date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik -0.3304181
0610009E02Rik 0.7596333
0610009L18Rik -1.2521412
0610010K14Rik 0.4193627
0610012G03Rik 1.4462155
0610030E20Rik -0.2426628

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17078
duplicated_genes_present 0
num_profile_genes_in_sets 8370
num_profile_genes_not_in_sets 8708

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 425
num_genesets_included 1179

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 7.45e-06 0.628 5.72e-04
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.28e-04 0.590 5.96e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.23e-05 0.579 7.25e-04
CGMP EFFECTS 15 1.52e-04 -0.565 4.73e-03
REDUCTION OF CYTOSOLIC CA LEVELS 11 1.33e-03 -0.559 2.12e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 5.99e-05 -0.518 2.21e-03
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 2.23e-05 0.511 1.10e-03
P75NTR REGULATES AXONOGENESIS 10 6.88e-03 -0.494 6.59e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.10e-03 -0.476 8.01e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.37e-03 0.470 4.02e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 1.08e-02 -0.444 9.12e-02
GAP JUNCTION ASSEMBLY 21 5.68e-04 0.434 1.12e-02
IRE1ALPHA ACTIVATES CHAPERONES 50 4.02e-07 0.414 7.94e-05
GLYCOGEN STORAGE DISEASES 12 1.42e-02 0.409 1.07e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 1.43e-05 -0.402 8.01e-04
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 4.16e-05 0.395 1.82e-03
AGGREPHAGY 35 5.81e-05 0.393 2.21e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 5.45e-08 0.387 2.14e-05
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.63e-02 0.385 1.16e-01
SODIUM CALCIUM EXCHANGERS 10 3.53e-02 -0.384 1.96e-01
INTRAFLAGELLAR TRANSPORT 51 2.07e-06 0.384 2.44e-04
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 7.27e-04 0.383 1.32e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.81e-02 -0.382 1.65e-01
XENOBIOTICS 10 3.78e-02 -0.379 2.07e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 2.96e-02 -0.379 1.72e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.86e-02 -0.378 2.09e-01
SIGNALING BY FGFR4 IN DISEASE 10 3.95e-02 -0.376 2.12e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.96e-03 -0.373 2.85e-02
MET ACTIVATES RAP1 AND RAC1 10 4.22e-02 -0.371 2.21e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.23e-04 -0.370 3.93e-03
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 2.04e-02 0.358 1.34e-01
HDR THROUGH MMEJ ALT NHEJ 10 5.03e-02 -0.357 2.35e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 1.73e-02 -0.355 1.18e-01
CYTOSOLIC TRNA AMINOACYLATION 24 3.02e-03 0.350 3.79e-02
COHESIN LOADING ONTO CHROMATIN 10 5.55e-02 -0.350 2.51e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 3.02e-02 0.347 1.75e-01
MATURATION OF NUCLEOPROTEIN 10 5.86e-02 -0.345 2.63e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 2.17e-02 -0.342 1.38e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 8.81e-03 0.338 7.86e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 6.44e-02 -0.338 2.79e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 1.41e-02 0.334 1.07e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 6.93e-03 0.333 6.59e-02
DISEASES OF CARBOHYDRATE METABOLISM 28 2.48e-03 0.330 3.22e-02
KERATAN SULFATE DEGRADATION 12 5.18e-02 0.324 2.39e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 4.72e-05 0.323 1.99e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.60e-04 0.322 4.73e-03
KERATAN SULFATE BIOSYNTHESIS 24 6.40e-03 0.322 6.39e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 7.93e-02 -0.320 3.15e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.77e-05 0.319 2.21e-03
RA BIOSYNTHESIS PATHWAY 12 5.55e-02 0.319 2.51e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 7.45e-06 0.628000 5.72e-04
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.28e-04 0.590000 5.96e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.23e-05 0.579000 7.25e-04
CGMP EFFECTS 15 1.52e-04 -0.565000 4.73e-03
REDUCTION OF CYTOSOLIC CA LEVELS 11 1.33e-03 -0.559000 2.12e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 5.99e-05 -0.518000 2.21e-03
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 2.23e-05 0.511000 1.10e-03
P75NTR REGULATES AXONOGENESIS 10 6.88e-03 -0.494000 6.59e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.10e-03 -0.476000 8.01e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.37e-03 0.470000 4.02e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 1.08e-02 -0.444000 9.12e-02
GAP JUNCTION ASSEMBLY 21 5.68e-04 0.434000 1.12e-02
IRE1ALPHA ACTIVATES CHAPERONES 50 4.02e-07 0.414000 7.94e-05
GLYCOGEN STORAGE DISEASES 12 1.42e-02 0.409000 1.07e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 1.43e-05 -0.402000 8.01e-04
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 4.16e-05 0.395000 1.82e-03
AGGREPHAGY 35 5.81e-05 0.393000 2.21e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 5.45e-08 0.387000 2.14e-05
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.63e-02 0.385000 1.16e-01
SODIUM CALCIUM EXCHANGERS 10 3.53e-02 -0.384000 1.96e-01
INTRAFLAGELLAR TRANSPORT 51 2.07e-06 0.384000 2.44e-04
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 7.27e-04 0.383000 1.32e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.81e-02 -0.382000 1.65e-01
XENOBIOTICS 10 3.78e-02 -0.379000 2.07e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 2.96e-02 -0.379000 1.72e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.86e-02 -0.378000 2.09e-01
SIGNALING BY FGFR4 IN DISEASE 10 3.95e-02 -0.376000 2.12e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.96e-03 -0.373000 2.85e-02
MET ACTIVATES RAP1 AND RAC1 10 4.22e-02 -0.371000 2.21e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.23e-04 -0.370000 3.93e-03
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 2.04e-02 0.358000 1.34e-01
HDR THROUGH MMEJ ALT NHEJ 10 5.03e-02 -0.357000 2.35e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 1.73e-02 -0.355000 1.18e-01
CYTOSOLIC TRNA AMINOACYLATION 24 3.02e-03 0.350000 3.79e-02
COHESIN LOADING ONTO CHROMATIN 10 5.55e-02 -0.350000 2.51e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 3.02e-02 0.347000 1.75e-01
MATURATION OF NUCLEOPROTEIN 10 5.86e-02 -0.345000 2.63e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 2.17e-02 -0.342000 1.38e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 8.81e-03 0.338000 7.86e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 6.44e-02 -0.338000 2.79e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 1.41e-02 0.334000 1.07e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 6.93e-03 0.333000 6.59e-02
DISEASES OF CARBOHYDRATE METABOLISM 28 2.48e-03 0.330000 3.22e-02
KERATAN SULFATE DEGRADATION 12 5.18e-02 0.324000 2.39e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 4.72e-05 0.323000 1.99e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.60e-04 0.322000 4.73e-03
KERATAN SULFATE BIOSYNTHESIS 24 6.40e-03 0.322000 6.39e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 7.93e-02 -0.320000 3.15e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.77e-05 0.319000 2.21e-03
RA BIOSYNTHESIS PATHWAY 12 5.55e-02 0.319000 2.51e-01
KERATAN SULFATE KERATIN METABOLISM 30 2.56e-03 0.318000 3.29e-02
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 4.82e-02 -0.316000 2.29e-01
METABOLISM OF STEROID HORMONES 22 1.07e-02 0.314000 9.12e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.24e-05 0.311000 1.10e-03
PHASE 0 RAPID DEPOLARISATION 30 3.21e-03 -0.311000 3.98e-02
PROLONGED ERK ACTIVATION EVENTS 14 4.43e-02 -0.310000 2.22e-01
MITOCHONDRIAL TRANSLATION 93 2.36e-07 0.310000 6.94e-05
STABILIZATION OF P53 54 8.10e-05 0.310000 2.65e-03
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 1.44e-02 -0.309000 1.07e-01
ASPARTATE AND ASPARAGINE METABOLISM 10 9.17e-02 -0.308000 3.49e-01
HEDGEHOG LIGAND BIOGENESIS 61 3.40e-05 0.307000 1.59e-03
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.84e-02 0.305000 1.23e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 2.54e-02 -0.304000 1.54e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.16e-02 0.304000 9.65e-02
TRNA AMINOACYLATION 42 7.30e-04 0.301000 1.32e-02
PREGNENOLONE BIOSYNTHESIS 12 7.14e-02 0.301000 2.99e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 5.17e-02 -0.300000 2.39e-01
DEGRADATION OF AXIN 53 1.62e-04 0.300000 4.73e-03
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 3.51e-04 0.298000 8.12e-03
EUKARYOTIC TRANSLATION ELONGATION 87 1.59e-06 0.298000 2.25e-04
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 7.99e-05 0.297000 2.65e-03
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 15 4.72e-02 0.296000 2.29e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.58e-02 -0.295000 1.55e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 9.15e-02 -0.294000 3.49e-01
HEME SIGNALING 45 6.84e-04 -0.293000 1.28e-02
FCERI MEDIATED CA 2 MOBILIZATION 26 9.89e-03 -0.292000 8.64e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 2.08e-02 -0.291000 1.35e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 2.11e-02 -0.291000 1.35e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 2.46e-04 0.288000 6.18e-03
HS GAG DEGRADATION 21 2.23e-02 0.288000 1.41e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.53e-02 -0.286000 1.10e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 1.01e-01 -0.286000 3.69e-01
CHOLESTEROL BIOSYNTHESIS 24 1.53e-02 0.286000 1.10e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.05e-01 0.283000 3.77e-01
LONG TERM POTENTIATION 23 1.98e-02 -0.281000 1.32e-01
PARASITE INFECTION 55 3.25e-04 -0.280000 7.73e-03
GAP JUNCTION TRAFFICKING AND REGULATION 33 5.47e-03 0.279000 5.69e-02
JOSEPHIN DOMAIN DUBS 11 1.10e-01 0.278000 3.85e-01
ENDOSOMAL VACUOLAR PATHWAY 11 1.10e-01 -0.278000 3.85e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 4.73e-02 -0.278000 2.29e-01
GLUCONEOGENESIS 27 1.26e-02 0.278000 1.01e-01
DEGRADATION OF DVL 55 3.80e-04 0.277000 8.60e-03
ERBB2 REGULATES CELL MOTILITY 14 7.28e-02 -0.277000 3.03e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 5.52e-02 -0.277000 2.51e-01
DSCAM INTERACTIONS 10 1.31e-01 -0.276000 4.23e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 6.46e-02 0.276000 2.79e-01
SHC1 EVENTS IN EGFR SIGNALING 11 1.14e-01 -0.275000 3.95e-01
OLFACTORY SIGNALING PATHWAY 25 1.80e-02 -0.273000 1.21e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 6.73e-02 -0.273000 2.86e-01
ZINC TRANSPORTERS 16 5.98e-02 -0.272000 2.67e-01
SIGNALING BY LEPTIN 10 1.38e-01 0.271000 4.35e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 4.13e-02 -0.270000 2.17e-01
TRANSCRIPTIONAL REGULATION BY MECP2 59 3.28e-04 -0.270000 7.73e-03
PCP CE PATHWAY 89 1.05e-05 0.270000 7.15e-04
HEDGEHOG OFF STATE 106 1.72e-06 0.269000 2.25e-04
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 10 1.42e-01 -0.268000 4.37e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 8.31e-02 -0.268000 3.27e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 3.41e-02 0.267000 1.93e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 3.99e-04 0.267000 8.88e-03
SIGNALING BY ERBB2 IN CANCER 25 2.11e-02 -0.267000 1.35e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 5.07e-04 0.266000 1.07e-02
METABOLISM OF FAT SOLUBLE VITAMINS 35 6.79e-03 0.264000 6.59e-02
METAL ION SLC TRANSPORTERS 25 2.26e-02 -0.263000 1.42e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.52e-01 -0.262000 4.47e-01
SIGNALING BY BMP 25 2.38e-02 -0.261000 1.46e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.65e-04 0.261000 4.73e-03
CA DEPENDENT EVENTS 36 6.87e-03 -0.260000 6.59e-02
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 4.56e-02 -0.258000 2.26e-01
TRANSLATION 286 6.58e-14 0.258000 7.76e-11
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 4.60e-02 -0.258000 2.26e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 7.48e-02 -0.257000 3.08e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 40 4.90e-03 0.257000 5.35e-02
AMINE LIGAND BINDING RECEPTORS 29 1.69e-02 -0.256000 1.16e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.38e-02 0.256000 1.46e-01
MITOCHONDRIAL PROTEIN IMPORT 63 4.49e-04 0.256000 9.76e-03
METABOLISM OF POLYAMINES 57 8.64e-04 0.255000 1.52e-02
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 1.62e-01 -0.255000 4.64e-01
TIE2 SIGNALING 17 6.92e-02 -0.255000 2.92e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.12e-01 0.255000 3.91e-01
HSF1 ACTIVATION 25 2.87e-02 0.253000 1.67e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 5.25e-04 0.253000 1.09e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 6.39e-02 0.252000 2.78e-01
G PROTEIN MEDIATED EVENTS 52 1.66e-03 -0.252000 2.50e-02
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 1.70e-02 -0.252000 1.16e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 7.76e-06 0.251000 5.72e-04
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 1.18e-01 -0.251000 3.98e-01
PEXOPHAGY 11 1.51e-01 0.250000 4.46e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 1.35e-01 -0.249000 4.28e-01
UNFOLDED PROTEIN RESPONSE UPR 86 7.18e-05 0.248000 2.49e-03
DAG AND IP3 SIGNALING 40 6.93e-03 -0.247000 6.59e-02
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 1.24e-01 -0.247000 4.07e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 1.11e-03 0.245000 1.82e-02
HSF1 DEPENDENT TRANSACTIVATION 33 1.48e-02 0.245000 1.09e-01
PYRIMIDINE SALVAGE 10 1.81e-01 0.244000 4.86e-01
ATTENUATION PHASE 23 4.40e-02 0.243000 2.22e-01
POTASSIUM CHANNELS 91 7.07e-05 -0.241000 2.49e-03
RHO GTPASES ACTIVATE IQGAPS 24 4.11e-02 0.241000 2.17e-01
RORA ACTIVATES GENE EXPRESSION 18 7.71e-02 -0.241000 3.11e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 1.34e-01 -0.240000 4.28e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 1.51e-01 0.239000 4.46e-01
SELENOAMINO ACID METABOLISM 109 1.76e-05 0.238000 9.42e-04
SIGNALING BY HIPPO 20 6.54e-02 -0.238000 2.81e-01
G1 S DNA DAMAGE CHECKPOINTS 65 9.60e-04 0.237000 1.62e-02
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 1.55e-01 -0.237000 4.51e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 2.42e-04 0.236000 6.18e-03
CROSSLINKING OF COLLAGEN FIBRILS 16 1.05e-01 0.234000 3.77e-01
VLDLR INTERNALISATION AND DEGRADATION 12 1.60e-01 0.234000 4.59e-01
INTERLEUKIN 10 SIGNALING 19 7.80e-02 -0.234000 3.12e-01
GAB1 SIGNALOSOME 14 1.30e-01 -0.234000 4.23e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 1.29e-02 0.233000 1.02e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 1.14e-03 0.232000 1.84e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 7.85e-03 0.232000 7.12e-02
GRB2 EVENTS IN ERBB2 SIGNALING 15 1.23e-01 -0.230000 4.05e-01
INTERACTION BETWEEN L1 AND ANKYRINS 28 3.52e-02 -0.230000 1.96e-01
RMTS METHYLATE HISTONE ARGININES 45 7.65e-03 0.230000 7.04e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 7.52e-02 -0.230000 3.08e-01
ACTIVATION OF RAC1 13 1.53e-01 -0.229000 4.47e-01
DEADENYLATION OF MRNA 25 4.78e-02 -0.229000 2.29e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 1.67e-02 -0.227000 1.16e-01
DARPP 32 EVENTS 23 6.34e-02 -0.224000 2.77e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 8.36e-02 -0.224000 3.27e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 2.21e-01 -0.223000 5.33e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 2.37e-03 0.223000 3.16e-02
CARDIAC CONDUCTION 109 6.00e-05 -0.223000 2.21e-03
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.02e-03 -0.222000 1.70e-02
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 4.24e-02 -0.222000 2.21e-01
TNFR2 NON CANONICAL NF KB PATHWAY 79 6.68e-04 0.222000 1.27e-02
MITOTIC TELOPHASE CYTOKINESIS 13 1.67e-01 -0.221000 4.66e-01
RNA POLYMERASE III CHAIN ELONGATION 18 1.05e-01 0.221000 3.77e-01
HDMS DEMETHYLATE HISTONES 28 4.37e-02 -0.220000 2.22e-01
FCERI MEDIATED MAPK ACTIVATION 28 4.38e-02 -0.220000 2.22e-01
NEUROTRANSMITTER RELEASE CYCLE 49 7.71e-03 -0.220000 7.04e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.07e-01 -0.220000 5.15e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 2.17e-04 0.220000 5.82e-03
INTERFERON GAMMA SIGNALING 77 8.65e-04 -0.220000 1.52e-02
INSULIN PROCESSING 24 6.32e-02 -0.219000 2.77e-01
RECYCLING PATHWAY OF L1 40 1.67e-02 0.219000 1.16e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 1.43e-01 -0.219000 4.37e-01
MISMATCH REPAIR 14 1.58e-01 0.218000 4.54e-01
NUCLEOTIDE SALVAGE 21 8.39e-02 0.218000 3.27e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.10e-01 0.218000 3.85e-01
CA2 PATHWAY 58 4.20e-03 -0.217000 4.72e-02
LATE ENDOSOMAL MICROAUTOPHAGY 32 3.35e-02 0.217000 1.92e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 1.22e-02 -0.216000 9.95e-02
SELECTIVE AUTOPHAGY 72 1.59e-03 0.215000 2.44e-02
RHOJ GTPASE CYCLE 54 6.25e-03 -0.215000 6.30e-02
SIGNALING BY HEDGEHOG 141 1.09e-05 0.215000 7.15e-04
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 1.50e-01 0.214000 4.46e-01
INTERLEUKIN 6 SIGNALING 10 2.41e-01 0.214000 5.53e-01
SIGNALING BY PDGFR IN DISEASE 20 9.74e-02 -0.214000 3.62e-01
RHOQ GTPASE CYCLE 58 4.84e-03 -0.214000 5.33e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 3.20e-06 0.214000 3.14e-04
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 1.70e-02 -0.210000 1.16e-01
TIGHT JUNCTION INTERACTIONS 17 1.34e-01 -0.210000 4.28e-01
ADHERENS JUNCTIONS INTERACTIONS 30 4.65e-02 -0.210000 2.27e-01
ACTIVATION OF SMO 16 1.46e-01 0.210000 4.42e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 5.52e-04 0.210000 1.10e-02
SIGNALING BY FLT3 FUSION PROTEINS 19 1.15e-01 -0.209000 3.95e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 9.74e-02 0.209000 3.62e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 2.53e-01 0.209000 5.62e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 24 7.66e-02 0.209000 3.10e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.49e-01 -0.209000 4.46e-01
REGULATION OF RAS BY GAPS 66 3.44e-03 0.208000 4.06e-02
CELLULAR RESPONSE TO HYPOXIA 72 2.37e-03 0.207000 3.16e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 2.19e-01 0.205000 5.31e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.45e-03 -0.205000 3.21e-02
INTERFERON SIGNALING 165 5.69e-06 -0.205000 4.79e-04
CELL CELL JUNCTION ORGANIZATION 49 1.32e-02 -0.205000 1.03e-01
HIV ELONGATION ARREST AND RECOVERY 32 4.51e-02 0.205000 2.24e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 2.64e-01 -0.204000 5.72e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 8.34e-02 -0.204000 3.27e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 1.86e-01 -0.204000 4.90e-01
ABC TRANSPORTER DISORDERS 70 3.24e-03 0.204000 3.98e-02
PLASMA LIPOPROTEIN CLEARANCE 28 6.24e-02 0.203000 2.77e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 2.24e-01 0.203000 5.37e-01
SIGNALING BY FGFR1 IN DISEASE 33 4.42e-02 -0.202000 2.22e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 5.16e-02 -0.202000 2.39e-01
RRNA PROCESSING 194 1.27e-06 0.202000 2.14e-04
EUKARYOTIC TRANSLATION INITIATION 114 1.98e-04 0.202000 5.43e-03
MRNA SPLICING MINOR PATHWAY 52 1.21e-02 0.201000 9.95e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 6.27e-02 0.200000 2.77e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 7.83e-02 -0.200000 3.12e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 65 5.49e-03 0.199000 5.69e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 2.15e-01 -0.199000 5.26e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.55e-01 0.198000 5.62e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 1.85e-01 0.198000 4.89e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 4.96e-02 -0.197000 2.32e-01
RAP1 SIGNALLING 15 1.86e-01 -0.197000 4.89e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 2.82e-01 -0.197000 5.91e-01
BUDDING AND MATURATION OF HIV VIRION 27 7.74e-02 0.196000 3.11e-01
HEDGEHOG ON STATE 82 2.17e-03 0.196000 3.04e-02
KINESINS 47 2.04e-02 0.196000 1.34e-01
HS GAG BIOSYNTHESIS 29 6.90e-02 0.195000 2.92e-01
REGULATION OF TNFR1 SIGNALING 34 4.93e-02 0.195000 2.32e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 1.32e-01 0.195000 4.27e-01
NONSENSE MEDIATED DECAY NMD 109 4.55e-04 0.194000 9.76e-03
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 5.72e-02 -0.194000 2.57e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 2.44e-01 0.194000 5.56e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 1.98e-03 0.193000 2.85e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 7.74e-02 0.193000 3.11e-01
SULFUR AMINO ACID METABOLISM 22 1.18e-01 0.192000 3.98e-01
EARLY PHASE OF HIV LIFE CYCLE 13 2.30e-01 -0.192000 5.43e-01
DISEASES OF METABOLISM 199 3.19e-06 0.192000 3.14e-04
GABA RECEPTOR ACTIVATION 54 1.50e-02 -0.191000 1.09e-01
ION HOMEOSTASIS 49 2.05e-02 -0.191000 1.34e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 7.47e-02 -0.191000 3.08e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 9.16e-02 -0.191000 3.49e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 1.53e-02 -0.191000 1.10e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 58 1.24e-02 -0.190000 1.01e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 1.42e-01 -0.190000 4.37e-01
RAB GERANYLGERANYLATION 57 1.34e-02 -0.189000 1.03e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.91e-01 -0.189000 4.95e-01
COMPLEX I BIOGENESIS 56 1.45e-02 0.189000 1.08e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 2.89e-03 0.188000 3.66e-02
INTERFERON ALPHA BETA SIGNALING 56 1.49e-02 -0.188000 1.09e-01
RUNX3 REGULATES NOTCH SIGNALING 13 2.41e-01 -0.188000 5.53e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.57e-01 -0.188000 4.54e-01
COLLAGEN FORMATION 79 4.00e-03 0.187000 4.62e-02
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 2.42e-01 0.187000 5.54e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 2.82e-01 0.187000 5.91e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 2.83e-01 0.187000 5.91e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 7.64e-02 0.187000 3.10e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 4.10e-02 -0.187000 2.17e-01
MYOGENESIS 25 1.06e-01 -0.187000 3.77e-01
SIGNALING BY ERYTHROPOIETIN 24 1.14e-01 -0.187000 3.93e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 2.27e-01 0.186000 5.39e-01
UCH PROTEINASES 90 2.28e-03 0.186000 3.13e-02
THE PHOTOTRANSDUCTION CASCADE 21 1.40e-01 -0.186000 4.37e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 3.62e-03 -0.186000 4.22e-02
POLYMERASE SWITCHING 14 2.30e-01 0.185000 5.43e-01
LDL CLEARANCE 16 2.02e-01 0.184000 5.09e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 3.18e-01 0.182000 6.21e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.22e-01 -0.182000 5.33e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 7.01e-02 -0.182000 2.94e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 15 2.23e-01 0.182000 5.36e-01
SIGNALING BY VEGF 103 1.46e-03 -0.182000 2.26e-02
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 4.09e-03 0.181000 4.64e-02
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 8.70e-02 0.181000 3.36e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 1.74e-01 0.180000 4.75e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 317 4.08e-08 0.180000 2.14e-05
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.82e-01 -0.179000 5.91e-01
PROTEIN FOLDING 90 3.32e-03 0.179000 4.02e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.30e-01 -0.179000 5.43e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 2.58e-02 -0.179000 1.55e-01
MUCOPOLYSACCHARIDOSES 11 3.06e-01 0.178000 6.05e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 10 3.29e-01 -0.178000 6.27e-01
REGULATION OF IFNA SIGNALING 12 2.86e-01 0.178000 5.94e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 2.67e-02 0.178000 1.57e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 16 2.19e-01 -0.178000 5.31e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 2.88e-01 -0.177000 5.95e-01
CHAPERONE MEDIATED AUTOPHAGY 21 1.60e-01 0.177000 4.59e-01
FCERI MEDIATED NF KB ACTIVATION 77 7.28e-03 0.177000 6.81e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 1.82e-01 0.177000 4.86e-01
OPIOID SIGNALLING 87 4.53e-03 -0.176000 5.04e-02
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 2.91e-01 0.176000 5.95e-01
SYNTHESIS OF PE 13 2.72e-01 0.176000 5.84e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 3.36e-01 -0.176000 6.29e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.92e-01 -0.176000 5.95e-01
THE NLRP3 INFLAMMASOME 15 2.42e-01 0.174000 5.54e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 1.29e-02 -0.174000 1.02e-01
EFFECTS OF PIP2 HYDROLYSIS 27 1.17e-01 -0.174000 3.98e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 2.96e-01 0.174000 5.98e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 1.68e-01 0.174000 4.67e-01
ASSEMBLY OF THE HIV VIRION 16 2.31e-01 0.173000 5.43e-01
SIGNALING BY NTRK2 TRKB 24 1.43e-01 -0.173000 4.37e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 2.47e-01 0.173000 5.59e-01
ENOS ACTIVATION 11 3.23e-01 -0.172000 6.22e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 2.49e-01 0.172000 5.59e-01
OTHER SEMAPHORIN INTERACTIONS 19 1.95e-01 -0.172000 4.99e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 2.08e-01 -0.171000 5.18e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 9.97e-02 -0.171000 3.68e-01
AUTOPHAGY 139 5.48e-04 0.170000 1.10e-02
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 7.16e-03 0.170000 6.75e-02
IRAK4 DEFICIENCY TLR2 4 13 2.91e-01 -0.169000 5.95e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 21 1.80e-01 -0.169000 4.86e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 1.81e-01 0.169000 4.86e-01
BIOTIN TRANSPORT AND METABOLISM 11 3.33e-01 0.169000 6.27e-01
DAP12 INTERACTIONS 31 1.05e-01 -0.168000 3.77e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 1.54e-01 0.168000 4.50e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 2.94e-01 0.168000 5.96e-01
CARNITINE METABOLISM 14 2.79e-01 0.167000 5.90e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 1.49e-01 0.167000 4.46e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 2.99e-01 -0.167000 6.00e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 1.89e-01 -0.166000 4.91e-01
RAC2 GTPASE CYCLE 87 7.66e-03 -0.165000 7.04e-02
INTERLEUKIN 1 SIGNALING 96 5.12e-03 0.165000 5.49e-02
CD209 DC SIGN SIGNALING 18 2.25e-01 -0.165000 5.37e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 2.02e-01 -0.165000 5.09e-01
FORMATION OF THE CORNIFIED ENVELOPE 30 1.18e-01 0.165000 3.98e-01
KERATINIZATION 30 1.18e-01 0.165000 3.98e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 1.72e-01 -0.165000 4.72e-01
CITRIC ACID CYCLE TCA CYCLE 22 1.82e-01 0.165000 4.86e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.15e-01 -0.164000 5.26e-01
CELLULAR RESPONSE TO STARVATION 146 6.31e-04 0.164000 1.22e-02
FGFR1 MUTANT RECEPTOR ACTIVATION 26 1.50e-01 -0.163000 4.46e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.75e-01 0.163000 4.78e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 1.08e-02 0.163000 9.12e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 3.09e-01 -0.163000 6.09e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 9.57e-02 0.163000 3.60e-01
PYRUVATE METABOLISM 27 1.43e-01 -0.163000 4.38e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 14 2.92e-01 -0.163000 5.95e-01
PI METABOLISM 79 1.25e-02 -0.163000 1.01e-01
PECAM1 INTERACTIONS 12 3.31e-01 -0.162000 6.27e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 2.77e-01 0.162000 5.89e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 3.75e-01 -0.162000 6.73e-01
DAP12 SIGNALING 24 1.69e-01 -0.162000 4.69e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 1.69e-01 0.162000 4.69e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 37 8.95e-02 0.161000 3.45e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 9.13e-02 -0.160000 3.49e-01
DNA METHYLATION 22 1.93e-01 0.160000 4.98e-01
FGFR2 ALTERNATIVE SPLICING 25 1.67e-01 0.160000 4.66e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 1.12e-01 0.160000 3.91e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.40e-02 0.160000 1.93e-01
DISEASES OF GLYCOSYLATION 125 2.11e-03 0.159000 2.99e-02
NEUREXINS AND NEUROLIGINS 54 4.29e-02 -0.159000 2.22e-01
GLYCOSAMINOGLYCAN METABOLISM 114 3.37e-03 0.159000 4.02e-02
NUCLEAR IMPORT OF REV PROTEIN 32 1.20e-01 -0.159000 4.00e-01
LAGGING STRAND SYNTHESIS 20 2.19e-01 0.159000 5.31e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 3.23e-01 0.158000 6.22e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 3.87e-01 0.158000 6.79e-01
BASE EXCISION REPAIR AP SITE FORMATION 31 1.29e-01 0.158000 4.21e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.38e-03 0.157000 3.16e-02
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 2.48e-01 -0.157000 5.59e-01
FANCONI ANEMIA PATHWAY 36 1.03e-01 0.157000 3.76e-01
RESPIRATORY ELECTRON TRANSPORT 102 6.10e-03 0.157000 6.20e-02
CILIUM ASSEMBLY 191 1.89e-04 0.157000 5.32e-03
EPHA MEDIATED GROWTH CONE COLLAPSE 29 1.45e-01 -0.157000 4.39e-01
FOXO MEDIATED TRANSCRIPTION 58 3.94e-02 -0.156000 2.12e-01
RESOLUTION OF D LOOP STRUCTURES 30 1.40e-01 -0.156000 4.37e-01
P75NTR SIGNALS VIA NF KB 16 2.81e-01 0.156000 5.91e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 1.88e-01 0.155000 4.91e-01
KILLING MECHANISMS 11 3.73e-01 0.155000 6.72e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 3.33e-01 0.155000 6.27e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 25 1.80e-01 0.155000 4.86e-01
METABOLISM OF FOLATE AND PTERINES 15 3.00e-01 0.155000 6.01e-01
RAC3 GTPASE CYCLE 90 1.13e-02 -0.155000 9.42e-02
PI 3K CASCADE FGFR2 16 2.85e-01 -0.154000 5.93e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 34 1.20e-01 0.154000 4.00e-01
RHOBTB1 GTPASE CYCLE 23 2.01e-01 -0.154000 5.09e-01
NEURONAL SYSTEM 369 4.04e-07 -0.154000 7.94e-05
GOLGI TO ER RETROGRADE TRANSPORT 119 4.06e-03 0.153000 4.64e-02
ANTIMICROBIAL PEPTIDES 18 2.63e-01 0.152000 5.72e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 16 2.91e-01 0.152000 5.95e-01
TRAFFICKING OF AMPA RECEPTORS 31 1.43e-01 -0.152000 4.37e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 1.25e-01 -0.152000 4.09e-01
SIGNALING BY NOTCH4 83 1.70e-02 0.152000 1.16e-01
MUSCLE CONTRACTION 162 8.77e-04 -0.152000 1.52e-02
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.94e-01 -0.152000 5.95e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 1.16e-01 -0.151000 3.98e-01
GLYCOGEN METABOLISM 25 1.92e-01 0.151000 4.98e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 14 3.29e-01 0.151000 6.27e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 1.30e-01 0.150000 4.22e-01
METABOLISM OF CARBOHYDRATES 258 3.51e-05 0.150000 1.59e-03
PROTEIN LOCALIZATION 156 1.42e-03 0.148000 2.23e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 2.00e-01 -0.148000 5.09e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 2.91e-01 -0.148000 5.95e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 1.92e-01 -0.148000 4.96e-01
PLATELET HOMEOSTASIS 79 2.30e-02 -0.148000 1.44e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 3.96e-01 -0.148000 6.87e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.75e-01 0.148000 6.73e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 7.51e-02 0.147000 3.08e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 3.81e-01 -0.146000 6.74e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 1.35e-01 -0.146000 4.28e-01
ANTIGEN PROCESSING CROSS PRESENTATION 97 1.33e-02 0.146000 1.03e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 4.41e-02 0.146000 2.22e-01
INFLAMMASOMES 19 2.73e-01 0.145000 5.86e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 3.86e-01 0.145000 6.77e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 3.69e-01 0.144000 6.67e-01
RAC1 GTPASE CYCLE 178 9.53e-04 -0.144000 1.62e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 42 1.08e-01 0.143000 3.82e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 4.81e-02 0.143000 2.29e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 1.85e-01 -0.142000 4.89e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 1.51e-01 -0.142000 4.46e-01
PHOSPHORYLATION OF THE APC C 17 3.10e-01 0.142000 6.10e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 2.85e-01 -0.142000 5.93e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 4.16e-01 0.142000 6.99e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 2.41e-01 -0.141000 5.53e-01
PEPTIDE LIGAND BINDING RECEPTORS 118 8.26e-03 0.141000 7.44e-02
ERK MAPK TARGETS 22 2.54e-01 -0.140000 5.62e-01
RHOU GTPASE CYCLE 33 1.63e-01 -0.140000 4.64e-01
DISEASES OF DNA REPAIR 11 4.22e-01 0.140000 7.05e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 3.33e-01 0.140000 6.27e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 4.23e-01 0.139000 7.06e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 2.10e-01 -0.139000 5.19e-01
SCAVENGING BY CLASS A RECEPTORS 14 3.69e-01 0.139000 6.67e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 3.22e-01 -0.139000 6.22e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 1.50e-01 -0.139000 4.46e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 2.26e-02 0.138000 1.42e-01
CIRCADIAN CLOCK 68 4.92e-02 -0.138000 2.32e-01
SIGNALING BY EGFR IN CANCER 22 2.63e-01 -0.138000 5.72e-01
PLATELET CALCIUM HOMEOSTASIS 27 2.16e-01 -0.137000 5.27e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.10e-01 -0.137000 6.99e-01
HYALURONAN UPTAKE AND DEGRADATION 11 4.30e-01 0.137000 7.11e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.27e-01 -0.137000 6.27e-01
GLUCOSE METABOLISM 80 3.43e-02 0.137000 1.93e-01
ERYTHROPOIETIN ACTIVATES RAS 13 3.93e-01 -0.137000 6.85e-01
NETRIN 1 SIGNALING 49 9.83e-02 -0.137000 3.64e-01
INWARDLY RECTIFYING K CHANNELS 32 1.82e-01 -0.136000 4.86e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 5.10e-03 0.136000 5.49e-02
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 17 3.32e-01 -0.136000 6.27e-01
CYTOPROTECTION BY HMOX1 119 1.06e-02 0.136000 9.12e-02
GLYCOGEN SYNTHESIS 14 3.80e-01 0.135000 6.74e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 4.59e-01 0.135000 7.35e-01
INTERLEUKIN 7 SIGNALING 19 3.07e-01 0.135000 6.06e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.81e-01 0.135000 6.74e-01
DNA DAMAGE RECOGNITION IN GG NER 38 1.50e-01 0.135000 4.46e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 4.80e-02 -0.135000 2.29e-01
DNA REPLICATION PRE INITIATION 79 3.84e-02 0.135000 2.09e-01
PROCESSING OF SMDT1 16 3.52e-01 0.134000 6.51e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 32 1.89e-01 0.134000 4.91e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 2.13e-01 0.134000 5.23e-01
CD28 DEPENDENT VAV1 PATHWAY 11 4.43e-01 -0.134000 7.19e-01
PRE NOTCH PROCESSING IN GOLGI 17 3.42e-01 0.133000 6.37e-01
MICRORNA MIRNA BIOGENESIS 24 2.61e-01 0.133000 5.71e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 2.83e-01 0.132000 5.92e-01
PI 3K CASCADE FGFR4 12 4.29e-01 -0.132000 7.10e-01
SIGNALING BY FGFR2 IIIA TM 19 3.20e-01 0.132000 6.22e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 2.21e-01 0.131000 5.33e-01
SPRY REGULATION OF FGF SIGNALING 16 3.64e-01 0.131000 6.61e-01
PI 3K CASCADE FGFR3 13 4.15e-01 -0.131000 6.99e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 4.50e-02 0.130000 2.24e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 3.79e-02 -0.130000 2.07e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 2.02e-01 -0.130000 5.09e-01
CRISTAE FORMATION 31 2.12e-01 0.130000 5.21e-01
POLO LIKE KINASE MEDIATED EVENTS 14 4.02e-01 0.129000 6.92e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 70 6.21e-02 0.129000 2.76e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 94 3.08e-02 -0.129000 1.77e-01
EPHRIN SIGNALING 19 3.30e-01 0.129000 6.27e-01
TELOMERE MAINTENANCE 80 4.64e-02 0.129000 2.27e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 151 6.61e-03 0.128000 6.55e-02
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 1.04e-01 -0.128000 3.77e-01
ACYL CHAIN REMODELLING OF PE 16 3.81e-01 -0.127000 6.74e-01
ORC1 REMOVAL FROM CHROMATIN 67 7.35e-02 0.126000 3.05e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 94 3.49e-02 0.126000 1.96e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 9.62e-02 0.125000 3.60e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 2.70e-01 0.125000 5.82e-01
SEPARATION OF SISTER CHROMATIDS 166 5.50e-03 0.125000 5.69e-02
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 4.35e-01 -0.125000 7.11e-01
SIGNALING BY ERBB2 48 1.35e-01 -0.125000 4.28e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 3.22e-01 0.125000 6.22e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 2.39e-01 -0.124000 5.53e-01
SIGNALING BY ROBO RECEPTORS 205 2.26e-03 0.124000 3.13e-02
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 172 5.31e-03 0.123000 5.64e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 92 4.13e-02 0.123000 2.17e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 3.81e-01 -0.123000 6.74e-01
PURINE SALVAGE 12 4.61e-01 0.123000 7.37e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.42e-01 0.123000 4.37e-01
SYNTHESIS OF PA 29 2.54e-01 0.122000 5.62e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 4.63e-01 -0.122000 7.38e-01
COSTIMULATION BY THE CD28 FAMILY 50 1.35e-01 -0.122000 4.28e-01
GLYCOLYSIS 66 8.65e-02 0.122000 3.36e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 22 3.22e-01 -0.122000 6.22e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 3.70e-01 0.122000 6.68e-01
BASE EXCISION REPAIR 58 1.09e-01 0.122000 3.84e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 3.58e-01 0.122000 6.55e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 2.49e-01 0.122000 5.59e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 4.00e-01 -0.121000 6.91e-01
INSULIN RECEPTOR SIGNALLING CASCADE 44 1.65e-01 -0.121000 4.66e-01
RHOF GTPASE CYCLE 40 1.86e-01 -0.121000 4.89e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 4.34e-01 -0.121000 7.11e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 4.70e-01 -0.121000 7.38e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 3.78e-01 -0.120000 6.74e-01
G PROTEIN BETA GAMMA SIGNALLING 31 2.48e-01 -0.120000 5.59e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.20e-01 -0.120000 6.22e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.92e-01 -0.120000 7.58e-01
SIALIC ACID METABOLISM 32 2.43e-01 -0.119000 5.54e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 4.24e-01 0.119000 7.06e-01
METABOLISM OF AMINE DERIVED HORMONES 10 5.14e-01 0.119000 7.70e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 4.25e-01 -0.119000 7.06e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 4.31e-02 -0.119000 2.22e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 3.14e-01 0.119000 6.15e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 52 1.40e-01 0.118000 4.37e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 4.97e-01 0.118000 7.60e-01
IRS MEDIATED SIGNALLING 39 2.01e-01 -0.118000 5.09e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 4.61e-01 0.118000 7.37e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 3.51e-01 -0.118000 6.50e-01
APOPTOTIC EXECUTION PHASE 45 1.72e-01 -0.118000 4.72e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.00e-01 -0.117000 6.01e-01
REGULATION OF IFNG SIGNALING 13 4.65e-01 0.117000 7.38e-01
DNA REPLICATION 121 2.65e-02 0.117000 1.57e-01
REGULATION OF FZD BY UBIQUITINATION 20 3.66e-01 0.117000 6.62e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 4.20e-01 0.117000 7.03e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 241 1.91e-03 -0.116000 2.82e-02
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 6.48e-02 0.115000 2.79e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 11 5.09e-01 0.115000 7.65e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 5.09e-01 -0.115000 7.65e-01
INFLUENZA INFECTION 145 1.69e-02 0.115000 1.16e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 61 1.22e-01 -0.115000 4.03e-01
MHC CLASS II ANTIGEN PRESENTATION 102 4.59e-02 0.114000 2.26e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 2.64e-01 -0.114000 5.73e-01
NUCLEAR ENVELOPE BREAKDOWN 49 1.67e-01 -0.114000 4.67e-01
CLEC7A DECTIN 1 SIGNALING 95 5.53e-02 0.114000 2.51e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 1.97e-01 -0.114000 5.04e-01
SIGNALING BY KIT IN DISEASE 20 3.81e-01 -0.113000 6.74e-01
EPHB MEDIATED FORWARD SIGNALING 42 2.05e-01 -0.113000 5.12e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 1.55e-01 0.113000 4.51e-01
RNA POLYMERASE I TRANSCRIPTION 69 1.05e-01 0.113000 3.77e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 1.06e-01 0.113000 3.77e-01
TELOMERE EXTENSION BY TELOMERASE 22 3.62e-01 0.112000 6.59e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 5.02e-01 0.112000 7.64e-01
TNF SIGNALING 43 2.04e-01 0.112000 5.11e-01
RHOBTB GTPASE CYCLE 35 2.52e-01 -0.112000 5.62e-01
METHYLATION 12 5.05e-01 0.111000 7.64e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 1.66e-01 0.111000 4.66e-01
LAMININ INTERACTIONS 29 3.03e-01 -0.111000 6.04e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 180 1.07e-02 -0.110000 9.12e-02
REPRESSION OF WNT TARGET GENES 14 4.74e-01 0.110000 7.43e-01
INTERLEUKIN 1 FAMILY SIGNALING 121 3.62e-02 0.110000 2.00e-01
CELL JUNCTION ORGANIZATION 73 1.03e-01 -0.110000 3.77e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 3.82e-01 0.110000 6.74e-01
GLYCOSPHINGOLIPID METABOLISM 38 2.40e-01 0.110000 5.53e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 4.34e-01 -0.110000 7.11e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 1.94e-01 0.109000 4.99e-01
SLC TRANSPORTER DISORDERS 76 1.00e-01 -0.109000 3.68e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 4.96e-01 -0.109000 7.60e-01
FORMATION OF APOPTOSOME 10 5.51e-01 -0.109000 7.89e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 2.65e-01 0.109000 5.73e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 4.51e-01 -0.109000 7.29e-01
RETINOID CYCLE DISEASE EVENTS 10 5.52e-01 0.109000 7.89e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 4.12e-01 0.109000 6.99e-01
COLLAGEN CHAIN TRIMERIZATION 40 2.36e-01 0.108000 5.48e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 4.14e-01 -0.108000 6.99e-01
ASPARAGINE N LINKED GLYCOSYLATION 286 1.68e-03 0.108000 2.50e-02
PI 3K CASCADE FGFR1 15 4.69e-01 -0.108000 7.38e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 22 3.82e-01 -0.108000 6.74e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.20e-01 -0.107000 7.74e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 62 1.44e-01 0.107000 4.39e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 4.73e-01 -0.107000 7.41e-01
METABOLISM OF RNA 644 4.05e-06 0.107000 3.67e-04
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 5.40e-01 -0.107000 7.82e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 4.34e-01 -0.107000 7.11e-01
MAPK6 MAPK4 SIGNALING 83 9.34e-02 0.107000 3.53e-01
LGI ADAM INTERACTIONS 14 4.90e-01 -0.107000 7.58e-01
RHOV GTPASE CYCLE 32 2.97e-01 -0.106000 5.99e-01
REGULATION OF BETA CELL DEVELOPMENT 28 3.33e-01 -0.106000 6.27e-01
MITOTIC METAPHASE AND ANAPHASE 207 8.87e-03 0.106000 7.86e-02
DISEASES OF PROGRAMMED CELL DEATH 56 1.72e-01 0.105000 4.72e-01
VXPX CARGO TARGETING TO CILIUM 19 4.28e-01 0.105000 7.10e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 3.04e-01 -0.105000 6.05e-01
MITOTIC G2 G2 M PHASES 184 1.44e-02 0.105000 1.07e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 5.30e-01 -0.105000 7.79e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.98e-01 0.105000 7.61e-01
METABOLISM OF NUCLEOTIDES 92 8.38e-02 0.104000 3.27e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 3.01e-01 -0.104000 6.01e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 5.70e-01 -0.104000 8.02e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 58 1.73e-01 -0.104000 4.72e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 3.19e-01 0.103000 6.22e-01
CELL CELL COMMUNICATION 106 6.63e-02 -0.103000 2.83e-01
FATTY ACYL COA BIOSYNTHESIS 32 3.12e-01 -0.103000 6.13e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 4.91e-01 -0.103000 7.58e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 1.72e-01 0.103000 4.72e-01
RHO GTPASES ACTIVATE PAKS 21 4.16e-01 -0.103000 6.99e-01
SUMOYLATION 165 2.45e-02 -0.102000 1.49e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 2.50e-01 -0.101000 5.61e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 1.65e-01 -0.101000 4.66e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 5.79e-01 0.101000 8.07e-01
VISUAL PHOTOTRANSDUCTION 63 1.66e-01 0.101000 4.66e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 64 1.66e-01 0.100000 4.66e-01
RHOG GTPASE CYCLE 73 1.39e-01 -0.100000 4.37e-01
EXTENSION OF TELOMERES 49 2.26e-01 0.100000 5.38e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 3.28e-01 0.100000 6.27e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.38e-02 0.100000 1.46e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 5.33e-01 -0.099900 7.79e-01
TBC RABGAPS 43 2.59e-01 0.099600 5.69e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 4.09e-01 0.099400 6.99e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 5.52e-01 0.099100 7.89e-01
MITOPHAGY 29 3.56e-01 0.099000 6.55e-01
GLUTATHIONE CONJUGATION 29 3.57e-01 0.098800 6.55e-01
PTEN REGULATION 133 4.97e-02 0.098700 2.32e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 5.38e-01 0.098600 7.81e-01
GPVI MEDIATED ACTIVATION CASCADE 31 3.44e-01 -0.098200 6.41e-01
HIV TRANSCRIPTION ELONGATION 42 2.71e-01 0.098100 5.84e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 5.40e-01 0.098100 7.82e-01
MRNA SPLICING 188 2.06e-02 0.098000 1.34e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 12 5.57e-01 -0.098000 7.92e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 5.92e-01 -0.097900 8.17e-01
RHOD GTPASE CYCLE 50 2.32e-01 -0.097800 5.43e-01
ION TRANSPORT BY P TYPE ATPASES 49 2.39e-01 -0.097200 5.53e-01
CELLULAR HEXOSE TRANSPORT 11 5.79e-01 0.096700 8.07e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 2.75e-01 0.096300 5.87e-01
PRC2 METHYLATES HISTONES AND DNA 31 3.54e-01 0.096300 6.53e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 3.26e-01 -0.096000 6.25e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 1.18e-01 -0.095800 3.98e-01
SIGNALING BY NODAL 15 5.22e-01 -0.095500 7.74e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 3.37e-01 -0.095100 6.32e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 3.94e-01 -0.094800 6.85e-01
SIGNALING BY ACTIVIN 12 5.71e-01 -0.094500 8.02e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 4.76e-01 0.094400 7.45e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 5.59e-01 0.093600 7.93e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 6.09e-01 -0.093300 8.22e-01
METABOLISM OF COFACTORS 19 4.83e-01 0.093000 7.53e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.05e-01 -0.092700 6.05e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 2.27e-01 0.092600 5.39e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 5.97e-01 -0.092200 8.17e-01
SIGNALING BY ERBB4 57 2.31e-01 -0.091700 5.43e-01
CS DS DEGRADATION 14 5.53e-01 0.091500 7.89e-01
HCMV INFECTION 105 1.06e-01 0.091400 3.77e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 3.65e-01 0.091200 6.61e-01
HYALURONAN METABOLISM 15 5.43e-01 0.090800 7.84e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 5.30e-01 0.090600 7.79e-01
RND1 GTPASE CYCLE 38 3.35e-01 -0.090400 6.29e-01
RHOB GTPASE CYCLE 67 2.03e-01 -0.090100 5.09e-01
G ALPHA I SIGNALLING EVENTS 206 2.61e-02 -0.090100 1.55e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 4.57e-01 0.089600 7.33e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 6.25e-01 -0.089300 8.27e-01
TRIGLYCERIDE CATABOLISM 14 5.64e-01 -0.089100 7.95e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 4.15e-01 0.089100 6.99e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 6.26e-01 0.089100 8.27e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 5.04e-01 -0.088600 7.64e-01
CD28 CO STIMULATION 31 3.93e-01 -0.088600 6.85e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 4.29e-01 0.087900 7.10e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 45 3.08e-01 -0.087900 6.06e-01
STIMULI SENSING CHANNELS 76 1.85e-01 -0.087900 4.89e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 4.66e-01 -0.087900 7.38e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 179 4.29e-02 0.087800 2.22e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 5.21e-01 0.087400 7.74e-01
PROTEIN METHYLATION 17 5.33e-01 0.087400 7.79e-01
BIOLOGICAL OXIDATIONS 127 9.20e-02 0.086600 3.49e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 604 2.97e-04 0.086500 7.30e-03
METABOLISM OF VITAMINS AND COFACTORS 156 6.29e-02 0.086400 2.77e-01
AMYLOID FIBER FORMATION 60 2.48e-01 0.086300 5.59e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 69 2.16e-01 -0.086300 5.26e-01
SIGNALING BY SCF KIT 41 3.40e-01 -0.086200 6.34e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 5.05e-01 0.086200 7.64e-01
MEIOTIC RECOMBINATION 40 3.46e-01 -0.086200 6.43e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 6.21e-01 -0.086000 8.26e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 2.75e-01 -0.085200 5.87e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.95e-01 -0.085200 8.17e-01
HCMV EARLY EVENTS 82 1.83e-01 0.085100 4.87e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 283 1.40e-02 0.085000 1.07e-01
G2 M DNA DAMAGE CHECKPOINT 66 2.36e-01 -0.084400 5.48e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 6.44e-01 -0.084400 8.36e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 6.44e-01 -0.084400 8.36e-01
INTERLEUKIN 27 SIGNALING 10 6.44e-01 -0.084300 8.36e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 4.34e-01 -0.083900 7.11e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 5.27e-01 -0.083800 7.78e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.04e-01 0.083800 5.11e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 3.32e-01 -0.083500 6.27e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 5.18e-01 0.083500 7.73e-01
METABOLISM OF STEROIDS 116 1.20e-01 0.083500 4.00e-01
MEIOSIS 66 2.41e-01 -0.083500 5.53e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 1.35e-01 -0.083300 4.28e-01
REPRODUCTION 79 2.02e-01 -0.083200 5.09e-01
RNA POLYMERASE III TRANSCRIPTION 41 3.57e-01 0.083100 6.55e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 5.78e-01 -0.083000 8.06e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 6.05e-01 0.082800 8.22e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 4.67e-01 0.082400 7.38e-01
TCR SIGNALING 100 1.55e-01 0.082300 4.51e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 4.95e-01 0.082300 7.60e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 5.45e-02 0.082100 2.50e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 139 9.61e-02 0.081800 3.60e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 5.16e-01 0.081800 7.73e-01
SIGNALING BY FGFR1 43 3.56e-01 -0.081400 6.55e-01
TRNA PROCESSING IN THE NUCLEUS 56 2.93e-01 -0.081200 5.95e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 4.91e-01 0.081200 7.58e-01
ESR MEDIATED SIGNALING 169 6.93e-02 -0.081100 2.92e-01
FERTILIZATION 13 6.14e-01 -0.080700 8.22e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 5.66e-01 0.080400 7.97e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 2.91e-01 -0.079500 5.95e-01
RNA POLYMERASE II TRANSCRIPTION 1090 1.15e-05 -0.079300 7.15e-04
INTERLEUKIN 6 FAMILY SIGNALING 20 5.41e-01 0.079000 7.82e-01
RAS PROCESSING 24 5.03e-01 0.078900 7.64e-01
FLT3 SIGNALING 36 4.16e-01 -0.078400 6.99e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 86 2.10e-01 -0.078300 5.19e-01
IRAK1 RECRUITS IKK COMPLEX 14 6.13e-01 0.078200 8.22e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 6.13e-01 0.078000 8.22e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 4.92e-01 0.077900 7.58e-01
PI3K AKT SIGNALING IN CANCER 88 2.10e-01 -0.077400 5.19e-01
SIGNALING BY FGFR2 63 2.89e-01 0.077200 5.95e-01
G1 S SPECIFIC TRANSCRIPTION 26 4.96e-01 0.077200 7.60e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 20 5.54e-01 0.076500 7.89e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 67 2.79e-01 0.076500 5.90e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 2.25e-01 0.076200 5.37e-01
ELASTIC FIBRE FORMATION 38 4.17e-01 0.076100 6.99e-01
UNWINDING OF DNA 12 6.50e-01 -0.075800 8.38e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 2.33e-01 -0.075700 5.45e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 1.81e-01 0.075000 4.86e-01
LYSOSOME VESICLE BIOGENESIS 32 4.64e-01 0.074800 7.38e-01
RESOLUTION OF ABASIC SITES AP SITES 37 4.33e-01 0.074500 7.11e-01
GABA B RECEPTOR ACTIVATION 40 4.16e-01 -0.074400 6.99e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 6.07e-01 -0.074400 8.22e-01
LYSINE CATABOLISM 11 6.72e-01 0.073800 8.56e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 6.88e-01 -0.073400 8.61e-01
RNA POLYMERASE I PROMOTER ESCAPE 49 3.76e-01 0.073100 6.73e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 6.03e-01 0.072900 8.22e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 6.64e-01 0.072400 8.50e-01
NEGATIVE REGULATION OF FLT3 14 6.39e-01 0.072400 8.34e-01
CRMPS IN SEMA3A SIGNALING 16 6.16e-01 0.072400 8.22e-01
NICOTINATE METABOLISM 25 5.31e-01 -0.072400 7.79e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 4.47e-01 -0.072300 7.24e-01
PKMTS METHYLATE HISTONE LYSINES 49 3.82e-01 -0.072200 6.74e-01
HOST INTERACTIONS OF HIV FACTORS 124 1.67e-01 0.072000 4.66e-01
PEROXISOMAL PROTEIN IMPORT 57 3.48e-01 0.071800 6.47e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 48 3.89e-01 0.071800 6.81e-01
DNA DAMAGE BYPASS 46 4.00e-01 -0.071800 6.91e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 26 5.28e-01 0.071500 7.78e-01
CALNEXIN CALRETICULIN CYCLE 26 5.29e-01 0.071400 7.78e-01
NONHOMOLOGOUS END JOINING NHEJ 44 4.15e-01 -0.071100 6.99e-01
SIGNAL TRANSDUCTION BY L1 21 5.74e-01 -0.070800 8.04e-01
DNA STRAND ELONGATION 32 4.88e-01 0.070800 7.58e-01
EGFR DOWNREGULATION 28 5.18e-01 -0.070500 7.73e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 5.95e-01 0.070500 8.17e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 33 4.85e-01 0.070200 7.55e-01
RHO GTPASE CYCLE 426 1.33e-02 -0.070100 1.03e-01
TOLL LIKE RECEPTOR CASCADES 137 1.58e-01 -0.070000 4.54e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 23 5.62e-01 0.069900 7.95e-01
P38MAPK EVENTS 12 6.75e-01 0.069900 8.56e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 541 5.61e-03 -0.069900 5.75e-02
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 4.34e-01 -0.069800 7.11e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 90 2.54e-01 -0.069600 5.62e-01
NEDDYLATION 219 7.66e-02 0.069500 3.10e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 4.20e-01 0.069400 7.03e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 6.95e-01 -0.068300 8.63e-01
C TYPE LECTIN RECEPTORS CLRS 113 2.11e-01 0.068100 5.21e-01
INSULIN RECEPTOR RECYCLING 20 5.98e-01 0.068100 8.18e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 20 6.00e-01 0.067700 8.20e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 49 4.14e-01 0.067500 6.99e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 4.55e-01 -0.066700 7.31e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 6.77e-01 0.066700 8.56e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 3.64e-01 0.066700 6.61e-01
PLASMA LIPOPROTEIN REMODELING 17 6.35e-01 0.066600 8.31e-01
RHOBTB2 GTPASE CYCLE 23 5.82e-01 -0.066300 8.09e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 6.93e-01 0.065800 8.63e-01
SIGNALING BY EGFR 47 4.35e-01 -0.065800 7.11e-01
G ALPHA Z SIGNALLING EVENTS 46 4.41e-01 -0.065700 7.17e-01
INTERLEUKIN 17 SIGNALING 67 3.53e-01 -0.065600 6.53e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 4.13e-01 -0.065600 6.99e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 7.06e-01 0.065600 8.68e-01
EXTRACELLULAR MATRIX ORGANIZATION 243 8.15e-02 0.065000 3.23e-01
MITOCHONDRIAL BIOGENESIS 92 2.82e-01 -0.065000 5.91e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 48 4.38e-01 -0.064700 7.15e-01
CHROMOSOME MAINTENANCE 103 2.59e-01 0.064400 5.69e-01
RND2 GTPASE CYCLE 38 4.93e-01 -0.064300 7.59e-01
MITOTIC PROPHASE 96 2.77e-01 -0.064200 5.89e-01
SIGNALING BY NOTCH3 48 4.42e-01 -0.064200 7.17e-01
MRNA CAPPING 29 5.50e-01 0.064100 7.89e-01
SIGNALING BY NOTCH 189 1.30e-01 0.064000 4.22e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 7.27e-01 -0.063900 8.78e-01
PEROXISOMAL LIPID METABOLISM 26 5.74e-01 0.063700 8.04e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 141 1.93e-01 0.063600 4.98e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 95 2.87e-01 0.063300 5.94e-01
OTHER INTERLEUKIN SIGNALING 20 6.26e-01 0.063000 8.27e-01
RECEPTOR MEDIATED MITOPHAGY 11 7.18e-01 -0.063000 8.70e-01
CDC42 GTPASE CYCLE 153 1.79e-01 -0.063000 4.86e-01
SARS COV 1 INFECTION 48 4.52e-01 0.062700 7.29e-01
INTERLEUKIN 37 SIGNALING 18 6.46e-01 0.062600 8.36e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 6.29e-01 -0.062400 8.29e-01
SIGNALLING TO ERKS 33 5.36e-01 -0.062300 7.80e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 3.97e-01 -0.062200 6.88e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 5.07e-01 -0.062200 7.65e-01
NEUTROPHIL DEGRANULATION 386 3.63e-02 0.062200 2.00e-01
REGULATION OF KIT SIGNALING 16 6.67e-01 -0.062200 8.52e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 6.06e-01 0.062100 8.22e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 12 7.10e-01 -0.062100 8.70e-01
RHOC GTPASE CYCLE 73 3.61e-01 -0.061900 6.59e-01
BASIGIN INTERACTIONS 22 6.15e-01 -0.061900 8.22e-01
NUCLEAR SIGNALING BY ERBB4 31 5.53e-01 0.061600 7.89e-01
SIGNALING BY NOTCH2 32 5.47e-01 -0.061500 7.89e-01
O LINKED GLYCOSYLATION OF MUCINS 41 4.97e-01 0.061300 7.60e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 192 1.45e-01 -0.061100 4.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 5.63e-01 0.061100 7.95e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 6.54e-01 0.061000 8.41e-01
MAP2K AND MAPK ACTIVATION 36 5.27e-01 -0.061000 7.78e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 2.75e-01 0.060800 5.87e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 4.53e-01 -0.060800 7.30e-01
INTERLEUKIN 35 SIGNALLING 10 7.40e-01 -0.060700 8.88e-01
G PROTEIN ACTIVATION 23 6.15e-01 0.060700 8.22e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 6.15e-01 0.060600 8.22e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 4.68e-01 -0.060600 7.38e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 5.94e-01 0.060400 8.17e-01
SARS COV 2 INFECTION 65 4.01e-01 0.060300 6.91e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 5.50e-01 -0.060100 7.89e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 6.52e-01 -0.059700 8.40e-01
TRIGLYCERIDE BIOSYNTHESIS 10 7.46e-01 0.059100 8.92e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.19e-01 0.058900 3.98e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 29 5.83e-01 0.058900 8.10e-01
AMINO ACIDS REGULATE MTORC1 51 4.68e-01 0.058800 7.38e-01
ERKS ARE INACTIVATED 13 7.14e-01 -0.058800 8.70e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 4.65e-01 0.058600 7.38e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 106 2.98e-01 0.058600 5.99e-01
NRAGE SIGNALS DEATH THROUGH JNK 55 4.55e-01 -0.058300 7.31e-01
HIV INFECTION 220 1.37e-01 0.058300 4.33e-01
SIGNALING BY THE B CELL RECEPTOR BCR 104 3.07e-01 0.058100 6.06e-01
SURFACTANT METABOLISM 16 6.88e-01 0.058000 8.61e-01
NEPHRIN FAMILY INTERACTIONS 23 6.30e-01 -0.058000 8.29e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 3.28e-01 0.057800 6.27e-01
TRANSLESION SYNTHESIS BY POLK 17 6.81e-01 -0.057700 8.56e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 7.11e-01 -0.057200 8.70e-01
BILE ACID AND BILE SALT METABOLISM 25 6.22e-01 -0.057000 8.26e-01
AQUAPORIN MEDIATED TRANSPORT 40 5.36e-01 -0.056500 7.80e-01
INOSITOL PHOSPHATE METABOLISM 47 5.03e-01 -0.056500 7.64e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 7.17e-01 0.055900 8.70e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 6.24e-01 -0.055600 8.27e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 7.61e-01 0.055500 8.96e-01
HOMOLOGY DIRECTED REPAIR 107 3.22e-01 -0.055500 6.22e-01
G2 M CHECKPOINTS 133 2.70e-01 0.055400 5.82e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 5.76e-01 0.055400 8.05e-01
SARS COV INFECTIONS 140 2.59e-01 0.055300 5.69e-01
DISEASES OF IMMUNE SYSTEM 24 6.41e-01 -0.055100 8.35e-01
GPCR LIGAND BINDING 281 1.13e-01 0.055000 3.92e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 4.62e-01 -0.054900 7.37e-01
RUNX2 REGULATES BONE DEVELOPMENT 28 6.16e-01 -0.054800 8.22e-01
REGULATION OF SIGNALING BY CBL 22 6.57e-01 -0.054700 8.44e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 6.12e-01 -0.054500 8.22e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 5.14e-01 -0.052900 7.70e-01
ION CHANNEL TRANSPORT 142 2.79e-01 -0.052700 5.90e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 5.61e-01 -0.052400 7.95e-01
EPH EPHRIN SIGNALING 92 3.85e-01 -0.052400 6.77e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 7.55e-01 0.052100 8.94e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 93 3.86e-01 -0.052000 6.77e-01
SIGNALING BY WNT IN CANCER 31 6.17e-01 -0.052000 8.22e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.67e-01 0.051800 8.52e-01
IRON UPTAKE AND TRANSPORT 51 5.24e-01 0.051600 7.75e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 6.14e-01 0.051500 8.22e-01
UB SPECIFIC PROCESSING PROTEASES 168 2.52e-01 0.051300 5.62e-01
SIGNALING BY NUCLEAR RECEPTORS 225 1.89e-01 -0.051000 4.91e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 6.81e-01 -0.050600 8.56e-01
SIGNALING BY NTRKS 130 3.21e-01 -0.050500 6.22e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 179 2.48e-01 0.050100 5.59e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 7.37e-01 0.050100 8.87e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 6.48e-01 0.049900 8.37e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 6.31e-01 -0.049800 8.30e-01
PROTEIN UBIQUITINATION 70 4.72e-01 -0.049700 7.41e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 107 3.76e-01 0.049600 6.73e-01
FATTY ACID METABOLISM 145 3.05e-01 0.049400 6.05e-01
S PHASE 153 2.93e-01 0.049300 5.95e-01
INFECTIOUS DISEASE 737 2.36e-02 0.049200 1.46e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 7.89e-01 0.049000 9.15e-01
ACYL CHAIN REMODELLING OF PC 16 7.35e-01 -0.049000 8.86e-01
SIGNALING BY INSULIN RECEPTOR 63 5.06e-01 -0.048400 7.65e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 25 6.78e-01 -0.048000 8.56e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 5.88e-01 0.047800 8.14e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 4.78e-01 -0.047700 7.47e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.58e-01 -0.047500 8.95e-01
MEIOTIC SYNAPSIS 42 5.96e-01 0.047300 8.17e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 5.10e-01 0.047300 7.65e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 7.29e-01 -0.047200 8.80e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 105 4.06e-01 0.047000 6.96e-01
LEISHMANIA INFECTION 201 2.52e-01 -0.047000 5.62e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 7.53e-01 -0.046900 8.94e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 20 7.17e-01 0.046800 8.70e-01
COMPLEMENT CASCADE 25 6.86e-01 0.046700 8.61e-01
NICOTINAMIDE SALVAGING 16 7.48e-01 -0.046400 8.92e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 5.00e-01 -0.046300 7.63e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 199 2.64e-01 0.046000 5.72e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 7.92e-01 0.045800 9.17e-01
METALLOPROTEASE DUBS 27 6.80e-01 0.045800 8.56e-01
ONCOGENIC MAPK SIGNALING 77 4.89e-01 -0.045700 7.58e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 7.85e-01 -0.045500 9.14e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 7.40e-01 0.045200 8.88e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 5.36e-01 0.045100 7.80e-01
ONCOGENE INDUCED SENESCENCE 32 6.60e-01 0.045000 8.47e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 6.66e-01 -0.044800 8.51e-01
PHASE II CONJUGATION OF COMPOUNDS 62 5.48e-01 0.044200 7.89e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 6.76e-01 -0.044000 8.56e-01
STRIATED MUSCLE CONTRACTION 25 7.04e-01 -0.043900 8.65e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 6.96e-01 0.043500 8.63e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 5.93e-01 0.043300 8.17e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 6.87e-01 -0.043200 8.61e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 4.70e-01 -0.043200 7.38e-01
SYNDECAN INTERACTIONS 27 6.99e-01 0.043000 8.65e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 5.17e-01 0.043000 7.73e-01
DUAL INCISION IN TC NER 64 5.55e-01 0.042700 7.90e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 467 1.17e-01 -0.042500 3.98e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 6.28e-01 0.042300 8.28e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 7.03e-01 -0.041700 8.65e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 7.95e-01 -0.041600 9.18e-01
MET PROMOTES CELL MOTILITY 39 6.54e-01 -0.041500 8.41e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 12 8.04e-01 0.041400 9.19e-01
COLLAGEN DEGRADATION 51 6.11e-01 0.041200 8.22e-01
ACYL CHAIN REMODELLING OF PG 10 8.22e-01 -0.041100 9.26e-01
DERMATAN SULFATE BIOSYNTHESIS 11 8.14e-01 0.041000 9.23e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 3.93e-01 0.041000 6.85e-01
POTENTIAL THERAPEUTICS FOR SARS 77 5.35e-01 0.040900 7.80e-01
SIGNALING BY RETINOIC ACID 32 6.89e-01 0.040800 8.62e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 7.53e-01 0.040600 8.94e-01
CELLULAR SENESCENCE 144 4.06e-01 0.040200 6.96e-01
RND3 GTPASE CYCLE 37 6.74e-01 -0.040000 8.56e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 7.76e-01 -0.040000 9.05e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 7.17e-01 0.039600 8.70e-01
HEMOSTASIS 473 1.42e-01 -0.039500 4.37e-01
PROGRAMMED CELL DEATH 185 3.58e-01 0.039300 6.55e-01
SIGNALLING TO RAS 19 7.69e-01 0.039000 9.02e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 7.64e-01 -0.038800 8.98e-01
PENTOSE PHOSPHATE PATHWAY 13 8.09e-01 0.038600 9.21e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 8.10e-01 -0.038600 9.21e-01
RHO GTPASE EFFECTORS 253 2.93e-01 -0.038500 5.95e-01
ACYL CHAIN REMODELLING OF PS 14 8.05e-01 0.038200 9.19e-01
APOPTOSIS 163 4.03e-01 0.038000 6.93e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.48e-01 -0.037700 7.24e-01
M PHASE 342 2.33e-01 0.037600 5.45e-01
ESTROGEN DEPENDENT GENE EXPRESSION 105 5.08e-01 -0.037400 7.65e-01
NUCLEOBASE BIOSYNTHESIS 15 8.02e-01 0.037400 9.19e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 7.52e-01 0.037300 8.94e-01
SIGNALING BY GPCR 497 1.59e-01 -0.037000 4.57e-01
VIRAL MESSENGER RNA SYNTHESIS 42 6.78e-01 -0.037000 8.56e-01
NUCLEOBASE CATABOLISM 31 7.23e-01 0.036800 8.76e-01
SENSORY PROCESSING OF SOUND 62 6.17e-01 0.036700 8.22e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 7.47e-01 0.036600 8.92e-01
NGF STIMULATED TRANSCRIPTION 37 7.01e-01 -0.036500 8.65e-01
TRANSCRIPTION OF THE HIV GENOME 67 6.08e-01 0.036300 8.22e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 28 7.41e-01 -0.036100 8.88e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 5.96e-01 -0.035900 8.17e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 7.83e-01 -0.035600 9.13e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 6.44e-01 0.035500 8.36e-01
FRS MEDIATED FGFR4 SIGNALING 14 8.19e-01 0.035400 9.24e-01
NUCLEOTIDE EXCISION REPAIR 109 5.24e-01 0.035300 7.75e-01
REGULATION OF INSULIN SECRETION 72 6.06e-01 -0.035200 8.22e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 7.39e-01 0.035200 8.88e-01
TP53 REGULATES METABOLIC GENES 85 5.76e-01 -0.035100 8.05e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 8.03e-01 0.035000 9.19e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 8.08e-01 0.035000 9.21e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 7.92e-01 0.035000 9.17e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 7.13e-01 -0.035000 8.70e-01
SIGNALING BY FGFR 74 6.05e-01 0.034800 8.22e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 7.88e-01 -0.034800 9.15e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 5.48e-01 0.034400 7.89e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 46 6.90e-01 0.034000 8.62e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.39e-01 -0.033800 9.37e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 631 1.50e-01 -0.033700 4.46e-01
MET ACTIVATES PTK2 SIGNALING 29 7.56e-01 0.033400 8.95e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 6.33e-01 -0.033200 8.31e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 7.74e-01 0.033200 9.04e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 7.72e-01 0.032900 9.04e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 7.04e-01 -0.032800 8.65e-01
KETONE BODY METABOLISM 10 8.60e-01 0.032200 9.43e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 7.00e-01 -0.032100 8.65e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 8.30e-01 0.032000 9.32e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 8.56e-01 0.031600 9.43e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.33e-01 -0.031500 9.33e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 7.48e-01 0.031400 8.92e-01
INTEGRIN CELL SURFACE INTERACTIONS 71 6.49e-01 -0.031300 8.38e-01
ANCHORING FIBRIL FORMATION 14 8.41e-01 0.031000 9.37e-01
GP1B IX V ACTIVATION SIGNALLING 10 8.65e-01 -0.031000 9.43e-01
OXIDATIVE STRESS INDUCED SENESCENCE 80 6.34e-01 0.030800 8.31e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 8.13e-01 -0.030600 9.23e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 8.04e-01 0.029900 9.19e-01
SNRNP ASSEMBLY 51 7.12e-01 -0.029800 8.70e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 8.09e-01 0.029800 9.21e-01
ECM PROTEOGLYCANS 67 6.76e-01 0.029500 8.56e-01
SIGNALING BY FGFR IN DISEASE 55 7.08e-01 -0.029200 8.69e-01
SIGNALING BY PDGF 57 7.03e-01 0.029200 8.65e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 7.59e-01 -0.029200 8.95e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 6.40e-01 -0.029100 8.34e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 118 5.88e-01 0.028900 8.14e-01
RHOH GTPASE CYCLE 37 7.62e-01 -0.028800 8.96e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.94e-01 -0.028600 9.17e-01
COPII MEDIATED VESICLE TRANSPORT 66 6.94e-01 0.028000 8.63e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 7.68e-01 -0.028000 9.02e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 7.55e-01 0.027900 8.94e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 6.78e-01 -0.027800 8.56e-01
RHOA GTPASE CYCLE 142 5.74e-01 -0.027400 8.04e-01
TRIGLYCERIDE METABOLISM 24 8.17e-01 -0.027400 9.23e-01
INTRA GOLGI TRAFFIC 43 7.57e-01 -0.027300 8.95e-01
INTERLEUKIN 15 SIGNALING 12 8.70e-01 -0.027300 9.47e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 7.18e-01 -0.027200 8.70e-01
FRS MEDIATED FGFR1 SIGNALING 17 8.47e-01 0.027000 9.39e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 281 4.40e-01 -0.026800 7.16e-01
VESICLE MEDIATED TRANSPORT 611 2.60e-01 0.026800 5.69e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 8.03e-01 -0.026800 9.19e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 8.03e-01 0.026700 9.19e-01
INTEGRATION OF ENERGY METABOLISM 99 6.47e-01 0.026600 8.37e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 8.18e-01 0.026600 9.24e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 8.57e-01 -0.026100 9.43e-01
DEATH RECEPTOR SIGNALLING 133 6.10e-01 -0.025600 8.22e-01
FRS MEDIATED FGFR3 SIGNALING 15 8.64e-01 0.025500 9.43e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 6.80e-01 -0.025400 8.56e-01
METABOLISM OF PORPHYRINS 19 8.49e-01 -0.025300 9.39e-01
PYRIMIDINE CATABOLISM 10 8.91e-01 0.025100 9.57e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 8.86e-01 -0.024900 9.54e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 8.47e-01 -0.024900 9.39e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 8.83e-01 0.024600 9.52e-01
NCAM1 INTERACTIONS 41 7.89e-01 0.024200 9.15e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 8.50e-01 0.023800 9.39e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 7.24e-01 -0.023600 8.76e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 8.59e-01 0.023500 9.43e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 6.95e-01 -0.023400 8.63e-01
O LINKED GLYCOSYLATION 85 7.11e-01 0.023200 8.70e-01
PHOSPHOLIPID METABOLISM 185 5.89e-01 -0.023100 8.14e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 120 6.63e-01 0.023000 8.50e-01
RAF ACTIVATION 34 8.17e-01 -0.023000 9.23e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 26 8.42e-01 -0.022600 9.38e-01
RHO GTPASES ACTIVATE FORMINS 119 6.72e-01 0.022500 8.56e-01
CTLA4 INHIBITORY SIGNALING 20 8.63e-01 0.022300 9.43e-01
RHO GTPASES ACTIVATE KTN1 11 8.98e-01 -0.022200 9.59e-01
ENDOGENOUS STEROLS 21 8.62e-01 0.022000 9.43e-01
DNA REPAIR 292 5.22e-01 0.021800 7.74e-01
FRS MEDIATED FGFR2 SIGNALING 18 8.73e-01 -0.021700 9.49e-01
SIGNALING BY MET 75 7.47e-01 0.021600 8.92e-01
MYD88 INDEPENDENT TLR4 CASCADE 92 7.25e-01 -0.021300 8.76e-01
MITOTIC PROMETAPHASE 177 6.27e-01 -0.021200 8.28e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 8.52e-01 0.021100 9.40e-01
SEMAPHORIN INTERACTIONS 64 7.71e-01 0.021100 9.03e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 8.95e-01 0.021100 9.58e-01
SIGNALING BY WNT 270 5.58e-01 0.020800 7.92e-01
MEMBRANE TRAFFICKING 581 3.99e-01 0.020600 6.91e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 8.95e-01 0.020400 9.58e-01
CELL CYCLE CHECKPOINTS 242 5.86e-01 0.020300 8.13e-01
RET SIGNALING 37 8.33e-01 -0.020000 9.33e-01
PURINE CATABOLISM 16 8.91e-01 -0.019700 9.57e-01
DNA DOUBLE STRAND BREAK RESPONSE 53 8.05e-01 0.019600 9.19e-01
HDACS DEACETYLATE HISTONES 48 8.15e-01 0.019600 9.23e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 347 5.32e-01 -0.019600 7.79e-01
ADAPTIVE IMMUNE SYSTEM 601 4.15e-01 -0.019500 6.99e-01
NERVOUS SYSTEM DEVELOPMENT 550 4.36e-01 0.019500 7.11e-01
SMOOTH MUSCLE CONTRACTION 34 8.45e-01 0.019400 9.39e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 8.62e-01 -0.019400 9.43e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 7.03e-01 -0.019100 8.65e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 46 8.24e-01 -0.019000 9.27e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 8.39e-01 -0.018900 9.37e-01
CELL CYCLE MITOTIC 476 4.85e-01 0.018700 7.55e-01
PEPTIDE HORMONE METABOLISM 61 8.01e-01 -0.018600 9.19e-01
RHO GTPASES ACTIVATE CIT 18 8.92e-01 -0.018400 9.57e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 8.22e-01 -0.018300 9.26e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 9.13e-01 -0.018100 9.65e-01
RHO GTPASES ACTIVATE ROCKS 19 8.92e-01 0.018100 9.57e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 9.04e-01 0.018100 9.62e-01
RAB REGULATION OF TRAFFICKING 119 7.38e-01 0.017800 8.88e-01
G0 AND EARLY G1 25 8.78e-01 0.017700 9.52e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 7.58e-01 0.017600 8.95e-01
INTEGRIN SIGNALING 24 8.83e-01 -0.017400 9.52e-01
SPHINGOLIPID METABOLISM 80 7.89e-01 0.017300 9.15e-01
SIGNALING BY PTK6 50 8.34e-01 -0.017200 9.33e-01
INTERLEUKIN 12 FAMILY SIGNALING 44 8.48e-01 -0.016700 9.39e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 8.30e-01 0.016600 9.32e-01
PYROPTOSIS 21 8.96e-01 -0.016400 9.58e-01
INTERLEUKIN 12 SIGNALING 37 8.64e-01 0.016300 9.43e-01
DISEASES OF MITOTIC CELL CYCLE 37 8.65e-01 -0.016100 9.43e-01
GENE SILENCING BY RNA 84 8.02e-01 -0.015900 9.19e-01
HEME BIOSYNTHESIS 13 9.23e-01 -0.015500 9.70e-01
SIGNALING BY NTRK3 TRKC 17 9.14e-01 -0.015200 9.65e-01
SHC MEDIATED CASCADE FGFR4 12 9.28e-01 0.015100 9.73e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 8.80e-01 0.015000 9.52e-01
TRANSCRIPTIONAL REGULATION BY TP53 340 6.37e-01 -0.014900 8.33e-01
N GLYCAN ANTENNAE ELONGATION 15 9.20e-01 -0.014900 9.68e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 8.15e-01 0.014700 9.23e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 8.95e-01 -0.014500 9.58e-01
L1CAM INTERACTIONS 109 7.98e-01 -0.014200 9.19e-01
SIGNALING BY FGFR2 IN DISEASE 36 8.83e-01 -0.014200 9.52e-01
TRANSLESION SYNTHESIS BY POLH 19 9.15e-01 0.014200 9.65e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 39 8.82e-01 0.013700 9.52e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 6.92e-01 -0.013600 8.63e-01
AURKA ACTIVATION BY TPX2 71 8.44e-01 -0.013500 9.39e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 68 8.51e-01 0.013200 9.39e-01
PRE NOTCH EXPRESSION AND PROCESSING 65 8.59e-01 -0.012700 9.43e-01
SYNTHESIS OF PC 26 9.11e-01 0.012700 9.65e-01
MTORC1 MEDIATED SIGNALLING 24 9.15e-01 -0.012700 9.65e-01
PROCESSING AND ACTIVATION OF SUMO 10 9.45e-01 0.012700 9.81e-01
CELLULAR RESPONSE TO HEAT STRESS 94 8.36e-01 0.012400 9.35e-01
DUAL INCISION IN GG NER 40 8.97e-01 0.011800 9.58e-01
TRANSPORT OF SMALL MOLECULES 583 6.38e-01 -0.011400 8.34e-01
CHROMATIN MODIFYING ENZYMES 220 7.74e-01 -0.011300 9.04e-01
INNATE IMMUNE SYSTEM 781 6.12e-01 0.010700 8.22e-01
SIGNALING BY CSF3 G CSF 29 9.21e-01 0.010700 9.68e-01
PLATELET SENSITIZATION BY LDL 15 9.43e-01 0.010600 9.81e-01
REGULATED NECROSIS 46 9.01e-01 0.010600 9.61e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1221 5.62e-01 0.009940 7.95e-01
SIGNALING BY INTERLEUKINS 345 7.53e-01 0.009860 8.94e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 9.34e-01 0.009830 9.76e-01
SHC MEDIATED CASCADE FGFR1 15 9.48e-01 0.009690 9.81e-01
HATS ACETYLATE HISTONES 94 8.71e-01 0.009680 9.48e-01
SIGNALING BY NOTCH1 75 8.86e-01 -0.009590 9.54e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 9.37e-01 0.009520 9.78e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.57e-01 -0.009430 9.86e-01
SIGNAL AMPLIFICATION 31 9.28e-01 0.009320 9.73e-01
MITOTIC SPINDLE CHECKPOINT 97 8.76e-01 -0.009150 9.51e-01
METABOLISM OF LIPIDS 616 7.04e-01 0.009010 8.65e-01
SENSORY PERCEPTION 148 8.50e-01 0.009000 9.39e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 9.06e-01 -0.008750 9.64e-01
RHO GTPASES ACTIVATE PKNS 49 9.17e-01 -0.008640 9.66e-01
G ALPHA S SIGNALLING EVENTS 108 8.82e-01 0.008280 9.52e-01
ARACHIDONIC ACID METABOLISM 38 9.30e-01 -0.008200 9.73e-01
HCMV LATE EVENTS 67 9.10e-01 -0.007980 9.65e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 366 7.98e-01 -0.007810 9.19e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 34 9.40e-01 0.007480 9.79e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 76 9.11e-01 -0.007460 9.65e-01
NOD1 2 SIGNALING PATHWAY 34 9.40e-01 -0.007420 9.79e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 9.12e-01 0.007230 9.65e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.48e-01 0.007040 9.81e-01
FLT3 SIGNALING IN DISEASE 28 9.49e-01 0.006940 9.81e-01
PROLACTIN RECEPTOR SIGNALING 11 9.68e-01 -0.006930 9.91e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 224 8.65e-01 -0.006610 9.43e-01
CARGO CONCENTRATION IN THE ER 31 9.50e-01 0.006480 9.81e-01
CELL CYCLE 593 7.93e-01 0.006340 9.17e-01
PLATELET AGGREGATION PLUG FORMATION 32 9.51e-01 0.006320 9.81e-01
SIGNALING BY FGFR3 35 9.49e-01 -0.006200 9.81e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.61e-01 -0.006120 9.89e-01
MTOR SIGNALLING 40 9.47e-01 0.006040 9.81e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 9.30e-01 -0.005920 9.73e-01
TRP CHANNELS 20 9.64e-01 0.005830 9.89e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 9.63e-01 -0.005740 9.89e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 9.12e-01 0.005720 9.65e-01
CONDENSATION OF PROPHASE CHROMOSOMES 29 9.59e-01 0.005550 9.87e-01
SHC MEDIATED CASCADE FGFR3 13 9.74e-01 0.005260 9.93e-01
RHOBTB3 ATPASE CYCLE 10 9.77e-01 0.005170 9.94e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 9.75e-01 -0.004900 9.93e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 9.78e-01 0.004800 9.94e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 9.42e-01 0.004730 9.81e-01
HIV LIFE CYCLE 142 9.27e-01 0.004440 9.73e-01
DEUBIQUITINATION 242 9.06e-01 0.004400 9.64e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 63 9.52e-01 0.004390 9.82e-01
DEVELOPMENTAL BIOLOGY 822 8.40e-01 0.004180 9.37e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 9.64e-01 0.004120 9.89e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 9.81e-01 -0.003720 9.94e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 9.71e-01 -0.003650 9.93e-01
G ALPHA Q SIGNALLING EVENTS 166 9.36e-01 -0.003630 9.77e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 9.76e-01 -0.003480 9.94e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 52 9.68e-01 0.003230 9.91e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 9.68e-01 -0.003010 9.91e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 61 9.69e-01 -0.002880 9.91e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 9.82e-01 -0.002730 9.94e-01
SIGNALING BY FGFR4 33 9.79e-01 0.002630 9.94e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 9.79e-01 -0.002370 9.94e-01
PERK REGULATES GENE EXPRESSION 28 9.85e-01 -0.002080 9.96e-01
INITIAL TRIGGERING OF COMPLEMENT 11 9.91e-01 0.002030 9.97e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 9.89e-01 -0.001680 9.97e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 9.87e-01 -0.001600 9.97e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 9.90e-01 -0.001550 9.97e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 9.81e-01 -0.001490 9.94e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 9.94e-01 0.001320 9.98e-01
PHASE 2 PLATEAU PHASE 12 9.94e-01 0.001180 9.98e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 32 9.91e-01 0.001170 9.97e-01
GAP JUNCTION DEGRADATION 11 9.95e-01 0.001080 9.98e-01
MAPK FAMILY SIGNALING CASCADES 287 9.75e-01 -0.001080 9.93e-01
HIV TRANSCRIPTION INITIATION 45 9.92e-01 0.000912 9.97e-01
REGULATION OF TP53 ACTIVITY 149 9.90e-01 0.000574 9.97e-01
REGULATION OF BACH1 ACTIVITY 11 9.98e-01 -0.000538 9.98e-01
TRNA PROCESSING 105 9.96e-01 0.000271 9.98e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 9.98e-01 -0.000239 9.98e-01


Detailed Gene set reports



POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
726
set POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize 17
pANOVA 7.45e-06
s.dist 0.628
p.adjustANOVA 0.000572



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tbcb 7012
Tubb2b 6485
Arl2 6353
Tuba4a 5172
Tbcd 5060
Tuba8 4754
Tuba1c 2959
Tbcc 2453
Tbca -1008
Tbce -3125

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tbcb 7012
Tubb2b 6485
Arl2 6353
Tuba4a 5172
Tbcd 5060
Tuba8 4754
Tuba1c 2959
Tbcc 2453
Tbca -1008
Tbce -3125


TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
1138
set TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize 13
pANOVA 0.000228
s.dist 0.59
p.adjustANOVA 0.00596



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Tuba4a 5172
Tuba8 4754
Tuba1c 2959
Gjb2 -4211
Gja1 -4294

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Tuba4a 5172
Tuba8 4754
Tuba1c 2959
Gjb2 -4211
Gja1 -4294


FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
337
set FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize 19
pANOVA 1.23e-05
s.dist 0.579
p.adjustANOVA 0.000725



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Cct5 7963
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Cct7 7270
Tubb3 7249
Cct3 7238
Tubb4a 7218
Tubb2b 6485
Tuba4a 5172
Tuba8 4754
Cct4 3811
Tuba1c 2959
Cct2 622
Cct6a -2053
Cct8 -2181
Tcp1 -3184

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Cct5 7963
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Cct7 7270
Tubb3 7249
Cct3 7238
Tubb4a 7218
Tubb2b 6485
Tuba4a 5172
Tuba8 4754
Cct4 3811
Tuba1c 2959
Cct2 622
Cct6a -2053
Cct8 -2181
Tcp1 -3184


CGMP EFFECTS

CGMP EFFECTS
143
set CGMP EFFECTS
setSize 15
pANOVA 0.000152
s.dist -0.565
p.adjustANOVA 0.00473



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kcnmb2 -8593
Pde1b -8173
Pde10a -8110
Pde1a -7947
Pde2a -7423
Itpr1 -7382
Kcnma1 -7275
Pde5a -6730
Prkg1 -5079
Prkg2 -4790
Pde11a -3892
Kcnmb4 -3824
Irag1 -1232
Pde9a 2599
Kcnmb1 4569

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kcnmb2 -8593
Pde1b -8173
Pde10a -8110
Pde1a -7947
Pde2a -7423
Itpr1 -7382
Kcnma1 -7275
Pde5a -6730
Prkg1 -5079
Prkg2 -4790
Pde11a -3892
Kcnmb4 -3824
Irag1 -1232
Pde9a 2599
Kcnmb1 4569


REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS
785
set REDUCTION OF CYTOSOLIC CA LEVELS
setSize 11
pANOVA 0.00133
s.dist -0.559
p.adjustANOVA 0.0212



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp2b1 -8492
Slc8a1 -8192
Calm1 -7912
Atp2b4 -7751
Atp2a3 -7140
Atp2b2 -6936
Sri -6775
Atp2a2 -4272
Atp2b3 -1357
Slc8a3 1467
Slc8a2 4174

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp2b1 -8492
Slc8a1 -8192
Calm1 -7912
Atp2b4 -7751
Atp2a3 -7140
Atp2b2 -6936
Sri -6775
Atp2a2 -4272
Atp2b3 -1357
Slc8a3 1467
Slc8a2 4174


NITRIC OXIDE STIMULATES GUANYLATE CYCLASE

NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
629
set NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
setSize 20
pANOVA 5.99e-05
s.dist -0.518
p.adjustANOVA 0.00221



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kcnmb2 -8593
Gucy1a1 -8551
Pde1b -8173
Pde10a -8110
Pde1a -7947
Pde2a -7423
Itpr1 -7382
Kcnma1 -7275
Gucy1b1 -6897
Pde5a -6730
Gucy1a2 -5566
Prkg1 -5079
Prkg2 -4790
Pde11a -3892
Kcnmb4 -3824
Irag1 -1232
Nos3 1731
Pde9a 2599
Nos1 2800
Kcnmb1 4569

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kcnmb2 -8593
Gucy1a1 -8551
Pde1b -8173
Pde10a -8110
Pde1a -7947
Pde2a -7423
Itpr1 -7382
Kcnma1 -7275
Gucy1b1 -6897
Pde5a -6730
Gucy1a2 -5566
Prkg1 -5079
Prkg2 -4790
Pde11a -3892
Kcnmb4 -3824
Irag1 -1232
Nos3 1731
Pde9a 2599
Nos1 2800
Kcnmb1 4569


SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
910
set SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
setSize 23
pANOVA 2.23e-05
s.dist 0.511
p.adjustANOVA 0.0011



Top enriched genes

Top 20 genes
GeneID Gene Rank
Lemd2 8336
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Chmp4b 7599
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Chmp7 6852
Tubb2b 6485
Chmp6 6179
Tuba4a 5172
Tuba8 4754
Vps4a 4513
Cc2d1b 4243
Chmp2a 3814
Tuba1c 2959
Chmp3 -111
Ist1 -1820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lemd2 8336
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Chmp4b 7599
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Chmp7 6852
Tubb2b 6485
Chmp6 6179
Tuba4a 5172
Tuba8 4754
Vps4a 4513
Cc2d1b 4243
Chmp2a 3814
Tuba1c 2959
Chmp3 -111
Ist1 -1820
Chmp4c -2091
Spast -3708
Chmp2b -8308


P75NTR REGULATES AXONOGENESIS

P75NTR REGULATES AXONOGENESIS
679
set P75NTR REGULATES AXONOGENESIS
setSize 10
pANOVA 0.00688
s.dist -0.494
p.adjustANOVA 0.0659



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mcf2 -7952
Rtn4 -7632
Omg -7276
Ngfr -6655
Rtn4r -6170
Ngf -4922
Mag -4626
Rhoa -3097
Lingo1 -2615
Arhgdia 8150

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mcf2 -7952
Rtn4 -7632
Omg -7276
Ngfr -6655
Rtn4r -6170
Ngf -4922
Mag -4626
Rhoa -3097
Lingo1 -2615
Arhgdia 8150


APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION
66
set APOPTOSIS INDUCED DNA FRAGMENTATION
setSize 10
pANOVA 0.0091
s.dist -0.476
p.adjustANOVA 0.0801



Top enriched genes

Top 20 genes
GeneID Gene Rank
H1f2 -8585
H1f0 -8564
Hmgb1 -7098
Kpna1 -6304
Hmgb2 -5785
H1f4 -2606
Casp3 -2347
Kpnb1 -1912
Dffb -1325
Dffa 3203

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H1f2 -8585
H1f0 -8564
Hmgb1 -7098
Kpna1 -6304
Hmgb2 -5785
H1f4 -2606
Casp3 -2347
Kpnb1 -1912
Dffb -1325
Dffa 3203


WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
1173
set WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
setSize 13
pANOVA 0.00337
s.dist 0.47
p.adjustANOVA 0.0402



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fzd2 7851
Cltb 7638
Clta 6913
Ap2a1 6686
Ap2s1 6398
Fzd5 6237
Ap2m1 6090
Ap2a2 4317
Ror1 2872
Wnt5a 2566
Ror2 928
Ap2b1 -2190
Cltc -5096

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fzd2 7851
Cltb 7638
Clta 6913
Ap2a1 6686
Ap2s1 6398
Fzd5 6237
Ap2m1 6090
Ap2a2 4317
Ror1 2872
Wnt5a 2566
Ror2 928
Ap2b1 -2190
Cltc -5096


CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION

CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION
161
set CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION
setSize 11
pANOVA 0.0108
s.dist -0.444
p.adjustANOVA 0.0912



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp3r1 -8475
Ahcyl1 -8415
Ppp3ca -8382
Calm1 -7912
Ppp3cb -7899
Nfatc3 -7646
Itpr1 -7382
Nfatc1 247
Itpr2 3158
Itpr3 4749
Nfatc2 5553

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp3r1 -8475
Ahcyl1 -8415
Ppp3ca -8382
Calm1 -7912
Ppp3cb -7899
Nfatc3 -7646
Itpr1 -7382
Nfatc1 247
Itpr2 3158
Itpr3 4749
Nfatc2 5553


GAP JUNCTION ASSEMBLY

GAP JUNCTION ASSEMBLY
368
set GAP JUNCTION ASSEMBLY
setSize 21
pANOVA 0.000568
s.dist 0.434
p.adjustANOVA 0.0112



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Gja4 7674
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Gjb6 5880
Gjd3 5295
Tuba4a 5172
Tuba8 4754
Tuba1c 2959
Gja5 2828
Gjb1 -810
Gjc2 -1109
Gjd2 -3852
Gjc1 -4127
Gjb2 -4211

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Gja4 7674
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Gjb6 5880
Gjd3 5295
Tuba4a 5172
Tuba8 4754
Tuba1c 2959
Gja5 2828
Gjb1 -810
Gjc2 -1109
Gjd2 -3852
Gjc1 -4127
Gjb2 -4211
Gja1 -4294


IRE1ALPHA ACTIVATES CHAPERONES

IRE1ALPHA ACTIVATES CHAPERONES
498
set IRE1ALPHA ACTIVATES CHAPERONES
setSize 50
pANOVA 4.02e-07
s.dist 0.414
p.adjustANOVA 7.94e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Preb 8329
Pdia6 8314
Lmna 8036
Cxxc1 7993
Cul7 7974
Tln1 7828
Dnajb11 7757
Hdgf 7584
Hspa5 7487
Xbp1 7281
Mydgf 7186
Klhdc3 7144
Syvn1 7133
Dctn1 7081
Yif1a 6754
Srpr 6547
Acadvl 6284
Gosr2 6071
Tspyl2 6056
Hyou1 6018

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Preb 8329
Pdia6 8314
Lmna 8036
Cxxc1 7993
Cul7 7974
Tln1 7828
Dnajb11 7757
Hdgf 7584
Hspa5 7487
Xbp1 7281
Mydgf 7186
Klhdc3 7144
Syvn1 7133
Dctn1 7081
Yif1a 6754
Srpr 6547
Acadvl 6284
Gosr2 6071
Tspyl2 6056
Hyou1 6018
Arfgap1 5801
Srprb 5762
Pla2g4b 5672
Tpp1 5630
Gsk3a 5491
Add1 5429
Dnajc3 5337
Ppp2r5b 5276
Sult1a1 4613
Ddx11 4331
Kdelr3 4252
Fkbp14 4231
Pdia5 3992
Zbtb17 3511
Shc1 2907
Atp6v0d1 2713
Extl3 2532
Tatdn2 806
Sec31a -1308
Ern1 -1516
Wipi1 -2072
Ctdsp2 -2708
Gfpt1 -3689
Serp1 -4396
Ssr1 -4536
Extl1 -4804
Wfs1 -4910
Edem1 -5332
Dnajb9 -6985
Extl2 -7902


GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
388
set GLYCOGEN STORAGE DISEASES
setSize 12
pANOVA 0.0142
s.dist 0.409
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gaa 7838
Ubb 7291
G6pc3 6828
Nhlrc1 5452
Uba52 4626
Gys1 4196
Gbe1 4072
Ppp1r3c 3895
Ubc 2638
Rps27a 2557
Gyg -1664
Epm2a -6696

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gaa 7838
Ubb 7291
G6pc3 6828
Nhlrc1 5452
Uba52 4626
Gys1 4196
Gbe1 4072
Ppp1r3c 3895
Ubc 2638
Rps27a 2557
Gyg -1664
Epm2a -6696


VOLTAGE GATED POTASSIUM CHANNELS

VOLTAGE GATED POTASSIUM CHANNELS
1170
set VOLTAGE GATED POTASSIUM CHANNELS
setSize 39
pANOVA 1.43e-05
s.dist -0.402
p.adjustANOVA 0.000801



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kcna2 -8534
Kcnh7 -8521
Kcns1 -8390
Kcnab1 -8331
Kcnq5 -7987
Kcnv1 -7975
Kcnq3 -7831
Kcng1 -7727
Kcnab3 -7681
Kcnc2 -7529
Kcnd3 -7437
Kcnq1 -7284
Kcnd2 -6981
Kcnh3 -6966
Kcna1 -6288
Kcnb2 -5927
Kcnh5 -5308
Kcna4 -5274
Kcnf1 -4994
Kcns2 -4936

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kcna2 -8534
Kcnh7 -8521
Kcns1 -8390
Kcnab1 -8331
Kcnq5 -7987
Kcnv1 -7975
Kcnq3 -7831
Kcng1 -7727
Kcnab3 -7681
Kcnc2 -7529
Kcnd3 -7437
Kcnq1 -7284
Kcnd2 -6981
Kcnh3 -6966
Kcna1 -6288
Kcnb2 -5927
Kcnh5 -5308
Kcna4 -5274
Kcnf1 -4994
Kcns2 -4936
Kcnd1 -4859
Kcna6 -3962
Kcnb1 -3808
Kcnh1 -2683
Kcng4 -2539
Kcnc1 -2105
Kcnq2 -2013
Kcnh4 -1512
Kcna3 -581
Kcnab2 -430
Kcnh8 106
Kcna5 808
Kcnc3 1718
Kcnq4 2725
Kcnh2 3382
Kcng2 3987
Kcnc4 4379
Kcnh6 5744
Kcns3 7485


CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN

CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
112
set CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
setSize 36
pANOVA 4.16e-05
s.dist 0.395
p.adjustANOVA 0.00182



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Ttll10 7533
Tubb6 7443
Ttll8 7378
Tubb3 7249
Tubb4a 7218
Ttll12 6621
Tpgs1 6530
Tubb2b 6485
Ttll11 6316
Ttll9 6159
Tuba4a 5172
Ttll1 4954
Tuba8 4754
Agbl5 4476
Agbl2 4071
Ttll6 3546

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Ttll10 7533
Tubb6 7443
Ttll8 7378
Tubb3 7249
Tubb4a 7218
Ttll12 6621
Tpgs1 6530
Tubb2b 6485
Ttll11 6316
Ttll9 6159
Tuba4a 5172
Ttll1 4954
Tuba8 4754
Agbl5 4476
Agbl2 4071
Ttll6 3546
Svbp 3375
Ttll4 3170
Ttl 3165
Tuba1c 2959
Nicn1 2660
Agbl4 2628
Ttll5 1136
Lrrc49 494
Ttll3 337
Vash1 -200
Ttll13 -1624
Tpgs2 -3177
Agbl3 -3647
Vash2 -4267
Agtpbp1 -7631
Ttll7 -8473


AGGREPHAGY

AGGREPHAGY
43
set AGGREPHAGY
setSize 35
pANOVA 5.81e-05
s.dist 0.393
p.adjustANOVA 0.00221



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsf1 8293
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Vim 7567
Tubb6 7443
Ubb 7291
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Dync1i1 6412
Vcp 6085
Ift88 5601
Hdac6 5424
Tuba4a 5172
Tuba8 4754
Park7 4660
Uba52 4626
Dynll2 4069

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsf1 8293
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Vim 7567
Tubb6 7443
Ubb 7291
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Dync1i1 6412
Vcp 6085
Ift88 5601
Hdac6 5424
Tuba4a 5172
Tuba8 4754
Park7 4660
Uba52 4626
Dynll2 4069
Ube2v1 3672
Tuba1c 2959
Ubc 2638
Rps27a 2557
Dync1h1 2365
Dync1li1 2253
Dynll1 2070
Prkn -1435
Cftr -2284
Pcnt -3562
Arl13b -3569
Dync1i2 -4031
Dync1li2 -4381
Ube2n -7118
Hsp90aa1 -7565


THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT

THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT
1072
set THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT
setSize 66
pANOVA 5.45e-08
s.dist 0.387
p.adjustANOVA 2.14e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Tubb4b 8034
Tubb2a 8027
Psmd3 8001
Tuba1a 7897
Tuba1b 7879
Psmb5 7501
Tubb6 7443
Psme1 7422
Psmd13 7345
Ubb 7291
Tubb3 7249
Tubb4a 7218
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Tubb2b 6485
Psmb6 6408

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Tubb4b 8034
Tubb2a 8027
Psmd3 8001
Tuba1a 7897
Tuba1b 7879
Psmb5 7501
Tubb6 7443
Psme1 7422
Psmd13 7345
Ubb 7291
Tubb3 7249
Tubb4a 7218
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Tubb2b 6485
Psmb6 6408
Plk1 6346
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Tuba4a 5172
Psmb10 4883
Psmc2 4874
Tuba8 4754
Uba52 4626
Psmb7 4582
Psmb1 4506
Psmd2 4249
Psma2 4186
Ccnb2 4120
Psma7 4046
Psmb3 3606
Psmd9 3385
Tuba1c 2959
Ubc 2638
Rps27a 2557
Psma6 2335
Psmd6 2277
Cdkn1a 2186
Hsp90ab1 2018
Psmd5 1752
Psmd1 1242
Trp53 1200
Psmd14 138
Psme3 -87
Psma4 -131
Psma1 -846
Psmf1 -1102
Psma3 -1208
Psmd11 -2344
Psmc1 -2685
Fkbpl -3834
Psmd12 -4537
Psmc6 -5059
Mapre1 -5375
Psme4 -5592
Psmb8 -6856
Psmb9 -7446
Hsp90aa1 -7565


CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
201
set CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
setSize 13
pANOVA 0.0163
s.dist 0.385
p.adjustANOVA 0.116



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ciapin1 8111
Nubp1 7783
Ercc2 6866
Ciao1 6819
Pold1 5251
Brip1 4583
Ciao3 4562
Nubp2 3984
Mms19 3403
Ciao2b 2776
Rtel1 239
Ndor1 -5214
Abcb7 -7377

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ciapin1 8111
Nubp1 7783
Ercc2 6866
Ciao1 6819
Pold1 5251
Brip1 4583
Ciao3 4562
Nubp2 3984
Mms19 3403
Ciao2b 2776
Rtel1 239
Ndor1 -5214
Abcb7 -7377


SODIUM CALCIUM EXCHANGERS

SODIUM CALCIUM EXCHANGERS
1006
set SODIUM CALCIUM EXCHANGERS
setSize 10
pANOVA 0.0353
s.dist -0.384
p.adjustANOVA 0.196



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc24a2 -8535
Slc8a1 -8192
Calm1 -7912
Sri -6775
Slc8b1 -2408
Slc24a3 -2134
Slc24a5 -1806
Slc24a4 -1359
Slc8a3 1467
Slc8a2 4174

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc24a2 -8535
Slc8a1 -8192
Calm1 -7912
Sri -6775
Slc8b1 -2408
Slc24a3 -2134
Slc24a5 -1806
Slc24a4 -1359
Slc8a3 1467
Slc8a2 4174


INTRAFLAGELLAR TRANSPORT

INTRAFLAGELLAR TRANSPORT
487
set INTRAFLAGELLAR TRANSPORT
setSize 51
pANOVA 2.07e-06
s.dist 0.384
p.adjustANOVA 0.000244



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dynlrb2 8377
Ift122 8095
Tubb4b 8034
Tubb2a 8027
Ift22 7913
Tuba1a 7897
Tuba1b 7879
Dync2i2 7841
Ift46 7683
Ift172 7486
Tubb6 7443
Kif17 7328
Tubb3 7249
Tubb4a 7218
Ift74 7213
Ift43 7004
Tubb2b 6485
Dynlt5 5659
Ift88 5601
Ift57 5352

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dynlrb2 8377
Ift122 8095
Tubb4b 8034
Tubb2a 8027
Ift22 7913
Tuba1a 7897
Tuba1b 7879
Dync2i2 7841
Ift46 7683
Ift172 7486
Tubb6 7443
Kif17 7328
Tubb3 7249
Tubb4a 7218
Ift74 7213
Ift43 7004
Tubb2b 6485
Dynlt5 5659
Ift88 5601
Ift57 5352
Tuba4a 5172
Ift140 4868
Dync2i1 4816
Ift52 4497
Ift27 4198
Dynll2 4069
Wdr35 3960
Tuba1c 2959
Dync2li1 2495
Dynll1 2070
Ttc30b 1747
Kif3c 1727
Dync2h1 1545
Dynlrb1 1247
Dynlt2a2 1141
Hspb11 569
Traf3ip1 437
Cluap1 383
Ift20 265
Kif3a 188
Ttc30a1 -328
Kif3b -349
Ift80 -814
Ift81 -1254
Ttc21b -1648
Dynlt2b -1872
Trip11 -2698
Wdr19 -3581
Kifap3 -5578
Tnpo1 -6035
Ttc26 -6595


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
180
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 0.000727
s.dist 0.383
p.adjustANOVA 0.0132



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Cct5 7963
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Cct7 7270
Tubb3 7249
Cct3 7238
Tubb4a 7218
Tubb2b 6485
Tuba4a 5172
Tuba8 4754
Pfdn1 4143
Pfdn6 3892
Cct4 3811
Tuba1c 2959
Pfdn5 1704
Pfdn2 869
Cct2 622

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Cct5 7963
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Cct7 7270
Tubb3 7249
Cct3 7238
Tubb4a 7218
Tubb2b 6485
Tuba4a 5172
Tuba8 4754
Pfdn1 4143
Pfdn6 3892
Cct4 3811
Tuba1c 2959
Pfdn5 1704
Pfdn2 869
Cct2 622
Cct6a -2053
Cct8 -2181
Tcp1 -3184
Pfdn4 -6239
Vbp1 -6477
Actb -7374


CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
187
set CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
setSize 11
pANOVA 0.0281
s.dist -0.382
p.adjustANOVA 0.165



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adcy1 -8407
Prkar2b -7923
Calm1 -7912
Prkx -6770
Adcy8 -6521
Creb1 -4279
Prkacb -3508
Prkar1a -2084
Prkar2a -149
Prkaca 5428
Prkar1b 5498

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy1 -8407
Prkar2b -7923
Calm1 -7912
Prkx -6770
Adcy8 -6521
Creb1 -4279
Prkacb -3508
Prkar1a -2084
Prkar2a -149
Prkaca 5428
Prkar1b 5498


XENOBIOTICS

XENOBIOTICS
1175
set XENOBIOTICS
setSize 10
pANOVA 0.0378
s.dist -0.379
p.adjustANOVA 0.207



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ahr -8085
Ahrr -6672
Cyp2j9 -6030
Cyp3a13 -5416
Cyp2d22 -4560
Cyp2a5 -4549
Arnt2 -3120
Cyp2s1 -2149
Arnt 1264
Cyp2f2 6271

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ahr -8085
Ahrr -6672
Cyp2j9 -6030
Cyp3a13 -5416
Cyp2d22 -4560
Cyp2a5 -4549
Arnt2 -3120
Cyp2s1 -2149
Arnt 1264
Cyp2f2 6271


ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K

ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K
299
set ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K
setSize 11
pANOVA 0.0296
s.dist -0.379
p.adjustANOVA 0.172



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3ca -7766
Lyn -6788
Pik3r1 -6574
Gab1 -6536
Pik3cb -6050
Epor -5010
Pik3r5 -3904
Irs2 -336
Jak2 1449
Pik3cd 1887
Pik3cg 3335

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3ca -7766
Lyn -6788
Pik3r1 -6574
Gab1 -6536
Pik3cb -6050
Epor -5010
Pik3r5 -3904
Irs2 -336
Jak2 1449
Pik3cd 1887
Pik3cg 3335


NEUROTOXICITY OF CLOSTRIDIUM TOXINS

NEUROTOXICITY OF CLOSTRIDIUM TOXINS
620
set NEUROTOXICITY OF CLOSTRIDIUM TOXINS
setSize 10
pANOVA 0.0386
s.dist -0.378
p.adjustANOVA 0.209



Top enriched genes

Top 20 genes
GeneID Gene Rank
Syt1 -8595
Snap25 -8545
Sv2b -8125
Syt2 -7602
Sv2c -3797
Vamp2 -3525
Vamp1 -1068
Stx1b 405
Sv2a 634
Stx1a 7298

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Syt1 -8595
Snap25 -8545
Sv2b -8125
Syt2 -7602
Sv2c -3797
Vamp2 -3525
Vamp1 -1068
Stx1b 405
Sv2a 634
Stx1a 7298


SIGNALING BY FGFR4 IN DISEASE

SIGNALING BY FGFR4 IN DISEASE
957
set SIGNALING BY FGFR4 IN DISEASE
setSize 10
pANOVA 0.0395
s.dist -0.376
p.adjustANOVA 0.212



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3ca -7766
Frs2 -7121
Kras -6899
Pik3r1 -6574
Nras -6568
Gab1 -6536
Sos1 -4005
Grb2 2781
Plcg1 3725
Hras 6195

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3ca -7766
Frs2 -7121
Kras -6899
Pik3r1 -6574
Nras -6568
Gab1 -6536
Sos1 -4005
Grb2 2781
Plcg1 3725
Hras 6195


DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY

DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY
261
set DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY
setSize 23
pANOVA 0.00196
s.dist -0.373
p.adjustANOVA 0.0285



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ube2d1 -8286
Trim33 -7841
Smad3 -7792
Ncor1 -7616
Skil -7605
Nedd4l -7590
Ube2d3 -6916
Usp9x -6020
Smurf2 -5447
Rnf111 -5382
Parp1 -5188
Ski -4982
Tgif1 -4544
Tgif2 -4233
Smad2 -2411
Ppm1a -2189
Smad4 -2152
Hdac1 -599
Rps27a 2557
Ubc 2638

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2d1 -8286
Trim33 -7841
Smad3 -7792
Ncor1 -7616
Skil -7605
Nedd4l -7590
Ube2d3 -6916
Usp9x -6020
Smurf2 -5447
Rnf111 -5382
Parp1 -5188
Ski -4982
Tgif1 -4544
Tgif2 -4233
Smad2 -2411
Ppm1a -2189
Smad4 -2152
Hdac1 -599
Rps27a 2557
Ubc 2638
Uba52 4626
Ncor2 4981
Ubb 7291


MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
539
set MET ACTIVATES RAP1 AND RAC1
setSize 10
pANOVA 0.0422
s.dist -0.371
p.adjustANOVA 0.221



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rap1a -7384
Gab1 -6536
Rap1b -6062
Crkl -5154
Dock7 -4612
Met -4269
Rac1 -3379
Crk -2188
Grb2 2781
Rapgef1 4472

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rap1a -7384
Gab1 -6536
Rap1b -6062
Crkl -5154
Dock7 -4612
Met -4269
Rac1 -3379
Crk -2188
Grb2 2781
Rapgef1 4472


RHO GTPASES ACTIVATE WASPS AND WAVES

RHO GTPASES ACTIVATE WASPS AND WAVES
856
set RHO GTPASES ACTIVATE WASPS AND WAVES
setSize 36
pANOVA 0.000123
s.dist -0.37
p.adjustANOVA 0.00393



Top enriched genes

Top 20 genes
GeneID Gene Rank
Abi2 -8465
Actr2 -8434
Mapk1 -8349
Abi1 -7871
Actr3 -7730
Actb -7374
Wasf1 -7304
Wipf3 -7250
Btk -7040
Cdc42 -6993
Nckap1 -6586
Ptk2 -6375
Nckap1l -5891
Was -5535
Wipf2 -5179
Wasl -5088
Cyfip2 -4766
Brk1 -3524
Rac1 -3379
Wasf2 -3289

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Abi2 -8465
Actr2 -8434
Mapk1 -8349
Abi1 -7871
Actr3 -7730
Actb -7374
Wasf1 -7304
Wipf3 -7250
Btk -7040
Cdc42 -6993
Nckap1 -6586
Ptk2 -6375
Nckap1l -5891
Was -5535
Wipf2 -5179
Wasl -5088
Cyfip2 -4766
Brk1 -3524
Rac1 -3379
Wasf2 -3289
Wipf1 -3284
Baiap2 -3155
Actg1 -2768
Nck1 -2695
Wasf3 -2391
Abl1 -1987
Cyfip1 -1694
Arpc2 -1127
Arpc5 -893
Arpc3 1525
Arpc4 2183
Grb2 2781
Arpc1a 4633
Mapk3 4683
Arpc1b 6550
Nckipsd 8190


DEFECTIVE EXT2 CAUSES EXOSTOSES 2

DEFECTIVE EXT2 CAUSES EXOSTOSES 2
218
set DEFECTIVE EXT2 CAUSES EXOSTOSES 2
setSize 14
pANOVA 0.0204
s.dist 0.358
p.adjustANOVA 0.134



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sdc4 8044
Gpc4 6965
Gpc6 5972
Sdc1 5862
Ext2 4901
Sdc3 4492
Gpc2 4257
Gpc3 3130
Gpc1 2034
Agrn 2011
Gpc5 -16
Ext1 -1270
Hspg2 -1372
Sdc2 -3214

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sdc4 8044
Gpc4 6965
Gpc6 5972
Sdc1 5862
Ext2 4901
Sdc3 4492
Gpc2 4257
Gpc3 3130
Gpc1 2034
Agrn 2011
Gpc5 -16
Ext1 -1270
Hspg2 -1372
Sdc2 -3214


HDR THROUGH MMEJ ALT NHEJ

HDR THROUGH MMEJ ALT NHEJ
410
set HDR THROUGH MMEJ ALT NHEJ
setSize 10
pANOVA 0.0503
s.dist -0.357
p.adjustANOVA 0.235



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rad50 -8476
Rbbp8 -6168
Nbn -5731
Parp1 -5188
Parp2 -4002
Polq -3570
Mre11a -2950
Lig3 -2794
Fen1 414
Xrcc1 7289

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rad50 -8476
Rbbp8 -6168
Nbn -5731
Parp1 -5188
Parp2 -4002
Polq -3570
Mre11a -2950
Lig3 -2794
Fen1 414
Xrcc1 7289


PI3K EVENTS IN ERBB2 SIGNALING

PI3K EVENTS IN ERBB2 SIGNALING
706
set PI3K EVENTS IN ERBB2 SIGNALING
setSize 15
pANOVA 0.0173
s.dist -0.355
p.adjustANOVA 0.118



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nrg1 -8488
Nrg3 -7905
Pik3ca -7766
Erbb4 -7701
Egfr -7101
Pik3r1 -6574
Gab1 -6536
Erbb3 -6352
Egf -5322
Hbegf -556
Btc -192
Grb2 2781
Nrg4 3770
Erbb2 4211
Nrg2 7310

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nrg1 -8488
Nrg3 -7905
Pik3ca -7766
Erbb4 -7701
Egfr -7101
Pik3r1 -6574
Gab1 -6536
Erbb3 -6352
Egf -5322
Hbegf -556
Btc -192
Grb2 2781
Nrg4 3770
Erbb2 4211
Nrg2 7310


CYTOSOLIC TRNA AMINOACYLATION

CYTOSOLIC TRNA AMINOACYLATION
204
set CYTOSOLIC TRNA AMINOACYLATION
setSize 24
pANOVA 0.00302
s.dist 0.35
p.adjustANOVA 0.0379



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mars1 7865
Vars 6803
Cars 6710
Farsa 6315
Yars 6286
Aimp2 6269
Tars 6075
Qars 5876
Wars 5829
Ppa1 5203
Farsb 5156
Eef1e1 5066
Aimp1 4797
Aars 4584
Hars 4531
Kars 2987
Gars 2562
Sars 1058
Rars -12
Nars -1271

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mars1 7865
Vars 6803
Cars 6710
Farsa 6315
Yars 6286
Aimp2 6269
Tars 6075
Qars 5876
Wars 5829
Ppa1 5203
Farsb 5156
Eef1e1 5066
Aimp1 4797
Aars 4584
Hars 4531
Kars 2987
Gars 2562
Sars 1058
Rars -12
Nars -1271
Iars -1523
Dars -6612
Lars -6748
Eprs -7848


COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN
164
set COHESIN LOADING ONTO CHROMATIN
setSize 10
pANOVA 0.0555
s.dist -0.35
p.adjustANOVA 0.251



Top enriched genes

Top 20 genes
GeneID Gene Rank
Stag1 -7027
Rad21 -6527
Stag2 -6043
Smc3 -5230
Wapl -3899
Pds5b -3721
Pds5a -2926
Nipbl -1784
Smc1a 1102
Mau2 5540

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Stag1 -7027
Rad21 -6527
Stag2 -6043
Smc3 -5230
Wapl -3899
Pds5b -3721
Pds5a -2926
Nipbl -1784
Smc1a 1102
Mau2 5540


REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA

REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA
804
set REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA
setSize 13
pANOVA 0.0302
s.dist 0.347
p.adjustANOVA 0.175



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ddx41 7495
Ubb 7291
Irf3 6387
Uba52 4626
Trim56 4109
Dtx4 3978
Tbk1 2841
Ubc 2638
Rps27a 2557
Trex1 1736
Trim32 585
Sting1 -1330
Trim21 -5288

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ddx41 7495
Ubb 7291
Irf3 6387
Uba52 4626
Trim56 4109
Dtx4 3978
Tbk1 2841
Ubc 2638
Rps27a 2557
Trex1 1736
Trim32 585
Sting1 -1330
Trim21 -5288


MATURATION OF NUCLEOPROTEIN

MATURATION OF NUCLEOPROTEIN
531
set MATURATION OF NUCLEOPROTEIN
setSize 10
pANOVA 0.0586
s.dist -0.345
p.adjustANOVA 0.263



Top enriched genes

Top 20 genes
GeneID Gene Rank
Parp14 -8525
Gsk3b -7577
Parp6 -4689
Sumo1 -4062
Parp4 -3933
Parp9 -3071
Parp16 -1439
Ube2i -1106
Parp8 14
Parp10 4239

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Parp14 -8525
Gsk3b -7577
Parp6 -4689
Sumo1 -4062
Parp4 -3933
Parp9 -3071
Parp16 -1439
Ube2i -1106
Parp8 14
Parp10 4239


REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
815
set REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize 15
pANOVA 0.0217
s.dist -0.342
p.adjustANOVA 0.138



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dld -7298
Pdk3 -6979
Pdk4 -6754
Pdha1 -6200
Pdpr -6084
Pdp2 -5237
Pdhx -4882
Dlat -4824
Pdp1 -4714
Pdk1 -1947
Pdk2 -1880
Pdhb -1160
Gstz1 1771
Ppard 4962
Rxra 6407

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dld -7298
Pdk3 -6979
Pdk4 -6754
Pdha1 -6200
Pdpr -6084
Pdp2 -5237
Pdhx -4882
Dlat -4824
Pdp1 -4714
Pdk1 -1947
Pdk2 -1880
Pdhb -1160
Gstz1 1771
Ppard 4962
Rxra 6407


ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
15
set ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
setSize 20
pANOVA 0.00881
s.dist 0.338
p.adjustANOVA 0.0786



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Mapt 5513
Tuba4a 5172
Prkag1 4832
Tuba8 4754
Tuba1c 2959
Prkab1 1684
Prkag2 149
Camkk2 -3989
Prkab2 -4187
Prkaa1 -5555
Prkaa2 -7286
Calm1 -7912

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4b 8034
Tubb2a 8027
Tuba1a 7897
Tuba1b 7879
Tubb6 7443
Tubb3 7249
Tubb4a 7218
Tubb2b 6485
Mapt 5513
Tuba4a 5172
Prkag1 4832
Tuba8 4754
Tuba1c 2959
Prkab1 1684
Prkag2 149
Camkk2 -3989
Prkab2 -4187
Prkaa1 -5555
Prkaa2 -7286
Calm1 -7912


CAMK IV MEDIATED PHOSPHORYLATION OF CREB

CAMK IV MEDIATED PHOSPHORYLATION OF CREB
111
set CAMK IV MEDIATED PHOSPHORYLATION OF CREB
setSize 10
pANOVA 0.0644
s.dist -0.338
p.adjustANOVA 0.279



Top enriched genes

Top 20 genes
GeneID Gene Rank
Calm1 -7912
Camk2a -7606
Camk2d -7201
Camk4 -5897
Creb1 -4279
Camkk2 -3989
Kpna2 -651
Camk2b 1442
Camkk1 1722
Camk2g 4876

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calm1 -7912
Camk2a -7606
Camk2d -7201
Camk4 -5897
Creb1 -4279
Camkk2 -3989
Kpna2 -651
Camk2b 1442
Camkk1 1722
Camk2g 4876


DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS

DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS
236
set DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS
setSize 18
pANOVA 0.0141
s.dist 0.334
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pgm1 8304
Neu1 8207
Galk1 8079
Dpm3 7165
Gale 6210
Dhdds 5100
Mpi 4444
Dolk 3470
Srd5a3 2958
Glb1 2455
Gne 2098
Ctsa 2031
Galt 770
Dpm2 -80
Pmm2 -482
Nus1 -3130
Gfpt1 -3689
Dpm1 -3814

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pgm1 8304
Neu1 8207
Galk1 8079
Dpm3 7165
Gale 6210
Dhdds 5100
Mpi 4444
Dolk 3470
Srd5a3 2958
Glb1 2455
Gne 2098
Ctsa 2031
Galt 770
Dpm2 -80
Pmm2 -482
Nus1 -3130
Gfpt1 -3689
Dpm1 -3814


INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE

INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
452
set INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
setSize 22
pANOVA 0.00693
s.dist 0.333
p.adjustANOVA 0.0659



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sgta 7678
Get3 7456
Stx1a 7298
Get1 7198
Stx5a 6889
Get4 6825
Emd 6126
Bag6 5819
Sec61g 5347
Sec61b 5240
Hmox1 3876
App 2245
Ubl4a 1734
Cyb5a 415
Ube2j2 105
Prnp -110
Otof -339
Caml -880
Aldh3a2 -1617
Vapa -2474

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sgta 7678
Get3 7456
Stx1a 7298
Get1 7198
Stx5a 6889
Get4 6825
Emd 6126
Bag6 5819
Sec61g 5347
Sec61b 5240
Hmox1 3876
App 2245
Ubl4a 1734
Cyb5a 415
Ube2j2 105
Prnp -110
Otof -339
Caml -880
Aldh3a2 -1617
Vapa -2474
Vamp2 -3525
Serp1 -4396


DISEASES OF CARBOHYDRATE METABOLISM

DISEASES OF CARBOHYDRATE METABOLISM
239
set DISEASES OF CARBOHYDRATE METABOLISM
setSize 28
pANOVA 0.00248
s.dist 0.33
p.adjustANOVA 0.0322



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sgsh 8093
Gaa 7838
Taldo1 7523
Ubb 7291
G6pc3 6828
Khk 6701
Nhlrc1 5452
Galns 5079
Uba52 4626
Hyal1 4498
Gys1 4196
Gbe1 4072
Gusb 4020
Ppp1r3c 3895
Rpia 3041
Ubc 2638
Rps27a 2557
Glb1 2455
Gns 2361
Aldob 1986

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sgsh 8093
Gaa 7838
Taldo1 7523
Ubb 7291
G6pc3 6828
Khk 6701
Nhlrc1 5452
Galns 5079
Uba52 4626
Hyal1 4498
Gys1 4196
Gbe1 4072
Gusb 4020
Ppp1r3c 3895
Rpia 3041
Ubc 2638
Rps27a 2557
Glb1 2455
Gns 2361
Aldob 1986
Dcxr 670
Idua 607
Naglu -1234
Hgsnat -1380
Arsb -1426
Gyg -1664
Epm2a -6696
Ids -7067


KERATAN SULFATE DEGRADATION

KERATAN SULFATE DEGRADATION
505
set KERATAN SULFATE DEGRADATION
setSize 12
pANOVA 0.0518
s.dist 0.324
p.adjustANOVA 0.239



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hexa 7239
Prelp 6607
Fmod 6014
Lum 5928
Galns 5079
Glb1l 3632
Omd 2868
Glb1 2455
Gns 2361
Ogn -441
Acan -3734
Hexb -5622

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hexa 7239
Prelp 6607
Fmod 6014
Lum 5928
Galns 5079
Glb1l 3632
Omd 2868
Glb1 2455
Gns 2361
Ogn -441
Acan -3734
Hexb -5622


AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA

AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
85
set AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
setSize 53
pANOVA 4.72e-05
s.dist 0.323
p.adjustANOVA 0.00199



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Psmd3 8001
Hspb1 7813
Psmb5 7501
Psme1 7422
Psmd13 7345
Ubb 7291
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Psmb6 6408
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Eif4g1 5089

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Psmd3 8001
Hspb1 7813
Psmb5 7501
Psme1 7422
Psmd13 7345
Ubb 7291
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Psmb6 6408
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Eif4g1 5089
Psmb10 4883
Psmc2 4874
Uba52 4626
Psmb7 4582
Psmb1 4506
Psmd2 4249
Psma2 4186
Psma7 4046
Hspa8 3751
Psmb3 3606
Psmd9 3385
Ubc 2638
Rps27a 2557
Psma6 2335
Psmd6 2277
Psmd5 1752
Psmd1 1242
Psmd14 138
Psme3 -87
Psma4 -131
Hspa1a -835
Psma1 -846
Psmf1 -1102
Psma3 -1208
Psmd11 -2344
Psmc1 -2685
Psmd12 -4537
Psmc6 -5059
Psme4 -5592
Psmb8 -6856
Pabpc1 -6888
Hnrnpd -7269
Psmb9 -7446


CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
190
set CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize 46
pANOVA 0.00016
s.dist 0.322
p.adjustANOVA 0.00473



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Psmd3 8001
Psmb5 7501
Psme1 7422
Psmd13 7345
Mrc2 7063
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Psmb6 6408
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Psmb10 4883
Psmc2 4874

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Psmd3 8001
Psmb5 7501
Psme1 7422
Psmd13 7345
Mrc2 7063
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Psmb6 6408
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Psmb10 4883
Psmc2 4874
Psmb7 4582
Psmb1 4506
Psmd2 4249
Psma2 4186
Psma7 4046
Psmb3 3606
Psmd9 3385
Psma6 2335
Psmd6 2277
Psmd5 1752
Psmd1 1242
Psmd14 138
Psme3 -87
Psma4 -131
Psma1 -846
Psmf1 -1102
Psma3 -1208
Psmd11 -2344
Psmc1 -2685
Mrc1 -3329
Fcgr1 -4226
Psmd12 -4537
Psmc6 -5059
Psme4 -5592
Psmb8 -6856
Psmb9 -7446


KERATAN SULFATE BIOSYNTHESIS

KERATAN SULFATE BIOSYNTHESIS
504
set KERATAN SULFATE BIOSYNTHESIS
setSize 24
pANOVA 0.0064
s.dist 0.322
p.adjustANOVA 0.0639



Top enriched genes

Top 20 genes
GeneID Gene Rank
B4galt2 8171
St3gal4 8159
B4galt4 7662
B4galt3 7116
St3gal2 6982
Prelp 6607
Chst1 6358
Chst5 6328
Fmod 6014
Lum 5928
St3gal3 3818
B3gnt4 3752
B4gat1 3393
B4galt5 2885
Omd 2868
Chst2 1885
B3gnt7 262
B3gnt2 -422
Ogn -441
St3gal1 -1813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B4galt2 8171
St3gal4 8159
B4galt4 7662
B4galt3 7116
St3gal2 6982
Prelp 6607
Chst1 6358
Chst5 6328
Fmod 6014
Lum 5928
St3gal3 3818
B3gnt4 3752
B4gat1 3393
B4galt5 2885
Omd 2868
Chst2 1885
B3gnt7 262
B3gnt2 -422
Ogn -441
St3gal1 -1813
B4galt6 -3696
Acan -3734
B4galt1 -6116
St3gal6 -7782


SIGNALING BY FGFR3 FUSIONS IN CANCER

SIGNALING BY FGFR3 FUSIONS IN CANCER
955
set SIGNALING BY FGFR3 FUSIONS IN CANCER
setSize 10
pANOVA 0.0793
s.dist -0.32
p.adjustANOVA 0.315



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3ca -7766
Frs2 -7121
Kras -6899
Pik3r1 -6574
Nras -6568
Gab1 -6536
Sos1 -4005
Grb2 2781
Hras 6195
Fgfr3 8471

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3ca -7766
Frs2 -7121
Kras -6899
Pik3r1 -6574
Nras -6568
Gab1 -6536
Sos1 -4005
Grb2 2781
Hras 6195
Fgfr3 8471


REGULATION OF RUNX3 EXPRESSION AND ACTIVITY

REGULATION OF RUNX3 EXPRESSION AND ACTIVITY
819
set REGULATION OF RUNX3 EXPRESSION AND ACTIVITY
setSize 53
pANOVA 5.77e-05
s.dist 0.319
p.adjustANOVA 0.00221



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Psmd3 8001
Psmb5 7501
Psme1 7422
Psmd13 7345
Ubb 7291
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Psmb6 6408
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Psmb10 4883
Psmc2 4874

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmd7 8169
Psmc4 8152
Psmd3 8001
Psmb5 7501
Psme1 7422
Psmd13 7345
Ubb 7291
Psmb4 6979
Sem1 6865
Psmc3 6769
Psmd4 6676
Psmb6 6408
Psmb2 6259
Psmc5 6152
Psmd10 5869
Psma5 5777
Psme2 5538
Psmd8 5385
Psmb10 4883
Psmc2 4874
Uba52 4626
Psmb7 4582
Psmb1 4506
Psmd2 4249
Psma2 4186
Src 4100
Psma7 4046
Psmb3 3606
Psmd9 3385
Tgfb1 2824
Ubc 2638
Rps27a 2557
Psma6 2335
Psmd6 2277
Psmd5 1752
Psmd1 1242
Psmd14 138
Mdm2 120
Psme3 -87
Psma4 -131
Psma1 -846
Psmf1 -1102
Psma3 -1208
Smurf1 -1561
Ep300 -2008
Psmd11 -2344
Psmc1 -2685
Cbfb -3645
Psmd12 -4537
Psmc6 -5059
Smurf2 -5447
Psmb8 -6856
Psmb9 -7446


RA BIOSYNTHESIS PATHWAY

RA BIOSYNTHESIS PATHWAY
766
set RA BIOSYNTHESIS PATHWAY
setSize 12
pANOVA 0.0555
s.dist 0.319
p.adjustANOVA 0.251



Top enriched genes

Top 20 genes
GeneID Gene Rank
Aldh1a1 8243
Crabp1 7111
Rdh5 7035
Dhrs4 6318
Rdh14 2712
Rdh11 2135
Rdh10 1552
Aldh1a3 1356
Rdh13 1084
Dhrs3 973
Aldh1a2 -1666
Cyp26b1 -4966

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aldh1a1 8243
Crabp1 7111
Rdh5 7035
Dhrs4 6318
Rdh14 2712
Rdh11 2135
Rdh10 1552
Aldh1a3 1356
Rdh13 1084
Dhrs3 973
Aldh1a2 -1666
Cyp26b1 -4966


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          caTools_1.18.2         
## [16] utf8_1.2.3              promises_1.2.1          rmarkdown_2.24         
## [19] tzdb_0.4.0              xfun_0.40               zlibbioc_1.46.0        
## [22] cachem_1.0.8            jsonlite_1.8.7          highr_0.10             
## [25] later_1.3.1             DelayedArray_0.26.7     reshape_0.8.9          
## [28] BiocParallel_1.34.2     parallel_4.3.1          R6_2.5.1               
## [31] bslib_0.5.1             stringi_1.7.12          RColorBrewer_1.1-3     
## [34] jquerylib_0.1.4         assertthat_0.2.1        Rcpp_1.0.11            
## [37] knitr_1.43              httpuv_1.6.11           Matrix_1.6-1           
## [40] timechange_0.2.0        tidyselect_1.2.0        rstudioapi_0.15.0      
## [43] abind_1.4-5             yaml_2.3.7              codetools_0.2-19       
## [46] lattice_0.21-8          plyr_1.8.8              shiny_1.7.5            
## [49] withr_2.5.0             evaluate_0.21           polyclip_1.10-4        
## [52] xml2_1.3.5              pillar_1.9.0            KernSmooth_2.23-22     
## [55] generics_0.1.3          RCurl_1.98-1.12         hms_1.1.3              
## [58] munsell_0.5.0           scales_1.2.1            xtable_1.8-4           
## [61] glue_1.6.2              tools_4.3.1             data.table_1.14.8      
## [64] webshot_0.5.5           locfit_1.5-9.8          fastmatch_1.1-4        
## [67] cowplot_1.1.1           grid_4.3.1              colorspace_2.1-0       
## [70] GenomeInfoDbData_1.2.10 cli_3.6.1               fansi_1.0.4            
## [73] viridisLite_0.4.2       S4Arrays_1.0.5          svglite_2.1.1          
## [76] gtable_0.3.4            sass_0.4.7              digest_0.6.33          
## [79] htmlwidgets_1.6.2       htmltools_0.5.6         lifecycle_1.0.3        
## [82] httr_1.4.7              mime_0.12

END of report