5 and ROR2

metric value
setSize 11
pMANOVA 1.13e-06
p.adjustMANOVA 8.28e-06
s.dist 1.08
s.t0_v_pod 0.678
s.pod_crp 0.659
s.t0_crp -0.528
p.t0_v_pod 9.92e-05
p.pod_crp 0.000154
p.t0_crp 0.00243




Gene t0_v_pod pod_crp
FZD5 9400 10990.5
CLTC 8906 10209.5
AP2M1 8534 9148.5
AP2A1 6537 10946.5
AP2S1 7958 8636.5
CLTA 8272 8299.5
AP2A2 7253 9259.5
CLTB 6108 8327.5
FZD2 6461 5054.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AP2A1 6537 10946.5 315
AP2A2 7253 9259.5 -7222
AP2B1 -2677 2779.5 -3730
AP2M1 8534 9148.5 -8293
AP2S1 7958 8636.5 -5676
CLTA 8272 8299.5 -3488
CLTB 6108 8327.5 -8415
CLTC 8906 10209.5 776
FZD2 6461 5054.5 -5501
FZD5 9400 10990.5 5666
ROR1 -1166 -2350.5 -8935



Formation of a pool of free 40S subunits

metric value
setSize 100
pMANOVA 6.51e-71
p.adjustMANOVA 2.95e-68
s.dist 1.07
s.t0_v_pod -0.212
s.pod_crp -0.666
s.t0_crp -0.808
p.t0_v_pod 0.000253
p.pod_crp 1.06e-30
p.t0_crp 1.81e-44




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
FAU -398 -3107.5 -8957
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

metric value
setSize 94
pMANOVA 4.9e-58
p.adjustMANOVA 3.92e-56
s.dist 1.04
s.t0_v_pod -0.248
s.pod_crp -0.643
s.t0_crp -0.773
p.t0_v_pod 3.28e-05
p.pod_crp 3.79e-27
p.t0_crp 1.53e-38




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF4G1 7959 10173.5 -4453
ETF1 7302 7893.5 7446
FAU -398 -3107.5 -8957
GSPT1 6476 -468.5 8999
GSPT2 -9786 -8638.5 -5866
NCBP1 -5673 -2986.5 10640
NCBP2 -9305 -9742.5 9231
PABPC1 5341 171.5 4499
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649
UPF1 4686 7747.5 -4370



Regulation of TLR by endogenous ligand

metric value
setSize 11
pMANOVA 0.000318
p.adjustMANOVA 0.00115
s.dist 1.01
s.t0_v_pod 0.742
s.pod_crp 0.677
s.t0_crp 0.0613
p.t0_v_pod 2.04e-05
p.pod_crp 9.99e-05
p.t0_crp 0.725




Gene t0_v_pod pod_crp
S100A8 9399 10822.5
CD36 9326 10630.5
S100A9 9401 10256.5
TLR2 8919 10240.5
TLR4 8833 9619.5
TLR1 8891 9510.5
LY96 8726 9505.5
CD14 9013 9117.5
TLR6 8785 8476.5

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t0_v_pod pod_crp t0_crp
CD14 9013 9117.5 -5241
CD36 9326 10630.5 3514
HMGB1 -200 -3813.5 3549
LY96 8726 9505.5 6701
S100A1 -7984 -903.5 4561
S100A8 9399 10822.5 -2187
S100A9 9401 10256.5 -4105
TLR1 8891 9510.5 5914
TLR2 8919 10240.5 8626
TLR4 8833 9619.5 3466
TLR6 8785 8476.5 -39



Uptake and function of anthrax toxins

metric value
setSize 10
pMANOVA 0.000173
p.adjustMANOVA 0.000682
s.dist 0.998
s.t0_v_pod 0.704
s.pod_crp 0.641
s.t0_crp -0.301
p.t0_v_pod 0.000116
p.pod_crp 0.00045
p.t0_crp 0.0993




Gene t0_v_pod pod_crp
FURIN 9011 10589.5
MAP2K6 8861 10607.5
MAP2K1 8813 10257.5
MAP2K3 8643 10123.5
PDCD6IP 6494 8792.5
MAP2K4 6848 7442.5
MAP2K2 6808 7148.5
ANTXR2 7326 6373.5

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t0_v_pod pod_crp t0_crp
ANTXR2 7326 6373.5 -6719
CALM1 -2006 776.5 2755
FURIN 9011 10589.5 -8663
MAP2K1 8813 10257.5 -1581
MAP2K2 6808 7148.5 -8956
MAP2K3 8643 10123.5 -2957
MAP2K4 6848 7442.5 1816
MAP2K6 8861 10607.5 5847
MAP2K7 1634 -156.5 -7691
PDCD6IP 6494 8792.5 9948



Hyaluronan uptake and degradation

metric value
setSize 10
pMANOVA 0.000453
p.adjustMANOVA 0.00159
s.dist 0.996
s.t0_v_pod 0.727
s.pod_crp 0.668
s.t0_crp -0.138
p.t0_v_pod 6.91e-05
p.pod_crp 0.000256
p.t0_crp 0.449




Gene t0_v_pod pod_crp
HYAL2 9005 10825.5
CHP1 9108 10229.5
SLC9A1 7895 10839.5
GUSB 7345 10841.5
CD44 8185 9369.5
HEXB 8607 8736.5
HYAL1 4255 8002.5
HMMR 4012 4804.5
HYAL3 5176 2035.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CD44 8185 9369.5 -1635
CHP1 9108 10229.5 -787
GUSB 7345 10841.5 -76
HEXA 1264 -855.5 -4219
HEXB 8607 8736.5 856
HMMR 4012 4804.5 3507
HYAL1 4255 8002.5 9232
HYAL2 9005 10825.5 -6816
HYAL3 5176 2035.5 2399
SLC9A1 7895 10839.5 -1267



Response of EIF2AK4 (GCN2) to amino acid deficiency

metric value
setSize 100
pMANOVA 1.77e-53
p.adjustMANOVA 1.33e-51
s.dist 0.956
s.t0_v_pod -0.225
s.pod_crp -0.603
s.t0_crp -0.707
p.t0_v_pod 9.85e-05
p.pod_crp 1.85e-25
p.t0_crp 1.84e-34




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ASNS -8016 -7804.5 3753
ATF2 2096 -1804.5 10527
ATF3 -9626 -3162.5 11335
ATF4 6229 1400.5 -4283
CEBPB 7985 10657.5 81
CEBPG 5485 5016.5 5703
DDIT3 4881 4634.5 2712
EIF2AK4 143 835.5 -3554
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
FAU -398 -3107.5 -8957
GCN1 -9952 -6928.5 -3382
IMPACT -3154 -4527.5 10047
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
TRIB3 -5703 616.5 4147
UBA52 1062 -2813.5 -8649



L13a-mediated translational silencing of Ceruloplasmin expression

metric value
setSize 110
pMANOVA 4.55e-67
p.adjustMANOVA 1.24e-64
s.dist 0.954
s.t0_v_pod -0.147
s.pod_crp -0.59
s.t0_crp -0.735
p.t0_v_pod 0.00791
p.pod_crp 9.82e-27
p.t0_crp 1.13e-40




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
FAU -398 -3107.5 -8957
PABPC1 5341 171.5 4499
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



GTP hydrolysis and joining of the 60S ribosomal subunit

metric value
setSize 111
pMANOVA 1.69e-65
p.adjustMANOVA 3.28e-63
s.dist 0.941
s.t0_v_pod -0.151
s.pod_crp -0.586
s.t0_crp -0.721
p.t0_v_pod 0.0061
p.pod_crp 1.17e-26
p.t0_crp 1.85e-39




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
EIF5 2190 2858.5 5909
EIF5B -4511 -4415.5 9845
FAU -398 -3107.5 -8957
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



VLDLR internalisation and degradation

metric value
setSize 11
pMANOVA 2.05e-06
p.adjustMANOVA 1.35e-05
s.dist 0.938
s.t0_v_pod 0.467
s.pod_crp 0.591
s.t0_crp -0.559
p.t0_v_pod 0.00735
p.pod_crp 0.000683
p.t0_crp 0.00133




Gene pod_crp t0_crp
AP2M1 9148.5 -8293
AP2A2 9259.5 -7222
NR1H2 9014.5 -5979
AP2S1 8636.5 -5676
CLTA 8299.5 -3488
NR1H3 3389.5 -7214
AP2B1 2779.5 -3730
VLDLR 5905.5 -1049

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AP2A1 6537 10946.5 315
AP2A2 7253 9259.5 -7222
AP2B1 -2677 2779.5 -3730
AP2M1 8534 9148.5 -8293
AP2S1 7958 8636.5 -5676
CLTA 8272 8299.5 -3488
CLTC 8906 10209.5 776
MYLIP -3880 -4242.5 -6545
NR1H2 7402 9014.5 -5979
NR1H3 -3320 3389.5 -7214
VLDLR -4200 5905.5 -1049



Advanced glycosylation endproduct receptor signaling

metric value
setSize 12
pMANOVA 0.000127
p.adjustMANOVA 0.000512
s.dist 0.918
s.t0_v_pod 0.65
s.pod_crp 0.576
s.t0_crp -0.299
p.t0_v_pod 9.67e-05
p.pod_crp 0.000551
p.t0_crp 0.073




Gene t0_v_pod pod_crp
S100A12 9404 10844.5
LGALS3 8482 9526.5
MAPK1 7410 10809.5
MAPK3 8928 8957.5
CAPZA1 8042 9664.5
CAPZA2 8388 9068.5
APP 8973 7969.5
DDOST 6872 8730.5
PRKCSH 5240 7102.5
AGER 1299 2981.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AGER 1299 2981.5 -1866
APP 8973 7969.5 547
CAPZA1 8042 9664.5 8423
CAPZA2 8388 9068.5 8762
DDOST 6872 8730.5 -8216
HMGB1 -200 -3813.5 3549
LGALS3 8482 9526.5 1346
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
PRKCSH 5240 7102.5 -8456
S100A12 9404 10844.5 -6625
S100B -4861 -3807.5 -8230



RNA Polymerase I Promoter Opening

metric value
setSize 19
pMANOVA 3.8e-08
p.adjustMANOVA 3.52e-07
s.dist 0.908
s.t0_v_pod 0.621
s.pod_crp 0.461
s.t0_crp -0.477
p.t0_v_pod 2.78e-06
p.pod_crp 0.000507
p.t0_crp 0.000322




Gene t0_v_pod t0_crp
MAPK3 8928.0 -9052.0
H2BC12 9025.0 -7638.0
H2AJ 9260.0 -7169.0
H2AZ1 6041.0 -8638.0
H2BC5 8040.0 -4891.0
H3C15 6686.5 -5402.5
H2BC11 7954.0 -4404.0
H2BC15 5393.0 -4378.0
H2AC6 7948.0 -2700.0
H2BC21 9211.0 -2181.0
H2BC17 7392.0 -2437.0
H2BC9 5396.0 -2834.0
H2BC4 7438.0 -575.0

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
H2AC20 4981.0 7901.5 3484.0
H2AC6 7948.0 6588.5 -2700.0
H2AJ 9260.0 11022.5 -7169.0
H2AZ1 6041.0 5160.5 -8638.0
H2AZ2 -1249.0 -3740.5 -7449.0
H2BC11 7954.0 7009.5 -4404.0
H2BC12 9025.0 8965.5 -7638.0
H2BC15 5393.0 5254.5 -4378.0
H2BC17 7392.0 6731.5 -2437.0
H2BC21 9211.0 9169.5 -2181.0
H2BC4 7438.0 8876.5 -575.0
H2BC5 8040.0 7278.5 -4891.0
H2BC9 5396.0 -3277.5 -2834.0
H2BU1 -6302.0 -1745.5 -1518.0
H3-3A 8612.0 9279.5 1082.0
H3C15 6686.5 6812.0 -5402.5
MAPK3 8928.0 8957.5 -9052.0
MBD2 6284.0 8893.5 8443.0
UBTF -9343.0 -9004.5 -8133.0



Erythrocytes take up carbon dioxide and release oxygen

metric value
setSize 11
pMANOVA 0.000323
p.adjustMANOVA 0.00116
s.dist 0.899
s.t0_v_pod 0.72
s.pod_crp 0.513
s.t0_crp -0.162
p.t0_v_pod 3.54e-05
p.pod_crp 0.00323
p.t0_crp 0.353




Gene t0_v_pod pod_crp
CYB5R1 9350 10676.5
CA4 8316 10590.5
CYB5R4 8303 9215.5
CYB5R2 8486 8787.5
CA1 9256 7857.5
AQP1 7245 9309.5
SLC4A1 9044 5508.5
HBA1 8945 4825.5
HBB 8395 5141.5
CA2 3532 444.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AQP1 7245 9309.5 5572
CA1 9256 7857.5 8485
CA2 3532 444.5 -2858
CA4 8316 10590.5 -5429
CYB5R1 9350 10676.5 -7730
CYB5R2 8486 8787.5 2275
CYB5R4 8303 9215.5 6078
CYB5RL -10313 -8238.5 -1037
HBA1 8945 4825.5 -5976
HBB 8395 5141.5 -6980
SLC4A1 9044 5508.5 6157



O2/CO2 exchange in erythrocytes

metric value
setSize 11
pMANOVA 0.000323
p.adjustMANOVA 0.00116
s.dist 0.899
s.t0_v_pod 0.72
s.pod_crp 0.513
s.t0_crp -0.162
p.t0_v_pod 3.54e-05
p.pod_crp 0.00323
p.t0_crp 0.353




Gene t0_v_pod pod_crp
CYB5R1 9350 10676.5
CA4 8316 10590.5
CYB5R4 8303 9215.5
CYB5R2 8486 8787.5
CA1 9256 7857.5
AQP1 7245 9309.5
SLC4A1 9044 5508.5
HBA1 8945 4825.5
HBB 8395 5141.5
CA2 3532 444.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AQP1 7245 9309.5 5572
CA1 9256 7857.5 8485
CA2 3532 444.5 -2858
CA4 8316 10590.5 -5429
CYB5R1 9350 10676.5 -7730
CYB5R2 8486 8787.5 2275
CYB5R4 8303 9215.5 6078
CYB5RL -10313 -8238.5 -1037
HBA1 8945 4825.5 -5976
HBB 8395 5141.5 -6980
SLC4A1 9044 5508.5 6157



Cap-dependent Translation Initiation

metric value
setSize 118
pMANOVA 2.14e-63
p.adjustMANOVA 2.91e-61
s.dist 0.894
s.t0_v_pod -0.135
s.pod_crp -0.553
s.t0_crp -0.69
p.t0_v_pod 0.0113
p.pod_crp 3.07e-25
p.t0_crp 1.75e-38




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2B1 -419 -2021.5 5215
EIF2B2 3268 7114.5 -6756
EIF2B3 -8048 -5218.5 5217
EIF2B4 2711 3517.5 -5330
EIF2B5 -9455 -6527.5 -2707
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4EBP1 6039 4528.5 -3892
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
EIF5 2190 2858.5 5909
EIF5B -4511 -4415.5 9845
FAU -398 -3107.5 -8957
PABPC1 5341 171.5 4499
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



Eukaryotic Translation Initiation

metric value
setSize 118
pMANOVA 2.14e-63
p.adjustMANOVA 2.91e-61
s.dist 0.894
s.t0_v_pod -0.135
s.pod_crp -0.553
s.t0_crp -0.69
p.t0_v_pod 0.0113
p.pod_crp 3.07e-25
p.t0_crp 1.75e-38




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2B1 -419 -2021.5 5215
EIF2B2 3268 7114.5 -6756
EIF2B3 -8048 -5218.5 5217
EIF2B4 2711 3517.5 -5330
EIF2B5 -9455 -6527.5 -2707
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4EBP1 6039 4528.5 -3892
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
EIF5 2190 2858.5 5909
EIF5B -4511 -4415.5 9845
FAU -398 -3107.5 -8957
PABPC1 5341 171.5 4499
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
UBA52 1062 -2813.5 -8649



MET activates RAP1 and RAC1

metric value
setSize 10
pMANOVA 0.0045
p.adjustMANOVA 0.0114
s.dist 0.88
s.t0_v_pod 0.525
s.pod_crp 0.634
s.t0_crp 0.311
p.t0_v_pod 0.00406
p.pod_crp 0.000512
p.t0_crp 0.0887




Gene pod_crp t0_v_pod
GRB2 10574.5 9164
RAC1 10538.5 8578
CRK 10204.5 8795
HGF 10120.5 8712
RAP1A 8328.5 7212
GAB1 8063.5 5652
RAP1B 8354.5 3302
CRKL 4286.5 3947

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CRK 8795 10204.5 6988
CRKL 3947 4286.5 -3487
DOCK7 -2373 -3836.5 4683
GAB1 5652 8063.5 10464
GRB2 9164 10574.5 -1296
HGF 8712 10120.5 10790
RAC1 8578 10538.5 7795
RAP1A 7212 8328.5 9770
RAP1B 3302 8354.5 8566
RAPGEF1 -9705 4657.5 -5090



Selenoamino acid metabolism

metric value
setSize 114
pMANOVA 3.53e-48
p.adjustMANOVA 1.92e-46
s.dist 0.867
s.t0_v_pod -0.232
s.pod_crp -0.56
s.t0_crp -0.62
p.t0_v_pod 1.87e-05
p.pod_crp 4.62e-25
p.t0_crp 2.27e-30




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AHCY 444 -2322.5 -8247
AIMP1 -5656 -8432.5 10102
AIMP2 -896 -826.5 3400
CBS 6274 10600.5 10083
CTH -7816 -3373.5 6939
DARS1 1102 -4182.5 10027
EEF1E1 -2096 -1403.5 -312
EEFSEC -9905 -5708.5 -2797
EPRS1 -3119 -4961.5 5365
FAU -398 -3107.5 -8957
GNMT 2034 2434.5 -1354
GSR 9101 10803.5 -2790
HNMT 8197 7247.5 1908
IARS1 -11385 -9604.5 1639
INMT 2215 -2585.5 5160
KARS1 -5243 -6572.5 5399
LARS1 -6075 -9820.5 8097
MARS1 -2525 4393.5 5205
PAPSS1 8889 10274.5 3358
PAPSS2 -2054 10893.5 12065
PSTK -9847 -6597.5 1548
QARS1 117 -2229.5 -8123
RARS1 -4667 -2320.5 10919
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SARS1 -5763 -4319.5 -6494
SCLY -7878 -8121.5 -4238
SECISBP2 -10159 -7413.5 11029
SEPHS2 7664 8171.5 -6365
SEPSECS -11044 -7942.5 10478
TXNRD1 8174 9744.5 -1886
UBA52 1062 -2813.5 -8649



Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

metric value
setSize 114
pMANOVA 1.41e-49
p.adjustMANOVA 8e-48
s.dist 0.866
s.t0_v_pod -0.199
s.pod_crp -0.533
s.t0_crp -0.653
p.t0_v_pod 0.000242
p.pod_crp 8e-23
p.t0_crp 1.47e-33




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CASC3 5229 8307.5 -4959
DCP1A -5323 -3532.5 5570
EIF4A3 7262 3109.5 -6695
EIF4G1 7959 10173.5 -4453
ETF1 7302 7893.5 7446
FAU -398 -3107.5 -8957
GSPT1 6476 -468.5 8999
GSPT2 -9786 -8638.5 -5866
MAGOH 986 -3633.5 -9031
MAGOHB -8802 -7937.5 4123
NCBP1 -5673 -2986.5 10640
NCBP2 -9305 -9742.5 9231
PABPC1 5341 171.5 4499
PNRC2 -4453 -3271.5 9604
PPP2CA 8179 7755.5 459
PPP2R1A 4621 5445.5 -8081
PPP2R2A 4161 2078.5 11871
RBM8A -7267 -1318.5 -6207
RNPS1 -11158 -7895.5 -4743
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SMG1 -4283 -2154.5 5353
SMG5 5302 4692.5 -4756
SMG6 -6108 -1314.5 -4879
SMG7 6604 9062.5 8106
SMG8 2917 3867.5 3272
SMG9 157 2091.5 -3119
UBA52 1062 -2813.5 -8649
UPF1 4686 7747.5 -4370
UPF2 977 1857.5 10188
UPF3A -9722 -7971.5 -903
UPF3B -8112 -4418.5 8297



Nonsense-Mediated Decay (NMD)

metric value
setSize 114
pMANOVA 1.41e-49
p.adjustMANOVA 8e-48
s.dist 0.866
s.t0_v_pod -0.199
s.pod_crp -0.533
s.t0_crp -0.653
p.t0_v_pod 0.000242
p.pod_crp 8e-23
p.t0_crp 1.47e-33




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CASC3 5229 8307.5 -4959
DCP1A -5323 -3532.5 5570
EIF4A3 7262 3109.5 -6695
EIF4G1 7959 10173.5 -4453
ETF1 7302 7893.5 7446
FAU -398 -3107.5 -8957
GSPT1 6476 -468.5 8999
GSPT2 -9786 -8638.5 -5866
MAGOH 986 -3633.5 -9031
MAGOHB -8802 -7937.5 4123
NCBP1 -5673 -2986.5 10640
NCBP2 -9305 -9742.5 9231
PABPC1 5341 171.5 4499
PNRC2 -4453 -3271.5 9604
PPP2CA 8179 7755.5 459
PPP2R1A 4621 5445.5 -8081
PPP2R2A 4161 2078.5 11871
RBM8A -7267 -1318.5 -6207
RNPS1 -11158 -7895.5 -4743
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SMG1 -4283 -2154.5 5353
SMG5 5302 4692.5 -4756
SMG6 -6108 -1314.5 -4879
SMG7 6604 9062.5 8106
SMG8 2917 3867.5 3272
SMG9 157 2091.5 -3119
UBA52 1062 -2813.5 -8649
UPF1 4686 7747.5 -4370
UPF2 977 1857.5 10188
UPF3A -9722 -7971.5 -903
UPF3B -8112 -4418.5 8297



PD-1 signaling

metric value
setSize 28
pMANOVA 2.25e-07
p.adjustMANOVA 1.89e-06
s.dist 0.863
s.t0_v_pod -0.578
s.pod_crp -0.592
s.t0_crp -0.246
p.t0_v_pod 1.19e-07
p.pod_crp 5.91e-08
p.t0_crp 0.0243




Gene pod_crp t0_v_pod
TRBC1 -9646.5 -11503
LCK -9943.5 -11140
HLA-DRA -9127.5 -11648
TRAC -9950.5 -10637
CD247 -8658.5 -11933
CD3E -9657.5 -10696
HLA-DPB1 -8520.5 -11842
TRBV12-3 -10084.5 -9947
HLA-DPA1 -8382.5 -11909
CD3G -8663.5 -11060
CD3D -8899.5 -10748
TRAV8-4 -10231.5 -9067
HLA-DQA1 -8064.5 -11408
HLA-DQB2 -9739.5 -9073
TRAV19 -9008.5 -9695
TRAV29DV5 -9622.5 -9017
TRBV7-9 -8367.5 -9246
CD274 -8795.5 -6569
HLA-DQA2 -8079.5 -4641
CD4 -7068.5 -5145

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CD247 -11933 -8658.5 -7294
CD274 -6569 -8795.5 4582
CD3D -10748 -8899.5 -1723
CD3E -10696 -9657.5 825
CD3G -11060 -8663.5 6100
CD4 -5145 -7068.5 -4207
CSK 5225 8794.5 -6733
HLA-DPA1 -11909 -8382.5 4327
HLA-DPB1 -11842 -8520.5 -3185
HLA-DQA1 -11408 -8064.5 4681
HLA-DQA2 -4641 -8079.5 -8418
HLA-DQB1 -5513 -6016.5 -1593
HLA-DQB2 -9073 -9739.5 -7013
HLA-DRA -11648 -9127.5 2478
HLA-DRB1 -7880 -1220.5 8149
HLA-DRB5 -4971 922.5 7335
LCK -11140 -9943.5 -7000
PDCD1 -6724 -4307.5 -3987
PDCD1LG2 -3221 -1659.5 10418
PTPN11 5322 7012.5 2127
PTPN6 6089 9872.5 -226
TRAC -10637 -9950.5 328
TRAV19 -9695 -9008.5 -3895
TRAV29DV5 -9017 -9622.5 -1671
TRAV8-4 -9067 -10231.5 -7960
TRBC1 -11503 -9646.5 -2158
TRBV12-3 -9947 -10084.5 -8593
TRBV7-9 -9246 -8367.5 -4513



Retrograde neurotrophin signalling

metric value
setSize 12
pMANOVA 0.000285
p.adjustMANOVA 0.00105
s.dist 0.856
s.t0_v_pod 0.566
s.pod_crp 0.559
s.t0_crp -0.316
p.t0_v_pod 0.000682
p.pod_crp 0.000799
p.t0_crp 0.0578




Gene t0_v_pod pod_crp
CLTC 8906 10209.5
AP2M1 8534 9148.5
AP2A1 6537 10946.5
AP2S1 7958 8636.5
CLTA 8272 8299.5
AP2A2 7253 9259.5
DNM2 6076 9608.5
DNM3 7062 6176.5
DNM1 3494 7051.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AP2A1 6537 10946.5 315
AP2A2 7253 9259.5 -7222
AP2B1 -2677 2779.5 -3730
AP2M1 8534 9148.5 -8293
AP2S1 7958 8636.5 -5676
CLTA 8272 8299.5 -3488
CLTC 8906 10209.5 776
DNAL4 3361 -1071.5 -8613
DNM1 3494 7051.5 11360
DNM2 6076 9608.5 -7117
DNM3 7062 6176.5 2676
NTRK1 -7521 -5181.5 7616



Formation of the ternary complex, and subsequently, the 43S complex

metric value
setSize 51
pMANOVA 7.74e-29
p.adjustMANOVA 2.77e-27
s.dist 0.855
s.t0_v_pod -0.0856
s.pod_crp -0.554
s.t0_crp -0.645
p.t0_v_pod 0.29
p.pod_crp 7.55e-12
p.t0_crp 1.5e-15




Gene t0_crp pod_crp
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPS27 -8998 -9300.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPS15A -8955 -8640.5
RPS16 -8966 -8515.5
RPS10 -9032 -8385.5
RPS20 -7998 -9180.5
RPS7 -8575 -8531.5
RPS17 -9077 -8041.5
RPS21 -9038 -7972.5
RPS11 -9014 -7986.5
RPS18 -8554 -8380.5
RPS28 -8958 -7992.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
FAU -398 -3107.5 -8957
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637



WNT5A-dependent internalization of FZD4

metric value
setSize 13
pMANOVA 7.41e-06
p.adjustMANOVA 4.18e-05
s.dist 0.848
s.t0_v_pod 0.448
s.pod_crp 0.54
s.t0_crp -0.477
p.t0_v_pod 0.00516
p.pod_crp 0.000752
p.t0_crp 0.00293




Gene pod_crp t0_crp
AP2M1 9148.5 -8293
CLTB 8327.5 -8415
AP2A2 9259.5 -7222
AP2S1 8636.5 -5676
ARRB2 10251.5 -4748
CLTA 8299.5 -3488
AP2B1 2779.5 -3730
PRKCB 9016.5 -815

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AP2A1 6537 10946.5 315
AP2A2 7253 9259.5 -7222
AP2B1 -2677 2779.5 -3730
AP2M1 8534 9148.5 -8293
AP2S1 7958 8636.5 -5676
ARRB2 8385 10251.5 -4748
CLTA 8272 8299.5 -3488
CLTB 6108 8327.5 -8415
CLTC 8906 10209.5 776
DVL2 -10415 -7512.5 -8214
FZD4 -11378 3277.5 7998
PRKCA 1153 -3131.5 -3930
PRKCB 6954 9016.5 -815



RHO GTPases Activate ROCKs

metric value
setSize 18
pMANOVA 5.18e-05
p.adjustMANOVA 0.000232
s.dist 0.848
s.t0_v_pod 0.539
s.pod_crp 0.644
s.t0_crp 0.113
p.t0_v_pod 7.45e-05
p.pod_crp 2.2e-06
p.t0_crp 0.408




Gene pod_crp t0_v_pod
MYL6 10014.5 8547
CFL1 9826.5 8115
RHOA 9816.5 8091
PAK1 9588.5 8124
LIMK2 8567.5 8063
ROCK1 9040.5 7336
MYH9 8971.5 6678
PPP1CB 7433.5 6990
PPP1R12A 8180.5 6046
ROCK2 6998.5 6064
MYL9 5473.5 7605
LIMK1 8079.5 4690
MYL12B 6824.5 5119
RHOB 7482.5 1180
PPP1R12B 5119.5 1724
MYH10 6149.5 658

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CFL1 8115 9826.5 -6350
LIMK1 4690 8079.5 -3541
LIMK2 8063 8567.5 -3615
MYH10 658 6149.5 5118
MYH11 -3387 -3208.5 5759
MYH9 6678 8971.5 -4854
MYL12B 5119 6824.5 -2978
MYL6 8547 10014.5 -8390
MYL9 7605 5473.5 4521
PAK1 8124 9588.5 9318
PPP1CB 6990 7433.5 9292
PPP1R12A 6046 8180.5 9594
PPP1R12B 1724 5119.5 994
RHOA 8091 9816.5 4832
RHOB 1180 7482.5 6800
RHOC -10985 5823.5 2631
ROCK1 7336 9040.5 11587
ROCK2 6064 6998.5 9646



Unwinding of DNA

metric value
setSize 12
pMANOVA 0.00167
p.adjustMANOVA 0.00491
s.dist 0.846
s.t0_v_pod -0.647
s.pod_crp -0.536
s.t0_crp -0.0935
p.t0_v_pod 0.000104
p.pod_crp 0.00129
p.t0_crp 0.575




Gene t0_v_pod pod_crp
MCM3 -11802 -9993.5
MCM7 -11645 -9709.5
GINS4 -10060 -7766.5
MCM6 -9616 -7523.5
MCM8 -10645 -6256.5
MCM4 -8518 -6453.5
GINS3 -10188 -5352.5
MCM2 -7064 -6228.5
MCM5 -7172 -2261.5
CDC45 -2615 -3919.5
GINS2 -4688 -2051.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CDC45 -2615 -3919.5 2286
GINS1 -4295 2947.5 7784
GINS2 -4688 -2051.5 3425
GINS3 -10188 -5352.5 1452
GINS4 -10060 -7766.5 4198
MCM2 -7064 -6228.5 -4440
MCM3 -11802 -9993.5 -4964
MCM4 -8518 -6453.5 3033
MCM5 -7172 -2261.5 -6004
MCM6 -9616 -7523.5 1545
MCM7 -11645 -9709.5 -5017
MCM8 -10645 -6256.5 3870



SRP-dependent cotranslational protein targeting to membrane

metric value
setSize 111
pMANOVA 1.84e-50
p.adjustMANOVA 1.13e-48
s.dist 0.843
s.t0_v_pod -0.137
s.pod_crp -0.504
s.t0_crp -0.662
p.t0_v_pod 0.0126
p.pod_crp 4.08e-20
p.t0_crp 1.55e-33




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
DDOST 6872 8730.5 -8216
FAU -398 -3107.5 -8957
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPN1 7889 8297.5 -3585
RPN2 7031 9081.5 1340
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SEC11A 7873 8132.5 -1837
SEC11C -8643 -6713.5 7156
SEC61A1 6426 7605.5 -999
SEC61A2 -10531 -6002.5 6309
SEC61B 7021 5404.5 -8509
SEC61G 4782 100.5 6114
SPCS1 3073 215.5 -4082
SPCS2 3246 765.5 5988
SPCS3 4354 2405.5 9956
SRP14 6321 6875.5 408
SRP19 4277 2607.5 11301
SRP54 6585 7880.5 11591
SRP68 2027 1403.5 -1273
SRP72 -1463 -2052.5 4765
SRP9 4470 -335.5 3901
SRPRA 5046 8209.5 -2491
SRPRB -9150 -7798.5 2097
SSR1 6548 3297.5 4156
SSR2 2817 -1507.5 -6358
SSR3 5935 4737.5 5920
SSR4 3141 1313.5 -6887
TRAM1 -4500 -4292.5 8749
UBA52 1062 -2813.5 -8649



Gap junction trafficking

metric value
setSize 13
pMANOVA 0.000238
p.adjustMANOVA 9e-04
s.dist 0.842
s.t0_v_pod 0.559
s.pod_crp 0.567
s.t0_crp -0.272
p.t0_v_pod 0.000481
p.pod_crp 0.000397
p.t0_crp 0.0895




Gene pod_crp t0_v_pod
CLTC 10209.5 8906
DAB2 10537.5 8131
CLTCL1 9589.5 8793
GJD3 10395.5 7930
AP2M1 9148.5 8534
CLTA 8299.5 8272
DNM2 9608.5 6076
CLTB 8327.5 6108
DNM1 7051.5 3494
GJB6 2566.5 4772
GJC1 4623.5 533

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AP2M1 8534 9148.5 -8293
CLTA 8272 8299.5 -3488
CLTB 6108 8327.5 -8415
CLTC 8906 10209.5 776
CLTCL1 8793 9589.5 -43
DAB2 8131 10537.5 -6861
DNM1 3494 7051.5 11360
DNM2 6076 9608.5 -7117
GJB6 4772 2566.5 -8537
GJC1 533 4623.5 5790
GJC2 657 -3126.5 -6975
GJD3 7930 10395.5 7557
MYO6 -11169 -3894.5 7217



RHO GTPases Activate WASPs and WAVEs

metric value
setSize 35
pMANOVA 1.97e-09
p.adjustMANOVA 2.07e-08
s.dist 0.839
s.t0_v_pod 0.606
s.pod_crp 0.575
s.t0_crp -0.0811
p.t0_v_pod 5.5e-10
p.pod_crp 3.9e-09
p.t0_crp 0.407




Gene t0_v_pod pod_crp
WASF1 9405 10814.5
GRB2 9164 10574.5
ARPC1B 9147 10576.5
ARPC1A 8777 10679.5
ACTB 8910 10467.5
CYFIP1 9115 10172.5
RAC1 8578 10538.5
WASF2 8243 10583.5
ARPC5 8514 10217.5
WAS 8460 10250.5
ACTG1 8532 9603.5
NCKAP1L 7406 10931.5
MAPK1 7410 10809.5
MAPK3 8928 8957.5
ARPC3 8180 9265.5
BTK 7051 10605.5
ARPC4 7492 9663.5
ACTR2 7711 9342.5
ACTR3 7769 9118.5
ARPC2 7340 9318.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ABI1 7049 9291.5 9245
ABI2 -10551 -8583.5 3003
ABL1 228 5682.5 -5081
ACTB 8910 10467.5 -889
ACTG1 8532 9603.5 -7489
ACTR2 7711 9342.5 8628
ACTR3 7769 9118.5 4171
ARPC1A 8777 10679.5 4453
ARPC1B 9147 10576.5 -5950
ARPC2 7340 9318.5 1060
ARPC3 8180 9265.5 5269
ARPC4 7492 9663.5 -3661
ARPC5 8514 10217.5 7082
BAIAP2 -179 -2720.5 -4504
BRK1 6982 3536.5 -8786
BTK 7051 10605.5 9588
CDC42 7428 8935.5 7768
CYFIP1 9115 10172.5 -922
CYFIP2 -10053 -3055.5 -1427
GRB2 9164 10574.5 -1296
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
NCK1 -11136 -9019.5 160
NCKAP1 7451 9142.5 4841
NCKAP1L 7406 10931.5 6276
NCKIPSD 318 -4444.5 -7961
PTK2 4461 -229.5 1108
RAC1 8578 10538.5 7795
WAS 8460 10250.5 -538
WASF1 9405 10814.5 -3414
WASF2 8243 10583.5 -331
WASF3 6817 2690.5 -2404
WASL 282 1511.5 5487
WIPF1 576 2692.5 -2749
WIPF2 5695 9073.5 5444



p130Cas linkage to MAPK signaling for integrins

metric value
setSize 11
pMANOVA 0.0017
p.adjustMANOVA 0.00494
s.dist 0.833
s.t0_v_pod 0.663
s.pod_crp 0.49
s.t0_crp 0.113
p.t0_v_pod 0.000139
p.pod_crp 0.00486
p.t0_crp 0.515




Gene t0_v_pod pod_crp
CRK 8795 10204.5
APBB1IP 8705 10254.5
TLN1 8420 10166.5
ITGA2B 8796 8441.5
RAP1A 7212 8328.5
ITGB3 8237 5495.5
VWF 6516 5703.5
RAP1B 3302 8354.5
FN1 8165 315.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
APBB1IP 8705 10254.5 -854
CRK 8795 10204.5 6988
FN1 8165 315.5 9070
ITGA2B 8796 8441.5 2223
ITGB3 8237 5495.5 -2482
PTK2 4461 -229.5 1108
RAP1A 7212 8328.5 9770
RAP1B 3302 8354.5 8566
SRC -8705 -5564.5 1869
TLN1 8420 10166.5 -4313
VWF 6516 5703.5 -1068



Influenza Viral RNA Transcription and Replication

metric value
setSize 135
pMANOVA 6.97e-51
p.adjustMANOVA 4.51e-49
s.dist 0.828
s.t0_v_pod -0.228
s.pod_crp -0.529
s.t0_crp -0.595
p.t0_v_pod 4.82e-06
p.pod_crp 2.38e-26
p.t0_crp 5.68e-33




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AAAS -8054 -4779.5 -4358
DNAJC3 8337 9705.5 7588
FAU -398 -3107.5 -8957
GRSF1 5173 108.5 1948
GTF2F1 4984 6928.5 -7059
GTF2F2 5437 7006.5 1993
HSP90AA1 1338 -1973.5 6514
IPO5 -10340 -10292.5 -2989
NDC1 -11752 -10241.5 283
NUP107 -10234 -8189.5 9188
NUP133 -7569 -5650.5 1394
NUP153 -6117 -1929.5 635
NUP155 -9959 -7484.5 4716
NUP160 -10049 -9039.5 3294
NUP188 -11192 -8612.5 -4784
NUP205 -10902 -8251.5 -205
NUP210 -10387 -5194.5 -5639
NUP214 7891 9278.5 1996
NUP35 -9876 -10046.5 -2752
NUP37 3126 366.5 -1383
NUP42 -5434 -3311.5 10712
NUP43 -9276 -8527.5 9596
NUP50 4499 4003.5 9103
NUP54 -8230 -7581.5 11428
NUP58 8727 9397.5 8050
NUP62 765 -3073.5 -3415
NUP85 -2996 -3252.5 4188
NUP88 -10700 -10009.5 -1806
NUP93 -11346 -5296.5 9018
NUP98 3098 4012.5 229
PARP1 -11233 -8989.5 -6608
POLR2A -3022 6845.5 143
POLR2B -2474 -2457.5 1585
POLR2C 1518 -1408.5 -7182
POLR2D -3931 -5787.5 4203
POLR2E 7547 6080.5 -8394
POLR2F 4598 4075.5 -8724
POLR2G 3548 4752.5 -8433
POLR2H -2745 -6952.5 -7995
POLR2I 314 -3631.5 -8535
POLR2J 6675 5210.5 -8301
POLR2K -1760 -3462.5 5197
POLR2L 5301 2246.5 -9054
POM121 -7980 -2823.5 -4677
POM121C -7053 -1781.5 -5828
RAE1 5094 3686.5 -928
RANBP2 -801 -2038.5 7972
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SEC13 5745 6316.5 -5667
SEH1L -5760 -9805.5 6177
TPR -6856 -4470.5 9152
UBA52 1062 -2813.5 -8649



NOTCH4 Activation and Transmission of Signal to the Nucleus

metric value
setSize 10
pMANOVA 0.00854
p.adjustMANOVA 0.0196
s.dist 0.82
s.t0_v_pod 0.521
s.pod_crp 0.623
s.t0_crp 0.11
p.t0_v_pod 0.00432
p.pod_crp 0.000641
p.t0_crp 0.548




Gene pod_crp t0_v_pod
NCSTN 11024.5 8989
ADAM10 10024.5 8563
PSEN1 10233.5 7727
JAG1 8582.5 8522
APH1B 9234.5 6161
PSENEN 6902.5 5758
YWHAZ 6696.5 5617
APH1A 3829.5 4159

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ADAM10 8563 10024.5 6883
APH1A 4159 3829.5 -8132
APH1B 6161 9234.5 10178
JAG1 8522 8582.5 -906
NCSTN 8989 11024.5 4632
NOTCH4 -5029 9448.5 2737
PSEN1 7727 10233.5 8327
PSEN2 -7574 -5874.5 1369
PSENEN 5758 6902.5 -3982
YWHAZ 5617 6696.5 6589



Platelet sensitization by LDL

metric value
setSize 16
pMANOVA 0.000363
p.adjustMANOVA 0.0013
s.dist 0.814
s.t0_v_pod 0.551
s.pod_crp 0.6
s.t0_crp 0.00436
p.t0_v_pod 0.000137
p.pod_crp 3.25e-05
p.t0_crp 0.976




Gene pod_crp t0_v_pod
MAPK14 10677.5 9065
FGR 10927.5 8267
PLA2G4A 9775.5 9079
PECAM1 10271.5 7628
PPP2CA 7755.5 8179
PPP2CB 8182.5 7654
PTPN6 9872.5 6089
PPP2R5B 8678.5 6774
PPP2R5A 9346.5 5905
LRP8 8622.5 4572
PTPN11 7012.5 5322
PPP2R1A 5445.5 4621
PPP2R5D 6108.5 2423

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
FGR 8267 10927.5 360
LRP8 4572 8622.5 1311
MAPK14 9065 10677.5 1318
PECAM1 7628 10271.5 6038
PLA2G4A 9079 9775.5 2589
PPP2CA 8179 7755.5 459
PPP2CB 7654 8182.5 4467
PPP2R1A 4621 5445.5 -8081
PPP2R1B -246 -79.5 4856
PPP2R5A 5905 9346.5 6270
PPP2R5B 6774 8678.5 567
PPP2R5C -11063 -4456.5 3075
PPP2R5D 2423 6108.5 -4168
PPP2R5E -621 -12.5 5320
PTPN11 5322 7012.5 2127
PTPN6 6089 9872.5 -226



Major pathway of rRNA processing in the nucleolus and cytosol

metric value
setSize 180
pMANOVA 8.4e-59
p.adjustMANOVA 7.14e-57
s.dist 0.808
s.t0_v_pod -0.309
s.pod_crp -0.581
s.t0_crp -0.468
p.t0_v_pod 8.81e-13
p.pod_crp 2e-41
p.t0_crp 1.92e-27




Gene pod_crp t0_crp
FBL -10014.5 -9029
RPL3 -9970.5 -8984
RPL14 -9780.5 -8971
RPS27A -9698.5 -9022
RPS25 -9664.5 -8793
RPLP2 -9244.5 -9085
RPS27 -9300.5 -8998
RPL5 -9893.5 -8450
RPS6 -9602.5 -8694
RPS2 -9114.5 -9084
RPS3 -9149.5 -9021
RPL32 -9346.5 -8747
RPS12 -9016.5 -9041
RPS5 -9110.5 -8931
RPL7 -9317.5 -8731
RPS29 -8819.5 -9075
RPS23 -9063.5 -8770
WDR46 -9002.5 -8805
RPL23A -10055.5 -7855
RPL30 -8740.5 -8940

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BMS1 -11259 -9837.5 -3049
BOP1 -5067 -6215.5 -8182
BYSL -4260 -5812.5 -8348
C1D 3589 2173.5 10355
CSNK1D 2397 6982.5 -7878
CSNK1E -9907 -7297.5 -6962
DCAF13 -5439 -6161.5 -1571
DDX21 3105 1476.5 10298
DDX47 -10803 -9741.5 3472
DDX49 4883 4133.5 -7546
DDX52 497 2715.5 12255
DHX37 -8019 -5530.5 -4867
DIS3 -4223 -3621.5 11499
EBNA1BP2 -4046 -6622.5 -4968
EMG1 -9832 -8867.5 2684
ERI1 5530 7049.5 11839
EXOSC1 -964 324.5 4024
EXOSC10 -11064 -7501.5 4924
EXOSC2 -10523 -10042.5 -6551
EXOSC3 484 -344.5 1768
EXOSC4 7666 9691.5 -6570
EXOSC5 -4274 -8642.5 -7815
EXOSC6 -9683 -5334.5 -73
EXOSC7 -10418 -8248.5 -8749
EXOSC8 -10978 -9706.5 2811
EXOSC9 -10090 -8249.5 9499
FAU -398 -3107.5 -8957
FBL -9778 -10014.5 -9029
FCF1 4510 2971.5 3971
FTSJ3 -3832 131.5 174
GNL3 -8083 -10106.5 1676
HEATR1 -9924 -8126.5 2205
IMP3 -8978 -7554.5 -7770
IMP4 -10341 -8253.5 -8102
ISG20L2 3807 4583.5 4556
KRR1 -8302 -8139.5 6121
LAS1L -11837 -9902.5 -5801
LTV1 -4115 -7205.5 2005
MPHOSPH10 -7610 -8478.5 11201
MPHOSPH6 2229 -670.5 3568
MTREX -2587 -3781.5 5798
NCL -9079 -8956.5 -5195
NIP7 -5758 -6840.5 1638
NOB1 -10031 -8712.5 -7293
NOC4L -5327 1541.5 2328
NOL11 -9893 -10169.5 3608
NOL12 4909 2843.5 -5893
NOL6 -10505 -8619.5 -4953
NOL9 -9870 -9196.5 7645
NOP14 -10583 -9836.5 -4349
NOP56 -11150 -9853.5 -4229
NOP58 -9707 -10146.5 7541
PDCD11 -11196 -6754.5 -5153
PELP1 -10500 -8949.5 -3822
PES1 -1986 -5090.5 -8225
PNO1 -6716 -6607.5 9516
PWP2 -979 -537.5 -2293
RBM28 -11328 -6684.5 -67
RCL1 -827 -7181.5 -4488
RIOK1 -3673 -5171.5 1250
RIOK2 938 -7112.5 9609
RIOK3 8613 7808.5 11605
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPP14 3083 342.5 5701
RPP21 -5058 -5368.5 -8141
RPP25 -8062 -8272.5 -4531
RPP30 -7922 -8271.5 6663
RPP38 -6620 -8456.5 3602
RPP40 -4570 -10208.5 3149
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
RRP1 -3035 -2655.5 4041
RRP36 -1483 2381.5 -3338
RRP7A -2752 -3730.5 -4140
RRP9 -9725 -8788.5 -8383
SENP3 3004 -1009.5 -3512
SNORD3A -2249 9350.5 9071
SNU13 -6683 -8010.5 -8297
TBL3 -3372 -617.5 -6850
TEX10 -9534 -8892.5 10010
TSR1 -9314 -9987.5 2103
UBA52 1062 -2813.5 -8649
UTP11 4659 2445.5 5799
UTP14A -1765 -1115.5 2230
UTP14C -1614 1103.5 7508
UTP15 -10212 -9487.5 9817
UTP18 5105 3913.5 584
UTP20 -10098 -8186.5 7274
UTP3 -2864 -4281.5 -5024
UTP4 -11042 -9930.5 -146
UTP6 -4379 -8202.5 5491
WDR12 5227 1380.5 4923
WDR18 -2350 -3255.5 -5475
WDR3 -6376 -7406.5 -927
WDR36 -3725 -5865.5 4916
WDR43 -7301 -9654.5 -1341
WDR46 -10704 -9002.5 -8805
WDR75 -9487 -10092.5 7131
XRN2 9257 10133.5 538



rRNA processing in the nucleus and cytosol

metric value
setSize 190
pMANOVA 1.37e-61
p.adjustMANOVA 1.55e-59
s.dist 0.808
s.t0_v_pod -0.309
s.pod_crp -0.578
s.t0_crp -0.471
p.t0_v_pod 1.87e-13
p.pod_crp 3.52e-43
p.t0_crp 3.59e-29




Gene pod_crp t0_crp
FBL -10014.5 -9029
RPL3 -9970.5 -8984
RPL14 -9780.5 -8971
RPS27A -9698.5 -9022
RPS25 -9664.5 -8793
RPLP2 -9244.5 -9085
RPS27 -9300.5 -8998
RPL5 -9893.5 -8450
RPS6 -9602.5 -8694
RPS2 -9114.5 -9084
RPS3 -9149.5 -9021
RPL32 -9346.5 -8747
RPS12 -9016.5 -9041
RPS5 -9110.5 -8931
RPL7 -9317.5 -8731
RPS29 -8819.5 -9075
RPS23 -9063.5 -8770
WDR46 -9002.5 -8805
RPL23A -10055.5 -7855
RPL30 -8740.5 -8940

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BMS1 -11259 -9837.5 -3049
BOP1 -5067 -6215.5 -8182
BYSL -4260 -5812.5 -8348
C1D 3589 2173.5 10355
CSNK1D 2397 6982.5 -7878
CSNK1E -9907 -7297.5 -6962
DCAF13 -5439 -6161.5 -1571
DDX21 3105 1476.5 10298
DDX47 -10803 -9741.5 3472
DDX49 4883 4133.5 -7546
DDX52 497 2715.5 12255
DHX37 -8019 -5530.5 -4867
DIMT1 -7807 -9429.5 8033
DIS3 -4223 -3621.5 11499
DKC1 -11128 -10321.5 -4947
EBNA1BP2 -4046 -6622.5 -4968
EMG1 -9832 -8867.5 2684
ERI1 5530 7049.5 11839
EXOSC1 -964 324.5 4024
EXOSC10 -11064 -7501.5 4924
EXOSC2 -10523 -10042.5 -6551
EXOSC3 484 -344.5 1768
EXOSC4 7666 9691.5 -6570
EXOSC5 -4274 -8642.5 -7815
EXOSC6 -9683 -5334.5 -73
EXOSC7 -10418 -8248.5 -8749
EXOSC8 -10978 -9706.5 2811
EXOSC9 -10090 -8249.5 9499
FAU -398 -3107.5 -8957
FBL -9778 -10014.5 -9029
FCF1 4510 2971.5 3971
FTSJ3 -3832 131.5 174
GAR1 -6778 -6732.5 -2718
GNL3 -8083 -10106.5 1676
HEATR1 -9924 -8126.5 2205
IMP3 -8978 -7554.5 -7770
IMP4 -10341 -8253.5 -8102
ISG20L2 3807 4583.5 4556
KRR1 -8302 -8139.5 6121
LAS1L -11837 -9902.5 -5801
LTV1 -4115 -7205.5 2005
MPHOSPH10 -7610 -8478.5 11201
MPHOSPH6 2229 -670.5 3568
MTREX -2587 -3781.5 5798
NAT10 -11508 -10101.5 -4796
NCL -9079 -8956.5 -5195
NHP2 -3395 -6371.5 -8264
NIP7 -5758 -6840.5 1638
NOB1 -10031 -8712.5 -7293
NOC4L -5327 1541.5 2328
NOL11 -9893 -10169.5 3608
NOL12 4909 2843.5 -5893
NOL6 -10505 -8619.5 -4953
NOL9 -9870 -9196.5 7645
NOP10 8331 9945.5 -7324
NOP14 -10583 -9836.5 -4349
NOP2 -9186 -9188.5 -7692
NOP56 -11150 -9853.5 -4229
NOP58 -9707 -10146.5 7541
PDCD11 -11196 -6754.5 -5153
PELP1 -10500 -8949.5 -3822
PES1 -1986 -5090.5 -8225
PNO1 -6716 -6607.5 9516
PWP2 -979 -537.5 -2293
RBM28 -11328 -6684.5 -67
RCL1 -827 -7181.5 -4488
RIOK1 -3673 -5171.5 1250
RIOK2 938 -7112.5 9609
RIOK3 8613 7808.5 11605
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPP14 3083 342.5 5701
RPP21 -5058 -5368.5 -8141
RPP25 -8062 -8272.5 -4531
RPP30 -7922 -8271.5 6663
RPP38 -6620 -8456.5 3602
RPP40 -4570 -10208.5 3149
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
RRP1 -3035 -2655.5 4041
RRP36 -1483 2381.5 -3338
RRP7A -2752 -3730.5 -4140
RRP9 -9725 -8788.5 -8383
SENP3 3004 -1009.5 -3512
SNORD3A -2249 9350.5 9071
SNU13 -6683 -8010.5 -8297
TBL3 -3372 -617.5 -6850
TEX10 -9534 -8892.5 10010
THUMPD1 -9539 -9971.5 7205
TRMT112 581 -2621.5 -9010
TSR1 -9314 -9987.5 2103
TSR3 3871 3345.5 -8960
UBA52 1062 -2813.5 -8649
UTP11 4659 2445.5 5799
UTP14A -1765 -1115.5 2230
UTP14C -1614 1103.5 7508
UTP15 -10212 -9487.5 9817
UTP18 5105 3913.5 584
UTP20 -10098 -8186.5 7274
UTP3 -2864 -4281.5 -5024
UTP4 -11042 -9930.5 -146
UTP6 -4379 -8202.5 5491
WDR12 5227 1380.5 4923
WDR18 -2350 -3255.5 -5475
WDR3 -6376 -7406.5 -927
WDR36 -3725 -5865.5 4916
WDR43 -7301 -9654.5 -1341
WDR46 -10704 -9002.5 -8805
WDR75 -9487 -10092.5 7131
XRN2 9257 10133.5 538



PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

metric value
setSize 13
pMANOVA 0.00379
p.adjustMANOVA 0.00983
s.dist 0.792
s.t0_v_pod 0.554
s.pod_crp 0.563
s.t0_crp 0.0616
p.t0_v_pod 0.000547
p.pod_crp 0.000438
p.t0_crp 0.701




Gene pod_crp t0_v_pod
RAC1 10538.5 8578
CRK 10204.5 8795
RHOA 9816.5 8091
PXN 9442.5 6244
DOCK1 7702.5 7306
PTK6 8429.5 5918
ELMO2 9915.5 4462
ELMO1 5699.5 6236
NRAS 6249.5 5348
KRAS 6438.5 3723
RASA1 5191.5 2120

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ARHGAP35 -3310 -864.5 -7174
CRK 8795 10204.5 6988
DOCK1 7306 7702.5 -3489
ELMO1 6236 5699.5 -4053
ELMO2 4462 9915.5 2925
HRAS -3240 -6003.5 -7632
KRAS 3723 6438.5 11041
NRAS 5348 6249.5 9510
PTK6 5918 8429.5 4058
PXN 6244 9442.5 -6596
RAC1 8578 10538.5 7795
RASA1 2120 5191.5 11098
RHOA 8091 9816.5 4832



Phosphorylation of CD3 and TCR zeta chains

metric value
setSize 27
pMANOVA 4.43e-06
p.adjustMANOVA 2.71e-05
s.dist 0.784
s.t0_v_pod -0.541
s.pod_crp -0.514
s.t0_crp -0.24
p.t0_v_pod 1.12e-06
p.pod_crp 3.72e-06
p.t0_crp 0.0308




Gene t0_v_pod pod_crp
TRBC1 -11503 -9646.5
LCK -11140 -9943.5
HLA-DRA -11648 -9127.5
TRAC -10637 -9950.5
CD247 -11933 -8658.5
CD3E -10696 -9657.5
HLA-DPB1 -11842 -8520.5
TRBV12-3 -9947 -10084.5
HLA-DPA1 -11909 -8382.5
CD3G -11060 -8663.5
CD3D -10748 -8899.5
TRAV8-4 -9067 -10231.5
HLA-DQA1 -11408 -8064.5
HLA-DQB2 -9073 -9739.5
TRAV19 -9695 -9008.5
TRAV29DV5 -9017 -9622.5
TRBV7-9 -9246 -8367.5
HLA-DQA2 -4641 -8079.5
CD4 -5145 -7068.5
HLA-DQB1 -5513 -6016.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CD247 -11933 -8658.5 -7294
CD3D -10748 -8899.5 -1723
CD3E -10696 -9657.5 825
CD3G -11060 -8663.5 6100
CD4 -5145 -7068.5 -4207
CSK 5225 8794.5 -6733
HLA-DPA1 -11909 -8382.5 4327
HLA-DPB1 -11842 -8520.5 -3185
HLA-DQA1 -11408 -8064.5 4681
HLA-DQA2 -4641 -8079.5 -8418
HLA-DQB1 -5513 -6016.5 -1593
HLA-DQB2 -9073 -9739.5 -7013
HLA-DRA -11648 -9127.5 2478
HLA-DRB1 -7880 -1220.5 8149
HLA-DRB5 -4971 922.5 7335
LCK -11140 -9943.5 -7000
PAG1 4049 6401.5 1206
PTPN22 -1098 6754.5 8059
PTPRC 2238 7074.5 9361
PTPRJ 7717 10192.5 -3019
TRAC -10637 -9950.5 328
TRAV19 -9695 -9008.5 -3895
TRAV29DV5 -9017 -9622.5 -1671
TRAV8-4 -9067 -10231.5 -7960
TRBC1 -11503 -9646.5 -2158
TRBV12-3 -9947 -10084.5 -8593
TRBV7-9 -9246 -8367.5 -4513



DNA methylation

metric value
setSize 20
pMANOVA 7.8e-07
p.adjustMANOVA 6.01e-06
s.dist 0.784
s.t0_v_pod 0.521
s.pod_crp 0.356
s.t0_crp -0.466
p.t0_v_pod 5.45e-05
p.pod_crp 0.00586
p.t0_crp 0.000312




Gene t0_v_pod t0_crp
H2BC12 9025.0 -7638.0
H2AJ 9260.0 -7169.0
H2AZ1 6041.0 -8638.0
H2BC5 8040.0 -4891.0
H3C15 6686.5 -5402.5
H2BC11 7954.0 -4404.0
H2BC15 5393.0 -4378.0
H2AC6 7948.0 -2700.0
H2BC21 9211.0 -2181.0
H2BC17 7392.0 -2437.0
H2BC9 5396.0 -2834.0
DNMT3B 4306.0 -2993.0
H2BC4 7438.0 -575.0

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
DNMT1 -11831.0 -9832.5 -5608.0
DNMT3A -2740.0 -4825.5 -6993.0
DNMT3B 4306.0 3574.5 -2993.0
H2AC20 4981.0 7901.5 3484.0
H2AC6 7948.0 6588.5 -2700.0
H2AJ 9260.0 11022.5 -7169.0
H2AZ1 6041.0 5160.5 -8638.0
H2AZ2 -1249.0 -3740.5 -7449.0
H2BC11 7954.0 7009.5 -4404.0
H2BC12 9025.0 8965.5 -7638.0
H2BC15 5393.0 5254.5 -4378.0
H2BC17 7392.0 6731.5 -2437.0
H2BC21 9211.0 9169.5 -2181.0
H2BC4 7438.0 8876.5 -575.0
H2BC5 8040.0 7278.5 -4891.0
H2BC9 5396.0 -3277.5 -2834.0
H2BU1 -6302.0 -1745.5 -1518.0
H3-3A 8612.0 9279.5 1082.0
H3C15 6686.5 6812.0 -5402.5
UHRF1 176.0 2812.5 5711.0



Neutrophil degranulation

metric value
setSize 458
pMANOVA 2.96e-111
p.adjustMANOVA 4.02e-108
s.dist 0.784
s.t0_v_pod 0.585
s.pod_crp 0.507
s.t0_crp -0.125
p.t0_v_pod 4.38e-103
p.pod_crp 8.68e-78
p.t0_crp 4.92e-06




Gene t0_v_pod pod_crp
IDH1 9386 11012.5
SIRPA 9389 10999.5
MCEMP1 9397 10953.5
CR1 9384 10938.5
HP 9357 10960.5
S100A12 9404 10844.5
RNASE2 9398 10847.5
DOK3 9278 10983.5
HK3 9267 10991.5
CTSD 9315 10929.5
S100A8 9399 10822.5
SIGLEC9 9251 10969.5
TIMP2 9328 10875.5
SERPINB1 9306 10852.5
GNS 9153 11008.5
CD63 9173 10978.5
ITGAM 9293 10834.5
ATP6V0A1 9323 10787.5
PGAM1 9318 10790.5
QSOX1 9146 10984.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
A1BG 5549 -1021.5 -9043
ABCA13 4679 -3246.5 5012
ACAA1 8268 10442.5 -4182
ACLY 5155 9990.5 367
ACTR10 7539 7788.5 5184
ACTR1B -10034 -6900.5 -8557
ACTR2 7711 9342.5 8628
ADAM10 8563 10024.5 6883
ADAM8 5639 7876.5 -6263
ADGRE3 392 569.5 -5684
ADGRE5 -2439 8886.5 3726
ADGRG3 8287 10581.5 -232
AGA -4259 -3941.5 -7193
AGL -3091 -451.5 6847
AGPAT2 9131 10752.5 -6100
ALAD 8468 9905.5 -6547
ALDH3B1 8358 10770.5 4819
ALDOA 9119 10582.5 -2211
ALDOC -3248 -6227.5 -2299
ALOX5 8938 10652.5 -46
AMPD3 8698 9842.5 -5014
ANO6 7885 5691.5 2377
ANPEP 9269 10553.5 -4906
ANXA2 8294 10557.5 5142
AOC1 6440 1211.5 -8838
AP1M1 6694 9387.5 -7850
AP2A2 7253 9259.5 -7222
APAF1 8922 8887.5 4682
APEH 1052 5550.5 -6878
APRT -2698 -7221.5 -8978
ARG1 8750 9690.5 5679
ARHGAP9 6200 7954.5 -7870
ARL8A 8176 9873.5 -6078
ARMC8 6350 4968.5 7456
ARPC5 8514 10217.5 7082
ARSA 3467 7245.5 5427
ARSB 7266 9894.5 8076
ASAH1 8238 10558.5 8611
ATAD3B -9611 -8807.5 -6464
ATG7 7943 6876.5 1008
ATP11A 8301 10203.5 2327
ATP11B 6085 7997.5 2603
ATP6AP2 7815 7261.5 4645
ATP6V0A1 9323 10787.5 -2130
ATP6V0C 8963 10683.5 22
ATP6V1D 8968 9974.5 1966
ATP8A1 -11424 -9554.5 -1718
ATP8B4 6939 7275.5 529
AZU1 5315 -4945.5 3365
B2M -6777 -5706.5 6159
B4GALT1 4312 8310.5 -4129
BIN2 5722 9453.5 -5737
BPI 6447 -373.5 4994
BRI3 8914 10628.5 -2556
BST1 9368 10384.5 -250
BST2 -7273 -823.5 8172
C3 -11882 -2637.5 7142
C3AR1 7945 10918.5 12042
C5AR1 9051 10635.5 -2311
C6orf120 6180 5301.5 -2375
CAB39 8234 9285.5 1886
CAMP 4662 -7302.5 1714
CAND1 -6331 -7247.5 4847
CANT1 7710 8684.5 -4576
CAP1 8073 9747.5 -1095
CAPN1 8476 10417.5 -5696
CAT 8987 10088.5 3197
CCT2 -8428 -10162.5 -1566
CCT8 6549 -257.5 -417
CD14 9013 9117.5 -5241
CD177 9378 10579.5 -5717
CD300A -2031 9671.5 7193
CD33 8005 6822.5 1099
CD36 9326 10630.5 3514
CD44 8185 9369.5 -1635
CD47 -11751 -9259.5 8957
CD53 7820 10049.5 71
CD55 9006 10695.5 5616
CD58 6573 9345.5 9406
CD59 5885 4869.5 -5821
CD63 9173 10978.5 -6690
CD68 8291 10367.5 1618
CD93 9379 10604.5 -5108
CDA 9217 10465.5 -3015
CDK13 -8244 1272.5 -2339
CEACAM1 6932 5764.5 7536
CEACAM3 6860 10056.5 7214
CEACAM6 4669 -387.5 6123
CEACAM8 4878 -824.5 -1005
CEP290 -9037 -7705.5 12023
CFD 2002 -1078.5 -2546
CFP 7122 9235.5 -2298
CHI3L1 -628 -5074.5 492
CHIT1 6077 2953.5 2585
CKAP4 9262 10505.5 2113
CLEC12A 4520 2910.5 5640
CLEC4C -11506 2215.5 3271
CLEC4D 9003 10335.5 9207
CLEC5A 8440 7723.5 -1588
CMTM6 7702 9512.5 10024
CNN2 6625 8027.5 -5208
COMMD3 -1418 -2597.5 484
COMMD9 7793 8005.5 3668
COPB1 7292 8174.5 6690
COTL1 7634 10318.5 4684
CPNE1 -3324 -2669.5 -8031
CPNE3 5876 5176.5 1654
CPPED1 8147 9837.5 5106
CR1 9384 10938.5 -2977
CRACR2A -8870 -560.5 -6440
CREG1 9360 9414.5 -4143
CRISP3 7441 1249.5 6153
CRISPLD2 8872 10488.5 6576
CSNK2B 3948 5702.5 -125
CST3 2143 3887.5 2926
CSTB 6761 9377.5 1571
CTSA 9394 10672.5 -1790
CTSB 9148 10925.5 1504
CTSC 2530 9602.5 4989
CTSD 9315 10929.5 -6421
CTSG 5165 -4374.5 1749
CTSH 6267 5854.5 -2684
CTSS 8171 7461.5 7484
CTSZ 8852 9923.5 -5150
CXCL1 5450 5556.5 -1705
CXCR1 6749 8664.5 -733
CXCR2 5774 6067.5 795
CYB5R3 8742 10554.5 -3116
CYBA 6852 9932.5 -4377
CYBB 8851 9580.5 6533
CYFIP1 9115 10172.5 -922
CYSTM1 9111 10433.5 -2440
DBNL 7743 9317.5 -7628
DDOST 6872 8730.5 -8216
DDX3X 6616 543.5 -1023
DEFA1 5874 -1339.5 3478
DEFA4 6106 -2453.5 747
DEGS1 6199 5131.5 -2612
DERA 8311 9668.5 7649
DGAT1 5306 3484.5 -6660
DIAPH1 -698 7756.5 1629
DNAJC13 8028 9733.5 11410
DNAJC3 8337 9705.5 7588
DNAJC5 8604 10179.5 -5804
DNASE1L1 8441 10982.5 475
DOCK2 7518 9883.5 1527
DOK3 9278 10983.5 339
DPP7 -4400 -6009.5 -8464
DSC1 -6375 -9614.5 1296
DSN1 -10602 -4483.5 9357
DSP -1214 -5604.5 -7224
DYNC1H1 -7552 1212.5 -825
DYNC1LI1 6891 8742.5 7681
DYNLL1 5966 3384.5 -4930
DYNLT1 4431 6908.5 8255
EEF1A1 -4906 -9481.5 -8440
EEF2 288 -5359.5 -8900
ELANE 7196 -2696.5 3029
ENPP4 -9489 -441.5 1830
EPX -4436 -5621.5 7814
ERP44 6688 6900.5 9795
FABP5 6038 7707.5 2682
FAF2 5566 7313.5 -2033
FCAR 9057 10054.5 -2519
FCER1G 8020 10876.5 3528
FCGR2A 8714 10115.5 5614
FCGR3B 4298 1686.5 1543
FCN1 9014 8029.5 -4726
FGL2 274 -3299.5 11032
FGR 8267 10927.5 360
FOLR3 7095 7239.5 -1697
FPR1 9222 10826.5 -1946
FPR2 9127 10656.5 3841
FRK 93 3642.5 8717
FRMPD3 -11095 -2558.5 -5211
FTH1 4811 6607.5 -216
FTL 8556 9946.5 -788
FUCA1 7398 6774.5 -6582
FUCA2 8068 7434.5 5924
GAA 7910 8477.5 -3651
GALNS 7078 8537.5 -1484
GCA 9332 10674.5 6420
GDI2 7230 8012.5 5667
GGH 6298 8169.5 6380
GHDC 4168 1585.5 -5168
GLA 8274 10497.5 3769
GLB1 8513 10124.5 939
GLIPR1 7689 4529.5 5338
GM2A 8853 10666.5 7237
GMFG 8249 9323.5 -5410
GNS 9153 11008.5 5372
GOLGA7 4070 1845.5 1146
GPI 6159 8370.5 -88
GPR84 9137 10432.5 1854
GRN 9120 10578.5 2841
GSDMD 1962 -399.5 -4709
GSN 8663 10386.5 -3364
GSTP1 196 1264.5 -4706
GUSB 7345 10841.5 -76
GYG1 8991 10631.5 -2416
HBB 8395 5141.5 -6980
HEBP2 8347 6958.5 -6948
HEXB 8607 8736.5 856
HGSNAT 1857 1371.5 4458
HK3 9267 10991.5 2251
HLA-A -2513 -5958.5 -8779
HLA-B 653 456.5 -760
HLA-C 1023 2077.5 -393
HLA-H -3773 -1968.5 -8067
HMGB1 -200 -3813.5 3549
HMOX2 -11427 -8836.5 -8763
HP 9357 10960.5 5265
HPSE 8297 8516.5 5242
HRNR -6976 -5778.5 -6104
HSP90AA1 1338 -1973.5 6514
HSP90AB1 -6472 -9261.5 -3472
HSPA1A 8054 8763.5 -5033
HSPA1B 6404 6981.5 -1799
HSPA6 6489 8812.5 -1079
HSPA8 -10571 -9201.5 -184
HUWE1 -7767 -794.5 -2141
HVCN1 4793 -626.5 -6157
IDH1 9386 11012.5 8168
IGF2R 7163 10134.5 -6354
ILF2 -1995 -3583.5 -4900
IMPDH1 9207 10857.5 -2395
IMPDH2 -9289 -10305.5 -8979
IQGAP1 8062 9909.5 517
IQGAP2 6198 9155.5 9462
IST1 5866 8462.5 93
ITGAL -10670 2169.5 -990
ITGAM 9293 10834.5 -6933
ITGAV 6048 7400.5 5665
ITGAX 7320 10618.5 353
ITGB2 8763 10655.5 -5669
JUP -5354 -2583.5 5658
KCMF1 7832 8676.5 -2087
KCNAB2 0 7174.5 -6958
KPNB1 2474 5655.5 8917
KRT1 4551 -4600.5 -7874
LAIR1 7194 10722.5 -4814
LAMP1 7500 9839.5 -6584
LAMP2 8661 9355.5 6377
LAMTOR1 9290 9413.5 -7781
LAMTOR2 7590 8466.5 -8684
LAMTOR3 7579 6491.5 5787
LCN2 7637 3751.5 5181
LGALS3 8482 9526.5 1346
LILRB2 7912 11010.5 4436
LILRB3 8651 10419.5 -181
LPCAT1 -7297 7064.5 -5942
LRG1 8746 10490.5 -6344
LRMP 442 4370.5 8527
LRRC7 -1966 -1449.5 724
LTA4H 9144 10326.5 2359
LTF 6095 -1826.5 3807
LYZ 7097 1124.5 1971
MAGT1 2679 6096.5 7014
MAN2B1 6759 6273.5 -4568
MANBA 7254 7837.5 8583
MAPK1 7410 10809.5 652
MAPK14 9065 10677.5 1318
MCEMP1 9397 10953.5 -7345
METTL7A 6898 7924.5 7092
MGAM 9059 10501.5 -6504
MGST1 9371 10017.5 2139
MIF -3713 -6983.5 -8503
MLEC 2300 1522.5 -5148
MME -3312 -6399.5 -2821
MMP25 8492 10344.5 -3379
MMP8 8362 7338.5 3815
MMP9 9213 10391.5 -4548
MNDA 9179 9107.5 6963
MOSPD2 8188 10366.5 11870
MPO 7257 -2892.5 2539
MS4A3 2357 -3974.5 9353
MVP 7005 8471.5 -929
NAPRT 7396 9375.5 1182
NBEAL2 7056 9854.5 -877
NCKAP1L 7406 10931.5 6276
NCSTN 8989 11024.5 4632
NDUFC2 6112 6291.5 -8021
NEU1 8934 10694.5 1859
NFAM1 8969 10543.5 -1710
NFASC 876 5710.5 9910
NFKB1 6278 2931.5 -1910
NHLRC3 1257 5591.5 12071
NIT2 -11330 -9291.5 4942
NME2 1839 36.5 -2739
NPC2 5403 5528.5 4462
NRAS 5348 6249.5 9510
OLFM4 7888 8323.5 2711
OLR1 2430 -3411.5 6280
ORM1 7960 4155.5 -6827
ORM2 -2529 581.5 -2551
ORMDL3 -9669 -6797.5 -2898
OSCAR 8993 10959.5 5512
OSTF1 7412 8868.5 -1513
P2RX1 8313 11011.5 7093
PA2G4 -3842 -4309.5 -801
PADI2 9205 9927.5 -6685
PAFAH1B2 6924 7196.5 3936
PDAP1 5921 8765.5 -8524
PDXK 8525 8724.5 -3645
PECAM1 7628 10271.5 6038
PFKL -3192 -3765.5 -6836
PGAM1 9318 10790.5 -5969
PGLYRP1 7929 6124.5 -1443
PGM1 5868 7269.5 -7430
PGM2 9253 10302.5 -4533
PGRMC1 7747 2904.5 -1355
PIGR -4587 -3578.5 -7407
PKM 9238 10434.5 -2409
PLAC8 8473 10754.5 1273
PLAU 4921 3730.5 -4348
PLAUR 8359 10069.5 -706
PLD1 9090 10848.5 7772
PLEKHO2 8015 10645.5 1425
PNP 8392 7349.5 188
PPBP 5948 3165.5 -416
PPIA -6664 -5154.5 -7862
PPIE -8462 -7253.5 -370
PRCP 8095 9229.5 802
PRDX4 -86 546.5 7813
PRDX6 8838 6597.5 -4737
PRKCD 8863 10742.5 2436
PRTN3 6728 -4998.5 -4402
PSAP 6811 9280.5 4428
PSEN1 7727 10233.5 8327
PSMA2 5370 1200.5 -1934
PSMA5 -5950 -5971.5 2553
PSMB1 3392 -1486.5 -4200
PSMB7 8402 8767.5 -8051
PSMC2 2677 6003.5 5053
PSMC3 2004 2103.5 -7327
PSMD1 7176 8773.5 6902
PSMD11 6208 7750.5 7960
PSMD12 6446 7706.5 12017
PSMD13 5911 5657.5 -4863
PSMD14 2684 3011.5 5544
PSMD2 7361 8504.5 -8125
PSMD3 4643 5031.5 -7866
PSMD6 7763 7208.5 3071
PSMD7 5937 4645.5 4394
PTAFR 9235 10003.5 -4625
PTGES2 -6562 -6678.5 -7170
PTPN6 6089 9872.5 -226
PTPRB -7471 -3496.5 -4733
PTPRC 2238 7074.5 9361
PTPRJ 7717 10192.5 -3019
PTPRN2 5144 3514.5 -4586
PTX3 5701 3223.5 9167
PYCARD 8592 10185.5 -2994
PYGB 479 -11.5 -7138
PYGL 9321 10564.5 -3485
QPCT 9230 10278.5 -1535
QSOX1 9146 10984.5 -2301
RAB10 8770 10685.5 5175
RAB14 6987 7274.5 8101
RAB18 7774 6971.5 7759
RAB24 5352 8561.5 6254
RAB27A 8372 9540.5 4675
RAB31 9196 10591.5 8501
RAB37 -11458 -2396.5 -1756
RAB3A 8119 7017.5 -7828
RAB3D 9076 10411.5 1756
RAB44 535 -700.5 4606
RAB4B 3203 8254.5 -5253
RAB5B 6707 8075.5 -5188
RAB5C 8548 9669.5 -6428
RAB6A 8096 9805.5 6358
RAB7A 8633 10048.5 -2737
RAB9B -6256 -5343.5 -2161
RAC1 8578 10538.5 7795
RAP1A 7212 8328.5 9770
RAP1B 3302 8354.5 8566
RAP2B -685 5070.5 -1174
RAP2C 4629 7790.5 7780
RETN 9086 10658.5 2678
RHOA 8091 9816.5 4832
RHOF -11929 -8746.5 -5144
RHOG 8411 10285.5 -3833
RNASE2 9398 10847.5 4593
RNASE3 7629 4404.5 -298
RNASET2 5873 8158.5 619
ROCK1 7336 9040.5 11587
S100A11 8858 10536.5 2875
S100A12 9404 10844.5 -6625
S100A8 9399 10822.5 -2187
S100A9 9401 10256.5 -4105
S100P 8419 9809.5 -5192
SCAMP1 1820 -4501.5 9228
SDCBP 9210 9789.5 3196
SELL 8873 9751.5 3158
SERPINA1 9026 10996.5 8618
SERPINB1 9306 10852.5 4958
SERPINB10 8836 7335.5 7372
SERPINB6 5719 7004.5 -5171
SIGLEC14 5092 4807.5 -1645
SIGLEC5 8252 8439.5 -2647
SIGLEC9 9251 10969.5 -1586
SIRPA 9389 10999.5 -3356
SIRPB1 7687 7657.5 -5053
SLC11A1 9002 11032.5 5244
SLC15A4 3829 10313.5 3611
SLC27A2 -3784 -4006.5 11172
SLC2A3 8994 10409.5 -2862
SLC2A5 2095 -3455.5 3441
SLC44A2 2712 5250.5 -6452
SLCO4C1 3415 8526.5 4621
SLPI 5358 1312.5 7055
SNAP23 8444 8499.5 7122
SNAP29 6328 9432.5 -6689
SPTAN1 -11087 -9600.5 -6808
SRP14 6321 6875.5 408
STBD1 5674 6864.5 -2462
STING1 4789 -684.5 -5695
STK10 -3696 8590.5 -4884
STK11IP 3600 7638.5 -7526
STOM 6863 8701.5 3046
SURF4 7042 8599.5 -6091
SVIP 2109 -607.5 4608
SYNGR1 -4551 957.5 -513
TARM1 5323 7135.5 7868
TBC1D10C -11211 -8502.5 -8904
TCIRG1 7159 10526.5 -3834
TCN1 6193 1168.5 5870
TICAM2 6157 5483.5 10526
TIMP2 9328 10875.5 -725
TLR2 8919 10240.5 8626
TMBIM1 8295 9890.5 -6071
TMC6 -10019 -7649.5 -5254
TMEM179B 492 -469.5 527
TMEM30A 7875 7933.5 8159
TMEM63A -8148 -9173.5 -112
TNFAIP6 8823 10420.5 3097
TNFRSF1B 5837 9955.5 1584
TOLLIP 8529 9384.5 -7143
TOM1 8983 10418.5 -4276
TRAPPC1 7768 9277.5 -5178
TRPM2 8999 10664.5 -2988
TSPAN14 6906 10425.5 -507
TUBB -6834 -1434.5 -3098
TUBB4B 7234 7628.5 -3224
TXNDC5 543 -4017.5 5513
TYROBP 7476 9315.5 -3948
UBR4 -2062 5226.5 1313
UNC13D 7574 10777.5 -4098
VAMP8 5224 1699.5 -8809
VAPA 8923 9708.5 4027
VAT1 9169 10746.5 -7507
VCL 7273 7218.5 -1287
VCP 6855 8134.5 -6244
VNN1 9001 10799.5 6437
VPS35L 6047 9381.5 5549
XRCC5 5388 4665.5 2238
XRCC6 -4332 -5938.5 -4506
YPEL5 6631 6888.5 6832



Trafficking of GluR2-containing AMPA receptors

metric value
setSize 12
pMANOVA 0.000481
p.adjustMANOVA 0.00167
s.dist 0.78
s.t0_v_pod 0.471
s.pod_crp 0.49
s.t0_crp -0.383
p.t0_v_pod 0.0047
p.pod_crp 0.00329
p.t0_crp 0.0215




Gene pod_crp t0_v_pod
NSF 9834.5 8672
AP2M1 9148.5 8534
AP2A1 10946.5 6537
AP2S1 8636.5 7958
AP2A2 9259.5 7253
TSPAN7 8689.5 7286
PRKCB 9016.5 6954
PICK1 7153.5 3684

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AP2A1 6537 10946.5 315
AP2A2 7253 9259.5 -7222
AP2B1 -2677 2779.5 -3730
AP2M1 8534 9148.5 -8293
AP2S1 7958 8636.5 -5676
GRIA4 -101 4344.5 6868
GRIP1 -10180 -9660.5 441
NSF 8672 9834.5 -858
PICK1 3684 7153.5 -4744
PRKCA 1153 -3131.5 -3930
PRKCB 6954 9016.5 -815
TSPAN7 7286 8689.5 -2349



Detoxification of Reactive Oxygen Species

metric value
setSize 32
pMANOVA 2.21e-08
p.adjustMANOVA 2.1e-07
s.dist 0.779
s.t0_v_pod 0.56
s.pod_crp 0.493
s.t0_crp -0.224
p.t0_v_pod 4.23e-08
p.pod_crp 1.37e-06
p.t0_crp 0.0283




Gene t0_v_pod pod_crp
GSR 9101 10803.5
PRDX3 9221 10382.5
NCF2 9055 10493.5
NCF4 9208 10116.5
CAT 8987 10088.5
CYBB 8851 9580.5
ERO1A 8709 9721.5
P4HB 8321 10108.5
TXNRD1 8174 9744.5
PRDX5 8475 9245.5
TXN 8284 9290.5
GPX1 9223 7552.5
CYBA 6852 9932.5
PRDX6 8838 6597.5
TXNRD2 7445 6382.5
PRDX1 7001 5599.5
NCF1 7324 5317.5
ATOX1 4396 7505.5
SOD2 4415 6299.5
TXN2 4677 3878.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ATOX1 4396 7505.5 -5362
ATP7A 642 4391.5 -1902
CAT 8987 10088.5 3197
CCS 1364 -2654.5 -8496
CYBA 6852 9932.5 -4377
CYBB 8851 9580.5 6533
CYCS -1265 -1903.5 6109
ERO1A 8709 9721.5 11220
GPX1 9223 7552.5 -7971
GPX2 -3454 3047.5 8107
GPX3 849 9305.5 -162
GPX7 -8749 -8144.5 -7830
GSR 9101 10803.5 -2790
GSTP1 196 1264.5 -4706
NCF1 7324 5317.5 -1274
NCF2 9055 10493.5 3160
NCF4 9208 10116.5 -6822
NOX4 1107 5838.5 10223
NOX5 1269 6752.5 11793
NUDT2 3063 2227.5 -3127
P4HB 8321 10108.5 -6293
PRDX1 7001 5599.5 4146
PRDX2 3435 -2801.5 -5483
PRDX3 9221 10382.5 6191
PRDX5 8475 9245.5 -8499
PRDX6 8838 6597.5 -4737
SOD1 -4767 -6302.5 -6043
SOD2 4415 6299.5 2890
TXN 8284 9290.5 761
TXN2 4677 3878.5 -8027
TXNRD1 8174 9744.5 -1886
TXNRD2 7445 6382.5 -3998



RHO GTPases Activate NADPH Oxidases

metric value
setSize 21
pMANOVA 1.22e-05
p.adjustMANOVA 6.47e-05
s.dist 0.775
s.t0_v_pod 0.557
s.pod_crp 0.481
s.t0_crp -0.243
p.t0_v_pod 9.74e-06
p.pod_crp 0.000136
p.t0_crp 0.0544




Gene t0_v_pod pod_crp
S100A8 9399 10822.5
MAPK14 9065 10677.5
S100A9 9401 10256.5
PRKCD 8863 10742.5
NCF2 9055 10493.5
NCF4 9208 10116.5
RAC1 8578 10538.5
CYBB 8851 9580.5
MAPK1 7410 10809.5
MAPK3 8928 8957.5
CYBA 6852 9932.5
PRKCB 6954 9016.5
RAC2 5179 7665.5
NCF1 7324 5317.5
PIK3C3 1613 587.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CYBA 6852 9932.5 -4377
CYBB 8851 9580.5 6533
MAPK1 7410 10809.5 652
MAPK11 3916 -2134.5 1542
MAPK14 9065 10677.5 1318
MAPK3 8928 8957.5 -9052
NCF1 7324 5317.5 -1274
NCF2 9055 10493.5 3160
NCF4 9208 10116.5 -6822
NOXA1 -5345 -4097.5 129
PIK3C3 1613 587.5 10521
PIK3R4 -3914 -3607.5 1781
PIN1 -3181 -137.5 -8886
PRKCA 1153 -3131.5 -3930
PRKCB 6954 9016.5 -815
PRKCD 8863 10742.5 2436
PRKCZ -11155 -7229.5 -7936
RAC1 8578 10538.5 7795
RAC2 5179 7665.5 -7355
S100A8 9399 10822.5 -2187
S100A9 9401 10256.5 -4105



COPI-independent Golgi-to-ER retrograde traffic

metric value
setSize 33
pMANOVA 2.83e-07
p.adjustMANOVA 2.33e-06
s.dist 0.764
s.t0_v_pod 0.561
s.pod_crp 0.518
s.t0_crp -0.0341
p.t0_v_pod 2.44e-08
p.pod_crp 2.55e-07
p.t0_crp 0.735




Gene t0_v_pod pod_crp
DCTN2 9007 10388.5
GALNT2 8751 10667.5
PLA2G4A 9079 9775.5
DCTN4 8255 10407.5
BICD2 8644 9454.5
RAB6A 8096 9805.5
CAPZA1 8042 9664.5
CAPZB 7935 9704.5
CAPZA2 8388 9068.5
ACTR1A 6985 9935.5
DYNC1I2 7516 8535.5
DYNC1LI1 6891 8742.5
ACTR10 7539 7788.5
DCTN6 7275 8025.5
RAB18 7774 6971.5
PAFAH1B2 6924 7196.5
GALNT1 6427 7650.5
DCTN1 5085 9247.5
PAFAH1B1 5468 8200.5
DCTN3 5996 7355.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ACTR10 7539 7788.5 5184
ACTR1A 6985 9935.5 -6330
AGPAT3 4578 8114.5 9500
BICD1 -7069 -3831.5 1700
BICD2 8644 9454.5 -7404
CAPZA1 8042 9664.5 8423
CAPZA2 8388 9068.5 8762
CAPZB 7935 9704.5 -3411
DCTN1 5085 9247.5 -6425
DCTN2 9007 10388.5 -8226
DCTN3 5996 7355.5 -7167
DCTN4 8255 10407.5 9163
DCTN5 -4011 -438.5 -3548
DCTN6 7275 8025.5 7730
DYNC1H1 -7552 1212.5 -825
DYNC1I1 4172 2691.5 5071
DYNC1I2 7516 8535.5 4221
DYNC1LI1 6891 8742.5 7681
DYNC1LI2 4212 6631.5 6891
DYNLL1 5966 3384.5 -4930
DYNLL2 -3916 -4146.5 -7052
GALNT1 6427 7650.5 6725
GALNT2 8751 10667.5 -5179
PAFAH1B1 5468 8200.5 -260
PAFAH1B2 6924 7196.5 3936
PAFAH1B3 4330 -3613.5 -8869
PLA2G4A 9079 9775.5 2589
PLA2G6 -11661 -8016.5 -6707
RAB18 7774 6971.5 7759
RAB3GAP1 5726 4565.5 11207
RAB3GAP2 4435 7134.5 10810
RAB6A 8096 9805.5 6358
RAB6B 6063 1810.5 -6714



Translation initiation complex formation

metric value
setSize 58
pMANOVA 2.52e-28
p.adjustMANOVA 8.56e-27
s.dist 0.758
s.t0_v_pod -0.0222
s.pod_crp -0.472
s.t0_crp -0.593
p.t0_v_pod 0.77
p.pod_crp 5.1e-10
p.t0_crp 5.29e-15




Gene t0_crp pod_crp
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPS27 -8998 -9300.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPS15A -8955 -8640.5
RPS16 -8966 -8515.5
RPS10 -9032 -8385.5
RPS20 -7998 -9180.5
RPS7 -8575 -8531.5
RPS17 -9077 -8041.5
RPS21 -9038 -7972.5
RPS11 -9014 -7986.5
RPS18 -8554 -8380.5
RPS28 -8958 -7992.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
FAU -398 -3107.5 -8957
PABPC1 5341 171.5 4499
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637



rRNA processing

metric value
setSize 217
pMANOVA 2.99e-60
p.adjustMANOVA 2.71e-58
s.dist 0.757
s.t0_v_pod -0.291
s.pod_crp -0.529
s.t0_crp -0.456
p.t0_v_pod 1.46e-13
p.pod_crp 2.54e-41
p.t0_crp 4.11e-31




Gene pod_crp t0_crp
FBL -10014.5 -9029
RPL3 -9970.5 -8984
RPL14 -9780.5 -8971
RPS27A -9698.5 -9022
RPS25 -9664.5 -8793
RPLP2 -9244.5 -9085
RPS27 -9300.5 -8998
RPL5 -9893.5 -8450
RPS6 -9602.5 -8694
RPS2 -9114.5 -9084
RPS3 -9149.5 -9021
RPL32 -9346.5 -8747
RPS12 -9016.5 -9041
RPS5 -9110.5 -8931
RPL7 -9317.5 -8731
RPS29 -8819.5 -9075
RPS23 -9063.5 -8770
WDR46 -9002.5 -8805
RPL23A -10055.5 -7855
RPL30 -8740.5 -8940

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BMS1 -11259 -9837.5 -3049
BOP1 -5067 -6215.5 -8182
BYSL -4260 -5812.5 -8348
C1D 3589 2173.5 10355
CSNK1D 2397 6982.5 -7878
CSNK1E -9907 -7297.5 -6962
DCAF13 -5439 -6161.5 -1571
DDX21 3105 1476.5 10298
DDX47 -10803 -9741.5 3472
DDX49 4883 4133.5 -7546
DDX52 497 2715.5 12255
DHX37 -8019 -5530.5 -4867
DIMT1 -7807 -9429.5 8033
DIS3 -4223 -3621.5 11499
DKC1 -11128 -10321.5 -4947
EBNA1BP2 -4046 -6622.5 -4968
ELAC2 -11462 -5076.5 -5744
EMG1 -9832 -8867.5 2684
ERI1 5530 7049.5 11839
EXOSC1 -964 324.5 4024
EXOSC10 -11064 -7501.5 4924
EXOSC2 -10523 -10042.5 -6551
EXOSC3 484 -344.5 1768
EXOSC4 7666 9691.5 -6570
EXOSC5 -4274 -8642.5 -7815
EXOSC6 -9683 -5334.5 -73
EXOSC7 -10418 -8248.5 -8749
EXOSC8 -10978 -9706.5 2811
EXOSC9 -10090 -8249.5 9499
FAU -398 -3107.5 -8957
FBL -9778 -10014.5 -9029
FCF1 4510 2971.5 3971
FTSJ3 -3832 131.5 174
GAR1 -6778 -6732.5 -2718
GNL3 -8083 -10106.5 1676
HEATR1 -9924 -8126.5 2205
HSD17B10 4242 4980.5 -6146
IMP3 -8978 -7554.5 -7770
IMP4 -10341 -8253.5 -8102
ISG20L2 3807 4583.5 4556
KRR1 -8302 -8139.5 6121
LAS1L -11837 -9902.5 -5801
LTV1 -4115 -7205.5 2005
MPHOSPH10 -7610 -8478.5 11201
MPHOSPH6 2229 -670.5 3568
MRM1 -9229 -9587.5 -7574
MRM2 1488 -3281.5 -2232
MRM3 -7389 -5047.5 -4304
MT-ATP6 -2061 -445.5 -6676
MT-ATP8 -2884 2539.5 -8683
MT-CO1 670 88.5 166
MT-CO2 35 -1075.5 -4508
MT-CO3 47 -3568.5 -7343
MT-CYB -2261 -1376.5 -1347
MT-ND1 -3583 -3838.5 -3250
MT-ND2 -6432 -4074.5 -982
MT-ND3 -3577 -3537.5 -6017
MT-ND4 822 3783.5 6874
MT-ND4L -2023 2054.5 -5257
MT-ND5 -2170 -545.5 -782
MT-RNR1 -288 -1816.5 145
MT-RNR2 2176 2604.5 658
MT-TF -2662 2785.5 -4188
MT-TL1 -2804 4440.5 1033
MT-TV -3627 2283.5 -5615
MTERF4 -10198 -10184.5 -6728
MTREX -2587 -3781.5 5798
NAT10 -11508 -10101.5 -4796
NCL -9079 -8956.5 -5195
NHP2 -3395 -6371.5 -8264
NIP7 -5758 -6840.5 1638
NOB1 -10031 -8712.5 -7293
NOC4L -5327 1541.5 2328
NOL11 -9893 -10169.5 3608
NOL12 4909 2843.5 -5893
NOL6 -10505 -8619.5 -4953
NOL9 -9870 -9196.5 7645
NOP10 8331 9945.5 -7324
NOP14 -10583 -9836.5 -4349
NOP2 -9186 -9188.5 -7692
NOP56 -11150 -9853.5 -4229
NOP58 -9707 -10146.5 7541
NSUN4 -4665 2428.5 8663
PDCD11 -11196 -6754.5 -5153
PELP1 -10500 -8949.5 -3822
PES1 -1986 -5090.5 -8225
PNO1 -6716 -6607.5 9516
PRORP 3385 -1224.5 3002
PWP2 -979 -537.5 -2293
RBM28 -11328 -6684.5 -67
RCL1 -827 -7181.5 -4488
RIOK1 -3673 -5171.5 1250
RIOK2 938 -7112.5 9609
RIOK3 8613 7808.5 11605
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPP14 3083 342.5 5701
RPP21 -5058 -5368.5 -8141
RPP25 -8062 -8272.5 -4531
RPP30 -7922 -8271.5 6663
RPP38 -6620 -8456.5 3602
RPP40 -4570 -10208.5 3149
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
RRP1 -3035 -2655.5 4041
RRP36 -1483 2381.5 -3338
RRP7A -2752 -3730.5 -4140
RRP9 -9725 -8788.5 -8383
SENP3 3004 -1009.5 -3512
SNORD3A -2249 9350.5 9071
SNU13 -6683 -8010.5 -8297
TBL3 -3372 -617.5 -6850
TEX10 -9534 -8892.5 10010
TFB1M -11033 -7250.5 4071
THUMPD1 -9539 -9971.5 7205
TRMT10C -4349 -7731.5 6328
TRMT112 581 -2621.5 -9010
TSR1 -9314 -9987.5 2103
TSR3 3871 3345.5 -8960
UBA52 1062 -2813.5 -8649
UTP11 4659 2445.5 5799
UTP14A -1765 -1115.5 2230
UTP14C -1614 1103.5 7508
UTP15 -10212 -9487.5 9817
UTP18 5105 3913.5 584
UTP20 -10098 -8186.5 7274
UTP3 -2864 -4281.5 -5024
UTP4 -11042 -9930.5 -146
UTP6 -4379 -8202.5 5491
WDR12 5227 1380.5 4923
WDR18 -2350 -3255.5 -5475
WDR3 -6376 -7406.5 -927
WDR36 -3725 -5865.5 4916
WDR43 -7301 -9654.5 -1341
WDR46 -10704 -9002.5 -8805
WDR75 -9487 -10092.5 7131
XRN2 9257 10133.5 538



Golgi Cisternae Pericentriolar Stack Reorganization

metric value
setSize 14
pMANOVA 0.00435
p.adjustMANOVA 0.0111
s.dist 0.754
s.t0_v_pod 0.548
s.pod_crp 0.509
s.t0_crp 0.098
p.t0_v_pod 0.000383
p.pod_crp 0.000982
p.t0_crp 0.526




Gene t0_v_pod pod_crp
RAB1A 8925 9888.5
RAB2A 8461 9908.5
RAB1B 8277 9851.5
MAPK1 7410 10809.5
MAPK3 8928 8957.5
GOLGA2 6130 9434.5
GORASP1 6577 8145.5
CCNB2 3798 7156.5
USO1 4153 3797.5
BLZF1 3297 4345.5
PLK1 3040 4262.5
CCNB1 455 1058.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BLZF1 3297 4345.5 12024
CCNB1 455 1058.5 3518
CCNB2 3798 7156.5 2683
CDK1 1469 -827.5 9615
GOLGA2 6130 9434.5 616
GORASP1 6577 8145.5 2506
GORASP2 -6848 -5816.5 -2247
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
PLK1 3040 4262.5 1185
RAB1A 8925 9888.5 5625
RAB1B 8277 9851.5 -7972
RAB2A 8461 9908.5 7252
USO1 4153 3797.5 10590



Ribosomal scanning and start codon recognition

metric value
setSize 58
pMANOVA 1.57e-27
p.adjustMANOVA 5.22e-26
s.dist 0.754
s.t0_v_pod -0.0273
s.pod_crp -0.467
s.t0_crp -0.591
p.t0_v_pod 0.719
p.pod_crp 7.33e-10
p.t0_crp 6.72e-15




Gene t0_crp pod_crp
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPS27 -8998 -9300.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPS15A -8955 -8640.5
RPS16 -8966 -8515.5
RPS10 -9032 -8385.5
RPS20 -7998 -9180.5
RPS7 -8575 -8531.5
RPS17 -9077 -8041.5
RPS21 -9038 -7972.5
RPS11 -9014 -7986.5
RPS18 -8554 -8380.5
RPS28 -8958 -7992.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
EIF5 2190 2858.5 5909
FAU -398 -3107.5 -8957
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637



DNA strand elongation

metric value
setSize 32
pMANOVA 1.84e-06
p.adjustMANOVA 1.25e-05
s.dist 0.753
s.t0_v_pod -0.527
s.pod_crp -0.526
s.t0_crp -0.114
p.t0_v_pod 2.47e-07
p.pod_crp 2.55e-07
p.t0_crp 0.266




Gene t0_v_pod pod_crp
MCM3 -11802 -9993.5
POLA1 -11760 -9972.5
RPA1 -11603 -9864.5
MCM7 -11645 -9709.5
LIG1 -10136 -9954.5
POLD2 -9600 -10256.5
RFC3 -10179 -9512.5
RFC4 -10175 -9337.5
PRIM1 -9846 -9354.5
POLA2 -11286 -7969.5
RFC5 -11399 -7690.5
GINS4 -10060 -7766.5
RPA3 -8697 -8931.5
MCM6 -9616 -7523.5
MCM8 -10645 -6256.5
FEN1 -10402 -5934.5
MCM4 -8518 -6453.5
GINS3 -10188 -5352.5
MCM2 -7064 -6228.5
PCNA -5838 -6623.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CDC45 -2615 -3919.5 2286
DNA2 -2807 -5876.5 10746
FEN1 -10402 -5934.5 -5164
GINS1 -4295 2947.5 7784
GINS2 -4688 -2051.5 3425
GINS3 -10188 -5352.5 1452
GINS4 -10060 -7766.5 4198
LIG1 -10136 -9954.5 -5819
MCM2 -7064 -6228.5 -4440
MCM3 -11802 -9993.5 -4964
MCM4 -8518 -6453.5 3033
MCM5 -7172 -2261.5 -6004
MCM6 -9616 -7523.5 1545
MCM7 -11645 -9709.5 -5017
MCM8 -10645 -6256.5 3870
PCNA -5838 -6623.5 1994
POLA1 -11760 -9972.5 -1080
POLA2 -11286 -7969.5 7922
POLD1 132 -4342.5 -8168
POLD2 -9600 -10256.5 -8327
POLD3 8570 10512.5 9422
POLD4 6339 8280.5 -7459
PRIM1 -9846 -9354.5 6363
PRIM2 -5431 -6436.5 47
RFC1 -7269 -3251.5 9849
RFC2 4982 6761.5 -4032
RFC3 -10179 -9512.5 875
RFC4 -10175 -9337.5 1350
RFC5 -11399 -7690.5 3523
RPA1 -11603 -9864.5 -6611
RPA2 -6185 -4258.5 657
RPA3 -8697 -8931.5 -1025



Insulin receptor recycling

metric value
setSize 21
pMANOVA 3.59e-05
p.adjustMANOVA 0.00017
s.dist 0.753
s.t0_v_pod 0.568
s.pod_crp 0.463
s.t0_crp -0.173
p.t0_v_pod 6.68e-06
p.pod_crp 0.000237
p.t0_crp 0.17




Gene t0_v_pod pod_crp
ATP6V0A1 9323 10787.5
ATP6V0D1 9142 10689.5
ATP6V0C 8963 10683.5
ATP6V1A 9145 9804.5
ATP6V1D 8968 9974.5
ATP6AP1 7914 10947.5
ATP6V1B2 8856 9625.5
ATP6V1C1 8490 9611.5
ATP6V0B 8559 9424.5
INSR 7980 9655.5
ATP6V0E1 8523 8936.5
TCIRG1 7159 10526.5
ATP6V1H 7996 8646.5
ATP6V1E1 7984 8634.5
ATP6V1F 5870 4524.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ATP6AP1 7914 10947.5 -4539
ATP6V0A1 9323 10787.5 -2130
ATP6V0A2 -11832 -6666.5 10381
ATP6V0B 8559 9424.5 -6577
ATP6V0C 8963 10683.5 22
ATP6V0D1 9142 10689.5 -3011
ATP6V0E1 8523 8936.5 -5226
ATP6V0E2 -11124 -9666.5 -2466
ATP6V1A 9145 9804.5 5720
ATP6V1B2 8856 9625.5 3453
ATP6V1C1 8490 9611.5 6525
ATP6V1C2 -2174 -3183.5 2487
ATP6V1D 8968 9974.5 1966
ATP6V1E1 7984 8634.5 2761
ATP6V1E2 5702 -655.5 -4761
ATP6V1F 5870 4524.5 -7964
ATP6V1G1 3950 -1572.5 -2198
ATP6V1G2 -8958 -9490.5 222
ATP6V1H 7996 8646.5 -2171
INSR 7980 9655.5 6098
TCIRG1 7159 10526.5 -3834



Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

metric value
setSize 59
pMANOVA 2.33e-28
p.adjustMANOVA 8.12e-27
s.dist 0.748
s.t0_v_pod -0.0102
s.pod_crp -0.457
s.t0_crp -0.592
p.t0_v_pod 0.893
p.pod_crp 1.24e-09
p.t0_crp 3.56e-15




Gene t0_crp pod_crp
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPS27 -8998 -9300.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPS15A -8955 -8640.5
RPS16 -8966 -8515.5
RPS10 -9032 -8385.5
RPS20 -7998 -9180.5
RPS7 -8575 -8531.5
RPS17 -9077 -8041.5
RPS21 -9038 -7972.5
RPS11 -9014 -7986.5
RPS18 -8554 -8380.5
RPS28 -8958 -7992.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EIF1AX 1091 -6815.5 2403
EIF2S1 4296 225.5 5944
EIF2S2 6116 4417.5 8603
EIF2S3 6714 4847.5 5186
EIF3A 2123 813.5 3711
EIF3B -7892 -9162.5 -7606
EIF3C 273 -3326.5 -8725
EIF3D 2623 -4107.5 -7756
EIF3E 1920 -7923.5 1373
EIF3F 916 -4516.5 -8977
EIF3G 872 -2077.5 -8866
EIF3H 4751 -4770.5 -6012
EIF3I 4713 -595.5 -8137
EIF3J 1925 -3864.5 8912
EIF3K 1508 -1060.5 -6888
EIF3L 2574 -6924.5 -8853
EIF3M 4585 -4171.5 5332
EIF4A1 7439 6859.5 -764
EIF4A2 -10567 -9947.5 3086
EIF4B 1223 -6935.5 -7588
EIF4E 4835 3445.5 8972
EIF4EBP1 6039 4528.5 -3892
EIF4G1 7959 10173.5 -4453
EIF4H 7671 8288.5 -8479
FAU -398 -3107.5 -8957
PABPC1 5341 171.5 4499
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637



ROS and RNS production in phagocytes

metric value
setSize 31
pMANOVA 4.36e-08
p.adjustMANOVA 4e-07
s.dist 0.745
s.t0_v_pod 0.598
s.pod_crp 0.416
s.t0_crp -0.156
p.t0_v_pod 8.18e-09
p.pod_crp 6.21e-05
p.t0_crp 0.133




Gene t0_v_pod pod_crp
ATP6V0A1 9323 10787.5
SLC11A1 9002 11032.5
ATP6V0D1 9142 10689.5
ATP6V0C 8963 10683.5
NCF2 9055 10493.5
NCF4 9208 10116.5
ATP6V1A 9145 9804.5
ATP6V1D 8968 9974.5
ATP6V1B2 8856 9625.5
CYBB 8851 9580.5
ATP6V1C1 8490 9611.5
ATP6V0B 8559 9424.5
ATP6V0E1 8523 8936.5
TCIRG1 7159 10526.5
ATP6V1H 7996 8646.5
ATP6V1E1 7984 8634.5
CYBA 6852 9932.5
RAC2 5179 7665.5
NCF1 7324 5317.5
ATP6V1F 5870 4524.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ATP6V0A1 9323 10787.5 -2130
ATP6V0A2 -11832 -6666.5 10381
ATP6V0B 8559 9424.5 -6577
ATP6V0C 8963 10683.5 22
ATP6V0D1 9142 10689.5 -3011
ATP6V0E1 8523 8936.5 -5226
ATP6V0E2 -11124 -9666.5 -2466
ATP6V1A 9145 9804.5 5720
ATP6V1B2 8856 9625.5 3453
ATP6V1C1 8490 9611.5 6525
ATP6V1C2 -2174 -3183.5 2487
ATP6V1D 8968 9974.5 1966
ATP6V1E1 7984 8634.5 2761
ATP6V1E2 5702 -655.5 -4761
ATP6V1F 5870 4524.5 -7964
ATP6V1G1 3950 -1572.5 -2198
ATP6V1G2 -8958 -9490.5 222
ATP6V1H 7996 8646.5 -2171
CYBA 6852 9932.5 -4377
CYBB 8851 9580.5 6533
HVCN1 4793 -626.5 -6157
LPO 6485 3150.5 8865
MPO 7257 -2892.5 2539
NCF1 7324 5317.5 -1274
NCF2 9055 10493.5 3160
NCF4 9208 10116.5 -6822
NOS1 1390 2355.5 9281
NOS3 -1690 -8415.5 -4978
RAC2 5179 7665.5 -7355
SLC11A1 9002 11032.5 5244
TCIRG1 7159 10526.5 -3834



Josephin domain DUBs

metric value
setSize 10
pMANOVA 0.00192
p.adjustMANOVA 0.00548
s.dist 0.744
s.t0_v_pod 0.469
s.pod_crp 0.296
s.t0_crp -0.496
p.t0_v_pod 0.0102
p.pod_crp 0.105
p.t0_crp 0.00656




Gene t0_crp t0_v_pod
JOSD2 -7708 7904
UBB -6574 6643
VCP -6244 6855
RAD23A -4124 6508
RAD23B -1631 8780
UBA52 -8649 1062
JOSD1 -3840 289

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ATXN3 1610 1378.5 9762
JOSD1 289 5646.5 -3840
JOSD2 7904 9703.5 -7708
RAD23A 6508 4280.5 -4124
RAD23B 8780 10030.5 -1631
RPS27A -6658 -9698.5 -9022
UBA52 1062 -2813.5 -8649
UBB 6643 1475.5 -6574
UBC 4378 6962.5 946
VCP 6855 8134.5 -6244



Nucleobase biosynthesis

metric value
setSize 13
pMANOVA 0.00181
p.adjustMANOVA 0.00521
s.dist 0.738
s.t0_v_pod -0.347
s.pod_crp -0.565
s.t0_crp -0.325
p.t0_v_pod 0.0301
p.pod_crp 0.000422
p.t0_crp 0.0426




Gene pod_crp t0_v_pod
ATIC -10258.5 -10747
PPAT -10227.5 -10553
UMPS -10125.5 -10086
PFAS -9847.5 -10327
IMPDH2 -10305.5 -9289
CAD -9584.5 -8959
PAICS -9688.5 -5001
DHODH -6229.5 -5410
GMPS -4566.5 -5292
LHPP -3912.5 -2

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ADSL 5089 -4355.5 -4691
ATIC -10747 -10258.5 -168
CAD -8959 -9584.5 -3654
DHODH -5410 -6229.5 -3077
GART -3504 4347.5 9520
GMPS -5292 -4566.5 2923
IMPDH1 9207 10857.5 -2395
IMPDH2 -9289 -10305.5 -8979
LHPP -2 -3912.5 -4485
PAICS -5001 -9688.5 3103
PFAS -10327 -9847.5 -8295
PPAT -10553 -10227.5 323
UMPS -10086 -10125.5 -4493



Signaling by Leptin

metric value
setSize 10
pMANOVA 0.00746
p.adjustMANOVA 0.0175
s.dist 0.735
s.t0_v_pod 0.564
s.pod_crp 0.4
s.t0_crp -0.25
p.t0_v_pod 0.002
p.pod_crp 0.0286
p.t0_crp 0.172




Gene t0_v_pod pod_crp
SOCS3 9365 10573.5
IRS2 8194 9803.5
STAT3 8029 9517.5
STAT5A 6883 7967.5
STAT5B 6910 7703.5
PTPN11 5322 7012.5
LEPR 6499 3858.5
JAK2 2582 3413.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
IRS1 1792 -6742.5 -6812
IRS2 8194 9803.5 -1722
JAK2 2582 3413.5 12239
LEPR 6499 3858.5 -2032
PTPN11 5322 7012.5 2127
SH2B1 -8058 -6907.5 -3754
SOCS3 9365 10573.5 -7796
STAT3 8029 9517.5 5769
STAT5A 6883 7967.5 -1407
STAT5B 6910 7703.5 -7334



Pentose phosphate pathway

metric value
setSize 13
pMANOVA 0.000932
p.adjustMANOVA 0.00293
s.dist 0.734
s.t0_v_pod 0.487
s.pod_crp 0.398
s.t0_crp -0.38
p.t0_v_pod 0.00239
p.pod_crp 0.013
p.t0_crp 0.0178




Gene t0_v_pod pod_crp
PGD 9369 10900.5
TALDO1 9344 10249.5
PGM2 9253 10302.5
G6PD 8895 10675.5
TKT 9225 9947.5
DERA 8311 9668.5
PGLS 6074 5761.5
RPE 2643 6753.5

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t0_v_pod pod_crp t0_crp
DERA 8311 9668.5 7649
G6PD 8895 10675.5 -6334
PGD 9369 10900.5 -3561
PGLS 6074 5761.5 -8237
PGM2 9253 10302.5 -4533
PRPS1 -11630 -9945.5 -6691
PRPS2 3563 -645.5 9586
RBKS -3026 608.5 -6371
RPE 2643 6753.5 3674
RPIA 1444 -4027.5 -7220
SHPK -2518 -457.5 -2412
TALDO1 9344 10249.5 -1975
TKT 9225 9947.5 -5543



Activation of the pre-replicative complex

metric value
setSize 32
pMANOVA 1.7e-06
p.adjustMANOVA 1.17e-05
s.dist 0.731
s.t0_v_pod -0.488
s.pod_crp -0.544
s.t0_crp -0.025
p.t0_v_pod 1.77e-06
p.pod_crp 1.02e-07
p.t0_crp 0.806




Gene pod_crp t0_v_pod
MCM3 -9993.5 -11802
POLA1 -9972.5 -11760
RPA1 -9864.5 -11603
MCM7 -9709.5 -11645
POLE3 -9037.5 -11290
PRIM1 -9354.5 -9846
DBF4 -8524.5 -10711
POLA2 -7969.5 -11286
ORC3 -8215.5 -10465
ORC2 -8686.5 -9552
ORC5 -8750.5 -9145
RPA3 -8931.5 -8697
MCM6 -7523.5 -9616
POLE2 -7226.5 -9781
MCM8 -6256.5 -10645
MCM4 -6453.5 -8518
MCM2 -6228.5 -7064
POLE -5308.5 -7316
CDC7 -4931.5 -7625
PRIM2 -6436.5 -5431

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CDC45 -2615 -3919.5 2286
CDC6 2384 -224.5 1492
CDC7 -7625 -4931.5 -893
CDK2 -4854 -4093.5 -3792
CDT1 -193 -409.5 -4001
DBF4 -10711 -8524.5 8765
GMNN 1426 2460.5 4759
MCM10 774 -3799.5 4550
MCM2 -7064 -6228.5 -4440
MCM3 -11802 -9993.5 -4964
MCM4 -8518 -6453.5 3033
MCM5 -7172 -2261.5 -6004
MCM6 -9616 -7523.5 1545
MCM7 -11645 -9709.5 -5017
MCM8 -10645 -6256.5 3870
ORC1 -2411 -628.5 2320
ORC2 -9552 -8686.5 3265
ORC3 -10465 -8215.5 8995
ORC4 -2004 -5862.5 8018
ORC5 -9145 -8750.5 5639
ORC6 1495 7343.5 8677
POLA1 -11760 -9972.5 -1080
POLA2 -11286 -7969.5 7922
POLE -7316 -5308.5 2249
POLE2 -9781 -7226.5 10374
POLE3 -11290 -9037.5 -7990
POLE4 5544 535.5 -6493
PRIM1 -9846 -9354.5 6363
PRIM2 -5431 -6436.5 47
RPA1 -11603 -9864.5 -6611
RPA2 -6185 -4258.5 657
RPA3 -8697 -8931.5 -1025



Formation of ATP by chemiosmotic coupling

metric value
setSize 18
pMANOVA 2.53e-06
p.adjustMANOVA 1.62e-05
s.dist 0.73
s.t0_v_pod 0.427
s.pod_crp 0.196
s.t0_crp -0.558
p.t0_v_pod 0.00171
p.pod_crp 0.15
p.t0_crp 4.1e-05




Gene t0_crp t0_v_pod
ATP5MF -8533 6524
ATP5MG -8883 5540
ATP5PB -6217 7550
ATP5F1A -6834 6445
ATP5F1E -6758 6172
ATP5MC3 -6641 5930
ATP5PF -5390 6397
ATP5F1D -8493 2982
ATP5MC2 -7917 2992
ATP5ME -8857 2655
ATP5PO -3036 4812
ATP5F1B -1679 6433

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t0_v_pod pod_crp t0_crp
ATP5F1A 6445 706.5 -6834
ATP5F1B 6433 7002.5 -1679
ATP5F1C 6536 5173.5 5626
ATP5F1D 2982 -629.5 -8493
ATP5F1E 6172 4595.5 -6758
ATP5MC1 -7337 -7231.5 -2458
ATP5MC2 2992 2067.5 -7917
ATP5MC3 5930 4952.5 -6641
ATP5ME 2655 3246.5 -8857
ATP5MF 6524 6409.5 -8533
ATP5MG 5540 2516.5 -8883
ATP5PB 7550 5437.5 -6217
ATP5PD 7543 6479.5 2029
ATP5PF 6397 5008.5 -5390
ATP5PO 4812 105.5 -3036
DMAC2L -7158 -3987.5 10780
MT-ATP6 -2061 -445.5 -6676
MT-ATP8 -2884 2539.5 -8683



Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

metric value
setSize 11
pMANOVA 0.019
p.adjustMANOVA 0.0391
s.dist 0.728
s.t0_v_pod 0.469
s.pod_crp 0.548
s.t0_crp 0.102
p.t0_v_pod 0.00712
p.pod_crp 0.00165
p.t0_crp 0.557




Gene pod_crp t0_v_pod
PIK3CB 9337.5 8915
LYN 10614.5 7614
IRS2 9803.5 8194
EPOR 10118.5 7059
GAB1 8063.5 5652
PIK3CD 7390.5 6012
PIK3CG 9150.5 2032
PIK3CA 2767.5 4647
JAK2 3413.5 2582

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
EPOR 7059 10118.5 1562
GAB1 5652 8063.5 10464
IRS2 8194 9803.5 -1722
JAK2 2582 3413.5 12239
LYN 7614 10614.5 10317
PIK3CA 4647 2767.5 6848
PIK3CB 8915 9337.5 5556
PIK3CD 6012 7390.5 -7478
PIK3CG 2032 9150.5 82
PIK3R1 -9405 -8047.5 -3289
PIK3R5 -2293 5634.5 -4989



Dissolution of Fibrin Clot

metric value
setSize 12
pMANOVA 0.00763
p.adjustMANOVA 0.0178
s.dist 0.728
s.t0_v_pod 0.562
s.pod_crp 0.454
s.t0_crp -0.0893
p.t0_v_pod 0.000752
p.pod_crp 0.0065
p.t0_crp 0.592




Gene t0_v_pod pod_crp
SERPINB2 9331 10259.5
ANXA2 8294 10557.5
SERPINB8 9028 9495.5
PLAUR 8359 10069.5
S100A10 6690 7229.5
SERPINE1 7469 6378.5
SERPINE2 6415 6459.5
SERPINB6 5719 7004.5
PLAU 4921 3730.5

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t0_v_pod pod_crp t0_crp
ANXA2 8294 10557.5 5142
PLAT -1216 -5806.5 4877
PLAU 4921 3730.5 -4348
PLAUR 8359 10069.5 -706
PLG -1957 -648.5 9889
S100A10 6690 7229.5 -512
SERPINB2 9331 10259.5 4251
SERPINB6 5719 7004.5 -5171
SERPINB8 9028 9495.5 4636
SERPINE1 7469 6378.5 -2505
SERPINE2 6415 6459.5 -4474
SERPINF2 -6377 -2371.5 -3377



Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

metric value
setSize 22
pMANOVA 6.09e-06
p.adjustMANOVA 3.52e-05
s.dist 0.726
s.t0_v_pod 0.475
s.pod_crp 0.409
s.t0_crp -0.366
p.t0_v_pod 0.000113
p.pod_crp 0.000887
p.t0_crp 0.00299




Gene t0_v_pod pod_crp
H2AJ 9260.0 11022.5
H2BC21 9211.0 9169.5
H2BC12 9025.0 8965.5
H3-3A 8612.0 9279.5
H2BC4 7438.0 8876.5
H2BC5 8040.0 7278.5
H2BC11 7954.0 7009.5
H2AC6 7948.0 6588.5
H2BC17 7392.0 6731.5
H3C15 6686.5 6812.0
H2AC20 4981.0 7901.5
H2AZ1 6041.0 5160.5
AR 4856.0 6284.5
H2BC15 5393.0 5254.5
KLK2 3056.0 5364.5
NCOA2 1100.0 6393.5

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t0_v_pod pod_crp t0_crp
AR 4856.0 6284.5 4037.0
H2AC20 4981.0 7901.5 3484.0
H2AC6 7948.0 6588.5 -2700.0
H2AJ 9260.0 11022.5 -7169.0
H2AZ1 6041.0 5160.5 -8638.0
H2AZ2 -1249.0 -3740.5 -7449.0
H2BC11 7954.0 7009.5 -4404.0
H2BC12 9025.0 8965.5 -7638.0
H2BC15 5393.0 5254.5 -4378.0
H2BC17 7392.0 6731.5 -2437.0
H2BC21 9211.0 9169.5 -2181.0
H2BC4 7438.0 8876.5 -575.0
H2BC5 8040.0 7278.5 -4891.0
H2BC9 5396.0 -3277.5 -2834.0
H2BU1 -6302.0 -1745.5 -1518.0
H3-3A 8612.0 9279.5 1082.0
H3C15 6686.5 6812.0 -5402.5
KDM1A -9158.0 -7472.5 -5321.0
KDM4C -10177.0 -5408.5 -1116.0
KLK2 3056.0 5364.5 10131.0
NCOA2 1100.0 6393.5 5350.0
PKN1 -1946.0 7416.5 -6225.0



Generation of second messenger molecules

metric value
setSize 38
pMANOVA 3.79e-07
p.adjustMANOVA 3.07e-06
s.dist 0.725
s.t0_v_pod -0.463
s.pod_crp -0.499
s.t0_crp -0.252
p.t0_v_pod 7.92e-07
p.pod_crp 1.03e-07
p.t0_crp 0.0072




Gene pod_crp t0_v_pod
EVL -9895.5 -11686
TRBC1 -9646.5 -11503
LCK -9943.5 -11140
LAT -9821.5 -11027
ITK -9957.5 -10720
HLA-DRA -9127.5 -11648
TRAC -9950.5 -10637
ZAP70 -9167.5 -11477
CD247 -8658.5 -11933
CD3E -9657.5 -10696
HLA-DPB1 -8520.5 -11842
NCK1 -9019.5 -11136
TRBV12-3 -10084.5 -9947
PLCG1 -9869.5 -10137
HLA-DPA1 -8382.5 -11909
CD3G -8663.5 -11060
CD3D -8899.5 -10748
TRAV8-4 -10231.5 -9067
HLA-DQA1 -8064.5 -11408
HLA-DQB2 -9739.5 -9073

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CD101 4126 85.5 288
CD247 -11933 -8658.5 -7294
CD3D -10748 -8899.5 -1723
CD3E -10696 -9657.5 825
CD3G -11060 -8663.5 6100
CD4 -5145 -7068.5 -4207
ENAH -2695 1360.5 1838
EVL -11686 -9895.5 -4661
GRAP2 4695 -713.5 -6084
HLA-DPA1 -11909 -8382.5 4327
HLA-DPB1 -11842 -8520.5 -3185
HLA-DQA1 -11408 -8064.5 4681
HLA-DQA2 -4641 -8079.5 -8418
HLA-DQB1 -5513 -6016.5 -1593
HLA-DQB2 -9073 -9739.5 -7013
HLA-DRA -11648 -9127.5 2478
HLA-DRB1 -7880 -1220.5 8149
HLA-DRB5 -4971 922.5 7335
ITK -10720 -9957.5 -9
LAT -11027 -9821.5 -6276
LCK -11140 -9943.5 -7000
LCP2 -1152 3157.5 9430
NCK1 -11136 -9019.5 160
PAK1 8124 9588.5 9318
PAK2 8099 9157.5 7107
PAK3 -4064 -5598.5 -1486
PLCG1 -10137 -9869.5 -3286
PLCG2 5045 9642.5 -645
TRAC -10637 -9950.5 328
TRAV19 -9695 -9008.5 -3895
TRAV29DV5 -9017 -9622.5 -1671
TRAV8-4 -9067 -10231.5 -7960
TRBC1 -11503 -9646.5 -2158
TRBV12-3 -9947 -10084.5 -8593
TRBV7-9 -9246 -8367.5 -4513
VASP 8013 9875.5 -3798
WAS 8460 10250.5 -538
ZAP70 -11477 -9167.5 -7864



GRB2:SOS provides linkage to MAPK signaling for Integrins

metric value
setSize 12
pMANOVA 0.00509
p.adjustMANOVA 0.0126
s.dist 0.722
s.t0_v_pod 0.578
s.pod_crp 0.417
s.t0_crp 0.113
p.t0_v_pod 0.000527
p.pod_crp 0.0124
p.t0_crp 0.496




Gene t0_v_pod pod_crp
GRB2 9164 10574.5
APBB1IP 8705 10254.5
TLN1 8420 10166.5
ITGA2B 8796 8441.5
RAP1A 7212 8328.5
ITGB3 8237 5495.5
VWF 6516 5703.5
RAP1B 3302 8354.5
FN1 8165 315.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
APBB1IP 8705 10254.5 -854
FN1 8165 315.5 9070
GRB2 9164 10574.5 -1296
ITGA2B 8796 8441.5 2223
ITGB3 8237 5495.5 -2482
PTK2 4461 -229.5 1108
RAP1A 7212 8328.5 9770
RAP1B 3302 8354.5 8566
SOS1 -5524 -4203.5 11104
SRC -8705 -5564.5 1869
TLN1 8420 10166.5 -4313
VWF 6516 5703.5 -1068



RHO GTPases activate IQGAPs

metric value
setSize 11
pMANOVA 0.0148
p.adjustMANOVA 0.0318
s.dist 0.72
s.t0_v_pod 0.429
s.pod_crp 0.562
s.t0_crp 0.134
p.t0_v_pod 0.0137
p.pod_crp 0.00125
p.t0_crp 0.442




Gene pod_crp t0_v_pod
CTNNA1 10952.5 9082
RAC1 10538.5 8578
CLIP1 10394.5 8343
IQGAP1 9909.5 8062
CDC42 8935.5 7428
CTNNB1 8989.5 6372
IQGAP2 9155.5 6198
IQGAP3 4840.5 3477

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t0_v_pod pod_crp t0_crp
CALM1 -2006 776.5 2755
CDC42 7428 8935.5 7768
CDH1 -11159 2191.5 4047
CLIP1 8343 10394.5 11228
CTNNA1 9082 10952.5 3289
CTNNB1 6372 8989.5 1238
IQGAP1 8062 9909.5 517
IQGAP2 6198 9155.5 9462
IQGAP3 3477 4840.5 -6740
MEN1 -7982 -6800.5 -8052
RAC1 8578 10538.5 7795



EPHB-mediated forward signaling

metric value
setSize 32
pMANOVA 6.65e-06
p.adjustMANOVA 3.78e-05
s.dist 0.719
s.t0_v_pod 0.499
s.pod_crp 0.505
s.t0_crp 0.12
p.t0_v_pod 1.05e-06
p.pod_crp 7.75e-07
p.t0_crp 0.242




Gene pod_crp t0_v_pod
ARPC1B 10576.5 9147
ITSN1 10534.5 9033
ARPC1A 10679.5 8777
ACTB 10467.5 8910
RAC1 10538.5 8578
ARPC5 10217.5 8514
ACTG1 9603.5 8532
LYN 10614.5 7614
CFL1 9826.5 8115
RHOA 9816.5 8091
PAK1 9588.5 8124
ARPC3 9265.5 8180
ARPC4 9663.5 7492
ACTR2 9342.5 7711
ACTR3 9118.5 7769
LIMK2 8567.5 8063
ARPC2 9318.5 7340
CDC42 8935.5 7428
ROCK1 9040.5 7336
ROCK2 6998.5 6064

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ACTB 8910 10467.5 -889
ACTG1 8532 9603.5 -7489
ACTR2 7711 9342.5 8628
ACTR3 7769 9118.5 4171
ARHGEF28 -10143 2388.5 7228
ARPC1A 8777 10679.5 4453
ARPC1B 9147 10576.5 -5950
ARPC2 7340 9318.5 1060
ARPC3 8180 9265.5 5269
ARPC4 7492 9663.5 -3661
ARPC5 8514 10217.5 7082
CDC42 7428 8935.5 7768
CFL1 8115 9826.5 -6350
FYN -11403 -4493.5 -3087
HRAS -3240 -6003.5 -7632
ITSN1 9033 10534.5 11308
KALRN -3615 -7239.5 -1941
LIMK1 4690 8079.5 -3541
LIMK2 8063 8567.5 -3615
LYN 7614 10614.5 10317
PAK1 8124 9588.5 9318
PTK2 4461 -229.5 1108
RAC1 8578 10538.5 7795
RASA1 2120 5191.5 11098
RHOA 8091 9816.5 4832
ROCK1 7336 9040.5 11587
ROCK2 6064 6998.5 9646
SDC2 5197 4118.5 7699
SRC -8705 -5564.5 1869
TIAM1 694 -4155.5 -3551
WASL 282 1511.5 5487
YES1 -11782 -2770.5 1894



rRNA modification in the nucleus and cytosol

metric value
setSize 59
pMANOVA 6.32e-12
p.adjustMANOVA 9.55e-11
s.dist 0.718
s.t0_v_pod -0.397
s.pod_crp -0.537
s.t0_crp -0.263
p.t0_v_pod 1.37e-07
p.pod_crp 9.24e-13
p.t0_crp 0.000465




Gene pod_crp t0_v_pod
NAT10 -10101.5 -11508
DKC1 -10321.5 -11128
BMS1 -9837.5 -11259
NOP56 -9853.5 -11150
UTP4 -9930.5 -11042
DDX47 -9741.5 -10803
NOP14 -9836.5 -10583
NOL11 -10169.5 -9893
NOP58 -10146.5 -9707
FBL -10014.5 -9778
UTP15 -9487.5 -10212
WDR46 -9002.5 -10704
WDR75 -10092.5 -9487
THUMPD1 -9971.5 -9539
NOL6 -8619.5 -10505
EMG1 -8867.5 -9832
RRP9 -8788.5 -9725
IMP4 -8253.5 -10341
NOP2 -9188.5 -9186
UTP20 -8186.5 -10098

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BMS1 -11259 -9837.5 -3049
DCAF13 -5439 -6161.5 -1571
DDX47 -10803 -9741.5 3472
DDX49 4883 4133.5 -7546
DDX52 497 2715.5 12255
DHX37 -8019 -5530.5 -4867
DIMT1 -7807 -9429.5 8033
DKC1 -11128 -10321.5 -4947
EMG1 -9832 -8867.5 2684
FBL -9778 -10014.5 -9029
FCF1 4510 2971.5 3971
GAR1 -6778 -6732.5 -2718
HEATR1 -9924 -8126.5 2205
IMP3 -8978 -7554.5 -7770
IMP4 -10341 -8253.5 -8102
KRR1 -8302 -8139.5 6121
MPHOSPH10 -7610 -8478.5 11201
NAT10 -11508 -10101.5 -4796
NHP2 -3395 -6371.5 -8264
NOC4L -5327 1541.5 2328
NOL11 -9893 -10169.5 3608
NOL6 -10505 -8619.5 -4953
NOP10 8331 9945.5 -7324
NOP14 -10583 -9836.5 -4349
NOP2 -9186 -9188.5 -7692
NOP56 -11150 -9853.5 -4229
NOP58 -9707 -10146.5 7541
PDCD11 -11196 -6754.5 -5153
PNO1 -6716 -6607.5 9516
PWP2 -979 -537.5 -2293
RCL1 -827 -7181.5 -4488
RPS14 -5300 -7876.5 -8680
RPS2 -4365 -9114.5 -9084
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS9 5430 3499.5 -8091
RRP36 -1483 2381.5 -3338
RRP7A -2752 -3730.5 -4140
RRP9 -9725 -8788.5 -8383
SNORD3A -2249 9350.5 9071
SNU13 -6683 -8010.5 -8297
TBL3 -3372 -617.5 -6850
THUMPD1 -9539 -9971.5 7205
TRMT112 581 -2621.5 -9010
TSR3 3871 3345.5 -8960
UTP11 4659 2445.5 5799
UTP14A -1765 -1115.5 2230
UTP14C -1614 1103.5 7508
UTP15 -10212 -9487.5 9817
UTP18 5105 3913.5 584
UTP20 -10098 -8186.5 7274
UTP3 -2864 -4281.5 -5024
UTP4 -11042 -9930.5 -146
UTP6 -4379 -8202.5 5491
WDR3 -6376 -7406.5 -927
WDR36 -3725 -5865.5 4916
WDR43 -7301 -9654.5 -1341
WDR46 -10704 -9002.5 -8805
WDR75 -9487 -10092.5 7131



Budding and maturation of HIV virion

metric value
setSize 26
pMANOVA 4.54e-06
p.adjustMANOVA 2.74e-05
s.dist 0.717
s.t0_v_pod 0.526
s.pod_crp 0.428
s.t0_crp -0.234
p.t0_v_pod 3.49e-06
p.pod_crp 0.000161
p.t0_crp 0.0389




Gene t0_v_pod pod_crp
CHMP4B 8687 10119.5
UBAP1 8637 10158.5
CHMP2A 8718 9943.5
VPS37C 7853 10309.5
CHMP3 8209 9257.5
TSG101 7740 8125.5
NEDD4L 7852 7727.5
PDCD6IP 6494 8792.5
MVB12A 7317 7718.5
VPS37A 6469 7591.5
CHMP5 4897 9958.5
CHMP6 5523 7789.5
MVB12B 5191 8091.5
VTA1 6145 5888.5
VPS4B 5219 6170.5
UBC 4378 6962.5
CHMP2B 5643 5398.5
VPS37B 3895 7624.5
CHMP4A 2463 4763.5
UBB 6643 1475.5

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t0_v_pod pod_crp t0_crp
CHMP2A 8718 9943.5 -6037
CHMP2B 5643 5398.5 9665
CHMP3 8209 9257.5 3778
CHMP4A 2463 4763.5 2915
CHMP4B 8687 10119.5 -5957
CHMP5 4897 9958.5 11910
CHMP6 5523 7789.5 -8776
CHMP7 -8042 -9638.5 -5009
MVB12A 7317 7718.5 -6320
MVB12B 5191 8091.5 -563
NEDD4L 7852 7727.5 -5334
PDCD6IP 6494 8792.5 9948
PPIA -6664 -5154.5 -7862
RPS27A -6658 -9698.5 -9022
TSG101 7740 8125.5 5201
UBA52 1062 -2813.5 -8649
UBAP1 8637 10158.5 -2555
UBB 6643 1475.5 -6574
UBC 4378 6962.5 946
VPS28 4207 229.5 -8376
VPS37A 6469 7591.5 9884
VPS37B 3895 7624.5 -7863
VPS37C 7853 10309.5 3952
VPS4A 769 977.5 -8473
VPS4B 5219 6170.5 6600
VTA1 6145 5888.5 9121



Hyaluronan metabolism

metric value
setSize 13
pMANOVA 0.00462
p.adjustMANOVA 0.0115
s.dist 0.717
s.t0_v_pod 0.511
s.pod_crp 0.466
s.t0_crp -0.188
p.t0_v_pod 0.00141
p.pod_crp 0.00366
p.t0_crp 0.24




Gene t0_v_pod pod_crp
HYAL2 9005 10825.5
CHP1 9108 10229.5
SLC9A1 7895 10839.5
GUSB 7345 10841.5
CD44 8185 9369.5
HEXB 8607 8736.5
HYAL1 4255 8002.5
HMMR 4012 4804.5
HYAL3 5176 2035.5

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t0_v_pod pod_crp t0_crp
ABCC5 2517 -375.5 -5521
CD44 8185 9369.5 -1635
CEMIP -6983 -6132.5 1684
CHP1 9108 10229.5 -787
GUSB 7345 10841.5 -76
HAS3 -6009 881.5 -2724
HEXA 1264 -855.5 -4219
HEXB 8607 8736.5 856
HMMR 4012 4804.5 3507
HYAL1 4255 8002.5 9232
HYAL2 9005 10825.5 -6816
HYAL3 5176 2035.5 2399
SLC9A1 7895 10839.5 -1267



Processive synthesis on the lagging strand

metric value
setSize 15
pMANOVA 0.00411
p.adjustMANOVA 0.0105
s.dist 0.716
s.t0_v_pod -0.433
s.pod_crp -0.538
s.t0_crp -0.19
p.t0_v_pod 0.0037
p.pod_crp 0.000308
p.t0_crp 0.203




Gene pod_crp t0_v_pod
POLA1 -9972.5 -11760
RPA1 -9864.5 -11603
LIG1 -9954.5 -10136
POLD2 -10256.5 -9600
PRIM1 -9354.5 -9846
POLA2 -7969.5 -11286
RPA3 -8931.5 -8697
FEN1 -5934.5 -10402
PCNA -6623.5 -5838
PRIM2 -6436.5 -5431
RPA2 -4258.5 -6185
DNA2 -5876.5 -2807

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
DNA2 -2807 -5876.5 10746
FEN1 -10402 -5934.5 -5164
LIG1 -10136 -9954.5 -5819
PCNA -5838 -6623.5 1994
POLA1 -11760 -9972.5 -1080
POLA2 -11286 -7969.5 7922
POLD1 132 -4342.5 -8168
POLD2 -9600 -10256.5 -8327
POLD3 8570 10512.5 9422
POLD4 6339 8280.5 -7459
PRIM1 -9846 -9354.5 6363
PRIM2 -5431 -6436.5 47
RPA1 -11603 -9864.5 -6611
RPA2 -6185 -4258.5 657
RPA3 -8697 -8931.5 -1025



Spry regulation of FGF signaling

metric value
setSize 16
pMANOVA 0.000322
p.adjustMANOVA 0.00116
s.dist 0.713
s.t0_v_pod 0.472
s.pod_crp 0.407
s.t0_crp -0.347
p.t0_v_pod 0.00108
p.pod_crp 0.00479
p.t0_crp 0.0163




Gene t0_v_pod pod_crp
GRB2 9164 10574.5
MKNK1 8120 10043.5
MAPK1 7410 10809.5
MAPK3 8928 8957.5
CBL 7487 9438.5
PPP2CA 8179 7755.5
PPP2CB 7654 8182.5
PTPN11 5322 7012.5
UBC 4378 6962.5
PPP2R1A 4621 5445.5
UBB 6643 1475.5
BRAF 1304 3015.5

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t0_v_pod pod_crp t0_crp
BRAF 1304 3015.5 4234
CBL 7487 9438.5 -3450
GRB2 9164 10574.5 -1296
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
MKNK1 8120 10043.5 4370
PPP2CA 8179 7755.5 459
PPP2CB 7654 8182.5 4467
PPP2R1A 4621 5445.5 -8081
PTPN11 5322 7012.5 2127
RPS27A -6658 -9698.5 -9022
SPRY2 -4708 3608.5 -6737
SRC -8705 -5564.5 1869
UBA52 1062 -2813.5 -8649
UBB 6643 1475.5 -6574
UBC 4378 6962.5 946



Cargo concentration in the ER

metric value
setSize 30
pMANOVA 1.4e-05
p.adjustMANOVA 7.35e-05
s.dist 0.711
s.t0_v_pod 0.518
s.pod_crp 0.486
s.t0_crp 0.0478
p.t0_v_pod 9.21e-07
p.pod_crp 4.1e-06
p.t0_crp 0.65




Gene t0_v_pod pod_crp
F5 9363 11013.5
SERPINA1 9026 10996.5
TGFA 8881 10404.5
CTSZ 8852 9923.5
SEC24D 8007 10545.5
SEC24A 7602 9158.5
LMAN2 7073 9192.5
STX5 7081 8815.5
PREB 6360 9389.5
F8 6895 8604.5
SEC23A 7308 7450.5
SAR1B 6471 7500.5
MIA2 5550 8345.5
COL7A1 6286 6741.5
MCFD2 7032 5892.5
TMED2 6014 6794.5
AREG 5428 5770.5
CD59 5885 4869.5
SEC22B 5860 4361.5
CTSC 2530 9602.5

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t0_v_pod pod_crp t0_crp
AREG 5428 5770.5 -1772
CD59 5885 4869.5 -5821
CNIH1 7716 1409.5 -1979
CNIH2 720 1610.5 1903
CNIH3 -8881 -3886.5 -1656
COL7A1 6286 6741.5 -5294
CTSC 2530 9602.5 4989
CTSZ 8852 9923.5 -5150
F5 9363 11013.5 8184
F8 6895 8604.5 7160
GOSR2 -1480 2242.5 2378
LMAN1 -10361 -8874.5 10429
LMAN2 7073 9192.5 -4635
LMAN2L 6902 2263.5 -8305
MCFD2 7032 5892.5 -975
MIA2 5550 8345.5 11834
MIA3 -6122 -4362.5 11449
PREB 6360 9389.5 -6271
SAR1B 6471 7500.5 11822
SEC22B 5860 4361.5 9958
SEC23A 7308 7450.5 6004
SEC24A 7602 9158.5 8698
SEC24B 3620 6288.5 6702
SEC24C -2550 6654.5 -3832
SEC24D 8007 10545.5 7679
SERPINA1 9026 10996.5 8618
STX5 7081 8815.5 -4898
TGFA 8881 10404.5 -6928
TMED10 326 -2643.5 -4208
TMED2 6014 6794.5 7120



Signal transduction by L1

metric value
setSize 20
pMANOVA 0.000295
p.adjustMANOVA 0.00107
s.dist 0.704
s.t0_v_pod 0.436
s.pod_crp 0.552
s.t0_crp 0.039
p.t0_v_pod 0.000742
p.pod_crp 1.91e-05
p.t0_crp 0.762




Gene pod_crp t0_v_pod
MAP2K1 10257.5 8813
RAC1 10538.5 8578
MAPK1 10809.5 7410
MAPK3 8957.5 8928
PAK1 9588.5 8124
ITGA2B 8441.5 8796
ITGA5 9332.5 7585
ITGA9 8864.5 6884
CSNK2A1 9264.5 6120
CSNK2A2 7681.5 6340
MAP2K2 7148.5 6808
ITGB3 5495.5 8237
ITGAV 7400.5 6048
CSNK2B 5702.5 3948

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t0_v_pod pod_crp t0_crp
CSNK2A1 6120 9264.5 2942
CSNK2A2 6340 7681.5 4413
CSNK2B 3948 5702.5 -125
FGFR1 -5158 6076.5 5953
ITGA2B 8796 8441.5 2223
ITGA5 7585 9332.5 -6170
ITGA9 6884 8864.5 7366
ITGAV 6048 7400.5 5665
ITGB1 -50 -848.5 7145
ITGB3 8237 5495.5 -2482
L1CAM -6027 -4077.5 7695
MAP2K1 8813 10257.5 -1581
MAP2K2 6808 7148.5 -8956
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
NCAM1 -11381 -2067.5 -5231
NRP1 -8570 4079.5 9970
PAK1 8124 9588.5 9318
RAC1 8578 10538.5 7795
VAV2 -3946 2288.5 2720



Resolution of AP sites via the multiple-nucleotide patch replacement pathway

metric value
setSize 24
pMANOVA 0.000228
p.adjustMANOVA 0.000866
s.dist 0.704
s.t0_v_pod -0.447
s.pod_crp -0.494
s.t0_crp -0.227
p.t0_v_pod 0.000152
p.pod_crp 2.79e-05
p.t0_crp 0.0538




Gene pod_crp t0_v_pod
RPA1 -9864.5 -11603
POLE3 -9037.5 -11290
PARP1 -8989.5 -11233
LIG1 -9954.5 -10136
APEX1 -10295.5 -9729
POLD2 -10256.5 -9600
RFC3 -9512.5 -10179
RFC4 -9337.5 -10175
RFC5 -7690.5 -11399
PARP2 -7445.5 -11766
RPA3 -8931.5 -8697
POLE2 -7226.5 -9781
FEN1 -5934.5 -10402
POLB -7356.5 -7403
POLE -5308.5 -7316
PCNA -6623.5 -5838
RPA2 -4258.5 -6185
RFC1 -3251.5 -7269

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
APEX1 -9729 -10295.5 -8308
FEN1 -10402 -5934.5 -5164
LIG1 -10136 -9954.5 -5819
PARG -693 1305.5 1279
PARP1 -11233 -8989.5 -6608
PARP2 -11766 -7445.5 4594
PCNA -5838 -6623.5 1994
POLB -7403 -7356.5 9871
POLD1 132 -4342.5 -8168
POLD2 -9600 -10256.5 -8327
POLD3 8570 10512.5 9422
POLD4 6339 8280.5 -7459
POLE -7316 -5308.5 2249
POLE2 -9781 -7226.5 10374
POLE3 -11290 -9037.5 -7990
POLE4 5544 535.5 -6493
RFC1 -7269 -3251.5 9849
RFC2 4982 6761.5 -4032
RFC3 -10179 -9512.5 875
RFC4 -10175 -9337.5 1350
RFC5 -11399 -7690.5 3523
RPA1 -11603 -9864.5 -6611
RPA2 -6185 -4258.5 657
RPA3 -8697 -8931.5 -1025



RHO GTPases activate PAKs

metric value
setSize 20
pMANOVA 0.00106
p.adjustMANOVA 0.00327
s.dist 0.703
s.t0_v_pod 0.483
s.pod_crp 0.504
s.t0_crp 0.0846
p.t0_v_pod 0.000187
p.pod_crp 9.54e-05
p.t0_crp 0.513




Gene pod_crp t0_v_pod
RAC1 10538.5 8578
MYL6 10014.5 8547
PAK1 9588.5 8124
PAK2 9157.5 8099
CDC42 8935.5 7428
MYH9 8971.5 6678
PPP1CB 7433.5 6990
PPP1R12A 8180.5 6046
MYL9 5473.5 7605
LIMK1 8079.5 4690
MYL12B 6824.5 5119
MYLK 4126.5 6596
CTTN 1624.5 5919
PPP1R12B 5119.5 1724
FLNA 8378.5 542
MYH10 6149.5 658

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t0_v_pod pod_crp t0_crp
CALM1 -2006 776.5 2755
CDC42 7428 8935.5 7768
CTTN 5919 1624.5 -2897
FLNA 542 8378.5 324
LIMK1 4690 8079.5 -3541
MYH10 658 6149.5 5118
MYH11 -3387 -3208.5 5759
MYH9 6678 8971.5 -4854
MYL12B 5119 6824.5 -2978
MYL6 8547 10014.5 -8390
MYL9 7605 5473.5 4521
MYLK 6596 4126.5 3200
NF2 -6388 4065.5 583
PAK1 8124 9588.5 9318
PAK2 8099 9157.5 7107
PAK3 -4064 -5598.5 -1486
PPP1CB 6990 7433.5 9292
PPP1R12A 6046 8180.5 9594
PPP1R12B 1724 5119.5 994
RAC1 8578 10538.5 7795



Influenza Infection

metric value
setSize 154
pMANOVA 8.11e-43
p.adjustMANOVA 4.08e-41
s.dist 0.703
s.t0_v_pod -0.184
s.pod_crp -0.451
s.t0_crp -0.507
p.t0_v_pod 8.03e-05
p.pod_crp 4.42e-22
p.t0_crp 1.64e-27




Gene t0_crp pod_crp
RPL3 -8984 -9970.5
RPL14 -8971 -9780.5
RPS27A -9022 -9698.5
RPS25 -8793 -9664.5
RPLP2 -9085 -9244.5
RPS27 -8998 -9300.5
RPL5 -8450 -9893.5
RPS6 -8694 -9602.5
RPS2 -9084 -9114.5
RPS3 -9021 -9149.5
RPL32 -8747 -9346.5
RPS12 -9041 -9016.5
RPS5 -8931 -9110.5
RPL7 -8731 -9317.5
RPS29 -9075 -8819.5
RPS23 -8770 -9063.5
RPL23A -7855 -10055.5
RPL30 -8940 -8740.5
RPL22 -8315 -9383.5
RPL12 -8723 -8888.5

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t0_v_pod pod_crp t0_crp
AAAS -8054 -4779.5 -4358
CALR 6325 7383.5 3934
CANX 5460 5482.5 3517
CLTA 8272 8299.5 -3488
CLTC 8906 10209.5 776
CPSF4 -9296 -4090.5 -6258
DNAJC3 8337 9705.5 7588
EIF2AK2 -9078 4326.5 12270
FAU -398 -3107.5 -8957
GRSF1 5173 108.5 1948
GTF2F1 4984 6928.5 -7059
GTF2F2 5437 7006.5 1993
HSP90AA1 1338 -1973.5 6514
HSPA1A 8054 8763.5 -5033
IPO5 -10340 -10292.5 -2989
ISG15 -11738 -5299.5 11943
KPNA1 1310 -1226.5 6458
KPNA2 -6611 216.5 7967
KPNA3 949 -40.5 8302
KPNA4 5016 6231.5 8850
KPNA5 -11505 -9298.5 10886
KPNB1 2474 5655.5 8917
NDC1 -11752 -10241.5 283
NUP107 -10234 -8189.5 9188
NUP133 -7569 -5650.5 1394
NUP153 -6117 -1929.5 635
NUP155 -9959 -7484.5 4716
NUP160 -10049 -9039.5 3294
NUP188 -11192 -8612.5 -4784
NUP205 -10902 -8251.5 -205
NUP210 -10387 -5194.5 -5639
NUP214 7891 9278.5 1996
NUP35 -9876 -10046.5 -2752
NUP37 3126 366.5 -1383
NUP42 -5434 -3311.5 10712
NUP43 -9276 -8527.5 9596
NUP50 4499 4003.5 9103
NUP54 -8230 -7581.5 11428
NUP58 8727 9397.5 8050
NUP62 765 -3073.5 -3415
NUP85 -2996 -3252.5 4188
NUP88 -10700 -10009.5 -1806
NUP93 -11346 -5296.5 9018
NUP98 3098 4012.5 229
PABPN1 -521 -1128.5 -5745
PARP1 -11233 -8989.5 -6608
POLR2A -3022 6845.5 143
POLR2B -2474 -2457.5 1585
POLR2C 1518 -1408.5 -7182
POLR2D -3931 -5787.5 4203
POLR2E 7547 6080.5 -8394
POLR2F 4598 4075.5 -8724
POLR2G 3548 4752.5 -8433
POLR2H -2745 -6952.5 -7995
POLR2I 314 -3631.5 -8535
POLR2J 6675 5210.5 -8301
POLR2K -1760 -3462.5 5197
POLR2L 5301 2246.5 -9054
POM121 -7980 -2823.5 -4677
POM121C -7053 -1781.5 -5828
RAE1 5094 3686.5 -928
RAN -6638 -7719.5 -3813
RANBP2 -801 -2038.5 7972
RPL10 -6342 -8537.5 -8970
RPL10A -6417 -8696.5 -7778
RPL11 -6069 -8680.5 -8145
RPL12 -6795 -8888.5 -8723
RPL13 -3360 -6929.5 -7204
RPL13A -7844 -9353.5 -8240
RPL14 -6301 -9780.5 -8971
RPL15 -1005 -7294.5 -8759
RPL17 -5281 -8468.5 -8697
RPL18 -4889 -8557.5 -8908
RPL18A -5829 -8669.5 -8921
RPL19 -6037 -8013.5 -8716
RPL21 -6265 -9076.5 -8197
RPL22 -4586 -9383.5 -8315
RPL22L1 -1616 -6471.5 -1543
RPL23 -3257 -7768.5 -8474
RPL23A -9159 -10055.5 -7855
RPL24 -5689 -7985.5 -8065
RPL26 -6410 -8224.5 -8670
RPL26L1 7188 6612.5 -6307
RPL27 -2857 -7157.5 -9042
RPL27A -6114 -8484.5 -8938
RPL28 -1446 -2694.5 -5682
RPL29 -3498 -8267.5 -9009
RPL3 -8189 -9970.5 -8984
RPL30 -6754 -8740.5 -8940
RPL31 -4363 -8526.5 -9003
RPL32 -6355 -9346.5 -8747
RPL34 -6573 -9281.5 -7681
RPL35 -7956 -6747.5 -8002
RPL35A -5877 -8808.5 -8771
RPL36 -5113 -6965.5 -8993
RPL36A -7184 -8444.5 -8695
RPL36AL 90 -4223.5 -8319
RPL37 -6188 -7411.5 -9093
RPL37A -3879 -6166.5 -8974
RPL38 -5697 -7209.5 -9007
RPL39 -2966 -8236.5 -8765
RPL39L -8677 -2058.5 -6708
RPL3L 4494 4068.5 10513
RPL4 -3486 -9130.5 -8041
RPL41 -6641 -7232.5 -8909
RPL5 -4482 -9893.5 -8450
RPL6 -3285 -8577.5 -5474
RPL7 -1977 -9317.5 -8731
RPL7A -3589 -7709.5 -8975
RPL8 -1225 -5856.5 -9017
RPL9 -1794 -7371.5 -7034
RPLP0 -1040 -8473.5 -8944
RPLP1 -65 -5830.5 -9024
RPLP2 -6679 -9244.5 -9085
RPS10 -5497 -8385.5 -9032
RPS11 -6877 -7986.5 -9014
RPS12 -5788 -9016.5 -9041
RPS13 -1731 -8239.5 -8659
RPS14 -5300 -7876.5 -8680
RPS15 -3588 -6092.5 -8429
RPS15A -5505 -8640.5 -8955
RPS16 -4424 -8515.5 -8966
RPS17 -6018 -8041.5 -9077
RPS18 -7380 -8380.5 -8554
RPS19 -6794 -7098.5 -8647
RPS2 -4365 -9114.5 -9084
RPS20 -8618 -9180.5 -7998
RPS21 -3988 -7972.5 -9038
RPS23 -6073 -9063.5 -8770
RPS24 -282 -5499.5 -5439
RPS25 -6041 -9664.5 -8793
RPS26 -1420 -1552.5 -1434
RPS27 -9332 -9300.5 -8998
RPS27A -6658 -9698.5 -9022
RPS27L 2103 1014.5 8557
RPS28 -4498 -7992.5 -8958
RPS29 -7524 -8819.5 -9075
RPS3 -5640 -9149.5 -9021
RPS3A -4550 -9630.5 -6511
RPS4X -5772 -8917.5 -7904
RPS4Y1 -222 10164.5 12286
RPS5 -5294 -9110.5 -8931
RPS6 -5897 -9602.5 -8694
RPS7 -4852 -8531.5 -8575
RPS8 -2093 -8063.5 -8045
RPS9 5430 3499.5 -8091
RPSA -6014 -6886.5 -1637
SEC13 5745 6316.5 -5667
SEH1L -5760 -9805.5 6177
SLC25A6 6251 -3259.5 -9094
TGFB1 5142 6426.5 -6006
TPR -6856 -4470.5 9152
UBA52 1062 -2813.5 -8649
XPO1 -1183 -2525.5 11300



Lagging Strand Synthesis

metric value
setSize 20
pMANOVA 0.000946
p.adjustMANOVA 0.00294
s.dist 0.701
s.t0_v_pod -0.454
s.pod_crp -0.52
s.t0_crp -0.126
p.t0_v_pod 0.000437
p.pod_crp 5.73e-05
p.t0_crp 0.33




Gene pod_crp t0_v_pod
POLA1 -9972.5 -11760
RPA1 -9864.5 -11603
LIG1 -9954.5 -10136
POLD2 -10256.5 -9600
RFC3 -9512.5 -10179
RFC4 -9337.5 -10175
PRIM1 -9354.5 -9846
POLA2 -7969.5 -11286
RFC5 -7690.5 -11399
RPA3 -8931.5 -8697
FEN1 -5934.5 -10402
PCNA -6623.5 -5838
PRIM2 -6436.5 -5431
RPA2 -4258.5 -6185
RFC1 -3251.5 -7269
DNA2 -5876.5 -2807

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
DNA2 -2807 -5876.5 10746
FEN1 -10402 -5934.5 -5164
LIG1 -10136 -9954.5 -5819
PCNA -5838 -6623.5 1994
POLA1 -11760 -9972.5 -1080
POLA2 -11286 -7969.5 7922
POLD1 132 -4342.5 -8168
POLD2 -9600 -10256.5 -8327
POLD3 8570 10512.5 9422
POLD4 6339 8280.5 -7459
PRIM1 -9846 -9354.5 6363
PRIM2 -5431 -6436.5 47
RFC1 -7269 -3251.5 9849
RFC2 4982 6761.5 -4032
RFC3 -10179 -9512.5 875
RFC4 -10175 -9337.5 1350
RFC5 -11399 -7690.5 3523
RPA1 -11603 -9864.5 -6611
RPA2 -6185 -4258.5 657
RPA3 -8697 -8931.5 -1025



Diseases associated with the TLR signaling cascade

metric value
setSize 23
pMANOVA 0.000178
p.adjustMANOVA 0.000701
s.dist 0.699
s.t0_v_pod 0.535
s.pod_crp 0.449
s.t0_crp -0.00317
p.t0_v_pod 8.91e-06
p.pod_crp 0.000191
p.t0_crp 0.979




Gene t0_v_pod pod_crp
CD36 9326 10630.5
TLR5 9099 10705.5
TLR2 8919 10240.5
MYD88 7969 10874.5
TLR4 8833 9619.5
TLR1 8891 9510.5
LY96 8726 9505.5
CD14 9013 9117.5
BTK 7051 10605.5
TLR6 8785 8476.5
CHUK 7840 8766.5
TICAM1 6291 7643.5
TIRAP 5630 8500.5
IKBKG 5371 8883.5
UNC93B1 4094 10129.5
NFKBIA 6740 4500.5
NFKB1 6278 2931.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BTK 7051 10605.5 9588
CD14 9013 9117.5 -5241
CD36 9326 10630.5 3514
CHUK 7840 8766.5 8068
IKBKB -5116 -1389.5 -437
IKBKG 5371 8883.5 -3285
LY96 8726 9505.5 6701
MYD88 7969 10874.5 8291
NFKB1 6278 2931.5 -1910
NFKB2 -857 -5864.5 -4873
NFKBIA 6740 4500.5 -5630
RELA -1774 -966.5 -6094
TICAM1 6291 7643.5 5202
TIRAP 5630 8500.5 248
TLR1 8891 9510.5 5914
TLR10 -2823 -8123.5 -6447
TLR2 8919 10240.5 8626
TLR3 -11185 -7679.5 4420
TLR4 8833 9619.5 3466
TLR5 9099 10705.5 6750
TLR6 8785 8476.5 -39
TRAF3 -5121 -8230.5 -6997
UNC93B1 4094 10129.5 6094



Diseases of Immune System

metric value
setSize 23
pMANOVA 0.000178
p.adjustMANOVA 0.000701
s.dist 0.699
s.t0_v_pod 0.535
s.pod_crp 0.449
s.t0_crp -0.00317
p.t0_v_pod 8.91e-06
p.pod_crp 0.000191
p.t0_crp 0.979




Gene t0_v_pod pod_crp
CD36 9326 10630.5
TLR5 9099 10705.5
TLR2 8919 10240.5
MYD88 7969 10874.5
TLR4 8833 9619.5
TLR1 8891 9510.5
LY96 8726 9505.5
CD14 9013 9117.5
BTK 7051 10605.5
TLR6 8785 8476.5
CHUK 7840 8766.5
TICAM1 6291 7643.5
TIRAP 5630 8500.5
IKBKG 5371 8883.5
UNC93B1 4094 10129.5
NFKBIA 6740 4500.5
NFKB1 6278 2931.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BTK 7051 10605.5 9588
CD14 9013 9117.5 -5241
CD36 9326 10630.5 3514
CHUK 7840 8766.5 8068
IKBKB -5116 -1389.5 -437
IKBKG 5371 8883.5 -3285
LY96 8726 9505.5 6701
MYD88 7969 10874.5 8291
NFKB1 6278 2931.5 -1910
NFKB2 -857 -5864.5 -4873
NFKBIA 6740 4500.5 -5630
RELA -1774 -966.5 -6094
TICAM1 6291 7643.5 5202
TIRAP 5630 8500.5 248
TLR1 8891 9510.5 5914
TLR10 -2823 -8123.5 -6447
TLR2 8919 10240.5 8626
TLR3 -11185 -7679.5 4420
TLR4 8833 9619.5 3466
TLR5 9099 10705.5 6750
TLR6 8785 8476.5 -39
TRAF3 -5121 -8230.5 -6997
UNC93B1 4094 10129.5 6094



MAP2K and MAPK activation

metric value
setSize 34
pMANOVA 1.31e-06
p.adjustMANOVA 9.36e-06
s.dist 0.695
s.t0_v_pod 0.517
s.pod_crp 0.453
s.t0_crp -0.105
p.t0_v_pod 1.81e-07
p.pod_crp 4.82e-06
p.t0_crp 0.29




Gene t0_v_pod pod_crp
MAP2K1 8813 10257.5
APBB1IP 8705 10254.5
MARK3 8632 10157.5
ARRB2 8385 10251.5
TLN1 8420 10166.5
MAPK1 7410 10809.5
MAPK3 8928 8957.5
IQGAP1 8062 9909.5
ITGA2B 8796 8441.5
RAF1 7871 8524.5
LAMTOR2 7590 8466.5
RAP1A 7212 8328.5
VCL 7273 7218.5
LAMTOR3 7579 6491.5
MAP2K2 6808 7148.5
CSK 5225 8794.5
ITGB3 8237 5495.5
YWHAB 6309 7043.5
KSR1 4074 9666.5
VWF 6516 5703.5

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t0_v_pod pod_crp t0_crp
APBB1IP 8705 10254.5 -854
ARAF 2662 5267.5 -3994
ARRB1 2084 5457.5 -6872
ARRB2 8385 10251.5 -4748
BRAF 1304 3015.5 4234
CNKSR1 -6623 -8731.5 -432
CNKSR2 -4338 -6186.5 1004
CSK 5225 8794.5 -6733
FN1 8165 315.5 9070
HRAS -3240 -6003.5 -7632
IQGAP1 8062 9909.5 517
ITGA2B 8796 8441.5 2223
ITGB3 8237 5495.5 -2482
KRAS 3723 6438.5 11041
KSR1 4074 9666.5 7718
KSR2 -3268 -615.5 2425
LAMTOR2 7590 8466.5 -8684
LAMTOR3 7579 6491.5 5787
MAP2K1 8813 10257.5 -1581
MAP2K2 6808 7148.5 -8956
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
MARK3 8632 10157.5 10084
NRAS 5348 6249.5 9510
PEBP1 -10922 -9946.5 -2213
RAF1 7871 8524.5 -1051
RAP1A 7212 8328.5 9770
RAP1B 3302 8354.5 8566
SRC -8705 -5564.5 1869
TLN1 8420 10166.5 -4313
VCL 7273 7218.5 -1287
VWF 6516 5703.5 -1068
WDR83 3764 6139.5 -6120
YWHAB 6309 7043.5 9812



Endosomal Sorting Complex Required For Transport (ESCRT)

metric value
setSize 29
pMANOVA 6.38e-06
p.adjustMANOVA 3.66e-05
s.dist 0.694
s.t0_v_pod 0.519
s.pod_crp 0.436
s.t0_crp -0.15
p.t0_v_pod 1.29e-06
p.pod_crp 4.89e-05
p.t0_crp 0.161




Gene t0_v_pod pod_crp
CHMP4B 8687 10119.5
UBAP1 8637 10158.5
CHMP2A 8718 9943.5
VPS37C 7853 10309.5
CHMP3 8209 9257.5
VPS25 7582 9313.5
TSG101 7740 8125.5
MVB12A 7317 7718.5
VPS37A 6469 7591.5
CHMP5 4897 9958.5
STAM2 6096 7428.5
CHMP6 5523 7789.5
MVB12B 5191 8091.5
SNF8 5910 6865.5
VTA1 6145 5888.5
HGS 4524 7671.5
VPS4B 5219 6170.5
UBC 4378 6962.5
CHMP2B 5643 5398.5
VPS37B 3895 7624.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CHMP2A 8718 9943.5 -6037
CHMP2B 5643 5398.5 9665
CHMP3 8209 9257.5 3778
CHMP4A 2463 4763.5 2915
CHMP4B 8687 10119.5 -5957
CHMP5 4897 9958.5 11910
CHMP6 5523 7789.5 -8776
CHMP7 -8042 -9638.5 -5009
HGS 4524 7671.5 361
MVB12A 7317 7718.5 -6320
MVB12B 5191 8091.5 -563
RPS27A -6658 -9698.5 -9022
SNF8 5910 6865.5 -5559
STAM 1289 1180.5 6671
STAM2 6096 7428.5 11573
TSG101 7740 8125.5 5201
UBA52 1062 -2813.5 -8649
UBAP1 8637 10158.5 -2555
UBB 6643 1475.5 -6574
UBC 4378 6962.5 946
VPS25 7582 9313.5 -4926
VPS28 4207 229.5 -8376
VPS36 -6704 -3859.5 11824
VPS37A 6469 7591.5 9884
VPS37B 3895 7624.5 -7863
VPS37C 7853 10309.5 3952
VPS4A 769 977.5 -8473
VPS4B 5219 6170.5 6600
VTA1 6145 5888.5 9121



PCNA-Dependent Long Patch Base Excision Repair

metric value
setSize 21
pMANOVA 0.000866
p.adjustMANOVA 0.00275
s.dist 0.69
s.t0_v_pod -0.422
s.pod_crp -0.492
s.t0_crp -0.235
p.t0_v_pod 0.000821
p.pod_crp 9.36e-05
p.t0_crp 0.0621




Gene pod_crp t0_v_pod
RPA1 -9864.5 -11603
POLE3 -9037.5 -11290
LIG1 -9954.5 -10136
APEX1 -10295.5 -9729
POLD2 -10256.5 -9600
RFC3 -9512.5 -10179
RFC4 -9337.5 -10175
RFC5 -7690.5 -11399
RPA3 -8931.5 -8697
POLE2 -7226.5 -9781
FEN1 -5934.5 -10402
POLB -7356.5 -7403
POLE -5308.5 -7316
PCNA -6623.5 -5838
RPA2 -4258.5 -6185
RFC1 -3251.5 -7269

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
APEX1 -9729 -10295.5 -8308
FEN1 -10402 -5934.5 -5164
LIG1 -10136 -9954.5 -5819
PCNA -5838 -6623.5 1994
POLB -7403 -7356.5 9871
POLD1 132 -4342.5 -8168
POLD2 -9600 -10256.5 -8327
POLD3 8570 10512.5 9422
POLD4 6339 8280.5 -7459
POLE -7316 -5308.5 2249
POLE2 -9781 -7226.5 10374
POLE3 -11290 -9037.5 -7990
POLE4 5544 535.5 -6493
RFC1 -7269 -3251.5 9849
RFC2 4982 6761.5 -4032
RFC3 -10179 -9512.5 875
RFC4 -10175 -9337.5 1350
RFC5 -11399 -7690.5 3523
RPA1 -11603 -9864.5 -6611
RPA2 -6185 -4258.5 657
RPA3 -8697 -8931.5 -1025



Pre-NOTCH Processing in Golgi

metric value
setSize 18
pMANOVA 0.000112
p.adjustMANOVA 0.000457
s.dist 0.688
s.t0_v_pod 0.41
s.pod_crp 0.468
s.t0_crp -0.293
p.t0_v_pod 0.00262
p.pod_crp 0.00058
p.t0_crp 0.0315




Gene pod_crp t0_v_pod
FURIN 10589.5 9011
NOTCH3 11002.5 7884
RAB6A 9805.5 8096
ATP2A2 9688.5 7949
ST3GAL4 9727.5 5851
SEL1L 8074.5 6739
TMED2 6794.5 6014
NOTCH2 7682.5 5216
NOTCH1 7940.5 4682
B4GALT1 8310.5 4312
ST3GAL6 3737.5 6578
RFNG 3219.5 7210

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t0_v_pod pod_crp t0_crp
ATP2A1 -4296 -294.5 889
ATP2A2 7949 9688.5 2218
ATP2A3 -987 1644.5 -6416
B4GALT1 4312 8310.5 -4129
FURIN 9011 10589.5 -8663
LFNG -8211 449.5 -3976
MFNG -5745 -7682.5 -9068
NOTCH1 4682 7940.5 -6870
NOTCH2 5216 7682.5 -574
NOTCH3 7884 11002.5 644
NOTCH4 -5029 9448.5 2737
RAB6A 8096 9805.5 6358
RFNG 7210 3219.5 -8032
SEL1L 6739 8074.5 4903
ST3GAL3 480 -3792.5 -4840
ST3GAL4 5851 9727.5 -7736
ST3GAL6 6578 3737.5 7870
TMED2 6014 6794.5 7120



Negative regulation of MET activity

metric value
setSize 18
pMANOVA 0.00165
p.adjustMANOVA 0.00486
s.dist 0.686
s.t0_v_pod 0.525
s.pod_crp 0.44
s.t0_crp -0.0327
p.t0_v_pod 0.000114
p.pod_crp 0.00123
p.t0_crp 0.81




Gene t0_v_pod pod_crp
GRB2 9164 10574.5
HGF 8712 10120.5
PTPRJ 7717 10192.5
CBL 7487 9438.5
PTPN2 7521 9288.5
SH3GL1 7618 8529.5
PTPN1 5723 10218.5
USP8 6294 7585.5
STAM2 6096 7428.5
SH3KBP1 6140 6877.5
HGS 4524 7671.5
UBC 4378 6962.5
EPS15 4150 6050.5
UBB 6643 1475.5
STAM 1289 1180.5

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t0_v_pod pod_crp t0_crp
CBL 7487 9438.5 -3450
EPS15 4150 6050.5 11171
GRB2 9164 10574.5 -1296
HGF 8712 10120.5 10790
HGS 4524 7671.5 361
LRIG1 -9885 -10174.5 -2828
PTPN1 5723 10218.5 3616
PTPN2 7521 9288.5 7349
PTPRJ 7717 10192.5 -3019
RPS27A -6658 -9698.5 -9022
SH3GL1 7618 8529.5 -7869
SH3KBP1 6140 6877.5 518
STAM 1289 1180.5 6671
STAM2 6096 7428.5 11573
UBA52 1062 -2813.5 -8649
UBB 6643 1475.5 -6574
UBC 4378 6962.5 946
USP8 6294 7585.5 12154



Packaging Of Telomere Ends

metric value
setSize 20
pMANOVA 2.49e-05
p.adjustMANOVA 0.000121
s.dist 0.686
s.t0_v_pod 0.451
s.pod_crp 0.307
s.t0_crp -0.415
p.t0_v_pod 0.000479
p.pod_crp 0.0173
p.t0_crp 0.0013




Gene t0_v_pod t0_crp
H2BC12 9025 -7638
H2AJ 9260 -7169
H2AZ1 6041 -8638
H2BC5 8040 -4891
H2BC11 7954 -4404
TINF2 4619 -6338
TERF2IP 5060 -5204
H2BC15 5393 -4378
H2AC6 7948 -2700
H2BC21 9211 -2181
H2BC17 7392 -2437
H2BC9 5396 -2834
H2BC4 7438 -575

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ACD -7369 -6644.5 -7999
H2AC20 4981 7901.5 3484
H2AC6 7948 6588.5 -2700
H2AJ 9260 11022.5 -7169
H2AZ1 6041 5160.5 -8638
H2AZ2 -1249 -3740.5 -7449
H2BC11 7954 7009.5 -4404
H2BC12 9025 8965.5 -7638
H2BC15 5393 5254.5 -4378
H2BC17 7392 6731.5 -2437
H2BC21 9211 9169.5 -2181
H2BC4 7438 8876.5 -575
H2BC5 8040 7278.5 -4891
H2BC9 5396 -3277.5 -2834
H2BU1 -6302 -1745.5 -1518
POT1 -4256 -4016.5 8747
TERF1 -3443 -334.5 6009
TERF2 -4371 -3876.5 1324
TERF2IP 5060 4732.5 -5204
TINF2 4619 7609.5 -6338



Prolonged ERK activation events

metric value
setSize 13
pMANOVA 0.0133
p.adjustMANOVA 0.0293
s.dist 0.684
s.t0_v_pod 0.451
s.pod_crp 0.514
s.t0_crp 0.018
p.t0_v_pod 0.00489
p.pod_crp 0.00133
p.t0_crp 0.91




Gene pod_crp t0_v_pod
MAP2K1 10257.5 8813
CRK 10204.5 8795
MAPK1 10809.5 7410
MAPK3 8957.5 8928
KIDINS220 9026.5 7008
RAP1A 8328.5 7212
MAP2K2 7148.5 6808
YWHAB 7043.5 6309
CRKL 4286.5 3947
BRAF 3015.5 1304

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
BRAF 1304 3015.5 4234
CRK 8795 10204.5 6988
CRKL 3947 4286.5 -3487
FRS2 -3332 -2604.5 6871
KIDINS220 7008 9026.5 5474
MAP2K1 8813 10257.5 -1581
MAP2K2 6808 7148.5 -8956
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
NTRK1 -7521 -5181.5 7616
RAP1A 7212 8328.5 9770
RAPGEF1 -9705 4657.5 -5090
YWHAB 6309 7043.5 9812



IRAK1 recruits IKK complex

metric value
setSize 10
pMANOVA 0.0388
p.adjustMANOVA 0.0716
s.dist 0.683
s.t0_v_pod 0.528
s.pod_crp 0.434
s.t0_crp 0.0106
p.t0_v_pod 0.00383
p.pod_crp 0.0176
p.t0_crp 0.953




Gene t0_v_pod pod_crp
PELI3 7621 9170.5
CHUK 7840 8766.5
PELI2 8043 7150.5
IRAK1 6072 7874.5
IKBKG 5371 8883.5
PELI1 6505 5458.5
UBE2V1 5611 1953.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CHUK 7840 8766.5 8068
IKBKB -5116 -1389.5 -437
IKBKG 5371 8883.5 -3285
IRAK1 6072 7874.5 -5219
PELI1 6505 5458.5 8061
PELI2 8043 7150.5 5864
PELI3 7621 9170.5 -7891
TRAF6 -241 2807.5 5718
UBE2N 1937 -838.5 4128
UBE2V1 5611 1953.5 2091



IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

metric value
setSize 10
pMANOVA 0.0388
p.adjustMANOVA 0.0716
s.dist 0.683
s.t0_v_pod 0.528
s.pod_crp 0.434
s.t0_crp 0.0106
p.t0_v_pod 0.00383
p.pod_crp 0.0176
p.t0_crp 0.953




Gene t0_v_pod pod_crp
PELI3 7621 9170.5
CHUK 7840 8766.5
PELI2 8043 7150.5
IRAK1 6072 7874.5
IKBKG 5371 8883.5
PELI1 6505 5458.5
UBE2V1 5611 1953.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CHUK 7840 8766.5 8068
IKBKB -5116 -1389.5 -437
IKBKG 5371 8883.5 -3285
IRAK1 6072 7874.5 -5219
PELI1 6505 5458.5 8061
PELI2 8043 7150.5 5864
PELI3 7621 9170.5 -7891
TRAF6 -241 2807.5 5718
UBE2N 1937 -838.5 4128
UBE2V1 5611 1953.5 2091



RHO GTPases activate PKNs

metric value
setSize 47
pMANOVA 8.54e-09
p.adjustMANOVA 8.67e-08
s.dist 0.681
s.t0_v_pod 0.481
s.pod_crp 0.468
s.t0_crp -0.121
p.t0_v_pod 1.18e-08
p.pod_crp 2.87e-08
p.t0_crp 0.152




Gene t0_v_pod pod_crp
H2AJ 9260 11022.5
YWHAG 9154 10235.5
RAC1 8578 10538.5
YWHAH 8484 10319.5
MYL6 8547 10014.5
YWHAE 8860 9554.5
H2BC21 9211 9169.5
H2BC12 9025 8965.5
H3-3A 8612 9279.5
RHOA 8091 9816.5
PAK1 8124 9588.5
H2BC4 7438 8876.5
MYH9 6678 8971.5
H2BC5 8040 7278.5
H2BC11 7954 7009.5
H2AC6 7948 6588.5
PDPK1 6122 8512.5
PPP1CB 6990 7433.5
H2BC17 7392 6731.5
PPP1R12A 6046 8180.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
AR 4856.0 6284.5 4037.0
H2AC20 4981.0 7901.5 3484.0
H2AC6 7948.0 6588.5 -2700.0
H2AJ 9260.0 11022.5 -7169.0
H2AZ1 6041.0 5160.5 -8638.0
H2AZ2 -1249.0 -3740.5 -7449.0
H2BC11 7954.0 7009.5 -4404.0
H2BC12 9025.0 8965.5 -7638.0
H2BC15 5393.0 5254.5 -4378.0
H2BC17 7392.0 6731.5 -2437.0
H2BC21 9211.0 9169.5 -2181.0
H2BC4 7438.0 8876.5 -575.0
H2BC5 8040.0 7278.5 -4891.0
H2BC9 5396.0 -3277.5 -2834.0
H2BU1 -6302.0 -1745.5 -1518.0
H3-3A 8612.0 9279.5 1082.0
H3C15 6686.5 6812.0 -5402.5
KDM1A -9158.0 -7472.5 -5321.0
KDM4C -10177.0 -5408.5 -1116.0
KLK2 3056.0 5364.5 10131.0
MYH10 658.0 6149.5 5118.0
MYH11 -3387.0 -3208.5 5759.0
MYH9 6678.0 8971.5 -4854.0
MYL12B 5119.0 6824.5 -2978.0
MYL6 8547.0 10014.5 -8390.0
MYL9 7605.0 5473.5 4521.0
NCOA2 1100.0 6393.5 5350.0
PAK1 8124.0 9588.5 9318.0
PDPK1 6122.0 8512.5 -3397.0
PKN1 -1946.0 7416.5 -6225.0
PKN2 150.0 -1595.5 11721.0
PKN3 -3604.0 187.5 -2940.0
PPP1CB 6990.0 7433.5 9292.0
PPP1R12A 6046.0 8180.5 9594.0
PPP1R12B 1724.0 5119.5 994.0
PPP1R14A 6908.0 297.5 -8992.0
RAC1 8578.0 10538.5 7795.0
RHOA 8091.0 9816.5 4832.0
RHOB 1180.0 7482.5 6800.0
RHOC -10985.0 5823.5 2631.0
SFN 1544.0 797.5 -2570.0
YWHAB 6309.0 7043.5 9812.0
YWHAE 8860.0 9554.5 5531.0
YWHAG 9154.0 10235.5 -3467.0
YWHAH 8484.0 10319.5 4547.0
YWHAQ -7212.0 -3210.5 -2044.0
YWHAZ 5617.0 6696.5 6589.0



InlB-mediated entry of Listeria monocytogenes into host cell

metric value
setSize 12
pMANOVA 0.00843
p.adjustMANOVA 0.0194
s.dist 0.679
s.t0_v_pod 0.524
s.pod_crp 0.386
s.t0_crp -0.193
p.t0_v_pod 0.00166
p.pod_crp 0.0206
p.t0_crp 0.247




Gene t0_v_pod pod_crp
GRB2 9164 10574.5
CBL 7487 9438.5
SH3GL1 7618 8529.5
STAM2 6096 7428.5
SH3KBP1 6140 6877.5
HGS 4524 7671.5
UBC 4378 6962.5
EPS15 4150 6050.5
UBB 6643 1475.5
STAM 1289 1180.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
CBL 7487 9438.5 -3450
EPS15 4150 6050.5 11171
GRB2 9164 10574.5 -1296
HGS 4524 7671.5 361
RPS27A -6658 -9698.5 -9022
SH3GL1 7618 8529.5 -7869
SH3KBP1 6140 6877.5 518
STAM 1289 1180.5 6671
STAM2 6096 7428.5 11573
UBA52 1062 -2813.5 -8649
UBB 6643 1475.5 -6574
UBC 4378 6962.5 946



Smooth Muscle Contraction

metric value
setSize 31
pMANOVA 6.54e-06
p.adjustMANOVA 3.74e-05
s.dist 0.679
s.t0_v_pod 0.493
s.pod_crp 0.447
s.t0_crp -0.137
p.t0_v_pod 2.03e-06
p.pod_crp 1.67e-05
p.t0_crp 0.188




Gene t0_v_pod pod_crp
DYSF 9356 11005.5
ANXA2 8294 10557.5
MYL6B 8191 10504.5
TLN1 8420 10166.5
MYL6 8547 10014.5
TPM4 9091 9311.5
TPM3 7886 10060.5
PAK1 8124 9588.5
PAK2 8099 9157.5
ITGA1 8675 7932.5
PXN 6244 9442.5
ANXA1 7420 7697.5
CALD1 8151 6861.5
TPM1 8019 6586.5
VCL 7273 7218.5
MYL12A 6881 6871.5
MYL9 7605 5473.5
ITGB5 6903 5195.5
MYL12B 5119 6824.5
MYLK 6596 4126.5

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
ACTA2 -426 1323.5 2131
ANXA1 7420 7697.5 -1039
ANXA2 8294 10557.5 5142
ANXA6 248 4498.5 -8155
CALD1 8151 6861.5 1827
CALM1 -2006 776.5 2755
DYSF 9356 11005.5 3350
GUCY1B2 -4938 -4664.5 -2743
ITGA1 8675 7932.5 279
ITGB5 6903 5195.5 -1331
MYH11 -3387 -3208.5 5759
MYL12A 6881 6871.5 -727
MYL12B 5119 6824.5 -2978
MYL5 3227 6106.5 3054
MYL6 8547 10014.5 -8390
MYL6B 8191 10504.5 -1452
MYL9 7605 5473.5 4521
MYLK 6596 4126.5 3200
MYLPF -8549 -6725.5 -5913
PAK1 8124 9588.5 9318
PAK2 8099 9157.5 7107
PXN 6244 9442.5 -6596
SORBS1 1614 8809.5 1397
SORBS3 -10592 -10275.5 -8017
TLN1 8420 10166.5 -4313
TPM1 8019 6586.5 -2065
TPM2 -8607 -8358.5 -6742
TPM3 7886 10060.5 7436
TPM4 9091 9311.5 -1371
TRIM72 1982 5783.5 10112
VCL 7273 7218.5 -1287



ERKs are inactivated

metric value
setSize 13
pMANOVA 0.00387
p.adjustMANOVA 0.00998
s.dist 0.675
s.t0_v_pod 0.43
s.pod_crp 0.443
s.t0_crp -0.274
p.t0_v_pod 0.00727
p.pod_crp 0.00569
p.t0_crp 0.0869




Gene pod_crp t0_v_pod
MAPK1 10809.5 7410
MAPK3 8957.5 8928
DUSP3 8018.5 9168
PPP2CA 7755.5 8179
PPP2CB 8182.5 7654
PPP2R1A 5445.5 4621
PPP2R5D 6108.5 2423
VRK3 6568.5 1283

Click HERE to show all gene set members

t0_v_pod pod_crp t0_crp
DUSP3 9168 8018.5 -2619
DUSP4 -6219 -1033.5 1834
DUSP6 4324 -1915.5 3059
DUSP7 -3165 -1980.5 -5959
MAPK1 7410 10809.5 652
MAPK3 8928 8957.5 -9052
MAPK7 -1276 9218.5 -1240
PPP2CA 8179 7755.5 459
PPP2CB 7654 8182.5 4467
PPP2R1A 4621 5445.5 -8081
PPP2R1B -246 -79.5 4856
PPP2R5D 2423 6108.5 -4168
VRK3 1283 6568.5 -1553



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.4                
##  [7] MASS_7.3-51.6               fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.1               rstudioapi_0.11       
##  [7] farver_2.0.3           bit64_0.9-7            AnnotationDbi_1.50.0  
## [10] fansi_0.4.1            lubridate_1.7.9        xml2_1.3.2            
## [13] splines_4.0.2          geneplotter_1.66.0     knitr_1.28            
## [16] jsonlite_1.6.1         broom_0.5.6            annotate_1.66.0       
## [19] dbplyr_1.4.4           shiny_1.4.0.2          compiler_4.0.2        
## [22] httr_1.4.1             backports_1.1.8        fastmap_1.0.1         
## [25] assertthat_0.2.1       Matrix_1.2-18          cli_2.0.2             
## [28] later_1.1.0.1          htmltools_0.5.0        tools_4.0.2           
## [31] gtable_0.3.0           glue_1.4.1             GenomeInfoDbData_1.2.3
## [34] fastmatch_1.1-0        Rcpp_1.0.4.6           cellranger_1.1.0      
## [37] vctrs_0.3.1            gdata_2.18.0           nlme_3.1-148          
## [40] xfun_0.15              testthat_2.3.2         rvest_0.3.5           
## [43] mime_0.9               lifecycle_0.2.0        XML_3.99-0.3          
## [46] zlibbioc_1.34.0        scales_1.1.1           promises_1.1.1        
## [49] hms_0.5.3              RColorBrewer_1.1-2     yaml_2.2.1            
## [52] memoise_1.1.0          gridExtra_2.3          reshape_0.8.8         
## [55] stringi_1.4.6          RSQLite_2.2.0          highr_0.8             
## [58] genefilter_1.70.0      desc_1.2.0             caTools_1.18.0        
## [61] BiocParallel_1.22.0    rlang_0.4.6            pkgconfig_2.0.3       
## [64] bitops_1.0-6           evaluate_0.14          lattice_0.20-41       
## [67] labeling_0.3           htmlwidgets_1.5.1      bit_1.1-15.2          
## [70] tidyselect_1.1.0       plyr_1.8.6             magrittr_1.5          
## [73] R6_2.4.1               generics_0.0.2         DBI_1.1.0             
## [76] pillar_1.4.4           haven_2.3.1            withr_2.2.0           
## [79] survival_3.2-3         RCurl_1.98-1.2         modelr_0.1.8          
## [82] crayon_1.3.4           KernSmooth_2.23-17     rmarkdown_2.3         
## [85] locfit_1.5-9.4         grid_4.0.2             readxl_1.3.1          
## [88] data.table_1.12.8      blob_1.2.1             reprex_0.3.0          
## [91] digest_0.6.25          pbmcapply_1.5.0        xtable_1.8-4          
## [94] httpuv_1.5.4           munsell_0.5.0

END of report