Mitch Report

date generated: 2020-10-07

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##             clus_0    clus_1     clus_2     clus_3     clus_4
## ADRA2A    306.4644        NA  -9.384027 -70.310973  -51.68441
## GAL       306.4644 -31.39679 -55.193734  -1.320342  -66.06683
## BAIAP2L2  306.4644 -39.46899 -53.821741         NA  -43.30152
## LYAR      306.4644 -63.85702         NA         NA -151.79865
## ATP5F1E  -286.0978        NA         NA  85.149859         NA
## CD63     -286.0978        NA -14.442367 121.889583   57.78314

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genes_in_profile	1528
duplicated_genes_present	0
num_profile_genes_in_sets	1035
num_profile_genes_not_in_sets	493

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: ReactomePathways.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	2408
num_genesets_excluded	2024
num_genesets_included	384

Genes by sector
	clus_0	clus_1	clus_2	clus_3	clus_4	Count
1	1	-1	-1	-1	-1	1
2	1	-1	1	-1	-1	5
3	-1	1	-1	1	-1	3
4	-1	-1	-1	-1	1	3
5	-1	0	0	-1	1	1
6	-1	-1	-1	0	1	1
7	-1	1	-1	1	1	1

Number of significant gene sets (FDR<0.05)= 9

Gene sets by sector

Gene sets by sector
	s.clus_0	s.clus_1	s.clus_2	s.clus_3	s.clus_4	Count
1	-1	-1	1	-1	-1	1
2	1	-1	1	-1	-1	6
3	1	1	1	-1	-1	1
4	-1	1	-1	-1	1	1

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 10 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.clus_0	s.clus_1	s.clus_2	s.clus_3	s.clus_4	p.clus_0	p.clus_1	p.clus_2	p.clus_3	p.clus_4
B-WICH complex positively regulates rRNA expression	8	5.07e-06	2.59e-05	0.274	0.1110	-0.0101	0.0365	-0.0309	-0.2460	0.913	0.000207	0.044	0.358	0.400
Developmental Biology	157	5.07e-06	2.59e-05	0.181	-0.0591	0.1380	-0.0638	-0.0597	0.0492	0.913	0.000207	0.044	0.358	0.400
Epigenetic regulation of gene expression	14	5.07e-06	2.59e-05	0.282	0.1050	-0.0327	0.0890	-0.0309	-0.2420	0.913	0.000207	0.044	0.358	0.400
Gene expression (Transcription)	145	5.07e-06	2.59e-05	0.207	0.0746	-0.0303	0.0951	-0.0527	-0.1570	0.913	0.000207	0.044	0.358	0.400
Generic Transcription Pathway	110	5.07e-06	2.59e-05	0.114	-0.0057	-0.0263	0.0758	-0.0362	-0.0728	0.913	0.000207	0.044	0.358	0.400
Positive epigenetic regulation of rRNA expression	11	5.07e-06	2.59e-05	0.252	0.1110	-0.0101	0.0890	-0.0309	-0.2050	0.913	0.000207	0.044	0.358	0.400
RNA Polymerase II Transcription	130	5.07e-06	2.59e-05	0.162	0.0482	-0.0308	0.0829	-0.0381	-0.1210	0.913	0.000207	0.044	0.358	0.400
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	9	5.07e-06	2.59e-05	0.349	0.0698	-0.0405	0.1330	-0.1310	-0.2840	0.913	0.000207	0.044	0.358	0.400
Transcriptional regulation of granulopoiesis	7	5.07e-06	2.59e-05	0.464	0.3040	0.0154	0.2530	-0.1310	-0.2030	0.913	0.000207	0.044	0.358	0.400
IRE1alpha activates chaperones	9	8.07e-02	3.09e-01	0.229	0.0730	0.0441	0.1010	-0.0970	0.1600	0.222	0.205000	0.415	0.249	0.863

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.clus_0	s.clus_1	s.clus_2	s.clus_3	s.clus_4	p.clus_0	p.clus_1	p.clus_2	p.clus_3	p.clus_4
B-WICH complex positively regulates rRNA expression	8	5.07e-06	2.59e-05	0.2740	0.11100	-0.010100	0.036500	-0.030900	-0.24600	0.9130	0.000207	0.044	0.3580	0.40000
Developmental Biology	157	5.07e-06	2.59e-05	0.1810	-0.05910	0.138000	-0.063800	-0.059700	0.04920	0.9130	0.000207	0.044	0.3580	0.40000
Epigenetic regulation of gene expression	14	5.07e-06	2.59e-05	0.2820	0.10500	-0.032700	0.089000	-0.030900	-0.24200	0.9130	0.000207	0.044	0.3580	0.40000
Gene expression (Transcription)	145	5.07e-06	2.59e-05	0.2070	0.07460	-0.030300	0.095100	-0.052700	-0.15700	0.9130	0.000207	0.044	0.3580	0.40000
Generic Transcription Pathway	110	5.07e-06	2.59e-05	0.1140	-0.00570	-0.026300	0.075800	-0.036200	-0.07280	0.9130	0.000207	0.044	0.3580	0.40000
Positive epigenetic regulation of rRNA expression	11	5.07e-06	2.59e-05	0.2520	0.11100	-0.010100	0.089000	-0.030900	-0.20500	0.9130	0.000207	0.044	0.3580	0.40000
RNA Polymerase II Transcription	130	5.07e-06	2.59e-05	0.1620	0.04820	-0.030800	0.082900	-0.038100	-0.12100	0.9130	0.000207	0.044	0.3580	0.40000
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	9	5.07e-06	2.59e-05	0.3490	0.06980	-0.040500	0.133000	-0.131000	-0.28400	0.9130	0.000207	0.044	0.3580	0.40000
Transcriptional regulation of granulopoiesis	7	5.07e-06	2.59e-05	0.4640	0.30400	0.015400	0.253000	-0.131000	-0.20300	0.9130	0.000207	0.044	0.3580	0.40000
IRE1alpha activates chaperones	9	8.07e-02	3.09e-01	0.2290	0.07300	0.044100	0.101000	-0.097000	0.16000	0.2220	0.205000	0.415	0.2490	0.86300
Unfolded Protein Response (UPR)	15	8.07e-02	3.09e-01	0.1890	0.06060	0.008810	0.141000	-0.097000	0.05110	0.2220	0.205000	0.415	0.2490	0.86300
XBP1(S) activates chaperone genes	9	8.07e-02	3.09e-01	0.2290	0.07300	0.044100	0.101000	-0.097000	0.16000	0.2220	0.205000	0.415	0.2490	0.86300
Class A/1 (Rhodopsin-like receptors)	5	1.26e-01	3.42e-01	0.3050	0.20000	0.098100	-0.118000	-0.146000	0.09070	0.0890	0.979000	0.148	0.7950	0.65700
G alpha (i) signalling events	22	1.26e-01	3.42e-01	0.2890	-0.09680	0.079600	-0.090900	-0.081900	0.23000	0.0890	0.979000	0.148	0.7950	0.65700
GPCR downstream signalling	30	1.26e-01	3.42e-01	0.2980	-0.10900	0.041500	-0.101000	-0.011800	0.25400	0.0890	0.979000	0.148	0.7950	0.65700
GPCR ligand binding	11	1.26e-01	3.42e-01	0.3300	0.03010	0.098100	-0.152000	-0.073100	0.26400	0.0890	0.979000	0.148	0.7950	0.65700
Signaling by GPCR	31	1.26e-01	3.42e-01	0.2950	-0.10900	0.041500	-0.101000	-0.011800	0.25100	0.0890	0.979000	0.148	0.7950	0.65700
Cellular responses to external stimuli	112	2.32e-01	5.86e-01	0.2060	0.07990	0.097100	0.003180	-0.094400	-0.13400	0.1390	0.760000	0.163	0.5590	0.00453
Metabolism of proteins	292	2.42e-01	5.86e-01	0.1040	0.01310	0.062700	0.010500	-0.044000	-0.06900	0.4290	0.859000	0.868	0.3250	0.10200
Post-translational protein modification	153	4.00e-01	7.85e-01	0.0546	-0.03860	-0.012300	0.034800	-0.010200	0.00535	0.0544	0.485000	0.691	0.7560	0.07020
Post-translational protein phosphorylation	25	4.00e-01	7.85e-01	0.5160	-0.29600	0.140000	-0.058100	0.023800	0.39400	0.0544	0.485000	0.691	0.7560	0.07020
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	28	4.00e-01	7.85e-01	0.5310	-0.28700	0.140000	-0.070400	-0.007020	0.41900	0.0544	0.485000	0.691	0.7560	0.07020
Cellular Senescence	21	4.86e-01	7.85e-01	0.2270	0.07180	-0.073100	0.047500	-0.127000	-0.15000	0.2420	0.784000	0.884	0.7630	0.17200
Senescence-Associated Secretory Phenotype (SASP)	13	4.86e-01	7.85e-01	0.1750	-0.03060	-0.054500	0.011400	-0.137000	-0.08790	0.2420	0.784000	0.884	0.7630	0.17200
Signal Transduction	235	4.96e-01	7.85e-01	0.1350	-0.05540	-0.012500	0.002420	-0.020800	0.12100	0.8490	0.305000	0.135	0.3090	0.86000
Cellular responses to stress	111	5.59e-01	7.85e-01	0.2180	0.08660	0.096700	0.009190	-0.095300	-0.14600	0.2080	0.775000	0.430	0.6070	0.03960
NR1H2 and NR1H3-mediated signaling	6	6.04e-01	7.85e-01	0.2760	-0.17600	0.194000	0.035100	-0.044100	0.06340	0.1610	0.145000	0.574	0.0863	0.83900
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	5	6.04e-01	7.85e-01	0.3640	-0.22500	0.194000	0.035100	-0.044100	0.20300	0.1610	0.145000	0.574	0.0863	0.83900
SLC-mediated transmembrane transport	21	6.04e-01	7.85e-01	0.2440	-0.05370	0.194000	-0.109000	0.066400	0.05090	0.1610	0.145000	0.574	0.0863	0.83900
Signaling by Nuclear Receptors	46	6.04e-01	7.85e-01	0.0823	-0.02670	0.028000	0.010800	-0.036300	0.06190	0.1610	0.145000	0.574	0.0863	0.83900
Transport of small molecules	76	6.04e-01	7.85e-01	0.2070	-0.10300	0.130000	0.009180	0.023400	0.12200	0.1610	0.145000	0.574	0.0863	0.83900
Transport of vitamins, nucleosides, and related molecules	5	6.04e-01	7.85e-01	0.3450	-0.20100	0.194000	-0.098400	0.078400	-0.15900	0.1610	0.145000	0.574	0.0863	0.83900
Metabolism	251	6.57e-01	7.85e-01	0.1720	0.04760	0.070500	-0.000650	-0.031000	-0.14600	0.1050	0.941000	0.799	0.7010	0.17500
Metabolism of amino acids and derivatives	78	6.57e-01	7.85e-01	0.3210	0.10700	0.164000	-0.045900	-0.126000	-0.21600	0.1050	0.941000	0.799	0.7010	0.17500
Metabolism of polyamines	9	6.57e-01	7.85e-01	0.3170	0.17400	0.026300	0.061900	0.027700	-0.25500	0.1050	0.941000	0.799	0.7010	0.17500
Regulation of ornithine decarboxylase (ODC)	6	6.57e-01	7.85e-01	0.3570	0.23000	0.026300	0.147000	0.027700	-0.22600	0.1050	0.941000	0.799	0.7010	0.17500
Major pathway of rRNA processing in the nucleolus and cytosol	79	6.82e-01	7.85e-01	0.4230	0.19400	0.165000	-0.034500	-0.148000	-0.30100	0.2110	0.879000	0.319	0.6400	0.19300
Metabolism of RNA	161	6.82e-01	7.85e-01	0.3980	0.21200	0.065900	0.052300	-0.097200	-0.31100	0.2110	0.879000	0.319	0.6400	0.19300
rRNA processing	82	6.82e-01	7.85e-01	0.4200	0.20000	0.161000	-0.030400	-0.137000	-0.30100	0.2110	0.879000	0.319	0.6400	0.19300
rRNA processing in the nucleus and cytosol	82	6.82e-01	7.85e-01	0.4200	0.20000	0.161000	-0.030400	-0.137000	-0.30100	0.2110	0.879000	0.319	0.6400	0.19300
Cellular response to heat stress	18	8.10e-01	8.49e-01	0.2550	0.18000	0.015300	0.081500	-0.061600	-0.14900	0.5990	0.908000	0.213	0.6910	0.19000
HSF1-dependent transactivation	8	8.10e-01	8.49e-01	0.2170	0.13000	-0.001860	0.045200	-0.098100	-0.13700	0.5990	0.908000	0.213	0.6910	0.19000
Cytokine Signaling in Immune system	97	8.49e-01	8.49e-01	0.1760	-0.09360	0.007000	0.024100	-0.067000	0.13000	0.5380	0.920000	0.263	0.8160	0.17000
Immune System	228	8.49e-01	8.49e-01	0.1750	-0.10500	0.005730	-0.002130	-0.015000	0.13900	0.5380	0.920000	0.263	0.8160	0.17000
Interferon Signaling	24	8.49e-01	8.49e-01	0.2860	-0.01620	0.074900	-0.126000	-0.109000	0.22000	0.5380	0.920000	0.263	0.8160	0.17000
Interferon gamma signaling	14	8.49e-01	8.49e-01	0.4630	-0.10000	0.086700	-0.147000	-0.007240	0.41900	0.5380	0.920000	0.263	0.8160	0.17000
ABC transporter disorders	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
ABC-family proteins mediated transport	10	NA	NA	0.1510	-0.00262	-0.019700	0.090800	-0.039500	-0.11300	NA	NA	NA	NA	NA
ADORA2B mediated anti-inflammatory cytokines production	5	NA	NA	0.6050	-0.25200	NaN	-0.220000	0.073100	0.49900	NA	NA	NA	NA	NA
APC-Cdc20 mediated degradation of Nek2A	8	NA	NA	0.6430	0.27000	-0.161000	0.088200	-0.207000	-0.51400	NA	NA	NA	NA	NA
APC/C-mediated degradation of cell cycle proteins	20	NA	NA	0.4410	0.15600	-0.137000	0.153000	-0.039500	-0.35500	NA	NA	NA	NA	NA
APC/C:Cdc20 mediated degradation of Cyclin B	8	NA	NA	0.5490	0.20500	-0.154000	0.112000	-0.207000	-0.42400	NA	NA	NA	NA	NA
APC/C:Cdc20 mediated degradation of Securin	12	NA	NA	0.4130	0.12400	-0.138000	0.142000	-0.039500	-0.33900	NA	NA	NA	NA	NA
APC/C:Cdc20 mediated degradation of mitotic proteins	17	NA	NA	0.4880	0.23700	-0.146000	0.143000	-0.039500	-0.37200	NA	NA	NA	NA	NA
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	14	NA	NA	0.4130	0.16300	-0.125000	0.155000	-0.039500	-0.32100	NA	NA	NA	NA	NA
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	15	NA	NA	0.4470	0.23700	-0.136000	0.105000	-0.039500	-0.33500	NA	NA	NA	NA	NA
AUF1 (hnRNP D0) binds and destabilizes mRNA	11	NA	NA	0.2790	0.13500	-0.056600	0.033400	-0.039500	-0.23100	NA	NA	NA	NA	NA
AURKA Activation by TPX2	13	NA	NA	0.3650	0.14700	-0.103000	0.166000	-0.110000	-0.24800	NA	NA	NA	NA	NA
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	6	NA	NA	0.1700	0.12700	0.060400	-0.071200	NaN	0.06440	NA	NA	NA	NA	NA
Aberrant regulation of mitotic cell cycle due to RB1 defects	8	NA	NA	0.2300	0.14200	-0.096500	0.010300	NaN	-0.15300	NA	NA	NA	NA	NA
Abortive elongation of HIV-1 transcript in the absence of Tat	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
Activated NOTCH1 Transmits Signal to the Nucleus	6	NA	NA	0.3610	-0.22800	NaN	-0.188000	-0.207000	0.00219	NA	NA	NA	NA	NA
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	18	NA	NA	0.4920	0.24300	-0.144000	0.154000	-0.039500	-0.37000	NA	NA	NA	NA	NA
Activation of ATR in response to replication stress	12	NA	NA	0.5580	0.38100	-0.092900	0.093100	NaN	-0.38600	NA	NA	NA	NA	NA
Activation of BH3-only proteins	5	NA	NA	0.2500	0.01180	NaN	0.245000	-0.008560	-0.04380	NA	NA	NA	NA	NA
Activation of HOX genes during differentiation	10	NA	NA	0.1060	0.01770	0.001980	0.046700	-0.072400	-0.05850	NA	NA	NA	NA	NA
Activation of Matrix Metalloproteinases	5	NA	NA	0.6690	-0.37500	0.162000	-0.063800	-0.194000	0.48900	NA	NA	NA	NA	NA
Activation of NF-kappaB in B cells	9	NA	NA	0.2850	-0.22800	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Activation of NMDA receptors and postsynaptic events	5	NA	NA	0.2500	-0.16100	0.019700	-0.094500	NaN	0.16400	NA	NA	NA	NA	NA
Activation of anterior HOX genes in hindbrain development during early embryogenesis	10	NA	NA	0.1060	0.01770	0.001980	0.046700	-0.072400	-0.05850	NA	NA	NA	NA	NA
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	27	NA	NA	0.4030	0.13300	0.159000	0.086600	-0.127000	-0.30900	NA	NA	NA	NA	NA
Activation of the pre-replicative complex	13	NA	NA	0.5370	0.36000	-0.097200	0.093100	NaN	-0.37600	NA	NA	NA	NA	NA
Adaptive Immune System	72	NA	NA	0.2940	-0.17800	-0.056900	-0.018200	0.037700	0.22300	NA	NA	NA	NA	NA
Adherens junctions interactions	5	NA	NA	0.4570	-0.24200	NaN	NaN	NaN	0.38800	NA	NA	NA	NA	NA
Aggrephagy	7	NA	NA	0.3610	0.04720	-0.063000	-0.188000	-0.207000	-0.21500	NA	NA	NA	NA	NA
Amino acid transport across the plasma membrane	6	NA	NA	0.3310	0.32700	NaN	NaN	NaN	0.05390	NA	NA	NA	NA	NA
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	25	NA	NA	0.4690	0.21400	-0.111000	0.184000	-0.025000	-0.35700	NA	NA	NA	NA	NA
Amplification of signal from the kinetochores	25	NA	NA	0.4690	0.21400	-0.111000	0.184000	-0.025000	-0.35700	NA	NA	NA	NA	NA
Amyloid fiber formation	15	NA	NA	0.4510	-0.31100	0.180000	-0.165000	-0.031100	0.21500	NA	NA	NA	NA	NA
Anchoring of the basal body to the plasma membrane	11	NA	NA	0.2860	0.14700	-0.083300	0.099300	-0.093300	-0.18700	NA	NA	NA	NA	NA
Anti-inflammatory response favouring Leishmania parasite infection	9	NA	NA	0.5120	-0.27800	NaN	-0.158000	0.073100	0.39300	NA	NA	NA	NA	NA
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	7	NA	NA	0.4950	-0.15400	NaN	-0.214000	0.015800	0.41900	NA	NA	NA	NA	NA
Antigen processing-Cross presentation	19	NA	NA	0.3230	-0.17200	-0.019700	-0.112000	0.026000	0.24800	NA	NA	NA	NA	NA
Antigen processing: Ubiquitination & Proteasome degradation	24	NA	NA	0.1700	-0.05720	-0.128000	0.087400	-0.039500	-0.01400	NA	NA	NA	NA	NA
Antiviral mechanism by IFN-stimulated genes	10	NA	NA	0.2730	0.09540	0.021100	-0.078200	-0.207000	-0.12500	NA	NA	NA	NA	NA
Apoptosis	26	NA	NA	0.2130	-0.01000	-0.057300	0.148000	-0.061700	-0.12800	NA	NA	NA	NA	NA
Apoptotic cleavage of cellular proteins	8	NA	NA	0.4090	-0.31800	-0.045800	0.051900	-0.120000	0.21600	NA	NA	NA	NA	NA
Apoptotic execution phase	11	NA	NA	0.2560	-0.13200	-0.084500	0.163000	-0.120000	-0.01390	NA	NA	NA	NA	NA
Aquaporin-mediated transport	5	NA	NA	0.4840	-0.26700	NaN	NaN	-0.025000	0.40300	NA	NA	NA	NA	NA
Arachidonic acid metabolism	6	NA	NA	0.3330	-0.05650	-0.035600	-0.056500	NaN	0.32100	NA	NA	NA	NA	NA
Asparagine N-linked glycosylation	21	NA	NA	0.2290	-0.18900	NaN	-0.011000	-0.020200	0.12700	NA	NA	NA	NA	NA
Assembly Of The HIV Virion	6	NA	NA	0.4850	-0.46000	NaN	-0.068500	-0.060600	0.12200	NA	NA	NA	NA	NA
Assembly of collagen fibrils and other multimeric structures	13	NA	NA	0.4330	-0.22100	0.093200	-0.114000	-0.081000	0.33300	NA	NA	NA	NA	NA
Assembly of the pre-replicative complex	16	NA	NA	0.4590	0.34400	-0.092400	0.061100	-0.039500	-0.28100	NA	NA	NA	NA	NA
Association of TriC/CCT with target proteins during biosynthesis	10	NA	NA	0.3730	0.25600	0.036900	0.089500	-0.143000	-0.20900	NA	NA	NA	NA	NA
Asymmetric localization of PCP proteins	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Attenuation phase	6	NA	NA	0.4820	0.20200	-0.024500	0.125000	-0.121000	-0.40100	NA	NA	NA	NA	NA
Autodegradation of Cdh1 by Cdh1:APC/C	10	NA	NA	0.3510	0.08530	-0.123000	0.088200	-0.039500	-0.30200	NA	NA	NA	NA	NA
Autodegradation of the E3 ubiquitin ligase COP1	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Autophagy	19	NA	NA	0.2160	-0.05700	0.041000	-0.003300	-0.109000	-0.17200	NA	NA	NA	NA	NA
Axon guidance	120	NA	NA	0.2140	-0.06270	0.160000	-0.095000	-0.064200	0.05700	NA	NA	NA	NA	NA
BBSome-mediated cargo-targeting to cilium	7	NA	NA	0.4090	0.30700	0.018400	0.130000	-0.173000	-0.16100	NA	NA	NA	NA	NA
Base Excision Repair	10	NA	NA	0.4090	0.28400	-0.097500	0.018900	NaN	-0.27600	NA	NA	NA	NA	NA
Basigin interactions	9	NA	NA	0.4070	-0.15100	0.109000	-0.036700	0.169000	0.31700	NA	NA	NA	NA	NA
Beta-catenin independent WNT signaling	21	NA	NA	0.1210	0.08120	0.063000	-0.058100	-0.025500	-0.00285	NA	NA	NA	NA	NA
Binding and Uptake of Ligands by Scavenger Receptors	10	NA	NA	0.3360	-0.18300	0.055900	-0.047200	NaN	0.27200	NA	NA	NA	NA	NA
Biological oxidations	14	NA	NA	0.2420	0.03690	-0.165000	0.116000	-0.102000	-0.07950	NA	NA	NA	NA	NA
Budding and maturation of HIV virion	6	NA	NA	0.4650	-0.44700	NaN	-0.068500	-0.060600	0.08980	NA	NA	NA	NA	NA
C-type lectin receptors (CLRs)	15	NA	NA	0.2800	-0.27000	0.063900	-0.002640	0.037400	-0.00610	NA	NA	NA	NA	NA
CDK-mediated phosphorylation and removal of Cdc6	11	NA	NA	0.3970	0.17900	-0.132000	0.072800	-0.039500	-0.31800	NA	NA	NA	NA	NA
CDT1 association with the CDC6:ORC:origin complex	11	NA	NA	0.3690	0.28300	-0.097400	0.043400	-0.039500	-0.20800	NA	NA	NA	NA	NA
CHL1 interactions	5	NA	NA	0.4960	-0.15800	0.164000	-0.077800	-0.048400	0.43100	NA	NA	NA	NA	NA
CLEC7A (Dectin-1) signaling	13	NA	NA	0.2860	-0.27000	0.063900	-0.002640	-0.039500	-0.05740	NA	NA	NA	NA	NA
COPI-dependent Golgi-to-ER retrograde traffic	13	NA	NA	0.2060	0.04380	-0.072300	0.095300	0.037100	-0.15700	NA	NA	NA	NA	NA
COPI-mediated anterograde transport	9	NA	NA	0.1960	-0.14400	NaN	-0.049900	0.041400	0.11700	NA	NA	NA	NA	NA
Ca2+ pathway	6	NA	NA	0.2440	0.00657	0.104000	-0.094500	-0.084900	0.18000	NA	NA	NA	NA	NA
Cap-dependent Translation Initiation	58	NA	NA	0.3920	0.13800	0.176000	-0.065400	-0.157000	-0.27300	NA	NA	NA	NA	NA
Carboxyterminal post-translational modifications of tubulin	8	NA	NA	0.5010	0.29700	-0.045100	0.182000	0.018500	-0.35700	NA	NA	NA	NA	NA
Cardiac conduction	10	NA	NA	0.4380	-0.22400	0.152000	-0.063100	0.090700	0.32600	NA	NA	NA	NA	NA
Cargo recognition for clathrin-mediated endocytosis	13	NA	NA	0.3090	-0.24800	NaN	-0.092200	0.005550	0.15800	NA	NA	NA	NA	NA
Cargo trafficking to the periciliary membrane	8	NA	NA	0.3900	0.30700	0.018400	0.130000	-0.122000	-0.16100	NA	NA	NA	NA	NA
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	15	NA	NA	0.4470	0.23700	-0.136000	0.105000	-0.039500	-0.33500	NA	NA	NA	NA	NA
Cell Cycle	137	NA	NA	0.4520	0.20500	-0.123000	0.159000	-0.040400	-0.34700	NA	NA	NA	NA	NA
Cell Cycle Checkpoints	59	NA	NA	0.4780	0.22800	-0.123000	0.166000	0.001060	-0.36600	NA	NA	NA	NA	NA
Cell Cycle, Mitotic	115	NA	NA	0.4660	0.22500	-0.123000	0.161000	-0.068200	-0.34800	NA	NA	NA	NA	NA
Cell death signalling via NRAGE, NRIF and NADE	11	NA	NA	0.3240	-0.25700	-0.110000	-0.109000	-0.059300	0.10800	NA	NA	NA	NA	NA
Cell junction organization	10	NA	NA	0.5100	-0.27100	NaN	-0.013200	-0.211000	0.37700	NA	NA	NA	NA	NA
Cell surface interactions at the vascular wall	22	NA	NA	0.4010	-0.15700	0.109000	-0.042600	-0.016900	0.34900	NA	NA	NA	NA	NA
Cell-Cell communication	13	NA	NA	0.4970	-0.24200	NaN	-0.002640	-0.211000	0.38000	NA	NA	NA	NA	NA
Cell-cell junction organization	5	NA	NA	0.4570	-0.24200	NaN	NaN	NaN	0.38800	NA	NA	NA	NA	NA
Cellular response to hypoxia	10	NA	NA	0.0657	-0.00262	-0.019700	0.043400	-0.039500	0.02190	NA	NA	NA	NA	NA
Centrosome maturation	12	NA	NA	0.3190	0.15900	-0.080500	0.111000	-0.130000	-0.20100	NA	NA	NA	NA	NA
Chaperone Mediated Autophagy	8	NA	NA	0.4230	0.17400	0.069800	0.027600	-0.174000	-0.33600	NA	NA	NA	NA	NA
Chaperonin-mediated protein folding	22	NA	NA	0.2800	0.19100	-0.013600	0.127000	-0.024200	-0.15900	NA	NA	NA	NA	NA
Cholesterol biosynthesis	5	NA	NA	0.3450	0.29100	-0.051200	0.124000	-0.097400	-0.08490	NA	NA	NA	NA	NA
Chondroitin sulfate/dermatan sulfate metabolism	5	NA	NA	0.2880	-0.25800	NaN	-0.026800	0.051100	0.11300	NA	NA	NA	NA	NA
Chromatin modifying enzymes	15	NA	NA	0.3030	0.11100	-0.073500	0.138000	-0.196000	-0.12800	NA	NA	NA	NA	NA
Chromatin organization	15	NA	NA	0.3030	0.11100	-0.073500	0.138000	-0.196000	-0.12800	NA	NA	NA	NA	NA
Chromosome Maintenance	26	NA	NA	0.4100	0.20300	-0.084300	0.117000	0.026900	-0.32400	NA	NA	NA	NA	NA
Cilium Assembly	21	NA	NA	0.2580	0.12200	-0.066500	0.115000	-0.126000	-0.13400	NA	NA	NA	NA	NA
Circadian Clock	10	NA	NA	0.2520	-0.07990	NaN	0.038000	-0.211000	0.10600	NA	NA	NA	NA	NA
Class B/2 (Secretin family receptors)	6	NA	NA	0.5530	-0.25200	NaN	-0.220000	0.073100	0.43400	NA	NA	NA	NA	NA
Class I MHC mediated antigen processing & presentation	35	NA	NA	0.2270	-0.11200	-0.128000	-0.013700	0.026000	0.14700	NA	NA	NA	NA	NA
Clathrin-mediated endocytosis	16	NA	NA	0.2530	-0.21500	NaN	-0.092200	0.005550	0.09780	NA	NA	NA	NA	NA
Collagen biosynthesis and modifying enzymes	12	NA	NA	0.3040	-0.19800	0.128000	-0.033400	-0.007040	0.18900	NA	NA	NA	NA	NA
Collagen chain trimerization	9	NA	NA	0.3880	-0.20300	0.144000	-0.087900	-0.081000	0.27200	NA	NA	NA	NA	NA
Collagen degradation	9	NA	NA	0.4940	-0.28200	0.093200	-0.063700	-0.194000	0.33800	NA	NA	NA	NA	NA
Collagen formation	18	NA	NA	0.3820	-0.21900	0.117000	-0.073000	-0.007040	0.28100	NA	NA	NA	NA	NA
Complex I biogenesis	11	NA	NA	0.2780	-0.06170	0.014400	-0.061700	0.050800	-0.25900	NA	NA	NA	NA	NA
Condensation of Prometaphase Chromosomes	7	NA	NA	0.4020	0.20100	-0.148000	0.178000	NaN	-0.26000	NA	NA	NA	NA	NA
Condensation of Prophase Chromosomes	7	NA	NA	0.4420	0.25300	-0.112000	0.181000	-0.116000	-0.26900	NA	NA	NA	NA	NA
Constitutive Signaling by Aberrant PI3K in Cancer	8	NA	NA	0.3110	-0.27300	NaN	0.018400	NaN	0.14800	NA	NA	NA	NA	NA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	5	NA	NA	0.4610	0.32100	-0.063000	-0.188000	-0.207000	-0.16600	NA	NA	NA	NA	NA
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	10	NA	NA	0.2250	-0.07270	0.085400	0.059300	-0.185000	-0.01530	NA	NA	NA	NA	NA
Constitutive Signaling by NOTCH1 PEST Domain Mutants	10	NA	NA	0.2250	-0.07270	0.085400	0.059300	-0.185000	-0.01530	NA	NA	NA	NA	NA
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	10	NA	NA	0.2040	0.00853	0.018400	0.145000	-0.087600	-0.11200	NA	NA	NA	NA	NA
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	18	NA	NA	0.3260	0.19500	-0.025100	0.170000	-0.022200	-0.19600	NA	NA	NA	NA	NA
Costimulation by the CD28 family	6	NA	NA	0.1740	NaN	NaN	0.018400	NaN	0.17300	NA	NA	NA	NA	NA
Cristae formation	11	NA	NA	0.5350	-0.47500	NaN	-0.021000	0.111000	-0.21900	NA	NA	NA	NA	NA
Cross-presentation of soluble exogenous antigens (endosomes)	6	NA	NA	0.3150	-0.00262	-0.019700	0.274000	0.129000	0.08470	NA	NA	NA	NA	NA
Cyclin A/B1/B2 associated events during G2/M transition	7	NA	NA	0.4760	0.29700	-0.146000	0.193000	NaN	-0.28200	NA	NA	NA	NA	NA
Cyclin A:Cdk2-associated events at S phase entry	15	NA	NA	0.3320	0.16600	-0.072900	0.058300	-0.072600	-0.26200	NA	NA	NA	NA	NA
Cyclin D associated events in G1	14	NA	NA	0.2270	-0.05610	-0.003080	-0.033600	-0.207000	-0.06410	NA	NA	NA	NA	NA
Cyclin E associated events during G1/S transition	15	NA	NA	0.3320	0.16600	-0.072900	0.058300	-0.072600	-0.26200	NA	NA	NA	NA	NA
Cytosolic sensors of pathogen-associated DNA	14	NA	NA	0.2640	0.12400	0.048900	-0.013500	-0.112000	-0.19800	NA	NA	NA	NA	NA
DAP12 interactions	8	NA	NA	0.4010	-0.12500	NaN	-0.264000	0.044600	0.27100	NA	NA	NA	NA	NA
DAP12 signaling	6	NA	NA	0.3840	-0.09960	NaN	-0.282000	0.044600	0.23700	NA	NA	NA	NA	NA
DDX58/IFIH1-mediated induction of interferon-alpha/beta	6	NA	NA	0.6100	-0.26500	-0.003950	0.028100	0.001980	-0.54900	NA	NA	NA	NA	NA
DNA Damage Bypass	10	NA	NA	0.4680	0.24800	-0.092600	-0.005920	-0.207000	-0.32500	NA	NA	NA	NA	NA
DNA Damage Recognition in GG-NER	9	NA	NA	0.4160	0.23700	-0.148000	0.041700	-0.064900	-0.29800	NA	NA	NA	NA	NA
DNA Double Strand Break Response	9	NA	NA	0.3530	0.14200	0.036900	-0.074300	-0.207000	-0.23300	NA	NA	NA	NA	NA
DNA Double-Strand Break Repair	22	NA	NA	0.4140	0.23700	-0.056300	0.058500	-0.207000	-0.25600	NA	NA	NA	NA	NA
DNA Repair	39	NA	NA	0.3470	0.22100	-0.070400	0.039600	-0.006440	-0.25500	NA	NA	NA	NA	NA
DNA Replication	30	NA	NA	0.4760	0.28500	-0.108000	0.081200	-0.039500	-0.35400	NA	NA	NA	NA	NA
DNA Replication Pre-Initiation	21	NA	NA	0.4640	0.32700	-0.089800	0.073600	-0.039500	-0.30500	NA	NA	NA	NA	NA
DNA strand elongation	12	NA	NA	0.5390	0.36500	-0.092300	0.136000	NaN	-0.36200	NA	NA	NA	NA	NA
Deactivation of the beta-catenin transactivating complex	8	NA	NA	0.3780	-0.26900	0.122000	-0.188000	-0.060300	0.12900	NA	NA	NA	NA	NA
Deadenylation-dependent mRNA decay	11	NA	NA	0.4070	0.19600	-0.042800	0.145000	NaN	-0.32300	NA	NA	NA	NA	NA
Death Receptor Signalling	14	NA	NA	0.3310	-0.27200	-0.110000	-0.033100	-0.059300	0.13800	NA	NA	NA	NA	NA
Dectin-1 mediated noncanonical NF-kB signaling	9	NA	NA	0.2850	-0.22800	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Defective CFTR causes cystic fibrosis	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	6	NA	NA	0.1700	0.12700	0.060400	-0.071200	NaN	0.06440	NA	NA	NA	NA	NA
Degradation of AXIN	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Degradation of DVL	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Degradation of GLI1 by the proteasome	9	NA	NA	0.2850	-0.22800	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Degradation of GLI2 by the proteasome	10	NA	NA	0.2390	-0.22800	-0.019700	0.043400	-0.039500	-0.03550	NA	NA	NA	NA	NA
Degradation of beta-catenin by the destruction complex	14	NA	NA	0.1130	-0.00263	0.063000	0.043400	-0.072600	-0.03970	NA	NA	NA	NA	NA
Degradation of the extracellular matrix	18	NA	NA	0.5500	-0.32500	0.143000	-0.079200	-0.000658	0.41300	NA	NA	NA	NA	NA
Depolymerisation of the Nuclear Lamina	5	NA	NA	0.5100	0.06440	-0.101000	0.227000	-0.080100	-0.43400	NA	NA	NA	NA	NA
Deposition of new CENPA-containing nucleosomes at the centromere	13	NA	NA	0.4790	0.12300	-0.109000	0.203000	-0.049900	-0.39800	NA	NA	NA	NA	NA
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	6	NA	NA	0.4040	-0.12700	0.000881	0.218000	-0.080100	-0.30600	NA	NA	NA	NA	NA
Detoxification of Reactive Oxygen Species	10	NA	NA	0.2720	0.03940	0.060600	-0.043500	0.021600	-0.25800	NA	NA	NA	NA	NA
Deubiquitination	28	NA	NA	0.2580	0.16000	-0.057800	0.070100	-0.040400	-0.17600	NA	NA	NA	NA	NA
Disease	207	NA	NA	0.1150	0.00171	0.071900	0.023000	-0.034300	-0.07950	NA	NA	NA	NA	NA
Diseases associated with glycosaminoglycan metabolism	5	NA	NA	0.3490	-0.31800	NaN	-0.021500	0.077800	-0.11900	NA	NA	NA	NA	NA
Diseases of carbohydrate metabolism	6	NA	NA	0.5050	0.22900	NaN	-0.188000	-0.207000	-0.35200	NA	NA	NA	NA	NA
Diseases of glycosylation	10	NA	NA	0.2950	-0.27800	NaN	-0.021500	0.096700	0.00473	NA	NA	NA	NA	NA
Diseases of metabolism	19	NA	NA	0.1830	-0.11200	NaN	-0.028100	0.058300	-0.12900	NA	NA	NA	NA	NA
Diseases of mitotic cell cycle	8	NA	NA	0.2300	0.14200	-0.096500	0.010300	NaN	-0.15300	NA	NA	NA	NA	NA
Diseases of programmed cell death	7	NA	NA	0.4650	-0.00580	0.000881	0.218000	-0.084900	-0.40200	NA	NA	NA	NA	NA
Diseases of signal transduction by growth factor receptors and second messengers	48	NA	NA	0.1490	-0.07450	0.038800	0.085000	-0.084800	0.02630	NA	NA	NA	NA	NA
Disorders of transmembrane transporters	14	NA	NA	0.1190	0.07070	-0.019700	0.058000	0.026000	-0.06930	NA	NA	NA	NA	NA
Downregulation of ERBB2 signaling	5	NA	NA	0.6460	0.32100	-0.063000	-0.188000	-0.207000	-0.48100	NA	NA	NA	NA	NA
Downregulation of SMAD2/3:SMAD4 transcriptional activity	5	NA	NA	0.5480	0.17500	-0.148000	0.046100	-0.207000	-0.45000	NA	NA	NA	NA	NA
Downregulation of TGF-beta receptor signaling	10	NA	NA	0.2410	-0.00876	0.015800	-0.026800	-0.139000	-0.19400	NA	NA	NA	NA	NA
Downstream TCR signaling	12	NA	NA	0.2480	-0.22800	-0.019700	0.043400	-0.039500	-0.07260	NA	NA	NA	NA	NA
Downstream signaling events of B Cell Receptor (BCR)	13	NA	NA	0.2830	-0.27000	0.063900	0.042900	-0.008370	-0.02890	NA	NA	NA	NA	NA
Dual Incision in GG-NER	9	NA	NA	0.4890	0.26900	-0.097500	0.012300	-0.207000	-0.33800	NA	NA	NA	NA	NA
Dual incision in TC-NER	13	NA	NA	0.2700	0.14700	-0.040400	-0.065500	0.003960	-0.21300	NA	NA	NA	NA	NA
E2F mediated regulation of DNA replication	6	NA	NA	0.5460	0.37700	-0.153000	0.266000	NaN	-0.24900	NA	NA	NA	NA	NA
E3 ubiquitin ligases ubiquitinate target proteins	8	NA	NA	0.2430	-0.01930	-0.105000	-0.182000	-0.115000	-0.03450	NA	NA	NA	NA	NA
ECM proteoglycans	10	NA	NA	0.3310	-0.21900	0.143000	-0.014600	0.007620	0.20100	NA	NA	NA	NA	NA
EGR2 and SOX10-mediated initiation of Schwann cell myelination	6	NA	NA	0.3450	-0.04330	NaN	0.076900	0.045300	-0.33000	NA	NA	NA	NA	NA
EML4 and NUDC in mitotic spindle formation	25	NA	NA	0.4690	0.21400	-0.111000	0.184000	-0.025000	-0.35700	NA	NA	NA	NA	NA
EPH-Ephrin signaling	17	NA	NA	0.5050	-0.33300	NaN	-0.168000	-0.036200	0.33800	NA	NA	NA	NA	NA
EPH-ephrin mediated repulsion of cells	9	NA	NA	0.4750	-0.27900	NaN	-0.135000	-0.036200	0.35800	NA	NA	NA	NA	NA
EPHB-mediated forward signaling	6	NA	NA	0.3560	-0.35000	NaN	NaN	NaN	0.06360	NA	NA	NA	NA	NA
ER to Golgi Anterograde Transport	12	NA	NA	0.1730	-0.13500	NaN	-0.049900	-0.005630	0.09610	NA	NA	NA	NA	NA
ER-Phagosome pathway	16	NA	NA	0.2800	-0.17200	-0.019700	-0.112000	0.026000	0.18800	NA	NA	NA	NA	NA
ESR-mediated signaling	34	NA	NA	0.0714	0.00933	0.012200	0.004490	-0.067300	-0.01740	NA	NA	NA	NA	NA
Early Phase of HIV Life Cycle	6	NA	NA	0.5940	0.27500	0.014500	0.166000	-0.129000	-0.48300	NA	NA	NA	NA	NA
Elastic fibre formation	7	NA	NA	0.5460	-0.15300	NaN	-0.106000	-0.159000	0.48800	NA	NA	NA	NA	NA
Endosomal Sorting Complex Required For Transport (ESCRT)	5	NA	NA	0.4980	-0.44700	NaN	-0.192000	-0.060600	0.08980	NA	NA	NA	NA	NA
Endosomal/Vacuolar pathway	6	NA	NA	0.4800	-0.15400	NaN	-0.214000	0.044600	0.39800	NA	NA	NA	NA	NA
Estrogen-dependent gene expression	24	NA	NA	0.2000	0.09720	0.002160	0.052800	-0.043400	-0.16100	NA	NA	NA	NA	NA
Eukaryotic Translation Elongation	52	NA	NA	0.4390	0.18700	0.186000	-0.131000	-0.148000	-0.28900	NA	NA	NA	NA	NA
Eukaryotic Translation Initiation	58	NA	NA	0.3920	0.13800	0.176000	-0.065400	-0.157000	-0.27300	NA	NA	NA	NA	NA
Eukaryotic Translation Termination	50	NA	NA	0.4210	0.16800	0.184000	-0.131000	-0.156000	-0.27200	NA	NA	NA	NA	NA
Extension of Telomeres	10	NA	NA	0.4570	0.31800	-0.066200	0.071600	0.068300	-0.30600	NA	NA	NA	NA	NA
Extra-nuclear estrogen signaling	13	NA	NA	0.2920	-0.14600	0.023100	-0.030100	-0.113000	0.22300	NA	NA	NA	NA	NA
Extracellular matrix organization	47	NA	NA	0.4620	-0.23100	0.144000	-0.076300	-0.039400	0.36300	NA	NA	NA	NA	NA
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	10	NA	NA	0.2930	-0.22800	-0.034900	0.076000	-0.039500	-0.15900	NA	NA	NA	NA	NA
FCERI mediated MAPK activation	5	NA	NA	0.1290	-0.06680	NaN	NaN	NaN	0.11100	NA	NA	NA	NA	NA
FCERI mediated NF-kB activation	10	NA	NA	0.3100	-0.22800	-0.019700	0.043400	-0.039500	-0.20100	NA	NA	NA	NA	NA
FCGR3A-mediated phagocytosis	8	NA	NA	0.4290	-0.35000	NaN	-0.235000	0.052500	0.06360	NA	NA	NA	NA	NA
FGFR2 alternative splicing	9	NA	NA	0.2630	0.12000	0.077500	-0.184000	0.061700	-0.10500	NA	NA	NA	NA	NA
FGFR2 mutant receptor activation	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
FLT3 Signaling	31	NA	NA	0.2290	-0.16200	-0.019700	0.046000	-0.058300	0.14300	NA	NA	NA	NA	NA
FOXO-mediated transcription	10	NA	NA	0.3370	-0.27500	0.146000	0.043600	0.024400	0.11900	NA	NA	NA	NA	NA
Factors involved in megakaryocyte development and platelet production	14	NA	NA	0.2380	0.15600	-0.068600	0.093800	0.025500	-0.13500	NA	NA	NA	NA	NA
Fanconi Anemia Pathway	8	NA	NA	0.5390	0.26400	-0.115000	0.032500	-0.207000	-0.40400	NA	NA	NA	NA	NA
Fatty acid metabolism	14	NA	NA	0.1480	-0.04470	-0.007490	-0.056500	0.016300	0.12800	NA	NA	NA	NA	NA
Fc epsilon receptor (FCERI) signaling	18	NA	NA	0.2350	-0.22000	0.063900	-0.002640	-0.039500	0.03320	NA	NA	NA	NA	NA
Fcgamma receptor (FCGR) dependent phagocytosis	12	NA	NA	0.1660	-0.14200	-0.063000	-0.045700	-0.030800	0.01890	NA	NA	NA	NA	NA
Folding of actin by CCT/TriC	8	NA	NA	0.2980	0.09310	0.018400	0.145000	-0.143000	-0.19600	NA	NA	NA	NA	NA
Formation of ATP by chemiosmotic coupling	9	NA	NA	0.5520	-0.47500	NaN	-0.177000	0.111000	-0.19000	NA	NA	NA	NA	NA
Formation of HIV elongation complex in the absence of HIV Tat	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Formation of HIV-1 elongation complex containing HIV-1 Tat	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Formation of Incision Complex in GG-NER	8	NA	NA	0.4310	0.19800	-0.119000	0.012300	-0.207000	-0.29900	NA	NA	NA	NA	NA
Formation of RNA Pol II elongation complex	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Formation of TC-NER Pre-Incision Complex	10	NA	NA	0.1720	0.07050	0.077500	-0.036000	-0.021800	-0.13000	NA	NA	NA	NA	NA
Formation of a pool of free 40S subunits	53	NA	NA	0.4130	0.15400	0.176000	-0.097300	-0.157000	-0.28600	NA	NA	NA	NA	NA
Formation of the Early Elongation Complex	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
Formation of the HIV-1 Early Elongation Complex	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
Formation of the beta-catenin:TCF transactivating complex	7	NA	NA	0.3650	0.31500	0.104000	NaN	-0.138000	-0.06160	NA	NA	NA	NA	NA
Formation of the ternary complex, and subsequently, the 43S complex	24	NA	NA	0.4000	0.15200	0.159000	0.086600	-0.127000	-0.29600	NA	NA	NA	NA	NA
Formation of tubulin folding intermediates by CCT/TriC	15	NA	NA	0.4040	0.27700	-0.032500	0.153000	-0.022200	-0.24800	NA	NA	NA	NA	NA
G alpha (12/13) signalling events	6	NA	NA	0.5010	-0.13800	-0.110000	-0.078200	0.014100	0.46200	NA	NA	NA	NA	NA
G alpha (q) signalling events	6	NA	NA	0.3610	-0.06570	0.119000	-0.085300	0.027200	0.32200	NA	NA	NA	NA	NA
G alpha (s) signalling events	5	NA	NA	0.6050	-0.25200	NaN	-0.220000	0.073100	0.49900	NA	NA	NA	NA	NA
G0 and Early G1	7	NA	NA	0.5350	0.34500	-0.091900	0.072300	-0.138000	-0.36600	NA	NA	NA	NA	NA
G1 Phase	14	NA	NA	0.2270	-0.05610	-0.003080	-0.033600	-0.207000	-0.06410	NA	NA	NA	NA	NA
G1/S DNA Damage Checkpoints	11	NA	NA	0.2930	0.13500	-0.086900	0.055500	-0.039500	-0.23500	NA	NA	NA	NA	NA
G1/S Transition	37	NA	NA	0.4620	0.29300	-0.107000	0.099800	-0.072600	-0.31900	NA	NA	NA	NA	NA
G1/S-Specific Transcription	9	NA	NA	0.5190	0.33200	-0.116000	0.144000	NaN	-0.35300	NA	NA	NA	NA	NA
G2/M Checkpoints	29	NA	NA	0.4450	0.23400	-0.106000	0.150000	0.018500	-0.33000	NA	NA	NA	NA	NA
G2/M DNA damage checkpoint	9	NA	NA	0.3970	0.00685	-0.102000	0.230000	0.134000	-0.27700	NA	NA	NA	NA	NA
G2/M Transition	34	NA	NA	0.3690	0.11600	-0.123000	0.169000	-0.089100	-0.26700	NA	NA	NA	NA	NA
GLI3 is processed to GLI3R by the proteasome	10	NA	NA	0.2390	-0.22800	-0.019700	0.043400	-0.039500	-0.03550	NA	NA	NA	NA	NA
GTP hydrolysis and joining of the 60S ribosomal subunit	56	NA	NA	0.3810	0.13800	0.176000	-0.065400	-0.157000	-0.25700	NA	NA	NA	NA	NA
Gap-filling DNA repair synthesis and ligation in GG-NER	8	NA	NA	0.4430	0.22300	-0.079700	-0.005920	-0.207000	-0.31200	NA	NA	NA	NA	NA
Gap-filling DNA repair synthesis and ligation in TC-NER	13	NA	NA	0.2700	0.14700	-0.040400	-0.065500	0.003960	-0.21300	NA	NA	NA	NA	NA
Gene Silencing by RNA	10	NA	NA	0.3430	0.17400	0.007250	0.112000	-0.060300	-0.26700	NA	NA	NA	NA	NA
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	14	NA	NA	0.4170	0.07700	-0.092800	0.200000	-0.098400	-0.33200	NA	NA	NA	NA	NA
Global Genome Nucleotide Excision Repair (GG-NER)	16	NA	NA	0.3720	0.22000	-0.097500	0.075600	-0.064900	-0.26500	NA	NA	NA	NA	NA
Gluconeogenesis	6	NA	NA	0.4380	0.26000	NaN	0.146000	NaN	-0.32100	NA	NA	NA	NA	NA
Glucose metabolism	12	NA	NA	0.3720	0.28900	0.021000	0.116000	NaN	-0.20100	NA	NA	NA	NA	NA
Glutamate binding, activation of AMPA receptors and synaptic plasticity	6	NA	NA	0.5750	0.14200	NaN	0.123000	0.151000	0.52200	NA	NA	NA	NA	NA
Glutathione conjugation	5	NA	NA	0.3340	0.18900	NaN	0.085200	-0.193000	-0.17800	NA	NA	NA	NA	NA
Glycerophospholipid biosynthesis	7	NA	NA	0.1290	-0.04540	NaN	0.053000	-0.053700	0.09390	NA	NA	NA	NA	NA
Glycogen metabolism	5	NA	NA	0.4610	-0.35300	NaN	-0.141000	-0.207000	0.15900	NA	NA	NA	NA	NA
Glycolysis	10	NA	NA	0.3530	0.29400	0.021000	0.116000	NaN	-0.15600	NA	NA	NA	NA	NA
Glycosaminoglycan metabolism	8	NA	NA	0.3290	-0.27600	-0.155000	0.033100	0.077800	0.02300	NA	NA	NA	NA	NA
Golgi Cisternae Pericentriolar Stack Reorganization	5	NA	NA	0.4840	0.13100	-0.143000	0.253000	NaN	-0.36500	NA	NA	NA	NA	NA
Golgi-to-ER retrograde transport	15	NA	NA	0.1670	-0.06270	-0.072300	0.095300	0.037100	-0.09170	NA	NA	NA	NA	NA
HCMV Early Events	9	NA	NA	0.1870	0.02510	-0.109000	0.074600	-0.130000	-0.00702	NA	NA	NA	NA	NA
HCMV Infection	11	NA	NA	0.1760	-0.09380	-0.109000	0.020400	-0.057700	0.08220	NA	NA	NA	NA	NA
HDR through Homologous Recombination (HRR)	9	NA	NA	0.4220	0.22300	-0.073300	-0.005920	-0.207000	-0.28200	NA	NA	NA	NA	NA
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	15	NA	NA	0.4210	0.23800	-0.090300	-0.000439	-0.207000	-0.26400	NA	NA	NA	NA	NA
HIV Infection	44	NA	NA	0.1210	0.02790	-0.012900	0.058000	0.025500	-0.09810	NA	NA	NA	NA	NA
HIV Life Cycle	27	NA	NA	0.2230	0.12100	-0.017600	0.069700	-0.045800	-0.16600	NA	NA	NA	NA	NA
HIV Transcription Elongation	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
HIV Transcription Initiation	6	NA	NA	0.2330	0.07050	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
HIV elongation arrest and recovery	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
HSF1 activation	7	NA	NA	0.5540	0.26000	0.002890	0.138000	-0.157000	-0.44200	NA	NA	NA	NA	NA
HSP90 chaperone cycle for steroid hormone receptors (SHR)	9	NA	NA	0.2830	0.06040	-0.053700	0.160000	-0.121000	-0.18200	NA	NA	NA	NA	NA
Hedgehog 'off' state	11	NA	NA	0.3170	-0.30500	-0.019700	0.043400	-0.039500	0.05970	NA	NA	NA	NA	NA
Hedgehog 'on' state	9	NA	NA	0.0714	-0.00262	-0.019700	0.043400	-0.039500	-0.03550	NA	NA	NA	NA	NA
Hedgehog ligand biogenesis	9	NA	NA	0.0743	-0.00262	-0.019700	0.043400	-0.039500	-0.04100	NA	NA	NA	NA	NA
Hemostasis	81	NA	NA	0.3560	-0.20400	0.054200	-0.072000	0.020800	0.27600	NA	NA	NA	NA	NA
Hh mutants abrogate ligand secretion	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Homology Directed Repair	17	NA	NA	0.4560	0.27300	-0.099300	0.011900	-0.207000	-0.28300	NA	NA	NA	NA	NA
Host Interactions of HIV factors	30	NA	NA	0.1630	0.04190	-0.052400	0.086700	0.012600	-0.12000	NA	NA	NA	NA	NA
ISG15 antiviral mechanism	10	NA	NA	0.2730	0.09540	0.021100	-0.078200	-0.207000	-0.12500	NA	NA	NA	NA	NA
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	11	NA	NA	0.5830	-0.21600	NaN	-0.191000	0.044600	0.50500	NA	NA	NA	NA	NA
Inactivation of APC/C via direct inhibition of the APC/C complex	5	NA	NA	0.6380	0.27000	-0.161000	0.157000	NaN	-0.53300	NA	NA	NA	NA	NA
Infection with Mycobacterium tuberculosis	8	NA	NA	0.2540	0.08920	0.033600	-0.032400	-0.081600	-0.21900	NA	NA	NA	NA	NA
Infectious disease	146	NA	NA	0.1380	0.02460	0.087400	0.004260	-0.049600	-0.09070	NA	NA	NA	NA	NA
Influenza Infection	63	NA	NA	0.3930	0.17400	0.146000	-0.069000	-0.135000	-0.28300	NA	NA	NA	NA	NA
Influenza Viral RNA Transcription and Replication	59	NA	NA	0.4010	0.19000	0.156000	-0.101000	-0.131000	-0.27000	NA	NA	NA	NA	NA
Inhibition of DNA recombination at telomere	5	NA	NA	0.2630	0.07050	0.077500	-0.184000	0.061700	-0.14400	NA	NA	NA	NA	NA
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	5	NA	NA	0.6380	0.27000	-0.161000	0.157000	NaN	-0.53300	NA	NA	NA	NA	NA
Initiation of Nuclear Envelope (NE) Reformation	8	NA	NA	0.4630	0.11900	-0.089300	0.233000	-0.080100	-0.36200	NA	NA	NA	NA	NA
Innate Immune System	130	NA	NA	0.1730	-0.11300	0.043800	-0.042800	0.020100	0.11500	NA	NA	NA	NA	NA
Integration of energy metabolism	10	NA	NA	0.2220	-0.08260	NaN	-0.015700	-0.122000	0.16500	NA	NA	NA	NA	NA
Integration of provirus	5	NA	NA	0.5800	0.24100	0.014500	0.166000	-0.129000	-0.48300	NA	NA	NA	NA	NA
Integrin cell surface interactions	9	NA	NA	0.5420	-0.20900	0.164000	-0.046000	-0.054600	0.46700	NA	NA	NA	NA	NA
Interactions of Rev with host cellular proteins	8	NA	NA	0.6360	0.20800	-0.077700	0.198000	-0.108000	-0.55100	NA	NA	NA	NA	NA
Interactions of Vpr with host cellular proteins	6	NA	NA	0.5570	0.22300	-0.032800	0.086600	0.013200	-0.50200	NA	NA	NA	NA	NA
Interconversion of nucleotide di- and triphosphates	12	NA	NA	0.4620	0.22100	-0.085000	-0.053500	-0.052500	-0.39000	NA	NA	NA	NA	NA
Interferon alpha/beta signaling	8	NA	NA	0.5490	-0.14000	0.168000	-0.119000	-0.209000	0.44200	NA	NA	NA	NA	NA
Interleukin-1 family signaling	14	NA	NA	0.3320	-0.24400	-0.009250	0.067000	0.044500	-0.21000	NA	NA	NA	NA	NA
Interleukin-1 signaling	13	NA	NA	0.3350	-0.24400	-0.009250	0.078900	0.044500	-0.21000	NA	NA	NA	NA	NA
Interleukin-12 family signaling	17	NA	NA	0.2450	0.06190	-0.092800	0.158000	-0.098400	-0.11300	NA	NA	NA	NA	NA
Interleukin-12 signaling	15	NA	NA	0.3180	0.06190	-0.092800	0.158000	-0.098400	-0.23200	NA	NA	NA	NA	NA
Interleukin-17 signaling	10	NA	NA	0.3360	-0.22300	NaN	-0.124000	-0.207000	0.07150	NA	NA	NA	NA	NA
Interleukin-3, Interleukin-5 and GM-CSF signaling	5	NA	NA	0.5180	-0.23500	NaN	-0.057200	0.134000	0.43800	NA	NA	NA	NA	NA
Interleukin-4 and Interleukin-13 signaling	22	NA	NA	0.3230	-0.09610	0.021300	-0.058000	-0.133000	0.27100	NA	NA	NA	NA	NA
Interleukin-6 family signaling	5	NA	NA	0.5720	-0.04460	NaN	-0.057200	NaN	0.56700	NA	NA	NA	NA	NA
Intra-Golgi and retrograde Golgi-to-ER traffic	19	NA	NA	0.1410	-0.09610	-0.032200	0.095300	0.022700	0.01160	NA	NA	NA	NA	NA
Intracellular signaling by second messengers	26	NA	NA	0.1560	-0.13600	-0.024700	0.037400	-0.039500	0.04760	NA	NA	NA	NA	NA
Intrinsic Pathway for Apoptosis	7	NA	NA	0.3960	0.11100	0.070900	0.215000	-0.035700	-0.30400	NA	NA	NA	NA	NA
Ion channel transport	17	NA	NA	0.4160	-0.22200	0.152000	-0.074400	-0.000532	0.30800	NA	NA	NA	NA	NA
Ion homeostasis	8	NA	NA	0.4780	-0.22400	0.152000	-0.063100	0.045400	0.38700	NA	NA	NA	NA	NA
Ion transport by P-type ATPases	9	NA	NA	0.4740	-0.22400	0.152000	0.005270	0.045400	0.38700	NA	NA	NA	NA	NA
Iron uptake and transport	9	NA	NA	0.2990	-0.23100	0.167000	-0.043100	-0.076200	0.02490	NA	NA	NA	NA	NA
Josephin domain DUBs	5	NA	NA	0.5450	-0.17100	NaN	-0.188000	-0.207000	-0.43500	NA	NA	NA	NA	NA
Kinesins	9	NA	NA	0.3940	0.31800	-0.072300	0.095300	0.113000	-0.16400	NA	NA	NA	NA	NA
L13a-mediated translational silencing of Ceruloplasmin expression	56	NA	NA	0.3920	0.14300	0.176000	-0.065400	-0.157000	-0.27100	NA	NA	NA	NA	NA
L1CAM interactions	20	NA	NA	0.4040	-0.15900	0.164000	-0.084800	0.010400	0.32300	NA	NA	NA	NA	NA
Lagging Strand Synthesis	5	NA	NA	0.4560	0.30200	-0.079700	0.176000	NaN	-0.28100	NA	NA	NA	NA	NA
Laminin interactions	5	NA	NA	0.5210	-0.20800	0.156000	-0.087400	0.010500	0.44300	NA	NA	NA	NA	NA
Late Phase of HIV Life Cycle	22	NA	NA	0.1570	0.07790	-0.033500	0.046300	-0.028700	-0.12000	NA	NA	NA	NA	NA
Late endosomal microautophagy	7	NA	NA	0.3550	-0.29000	NaN	-0.192000	-0.060600	-0.04110	NA	NA	NA	NA	NA
Leishmania infection	20	NA	NA	0.3200	-0.25600	NaN	-0.077300	0.019500	0.17400	NA	NA	NA	NA	NA
Leishmania parasite growth and survival	9	NA	NA	0.5120	-0.27800	NaN	-0.158000	0.073100	0.39300	NA	NA	NA	NA	NA
Leishmania phagocytosis	8	NA	NA	0.4290	-0.35000	NaN	-0.235000	0.052500	0.06360	NA	NA	NA	NA	NA
Loss of Nlp from mitotic centrosomes	10	NA	NA	0.3000	0.14700	-0.083300	0.099300	-0.130000	-0.18700	NA	NA	NA	NA	NA
Loss of proteins required for interphase microtubule organization from the centrosome	10	NA	NA	0.3000	0.14700	-0.083300	0.099300	-0.130000	-0.18700	NA	NA	NA	NA	NA
Lysosome Vesicle Biogenesis	5	NA	NA	0.3690	-0.26600	NaN	-0.223000	0.108000	-0.06290	NA	NA	NA	NA	NA
M Phase	73	NA	NA	0.4510	0.18700	-0.111000	0.175000	-0.055500	-0.35100	NA	NA	NA	NA	NA
MAP kinase activation	10	NA	NA	0.3360	-0.22300	NaN	-0.124000	-0.207000	0.07150	NA	NA	NA	NA	NA
MAPK family signaling cascades	38	NA	NA	0.1720	-0.08050	0.032200	0.031400	-0.095300	0.11000	NA	NA	NA	NA	NA
MAPK targets/ Nuclear events mediated by MAP kinases	5	NA	NA	0.2880	-0.10700	NaN	-0.059000	NaN	0.26000	NA	NA	NA	NA	NA
MAPK1/MAPK3 signaling	33	NA	NA	0.2120	-0.12500	-0.058000	0.046000	-0.058300	0.14300	NA	NA	NA	NA	NA
MAPK6/MAPK4 signaling	14	NA	NA	0.1990	0.09780	0.032200	-0.004390	-0.104000	-0.13500	NA	NA	NA	NA	NA
MHC class II antigen presentation	20	NA	NA	0.2540	-0.16900	-0.039100	-0.020500	0.024500	0.18300	NA	NA	NA	NA	NA
Macroautophagy	16	NA	NA	0.2970	-0.00595	-0.040200	-0.030200	-0.207000	-0.20700	NA	NA	NA	NA	NA
Meiosis	10	NA	NA	0.3470	0.15800	-0.069100	0.182000	-0.080100	-0.22600	NA	NA	NA	NA	NA
Meiotic recombination	5	NA	NA	0.5470	0.45500	-0.109000	0.176000	NaN	-0.22200	NA	NA	NA	NA	NA
Meiotic synapsis	6	NA	NA	0.3030	0.00919	-0.037800	0.185000	-0.080100	-0.22300	NA	NA	NA	NA	NA
Membrane Trafficking	56	NA	NA	0.2530	-0.22800	0.001330	-0.022800	0.025600	0.10400	NA	NA	NA	NA	NA
Metabolism of carbohydrates	30	NA	NA	0.1790	0.08380	-0.037000	0.012900	-0.008890	-0.15300	NA	NA	NA	NA	NA
Metabolism of fat-soluble vitamins	7	NA	NA	0.5370	-0.34500	0.099800	-0.087400	-0.003940	0.38900	NA	NA	NA	NA	NA
Metabolism of lipids	43	NA	NA	0.1080	-0.06330	0.024100	0.062300	-0.049000	0.02830	NA	NA	NA	NA	NA
Metabolism of non-coding RNA	8	NA	NA	0.6830	0.38300	-0.089800	0.132000	NaN	-0.54200	NA	NA	NA	NA	NA
Metabolism of nucleotides	25	NA	NA	0.4290	0.24800	-0.088700	-0.010300	-0.052500	-0.33400	NA	NA	NA	NA	NA
Metabolism of steroids	13	NA	NA	0.2370	0.13400	-0.014500	0.119000	-0.066600	-0.13900	NA	NA	NA	NA	NA
Metabolism of vitamins and cofactors	27	NA	NA	0.1230	-0.09610	-0.013700	0.004180	-0.044400	0.06140	NA	NA	NA	NA	NA
Metabolism of water-soluble vitamins and cofactors	17	NA	NA	0.2040	0.08520	-0.077500	0.129000	-0.057700	-0.09250	NA	NA	NA	NA	NA
MicroRNA (miRNA) biogenesis	5	NA	NA	0.2720	0.07900	0.077500	0.046000	-0.023000	-0.24400	NA	NA	NA	NA	NA
Mitochondrial biogenesis	18	NA	NA	0.2230	-0.13500	0.007250	0.044700	0.070800	-0.15600	NA	NA	NA	NA	NA
Mitochondrial calcium ion transport	9	NA	NA	0.4710	0.24700	NaN	0.127000	-0.051400	-0.37600	NA	NA	NA	NA	NA
Mitochondrial protein import	24	NA	NA	0.4190	0.18700	0.014100	0.077700	0.045700	-0.36400	NA	NA	NA	NA	NA
Mitochondrial translation	26	NA	NA	0.2740	0.15900	0.030200	-0.065900	0.015000	-0.21000	NA	NA	NA	NA	NA
Mitochondrial translation elongation	26	NA	NA	0.2740	0.15900	0.030200	-0.065900	0.015000	-0.21000	NA	NA	NA	NA	NA
Mitochondrial translation initiation	25	NA	NA	0.2690	0.14400	0.030200	-0.065900	0.015000	-0.21500	NA	NA	NA	NA	NA
Mitochondrial translation termination	25	NA	NA	0.2690	0.14400	0.030200	-0.065900	0.015000	-0.21500	NA	NA	NA	NA	NA
Mitophagy	10	NA	NA	0.3350	0.06650	-0.017100	-0.030200	-0.207000	-0.25300	NA	NA	NA	NA	NA
Mitotic Anaphase	57	NA	NA	0.4640	0.18000	-0.108000	0.193000	-0.029800	-0.36500	NA	NA	NA	NA	NA
Mitotic G1 phase and G1/S transition	43	NA	NA	0.3920	0.24500	-0.094200	0.066900	-0.072600	-0.27400	NA	NA	NA	NA	NA
Mitotic G2-G2/M phases	34	NA	NA	0.3690	0.11600	-0.123000	0.169000	-0.089100	-0.26700	NA	NA	NA	NA	NA
Mitotic Metaphase and Anaphase	57	NA	NA	0.4640	0.18000	-0.108000	0.193000	-0.029800	-0.36500	NA	NA	NA	NA	NA
Mitotic Prometaphase	42	NA	NA	0.4510	0.20700	-0.115000	0.176000	-0.078200	-0.33200	NA	NA	NA	NA	NA
Mitotic Prophase	15	NA	NA	0.4140	0.16300	-0.109000	0.187000	-0.098100	-0.29700	NA	NA	NA	NA	NA
Mitotic Spindle Checkpoint	27	NA	NA	0.4850	0.21000	-0.119000	0.179000	-0.025000	-0.38000	NA	NA	NA	NA	NA
Molecules associated with elastic fibres	6	NA	NA	0.6140	-0.15300	NaN	-0.106000	-0.159000	0.56300	NA	NA	NA	NA	NA
Muscle contraction	21	NA	NA	0.5140	-0.25600	0.118000	-0.133000	-0.027800	0.40800	NA	NA	NA	NA	NA
MyD88 cascade initiated on plasma membrane	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
MyD88 dependent cascade initiated on endosome	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
MyD88-independent TLR4 cascade	13	NA	NA	0.2310	-0.23000	-0.003950	-0.000265	0.001980	-0.02060	NA	NA	NA	NA	NA
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Myogenesis	5	NA	NA	0.4190	-0.17600	NaN	-0.059000	NaN	0.37600	NA	NA	NA	NA	NA
NCAM signaling for neurite out-growth	7	NA	NA	0.4340	-0.26800	NaN	-0.087900	-0.022300	0.32900	NA	NA	NA	NA	NA
NF-kB is activated and signals survival	5	NA	NA	0.3890	-0.27000	NaN	-0.188000	-0.207000	0.01970	NA	NA	NA	NA	NA
NGF-stimulated transcription	8	NA	NA	0.4650	-0.20500	0.080400	-0.255000	-0.021100	0.32000	NA	NA	NA	NA	NA
NIK-->noncanonical NF-kB signaling	9	NA	NA	0.2850	-0.22800	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
NOTCH1 Intracellular Domain Regulates Transcription	9	NA	NA	0.2140	-0.02060	0.085400	0.059300	-0.185000	-0.01710	NA	NA	NA	NA	NA
NOTCH2 Activation and Transmission of Signal to the Nucleus	6	NA	NA	0.3220	-0.15900	NaN	-0.188000	-0.207000	0.00744	NA	NA	NA	NA	NA
NOTCH3 Activation and Transmission of Signal to the Nucleus	7	NA	NA	0.4670	0.21100	-0.121000	-0.188000	-0.207000	-0.28500	NA	NA	NA	NA	NA
NRAGE signals death through JNK	5	NA	NA	0.3490	-0.26000	-0.110000	0.090500	0.089300	0.16100	NA	NA	NA	NA	NA
NRIF signals cell death from the nucleus	6	NA	NA	0.3800	-0.25700	NaN	-0.188000	-0.207000	0.01970	NA	NA	NA	NA	NA
Neddylation	28	NA	NA	0.1320	0.00332	-0.074900	0.078900	-0.075000	-0.00722	NA	NA	NA	NA	NA
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	5	NA	NA	0.6490	-0.23100	NaN	-0.198000	0.086700	0.56700	NA	NA	NA	NA	NA
Negative epigenetic regulation of rRNA expression	7	NA	NA	0.1810	0.08750	0.009880	-0.048000	0.061700	-0.13800	NA	NA	NA	NA	NA
Negative regulation of FGFR1 signaling	6	NA	NA	0.2420	-0.09040	NaN	-0.084800	-0.207000	0.01230	NA	NA	NA	NA	NA
Negative regulation of FGFR2 signaling	5	NA	NA	0.2550	NaN	NaN	-0.084800	-0.207000	-0.12100	NA	NA	NA	NA	NA
Negative regulation of FGFR3 signaling	5	NA	NA	0.2550	NaN	NaN	-0.084800	-0.207000	-0.12100	NA	NA	NA	NA	NA
Negative regulation of FGFR4 signaling	5	NA	NA	0.2550	NaN	NaN	-0.084800	-0.207000	-0.12100	NA	NA	NA	NA	NA
Negative regulation of MAPK pathway	8	NA	NA	0.3990	-0.34900	NaN	0.065900	-0.153000	-0.09980	NA	NA	NA	NA	NA
Negative regulation of NOTCH4 signaling	11	NA	NA	0.2450	-0.12500	-0.070500	0.043400	0.018500	-0.19300	NA	NA	NA	NA	NA
Negative regulation of the PI3K/AKT network	9	NA	NA	0.3140	-0.27300	NaN	0.018400	NaN	0.15400	NA	NA	NA	NA	NA
Nervous system development	126	NA	NA	0.2020	-0.06210	0.160000	-0.083600	-0.055300	0.03550	NA	NA	NA	NA	NA
Netrin-1 signaling	7	NA	NA	0.1430	NaN	NaN	0.018400	0.019800	0.14000	NA	NA	NA	NA	NA
Neurodegenerative Diseases	6	NA	NA	0.4040	-0.12700	0.000881	0.218000	-0.080100	-0.30600	NA	NA	NA	NA	NA
Neuronal System	24	NA	NA	0.3270	-0.05210	0.076400	-0.096100	0.090700	0.28400	NA	NA	NA	NA	NA
Neurotransmitter receptors and postsynaptic signal transmission	13	NA	NA	0.3370	0.03220	0.019700	0.014500	0.090700	0.32200	NA	NA	NA	NA	NA
Neurotransmitter release cycle	6	NA	NA	0.4310	-0.15800	NaN	-0.176000	NaN	0.36000	NA	NA	NA	NA	NA
Neutrophil degranulation	77	NA	NA	0.1390	-0.09280	0.029700	-0.018600	-0.005770	0.09740	NA	NA	NA	NA	NA
NoRC negatively regulates rRNA expression	7	NA	NA	0.1810	0.08750	0.009880	-0.048000	0.061700	-0.13800	NA	NA	NA	NA	NA
Non-integrin membrane-ECM interactions	6	NA	NA	0.5020	-0.27500	0.156000	-0.108000	-0.053300	0.37100	NA	NA	NA	NA	NA
Nonhomologous End-Joining (NHEJ)	6	NA	NA	0.3580	0.23600	0.061700	0.159000	NaN	-0.20800	NA	NA	NA	NA	NA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	55	NA	NA	0.4200	0.19200	0.176000	-0.131000	-0.154000	-0.26000	NA	NA	NA	NA	NA
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	51	NA	NA	0.4230	0.16800	0.184000	-0.131000	-0.156000	-0.27400	NA	NA	NA	NA	NA
Nonsense-Mediated Decay (NMD)	55	NA	NA	0.4200	0.19200	0.176000	-0.131000	-0.154000	-0.26000	NA	NA	NA	NA	NA
Nuclear Envelope (NE) Reassembly	20	NA	NA	0.4630	0.16500	-0.075800	0.220000	-0.026800	-0.36400	NA	NA	NA	NA	NA
Nuclear Envelope Breakdown	9	NA	NA	0.5330	0.19700	-0.116000	0.211000	-0.080100	-0.42500	NA	NA	NA	NA	NA
Nuclear Events (kinase and transcription factor activation)	11	NA	NA	0.4120	-0.18600	0.080400	-0.157000	-0.021100	0.32200	NA	NA	NA	NA	NA
Nuclear Pore Complex (NPC) Disassembly	5	NA	NA	0.5500	0.31500	-0.148000	0.202000	NaN	-0.37500	NA	NA	NA	NA	NA
Nuclear import of Rev protein	6	NA	NA	0.5970	0.20000	0.022300	0.197000	-0.108000	-0.51500	NA	NA	NA	NA	NA
Nuclear signaling by ERBB4	7	NA	NA	0.4170	-0.25200	0.051500	-0.032700	0.002630	0.32700	NA	NA	NA	NA	NA
Nucleobase biosynthesis	6	NA	NA	0.4830	0.22500	-0.038100	NaN	NaN	-0.42600	NA	NA	NA	NA	NA
Nucleosome assembly	13	NA	NA	0.4790	0.12300	-0.109000	0.203000	-0.049900	-0.39800	NA	NA	NA	NA	NA
Nucleotide Excision Repair	21	NA	NA	0.2860	0.17600	-0.062500	0.023600	-0.006440	-0.21500	NA	NA	NA	NA	NA
Oncogene Induced Senescence	9	NA	NA	0.2110	0.02630	0.131000	-0.019200	-0.155000	0.04840	NA	NA	NA	NA	NA
Oncogenic MAPK signaling	11	NA	NA	0.2590	-0.17300	0.112000	0.112000	-0.110000	-0.01320	NA	NA	NA	NA	NA
Opioid Signalling	6	NA	NA	0.3120	-0.13300	0.019700	-0.094500	-0.031500	0.26300	NA	NA	NA	NA	NA
Orc1 removal from chromatin	17	NA	NA	0.4280	0.26700	-0.103000	0.048600	-0.039500	-0.31300	NA	NA	NA	NA	NA
Organelle biogenesis and maintenance	39	NA	NA	0.1740	0.01400	-0.048400	0.081100	-0.005550	-0.14500	NA	NA	NA	NA	NA
Oxidative Stress Induced Senescence	14	NA	NA	0.2370	0.02720	0.029000	-0.019200	-0.207000	-0.10700	NA	NA	NA	NA	NA
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	10	NA	NA	0.0657	-0.00262	-0.019700	0.043400	-0.039500	0.02190	NA	NA	NA	NA	NA
PCNA-Dependent Long Patch Base Excision Repair	6	NA	NA	0.4240	0.25300	-0.079700	0.176000	NaN	-0.28100	NA	NA	NA	NA	NA
PCP/CE pathway	15	NA	NA	0.2160	0.19200	-0.019700	-0.045700	0.014500	-0.08450	NA	NA	NA	NA	NA
PERK regulates gene expression	5	NA	NA	0.3620	0.27000	-0.061700	0.219000	NaN	-0.08050	NA	NA	NA	NA	NA
PI3K/AKT Signaling in Cancer	9	NA	NA	0.3190	-0.27300	NaN	0.071000	NaN	0.14800	NA	NA	NA	NA	NA
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	9	NA	NA	0.3140	-0.27300	NaN	0.018400	NaN	0.15400	NA	NA	NA	NA	NA
PINK1-PRKN Mediated Mitophagy	10	NA	NA	0.3350	0.06650	-0.017100	-0.030200	-0.207000	-0.25300	NA	NA	NA	NA	NA
PIP3 activates AKT signaling	23	NA	NA	0.1550	-0.12500	-0.046800	0.063800	-0.039500	0.02270	NA	NA	NA	NA	NA
PIWI-interacting RNA (piRNA) biogenesis	6	NA	NA	0.2510	0.13400	0.007250	0.042100	-0.036200	-0.20500	NA	NA	NA	NA	NA
PRC2 methylates histones and DNA	5	NA	NA	0.2760	0.06160	-0.065900	NaN	NaN	-0.26100	NA	NA	NA	NA	NA
PTEN Regulation	13	NA	NA	0.1300	-0.02540	-0.046800	0.058400	-0.039500	-0.09470	NA	NA	NA	NA	NA
Paradoxical activation of RAF signaling by kinase inactive BRAF	6	NA	NA	0.2330	-0.20800	NaN	0.097100	NaN	0.03920	NA	NA	NA	NA	NA
Parasite infection	8	NA	NA	0.4290	-0.35000	NaN	-0.235000	0.052500	0.06360	NA	NA	NA	NA	NA
Pausing and recovery of HIV elongation	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Pausing and recovery of Tat-mediated HIV elongation	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Peptide chain elongation	50	NA	NA	0.4240	0.17300	0.186000	-0.131000	-0.159000	-0.26900	NA	NA	NA	NA	NA
Peptide hormone metabolism	9	NA	NA	0.2430	-0.23300	-0.024900	NaN	0.059000	0.02300	NA	NA	NA	NA	NA
Phase II - Conjugation of compounds	10	NA	NA	0.1820	0.04540	NaN	0.092500	-0.096100	-0.11500	NA	NA	NA	NA	NA
Phospholipid metabolism	9	NA	NA	0.1700	-0.09570	NaN	0.053000	-0.053700	0.11800	NA	NA	NA	NA	NA
Phosphorylation of the APC/C	5	NA	NA	0.5480	0.23100	-0.150000	0.193000	NaN	-0.43200	NA	NA	NA	NA	NA
Plasma lipoprotein assembly, remodeling, and clearance	10	NA	NA	0.4020	-0.17300	0.138000	-0.060600	0.122000	0.30700	NA	NA	NA	NA	NA
Plasma lipoprotein clearance	7	NA	NA	0.3580	-0.12100	0.105000	-0.003290	0.122000	0.29600	NA	NA	NA	NA	NA
Platelet activation, signaling and aggregation	38	NA	NA	0.4590	-0.27400	0.167000	-0.084500	0.043600	0.31400	NA	NA	NA	NA	NA
Platelet degranulation	27	NA	NA	0.5290	-0.34000	0.167000	-0.097800	0.050600	0.35200	NA	NA	NA	NA	NA
Platelet homeostasis	10	NA	NA	0.5030	-0.25100	NaN	-0.076900	-0.055300	0.42500	NA	NA	NA	NA	NA
Polo-like kinase mediated events	5	NA	NA	0.6340	0.25500	-0.162000	0.258000	NaN	-0.49500	NA	NA	NA	NA	NA
Post-chaperonin tubulin folding pathway	7	NA	NA	0.5350	0.32200	-0.045100	0.182000	0.018500	-0.38200	NA	NA	NA	NA	NA
Post-translational modification: synthesis of GPI-anchored proteins	7	NA	NA	0.3710	-0.20100	0.185000	-0.156000	0.057300	0.18900	NA	NA	NA	NA	NA
Postmitotic nuclear pore complex (NPC) reformation	5	NA	NA	0.4000	0.19300	0.022300	0.198000	-0.108000	-0.26700	NA	NA	NA	NA	NA
Potential therapeutics for SARS	21	NA	NA	0.0880	0.04590	-0.026300	0.022000	0.056600	-0.03520	NA	NA	NA	NA	NA
Pre-NOTCH Expression and Processing	5	NA	NA	0.1860	0.18200	NaN	-0.035400	NaN	-0.02000	NA	NA	NA	NA	NA
Prefoldin mediated transfer of substrate to CCT/TriC	17	NA	NA	0.2770	0.15400	0.008250	0.166000	-0.022200	-0.15700	NA	NA	NA	NA	NA
Processing of Capped Intron-Containing Pre-mRNA	60	NA	NA	0.3970	0.21800	-0.038900	0.098300	-0.002920	-0.31400	NA	NA	NA	NA	NA
Processing of Capped Intronless Pre-mRNA	6	NA	NA	0.5730	0.35500	-0.062300	0.147000	NaN	-0.42000	NA	NA	NA	NA	NA
Processing of DNA double-strand break ends	11	NA	NA	0.4400	0.27200	-0.094800	-0.000439	-0.207000	-0.26000	NA	NA	NA	NA	NA
Processing of SMDT1	5	NA	NA	0.5650	0.27300	NaN	NaN	-0.051400	-0.49200	NA	NA	NA	NA	NA
Programmed Cell Death	29	NA	NA	0.1910	-0.02760	-0.038900	0.148000	-0.061700	-0.09260	NA	NA	NA	NA	NA
Protein folding	22	NA	NA	0.2800	0.19100	-0.013600	0.127000	-0.024200	-0.15900	NA	NA	NA	NA	NA
Protein localization	30	NA	NA	0.3550	0.13700	0.014100	0.005330	0.025300	-0.32700	NA	NA	NA	NA	NA
Protein methylation	8	NA	NA	0.2900	0.12600	0.202000	-0.121000	-0.111000	-0.02500	NA	NA	NA	NA	NA
Protein ubiquitination	12	NA	NA	0.2750	0.04790	-0.162000	-0.056700	-0.115000	-0.17600	NA	NA	NA	NA	NA
Protein-protein interactions at synapses	5	NA	NA	0.4670	-0.25100	0.133000	-0.095800	NaN	0.35800	NA	NA	NA	NA	NA
Purine ribonucleoside monophosphate biosynthesis	5	NA	NA	0.4840	0.22600	-0.038100	NaN	NaN	-0.42600	NA	NA	NA	NA	NA
Pyruvate metabolism	5	NA	NA	0.3660	0.18200	NaN	0.127000	NaN	-0.29100	NA	NA	NA	NA	NA
Pyruvate metabolism and Citric Acid (TCA) cycle	9	NA	NA	0.3660	0.15000	-0.056500	0.127000	NaN	-0.30400	NA	NA	NA	NA	NA
RAB GEFs exchange GTP for GDP on RABs	6	NA	NA	0.2430	-0.17000	NaN	NaN	NaN	0.17400	NA	NA	NA	NA	NA
RAB geranylgeranylation	5	NA	NA	0.3570	-0.30200	NaN	NaN	-0.018400	0.19000	NA	NA	NA	NA	NA
RAF activation	7	NA	NA	0.1960	-0.17200	NaN	0.074300	-0.053800	0.01890	NA	NA	NA	NA	NA
RAF-independent MAPK1/3 activation	7	NA	NA	0.3670	0.09780	-0.095900	-0.057200	-0.098500	0.32100	NA	NA	NA	NA	NA
RAF/MAP kinase cascade	30	NA	NA	0.2300	-0.16200	-0.019700	0.049300	-0.058300	0.14300	NA	NA	NA	NA	NA
RET signaling	5	NA	NA	0.2360	NaN	NaN	-0.046700	NaN	0.23100	NA	NA	NA	NA	NA
RHO GTPase Effectors	48	NA	NA	0.2090	-0.05730	-0.107000	0.106000	0.017200	-0.13100	NA	NA	NA	NA	NA
RHO GTPases Activate Formins	32	NA	NA	0.3300	0.12000	-0.111000	0.139000	-0.022000	-0.25000	NA	NA	NA	NA	NA
RHO GTPases Activate WASPs and WAVEs	6	NA	NA	0.4220	-0.35000	NaN	-0.235000	NaN	-0.00854	NA	NA	NA	NA	NA
RHO GTPases activate CIT	5	NA	NA	0.4520	-0.35100	NaN	-0.061900	-0.015800	0.27700	NA	NA	NA	NA	NA
RHO GTPases activate PKNs	8	NA	NA	0.3330	-0.30700	NaN	-0.050500	0.059300	0.10300	NA	NA	NA	NA	NA
RIPK1-mediated regulated necrosis	6	NA	NA	0.3000	-0.10200	0.034900	-0.188000	-0.207000	-0.01740	NA	NA	NA	NA	NA
RMTs methylate histone arginines	8	NA	NA	0.3280	0.16100	NaN	0.092700	-0.185000	-0.19700	NA	NA	NA	NA	NA
RNA Pol II CTD phosphorylation and interaction with CE	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
RNA Polymerase I Promoter Clearance	8	NA	NA	0.2040	0.09380	0.077500	0.049600	0.061700	-0.14400	NA	NA	NA	NA	NA
RNA Polymerase I Promoter Escape	6	NA	NA	0.2450	0.09380	0.077500	0.030200	0.061700	-0.20200	NA	NA	NA	NA	NA
RNA Polymerase I Transcription	8	NA	NA	0.2040	0.09380	0.077500	0.049600	0.061700	-0.14400	NA	NA	NA	NA	NA
RNA Polymerase I Transcription Initiation	6	NA	NA	0.1730	0.09380	0.077500	-0.048000	0.061700	-0.09420	NA	NA	NA	NA	NA
RNA Polymerase II HIV Promoter Escape	6	NA	NA	0.2330	0.07050	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
RNA Polymerase II Pre-transcription Events	9	NA	NA	0.2340	0.11500	0.015000	-0.184000	0.043500	-0.07540	NA	NA	NA	NA	NA
RNA Polymerase II Promoter Escape	6	NA	NA	0.2330	0.07050	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
RNA Polymerase II Transcription Elongation	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
RNA Polymerase II Transcription Initiation	6	NA	NA	0.2330	0.07050	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
RNA Polymerase II Transcription Initiation And Promoter Clearance	6	NA	NA	0.2330	0.07050	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	6	NA	NA	0.2330	0.07050	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
RNA Polymerase II Transcription Termination	18	NA	NA	0.4650	0.25700	-0.040400	0.122000	-0.122000	-0.34500	NA	NA	NA	NA	NA
RNA Polymerase III Abortive And Retractive Initiation	7	NA	NA	0.3680	0.16400	0.042200	0.035600	-0.036900	-0.32300	NA	NA	NA	NA	NA
RNA Polymerase III Chain Elongation	5	NA	NA	0.3870	0.16400	0.042200	-0.184000	0.061700	-0.28900	NA	NA	NA	NA	NA
RNA Polymerase III Transcription	7	NA	NA	0.3680	0.16400	0.042200	0.035600	-0.036900	-0.32300	NA	NA	NA	NA	NA
RNA Polymerase III Transcription Initiation	6	NA	NA	0.3810	0.16400	0.042200	-0.015100	-0.036900	-0.33800	NA	NA	NA	NA	NA
RNA Polymerase III Transcription Initiation From Type 1 Promoter	6	NA	NA	0.3810	0.16400	0.042200	-0.015100	-0.036900	-0.33800	NA	NA	NA	NA	NA
RNA Polymerase III Transcription Initiation From Type 2 Promoter	5	NA	NA	0.3870	0.16400	0.042200	-0.184000	0.061700	-0.28900	NA	NA	NA	NA	NA
RNA Polymerase III Transcription Initiation From Type 3 Promoter	5	NA	NA	0.3870	0.16400	0.042200	-0.184000	0.061700	-0.28900	NA	NA	NA	NA	NA
RNA Polymerase III Transcription Termination	6	NA	NA	0.3330	0.16400	0.042200	-0.023700	0.061700	-0.27900	NA	NA	NA	NA	NA
RNA polymerase II transcribes snRNA genes	7	NA	NA	0.2270	0.04770	0.038200	-0.184000	0.043500	-0.11000	NA	NA	NA	NA	NA
RUNX1 regulates transcription of genes involved in differentiation of HSCs	10	NA	NA	0.1300	-0.00262	-0.019700	0.043400	-0.039500	-0.11400	NA	NA	NA	NA	NA
Rab regulation of trafficking	8	NA	NA	0.2170	-0.17000	NaN	NaN	-0.087600	0.10300	NA	NA	NA	NA	NA
Recognition of DNA damage by PCNA-containing replication complex	9	NA	NA	0.4020	0.19800	-0.071600	-0.005920	-0.207000	-0.27200	NA	NA	NA	NA	NA
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	8	NA	NA	0.3610	0.18000	0.053800	-0.074300	-0.207000	-0.21600	NA	NA	NA	NA	NA
Recruitment of NuMA to mitotic centrosomes	12	NA	NA	0.3190	0.15900	-0.080500	0.111000	-0.130000	-0.20100	NA	NA	NA	NA	NA
Recruitment of mitotic centrosome proteins and complexes	12	NA	NA	0.3190	0.15900	-0.080500	0.111000	-0.130000	-0.20100	NA	NA	NA	NA	NA
Recycling pathway of L1	5	NA	NA	0.3920	NaN	NaN	NaN	0.012300	0.39100	NA	NA	NA	NA	NA
Regulated Necrosis	6	NA	NA	0.3000	-0.10200	0.034900	-0.188000	-0.207000	-0.01740	NA	NA	NA	NA	NA
Regulation of APC/C activators between G1/S and early anaphase	18	NA	NA	0.4330	0.15600	-0.140000	0.139000	-0.039500	-0.35000	NA	NA	NA	NA	NA
Regulation of Apoptosis	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Regulation of HSF1-mediated heat shock response	12	NA	NA	0.3600	0.24100	0.014500	0.100000	0.143000	-0.20300	NA	NA	NA	NA	NA
Regulation of MECP2 expression and activity	6	NA	NA	0.3340	-0.20500	-0.051200	0.125000	-0.206000	0.09520	NA	NA	NA	NA	NA
Regulation of PLK1 Activity at G2/M Transition	17	NA	NA	0.3560	0.10200	-0.103000	0.111000	-0.157000	-0.26200	NA	NA	NA	NA	NA
Regulation of PTEN gene transcription	5	NA	NA	0.1280	-0.03670	-0.073500	0.087900	NaN	-0.04230	NA	NA	NA	NA	NA
Regulation of PTEN stability and activity	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Regulation of RAS by GAPs	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Regulation of RUNX1 Expression and Activity	5	NA	NA	0.2510	-0.17700	0.060400	-0.048900	NaN	0.16100	NA	NA	NA	NA	NA
Regulation of RUNX2 expression and activity	11	NA	NA	0.2370	-0.22800	-0.019700	0.043400	-0.039500	-0.02020	NA	NA	NA	NA	NA
Regulation of RUNX3 expression and activity	11	NA	NA	0.1510	-0.00262	-0.019700	0.070300	-0.090300	-0.09700	NA	NA	NA	NA	NA
Regulation of TP53 Activity	19	NA	NA	0.3490	0.23300	-0.095600	0.084900	-0.138000	-0.18000	NA	NA	NA	NA	NA
Regulation of TP53 Activity through Phosphorylation	14	NA	NA	0.4300	0.23100	-0.095000	0.084000	-0.138000	-0.31100	NA	NA	NA	NA	NA
Regulation of TP53 Degradation	8	NA	NA	0.4050	0.30300	-0.125000	-0.018000	-0.207000	-0.11500	NA	NA	NA	NA	NA
Regulation of TP53 Expression and Degradation	8	NA	NA	0.4050	0.30300	-0.125000	-0.018000	-0.207000	-0.11500	NA	NA	NA	NA	NA
Regulation of actin dynamics for phagocytic cup formation	9	NA	NA	0.1720	-0.01440	-0.063000	0.003950	-0.034200	-0.15600	NA	NA	NA	NA	NA
Regulation of activated PAK-2p34 by proteasome mediated degradation	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Regulation of cholesterol biosynthesis by SREBP (SREBF)	5	NA	NA	0.4710	0.07490	0.022300	0.276000	-0.106000	-0.35800	NA	NA	NA	NA	NA
Regulation of expression of SLITs and ROBOs	63	NA	NA	0.3620	0.18000	0.168000	-0.096700	-0.137000	-0.20600	NA	NA	NA	NA	NA
Regulation of insulin secretion	6	NA	NA	0.3770	-0.10800	NaN	-0.015700	-0.106000	0.34500	NA	NA	NA	NA	NA
Regulation of mRNA stability by proteins that bind AU-rich elements	19	NA	NA	0.2500	0.09380	-0.035100	0.086900	-0.015200	-0.21200	NA	NA	NA	NA	NA
Regulation of mitotic cell cycle	20	NA	NA	0.4410	0.15600	-0.137000	0.153000	-0.039500	-0.35500	NA	NA	NA	NA	NA
Regulation of necroptotic cell death	6	NA	NA	0.3000	-0.10200	0.034900	-0.188000	-0.207000	-0.01740	NA	NA	NA	NA	NA
Reproduction	11	NA	NA	0.2770	0.05030	-0.069100	0.133000	-0.023000	-0.22600	NA	NA	NA	NA	NA
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	7	NA	NA	0.4520	0.28400	-0.097500	0.112000	NaN	-0.31800	NA	NA	NA	NA	NA
Resolution of Abasic Sites (AP sites)	9	NA	NA	0.4170	0.28400	-0.097500	0.018900	NaN	-0.28900	NA	NA	NA	NA	NA
Resolution of Sister Chromatid Cohesion	30	NA	NA	0.4820	0.22500	-0.114000	0.194000	-0.025000	-0.36100	NA	NA	NA	NA	NA
Respiratory electron transport	25	NA	NA	0.3830	-0.05310	0.042800	-0.056100	0.095300	-0.36100	NA	NA	NA	NA	NA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	34	NA	NA	0.3690	-0.11500	0.042800	-0.080800	0.104000	-0.32200	NA	NA	NA	NA	NA
Response of EIF2AK4 (GCN2) to amino acid deficiency	51	NA	NA	0.3930	0.15200	0.184000	-0.092200	-0.156000	-0.25400	NA	NA	NA	NA	NA
Response of Mtb to phagocytosis	7	NA	NA	0.4480	0.15200	0.033600	0.051400	-0.207000	-0.36200	NA	NA	NA	NA	NA
Response to elevated platelet cytosolic Ca2+	27	NA	NA	0.5290	-0.34000	0.167000	-0.097800	0.050600	0.35200	NA	NA	NA	NA	NA
Retinoid metabolism and transport	7	NA	NA	0.5370	-0.34500	0.099800	-0.087400	-0.003940	0.38900	NA	NA	NA	NA	NA
Rev-mediated nuclear export of HIV RNA	6	NA	NA	0.7900	0.29300	-0.177000	0.190000	-0.108000	-0.67700	NA	NA	NA	NA	NA
Rho GTPase cycle	9	NA	NA	0.2170	-0.02940	0.030300	-0.111000	0.036900	0.17800	NA	NA	NA	NA	NA
Ribosomal scanning and start codon recognition	26	NA	NA	0.3700	0.12600	0.159000	0.086600	-0.127000	-0.26800	NA	NA	NA	NA	NA
S Phase	34	NA	NA	0.4830	0.28900	-0.102000	0.099600	-0.072600	-0.35200	NA	NA	NA	NA	NA
SARS-CoV Infections	29	NA	NA	0.0509	-0.02870	-0.026300	0.019200	0.020400	-0.01700	NA	NA	NA	NA	NA
SARS-CoV-1 Infection	6	NA	NA	0.3170	-0.14000	NaN	-0.188000	-0.207000	-0.05210	NA	NA	NA	NA	NA
SARS-CoV-2 Infection	9	NA	NA	0.2840	-0.26700	NaN	0.008550	-0.052000	0.08180	NA	NA	NA	NA	NA
SCF(Skp2)-mediated degradation of p27/p21	13	NA	NA	0.2690	0.02830	-0.126000	0.058300	-0.039500	-0.22500	NA	NA	NA	NA	NA
SCF-beta-TrCP mediated degradation of Emi1	10	NA	NA	0.2440	-0.08540	-0.079700	0.101000	-0.039500	-0.18400	NA	NA	NA	NA	NA
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	5	NA	NA	0.4100	-0.32200	NaN	-0.074800	NaN	0.24300	NA	NA	NA	NA	NA
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	6	NA	NA	0.5730	0.35500	-0.062300	0.147000	NaN	-0.42000	NA	NA	NA	NA	NA
SLBP independent Processing of Histone Pre-mRNAs	5	NA	NA	0.6480	0.35700	-0.086300	0.147000	NaN	-0.51300	NA	NA	NA	NA	NA
SLC transporter disorders	6	NA	NA	0.2090	0.09510	NaN	0.086600	0.156000	0.05120	NA	NA	NA	NA	NA
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	7	NA	NA	0.3290	0.19900	0.109000	-0.107000	-0.173000	-0.12400	NA	NA	NA	NA	NA
SRP-dependent cotranslational protein targeting to membrane	57	NA	NA	0.3640	0.03160	0.184000	-0.074200	-0.085300	-0.29100	NA	NA	NA	NA	NA
SUMO E3 ligases SUMOylate target proteins	23	NA	NA	0.4320	0.22100	-0.102000	0.139000	-0.217000	-0.24600	NA	NA	NA	NA	NA
SUMOylation	25	NA	NA	0.4240	0.22100	-0.100000	0.131000	-0.217000	-0.23800	NA	NA	NA	NA	NA
SUMOylation of DNA damage response and repair proteins	6	NA	NA	0.4050	0.32100	-0.084100	0.095800	NaN	-0.21100	NA	NA	NA	NA	NA
SUMOylation of DNA replication proteins	9	NA	NA	0.4500	0.28000	-0.124000	0.161000	NaN	-0.28800	NA	NA	NA	NA	NA
SUMOylation of RNA binding proteins	5	NA	NA	0.3730	0.31800	NaN	0.086600	NaN	-0.17400	NA	NA	NA	NA	NA
SUMOylation of transcription cofactors	6	NA	NA	0.3750	0.04600	NaN	0.133000	-0.217000	-0.27100	NA	NA	NA	NA	NA
Scavenging by Class A Receptors	5	NA	NA	0.6330	-0.35400	0.167000	-0.073500	NaN	0.49200	NA	NA	NA	NA	NA
Sealing of the nuclear envelope (NE) by ESCRT-III	8	NA	NA	0.4600	0.17100	-0.045100	0.182000	0.018500	-0.38200	NA	NA	NA	NA	NA
Selective autophagy	15	NA	NA	0.3020	0.05550	-0.040200	-0.030200	-0.207000	-0.20700	NA	NA	NA	NA	NA
Selenoamino acid metabolism	51	NA	NA	0.3940	0.16200	0.184000	-0.093100	-0.156000	-0.25000	NA	NA	NA	NA	NA
Selenocysteine synthesis	48	NA	NA	0.4290	0.16200	0.184000	-0.131000	-0.156000	-0.28600	NA	NA	NA	NA	NA
Sema4D in semaphorin signaling	5	NA	NA	0.5230	-0.34400	NaN	-0.158000	-0.015800	0.36000	NA	NA	NA	NA	NA
Semaphorin interactions	16	NA	NA	0.3550	-0.23200	-0.063000	-0.061300	0.022100	0.25300	NA	NA	NA	NA	NA
Separation of Sister Chromatids	38	NA	NA	0.4560	0.19100	-0.114000	0.172000	-0.032500	-0.35700	NA	NA	NA	NA	NA
Signaling by BRAF and RAF fusions	8	NA	NA	0.4050	-0.26300	0.112000	0.131000	-0.137000	0.21600	NA	NA	NA	NA	NA
Signaling by EGFR	8	NA	NA	0.3090	NaN	NaN	-0.084800	-0.207000	0.21300	NA	NA	NA	NA	NA
Signaling by EGFR in Cancer	5	NA	NA	0.4610	0.32100	-0.063000	-0.188000	-0.207000	-0.16600	NA	NA	NA	NA	NA
Signaling by ERBB2	7	NA	NA	0.4590	0.32100	-0.063000	-0.188000	-0.207000	-0.16000	NA	NA	NA	NA	NA
Signaling by ERBB4	12	NA	NA	0.2810	-0.25200	0.051500	-0.055300	-0.067800	0.07400	NA	NA	NA	NA	NA
Signaling by FGFR	16	NA	NA	0.1840	0.08510	0.077500	-0.118000	-0.073100	-0.03640	NA	NA	NA	NA	NA
Signaling by FGFR in disease	7	NA	NA	0.2200	0.02980	0.077500	-0.184000	0.061700	-0.06190	NA	NA	NA	NA	NA
Signaling by FGFR1	7	NA	NA	0.2560	-0.09040	NaN	-0.084800	-0.207000	0.08310	NA	NA	NA	NA	NA
Signaling by FGFR2	15	NA	NA	0.2110	0.12000	0.077500	-0.118000	-0.073100	-0.06800	NA	NA	NA	NA	NA
Signaling by FGFR2 IIIa TM	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
Signaling by FGFR2 in disease	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
Signaling by FGFR3	6	NA	NA	0.2250	NaN	NaN	-0.084800	-0.207000	0.01790	NA	NA	NA	NA	NA
Signaling by FGFR4	6	NA	NA	0.2250	NaN	NaN	-0.084800	-0.207000	0.01790	NA	NA	NA	NA	NA
Signaling by Hedgehog	12	NA	NA	0.3310	-0.30500	-0.019700	0.043400	-0.039500	0.11300	NA	NA	NA	NA	NA
Signaling by Insulin receptor	6	NA	NA	0.4130	-0.15000	NaN	-0.089400	0.152000	0.34300	NA	NA	NA	NA	NA
Signaling by Interleukins	62	NA	NA	0.1500	-0.09230	-0.025100	0.059000	-0.059200	0.08030	NA	NA	NA	NA	NA
Signaling by Ligand-Responsive EGFR Variants in Cancer	5	NA	NA	0.4610	0.32100	-0.063000	-0.188000	-0.207000	-0.16600	NA	NA	NA	NA	NA
Signaling by MET	10	NA	NA	0.3410	-0.23800	0.156000	-0.101000	-0.061900	0.14400	NA	NA	NA	NA	NA
Signaling by NOTCH	29	NA	NA	0.1480	0.02150	-0.013600	0.115000	-0.058500	-0.06780	NA	NA	NA	NA	NA
Signaling by NOTCH1	12	NA	NA	0.2300	-0.07270	0.085400	0.059300	-0.185000	0.05120	NA	NA	NA	NA	NA
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	10	NA	NA	0.2250	-0.07270	0.085400	0.059300	-0.185000	-0.01530	NA	NA	NA	NA	NA
Signaling by NOTCH1 PEST Domain Mutants in Cancer	10	NA	NA	0.2250	-0.07270	0.085400	0.059300	-0.185000	-0.01530	NA	NA	NA	NA	NA
Signaling by NOTCH1 in Cancer	10	NA	NA	0.2250	-0.07270	0.085400	0.059300	-0.185000	-0.01530	NA	NA	NA	NA	NA
Signaling by NOTCH2	6	NA	NA	0.3220	-0.15900	NaN	-0.188000	-0.207000	0.00744	NA	NA	NA	NA	NA
Signaling by NOTCH3	11	NA	NA	0.2870	0.11800	-0.044500	0.063700	-0.207000	-0.14000	NA	NA	NA	NA	NA
Signaling by NOTCH4	14	NA	NA	0.1690	-0.14600	-0.070500	0.043400	0.018500	-0.01340	NA	NA	NA	NA	NA
Signaling by NTRK1 (TRKA)	17	NA	NA	0.4130	-0.22700	0.080400	-0.022800	0.026900	0.33300	NA	NA	NA	NA	NA
Signaling by NTRKs	21	NA	NA	0.3850	-0.22700	0.080400	-0.012600	0.026900	0.29900	NA	NA	NA	NA	NA
Signaling by Non-Receptor Tyrosine Kinases	11	NA	NA	0.2440	0.11700	0.044600	-0.009230	-0.207000	-0.02950	NA	NA	NA	NA	NA
Signaling by PDGF	11	NA	NA	0.4890	-0.29600	0.118000	-0.073400	-0.022300	0.36200	NA	NA	NA	NA	NA
Signaling by PTK6	11	NA	NA	0.2440	0.11700	0.044600	-0.009230	-0.207000	-0.02950	NA	NA	NA	NA	NA
Signaling by RAS mutants	6	NA	NA	0.2330	-0.20800	NaN	0.097100	NaN	0.03920	NA	NA	NA	NA	NA
Signaling by ROBO receptors	68	NA	NA	0.3360	0.15400	0.168000	-0.090400	-0.129000	-0.19100	NA	NA	NA	NA	NA
Signaling by Receptor Tyrosine Kinases	69	NA	NA	0.3340	-0.18400	0.073300	-0.088600	0.015800	0.25400	NA	NA	NA	NA	NA
Signaling by Retinoic Acid	7	NA	NA	0.4330	0.00832	NaN	NaN	0.167000	0.39900	NA	NA	NA	NA	NA
Signaling by Rho GTPases	55	NA	NA	0.1660	-0.04700	-0.095900	0.093700	0.031900	-0.08040	NA	NA	NA	NA	NA
Signaling by TGF-beta Receptor Complex	18	NA	NA	0.2160	0.11600	0.021200	0.036900	-0.119000	-0.13100	NA	NA	NA	NA	NA
Signaling by TGFB family members	22	NA	NA	0.1660	0.09920	0.034100	0.016900	-0.119000	0.04680	NA	NA	NA	NA	NA
Signaling by VEGF	11	NA	NA	0.2970	-0.14900	0.023100	-0.139000	NaN	0.21500	NA	NA	NA	NA	NA
Signaling by WNT	35	NA	NA	0.1450	-0.01230	0.074900	-0.082300	-0.040100	0.08290	NA	NA	NA	NA	NA
Signaling by moderate kinase activity BRAF mutants	6	NA	NA	0.2330	-0.20800	NaN	0.097100	NaN	0.03920	NA	NA	NA	NA	NA
Signaling by the B Cell Receptor (BCR)	15	NA	NA	0.2850	-0.27000	0.063900	0.042900	-0.008370	0.04540	NA	NA	NA	NA	NA
Signaling downstream of RAS mutants	6	NA	NA	0.2330	-0.20800	NaN	0.097100	NaN	0.03920	NA	NA	NA	NA	NA
Smooth Muscle Contraction	11	NA	NA	0.5620	-0.27000	0.100000	-0.150000	-0.064700	0.45500	NA	NA	NA	NA	NA
Spry regulation of FGF signaling	5	NA	NA	0.2550	NaN	NaN	-0.084800	-0.207000	-0.12100	NA	NA	NA	NA	NA
Stabilization of p53	9	NA	NA	0.1800	-0.00262	-0.019700	0.070300	-0.039500	-0.15900	NA	NA	NA	NA	NA
Stimuli-sensing channels	8	NA	NA	0.4230	-0.35300	NaN	-0.141000	-0.123000	0.13900	NA	NA	NA	NA	NA
Switching of origins to a post-replicative state	19	NA	NA	0.4670	0.25900	-0.120000	0.077000	-0.039500	-0.36000	NA	NA	NA	NA	NA
Synthesis of DNA	27	NA	NA	0.4730	0.27300	-0.113000	0.091600	-0.039500	-0.35600	NA	NA	NA	NA	NA
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	7	NA	NA	0.4740	0.11500	-0.180000	0.025500	-0.207000	-0.36800	NA	NA	NA	NA	NA
TCF dependent signaling in response to WNT	24	NA	NA	0.1330	0.04420	0.074900	-0.042900	-0.068400	0.06060	NA	NA	NA	NA	NA
TCR signaling	14	NA	NA	0.2370	-0.22800	-0.019700	0.043400	-0.039500	0.00103	NA	NA	NA	NA	NA
TGF-beta receptor signaling activates SMADs	12	NA	NA	0.1620	-0.00876	0.015800	-0.026800	-0.091100	-0.13100	NA	NA	NA	NA	NA
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	5	NA	NA	0.4880	NaN	NaN	-0.188000	-0.115000	-0.43500	NA	NA	NA	NA	NA
TNFR2 non-canonical NF-kB pathway	11	NA	NA	0.2140	-0.12300	0.043500	0.006150	-0.058600	-0.15900	NA	NA	NA	NA	NA
TP53 Regulates Metabolic Genes	11	NA	NA	0.5360	-0.17900	0.060600	0.215000	0.156000	-0.42600	NA	NA	NA	NA	NA
TP53 Regulates Transcription of Cell Cycle Genes	10	NA	NA	0.4050	0.18600	-0.117000	0.134000	NaN	-0.31300	NA	NA	NA	NA	NA
TP53 Regulates Transcription of Cell Death Genes	7	NA	NA	0.2020	0.05490	-0.000659	0.050900	-0.151000	-0.11200	NA	NA	NA	NA	NA
TP53 Regulates Transcription of DNA Repair Genes	11	NA	NA	0.1450	0.08470	-0.029100	-0.037500	0.061700	-0.08910	NA	NA	NA	NA	NA
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	7	NA	NA	0.3730	0.22900	-0.107000	0.140000	NaN	-0.23500	NA	NA	NA	NA	NA
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
TRIF(TICAM1)-mediated TLR4 signaling	13	NA	NA	0.2310	-0.23000	-0.003950	-0.000265	0.001980	-0.02060	NA	NA	NA	NA	NA
Tat-mediated HIV elongation arrest and recovery	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Tat-mediated elongation of the HIV-1 transcript	8	NA	NA	0.2410	0.11500	0.023100	-0.184000	0.061700	-0.08340	NA	NA	NA	NA	NA
Telomere C-strand (Lagging Strand) Synthesis	5	NA	NA	0.4560	0.30200	-0.079700	0.176000	NaN	-0.28100	NA	NA	NA	NA	NA
Telomere Extension By Telomerase	5	NA	NA	0.4750	0.33100	-0.044800	0.019100	0.068300	-0.33000	NA	NA	NA	NA	NA
Telomere Maintenance	15	NA	NA	0.3490	0.23600	-0.042300	0.007600	0.065200	-0.24500	NA	NA	NA	NA	NA
Termination of translesion DNA synthesis	9	NA	NA	0.5170	0.27900	-0.104000	-0.005920	-0.207000	-0.36800	NA	NA	NA	NA	NA
The citric acid (TCA) cycle and respiratory electron transport	42	NA	NA	0.3610	-0.06770	0.009690	-0.046000	0.104000	-0.33600	NA	NA	NA	NA	NA
The role of GTSE1 in G2/M progression after G2 checkpoint	16	NA	NA	0.4510	0.23800	-0.116000	0.168000	-0.066900	-0.31700	NA	NA	NA	NA	NA
The role of Nef in HIV-1 replication and disease pathogenesis	7	NA	NA	0.4910	-0.23100	NaN	-0.198000	0.086700	0.37600	NA	NA	NA	NA	NA
Toll Like Receptor 10 (TLR10) Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor 2 (TLR2) Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor 3 (TLR3) Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor 4 (TLR4) Cascade	14	NA	NA	0.2300	-0.23000	-0.003950	-0.000265	0.001980	-0.00616	NA	NA	NA	NA	NA
Toll Like Receptor 5 (TLR5) Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor 7/8 (TLR7/8) Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor 9 (TLR9) Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor TLR1:TLR2 Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll Like Receptor TLR6:TLR2 Cascade	12	NA	NA	0.2310	-0.23000	-0.003950	-0.004950	0.001980	-0.02060	NA	NA	NA	NA	NA
Toll-like Receptor Cascades	19	NA	NA	0.2480	-0.23500	0.028600	-0.042300	0.014100	0.05920	NA	NA	NA	NA	NA
Trafficking of AMPA receptors	6	NA	NA	0.5750	0.14200	NaN	0.123000	0.151000	0.52200	NA	NA	NA	NA	NA
Transcription of the HIV genome	9	NA	NA	0.2340	0.11500	0.015000	-0.184000	0.043500	-0.07540	NA	NA	NA	NA	NA
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	15	NA	NA	0.2420	0.14700	-0.040400	0.017200	-0.021800	-0.18600	NA	NA	NA	NA	NA
Transcriptional Regulation by E2F6	5	NA	NA	0.5390	0.40300	-0.092900	0.244000	NaN	-0.24500	NA	NA	NA	NA	NA
Transcriptional Regulation by MECP2	9	NA	NA	0.3450	-0.18600	-0.051200	0.087900	-0.206000	0.17800	NA	NA	NA	NA	NA
Transcriptional Regulation by TP53	53	NA	NA	0.2440	0.04770	-0.060900	0.097700	0.032500	-0.20700	NA	NA	NA	NA	NA
Transcriptional Regulation by VENTX	5	NA	NA	0.3800	0.17300	-0.075800	0.076400	NaN	-0.32100	NA	NA	NA	NA	NA
Transcriptional activation of mitochondrial biogenesis	8	NA	NA	0.2400	-0.02020	0.007250	0.077300	-0.206000	-0.09390	NA	NA	NA	NA	NA
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	9	NA	NA	0.3230	0.19000	0.022900	0.028100	-0.185000	-0.18100	NA	NA	NA	NA	NA
Transcriptional regulation by RUNX1	23	NA	NA	0.0815	-0.02660	0.063000	-0.014700	-0.039500	-0.01370	NA	NA	NA	NA	NA
Transcriptional regulation by RUNX2	19	NA	NA	0.2000	-0.13000	-0.097400	0.048700	-0.039500	0.09780	NA	NA	NA	NA	NA
Transcriptional regulation by RUNX3	17	NA	NA	0.1330	0.01580	0.076900	0.030200	-0.103000	-0.00469	NA	NA	NA	NA	NA
Transcriptional regulation by small RNAs	8	NA	NA	0.2950	0.14400	0.077500	0.059800	-0.023000	-0.23600	NA	NA	NA	NA	NA
Transcriptional regulation of white adipocyte differentiation	5	NA	NA	0.3600	-0.05640	NaN	0.277000	-0.199000	0.10200	NA	NA	NA	NA	NA
Translation	101	NA	NA	0.3500	0.12300	0.173000	-0.033700	-0.077800	-0.26500	NA	NA	NA	NA	NA
Translation initiation complex formation	26	NA	NA	0.3880	0.13300	0.159000	0.086600	-0.127000	-0.29000	NA	NA	NA	NA	NA
Translesion Synthesis by POLH	6	NA	NA	0.4640	0.28200	-0.079700	-0.005920	-0.207000	-0.29400	NA	NA	NA	NA	NA
Translesion synthesis by POLI	6	NA	NA	0.4640	0.28200	-0.079700	-0.005920	-0.207000	-0.29400	NA	NA	NA	NA	NA
Translesion synthesis by POLK	6	NA	NA	0.4640	0.28200	-0.079700	-0.005920	-0.207000	-0.29400	NA	NA	NA	NA	NA
Translesion synthesis by REV1	6	NA	NA	0.4640	0.28200	-0.079700	-0.005920	-0.207000	-0.29400	NA	NA	NA	NA	NA
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	9	NA	NA	0.5170	0.27900	-0.104000	-0.005920	-0.207000	-0.36800	NA	NA	NA	NA	NA
Translocation of SLC2A4 (GLUT4) to the plasma membrane	7	NA	NA	0.4840	-0.35900	NaN	0.075600	0.057900	0.31100	NA	NA	NA	NA	NA
Transmission across Chemical Synapses	19	NA	NA	0.3190	0.00162	0.019700	-0.081300	0.090700	0.29400	NA	NA	NA	NA	NA
Transport of Mature Transcript to Cytoplasm	15	NA	NA	0.3950	0.25200	-0.019700	0.083900	-0.122000	-0.26400	NA	NA	NA	NA	NA
Transport of Mature mRNA derived from an Intron-Containing Transcript	14	NA	NA	0.4110	0.24200	-0.024700	0.083900	-0.122000	-0.29500	NA	NA	NA	NA	NA
Transport of bile salts and organic acids, metal ions and amine compounds	5	NA	NA	0.1520	-0.14300	NaN	-0.011800	0.001320	0.05080	NA	NA	NA	NA	NA
Transport of inorganic cations/anions and amino acids/oligopeptides	12	NA	NA	0.2800	0.05980	NaN	-0.162000	0.156000	0.15500	NA	NA	NA	NA	NA
Transport to the Golgi and subsequent modification	13	NA	NA	0.2100	-0.13500	NaN	-0.049900	-0.005630	0.15200	NA	NA	NA	NA	NA
UCH proteinases	14	NA	NA	0.2420	0.17000	-0.001980	0.003080	-0.020500	-0.17100	NA	NA	NA	NA	NA
Ub-specific processing proteases	20	NA	NA	0.3470	0.25700	-0.064100	0.094700	-0.072600	-0.18900	NA	NA	NA	NA	NA
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
Ubiquitin-dependent degradation of Cyclin D	10	NA	NA	0.1260	-0.00262	-0.019700	0.017100	-0.039500	-0.11700	NA	NA	NA	NA	NA
Unwinding of DNA	7	NA	NA	0.5940	0.39300	-0.096800	0.095800	NaN	-0.42400	NA	NA	NA	NA	NA
Uptake and actions of bacterial toxins	8	NA	NA	0.1420	-0.06720	-0.063000	0.008920	-0.043500	0.09900	NA	NA	NA	NA	NA
VEGFA-VEGFR2 Pathway	10	NA	NA	0.3120	-0.16000	0.023100	-0.139000	NaN	0.22800	NA	NA	NA	NA	NA
VEGFR2 mediated vascular permeability	6	NA	NA	0.2430	-0.15800	0.023100	-0.092700	NaN	0.15800	NA	NA	NA	NA	NA
Vasopressin regulates renal water homeostasis via Aquaporins	5	NA	NA	0.4840	-0.26700	NaN	NaN	-0.025000	0.40300	NA	NA	NA	NA	NA
Vesicle-mediated transport	65	NA	NA	0.2570	-0.21300	0.001010	-0.029400	0.025600	0.13800	NA	NA	NA	NA	NA
Vif-mediated degradation of APOBEC3G	9	NA	NA	0.0722	-0.00262	-0.019700	0.043400	-0.039500	-0.03710	NA	NA	NA	NA	NA
Viral Messenger RNA Synthesis	7	NA	NA	0.2300	0.15400	0.077500	-0.048700	0.061700	-0.13000	NA	NA	NA	NA	NA
Viral mRNA Translation	49	NA	NA	0.4240	0.16200	0.184000	-0.131000	-0.144000	-0.28600	NA	NA	NA	NA	NA
Visual phototransduction	11	NA	NA	0.4620	-0.34800	0.099800	-0.079200	0.023000	0.27500	NA	NA	NA	NA	NA
Vpu mediated degradation of CD4	9	NA	NA	0.2850	-0.22800	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
mRNA 3'-end processing	12	NA	NA	0.4000	0.22600	-0.024700	0.082200	-0.122000	-0.29500	NA	NA	NA	NA	NA
mRNA Capping	5	NA	NA	0.2560	0.07050	0.077500	-0.184000	0.061700	-0.13000	NA	NA	NA	NA	NA
mRNA Splicing	55	NA	NA	0.4040	0.21300	-0.039200	0.098600	-0.002920	-0.32700	NA	NA	NA	NA	NA
mRNA Splicing - Major Pathway	54	NA	NA	0.4060	0.21700	-0.039200	0.098600	-0.002920	-0.32700	NA	NA	NA	NA	NA
mRNA Splicing - Minor Pathway	19	NA	NA	0.4990	0.24400	-0.037100	0.053500	0.061700	-0.42600	NA	NA	NA	NA	NA
mRNA decay by 5' to 3' exoribonuclease	6	NA	NA	0.5540	0.21400	-0.037800	0.145000	NaN	-0.48800	NA	NA	NA	NA	NA
p53-Dependent G1 DNA Damage Response	11	NA	NA	0.2930	0.13500	-0.086900	0.055500	-0.039500	-0.23500	NA	NA	NA	NA	NA
p53-Dependent G1/S DNA damage checkpoint	11	NA	NA	0.2930	0.13500	-0.086900	0.055500	-0.039500	-0.23500	NA	NA	NA	NA	NA
p53-Independent DNA Damage Response	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
p53-Independent G1/S DNA damage checkpoint	8	NA	NA	0.1710	-0.00262	-0.019700	0.043400	-0.039500	-0.15900	NA	NA	NA	NA	NA
p75 NTR receptor-mediated signalling	13	NA	NA	0.3230	-0.25700	-0.110000	-0.059500	-0.059300	0.13800	NA	NA	NA	NA	NA
p75NTR recruits signalling complexes	5	NA	NA	0.3890	-0.27000	NaN	-0.188000	-0.207000	0.01970	NA	NA	NA	NA	NA
p75NTR signals via NF-kB	5	NA	NA	0.3890	-0.27000	NaN	-0.188000	-0.207000	0.01970	NA	NA	NA	NA	NA
rRNA modification in the nucleus and cytosol	19	NA	NA	0.4160	0.21900	0.116000	0.094900	-0.112000	-0.30000	NA	NA	NA	NA	NA
snRNP Assembly	8	NA	NA	0.6830	0.38300	-0.089800	0.132000	NaN	-0.54200	NA	NA	NA	NA	NA
tRNA processing	5	NA	NA	0.5820	0.28100	0.047300	0.181000	-0.108000	-0.46100	NA	NA	NA	NA	NA
tRNA processing in the nucleus	5	NA	NA	0.5820	0.28100	0.047300	0.181000	-0.108000	-0.46100	NA	NA	NA	NA	NA
trans-Golgi Network Vesicle Budding	6	NA	NA	0.4310	-0.30400	0.167000	-0.223000	0.108000	-0.06290	NA	NA	NA	NA	NA

Detailed Gene set reports

B-WICH complex positively regulates rRNA expression

B-WICH complex positively regulates rRNA expression
metric	value
setSize	8
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.274
s.clus_0	0.111
s.clus_1	-0.0101
s.clus_2	0.0365
s.clus_3	-0.0309
s.clus_4	-0.246
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

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Top 20 genes
Gene	clus_4	clus_0
POLR2F	-615	302
DDX21	-437	187
POLR2H	-284	140
BAZ1B	-170	139
DEK	-419	50

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
POLR2F	302	-18	NA	NA	-615
DDX21	187	NA	NA	NA	-437
POLR1E	149	NA	NA	NA	NA
POLR2H	140	NA	NA	NA	-284
BAZ1B	139	-36	27	NA	-170
DEK	50	-200	190	-49	-419
POLR2L	-206	NA	-143	92	303
H2AFX	NA	NA	NA	NA	-230

Developmental Biology

Developmental Biology
metric	value
setSize	157
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.181
s.clus_0	-0.0591
s.clus_1	0.138
s.clus_2	-0.0638
s.clus_3	-0.0597
s.clus_4	0.0492
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

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Top 20 genes
Gene	clus_1	clus_2
RPL32	74	-201
ITGA10	48	-77
TSC22D1	45	-6

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
MYL6	-342	NA	-117	NA	439
RNPS1	368	NA	NA	-48	-217
MYC	367	-12	NA	-60	-492
TFDP1	353	NA	NA	NA	-254
RPS2	322	NA	NA	-96	-397
RPL12	316	NA	NA	NA	-273
POLR2F	302	-18	NA	NA	-615
RPS6	301	41	NA	-97	-19
RPSA	292	NA	NA	-69	-530
RPL9	272	NA	NA	NA	NA
HSP90AA1	270	-125	NA	NA	-351
RPL4	257	NA	NA	NA	-280
COL6A2	-312	NA	-133	NA	403
MAGOHB	219	-71	NA	NA	-475
RPL30	-307	NA	NA	NA	NA
SMARCA4	198	NA	NA	NA	-54
GSPT1	195	NA	NA	NA	-120
RPLP0	186	NA	NA	-75	-474
RBM8A	177	NA	NA	NA	-33
RPS21	-296	NA	177	NA	-6
COL6A1	-290	NA	-157	28	236
KRT10	-289	NA	NA	NA	NA
TSC22D1	-287	45	-6	NA	304
POLR2H	140	NA	NA	NA	-284
RPL22L1	126	NA	-34	NA	-16
ITGB1	-282	NA	-85	NA	420
PFN2	115	NA	NA	NA	NA
MAGOH	105	NA	NA	NA	-88
MYL12B	-257	NA	NA	NA	174
DEK	50	-200	190	-49	-419
HSPA8	45	NA	NA	NA	-126
CAPNS1	-250	NA	NA	NA	NA
ARPC3	-242	NA	NA	NA	NA
PSMA3	23	NA	NA	NA	-105
MMP9	-226	NA	-39	NA	419
RRAS	-221	NA	-60	NA	383
MBP	-214	NA	NA	127	NA
POLR2L	-206	NA	-143	92	303
SDCBP	-205	NA	NA	NA	275
MYL12A	-168	NA	-192	NA	393
GPC1	-156	NA	-21	42	NA
NRCAM	-155	NA	NA	NA	262
PSENEN	-149	NA	NA	NA	NA
CTNNA1	-131	NA	NA	NA	NA
CHL1	-129	NA	NA	18	NA
RHOC	-127	NA	-191	33	NA
KCNQ2	-119	NA	NA	NA	NA
ITGAV	-103	NA	NA	NA	336
ITGA1	-93	NA	-24	-3	457
MEF2C	-87	NA	-48	NA	351
GAP43	-80	NA	-108	36	101
SPTBN1	-69	NA	NA	NA	242
NRP2	-45	NA	NA	NA	6
FGFR1	-44	NA	NA	NA	134
JUN	-26	NA	NA	NA	47
ANK2	-21	NA	-41	198	-22
NCOR1	-18	NA	208	-112	NA
ITGA10	-16	48	-77	10	NA
RPS18	NA	78	NA	-118	NA
RPL6	NA	76	NA	NA	NA
RPL3	NA	75	NA	NA	NA
RPL32	NA	74	-201	NA	NA
RPS4X	NA	72	NA	NA	NA
RPL28	NA	70	NA	NA	NA
RPL18A	NA	68	NA	-117	NA
RPL10	NA	66	NA	NA	NA
RPS14	NA	65	NA	NA	NA
EZH2	NA	-133	NA	NA	-277
RPL10A	NA	63	NA	-56	NA
RPL27A	NA	61	NA	NA	NA
RPL15	NA	59	NA	NA	NA
RPS12	NA	58	NA	-87	-417
RPL13	NA	57	NA	NA	NA
RPL7A	NA	55	NA	NA	NA
PSMB2	NA	-92	NA	NA	NA
RPL39L	NA	-85	NA	NA	-223
RPS27	NA	49	NA	NA	NA
RPL23	NA	47	NA	NA	NA
RPL26	NA	44	NA	NA	NA
LEF1	NA	16	NA	NA	NA
PSMA7	NA	NA	206	NA	-189
HSP90AB1	NA	NA	182	-47	-489
RPL34	NA	NA	-217	NA	NA
COL9A3	NA	NA	81	NA	-11
RPL29	NA	NA	-194	NA	NA
RPS3A	NA	NA	-190	NA	NA
HDAC2	NA	NA	64	NA	-51
RPL41	NA	NA	-184	NA	NA
MPZ	NA	NA	47	1	-605
RPS20	NA	NA	31	NA	NA
CLTB	NA	NA	-173	NA	NA
PTPN11	NA	NA	11	NA	NA
UBC	NA	NA	-146	NA	NA
PDLIM7	NA	NA	-88	NA	42
UBA52	NA	NA	NA	-113	NA
RPS26	NA	NA	NA	186	NA
CACNG8	NA	NA	NA	182	339
CRMP1	NA	NA	NA	170	NA
RPL23A	NA	NA	NA	-105	-216
MMP2	NA	NA	NA	-103	NA
TGFB1	NA	NA	NA	-100	NA
SEMA5A	NA	NA	NA	155	NA
PSMB4	NA	NA	NA	143	NA
AP2S1	NA	NA	NA	138	NA
RPL14	NA	NA	NA	-89	-203
RPL21	NA	NA	NA	-84	-100
TRIO	NA	NA	NA	113	NA
SCD5	NA	NA	NA	110	NA
MYO10	NA	NA	NA	85	NA
RPS10	NA	NA	NA	-46	NA
SHTN1	NA	NA	NA	43	NA
EZR	NA	NA	NA	-18	NA
SOX10	NA	NA	NA	NA	-608
RPS19	NA	NA	NA	NA	-533
AP2M1	NA	NA	NA	NA	407
RPS16	NA	NA	NA	NA	-413
RPS27A	NA	NA	NA	NA	-410
RPS23	NA	NA	NA	NA	-379
RPL8	NA	NA	NA	NA	-361
RPLP2	NA	NA	NA	NA	-322
PABPC1	NA	NA	NA	NA	-318
RPLP1	NA	NA	NA	NA	-312
PFN1	NA	NA	NA	NA	-289
RPS25	NA	NA	NA	NA	-259
H2AFX	NA	NA	NA	NA	-230
RAC1	NA	NA	NA	NA	-213
TLN1	NA	NA	NA	NA	319
ARPC1A	NA	NA	NA	NA	-205
ETF1	NA	NA	NA	NA	-202
TCF4	NA	NA	NA	NA	312
FARP2	NA	NA	NA	NA	-146
POLR2I	NA	NA	NA	NA	-111
RBBP7	NA	NA	NA	NA	-101
PSMB3	NA	NA	NA	NA	-93
ELOB	NA	NA	NA	NA	266
ARPC1B	NA	NA	NA	NA	-72
SEMA6A	NA	NA	NA	NA	254
CDK4	NA	NA	NA	NA	-37
ENAH	NA	NA	NA	NA	232
FOXP1	NA	NA	NA	NA	230
FYN	NA	NA	NA	NA	190
ADAM10	NA	NA	NA	NA	170
PBX1	NA	NA	NA	NA	167
ACTG1	NA	NA	NA	NA	152
SHC1	NA	NA	NA	NA	147
DOK5	NA	NA	NA	NA	129
ROBO1	NA	NA	NA	NA	109
MEF2A	NA	NA	NA	NA	87
CTNNB1	NA	NA	NA	NA	82
IRS2	NA	NA	NA	NA	74
FURIN	NA	NA	NA	NA	64
CBFB	NA	NA	NA	NA	38
SOX2	NA	NA	NA	NA	35
DPYSL2	NA	NA	NA	NA	34
NR2F2	NA	NA	NA	NA	32
COL4A1	NA	NA	NA	NA	10
LPL	NA	NA	NA	NA	4

Epigenetic regulation of gene expression

Epigenetic regulation of gene expression
metric	value
setSize	14
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.282
s.clus_0	0.105
s.clus_1	-0.0327
s.clus_2	0.089
s.clus_3	-0.0309
s.clus_4	-0.242
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 37 rows containing non-finite values (stat_ydensity).

Warning: Removed 37 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_4	clus_0
POLR2F	-615	302
DDX21	-437	187
POLR2H	-284	140
BAZ1B	-170	139
DEK	-419	50
DNMT1	-219	72

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
POLR2F	302	-18	NA	NA	-615
DDX21	187	NA	NA	NA	-437
POLR1E	149	NA	NA	NA	NA
POLR2H	140	NA	NA	NA	-284
BAZ1B	139	-36	27	NA	-170
DNMT1	72	-121	NA	NA	-219
DEK	50	-200	190	-49	-419
POLR2L	-206	NA	-143	92	303
EZH2	NA	-133	NA	NA	-277
CBX3	NA	NA	183	NA	-331
HDAC2	NA	NA	64	NA	-51
PHF19	NA	NA	NA	NA	-554
H2AFX	NA	NA	NA	NA	-230
RBBP7	NA	NA	NA	NA	-101

Gene expression (Transcription)

Gene expression (Transcription)
metric	value
setSize	145
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.207
s.clus_0	0.0746
s.clus_1	-0.0303
s.clus_2	0.0951
s.clus_3	-0.0527
s.clus_4	-0.157
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 67 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 110 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 116 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 133 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 84 rows containing missing values

Warning: Removed 110 rows containing non-finite values (stat_density2d).

Warning: Removed 94 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 122 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 140 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 101 rows containing missing values

Warning: Removed 116 rows containing non-finite values (stat_density2d).

Warning: Removed 122 rows containing non-finite values (stat_density2d).

Warning: Removed 91 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 138 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 102 rows containing missing values

Warning: Removed 133 rows containing non-finite values (stat_density2d).

Warning: Removed 140 rows containing non-finite values (stat_density2d).

Warning: Removed 138 rows containing non-finite values (stat_density2d).

Warning: Removed 125 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 135 rows containing missing values

Warning: Removed 84 rows containing non-finite values (stat_density2d).

Warning: Removed 101 rows containing non-finite values (stat_density2d).

Warning: Removed 102 rows containing non-finite values (stat_density2d).

Warning: Removed 135 rows containing non-finite values (stat_density2d).

Warning: Removed 32 rows containing non-finite values (stat_bin).

Warning: Removed 67 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 110 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 116 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 133 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 84 rows containing missing values

Warning: Removed 110 rows containing missing values (geom_point).

Warning: Removed 94 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 122 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 140 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 101 rows containing missing values

Warning: Removed 116 rows containing missing values (geom_point).

Warning: Removed 122 rows containing missing values (geom_point).

Warning: Removed 91 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 138 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 102 rows containing missing values

Warning: Removed 133 rows containing missing values (geom_point).

Warning: Removed 140 rows containing missing values (geom_point).

Warning: Removed 138 rows containing missing values (geom_point).

Warning: Removed 125 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 135 rows containing missing values

Warning: Removed 84 rows containing missing values (geom_point).

Warning: Removed 101 rows containing missing values (geom_point).

Warning: Removed 102 rows containing missing values (geom_point).

Warning: Removed 135 rows containing missing values (geom_point).

Warning: Removed 32 rows containing non-finite values (stat_bin).

Warning in grid.Call.graphics(C_points, x$x, x$y, x$pch, x$size): semi-
transparency is not supported on this device: reported only once per page

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 409 rows containing non-finite values (stat_ydensity).

Warning: Removed 409 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_4	clus_2
RAN	-609	207
HSPD1	-610	189
UBE2S	-584	194
TPX2	-537	210
NPM1	-611	169
BIRC5	-569	179
SNRPF	-548	180
CCNB1	-454	200
PRMT1	-547	165
CYCS	-607	137
DEK	-419	190
PLD6	-345	201
CBX3	-331	183
GTF3A	-523	114
SRSF3	-549	98
FANCI	-561	80
PRELID1	-606	74
SNRPE	-576	69
PSMA7	-189	206
SNRPD3	-497	77

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
SNRPB	381	-166	NA	NA	-495
RNPS1	368	NA	NA	-48	-217
MYC	367	-12	NA	-60	-492
NDUFA4	-340	NA	NA	153	NA
SRSF2	359	-57	NA	NA	-565
COX6C	-337	NA	NA	175	NA
TFDP1	353	NA	NA	NA	-254
PARP1	335	-190	34	NA	-433
NUP210	332	NA	NA	NA	NA
BID	323	NA	NA	-70	-317
RRM2	311	-162	NA	NA	-358
CCNA2	304	-194	5	NA	-392
POLR2F	302	-18	NA	NA	-615
HSPD1	298	-77	189	NA	-610
SLBP	291	-69	NA	NA	-42
SRSF7	290	-79	21	NA	-585
POLR3K	287	-72	NA	NA	-416
RFC4	278	-111	NA	NA	-211
BIRC5	277	-228	179	NA	-569
HSP90AA1	270	-125	NA	NA	-351
SKP1	-321	NA	NA	NA	NA
SSRP1	251	NA	NA	NA	-385
COX5A	250	NA	NA	NA	-570
POLR3G	224	NA	NA	NA	-476
MAGOHB	219	-71	NA	NA	-475
SNRPD3	213	NA	77	NA	-497
CDK1	208	-150	NA	NA	-195
PCNA	202	-157	NA	NA	-303
SMARCA4	198	NA	NA	NA	-54
TFAM	188	NA	NA	NA	-229
DDX21	187	NA	NA	NA	-437
RBM8A	177	NA	NA	NA	-33
APOE	-302	NA	-59	NA	448
YWHAZ	-299	NA	NA	147	NA
UBE2S	157	-223	194	NA	-584
SRSF3	151	-100	98	NA	-549
POLR1E	149	NA	NA	NA	NA
UBE2I	141	NA	NA	NA	-45
POLR2H	140	NA	NA	NA	-284
BAZ1B	139	-36	27	NA	-170
SRSF11	137	NA	NA	NA	NA
CYCS	129	-23	137	NA	-607
ALYREF	113	-134	NA	NA	-163
NR2F6	112	NA	NA	-77	NA
MAGOH	105	NA	NA	NA	-88
RAN	104	NA	207	-37	-609
NOC2L	94	NA	NA	NA	NA
CAV1	-274	6	-72	NA	396
SUPT16H	74	-101	NA	NA	-127
DNMT1	72	-121	NA	NA	-219
PRDX2	67	-39	NA	NA	NA
PCBP4	56	NA	NA	NA	-350
DEK	50	-200	190	-49	-419
SMARCC1	35	NA	NA	NA	-226
TRIM28	34	NA	28	NA	-194
PRMT1	33	NA	165	NA	-547
DDX39A	31	-132	NA	NA	NA
CALM1	-244	NA	-75	NA	297
PSMA3	23	NA	NA	NA	-105
YWHAB	-241	NA	184	NA	NA
IGFBP3	-228	73	-4	NA	0
SSU72	9	NA	NA	NA	NA
NPM1	5	NA	169	NA	-611
POLR2L	-206	NA	-143	92	303
ZKSCAN1	-197	40	NA	NA	NA
CDKN2B	-190	23	-23	NA	131
BTG1	-162	62	NA	-20	NA
SPP1	-151	NA	-22	NA	421
LGALS3	-150	NA	-61	NA	299
MAF	-128	NA	NA	NA	290
CCND2	-110	-31	-149	NA	51
TMEM219	-105	NA	-107	NA	NA
CTGF	-91	12	NA	NA	14
MEF2C	-87	NA	-48	NA	351
NR2F1	-54	NA	NA	NA	294
JUN	-26	NA	NA	NA	47
NCOR1	-18	NA	208	-112	NA
CITED1	-14	1	-2	NA	-104
TPX2	NA	-224	210	-6	-537
CCNB1	NA	-210	200	NA	-454
UBE2C	NA	-196	1	NA	-465
MYBL2	NA	-180	NA	NA	-482
FANCI	NA	-178	80	NA	-561
ATAD2	NA	-176	NA	NA	-324
RPA3	NA	-144	131	NA	-283
SNRPG	NA	-143	NA	NA	-225
EZH2	NA	-133	NA	NA	-277
SNRPE	NA	-118	69	NA	-576
LBR	NA	-116	168	NA	-207
AURKA	NA	-115	104	NA	-196
PSMB2	NA	-92	NA	NA	NA
GTF2A2	NA	-78	NA	64	-86
NFATC2	NA	35	NA	NA	NA
LEF1	NA	16	NA	NA	NA
PSMA7	NA	NA	206	NA	-189
PLD6	NA	NA	201	-57	-345
CBX3	NA	NA	183	NA	-331
SNRPF	NA	NA	180	NA	-548
GTF3A	NA	NA	114	-58	-523
SSB	NA	NA	101	NA	-252
MDM2	NA	NA	91	NA	NA
PRELID1	NA	NA	74	NA	-606
HDAC2	NA	NA	64	NA	-51
RAE1	NA	NA	63	NA	NA
DYRK2	NA	NA	26	NA	NA
PTPN11	NA	NA	11	NA	NA
CDK6	NA	NA	8	NA	NA
UBC	NA	NA	-146	NA	NA
RSPO3	NA	NA	-130	NA	NA
GADD45A	NA	NA	-56	NA	156
CCND1	NA	NA	-30	NA	NA
UBA52	NA	NA	NA	-113	NA
COX7C	NA	NA	NA	176	NA
TGFB1	NA	NA	NA	-100	NA
PSMB4	NA	NA	NA	143	NA
PHF19	NA	NA	NA	NA	-554
PRDX1	NA	NA	NA	NA	-511
SOCS3	NA	NA	NA	NA	406
TXN	NA	NA	NA	NA	-503
RPS27A	NA	NA	NA	NA	-410
HIPK2	NA	NA	NA	NA	-279
HEY1	NA	NA	NA	NA	335
H2AFX	NA	NA	NA	NA	-230
SRSF9	NA	NA	NA	NA	-180
GTF2F2	NA	NA	NA	NA	-177
THOC7	NA	NA	NA	NA	-160
BNIP3L	NA	NA	NA	NA	277
POLR2I	NA	NA	NA	NA	-111
RBBP7	NA	NA	NA	NA	-101
PSMB3	NA	NA	NA	NA	-93
SMAD1	NA	NA	NA	NA	268
ELOB	NA	NA	NA	NA	266
CDK4	NA	NA	NA	NA	-37
BBC3	NA	NA	NA	NA	237
CAMK2D	NA	NA	NA	NA	212
NR3C1	NA	NA	NA	NA	199
SESN3	NA	NA	NA	NA	182
JUNB	NA	NA	NA	NA	165
CTSL	NA	NA	NA	NA	102
SGK1	NA	NA	NA	NA	100
CTNNB1	NA	NA	NA	NA	82
PPP2CB	NA	NA	NA	NA	70
FOS	NA	NA	NA	NA	45
CBFB	NA	NA	NA	NA	38
SOX2	NA	NA	NA	NA	35

Generic Transcription Pathway

Generic Transcription Pathway
metric	value
setSize	110
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.114
s.clus_0	-0.0057
s.clus_1	-0.0263
s.clus_2	0.0758
s.clus_3	-0.0362
s.clus_4	-0.0728
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 56 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 87 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 86 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 100 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 68 rows containing missing values

Warning: Removed 87 rows containing non-finite values (stat_density2d).

Warning: Removed 74 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 91 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 80 rows containing missing values

Warning: Removed 86 rows containing non-finite values (stat_density2d).

Warning: Removed 91 rows containing non-finite values (stat_density2d).

Warning: Removed 67 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values

Warning: Removed 100 rows containing non-finite values (stat_density2d).

Warning: Removed 106 rows containing non-finite values (stat_density2d).

Warning: Removed 106 rows containing non-finite values (stat_density2d).

Warning: Removed 95 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 105 rows containing missing values

Warning: Removed 68 rows containing non-finite values (stat_density2d).

Warning: Removed 80 rows containing non-finite values (stat_density2d).

Warning: Removed 77 rows containing non-finite values (stat_density2d).

Warning: Removed 105 rows containing non-finite values (stat_density2d).

Warning: Removed 26 rows containing non-finite values (stat_bin).

Warning: Removed 56 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 87 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 86 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 100 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 68 rows containing missing values

Warning: Removed 87 rows containing missing values (geom_point).

Warning: Removed 74 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 91 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 80 rows containing missing values

Warning: Removed 86 rows containing missing values (geom_point).

Warning: Removed 91 rows containing missing values (geom_point).

Warning: Removed 67 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 106 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values

Warning: Removed 100 rows containing missing values (geom_point).

Warning: Removed 106 rows containing missing values (geom_point).

Warning: Removed 106 rows containing missing values (geom_point).

Warning: Removed 95 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 105 rows containing missing values

Warning: Removed 68 rows containing missing values (geom_point).

Warning: Removed 80 rows containing missing values (geom_point).

Warning: Removed 77 rows containing missing values (geom_point).

Warning: Removed 105 rows containing missing values (geom_point).

Warning: Removed 26 rows containing non-finite values (stat_bin).

Warning in grid.Call.graphics(C_points, x$x, x$y, x$pch, x$size): semi-
transparency is not supported on this device: reported only once per page

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 318 rows containing non-finite values (stat_ydensity).

Warning: Removed 318 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_2	clus_4
HSPD1	189	-610
UBE2S	194	-584
TPX2	210	-537
NPM1	169	-611
BIRC5	179	-569
CCNB1	200	-454
PRMT1	165	-547
CYCS	137	-607
DEK	190	-419
CBX3	183	-331
FANCI	80	-561
PRELID1	74	-606
PSMA7	206	-189
RPA3	131	-283
LBR	168	-207
AURKA	104	-196
PARP1	34	-433
TRIM28	28	-194
HDAC2	64	-51
CCNA2	5	-392

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
MYC	367	-12	NA	-60	-492
NDUFA4	-340	NA	NA	153	NA
COX6C	-337	NA	NA	175	NA
TFDP1	353	NA	NA	NA	-254
PARP1	335	-190	34	NA	-433
BID	323	NA	NA	-70	-317
RRM2	311	-162	NA	NA	-358
CCNA2	304	-194	5	NA	-392
POLR2F	302	-18	NA	NA	-615
HSPD1	298	-77	189	NA	-610
RFC4	278	-111	NA	NA	-211
BIRC5	277	-228	179	NA	-569
SKP1	-321	NA	NA	NA	NA
SSRP1	251	NA	NA	NA	-385
COX5A	250	NA	NA	NA	-570
CDK1	208	-150	NA	NA	-195
PCNA	202	-157	NA	NA	-303
SMARCA4	198	NA	NA	NA	-54
APOE	-302	NA	-59	NA	448
YWHAZ	-299	NA	NA	147	NA
UBE2S	157	-223	194	NA	-584
UBE2I	141	NA	NA	NA	-45
POLR2H	140	NA	NA	NA	-284
CYCS	129	-23	137	NA	-607
NR2F6	112	NA	NA	-77	NA
NOC2L	94	NA	NA	NA	NA
CAV1	-274	6	-72	NA	396
SUPT16H	74	-101	NA	NA	-127
PRDX2	67	-39	NA	NA	NA
PCBP4	56	NA	NA	NA	-350
DEK	50	-200	190	-49	-419
SMARCC1	35	NA	NA	NA	-226
TRIM28	34	NA	28	NA	-194
PRMT1	33	NA	165	NA	-547
CALM1	-244	NA	-75	NA	297
PSMA3	23	NA	NA	NA	-105
YWHAB	-241	NA	184	NA	NA
IGFBP3	-228	73	-4	NA	0
NPM1	5	NA	169	NA	-611
POLR2L	-206	NA	-143	92	303
ZKSCAN1	-197	40	NA	NA	NA
CDKN2B	-190	23	-23	NA	131
BTG1	-162	62	NA	-20	NA
SPP1	-151	NA	-22	NA	421
LGALS3	-150	NA	-61	NA	299
MAF	-128	NA	NA	NA	290
CCND2	-110	-31	-149	NA	51
TMEM219	-105	NA	-107	NA	NA
CTGF	-91	12	NA	NA	14
MEF2C	-87	NA	-48	NA	351
NR2F1	-54	NA	NA	NA	294
JUN	-26	NA	NA	NA	47
NCOR1	-18	NA	208	-112	NA
CITED1	-14	1	-2	NA	-104
TPX2	NA	-224	210	-6	-537
CCNB1	NA	-210	200	NA	-454
UBE2C	NA	-196	1	NA	-465
MYBL2	NA	-180	NA	NA	-482
FANCI	NA	-178	80	NA	-561
ATAD2	NA	-176	NA	NA	-324
RPA3	NA	-144	131	NA	-283
EZH2	NA	-133	NA	NA	-277
LBR	NA	-116	168	NA	-207
AURKA	NA	-115	104	NA	-196
PSMB2	NA	-92	NA	NA	NA
NFATC2	NA	35	NA	NA	NA
LEF1	NA	16	NA	NA	NA
PSMA7	NA	NA	206	NA	-189
CBX3	NA	NA	183	NA	-331
MDM2	NA	NA	91	NA	NA
PRELID1	NA	NA	74	NA	-606
HDAC2	NA	NA	64	NA	-51
DYRK2	NA	NA	26	NA	NA
PTPN11	NA	NA	11	NA	NA
CDK6	NA	NA	8	NA	NA
UBC	NA	NA	-146	NA	NA
RSPO3	NA	NA	-130	NA	NA
GADD45A	NA	NA	-56	NA	156
CCND1	NA	NA	-30	NA	NA
UBA52	NA	NA	NA	-113	NA
COX7C	NA	NA	NA	176	NA
TGFB1	NA	NA	NA	-100	NA
PSMB4	NA	NA	NA	143	NA
PRDX1	NA	NA	NA	NA	-511
SOCS3	NA	NA	NA	NA	406
TXN	NA	NA	NA	NA	-503
RPS27A	NA	NA	NA	NA	-410
HIPK2	NA	NA	NA	NA	-279
HEY1	NA	NA	NA	NA	335
H2AFX	NA	NA	NA	NA	-230
GTF2F2	NA	NA	NA	NA	-177
BNIP3L	NA	NA	NA	NA	277
POLR2I	NA	NA	NA	NA	-111
RBBP7	NA	NA	NA	NA	-101
PSMB3	NA	NA	NA	NA	-93
SMAD1	NA	NA	NA	NA	268
ELOB	NA	NA	NA	NA	266
CDK4	NA	NA	NA	NA	-37
BBC3	NA	NA	NA	NA	237
CAMK2D	NA	NA	NA	NA	212
NR3C1	NA	NA	NA	NA	199
SESN3	NA	NA	NA	NA	182
JUNB	NA	NA	NA	NA	165
CTSL	NA	NA	NA	NA	102
SGK1	NA	NA	NA	NA	100
CTNNB1	NA	NA	NA	NA	82
PPP2CB	NA	NA	NA	NA	70
FOS	NA	NA	NA	NA	45
CBFB	NA	NA	NA	NA	38
SOX2	NA	NA	NA	NA	35

Positive epigenetic regulation of rRNA expression

Positive epigenetic regulation of rRNA expression
metric	value
setSize	11
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.252
s.clus_0	0.111
s.clus_1	-0.0101
s.clus_2	0.089
s.clus_3	-0.0309
s.clus_4	-0.205
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 28 rows containing non-finite values (stat_ydensity).

Warning: Removed 28 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_4	clus_0
POLR2F	-615	302
DDX21	-437	187
POLR2H	-284	140
BAZ1B	-170	139
DEK	-419	50

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
POLR2F	302	-18	NA	NA	-615
DDX21	187	NA	NA	NA	-437
POLR1E	149	NA	NA	NA	NA
POLR2H	140	NA	NA	NA	-284
BAZ1B	139	-36	27	NA	-170
DEK	50	-200	190	-49	-419
POLR2L	-206	NA	-143	92	303
CBX3	NA	NA	183	NA	-331
HDAC2	NA	NA	64	NA	-51
H2AFX	NA	NA	NA	NA	-230
RBBP7	NA	NA	NA	NA	-101

RNA Polymerase II Transcription

RNA Polymerase II Transcription
metric	value
setSize	130
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.162
s.clus_0	0.0482
s.clus_1	-0.0308
s.clus_2	0.0829
s.clus_3	-0.0381
s.clus_4	-0.121
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 62 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 99 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 103 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 119 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values

Warning: Removed 99 rows containing non-finite values (stat_density2d).

Warning: Removed 83 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 108 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 125 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 90 rows containing missing values

Warning: Removed 103 rows containing non-finite values (stat_density2d).

Warning: Removed 108 rows containing non-finite values (stat_density2d).

Warning: Removed 82 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 126 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 92 rows containing missing values

Warning: Removed 119 rows containing non-finite values (stat_density2d).

Warning: Removed 125 rows containing non-finite values (stat_density2d).

Warning: Removed 126 rows containing non-finite values (stat_density2d).

Warning: Removed 113 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 123 rows containing missing values

Warning: Removed 77 rows containing non-finite values (stat_density2d).

Warning: Removed 90 rows containing non-finite values (stat_density2d).

Warning: Removed 92 rows containing non-finite values (stat_density2d).

Warning: Removed 123 rows containing non-finite values (stat_density2d).

Warning: Removed 29 rows containing non-finite values (stat_bin).

Warning: Removed 62 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 99 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 103 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 119 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 77 rows containing missing values

Warning: Removed 99 rows containing missing values (geom_point).

Warning: Removed 83 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 108 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 125 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 90 rows containing missing values

Warning: Removed 103 rows containing missing values (geom_point).

Warning: Removed 108 rows containing missing values (geom_point).

Warning: Removed 82 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 126 rows containing missing values

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 92 rows containing missing values

Warning: Removed 119 rows containing missing values (geom_point).

Warning: Removed 125 rows containing missing values (geom_point).

Warning: Removed 126 rows containing missing values (geom_point).

Warning: Removed 113 rows containing non-finite values (stat_bin).

Warning in ggally_statistic(data = data, mapping = mapping, na.rm = na.rm, :
Removed 123 rows containing missing values

Warning: Removed 77 rows containing missing values (geom_point).

Warning: Removed 90 rows containing missing values (geom_point).

Warning: Removed 92 rows containing missing values (geom_point).

Warning: Removed 123 rows containing missing values (geom_point).

Warning: Removed 29 rows containing non-finite values (stat_bin).

Warning in grid.Call.graphics(C_points, x$x, x$y, x$pch, x$size): semi-
transparency is not supported on this device: reported only once per page

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 369 rows containing non-finite values (stat_ydensity).

Warning: Removed 369 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_4	clus_2
HSPD1	-610	189
UBE2S	-584	194
TPX2	-537	210
NPM1	-611	169
BIRC5	-569	179
SNRPF	-548	180
CCNB1	-454	200
PRMT1	-547	165
CYCS	-607	137
DEK	-419	190
CBX3	-331	183
SRSF3	-549	98
FANCI	-561	80
PRELID1	-606	74
SNRPE	-576	69
PSMA7	-189	206
SNRPD3	-497	77
RPA3	-283	131
LBR	-207	168
AURKA	-196	104

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
SNRPB	381	-166	NA	NA	-495
RNPS1	368	NA	NA	-48	-217
MYC	367	-12	NA	-60	-492
NDUFA4	-340	NA	NA	153	NA
SRSF2	359	-57	NA	NA	-565
COX6C	-337	NA	NA	175	NA
TFDP1	353	NA	NA	NA	-254
PARP1	335	-190	34	NA	-433
BID	323	NA	NA	-70	-317
RRM2	311	-162	NA	NA	-358
CCNA2	304	-194	5	NA	-392
POLR2F	302	-18	NA	NA	-615
HSPD1	298	-77	189	NA	-610
SLBP	291	-69	NA	NA	-42
SRSF7	290	-79	21	NA	-585
RFC4	278	-111	NA	NA	-211
BIRC5	277	-228	179	NA	-569
SKP1	-321	NA	NA	NA	NA
SSRP1	251	NA	NA	NA	-385
COX5A	250	NA	NA	NA	-570
MAGOHB	219	-71	NA	NA	-475
SNRPD3	213	NA	77	NA	-497
CDK1	208	-150	NA	NA	-195
PCNA	202	-157	NA	NA	-303
SMARCA4	198	NA	NA	NA	-54
RBM8A	177	NA	NA	NA	-33
APOE	-302	NA	-59	NA	448
YWHAZ	-299	NA	NA	147	NA
UBE2S	157	-223	194	NA	-584
SRSF3	151	-100	98	NA	-549
UBE2I	141	NA	NA	NA	-45
POLR2H	140	NA	NA	NA	-284
SRSF11	137	NA	NA	NA	NA
CYCS	129	-23	137	NA	-607
ALYREF	113	-134	NA	NA	-163
NR2F6	112	NA	NA	-77	NA
MAGOH	105	NA	NA	NA	-88
NOC2L	94	NA	NA	NA	NA
CAV1	-274	6	-72	NA	396
SUPT16H	74	-101	NA	NA	-127
PRDX2	67	-39	NA	NA	NA
PCBP4	56	NA	NA	NA	-350
DEK	50	-200	190	-49	-419
SMARCC1	35	NA	NA	NA	-226
TRIM28	34	NA	28	NA	-194
PRMT1	33	NA	165	NA	-547
DDX39A	31	-132	NA	NA	NA
CALM1	-244	NA	-75	NA	297
PSMA3	23	NA	NA	NA	-105
YWHAB	-241	NA	184	NA	NA
IGFBP3	-228	73	-4	NA	0
SSU72	9	NA	NA	NA	NA
NPM1	5	NA	169	NA	-611
POLR2L	-206	NA	-143	92	303
ZKSCAN1	-197	40	NA	NA	NA
CDKN2B	-190	23	-23	NA	131
BTG1	-162	62	NA	-20	NA
SPP1	-151	NA	-22	NA	421
LGALS3	-150	NA	-61	NA	299
MAF	-128	NA	NA	NA	290
CCND2	-110	-31	-149	NA	51
TMEM219	-105	NA	-107	NA	NA
CTGF	-91	12	NA	NA	14
MEF2C	-87	NA	-48	NA	351
NR2F1	-54	NA	NA	NA	294
JUN	-26	NA	NA	NA	47
NCOR1	-18	NA	208	-112	NA
CITED1	-14	1	-2	NA	-104
TPX2	NA	-224	210	-6	-537
CCNB1	NA	-210	200	NA	-454
UBE2C	NA	-196	1	NA	-465
MYBL2	NA	-180	NA	NA	-482
FANCI	NA	-178	80	NA	-561
ATAD2	NA	-176	NA	NA	-324
RPA3	NA	-144	131	NA	-283
SNRPG	NA	-143	NA	NA	-225
EZH2	NA	-133	NA	NA	-277
SNRPE	NA	-118	69	NA	-576
LBR	NA	-116	168	NA	-207
AURKA	NA	-115	104	NA	-196
PSMB2	NA	-92	NA	NA	NA
GTF2A2	NA	-78	NA	64	-86
NFATC2	NA	35	NA	NA	NA
LEF1	NA	16	NA	NA	NA
PSMA7	NA	NA	206	NA	-189
CBX3	NA	NA	183	NA	-331
SNRPF	NA	NA	180	NA	-548
MDM2	NA	NA	91	NA	NA
PRELID1	NA	NA	74	NA	-606
HDAC2	NA	NA	64	NA	-51
DYRK2	NA	NA	26	NA	NA
PTPN11	NA	NA	11	NA	NA
CDK6	NA	NA	8	NA	NA
UBC	NA	NA	-146	NA	NA
RSPO3	NA	NA	-130	NA	NA
GADD45A	NA	NA	-56	NA	156
CCND1	NA	NA	-30	NA	NA
UBA52	NA	NA	NA	-113	NA
COX7C	NA	NA	NA	176	NA
TGFB1	NA	NA	NA	-100	NA
PSMB4	NA	NA	NA	143	NA
PRDX1	NA	NA	NA	NA	-511
SOCS3	NA	NA	NA	NA	406
TXN	NA	NA	NA	NA	-503
RPS27A	NA	NA	NA	NA	-410
HIPK2	NA	NA	NA	NA	-279
HEY1	NA	NA	NA	NA	335
H2AFX	NA	NA	NA	NA	-230
SRSF9	NA	NA	NA	NA	-180
GTF2F2	NA	NA	NA	NA	-177
THOC7	NA	NA	NA	NA	-160
BNIP3L	NA	NA	NA	NA	277
POLR2I	NA	NA	NA	NA	-111
RBBP7	NA	NA	NA	NA	-101
PSMB3	NA	NA	NA	NA	-93
SMAD1	NA	NA	NA	NA	268
ELOB	NA	NA	NA	NA	266
CDK4	NA	NA	NA	NA	-37
BBC3	NA	NA	NA	NA	237
CAMK2D	NA	NA	NA	NA	212
NR3C1	NA	NA	NA	NA	199
SESN3	NA	NA	NA	NA	182
JUNB	NA	NA	NA	NA	165
CTSL	NA	NA	NA	NA	102
SGK1	NA	NA	NA	NA	100
CTNNB1	NA	NA	NA	NA	82
PPP2CB	NA	NA	NA	NA	70
FOS	NA	NA	NA	NA	45
CBFB	NA	NA	NA	NA	38
SOX2	NA	NA	NA	NA	35

Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
metric	value
setSize	9
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.349
s.clus_0	0.0698
s.clus_1	-0.0405
s.clus_2	0.133
s.clus_3	-0.131
s.clus_4	-0.284
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 16 rows containing non-finite values (stat_ydensity).

Warning: Removed 16 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_4	clus_2
HSPD1	-610	189
NPM1	-611	169
DEK	-419	190

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
MYC	367	-12	NA	-60	-492
HSPD1	298	-77	189	NA	-610
APOE	-302	NA	-59	NA	448
UBE2I	141	NA	NA	NA	-45
DEK	50	-200	190	-49	-419
NPM1	5	NA	169	NA	-611
CITED1	-14	1	-2	NA	-104
MYBL2	NA	-180	NA	NA	-482
ATAD2	NA	-176	NA	NA	-324

Transcriptional regulation of granulopoiesis

Transcriptional regulation of granulopoiesis
metric	value
setSize	7
pMANOVA	5.07e-06
p.adjustMANOVA	2.59e-05
s.dist	0.464
s.clus_0	0.304
s.clus_1	0.0154
s.clus_2	0.253
s.clus_3	-0.131
s.clus_4	-0.203
p.clus_0	0.913
p.clus_1	0.000207
p.clus_2	0.044
p.clus_3	0.358
p.clus_4	0.4

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 20 rows containing non-finite values (stat_ydensity).

Warning: Removed 20 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_0	clus_2
DEK	50	190

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
MYC	367	-12	NA	-60	-492
TFDP1	353	NA	NA	NA	-254
DEK	50	-200	190	-49	-419
LEF1	NA	16	NA	NA	NA
H2AFX	NA	NA	NA	NA	-230
CDK4	NA	NA	NA	NA	-37
CBFB	NA	NA	NA	NA	38

IRE1alpha activates chaperones

IRE1alpha activates chaperones
metric	value
setSize	9
pMANOVA	0.0807
p.adjustMANOVA	0.309
s.dist	0.229
s.clus_0	0.073
s.clus_1	0.0441
s.clus_2	0.101
s.clus_3	-0.097
s.clus_4	0.16
p.clus_0	0.222
p.clus_1	0.205
p.clus_2	0.415
p.clus_3	0.249
p.clus_4	0.863

Warning: Removed 4751 rows containing non-finite values (stat_ydensity).

Warning: Removed 4751 rows containing non-finite values (stat_boxplot).

Warning: Removed 27 rows containing non-finite values (stat_ydensity).

Warning: Removed 27 rows containing non-finite values (stat_boxplot).

Top 20 genes
Gene	clus_4	clus_2

Click HERE to show all gene set members

All member genes
	clus_0	clus_1	clus_2	clus_3	clus_4
HDGF	297	-95	73	-65	-13
KDELR3	175	NA	NA	-99	-457
LMNA	-77	8	NA	-16	NA
ACADVL	-73	NA	NA	NA	183
SSR1	NA	NA	75	NA	NA
DNAJC3	NA	NA	NA	67	NA
TLN1	NA	NA	NA	NA	319
SHC1	NA	NA	NA	NA	147
ADD1	NA	NA	NA	NA	84

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.0.0 (2020-04-24)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 18.04.5 LTS
## 
## Matrix products: default
## BLAS:   /mnt/md0/app/R-4.0.0/lib/libRblas.so
## LAPACK: /mnt/md0/app/R-4.0.0/lib/libRlapack.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  grid      stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] mitch_1.1.8     plyr_1.8.6      pbmcapply_1.5.0 knitr_1.30     
##  [5] rmarkdown_2.4   pkgload_1.1.0   beeswarm_0.2.3  gtools_3.8.2   
##  [9] tibble_3.0.3    dplyr_1.0.2     echarts4r_0.3.2 magrittr_1.5   
## [13] reshape2_1.4.4  MASS_7.3-53     gplots_3.1.0    gridExtra_2.3  
## [17] GGally_2.0.0    ggplot2_3.3.2  
## 
## loaded via a namespace (and not attached):
##  [1] Rcpp_1.0.5         prettyunits_1.1.1  assertthat_0.2.1   rprojroot_1.3-2   
##  [5] digest_0.6.25      mime_0.9           R6_2.4.1           backports_1.1.10  
##  [9] evaluate_0.14      highr_0.8          pillar_1.4.6       rlang_0.4.7       
## [13] progress_1.2.2     desc_1.2.0         labeling_0.3       stringr_1.4.0     
## [17] htmlwidgets_1.5.2  munsell_0.5.0      shiny_1.5.0        compiler_4.0.0    
## [21] httpuv_1.5.4       xfun_0.18          pkgconfig_2.0.3    htmltools_0.5.0   
## [25] tidyselect_1.1.0   reshape_0.8.8      crayon_1.3.4       withr_2.3.0       
## [29] later_1.1.0.1      bitops_1.0-6       jsonlite_1.7.1     xtable_1.8-4      
## [33] gtable_0.3.0       lifecycle_0.2.0    scales_1.1.1       KernSmooth_2.23-17
## [37] stringi_1.5.3      farver_2.0.3       promises_1.1.1     testthat_2.3.2    
## [41] ellipsis_0.3.1     generics_0.0.2     vctrs_0.3.4        RColorBrewer_1.1-2
## [45] tools_4.0.0        glue_1.4.2         purrr_0.3.4        hms_0.5.3         
## [49] fastmap_1.0.1      yaml_2.2.1         colorspace_1.4-1   caTools_1.18.0

END of report

	clus_0	clus_1	clus_2	clus_3	clus_4	Count
1	1	-1	-1	-1	-1	1
2	1	-1	1	-1	-1	5
3	-1	1	-1	1	-1	3
4	-1	-1	-1	-1	1	3
5	-1	0	0	-1	1	1
6	-1	-1	-1	0	1	1
7	-1	1	-1	1	1	1

	clus_0	clus_1	clus_2	clus_3	clus_4	Count
1	1	-1	-1	-1	-1	1
2	1	-1	1	-1	-1	5
3	-1	1	-1	1	-1	3
4	-1	-1	-1	-1	1	3
5	-1	0	0	-1	1	1
6	-1	-1	-1	0	1	1
7	-1	1	-1	1	1	1

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Gene sets by sector

Interactive enrichment scatterplot

A heatmap of S values for top results

A plot of effect size versus significance

Results table

Results (complete table)

Detailed Gene set reports

	clus_0	clus_1	clus_2	clus_3	clus_4	Count
1	1	-1	-1	-1	-1	1
2	1	-1	1	-1	-1	5
3	-1	1	-1	1	-1	3
4	-1	-1	-1	-1	1	3
5	-1	0	0	-1	1	1
6	-1	-1	-1	0	1	1
7	-1	1	-1	1	1	1