Mitch Report

date generated: 2020-09-10

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                   x
## A1BG     -0.3065476
## A1BG-AS1  0.2667380
## A1CF     -0.1889397
## A2M      -0.4487032
## A2M-AS1  -0.9062206
## A2ML1     1.1221162

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	2400
num_genes_in_profile	21631
duplicated_genes_present	0
num_profile_genes_in_sets	8419
num_profile_genes_not_in_sets	13212

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	2400
num_genesets_excluded	1039
num_genesets_included	1361

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 100 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
IRAK4 deficiency (TLR2/4)	10	2.19e-06	0.864	3.11e-05
MyD88 deficiency (TLR2/4)	10	2.19e-06	0.864	3.11e-05
Peptide chain elongation	88	5.06e-36	-0.771	6.88e-34
Eukaryotic Translation Elongation	93	1.44e-37	-0.767	2.18e-35
Selenocysteine synthesis	92	1.36e-35	-0.750	1.68e-33
Viral mRNA Translation	88	6.76e-34	-0.747	6.14e-32
Formation of a pool of free 40S subunits	100	4.05e-38	-0.746	6.88e-36
Eukaryotic Translation Termination	92	3.30e-34	-0.734	3.21e-32
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.52e-05	0.721	1.79e-04
alpha-linolenic acid (ALA) metabolism	12	1.52e-05	0.721	1.79e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	1.58e-32	-0.708	1.20e-30
Translocation of ZAP-70 to Immunological synapse	24	1.98e-09	-0.707	5.09e-08
L13a-mediated translational silencing of Ceruloplasmin expression	110	7.55e-35	-0.678	8.56e-33
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.11e-34	-0.674	1.16e-32
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	3.17e-31	-0.672	2.27e-29
Formation of the ternary complex, and subsequently, the 43S complex	51	1.92e-16	-0.665	8.41e-15
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.55e-04	0.659	1.33e-03
Regulation of TLR by endogenous ligand	11	2.34e-04	0.641	1.88e-03
Major pathway of rRNA processing in the nucleolus and cytosol	180	6.06e-50	-0.641	2.06e-47
Cap-dependent Translation Initiation	118	2.65e-33	-0.640	2.12e-31
Eukaryotic Translation Initiation	118	2.65e-33	-0.640	2.12e-31
rRNA processing in the nucleus and cytosol	190	7.19e-52	-0.636	4.89e-49
Selenoamino acid metabolism	114	2.44e-30	-0.620	1.58e-28
RHO GTPases Activate ROCKs	18	6.30e-06	0.615	8.41e-05
Uptake and function of anthrax toxins	10	8.17e-04	0.611	4.92e-03
Activation of the pre-replicative complex	32	2.71e-09	-0.607	6.59e-08
MET activates RAP1 and RAC1	10	1.02e-03	0.600	5.89e-03
rRNA processing	217	2.08e-51	-0.593	9.44e-49
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.63e-27	-0.588	9.23e-26
Nonsense-Mediated Decay (NMD)	114	1.63e-27	-0.588	9.23e-26
rRNA modification in the nucleus and cytosol	59	5.93e-15	-0.587	2.45e-13
SRP-dependent cotranslational protein targeting to membrane	111	1.23e-26	-0.586	6.19e-25
Translation initiation complex formation	58	1.23e-14	-0.585	4.80e-13
Nucleobase biosynthesis	13	2.88e-04	-0.581	2.22e-03
Influenza Viral RNA Transcription and Replication	135	5.44e-31	-0.576	3.70e-29
Ribosomal scanning and start codon recognition	58	3.26e-14	-0.576	1.20e-12
Hyaluronan uptake and degradation	12	5.72e-04	0.574	3.74e-03
Unwinding of DNA	12	5.97e-04	-0.572	3.87e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	2.93e-14	-0.572	1.11e-12
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	1.74e-03	0.572	8.87e-03
VLDLR internalisation and degradation	12	6.42e-04	0.569	4.06e-03
PD-1 signaling	28	2.24e-07	-0.565	4.12e-06
Platelet sensitization by LDL	16	1.04e-04	0.560	9.47e-04
DNA strand elongation	32	4.60e-08	-0.558	1.01e-06
Processive synthesis on the lagging strand	15	2.00e-04	-0.555	1.67e-03
Lagging Strand Synthesis	20	2.12e-05	-0.549	2.41e-04
Gap junction trafficking	13	6.40e-04	0.547	4.06e-03
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.79e-03	0.544	9.07e-03
RHO GTPases Activate WASPs and WAVEs	35	3.78e-08	0.537	8.44e-07
Advanced glycosylation endproduct receptor signaling	12	1.28e-03	0.537	7.01e-03
PCNA-Dependent Long Patch Base Excision Repair	21	2.52e-05	-0.531	2.77e-04
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	9.51e-04	0.529	5.58e-03
Removal of the Flap Intermediate	14	6.35e-04	-0.527	4.06e-03
Erythrocytes take up carbon dioxide and release oxygen	12	1.58e-03	0.527	8.15e-03
O2/CO2 exchange in erythrocytes	12	1.58e-03	0.527	8.15e-03
SLBP independent Processing of Histone Pre-mRNAs	10	4.33e-03	-0.521	1.78e-02
WNT5A-dependent internalization of FZD4	13	1.18e-03	0.519	6.60e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	1.17e-05	-0.517	1.47e-04
Retrograde neurotrophin signalling	12	2.17e-03	0.511	1.06e-02
Prolonged ERK activation events	13	1.51e-03	0.508	7.99e-03
Purine ribonucleoside monophosphate biosynthesis	10	5.45e-03	-0.507	2.19e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	3.87e-03	-0.503	1.64e-02
Influenza Infection	154	4.36e-27	-0.503	2.28e-25
Signal transduction by L1	20	1.05e-04	0.501	9.53e-04
Erythropoietin activates RAS	13	1.81e-03	0.500	9.12e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	8.51e-04	0.497	5.08e-03
Activation of ATR in response to replication stress	37	2.01e-07	-0.494	3.75e-06
Telomere C-strand (Lagging Strand) Synthesis	34	6.34e-07	-0.493	1.04e-05
Phosphorylation of CD3 and TCR zeta chains	27	1.07e-05	-0.489	1.38e-04
RHO GTPases activate CIT	18	3.25e-04	0.489	2.45e-03
Generation of second messenger molecules	38	2.64e-07	-0.482	4.67e-06
Pre-NOTCH Processing in Golgi	18	4.08e-04	0.481	2.89e-03
Heme degradation	10	8.89e-03	0.478	3.20e-02
BBSome-mediated cargo-targeting to cilium	22	1.14e-04	-0.475	1.02e-03
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.08e-03	0.475	1.03e-02
Diseases associated with the TLR signaling cascade	23	7.99e-05	0.475	7.55e-04
Diseases of Immune System	23	7.99e-05	0.475	7.55e-04
RHO GTPases activate IQGAPs	11	6.80e-03	0.471	2.58e-02
EPHB-mediated forward signaling	32	4.14e-06	0.470	5.69e-05
RHO GTPases Activate NADPH Oxidases	21	2.04e-04	0.468	1.68e-03
Telomere C-strand synthesis initiation	13	3.50e-03	-0.468	1.51e-02
Sema4D in semaphorin signaling	22	1.52e-04	0.466	1.32e-03
COPI-independent Golgi-to-ER retrograde traffic	33	5.41e-06	0.457	7.29e-05
Cargo concentration in the ER	30	1.48e-05	0.457	1.79e-04
Sema4D induced cell migration and growth-cone collapse	19	5.82e-04	0.456	3.79e-03
Leading Strand Synthesis	14	3.29e-03	-0.454	1.45e-02
Polymerase switching	14	3.29e-03	-0.454	1.45e-02
Signaling by Erythropoietin	24	1.26e-04	0.452	1.13e-03
GPVI-mediated activation cascade	31	1.49e-05	0.449	1.79e-04
Neutrophil degranulation	458	3.16e-61	0.449	4.30e-58
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.02e-02	0.447	3.63e-02
RHO GTPases activate PAKs	20	5.38e-04	0.447	3.59e-03
Hyaluronan metabolism	15	2.74e-03	0.447	1.24e-02
Translation	295	9.42e-40	-0.446	2.14e-37
Frs2-mediated activation	11	1.05e-02	0.445	3.69e-02
Regulated proteolysis of p75NTR	11	1.09e-02	0.443	3.78e-02
Translesion synthesis by REV1	16	2.21e-03	-0.442	1.07e-02
Trafficking of GluR2-containing AMPA receptors	12	8.28e-03	0.440	3.01e-02
AKT phosphorylates targets in the cytosol	14	4.65e-03	0.437	1.89e-02
Mucopolysaccharidoses	11	1.22e-02	0.437	4.12e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
IRAK4 deficiency (TLR2/4)	10	2.19e-06	0.864000	3.11e-05
MyD88 deficiency (TLR2/4)	10	2.19e-06	0.864000	3.11e-05
Peptide chain elongation	88	5.06e-36	-0.771000	6.88e-34
Eukaryotic Translation Elongation	93	1.44e-37	-0.767000	2.18e-35
Selenocysteine synthesis	92	1.36e-35	-0.750000	1.68e-33
Viral mRNA Translation	88	6.76e-34	-0.747000	6.14e-32
Formation of a pool of free 40S subunits	100	4.05e-38	-0.746000	6.88e-36
Eukaryotic Translation Termination	92	3.30e-34	-0.734000	3.21e-32
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	12	1.52e-05	0.721000	1.79e-04
alpha-linolenic acid (ALA) metabolism	12	1.52e-05	0.721000	1.79e-04
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	94	1.58e-32	-0.708000	1.20e-30
Translocation of ZAP-70 to Immunological synapse	24	1.98e-09	-0.707000	5.09e-08
L13a-mediated translational silencing of Ceruloplasmin expression	110	7.55e-35	-0.678000	8.56e-33
GTP hydrolysis and joining of the 60S ribosomal subunit	111	1.11e-34	-0.674000	1.16e-32
Response of EIF2AK4 (GCN2) to amino acid deficiency	100	3.17e-31	-0.672000	2.27e-29
Formation of the ternary complex, and subsequently, the 43S complex	51	1.92e-16	-0.665000	8.41e-15
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	11	1.55e-04	0.659000	1.33e-03
Regulation of TLR by endogenous ligand	11	2.34e-04	0.641000	1.88e-03
Major pathway of rRNA processing in the nucleolus and cytosol	180	6.06e-50	-0.641000	2.06e-47
Cap-dependent Translation Initiation	118	2.65e-33	-0.640000	2.12e-31
Eukaryotic Translation Initiation	118	2.65e-33	-0.640000	2.12e-31
rRNA processing in the nucleus and cytosol	190	7.19e-52	-0.636000	4.89e-49
Selenoamino acid metabolism	114	2.44e-30	-0.620000	1.58e-28
RHO GTPases Activate ROCKs	18	6.30e-06	0.615000	8.41e-05
Uptake and function of anthrax toxins	10	8.17e-04	0.611000	4.92e-03
Activation of the pre-replicative complex	32	2.71e-09	-0.607000	6.59e-08
MET activates RAP1 and RAC1	10	1.02e-03	0.600000	5.89e-03
rRNA processing	217	2.08e-51	-0.593000	9.44e-49
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	114	1.63e-27	-0.588000	9.23e-26
Nonsense-Mediated Decay (NMD)	114	1.63e-27	-0.588000	9.23e-26
rRNA modification in the nucleus and cytosol	59	5.93e-15	-0.587000	2.45e-13
SRP-dependent cotranslational protein targeting to membrane	111	1.23e-26	-0.586000	6.19e-25
Translation initiation complex formation	58	1.23e-14	-0.585000	4.80e-13
Nucleobase biosynthesis	13	2.88e-04	-0.581000	2.22e-03
Influenza Viral RNA Transcription and Replication	135	5.44e-31	-0.576000	3.70e-29
Ribosomal scanning and start codon recognition	58	3.26e-14	-0.576000	1.20e-12
Hyaluronan uptake and degradation	12	5.72e-04	0.574000	3.74e-03
Unwinding of DNA	12	5.97e-04	-0.572000	3.87e-03
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	59	2.93e-14	-0.572000	1.11e-12
NOTCH4 Activation and Transmission of Signal to the Nucleus	10	1.74e-03	0.572000	8.87e-03
VLDLR internalisation and degradation	12	6.42e-04	0.569000	4.06e-03
PD-1 signaling	28	2.24e-07	-0.565000	4.12e-06
Platelet sensitization by LDL	16	1.04e-04	0.560000	9.47e-04
DNA strand elongation	32	4.60e-08	-0.558000	1.01e-06
Processive synthesis on the lagging strand	15	2.00e-04	-0.555000	1.67e-03
Lagging Strand Synthesis	20	2.12e-05	-0.549000	2.41e-04
Gap junction trafficking	13	6.40e-04	0.547000	4.06e-03
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	11	1.79e-03	0.544000	9.07e-03
RHO GTPases Activate WASPs and WAVEs	35	3.78e-08	0.537000	8.44e-07
Advanced glycosylation endproduct receptor signaling	12	1.28e-03	0.537000	7.01e-03
PCNA-Dependent Long Patch Base Excision Repair	21	2.52e-05	-0.531000	2.77e-04
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	13	9.51e-04	0.529000	5.58e-03
Removal of the Flap Intermediate	14	6.35e-04	-0.527000	4.06e-03
Erythrocytes take up carbon dioxide and release oxygen	12	1.58e-03	0.527000	8.15e-03
O2/CO2 exchange in erythrocytes	12	1.58e-03	0.527000	8.15e-03
SLBP independent Processing of Histone Pre-mRNAs	10	4.33e-03	-0.521000	1.78e-02
WNT5A-dependent internalization of FZD4	13	1.18e-03	0.519000	6.60e-03
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	24	1.17e-05	-0.517000	1.47e-04
Retrograde neurotrophin signalling	12	2.17e-03	0.511000	1.06e-02
Prolonged ERK activation events	13	1.51e-03	0.508000	7.99e-03
Purine ribonucleoside monophosphate biosynthesis	10	5.45e-03	-0.507000	2.19e-02
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11	3.87e-03	-0.503000	1.64e-02
Influenza Infection	154	4.36e-27	-0.503000	2.28e-25
Signal transduction by L1	20	1.05e-04	0.501000	9.53e-04
Erythropoietin activates RAS	13	1.81e-03	0.500000	9.12e-03
Synthesis of Leukotrienes (LT) and Eoxins (EX)	15	8.51e-04	0.497000	5.08e-03
Activation of ATR in response to replication stress	37	2.01e-07	-0.494000	3.75e-06
Telomere C-strand (Lagging Strand) Synthesis	34	6.34e-07	-0.493000	1.04e-05
Phosphorylation of CD3 and TCR zeta chains	27	1.07e-05	-0.489000	1.38e-04
RHO GTPases activate CIT	18	3.25e-04	0.489000	2.45e-03
Generation of second messenger molecules	38	2.64e-07	-0.482000	4.67e-06
Pre-NOTCH Processing in Golgi	18	4.08e-04	0.481000	2.89e-03
Heme degradation	10	8.89e-03	0.478000	3.20e-02
BBSome-mediated cargo-targeting to cilium	22	1.14e-04	-0.475000	1.02e-03
Golgi Cisternae Pericentriolar Stack Reorganization	14	2.08e-03	0.475000	1.03e-02
Diseases associated with the TLR signaling cascade	23	7.99e-05	0.475000	7.55e-04
Diseases of Immune System	23	7.99e-05	0.475000	7.55e-04
RHO GTPases activate IQGAPs	11	6.80e-03	0.471000	2.58e-02
EPHB-mediated forward signaling	32	4.14e-06	0.470000	5.69e-05
RHO GTPases Activate NADPH Oxidases	21	2.04e-04	0.468000	1.68e-03
Telomere C-strand synthesis initiation	13	3.50e-03	-0.468000	1.51e-02
Sema4D in semaphorin signaling	22	1.52e-04	0.466000	1.32e-03
COPI-independent Golgi-to-ER retrograde traffic	33	5.41e-06	0.457000	7.29e-05
Cargo concentration in the ER	30	1.48e-05	0.457000	1.79e-04
Sema4D induced cell migration and growth-cone collapse	19	5.82e-04	0.456000	3.79e-03
Leading Strand Synthesis	14	3.29e-03	-0.454000	1.45e-02
Polymerase switching	14	3.29e-03	-0.454000	1.45e-02
Signaling by Erythropoietin	24	1.26e-04	0.452000	1.13e-03
GPVI-mediated activation cascade	31	1.49e-05	0.449000	1.79e-04
Neutrophil degranulation	458	3.16e-61	0.449000	4.30e-58
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	11	1.02e-02	0.447000	3.63e-02
RHO GTPases activate PAKs	20	5.38e-04	0.447000	3.59e-03
Hyaluronan metabolism	15	2.74e-03	0.447000	1.24e-02
Translation	295	9.42e-40	-0.446000	2.14e-37
Frs2-mediated activation	11	1.05e-02	0.445000	3.69e-02
Regulated proteolysis of p75NTR	11	1.09e-02	0.443000	3.78e-02
Translesion synthesis by REV1	16	2.21e-03	-0.442000	1.07e-02
Trafficking of GluR2-containing AMPA receptors	12	8.28e-03	0.440000	3.01e-02
AKT phosphorylates targets in the cytosol	14	4.65e-03	0.437000	1.89e-02
Mucopolysaccharidoses	11	1.22e-02	0.437000	4.12e-02
Detoxification of Reactive Oxygen Species	32	2.51e-05	0.430000	2.77e-04
Metabolism of non-coding RNA	53	6.30e-08	-0.429000	1.30e-06
snRNP Assembly	53	6.30e-08	-0.429000	1.30e-06
RHO GTPases activate PKNs	48	3.53e-07	0.425000	6.00e-06
Gap junction trafficking and regulation	15	4.41e-03	0.425000	1.81e-02
Regulation of IFNG signaling	14	6.27e-03	0.422000	2.43e-02
Recycling pathway of L1	26	2.57e-04	0.414000	2.03e-03
Translesion synthesis by POLI	17	3.35e-03	-0.411000	1.47e-02
Negative regulation of MET activity	18	2.58e-03	0.410000	1.18e-02
Polymerase switching on the C-strand of the telomere	26	2.94e-04	-0.410000	2.25e-03
RNA Polymerase I Promoter Opening	19	2.22e-03	0.405000	1.07e-02
Dissolution of Fibrin Clot	12	1.51e-02	0.405000	4.93e-02
ERKs are inactivated	13	1.17e-02	0.404000	4.00e-02
Regulation of signaling by CBL	18	3.09e-03	0.403000	1.38e-02
tRNA modification in the nucleus and cytosol	43	5.03e-06	-0.402000	6.85e-05
Insulin receptor recycling	21	1.49e-03	0.400000	7.93e-03
MAP2K and MAPK activation	34	5.66e-05	0.399000	5.54e-04
Extension of Telomeres	51	9.09e-07	-0.397000	1.44e-05
IRAK1 recruits IKK complex	10	3.02e-02	0.396000	8.52e-02
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	10	3.02e-02	0.396000	8.52e-02
Integrin signaling	22	1.34e-03	0.395000	7.29e-03
RORA activates gene expression	18	3.76e-03	0.394000	1.61e-02
Interactions of Vpr with host cellular proteins	37	3.43e-05	-0.394000	3.70e-04
Resolution of Abasic Sites (AP sites)	37	4.22e-05	-0.389000	4.35e-04
Translesion synthesis by POLK	17	5.73e-03	-0.387000	2.26e-02
VxPx cargo-targeting to cilium	19	3.50e-03	0.387000	1.51e-02
Signaling by high-kinase activity BRAF mutants	31	2.02e-04	0.386000	1.68e-03
Rev-mediated nuclear export of HIV RNA	35	7.89e-05	-0.386000	7.55e-04
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14	1.27e-02	-0.385000	4.25e-02
mRNA decay by 3' to 5' exoribonuclease	16	7.70e-03	-0.385000	2.86e-02
Regulation of expression of SLITs and ROBOs	159	6.82e-17	-0.383000	3.09e-15
Signaling by Leptin	10	3.66e-02	0.382000	9.82e-02
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	21	2.48e-03	0.381000	1.15e-02
Neurodegenerative Diseases	21	2.48e-03	0.381000	1.15e-02
Chondroitin sulfate biosynthesis	12	2.22e-02	0.381000	6.68e-02
G-protein beta:gamma signalling	29	3.86e-04	0.381000	2.79e-03
Processive synthesis on the C-strand of the telomere	19	4.06e-03	-0.381000	1.70e-02
Gap-filling DNA repair synthesis and ligation in GG-NER	25	9.91e-04	-0.380000	5.79e-03
Interactions of Rev with host cellular proteins	37	6.52e-05	-0.379000	6.34e-04
Collagen degradation	29	4.12e-04	0.379000	2.90e-03
tRNA Aminoacylation	42	2.27e-05	-0.378000	2.56e-04
Postmitotic nuclear pore complex (NPC) reformation	27	6.85e-04	-0.377000	4.22e-03
Mitochondrial tRNA aminoacylation	21	2.83e-03	-0.376000	1.27e-02
Sealing of the nuclear envelope (NE) by ESCRT-III	25	1.13e-03	0.376000	6.37e-03
p130Cas linkage to MAPK signaling for integrins	11	3.09e-02	0.376000	8.65e-02
Endosomal Sorting Complex Required For Transport (ESCRT)	29	4.77e-04	0.375000	3.25e-03
Vpr-mediated nuclear import of PICs	34	1.62e-04	-0.374000	1.38e-03
Glycogen breakdown (glycogenolysis)	13	1.99e-02	0.373000	6.13e-02
Mitochondrial translation elongation	91	8.68e-10	-0.372000	2.32e-08
Pentose phosphate pathway	13	2.07e-02	0.370000	6.30e-02
tRNA processing in the nucleus	59	9.95e-07	-0.368000	1.56e-05
Budding and maturation of HIV virion	26	1.18e-03	0.367000	6.60e-03
ROS and RNS production in phagocytes	31	4.06e-04	0.367000	2.89e-03
Spry regulation of FGF signaling	16	1.13e-02	0.366000	3.90e-02
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	22	2.99e-03	0.366000	1.34e-02
Transferrin endocytosis and recycling	26	1.25e-03	0.365000	6.94e-03
HDMs demethylate histones	22	3.02e-03	0.365000	1.35e-02
EPH-Ephrin signaling	79	2.09e-08	0.365000	4.82e-07
COPI-mediated anterograde transport	78	2.88e-08	0.363000	6.53e-07
Beta-catenin phosphorylation cascade	17	9.56e-03	0.363000	3.43e-02
Smooth Muscle Contraction	31	4.74e-04	0.363000	3.25e-03
Early Phase of HIV Life Cycle	14	1.88e-02	-0.363000	5.84e-02
Signaling by RAF1 mutants	34	2.62e-04	0.362000	2.05e-03
Interleukin-3, Interleukin-5 and GM-CSF signaling	40	8.08e-05	0.360000	7.58e-04
Diseases of DNA repair	10	4.87e-02	-0.360000	1.21e-01
Folding of actin by CCT/TriC	10	4.90e-02	-0.360000	1.22e-01
Cytosolic tRNA aminoacylation	24	2.30e-03	-0.359000	1.09e-02
Mitochondrial translation termination	91	3.55e-09	-0.358000	8.47e-08
Recognition of DNA damage by PCNA-containing replication complex	30	6.95e-04	-0.358000	4.24e-03
Mitochondrial translation initiation	91	3.68e-09	-0.358000	8.63e-08
NEP/NS2 Interacts with the Cellular Export Machinery	32	4.77e-04	-0.357000	3.25e-03
Metabolism of amine-derived hormones	10	5.10e-02	-0.356000	1.26e-01
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14	2.13e-02	-0.355000	6.43e-02
Growth hormone receptor signaling	20	5.93e-03	0.355000	2.32e-02
InlB-mediated entry of Listeria monocytogenes into host cell	12	3.35e-02	0.354000	9.15e-02
Mismatch Repair	15	1.78e-02	-0.353000	5.60e-02
Intraflagellar transport	39	1.35e-04	-0.353000	1.19e-03
Nuclear import of Rev protein	34	3.66e-04	-0.353000	2.72e-03
FOXO-mediated transcription of cell death genes	16	1.50e-02	0.351000	4.91e-02
COPII-mediated vesicle transport	65	1.07e-06	0.350000	1.66e-05
Mitochondrial translation	97	2.66e-09	-0.350000	6.59e-08
BMAL1:CLOCK,NPAS2 activates circadian gene expression	25	2.61e-03	0.348000	1.19e-02
RNA Polymerase I Transcription Initiation	47	3.98e-05	-0.346000	4.14e-04
Interleukin-6 signaling	10	5.85e-02	0.346000	1.38e-01
ER to Golgi Anterograde Transport	129	1.91e-11	0.342000	6.05e-10
Post-translational protein phosphorylation	70	7.43e-07	0.342000	1.19e-05
Regulation of IFNA signaling	12	4.03e-02	0.342000	1.07e-01
tRNA processing	134	8.34e-12	-0.342000	2.83e-10
Regulation of cholesterol biosynthesis by SREBP (SREBF)	55	1.17e-05	0.342000	1.47e-04
RNA Polymerase I Transcription Termination	30	1.23e-03	-0.341000	6.81e-03
Notch-HLH transcription pathway	28	1.79e-03	0.341000	9.07e-03
Platelet Aggregation (Plug Formation)	28	1.83e-03	0.340000	9.18e-03
activated TAK1 mediates p38 MAPK activation	19	1.03e-02	0.340000	3.65e-02
Signal regulatory protein family interactions	12	4.17e-02	0.340000	1.10e-01
Beta-oxidation of very long chain fatty acids	10	6.34e-02	0.339000	1.46e-01
Removal of the Flap Intermediate from the C-strand	17	1.56e-02	-0.339000	5.03e-02
LDL clearance	18	1.31e-02	0.338000	4.36e-02
Termination of translesion DNA synthesis	32	1.09e-03	-0.334000	6.22e-03
Adenylate cyclase inhibitory pathway	11	5.99e-02	0.328000	1.41e-01
EPHA-mediated growth cone collapse	13	4.09e-02	0.327000	1.08e-01
HDR through MMEJ (alt-NHEJ)	10	7.32e-02	-0.327000	1.63e-01
ADP signalling through P2Y purinoceptor 1	21	9.78e-03	0.326000	3.49e-02
G beta:gamma signalling through PI3Kgamma	22	8.21e-03	0.326000	3.00e-02
Pyrimidine salvage	10	7.49e-02	0.325000	1.66e-01
trans-Golgi Network Vesicle Budding	69	3.01e-06	0.325000	4.22e-05
Activation of gene expression by SREBF (SREBP)	42	2.86e-04	0.323000	2.21e-03
Export of Viral Ribonucleoproteins from Nucleus	33	1.39e-03	-0.322000	7.46e-03
RNA Polymerase III Chain Elongation	18	1.82e-02	-0.322000	5.69e-02
TBC/RABGAPs	45	1.90e-04	0.322000	1.59e-03
GRB2:SOS provides linkage to MAPK signaling for Integrins	12	5.56e-02	0.319000	1.33e-01
Energy dependent regulation of mTOR by LKB1-AMPK	27	4.14e-03	0.319000	1.72e-02
Paradoxical activation of RAF signaling by kinase inactive BRAF	38	6.83e-04	0.318000	4.22e-03
Signaling by RAS mutants	38	6.83e-04	0.318000	4.22e-03
Signaling by moderate kinase activity BRAF mutants	38	6.83e-04	0.318000	4.22e-03
Signaling downstream of RAS mutants	38	6.83e-04	0.318000	4.22e-03
DNA methylation	20	1.37e-02	0.318000	4.53e-02
RAF activation	32	1.97e-03	0.316000	9.83e-03
RAB GEFs exchange GTP for GDP on RABs	88	3.07e-07	0.316000	5.28e-06
Pre-NOTCH Expression and Processing	65	1.10e-05	0.315000	1.41e-04
Clathrin-mediated endocytosis	127	8.71e-10	0.315000	2.32e-08
Transport of the SLBP Dependant Mature mRNA	36	1.09e-03	-0.315000	6.22e-03
Transport of the SLBP independent Mature mRNA	35	1.28e-03	-0.314000	7.01e-03
Signal amplification	28	4.16e-03	0.313000	1.72e-02
Gastrin-CREB signalling pathway via PKC and MAPK	14	4.34e-02	0.312000	1.13e-01
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS)	12	6.18e-02	0.311000	1.43e-01
Diseases of hemostasis	12	6.18e-02	0.311000	1.43e-01
Transport of Ribonucleoproteins into the Host Nucleus	32	2.36e-03	-0.311000	1.11e-02
Lysosome Vesicle Biogenesis	32	2.44e-03	0.310000	1.14e-02
Synthesis of PC	24	8.72e-03	0.309000	3.15e-02
Pre-NOTCH Transcription and Translation	49	1.82e-04	0.309000	1.55e-03
PPARA activates gene expression	104	5.50e-08	0.308000	1.17e-06
Signalling to ERKs	32	2.54e-03	0.308000	1.17e-02
Thrombin signalling through proteinase activated receptors (PARs)	27	5.61e-03	0.308000	2.23e-02
PKA activation in glucagon signalling	14	4.67e-02	0.307000	1.18e-01
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28	4.96e-03	-0.307000	2.00e-02
Diseases of programmed cell death	23	1.09e-02	0.307000	3.78e-02
RHO GTPases activate KTN1	11	7.89e-02	0.306000	1.72e-01
RAB geranylgeranylation	60	4.39e-05	0.305000	4.46e-04
Dual Incision in GG-NER	41	8.66e-04	-0.301000	5.14e-03
Mitochondrial protein import	64	3.50e-05	-0.299000	3.75e-04
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	81	3.26e-06	0.299000	4.53e-05
CD22 mediated BCR regulation	59	7.14e-05	-0.299000	6.89e-04
Common Pathway of Fibrin Clot Formation	14	5.37e-02	0.298000	1.30e-01
Regulation of lipid metabolism by PPARalpha	106	1.33e-07	0.296000	2.56e-06
GAB1 signalosome	15	4.79e-02	0.295000	1.19e-01
Metabolism of RNA	685	1.65e-39	-0.294000	3.21e-37
Fanconi Anemia Pathway	36	2.26e-03	-0.294000	1.08e-02
MET activates RAS signaling	10	1.08e-01	0.294000	2.15e-01
G beta:gamma signalling through CDC42	17	3.62e-02	0.293000	9.75e-02
GABA receptor activation	35	2.73e-03	0.293000	1.24e-02
Golgi Associated Vesicle Biogenesis	55	1.83e-04	0.292000	1.55e-03
Transport to the Golgi and subsequent modification	155	3.74e-10	0.291000	1.16e-08
Glycosphingolipid metabolism	36	2.50e-03	0.291000	1.15e-02
NS1 Mediated Effects on Host Pathways	40	1.45e-03	-0.291000	7.73e-03
Translesion Synthesis by POLH	18	3.30e-02	-0.290000	9.06e-02
Semaphorin interactions	57	1.53e-04	0.290000	1.32e-03
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	92	1.56e-06	0.290000	2.28e-05
Toll Like Receptor 2 (TLR2) Cascade	92	1.56e-06	0.290000	2.28e-05
Toll Like Receptor TLR1:TLR2 Cascade	92	1.56e-06	0.290000	2.28e-05
Toll Like Receptor TLR6:TLR2 Cascade	92	1.56e-06	0.290000	2.28e-05
Homologous DNA Pairing and Strand Exchange	42	1.16e-03	-0.290000	6.52e-03
Cargo recognition for clathrin-mediated endocytosis	90	2.04e-06	0.290000	2.95e-05
Suppression of phagosomal maturation	12	8.26e-02	0.289000	1.79e-01
Misspliced GSK3beta mutants stabilize beta-catenin	15	5.30e-02	0.289000	1.28e-01
S33 mutants of beta-catenin aren't phosphorylated	15	5.30e-02	0.289000	1.28e-01
S37 mutants of beta-catenin aren't phosphorylated	15	5.30e-02	0.289000	1.28e-01
S45 mutants of beta-catenin aren't phosphorylated	15	5.30e-02	0.289000	1.28e-01
T41 mutants of beta-catenin aren't phosphorylated	15	5.30e-02	0.289000	1.28e-01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	15	5.30e-02	0.289000	1.28e-01
Caspase activation via extrinsic apoptotic signalling pathway	25	1.26e-02	0.288000	4.24e-02
Platelet activation, signaling and aggregation	221	1.64e-13	0.288000	5.86e-12
Activation of GABAB receptors	30	6.39e-03	0.288000	2.46e-02
GABA B receptor activation	30	6.39e-03	0.288000	2.46e-02
Signaling by MET	61	1.02e-04	0.288000	9.39e-04
ATF6 (ATF6-alpha) activates chaperone genes	10	1.15e-01	0.288000	2.24e-01
EGFR downregulation	27	9.76e-03	0.287000	3.49e-02
Rab regulation of trafficking	121	4.86e-08	0.287000	1.05e-06
Dectin-2 family	19	3.03e-02	0.287000	8.53e-02
Biotin transport and metabolism	11	1.02e-01	-0.285000	2.09e-01
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27	1.04e-02	-0.285000	3.68e-02
Post-chaperonin tubulin folding pathway	19	3.18e-02	0.285000	8.79e-02
Apoptosis induced DNA fragmentation	10	1.20e-01	0.284000	2.31e-01
Plasma lipoprotein assembly	10	1.21e-01	0.283000	2.31e-01
Golgi-to-ER retrograde transport	111	2.50e-07	0.283000	4.54e-06
Response to elevated platelet cytosolic Ca2+	110	2.85e-07	0.283000	4.96e-06
Plasma lipoprotein remodeling	18	3.77e-02	0.283000	1.01e-01
SUMOylation of immune response proteins	11	1.05e-01	0.283000	2.13e-01
Presynaptic phase of homologous DNA pairing and strand exchange	39	2.28e-03	-0.282000	1.08e-02
Scavenging by Class A Receptors	11	1.05e-01	0.282000	2.13e-01
Response of Mtb to phagocytosis	22	2.24e-02	0.281000	6.72e-02
SUMOylation of SUMOylation proteins	35	4.04e-03	-0.281000	1.70e-02
Signaling by ROBO receptors	199	8.54e-12	-0.281000	2.83e-10
Late endosomal microautophagy	30	7.81e-03	0.281000	2.87e-02
Transcriptional Regulation by E2F6	34	4.63e-03	-0.281000	1.89e-02
RUNX3 regulates NOTCH signaling	14	6.92e-02	0.281000	1.57e-01
ATF6 (ATF6-alpha) activates chaperones	12	9.25e-02	0.281000	1.95e-01
rRNA processing in the mitochondrion	27	1.17e-02	-0.280000	4.00e-02
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	32	6.07e-03	-0.280000	2.37e-02
Regulation of Glucokinase by Glucokinase Regulatory Protein	32	6.07e-03	-0.280000	2.37e-02
TNFs bind their physiological receptors	25	1.53e-02	-0.280000	4.98e-02
DARPP-32 events	22	2.31e-02	0.280000	6.88e-02
Rap1 signalling	13	8.18e-02	0.279000	1.78e-01
Platelet degranulation	106	7.37e-07	0.278000	1.19e-05
NOTCH3 Intracellular Domain Regulates Transcription	20	3.15e-02	0.278000	8.75e-02
ADP signalling through P2Y purinoceptor 12	18	4.24e-02	0.276000	1.11e-01
G beta:gamma signalling through BTK	15	6.41e-02	0.276000	1.47e-01
L1CAM interactions	85	1.25e-05	0.274000	1.56e-04
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12	1.01e-01	0.273000	2.09e-01
Membrane Trafficking	558	2.21e-28	0.273000	1.37e-26
Degradation of the extracellular matrix	78	3.14e-05	0.273000	3.42e-04
Toll Like Receptor 4 (TLR4) Cascade	121	2.61e-07	0.271000	4.67e-06
Glutamate and glutamine metabolism	12	1.04e-01	-0.271000	2.13e-01
G1/S-Specific Transcription	29	1.20e-02	-0.269000	4.07e-02
Regulation of FZD by ubiquitination	15	7.17e-02	-0.269000	1.60e-01
Assembly of active LPL and LIPC lipase complexes	10	1.43e-01	0.267000	2.64e-01
Signaling by BRAF and RAF fusions	57	4.86e-04	0.267000	3.29e-03
XBP1(S) activates chaperone genes	47	1.53e-03	0.267000	8.06e-03
Transcriptional regulation of granulopoiesis	46	1.73e-03	0.267000	8.87e-03
The NLRP3 inflammasome	15	7.36e-02	0.267000	1.64e-01
SUMOylation of RNA binding proteins	47	1.56e-03	-0.267000	8.14e-03
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	14	8.42e-02	0.267000	1.81e-01
Presynaptic function of Kainate receptors	18	5.03e-02	0.266000	1.25e-01
Transcriptional regulation of white adipocyte differentiation	77	5.40e-05	0.266000	5.33e-04
Amyloid fiber formation	51	1.02e-03	0.266000	5.89e-03
SHC1 events in EGFR signaling	12	1.11e-01	0.265000	2.19e-01
Innate Immune System	967	2.26e-44	0.265000	6.16e-42
Glucagon signaling in metabolic regulation	27	1.72e-02	0.265000	5.46e-02
Antigen processing-Cross presentation	97	6.61e-06	0.265000	8.74e-05
EPH-ephrin mediated repulsion of cells	40	3.78e-03	0.265000	1.61e-02
Translocation of SLC2A4 (GLUT4) to the plasma membrane	48	1.54e-03	0.264000	8.06e-03
Activation of G protein gated Potassium channels	19	4.62e-02	0.264000	1.17e-01
G protein gated Potassium channels	19	4.62e-02	0.264000	1.17e-01
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	19	4.62e-02	0.264000	1.17e-01
Plasma lipoprotein assembly, remodeling, and clearance	53	8.83e-04	0.264000	5.21e-03
NOTCH2 intracellular domain regulates transcription	11	1.33e-01	0.262000	2.48e-01
Signaling by NTRKs	116	1.18e-06	0.261000	1.81e-05
ERK/MAPK targets	22	3.40e-02	0.261000	9.29e-02
Membrane binding and targetting of GAG proteins	13	1.05e-01	0.260000	2.13e-01
Synthesis And Processing Of GAG, GAGPOL Polyproteins	13	1.05e-01	0.260000	2.13e-01
Metabolism of steroid hormones	20	4.50e-02	0.259000	1.16e-01
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	15	8.29e-02	0.259000	1.79e-01
Activated NOTCH1 Transmits Signal to the Nucleus	27	2.00e-02	0.259000	6.14e-02
Signaling by NTRK1 (TRKA)	101	7.13e-06	0.258000	9.33e-05
MET promotes cell motility	26	2.28e-02	0.258000	6.82e-02
Toll-like Receptor Cascades	143	1.03e-07	0.258000	2.05e-06
IRE1alpha activates chaperones	49	1.82e-03	0.257000	9.13e-03
Integration of energy metabolism	86	3.88e-05	0.257000	4.10e-04
NOTCH4 Intracellular Domain Regulates Transcription	17	6.77e-02	0.256000	1.54e-01
G beta:gamma signalling through PLC beta	17	6.83e-02	0.255000	1.55e-01
PINK1-PRKN Mediated Mitophagy	21	4.29e-02	-0.255000	1.12e-01
Glycogen metabolism	23	3.46e-02	0.255000	9.36e-02
Transport of Mature mRNAs Derived from Intronless Transcripts	43	3.88e-03	-0.255000	1.64e-02
Infection with Mycobacterium tuberculosis	26	2.48e-02	0.254000	7.25e-02
VEGFA-VEGFR2 Pathway	92	2.49e-05	0.254000	2.77e-04
Intra-Golgi traffic	43	4.02e-03	0.253000	1.70e-02
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	33	1.17e-02	0.253000	4.00e-02
Transport of Mature mRNA Derived from an Intronless Transcript	42	4.56e-03	-0.253000	1.87e-02
MyD88 dependent cascade initiated on endosome	89	3.92e-05	0.252000	4.10e-04
Toll Like Receptor 7/8 (TLR7/8) Cascade	89	3.92e-05	0.252000	4.10e-04
Defects in vitamin and cofactor metabolism	21	4.55e-02	-0.252000	1.16e-01
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	88	4.58e-05	0.251000	4.62e-04
Long-term potentiation	14	1.04e-01	-0.251000	2.13e-01
Endogenous sterols	17	7.45e-02	0.250000	1.65e-01
AMER1 mutants destabilize the destruction complex	14	1.06e-01	0.250000	2.13e-01
APC truncation mutants have impaired AXIN binding	14	1.06e-01	0.250000	2.13e-01
AXIN missense mutants destabilize the destruction complex	14	1.06e-01	0.250000	2.13e-01
AXIN mutants destabilize the destruction complex, activating WNT signaling	14	1.06e-01	0.250000	2.13e-01
Truncations of AMER1 destabilize the destruction complex	14	1.06e-01	0.250000	2.13e-01
truncated APC mutants destabilize the destruction complex	14	1.06e-01	0.250000	2.13e-01
Transport of Mature mRNA derived from an Intron-Containing Transcript	72	2.57e-04	-0.249000	2.03e-03
Triglyceride catabolism	16	8.46e-02	0.249000	1.82e-01
Plasma lipoprotein clearance	29	2.04e-02	0.249000	6.21e-02
Carboxyterminal post-translational modifications of tubulin	26	2.87e-02	0.248000	8.15e-02
Classical antibody-mediated complement activation	69	3.73e-04	-0.248000	2.74e-03
Oncogenic MAPK signaling	73	2.75e-04	0.246000	2.14e-03
Transcription of E2F targets under negative control by DREAM complex	19	6.32e-02	-0.246000	1.46e-01
Interleukin-27 signaling	11	1.58e-01	0.246000	2.79e-01
Signaling by SCF-KIT	40	7.14e-03	0.246000	2.68e-02
HuR (ELAVL1) binds and stabilizes mRNA	10	1.78e-01	0.246000	3.08e-01
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	16	9.01e-02	0.245000	1.91e-01
Assembly Of The HIV Virion	15	1.01e-01	0.244000	2.09e-01
RNA Polymerase III Transcription Termination	23	4.30e-02	-0.244000	1.12e-01
Interleukin-15 signaling	14	1.15e-01	0.243000	2.24e-01
Activation of Matrix Metalloproteinases	23	4.37e-02	0.243000	1.13e-01
Calnexin/calreticulin cycle	26	3.21e-02	0.243000	8.84e-02
Nuclear Pore Complex (NPC) Disassembly	36	1.18e-02	-0.242000	4.02e-02
Translation of Replicase and Assembly of the Replication Transcription Complex	12	1.47e-01	0.242000	2.69e-01
RUNX3 regulates p14-ARF	10	1.86e-01	0.241000	3.17e-01
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	32	1.81e-02	0.241000	5.68e-02
Thromboxane signalling through TP receptor	20	6.17e-02	0.241000	1.43e-01
Butyrophilin (BTN) family interactions	10	1.86e-01	-0.241000	3.17e-01
Myogenesis	21	5.60e-02	0.241000	1.33e-01
G-protein activation	23	4.60e-02	0.240000	1.17e-01
Interleukin-1 signaling	97	4.38e-05	0.240000	4.46e-04
HDR through Single Strand Annealing (SSA)	37	1.16e-02	-0.240000	3.97e-02
Amino acids regulate mTORC1	50	3.38e-03	0.240000	1.47e-02
Metabolism of porphyrins	22	5.21e-02	0.239000	1.28e-01
Formation of the cornified envelope	21	5.84e-02	0.239000	1.38e-01
Platelet homeostasis	69	6.38e-04	0.238000	4.06e-03
Diseases of carbohydrate metabolism	29	2.70e-02	0.237000	7.77e-02
Scavenging of heme from plasma	71	5.61e-04	-0.237000	3.69e-03
Creation of C4 and C2 activators	71	5.62e-04	-0.237000	3.69e-03
SUMOylation of chromatin organization proteins	57	2.03e-03	-0.236000	1.01e-02
Toll Like Receptor 9 (TLR9) Cascade	93	8.40e-05	0.236000	7.83e-04
Interleukin receptor SHC signaling	23	5.11e-02	0.235000	1.26e-01
Surfactant metabolism	21	6.35e-02	0.234000	1.46e-01
Packaging Of Telomere Ends	20	7.06e-02	0.234000	1.58e-01
Interleukin-10 signaling	34	1.86e-02	0.233000	5.80e-02
FCGR activation	76	4.56e-04	-0.233000	3.17e-03
HDR through Homologous Recombination (HRR)	66	1.12e-03	-0.232000	6.36e-03
IKK complex recruitment mediated by RIP1	23	5.52e-02	0.231000	1.33e-01
MTOR signalling	38	1.39e-02	0.231000	4.58e-02
RIP-mediated NFkB activation via ZBP1	17	9.98e-02	0.231000	2.08e-01
Metabolism of steroids	119	1.42e-05	0.230000	1.76e-04
RET signaling	32	2.46e-02	0.230000	7.23e-02
Cellular response to hypoxia	71	8.35e-04	0.229000	5.01e-03
Disassembly of the destruction complex and recruitment of AXIN to the membrane	29	3.27e-02	0.229000	8.98e-02
Glycogen synthesis	13	1.54e-01	0.228000	2.77e-01
Bile acid and bile salt metabolism	29	3.33e-02	0.228000	9.12e-02
HDACs deacetylate histones	47	6.77e-03	0.228000	2.57e-02
Chromosome Maintenance	105	5.30e-05	-0.228000	5.26e-04
Signaling by NOTCH3	42	1.05e-02	0.228000	3.69e-02
Formation of apoptosome	11	1.90e-01	0.228000	3.20e-01
Regulation of the apoptosome activity	11	1.90e-01	0.228000	3.20e-01
Aquaporin-mediated transport	37	1.64e-02	0.228000	5.25e-02
Signaling by VEGF	100	8.60e-05	0.227000	7.96e-04
Opioid Signalling	75	6.72e-04	0.227000	4.22e-03
Intra-Golgi and retrograde Golgi-to-ER traffic	179	1.62e-07	0.227000	3.06e-06
MyD88 cascade initiated on plasma membrane	82	3.87e-04	0.227000	2.79e-03
Toll Like Receptor 10 (TLR10) Cascade	82	3.87e-04	0.227000	2.79e-03
Toll Like Receptor 5 (TLR5) Cascade	82	3.87e-04	0.227000	2.79e-03
Defects in cobalamin (B12) metabolism	13	1.57e-01	-0.227000	2.79e-01
Cytochrome c-mediated apoptotic response	13	1.58e-01	0.226000	2.79e-01
Negative regulation of FGFR1 signaling	24	5.51e-02	0.226000	1.33e-01
DNA Damage Bypass	47	7.76e-03	-0.224000	2.86e-02
NR1H2 and NR1H3-mediated signaling	39	1.54e-02	0.224000	5.00e-02
Signaling by cytosolic FGFR1 fusion mutants	18	1.01e-01	0.224000	2.09e-01
HSP90 chaperone cycle for steroid hormone receptors (SHR)	36	2.04e-02	0.223000	6.22e-02
Interleukin-1 family signaling	124	1.75e-05	0.223000	2.02e-04
Chemokine receptors bind chemokines	37	1.89e-02	-0.223000	5.86e-02
Retinoid metabolism and transport	24	5.91e-02	0.223000	1.39e-01
Sphingolipid metabolism	77	7.38e-04	0.222000	4.49e-03
Nucleotide salvage	21	7.88e-02	0.222000	1.72e-01
Constitutive Signaling by AKT1 E17K in Cancer	25	5.55e-02	0.221000	1.33e-01
Gluconeogenesis	28	4.27e-02	0.221000	1.11e-01
ER-Phagosome pathway	82	5.52e-04	0.221000	3.66e-03
Asparagine N-linked glycosylation	269	4.67e-10	0.221000	1.38e-08
ZBP1(DAI) mediated induction of type I IFNs	20	8.78e-02	0.220000	1.87e-01
Josephin domain DUBs	10	2.27e-01	0.220000	3.65e-01
Metabolism of amino acids and derivatives	324	9.44e-12	-0.220000	3.06e-10
Oncogene Induced Senescence	33	2.87e-02	0.220000	8.15e-02
Transport of Mature Transcript to Cytoplasm	81	6.35e-04	-0.220000	4.06e-03
Vasopressin regulates renal water homeostasis via Aquaporins	34	2.68e-02	0.219000	7.74e-02
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	38	1.93e-02	-0.219000	5.96e-02
MyD88-independent TLR4 cascade	96	2.10e-04	0.219000	1.72e-03
TRIF(TICAM1)-mediated TLR4 signaling	96	2.10e-04	0.219000	1.72e-03
Nuclear Events (kinase and transcription factor activation)	53	5.86e-03	0.219000	2.31e-02
Diseases associated with glycosylation precursor biosynthesis	18	1.09e-01	0.218000	2.16e-01
TRAF6 mediated NF-kB activation	23	7.03e-02	0.218000	1.58e-01
NOTCH3 Activation and Transmission of Signal to the Nucleus	23	7.05e-02	0.218000	1.58e-01
Viral Messenger RNA Synthesis	44	1.26e-02	-0.217000	4.25e-02
E2F mediated regulation of DNA replication	22	7.79e-02	-0.217000	1.71e-01
Adherens junctions interactions	18	1.11e-01	0.217000	2.19e-01
Acyl chain remodelling of PC	19	1.02e-01	0.217000	2.09e-01
Signaling by Hippo	18	1.12e-01	0.216000	2.19e-01
SUMOylation of DNA damage response and repair proteins	77	1.05e-03	-0.216000	6.05e-03
Inactivation of APC/C via direct inhibition of the APC/C complex	21	8.68e-02	-0.216000	1.86e-01
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	21	8.68e-02	-0.216000	1.86e-01
Regulation of insulin secretion	60	3.85e-03	0.216000	1.64e-02
Transport of bile salts and organic acids, metal ions and amine compounds	55	5.70e-03	0.215000	2.25e-02
GRB2 events in EGFR signaling	11	2.17e-01	0.215000	3.53e-01
Signaling by NOTCH	182	6.06e-07	0.214000	1.01e-05
RNA Polymerase III Transcription Initiation	36	2.61e-02	-0.214000	7.58e-02
Apoptotic execution phase	45	1.29e-02	0.214000	4.33e-02
TRAF6 mediated IRF7 activation	15	1.52e-01	0.213000	2.75e-01
Potential therapeutics for SARS	36	2.67e-02	0.213000	7.72e-02
Vesicle-mediated transport	648	2.00e-20	0.213000	9.72e-19
Listeria monocytogenes entry into host cells	17	1.29e-01	0.213000	2.43e-01
Synthesis of PIPs at the plasma membrane	52	7.99e-03	0.213000	2.93e-02
Assembly and cell surface presentation of NMDA receptors	18	1.19e-01	-0.212000	2.30e-01
Deadenylation-dependent mRNA decay	53	7.56e-03	-0.212000	2.81e-02
Activation of BAD and translocation to mitochondria	15	1.56e-01	0.212000	2.78e-01
Biosynthesis of specialized proresolving mediators (SPMs)	16	1.43e-01	0.211000	2.64e-01
Interconversion of nucleotide di- and triphosphates	27	5.78e-02	-0.211000	1.37e-01
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28	5.36e-02	-0.211000	1.30e-01
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	13	1.89e-01	0.210000	3.18e-01
PLC beta mediated events	43	1.76e-02	0.209000	5.55e-02
Uptake and actions of bacterial toxins	27	6.02e-02	0.209000	1.41e-01
Cytosolic iron-sulfur cluster assembly	13	1.92e-01	-0.209000	3.22e-01
COPI-dependent Golgi-to-ER retrograde traffic	78	1.44e-03	0.209000	7.73e-03
Interleukin-37 signaling	19	1.16e-01	0.208000	2.26e-01
G alpha (z) signalling events	36	3.07e-02	0.208000	8.60e-02
DAP12 interactions	39	2.47e-02	0.208000	7.23e-02
MAP kinase activation	63	4.44e-03	0.207000	1.82e-02
Costimulation by the CD28 family	74	2.14e-03	-0.206000	1.05e-02
mRNA Splicing - Minor Pathway	52	1.05e-02	-0.205000	3.69e-02
Signaling by EGFR	46	1.61e-02	0.205000	5.18e-02
G-protein mediated events	44	1.86e-02	0.205000	5.80e-02
Signaling by Receptor Tyrosine Kinases	414	8.43e-13	0.205000	2.94e-11
Platelet Adhesion to exposed collagen	13	2.01e-01	0.205000	3.33e-01
ER Quality Control Compartment (ERQC)	21	1.06e-01	0.204000	2.13e-01
Glutamate binding, activation of AMPA receptors and synaptic plasticity	20	1.15e-01	0.203000	2.24e-01
Trafficking of AMPA receptors	20	1.15e-01	0.203000	2.24e-01
Signaling by Insulin receptor	59	6.91e-03	0.203000	2.61e-02
Inflammasomes	20	1.17e-01	0.203000	2.26e-01
Processing of SMDT1	15	1.75e-01	-0.202000	3.03e-01
Signaling by NOTCH4	78	2.27e-03	0.200000	1.08e-02
SARS-CoV Infections	83	1.69e-03	0.199000	8.68e-03
Initiation of Nuclear Envelope (NE) Reformation	19	1.33e-01	0.199000	2.47e-01
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17	1.55e-01	-0.199000	2.78e-01
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16	1.68e-01	-0.199000	2.95e-01
Processing of Capped Intron-Containing Pre-mRNA	238	1.29e-07	-0.199000	2.51e-06
SUMOylation of ubiquitinylation proteins	39	3.19e-02	-0.199000	8.80e-02
Initial triggering of complement	78	2.43e-03	-0.199000	1.14e-02
Negative regulation of FGFR3 signaling	20	1.25e-01	0.198000	2.37e-01
Caspase activation via Death Receptors in the presence of ligand	16	1.70e-01	0.198000	2.97e-01
O-linked glycosylation of mucins	47	1.90e-02	0.198000	5.86e-02
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	27	7.52e-02	0.198000	1.66e-01
RUNX2 regulates bone development	23	1.01e-01	0.198000	2.09e-01
PKA activation	15	1.86e-01	0.197000	3.17e-01
Gap-filling DNA repair synthesis and ligation in TC-NER	64	6.34e-03	-0.197000	2.45e-02
RHO GTPase Effectors	250	7.74e-08	0.197000	1.57e-06
Tight junction interactions	18	1.48e-01	-0.197000	2.70e-01
Role of LAT2/NTAL/LAB on calcium mobilization	74	3.66e-03	-0.195000	1.57e-02
CD28 dependent PI3K/Akt signaling	22	1.13e-01	-0.195000	2.21e-01
Regulation of PTEN stability and activity	66	6.11e-03	0.195000	2.38e-02
Carnitine metabolism	10	2.86e-01	0.195000	4.31e-01
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17	1.65e-01	-0.194000	2.90e-01
KSRP (KHSRP) binds and destabilizes mRNA	17	1.66e-01	-0.194000	2.91e-01
FCERI mediated Ca+2 mobilization	89	1.57e-03	-0.194000	8.15e-03
Signaling by NOTCH1	66	6.51e-03	0.194000	2.50e-02
FGFR1 mutant receptor activation	24	1.01e-01	0.194000	2.09e-01
Glycogen storage diseases	13	2.27e-01	0.194000	3.65e-01
Metalloprotease DUBs	21	1.25e-01	0.193000	2.37e-01
PIWI-interacting RNA (piRNA) biogenesis	23	1.09e-01	-0.193000	2.16e-01
Regulation of localization of FOXO transcription factors	11	2.69e-01	0.192000	4.12e-01
Signaling by PDGFRA extracellular domain mutants	12	2.49e-01	0.192000	3.89e-01
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	12	2.49e-01	0.192000	3.89e-01
Ca-dependent events	29	7.34e-02	0.192000	1.63e-01
Cross-presentation of soluble exogenous antigens (endosomes)	47	2.30e-02	0.192000	6.85e-02
APC-Cdc20 mediated degradation of Nek2A	26	9.07e-02	-0.192000	1.92e-01
Sialic acid metabolism	28	7.95e-02	0.191000	1.73e-01
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	64	8.16e-03	0.191000	2.99e-02
Dual incision in TC-NER	65	7.74e-03	-0.191000	2.86e-02
Trafficking and processing of endosomal TLR	13	2.33e-01	0.191000	3.72e-01
TRAF6-mediated induction of TAK1 complex within TLR4 complex	16	1.86e-01	0.191000	3.17e-01
Activation of the AP-1 family of transcription factors	10	2.97e-01	0.191000	4.42e-01
Interleukin-17 signaling	68	6.57e-03	0.191000	2.51e-02
Prostacyclin signalling through prostacyclin receptor	16	1.89e-01	0.190000	3.18e-01
Apoptotic cleavage of cellular proteins	34	5.54e-02	0.190000	1.33e-01
SUMOylation of DNA replication proteins	46	2.61e-02	-0.190000	7.58e-02
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35	5.23e-02	0.190000	1.28e-01
RNA Polymerase II Transcription Termination	65	8.32e-03	-0.189000	3.02e-02
MAPK targets/ Nuclear events mediated by MAP kinases	31	6.84e-02	0.189000	1.55e-01
Cell-extracellular matrix interactions	14	2.21e-01	0.189000	3.58e-01
Telomere Maintenance	80	3.48e-03	-0.189000	1.51e-02
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	53	1.74e-02	0.189000	5.51e-02
Processing of Capped Intronless Pre-mRNA	28	8.38e-02	-0.189000	1.81e-01
SARS-CoV-1 Infection	47	2.58e-02	0.188000	7.52e-02
Interleukin-2 family signaling	38	4.53e-02	0.188000	1.16e-01
A tetrasaccharide linker sequence is required for GAG synthesis	17	1.81e-01	-0.188000	3.09e-01
Role of phospholipids in phagocytosis	88	2.40e-03	-0.187000	1.13e-02
Telomere Extension By Telomerase	23	1.20e-01	-0.187000	2.31e-01
Signaling by FGFR1	38	4.70e-02	0.186000	1.19e-01
Iron uptake and transport	52	2.03e-02	0.186000	6.20e-02
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17	1.85e-01	0.186000	3.16e-01
mRNA Splicing - Major Pathway	179	2.01e-05	-0.185000	2.30e-04
Phospholipid metabolism	186	1.46e-05	0.184000	1.79e-04
MHC class II antigen presentation	101	1.39e-03	0.184000	7.46e-03
Toll Like Receptor 3 (TLR3) Cascade	92	2.29e-03	0.184000	1.08e-02
Regulation of HSF1-mediated heat shock response	79	4.76e-03	-0.184000	1.93e-02
RNA Polymerase III Abortive And Retractive Initiation	41	4.19e-02	-0.184000	1.10e-01
RNA Polymerase III Transcription	41	4.19e-02	-0.184000	1.10e-01
PCP/CE pathway	86	3.24e-03	0.184000	1.44e-02
G0 and Early G1	27	9.91e-02	-0.183000	2.07e-01
Metabolism of lipids	625	5.63e-15	0.183000	2.40e-13
mRNA Splicing	187	1.64e-05	-0.183000	1.90e-04
Rho GTPase cycle	126	4.00e-04	0.183000	2.87e-03
Signaling by Interleukins	385	7.78e-10	0.183000	2.16e-08
SUMOylation of intracellular receptors	25	1.14e-01	0.182000	2.24e-01
Platelet calcium homeostasis	21	1.48e-01	0.182000	2.69e-01
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	20	1.59e-01	-0.182000	2.80e-01
Hedgehog ligand biogenesis	58	1.65e-02	0.182000	5.27e-02
mTORC1-mediated signalling	23	1.31e-01	0.182000	2.45e-01
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78	5.57e-03	-0.182000	2.22e-02
Signaling by Rho GTPases	367	2.45e-09	0.181000	6.19e-08
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	84	4.09e-03	-0.181000	1.71e-02
PI-3K cascade:FGFR2	12	2.78e-01	-0.181000	4.22e-01
Glycerophospholipid biosynthesis	107	1.29e-03	0.180000	7.01e-03
Glycosaminoglycan metabolism	94	2.57e-03	0.180000	1.18e-02
Synthesis of DNA	118	7.45e-04	-0.180000	4.51e-03
Mitochondrial calcium ion transport	22	1.45e-01	-0.179000	2.67e-01
PI Metabolism	80	5.58e-03	0.179000	2.22e-02
Striated Muscle Contraction	23	1.37e-01	0.179000	2.55e-01
Cholesterol biosynthesis	24	1.30e-01	0.179000	2.44e-01
FGFR2 mutant receptor activation	22	1.47e-01	-0.178000	2.69e-01
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	25	1.23e-01	0.178000	2.35e-01
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	51	2.79e-02	0.178000	7.98e-02
NCAM1 interactions	23	1.40e-01	-0.178000	2.59e-01
Formation of Fibrin Clot (Clotting Cascade)	26	1.18e-01	0.177000	2.28e-01
Synthesis of PIPs at the late endosome membrane	11	3.09e-01	0.177000	4.54e-01
Global Genome Nucleotide Excision Repair (GG-NER)	84	5.21e-03	-0.176000	2.10e-02
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	53	2.66e-02	0.176000	7.70e-02
Arachidonic acid metabolism	43	4.58e-02	0.176000	1.17e-01
Collagen formation	66	1.36e-02	0.176000	4.50e-02
SUMOylation of DNA methylation proteins	16	2.24e-01	-0.176000	3.62e-01
Acyl chain remodelling of PI	10	3.38e-01	0.175000	4.85e-01
Ion channel transport	133	5.22e-04	0.174000	3.50e-03
Synthesis of PIPs at the Golgi membrane	16	2.28e-01	0.174000	3.66e-01
Defective CFTR causes cystic fibrosis	59	2.11e-02	0.174000	6.41e-02
mRNA decay by 5' to 3' exoribonuclease	15	2.45e-01	-0.174000	3.85e-01
Elastic fibre formation	32	9.00e-02	0.173000	1.91e-01
Synthesis of IP2, IP, and Ins in the cytosol	13	2.80e-01	0.173000	4.25e-01
Triglyceride metabolism	25	1.35e-01	0.173000	2.50e-01
RUNX1 regulates transcription of genes involved in differentiation of HSCs	82	6.97e-03	0.172000	2.62e-02
Inwardly rectifying K+ channels	23	1.53e-01	0.172000	2.75e-01
Transcriptional regulation of pluripotent stem cells	19	1.94e-01	0.172000	3.24e-01
Effects of PIP2 hydrolysis	24	1.45e-01	-0.172000	2.67e-01
Base Excision Repair	58	2.39e-02	-0.171000	7.07e-02
Downstream signal transduction	27	1.23e-01	0.171000	2.35e-01
Senescence-Associated Secretory Phenotype (SASP)	66	1.64e-02	0.171000	5.25e-02
Tie2 Signaling	16	2.38e-01	0.171000	3.77e-01
Insulin processing	21	1.76e-01	0.170000	3.05e-01
Signaling by FGFR3	31	1.01e-01	0.170000	2.09e-01
G alpha (12/13) signalling events	69	1.46e-02	0.170000	4.79e-02
Muscle contraction	141	4.92e-04	0.170000	3.31e-03
Metabolism of fat-soluble vitamins	28	1.20e-01	0.170000	2.31e-01
Synthesis of bile acids and bile salts	24	1.50e-01	0.170000	2.72e-01
Signaling by WNT in cancer	30	1.08e-01	0.169000	2.15e-01
IRF3-mediated induction of type I IFN	12	3.11e-01	-0.169000	4.55e-01
EGR2 and SOX10-mediated initiation of Schwann cell myelination	22	1.70e-01	0.169000	2.97e-01
S Phase	160	2.31e-04	-0.169000	1.88e-03
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16	2.46e-01	0.168000	3.87e-01
Regulation of ornithine decarboxylase (ODC)	49	4.24e-02	0.168000	1.11e-01
Cobalamin (Cbl, vitamin B12) transport and metabolism	16	2.46e-01	-0.167000	3.87e-01
Oxidative Stress Induced Senescence	79	1.01e-02	0.167000	3.59e-02
Phase 4 - resting membrane potential	10	3.60e-01	0.167000	5.05e-01
Cleavage of the damaged purine	24	1.57e-01	0.167000	2.79e-01
Depurination	24	1.57e-01	0.167000	2.79e-01
Recognition and association of DNA glycosylase with site containing an affected purine	24	1.57e-01	0.167000	2.79e-01
Condensation of Prophase Chromosomes	29	1.20e-01	0.167000	2.31e-01
Cellular response to heat stress	93	5.53e-03	-0.166000	2.22e-02
Mitophagy	28	1.28e-01	-0.166000	2.42e-01
Negative regulation of FGFR4 signaling	21	1.88e-01	0.166000	3.18e-01
Interleukin-6 family signaling	18	2.24e-01	0.166000	3.62e-01
Constitutive Signaling by Overexpressed ERBB2	11	3.43e-01	0.165000	4.87e-01
Regulation of beta-cell development	19	2.13e-01	0.165000	3.48e-01
Disorders of developmental biology	12	3.23e-01	0.165000	4.67e-01
Loss of function of MECP2 in Rett syndrome	12	3.23e-01	0.165000	4.67e-01
Pervasive developmental disorders	12	3.23e-01	0.165000	4.67e-01
DNA Replication	125	1.50e-03	-0.164000	7.95e-03
Regulation of TP53 Activity through Methylation	19	2.16e-01	-0.164000	3.51e-01
NOD1/2 Signaling Pathway	32	1.10e-01	0.163000	2.17e-01
Regulation of TP53 Activity through Association with Co-factors	11	3.49e-01	-0.163000	4.93e-01
Signaling by Activin	10	3.72e-01	-0.163000	5.14e-01
Hh mutants abrogate ligand secretion	54	3.84e-02	0.163000	1.02e-01
Sphingolipid de novo biosynthesis	41	7.38e-02	0.161000	1.64e-01
Programmed Cell Death	169	3.05e-04	0.161000	2.32e-03
TRAF3-dependent IRF activation pathway	13	3.15e-01	0.161000	4.60e-01
Neurotransmitter receptors and postsynaptic signal transmission	123	2.10e-03	0.161000	1.03e-02
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17	2.52e-01	-0.161000	3.92e-01
Autophagy	124	2.10e-03	0.160000	1.03e-02
tRNA processing in the mitochondrion	30	1.31e-01	-0.159000	2.45e-01
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	20	2.17e-01	-0.159000	3.53e-01
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	22	1.96e-01	0.159000	3.26e-01
Apoptosis	166	4.19e-04	0.159000	2.94e-03
Intrinsic Pathway of Fibrin Clot Formation	16	2.73e-01	0.158000	4.17e-01
Regulation of FOXO transcriptional activity by acetylation	10	3.87e-01	0.158000	5.28e-01
Diseases of signal transduction by growth factor receptors and second messengers	340	5.72e-07	0.158000	9.60e-06
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	53	4.74e-02	0.157000	1.19e-01
Constitutive Signaling by NOTCH1 PEST Domain Mutants	53	4.74e-02	0.157000	1.19e-01
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	53	4.74e-02	0.157000	1.19e-01
Signaling by NOTCH1 PEST Domain Mutants in Cancer	53	4.74e-02	0.157000	1.19e-01
Signaling by NOTCH1 in Cancer	53	4.74e-02	0.157000	1.19e-01
p38MAPK events	13	3.26e-01	0.157000	4.70e-01
Constitutive Signaling by EGFRvIII	14	3.09e-01	0.157000	4.54e-01
Signaling by EGFRvIII in Cancer	14	3.09e-01	0.157000	4.54e-01
VEGFR2 mediated vascular permeability	27	1.58e-01	0.157000	2.79e-01
Signaling by Non-Receptor Tyrosine Kinases	48	6.06e-02	0.157000	1.41e-01
Signaling by PTK6	48	6.06e-02	0.157000	1.41e-01
Potassium Channels	63	3.16e-02	0.157000	8.77e-02
Hemostasis	548	3.99e-10	0.156000	1.21e-08
Metabolism of Angiotensinogen to Angiotensins	11	3.71e-01	0.156000	5.13e-01
G1/S Transition	130	2.21e-03	-0.155000	1.07e-02
Synaptic adhesion-like molecules	14	3.17e-01	0.154000	4.62e-01
Regulation of activated PAK-2p34 by proteasome mediated degradation	48	6.53e-02	0.154000	1.49e-01
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	11	3.77e-01	-0.154000	5.19e-01
Defective B3GALT6 causes EDSP2 and SEMDJL1	11	3.80e-01	-0.153000	5.20e-01
RA biosynthesis pathway	13	3.41e-01	-0.153000	4.87e-01
Vitamin B5 (pantothenate) metabolism	17	2.77e-01	0.152000	4.22e-01
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13	3.43e-01	0.152000	4.87e-01
Stimuli-sensing channels	73	2.55e-02	0.151000	7.44e-02
Synthesis, secretion, and deacylation of Ghrelin	12	3.67e-01	-0.150000	5.09e-01
Immune System	1893	2.18e-27	0.150000	1.19e-25
Degradation of DVL	54	5.61e-02	0.150000	1.33e-01
Establishment of Sister Chromatid Cohesion	11	3.89e-01	-0.150000	5.29e-01
Interleukin-4 and Interleukin-13 signaling	92	1.30e-02	0.150000	4.33e-02
Assembly of collagen fibrils and other multimeric structures	42	9.28e-02	0.150000	1.95e-01
APC/C:Cdc20 mediated degradation of Cyclin B	24	2.05e-01	-0.150000	3.37e-01
Nucleotide Excision Repair	110	6.75e-03	-0.150000	2.57e-02
Formation of Incision Complex in GG-NER	43	9.14e-02	-0.149000	1.93e-01
SHC1 events in ERBB2 signaling	17	2.89e-01	0.148000	4.34e-01
Signaling by WNT	253	4.93e-05	0.148000	4.94e-04
ISG15 antiviral mechanism	72	3.02e-02	-0.148000	8.52e-02
p75 NTR receptor-mediated signalling	89	1.61e-02	0.148000	5.18e-02
Olfactory Signaling Pathway	58	5.21e-02	0.147000	1.28e-01
Interleukin-20 family signaling	17	2.93e-01	0.147000	4.37e-01
Transmission across Chemical Synapses	172	8.85e-04	0.147000	5.21e-03
Caspase-mediated cleavage of cytoskeletal proteins	12	3.81e-01	0.146000	5.21e-01
Cilium Assembly	181	6.95e-04	-0.146000	4.24e-03
Beta-catenin independent WNT signaling	136	3.27e-03	0.146000	1.45e-02
Defective B4GALT7 causes EDS, progeroid type	11	4.03e-01	-0.145000	5.43e-01
Citric acid cycle (TCA cycle)	22	2.40e-01	0.145000	3.79e-01
Synthesis of IP3 and IP4 in the cytosol	22	2.40e-01	0.145000	3.79e-01
Inositol phosphate metabolism	42	1.05e-01	0.145000	2.13e-01
Regulation of KIT signaling	15	3.32e-01	0.145000	4.78e-01
Factors involved in megakaryocyte development and platelet production	116	7.17e-03	0.145000	2.68e-02
Hedgehog 'on' state	75	3.07e-02	0.144000	8.60e-02
NGF-stimulated transcription	31	1.64e-01	0.144000	2.89e-01
Nuclear Envelope Breakdown	53	6.95e-02	-0.144000	1.57e-01
Regulation of TP53 Activity through Acetylation	29	1.80e-01	-0.144000	3.09e-01
Signaling by FGFR3 in disease	13	3.69e-01	-0.144000	5.11e-01
Signaling by FGFR3 point mutants in cancer	13	3.69e-01	-0.144000	5.11e-01
ABC transporters in lipid homeostasis	14	3.51e-01	-0.144000	4.96e-01
FCGR3A-mediated IL10 synthesis	99	1.34e-02	-0.144000	4.45e-02
Binding and Uptake of Ligands by Scavenger Receptors	92	1.75e-02	-0.143000	5.52e-02
Peroxisomal lipid metabolism	27	1.99e-01	0.143000	3.30e-01
SHC-mediated cascade:FGFR2	12	3.93e-01	-0.142000	5.33e-01
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	36	1.39e-01	0.142000	2.58e-01
Negative regulation of NOTCH4 signaling	54	7.02e-02	0.142000	1.58e-01
Degradation of GLI1 by the proteasome	57	6.35e-02	0.142000	1.46e-01
Vif-mediated degradation of APOBEC3G	52	7.88e-02	0.141000	1.72e-01
Other semaphorin interactions	16	3.31e-01	0.141000	4.76e-01
GP1b-IX-V activation signalling	10	4.42e-01	0.140000	5.81e-01
Glyoxylate metabolism and glycine degradation	24	2.34e-01	-0.140000	3.73e-01
mRNA 3'-end processing	56	6.95e-02	-0.140000	1.57e-01
ABC transporter disorders	70	4.25e-02	0.140000	1.11e-01
Acetylcholine Neurotransmitter Release Cycle	11	4.21e-01	-0.140000	5.61e-01
Retrograde transport at the Trans-Golgi-Network	49	9.02e-02	0.140000	1.91e-01
Negative regulation of MAPK pathway	42	1.17e-01	0.140000	2.26e-01
Extracellular matrix organization	219	3.70e-04	0.140000	2.74e-03
Signaling by FGFR1 in disease	31	1.81e-01	0.139000	3.09e-01
The role of Nef in HIV-1 replication and disease pathogenesis	28	2.04e-01	0.139000	3.37e-01
CaM pathway	27	2.12e-01	0.139000	3.47e-01
Calmodulin induced events	27	2.12e-01	0.139000	3.47e-01
Glutathione conjugation	26	2.21e-01	0.139000	3.58e-01
Peroxisomal protein import	57	7.04e-02	0.139000	1.58e-01
Chaperonin-mediated protein folding	84	2.83e-02	0.138000	8.08e-02
TICAM1, RIP1-mediated IKK complex recruitment	19	2.99e-01	0.138000	4.44e-01
Negative regulation of NMDA receptor-mediated neuronal transmission	14	3.73e-01	-0.137000	5.14e-01
FGFR2 alternative splicing	25	2.36e-01	-0.137000	3.75e-01
C-type lectin receptors (CLRs)	128	7.55e-03	0.137000	2.81e-02
UCH proteinases	86	2.86e-02	0.137000	8.15e-02
Phosphorylation of the APC/C	20	2.92e-01	-0.136000	4.37e-01
The phototransduction cascade	25	2.40e-01	-0.136000	3.79e-01
Signaling by NOTCH2	30	1.98e-01	0.136000	3.29e-01
The canonical retinoid cycle in rods (twilight vision)	10	4.57e-01	0.136000	5.91e-01
Metabolism of carbohydrates	244	2.62e-04	0.136000	2.05e-03
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	18	3.21e-01	0.135000	4.66e-01
Fatty acyl-CoA biosynthesis	34	1.73e-01	0.135000	3.01e-01
Protein methylation	15	3.66e-01	-0.135000	5.08e-01
TGF-beta receptor signaling activates SMADs	32	1.87e-01	0.135000	3.17e-01
Protein folding	90	2.73e-02	0.135000	7.84e-02
Apoptotic factor-mediated response	18	3.23e-01	0.134000	4.67e-01
Activation of HOX genes during differentiation	68	5.56e-02	0.134000	1.33e-01
Activation of anterior HOX genes in hindbrain development during early embryogenesis	68	5.56e-02	0.134000	1.33e-01
Activation of kainate receptors upon glutamate binding	26	2.39e-01	0.134000	3.78e-01
HS-GAG biosynthesis	20	3.02e-01	0.133000	4.48e-01
Nicotinate metabolism	25	2.49e-01	0.133000	3.89e-01
Lysine catabolism	11	4.47e-01	0.132000	5.83e-01
Neuronal System	258	2.50e-04	0.132000	2.00e-03
Acyl chain remodelling of PG	11	4.49e-01	0.132000	5.84e-01
TCF dependent signaling in response to WNT	165	3.49e-03	0.132000	1.51e-02
NOTCH1 Intracellular Domain Regulates Transcription	44	1.30e-01	0.132000	2.45e-01
Transport of small molecules	557	1.08e-07	0.132000	2.12e-06
Formation of the beta-catenin:TCF transactivating complex	46	1.23e-01	0.131000	2.35e-01
TNFR1-induced proapoptotic signaling	12	4.32e-01	-0.131000	5.71e-01
CDC6 association with the ORC:origin complex	11	4.53e-01	-0.131000	5.86e-01
CD209 (DC-SIGN) signaling	20	3.12e-01	0.131000	4.56e-01
DNA Damage/Telomere Stress Induced Senescence	44	1.34e-01	0.131000	2.50e-01
Signaling by FGFR4	31	2.09e-01	0.130000	3.43e-01
Transcriptional regulation by RUNX2	101	2.37e-02	0.130000	7.00e-02
Antiviral mechanism by IFN-stimulated genes	80	4.44e-02	-0.130000	1.15e-01
Unblocking of NMDA receptors, glutamate binding and activation	12	4.36e-01	-0.130000	5.74e-01
Adrenaline,noradrenaline inhibits insulin secretion	24	2.71e-01	0.130000	4.14e-01
Xenobiotics	11	4.56e-01	-0.130000	5.90e-01
Regulation of Apoptosis	51	1.10e-01	0.129000	2.17e-01
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	52	1.07e-01	0.129000	2.14e-01
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14	4.03e-01	0.129000	5.42e-01
PECAM1 interactions	12	4.39e-01	0.129000	5.77e-01
Transcriptional regulation by RUNX3	90	3.44e-02	0.129000	9.34e-02
Degradation of GLI2 by the proteasome	56	9.69e-02	0.128000	2.03e-01
Metabolic disorders of biological oxidation enzymes	25	2.68e-01	0.128000	4.11e-01
Keratinization	32	2.10e-01	0.128000	3.45e-01
Alpha-protein kinase 1 signaling pathway	11	4.62e-01	0.128000	5.96e-01
E3 ubiquitin ligases ubiquitinate target proteins	52	1.10e-01	0.128000	2.18e-01
DNA Replication Pre-Initiation	82	4.52e-02	-0.128000	1.16e-01
cGMP effects	13	4.25e-01	0.128000	5.65e-01
Regulation of MECP2 expression and activity	28	2.42e-01	0.128000	3.82e-01
Transport of vitamins, nucleosides, and related molecules	33	2.05e-01	0.128000	3.37e-01
Signaling by FGFR2 in disease	32	2.12e-01	-0.127000	3.47e-01
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	80	4.92e-02	0.127000	1.22e-01
Extra-nuclear estrogen signaling	67	7.23e-02	0.127000	1.62e-01
Cell recruitment (pro-inflammatory response)	22	3.03e-01	0.127000	4.49e-01
Purinergic signaling in leishmaniasis infection	22	3.03e-01	0.127000	4.49e-01
Cellular Senescence	144	8.71e-03	0.127000	3.15e-02
Gene expression (Transcription)	1326	1.11e-14	-0.126000	4.43e-13
Signaling by PDGF	44	1.48e-01	0.126000	2.69e-01
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	182	3.37e-03	-0.126000	1.47e-02
Cytosolic sulfonation of small molecules	19	3.42e-01	0.126000	4.87e-01
Response of EIF2AK1 (HRI) to heme deficiency	14	4.15e-01	0.126000	5.54e-01
Regulation of Complement cascade	95	3.42e-02	-0.126000	9.32e-02
RUNX2 regulates osteoblast differentiation	18	3.56e-01	0.126000	5.00e-01
Complement cascade	99	3.13e-02	-0.125000	8.70e-02
Macroautophagy	110	2.33e-02	0.125000	6.92e-02
Signal Transduction	1882	2.53e-19	0.125000	1.19e-17
G alpha (s) signalling events	141	1.07e-02	0.124000	3.74e-02
Interleukin-12 signaling	44	1.54e-01	0.124000	2.77e-01
Depolymerisation of the Nuclear Lamina	15	4.05e-01	0.124000	5.44e-01
Regulation of RUNX3 expression and activity	55	1.11e-01	0.124000	2.19e-01
Inhibition of DNA recombination at telomere	35	2.05e-01	0.124000	3.37e-01
Intracellular signaling by second messengers	271	4.61e-04	0.124000	3.18e-03
Keratan sulfate/keratin metabolism	27	2.66e-01	0.124000	4.09e-01
Interleukin-12 family signaling	53	1.20e-01	0.123000	2.31e-01
CLEC7A (Dectin-1) signaling	96	3.67e-02	0.123000	9.82e-02
CRMPs in Sema3A signaling	14	4.26e-01	0.123000	5.66e-01
Translation of structural proteins	28	2.61e-01	0.123000	4.03e-01
PTEN Regulation	138	1.30e-02	0.122000	4.34e-02
PIP3 activates AKT signaling	239	1.12e-03	0.122000	6.36e-03
ATF4 activates genes in response to endoplasmic reticulum stress	25	2.90e-01	-0.122000	4.34e-01
Cell death signalling via NRAGE, NRIF and NADE	70	7.76e-02	0.122000	1.71e-01
AUF1 (hnRNP D0) binds and destabilizes mRNA	53	1.25e-01	0.122000	2.37e-01
Circadian Clock	67	8.49e-02	0.122000	1.82e-01
Protein ubiquitination	72	7.48e-02	0.121000	1.66e-01
Deubiquitination	241	1.27e-03	0.121000	6.99e-03
DNA Repair	289	4.35e-04	-0.120000	3.04e-03
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26	2.90e-01	-0.120000	4.34e-01
VEGFR2 mediated cell proliferation	18	3.79e-01	0.120000	5.20e-01
Degradation of cysteine and homocysteine	12	4.73e-01	0.120000	6.07e-01
Fatty acid metabolism	152	1.09e-02	0.120000	3.78e-02
Degradation of beta-catenin by the destruction complex	83	6.01e-02	0.119000	1.41e-01
Regulation of RAS by GAPs	66	9.41e-02	0.119000	1.98e-01
Class I MHC mediated antigen processing & presentation	349	1.35e-04	0.119000	1.19e-03
Activation of NF-kappaB in B cells	65	9.75e-02	0.119000	2.04e-01
Tryptophan catabolism	12	4.76e-01	0.119000	6.09e-01
Collagen biosynthesis and modifying enzymes	48	1.55e-01	0.119000	2.78e-01
Ubiquitin-dependent degradation of Cyclin D	50	1.50e-01	0.118000	2.72e-01
Ion transport by P-type ATPases	42	1.88e-01	0.117000	3.18e-01
FCERI mediated MAPK activation	90	5.57e-02	-0.117000	1.33e-01
Regulation of innate immune responses to cytosolic DNA	14	4.51e-01	-0.116000	5.85e-01
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	50	1.56e-01	0.116000	2.78e-01
p53-Independent DNA Damage Response	50	1.56e-01	0.116000	2.78e-01
p53-Independent G1/S DNA damage checkpoint	50	1.56e-01	0.116000	2.78e-01
Defective B3GAT3 causes JDSSDHD	11	5.05e-01	-0.116000	6.35e-01
The role of GTSE1 in G2/M progression after G2 checkpoint	58	1.29e-01	0.115000	2.43e-01
HSF1 activation	26	3.10e-01	-0.115000	4.54e-01
RNA Polymerase I Promoter Clearance	66	1.06e-01	-0.115000	2.13e-01
RNA Polymerase I Transcription	66	1.06e-01	-0.115000	2.13e-01
TP53 Regulates Transcription of Caspase Activators and Caspases	11	5.10e-01	-0.115000	6.39e-01
Cleavage of the damaged pyrimidine	29	2.87e-01	0.114000	4.31e-01
Depyrimidination	29	2.87e-01	0.114000	4.31e-01
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	29	2.87e-01	0.114000	4.31e-01
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16	4.30e-01	0.114000	5.69e-01
Regulation of TP53 Activity through Phosphorylation	88	6.46e-02	-0.114000	1.48e-01
Heparan sulfate/heparin (HS-GAG) metabolism	37	2.32e-01	0.114000	3.70e-01
DAG and IP3 signaling	33	2.60e-01	0.113000	4.02e-01
Biosynthesis of DHA-derived SPMs	14	4.63e-01	0.113000	5.97e-01
Methylation	12	4.99e-01	-0.113000	6.29e-01
Regulation of TP53 Activity	151	1.68e-02	-0.113000	5.33e-02
Degradation of AXIN	53	1.56e-01	0.113000	2.78e-01
Signaling by TGF-beta Receptor Complex	72	9.86e-02	0.113000	2.06e-01
Inactivation, recovery and regulation of the phototransduction cascade	24	3.40e-01	-0.112000	4.87e-01
Elevation of cytosolic Ca2+ levels	12	5.00e-01	0.112000	6.30e-01
Homology Directed Repair	110	4.17e-02	-0.112000	1.10e-01
Insulin receptor signalling cascade	39	2.25e-01	0.112000	3.63e-01
Processing and activation of SUMO	10	5.39e-01	-0.112000	6.66e-01
Signaling by PDGFR in disease	19	3.98e-01	0.112000	5.37e-01
Generic Transcription Pathway	1077	5.38e-10	-0.112000	1.56e-08
Deadenylation of mRNA	22	3.63e-01	-0.112000	5.08e-01
ECM proteoglycans	35	2.53e-01	0.112000	3.93e-01
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30	2.90e-01	0.112000	4.34e-01
Repression of WNT target genes	14	4.70e-01	-0.112000	6.04e-01
Other interleukin signaling	18	4.13e-01	0.111000	5.52e-01
ESR-mediated signaling	162	1.46e-02	0.111000	4.80e-02
MAPK6/MAPK4 signaling	82	8.26e-02	0.111000	1.79e-01
GLI3 is processed to GLI3R by the proteasome	57	1.48e-01	0.111000	2.69e-01
Synthesis of PIPs at the early endosome membrane	16	4.44e-01	0.110000	5.83e-01
FOXO-mediated transcription	58	1.47e-01	0.110000	2.69e-01
Gene Silencing by RNA	87	7.73e-02	-0.110000	1.70e-01
Signaling by ERBB4	44	2.09e-01	0.110000	3.43e-01
PERK regulates gene expression	30	3.00e-01	-0.109000	4.46e-01
Asymmetric localization of PCP proteins	60	1.44e-01	0.109000	2.66e-01
Signaling by GPCR	536	1.59e-05	0.109000	1.86e-04
Formation of TC-NER Pre-Incision Complex	53	1.70e-01	-0.109000	2.97e-01
Death Receptor Signalling	132	3.10e-02	0.109000	8.66e-02
Negative regulation of the PI3K/AKT network	87	7.98e-02	0.109000	1.74e-01
Positive epigenetic regulation of rRNA expression	62	1.39e-01	-0.109000	2.58e-01
DNA Double-Strand Break Repair	135	2.98e-02	-0.108000	8.46e-02
Ras activation upon Ca2+ influx through NMDA receptor	15	4.70e-01	-0.108000	6.04e-01
TP53 Regulates Metabolic Genes	84	8.83e-02	0.108000	1.88e-01
FRS-mediated FGFR2 signaling	14	4.87e-01	-0.107000	6.19e-01
Cytochrome P450 - arranged by substrate type	34	2.81e-01	0.107000	4.25e-01
Signaling by Nuclear Receptors	218	6.89e-03	0.106000	2.61e-02
RNA Polymerase II Transcription	1196	7.42e-10	-0.106000	2.10e-08
Activation of SMO	13	5.09e-01	0.106000	6.39e-01
Metal ion SLC transporters	21	4.05e-01	0.105000	5.44e-01
NIK-->noncanonical NF-kB signaling	57	1.71e-01	0.105000	2.97e-01
Post-translational protein modification	1190	1.08e-09	0.105000	2.83e-08
Ovarian tumor domain proteases	37	2.69e-01	0.105000	4.12e-01
Class I peroxisomal membrane protein import	20	4.17e-01	-0.105000	5.56e-01
Nucleobase catabolism	28	3.37e-01	0.105000	4.84e-01
NF-kB is activated and signals survival	12	5.30e-01	0.105000	6.58e-01
WNT ligand biogenesis and trafficking	21	4.07e-01	0.105000	5.45e-01
Voltage gated Potassium channels	25	3.66e-01	0.105000	5.08e-01
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	27	3.47e-01	-0.104000	4.92e-01
Receptor Mediated Mitophagy	11	5.49e-01	0.104000	6.76e-01
Cardiac conduction	92	8.40e-02	0.104000	1.81e-01
Signaling by EGFR in Cancer	23	3.89e-01	0.104000	5.29e-01
SUMOylation	165	2.19e-02	-0.103000	6.62e-02
NRAGE signals death through JNK	53	1.94e-01	0.103000	3.24e-01
Deposition of new CENPA-containing nucleosomes at the centromere	40	2.60e-01	-0.103000	4.02e-01
Nucleosome assembly	40	2.60e-01	-0.103000	4.02e-01
O-glycosylation of TSR domain-containing proteins	27	3.57e-01	-0.102000	5.01e-01
Dectin-1 mediated noncanonical NF-kB signaling	58	1.80e-01	0.102000	3.09e-01
Organelle biogenesis and maintenance	269	4.21e-03	-0.101000	1.74e-02
Base-Excision Repair, AP Site Formation	31	3.29e-01	0.101000	4.74e-01
Cellular hexose transport	15	4.97e-01	-0.101000	6.28e-01
Metabolism of polyamines	57	1.88e-01	0.101000	3.17e-01
SLC-mediated transmembrane transport	180	1.98e-02	0.101000	6.09e-02
Unfolded Protein Response (UPR)	86	1.07e-01	0.101000	2.13e-01
Signalling to RAS	19	4.48e-01	0.101000	5.83e-01
Mitotic G1 phase and G1/S transition	148	3.50e-02	-0.100000	9.45e-02
DNA Damage Recognition in GG-NER	38	2.86e-01	-0.100000	4.31e-01
GPCR downstream signalling	494	1.40e-04	0.100000	1.23e-03
Autodegradation of the E3 ubiquitin ligase COP1	49	2.26e-01	0.099900	3.65e-01
Nephrin family interactions	17	4.76e-01	-0.099800	6.09e-01
Purine catabolism	16	4.92e-01	-0.099200	6.25e-01
DAP12 signaling	28	3.65e-01	0.098900	5.08e-01
G alpha (q) signalling events	131	5.23e-02	0.098200	1.28e-01
Cristae formation	31	3.44e-01	-0.098100	4.89e-01
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	36	3.10e-01	0.097800	4.54e-01
SIRT1 negatively regulates rRNA expression	24	4.07e-01	0.097700	5.46e-01
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	11	5.75e-01	0.097600	7.01e-01
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10	5.93e-01	-0.097500	7.17e-01
Transcriptional Regulation by MECP2	47	2.48e-01	0.097400	3.89e-01
Aberrant regulation of mitotic exit in cancer due to RB1 defects	20	4.51e-01	-0.097300	5.85e-01
SUMO E3 ligases SUMOylate target proteins	159	3.45e-02	-0.097200	9.35e-02
MASTL Facilitates Mitotic Progression	10	5.95e-01	0.097100	7.17e-01
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	10	5.95e-01	-0.097000	7.17e-01
Defective EXT2 causes exostoses 2	10	5.95e-01	-0.097000	7.17e-01
Resolution of D-loop Structures through Holliday Junction Intermediates	32	3.43e-01	-0.096900	4.87e-01
Vpu mediated degradation of CD4	50	2.39e-01	0.096200	3.79e-01
Negative regulation of FGFR2 signaling	23	4.26e-01	0.095800	5.66e-01
NOTCH2 Activation and Transmission of Signal to the Nucleus	20	4.60e-01	0.095500	5.93e-01
Leishmania infection	245	1.01e-02	0.095500	3.58e-02
PKA-mediated phosphorylation of CREB	17	4.98e-01	0.095000	6.28e-01
Meiotic synapsis	45	2.70e-01	0.095000	4.13e-01
Epigenetic regulation of gene expression	103	9.73e-02	-0.094600	2.04e-01
Nuclear signaling by ERBB4	24	4.25e-01	0.094200	5.65e-01
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	22	4.45e-01	0.094000	5.83e-01
Metabolism of nucleotides	86	1.32e-01	-0.094000	2.46e-01
p75NTR signals via NF-kB	15	5.31e-01	0.093500	6.58e-01
Signaling by FGFR2 IIIa TM	18	4.93e-01	-0.093400	6.25e-01
Peptide ligand-binding receptors	92	1.24e-01	0.092800	2.36e-01
Pexophagy	11	5.94e-01	0.092800	7.17e-01
TP53 Regulates Transcription of DNA Repair Genes	61	2.14e-01	-0.092000	3.49e-01
Heme biosynthesis	14	5.51e-01	0.091900	6.79e-01
Integrin cell surface interactions	52	2.53e-01	0.091600	3.93e-01
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	104	1.07e-01	-0.091400	2.14e-01
Recruitment of NuMA to mitotic centrosomes	80	1.61e-01	-0.090700	2.83e-01
Metabolism of cofactors	19	4.95e-01	0.090500	6.26e-01
Fcgamma receptor (FCGR) dependent phagocytosis	147	5.88e-02	0.090300	1.38e-01
FLT3 Signaling	244	1.52e-02	0.090200	4.96e-02
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72	1.88e-01	0.089600	3.18e-01
PI-3K cascade:FGFR4	10	6.25e-01	-0.089200	7.41e-01
Anchoring of the basal body to the plasma membrane	97	1.29e-01	-0.089100	2.43e-01
Ub-specific processing proteases	170	4.52e-02	0.089000	1.16e-01
Termination of O-glycan biosynthesis	16	5.39e-01	0.088700	6.66e-01
Processing of DNA double-strand break ends	71	1.98e-01	-0.088400	3.28e-01
Mitotic Telophase/Cytokinesis	13	5.83e-01	0.088000	7.08e-01
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	17	5.31e-01	0.087800	6.58e-01
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	17	5.31e-01	0.087800	6.58e-01
Branched-chain amino acid catabolism	21	4.86e-01	-0.087700	6.19e-01
Stabilization of p53	54	2.66e-01	0.087400	4.09e-01
Mitotic Prometaphase	185	4.05e-02	-0.087400	1.07e-01
Ca2+ pathway	57	2.57e-01	0.086800	3.98e-01
Condensation of Prometaphase Chromosomes	11	6.18e-01	0.086800	7.37e-01
Pregnenolone biosynthesis	10	6.36e-01	0.086500	7.52e-01
FRS-mediated FGFR1 signaling	14	5.77e-01	0.086100	7.02e-01
MAPK1/MAPK3 signaling	235	2.31e-02	0.086000	6.88e-02
MAPK family signaling cascades	269	1.56e-02	0.085700	5.03e-02
Regulation of necroptotic cell death	14	5.80e-01	-0.085400	7.05e-01
Mitotic Spindle Checkpoint	108	1.26e-01	-0.085300	2.38e-01
Centrosome maturation	81	1.85e-01	-0.085200	3.16e-01
Recruitment of mitotic centrosome proteins and complexes	81	1.85e-01	-0.085200	3.16e-01
Regulation of PTEN mRNA translation	13	5.96e-01	0.084800	7.18e-01
Downstream signaling of activated FGFR2	19	5.22e-01	-0.084800	6.51e-01
Signaling by Hedgehog	120	1.09e-01	0.084800	2.16e-01
FCERI mediated NF-kB activation	137	8.72e-02	-0.084600	1.86e-01
mRNA Capping	29	4.31e-01	-0.084600	5.69e-01
Regulation of mRNA stability by proteins that bind AU-rich elements	87	1.74e-01	0.084300	3.03e-01
Synthesis of very long-chain fatty acyl-CoAs	21	5.04e-01	0.084200	6.34e-01
HCMV Early Events	74	2.11e-01	-0.084100	3.46e-01
DCC mediated attractive signaling	13	6.00e-01	-0.084000	7.22e-01
G alpha (i) signalling events	244	2.46e-02	0.083600	7.23e-02
Regulation of TP53 Expression and Degradation	36	3.86e-01	-0.083500	5.27e-01
SHC-mediated cascade:FGFR1	12	6.18e-01	0.083200	7.37e-01
RAF-independent MAPK1/3 activation	21	5.09e-01	0.083200	6.39e-01
Signaling by NTRK2 (TRKB)	20	5.23e-01	0.082500	6.52e-01
Endosomal/Vacuolar pathway	12	6.22e-01	-0.082100	7.39e-01
Intrinsic Pathway for Apoptosis	52	3.06e-01	0.082000	4.53e-01
Laminin interactions	21	5.15e-01	0.082000	6.45e-01
Zinc transporters	14	5.95e-01	0.082000	7.17e-01
Signaling by TGFB family members	91	1.78e-01	0.081800	3.07e-01
SCF-beta-TrCP mediated degradation of Emi1	53	3.04e-01	0.081700	4.49e-01
CD28 dependent Vav1 pathway	12	6.27e-01	0.081100	7.42e-01
Downstream TCR signaling	100	1.63e-01	-0.080700	2.87e-01
HCMV Late Events	69	2.46e-01	0.080700	3.87e-01
RAF/MAP kinase cascade	230	3.61e-02	0.080200	9.73e-02
Transcriptional regulation by RUNX1	184	6.06e-02	0.080200	1.41e-01
SUMOylation of transcription factors	16	5.79e-01	0.080200	7.04e-01
CLEC7A (Dectin-1) induces NFAT activation	11	6.46e-01	-0.080100	7.61e-01
NCAM signaling for neurite out-growth	43	3.65e-01	-0.079900	5.08e-01
Interleukin-2 signaling	11	6.49e-01	0.079200	7.65e-01
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	32	4.43e-01	0.078400	5.81e-01
Phase I - Functionalization of compounds	63	2.85e-01	0.077900	4.31e-01
ABC-family proteins mediated transport	93	1.96e-01	0.077600	3.26e-01
Collagen chain trimerization	27	4.85e-01	-0.077600	6.19e-01
Cytokine Signaling in Immune system	735	3.43e-04	0.077600	2.56e-03
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	18	5.69e-01	0.077500	6.94e-01
Signaling by Ligand-Responsive EGFR Variants in Cancer	18	5.69e-01	0.077500	6.94e-01
Defective B3GALTL causes Peters-plus syndrome (PpS)	26	4.94e-01	-0.077400	6.26e-01
Resolution of D-Loop Structures	33	4.44e-01	-0.076900	5.83e-01
RNA Polymerase I Promoter Escape	47	3.62e-01	-0.076900	5.06e-01
ADORA2B mediated anti-inflammatory cytokines production	73	2.57e-01	0.076800	3.98e-01
Regulation of TNFR1 signaling	32	4.53e-01	-0.076600	5.86e-01
Acyl chain remodelling of PE	20	5.54e-01	0.076400	6.82e-01
Post-translational modification: synthesis of GPI-anchored proteins	57	3.19e-01	0.076300	4.64e-01
Estrogen-dependent gene expression	99	1.93e-01	0.075700	3.23e-01
Regulation of actin dynamics for phagocytic cup formation	123	1.49e-01	0.075300	2.71e-01
Peptide hormone metabolism	51	3.52e-01	0.075300	4.96e-01
PRC2 methylates histones and DNA	29	4.83e-01	0.075200	6.17e-01
Synthesis of PE	12	6.53e-01	-0.075000	7.66e-01
ERBB2 Regulates Cell Motility	10	6.82e-01	0.074900	7.83e-01
Nicotinamide salvaging	14	6.31e-01	0.074200	7.46e-01
Signaling by ERBB2	44	3.95e-01	0.074200	5.34e-01
Pyruvate metabolism	28	4.98e-01	0.074100	6.28e-01
Class B/2 (Secretin family receptors)	56	3.38e-01	0.074000	4.85e-01
Regulation of TP53 Degradation	35	4.51e-01	-0.073700	5.85e-01
p53-Dependent G1 DNA Damage Response	63	3.13e-01	0.073600	4.56e-01
p53-Dependent G1/S DNA damage checkpoint	63	3.13e-01	0.073600	4.56e-01
Neurotransmitter release cycle	39	4.27e-01	0.073500	5.66e-01
Activation of RAC1	11	6.74e-01	0.073200	7.76e-01
G2/M DNA damage checkpoint	68	2.99e-01	-0.072900	4.44e-01
Cell junction organization	59	3.40e-01	0.071800	4.87e-01
Cell Cycle	624	2.23e-03	-0.071700	1.07e-02
Negative regulators of DDX58/IFIH1 signaling	34	4.75e-01	-0.070700	6.09e-01
GABA synthesis, release, reuptake and degradation	13	6.61e-01	-0.070300	7.70e-01
Eicosanoid ligand-binding receptors	13	6.61e-01	-0.070200	7.70e-01
Glucose metabolism	84	2.66e-01	0.070200	4.09e-01
Regulation of PTEN gene transcription	59	3.54e-01	0.069800	4.97e-01
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	91	2.52e-01	-0.069500	3.92e-01
Amplification of signal from the kinetochores	91	2.52e-01	-0.069500	3.92e-01
p75NTR recruits signalling complexes	12	6.77e-01	0.069400	7.79e-01
HIV Life Cycle	144	1.51e-01	-0.069400	2.73e-01
NRIF signals cell death from the nucleus	15	6.43e-01	0.069200	7.58e-01
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	18	6.11e-01	-0.069200	7.32e-01
Host Interactions of HIV factors	129	1.75e-01	-0.069200	3.03e-01
Downstream signaling events of B Cell Receptor (BCR)	79	2.89e-01	0.069000	4.34e-01
Basigin interactions	23	5.68e-01	-0.068800	6.94e-01
SHC1 events in ERBB4 signaling	10	7.06e-01	0.068800	7.97e-01
Synthesis of substrates in N-glycan biosythesis	58	3.66e-01	0.068700	5.08e-01
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13	6.70e-01	-0.068200	7.76e-01
Pyruvate metabolism and Citric Acid (TCA) cycle	52	3.97e-01	0.068000	5.36e-01
Cell Cycle Checkpoints	259	6.16e-02	-0.067500	1.43e-01
Switching of origins to a post-replicative state	89	2.76e-01	-0.066900	4.20e-01
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	36	4.88e-01	0.066800	6.20e-01
APC/C:Cdc20 mediated degradation of Securin	66	3.48e-01	0.066700	4.93e-01
Cell-Cell communication	87	2.84e-01	0.066400	4.30e-01
PI3K/AKT Signaling in Cancer	80	3.08e-01	0.065900	4.54e-01
Aflatoxin activation and detoxification	14	6.70e-01	0.065700	7.76e-01
DDX58/IFIH1-mediated induction of interferon-alpha/beta	63	3.74e-01	0.064700	5.15e-01
SCF(Skp2)-mediated degradation of p27/p21	60	3.87e-01	0.064600	5.27e-01
MicroRNA (miRNA) biogenesis	24	5.85e-01	-0.064400	7.09e-01
GPCR ligand binding	229	9.37e-02	0.064300	1.97e-01
RNA polymerase II transcribes snRNA genes	72	3.48e-01	0.064000	4.93e-01
Negative epigenetic regulation of rRNA expression	65	3.78e-01	-0.063200	5.19e-01
FCGR3A-mediated phagocytosis	121	2.31e-01	0.063000	3.70e-01
Leishmania phagocytosis	121	2.31e-01	0.063000	3.70e-01
Parasite infection	121	2.31e-01	0.063000	3.70e-01
Regulation of RUNX2 expression and activity	66	3.79e-01	0.062600	5.20e-01
Molecules associated with elastic fibres	22	6.12e-01	0.062500	7.32e-01
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23	6.04e-01	0.062500	7.25e-01
Protein localization	157	1.80e-01	-0.062000	3.09e-01
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	21	6.24e-01	0.061900	7.40e-01
Resolution of Sister Chromatid Cohesion	104	2.77e-01	-0.061700	4.22e-01
TICAM1,TRAF6-dependent induction of TAK1 complex	11	7.23e-01	0.061700	8.12e-01
Autodegradation of Cdh1 by Cdh1:APC/C	64	3.95e-01	0.061500	5.34e-01
Class A/1 (Rhodopsin-like receptors)	162	1.78e-01	0.061300	3.08e-01
G1/S DNA Damage Checkpoints	65	3.94e-01	0.061100	5.34e-01
TRP channels	17	6.63e-01	0.061000	7.71e-01
Sema3A PAK dependent Axon repulsion	16	6.73e-01	0.060900	7.76e-01
B-WICH complex positively regulates rRNA expression	47	4.71e-01	-0.060800	6.05e-01
G2/M Checkpoints	139	2.17e-01	-0.060600	3.53e-01
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	23	6.21e-01	0.059500	7.39e-01
Signaling by the B Cell Receptor (BCR)	162	1.92e-01	-0.059400	3.22e-01
Ephrin signaling	17	6.72e-01	0.059300	7.76e-01
Ion homeostasis	40	5.18e-01	0.059000	6.48e-01
EML4 and NUDC in mitotic spindle formation	95	3.21e-01	-0.058900	4.66e-01
Regulation of PLK1 Activity at G2/M Transition	87	3.43e-01	-0.058800	4.88e-01
Cargo trafficking to the periciliary membrane	47	4.86e-01	-0.058700	6.19e-01
RAS processing	19	6.60e-01	-0.058400	7.70e-01
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11	7.40e-01	-0.057800	8.26e-01
Signaling by FGFR4 in disease	11	7.43e-01	-0.057100	8.27e-01
Synthesis of glycosylphosphatidylinositol (GPI)	17	6.84e-01	-0.057000	7.85e-01
Downstream signaling of activated FGFR1	20	6.61e-01	0.056700	7.70e-01
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	43	5.21e-01	0.056500	6.51e-01
CDK-mediated phosphorylation and removal of Cdc6	71	4.11e-01	0.056500	5.49e-01
Transport of inorganic cations/anions and amino acids/oligopeptides	79	3.89e-01	0.056100	5.29e-01
Antigen processing: Ubiquitination & Proteasome degradation	288	1.03e-01	0.055800	2.12e-01
Glycolysis	67	4.33e-01	0.055300	5.72e-01
Interleukin-7 signaling	21	6.64e-01	0.054800	7.71e-01
Polo-like kinase mediated events	16	7.05e-01	0.054700	7.97e-01
Phase II - Conjugation of compounds	68	4.47e-01	0.053300	5.83e-01
Loss of Nlp from mitotic centrosomes	69	4.46e-01	-0.053100	5.83e-01
Loss of proteins required for interphase microtubule organization from the centrosome	69	4.46e-01	-0.053100	5.83e-01
Metabolism of folate and pterines	16	7.13e-01	0.053100	8.02e-01
Metabolism of nitric oxide: NOS3 activation and regulation	12	7.51e-01	0.052900	8.33e-01
Neddylation	218	1.87e-01	0.051800	3.17e-01
TCR signaling	121	3.28e-01	-0.051500	4.73e-01
Metabolism	1768	3.32e-04	0.051400	2.50e-03
Prolactin receptor signaling	11	7.68e-01	-0.051300	8.46e-01
Cell Cycle, Mitotic	502	5.21e-02	-0.050600	1.28e-01
RNA Pol II CTD phosphorylation and interaction with CE	27	6.52e-01	-0.050100	7.66e-01
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27	6.52e-01	-0.050100	7.66e-01
Prefoldin mediated transfer of substrate to CCT/TriC	26	6.59e-01	-0.050000	7.70e-01
Diseases of metabolism	190	2.35e-01	0.050000	3.74e-01
Developmental Biology	727	2.27e-02	0.049600	6.80e-02
RMTs methylate histone arginines	37	6.02e-01	-0.049600	7.23e-01
Maturation of nucleoprotein	10	7.86e-01	0.049500	8.57e-01
Signaling by NODAL	13	7.59e-01	-0.049200	8.39e-01
Signaling by BMP	21	7.03e-01	-0.048000	7.96e-01
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	75	4.77e-01	0.047500	6.09e-01
Metabolism of vitamins and cofactors	155	3.07e-01	0.047500	4.53e-01
HCMV Infection	96	4.23e-01	0.047300	5.64e-01
Orc1 removal from chromatin	69	4.99e-01	-0.047100	6.29e-01
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	31	6.51e-01	-0.047000	7.66e-01
Downregulation of ERBB2:ERBB3 signaling	12	7.81e-01	-0.046400	8.52e-01
Diseases associated with N-glycosylation of proteins	17	7.42e-01	-0.046200	8.27e-01
Phase 2 - plateau phase	18	7.35e-01	0.046100	8.23e-01
Diseases associated with glycosaminoglycan metabolism	26	6.86e-01	0.045800	7.86e-01
HATs acetylate histones	93	4.47e-01	-0.045600	5.83e-01
Biological oxidations	136	3.64e-01	0.045100	5.08e-01
TP53 Regulates Transcription of Cell Cycle Genes	48	5.90e-01	-0.044900	7.15e-01
PI-3K cascade:FGFR1	12	7.88e-01	0.044900	8.58e-01
Constitutive Signaling by NOTCH1 HD Domain Mutants	14	7.71e-01	0.044900	8.48e-01
Signaling by NOTCH1 HD Domain Mutants in Cancer	14	7.71e-01	0.044900	8.48e-01
Formation of RNA Pol II elongation complex	57	5.58e-01	0.044900	6.84e-01
RNA Polymerase II Transcription Elongation	57	5.58e-01	0.044900	6.84e-01
CDT1 association with the CDC6:ORC:origin complex	57	5.58e-01	0.044800	6.84e-01
Processing of Intronless Pre-mRNAs	19	7.36e-01	-0.044700	8.23e-01
Disorders of transmembrane transporters	147	3.53e-01	0.044400	4.96e-01
Nonhomologous End-Joining (NHEJ)	42	6.21e-01	0.044100	7.39e-01
Adaptive Immune System	756	3.94e-02	0.044000	1.05e-01
Interferon Signaling	177	3.12e-01	-0.044000	4.56e-01
Signaling by ERBB2 ECD mutants	15	7.68e-01	0.044000	8.46e-01
Mitotic Prophase	98	4.52e-01	0.044000	5.85e-01
Chondroitin sulfate/dermatan sulfate metabolism	38	6.42e-01	0.043500	7.58e-01
SHC-mediated cascade:FGFR4	10	8.13e-01	-0.043200	8.80e-01
SLC transporter disorders	77	5.13e-01	-0.043100	6.42e-01
HIV elongation arrest and recovery	32	6.73e-01	0.043100	7.76e-01
Pausing and recovery of HIV elongation	32	6.73e-01	0.043100	7.76e-01
Late Phase of HIV Life Cycle	131	4.03e-01	-0.042300	5.43e-01
Neurexins and neuroligins	37	6.56e-01	-0.042300	7.69e-01
Transcriptional regulation by small RNAs	63	5.62e-01	-0.042300	6.88e-01
APC/C:Cdc20 mediated degradation of mitotic proteins	74	5.30e-01	0.042200	6.58e-01
Nitric oxide stimulates guanylate cyclase	16	7.72e-01	0.041900	8.48e-01
Disease	1299	1.13e-02	0.041900	3.89e-02
Transcriptional activation of mitochondrial biogenesis	51	6.13e-01	0.040900	7.33e-01
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	124	4.32e-01	-0.040800	5.71e-01
RIPK1-mediated regulated necrosis	16	7.79e-01	0.040600	8.50e-01
Regulated Necrosis	16	7.79e-01	0.040600	8.50e-01
TP53 Regulates Transcription of Death Receptors and Ligands	11	8.16e-01	-0.040500	8.82e-01
Dopamine Neurotransmitter Release Cycle	20	7.55e-01	-0.040400	8.36e-01
Netrin-1 signaling	40	6.61e-01	0.040000	7.70e-01
Cyclin A/B1/B2 associated events during G2/M transition	25	7.30e-01	0.039800	8.20e-01
Mitochondrial Fatty Acid Beta-Oxidation	36	6.80e-01	-0.039700	7.82e-01
Gamma carboxylation, hypusine formation and arylsulfatase activation	34	6.89e-01	-0.039700	7.89e-01
Interleukin-35 Signalling	12	8.12e-01	-0.039600	8.80e-01
TP53 Regulates Transcription of Cell Death Genes	42	6.57e-01	0.039600	7.69e-01
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	72	5.65e-01	0.039200	6.92e-01
Hedgehog 'off' state	92	5.28e-01	0.038100	6.57e-01
Purine salvage	12	8.21e-01	0.037800	8.84e-01
Post NMDA receptor activation events	48	6.51e-01	0.037700	7.66e-01
Amino acid transport across the plasma membrane	23	7.54e-01	0.037700	8.36e-01
Visual phototransduction	59	6.18e-01	0.037600	7.37e-01
Glutathione synthesis and recycling	10	8.39e-01	-0.037100	8.99e-01
IGF1R signaling cascade	36	7.01e-01	0.037000	7.94e-01
Keratan sulfate biosynthesis	22	7.65e-01	0.036700	8.44e-01
AURKA Activation by TPX2	72	5.90e-01	-0.036700	7.15e-01
Aberrant regulation of mitotic cell cycle due to RB1 defects	36	7.07e-01	-0.036200	7.97e-01
Diseases of mitotic cell cycle	36	7.07e-01	-0.036200	7.97e-01
TNFR2 non-canonical NF-kB pathway	95	5.43e-01	-0.036100	6.70e-01
N-glycan antennae elongation in the medial/trans-Golgi	21	7.75e-01	0.036000	8.49e-01
O-linked glycosylation	84	5.69e-01	0.035900	6.94e-01
Transcriptional Regulation by VENTX	38	7.04e-01	-0.035600	7.96e-01
Cyclin D associated events in G1	47	6.73e-01	0.035500	7.76e-01
G1 Phase	47	6.73e-01	0.035500	7.76e-01
Diseases associated with O-glycosylation of proteins	49	6.67e-01	-0.035500	7.75e-01
Chromatin modifying enzymes	217	3.72e-01	0.035100	5.14e-01
Chromatin organization	217	3.72e-01	0.035100	5.14e-01
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18	7.98e-01	0.034900	8.66e-01
Transcription of the HIV genome	67	6.23e-01	-0.034800	7.39e-01
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	71	6.13e-01	0.034800	7.33e-01
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	46	6.84e-01	0.034700	7.85e-01
Respiratory electron transport	101	5.48e-01	-0.034600	6.76e-01
Formation of HIV-1 elongation complex containing HIV-1 Tat	42	6.99e-01	-0.034500	7.93e-01
HIV Transcription Elongation	42	6.99e-01	-0.034500	7.93e-01
Tat-mediated elongation of the HIV-1 transcript	42	6.99e-01	-0.034500	7.93e-01
IRAK2 mediated activation of TAK1 complex	10	8.51e-01	0.034400	9.06e-01
Formation of the Early Elongation Complex	33	7.34e-01	-0.034200	8.22e-01
Formation of the HIV-1 Early Elongation Complex	33	7.34e-01	-0.034200	8.22e-01
Nef mediated downregulation of MHC class I complex cell surface expression	10	8.52e-01	-0.034000	9.07e-01
Downregulation of TGF-beta receptor signaling	26	7.65e-01	0.033900	8.44e-01
CASP8 activity is inhibited	11	8.47e-01	-0.033500	9.03e-01
Dimerization of procaspase-8	11	8.47e-01	-0.033500	9.03e-01
Regulation by c-FLIP	11	8.47e-01	-0.033500	9.03e-01
HIV Transcription Initiation	45	6.99e-01	-0.033300	7.93e-01
RNA Polymerase II HIV Promoter Escape	45	6.99e-01	-0.033300	7.93e-01
RNA Polymerase II Promoter Escape	45	6.99e-01	-0.033300	7.93e-01
RNA Polymerase II Transcription Initiation	45	6.99e-01	-0.033300	7.93e-01
RNA Polymerase II Transcription Initiation And Promoter Clearance	45	6.99e-01	-0.033300	7.93e-01
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	45	6.99e-01	-0.033300	7.93e-01
PI3K events in ERBB2 signaling	11	8.53e-01	-0.032300	9.07e-01
NoRC negatively regulates rRNA expression	62	6.60e-01	-0.032300	7.70e-01
Signaling by FGFR in disease	51	6.94e-01	0.031900	7.93e-01
GRB2 events in ERBB2 signaling	11	8.61e-01	-0.030600	9.09e-01
Acyl chain remodelling of PS	14	8.46e-01	0.030000	9.03e-01
Chaperone Mediated Autophagy	20	8.19e-01	-0.029600	8.83e-01
Cellular responses to stress	499	2.59e-01	-0.029500	4.01e-01
Formation of ATP by chemiosmotic coupling	18	8.29e-01	0.029500	8.89e-01
Signaling by FGFR	69	6.74e-01	0.029300	7.76e-01
Complex I biogenesis	55	7.09e-01	-0.029100	7.98e-01
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	13	8.56e-01	-0.029000	9.08e-01
Transcriptional Regulation by TP53	351	3.52e-01	-0.028900	4.96e-01
Mitochondrial iron-sulfur cluster biogenesis	13	8.59e-01	-0.028500	9.08e-01
Lewis blood group biosynthesis	13	8.59e-01	0.028500	9.08e-01
Glutamate Neurotransmitter Release Cycle	20	8.30e-01	-0.027700	8.89e-01
Anti-inflammatory response favouring Leishmania parasite infection	169	5.34e-01	-0.027700	6.61e-01
Leishmania parasite growth and survival	169	5.34e-01	-0.027700	6.61e-01
DNA Double Strand Break Response	47	7.43e-01	0.027700	8.27e-01
Pausing and recovery of Tat-mediated HIV elongation	30	7.97e-01	0.027100	8.66e-01
Tat-mediated HIV elongation arrest and recovery	30	7.97e-01	0.027100	8.66e-01
Blood group systems biosynthesis	17	8.47e-01	0.027100	9.03e-01
Meiotic recombination	38	7.76e-01	0.026700	8.49e-01
MECP2 regulates neuronal receptors and channels	13	8.68e-01	0.026600	9.13e-01
HS-GAG degradation	16	8.55e-01	0.026300	9.08e-01
Nuclear Envelope (NE) Reassembly	69	7.08e-01	0.026100	7.98e-01
Fertilization	12	8.77e-01	0.025800	9.20e-01
Activation of BH3-only proteins	29	8.13e-01	0.025400	8.80e-01
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	24	8.29e-01	0.025400	8.89e-01
Signaling by ERBB2 TMD/JMD mutants	17	8.57e-01	-0.025200	9.08e-01
PKMTs methylate histone lysines	44	7.72e-01	-0.025200	8.48e-01
Serotonin Neurotransmitter Release Cycle	15	8.67e-01	0.025000	9.13e-01
Interferon alpha/beta signaling	57	7.47e-01	0.024700	8.31e-01
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	73	7.22e-01	0.024100	8.11e-01
Syndecan interactions	19	8.60e-01	0.023300	9.09e-01
FRS-mediated FGFR3 signaling	11	8.94e-01	0.023200	9.31e-01
Signaling by Retinoic Acid	31	8.25e-01	-0.022900	8.86e-01
Cellular responses to external stimuli	505	3.81e-01	-0.022800	5.21e-01
Cell surface interactions at the vascular wall	174	6.11e-01	-0.022400	7.32e-01
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	12	8.95e-01	-0.022000	9.31e-01
Protein-protein interactions at synapses	57	7.76e-01	0.021800	8.49e-01
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	10	9.05e-01	0.021700	9.38e-01
Signaling by ERBB2 KD Mutants	20	8.69e-01	-0.021400	9.13e-01
Sulfur amino acid metabolism	23	8.61e-01	0.021000	9.09e-01
Signaling by FGFR2	60	7.84e-01	-0.020400	8.55e-01
Constitutive Signaling by Aberrant PI3K in Cancer	54	7.97e-01	-0.020300	8.66e-01
Formation of HIV elongation complex in the absence of HIV Tat	44	8.18e-01	-0.020100	8.82e-01
Synthesis of PA	32	8.44e-01	0.020100	9.03e-01
RNA Polymerase II Pre-transcription Events	78	7.60e-01	0.020000	8.39e-01
Downstream signaling of activated FGFR4	17	8.89e-01	-0.019600	9.28e-01
Interferon gamma signaling	83	7.59e-01	-0.019400	8.39e-01
FRS-mediated FGFR4 signaling	12	9.10e-01	-0.018800	9.42e-01
Phase 0 - rapid depolarisation	28	8.64e-01	-0.018700	9.11e-01
Formation of tubulin folding intermediates by CCT/TriC	22	8.80e-01	0.018600	9.21e-01
Infectious disease	723	3.99e-01	-0.018400	5.38e-01
Activation of NMDA receptors and postsynaptic events	58	8.13e-01	0.017900	8.80e-01
Diseases of glycosylation	109	7.47e-01	0.017900	8.31e-01
The citric acid (TCA) cycle and respiratory electron transport	172	6.94e-01	-0.017400	7.93e-01
Cytosolic sensors of pathogen-associated DNA	62	8.16e-01	-0.017100	8.82e-01
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	37	8.57e-01	0.017100	9.08e-01
Glucagon-type ligand receptors	20	8.96e-01	0.016800	9.31e-01
Class C/3 (Metabotropic glutamate/pheromone receptors)	12	9.20e-01	-0.016700	9.47e-01
Miscellaneous transport and binding events	20	8.99e-01	0.016400	9.33e-01
FOXO-mediated transcription of cell cycle genes	15	9.14e-01	-0.016200	9.43e-01
STING mediated induction of host immune responses	15	9.14e-01	-0.016000	9.43e-01
Aggrephagy	22	8.97e-01	0.016000	9.31e-01
N-Glycan antennae elongation	13	9.20e-01	0.016000	9.47e-01
Signaling by NTRK3 (TRKC)	16	9.14e-01	-0.015600	9.43e-01
Regulation of RUNX1 Expression and Activity	18	9.09e-01	0.015600	9.41e-01
Antimicrobial peptides	33	8.83e-01	0.014900	9.23e-01
MET activates PTK2 signaling	15	9.22e-01	0.014600	9.48e-01
IRS-related events triggered by IGF1R	35	8.82e-01	0.014500	9.22e-01
Separation of Sister Chromatids	167	7.49e-01	-0.014400	8.31e-01
Cyclin E associated events during G1/S transition	83	8.25e-01	0.014000	8.86e-01
Metabolism of proteins	1715	3.50e-01	0.013600	4.93e-01
Fc epsilon receptor (FCERI) signaling	190	7.48e-01	-0.013500	8.31e-01
Mitotic Anaphase	223	7.37e-01	0.013100	8.23e-01
Selective autophagy	58	8.71e-01	-0.012400	9.14e-01
TNF signaling	42	8.92e-01	0.012200	9.30e-01
Downregulation of ERBB2 signaling	24	9.19e-01	-0.011900	9.47e-01
Meiosis	68	8.65e-01	-0.011900	9.11e-01
Signaling by ERBB2 in Cancer	21	9.32e-01	0.010800	9.55e-01
Norepinephrine Neurotransmitter Release Cycle	14	9.44e-01	-0.010800	9.66e-01
Cell-cell junction organization	38	9.11e-01	0.010500	9.42e-01
Receptor-type tyrosine-protein phosphatases	12	9.50e-01	0.010500	9.68e-01
CTLA4 inhibitory signaling	21	9.34e-01	0.010500	9.56e-01
Metabolism of water-soluble vitamins and cofactors	109	8.54e-01	0.010200	9.08e-01
Lysosphingolipid and LPA receptors	11	9.56e-01	-0.009620	9.74e-01
APC/C-mediated degradation of cell cycle proteins	86	8.79e-01	0.009490	9.21e-01
Regulation of mitotic cell cycle	86	8.79e-01	0.009490	9.21e-01
Downstream signaling of activated FGFR3	16	9.49e-01	0.009200	9.68e-01
M Phase	360	7.73e-01	0.008860	8.48e-01
Mitotic Metaphase and Anaphase	224	8.20e-01	0.008840	8.83e-01
HIV Infection	224	8.23e-01	-0.008660	8.86e-01
IL-6-type cytokine receptor ligand interactions	12	9.61e-01	0.008150	9.77e-01
Mitochondrial biogenesis	88	8.97e-01	-0.008020	9.31e-01
Cohesin Loading onto Chromatin	10	9.67e-01	0.007580	9.81e-01
Assembly of the pre-replicative complex	66	9.21e-01	0.007080	9.47e-01
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	29	9.49e-01	0.006810	9.68e-01
TICAM1-dependent activation of IRF3/IRF7	12	9.69e-01	-0.006580	9.81e-01
Deactivation of the beta-catenin transactivating complex	36	9.46e-01	0.006500	9.67e-01
Non-integrin membrane-ECM interactions	37	9.46e-01	0.006400	9.67e-01
Attenuation phase	23	9.58e-01	0.006360	9.75e-01
Reproduction	80	9.23e-01	-0.006240	9.48e-01
G2/M Transition	180	8.88e-01	-0.006060	9.28e-01
Cyclin A:Cdk2-associated events at S phase entry	85	9.24e-01	0.005970	9.49e-01
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14	9.70e-01	-0.005800	9.82e-01
HSF1-dependent transactivation	29	9.59e-01	-0.005520	9.75e-01
Interaction between L1 and Ankyrins	22	9.65e-01	0.005380	9.80e-01
RHO GTPases Activate Formins	117	9.27e-01	0.004880	9.51e-01
Signaling by KIT in disease	20	9.74e-01	0.004280	9.82e-01
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	20	9.74e-01	0.004280	9.82e-01
Kinesins	39	9.64e-01	0.004220	9.79e-01
TNFR1-induced NFkappaB signaling pathway	25	9.74e-01	-0.003800	9.82e-01
Axon guidance	455	8.96e-01	-0.003570	9.31e-01
SUMOylation of transcription cofactors	44	9.72e-01	0.003100	9.82e-01
PI3K Cascade	30	9.78e-01	-0.002900	9.85e-01
CD28 co-stimulation	33	9.77e-01	-0.002840	9.85e-01
IRS-mediated signalling	34	9.83e-01	-0.002090	9.88e-01
Regulation of APC/C activators between G1/S and early anaphase	79	9.80e-01	-0.001670	9.85e-01
Mitotic G2-G2/M phases	182	9.70e-01	0.001630	9.82e-01
Abortive elongation of HIV-1 transcript in the absence of Tat	23	9.90e-01	0.001450	9.93e-01
Association of TriC/CCT with target proteins during biosynthesis	37	9.90e-01	-0.001170	9.93e-01
Nuclear Receptor transcription pathway	36	9.90e-01	0.001150	9.93e-01
Regulation of pyruvate dehydrogenase (PDH) complex	15	9.95e-01	-0.000919	9.97e-01
Nucleotide-like (purinergic) receptors	12	9.96e-01	0.000917	9.97e-01
Nervous system development	474	9.80e-01	0.000685	9.85e-01
Incretin synthesis, secretion, and inactivation	10	9.99e-01	-0.000241	9.99e-01
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	10	9.99e-01	-0.000241	9.99e-01

---

Detailed Gene set reports

IRAK4 deficiency (TLR2/4)

IRAK4 deficiency (TLR2/4)

	511
set	IRAK4 deficiency (TLR2/4)
setSize	10
pANOVA	2.19e-06
s.dist	0.864
p.adjustANOVA	3.11e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYD88	11331
CD36	10947
BTK	10849
TLR2	10535
TLR1	10059
TLR4	9549
CD14	9466
LY96	9322
TLR6	9070
TIRAP	8858

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYD88	11331
CD36	10947
BTK	10849
TLR2	10535
TLR1	10059
TLR4	9549
CD14	9466
LY96	9322
TLR6	9070
TIRAP	8858

---

MyD88 deficiency (TLR2/4)

MyD88 deficiency (TLR2/4)

	684
set	MyD88 deficiency (TLR2/4)
setSize	10
pANOVA	2.19e-06
s.dist	0.864
p.adjustANOVA	3.11e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYD88	11331
CD36	10947
BTK	10849
TLR2	10535
TLR1	10059
TLR4	9549
CD14	9466
LY96	9322
TLR6	9070
TIRAP	8858

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYD88	11331
CD36	10947
BTK	10849
TLR2	10535
TLR1	10059
TLR4	9549
CD14	9466
LY96	9322
TLR6	9070
TIRAP	8858

---

Peptide chain elongation

Peptide chain elongation

	806
set	Peptide chain elongation
setSize	88
pANOVA	5.06e-36
s.dist	-0.771
p.adjustANOVA	6.88e-34

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
EEF1A1	-9751
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
EEF1A1	-9751
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EEF2	-6279
RPL8	-6101
RPLP1	-6018
RPL28	-3873
FAU	-3618
UBA52	-3490
RPL39L	-1661
RPS26	-1154
RPS27L	-496
RPS4Y1	331
RPS9	1841
RPL3L	5150
RPL26L1	6001

---

Eukaryotic Translation Elongation

Eukaryotic Translation Elongation

	349
set	Eukaryotic Translation Elongation
setSize	93
pANOVA	1.44e-37
s.dist	-0.767
p.adjustANOVA	2.18e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
EEF1A1	-9751
EEF1B2	-9732
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
EEF1A1	-9751
EEF1B2	-9732
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
EEF1G	-9293
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EEF2	-6279
RPL8	-6101
RPLP1	-6018
EEF1A1P5	-5877
EEF1D	-5664
RPL28	-3873
FAU	-3618
UBA52	-3490
EEF1A2	-3246
RPL39L	-1661
RPS26	-1154
RPS27L	-496
RPS4Y1	331
RPS9	1841
RPL3L	5150
RPL26L1	6001

---

Selenocysteine synthesis

Selenocysteine synthesis

	1058
set	Selenocysteine synthesis
setSize	92
pANOVA	1.36e-35
s.dist	-0.75
p.adjustANOVA	1.68e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
SEPSECS	-7958
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
SECISBP2	-6992
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EEFSEC	-6493
RPL8	-6101
SARS1	-6044
RPLP1	-6018
PSTK	-5710
RPL28	-3873
FAU	-3618
UBA52	-3490
RPL39L	-1661
RPS26	-1154
RPS27L	-496
RPS4Y1	331
RPS9	1841
RPL3L	5150
RPL26L1	6001
SEPHS2	8084

---

Viral mRNA Translation

Viral mRNA Translation

	1313
set	Viral mRNA Translation
setSize	88
pANOVA	6.76e-34
s.dist	-0.747
p.adjustANOVA	6.14e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
RPL8	-6101
RPLP1	-6018
RPL28	-3873
FAU	-3618
UBA52	-3490
GRSF1	-2923
RPL39L	-1661
RPS26	-1154
RPS27L	-496
RPS4Y1	331
RPS9	1841
RPL3L	5150
RPL26L1	6001
DNAJC3	9831

---

Formation of a pool of free 40S subunits

Formation of a pool of free 40S subunits

	391
set	Formation of a pool of free 40S subunits
setSize	100
pANOVA	4.05e-38
s.dist	-0.746
p.adjustANOVA	6.88e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
EIF3E	-9049
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
EIF3L	-8255
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
EIF3H	-7091
RPL37A	-6833
RPL9	-6821
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EIF3J	-6448
RPL8	-6101
RPLP1	-6018
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
RPL28	-3873
FAU	-3618
UBA52	-3490
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
RPL39L	-1661
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
RPS9	1841
RPL3L	5150
RPL26L1	6001

---

Eukaryotic Translation Termination

Eukaryotic Translation Termination

	351
set	Eukaryotic Translation Termination
setSize	92
pANOVA	3.3e-34
s.dist	-0.734
p.adjustANOVA	3.21e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
N6AMT1	-9282
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
GSPT2	-7995
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
RPL8	-6101
RPLP1	-6018
RPL28	-3873
FAU	-3618
UBA52	-3490
TRMT112	-2296
GSPT1	-2025
RPL39L	-1661
RPS26	-1154
RPS27L	-496
RPS4Y1	331
RPS9	1841
APEH	4945
RPL3L	5150
RPL26L1	6001
ETF1	6835

---

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

	1328
set	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
setSize	12
pANOVA	1.52e-05
s.dist	0.721
p.adjustANOVA	0.000179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACSL1	11102
ACAA1	11076
FADS1	10870
ACOT8	10822
ACOX1	10277
ELOVL1	9841
ELOVL3	9553
HSD17B4	8942
ABCD1	7994
FADS2	7216
ELOVL5	5665
SCP2	-1980

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACSL1	11102
ACAA1	11076
FADS1	10870
ACOT8	10822
ACOX1	10277
ELOVL1	9841
ELOVL3	9553
HSD17B4	8942
ABCD1	7994
FADS2	7216
ELOVL5	5665
SCP2	-1980

---

alpha-linolenic acid (ALA) metabolism

alpha-linolenic acid (ALA) metabolism

	1329
set	alpha-linolenic acid (ALA) metabolism
setSize	12
pANOVA	1.52e-05
s.dist	0.721
p.adjustANOVA	0.000179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ACSL1	11102
ACAA1	11076
FADS1	10870
ACOT8	10822
ACOX1	10277
ELOVL1	9841
ELOVL3	9553
HSD17B4	8942
ABCD1	7994
FADS2	7216
ELOVL5	5665
SCP2	-1980

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ACSL1	11102
ACAA1	11076
FADS1	10870
ACOT8	10822
ACOX1	10277
ELOVL1	9841
ELOVL3	9553
HSD17B4	8942
ABCD1	7994
FADS2	7216
ELOVL5	5665
SCP2	-1980

---

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

	742
set	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
setSize	94
pANOVA	1.58e-32
s.dist	-0.708
p.adjustANOVA	1.2e-30

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
NCBP2	-9631
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
NCBP2	-9631
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
GSPT2	-7995
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
RPL8	-6101
RPLP1	-6018
RPL28	-3873
FAU	-3618
UBA52	-3490
PABPC1	-2991
GSPT1	-2025
RPL39L	-1661
RPS26	-1154
NCBP1	-942
RPS27L	-496
RPS4Y1	331
RPS9	1841
RPL3L	5150
RPL26L1	6001
ETF1	6835
UPF1	9103
EIF4G1	10506

---

Translocation of ZAP-70 to Immunological synapse

Translocation of ZAP-70 to Immunological synapse

	1276
set	Translocation of ZAP-70 to Immunological synapse
setSize	24
pANOVA	1.98e-09
s.dist	-0.707
p.adjustANOVA	5.09e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
HLA-DQB2	-9656
LCK	-9556
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
HLA-DQA2	-8774
ZAP70	-8755
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD4	-6881
HLA-DQA1	-6389
TRAV8-4	-4769

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
HLA-DQB2	-9656
LCK	-9556
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
HLA-DQA2	-8774
ZAP70	-8755
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD4	-6881
HLA-DQA1	-6389
TRAV8-4	-4769
HLA-DQB1	-4459
HLA-DRB1	-334
HLA-DRB5	748
PTPN22	6966

---

L13a-mediated translational silencing of Ceruloplasmin expression

L13a-mediated translational silencing of Ceruloplasmin expression

	587
set	L13a-mediated translational silencing of Ceruloplasmin expression
setSize	110
pANOVA	7.55e-35
s.dist	-0.678
p.adjustANOVA	8.56e-33

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
EIF3E	-9049
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
EIF3L	-8255
RPL22L1	-8202
EIF4B	-8190
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
EIF3H	-7091
RPL37A	-6833
RPL9	-6821
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EIF3J	-6448
RPL8	-6101
RPLP1	-6018
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
RPL28	-3873
FAU	-3618
UBA52	-3490
PABPC1	-2991
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
RPL39L	-1661
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
RPL3L	5150
EIF4A1	5541
RPL26L1	6001
EIF4H	7768
EIF4G1	10506

---

GTP hydrolysis and joining of the 60S ribosomal subunit

GTP hydrolysis and joining of the 60S ribosomal subunit

	433
set	GTP hydrolysis and joining of the 60S ribosomal subunit
setSize	111
pANOVA	1.11e-34
s.dist	-0.674
p.adjustANOVA	1.16e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
EIF3E	-9049
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
EIF3L	-8255
RPL22L1	-8202
EIF4B	-8190
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
EIF3H	-7091
EIF5B	-6867
RPL37A	-6833
RPL9	-6821
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EIF3J	-6448
RPL8	-6101
RPLP1	-6018
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
RPL28	-3873
FAU	-3618
UBA52	-3490
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
RPL39L	-1661
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
EIF5	2937
RPL3L	5150
EIF4A1	5541
RPL26L1	6001
EIF4H	7768
EIF4G1	10506

---

Response of EIF2AK4 (GCN2) to amino acid deficiency

Response of EIF2AK4 (GCN2) to amino acid deficiency

	1006
set	Response of EIF2AK4 (GCN2) to amino acid deficiency
setSize	100
pANOVA	3.17e-31
s.dist	-0.672
p.adjustANOVA	2.27e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
ASNS	-7772
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
RPL8	-6101
RPLP1	-6018
GCN1	-5625
IMPACT	-5597
ATF3	-4287
RPL28	-3873
FAU	-3618
UBA52	-3490
RPL39L	-1661
EIF2AK4	-1656
EIF2S1	-1649
RPS26	-1154
ATF2	-657
RPS27L	-496
ATF4	-54
RPS4Y1	331
EIF2S2	554
RPS9	1841
TRIB3	2492
EIF2S3	2500
CEBPG	4210
RPL3L	5150
RPL26L1	6001
DDIT3	6480
CEBPB	11136

---

Formation of the ternary complex, and subsequently, the 43S complex

Formation of the ternary complex, and subsequently, the 43S complex

	397
set	Formation of the ternary complex, and subsequently, the 43S complex
setSize	51
pANOVA	1.92e-16
s.dist	-0.665
p.adjustANOVA	8.41e-15

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637
RPS16	-8579

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPS21	-8330
RPS18	-8321
RPS17	-8281
EIF3L	-8255
RPS28	-8083
RPS11	-7975
RPS19	-7806
EIF3H	-7091
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPSA	-6629
EIF3J	-6448
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
FAU	-3618
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
RPS9	1841
EIF2S3	2500

---

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

	1321
set	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
setSize	11
pANOVA	0.000155
s.dist	0.659
p.adjustANOVA	0.00133

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FZD5	11440
AP2A1	11340
CLTC	10304
AP2A2	10223
AP2M1	8799
AP2S1	8045
CLTB	7968
CLTA	7164
FZD2	5116
AP2B1	2910
ROR1	2194

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FZD5	11440
AP2A1	11340
CLTC	10304
AP2A2	10223
AP2M1	8799
AP2S1	8045
CLTB	7968
CLTA	7164
FZD2	5116
AP2B1	2910
ROR1	2194

---

Regulation of TLR by endogenous ligand

Regulation of TLR by endogenous ligand

	966
set	Regulation of TLR by endogenous ligand
setSize	11
pANOVA	0.000234
s.dist	0.641
p.adjustANOVA	0.00188

Top enriched genes

Top 20 genes

GeneID	Gene Rank
S100A8	11184
CD36	10947
S100A9	10613
TLR2	10535
TLR1	10059
TLR4	9549
CD14	9466
LY96	9322
TLR6	9070
S100A1	-688
HMGB1	-6699

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
S100A8	11184
CD36	10947
S100A9	10613
TLR2	10535
TLR1	10059
TLR4	9549
CD14	9466
LY96	9322
TLR6	9070
S100A1	-688
HMGB1	-6699

---

Major pathway of rRNA processing in the nucleolus and cytosol

Major pathway of rRNA processing in the nucleolus and cytosol

	624
set	Major pathway of rRNA processing in the nucleolus and cytosol
setSize	180
pANOVA	6.06e-50
s.dist	-0.641
p.adjustANOVA	2.06e-47

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPP40	-10069
NOP58	-10031
RPL23A	-9979
GNL3	-9960
RPL3	-9957
FBL	-9942
NOL11	-9932
RPL5	-9881
RPS3A	-9834
WDR75	-9823
RPL7	-9765
EXOSC2	-9753
TSR1	-9724
RPS27A	-9723
UTP4	-9700
RPS6	-9699
RPL14	-9698
LAS1L	-9679
RPS25	-9664
RPL22	-9659

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPP40	-10069
NOP58	-10031
RPL23A	-9979
GNL3	-9960
RPL3	-9957
FBL	-9942
NOL11	-9932
RPL5	-9881
RPS3A	-9834
WDR75	-9823
RPL7	-9765
EXOSC2	-9753
TSR1	-9724
RPS27A	-9723
UTP4	-9700
RPS6	-9699
RPL14	-9698
LAS1L	-9679
RPS25	-9664
RPL22	-9659
NOP14	-9641
BMS1	-9626
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
NOP56	-9444
RPS20	-9413
RPL13A	-9402
WDR43	-9395
RPS23	-9387
EXOSC8	-9379
RPL32	-9345
NCL	-9336
DDX47	-9334
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
UTP15	-9156
RPL11	-9117
RPL17	-9116
WDR46	-9056
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
TEX10	-8915
RPL36A	-8909
NOB1	-8908
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
MPHOSPH10	-8840
EXOSC9	-8793
NOL9	-8786
RPL31	-8769
EMG1	-8744
RPS13	-8724
RPL26	-8706
RPP25	-8688
RPS4X	-8648
RPP30	-8640
RPS29	-8637
RPL39	-8635
RPL29	-8621
UTP6	-8616
RRP9	-8598
RPS16	-8579
RPS14	-8541
SNU13	-8495
RPS10	-8494
EXOSC7	-8473
EXOSC5	-8394
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
PELP1	-8232
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RIOK2	-8079
PNO1	-8004
RPS11	-7975
RPL38	-7968
EBNA1BP2	-7916
RPL37	-7861
NOL6	-7834
RPL27	-7810
RPS19	-7806
NIP7	-7779
KRR1	-7720
RCL1	-7690
RPP38	-7683
RPL13	-7671
DCAF13	-7564
RPL41	-7561
RPL36	-7493
EXOSC6	-7458
UTP20	-7427
HEATR1	-7278
IMP4	-7155
PES1	-7148
LTV1	-7119
WDR3	-7016
IMP3	-6912
RPL37A	-6833
EXOSC10	-6829
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
BOP1	-6593
PDCD11	-6547
CSNK1E	-6526
RPL8	-6101
RPLP1	-6018
RBM28	-5712
PWP2	-5423
RRP7A	-5246
WDR36	-5072
BYSL	-4898
RIOK1	-4858
UTP3	-4821
DHX37	-4742
MTREX	-4495
RPP21	-4260
DIS3	-4140
RPL28	-3873
WDR18	-3817
FAU	-3618
UBA52	-3490
UTP14A	-3323
MPHOSPH6	-3194
RRP1	-3051
UTP14C	-2415
RPP14	-2204
RPL39L	-1661
FTSJ3	-1199
DDX21	-1198
RPS26	-1154
WDR12	-731
RPS27L	-496
EXOSC1	-493
RRP36	-395
C1D	-325
EXOSC3	-40
UTP11	-37
SENP3	78
RPS4Y1	331
FCF1	453
TBL3	739
NOC4L	1606
DDX52	1795
RPS9	1841
ISG20L2	3150
UTP18	3850
DDX49	4083
NOL12	4277
RPL3L	5150
RPL26L1	6001
ERI1	6679
RIOK3	7088
CSNK1D	8475
EXOSC4	10040
XRN2	10267
SNORD3A	10596

---

Cap-dependent Translation Initiation

Cap-dependent Translation Initiation

	142
set	Cap-dependent Translation Initiation
setSize	118
pANOVA	2.65e-33
s.dist	-0.64
p.adjustANOVA	2.12e-31

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
EIF3E	-9049
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
EIF3L	-8255
RPL22L1	-8202
EIF4B	-8190
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
EIF3H	-7091
EIF5B	-6867
RPL37A	-6833
RPL9	-6821
RPS24	-6818
EIF3M	-6817
RPS15	-6703
EIF2B3	-6649
RPL36AL	-6646
RPSA	-6629
EIF3J	-6448
RPL8	-6101
RPLP1	-6018
EIF2B5	-5580
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
RPL28	-3873
FAU	-3618
UBA52	-3490
PABPC1	-2991
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
EIF2B1	-2228
RPL39L	-1661
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
EIF4EBP1	2825
EIF5	2937
EIF2B4	4294
RPL3L	5150
EIF4A1	5541
RPL26L1	6001
EIF2B2	7498
EIF4H	7768
EIF4G1	10506

---

Eukaryotic Translation Initiation

Eukaryotic Translation Initiation

	350
set	Eukaryotic Translation Initiation
setSize	118
pANOVA	2.65e-33
s.dist	-0.64
p.adjustANOVA	2.12e-31

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
EIF4A2	-9593
RPS2	-9591
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
EIF3E	-9049
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
EIF3L	-8255
RPL22L1	-8202
EIF4B	-8190
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
EIF3H	-7091
EIF5B	-6867
RPL37A	-6833
RPL9	-6821
RPS24	-6818
EIF3M	-6817
RPS15	-6703
EIF2B3	-6649
RPL36AL	-6646
RPSA	-6629
EIF3J	-6448
RPL8	-6101
RPLP1	-6018
EIF2B5	-5580
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
RPL28	-3873
FAU	-3618
UBA52	-3490
PABPC1	-2991
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
EIF2B1	-2228
RPL39L	-1661
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
EIF4EBP1	2825
EIF5	2937
EIF2B4	4294
RPL3L	5150
EIF4A1	5541
RPL26L1	6001
EIF2B2	7498
EIF4H	7768
EIF4G1	10506

---

rRNA processing in the nucleus and cytosol

rRNA processing in the nucleus and cytosol

	1353
set	rRNA processing in the nucleus and cytosol
setSize	190
pANOVA	7.19e-52
s.dist	-0.636
p.adjustANOVA	4.89e-49

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DKC1	-10139
RPP40	-10069
NOP58	-10031
RPL23A	-9979
GNL3	-9960
RPL3	-9957
FBL	-9942
NOL11	-9932
RPL5	-9881
RPS3A	-9834
NAT10	-9828
WDR75	-9823
THUMPD1	-9782
RPL7	-9765
EXOSC2	-9753
TSR1	-9724
RPS27A	-9723
UTP4	-9700
RPS6	-9699
RPL14	-9698

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DKC1	-10139
RPP40	-10069
NOP58	-10031
RPL23A	-9979
GNL3	-9960
RPL3	-9957
FBL	-9942
NOL11	-9932
RPL5	-9881
RPS3A	-9834
NAT10	-9828
WDR75	-9823
THUMPD1	-9782
RPL7	-9765
EXOSC2	-9753
TSR1	-9724
RPS27A	-9723
UTP4	-9700
RPS6	-9699
RPL14	-9698
LAS1L	-9679
RPS25	-9664
RPL22	-9659
DIMT1	-9652
NOP14	-9641
BMS1	-9626
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
NOP56	-9444
RPS20	-9413
RPL13A	-9402
WDR43	-9395
RPS23	-9387
EXOSC8	-9379
RPL32	-9345
NCL	-9336
DDX47	-9334
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
UTP15	-9156
RPL11	-9117
RPL17	-9116
WDR46	-9056
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
TEX10	-8915
RPL36A	-8909
NOB1	-8908
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
MPHOSPH10	-8840
EXOSC9	-8793
NOL9	-8786
RPL31	-8769
EMG1	-8744
RPS13	-8724
RPL26	-8706
RPP25	-8688
RPS4X	-8648
RPP30	-8640
RPS29	-8637
RPL39	-8635
RPL29	-8621
UTP6	-8616
RRP9	-8598
RPS16	-8579
RPS14	-8541
SNU13	-8495
RPS10	-8494
EXOSC7	-8473
EXOSC5	-8394
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
NOP2	-8307
RPL7A	-8286
RPS17	-8281
PELP1	-8232
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RIOK2	-8079
PNO1	-8004
RPS11	-7975
RPL38	-7968
EBNA1BP2	-7916
RPL37	-7861
NOL6	-7834
RPL27	-7810
RPS19	-7806
NIP7	-7779
KRR1	-7720
RCL1	-7690
RPP38	-7683
RPL13	-7671
DCAF13	-7564
RPL41	-7561
RPL36	-7493
EXOSC6	-7458
UTP20	-7427
GAR1	-7407
HEATR1	-7278
IMP4	-7155
PES1	-7148
LTV1	-7119
WDR3	-7016
IMP3	-6912
RPL37A	-6833
EXOSC10	-6829
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
BOP1	-6593
PDCD11	-6547
NHP2	-6535
CSNK1E	-6526
RPL8	-6101
RPLP1	-6018
RBM28	-5712
PWP2	-5423
RRP7A	-5246
WDR36	-5072
BYSL	-4898
RIOK1	-4858
UTP3	-4821
DHX37	-4742
MTREX	-4495
RPP21	-4260
DIS3	-4140
RPL28	-3873
WDR18	-3817
FAU	-3618
UBA52	-3490
UTP14A	-3323
MPHOSPH6	-3194
RRP1	-3051
UTP14C	-2415
TRMT112	-2296
RPP14	-2204
RPL39L	-1661
FTSJ3	-1199
DDX21	-1198
RPS26	-1154
WDR12	-731
RPS27L	-496
EXOSC1	-493
RRP36	-395
C1D	-325
EXOSC3	-40
UTP11	-37
SENP3	78
RPS4Y1	331
FCF1	453
TBL3	739
TSR3	1498
NOC4L	1606
DDX52	1795
RPS9	1841
ISG20L2	3150
UTP18	3850
DDX49	4083
NOL12	4277
RPL3L	5150
RPL26L1	6001
ERI1	6679
RIOK3	7088
CSNK1D	8475
EXOSC4	10040
XRN2	10267
NOP10	10379
SNORD3A	10596

---

Selenoamino acid metabolism

Selenoamino acid metabolism

	1057
set	Selenoamino acid metabolism
setSize	114
pANOVA	2.44e-30
s.dist	-0.62
p.adjustANOVA	1.58e-28

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
LARS1	-9637
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
LARS1	-9637
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
IARS1	-8999
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
KARS1	-8380
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
AIMP1	-7990
RPS11	-7975
RPL38	-7968
SEPSECS	-7958
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
SCLY	-7645
RPL41	-7561
RPL36	-7493
SECISBP2	-6992
DARS1	-6939
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
EEFSEC	-6493
EPRS1	-6350
RPL8	-6101
SARS1	-6044
RPLP1	-6018
PSTK	-5710
RARS1	-3944
RPL28	-3873
QARS1	-3758
FAU	-3618
UBA52	-3490
AIMP2	-3343
EEF1E1	-2716
AHCY	-2510
RPL39L	-1661
RPS26	-1154
CTH	-637
RPS27L	-496
INMT	-384
RPS4Y1	331
RPS9	1841
GNMT	2920
RPL3L	5150
RPL26L1	6001
HNMT	6423
MARS1	7358
SEPHS2	8084
TXNRD1	9890
PAPSS1	10336
GSR	11051
CBS	11232
PAPSS2	11267

---

RHO GTPases Activate ROCKs

RHO GTPases Activate ROCKs

	886
set	RHO GTPases Activate ROCKs
setSize	18
pANOVA	6.3e-06
s.dist	0.615
p.adjustANOVA	8.41e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYL6	10185
PAK1	10043
CFL1	9794
LIMK2	9689
RHOA	9401
MYH9	9224
ROCK1	8695
MYH10	8632
PPP1R12B	8489
LIMK1	8062
RHOB	7921
PPP1R12A	7801
PPP1CB	6745
ROCK2	6611
MYL12B	5703
RHOC	4639
MYL9	1931
MYH11	-2243

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYL6	10185
PAK1	10043
CFL1	9794
LIMK2	9689
RHOA	9401
MYH9	9224
ROCK1	8695
MYH10	8632
PPP1R12B	8489
LIMK1	8062
RHOB	7921
PPP1R12A	7801
PPP1CB	6745
ROCK2	6611
MYL12B	5703
RHOC	4639
MYL9	1931
MYH11	-2243

---

Uptake and function of anthrax toxins

Uptake and function of anthrax toxins

	1304
set	Uptake and function of anthrax toxins
setSize	10
pANOVA	0.000817
s.dist	0.611
p.adjustANOVA	0.00492

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAP2K6	10958
FURIN	10905
MAP2K3	10377
MAP2K1	10148
PDCD6IP	9293
MAP2K4	7754
MAP2K2	7222
ANTXR2	5636
MAP2K7	1550
CALM1	-1245

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAP2K6	10958
FURIN	10905
MAP2K3	10377
MAP2K1	10148
PDCD6IP	9293
MAP2K4	7754
MAP2K2	7222
ANTXR2	5636
MAP2K7	1550
CALM1	-1245

---

Activation of the pre-replicative complex

Activation of the pre-replicative complex

	50
set	Activation of the pre-replicative complex
setSize	32
pANOVA	2.71e-09
s.dist	-0.607
p.adjustANOVA	6.59e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM3	-9943
POLA1	-9841
RPA1	-9799
MCM7	-9325
POLE3	-9287
RPA3	-9220
PRIM1	-9166
DBF4	-8907
MCM6	-8631
ORC5	-8539
ORC2	-8256
POLA2	-7950
ORC3	-7889
POLE2	-7763
PRIM2	-7112
MCM4	-7086
MCM2	-6880
ORC4	-6267
MCM8	-5713
CDC45	-5132

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM3	-9943
POLA1	-9841
RPA1	-9799
MCM7	-9325
POLE3	-9287
RPA3	-9220
PRIM1	-9166
DBF4	-8907
MCM6	-8631
ORC5	-8539
ORC2	-8256
POLA2	-7950
ORC3	-7889
POLE2	-7763
PRIM2	-7112
MCM4	-7086
MCM2	-6880
ORC4	-6267
MCM8	-5713
CDC45	-5132
RPA2	-4811
MCM10	-4587
CDC7	-4493
POLE	-4081
CDK2	-3614
CDT1	-3436
ORC1	-2973
MCM5	-2327
POLE4	-1856
CDC6	-1597
GMNN	2164
ORC6	5337

---

MET activates RAP1 and RAC1

MET activates RAP1 and RAC1

	618
set	MET activates RAP1 and RAC1
setSize	10
pANOVA	0.00102
s.dist	0.6
p.adjustANOVA	0.00589

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GRB2	10733
RAC1	10624
HGF	10417
CRK	10387
GAB1	8670
RAP1A	7335
RAP1B	6962
CRKL	5250
RAPGEF1	5102
DOCK7	-4084

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GRB2	10733
RAC1	10624
HGF	10417
CRK	10387
GAB1	8670
RAP1A	7335
RAP1B	6962
CRKL	5250
RAPGEF1	5102
DOCK7	-4084

---

rRNA processing

rRNA processing

	1351
set	rRNA processing
setSize	217
pANOVA	2.08e-51
s.dist	-0.593
p.adjustANOVA	9.44e-49

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DKC1	-10139
RPP40	-10069
NOP58	-10031
RPL23A	-9979
GNL3	-9960
RPL3	-9957
FBL	-9942
NOL11	-9932
MTERF4	-9917
RPL5	-9881
RPS3A	-9834
NAT10	-9828
WDR75	-9823
THUMPD1	-9782
RPL7	-9765
EXOSC2	-9753
TSR1	-9724
RPS27A	-9723
UTP4	-9700
RPS6	-9699

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DKC1	-10139
RPP40	-10069
NOP58	-10031
RPL23A	-9979
GNL3	-9960
RPL3	-9957
FBL	-9942
NOL11	-9932
MTERF4	-9917
RPL5	-9881
RPS3A	-9834
NAT10	-9828
WDR75	-9823
THUMPD1	-9782
RPL7	-9765
EXOSC2	-9753
TSR1	-9724
RPS27A	-9723
UTP4	-9700
RPS6	-9699
RPL14	-9698
LAS1L	-9679
RPS25	-9664
RPL22	-9659
DIMT1	-9652
NOP14	-9641
BMS1	-9626
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
NOP56	-9444
RPS20	-9413
RPL13A	-9402
WDR43	-9395
RPS23	-9387
EXOSC8	-9379
RPL32	-9345
NCL	-9336
DDX47	-9334
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
UTP15	-9156
RPL11	-9117
RPL17	-9116
WDR46	-9056
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
TEX10	-8915
RPL36A	-8909
NOB1	-8908
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
MPHOSPH10	-8840
EXOSC9	-8793
NOL9	-8786
RPL31	-8769
EMG1	-8744
RPS13	-8724
RPL26	-8706
RPP25	-8688
RPS4X	-8648
RPP30	-8640
RPS29	-8637
RPL39	-8635
RPL29	-8621
UTP6	-8616
RRP9	-8598
RPS16	-8579
RPS14	-8541
MRM1	-8526
SNU13	-8495
RPS10	-8494
EXOSC7	-8473
EXOSC5	-8394
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
NOP2	-8307
TRMT10C	-8306
RPL7A	-8286
RPS17	-8281
PELP1	-8232
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RIOK2	-8079
PNO1	-8004
RPS11	-7975
RPL38	-7968
EBNA1BP2	-7916
RPL37	-7861
NOL6	-7834
RPL27	-7810
RPS19	-7806
NIP7	-7779
KRR1	-7720
RCL1	-7690
RPP38	-7683
RPL13	-7671
DCAF13	-7564
RPL41	-7561
RPL36	-7493
EXOSC6	-7458
UTP20	-7427
GAR1	-7407
HEATR1	-7278
IMP4	-7155
PES1	-7148
LTV1	-7119
WDR3	-7016
IMP3	-6912
TFB1M	-6859
RPL37A	-6833
EXOSC10	-6829
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
BOP1	-6593
PDCD11	-6547
NHP2	-6535
CSNK1E	-6526
RPL8	-6101
MT-ND2	-6095
RPLP1	-6018
RBM28	-5712
MRM3	-5709
MT-ND3	-5522
PWP2	-5423
ELAC2	-5385
RRP7A	-5246
MRM2	-5169
MT-CO3	-5157
MT-RNR1	-5094
MT-ND1	-5075
WDR36	-5072
BYSL	-4898
RIOK1	-4858
UTP3	-4821
DHX37	-4742
MTREX	-4495
RPP21	-4260
DIS3	-4140
RPL28	-3873
WDR18	-3817
FAU	-3618
UBA52	-3490
UTP14A	-3323
MPHOSPH6	-3194
RRP1	-3051
MT-CO2	-2523
UTP14C	-2415
TRMT112	-2296
RPP14	-2204
MT-ATP6	-2202
MT-CYB	-2032
PRORP	-1720
RPL39L	-1661
FTSJ3	-1199
DDX21	-1198
RPS26	-1154
MT-ND5	-931
WDR12	-731
RPS27L	-496
EXOSC1	-493
MT-CO1	-454
MT-RNR2	-408
RRP36	-395
C1D	-325
EXOSC3	-40
UTP11	-37
SENP3	78
MT-ATP8	189
RPS4Y1	331
FCF1	453
TBL3	739
TSR3	1498
NOC4L	1606
DDX52	1795
RPS9	1841
MT-ND4L	2323
NSUN4	2338
MT-TF	2765
HSD17B10	2981
ISG20L2	3150
MT-TV	3363
UTP18	3850
DDX49	4083
NOL12	4277
MT-ND4	4493
MT-TL1	4517
RPL3L	5150
RPL26L1	6001
ERI1	6679
RIOK3	7088
CSNK1D	8475
EXOSC4	10040
XRN2	10267
NOP10	10379
SNORD3A	10596

---

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

	741
set	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
setSize	114
pANOVA	1.63e-27
s.dist	-0.588
p.adjustANOVA	9.23e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
NCBP2	-9631
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
NCBP2	-9631
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
UPF3A	-8795
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RNPS1	-8030
GSPT2	-7995
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
MAGOHB	-6726
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
RPL8	-6101
RPLP1	-6018
UPF3B	-5843
DCP1A	-4839
MAGOH	-4678
RPL28	-3873
PNRC2	-3729
FAU	-3618
UBA52	-3490
PABPC1	-2991
GSPT1	-2025
RPL39L	-1661
RBM8A	-1499
RPS26	-1154
NCBP1	-942
RPS27L	-496
SMG1	-489
SMG6	-480
RPS4Y1	331
UPF2	1281
EIF4A3	1507
PPP2R2A	1788
RPS9	1841
SMG5	4864
SMG8	4994
RPL3L	5150
PPP2R1A	5189
RPL26L1	6001
SMG9	6262
PPP2CA	6806
ETF1	6835
UPF1	9103
CASC3	9610
SMG7	10376
EIF4G1	10506

---

Nonsense-Mediated Decay (NMD)

Nonsense-Mediated Decay (NMD)

	743
set	Nonsense-Mediated Decay (NMD)
setSize	114
pANOVA	1.63e-27
s.dist	-0.588
p.adjustANOVA	9.23e-26

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
NCBP2	-9631
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
NCBP2	-9631
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
UPF3A	-8795
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RNPS1	-8030
GSPT2	-7995
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
MAGOHB	-6726
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
RPL8	-6101
RPLP1	-6018
UPF3B	-5843
DCP1A	-4839
MAGOH	-4678
RPL28	-3873
PNRC2	-3729
FAU	-3618
UBA52	-3490
PABPC1	-2991
GSPT1	-2025
RPL39L	-1661
RBM8A	-1499
RPS26	-1154
NCBP1	-942
RPS27L	-496
SMG1	-489
SMG6	-480
RPS4Y1	331
UPF2	1281
EIF4A3	1507
PPP2R2A	1788
RPS9	1841
SMG5	4864
SMG8	4994
RPL3L	5150
PPP2R1A	5189
RPL26L1	6001
SMG9	6262
PPP2CA	6806
ETF1	6835
UPF1	9103
CASC3	9610
SMG7	10376
EIF4G1	10506

---

rRNA modification in the nucleus and cytosol

rRNA modification in the nucleus and cytosol

	1350
set	rRNA modification in the nucleus and cytosol
setSize	59
pANOVA	5.93e-15
s.dist	-0.587
p.adjustANOVA	2.45e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DKC1	-10139
NOP58	-10031
FBL	-9942
NOL11	-9932
NAT10	-9828
WDR75	-9823
THUMPD1	-9782
UTP4	-9700
RPS6	-9699
DIMT1	-9652
NOP14	-9641
BMS1	-9626
RPS2	-9591
NOP56	-9444
WDR43	-9395
DDX47	-9334
RPS7	-9165
UTP15	-9156
WDR46	-9056
MPHOSPH10	-8840

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DKC1	-10139
NOP58	-10031
FBL	-9942
NOL11	-9932
NAT10	-9828
WDR75	-9823
THUMPD1	-9782
UTP4	-9700
RPS6	-9699
DIMT1	-9652
NOP14	-9641
BMS1	-9626
RPS2	-9591
NOP56	-9444
WDR43	-9395
DDX47	-9334
RPS7	-9165
UTP15	-9156
WDR46	-9056
MPHOSPH10	-8840
EMG1	-8744
UTP6	-8616
RRP9	-8598
RPS14	-8541
SNU13	-8495
NOP2	-8307
PNO1	-8004
NOL6	-7834
KRR1	-7720
RCL1	-7690
DCAF13	-7564
UTP20	-7427
GAR1	-7407
HEATR1	-7278
IMP4	-7155
WDR3	-7016
IMP3	-6912
PDCD11	-6547
NHP2	-6535
PWP2	-5423
RRP7A	-5246
WDR36	-5072
UTP3	-4821
DHX37	-4742
UTP14A	-3323
UTP14C	-2415
TRMT112	-2296
RRP36	-395
UTP11	-37
FCF1	453
TBL3	739
TSR3	1498
NOC4L	1606
DDX52	1795
RPS9	1841
UTP18	3850
DDX49	4083
NOP10	10379
SNORD3A	10596

---

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

	1038
set	SRP-dependent cotranslational protein targeting to membrane
setSize	111
pANOVA	1.23e-26
s.dist	-0.586
p.adjustANOVA	6.19e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
RPS2	-9591
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
SRPRB	-7520
RPL36	-7493
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
TRAM1	-6480
RPL8	-6101
SEC11C	-6046
RPLP1	-6018
SEC61A2	-5333
RPL28	-3873
FAU	-3618
SRP72	-3562
UBA52	-3490
SRP9	-3414
SEC61G	-3152
SSR2	-2917
SPCS1	-1700
RPL39L	-1661
RPS26	-1154
SPCS2	-977
SRP19	-625
RPS27L	-496
RPS4Y1	331
SRP68	787
SSR1	1143
SSR4	1294
RPS9	1841
SPCS3	1967
SSR3	2510
SEC61B	4322
SRP14	5022
RPL3L	5150
RPL26L1	6001
SEC11A	6634
RPN1	7151
SEC61A1	7486
SRP54	7912
SRPRA	8301
DDOST	8464
RPN2	8874

---

Translation initiation complex formation

Translation initiation complex formation

	1267
set	Translation initiation complex formation
setSize	58
pANOVA	1.23e-14
s.dist	-0.585
p.adjustANOVA	4.8e-13

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
EIF4A2	-9593
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
EIF4A2	-9593
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPS21	-8330
RPS18	-8321
RPS17	-8281
EIF3L	-8255
EIF4B	-8190
RPS28	-8083
RPS11	-7975
RPS19	-7806
EIF3H	-7091
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPSA	-6629
EIF3J	-6448
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
FAU	-3618
PABPC1	-2991
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
EIF4A1	5541
EIF4H	7768
EIF4G1	10506

---

Nucleobase biosynthesis

Nucleobase biosynthesis

	753
set	Nucleobase biosynthesis
setSize	13
pANOVA	0.000288
s.dist	-0.581
p.adjustANOVA	0.00222

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IMPDH2	-10126
ATIC	-10062
PPAT	-10019
UMPS	-9982
PAICS	-9454
PFAS	-9385
CAD	-8818
ADSL	-6382
DHODH	-5973
GMPS	-5196
LHPP	-3573
GART	4563
IMPDH1	11303

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IMPDH2	-10126
ATIC	-10062
PPAT	-10019
UMPS	-9982
PAICS	-9454
PFAS	-9385
CAD	-8818
ADSL	-6382
DHODH	-5973
GMPS	-5196
LHPP	-3573
GART	4563
IMPDH1	11303

---

Influenza Viral RNA Transcription and Replication

Influenza Viral RNA Transcription and Replication

	526
set	Influenza Viral RNA Transcription and Replication
setSize	135
pANOVA	5.44e-31
s.dist	-0.576
p.adjustANOVA	3.7e-29

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IPO5	-10129
NDC1	-10077
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
NUP35	-9726
RPS27A	-9723
RPS6	-9699
RPL14	-9698
NUP88	-9668
RPS25	-9664
RPL22	-9659
RPS2	-9591
SEH1L	-9574
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IPO5	-10129
NDC1	-10077
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
NUP35	-9726
RPS27A	-9723
RPS6	-9699
RPL14	-9698
NUP88	-9668
RPS25	-9664
RPL22	-9659
RPS2	-9591
SEH1L	-9574
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
PARP1	-8391
RPL23	-8373
NUP43	-8368
NUP160	-8357
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
NUP107	-8285
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
NUP188	-7953
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
NUP205	-7516
RPL36	-7493
NUP54	-7131
NUP155	-7061
POLR2D	-6856
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
NUP93	-6458
POLR2H	-6200
RPL8	-6101
RPLP1	-6018
NUP133	-5346
POLR2K	-4907
NUP42	-4045
HSP90AA1	-4016
NUP210	-3949
POLR2I	-3929
RPL28	-3873
TPR	-3744
FAU	-3618
UBA52	-3490
NUP85	-3427
POLR2B	-3384
AAAS	-3332
GRSF1	-2923
NUP62	-2410
NUP37	-2275
POM121C	-1710
RPL39L	-1661
RPS26	-1154
RANBP2	-1141
RPS27L	-496
POLR2C	-494
POM121	-142
NUP153	254
RPS4Y1	331
RPS9	1841
POLR2L	2016
NUP50	2638
POLR2G	4175
POLR2F	4256
RAE1	5007
POLR2E	5109
RPL3L	5150
POLR2J	5598
NUP98	5874
RPL26L1	6001
GTF2F2	6257
GTF2F1	6738
SEC13	7506
POLR2A	7852
NUP58	9577
DNAJC3	9831
NUP214	10131

---

Ribosomal scanning and start codon recognition

Ribosomal scanning and start codon recognition

	1014
set	Ribosomal scanning and start codon recognition
setSize	58
pANOVA	3.26e-14
s.dist	-0.576
p.adjustANOVA	1.2e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
EIF4A2	-9593
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
EIF4A2	-9593
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPS21	-8330
RPS18	-8321
RPS17	-8281
EIF3L	-8255
EIF4B	-8190
RPS28	-8083
RPS11	-7975
RPS19	-7806
EIF3H	-7091
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPSA	-6629
EIF3J	-6448
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
FAU	-3618
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
EIF5	2937
EIF4A1	5541
EIF4H	7768
EIF4G1	10506

---

Hyaluronan uptake and degradation

Hyaluronan uptake and degradation

	503
set	Hyaluronan uptake and degradation
setSize	12
pANOVA	0.000572
s.dist	0.574
p.adjustANOVA	0.00374

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC9A1	11350
HYAL2	11213
GUSB	11175
LYVE1	10724
CHP1	10038
CD44	9255
HYAL1	8371
HEXB	7695
STAB2	3499
HMMR	1858
HYAL3	-893
HEXA	-1967

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC9A1	11350
HYAL2	11213
GUSB	11175
LYVE1	10724
CHP1	10038
CD44	9255
HYAL1	8371
HEXB	7695
STAB2	3499
HMMR	1858
HYAL3	-893
HEXA	-1967

---

Unwinding of DNA

Unwinding of DNA

	1302
set	Unwinding of DNA
setSize	12
pANOVA	0.000597
s.dist	-0.572
p.adjustANOVA	0.00387

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM3	-9943
MCM7	-9325
MCM6	-8631
GINS4	-8275
MCM4	-7086
MCM2	-6880
MCM8	-5713
CDC45	-5132
GINS3	-3875
GINS2	-3476
MCM5	-2327
GINS1	4263

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM3	-9943
MCM7	-9325
MCM6	-8631
GINS4	-8275
MCM4	-7086
MCM2	-6880
MCM8	-5713
CDC45	-5132
GINS3	-3875
GINS2	-3476
MCM5	-2327
GINS1	4263

---

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	49
set	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
setSize	59
pANOVA	2.93e-14
s.dist	-0.572
p.adjustANOVA	1.11e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
EIF4A2	-9593
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPS3A	-9834
RPS27A	-9723
RPS6	-9699
RPS25	-9664
EIF4A2	-9593
RPS2	-9591
EIF3B	-9526
RPS20	-9413
RPS23	-9387
RPS3	-9298
RPS12	-9270
RPS27	-9175
RPS7	-9165
EIF3E	-9049
RPS5	-9042
RPS15A	-8883
RPS8	-8861
RPS13	-8724
RPS4X	-8648
RPS29	-8637
RPS16	-8579
RPS14	-8541
RPS10	-8494
EIF1AX	-8383
RPS21	-8330
RPS18	-8321
RPS17	-8281
EIF3L	-8255
EIF4B	-8190
RPS28	-8083
RPS11	-7975
RPS19	-7806
EIF3H	-7091
RPS24	-6818
EIF3M	-6817
RPS15	-6703
RPSA	-6629
EIF3J	-6448
EIF3F	-5200
EIF3D	-5158
EIF3C	-4716
FAU	-3618
PABPC1	-2991
EIF3G	-2746
EIF3I	-2580
EIF3K	-2369
EIF2S1	-1649
EIF3A	-1276
RPS26	-1154
RPS27L	-496
RPS4Y1	331
EIF2S2	554
EIF4E	1661
RPS9	1841
EIF2S3	2500
EIF4EBP1	2825
EIF4A1	5541
EIF4H	7768
EIF4G1	10506

---

NOTCH4 Activation and Transmission of Signal to the Nucleus

NOTCH4 Activation and Transmission of Signal to the Nucleus

	705
set	NOTCH4 Activation and Transmission of Signal to the Nucleus
setSize	10
pANOVA	0.00174
s.dist	0.572
p.adjustANOVA	0.00887

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCSTN	11452
PSEN1	10429
NOTCH4	10293
ADAM10	9992
APH1B	9474
JAG1	8240
PSENEN	7091
YWHAZ	5202
APH1A	2563
PSEN2	-6393

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCSTN	11452
PSEN1	10429
NOTCH4	10293
ADAM10	9992
APH1B	9474
JAG1	8240
PSENEN	7091
YWHAZ	5202
APH1A	2563
PSEN2	-6393

---

VLDLR internalisation and degradation

VLDLR internalisation and degradation

	1308
set	VLDLR internalisation and degradation
setSize	12
pANOVA	0.000642
s.dist	0.569
p.adjustANOVA	0.00406

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	11340
PCSK9	11027
CLTC	10304
AP2A2	10223
NR1H2	9521
AP2M1	8799
AP2S1	8045
CLTA	7164
VLDLR	6242
AP2B1	2910
NR1H3	954
MYLIP	-4888

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	11340
PCSK9	11027
CLTC	10304
AP2A2	10223
NR1H2	9521
AP2M1	8799
AP2S1	8045
CLTA	7164
VLDLR	6242
AP2B1	2910
NR1H3	954
MYLIP	-4888

---

PD-1 signaling

PD-1 signaling

	777
set	PD-1 signaling
setSize	28
pANOVA	2.24e-07
s.dist	-0.565
p.adjustANOVA	4.12e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
HLA-DQB2	-9656
LCK	-9556
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
HLA-DQA2	-8774
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD274	-7895
CD4	-6881
HLA-DQA1	-6389
PDCD1	-5516

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
HLA-DQB2	-9656
LCK	-9556
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
HLA-DQA2	-8774
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD274	-7895
CD4	-6881
HLA-DQA1	-6389
PDCD1	-5516
TRAV8-4	-4769
HLA-DQB1	-4459
HLA-DRB1	-334
PDCD1LG2	273
HLA-DRB5	748
PTPN11	6524
CSK	9400
PTPN6	10446

---

Platelet sensitization by LDL

Platelet sensitization by LDL

	831
set	Platelet sensitization by LDL
setSize	16
pANOVA	0.000104
s.dist	0.56
p.adjustANOVA	0.000947

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FGR	11323
MAPK14	11115
PTPN6	10446
PECAM1	10414
PPP2R5B	9913
PPP2R5A	9827
PLA2G4A	9803
LRP8	9649
PPP2CB	7451
PPP2CA	6806
PPP2R5D	6601
PTPN11	6524
PPP2R1A	5189
PPP2R1B	89
PPP2R5E	-2595
PPP2R5C	-5198

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FGR	11323
MAPK14	11115
PTPN6	10446
PECAM1	10414
PPP2R5B	9913
PPP2R5A	9827
PLA2G4A	9803
LRP8	9649
PPP2CB	7451
PPP2CA	6806
PPP2R5D	6601
PTPN11	6524
PPP2R1A	5189
PPP2R1B	89
PPP2R5E	-2595
PPP2R5C	-5198

---

DNA strand elongation

DNA strand elongation

	245
set	DNA strand elongation
setSize	32
pANOVA	4.6e-08
s.dist	-0.558
p.adjustANOVA	1.01e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
MCM3	-9943
POLA1	-9841
RPA1	-9799
LIG1	-9469
RFC3	-9405
MCM7	-9325
RPA3	-9220
PRIM1	-9166
RFC4	-8897
MCM6	-8631
GINS4	-8275
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
MCM4	-7086
MCM2	-6880
FEN1	-6485
DNA2	-6307

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
MCM3	-9943
POLA1	-9841
RPA1	-9799
LIG1	-9469
RFC3	-9405
MCM7	-9325
RPA3	-9220
PRIM1	-9166
RFC4	-8897
MCM6	-8631
GINS4	-8275
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
MCM4	-7086
MCM2	-6880
FEN1	-6485
DNA2	-6307
MCM8	-5713
CDC45	-5132
RFC1	-5080
RPA2	-4811
GINS3	-3875
GINS2	-3476
POLD1	-2573
MCM5	-2327
GINS1	4263
RFC2	5478
POLD4	9079
POLD3	10698

---

Processive synthesis on the lagging strand

Processive synthesis on the lagging strand

	858
set	Processive synthesis on the lagging strand
setSize	15
pANOVA	2e-04
s.dist	-0.555
p.adjustANOVA	0.00167

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RPA1	-9799
LIG1	-9469
RPA3	-9220
PRIM1	-9166
POLA2	-7950
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
RPA2	-4811
POLD1	-2573
POLD4	9079
POLD3	10698

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RPA1	-9799
LIG1	-9469
RPA3	-9220
PRIM1	-9166
POLA2	-7950
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
RPA2	-4811
POLD1	-2573
POLD4	9079
POLD3	10698

---

Lagging Strand Synthesis

Lagging Strand Synthesis

	590
set	Lagging Strand Synthesis
setSize	20
pANOVA	2.12e-05
s.dist	-0.549
p.adjustANOVA	0.000241

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RPA1	-9799
LIG1	-9469
RFC3	-9405
RPA3	-9220
PRIM1	-9166
RFC4	-8897
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
RFC1	-5080
RPA2	-4811
POLD1	-2573
RFC2	5478
POLD4	9079
POLD3	10698

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RPA1	-9799
LIG1	-9469
RFC3	-9405
RPA3	-9220
PRIM1	-9166
RFC4	-8897
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
RFC1	-5080
RPA2	-4811
POLD1	-2573
RFC2	5478
POLD4	9079
POLD3	10698

---

Gap junction trafficking

Gap junction trafficking

	435
set	Gap junction trafficking
setSize	13
pANOVA	0.00064
s.dist	0.547
p.adjustANOVA	0.00406

Top enriched genes

Top 20 genes

GeneID	Gene Rank
DAB2	10645
GJD3	10584
DNM2	10373
CLTC	10304
CLTCL1	9201
AP2M1	8799
CLTB	7968
CLTA	7164
DNM1	5998
GJC1	4969
GJB6	3533
GJC2	-694
MYO6	-3522

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
DAB2	10645
GJD3	10584
DNM2	10373
CLTC	10304
CLTCL1	9201
AP2M1	8799
CLTB	7968
CLTA	7164
DNM1	5998
GJC1	4969
GJB6	3533
GJC2	-694
MYO6	-3522

---

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

	344
set	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
setSize	11
pANOVA	0.00179
s.dist	0.544
p.adjustANOVA	0.00907

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LYN	10810
EPOR	10409
IRS2	9427
PIK3CG	9128
PIK3CB	9126
PIK3CD	8956
GAB1	8670
PIK3R5	7579
JAK2	4428
PIK3CA	2133
PIK3R1	-8831

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LYN	10810
EPOR	10409
IRS2	9427
PIK3CG	9128
PIK3CB	9126
PIK3CD	8956
GAB1	8670
PIK3R5	7579
JAK2	4428
PIK3CA	2133
PIK3R1	-8831

---

RHO GTPases Activate WASPs and WAVEs

RHO GTPases Activate WASPs and WAVEs

	887
set	RHO GTPases Activate WASPs and WAVEs
setSize	35
pANOVA	3.78e-08
s.dist	0.537
p.adjustANOVA	8.44e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
WASF1	11328
NCKAP1L	11304
MAPK1	11193
ARPC1A	10981
BTK	10849
WASF2	10807
ARPC1B	10781
WAS	10777
GRB2	10733
RAC1	10624
ACTB	10606
CYFIP1	10420
ARPC5	10102
MAPK3	9750
ACTG1	9678
ARPC4	9592
ABI1	9373
ARPC2	9016
ACTR2	8895
ACTR3	8873

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
WASF1	11328
NCKAP1L	11304
MAPK1	11193
ARPC1A	10981
BTK	10849
WASF2	10807
ARPC1B	10781
WAS	10777
GRB2	10733
RAC1	10624
ACTB	10606
CYFIP1	10420
ARPC5	10102
MAPK3	9750
ACTG1	9678
ARPC4	9592
ABI1	9373
ARPC2	9016
ACTR2	8895
ACTR3	8873
NCKAP1	8861
ARPC3	8726
WIPF2	8699
CDC42	8342
ABL1	6127
WASL	3297
WIPF1	3137
PTK2	388
CYFIP2	-775
WASF3	-1364
BAIAP2	-1877
BRK1	-2561
NCKIPSD	-3692
ABI2	-8174
NCK1	-8975

---

Advanced glycosylation endproduct receptor signaling

Advanced glycosylation endproduct receptor signaling

	60
set	Advanced glycosylation endproduct receptor signaling
setSize	12
pANOVA	0.00128
s.dist	0.537
p.adjustANOVA	0.00701

Top enriched genes

Top 20 genes

GeneID	Gene Rank
S100A12	11206
MAPK1	11193
MAPK3	9750
CAPZA1	9530
LGALS3	9180
DDOST	8464
CAPZA2	8225
PRKCSH	6831
APP	6245
AGER	4895
S100B	-1351
HMGB1	-6699

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
S100A12	11206
MAPK1	11193
MAPK3	9750
CAPZA1	9530
LGALS3	9180
DDOST	8464
CAPZA2	8225
PRKCSH	6831
APP	6245
AGER	4895
S100B	-1351
HMGB1	-6699

---

PCNA-Dependent Long Patch Base Excision Repair

PCNA-Dependent Long Patch Base Excision Repair

	775
set	PCNA-Dependent Long Patch Base Excision Repair
setSize	21
pANOVA	2.52e-05
s.dist	-0.531
p.adjustANOVA	0.000277

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APEX1	-10111
POLD2	-10054
RPA1	-9799
LIG1	-9469
RFC3	-9405
POLE3	-9287
RPA3	-9220
RFC4	-8897
POLB	-8449
POLE2	-7763
RFC5	-7574
PCNA	-7101
FEN1	-6485
RFC1	-5080
RPA2	-4811
POLE	-4081
POLD1	-2573
POLE4	-1856
RFC2	5478
POLD4	9079

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APEX1	-10111
POLD2	-10054
RPA1	-9799
LIG1	-9469
RFC3	-9405
POLE3	-9287
RPA3	-9220
RFC4	-8897
POLB	-8449
POLE2	-7763
RFC5	-7574
PCNA	-7101
FEN1	-6485
RFC1	-5080
RPA2	-4811
POLE	-4081
POLD1	-2573
POLE4	-1856
RFC2	5478
POLD4	9079
POLD3	10698

---

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

	799
set	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
setSize	13
pANOVA	0.000951
s.dist	0.529
p.adjustANOVA	0.00558

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAC1	10624
CRK	10387
ELMO2	10190
PXN	10135
RHOA	9401
PTK6	9263
DOCK1	7594
RASA1	6250
KRAS	6132
ELMO1	5455
NRAS	4907
ARHGAP35	-2201
HRAS	-5273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAC1	10624
CRK	10387
ELMO2	10190
PXN	10135
RHOA	9401
PTK6	9263
DOCK1	7594
RASA1	6250
KRAS	6132
ELMO1	5455
NRAS	4907
ARHGAP35	-2201
HRAS	-5273

---

Removal of the Flap Intermediate

Removal of the Flap Intermediate

	993
set	Removal of the Flap Intermediate
setSize	14
pANOVA	0.000635
s.dist	-0.527
p.adjustANOVA	0.00406

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RPA1	-9799
RPA3	-9220
PRIM1	-9166
POLA2	-7950
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
RPA2	-4811
POLD1	-2573
POLD4	9079
POLD3	10698

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RPA1	-9799
RPA3	-9220
PRIM1	-9166
POLA2	-7950
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
RPA2	-4811
POLD1	-2573
POLD4	9079
POLD3	10698

---

Erythrocytes take up carbon dioxide and release oxygen

Erythrocytes take up carbon dioxide and release oxygen

	343
set	Erythrocytes take up carbon dioxide and release oxygen
setSize	12
pANOVA	0.00158
s.dist	0.527
p.adjustANOVA	0.00815

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CYB5R1	11052
CA4	10997
CYB5R4	8995
CYB5R2	8743
CA1	8217
AQP1	7985
SLC4A1	7532
RHAG	7023
HBB	6697
HBA1	6237
CA2	42
CYB5RL	-7366

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CYB5R1	11052
CA4	10997
CYB5R4	8995
CYB5R2	8743
CA1	8217
AQP1	7985
SLC4A1	7532
RHAG	7023
HBB	6697
HBA1	6237
CA2	42
CYB5RL	-7366

---

O2/CO2 exchange in erythrocytes

O2/CO2 exchange in erythrocytes

	763
set	O2/CO2 exchange in erythrocytes
setSize	12
pANOVA	0.00158
s.dist	0.527
p.adjustANOVA	0.00815

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CYB5R1	11052
CA4	10997
CYB5R4	8995
CYB5R2	8743
CA1	8217
AQP1	7985
SLC4A1	7532
RHAG	7023
HBB	6697
HBA1	6237
CA2	42
CYB5RL	-7366

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CYB5R1	11052
CA4	10997
CYB5R4	8995
CYB5R2	8743
CA1	8217
AQP1	7985
SLC4A1	7532
RHAG	7023
HBB	6697
HBA1	6237
CA2	42
CYB5RL	-7366

---

SLBP independent Processing of Histone Pre-mRNAs

SLBP independent Processing of Histone Pre-mRNAs

	1034
set	SLBP independent Processing of Histone Pre-mRNAs
setSize	10
pANOVA	0.00433
s.dist	-0.521
p.adjustANOVA	0.0178

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP2	-9631
ZNF473	-9381
LSM11	-9085
SNRPF	-8687
SNRPE	-8564
SNRPD3	-6352
SNRPB	-4187
NCBP1	-942
SNRPG	560
LSM10	6472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP2	-9631
ZNF473	-9381
LSM11	-9085
SNRPF	-8687
SNRPE	-8564
SNRPD3	-6352
SNRPB	-4187
NCBP1	-942
SNRPG	560
LSM10	6472

---

WNT5A-dependent internalization of FZD4

WNT5A-dependent internalization of FZD4

	1322
set	WNT5A-dependent internalization of FZD4
setSize	13
pANOVA	0.00118
s.dist	0.519
p.adjustANOVA	0.0066

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	11340
ARRB2	10688
CLTC	10304
AP2A2	10223
AP2M1	8799
PRKCB	8577
AP2S1	8045
CLTB	7968
CLTA	7164
FZD4	3498
AP2B1	2910
PRKCA	-2408
DVL2	-5637

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	11340
ARRB2	10688
CLTC	10304
AP2A2	10223
AP2M1	8799
PRKCB	8577
AP2S1	8045
CLTB	7968
CLTA	7164
FZD4	3498
AP2B1	2910
PRKCA	-2408
DVL2	-5637

---

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

	997
set	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
setSize	24
pANOVA	1.17e-05
s.dist	-0.517
p.adjustANOVA	0.000147

Top enriched genes

Top 20 genes

GeneID	Gene Rank
APEX1	-10111
POLD2	-10054
RPA1	-9799
LIG1	-9469
RFC3	-9405
POLE3	-9287
RPA3	-9220
RFC4	-8897
POLB	-8449
PARP1	-8391
POLE2	-7763
RFC5	-7574
PCNA	-7101
FEN1	-6485
PARP2	-6040
RFC1	-5080
RPA2	-4811
POLE	-4081
POLD1	-2573
POLE4	-1856

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
APEX1	-10111
POLD2	-10054
RPA1	-9799
LIG1	-9469
RFC3	-9405
POLE3	-9287
RPA3	-9220
RFC4	-8897
POLB	-8449
PARP1	-8391
POLE2	-7763
RFC5	-7574
PCNA	-7101
FEN1	-6485
PARP2	-6040
RFC1	-5080
RPA2	-4811
POLE	-4081
POLD1	-2573
POLE4	-1856
PARG	2874
RFC2	5478
POLD4	9079
POLD3	10698

---

Retrograde neurotrophin signalling

Retrograde neurotrophin signalling

	1010
set	Retrograde neurotrophin signalling
setSize	12
pANOVA	0.00217
s.dist	0.511
p.adjustANOVA	0.0106

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	11340
DNM2	10373
CLTC	10304
AP2A2	10223
AP2M1	8799
AP2S1	8045
CLTA	7164
DNM1	5998
DNM3	3523
AP2B1	2910
DNAL4	-764
NTRK1	-3793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	11340
DNM2	10373
CLTC	10304
AP2A2	10223
AP2M1	8799
AP2S1	8045
CLTA	7164
DNM1	5998
DNM3	3523
AP2B1	2910
DNAL4	-764
NTRK1	-3793

---

Prolonged ERK activation events

Prolonged ERK activation events

	861
set	Prolonged ERK activation events
setSize	13
pANOVA	0.00151
s.dist	0.508
p.adjustANOVA	0.00799

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	11193
CRK	10387
MAP2K1	10148
MAPK3	9750
KIDINS220	9339
RAP1A	7335
MAP2K2	7222
CRKL	5250
RAPGEF1	5102
YWHAB	4721
BRAF	4367
FRS2	-1144
NTRK1	-3793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	11193
CRK	10387
MAP2K1	10148
MAPK3	9750
KIDINS220	9339
RAP1A	7335
MAP2K2	7222
CRKL	5250
RAPGEF1	5102
YWHAB	4721
BRAF	4367
FRS2	-1144
NTRK1	-3793

---

Purine ribonucleoside monophosphate biosynthesis

Purine ribonucleoside monophosphate biosynthesis

	869
set	Purine ribonucleoside monophosphate biosynthesis
setSize	10
pANOVA	0.00545
s.dist	-0.507
p.adjustANOVA	0.0219

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IMPDH2	-10126
ATIC	-10062
PPAT	-10019
PAICS	-9454
PFAS	-9385
ADSL	-6382
GMPS	-5196
LHPP	-3573
GART	4563
IMPDH1	11303

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IMPDH2	-10126
ATIC	-10062
PPAT	-10019
PAICS	-9454
PFAS	-9385
ADSL	-6382
GMPS	-5196
LHPP	-3573
GART	4563
IMPDH1	11303

---

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

	1033
set	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
setSize	11
pANOVA	0.00387
s.dist	-0.503
p.adjustANOVA	0.0164

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCBP2	-9631
ZNF473	-9381
LSM11	-9085
SNRPF	-8687
SNRPE	-8564
SNRPD3	-6352
SNRPB	-4187
SLBP	-2817
NCBP1	-942
SNRPG	560
LSM10	6472

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCBP2	-9631
ZNF473	-9381
LSM11	-9085
SNRPF	-8687
SNRPE	-8564
SNRPD3	-6352
SNRPB	-4187
SLBP	-2817
NCBP1	-942
SNRPG	560
LSM10	6472

---

Influenza Infection

Influenza Infection

	525
set	Influenza Infection
setSize	154
pANOVA	4.36e-27
s.dist	-0.503
p.adjustANOVA	2.28e-25

Top enriched genes

Top 20 genes

GeneID	Gene Rank
IPO5	-10129
NDC1	-10077
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
NUP35	-9726
RPS27A	-9723
RPS6	-9699
RPL14	-9698
NUP88	-9668
RPS25	-9664
RPL22	-9659
RPS2	-9591
SEH1L	-9574
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
IPO5	-10129
NDC1	-10077
RPL23A	-9979
RPL3	-9957
RPL5	-9881
RPS3A	-9834
RPL7	-9765
NUP35	-9726
RPS27A	-9723
RPS6	-9699
RPL14	-9698
NUP88	-9668
RPS25	-9664
RPL22	-9659
RPS2	-9591
SEH1L	-9574
RPL4	-9549
RPL21	-9511
RPL34	-9492
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
RPS3	-9298
RPL35A	-9291
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
RPL11	-9117
RPL17	-9116
RPL27A	-9048
RPS5	-9042
RPL10	-9031
KPNA5	-9017
RPL30	-8930
RPL10A	-8928
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
RPL31	-8769
RPS13	-8724
RPL26	-8706
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
RPS16	-8579
RPS14	-8541
RPS10	-8494
RAN	-8475
PARP1	-8391
RPL23	-8373
NUP43	-8368
NUP160	-8357
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
NUP107	-8285
RPS17	-8281
RPL22L1	-8202
RPL35	-8183
RPL15	-8169
RPS28	-8083
RPS11	-7975
RPL38	-7968
NUP188	-7953
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
RPL41	-7561
NUP205	-7516
RPL36	-7493
NUP54	-7131
NUP155	-7061
POLR2D	-6856
RPL37A	-6833
RPL9	-6821
RPS24	-6818
RPS15	-6703
RPL36AL	-6646
RPSA	-6629
NUP93	-6458
POLR2H	-6200
RPL8	-6101
RPLP1	-6018
SLC25A6	-5588
NUP133	-5346
ISG15	-5074
POLR2K	-4907
NUP42	-4045
CPSF4	-4025
HSP90AA1	-4016
NUP210	-3949
POLR2I	-3929
RPL28	-3873
TPR	-3744
FAU	-3618
UBA52	-3490
NUP85	-3427
POLR2B	-3384
AAAS	-3332
XPO1	-3214
GRSF1	-2923
KPNA2	-2535
NUP62	-2410
NUP37	-2275
KPNA3	-1964
PABPN1	-1789
POM121C	-1710
RPL39L	-1661
KPNA1	-1312
RPS26	-1154
RANBP2	-1141
RPS27L	-496
POLR2C	-494
POM121	-142
NUP153	254
RPS4Y1	331
RPS9	1841
POLR2L	2016
NUP50	2638
CANX	3332
POLR2G	4175
POLR2F	4256
RAE1	5007
POLR2E	5109
RPL3L	5150
TGFB1	5504
EIF2AK2	5594
POLR2J	5598
KPNB1	5604
KPNA4	5698
NUP98	5874
RPL26L1	6001
GTF2F2	6257
GTF2F1	6738
CLTA	7164
SEC13	7506
CALR	7713
POLR2A	7852
HSPA1A	9341
NUP58	9577
DNAJC3	9831
NUP214	10131
CLTC	10304

---

Signal transduction by L1

Signal transduction by L1

	1070
set	Signal transduction by L1
setSize	20
pANOVA	0.000105
s.dist	0.501
p.adjustANOVA	0.000953

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	11193
RAC1	10624
MAP2K1	10148
PAK1	10043
ITGA5	9848
MAPK3	9750
CSNK2A1	9040
ITGAV	7847
ITGA9	7807
ITGA2B	7387
CSNK2A2	7341
MAP2K2	7222
FGFR1	6607
NRP1	6221
CSNK2B	5876
ITGB3	2944
VAV2	2755
ITGB1	-3073
L1CAM	-3125
NCAM1	-5143

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	11193
RAC1	10624
MAP2K1	10148
PAK1	10043
ITGA5	9848
MAPK3	9750
CSNK2A1	9040
ITGAV	7847
ITGA9	7807
ITGA2B	7387
CSNK2A2	7341
MAP2K2	7222
FGFR1	6607
NRP1	6221
CSNK2B	5876
ITGB3	2944
VAV2	2755
ITGB1	-3073
L1CAM	-3125
NCAM1	-5143

---

Erythropoietin activates RAS

Erythropoietin activates RAS

	345
set	Erythropoietin activates RAS
setSize	13
pANOVA	0.00181
s.dist	0.5
p.adjustANOVA	0.00912

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LYN	10810
GRB2	10733
EPOR	10409
VAV1	10226
SHC1	9541
IRS2	9427
KRAS	6132
CRKL	5250
RAPGEF1	5102
NRAS	4907
JAK2	4428
SOS1	-2983
HRAS	-5273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LYN	10810
GRB2	10733
EPOR	10409
VAV1	10226
SHC1	9541
IRS2	9427
KRAS	6132
CRKL	5250
RAPGEF1	5102
NRAS	4907
JAK2	4428
SOS1	-2983
HRAS	-5273

---

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Synthesis of Leukotrienes (LT) and Eoxins (EX)

	1164
set	Synthesis of Leukotrienes (LT) and Eoxins (EX)
setSize	15
pANOVA	0.000851
s.dist	0.497
p.adjustANOVA	0.00508

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GGT1	11459
ALOX5	11178
PTGR1	10862
CYP4F8	10561
LTA4H	10541
ALOX5AP	9860
MAPKAPK2	8852
CYP4F3	7797
ABCC1	5410
GGT5	5204
CYP4F22	4727
DPEP2	2213
DPEP3	1876
LTC4S	-624
ALOX15	-9484

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GGT1	11459
ALOX5	11178
PTGR1	10862
CYP4F8	10561
LTA4H	10541
ALOX5AP	9860
MAPKAPK2	8852
CYP4F3	7797
ABCC1	5410
GGT5	5204
CYP4F22	4727
DPEP2	2213
DPEP3	1876
LTC4S	-624
ALOX15	-9484

---

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

	33
set	Activation of ATR in response to replication stress
setSize	37
pANOVA	2.01e-07
s.dist	-0.494
p.adjustANOVA	3.75e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MCM3	-9943
RAD1	-9896
RPA1	-9799
RFC3	-9405
MCM7	-9325
RPA3	-9220
DBF4	-8907
RFC4	-8897
MCM6	-8631
ORC5	-8539
RAD17	-8493
ORC2	-8256
ORC3	-7889
RFC5	-7574
RAD9A	-7462
MCM4	-7086
MCM2	-6880
ORC4	-6267
CHEK1	-6143
MCM8	-5713

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MCM3	-9943
RAD1	-9896
RPA1	-9799
RFC3	-9405
MCM7	-9325
RPA3	-9220
DBF4	-8907
RFC4	-8897
MCM6	-8631
ORC5	-8539
RAD17	-8493
ORC2	-8256
ORC3	-7889
RFC5	-7574
RAD9A	-7462
MCM4	-7086
MCM2	-6880
ORC4	-6267
CHEK1	-6143
MCM8	-5713
ATR	-5340
CDC45	-5132
RPA2	-4811
MCM10	-4587
CDC7	-4493
CDK2	-3614
ATRIP	-3603
ORC1	-2973
MCM5	-2327
CDC6	-1597
CDC25A	317
CLSPN	1968
HUS1	4236
ORC6	5337
RFC2	5478
CDC25C	5800
RAD9B	6597

---

Telomere C-strand (Lagging Strand) Synthesis

Telomere C-strand (Lagging Strand) Synthesis

	1217
set	Telomere C-strand (Lagging Strand) Synthesis
setSize	34
pANOVA	6.34e-07
s.dist	-0.493
p.adjustANOVA	1.04e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
STN1	-9859
POLA1	-9841
RPA1	-9799
CHTF18	-9602
WRN	-9501
LIG1	-9469
RFC3	-9405
RPA3	-9220
PRIM1	-9166
RFC4	-8897
CTC1	-8852
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
DSCC1	-5837
ACD	-5673

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
STN1	-9859
POLA1	-9841
RPA1	-9799
CHTF18	-9602
WRN	-9501
LIG1	-9469
RFC3	-9405
RPA3	-9220
PRIM1	-9166
RFC4	-8897
CTC1	-8852
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
FEN1	-6485
DNA2	-6307
DSCC1	-5837
ACD	-5673
BLM	-5151
RFC1	-5080
RPA2	-4811
POT1	-4708
TERF2	-4421
TERF1	-2831
POLD1	-2573
CHTF8	-124
TEN1	624
TERF2IP	4065
RFC2	5478
TINF2	8502
POLD4	9079
POLD3	10698

---

Phosphorylation of CD3 and TCR zeta chains

Phosphorylation of CD3 and TCR zeta chains

	819
set	Phosphorylation of CD3 and TCR zeta chains
setSize	27
pANOVA	1.07e-05
s.dist	-0.489
p.adjustANOVA	0.000138

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
HLA-DQB2	-9656
LCK	-9556
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
HLA-DQA2	-8774
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD4	-6881
HLA-DQA1	-6389
TRAV8-4	-4769
HLA-DQB1	-4459

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
HLA-DQB2	-9656
LCK	-9556
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
HLA-DQA2	-8774
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD4	-6881
HLA-DQA1	-6389
TRAV8-4	-4769
HLA-DQB1	-4459
HLA-DRB1	-334
HLA-DRB5	748
PAG1	6054
PTPN22	6966
PTPRC	8021
CSK	9400
PTPRJ	10340

---

RHO GTPases activate CIT

RHO GTPases activate CIT

	888
set	RHO GTPases activate CIT
setSize	18
pANOVA	0.000325
s.dist	0.489
p.adjustANOVA	0.00245

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAC1	10624
MYL6	10185
DLG4	9813
RHOA	9401
MYH9	9224
MYH10	8632
PPP1R12B	8489
RHOB	7921
PPP1R12A	7801
PPP1CB	6745
KIF14	5707
MYL12B	5703
RHOC	4639
CIT	3097
PRC1	2399
MYL9	1931
MYH11	-2243
CDKN1B	-3127

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAC1	10624
MYL6	10185
DLG4	9813
RHOA	9401
MYH9	9224
MYH10	8632
PPP1R12B	8489
RHOB	7921
PPP1R12A	7801
PPP1CB	6745
KIF14	5707
MYL12B	5703
RHOC	4639
CIT	3097
PRC1	2399
MYL9	1931
MYH11	-2243
CDKN1B	-3127

---

Generation of second messenger molecules

Generation of second messenger molecules

	443
set	Generation of second messenger molecules
setSize	38
pANOVA	2.64e-07
s.dist	-0.482
p.adjustANOVA	4.67e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
ITK	-9674
HLA-DQB2	-9656
EVL	-9560
LCK	-9556
LAT	-9470
PLCG1	-9412
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
NCK1	-8975
HLA-DQA2	-8774
ZAP70	-8755
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
TRBV12-3	-9971
TRAC	-9703
ITK	-9674
HLA-DQB2	-9656
EVL	-9560
LCK	-9556
LAT	-9470
PLCG1	-9412
TRBC1	-9303
TRAV29DV5	-9278
CD3E	-9249
TRAV19	-9248
HLA-DRA	-9006
NCK1	-8975
HLA-DQA2	-8774
ZAP70	-8755
CD247	-8741
HLA-DPB1	-8397
TRBV7-9	-8303
CD3D	-8297
HLA-DPA1	-8217
CD3G	-8111
CD4	-6881
HLA-DQA1	-6389
PAK3	-5908
TRAV8-4	-4769
HLA-DQB1	-4459
GRAP2	-2088
CD101	-1089
HLA-DRB1	-334
HLA-DRB5	748
ENAH	3578
LCP2	3759
PAK2	9042
PAK1	10043
PLCG2	10244
VASP	10286
WAS	10777

---

Pre-NOTCH Processing in Golgi

Pre-NOTCH Processing in Golgi

	845
set	Pre-NOTCH Processing in Golgi
setSize	18
pANOVA	0.000408
s.dist	0.481
p.adjustANOVA	0.00289

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NOTCH3	11420
FURIN	10905
ATP2A2	10359
NOTCH4	10293
ST3GAL4	10218
RAB6A	9958
NOTCH1	9499
NOTCH2	8400
SEL1L	7883
B4GALT1	7763
TMED2	5345
RFNG	4095
ATP2A1	3981
ATP2A3	3651
ST3GAL6	3223
LFNG	1213
ST3GAL3	-5250
MFNG	-7604

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NOTCH3	11420
FURIN	10905
ATP2A2	10359
NOTCH4	10293
ST3GAL4	10218
RAB6A	9958
NOTCH1	9499
NOTCH2	8400
SEL1L	7883
B4GALT1	7763
TMED2	5345
RFNG	4095
ATP2A1	3981
ATP2A3	3651
ST3GAL6	3223
LFNG	1213
ST3GAL3	-5250
MFNG	-7604

---

Heme degradation

Heme degradation

	493
set	Heme degradation
setSize	10
pANOVA	0.00889
s.dist	0.478
p.adjustANOVA	0.032

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GUSB	11175
HMOX1	11030
SLCO2B1	10681
BLVRB	9359
ALB	8630
BLVRA	7999
ABCC1	5410
ABCG2	1372
ABCC2	1314
HMOX2	-8794

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GUSB	11175
HMOX1	11030
SLCO2B1	10681
BLVRB	9359
ALB	8630
BLVRA	7999
ABCC1	5410
ABCG2	1372
ABCC2	1314
HMOX2	-8794

---

BBSome-mediated cargo-targeting to cilium

BBSome-mediated cargo-targeting to cilium

	98
set	BBSome-mediated cargo-targeting to cilium
setSize	22
pANOVA	0.000114
s.dist	-0.475
p.adjustANOVA	0.00102

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CCT2	-10024
LZTFL1	-8558
BBS9	-8390
BBS2	-8123
BBS5	-7994
MKKS	-7647
BBS1	-7348
ARL6	-7121
CCT3	-6877
CCT4	-6795
BBIP1	-5342
SSTR3	-5020
TCP1	-4240
BBS4	-3211
CCT8	-2751
BBS10	-2726
BBS12	-1657
BBS7	-934
MCHR1	-651
RAB3IP	-569

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CCT2	-10024
LZTFL1	-8558
BBS9	-8390
BBS2	-8123
BBS5	-7994
MKKS	-7647
BBS1	-7348
ARL6	-7121
CCT3	-6877
CCT4	-6795
BBIP1	-5342
SSTR3	-5020
TCP1	-4240
BBS4	-3211
CCT8	-2751
BBS10	-2726
BBS12	-1657
BBS7	-934
MCHR1	-651
RAB3IP	-569
CCT5	3205
TTC8	4167

---

Golgi Cisternae Pericentriolar Stack Reorganization

Golgi Cisternae Pericentriolar Stack Reorganization

	466
set	Golgi Cisternae Pericentriolar Stack Reorganization
setSize	14
pANOVA	0.00208
s.dist	0.475
p.adjustANOVA	0.0103

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	11193
RAB1B	10055
RAB1A	9971
MAPK3	9750
GORASP1	9633
RAB2A	9581
GOLGA2	9412
CCNB2	7285
PLK1	5400
BLZF1	3737
USO1	2424
CCNB1	735
CDK1	-2593
GORASP2	-5545

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	11193
RAB1B	10055
RAB1A	9971
MAPK3	9750
GORASP1	9633
RAB2A	9581
GOLGA2	9412
CCNB2	7285
PLK1	5400
BLZF1	3737
USO1	2424
CCNB1	735
CDK1	-2593
GORASP2	-5545

---

Diseases associated with the TLR signaling cascade

Diseases associated with the TLR signaling cascade

	287
set	Diseases associated with the TLR signaling cascade
setSize	23
pANOVA	7.99e-05
s.dist	0.475
p.adjustANOVA	0.000755

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYD88	11331
TLR5	11191
CD36	10947
BTK	10849
TLR2	10535
UNC93B1	10526
TLR1	10059
TLR4	9549
CD14	9466
IKBKG	9441
LY96	9322
TLR6	9070
TICAM1	8878
TIRAP	8858
CHUK	8723
NFKBIA	5457
NFKB1	2860
IKBKB	1759
RELA	-204
NFKB2	-3527

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYD88	11331
TLR5	11191
CD36	10947
BTK	10849
TLR2	10535
UNC93B1	10526
TLR1	10059
TLR4	9549
CD14	9466
IKBKG	9441
LY96	9322
TLR6	9070
TICAM1	8878
TIRAP	8858
CHUK	8723
NFKBIA	5457
NFKB1	2860
IKBKB	1759
RELA	-204
NFKB2	-3527
TLR10	-7067
TLR3	-7411
TRAF3	-7539

---

Diseases of Immune System

Diseases of Immune System

	289
set	Diseases of Immune System
setSize	23
pANOVA	7.99e-05
s.dist	0.475
p.adjustANOVA	0.000755

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MYD88	11331
TLR5	11191
CD36	10947
BTK	10849
TLR2	10535
UNC93B1	10526
TLR1	10059
TLR4	9549
CD14	9466
IKBKG	9441
LY96	9322
TLR6	9070
TICAM1	8878
TIRAP	8858
CHUK	8723
NFKBIA	5457
NFKB1	2860
IKBKB	1759
RELA	-204
NFKB2	-3527

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MYD88	11331
TLR5	11191
CD36	10947
BTK	10849
TLR2	10535
UNC93B1	10526
TLR1	10059
TLR4	9549
CD14	9466
IKBKG	9441
LY96	9322
TLR6	9070
TICAM1	8878
TIRAP	8858
CHUK	8723
NFKBIA	5457
NFKB1	2860
IKBKB	1759
RELA	-204
NFKB2	-3527
TLR10	-7067
TLR3	-7411
TRAF3	-7539

---

RHO GTPases activate IQGAPs

RHO GTPases activate IQGAPs

	889
set	RHO GTPases activate IQGAPs
setSize	11
pANOVA	0.0068
s.dist	0.471
p.adjustANOVA	0.0258

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CTNNA1	11326
CLIP1	10646
RAC1	10624
IQGAP1	10037
CTNNB1	9670
IQGAP2	8437
CDC42	8342
IQGAP3	1051
CDH1	-307
CALM1	-1245
MEN1	-5364

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CTNNA1	11326
CLIP1	10646
RAC1	10624
IQGAP1	10037
CTNNB1	9670
IQGAP2	8437
CDC42	8342
IQGAP3	1051
CDH1	-307
CALM1	-1245
MEN1	-5364

---

EPHB-mediated forward signaling

EPHB-mediated forward signaling

	323
set	EPHB-mediated forward signaling
setSize	32
pANOVA	4.14e-06
s.dist	0.47
p.adjustANOVA	5.69e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARPC1A	10981
LYN	10810
ARPC1B	10781
ITSN1	10737
RAC1	10624
ACTB	10606
ARPC5	10102
PAK1	10043
CFL1	9794
LIMK2	9689
ACTG1	9678
ARPC4	9592
RHOA	9401
ARPC2	9016
ACTR2	8895
ACTR3	8873
ARPC3	8726
ROCK1	8695
CDC42	8342
LIMK1	8062

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARPC1A	10981
LYN	10810
ARPC1B	10781
ITSN1	10737
RAC1	10624
ACTB	10606
ARPC5	10102
PAK1	10043
CFL1	9794
LIMK2	9689
ACTG1	9678
ARPC4	9592
RHOA	9401
ARPC2	9016
ACTR2	8895
ACTR3	8873
ARPC3	8726
ROCK1	8695
CDC42	8342
LIMK1	8062
ROCK2	6611
RASA1	6250
WASL	3297
ARHGEF28	2384
SDC2	2325
PTK2	388
YES1	-2846
TIAM1	-3517
FYN	-5211
HRAS	-5273
SRC	-6396
KALRN	-8077

---

RHO GTPases Activate NADPH Oxidases

RHO GTPases Activate NADPH Oxidases

	885
set	RHO GTPases Activate NADPH Oxidases
setSize	21
pANOVA	0.000204
s.dist	0.468
p.adjustANOVA	0.00168

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	11193
S100A8	11184
PRKCD	11168
MAPK14	11115
NCF4	10813
NCF2	10793
RAC1	10624
S100A9	10613
CYBA	10173
MAPK3	9750
CYBB	9660
PRKCB	8577
RAC2	8237
NCF1	7245
PIN1	577
PIK3C3	-1718
PIK3R4	-2097
PRKCA	-2408
MAPK11	-4641
NOXA1	-4914

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	11193
S100A8	11184
PRKCD	11168
MAPK14	11115
NCF4	10813
NCF2	10793
RAC1	10624
S100A9	10613
CYBA	10173
MAPK3	9750
CYBB	9660
PRKCB	8577
RAC2	8237
NCF1	7245
PIN1	577
PIK3C3	-1718
PIK3R4	-2097
PRKCA	-2408
MAPK11	-4641
NOXA1	-4914
PRKCZ	-6016

---

Telomere C-strand synthesis initiation

Telomere C-strand synthesis initiation

	1218
set	Telomere C-strand synthesis initiation
setSize	13
pANOVA	0.0035
s.dist	-0.468
p.adjustANOVA	0.0151

Top enriched genes

Top 20 genes

GeneID	Gene Rank
STN1	-9859
POLA1	-9841
PRIM1	-9166
CTC1	-8852
POLA2	-7950
PRIM2	-7112
ACD	-5673
POT1	-4708
TERF2	-4421
TERF1	-2831
TEN1	624
TERF2IP	4065
TINF2	8502

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
STN1	-9859
POLA1	-9841
PRIM1	-9166
CTC1	-8852
POLA2	-7950
PRIM2	-7112
ACD	-5673
POT1	-4708
TERF2	-4421
TERF1	-2831
TEN1	624
TERF2IP	4065
TINF2	8502

---

Sema4D in semaphorin signaling

Sema4D in semaphorin signaling

	1060
set	Sema4D in semaphorin signaling
setSize	22
pANOVA	0.000152
s.dist	0.466
p.adjustANOVA	0.00132

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARHGEF11	11412
RRAS	10835
RAC1	10624
MYL6	10185
LIMK2	9689
RHOA	9401
MYH9	9224
ROCK1	8695
MYH10	8632
LIMK1	8062
RHOB	7921
ROCK2	6611
MYL12B	5703
PLXNB1	5405
RHOC	4639
ARHGEF12	4165
RND1	3716
MYL9	1931
SEMA4D	-1019
ARHGAP35	-2201

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARHGEF11	11412
RRAS	10835
RAC1	10624
MYL6	10185
LIMK2	9689
RHOA	9401
MYH9	9224
ROCK1	8695
MYH10	8632
LIMK1	8062
RHOB	7921
ROCK2	6611
MYL12B	5703
PLXNB1	5405
RHOC	4639
ARHGEF12	4165
RND1	3716
MYL9	1931
SEMA4D	-1019
ARHGAP35	-2201
MYH11	-2243
ERBB2	-6142

---

COPI-independent Golgi-to-ER retrograde traffic

COPI-independent Golgi-to-ER retrograde traffic

	131
set	COPI-independent Golgi-to-ER retrograde traffic
setSize	33
pANOVA	5.41e-06
s.dist	0.457
p.adjustANOVA	7.29e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GALNT2	10885
DCTN4	10682
DCTN2	10412
ACTR1A	10310
RAB6A	9958
PLA2G4A	9803
BICD2	9707
CAPZB	9575
DCTN1	9558
CAPZA1	9530
DYNC1LI1	8276
CAPZA2	8225
AGPAT3	7932
PAFAH1B1	7857
DYNC1LI2	7644
DCTN6	7540
RAB18	7038
DYNC1I2	6705
DCTN3	6625
RAB3GAP2	6599

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GALNT2	10885
DCTN4	10682
DCTN2	10412
ACTR1A	10310
RAB6A	9958
PLA2G4A	9803
BICD2	9707
CAPZB	9575
DCTN1	9558
CAPZA1	9530
DYNC1LI1	8276
CAPZA2	8225
AGPAT3	7932
PAFAH1B1	7857
DYNC1LI2	7644
DCTN6	7540
RAB18	7038
DYNC1I2	6705
DCTN3	6625
RAB3GAP2	6599
GALNT1	6495
PAFAH1B2	5996
ACTR10	5886
RAB3GAP1	5167
DYNC1I1	2879
DYNC1H1	1705
DYNLL1	1530
DCTN5	297
RAB6B	-1849
BICD1	-2303
PAFAH1B3	-4044
DYNLL2	-4904
PLA2G6	-7168

---

Cargo concentration in the ER

Cargo concentration in the ER

	145
set	Cargo concentration in the ER
setSize	30
pANOVA	1.48e-05
s.dist	0.457
p.adjustANOVA	0.000179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
F5	11434
SERPINA1	11407
TGFA	10983
SEC24D	10803
PREB	10364
CTSZ	9943
LMAN2	9480
SEC24A	9414
CTSC	9276
SEC24C	8993
STX5	8547
MIA2	8200
F8	8026
COL7A1	7971
SEC24B	7352
SEC23A	7129
SAR1B	6893
SEC22B	6272
GOSR2	5986
TMED2	5345

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
F5	11434
SERPINA1	11407
TGFA	10983
SEC24D	10803
PREB	10364
CTSZ	9943
LMAN2	9480
SEC24A	9414
CTSC	9276
SEC24C	8993
STX5	8547
MIA2	8200
F8	8026
COL7A1	7971
SEC24B	7352
SEC23A	7129
SAR1B	6893
SEC22B	6272
GOSR2	5986
TMED2	5345
MCFD2	5134
CD59	4252
CNIH2	4186
AREG	2386
LMAN2L	1586
CNIH1	-2698
MIA3	-3686
TMED10	-4413
CNIH3	-4435
LMAN1	-8522

---

Sema4D induced cell migration and growth-cone collapse

Sema4D induced cell migration and growth-cone collapse

	1061
set	Sema4D induced cell migration and growth-cone collapse
setSize	19
pANOVA	0.000582
s.dist	0.456
p.adjustANOVA	0.00379

Top enriched genes

Top 20 genes

GeneID	Gene Rank
ARHGEF11	11412
MYL6	10185
LIMK2	9689
RHOA	9401
MYH9	9224
ROCK1	8695
MYH10	8632
LIMK1	8062
RHOB	7921
ROCK2	6611
MYL12B	5703
PLXNB1	5405
RHOC	4639
ARHGEF12	4165
RND1	3716
MYL9	1931
SEMA4D	-1019
MYH11	-2243
ERBB2	-6142

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
ARHGEF11	11412
MYL6	10185
LIMK2	9689
RHOA	9401
MYH9	9224
ROCK1	8695
MYH10	8632
LIMK1	8062
RHOB	7921
ROCK2	6611
MYL12B	5703
PLXNB1	5405
RHOC	4639
ARHGEF12	4165
RND1	3716
MYL9	1931
SEMA4D	-1019
MYH11	-2243
ERBB2	-6142

---

Leading Strand Synthesis

Leading Strand Synthesis

	594
set	Leading Strand Synthesis
setSize	14
pANOVA	0.00329
s.dist	-0.454
p.adjustANOVA	0.0145

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RFC3	-9405
PRIM1	-9166
RFC4	-8897
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
RFC1	-5080
POLD1	-2573
RFC2	5478
POLD4	9079
POLD3	10698

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RFC3	-9405
PRIM1	-9166
RFC4	-8897
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
RFC1	-5080
POLD1	-2573
RFC2	5478
POLD4	9079
POLD3	10698

---

Polymerase switching

Polymerase switching

	833
set	Polymerase switching
setSize	14
pANOVA	0.00329
s.dist	-0.454
p.adjustANOVA	0.0145

Top enriched genes

Top 20 genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RFC3	-9405
PRIM1	-9166
RFC4	-8897
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
RFC1	-5080
POLD1	-2573
RFC2	5478
POLD4	9079
POLD3	10698

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
POLD2	-10054
POLA1	-9841
RFC3	-9405
PRIM1	-9166
RFC4	-8897
POLA2	-7950
RFC5	-7574
PRIM2	-7112
PCNA	-7101
RFC1	-5080
POLD1	-2573
RFC2	5478
POLD4	9079
POLD3	10698

---

Signaling by Erythropoietin

Signaling by Erythropoietin

	1083
set	Signaling by Erythropoietin
setSize	24
pANOVA	0.000126
s.dist	0.452
p.adjustANOVA	0.00113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
LYN	10810
GRB2	10733
EPOR	10409
PLCG2	10244
VAV1	10226
SHC1	9541
IRS2	9427
PIK3CG	9128
PIK3CB	9126
PIK3CD	8956
STAT5B	8742
GAB1	8670
STAT5A	7833
PIK3R5	7579
KRAS	6132
CRKL	5250
RAPGEF1	5102
NRAS	4907
JAK2	4428
PIK3CA	2133

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
LYN	10810
GRB2	10733
EPOR	10409
PLCG2	10244
VAV1	10226
SHC1	9541
IRS2	9427
PIK3CG	9128
PIK3CB	9126
PIK3CD	8956
STAT5B	8742
GAB1	8670
STAT5A	7833
PIK3R5	7579
KRAS	6132
CRKL	5250
RAPGEF1	5102
NRAS	4907
JAK2	4428
PIK3CA	2133
SOS1	-2983
HRAS	-5273
PIK3R1	-8831
PLCG1	-9412

---

GPVI-mediated activation cascade

GPVI-mediated activation cascade

	429
set	GPVI-mediated activation cascade
setSize	31
pANOVA	1.49e-05
s.dist	0.449
p.adjustANOVA	0.000179

Top enriched genes

Top 20 genes

GeneID	Gene Rank
FCER1G	11216
LYN	10810
RHOG	10635
RAC1	10624
PTPN6	10446
SYK	10256
PLCG2	10244
VAV1	10226
PIK3R6	10025
RHOA	9401
PIK3CG	9128
PIK3CB	9126
PDPK1	8710
VAV3	8413
CLEC1B	8373
CDC42	8342
RAC2	8237
RHOB	7921
PIK3R5	7579
PTPN11	6524

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
FCER1G	11216
LYN	10810
RHOG	10635
RAC1	10624
PTPN6	10446
SYK	10256
PLCG2	10244
VAV1	10226
PIK3R6	10025
RHOA	9401
PIK3CG	9128
PIK3CB	9126
PDPK1	8710
VAV3	8413
CLEC1B	8373
CDC42	8342
RAC2	8237
RHOB	7921
PIK3R5	7579
PTPN11	6524
PIK3R2	6511
GP6	5660
LCP2	3759
VAV2	2755
PIK3R3	2676
PIK3CA	2133
FYN	-5211
PRKCZ	-6016
PIK3R1	-8831
LAT	-9470
LCK	-9556

---

Neutrophil degranulation

Neutrophil degranulation

	734
set	Neutrophil degranulation
setSize	458
pANOVA	3.16e-61
s.dist	0.449
p.adjustANOVA	4.3e-58

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC11A1	11464
NCSTN	11452
DOK3	11443
P2RX1	11442
LILRB2	11437
HK3	11430
OSCAR	11425
IDH1	11418
SIRPA	11414
GNS	11410
SERPINA1	11407
CR1	11401
DNASE1L1	11385
SIGLEC9	11381
QSOX1	11369
CD63	11355
MCEMP1	11349
FGR	11323
HP	11312
NCKAP1L	11304

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC11A1	11464
NCSTN	11452
DOK3	11443
P2RX1	11442
LILRB2	11437
HK3	11430
OSCAR	11425
IDH1	11418
SIRPA	11414
GNS	11410
SERPINA1	11407
CR1	11401
DNASE1L1	11385
SIGLEC9	11381
QSOX1	11369
CD63	11355
MCEMP1	11349
FGR	11323
HP	11312
NCKAP1L	11304
IMPDH1	11303
CTSD	11297
C3AR1	11294
ATP6V0A1	11283
LAIR1	11276
ITGAM	11269
UNC13D	11266
CTSB	11250
ITGAX	11231
ANPEP	11227
FPR1	11221
FCER1G	11216
TIMP2	11214
S100A12	11206
MAPK1	11193
RNASE2	11192
S100A8	11184
ALOX5	11178
GUSB	11175
PRKCD	11168
TCIRG1	11138
TRPM2	11134
PGAM1	11128
PLAC8	11120
MAPK14	11115
PLD1	11091
NEU1	11082
SERPINB1	11081
ACAA1	11076
CD177	11068
ALDH3B1	11063
C5AR1	11061
MMP25	11057
AGPAT2	11054
PLEKHO2	11053
ADGRG3	11019
VNN1	11000
GCA	10999
ATP6V0C	10995
VAT1	10971
BRI3	10962
RAB10	10956
PYGL	10952
MGAM	10950
CD36	10947
CD93	10937
MOSPD2	10933
CEACAM3	10932
MMP9	10920
CD55	10914
S100A11	10910
NFAM1	10890
FPR2	10883
GYG1	10873
ALDOA	10868
ITGB2	10861
CDA	10859
GM2A	10846
CTSA	10842
GRN	10837
CKAP4	10819
CRISPLD2	10814
ASAH1	10796
ATP11A	10791
LRG1	10785
CYB5R3	10775
TSPAN14	10759
NBEAL2	10743
RETN	10732
SLC2A3	10714
ANXA2	10704
QPCT	10700
SLC15A4	10684
RAB3D	10677
RAB31	10661
BST1	10647
RHOG	10635
GPR84	10632
RAC1	10624
S100A9	10613
CYSTM1	10605
GLA	10595
TOM1	10594
CAPN1	10570
GSN	10558
TNFAIP6	10555
CD68	10546
LTA4H	10541
PYCARD	10540
TLR2	10535
PKM	10523
IGF2R	10494
PLAUR	10490
FCGR2A	10470
ALAD	10449
PTPN6	10446
LILRB3	10433
PSEN1	10429
CYFIP1	10420
PECAM1	10414
CLEC4D	10398
PGM2	10380
DNAJC5	10371
CD300A	10362
PTPRJ	10340
COTL1	10333
CD53	10308
ACLY	10268
PADI2	10252
AP2A2	10223
FCAR	10219
GLB1	10217
TMBIM1	10197
PTAFR	10188
AMPD3	10183
CYBA	10173
DOCK2	10155
NAPRT	10133
RAB7A	10115
CAT	10103
ARPC5	10102
FTL	10101
TNFRSF1B	10079
ARG1	10061
ARL8A	10056
ARSB	10041
IQGAP1	10037
ADAM10	9992
CPPED1	9991
ATP6V1D	9982
SELL	9974
RAB6A	9958
SDCBP	9947
CTSZ	9943
CAP1	9934
DNAJC13	9921
S100P	9918
RAB5C	9864
MGST1	9847
DNAJC3	9831
DBNL	9815
BIN2	9720
LAMP1	9712
ARHGAP9	9702
CD58	9688
TOLLIP	9682
HSPA6	9675
CYBB	9660
TYROBP	9637
VAPA	9635
RAB24	9634
RAB27A	9628
AP1M1	9595
CSTB	9479
CD14	9466
GMFG	9443
RHOA	9401
CAB39	9379
DERA	9344
HSPA1A	9341
CXCR1	9335
VPS35L	9320
CTSC	9276
LAMTOR1	9265
CANT1	9259
CD44	9255
SIGLEC5	9235
LGALS3	9180
SNAP29	9157
CNN2	9140
TRAPPC1	9087
CEACAM1	9052
GALNS	9046
LAMP2	9034
PDAP1	9011
IST1	8994
STK10	8992
CMTM6	8960
ADAM8	8938
ADGRE5	8937
ACTR2	8895
PSAP	8894
MNDA	8892
CFP	8875
STK11IP	8872
HPSE	8832
APAF1	8822
HSPA1B	8806
MMP8	8706
ROCK1	8695
CREG1	8692
GAA	8625
MVP	8603
HEBP2	8559
ATP11B	8523
PRCP	8518
CLEC5A	8487
SLCO4C1	8486
DDOST	8464
PSMB7	8460
ARSA	8456
RAB4B	8449
TUBB4B	8440
IQGAP2	8437
KCMF1	8403
OSTF1	8338
SURF4	8306
DYNC1LI1	8276
PDXK	8267
RAB5B	8258
PSMD1	8184
PSMD2	8139
PNP	8043
PTPRC	8021
LAMTOR2	8006
COPB1	7997
STOM	7990
RNASET2	7961
FCN1	7954
FABP5	7903
ITGAV	7847
VCP	7804
PSMD11	7775
B4GALT1	7763
LPCAT1	7696
HEXB	7695
MANBA	7689
OLFM4	7638
RAP2C	7598
FAF2	7588
SNAP23	7530
RAP1A	7335
PSMD6	7307
YPEL5	7288
PGM1	7238
GGH	7233
COMMD9	7156
SIRPB1	7136
DIAPH1	7128
GPI	7117
CXCL1	7072
RAB18	7038
TMEM30A	7030
RAP1B	6962
GDI2	6949
CD33	6932
DYNLT1	6926
FTH1	6883
C6orf120	6840
PSMD12	6820
CXCR2	6720
METTL7A	6718
HBB	6697
UBR4	6594
CTSS	6504
FUCA1	6469
KCNAB2	6369
PIGR	6337
RAB3A	6284
VCL	6193
LRMP	6184
ATG7	6082
FUCA2	6028
PAFAH1B2	5996
NDUFC2	5943
ACTR10	5886
CSNK2B	5876
MAN2B1	5768
STBD1	5663
SIGLEC14	5662
SERPINB10	5629
KPNB1	5604
RAB14	5469
LAMTOR3	5383
SERPINB6	5280
ATP8B4	5252
SLC44A2	5180
DGAT1	5173
PRDX6	5085
SRP14	5022
NHLRC3	5010
CTSH	4985
APEH	4945
ATP6AP2	4915
PGLYRP1	4910
NRAS	4907
PTPRN2	4854
ERP44	4818
GLIPR1	4675
ARMC8	4598
PSMC2	4543
NFASC	4356
MAGT1	4339
PSMD3	4297
TICAM2	4262
CD59	4252
TARM1	3952
RAP2B	3915
PLAU	3907
PSMD13	3766
ITGAL	3647
ANO6	3404
NPC2	3326
DEGS1	3135
CPNE3	2985
HLA-C	2969
NFKB1	2860
FOLR3	2736
FRK	2672
AOC1	2506
CLEC12A	2330
LCN2	2300
CLEC4C	2219
CDK13	2118
PSMD7	2084
ORM1	2075
GHDC	1853
XRCC5	1832
CST3	1747
DYNC1H1	1705
DDX3X	1692
PTX3	1567
DYNLL1	1530
CRISP3	1416
FCGR3B	1391
ADGRE3	1240
HUWE1	1218
CRACR2A	1215
PSMD14	941
PSMC3	916
SYNGR1	852
MLEC	796
MME	695
ORM2	565
CFD	461
GSDMD	370
AGL	316
STING1	94
GOLGA7	14
PGRMC1	-59
HLA-B	-98
VAMP8	-139
HVCN1	-250
ENPP4	-308
LRRC7	-340
RNASE3	-371
PYGB	-418
FRMPD3	-550
DSP	-573
HGSNAT	-737
GSTP1	-759
BST2	-782
NME2	-791
PRDX4	-834
RAB37	-1057
LYZ	-1067
A1BG	-1468
CPNE1	-1632
TMEM179B	-1671
TUBB	-1675
TCN1	-1708
CHIT1	-1890
PPBP	-1960
TXNDC5	-2141
COMMD3	-2657
JUP	-2668
HLA-H	-2741
CCT8	-2751
PSMA2	-2823
SVIP	-3052
SLPI	-3392
C3	-3394
RAB44	-3423
PFKL	-3512
PSMB1	-3610
HSP90AA1	-4016
RAB9B	-4177
PTPRB	-4321
ILF2	-4378
LTF	-4464
EPX	-4781
HRNR	-5086
PA2G4	-5255
KRT1	-5265
DSN1	-5307
BPI	-5410
PTGES2	-5466
ALDOC	-5613
CHI3L1	-5761
ACTR1B	-5952
HLA-A	-5985
DPP7	-6012
FGL2	-6015
ORMDL3	-6182
SLC27A2	-6278
EEF2	-6279
PPIE	-6341
SLC2A5	-6479
PPIA	-6498
TMC6	-6551
HMGB1	-6699
ABCA13	-6934
B2M	-6943
MS4A3	-7001
CAND1	-7058
MIF	-7102
SCAMP1	-7313
PSMA5	-7476
CEACAM8	-7546
APRT	-7580
TBC1D10C	-7608
OLR1	-7621
AGA	-7674
DEFA1	-7680
DEFA4	-7723
TMEM63A	-7978
XRCC6	-8146
CEP290	-8156
MPO	-8263
CEACAM6	-8277
ATAD3B	-8354
ELANE	-8371
CAMP	-8417
RHOF	-8679
HMOX2	-8794
HSPA8	-9129
NIT2	-9152
CD47	-9164
HSP90AB1	-9172
ATP8A1	-9218
PRTN3	-9350
AZU1	-9380
SPTAN1	-9461
CTSG	-9503
DSC1	-9630
EEF1A1	-9751
CCT2	-10024
IMPDH2	-10126

---

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

	981
set	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
setSize	11
pANOVA	0.0102
s.dist	0.447
p.adjustANOVA	0.0363

Top enriched genes

Top 20 genes

GeneID	Gene Rank
PFKFB4	11413
PRKACA	11363
PFKFB3	11033
PFKFB2	10694
PPP2CB	7451
PPP2CA	6806
PPP2R5D	6601
PPP2R1A	5189
PPP2R1B	89
PFKFB1	-427
PRKACB	-9863

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
PFKFB4	11413
PRKACA	11363
PFKFB3	11033
PFKFB2	10694
PPP2CB	7451
PPP2CA	6806
PPP2R5D	6601
PPP2R1A	5189
PPP2R1B	89
PFKFB1	-427
PRKACB	-9863

---

RHO GTPases activate PAKs

RHO GTPases activate PAKs

	891
set	RHO GTPases activate PAKs
setSize	20
pANOVA	0.000538
s.dist	0.447
p.adjustANOVA	0.00359

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RAC1	10624
MYL6	10185
PAK1	10043
MYH9	9224
PAK2	9042
MYH10	8632
PPP1R12B	8489
CDC42	8342
FLNA	8318
LIMK1	8062
PPP1R12A	7801
PPP1CB	6745
MYL12B	5703
NF2	4139
MYL9	1931
MYLK	1267
CTTN	514
CALM1	-1245
MYH11	-2243
PAK3	-5908

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RAC1	10624
MYL6	10185
PAK1	10043
MYH9	9224
PAK2	9042
MYH10	8632
PPP1R12B	8489
CDC42	8342
FLNA	8318
LIMK1	8062
PPP1R12A	7801
PPP1CB	6745
MYL12B	5703
NF2	4139
MYL9	1931
MYLK	1267
CTTN	514
CALM1	-1245
MYH11	-2243
PAK3	-5908

---

Hyaluronan metabolism

Hyaluronan metabolism

	502
set	Hyaluronan metabolism
setSize	15
pANOVA	0.00274
s.dist	0.447
p.adjustANOVA	0.0124

Top enriched genes

Top 20 genes

GeneID	Gene Rank
SLC9A1	11350
HYAL2	11213
GUSB	11175
LYVE1	10724
CHP1	10038
CD44	9255
HYAL1	8371
HEXB	7695
STAB2	3499
HAS3	3339
HMMR	1858
ABCC5	1588
HYAL3	-893
HEXA	-1967
CEMIP	-5033

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
SLC9A1	11350
HYAL2	11213
GUSB	11175
LYVE1	10724
CHP1	10038
CD44	9255
HYAL1	8371
HEXB	7695
STAB2	3499
HAS3	3339
HMMR	1858
ABCC5	1588
HYAL3	-893
HEXA	-1967
CEMIP	-5033

---

Translation

Translation

	1266
set	Translation
setSize	295
pANOVA	9.42e-40
s.dist	-0.446
p.adjustANOVA	2.14e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
MRPS6	-9838
RPS3A	-9834
RPL7	-9765
EEF1A1	-9751
NARS2	-9738
EEF1B2	-9732
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
LARS1	-9637
EIF4A2	-9593
RPS2	-9591
FARS2	-9569
RPL4	-9549
EIF3B	-9526

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPL23A	-9979
RPL3	-9957
RPL5	-9881
MRPS6	-9838
RPS3A	-9834
RPL7	-9765
EEF1A1	-9751
NARS2	-9738
EEF1B2	-9732
RPS27A	-9723
RPS6	-9699
RPL14	-9698
RPS25	-9664
RPL22	-9659
LARS1	-9637
EIF4A2	-9593
RPS2	-9591
FARS2	-9569
RPL4	-9549
EIF3B	-9526
RPL21	-9511
RPL34	-9492
GFM1	-9467
MRPS33	-9440
RPS20	-9413
RPL13A	-9402
RPS23	-9387
RPL32	-9345
RPL6	-9309
MRPL50	-9302
RPS3	-9298
EEF1G	-9293
RPL35A	-9291
N6AMT1	-9282
MRPS25	-9279
RPS12	-9270
RPLP0	-9227
RPL12	-9177
RPS27	-9175
RPS7	-9165
RPLP2	-9163
MRPS27	-9147
RPL11	-9117
RPL17	-9116
EIF3E	-9049
RPL27A	-9048
RPS5	-9042
RPL10	-9031
IARS1	-8999
RPL30	-8930
RPL10A	-8928
MRPS9	-8917
RPL36A	-8909
RPL24	-8901
RPL18A	-8896
RPS15A	-8883
RPL18	-8863
RPS8	-8861
MRPL48	-8859
RPL31	-8769
RPS13	-8724
RPL26	-8706
MRPL24	-8692
RPS4X	-8648
RPS29	-8637
RPL39	-8635
RPL29	-8621
FARSB	-8580
RPS16	-8579
EARS2	-8562
RPS14	-8541
RPS10	-8494
MRPL46	-8479
EIF1AX	-8383
KARS1	-8380
RPL23	-8373
RPL19	-8338
RPS21	-8330
RPS18	-8321
RPL7A	-8286
RPS17	-8281
MRPS30	-8262
EIF3L	-8255
AARS2	-8248
RPL22L1	-8202
EIF4B	-8190
RPL35	-8183
RPL15	-8169
MRPS18B	-8125
RPS28	-8083
MRPL17	-8047
GSPT2	-7995
MRPL32	-7992
AIMP1	-7990
RPS11	-7975
RPL38	-7968
MARS2	-7955
MRPL39	-7936
SARS2	-7925
RPL37	-7861
RPL27	-7810
RPS19	-7806
RPL13	-7671
WARS2	-7615
MRPL1	-7594
RPL41	-7561
SRPRB	-7520
MRPL38	-7496
RPL36	-7493
MRPS2	-7237
MRPL42	-7224
MRPL9	-7188
EIF3H	-7091
DAP3	-7087
MRPL45	-6990
DARS1	-6939
MRPS17	-6909
EIF5B	-6867
RPL37A	-6833
HARS1	-6831
RPL9	-6821
RPS24	-6818
EIF3M	-6817
AARS1	-6785
MRPL14	-6728
MRPS14	-6718
RPS15	-6703
MRPS7	-6677
EIF2B3	-6649
RPL36AL	-6646
RPSA	-6629
PTCD3	-6500
TRAM1	-6480
EIF3J	-6448
EPRS1	-6350
MRPS21	-6319
EEF2	-6279
LARS2	-6268
MRPS28	-6255
RPL8	-6101
TSFM	-6082
SEC11C	-6046
SARS1	-6044
RPLP1	-6018
PPA1	-5970
MRPL35	-5957
MRPL3	-5916
EEF1A1P5	-5877
EEF1D	-5664
MRPS12	-5654
MRPL49	-5619
MRPL54	-5616
EIF2B5	-5580
MRRF	-5487
MRPL11	-5474
MRPS26	-5430
SEC61A2	-5333
EIF3F	-5200
EIF3D	-5158
MT-RNR1	-5094
MRPL57	-5039
YARS2	-5018
MRPL34	-4765
EIF3C	-4716
MRPL43	-4449
MRPL27	-4262
MRPS23	-4230
MRPL19	-4123
VARS1	-4083
MRPL58	-3985
RARS1	-3944
RPL28	-3873
MRPS31	-3868
MRPL12	-3819
RARS2	-3810
QARS1	-3758
WARS1	-3717
VARS2	-3646
FAU	-3618
SRP72	-3562
MRPL55	-3524
UBA52	-3490
MRPL41	-3438
SRP9	-3414
AIMP2	-3343
MRPS35	-3315
MRPL18	-3314
EEF1A2	-3246
SEC61G	-3152
MTIF2	-3020
PABPC1	-2991
MRPL40	-2981
MRPL15	-2975
SSR2	-2917
GADD45GIP1	-2813
EIF3G	-2746
MRPS10	-2725
EEF1E1	-2716
EIF3I	-2580
MRPL21	-2473
PPA2	-2453
MRPL2	-2449
MRPL30	-2421
MRPS22	-2388
EIF3K	-2369
TRMT112	-2296
EIF2B1	-2228
MRPS34	-2208
MRPS18C	-2145
MRPL47	-2119
GSPT1	-2025
MRPL4	-1924
MRPL16	-1832
SPCS1	-1700
RPL39L	-1661
EIF2S1	-1649
MRPL20	-1647
IARS2	-1595
ERAL1	-1389
EIF3A	-1276
NARS1	-1189
RPS26	-1154
SPCS2	-977
MRPS15	-924
SRP19	-625
FARSA	-514
RPS27L	-496
MRPS36	-492
MRPL22	-462
MT-RNR2	-408
MRPL13	-237
MRPL37	177
MTIF3	221
RPS4Y1	331
MRPS16	350
EIF2S2	554
SRP68	787
TARS2	801
PARS2	910
MRPS24	1048
SSR1	1143
SSR4	1294
MRPS18A	1407
GFM2	1540
MRPL36	1646
EIF4E	1661
YARS1	1707
TARS1	1786
OXA1L	1825
RPS9	1841
MRPL44	1847
SPCS3	1967
MRPS11	2087
MRPS5	2484
EIF2S3	2500
SSR3	2510
MRPL51	2595
MRPL33	2637
HARS2	2776
EIF4EBP1	2825
EIF5	2937
DARS2	2971
MT-TV	3363
TUFM	3457
CHCHD1	3643
MRPL52	4004
MRPL10	4156
EIF2B4	4294
SEC61B	4322
MTFMT	4587
MRPL23	4865
APEH	4945
SRP14	5022
RPL3L	5150
MTRF1L	5386
EIF4A1	5541
AURKAIP1	5758
RPL26L1	6001
MRPL53	6626
SEC11A	6634
GARS1	6727
ETF1	6835
RPN1	7151
MARS1	7358
SEC61A1	7486
EIF2B2	7498
EIF4H	7768
SRP54	7912
SRPRA	8301
DDOST	8464
CARS2	8664
RPN2	8874
MRPL28	9785
EIF4G1	10506
CARS1	10656

---

Frs2-mediated activation

Frs2-mediated activation

	399
set	Frs2-mediated activation
setSize	11
pANOVA	0.0105
s.dist	0.445
p.adjustANOVA	0.0369

Top enriched genes

Top 20 genes

GeneID	Gene Rank
MAPK1	11193
MAP2K1	10148
MAPK3	9750
RAP1A	7335
MAP2K2	7222
CRKL	5250
RAPGEF1	5102
YWHAB	4721
BRAF	4367
FRS2	-1144
NTRK1	-3793

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
MAPK1	11193
MAP2K1	10148
MAPK3	9750
RAP1A	7335
MAP2K2	7222
CRKL	5250
RAPGEF1	5102
YWHAB	4721
BRAF	4367
FRS2	-1144
NTRK1	-3793

---

Regulated proteolysis of p75NTR

Regulated proteolysis of p75NTR

	944
set	Regulated proteolysis of p75NTR
setSize	11
pANOVA	0.0109
s.dist	0.443
p.adjustANOVA	0.0378

Top enriched genes

Top 20 genes

GeneID	Gene Rank
NCSTN	11452
ADAM17	10964
PSEN1	10429
APH1B	9474
PSENEN	7091
NGFR	7009
TRAF6	4673
NFKB1	2860
APH1A	2563
RELA	-204
PSEN2	-6393

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
NCSTN	11452
ADAM17	10964
PSEN1	10429
APH1B	9474
PSENEN	7091
NGFR	7009
TRAF6	4673
NFKB1	2860
APH1A	2563
RELA	-204
PSEN2	-6393

---

Translesion synthesis by REV1

Translesion synthesis by REV1

	1273
set	Translesion synthesis by REV1
setSize	16
pANOVA	0.00221
s.dist	-0.442
p.adjustANOVA	0.0107

Top enriched genes

Top 20 genes

GeneID	Gene Rank
RPA1	-9799
RPS27A	-9723
RFC3	-9405
RPA3	-9220
RFC4	-8897
RFC5	-7574
REV1	-7478
PCNA	-7101
REV3L	-5347
RFC1	-5080
RPA2	-4811
UBA52	-3490
UBB	1026
RFC2	5478
UBC	6135
MAD2L2	9324

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
RPA1	-9799
RPS27A	-9723
RFC3	-9405
RPA3	-9220
RFC4	-8897
RFC5	-7574
REV1	-7478
PCNA	-7101
REV3L	-5347
RFC1	-5080
RPA2	-4811
UBA52	-3490
UBB	1026
RFC2	5478
UBC	6135
MAD2L2	9324

---

Trafficking of GluR2-containing AMPA receptors

Trafficking of GluR2-containing AMPA receptors

	1246
set	Trafficking of GluR2-containing AMPA receptors
setSize	12
pANOVA	0.00828
s.dist	0.44
p.adjustANOVA	0.0301

Top enriched genes

Top 20 genes

GeneID	Gene Rank
AP2A1	11340
AP2A2	10223
NSF	9870
AP2M1	8799
PRKCB	8577
AP2S1	8045
PICK1	6735
GRIA4	5498
TSPAN7	5060
AP2B1	2910
PRKCA	-2408
GRIP1	-9719

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
AP2A1	11340
AP2A2	10223
NSF	9870
AP2M1	8799
PRKCB	8577
AP2S1	8045
PICK1	6735
GRIA4	5498
TSPAN7	5060
AP2B1	2910
PRKCA	-2408
GRIP1	-9719

---

AKT phosphorylates targets in the cytosol

AKT phosphorylates targets in the cytosol

	8
set	AKT phosphorylates targets in the cytosol
setSize	14
pANOVA	0.00465
s.dist	0.437
p.adjustANOVA	0.0189

Top enriched genes

Top 20 genes

GeneID	Gene Rank
CASP9	11186
GSK3A	9979
CHUK	8723
AKT1S1	8410
BAD	7263
GSK3B	7147
MKRN1	6583
AKT1	6498
MDM2	6043
CDKN1A	5537
AKT2	5502
TSC2	4311
CDKN1B	-3127
AKT3	-8810

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
CASP9	11186
GSK3A	9979
CHUK	8723
AKT1S1	8410
BAD	7263
GSK3B	7147
MKRN1	6583
AKT1	6498
MDM2	6043
CDKN1A	5537
AKT2	5502
TSC2	4311
CDKN1B	-3127
AKT3	-8810

---

Mucopolysaccharidoses

Mucopolysaccharidoses

	681
set	Mucopolysaccharidoses
setSize	11
pANOVA	0.0122
s.dist	0.437
p.adjustANOVA	0.0412

Top enriched genes

Top 20 genes

GeneID	Gene Rank
GNS	11410
GUSB	11175
GLB1	10217
ARSB	10041
GALNS	9046
HYAL1	8371
SGSH	2887
NAGLU	1714
IDS	1338
HGSNAT	-737
IDUA	-6370

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
GNS	11410
GUSB	11175
GLB1	10217
ARSB	10041
GALNS	9046
HYAL1	8371
SGSH	2887
NAGLU	1714
IDS	1338
HGSNAT	-737
IDUA	-6370

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.2 (2020-06-22)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.7.1
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.7.1
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.1.0               GGally_2.0.0               
##  [3] beeswarm_0.2.3              gtools_3.8.2               
##  [5] echarts4r_0.3.2             mitch_1.0.6                
##  [7] MASS_7.3-52                 fgsea_1.14.0               
##  [9] gplots_3.0.3                DESeq2_1.28.1              
## [11] SummarizedExperiment_1.18.1 DelayedArray_0.14.0        
## [13] matrixStats_0.56.0          Biobase_2.48.0             
## [15] GenomicRanges_1.40.0        GenomeInfoDb_1.24.2        
## [17] IRanges_2.22.2              S4Vectors_0.26.1           
## [19] BiocGenerics_0.34.0         reshape2_1.4.4             
## [21] forcats_0.5.0               stringr_1.4.0              
## [23] dplyr_1.0.0                 purrr_0.3.4                
## [25] readr_1.3.1                 tidyr_1.1.0                
## [27] tibble_3.0.1                ggplot2_3.3.2              
## [29] tidyverse_1.3.0            
## 
## loaded via a namespace (and not attached):
##  [1] colorspace_1.4-1       ellipsis_0.3.1         rprojroot_1.3-2       
##  [4] XVector_0.28.0         fs_1.4.2               rstudioapi_0.11       
##  [7] bit64_0.9-7            AnnotationDbi_1.50.1   fansi_0.4.1           
## [10] lubridate_1.7.9        xml2_1.3.2             splines_4.0.2         
## [13] geneplotter_1.66.0     knitr_1.29             jsonlite_1.7.0        
## [16] broom_0.5.6            annotate_1.66.0        dbplyr_1.4.4          
## [19] shiny_1.5.0            compiler_4.0.2         httr_1.4.1            
## [22] backports_1.1.8        assertthat_0.2.1       Matrix_1.2-18         
## [25] fastmap_1.0.1          cli_2.0.2              later_1.1.0.1         
## [28] htmltools_0.5.0        tools_4.0.2            gtable_0.3.0          
## [31] glue_1.4.1             GenomeInfoDbData_1.2.3 fastmatch_1.1-0       
## [34] Rcpp_1.0.4.6           cellranger_1.1.0       vctrs_0.3.1           
## [37] gdata_2.18.0           nlme_3.1-148           xfun_0.15             
## [40] testthat_2.3.2         rvest_0.3.5            mime_0.9              
## [43] lifecycle_0.2.0        XML_3.99-0.3           zlibbioc_1.34.0       
## [46] scales_1.1.1           hms_0.5.3              promises_1.1.1        
## [49] RColorBrewer_1.1-2     yaml_2.2.1             memoise_1.1.0         
## [52] gridExtra_2.3          reshape_0.8.8          stringi_1.4.6         
## [55] RSQLite_2.2.0          highr_0.8              genefilter_1.70.0     
## [58] desc_1.2.0             caTools_1.18.0         BiocParallel_1.22.0   
## [61] rlang_0.4.6            pkgconfig_2.0.3        bitops_1.0-6          
## [64] evaluate_0.14          lattice_0.20-41        htmlwidgets_1.5.1     
## [67] bit_1.1-15.2           tidyselect_1.1.0       plyr_1.8.6            
## [70] magrittr_1.5           R6_2.4.1               generics_0.0.2        
## [73] DBI_1.1.0              pillar_1.4.4           haven_2.3.1           
## [76] withr_2.2.0            survival_3.2-3         RCurl_1.98-1.2        
## [79] modelr_0.1.8           crayon_1.3.4           KernSmooth_2.23-17    
## [82] rmarkdown_2.3          locfit_1.5-9.4         grid_4.0.2            
## [85] readxl_1.3.1           data.table_1.12.8      blob_1.2.1            
## [88] reprex_0.3.0           digest_0.6.25          pbmcapply_1.5.0       
## [91] xtable_1.8-4           httpuv_1.5.4           munsell_0.5.0

END of report