date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik 0.2684894 1.8312366
0610009E02Rik -0.7521235 -0.1037028
0610009L18Rik -1.1838923 -0.0756377
0610010K14Rik -0.0433030 0.4176706
0610012G03Rik -0.1930476 0.0087096
0610030E20Rik 1.0496464 -1.6095238

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 16550
duplicated_genes_present 0
num_profile_genes_in_sets 8251
num_profile_genes_not_in_sets 8299
profile_pearson_correl 0.09156
profile_spearman_correl 0.0695

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 438
num_genesets_included 1166

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 264

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.59e-25 1.05e-22 0.680 0.44300 0.5150 9.24e-13 9.30e-17
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.53e-04 6.42e-03 0.658 0.07890 0.6540 6.50e-01 1.74e-04
MET ACTIVATES RAP1 AND RAC1 11 1.29e-03 8.88e-03 0.618 -0.56700 0.2450 1.12e-03 1.60e-01
COMPLEX I BIOGENESIS 56 1.26e-13 7.33e-12 0.612 0.29500 0.5360 1.33e-04 3.88e-12
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 1.66e-21 2.15e-19 0.603 0.38000 0.4680 1.94e-10 4.37e-15
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.27e-03 1.43e-02 0.601 0.37200 0.4720 2.57e-02 4.65e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 3.87e-23 6.45e-21 0.588 0.32400 0.4910 8.10e-09 2.38e-18
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 3.08e-05 4.27e-04 0.588 -0.22200 0.5450 9.34e-02 3.94e-05
INITIAL TRIGGERING OF COMPLEMENT 10 8.52e-03 3.96e-02 0.582 0.47400 0.3370 9.42e-03 6.49e-02
CD28 DEPENDENT VAV1 PATHWAY 10 4.58e-03 2.45e-02 0.578 -0.40900 0.4080 2.51e-02 2.53e-02
EUKARYOTIC TRANSLATION INITIATION 114 6.39e-23 9.31e-21 0.565 0.30600 0.4750 1.75e-08 1.98e-18
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.44e-03 1.49e-02 0.557 0.03560 0.5560 8.24e-01 5.24e-04
RESPIRATORY ELECTRON TRANSPORT 102 4.13e-20 4.38e-18 0.553 0.21000 0.5120 2.46e-04 3.92e-19
PINK1 PRKN MEDIATED MITOPHAGY 22 6.14e-05 7.38e-04 0.553 0.18800 0.5210 1.27e-01 2.36e-05
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 5.73e-03 2.83e-02 0.553 0.32000 0.4510 5.53e-02 6.81e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 9.83e-12 4.77e-10 0.551 0.27000 0.4800 3.32e-04 1.75e-10
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 4.65e-03 2.45e-02 0.551 -0.43200 0.3420 1.30e-02 4.97e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 4.86e-24 1.13e-21 0.549 0.21600 0.5050 3.17e-05 1.81e-22
COLLAGEN CHAIN TRIMERIZATION 39 9.52e-09 3.36e-07 0.543 0.42300 -0.3400 4.80e-06 2.40e-04
ASPARTATE AND ASPARAGINE METABOLISM 10 1.21e-02 5.23e-02 0.542 0.01360 0.5420 9.40e-01 2.99e-03
SHC MEDIATED CASCADE FGFR3 12 6.60e-03 3.20e-02 0.541 0.21400 0.4970 1.98e-01 2.90e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.52e-06 3.63e-05 0.540 -0.21600 0.4950 4.42e-02 3.90e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.77e-04 1.72e-03 0.535 -0.00703 0.5350 9.57e-01 3.43e-05
SELENOAMINO ACID METABOLISM 107 2.87e-19 2.78e-17 0.534 0.33200 0.4180 3.09e-09 7.55e-14
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.13e-02 4.97e-02 0.534 -0.18700 0.5000 3.06e-01 6.19e-03
SCAVENGING BY CLASS A RECEPTORS 13 5.54e-03 2.75e-02 0.532 0.44600 0.2910 5.40e-03 6.91e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 8.63e-03 3.98e-02 0.532 -0.53000 0.0488 2.34e-03 7.79e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.83e-02 6.99e-02 0.530 0.23100 0.4770 2.06e-01 8.98e-03
ACTIVATION OF RAC1 13 3.20e-03 1.84e-02 0.530 -0.49600 0.1850 1.95e-03 2.47e-01
TRIGLYCERIDE CATABOLISM 14 2.55e-03 1.54e-02 0.529 -0.05210 0.5260 7.36e-01 6.55e-04
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 2.65e-03 1.59e-02 0.525 0.19800 0.4870 1.85e-01 1.10e-03
PI 3K CASCADE FGFR3 12 8.60e-03 3.98e-02 0.525 0.18800 0.4910 2.60e-01 3.26e-03
SHC MEDIATED CASCADE FGFR4 10 1.76e-02 6.84e-02 0.524 0.08370 0.5170 6.47e-01 4.65e-03
FRS MEDIATED FGFR3 SIGNALING 14 3.89e-03 2.15e-02 0.523 0.15100 0.5010 3.27e-01 1.18e-03
COMPLEMENT CASCADE 22 2.31e-04 2.17e-03 0.521 0.34400 0.3910 5.24e-03 1.48e-03
FRS MEDIATED FGFR4 SIGNALING 12 7.96e-03 3.74e-02 0.519 0.03200 0.5180 8.48e-01 1.88e-03
CITRIC ACID CYCLE TCA CYCLE 22 1.67e-04 1.69e-03 0.519 0.09520 0.5100 4.40e-01 3.43e-05
CRMPS IN SEMA3A SIGNALING 16 1.82e-03 1.17e-02 0.517 -0.07660 -0.5110 5.96e-01 3.99e-04
NONSENSE MEDIATED DECAY NMD 109 4.07e-18 3.39e-16 0.513 0.35300 0.3720 2.01e-10 1.88e-11
PI 3K CASCADE FGFR4 10 2.03e-02 7.51e-02 0.512 0.05190 0.5100 7.76e-01 5.26e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 5.16e-03 2.64e-02 0.510 -0.12500 0.4950 4.35e-01 2.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 5.93e-04 4.70e-03 0.510 -0.22300 0.4590 1.02e-01 7.54e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.18e-03 8.37e-03 0.509 0.15700 0.4840 2.49e-01 3.73e-04
PLATELET SENSITIZATION BY LDL 15 3.41e-03 1.92e-02 0.505 0.05480 0.5020 7.13e-01 7.57e-04
RHOBTB3 ATPASE CYCLE 10 1.87e-02 7.05e-02 0.505 -0.14100 0.4850 4.40e-01 7.95e-03
GLYCOGEN STORAGE DISEASES 12 1.58e-02 6.32e-02 0.491 0.18600 0.4550 2.66e-01 6.37e-03
SEROTONIN RECEPTORS 10 2.08e-02 7.64e-02 0.491 -0.39300 0.2940 3.13e-02 1.07e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.20e-26 4.68e-24 0.491 0.14000 0.4710 1.59e-03 1.72e-26
DARPP 32 EVENTS 23 1.70e-04 1.70e-03 0.488 -0.20100 0.4450 9.54e-02 2.22e-04
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 4.62e-03 2.45e-02 0.486 0.43700 0.2120 2.46e-03 1.42e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.59e-25 1.05e-22 0.68000 4.43e-01 0.515000 9.24e-13 9.30e-17
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.53e-04 6.42e-03 0.65800 7.89e-02 0.654000 6.50e-01 1.74e-04
MET ACTIVATES RAP1 AND RAC1 11 1.29e-03 8.88e-03 0.61800 -5.67e-01 0.245000 1.12e-03 1.60e-01
COMPLEX I BIOGENESIS 56 1.26e-13 7.33e-12 0.61200 2.95e-01 0.536000 1.33e-04 3.88e-12
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 1.66e-21 2.15e-19 0.60300 3.80e-01 0.468000 1.94e-10 4.37e-15
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.27e-03 1.43e-02 0.60100 3.72e-01 0.472000 2.57e-02 4.65e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 3.87e-23 6.45e-21 0.58800 3.24e-01 0.491000 8.10e-09 2.38e-18
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 3.08e-05 4.27e-04 0.58800 -2.22e-01 0.545000 9.34e-02 3.94e-05
INITIAL TRIGGERING OF COMPLEMENT 10 8.52e-03 3.96e-02 0.58200 4.74e-01 0.337000 9.42e-03 6.49e-02
CD28 DEPENDENT VAV1 PATHWAY 10 4.58e-03 2.45e-02 0.57800 -4.09e-01 0.408000 2.51e-02 2.53e-02
EUKARYOTIC TRANSLATION INITIATION 114 6.39e-23 9.31e-21 0.56500 3.06e-01 0.475000 1.75e-08 1.98e-18
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.44e-03 1.49e-02 0.55700 3.56e-02 0.556000 8.24e-01 5.24e-04
RESPIRATORY ELECTRON TRANSPORT 102 4.13e-20 4.38e-18 0.55300 2.10e-01 0.512000 2.46e-04 3.92e-19
PINK1 PRKN MEDIATED MITOPHAGY 22 6.14e-05 7.38e-04 0.55300 1.88e-01 0.521000 1.27e-01 2.36e-05
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 5.73e-03 2.83e-02 0.55300 3.20e-01 0.451000 5.53e-02 6.81e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 9.83e-12 4.77e-10 0.55100 2.70e-01 0.480000 3.32e-04 1.75e-10
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 4.65e-03 2.45e-02 0.55100 -4.32e-01 0.342000 1.30e-02 4.97e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 4.86e-24 1.13e-21 0.54900 2.16e-01 0.505000 3.17e-05 1.81e-22
COLLAGEN CHAIN TRIMERIZATION 39 9.52e-09 3.36e-07 0.54300 4.23e-01 -0.340000 4.80e-06 2.40e-04
ASPARTATE AND ASPARAGINE METABOLISM 10 1.21e-02 5.23e-02 0.54200 1.36e-02 0.542000 9.40e-01 2.99e-03
SHC MEDIATED CASCADE FGFR3 12 6.60e-03 3.20e-02 0.54100 2.14e-01 0.497000 1.98e-01 2.90e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.52e-06 3.63e-05 0.54000 -2.16e-01 0.495000 4.42e-02 3.90e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.77e-04 1.72e-03 0.53500 -7.03e-03 0.535000 9.57e-01 3.43e-05
SELENOAMINO ACID METABOLISM 107 2.87e-19 2.78e-17 0.53400 3.32e-01 0.418000 3.09e-09 7.55e-14
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.13e-02 4.97e-02 0.53400 -1.87e-01 0.500000 3.06e-01 6.19e-03
SCAVENGING BY CLASS A RECEPTORS 13 5.54e-03 2.75e-02 0.53200 4.46e-01 0.291000 5.40e-03 6.91e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 8.63e-03 3.98e-02 0.53200 -5.30e-01 0.048800 2.34e-03 7.79e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.83e-02 6.99e-02 0.53000 2.31e-01 0.477000 2.06e-01 8.98e-03
ACTIVATION OF RAC1 13 3.20e-03 1.84e-02 0.53000 -4.96e-01 0.185000 1.95e-03 2.47e-01
TRIGLYCERIDE CATABOLISM 14 2.55e-03 1.54e-02 0.52900 -5.21e-02 0.526000 7.36e-01 6.55e-04
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 2.65e-03 1.59e-02 0.52500 1.98e-01 0.487000 1.85e-01 1.10e-03
PI 3K CASCADE FGFR3 12 8.60e-03 3.98e-02 0.52500 1.88e-01 0.491000 2.60e-01 3.26e-03
SHC MEDIATED CASCADE FGFR4 10 1.76e-02 6.84e-02 0.52400 8.37e-02 0.517000 6.47e-01 4.65e-03
FRS MEDIATED FGFR3 SIGNALING 14 3.89e-03 2.15e-02 0.52300 1.51e-01 0.501000 3.27e-01 1.18e-03
COMPLEMENT CASCADE 22 2.31e-04 2.17e-03 0.52100 3.44e-01 0.391000 5.24e-03 1.48e-03
FRS MEDIATED FGFR4 SIGNALING 12 7.96e-03 3.74e-02 0.51900 3.20e-02 0.518000 8.48e-01 1.88e-03
CITRIC ACID CYCLE TCA CYCLE 22 1.67e-04 1.69e-03 0.51900 9.52e-02 0.510000 4.40e-01 3.43e-05
CRMPS IN SEMA3A SIGNALING 16 1.82e-03 1.17e-02 0.51700 -7.66e-02 -0.511000 5.96e-01 3.99e-04
NONSENSE MEDIATED DECAY NMD 109 4.07e-18 3.39e-16 0.51300 3.53e-01 0.372000 2.01e-10 1.88e-11
PI 3K CASCADE FGFR4 10 2.03e-02 7.51e-02 0.51200 5.19e-02 0.510000 7.76e-01 5.26e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 5.16e-03 2.64e-02 0.51000 -1.25e-01 0.495000 4.35e-01 2.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 5.93e-04 4.70e-03 0.51000 -2.23e-01 0.459000 1.02e-01 7.54e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.18e-03 8.37e-03 0.50900 1.57e-01 0.484000 2.49e-01 3.73e-04
PLATELET SENSITIZATION BY LDL 15 3.41e-03 1.92e-02 0.50500 5.48e-02 0.502000 7.13e-01 7.57e-04
RHOBTB3 ATPASE CYCLE 10 1.87e-02 7.05e-02 0.50500 -1.41e-01 0.485000 4.40e-01 7.95e-03
GLYCOGEN STORAGE DISEASES 12 1.58e-02 6.32e-02 0.49100 1.86e-01 0.455000 2.66e-01 6.37e-03
SEROTONIN RECEPTORS 10 2.08e-02 7.64e-02 0.49100 -3.93e-01 0.294000 3.13e-02 1.07e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.20e-26 4.68e-24 0.49100 1.40e-01 0.471000 1.59e-03 1.72e-26
DARPP 32 EVENTS 23 1.70e-04 1.70e-03 0.48800 -2.01e-01 0.445000 9.54e-02 2.22e-04
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 4.62e-03 2.45e-02 0.48600 4.37e-01 0.212000 2.46e-03 1.42e-01
CROSSLINKING OF COLLAGEN FIBRILS 13 7.69e-03 3.65e-02 0.48400 4.07e-01 -0.260000 1.10e-02 1.04e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 3.30e-03 1.89e-02 0.48100 -8.17e-02 0.474000 5.71e-01 1.02e-03
FATTY ACYL COA BIOSYNTHESIS 32 1.80e-05 2.80e-04 0.48000 5.65e-02 0.477000 5.80e-01 3.02e-06
GLYCOGEN SYNTHESIS 14 8.97e-03 4.10e-02 0.48000 1.01e-01 0.469000 5.15e-01 2.38e-03
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.49e-02 6.09e-02 0.47500 4.39e-01 0.182000 6.12e-03 2.56e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 17 3.15e-03 1.83e-02 0.47500 8.47e-03 0.475000 9.52e-01 6.99e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 1.54e-02 6.21e-02 0.47400 1.97e-01 0.431000 2.19e-01 7.08e-03
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.68e-02 6.62e-02 0.47300 2.86e-01 0.377000 7.45e-02 1.87e-02
RAS PROCESSING 23 4.75e-04 3.99e-03 0.47200 2.10e-02 0.471000 8.62e-01 9.20e-05
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 3.97e-02 1.22e-01 0.47000 1.05e-01 0.458000 5.64e-01 1.22e-02
JOSEPHIN DOMAIN DUBS 11 3.41e-02 1.10e-01 0.46800 3.01e-01 0.358000 8.42e-02 3.97e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 7.99e-03 3.74e-02 0.46200 -9.23e-04 0.462000 9.95e-01 1.93e-03
MITOPHAGY 29 1.59e-04 1.65e-03 0.45700 1.49e-01 0.433000 1.65e-01 5.53e-05
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.68e-03 1.09e-02 0.45700 -4.76e-02 0.455000 7.12e-01 4.30e-04
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 5.08e-21 5.93e-19 0.45700 2.67e-01 0.371000 5.61e-09 5.84e-16
FGFR2 LIGAND BINDING AND ACTIVATION 12 2.98e-02 9.99e-02 0.45700 2.82e-01 0.359000 9.10e-02 3.12e-02
ENOS ACTIVATION 11 3.05e-02 1.01e-01 0.45400 -6.88e-02 0.449000 6.93e-01 9.93e-03
PROTEIN METHYLATION 17 5.22e-03 2.64e-02 0.45300 3.21e-03 0.453000 9.82e-01 1.21e-03
CRISTAE FORMATION 31 1.06e-04 1.16e-03 0.45200 1.33e-01 0.432000 2.00e-01 3.18e-05
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.69e-02 6.65e-02 0.45000 4.42e-01 -0.087600 5.81e-03 5.84e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 2.40e-09 9.03e-08 0.44700 3.75e-01 -0.244000 3.27e-07 8.92e-04
TRANSLATION 286 3.64e-35 4.25e-32 0.44600 2.32e-01 0.381000 1.72e-11 1.66e-28
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.35e-02 1.09e-01 0.44400 -1.30e-01 0.425000 4.56e-01 1.47e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 9.54e-03 4.31e-02 0.44200 -1.90e-01 0.399000 2.04e-01 7.41e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 19 5.03e-03 2.62e-02 0.44200 1.79e-01 0.404000 1.77e-01 2.32e-03
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 5.05e-02 1.46e-01 0.44000 -3.10e-01 -0.312000 7.48e-02 7.31e-02
GLYCOGEN METABOLISM 25 1.06e-03 7.76e-03 0.43900 2.03e-01 0.389000 7.88e-02 7.52e-04
MITOCHONDRIAL TRANSLATION 93 1.79e-11 8.04e-10 0.43400 2.20e-01 0.375000 2.46e-04 4.31e-10
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.31e-03 1.89e-02 0.43400 4.33e-01 -0.025800 8.02e-04 8.42e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 5.21e-02 1.49e-01 0.43300 -1.51e-01 0.406000 4.08e-01 2.62e-02
CELLULAR RESPONSE TO STARVATION 145 7.89e-17 5.75e-15 0.42800 2.47e-01 0.349000 2.76e-07 4.31e-13
CTLA4 INHIBITORY SIGNALING 19 4.45e-03 2.39e-02 0.42700 -1.21e-01 0.410000 3.63e-01 1.99e-03
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.60e-02 1.14e-01 0.42600 -3.83e-02 0.425000 8.18e-01 1.09e-02
SIGNAL AMPLIFICATION 30 2.40e-04 2.22e-03 0.42600 -5.22e-02 0.423000 6.21e-01 6.11e-05
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.30e-02 1.28e-01 0.42400 9.64e-02 0.413000 5.63e-01 1.33e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 17 1.36e-02 5.80e-02 0.41600 9.79e-02 0.405000 4.85e-01 3.87e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 3.70e-04 3.19e-03 0.41600 6.68e-02 0.411000 5.20e-01 7.54e-05
METABOLISM OF AMINO ACIDS AND DERIVATIVES 307 6.70e-33 3.91e-30 0.41500 1.85e-01 0.371000 2.49e-08 5.44e-29
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 3.33e-03 1.89e-02 0.41300 -2.32e-02 0.413000 8.51e-01 8.03e-04
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 4.48e-07 1.27e-05 0.41200 8.92e-02 0.402000 2.36e-01 9.03e-08
BRANCHED CHAIN AMINO ACID CATABOLISM 21 4.68e-03 2.46e-02 0.41200 2.37e-03 0.412000 9.85e-01 1.08e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.36e-05 2.23e-04 0.41100 1.35e-01 0.389000 1.14e-01 5.06e-06
ER QUALITY CONTROL COMPARTMENT ERQC 21 4.63e-03 2.45e-02 0.40900 -4.10e-02 0.407000 7.45e-01 1.23e-03
PROCESSING AND ACTIVATION OF SUMO 10 6.77e-02 1.74e-01 0.40900 -2.91e-01 0.287000 1.11e-01 1.16e-01
GAP JUNCTION DEGRADATION 11 6.95e-02 1.77e-01 0.40900 1.13e-01 0.393000 5.16e-01 2.41e-02
METABOLISM OF POLYAMINES 57 9.57e-07 2.37e-05 0.40800 7.73e-02 0.400000 3.13e-01 1.74e-07
CALNEXIN CALRETICULIN CYCLE 26 1.62e-03 1.07e-02 0.40600 1.50e-02 0.406000 8.94e-01 3.40e-04
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 3.06e-06 6.61e-05 0.40300 -5.91e-02 0.399000 4.65e-01 8.51e-07
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 7.91e-02 1.93e-01 0.40200 1.64e-01 0.367000 3.47e-01 3.51e-02
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 2.50e-02 8.66e-02 0.40100 1.51e-01 0.371000 2.95e-01 1.01e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 3.02e-03 1.77e-02 0.39900 -1.97e-02 0.399000 8.68e-01 7.18e-04
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 6.66e-06 1.21e-04 0.39700 1.53e-01 0.366000 5.39e-02 4.05e-06
GLUTATHIONE CONJUGATION 29 1.26e-03 8.70e-03 0.39600 6.64e-02 0.390000 5.36e-01 2.77e-04
PYRUVATE METABOLISM 27 1.24e-03 8.65e-03 0.39500 -1.85e-01 0.348000 9.55e-02 1.73e-03
GLUCONEOGENESIS 27 2.37e-03 1.48e-02 0.39400 1.23e-01 0.374000 2.69e-01 7.63e-04
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 49 6.04e-06 1.15e-04 0.39400 3.57e-01 -0.165000 1.51e-05 4.57e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 24 4.37e-03 2.37e-02 0.39300 8.03e-02 0.385000 4.96e-01 1.09e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 2.73e-04 2.47e-03 0.39300 -2.89e-02 0.392000 7.67e-01 6.07e-05
PEXOPHAGY 11 9.30e-02 2.15e-01 0.39200 3.15e-01 0.233000 7.03e-02 1.81e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 2.44e-02 8.55e-02 0.39100 -3.90e-01 0.024800 6.91e-03 8.64e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 6.17e-06 1.16e-04 0.39000 7.78e-02 0.382000 3.23e-01 1.21e-06
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 4.04e-02 1.23e-01 0.38900 2.09e-01 0.329000 1.61e-01 2.76e-02
METHYLATION 11 9.09e-02 2.12e-01 0.38900 1.25e-01 0.368000 4.73e-01 3.45e-02
TRP CHANNELS 19 1.37e-02 5.83e-02 0.38900 -2.18e-02 -0.388000 8.69e-01 3.41e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.20e-01 2.58e-01 0.38900 -2.39e-01 -0.306000 1.90e-01 9.37e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 9.99e-06 1.66e-04 0.38800 1.24e-01 0.368000 1.18e-01 3.58e-06
GLUTAMATE AND GLUTAMINE METABOLISM 13 6.42e-02 1.69e-01 0.38800 2.98e-01 0.248000 6.24e-02 1.22e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 2.13e-02 7.76e-02 0.38800 -2.05e-01 0.329000 1.56e-01 2.25e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.12e-02 7.76e-02 0.38600 2.71e-02 -0.385000 8.47e-01 5.96e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 2.80e-02 9.64e-02 0.38500 -2.19e-01 0.317000 1.42e-01 3.34e-02
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 5.32e-02 1.50e-01 0.38500 3.83e-01 -0.037800 1.69e-02 8.13e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 7.64e-02 1.89e-01 0.38400 -1.62e-01 0.348000 3.51e-01 4.58e-02
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.65e-02 1.73e-01 0.38300 1.65e-01 0.345000 3.03e-01 3.11e-02
HEDGEHOG LIGAND BIOGENESIS 61 2.85e-06 6.27e-05 0.38200 1.37e-01 0.357000 6.48e-02 1.43e-06
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 7.55e-02 1.88e-01 0.38200 2.42e-01 -0.295000 1.64e-01 8.99e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 4.97e-04 4.08e-03 0.38200 2.74e-02 0.381000 7.79e-01 9.59e-05
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 5.94e-02 1.61e-01 0.38200 2.82e-02 0.381000 8.60e-01 1.75e-02
CS DS DEGRADATION 14 5.77e-02 1.58e-01 0.38100 2.72e-01 0.267000 7.81e-02 8.34e-02
CHAPERONE MEDIATED AUTOPHAGY 20 1.70e-02 6.66e-02 0.38100 2.47e-01 0.291000 5.64e-02 2.44e-02
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 5.15e-03 2.64e-02 0.38100 -1.44e-01 0.353000 2.33e-01 3.40e-03
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 8.18e-02 1.96e-01 0.38000 -1.28e-01 0.358000 4.61e-01 3.98e-02
RHO GTPASES ACTIVATE WASPS AND WAVES 36 2.53e-04 2.30e-03 0.38000 -1.89e-01 0.330000 5.00e-02 6.22e-04
ANCHORING FIBRIL FORMATION 13 4.94e-02 1.44e-01 0.38000 2.21e-01 -0.309000 1.67e-01 5.41e-02
INSULIN RECEPTOR RECYCLING 20 1.14e-02 5.02e-02 0.37900 -1.01e-01 0.365000 4.33e-01 4.73e-03
DEGRADATION OF GLI1 BY THE PROTEASOME 57 7.46e-06 1.28e-04 0.37800 1.07e-01 0.363000 1.64e-01 2.13e-06
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 6.56e-02 1.71e-01 0.37800 -1.74e-01 0.335000 2.97e-01 4.44e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 1.33e-01 2.78e-01 0.37700 -3.34e-01 -0.174000 6.74e-02 3.40e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 11 1.12e-01 2.46e-01 0.37600 3.01e-01 0.226000 8.35e-02 1.95e-01
PYRIMIDINE SALVAGE 10 1.38e-01 2.83e-01 0.37600 -2.86e-01 -0.244000 1.17e-01 1.82e-01
INFLUENZA INFECTION 145 4.85e-13 2.69e-11 0.37400 2.15e-01 0.306000 7.61e-06 2.16e-10
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.44e-02 6.01e-02 0.37300 -3.01e-01 0.219000 2.29e-02 9.78e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 3.54e-06 7.38e-05 0.37000 8.98e-02 0.359000 2.18e-01 8.22e-07
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 9.29e-02 2.15e-01 0.36900 1.01e-01 0.355000 5.45e-01 3.30e-02
SIGNALING BY FGFR4 IN DISEASE 10 1.13e-01 2.48e-01 0.36900 -1.92e-01 0.315000 2.93e-01 8.45e-02
CYTOSOLIC TRNA AMINOACYLATION 24 1.02e-02 4.58e-02 0.36800 3.03e-01 0.210000 1.03e-02 7.53e-02
COLLAGEN FORMATION 77 6.48e-08 2.16e-06 0.36800 3.26e-01 -0.170000 7.50e-07 9.79e-03
PENTOSE PHOSPHATE PATHWAY 13 6.28e-02 1.67e-01 0.36700 -1.44e-01 0.338000 3.69e-01 3.51e-02
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 1.44e-02 6.01e-02 0.36600 3.43e-01 0.128000 5.36e-03 2.98e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 1.00e-02 4.50e-02 0.36500 4.67e-03 0.365000 9.69e-01 2.45e-03
ERYTHROPOIETIN ACTIVATES RAS 13 7.51e-02 1.87e-01 0.36500 1.42e-02 0.364000 9.30e-01 2.29e-02
STABILIZATION OF P53 54 3.31e-05 4.48e-04 0.36400 1.08e-01 0.347000 1.70e-01 1.01e-05
ACTIVATION OF SMO 16 3.38e-02 1.09e-01 0.36400 3.05e-01 -0.198000 3.48e-02 1.70e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.26e-01 2.65e-01 0.36300 1.49e-01 0.332000 3.94e-01 5.69e-02
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 3.42e-02 1.10e-01 0.36200 -3.33e-01 -0.141000 1.44e-02 2.99e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 9.90e-02 2.26e-01 0.36200 5.66e-02 0.357000 7.34e-01 3.22e-02
RHO GTPASES ACTIVATE ROCKS 19 2.96e-02 9.96e-02 0.36200 3.17e-01 0.174000 1.68e-02 1.89e-01
SMOOTH MUSCLE CONTRACTION 33 2.39e-03 1.48e-02 0.36100 2.91e-01 0.213000 3.81e-03 3.40e-02
MITOCHONDRIAL PROTEIN IMPORT 63 7.34e-06 1.28e-04 0.36000 1.00e-01 0.346000 1.68e-01 2.06e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 2.26e-02 8.01e-02 0.35900 2.47e-01 0.260000 4.99e-02 3.90e-02
TRIGLYCERIDE METABOLISM 22 1.32e-02 5.68e-02 0.35900 -3.82e-02 0.357000 7.56e-01 3.77e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 7.95e-02 1.93e-01 0.35800 -1.98e-02 0.358000 9.02e-01 2.55e-02
FERTILIZATION 12 8.88e-02 2.07e-01 0.35700 3.23e-01 -0.152000 5.31e-02 3.62e-01
DEGRADATION OF AXIN 53 6.10e-05 7.38e-04 0.35600 9.68e-02 0.342000 2.23e-01 1.65e-05
IRON UPTAKE AND TRANSPORT 51 4.33e-05 5.55e-04 0.35500 -1.05e-01 0.339000 1.95e-01 2.79e-05
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 4.30e-07 1.25e-05 0.35400 9.76e-03 0.354000 8.82e-01 6.31e-08
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.08e-01 2.41e-01 0.35400 4.51e-02 0.351000 7.87e-01 3.54e-02
FRS MEDIATED FGFR2 SIGNALING 18 3.56e-02 1.13e-01 0.35400 3.91e-02 0.351000 7.74e-01 9.86e-03
RRNA PROCESSING 194 2.61e-15 1.60e-13 0.35300 2.37e-01 0.262000 1.38e-08 3.25e-10
SIGNALING BY ROBO RECEPTORS 205 3.49e-16 2.40e-14 0.35200 1.78e-01 0.304000 1.17e-05 6.74e-14
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.03e-03 2.22e-02 0.35000 2.27e-01 -0.267000 3.78e-02 1.47e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.15e-01 2.51e-01 0.34900 -2.48e-01 0.246000 1.54e-01 1.58e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.35e-02 1.29e-01 0.34900 1.41e-01 0.319000 3.00e-01 1.90e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 3.05e-05 4.27e-04 0.34800 8.59e-02 0.338000 2.54e-01 7.34e-06
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 9.16e-02 2.13e-01 0.34800 1.84e-01 0.295000 2.33e-01 5.61e-02
AGGREPHAGY 35 1.94e-03 1.24e-02 0.34700 3.45e-01 0.042100 4.17e-04 6.67e-01
COLLAGEN DEGRADATION 49 8.75e-05 9.91e-04 0.34700 3.15e-01 -0.146000 1.39e-04 7.64e-02
KILLING MECHANISMS 10 1.53e-01 3.08e-01 0.34600 1.14e-01 -0.327000 5.34e-01 7.38e-02
CGMP EFFECTS 15 7.95e-02 1.93e-01 0.34600 -2.96e-01 -0.179000 4.74e-02 2.31e-01
RECEPTOR MEDIATED MITOPHAGY 11 1.42e-01 2.90e-01 0.34500 2.97e-02 0.344000 8.64e-01 4.83e-02
PROLONGED ERK ACTIVATION EVENTS 14 6.82e-02 1.75e-01 0.34500 -2.53e-01 0.234000 1.01e-01 1.29e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 1.97e-02 7.36e-02 0.34500 -3.26e-01 0.112000 9.64e-03 3.73e-01
PROTEIN UBIQUITINATION 69 2.39e-06 5.36e-05 0.34500 -1.33e-01 0.319000 5.70e-02 4.77e-06
RESPONSE OF MTB TO PHAGOCYTOSIS 21 2.30e-02 8.10e-02 0.34300 -3.63e-02 0.341000 7.74e-01 6.83e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 1.77e-05 2.79e-04 0.34100 1.44e-01 0.309000 4.29e-02 1.38e-05
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 8.67e-07 2.20e-05 0.34100 5.68e-02 0.336000 3.74e-01 1.46e-07
P75NTR SIGNALS VIA NF KB 16 6.74e-02 1.74e-01 0.34100 3.29e-01 0.089300 2.28e-02 5.36e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.47e-02 1.87e-01 0.34000 2.87e-01 -0.182000 6.28e-02 2.38e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 7.36e-03 3.53e-02 0.33900 -3.47e-02 0.337000 7.50e-01 2.01e-03
SEMA4D IN SEMAPHORIN SIGNALING 24 1.65e-02 6.54e-02 0.33900 3.38e-01 0.025600 4.17e-03 8.28e-01
RHOBTB2 GTPASE CYCLE 23 2.35e-02 8.26e-02 0.33900 1.53e-01 0.302000 2.03e-01 1.22e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 5.29e-05 6.49e-04 0.33700 5.22e-02 0.333000 4.88e-01 9.83e-06
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 4.15e-02 1.25e-01 0.33600 -9.78e-02 0.322000 4.72e-01 1.81e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 1.19e-01 2.57e-01 0.33600 3.24e-01 0.089000 4.32e-02 5.79e-01
RHO GTPASES ACTIVATE CIT 18 5.83e-02 1.59e-01 0.33600 2.51e-01 0.223000 6.57e-02 1.01e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 1.63e-01 3.25e-01 0.33600 7.11e-02 0.328000 6.83e-01 5.97e-02
DERMATAN SULFATE BIOSYNTHESIS 11 1.75e-01 3.44e-01 0.33500 1.93e-01 0.274000 2.67e-01 1.15e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.12e-02 1.47e-01 0.33500 3.24e-01 -0.086900 2.09e-02 5.35e-01
ANTIGEN PROCESSING CROSS PRESENTATION 93 2.99e-07 8.94e-06 0.33400 9.31e-02 0.321000 1.21e-01 8.68e-08
CELLULAR RESPONSE TO HYPOXIA 71 9.98e-06 1.66e-04 0.33400 7.94e-02 0.324000 2.48e-01 2.28e-06
REGULATION OF PTEN STABILITY AND ACTIVITY 66 2.22e-05 3.32e-04 0.33300 6.85e-02 0.326000 3.36e-01 4.56e-06
TIGHT JUNCTION INTERACTIONS 18 4.23e-02 1.27e-01 0.33300 -3.05e-01 0.135000 2.53e-02 3.22e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 3.37e-02 1.09e-01 0.33300 7.86e-02 0.323000 5.33e-01 1.03e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 3.02e-03 1.77e-02 0.33200 -7.08e-02 -0.325000 4.62e-01 7.54e-04
MET ACTIVATES PTK2 SIGNALING 29 6.19e-03 3.02e-02 0.33200 2.93e-01 -0.156000 6.37e-03 1.45e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.16e-02 5.07e-02 0.33200 -8.46e-02 0.321000 4.55e-01 4.63e-03
SYNDECAN INTERACTIONS 26 1.82e-02 6.99e-02 0.33200 2.50e-01 0.218000 2.74e-02 5.46e-02
FCERI MEDIATED NF KB ACTIVATION 76 5.14e-06 1.03e-04 0.33100 5.68e-02 0.326000 3.92e-01 9.18e-07
DEGRADATION OF DVL 55 1.94e-04 1.86e-03 0.33000 1.24e-01 0.305000 1.11e-01 8.98e-05
PI 3K CASCADE FGFR2 16 7.77e-02 1.91e-01 0.32900 5.24e-02 0.325000 7.17e-01 2.44e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 1.27e-01 2.69e-01 0.32900 -2.97e-01 0.141000 7.49e-02 3.97e-01
INTERLEUKIN 37 SIGNALING 19 5.50e-02 1.54e-01 0.32800 2.89e-01 0.155000 2.92e-02 2.42e-01
INTERACTION BETWEEN L1 AND ANKYRINS 29 8.52e-03 3.96e-02 0.32800 3.63e-02 -0.326000 7.35e-01 2.38e-03
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 1.63e-01 3.24e-01 0.32700 2.78e-01 0.174000 9.60e-02 2.98e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.98e-02 7.36e-02 0.32700 1.71e-01 0.279000 1.31e-01 1.40e-02
P75NTR RECRUITS SIGNALLING COMPLEXES 13 1.34e-01 2.78e-01 0.32700 3.12e-01 0.097700 5.14e-02 5.42e-01
REGULATION OF IFNG SIGNALING 13 1.10e-01 2.43e-01 0.32700 -2.90e-01 0.150000 6.98e-02 3.49e-01
ELASTIC FIBRE FORMATION 36 4.20e-03 2.30e-02 0.32600 3.00e-01 0.127000 1.83e-03 1.86e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 7.31e-02 1.84e-01 0.32500 -3.14e-01 -0.083500 2.48e-02 5.51e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 2.96e-02 9.96e-02 0.32500 9.46e-02 0.311000 4.32e-01 9.81e-03
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 3.35e-02 1.09e-01 0.32500 -2.32e-01 0.228000 7.29e-02 7.81e-02
INSULIN PROCESSING 24 1.99e-02 7.38e-02 0.32300 -3.09e-01 0.095700 8.89e-03 4.17e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 4.06e-02 1.24e-01 0.32300 6.33e-02 0.316000 6.16e-01 1.21e-02
NCAM1 INTERACTIONS 39 1.46e-03 9.86e-03 0.32300 2.10e-01 -0.245000 2.32e-02 8.14e-03
LDL CLEARANCE 16 8.61e-02 2.03e-01 0.32200 4.74e-02 0.319000 7.43e-01 2.73e-02
PLATELET ADHESION TO EXPOSED COLLAGEN 12 1.70e-01 3.36e-01 0.32200 1.45e-01 0.288000 3.85e-01 8.45e-02
RAB GERANYLGERANYLATION 57 7.48e-05 8.72e-04 0.32200 -2.32e-01 0.224000 2.48e-03 3.52e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 1.89e-01 3.63e-01 0.32100 -2.37e-01 0.217000 1.94e-01 2.35e-01
PHASE II CONJUGATION OF COMPOUNDS 60 9.41e-05 1.05e-03 0.32100 1.07e-02 0.321000 8.86e-01 1.68e-05
PKMTS METHYLATE HISTONE LYSINES 48 5.44e-04 4.43e-03 0.32100 2.38e-02 -0.320000 7.76e-01 1.24e-04
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 1.45e-02 6.01e-02 0.32000 -1.36e-01 0.290000 2.29e-01 1.05e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 2.96e-02 9.96e-02 0.32000 -8.71e-02 0.308000 4.80e-01 1.23e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 8.62e-02 2.03e-01 0.32000 -2.77e-01 0.159000 6.29e-02 2.85e-01
ECM PROTEOGLYCANS 64 3.95e-05 5.14e-04 0.32000 3.10e-01 -0.077000 1.78e-05 2.87e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.78e-02 6.86e-02 0.31800 5.16e-02 0.314000 6.43e-01 4.71e-03
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.53e-02 6.19e-02 0.31800 4.86e-02 0.315000 6.56e-01 3.96e-03
ABC TRANSPORTER DISORDERS 69 4.56e-05 5.71e-04 0.31800 1.09e-01 0.298000 1.17e-01 1.82e-05
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 2.26e-01 3.99e-01 0.31700 -3.15e-01 -0.041100 8.50e-02 8.22e-01
TIE2 SIGNALING 17 7.85e-02 1.91e-01 0.31700 1.78e-02 0.316000 8.99e-01 2.41e-02
G PROTEIN ACTIVATION 22 3.50e-02 1.12e-01 0.31600 -2.61e-02 0.315000 8.32e-01 1.05e-02
MET RECEPTOR RECYCLING 10 2.05e-01 3.82e-01 0.31600 -1.33e-01 0.287000 4.67e-01 1.16e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 3.60e-02 1.14e-01 0.31600 8.63e-02 0.304000 4.74e-01 1.17e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 5.35e-02 1.50e-01 0.31500 -7.03e-02 0.307000 5.96e-01 2.04e-02
NUCLEOBASE BIOSYNTHESIS 15 1.01e-01 2.29e-01 0.31500 -4.62e-02 0.312000 7.57e-01 3.66e-02
PROTEIN LOCALIZATION 156 8.85e-11 3.82e-09 0.31500 -5.27e-03 0.315000 9.10e-01 1.21e-11
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 3.85e-02 1.19e-01 0.31500 1.22e-01 0.290000 3.11e-01 1.61e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 2.34e-03 1.47e-02 0.31400 9.26e-03 0.314000 9.18e-01 5.06e-04
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 1.24e-02 5.38e-02 0.31400 3.18e-02 0.312000 7.63e-01 3.07e-03
INFLAMMASOMES 19 5.73e-02 1.57e-01 0.31400 -3.39e-02 0.312000 7.98e-01 1.86e-02
SULFUR AMINO ACID METABOLISM 22 4.45e-02 1.32e-01 0.31300 1.03e-01 0.296000 4.03e-01 1.62e-02
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 2.32e-01 4.08e-01 0.31300 3.15e-02 0.312000 8.63e-01 8.78e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 7.27e-02 1.84e-01 0.31300 1.63e-01 0.267000 2.18e-01 4.43e-02
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 7.89e-05 9.11e-04 0.31200 3.12e-01 0.010100 1.40e-05 8.88e-01
SIGNALING BY BMP 24 2.48e-02 8.61e-02 0.31000 -1.73e-01 0.258000 1.43e-01 2.89e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 4.91e-02 1.44e-01 0.31000 -1.79e-02 -0.309000 8.87e-01 1.41e-02
PURINE CATABOLISM 16 1.15e-01 2.51e-01 0.31000 1.71e-01 0.258000 2.37e-01 7.36e-02
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.19e-02 5.17e-02 0.30900 -1.70e-01 0.258000 1.14e-01 1.61e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 1.35e-01 2.80e-01 0.30900 7.30e-03 0.309000 9.62e-01 4.56e-02
FATTY ACID METABOLISM 146 1.24e-09 4.97e-08 0.30900 2.95e-02 0.307000 5.39e-01 1.52e-10
IRAK4 DEFICIENCY TLR2 4 12 1.83e-01 3.55e-01 0.30800 2.81e-02 0.307000 8.66e-01 6.54e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 1.41e-01 2.88e-01 0.30800 -1.33e-01 0.278000 4.07e-01 8.27e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 9.99e-03 4.50e-02 0.30800 4.94e-02 0.304000 6.24e-01 2.51e-03
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 1.22e-01 2.59e-01 0.30800 -2.76e-01 0.136000 7.40e-02 3.77e-01
MRNA SPLICING 188 1.22e-11 5.68e-10 0.30700 2.80e-01 0.128000 3.85e-11 2.58e-03
G PROTEIN BETA GAMMA SIGNALLING 30 1.07e-02 4.77e-02 0.30700 -1.73e-01 0.254000 1.01e-01 1.61e-02
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 2.33e-01 4.09e-01 0.30600 2.53e-01 0.173000 1.46e-01 3.22e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 5.15e-07 1.43e-05 0.30600 -5.37e-03 0.306000 9.25e-01 8.27e-08
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 1.38e-02 5.84e-02 0.30500 2.85e-01 0.109000 5.26e-03 2.84e-01
GPVI MEDIATED ACTIVATION CASCADE 31 1.45e-02 6.01e-02 0.30500 5.75e-02 0.300000 5.80e-01 3.87e-03
SIGNALING BY FGFR4 31 1.39e-02 5.84e-02 0.30500 3.26e-02 0.303000 7.53e-01 3.47e-03
BIOLOGICAL OXIDATIONS 123 8.33e-08 2.70e-06 0.30400 9.72e-02 0.288000 6.28e-02 3.51e-08
NEGATIVE REGULATION OF FGFR4 SIGNALING 21 5.56e-02 1.54e-01 0.30400 2.09e-02 0.303000 8.68e-01 1.62e-02
REDUCTION OF CYTOSOLIC CA LEVELS 11 2.26e-01 3.99e-01 0.30300 -2.99e-01 -0.049700 8.59e-02 7.75e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 6.62e-02 1.72e-01 0.30300 1.65e-01 0.254000 1.89e-01 4.42e-02
GAP JUNCTION ASSEMBLY 21 6.76e-02 1.74e-01 0.30200 2.33e-01 0.193000 6.50e-02 1.25e-01
FRS MEDIATED FGFR1 SIGNALING 17 1.01e-01 2.28e-01 0.30200 3.64e-02 0.300000 7.95e-01 3.24e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 1.13e-01 2.48e-01 0.30200 -1.46e-01 0.264000 3.28e-01 7.64e-02
RAP1 SIGNALLING 15 1.12e-01 2.46e-01 0.30200 -2.41e-01 0.181000 1.05e-01 2.25e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 2.25e-01 3.99e-01 0.30200 1.99e-02 0.301000 9.09e-01 8.39e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 1.92e-01 3.66e-01 0.30100 2.07e-01 0.218000 1.96e-01 1.74e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.15e-01 3.92e-01 0.30100 1.52e-01 0.259000 3.60e-01 1.20e-01
RAF ACTIVATION 34 7.98e-03 3.74e-02 0.30000 -1.09e-01 0.280000 2.74e-01 4.71e-03
ANTIMICROBIAL PEPTIDES 13 1.92e-01 3.66e-01 0.30000 1.75e-01 0.244000 2.76e-01 1.27e-01
ORC1 REMOVAL FROM CHROMATIN 67 1.16e-04 1.26e-03 0.30000 7.52e-04 0.300000 9.92e-01 2.17e-05
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 1.77e-02 6.84e-02 0.30000 -6.68e-02 0.292000 5.33e-01 6.49e-03
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 1.67e-04 1.69e-03 0.30000 -1.91e-02 0.299000 7.92e-01 3.55e-05
MRNA SPLICING MINOR PATHWAY 52 1.49e-03 9.98e-03 0.29900 2.16e-01 0.207000 7.12e-03 9.77e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 69 1.26e-04 1.33e-03 0.29900 6.07e-02 0.292000 3.83e-01 2.69e-05
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 2.79e-01 4.56e-01 0.29800 -9.87e-02 -0.281000 5.89e-01 1.24e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 1.83e-01 3.55e-01 0.29700 -2.54e-01 0.154000 1.27e-01 3.55e-01
G1 S DNA DAMAGE CHECKPOINTS 65 2.48e-04 2.27e-03 0.29700 8.54e-02 0.285000 2.34e-01 7.16e-05
GABA RECEPTOR ACTIVATION 52 6.21e-04 4.86e-03 0.29700 -1.96e-01 0.224000 1.46e-02 5.28e-03
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 1.00e-03 7.39e-03 0.29700 -9.93e-02 0.280000 2.24e-01 6.28e-04
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 8.48e-02 2.01e-01 0.29600 7.98e-02 -0.286000 5.58e-01 3.60e-02
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 1.48e-02 6.06e-02 0.29600 7.49e-03 0.296000 9.42e-01 3.72e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 2.15e-02 7.82e-02 0.29600 -6.47e-02 -0.289000 5.40e-01 6.18e-03
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 2.87e-01 4.67e-01 0.29600 -2.68e-01 -0.126000 1.43e-01 4.90e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 1.49e-04 1.56e-03 0.29600 5.98e-02 0.290000 3.90e-01 3.20e-05
CLEC7A DECTIN 1 SIGNALING 94 5.46e-06 1.06e-04 0.29600 3.42e-02 0.294000 5.67e-01 8.76e-07
P75NTR REGULATES AXONOGENESIS 10 2.47e-01 4.22e-01 0.29600 -2.51e-01 0.156000 1.69e-01 3.93e-01
LYSOSOME VESICLE BIOGENESIS 33 1.46e-02 6.05e-02 0.29500 5.03e-02 0.291000 6.17e-01 3.84e-03
SARS COV 2 INFECTION 65 1.76e-04 1.72e-03 0.29500 -4.00e-02 0.292000 5.77e-01 4.67e-05
INTERFERON ALPHA BETA SIGNALING 52 9.58e-04 7.16e-03 0.29500 -2.90e-01 0.053100 3.01e-04 5.08e-01
AQUAPORIN MEDIATED TRANSPORT 40 5.24e-03 2.64e-02 0.29400 -1.83e-02 0.294000 8.41e-01 1.31e-03
DISEASES OF DNA REPAIR 11 2.19e-01 3.93e-01 0.29400 2.54e-01 -0.149000 1.45e-01 3.92e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 60 7.21e-04 5.46e-03 0.29300 1.75e-01 0.235000 1.89e-02 1.64e-03
LGI ADAM INTERACTIONS 14 1.44e-01 2.93e-01 0.29300 1.92e-01 -0.222000 2.15e-01 1.51e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.90e-02 9.86e-02 0.29300 1.33e-01 0.261000 2.17e-01 1.48e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 2.32e-05 3.38e-04 0.29300 2.74e-02 0.292000 6.65e-01 3.86e-06
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 7.68e-03 3.65e-02 0.29300 -4.76e-02 0.289000 6.17e-01 2.38e-03
CELLULAR RESPONSE TO CHEMICAL STRESS 149 1.28e-08 4.38e-07 0.29200 1.03e-01 0.274000 2.95e-02 8.42e-09
TNFR2 NON CANONICAL NF KB PATHWAY 79 6.85e-05 8.07e-04 0.29200 1.16e-01 0.268000 7.57e-02 3.85e-05
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 1.48e-02 6.06e-02 0.29200 -6.40e-02 0.285000 5.31e-01 5.35e-03
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 8.89e-02 2.07e-01 0.29100 -2.66e-01 -0.118000 3.93e-02 3.62e-01
C TYPE LECTIN RECEPTORS CLRS 111 8.61e-07 2.20e-05 0.29100 1.84e-02 0.290000 7.38e-01 1.26e-07
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 5.93e-04 4.70e-03 0.29000 -1.76e-01 0.231000 2.42e-02 3.05e-03
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 2.05e-01 3.82e-01 0.28900 -2.66e-01 0.113000 1.11e-01 4.97e-01
REPRESSION OF WNT TARGET GENES 14 1.93e-01 3.66e-01 0.28900 2.39e-01 0.162000 1.21e-01 2.95e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 2.13e-02 7.76e-02 0.28900 1.89e-01 0.218000 5.98e-02 3.04e-02
REGULATION OF RAS BY GAPS 66 3.31e-04 2.92e-03 0.28800 5.86e-02 0.282000 4.11e-01 7.32e-05
CD28 CO STIMULATION 29 2.19e-02 7.92e-02 0.28800 -2.53e-01 0.137000 1.85e-02 2.01e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 2.87e-02 9.81e-02 0.28800 -1.30e-01 0.256000 2.41e-01 2.11e-02
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 2.59e-01 4.35e-01 0.28700 1.80e-02 0.286000 9.18e-01 1.00e-01
PYROPTOSIS 20 7.97e-02 1.93e-01 0.28700 -4.60e-02 0.283000 7.22e-01 2.85e-02
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 6.24e-02 1.66e-01 0.28700 -2.18e-01 0.186000 8.33e-02 1.41e-01
SHC1 EVENTS IN EGFR SIGNALING 11 2.34e-01 4.09e-01 0.28600 -1.82e-01 0.221000 2.97e-01 2.04e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.09e-01 3.85e-01 0.28600 -2.52e-01 0.136000 1.31e-01 4.15e-01
SIGNALING BY HIPPO 20 7.26e-02 1.84e-01 0.28500 -2.15e-01 0.188000 9.64e-02 1.45e-01
SIGNALING BY FGFR3 34 1.76e-02 6.84e-02 0.28500 6.02e-02 0.279000 5.44e-01 4.93e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 1.42e-01 2.90e-01 0.28500 -1.43e-01 -0.246000 3.08e-01 7.88e-02
PRE NOTCH PROCESSING IN GOLGI 17 1.45e-01 2.94e-01 0.28500 2.20e-01 0.181000 1.17e-01 1.97e-01
RHO GTPASES ACTIVATE KTN1 11 2.74e-01 4.52e-01 0.28400 7.42e-02 0.275000 6.70e-01 1.15e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 1.74e-04 1.72e-03 0.28400 -1.61e-01 0.234000 2.28e-02 9.17e-04
BILE ACID AND BILE SALT METABOLISM 24 6.66e-02 1.73e-01 0.28400 1.87e-01 0.214000 1.13e-01 7.00e-02
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 2.02e-01 3.79e-01 0.28400 -3.05e-02 0.282000 8.49e-01 7.82e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 23 5.17e-02 1.49e-01 0.28300 -1.61e-01 0.233000 1.82e-01 5.28e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 5.48e-02 1.53e-01 0.28300 -1.04e-01 0.263000 3.89e-01 2.89e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 2.03e-05 3.12e-04 0.28300 6.54e-02 0.275000 2.76e-01 4.57e-06
SIGNALING BY RETINOIC ACID 32 1.85e-02 7.04e-02 0.28200 -8.47e-02 0.269000 4.07e-01 8.40e-03
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 11 2.95e-01 4.74e-01 0.28100 2.14e-01 0.183000 2.20e-01 2.93e-01
HYALURONAN UPTAKE AND DEGRADATION 11 2.64e-01 4.39e-01 0.28100 -4.02e-02 0.278000 8.17e-01 1.11e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 5.44e-06 1.06e-04 0.28000 8.18e-02 0.268000 1.44e-01 1.65e-06
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 3.31e-01 5.04e-01 0.28000 -1.42e-01 -0.241000 4.36e-01 1.88e-01
SHC MEDIATED CASCADE FGFR1 15 1.83e-01 3.55e-01 0.27900 7.16e-02 0.270000 6.31e-01 7.06e-02
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 2.43e-01 4.18e-01 0.27900 2.07e-01 0.187000 1.97e-01 2.44e-01
KINESINS 47 3.12e-03 1.82e-02 0.27800 1.21e-01 -0.251000 1.51e-01 2.96e-03
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 2.21e-02 7.94e-02 0.27600 8.07e-02 -0.264000 4.29e-01 9.73e-03
KERATAN SULFATE DEGRADATION 11 3.10e-01 4.82e-01 0.27500 2.10e-01 0.178000 2.28e-01 3.06e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.98e-02 1.93e-01 0.27500 2.65e-01 0.074600 2.78e-02 5.36e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 5.62e-02 1.55e-01 0.27500 -1.16e-01 0.249000 3.25e-01 3.45e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 1.16e-03 8.33e-03 0.27500 8.28e-02 0.262000 2.60e-01 3.59e-04
FC EPSILON RECEPTOR FCERI SIGNALING 123 8.59e-07 2.20e-05 0.27400 -1.33e-02 0.274000 7.99e-01 1.53e-07
SARS COV 1 INFECTION 48 5.21e-03 2.64e-02 0.27400 6.65e-02 0.266000 4.25e-01 1.42e-03
PHASE 0 RAPID DEPOLARISATION 31 3.77e-02 1.18e-01 0.27400 -1.61e-01 -0.222000 1.20e-01 3.25e-02
INTERLEUKIN 1 SIGNALING 95 3.18e-05 4.37e-04 0.27400 6.66e-02 0.266000 2.62e-01 7.54e-06
FORMATION OF APOPTOSOME 10 3.00e-01 4.75e-01 0.27400 -1.55e-01 0.226000 3.95e-01 2.16e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 12 2.75e-01 4.52e-01 0.27300 -9.51e-02 -0.256000 5.68e-01 1.24e-01
BIOTIN TRANSPORT AND METABOLISM 11 3.12e-01 4.83e-01 0.27200 2.49e-01 0.111000 1.53e-01 5.25e-01
INTERLEUKIN 12 SIGNALING 37 1.59e-02 6.34e-02 0.27200 -1.32e-02 0.272000 8.89e-01 4.26e-03
N GLYCAN ANTENNAE ELONGATION 15 1.69e-01 3.34e-01 0.27200 -1.56e-01 0.223000 2.97e-01 1.35e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 1.28e-01 2.69e-01 0.27100 -2.03e-01 -0.180000 1.17e-01 1.64e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 1.50e-02 6.10e-02 0.27100 1.98e-01 0.185000 2.84e-02 4.09e-02
SPHINGOLIPID METABOLISM 79 1.68e-04 1.69e-03 0.27000 -7.27e-03 0.270000 9.11e-01 3.32e-05
PI 3K CASCADE FGFR1 15 2.02e-01 3.79e-01 0.27000 5.03e-02 0.265000 7.36e-01 7.58e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 7.05e-02 1.79e-01 0.26900 5.64e-02 0.263000 6.25e-01 2.27e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 2.54e-01 4.29e-01 0.26900 7.07e-02 0.260000 6.59e-01 1.05e-01
COSTIMULATION BY THE CD28 FAMILY 48 3.80e-03 2.11e-02 0.26900 -1.57e-01 0.219000 6.03e-02 8.73e-03
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 4.14e-02 1.25e-01 0.26900 -8.91e-02 0.254000 4.15e-01 2.00e-02
PYRIMIDINE CATABOLISM 10 3.44e-01 5.17e-01 0.26900 -2.66e-01 -0.038800 1.45e-01 8.32e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 6.99e-02 1.78e-01 0.26800 -1.78e-01 0.200000 1.39e-01 9.63e-02
AMINE LIGAND BINDING RECEPTORS 31 2.88e-02 9.83e-02 0.26800 -2.35e-01 0.130000 2.38e-02 2.12e-01
SIGNALING BY CSF3 G CSF 29 3.80e-02 1.18e-01 0.26700 -1.11e-01 0.243000 3.00e-01 2.38e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.23e-01 2.60e-01 0.26700 -1.96e-01 -0.181000 1.19e-01 1.52e-01
TRANS GOLGI NETWORK VESICLE BUDDING 70 4.65e-04 3.93e-03 0.26700 -5.31e-02 0.261000 4.43e-01 1.57e-04
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 5.42e-02 1.52e-01 0.26600 -1.04e-01 0.245000 3.60e-01 3.04e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 8.66e-02 2.04e-01 0.26600 -9.55e-04 0.266000 9.94e-01 2.74e-02
THE NLRP3 INFLAMMASOME 15 1.84e-01 3.56e-01 0.26500 -1.49e-01 0.220000 3.18e-01 1.41e-01
SIGNALING BY INSULIN RECEPTOR 61 1.24e-03 8.65e-03 0.26500 -7.87e-02 0.253000 2.88e-01 6.33e-04
DNA REPLICATION PRE INITIATION 79 2.13e-04 2.02e-03 0.26500 -3.00e-02 0.263000 6.45e-01 5.25e-05
CYTOPROTECTION BY HMOX1 119 7.13e-06 1.28e-04 0.26500 1.08e-01 0.242000 4.27e-02 5.20e-06
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 2.60e-01 4.36e-01 0.26500 -1.46e-01 0.221000 3.81e-01 1.85e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 3.09e-01 4.81e-01 0.26400 2.17e-01 0.151000 1.94e-01 3.66e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 80 2.75e-04 2.47e-03 0.26400 3.51e-02 0.261000 5.88e-01 5.32e-05
INTERLEUKIN 12 FAMILY SIGNALING 44 1.12e-02 4.95e-02 0.26300 3.46e-02 0.261000 6.91e-01 2.77e-03
HSF1 DEPENDENT TRANSACTIVATION 34 3.03e-02 1.01e-01 0.26300 2.62e-01 0.023400 8.20e-03 8.14e-01
TCR SIGNALING 101 3.97e-05 5.14e-04 0.26200 4.54e-02 0.258000 4.31e-01 7.58e-06
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 1.55e-04 1.62e-03 0.26200 8.00e-02 0.249000 1.93e-01 4.88e-05
PEROXISOMAL LIPID METABOLISM 26 6.51e-02 1.70e-01 0.26200 -3.78e-02 0.259000 7.39e-01 2.23e-02
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.99e-01 4.75e-01 0.26100 -1.82e-01 0.187000 2.96e-01 2.83e-01
SIGNALING BY KIT IN DISEASE 20 1.15e-01 2.51e-01 0.26100 -2.30e-01 0.123000 7.50e-02 3.42e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 7.09e-02 1.80e-01 0.26000 5.29e-03 0.260000 9.63e-01 2.16e-02
NEUTROPHIL DEGRANULATION 383 4.33e-17 3.36e-15 0.26000 2.96e-02 0.259000 3.21e-01 4.24e-18
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 6.52e-02 1.70e-01 0.26000 -5.97e-02 0.253000 5.98e-01 2.54e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 2.22e-02 7.97e-02 0.25900 -2.26e-01 -0.128000 1.35e-02 1.62e-01
CELL CELL JUNCTION ORGANIZATION 50 5.99e-03 2.93e-02 0.25900 -2.58e-01 0.024800 1.60e-03 7.62e-01
SIGNALING BY NOTCH4 83 2.92e-04 2.60e-03 0.25900 4.44e-02 0.255000 4.85e-01 6.01e-05
INWARDLY RECTIFYING K CHANNELS 31 3.90e-02 1.20e-01 0.25800 -8.70e-02 0.243000 4.02e-01 1.92e-02
INTERLEUKIN 10 SIGNALING 17 1.64e-01 3.26e-01 0.25700 -1.86e-01 0.177000 1.85e-01 2.06e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 1.21e-01 2.58e-01 0.25700 -1.43e-01 0.213000 2.67e-01 9.93e-02
DAP12 INTERACTIONS 29 4.84e-02 1.42e-01 0.25600 -1.14e-01 0.230000 2.87e-01 3.24e-02
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 1.02e-01 2.31e-01 0.25600 -1.02e-01 0.235000 4.07e-01 5.67e-02
ARACHIDONIC ACID METABOLISM 40 2.24e-02 7.98e-02 0.25500 5.94e-02 0.248000 5.16e-01 6.57e-03
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 1.12e-01 2.46e-01 0.25500 -1.99e-01 0.159000 1.14e-01 2.08e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 3.56e-01 5.23e-01 0.25400 2.15e-01 -0.136000 2.40e-01 4.57e-01
EARLY PHASE OF HIV LIFE CYCLE 14 2.44e-01 4.18e-01 0.25200 -1.09e-01 0.227000 4.80e-01 1.41e-01
POLO LIKE KINASE MEDIATED EVENTS 13 3.05e-01 4.79e-01 0.25100 2.40e-01 0.075100 1.35e-01 6.39e-01
RMTS METHYLATE HISTONE ARGININES 42 1.82e-02 6.99e-02 0.25100 2.50e-01 -0.015700 5.01e-03 8.61e-01
MET ACTIVATES RAS SIGNALING 10 3.67e-01 5.32e-01 0.25000 -2.10e-01 0.136000 2.50e-01 4.57e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 81 5.58e-04 4.49e-03 0.25000 2.67e-02 0.249000 6.78e-01 1.10e-04
SIGNALING BY ERBB2 ECD MUTANTS 16 2.09e-01 3.85e-01 0.25000 -7.58e-02 0.238000 6.00e-01 9.94e-02
METABOLISM OF COFACTORS 18 1.94e-01 3.68e-01 0.24900 4.86e-02 0.244000 7.21e-01 7.26e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 5.71e-02 1.57e-01 0.24900 -2.22e-01 0.114000 3.90e-02 2.88e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 1.33e-02 5.71e-02 0.24900 2.23e-01 0.111000 6.89e-03 1.80e-01
ATTENUATION PHASE 24 1.12e-01 2.46e-01 0.24900 2.46e-01 0.041600 3.73e-02 7.24e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.12e-01 2.46e-01 0.24900 3.90e-02 -0.246000 7.46e-01 4.12e-02
INTERLEUKIN 1 FAMILY SIGNALING 123 2.12e-05 3.20e-04 0.24800 9.48e-02 0.229000 6.96e-02 1.16e-05
GLUCAGON TYPE LIGAND RECEPTORS 23 1.14e-01 2.49e-01 0.24700 -5.54e-02 0.241000 6.46e-01 4.58e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 2.12e-01 3.87e-01 0.24700 1.23e-01 0.214000 3.66e-01 1.16e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.48e-09 5.74e-08 0.24600 2.29e-01 0.090000 1.31e-09 1.72e-02
MAPK6 MAPK4 SIGNALING 83 7.09e-04 5.44e-03 0.24500 5.56e-02 0.239000 3.82e-01 1.71e-04
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.62e-01 3.23e-01 0.24500 -1.29e-02 0.245000 9.20e-01 5.84e-02
PEROXISOMAL PROTEIN IMPORT 57 4.74e-03 2.48e-02 0.24400 -9.45e-02 0.225000 2.17e-01 3.31e-03
CD28 DEPENDENT PI3K AKT SIGNALING 19 1.91e-01 3.64e-01 0.24300 -2.40e-01 -0.039500 6.99e-02 7.65e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 4.19e-04 3.56e-03 0.24300 -3.38e-02 0.241000 5.88e-01 1.13e-04
LATE ENDOSOMAL MICROAUTOPHAGY 31 7.67e-02 1.89e-01 0.24300 1.83e-01 0.160000 7.82e-02 1.22e-01
COHESIN LOADING ONTO CHROMATIN 10 4.32e-01 5.90e-01 0.24300 1.08e-01 0.217000 5.53e-01 2.34e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 2.10e-01 3.85e-01 0.24300 -6.22e-02 0.235000 6.57e-01 9.41e-02
SIGNALING BY FLT3 FUSION PROTEINS 18 2.18e-01 3.93e-01 0.24300 -2.28e-01 -0.081900 9.35e-02 5.48e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 13 3.42e-01 5.17e-01 0.24200 1.59e-01 0.183000 3.21e-01 2.53e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 225 5.01e-09 1.83e-07 0.24200 4.33e-02 0.238000 2.63e-01 8.07e-10
ERKS ARE INACTIVATED 13 2.97e-01 4.74e-01 0.24200 -1.28e-01 0.205000 4.26e-01 2.00e-01
DAP12 SIGNALING 24 1.07e-01 2.39e-01 0.24100 -1.36e-01 0.199000 2.48e-01 9.12e-02
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 9.77e-02 2.24e-01 0.24100 2.81e-02 0.240000 8.00e-01 3.12e-02
HEDGEHOG ON STATE 82 1.25e-03 8.65e-03 0.24100 1.40e-01 0.196000 2.82e-02 2.13e-03
EPHRIN SIGNALING 19 1.78e-01 3.48e-01 0.24100 -7.92e-02 0.227000 5.50e-01 8.65e-02
METABOLISM OF PORPHYRINS 19 1.79e-01 3.51e-01 0.24000 -7.36e-02 0.229000 5.79e-01 8.43e-02
HEME SIGNALING 44 2.86e-02 9.81e-02 0.24000 -1.49e-01 -0.188000 8.76e-02 3.08e-02
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 4.07e-01 5.64e-01 0.24000 1.12e-01 0.212000 5.20e-01 2.23e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 2.42e-01 4.17e-01 0.23900 -5.32e-02 0.233000 7.12e-01 1.06e-01
S PHASE 153 1.40e-06 3.40e-05 0.23900 -6.02e-02 0.231000 1.99e-01 8.25e-07
HOST INTERACTIONS OF HIV FACTORS 125 2.50e-05 3.60e-04 0.23800 1.06e-03 0.238000 9.84e-01 4.35e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 4.09e-01 5.65e-01 0.23800 2.21e-01 0.087900 2.04e-01 6.14e-01
SIGNALING BY WNT IN CANCER 31 6.04e-02 1.63e-01 0.23800 -1.26e-01 0.202000 2.23e-01 5.20e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 5.12e-02 1.47e-01 0.23700 -1.97e-01 0.133000 5.06e-02 1.88e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 7.42e-02 1.86e-01 0.23700 -1.21e-01 0.204000 2.60e-01 5.75e-02
SELECTIVE AUTOPHAGY 72 3.59e-03 2.00e-02 0.23700 1.74e-01 0.160000 1.05e-02 1.91e-02
PROCESSING OF INTRONLESS PRE MRNAS 19 1.85e-01 3.58e-01 0.23600 2.02e-01 -0.122000 1.28e-01 3.59e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.00e-01 3.77e-01 0.23600 1.57e-01 -0.176000 2.50e-01 1.96e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 2.21e-01 3.96e-01 0.23500 1.91e-01 -0.138000 1.74e-01 3.24e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 4.25e-01 5.82e-01 0.23500 -1.44e-01 -0.186000 4.08e-01 2.86e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 2.07e-02 7.63e-02 0.23500 -1.18e-01 0.204000 1.77e-01 1.95e-02
PLASMA LIPOPROTEIN ASSEMBLY 11 3.78e-01 5.40e-01 0.23400 -1.65e-01 0.167000 3.44e-01 3.38e-01
FOXO MEDIATED TRANSCRIPTION 59 5.86e-03 2.88e-02 0.23400 -1.11e-01 0.206000 1.39e-01 6.25e-03
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.88e-01 3.62e-01 0.23400 -1.48e-01 0.181000 2.64e-01 1.71e-01
METALLOPROTEASE DUBS 25 1.22e-01 2.60e-01 0.23400 -4.14e-02 0.230000 7.20e-01 4.67e-02
REGULATION OF IFNA SIGNALING 12 3.99e-01 5.57e-01 0.23300 -1.96e-01 -0.126000 2.40e-01 4.50e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.54e-02 1.54e-01 0.23200 -2.25e-01 -0.055400 1.79e-02 5.60e-01
REGULATION OF KIT SIGNALING 16 2.88e-01 4.67e-01 0.23200 -2.23e-01 -0.062200 1.22e-01 6.67e-01
MITOTIC TELOPHASE CYTOKINESIS 13 3.74e-01 5.37e-01 0.23200 1.95e-01 0.124000 2.23e-01 4.37e-01
VOLTAGE GATED POTASSIUM CHANNELS 40 5.03e-02 1.46e-01 0.23100 -1.40e-01 -0.183000 1.25e-01 4.50e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.30e-01 5.04e-01 0.23000 -1.68e-01 0.157000 2.94e-01 3.26e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.93e-02 9.94e-02 0.22900 1.73e-01 0.150000 3.81e-02 7.17e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 3.64e-01 5.29e-01 0.22800 -1.74e-02 -0.228000 9.14e-01 1.55e-01
SIGNALING BY NTRK3 TRKC 17 2.42e-01 4.17e-01 0.22800 1.29e-01 -0.188000 3.58e-01 1.79e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 1.81e-03 1.17e-02 0.22800 2.25e-01 -0.038000 5.46e-04 5.59e-01
GABA B RECEPTOR ACTIVATION 39 4.35e-02 1.29e-01 0.22800 -4.73e-02 0.223000 6.10e-01 1.60e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 88 1.65e-03 1.08e-02 0.22800 1.28e-01 0.189000 3.83e-02 2.25e-03
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 6.95e-02 1.77e-01 0.22800 -2.27e-01 0.009320 2.17e-02 9.25e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.76e-01 3.46e-01 0.22700 -1.70e-01 -0.151000 1.49e-01 2.02e-01
INTRAFLAGELLAR TRANSPORT 49 1.91e-02 7.15e-02 0.22700 7.94e-02 -0.212000 3.36e-01 1.01e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 92 1.12e-03 8.10e-03 0.22600 5.57e-02 0.219000 3.56e-01 2.89e-04
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 1.04e-01 2.33e-01 0.22500 2.25e-01 0.016100 3.33e-02 8.78e-01
SIGNALING BY FGFR2 IIIA TM 19 2.49e-01 4.23e-01 0.22500 6.70e-02 0.215000 6.13e-01 1.05e-01
SIGNALING BY FGFR1 43 3.81e-02 1.18e-01 0.22500 1.28e-04 0.225000 9.99e-01 1.08e-02
PARASITE INFECTION 55 1.35e-02 5.76e-02 0.22500 -5.25e-02 0.219000 5.01e-01 5.07e-03
CD209 DC SIGN SIGNALING 18 2.43e-01 4.18e-01 0.22400 -6.93e-02 0.213000 6.11e-01 1.18e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 4.63e-01 6.17e-01 0.22400 -3.45e-02 0.221000 8.50e-01 2.26e-01
RHOBTB GTPASE CYCLE 35 8.57e-02 2.03e-01 0.22300 1.29e-01 0.182000 1.87e-01 6.18e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 3.41e-01 5.16e-01 0.22300 -2.08e-01 -0.080500 1.62e-01 5.89e-01
GLYCOSPHINGOLIPID METABOLISM 38 5.57e-02 1.54e-01 0.22300 -2.51e-02 0.222000 7.89e-01 1.81e-02
DNA DAMAGE BYPASS 46 3.14e-02 1.04e-01 0.22300 -2.23e-01 0.009390 8.94e-03 9.12e-01
RHO GTPASES ACTIVATE PAKS 21 2.32e-01 4.07e-01 0.22300 1.57e-01 0.158000 2.12e-01 2.10e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 4.80e-04 4.00e-03 0.22300 1.46e-01 -0.168000 1.33e-02 4.43e-03
EPHB MEDIATED FORWARD SIGNALING 42 3.63e-02 1.14e-01 0.22300 -1.09e-01 0.194000 2.20e-01 2.97e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 1.34e-01 2.78e-01 0.22200 -2.11e-01 0.070100 6.28e-02 5.36e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 2.29e-02 8.10e-02 0.22200 -3.24e-03 -0.222000 9.68e-01 6.07e-03
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 9.58e-02 2.20e-01 0.22200 -2.19e-01 0.037600 3.53e-02 7.17e-01
IRS MEDIATED SIGNALLING 37 5.83e-02 1.59e-01 0.22100 -6.91e-02 0.210000 4.67e-01 2.68e-02
INNATE IMMUNE SYSTEM 771 9.18e-24 1.78e-21 0.22000 1.85e-02 0.219000 3.85e-01 7.12e-25
HDR THROUGH MMEJ ALT NHEJ 10 4.63e-01 6.17e-01 0.21900 1.83e-01 -0.121000 3.16e-01 5.09e-01
UNWINDING OF DNA 12 4.08e-01 5.65e-01 0.21900 -2.13e-01 0.052800 2.02e-01 7.51e-01
REGULATED PROTEOLYSIS OF P75NTR 12 4.38e-01 5.96e-01 0.21900 7.74e-02 0.205000 6.43e-01 2.20e-01
SIGNALING BY FGFR2 IN DISEASE 36 7.75e-02 1.91e-01 0.21900 1.91e-02 0.218000 8.43e-01 2.37e-02
INTERFERON GAMMA SIGNALING 73 5.35e-03 2.69e-02 0.21800 -2.18e-01 0.009670 1.31e-03 8.86e-01
LYSINE CATABOLISM 11 4.74e-01 6.29e-01 0.21800 2.01e-01 0.084600 2.49e-01 6.27e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 3.39e-01 5.13e-01 0.21800 -2.17e-01 0.017400 1.46e-01 9.07e-01
HDACS DEACETYLATE HISTONES 45 3.26e-02 1.07e-01 0.21700 1.52e-01 -0.156000 7.86e-02 7.03e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 1.20e-01 2.58e-01 0.21700 -1.64e-01 0.142000 1.33e-01 1.93e-01
HEME BIOSYNTHESIS 13 3.74e-01 5.37e-01 0.21700 -1.26e-01 0.177000 4.32e-01 2.70e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 3.93e-05 5.14e-04 0.21700 -5.02e-02 0.211000 3.06e-01 1.67e-05
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 3.24e-01 4.96e-01 0.21700 1.84e-01 -0.115000 2.18e-01 4.40e-01
FCERI MEDIATED MAPK ACTIVATION 28 1.33e-01 2.78e-01 0.21700 -2.84e-02 0.215000 7.95e-01 4.91e-02
PCP CE PATHWAY 90 2.43e-03 1.49e-02 0.21700 8.16e-02 0.201000 1.81e-01 1.01e-03
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 2.60e-01 4.36e-01 0.21700 1.88e-01 -0.108000 1.68e-01 4.29e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 10 5.15e-01 6.63e-01 0.21700 -1.11e-01 -0.186000 5.44e-01 3.09e-01
LONG TERM POTENTIATION 23 2.22e-01 3.98e-01 0.21600 -1.65e-01 -0.140000 1.72e-01 2.46e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 2.05e-01 3.82e-01 0.21600 9.73e-02 0.192000 4.09e-01 1.03e-01
OPIOID SIGNALLING 86 1.95e-03 1.24e-02 0.21500 -7.33e-02 0.202000 2.40e-01 1.18e-03
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.46e-01 6.03e-01 0.21500 5.28e-02 0.208000 7.51e-01 2.11e-01
PROCESSING OF SMDT1 16 3.07e-01 4.80e-01 0.21400 -1.72e-01 0.127000 2.32e-01 3.78e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 3.00e-01 4.75e-01 0.21400 -2.11e-01 0.039600 1.33e-01 7.78e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 59 2.20e-02 7.94e-02 0.21400 -1.90e-01 -0.098300 1.18e-02 1.92e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 4.35e-01 5.92e-01 0.21400 -1.40e-02 0.213000 9.33e-01 2.01e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 3.79e-02 1.18e-01 0.21300 -1.72e-01 0.126000 4.66e-02 1.43e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 7.45e-02 1.86e-01 0.21200 -1.19e-02 0.212000 8.99e-01 2.37e-02
INTERLEUKIN 27 SIGNALING 10 5.31e-01 6.70e-01 0.21200 1.75e-01 0.119000 3.38e-01 5.14e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 5.13e-03 2.64e-02 0.21100 6.04e-02 0.202000 3.45e-01 1.55e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 12 4.51e-01 6.07e-01 0.21100 2.10e-01 0.015500 2.07e-01 9.26e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 34 1.21e-01 2.58e-01 0.21100 1.62e-01 0.135000 1.02e-01 1.74e-01
ADHERENS JUNCTIONS INTERACTIONS 30 1.37e-01 2.82e-01 0.21000 -2.10e-01 -0.007220 4.62e-02 9.45e-01
PLASMA LIPOPROTEIN CLEARANCE 26 1.89e-01 3.63e-01 0.21000 5.75e-02 0.202000 6.12e-01 7.41e-02
INTEGRIN SIGNALING 24 2.23e-01 3.98e-01 0.21000 1.05e-01 0.182000 3.74e-01 1.23e-01
PERK REGULATES GENE EXPRESSION 28 1.55e-01 3.11e-01 0.20900 -1.28e-02 0.209000 9.07e-01 5.55e-02
DISEASES OF IMMUNE SYSTEM 23 2.44e-01 4.19e-01 0.20900 1.49e-01 0.146000 2.15e-01 2.24e-01
REGULATION OF BACH1 ACTIVITY 11 4.78e-01 6.32e-01 0.20800 -4.26e-02 0.204000 8.07e-01 2.42e-01
SIGNALING BY ERYTHROPOIETIN 24 2.23e-01 3.98e-01 0.20800 6.39e-02 0.198000 5.88e-01 9.30e-02
SIALIC ACID METABOLISM 32 1.07e-01 2.41e-01 0.20800 -1.51e-01 0.144000 1.40e-01 1.60e-01
RESOLUTION OF D LOOP STRUCTURES 30 1.60e-01 3.20e-01 0.20800 -1.03e-01 -0.181000 3.31e-01 8.70e-02
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 3.29e-01 5.03e-01 0.20800 -1.44e-01 0.149000 3.18e-01 3.01e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 3.05e-01 4.79e-01 0.20700 5.38e-02 0.200000 6.85e-01 1.31e-01
TRNA AMINOACYLATION 42 7.36e-02 1.85e-01 0.20700 2.01e-01 0.049800 2.46e-02 5.76e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 2.09e-01 3.85e-01 0.20600 1.00e-01 0.180000 3.76e-01 1.12e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 1.37e-01 2.82e-01 0.20600 3.96e-02 0.202000 6.98e-01 4.80e-02
COPII MEDIATED VESICLE TRANSPORT 66 1.15e-02 5.02e-02 0.20600 -1.70e-01 0.116000 1.68e-02 1.04e-01
DNA REPLICATION 121 3.90e-04 3.34e-03 0.20500 -4.17e-02 0.201000 4.28e-01 1.35e-04
CELLULAR HEXOSE TRANSPORT 11 5.21e-01 6.63e-01 0.20500 -1.71e-01 -0.113000 3.25e-01 5.18e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 3.70e-01 5.35e-01 0.20500 -7.61e-02 0.190000 6.10e-01 2.02e-01
SIGNALING BY EGFR IN CANCER 22 2.51e-01 4.26e-01 0.20500 7.54e-03 0.205000 9.51e-01 9.68e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.91e-01 5.51e-01 0.20500 1.15e-01 -0.169000 4.56e-01 2.73e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 3.99e-01 5.57e-01 0.20400 -4.08e-02 -0.200000 7.85e-01 1.79e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 3.73e-01 5.36e-01 0.20400 -1.91e-01 0.073600 2.01e-01 6.22e-01
HSF1 ACTIVATION 26 2.18e-01 3.93e-01 0.20400 1.15e-01 0.169000 3.12e-01 1.36e-01
INTERLEUKIN 7 SIGNALING 20 3.08e-01 4.81e-01 0.20400 -9.90e-02 -0.178000 4.43e-01 1.68e-01
REGULATION OF SIGNALING BY CBL 22 2.63e-01 4.39e-01 0.20400 4.29e-02 0.199000 7.28e-01 1.06e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.93e-01 5.52e-01 0.20400 -1.42e-01 0.146000 3.58e-01 3.44e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.57e-01 5.23e-01 0.20400 4.33e-02 0.199000 7.57e-01 1.56e-01
UCH PROTEINASES 88 5.44e-03 2.72e-02 0.20400 7.19e-02 0.190000 2.44e-01 2.03e-03
MATURATION OF NUCLEOPROTEIN 10 5.59e-01 6.93e-01 0.20400 -1.59e-01 -0.127000 3.85e-01 4.86e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 2.05e-01 3.82e-01 0.20300 2.60e-02 0.202000 8.19e-01 7.53e-02
RHOH GTPASE CYCLE 37 9.56e-02 2.20e-01 0.20300 -3.54e-02 0.200000 7.09e-01 3.54e-02
REGULATED NECROSIS 45 6.19e-02 1.66e-01 0.20200 -1.30e-02 0.201000 8.80e-01 1.94e-02
PLATELET CALCIUM HOMEOSTASIS 25 2.40e-01 4.15e-01 0.20100 -1.71e-01 -0.105000 1.38e-01 3.62e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 2.10e-01 3.85e-01 0.20100 -1.48e-01 0.136000 2.10e-01 2.48e-01
INFECTIOUS DISEASE 727 2.04e-18 1.83e-16 0.20000 4.80e-02 0.194000 2.84e-02 6.32e-19
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 3.61e-02 1.14e-01 0.20000 1.07e-01 0.169000 1.54e-01 2.50e-02
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 5.19e-01 6.63e-01 0.20000 1.22e-02 0.200000 9.44e-01 2.52e-01
METAL ION SLC TRANSPORTERS 24 2.15e-01 3.92e-01 0.20000 -1.20e-01 0.160000 3.09e-01 1.76e-01
KERATAN SULFATE BIOSYNTHESIS 24 2.36e-01 4.11e-01 0.19900 -8.45e-03 0.199000 9.43e-01 9.11e-02
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 2.94e-03 1.74e-02 0.19900 -9.01e-02 0.177000 1.33e-01 3.12e-03
ACYL CHAIN REMODELLING OF PE 16 3.61e-01 5.25e-01 0.19900 -1.27e-01 0.153000 3.80e-01 2.89e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 3.45e-01 5.17e-01 0.19900 -8.36e-02 0.180000 5.51e-01 1.99e-01
PURINE SALVAGE 12 4.91e-01 6.47e-01 0.19900 3.79e-03 0.199000 9.82e-01 2.34e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 5.34e-01 6.70e-01 0.19800 -1.91e-01 -0.054500 2.73e-01 7.54e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 8.72e-03 4.00e-02 0.19800 6.36e-02 0.188000 3.14e-01 2.94e-03
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 2.73e-01 4.51e-01 0.19800 1.85e-01 0.070800 1.24e-01 5.57e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.16e-01 2.52e-01 0.19800 1.64e-01 0.111000 7.59e-02 2.31e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 110 1.40e-03 9.53e-03 0.19800 -2.33e-02 0.197000 6.73e-01 3.67e-04
METABOLISM OF RNA 643 1.58e-15 1.02e-13 0.19800 1.62e-01 0.114000 3.15e-12 1.00e-06
GP1B IX V ACTIVATION SIGNALLING 11 5.04e-01 6.56e-01 0.19800 9.26e-02 -0.175000 5.95e-01 3.16e-01
SPRY REGULATION OF FGF SIGNALING 16 3.84e-01 5.46e-01 0.19700 -2.57e-02 0.196000 8.59e-01 1.75e-01
RHO GTPASES ACTIVATE PKNS 47 6.36e-02 1.68e-01 0.19700 -9.67e-05 0.197000 9.99e-01 1.92e-02
G ALPHA I SIGNALLING EVENTS 193 7.33e-06 1.28e-04 0.19700 -9.72e-02 0.171000 2.00e-02 4.17e-05
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 3.48e-01 5.19e-01 0.19700 1.27e-01 -0.150000 3.64e-01 2.85e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 7.56e-02 1.88e-01 0.19600 5.13e-02 -0.190000 5.61e-01 3.15e-02
NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 4.31e-02 1.28e-01 0.19600 1.95e-01 0.019500 1.22e-02 8.02e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 2.98e-01 4.75e-01 0.19600 1.85e-01 -0.065600 1.52e-01 6.12e-01
LAGGING STRAND SYNTHESIS 20 3.31e-01 5.04e-01 0.19600 6.61e-02 0.184000 6.09e-01 1.53e-01
MUCOPOLYSACCHARIDOSES 11 5.12e-01 6.61e-01 0.19600 -8.01e-02 0.179000 6.46e-01 3.05e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 42 8.48e-02 2.01e-01 0.19600 -2.68e-02 0.194000 7.64e-01 2.97e-02
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 5.51e-03 2.74e-02 0.19600 1.19e-01 -0.155000 5.77e-02 1.35e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX 105 1.64e-03 1.08e-02 0.19500 1.46e-01 -0.129000 9.67e-03 2.21e-02
PROLACTIN RECEPTOR SIGNALING 11 5.26e-01 6.66e-01 0.19500 -2.46e-02 0.194000 8.88e-01 2.66e-01
SYNTHESIS OF PC 25 2.58e-01 4.34e-01 0.19500 8.24e-02 0.177000 4.76e-01 1.26e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 6.36e-02 1.68e-01 0.19500 1.92e-01 -0.034900 2.28e-02 6.79e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 3.44e-01 5.17e-01 0.19400 1.73e-01 0.087200 1.80e-01 5.00e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 8.29e-02 1.98e-01 0.19400 -7.65e-02 0.178000 3.91e-01 4.60e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 5.22e-02 1.49e-01 0.19400 7.28e-02 -0.179000 3.73e-01 2.83e-02
NRAGE SIGNALS DEATH THROUGH JNK 56 3.52e-02 1.12e-01 0.19300 1.19e-01 -0.152000 1.23e-01 4.95e-02
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 7.73e-02 1.91e-01 0.19300 1.06e-01 0.161000 2.01e-01 5.11e-02
PEPTIDE HORMONE METABOLISM 58 3.20e-02 1.05e-01 0.19300 -1.09e-01 0.159000 1.50e-01 3.68e-02
TRANSLESION SYNTHESIS BY POLH 19 3.54e-01 5.23e-01 0.19200 2.77e-02 0.190000 8.34e-01 1.51e-01
HEDGEHOG OFF STATE 106 4.28e-03 2.33e-02 0.19200 1.40e-01 0.131000 1.27e-02 1.95e-02
SARS COV INFECTIONS 139 5.56e-04 4.49e-03 0.19200 3.19e-02 0.189000 5.16e-01 1.17e-04
GENERATION OF SECOND MESSENGER MOLECULES 20 3.45e-01 5.17e-01 0.19200 5.93e-02 0.183000 6.46e-01 1.57e-01
TELOMERE EXTENSION BY TELOMERASE 23 2.61e-01 4.36e-01 0.19200 8.57e-02 -0.172000 4.77e-01 1.54e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.93e-01 4.72e-01 0.19100 1.38e-01 0.133000 2.43e-01 2.61e-01
PHASE 2 PLATEAU PHASE 13 5.00e-01 6.52e-01 0.19100 -4.22e-02 -0.186000 7.92e-01 2.45e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.45e-01 5.17e-01 0.19100 -1.89e-01 0.028900 1.55e-01 8.27e-01
O LINKED GLYCOSYLATION OF MUCINS 40 1.08e-01 2.41e-01 0.19100 -1.89e-01 0.023100 3.85e-02 8.01e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 2.25e-01 3.99e-01 0.19000 -7.96e-02 0.173000 4.82e-01 1.28e-01
INTERFERON SIGNALING 160 1.84e-04 1.77e-03 0.19000 -1.90e-01 -0.001910 3.47e-05 9.67e-01
IRAK1 RECRUITS IKK COMPLEX 14 4.94e-01 6.47e-01 0.19000 1.28e-01 0.140000 4.08e-01 3.64e-01
AUTOPHAGY 138 9.64e-04 7.16e-03 0.18900 9.95e-02 0.161000 4.38e-02 1.09e-03
SIGNALING BY FGFR2 64 4.12e-02 1.25e-01 0.18900 1.24e-01 0.142000 8.60e-02 4.92e-02
NGF STIMULATED TRANSCRIPTION 37 1.20e-01 2.58e-01 0.18900 -1.27e-01 0.139000 1.80e-01 1.43e-01
REGULATION OF FZD BY UBIQUITINATION 19 3.44e-01 5.17e-01 0.18900 -7.09e-02 0.175000 5.93e-01 1.87e-01
SEPARATION OF SISTER CHROMATIDS 164 2.38e-04 2.22e-03 0.18900 5.92e-02 0.179000 1.92e-01 7.76e-05
FGFR2 ALTERNATIVE SPLICING 26 2.37e-01 4.12e-01 0.18800 1.80e-01 -0.055600 1.12e-01 6.24e-01
SODIUM CALCIUM EXCHANGERS 10 5.70e-01 7.02e-01 0.18800 -1.70e-01 0.080100 3.51e-01 6.61e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.53e-02 6.19e-02 0.18800 1.21e-01 0.143000 5.32e-02 2.27e-02
SIGNALING BY ACTIVIN 12 5.20e-01 6.63e-01 0.18800 -1.83e-01 0.041300 2.73e-01 8.04e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 2.97e-01 4.74e-01 0.18800 6.37e-02 0.176000 5.89e-01 1.35e-01
POLYMERASE SWITCHING 14 4.98e-01 6.51e-01 0.18700 9.10e-02 0.164000 5.55e-01 2.88e-01
AURKA ACTIVATION BY TPX2 71 1.91e-02 7.15e-02 0.18700 9.35e-02 -0.162000 1.73e-01 1.82e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 5.79e-01 7.07e-01 0.18700 -1.79e-01 0.052700 3.26e-01 7.73e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 5.72e-01 7.03e-01 0.18700 -1.59e-01 0.098400 3.84e-01 5.90e-01
NEDDYLATION 216 6.45e-06 1.19e-04 0.18700 -1.06e-01 0.154000 7.32e-03 1.00e-04
NCAM SIGNALING FOR NEURITE OUT GROWTH 59 3.79e-02 1.18e-01 0.18700 9.40e-02 -0.161000 2.12e-01 3.23e-02
ENDOGENOUS STEROLS 21 3.50e-01 5.20e-01 0.18700 1.74e-01 0.068000 1.68e-01 5.89e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 5.05e-03 2.62e-02 0.18600 -9.35e-02 0.161000 1.14e-01 6.44e-03
CELLULAR RESPONSES TO EXTERNAL STIMULI 596 6.81e-13 3.61e-11 0.18600 9.70e-02 0.158000 5.65e-05 4.97e-11
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 2.30e-01 4.04e-01 0.18500 -7.51e-02 0.170000 5.00e-01 1.27e-01
PROGRAMMED CELL DEATH 184 8.18e-05 9.35e-04 0.18500 3.62e-03 0.185000 9.33e-01 1.47e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 3.55e-01 5.23e-01 0.18500 -1.63e-01 0.087000 2.17e-01 5.12e-01
MITOTIC METAPHASE AND ANAPHASE 204 4.56e-05 5.71e-04 0.18500 5.18e-02 0.177000 2.03e-01 1.27e-05
RHOQ GTPASE CYCLE 58 6.05e-02 1.63e-01 0.18400 6.65e-02 0.171000 3.81e-01 2.40e-02
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.53e-02 6.19e-02 0.18300 9.93e-02 -0.154000 1.30e-01 1.87e-02
KERATAN SULFATE KERATIN METABOLISM 30 2.24e-01 3.99e-01 0.18300 1.00e-02 0.182000 9.24e-01 8.38e-02
PLATELET AGGREGATION PLUG FORMATION 33 2.12e-01 3.88e-01 0.18300 1.01e-01 0.152000 3.14e-01 1.31e-01
APOPTOSIS 162 3.43e-04 3.00e-03 0.18200 8.91e-03 0.182000 8.45e-01 6.50e-05
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 3.19e-01 4.91e-01 0.18200 -1.82e-01 -0.005250 1.31e-01 9.65e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 2.26e-02 8.01e-02 0.18200 -9.62e-02 0.154000 1.58e-01 2.38e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 5.33e-01 6.70e-01 0.18100 1.03e-01 -0.149000 5.37e-01 3.72e-01
HDMS DEMETHYLATE HISTONES 27 2.84e-01 4.62e-01 0.18100 -7.01e-02 -0.166000 5.29e-01 1.34e-01
G ALPHA Z SIGNALLING EVENTS 45 1.03e-01 2.33e-01 0.18100 -3.75e-02 0.177000 6.64e-01 4.03e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 6.50e-02 1.70e-01 0.18100 -1.22e-01 -0.133000 1.01e-01 7.54e-02
RHOA GTPASE CYCLE 143 1.04e-03 7.66e-03 0.18000 1.80e-01 0.017000 2.12e-04 7.26e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 4.62e-02 1.36e-01 0.18000 -1.32e-01 0.123000 7.96e-02 1.04e-01
HIV INFECTION 221 2.58e-05 3.67e-04 0.18000 1.27e-02 0.180000 7.45e-01 4.30e-06
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 2.76e-01 4.53e-01 0.18000 1.78e-01 -0.023000 1.16e-01 8.39e-01
SIGNALING BY PDGFR IN DISEASE 20 3.56e-01 5.23e-01 0.18000 -9.96e-02 0.149000 4.41e-01 2.47e-01
PROTEIN FOLDING 88 1.85e-02 7.04e-02 0.18000 9.38e-02 0.153000 1.29e-01 1.31e-02
ERBB2 ACTIVATES PTK6 SIGNALING 11 6.10e-01 7.29e-01 0.17900 -1.28e-01 -0.125000 4.61e-01 4.73e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 12 5.57e-01 6.92e-01 0.17900 -1.78e-01 0.013000 2.84e-01 9.38e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 2.26e-01 3.99e-01 0.17900 -1.74e-01 0.042400 1.00e-01 6.88e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 62 5.27e-02 1.50e-01 0.17800 6.83e-03 0.178000 9.26e-01 1.53e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 76 2.50e-02 8.66e-02 0.17800 -2.98e-02 0.175000 6.53e-01 8.26e-03
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 284 7.17e-07 1.94e-05 0.17800 -1.48e-01 0.097800 1.74e-05 4.66e-03
SIGNALING BY INTERLEUKINS 345 1.59e-07 5.00e-06 0.17800 3.33e-02 0.174000 2.90e-01 2.77e-08
DSCAM INTERACTIONS 11 6.11e-01 7.29e-01 0.17700 -7.15e-02 -0.162000 6.81e-01 3.52e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 1.21e-01 2.58e-01 0.17700 -6.45e-02 0.164000 4.64e-01 6.21e-02
PLASMA LIPOPROTEIN REMODELING 15 5.07e-01 6.58e-01 0.17600 -1.71e-01 -0.041100 2.51e-01 7.83e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 4.17e-01 5.73e-01 0.17500 -6.85e-02 0.161000 6.15e-01 2.36e-01
SIGNALING BY MET 75 4.00e-02 1.22e-01 0.17500 1.24e-01 0.124000 6.30e-02 6.41e-02
UB SPECIFIC PROCESSING PROTEASES 166 4.92e-04 4.07e-03 0.17500 -5.14e-03 0.175000 9.09e-01 1.03e-04
EXTRACELLULAR MATRIX ORGANIZATION 239 1.54e-05 2.47e-04 0.17500 1.72e-01 -0.029800 4.80e-06 4.28e-01
CILIUM ASSEMBLY 189 1.18e-04 1.26e-03 0.17300 1.25e-01 -0.120000 3.10e-03 4.48e-03
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 34 1.94e-01 3.68e-01 0.17300 1.29e-01 -0.115000 1.92e-01 2.46e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 5.28e-01 6.67e-01 0.17300 -1.73e-01 0.012900 2.63e-01 9.33e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 6.23e-02 1.66e-01 0.17300 1.62e-01 -0.060400 3.13e-02 4.22e-01
G2 M CHECKPOINTS 133 2.02e-03 1.28e-02 0.17300 -5.50e-02 0.164000 2.74e-01 1.10e-03
RHOG GTPASE CYCLE 73 4.58e-02 1.35e-01 0.17300 7.69e-02 0.155000 2.56e-01 2.25e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 4.70e-01 6.25e-01 0.17200 7.28e-02 -0.156000 6.14e-01 2.79e-01
ERK MAPK TARGETS 22 3.50e-01 5.20e-01 0.17200 -1.41e-01 0.099500 2.53e-01 4.19e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 2.54e-01 4.29e-01 0.17200 9.66e-02 -0.142000 3.68e-01 1.85e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 5.43e-01 6.80e-01 0.17200 -1.49e-01 0.084500 3.51e-01 5.98e-01
BASIGIN INTERACTIONS 22 3.59e-01 5.24e-01 0.17200 -6.82e-02 0.157000 5.80e-01 2.01e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 2.69e-01 4.45e-01 0.17100 1.46e-01 -0.088900 1.80e-01 4.16e-01
ACTIVATION OF BH3 ONLY PROTEINS 28 2.94e-01 4.74e-01 0.17100 -1.71e-01 -0.007830 1.18e-01 9.43e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.69e-01 4.45e-01 0.17100 -1.18e-01 0.123000 2.80e-01 2.58e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 138 2.50e-03 1.52e-02 0.17100 1.97e-03 0.171000 9.68e-01 5.49e-04
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 6.38e-04 4.96e-03 0.17000 4.71e-02 0.163000 2.80e-01 1.79e-04
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 341 1.77e-07 5.43e-06 0.17000 -1.13e-01 0.127000 3.59e-04 5.71e-05
CARGO CONCENTRATION IN THE ER 31 2.39e-01 4.15e-01 0.17000 -1.08e-01 0.131000 2.99e-01 2.08e-01
INTEGRIN CELL SURFACE INTERACTIONS 68 5.05e-02 1.46e-01 0.16900 1.68e-01 -0.022800 1.67e-02 7.45e-01
ACYL CHAIN REMODELLING OF PG 10 6.31e-01 7.43e-01 0.16900 -1.11e-01 0.128000 5.44e-01 4.84e-01
CHROMATIN MODIFYING ENZYMES 217 6.30e-05 7.50e-04 0.16900 6.46e-02 -0.156000 1.02e-01 7.55e-05
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.03e-01 4.77e-01 0.16900 1.09e-01 0.128000 3.00e-01 2.24e-01
LAMININ INTERACTIONS 27 3.05e-01 4.79e-01 0.16800 1.64e-01 -0.038800 1.41e-01 7.27e-01
RA BIOSYNTHESIS PATHWAY 12 5.80e-01 7.07e-01 0.16800 -9.34e-02 0.140000 5.76e-01 4.01e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 3.98e-01 5.57e-01 0.16800 -4.29e-02 0.162000 7.34e-01 1.98e-01
CDC42 GTPASE CYCLE 153 1.16e-03 8.33e-03 0.16800 1.54e-01 -0.065800 9.95e-04 1.61e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 5.15e-01 6.63e-01 0.16700 -1.66e-01 -0.023600 2.51e-01 8.70e-01
O LINKED GLYCOSYLATION 85 3.64e-02 1.14e-01 0.16700 -1.13e-01 -0.123000 7.15e-02 5.02e-02
SIGNALING BY FGFR1 IN DISEASE 32 2.66e-01 4.41e-01 0.16700 1.21e-02 0.166000 9.06e-01 1.04e-01
SIGNALING BY FGFR IN DISEASE 55 1.08e-01 2.41e-01 0.16600 3.36e-02 0.163000 6.67e-01 3.65e-02
METABOLISM OF NUCLEOTIDES 91 1.87e-02 7.05e-02 0.16600 -7.33e-02 0.149000 2.27e-01 1.39e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 3.14e-01 4.85e-01 0.16600 -3.75e-02 0.162000 7.36e-01 1.45e-01
PLATELET HOMEOSTASIS 76 3.46e-02 1.11e-01 0.16600 -1.17e-01 0.118000 7.84e-02 7.54e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 4.35e-01 5.92e-01 0.16600 -1.44e-01 0.082600 2.79e-01 5.33e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 2.42e-01 4.18e-01 0.16600 -1.37e-02 0.165000 8.90e-01 9.61e-02
SIGNALING BY VEGF 102 1.63e-02 6.47e-02 0.16500 1.72e-02 0.164000 7.64e-01 4.13e-03
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 3.10e-01 4.81e-01 0.16500 2.02e-02 0.164000 8.50e-01 1.26e-01
TOLL LIKE RECEPTOR CASCADES 137 3.36e-03 1.90e-02 0.16500 -2.44e-02 0.163000 6.22e-01 9.78e-04
MTORC1 MEDIATED SIGNALLING 24 3.90e-01 5.51e-01 0.16500 5.28e-02 0.156000 6.54e-01 1.85e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 5.81e-01 7.07e-01 0.16500 -7.08e-02 -0.149000 6.47e-01 3.35e-01
FORMATION OF THE CORNIFIED ENVELOPE 28 2.96e-01 4.74e-01 0.16500 1.31e-01 -0.099000 2.29e-01 3.65e-01
KERATINIZATION 28 2.96e-01 4.74e-01 0.16500 1.31e-01 -0.099000 2.29e-01 3.65e-01
AMYLOID FIBER FORMATION 56 9.97e-02 2.27e-01 0.16400 -1.72e-02 0.163000 8.24e-01 3.44e-02
RND3 GTPASE CYCLE 38 2.17e-01 3.93e-01 0.16400 -5.56e-03 -0.164000 9.53e-01 8.05e-02
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.49e-01 4.23e-01 0.16400 -1.12e-01 -0.120000 2.38e-01 2.08e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 178 6.01e-04 4.73e-03 0.16400 -5.47e-02 0.154000 2.09e-01 3.93e-04
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 5.52e-01 6.88e-01 0.16300 1.18e-02 0.163000 9.37e-01 2.76e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 2.24e-01 3.99e-01 0.16300 -1.62e-01 0.013800 8.74e-02 8.84e-01
OTHER SEMAPHORIN INTERACTIONS 19 4.93e-01 6.47e-01 0.16300 -1.06e-01 -0.124000 4.25e-01 3.50e-01
METABOLISM OF CARBOHYDRATES 258 3.68e-05 4.93e-04 0.16200 -1.24e-02 0.162000 7.32e-01 7.78e-06
RHOC GTPASE CYCLE 73 5.22e-02 1.49e-01 0.16200 1.58e-01 -0.036100 1.99e-02 5.94e-01
TP53 REGULATES METABOLIC GENES 84 3.16e-02 1.04e-01 0.16200 -6.22e-02 0.149000 3.24e-01 1.82e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 4.46e-01 6.03e-01 0.16100 2.29e-02 0.160000 8.56e-01 2.05e-01
RUNX3 REGULATES NOTCH SIGNALING 13 6.00e-01 7.21e-01 0.16100 9.31e-03 -0.161000 9.54e-01 3.16e-01
SIGNALING BY ERBB4 57 1.05e-01 2.35e-01 0.16000 -3.43e-02 0.156000 6.54e-01 4.13e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 5.20e-01 6.63e-01 0.16000 -7.58e-02 -0.141000 5.78e-01 3.01e-01
SIGNALING BY HEDGEHOG 141 6.61e-03 3.20e-02 0.16000 1.28e-01 0.095500 8.74e-03 5.04e-02
NUCLEOBASE CATABOLISM 31 2.98e-01 4.75e-01 0.15900 -2.53e-02 0.157000 8.08e-01 1.30e-01
RHOBTB1 GTPASE CYCLE 23 4.42e-01 5.99e-01 0.15900 1.01e-01 0.123000 4.00e-01 3.09e-01
TRANSLESION SYNTHESIS BY POLK 17 5.20e-01 6.63e-01 0.15900 -1.17e-02 0.159000 9.33e-01 2.58e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 4.63e-02 1.36e-01 0.15900 -1.17e-01 0.107000 7.73e-02 1.07e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.18e-01 3.93e-01 0.15900 7.70e-02 -0.139000 4.12e-01 1.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 3.01e-01 4.75e-01 0.15800 1.22e-01 -0.099800 2.46e-01 3.44e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 2.39e-01 4.15e-01 0.15800 9.28e-02 0.127000 3.04e-01 1.58e-01
NEGATIVE REGULATION OF FLT3 14 5.71e-01 7.03e-01 0.15800 1.14e-01 -0.108000 4.59e-01 4.83e-01
SIGNALING BY FGFR 74 7.78e-02 1.91e-01 0.15700 8.24e-02 0.133000 2.21e-01 4.77e-02
INTERLEUKIN 35 SIGNALLING 10 7.06e-01 8.00e-01 0.15600 7.18e-02 0.139000 6.94e-01 4.47e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 5.78e-01 7.07e-01 0.15600 -1.05e-01 0.116000 4.98e-01 4.54e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 1.89e-01 3.63e-01 0.15600 -1.36e-01 0.076500 1.23e-01 3.85e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.55e-01 7.58e-01 0.15500 -7.67e-02 0.135000 6.60e-01 4.38e-01
PREGNENOLONE BIOSYNTHESIS 12 6.53e-01 7.57e-01 0.15500 1.53e-01 0.023600 3.58e-01 8.88e-01
ASPARAGINE N LINKED GLYCOSYLATION 283 2.26e-05 3.34e-04 0.15500 -7.62e-02 0.135000 2.76e-02 9.48e-05
REGULATION OF TNFR1 SIGNALING 34 3.13e-01 4.84e-01 0.15500 1.38e-01 0.070300 1.63e-01 4.78e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 6.16e-01 7.32e-01 0.15500 3.17e-02 -0.152000 8.43e-01 3.43e-01
MICRORNA MIRNA BIOGENESIS 24 3.96e-01 5.55e-01 0.15500 1.18e-01 -0.101000 3.19e-01 3.92e-01
CA2 PATHWAY 56 1.18e-01 2.56e-01 0.15500 -1.37e-01 0.072800 7.70e-02 3.46e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 3.49e-01 5.19e-01 0.15500 1.46e-01 -0.051700 1.82e-01 6.36e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 5.82e-01 7.07e-01 0.15500 -1.54e-01 0.002700 3.00e-01 9.86e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 3.17e-01 4.88e-01 0.15500 1.50e-01 -0.037600 1.49e-01 7.17e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 138 7.57e-03 3.62e-02 0.15400 8.91e-03 0.154000 8.57e-01 1.78e-03
NEGATIVE REGULATION OF MAPK PATHWAY 43 2.01e-01 3.79e-01 0.15400 -4.79e-02 0.147000 5.87e-01 9.62e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 3.46e-01 5.17e-01 0.15400 7.78e-02 -0.133000 4.76e-01 2.23e-01
STIMULI SENSING CHANNELS 74 7.81e-02 1.91e-01 0.15400 -3.80e-02 -0.149000 5.72e-01 2.64e-02
CARNITINE METABOLISM 14 5.88e-01 7.11e-01 0.15300 -1.11e-01 0.106000 4.71e-01 4.93e-01
ADAPTIVE IMMUNE SYSTEM 594 4.52e-10 1.88e-08 0.15300 -7.47e-02 0.134000 1.96e-03 2.82e-08
SIGNALING BY WNT 266 1.02e-04 1.13e-03 0.15300 3.78e-03 0.153000 9.16e-01 1.84e-05
OLFACTORY SIGNALING PATHWAY 23 4.62e-01 6.17e-01 0.15300 5.45e-02 0.143000 6.51e-01 2.36e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 93 3.17e-02 1.04e-01 0.15300 -7.94e-02 0.130000 1.86e-01 2.98e-02
G2 M DNA DAMAGE CHECKPOINT 65 1.00e-01 2.28e-01 0.15300 -1.52e-01 0.011800 3.38e-02 8.70e-01
PECAM1 INTERACTIONS 12 6.63e-01 7.63e-01 0.15300 2.44e-02 0.151000 8.83e-01 3.67e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 2.64e-01 4.39e-01 0.15200 -9.11e-02 0.121000 3.44e-01 2.07e-01
SIGNALING BY PTK6 50 1.90e-01 3.64e-01 0.15200 4.77e-02 0.144000 5.60e-01 7.79e-02
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 43 2.51e-01 4.25e-01 0.15200 -1.11e-01 -0.103000 2.07e-01 2.43e-01
SYNTHESIS OF PE 12 6.67e-01 7.67e-01 0.15200 -2.62e-02 -0.149000 8.75e-01 3.71e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 8.85e-02 2.07e-01 0.15100 -1.46e-01 -0.039100 3.08e-02 5.64e-01
STRIATED MUSCLE CONTRACTION 26 3.85e-01 5.46e-01 0.15100 1.20e-01 -0.092200 2.90e-01 4.16e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 5.10e-01 6.58e-01 0.15100 -1.50e-01 -0.020200 2.47e-01 8.76e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 5.78e-01 7.07e-01 0.15100 1.26e-01 -0.083800 4.00e-01 5.74e-01
SIGNALING BY PDGF 55 1.39e-01 2.84e-01 0.15100 1.39e-01 -0.059900 7.57e-02 4.43e-01
GPCR LIGAND BINDING 259 1.06e-04 1.16e-03 0.15100 -5.51e-02 0.140000 1.28e-01 1.03e-04
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 1.92e-01 3.66e-01 0.15100 1.37e-01 -0.061700 1.07e-01 4.69e-01
EGFR DOWNREGULATION 28 3.60e-01 5.24e-01 0.15100 -1.01e-01 0.112000 3.57e-01 3.05e-01
CA DEPENDENT EVENTS 36 2.75e-01 4.52e-01 0.15000 -1.37e-01 0.061700 1.54e-01 5.22e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 3.23e-01 4.96e-01 0.15000 -5.73e-02 -0.139000 5.57e-01 1.55e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 5.97e-01 7.19e-01 0.15000 5.22e-02 0.140000 7.18e-01 3.31e-01
RND1 GTPASE CYCLE 38 3.04e-01 4.78e-01 0.15000 -1.03e-01 -0.109000 2.73e-01 2.46e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 9.27e-03 4.21e-02 0.14900 -6.95e-02 0.132000 1.67e-01 8.62e-03
SIGNALING BY ERBB2 IN CANCER 25 4.09e-01 5.65e-01 0.14900 -1.01e-01 0.110000 3.83e-01 3.42e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 6.36e-01 7.46e-01 0.14900 3.31e-02 0.145000 8.30e-01 3.47e-01
ASSEMBLY OF THE HIV VIRION 16 6.10e-01 7.29e-01 0.14900 1.00e-01 0.109000 4.87e-01 4.49e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 6.53e-01 7.57e-01 0.14900 -9.41e-02 0.115000 5.73e-01 4.91e-01
DUAL INCISION IN GG NER 40 2.91e-01 4.70e-01 0.14800 9.43e-02 0.115000 3.02e-01 2.10e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 1.73e-01 3.41e-01 0.14800 -1.22e-01 -0.084500 1.13e-01 2.70e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 4.39e-01 5.96e-01 0.14800 -4.68e-02 0.140000 6.92e-01 2.34e-01
SIGNALING BY ERBB2 48 2.07e-01 3.85e-01 0.14700 -5.96e-03 0.147000 9.43e-01 7.77e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 4.04e-01 5.60e-01 0.14700 9.82e-02 -0.110000 3.86e-01 3.33e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 4.68e-01 6.23e-01 0.14700 -1.09e-01 -0.099300 3.47e-01 3.90e-01
ACYL CHAIN REMODELLING OF PS 14 6.40e-01 7.49e-01 0.14700 -1.45e-01 -0.022500 3.47e-01 8.84e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 1.17e-01 2.54e-01 0.14700 -9.10e-02 0.115000 2.16e-01 1.17e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 5.10e-01 6.58e-01 0.14600 -1.37e-01 0.051200 2.89e-01 6.92e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 6.00e-01 7.21e-01 0.14600 -6.91e-02 0.129000 6.43e-01 3.87e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 3.89e-01 5.49e-01 0.14600 -5.34e-02 -0.136000 6.07e-01 1.91e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 4.87e-01 6.43e-01 0.14500 -2.92e-02 0.143000 8.12e-01 2.47e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 2.96e-01 4.74e-01 0.14500 1.38e-01 -0.045300 1.47e-01 6.34e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.89e-01 7.11e-01 0.14400 -1.31e-01 0.061400 3.65e-01 6.70e-01
RNA POLYMERASE I TRANSCRIPTION 67 1.36e-01 2.81e-01 0.14400 1.33e-01 0.055300 5.90e-02 4.34e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 5.05e-01 6.56e-01 0.14400 -3.97e-02 0.139000 7.53e-01 2.71e-01
HS GAG BIOSYNTHESIS 29 3.87e-01 5.49e-01 0.14400 -4.81e-02 0.136000 6.54e-01 2.05e-01
CELL JUNCTION ORGANIZATION 75 8.38e-02 2.00e-01 0.14400 -1.25e-01 0.071300 6.08e-02 2.86e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 2.44e-01 4.18e-01 0.14400 -5.85e-02 0.132000 5.07e-01 1.35e-01
LEISHMANIA INFECTION 193 2.40e-03 1.48e-02 0.14300 -2.26e-02 0.141000 5.89e-01 7.11e-04
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 2.08e-01 3.85e-01 0.14300 3.83e-02 0.138000 6.30e-01 8.30e-02
CHOLESTEROL BIOSYNTHESIS 24 4.55e-01 6.11e-01 0.14300 -9.23e-02 0.109000 4.34e-01 3.55e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 6.39e-02 1.69e-01 0.14300 1.06e-01 -0.095500 9.25e-02 1.30e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 1.58e-01 3.17e-01 0.14300 1.40e-01 0.028200 5.69e-02 7.01e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 6.76e-01 7.74e-01 0.14200 -1.33e-02 -0.142000 9.34e-01 3.77e-01
RHOV GTPASE CYCLE 32 4.02e-01 5.59e-01 0.14200 -6.95e-02 -0.124000 4.96e-01 2.26e-01
SURFACTANT METABOLISM 16 6.23e-01 7.36e-01 0.14200 2.52e-02 0.140000 8.61e-01 3.34e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 4.14e-01 5.70e-01 0.14100 -1.07e-02 0.141000 9.21e-01 1.89e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 90 5.82e-02 1.59e-01 0.14100 -6.26e-02 0.127000 3.05e-01 3.78e-02
RNA POLYMERASE III TRANSCRIPTION 41 2.71e-01 4.47e-01 0.14100 8.28e-02 -0.114000 3.59e-01 2.06e-01
POTENTIAL THERAPEUTICS FOR SARS 76 1.23e-01 2.60e-01 0.14100 1.00e-01 0.098500 1.30e-01 1.38e-01
DNA STRAND ELONGATION 32 3.73e-01 5.36e-01 0.14100 -3.85e-02 0.135000 7.06e-01 1.86e-01
ERBB2 REGULATES CELL MOTILITY 14 6.53e-01 7.57e-01 0.14100 -1.38e-01 0.024300 3.70e-01 8.75e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 17 6.13e-01 7.30e-01 0.14000 -3.12e-02 -0.137000 8.24e-01 3.28e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 4.00e-01 5.58e-01 0.14000 1.36e-01 0.033500 1.82e-01 7.43e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 4.90e-01 6.46e-01 0.14000 -4.59e-03 0.140000 9.69e-01 2.35e-01
HEMOSTASIS 471 1.94e-06 4.53e-05 0.14000 2.94e-02 0.137000 2.77e-01 3.87e-07
CELL CYCLE CHECKPOINTS 241 7.13e-04 5.44e-03 0.14000 -3.47e-02 0.136000 3.55e-01 2.95e-04
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 45 2.92e-01 4.71e-01 0.14000 1.06e-01 0.091500 2.20e-01 2.89e-01
RHOB GTPASE CYCLE 67 1.31e-01 2.75e-01 0.14000 1.35e-01 -0.035400 5.58e-02 6.17e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 4.31e-01 5.88e-01 0.13900 -7.08e-03 -0.139000 9.47e-01 1.94e-01
ZINC TRANSPORTERS 15 6.26e-01 7.38e-01 0.13900 -8.66e-02 0.109000 5.61e-01 4.64e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 15 6.36e-01 7.46e-01 0.13900 -1.35e-01 0.033800 3.65e-01 8.21e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 4.90e-01 6.46e-01 0.13900 7.79e-02 -0.115000 5.18e-01 3.38e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 6.26e-01 7.38e-01 0.13900 -1.39e-01 0.006710 3.37e-01 9.63e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 1.86e-01 3.59e-01 0.13900 -1.20e-01 -0.069700 1.02e-01 3.43e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 2.21e-01 3.96e-01 0.13900 -9.21e-02 0.104000 2.65e-01 2.10e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 6.46e-01 7.53e-01 0.13700 1.35e-01 -0.023300 3.64e-01 8.76e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 1.31e-01 2.75e-01 0.13700 -4.91e-02 0.128000 4.81e-01 6.65e-02
DEADENYLATION OF MRNA 25 4.97e-01 6.50e-01 0.13700 -1.37e-01 -0.004670 2.37e-01 9.68e-01
HCMV EARLY EVENTS 79 9.39e-02 2.16e-01 0.13700 1.07e-01 -0.085300 1.01e-01 1.90e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 5.91e-01 7.13e-01 0.13700 7.26e-02 0.116000 5.74e-01 3.70e-01
RHO GTPASE EFFECTORS 247 1.50e-03 9.98e-03 0.13600 5.10e-02 0.127000 1.69e-01 6.24e-04
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 9.27e-02 2.15e-01 0.13600 -2.60e-02 0.134000 6.83e-01 3.50e-02
RIPK1 MEDIATED REGULATED NECROSIS 25 5.01e-01 6.53e-01 0.13600 1.34e-02 0.136000 9.08e-01 2.40e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 1.53e-01 3.08e-01 0.13600 -1.00e-01 0.092700 1.70e-01 2.04e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.80e-01 7.07e-01 0.13600 -7.95e-02 -0.110000 5.28e-01 3.82e-01
SIGNALING BY EGFR 47 2.77e-01 4.54e-01 0.13600 1.58e-02 0.135000 8.52e-01 1.10e-01
DNA DAMAGE RECOGNITION IN GG NER 38 3.55e-01 5.23e-01 0.13500 1.19e-02 0.135000 8.99e-01 1.50e-01
HIV ELONGATION ARREST AND RECOVERY 32 4.20e-01 5.76e-01 0.13500 1.35e-01 0.012000 1.88e-01 9.07e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 8.03e-02 1.94e-01 0.13500 -6.74e-02 0.117000 2.77e-01 5.94e-02
SIGNALING BY LEPTIN 10 7.50e-01 8.37e-01 0.13500 5.02e-02 -0.125000 7.83e-01 4.93e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 49 2.58e-01 4.34e-01 0.13400 -1.33e-01 0.017100 1.06e-01 8.36e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 1.95e-01 3.68e-01 0.13400 -1.19e-02 -0.134000 8.73e-01 7.06e-02
DEFECTS IN COBALAMIN B12 METABOLISM 12 7.32e-01 8.24e-01 0.13400 3.37e-02 0.129000 8.40e-01 4.38e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 6.84e-01 7.81e-01 0.13400 -8.86e-03 0.133000 9.54e-01 3.88e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 7.63e-01 8.47e-01 0.13300 1.33e-01 -0.006490 4.66e-01 9.72e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 3.36e-01 5.10e-01 0.13300 9.00e-02 0.098000 3.02e-01 2.61e-01
RECYCLING PATHWAY OF L1 40 3.73e-01 5.36e-01 0.13300 8.38e-02 0.103000 3.59e-01 2.61e-01
SIGNALING BY NTRK2 TRKB 24 5.09e-01 6.58e-01 0.13300 -1.13e-01 0.068900 3.36e-01 5.59e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 4.60e-01 6.17e-01 0.13200 -4.63e-02 -0.124000 6.55e-01 2.33e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.21e-01 2.58e-01 0.13200 -4.35e-02 -0.124000 4.89e-01 4.80e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 4.25e-01 5.82e-01 0.13200 1.29e-01 -0.024800 2.06e-01 8.08e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 5.46e-01 6.82e-01 0.13100 7.71e-02 0.106000 5.05e-01 3.58e-01
RND2 GTPASE CYCLE 38 3.73e-01 5.36e-01 0.13100 1.12e-02 -0.130000 9.05e-01 1.65e-01
NERVOUS SYSTEM DEVELOPMENT 546 3.37e-06 7.14e-05 0.13000 9.14e-02 0.093100 2.76e-04 2.12e-04
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 3.88e-01 5.49e-01 0.13000 7.78e-02 -0.104000 4.26e-01 2.87e-01
RESOLUTION OF ABASIC SITES AP SITES 37 3.86e-01 5.48e-01 0.12900 1.28e-01 -0.018800 1.78e-01 8.43e-01
SIGNALING BY SCF KIT 41 3.54e-01 5.23e-01 0.12900 -1.29e-01 0.011600 1.55e-01 8.98e-01
INTERLEUKIN 6 FAMILY SIGNALING 18 6.35e-01 7.46e-01 0.12900 1.28e-01 -0.009540 3.46e-01 9.44e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 37 4.13e-01 5.70e-01 0.12900 4.10e-02 0.122000 6.66e-01 1.99e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 1.39e-01 2.86e-01 0.12900 -1.21e-01 -0.044400 5.71e-02 4.85e-01
DEUBIQUITINATION 240 2.65e-03 1.59e-02 0.12800 -1.22e-02 0.128000 7.46e-01 6.78e-04
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 4.17e-01 5.73e-01 0.12800 6.75e-02 0.109000 4.72e-01 2.47e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 114 6.05e-02 1.63e-01 0.12800 -7.47e-03 0.127000 8.90e-01 1.88e-02
RESOLUTION OF SISTER CHROMATID COHESION 100 1.01e-01 2.28e-01 0.12800 6.24e-02 0.111000 2.81e-01 5.45e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 6.91e-01 7.87e-01 0.12800 1.27e-01 -0.006180 3.93e-01 9.67e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 4.60e-01 6.17e-01 0.12700 -2.53e-02 0.125000 8.08e-01 2.29e-01
SIGNALING BY NUCLEAR RECEPTORS 219 4.45e-03 2.39e-02 0.12600 -4.27e-02 0.119000 2.77e-01 2.51e-03
NETRIN 1 SIGNALING 49 3.37e-01 5.12e-01 0.12600 -9.01e-02 -0.088000 2.76e-01 2.87e-01
MET PROMOTES CELL MOTILITY 39 3.96e-01 5.55e-01 0.12600 1.26e-01 0.003570 1.74e-01 9.69e-01
PHOSPHORYLATION OF THE APC C 17 6.56e-01 7.58e-01 0.12600 -1.18e-01 0.042700 3.99e-01 7.60e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.59e-01 5.24e-01 0.12600 5.51e-02 -0.113000 5.42e-01 2.11e-01
SYNTHESIS OF PA 29 5.24e-01 6.65e-01 0.12500 5.73e-02 0.111000 5.93e-01 2.99e-01
AMINO ACIDS REGULATE MTORC1 51 3.01e-01 4.75e-01 0.12500 8.97e-04 0.125000 9.91e-01 1.22e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.85e-01 8.62e-01 0.12500 -1.23e-01 0.021600 4.99e-01 9.06e-01
PEPTIDE LIGAND BINDING RECEPTORS 101 8.79e-02 2.06e-01 0.12500 -2.42e-02 0.123000 6.75e-01 3.31e-02
NEPHRIN FAMILY INTERACTIONS 22 6.12e-01 7.29e-01 0.12500 1.18e-01 0.039600 3.38e-01 7.48e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 5.96e-01 7.19e-01 0.12400 -6.31e-02 0.107000 6.17e-01 3.96e-01
SIGNAL TRANSDUCTION BY L1 21 6.21e-01 7.34e-01 0.12400 1.97e-02 0.123000 8.76e-01 3.31e-01
GLYCOSAMINOGLYCAN METABOLISM 114 6.21e-02 1.66e-01 0.12400 -5.94e-02 0.109000 2.73e-01 4.48e-02
POST TRANSLATIONAL PROTEIN MODIFICATION 1205 9.82e-13 4.98e-11 0.12400 -8.16e-02 0.093100 2.28e-06 6.88e-08
INTRA GOLGI TRAFFIC 43 3.67e-01 5.32e-01 0.12300 -1.22e-01 0.015600 1.65e-01 8.59e-01
G ALPHA Q SIGNALLING EVENTS 154 3.01e-02 1.01e-01 0.12300 -9.54e-04 0.123000 9.84e-01 8.32e-03
INTRINSIC PATHWAY FOR APOPTOSIS 50 2.96e-01 4.74e-01 0.12300 -7.86e-02 0.094800 3.36e-01 2.46e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 536 4.38e-06 8.96e-05 0.12300 -4.13e-02 0.116000 1.03e-01 4.94e-06
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 175 1.67e-02 6.61e-02 0.12300 -1.18e-01 0.035500 7.35e-03 4.18e-01
RNA POLYMERASE III CHAIN ELONGATION 18 6.49e-01 7.55e-01 0.12300 1.05e-01 -0.063900 4.43e-01 6.39e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 7.93e-01 8.66e-01 0.12200 5.81e-02 0.107000 7.38e-01 5.38e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 7.78e-01 8.58e-01 0.12200 7.13e-02 0.098900 6.69e-01 5.53e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 281 1.42e-03 9.63e-03 0.12200 1.06e-01 -0.060900 2.38e-03 7.94e-02
TRAFFICKING OF AMPA RECEPTORS 31 4.94e-01 6.47e-01 0.12200 1.83e-02 -0.120000 8.60e-01 2.46e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 4.24e-01 5.81e-01 0.12100 1.10e-01 0.049700 2.21e-01 5.82e-01
METABOLISM OF LIPIDS 608 1.98e-06 4.53e-05 0.12100 -1.52e-02 0.120000 5.23e-01 4.95e-07
SIGNALLING TO ERKS 34 4.51e-01 6.07e-01 0.12100 -9.33e-02 0.076700 3.47e-01 4.39e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 2.08e-01 3.85e-01 0.12100 -1.20e-01 0.011500 8.05e-02 8.67e-01
ESR MEDIATED SIGNALING 163 2.46e-02 8.58e-02 0.12000 -6.44e-02 0.101000 1.57e-01 2.64e-02
RHOJ GTPASE CYCLE 54 3.24e-01 4.96e-01 0.11900 1.65e-02 0.118000 8.33e-01 1.34e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 5.68e-01 7.02e-01 0.11900 4.71e-02 0.109000 6.66e-01 3.17e-01
RAC1 GTPASE CYCLE 177 2.69e-02 9.27e-02 0.11900 1.16e-01 0.028000 8.04e-03 5.22e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 6.42e-01 7.49e-01 0.11900 -1.19e-01 -0.001360 3.47e-01 9.91e-01
SIGNALING BY NTRKS 131 5.32e-02 1.50e-01 0.11800 -8.38e-02 0.083500 9.80e-02 9.91e-02
MAPK FAMILY SIGNALING CASCADES 287 3.42e-03 1.92e-02 0.11800 3.68e-02 0.112000 2.85e-01 1.10e-03
FORMATION OF RNA POL II ELONGATION COMPLEX 57 3.03e-01 4.77e-01 0.11700 1.17e-01 -0.009630 1.26e-01 9.00e-01
RORA ACTIVATES GENE EXPRESSION 18 6.88e-01 7.84e-01 0.11700 1.42e-03 -0.117000 9.92e-01 3.88e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.16e-01 7.32e-01 0.11700 1.01e-01 0.059900 3.84e-01 6.04e-01
TBC RABGAPS 43 4.01e-01 5.58e-01 0.11700 -2.67e-02 0.114000 7.62e-01 1.96e-01
INTERLEUKIN 15 SIGNALING 12 7.86e-01 8.62e-01 0.11600 -1.15e-01 -0.015900 4.89e-01 9.24e-01
METABOLISM OF FOLATE AND PTERINES 15 7.47e-01 8.36e-01 0.11600 1.08e-01 0.043900 4.70e-01 7.69e-01
PTEN REGULATION 134 8.11e-02 1.95e-01 0.11600 7.97e-02 0.084400 1.12e-01 9.19e-02
EPH EPHRIN SIGNALING 90 1.52e-01 3.08e-01 0.11600 -3.37e-02 0.111000 5.80e-01 6.93e-02
INTEGRATION OF ENERGY METABOLISM 98 1.50e-01 3.03e-01 0.11500 2.30e-02 0.113000 6.94e-01 5.33e-02
SIGNALING BY NODAL 15 7.43e-01 8.32e-01 0.11500 8.23e-03 0.115000 9.56e-01 4.41e-01
TNF SIGNALING 43 4.51e-01 6.07e-01 0.11500 8.34e-02 0.079400 3.44e-01 3.68e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 3.29e-01 5.03e-01 0.11500 -5.36e-02 0.102000 5.00e-01 2.01e-01
FANCONI ANEMIA PATHWAY 36 4.74e-01 6.29e-01 0.11400 4.84e-02 -0.104000 6.15e-01 2.82e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 5.32e-01 6.70e-01 0.11400 -3.08e-02 0.110000 7.66e-01 2.89e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 169 3.09e-02 1.03e-01 0.11400 -7.02e-02 0.089400 1.16e-01 4.52e-02
TRANSPORT OF SMALL MOLECULES 565 1.53e-05 2.47e-04 0.11300 -4.12e-02 0.106000 9.53e-02 1.90e-05
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 2.85e-01 4.63e-01 0.11300 -2.78e-02 0.110000 7.03e-01 1.31e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 7.92e-01 8.66e-01 0.11300 7.74e-02 0.082300 6.29e-01 6.07e-01
SLC TRANSPORTER DISORDERS 69 2.51e-01 4.25e-01 0.11300 -1.05e-01 0.041200 1.31e-01 5.55e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 1.59e-01 3.18e-01 0.11300 -3.38e-02 0.107000 5.74e-01 7.35e-02
CHONDROITIN SULFATE BIOSYNTHESIS 19 6.80e-01 7.76e-01 0.11300 -6.52e-02 0.091700 6.23e-01 4.89e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.29e-01 4.04e-01 0.11200 -6.25e-03 0.112000 9.24e-01 8.86e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 10 8.34e-01 8.99e-01 0.11200 3.89e-02 0.105000 8.31e-01 5.64e-01
G PROTEIN MEDIATED EVENTS 52 3.53e-01 5.23e-01 0.11200 -6.21e-02 0.093100 4.39e-01 2.45e-01
SEMAPHORIN INTERACTIONS 64 2.78e-01 4.55e-01 0.11200 9.38e-02 -0.061100 1.95e-01 3.98e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 7.75e-01 8.55e-01 0.11200 2.84e-02 0.108000 8.54e-01 4.83e-01
NUCLEAR ENVELOPE NE REASSEMBLY 63 3.33e-01 5.06e-01 0.11200 7.48e-02 0.083000 3.05e-01 2.55e-01
TRNA PROCESSING 105 1.31e-01 2.75e-01 0.11200 3.27e-02 -0.107000 5.62e-01 5.92e-02
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 5.33e-01 6.70e-01 0.11100 -2.98e-03 -0.111000 9.76e-01 2.63e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 7.79e-01 8.58e-01 0.11100 1.08e-01 -0.027100 5.01e-01 8.66e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 7.37e-01 8.27e-01 0.11000 6.29e-02 0.089900 6.44e-01 5.09e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 1.80e-01 3.52e-01 0.10900 -4.32e-02 0.100000 4.77e-01 9.79e-02
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 8.36e-01 9.00e-01 0.10900 1.70e-03 0.109000 9.93e-01 5.50e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 4.62e-01 6.17e-01 0.10900 -1.04e-01 -0.033500 2.29e-01 6.98e-01
BASE EXCISION REPAIR 56 3.60e-01 5.24e-01 0.10900 1.07e-01 -0.020500 1.66e-01 7.91e-01
SENSORY PROCESSING OF SOUND 61 3.48e-01 5.19e-01 0.10900 1.07e-01 0.021200 1.50e-01 7.75e-01
RHOU GTPASE CYCLE 33 5.70e-01 7.02e-01 0.10800 -1.05e-01 -0.026800 2.97e-01 7.90e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 5.84e-01 7.08e-01 0.10800 -8.05e-02 -0.071900 4.23e-01 4.75e-01
NICOTINAMIDE SALVAGING 15 7.57e-01 8.41e-01 0.10800 9.13e-02 -0.057400 5.41e-01 7.01e-01
POTASSIUM CHANNELS 90 2.18e-01 3.93e-01 0.10800 -1.06e-01 -0.021900 8.37e-02 7.20e-01
RAC2 GTPASE CYCLE 86 2.47e-01 4.22e-01 0.10700 4.55e-02 0.096800 4.66e-01 1.21e-01
GLUCOSE METABOLISM 80 2.62e-01 4.37e-01 0.10700 1.35e-02 0.106000 8.35e-01 1.02e-01
MITOTIC PROPHASE 92 1.96e-01 3.70e-01 0.10500 -8.97e-02 0.055400 1.37e-01 3.59e-01
NUCLEOTIDE EXCISION REPAIR 109 1.54e-01 3.10e-01 0.10500 -2.74e-02 0.102000 6.21e-01 6.72e-02
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 5.19e-01 6.63e-01 0.10500 -4.44e-02 -0.094800 6.18e-01 2.88e-01
DUAL INCISION IN TC NER 64 3.48e-01 5.19e-01 0.10400 -5.09e-03 0.104000 9.44e-01 1.49e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 6.09e-01 7.29e-01 0.10400 7.00e-02 0.076300 4.86e-01 4.48e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 2.11e-01 3.85e-01 0.10400 -4.45e-02 0.093500 4.61e-01 1.21e-01
MITOTIC G2 G2 M PHASES 184 6.31e-02 1.68e-01 0.10300 9.02e-02 0.050700 3.50e-02 2.36e-01
RHO GTPASES ACTIVATE FORMINS 118 1.68e-01 3.32e-01 0.10300 4.19e-02 0.094400 4.32e-01 7.69e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS 20 7.25e-01 8.18e-01 0.10300 -1.03e-01 0.002700 4.25e-01 9.83e-01
MEIOTIC SYNAPSIS 39 5.25e-01 6.66e-01 0.10200 9.62e-02 -0.035300 2.98e-01 7.03e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 6.17e-01 7.32e-01 0.10200 -7.04e-02 0.073500 5.12e-01 4.94e-01
FLT3 SIGNALING 36 5.69e-01 7.02e-01 0.10100 -1.01e-01 0.008880 2.94e-01 9.27e-01
RAB REGULATION OF TRAFFICKING 118 1.48e-01 3.01e-01 0.10100 -4.09e-02 0.092800 4.43e-01 8.21e-02
REGULATION OF PTEN GENE TRANSCRIPTION 59 3.81e-01 5.42e-01 0.10100 7.85e-02 -0.063600 2.97e-01 3.99e-01
HIV TRANSCRIPTION INITIATION 45 4.93e-01 6.47e-01 0.10100 -1.93e-02 0.099100 8.23e-01 2.50e-01
CELL CELL COMMUNICATION 107 1.81e-01 3.53e-01 0.09990 -7.82e-02 0.062300 1.63e-01 2.66e-01
NUCLEAR IMPORT OF REV PROTEIN 32 6.34e-01 7.46e-01 0.09990 -4.22e-02 -0.090600 6.80e-01 3.75e-01
SIGNALING BY GPCR 476 6.47e-04 4.99e-03 0.09990 -4.44e-02 0.089500 9.79e-02 8.60e-04
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 3.09e-01 4.81e-01 0.09970 8.29e-02 -0.055300 2.18e-01 4.11e-01
MITOTIC SPINDLE CHECKPOINT 96 2.34e-01 4.09e-01 0.09960 -1.33e-02 0.098700 8.22e-01 9.50e-02
MEIOTIC RECOMBINATION 38 5.62e-01 6.96e-01 0.09900 -9.68e-02 0.020900 3.02e-01 8.24e-01
EFFECTS OF PIP2 HYDROLYSIS 27 6.62e-01 7.62e-01 0.09840 3.76e-02 -0.091000 7.35e-01 4.13e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 7.15e-01 8.10e-01 0.09830 -1.28e-03 0.098300 9.92e-01 4.14e-01
REGULATION OF INSULIN SECRETION 71 3.55e-01 5.23e-01 0.09820 -6.27e-03 0.098000 9.27e-01 1.54e-01
METABOLISM OF STEROIDS 111 2.10e-01 3.85e-01 0.09760 8.73e-03 0.097200 8.74e-01 7.71e-02
NEUROTRANSMITTER RELEASE CYCLE 48 5.19e-01 6.63e-01 0.09720 2.79e-02 0.093200 7.38e-01 2.64e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 6.32e-01 7.44e-01 0.09710 9.60e-02 0.014700 3.40e-01 8.84e-01
INTERLEUKIN 17 SIGNALING 66 3.78e-01 5.40e-01 0.09700 -9.12e-02 0.032900 2.00e-01 6.44e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 8.64e-01 9.15e-01 0.09630 -3.98e-02 -0.087700 8.19e-01 6.14e-01
INOSITOL PHOSPHATE METABOLISM 47 5.45e-01 6.82e-01 0.09610 6.27e-02 0.072800 4.57e-01 3.88e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 8.41e-01 9.02e-01 0.09610 3.22e-02 0.090500 8.41e-01 5.72e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 8.04e-01 8.74e-01 0.09600 8.83e-02 -0.037600 5.54e-01 8.01e-01
DEVELOPMENTAL BIOLOGY 809 5.10e-05 6.33e-04 0.09570 6.94e-02 0.065900 8.60e-04 1.54e-03
MEMBRANE TRAFFICKING 579 3.49e-04 3.04e-03 0.09490 -3.63e-02 0.087700 1.37e-01 3.31e-04
DISEASES OF METABOLISM 198 8.43e-02 2.01e-01 0.09480 7.69e-02 0.055300 6.23e-02 1.80e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.29e-01 8.95e-01 0.09440 5.90e-02 0.073700 6.93e-01 6.21e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 3.60e-01 5.24e-01 0.09430 -8.73e-02 0.035600 1.97e-01 5.99e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 5.88e-01 7.11e-01 0.09360 1.20e-02 0.092800 8.94e-01 3.04e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.05e-01 8.74e-01 0.09340 2.32e-02 -0.090500 8.72e-01 5.31e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 365 9.04e-03 4.12e-02 0.09320 -5.08e-03 0.093000 8.68e-01 2.33e-03
SIGNALING BY NOTCH2 33 6.70e-01 7.69e-01 0.09310 -6.89e-02 -0.062600 4.93e-01 5.34e-01
MYOGENESIS 25 7.38e-01 8.27e-01 0.09270 -4.59e-02 -0.080600 6.91e-01 4.86e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 235 4.13e-02 1.25e-01 0.09260 -7.73e-02 0.051000 4.16e-02 1.79e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 4.18e-01 5.74e-01 0.09260 1.90e-02 -0.090600 7.89e-01 2.03e-01
NUCLEOTIDE SALVAGE 21 7.74e-01 8.55e-01 0.09170 -8.76e-02 -0.027200 4.87e-01 8.29e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 6.45e-01 7.52e-01 0.09160 -7.85e-02 -0.047200 4.09e-01 6.19e-01
SIGNALLING TO RAS 20 7.64e-01 8.47e-01 0.09140 6.64e-02 -0.062900 6.07e-01 6.26e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 4.91e-01 6.46e-01 0.09090 4.74e-02 -0.077600 5.47e-01 3.24e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 7.49e-01 8.37e-01 0.09000 -2.00e-02 0.087700 8.68e-01 4.67e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 2.65e-01 4.40e-01 0.08990 7.30e-02 -0.052500 2.01e-01 3.58e-01
APOPTOTIC EXECUTION PHASE 45 5.63e-01 6.97e-01 0.08970 -4.12e-02 0.079700 6.33e-01 3.55e-01
GENE SILENCING BY RNA 83 3.79e-01 5.40e-01 0.08940 -1.47e-02 -0.088100 8.17e-01 1.65e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 7.27e-01 8.18e-01 0.08930 3.32e-02 0.082900 7.61e-01 4.48e-01
OXIDATIVE STRESS INDUCED SENESCENCE 78 3.79e-01 5.40e-01 0.08900 3.33e-02 -0.082500 6.11e-01 2.08e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 6.60e-01 7.62e-01 0.08860 -8.75e-02 -0.014500 3.64e-01 8.81e-01
MITOCHONDRIAL BIOGENESIS 92 3.68e-01 5.33e-01 0.08820 6.35e-02 0.061200 2.93e-01 3.11e-01
CARDIAC CONDUCTION 108 3.06e-01 4.79e-01 0.08820 -7.79e-02 -0.041200 1.62e-01 4.60e-01
HS GAG DEGRADATION 20 7.96e-01 8.69e-01 0.08780 -1.13e-02 -0.087000 9.30e-01 5.01e-01
HIV LIFE CYCLE 143 2.08e-01 3.85e-01 0.08760 2.85e-02 0.082800 5.56e-01 8.77e-02
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 3.15e-01 4.86e-01 0.08760 -4.28e-02 -0.076400 4.45e-01 1.73e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 8.74e-01 9.23e-01 0.08710 -8.62e-02 -0.012300 6.05e-01 9.41e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 5.82e-01 7.07e-01 0.08650 1.12e-02 0.085800 8.92e-01 2.99e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 463 7.14e-03 3.44e-02 0.08650 1.68e-02 0.084800 5.36e-01 1.82e-03
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 7.86e-01 8.62e-01 0.08650 5.96e-02 -0.062700 6.45e-01 6.28e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 6.12e-01 7.29e-01 0.08630 6.95e-02 0.051300 4.10e-01 5.43e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 6.94e-01 7.89e-01 0.08610 4.65e-02 0.072500 6.34e-01 4.58e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 7.96e-01 8.69e-01 0.08610 8.51e-02 -0.013400 5.10e-01 9.17e-01
HATS ACETYLATE HISTONES 91 3.81e-01 5.42e-01 0.08600 -2.86e-02 -0.081100 6.38e-01 1.81e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 5.73e-01 7.03e-01 0.08570 -3.49e-02 0.078300 6.76e-01 3.48e-01
VESICLE MEDIATED TRANSPORT 607 1.23e-03 8.65e-03 0.08560 -2.37e-02 0.082300 3.21e-01 5.67e-04
TRANSCRIPTION OF THE HIV GENOME 67 5.09e-01 6.58e-01 0.08480 5.03e-02 0.068300 4.77e-01 3.34e-01
NICOTINATE METABOLISM 24 7.59e-01 8.43e-01 0.08470 7.15e-02 -0.045400 5.44e-01 7.00e-01
METABOLISM OF VITAMINS AND COFACTORS 148 2.22e-01 3.98e-01 0.08440 3.01e-02 0.078900 5.28e-01 9.79e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 8.92e-01 9.32e-01 0.08430 5.38e-02 -0.064900 7.68e-01 7.22e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 5.28e-01 6.67e-01 0.08380 1.74e-02 -0.081900 8.17e-01 2.77e-01
THE PHOTOTRANSDUCTION CASCADE 20 7.98e-01 8.70e-01 0.08370 -6.13e-02 0.057000 6.35e-01 6.59e-01
DNA REPAIR 291 5.95e-02 1.61e-01 0.08370 -4.80e-02 -0.068500 1.59e-01 4.47e-02
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 2.85e-03 1.70e-02 0.08310 6.04e-02 0.057100 1.01e-02 1.51e-02
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 61 5.09e-01 6.58e-01 0.08310 -6.41e-02 0.052900 3.87e-01 4.75e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 7.52e-01 8.38e-01 0.08300 -1.01e-02 0.082400 9.28e-01 4.59e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 3.57e-01 5.23e-01 0.08260 7.05e-02 -0.042900 2.35e-01 4.70e-01
M PHASE 336 4.19e-02 1.26e-01 0.08200 3.15e-02 0.075700 3.23e-01 1.73e-02
PI3K AKT SIGNALING IN CANCER 88 3.94e-01 5.54e-01 0.08130 -6.26e-02 0.051800 3.10e-01 4.01e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 5.47e-01 6.82e-01 0.08130 6.87e-02 0.043300 3.38e-01 5.46e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 9.03e-01 9.38e-01 0.08120 6.34e-02 0.050800 7.16e-01 7.70e-01
PRE NOTCH EXPRESSION AND PROCESSING 63 5.29e-01 6.68e-01 0.08120 1.19e-02 -0.080300 8.70e-01 2.70e-01
VISUAL PHOTOTRANSDUCTION 58 5.55e-01 6.90e-01 0.08070 -7.69e-02 0.024500 3.11e-01 7.47e-01
MTOR SIGNALLING 40 6.67e-01 7.67e-01 0.08070 -2.01e-02 0.078100 8.26e-01 3.93e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 8.64e-01 9.15e-01 0.08060 4.53e-02 0.066700 7.54e-01 6.44e-01
NUCLEAR SIGNALING BY ERBB4 31 7.54e-01 8.39e-01 0.08050 4.95e-02 0.063500 6.33e-01 5.41e-01
DISEASES OF PROGRAMMED CELL DEATH 54 6.18e-01 7.32e-01 0.07980 5.62e-02 0.056600 4.75e-01 4.72e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 6.61e-01 7.62e-01 0.07920 4.56e-02 0.064800 5.89e-01 4.42e-01
GAB1 SIGNALOSOME 14 8.83e-01 9.26e-01 0.07870 2.71e-02 0.073800 8.60e-01 6.32e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 8.00e-01 8.70e-01 0.07840 3.26e-02 -0.071300 7.87e-01 5.54e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 4.01e-01 5.58e-01 0.07790 3.96e-02 0.067100 4.79e-01 2.31e-01
NOD1 2 SIGNALING PATHWAY 35 7.44e-01 8.32e-01 0.07780 5.60e-02 0.054000 5.67e-01 5.80e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 281 8.40e-02 2.00e-01 0.07760 7.35e-03 0.077300 8.32e-01 2.61e-02
INTERLEUKIN 20 FAMILY SIGNALING 14 8.82e-01 9.26e-01 0.07760 7.75e-02 0.004370 6.16e-01 9.77e-01
NUCLEAR ENVELOPE BREAKDOWN 47 6.74e-01 7.71e-01 0.07740 -4.67e-02 -0.061700 5.79e-01 4.64e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 5.24e-01 6.65e-01 0.07700 7.48e-02 0.018300 2.63e-01 7.84e-01
NEUREXINS AND NEUROLIGINS 54 6.01e-01 7.22e-01 0.07690 3.94e-02 -0.066100 6.17e-01 4.01e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 8.52e-01 9.08e-01 0.07670 -2.69e-03 0.076700 9.84e-01 5.73e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 8.52e-01 9.08e-01 0.07570 1.43e-02 0.074300 9.14e-01 5.75e-01
CELL CYCLE MITOTIC 470 2.23e-02 7.97e-02 0.07530 1.39e-02 0.074000 6.08e-01 6.15e-03
MITOTIC PROMETAPHASE 175 2.18e-01 3.93e-01 0.07510 7.25e-02 -0.019600 9.83e-02 6.54e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 8.78e-01 9.25e-01 0.07510 7.45e-02 -0.009980 6.18e-01 9.47e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 176 2.48e-01 4.22e-01 0.07480 6.87e-02 0.029700 1.16e-01 4.97e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 9.02e-01 9.37e-01 0.07480 -3.72e-02 -0.064900 8.17e-01 6.85e-01
DAG AND IP3 SIGNALING 40 7.20e-01 8.13e-01 0.07460 -7.41e-02 -0.008280 4.18e-01 9.28e-01
VLDLR INTERNALISATION AND DEGRADATION 12 9.00e-01 9.36e-01 0.07370 -5.41e-02 0.050100 7.46e-01 7.64e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 8.32e-01 8.98e-01 0.07310 -2.02e-02 0.070200 8.70e-01 5.68e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 6.61e-01 7.62e-01 0.07300 -3.64e-02 -0.063300 6.41e-01 4.17e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 9.11e-01 9.43e-01 0.07280 -5.86e-02 0.043200 7.36e-01 8.04e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 8.46e-01 9.04e-01 0.07200 -4.74e-02 0.054200 7.14e-01 6.75e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 141 3.13e-01 4.84e-01 0.07200 -4.03e-02 0.059600 4.09e-01 2.22e-01
OTHER INTERLEUKIN SIGNALING 20 8.65e-01 9.15e-01 0.07120 6.59e-02 0.027000 6.10e-01 8.34e-01
NEURONAL SYSTEM 363 6.84e-02 1.75e-01 0.07110 -7.10e-02 -0.003700 2.06e-02 9.04e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 7.85e-01 8.62e-01 0.07100 -1.60e-02 0.069200 8.78e-01 5.05e-01
CELLULAR SENESCENCE 140 3.42e-01 5.17e-01 0.07080 1.07e-02 -0.070000 8.26e-01 1.53e-01
VIRAL MESSENGER RNA SYNTHESIS 42 7.34e-01 8.25e-01 0.07080 -1.18e-02 -0.069800 8.95e-01 4.34e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 117 3.93e-01 5.52e-01 0.07080 5.70e-02 -0.041900 2.87e-01 4.34e-01
RHO GTPASE CYCLE 427 5.31e-02 1.50e-01 0.07060 6.07e-02 0.036000 3.19e-02 2.03e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 5.57e-01 6.92e-01 0.07060 -1.55e-02 0.068900 8.15e-01 3.00e-01
G1 S SPECIFIC TRANSCRIPTION 26 8.16e-01 8.84e-01 0.07050 -6.62e-02 0.024200 5.59e-01 8.31e-01
HOMOLOGY DIRECTED REPAIR 107 4.76e-01 6.31e-01 0.07050 -5.48e-02 -0.044300 3.28e-01 4.29e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 8.45e-01 9.04e-01 0.07020 1.78e-02 -0.067900 8.85e-01 5.81e-01
HCMV INFECTION 102 4.61e-01 6.17e-01 0.07000 6.76e-02 -0.018100 2.38e-01 7.52e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 8.55e-01 9.09e-01 0.06950 5.91e-02 0.036600 6.24e-01 7.61e-01
ION TRANSPORT BY P TYPE ATPASES 47 7.20e-01 8.13e-01 0.06930 -1.70e-02 -0.067200 8.40e-01 4.26e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 8.99e-01 9.36e-01 0.06930 -6.48e-02 0.024600 6.75e-01 8.73e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 9.05e-01 9.38e-01 0.06890 -4.76e-02 -0.049800 7.49e-01 7.38e-01
MAP2K AND MAPK ACTIVATION 36 7.85e-01 8.62e-01 0.06880 3.07e-02 0.061600 7.50e-01 5.22e-01
RAC3 GTPASE CYCLE 88 5.24e-01 6.65e-01 0.06870 -1.90e-02 0.066000 7.59e-01 2.85e-01
SIGNALING BY NOTCH 188 2.90e-01 4.70e-01 0.06870 3.82e-02 0.057100 3.67e-01 1.78e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 100 5.14e-01 6.62e-01 0.06840 2.77e-02 0.062600 6.33e-01 2.80e-01
CELLULAR RESPONSE TO HEAT STRESS 95 5.35e-01 6.70e-01 0.06830 3.08e-02 0.060900 6.04e-01 3.05e-01
REPRODUCTION 75 5.75e-01 7.05e-01 0.06790 4.06e-02 -0.054400 5.43e-01 4.16e-01
ION HOMEOSTASIS 48 7.18e-01 8.12e-01 0.06740 -6.71e-02 0.006080 4.21e-01 9.42e-01
RHOF GTPASE CYCLE 40 7.53e-01 8.38e-01 0.06680 -3.21e-02 0.058600 7.25e-01 5.22e-01
SIGNALING BY NOTCH1 75 5.87e-01 7.11e-01 0.06660 4.03e-02 -0.053100 5.46e-01 4.27e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 183 2.82e-01 4.59e-01 0.06620 -3.35e-02 0.057100 4.35e-01 1.84e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 9.13e-01 9.44e-01 0.06610 6.59e-02 0.005130 6.69e-01 9.73e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 7.01e-01 7.96e-01 0.06520 -6.51e-02 -0.004130 3.99e-01 9.57e-01
G ALPHA S SIGNALLING EVENTS 103 5.00e-01 6.52e-01 0.06500 -3.47e-02 0.054900 5.43e-01 3.36e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 7.66e-01 8.48e-01 0.06460 -2.92e-02 -0.057600 7.35e-01 5.04e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 9.27e-01 9.51e-01 0.06440 3.95e-02 0.050900 8.05e-01 7.51e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 8.39e-01 9.01e-01 0.06440 -6.43e-02 0.003900 5.56e-01 9.71e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.54e-01 6.11e-01 0.06430 -3.38e-02 -0.054700 4.96e-01 2.71e-01
ION CHANNEL TRANSPORT 138 4.48e-01 6.06e-01 0.06420 -2.94e-02 -0.057100 5.51e-01 2.48e-01
METABOLISM OF STEROID HORMONES 20 8.86e-01 9.28e-01 0.06410 8.46e-03 0.063500 9.48e-01 6.23e-01
PI METABOLISM 79 6.17e-01 7.32e-01 0.06370 -6.36e-02 0.002970 3.29e-01 9.64e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 8.69e-01 9.17e-01 0.06350 3.81e-03 -0.063400 9.75e-01 5.99e-01
MHC CLASS II ANTIGEN PRESENTATION 103 5.45e-01 6.82e-01 0.06350 1.14e-02 0.062400 8.42e-01 2.74e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 8.46e-01 9.04e-01 0.06340 5.02e-02 -0.038700 6.58e-01 7.33e-01
CIRCADIAN CLOCK 68 6.53e-01 7.57e-01 0.06310 -2.47e-02 0.058000 7.25e-01 4.08e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 8.48e-01 9.05e-01 0.06270 5.97e-02 0.019100 5.78e-01 8.59e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 9.47e-01 9.66e-01 0.06210 3.32e-02 0.052400 8.56e-01 7.74e-01
RET SIGNALING 37 8.07e-01 8.77e-01 0.06200 -1.62e-04 0.062000 9.99e-01 5.14e-01
NONHOMOLOGOUS END JOINING NHEJ 43 7.91e-01 8.66e-01 0.06200 -5.56e-02 -0.027400 5.28e-01 7.56e-01
ONCOGENE INDUCED SENESCENCE 32 8.41e-01 9.02e-01 0.06090 -1.51e-02 -0.059000 8.83e-01 5.63e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 8.62e-01 9.15e-01 0.06090 1.10e-02 -0.059900 9.23e-01 5.97e-01
REGULATION OF BETA CELL DEVELOPMENT 24 8.82e-01 9.26e-01 0.06090 -2.92e-02 -0.053400 8.05e-01 6.51e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 6.98e-01 7.93e-01 0.06050 -1.65e-02 0.058300 8.21e-01 4.24e-01
TRNA PROCESSING IN THE NUCLEUS 56 7.38e-01 8.27e-01 0.06050 -5.86e-03 -0.060200 9.40e-01 4.36e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 8.43e-01 9.03e-01 0.05890 -3.50e-02 -0.047400 7.20e-01 6.28e-01
CHROMOSOME MAINTENANCE 103 6.05e-01 7.26e-01 0.05890 2.98e-02 0.050800 6.01e-01 3.74e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 9.12e-01 9.43e-01 0.05890 -4.51e-02 -0.037800 7.34e-01 7.75e-01
SENSORY PERCEPTION 140 5.23e-01 6.65e-01 0.05750 3.11e-02 0.048400 5.26e-01 3.24e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 6.40e-01 7.49e-01 0.05750 -3.31e-04 0.057500 9.96e-01 3.46e-01
HIV TRANSCRIPTION ELONGATION 42 8.15e-01 8.84e-01 0.05720 5.71e-02 0.003540 5.22e-01 9.68e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 82 7.02e-01 7.97e-01 0.05550 -4.52e-02 -0.032200 4.80e-01 6.15e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 8.62e-01 9.15e-01 0.05530 -5.07e-02 -0.022200 6.09e-01 8.23e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 8.97e-01 9.36e-01 0.05490 5.16e-02 -0.018500 6.68e-01 8.78e-01
PRC2 METHYLATES HISTONES AND DNA 29 8.83e-01 9.26e-01 0.05280 5.22e-02 -0.008290 6.27e-01 9.38e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 8.79e-01 9.25e-01 0.05250 2.38e-02 0.046800 8.13e-01 6.42e-01
DEATH RECEPTOR SIGNALLING 134 5.70e-01 7.02e-01 0.05220 5.12e-02 -0.010500 3.07e-01 8.35e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 9.18e-01 9.45e-01 0.05090 -4.80e-02 0.016800 7.03e-01 8.94e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 9.30e-01 9.53e-01 0.05080 4.97e-02 -0.010700 7.15e-01 9.37e-01
VXPX CARGO TARGETING TO CILIUM 19 9.29e-01 9.53e-01 0.05060 5.06e-02 -0.001210 7.03e-01 9.93e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 8.27e-01 8.95e-01 0.04960 3.08e-02 -0.038900 7.12e-01 6.41e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 8.91e-01 9.32e-01 0.04910 -3.36e-02 -0.035900 7.35e-01 7.17e-01
L1CAM INTERACTIONS 109 6.79e-01 7.76e-01 0.04910 4.88e-02 0.005980 3.79e-01 9.14e-01
CELL CYCLE 588 1.33e-01 2.78e-01 0.04900 6.19e-03 0.048600 7.98e-01 4.51e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 9.24e-01 9.50e-01 0.04860 2.37e-02 -0.042400 8.51e-01 7.37e-01
SIGNALING BY NOTCH3 48 8.39e-01 9.01e-01 0.04850 1.32e-02 -0.046600 8.74e-01 5.76e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 51 8.25e-01 8.93e-01 0.04850 -3.70e-02 0.031300 6.47e-01 6.99e-01
SUMOYLATION 162 5.81e-01 7.07e-01 0.04830 -4.63e-02 -0.013800 3.09e-01 7.63e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 9.36e-01 9.58e-01 0.04810 4.80e-02 -0.003050 7.17e-01 9.82e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 9.00e-01 9.36e-01 0.04800 -4.79e-02 0.004100 6.50e-01 9.69e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 184 5.17e-01 6.63e-01 0.04800 -1.68e-02 0.044900 6.95e-01 2.94e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 7.68e-01 8.50e-01 0.04750 1.92e-02 -0.043500 7.75e-01 5.18e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 27 9.18e-01 9.45e-01 0.04560 5.95e-03 -0.045200 9.57e-01 6.85e-01
REGULATION OF TP53 ACTIVITY 148 6.19e-01 7.32e-01 0.04510 3.10e-02 -0.032700 5.15e-01 4.92e-01
DISEASES OF GLYCOSYLATION 124 6.71e-01 7.69e-01 0.04500 2.44e-02 -0.037800 6.39e-01 4.68e-01
DNA METHYLATION 20 9.38e-01 9.58e-01 0.04470 3.66e-02 -0.025700 7.77e-01 8.42e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 7.75e-01 8.55e-01 0.04420 -5.40e-04 -0.044200 9.93e-01 4.76e-01
EXTENSION OF TELOMERES 50 8.59e-01 9.13e-01 0.04370 3.82e-02 -0.021200 6.41e-01 7.95e-01
HCMV LATE EVENTS 64 8.28e-01 8.95e-01 0.04350 -4.14e-02 0.013300 5.67e-01 8.54e-01
RNA POLYMERASE II TRANSCRIPTION 1083 5.34e-02 1.50e-01 0.04340 -4.31e-02 0.005450 1.75e-02 7.64e-01
PD 1 SIGNALING 10 9.72e-01 9.83e-01 0.04280 4.22e-02 -0.007330 8.17e-01 9.68e-01
ACYL CHAIN REMODELLING OF PC 17 9.59e-01 9.75e-01 0.04200 2.90e-02 0.030500 8.36e-01 8.28e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 8.99e-01 9.36e-01 0.04100 6.26e-04 -0.041000 9.94e-01 6.46e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 9.67e-01 9.81e-01 0.04000 -3.34e-02 0.022000 8.35e-01 8.91e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 9.17e-01 9.45e-01 0.04000 -7.60e-03 0.039300 9.38e-01 6.88e-01
PHOSPHOLIPID METABOLISM 185 6.41e-01 7.49e-01 0.04000 -2.77e-03 0.039900 9.48e-01 3.50e-01
MRNA CAPPING 29 9.37e-01 9.58e-01 0.03970 1.51e-02 0.036700 8.88e-01 7.32e-01
MEIOSIS 63 8.77e-01 9.25e-01 0.03800 -1.33e-02 -0.035600 8.55e-01 6.25e-01
GLYCOLYSIS 66 8.68e-01 9.17e-01 0.03780 -6.25e-05 0.037800 9.99e-01 5.95e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 8.92e-01 9.32e-01 0.03640 -1.70e-02 -0.032200 8.19e-01 6.64e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 9.48e-01 9.66e-01 0.03580 -3.07e-02 0.018400 7.86e-01 8.71e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 9.16e-01 9.45e-01 0.03460 -2.86e-02 -0.019400 7.21e-01 8.08e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 9.18e-01 9.45e-01 0.03390 1.22e-02 0.031600 8.79e-01 6.94e-01
HYALURONAN METABOLISM 15 9.76e-01 9.86e-01 0.03190 -3.03e-02 0.009980 8.39e-01 9.47e-01
GOLGI TO ER RETROGRADE TRANSPORT 118 8.38e-01 9.01e-01 0.03110 -7.72e-03 0.030100 8.85e-01 5.72e-01
INTERLEUKIN 6 SIGNALING 10 9.89e-01 9.93e-01 0.02860 -1.79e-02 -0.022400 9.22e-01 9.02e-01
METABOLISM OF FAT SOLUBLE VITAMINS 31 9.63e-01 9.79e-01 0.02860 2.92e-03 0.028500 9.78e-01 7.84e-01
ONCOGENIC MAPK SIGNALING 77 9.25e-01 9.50e-01 0.02580 -3.43e-03 0.025600 9.59e-01 6.98e-01
RHOD GTPASE CYCLE 50 9.55e-01 9.72e-01 0.02580 1.51e-02 0.020900 8.54e-01 7.98e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 9.66e-01 9.80e-01 0.02350 3.97e-03 0.023100 9.64e-01 7.93e-01
TELOMERE MAINTENANCE 79 9.41e-01 9.61e-01 0.02330 9.99e-03 0.021100 8.78e-01 7.46e-01
P38MAPK EVENTS 13 9.89e-01 9.93e-01 0.02320 1.53e-02 -0.017400 9.24e-01 9.13e-01
G0 AND EARLY G1 24 9.80e-01 9.89e-01 0.02280 -1.52e-02 0.017000 8.98e-01 8.85e-01
MISMATCH REPAIR 14 9.90e-01 9.93e-01 0.02160 2.16e-02 0.000337 8.89e-01 9.98e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 9.93e-01 9.94e-01 0.01990 -1.40e-02 -0.014200 9.30e-01 9.30e-01
MUSCLE CONTRACTION 162 9.04e-01 9.38e-01 0.01970 1.51e-02 -0.012700 7.40e-01 7.81e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 9.69e-01 9.82e-01 0.01930 -1.54e-02 -0.011600 8.36e-01 8.76e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 85 9.64e-01 9.79e-01 0.01760 -1.06e-02 -0.014100 8.66e-01 8.22e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 35 9.87e-01 9.93e-01 0.01640 1.06e-02 0.012500 9.13e-01 8.98e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 9.71e-01 9.83e-01 0.01630 1.49e-02 0.006650 8.22e-01 9.20e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 9.91e-01 9.93e-01 0.01510 1.68e-03 -0.015100 9.88e-01 8.94e-01
SNRNP ASSEMBLY 51 9.83e-01 9.91e-01 0.01500 -4.36e-03 -0.014400 9.57e-01 8.59e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 9.91e-01 9.93e-01 0.01160 2.71e-03 -0.011300 9.76e-01 8.99e-01
ESTROGEN DEPENDENT GENE EXPRESSION 100 9.88e-01 9.93e-01 0.00920 -9.18e-03 -0.000556 8.74e-01 9.92e-01
TRANSCRIPTIONAL REGULATION BY TP53 338 9.76e-01 9.86e-01 0.00682 -4.05e-03 0.005490 8.98e-01 8.63e-01
FLT3 SIGNALING IN DISEASE 27 1.00e+00 1.00e+00 0.00120 -3.30e-04 0.001150 9.98e-01 9.92e-01


Detailed Gene set reports


EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
metric value
setSize 87
pMANOVA 3.59e-25
p.adjustMANOVA 1.05e-22
s.dist 0.68
s.LPS 0.443
s.OVA 0.515
p.LPS 9.24e-13
p.OVA 9.3e-17




Top 20 genes
Gene LPS OVA
Rps8 7269 7309
Rpl23a 6015 7526
Rps9 5470 7584
Eef1a2 6134 6745
Rps29 6454 5764
Rps4x 5413 6683
Rps27a 5721 6253
Rpl23 5508 6486
Rpl6 5265 6716
Rps27l 4686 7434
Eef1g 4576 7432
Rpl37a 5424 6156
Rps25 4264 7814
Rpl24 4398 7497
Eef2 6018 5219
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300

Click HERE to show all gene set members

All member genes
LPS OVA
Eef1a1 -2823 7023
Eef1a2 6134 6745
Eef1b2 2756 5400
Eef1d 6661 3423
Eef1g 4576 7432
Eef2 6018 5219
Fau 3642 5713
Rpl10 3681 -3707
Rpl10a 887 725
Rpl11 2278 5271
Rpl12 3715 -7459
Rpl13 3904 3220
Rpl13a 405 6090
Rpl14 3947 5501
Rpl15 -3300 3005
Rpl17 -2674 5569
Rpl18 1839 261
Rpl18a 3851 5321
Rpl19 2619 3550
Rpl21 2971 2664
Rpl22 727 5843
Rpl22l1 -3342 6907
Rpl23 5508 6486
Rpl23a 6015 7526
Rpl24 4398 7497
Rpl26 7183 3616
Rpl27 526 5180
Rpl27a 2840 2777
Rpl28 6951 830
Rpl29 -308 3645
Rpl3 2605 5902
Rpl30 3372 5167
Rpl31 3208 5659
Rpl32 3941 4603
Rpl34 -368 3497
Rpl35 6121 4242
Rpl35a 4654 5451
Rpl36 2400 -378
Rpl36a 919 4018
Rpl36al 2700 1803
Rpl37 5410 2939
Rpl37a 5424 6156
Rpl38 6478 3980
Rpl39 -2409 4847
Rpl4 866 6114
Rpl5 1278 6005
Rpl6 5265 6716
Rpl7 -1345 4991
Rpl7a 4402 2277
Rpl8 5073 2661
Rpl9 1473 5111
Rplp0 -305 5857
Rplp1 4410 -555
Rplp2 6464 772
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098
Uba52 3801 4656



TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
metric value
setSize 11
pMANOVA 0.000853
p.adjustMANOVA 0.00642
s.dist 0.658
s.LPS 0.0789
s.OVA 0.654
p.LPS 0.65
p.OVA 0.000174




Top 20 genes
Gene LPS OVA
Unc93b1 5057 5731
Ctsl 4754 5446
Ctsk 3969 4371
Tlr7 2249 7062
Hsp90b1 2500 6284
Lgmn 922 7880

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All member genes
LPS OVA
Cnpy3 -1459 1644
Ctsb -1703 7800
Ctsk 3969 4371
Ctsl 4754 5446
Ctss -1895 7906
Hsp90b1 2500 6284
Lgmn 922 7880
Tlr3 -7409 4630
Tlr7 2249 7062
Tlr9 -5004 -1431
Unc93b1 5057 5731



MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
metric value
setSize 11
pMANOVA 0.00129
p.adjustMANOVA 0.00888
s.dist 0.618
s.LPS -0.567
s.OVA 0.245
p.LPS 0.00112
p.OVA 0.16




Top 20 genes
Gene LPS OVA
Rap1b -8318 6947
Rac1 -7036 7670
Gab1 -4803 7454
Rap1a -5206 6754
Crk -5149 6483
Crkl -5466 4716
Grb2 -3203 1149

Click HERE to show all gene set members

All member genes
LPS OVA
Crk -5149 6483
Crkl -5466 4716
Dock7 -6766 -8138
Gab1 -4803 7454
Grb2 -3203 1149
Hgf -7725 -5021
Met -7731 -4405
Rac1 -7036 7670
Rap1a -5206 6754
Rap1b -8318 6947
Rapgef1 4587 -3482



COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 1.26e-13
p.adjustMANOVA 7.33e-12
s.dist 0.612
s.LPS 0.295
s.OVA 0.536
p.LPS 0.000133
p.OVA 3.88e-12




Top 20 genes
Gene LPS OVA
Timmdc1 7357 7319
Ndufa12 6998 7523
Ndufa10 5715 7438
Ndufaf1 5653 7100
Ndufa13 6592 5812
Ndufs2 4508 7474
Ndufaf2 4874 6154
Ndufaf6 4271 6561
Ndufs5 5914 4689
Ndufa6 5352 4748
Tmem126b 7101 3219
Ndufs6 5835 3821
Ndufb8 3172 6153
Ndufv1 5328 3456
Ndufs4 2427 7475
Ndufb5 2197 7899
Ndufb3 6621 2486
Ndufb9 2239 6715
Ndufa5 1897 7071
Ndufaf5 2350 5651

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 608 1981
Ecsit 1595 2336
mt-Nd1 -3437 7547
mt-Nd2 -4161 7398
mt-Nd3 -125 7652
mt-Nd4 -4483 7747
mt-Nd5 -4792 7472
mt-Nd6 -5972 7648
Ndufa1 4455 2808
Ndufa10 5715 7438
Ndufa11 2653 -920
Ndufa12 6998 7523
Ndufa13 6592 5812
Ndufa2 3298 -1358
Ndufa3 5066 -187
Ndufa5 1897 7071
Ndufa6 5352 4748
Ndufa7 1187 4511
Ndufa8 3953 1692
Ndufa9 214 -1151
Ndufab1 1653 5587
Ndufaf1 5653 7100
Ndufaf2 4874 6154
Ndufaf3 -710 -1141
Ndufaf4 -86 7830
Ndufaf5 2350 5651
Ndufaf6 4271 6561
Ndufaf7 952 -1197
Ndufb1 -3377 3408
Ndufb10 7581 314
Ndufb11 56 6442
Ndufb2 5312 1230
Ndufb3 6621 2486
Ndufb4 -1779 6522
Ndufb5 2197 7899
Ndufb6 2316 4162
Ndufb7 4405 1364
Ndufb8 3172 6153
Ndufb9 2239 6715
Ndufc1 575 7834
Ndufc2 -860 4791
Ndufs1 -1826 6346
Ndufs2 4508 7474
Ndufs3 -2761 5967
Ndufs4 2427 7475
Ndufs5 5914 4689
Ndufs6 5835 3821
Ndufs7 4329 2096
Ndufs8 2347 349
Ndufv1 5328 3456
Ndufv2 -2931 7852
Ndufv3 1927 201
Nubpl -4045 24
Timmdc1 7357 7319
Tmem126b 7101 3219
Tmem186 333 -7228



RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
metric value
setSize 94
pMANOVA 1.66e-21
p.adjustMANOVA 2.15e-19
s.dist 0.603
s.LPS 0.38
s.OVA 0.468
p.LPS 1.94e-10
p.OVA 4.37e-15




Top 20 genes
Gene LPS OVA
Rps8 7269 7309
Rpl23a 6015 7526
Rps9 5470 7584
Rps29 6454 5764
Rps4x 5413 6683
Rps27a 5721 6253
Rpl23 5508 6486
Rpl6 5265 6716
Rps27l 4686 7434
Rpl37a 5424 6156
Rps25 4264 7814
Rpl24 4398 7497
Ddit3 7454 4239
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300
Rpl26 7183 3616
Rpl35 6121 4242

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -6224 7462
Atf2 -8293 1693
Atf3 2584 -1128
Atf4 3752 -2098
Cebpb -4190 4494
Cebpg -1728 646
Ddit3 7454 4239
Eif2ak4 833 -8346
Eif2s1 -1078 7334
Eif2s2 -1382 7342
Eif2s3x -1911 7278
Fau 3642 5713
Gcn1 6033 -7702
Impact 871 5521
Rpl10 3681 -3707
Rpl10a 887 725
Rpl11 2278 5271
Rpl12 3715 -7459
Rpl13 3904 3220
Rpl13a 405 6090
Rpl14 3947 5501
Rpl15 -3300 3005
Rpl17 -2674 5569
Rpl18 1839 261
Rpl18a 3851 5321
Rpl19 2619 3550
Rpl21 2971 2664
Rpl22 727 5843
Rpl22l1 -3342 6907
Rpl23 5508 6486
Rpl23a 6015 7526
Rpl24 4398 7497
Rpl26 7183 3616
Rpl27 526 5180
Rpl27a 2840 2777
Rpl28 6951 830
Rpl29 -308 3645
Rpl3 2605 5902
Rpl30 3372 5167
Rpl31 3208 5659
Rpl32 3941 4603
Rpl34 -368 3497
Rpl35 6121 4242
Rpl35a 4654 5451
Rpl36 2400 -378
Rpl36a 919 4018
Rpl36al 2700 1803
Rpl37 5410 2939
Rpl37a 5424 6156
Rpl38 6478 3980
Rpl39 -2409 4847
Rpl4 866 6114
Rpl5 1278 6005
Rpl6 5265 6716
Rpl7 -1345 4991
Rpl7a 4402 2277
Rpl8 5073 2661
Rpl9 1473 5111
Rplp0 -305 5857
Rplp1 4410 -555
Rplp2 6464 772
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098
Uba52 3801 4656



ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
metric value
setSize 12
pMANOVA 0.00227
p.adjustMANOVA 0.0143
s.dist 0.601
s.LPS 0.372
s.OVA 0.472
p.LPS 0.0257
p.OVA 0.00465




Top 20 genes
Gene LPS OVA
Elovl1 7795 8073
Hsd17b4 4859 7354
Fads2 4719 4713
Fads1 5080 4254
Scp2 1586 7594
Elovl5 403 7730

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All member genes
LPS OVA
Abcd1 5577 -2467
Acaa1a 5943 -6780
Acot8 5671 -1053
Acox1 -5295 5263
Acsl1 -4198 4259
Elovl1 7795 8073
Elovl2 -895 5553
Elovl5 403 7730
Fads1 5080 4254
Fads2 4719 4713
Hsd17b4 4859 7354
Scp2 1586 7594



SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
metric value
setSize 106
pMANOVA 3.87e-23
p.adjustMANOVA 6.45e-21
s.dist 0.588
s.LPS 0.324
s.OVA 0.491
p.LPS 8.1e-09
p.OVA 2.38e-18




Top 20 genes
Gene LPS OVA
Rps8 7269 7309
Rpl23a 6015 7526
Rps9 5470 7584
Rps29 6454 5764
Srp72 5011 7221
Rps4x 5413 6683
Rps27a 5721 6253
Rpl23 5508 6486
Rpl6 5265 6716
Rps27l 4686 7434
Rpl37a 5424 6156
Rps25 4264 7814
Rpl24 4398 7497
Srpr 4716 6546
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300
Sec11c 4096 6779

Click HERE to show all gene set members

All member genes
LPS OVA
Ddost -1461 6071
Fau 3642 5713
Rpl10 3681 -3707
Rpl10a 887 725
Rpl11 2278 5271
Rpl12 3715 -7459
Rpl13 3904 3220
Rpl13a 405 6090
Rpl14 3947 5501
Rpl15 -3300 3005
Rpl17 -2674 5569
Rpl18 1839 261
Rpl18a 3851 5321
Rpl19 2619 3550
Rpl21 2971 2664
Rpl22 727 5843
Rpl22l1 -3342 6907
Rpl23 5508 6486
Rpl23a 6015 7526
Rpl24 4398 7497
Rpl26 7183 3616
Rpl27 526 5180
Rpl27a 2840 2777
Rpl28 6951 830
Rpl29 -308 3645
Rpl3 2605 5902
Rpl30 3372 5167
Rpl31 3208 5659
Rpl32 3941 4603
Rpl34 -368 3497
Rpl35 6121 4242
Rpl35a 4654 5451
Rpl36 2400 -378
Rpl36a 919 4018
Rpl36al 2700 1803
Rpl37 5410 2939
Rpl37a 5424 6156
Rpl38 6478 3980
Rpl39 -2409 4847
Rpl4 866 6114
Rpl5 1278 6005
Rpl6 5265 6716
Rpl7 -1345 4991
Rpl7a 4402 2277
Rpl8 5073 2661
Rpl9 1473 5111
Rplp0 -305 5857
Rplp1 4410 -555
Rplp2 6464 772
Rpn1 -4160 2583
Rpn2 1732 3254
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098
Sec11a 3183 816
Sec11c 4096 6779
Sec61a1 -2394 -5455
Sec61a2 1707 -6142
Sec61b 1066 2089
Sec61g -4233 3214
Spcs1 759 7922
Spcs2 -1136 5440
Spcs3 -7044 6006
Srp14 938 3818
Srp19 3296 4093
Srp54a -5651 7016
Srp68 968 -975
Srp72 5011 7221
Srp9 -3091 5615
Srpr 4716 6546
Srprb 3731 5427
Ssr1 -5626 5006
Ssr2 -2630 4033
Ssr3 -5720 7546
Ssr4 -186 -81
Tram1 -8098 2524
Uba52 3801 4656



ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
metric value
setSize 19
pMANOVA 3.08e-05
p.adjustMANOVA 0.000427
s.dist 0.588
s.LPS -0.222
s.OVA 0.545
p.LPS 0.0934
p.OVA 3.94e-05




Top 20 genes
Gene LPS OVA
P2ry12 -6746 7371
Gng12 -6342 7762
Gnai1 -8727 5036
Gng10 -5606 7084
Gnai3 -5034 6993
Gnb4 -8083 2628
Gng2 -8001 1552
Gng5 -818 7006
Gnai2 -1157 4083
Gnb1 -6678 592
Gng13 -3686 918
Gng11 -360 6592
Gng7 -405 5101
Gnb2 -173 1359

Click HERE to show all gene set members

All member genes
LPS OVA
Gnai1 -8727 5036
Gnai2 -1157 4083
Gnai3 -5034 6993
Gnb1 -6678 592
Gnb2 -173 1359
Gnb4 -8083 2628
Gnb5 2322 6656
Gng10 -5606 7084
Gng11 -360 6592
Gng12 -6342 7762
Gng13 -3686 918
Gng2 -8001 1552
Gng3 4649 4211
Gng4 688 2010
Gng5 -818 7006
Gng7 -405 5101
Gng8 5762 2068
Gngt2 4501 2828
P2ry12 -6746 7371



INITIAL TRIGGERING OF COMPLEMENT

INITIAL TRIGGERING OF COMPLEMENT
metric value
setSize 10
pMANOVA 0.00852
p.adjustMANOVA 0.0396
s.dist 0.582
s.LPS 0.474
s.OVA 0.337
p.LPS 0.00942
p.OVA 0.0649




Top 20 genes
Gene LPS OVA
C1qb 6799 7122
C2 7641 5519
C1qc 4296 7483
C1qa 2948 7430
Masp1 2774 7044
C4b 4806 3711

Click HERE to show all gene set members

All member genes
LPS OVA
C1qa 2948 7430
C1qb 6799 7122
C1qc 4296 7483
C2 7641 5519
C4b 4806 3711
Cfb -7654 -6022
Cfp 7564 -1864
Gzmm -541 -2227
Masp1 2774 7044
Masp2 5858 -2258



CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
metric value
setSize 10
pMANOVA 0.00458
p.adjustMANOVA 0.0245
s.dist 0.578
s.LPS -0.409
s.OVA 0.408
p.LPS 0.0251
p.OVA 0.0253




Top 20 genes
Gene LPS OVA
Rac1 -7036 7670
Cdc42 -6734 6326
Pak1 -7207 4464
Cd86 -6899 4265
Pak2 -2249 7894
Pak3 -3652 4264
Grb2 -3203 1149
Fyn -3965 235

Click HERE to show all gene set members

All member genes
LPS OVA
Cd86 -6899 4265
Cdc42 -6734 6326
Fyn -3965 235
Grb2 -3203 1149
Lck -5195 -4236
Pak1 -7207 4464
Pak2 -2249 7894
Pak3 -3652 4264
Rac1 -7036 7670
Vav1 7575 -197



EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION
metric value
setSize 114
pMANOVA 6.39e-23
p.adjustMANOVA 9.31e-21
s.dist 0.565
s.LPS 0.306
s.OVA 0.475
p.LPS 1.75e-08
p.OVA 1.98e-18




Top 20 genes
Gene LPS OVA
Rps8 7269 7309
Rpl23a 6015 7526
Rps9 5470 7584
Eif5b 7138 5415
Rps29 6454 5764
Rps4x 5413 6683
Rps27a 5721 6253
Rpl23 5508 6486
Rpl6 5265 6716
Rps27l 4686 7434
Rpl37a 5424 6156
Rps25 4264 7814
Rpl24 4398 7497
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300
Rpl26 7183 3616
Rpl35 6121 4242

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7593 3725
Eif2b1 -7905 -2147
Eif2b2 4322 4484
Eif2b3 -6509 -1339
Eif2b4 6272 2991
Eif2b5 2116 3309
Eif2s1 -1078 7334
Eif2s2 -1382 7342
Eif2s3x -1911 7278
Eif3a 7515 -4662
Eif3b 3392 1727
Eif3c 2560 2726
Eif3d 384 142
Eif3e -7886 6871
Eif3f 2086 5717
Eif3g 3250 4179
Eif3h 2547 5339
Eif3i 2097 2268
Eif3j1 2129 346
Eif3j2 -2616 7283
Eif3k -2270 -1119
Eif3l -593 3716
Eif3m -7076 6797
Eif4a1 -1988 2217
Eif4a2 -7548 5782
Eif4b -1893 4200
Eif4e -4688 6657
Eif4ebp1 1853 3169
Eif4g1 5626 -6388
Eif4h -2503 -1074
Eif5 -7015 4890
Eif5b 7138 5415
Fau 3642 5713
Pabpc1 -1115 6437
Rpl10 3681 -3707
Rpl10a 887 725
Rpl11 2278 5271
Rpl12 3715 -7459
Rpl13 3904 3220
Rpl13a 405 6090
Rpl14 3947 5501
Rpl15 -3300 3005
Rpl17 -2674 5569
Rpl18 1839 261
Rpl18a 3851 5321
Rpl19 2619 3550
Rpl21 2971 2664
Rpl22 727 5843
Rpl22l1 -3342 6907
Rpl23 5508 6486
Rpl23a 6015 7526
Rpl24 4398 7497
Rpl26 7183 3616
Rpl27 526 5180
Rpl27a 2840 2777
Rpl28 6951 830
Rpl29 -308 3645
Rpl3 2605 5902
Rpl30 3372 5167
Rpl31 3208 5659
Rpl32 3941 4603
Rpl34 -368 3497
Rpl35 6121 4242
Rpl35a 4654 5451
Rpl36 2400 -378
Rpl36a 919 4018
Rpl36al 2700 1803
Rpl37 5410 2939
Rpl37a 5424 6156
Rpl38 6478 3980
Rpl39 -2409 4847
Rpl4 866 6114
Rpl5 1278 6005
Rpl6 5265 6716
Rpl7 -1345 4991
Rpl7a 4402 2277
Rpl8 5073 2661
Rpl9 1473 5111
Rplp0 -305 5857
Rplp1 4410 -555
Rplp2 6464 772
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098
Uba52 3801 4656



NUCLEOTIDE LIKE PURINERGIC RECEPTORS

NUCLEOTIDE LIKE PURINERGIC RECEPTORS
metric value
setSize 13
pMANOVA 0.00244
p.adjustMANOVA 0.0149
s.dist 0.557
s.LPS 0.0356
s.OVA 0.556
p.LPS 0.824
p.OVA 0.000524




Top 20 genes
Gene LPS OVA
Adora3 6377 7065
Gpr17 7438 5816
P2ry1 4895 7335
Adora2b 4071 5004
P2ry13 1703 5875
Lpar6 2149 567

Click HERE to show all gene set members

All member genes
LPS OVA
Adora1 -3794 928
Adora2a -426 4685
Adora2b 4071 5004
Adora3 6377 7065
Gpr17 7438 5816
Lpar4 -7642 2281
Lpar6 2149 567
P2ry1 4895 7335
P2ry12 -6746 7371
P2ry13 1703 5875
P2ry14 -794 7051
P2ry2 -6591 -494
P2ry6 -2960 3701



RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 102
pMANOVA 4.13e-20
p.adjustMANOVA 4.38e-18
s.dist 0.553
s.LPS 0.21
s.OVA 0.512
p.LPS 0.000246
p.OVA 3.92e-19




Top 20 genes
Gene LPS OVA
Timmdc1 7357 7319
Ndufa12 6998 7523
Ndufa10 5715 7438
Ndufaf1 5653 7100
Ndufa13 6592 5812
Ndufs2 4508 7474
Ndufaf2 4874 6154
Ndufaf6 4271 6561
Ndufs5 5914 4689
Sco2 4448 5969
Ndufa6 5352 4748
Taco1 5103 4947
Cox5b 4770 5257
Surf1 3345 6962
Tmem126b 7101 3219
Ndufs6 5835 3821
Cox5a 2967 7056
Coq10a 3815 5334
Ndufb8 3172 6153
Ndufv1 5328 3456

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 608 1981
Coq10a 3815 5334
Coq10b -3900 7972
Cox11 4944 -7059
Cox14 -791 -2266
Cox16 -5837 4702
Cox18 1918 4164
Cox19 6179 -4411
Cox20 494 5292
Cox4i1 2759 419
Cox5a 2967 7056
Cox5b 4770 5257
Cox6a1 533 6489
Cox6b1 3314 1740
Cox6c 1236 4892
Cox7a2l 1780 7722
Cox7b 367 4500
Cox7c 1266 5795
Cox8a 139 4534
Cyc1 1431 2316
Cycs -4448 7302
Ecsit 1595 2336
Etfa -2755 3110
Etfb -1009 1992
Etfdh -5075 1102
Lrpprc -4802 -6897
mt-Co1 -2709 7832
mt-Co2 -2570 7453
mt-Co3 -1213 7241
mt-Cytb -1700 7368
mt-Nd1 -3437 7547
mt-Nd2 -4161 7398
mt-Nd3 -125 7652
mt-Nd4 -4483 7747
mt-Nd5 -4792 7472
mt-Nd6 -5972 7648
Ndufa1 4455 2808
Ndufa10 5715 7438
Ndufa11 2653 -920
Ndufa12 6998 7523
Ndufa13 6592 5812
Ndufa2 3298 -1358
Ndufa3 5066 -187
Ndufa4 647 6888
Ndufa5 1897 7071
Ndufa6 5352 4748
Ndufa7 1187 4511
Ndufa8 3953 1692
Ndufa9 214 -1151
Ndufab1 1653 5587
Ndufaf1 5653 7100
Ndufaf2 4874 6154
Ndufaf3 -710 -1141
Ndufaf4 -86 7830
Ndufaf5 2350 5651
Ndufaf6 4271 6561
Ndufaf7 952 -1197
Ndufb1 -3377 3408
Ndufb10 7581 314
Ndufb11 56 6442
Ndufb2 5312 1230
Ndufb3 6621 2486
Ndufb4 -1779 6522
Ndufb5 2197 7899
Ndufb6 2316 4162
Ndufb7 4405 1364
Ndufb8 3172 6153
Ndufb9 2239 6715
Ndufc1 575 7834
Ndufc2 -860 4791
Ndufs1 -1826 6346
Ndufs2 4508 7474
Ndufs3 -2761 5967
Ndufs4 2427 7475
Ndufs5 5914 4689
Ndufs6 5835 3821
Ndufs7 4329 2096
Ndufs8 2347 349
Ndufv1 5328 3456
Ndufv2 -2931 7852
Ndufv3 1927 201
Nubpl -4045 24
Sco1 -8421 89
Sco2 4448 5969
Sdha -195 5190
Sdhb -706 4437
Sdhc 266 7696
Sdhd -1586 4980
Surf1 3345 6962
Taco1 5103 4947
Timmdc1 7357 7319
Tmem126b 7101 3219
Tmem186 333 -7228
Trap1 6956 -274
Uqcr10 2812 941
Uqcr11 2518 -883
Uqcrb 2530 7255
Uqcrc1 3152 822
Uqcrc2 -6454 5459
Uqcrfs1 -1373 3878
Uqcrh 1339 3287
Uqcrq 2765 4378



PINK1 PRKN MEDIATED MITOPHAGY

PINK1 PRKN MEDIATED MITOPHAGY
metric value
setSize 22
pMANOVA 6.14e-05
p.adjustMANOVA 0.000738
s.dist 0.553
s.LPS 0.188
s.OVA 0.521
p.LPS 0.127
p.OVA 2.36e-05




Top 20 genes
Gene LPS OVA
Rps27a 5721 6253
Prkn 7375 4057
Map1lc3a 5523 4269
Tomm6 3226 6850
Uba52 3801 4656
Map1lc3b 2143 5936
Ubb 2566 4439
Vdac1 1584 5837
Tomm7 2623 2388
Mterf3 1370 4077
Sqstm1 722 5401
Tomm40 3703 1046
Tomm5 1860 1984

Click HERE to show all gene set members

All member genes
LPS OVA
Atg12 -4513 4907
Atg5 -3858 6426
Map1lc3a 5523 4269
Map1lc3b 2143 5936
Mfn1 5450 -1471
Mfn2 4722 -564
Mterf3 1370 4077
Pink1 -1899 5577
Prkn 7375 4057
Rps27a 5721 6253
Sqstm1 722 5401
Tomm20 -7837 7654
Tomm22 -5399 5772
Tomm40 3703 1046
Tomm5 1860 1984
Tomm6 3226 6850
Tomm7 2623 2388
Tomm70a -8174 5555
Uba52 3801 4656
Ubb 2566 4439
Ubc 3034 -673
Vdac1 1584 5837



SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
metric value
setSize 12
pMANOVA 0.00573
p.adjustMANOVA 0.0283
s.dist 0.553
s.LPS 0.32
s.OVA 0.451
p.LPS 0.0553
p.OVA 0.00681




Top 20 genes
Gene LPS OVA
Ptgis 7582 6045
Rxra 5738 6255
Hsd17b4 4859 7354
Hsd3b7 4571 7469
Cyp27a1 5717 4414
Slc27a2 6192 2593
Scp2 1586 7594

Click HERE to show all gene set members

All member genes
LPS OVA
Acot8 5671 -1053
Amacr -5665 2232
Cyp27a1 5717 4414
Cyp7b1 -691 4704
Hsd17b4 4859 7354
Hsd3b7 4571 7469
Ncoa1 -5288 -2924
Ncoa2 -4236 -2251
Ptgis 7582 6045
Rxra 5738 6255
Scp2 1586 7594
Slc27a2 6192 2593



ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
metric value
setSize 59
pMANOVA 9.83e-12
p.adjustMANOVA 4.77e-10
s.dist 0.551
s.LPS 0.27
s.OVA 0.48
p.LPS 0.000332
p.OVA 1.75e-10




Top 20 genes
Gene LPS OVA
Rps8 7269 7309
Rps9 5470 7584
Rps29 6454 5764
Rps4x 5413 6683
Rps27a 5721 6253
Rps27l 4686 7434
Rps25 4264 7814
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300
Fau 3642 5713
Rps24 3022 6357
Rps21 5587 3173
Rps7 2681 6267
Eif3h 2547 5339
Eif3g 3250 4179
Rps11 3856 3501
Rps13 5831 2141

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7593 3725
Eif2s1 -1078 7334
Eif2s2 -1382 7342
Eif2s3x -1911 7278
Eif3a 7515 -4662
Eif3b 3392 1727
Eif3c 2560 2726
Eif3d 384 142
Eif3e -7886 6871
Eif3f 2086 5717
Eif3g 3250 4179
Eif3h 2547 5339
Eif3i 2097 2268
Eif3j1 2129 346
Eif3j2 -2616 7283
Eif3k -2270 -1119
Eif3l -593 3716
Eif3m -7076 6797
Eif4a1 -1988 2217
Eif4a2 -7548 5782
Eif4b -1893 4200
Eif4e -4688 6657
Eif4ebp1 1853 3169
Eif4g1 5626 -6388
Eif4h -2503 -1074
Fau 3642 5713
Pabpc1 -1115 6437
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098



CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
metric value
setSize 11
pMANOVA 0.00465
p.adjustMANOVA 0.0245
s.dist 0.551
s.LPS -0.432
s.OVA 0.342
p.LPS 0.013
p.OVA 0.0497




Top 20 genes
Gene LPS OVA
Prkar2b -8282 6950
Prkacb -8480 6485
Prkar1a -7928 6048
Creb1 -7585 5215
Calm1 -6747 5510
Prkx -7100 4041
Prkar1b -540 3037

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 -4526 -7621
Adcy8 658 -7261
Calm1 -6747 5510
Creb1 -7585 5215
Prkaca 1753 1
Prkacb -8480 6485
Prkar1a -7928 6048
Prkar1b -540 3037
Prkar2a 4256 6537
Prkar2b -8282 6950
Prkx -7100 4041



RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
metric value
setSize 125
pMANOVA 4.86e-24
p.adjustMANOVA 1.13e-21
s.dist 0.549
s.LPS 0.216
s.OVA 0.505
p.LPS 3.17e-05
p.OVA 1.81e-22




Top 20 genes
Gene LPS OVA
Timmdc1 7357 7319
Ndufa12 6998 7523
Ndufa10 5715 7438
Ndufaf1 5653 7100
Ndufa13 6592 5812
Ndufs2 4508 7474
Ndufaf2 4874 6154
Ndufaf6 4271 6561
Ndufs5 5914 4689
Sco2 4448 5969
Ucp2 3845 6673
Ndufa6 5352 4748
Taco1 5103 4947
Cox5b 4770 5257
Pm20d1 5121 4737
Surf1 3345 6962
Tmem126b 7101 3219
Ndufs6 5835 3821
Atp5b 2777 7881
Cox5a 2967 7056

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 608 1981
Atp5a1 -4979 7815
Atp5b 2777 7881
Atp5c1 -5844 7552
Atp5d 3989 1763
Atp5e 1649 1321
Atp5g1 5849 1062
Atp5g2 -6493 -3010
Atp5g3 3186 4173
Atp5h 1671 6021
Atp5j 4104 3760
Atp5j2 4355 1374
Atp5k 7163 360
Atp5l -831 1707
Atp5o 3993 3961
Atp5pb -1235 7179
Coq10a 3815 5334
Coq10b -3900 7972
Cox11 4944 -7059
Cox14 -791 -2266
Cox16 -5837 4702
Cox18 1918 4164
Cox19 6179 -4411
Cox20 494 5292
Cox4i1 2759 419
Cox5a 2967 7056
Cox5b 4770 5257
Cox6a1 533 6489
Cox6b1 3314 1740
Cox6c 1236 4892
Cox7a2l 1780 7722
Cox7b 367 4500
Cox7c 1266 5795
Cox8a 139 4534
Cyc1 1431 2316
Cycs -4448 7302
Dmac2l -2606 2799
Ecsit 1595 2336
Etfa -2755 3110
Etfb -1009 1992
Etfdh -5075 1102
Lrpprc -4802 -6897
mt-Atp6 -2868 6502
mt-Atp8 994 6358
mt-Co1 -2709 7832
mt-Co2 -2570 7453
mt-Co3 -1213 7241
mt-Cytb -1700 7368
mt-Nd1 -3437 7547
mt-Nd2 -4161 7398
mt-Nd3 -125 7652
mt-Nd4 -4483 7747
mt-Nd5 -4792 7472
mt-Nd6 -5972 7648
Ndufa1 4455 2808
Ndufa10 5715 7438
Ndufa11 2653 -920
Ndufa12 6998 7523
Ndufa13 6592 5812
Ndufa2 3298 -1358
Ndufa3 5066 -187
Ndufa4 647 6888
Ndufa5 1897 7071
Ndufa6 5352 4748
Ndufa7 1187 4511
Ndufa8 3953 1692
Ndufa9 214 -1151
Ndufab1 1653 5587
Ndufaf1 5653 7100
Ndufaf2 4874 6154
Ndufaf3 -710 -1141
Ndufaf4 -86 7830
Ndufaf5 2350 5651
Ndufaf6 4271 6561
Ndufaf7 952 -1197
Ndufb1 -3377 3408
Ndufb10 7581 314
Ndufb11 56 6442
Ndufb2 5312 1230
Ndufb3 6621 2486
Ndufb4 -1779 6522
Ndufb5 2197 7899
Ndufb6 2316 4162
Ndufb7 4405 1364
Ndufb8 3172 6153
Ndufb9 2239 6715
Ndufc1 575 7834
Ndufc2 -860 4791
Ndufs1 -1826 6346
Ndufs2 4508 7474
Ndufs3 -2761 5967
Ndufs4 2427 7475
Ndufs5 5914 4689
Ndufs6 5835 3821
Ndufs7 4329 2096
Ndufs8 2347 349
Ndufv1 5328 3456
Ndufv2 -2931 7852
Ndufv3 1927 201
Nubpl -4045 24
Pm20d1 5121 4737
Sco1 -8421 89
Sco2 4448 5969
Sdha -195 5190
Sdhb -706 4437
Sdhc 266 7696
Sdhd -1586 4980
Slc25a14 475 6786
Slc25a27 7307 -6515
Surf1 3345 6962
Taco1 5103 4947
Timmdc1 7357 7319
Tmem126b 7101 3219
Tmem186 333 -7228
Trap1 6956 -274
Ucp2 3845 6673
Ucp3 2554 3994
Uqcr10 2812 941
Uqcr11 2518 -883
Uqcrb 2530 7255
Uqcrc1 3152 822
Uqcrc2 -6454 5459
Uqcrfs1 -1373 3878
Uqcrh 1339 3287
Uqcrq 2765 4378



COLLAGEN CHAIN TRIMERIZATION

COLLAGEN CHAIN TRIMERIZATION
metric value
setSize 39
pMANOVA 9.52e-09
p.adjustMANOVA 3.36e-07
s.dist 0.543
s.LPS 0.423
s.OVA -0.34
p.LPS 4.8e-06
p.OVA 0.00024




Top 20 genes
Gene LPS OVA
Col12a1 7484 -6936
Col4a2 5545 -8019
Col26a1 7584 -5443
Col5a2 6824 -5299
Col2a1 6841 -4900
Col5a3 6553 -5014
Col27a1 7549 -4072
Col15a1 4514 -5174
Col6a2 6148 -2781
Col1a1 2552 -6406
Col6a3 4528 -3519
Col20a1 1833 -7961
Col6a1 5823 -2243
Col17a1 2348 -4166
Col16a1 7191 -959
Col9a3 3714 -1615
Col28a1 4668 -1079
Col6a5 2314 -1938
Col24a1 2944 -944
Col11a1 1206 -2090

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All member genes
LPS OVA
Col11a1 1206 -2090
Col11a2 7498 56
Col12a1 7484 -6936
Col13a1 7709 1905
Col14a1 -443 -4932
Col15a1 4514 -5174
Col16a1 7191 -959
Col17a1 2348 -4166
Col18a1 2997 366
Col19a1 -584 -7443
Col1a1 2552 -6406
Col1a2 7309 5847
Col20a1 1833 -7961
Col22a1 -5297 -7873
Col23a1 -3639 -8072
Col24a1 2944 -944
Col25a1 -5131 -4678
Col26a1 7584 -5443
Col27a1 7549 -4072
Col28a1 4668 -1079
Col2a1 6841 -4900
Col3a1 5848 1993
Col4a1 -836 -8183
Col4a2 5545 -8019
Col4a3 1820 -751
Col4a5 2442 175
Col5a1 -930 -7207
Col5a2 6824 -5299
Col5a3 6553 -5014
Col6a1 5823 -2243
Col6a2 6148 -2781
Col6a3 4528 -3519
Col6a5 2314 -1938
Col6a6 -5080 -3951
Col7a1 6652 703
Col8a1 -750 5025
Col8a2 -7493 -2433
Col9a2 7569 2976
Col9a3 3714 -1615



ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
metric value
setSize 10
pMANOVA 0.0121
p.adjustMANOVA 0.0523
s.dist 0.542
s.LPS 0.0136
s.OVA 0.542
p.LPS 0.94
p.OVA 0.00299




Top 20 genes
Gene LPS OVA
Got1 4368 6534
Naalad2 4078 5288
Folh1 2863 6635
Got2 2738 5946
Nat8l 1600 103

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -6224 7462
Aspa -7661 4930
Aspg 4189 -5649
Folh1 2863 6635
Got1 4368 6534
Got2 2738 5946
Naalad2 4078 5288
Nat8l 1600 103
Slc25a12 -2950 4506
Slc25a13 -6598 7142



SHC MEDIATED CASCADE FGFR3

SHC MEDIATED CASCADE FGFR3
metric value
setSize 12
pMANOVA 0.0066
p.adjustMANOVA 0.032
s.dist 0.541
s.LPS 0.214
s.OVA 0.497
p.LPS 0.198
p.OVA 0.0029




Top 20 genes
Gene LPS OVA
Fgfr3 7713 7853
Fgf1 3813 7424
Hras 4447 6110
Fgf9 3659 4354
Fgf2 2651 5894
Shc1 7110 2123
Fgf18 620 3640

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3813 7424
Fgf18 620 3640
Fgf2 2651 5894
Fgf5 5693 -1711
Fgf9 3659 4354
Fgfr3 7713 7853
Grb2 -3203 1149
Hras 4447 6110
Kras -6543 5579
Nras -4446 3851
Shc1 7110 2123
Sos1 -5907 674



SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
metric value
setSize 29
pMANOVA 1.52e-06
p.adjustMANOVA 3.63e-05
s.dist 0.54
s.LPS -0.216
s.OVA 0.495
p.LPS 0.0442
p.OVA 3.9e-06




Top 20 genes
Gene LPS OVA
Ube2d1 -7897 5949
Ube2d2a -7238 6097
Ube2l3 -5959 7066
Ube2a -6093 6498
Ube2w -7199 5275
Ube2g1 -4772 7663
Usp9x -7115 4817
Ube2b -6419 5229
Ube2e3 -5540 5773
Ube2q2 -5143 5291
Uchl3 -7805 3234
Ube2e1 -3586 5385
Uba6 -3042 4651
Ube2k -5377 2126
Ube2z -2081 4150
Ube2r2 -1047 7975
Ube2h -1763 2601
Cdc34 -124 3642

Click HERE to show all gene set members

All member genes
LPS OVA
Cdc34 -124 3642
Otulin 1050 5520
Rps27a 5721 6253
Uba1 1005 319
Uba52 3801 4656
Uba6 -3042 4651
Ubb 2566 4439
Ubc 3034 -673
Ube2a -6093 6498
Ube2b -6419 5229
Ube2d1 -7897 5949
Ube2d2a -7238 6097
Ube2e1 -3586 5385
Ube2e3 -5540 5773
Ube2g1 -4772 7663
Ube2g2 -128 -1818
Ube2h -1763 2601
Ube2k -5377 2126
Ube2l3 -5959 7066
Ube2q2 -5143 5291
Ube2r2 -1047 7975
Ube2s 23 837
Ube2t 4163 -677
Ube2w -7199 5275
Ube2z -2081 4150
Uchl3 -7805 3234
Usp5 2410 2438
Usp7 -882 -1717
Usp9x -7115 4817



SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
metric value
setSize 20
pMANOVA 0.000177
p.adjustMANOVA 0.00172
s.dist 0.535
s.LPS -0.00703
s.OVA 0.535
p.LPS 0.957
p.OVA 3.43e-05




Top 20 genes
Gene LPS OVA
Elovl4 -7080 6818
Acsl4 -6764 5738
Acsl3 -3920 7498
Elovl7 -7998 3624
Hacd2 -3847 7159
Acsl1 -4198 4259
Elovl2 -895 5553
Hsd17b12 -297 7821

Click HERE to show all gene set members

All member genes
LPS OVA
Acsbg1 7214 7513
Acsf3 -2701 -5397
Acsl1 -4198 4259
Acsl3 -3920 7498
Acsl4 -6764 5738
Acsl5 -5012 -954
Acsl6 433 3607
Elovl1 7795 8073
Elovl2 -895 5553
Elovl4 -7080 6818
Elovl5 403 7730
Elovl6 3612 1433
Elovl7 -7998 3624
Hacd1 2225 7375
Hacd2 -3847 7159
Hacd3 3734 7725
Hacd4 -3161 -252
Hsd17b12 -297 7821
Slc27a3 2678 -5073
Tecr 7167 4308



SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM
metric value
setSize 107
pMANOVA 2.87e-19
p.adjustMANOVA 2.78e-17
s.dist 0.534
s.LPS 0.332
s.OVA 0.418
p.LPS 3.09e-09
p.OVA 7.55e-14




Top 20 genes
Gene LPS OVA
Ahcy 7507 7405
Rps8 7269 7309
Rpl23a 6015 7526
Rps9 5470 7584
Rps29 6454 5764
Rps4x 5413 6683
Rps27a 5721 6253
Rpl23 5508 6486
Rpl6 5265 6716
Rps27l 4686 7434
Rpl37a 5424 6156
Rps25 4264 7814
Rpl24 4398 7497
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300
Rpl26 7183 3616
Rpl35 6121 4242

Click HERE to show all gene set members

All member genes
LPS OVA
Ahcy 7507 7405
Aimp1 1355 4825
Aimp2 6142 268
Cbs 2626 -568
Cth -1307 6923
Dars -7224 5278
Eef1e1 -1249 7098
Eefsec 40 -1800
Eprs 2558 863
Fau 3642 5713
Gsr -3324 5238
Hnmt -7289 7637
Iars 3348 -5243
Kars -281 7920
Lars -1610 -5960
Mars1 6048 -6552
Papss1 1035 6823
Papss2 -5682 5110
Pstk -3535 -5964
Qars -3239 1323
Rars -2988 1479
Rpl10 3681 -3707
Rpl10a 887 725
Rpl11 2278 5271
Rpl12 3715 -7459
Rpl13 3904 3220
Rpl13a 405 6090
Rpl14 3947 5501
Rpl15 -3300 3005
Rpl17 -2674 5569
Rpl18 1839 261
Rpl18a 3851 5321
Rpl19 2619 3550
Rpl21 2971 2664
Rpl22 727 5843
Rpl22l1 -3342 6907
Rpl23 5508 6486
Rpl23a 6015 7526
Rpl24 4398 7497
Rpl26 7183 3616
Rpl27 526 5180
Rpl27a 2840 2777
Rpl28 6951 830
Rpl29 -308 3645
Rpl3 2605 5902
Rpl30 3372 5167
Rpl31 3208 5659
Rpl32 3941 4603
Rpl34 -368 3497
Rpl35 6121 4242
Rpl35a 4654 5451
Rpl36 2400 -378
Rpl36a 919 4018
Rpl36al 2700 1803
Rpl37 5410 2939
Rpl37a 5424 6156
Rpl38 6478 3980
Rpl39 -2409 4847
Rpl4 866 6114
Rpl5 1278 6005
Rpl6 5265 6716
Rpl7 -1345 4991
Rpl7a 4402 2277
Rpl8 5073 2661
Rpl9 1473 5111
Rplp0 -305 5857
Rplp1 4410 -555
Rplp2 6464 772
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098
Sars 6473 110
Scly 906 -3430
Secisbp2 5871 -6789
Sephs2 -7561 3363
Sepsecs -6555 -5667
Txnrd1 -3548 610
Uba52 3801 4656



SIGNALING BY FGFR3 FUSIONS IN CANCER

SIGNALING BY FGFR3 FUSIONS IN CANCER
metric value
setSize 10
pMANOVA 0.0113
p.adjustMANOVA 0.0497
s.dist 0.534
s.LPS -0.187
s.OVA 0.5
p.LPS 0.306
p.OVA 0.00619




Top 20 genes
Gene LPS OVA
Kras -6543 5579
Gab1 -4803 7454
Frs2 -6071 4412
Nras -4446 3851
Sos1 -5907 674
Grb2 -3203 1149

Click HERE to show all gene set members

All member genes
LPS OVA
Fgfr3 7713 7853
Frs2 -6071 4412
Gab1 -4803 7454
Grb2 -3203 1149
Hras 4447 6110
Kras -6543 5579
Nras -4446 3851
Pik3ca 1378 6244
Pik3r1 -2748 -3930
Sos1 -5907 674



SCAVENGING BY CLASS A RECEPTORS

SCAVENGING BY CLASS A RECEPTORS
metric value
setSize 13
pMANOVA 0.00554
p.adjustMANOVA 0.0275
s.dist 0.532
s.LPS 0.446
s.OVA 0.291
p.LPS 0.0054
p.OVA 0.0691




Top 20 genes
Gene LPS OVA
Calr 7700 7865
Colec12 7152 7767
Col1a2 7309 5847
Apoe 5886 6055
Masp1 2774 7044
Hsp90b1 2500 6284
Col3a1 5848 1993
Ftl1 1716 4538

Click HERE to show all gene set members

All member genes
LPS OVA
Apoe 5886 6055
Calr 7700 7865
Col1a1 2552 -6406
Col1a2 7309 5847
Col3a1 5848 1993
Col4a1 -836 -8183
Col4a2 5545 -8019
Colec12 7152 7767
Fth1 -274 6240
Ftl1 1716 4538
Hsp90b1 2500 6284
Masp1 2774 7044
Scara5 -6113 -2249



SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
metric value
setSize 11
pMANOVA 0.00863
p.adjustMANOVA 0.0398
s.dist 0.532
s.LPS -0.53
s.OVA 0.0488
p.LPS 0.00234
p.OVA 0.779




Top 20 genes
Gene LPS OVA
Pik3c3 -6228 6553
Fig4 -4246 6474
Mtmr2 -7580 2591
Mtmr7 -5718 2935
Pik3c2a -7898 293

Click HERE to show all gene set members

All member genes
LPS OVA
Fig4 -4246 6474
Mtm1 392 -321
Mtmr2 -7580 2591
Mtmr4 -5564 -3684
Mtmr7 -5718 2935
Mtmr9 -5915 -2156
Pik3c2a -7898 293
Pik3c3 -6228 6553
Pik3r4 -3270 -2475
Pikfyve -8013 -6161
Vac14 635 -1753



ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
metric value
setSize 10
pMANOVA 0.0183
p.adjustMANOVA 0.0699
s.dist 0.53
s.LPS 0.231
s.OVA 0.477
p.LPS 0.206
p.OVA 0.00898




Top 20 genes
Gene LPS OVA
Calr 7700 7865
Nfyc 6347 6735
Hspa5 5094 7705
Ddit3 7454 4239
Xbp1 3568 7878
Hsp90b1 2500 6284

Click HERE to show all gene set members

All member genes
LPS OVA
Atf4 3752 -2098
Atf6 -7140 1162
Calr 7700 7865
Ddit3 7454 4239
Hsp90b1 2500 6284
Hspa5 5094 7705
Nfya -6484 -7153
Nfyb -8425 4900
Nfyc 6347 6735
Xbp1 3568 7878



ACTIVATION OF RAC1

ACTIVATION OF RAC1
metric value
setSize 13
pMANOVA 0.0032
p.adjustMANOVA 0.0184
s.dist 0.53
s.LPS -0.496
s.OVA 0.185
p.LPS 0.00195
p.OVA 0.247




Top 20 genes
Gene LPS OVA
Rac1 -7036 7670
Pak1 -7207 4464
Sos2 -6231 4047
Pak5 -5207 3531
Pak2 -2249 7894
Pak3 -3652 4264
Robo1 -7094 1594
Sos1 -5907 674
Nck1 -524 4851

Click HERE to show all gene set members

All member genes
LPS OVA
Nck1 -524 4851
Nck2 -1091 -3949
Pak1 -7207 4464
Pak2 -2249 7894
Pak3 -3652 4264
Pak4 -1892 -2843
Pak5 -5207 3531
Pak6 -2699 -7845
Rac1 -7036 7670
Robo1 -7094 1594
Slit2 -8699 -6961
Sos1 -5907 674
Sos2 -6231 4047



TRIGLYCERIDE CATABOLISM

TRIGLYCERIDE CATABOLISM
metric value
setSize 14
pMANOVA 0.00255
p.adjustMANOVA 0.0154
s.dist 0.529
s.LPS -0.0521
s.OVA 0.526
p.LPS 0.736
p.OVA 0.000655




Top 20 genes
Gene LPS OVA
Prkacb -8480 6485
Ppp1cb -5958 6601
Abhd5 -4555 6976
Gpd2 -7538 3428
Mgll -3056 868
Ppp1ca -155 4186

Click HERE to show all gene set members

All member genes
LPS OVA
Abhd5 -4555 6976
Cav1 4231 7990
Fabp3 1086 1580
Fabp5 5922 6214
Fabp7 -7505 -5723
Gpd2 -7538 3428
Lipe 3390 4695
Mgll -3056 868
Plin3 6767 7826
Ppp1ca -155 4186
Ppp1cb -5958 6601
Ppp1cc 1454 7034
Prkaca 1753 1
Prkacb -8480 6485



TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
metric value
setSize 15
pMANOVA 0.00265
p.adjustMANOVA 0.0159
s.dist 0.525
s.LPS 0.198
s.OVA 0.487
p.LPS 0.185
p.OVA 0.0011




Top 20 genes
Gene LPS OVA
Hif3a 7456 6469
Sall1 6659 6320
Klf4 6480 5941
Hhex 5761 6581
Epas1 6948 3971
Sox2 3257 7702
Stat3 6305 3857
Fgf2 2651 5894
Smad4 1312 6946

Click HERE to show all gene set members

All member genes
LPS OVA
Epas1 6948 3971
Fgf2 2651 5894
Foxp1 -3594 2369
Hhex 5761 6581
Hif3a 7456 6469
Klf4 6480 5941
Nr6a1 -2712 -5991
Pbx1 -2581 577
Sall1 6659 6320
Smad2 -7381 3104
Smad4 1312 6946
Sox2 3257 7702
Stat3 6305 3857
Tsc22d1 -7050 3274
Zic3 -6059 415



PI 3K CASCADE FGFR3

PI 3K CASCADE FGFR3
metric value
setSize 12
pMANOVA 0.0086
p.adjustMANOVA 0.0398
s.dist 0.525
s.LPS 0.188
s.OVA 0.491
p.LPS 0.26
p.OVA 0.00326




Top 20 genes
Gene LPS OVA
Fgfr3 7713 7853
Fgf1 3813 7424
Fgf9 3659 4354
Fgf2 2651 5894
Ptpn11 4272 3559
Pik3ca 1378 6244
Fgf18 620 3640

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3813 7424
Fgf18 620 3640
Fgf2 2651 5894
Fgf5 5693 -1711
Fgf9 3659 4354
Fgfr3 7713 7853
Frs2 -6071 4412
Gab1 -4803 7454
Grb2 -3203 1149
Pik3ca 1378 6244
Pik3r1 -2748 -3930
Ptpn11 4272 3559



SHC MEDIATED CASCADE FGFR4

SHC MEDIATED CASCADE FGFR4
metric value
setSize 10
pMANOVA 0.0176
p.adjustMANOVA 0.0684
s.dist 0.524
s.LPS 0.0837
s.OVA 0.517
p.LPS 0.647
p.OVA 0.00465




Top 20 genes
Gene LPS OVA
Fgf1 3813 7424
Hras 4447 6110
Fgf9 3659 4354
Fgf2 2651 5894
Shc1 7110 2123
Fgf18 620 3640

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3813 7424
Fgf18 620 3640
Fgf2 2651 5894
Fgf9 3659 4354
Grb2 -3203 1149
Hras 4447 6110
Kras -6543 5579
Nras -4446 3851
Shc1 7110 2123
Sos1 -5907 674



FRS MEDIATED FGFR3 SIGNALING

FRS MEDIATED FGFR3 SIGNALING
metric value
setSize 14
pMANOVA 0.00389
p.adjustMANOVA 0.0215
s.dist 0.523
s.LPS 0.151
s.OVA 0.501
p.LPS 0.327
p.OVA 0.00118




Top 20 genes
Gene LPS OVA
Fgfr3 7713 7853
Fgf1 3813 7424
Hras 4447 6110
Fgf9 3659 4354
Fgf2 2651 5894
Ptpn11 4272 3559
Frs3 4211 2456
Fgf18 620 3640

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3813 7424
Fgf18 620 3640
Fgf2 2651 5894
Fgf5 5693 -1711
Fgf9 3659 4354
Fgfr3 7713 7853
Frs2 -6071 4412
Frs3 4211 2456
Grb2 -3203 1149
Hras 4447 6110
Kras -6543 5579
Nras -4446 3851
Ptpn11 4272 3559
Sos1 -5907 674



COMPLEMENT CASCADE

COMPLEMENT CASCADE
metric value
setSize 22
pMANOVA 0.000231
p.adjustMANOVA 0.00217
s.dist 0.521
s.LPS 0.344
s.OVA 0.391
p.LPS 0.00524
p.OVA 0.00148




Top 20 genes
Gene LPS OVA
C1qb 6799 7122
C2 7641 5519
Serping1 6697 6016
C1qc 4296 7483
Clu 4694 6250
C1qa 2948 7430
Cfh 2523 7997
Masp1 2774 7044
C4b 4806 3711
Cr1l 1896 4805
Pros1 1017 7565
Cd81 862 7404
Cd55 761 4841

Click HERE to show all gene set members

All member genes
LPS OVA
C1qa 2948 7430
C1qb 6799 7122
C1qc 4296 7483
C2 7641 5519
C3ar1 -2324 5338
C4b 4806 3711
C8g 2961 -6233
Cd46 4159 -2940
Cd55 761 4841
Cd59b -1250 -2386
Cd81 862 7404
Cfb -7654 -6022
Cfh 2523 7997
Cfp 7564 -1864
Clu 4694 6250
Cr1l 1896 4805
Gzmm -541 -2227
Masp1 2774 7044
Masp2 5858 -2258
Pros1 1017 7565
Serping1 6697 6016
Vtn -4358 2287



FRS MEDIATED FGFR4 SIGNALING

FRS MEDIATED FGFR4 SIGNALING
metric value
setSize 12
pMANOVA 0.00796
p.adjustMANOVA 0.0374
s.dist 0.519
s.LPS 0.032
s.OVA 0.518
p.LPS 0.848
p.OVA 0.00188




Top 20 genes
Gene LPS OVA
Fgf1 3813 7424
Hras 4447 6110
Fgf9 3659 4354
Fgf2 2651 5894
Ptpn11 4272 3559
Frs3 4211 2456
Fgf18 620 3640

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3813 7424
Fgf18 620 3640
Fgf2 2651 5894
Fgf9 3659 4354
Frs2 -6071 4412
Frs3 4211 2456
Grb2 -3203 1149
Hras 4447 6110
Kras -6543 5579
Nras -4446 3851
Ptpn11 4272 3559
Sos1 -5907 674



CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
metric value
setSize 22
pMANOVA 0.000167
p.adjustMANOVA 0.00169
s.dist 0.519
s.LPS 0.0952
s.OVA 0.51
p.LPS 0.44
p.OVA 3.43e-05




Top 20 genes
Gene LPS OVA
Idh2 7463 6233
Suclg2 3744 7028
Suclg1 3076 5281
Nnt 2362 6529
Ogdh 2803 3777
Aco2 1817 4188
Fahd1 3260 1561
Mdh2 1031 3677
Sdhc 266 7696

Click HERE to show all gene set members

All member genes
LPS OVA
Aco2 1817 4188
Cs -3349 4952
Dld -7038 4578
Dlst 7422 -352
Fahd1 3260 1561
Fh1 -3924 5147
Idh2 7463 6233
Idh3a -3029 7845
Idh3b -152 -2449
Idh3g 3631 -2170
Mdh2 1031 3677
Me2 -3929 3443
Me3 -2878 55
Nnt 2362 6529
Ogdh 2803 3777
Sdha -195 5190
Sdhb -706 4437
Sdhc 266 7696
Sdhd -1586 4980
Sucla2 -3182 6857
Suclg1 3076 5281
Suclg2 3744 7028



CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING
metric value
setSize 16
pMANOVA 0.00182
p.adjustMANOVA 0.0117
s.dist 0.517
s.LPS -0.0766
s.OVA -0.511
p.LPS 0.596
p.OVA 0.000399




Top 20 genes
Gene LPS OVA
Plxna4 -4981 -7926
Crmp1 -4700 -6300
Cdk5r1 -8262 -2363
Plxna1 -1783 -7425
Plxna2 -2660 -4386
Gsk3b -5884 -1837
Nrp1 -1539 -3875

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk5 3038 -4307
Cdk5r1 -8262 -2363
Crmp1 -4700 -6300
Dpysl2 1167 -7144
Dpysl3 585 -5916
Dpysl4 3567 -6188
Dpysl5 2267 -5609
Fes 4946 -724
Fyn -3965 235
Gsk3b -5884 -1837
Nrp1 -1539 -3875
Plxna1 -1783 -7425
Plxna2 -2660 -4386
Plxna3 6888 -7836
Plxna4 -4981 -7926
Sema3a -6381 870



NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD
metric value
setSize 109
pMANOVA 4.07e-18
p.adjustMANOVA 3.39e-16
s.dist 0.513
s.LPS 0.353
s.OVA 0.372
p.LPS 2.01e-10
p.OVA 1.88e-11




Top 20 genes
Gene LPS OVA
Rps8 7269 7309
Rpl23a 6015 7526
Rps9 5470 7584
Rbm8a 5181 7524
Rps29 6454 5764
Rps4x 5413 6683
Rps27a 5721 6253
Rpl23 5508 6486
Rpl6 5265 6716
Rps27l 4686 7434
Rpl37a 5424 6156
Rps25 4264 7814
Rpl24 4398 7497
Rps3a1 4131 7050
Rps28 7413 3877
Rps26 5411 5204
Rps18 5147 5463
Rps19 5284 5300
Rpl26 7183 3616
Rpl35 6121 4242

Click HERE to show all gene set members

All member genes
LPS OVA
Casc3 5006 -8124
Dcp1a -2682 -3375
Eif4a3 4667 4491
Eif4g1 5626 -6388
Etf1 -6353 5115
Fau 3642 5713
Gspt1 -5185 4874
Gspt2 1399 -2982
Magoh -2101 -2345
Magohb 3204 4725
Ncbp1 627 4292
Ncbp2 1684 -2073
Pabpc1 -1115 6437
Pnrc2 -7671 6686
Ppp2ca -2506 5974
Ppp2r1a 137 5751
Ppp2r2a -4836 7646
Rbm8a 5181 7524
Rnps1 1850 1663
Rpl10 3681 -3707
Rpl10a 887 725
Rpl11 2278 5271
Rpl12 3715 -7459
Rpl13 3904 3220
Rpl13a 405 6090
Rpl14 3947 5501
Rpl15 -3300 3005
Rpl17 -2674 5569
Rpl18 1839 261
Rpl18a 3851 5321
Rpl19 2619 3550
Rpl21 2971 2664
Rpl22 727 5843
Rpl22l1 -3342 6907
Rpl23 5508 6486
Rpl23a 6015 7526
Rpl24 4398 7497
Rpl26 7183 3616
Rpl27 526 5180
Rpl27a 2840 2777
Rpl28 6951 830
Rpl29 -308 3645
Rpl3 2605 5902
Rpl30 3372 5167
Rpl31 3208 5659
Rpl32 3941 4603
Rpl34 -368 3497
Rpl35 6121 4242
Rpl35a 4654 5451
Rpl36 2400 -378
Rpl36a 919 4018
Rpl36al 2700 1803
Rpl37 5410 2939
Rpl37a 5424 6156
Rpl38 6478 3980
Rpl39 -2409 4847
Rpl4 866 6114
Rpl5 1278 6005
Rpl6 5265 6716
Rpl7 -1345 4991
Rpl7a 4402 2277
Rpl8 5073 2661
Rpl9 1473 5111
Rplp0 -305 5857
Rplp1 4410 -555
Rplp2 6464 772
Rps10 2927 1096
Rps11 3856 3501
Rps12 1202 -529
Rps13 5831 2141
Rps14 3092 -1425
Rps15 2974 681
Rps15a -1928 -367
Rps16 3363 1896
Rps17 3862 2720
Rps18 5147 5463
Rps19 5284 5300
Rps2 5568 1407
Rps20 -237 5390
Rps21 5587 3173
Rps23 865 6778
Rps24 3022 6357
Rps25 4264 7814
Rps26 5411 5204
Rps27 1642 2194
Rps27a 5721 6253
Rps27l 4686 7434
Rps28 7413 3877
Rps29 6454 5764
Rps3 -767 1372
Rps3a1 4131 7050
Rps4x 5413 6683
Rps5 2207 4922
Rps6 3673 2037
Rps7 2681 6267
Rps8 7269 7309
Rps9 5470 7584
Rpsa 2565 3098
Smg1 -2419 -8045
Smg5 2158 -6468
Smg6 -4231 -8330
Smg7 -3525 -5976
Smg8 -2111 3842
Smg9 1677 -4675
Uba52 3801 4656
Upf1 4553 -7635
Upf2 5788 -5907
Upf3a 7289 -3312
Upf3b 5678 2082



PI 3K CASCADE FGFR4

PI 3K CASCADE FGFR4
metric value
setSize 10
pMANOVA 0.0203
p.adjustMANOVA 0.0751
s.dist 0.512
s.LPS 0.0519
s.OVA 0.51
p.LPS 0.776
p.OVA 0.00526




Top 20 genes
Gene LPS OVA
Fgf1 3813 7424
Fgf9 3659 4354
Fgf2 2651 5894
Ptpn11 4272 3559
Pik3ca 1378 6244
Fgf18 620 3640

Click HERE to show all gene set members

All member genes
LPS OVA
Fgf1 3813 7424
Fgf18 620 3640
Fgf2 2651 5894
Fgf9 3659 4354
Frs2 -6071 4412
Gab1 -4803 7454
Grb2 -3203 1149
Pik3ca 1378 6244
Pik3r1 -2748 -3930
Ptpn11 4272 3559



BLOOD GROUP SYSTEMS BIOSYNTHESIS

BLOOD GROUP SYSTEMS BIOSYNTHESIS
metric value
setSize 13
pMANOVA 0.00516
p.adjustMANOVA 0.0264
s.dist 0.51
s.LPS -0.125
s.OVA 0.495
p.LPS 0.435
p.OVA 0.00201




Top 20 genes
Gene LPS OVA
B3galt1 -7820 5264
Fut9 -7504 5205
B3galt2 -5774 6434
B3galt5 -4695 6492
St3gal6 -1938 5356
Fut10 -1390 3959
Fut2 -1200 2104
St6galnac6 -701 3135

Click HERE to show all gene set members

All member genes
LPS OVA
B3galt1 -7820 5264
B3galt2 -5774 6434
B3galt4 -8291 -1976
B3galt5 -4695 6492
Fut10 -1390 3959
Fut11 6253 4650
Fut2 -1200 2104
Fut4 544 838
Fut9 -7504 5205
St3gal3 6212 1136
St3gal4 6713 8048
St3gal6 -1938 5356
St6galnac6 -701 3135



G BETA GAMMA SIGNALLING THROUGH CDC42

G BETA GAMMA SIGNALLING THROUGH CDC42
metric value
setSize 18
pMANOVA 0.000593
p.adjustMANOVA 0.0047
s.dist 0.51
s.LPS -0.223
s.OVA 0.459
p.LPS 0.102
p.OVA 0.000754




Top 20 genes
Gene LPS OVA
Gng12 -6342 7762
Cdc42 -6734 6326
Gng10 -5606 7084
Pak1 -7207 4464
Gnb4 -8083 2628
Gng2 -8001 1552
Gng5 -818 7006
Gnb1 -6678 592
Gng13 -3686 918
Gng11 -360 6592
Gng7 -405 5101
Gnb2 -173 1359

Click HERE to show all gene set members

All member genes
LPS OVA
Arhgef6 -5440 -4409
Cdc42 -6734 6326
Gnb1 -6678 592
Gnb2 -173 1359
Gnb4 -8083 2628
Gnb5 2322 6656
Gng10 -5606 7084
Gng11 -360 6592
Gng12 -6342 7762
Gng13 -3686 918
Gng2 -8001 1552
Gng3 4649 4211
Gng4 688 2010
Gng5 -818 7006
Gng7 -405 5101
Gng8 5762 2068
Gngt2 4501 2828
Pak1 -7207 4464



FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
metric value
setSize 18
pMANOVA 0.00118
p.adjustMANOVA 0.00837
s.dist 0.509
s.LPS 0.157
s.OVA 0.484
p.LPS 0.249
p.OVA 0.000373




Top 20 genes
Gene LPS OVA
Atp5b 2777 7881
Atp5o 3993 3961
Atp5j 4104 3760
Atp5g3 3186 4173
Atp5h 1671 6021
Atp5d 3989 1763
mt-Atp8 994 6358
Atp5g1 5849 1062
Atp5j2 4355 1374
Atp5k 7163 360
Atp5e 1649 1321

Click HERE to show all gene set members

All member genes
LPS OVA
Atp5a1 -4979 7815
Atp5b 2777 7881
Atp5c1 -5844 7552
Atp5d 3989 1763
Atp5e 1649 1321
Atp5g1 5849 1062
Atp5g2 -6493 -3010
Atp5g3 3186 4173
Atp5h 1671 6021
Atp5j 4104 3760
Atp5j2 4355 1374
Atp5k 7163 360
Atp5l -831 1707
Atp5o 3993 3961
Atp5pb -1235 7179
Dmac2l -2606 2799
mt-Atp6 -2868 6502
mt-Atp8 994 6358



PLATELET SENSITIZATION BY LDL

PLATELET SENSITIZATION BY LDL
metric value
setSize 15
pMANOVA 0.00341
p.adjustMANOVA 0.0192
s.dist 0.505
s.LPS 0.0548
s.OVA 0.502
p.LPS 0.713
p.OVA 0.000757




Top 20 genes
Gene LPS OVA
Ppp2r5b 7586 7671
Ptpn6 7460 5262
Ppp2r5d 5356 6041
Ptpn11 4272 3559
Pla2g4a 2008 7127
Ppp2r1a 137 5751

Click HERE to show all gene set members

All member genes
LPS OVA
Lrp8 -934 -8372
Mapk14 2007 -4067
Pecam1 -7440 6257
Pla2g4a 2008 7127
Ppp2ca -2506 5974
Ppp2cb -7982 7855
Ppp2r1a 137 5751
Ppp2r1b -932 -3510
Ppp2r5a -1874 7783
Ppp2r5b 7586 7671
Ppp2r5c -5782 6187
Ppp2r5d 5356 6041
Ppp2r5e -1666 5852
Ptpn11 4272 3559
Ptpn6 7460 5262



RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
metric value
setSize 10
pMANOVA 0.0187
p.adjustMANOVA 0.0705
s.dist 0.505
s.LPS -0.141
s.OVA 0.485
p.LPS 0.44
p.OVA 0.00795




Top 20 genes
Gene LPS OVA
Rhobtb3 -7960 7460
Cul3 -7372 7408
Vhl -7890 5202
Rab9b -3608 4709
Lrrc41 -5186 2725
Rab9 -478 6856

Click HERE to show all gene set members

All member genes
LPS OVA
Ccne1 2893 -6901
Cul3 -7372 7408
Hgs 4706 611
Htr7 1747 2243
Lrrc41 -5186 2725
Plin3 6767 7826
Rab9 -478 6856
Rab9b -3608 4709
Rhobtb3 -7960 7460
Vhl -7890 5202



GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
metric value
setSize 12
pMANOVA 0.0158
p.adjustMANOVA 0.0632
s.dist 0.491
s.LPS 0.186
s.OVA 0.455
p.LPS 0.266
p.OVA 0.00637




Top 20 genes
Gene LPS OVA
Rps27a 5721 6253
Gys1 7521 3079
Uba52 3801 4656
Nhlrc1 2572 4999
Ubb 2566 4439
Gaa 452 3597
Ppp1r3c 175 4961

Click HERE to show all gene set members

All member genes
LPS OVA
Epm2a -8649 -6605
G6pc3 -100 3447
Gaa 452 3597
Gbe1 -3440 7407
Gyg -912 7240
Gys1 7521 3079
Nhlrc1 2572 4999
Ppp1r3c 175 4961
Rps27a 5721 6253
Uba52 3801 4656
Ubb 2566 4439
Ubc 3034 -673



SEROTONIN RECEPTORS

SEROTONIN RECEPTORS
metric value
setSize 10
pMANOVA 0.0208
p.adjustMANOVA 0.0764
s.dist 0.491
s.LPS -0.393
s.OVA 0.294
p.LPS 0.0313
p.OVA 0.107




Top 20 genes
Gene LPS OVA
Htr2a -7122 6384
Htr2c -6679 4036
Htr1d -5039 3421
Htr1f -2692 3773

Click HERE to show all gene set members

All member genes
LPS OVA
Htr1a 57 3366
Htr1b 1177 5911
Htr1d -5039 3421
Htr1f -2692 3773
Htr2a -7122 6384
Htr2c -6679 4036
Htr4 -8665 -2931
Htr5a -7168 -1892
Htr6 -2860 -1931
Htr7 1747 2243



THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 172
pMANOVA 1.2e-26
p.adjustMANOVA 4.68e-24
s.dist 0.491
s.LPS 0.14
s.OVA 0.471
p.LPS 0.00159
p.OVA 1.72e-26




Top 20 genes
Gene LPS OVA
Timmdc1 7357 7319
Ndufa12 6998 7523
Idh2 7463 6233
Ndufa10 5715 7438
Ndufaf1 5653 7100
Ndufa13 6592 5812
Rxra 5738 6255
Ldhb 5971 5888
Ndufs2 4508 7474
Ndufaf2 4874 6154
Ndufaf6 4271 6561
Ndufs5 5914 4689
Sco2 4448 5969
Suclg2 3744 7028
Ucp2 3845 6673
Ndufa6 5352 4748
Taco1 5103 4947
Cox5b 4770 5257
Pm20d1 5121 4737
Surf1 3345 6962

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 608 1981
Aco2 1817 4188
Adhfe1 -4171 4446
Atp5a1 -4979 7815
Atp5b 2777 7881
Atp5c1 -5844 7552
Atp5d 3989 1763
Atp5e 1649 1321
Atp5g1 5849 1062
Atp5g2 -6493 -3010
Atp5g3 3186 4173
Atp5h 1671 6021
Atp5j 4104 3760
Atp5j2 4355 1374
Atp5k 7163 360
Atp5l -831 1707
Atp5o 3993 3961
Atp5pb -1235 7179
Bsg -2241 3328
Coq10a 3815 5334
Coq10b -3900 7972
Cox11 4944 -7059
Cox14 -791 -2266
Cox16 -5837 4702
Cox18 1918 4164
Cox19 6179 -4411
Cox20 494 5292
Cox4i1 2759 419
Cox5a 2967 7056
Cox5b 4770 5257
Cox6a1 533 6489
Cox6b1 3314 1740
Cox6c 1236 4892
Cox7a2l 1780 7722
Cox7b 367 4500
Cox7c 1266 5795
Cox8a 139 4534
Cs -3349 4952
Cyc1 1431 2316
Cycs -4448 7302
D2hgdh -1034 -1142
Dlat -460 7557
Dld -7038 4578
Dlst 7422 -352
Dmac2l -2606 2799
Ecsit 1595 2336
Etfa -2755 3110
Etfb -1009 1992
Etfdh -5075 1102
Fahd1 3260 1561
Fh1 -3924 5147
Glo1 -64 6679
Gstz1 -1247 -4277
Hagh 3304 1620
Idh2 7463 6233
Idh3a -3029 7845
Idh3b -152 -2449
Idh3g 3631 -2170
L2hgdh -3603 -1909
Ldha -3157 -113
Ldhb 5971 5888
Lrpprc -4802 -6897
Mdh2 1031 3677
Me1 -1764 5724
Me2 -3929 3443
Me3 -2878 55
Mpc1 -92 7173
Mpc2 -2652 5317
mt-Atp6 -2868 6502
mt-Atp8 994 6358
mt-Co1 -2709 7832
mt-Co2 -2570 7453
mt-Co3 -1213 7241
mt-Cytb -1700 7368
mt-Nd1 -3437 7547
mt-Nd2 -4161 7398
mt-Nd3 -125 7652
mt-Nd4 -4483 7747
mt-Nd5 -4792 7472
mt-Nd6 -5972 7648
Ndufa1 4455 2808
Ndufa10 5715 7438
Ndufa11 2653 -920
Ndufa12 6998 7523
Ndufa13 6592 5812
Ndufa2 3298 -1358
Ndufa3 5066 -187
Ndufa4 647 6888
Ndufa5 1897 7071
Ndufa6 5352 4748
Ndufa7 1187 4511
Ndufa8 3953 1692
Ndufa9 214 -1151
Ndufab1 1653 5587
Ndufaf1 5653 7100
Ndufaf2 4874 6154
Ndufaf3 -710 -1141
Ndufaf4 -86 7830
Ndufaf5 2350 5651
Ndufaf6 4271 6561
Ndufaf7 952 -1197
Ndufb1 -3377 3408
Ndufb10 7581 314
Ndufb11 56 6442
Ndufb2 5312 1230
Ndufb3 6621 2486
Ndufb4 -1779 6522
Ndufb5 2197 7899
Ndufb6 2316 4162
Ndufb7 4405 1364
Ndufb8 3172 6153
Ndufb9 2239 6715
Ndufc1 575 7834
Ndufc2 -860 4791
Ndufs1 -1826 6346
Ndufs2 4508 7474
Ndufs3 -2761 5967
Ndufs4 2427 7475
Ndufs5 5914 4689
Ndufs6 5835 3821
Ndufs7 4329 2096
Ndufs8 2347 349
Ndufv1 5328 3456
Ndufv2 -2931 7852
Ndufv3 1927 201
Nnt 2362 6529
Nubpl -4045 24
Ogdh 2803 3777
Pdha1 -458 7222
Pdhb -1925 5112
Pdhx -6801 4811
Pdk1 -5355 -8266
Pdk2 294 328
Pdk3 -3876 7928
Pdk4 -7648 5953
Pdp1 -670 5797
Pdp2 -7246 -6912
Pdpr -3295 -2910
Pm20d1 5121 4737
Ppard 5742 3245
Rxra 5738 6255
Sco1 -8421 89
Sco2 4448 5969
Sdha -195 5190
Sdhb -706 4437
Sdhc 266 7696
Sdhd -1586 4980
Slc16a1 -8745 4019
Slc16a3 -3570 -1969
Slc16a8 -8439 -7477
Slc25a14 475 6786
Slc25a27 7307 -6515
Sucla2 -3182 6857
Suclg1 3076 5281
Suclg2 3744 7028
Surf1 3345 6962
Taco1 5103 4947
Timmdc1 7357 7319
Tmem126b 7101 3219
Tmem186 333 -7228
Trap1 6956 -274
Ucp2 3845 6673
Ucp3 2554 3994
Uqcr10 2812 941
Uqcr11 2518 -883
Uqcrb 2530 7255
Uqcrc1 3152 822
Uqcrc2 -6454 5459
Uqcrfs1 -1373 3878
Uqcrh 1339 3287
Uqcrq 2765 4378
Vdac1 1584 5837



DARPP 32 EVENTS

DARPP 32 EVENTS
metric value
setSize 23
pMANOVA 0.00017
p.adjustMANOVA 0.0017
s.dist 0.488
s.LPS -0.201
s.OVA 0.445
p.LPS 0.0954
p.OVA 0.000222




Top 20 genes
Gene LPS OVA
Ppp2cb -7982 7855
Prkar2b -8282 6950
Prkacb -8480 6485
Ppp3r1 -7651 6885
Ppp3cb -7423 6481
Prkar1a -7928 6048
Calm1 -6747 5510
Ppp3ca -4157 6737
Pde4b -4169 5571
Ppp2ca -2506 5974
Prkar1b -540 3037
Ppp1ca -155 4186

Click HERE to show all gene set members

All member genes
LPS OVA
Calm1 -6747 5510
Cdk5 3038 -4307
Pde4a 5033 -424
Pde4b -4169 5571
Pde4c 7631 787
Pde4d -4825 -3792
Ppp1ca -155 4186
Ppp1r1b 925 4989
Ppp2ca -2506 5974
Ppp2cb -7982 7855
Ppp2r1a 137 5751
Ppp2r1b -932 -3510
Ppp2r5d 5356 6041
Ppp3ca -4157 6737
Ppp3cb -7423 6481
Ppp3cc -5405 -3732
Ppp3r1 -7651 6885
Prkaca 1753 1
Prkacb -8480 6485
Prkar1a -7928 6048
Prkar1b -540 3037
Prkar2a 4256 6537
Prkar2b -8282 6950



ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON

ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
metric value
setSize 16
pMANOVA 0.00462
p.adjustMANOVA 0.0245
s.dist 0.486
s.LPS 0.437
s.OVA 0.212
p.LPS 0.00246
p.OVA 0.142




Top 20 genes
Gene LPS OVA
Cd14 6394 7711
Ticam2 6672 5844
Rps27a 5721 6253
Uba52 3801 4656
Tank 2704 6341
Tlr4 3818 4141
Ptpn11 4272 3559
Ticam1 4213 2893
Ubb 2566 4439
Ikbke 4860 1022

Click HERE to show all gene set members

All member genes
LPS OVA
Cd14 6394 7711
Ikbke 4860 1022
Irf3 7038 -2565
Irf7 -8747 1140
Ptpn11 4272 3559
Rps27a 5721 6253
Sarm1 -164 -6600
Tank 2704 6341
Tbk1 640 -6084
Ticam1 4213 2893
Ticam2 6672 5844
Tlr4 3818 4141
Traf3 3450 -7165
Uba52 3801 4656
Ubb 2566 4439
Ubc 3034 -673



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report