date generated: 2024-06-05

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik -0.3304181 0.0972207
0610009E02Rik 0.7596333 1.2632625
0610009L18Rik -1.2521412 -0.6637497
0610010K14Rik 0.4193627 -0.4536898
0610012G03Rik 1.4462155 0.1223624
0610030E20Rik -0.2426628 -0.0456229

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 16956
duplicated_genes_present 0
num_profile_genes_in_sets 8348
num_profile_genes_not_in_sets 8608
profile_pearson_correl 0.42429
profile_spearman_correl 0.40715

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 429
num_genesets_included 1175

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 205

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.42e-33 2.01e-30 0.815 0.3010 0.75700 1.28e-06 2.23e-34
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.33e-32 9.14e-30 0.723 0.2540 0.67700 6.23e-06 1.67e-33
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 3.32e-27 7.79e-25 0.690 0.2220 0.65300 1.82e-04 3.29e-28
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 2.91e-03 2.09e-02 0.676 -0.2600 -0.62400 1.55e-01 6.32e-04
EUKARYOTIC TRANSLATION INITIATION 114 1.91e-30 5.61e-28 0.663 0.2040 0.63100 1.64e-04 2.28e-31
REDUCTION OF CYTOSOLIC CA LEVELS 11 4.74e-03 3.08e-02 0.650 -0.5570 -0.33600 1.38e-03 5.39e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.51e-03 1.27e-02 0.633 0.1440 0.61600 4.08e-01 3.99e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.32e-06 1.30e-04 0.629 0.6290 -0.00377 7.12e-06 9.79e-01
SELENOAMINO ACID METABOLISM 109 1.35e-24 2.27e-22 0.629 0.2410 0.58100 1.42e-05 1.02e-25
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 6.42e-05 1.01e-03 0.614 0.5810 0.19900 1.17e-05 1.32e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.21e-14 2.52e-12 0.609 0.1620 0.58700 3.14e-02 6.06e-15
CGMP EFFECTS 15 8.01e-04 7.98e-03 0.604 -0.5630 -0.22000 1.60e-04 1.41e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 7.83e-04 7.87e-03 0.604 0.5920 0.12200 2.21e-04 4.47e-01
P75NTR REGULATES AXONOGENESIS 10 1.97e-02 9.17e-02 0.592 -0.4920 -0.33000 7.07e-03 7.09e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.04e-02 5.81e-02 0.587 -0.2020 -0.55100 2.69e-01 2.55e-03
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 2.48e-02 1.06e-01 0.586 -0.3760 -0.45000 3.96e-02 1.38e-02
HDR THROUGH MMEJ ALT NHEJ 10 2.87e-02 1.18e-01 0.572 -0.3550 -0.44900 5.19e-02 1.40e-02
ENDOSOMAL VACUOLAR PATHWAY 11 1.92e-04 2.40e-03 0.567 -0.2760 0.49600 1.13e-01 4.43e-03
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 8.63e-03 4.95e-02 0.564 -0.2340 -0.51300 1.60e-01 2.08e-03
NONSENSE MEDIATED DECAY NMD 109 1.73e-20 2.25e-18 0.564 0.1970 0.52800 3.76e-04 1.52e-21
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.61e-04 3.06e-03 0.557 0.1250 0.54300 3.58e-01 6.65e-05
COMPLEX I BIOGENESIS 56 1.08e-10 6.36e-09 0.557 0.1910 0.52300 1.33e-02 1.31e-11
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.35e-04 3.82e-03 0.553 -0.5160 -0.19800 6.36e-05 1.25e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 5.74e-06 1.38e-04 0.538 -0.3990 -0.36100 1.59e-05 9.64e-05
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.34e-02 1.32e-01 0.529 -0.4740 -0.23500 9.44e-03 1.98e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 8.34e-07 3.09e-05 0.529 0.3240 0.41800 1.45e-04 9.15e-07
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 9.57e-04 9.02e-03 0.528 -0.1550 -0.50500 2.54e-01 2.10e-04
KERATAN SULFATE DEGRADATION 12 2.81e-02 1.17e-01 0.524 0.3260 0.41000 5.02e-02 1.39e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.54e-05 1.14e-03 0.523 0.5120 0.10400 2.12e-05 3.88e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 4.23e-24 6.21e-22 0.521 0.2160 0.47400 2.42e-06 3.75e-25
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 2.21e-02 9.90e-02 0.520 0.4080 0.32200 1.08e-02 4.47e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 1.86e-02 8.72e-02 0.505 -0.0817 -0.49800 6.55e-01 6.36e-03
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 1.86e-02 8.72e-02 0.505 -0.0817 -0.49800 6.55e-01 6.36e-03
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.11e-03 9.99e-03 0.504 -0.2830 -0.41700 1.64e-02 4.05e-04
DSCAM INTERACTIONS 10 5.90e-02 1.95e-01 0.501 -0.2740 -0.42000 1.34e-01 2.16e-02
PHASE 0 RAPID DEPOLARISATION 30 3.54e-04 4.00e-03 0.495 -0.3090 -0.38700 3.45e-03 2.48e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.59e-18 3.04e-16 0.492 0.1600 0.46500 2.00e-03 2.74e-19
TRANSLATION 286 3.50e-34 4.11e-31 0.489 0.2600 0.41400 3.84e-14 1.65e-33
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.34e-06 4.34e-05 0.489 0.3250 0.36500 4.22e-05 4.33e-06
RESPIRATORY ELECTRON TRANSPORT 102 6.65e-15 6.51e-13 0.489 0.1600 0.46200 5.30e-03 7.49e-16
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.88e-02 1.95e-01 0.488 -0.3800 -0.30500 2.89e-02 7.96e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 7.94e-02 2.34e-01 0.484 -0.3050 -0.37600 9.51e-02 3.95e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 9.21e-03 5.20e-02 0.483 0.0844 0.47600 5.98e-01 2.98e-03
STABILIZATION OF P53 54 1.48e-06 4.58e-05 0.481 0.3120 0.36600 7.15e-05 3.23e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.38e-02 1.34e-01 0.479 0.2050 0.43300 2.18e-01 9.43e-03
MITOCHONDRIAL TRANSLATION 93 1.35e-10 7.54e-09 0.478 0.3130 0.36200 1.90e-07 1.65e-09
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 8.32e-03 4.87e-02 0.474 0.4710 0.05160 3.26e-03 7.47e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.19e-02 1.78e-01 0.472 -0.1600 -0.44400 3.81e-01 1.51e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 8.88e-08 4.01e-06 0.470 0.3890 0.26400 4.67e-08 2.14e-04
GLUTATHIONE SYNTHESIS AND RECYCLING 11 7.24e-02 2.21e-01 0.468 0.2850 0.37100 1.02e-01 3.30e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.42e-33 2.01e-30 0.81500 3.01e-01 0.757000 1.28e-06 2.23e-34
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.33e-32 9.14e-30 0.72300 2.54e-01 0.677000 6.23e-06 1.67e-33
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 3.32e-27 7.79e-25 0.69000 2.22e-01 0.653000 1.82e-04 3.29e-28
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 2.91e-03 2.09e-02 0.67600 -2.60e-01 -0.624000 1.55e-01 6.32e-04
EUKARYOTIC TRANSLATION INITIATION 114 1.91e-30 5.61e-28 0.66300 2.04e-01 0.631000 1.64e-04 2.28e-31
REDUCTION OF CYTOSOLIC CA LEVELS 11 4.74e-03 3.08e-02 0.65000 -5.57e-01 -0.336000 1.38e-03 5.39e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.51e-03 1.27e-02 0.63300 1.44e-01 0.616000 4.08e-01 3.99e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.32e-06 1.30e-04 0.62900 6.29e-01 -0.003770 7.12e-06 9.79e-01
SELENOAMINO ACID METABOLISM 109 1.35e-24 2.27e-22 0.62900 2.41e-01 0.581000 1.42e-05 1.02e-25
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 6.42e-05 1.01e-03 0.61400 5.81e-01 0.199000 1.17e-05 1.32e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.21e-14 2.52e-12 0.60900 1.62e-01 0.587000 3.14e-02 6.06e-15
CGMP EFFECTS 15 8.01e-04 7.98e-03 0.60400 -5.63e-01 -0.220000 1.60e-04 1.41e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 7.83e-04 7.87e-03 0.60400 5.92e-01 0.122000 2.21e-04 4.47e-01
P75NTR REGULATES AXONOGENESIS 10 1.97e-02 9.17e-02 0.59200 -4.92e-01 -0.330000 7.07e-03 7.09e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.04e-02 5.81e-02 0.58700 -2.02e-01 -0.551000 2.69e-01 2.55e-03
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 2.48e-02 1.06e-01 0.58600 -3.76e-01 -0.450000 3.96e-02 1.38e-02
HDR THROUGH MMEJ ALT NHEJ 10 2.87e-02 1.18e-01 0.57200 -3.55e-01 -0.449000 5.19e-02 1.40e-02
ENDOSOMAL VACUOLAR PATHWAY 11 1.92e-04 2.40e-03 0.56700 -2.76e-01 0.496000 1.13e-01 4.43e-03
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 8.63e-03 4.95e-02 0.56400 -2.34e-01 -0.513000 1.60e-01 2.08e-03
NONSENSE MEDIATED DECAY NMD 109 1.73e-20 2.25e-18 0.56400 1.97e-01 0.528000 3.76e-04 1.52e-21
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.61e-04 3.06e-03 0.55700 1.25e-01 0.543000 3.58e-01 6.65e-05
COMPLEX I BIOGENESIS 56 1.08e-10 6.36e-09 0.55700 1.91e-01 0.523000 1.33e-02 1.31e-11
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.35e-04 3.82e-03 0.55300 -5.16e-01 -0.198000 6.36e-05 1.25e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 5.74e-06 1.38e-04 0.53800 -3.99e-01 -0.361000 1.59e-05 9.64e-05
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.34e-02 1.32e-01 0.52900 -4.74e-01 -0.235000 9.44e-03 1.98e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 8.34e-07 3.09e-05 0.52900 3.24e-01 0.418000 1.45e-04 9.15e-07
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 9.57e-04 9.02e-03 0.52800 -1.55e-01 -0.505000 2.54e-01 2.10e-04
KERATAN SULFATE DEGRADATION 12 2.81e-02 1.17e-01 0.52400 3.26e-01 0.410000 5.02e-02 1.39e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.54e-05 1.14e-03 0.52300 5.12e-01 0.104000 2.12e-05 3.88e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 4.23e-24 6.21e-22 0.52100 2.16e-01 0.474000 2.42e-06 3.75e-25
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 2.21e-02 9.90e-02 0.52000 4.08e-01 0.322000 1.08e-02 4.47e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 1.86e-02 8.72e-02 0.50500 -8.17e-02 -0.498000 6.55e-01 6.36e-03
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 1.86e-02 8.72e-02 0.50500 -8.17e-02 -0.498000 6.55e-01 6.36e-03
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.11e-03 9.99e-03 0.50400 -2.83e-01 -0.417000 1.64e-02 4.05e-04
DSCAM INTERACTIONS 10 5.90e-02 1.95e-01 0.50100 -2.74e-01 -0.420000 1.34e-01 2.16e-02
PHASE 0 RAPID DEPOLARISATION 30 3.54e-04 4.00e-03 0.49500 -3.09e-01 -0.387000 3.45e-03 2.48e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.59e-18 3.04e-16 0.49200 1.60e-01 0.465000 2.00e-03 2.74e-19
TRANSLATION 286 3.50e-34 4.11e-31 0.48900 2.60e-01 0.414000 3.84e-14 1.65e-33
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.34e-06 4.34e-05 0.48900 3.25e-01 0.365000 4.22e-05 4.33e-06
RESPIRATORY ELECTRON TRANSPORT 102 6.65e-15 6.51e-13 0.48900 1.60e-01 0.462000 5.30e-03 7.49e-16
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.88e-02 1.95e-01 0.48800 -3.80e-01 -0.305000 2.89e-02 7.96e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 7.94e-02 2.34e-01 0.48400 -3.05e-01 -0.376000 9.51e-02 3.95e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 9.21e-03 5.20e-02 0.48300 8.44e-02 0.476000 5.98e-01 2.98e-03
STABILIZATION OF P53 54 1.48e-06 4.58e-05 0.48100 3.12e-01 0.366000 7.15e-05 3.23e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.38e-02 1.34e-01 0.47900 2.05e-01 0.433000 2.18e-01 9.43e-03
MITOCHONDRIAL TRANSLATION 93 1.35e-10 7.54e-09 0.47800 3.13e-01 0.362000 1.90e-07 1.65e-09
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 8.32e-03 4.87e-02 0.47400 4.71e-01 0.051600 3.26e-03 7.47e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.19e-02 1.78e-01 0.47200 -1.60e-01 -0.444000 3.81e-01 1.51e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 8.88e-08 4.01e-06 0.47000 3.89e-01 0.264000 4.67e-08 2.14e-04
GLUTATHIONE SYNTHESIS AND RECYCLING 11 7.24e-02 2.21e-01 0.46800 2.85e-01 0.371000 1.02e-01 3.30e-02
MATURATION OF NUCLEOPROTEIN 10 9.77e-02 2.64e-01 0.46700 -3.42e-01 -0.317000 6.08e-02 8.24e-02
PHASE 4 RESTING MEMBRANE POTENTIAL 14 2.36e-02 1.02e-01 0.46700 -2.01e-01 -0.421000 1.93e-01 6.35e-03
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.84e-02 1.46e-01 0.46500 -4.43e-01 -0.142000 1.10e-02 4.15e-01
HEDGEHOG LIGAND BIOGENESIS 61 8.67e-07 3.09e-05 0.46300 3.09e-01 0.345000 2.98e-05 3.22e-06
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 6.09e-06 1.42e-04 0.46200 3.22e-01 0.331000 5.11e-05 3.07e-05
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 15 3.30e-02 1.32e-01 0.46000 2.98e-01 0.351000 4.59e-02 1.87e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 1.77e-06 5.33e-05 0.45800 2.99e-01 0.347000 7.06e-05 4.13e-06
RA BIOSYNTHESIS PATHWAY 12 7.00e-02 2.16e-01 0.45600 3.22e-01 0.323000 5.35e-02 5.26e-02
DEGRADATION OF AXIN 53 8.04e-06 1.72e-04 0.45500 3.02e-01 0.341000 1.46e-04 1.78e-05
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 6.68e-06 1.48e-04 0.45300 2.90e-01 0.348000 2.23e-04 9.87e-06
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 1.68e-02 8.29e-02 0.45100 2.55e-01 0.372000 6.12e-02 6.25e-03
CELLULAR RESPONSE TO STARVATION 146 2.48e-17 2.65e-15 0.45100 1.67e-01 0.419000 5.16e-04 2.25e-18
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 2.34e-02 1.01e-01 0.45100 -2.76e-01 -0.356000 4.87e-02 1.10e-02
GLUTATHIONE CONJUGATION 29 1.88e-04 2.39e-03 0.44800 1.01e-01 0.437000 3.44e-01 4.72e-05
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.03e-06 5.80e-05 0.44600 3.14e-01 0.317000 1.96e-05 1.57e-05
GAP JUNCTION ASSEMBLY 21 1.86e-03 1.49e-02 0.44500 4.36e-01 0.088000 5.40e-04 4.85e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 1.35e-04 1.80e-03 0.44500 1.53e-01 0.418000 1.23e-01 2.47e-05
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.57e-03 1.95e-02 0.44400 3.85e-01 0.222000 6.88e-04 4.96e-02
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 5.38e-03 3.38e-02 0.44400 1.76e-01 0.407000 1.62e-01 1.23e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 3.19e-06 8.51e-05 0.44400 2.69e-01 0.353000 3.57e-04 2.72e-06
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 4.77e-04 5.15e-03 0.43900 -1.68e-01 -0.406000 1.05e-01 9.20e-05
GLYCOGEN STORAGE DISEASES 12 4.80e-02 1.69e-01 0.43900 4.11e-01 0.156000 1.38e-02 3.49e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 4.71e-02 1.67e-01 0.43800 1.50e-01 0.412000 3.69e-01 1.35e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 3.17e-02 1.28e-01 0.43800 2.01e-01 0.389000 1.79e-01 9.09e-03
ANTIGEN PROCESSING CROSS PRESENTATION 97 2.13e-11 1.32e-09 0.43700 1.48e-01 0.411000 1.20e-02 2.55e-12
IRE1ALPHA ACTIVATES CHAPERONES 50 2.14e-06 5.85e-05 0.43700 4.16e-01 0.134000 3.62e-07 1.01e-01
METABOLISM OF POLYAMINES 57 6.51e-06 1.47e-04 0.43700 2.57e-01 0.353000 7.87e-04 4.02e-06
DEGRADATION OF DVL 55 1.26e-05 2.51e-04 0.43700 2.79e-01 0.336000 3.41e-04 1.66e-05
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 7.19e-04 7.41e-03 0.43100 -1.40e-01 -0.407000 1.92e-01 1.47e-04
SUMOYLATION OF RNA BINDING PROTEINS 45 6.22e-05 9.88e-04 0.43000 -2.14e-01 -0.373000 1.32e-02 1.49e-05
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.18e-04 8.08e-03 0.42900 -1.92e-01 -0.383000 6.03e-02 1.76e-04
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.73e-03 2.00e-02 0.42400 -3.14e-01 0.285000 4.98e-02 7.55e-02
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 8.61e-03 4.95e-02 0.42400 2.01e-01 -0.373000 2.48e-01 3.23e-02
SUMOYLATION OF SUMOYLATION PROTEINS 33 8.40e-04 8.09e-03 0.42300 -1.95e-01 -0.376000 5.24e-02 1.87e-04
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 5.47e-04 5.79e-03 0.42300 -2.25e-01 -0.358000 1.79e-02 1.66e-04
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 1.04e-01 2.74e-01 0.42200 -2.17e-01 -0.362000 2.13e-01 3.74e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 7.94e-03 4.69e-02 0.42100 -3.71e-01 -0.199000 2.08e-03 9.81e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.46e-01 3.39e-01 0.42000 -3.35e-01 -0.253000 6.64e-02 1.67e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 3.87e-03 2.61e-02 0.41900 8.45e-02 0.410000 5.03e-01 1.13e-03
CS DS DEGRADATION 14 2.85e-02 1.18e-01 0.41500 9.42e-02 0.404000 5.42e-01 8.79e-03
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 1.11e-06 3.72e-05 0.41500 3.97e-01 -0.123000 3.81e-05 2.02e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 3.40e-05 5.79e-04 0.41100 2.69e-01 0.311000 4.54e-04 4.99e-05
CELLULAR RESPONSE TO HYPOXIA 72 8.55e-07 3.09e-05 0.41100 2.10e-01 0.353000 2.12e-03 2.23e-07
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 2.78e-02 1.16e-01 0.40900 3.07e-01 0.270000 1.74e-02 3.65e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 2.20e-05 4.03e-04 0.40900 2.48e-01 0.325000 1.00e-03 1.59e-05
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 5.55e-02 1.87e-01 0.40800 -2.55e-01 -0.319000 7.77e-02 2.70e-02
CRISTAE FORMATION 31 9.79e-04 9.13e-03 0.40800 1.32e-01 0.385000 2.02e-01 2.04e-04
INTRAFLAGELLAR TRANSPORT 51 9.69e-06 2.00e-04 0.40400 3.86e-01 0.117000 1.80e-06 1.48e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 1.59e-05 3.01e-04 0.40300 2.55e-01 0.313000 4.70e-04 1.77e-05
NUCLEAR IMPORT OF REV PROTEIN 32 1.35e-03 1.16e-02 0.40300 -1.56e-01 -0.371000 1.26e-01 2.79e-04
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.58e-02 2.44e-01 0.40200 3.50e-01 0.198000 2.90e-02 2.16e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 7.87e-02 2.33e-01 0.39900 2.79e-01 0.285000 6.17e-02 5.57e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 9.56e-02 2.60e-01 0.39700 -3.76e-01 -0.128000 3.07e-02 4.63e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 8.35e-02 2.40e-01 0.39700 -6.17e-02 -0.393000 7.35e-01 3.16e-02
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 1.82e-01 3.91e-01 0.39700 -2.52e-01 -0.306000 1.67e-01 9.33e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 11 9.08e-02 2.52e-01 0.39700 1.17e-01 0.379000 5.03e-01 2.94e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 3.13e-02 1.27e-01 0.39600 -1.46e-01 -0.369000 2.98e-01 8.49e-03
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.50e-02 2.60e-01 0.39600 -2.98e-01 -0.261000 5.36e-02 9.09e-02
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 1.09e-03 9.94e-03 0.39500 -1.50e-01 -0.366000 1.31e-01 2.21e-04
AGGREPHAGY 35 7.03e-05 1.07e-03 0.39500 3.94e-01 0.011000 5.37e-05 9.10e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 14 6.59e-02 2.07e-01 0.39400 -1.60e-01 -0.360000 2.99e-01 1.98e-02
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 40 1.35e-03 1.16e-02 0.39300 2.60e-01 0.295000 4.50e-03 1.24e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.01e-05 2.05e-04 0.39300 2.63e-01 0.292000 1.45e-04 2.46e-05
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 6.54e-02 2.07e-01 0.39200 3.60e-01 0.153000 1.95e-02 3.22e-01
G PROTEIN ACTIVATION 22 3.33e-03 2.35e-02 0.39100 2.75e-02 0.390000 8.23e-01 1.53e-03
SODIUM CALCIUM EXCHANGERS 10 1.01e-01 2.70e-01 0.39000 -3.82e-01 -0.079400 3.65e-02 6.64e-01
LGI ADAM INTERACTIONS 14 4.94e-02 1.72e-01 0.38900 -1.05e-01 -0.375000 4.98e-01 1.52e-02
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.07e-02 5.92e-02 0.38900 -1.39e-01 -0.363000 2.49e-01 2.59e-03
METABOLISM OF AMINO ACIDS AND DERIVATIVES 315 5.66e-25 1.11e-22 0.38700 1.77e-01 0.344000 6.72e-08 9.21e-26
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 3.83e-03 2.61e-02 0.38700 2.77e-02 0.386000 8.22e-01 1.74e-03
INFLUENZA INFECTION 145 3.40e-13 2.35e-11 0.38200 1.18e-01 0.363000 1.45e-02 4.47e-14
RRNA PROCESSING 194 2.22e-14 1.86e-12 0.38000 2.05e-01 0.320000 9.25e-07 1.52e-14
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 33 7.35e-04 7.51e-03 0.37900 7.25e-02 0.372000 4.71e-01 2.16e-04
MITOCHONDRIAL PROTEIN IMPORT 63 6.57e-05 1.02e-03 0.37900 2.58e-01 0.277000 3.92e-04 1.42e-04
G1 S DNA DAMAGE CHECKPOINTS 65 4.50e-05 7.44e-04 0.37800 2.39e-01 0.293000 8.56e-04 4.46e-05
SIGNALING BY FGFR4 IN DISEASE 10 9.92e-02 2.67e-01 0.37700 -3.74e-01 -0.044900 4.03e-02 8.06e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 1.73e-03 1.41e-02 0.37700 -1.44e-01 -0.348000 1.42e-01 3.61e-04
CYTOSOLIC TRNA AMINOACYLATION 24 4.58e-04 5.03e-03 0.37500 3.52e-01 -0.131000 2.87e-03 2.66e-01
DISEASES OF CARBOHYDRATE METABOLISM 28 9.02e-03 5.14e-02 0.37400 3.33e-01 0.171000 2.31e-03 1.17e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 1.40e-01 3.32e-01 0.37400 -2.37e-01 -0.289000 1.39e-01 7.08e-02
RETINOID CYCLE DISEASE EVENTS 10 1.45e-01 3.39e-01 0.37400 1.11e-01 0.357000 5.43e-01 5.06e-02
KERATAN SULFATE KERATIN METABOLISM 30 8.13e-03 4.78e-02 0.37300 3.20e-01 0.192000 2.40e-03 6.86e-02
INTERLEUKIN 6 SIGNALING 10 2.14e-01 4.35e-01 0.37300 2.17e-01 0.304000 2.35e-01 9.60e-02
PCP CE PATHWAY 89 2.07e-06 5.80e-05 0.37200 2.72e-01 0.253000 9.00e-06 3.65e-05
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 6.18e-06 1.42e-04 0.37100 2.38e-01 0.285000 2.11e-04 9.27e-06
ACTIVATION OF MATRIX METALLOPROTEINASES 14 7.44e-02 2.24e-01 0.37000 -1.18e-01 -0.351000 4.44e-01 2.30e-02
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.04e-04 3.54e-03 0.36900 -9.01e-02 -0.358000 3.18e-01 7.27e-05
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 4.50e-02 1.62e-01 0.36900 -2.90e-01 -0.228000 2.16e-02 6.99e-02
MET ACTIVATES RAP1 AND RAC1 10 9.47e-02 2.60e-01 0.36900 -3.68e-01 -0.016300 4.36e-02 9.29e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 20 1.31e-02 6.91e-02 0.36800 4.92e-02 0.365000 7.03e-01 4.76e-03
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.43e-04 1.88e-03 0.36800 -3.68e-01 0.006280 1.35e-04 9.48e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 1.85e-01 3.93e-01 0.36500 1.90e-01 0.312000 2.76e-01 7.28e-02
KERATAN SULFATE BIOSYNTHESIS 24 2.20e-02 9.90e-02 0.36400 3.24e-01 0.166000 6.07e-03 1.58e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.17e-01 4.39e-01 0.36300 1.84e-01 0.313000 3.13e-01 8.65e-02
POTASSIUM CHANNELS 90 3.71e-06 9.70e-05 0.36200 -2.51e-01 -0.261000 3.94e-05 1.92e-05
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 2.48e-02 1.06e-01 0.36200 3.35e-01 0.136000 6.53e-03 2.68e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 1.01e-04 1.49e-03 0.36100 2.34e-01 0.275000 1.02e-03 1.15e-04
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 2.94e-03 2.09e-02 0.36000 -1.58e-01 -0.323000 9.65e-02 6.71e-04
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 6.02e-02 1.98e-01 0.36000 -2.21e-01 -0.283000 8.65e-02 2.83e-02
INTERACTION BETWEEN L1 AND ANKYRINS 28 2.12e-02 9.70e-02 0.35700 -2.27e-01 -0.276000 3.74e-02 1.16e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 6.79e-02 2.12e-01 0.35700 -2.93e-01 -0.204000 2.69e-02 1.25e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 2.17e-01 4.39e-01 0.35700 -2.83e-01 -0.217000 1.04e-01 2.12e-01
REGULATION OF RAS BY GAPS 66 1.03e-04 1.49e-03 0.35600 2.10e-01 0.288000 3.12e-03 5.38e-05
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 58 2.33e-04 2.85e-03 0.35600 -1.87e-01 -0.303000 1.36e-02 6.77e-05
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 1.03e-01 2.72e-01 0.35500 1.32e-01 0.329000 3.94e-01 3.29e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 48 4.41e-06 1.13e-04 0.35400 -6.23e-02 0.349000 4.56e-01 2.91e-05
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 7.10e-02 2.19e-01 0.35400 -3.40e-01 -0.097000 2.26e-02 5.16e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 3.82e-02 1.46e-01 0.35300 -3.53e-01 -0.012700 1.79e-02 9.32e-01
PREGNENOLONE BIOSYNTHESIS 12 1.78e-01 3.88e-01 0.35300 3.03e-01 0.181000 6.89e-02 2.78e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 1.40e-02 7.36e-02 0.35200 -2.00e-01 -0.290000 5.46e-02 5.25e-03
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 5.05e-03 3.24e-02 0.35100 -1.40e-01 -0.322000 1.58e-01 1.15e-03
COHESIN LOADING ONTO CHROMATIN 10 8.78e-02 2.47e-01 0.35000 -3.47e-01 0.045500 5.74e-02 8.03e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.56e-13 1.88e-11 0.35000 1.02e-01 0.335000 2.16e-02 3.83e-14
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 4.41e-02 1.61e-01 0.34900 3.37e-01 0.092600 1.34e-02 4.97e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 12 4.22e-02 1.58e-01 0.34700 -9.65e-02 0.334000 5.63e-01 4.55e-02
ABC TRANSPORTER DISORDERS 70 1.02e-04 1.49e-03 0.34600 2.06e-01 0.279000 2.91e-03 5.56e-05
LONG TERM POTENTIATION 23 4.84e-02 1.69e-01 0.34600 -2.79e-01 -0.205000 2.06e-02 8.81e-02
SIGNALING BY ROBO RECEPTORS 205 2.18e-14 1.86e-12 0.34500 1.26e-01 0.321000 1.82e-03 2.17e-15
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.92e-01 4.01e-01 0.34500 2.57e-01 0.230000 1.09e-01 1.51e-01
DARPP 32 EVENTS 23 5.31e-02 1.81e-01 0.34500 -2.22e-01 -0.264000 6.59e-02 2.85e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 2.25e-02 9.99e-02 0.34400 2.58e-02 0.343000 8.46e-01 9.63e-03
PROLONGED ERK ACTIVATION EVENTS 14 1.33e-01 3.23e-01 0.34300 -3.09e-01 -0.150000 4.55e-02 3.31e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 8.62e-03 4.95e-02 0.34300 -7.93e-02 0.334000 5.50e-01 1.18e-02
RESOLUTION OF D LOOP STRUCTURES 30 1.41e-02 7.36e-02 0.34300 -1.53e-01 -0.306000 1.47e-01 3.67e-03
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 9.85e-03 5.54e-02 0.34200 3.40e-01 -0.041200 8.51e-03 7.50e-01
DAG AND IP3 SIGNALING 40 6.91e-03 4.16e-02 0.34200 -2.45e-01 -0.239000 7.41e-03 8.98e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 7.39e-03 4.41e-02 0.34200 -1.38e-01 0.313000 3.12e-01 2.17e-02
MISMATCH REPAIR 14 1.73e-01 3.81e-01 0.34200 2.21e-01 0.261000 1.53e-01 9.11e-02
PROCESSING OF INTRONLESS PRE MRNAS 19 6.24e-02 2.02e-01 0.34100 -1.39e-01 -0.312000 2.94e-01 1.86e-02
HDMS DEMETHYLATE HISTONES 28 3.02e-02 1.23e-01 0.34100 -2.18e-01 -0.262000 4.61e-02 1.64e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.77e-01 3.87e-01 0.33900 -1.04e-01 -0.323000 5.50e-01 6.39e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 7.72e-02 2.30e-01 0.33800 -3.19e-01 0.110000 8.06e-02 5.47e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 4.79e-02 1.69e-01 0.33600 2.74e-02 0.335000 8.49e-01 2.02e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 10 2.92e-01 5.26e-01 0.33600 -2.65e-01 -0.207000 1.46e-01 2.58e-01
METABOLISM OF STEROID HORMONES 21 6.75e-02 2.11e-01 0.33600 2.85e-01 0.178000 2.39e-02 1.58e-01
CA DEPENDENT EVENTS 36 1.30e-02 6.89e-02 0.33500 -2.58e-01 -0.213000 7.34e-03 2.70e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 2.99e-05 5.17e-04 0.33500 1.90e-01 0.275000 2.57e-03 1.32e-05
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 83 2.83e-05 4.96e-04 0.33300 1.74e-01 0.284000 6.14e-03 8.06e-06
ARACHIDONIC ACID METABOLISM 38 4.77e-04 5.15e-03 0.33300 -5.62e-03 0.333000 9.52e-01 3.89e-04
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 8.78e-02 2.47e-01 0.33200 -1.21e-01 -0.309000 3.87e-01 2.74e-02
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.89e-04 2.39e-03 0.33200 -2.20e-01 -0.248000 1.16e-03 2.45e-04
TNFR2 NON CANONICAL NF KB PATHWAY 79 1.12e-04 1.55e-03 0.32900 2.24e-01 0.241000 5.79e-04 2.14e-04
COMPLEMENT CASCADE 25 1.42e-02 7.36e-02 0.32900 4.97e-02 0.325000 6.67e-01 4.94e-03
SULFUR AMINO ACID METABOLISM 22 7.40e-02 2.23e-01 0.32800 1.95e-01 0.264000 1.14e-01 3.18e-02
FCERI MEDIATED NF KB ACTIVATION 77 1.05e-04 1.49e-03 0.32600 1.79e-01 0.272000 6.56e-03 3.69e-05
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 2.23e-02 9.95e-02 0.32600 -4.46e-02 0.322000 7.43e-01 1.79e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.38e-02 2.40e-01 0.32500 2.69e-01 0.182000 3.25e-02 1.50e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 6.06e-02 1.98e-01 0.32400 -1.63e-01 -0.280000 1.76e-01 2.00e-02
ACTIVATION OF BH3 ONLY PROTEINS 30 1.75e-02 8.39e-02 0.32400 -1.22e-01 -0.300000 2.47e-01 4.44e-03
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 3.81e-02 1.46e-01 0.32300 2.02e-01 0.252000 5.96e-02 1.90e-02
HEME SIGNALING 45 3.28e-03 2.32e-02 0.32200 -2.90e-01 -0.140000 7.50e-04 1.04e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.57e-02 7.88e-02 0.32100 -2.07e-01 0.246000 1.53e-01 8.86e-02
SHC1 EVENTS IN EGFR SIGNALING 11 6.33e-02 2.04e-01 0.32000 -2.73e-01 0.168000 1.18e-01 3.36e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.68e-01 3.74e-01 0.31800 -1.86e-01 -0.258000 1.97e-01 7.42e-02
ERBB2 REGULATES CELL MOTILITY 14 3.25e-02 1.30e-01 0.31700 -2.75e-01 0.158000 7.48e-02 3.05e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 151 8.88e-09 4.54e-07 0.31500 1.31e-01 0.287000 5.67e-03 1.19e-09
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 3.44e-02 1.36e-01 0.31400 3.06e-01 0.067500 1.10e-02 5.75e-01
HEDGEHOG ON STATE 82 1.70e-04 2.20e-03 0.31400 1.98e-01 0.243000 1.95e-03 1.42e-04
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 4.63e-02 1.67e-01 0.31300 -3.06e-01 -0.067500 1.52e-02 5.92e-01
REGULATION OF TNFR1 SIGNALING 34 2.79e-02 1.16e-01 0.31200 1.97e-01 0.242000 4.64e-02 1.46e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 2.82e-01 5.16e-01 0.31200 1.97e-01 0.243000 2.39e-01 1.45e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 6.36e-02 2.04e-01 0.31100 8.16e-02 0.300000 5.27e-01 2.02e-02
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 4.77e-02 1.69e-01 0.31100 3.72e-02 -0.308000 7.97e-01 3.27e-02
ACYL CHAIN REMODELLING OF PC 16 4.70e-02 1.67e-01 0.30800 -4.64e-02 0.305000 7.48e-01 3.50e-02
PROTEIN METHYLATION 17 1.07e-01 2.77e-01 0.30800 8.99e-02 0.294000 5.21e-01 3.56e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 6.28e-02 2.03e-01 0.30700 3.48e-02 -0.305000 8.16e-01 4.10e-02
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 2.17e-01 4.39e-01 0.30700 -2.65e-01 -0.154000 8.61e-02 3.18e-01
CARDIAC CONDUCTION 109 1.93e-05 3.61e-04 0.30600 -2.20e-01 -0.213000 7.14e-05 1.22e-04
PINK1 PRKN MEDIATED MITOPHAGY 22 8.19e-02 2.37e-01 0.30600 1.35e-01 0.274000 2.74e-01 2.59e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 1.49e-02 7.63e-02 0.30600 -3.42e-02 0.304000 7.77e-01 1.17e-02
HEDGEHOG OFF STATE 106 7.65e-06 1.67e-04 0.30500 2.71e-01 0.139000 1.42e-06 1.34e-02
SHC1 EVENTS IN ERBB2 SIGNALING 21 1.28e-02 6.85e-02 0.30500 -2.89e-01 0.096800 2.20e-02 4.43e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.26e-04 1.70e-03 0.30400 3.00e-01 -0.048800 3.23e-04 5.59e-01
INITIAL TRIGGERING OF COMPLEMENT 11 1.66e-01 3.70e-01 0.30400 5.36e-03 0.304000 9.75e-01 8.12e-02
TRNA AMINOACYLATION 42 1.13e-03 1.01e-02 0.30300 3.03e-01 0.008300 6.71e-04 9.26e-01
G PROTEIN MEDIATED EVENTS 52 4.88e-03 3.15e-02 0.30300 -2.50e-01 -0.172000 1.81e-03 3.22e-02
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 3.00e-01 5.35e-01 0.30300 2.42e-01 0.182000 1.46e-01 2.76e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 5.99e-02 1.97e-01 0.30300 -3.02e-01 -0.018100 2.65e-02 8.94e-01
ACTIVATION OF RAC1 13 2.81e-01 5.16e-01 0.30200 -2.27e-01 -0.199000 1.57e-01 2.13e-01
HS GAG DEGRADATION 21 6.63e-02 2.08e-01 0.30200 2.91e-01 0.080400 2.11e-02 5.24e-01
LYSINE CATABOLISM 11 2.38e-01 4.67e-01 0.30100 7.62e-02 0.291000 6.62e-01 9.42e-02
SIGNAL AMPLIFICATION 30 6.13e-03 3.79e-02 0.30100 -1.59e-02 0.301000 8.80e-01 4.36e-03
INTERLEUKIN 7 SIGNALING 19 1.66e-02 8.21e-02 0.30000 1.37e-01 -0.267000 3.00e-01 4.38e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 25 1.07e-02 5.92e-02 0.30000 -4.56e-02 0.297000 6.93e-01 1.03e-02
METABOLISM OF FAT SOLUBLE VITAMINS 35 2.29e-02 1.01e-01 0.30000 2.67e-01 0.137000 6.36e-03 1.60e-01
JOSEPHIN DOMAIN DUBS 11 2.71e-01 5.06e-01 0.29800 2.81e-01 0.101000 1.07e-01 5.63e-01
RHO GTPASES ACTIVATE CIT 18 4.98e-02 1.73e-01 0.29800 -1.57e-02 0.298000 9.08e-01 2.87e-02
POLYMERASE SWITCHING 14 2.60e-01 4.98e-01 0.29800 1.88e-01 0.232000 2.25e-01 1.33e-01
IRAK4 DEFICIENCY TLR2 4 13 5.73e-02 1.91e-01 0.29800 -1.68e-01 0.246000 2.95e-01 1.24e-01
NETRIN 1 SIGNALING 49 5.32e-03 3.38e-02 0.29800 -1.34e-01 -0.266000 1.05e-01 1.29e-03
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 3.15e-01 5.43e-01 0.29700 1.78e-01 0.238000 2.87e-01 1.54e-01
GLYCOLYSIS 66 1.37e-06 4.34e-05 0.29600 1.21e-01 -0.270000 8.95e-02 1.49e-04
CYTOPROTECTION BY HMOX1 119 4.74e-06 1.18e-04 0.29500 1.38e-01 0.261000 9.29e-03 9.23e-07
ERBB2 ACTIVATES PTK6 SIGNALING 11 1.49e-01 3.45e-01 0.29500 -2.92e-01 0.040000 9.36e-02 8.18e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 9.12e-02 2.52e-01 0.29500 -6.74e-02 0.287000 6.74e-01 7.34e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.44e-01 4.76e-01 0.29400 -1.80e-01 -0.232000 2.28e-01 1.19e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 1.53e-02 7.74e-02 0.29200 5.40e-02 0.287000 5.97e-01 4.92e-03
INTERLEUKIN 15 SIGNALING 12 1.81e-01 3.90e-01 0.29200 -2.46e-02 -0.291000 8.83e-01 8.14e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 6.01e-04 6.30e-03 0.29200 1.15e-01 0.268000 9.98e-02 1.18e-04
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 7.13e-02 2.19e-01 0.29100 2.59e-01 0.133000 2.25e-02 2.40e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 2.92e-02 1.20e-01 0.29100 2.35e-01 0.171000 1.21e-02 6.82e-02
FCERI MEDIATED CA 2 MOBILIZATION 26 1.95e-02 9.13e-02 0.29000 -2.90e-01 0.001030 1.05e-02 9.93e-01
OLFACTORY SIGNALING PATHWAY 25 6.39e-02 2.05e-01 0.28900 -2.71e-01 -0.102000 1.91e-02 3.77e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.54e-01 4.91e-01 0.28900 -1.76e-01 -0.229000 2.37e-01 1.24e-01
TRAFFICKING OF AMPA RECEPTORS 31 5.11e-02 1.75e-01 0.28900 -1.50e-01 -0.247000 1.48e-01 1.72e-02
CHOLESTEROL BIOSYNTHESIS 24 2.21e-02 9.90e-02 0.28900 2.88e-01 -0.021200 1.45e-02 8.57e-01
SIGNALING BY LEPTIN 10 3.24e-01 5.52e-01 0.28900 2.73e-01 0.093200 1.34e-01 6.10e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 1.25e-01 3.10e-01 0.28800 -2.22e-01 0.183000 2.25e-01 3.16e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 10 4.07e-01 6.28e-01 0.28800 -1.77e-01 -0.227000 3.33e-01 2.14e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 5.61e-02 1.89e-01 0.28700 -2.49e-01 -0.143000 1.82e-02 1.75e-01
FGFR2 ALTERNATIVE SPLICING 25 1.01e-01 2.70e-01 0.28700 1.62e-01 0.237000 1.60e-01 4.07e-02
PHASE I FUNCTIONALIZATION OF COMPOUNDS 61 1.34e-03 1.16e-02 0.28700 9.92e-02 0.269000 1.80e-01 2.79e-04
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.79e-01 3.88e-01 0.28500 -1.62e-01 -0.235000 2.21e-01 7.63e-02
GAP JUNCTION TRAFFICKING AND REGULATION 33 1.50e-02 7.65e-02 0.28500 2.81e-01 0.044700 5.18e-03 6.57e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 7.65e-02 2.29e-01 0.28400 -2.44e-01 0.147000 1.28e-01 3.60e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 7.14e-02 2.19e-01 0.28400 -1.15e-01 -0.260000 3.11e-01 2.17e-02
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.27e-01 3.15e-01 0.28400 -2.69e-01 -0.092400 4.27e-02 4.86e-01
BIOLOGICAL OXIDATIONS 125 9.58e-07 3.31e-05 0.28300 8.24e-02 0.271000 1.12e-01 1.68e-07
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 2.73e-03 2.00e-02 0.28300 1.45e-01 0.243000 4.48e-02 7.66e-04
PEXOPHAGY 11 3.45e-01 5.68e-01 0.28300 2.53e-01 0.128000 1.47e-01 4.62e-01
TRANSCRIPTIONAL REGULATION BY MECP2 59 1.67e-03 1.38e-02 0.28200 -2.68e-01 -0.087700 3.67e-04 2.44e-01
UCH PROTEINASES 89 5.01e-04 5.35e-03 0.28200 1.80e-01 0.217000 3.42e-03 3.95e-04
PHASE 2 PLATEAU PHASE 12 1.78e-01 3.88e-01 0.28100 3.81e-03 -0.281000 9.82e-01 9.17e-02
ADHERENS JUNCTIONS INTERACTIONS 30 7.99e-02 2.34e-01 0.28100 -2.08e-01 -0.189000 4.91e-02 7.29e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 92 1.68e-04 2.19e-03 0.28000 1.26e-01 0.250000 3.73e-02 3.37e-05
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 9.08e-03 5.16e-02 0.27800 -2.02e-01 0.192000 8.66e-02 1.04e-01
PARASITE INFECTION 55 4.30e-04 4.82e-03 0.27800 -2.78e-01 0.006180 3.67e-04 9.37e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 7.56e-04 7.66e-03 0.27800 1.33e-01 0.244000 4.17e-02 1.77e-04
RET SIGNALING 37 7.74e-03 4.59e-02 0.27800 -1.73e-02 -0.277000 8.56e-01 3.53e-03
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.16e-01 2.94e-01 0.27700 -1.13e-01 0.253000 5.00e-01 1.29e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 8.88e-02 2.49e-01 0.27700 -2.75e-01 0.033000 5.66e-02 8.19e-01
INTERLEUKIN 1 SIGNALING 96 3.32e-04 3.82e-03 0.27700 1.68e-01 0.221000 4.51e-03 1.90e-04
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 2.73e-01 5.06e-01 0.27600 7.51e-02 0.266000 6.52e-01 1.10e-01
PEROXISOMAL PROTEIN IMPORT 57 2.12e-03 1.65e-02 0.27600 7.40e-02 0.266000 3.34e-01 5.11e-04
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 1.01e-03 9.29e-03 0.27600 1.72e-01 0.216000 6.45e-03 6.39e-04
SUMOYLATION OF DNA REPLICATION PROTEINS 42 1.73e-02 8.34e-02 0.27500 -1.07e-01 -0.254000 2.32e-01 4.40e-03
PROTEIN LOCALIZATION 156 1.89e-06 5.54e-05 0.27500 1.51e-01 0.230000 1.18e-03 7.22e-07
SIGNALING BY NOTCH4 83 9.86e-04 9.13e-03 0.27400 1.54e-01 0.226000 1.54e-02 3.63e-04
AMINE LIGAND BINDING RECEPTORS 29 5.99e-02 1.97e-01 0.27400 -2.55e-01 -0.101000 1.76e-02 3.48e-01
ORC1 REMOVAL FROM CHROMATIN 67 2.61e-03 1.95e-02 0.27400 1.29e-01 0.241000 6.88e-02 6.34e-04
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 3.89e-01 6.13e-01 0.27300 1.42e-01 0.234000 4.14e-01 1.80e-01
GLUCONEOGENESIS 27 2.26e-02 9.99e-02 0.27200 2.72e-01 -0.018200 1.45e-02 8.70e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 1.49e-01 3.45e-01 0.27100 -2.71e-01 -0.013200 6.91e-02 9.29e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 2.25e-01 4.46e-01 0.27100 -1.06e-01 -0.249000 4.64e-01 8.41e-02
NCAM1 INTERACTIONS 41 2.92e-03 2.09e-02 0.27100 2.75e-02 -0.269000 7.61e-01 2.84e-03
PHASE II CONJUGATION OF COMPOUNDS 61 9.45e-04 9.02e-03 0.27000 4.31e-02 0.267000 5.60e-01 3.13e-04
METHYLATION 12 3.39e-01 5.67e-01 0.27000 1.13e-01 0.245000 4.97e-01 1.42e-01
ZINC TRANSPORTERS 16 1.28e-01 3.15e-01 0.27000 -2.70e-01 -0.005530 6.18e-02 9.69e-01
GLUCOSE METABOLISM 80 7.56e-07 2.96e-05 0.26900 1.37e-01 -0.232000 3.48e-02 3.31e-04
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 4.28e-01 6.52e-01 0.26900 1.89e-01 0.191000 2.77e-01 2.72e-01
FATTY ACID METABOLISM 145 1.45e-07 5.87e-06 0.26800 5.19e-02 0.263000 2.81e-01 4.51e-08
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 3.65e-03 2.55e-02 0.26800 -2.03e-01 -0.176000 2.75e-03 9.51e-03
SIGNALING BY ERBB2 IN CANCER 25 2.96e-02 1.21e-01 0.26700 -2.65e-01 0.033400 2.19e-02 7.73e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 6.25e-02 2.02e-01 0.26600 1.06e-01 0.244000 3.08e-01 1.86e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 3.39e-01 5.67e-01 0.26600 1.02e-01 0.245000 5.39e-01 1.41e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 3.32e-01 5.60e-01 0.26500 -2.48e-01 -0.095800 1.38e-01 5.66e-01
HSF1 ACTIVATION 25 8.37e-02 2.40e-01 0.26500 2.55e-01 0.072900 2.72e-02 5.28e-01
NUCLEOBASE CATABOLISM 31 3.24e-02 1.30e-01 0.26500 3.93e-02 0.262000 7.05e-01 1.17e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 2.06e-03 1.62e-02 0.26400 1.65e-01 0.207000 9.77e-03 1.23e-03
PEROXISOMAL LIPID METABOLISM 26 7.31e-02 2.22e-01 0.26400 6.63e-02 0.256000 5.58e-01 2.39e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 1.72e-01 3.81e-01 0.26400 -1.03e-03 0.264000 9.95e-01 8.73e-02
CELL CELL JUNCTION ORGANIZATION 49 2.56e-02 1.09e-01 0.26400 -2.02e-01 -0.170000 1.44e-02 4.01e-02
PURINE CATABOLISM 16 1.23e-01 3.07e-01 0.26300 -1.69e-02 0.263000 9.07e-01 6.88e-02
INSULIN PROCESSING 24 1.57e-01 3.57e-01 0.26300 -2.17e-01 -0.149000 6.59e-02 2.06e-01
NEUROTRANSMITTER RELEASE CYCLE 49 2.28e-02 1.00e-01 0.26300 -2.18e-01 -0.147000 8.34e-03 7.45e-02
SIGNALING BY PDGFR IN DISEASE 20 2.20e-01 4.41e-01 0.26200 -2.12e-01 -0.155000 1.01e-01 2.31e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.01e-01 2.70e-01 0.26200 -8.06e-02 0.250000 5.89e-01 9.42e-02
SIGNALING BY BMP 25 6.82e-02 2.12e-01 0.26200 -2.59e-01 -0.042200 2.51e-02 7.15e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 4.41e-02 1.61e-01 0.26100 1.24e-01 -0.230000 3.51e-01 8.24e-02
METAL ION SLC TRANSPORTERS 25 4.72e-02 1.67e-01 0.26100 -2.61e-01 -0.001060 2.38e-02 9.93e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 1.15e-01 2.94e-01 0.26100 -2.20e-01 -0.141000 4.41e-02 1.97e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 4.35e-02 1.61e-01 0.26100 -3.76e-02 0.258000 7.55e-01 3.22e-02
DNA REPLICATION PRE INITIATION 79 2.22e-03 1.69e-02 0.26100 1.37e-01 0.222000 3.51e-02 6.60e-04
MAPK6 MAPK4 SIGNALING 83 9.60e-04 9.02e-03 0.26000 1.09e-01 0.236000 8.65e-02 1.98e-04
FCERI MEDIATED MAPK ACTIVATION 28 1.20e-01 3.01e-01 0.25900 -2.18e-01 -0.141000 4.63e-02 1.98e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.31e-01 3.21e-01 0.25900 -1.77e-01 0.188000 2.87e-01 2.59e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 3.82e-01 6.07e-01 0.25900 -1.19e-01 -0.230000 4.75e-01 1.69e-01
MRNA SPLICING MINOR PATHWAY 52 2.30e-02 1.01e-01 0.25900 2.04e-01 0.159000 1.10e-02 4.75e-02
TIE2 SIGNALING 17 9.29e-02 2.56e-01 0.25800 -2.53e-01 0.053600 7.12e-02 7.02e-01
GLYCOSPHINGOLIPID METABOLISM 38 4.50e-02 1.62e-01 0.25800 1.12e-01 0.233000 2.31e-01 1.31e-02
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 1.19e-01 3.01e-01 0.25800 -2.56e-01 -0.036500 4.77e-02 7.78e-01
NUCLEAR ENVELOPE BREAKDOWN 49 1.83e-02 8.69e-02 0.25800 -1.12e-01 -0.233000 1.76e-01 4.80e-03
CROSSLINKING OF COLLAGEN FIBRILS 16 8.37e-02 2.40e-01 0.25800 2.37e-01 -0.102000 1.01e-01 4.80e-01
INTERFERON ALPHA BETA SIGNALING 55 1.04e-04 1.49e-03 0.25700 -1.83e-01 0.180000 1.86e-02 2.09e-02
UNFOLDED PROTEIN RESPONSE UPR 86 2.53e-04 3.03e-03 0.25600 2.50e-01 0.058600 6.36e-05 3.48e-01
DISEASES OF IMMUNE SYSTEM 24 3.79e-02 1.46e-01 0.25500 -5.30e-02 0.250000 6.53e-01 3.42e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 8.92e-02 2.49e-01 0.25500 -2.55e-01 0.010400 4.84e-02 9.36e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 2.85e-01 5.19e-01 0.25500 -2.49e-01 -0.055400 1.21e-01 7.30e-01
SIGNALING BY HIPPO 20 1.89e-01 3.98e-01 0.25500 -2.36e-01 -0.095600 6.78e-02 4.59e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 9.11e-02 2.52e-01 0.25500 2.19e-01 0.129000 3.18e-02 2.06e-01
EFFECTS OF PIP2 HYDROLYSIS 27 1.56e-01 3.55e-01 0.25400 -1.72e-01 -0.187000 1.22e-01 9.28e-02
COLLAGEN CHAIN TRIMERIZATION 40 2.22e-03 1.69e-02 0.25400 1.12e-01 -0.228000 2.22e-01 1.26e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 6.60e-02 2.07e-01 0.25300 -7.84e-02 0.241000 5.54e-01 6.90e-02
FORMATION OF APOPTOSOME 10 2.21e-01 4.41e-01 0.25300 -1.07e-01 0.229000 5.57e-01 2.09e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 3.03e-01 5.36e-01 0.25300 -1.05e-01 -0.230000 4.80e-01 1.23e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 1.51e-01 3.47e-01 0.25200 -1.43e-01 0.207000 3.90e-01 2.14e-01
PYRIMIDINE SALVAGE 10 3.89e-01 6.13e-01 0.25200 2.46e-01 0.053500 1.78e-01 7.70e-01
RORA ACTIVATES GENE EXPRESSION 18 7.88e-02 2.33e-01 0.25100 -2.39e-01 0.079000 7.95e-02 5.62e-01
CA2 PATHWAY 57 2.60e-04 3.06e-03 0.25100 -2.34e-01 0.092500 2.28e-03 2.27e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 58 1.01e-02 5.66e-02 0.25100 -1.01e-01 -0.230000 1.83e-01 2.45e-03
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 2.55e-01 4.91e-01 0.25100 1.97e-01 0.156000 1.28e-01 2.27e-01
ION HOMEOSTASIS 49 3.68e-02 1.43e-01 0.25100 -1.89e-01 -0.165000 2.20e-02 4.59e-02
RAP1 SIGNALLING 15 3.60e-01 5.85e-01 0.25100 -1.95e-01 -0.157000 1.90e-01 2.92e-01
NEURONAL SYSTEM 368 2.12e-11 1.32e-09 0.25000 -1.55e-01 -0.197000 3.75e-07 9.22e-11
CLEC7A DECTIN 1 SIGNALING 95 8.38e-04 8.09e-03 0.25000 1.16e-01 0.222000 5.07e-02 1.88e-04
GLYCOGEN METABOLISM 25 1.82e-01 3.91e-01 0.25000 1.53e-01 0.198000 1.86e-01 8.63e-02
ELASTIC FIBRE FORMATION 38 3.98e-02 1.49e-01 0.25000 7.87e-02 0.237000 4.01e-01 1.14e-02
HSF1 DEPENDENT TRANSACTIVATION 33 3.81e-02 1.46e-01 0.25000 2.47e-01 0.036100 1.40e-02 7.20e-01
HYALURONAN UPTAKE AND DEGRADATION 11 4.66e-01 6.81e-01 0.24900 1.40e-01 0.206000 4.22e-01 2.36e-01
ATTENUATION PHASE 23 1.13e-01 2.89e-01 0.24900 2.45e-01 0.046100 4.21e-02 7.02e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 1.05e-01 2.75e-01 0.24900 2.16e-01 -0.123000 1.47e-01 4.10e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 1.17e-01 2.95e-01 0.24800 -2.28e-01 0.097500 1.26e-01 5.13e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 1.86e-01 3.94e-01 0.24800 4.76e-02 0.243000 7.27e-01 7.39e-02
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 1.60e-02 7.99e-02 0.24700 -2.32e-02 0.246000 8.12e-01 1.17e-02
RHO GTPASES ACTIVATE IQGAPS 24 1.07e-01 2.77e-01 0.24700 2.43e-01 0.046000 3.96e-02 6.96e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.54e-01 6.77e-01 0.24700 -9.13e-02 -0.229000 6.17e-01 2.09e-01
PLATELET CALCIUM HOMEOSTASIS 26 1.81e-01 3.90e-01 0.24600 -1.50e-01 -0.195000 1.86e-01 8.54e-02
INFLAMMASOMES 19 2.85e-01 5.19e-01 0.24600 1.48e-01 0.197000 2.65e-01 1.38e-01
ANTIMICROBIAL PEPTIDES 18 3.10e-01 5.42e-01 0.24500 1.55e-01 0.191000 2.56e-01 1.62e-01
PI METABOLISM 79 6.22e-03 3.83e-02 0.24500 -1.60e-01 -0.186000 1.39e-02 4.33e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.29e-01 4.52e-01 0.24500 1.66e-01 0.180000 1.69e-01 1.34e-01
NUCLEOTIDE SALVAGE 21 2.16e-01 4.38e-01 0.24500 2.20e-01 0.107000 8.10e-02 3.96e-01
SIGNALING BY HEDGEHOG 141 4.57e-05 7.47e-04 0.24400 2.17e-01 0.111000 8.97e-06 2.27e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 4.73e-01 6.85e-01 0.24200 1.21e-01 0.209000 4.86e-01 2.29e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 10 5.36e-01 7.30e-01 0.24200 -1.72e-01 -0.170000 3.45e-01 3.52e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 3.97e-02 1.49e-01 0.24100 -1.76e-01 -0.165000 2.80e-02 3.95e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 94 2.03e-03 1.62e-02 0.24100 1.28e-01 0.204000 3.19e-02 6.18e-04
SEMA4D IN SEMAPHORIN SIGNALING 24 2.24e-01 4.44e-01 0.24100 1.58e-01 0.183000 1.81e-01 1.22e-01
GLYCOGEN SYNTHESIS 14 4.05e-01 6.26e-01 0.24100 1.37e-01 0.198000 3.73e-01 1.99e-01
RAS PROCESSING 24 1.56e-01 3.55e-01 0.24100 8.08e-02 0.227000 4.93e-01 5.41e-02
APOPTOTIC FACTOR MEDIATED RESPONSE 18 8.42e-02 2.40e-01 0.24100 -1.05e-01 0.217000 4.42e-01 1.11e-01
AURKA ACTIVATION BY TPX2 71 8.37e-04 8.09e-03 0.24100 -1.11e-02 -0.240000 8.72e-01 4.64e-04
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 5.13e-03 3.28e-02 0.23900 2.33e-01 -0.051100 7.40e-03 5.58e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 2.33e-01 4.57e-01 0.23900 1.71e-01 0.167000 1.48e-01 1.57e-01
INTERFERON GAMMA SIGNALING 77 3.57e-05 5.99e-04 0.23900 -2.18e-01 0.097900 9.67e-04 1.38e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 3.13e-01 5.43e-01 0.23900 1.82e-01 0.154000 1.69e-01 2.46e-01
GAB1 SIGNALOSOME 14 3.12e-01 5.43e-01 0.23800 -2.31e-01 -0.054000 1.34e-01 7.26e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 8.28e-02 2.40e-01 0.23700 -9.31e-02 -0.218000 3.41e-01 2.57e-02
VLDLR INTERNALISATION AND DEGRADATION 12 3.30e-01 5.59e-01 0.23700 2.35e-01 0.024400 1.58e-01 8.84e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 2.96e-01 5.28e-01 0.23600 -1.88e-01 -0.144000 1.46e-01 2.66e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 3.83e-03 2.61e-02 0.23600 1.17e-01 0.205000 5.99e-02 1.03e-03
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.05e-02 2.52e-01 0.23600 -2.28e-01 0.061300 7.82e-02 6.35e-01
SIGNALING BY FGFR1 IN DISEASE 33 1.24e-01 3.10e-01 0.23500 -2.00e-01 -0.123000 4.64e-02 2.22e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.48e-01 5.72e-01 0.23500 -1.69e-01 -0.163000 2.15e-01 2.32e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 6.51e-04 6.77e-03 0.23400 2.26e-01 -0.060900 2.08e-03 4.07e-01
ACYL CHAIN REMODELLING OF PE 16 1.16e-01 2.95e-01 0.23400 -1.24e-01 0.199000 3.90e-01 1.69e-01
RMTS METHYLATE HISTONE ARGININES 44 4.69e-02 1.67e-01 0.23400 2.16e-01 0.091300 1.34e-02 2.95e-01
VIRAL MESSENGER RNA SYNTHESIS 42 2.67e-02 1.13e-01 0.23400 -3.46e-02 -0.231000 6.98e-01 9.58e-03
SIGNALING BY FLT3 FUSION PROTEINS 19 2.91e-01 5.26e-01 0.23300 -2.07e-01 -0.108000 1.19e-01 4.14e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 3.05e-01 5.36e-01 0.23300 -7.19e-02 -0.222000 6.19e-01 1.25e-01
PLASMA LIPOPROTEIN CLEARANCE 28 1.64e-01 3.68e-01 0.23300 2.06e-01 0.109000 5.96e-02 3.17e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 2.88e-01 5.21e-01 0.23300 8.96e-02 0.215000 5.11e-01 1.14e-01
GLUCAGON TYPE LIGAND RECEPTORS 25 1.38e-01 3.29e-01 0.23300 5.45e-02 0.226000 6.37e-01 5.04e-02
INTERLEUKIN 10 SIGNALING 19 1.38e-01 3.29e-01 0.23200 -2.31e-01 0.021600 8.08e-02 8.70e-01
DEADENYLATION OF MRNA 25 1.37e-01 3.28e-01 0.23200 -2.26e-01 -0.052000 5.01e-02 6.52e-01
RHOJ GTPASE CYCLE 54 2.60e-02 1.10e-01 0.23200 -2.12e-01 -0.093500 6.94e-03 2.35e-01
PROTEIN FOLDING 89 6.03e-03 3.77e-02 0.23200 1.74e-01 0.154000 4.61e-03 1.22e-02
DISEASES OF METABOLISM 197 8.62e-06 1.81e-04 0.23200 1.91e-01 0.132000 4.06e-06 1.39e-03
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 3.01e-01 5.35e-01 0.23200 -1.64e-01 -0.164000 1.93e-01 1.94e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 6.04e-02 1.98e-01 0.23200 -2.08e-01 -0.102000 1.83e-02 2.47e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 1.70e-01 3.78e-01 0.23100 1.89e-01 0.133000 7.36e-02 2.07e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 12 2.66e-01 5.04e-01 0.23100 4.36e-02 -0.227000 7.94e-01 1.74e-01
GABA RECEPTOR ACTIVATION 53 3.11e-02 1.27e-01 0.23000 -2.09e-01 -0.097600 8.57e-03 2.19e-01
EARLY PHASE OF HIV LIFE CYCLE 13 4.64e-01 6.81e-01 0.23000 -1.90e-01 -0.130000 2.36e-01 4.18e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.92e-01 4.01e-01 0.23000 1.47e-01 0.177000 1.71e-01 9.96e-02
BUDDING AND MATURATION OF HIV VIRION 27 1.92e-01 4.01e-01 0.22900 1.99e-01 0.115000 7.42e-02 3.02e-01
ACTIVATION OF SMO 16 3.43e-01 5.68e-01 0.22900 2.11e-01 0.088700 1.43e-01 5.39e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.01e-01 2.70e-01 0.22800 -1.84e-01 -0.135000 4.38e-02 1.39e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 4.83e-01 6.91e-01 0.22800 1.46e-01 0.175000 3.61e-01 2.75e-01
DAP12 INTERACTIONS 31 1.72e-02 8.34e-02 0.22800 -1.66e-01 0.156000 1.10e-01 1.33e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 12 2.63e-01 5.02e-01 0.22700 -5.93e-02 0.219000 7.22e-01 1.89e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 4.71e-01 6.84e-01 0.22600 1.90e-01 0.123000 2.36e-01 4.42e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 4.41e-02 1.61e-01 0.22500 -5.22e-02 0.219000 6.27e-01 4.13e-02
RECYCLING PATHWAY OF L1 40 1.47e-02 7.53e-02 0.22500 2.20e-01 -0.045700 1.59e-02 6.17e-01
DNA METHYLATION 21 3.04e-01 5.36e-01 0.22500 1.25e-01 0.187000 3.23e-01 1.38e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 64 2.61e-02 1.10e-01 0.22400 1.90e-01 0.120000 8.73e-03 9.80e-02
RNA POLYMERASE III CHAIN ELONGATION 18 2.21e-01 4.41e-01 0.22400 2.23e-01 0.019000 1.01e-01 8.89e-01
ERK MAPK TARGETS 22 3.02e-01 5.36e-01 0.22400 -1.38e-01 -0.176000 2.62e-01 1.52e-01
RHOQ GTPASE CYCLE 58 2.04e-02 9.44e-02 0.22400 -2.11e-01 -0.073600 5.37e-03 3.32e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 2.52e-01 4.90e-01 0.22300 -1.61e-01 -0.154000 1.55e-01 1.73e-01
MITOTIC TELOPHASE CYTOKINESIS 13 3.73e-01 5.98e-01 0.22300 -2.19e-01 -0.041500 1.72e-01 7.96e-01
TIGHT JUNCTION INTERACTIONS 17 3.34e-01 5.64e-01 0.22200 -2.07e-01 -0.080600 1.39e-01 5.65e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.69e-01 3.76e-01 0.22200 2.20e-01 -0.030800 1.06e-01 8.21e-01
SELECTIVE AUTOPHAGY 72 4.69e-03 3.08e-02 0.22100 2.17e-01 0.042100 1.43e-03 5.37e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 2.18e-01 4.39e-01 0.22100 -2.17e-01 0.043600 1.46e-01 7.70e-01
REGULATION OF BETA CELL DEVELOPMENT 28 1.96e-01 4.08e-01 0.22100 -1.04e-01 -0.195000 3.43e-01 7.38e-02
PRC2 METHYLATES HISTONES AND DNA 30 1.37e-01 3.29e-01 0.22100 7.00e-02 0.210000 5.07e-01 4.69e-02
TCR SIGNALING 100 2.13e-03 1.65e-02 0.22000 8.46e-02 0.203000 1.44e-01 4.52e-04
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 2.72e-01 5.06e-01 0.22000 1.69e-01 0.140000 1.43e-01 2.25e-01
RNA POLYMERASE I PROMOTER ESCAPE 48 3.74e-02 1.45e-01 0.21900 5.70e-02 0.212000 4.95e-01 1.12e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 4.67e-01 6.81e-01 0.21900 -1.97e-01 -0.095600 2.19e-01 5.51e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 2.41e-01 4.72e-01 0.21900 2.11e-01 0.059700 9.47e-02 6.36e-01
RNA POLYMERASE I TRANSCRIPTION 68 2.11e-02 9.67e-02 0.21900 1.03e-01 0.193000 1.43e-01 5.91e-03
RUNX3 REGULATES NOTCH SIGNALING 13 4.94e-01 7.03e-01 0.21900 -1.85e-01 -0.117000 2.49e-01 4.65e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 2.04e-01 4.18e-01 0.21800 1.24e-01 0.180000 2.39e-01 8.86e-02
CD28 DEPENDENT VAV1 PATHWAY 11 2.72e-01 5.06e-01 0.21800 -1.31e-01 0.174000 4.54e-01 3.17e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 1.71e-01 3.78e-01 0.21700 -8.12e-02 -0.202000 4.49e-01 6.01e-02
ASSEMBLY OF THE HIV VIRION 16 4.36e-01 6.60e-01 0.21700 1.75e-01 0.128000 2.25e-01 3.74e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 1.19e-04 1.63e-03 0.21700 2.12e-01 -0.048200 4.84e-04 4.27e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 2.27e-01 4.49e-01 0.21700 1.34e-01 0.171000 2.12e-01 1.12e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 5.35e-01 7.30e-01 0.21700 1.78e-01 0.125000 2.87e-01 4.54e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 1.76e-01 3.86e-01 0.21700 -1.18e-01 0.182000 4.29e-01 2.23e-01
LAGGING STRAND SYNTHESIS 20 3.66e-01 5.92e-01 0.21700 1.61e-01 0.145000 2.12e-01 2.62e-01
OTHER SEMAPHORIN INTERACTIONS 19 3.81e-01 6.06e-01 0.21700 -1.69e-01 -0.135000 2.02e-01 3.07e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 3.38e-01 5.67e-01 0.21700 1.27e-01 0.175000 3.13e-01 1.65e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.20e-03 1.06e-02 0.21700 7.24e-03 -0.216000 9.12e-01 9.53e-04
BETA CATENIN INDEPENDENT WNT SIGNALING 138 2.41e-04 2.92e-03 0.21600 7.85e-02 0.201000 1.12e-01 4.48e-05
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 2.21e-01 4.41e-01 0.21600 -1.97e-01 -0.088000 8.24e-02 4.38e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.66e-01 6.81e-01 0.21500 2.05e-01 0.065100 2.19e-01 6.96e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 61 6.50e-03 3.96e-02 0.21500 1.21e-04 -0.215000 9.99e-01 3.76e-03
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 5.17e-01 7.21e-01 0.21400 -1.23e-01 -0.175000 4.43e-01 2.75e-01
DISEASES OF DNA REPAIR 11 2.81e-01 5.16e-01 0.21400 1.43e-01 -0.159000 4.13e-01 3.61e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 9.57e-02 2.60e-01 0.21400 1.11e-01 -0.182000 3.77e-01 1.48e-01
SCAVENGING BY CLASS A RECEPTORS 14 5.10e-01 7.16e-01 0.21200 1.42e-01 0.158000 3.58e-01 3.06e-01
HS GAG BIOSYNTHESIS 29 1.84e-01 3.92e-01 0.21200 1.98e-01 0.077200 6.56e-02 4.72e-01
INTERLEUKIN 1 FAMILY SIGNALING 121 2.14e-03 1.65e-02 0.21200 1.13e-01 0.180000 3.23e-02 6.53e-04
P75NTR SIGNALS VIA NF KB 16 4.65e-01 6.81e-01 0.21200 1.58e-01 0.141000 2.75e-01 3.28e-01
TRNA PROCESSING IN THE NUCLEUS 56 4.02e-02 1.50e-01 0.21100 -7.88e-02 -0.196000 3.08e-01 1.12e-02
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 3.19e-01 5.45e-01 0.21100 -8.41e-02 0.194000 6.29e-01 2.66e-01
INTERLEUKIN 12 SIGNALING 37 6.46e-02 2.05e-01 0.21100 1.86e-02 0.210000 8.44e-01 2.71e-02
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 3.58e-01 5.83e-01 0.21100 1.71e-01 0.123000 1.75e-01 3.30e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 3.39e-01 5.67e-01 0.21100 2.08e-01 -0.034800 2.13e-01 8.35e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 20 1.43e-01 3.37e-01 0.21100 -2.02e-01 0.059400 1.18e-01 6.46e-01
G PROTEIN BETA GAMMA SIGNALLING 30 3.50e-02 1.38e-01 0.21000 -1.50e-01 0.148000 1.56e-01 1.61e-01
C TYPE LECTIN RECEPTORS CLRS 111 1.25e-03 1.11e-02 0.20900 6.17e-02 0.200000 2.62e-01 2.78e-04
PECAM1 INTERACTIONS 12 2.68e-01 5.04e-01 0.20900 -1.60e-01 0.134000 3.36e-01 4.22e-01
BIOTIN TRANSPORT AND METABOLISM 11 5.88e-01 7.59e-01 0.20800 1.71e-01 0.119000 3.25e-01 4.95e-01
DERMATAN SULFATE BIOSYNTHESIS 11 4.91e-01 7.01e-01 0.20800 4.38e-02 0.203000 8.02e-01 2.43e-01
HIV ELONGATION ARREST AND RECOVERY 32 9.55e-02 2.60e-01 0.20800 2.07e-01 0.013300 4.25e-02 8.97e-01
MUCOPOLYSACCHARIDOSES 11 5.73e-01 7.54e-01 0.20700 1.81e-01 0.101000 2.98e-01 5.63e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 4.67e-01 6.81e-01 0.20700 3.80e-03 0.207000 9.83e-01 2.56e-01
SYNTHESIS OF PE 13 5.24e-01 7.26e-01 0.20700 1.79e-01 0.105000 2.65e-01 5.12e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 3.74e-01 5.98e-01 0.20700 -1.85e-01 -0.092600 1.63e-01 4.85e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 2.32e-04 2.85e-03 0.20700 7.85e-02 -0.191000 2.11e-01 2.30e-03
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 14 5.28e-01 7.26e-01 0.20700 1.53e-01 0.139000 3.22e-01 3.68e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 5.65e-01 7.52e-01 0.20600 -1.95e-01 -0.067000 2.87e-01 7.14e-01
THE PHOTOTRANSDUCTION CASCADE 21 3.44e-01 5.68e-01 0.20500 -1.83e-01 -0.091800 1.46e-01 4.66e-01
RAB GERANYLGERANYLATION 57 5.05e-02 1.75e-01 0.20500 -1.87e-01 -0.084100 1.46e-02 2.72e-01
KINESINS 47 1.42e-02 7.36e-02 0.20500 1.98e-01 -0.053300 1.91e-02 5.27e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 5.50e-01 7.43e-01 0.20400 1.21e-01 0.165000 4.52e-01 3.03e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 3.65e-01 5.91e-01 0.20400 5.43e-02 0.197000 6.98e-01 1.60e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 4.05e-01 6.26e-01 0.20300 -1.63e-01 -0.122000 2.08e-01 3.46e-01
DNA REPLICATION 121 4.30e-03 2.86e-02 0.20300 1.19e-01 0.164000 2.36e-02 1.83e-03
INTERFERON SIGNALING 164 1.52e-05 2.93e-04 0.20300 -2.02e-01 -0.019400 8.26e-06 6.69e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 4.54e-01 6.77e-01 0.20300 6.45e-03 0.203000 9.70e-01 2.45e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 240 2.23e-05 4.03e-04 0.20200 -1.18e-01 -0.164000 1.64e-03 1.19e-05
FOXO MEDIATED TRANSCRIPTION 58 2.60e-03 1.95e-02 0.20200 -1.54e-01 0.131000 4.21e-02 8.57e-02
RHOH GTPASE CYCLE 37 5.05e-02 1.75e-01 0.20200 -2.65e-02 0.200000 7.80e-01 3.54e-02
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 2.22e-01 4.42e-01 0.20100 1.83e-01 0.084400 8.32e-02 4.24e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 2.04e-03 1.62e-02 0.20100 -1.87e-01 0.073200 8.03e-03 3.00e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 2.05e-02 9.44e-02 0.20100 1.41e-01 0.143000 2.06e-02 1.82e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 3.49e-01 5.72e-01 0.20000 1.21e-01 0.160000 3.05e-01 1.75e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 2.13e-01 4.34e-01 0.20000 -1.89e-01 -0.067700 7.89e-02 5.28e-01
SIGNALING BY CSF3 G CSF 29 1.38e-01 3.29e-01 0.20000 1.28e-02 0.200000 9.05e-01 6.24e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 2.03e-01 4.16e-01 0.20000 1.19e-01 -0.161000 4.11e-01 2.65e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 3.97e-01 6.20e-01 0.19900 1.79e-01 0.086800 1.76e-01 5.12e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 3.14e-01 5.43e-01 0.19800 -1.06e-01 0.168000 5.26e-01 3.14e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 4.40e-04 4.88e-03 0.19800 -1.14e-01 -0.162000 8.73e-03 1.82e-04
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 1.04e-01 2.74e-01 0.19800 -1.32e-03 0.198000 9.90e-01 5.25e-02
MYOGENESIS 25 2.81e-01 5.16e-01 0.19800 -1.84e-01 -0.072200 1.11e-01 5.32e-01
RHOU GTPASE CYCLE 33 2.53e-01 4.90e-01 0.19800 -1.38e-01 -0.142000 1.71e-01 1.58e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 2.02e-01 4.16e-01 0.19800 1.18e-02 0.197000 9.20e-01 9.46e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 5.41e-02 1.84e-01 0.19600 -1.89e-01 -0.054800 1.66e-02 4.86e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 2.26e-01 4.47e-01 0.19600 -1.49e-01 -0.128000 1.23e-01 1.84e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 1.88e-01 3.97e-01 0.19600 3.35e-02 0.193000 7.59e-01 7.66e-02
SIGNALING BY FGFR2 IIIA TM 19 4.59e-01 6.77e-01 0.19600 1.34e-01 0.143000 3.11e-01 2.82e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 4.05e-03 2.72e-02 0.19600 1.95e-01 0.016100 1.76e-03 7.96e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 3.85e-03 2.61e-02 0.19600 6.31e-02 0.185000 2.58e-01 8.83e-04
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 1.54e-01 3.53e-01 0.19600 1.95e-01 0.006250 7.35e-02 9.54e-01
COLLAGEN FORMATION 79 1.71e-03 1.41e-02 0.19500 1.90e-01 -0.044500 3.49e-03 4.94e-01
OPIOID SIGNALLING 86 1.14e-02 6.24e-02 0.19500 -1.86e-01 -0.059500 2.89e-03 3.41e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 8.00e-02 2.34e-01 0.19500 1.80e-01 0.074300 2.46e-02 3.54e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 1.39e-01 3.29e-01 0.19500 1.12e-01 0.160000 1.85e-01 5.84e-02
SIGNALING BY VEGF 103 7.15e-03 4.29e-02 0.19400 -1.79e-01 -0.075200 1.67e-03 1.88e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 3.20e-01 5.47e-01 0.19400 -2.86e-02 0.192000 8.48e-01 1.97e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 3.41e-01 5.68e-01 0.19400 -1.75e-01 0.085000 2.95e-01 6.10e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 3.09e-01 5.40e-01 0.19400 1.71e-01 -0.092100 2.87e-01 5.65e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 33 2.67e-01 5.04e-01 0.19400 1.32e-01 0.142000 1.89e-01 1.59e-01
CHAPERONE MEDIATED AUTOPHAGY 21 3.64e-01 5.90e-01 0.19400 1.79e-01 0.073300 1.55e-01 5.61e-01
GLYCOSAMINOGLYCAN METABOLISM 114 8.43e-03 4.90e-02 0.19400 1.62e-01 0.107000 2.90e-03 4.91e-02
ERYTHROPOIETIN ACTIVATES RAS 13 2.92e-01 5.26e-01 0.19400 -1.34e-01 0.139000 4.02e-01 3.84e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.33e-01 3.23e-01 0.19300 -1.89e-01 0.038000 9.45e-02 7.37e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 4.60e-01 6.77e-01 0.19300 1.89e-01 0.041400 2.22e-01 7.89e-01
SIGNALING BY ERYTHROPOIETIN 24 2.92e-01 5.26e-01 0.19300 -1.84e-01 -0.057500 1.19e-01 6.26e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 6.12e-01 7.74e-01 0.19300 1.14e-01 0.156000 4.95e-01 3.50e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 2.70e-01 5.05e-01 0.19200 1.37e-01 -0.135000 3.73e-01 3.83e-01
MUSCLE CONTRACTION 162 1.66e-03 1.38e-02 0.19200 -1.49e-01 -0.121000 1.05e-03 8.12e-03
SHC1 EVENTS IN ERBB4 SIGNALING 13 3.10e-01 5.42e-01 0.19200 -1.65e-01 0.098900 3.04e-01 5.37e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 2.62e-03 1.95e-02 0.19100 1.72e-02 -0.190000 7.85e-01 2.46e-03
G1 S SPECIFIC TRANSCRIPTION 26 3.11e-01 5.43e-01 0.19000 8.00e-02 0.173000 4.80e-01 1.27e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 3.67e-01 5.92e-01 0.19000 1.64e-01 0.096800 1.65e-01 4.12e-01
COLLAGEN DEGRADATION 51 1.99e-02 9.23e-02 0.19000 4.42e-02 -0.185000 5.85e-01 2.23e-02
REGULATION OF IFNA SIGNALING 12 5.57e-01 7.49e-01 0.19000 1.80e-01 0.060700 2.81e-01 7.16e-01
REPRESSION OF WNT TARGET GENES 14 5.75e-01 7.54e-01 0.19000 1.13e-01 0.153000 4.65e-01 3.23e-01
LDL CLEARANCE 16 3.06e-01 5.37e-01 0.18900 1.86e-01 -0.034900 1.97e-01 8.09e-01
POLO LIKE KINASE MEDIATED EVENTS 14 5.87e-01 7.59e-01 0.18900 1.32e-01 0.135000 3.92e-01 3.81e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 6.03e-01 7.67e-01 0.18900 5.08e-02 0.182000 7.81e-01 3.19e-01
REGULATION OF IFNG SIGNALING 13 6.09e-01 7.72e-01 0.18800 1.20e-01 0.145000 4.55e-01 3.65e-01
ACYL CHAIN REMODELLING OF PG 10 4.78e-01 6.89e-01 0.18800 -3.88e-02 0.184000 8.32e-01 3.14e-01
THE NLRP3 INFLAMMASOME 15 4.92e-01 7.02e-01 0.18700 1.77e-01 0.060300 2.35e-01 6.86e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.25e-02 1.58e-01 0.18700 -1.28e-01 -0.136000 4.07e-02 3.03e-02
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 1.25e-02 6.72e-02 0.18700 -1.84e-01 -0.033400 4.06e-03 6.02e-01
NEUTROPHIL DEGRANULATION 385 2.71e-08 1.28e-06 0.18700 6.36e-02 0.175000 3.25e-02 3.72e-09
FRS MEDIATED FGFR4 SIGNALING 14 4.79e-01 6.89e-01 0.18700 3.73e-02 0.183000 8.09e-01 2.36e-01
TNF SIGNALING 43 1.99e-01 4.12e-01 0.18600 1.15e-01 0.147000 1.94e-01 9.62e-02
AMYLOID FIBER FORMATION 59 7.84e-02 2.33e-01 0.18500 7.38e-02 0.170000 3.27e-01 2.41e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.74e-01 3.82e-01 0.18500 1.25e-01 0.136000 1.34e-01 1.02e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 3.91e-01 6.13e-01 0.18500 6.76e-02 -0.172000 6.85e-01 3.02e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 45 8.07e-02 2.35e-01 0.18300 1.60e-02 0.183000 8.52e-01 3.42e-02
PRE NOTCH PROCESSING IN GOLGI 17 5.44e-01 7.38e-01 0.18300 1.35e-01 0.123000 3.34e-01 3.78e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 2.68e-01 5.04e-01 0.18300 9.07e-04 0.183000 9.94e-01 1.37e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 63 8.43e-02 2.40e-01 0.18300 8.88e-02 0.160000 2.23e-01 2.81e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.93e-01 7.61e-01 0.18300 -8.31e-02 -0.163000 6.04e-01 3.09e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 23 3.15e-01 5.43e-01 0.18300 1.79e-01 0.037300 1.37e-01 7.57e-01
EPHRIN SIGNALING 19 2.02e-01 4.16e-01 0.18200 1.31e-01 -0.127000 3.21e-01 3.40e-01
INWARDLY RECTIFYING K CHANNELS 31 2.79e-01 5.15e-01 0.18200 -1.65e-01 -0.076900 1.11e-01 4.59e-01
PLASMA LIPOPROTEIN REMODELING 17 2.71e-01 5.06e-01 0.18200 6.88e-02 -0.169000 6.23e-01 2.28e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 48 1.08e-01 2.80e-01 0.18200 5.12e-02 0.175000 5.39e-01 3.65e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 3.19e-01 5.45e-01 0.18200 6.16e-02 0.171000 5.87e-01 1.31e-01
ERKS ARE INACTIVATED 13 5.57e-01 7.49e-01 0.18100 -5.61e-02 -0.173000 7.26e-01 2.81e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 36 2.79e-01 5.15e-01 0.18100 1.42e-01 0.113000 1.42e-01 2.42e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 5.43e-01 7.37e-01 0.18100 1.65e-01 0.073800 2.69e-01 6.21e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 1.35e-01 3.26e-01 0.18000 -1.80e-01 0.008960 7.35e-02 9.29e-01
SHC MEDIATED CASCADE FGFR4 12 5.27e-01 7.26e-01 0.18000 1.74e-02 0.179000 9.17e-01 2.84e-01
ENOS ACTIVATION 11 4.54e-01 6.77e-01 0.18000 -1.71e-01 0.055400 3.27e-01 7.50e-01
RHOBTB1 GTPASE CYCLE 23 1.65e-01 3.68e-01 0.17900 -1.52e-01 0.094900 2.08e-01 4.31e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 4.13e-01 6.35e-01 0.17900 -1.12e-01 0.139000 5.18e-01 4.25e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 2.59e-02 1.10e-01 0.17900 -5.82e-02 0.169000 4.72e-01 3.68e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 3.73e-01 5.98e-01 0.17900 1.60e-01 -0.079400 3.18e-01 6.20e-01
FORMATION OF THE CORNIFIED ENVELOPE 30 1.13e-01 2.89e-01 0.17900 1.67e-01 -0.063100 1.13e-01 5.50e-01
KERATINIZATION 30 1.13e-01 2.89e-01 0.17900 1.67e-01 -0.063100 1.13e-01 5.50e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 7.55e-02 2.26e-01 0.17800 1.64e-01 -0.069400 9.23e-02 4.78e-01
SIGNALING BY NTRK2 TRKB 24 3.43e-01 5.68e-01 0.17800 -1.71e-01 -0.050200 1.47e-01 6.70e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 3.71e-01 5.97e-01 0.17800 1.74e-01 -0.035800 2.42e-01 8.10e-01
CARNITINE METABOLISM 14 5.43e-01 7.37e-01 0.17800 1.70e-01 0.053400 2.71e-01 7.29e-01
TELOMERE MAINTENANCE 79 6.99e-02 2.16e-01 0.17800 1.21e-01 0.131000 6.36e-02 4.47e-02
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 1.02e-01 2.71e-01 0.17800 -7.70e-02 -0.160000 3.06e-01 3.31e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 1.60e-02 7.99e-02 0.17800 1.14e-01 -0.136000 1.55e-01 8.88e-02
HYALURONAN METABOLISM 15 5.83e-01 7.58e-01 0.17800 9.37e-02 0.151000 5.30e-01 3.12e-01
SLC TRANSPORTER DISORDERS 76 7.37e-02 2.23e-01 0.17800 -1.07e-01 -0.142000 1.07e-01 3.28e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 4.56e-01 6.77e-01 0.17700 1.04e-01 -0.144000 5.70e-01 4.31e-01
AUTOPHAGY 139 1.78e-03 1.44e-02 0.17700 1.72e-01 0.041600 4.62e-04 3.98e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.61e-01 6.77e-01 0.17700 -1.73e-01 0.033800 2.99e-01 8.39e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 3.81e-01 6.06e-01 0.17600 -4.82e-02 -0.170000 6.96e-01 1.69e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 1.31e-01 3.20e-01 0.17600 -7.26e-02 0.160000 5.06e-01 1.42e-01
TELOMERE EXTENSION BY TELOMERASE 22 4.83e-01 6.91e-01 0.17600 1.15e-01 0.133000 3.51e-01 2.81e-01
ANCHORING FIBRIL FORMATION 14 4.10e-01 6.31e-01 0.17500 3.40e-02 -0.172000 8.26e-01 2.65e-01
SIGNALING BY NTRKS 130 3.72e-03 2.59e-02 0.17500 -4.82e-02 -0.169000 3.43e-01 9.15e-04
FORMATION OF THE EARLY ELONGATION COMPLEX 33 2.73e-01 5.06e-01 0.17500 1.62e-01 0.066500 1.07e-01 5.08e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 16 3.91e-01 6.13e-01 0.17500 -1.75e-01 0.013700 2.26e-01 9.24e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 5.70e-01 7.54e-01 0.17500 -1.49e-01 -0.091800 3.01e-01 5.25e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 4.24e-01 6.48e-01 0.17500 1.75e-01 -0.008330 2.41e-01 9.55e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 3.26e-01 5.53e-01 0.17500 1.49e-01 -0.091400 3.18e-01 5.40e-01
DAP12 SIGNALING 24 1.82e-01 3.91e-01 0.17400 -1.60e-01 0.069600 1.75e-01 5.55e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.82e-01 7.58e-01 0.17400 -1.74e-01 -0.001580 3.41e-01 9.93e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 603 1.41e-09 7.51e-08 0.17400 8.75e-02 0.150000 2.55e-04 3.64e-10
IRAK1 RECRUITS IKK COMPLEX 14 6.04e-01 7.68e-01 0.17400 8.08e-02 0.154000 6.01e-01 3.20e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 3.23e-01 5.50e-01 0.17300 1.11e-01 0.133000 2.54e-01 1.74e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 4.79e-01 6.89e-01 0.17300 -1.17e-01 -0.127000 3.30e-01 2.91e-01
PHOSPHORYLATION OF THE APC C 17 5.64e-01 7.52e-01 0.17300 1.44e-01 0.095300 3.03e-01 4.96e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 4.71e-03 3.08e-02 0.17300 6.49e-02 0.160000 1.85e-01 1.06e-03
SIGNALING BY THE B CELL RECEPTOR BCR 104 1.70e-02 8.30e-02 0.17300 6.03e-02 0.162000 2.88e-01 4.32e-03
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 1.44e-03 1.23e-02 0.17300 6.34e-02 -0.161000 2.83e-01 6.56e-03
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 106 1.54e-02 7.76e-02 0.17200 5.84e-02 0.162000 2.99e-01 3.91e-03
FGFR2 MUTANT RECEPTOR ACTIVATION 26 4.39e-01 6.62e-01 0.17200 1.27e-01 0.116000 2.61e-01 3.07e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 1.50e-01 3.46e-01 0.17200 1.05e-01 0.136000 1.61e-01 7.08e-02
PYRIMIDINE CATABOLISM 10 6.29e-01 7.86e-01 0.17200 2.70e-02 0.170000 8.82e-01 3.53e-01
SPHINGOLIPID METABOLISM 80 2.16e-02 9.81e-02 0.17200 1.96e-02 0.171000 7.62e-01 8.35e-03
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 1.84e-01 3.92e-01 0.17200 -1.25e-01 -0.118000 1.12e-01 1.35e-01
PLATELET HOMEOSTASIS 77 4.44e-02 1.62e-01 0.17100 -1.64e-01 -0.050200 1.31e-02 4.46e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 66 8.56e-02 2.44e-01 0.17100 6.54e-02 0.158000 3.58e-01 2.66e-02
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 33 1.61e-01 3.62e-01 0.17100 -1.24e-02 0.170000 9.02e-01 9.07e-02
MITOPHAGY 29 3.98e-01 6.20e-01 0.17000 1.01e-01 0.137000 3.44e-01 2.03e-01
METABOLISM OF NUCLEOTIDES 92 5.71e-02 1.91e-01 0.17000 1.07e-01 0.132000 7.68e-02 2.84e-02
PEPTIDE LIGAND BINDING RECEPTORS 117 2.32e-02 1.01e-01 0.17000 1.41e-01 0.094700 8.36e-03 7.72e-02
RECEPTOR MEDIATED MITOPHAGY 11 6.60e-01 8.08e-01 0.17000 -6.09e-02 -0.159000 7.27e-01 3.63e-01
PROTEIN UBIQUITINATION 70 1.22e-02 6.63e-02 0.17000 -4.72e-02 0.163000 4.95e-01 1.83e-02
SIGNALING BY FGFR2 63 1.17e-01 2.96e-01 0.16900 7.96e-02 0.150000 2.75e-01 4.01e-02
REGULATION OF KIT SIGNALING 16 5.47e-01 7.41e-01 0.16900 -5.99e-02 -0.158000 6.78e-01 2.73e-01
MITOTIC PROPHASE 95 3.58e-02 1.40e-01 0.16900 -7.26e-02 -0.153000 2.21e-01 1.01e-02
DISEASES OF GLYCOSYLATION 123 1.19e-02 6.45e-02 0.16900 1.56e-01 0.065700 2.90e-03 2.08e-01
METABOLISM OF FOLATE AND PTERINES 15 5.75e-01 7.54e-01 0.16900 1.57e-01 0.062000 2.93e-01 6.78e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 6.67e-01 8.10e-01 0.16900 1.00e-01 0.135000 5.31e-01 3.98e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 1.35e-01 3.26e-01 0.16800 -8.49e-03 0.168000 9.28e-01 7.35e-02
PYRUVATE METABOLISM 27 3.50e-01 5.73e-01 0.16800 -1.60e-01 -0.049800 1.50e-01 6.54e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 1.51e-01 3.47e-01 0.16800 -1.54e-01 0.065500 1.50e-01 5.42e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 5.86e-01 7.58e-01 0.16700 -1.17e-01 -0.119000 3.89e-01 3.82e-01
RHOV GTPASE CYCLE 32 3.85e-01 6.10e-01 0.16600 -1.04e-01 -0.130000 3.09e-01 2.05e-01
CITRIC ACID CYCLE TCA CYCLE 22 4.30e-01 6.53e-01 0.16600 1.59e-01 0.048400 1.97e-01 6.94e-01
CILIUM ASSEMBLY 191 1.40e-05 2.74e-04 0.16600 1.61e-01 -0.040900 1.29e-04 3.30e-01
RAC3 GTPASE CYCLE 89 5.35e-03 3.38e-02 0.16500 -1.60e-01 0.042000 9.09e-03 4.94e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 3.89e-01 6.13e-01 0.16500 -1.28e-01 -0.105000 2.10e-01 3.05e-01
NRAGE SIGNALS DEATH THROUGH JNK 55 1.36e-01 3.28e-01 0.16500 -5.60e-02 -0.155000 4.73e-01 4.62e-02
CD209 DC SIGN SIGNALING 18 3.71e-01 5.97e-01 0.16500 -1.63e-01 0.026500 2.32e-01 8.46e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 5.94e-01 7.61e-01 0.16400 -1.60e-01 -0.034900 3.18e-01 8.28e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 1.86e-01 3.94e-01 0.16400 -5.80e-02 -0.153000 4.87e-01 6.66e-02
RND1 GTPASE CYCLE 38 3.16e-01 5.43e-01 0.16400 -8.82e-02 -0.138000 3.47e-01 1.42e-01
FRS MEDIATED FGFR3 SIGNALING 15 5.35e-01 7.30e-01 0.16400 2.71e-02 0.161000 8.56e-01 2.79e-01
RAC2 GTPASE CYCLE 87 1.19e-02 6.45e-02 0.16400 -1.63e-01 0.013000 8.58e-03 8.34e-01
INTERLEUKIN 17 SIGNALING 67 1.03e-01 2.72e-01 0.16300 -6.30e-02 -0.151000 3.73e-01 3.30e-02
FGFR2 LIGAND BINDING AND ACTIVATION 12 6.52e-01 8.01e-01 0.16300 5.42e-02 0.154000 7.45e-01 3.56e-01
PROCESSING OF SMDT1 16 6.18e-01 7.79e-01 0.16300 1.37e-01 0.088200 3.43e-01 5.42e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.95e-01 4.06e-01 0.16300 1.49e-01 0.064900 7.06e-02 4.32e-01
FANCONI ANEMIA PATHWAY 36 1.41e-01 3.32e-01 0.16300 1.60e-01 -0.030200 9.71e-02 7.54e-01
NEUREXINS AND NEUROLIGINS 54 1.28e-01 3.15e-01 0.16300 -1.57e-01 -0.040500 4.55e-02 6.07e-01
RHO GTPASES ACTIVATE KTN1 11 5.64e-01 7.52e-01 0.16200 -2.02e-02 0.161000 9.08e-01 3.55e-01
METABOLISM OF RNA 644 2.64e-08 1.28e-06 0.16200 1.09e-01 0.120000 2.41e-06 2.36e-07
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 4.35e-01 6.59e-01 0.16200 -1.46e-01 -0.071000 1.98e-01 5.31e-01
SNRNP ASSEMBLY 51 1.28e-01 3.15e-01 0.16100 -2.73e-02 -0.159000 7.36e-01 4.97e-02
RND2 GTPASE CYCLE 38 2.85e-01 5.19e-01 0.16100 -6.20e-02 -0.148000 5.09e-01 1.13e-01
TRIGLYCERIDE CATABOLISM 14 4.12e-01 6.33e-01 0.16000 -8.69e-02 0.135000 5.73e-01 3.82e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 6.53e-01 8.01e-01 0.16000 1.60e-01 0.015400 3.82e-01 9.33e-01
METABOLISM OF COFACTORS 19 5.85e-01 7.58e-01 0.16000 9.50e-02 0.129000 4.74e-01 3.30e-01
DNA DAMAGE RECOGNITION IN GG NER 38 9.49e-02 2.60e-01 0.16000 1.38e-01 -0.081000 1.42e-01 3.88e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.81e-01 3.90e-01 0.16000 -9.20e-02 0.130000 4.08e-01 2.41e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 5.92e-01 7.61e-01 0.15900 9.68e-02 0.126000 4.65e-01 3.41e-01
S PHASE 153 6.10e-03 3.79e-02 0.15800 5.16e-02 0.149000 2.71e-01 1.44e-03
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 1.59e-01 3.60e-01 0.15800 1.21e-01 0.101000 8.28e-02 1.46e-01
RHOBTB GTPASE CYCLE 35 1.11e-01 2.87e-01 0.15800 -1.09e-01 0.113000 2.63e-01 2.45e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 2.75e-02 1.15e-01 0.15700 1.48e-01 -0.054500 4.11e-02 4.51e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 5.79e-01 7.56e-01 0.15700 2.26e-02 0.155000 8.83e-01 3.14e-01
INTERLEUKIN 12 FAMILY SIGNALING 44 1.24e-01 3.10e-01 0.15700 -1.43e-02 0.156000 8.70e-01 7.30e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 9.46e-02 2.60e-01 0.15500 -7.38e-02 -0.137000 2.45e-01 3.16e-02
GOLGI TO ER RETROGRADE TRANSPORT 119 4.53e-03 2.99e-02 0.15500 1.55e-01 -0.010600 3.57e-03 8.41e-01
CHROMOSOME MAINTENANCE 102 4.39e-02 1.61e-01 0.15500 5.82e-02 0.143000 3.10e-01 1.24e-02
SHC MEDIATED CASCADE FGFR3 13 5.85e-01 7.58e-01 0.15500 7.09e-03 0.154000 9.65e-01 3.35e-01
IRS MEDIATED SIGNALLING 39 3.73e-01 5.98e-01 0.15400 -1.16e-01 -0.101000 2.10e-01 2.75e-01
RAC1 GTPASE CYCLE 177 3.83e-03 2.61e-02 0.15400 -1.45e-01 -0.050300 8.72e-04 2.49e-01
INTERLEUKIN 35 SIGNALLING 10 7.38e-01 8.53e-01 0.15400 -5.77e-02 -0.142000 7.52e-01 4.36e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 2.21e-01 4.41e-01 0.15300 -1.37e-01 0.068900 2.18e-01 5.35e-01
PI 3K CASCADE FGFR2 16 5.28e-01 7.26e-01 0.15300 -1.53e-01 -0.008940 2.91e-01 9.51e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.38e-01 6.62e-01 0.15300 1.06e-01 -0.110000 4.92e-01 4.77e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 3.74e-01 5.98e-01 0.15200 -5.76e-02 -0.141000 5.67e-01 1.61e-01
BILE ACID AND BILE SALT METABOLISM 24 3.04e-01 5.36e-01 0.15100 -3.96e-02 0.146000 7.37e-01 2.15e-01
METABOLISM OF CARBOHYDRATES 258 2.64e-05 4.70e-04 0.15100 1.51e-01 -0.001210 2.92e-05 9.73e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 5.90e-01 7.61e-01 0.15100 1.38e-01 -0.059300 4.49e-01 7.45e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 6.95e-01 8.28e-01 0.15000 -1.46e-01 -0.035800 4.01e-01 8.37e-01
SEPARATION OF SISTER CHROMATIDS 166 1.45e-02 7.49e-02 0.15000 1.27e-01 0.080100 4.71e-03 7.53e-02
NUCLEAR SIGNALING BY ERBB4 31 4.23e-01 6.46e-01 0.15000 6.38e-02 0.136000 5.39e-01 1.91e-01
RHO GTPASES ACTIVATE PAKS 21 3.03e-01 5.36e-01 0.15000 -1.00e-01 0.112000 4.26e-01 3.76e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 5.70e-01 7.54e-01 0.15000 1.47e-01 -0.030700 3.79e-01 8.54e-01
NUCLEOBASE BIOSYNTHESIS 15 4.82e-01 6.91e-01 0.15000 3.98e-02 -0.144000 7.90e-01 3.33e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 3.06e-01 5.37e-01 0.14900 -1.71e-02 0.148000 8.78e-01 1.82e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 4.56e-01 6.77e-01 0.14900 1.43e-01 -0.043400 3.23e-01 7.64e-01
INSULIN RECEPTOR SIGNALLING CASCADE 44 3.44e-01 5.68e-01 0.14900 -1.19e-01 -0.090100 1.73e-01 3.01e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 178 1.31e-02 6.91e-02 0.14900 8.53e-02 0.122000 5.00e-02 5.03e-03
EXTENSION OF TELOMERES 49 3.16e-01 5.43e-01 0.14900 1.03e-01 0.108000 2.14e-01 1.93e-01
PROLACTIN RECEPTOR SIGNALING 11 6.40e-01 7.95e-01 0.14900 -4.30e-03 0.149000 9.80e-01 3.94e-01
SYNTHESIS OF PC 26 3.89e-01 6.13e-01 0.14900 1.51e-02 0.148000 8.94e-01 1.92e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 5.46e-01 7.39e-01 0.14800 -8.98e-02 0.118000 6.06e-01 4.98e-01
TRP CHANNELS 18 5.73e-01 7.54e-01 0.14800 -4.01e-02 -0.142000 7.68e-01 2.96e-01
SIALIC ACID METABOLISM 32 4.78e-01 6.89e-01 0.14700 -1.07e-01 -0.101000 2.94e-01 3.23e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 5.18e-01 7.22e-01 0.14700 -1.02e-01 0.106000 5.41e-01 5.24e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 3.76e-01 6.00e-01 0.14600 -1.46e-01 0.003010 2.05e-01 9.79e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 7.99e-02 2.34e-01 0.14600 -2.12e-02 -0.144000 7.51e-01 3.06e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 42 1.88e-01 3.97e-01 0.14600 1.46e-01 -0.007810 1.02e-01 9.30e-01
NGF STIMULATED TRANSCRIPTION 37 3.16e-01 5.43e-01 0.14600 -3.40e-02 -0.142000 7.21e-01 1.35e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 94 9.85e-02 2.65e-01 0.14600 -1.27e-01 -0.072500 3.41e-02 2.25e-01
INOSITOL PHOSPHATE METABOLISM 47 2.78e-01 5.14e-01 0.14600 -5.43e-02 -0.135000 5.20e-01 1.09e-01
SIGNALING BY EGFR IN CANCER 22 3.45e-01 5.68e-01 0.14600 -1.36e-01 0.052300 2.70e-01 6.71e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 1.32e-03 1.16e-02 0.14500 1.39e-01 -0.044500 4.41e-03 3.61e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 5.60e-01 7.50e-01 0.14500 -1.17e-01 0.085900 5.01e-01 6.22e-01
CRMPS IN SEMA3A SIGNALING 16 4.39e-01 6.62e-01 0.14500 7.43e-02 -0.125000 6.07e-01 3.87e-01
SIGNALING BY PDGF 57 8.01e-02 2.34e-01 0.14500 3.19e-02 -0.141000 6.77e-01 6.48e-02
PURINE SALVAGE 12 7.47e-01 8.58e-01 0.14500 1.25e-01 0.072100 4.52e-01 6.66e-01
SYNTHESIS OF PA 29 4.97e-01 7.04e-01 0.14400 1.25e-01 0.072200 2.45e-01 5.01e-01
FERTILIZATION 13 7.37e-01 8.52e-01 0.14400 -7.72e-02 -0.121000 6.30e-01 4.49e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.64e-01 3.68e-01 0.14300 3.02e-02 -0.140000 7.35e-01 1.16e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 4.61e-01 6.77e-01 0.14300 -1.36e-01 0.044200 3.31e-01 7.52e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 3.42e-01 5.68e-01 0.14300 -1.15e-01 0.085400 3.62e-01 4.98e-01
TBC RABGAPS 43 1.09e-01 2.80e-01 0.14300 1.02e-01 -0.100000 2.48e-01 2.55e-01
PTEN REGULATION 133 5.67e-02 1.90e-01 0.14300 1.01e-01 0.101000 4.42e-02 4.48e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX 107 6.85e-03 4.15e-02 0.14300 5.24e-02 -0.133000 3.49e-01 1.77e-02
EPIGENETIC REGULATION OF GENE EXPRESSION 104 5.28e-02 1.80e-01 0.14300 4.04e-02 0.137000 4.76e-01 1.61e-02
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 6.97e-01 8.28e-01 0.14200 -5.50e-02 -0.131000 7.22e-01 3.95e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 7.08e-01 8.33e-01 0.14200 9.31e-02 0.107000 5.19e-01 4.59e-01
MICRORNA MIRNA BIOGENESIS 24 5.13e-01 7.19e-01 0.14100 1.35e-01 0.041000 2.51e-01 7.28e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 3.12e-01 5.43e-01 0.14100 1.22e-01 -0.070800 2.99e-01 5.48e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 32 3.92e-01 6.13e-01 0.14100 1.37e-01 0.032300 1.79e-01 7.52e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 6.47e-01 7.98e-01 0.14100 7.28e-02 0.121000 5.83e-01 3.62e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 1.91e-01 4.01e-01 0.14100 -1.02e-01 0.097100 3.10e-01 3.35e-01
MITOTIC PROMETAPHASE 177 4.09e-03 2.73e-02 0.14000 -1.88e-02 -0.139000 6.66e-01 1.48e-03
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 4.64e-01 6.81e-01 0.14000 -3.88e-02 -0.134000 7.22e-01 2.19e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 7.66e-01 8.70e-01 0.13900 -1.19e-01 -0.072600 4.76e-01 6.63e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 1.49e-01 3.45e-01 0.13900 -1.32e-01 -0.042400 5.22e-02 5.34e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 5.21e-01 7.24e-01 0.13900 3.18e-02 0.135000 7.92e-01 2.62e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 3.37e-01 5.67e-01 0.13800 -1.36e-01 -0.019700 1.57e-01 8.38e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 25 5.14e-01 7.19e-01 0.13800 3.85e-02 0.132000 7.39e-01 2.52e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 5.34e-01 7.30e-01 0.13800 -5.33e-02 -0.127000 6.38e-01 2.63e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 17 5.13e-01 7.19e-01 0.13700 -1.34e-01 0.028300 3.38e-01 8.40e-01
ONCOGENE INDUCED SENESCENCE 32 4.55e-01 6.77e-01 0.13700 4.76e-02 0.128000 6.41e-01 2.10e-01
CIRCADIAN CLOCK 68 1.05e-01 2.75e-01 0.13600 -1.36e-01 0.000221 5.26e-02 9.97e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 6.83e-01 8.21e-01 0.13500 -1.35e-01 -0.005400 4.18e-01 9.74e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 1.69e-02 8.29e-02 0.13500 -9.35e-02 0.097400 1.27e-01 1.13e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 5.48e-01 7.41e-01 0.13500 -1.34e-01 0.013900 3.38e-01 9.21e-01
SUMOYLATION 164 4.28e-02 1.59e-01 0.13500 -1.01e-01 -0.088700 2.56e-02 5.02e-02
STIMULI SENSING CHANNELS 74 2.41e-01 4.72e-01 0.13400 -1.00e-01 -0.089600 1.37e-01 1.83e-01
BASE EXCISION REPAIR AP SITE FORMATION 30 3.58e-01 5.83e-01 0.13400 1.34e-01 -0.009860 2.05e-01 9.26e-01
PI 3K CASCADE FGFR4 12 6.30e-01 7.86e-01 0.13400 -1.30e-01 0.032900 4.36e-01 8.44e-01
SPRY REGULATION OF FGF SIGNALING 16 6.14e-01 7.76e-01 0.13400 1.34e-01 0.009050 3.55e-01 9.50e-01
GP1B IX V ACTIVATION SIGNALLING 10 7.66e-01 8.70e-01 0.13400 -2.83e-02 -0.131000 8.77e-01 4.74e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 22 6.53e-01 8.01e-01 0.13400 -1.05e-01 -0.082400 3.93e-01 5.04e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.32e-01 4.56e-01 0.13300 1.28e-01 0.037200 8.97e-02 6.21e-01
GPVI MEDIATED ACTIVATION CASCADE 31 2.52e-01 4.90e-01 0.13300 -9.54e-02 0.092100 3.58e-01 3.75e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 2.91e-01 5.26e-01 0.13200 6.84e-03 0.132000 9.40e-01 1.43e-01
RHO GTPASES ACTIVATE ROCKS 19 5.96e-01 7.63e-01 0.13200 2.05e-02 0.130000 8.77e-01 3.26e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 6.48e-02 2.05e-01 0.13100 -9.89e-02 0.086500 1.75e-01 2.35e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 5.29e-01 7.26e-01 0.13100 2.93e-02 0.128000 8.00e-01 2.68e-01
INFECTIOUS DISEASE 732 1.41e-07 5.87e-06 0.13100 4.72e-02 0.122000 3.04e-02 1.96e-08
SIGNALING BY ERBB2 48 1.55e-01 3.54e-01 0.13100 -1.23e-01 0.045100 1.41e-01 5.89e-01
G0 AND EARLY G1 24 5.04e-01 7.11e-01 0.13100 1.19e-02 0.130000 9.19e-01 2.69e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 4.43e-01 6.68e-01 0.13100 -8.12e-02 0.102000 5.40e-01 4.40e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 1.77e-01 3.87e-01 0.13100 -6.43e-02 0.114000 4.71e-01 2.02e-01
SIGNALING BY KIT IN DISEASE 20 6.77e-01 8.17e-01 0.13100 -1.11e-01 -0.068600 3.90e-01 5.96e-01
PI 3K CASCADE FGFR3 13 6.40e-01 7.95e-01 0.13000 -1.29e-01 0.019800 4.21e-01 9.02e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 4.90e-01 7.00e-01 0.13000 -6.97e-02 -0.110000 4.63e-01 2.46e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 1.50e-03 1.27e-02 0.12900 1.20e-01 -0.047100 6.62e-03 2.88e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 7.93e-01 8.86e-01 0.12900 -9.75e-02 -0.084700 5.43e-01 5.97e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 6.66e-01 8.10e-01 0.12900 -2.40e-02 -0.127000 8.68e-01 3.81e-01
RHOF GTPASE CYCLE 40 4.30e-01 6.53e-01 0.12900 -1.19e-01 -0.049700 1.94e-01 5.87e-01
VXPX CARGO TARGETING TO CILIUM 19 4.59e-01 6.77e-01 0.12900 1.07e-01 -0.071600 4.20e-01 5.89e-01
BASIGIN INTERACTIONS 22 6.49e-01 7.99e-01 0.12800 -5.94e-02 -0.114000 6.30e-01 3.56e-01
REPRODUCTION 76 2.65e-01 5.04e-01 0.12800 -9.55e-02 -0.085300 1.50e-01 1.99e-01
MITOTIC METAPHASE AND ANAPHASE 207 2.25e-02 9.99e-02 0.12800 1.08e-01 0.068200 7.49e-03 9.12e-02
CALNEXIN CALRETICULIN CYCLE 26 6.26e-01 7.84e-01 0.12800 7.37e-02 0.104000 5.16e-01 3.57e-01
HATS ACETYLATE HISTONES 93 6.45e-02 2.05e-01 0.12800 2.04e-03 -0.128000 9.73e-01 3.36e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 7.82e-01 8.78e-01 0.12700 8.05e-02 0.098700 6.02e-01 5.23e-01
REGULATION OF FZD BY UBIQUITINATION 20 6.53e-01 8.01e-01 0.12600 1.19e-01 0.041800 3.57e-01 7.46e-01
MEIOSIS 63 3.39e-01 5.67e-01 0.12600 -9.91e-02 -0.077700 1.74e-01 2.86e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 2.56e-01 4.92e-01 0.12600 -9.25e-02 0.085500 3.50e-01 3.89e-01
CELL JUNCTION ORGANIZATION 73 2.66e-01 5.04e-01 0.12600 -1.08e-01 -0.064900 1.11e-01 3.38e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.15e-01 7.19e-01 0.12600 3.74e-02 -0.120000 7.78e-01 3.65e-01
SIGNALING BY FGFR 74 2.00e-01 4.14e-01 0.12600 3.71e-02 0.120000 5.81e-01 7.45e-02
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 45 3.81e-01 6.06e-01 0.12500 -3.83e-02 -0.119000 6.57e-01 1.67e-01
SIGNALING BY ERBB4 57 1.07e-01 2.77e-01 0.12500 -8.97e-02 0.086800 2.42e-01 2.57e-01
RHOB GTPASE CYCLE 67 3.32e-01 5.60e-01 0.12500 -8.77e-02 -0.088400 2.14e-01 2.11e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 2.69e-01 5.05e-01 0.12400 -3.93e-02 0.118000 6.75e-01 2.08e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 52 1.81e-01 3.90e-01 0.12400 1.21e-01 -0.029200 1.32e-01 7.15e-01
RHOBTB2 GTPASE CYCLE 23 4.21e-01 6.45e-01 0.12400 -6.35e-02 0.107000 5.98e-01 3.76e-01
LYSOSOME VESICLE BIOGENESIS 32 2.93e-01 5.26e-01 0.12400 7.74e-02 -0.096500 4.49e-01 3.45e-01
GAP JUNCTION DEGRADATION 11 7.44e-01 8.58e-01 0.12400 3.18e-03 0.123000 9.85e-01 4.78e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 4.99e-01 7.06e-01 0.12300 -5.78e-02 0.109000 6.63e-01 4.10e-01
G2 M CHECKPOINTS 133 9.10e-02 2.52e-01 0.12300 5.77e-02 0.109000 2.51e-01 3.00e-02
KILLING MECHANISMS 10 8.00e-01 8.92e-01 0.12300 1.20e-01 0.026700 5.12e-01 8.84e-01
HCMV EARLY EVENTS 81 4.82e-02 1.69e-01 0.12200 7.66e-02 -0.095400 2.33e-01 1.38e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 1.55e-01 3.54e-01 0.12200 -4.10e-02 -0.115000 4.92e-01 5.39e-02
VITAMIN B5 PANTOTHENATE METABOLISM 15 7.48e-01 8.59e-01 0.12200 -4.48e-02 -0.114000 7.64e-01 4.46e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 6.44e-01 7.98e-01 0.12200 1.21e-01 -0.014100 4.16e-01 9.24e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 5.71e-01 7.54e-01 0.12200 1.25e-02 0.121000 9.18e-01 3.15e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 6.97e-01 8.28e-01 0.12100 -1.19e-01 -0.022600 4.09e-01 8.76e-01
SARS COV 2 INFECTION 65 3.46e-01 5.69e-01 0.12100 6.77e-02 0.100000 3.46e-01 1.62e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 178 3.87e-02 1.47e-01 0.12100 4.74e-02 0.111000 2.76e-01 1.08e-02
SIGNALLING TO ERKS 33 5.75e-01 7.54e-01 0.12000 -6.01e-02 -0.104000 5.50e-01 3.01e-01
COSTIMULATION BY THE CD28 FAMILY 50 2.55e-01 4.91e-01 0.12000 -1.20e-01 0.008310 1.43e-01 9.19e-01
MAP2K AND MAPK ACTIVATION 36 2.86e-01 5.19e-01 0.12000 -5.90e-02 0.104000 5.40e-01 2.78e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 22 5.92e-01 7.61e-01 0.12000 -1.19e-01 -0.011300 3.33e-01 9.27e-01
MHC CLASS II ANTIGEN PRESENTATION 102 4.48e-02 1.62e-01 0.12000 1.17e-01 -0.028100 4.21e-02 6.24e-01
GENE SILENCING BY RNA 83 1.71e-01 3.78e-01 0.12000 -2.51e-02 -0.117000 6.93e-01 6.58e-02
LAMININ INTERACTIONS 29 6.03e-01 7.67e-01 0.11900 -1.08e-01 -0.051900 3.16e-01 6.28e-01
EPHB MEDIATED FORWARD SIGNALING 42 2.60e-01 4.98e-01 0.11900 -1.11e-01 0.042200 2.14e-01 6.36e-01
MRNA SPLICING 188 5.08e-02 1.75e-01 0.11800 1.01e-01 0.062500 1.74e-02 1.40e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 1.23e-01 3.07e-01 0.11800 -1.16e-01 -0.019400 4.76e-02 7.42e-01
G ALPHA Z SIGNALLING EVENTS 45 2.06e-01 4.22e-01 0.11800 -8.37e-02 0.083100 3.32e-01 3.35e-01
APOPTOTIC EXECUTION PHASE 45 2.79e-01 5.15e-01 0.11700 -1.15e-01 0.021500 1.81e-01 8.03e-01
SYNDECAN INTERACTIONS 27 6.25e-01 7.84e-01 0.11700 4.55e-02 0.108000 6.82e-01 3.33e-01
VISUAL PHOTOTRANSDUCTION 62 4.02e-01 6.24e-01 0.11700 9.00e-02 0.074500 2.20e-01 3.10e-01
SIGNALING BY NOTCH 188 5.78e-02 1.93e-01 0.11600 6.15e-02 0.098300 1.46e-01 2.02e-02
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.84e-01 5.19e-01 0.11600 1.16e-01 0.001300 1.46e-01 9.87e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 4.54e-01 6.77e-01 0.11600 6.11e-02 0.098100 4.46e-01 2.21e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 61 3.05e-01 5.36e-01 0.11500 -1.12e-01 -0.026600 1.30e-01 7.19e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 7.87e-01 8.82e-01 0.11500 8.28e-02 0.079900 5.55e-01 5.69e-01
FATTY ACYL COA BIOSYNTHESIS 32 3.62e-01 5.87e-01 0.11500 -1.01e-01 0.055200 3.24e-01 5.89e-01
PI 3K CASCADE FGFR1 15 7.76e-01 8.76e-01 0.11500 -1.06e-01 -0.043600 4.77e-01 7.70e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 5.67e-01 7.52e-01 0.11500 -2.45e-02 -0.112000 8.19e-01 2.97e-01
CELLULAR RESPONSE TO HEAT STRESS 94 8.74e-02 2.47e-01 0.11500 1.48e-02 -0.114000 8.05e-01 5.70e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 2.66e-01 5.04e-01 0.11500 -3.37e-02 -0.110000 6.19e-01 1.06e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 8.55e-01 9.23e-01 0.11400 -1.02e-01 -0.052700 5.78e-01 7.73e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 5.36e-01 7.30e-01 0.11400 -1.12e-01 -0.024400 2.74e-01 8.11e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 5.27e-01 7.26e-01 0.11400 -6.08e-02 0.096800 6.38e-01 4.54e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 7.46e-01 8.58e-01 0.11400 -1.07e-01 -0.039100 4.44e-01 7.80e-01
SARS COV 1 INFECTION 48 5.09e-01 7.16e-01 0.11400 7.18e-02 0.088700 3.90e-01 2.88e-01
FRS MEDIATED FGFR2 SIGNALING 18 6.19e-01 7.79e-01 0.11400 -1.99e-02 0.112000 8.84e-01 4.09e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 5.02e-01 7.09e-01 0.11300 1.73e-02 0.112000 8.62e-01 2.58e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 6.90e-01 8.25e-01 0.11300 1.11e-01 0.022000 4.01e-01 8.68e-01
INNATE IMMUNE SYSTEM 778 1.36e-07 5.87e-06 0.11300 1.12e-02 0.113000 5.97e-01 9.90e-08
DISEASES OF PROGRAMMED CELL DEATH 55 4.58e-01 6.77e-01 0.11300 9.25e-02 0.065500 2.35e-01 4.01e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.88e-01 8.24e-01 0.11300 -3.68e-02 0.107000 8.19e-01 5.04e-01
O LINKED GLYCOSYLATION 83 1.19e-01 3.01e-01 0.11300 1.70e-02 -0.112000 7.89e-01 7.87e-02
MRNA CAPPING 29 6.69e-01 8.11e-01 0.11200 6.67e-02 0.090500 5.34e-01 3.99e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 5.85e-01 7.58e-01 0.11200 -1.06e-01 0.035900 4.22e-01 7.87e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 44 5.25e-01 7.26e-01 0.11200 -9.75e-02 -0.055100 2.63e-01 5.27e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 5.98e-01 7.64e-01 0.11200 2.98e-02 0.108000 7.82e-01 3.15e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 6.07e-01 7.70e-01 0.11100 1.02e-01 0.044600 3.18e-01 6.63e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.10e-01 6.31e-01 0.11100 -1.11e-01 -0.009210 2.08e-01 9.17e-01
SIGNALING BY WNT IN CANCER 31 6.32e-01 7.87e-01 0.11100 -4.98e-02 -0.099000 6.32e-01 3.40e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 7.13e-01 8.37e-01 0.11000 -1.07e-01 0.026200 5.03e-01 8.70e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 28 4.70e-01 6.84e-01 0.11000 -3.34e-02 0.105000 7.60e-01 3.36e-01
NONHOMOLOGOUS END JOINING NHEJ 44 5.62e-01 7.51e-01 0.11000 -6.89e-02 -0.086000 4.29e-01 3.24e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 7.34e-01 8.50e-01 0.11000 2.65e-02 -0.107000 8.74e-01 5.23e-01
BASE EXCISION REPAIR 57 2.95e-01 5.28e-01 0.11000 1.10e-01 0.001020 1.52e-01 9.89e-01
RHOD GTPASE CYCLE 50 4.95e-01 7.04e-01 0.11000 -9.55e-02 -0.054000 2.43e-01 5.09e-01
MEIOTIC RECOMBINATION 38 3.90e-01 6.13e-01 0.11000 -1.08e-01 0.020500 2.51e-01 8.27e-01
INTRA GOLGI TRAFFIC 43 4.71e-01 6.84e-01 0.10900 -2.50e-02 -0.106000 7.77e-01 2.28e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 5.05e-01 7.11e-01 0.10900 -8.61e-02 0.066800 4.75e-01 5.80e-01
ENDOGENOUS STEROLS 21 6.92e-01 8.26e-01 0.10900 2.41e-02 0.106000 8.48e-01 4.00e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 90 3.17e-01 5.43e-01 0.10900 -6.71e-02 -0.085500 2.72e-01 1.61e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 6.02e-01 7.67e-01 0.10900 -1.03e-01 -0.035300 3.15e-01 7.30e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 2.64e-03 1.95e-02 0.10800 1.08e-01 -0.000284 1.67e-03 9.93e-01
HOST INTERACTIONS OF HIV FACTORS 124 2.14e-01 4.35e-01 0.10800 7.43e-02 0.078900 1.54e-01 1.30e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 7.99e-01 8.92e-01 0.10800 -1.00e-01 -0.041100 5.02e-01 7.83e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 197 5.48e-02 1.86e-01 0.10800 4.18e-02 0.099700 3.13e-01 1.60e-02
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 2.67e-01 5.04e-01 0.10800 7.71e-02 0.075600 1.69e-01 1.77e-01
CELL CELL COMMUNICATION 106 2.01e-01 4.15e-01 0.10800 -1.01e-01 -0.038500 7.33e-02 4.94e-01
L1CAM INTERACTIONS 109 1.27e-01 3.15e-01 0.10800 -1.20e-02 -0.107000 8.29e-01 5.33e-02
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 1.75e-01 3.84e-01 0.10800 8.62e-03 -0.107000 8.95e-01 9.94e-02
MITOTIC G2 G2 M PHASES 184 1.73e-02 8.34e-02 0.10800 1.07e-01 -0.009350 1.22e-02 8.27e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 7.19e-01 8.42e-01 0.10700 6.30e-02 0.087000 5.78e-01 4.43e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 69 1.39e-01 3.29e-01 0.10700 -8.37e-02 0.066600 2.29e-01 3.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 4.30e-01 6.53e-01 0.10600 6.39e-02 -0.084800 5.45e-01 4.22e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 9.62e-02 2.60e-01 0.10600 8.02e-03 0.106000 8.78e-01 4.19e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 8.83e-01 9.40e-01 0.10500 -8.74e-02 -0.059000 6.32e-01 7.47e-01
SENSORY PROCESSING OF SOUND 62 2.10e-01 4.29e-01 0.10500 3.90e-02 -0.097200 5.96e-01 1.86e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 8.14e-01 9.03e-01 0.10500 1.01e-01 0.025800 5.27e-01 8.72e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 8.33e-01 9.14e-01 0.10400 9.70e-02 0.038900 5.45e-01 8.08e-01
TRIGLYCERIDE METABOLISM 24 5.72e-01 7.54e-01 0.10400 -2.51e-02 0.101000 8.32e-01 3.90e-01
SIGNALING BY ACTIVIN 12 8.56e-01 9.24e-01 0.10400 -9.19e-02 -0.049500 5.82e-01 7.67e-01
METABOLISM OF VITAMINS AND COFACTORS 156 1.47e-01 3.42e-01 0.10400 8.86e-02 0.054900 5.64e-02 2.37e-01
IRON UPTAKE AND TRANSPORT 51 5.32e-01 7.30e-01 0.10400 5.42e-02 0.088800 5.03e-01 2.73e-01
HIV TRANSCRIPTION ELONGATION 42 5.20e-01 7.23e-01 0.10400 1.01e-01 0.025200 2.60e-01 7.77e-01
CELLULAR HEXOSE TRANSPORT 11 8.48e-01 9.21e-01 0.10300 9.92e-02 0.029300 5.69e-01 8.66e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 6.47e-01 7.98e-01 0.10300 9.38e-02 0.041500 3.51e-01 6.80e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 6.65e-01 8.10e-01 0.10300 1.02e-01 0.007760 3.96e-01 9.49e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 22 7.32e-01 8.49e-01 0.10200 3.17e-02 0.096900 7.97e-01 4.31e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 62 3.42e-01 5.68e-01 0.10200 -8.52e-03 -0.101000 9.08e-01 1.67e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 5.59e-01 7.50e-01 0.10200 -6.34e-02 -0.079600 4.29e-01 3.21e-01
ESR MEDIATED SIGNALING 167 1.70e-02 8.30e-02 0.10200 -9.06e-02 0.045900 4.37e-02 3.07e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 20 5.94e-01 7.61e-01 0.10200 6.99e-02 -0.073600 5.88e-01 5.69e-01
TRNA PROCESSING 105 1.41e-01 3.32e-01 0.10100 2.61e-03 -0.101000 9.63e-01 7.35e-02
RHOG GTPASE CYCLE 73 1.98e-01 4.11e-01 0.10100 -9.75e-02 0.027200 1.50e-01 6.88e-01
ION TRANSPORT BY P TYPE ATPASES 49 5.16e-01 7.20e-01 0.10100 -9.49e-02 -0.034600 2.51e-01 6.75e-01
DNA STRAND ELONGATION 32 7.07e-01 8.33e-01 0.10100 7.32e-02 0.069400 4.73e-01 4.97e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 75 2.22e-01 4.42e-01 0.10100 -1.34e-02 0.099700 8.41e-01 1.36e-01
STRIATED MUSCLE CONTRACTION 25 5.57e-01 7.49e-01 0.09990 -4.11e-02 0.091000 7.22e-01 4.31e-01
GABA B RECEPTOR ACTIVATION 39 5.83e-01 7.58e-01 0.09960 -9.55e-02 -0.028400 3.02e-01 7.59e-01
CD28 CO STIMULATION 31 4.78e-01 6.89e-01 0.09910 -8.62e-02 0.049000 4.06e-01 6.37e-01
MITOCHONDRIAL BIOGENESIS 92 1.04e-01 2.74e-01 0.09910 -6.25e-02 0.076900 3.00e-01 2.03e-01
PYROPTOSIS 21 6.63e-01 8.10e-01 0.09880 -1.41e-02 0.097800 9.11e-01 4.38e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 4.49e-01 6.73e-01 0.09880 9.85e-02 -0.007930 2.64e-01 9.28e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 4.55e-01 6.77e-01 0.09870 9.52e-02 0.026300 2.14e-01 7.31e-01
SIGNALING BY NODAL 15 8.24e-01 9.09e-01 0.09830 -9.26e-02 -0.033100 5.35e-01 8.24e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 7.89e-01 8.83e-01 0.09830 8.86e-02 0.042400 4.93e-01 7.42e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 8.65e-01 9.29e-01 0.09810 -9.62e-02 -0.019500 5.99e-01 9.15e-01
G ALPHA I SIGNALLING EVENTS 205 7.43e-02 2.24e-01 0.09770 -9.23e-02 -0.031900 2.29e-02 4.32e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 9.04e-01 9.48e-01 0.09720 -7.12e-02 -0.066200 6.97e-01 7.17e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.32e-01 8.49e-01 0.09650 -4.45e-02 0.085600 7.73e-01 5.79e-01
P38MAPK EVENTS 12 7.55e-01 8.64e-01 0.09640 7.22e-02 -0.063900 6.65e-01 7.02e-01
APOPTOSIS 163 1.60e-01 3.61e-01 0.09570 4.02e-02 0.086800 3.77e-01 5.60e-02
DEADENYLATION DEPENDENT MRNA DECAY 55 5.63e-01 7.51e-01 0.09410 -8.27e-02 -0.044700 2.89e-01 5.66e-01
ACYL CHAIN REMODELLING OF PS 14 8.60e-01 9.26e-01 0.09380 4.05e-02 0.084600 7.93e-01 5.84e-01
NEDDYLATION 219 1.30e-01 3.18e-01 0.09360 7.18e-02 0.060100 6.74e-02 1.26e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 4.46e-01 6.71e-01 0.09340 -3.06e-02 -0.088300 6.61e-01 2.05e-01
FRS MEDIATED FGFR1 SIGNALING 17 8.17e-01 9.05e-01 0.09340 2.89e-02 0.088800 8.37e-01 5.26e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 20 8.21e-01 9.07e-01 0.09330 7.86e-02 0.050300 5.43e-01 6.97e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.75e-01 9.36e-01 0.09300 9.16e-02 0.016200 6.16e-01 9.29e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 6.15e-01 7.76e-01 0.09290 9.19e-02 -0.013900 4.00e-01 8.99e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 7.25e-01 8.46e-01 0.09270 9.21e-02 0.010900 4.45e-01 9.28e-01
UNWINDING OF DNA 12 8.94e-01 9.44e-01 0.09260 -7.35e-02 -0.056300 6.59e-01 7.35e-01
SIGNALING BY PTK6 50 4.23e-01 6.46e-01 0.09220 -1.49e-02 0.090900 8.55e-01 2.66e-01
SIGNALING BY WNT 268 3.17e-02 1.28e-01 0.09210 1.64e-02 0.090600 6.44e-01 1.08e-02
METABOLISM OF STEROIDS 114 3.13e-01 5.43e-01 0.09160 8.24e-02 0.040000 1.29e-01 4.61e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 6.87e-01 8.24e-01 0.09110 3.39e-02 0.084600 7.28e-01 3.87e-01
HCMV INFECTION 104 1.45e-01 3.39e-01 0.09080 8.54e-02 -0.030900 1.33e-01 5.86e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 8.91e-01 9.42e-01 0.09070 6.95e-02 0.058300 6.65e-01 7.16e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 9.08e-01 9.48e-01 0.09060 6.89e-02 0.058900 6.92e-01 7.35e-01
CDC42 GTPASE CYCLE 152 2.70e-01 5.05e-01 0.09030 -6.44e-02 -0.063300 1.71e-01 1.78e-01
CHROMATIN MODIFYING ENZYMES 219 6.17e-02 2.01e-01 0.09020 -1.32e-02 -0.089200 7.36e-01 2.32e-02
RESOLUTION OF SISTER CHROMATID COHESION 102 1.45e-01 3.39e-01 0.09010 3.67e-02 -0.082300 5.22e-01 1.51e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 6.26e-01 7.84e-01 0.08980 6.42e-02 -0.062800 5.94e-01 6.02e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 47 6.65e-01 8.10e-01 0.08950 5.56e-02 0.070200 5.10e-01 4.05e-01
G2 M DNA DAMAGE CHECKPOINT 66 5.14e-01 7.19e-01 0.08940 -8.21e-02 -0.035600 2.49e-01 6.17e-01
SIGNALING BY NTRK3 TRKC 17 8.07e-01 8.98e-01 0.08940 -1.33e-02 -0.088400 9.24e-01 5.28e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 3.72e-02 1.44e-01 0.08930 8.44e-02 -0.029400 4.81e-02 4.91e-01
MTORC1 MEDIATED SIGNALLING 24 6.87e-01 8.24e-01 0.08930 -1.04e-02 0.088600 9.30e-01 4.52e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 8.00e-01 8.92e-01 0.08920 8.56e-02 0.025100 5.08e-01 8.46e-01
GPCR LIGAND BINDING 278 8.78e-02 2.47e-01 0.08910 4.98e-02 0.073900 1.54e-01 3.42e-02
ORGANELLE BIOGENESIS AND MAINTENANCE 283 1.79e-02 8.57e-02 0.08860 8.86e-02 -0.002490 1.05e-02 9.43e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 6.72e-01 8.13e-01 0.08860 8.49e-02 -0.025400 4.81e-01 8.33e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 9.08e-01 9.48e-01 0.08850 4.87e-02 0.073900 7.80e-01 6.71e-01
METALLOPROTEASE DUBS 26 7.29e-01 8.49e-01 0.08780 1.34e-02 0.086700 9.06e-01 4.44e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 7.35e-01 8.50e-01 0.08770 3.74e-02 -0.079300 7.90e-01 5.71e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 6.94e-01 8.28e-01 0.08700 5.20e-02 0.069800 5.51e-01 4.23e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 3.86e-01 6.12e-01 0.08690 8.64e-02 0.009220 1.90e-01 8.89e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 118 1.32e-01 3.21e-01 0.08690 3.12e-02 -0.081000 5.58e-01 1.29e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 3.96e-02 1.49e-01 0.08670 -9.22e-03 0.086200 8.13e-01 2.68e-02
RUNX2 REGULATES BONE DEVELOPMENT 28 5.92e-01 7.61e-01 0.08660 -5.22e-02 0.069100 6.32e-01 5.27e-01
INSULIN RECEPTOR RECYCLING 20 8.47e-01 9.21e-01 0.08640 7.11e-02 0.049000 5.82e-01 7.04e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 92 4.53e-01 6.77e-01 0.08630 4.35e-02 0.074600 4.71e-01 2.17e-01
RNA POLYMERASE III TRANSCRIPTION 41 5.54e-01 7.47e-01 0.08630 8.59e-02 -0.008290 3.41e-01 9.27e-01
INTERLEUKIN 27 SIGNALING 10 9.05e-01 9.48e-01 0.08620 -8.15e-02 -0.028100 6.55e-01 8.78e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 6.45e-01 7.98e-01 0.08590 8.02e-02 -0.030800 4.79e-01 7.86e-01
RESOLUTION OF ABASIC SITES AP SITES 37 5.26e-01 7.26e-01 0.08570 7.72e-02 -0.037300 4.17e-01 6.95e-01
SIGNALING BY SCF KIT 41 5.35e-01 7.30e-01 0.08560 -8.38e-02 0.017300 3.53e-01 8.48e-01
SIGNALING BY INTERLEUKINS 344 1.83e-02 8.69e-02 0.08560 1.05e-02 0.085000 7.37e-01 6.91e-03
RHO GTPASE CYCLE 425 3.57e-02 1.40e-01 0.08550 -6.91e-02 -0.050300 1.48e-02 7.62e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 6.67e-01 8.10e-01 0.08530 -5.09e-02 -0.068400 5.29e-01 3.98e-01
SIGNAL TRANSDUCTION BY L1 21 8.46e-01 9.21e-01 0.08520 -6.84e-02 -0.050800 5.87e-01 6.87e-01
INTERLEUKIN 37 SIGNALING 18 8.70e-01 9.33e-01 0.08470 6.51e-02 0.054300 6.33e-01 6.90e-01
NEGATIVE REGULATION OF FLT3 14 8.87e-01 9.41e-01 0.08440 7.54e-02 0.037900 6.25e-01 8.06e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 4.99e-01 7.06e-01 0.08430 -8.11e-02 0.022900 3.47e-01 7.91e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 3.41e-01 5.68e-01 0.08420 -8.10e-02 -0.022900 1.46e-01 6.81e-01
PEPTIDE HORMONE METABOLISM 59 3.57e-01 5.82e-01 0.08400 -4.82e-02 0.068700 5.22e-01 3.61e-01
SIGNALING BY FGFR1 43 6.65e-01 8.10e-01 0.08390 -7.94e-02 -0.027100 3.68e-01 7.58e-01
EXTRACELLULAR MATRIX ORGANIZATION 243 1.57e-01 3.57e-01 0.08390 6.76e-02 0.049600 6.99e-02 1.84e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 539 1.11e-04 1.55e-03 0.08370 -6.82e-02 0.048500 6.94e-03 5.50e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 7.51e-01 8.60e-01 0.08350 8.34e-02 0.004670 4.80e-01 9.68e-01
HIV TRANSCRIPTION INITIATION 45 5.82e-01 7.58e-01 0.08330 3.43e-03 0.083300 9.68e-01 3.34e-01
SIGNALING BY NUCLEAR RECEPTORS 223 2.16e-02 9.81e-02 0.08300 -5.72e-02 0.060100 1.41e-01 1.23e-01
RNA POLYMERASE II TRANSCRIPTION 1087 5.43e-05 8.73e-04 0.08270 -7.95e-02 -0.022700 1.12e-05 2.11e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 49 4.77e-01 6.89e-01 0.08250 2.54e-02 -0.078500 7.59e-01 3.42e-01
SIGNALING BY RETINOIC ACID 32 7.82e-01 8.78e-01 0.08220 4.34e-02 0.069800 6.71e-01 4.95e-01
ECM PROTEOGLYCANS 67 5.66e-01 7.52e-01 0.08200 3.24e-02 0.075300 6.47e-01 2.86e-01
HCMV LATE EVENTS 66 5.27e-01 7.26e-01 0.08200 -2.02e-02 -0.079500 7.77e-01 2.64e-01
TRIGLYCERIDE BIOSYNTHESIS 10 9.31e-01 9.61e-01 0.08190 6.15e-02 0.054100 7.37e-01 7.67e-01
REGULATION OF BACH1 ACTIVITY 11 8.74e-01 9.36e-01 0.08170 2.14e-03 -0.081700 9.90e-01 6.39e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 6.46e-01 7.98e-01 0.08140 -5.98e-02 -0.055200 4.16e-01 4.52e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 7.04e-01 8.30e-01 0.08080 7.17e-02 0.037300 4.05e-01 6.65e-01
FLT3 SIGNALING 36 7.32e-01 8.49e-01 0.08060 -7.59e-02 -0.027000 4.31e-01 7.79e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.36e-01 9.15e-01 0.08000 -3.17e-02 0.073500 8.49e-01 6.59e-01
ION CHANNEL TRANSPORT 140 3.92e-01 6.13e-01 0.07950 -5.74e-02 -0.055100 2.42e-01 2.61e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 3.16e-01 5.43e-01 0.07930 -4.55e-02 0.064900 4.99e-01 3.34e-01
SIGNALING BY EGFR 47 4.79e-01 6.89e-01 0.07920 -6.34e-02 0.047500 4.52e-01 5.73e-01
RHOBTB3 ATPASE CYCLE 10 8.86e-01 9.41e-01 0.07900 7.29e-03 -0.078700 9.68e-01 6.67e-01
PKMTS METHYLATE HISTONE LYSINES 49 6.98e-01 8.28e-01 0.07860 -6.95e-02 -0.036700 4.00e-01 6.57e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 6.02e-01 7.67e-01 0.07810 7.39e-02 0.025400 3.15e-01 7.29e-01
METABOLISM OF LIPIDS 613 2.88e-03 2.09e-02 0.07790 9.04e-03 0.077400 7.03e-01 1.12e-03
CTLA4 INHIBITORY SIGNALING 20 7.62e-01 8.68e-01 0.07790 2.51e-02 -0.073700 8.46e-01 5.68e-01
NICOTINATE METABOLISM 25 7.03e-01 8.30e-01 0.07740 -7.03e-02 0.032500 5.43e-01 7.79e-01
HIV INFECTION 220 2.44e-01 4.76e-01 0.07740 6.06e-02 0.048100 1.22e-01 2.20e-01
AQUAPORIN MEDIATED TRANSPORT 39 6.58e-01 8.06e-01 0.07720 -7.72e-02 0.000250 4.04e-01 9.98e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 7.88e-01 8.82e-01 0.07720 -2.85e-02 -0.071700 7.84e-01 4.90e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 8.38e-01 9.16e-01 0.07710 -4.36e-02 0.063500 7.94e-01 7.03e-01
PI3K AKT SIGNALING IN CANCER 88 4.57e-01 6.77e-01 0.07640 -7.51e-02 -0.014000 2.24e-01 8.20e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 86 3.98e-01 6.20e-01 0.07590 -7.58e-02 0.003530 2.24e-01 9.55e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 8.17e-01 9.05e-01 0.07570 5.81e-02 -0.048600 7.07e-01 7.53e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 93 5.67e-01 7.52e-01 0.07560 -4.96e-02 -0.057100 4.09e-01 3.42e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 8.10e-01 9.00e-01 0.07540 -2.60e-02 -0.070700 8.12e-01 5.17e-01
MITOTIC SPINDLE CHECKPOINT 97 4.03e-01 6.24e-01 0.07520 -6.67e-03 -0.074900 9.10e-01 2.03e-01
HIV LIFE CYCLE 142 2.21e-01 4.41e-01 0.07450 6.83e-03 -0.074200 8.88e-01 1.27e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 4.16e-01 6.38e-01 0.07410 4.33e-02 0.060100 3.67e-01 2.10e-01
EGFR DOWNREGULATION 28 6.99e-01 8.28e-01 0.07410 -6.79e-02 0.029500 5.34e-01 7.87e-01
SHC MEDIATED CASCADE FGFR1 15 8.79e-01 9.40e-01 0.07400 1.18e-02 0.073000 9.37e-01 6.24e-01
PROGRAMMED CELL DEATH 185 3.30e-01 5.59e-01 0.07360 4.14e-02 0.060900 3.32e-01 1.54e-01
LEISHMANIA INFECTION 197 7.28e-02 2.22e-01 0.07350 -5.95e-02 0.043100 1.50e-01 2.98e-01
RAF ACTIVATION 34 7.78e-01 8.76e-01 0.07270 -2.08e-02 -0.069700 8.34e-01 4.82e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 9.20e-01 9.56e-01 0.07240 5.21e-02 0.050300 7.27e-01 7.36e-01
HOMOLOGY DIRECTED REPAIR 107 5.52e-01 7.44e-01 0.07240 -5.30e-02 -0.049300 3.44e-01 3.79e-01
SARS COV INFECTIONS 140 4.44e-01 6.68e-01 0.07230 5.99e-02 0.040400 2.21e-01 4.09e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 6.78e-01 8.17e-01 0.07220 -4.18e-02 0.058900 6.92e-01 5.77e-01
SIGNALING BY FGFR2 IN DISEASE 36 6.83e-01 8.21e-01 0.07220 -1.21e-02 0.071200 9.00e-01 4.60e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 36 6.25e-01 7.84e-01 0.07190 -5.10e-02 0.050600 5.96e-01 5.99e-01
RHO GTPASES ACTIVATE FORMINS 119 2.52e-01 4.90e-01 0.07160 2.49e-02 -0.067100 6.40e-01 2.06e-01
DNA DAMAGE BYPASS 46 7.08e-01 8.33e-01 0.07130 -6.95e-02 -0.015900 4.15e-01 8.52e-01
RHO GTPASES ACTIVATE PKNS 48 5.76e-01 7.54e-01 0.07070 -2.65e-02 0.065600 7.51e-01 4.32e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 6.31e-01 7.87e-01 0.07040 -6.00e-02 0.036900 5.22e-01 6.94e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 9.16e-01 9.53e-01 0.07020 -1.52e-02 -0.068500 9.27e-01 6.81e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 3.88e-01 6.13e-01 0.06990 -1.66e-02 -0.067900 7.40e-01 1.75e-01
DUAL INCISION IN TC NER 64 7.20e-01 8.42e-01 0.06920 4.54e-02 0.052300 5.31e-01 4.69e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 6.16e-01 7.77e-01 0.06910 -6.12e-03 -0.068800 9.34e-01 3.53e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 6.11e-01 7.73e-01 0.06910 -5.05e-02 0.047200 5.76e-01 6.01e-01
TOLL LIKE RECEPTOR CASCADES 137 2.68e-01 5.04e-01 0.06870 -6.76e-02 0.012300 1.73e-01 8.04e-01
SIGNALING BY NOTCH3 48 7.58e-01 8.67e-01 0.06820 -6.20e-02 -0.028500 4.58e-01 7.33e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 7.28e-01 8.48e-01 0.06790 -6.75e-02 -0.007170 4.49e-01 9.36e-01
DISEASES OF MITOTIC CELL CYCLE 37 7.03e-01 8.30e-01 0.06750 -1.38e-02 0.066100 8.85e-01 4.87e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.95e-01 7.04e-01 0.06750 -3.53e-02 -0.057500 4.77e-01 2.47e-01
SURFACTANT METABOLISM 16 9.15e-01 9.53e-01 0.06750 6.08e-02 0.029300 6.74e-01 8.39e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 9.49e-01 9.70e-01 0.06680 5.85e-02 0.032200 7.49e-01 8.60e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 6.99e-01 8.28e-01 0.06610 5.82e-02 -0.031500 5.57e-01 7.51e-01
MEIOTIC SYNAPSIS 40 6.70e-01 8.11e-01 0.06600 2.44e-02 -0.061400 7.90e-01 5.02e-01
SIGNALING BY NOTCH2 32 7.21e-01 8.43e-01 0.06570 -5.93e-02 0.028300 5.61e-01 7.82e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 192 1.42e-01 3.33e-01 0.06570 -5.86e-02 0.029600 1.62e-01 4.80e-01
OTHER INTERLEUKIN SIGNALING 20 8.45e-01 9.21e-01 0.06560 6.52e-02 -0.007420 6.14e-01 9.54e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 7.65e-01 8.70e-01 0.06540 3.82e-02 0.053100 6.18e-01 4.88e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 8.83e-01 9.40e-01 0.06540 1.94e-02 0.062400 8.78e-01 6.20e-01
RND3 GTPASE CYCLE 37 8.40e-01 9.16e-01 0.06530 -3.77e-02 -0.053400 6.92e-01 5.74e-01
G ALPHA Q SIGNALLING EVENTS 165 2.66e-01 5.04e-01 0.06450 -6.58e-03 0.064200 8.84e-01 1.56e-01
AMINO ACIDS REGULATE MTORC1 51 6.24e-01 7.84e-01 0.06450 6.12e-02 -0.020100 4.49e-01 8.04e-01
PENTOSE PHOSPHATE PATHWAY 13 9.45e-01 9.69e-01 0.06370 4.09e-02 0.048900 7.99e-01 7.60e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 8.99e-01 9.46e-01 0.06360 -2.23e-02 -0.059600 8.63e-01 6.45e-01
SMOOTH MUSCLE CONTRACTION 34 8.35e-01 9.15e-01 0.06320 2.15e-02 0.059400 8.28e-01 5.49e-01
SIGNALLING TO RAS 19 8.27e-01 9.12e-01 0.06300 4.14e-02 -0.047500 7.55e-01 7.20e-01
TRANSLESION SYNTHESIS BY POLK 17 8.52e-01 9.21e-01 0.06270 -5.56e-02 0.029000 6.92e-01 8.36e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 2.55e-01 4.91e-01 0.06260 6.12e-02 0.013400 1.05e-01 7.22e-01
REGULATION OF TP53 ACTIVITY 149 3.42e-01 5.68e-01 0.06230 3.12e-03 -0.062200 9.48e-01 1.90e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 8.51e-01 9.21e-01 0.06150 -3.82e-02 0.048200 7.85e-01 7.31e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.23e-01 9.57e-01 0.06150 4.33e-02 0.043600 7.38e-01 7.36e-01
SIGNALING BY INSULIN RECEPTOR 63 7.76e-01 8.76e-01 0.06140 -4.59e-02 -0.040800 5.29e-01 5.76e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 6.36e-01 7.92e-01 0.06050 -2.10e-02 -0.056700 7.25e-01 3.42e-01
NERVOUS SYSTEM DEVELOPMENT 550 7.94e-02 2.34e-01 0.06050 2.20e-02 0.056300 3.79e-01 2.44e-02
SIGNALING BY MET 75 7.13e-01 8.37e-01 0.06000 2.42e-02 0.054900 7.17e-01 4.11e-01
RHOC GTPASE CYCLE 73 6.59e-01 8.06e-01 0.05990 -5.94e-02 -0.008130 3.81e-01 9.04e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 8.88e-01 9.41e-01 0.05980 2.31e-02 0.055200 8.39e-01 6.26e-01
VESICLE MEDIATED TRANSPORT 611 6.45e-03 3.95e-02 0.05940 2.93e-02 -0.051600 2.18e-01 2.99e-02
G ALPHA 12 13 SIGNALLING EVENTS 74 5.24e-01 7.26e-01 0.05910 -3.72e-02 0.045900 5.81e-01 4.95e-01
PROCESSING AND ACTIVATION OF SUMO 10 9.51e-01 9.71e-01 0.05900 1.51e-02 0.057000 9.34e-01 7.55e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 7.76e-01 8.76e-01 0.05890 3.24e-04 0.058900 9.97e-01 5.14e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 7.79e-01 8.76e-01 0.05880 4.86e-02 0.033100 4.98e-01 6.44e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 8.39e-01 9.16e-01 0.05850 -3.06e-02 -0.049900 7.22e-01 5.63e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 8.87e-01 9.41e-01 0.05830 5.34e-02 0.023300 6.25e-01 8.31e-01
REGULATION OF SIGNALING BY CBL 22 8.37e-01 9.15e-01 0.05820 -5.18e-02 0.026600 6.74e-01 8.29e-01
MEMBRANE TRAFFICKING 581 1.23e-02 6.63e-02 0.05800 2.30e-02 -0.053200 3.45e-01 2.91e-02
SIGNALING BY BRAF AND RAF FUSIONS 60 7.79e-01 8.76e-01 0.05760 -5.27e-02 -0.023100 4.80e-01 7.57e-01
HEME BIOSYNTHESIS 13 9.13e-01 9.52e-01 0.05740 -1.29e-02 0.056000 9.36e-01 7.27e-01
NICOTINAMIDE SALVAGING 16 9.45e-01 9.69e-01 0.05740 -4.44e-02 -0.036300 7.59e-01 8.01e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 7.77e-01 8.76e-01 0.05680 -4.25e-02 0.037700 6.82e-01 7.17e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.22e-01 9.57e-01 0.05610 -2.25e-02 0.051400 8.97e-01 7.68e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 629 1.29e-01 3.15e-01 0.05570 -3.39e-02 -0.044200 1.49e-01 5.93e-02
NEPHRIN FAMILY INTERACTIONS 23 8.85e-01 9.41e-01 0.05530 -5.52e-02 -0.002240 6.47e-01 9.85e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 8.31e-01 9.14e-01 0.05460 5.22e-02 -0.016300 6.33e-01 8.82e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 8.81e-01 9.40e-01 0.05450 5.45e-02 -0.002330 6.51e-01 9.85e-01
SIGNALING BY FGFR3 35 8.22e-01 9.08e-01 0.05420 -4.15e-03 0.054100 9.66e-01 5.80e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 347 1.07e-01 2.77e-01 0.05410 -1.73e-02 0.051300 5.80e-01 1.01e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 9.25e-01 9.58e-01 0.05310 3.36e-02 -0.041100 8.47e-01 8.13e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 67 7.19e-01 8.42e-01 0.05300 1.51e-03 0.053000 9.83e-01 4.53e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 7.02e-01 8.30e-01 0.05270 1.88e-02 -0.049200 8.08e-01 5.24e-01
RAB REGULATION OF TRAFFICKING 119 4.69e-01 6.83e-01 0.05260 2.02e-02 -0.048500 7.03e-01 3.61e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 8.49e-01 9.21e-01 0.05210 5.00e-02 0.014600 5.71e-01 8.69e-01
ONCOGENIC MAPK SIGNALING 77 6.03e-01 7.67e-01 0.05170 -4.34e-02 0.028200 5.11e-01 6.69e-01
UB SPECIFIC PROCESSING PROTEASES 167 5.61e-01 7.50e-01 0.05150 4.83e-02 0.017900 2.82e-01 6.90e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 8.29e-01 9.12e-01 0.05110 -4.71e-02 0.019800 6.50e-01 8.48e-01
CELLULAR SENESCENCE 143 4.01e-01 6.23e-01 0.05050 3.63e-02 -0.035200 4.55e-01 4.68e-01
EPH EPHRIN SIGNALING 92 6.70e-01 8.11e-01 0.05030 -5.03e-02 -0.002460 4.05e-01 9.68e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 7.67e-01 8.70e-01 0.05020 -2.29e-02 -0.044600 7.10e-01 4.70e-01
TP53 REGULATES METABOLIC GENES 85 5.86e-01 7.58e-01 0.05010 -3.23e-02 0.038200 6.06e-01 5.43e-01
DNA REPAIR 291 1.85e-01 3.93e-01 0.05000 2.11e-02 -0.045400 5.37e-01 1.84e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 7.16e-01 8.40e-01 0.04930 4.93e-02 -0.000566 4.58e-01 9.93e-01
DEATH RECEPTOR SIGNALLING 133 6.91e-01 8.25e-01 0.04870 -2.33e-02 -0.042700 6.43e-01 3.95e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 117 6.46e-01 7.98e-01 0.04860 7.02e-03 0.048100 8.96e-01 3.69e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 366 1.90e-01 4.00e-01 0.04860 -5.47e-03 0.048300 8.58e-01 1.14e-01
RHOA GTPASE CYCLE 142 6.84e-01 8.22e-01 0.04830 -2.47e-02 -0.041500 6.11e-01 3.93e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 8.70e-01 9.33e-01 0.04830 3.99e-02 -0.027300 7.35e-01 8.17e-01
ESTROGEN DEPENDENT GENE EXPRESSION 104 5.74e-01 7.54e-01 0.04820 -4.47e-02 0.018100 4.32e-01 7.49e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 466 3.00e-01 5.35e-01 0.04810 -4.11e-02 -0.025100 1.30e-01 3.55e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 8.01e-01 8.92e-01 0.04780 -2.66e-02 -0.039800 6.68e-01 5.22e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.05e-01 9.48e-01 0.04770 9.47e-03 0.046700 9.30e-01 6.63e-01
O LINKED GLYCOSYLATION OF MUCINS 39 8.34e-01 9.15e-01 0.04760 4.68e-02 -0.008720 6.13e-01 9.25e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 7.60e-01 8.67e-01 0.04740 4.71e-02 -0.005020 5.18e-01 9.45e-01
COPII MEDIATED VESICLE TRANSPORT 66 6.91e-01 8.25e-01 0.04720 3.04e-02 -0.036200 6.70e-01 6.11e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 8.81e-01 9.40e-01 0.04700 4.58e-02 -0.010700 6.81e-01 9.24e-01
SIGNALING BY GPCR 494 3.05e-01 5.36e-01 0.04660 -3.96e-02 -0.024600 1.33e-01 3.51e-01
DEVELOPMENTAL BIOLOGY 821 6.41e-02 2.05e-01 0.04650 5.48e-03 0.046200 7.91e-01 2.54e-02
SIGNALING BY FGFR4 33 8.90e-01 9.42e-01 0.04630 4.79e-03 0.046100 9.62e-01 6.47e-01
M PHASE 341 1.78e-01 3.88e-01 0.04550 3.73e-02 -0.026200 2.38e-01 4.07e-01
REGULATION OF INSULIN SECRETION 71 7.67e-01 8.70e-01 0.04540 -4.54e-02 0.000626 5.09e-01 9.93e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 8.09e-01 8.99e-01 0.04530 -4.26e-04 -0.045300 9.96e-01 5.51e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 9.56e-01 9.75e-01 0.04530 -3.60e-02 -0.027400 7.80e-01 8.32e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 7.49e-01 8.59e-01 0.04460 -4.39e-02 0.007850 5.22e-01 9.09e-01
ADAPTIVE IMMUNE SYSTEM 601 7.15e-02 2.19e-01 0.04430 -1.72e-02 0.040800 4.72e-01 8.92e-02
RHO GTPASE EFFECTORS 251 4.96e-01 7.04e-01 0.04340 -4.25e-02 -0.008920 2.47e-01 8.08e-01
POTENTIAL THERAPEUTICS FOR SARS 77 7.56e-01 8.65e-01 0.04330 4.31e-02 -0.004430 5.14e-01 9.46e-01
TRANSCRIPTION OF THE HIV GENOME 67 8.59e-01 9.26e-01 0.04310 3.88e-02 0.018800 5.83e-01 7.90e-01
PHOSPHOLIPID METABOLISM 185 6.74e-01 8.14e-01 0.04280 -2.08e-02 -0.037400 6.27e-01 3.81e-01
HEMOSTASIS 471 1.60e-01 3.62e-01 0.04230 -4.02e-02 0.013200 1.36e-01 6.25e-01
REGULATED NECROSIS 46 8.95e-01 9.44e-01 0.04200 1.30e-02 0.040000 8.79e-01 6.39e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 8.51e-01 9.21e-01 0.04180 -3.28e-02 0.025800 7.30e-01 7.86e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 26 8.99e-01 9.46e-01 0.04110 -2.03e-02 0.035700 8.58e-01 7.52e-01
MET ACTIVATES PTK2 SIGNALING 29 8.91e-01 9.42e-01 0.04080 3.66e-02 -0.018100 7.33e-01 8.66e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 9.11e-01 9.51e-01 0.04030 3.87e-02 -0.011400 7.33e-01 9.20e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 8.19e-01 9.06e-01 0.04020 -3.37e-03 -0.040000 9.60e-01 5.52e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 9.22e-01 9.57e-01 0.03990 -2.97e-02 -0.026700 7.22e-01 7.49e-01
FLT3 SIGNALING IN DISEASE 28 9.38e-01 9.66e-01 0.03970 9.40e-03 0.038600 9.31e-01 7.24e-01
PRE NOTCH EXPRESSION AND PROCESSING 64 9.01e-01 9.47e-01 0.03910 -2.54e-02 -0.029700 7.26e-01 6.81e-01
MET PROMOTES CELL MOTILITY 39 9.06e-01 9.48e-01 0.03870 -3.86e-02 -0.002440 6.77e-01 9.79e-01
N GLYCAN ANTENNAE ELONGATION 15 9.51e-01 9.71e-01 0.03850 -1.27e-02 0.036400 9.32e-01 8.07e-01
NUCLEOTIDE EXCISION REPAIR 109 7.79e-01 8.76e-01 0.03830 3.79e-02 0.005890 4.95e-01 9.15e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 51 8.51e-01 9.21e-01 0.03750 -1.26e-02 0.035300 8.76e-01 6.63e-01
INTEGRIN SIGNALING 24 9.24e-01 9.58e-01 0.03750 -1.54e-02 0.034100 8.96e-01 7.72e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 9.31e-01 9.61e-01 0.03670 3.57e-02 -0.008770 7.58e-01 9.39e-01
G ALPHA S SIGNALLING EVENTS 105 7.45e-01 8.58e-01 0.03570 -1.04e-02 0.034200 8.54e-01 5.46e-01
DNA DOUBLE STRAND BREAK RESPONSE 53 8.46e-01 9.21e-01 0.03550 2.20e-02 -0.027800 7.82e-01 7.26e-01
TRANSCRIPTIONAL REGULATION BY TP53 340 5.78e-01 7.56e-01 0.03530 -1.23e-02 -0.033100 6.97e-01 2.96e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 9.45e-01 9.69e-01 0.03490 3.49e-02 0.000468 7.58e-01 9.97e-01
CELL CYCLE CHECKPOINTS 242 7.45e-01 8.58e-01 0.03400 2.28e-02 0.025200 5.43e-01 5.00e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 9.48e-01 9.70e-01 0.03360 3.25e-02 -0.008650 7.92e-01 9.44e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 9.60e-01 9.78e-01 0.03210 9.71e-03 0.030600 9.28e-01 7.76e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 9.77e-01 9.90e-01 0.03120 2.64e-02 0.016600 8.34e-01 8.96e-01
TRANSPORT OF SMALL MOLECULES 580 2.95e-01 5.28e-01 0.03060 -1.21e-02 0.028100 6.19e-01 2.50e-01
SEMAPHORIN INTERACTIONS 64 8.63e-01 9.28e-01 0.03030 2.34e-02 -0.019200 7.46e-01 7.91e-01
SENSORY PERCEPTION 147 7.62e-01 8.68e-01 0.03020 5.16e-03 -0.029800 9.14e-01 5.33e-01
CELL CYCLE MITOTIC 474 3.52e-01 5.75e-01 0.03000 1.87e-02 -0.023500 4.86e-01 3.82e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1216 1.05e-01 2.74e-01 0.02980 9.89e-03 -0.028100 5.65e-01 1.02e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.64e-01 9.80e-01 0.02950 -2.53e-02 -0.015100 7.90e-01 8.73e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 9.63e-01 9.80e-01 0.02950 -2.83e-02 0.008140 8.27e-01 9.50e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 8.83e-01 9.40e-01 0.02940 -2.49e-02 0.015600 7.41e-01 8.36e-01
PLATELET AGGREGATION PLUG FORMATION 32 9.41e-01 9.68e-01 0.02930 8.48e-03 -0.028100 9.34e-01 7.83e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 9.47e-01 9.70e-01 0.02870 -1.27e-02 0.025800 9.07e-01 8.13e-01
INTEGRIN CELL SURFACE INTERACTIONS 71 9.08e-01 9.48e-01 0.02860 -2.85e-02 -0.002440 6.78e-01 9.72e-01
SIGNALING BY FGFR IN DISEASE 55 9.41e-01 9.68e-01 0.02810 -2.70e-02 -0.007940 7.30e-01 9.19e-01
INTEGRATION OF ENERGY METABOLISM 98 8.28e-01 9.12e-01 0.02770 2.06e-02 -0.018500 7.25e-01 7.52e-01
OXIDATIVE STRESS INDUCED SENESCENCE 79 8.62e-01 9.28e-01 0.02740 2.18e-02 -0.016600 7.37e-01 7.99e-01
DUAL INCISION IN GG NER 40 9.33e-01 9.62e-01 0.02660 1.44e-02 -0.022300 8.75e-01 8.07e-01
CONDENSATION OF PROPHASE CHROMOSOMES 28 9.69e-01 9.84e-01 0.02650 -2.62e-02 -0.003920 8.11e-01 9.71e-01
MAPK FAMILY SIGNALING CASCADES 287 7.27e-01 8.48e-01 0.02560 1.24e-03 0.025500 9.71e-01 4.58e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 281 7.77e-01 8.76e-01 0.02540 -2.44e-02 -0.006900 4.82e-01 8.43e-01
PERK REGULATES GENE EXPRESSION 28 9.69e-01 9.84e-01 0.02490 -4.64e-05 -0.024900 1.00e+00 8.20e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.86e-01 9.94e-01 0.02380 -6.59e-03 0.022900 9.70e-01 8.95e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 9.88e-01 9.94e-01 0.02340 2.33e-02 0.002570 8.84e-01 9.87e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 9.39e-01 9.67e-01 0.02300 1.99e-02 0.011700 7.28e-01 8.38e-01
METABOLISM OF PORPHYRINS 19 9.81e-01 9.93e-01 0.02280 -2.26e-02 0.002740 8.64e-01 9.83e-01
MYD88 INDEPENDENT TLR4 CASCADE 92 8.96e-01 9.45e-01 0.02210 -1.87e-02 0.011700 7.57e-01 8.46e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 9.87e-01 9.94e-01 0.02070 2.05e-02 -0.002540 8.91e-01 9.86e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 9.87e-01 9.94e-01 0.01950 -3.73e-03 -0.019100 9.76e-01 8.77e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 9.69e-01 9.84e-01 0.01940 -1.93e-02 -0.002380 8.12e-01 9.77e-01
CARGO CONCENTRATION IN THE ER 31 9.73e-01 9.87e-01 0.01910 8.79e-03 -0.017000 9.32e-01 8.70e-01
CELL CYCLE 589 6.47e-01 7.98e-01 0.01820 6.93e-03 -0.016800 7.75e-01 4.87e-01
TRANSLESION SYNTHESIS BY POLH 19 9.85e-01 9.94e-01 0.01820 1.66e-02 -0.007500 9.00e-01 9.55e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 9.90e-01 9.94e-01 0.01700 6.10e-04 0.017000 9.96e-01 8.93e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.92e-01 9.95e-01 0.01620 -3.91e-03 -0.015700 9.75e-01 9.01e-01
PLATELET SENSITIZATION BY LDL 15 9.91e-01 9.94e-01 0.01580 1.36e-02 -0.007990 9.27e-01 9.57e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 9.30e-01 9.61e-01 0.01550 -1.13e-02 -0.010600 7.42e-01 7.58e-01
NOD1 2 SIGNALING PATHWAY 34 9.88e-01 9.94e-01 0.01240 -4.99e-03 0.011400 9.60e-01 9.09e-01
SIGNALING BY NOTCH1 75 9.89e-01 9.94e-01 0.01180 -7.29e-03 -0.009280 9.13e-01 8.90e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 9.82e-01 9.93e-01 0.01070 9.23e-04 -0.010600 9.88e-01 8.67e-01
MTOR SIGNALLING 40 9.93e-01 9.95e-01 0.00885 8.42e-03 -0.002730 9.27e-01 9.76e-01
HDACS DEACETYLATE HISTONES 47 9.95e-01 9.96e-01 0.00695 1.97e-03 -0.006670 9.81e-01 9.37e-01
DEUBIQUITINATION 241 9.96e-01 9.96e-01 0.00291 2.80e-03 -0.000789 9.40e-01 9.83e-01


Detailed Gene set reports


EUKARYOTIC TRANSLATION ELONGATION
EUKARYOTIC TRANSLATION ELONGATION
metric value
setSize 87
pMANOVA 3.42e-33
p.adjustMANOVA 2.01e-30
s.dist 0.815
s.LPS 0.301
s.OVA 0.757
p.LPS 1.28e-06
p.OVA 2.23e-34



Top 20 genes
Gene LPS OVA
Eef1d 7466 7064
Rpl8 6585 7422
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Rpl36 5913 7633
Rpl13 6166 7175
Rps20 5501 7928
Rpsa 5435 7739
Eef1b2 6050 6897
Rplp1 5261 7625
Fau 5367 7429
Rplp2 4991 7649
Rpl19 5546 6847
Rps15 5393 6985
Rps8 4983 7371

Click HERE to show all gene set members

All member genes
LPS OVA
Eef1a1 4371 6243
Eef1a2 4093 -4811
Eef1b2 6050 6897
Eef1d 7466 7064
Eef1g 985 5648
Eef2 5786 4599
Fau 5367 7429
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Uba52 4573 7321



SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
metric value
setSize 106
pMANOVA 2.33e-32
p.adjustMANOVA 9.14e-30
s.dist 0.723
s.LPS 0.254
s.OVA 0.677
p.LPS 6.23e-06
p.OVA 1.67e-33



Top 20 genes
Gene LPS OVA
Rpl8 6585 7422
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Rpl36 5913 7633
Rpl13 6166 7175
Rps20 5501 7928
Sec61g 5282 8012
Rpsa 5435 7739
Ssr4 6356 6476
Rplp1 5261 7625
Fau 5367 7429
Sec61b 5178 7543
Rplp2 4991 7649
Rpl19 5546 6847
Rps15 5393 6985

Click HERE to show all gene set members

All member genes
LPS OVA
Ddost 6409 2866
Fau 5367 7429
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rpn1 4997 3395
Rpn2 6176 5526
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Sec11a -216 2994
Sec11c -1020 5409
Sec61a1 4890 505
Sec61a2 -5000 -5427
Sec61b 5178 7543
Sec61g 5282 8012
Spcs1 2563 7606
Spcs2 -344 4906
Spcs3 -8166 -1009
Srp14 2204 2658
Srp19 390 5880
Srp54a -6107 2529
Srp68 6255 157
Srp72 4189 -1834
Srp9 -3616 4163
Srpr 6466 63
Srprb 5692 -3733
Ssr1 -4519 -1071
Ssr2 4437 4809
Ssr3 -3654 7761
Ssr4 6356 6476
Tram1 -5657 6723
Uba52 4573 7321



RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
metric value
setSize 95
pMANOVA 3.32e-27
p.adjustMANOVA 7.79e-25
s.dist 0.69
s.LPS 0.222
s.OVA 0.653
p.LPS 0.000182
p.OVA 3.29e-28



Top 20 genes
Gene LPS OVA
Rpl8 6585 7422
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Rpl36 5913 7633
Rpl13 6166 7175
Rps20 5501 7928
Rpsa 5435 7739
Rplp1 5261 7625
Fau 5367 7429
Rplp2 4991 7649
Rpl19 5546 6847
Rps15 5393 6985
Rps8 4983 7371
Rps15a 5456 6416
Uba52 4573 7321

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -4365 -6331
Atf2 -7621 -6211
Atf3 6753 1500
Atf4 5387 -534
Cebpb 6325 -2815
Cebpg -6991 -978
Ddit3 4291 4052
Eif2ak4 -4316 -7310
Eif2s1 -5543 -2135
Eif2s2 -5715 3812
Eif2s3x -3701 3844
Fau 5367 7429
Gcn1 5004 1949
Impact -486 2349
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Trib3 -3573 2810
Uba52 4573 7321



REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
metric value
setSize 10
pMANOVA 0.00291
p.adjustMANOVA 0.0209
s.dist 0.676
s.LPS -0.26
s.OVA -0.624
p.LPS 0.155
p.OVA 0.000632



Top 20 genes
Gene LPS OVA
Robo2 -8122 -5143
Robo3 -6656 -5945
Ntn1 -5680 -4855
Robo1 -7726 -3154
Dcc -8429 -1796

Click HERE to show all gene set members

All member genes
LPS OVA
Dcc -8429 -1796
Nell2 4072 -7487
Ntn1 -5680 -4855
Robo1 -7726 -3154
Robo2 -8122 -5143
Robo3 -6656 -5945
Slit1 3447 -6943
Slit2 210 -4660
Slit3 1773 -7271
Src 4054 -4491



EUKARYOTIC TRANSLATION INITIATION
EUKARYOTIC TRANSLATION INITIATION
metric value
setSize 114
pMANOVA 1.91e-30
p.adjustMANOVA 5.61e-28
s.dist 0.663
s.LPS 0.204
s.OVA 0.631
p.LPS 0.000164
p.OVA 2.28e-31



Top 20 genes
Gene LPS OVA
Eif4a1 7428 7715
Eif3b 7633 7180
Rpl8 6585 7422
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Rpl36 5913 7633
Rpl13 6166 7175
Rps20 5501 7928
Rpsa 5435 7739
Eif3l 6344 6596
Eif2b5 6354 6434
Rplp1 5261 7625
Eif3f 4929 8100
Fau 5367 7429
Eif3d 7020 5543

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7793 -5142
Eif2b1 -1745 -5602
Eif2b2 7707 1152
Eif2b3 -3476 452
Eif2b4 4726 5762
Eif2b5 6354 6434
Eif2s1 -5543 -2135
Eif2s2 -5715 3812
Eif2s3x -3701 3844
Eif3a 192 -5791
Eif3b 7633 7180
Eif3c 3170 407
Eif3d 7020 5543
Eif3e -7457 5707
Eif3f 4929 8100
Eif3g 5108 2047
Eif3h 5018 4170
Eif3i 6161 5376
Eif3j1 -5830 481
Eif3j2 -5550 7555
Eif3k 4251 5012
Eif3l 6344 6596
Eif3m -3388 6058
Eif4a1 7428 7715
Eif4a2 -7772 -2030
Eif4b -1945 -2667
Eif4e -563 3694
Eif4ebp1 -3320 4471
Eif4g1 5030 -2226
Eif4h 4881 -21
Eif5 -7861 -3706
Eif5b -5791 991
Fau 5367 7429
Pabpc1 -6868 5519
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Uba52 4573 7321



REDUCTION OF CYTOSOLIC CA LEVELS
REDUCTION OF CYTOSOLIC CA LEVELS
metric value
setSize 11
pMANOVA 0.00474
p.adjustMANOVA 0.0308
s.dist 0.65
s.LPS -0.557
s.OVA -0.336
p.LPS 0.00138
p.OVA 0.0539



Top 20 genes
Gene LPS OVA
Atp2a3 -7120 -7766
Atp2b4 -7729 -4942
Atp2b1 -8469 -2698
Atp2a2 -4255 -2767
Atp2b2 -6916 -1258
Atp2b3 -1350 -4164
Slc8a1 -8170 -122

Click HERE to show all gene set members

All member genes
LPS OVA
Atp2a2 -4255 -2767
Atp2a3 -7120 -7766
Atp2b1 -8469 -2698
Atp2b2 -6916 -1258
Atp2b3 -1350 -4164
Atp2b4 -7729 -4942
Calm1 -7890 1510
Slc8a1 -8170 -122
Slc8a2 4127 -6848
Slc8a3 1450 -6022
Sri -6756 5039



YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
metric value
setSize 11
pMANOVA 0.00151
p.adjustMANOVA 0.0127
s.dist 0.633
s.LPS 0.144
s.OVA 0.616
p.LPS 0.408
p.OVA 0.000399



Top 20 genes
Gene LPS OVA
Tead2 8234 8286
Ccn2 7629 8087
Yap1 6444 8501
Tead1 2646 7591
Tead3 3965 2129
Runx2 517 3047

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All member genes
LPS OVA
Ccn2 7629 8087
Hipk1 -4118 1115
Hipk2 -2628 6373
Kat2b -4287 3856
Nppa -1229 3382
Runx2 517 3047
Tead1 2646 7591
Tead2 8234 8286
Tead3 3965 2129
Wwtr1 -4913 6337
Yap1 6444 8501



POST CHAPERONIN TUBULIN FOLDING PATHWAY
POST CHAPERONIN TUBULIN FOLDING PATHWAY
metric value
setSize 17
pMANOVA 5.32e-06
p.adjustMANOVA 0.00013
s.dist 0.629
s.LPS 0.629
s.OVA -0.00377
p.LPS 7.12e-06
p.OVA 0.979



Top 20 genes
Gene LPS OVA
Tubb4a 7131 -5164
Tubb3 7161 -4852
Tuba8 4699 -6670
Tuba4a 5111 -5124
Tbcc 2426 -4429
Tubb2b 6404 -908
Tbcd 5001 -585
Arl2 6273 -296

Click HERE to show all gene set members

All member genes
LPS OVA
Arl2 6273 -296
Tbca -1003 5744
Tbcb 6927 3404
Tbcc 2426 -4429
Tbcd 5001 -585
Tbce -3112 -7030
Tuba1a 7803 6915
Tuba1b 7786 6590
Tuba1c 2927 6642
Tuba4a 5111 -5124
Tuba8 4699 -6670
Tubb2a 7932 1277
Tubb2b 6404 -908
Tubb3 7161 -4852
Tubb4a 7131 -5164
Tubb4b 7939 1029
Tubb6 7355 4843



SELENOAMINO ACID METABOLISM
SELENOAMINO ACID METABOLISM
metric value
setSize 109
pMANOVA 1.35e-24
p.adjustMANOVA 2.27e-22
s.dist 0.629
s.LPS 0.241
s.OVA 0.581
p.LPS 1.42e-05
p.OVA 1.02e-25



Top 20 genes
Gene LPS OVA
Rpl8 6585 7422
Aimp2 6191 7845
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Ahcy 5635 8423
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Rpl36 5913 7633
Rpl13 6166 7175
Rps20 5501 7928
Rpsa 5435 7739
Qars 5806 7196
Rplp1 5261 7625
Fau 5367 7429
Rplp2 4991 7649
Rpl19 5546 6847
Rps15 5393 6985

Click HERE to show all gene set members

All member genes
LPS OVA
Ahcy 5635 8423
Aimp1 4742 6219
Aimp2 6191 7845
Cbs -350 1295
Cth -3516 7159
Dars -6594 -5526
Eef1e1 5007 5633
Eefsec 5826 735
Eprs -7826 -4236
Fau 5367 7429
Gnmt 274 -3920
Gsr -5443 1981
Hnmt -8497 -2904
Iars -1516 -7685
Kars 2956 1022
Lars -6729 -4563
Mars1 7772 -3073
Nnmt 4723 7153
Papss1 2904 2371
Papss2 -520 2945
Pstk 5554 6003
Qars 5806 7196
Rars -12 -3127
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Sars 1048 -8012
Scly 7581 -2831
Secisbp2 727 -7346
Sephs2 6329 4880
Sepsecs -6994 -6724
Txnrd1 1934 -5166
Uba52 4573 7321



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 6.42e-05
p.adjustMANOVA 0.00101
s.dist 0.614
s.LPS 0.581
s.OVA 0.199
p.LPS 1.17e-05
p.OVA 0.132



Top 20 genes
Gene LPS OVA
Tuba1a 7803 6915
Cct3 7150 7329
Tuba1b 7786 6590
Tubb6 7355 4843
Cct5 7868 4492
Cct7 7182 4062
Cct4 3768 7333
Tuba1c 2927 6642
Tubb2a 7932 1277
Tubb4b 7939 1029
Cct2 615 4096

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All member genes
LPS OVA
Cct2 615 4096
Cct3 7150 7329
Cct4 3768 7333
Cct5 7868 4492
Cct6a -2044 1882
Cct7 7182 4062
Cct8 -2171 -1209
Tcp1 -3171 1675
Tuba1a 7803 6915
Tuba1b 7786 6590
Tuba1c 2927 6642
Tuba4a 5111 -5124
Tuba8 4699 -6670
Tubb2a 7932 1277
Tubb2b 6404 -908
Tubb3 7161 -4852
Tubb4a 7131 -5164
Tubb4b 7939 1029
Tubb6 7355 4843



ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
metric value
setSize 59
pMANOVA 3.21e-14
p.adjustMANOVA 2.52e-12
s.dist 0.609
s.LPS 0.162
s.OVA 0.587
p.LPS 0.0314
p.OVA 6.06e-15



Top 20 genes
Gene LPS OVA
Eif4a1 7428 7715
Eif3b 7633 7180
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rps21 5711 8072
Rps28 5823 7818
Rps20 5501 7928
Rpsa 5435 7739
Eif3l 6344 6596
Eif3f 4929 8100
Fau 5367 7429
Eif3d 7020 5543
Rps15 5393 6985
Rps8 4983 7371
Rps15a 5456 6416
Eif3i 6161 5376
Rps10 4340 7198
Rps9 4136 7518
Rps19 3727 7799

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7793 -5142
Eif2s1 -5543 -2135
Eif2s2 -5715 3812
Eif2s3x -3701 3844
Eif3a 192 -5791
Eif3b 7633 7180
Eif3c 3170 407
Eif3d 7020 5543
Eif3e -7457 5707
Eif3f 4929 8100
Eif3g 5108 2047
Eif3h 5018 4170
Eif3i 6161 5376
Eif3j1 -5830 481
Eif3j2 -5550 7555
Eif3k 4251 5012
Eif3l 6344 6596
Eif3m -3388 6058
Eif4a1 7428 7715
Eif4a2 -7772 -2030
Eif4b -1945 -2667
Eif4e -563 3694
Eif4ebp1 -3320 4471
Eif4g1 5030 -2226
Eif4h 4881 -21
Fau 5367 7429
Pabpc1 -6868 5519
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739



CGMP EFFECTS
CGMP EFFECTS
metric value
setSize 15
pMANOVA 0.000801
p.adjustMANOVA 0.00798
s.dist 0.604
s.LPS -0.563
s.OVA -0.22
p.LPS 0.00016
p.OVA 0.141



Top 20 genes
Gene LPS OVA
Kcnmb2 -8570 -8258
Pde1b -8151 -6567
Prkg1 -5062 -7917
Pde11a -3875 -7537
Kcnma1 -7254 -3511
Pde10a -8088 -2423
Pde1a -7925 -2302
Itpr1 -7360 -2193
Pde2a -7401 -2154

Click HERE to show all gene set members

All member genes
LPS OVA
Irag1 -1224 4224
Itpr1 -7360 -2193
Kcnma1 -7254 -3511
Kcnmb1 4516 -5126
Kcnmb2 -8570 -8258
Kcnmb4 -3807 7808
Pde10a -8088 -2423
Pde11a -3875 -7537
Pde1a -7925 -2302
Pde1b -8151 -6567
Pde2a -7401 -2154
Pde5a -6711 5759
Pde9a 2571 3716
Prkg1 -5062 -7917
Prkg2 -4773 261



TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
metric value
setSize 13
pMANOVA 0.000783
p.adjustMANOVA 0.00787
s.dist 0.604
s.LPS 0.592
s.OVA 0.122
p.LPS 0.000221
p.OVA 0.447



Top 20 genes
Gene LPS OVA
Tuba1a 7803 6915
Tuba1b 7786 6590
Tubb6 7355 4843
Tuba1c 2927 6642
Tubb2a 7932 1277
Tubb4b 7939 1029

Click HERE to show all gene set members

All member genes
LPS OVA
Gja1 -4277 5556
Gjb2 -4194 4748
Tuba1a 7803 6915
Tuba1b 7786 6590
Tuba1c 2927 6642
Tuba4a 5111 -5124
Tuba8 4699 -6670
Tubb2a 7932 1277
Tubb2b 6404 -908
Tubb3 7161 -4852
Tubb4a 7131 -5164
Tubb4b 7939 1029
Tubb6 7355 4843



P75NTR REGULATES AXONOGENESIS
P75NTR REGULATES AXONOGENESIS
metric value
setSize 10
pMANOVA 0.0197
p.adjustMANOVA 0.0917
s.dist 0.592
s.LPS -0.492
s.OVA -0.33
p.LPS 0.00707
p.OVA 0.0709



Top 20 genes
Gene LPS OVA
Mcf2 -7930 -7910
Rtn4r -6151 -8059
Omg -7255 -6690
Rtn4 -7610 -4565
Mag -4610 -4677
Lingo1 -2603 -8222
Ngfr -6637 -237

Click HERE to show all gene set members

All member genes
LPS OVA
Arhgdia 8053 5850
Lingo1 -2603 -8222
Mag -4610 -4677
Mcf2 -7930 -7910
Ngf -4905 1227
Ngfr -6637 -237
Omg -7255 -6690
Rhoa -3083 6472
Rtn4 -7610 -4565
Rtn4r -6151 -8059



ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
metric value
setSize 10
pMANOVA 0.0104
p.adjustMANOVA 0.0581
s.dist 0.587
s.LPS -0.202
s.OVA -0.551
p.LPS 0.269
p.OVA 0.00255



Top 20 genes
Gene LPS OVA
Mapk8 -8250 -7436
Atf2 -7621 -6211
Mapk10 -4335 -6173
Mapk9 -3955 -5741
Mapk1 -8326 -2421
Fos -1388 -7856

Click HERE to show all gene set members

All member genes
LPS OVA
Atf2 -7621 -6211
Fos -1388 -7856
Jun 3927 -7568
Mapk1 -8326 -2421
Mapk10 -4335 -6173
Mapk11 5281 -4752
Mapk14 1862 -1635
Mapk3 4628 4232
Mapk8 -8250 -7436
Mapk9 -3955 -5741



NEUROTOXICITY OF CLOSTRIDIUM TOXINS
NEUROTOXICITY OF CLOSTRIDIUM TOXINS
metric value
setSize 10
pMANOVA 0.0248
p.adjustMANOVA 0.106
s.dist 0.586
s.LPS -0.376
s.OVA -0.45
p.LPS 0.0396
p.OVA 0.0138



Top 20 genes
Gene LPS OVA
Snap25 -8522 -7928
Syt1 -8572 -6696
Sv2b -8103 -7008
Syt2 -7580 -2642
Vamp1 -1062 -5103
Sv2c -3780 -950

Click HERE to show all gene set members

All member genes
LPS OVA
Snap25 -8522 -7928
Stx1a 7210 -4499
Stx1b 399 -5783
Sv2a 627 -3036
Sv2b -8103 -7008
Sv2c -3780 -950
Syt1 -8572 -6696
Syt2 -7580 -2642
Vamp1 -1062 -5103
Vamp2 -3510 6677



HDR THROUGH MMEJ ALT NHEJ
HDR THROUGH MMEJ ALT NHEJ
metric value
setSize 10
pMANOVA 0.0287
p.adjustMANOVA 0.118
s.dist 0.572
s.LPS -0.355
s.OVA -0.449
p.LPS 0.0519
p.OVA 0.014



Top 20 genes
Gene LPS OVA
Rad50 -8453 -7854
Rbbp8 -6149 -8263
Nbn -5713 -7264
Parp1 -5171 -7467
Parp2 -3984 -4718
Lig3 -2782 -2422

Click HERE to show all gene set members

All member genes
LPS OVA
Fen1 408 -7126
Lig3 -2782 -2422
Mre11a -2936 129
Nbn -5713 -7264
Parp1 -5171 -7467
Parp2 -3984 -4718
Polq -3555 363
Rad50 -8453 -7854
Rbbp8 -6149 -8263
Xrcc1 7201 7743



ENDOSOMAL VACUOLAR PATHWAY
ENDOSOMAL VACUOLAR PATHWAY
metric value
setSize 11
pMANOVA 0.000192
p.adjustMANOVA 0.0024
s.dist 0.567
s.LPS -0.276
s.OVA 0.496
p.LPS 0.113
p.OVA 0.00443



Top 20 genes
Gene LPS OVA
B2m -7816 6591
H2-T23 -7622 5175
H2-Q7 -5372 6482
H2-D1 -5196 4710
Lnpep -5806 2486
Ctss -3154 2934
H2-Q2 -533 5287

Click HERE to show all gene set members

All member genes
LPS OVA
B2m -7816 6591
Ctsl 3422 4915
Ctss -3154 2934
H2-Bl 4709 4767
H2-D1 -5196 4710
H2-M3 -2356 -246
H2-Q10 2867 4332
H2-Q2 -533 5287
H2-Q7 -5372 6482
H2-T23 -7622 5175
Lnpep -5806 2486



CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS
metric value
setSize 12
pMANOVA 0.00863
p.adjustMANOVA 0.0495
s.dist 0.564
s.LPS -0.234
s.OVA -0.513
p.LPS 0.16
p.OVA 0.00208



Top 20 genes
Gene LPS OVA
Gabbr2 -4117 -7998
Grm5 -8314 -2782
Casr -3659 -5376
Grm2 -2374 -8185
Grm1 -7416 -2613
Grm3 -8339 -2099
Grm4 -1690 -7337

Click HERE to show all gene set members

All member genes
LPS OVA
Casr -3659 -5376
Gabbr1 2237 -3143
Gabbr2 -4117 -7998
Grm1 -7416 -2613
Grm2 -2374 -8185
Grm3 -8339 -2099
Grm4 -1690 -7337
Grm5 -8314 -2782
Grm7 824 -6617
Grm8 3850 -4638
Tas1r1 6258 -1392
Tas1r3 -2354 1366



NONSENSE MEDIATED DECAY NMD
NONSENSE MEDIATED DECAY NMD
metric value
setSize 109
pMANOVA 1.73e-20
p.adjustMANOVA 2.25e-18
s.dist 0.564
s.LPS 0.197
s.OVA 0.528
p.LPS 0.000376
p.OVA 1.52e-21



Top 20 genes
Gene LPS OVA
Rpl8 6585 7422
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Rpl36 5913 7633
Rpl13 6166 7175
Rps20 5501 7928
Rpsa 5435 7739
Rplp1 5261 7625
Fau 5367 7429
Rplp2 4991 7649
Rpl19 5546 6847
Rps15 5393 6985
Rps8 4983 7371
Rps15a 5456 6416
Uba52 4573 7321

Click HERE to show all gene set members

All member genes
LPS OVA
Casc3 572 -3997
Dcp1a -4545 -5062
Eif4a3 3538 3512
Eif4g1 5030 -2226
Etf1 -5324 -5319
Fau 5367 7429
Gspt1 -966 -2334
Gspt2 2513 -4743
Magoh 1335 7733
Magohb -2575 -6704
Ncbp1 4081 6645
Ncbp2 -6150 -5246
Pabpc1 -6868 5519
Pnrc2 -5200 5174
Ppp2ca 2977 -2704
Ppp2r1a 1738 -4348
Ppp2r2a -7275 -5270
Rbm8a -997 6211
Rnps1 -2825 -2013
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Smg1 -3251 275
Smg5 6955 -3880
Smg6 -1047 -6603
Smg7 -7207 -285
Smg8 -1909 -5228
Smg9 4687 -6747
Uba52 4573 7321
Upf1 6015 -2726
Upf2 3281 -51
Upf3a 389 -1437
Upf3b 82 -601



FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
metric value
setSize 18
pMANOVA 0.000261
p.adjustMANOVA 0.00306
s.dist 0.557
s.LPS 0.125
s.OVA 0.543
p.LPS 0.358
p.OVA 6.65e-05



Top 20 genes
Gene LPS OVA
Atp5k 5706 7128
mt-Atp8 4024 7998
Atp5d 5782 5289
Atp5e 2735 7349
Atp5g1 5286 3351
Atp5g2 1393 8352
Atp5l 1542 6454
Atp5j2 2054 3874
Atp5b 2737 2753
Atp5j 1202 3834
Atp5g3 552 5969
Atp5h 188 6232
Atp5a1 264 3481
Atp5o 1967 98

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All member genes
LPS OVA
Atp5a1 264 3481
Atp5b 2737 2753
Atp5c1 -2591 3513
Atp5d 5782 5289
Atp5e 2735 7349
Atp5g1 5286 3351
Atp5g2 1393 8352
Atp5g3 552 5969
Atp5h 188 6232
Atp5j 1202 3834
Atp5j2 2054 3874
Atp5k 5706 7128
Atp5l 1542 6454
Atp5o 1967 98
Atp5pb -2002 823
Dmac2l -6808 1963
mt-Atp6 -6870 6350
mt-Atp8 4024 7998



COMPLEX I BIOGENESIS
COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 1.08e-10
p.adjustMANOVA 6.36e-09
s.dist 0.557
s.LPS 0.191
s.OVA 0.523
p.LPS 0.0133
p.OVA 1.31e-11



Top 20 genes
Gene LPS OVA
Ndufa2 6084 7875
Ndufaf6 7697 5974
Timmdc1 6640 6660
Ndufb2 5640 7622
Ndufb10 5856 6670
Ndufv1 5257 6551
Ndufaf5 4554 7307
Ndufaf3 7585 4364
Ndufa1 4522 7212
Ndufb1 4995 6470
Ndufa6 5426 5703
Ecsit 4980 6204
Ndufs5 5544 5354
Ndufa13 5502 5339
Ndufb8 4884 5973
Ndufs7 7071 4108
Ndufb11 4314 6610
Ndufb7 5169 4927
Ndufa11 4909 5113
Ndufa7 4012 5896

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All member genes
LPS OVA
Acad9 7184 -238
Ecsit 4980 6204
mt-Nd1 -6354 6107
mt-Nd2 -5139 6601
mt-Nd3 -6174 7841
mt-Nd4 -6828 6611
mt-Nd5 -6424 6942
mt-Nd6 -4602 7427
Ndufa1 4522 7212
Ndufa10 -1599 -3057
Ndufa11 4909 5113
Ndufa12 898 3636
Ndufa13 5502 5339
Ndufa2 6084 7875
Ndufa3 3719 5991
Ndufa5 -426 5104
Ndufa6 5426 5703
Ndufa7 4012 5896
Ndufa8 2460 3276
Ndufa9 -4162 883
Ndufab1 4221 5489
Ndufaf1 -3804 6803
Ndufaf2 -5654 1337
Ndufaf3 7585 4364
Ndufaf4 -5981 -1991
Ndufaf5 4554 7307
Ndufaf6 7697 5974
Ndufaf7 2507 6594
Ndufb1 4995 6470
Ndufb10 5856 6670
Ndufb11 4314 6610
Ndufb2 5640 7622
Ndufb3 -730 2044
Ndufb4 -1297 5820
Ndufb5 -603 4684
Ndufb6 731 4755
Ndufb7 5169 4927
Ndufb8 4884 5973
Ndufb9 -303 6512
Ndufc1 244 5855
Ndufc2 1754 5872
Ndufs1 -4604 -3894
Ndufs2 3053 3752
Ndufs3 2654 7122
Ndufs4 -4324 3535
Ndufs5 5544 5354
Ndufs6 2864 6189
Ndufs7 7071 4108
Ndufs8 6562 3004
Ndufv1 5257 6551
Ndufv2 -2332 2393
Ndufv3 1679 3060
Nubpl -2947 3902
Timmdc1 6640 6660
Tmem126b 4955 -1178
Tmem186 2756 -7026



NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
metric value
setSize 20
pMANOVA 0.000335
p.adjustMANOVA 0.00382
s.dist 0.553
s.LPS -0.516
s.OVA -0.198
p.LPS 6.36e-05
p.OVA 0.125



Top 20 genes
Gene LPS OVA
Kcnmb2 -8570 -8258
Gucy1a1 -8528 -7761
Pde1b -8151 -6567
Prkg1 -5062 -7917
Gucy1b1 -6877 -4613
Pde11a -3875 -7537
Kcnma1 -7254 -3511
Pde10a -8088 -2423
Pde1a -7925 -2302
Itpr1 -7360 -2193
Pde2a -7401 -2154

Click HERE to show all gene set members

All member genes
LPS OVA
Gucy1a1 -8528 -7761
Gucy1a2 -5548 3482
Gucy1b1 -6877 -4613
Irag1 -1224 4224
Itpr1 -7360 -2193
Kcnma1 -7254 -3511
Kcnmb1 4516 -5126
Kcnmb2 -8570 -8258
Kcnmb4 -3807 7808
Nos1 2769 -3145
Nos3 1714 6975
Pde10a -8088 -2423
Pde11a -3875 -7537
Pde1a -7925 -2302
Pde1b -8151 -6567
Pde2a -7401 -2154
Pde5a -6711 5759
Pde9a 2571 3716
Prkg1 -5062 -7917
Prkg2 -4773 261



VOLTAGE GATED POTASSIUM CHANNELS
VOLTAGE GATED POTASSIUM CHANNELS
metric value
setSize 39
pMANOVA 5.74e-06
p.adjustMANOVA 0.000138
s.dist 0.538
s.LPS -0.399
s.OVA -0.361
p.LPS 1.59e-05
p.OVA 9.64e-05



Top 20 genes
Gene LPS OVA
Kcnq1 -7263 -8331
Kcns1 -8367 -6884
Kcnh7 -8498 -6446
Kcna2 -8511 -5464
Kcnq5 -7965 -5767
Kcng1 -7705 -5306
Kcnd1 -4842 -7825
Kcnab3 -7659 -4924
Kcns2 -4919 -7664
Kcnf1 -4977 -7260
Kcna4 -5256 -6588
Kcnd3 -7415 -4036
Kcna6 -3944 -6500
Kcnb1 -3791 -5492
Kcnd2 -6961 -2441
Kcng4 -2528 -6643
Kcnq3 -7809 -1436
Kcnc1 -2096 -4858
Kcnv1 -7953 -1262
Kcnq2 -2004 -4584

Click HERE to show all gene set members

All member genes
LPS OVA
Kcna1 -6270 2031
Kcna2 -8511 -5464
Kcna3 -577 -1077
Kcna4 -5256 -6588
Kcna5 801 -545
Kcna6 -3944 -6500
Kcnab1 -8308 546
Kcnab2 -427 -4062
Kcnab3 -7659 -4924
Kcnb1 -3791 -5492
Kcnb2 -5909 1535
Kcnc1 -2096 -4858
Kcnc2 -7507 1715
Kcnc3 1701 1419
Kcnc4 4331 -5969
Kcnd1 -4842 -7825
Kcnd2 -6961 -2441
Kcnd3 -7415 -4036
Kcnf1 -4977 -7260
Kcng1 -7705 -5306
Kcng2 3942 -2358
Kcng4 -2528 -6643
Kcnh1 -2670 -1944
Kcnh2 3346 -3713
Kcnh3 -6946 228
Kcnh4 -1505 -1049
Kcnh5 -5290 -317
Kcnh6 5674 -35
Kcnh7 -8498 -6446
Kcnh8 106 1846
Kcnq1 -7263 -8331
Kcnq2 -2004 -4584
Kcnq3 -7809 -1436
Kcnq4 2696 -776
Kcnq5 -7965 -5767
Kcns1 -8367 -6884
Kcns2 -4919 -7664
Kcns3 7397 7619
Kcnv1 -7953 -1262



APOPTOSIS INDUCED DNA FRAGMENTATION
APOPTOSIS INDUCED DNA FRAGMENTATION
metric value
setSize 10
pMANOVA 0.0334
p.adjustMANOVA 0.132
s.dist 0.529
s.LPS -0.474
s.OVA -0.235
p.LPS 0.00944
p.OVA 0.198



Top 20 genes
Gene LPS OVA
H1f0 -8541 -8338
H1f2 -8562 -2744
Kpnb1 -1904 -3386
H1f4 -2594 -2483
Dffb -1318 -4368
Casp3 -2337 -1373

Click HERE to show all gene set members

All member genes
LPS OVA
Casp3 -2337 -1373
Dffa 3168 -6157
Dffb -1318 -4368
H1f0 -8541 -8338
H1f2 -8562 -2744
H1f4 -2594 -2483
Hmgb1 -7078 5779
Hmgb2 -5767 3186
Kpna1 -6286 1096
Kpnb1 -1904 -3386



CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
metric value
setSize 46
pMANOVA 8.34e-07
p.adjustMANOVA 3.09e-05
s.dist 0.529
s.LPS 0.324
s.OVA 0.418
p.LPS 0.000145
p.OVA 9.15e-07



Top 20 genes
Gene LPS OVA
Psmd3 7906 6875
Psmd13 7257 6935
Sem1 6780 7134
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6135
Psmb2 6181 7347
Psme2 5471 8074
Psmb4 6894 6171
Psmc3 6685 6182
Mrc2 6977 5912
Psmc5 6075 6613
Psmd10 5799 6777
Psmb6 6328 5606
Psme1 7334 4530
Psmd8 5319 6063
Psmb7 4529 6188
Psmb10 4825 5736
Psmb1 4456 5798
Psmd4 6593 3490

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All member genes
LPS OVA
Fcgr1 -4209 1931
Mrc1 -3316 -3869
Mrc2 6977 5912
Psma1 -841 5990
Psma2 4139 4580
Psma3 -1200 7148
Psma4 -129 1874
Psma5 5707 3544
Psma6 2309 4521
Psma7 4000 4639
Psmb1 4456 5798
Psmb10 4825 5736
Psmb2 6181 7347
Psmb3 3566 5508
Psmb4 6894 6171
Psmb5 7413 6135
Psmb6 6328 5606
Psmb7 4529 6188
Psmb8 -6836 3642
Psmb9 -7424 903
Psmc1 -2672 1371
Psmc2 4816 429
Psmc3 6685 6182
Psmc4 8055 5833
Psmc5 6075 6613
Psmc6 -5042 -5237
Psmd1 1230 -2032
Psmd10 5799 6777
Psmd11 -2334 825
Psmd12 -4520 -7821
Psmd13 7257 6935
Psmd14 137 6700
Psmd2 4201 -917
Psmd3 7906 6875
Psmd4 6593 3490
Psmd5 1735 -1276
Psmd6 2251 5121
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3349 6664
Psme1 7334 4530
Psme2 5471 8074
Psme3 -86 3241
Psme4 -5574 -2402
Psmf1 -1095 -378
Sem1 6780 7134



SEROTONIN NEUROTRANSMITTER RELEASE CYCLE
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE
metric value
setSize 18
pMANOVA 0.000957
p.adjustMANOVA 0.00902
s.dist 0.528
s.LPS -0.155
s.OVA -0.505
p.LPS 0.254
p.OVA 0.00021



Top 20 genes
Gene LPS OVA
Snap25 -8522 -7928
Syt1 -8572 -6696
Ppfia2 -6854 -5991
Cplx1 -8022 -3532
Rims1 -7558 -3741
Syn3 -5846 -3671
Ppfia1 -4172 -4797
Syn1 -1022 -6788
Stxbp1 -254 -6826
Tspoap1 -272 -4672

Click HERE to show all gene set members

All member genes
LPS OVA
Cplx1 -8022 -3532
Ppfia1 -4172 -4797
Ppfia2 -6854 -5991
Ppfia3 7570 -155
Ppfia4 7531 -1753
Rab3a 4343 -4180
Rims1 -7558 -3741
Slc18a2 809 -7291
Snap25 -8522 -7928
Stx1a 7210 -4499
Stxbp1 -254 -6826
Syn1 -1022 -6788
Syn2 1079 -5120
Syn3 -5846 -3671
Syt1 -8572 -6696
Tspoap1 -272 -4672
Unc13b 507 -3922
Vamp2 -3510 6677



KERATAN SULFATE DEGRADATION
KERATAN SULFATE DEGRADATION
metric value
setSize 12
pMANOVA 0.0281
p.adjustMANOVA 0.117
s.dist 0.524
s.LPS 0.326
s.OVA 0.41
p.LPS 0.0502
p.OVA 0.0139



Top 20 genes
Gene LPS OVA
Prelp 6526 7869
Lum 5854 7973
Hexa 7151 6503
Fmod 5939 7486
Galns 5020 5258
Omd 2837 5484
Glb1l 3591 4275

Click HERE to show all gene set members

All member genes
LPS OVA
Acan -3718 -8349
Fmod 5939 7486
Galns 5020 5258
Glb1 2428 -4179
Glb1l 3591 4275
Gns 2335 -2317
Hexa 7151 6503
Hexb -5604 6092
Lum 5854 7973
Ogn -438 6954
Omd 2837 5484
Prelp 6526 7869



SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
metric value
setSize 23
pMANOVA 7.54e-05
p.adjustMANOVA 0.00114
s.dist 0.523
s.LPS 0.512
s.OVA 0.104
p.LPS 2.12e-05
p.OVA 0.388



Top 20 genes
Gene LPS OVA
Lemd2 8238 7578
Tuba1a 7803 6915
Tuba1b 7786 6590
Chmp4b 7509 5298
Tubb6 7355 4843
Chmp2a 3770 5951
Tuba1c 2927 6642
Tubb2a 7932 1277
Tubb4b 7939 1029

Click HERE to show all gene set members

All member genes
LPS OVA
Cc2d1b 4195 -1798
Chmp2a 3770 5951
Chmp2b -8286 3363
Chmp3 -110 -3608
Chmp4b 7509 5298
Chmp4c -2082 7791
Chmp6 6102 -1183
Chmp7 6767 -3466
Ist1 -1812 3579
Lemd2 8238 7578
Spast -3692 -2569
Tuba1a 7803 6915
Tuba1b 7786 6590
Tuba1c 2927 6642
Tuba4a 5111 -5124
Tuba8 4699 -6670
Tubb2a 7932 1277
Tubb2b 6404 -908
Tubb3 7161 -4852
Tubb4a 7131 -5164
Tubb4b 7939 1029
Tubb6 7355 4843
Vps4a 4462 -2640



REGULATION OF EXPRESSION OF SLITS AND ROBOS
REGULATION OF EXPRESSION OF SLITS AND ROBOS
metric value
setSize 160
pMANOVA 4.23e-24
p.adjustMANOVA 6.21e-22
s.dist 0.521
s.LPS 0.216
s.OVA 0.474
p.LPS 2.42e-06
p.OVA 3.75e-25



Top 20 genes
Gene LPS OVA
Psmd3 7906 6875
Psmd13 7257 6935
Rpl8 6585 7422
Sem1 6780 7134
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Psmd7 8072 5831
Psmc4 8055 5833
Rpl38 5942 7800
Rps21 5711 8072
Rps28 5823 7818
Psmb5 7413 6135
Psmb2 6181 7347
Rpl36 5913 7633
Rpl13 6166 7175
Psme2 5471 8074
Rps20 5501 7928
Psmb4 6894 6171

Click HERE to show all gene set members

All member genes
LPS OVA
Casc3 572 -3997
Col4a5 4065 2459
Cul2 -3999 -3753
Dag1 -836 925
Eif4a3 3538 3512
Eif4g1 5030 -2226
Elob 6245 6316
Eloc -8237 1090
Etf1 -5324 -5319
Fau 5367 7429
Gspt1 -966 -2334
Gspt2 2513 -4743
Isl1 3922 5940
Ldb1 -858 -2521
Lhx2 -6783 -4659
Lhx9 -5708 -6241
Magoh 1335 7733
Magohb -2575 -6704
Msi1 -1012 -3979
Ncbp1 4081 6645
Ncbp2 -6150 -5246
Pabpc1 -6868 5519
Psma1 -841 5990
Psma2 4139 4580
Psma3 -1200 7148
Psma4 -129 1874
Psma5 5707 3544
Psma6 2309 4521
Psma7 4000 4639
Psmb1 4456 5798
Psmb10 4825 5736
Psmb2 6181 7347
Psmb3 3566 5508
Psmb4 6894 6171
Psmb5 7413 6135
Psmb6 6328 5606
Psmb7 4529 6188
Psmb8 -6836 3642
Psmb9 -7424 903
Psmc1 -2672 1371
Psmc2 4816 429
Psmc3 6685 6182
Psmc4 8055 5833
Psmc5 6075 6613
Psmc6 -5042 -5237
Psmd1 1230 -2032
Psmd10 5799 6777
Psmd11 -2334 825
Psmd12 -4520 -7821
Psmd13 7257 6935
Psmd14 137 6700
Psmd2 4201 -917
Psmd3 7906 6875
Psmd4 6593 3490
Psmd5 1735 -1276
Psmd6 2251 5121
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3349 6664
Psme1 7334 4530
Psme2 5471 8074
Psme3 -86 3241
Psme4 -5574 -2402
Psmf1 -1095 -378
Rbm8a -997 6211
Rbx1 -2574 1804
Rnps1 -2825 -2013
Robo1 -7726 -3154
Robo2 -8122 -5143
Robo3 -6656 -5945
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Sem1 6780 7134
Slit1 3447 -6943
Slit2 210 -4660
Uba52 4573 7321
Ubb 7203 86
Ubc 2610 -7073
Upf2 3281 -51
Upf3a 389 -1437
Upf3b 82 -601
Usp33 -3260 -3998
Zswim8 2276 -3667



CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
metric value
setSize 13
pMANOVA 0.0221
p.adjustMANOVA 0.099
s.dist 0.52
s.LPS 0.408
s.OVA 0.322
p.LPS 0.0108
p.OVA 0.0447



Top 20 genes
Gene LPS OVA
Nubp1 7691 7531
Ciapin1 8015 5563
Pold1 5189 8101
Brip1 4530 7442
Ciao1 6734 4060
Ercc2 6781 3843
Ciao3 4509 4719
Nubp2 3939 4172
Ciao2b 2746 1439

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All member genes
LPS OVA
Abcb7 -7355 -710
Brip1 4530 7442
Ciao1 6734 4060
Ciao2b 2746 1439
Ciao3 4509 4719
Ciapin1 8015 5563
Ercc2 6781 3843
Mms19 3367 -937
Ndor1 -2770 -3594
Nubp1 7691 7531
Nubp2 3939 4172
Pold1 5189 8101
Rtel1 235 -4739



ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
metric value
setSize 10
pMANOVA 0.0186
p.adjustMANOVA 0.0872
s.dist 0.505
s.LPS -0.0817
s.OVA -0.498
p.LPS 0.655
p.OVA 0.00636



Top 20 genes
Gene LPS OVA
Chrna5 -6179 -5274
Chrna1 -4329 -7106
Chrnb3 -1884 -8316
Chrna4 -1671 -7641
Chrna6 -1292 -8351
Chrna2 -7411 -1449
Chrna7 -567 -5478

Click HERE to show all gene set members

All member genes
LPS OVA
Chrna1 -4329 -7106
Chrna2 -7411 -1449
Chrna3 4593 520
Chrna4 -1671 -7641
Chrna5 -6179 -5274
Chrna6 -1292 -8351
Chrna7 -567 -5478
Chrnb2 4833 -2503
Chrnb3 -1884 -8316
Chrnb4 5928 4508



HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
metric value
setSize 10
pMANOVA 0.0186
p.adjustMANOVA 0.0872
s.dist 0.505
s.LPS -0.0817
s.OVA -0.498
p.LPS 0.655
p.OVA 0.00636



Top 20 genes
Gene LPS OVA
Chrna5 -6179 -5274
Chrna1 -4329 -7106
Chrnb3 -1884 -8316
Chrna4 -1671 -7641
Chrna6 -1292 -8351
Chrna2 -7411 -1449
Chrna7 -567 -5478

Click HERE to show all gene set members

All member genes
LPS OVA
Chrna1 -4329 -7106
Chrna2 -7411 -1449
Chrna3 4593 520
Chrna4 -1671 -7641
Chrna5 -6179 -5274
Chrna6 -1292 -8351
Chrna7 -567 -5478
Chrnb2 4833 -2503
Chrnb3 -1884 -8316
Chrnb4 5928 4508



RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA
metric value
setSize 24
pMANOVA 0.00111
p.adjustMANOVA 0.00999
s.dist 0.504
s.LPS -0.283
s.OVA -0.417
p.LPS 0.0164
p.OVA 0.000405



Top 20 genes
Gene LPS OVA
Blm -8306 -8353
Rad50 -8453 -7854
Rbbp8 -6149 -8263
Palb2 -6488 -7360
Wrn -6603 -6551
Nbn -5713 -7264
Rad51ap1 -4849 -7208
Rad51 -3687 -7819
Rad51d -2692 -7557
Xrcc3 -1705 -7936
Rmi2 -1764 -5697
Bard1 -3231 -2072
Top3a -943 -6600
Dna2 -157 -6204

Click HERE to show all gene set members

All member genes
LPS OVA
Atm -5073 284
Bard1 -3231 -2072
Blm -8306 -8353
Brca1 2702 6887
Brca2 -2938 4070
Brip1 4530 7442
Dna2 -157 -6204
Kat5 6330 -5303
Mre11a -2936 129
Nbn -5713 -7264
Palb2 -6488 -7360
Rad50 -8453 -7854
Rad51 -3687 -7819
Rad51ap1 -4849 -7208
Rad51c 580 -4046
Rad51d -2692 -7557
Rbbp8 -6149 -8263
Rmi1 -2283 2807
Rmi2 -1764 -5697
Rtel1 235 -4739
Top3a -943 -6600
Wrn -6603 -6551
Xrcc2 -467 7194
Xrcc3 -1705 -7936



DSCAM INTERACTIONS
DSCAM INTERACTIONS
metric value
setSize 10
pMANOVA 0.059
p.adjustMANOVA 0.195
s.dist 0.501
s.LPS -0.274
s.OVA -0.42
p.LPS 0.134
p.OVA 0.0216



Top 20 genes
Gene LPS OVA
Mapk8 -8250 -7436
Pak1 -4955 -6385
Ntn1 -5680 -4855
Dscaml1 -4816 -3524
Dcc -8429 -1796

Click HERE to show all gene set members

All member genes
LPS OVA
Dcc -8429 -1796
Dscam 1581 -5760
Dscaml1 -4816 -3524
Mapk11 5281 -4752
Mapk12 2520 -2590
Mapk14 1862 -1635
Mapk8 -8250 -7436
Ntn1 -5680 -4855
Pak1 -4955 -6385
Rac1 -3366 4307



PHASE 0 RAPID DEPOLARISATION
PHASE 0 RAPID DEPOLARISATION
metric value
setSize 30
pMANOVA 0.000354
p.adjustMANOVA 0.004
s.dist 0.495
s.LPS -0.309
s.OVA -0.387
p.LPS 0.00345
p.OVA 0.000248



Top 20 genes
Gene LPS OVA
Scn3b -6813 -7458
Fgf14 -7559 -6621
Fgf12 -8155 -4506
Cacng6 -5733 -6361
Fgf13 -4742 -7654
Cacnb2 -4898 -6685
Camk2d -7181 -4025
Scn4b -7779 -3679
Scn8a -7952 -3435
Cacng7 -3846 -6948
Scn1a -7810 -2337
Scn2a -5633 -1972
Cacna2d2 -2540 -2555
Scn2b -1683 -3557
Camk2a -7584 -713
Scn3a -5690 -860
Fgf11 -7687 -231

Click HERE to show all gene set members

All member genes
LPS OVA
Cacna1c 1732 274
Cacna2d2 -2540 -2555
Cacnb1 1007 -6851
Cacnb2 -4898 -6685
Cacng4 4455 -2514
Cacng6 -5733 -6361
Cacng7 -3846 -6948
Cacng8 3582 -2220
Calm1 -7890 1510
Camk2a -7584 -713
Camk2b 1425 -7171
Camk2d -7181 -4025
Camk2g 4818 -7793
Fgf11 -7687 -231
Fgf12 -8155 -4506
Fgf13 -4742 -7654
Fgf14 -7559 -6621
Rangrf 302 -500
Scn11a 4632 929
Scn1a -7810 -2337
Scn1b 1640 -6252
Scn2a -5633 -1972
Scn2b -1683 -3557
Scn3a -5690 -860
Scn3b -6813 -7458
Scn4b -7779 -3679
Scn5a 2701 -4628
Scn7a 1453 4270
Scn8a -7952 -3435
Scn9a 1919 5796



RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
metric value
setSize 125
pMANOVA 2.59e-18
p.adjustMANOVA 3.04e-16
s.dist 0.492
s.LPS 0.16
s.OVA 0.465
p.LPS 0.002
p.OVA 2.74e-19



Top 20 genes
Gene LPS OVA
Ucp2 8047 7602
Ndufa2 6084 7875
Ndufaf6 7697 5974
Timmdc1 6640 6660
Ndufb2 5640 7622
Surf1 5903 6927
Atp5k 5706 7128
Ndufb10 5856 6670
Cyc1 6855 5566
Ndufv1 5257 6551
Ndufaf5 4554 7307
Ndufaf3 7585 4364
Ndufa1 4522 7212
Ndufb1 4995 6470
mt-Atp8 4024 7998
Ndufa6 5426 5703
Ecsit 4980 6204
Atp5d 5782 5289
Uqcr10 5312 5659
Ndufs5 5544 5354

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 7184 -238
Atp5a1 264 3481
Atp5b 2737 2753
Atp5c1 -2591 3513
Atp5d 5782 5289
Atp5e 2735 7349
Atp5g1 5286 3351
Atp5g2 1393 8352
Atp5g3 552 5969
Atp5h 188 6232
Atp5j 1202 3834
Atp5j2 2054 3874
Atp5k 5706 7128
Atp5l 1542 6454
Atp5o 1967 98
Atp5pb -2002 823
Coq10a 4179 1682
Coq10b -4271 5985
Cox11 464 1336
Cox14 3481 2135
Cox16 1101 5466
Cox18 5536 2909
Cox19 773 -1022
Cox20 -1939 5152
Cox4i1 1157 6149
Cox5a 1928 5181
Cox5b 2832 5976
Cox6a1 3673 7304
Cox6b1 2767 5479
Cox6c -308 4976
Cox7a2l -1131 6224
Cox7b -83 2700
Cox7c -2832 5168
Cox8a 5033 5622
Cyc1 6855 5566
Cycs -7082 1127
Dmac2l -6808 1963
Ecsit 4980 6204
Etfa -2041 3559
Etfb 3384 5669
Etfdh 485 -4477
Lrpprc -827 -6266
mt-Atp6 -6870 6350
mt-Atp8 4024 7998
mt-Co1 -6018 6684
mt-Co2 -5078 6098
mt-Co3 -5786 5816
mt-Cytb -5603 6164
mt-Nd1 -6354 6107
mt-Nd2 -5139 6601
mt-Nd3 -6174 7841
mt-Nd4 -6828 6611
mt-Nd5 -6424 6942
mt-Nd6 -4602 7427
Ndufa1 4522 7212
Ndufa10 -1599 -3057
Ndufa11 4909 5113
Ndufa12 898 3636
Ndufa13 5502 5339
Ndufa2 6084 7875
Ndufa3 3719 5991
Ndufa4 -2874 4273
Ndufa5 -426 5104
Ndufa6 5426 5703
Ndufa7 4012 5896
Ndufa8 2460 3276
Ndufa9 -4162 883
Ndufab1 4221 5489
Ndufaf1 -3804 6803
Ndufaf2 -5654 1337
Ndufaf3 7585 4364
Ndufaf4 -5981 -1991
Ndufaf5 4554 7307
Ndufaf6 7697 5974
Ndufaf7 2507 6594
Ndufb1 4995 6470
Ndufb10 5856 6670
Ndufb11 4314 6610
Ndufb2 5640 7622
Ndufb3 -730 2044
Ndufb4 -1297 5820
Ndufb5 -603 4684
Ndufb6 731 4755
Ndufb7 5169 4927
Ndufb8 4884 5973
Ndufb9 -303 6512
Ndufc1 244 5855
Ndufc2 1754 5872
Ndufs1 -4604 -3894
Ndufs2 3053 3752
Ndufs3 2654 7122
Ndufs4 -4324 3535
Ndufs5 5544 5354
Ndufs6 2864 6189
Ndufs7 7071 4108
Ndufs8 6562 3004
Ndufv1 5257 6551
Ndufv2 -2332 2393
Ndufv3 1679 3060
Nubpl -2947 3902
Pm20d1 3301 7170
Sco1 -3594 -5700
Sco2 6761 -1166
Sdha 1657 -4474
Sdhb 5449 2811
Sdhc 2074 4645
Sdhd 3898 2542
Slc25a14 2498 7921
Slc25a27 -823 -7280
Surf1 5903 6927
Taco1 5040 3907
Timmdc1 6640 6660
Tmem126b 4955 -1178
Tmem186 2756 -7026
Trap1 5260 2655
Ucp2 8047 7602
Ucp3 -1557 -5620
Uqcr10 5312 5659
Uqcr11 3598 5725
Uqcrb -3799 2946
Uqcrc1 5173 3630
Uqcrc2 -4464 -1104
Uqcrfs1 981 1398
Uqcrh 196 5904
Uqcrq 4848 5949



TRANSLATION
TRANSLATION
metric value
setSize 286
pMANOVA 3.5e-34
p.adjustMANOVA 4.11e-31
s.dist 0.489
s.LPS 0.26
s.OVA 0.414
p.LPS 3.84e-14
p.OVA 1.65e-33



Top 20 genes
Gene LPS OVA
Apeh 8338 8363
Mrps35 7770 8114
Eral1 7602 8171
Mrps6 7465 7759
Eif4a1 7428 7715
Mrpl9 7432 7659
Mrpl14 7719 7231
Eif3b 7633 7180
Fars2 7632 6923
Eef1d 7466 7064
Mrpl23 6316 8303
Yars2 8248 6175
Rpl8 6585 7422
Aimp2 6191 7845
Rps29 5843 8225
Rps5 6498 7375
Rps6 6406 7423
Rpl39 5847 8124
Rpl38 5942 7800
Rps21 5711 8072

Click HERE to show all gene set members

All member genes
LPS OVA
Aars 4531 -5153
Aars2 7220 -2875
Aimp1 4742 6219
Aimp2 6191 7845
Apeh 8338 8363
Aurkaip1 5768 4926
Cars 6627 47
Cars2 5622 2528
Chchd1 4812 6701
Dap3 -1395 5795
Dars -6594 -5526
Dars2 -1363 3233
Ddost 6409 2866
Ears2 4906 2115
Eef1a1 4371 6243
Eef1a2 4093 -4811
Eef1b2 6050 6897
Eef1d 7466 7064
Eef1e1 5007 5633
Eef1g 985 5648
Eef2 5786 4599
Eif1ax -7793 -5142
Eif2b1 -1745 -5602
Eif2b2 7707 1152
Eif2b3 -3476 452
Eif2b4 4726 5762
Eif2b5 6354 6434
Eif2s1 -5543 -2135
Eif2s2 -5715 3812
Eif2s3x -3701 3844
Eif3a 192 -5791
Eif3b 7633 7180
Eif3c 3170 407
Eif3d 7020 5543
Eif3e -7457 5707
Eif3f 4929 8100
Eif3g 5108 2047
Eif3h 5018 4170
Eif3i 6161 5376
Eif3j1 -5830 481
Eif3j2 -5550 7555
Eif3k 4251 5012
Eif3l 6344 6596
Eif3m -3388 6058
Eif4a1 7428 7715
Eif4a2 -7772 -2030
Eif4b -1945 -2667
Eif4e -563 3694
Eif4ebp1 -3320 4471
Eif4g1 5030 -2226
Eif4h 4881 -21
Eif5 -7861 -3706
Eif5b -5791 991
Eprs -7826 -4236
Eral1 7602 8171
Etf1 -5324 -5319
Fars2 7632 6923
Farsa 6235 4797
Farsb 5095 -4915
Fau 5367 7429
Gadd45gip1 7336 2901
Gars 2535 -5180
Gfm1 -7115 -4213
Gfm2 1998 2076
Gspt1 -966 -2334
Gspt2 2513 -4743
Hars 4480 -491
Hars2 1337 1694
Iars -1516 -7685
Iars2 -592 937
Kars 2956 1022
Lars -6729 -4563
Lars2 -723 8527
Mars1 7772 -3073
Mars2 -6909 -198
Mrpl1 -7735 -7639
Mrpl10 170 -1201
Mrpl11 3824 6007
Mrpl12 6035 5939
Mrpl13 599 3042
Mrpl14 7719 7231
Mrpl15 783 4759
Mrpl16 646 7057
Mrpl17 3405 4617
Mrpl18 4867 2591
Mrpl19 2710 -1440
Mrpl2 3453 4351
Mrpl20 3059 4376
Mrpl21 3238 3818
Mrpl22 1329 -3362
Mrpl23 6316 8303
Mrpl24 4330 5621
Mrpl27 6158 3655
Mrpl28 5345 5700
Mrpl3 -3686 1951
Mrpl30 397 2533
Mrpl32 -5629 6961
Mrpl33 -1850 4932
Mrpl34 5986 5591
Mrpl35 2188 6734
Mrpl36 6877 6627
Mrpl37 5963 5911
Mrpl38 7754 259
Mrpl39 1340 -821
Mrpl4 7101 5738
Mrpl40 3529 701
Mrpl41 1541 5503
Mrpl42 1962 4672
Mrpl43 6958 5476
Mrpl44 -4397 -3167
Mrpl46 4615 5357
Mrpl47 -2215 7051
Mrpl48 -490 4620
Mrpl49 5052 537
Mrpl50 -5583 1032
Mrpl51 4315 8240
Mrpl52 5904 7358
Mrpl53 4892 6246
Mrpl54 3079 4681
Mrpl55 -410 -4898
Mrpl57 4100 4720
Mrpl58 4492 2009
Mrpl9 7432 7659
Mrps10 -3653 236
Mrps11 6165 2180
Mrps12 7312 628
Mrps14 -2872 4579
Mrps15 1132 6286
Mrps16 362 4869
Mrps17 1992 6323
Mrps18a 3718 791
Mrps18b -1818 1873
Mrps18c 1139 6583
Mrps2 -3570 -722
Mrps21 2690 4507
Mrps22 3951 2101
Mrps23 3500 6179
Mrps24 3119 3769
Mrps25 1638 1324
Mrps26 6384 3712
Mrps27 7380 4454
Mrps28 3960 449
Mrps30 4799 5683
Mrps31 -1650 -7097
Mrps33 1427 4430
Mrps34 7082 3934
Mrps35 7770 8114
Mrps36 -5483 115
Mrps5 -3956 -6846
Mrps6 7465 7759
Mrps7 5971 5107
Mrps9 6260 6765
Mrrf 7589 -1580
Mtfmt 2483 2740
Mtif2 -3908 54
Mtif3 -1448 -4341
Mtrf1l 3454 2372
N6amt1 -2835 -1337
Nars -1263 -1811
Nars2 -7369 3
Oxa1l 4577 3762
Pabpc1 -6868 5519
Pars2 5809 3985
Ppa1 5141 4246
Ppa2 2016 2467
Ptcd3 -6185 -8003
Qars 5806 7196
Rars -12 -3127
Rars2 -2042 -2035
Rpl10 4562 5827
Rpl10a 2650 6055
Rpl11 1986 5718
Rpl12 3663 4868
Rpl13 6166 7175
Rpl13a -807 7465
Rpl14 -729 6578
Rpl15 1349 5460
Rpl17 -2929 6303
Rpl18 4486 6801
Rpl18a 4064 7197
Rpl19 5546 6847
Rpl21 5182 6382
Rpl22 -2022 5544
Rpl22l1 -3936 7385
Rpl23 2293 6877
Rpl23a 3921 6522
Rpl24 -1382 5864
Rpl26 5486 5434
Rpl27 3573 6992
Rpl27a 2273 7299
Rpl28 714 4140
Rpl29 -1455 4795
Rpl3 177 7967
Rpl30 -6575 6237
Rpl31 3647 6713
Rpl32 1946 6812
Rpl34 1853 6998
Rpl35 3126 7652
Rpl35a -2845 6435
Rpl36 5913 7633
Rpl36a 3605 6312
Rpl36al 4569 7053
Rpl37 3278 6831
Rpl37a 4548 7337
Rpl38 5942 7800
Rpl39 5847 8124
Rpl4 3161 6152
Rpl5 -5338 5772
Rpl6 3092 4555
Rpl7 -484 6090
Rpl7a 4744 4295
Rpl8 6585 7422
Rpl9 494 7158
Rplp0 3007 6338
Rplp1 5261 7625
Rplp2 4991 7649
Rpn1 4997 3395
Rpn2 6176 5526
Rps10 4340 7198
Rps11 -894 5799
Rps12 3606 7179
Rps13 1006 7113
Rps14 2987 7131
Rps15 5393 6985
Rps15a 5456 6416
Rps16 -1526 7117
Rps17 2017 6663
Rps18 -5871 4462
Rps19 3727 7799
Rps2 -5578 2126
Rps20 5501 7928
Rps21 5711 8072
Rps23 -63 7076
Rps24 135 7169
Rps25 -959 6266
Rps26 556 5660
Rps27 3173 7850
Rps27a 2530 7576
Rps27l -3674 6934
Rps28 5823 7818
Rps29 5843 8225
Rps3 2679 7508
Rps3a1 3387 7394
Rps4x -1467 6463
Rps5 6498 7375
Rps6 6406 7423
Rps7 -3855 3251
Rps8 4983 7371
Rps9 4136 7518
Rpsa 5435 7739
Sars 1048 -8012
Sars2 1057 -3379
Sec11a -216 2994
Sec11c -1020 5409
Sec61a1 4890 505
Sec61a2 -5000 -5427
Sec61b 5178 7543
Sec61g 5282 8012
Spcs1 2563 7606
Spcs2 -344 4906
Spcs3 -8166 -1009
Srp14 2204 2658
Srp19 390 5880
Srp54a -6107 2529
Srp68 6255 157
Srp72 4189 -1834
Srp9 -3616 4163
Srpr 6466 63
Srprb 5692 -3733
Ssr1 -4519 -1071
Ssr2 4437 4809
Ssr3 -3654 7761
Ssr4 6356 6476
Tars 5999 -2408
Tars2 6777 3578
Tram1 -5657 6723
Trmt112 3880 2825
Tsfm 2675 2710
Tufm 7384 4431
Uba52 4573 7321
Vars 6718 3584
Vars2 4441 2068
Wars 5759 -3782
Wars2 -1658 -4113
Yars 6207 -4545
Yars2 8248 6175



AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
metric value
setSize 53
pMANOVA 1.34e-06
p.adjustMANOVA 4.34e-05
s.dist 0.489
s.LPS 0.325
s.OVA 0.365
p.LPS 4.22e-05
p.OVA 4.33e-06



Top 20 genes
Gene LPS OVA
Hspb1 7721 7882
Psmd3 7906 6875
Psmd13 7257 6935
Sem1 6780 7134
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6135
Psmb2 6181 7347
Psme2 5471 8074
Psmb4 6894 6171
Psmc3 6685 6182
Psmc5 6075 6613
Psmd10 5799 6777
Psmb6 6328 5606
Uba52 4573 7321
Psme1 7334 4530
Psmd8 5319 6063
Psmb7 4529 6188
Psmb10 4825 5736
Psmb1 4456 5798

Click HERE to show all gene set members

All member genes
LPS OVA
Eif4g1 5030 -2226
Hnrnpd -7249 -1251
Hspa1a -830 -8090
Hspa8 3709 -4246
Hspb1 7721 7882
Pabpc1 -6868 5519
Psma1 -841 5990
Psma2 4139 4580
Psma3 -1200 7148
Psma4 -129 1874
Psma5 5707 3544
Psma6 2309 4521
Psma7 4000 4639
Psmb1 4456 5798
Psmb10 4825 5736
Psmb2 6181 7347
Psmb3 3566 5508
Psmb4 6894 6171
Psmb5 7413 6135
Psmb6 6328 5606
Psmb7 4529 6188
Psmb8 -6836 3642
Psmb9 -7424 903
Psmc1 -2672 1371
Psmc2 4816 429
Psmc3 6685 6182
Psmc4 8055 5833
Psmc5 6075 6613
Psmc6 -5042 -5237
Psmd1 1230 -2032
Psmd10 5799 6777
Psmd11 -2334 825
Psmd12 -4520 -7821
Psmd13 7257 6935
Psmd14 137 6700
Psmd2 4201 -917
Psmd3 7906 6875
Psmd4 6593 3490
Psmd5 1735 -1276
Psmd6 2251 5121
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3349 6664
Psme1 7334 4530
Psme2 5471 8074
Psme3 -86 3241
Psme4 -5574 -2402
Psmf1 -1095 -378
Rps27a 2530 7576
Sem1 6780 7134
Uba52 4573 7321
Ubb 7203 86
Ubc 2610 -7073



RESPIRATORY ELECTRON TRANSPORT
RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 102
pMANOVA 6.65e-15
p.adjustMANOVA 6.51e-13
s.dist 0.489
s.LPS 0.16
s.OVA 0.462
p.LPS 0.0053
p.OVA 7.49e-16



Top 20 genes
Gene LPS OVA
Ndufa2 6084 7875
Ndufaf6 7697 5974
Timmdc1 6640 6660
Ndufb2 5640 7622
Surf1 5903 6927
Ndufb10 5856 6670
Cyc1 6855 5566
Ndufv1 5257 6551
Ndufaf5 4554 7307
Ndufaf3 7585 4364
Ndufa1 4522 7212
Ndufb1 4995 6470
Ndufa6 5426 5703
Ecsit 4980 6204
Uqcr10 5312 5659
Ndufs5 5544 5354
Ndufa13 5502 5339
Ndufb8 4884 5973
Ndufs7 7071 4108
Uqcrq 4848 5949

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 7184 -238
Coq10a 4179 1682
Coq10b -4271 5985
Cox11 464 1336
Cox14 3481 2135
Cox16 1101 5466
Cox18 5536 2909
Cox19 773 -1022
Cox20 -1939 5152
Cox4i1 1157 6149
Cox5a 1928 5181
Cox5b 2832 5976
Cox6a1 3673 7304
Cox6b1 2767 5479
Cox6c -308 4976
Cox7a2l -1131 6224
Cox7b -83 2700
Cox7c -2832 5168
Cox8a 5033 5622
Cyc1 6855 5566
Cycs -7082 1127
Ecsit 4980 6204
Etfa -2041 3559
Etfb 3384 5669
Etfdh 485 -4477
Lrpprc -827 -6266
mt-Co1 -6018 6684
mt-Co2 -5078 6098
mt-Co3 -5786 5816
mt-Cytb -5603 6164
mt-Nd1 -6354 6107
mt-Nd2 -5139 6601
mt-Nd3 -6174 7841
mt-Nd4 -6828 6611
mt-Nd5 -6424 6942
mt-Nd6 -4602 7427
Ndufa1 4522 7212
Ndufa10 -1599 -3057
Ndufa11 4909 5113
Ndufa12 898 3636
Ndufa13 5502 5339
Ndufa2 6084 7875
Ndufa3 3719 5991
Ndufa4 -2874 4273
Ndufa5 -426 5104
Ndufa6 5426 5703
Ndufa7 4012 5896
Ndufa8 2460 3276
Ndufa9 -4162 883
Ndufab1 4221 5489
Ndufaf1 -3804 6803
Ndufaf2 -5654 1337
Ndufaf3 7585 4364
Ndufaf4 -5981 -1991
Ndufaf5 4554 7307
Ndufaf6 7697 5974
Ndufaf7 2507 6594
Ndufb1 4995 6470
Ndufb10 5856 6670
Ndufb11 4314 6610
Ndufb2 5640 7622
Ndufb3 -730 2044
Ndufb4 -1297 5820
Ndufb5 -603 4684
Ndufb6 731 4755
Ndufb7 5169 4927
Ndufb8 4884 5973
Ndufb9 -303 6512
Ndufc1 244 5855
Ndufc2 1754 5872
Ndufs1 -4604 -3894
Ndufs2 3053 3752
Ndufs3 2654 7122
Ndufs4 -4324 3535
Ndufs5 5544 5354
Ndufs6 2864 6189
Ndufs7 7071 4108
Ndufs8 6562 3004
Ndufv1 5257 6551
Ndufv2 -2332 2393
Ndufv3 1679 3060
Nubpl -2947 3902
Sco1 -3594 -5700
Sco2 6761 -1166
Sdha 1657 -4474
Sdhb 5449 2811
Sdhc 2074 4645
Sdhd 3898 2542
Surf1 5903 6927
Taco1 5040 3907
Timmdc1 6640 6660
Tmem126b 4955 -1178
Tmem186 2756 -7026
Trap1 5260 2655
Uqcr10 5312 5659
Uqcr11 3598 5725
Uqcrb -3799 2946
Uqcrc1 5173 3630
Uqcrc2 -4464 -1104
Uqcrfs1 981 1398
Uqcrh 196 5904
Uqcrq 4848 5949



CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
metric value
setSize 11
pMANOVA 0.0588
p.adjustMANOVA 0.195
s.dist 0.488
s.LPS -0.38
s.OVA -0.305
p.LPS 0.0289
p.OVA 0.0796



Top 20 genes
Gene LPS OVA
Adcy8 -6503 -8299
Adcy1 -8384 -3296
Prkx -6751 -2681
Prkacb -3493 -3262
Prkar1a -2075 -3763
Prkar2b -7901 -393
Prkar2a -147 -2857

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 -8384 -3296
Adcy8 -6503 -8299
Calm1 -7890 1510
Creb1 -4262 3501
Prkaca 5362 -3518
Prkacb -3493 -3262
Prkar1a -2075 -3763
Prkar1b 5432 -4141
Prkar2a -147 -2857
Prkar2b -7901 -393
Prkx -6751 -2681



ASPARTATE AND ASPARAGINE METABOLISM
ASPARTATE AND ASPARAGINE METABOLISM
metric value
setSize 10
pMANOVA 0.0794
p.adjustMANOVA 0.234
s.dist 0.484
s.LPS -0.305
s.OVA -0.376
p.LPS 0.0951
p.OVA 0.0395



Top 20 genes
Gene LPS OVA
Aspa -8207 -5671
Got1 -5044 -7183
Asns -4365 -6331
Got2 -2826 -5843
Folh1 -5180 -220
Slc25a12 -181 -4369

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -4365 -6331
Aspa -8207 -5671
Aspg 351 -3277
Folh1 -5180 -220
Got1 -5044 -7183
Got2 -2826 -5843
Naalad2 -3126 1537
Nat8l 1442 -6736
Slc25a12 -181 -4369
Slc25a13 252 7372



SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
metric value
setSize 13
pMANOVA 0.00921
p.adjustMANOVA 0.052
s.dist 0.483
s.LPS 0.0844
s.OVA 0.476
p.LPS 0.598
p.OVA 0.00298



Top 20 genes
Gene LPS OVA
Ptgis 8020 8468
Prxl2b 6533 7909
Ptges2 7163 7083
Ptgds 5901 8066
Tbxas1 1713 8386
Ptges 4988 2424

Click HERE to show all gene set members

All member genes
LPS OVA
Cbr1 4849 -38
Hpgd -3168 8004
Hpgds -4812 2075
Prxl2b 6533 7909
Ptgds 5901 8066
Ptges 4988 2424
Ptges2 7163 7083
Ptges3 -673 7374
Ptgis 8020 8468
Ptgr2 -6953 2119
Ptgs1 -7130 155
Ptgs2 -8503 -8168
Tbxas1 1713 8386



STABILIZATION OF P53
STABILIZATION OF P53
metric value
setSize 54
pMANOVA 1.48e-06
p.adjustMANOVA 4.58e-05
s.dist 0.481
s.LPS 0.312
s.OVA 0.366
p.LPS 7.15e-05
p.OVA 3.23e-06



Top 20 genes
Gene LPS OVA
Psmd3 7906 6875
Psmd13 7257 6935
Sem1 6780 7134
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6135
Psmb2 6181 7347
Psme2 5471 8074
Psmb4 6894 6171
Psmc3 6685 6182
Psmc5 6075 6613
Psmd10 5799 6777
Psmb6 6328 5606
Uba52 4573 7321
Psme1 7334 4530
Psmd8 5319 6063
Psmb7 4529 6188
Psmb10 4825 5736
Psmb1 4456 5798
Psmd4 6593 3490

Click HERE to show all gene set members

All member genes
LPS OVA
Atm -5073 284
Chek2 2981 1501
Cop1 1815 8427
Mdm2 119 -6203
Mdm4 -682 1883
Phf20 -2026 -1956
Psma1 -841 5990
Psma2 4139 4580
Psma3 -1200 7148
Psma4 -129 1874
Psma5 5707 3544
Psma6 2309 4521
Psma7 4000 4639
Psmb1 4456 5798
Psmb10 4825 5736
Psmb2 6181 7347
Psmb3 3566 5508
Psmb4 6894 6171
Psmb5 7413 6135
Psmb6 6328 5606
Psmb7 4529 6188
Psmb8 -6836 3642
Psmb9 -7424 903
Psmc1 -2672 1371
Psmc2 4816 429
Psmc3 6685 6182
Psmc4 8055 5833
Psmc5 6075 6613
Psmc6 -5042 -5237
Psmd1 1230 -2032
Psmd10 5799 6777
Psmd11 -2334 825
Psmd12 -4520 -7821
Psmd13 7257 6935
Psmd14 137 6700
Psmd2 4201 -917
Psmd3 7906 6875
Psmd4 6593 3490
Psmd5 1735 -1276
Psmd6 2251 5121
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3349 6664
Psme1 7334 4530
Psme2 5471 8074
Psme3 -86 3241
Psme4 -5574 -2402
Psmf1 -1095 -378
Rps27a 2530 7576
Sem1 6780 7134
Trp53 1189 -2520
Uba52 4573 7321
Ubb 7203 86
Ubc 2610 -7073



SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
metric value
setSize 12
pMANOVA 0.0338
p.adjustMANOVA 0.134
s.dist 0.479
s.LPS 0.205
s.OVA 0.433
p.LPS 0.218
p.OVA 0.00943



Top 20 genes
Gene LPS OVA
Ptgis 8020 8468
Slc27a2 7277 7241
Acot8 7862 6576
Rxra 6327 5359
Hsd3b7 2124 8451
Amacr 5579 2723
Hsd17b4 150 1875

Click HERE to show all gene set members

All member genes
LPS OVA
Acot8 7862 6576
Amacr 5579 2723
Cyp27a1 -104 -5001
Cyp7b1 -1694 7950
Hsd17b4 150 1875
Hsd3b7 2124 8451
Ncoa1 -6490 -2978
Ncoa2 -7279 -2188
Ptgis 8020 8468
Rxra 6327 5359
Scp2 -2168 6888
Slc27a2 7277 7241



MITOCHONDRIAL TRANSLATION
MITOCHONDRIAL TRANSLATION
metric value
setSize 93
pMANOVA 1.35e-10
p.adjustMANOVA 7.54e-09
s.dist 0.478
s.LPS 0.313
s.OVA 0.362
p.LPS 1.9e-07
p.OVA 1.65e-09



Top 20 genes
Gene LPS OVA
Mrps35 7770 8114
Eral1 7602 8171
Mrps6 7465 7759
Mrpl9 7432 7659
Mrpl14 7719 7231
Mrpl23 6316 8303
Mrpl36 6877 6627
Mrpl52 5904 7358
Mrps9 6260 6765
Mrpl4 7101 5738
Mrpl43 6958 5476
Mrpl12 6035 5939
Mrpl51 4315 8240
Mrpl37 5963 5911
Mrpl34 5986 5591
Mrps27 7380 4454
Tufm 7384 4431
Chchd1 4812 6701
Mrpl53 4892 6246
Mrps7 5971 5107

Click HERE to show all gene set members

All member genes
LPS OVA
Aurkaip1 5768 4926
Chchd1 4812 6701
Dap3 -1395 5795
Eral1 7602 8171
Gadd45gip1 7336 2901
Gfm1 -7115 -4213
Gfm2 1998 2076
Mrpl1 -7735 -7639
Mrpl10 170 -1201
Mrpl11 3824 6007
Mrpl12 6035 5939
Mrpl13 599 3042
Mrpl14 7719 7231
Mrpl15 783 4759
Mrpl16 646 7057
Mrpl17 3405 4617
Mrpl18 4867 2591
Mrpl19 2710 -1440
Mrpl2 3453 4351
Mrpl20 3059 4376
Mrpl21 3238 3818
Mrpl22 1329 -3362
Mrpl23 6316 8303
Mrpl24 4330 5621
Mrpl27 6158 3655
Mrpl28 5345 5700
Mrpl3 -3686 1951
Mrpl30 397 2533
Mrpl32 -5629 6961
Mrpl33 -1850 4932
Mrpl34 5986 5591
Mrpl35 2188 6734
Mrpl36 6877 6627
Mrpl37 5963 5911
Mrpl38 7754 259
Mrpl39 1340 -821
Mrpl4 7101 5738
Mrpl40 3529 701
Mrpl41 1541 5503
Mrpl42 1962 4672
Mrpl43 6958 5476
Mrpl44 -4397 -3167
Mrpl46 4615 5357
Mrpl47 -2215 7051
Mrpl48 -490 4620
Mrpl49 5052 537
Mrpl50 -5583 1032
Mrpl51 4315 8240
Mrpl52 5904 7358
Mrpl53 4892 6246
Mrpl54 3079 4681
Mrpl55 -410 -4898
Mrpl57 4100 4720
Mrpl58 4492 2009
Mrpl9 7432 7659
Mrps10 -3653 236
Mrps11 6165 2180
Mrps12 7312 628
Mrps14 -2872 4579
Mrps15 1132 6286
Mrps16 362 4869
Mrps17 1992 6323
Mrps18a 3718 791
Mrps18b -1818 1873
Mrps18c 1139 6583
Mrps2 -3570 -722
Mrps21 2690 4507
Mrps22 3951 2101
Mrps23 3500 6179
Mrps24 3119 3769
Mrps25 1638 1324
Mrps26 6384 3712
Mrps27 7380 4454
Mrps28 3960 449
Mrps30 4799 5683
Mrps31 -1650 -7097
Mrps33 1427 4430
Mrps34 7082 3934
Mrps35 7770 8114
Mrps36 -5483 115
Mrps5 -3956 -6846
Mrps6 7465 7759
Mrps7 5971 5107
Mrps9 6260 6765
Mrrf 7589 -1580
Mtfmt 2483 2740
Mtif2 -3908 54
Mtif3 -1448 -4341
Mtrf1l 3454 2372
Oxa1l 4577 3762
Ptcd3 -6185 -8003
Tsfm 2675 2710
Tufm 7384 4431



WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
metric value
setSize 13
pMANOVA 0.00832
p.adjustMANOVA 0.0487
s.dist 0.474
s.LPS 0.471
s.OVA 0.0516
p.LPS 0.00326
p.OVA 0.747



Top 20 genes
Gene LPS OVA
Fzd2 7758 8458
Cltb 7548 5247
Fzd5 6159 5840
Clta 6828 5244
Ap2s1 6318 2503
Ror1 2841 4916

Click HERE to show all gene set members

All member genes
LPS OVA
Ap2a1 6603 -1072
Ap2a2 4269 -3196
Ap2b1 -2180 -4663
Ap2m1 6014 -2522
Ap2s1 6318 2503
Clta 6828 5244
Cltb 7548 5247
Cltc -5079 -3634
Fzd2 7758 8458
Fzd5 6159 5840
Ror1 2841 4916
Ror2 918 -2605
Wnt5a 2539 -7355



CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
metric value
setSize 10
pMANOVA 0.0519
p.adjustMANOVA 0.178
s.dist 0.472
s.LPS -0.16
s.OVA -0.444
p.LPS 0.381
p.OVA 0.0151



Top 20 genes
Gene LPS OVA
Unc5b -7480 -8147
Appl1 -6326 -4300
Casp9 -5916 -3502
Dcc -8429 -1796
Dapk2 -1378 -5667
Casp3 -2337 -1373
Dapk1 -78 -3652

Click HERE to show all gene set members

All member genes
LPS OVA
Appl1 -6326 -4300
Casp3 -2337 -1373
Casp9 -5916 -3502
Dapk1 -78 -3652
Dapk2 -1378 -5667
Dapk3 7759 3987
Dcc -8429 -1796
Maged1 5937 -3839
Unc5a 3627 -8172
Unc5b -7480 -8147



THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT
metric value
setSize 66
pMANOVA 8.88e-08
p.adjustMANOVA 4.01e-06
s.dist 0.47
s.LPS 0.389
s.OVA 0.264
p.LPS 4.67e-08
p.OVA 0.000214



Top 20 genes
Gene LPS OVA
Psmd3 7906 6875
Tuba1a 7803 6915
Tuba1b 7786 6590
Psmd13 7257 6935
Sem1 6780 7134
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6135
Psmb2 6181 7347
Psme2 5471 8074
Psmb4 6894 6171
Psmc3 6685 6182
Psmc5 6075 6613
Psmd10 5799 6777
Tubb6 7355 4843
Psmb6 6328 5606
Uba52 4573 7321
Psme1 7334 4530
Psmd8 5319 6063
Psmb7 4529 6188

Click HERE to show all gene set members

All member genes
LPS OVA
Ccnb2 4073 6504
Cdkn1a 2161 -4365
Fkbpl -3817 -4446
Hsp90aa1 -7543 -7943
Hsp90ab1 1997 -6842
Mapre1 -5357 5562
Plk1 6266 -7979
Psma1 -841 5990
Psma2 4139 4580
Psma3 -1200 7148
Psma4 -129 1874
Psma5 5707 3544
Psma6 2309 4521
Psma7 4000 4639
Psmb1 4456 5798
Psmb10 4825 5736
Psmb2 6181 7347
Psmb3 3566 5508
Psmb4 6894 6171
Psmb5 7413 6135
Psmb6 6328 5606
Psmb7 4529 6188
Psmb8 -6836 3642
Psmb9 -7424 903
Psmc1 -2672 1371
Psmc2 4816 429
Psmc3 6685 6182
Psmc4 8055 5833
Psmc5 6075 6613
Psmc6 -5042 -5237
Psmd1 1230 -2032
Psmd10 5799 6777
Psmd11 -2334 825
Psmd12 -4520 -7821
Psmd13 7257 6935
Psmd14 137 6700
Psmd2 4201 -917
Psmd3 7906 6875
Psmd4 6593 3490
Psmd5 1735 -1276
Psmd6 2251 5121
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3349 6664
Psme1 7334 4530
Psme2 5471 8074
Psme3 -86 3241
Psme4 -5574 -2402
Psmf1 -1095 -378
Rps27a 2530 7576
Sem1 6780 7134
Trp53 1189 -2520
Tuba1a 7803 6915
Tuba1b 7786 6590
Tuba1c 2927 6642
Tuba4a 5111 -5124
Tuba8 4699 -6670
Tubb2a 7932 1277
Tubb2b 6404 -908
Tubb3 7161 -4852
Tubb4a 7131 -5164
Tubb4b 7939 1029
Tubb6 7355 4843
Uba52 4573 7321
Ubb 7203 86
Ubc 2610 -7073



GLUTATHIONE SYNTHESIS AND RECYCLING
GLUTATHIONE SYNTHESIS AND RECYCLING
metric value
setSize 11
pMANOVA 0.0724
p.adjustMANOVA 0.221
s.dist 0.468
s.LPS 0.285
s.OVA 0.371
p.LPS 0.102
p.OVA 0.033



Top 20 genes
Gene LPS OVA
Oplah 8182 8275
Cndp2 6183 7886
Gss 6638 7249
Ggt1 5048 4890
Chac1 7841 913

Click HERE to show all gene set members

All member genes
LPS OVA
Chac1 7841 913
Chac2 -2451 -1916
Cndp2 6183 7886
Gclc -3284 -4189
Gclm -5390 1212
Ggct -624 7254
Ggt1 5048 4890
Ggt5 -47 7072
Ggt7 3284 -2797
Gss 6638 7249
Oplah 8182 8275



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.4            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] highr_0.11              later_1.3.2             DelayedArray_0.30.1    
## [28] BiocParallel_1.38.0     parallel_4.4.0          R6_2.5.1               
## [31] bslib_0.7.0             stringi_1.8.4           RColorBrewer_1.1-3     
## [34] jquerylib_0.1.4         Rcpp_1.0.12             assertthat_0.2.1       
## [37] knitr_1.47              httpuv_1.6.15           Matrix_1.7-0           
## [40] tidyselect_1.2.1        rstudioapi_0.16.0       abind_1.4-5            
## [43] yaml_2.3.8              codetools_0.2-20        lattice_0.22-6         
## [46] plyr_1.8.9              withr_3.0.0             shiny_1.8.1.1          
## [49] evaluate_0.23           polyclip_1.10-6         ggstats_0.6.0          
## [52] xml2_1.3.6              pillar_1.9.0            KernSmooth_2.23-24     
## [55] generics_0.1.3          munsell_0.5.1           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [61] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [64] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [70] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [73] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [76] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [79] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [82] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report