date generated: 2024-06-05

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik 0.2684894 1.8312366
0610009E02Rik -0.7521235 -0.1037028
0610009L18Rik -1.1838923 -0.0756377
0610010K14Rik -0.0433030 0.4176706
0610012G03Rik -0.1930476 0.0087096
0610030E20Rik 1.0496464 -1.6095238

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 16550
duplicated_genes_present 0
num_profile_genes_in_sets 8251
num_profile_genes_not_in_sets 8299
profile_pearson_correl 0.09187
profile_spearman_correl 0.06957

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 438
num_genesets_included 1166

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 264

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.47e-25 1.01e-22 0.680 0.44300 0.5160 9.10e-13 9.08e-17
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.50e-04 6.40e-03 0.659 0.07890 0.6540 6.50e-01 1.73e-04
MET ACTIVATES RAP1 AND RAC1 11 1.29e-03 8.80e-03 0.618 -0.56800 0.2450 1.11e-03 1.60e-01
COMPLEX I BIOGENESIS 56 1.24e-13 7.24e-12 0.612 0.29500 0.5360 1.33e-04 3.84e-12
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 1.61e-21 2.09e-19 0.603 0.38000 0.4680 1.91e-10 4.28e-15
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.27e-03 1.42e-02 0.601 0.37200 0.4720 2.56e-02 4.64e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 3.75e-23 6.25e-21 0.589 0.32400 0.4910 8.02e-09 2.32e-18
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 3.06e-05 4.25e-04 0.589 -0.22200 0.5450 9.34e-02 3.92e-05
INITIAL TRIGGERING OF COMPLEMENT 10 8.50e-03 3.95e-02 0.582 0.47400 0.3370 9.40e-03 6.48e-02
CD28 DEPENDENT VAV1 PATHWAY 10 4.56e-03 2.44e-02 0.578 -0.40900 0.4090 2.50e-02 2.53e-02
EUKARYOTIC TRANSLATION INITIATION 114 6.19e-23 9.02e-21 0.565 0.30600 0.4750 1.73e-08 1.93e-18
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.43e-03 1.49e-02 0.557 0.03560 0.5560 8.24e-01 5.21e-04
PINK1 PRKN MEDIATED MITOPHAGY 22 6.10e-05 7.33e-04 0.554 0.18800 0.5210 1.27e-01 2.34e-05
RESPIRATORY ELECTRON TRANSPORT 102 4.04e-20 4.28e-18 0.554 0.21000 0.5120 2.46e-04 3.84e-19
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 5.72e-03 2.82e-02 0.553 0.32000 0.4510 5.52e-02 6.80e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 9.69e-12 4.71e-10 0.551 0.27000 0.4800 3.30e-04 1.73e-10
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 4.63e-03 2.45e-02 0.551 -0.43200 0.3420 1.30e-02 4.97e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 4.74e-24 1.11e-21 0.549 0.21600 0.5050 3.16e-05 1.76e-22
COLLAGEN CHAIN TRIMERIZATION 39 9.42e-09 3.33e-07 0.543 0.42300 -0.3400 4.78e-06 2.38e-04
ASPARTATE AND ASPARAGINE METABOLISM 10 1.20e-02 5.22e-02 0.543 0.01370 0.5420 9.40e-01 2.98e-03
SHC MEDIATED CASCADE FGFR3 12 6.58e-03 3.19e-02 0.541 0.21400 0.4970 1.98e-01 2.89e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.51e-06 3.59e-05 0.540 -0.21600 0.4950 4.41e-02 3.87e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.76e-04 1.73e-03 0.535 -0.00711 0.5350 9.56e-01 3.42e-05
SELENOAMINO ACID METABOLISM 107 2.80e-19 2.72e-17 0.534 0.33200 0.4190 3.06e-09 7.41e-14
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.12e-02 4.96e-02 0.534 -0.18700 0.5000 3.06e-01 6.18e-03
SCAVENGING BY CLASS A RECEPTORS 13 5.52e-03 2.74e-02 0.533 0.44600 0.2910 5.39e-03 6.90e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 8.61e-03 3.97e-02 0.532 -0.53000 0.0487 2.33e-03 7.80e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.83e-02 7.00e-02 0.530 0.23100 0.4770 2.06e-01 8.97e-03
ACTIVATION OF RAC1 13 3.18e-03 1.84e-02 0.530 -0.49600 0.1850 1.94e-03 2.47e-01
TRIGLYCERIDE CATABOLISM 14 2.54e-03 1.54e-02 0.529 -0.05210 0.5260 7.36e-01 6.53e-04
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 2.65e-03 1.58e-02 0.525 0.19800 0.4870 1.85e-01 1.10e-03
PI 3K CASCADE FGFR3 12 8.58e-03 3.97e-02 0.525 0.18800 0.4910 2.60e-01 3.25e-03
SHC MEDIATED CASCADE FGFR4 10 1.76e-02 6.85e-02 0.524 0.08370 0.5170 6.47e-01 4.64e-03
FRS MEDIATED FGFR3 SIGNALING 14 3.87e-03 2.14e-02 0.523 0.15100 0.5010 3.27e-01 1.17e-03
COMPLEMENT CASCADE 22 2.30e-04 2.18e-03 0.521 0.34400 0.3910 5.23e-03 1.48e-03
FRS MEDIATED FGFR4 SIGNALING 12 7.93e-03 3.73e-02 0.520 0.03200 0.5190 8.48e-01 1.87e-03
CRMPS IN SEMA3A SIGNALING 16 1.81e-03 1.17e-02 0.517 -0.07670 -0.5110 5.95e-01 3.97e-04
NONSENSE MEDIATED DECAY NMD 109 3.99e-18 3.32e-16 0.513 0.35300 0.3720 1.99e-10 1.85e-11
PI 3K CASCADE FGFR4 10 2.02e-02 7.52e-02 0.512 0.05190 0.5100 7.76e-01 5.25e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 5.14e-03 2.63e-02 0.510 -0.12500 0.4950 4.35e-01 2.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 5.90e-04 4.68e-03 0.510 -0.22300 0.4590 1.02e-01 7.51e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.17e-03 8.35e-03 0.509 0.15700 0.4850 2.48e-01 3.72e-04
PLATELET SENSITIZATION BY LDL 15 3.40e-03 1.91e-02 0.505 0.05480 0.5020 7.13e-01 7.54e-04
RHOBTB3 ATPASE CYCLE 10 1.86e-02 7.06e-02 0.505 -0.14100 0.4850 4.40e-01 7.94e-03
CITRIC ACID CYCLE TCA CYCLE 22 2.68e-04 2.44e-03 0.504 0.08870 0.4970 4.72e-01 5.54e-05
GLYCOGEN STORAGE DISEASES 12 1.57e-02 6.30e-02 0.491 0.18600 0.4550 2.66e-01 6.35e-03
SEROTONIN RECEPTORS 10 2.07e-02 7.64e-02 0.491 -0.39300 0.2940 3.13e-02 1.07e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.87e-26 7.28e-24 0.489 0.13900 0.4690 1.69e-03 2.58e-26
DARPP 32 EVENTS 23 1.69e-04 1.70e-03 0.488 -0.20100 0.4450 9.53e-02 2.21e-04
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 4.60e-03 2.45e-02 0.486 0.43700 0.2120 2.45e-03 1.42e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.47e-25 1.01e-22 0.68000 0.443000 0.516000 9.10e-13 9.08e-17
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.50e-04 6.40e-03 0.65900 0.078900 0.654000 6.50e-01 1.73e-04
MET ACTIVATES RAP1 AND RAC1 11 1.29e-03 8.80e-03 0.61800 -0.568000 0.245000 1.11e-03 1.60e-01
COMPLEX I BIOGENESIS 56 1.24e-13 7.24e-12 0.61200 0.295000 0.536000 1.33e-04 3.84e-12
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 1.61e-21 2.09e-19 0.60300 0.380000 0.468000 1.91e-10 4.28e-15
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.27e-03 1.42e-02 0.60100 0.372000 0.472000 2.56e-02 4.64e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 3.75e-23 6.25e-21 0.58900 0.324000 0.491000 8.02e-09 2.32e-18
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 3.06e-05 4.25e-04 0.58900 -0.222000 0.545000 9.34e-02 3.92e-05
INITIAL TRIGGERING OF COMPLEMENT 10 8.50e-03 3.95e-02 0.58200 0.474000 0.337000 9.40e-03 6.48e-02
CD28 DEPENDENT VAV1 PATHWAY 10 4.56e-03 2.44e-02 0.57800 -0.409000 0.409000 2.50e-02 2.53e-02
EUKARYOTIC TRANSLATION INITIATION 114 6.19e-23 9.02e-21 0.56500 0.306000 0.475000 1.73e-08 1.93e-18
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.43e-03 1.49e-02 0.55700 0.035600 0.556000 8.24e-01 5.21e-04
PINK1 PRKN MEDIATED MITOPHAGY 22 6.10e-05 7.33e-04 0.55400 0.188000 0.521000 1.27e-01 2.34e-05
RESPIRATORY ELECTRON TRANSPORT 102 4.04e-20 4.28e-18 0.55400 0.210000 0.512000 2.46e-04 3.84e-19
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 5.72e-03 2.82e-02 0.55300 0.320000 0.451000 5.52e-02 6.80e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 9.69e-12 4.71e-10 0.55100 0.270000 0.480000 3.30e-04 1.73e-10
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 4.63e-03 2.45e-02 0.55100 -0.432000 0.342000 1.30e-02 4.97e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 4.74e-24 1.11e-21 0.54900 0.216000 0.505000 3.16e-05 1.76e-22
COLLAGEN CHAIN TRIMERIZATION 39 9.42e-09 3.33e-07 0.54300 0.423000 -0.340000 4.78e-06 2.38e-04
ASPARTATE AND ASPARAGINE METABOLISM 10 1.20e-02 5.22e-02 0.54300 0.013700 0.542000 9.40e-01 2.98e-03
SHC MEDIATED CASCADE FGFR3 12 6.58e-03 3.19e-02 0.54100 0.214000 0.497000 1.98e-01 2.89e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.51e-06 3.59e-05 0.54000 -0.216000 0.495000 4.41e-02 3.87e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.76e-04 1.73e-03 0.53500 -0.007110 0.535000 9.56e-01 3.42e-05
SELENOAMINO ACID METABOLISM 107 2.80e-19 2.72e-17 0.53400 0.332000 0.419000 3.06e-09 7.41e-14
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.12e-02 4.96e-02 0.53400 -0.187000 0.500000 3.06e-01 6.18e-03
SCAVENGING BY CLASS A RECEPTORS 13 5.52e-03 2.74e-02 0.53300 0.446000 0.291000 5.39e-03 6.90e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 8.61e-03 3.97e-02 0.53200 -0.530000 0.048700 2.33e-03 7.80e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.83e-02 7.00e-02 0.53000 0.231000 0.477000 2.06e-01 8.97e-03
ACTIVATION OF RAC1 13 3.18e-03 1.84e-02 0.53000 -0.496000 0.185000 1.94e-03 2.47e-01
TRIGLYCERIDE CATABOLISM 14 2.54e-03 1.54e-02 0.52900 -0.052100 0.526000 7.36e-01 6.53e-04
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 2.65e-03 1.58e-02 0.52500 0.198000 0.487000 1.85e-01 1.10e-03
PI 3K CASCADE FGFR3 12 8.58e-03 3.97e-02 0.52500 0.188000 0.491000 2.60e-01 3.25e-03
SHC MEDIATED CASCADE FGFR4 10 1.76e-02 6.85e-02 0.52400 0.083700 0.517000 6.47e-01 4.64e-03
FRS MEDIATED FGFR3 SIGNALING 14 3.87e-03 2.14e-02 0.52300 0.151000 0.501000 3.27e-01 1.17e-03
COMPLEMENT CASCADE 22 2.30e-04 2.18e-03 0.52100 0.344000 0.391000 5.23e-03 1.48e-03
FRS MEDIATED FGFR4 SIGNALING 12 7.93e-03 3.73e-02 0.52000 0.032000 0.519000 8.48e-01 1.87e-03
CRMPS IN SEMA3A SIGNALING 16 1.81e-03 1.17e-02 0.51700 -0.076700 -0.511000 5.95e-01 3.97e-04
NONSENSE MEDIATED DECAY NMD 109 3.99e-18 3.32e-16 0.51300 0.353000 0.372000 1.99e-10 1.85e-11
PI 3K CASCADE FGFR4 10 2.02e-02 7.52e-02 0.51200 0.051900 0.510000 7.76e-01 5.25e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 5.14e-03 2.63e-02 0.51000 -0.125000 0.495000 4.35e-01 2.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 5.90e-04 4.68e-03 0.51000 -0.223000 0.459000 1.02e-01 7.51e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.17e-03 8.35e-03 0.50900 0.157000 0.485000 2.48e-01 3.72e-04
PLATELET SENSITIZATION BY LDL 15 3.40e-03 1.91e-02 0.50500 0.054800 0.502000 7.13e-01 7.54e-04
RHOBTB3 ATPASE CYCLE 10 1.86e-02 7.06e-02 0.50500 -0.141000 0.485000 4.40e-01 7.94e-03
CITRIC ACID CYCLE TCA CYCLE 22 2.68e-04 2.44e-03 0.50400 0.088700 0.497000 4.72e-01 5.54e-05
GLYCOGEN STORAGE DISEASES 12 1.57e-02 6.30e-02 0.49100 0.186000 0.455000 2.66e-01 6.35e-03
SEROTONIN RECEPTORS 10 2.07e-02 7.64e-02 0.49100 -0.393000 0.294000 3.13e-02 1.07e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.87e-26 7.28e-24 0.48900 0.139000 0.469000 1.69e-03 2.58e-26
DARPP 32 EVENTS 23 1.69e-04 1.70e-03 0.48800 -0.201000 0.445000 9.53e-02 2.21e-04
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 4.60e-03 2.45e-02 0.48600 0.437000 0.212000 2.45e-03 1.42e-01
CROSSLINKING OF COLLAGEN FIBRILS 13 7.67e-03 3.64e-02 0.48400 0.408000 -0.260000 1.09e-02 1.04e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 3.29e-03 1.89e-02 0.48100 -0.081700 0.474000 5.71e-01 1.02e-03
FATTY ACYL COA BIOSYNTHESIS 32 1.79e-05 2.78e-04 0.48000 0.056500 0.477000 5.80e-01 3.01e-06
GLYCOGEN SYNTHESIS 14 8.95e-03 4.09e-02 0.48000 0.101000 0.469000 5.15e-01 2.37e-03
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.49e-02 6.08e-02 0.47500 0.439000 0.182000 6.10e-03 2.56e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 17 3.14e-03 1.82e-02 0.47500 0.008470 0.475000 9.52e-01 6.97e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 1.54e-02 6.19e-02 0.47400 0.197000 0.432000 2.20e-01 7.06e-03
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.68e-02 6.61e-02 0.47300 0.286000 0.377000 7.44e-02 1.86e-02
RAS PROCESSING 23 4.73e-04 3.94e-03 0.47200 0.021000 0.471000 8.61e-01 9.15e-05
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 3.97e-02 1.22e-01 0.47000 0.106000 0.458000 5.63e-01 1.21e-02
JOSEPHIN DOMAIN DUBS 11 3.41e-02 1.10e-01 0.46800 0.301000 0.358000 8.41e-02 3.96e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 7.96e-03 3.73e-02 0.46200 -0.000923 0.462000 9.95e-01 1.93e-03
MITOPHAGY 29 1.59e-04 1.64e-03 0.45800 0.149000 0.433000 1.65e-01 5.50e-05
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.68e-03 1.09e-02 0.45700 -0.047700 0.455000 7.12e-01 4.28e-04
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 4.95e-21 5.77e-19 0.45700 0.267000 0.371000 5.56e-09 5.71e-16
FGFR2 LIGAND BINDING AND ACTIVATION 12 2.98e-02 9.98e-02 0.45700 0.282000 0.359000 9.10e-02 3.12e-02
ENOS ACTIVATION 11 3.04e-02 1.01e-01 0.45400 -0.068800 0.449000 6.93e-01 9.90e-03
PROTEIN METHYLATION 17 5.20e-03 2.63e-02 0.45300 0.003140 0.453000 9.82e-01 1.21e-03
CRISTAE FORMATION 31 1.06e-04 1.14e-03 0.45200 0.133000 0.432000 2.00e-01 3.16e-05
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 2.37e-09 8.93e-08 0.44800 0.375000 -0.244000 3.25e-07 8.87e-04
TRANSLATION 286 3.49e-35 4.07e-32 0.44600 0.232000 0.381000 1.70e-11 1.59e-28
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.34e-02 1.09e-01 0.44400 -0.130000 0.425000 4.56e-01 1.47e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 9.52e-03 4.30e-02 0.44200 -0.190000 0.399000 2.04e-01 7.40e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 19 5.02e-03 2.61e-02 0.44200 0.179000 0.404000 1.77e-01 2.31e-03
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 5.04e-02 1.46e-01 0.44000 -0.310000 -0.312000 7.48e-02 7.30e-02
GLYCOGEN METABOLISM 25 1.06e-03 7.74e-03 0.43900 0.203000 0.389000 7.88e-02 7.49e-04
MITOCHONDRIAL TRANSLATION 93 1.77e-11 7.94e-10 0.43500 0.220000 0.375000 2.46e-04 4.26e-10
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.30e-03 1.89e-02 0.43400 0.433000 -0.025900 8.01e-04 8.41e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 5.20e-02 1.48e-01 0.43300 -0.151000 0.406000 4.08e-01 2.62e-02
CELLULAR RESPONSE TO STARVATION 145 7.72e-17 5.63e-15 0.42800 0.247000 0.349000 2.74e-07 4.23e-13
CTLA4 INHIBITORY SIGNALING 19 4.44e-03 2.39e-02 0.42700 -0.121000 0.410000 3.63e-01 1.99e-03
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 2.61e-02 9.03e-02 0.42700 0.422000 -0.065700 8.43e-03 6.82e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.59e-02 1.13e-01 0.42600 -0.038300 0.425000 8.18e-01 1.09e-02
SIGNAL AMPLIFICATION 30 2.39e-04 2.23e-03 0.42600 -0.052200 0.423000 6.21e-01 6.09e-05
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.29e-02 1.28e-01 0.42400 0.096500 0.413000 5.63e-01 1.33e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 17 1.36e-02 5.78e-02 0.41600 0.097900 0.405000 4.85e-01 3.86e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 3.69e-04 3.16e-03 0.41600 0.066800 0.411000 5.20e-01 7.52e-05
METABOLISM OF AMINO ACIDS AND DERIVATIVES 307 4.36e-33 2.54e-30 0.41600 0.186000 0.372000 2.03e-08 4.16e-29
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 3.32e-03 1.89e-02 0.41400 -0.023200 0.413000 8.51e-01 8.01e-04
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 4.43e-07 1.26e-05 0.41200 0.089200 0.403000 2.36e-01 8.93e-08
BRANCHED CHAIN AMINO ACID CATABOLISM 21 4.67e-03 2.45e-02 0.41200 0.002370 0.412000 9.85e-01 1.08e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.35e-05 2.21e-04 0.41200 0.135000 0.389000 1.14e-01 5.02e-06
ER QUALITY CONTROL COMPARTMENT ERQC 21 4.62e-03 2.45e-02 0.41000 -0.041000 0.408000 7.45e-01 1.23e-03
PROCESSING AND ACTIVATION OF SUMO 10 6.75e-02 1.74e-01 0.40900 -0.291000 0.287000 1.11e-01 1.16e-01
GAP JUNCTION DEGRADATION 11 6.94e-02 1.77e-01 0.40900 0.113000 0.393000 5.17e-01 2.40e-02
GLUCONEOGENESIS 27 1.50e-03 9.96e-03 0.40900 0.133000 0.386000 2.31e-01 5.09e-04
METABOLISM OF POLYAMINES 57 9.48e-07 2.35e-05 0.40800 0.077300 0.400000 3.13e-01 1.72e-07
CALNEXIN CALRETICULIN CYCLE 26 1.61e-03 1.06e-02 0.40600 0.015000 0.406000 8.94e-01 3.38e-04
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 7.91e-02 1.92e-01 0.40200 0.164000 0.367000 3.47e-01 3.51e-02
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 2.50e-02 8.67e-02 0.40100 0.151000 0.372000 2.95e-01 1.01e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 3.01e-03 1.76e-02 0.39900 -0.019700 0.399000 8.67e-01 7.16e-04
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 4.22e-06 8.63e-05 0.39800 -0.062000 0.393000 4.44e-01 1.23e-06
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 6.61e-06 1.20e-04 0.39700 0.153000 0.366000 5.39e-02 4.02e-06
GLUTATHIONE CONJUGATION 29 1.26e-03 8.62e-03 0.39600 0.066300 0.390000 5.37e-01 2.76e-04
PYRUVATE METABOLISM 27 1.23e-03 8.57e-03 0.39500 -0.185000 0.348000 9.54e-02 1.73e-03
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 49 5.98e-06 1.14e-04 0.39400 0.357000 -0.165000 1.51e-05 4.56e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 24 4.35e-03 2.36e-02 0.39300 0.080400 0.385000 4.96e-01 1.09e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 2.72e-04 2.45e-03 0.39300 -0.028900 0.392000 7.67e-01 6.05e-05
PEXOPHAGY 11 9.28e-02 2.14e-01 0.39200 0.315000 0.233000 7.01e-02 1.81e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 2.43e-02 8.55e-02 0.39100 -0.390000 0.024700 6.89e-03 8.64e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 6.12e-06 1.15e-04 0.39000 0.077800 0.382000 3.23e-01 1.20e-06
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 4.04e-02 1.23e-01 0.38900 0.209000 0.329000 1.61e-01 2.76e-02
TRP CHANNELS 19 1.37e-02 5.80e-02 0.38900 -0.021900 -0.388000 8.69e-01 3.40e-03
METHYLATION 11 9.08e-02 2.11e-01 0.38900 0.125000 0.368000 4.73e-01 3.45e-02
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.20e-01 2.57e-01 0.38900 -0.239000 -0.306000 1.90e-01 9.34e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 9.92e-06 1.65e-04 0.38900 0.124000 0.368000 1.18e-01 3.55e-06
GLUTAMATE AND GLUTAMINE METABOLISM 13 6.42e-02 1.69e-01 0.38800 0.299000 0.248000 6.24e-02 1.22e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 2.13e-02 7.77e-02 0.38800 -0.205000 0.329000 1.56e-01 2.25e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.11e-02 7.77e-02 0.38600 0.027100 -0.385000 8.47e-01 5.94e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 2.80e-02 9.62e-02 0.38600 -0.219000 0.317000 1.42e-01 3.34e-02
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 5.30e-02 1.50e-01 0.38500 0.383000 -0.037900 1.69e-02 8.13e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 7.63e-02 1.89e-01 0.38400 -0.162000 0.348000 3.51e-01 4.58e-02
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.64e-02 1.72e-01 0.38300 0.165000 0.345000 3.03e-01 3.11e-02
HEDGEHOG LIGAND BIOGENESIS 61 2.83e-06 6.23e-05 0.38200 0.137000 0.357000 6.47e-02 1.42e-06
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 7.53e-02 1.87e-01 0.38200 0.243000 -0.295000 1.64e-01 8.98e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 4.95e-04 4.07e-03 0.38200 0.027400 0.381000 7.79e-01 9.56e-05
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 5.93e-02 1.61e-01 0.38200 0.028200 0.381000 8.60e-01 1.75e-02
CS DS DEGRADATION 14 5.77e-02 1.58e-01 0.38100 0.272000 0.267000 7.81e-02 8.34e-02
CHAPERONE MEDIATED AUTOPHAGY 20 1.70e-02 6.66e-02 0.38100 0.247000 0.291000 5.63e-02 2.44e-02
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 5.14e-03 2.63e-02 0.38100 -0.144000 0.353000 2.33e-01 3.39e-03
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 8.16e-02 1.96e-01 0.38100 -0.129000 0.358000 4.60e-01 3.97e-02
RHO GTPASES ACTIVATE WASPS AND WAVES 36 2.52e-04 2.31e-03 0.38000 -0.189000 0.330000 5.00e-02 6.20e-04
ANCHORING FIBRIL FORMATION 13 4.93e-02 1.44e-01 0.38000 0.221000 -0.309000 1.67e-01 5.40e-02
INSULIN RECEPTOR RECYCLING 20 1.14e-02 5.00e-02 0.37900 -0.101000 0.365000 4.33e-01 4.72e-03
DEGRADATION OF GLI1 BY THE PROTEASOME 57 7.40e-06 1.27e-04 0.37900 0.107000 0.363000 1.63e-01 2.11e-06
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 6.55e-02 1.71e-01 0.37800 -0.174000 0.335000 2.96e-01 4.44e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 1.33e-01 2.78e-01 0.37700 -0.334000 -0.174000 6.74e-02 3.40e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 11 1.12e-01 2.46e-01 0.37700 0.301000 0.226000 8.34e-02 1.95e-01
PYRIMIDINE SALVAGE 10 1.38e-01 2.83e-01 0.37600 -0.286000 -0.244000 1.17e-01 1.82e-01
INFLUENZA INFECTION 145 4.78e-13 2.65e-11 0.37400 0.216000 0.306000 7.57e-06 2.13e-10
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.44e-02 6.00e-02 0.37300 -0.302000 0.219000 2.29e-02 9.78e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 3.52e-06 7.46e-05 0.37000 0.089700 0.359000 2.18e-01 8.15e-07
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 9.28e-02 2.14e-01 0.36900 0.101000 0.355000 5.45e-01 3.30e-02
SIGNALING BY FGFR4 IN DISEASE 10 1.13e-01 2.48e-01 0.36900 -0.192000 0.315000 2.93e-01 8.44e-02
CYTOSOLIC TRNA AMINOACYLATION 24 1.02e-02 4.57e-02 0.36800 0.303000 0.210000 1.02e-02 7.53e-02
COLLAGEN FORMATION 77 6.42e-08 2.14e-06 0.36800 0.326000 -0.170000 7.46e-07 9.75e-03
PENTOSE PHOSPHATE PATHWAY 13 6.28e-02 1.67e-01 0.36700 -0.144000 0.338000 3.69e-01 3.51e-02
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 1.44e-02 6.00e-02 0.36600 0.343000 0.128000 5.36e-03 2.98e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 1.00e-02 4.49e-02 0.36500 0.004680 0.365000 9.69e-01 2.45e-03
ERYTHROPOIETIN ACTIVATES RAS 13 7.49e-02 1.87e-01 0.36500 0.014100 0.364000 9.30e-01 2.29e-02
STABILIZATION OF P53 54 3.28e-05 4.40e-04 0.36400 0.108000 0.348000 1.70e-01 1.00e-05
ACTIVATION OF SMO 16 3.37e-02 1.09e-01 0.36400 0.305000 -0.198000 3.48e-02 1.70e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.26e-01 2.65e-01 0.36300 0.148000 0.332000 3.94e-01 5.68e-02
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 3.42e-02 1.10e-01 0.36200 -0.333000 -0.141000 1.43e-02 2.99e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 9.89e-02 2.26e-01 0.36200 0.056600 0.357000 7.34e-01 3.21e-02
RHO GTPASES ACTIVATE ROCKS 19 2.96e-02 9.94e-02 0.36200 0.317000 0.174000 1.68e-02 1.89e-01
SMOOTH MUSCLE CONTRACTION 33 2.39e-03 1.48e-02 0.36100 0.291000 0.213000 3.81e-03 3.40e-02
MITOCHONDRIAL PROTEIN IMPORT 63 7.29e-06 1.27e-04 0.36000 0.100000 0.346000 1.68e-01 2.04e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 2.26e-02 8.03e-02 0.35900 0.247000 0.260000 4.98e-02 3.90e-02
TRIGLYCERIDE METABOLISM 22 1.32e-02 5.67e-02 0.35900 -0.038200 0.357000 7.56e-01 3.76e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 7.94e-02 1.92e-01 0.35800 -0.019800 0.358000 9.02e-01 2.55e-02
FERTILIZATION 12 8.87e-02 2.07e-01 0.35700 0.323000 -0.152000 5.30e-02 3.62e-01
DEGRADATION OF AXIN 53 6.06e-05 7.33e-04 0.35600 0.096800 0.342000 2.23e-01 1.63e-05
IRON UPTAKE AND TRANSPORT 51 4.31e-05 5.52e-04 0.35500 -0.105000 0.339000 1.95e-01 2.77e-05
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 4.26e-07 1.24e-05 0.35500 0.009750 0.354000 8.82e-01 6.24e-08
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.08e-01 2.41e-01 0.35400 0.045100 0.351000 7.87e-01 3.53e-02
FRS MEDIATED FGFR2 SIGNALING 18 3.55e-02 1.13e-01 0.35400 0.039000 0.352000 7.74e-01 9.83e-03
RRNA PROCESSING 194 2.57e-15 1.58e-13 0.35300 0.237000 0.262000 1.37e-08 3.22e-10
SIGNALING BY ROBO RECEPTORS 205 3.43e-16 2.35e-14 0.35200 0.178000 0.304000 1.16e-05 6.63e-14
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.02e-03 2.21e-02 0.35000 0.227000 -0.267000 3.78e-02 1.46e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.15e-01 2.50e-01 0.34900 -0.248000 0.246000 1.54e-01 1.58e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.35e-02 1.29e-01 0.34900 0.141000 0.319000 3.00e-01 1.90e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 3.03e-05 4.25e-04 0.34800 0.085900 0.338000 2.54e-01 7.28e-06
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 9.16e-02 2.13e-01 0.34800 0.184000 0.295000 2.33e-01 5.60e-02
AGGREPHAGY 35 1.94e-03 1.24e-02 0.34700 0.345000 0.042100 4.16e-04 6.67e-01
COLLAGEN DEGRADATION 49 8.71e-05 9.96e-04 0.34700 0.315000 -0.146000 1.39e-04 7.63e-02
KILLING MECHANISMS 10 1.53e-01 3.07e-01 0.34600 0.114000 -0.327000 5.34e-01 7.37e-02
CGMP EFFECTS 15 7.93e-02 1.92e-01 0.34600 -0.296000 -0.179000 4.72e-02 2.30e-01
RECEPTOR MEDIATED MITOPHAGY 11 1.42e-01 2.90e-01 0.34500 0.029700 0.344000 8.65e-01 4.82e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 1.97e-02 7.37e-02 0.34500 -0.326000 0.112000 9.62e-03 3.73e-01
PROLONGED ERK ACTIVATION EVENTS 14 6.81e-02 1.75e-01 0.34500 -0.253000 0.234000 1.01e-01 1.29e-01
PROTEIN UBIQUITINATION 69 2.37e-06 5.32e-05 0.34500 -0.133000 0.319000 5.70e-02 4.74e-06
RESPONSE OF MTB TO PHAGOCYTOSIS 21 2.29e-02 8.11e-02 0.34300 -0.036300 0.341000 7.73e-01 6.81e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 1.76e-05 2.77e-04 0.34200 0.144000 0.310000 4.29e-02 1.37e-05
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 8.61e-07 2.18e-05 0.34100 0.056800 0.336000 3.74e-01 1.45e-07
P75NTR SIGNALS VIA NF KB 16 6.73e-02 1.74e-01 0.34100 0.329000 0.089300 2.28e-02 5.36e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.46e-02 1.86e-01 0.34000 0.287000 -0.182000 6.27e-02 2.37e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 7.35e-03 3.53e-02 0.33900 -0.034800 0.337000 7.50e-01 2.01e-03
SEMA4D IN SEMAPHORIN SIGNALING 24 1.65e-02 6.53e-02 0.33900 0.338000 0.025500 4.16e-03 8.29e-01
RHOBTB2 GTPASE CYCLE 23 2.35e-02 8.27e-02 0.33900 0.153000 0.302000 2.03e-01 1.21e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 5.26e-05 6.45e-04 0.33700 0.052200 0.333000 4.88e-01 9.76e-06
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 4.14e-02 1.25e-01 0.33600 -0.097800 0.322000 4.72e-01 1.81e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 1.19e-01 2.56e-01 0.33600 0.324000 0.088900 4.32e-02 5.79e-01
RHO GTPASES ACTIVATE CIT 18 5.83e-02 1.59e-01 0.33600 0.251000 0.223000 6.57e-02 1.01e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 1.63e-01 3.24e-01 0.33600 0.071100 0.328000 6.83e-01 5.96e-02
DERMATAN SULFATE BIOSYNTHESIS 11 1.75e-01 3.44e-01 0.33500 0.193000 0.274000 2.67e-01 1.15e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.11e-02 1.47e-01 0.33500 0.324000 -0.087000 2.09e-02 5.35e-01
ANTIGEN PROCESSING CROSS PRESENTATION 93 2.96e-07 8.86e-06 0.33500 0.093100 0.321000 1.21e-01 8.60e-08
CELLULAR RESPONSE TO HYPOXIA 71 9.89e-06 1.65e-04 0.33400 0.079400 0.325000 2.47e-01 2.26e-06
REGULATION OF PTEN STABILITY AND ACTIVITY 66 2.21e-05 3.30e-04 0.33400 0.068500 0.326000 3.36e-01 4.53e-06
TIGHT JUNCTION INTERACTIONS 18 4.23e-02 1.27e-01 0.33300 -0.305000 0.135000 2.52e-02 3.22e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 3.37e-02 1.09e-01 0.33300 0.078500 0.323000 5.34e-01 1.03e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 3.01e-03 1.76e-02 0.33200 -0.070800 -0.325000 4.62e-01 7.51e-04
MET ACTIVATES PTK2 SIGNALING 29 6.17e-03 3.01e-02 0.33200 0.293000 -0.157000 6.36e-03 1.45e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.16e-02 5.05e-02 0.33200 -0.084700 0.321000 4.55e-01 4.62e-03
SYNDECAN INTERACTIONS 26 1.82e-02 7.00e-02 0.33200 0.250000 0.218000 2.74e-02 5.46e-02
FCERI MEDIATED NF KB ACTIVATION 76 5.10e-06 1.01e-04 0.33100 0.056800 0.326000 3.92e-01 9.11e-07
DEGRADATION OF DVL 55 1.93e-04 1.86e-03 0.33000 0.124000 0.305000 1.11e-01 8.93e-05
PI 3K CASCADE FGFR2 16 7.76e-02 1.90e-01 0.32900 0.052300 0.325000 7.17e-01 2.44e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 1.27e-01 2.68e-01 0.32900 -0.297000 0.141000 7.48e-02 3.97e-01
INTERLEUKIN 37 SIGNALING 19 5.50e-02 1.53e-01 0.32800 0.289000 0.155000 2.92e-02 2.41e-01
INTERACTION BETWEEN L1 AND ANKYRINS 29 8.49e-03 3.95e-02 0.32800 0.036200 -0.326000 7.36e-01 2.37e-03
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 1.63e-01 3.23e-01 0.32700 0.278000 0.174000 9.58e-02 2.98e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 1.34e-01 2.78e-01 0.32700 0.312000 0.097700 5.14e-02 5.42e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.98e-02 7.38e-02 0.32700 0.171000 0.279000 1.31e-01 1.40e-02
REGULATION OF IFNG SIGNALING 13 1.10e-01 2.43e-01 0.32700 -0.290000 0.150000 6.98e-02 3.49e-01
ELASTIC FIBRE FORMATION 36 4.19e-03 2.29e-02 0.32600 0.300000 0.127000 1.82e-03 1.86e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 7.29e-02 1.84e-01 0.32600 -0.315000 -0.083600 2.47e-02 5.51e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 2.96e-02 9.94e-02 0.32500 0.094700 0.311000 4.32e-01 9.79e-03
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 3.34e-02 1.09e-01 0.32500 -0.232000 0.228000 7.28e-02 7.81e-02
INSULIN PROCESSING 24 1.98e-02 7.38e-02 0.32300 -0.309000 0.095700 8.86e-03 4.17e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 4.05e-02 1.23e-01 0.32300 0.063300 0.316000 6.15e-01 1.21e-02
NCAM1 INTERACTIONS 39 1.46e-03 9.82e-03 0.32300 0.210000 -0.245000 2.32e-02 8.12e-03
LDL CLEARANCE 16 8.61e-02 2.03e-01 0.32200 0.047300 0.319000 7.43e-01 2.73e-02
RAB GERANYLGERANYLATION 57 7.43e-05 8.66e-04 0.32200 -0.232000 0.224000 2.47e-03 3.51e-03
PLATELET ADHESION TO EXPOSED COLLAGEN 12 1.70e-01 3.36e-01 0.32200 0.145000 0.288000 3.85e-01 8.45e-02
PHASE II CONJUGATION OF COMPOUNDS 60 9.37e-05 1.05e-03 0.32200 0.010600 0.321000 8.87e-01 1.68e-05
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 1.89e-01 3.63e-01 0.32200 -0.237000 0.217000 1.94e-01 2.34e-01
PKMTS METHYLATE HISTONE LYSINES 48 5.40e-04 4.41e-03 0.32100 0.023700 -0.320000 7.76e-01 1.23e-04
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 1.45e-02 6.00e-02 0.32100 -0.136000 0.290000 2.29e-01 1.05e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 2.95e-02 9.94e-02 0.32000 -0.087100 0.308000 4.79e-01 1.23e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 8.61e-02 2.03e-01 0.32000 -0.277000 0.159000 6.29e-02 2.85e-01
ECM PROTEOGLYCANS 64 3.94e-05 5.11e-04 0.32000 0.310000 -0.077100 1.78e-05 2.86e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.77e-02 6.87e-02 0.31900 0.051600 0.314000 6.42e-01 4.70e-03
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.53e-02 6.17e-02 0.31800 0.048600 0.315000 6.56e-01 3.95e-03
ABC TRANSPORTER DISORDERS 69 4.53e-05 5.69e-04 0.31800 0.109000 0.299000 1.17e-01 1.80e-05
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 2.25e-01 3.98e-01 0.31700 -0.315000 -0.041100 8.48e-02 8.22e-01
TIE2 SIGNALING 17 7.83e-02 1.91e-01 0.31700 0.017800 0.316000 8.99e-01 2.40e-02
G PROTEIN ACTIVATION 22 3.49e-02 1.12e-01 0.31600 -0.026100 0.315000 8.32e-01 1.04e-02
MET RECEPTOR RECYCLING 10 2.05e-01 3.82e-01 0.31600 -0.133000 0.287000 4.67e-01 1.16e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 3.59e-02 1.13e-01 0.31600 0.086200 0.304000 4.74e-01 1.17e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 5.34e-02 1.50e-01 0.31500 -0.070300 0.307000 5.96e-01 2.04e-02
NUCLEOBASE BIOSYNTHESIS 15 1.01e-01 2.29e-01 0.31500 -0.046200 0.312000 7.57e-01 3.65e-02
PROTEIN LOCALIZATION 156 8.74e-11 3.77e-09 0.31500 -0.005280 0.315000 9.10e-01 1.20e-11
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 3.85e-02 1.19e-01 0.31500 0.122000 0.290000 3.11e-01 1.61e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 2.34e-03 1.46e-02 0.31400 0.009250 0.314000 9.18e-01 5.05e-04
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 1.24e-02 5.36e-02 0.31400 0.031800 0.312000 7.63e-01 3.07e-03
INFLAMMASOMES 19 5.72e-02 1.57e-01 0.31400 -0.034000 0.312000 7.98e-01 1.85e-02
SULFUR AMINO ACID METABOLISM 22 4.44e-02 1.31e-01 0.31300 0.103000 0.296000 4.04e-01 1.62e-02
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 2.32e-01 4.07e-01 0.31300 0.031500 0.312000 8.63e-01 8.77e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 7.27e-02 1.84e-01 0.31300 0.163000 0.267000 2.18e-01 4.43e-02
SIGNALING BY BMP 24 2.47e-02 8.63e-02 0.31000 -0.173000 0.258000 1.43e-01 2.89e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 4.91e-02 1.43e-01 0.31000 -0.017900 -0.310000 8.87e-01 1.41e-02
PURINE CATABOLISM 16 1.15e-01 2.50e-01 0.31000 0.171000 0.258000 2.37e-01 7.35e-02
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.19e-02 5.16e-02 0.30900 -0.170000 0.258000 1.14e-01 1.60e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 1.35e-01 2.79e-01 0.30900 0.007270 0.309000 9.62e-01 4.55e-02
FATTY ACID METABOLISM 146 1.22e-09 4.92e-08 0.30900 0.029400 0.307000 5.40e-01 1.51e-10
IRAK4 DEFICIENCY TLR2 4 12 1.83e-01 3.55e-01 0.30900 0.028100 0.307000 8.66e-01 6.53e-02
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 9.78e-05 1.09e-03 0.30800 0.308000 0.013400 1.74e-05 8.52e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 1.41e-01 2.88e-01 0.30800 -0.133000 0.278000 4.06e-01 8.26e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 9.98e-03 4.49e-02 0.30800 0.049400 0.304000 6.24e-01 2.51e-03
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 1.21e-01 2.58e-01 0.30800 -0.276000 0.136000 7.38e-02 3.77e-01
MRNA SPLICING 188 1.21e-11 5.64e-10 0.30800 0.280000 0.128000 3.82e-11 2.58e-03
G PROTEIN BETA GAMMA SIGNALLING 30 1.07e-02 4.76e-02 0.30700 -0.173000 0.254000 1.01e-01 1.61e-02
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 2.33e-01 4.08e-01 0.30600 0.253000 0.173000 1.46e-01 3.22e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 5.10e-07 1.41e-05 0.30600 -0.005420 0.306000 9.24e-01 8.19e-08
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 1.38e-02 5.83e-02 0.30500 0.285000 0.109000 5.25e-03 2.84e-01
GPVI MEDIATED ACTIVATION CASCADE 31 1.44e-02 6.00e-02 0.30500 0.057400 0.300000 5.80e-01 3.86e-03
SIGNALING BY FGFR4 31 1.38e-02 5.83e-02 0.30500 0.032600 0.303000 7.54e-01 3.46e-03
BIOLOGICAL OXIDATIONS 123 8.29e-08 2.68e-06 0.30400 0.097200 0.288000 6.29e-02 3.48e-08
NEGATIVE REGULATION OF FGFR4 SIGNALING 21 5.55e-02 1.54e-01 0.30400 0.021000 0.303000 8.68e-01 1.62e-02
REDUCTION OF CYTOSOLIC CA LEVELS 11 2.25e-01 3.98e-01 0.30300 -0.299000 -0.049700 8.58e-02 7.76e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 6.61e-02 1.72e-01 0.30300 0.165000 0.254000 1.89e-01 4.41e-02
GAP JUNCTION ASSEMBLY 21 6.75e-02 1.74e-01 0.30300 0.233000 0.193000 6.49e-02 1.25e-01
FRS MEDIATED FGFR1 SIGNALING 17 1.01e-01 2.28e-01 0.30200 0.036400 0.300000 7.95e-01 3.23e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 1.13e-01 2.48e-01 0.30200 -0.146000 0.264000 3.28e-01 7.63e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 2.24e-01 3.98e-01 0.30200 0.019900 0.301000 9.09e-01 8.38e-02
RAP1 SIGNALLING 15 1.12e-01 2.46e-01 0.30200 -0.241000 0.181000 1.05e-01 2.25e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 1.92e-01 3.66e-01 0.30100 0.207000 0.218000 1.95e-01 1.73e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.15e-01 3.91e-01 0.30100 0.153000 0.259000 3.60e-01 1.20e-01
RAF ACTIVATION 34 7.96e-03 3.73e-02 0.30000 -0.109000 0.280000 2.73e-01 4.71e-03
ANTIMICROBIAL PEPTIDES 13 1.92e-01 3.66e-01 0.30000 0.175000 0.244000 2.76e-01 1.27e-01
ORC1 REMOVAL FROM CHROMATIN 67 1.16e-04 1.24e-03 0.30000 0.000720 0.300000 9.92e-01 2.15e-05
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 1.76e-02 6.85e-02 0.30000 -0.066800 0.292000 5.33e-01 6.47e-03
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 1.65e-04 1.69e-03 0.30000 -0.019100 0.299000 7.92e-01 3.53e-05
MRNA SPLICING MINOR PATHWAY 52 1.49e-03 9.96e-03 0.29900 0.216000 0.207000 7.11e-03 9.77e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 69 1.25e-04 1.33e-03 0.29900 0.060700 0.292000 3.84e-01 2.67e-05
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 2.79e-01 4.55e-01 0.29800 -0.098700 -0.281000 5.89e-01 1.24e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 1.83e-01 3.55e-01 0.29800 -0.255000 0.154000 1.27e-01 3.55e-01
G1 S DNA DAMAGE CHECKPOINTS 65 2.46e-04 2.28e-03 0.29700 0.085400 0.285000 2.34e-01 7.12e-05
GABA RECEPTOR ACTIVATION 52 6.17e-04 4.83e-03 0.29700 -0.196000 0.224000 1.45e-02 5.27e-03
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 9.98e-04 7.37e-03 0.29700 -0.099400 0.280000 2.24e-01 6.26e-04
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 1.47e-02 6.05e-02 0.29700 0.007450 0.296000 9.42e-01 3.71e-03
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 8.47e-02 2.01e-01 0.29700 0.079800 -0.286000 5.58e-01 3.60e-02
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 2.15e-02 7.82e-02 0.29600 -0.064700 -0.289000 5.40e-01 6.16e-03
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 2.87e-01 4.66e-01 0.29600 -0.268000 -0.126000 1.43e-01 4.89e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 1.48e-04 1.55e-03 0.29600 0.059800 0.290000 3.90e-01 3.17e-05
CLEC7A DECTIN 1 SIGNALING 94 5.42e-06 1.05e-04 0.29600 0.034200 0.294000 5.67e-01 8.69e-07
P75NTR REGULATES AXONOGENESIS 10 2.47e-01 4.21e-01 0.29600 -0.251000 0.156000 1.69e-01 3.93e-01
LYSOSOME VESICLE BIOGENESIS 33 1.46e-02 6.04e-02 0.29500 0.050200 0.291000 6.18e-01 3.83e-03
SARS COV 2 INFECTION 65 1.75e-04 1.73e-03 0.29500 -0.040000 0.292000 5.77e-01 4.64e-05
INTERFERON ALPHA BETA SIGNALING 52 9.57e-04 7.14e-03 0.29500 -0.290000 0.053000 3.01e-04 5.08e-01
DISEASES OF DNA REPAIR 11 2.18e-01 3.93e-01 0.29400 0.254000 -0.149000 1.45e-01 3.92e-01
AQUAPORIN MEDIATED TRANSPORT 40 5.22e-03 2.64e-02 0.29400 -0.018300 0.294000 8.42e-01 1.31e-03
LGI ADAM INTERACTIONS 14 1.44e-01 2.93e-01 0.29300 0.192000 -0.222000 2.14e-01 1.50e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 60 7.20e-04 5.45e-03 0.29300 0.175000 0.235000 1.89e-02 1.64e-03
DISEASES OF CARBOHYDRATE METABOLISM 29 2.90e-02 9.85e-02 0.29300 0.133000 0.262000 2.16e-01 1.48e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 2.30e-05 3.36e-04 0.29300 0.027400 0.292000 6.65e-01 3.84e-06
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 7.66e-03 3.64e-02 0.29300 -0.047500 0.289000 6.17e-01 2.38e-03
CELLULAR RESPONSE TO CHEMICAL STRESS 149 1.27e-08 4.35e-07 0.29300 0.103000 0.274000 2.95e-02 8.35e-09
TNFR2 NON CANONICAL NF KB PATHWAY 79 6.81e-05 8.02e-04 0.29200 0.116000 0.268000 7.57e-02 3.83e-05
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 1.47e-02 6.05e-02 0.29200 -0.064100 0.285000 5.31e-01 5.34e-03
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 8.87e-02 2.07e-01 0.29100 -0.266000 -0.118000 3.92e-02 3.61e-01
C TYPE LECTIN RECEPTORS CLRS 111 8.54e-07 2.18e-05 0.29100 0.018400 0.291000 7.38e-01 1.25e-07
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 5.90e-04 4.68e-03 0.29000 -0.176000 0.231000 2.42e-02 3.04e-03
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 2.05e-01 3.82e-01 0.28900 -0.266000 0.113000 1.11e-01 4.97e-01
REPRESSION OF WNT TARGET GENES 14 1.92e-01 3.66e-01 0.28900 0.240000 0.162000 1.21e-01 2.95e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 2.12e-02 7.77e-02 0.28900 0.189000 0.218000 5.98e-02 3.04e-02
REGULATION OF RAS BY GAPS 66 3.29e-04 2.91e-03 0.28800 0.058600 0.282000 4.11e-01 7.28e-05
CD28 CO STIMULATION 29 2.18e-02 7.92e-02 0.28800 -0.253000 0.137000 1.84e-02 2.01e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 2.86e-02 9.79e-02 0.28800 -0.131000 0.256000 2.41e-01 2.11e-02
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 2.59e-01 4.34e-01 0.28700 0.018000 0.286000 9.18e-01 1.00e-01
PYROPTOSIS 20 7.96e-02 1.92e-01 0.28700 -0.045900 0.283000 7.22e-01 2.84e-02
SHC1 EVENTS IN EGFR SIGNALING 11 2.34e-01 4.08e-01 0.28700 -0.182000 0.222000 2.96e-01 2.03e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 6.23e-02 1.66e-01 0.28700 -0.218000 0.186000 8.33e-02 1.41e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.09e-01 3.85e-01 0.28600 -0.252000 0.136000 1.31e-01 4.15e-01
SIGNALING BY HIPPO 20 7.25e-02 1.83e-01 0.28600 -0.215000 0.188000 9.62e-02 1.45e-01
SIGNALING BY FGFR3 34 1.76e-02 6.85e-02 0.28500 0.060200 0.279000 5.44e-01 4.92e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 1.42e-01 2.90e-01 0.28500 -0.143000 -0.246000 3.07e-01 7.87e-02
PRE NOTCH PROCESSING IN GOLGI 17 1.45e-01 2.94e-01 0.28500 0.220000 0.181000 1.17e-01 1.97e-01
RHO GTPASES ACTIVATE KTN1 11 2.74e-01 4.52e-01 0.28400 0.074200 0.275000 6.70e-01 1.15e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 1.73e-04 1.73e-03 0.28400 -0.161000 0.234000 2.27e-02 9.14e-04
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 3.96e-06 8.24e-05 0.28400 0.084400 0.271000 1.32e-01 1.25e-06
BILE ACID AND BILE SALT METABOLISM 24 6.66e-02 1.72e-01 0.28400 0.187000 0.214000 1.13e-01 7.00e-02
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 2.02e-01 3.79e-01 0.28400 -0.030600 0.282000 8.49e-01 7.82e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 23 5.16e-02 1.48e-01 0.28400 -0.161000 0.233000 1.81e-01 5.28e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 5.47e-02 1.53e-01 0.28300 -0.104000 0.263000 3.89e-01 2.88e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 2.02e-05 3.10e-04 0.28300 0.065400 0.275000 2.76e-01 4.54e-06
SIGNALING BY RETINOIC ACID 32 1.85e-02 7.04e-02 0.28200 -0.084800 0.269000 4.07e-01 8.38e-03
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 11 2.95e-01 4.73e-01 0.28100 0.214000 0.183000 2.20e-01 2.93e-01
HYALURONAN UPTAKE AND DEGRADATION 11 2.64e-01 4.39e-01 0.28100 -0.040300 0.278000 8.17e-01 1.10e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 3.31e-01 5.04e-01 0.28000 -0.142000 -0.241000 4.36e-01 1.87e-01
SHC MEDIATED CASCADE FGFR1 15 1.83e-01 3.55e-01 0.27900 0.071500 0.270000 6.31e-01 7.05e-02
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 2.43e-01 4.17e-01 0.27900 0.207000 0.187000 1.97e-01 2.44e-01
KINESINS 47 3.11e-03 1.81e-02 0.27800 0.121000 -0.251000 1.51e-01 2.95e-03
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 2.20e-02 7.94e-02 0.27600 0.080800 -0.264000 4.29e-01 9.71e-03
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.96e-02 1.92e-01 0.27500 0.265000 0.074600 2.78e-02 5.36e-01
KERATAN SULFATE DEGRADATION 11 3.10e-01 4.82e-01 0.27500 0.210000 0.178000 2.28e-01 3.06e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 5.61e-02 1.55e-01 0.27500 -0.116000 0.249000 3.25e-01 3.44e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 1.16e-03 8.30e-03 0.27500 0.082800 0.262000 2.60e-01 3.57e-04
FC EPSILON RECEPTOR FCERI SIGNALING 123 8.52e-07 2.18e-05 0.27500 -0.013400 0.274000 7.98e-01 1.52e-07
SARS COV 1 INFECTION 48 5.19e-03 2.63e-02 0.27500 0.066600 0.266000 4.25e-01 1.41e-03
PHASE 0 RAPID DEPOLARISATION 31 3.76e-02 1.17e-01 0.27400 -0.161000 -0.222000 1.20e-01 3.24e-02
INTERLEUKIN 1 SIGNALING 95 3.16e-05 4.31e-04 0.27400 0.066600 0.266000 2.62e-01 7.50e-06
FORMATION OF APOPTOSOME 10 2.99e-01 4.75e-01 0.27400 -0.155000 0.226000 3.95e-01 2.16e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 12 2.75e-01 4.52e-01 0.27300 -0.095100 -0.256000 5.69e-01 1.24e-01
BIOTIN TRANSPORT AND METABOLISM 11 3.12e-01 4.83e-01 0.27200 0.249000 0.111000 1.53e-01 5.25e-01
INTERLEUKIN 12 SIGNALING 37 1.58e-02 6.32e-02 0.27200 -0.013300 0.272000 8.89e-01 4.25e-03
N GLYCAN ANTENNAE ELONGATION 15 1.69e-01 3.33e-01 0.27200 -0.156000 0.223000 2.96e-01 1.35e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 1.28e-01 2.69e-01 0.27100 -0.203000 -0.180000 1.17e-01 1.64e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 1.49e-02 6.08e-02 0.27100 0.198000 0.185000 2.83e-02 4.08e-02
SPHINGOLIPID METABOLISM 79 1.67e-04 1.69e-03 0.27000 -0.007280 0.270000 9.11e-01 3.30e-05
PI 3K CASCADE FGFR1 15 2.02e-01 3.79e-01 0.27000 0.050300 0.265000 7.36e-01 7.57e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 7.04e-02 1.79e-01 0.26900 0.056400 0.263000 6.25e-01 2.26e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 2.54e-01 4.28e-01 0.26900 0.070700 0.260000 6.59e-01 1.05e-01
COSTIMULATION BY THE CD28 FAMILY 48 3.79e-03 2.10e-02 0.26900 -0.157000 0.219000 6.01e-02 8.73e-03
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 4.13e-02 1.25e-01 0.26900 -0.089100 0.254000 4.14e-01 2.00e-02
PYRIMIDINE CATABOLISM 10 3.44e-01 5.16e-01 0.26900 -0.266000 -0.038800 1.45e-01 8.32e-01
AMINE LIGAND BINDING RECEPTORS 31 2.87e-02 9.79e-02 0.26800 -0.235000 0.130000 2.38e-02 2.12e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 6.99e-02 1.78e-01 0.26800 -0.178000 0.200000 1.39e-01 9.62e-02
SIGNALING BY CSF3 G CSF 29 3.79e-02 1.17e-01 0.26700 -0.111000 0.243000 3.00e-01 2.37e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.23e-01 2.60e-01 0.26700 -0.196000 -0.181000 1.19e-01 1.52e-01
TRANS GOLGI NETWORK VESICLE BUDDING 70 4.62e-04 3.88e-03 0.26700 -0.053100 0.261000 4.42e-01 1.57e-04
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 5.41e-02 1.52e-01 0.26600 -0.104000 0.245000 3.60e-01 3.03e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 8.65e-02 2.03e-01 0.26600 -0.000971 0.266000 9.94e-01 2.73e-02
THE NLRP3 INFLAMMASOME 15 1.84e-01 3.56e-01 0.26600 -0.149000 0.220000 3.18e-01 1.41e-01
SIGNALING BY INSULIN RECEPTOR 61 1.24e-03 8.57e-03 0.26500 -0.078800 0.253000 2.87e-01 6.31e-04
DNA REPLICATION PRE INITIATION 79 2.12e-04 2.02e-03 0.26500 -0.030100 0.263000 6.44e-01 5.22e-05
CYTOPROTECTION BY HMOX1 119 7.09e-06 1.27e-04 0.26500 0.108000 0.242000 4.27e-02 5.17e-06
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 2.60e-01 4.35e-01 0.26500 -0.146000 0.221000 3.81e-01 1.85e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 3.08e-01 4.81e-01 0.26400 0.217000 0.151000 1.94e-01 3.66e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 80 2.73e-04 2.45e-03 0.26400 0.035000 0.262000 5.88e-01 5.29e-05
INTERLEUKIN 12 FAMILY SIGNALING 44 1.11e-02 4.94e-02 0.26300 0.034600 0.261000 6.91e-01 2.76e-03
HSF1 DEPENDENT TRANSACTIVATION 34 3.03e-02 1.01e-01 0.26300 0.262000 0.023400 8.19e-03 8.13e-01
TCR SIGNALING 101 3.95e-05 5.11e-04 0.26200 0.045300 0.258000 4.31e-01 7.53e-06
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 1.55e-04 1.61e-03 0.26200 0.079900 0.249000 1.93e-01 4.86e-05
PEROXISOMAL LIPID METABOLISM 26 6.50e-02 1.70e-01 0.26200 -0.037800 0.259000 7.39e-01 2.23e-02
NEUTROPHIL DEGRANULATION 383 3.28e-17 2.55e-15 0.26100 0.030400 0.259000 3.09e-01 3.23e-18
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.99e-01 4.75e-01 0.26100 -0.182000 0.187000 2.95e-01 2.83e-01
SIGNALING BY KIT IN DISEASE 20 1.15e-01 2.50e-01 0.26100 -0.230000 0.123000 7.49e-02 3.42e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 7.08e-02 1.79e-01 0.26100 0.005230 0.260000 9.63e-01 2.15e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 6.51e-02 1.70e-01 0.26000 -0.059800 0.253000 5.98e-01 2.54e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 2.22e-02 7.98e-02 0.26000 -0.226000 -0.128000 1.35e-02 1.62e-01
CELL CELL JUNCTION ORGANIZATION 50 5.97e-03 2.92e-02 0.25900 -0.258000 0.024800 1.59e-03 7.62e-01
SIGNALING BY NOTCH4 83 2.91e-04 2.59e-03 0.25900 0.044400 0.255000 4.85e-01 5.98e-05
INWARDLY RECTIFYING K CHANNELS 31 3.89e-02 1.20e-01 0.25800 -0.087100 0.243000 4.01e-01 1.92e-02
INTERLEUKIN 10 SIGNALING 17 1.64e-01 3.26e-01 0.25700 -0.186000 0.177000 1.85e-01 2.06e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 1.21e-01 2.58e-01 0.25700 -0.143000 0.213000 2.67e-01 9.93e-02
DAP12 INTERACTIONS 29 4.83e-02 1.42e-01 0.25700 -0.114000 0.230000 2.87e-01 3.24e-02
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 1.02e-01 2.31e-01 0.25600 -0.102000 0.235000 4.07e-01 5.66e-02
ARACHIDONIC ACID METABOLISM 40 2.23e-02 7.99e-02 0.25500 0.059400 0.248000 5.16e-01 6.56e-03
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 1.11e-01 2.46e-01 0.25500 -0.200000 0.159000 1.14e-01 2.08e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 3.56e-01 5.23e-01 0.25400 0.215000 -0.136000 2.40e-01 4.57e-01
EARLY PHASE OF HIV LIFE CYCLE 14 2.44e-01 4.17e-01 0.25200 -0.109000 0.227000 4.80e-01 1.41e-01
POLO LIKE KINASE MEDIATED EVENTS 13 3.05e-01 4.78e-01 0.25100 0.240000 0.075100 1.35e-01 6.39e-01
RMTS METHYLATE HISTONE ARGININES 42 1.82e-02 7.00e-02 0.25100 0.250000 -0.015700 5.00e-03 8.60e-01
MET ACTIVATES RAS SIGNALING 10 3.67e-01 5.32e-01 0.25000 -0.210000 0.136000 2.50e-01 4.57e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 81 5.55e-04 4.47e-03 0.25000 0.026700 0.249000 6.78e-01 1.09e-04
SIGNALING BY ERBB2 ECD MUTANTS 16 2.09e-01 3.85e-01 0.25000 -0.075900 0.238000 5.99e-01 9.93e-02
METABOLISM OF COFACTORS 18 1.94e-01 3.67e-01 0.24900 0.048600 0.245000 7.21e-01 7.25e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 5.70e-02 1.57e-01 0.24900 -0.222000 0.114000 3.89e-02 2.88e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 1.33e-02 5.70e-02 0.24900 0.223000 0.111000 6.88e-03 1.80e-01
ATTENUATION PHASE 24 1.12e-01 2.46e-01 0.24900 0.246000 0.041600 3.73e-02 7.24e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.11e-01 2.46e-01 0.24900 0.039000 -0.246000 7.46e-01 4.11e-02
INTERLEUKIN 1 FAMILY SIGNALING 123 2.10e-05 3.19e-04 0.24800 0.094800 0.229000 6.95e-02 1.15e-05
GLUCAGON TYPE LIGAND RECEPTORS 23 1.13e-01 2.48e-01 0.24700 -0.055400 0.241000 6.46e-01 4.57e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 2.12e-01 3.87e-01 0.24700 0.123000 0.214000 3.66e-01 1.16e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.63e-09 6.34e-08 0.24600 0.228000 0.090900 1.53e-09 1.61e-02
MAPK6 MAPK4 SIGNALING 83 7.06e-04 5.41e-03 0.24500 0.055500 0.239000 3.82e-01 1.70e-04
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.62e-01 3.23e-01 0.24500 -0.012900 0.245000 9.20e-01 5.83e-02
PEROXISOMAL PROTEIN IMPORT 57 4.73e-03 2.47e-02 0.24400 -0.094500 0.225000 2.17e-01 3.31e-03
PLATELET ACTIVATION SIGNALING AND AGGREGATION 225 3.86e-09 1.41e-07 0.24400 0.044600 0.239000 2.50e-01 6.30e-10
CD28 DEPENDENT PI3K AKT SIGNALING 19 1.90e-01 3.64e-01 0.24400 -0.240000 -0.039600 6.98e-02 7.65e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 4.16e-04 3.52e-03 0.24300 -0.033800 0.241000 5.88e-01 1.13e-04
LATE ENDOSOMAL MICROAUTOPHAGY 31 7.65e-02 1.89e-01 0.24300 0.183000 0.160000 7.81e-02 1.22e-01
COHESIN LOADING ONTO CHROMATIN 10 4.32e-01 5.89e-01 0.24300 0.108000 0.217000 5.53e-01 2.34e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 2.10e-01 3.85e-01 0.24300 -0.062300 0.235000 6.57e-01 9.41e-02
SIGNALING BY FLT3 FUSION PROTEINS 18 2.17e-01 3.93e-01 0.24300 -0.228000 -0.081900 9.34e-02 5.47e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 13 3.42e-01 5.16e-01 0.24300 0.159000 0.183000 3.21e-01 2.53e-01
ERKS ARE INACTIVATED 13 2.96e-01 4.73e-01 0.24200 -0.128000 0.205000 4.25e-01 2.00e-01
DAP12 SIGNALING 24 1.06e-01 2.38e-01 0.24100 -0.136000 0.199000 2.48e-01 9.12e-02
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 9.75e-02 2.23e-01 0.24100 0.028100 0.240000 8.00e-01 3.11e-02
HEDGEHOG ON STATE 82 1.24e-03 8.57e-03 0.24100 0.140000 0.196000 2.82e-02 2.12e-03
EPHRIN SIGNALING 19 1.78e-01 3.48e-01 0.24100 -0.079200 0.227000 5.50e-01 8.64e-02
METABOLISM OF PORPHYRINS 19 1.79e-01 3.50e-01 0.24000 -0.073700 0.229000 5.78e-01 8.41e-02
HEME SIGNALING 44 2.86e-02 9.79e-02 0.24000 -0.149000 -0.188000 8.75e-02 3.07e-02
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 4.07e-01 5.64e-01 0.24000 0.112000 0.212000 5.20e-01 2.23e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 2.41e-01 4.17e-01 0.23900 -0.053300 0.233000 7.12e-01 1.06e-01
S PHASE 153 1.39e-06 3.37e-05 0.23900 -0.060200 0.231000 1.99e-01 8.19e-07
HOST INTERACTIONS OF HIV FACTORS 125 2.49e-05 3.58e-04 0.23800 0.001010 0.238000 9.85e-01 4.33e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 4.09e-01 5.65e-01 0.23800 0.221000 0.087900 2.04e-01 6.14e-01
SIGNALING BY WNT IN CANCER 31 6.03e-02 1.63e-01 0.23800 -0.126000 0.202000 2.23e-01 5.20e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 5.11e-02 1.47e-01 0.23700 -0.197000 0.133000 5.05e-02 1.88e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 7.41e-02 1.86e-01 0.23700 -0.121000 0.204000 2.60e-01 5.74e-02
SELECTIVE AUTOPHAGY 72 3.58e-03 2.00e-02 0.23700 0.175000 0.160000 1.05e-02 1.91e-02
PROCESSING OF INTRONLESS PRE MRNAS 19 1.85e-01 3.57e-01 0.23600 0.202000 -0.122000 1.28e-01 3.59e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.00e-01 3.77e-01 0.23600 0.157000 -0.176000 2.49e-01 1.96e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 2.20e-01 3.96e-01 0.23500 0.191000 -0.138000 1.74e-01 3.24e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 4.25e-01 5.81e-01 0.23500 -0.144000 -0.186000 4.08e-01 2.85e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 2.06e-02 7.63e-02 0.23500 -0.118000 0.204000 1.77e-01 1.94e-02
PLASMA LIPOPROTEIN ASSEMBLY 11 3.77e-01 5.40e-01 0.23400 -0.165000 0.167000 3.44e-01 3.38e-01
FOXO MEDIATED TRANSCRIPTION 59 5.84e-03 2.87e-02 0.23400 -0.112000 0.206000 1.39e-01 6.24e-03
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.87e-01 3.61e-01 0.23400 -0.148000 0.181000 2.64e-01 1.71e-01
METALLOPROTEASE DUBS 25 1.22e-01 2.59e-01 0.23400 -0.041400 0.230000 7.20e-01 4.66e-02
REGULATION OF IFNA SIGNALING 12 3.99e-01 5.58e-01 0.23300 -0.196000 -0.126000 2.40e-01 4.50e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.53e-02 1.54e-01 0.23200 -0.225000 -0.055500 1.78e-02 5.59e-01
REGULATION OF KIT SIGNALING 16 2.87e-01 4.66e-01 0.23200 -0.223000 -0.062300 1.22e-01 6.66e-01
MITOTIC TELOPHASE CYTOKINESIS 13 3.74e-01 5.36e-01 0.23200 0.195000 0.124000 2.23e-01 4.37e-01
VOLTAGE GATED POTASSIUM CHANNELS 40 5.02e-02 1.46e-01 0.23100 -0.140000 -0.183000 1.24e-01 4.49e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.30e-01 5.04e-01 0.23000 -0.168000 0.157000 2.94e-01 3.26e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.93e-02 9.93e-02 0.22900 0.173000 0.150000 3.81e-02 7.17e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 3.64e-01 5.29e-01 0.22800 -0.017400 -0.228000 9.14e-01 1.55e-01
SIGNALING BY NTRK3 TRKC 17 2.42e-01 4.17e-01 0.22800 0.129000 -0.189000 3.58e-01 1.78e-01
GABA B RECEPTOR ACTIVATION 39 4.34e-02 1.29e-01 0.22800 -0.047300 0.223000 6.09e-01 1.59e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 88 1.65e-03 1.08e-02 0.22800 0.128000 0.189000 3.83e-02 2.25e-03
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 6.94e-02 1.77e-01 0.22800 -0.228000 0.009310 2.17e-02 9.25e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.76e-01 3.45e-01 0.22700 -0.170000 -0.151000 1.49e-01 2.01e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 3.59e-04 3.10e-03 0.22700 0.149000 -0.171000 1.16e-02 3.76e-03
INTRAFLAGELLAR TRANSPORT 49 1.90e-02 7.16e-02 0.22700 0.079400 -0.213000 3.36e-01 1.01e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 92 1.11e-03 8.07e-03 0.22600 0.055700 0.219000 3.56e-01 2.88e-04
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 1.04e-01 2.33e-01 0.22500 0.225000 0.016100 3.32e-02 8.79e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 2.18e-03 1.37e-02 0.22500 0.222000 -0.035300 6.42e-04 5.87e-01
SIGNALING BY FGFR2 IIIA TM 19 2.49e-01 4.23e-01 0.22500 0.066900 0.215000 6.13e-01 1.05e-01
SIGNALING BY FGFR1 43 3.81e-02 1.18e-01 0.22500 0.000108 0.225000 9.99e-01 1.08e-02
PARASITE INFECTION 55 1.35e-02 5.75e-02 0.22500 -0.052500 0.219000 5.00e-01 5.06e-03
CD209 DC SIGN SIGNALING 18 2.42e-01 4.17e-01 0.22400 -0.069400 0.213000 6.10e-01 1.18e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 4.63e-01 6.17e-01 0.22400 -0.034500 0.221000 8.50e-01 2.26e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 3.41e-01 5.15e-01 0.22400 -0.209000 -0.080700 1.62e-01 5.89e-01
RHOBTB GTPASE CYCLE 35 8.57e-02 2.03e-01 0.22400 0.129000 0.182000 1.87e-01 6.18e-02
GLYCOSPHINGOLIPID METABOLISM 38 5.56e-02 1.54e-01 0.22300 -0.025100 0.222000 7.89e-01 1.80e-02
DNA DAMAGE BYPASS 46 3.14e-02 1.04e-01 0.22300 -0.223000 0.009390 8.93e-03 9.12e-01
RHO GTPASES ACTIVATE PAKS 21 2.31e-01 4.06e-01 0.22300 0.157000 0.158000 2.12e-01 2.10e-01
EPHB MEDIATED FORWARD SIGNALING 42 3.62e-02 1.14e-01 0.22300 -0.110000 0.194000 2.19e-01 2.97e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 1.33e-01 2.78e-01 0.22200 -0.211000 0.070100 6.27e-02 5.36e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 2.28e-02 8.09e-02 0.22200 -0.003250 -0.222000 9.68e-01 6.05e-03
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 9.56e-02 2.19e-01 0.22200 -0.219000 0.037600 3.52e-02 7.17e-01
IRS MEDIATED SIGNALLING 37 5.82e-02 1.59e-01 0.22200 -0.069200 0.210000 4.67e-01 2.68e-02
INNATE IMMUNE SYSTEM 771 7.24e-24 1.41e-21 0.22000 0.018900 0.219000 3.76e-01 5.61e-25
HDR THROUGH MMEJ ALT NHEJ 10 4.62e-01 6.17e-01 0.21900 0.183000 -0.121000 3.16e-01 5.08e-01
UNWINDING OF DNA 12 4.08e-01 5.65e-01 0.21900 -0.213000 0.052800 2.02e-01 7.51e-01
SIGNALING BY FGFR2 IN DISEASE 36 7.74e-02 1.90e-01 0.21900 0.019000 0.218000 8.43e-01 2.37e-02
REGULATED PROTEOLYSIS OF P75NTR 12 4.38e-01 5.95e-01 0.21900 0.077400 0.205000 6.43e-01 2.20e-01
INTERFERON GAMMA SIGNALING 73 5.34e-03 2.68e-02 0.21800 -0.218000 0.009630 1.31e-03 8.87e-01
LYSINE CATABOLISM 11 4.74e-01 6.29e-01 0.21800 0.201000 0.084600 2.49e-01 6.27e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 3.39e-01 5.13e-01 0.21800 -0.217000 0.017400 1.46e-01 9.07e-01
HDACS DEACETYLATE HISTONES 45 3.26e-02 1.06e-01 0.21800 0.152000 -0.156000 7.86e-02 7.02e-02
HEME BIOSYNTHESIS 13 3.74e-01 5.36e-01 0.21700 -0.126000 0.177000 4.31e-01 2.70e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 1.20e-01 2.57e-01 0.21700 -0.164000 0.142000 1.33e-01 1.93e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 3.23e-01 4.96e-01 0.21700 0.184000 -0.115000 2.18e-01 4.40e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 3.90e-05 5.11e-04 0.21700 -0.050200 0.211000 3.05e-01 1.67e-05
FCERI MEDIATED MAPK ACTIVATION 28 1.33e-01 2.78e-01 0.21700 -0.028400 0.215000 7.95e-01 4.90e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 2.60e-01 4.35e-01 0.21700 0.188000 -0.108000 1.67e-01 4.29e-01
PCP CE PATHWAY 90 2.42e-03 1.49e-02 0.21700 0.081600 0.201000 1.81e-01 1.01e-03
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 10 5.15e-01 6.62e-01 0.21700 -0.111000 -0.186000 5.44e-01 3.08e-01
LONG TERM POTENTIATION 23 2.22e-01 3.97e-01 0.21600 -0.165000 -0.140000 1.72e-01 2.45e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 2.05e-01 3.82e-01 0.21600 0.097400 0.192000 4.09e-01 1.03e-01
OPIOID SIGNALLING 86 1.94e-03 1.24e-02 0.21500 -0.073300 0.202000 2.40e-01 1.18e-03
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.46e-01 6.03e-01 0.21500 0.052800 0.209000 7.51e-01 2.11e-01
PROCESSING OF SMDT1 16 3.07e-01 4.80e-01 0.21400 -0.173000 0.127000 2.32e-01 3.78e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 3.00e-01 4.75e-01 0.21400 -0.211000 0.039500 1.33e-01 7.78e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 59 2.19e-02 7.94e-02 0.21400 -0.190000 -0.098400 1.17e-02 1.91e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 4.35e-01 5.92e-01 0.21400 -0.014000 0.213000 9.33e-01 2.01e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 3.78e-02 1.17e-01 0.21300 -0.172000 0.126000 4.65e-02 1.43e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 7.44e-02 1.86e-01 0.21200 -0.012000 0.212000 8.99e-01 2.37e-02
INTERLEUKIN 27 SIGNALING 10 5.31e-01 6.69e-01 0.21200 0.175000 0.119000 3.38e-01 5.14e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 5.13e-03 2.63e-02 0.21100 0.060300 0.202000 3.45e-01 1.55e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 12 4.51e-01 6.07e-01 0.21100 0.210000 0.015500 2.07e-01 9.26e-01
ADHERENS JUNCTIONS INTERACTIONS 30 1.36e-01 2.82e-01 0.21100 -0.210000 -0.007240 4.61e-02 9.45e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 34 1.21e-01 2.58e-01 0.21100 0.162000 0.135000 1.02e-01 1.74e-01
PLASMA LIPOPROTEIN CLEARANCE 26 1.89e-01 3.63e-01 0.21000 0.057500 0.202000 6.12e-01 7.41e-02
INTEGRIN SIGNALING 24 2.23e-01 3.98e-01 0.21000 0.105000 0.182000 3.74e-01 1.23e-01
PERK REGULATES GENE EXPRESSION 28 1.55e-01 3.11e-01 0.21000 -0.012800 0.209000 9.07e-01 5.55e-02
DISEASES OF IMMUNE SYSTEM 23 2.44e-01 4.18e-01 0.20900 0.149000 0.147000 2.15e-01 2.24e-01
REGULATION OF BACH1 ACTIVITY 11 4.78e-01 6.32e-01 0.20800 -0.042600 0.204000 8.07e-01 2.42e-01
SIGNALING BY ERYTHROPOIETIN 24 2.23e-01 3.98e-01 0.20800 0.063800 0.198000 5.89e-01 9.29e-02
SIALIC ACID METABOLISM 32 1.07e-01 2.40e-01 0.20800 -0.151000 0.144000 1.40e-01 1.60e-01
RESOLUTION OF D LOOP STRUCTURES 30 1.60e-01 3.20e-01 0.20800 -0.103000 -0.181000 3.31e-01 8.68e-02
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 3.29e-01 5.03e-01 0.20800 -0.144000 0.150000 3.18e-01 3.00e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 3.05e-01 4.78e-01 0.20700 0.053700 0.200000 6.85e-01 1.31e-01
TRNA AMINOACYLATION 42 7.36e-02 1.85e-01 0.20700 0.201000 0.049800 2.45e-02 5.76e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 2.09e-01 3.85e-01 0.20600 0.100000 0.180000 3.76e-01 1.12e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 1.37e-01 2.82e-01 0.20600 0.039600 0.202000 6.98e-01 4.79e-02
COPII MEDIATED VESICLE TRANSPORT 66 1.14e-02 5.00e-02 0.20600 -0.170000 0.116000 1.68e-02 1.04e-01
DNA REPLICATION 121 3.88e-04 3.30e-03 0.20500 -0.041800 0.201000 4.28e-01 1.34e-04
CELLULAR HEXOSE TRANSPORT 11 5.20e-01 6.63e-01 0.20500 -0.171000 -0.113000 3.25e-01 5.17e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 3.70e-01 5.35e-01 0.20500 -0.076100 0.190000 6.10e-01 2.02e-01
SIGNALING BY EGFR IN CANCER 22 2.51e-01 4.24e-01 0.20500 0.007460 0.205000 9.52e-01 9.66e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.91e-01 5.51e-01 0.20500 0.115000 -0.169000 4.56e-01 2.73e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 3.99e-01 5.57e-01 0.20500 -0.040800 -0.200000 7.84e-01 1.79e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 3.73e-01 5.36e-01 0.20400 -0.191000 0.073500 2.01e-01 6.22e-01
HSF1 ACTIVATION 26 2.18e-01 3.93e-01 0.20400 0.114000 0.169000 3.12e-01 1.36e-01
INTERLEUKIN 7 SIGNALING 20 3.08e-01 4.80e-01 0.20400 -0.099100 -0.178000 4.43e-01 1.68e-01
REGULATION OF SIGNALING BY CBL 22 2.63e-01 4.39e-01 0.20400 0.042700 0.199000 7.29e-01 1.06e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.92e-01 5.52e-01 0.20400 -0.142000 0.146000 3.58e-01 3.44e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.57e-01 5.23e-01 0.20400 0.043400 0.199000 7.57e-01 1.56e-01
UCH PROTEINASES 88 5.42e-03 2.71e-02 0.20400 0.071800 0.190000 2.44e-01 2.02e-03
MATURATION OF NUCLEOPROTEIN 10 5.59e-01 6.93e-01 0.20400 -0.159000 -0.127000 3.85e-01 4.85e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 2.04e-01 3.82e-01 0.20300 0.026000 0.202000 8.19e-01 7.53e-02
RHOH GTPASE CYCLE 37 9.55e-02 2.19e-01 0.20300 -0.035500 0.200000 7.09e-01 3.54e-02
REGULATED NECROSIS 45 6.18e-02 1.66e-01 0.20200 -0.013000 0.202000 8.80e-01 1.94e-02
PLATELET CALCIUM HOMEOSTASIS 25 2.39e-01 4.14e-01 0.20100 -0.171000 -0.105000 1.38e-01 3.62e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 2.10e-01 3.85e-01 0.20100 -0.148000 0.136000 2.10e-01 2.48e-01
INFECTIOUS DISEASE 727 2.01e-18 1.80e-16 0.20000 0.048000 0.194000 2.84e-02 6.20e-19
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 3.60e-02 1.13e-01 0.20000 0.107000 0.169000 1.53e-01 2.50e-02
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 5.18e-01 6.63e-01 0.20000 0.012200 0.200000 9.44e-01 2.52e-01
METAL ION SLC TRANSPORTERS 24 2.15e-01 3.91e-01 0.20000 -0.120000 0.160000 3.09e-01 1.76e-01
KERATAN SULFATE BIOSYNTHESIS 24 2.36e-01 4.10e-01 0.19900 -0.008440 0.199000 9.43e-01 9.11e-02
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 2.93e-03 1.73e-02 0.19900 -0.090100 0.177000 1.33e-01 3.11e-03
ACYL CHAIN REMODELLING OF PE 16 3.61e-01 5.25e-01 0.19900 -0.127000 0.153000 3.80e-01 2.89e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 3.45e-01 5.16e-01 0.19900 -0.083700 0.180000 5.50e-01 1.99e-01
PURINE SALVAGE 12 4.91e-01 6.46e-01 0.19900 0.003770 0.199000 9.82e-01 2.34e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 5.33e-01 6.70e-01 0.19800 -0.191000 -0.054500 2.73e-01 7.54e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 8.69e-03 3.99e-02 0.19800 0.063600 0.188000 3.14e-01 2.93e-03
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 2.73e-01 4.51e-01 0.19800 0.185000 0.070800 1.24e-01 5.57e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 110 1.39e-03 9.43e-03 0.19800 -0.023300 0.197000 6.73e-01 3.65e-04
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.16e-01 2.52e-01 0.19800 0.164000 0.111000 7.59e-02 2.31e-01
GP1B IX V ACTIVATION SIGNALLING 11 5.04e-01 6.56e-01 0.19800 0.092500 -0.175000 5.95e-01 3.16e-01
METABOLISM OF RNA 643 1.63e-15 1.06e-13 0.19800 0.161000 0.114000 3.50e-12 9.25e-07
SPRY REGULATION OF FGF SIGNALING 16 3.84e-01 5.46e-01 0.19800 -0.025700 0.196000 8.59e-01 1.75e-01
RHO GTPASES ACTIVATE PKNS 47 6.35e-02 1.68e-01 0.19800 -0.000135 0.198000 9.99e-01 1.92e-02
G ALPHA I SIGNALLING EVENTS 193 7.28e-06 1.27e-04 0.19700 -0.097300 0.171000 2.00e-02 4.16e-05
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 3.48e-01 5.18e-01 0.19700 0.127000 -0.150000 3.64e-01 2.85e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 7.54e-02 1.87e-01 0.19700 0.051300 -0.190000 5.61e-01 3.14e-02
NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 4.30e-02 1.28e-01 0.19600 0.196000 0.019500 1.22e-02 8.02e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 2.98e-01 4.74e-01 0.19600 0.185000 -0.065700 1.52e-01 6.11e-01
LAGGING STRAND SYNTHESIS 20 3.31e-01 5.04e-01 0.19600 0.066100 0.185000 6.09e-01 1.53e-01
MUCOPOLYSACCHARIDOSES 11 5.12e-01 6.61e-01 0.19600 -0.080100 0.179000 6.45e-01 3.05e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 42 8.47e-02 2.01e-01 0.19600 -0.026900 0.194000 7.63e-01 2.96e-02
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 5.48e-03 2.73e-02 0.19600 0.119000 -0.155000 5.76e-02 1.35e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX 105 1.64e-03 1.07e-02 0.19500 0.146000 -0.129000 9.67e-03 2.20e-02
PROLACTIN RECEPTOR SIGNALING 11 5.26e-01 6.66e-01 0.19500 -0.024500 0.194000 8.88e-01 2.66e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 6.35e-02 1.68e-01 0.19500 0.192000 -0.035000 2.28e-02 6.78e-01
SYNTHESIS OF PC 25 2.58e-01 4.33e-01 0.19500 0.082400 0.177000 4.76e-01 1.26e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 3.44e-01 5.16e-01 0.19400 0.173000 0.087300 1.80e-01 4.99e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 8.27e-02 1.98e-01 0.19400 -0.076600 0.178000 3.91e-01 4.59e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 5.21e-02 1.48e-01 0.19400 0.072800 -0.179000 3.73e-01 2.82e-02
NRAGE SIGNALS DEATH THROUGH JNK 56 3.51e-02 1.12e-01 0.19300 0.119000 -0.152000 1.23e-01 4.94e-02
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 7.73e-02 1.90e-01 0.19300 0.106000 0.161000 2.01e-01 5.10e-02
PEPTIDE HORMONE METABOLISM 58 3.20e-02 1.05e-01 0.19300 -0.109000 0.159000 1.50e-01 3.67e-02
TRANSLESION SYNTHESIS BY POLH 19 3.54e-01 5.22e-01 0.19300 0.027700 0.191000 8.34e-01 1.51e-01
HEDGEHOG OFF STATE 106 4.27e-03 2.33e-02 0.19200 0.140000 0.131000 1.27e-02 1.95e-02
SARS COV INFECTIONS 139 5.54e-04 4.47e-03 0.19200 0.032000 0.189000 5.16e-01 1.16e-04
GENERATION OF SECOND MESSENGER MOLECULES 20 3.45e-01 5.16e-01 0.19200 0.059200 0.183000 6.46e-01 1.57e-01
TELOMERE EXTENSION BY TELOMERASE 23 2.60e-01 4.35e-01 0.19200 0.085800 -0.172000 4.77e-01 1.54e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.93e-01 4.72e-01 0.19100 0.138000 0.133000 2.43e-01 2.61e-01
PHASE 2 PLATEAU PHASE 13 4.99e-01 6.52e-01 0.19100 -0.042200 -0.186000 7.92e-01 2.44e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.45e-01 5.16e-01 0.19100 -0.189000 0.029000 1.54e-01 8.27e-01
O LINKED GLYCOSYLATION OF MUCINS 40 1.08e-01 2.41e-01 0.19100 -0.189000 0.023100 3.84e-02 8.01e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 2.25e-01 3.98e-01 0.19000 -0.079700 0.173000 4.82e-01 1.27e-01
INTERFERON SIGNALING 160 1.84e-04 1.78e-03 0.19000 -0.190000 -0.001940 3.46e-05 9.66e-01
IRAK1 RECRUITS IKK COMPLEX 14 4.93e-01 6.46e-01 0.19000 0.128000 0.140000 4.08e-01 3.64e-01
AUTOPHAGY 138 9.61e-04 7.14e-03 0.18900 0.099500 0.161000 4.38e-02 1.08e-03
SIGNALING BY FGFR2 64 4.12e-02 1.25e-01 0.18900 0.124000 0.142000 8.60e-02 4.92e-02
NGF STIMULATED TRANSCRIPTION 37 1.20e-01 2.58e-01 0.18900 -0.127000 0.139000 1.80e-01 1.43e-01
SEPARATION OF SISTER CHROMATIDS 164 2.37e-04 2.23e-03 0.18900 0.059200 0.179000 1.92e-01 7.73e-05
REGULATION OF FZD BY UBIQUITINATION 19 3.44e-01 5.16e-01 0.18900 -0.070900 0.175000 5.93e-01 1.87e-01
SODIUM CALCIUM EXCHANGERS 10 5.70e-01 7.02e-01 0.18800 -0.170000 0.080100 3.51e-01 6.61e-01
FGFR2 ALTERNATIVE SPLICING 26 2.37e-01 4.11e-01 0.18800 0.180000 -0.055700 1.12e-01 6.23e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.53e-02 6.18e-02 0.18800 0.121000 0.143000 5.32e-02 2.27e-02
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 2.97e-01 4.74e-01 0.18800 0.063700 0.176000 5.89e-01 1.35e-01
POLYMERASE SWITCHING 14 4.98e-01 6.51e-01 0.18800 0.091000 0.164000 5.55e-01 2.88e-01
SIGNALING BY ACTIVIN 12 5.20e-01 6.63e-01 0.18700 -0.183000 0.041300 2.73e-01 8.04e-01
AURKA ACTIVATION BY TPX2 71 1.90e-02 7.16e-02 0.18700 0.093500 -0.162000 1.73e-01 1.81e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 5.79e-01 7.07e-01 0.18700 -0.179000 0.052700 3.26e-01 7.73e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 5.72e-01 7.02e-01 0.18700 -0.159000 0.098400 3.84e-01 5.90e-01
NEDDYLATION 216 6.39e-06 1.18e-04 0.18700 -0.106000 0.154000 7.29e-03 9.95e-05
NCAM SIGNALING FOR NEURITE OUT GROWTH 59 3.78e-02 1.17e-01 0.18700 0.094000 -0.161000 2.12e-01 3.22e-02
ENDOGENOUS STEROLS 21 3.50e-01 5.20e-01 0.18700 0.174000 0.068000 1.68e-01 5.90e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 5.05e-03 2.62e-02 0.18600 -0.093500 0.161000 1.14e-01 6.44e-03
CELLULAR RESPONSES TO EXTERNAL STIMULI 596 6.74e-13 3.57e-11 0.18600 0.097000 0.158000 5.64e-05 4.91e-11
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 2.30e-01 4.04e-01 0.18600 -0.075100 0.170000 4.99e-01 1.27e-01
PROGRAMMED CELL DEATH 184 8.14e-05 9.40e-04 0.18600 0.003610 0.185000 9.33e-01 1.46e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 3.54e-01 5.22e-01 0.18500 -0.164000 0.087000 2.17e-01 5.12e-01
MITOTIC METAPHASE AND ANAPHASE 204 4.54e-05 5.69e-04 0.18500 0.051800 0.178000 2.03e-01 1.27e-05
RHOQ GTPASE CYCLE 58 6.04e-02 1.63e-01 0.18400 0.066500 0.171000 3.81e-01 2.40e-02
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.52e-02 6.17e-02 0.18300 0.099300 -0.154000 1.30e-01 1.87e-02
KERATAN SULFATE KERATIN METABOLISM 30 2.24e-01 3.98e-01 0.18300 0.010100 0.182000 9.24e-01 8.38e-02
PLATELET AGGREGATION PLUG FORMATION 33 2.12e-01 3.88e-01 0.18300 0.101000 0.152000 3.15e-01 1.31e-01
APOPTOSIS 162 3.41e-04 2.99e-03 0.18200 0.008900 0.182000 8.45e-01 6.48e-05
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 3.19e-01 4.91e-01 0.18200 -0.182000 -0.005270 1.31e-01 9.65e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 2.26e-02 8.03e-02 0.18200 -0.096200 0.154000 1.58e-01 2.38e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 5.32e-01 6.69e-01 0.18100 0.103000 -0.149000 5.37e-01 3.72e-01
HDMS DEMETHYLATE HISTONES 27 2.83e-01 4.62e-01 0.18100 -0.070100 -0.167000 5.28e-01 1.34e-01
G ALPHA Z SIGNALLING EVENTS 45 1.03e-01 2.33e-01 0.18100 -0.037500 0.177000 6.63e-01 4.03e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 6.48e-02 1.70e-01 0.18100 -0.122000 -0.133000 1.01e-01 7.53e-02
RHOA GTPASE CYCLE 143 1.04e-03 7.65e-03 0.18000 0.180000 0.017000 2.12e-04 7.27e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 4.61e-02 1.36e-01 0.18000 -0.132000 0.123000 7.94e-02 1.04e-01
HIV INFECTION 221 2.58e-05 3.66e-04 0.18000 0.012700 0.180000 7.46e-01 4.28e-06
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 2.76e-01 4.53e-01 0.18000 0.178000 -0.023000 1.16e-01 8.39e-01
SIGNALING BY PDGFR IN DISEASE 20 3.55e-01 5.22e-01 0.18000 -0.099700 0.150000 4.40e-01 2.47e-01
PROTEIN FOLDING 88 1.85e-02 7.04e-02 0.18000 0.093800 0.153000 1.28e-01 1.31e-02
ERBB2 ACTIVATES PTK6 SIGNALING 11 6.10e-01 7.29e-01 0.17900 -0.128000 -0.125000 4.61e-01 4.73e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 12 5.57e-01 6.92e-01 0.17900 -0.179000 0.012900 2.84e-01 9.38e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 2.26e-01 3.99e-01 0.17900 -0.174000 0.042400 1.00e-01 6.88e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 62 5.27e-02 1.49e-01 0.17800 0.006820 0.178000 9.26e-01 1.53e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 76 2.49e-02 8.67e-02 0.17800 -0.029900 0.175000 6.53e-01 8.25e-03
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 284 7.10e-07 1.92e-05 0.17800 -0.148000 0.097800 1.73e-05 4.65e-03
SIGNALING BY INTERLEUKINS 345 1.58e-07 4.96e-06 0.17800 0.033200 0.174000 2.90e-01 2.75e-08
DSCAM INTERACTIONS 11 6.11e-01 7.30e-01 0.17700 -0.071500 -0.162000 6.81e-01 3.52e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 1.21e-01 2.58e-01 0.17700 -0.064500 0.164000 4.64e-01 6.21e-02
PLASMA LIPOPROTEIN REMODELING 15 5.07e-01 6.58e-01 0.17600 -0.171000 -0.041200 2.50e-01 7.83e-01
CILIUM ASSEMBLY 189 9.39e-05 1.05e-03 0.17500 0.126000 -0.122000 2.76e-03 3.98e-03
APOPTOTIC FACTOR MEDIATED RESPONSE 18 4.17e-01 5.73e-01 0.17500 -0.068500 0.161000 6.15e-01 2.36e-01
SIGNALING BY MET 75 4.00e-02 1.22e-01 0.17500 0.124000 0.124000 6.29e-02 6.41e-02
UB SPECIFIC PROCESSING PROTEASES 166 4.90e-04 4.05e-03 0.17500 -0.005160 0.175000 9.09e-01 1.02e-04
EXTRACELLULAR MATRIX ORGANIZATION 239 1.54e-05 2.46e-04 0.17500 0.172000 -0.029900 4.79e-06 4.27e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 34 1.94e-01 3.67e-01 0.17300 0.129000 -0.115000 1.92e-01 2.45e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 5.28e-01 6.67e-01 0.17300 -0.173000 0.012900 2.63e-01 9.33e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 6.22e-02 1.66e-01 0.17300 0.162000 -0.060500 3.12e-02 4.22e-01
G2 M CHECKPOINTS 133 2.01e-03 1.27e-02 0.17300 -0.055000 0.164000 2.74e-01 1.09e-03
RHOG GTPASE CYCLE 73 4.58e-02 1.35e-01 0.17300 0.076900 0.155000 2.56e-01 2.25e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 4.70e-01 6.25e-01 0.17300 0.072900 -0.156000 6.14e-01 2.79e-01
ERK MAPK TARGETS 22 3.50e-01 5.20e-01 0.17200 -0.141000 0.099500 2.53e-01 4.19e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 2.53e-01 4.28e-01 0.17200 0.096600 -0.142000 3.68e-01 1.85e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 5.43e-01 6.80e-01 0.17200 -0.149000 0.084500 3.51e-01 5.98e-01
BASIGIN INTERACTIONS 22 3.59e-01 5.24e-01 0.17200 -0.068200 0.157000 5.80e-01 2.01e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 2.69e-01 4.45e-01 0.17100 0.146000 -0.089000 1.80e-01 4.15e-01
ACTIVATION OF BH3 ONLY PROTEINS 28 2.94e-01 4.73e-01 0.17100 -0.171000 -0.007870 1.18e-01 9.43e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.68e-01 4.44e-01 0.17100 -0.118000 0.123000 2.79e-01 2.58e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 138 2.49e-03 1.51e-02 0.17100 0.001960 0.171000 9.68e-01 5.47e-04
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 6.36e-04 4.95e-03 0.17000 0.047100 0.163000 2.80e-01 1.79e-04
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 341 1.75e-07 5.37e-06 0.17000 -0.113000 0.127000 3.57e-04 5.69e-05
CARGO CONCENTRATION IN THE ER 31 2.39e-01 4.14e-01 0.17000 -0.108000 0.131000 2.98e-01 2.08e-01
INTEGRIN CELL SURFACE INTERACTIONS 68 5.05e-02 1.46e-01 0.16900 0.168000 -0.022800 1.67e-02 7.45e-01
ACYL CHAIN REMODELLING OF PG 10 6.31e-01 7.43e-01 0.16900 -0.111000 0.128000 5.44e-01 4.84e-01
CHROMATIN MODIFYING ENZYMES 217 6.26e-05 7.45e-04 0.16900 0.064600 -0.156000 1.02e-01 7.49e-05
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.03e-01 4.77e-01 0.16900 0.109000 0.128000 3.00e-01 2.24e-01
LAMININ INTERACTIONS 27 3.04e-01 4.78e-01 0.16800 0.164000 -0.038900 1.40e-01 7.27e-01
RA BIOSYNTHESIS PATHWAY 12 5.80e-01 7.07e-01 0.16800 -0.093400 0.140000 5.75e-01 4.01e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 3.98e-01 5.57e-01 0.16800 -0.042900 0.162000 7.34e-01 1.98e-01
CDC42 GTPASE CYCLE 153 1.16e-03 8.30e-03 0.16800 0.154000 -0.065800 9.94e-04 1.60e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 5.15e-01 6.62e-01 0.16800 -0.166000 -0.023600 2.51e-01 8.70e-01
O LINKED GLYCOSYLATION 85 3.63e-02 1.14e-01 0.16700 -0.113000 -0.123000 7.14e-02 5.01e-02
SIGNALING BY FGFR1 IN DISEASE 32 2.66e-01 4.41e-01 0.16700 0.012000 0.166000 9.06e-01 1.04e-01
SIGNALING BY FGFR IN DISEASE 55 1.08e-01 2.41e-01 0.16600 0.033500 0.163000 6.67e-01 3.65e-02
METABOLISM OF NUCLEOTIDES 91 1.86e-02 7.06e-02 0.16600 -0.073400 0.149000 2.27e-01 1.39e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 3.14e-01 4.85e-01 0.16600 -0.037500 0.162000 7.36e-01 1.45e-01
PLATELET HOMEOSTASIS 76 3.45e-02 1.11e-01 0.16600 -0.117000 0.118000 7.82e-02 7.53e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 4.35e-01 5.92e-01 0.16600 -0.144000 0.082700 2.78e-01 5.33e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 2.42e-01 4.17e-01 0.16600 -0.013700 0.165000 8.90e-01 9.60e-02
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 3.09e-01 4.81e-01 0.16500 0.020200 0.164000 8.51e-01 1.26e-01
SIGNALING BY VEGF 102 1.62e-02 6.46e-02 0.16500 0.017200 0.165000 7.64e-01 4.12e-03
TOLL LIKE RECEPTOR CASCADES 137 3.35e-03 1.90e-02 0.16500 -0.024500 0.163000 6.22e-01 9.76e-04
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 5.81e-01 7.07e-01 0.16500 -0.070900 -0.149000 6.46e-01 3.34e-01
MTORC1 MEDIATED SIGNALLING 24 3.90e-01 5.51e-01 0.16500 0.052800 0.156000 6.54e-01 1.85e-01
FORMATION OF THE CORNIFIED ENVELOPE 28 2.96e-01 4.73e-01 0.16500 0.131000 -0.099100 2.29e-01 3.64e-01
KERATINIZATION 28 2.96e-01 4.73e-01 0.16500 0.131000 -0.099100 2.29e-01 3.64e-01
AMYLOID FIBER FORMATION 56 9.96e-02 2.27e-01 0.16400 -0.017300 0.163000 8.23e-01 3.44e-02
RND3 GTPASE CYCLE 38 2.16e-01 3.93e-01 0.16400 -0.005580 -0.164000 9.53e-01 8.04e-02
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.49e-01 4.23e-01 0.16400 -0.112000 -0.120000 2.38e-01 2.08e-01
METABOLISM OF CARBOHYDRATES 258 3.18e-05 4.31e-04 0.16400 -0.011300 0.163000 7.54e-01 6.56e-06
CLASS A 1 RHODOPSIN LIKE RECEPTORS 178 5.98e-04 4.71e-03 0.16400 -0.054700 0.154000 2.08e-01 3.92e-04
OTHER SEMAPHORIN INTERACTIONS 19 4.92e-01 6.46e-01 0.16300 -0.106000 -0.124000 4.24e-01 3.49e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 5.52e-01 6.87e-01 0.16300 0.011900 0.163000 9.37e-01 2.76e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 2.24e-01 3.98e-01 0.16300 -0.162000 0.013800 8.73e-02 8.84e-01
RHOC GTPASE CYCLE 73 5.21e-02 1.48e-01 0.16200 0.158000 -0.036100 1.99e-02 5.94e-01
TP53 REGULATES METABOLIC GENES 84 3.16e-02 1.04e-01 0.16200 -0.062300 0.149000 3.24e-01 1.82e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 4.46e-01 6.03e-01 0.16100 0.022900 0.160000 8.56e-01 2.05e-01
RUNX3 REGULATES NOTCH SIGNALING 13 5.99e-01 7.21e-01 0.16100 0.009330 -0.161000 9.54e-01 3.15e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 5.20e-01 6.63e-01 0.16000 -0.075800 -0.141000 5.78e-01 3.00e-01
SIGNALING BY ERBB4 57 1.05e-01 2.35e-01 0.16000 -0.034300 0.156000 6.54e-01 4.13e-02
SIGNALING BY HEDGEHOG 141 6.60e-03 3.19e-02 0.16000 0.128000 0.095600 8.73e-03 5.04e-02
NUCLEOBASE CATABOLISM 31 2.98e-01 4.74e-01 0.15900 -0.025300 0.157000 8.08e-01 1.30e-01
RHOBTB1 GTPASE CYCLE 23 4.42e-01 5.99e-01 0.15900 0.101000 0.123000 4.00e-01 3.09e-01
TRANSLESION SYNTHESIS BY POLK 17 5.20e-01 6.63e-01 0.15900 -0.011700 0.159000 9.34e-01 2.57e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 4.63e-02 1.36e-01 0.15900 -0.117000 0.107000 7.72e-02 1.07e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.18e-01 3.93e-01 0.15900 0.077000 -0.139000 4.12e-01 1.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 3.00e-01 4.75e-01 0.15800 0.122000 -0.099900 2.46e-01 3.44e-01
NEGATIVE REGULATION OF FLT3 14 5.71e-01 7.02e-01 0.15800 0.114000 -0.108000 4.58e-01 4.82e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 2.39e-01 4.14e-01 0.15800 0.092800 0.127000 3.04e-01 1.58e-01
SIGNALING BY FGFR 74 7.78e-02 1.90e-01 0.15700 0.082400 0.133000 2.21e-01 4.77e-02
INTERLEUKIN 35 SIGNALLING 10 7.06e-01 8.00e-01 0.15700 0.071900 0.139000 6.94e-01 4.46e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 1.89e-01 3.63e-01 0.15600 -0.136000 0.076500 1.23e-01 3.86e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 5.78e-01 7.07e-01 0.15600 -0.105000 0.116000 4.98e-01 4.54e-01
PREGNENOLONE BIOSYNTHESIS 12 6.53e-01 7.57e-01 0.15500 0.153000 0.023600 3.57e-01 8.87e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.55e-01 7.58e-01 0.15500 -0.076700 0.135000 6.60e-01 4.38e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 6.16e-01 7.32e-01 0.15500 0.031800 -0.152000 8.43e-01 3.43e-01
ASPARAGINE N LINKED GLYCOSYLATION 283 2.25e-05 3.33e-04 0.15500 -0.076300 0.135000 2.76e-02 9.47e-05
REGULATION OF TNFR1 SIGNALING 34 3.13e-01 4.84e-01 0.15500 0.138000 0.070300 1.63e-01 4.78e-01
MICRORNA MIRNA BIOGENESIS 24 3.95e-01 5.55e-01 0.15500 0.118000 -0.101000 3.18e-01 3.92e-01
CA2 PATHWAY 56 1.18e-01 2.56e-01 0.15500 -0.137000 0.072800 7.69e-02 3.46e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 3.48e-01 5.18e-01 0.15500 0.146000 -0.051700 1.81e-01 6.36e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 5.82e-01 7.07e-01 0.15500 -0.155000 0.002670 3.00e-01 9.86e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 3.16e-01 4.87e-01 0.15500 0.150000 -0.037700 1.49e-01 7.17e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 138 7.55e-03 3.61e-02 0.15500 0.008890 0.154000 8.57e-01 1.77e-03
NEGATIVE REGULATION OF MAPK PATHWAY 43 2.01e-01 3.79e-01 0.15400 -0.048000 0.147000 5.86e-01 9.62e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 3.45e-01 5.16e-01 0.15400 0.077800 -0.133000 4.76e-01 2.23e-01
STIMULI SENSING CHANNELS 74 7.79e-02 1.90e-01 0.15400 -0.038000 -0.149000 5.72e-01 2.63e-02
CARNITINE METABOLISM 14 5.88e-01 7.11e-01 0.15400 -0.111000 0.106000 4.71e-01 4.93e-01
ADAPTIVE IMMUNE SYSTEM 594 4.46e-10 1.86e-08 0.15300 -0.074800 0.134000 1.94e-03 2.81e-08
SIGNALING BY WNT 266 1.01e-04 1.11e-03 0.15300 0.003760 0.153000 9.16e-01 1.83e-05
OLFACTORY SIGNALING PATHWAY 23 4.62e-01 6.17e-01 0.15300 0.054400 0.143000 6.51e-01 2.36e-01
G2 M DNA DAMAGE CHECKPOINT 65 1.00e-01 2.28e-01 0.15300 -0.152000 0.011700 3.38e-02 8.70e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 93 3.16e-02 1.04e-01 0.15300 -0.079400 0.130000 1.86e-01 2.98e-02
PECAM1 INTERACTIONS 12 6.63e-01 7.63e-01 0.15300 0.024400 0.151000 8.84e-01 3.66e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 2.64e-01 4.39e-01 0.15200 -0.091200 0.121000 3.44e-01 2.07e-01
SIGNALING BY PTK6 50 1.90e-01 3.64e-01 0.15200 0.047700 0.144000 5.59e-01 7.79e-02
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 43 2.50e-01 4.24e-01 0.15200 -0.111000 -0.103000 2.07e-01 2.42e-01
SYNTHESIS OF PE 12 6.66e-01 7.66e-01 0.15200 -0.026300 -0.149000 8.75e-01 3.70e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 8.84e-02 2.07e-01 0.15100 -0.146000 -0.039100 3.07e-02 5.64e-01
STRIATED MUSCLE CONTRACTION 26 3.84e-01 5.46e-01 0.15100 0.120000 -0.092300 2.90e-01 4.15e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 5.78e-01 7.07e-01 0.15100 0.126000 -0.083800 4.00e-01 5.74e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 5.10e-01 6.59e-01 0.15100 -0.150000 -0.020200 2.47e-01 8.76e-01
SIGNALING BY PDGF 55 1.38e-01 2.84e-01 0.15100 0.139000 -0.059900 7.56e-02 4.42e-01
GPCR LIGAND BINDING 259 1.06e-04 1.14e-03 0.15100 -0.055100 0.140000 1.28e-01 1.03e-04
EGFR DOWNREGULATION 28 3.59e-01 5.24e-01 0.15100 -0.101000 0.112000 3.57e-01 3.04e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 1.92e-01 3.66e-01 0.15100 0.137000 -0.061700 1.07e-01 4.69e-01
CA DEPENDENT EVENTS 36 2.75e-01 4.52e-01 0.15000 -0.137000 0.061700 1.54e-01 5.22e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 3.23e-01 4.96e-01 0.15000 -0.057400 -0.139000 5.57e-01 1.55e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 5.97e-01 7.19e-01 0.15000 0.052200 0.140000 7.18e-01 3.31e-01
RND1 GTPASE CYCLE 38 3.04e-01 4.78e-01 0.15000 -0.103000 -0.109000 2.73e-01 2.46e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 9.24e-03 4.19e-02 0.14900 -0.069600 0.132000 1.66e-01 8.61e-03
SIGNALING BY ERBB2 IN CANCER 25 4.09e-01 5.65e-01 0.14900 -0.101000 0.110000 3.82e-01 3.42e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 6.36e-01 7.45e-01 0.14900 0.033100 0.145000 8.30e-01 3.47e-01
ASSEMBLY OF THE HIV VIRION 16 6.10e-01 7.29e-01 0.14900 0.100000 0.109000 4.87e-01 4.49e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 6.53e-01 7.57e-01 0.14800 -0.094100 0.115000 5.73e-01 4.91e-01
DUAL INCISION IN GG NER 40 2.91e-01 4.70e-01 0.14800 0.094300 0.115000 3.02e-01 2.10e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 1.73e-01 3.40e-01 0.14800 -0.122000 -0.084500 1.12e-01 2.70e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 4.38e-01 5.95e-01 0.14800 -0.046800 0.140000 6.91e-01 2.34e-01
SIGNALING BY ERBB2 48 2.07e-01 3.85e-01 0.14700 -0.006000 0.147000 9.43e-01 7.76e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 4.03e-01 5.60e-01 0.14700 0.098200 -0.110000 3.86e-01 3.32e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 4.68e-01 6.23e-01 0.14700 -0.109000 -0.099400 3.47e-01 3.90e-01
ACYL CHAIN REMODELLING OF PS 14 6.40e-01 7.49e-01 0.14700 -0.145000 -0.022500 3.47e-01 8.84e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 1.17e-01 2.54e-01 0.14700 -0.091000 0.115000 2.16e-01 1.17e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 5.09e-01 6.59e-01 0.14600 -0.137000 0.051100 2.88e-01 6.92e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.99e-01 7.21e-01 0.14600 -0.069200 0.129000 6.43e-01 3.87e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 3.88e-01 5.49e-01 0.14600 -0.053500 -0.136000 6.06e-01 1.91e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 4.87e-01 6.43e-01 0.14500 -0.029300 0.143000 8.12e-01 2.47e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 2.95e-01 4.73e-01 0.14500 0.138000 -0.045300 1.47e-01 6.33e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.88e-01 7.11e-01 0.14500 -0.131000 0.061500 3.65e-01 6.70e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 5.05e-01 6.56e-01 0.14400 -0.039700 0.139000 7.53e-01 2.71e-01
RNA POLYMERASE I TRANSCRIPTION 67 1.36e-01 2.81e-01 0.14400 0.133000 0.055200 5.89e-02 4.35e-01
HS GAG BIOSYNTHESIS 29 3.87e-01 5.49e-01 0.14400 -0.048100 0.136000 6.54e-01 2.05e-01
CELL JUNCTION ORGANIZATION 75 8.37e-02 2.00e-01 0.14400 -0.125000 0.071300 6.07e-02 2.86e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 2.43e-01 4.17e-01 0.14400 -0.058600 0.132000 5.07e-01 1.35e-01
LEISHMANIA INFECTION 193 2.39e-03 1.48e-02 0.14300 -0.022600 0.142000 5.88e-01 7.09e-04
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 2.08e-01 3.85e-01 0.14300 0.038300 0.138000 6.30e-01 8.29e-02
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 6.38e-02 1.68e-01 0.14300 0.106000 -0.095600 9.24e-02 1.30e-01
CHOLESTEROL BIOSYNTHESIS 24 4.55e-01 6.11e-01 0.14300 -0.092300 0.109000 4.34e-01 3.55e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 1.58e-01 3.17e-01 0.14300 0.140000 0.028200 5.69e-02 7.01e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 6.76e-01 7.74e-01 0.14200 -0.013400 -0.142000 9.33e-01 3.76e-01
RHOV GTPASE CYCLE 32 4.02e-01 5.58e-01 0.14200 -0.069600 -0.124000 4.96e-01 2.26e-01
SURFACTANT METABOLISM 16 6.23e-01 7.36e-01 0.14200 0.025200 0.140000 8.61e-01 3.34e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 4.14e-01 5.70e-01 0.14200 -0.010700 0.141000 9.21e-01 1.89e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 90 5.81e-02 1.59e-01 0.14100 -0.062600 0.127000 3.05e-01 3.78e-02
RNA POLYMERASE III TRANSCRIPTION 41 2.71e-01 4.47e-01 0.14100 0.082800 -0.114000 3.59e-01 2.06e-01
HEMOSTASIS 471 1.67e-06 3.90e-05 0.14100 0.029900 0.138000 2.67e-01 3.36e-07
POTENTIAL THERAPEUTICS FOR SARS 76 1.23e-01 2.60e-01 0.14100 0.100000 0.098500 1.30e-01 1.38e-01
ERBB2 REGULATES CELL MOTILITY 14 6.53e-01 7.57e-01 0.14100 -0.139000 0.024300 3.70e-01 8.75e-01
DNA STRAND ELONGATION 32 3.73e-01 5.36e-01 0.14100 -0.038500 0.135000 7.06e-01 1.86e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 17 6.13e-01 7.30e-01 0.14000 -0.031200 -0.137000 8.24e-01 3.28e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 4.90e-01 6.46e-01 0.14000 -0.004620 0.140000 9.69e-01 2.35e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 4.00e-01 5.58e-01 0.14000 0.136000 0.033500 1.82e-01 7.43e-01
CELL CYCLE CHECKPOINTS 241 7.10e-04 5.41e-03 0.14000 -0.034700 0.136000 3.55e-01 2.94e-04
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 45 2.92e-01 4.71e-01 0.14000 0.106000 0.091500 2.19e-01 2.89e-01
RHOB GTPASE CYCLE 67 1.31e-01 2.75e-01 0.14000 0.135000 -0.035400 5.58e-02 6.16e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 4.30e-01 5.88e-01 0.14000 -0.007100 -0.139000 9.47e-01 1.94e-01
ZINC TRANSPORTERS 15 6.26e-01 7.38e-01 0.13900 -0.086600 0.109000 5.61e-01 4.64e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 15 6.36e-01 7.45e-01 0.13900 -0.135000 0.033700 3.65e-01 8.21e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 4.90e-01 6.46e-01 0.13900 0.077800 -0.115000 5.18e-01 3.38e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 6.26e-01 7.38e-01 0.13900 -0.139000 0.006710 3.36e-01 9.63e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 1.85e-01 3.58e-01 0.13900 -0.120000 -0.069700 1.02e-01 3.43e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 2.21e-01 3.96e-01 0.13900 -0.092100 0.103000 2.65e-01 2.10e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 6.46e-01 7.53e-01 0.13700 0.135000 -0.023300 3.64e-01 8.76e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 1.31e-01 2.75e-01 0.13700 -0.049100 0.128000 4.81e-01 6.65e-02
DEADENYLATION OF MRNA 25 4.96e-01 6.49e-01 0.13700 -0.137000 -0.004680 2.37e-01 9.68e-01
HCMV EARLY EVENTS 79 9.37e-02 2.16e-01 0.13700 0.107000 -0.085400 1.01e-01 1.90e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 5.91e-01 7.13e-01 0.13700 0.072500 0.116000 5.75e-01 3.70e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 9.26e-02 2.14e-01 0.13700 -0.026000 0.134000 6.82e-01 3.49e-02
RHO GTPASE EFFECTORS 247 1.50e-03 9.96e-03 0.13600 0.050900 0.127000 1.69e-01 6.23e-04
RIPK1 MEDIATED REGULATED NECROSIS 25 5.01e-01 6.53e-01 0.13600 0.013400 0.136000 9.07e-01 2.40e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 1.53e-01 3.07e-01 0.13600 -0.100000 0.092700 1.70e-01 2.03e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.80e-01 7.07e-01 0.13600 -0.079500 -0.110000 5.28e-01 3.82e-01
SIGNALING BY EGFR 47 2.77e-01 4.54e-01 0.13600 0.015800 0.135000 8.52e-01 1.09e-01
DNA DAMAGE RECOGNITION IN GG NER 38 3.55e-01 5.22e-01 0.13500 0.011800 0.135000 9.00e-01 1.50e-01
HIV ELONGATION ARREST AND RECOVERY 32 4.20e-01 5.76e-01 0.13500 0.135000 0.012000 1.88e-01 9.07e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 8.02e-02 1.93e-01 0.13500 -0.067500 0.117000 2.77e-01 5.94e-02
SIGNALING BY LEPTIN 10 7.50e-01 8.37e-01 0.13500 0.050300 -0.125000 7.83e-01 4.93e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 49 2.58e-01 4.33e-01 0.13500 -0.133000 0.017000 1.06e-01 8.36e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 1.95e-01 3.68e-01 0.13400 -0.011900 -0.134000 8.72e-01 7.05e-02
DEFECTS IN COBALAMIN B12 METABOLISM 12 7.32e-01 8.24e-01 0.13400 0.033600 0.129000 8.40e-01 4.38e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 6.84e-01 7.81e-01 0.13300 -0.008840 0.133000 9.54e-01 3.88e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 7.63e-01 8.47e-01 0.13300 0.133000 -0.006590 4.66e-01 9.71e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 3.36e-01 5.10e-01 0.13300 0.090000 0.098000 3.02e-01 2.61e-01
SIGNALING BY NTRK2 TRKB 24 5.09e-01 6.59e-01 0.13300 -0.113000 0.068900 3.36e-01 5.59e-01
RECYCLING PATHWAY OF L1 40 3.73e-01 5.36e-01 0.13300 0.083800 0.103000 3.59e-01 2.61e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 4.59e-01 6.16e-01 0.13200 -0.046400 -0.124000 6.55e-01 2.33e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 4.25e-01 5.81e-01 0.13200 0.129000 -0.024900 2.06e-01 8.08e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.21e-01 2.58e-01 0.13200 -0.043500 -0.124000 4.88e-01 4.79e-02
FGFR1 MUTANT RECEPTOR ACTIVATION 25 5.46e-01 6.82e-01 0.13100 0.077100 0.106000 5.05e-01 3.58e-01
RND2 GTPASE CYCLE 38 3.73e-01 5.36e-01 0.13100 0.011200 -0.130000 9.05e-01 1.65e-01
NERVOUS SYSTEM DEVELOPMENT 546 3.36e-06 7.25e-05 0.13000 0.091400 0.093100 2.76e-04 2.11e-04
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 3.88e-01 5.49e-01 0.13000 0.077800 -0.104000 4.26e-01 2.87e-01
RESOLUTION OF ABASIC SITES AP SITES 37 3.86e-01 5.48e-01 0.13000 0.128000 -0.018900 1.78e-01 8.42e-01
SIGNALING BY SCF KIT 41 3.53e-01 5.22e-01 0.12900 -0.129000 0.011600 1.54e-01 8.98e-01
INTERLEUKIN 6 FAMILY SIGNALING 18 6.35e-01 7.45e-01 0.12900 0.129000 -0.009560 3.45e-01 9.44e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 1.39e-01 2.85e-01 0.12900 -0.121000 -0.044400 5.71e-02 4.85e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 37 4.13e-01 5.70e-01 0.12900 0.041000 0.122000 6.66e-01 1.99e-01
DEUBIQUITINATION 240 2.64e-03 1.58e-02 0.12800 -0.012200 0.128000 7.46e-01 6.76e-04
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 4.17e-01 5.73e-01 0.12800 0.067400 0.109000 4.72e-01 2.47e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 114 6.04e-02 1.63e-01 0.12800 -0.007480 0.128000 8.90e-01 1.88e-02
RESOLUTION OF SISTER CHROMATID COHESION 100 1.01e-01 2.28e-01 0.12800 0.062400 0.111000 2.81e-01 5.45e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 6.91e-01 7.86e-01 0.12800 0.127000 -0.006200 3.93e-01 9.67e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 4.60e-01 6.16e-01 0.12700 -0.025300 0.125000 8.07e-01 2.29e-01
SIGNALING BY NUCLEAR RECEPTORS 219 4.45e-03 2.39e-02 0.12600 -0.042800 0.119000 2.76e-01 2.51e-03
NETRIN 1 SIGNALING 49 3.37e-01 5.11e-01 0.12600 -0.090100 -0.088100 2.76e-01 2.86e-01
MET PROMOTES CELL MOTILITY 39 3.96e-01 5.55e-01 0.12600 0.126000 0.003540 1.74e-01 9.70e-01
PHOSPHORYLATION OF THE APC C 17 6.55e-01 7.58e-01 0.12600 -0.118000 0.042800 3.99e-01 7.60e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.58e-01 5.24e-01 0.12600 0.055100 -0.113000 5.42e-01 2.11e-01
SYNTHESIS OF PA 29 5.24e-01 6.65e-01 0.12500 0.057300 0.112000 5.93e-01 2.99e-01
AMINO ACIDS REGULATE MTORC1 51 3.00e-01 4.75e-01 0.12500 0.000902 0.125000 9.91e-01 1.22e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.85e-01 8.62e-01 0.12500 -0.123000 0.021600 4.99e-01 9.06e-01
PEPTIDE LIGAND BINDING RECEPTORS 101 8.78e-02 2.06e-01 0.12500 -0.024200 0.123000 6.74e-01 3.31e-02
NEPHRIN FAMILY INTERACTIONS 22 6.12e-01 7.30e-01 0.12400 0.118000 0.039600 3.38e-01 7.48e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 5.96e-01 7.18e-01 0.12400 -0.063200 0.107000 6.16e-01 3.96e-01
SIGNAL TRANSDUCTION BY L1 21 6.20e-01 7.34e-01 0.12400 0.019700 0.123000 8.76e-01 3.31e-01
GLYCOSAMINOGLYCAN METABOLISM 114 6.21e-02 1.66e-01 0.12400 -0.059500 0.109000 2.73e-01 4.48e-02
POST TRANSLATIONAL PROTEIN MODIFICATION 1205 9.65e-13 4.89e-11 0.12400 -0.081700 0.093100 2.25e-06 6.86e-08
INTRA GOLGI TRAFFIC 43 3.67e-01 5.32e-01 0.12300 -0.122000 0.015600 1.65e-01 8.59e-01
G ALPHA Q SIGNALLING EVENTS 154 3.01e-02 1.01e-01 0.12300 -0.000981 0.123000 9.83e-01 8.32e-03
ORGANELLE BIOGENESIS AND MAINTENANCE 281 1.22e-03 8.57e-03 0.12300 0.107000 -0.062000 2.16e-03 7.44e-02
INTRINSIC PATHWAY FOR APOPTOSIS 50 2.96e-01 4.73e-01 0.12300 -0.078600 0.094800 3.36e-01 2.46e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 536 4.36e-06 8.76e-05 0.12300 -0.041300 0.116000 1.03e-01 4.92e-06
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 175 1.67e-02 6.60e-02 0.12300 -0.118000 0.035500 7.33e-03 4.18e-01
RNA POLYMERASE III CHAIN ELONGATION 18 6.49e-01 7.55e-01 0.12300 0.105000 -0.063900 4.42e-01 6.39e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 7.93e-01 8.66e-01 0.12200 0.058200 0.107000 7.38e-01 5.38e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 7.78e-01 8.58e-01 0.12200 0.071200 0.098900 6.69e-01 5.53e-01
TRAFFICKING OF AMPA RECEPTORS 31 4.93e-01 6.46e-01 0.12200 0.018300 -0.120000 8.60e-01 2.46e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 4.24e-01 5.81e-01 0.12100 0.110000 0.049700 2.21e-01 5.82e-01
METABOLISM OF LIPIDS 608 1.98e-06 4.52e-05 0.12100 -0.015200 0.120000 5.23e-01 4.95e-07
SIGNALLING TO ERKS 34 4.50e-01 6.07e-01 0.12100 -0.093300 0.076700 3.46e-01 4.39e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 2.08e-01 3.85e-01 0.12100 -0.120000 0.011500 8.04e-02 8.67e-01
ESR MEDIATED SIGNALING 163 2.45e-02 8.59e-02 0.12000 -0.064400 0.101000 1.56e-01 2.64e-02
DOWNREGULATION OF ERBB2 SIGNALING 28 5.68e-01 7.02e-01 0.11900 0.047100 0.109000 6.66e-01 3.17e-01
RHOJ GTPASE CYCLE 54 3.24e-01 4.96e-01 0.11900 0.016500 0.118000 8.34e-01 1.34e-01
RAC1 GTPASE CYCLE 177 2.69e-02 9.26e-02 0.11900 0.116000 0.027900 8.03e-03 5.22e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 6.41e-01 7.49e-01 0.11900 -0.119000 -0.001390 3.47e-01 9.91e-01
SIGNALING BY NTRKS 131 5.31e-02 1.50e-01 0.11800 -0.083800 0.083500 9.78e-02 9.91e-02
MAPK FAMILY SIGNALING CASCADES 287 3.41e-03 1.91e-02 0.11800 0.036700 0.112000 2.85e-01 1.10e-03
RORA ACTIVATES GENE EXPRESSION 18 6.87e-01 7.83e-01 0.11800 0.001390 -0.118000 9.92e-01 3.88e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 3.02e-01 4.77e-01 0.11800 0.117000 -0.009690 1.26e-01 8.99e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.16e-01 7.32e-01 0.11700 0.101000 0.059900 3.84e-01 6.04e-01
TBC RABGAPS 43 4.01e-01 5.58e-01 0.11700 -0.026800 0.114000 7.61e-01 1.96e-01
INTERLEUKIN 15 SIGNALING 12 7.86e-01 8.62e-01 0.11600 -0.115000 -0.016000 4.89e-01 9.24e-01
METABOLISM OF FOLATE AND PTERINES 15 7.47e-01 8.35e-01 0.11600 0.108000 0.043900 4.70e-01 7.69e-01
PTEN REGULATION 134 8.11e-02 1.95e-01 0.11600 0.079700 0.084400 1.12e-01 9.19e-02
EPH EPHRIN SIGNALING 90 1.52e-01 3.07e-01 0.11600 -0.033800 0.111000 5.80e-01 6.92e-02
INTEGRATION OF ENERGY METABOLISM 98 1.50e-01 3.03e-01 0.11500 0.023000 0.113000 6.95e-01 5.33e-02
SIGNALING BY NODAL 15 7.43e-01 8.32e-01 0.11500 0.008290 0.115000 9.56e-01 4.41e-01
TNF SIGNALING 43 4.51e-01 6.07e-01 0.11500 0.083400 0.079300 3.44e-01 3.68e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 3.29e-01 5.03e-01 0.11500 -0.053700 0.102000 4.99e-01 2.01e-01
FANCONI ANEMIA PATHWAY 36 4.73e-01 6.29e-01 0.11500 0.048400 -0.104000 6.15e-01 2.81e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 5.32e-01 6.69e-01 0.11400 -0.030900 0.110000 7.66e-01 2.89e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 169 3.09e-02 1.02e-01 0.11400 -0.070200 0.089400 1.16e-01 4.52e-02
TRANSPORT OF SMALL MOLECULES 565 1.53e-05 2.46e-04 0.11300 -0.041300 0.106000 9.51e-02 1.90e-05
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 2.84e-01 4.62e-01 0.11300 -0.027800 0.110000 7.03e-01 1.31e-01
SLC TRANSPORTER DISORDERS 69 2.50e-01 4.24e-01 0.11300 -0.105000 0.041100 1.31e-01 5.55e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 7.93e-01 8.66e-01 0.11300 0.077400 0.082300 6.29e-01 6.07e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 1.59e-01 3.18e-01 0.11300 -0.033800 0.107000 5.73e-01 7.34e-02
CHONDROITIN SULFATE BIOSYNTHESIS 19 6.80e-01 7.76e-01 0.11300 -0.065300 0.091700 6.22e-01 4.89e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.29e-01 4.04e-01 0.11200 -0.006250 0.112000 9.24e-01 8.85e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 10 8.35e-01 8.99e-01 0.11200 0.038900 0.105000 8.31e-01 5.65e-01
G PROTEIN MEDIATED EVENTS 52 3.53e-01 5.22e-01 0.11200 -0.062100 0.093100 4.38e-01 2.45e-01
SEMAPHORIN INTERACTIONS 64 2.78e-01 4.54e-01 0.11200 0.093800 -0.061100 1.95e-01 3.98e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 7.75e-01 8.55e-01 0.11200 0.028400 0.108000 8.54e-01 4.84e-01
NUCLEAR ENVELOPE NE REASSEMBLY 63 3.33e-01 5.06e-01 0.11200 0.074800 0.083000 3.05e-01 2.55e-01
TRNA PROCESSING 105 1.31e-01 2.74e-01 0.11200 0.032700 -0.107000 5.63e-01 5.90e-02
GLUCOSE METABOLISM 80 2.34e-01 4.08e-01 0.11100 0.016900 0.110000 7.93e-01 8.95e-02
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 5.33e-01 6.70e-01 0.11100 -0.002990 -0.111000 9.76e-01 2.62e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 7.79e-01 8.58e-01 0.11100 0.108000 -0.027200 5.02e-01 8.65e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 7.38e-01 8.27e-01 0.11000 0.062800 0.089800 6.45e-01 5.09e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 1.80e-01 3.52e-01 0.10900 -0.043200 0.100000 4.76e-01 9.79e-02
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 8.36e-01 8.99e-01 0.10900 0.001630 0.109000 9.93e-01 5.50e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 4.62e-01 6.17e-01 0.10900 -0.104000 -0.033500 2.28e-01 6.97e-01
BASE EXCISION REPAIR 56 3.60e-01 5.24e-01 0.10900 0.107000 -0.020500 1.66e-01 7.91e-01
SENSORY PROCESSING OF SOUND 61 3.48e-01 5.18e-01 0.10900 0.107000 0.021200 1.50e-01 7.75e-01
RHOU GTPASE CYCLE 33 5.70e-01 7.02e-01 0.10800 -0.105000 -0.026800 2.97e-01 7.90e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 5.83e-01 7.08e-01 0.10800 -0.080600 -0.072000 4.23e-01 4.74e-01
NICOTINAMIDE SALVAGING 15 7.56e-01 8.41e-01 0.10800 0.091300 -0.057400 5.40e-01 7.00e-01
POTASSIUM CHANNELS 90 2.18e-01 3.93e-01 0.10800 -0.106000 -0.021900 8.36e-02 7.20e-01
RAC2 GTPASE CYCLE 86 2.48e-01 4.22e-01 0.10700 0.045500 0.096800 4.67e-01 1.21e-01
MITOTIC PROPHASE 92 1.96e-01 3.70e-01 0.10500 -0.089800 0.055400 1.37e-01 3.59e-01
NUCLEOTIDE EXCISION REPAIR 109 1.54e-01 3.10e-01 0.10500 -0.027500 0.102000 6.21e-01 6.72e-02
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 5.19e-01 6.63e-01 0.10500 -0.044500 -0.094900 6.18e-01 2.88e-01
DUAL INCISION IN TC NER 64 3.48e-01 5.18e-01 0.10400 -0.005080 0.104000 9.44e-01 1.49e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 6.09e-01 7.29e-01 0.10400 0.070000 0.076300 4.86e-01 4.48e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 2.10e-01 3.85e-01 0.10400 -0.044500 0.093500 4.61e-01 1.21e-01
MITOTIC G2 G2 M PHASES 184 6.31e-02 1.68e-01 0.10400 0.090200 0.050700 3.50e-02 2.36e-01
RHO GTPASES ACTIVATE FORMINS 118 1.68e-01 3.32e-01 0.10300 0.041900 0.094400 4.32e-01 7.69e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS 20 7.25e-01 8.18e-01 0.10300 -0.103000 0.002700 4.25e-01 9.83e-01
MEIOTIC SYNAPSIS 39 5.25e-01 6.66e-01 0.10200 0.096200 -0.035300 2.99e-01 7.03e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 6.17e-01 7.32e-01 0.10200 -0.070400 0.073500 5.12e-01 4.94e-01
FLT3 SIGNALING 36 5.69e-01 7.02e-01 0.10200 -0.101000 0.008850 2.94e-01 9.27e-01
RAB REGULATION OF TRAFFICKING 118 1.48e-01 3.01e-01 0.10100 -0.040900 0.092700 4.43e-01 8.21e-02
REGULATION OF PTEN GENE TRANSCRIPTION 59 3.80e-01 5.41e-01 0.10100 0.078600 -0.063600 2.97e-01 3.98e-01
HIV TRANSCRIPTION INITIATION 45 4.93e-01 6.46e-01 0.10100 -0.019400 0.099100 8.22e-01 2.50e-01
NUCLEAR IMPORT OF REV PROTEIN 32 6.34e-01 7.45e-01 0.10000 -0.042200 -0.090700 6.79e-01 3.75e-01
CELL CELL COMMUNICATION 107 1.81e-01 3.53e-01 0.09990 -0.078200 0.062200 1.63e-01 2.66e-01
SIGNALING BY GPCR 476 6.45e-04 4.98e-03 0.09990 -0.044500 0.089500 9.76e-02 8.60e-04
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 3.09e-01 4.81e-01 0.09970 0.082900 -0.055400 2.18e-01 4.10e-01
MITOTIC SPINDLE CHECKPOINT 96 2.34e-01 4.08e-01 0.09960 -0.013300 0.098700 8.22e-01 9.50e-02
MEIOTIC RECOMBINATION 38 5.62e-01 6.96e-01 0.09910 -0.096800 0.020900 3.02e-01 8.24e-01
EFFECTS OF PIP2 HYDROLYSIS 27 6.61e-01 7.62e-01 0.09850 0.037500 -0.091100 7.36e-01 4.13e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 7.15e-01 8.09e-01 0.09840 -0.001300 0.098400 9.91e-01 4.14e-01
REGULATION OF INSULIN SECRETION 71 3.55e-01 5.22e-01 0.09820 -0.006310 0.098000 9.27e-01 1.54e-01
METABOLISM OF STEROIDS 111 2.10e-01 3.85e-01 0.09760 0.008740 0.097200 8.74e-01 7.71e-02
NEUROTRANSMITTER RELEASE CYCLE 48 5.19e-01 6.63e-01 0.09730 0.027900 0.093200 7.39e-01 2.64e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 6.32e-01 7.44e-01 0.09710 0.096000 0.014600 3.40e-01 8.84e-01
INTERLEUKIN 17 SIGNALING 66 3.78e-01 5.40e-01 0.09700 -0.091300 0.032900 2.00e-01 6.44e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 8.64e-01 9.14e-01 0.09640 -0.039900 -0.087700 8.19e-01 6.15e-01
INOSITOL PHOSPHATE METABOLISM 47 5.45e-01 6.82e-01 0.09610 0.062700 0.072800 4.57e-01 3.88e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 8.41e-01 9.01e-01 0.09600 0.032200 0.090500 8.41e-01 5.72e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 8.04e-01 8.74e-01 0.09590 0.088200 -0.037700 5.54e-01 8.01e-01
DEVELOPMENTAL BIOLOGY 809 5.10e-05 6.33e-04 0.09570 0.069400 0.065900 8.60e-04 1.54e-03
MEMBRANE TRAFFICKING 579 3.48e-04 3.03e-03 0.09490 -0.036400 0.087700 1.36e-01 3.31e-04
DISEASES OF METABOLISM 198 8.44e-02 2.01e-01 0.09480 0.076900 0.055300 6.23e-02 1.80e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.29e-01 8.95e-01 0.09440 0.058900 0.073700 6.93e-01 6.21e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 3.60e-01 5.24e-01 0.09430 -0.087400 0.035600 1.97e-01 6.00e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 5.88e-01 7.11e-01 0.09360 0.012000 0.092800 8.94e-01 3.04e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.04e-01 8.74e-01 0.09350 0.023200 -0.090600 8.72e-01 5.31e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 365 9.03e-03 4.11e-02 0.09320 -0.005100 0.093000 8.67e-01 2.33e-03
SIGNALING BY NOTCH2 33 6.70e-01 7.68e-01 0.09320 -0.068900 -0.062700 4.93e-01 5.33e-01
MYOGENESIS 25 7.38e-01 8.27e-01 0.09280 -0.046000 -0.080600 6.91e-01 4.86e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 235 4.12e-02 1.25e-01 0.09270 -0.077300 0.051000 4.15e-02 1.78e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 4.18e-01 5.73e-01 0.09260 0.019000 -0.090600 7.89e-01 2.03e-01
NUCLEOTIDE SALVAGE 21 7.74e-01 8.55e-01 0.09180 -0.087600 -0.027200 4.87e-01 8.29e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 6.45e-01 7.52e-01 0.09160 -0.078500 -0.047300 4.09e-01 6.19e-01
SIGNALLING TO RAS 20 7.64e-01 8.47e-01 0.09140 0.066400 -0.062900 6.08e-01 6.26e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 4.90e-01 6.46e-01 0.09100 0.047400 -0.077600 5.47e-01 3.24e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 7.49e-01 8.37e-01 0.09000 -0.020000 0.087700 8.68e-01 4.67e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 2.65e-01 4.40e-01 0.08990 0.073000 -0.052500 2.01e-01 3.57e-01
APOPTOTIC EXECUTION PHASE 45 5.63e-01 6.96e-01 0.08970 -0.041200 0.079700 6.33e-01 3.55e-01
GENE SILENCING BY RNA 83 3.78e-01 5.40e-01 0.08940 -0.014700 -0.088200 8.17e-01 1.65e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 7.26e-01 8.18e-01 0.08930 0.033200 0.082900 7.61e-01 4.48e-01
OXIDATIVE STRESS INDUCED SENESCENCE 78 3.78e-01 5.40e-01 0.08900 0.033300 -0.082500 6.11e-01 2.08e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 6.60e-01 7.62e-01 0.08870 -0.087500 -0.014500 3.64e-01 8.80e-01
MITOCHONDRIAL BIOGENESIS 92 3.68e-01 5.33e-01 0.08820 0.063500 0.061200 2.92e-01 3.10e-01
CARDIAC CONDUCTION 108 3.05e-01 4.78e-01 0.08820 -0.078000 -0.041200 1.62e-01 4.59e-01
HS GAG DEGRADATION 20 7.96e-01 8.68e-01 0.08780 -0.011400 -0.087100 9.30e-01 5.00e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 3.14e-01 4.85e-01 0.08760 -0.042800 -0.076400 4.44e-01 1.72e-01
HIV LIFE CYCLE 143 2.08e-01 3.85e-01 0.08760 0.028500 0.082800 5.56e-01 8.78e-02
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 8.74e-01 9.22e-01 0.08710 -0.086200 -0.012400 6.05e-01 9.41e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 7.86e-01 8.62e-01 0.08660 0.059700 -0.062700 6.44e-01 6.27e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 463 7.14e-03 3.44e-02 0.08650 0.016800 0.084800 5.37e-01 1.82e-03
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 5.82e-01 7.07e-01 0.08650 0.011200 0.085800 8.93e-01 2.99e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 6.12e-01 7.30e-01 0.08630 0.069400 0.051300 4.10e-01 5.43e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 7.96e-01 8.68e-01 0.08620 0.085100 -0.013500 5.10e-01 9.17e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 6.94e-01 7.89e-01 0.08610 0.046400 0.072600 6.35e-01 4.58e-01
HATS ACETYLATE HISTONES 91 3.80e-01 5.41e-01 0.08610 -0.028600 -0.081200 6.37e-01 1.81e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 5.73e-01 7.03e-01 0.08570 -0.034900 0.078300 6.76e-01 3.48e-01
VESICLE MEDIATED TRANSPORT 607 1.22e-03 8.57e-03 0.08560 -0.023700 0.082300 3.20e-01 5.68e-04
TRANSCRIPTION OF THE HIV GENOME 67 5.10e-01 6.59e-01 0.08470 0.050200 0.068200 4.77e-01 3.34e-01
NICOTINATE METABOLISM 24 7.59e-01 8.43e-01 0.08470 0.071500 -0.045400 5.44e-01 7.00e-01
METABOLISM OF VITAMINS AND COFACTORS 148 2.23e-01 3.98e-01 0.08440 0.030000 0.078900 5.29e-01 9.79e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 8.92e-01 9.32e-01 0.08440 0.053800 -0.065000 7.68e-01 7.22e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 5.27e-01 6.67e-01 0.08380 0.017400 -0.082000 8.17e-01 2.76e-01
DNA REPAIR 291 5.93e-02 1.61e-01 0.08380 -0.048100 -0.068600 1.59e-01 4.46e-02
THE PHOTOTRANSDUCTION CASCADE 20 7.98e-01 8.70e-01 0.08370 -0.061200 0.057000 6.35e-01 6.59e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 2.86e-03 1.70e-02 0.08310 0.060400 0.057100 1.01e-02 1.51e-02
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 61 5.09e-01 6.59e-01 0.08310 -0.064100 0.052900 3.87e-01 4.75e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 7.52e-01 8.38e-01 0.08300 -0.010100 0.082400 9.27e-01 4.59e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 3.57e-01 5.23e-01 0.08260 0.070600 -0.042900 2.35e-01 4.70e-01
M PHASE 336 4.19e-02 1.26e-01 0.08200 0.031500 0.075700 3.23e-01 1.73e-02
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 9.03e-01 9.37e-01 0.08130 0.063400 0.050900 7.16e-01 7.70e-01
PI3K AKT SIGNALING IN CANCER 88 3.94e-01 5.54e-01 0.08130 -0.062700 0.051800 3.10e-01 4.01e-01
PRE NOTCH EXPRESSION AND PROCESSING 63 5.29e-01 6.67e-01 0.08130 0.011900 -0.080400 8.70e-01 2.70e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 5.47e-01 6.82e-01 0.08130 0.068700 0.043300 3.38e-01 5.46e-01
VISUAL PHOTOTRANSDUCTION 58 5.54e-01 6.90e-01 0.08070 -0.076900 0.024400 3.11e-01 7.48e-01
MTOR SIGNALLING 40 6.67e-01 7.67e-01 0.08070 -0.020100 0.078100 8.26e-01 3.93e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 8.64e-01 9.14e-01 0.08060 0.045300 0.066700 7.54e-01 6.44e-01
NUCLEAR SIGNALING BY ERBB4 31 7.54e-01 8.39e-01 0.08050 0.049600 0.063400 6.33e-01 5.41e-01
DISEASES OF PROGRAMMED CELL DEATH 54 6.18e-01 7.32e-01 0.07980 0.056200 0.056600 4.75e-01 4.72e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 6.61e-01 7.62e-01 0.07920 0.045600 0.064800 5.89e-01 4.43e-01
GAB1 SIGNALOSOME 14 8.83e-01 9.26e-01 0.07860 0.027100 0.073800 8.61e-01 6.32e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 7.99e-01 8.70e-01 0.07840 0.032600 -0.071300 7.87e-01 5.54e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 4.01e-01 5.58e-01 0.07790 0.039700 0.067100 4.79e-01 2.31e-01
NOD1 2 SIGNALING PATHWAY 35 7.44e-01 8.32e-01 0.07770 0.055900 0.054000 5.67e-01 5.80e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 8.81e-01 9.26e-01 0.07770 0.077600 0.004370 6.15e-01 9.77e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 281 8.40e-02 2.00e-01 0.07760 0.007340 0.077300 8.33e-01 2.61e-02
NUCLEAR ENVELOPE BREAKDOWN 47 6.73e-01 7.71e-01 0.07750 -0.046800 -0.061800 5.79e-01 4.64e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 5.24e-01 6.65e-01 0.07700 0.074800 0.018300 2.63e-01 7.84e-01
NEUREXINS AND NEUROLIGINS 54 6.01e-01 7.22e-01 0.07690 0.039400 -0.066100 6.17e-01 4.01e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 8.52e-01 9.07e-01 0.07670 -0.002670 0.076700 9.84e-01 5.73e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 8.52e-01 9.07e-01 0.07570 0.014200 0.074400 9.14e-01 5.75e-01
CELL CYCLE MITOTIC 470 2.23e-02 7.99e-02 0.07530 0.013800 0.074000 6.08e-01 6.15e-03
MITOTIC PROMETAPHASE 175 2.17e-01 3.93e-01 0.07520 0.072500 -0.019700 9.82e-02 6.54e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 8.78e-01 9.25e-01 0.07510 0.074500 -0.009970 6.18e-01 9.47e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 176 2.48e-01 4.22e-01 0.07480 0.068700 0.029700 1.16e-01 4.97e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 9.02e-01 9.37e-01 0.07480 -0.037200 -0.065000 8.17e-01 6.85e-01
DAG AND IP3 SIGNALING 40 7.19e-01 8.13e-01 0.07460 -0.074100 -0.008290 4.17e-01 9.28e-01
VLDLR INTERNALISATION AND DEGRADATION 12 9.00e-01 9.36e-01 0.07370 -0.054200 0.050000 7.45e-01 7.64e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 8.32e-01 8.98e-01 0.07310 -0.020200 0.070300 8.70e-01 5.68e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 6.61e-01 7.62e-01 0.07300 -0.036400 -0.063300 6.41e-01 4.17e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 9.11e-01 9.43e-01 0.07280 -0.058700 0.043200 7.36e-01 8.04e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 8.46e-01 9.03e-01 0.07210 -0.047400 0.054300 7.14e-01 6.74e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 141 3.13e-01 4.84e-01 0.07200 -0.040400 0.059600 4.08e-01 2.22e-01
OTHER INTERLEUKIN SIGNALING 20 8.65e-01 9.14e-01 0.07120 0.065900 0.027000 6.10e-01 8.35e-01
NEURONAL SYSTEM 363 6.83e-02 1.75e-01 0.07110 -0.071000 -0.003710 2.05e-02 9.04e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 7.85e-01 8.62e-01 0.07100 -0.016000 0.069200 8.77e-01 5.05e-01
VIRAL MESSENGER RNA SYNTHESIS 42 7.34e-01 8.25e-01 0.07090 -0.011800 -0.069900 8.94e-01 4.34e-01
CELLULAR SENESCENCE 140 3.42e-01 5.16e-01 0.07090 0.010700 -0.070000 8.27e-01 1.53e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 117 3.92e-01 5.52e-01 0.07080 0.057000 -0.042000 2.87e-01 4.33e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 5.57e-01 6.92e-01 0.07060 -0.015600 0.068900 8.15e-01 3.00e-01
RHO GTPASE CYCLE 427 5.32e-02 1.50e-01 0.07060 0.060700 0.036000 3.20e-02 2.03e-01
G1 S SPECIFIC TRANSCRIPTION 26 8.16e-01 8.84e-01 0.07050 -0.066300 0.024200 5.59e-01 8.31e-01
HOMOLOGY DIRECTED REPAIR 107 4.76e-01 6.30e-01 0.07050 -0.054800 -0.044300 3.27e-01 4.28e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 8.45e-01 9.03e-01 0.07020 0.017700 -0.068000 8.85e-01 5.81e-01
HCMV INFECTION 102 4.61e-01 6.17e-01 0.07000 0.067600 -0.018200 2.39e-01 7.51e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 8.55e-01 9.09e-01 0.06950 0.059100 0.036600 6.24e-01 7.61e-01
ION TRANSPORT BY P TYPE ATPASES 47 7.20e-01 8.13e-01 0.06940 -0.017000 -0.067200 8.40e-01 4.25e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 8.99e-01 9.36e-01 0.06930 -0.064800 0.024600 6.75e-01 8.73e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 9.05e-01 9.38e-01 0.06900 -0.047700 -0.049800 7.49e-01 7.38e-01
MAP2K AND MAPK ACTIVATION 36 7.85e-01 8.62e-01 0.06880 0.030600 0.061600 7.50e-01 5.22e-01
RAC3 GTPASE CYCLE 88 5.24e-01 6.65e-01 0.06870 -0.019000 0.066000 7.58e-01 2.85e-01
SIGNALING BY NOTCH 188 2.90e-01 4.70e-01 0.06870 0.038200 0.057100 3.67e-01 1.78e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 100 5.14e-01 6.62e-01 0.06840 0.027700 0.062600 6.33e-01 2.80e-01
CELLULAR RESPONSE TO HEAT STRESS 95 5.35e-01 6.70e-01 0.06830 0.030800 0.060900 6.05e-01 3.05e-01
REPRODUCTION 75 5.75e-01 7.05e-01 0.06790 0.040600 -0.054400 5.44e-01 4.15e-01
ION HOMEOSTASIS 48 7.17e-01 8.11e-01 0.06740 -0.067200 0.006060 4.21e-01 9.42e-01
RHOF GTPASE CYCLE 40 7.53e-01 8.38e-01 0.06680 -0.032200 0.058500 7.25e-01 5.22e-01
SIGNALING BY NOTCH1 75 5.87e-01 7.11e-01 0.06660 0.040300 -0.053100 5.46e-01 4.27e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 183 2.82e-01 4.59e-01 0.06620 -0.033600 0.057000 4.34e-01 1.84e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 9.13e-01 9.44e-01 0.06610 0.065900 0.005110 6.70e-01 9.74e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 7.01e-01 7.96e-01 0.06530 -0.065100 -0.004190 3.99e-01 9.57e-01
G ALPHA S SIGNALLING EVENTS 103 5.00e-01 6.52e-01 0.06500 -0.034800 0.055000 5.42e-01 3.36e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 7.66e-01 8.48e-01 0.06470 -0.029200 -0.057700 7.35e-01 5.03e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 9.27e-01 9.51e-01 0.06440 0.039500 0.050900 8.05e-01 7.51e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 8.38e-01 9.00e-01 0.06440 -0.064300 0.003880 5.56e-01 9.72e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.54e-01 6.10e-01 0.06440 -0.033800 -0.054800 4.96e-01 2.71e-01
ION CHANNEL TRANSPORT 138 4.48e-01 6.05e-01 0.06420 -0.029400 -0.057100 5.51e-01 2.47e-01
METABOLISM OF STEROID HORMONES 20 8.86e-01 9.28e-01 0.06410 0.008480 0.063500 9.48e-01 6.23e-01
PI METABOLISM 79 6.16e-01 7.32e-01 0.06370 -0.063700 0.002900 3.28e-01 9.64e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 8.68e-01 9.17e-01 0.06360 0.003840 -0.063500 9.75e-01 5.98e-01
MHC CLASS II ANTIGEN PRESENTATION 103 5.46e-01 6.82e-01 0.06340 0.011300 0.062400 8.43e-01 2.74e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 8.45e-01 9.03e-01 0.06340 0.050200 -0.038700 6.58e-01 7.33e-01
CIRCADIAN CLOCK 68 6.53e-01 7.57e-01 0.06300 -0.024700 0.058000 7.25e-01 4.08e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 8.48e-01 9.04e-01 0.06270 0.059700 0.019000 5.78e-01 8.59e-01
NONHOMOLOGOUS END JOINING NHEJ 43 7.91e-01 8.66e-01 0.06200 -0.055600 -0.027400 5.28e-01 7.56e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 9.47e-01 9.66e-01 0.06200 0.033200 0.052400 8.56e-01 7.74e-01
RET SIGNALING 37 8.07e-01 8.77e-01 0.06200 -0.000182 0.062000 9.98e-01 5.14e-01
ONCOGENE INDUCED SENESCENCE 32 8.41e-01 9.01e-01 0.06100 -0.015100 -0.059100 8.83e-01 5.63e-01
REGULATION OF BETA CELL DEVELOPMENT 24 8.81e-01 9.26e-01 0.06090 -0.029200 -0.053500 8.05e-01 6.50e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 8.62e-01 9.13e-01 0.06090 0.011000 -0.059900 9.23e-01 5.97e-01
TRNA PROCESSING IN THE NUCLEUS 56 7.37e-01 8.27e-01 0.06060 -0.005900 -0.060300 9.39e-01 4.35e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 6.98e-01 7.93e-01 0.06060 -0.016500 0.058300 8.21e-01 4.24e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 8.43e-01 9.02e-01 0.05900 -0.035100 -0.047400 7.20e-01 6.27e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 9.12e-01 9.43e-01 0.05890 -0.045100 -0.037900 7.34e-01 7.75e-01
CHROMOSOME MAINTENANCE 103 6.05e-01 7.26e-01 0.05890 0.029800 0.050700 6.01e-01 3.74e-01
SENSORY PERCEPTION 140 5.23e-01 6.65e-01 0.05750 0.031100 0.048400 5.26e-01 3.24e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 6.40e-01 7.49e-01 0.05750 -0.000351 0.057500 9.95e-01 3.46e-01
HIV TRANSCRIPTION ELONGATION 42 8.15e-01 8.84e-01 0.05720 0.057100 0.003500 5.22e-01 9.69e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 82 7.02e-01 7.96e-01 0.05550 -0.045200 -0.032200 4.79e-01 6.14e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 8.62e-01 9.13e-01 0.05540 -0.050700 -0.022300 6.09e-01 8.22e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 8.97e-01 9.36e-01 0.05480 0.051600 -0.018500 6.68e-01 8.78e-01
PRC2 METHYLATES HISTONES AND DNA 29 8.83e-01 9.26e-01 0.05280 0.052100 -0.008320 6.27e-01 9.38e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 8.79e-01 9.25e-01 0.05250 0.023800 0.046800 8.13e-01 6.42e-01
DEATH RECEPTOR SIGNALLING 134 5.70e-01 7.02e-01 0.05230 0.051200 -0.010500 3.07e-01 8.34e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 9.18e-01 9.45e-01 0.05090 -0.048000 0.016800 7.03e-01 8.94e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 9.31e-01 9.53e-01 0.05080 0.049700 -0.010700 7.15e-01 9.37e-01
VXPX CARGO TARGETING TO CILIUM 19 9.29e-01 9.53e-01 0.05060 0.050600 -0.001230 7.03e-01 9.93e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 8.27e-01 8.94e-01 0.04970 0.030800 -0.038900 7.12e-01 6.41e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 8.91e-01 9.32e-01 0.04920 -0.033600 -0.036000 7.35e-01 7.17e-01
L1CAM INTERACTIONS 109 6.79e-01 7.76e-01 0.04910 0.048800 0.005950 3.80e-01 9.15e-01
CELL CYCLE 588 1.34e-01 2.78e-01 0.04900 0.006180 0.048600 7.99e-01 4.52e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 9.24e-01 9.50e-01 0.04860 0.023600 -0.042500 8.51e-01 7.36e-01
SIGNALING BY NOTCH3 48 8.39e-01 9.00e-01 0.04850 0.013200 -0.046700 8.74e-01 5.76e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 51 8.25e-01 8.93e-01 0.04850 -0.037100 0.031200 6.47e-01 7.00e-01
SUMOYLATION 162 5.80e-01 7.07e-01 0.04840 -0.046400 -0.013800 3.09e-01 7.62e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 9.36e-01 9.58e-01 0.04810 0.048000 -0.003070 7.17e-01 9.82e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 9.00e-01 9.36e-01 0.04800 -0.047800 0.004100 6.50e-01 9.69e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 184 5.17e-01 6.63e-01 0.04800 -0.016800 0.044900 6.95e-01 2.94e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 7.68e-01 8.50e-01 0.04760 0.019200 -0.043500 7.75e-01 5.18e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 27 9.18e-01 9.45e-01 0.04560 0.005880 -0.045200 9.58e-01 6.84e-01
REGULATION OF TP53 ACTIVITY 148 6.18e-01 7.32e-01 0.04510 0.031000 -0.032800 5.16e-01 4.92e-01
DISEASES OF GLYCOSYLATION 124 6.70e-01 7.68e-01 0.04500 0.024400 -0.037800 6.39e-01 4.67e-01
DNA METHYLATION 20 9.38e-01 9.58e-01 0.04470 0.036600 -0.025700 7.77e-01 8.42e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 7.75e-01 8.55e-01 0.04430 -0.000542 -0.044300 9.93e-01 4.76e-01
RNA POLYMERASE II TRANSCRIPTION 1083 5.14e-02 1.48e-01 0.04370 -0.043400 0.005640 1.69e-02 7.56e-01
EXTENSION OF TELOMERES 50 8.59e-01 9.12e-01 0.04370 0.038200 -0.021300 6.41e-01 7.95e-01
HCMV LATE EVENTS 64 8.28e-01 8.94e-01 0.04350 -0.041400 0.013300 5.67e-01 8.55e-01
GLYCOLYSIS 66 8.35e-01 8.99e-01 0.04300 0.004120 0.042800 9.54e-01 5.48e-01
PD 1 SIGNALING 10 9.72e-01 9.83e-01 0.04270 0.042100 -0.007350 8.18e-01 9.68e-01
ACYL CHAIN REMODELLING OF PC 17 9.59e-01 9.76e-01 0.04200 0.028900 0.030500 8.36e-01 8.28e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 8.99e-01 9.36e-01 0.04110 0.000586 -0.041100 9.95e-01 6.45e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 9.67e-01 9.81e-01 0.04010 -0.033400 0.022100 8.35e-01 8.90e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 9.17e-01 9.45e-01 0.04000 -0.007650 0.039200 9.38e-01 6.88e-01
PHOSPHOLIPID METABOLISM 185 6.42e-01 7.49e-01 0.03990 -0.002800 0.039800 9.48e-01 3.51e-01
MRNA CAPPING 29 9.37e-01 9.58e-01 0.03970 0.015200 0.036700 8.88e-01 7.32e-01
MEIOSIS 63 8.77e-01 9.25e-01 0.03810 -0.013300 -0.035700 8.55e-01 6.25e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 8.92e-01 9.32e-01 0.03650 -0.017000 -0.032200 8.18e-01 6.63e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 9.48e-01 9.66e-01 0.03580 -0.030800 0.018300 7.86e-01 8.72e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 9.16e-01 9.45e-01 0.03470 -0.028700 -0.019500 7.21e-01 8.08e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 9.18e-01 9.45e-01 0.03380 0.012200 0.031600 8.79e-01 6.94e-01
HYALURONAN METABOLISM 15 9.76e-01 9.86e-01 0.03200 -0.030400 0.009940 8.38e-01 9.47e-01
GOLGI TO ER RETROGRADE TRANSPORT 118 8.38e-01 9.00e-01 0.03110 -0.007750 0.030100 8.85e-01 5.73e-01
INTERLEUKIN 6 SIGNALING 10 9.89e-01 9.93e-01 0.02860 -0.017800 -0.022400 9.22e-01 9.03e-01
METABOLISM OF FAT SOLUBLE VITAMINS 31 9.63e-01 9.79e-01 0.02860 0.002920 0.028400 9.78e-01 7.84e-01
ONCOGENIC MAPK SIGNALING 77 9.25e-01 9.50e-01 0.02580 -0.003470 0.025500 9.58e-01 6.99e-01
RHOD GTPASE CYCLE 50 9.55e-01 9.72e-01 0.02570 0.015000 0.020800 8.54e-01 7.99e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 9.66e-01 9.80e-01 0.02340 0.003990 0.023100 9.64e-01 7.93e-01
TELOMERE MAINTENANCE 79 9.41e-01 9.61e-01 0.02330 0.009970 0.021000 8.78e-01 7.47e-01
P38MAPK EVENTS 13 9.89e-01 9.93e-01 0.02320 0.015300 -0.017400 9.24e-01 9.13e-01
G0 AND EARLY G1 24 9.80e-01 9.89e-01 0.02280 -0.015200 0.017000 8.97e-01 8.85e-01
MISMATCH REPAIR 14 9.90e-01 9.93e-01 0.02170 0.021700 0.000320 8.88e-01 9.98e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 9.93e-01 9.94e-01 0.02000 -0.014100 -0.014200 9.30e-01 9.29e-01
MUSCLE CONTRACTION 162 9.04e-01 9.38e-01 0.01970 0.015100 -0.012700 7.41e-01 7.80e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 9.69e-01 9.82e-01 0.01940 -0.015500 -0.011700 8.36e-01 8.76e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 85 9.63e-01 9.79e-01 0.01770 -0.010700 -0.014100 8.65e-01 8.22e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 35 9.87e-01 9.93e-01 0.01640 0.010700 0.012500 9.13e-01 8.98e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 9.71e-01 9.83e-01 0.01630 0.014800 0.006610 8.22e-01 9.20e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 9.91e-01 9.93e-01 0.01520 0.001670 -0.015100 9.88e-01 8.94e-01
SNRNP ASSEMBLY 51 9.83e-01 9.91e-01 0.01510 -0.004380 -0.014400 9.57e-01 8.59e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 9.91e-01 9.93e-01 0.01170 0.002700 -0.011300 9.76e-01 8.99e-01
ESTROGEN DEPENDENT GENE EXPRESSION 100 9.87e-01 9.93e-01 0.00923 -0.009210 -0.000595 8.74e-01 9.92e-01
TRANSCRIPTIONAL REGULATION BY TP53 338 9.76e-01 9.86e-01 0.00680 -0.004060 0.005460 8.98e-01 8.64e-01
FLT3 SIGNALING IN DISEASE 27 1.00e+00 1.00e+00 0.00117 -0.000334 0.001120 9.98e-01 9.92e-01



Detailed Gene set reports


EUKARYOTIC TRANSLATION ELONGATION
EUKARYOTIC TRANSLATION ELONGATION
metric value
setSize 87
pMANOVA 3.47e-25
p.adjustMANOVA 1.01e-22
s.dist 0.68
s.LPS 0.443
s.OVA 0.516
p.LPS 9.1e-13
p.OVA 9.08e-17



Top 20 genes
Gene LPS OVA
Rps8 7270 7311
Rpl23a 6018 7527
Rps9 5472 7585
Eef1a2 6137 6746
Rps29 6456 5766
Rps4x 5415 6684
Rps27a 5724 6255
Rpl23 5510 6488
Rpl6 5267 6717
Rps27l 4687 7436
Eef1g 4577 7434
Rpl37a 5426 6158
Rps25 4266 7815
Rpl24 4399 7498
Eef2 6021 5222
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303

Click HERE to show all gene set members

All member genes
LPS OVA
Eef1a1 -2827 7025
Eef1a2 6137 6746
Eef1b2 2757 5403
Eef1d 6663 3425
Eef1g 4577 7434
Eef2 6021 5222
Fau 3643 5715
Rpl10 3682 -3710
Rpl10a 888 726
Rpl11 2279 5274
Rpl12 3716 -7461
Rpl13 3905 3221
Rpl13a 405 6092
Rpl14 3949 5504
Rpl15 -3304 3006
Rpl17 -2676 5572
Rpl18 1840 261
Rpl18a 3852 5324
Rpl19 2620 3552
Rpl21 2972 2665
Rpl22 728 5845
Rpl22l1 -3346 6909
Rpl23 5510 6488
Rpl23a 6018 7527
Rpl24 4399 7498
Rpl26 7185 3618
Rpl27 526 5183
Rpl27a 2841 2778
Rpl28 6953 831
Rpl29 -308 3647
Rpl3 2606 5904
Rpl30 3373 5170
Rpl31 3209 5661
Rpl32 3943 4605
Rpl34 -368 3499
Rpl35 6124 4244
Rpl35a 4655 5454
Rpl36 2401 -378
Rpl36a 920 4020
Rpl36al 2701 1803
Rpl37 5412 2940
Rpl37a 5426 6158
Rpl38 6480 3981
Rpl39 -2411 4849
Rpl4 867 6116
Rpl5 1280 6007
Rpl6 5267 6717
Rpl7 -1345 4993
Rpl7a 4403 2278
Rpl8 5074 2662
Rpl9 1475 5114
Rplp0 -305 5859
Rplp1 4411 -555
Rplp2 6466 773
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099
Uba52 3802 4658





TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
metric value
setSize 11
pMANOVA 0.00085
p.adjustMANOVA 0.0064
s.dist 0.659
s.LPS 0.0789
s.OVA 0.654
p.LPS 0.65
p.OVA 0.000173



Top 20 genes
Gene LPS OVA
Unc93b1 5058 5733
Ctsl 4755 5449
Ctsk 3971 4373
Tlr7 2250 7064
Hsp90b1 2501 6286
Lgmn 923 7881

Click HERE to show all gene set members

All member genes
LPS OVA
Cnpy3 -1460 1644
Ctsb -1704 7801
Ctsk 3971 4373
Ctsl 4755 5449
Ctss -1896 7907
Hsp90b1 2501 6286
Lgmn 923 7881
Tlr3 -7410 4632
Tlr7 2250 7064
Tlr9 -5006 -1431
Unc93b1 5058 5733





MET ACTIVATES RAP1 AND RAC1
MET ACTIVATES RAP1 AND RAC1
metric value
setSize 11
pMANOVA 0.00129
p.adjustMANOVA 0.0088
s.dist 0.618
s.LPS -0.568
s.OVA 0.245
p.LPS 0.00111
p.OVA 0.16



Top 20 genes
Gene LPS OVA
Rap1b -8318 6949
Rac1 -7037 7671
Gab1 -4807 7455
Rap1a -5208 6755
Crk -5151 6485
Crkl -5468 4718
Grb2 -3206 1149

Click HERE to show all gene set members

All member genes
LPS OVA
Crk -5151 6485
Crkl -5468 4718
Dock7 -6767 -8138
Gab1 -4807 7455
Grb2 -3206 1149
Hgf -7725 -5023
Met -7731 -4407
Rac1 -7037 7671
Rap1a -5208 6755
Rap1b -8318 6949
Rapgef1 4588 -3485





COMPLEX I BIOGENESIS
COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 1.24e-13
p.adjustMANOVA 7.24e-12
s.dist 0.612
s.LPS 0.295
s.OVA 0.536
p.LPS 0.000133
p.OVA 3.84e-12



Top 20 genes
Gene LPS OVA
Timmdc1 7358 7321
Ndufa12 7000 7524
Ndufa10 5718 7440
Ndufaf1 5656 7102
Ndufa13 6594 5814
Ndufs2 4509 7475
Ndufaf2 4875 6156
Ndufaf6 4273 6562
Ndufs5 5917 4691
Ndufa6 5354 4750
Tmem126b 7103 3220
Ndufs6 5838 3822
Ndufb8 3173 6155
Ndufv1 5330 3458
Ndufs4 2428 7476
Ndufb5 2198 7900
Ndufb3 6623 2487
Ndufb9 2240 6716
Ndufa5 1898 7073
Ndufaf5 2351 5653

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 609 1982
Ecsit 1597 2337
mt-Nd1 -3441 7548
mt-Nd2 -4164 7400
mt-Nd3 -125 7653
mt-Nd4 -4486 7748
mt-Nd5 -4796 7473
mt-Nd6 -5973 7649
Ndufa1 4456 2809
Ndufa10 5718 7440
Ndufa11 2654 -920
Ndufa12 7000 7524
Ndufa13 6594 5814
Ndufa2 3299 -1358
Ndufa3 5067 -187
Ndufa5 1898 7073
Ndufa6 5354 4750
Ndufa7 1188 4513
Ndufa8 3955 1692
Ndufa9 214 -1151
Ndufab1 1655 5590
Ndufaf1 5656 7102
Ndufaf2 4875 6156
Ndufaf3 -710 -1141
Ndufaf4 -86 7831
Ndufaf5 2351 5653
Ndufaf6 4273 6562
Ndufaf7 953 -1197
Ndufb1 -3381 3410
Ndufb10 7581 314
Ndufb11 56 6444
Ndufb2 5314 1230
Ndufb3 6623 2487
Ndufb4 -1780 6524
Ndufb5 2198 7900
Ndufb6 2317 4164
Ndufb7 4406 1364
Ndufb8 3173 6155
Ndufb9 2240 6716
Ndufc1 575 7835
Ndufc2 -860 4793
Ndufs1 -1827 6348
Ndufs2 4509 7475
Ndufs3 -2765 5969
Ndufs4 2428 7476
Ndufs5 5917 4691
Ndufs6 5838 3822
Ndufs7 4331 2097
Ndufs8 2348 349
Ndufv1 5330 3458
Ndufv2 -2934 7853
Ndufv3 1928 201
Nubpl -4048 24
Timmdc1 7358 7321
Tmem126b 7103 3220
Tmem186 333 -7230





RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
metric value
setSize 94
pMANOVA 1.61e-21
p.adjustMANOVA 2.09e-19
s.dist 0.603
s.LPS 0.38
s.OVA 0.468
p.LPS 1.91e-10
p.OVA 4.28e-15



Top 20 genes
Gene LPS OVA
Rps8 7270 7311
Rpl23a 6018 7527
Rps9 5472 7585
Rps29 6456 5766
Rps4x 5415 6684
Rps27a 5724 6255
Rpl23 5510 6488
Rpl6 5267 6717
Rps27l 4687 7436
Rpl37a 5426 6158
Rps25 4266 7815
Rpl24 4399 7498
Ddit3 7455 4241
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303
Rpl26 7185 3618
Rpl35 6124 4244

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -6225 7463
Atf2 -8293 1693
Atf3 2585 -1128
Atf4 3753 -2100
Cebpb -4193 4496
Cebpg -1729 647
Ddit3 7455 4241
Eif2ak4 834 -8346
Eif2s1 -1078 7336
Eif2s2 -1382 7344
Eif2s3x -1912 7280
Fau 3643 5715
Gcn1 6036 -7703
Impact 872 5524
Rpl10 3682 -3710
Rpl10a 888 726
Rpl11 2279 5274
Rpl12 3716 -7461
Rpl13 3905 3221
Rpl13a 405 6092
Rpl14 3949 5504
Rpl15 -3304 3006
Rpl17 -2676 5572
Rpl18 1840 261
Rpl18a 3852 5324
Rpl19 2620 3552
Rpl21 2972 2665
Rpl22 728 5845
Rpl22l1 -3346 6909
Rpl23 5510 6488
Rpl23a 6018 7527
Rpl24 4399 7498
Rpl26 7185 3618
Rpl27 526 5183
Rpl27a 2841 2778
Rpl28 6953 831
Rpl29 -308 3647
Rpl3 2606 5904
Rpl30 3373 5170
Rpl31 3209 5661
Rpl32 3943 4605
Rpl34 -368 3499
Rpl35 6124 4244
Rpl35a 4655 5454
Rpl36 2401 -378
Rpl36a 920 4020
Rpl36al 2701 1803
Rpl37 5412 2940
Rpl37a 5426 6158
Rpl38 6480 3981
Rpl39 -2411 4849
Rpl4 867 6116
Rpl5 1280 6007
Rpl6 5267 6717
Rpl7 -1345 4993
Rpl7a 4403 2278
Rpl8 5074 2662
Rpl9 1475 5114
Rplp0 -305 5859
Rplp1 4411 -555
Rplp2 6466 773
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099
Uba52 3802 4658





ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
metric value
setSize 12
pMANOVA 0.00227
p.adjustMANOVA 0.0142
s.dist 0.601
s.LPS 0.372
s.OVA 0.472
p.LPS 0.0256
p.OVA 0.00464



Top 20 genes
Gene LPS OVA
Elovl1 7795 8073
Hsd17b4 4860 7356
Fads2 4720 4715
Fads1 5081 4256
Scp2 1588 7595
Elovl5 403 7731

Click HERE to show all gene set members

All member genes
LPS OVA
Abcd1 5580 -2470
Acaa1a 5946 -6783
Acot8 5674 -1053
Acox1 -5297 5266
Acsl1 -4201 4261
Elovl1 7795 8073
Elovl2 -895 5556
Elovl5 403 7731
Fads1 5081 4256
Fads2 4720 4715
Hsd17b4 4860 7356
Scp2 1588 7595





SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
metric value
setSize 106
pMANOVA 3.75e-23
p.adjustMANOVA 6.25e-21
s.dist 0.589
s.LPS 0.324
s.OVA 0.491
p.LPS 8.02e-09
p.OVA 2.32e-18



Top 20 genes
Gene LPS OVA
Rps8 7270 7311
Rpl23a 6018 7527
Rps9 5472 7585
Rps29 6456 5766
Srp72 5012 7223
Rps4x 5415 6684
Rps27a 5724 6255
Rpl23 5510 6488
Rpl6 5267 6717
Rps27l 4687 7436
Rpl37a 5426 6158
Rps25 4266 7815
Rpl24 4399 7498
Srpr 4717 6547
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303
Sec11c 4098 6780

Click HERE to show all gene set members

All member genes
LPS OVA
Ddost -1462 6073
Fau 3643 5715
Rpl10 3682 -3710
Rpl10a 888 726
Rpl11 2279 5274
Rpl12 3716 -7461
Rpl13 3905 3221
Rpl13a 405 6092
Rpl14 3949 5504
Rpl15 -3304 3006
Rpl17 -2676 5572
Rpl18 1840 261
Rpl18a 3852 5324
Rpl19 2620 3552
Rpl21 2972 2665
Rpl22 728 5845
Rpl22l1 -3346 6909
Rpl23 5510 6488
Rpl23a 6018 7527
Rpl24 4399 7498
Rpl26 7185 3618
Rpl27 526 5183
Rpl27a 2841 2778
Rpl28 6953 831
Rpl29 -308 3647
Rpl3 2606 5904
Rpl30 3373 5170
Rpl31 3209 5661
Rpl32 3943 4605
Rpl34 -368 3499
Rpl35 6124 4244
Rpl35a 4655 5454
Rpl36 2401 -378
Rpl36a 920 4020
Rpl36al 2701 1803
Rpl37 5412 2940
Rpl37a 5426 6158
Rpl38 6480 3981
Rpl39 -2411 4849
Rpl4 867 6116
Rpl5 1280 6007
Rpl6 5267 6717
Rpl7 -1345 4993
Rpl7a 4403 2278
Rpl8 5074 2662
Rpl9 1475 5114
Rplp0 -305 5859
Rplp1 4411 -555
Rplp2 6466 773
Rpn1 -4163 2584
Rpn2 1734 3256
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099
Sec11a 3184 817
Sec11c 4098 6780
Sec61a1 -2396 -5457
Sec61a2 1709 -6145
Sec61b 1067 2090
Sec61g -4236 3215
Spcs1 760 7923
Spcs2 -1136 5443
Spcs3 -7045 6008
Srp14 939 3819
Srp19 3297 4095
Srp54a -5653 7018
Srp68 969 -975
Srp72 5012 7223
Srp9 -3094 5617
Srpr 4717 6547
Srprb 3732 5430
Ssr1 -5628 5008
Ssr2 -2632 4035
Ssr3 -5722 7547
Ssr4 -186 -81
Tram1 -8098 2525
Uba52 3802 4658





ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
metric value
setSize 19
pMANOVA 3.06e-05
p.adjustMANOVA 0.000425
s.dist 0.589
s.LPS -0.222
s.OVA 0.545
p.LPS 0.0934
p.OVA 3.92e-05



Top 20 genes
Gene LPS OVA
P2ry12 -6747 7373
Gng12 -6343 7763
Gnai1 -8727 5038
Gng10 -5608 7086
Gnai3 -5036 6995
Gnb4 -8083 2629
Gng2 -8001 1552
Gng5 -818 7008
Gnai2 -1157 4085
Gnb1 -6679 593
Gng13 -3690 919
Gng11 -360 6593
Gng7 -405 5103
Gnb2 -173 1359

Click HERE to show all gene set members

All member genes
LPS OVA
Gnai1 -8727 5038
Gnai2 -1157 4085
Gnai3 -5036 6995
Gnb1 -6679 593
Gnb2 -173 1359
Gnb4 -8083 2629
Gnb5 2323 6657
Gng10 -5608 7086
Gng11 -360 6593
Gng12 -6343 7763
Gng13 -3690 919
Gng2 -8001 1552
Gng3 4650 4213
Gng4 689 2011
Gng5 -818 7008
Gng7 -405 5103
Gng8 5765 2069
Gngt2 4502 2829
P2ry12 -6747 7373





INITIAL TRIGGERING OF COMPLEMENT
INITIAL TRIGGERING OF COMPLEMENT
metric value
setSize 10
pMANOVA 0.0085
p.adjustMANOVA 0.0395
s.dist 0.582
s.LPS 0.474
s.OVA 0.337
p.LPS 0.0094
p.OVA 0.0648



Top 20 genes
Gene LPS OVA
C1qb 6801 7124
C2 7641 5522
C1qc 4298 7484
C1qa 2949 7432
Masp1 2775 7046
C4b 4807 3713

Click HERE to show all gene set members

All member genes
LPS OVA
C1qa 2949 7432
C1qb 6801 7124
C1qc 4298 7484
C2 7641 5522
C4b 4807 3713
Cfb -7655 -6025
Cfp 7564 -1864
Gzmm -541 -2229
Masp1 2775 7046
Masp2 5861 -2260





CD28 DEPENDENT VAV1 PATHWAY
CD28 DEPENDENT VAV1 PATHWAY
metric value
setSize 10
pMANOVA 0.00456
p.adjustMANOVA 0.0244
s.dist 0.578
s.LPS -0.409
s.OVA 0.409
p.LPS 0.025
p.OVA 0.0253



Top 20 genes
Gene LPS OVA
Rac1 -7037 7671
Cdc42 -6735 6328
Pak1 -7208 4466
Cd86 -6900 4267
Pak2 -2251 7895
Pak3 -3656 4266
Grb2 -3206 1149
Fyn -3968 235

Click HERE to show all gene set members

All member genes
LPS OVA
Cd86 -6900 4267
Cdc42 -6735 6328
Fyn -3968 235
Grb2 -3206 1149
Lck -5197 -4238
Pak1 -7208 4466
Pak2 -2251 7895
Pak3 -3656 4266
Rac1 -7037 7671
Vav1 7575 -197





EUKARYOTIC TRANSLATION INITIATION
EUKARYOTIC TRANSLATION INITIATION
metric value
setSize 114
pMANOVA 6.19e-23
p.adjustMANOVA 9.02e-21
s.dist 0.565
s.LPS 0.306
s.OVA 0.475
p.LPS 1.73e-08
p.OVA 1.93e-18



Top 20 genes
Gene LPS OVA
Rps8 7270 7311
Rpl23a 6018 7527
Rps9 5472 7585
Eif5b 7140 5418
Rps29 6456 5766
Rps4x 5415 6684
Rps27a 5724 6255
Rpl23 5510 6488
Rpl6 5267 6717
Rps27l 4687 7436
Rpl37a 5426 6158
Rps25 4266 7815
Rpl24 4399 7498
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303
Rpl26 7185 3618
Rpl35 6124 4244

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7594 3727
Eif2b1 -7905 -2149
Eif2b2 4324 4486
Eif2b3 -6510 -1339
Eif2b4 6275 2992
Eif2b5 2117 3311
Eif2s1 -1078 7336
Eif2s2 -1382 7344
Eif2s3x -1912 7280
Eif3a 7515 -4664
Eif3b 3393 1727
Eif3c 2561 2727
Eif3d 384 142
Eif3e -7886 6873
Eif3f 2087 5719
Eif3g 3251 4181
Eif3h 2548 5342
Eif3i 2098 2269
Eif3j1 2130 346
Eif3j2 -2618 7285
Eif3k -2272 -1119
Eif3l -593 3718
Eif3m -7077 6798
Eif4a1 -1989 2218
Eif4a2 -7549 5784
Eif4b -1894 4202
Eif4e -4691 6658
Eif4ebp1 1854 3170
Eif4g1 5629 -6391
Eif4h -2505 -1074
Eif5 -7016 4892
Eif5b 7140 5418
Fau 3643 5715
Pabpc1 -1115 6439
Rpl10 3682 -3710
Rpl10a 888 726
Rpl11 2279 5274
Rpl12 3716 -7461
Rpl13 3905 3221
Rpl13a 405 6092
Rpl14 3949 5504
Rpl15 -3304 3006
Rpl17 -2676 5572
Rpl18 1840 261
Rpl18a 3852 5324
Rpl19 2620 3552
Rpl21 2972 2665
Rpl22 728 5845
Rpl22l1 -3346 6909
Rpl23 5510 6488
Rpl23a 6018 7527
Rpl24 4399 7498
Rpl26 7185 3618
Rpl27 526 5183
Rpl27a 2841 2778
Rpl28 6953 831
Rpl29 -308 3647
Rpl3 2606 5904
Rpl30 3373 5170
Rpl31 3209 5661
Rpl32 3943 4605
Rpl34 -368 3499
Rpl35 6124 4244
Rpl35a 4655 5454
Rpl36 2401 -378
Rpl36a 920 4020
Rpl36al 2701 1803
Rpl37 5412 2940
Rpl37a 5426 6158
Rpl38 6480 3981
Rpl39 -2411 4849
Rpl4 867 6116
Rpl5 1280 6007
Rpl6 5267 6717
Rpl7 -1345 4993
Rpl7a 4403 2278
Rpl8 5074 2662
Rpl9 1475 5114
Rplp0 -305 5859
Rplp1 4411 -555
Rplp2 6466 773
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099
Uba52 3802 4658





NUCLEOTIDE LIKE PURINERGIC RECEPTORS
NUCLEOTIDE LIKE PURINERGIC RECEPTORS
metric value
setSize 13
pMANOVA 0.00243
p.adjustMANOVA 0.0149
s.dist 0.557
s.LPS 0.0356
s.OVA 0.556
p.LPS 0.824
p.OVA 0.000521



Top 20 genes
Gene LPS OVA
Adora3 6379 7067
Gpr17 7439 5818
P2ry1 4896 7337
Adora2b 4073 5006
P2ry13 1705 5877
Lpar6 2150 568

Click HERE to show all gene set members

All member genes
LPS OVA
Adora1 -3798 929
Adora2a -426 4687
Adora2b 4073 5006
Adora3 6379 7067
Gpr17 7439 5818
Lpar4 -7643 2282
Lpar6 2150 568
P2ry1 4896 7337
P2ry12 -6747 7373
P2ry13 1705 5877
P2ry14 -794 7053
P2ry2 -6592 -494
P2ry6 -2963 3703





PINK1 PRKN MEDIATED MITOPHAGY
PINK1 PRKN MEDIATED MITOPHAGY
metric value
setSize 22
pMANOVA 6.1e-05
p.adjustMANOVA 0.000733
s.dist 0.554
s.LPS 0.188
s.OVA 0.521
p.LPS 0.127
p.OVA 2.34e-05



Top 20 genes
Gene LPS OVA
Rps27a 5724 6255
Prkn 7376 4059
Map1lc3a 5525 4271
Tomm6 3227 6852
Uba52 3802 4658
Map1lc3b 2144 5938
Ubb 2567 4441
Vdac1 1586 5839
Tomm7 2624 2389
Mterf3 1372 4079
Sqstm1 723 5404
Tomm40 3704 1046
Tomm5 1861 1985

Click HERE to show all gene set members

All member genes
LPS OVA
Atg12 -4516 4909
Atg5 -3862 6428
Map1lc3a 5525 4271
Map1lc3b 2144 5938
Mfn1 5452 -1471
Mfn2 4723 -564
Mterf3 1372 4079
Pink1 -1900 5580
Prkn 7376 4059
Rps27a 5724 6255
Sqstm1 723 5404
Tomm20 -7837 7655
Tomm22 -5401 5774
Tomm40 3704 1046
Tomm5 1861 1985
Tomm6 3227 6852
Tomm7 2624 2389
Tomm70a -8174 5558
Uba52 3802 4658
Ubb 2567 4441
Ubc 3035 -673
Vdac1 1586 5839





RESPIRATORY ELECTRON TRANSPORT
RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 102
pMANOVA 4.04e-20
p.adjustMANOVA 4.28e-18
s.dist 0.554
s.LPS 0.21
s.OVA 0.512
p.LPS 0.000246
p.OVA 3.84e-19



Top 20 genes
Gene LPS OVA
Timmdc1 7358 7321
Ndufa12 7000 7524
Ndufa10 5718 7440
Ndufaf1 5656 7102
Ndufa13 6594 5814
Ndufs2 4509 7475
Ndufaf2 4875 6156
Ndufaf6 4273 6562
Ndufs5 5917 4691
Sco2 4449 5971
Ndufa6 5354 4750
Taco1 5105 4949
Cox5b 4771 5260
Surf1 3346 6964
Tmem126b 7103 3220
Ndufs6 5838 3822
Cox5a 2968 7058
Coq10a 3816 5337
Ndufb8 3173 6155
Ndufv1 5330 3458

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 609 1982
Coq10a 3816 5337
Coq10b -3904 7973
Cox11 4945 -7061
Cox14 -791 -2269
Cox16 -5838 4704
Cox18 1919 4166
Cox19 6182 -4413
Cox20 494 5295
Cox4i1 2760 419
Cox5a 2968 7058
Cox5b 4771 5260
Cox6a1 533 6491
Cox6b1 3315 1740
Cox6c 1238 4894
Cox7a2l 1781 7723
Cox7b 367 4502
Cox7c 1268 5797
Cox8a 139 4536
Cyc1 1433 2317
Cycs -4451 7304
Ecsit 1597 2337
Etfa -2759 3111
Etfb -1009 1993
Etfdh -5077 1102
Lrpprc -4806 -6900
mt-Co1 -2713 7833
mt-Co2 -2572 7454
mt-Co3 -1213 7243
mt-Cytb -1701 7370
mt-Nd1 -3441 7548
mt-Nd2 -4164 7400
mt-Nd3 -125 7653
mt-Nd4 -4486 7748
mt-Nd5 -4796 7473
mt-Nd6 -5973 7649
Ndufa1 4456 2809
Ndufa10 5718 7440
Ndufa11 2654 -920
Ndufa12 7000 7524
Ndufa13 6594 5814
Ndufa2 3299 -1358
Ndufa3 5067 -187
Ndufa4 648 6890
Ndufa5 1898 7073
Ndufa6 5354 4750
Ndufa7 1188 4513
Ndufa8 3955 1692
Ndufa9 214 -1151
Ndufab1 1655 5590
Ndufaf1 5656 7102
Ndufaf2 4875 6156
Ndufaf3 -710 -1141
Ndufaf4 -86 7831
Ndufaf5 2351 5653
Ndufaf6 4273 6562
Ndufaf7 953 -1197
Ndufb1 -3381 3410
Ndufb10 7581 314
Ndufb11 56 6444
Ndufb2 5314 1230
Ndufb3 6623 2487
Ndufb4 -1780 6524
Ndufb5 2198 7900
Ndufb6 2317 4164
Ndufb7 4406 1364
Ndufb8 3173 6155
Ndufb9 2240 6716
Ndufc1 575 7835
Ndufc2 -860 4793
Ndufs1 -1827 6348
Ndufs2 4509 7475
Ndufs3 -2765 5969
Ndufs4 2428 7476
Ndufs5 5917 4691
Ndufs6 5838 3822
Ndufs7 4331 2097
Ndufs8 2348 349
Ndufv1 5330 3458
Ndufv2 -2934 7853
Ndufv3 1928 201
Nubpl -4048 24
Sco1 -8421 89
Sco2 4449 5971
Sdha -195 5193
Sdhb -706 4439
Sdhc 266 7697
Sdhd -1587 4982
Surf1 3346 6964
Taco1 5105 4949
Timmdc1 7358 7321
Tmem126b 7103 3220
Tmem186 333 -7230
Trap1 6958 -274
Uqcr10 2813 942
Uqcr11 2519 -883
Uqcrb 2531 7257
Uqcrc1 3153 823
Uqcrc2 -6455 5462
Uqcrfs1 -1373 3879
Uqcrh 1341 3289
Uqcrq 2766 4380





SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
metric value
setSize 12
pMANOVA 0.00572
p.adjustMANOVA 0.0282
s.dist 0.553
s.LPS 0.32
s.OVA 0.451
p.LPS 0.0552
p.OVA 0.0068



Top 20 genes
Gene LPS OVA
Ptgis 7582 6047
Rxra 5741 6257
Hsd17b4 4860 7356
Hsd3b7 4572 7470
Cyp27a1 5720 4416
Slc27a2 6195 2594
Scp2 1588 7595

Click HERE to show all gene set members

All member genes
LPS OVA
Acot8 5674 -1053
Amacr -5667 2233
Cyp27a1 5720 4416
Cyp7b1 -691 4706
Hsd17b4 4860 7356
Hsd3b7 4572 7470
Ncoa1 -5290 -2927
Ncoa2 -4239 -2253
Ptgis 7582 6047
Rxra 5741 6257
Scp2 1588 7595
Slc27a2 6195 2594





ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
metric value
setSize 59
pMANOVA 9.69e-12
p.adjustMANOVA 4.71e-10
s.dist 0.551
s.LPS 0.27
s.OVA 0.48
p.LPS 0.00033
p.OVA 1.73e-10



Top 20 genes
Gene LPS OVA
Rps8 7270 7311
Rps9 5472 7585
Rps29 6456 5766
Rps4x 5415 6684
Rps27a 5724 6255
Rps27l 4687 7436
Rps25 4266 7815
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303
Fau 3643 5715
Rps24 3023 6359
Rps21 5590 3174
Rps7 2682 6269
Eif3h 2548 5342
Eif3g 3251 4181
Rps11 3857 3503
Rps13 5834 2142

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7594 3727
Eif2s1 -1078 7336
Eif2s2 -1382 7344
Eif2s3x -1912 7280
Eif3a 7515 -4664
Eif3b 3393 1727
Eif3c 2561 2727
Eif3d 384 142
Eif3e -7886 6873
Eif3f 2087 5719
Eif3g 3251 4181
Eif3h 2548 5342
Eif3i 2098 2269
Eif3j1 2130 346
Eif3j2 -2618 7285
Eif3k -2272 -1119
Eif3l -593 3718
Eif3m -7077 6798
Eif4a1 -1989 2218
Eif4a2 -7549 5784
Eif4b -1894 4202
Eif4e -4691 6658
Eif4ebp1 1854 3170
Eif4g1 5629 -6391
Eif4h -2505 -1074
Fau 3643 5715
Pabpc1 -1115 6439
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099





CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
metric value
setSize 11
pMANOVA 0.00463
p.adjustMANOVA 0.0245
s.dist 0.551
s.LPS -0.432
s.OVA 0.342
p.LPS 0.013
p.OVA 0.0497



Top 20 genes
Gene LPS OVA
Prkar2b -8282 6952
Prkacb -8480 6487
Prkar1a -7928 6050
Creb1 -7586 5218
Calm1 -6748 5513
Prkx -7101 4043
Prkar1b -540 3038

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 -4529 -7623
Adcy8 659 -7263
Calm1 -6748 5513
Creb1 -7586 5218
Prkaca 1754 1
Prkacb -8480 6487
Prkar1a -7928 6050
Prkar1b -540 3038
Prkar2a 4258 6538
Prkar2b -8282 6952
Prkx -7101 4043





RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
metric value
setSize 125
pMANOVA 4.74e-24
p.adjustMANOVA 1.11e-21
s.dist 0.549
s.LPS 0.216
s.OVA 0.505
p.LPS 3.16e-05
p.OVA 1.76e-22



Top 20 genes
Gene LPS OVA
Timmdc1 7358 7321
Ndufa12 7000 7524
Ndufa10 5718 7440
Ndufaf1 5656 7102
Ndufa13 6594 5814
Ndufs2 4509 7475
Ndufaf2 4875 6156
Ndufaf6 4273 6562
Ndufs5 5917 4691
Sco2 4449 5971
Ucp2 3846 6674
Ndufa6 5354 4750
Taco1 5105 4949
Cox5b 4771 5260
Pm20d1 5123 4739
Surf1 3346 6964
Tmem126b 7103 3220
Ndufs6 5838 3822
Atp5b 2778 7882
Cox5a 2968 7058

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 609 1982
Atp5a1 -4981 7816
Atp5b 2778 7882
Atp5c1 -5845 7553
Atp5d 3991 1763
Atp5e 1651 1321
Atp5g1 5852 1062
Atp5g2 -6494 -3013
Atp5g3 3187 4175
Atp5h 1673 6023
Atp5j 4106 3761
Atp5j2 4356 1374
Atp5k 7165 360
Atp5l -831 1707
Atp5o 3995 3962
Atp5pb -1235 7181
Coq10a 3816 5337
Coq10b -3904 7973
Cox11 4945 -7061
Cox14 -791 -2269
Cox16 -5838 4704
Cox18 1919 4166
Cox19 6182 -4413
Cox20 494 5295
Cox4i1 2760 419
Cox5a 2968 7058
Cox5b 4771 5260
Cox6a1 533 6491
Cox6b1 3315 1740
Cox6c 1238 4894
Cox7a2l 1781 7723
Cox7b 367 4502
Cox7c 1268 5797
Cox8a 139 4536
Cyc1 1433 2317
Cycs -4451 7304
Dmac2l -2608 2800
Ecsit 1597 2337
Etfa -2759 3111
Etfb -1009 1993
Etfdh -5077 1102
Lrpprc -4806 -6900
mt-Atp6 -2872 6504
mt-Atp8 995 6360
mt-Co1 -2713 7833
mt-Co2 -2572 7454
mt-Co3 -1213 7243
mt-Cytb -1701 7370
mt-Nd1 -3441 7548
mt-Nd2 -4164 7400
mt-Nd3 -125 7653
mt-Nd4 -4486 7748
mt-Nd5 -4796 7473
mt-Nd6 -5973 7649
Ndufa1 4456 2809
Ndufa10 5718 7440
Ndufa11 2654 -920
Ndufa12 7000 7524
Ndufa13 6594 5814
Ndufa2 3299 -1358
Ndufa3 5067 -187
Ndufa4 648 6890
Ndufa5 1898 7073
Ndufa6 5354 4750
Ndufa7 1188 4513
Ndufa8 3955 1692
Ndufa9 214 -1151
Ndufab1 1655 5590
Ndufaf1 5656 7102
Ndufaf2 4875 6156
Ndufaf3 -710 -1141
Ndufaf4 -86 7831
Ndufaf5 2351 5653
Ndufaf6 4273 6562
Ndufaf7 953 -1197
Ndufb1 -3381 3410
Ndufb10 7581 314
Ndufb11 56 6444
Ndufb2 5314 1230
Ndufb3 6623 2487
Ndufb4 -1780 6524
Ndufb5 2198 7900
Ndufb6 2317 4164
Ndufb7 4406 1364
Ndufb8 3173 6155
Ndufb9 2240 6716
Ndufc1 575 7835
Ndufc2 -860 4793
Ndufs1 -1827 6348
Ndufs2 4509 7475
Ndufs3 -2765 5969
Ndufs4 2428 7476
Ndufs5 5917 4691
Ndufs6 5838 3822
Ndufs7 4331 2097
Ndufs8 2348 349
Ndufv1 5330 3458
Ndufv2 -2934 7853
Ndufv3 1928 201
Nubpl -4048 24
Pm20d1 5123 4739
Sco1 -8421 89
Sco2 4449 5971
Sdha -195 5193
Sdhb -706 4439
Sdhc 266 7697
Sdhd -1587 4982
Slc25a14 475 6787
Slc25a27 7308 -6518
Surf1 3346 6964
Taco1 5105 4949
Timmdc1 7358 7321
Tmem126b 7103 3220
Tmem186 333 -7230
Trap1 6958 -274
Ucp2 3846 6674
Ucp3 2555 3995
Uqcr10 2813 942
Uqcr11 2519 -883
Uqcrb 2531 7257
Uqcrc1 3153 823
Uqcrc2 -6455 5462
Uqcrfs1 -1373 3879
Uqcrh 1341 3289
Uqcrq 2766 4380





COLLAGEN CHAIN TRIMERIZATION
COLLAGEN CHAIN TRIMERIZATION
metric value
setSize 39
pMANOVA 9.42e-09
p.adjustMANOVA 3.33e-07
s.dist 0.543
s.LPS 0.423
s.OVA -0.34
p.LPS 4.78e-06
p.OVA 0.000238



Top 20 genes
Gene LPS OVA
Col12a1 7484 -6939
Col4a2 5547 -8019
Col26a1 7584 -5445
Col5a2 6826 -5301
Col2a1 6843 -4902
Col5a3 6555 -5016
Col27a1 7549 -4074
Col15a1 4515 -5176
Col6a2 6151 -2784
Col1a1 2553 -6409
Col6a3 4529 -3522
Col20a1 1834 -7961
Col6a1 5826 -2245
Col17a1 2349 -4168
Col16a1 7193 -959
Col9a3 3715 -1615
Col28a1 4669 -1079
Col6a5 2315 -1939
Col24a1 2945 -944
Col11a1 1208 -2092

Click HERE to show all gene set members

All member genes
LPS OVA
Col11a1 1208 -2092
Col11a2 7498 56
Col12a1 7484 -6939
Col13a1 7709 1905
Col14a1 -443 -4934
Col15a1 4515 -5176
Col16a1 7193 -959
Col17a1 2349 -4168
Col18a1 2998 366
Col19a1 -584 -7445
Col1a1 2553 -6409
Col1a2 7310 5849
Col20a1 1834 -7961
Col22a1 -5299 -7874
Col23a1 -3643 -8072
Col24a1 2945 -944
Col25a1 -5133 -4680
Col26a1 7584 -5445
Col27a1 7549 -4074
Col28a1 4669 -1079
Col2a1 6843 -4902
Col3a1 5851 1994
Col4a1 -836 -8183
Col4a2 5547 -8019
Col4a3 1821 -751
Col4a5 2443 175
Col5a1 -930 -7209
Col5a2 6826 -5301
Col5a3 6555 -5016
Col6a1 5826 -2245
Col6a2 6151 -2784
Col6a3 4529 -3522
Col6a5 2315 -1939
Col6a6 -5082 -3953
Col7a1 6654 704
Col8a1 -750 5027
Col8a2 -7494 -2436
Col9a2 7569 2977
Col9a3 3715 -1615





ASPARTATE AND ASPARAGINE METABOLISM
ASPARTATE AND ASPARAGINE METABOLISM
metric value
setSize 10
pMANOVA 0.012
p.adjustMANOVA 0.0522
s.dist 0.543
s.LPS 0.0137
s.OVA 0.542
p.LPS 0.94
p.OVA 0.00298



Top 20 genes
Gene LPS OVA
Got1 4369 6535
Naalad2 4080 5291
Folh1 2864 6636
Got2 2739 5948
Nat8l 1602 103

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -6225 7463
Aspa -7661 4932
Aspg 4191 -5652
Folh1 2864 6636
Got1 4369 6535
Got2 2739 5948
Naalad2 4080 5291
Nat8l 1602 103
Slc25a12 -2953 4508
Slc25a13 -6599 7144





SHC MEDIATED CASCADE FGFR3
SHC MEDIATED CASCADE FGFR3
metric value
setSize 12
pMANOVA 0.00658
p.adjustMANOVA 0.0319
s.dist 0.541
s.LPS 0.214
s.OVA 0.497
p.LPS 0.198
p.OVA 0.00289



Top 20 genes
Gene LPS OVA
Fgfr3 7713 7854
Fgf1 3814 7426
Hras 4448 6112
Fgf9 3660 4356
Fgf2 2652 5896
Shc1 7112 2124
Fgf18 621 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3814 7426
Fgf18 621 3642
Fgf2 2652 5896
Fgf5 5696 -1711
Fgf9 3660 4356
Fgfr3 7713 7854
Grb2 -3206 1149
Hras 4448 6112
Kras -6544 5582
Nras -4449 3852
Shc1 7112 2124
Sos1 -5908 675





SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
metric value
setSize 29
pMANOVA 1.51e-06
p.adjustMANOVA 3.59e-05
s.dist 0.54
s.LPS -0.216
s.OVA 0.495
p.LPS 0.0441
p.OVA 3.87e-06



Top 20 genes
Gene LPS OVA
Ube2d1 -7897 5951
Ube2d2a -7239 6099
Ube2l3 -5960 7068
Ube2a -6094 6500
Ube2w -7200 5278
Ube2g1 -4775 7664
Usp9x -7116 4819
Ube2b -6420 5232
Ube2e3 -5542 5775
Ube2q2 -5145 5294
Uchl3 -7805 3235
Ube2e1 -3590 5388
Uba6 -3045 4653
Ube2k -5379 2127
Ube2z -2083 4152
Ube2r2 -1047 7976
Ube2h -1764 2602
Cdc34 -124 3644

Click HERE to show all gene set members

All member genes
LPS OVA
Cdc34 -124 3644
Otulin 1051 5523
Rps27a 5724 6255
Uba1 1006 319
Uba52 3802 4658
Uba6 -3045 4653
Ubb 2567 4441
Ubc 3035 -673
Ube2a -6094 6500
Ube2b -6420 5232
Ube2d1 -7897 5951
Ube2d2a -7239 6099
Ube2e1 -3590 5388
Ube2e3 -5542 5775
Ube2g1 -4775 7664
Ube2g2 -128 -1818
Ube2h -1764 2602
Ube2k -5379 2127
Ube2l3 -5960 7068
Ube2q2 -5145 5294
Ube2r2 -1047 7976
Ube2s 23 838
Ube2t 4165 -677
Ube2w -7200 5278
Ube2z -2083 4152
Uchl3 -7805 3235
Usp5 2411 2439
Usp7 -882 -1717
Usp9x -7116 4819





SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
metric value
setSize 20
pMANOVA 0.000176
p.adjustMANOVA 0.00173
s.dist 0.535
s.LPS -0.00711
s.OVA 0.535
p.LPS 0.956
p.OVA 3.42e-05



Top 20 genes
Gene LPS OVA
Elovl4 -7081 6819
Acsl4 -6765 5740
Acsl3 -3924 7499
Elovl7 -7998 3626
Hacd2 -3851 7161
Acsl1 -4201 4261
Elovl2 -895 5556
Hsd17b12 -297 7822

Click HERE to show all gene set members

All member genes
LPS OVA
Acsbg1 7216 7514
Acsf3 -2705 -5399
Acsl1 -4201 4261
Acsl3 -3924 7499
Acsl4 -6765 5740
Acsl5 -5014 -954
Acsl6 433 3609
Elovl1 7795 8073
Elovl2 -895 5556
Elovl4 -7081 6819
Elovl5 403 7731
Elovl6 3613 1433
Elovl7 -7998 3626
Hacd1 2226 7377
Hacd2 -3851 7161
Hacd3 3735 7726
Hacd4 -3164 -252
Hsd17b12 -297 7822
Slc27a3 2679 -5075
Tecr 7169 4310





SELENOAMINO ACID METABOLISM
SELENOAMINO ACID METABOLISM
metric value
setSize 107
pMANOVA 2.8e-19
p.adjustMANOVA 2.72e-17
s.dist 0.534
s.LPS 0.332
s.OVA 0.419
p.LPS 3.06e-09
p.OVA 7.41e-14



Top 20 genes
Gene LPS OVA
Ahcy 7507 7407
Rps8 7270 7311
Rpl23a 6018 7527
Rps9 5472 7585
Rps29 6456 5766
Rps4x 5415 6684
Rps27a 5724 6255
Rpl23 5510 6488
Rpl6 5267 6717
Rps27l 4687 7436
Rpl37a 5426 6158
Rps25 4266 7815
Rpl24 4399 7498
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303
Rpl26 7185 3618
Rpl35 6124 4244

Click HERE to show all gene set members

All member genes
LPS OVA
Ahcy 7507 7407
Aimp1 1357 4827
Aimp2 6145 268
Cbs 2627 -568
Cth -1307 6925
Dars -7225 5281
Eef1e1 -1249 7100
Eefsec 40 -1800
Eprs 2559 864
Fau 3643 5715
Gsr -3328 5241
Hnmt -7290 7638
Iars 3349 -5245
Kars -281 7921
Lars -1611 -5963
Mars1 6051 -6555
Papss1 1036 6824
Papss2 -5684 5113
Pstk -3539 -5967
Qars -3243 1323
Rars -2991 1479
Rpl10 3682 -3710
Rpl10a 888 726
Rpl11 2279 5274
Rpl12 3716 -7461
Rpl13 3905 3221
Rpl13a 405 6092
Rpl14 3949 5504
Rpl15 -3304 3006
Rpl17 -2676 5572
Rpl18 1840 261
Rpl18a 3852 5324
Rpl19 2620 3552
Rpl21 2972 2665
Rpl22 728 5845
Rpl22l1 -3346 6909
Rpl23 5510 6488
Rpl23a 6018 7527
Rpl24 4399 7498
Rpl26 7185 3618
Rpl27 526 5183
Rpl27a 2841 2778
Rpl28 6953 831
Rpl29 -308 3647
Rpl3 2606 5904
Rpl30 3373 5170
Rpl31 3209 5661
Rpl32 3943 4605
Rpl34 -368 3499
Rpl35 6124 4244
Rpl35a 4655 5454
Rpl36 2401 -378
Rpl36a 920 4020
Rpl36al 2701 1803
Rpl37 5412 2940
Rpl37a 5426 6158
Rpl38 6480 3981
Rpl39 -2411 4849
Rpl4 867 6116
Rpl5 1280 6007
Rpl6 5267 6717
Rpl7 -1345 4993
Rpl7a 4403 2278
Rpl8 5074 2662
Rpl9 1475 5114
Rplp0 -305 5859
Rplp1 4411 -555
Rplp2 6466 773
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099
Sars 6475 110
Scly 907 -3433
Secisbp2 5874 -6792
Sephs2 -7562 3365
Sepsecs -6556 -5670
Txnrd1 -3552 611
Uba52 3802 4658





SIGNALING BY FGFR3 FUSIONS IN CANCER
SIGNALING BY FGFR3 FUSIONS IN CANCER
metric value
setSize 10
pMANOVA 0.0112
p.adjustMANOVA 0.0496
s.dist 0.534
s.LPS -0.187
s.OVA 0.5
p.LPS 0.306
p.OVA 0.00618



Top 20 genes
Gene LPS OVA
Kras -6544 5582
Gab1 -4807 7455
Frs2 -6072 4414
Nras -4449 3852
Sos1 -5908 675
Grb2 -3206 1149

Click HERE to show all gene set members

All member genes
LPS OVA
Fgfr3 7713 7854
Frs2 -6072 4414
Gab1 -4807 7455
Grb2 -3206 1149
Hras 4448 6112
Kras -6544 5582
Nras -4449 3852
Pik3ca 1380 6246
Pik3r1 -2752 -3932
Sos1 -5908 675





SCAVENGING BY CLASS A RECEPTORS
SCAVENGING BY CLASS A RECEPTORS
metric value
setSize 13
pMANOVA 0.00552
p.adjustMANOVA 0.0274
s.dist 0.533
s.LPS 0.446
s.OVA 0.291
p.LPS 0.00539
p.OVA 0.069



Top 20 genes
Gene LPS OVA
Calr 7700 7866
Colec12 7154 7768
Col1a2 7310 5849
Apoe 5889 6057
Masp1 2775 7046
Hsp90b1 2501 6286
Col3a1 5851 1994
Ftl1 1718 4540

Click HERE to show all gene set members

All member genes
LPS OVA
Apoe 5889 6057
Calr 7700 7866
Col1a1 2553 -6409
Col1a2 7310 5849
Col3a1 5851 1994
Col4a1 -836 -8183
Col4a2 5547 -8019
Colec12 7154 7768
Fth1 -274 6242
Ftl1 1718 4540
Hsp90b1 2501 6286
Masp1 2775 7046
Scara5 -6114 -2251





SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
metric value
setSize 11
pMANOVA 0.00861
p.adjustMANOVA 0.0397
s.dist 0.532
s.LPS -0.53
s.OVA 0.0487
p.LPS 0.00233
p.OVA 0.78



Top 20 genes
Gene LPS OVA
Pik3c3 -6229 6554
Fig4 -4249 6476
Mtmr2 -7581 2592
Mtmr7 -5720 2936
Pik3c2a -7898 293

Click HERE to show all gene set members

All member genes
LPS OVA
Fig4 -4249 6476
Mtm1 392 -321
Mtmr2 -7581 2592
Mtmr4 -5566 -3687
Mtmr7 -5720 2936
Mtmr9 -5916 -2158
Pik3c2a -7898 293
Pik3c3 -6229 6554
Pik3r4 -3274 -2478
Pikfyve -8013 -6164
Vac14 636 -1753





ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
metric value
setSize 10
pMANOVA 0.0183
p.adjustMANOVA 0.07
s.dist 0.53
s.LPS 0.231
s.OVA 0.477
p.LPS 0.206
p.OVA 0.00897



Top 20 genes
Gene LPS OVA
Calr 7700 7866
Nfyc 6349 6736
Hspa5 5096 7706
Ddit3 7455 4241
Xbp1 3569 7879
Hsp90b1 2501 6286

Click HERE to show all gene set members

All member genes
LPS OVA
Atf4 3753 -2100
Atf6 -7141 1162
Calr 7700 7866
Ddit3 7455 4241
Hsp90b1 2501 6286
Hspa5 5096 7706
Nfya -6485 -7155
Nfyb -8425 4902
Nfyc 6349 6736
Xbp1 3569 7879





ACTIVATION OF RAC1
ACTIVATION OF RAC1
metric value
setSize 13
pMANOVA 0.00318
p.adjustMANOVA 0.0184
s.dist 0.53
s.LPS -0.496
s.OVA 0.185
p.LPS 0.00194
p.OVA 0.247



Top 20 genes
Gene LPS OVA
Rac1 -7037 7671
Pak1 -7208 4466
Sos2 -6232 4049
Pak5 -5209 3533
Pak2 -2251 7895
Pak3 -3656 4266
Robo1 -7095 1594
Sos1 -5908 675
Nck1 -524 4853

Click HERE to show all gene set members

All member genes
LPS OVA
Nck1 -524 4853
Nck2 -1091 -3951
Pak1 -7208 4466
Pak2 -2251 7895
Pak3 -3656 4266
Pak4 -1893 -2846
Pak5 -5209 3533
Pak6 -2703 -7846
Rac1 -7037 7671
Robo1 -7095 1594
Slit2 -8699 -6964
Sos1 -5908 675
Sos2 -6232 4049





TRIGLYCERIDE CATABOLISM
TRIGLYCERIDE CATABOLISM
metric value
setSize 14
pMANOVA 0.00254
p.adjustMANOVA 0.0154
s.dist 0.529
s.LPS -0.0521
s.OVA 0.526
p.LPS 0.736
p.OVA 0.000653



Top 20 genes
Gene LPS OVA
Prkacb -8480 6487
Ppp1cb -5959 6602
Abhd5 -4558 6978
Gpd2 -7539 3430
Mgll -3059 869
Ppp1ca -155 4188

Click HERE to show all gene set members

All member genes
LPS OVA
Abhd5 -4558 6978
Cav1 4233 7991
Fabp3 1087 1580
Fabp5 5925 6216
Fabp7 -7506 -5726
Gpd2 -7539 3430
Lipe 3391 4697
Mgll -3059 869
Plin3 6769 7827
Ppp1ca -155 4188
Ppp1cb -5959 6602
Ppp1cc 1456 7036
Prkaca 1754 1
Prkacb -8480 6487





TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
metric value
setSize 15
pMANOVA 0.00265
p.adjustMANOVA 0.0158
s.dist 0.525
s.LPS 0.198
s.OVA 0.487
p.LPS 0.185
p.OVA 0.0011



Top 20 genes
Gene LPS OVA
Hif3a 7457 6471
Sall1 6661 6322
Klf4 6482 5943
Hhex 5764 6582
Epas1 6950 3972
Sox2 3258 7703
Stat3 6308 3858
Fgf2 2652 5896
Smad4 1314 6948

Click HERE to show all gene set members

All member genes
LPS OVA
Epas1 6950 3972
Fgf2 2652 5896
Foxp1 -3598 2370
Hhex 5764 6582
Hif3a 7457 6471
Klf4 6482 5943
Nr6a1 -2716 -5994
Pbx1 -2583 578
Sall1 6661 6322
Smad2 -7382 3105
Smad4 1314 6948
Sox2 3258 7703
Stat3 6308 3858
Tsc22d1 -7051 3276
Zic3 -6060 415





PI 3K CASCADE FGFR3
PI 3K CASCADE FGFR3
metric value
setSize 12
pMANOVA 0.00858
p.adjustMANOVA 0.0397
s.dist 0.525
s.LPS 0.188
s.OVA 0.491
p.LPS 0.26
p.OVA 0.00325



Top 20 genes
Gene LPS OVA
Fgfr3 7713 7854
Fgf1 3814 7426
Fgf9 3660 4356
Fgf2 2652 5896
Ptpn11 4274 3561
Pik3ca 1380 6246
Fgf18 621 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3814 7426
Fgf18 621 3642
Fgf2 2652 5896
Fgf5 5696 -1711
Fgf9 3660 4356
Fgfr3 7713 7854
Frs2 -6072 4414
Gab1 -4807 7455
Grb2 -3206 1149
Pik3ca 1380 6246
Pik3r1 -2752 -3932
Ptpn11 4274 3561





SHC MEDIATED CASCADE FGFR4
SHC MEDIATED CASCADE FGFR4
metric value
setSize 10
pMANOVA 0.0176
p.adjustMANOVA 0.0685
s.dist 0.524
s.LPS 0.0837
s.OVA 0.517
p.LPS 0.647
p.OVA 0.00464



Top 20 genes
Gene LPS OVA
Fgf1 3814 7426
Hras 4448 6112
Fgf9 3660 4356
Fgf2 2652 5896
Shc1 7112 2124
Fgf18 621 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3814 7426
Fgf18 621 3642
Fgf2 2652 5896
Fgf9 3660 4356
Grb2 -3206 1149
Hras 4448 6112
Kras -6544 5582
Nras -4449 3852
Shc1 7112 2124
Sos1 -5908 675





FRS MEDIATED FGFR3 SIGNALING
FRS MEDIATED FGFR3 SIGNALING
metric value
setSize 14
pMANOVA 0.00387
p.adjustMANOVA 0.0214
s.dist 0.523
s.LPS 0.151
s.OVA 0.501
p.LPS 0.327
p.OVA 0.00117



Top 20 genes
Gene LPS OVA
Fgfr3 7713 7854
Fgf1 3814 7426
Hras 4448 6112
Fgf9 3660 4356
Fgf2 2652 5896
Ptpn11 4274 3561
Frs3 4213 2457
Fgf18 621 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3814 7426
Fgf18 621 3642
Fgf2 2652 5896
Fgf5 5696 -1711
Fgf9 3660 4356
Fgfr3 7713 7854
Frs2 -6072 4414
Frs3 4213 2457
Grb2 -3206 1149
Hras 4448 6112
Kras -6544 5582
Nras -4449 3852
Ptpn11 4274 3561
Sos1 -5908 675





COMPLEMENT CASCADE
COMPLEMENT CASCADE
metric value
setSize 22
pMANOVA 0.00023
p.adjustMANOVA 0.00218
s.dist 0.521
s.LPS 0.344
s.OVA 0.391
p.LPS 0.00523
p.OVA 0.00148



Top 20 genes
Gene LPS OVA
C1qb 6801 7124
C2 7641 5522
Serping1 6699 6018
C1qc 4298 7484
Clu 4695 6252
C1qa 2949 7432
Cfh 2524 7998
Masp1 2775 7046
C4b 4807 3713
Cr1l 1897 4807
Pros1 1018 7566
Cd81 863 7406
Cd55 762 4843

Click HERE to show all gene set members

All member genes
LPS OVA
C1qa 2949 7432
C1qb 6801 7124
C1qc 4298 7484
C2 7641 5522
C3ar1 -2326 5341
C4b 4807 3713
C8g 2962 -6236
Cd46 4161 -2943
Cd55 762 4843
Cd59b -1250 -2389
Cd81 863 7406
Cfb -7655 -6025
Cfh 2524 7998
Cfp 7564 -1864
Clu 4695 6252
Cr1l 1897 4807
Gzmm -541 -2229
Masp1 2775 7046
Masp2 5861 -2260
Pros1 1018 7566
Serping1 6699 6018
Vtn -4361 2288





FRS MEDIATED FGFR4 SIGNALING
FRS MEDIATED FGFR4 SIGNALING
metric value
setSize 12
pMANOVA 0.00793
p.adjustMANOVA 0.0373
s.dist 0.52
s.LPS 0.032
s.OVA 0.519
p.LPS 0.848
p.OVA 0.00187



Top 20 genes
Gene LPS OVA
Fgf1 3814 7426
Hras 4448 6112
Fgf9 3660 4356
Fgf2 2652 5896
Ptpn11 4274 3561
Frs3 4213 2457
Fgf18 621 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3814 7426
Fgf18 621 3642
Fgf2 2652 5896
Fgf9 3660 4356
Frs2 -6072 4414
Frs3 4213 2457
Grb2 -3206 1149
Hras 4448 6112
Kras -6544 5582
Nras -4449 3852
Ptpn11 4274 3561
Sos1 -5908 675





CRMPS IN SEMA3A SIGNALING
CRMPS IN SEMA3A SIGNALING
metric value
setSize 16
pMANOVA 0.00181
p.adjustMANOVA 0.0117
s.dist 0.517
s.LPS -0.0767
s.OVA -0.511
p.LPS 0.595
p.OVA 0.000397



Top 20 genes
Gene LPS OVA
Plxna4 -4983 -7926
Crmp1 -4703 -6303
Cdk5r1 -8262 -2366
Plxna1 -1784 -7427
Plxna2 -2662 -4388
Gsk3b -5885 -1837
Nrp1 -1540 -3877

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk5 3039 -4309
Cdk5r1 -8262 -2366
Crmp1 -4703 -6303
Dpysl2 1168 -7146
Dpysl3 585 -5919
Dpysl4 3568 -6191
Dpysl5 2268 -5612
Fes 4947 -724
Fyn -3968 235
Gsk3b -5885 -1837
Nrp1 -1540 -3877
Plxna1 -1784 -7427
Plxna2 -2662 -4388
Plxna3 6890 -7837
Plxna4 -4983 -7926
Sema3a -6382 871





NONSENSE MEDIATED DECAY NMD
NONSENSE MEDIATED DECAY NMD
metric value
setSize 109
pMANOVA 3.99e-18
p.adjustMANOVA 3.32e-16
s.dist 0.513
s.LPS 0.353
s.OVA 0.372
p.LPS 1.99e-10
p.OVA 1.85e-11



Top 20 genes
Gene LPS OVA
Rps8 7270 7311
Rpl23a 6018 7527
Rps9 5472 7585
Rbm8a 5183 7525
Rps29 6456 5766
Rps4x 5415 6684
Rps27a 5724 6255
Rpl23 5510 6488
Rpl6 5267 6717
Rps27l 4687 7436
Rpl37a 5426 6158
Rps25 4266 7815
Rpl24 4399 7498
Rps3a1 4133 7052
Rps28 7414 3878
Rps26 5413 5207
Rps18 5149 5466
Rps19 5286 5303
Rpl26 7185 3618
Rpl35 6124 4244

Click HERE to show all gene set members

All member genes
LPS OVA
Casc3 5007 -8124
Dcp1a -2685 -3378
Eif4a3 4668 4493
Eif4g1 5629 -6391
Etf1 -6354 5118
Fau 3643 5715
Gspt1 -5187 4876
Gspt2 1401 -2985
Magoh -2103 -2348
Magohb 3205 4727
Ncbp1 628 4294
Ncbp2 1686 -2075
Pabpc1 -1115 6439
Pnrc2 -7671 6687
Ppp2ca -2508 5976
Ppp2r1a 137 5753
Ppp2r2a -4840 7647
Rbm8a 5183 7525
Rnps1 1851 1663
Rpl10 3682 -3710
Rpl10a 888 726
Rpl11 2279 5274
Rpl12 3716 -7461
Rpl13 3905 3221
Rpl13a 405 6092
Rpl14 3949 5504
Rpl15 -3304 3006
Rpl17 -2676 5572
Rpl18 1840 261
Rpl18a 3852 5324
Rpl19 2620 3552
Rpl21 2972 2665
Rpl22 728 5845
Rpl22l1 -3346 6909
Rpl23 5510 6488
Rpl23a 6018 7527
Rpl24 4399 7498
Rpl26 7185 3618
Rpl27 526 5183
Rpl27a 2841 2778
Rpl28 6953 831
Rpl29 -308 3647
Rpl3 2606 5904
Rpl30 3373 5170
Rpl31 3209 5661
Rpl32 3943 4605
Rpl34 -368 3499
Rpl35 6124 4244
Rpl35a 4655 5454
Rpl36 2401 -378
Rpl36a 920 4020
Rpl36al 2701 1803
Rpl37 5412 2940
Rpl37a 5426 6158
Rpl38 6480 3981
Rpl39 -2411 4849
Rpl4 867 6116
Rpl5 1280 6007
Rpl6 5267 6717
Rpl7 -1345 4993
Rpl7a 4403 2278
Rpl8 5074 2662
Rpl9 1475 5114
Rplp0 -305 5859
Rplp1 4411 -555
Rplp2 6466 773
Rps10 2928 1096
Rps11 3857 3503
Rps12 1204 -529
Rps13 5834 2142
Rps14 3093 -1425
Rps15 2975 682
Rps15a -1929 -367
Rps16 3364 1896
Rps17 3863 2721
Rps18 5149 5466
Rps19 5286 5303
Rps2 5570 1407
Rps20 -237 5393
Rps21 5590 3174
Rps23 866 6779
Rps24 3023 6359
Rps25 4266 7815
Rps26 5413 5207
Rps27 1644 2195
Rps27a 5724 6255
Rps27l 4687 7436
Rps28 7414 3878
Rps29 6456 5766
Rps3 -767 1372
Rps3a1 4133 7052
Rps4x 5415 6684
Rps5 2208 4924
Rps6 3674 2038
Rps7 2682 6269
Rps8 7270 7311
Rps9 5472 7585
Rpsa 2566 3099
Smg1 -2421 -8045
Smg5 2159 -6471
Smg6 -4234 -8330
Smg7 -3529 -5979
Smg8 -2113 3843
Smg9 1679 -4677
Uba52 3802 4658
Upf1 4554 -7637
Upf2 5791 -5910
Upf3a 7290 -3315
Upf3b 5681 2083





PI 3K CASCADE FGFR4
PI 3K CASCADE FGFR4
metric value
setSize 10
pMANOVA 0.0202
p.adjustMANOVA 0.0752
s.dist 0.512
s.LPS 0.0519
s.OVA 0.51
p.LPS 0.776
p.OVA 0.00525



Top 20 genes
Gene LPS OVA
Fgf1 3814 7426
Fgf9 3660 4356
Fgf2 2652 5896
Ptpn11 4274 3561
Pik3ca 1380 6246
Fgf18 621 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3814 7426
Fgf18 621 3642
Fgf2 2652 5896
Fgf9 3660 4356
Frs2 -6072 4414
Gab1 -4807 7455
Grb2 -3206 1149
Pik3ca 1380 6246
Pik3r1 -2752 -3932
Ptpn11 4274 3561





BLOOD GROUP SYSTEMS BIOSYNTHESIS
BLOOD GROUP SYSTEMS BIOSYNTHESIS
metric value
setSize 13
pMANOVA 0.00514
p.adjustMANOVA 0.0263
s.dist 0.51
s.LPS -0.125
s.OVA 0.495
p.LPS 0.435
p.OVA 0.00201



Top 20 genes
Gene LPS OVA
B3galt1 -7820 5267
Fut9 -7505 5208
B3galt2 -5775 6436
B3galt5 -4698 6494
St3gal6 -1939 5359
Fut10 -1390 3960
Fut2 -1200 2105
St6galnac6 -701 3136

Click HERE to show all gene set members

All member genes
LPS OVA
B3galt1 -7820 5267
B3galt2 -5775 6436
B3galt4 -8291 -1978
B3galt5 -4698 6494
Fut10 -1390 3960
Fut11 6256 4652
Fut2 -1200 2105
Fut4 544 839
Fut9 -7505 5208
St3gal3 6215 1136
St3gal4 6715 8048
St3gal6 -1939 5359
St6galnac6 -701 3136





G BETA GAMMA SIGNALLING THROUGH CDC42
G BETA GAMMA SIGNALLING THROUGH CDC42
metric value
setSize 18
pMANOVA 0.00059
p.adjustMANOVA 0.00468
s.dist 0.51
s.LPS -0.223
s.OVA 0.459
p.LPS 0.102
p.OVA 0.000751



Top 20 genes
Gene LPS OVA
Gng12 -6343 7763
Cdc42 -6735 6328
Gng10 -5608 7086
Pak1 -7208 4466
Gnb4 -8083 2629
Gng2 -8001 1552
Gng5 -818 7008
Gnb1 -6679 593
Gng13 -3690 919
Gng11 -360 6593
Gng7 -405 5103
Gnb2 -173 1359

Click HERE to show all gene set members

All member genes
LPS OVA
Arhgef6 -5442 -4411
Cdc42 -6735 6328
Gnb1 -6679 593
Gnb2 -173 1359
Gnb4 -8083 2629
Gnb5 2323 6657
Gng10 -5608 7086
Gng11 -360 6593
Gng12 -6343 7763
Gng13 -3690 919
Gng2 -8001 1552
Gng3 4650 4213
Gng4 689 2011
Gng5 -818 7008
Gng7 -405 5103
Gng8 5765 2069
Gngt2 4502 2829
Pak1 -7208 4466





FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
metric value
setSize 18
pMANOVA 0.00117
p.adjustMANOVA 0.00835
s.dist 0.509
s.LPS 0.157
s.OVA 0.485
p.LPS 0.248
p.OVA 0.000372



Top 20 genes
Gene LPS OVA
Atp5b 2778 7882
Atp5o 3995 3962
Atp5j 4106 3761
Atp5g3 3187 4175
Atp5h 1673 6023
Atp5d 3991 1763
mt-Atp8 995 6360
Atp5g1 5852 1062
Atp5j2 4356 1374
Atp5k 7165 360
Atp5e 1651 1321

Click HERE to show all gene set members

All member genes
LPS OVA
Atp5a1 -4981 7816
Atp5b 2778 7882
Atp5c1 -5845 7553
Atp5d 3991 1763
Atp5e 1651 1321
Atp5g1 5852 1062
Atp5g2 -6494 -3013
Atp5g3 3187 4175
Atp5h 1673 6023
Atp5j 4106 3761
Atp5j2 4356 1374
Atp5k 7165 360
Atp5l -831 1707
Atp5o 3995 3962
Atp5pb -1235 7181
Dmac2l -2608 2800
mt-Atp6 -2872 6504
mt-Atp8 995 6360





PLATELET SENSITIZATION BY LDL
PLATELET SENSITIZATION BY LDL
metric value
setSize 15
pMANOVA 0.0034
p.adjustMANOVA 0.0191
s.dist 0.505
s.LPS 0.0548
s.OVA 0.502
p.LPS 0.713
p.OVA 0.000754



Top 20 genes
Gene LPS OVA
Ppp2r5b 7586 7672
Ptpn6 7461 5265
Ppp2r5d 5358 6043
Ptpn11 4274 3561
Pla2g4a 2009 7129
Ppp2r1a 137 5753

Click HERE to show all gene set members

All member genes
LPS OVA
Lrp8 -934 -8372
Mapk14 2008 -4069
Pecam1 -7441 6259
Pla2g4a 2009 7129
Ppp2ca -2508 5976
Ppp2cb -7982 7856
Ppp2r1a 137 5753
Ppp2r1b -932 -3513
Ppp2r5a -1875 7784
Ppp2r5b 7586 7672
Ppp2r5c -5783 6189
Ppp2r5d 5358 6043
Ppp2r5e -1667 5854
Ptpn11 4274 3561
Ptpn6 7461 5265





RHOBTB3 ATPASE CYCLE
RHOBTB3 ATPASE CYCLE
metric value
setSize 10
pMANOVA 0.0186
p.adjustMANOVA 0.0706
s.dist 0.505
s.LPS -0.141
s.OVA 0.485
p.LPS 0.44
p.OVA 0.00794



Top 20 genes
Gene LPS OVA
Rhobtb3 -7960 7461
Cul3 -7373 7410
Vhl -7890 5205
Rab9b -3612 4711
Lrrc41 -5188 2726
Rab9 -478 6858

Click HERE to show all gene set members

All member genes
LPS OVA
Ccne1 2894 -6904
Cul3 -7373 7410
Hgs 4707 612
Htr7 1748 2244
Lrrc41 -5188 2726
Plin3 6769 7827
Rab9 -478 6858
Rab9b -3612 4711
Rhobtb3 -7960 7461
Vhl -7890 5205





CITRIC ACID CYCLE TCA CYCLE
CITRIC ACID CYCLE TCA CYCLE
metric value
setSize 22
pMANOVA 0.000268
p.adjustMANOVA 0.00244
s.dist 0.504
s.LPS 0.0887
s.OVA 0.497
p.LPS 0.472
p.OVA 5.54e-05



Top 20 genes
Gene LPS OVA
Idh2 7464 6235
Suclg2 3745 7030
Suclg1 3077 5284
Ogdh 2804 3778
Aco2 1818 4190
Fahd1 3261 1561
Nnt 1196 4009
Mdh2 1032 3679
Sdhc 266 7697

Click HERE to show all gene set members

All member genes
LPS OVA
Aco2 1818 4190
Cs -3353 4954
Dld -7039 4580
Dlst 7423 -352
Fahd1 3261 1561
Fh1 -3928 5150
Idh2 7464 6235
Idh3a -3032 7846
Idh3b -152 -2452
Idh3g 3632 -2172
Mdh2 1032 3679
Me2 -3932 3445
Me3 -2882 55
Nnt 1196 4009
Ogdh 2804 3778
Sdha -195 5193
Sdhb -706 4439
Sdhc 266 7697
Sdhd -1587 4982
Sucla2 -3185 6859
Suclg1 3077 5284
Suclg2 3745 7030





GLYCOGEN STORAGE DISEASES
GLYCOGEN STORAGE DISEASES
metric value
setSize 12
pMANOVA 0.0157
p.adjustMANOVA 0.063
s.dist 0.491
s.LPS 0.186
s.OVA 0.455
p.LPS 0.266
p.OVA 0.00635



Top 20 genes
Gene LPS OVA
Rps27a 5724 6255
Gys1 7521 3080
Uba52 3802 4658
Nhlrc1 2573 5001
Ubb 2567 4441
Gaa 452 3599
Ppp1r3c 175 4963

Click HERE to show all gene set members

All member genes
LPS OVA
Epm2a -8649 -6608
G6pc3 -100 3449
Gaa 452 3599
Gbe1 -3444 7409
Gyg -912 7242
Gys1 7521 3080
Nhlrc1 2573 5001
Ppp1r3c 175 4963
Rps27a 5724 6255
Uba52 3802 4658
Ubb 2567 4441
Ubc 3035 -673





SEROTONIN RECEPTORS
SEROTONIN RECEPTORS
metric value
setSize 10
pMANOVA 0.0207
p.adjustMANOVA 0.0764
s.dist 0.491
s.LPS -0.393
s.OVA 0.294
p.LPS 0.0313
p.OVA 0.107



Top 20 genes
Gene LPS OVA
Htr2a -7123 6386
Htr2c -6680 4038
Htr1d -5041 3423
Htr1f -2696 3774

Click HERE to show all gene set members

All member genes
LPS OVA
Htr1a 57 3368
Htr1b 1178 5913
Htr1d -5041 3423
Htr1f -2696 3774
Htr2a -7123 6386
Htr2c -6680 4038
Htr4 -8665 -2934
Htr5a -7169 -1893
Htr6 -2864 -1932
Htr7 1748 2244





THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 172
pMANOVA 1.87e-26
p.adjustMANOVA 7.28e-24
s.dist 0.489
s.LPS 0.139
s.OVA 0.469
p.LPS 0.00169
p.OVA 2.58e-26



Top 20 genes
Gene LPS OVA
Timmdc1 7358 7321
Ndufa12 7000 7524
Idh2 7464 6235
Ndufa10 5718 7440
Ndufaf1 5656 7102
Ndufa13 6594 5814
Rxra 5741 6257
Ldhb 5974 5890
Ndufs2 4509 7475
Ndufaf2 4875 6156
Ndufaf6 4273 6562
Ndufs5 5917 4691
Sco2 4449 5971
Suclg2 3745 7030
Ucp2 3846 6674
Ndufa6 5354 4750
Taco1 5105 4949
Cox5b 4771 5260
Pm20d1 5123 4739
Surf1 3346 6964

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 609 1982
Aco2 1818 4190
Adhfe1 -4174 4448
Atp5a1 -4981 7816
Atp5b 2778 7882
Atp5c1 -5845 7553
Atp5d 3991 1763
Atp5e 1651 1321
Atp5g1 5852 1062
Atp5g2 -6494 -3013
Atp5g3 3187 4175
Atp5h 1673 6023
Atp5j 4106 3761
Atp5j2 4356 1374
Atp5k 7165 360
Atp5l -831 1707
Atp5o 3995 3962
Atp5pb -1235 7181
Bsg -2243 3330
Coq10a 3816 5337
Coq10b -3904 7973
Cox11 4945 -7061
Cox14 -791 -2269
Cox16 -5838 4704
Cox18 1919 4166
Cox19 6182 -4413
Cox20 494 5295
Cox4i1 2760 419
Cox5a 2968 7058
Cox5b 4771 5260
Cox6a1 533 6491
Cox6b1 3315 1740
Cox6c 1238 4894
Cox7a2l 1781 7723
Cox7b 367 4502
Cox7c 1268 5797
Cox8a 139 4536
Cs -3353 4954
Cyc1 1433 2317
Cycs -4451 7304
D2hgdh -1034 -1142
Dlat -460 7558
Dld -7039 4580
Dlst 7423 -352
Dmac2l -2608 2800
Ecsit 1597 2337
Etfa -2759 3111
Etfb -1009 1993
Etfdh -5077 1102
Fahd1 3261 1561
Fh1 -3928 5150
Glo1 -64 6680
Gstz1 -1247 -4279
Hagh 3305 1620
Idh2 7464 6235
Idh3a -3032 7846
Idh3b -152 -2452
Idh3g 3632 -2172
L2hgdh -3607 -1910
Ldha -3160 -113
Ldhb 5974 5890
Lrpprc -4806 -6900
Mdh2 1032 3679
Me1 -1765 5726
Me2 -3932 3445
Me3 -2882 55
Mpc1 -92 7175
Mpc2 -2654 5320
mt-Atp6 -2872 6504
mt-Atp8 995 6360
mt-Co1 -2713 7833
mt-Co2 -2572 7454
mt-Co3 -1213 7243
mt-Cytb -1701 7370
mt-Nd1 -3441 7548
mt-Nd2 -4164 7400
mt-Nd3 -125 7653
mt-Nd4 -4486 7748
mt-Nd5 -4796 7473
mt-Nd6 -5973 7649
Ndufa1 4456 2809
Ndufa10 5718 7440
Ndufa11 2654 -920
Ndufa12 7000 7524
Ndufa13 6594 5814
Ndufa2 3299 -1358
Ndufa3 5067 -187
Ndufa4 648 6890
Ndufa5 1898 7073
Ndufa6 5354 4750
Ndufa7 1188 4513
Ndufa8 3955 1692
Ndufa9 214 -1151
Ndufab1 1655 5590
Ndufaf1 5656 7102
Ndufaf2 4875 6156
Ndufaf3 -710 -1141
Ndufaf4 -86 7831
Ndufaf5 2351 5653
Ndufaf6 4273 6562
Ndufaf7 953 -1197
Ndufb1 -3381 3410
Ndufb10 7581 314
Ndufb11 56 6444
Ndufb2 5314 1230
Ndufb3 6623 2487
Ndufb4 -1780 6524
Ndufb5 2198 7900
Ndufb6 2317 4164
Ndufb7 4406 1364
Ndufb8 3173 6155
Ndufb9 2240 6716
Ndufc1 575 7835
Ndufc2 -860 4793
Ndufs1 -1827 6348
Ndufs2 4509 7475
Ndufs3 -2765 5969
Ndufs4 2428 7476
Ndufs5 5917 4691
Ndufs6 5838 3822
Ndufs7 4331 2097
Ndufs8 2348 349
Ndufv1 5330 3458
Ndufv2 -2934 7853
Ndufv3 1928 201
Nnt 1196 4009
Nubpl -4048 24
Ogdh 2804 3778
Pdha1 -458 7224
Pdhb -1926 5115
Pdhx -6802 4813
Pdk1 -5357 -8266
Pdk2 294 328
Pdk3 -3880 7929
Pdk4 -7649 5955
Pdp1 -670 5799
Pdp2 -7247 -6915
Pdpr -3299 -2913
Pm20d1 5123 4739
Ppard 5745 3247
Rxra 5741 6257
Sco1 -8421 89
Sco2 4449 5971
Sdha -195 5193
Sdhb -706 4439
Sdhc 266 7697
Sdhd -1587 4982
Slc16a1 -8745 4021
Slc16a3 -3574 -1971
Slc16a8 -8439 -7479
Slc25a14 475 6787
Slc25a27 7308 -6518
Sucla2 -3185 6859
Suclg1 3077 5284
Suclg2 3745 7030
Surf1 3346 6964
Taco1 5105 4949
Timmdc1 7358 7321
Tmem126b 7103 3220
Tmem186 333 -7230
Trap1 6958 -274
Ucp2 3846 6674
Ucp3 2555 3995
Uqcr10 2813 942
Uqcr11 2519 -883
Uqcrb 2531 7257
Uqcrc1 3153 823
Uqcrc2 -6455 5462
Uqcrfs1 -1373 3879
Uqcrh 1341 3289
Uqcrq 2766 4380
Vdac1 1586 5839





DARPP 32 EVENTS
DARPP 32 EVENTS
metric value
setSize 23
pMANOVA 0.000169
p.adjustMANOVA 0.0017
s.dist 0.488
s.LPS -0.201
s.OVA 0.445
p.LPS 0.0953
p.OVA 0.000221



Top 20 genes
Gene LPS OVA
Ppp2cb -7982 7856
Prkar2b -8282 6952
Prkacb -8480 6487
Ppp3r1 -7652 6887
Ppp3cb -7424 6483
Prkar1a -7928 6050
Calm1 -6748 5513
Ppp3ca -4160 6738
Pde4b -4172 5574
Ppp2ca -2508 5976
Prkar1b -540 3038
Ppp1ca -155 4188

Click HERE to show all gene set members

All member genes
LPS OVA
Calm1 -6748 5513
Cdk5 3039 -4309
Pde4a 5034 -424
Pde4b -4172 5574
Pde4c 7631 788
Pde4d -4829 -3794
Ppp1ca -155 4188
Ppp1r1b 926 4991
Ppp2ca -2508 5976
Ppp2cb -7982 7856
Ppp2r1a 137 5753
Ppp2r1b -932 -3513
Ppp2r5d 5358 6043
Ppp3ca -4160 6738
Ppp3cb -7424 6483
Ppp3cc -5407 -3735
Ppp3r1 -7652 6887
Prkaca 1754 1
Prkacb -8480 6487
Prkar1a -7928 6050
Prkar1b -540 3038
Prkar2a 4258 6538
Prkar2b -8282 6952





ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
metric value
setSize 16
pMANOVA 0.0046
p.adjustMANOVA 0.0245
s.dist 0.486
s.LPS 0.437
s.OVA 0.212
p.LPS 0.00245
p.OVA 0.142



Top 20 genes
Gene LPS OVA
Cd14 6396 7712
Ticam2 6674 5846
Rps27a 5724 6255
Uba52 3802 4658
Tank 2705 6343
Tlr4 3819 4143
Ptpn11 4274 3561
Ticam1 4215 2894
Ubb 2567 4441
Ikbke 4861 1022

Click HERE to show all gene set members

All member genes
LPS OVA
Cd14 6396 7712
Ikbke 4861 1022
Irf3 7040 -2568
Irf7 -8747 1140
Ptpn11 4274 3561
Rps27a 5724 6255
Sarm1 -164 -6603
Tank 2705 6343
Tbk1 641 -6087
Ticam1 4215 2894
Ticam2 6674 5846
Tlr4 3819 4143
Traf3 3451 -7167
Uba52 3802 4658
Ubb 2567 4441
Ubc 3035 -673





Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.4            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] highr_0.11              later_1.3.2             DelayedArray_0.30.1    
## [28] BiocParallel_1.38.0     parallel_4.4.0          R6_2.5.1               
## [31] bslib_0.7.0             stringi_1.8.4           RColorBrewer_1.1-3     
## [34] jquerylib_0.1.4         Rcpp_1.0.12             assertthat_0.2.1       
## [37] knitr_1.47              httpuv_1.6.15           Matrix_1.7-0           
## [40] tidyselect_1.2.1        rstudioapi_0.16.0       abind_1.4-5            
## [43] yaml_2.3.8              codetools_0.2-20        lattice_0.22-6         
## [46] plyr_1.8.9              withr_3.0.0             shiny_1.8.1.1          
## [49] evaluate_0.23           polyclip_1.10-6         ggstats_0.6.0          
## [52] xml2_1.3.6              pillar_1.9.0            KernSmooth_2.23-24     
## [55] generics_0.1.3          munsell_0.5.1           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [61] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [64] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [70] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [73] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [76] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [79] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [82] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report