date generated: 2024-06-05

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik 0.2684894
0610009E02Rik -0.7521235
0610009L18Rik -1.1838923
0610010K14Rik -0.0433030
0610012G03Rik -0.1930476
0610030E20Rik 1.0496464

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16805
duplicated_genes_present 0
num_profile_genes_in_sets 8283
num_profile_genes_not_in_sets 8522

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 437
num_genesets_included 1167

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
MET ACTIVATES RAP1 AND RAC1 11 1.04e-03 -0.571 2.95e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.14e-03 -0.535 5.10e-02
ACTIVATION OF RAC1 13 1.76e-03 -0.501 4.46e-02
INITIAL TRIGGERING OF COMPLEMENT 10 1.00e-02 0.470 1.54e-01
EUKARYOTIC TRANSLATION ELONGATION 87 1.84e-12 0.437 2.14e-09
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.22e-02 -0.437 1.71e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 6.79e-03 0.434 1.24e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 2.77e-03 0.432 6.34e-02
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 9.08e-04 0.429 2.65e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 9.21e-03 0.417 1.47e-01
SCAVENGING BY CLASS A RECEPTORS 14 7.54e-03 0.412 1.31e-01
SEROTONIN RECEPTORS 10 2.91e-02 -0.398 2.95e-01
COLLAGEN CHAIN TRIMERIZATION 40 1.46e-05 0.396 8.09e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 6.13e-03 -0.396 1.14e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.88e-02 0.376 2.27e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 3.70e-10 0.374 7.86e-08
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.77e-02 0.367 2.91e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 9.62e-07 0.357 7.01e-05
NONSENSE MEDIATED DECAY NMD 109 4.04e-10 0.347 7.86e-08
AGGREPHAGY 35 5.19e-04 0.339 1.64e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 6.37e-02 -0.339 4.48e-01
COMPLEMENT CASCADE 22 6.01e-03 0.338 1.14e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 6.03e-03 0.338 1.14e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 1.32e-02 -0.337 1.79e-01
CROSSLINKING OF COLLAGEN FIBRILS 14 2.90e-02 0.337 2.95e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 4.67e-03 0.334 9.74e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 8.52e-03 -0.332 1.40e-01
SELENOAMINO ACID METABOLISM 108 2.66e-09 0.332 4.44e-07
P75NTR SIGNALS VIA NF KB 16 2.50e-02 0.324 2.72e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.25e-02 -0.320 2.57e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 8.05e-02 -0.319 4.79e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 8.15e-05 0.319 3.52e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.54e-08 0.318 1.79e-06
FERTILIZATION 12 5.67e-02 0.318 4.33e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.36e-02 0.317 2.62e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 4.77e-02 0.317 3.87e-01
CD28 DEPENDENT VAV1 PATHWAY 11 6.86e-02 -0.317 4.48e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.07e-02 -0.315 4.49e-01
INSULIN PROCESSING 24 7.86e-03 -0.313 1.33e-01
RHO GTPASES ACTIVATE ROCKS 19 1.83e-02 0.313 2.27e-01
PEXOPHAGY 11 7.53e-02 0.310 4.68e-01
TIGHT JUNCTION INTERACTIONS 18 2.31e-02 -0.309 2.59e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 2.04e-02 -0.307 2.36e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 5.52e-02 0.307 4.26e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 8.03e-02 -0.305 4.79e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.34e-05 0.303 1.14e-03
COLLAGEN DEGRADATION 51 1.86e-04 0.303 7.24e-03
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 7.02e-02 -0.302 4.49e-01
CGMP EFFECTS 15 4.31e-02 -0.302 3.70e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 6.01e-02 0.301 4.47e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
MET ACTIVATES RAP1 AND RAC1 11 1.04e-03 -5.71e-01 2.95e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.14e-03 -5.35e-01 5.10e-02
ACTIVATION OF RAC1 13 1.76e-03 -5.01e-01 4.46e-02
INITIAL TRIGGERING OF COMPLEMENT 10 1.00e-02 4.70e-01 1.54e-01
EUKARYOTIC TRANSLATION ELONGATION 87 1.84e-12 4.37e-01 2.14e-09
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.22e-02 -4.37e-01 1.71e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 6.79e-03 4.34e-01 1.24e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 2.77e-03 4.32e-01 6.34e-02
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 9.08e-04 4.29e-01 2.65e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 9.21e-03 4.17e-01 1.47e-01
SCAVENGING BY CLASS A RECEPTORS 14 7.54e-03 4.12e-01 1.31e-01
SEROTONIN RECEPTORS 10 2.91e-02 -3.98e-01 2.95e-01
COLLAGEN CHAIN TRIMERIZATION 40 1.46e-05 3.96e-01 8.09e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 6.13e-03 -3.96e-01 1.14e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.88e-02 3.76e-01 2.27e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 3.70e-10 3.74e-01 7.86e-08
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.77e-02 3.67e-01 2.91e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 9.62e-07 3.57e-01 7.01e-05
NONSENSE MEDIATED DECAY NMD 109 4.04e-10 3.47e-01 7.86e-08
AGGREPHAGY 35 5.19e-04 3.39e-01 1.64e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 6.37e-02 -3.39e-01 4.48e-01
COMPLEMENT CASCADE 22 6.01e-03 3.38e-01 1.14e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 6.03e-03 3.38e-01 1.14e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 1.32e-02 -3.37e-01 1.79e-01
CROSSLINKING OF COLLAGEN FIBRILS 14 2.90e-02 3.37e-01 2.95e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 4.67e-03 3.34e-01 9.74e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 8.52e-03 -3.32e-01 1.40e-01
SELENOAMINO ACID METABOLISM 108 2.66e-09 3.32e-01 4.44e-07
P75NTR SIGNALS VIA NF KB 16 2.50e-02 3.24e-01 2.72e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.25e-02 -3.20e-01 2.57e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 8.05e-02 -3.19e-01 4.79e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 8.15e-05 3.19e-01 3.52e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.54e-08 3.18e-01 1.79e-06
FERTILIZATION 12 5.67e-02 3.18e-01 4.33e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.36e-02 3.17e-01 2.62e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 4.77e-02 3.17e-01 3.87e-01
CD28 DEPENDENT VAV1 PATHWAY 11 6.86e-02 -3.17e-01 4.48e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.07e-02 -3.15e-01 4.49e-01
INSULIN PROCESSING 24 7.86e-03 -3.13e-01 1.33e-01
RHO GTPASES ACTIVATE ROCKS 19 1.83e-02 3.13e-01 2.27e-01
PEXOPHAGY 11 7.53e-02 3.10e-01 4.68e-01
TIGHT JUNCTION INTERACTIONS 18 2.31e-02 -3.09e-01 2.59e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 2.04e-02 -3.07e-01 2.36e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 5.52e-02 3.07e-01 4.26e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 8.03e-02 -3.05e-01 4.79e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.34e-05 3.03e-01 1.14e-03
COLLAGEN DEGRADATION 51 1.86e-04 3.03e-01 7.24e-03
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 7.02e-02 -3.02e-01 4.49e-01
CGMP EFFECTS 15 4.31e-02 -3.02e-01 3.70e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 6.01e-02 3.01e-01 4.47e-01
COLLAGEN FORMATION 79 3.86e-06 3.01e-01 2.65e-04
ACTIVATION OF SMO 16 3.76e-02 3.00e-01 3.47e-01
EUKARYOTIC TRANSLATION INITIATION 114 3.26e-08 3.00e-01 2.93e-06
JOSEPHIN DOMAIN DUBS 11 8.79e-02 2.97e-01 4.83e-01
CYTOSOLIC TRNA AMINOACYLATION 24 1.18e-02 2.97e-01 1.71e-01
PROCESSING AND ACTIVATION OF SUMO 10 1.05e-01 -2.96e-01 5.27e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 11 9.00e-02 2.95e-01 4.85e-01
REGULATION OF IFNG SIGNALING 13 6.66e-02 -2.94e-01 4.48e-01
INTERFERON ALPHA BETA SIGNALING 52 2.53e-04 -2.93e-01 9.24e-03
ECM PROTEOGLYCANS 65 4.36e-05 2.93e-01 2.04e-03
GLUTAMATE AND GLUTAMINE METABOLISM 13 6.74e-02 2.93e-01 4.48e-01
PYRIMIDINE SALVAGE 10 1.12e-01 -2.90e-01 5.39e-01
COMPLEX I BIOGENESIS 56 1.82e-04 2.89e-01 7.24e-03
MET ACTIVATES PTK2 SIGNALING 29 7.17e-03 2.89e-01 1.29e-01
SMOOTH MUSCLE CONTRACTION 33 4.27e-03 2.87e-01 9.07e-02
INTERLEUKIN 37 SIGNALING 19 3.16e-02 2.85e-01 3.05e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 5.89e-02 -2.82e-01 4.40e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 6.85e-02 2.81e-01 4.48e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 5.93e-03 2.81e-01 1.14e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 6.89e-02 -2.81e-01 4.48e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 8.11e-02 2.79e-01 4.80e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 9.80e-02 2.76e-01 5.06e-01
MRNA SPLICING 188 8.39e-11 2.75e-01 2.45e-08
ELASTIC FIBRE FORMATION 37 3.88e-03 2.74e-01 8.55e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.35e-01 -2.73e-01 5.59e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 1.02e-01 2.72e-01 5.21e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.55e-02 -2.72e-01 3.31e-01
PYRIMIDINE CATABOLISM 10 1.37e-01 -2.71e-01 5.59e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 1.05e-01 -2.70e-01 5.28e-01
CS DS DEGRADATION 14 8.37e-02 2.67e-01 4.83e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 4.44e-04 2.64e-01 1.44e-02
CELL CELL JUNCTION ORGANIZATION 50 1.31e-03 -2.63e-01 3.55e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 1.21e-08 2.61e-01 1.57e-06
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 1.18e-01 -2.60e-01 5.53e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.14e-02 2.59e-01 3.05e-01
PROLONGED ERK ACTIVATION EVENTS 14 9.57e-02 -2.57e-01 4.99e-01
HSF1 DEPENDENT TRANSACTIVATION 34 9.64e-03 2.57e-01 1.50e-01
P75NTR REGULATES AXONOGENESIS 10 1.60e-01 -2.56e-01 6.00e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.25e-01 -2.56e-01 5.55e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.48e-01 -2.52e-01 5.77e-01
DISEASES OF DNA REPAIR 11 1.53e-01 2.49e-01 5.85e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 1.56e-01 2.47e-01 5.90e-01
RHO GTPASES ACTIVATE CIT 18 7.04e-02 2.46e-01 4.49e-01
SYNDECAN INTERACTIONS 26 3.06e-02 2.45e-01 3.05e-01
RMTS METHYLATE HISTONE ARGININES 42 6.13e-03 2.44e-01 1.14e-01
RAP1 SIGNALLING 15 1.01e-01 -2.44e-01 5.19e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.82e-01 -2.44e-01 6.38e-01
BIOTIN TRANSPORT AND METABOLISM 11 1.64e-01 2.43e-01 6.06e-01
CELLULAR RESPONSE TO STARVATION 145 5.15e-07 2.42e-01 4.29e-05
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 1.86e-01 -2.42e-01 6.43e-01
CHAPERONE MEDIATED AUTOPHAGY 20 6.18e-02 2.41e-01 4.48e-01
AMINE LIGAND BINDING RECEPTORS 31 2.03e-02 -2.41e-01 2.36e-01
ATTENUATION PHASE 24 4.16e-02 2.40e-01 3.60e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 5.41e-02 2.37e-01 4.24e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 6.65e-02 -2.37e-01 4.48e-01
RAB GERANYLGERANYLATION 57 1.99e-03 -2.37e-01 4.94e-02
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 1.75e-01 2.36e-01 6.24e-01
SIGNALING BY KIT IN DISEASE 20 6.80e-02 -2.36e-01 4.48e-01
POLO LIKE KINASE MEDIATED EVENTS 13 1.44e-01 2.34e-01 5.71e-01
REPRESSION OF WNT TARGET GENES 14 1.30e-01 2.34e-01 5.59e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 8.65e-02 -2.33e-01 4.83e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 1.87e-02 -2.33e-01 2.27e-01
RRNA PROCESSING 194 3.03e-08 2.31e-01 2.93e-06
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.15e-02 -2.31e-01 1.71e-01
DISEASES OF MITOTIC CELL CYCLE 37 1.52e-02 -2.31e-01 1.95e-01
REGULATION OF KIT SIGNALING 16 1.14e-01 -2.28e-01 5.39e-01
CD28 CO STIMULATION 30 3.08e-02 -2.28e-01 3.05e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 18 9.45e-02 -2.28e-01 4.97e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 8.60e-02 -2.28e-01 4.83e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.13e-01 2.28e-01 6.59e-01
DNA DAMAGE BYPASS 46 7.61e-03 -2.28e-01 1.31e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 3.41e-02 -2.27e-01 3.23e-01
GAP JUNCTION ASSEMBLY 21 7.24e-02 2.26e-01 4.57e-01
TRANSLATION 286 5.57e-11 2.26e-01 2.17e-08
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.32e-01 -2.24e-01 5.59e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 3.11e-02 -2.24e-01 3.05e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 7.61e-02 -2.24e-01 4.70e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 3.48e-09 2.23e-01 5.08e-07
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.15e-02 2.23e-01 3.60e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 1.37e-01 -2.22e-01 5.59e-01
INTERFERON GAMMA SIGNALING 73 1.06e-03 -2.22e-01 2.96e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.89e-02 -2.22e-01 3.54e-01
SIGNALING BY HIPPO 20 8.87e-02 -2.20e-01 4.84e-01
UNWINDING OF DNA 12 1.88e-01 -2.19e-01 6.43e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 8.26e-03 2.18e-01 1.38e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 8.51e-04 2.17e-01 2.55e-02
ANCHORING FIBRIL FORMATION 13 1.77e-01 2.16e-01 6.28e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 2.15e-01 2.16e-01 6.63e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 5.72e-02 -2.16e-01 4.33e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 1.24e-01 -2.15e-01 5.55e-01
ADHERENS JUNCTIONS INTERACTIONS 30 4.14e-02 -2.15e-01 3.60e-01
PRE NOTCH PROCESSING IN GOLGI 17 1.25e-01 2.15e-01 5.55e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 1.51e-01 -2.14e-01 5.83e-01
MET ACTIVATES RAS SIGNALING 10 2.41e-01 -2.14e-01 6.77e-01
MITOCHONDRIAL TRANSLATION 93 3.67e-04 2.14e-01 1.26e-02
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 31 3.94e-02 2.14e-01 3.54e-01
MRNA SPLICING MINOR PATHWAY 52 8.71e-03 2.10e-01 1.41e-01
SHC MEDIATED CASCADE FGFR3 12 2.09e-01 2.10e-01 6.56e-01
INFLUENZA INFECTION 145 1.33e-05 2.10e-01 7.77e-04
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.47e-01 -2.10e-01 5.77e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 5.36e-05 2.09e-01 2.40e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 1.93e-01 2.09e-01 6.44e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 1.07e-01 -2.08e-01 5.32e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 2.54e-01 2.08e-01 6.88e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 11 2.33e-01 2.08e-01 6.72e-01
DARPP 32 EVENTS 23 8.76e-02 -2.06e-01 4.83e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 1.03e-01 -2.06e-01 5.22e-01
KERATAN SULFATE DEGRADATION 11 2.39e-01 2.05e-01 6.76e-01
RESPIRATORY ELECTRON TRANSPORT 102 3.78e-04 2.04e-01 1.26e-02
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 1.73e-01 2.03e-01 6.21e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 2.08e-01 2.02e-01 6.56e-01
GABA RECEPTOR ACTIVATION 52 1.21e-02 -2.01e-01 1.71e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 4.57e-02 -2.01e-01 3.83e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.11e-01 -2.01e-01 5.39e-01
CD28 DEPENDENT PI3K AKT SIGNALING 20 1.20e-01 -2.01e-01 5.55e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 2.11e-01 2.00e-01 6.58e-01
GLYCOGEN METABOLISM 25 8.59e-02 1.98e-01 4.83e-01
REGULATION OF IFNA SIGNALING 12 2.34e-01 -1.98e-01 6.72e-01
SIGNALING BY FGFR4 IN DISEASE 10 2.81e-01 -1.97e-01 7.01e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 1.38e-01 1.97e-01 5.59e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 1.89e-01 -1.96e-01 6.43e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 59 9.46e-03 -1.95e-01 1.49e-01
LYSINE CATABOLISM 11 2.62e-01 1.95e-01 6.93e-01
TRNA AMINOACYLATION 42 2.85e-02 1.95e-01 2.95e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 2.62e-01 -1.95e-01 6.93e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 13 2.23e-01 1.95e-01 6.67e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 1.42e-01 -1.95e-01 5.66e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 1.92e-01 -1.94e-01 6.44e-01
INTERFERON SIGNALING 160 2.25e-05 -1.94e-01 1.14e-03
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 1.93e-01 1.94e-01 6.44e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 4.43e-02 -1.94e-01 3.77e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 2.29e-01 1.93e-01 6.72e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 3.30e-02 1.92e-01 3.16e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 2.92e-01 1.92e-01 7.05e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 2.94e-01 -1.92e-01 7.06e-01
PYRUVATE METABOLISM 27 8.59e-02 -1.91e-01 4.83e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 1.45e-02 1.91e-01 1.90e-01
MITOTIC TELOPHASE CYTOKINESIS 13 2.35e-01 1.90e-01 6.72e-01
DERMATAN SULFATE BIOSYNTHESIS 11 2.80e-01 1.88e-01 7.01e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.81e-01 -1.88e-01 7.01e-01
NCAM1 INTERACTIONS 40 4.00e-02 1.88e-01 3.54e-01
SIGNALING BY ACTIVIN 12 2.62e-01 -1.87e-01 6.93e-01
SHC1 EVENTS IN EGFR SIGNALING 11 2.83e-01 -1.87e-01 7.01e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 2.72e-02 1.86e-01 2.91e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 1.22e-01 -1.86e-01 5.55e-01
LGI ADAM INTERACTIONS 14 2.28e-01 1.86e-01 6.71e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 3.10e-01 -1.85e-01 7.31e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 1.87e-01 1.85e-01 6.43e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 12 2.68e-01 -1.85e-01 6.99e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 6.86e-02 1.83e-01 4.48e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 310 3.13e-08 1.83e-01 2.93e-06
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.29e-01 -1.83e-01 5.59e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 1.79e-01 1.83e-01 6.34e-01
PI 3K CASCADE FGFR3 12 2.75e-01 1.82e-01 7.01e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 1.39e-01 1.82e-01 5.61e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 2.00e-02 -1.81e-01 2.36e-01
BILE ACID AND BILE SALT METABOLISM 25 1.20e-01 1.80e-01 5.55e-01
GLYCOGEN STORAGE DISEASES 12 2.81e-01 1.80e-01 7.01e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 2.45e-01 1.80e-01 6.85e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 2.82e-01 -1.79e-01 7.01e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.65e-01 1.79e-01 6.06e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.37e-01 1.79e-01 5.59e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 2.32e-01 1.78e-01 6.72e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 9.12e-02 -1.78e-01 4.87e-01
G PROTEIN BETA GAMMA SIGNALLING 30 9.13e-02 -1.78e-01 4.87e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 2.50e-01 -1.78e-01 6.87e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 8.73e-02 1.77e-01 4.83e-01
PROCESSING OF SMDT1 16 2.19e-01 -1.77e-01 6.67e-01
HDR THROUGH MMEJ ALT NHEJ 10 3.31e-01 1.77e-01 7.41e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 3.97e-02 -1.77e-01 3.54e-01
SIGNALING BY BMP 24 1.33e-01 -1.77e-01 5.59e-01
PLATELET CALCIUM HOMEOSTASIS 25 1.26e-01 -1.77e-01 5.56e-01
ACTIVATION OF BH3 ONLY PROTEINS 28 1.08e-01 -1.76e-01 5.33e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.37e-01 -1.75e-01 5.59e-01
SODIUM CALCIUM EXCHANGERS 10 3.38e-01 -1.75e-01 7.41e-01
COPII MEDIATED VESICLE TRANSPORT 66 1.40e-02 -1.75e-01 1.85e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.03e-01 -1.75e-01 5.22e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 2.76e-01 -1.75e-01 7.01e-01
CELLULAR HEXOSE TRANSPORT 11 3.17e-01 -1.74e-01 7.35e-01
RHOA GTPASE CYCLE 143 3.25e-04 1.74e-01 1.15e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 1.24e-01 1.74e-01 5.55e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 19 1.89e-01 1.74e-01 6.43e-01
FGFR2 ALTERNATIVE SPLICING 26 1.25e-01 1.74e-01 5.55e-01
SIGNALING BY ROBO RECEPTORS 205 2.24e-05 1.72e-01 1.14e-03
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.34e-01 -1.72e-01 6.72e-01
INTERLEUKIN 27 SIGNALING 10 3.50e-01 1.71e-01 7.50e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 60 2.27e-02 1.70e-01 2.57e-01
LONG TERM POTENTIATION 23 1.59e-01 -1.70e-01 5.98e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.89e-01 1.70e-01 6.43e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.01e-01 -1.69e-01 6.50e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 1.21e-01 -1.69e-01 5.55e-01
ANTIMICROBIAL PEPTIDES 13 2.91e-01 1.69e-01 7.04e-01
SELECTIVE AUTOPHAGY 72 1.32e-02 1.69e-01 1.79e-01
ENDOGENOUS STEROLS 21 1.81e-01 1.69e-01 6.36e-01
O LINKED GLYCOSYLATION OF MUCINS 41 6.31e-02 -1.68e-01 4.48e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 3.37e-01 -1.67e-01 7.41e-01
PHASE 0 RAPID DEPOLARISATION 31 1.07e-01 -1.67e-01 5.32e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 7.85e-02 -1.67e-01 4.77e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 4.52e-02 1.67e-01 3.82e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 23 1.67e-01 -1.67e-01 6.09e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 1.88e-02 -1.66e-01 2.27e-01
PURINE CATABOLISM 16 2.51e-01 1.66e-01 6.87e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.45e-01 1.65e-01 5.71e-01
MATURATION OF NUCLEOPROTEIN 10 3.68e-01 -1.64e-01 7.65e-01
EXTRACELLULAR MATRIX ORGANIZATION 242 1.17e-05 1.64e-01 7.16e-04
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 3.70e-01 -1.64e-01 7.65e-01
N GLYCAN ANTENNAE ELONGATION 15 2.79e-01 -1.61e-01 7.01e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 2.82e-01 -1.60e-01 7.01e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 3.18e-01 1.60e-01 7.35e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 2.05e-01 1.60e-01 6.53e-01
FORMATION OF APOPTOSOME 10 3.82e-01 -1.60e-01 7.74e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 3.62e-01 1.59e-01 7.61e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 8.69e-02 1.58e-01 4.83e-01
LAMININ INTERACTIONS 27 1.55e-01 1.58e-01 5.90e-01
G2 M DNA DAMAGE CHECKPOINT 65 2.83e-02 -1.57e-01 2.95e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 34 1.14e-01 1.57e-01 5.39e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 3.91e-01 -1.57e-01 7.76e-01
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.38e-01 1.56e-01 6.76e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 3.78e-02 1.56e-01 3.47e-01
METABOLISM OF RNA 643 1.86e-11 1.56e-01 1.08e-08
SIALIC ACID METABOLISM 32 1.27e-01 -1.56e-01 5.59e-01
THE NLRP3 INFLAMMASOME 15 3.00e-01 -1.55e-01 7.15e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 2.32e-01 -1.54e-01 6.72e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 13 3.37e-01 1.54e-01 7.41e-01
INTEGRIN CELL SURFACE INTERACTIONS 69 2.75e-02 1.54e-01 2.91e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 3.38e-01 -1.53e-01 7.41e-01
RHO GTPASES ACTIVATE PAKS 21 2.24e-01 1.53e-01 6.67e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.49e-01 -1.53e-01 6.87e-01
RHOC GTPASE CYCLE 73 2.45e-02 1.52e-01 2.70e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 3.62e-01 -1.52e-01 7.61e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 285 1.10e-05 -1.52e-01 7.13e-04
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.55e-02 -1.51e-01 2.76e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.67e-01 1.51e-01 6.99e-01
ACYL CHAIN REMODELLING OF PS 14 3.28e-01 -1.51e-01 7.41e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 3.88e-01 -1.50e-01 7.74e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.70e-01 1.50e-01 6.99e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 3.14e-01 -1.50e-01 7.34e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 2.99e-01 -1.50e-01 7.15e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 2.58e-01 -1.50e-01 6.90e-01
PENTOSE PHOSPHATE PATHWAY 13 3.50e-01 -1.50e-01 7.50e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 2.15e-01 -1.49e-01 6.63e-01
HEME SIGNALING 45 8.33e-02 -1.49e-01 4.83e-01
CDC42 GTPASE CYCLE 153 1.46e-03 1.49e-01 3.87e-02
RHOBTB2 GTPASE CYCLE 23 2.17e-01 1.49e-01 6.63e-01
FORMATION OF THE CORNIFIED ENVELOPE 29 1.66e-01 1.49e-01 6.06e-01
KERATINIZATION 29 1.66e-01 1.49e-01 6.06e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 2.89e-01 -1.48e-01 7.03e-01
PREGNENOLONE BIOSYNTHESIS 12 3.75e-01 1.48e-01 7.72e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.38e-01 -1.48e-01 7.41e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 2.53e-01 -1.48e-01 6.87e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 3.76e-01 1.48e-01 7.72e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 6.37e-02 1.47e-01 4.48e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.21e-01 -1.47e-01 7.94e-01
ERK MAPK TARGETS 22 2.34e-01 -1.46e-01 6.72e-01
HDACS DEACETYLATE HISTONES 45 8.97e-02 1.46e-01 4.85e-01
FRS MEDIATED FGFR3 SIGNALING 14 3.43e-01 1.46e-01 7.49e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 3.12e-01 1.46e-01 7.32e-01
VOLTAGE GATED POTASSIUM CHANNELS 40 1.11e-01 -1.46e-01 5.39e-01
RHOBTB3 ATPASE CYCLE 10 4.25e-01 -1.46e-01 7.94e-01
DISEASES OF IMMUNE SYSTEM 23 2.30e-01 1.45e-01 6.72e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 3.17e-01 -1.45e-01 7.35e-01
ERBB2 REGULATES CELL MOTILITY 14 3.50e-01 -1.44e-01 7.50e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 1.65e-01 1.44e-01 6.06e-01
INTERLEUKIN 10 SIGNALING 18 2.90e-01 -1.44e-01 7.04e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 1.48e-02 1.44e-01 1.92e-01
MITOPHAGY 29 1.83e-01 1.43e-01 6.40e-01
COSTIMULATION BY THE CD28 FAMILY 50 8.15e-02 -1.42e-01 4.80e-01
CA DEPENDENT EVENTS 36 1.40e-01 -1.42e-01 5.61e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 4.14e-01 1.42e-01 7.90e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 2.10e-01 -1.42e-01 6.58e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 2.72e-01 -1.42e-01 7.00e-01
CA2 PATHWAY 56 6.68e-02 -1.42e-01 4.48e-01
DEADENYLATION OF MRNA 25 2.22e-01 -1.41e-01 6.67e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 107 1.17e-02 1.41e-01 1.71e-01
DAP12 SIGNALING 24 2.32e-01 -1.41e-01 6.72e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 1.10e-01 -1.41e-01 5.39e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 15 3.45e-01 -1.41e-01 7.50e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 1.97e-01 1.41e-01 6.44e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 1.99e-01 1.40e-01 6.46e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 25 2.26e-01 -1.40e-01 6.70e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 4.04e-01 1.39e-01 7.82e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 49 9.21e-02 -1.39e-01 4.89e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 3.85e-01 -1.39e-01 7.74e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 5.20e-02 1.38e-01 4.13e-01
PROTEIN UBIQUITINATION 69 4.76e-02 -1.38e-01 3.87e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 6.78e-02 -1.37e-01 4.48e-01
MET RECEPTOR RECYCLING 10 4.52e-01 -1.37e-01 8.09e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 3.16e-01 1.36e-01 7.35e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 2.20e-01 -1.36e-01 6.67e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 3.47e-01 -1.36e-01 7.50e-01
HEDGEHOG ON STATE 82 3.48e-02 1.35e-01 3.27e-01
HEDGEHOG OFF STATE 106 1.67e-02 1.35e-01 2.12e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 6.77e-02 1.34e-01 4.48e-01
SIGNALING BY SCF KIT 41 1.38e-01 -1.34e-01 5.59e-01
ERKS ARE INACTIVATED 13 4.03e-01 -1.34e-01 7.82e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 4.42e-01 -1.34e-01 8.00e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 4.42e-01 -1.34e-01 8.00e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 4.44e-01 -1.33e-01 8.01e-01
REGULATION OF TNFR1 SIGNALING 34 1.80e-01 1.33e-01 6.35e-01
NGF STIMULATED TRANSCRIPTION 37 1.62e-01 -1.33e-01 6.05e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.71e-03 1.33e-01 6.33e-02
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.64e-01 1.32e-01 6.06e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.63e-01 1.32e-01 6.93e-01
SIGNALING BY WNT IN CANCER 31 2.03e-01 -1.32e-01 6.52e-01
HEME BIOSYNTHESIS 13 4.10e-01 -1.32e-01 7.87e-01
ACYL CHAIN REMODELLING OF PE 16 3.61e-01 -1.32e-01 7.61e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 1.22e-01 1.32e-01 5.55e-01
HEDGEHOG LIGAND BIOGENESIS 61 7.71e-02 1.31e-01 4.72e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 2.01e-01 1.31e-01 6.50e-01
INTERLEUKIN 6 FAMILY SIGNALING 19 3.26e-01 1.30e-01 7.41e-01
CELL JUNCTION ORGANIZATION 75 5.14e-02 -1.30e-01 4.11e-01
RHOB GTPASE CYCLE 67 6.63e-02 1.30e-01 4.48e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 4.18e-01 -1.30e-01 7.92e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 3.85e-01 1.30e-01 7.74e-01
HIV ELONGATION ARREST AND RECOVERY 32 2.06e-01 1.29e-01 6.53e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.30e-01 1.29e-01 5.59e-01
OLFACTORY SIGNALING PATHWAY 26 2.57e-01 1.28e-01 6.90e-01
RNA POLYMERASE I TRANSCRIPTION 67 7.07e-02 1.28e-01 4.49e-01
INTRA GOLGI TRAFFIC 43 1.48e-01 -1.28e-01 5.77e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 4.85e-01 1.28e-01 8.34e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 4.85e-01 -1.28e-01 8.34e-01
TRANSCRIPTIONAL REGULATION BY MECP2 60 8.82e-02 -1.27e-01 4.83e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.36e-01 1.27e-01 6.73e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 9.69e-02 -1.27e-01 5.03e-01
GLUCONEOGENESIS 27 2.53e-01 1.27e-01 6.87e-01
CRISTAE FORMATION 31 2.21e-01 1.27e-01 6.67e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 2.40e-01 -1.26e-01 6.76e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 4.75e-02 -1.26e-01 3.87e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 8.79e-02 -1.25e-01 4.83e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 6.83e-02 -1.25e-01 4.48e-01
METAL ION SLC TRANSPORTERS 24 2.89e-01 -1.25e-01 7.03e-01
RHOBTB GTPASE CYCLE 35 2.03e-01 1.24e-01 6.52e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 2.26e-01 1.24e-01 6.70e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.57e-01 -1.24e-01 6.90e-01
PHOSPHORYLATION OF THE APC C 17 3.78e-01 -1.24e-01 7.73e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 34 2.12e-01 1.24e-01 6.59e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 3.28e-01 -1.23e-01 7.41e-01
SIGNALING BY NTRK3 TRKC 17 3.79e-01 1.23e-01 7.74e-01
RESOLUTION OF ABASIC SITES AP SITES 37 1.95e-01 1.23e-01 6.44e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.58e-01 -1.23e-01 5.97e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 175 5.10e-03 -1.23e-01 1.04e-01
IRAK1 RECRUITS IKK COMPLEX 14 4.27e-01 1.23e-01 7.94e-01
SIGNALING BY HEDGEHOG 141 1.20e-02 1.23e-01 1.71e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 4.11e-01 1.23e-01 7.87e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 6.53e-02 -1.22e-01 4.48e-01
SIGNALING BY PDGF 56 1.13e-01 1.22e-01 5.39e-01
PLATELET HOMEOSTASIS 76 6.56e-02 -1.22e-01 4.48e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 89 4.72e-02 1.22e-01 3.87e-01
MET PROMOTES CELL MOTILITY 39 1.89e-01 1.22e-01 6.43e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 3.85e-01 1.22e-01 7.74e-01
CILIUM ASSEMBLY 189 4.13e-03 1.21e-01 8.92e-02
STRIATED MUSCLE CONTRACTION 27 2.78e-01 1.21e-01 7.01e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 3.08e-01 -1.20e-01 7.26e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 4.20e-01 1.20e-01 7.94e-01
PLASMA LIPOPROTEIN REMODELING 17 3.91e-01 -1.20e-01 7.76e-01
METHYLATION 11 4.91e-01 1.20e-01 8.42e-01
SIGNALING BY MET 75 7.31e-02 1.20e-01 4.59e-01
DAP12 INTERACTIONS 29 2.68e-01 -1.19e-01 6.99e-01
INTERLEUKIN 15 SIGNALING 12 4.76e-01 -1.19e-01 8.28e-01
SIGNALING BY NTRK2 TRKB 24 3.14e-01 -1.19e-01 7.34e-01
SIGNALING BY FGFR2 64 1.01e-01 1.19e-01 5.19e-01
DEGRADATION OF DVL 55 1.29e-01 1.18e-01 5.59e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 1.36e-01 1.18e-01 5.59e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.17e-01 -1.17e-01 6.63e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 3.91e-01 1.17e-01 7.76e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 3.33e-01 1.17e-01 7.41e-01
ACYL CHAIN REMODELLING OF PG 10 5.23e-01 -1.17e-01 8.60e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 43 1.87e-01 -1.16e-01 6.43e-01
UNFOLDED PROTEIN RESPONSE UPR 85 6.41e-02 1.16e-01 4.48e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 342 2.28e-04 -1.16e-01 8.57e-03
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 2.71e-01 1.16e-01 7.00e-01
CARNITINE METABOLISM 14 4.52e-01 -1.16e-01 8.09e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 10 5.26e-01 -1.16e-01 8.60e-01
SIGNALING BY CSF3 G CSF 29 2.82e-01 -1.15e-01 7.01e-01
KINESINS 47 1.72e-01 1.15e-01 6.21e-01
EPHB MEDIATED FORWARD SIGNALING 42 1.97e-01 -1.15e-01 6.44e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 3.22e-01 -1.14e-01 7.41e-01
EARLY PHASE OF HIV LIFE CYCLE 14 4.59e-01 -1.14e-01 8.11e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 6.91e-02 1.14e-01 4.48e-01
NRAGE SIGNALS DEATH THROUGH JNK 56 1.41e-01 1.14e-01 5.64e-01
RAF ACTIVATION 34 2.51e-01 -1.14e-01 6.87e-01
PEPTIDE HORMONE METABOLISM 59 1.34e-01 -1.13e-01 5.59e-01
CARGO CONCENTRATION IN THE ER 31 2.80e-01 -1.12e-01 7.01e-01
NEPHRIN FAMILY INTERACTIONS 22 3.64e-01 1.12e-01 7.62e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 1.45e-01 1.12e-01 5.71e-01
OTHER SEMAPHORIN INTERACTIONS 19 4.00e-01 -1.12e-01 7.82e-01
MICRORNA MIRNA BIOGENESIS 24 3.44e-01 1.12e-01 7.50e-01
FOXO MEDIATED TRANSCRIPTION 60 1.36e-01 -1.11e-01 5.59e-01
POTASSIUM CHANNELS 90 6.86e-02 -1.11e-01 4.48e-01
SLC TRANSPORTER DISORDERS 69 1.12e-01 -1.11e-01 5.39e-01
RHOU GTPASE CYCLE 33 2.72e-01 -1.11e-01 7.00e-01
RAC1 GTPASE CYCLE 177 1.12e-02 1.11e-01 1.70e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 4.74e-01 1.10e-01 8.26e-01
IRON UPTAKE AND TRANSPORT 51 1.73e-01 -1.10e-01 6.21e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 3.33e-01 -1.10e-01 7.41e-01
NEGATIVE REGULATION OF FLT3 14 4.78e-01 1.10e-01 8.29e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 4.78e-01 -1.09e-01 8.29e-01
HSF1 ACTIVATION 26 3.35e-01 1.09e-01 7.41e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 2.05e-01 -1.09e-01 6.53e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 3.46e-01 1.09e-01 7.50e-01
NEDDYLATION 217 5.80e-03 -1.09e-01 1.14e-01
KILLING MECHANISMS 10 5.52e-01 1.09e-01 8.72e-01
TNFR2 NON CANONICAL NF KB PATHWAY 80 9.36e-02 1.08e-01 4.94e-01
RND1 GTPASE CYCLE 38 2.48e-01 -1.08e-01 6.87e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 3.68e-01 -1.08e-01 7.65e-01
RESOLUTION OF D LOOP STRUCTURES 30 3.05e-01 -1.08e-01 7.25e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 3.80e-01 -1.08e-01 7.74e-01
GAP JUNCTION DEGRADATION 11 5.38e-01 1.07e-01 8.66e-01
INSULIN RECEPTOR RECYCLING 20 4.08e-01 -1.07e-01 7.86e-01
O LINKED GLYCOSYLATION 86 8.77e-02 -1.07e-01 4.83e-01
FLT3 SIGNALING 36 2.69e-01 -1.06e-01 6.99e-01
SIGNALING BY ERBB2 IN CANCER 25 3.59e-01 -1.06e-01 7.61e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 5.43e-01 1.06e-01 8.71e-01
EGFR DOWNREGULATION 28 3.34e-01 -1.06e-01 7.41e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 1.50e-01 -1.05e-01 5.79e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 2.45e-01 1.05e-01 6.85e-01
SIGNALING BY PDGFR IN DISEASE 20 4.18e-01 -1.05e-01 7.92e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 2.02e-01 -1.04e-01 6.50e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.25e-01 1.04e-01 7.41e-01
INTERLEUKIN 7 SIGNALING 20 4.23e-01 -1.03e-01 7.94e-01
COHESIN LOADING ONTO CHROMATIN 10 5.73e-01 1.03e-01 8.81e-01
G ALPHA I SIGNALLING EVENTS 193 1.39e-02 -1.03e-01 1.85e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 4.51e-01 -1.03e-01 8.09e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 5.74e-01 -1.03e-01 8.81e-01
MEIOTIC RECOMBINATION 38 2.75e-01 -1.02e-01 7.01e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 1.75e-01 1.02e-01 6.24e-01
STABILIZATION OF P53 54 1.95e-01 1.02e-01 6.44e-01
CYTOPROTECTION BY HMOX1 119 5.50e-02 1.02e-01 4.26e-01
METABOLISM OF FOLATE AND PTERINES 15 4.95e-01 1.02e-01 8.44e-01
BASE EXCISION REPAIR 56 1.89e-01 1.02e-01 6.43e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 1.37e-01 -1.01e-01 5.59e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 1.09e-01 1.01e-01 5.35e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 281 3.55e-03 1.01e-01 7.98e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 45 2.40e-01 1.01e-01 6.76e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 1.87e-01 1.01e-01 6.43e-01
HCMV EARLY EVENTS 79 1.21e-01 1.01e-01 5.55e-01
SENSORY PROCESSING OF SOUND 61 1.73e-01 1.01e-01 6.21e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 5.29e-01 1.01e-01 8.61e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.24e-01 1.00e-01 6.67e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 5.83e-01 1.00e-01 8.81e-01
INTEGRIN SIGNALING 24 3.96e-01 1.00e-01 7.79e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 12 5.49e-01 -1.00e-01 8.71e-01
PEROXISOMAL PROTEIN IMPORT 57 1.93e-01 -9.98e-02 6.44e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 9.57e-02 -9.85e-02 4.99e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.55e-01 -9.83e-02 8.73e-01
SIGNALLING TO ERKS 34 3.21e-01 -9.83e-02 7.41e-01
CHOLESTEROL BIOSYNTHESIS 24 4.05e-01 -9.83e-02 7.82e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 5.56e-01 9.81e-02 8.74e-01
RNA POLYMERASE III CHAIN ELONGATION 18 4.71e-01 9.81e-02 8.22e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 149 3.97e-02 9.77e-02 3.54e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 5.59e-01 9.73e-02 8.77e-01
THE PHOTOTRANSDUCTION CASCADE 21 4.41e-01 -9.71e-02 8.00e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 5.44e-01 -9.71e-02 8.71e-01
SULFUR AMINO ACID METABOLISM 22 4.32e-01 9.69e-02 7.94e-01
INTERLEUKIN 17 SIGNALING 66 1.75e-01 -9.67e-02 6.24e-01
RHOBTB1 GTPASE CYCLE 23 4.22e-01 9.67e-02 7.94e-01
PLATELET AGGREGATION PLUG FORMATION 33 3.38e-01 9.63e-02 7.41e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 1.90e-01 -9.63e-02 6.43e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 3.18e-01 -9.61e-02 7.35e-01
MITOTIC PROPHASE 92 1.13e-01 -9.57e-02 5.39e-01
GLYCOGEN SYNTHESIS 14 5.36e-01 9.56e-02 8.66e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 1.12e-01 -9.53e-02 5.39e-01
NETRIN 1 SIGNALING 49 2.49e-01 -9.51e-02 6.87e-01
POTENTIAL THERAPEUTICS FOR SARS 76 1.53e-01 9.50e-02 5.85e-01
ASSEMBLY OF THE HIV VIRION 16 5.13e-01 9.46e-02 8.55e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 3.87e-01 -9.45e-02 7.74e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.49e-01 9.45e-02 5.79e-01
MITOCHONDRIAL PROTEIN IMPORT 63 1.95e-01 9.44e-02 6.44e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 4.15e-01 9.42e-02 7.90e-01
AUTOPHAGY 138 5.70e-02 9.39e-02 4.33e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 4.08e-01 9.38e-02 7.86e-01
INWARDLY RECTIFYING K CHANNELS 31 3.70e-01 -9.30e-02 7.65e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.71e-01 -9.27e-02 6.21e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 4.13e-01 9.27e-02 7.90e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.52e-01 -9.26e-02 8.09e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 17 5.09e-01 9.26e-02 8.52e-01
NUCLEOTIDE SALVAGE 21 4.64e-01 -9.24e-02 8.14e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 3.38e-01 -9.24e-02 7.41e-01
PROTEIN FOLDING 89 1.33e-01 9.22e-02 5.59e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 4.34e-01 9.22e-02 7.94e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 5.81e-01 -9.21e-02 8.81e-01
BIOLOGICAL OXIDATIONS 123 7.89e-02 9.18e-02 4.77e-01
ZINC TRANSPORTERS 15 5.39e-01 -9.15e-02 8.67e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 3.95e-01 9.13e-02 7.79e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 597 1.52e-04 9.11e-02 6.33e-03
DEGRADATION OF AXIN 53 2.52e-01 9.10e-02 6.87e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 5.86e-01 9.09e-02 8.81e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 3.69e-01 9.04e-02 7.65e-01
MEIOTIC SYNAPSIS 39 3.30e-01 9.02e-02 7.41e-01
INTERLEUKIN 1 FAMILY SIGNALING 124 8.46e-02 8.98e-02 4.83e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 4.29e-01 -8.97e-02 7.94e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 5.23e-01 -8.95e-02 8.60e-01
SIGNALING BY NTRKS 131 7.73e-02 -8.95e-02 4.72e-01
ABC TRANSPORTER DISORDERS 71 1.93e-01 8.94e-02 6.44e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 4.59e-01 8.93e-02 8.11e-01
DUAL INCISION IN GG NER 40 3.29e-01 8.93e-02 7.41e-01
SEMAPHORIN INTERACTIONS 64 2.20e-01 8.87e-02 6.67e-01
AURKA ACTIVATION BY TPX2 71 1.97e-01 8.86e-02 6.44e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 3.28e-01 8.82e-02 7.41e-01
ANTIGEN PROCESSING CROSS PRESENTATION 93 1.42e-01 8.81e-02 5.66e-01
CTLA4 INHIBITORY SIGNALING 20 4.97e-01 -8.76e-02 8.45e-01
GP1B IX V ACTIVATION SIGNALLING 11 6.16e-01 8.74e-02 8.94e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 5.45e-01 -8.73e-02 8.71e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 3.91e-01 -8.63e-02 7.76e-01
NICOTINAMIDE SALVAGING 15 5.66e-01 8.57e-02 8.79e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1209 8.35e-07 -8.49e-02 6.50e-05
MITOTIC G2 G2 M PHASES 184 4.75e-02 8.48e-02 3.87e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 4.54e-01 -8.48e-02 8.09e-01
EPHRIN SIGNALING 19 5.23e-01 -8.46e-02 8.60e-01
POLYMERASE SWITCHING 14 5.84e-01 8.46e-02 8.81e-01
NERVOUS SYSTEM DEVELOPMENT 547 7.56e-04 8.45e-02 2.32e-02
MUCOPOLYSACCHARIDOSES 11 6.28e-01 -8.45e-02 9.00e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 3.33e-01 8.44e-02 7.41e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.03e-01 -8.44e-02 8.49e-01
SIGNALING BY INSULIN RECEPTOR 61 2.55e-01 -8.43e-02 6.88e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 2.49e-01 8.40e-02 6.87e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 3.77e-01 -8.39e-02 7.73e-01
CARDIAC CONDUCTION 108 1.33e-01 -8.37e-02 5.59e-01
INTRINSIC PATHWAY FOR APOPTOSIS 50 3.07e-01 -8.36e-02 7.26e-01
CELL CELL COMMUNICATION 107 1.36e-01 -8.35e-02 5.59e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 2.68e-01 8.34e-02 6.99e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 235 2.93e-02 -8.26e-02 2.95e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 5.81e-01 8.23e-02 8.81e-01
CRMPS IN SEMA3A SIGNALING 16 5.69e-01 -8.23e-02 8.81e-01
CITRIC ACID CYCLE TCA CYCLE 22 5.04e-01 8.23e-02 8.49e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 3.58e-01 -8.20e-02 7.61e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.38e-01 -8.19e-02 9.02e-01
ASPARAGINE N LINKED GLYCOSYLATION 283 1.83e-02 -8.17e-02 2.27e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 51 3.15e-01 -8.14e-02 7.34e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 5.50e-01 -8.14e-02 8.72e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 5.86e-01 -8.13e-02 8.81e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 5.75e-01 -8.10e-02 8.81e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 5.31e-01 8.10e-02 8.61e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 4.67e-01 -8.08e-02 8.19e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 5.03e-01 8.08e-02 8.49e-01
TELOMERE EXTENSION BY TELOMERASE 23 5.05e-01 8.04e-02 8.49e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 2.88e-01 8.01e-02 7.03e-01
VISUAL PHOTOTRANSDUCTION 61 2.80e-01 -7.99e-02 7.01e-01
G1 S DNA DAMAGE CHECKPOINTS 65 2.66e-01 7.97e-02 6.99e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 108 1.53e-01 7.96e-02 5.85e-01
METABOLISM OF PORPHYRINS 19 5.49e-01 -7.95e-02 8.71e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 2.89e-01 7.91e-02 7.03e-01
DAG AND IP3 SIGNALING 40 3.87e-01 -7.90e-02 7.74e-01
OPIOID SIGNALLING 86 2.08e-01 -7.85e-02 6.56e-01
SHC MEDIATED CASCADE FGFR4 10 6.68e-01 7.83e-02 9.11e-01
METABOLISM OF NUCLEOTIDES 91 1.98e-01 -7.82e-02 6.44e-01
TNF SIGNALING 43 3.76e-01 7.81e-02 7.72e-01
RECYCLING PATHWAY OF L1 40 3.94e-01 7.79e-02 7.79e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 2.49e-01 7.75e-02 6.87e-01
SYNTHESIS OF PC 25 5.05e-01 7.71e-02 8.49e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 94 1.97e-01 -7.70e-02 6.44e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.95e-01 7.70e-02 7.08e-01
REGULATION OF FZD BY UBIQUITINATION 19 5.61e-01 -7.70e-02 8.78e-01
RNA POLYMERASE III TRANSCRIPTION 41 3.94e-01 7.69e-02 7.79e-01
SIGNALING BY FGFR 74 2.53e-01 7.69e-02 6.87e-01
NEURONAL SYSTEM 363 1.26e-02 -7.64e-02 1.76e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 6.21e-01 -7.63e-02 8.94e-01
HDMS DEMETHYLATE HISTONES 27 4.94e-01 -7.60e-02 8.44e-01
PCP CE PATHWAY 90 2.13e-01 7.60e-02 6.59e-01
ADAPTIVE IMMUNE SYSTEM 599 1.61e-03 -7.58e-02 4.17e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 4.32e-01 -7.58e-02 7.94e-01
DSCAM INTERACTIONS 11 6.64e-01 -7.57e-02 9.11e-01
DISEASES OF METABOLISM 199 6.59e-02 7.57e-02 4.48e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.59e-01 7.57e-02 8.11e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 169 9.02e-02 -7.56e-02 4.85e-01
RHOV GTPASE CYCLE 32 4.59e-01 -7.56e-02 8.11e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 5.70e-01 -7.54e-02 8.81e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 4.85e-01 -7.50e-02 8.34e-01
CD209 DC SIGN SIGNALING 18 5.83e-01 -7.48e-02 8.81e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 1.37e-01 -7.48e-02 5.59e-01
IRS MEDIATED SIGNALLING 37 4.32e-01 -7.47e-02 7.94e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 2.24e-01 7.47e-02 6.67e-01
CELLULAR RESPONSE TO HYPOXIA 71 2.80e-01 7.43e-02 7.01e-01
PTEN REGULATION 134 1.39e-01 7.42e-02 5.61e-01
BASIGIN INTERACTIONS 22 5.47e-01 -7.41e-02 8.71e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 6.19e-01 -7.41e-02 8.94e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 5.86e-01 7.41e-02 8.81e-01
INTRAFLAGELLAR TRANSPORT 49 3.70e-01 7.40e-02 7.65e-01
SIGNALING BY NOTCH2 33 4.63e-01 -7.39e-02 8.14e-01
REGULATION OF PTEN GENE TRANSCRIPTION 59 3.28e-01 7.36e-02 7.41e-01
ENOS ACTIVATION 11 6.73e-01 -7.36e-02 9.11e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 5.90e-01 -7.34e-02 8.83e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 5.61e-01 7.33e-02 8.78e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 6.36e-01 7.32e-02 9.02e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 2.40e-01 -7.29e-02 6.76e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 5.45e-01 7.28e-02 8.71e-01
ION HOMEOSTASIS 48 3.84e-01 -7.26e-02 7.74e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 6.77e-01 7.26e-02 9.13e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 5.31e-01 7.23e-02 8.61e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 3.58e-01 7.23e-02 7.61e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 5.01e-01 -7.22e-02 8.49e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 4.60e-01 7.22e-02 8.11e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 6.53e-01 7.19e-02 9.11e-01
G1 S SPECIFIC TRANSCRIPTION 26 5.26e-01 -7.19e-02 8.60e-01
REGULATED PROTEOLYSIS OF P75NTR 12 6.67e-01 7.18e-02 9.11e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 5.12e-01 7.16e-02 8.55e-01
METABOLISM OF POLYAMINES 57 3.50e-01 7.16e-02 7.50e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 4.45e-01 7.16e-02 8.03e-01
RHOG GTPASE CYCLE 73 2.91e-01 7.15e-02 7.04e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 6.46e-01 -7.08e-02 9.06e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 21 5.75e-01 -7.07e-02 8.81e-01
CHONDROITIN SULFATE BIOSYNTHESIS 19 5.95e-01 -7.05e-02 8.85e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 6.37e-01 7.04e-02 9.02e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 3.63e-01 -7.04e-02 7.61e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 5.06e-01 -7.02e-02 8.50e-01
ESR MEDIATED SIGNALING 163 1.25e-01 -6.98e-02 5.55e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 4.96e-01 -6.96e-02 8.44e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 2.99e-01 6.93e-02 7.15e-01
RHO GTPASES ACTIVATE KTN1 11 6.91e-01 6.93e-02 9.17e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.33e-01 -6.92e-02 7.94e-01
PI METABOLISM 79 2.89e-01 -6.90e-02 7.03e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 5.86e-01 -6.87e-02 8.81e-01
NUCLEAR ENVELOPE NE REASSEMBLY 63 3.46e-01 6.87e-02 7.50e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 5.30e-01 -6.85e-02 8.61e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 90 2.64e-01 -6.81e-02 6.96e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 4.01e-01 -6.80e-02 7.82e-01
TP53 REGULATES METABOLIC GENES 84 2.85e-01 -6.76e-02 7.01e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 2.38e-01 6.73e-02 6.76e-01
MITOTIC PROMETAPHASE 175 1.25e-01 6.73e-02 5.56e-01
G PROTEIN MEDIATED EVENTS 52 4.02e-01 -6.72e-02 7.82e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 4.11e-01 6.72e-02 7.87e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 6.43e-01 6.69e-02 9.02e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 6.33e-01 -6.68e-02 9.02e-01
INTERLEUKIN 35 SIGNALLING 10 7.15e-01 6.67e-02 9.24e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 6.06e-01 6.66e-02 8.89e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 7.03e-01 6.63e-02 9.23e-01
SHC MEDIATED CASCADE FGFR1 15 6.57e-01 6.63e-02 9.11e-01
S PHASE 153 1.60e-01 -6.59e-02 6.00e-01
UCH PROTEINASES 88 2.86e-01 6.58e-02 7.03e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 6.81e-01 6.58e-02 9.13e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 6.94e-01 6.56e-02 9.18e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 5.14e-01 6.56e-02 8.55e-01
NICOTINATE METABOLISM 24 5.78e-01 6.56e-02 8.81e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 2.71e-01 6.53e-02 7.00e-01
GLYCOSAMINOGLYCAN METABOLISM 114 2.31e-01 -6.49e-02 6.72e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 7.11e-01 -6.46e-02 9.24e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 5.69e-01 -6.45e-02 8.81e-01
DEVELOPMENTAL BIOLOGY 811 2.12e-03 6.39e-02 5.10e-02
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 4.69e-01 -6.38e-02 8.21e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 4.51e-01 6.36e-02 8.09e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 3.60e-01 6.33e-02 7.61e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 176 1.49e-01 6.31e-02 5.79e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 3.81e-01 6.29e-02 7.74e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 5.21e-01 -6.28e-02 8.60e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 3.80e-01 6.25e-02 7.74e-01
SIGNALING BY RETINOIC ACID 33 5.38e-01 -6.20e-02 8.66e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 5.09e-01 6.20e-02 8.52e-01
OTHER INTERLEUKIN SIGNALING 20 6.32e-01 6.19e-02 9.02e-01
HCMV INFECTION 102 2.81e-01 6.18e-02 7.01e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 5.54e-01 6.14e-02 8.73e-01
GLUCAGON TYPE LIGAND RECEPTORS 23 6.11e-01 -6.14e-02 8.94e-01
SARS COV 1 INFECTION 48 4.64e-01 6.12e-02 8.14e-01
RHOQ GTPASE CYCLE 58 4.22e-01 6.10e-02 7.94e-01
SIGNALLING TO RAS 20 6.37e-01 6.10e-02 9.02e-01
NONHOMOLOGOUS END JOINING NHEJ 43 4.90e-01 -6.09e-02 8.42e-01
INTERLEUKIN 1 SIGNALING 95 3.06e-01 6.09e-02 7.25e-01
G2 M CHECKPOINTS 133 2.28e-01 -6.05e-02 6.71e-01
SIGNALING BY FGFR2 IIIA TM 19 6.49e-01 6.04e-02 9.08e-01
GLUTATHIONE CONJUGATION 29 5.75e-01 6.02e-02 8.81e-01
LAGGING STRAND SYNTHESIS 20 6.42e-01 6.01e-02 9.02e-01
HOMOLOGY DIRECTED REPAIR 107 2.83e-01 -6.01e-02 7.01e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 6.98e-01 5.99e-02 9.22e-01
PI3K AKT SIGNALING IN CANCER 89 3.30e-01 -5.97e-02 7.41e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 6.79e-01 -5.97e-02 9.13e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 5.66e-01 -5.96e-02 8.79e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 4.55e-01 -5.94e-02 8.09e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.22e-01 -5.92e-02 9.26e-01
CHROMATIN MODIFYING ENZYMES 217 1.34e-01 5.91e-02 5.59e-01
TRANS GOLGI NETWORK VESICLE BUDDING 70 3.97e-01 -5.85e-02 7.81e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 6.68e-01 5.85e-02 9.11e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 7.37e-01 5.85e-02 9.35e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 6.20e-01 5.84e-02 8.94e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.43e-01 5.84e-02 9.02e-01
MITOCHONDRIAL BIOGENESIS 92 3.34e-01 5.84e-02 7.41e-01
SIGNALING BY ERYTHROPOIETIN 24 6.21e-01 5.83e-02 8.94e-01
INOSITOL PHOSPHATE METABOLISM 47 4.91e-01 5.81e-02 8.42e-01
SIGNAL AMPLIFICATION 30 5.82e-01 -5.81e-02 8.81e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 62 4.30e-01 -5.80e-02 7.94e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 3.60e-01 5.78e-02 7.61e-01
PARASITE INFECTION 55 4.60e-01 -5.76e-02 8.11e-01
TRIGLYCERIDE CATABOLISM 14 7.11e-01 -5.72e-02 9.24e-01
SEPARATION OF SISTER CHROMATIDS 165 2.06e-01 5.72e-02 6.53e-01
RESOLUTION OF SISTER CHROMATID COHESION 100 3.25e-01 5.70e-02 7.41e-01
GPCR LIGAND BINDING 261 1.17e-01 -5.65e-02 5.49e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 2.55e-01 -5.58e-02 6.88e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 5.75e-01 -5.56e-02 8.81e-01
RAS PROCESSING 24 6.39e-01 5.54e-02 9.02e-01
RHO GTPASE CYCLE 427 5.05e-02 5.53e-02 4.06e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 3.87e-01 5.53e-02 7.74e-01
SIGNALING BY FGFR3 34 5.78e-01 5.51e-02 8.81e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 1.90e-02 5.51e-02 2.27e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 4.32e-01 -5.48e-02 7.94e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 6.73e-01 5.45e-02 9.11e-01
ARACHIDONIC ACID METABOLISM 40 5.51e-01 5.45e-02 8.72e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 180 2.10e-01 -5.42e-02 6.58e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 6.14e-01 5.42e-02 8.94e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 4.37e-01 5.42e-02 7.97e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 7.18e-01 5.38e-02 9.24e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 6.55e-01 5.38e-02 9.11e-01
HS GAG BIOSYNTHESIS 29 6.18e-01 -5.36e-02 8.94e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 6.72e-01 -5.35e-02 9.11e-01
GENERATION OF SECOND MESSENGER MOLECULES 20 6.79e-01 5.34e-02 9.13e-01
DNA REPAIR 291 1.18e-01 -5.34e-02 5.53e-01
NEGATIVE REGULATION OF MAPK PATHWAY 43 5.46e-01 -5.33e-02 8.71e-01
REGULATION OF RAS BY GAPS 66 4.54e-01 5.33e-02 8.09e-01
GABA B RECEPTOR ACTIVATION 39 5.65e-01 -5.33e-02 8.79e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 6.81e-01 -5.32e-02 9.13e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 7.22e-01 -5.31e-02 9.26e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 6.82e-01 -5.30e-02 9.13e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 5.77e-01 -5.30e-02 8.81e-01
NUCLEAR ENVELOPE BREAKDOWN 47 5.30e-01 -5.29e-02 8.61e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 6.54e-01 -5.29e-02 9.11e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 6.17e-01 -5.27e-02 8.94e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 7.63e-01 5.26e-02 9.45e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 6.13e-01 -5.25e-02 8.94e-01
SYNTHESIS OF PA 29 6.26e-01 5.24e-02 8.98e-01
PLASMA LIPOPROTEIN CLEARANCE 27 6.41e-01 5.19e-02 9.02e-01
GPVI MEDIATED ACTIVATION CASCADE 31 6.18e-01 5.18e-02 8.94e-01
HIV TRANSCRIPTION ELONGATION 42 5.62e-01 5.17e-02 8.78e-01
SUMOYLATION 162 2.58e-01 -5.16e-02 6.90e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 117 3.36e-01 5.15e-02 7.41e-01
PYROPTOSIS 20 6.91e-01 -5.14e-02 9.17e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 4.23e-01 5.12e-02 7.94e-01
FCERI MEDIATED NF KB ACTIVATION 76 4.41e-01 5.11e-02 8.00e-01
MYOGENESIS 25 6.59e-01 -5.10e-02 9.11e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 6.59e-01 5.09e-02 9.11e-01
FATTY ACYL COA BIOSYNTHESIS 32 6.19e-01 5.08e-02 8.94e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 82 4.28e-01 -5.07e-02 7.94e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 7.61e-01 5.07e-02 9.45e-01
NOD1 2 SIGNALING PATHWAY 35 6.04e-01 5.06e-02 8.89e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 92 4.05e-01 5.03e-02 7.82e-01
NUCLEOBASE BIOSYNTHESIS 15 7.36e-01 -5.02e-02 9.35e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 3.99e-01 5.01e-02 7.82e-01
DISEASES OF PROGRAMMED CELL DEATH 54 5.25e-01 5.01e-02 8.60e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 7.06e-01 -5.00e-02 9.23e-01
MAPK6 MAPK4 SIGNALING 83 4.32e-01 4.99e-02 7.94e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 4.10e-01 -4.98e-02 7.87e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 5.77e-01 -4.97e-02 8.81e-01
PLATELET SENSITIZATION BY LDL 15 7.39e-01 4.96e-02 9.36e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 5.84e-01 4.95e-02 8.81e-01
MITOTIC METAPHASE AND ANAPHASE 205 2.27e-01 4.90e-02 6.71e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.36e-01 -4.89e-02 7.97e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 4.24e-01 -4.85e-02 7.94e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 7.14e-01 4.85e-02 9.24e-01
NUCLEAR IMPORT OF REV PROTEIN 32 6.35e-01 -4.85e-02 9.02e-01
RNA POLYMERASE II TRANSCRIPTION 1084 7.52e-03 -4.85e-02 1.31e-01
REGULATION OF BACH1 ACTIVITY 11 7.82e-01 -4.82e-02 9.50e-01
PHASE 2 PLATEAU PHASE 13 7.64e-01 -4.81e-02 9.45e-01
SIGNALING BY GPCR 478 7.40e-02 -4.79e-02 4.62e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 7.74e-01 4.78e-02 9.48e-01
MTORC1 MEDIATED SIGNALLING 24 6.87e-01 4.76e-02 9.17e-01
DNA REPLICATION 121 3.67e-01 -4.75e-02 7.65e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 7.07e-01 -4.74e-02 9.23e-01
HCMV LATE EVENTS 64 5.13e-01 -4.73e-02 8.55e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 7.96e-01 4.73e-02 9.53e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 3.99e-01 -4.70e-02 7.82e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 6.17e-01 4.69e-02 8.94e-01
TRANSPORT OF SMALL MOLECULES 568 5.75e-02 -4.68e-02 4.33e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 7.46e-01 4.68e-02 9.40e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.11e-01 -4.67e-02 9.24e-01
METALLOPROTEASE DUBS 25 6.86e-01 -4.67e-02 9.17e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 5.35e-01 4.67e-02 8.66e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.90e-01 -4.64e-02 9.53e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 7.56e-01 -4.64e-02 9.42e-01
PRC2 METHYLATES HISTONES AND DNA 29 6.66e-01 4.63e-02 9.11e-01
RAB REGULATION OF TRAFFICKING 118 3.86e-01 -4.62e-02 7.74e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 7.02e-01 4.61e-02 9.23e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 6.01e-01 4.61e-02 8.89e-01
PI 3K CASCADE FGFR2 16 7.50e-01 4.60e-02 9.40e-01
DEATH RECEPTOR SIGNALLING 134 3.59e-01 4.60e-02 7.61e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 141 3.48e-01 -4.58e-02 7.50e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 7.93e-01 -4.58e-02 9.53e-01
RHO GTPASE EFFECTORS 247 2.16e-01 4.58e-02 6.63e-01
BUDDING AND MATURATION OF HIV VIRION 27 6.81e-01 4.57e-02 9.13e-01
APOPTOTIC EXECUTION PHASE 45 5.96e-01 -4.57e-02 8.86e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 7.17e-01 -4.57e-02 9.24e-01
VXPX CARGO TARGETING TO CILIUM 19 7.31e-01 4.55e-02 9.32e-01
SARS COV 2 INFECTION 65 5.26e-01 -4.55e-02 8.60e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 7.39e-01 4.53e-02 9.36e-01
PI 3K CASCADE FGFR4 10 8.04e-01 4.53e-02 9.54e-01
TRANSCRIPTION OF THE HIV GENOME 67 5.24e-01 4.50e-02 8.60e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 6.92e-01 4.49e-02 9.18e-01
DNA STRAND ELONGATION 32 6.61e-01 -4.47e-02 9.11e-01
LYSOSOME VESICLE BIOGENESIS 33 6.58e-01 4.45e-02 9.11e-01
SIGNALING BY LEPTIN 10 8.08e-01 4.43e-02 9.56e-01
PI 3K CASCADE FGFR1 15 7.67e-01 4.42e-02 9.45e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 540 8.01e-02 -4.42e-02 4.79e-01
NUCLEAR SIGNALING BY ERBB4 31 6.71e-01 4.41e-02 9.11e-01
SIGNALING BY NUCLEAR RECEPTORS 220 2.61e-01 -4.41e-02 6.93e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 6.63e-01 4.38e-02 9.11e-01
METABOLISM OF COFACTORS 18 7.48e-01 4.37e-02 9.40e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 6.90e-01 4.35e-02 9.17e-01
FANCONI ANEMIA PATHWAY 36 6.53e-01 4.34e-02 9.11e-01
STIMULI SENSING CHANNELS 74 5.20e-01 -4.32e-02 8.60e-01
G ALPHA Z SIGNALLING EVENTS 45 6.16e-01 -4.32e-02 8.94e-01
TRIGLYCERIDE METABOLISM 22 7.27e-01 -4.30e-02 9.29e-01
SIGNALING BY PTK6 50 5.99e-01 4.30e-02 8.89e-01
L1CAM INTERACTIONS 109 4.40e-01 4.28e-02 8.00e-01
PEROXISOMAL LIPID METABOLISM 26 7.06e-01 -4.28e-02 9.23e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 5.90e-01 4.24e-02 8.83e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 51 6.01e-01 -4.24e-02 8.89e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 7.49e-01 4.23e-02 9.40e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 7.04e-01 -4.23e-02 9.23e-01
INFECTIOUS DISEASE 727 5.38e-02 4.22e-02 4.24e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 8.00e-01 -4.22e-02 9.54e-01
MEMBRANE TRAFFICKING 579 8.74e-02 -4.17e-02 4.83e-01
LDL CLEARANCE 16 7.73e-01 4.17e-02 9.48e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 7.41e-01 -4.17e-02 9.36e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 108 4.54e-01 4.17e-02 8.09e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 7.95e-01 -4.16e-02 9.53e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 5.94e-01 -4.15e-02 8.85e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 6.71e-01 4.15e-02 9.11e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 3.42e-01 4.14e-02 7.48e-01
TCR SIGNALING 102 4.70e-01 4.14e-02 8.21e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 7.05e-01 4.14e-02 9.23e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 6.72e-01 -4.13e-02 9.11e-01
RHOH GTPASE CYCLE 37 6.69e-01 -4.06e-02 9.11e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 7.10e-01 -4.06e-02 9.24e-01
G ALPHA S SIGNALLING EVENTS 103 4.79e-01 -4.04e-02 8.29e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 7.80e-01 4.03e-02 9.50e-01
RAC2 GTPASE CYCLE 86 5.21e-01 4.01e-02 8.60e-01
CELL CYCLE CHECKPOINTS 241 2.85e-01 -4.01e-02 7.01e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 6.31e-01 -4.01e-02 9.02e-01
INFLAMMASOMES 19 7.63e-01 -3.99e-02 9.45e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 6.88e-01 -3.98e-02 9.17e-01
SIGNALING BY ERBB4 57 6.04e-01 -3.97e-02 8.89e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 6.38e-01 3.96e-02 9.02e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 226 3.05e-01 3.96e-02 7.25e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 8.05e-01 -3.96e-02 9.54e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 5.27e-01 -3.95e-02 8.61e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 8.13e-01 3.93e-02 9.58e-01
SIGNALING BY NOTCH4 83 5.37e-01 3.92e-02 8.66e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 5.14e-01 -3.91e-02 8.55e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.32e-01 -3.91e-02 7.94e-01
EPH EPHRIN SIGNALING 90 5.22e-01 -3.91e-02 8.60e-01
SENSORY PERCEPTION 146 4.16e-01 3.90e-02 7.91e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 8.32e-01 -3.87e-02 9.68e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 183 3.69e-01 -3.85e-02 7.65e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 7.86e-01 3.80e-02 9.52e-01
RHOF GTPASE CYCLE 40 6.84e-01 -3.73e-02 9.15e-01
REGULATION OF SIGNALING BY CBL 22 7.63e-01 3.72e-02 9.45e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 5.66e-01 3.69e-02 8.79e-01
RHO GTPASES ACTIVATE FORMINS 118 4.92e-01 3.66e-02 8.42e-01
HYALURONAN METABOLISM 15 8.08e-01 -3.63e-02 9.56e-01
PD 1 SIGNALING 10 8.43e-01 3.62e-02 9.70e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 8.21e-01 -3.62e-02 9.63e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 17 7.97e-01 -3.61e-02 9.53e-01
DNA REPLICATION PRE INITIATION 79 5.82e-01 -3.58e-02 8.81e-01
SIGNALING BY NOTCH1 75 5.93e-01 3.57e-02 8.85e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 7.33e-01 -3.55e-02 9.32e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 7.18e-01 -3.53e-02 9.24e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 7.56e-01 -3.52e-02 9.42e-01
REPRODUCTION 75 6.01e-01 3.49e-02 8.89e-01
ION CHANNEL TRANSPORT 138 4.80e-01 -3.48e-02 8.30e-01
MAPK FAMILY SIGNALING CASCADES 288 3.12e-01 3.47e-02 7.32e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 7.35e-01 3.45e-02 9.35e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 7.80e-01 -3.45e-02 9.50e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 76 6.05e-01 -3.44e-02 8.89e-01
REGULATION OF BETA CELL DEVELOPMENT 24 7.71e-01 -3.43e-02 9.48e-01
NEUREXINS AND NEUROLIGINS 54 6.64e-01 3.42e-02 9.11e-01
HATS ACETYLATE HISTONES 91 5.73e-01 -3.42e-02 8.81e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 6.70e-01 -3.41e-02 9.11e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 6.94e-01 -3.39e-02 9.18e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 8.33e-01 3.37e-02 9.68e-01
FCERI MEDIATED MAPK ACTIVATION 28 7.59e-01 -3.35e-02 9.45e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 10 8.55e-01 3.34e-02 9.71e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 7.82e-01 3.33e-02 9.50e-01
FRS MEDIATED FGFR2 SIGNALING 18 8.07e-01 3.32e-02 9.56e-01
SIGNALING BY NOTCH 188 4.34e-01 3.31e-02 7.94e-01
EFFECTS OF PIP2 HYDROLYSIS 27 7.66e-01 3.31e-02 9.45e-01
NUCLEOTIDE EXCISION REPAIR 109 5.55e-01 -3.28e-02 8.73e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 6.80e-01 3.27e-02 9.13e-01
EXTENSION OF TELOMERES 50 6.90e-01 3.26e-02 9.17e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 6.56e-01 -3.25e-02 9.11e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 42 7.17e-01 -3.23e-02 9.24e-01
G PROTEIN ACTIVATION 22 7.96e-01 -3.19e-02 9.53e-01
TBC RABGAPS 43 7.18e-01 -3.19e-02 9.24e-01
SPRY REGULATION OF FGF SIGNALING 16 8.29e-01 -3.11e-02 9.68e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 6.26e-01 -3.10e-02 8.98e-01
FRS MEDIATED FGFR1 SIGNALING 17 8.26e-01 3.09e-02 9.67e-01
SIGNALING BY INTERLEUKINS 348 3.27e-01 3.07e-02 7.41e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 7.68e-01 -3.07e-02 9.45e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.49e-01 3.05e-02 9.71e-01
PROLACTIN RECEPTOR SIGNALING 11 8.61e-01 -3.05e-02 9.71e-01
DNA METHYLATION 20 8.14e-01 3.05e-02 9.58e-01
GLYCOSPHINGOLIPID METABOLISM 38 7.47e-01 -3.03e-02 9.40e-01
NUCLEOBASE CATABOLISM 31 7.72e-01 -3.01e-02 9.48e-01
SYNTHESIS OF PE 12 8.57e-01 -3.00e-02 9.71e-01
INTERACTION BETWEEN L1 AND ANKYRINS 29 7.80e-01 2.99e-02 9.50e-01
TOLL LIKE RECEPTOR CASCADES 137 5.47e-01 -2.98e-02 8.71e-01
CIRCADIAN CLOCK 68 6.76e-01 -2.94e-02 9.13e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 8.12e-01 -2.92e-02 9.58e-01
VESICLE MEDIATED TRANSPORT 608 2.24e-01 -2.90e-02 6.67e-01
INTERLEUKIN 12 FAMILY SIGNALING 44 7.40e-01 2.89e-02 9.36e-01
CLEC7A DECTIN 1 SIGNALING 94 6.30e-01 2.87e-02 9.01e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 15 8.47e-01 -2.87e-02 9.71e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 110 6.05e-01 -2.86e-02 8.89e-01
METABOLISM OF VITAMINS AND COFACTORS 150 5.51e-01 2.83e-02 8.72e-01
SIGNALING BY FGFR IN DISEASE 55 7.17e-01 2.82e-02 9.24e-01
DEFECTS IN COBALAMIN B12 METABOLISM 12 8.66e-01 2.82e-02 9.71e-01
LEISHMANIA INFECTION 193 5.01e-01 -2.81e-02 8.49e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 7.98e-01 2.80e-02 9.53e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 8.57e-01 2.79e-02 9.71e-01
M PHASE 337 3.83e-01 2.77e-02 7.74e-01
OXIDATIVE STRESS INDUCED SENESCENCE 78 6.73e-01 2.77e-02 9.11e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 8.64e-01 2.74e-02 9.71e-01
SIGNALING BY FGFR4 31 7.93e-01 2.73e-02 9.53e-01
TRP CHANNELS 19 8.37e-01 -2.72e-02 9.69e-01
TRNA PROCESSING 105 6.30e-01 2.72e-02 9.01e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.82e-01 2.71e-02 9.76e-01
RA BIOSYNTHESIS PATHWAY 13 8.67e-01 -2.68e-02 9.71e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 7.49e-01 2.67e-02 9.40e-01
SARS COV INFECTIONS 139 5.90e-01 2.65e-02 8.83e-01
MAP2K AND MAPK ACTIVATION 36 7.85e-01 2.63e-02 9.52e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 8.03e-01 2.63e-02 9.54e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 8.28e-01 2.62e-02 9.68e-01
FRS MEDIATED FGFR4 SIGNALING 12 8.75e-01 2.62e-02 9.76e-01
DISEASES OF GLYCOSYLATION 125 6.14e-01 2.62e-02 8.94e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 8.35e-01 -2.57e-02 9.68e-01
REGULATION OF TP53 ACTIVITY 148 5.92e-01 2.56e-02 8.84e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.89e-01 2.55e-02 9.76e-01
CELLULAR RESPONSE TO HEAT STRESS 95 6.70e-01 2.53e-02 9.11e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 8.32e-01 -2.50e-02 9.68e-01
NEUTROPHIL DEGRANULATION 383 4.03e-01 2.50e-02 7.82e-01
MTOR SIGNALLING 40 7.86e-01 -2.48e-02 9.52e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 7.32e-01 -2.48e-02 9.32e-01
HIV TRANSCRIPTION INITIATION 45 7.74e-01 -2.48e-02 9.48e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 8.37e-01 -2.47e-02 9.69e-01
HEMOSTASIS 472 3.60e-01 2.47e-02 7.61e-01
RAC3 GTPASE CYCLE 88 6.95e-01 -2.42e-02 9.18e-01
CHROMOSOME MAINTENANCE 103 6.71e-01 2.42e-02 9.11e-01
FATTY ACID METABOLISM 146 6.14e-01 2.42e-02 8.94e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 8.80e-01 -2.41e-02 9.76e-01
IRAK4 DEFICIENCY TLR2 4 12 8.86e-01 2.38e-02 9.76e-01
AQUAPORIN MEDIATED TRANSPORT 40 7.96e-01 -2.37e-02 9.53e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 8.51e-01 -2.36e-02 9.71e-01
ACYL CHAIN REMODELLING OF PC 17 8.67e-01 2.35e-02 9.71e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 7.54e-01 -2.32e-02 9.42e-01
RECEPTOR MEDIATED MITOPHAGY 11 8.94e-01 2.31e-02 9.76e-01
HIV LIFE CYCLE 143 6.38e-01 2.28e-02 9.02e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 8.83e-01 2.28e-02 9.76e-01
ION TRANSPORT BY P TYPE ATPASES 47 7.89e-01 -2.26e-02 9.53e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 8.88e-01 -2.25e-02 9.76e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 8.41e-01 2.24e-02 9.69e-01
TRANSLESION SYNTHESIS BY POLH 19 8.66e-01 2.24e-02 9.71e-01
NEUROTRANSMITTER RELEASE CYCLE 48 7.90e-01 2.23e-02 9.53e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 7.61e-01 -2.22e-02 9.45e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 100 7.02e-01 2.22e-02 9.23e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 184 6.05e-01 -2.22e-02 8.89e-01
INTERLEUKIN 6 SIGNALING 10 9.04e-01 -2.21e-02 9.76e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 8.21e-01 2.21e-02 9.63e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 7.30e-01 2.18e-02 9.32e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 8.35e-01 -2.16e-02 9.68e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 8.78e-01 2.15e-02 9.76e-01
AMYLOID FIBER FORMATION 57 7.81e-01 -2.13e-02 9.50e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 81 7.44e-01 2.10e-02 9.38e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 7.52e-01 -2.10e-02 9.42e-01
GAB1 SIGNALOSOME 14 8.92e-01 2.09e-02 9.76e-01
ONCOGENE INDUCED SENESCENCE 32 8.38e-01 -2.08e-02 9.69e-01
C TYPE LECTIN RECEPTORS CLRS 112 7.04e-01 2.08e-02 9.23e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 7.81e-01 -2.08e-02 9.50e-01
SURFACTANT METABOLISM 16 8.87e-01 2.05e-02 9.76e-01
G0 AND EARLY G1 24 8.62e-01 -2.05e-02 9.71e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 8.57e-01 2.04e-02 9.71e-01
PEPTIDE LIGAND BINDING RECEPTORS 103 7.25e-01 -2.01e-02 9.27e-01
PECAM1 INTERACTIONS 12 9.08e-01 1.93e-02 9.76e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 9.08e-01 -1.93e-02 9.76e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 8.46e-01 -1.92e-02 9.71e-01
MEIOSIS 63 7.93e-01 -1.92e-02 9.53e-01
INTERLEUKIN 12 SIGNALING 37 8.41e-01 -1.91e-02 9.69e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 14 9.02e-01 1.90e-02 9.76e-01
METABOLISM OF LIPIDS 611 4.28e-01 -1.89e-02 7.94e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 7.20e-01 -1.87e-02 9.26e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.82e-01 1.87e-02 9.76e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 9.07e-01 -1.87e-02 9.76e-01
MITOTIC SPINDLE CHECKPOINT 96 7.53e-01 -1.86e-02 9.42e-01
REGULATED NECROSIS 45 8.31e-01 -1.84e-02 9.68e-01
PKMTS METHYLATE HISTONE LYSINES 48 8.27e-01 1.83e-02 9.68e-01
PERK REGULATES GENE EXPRESSION 28 8.67e-01 -1.82e-02 9.71e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 8.88e-01 -1.82e-02 9.76e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 9.00e-01 1.81e-02 9.76e-01
VIRAL MESSENGER RNA SYNTHESIS 42 8.40e-01 -1.80e-02 9.69e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 9.11e-01 -1.80e-02 9.78e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 8.58e-01 1.79e-02 9.71e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 8.88e-01 1.77e-02 9.76e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 8.54e-01 -1.73e-02 9.71e-01
INTEGRATION OF ENERGY METABOLISM 98 7.68e-01 1.73e-02 9.45e-01
TRANSLESION SYNTHESIS BY POLK 17 9.02e-01 -1.73e-02 9.76e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 8.18e-01 -1.70e-02 9.62e-01
MISMATCH REPAIR 14 9.13e-01 1.69e-02 9.79e-01
METABOLISM OF CARBOHYDRATES 258 6.41e-01 -1.69e-02 9.02e-01
HS GAG DEGRADATION 20 8.96e-01 -1.68e-02 9.76e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 85 7.97e-01 -1.62e-02 9.53e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 8.85e-01 -1.61e-02 9.76e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 8.81e-01 -1.61e-02 9.76e-01
METABOLISM OF FAT SOLUBLE VITAMINS 33 8.77e-01 1.56e-02 9.76e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 21 9.04e-01 1.52e-02 9.76e-01
ESTROGEN DEPENDENT GENE EXPRESSION 100 7.98e-01 -1.48e-02 9.53e-01
INNATE IMMUNE SYSTEM 772 4.96e-01 1.45e-02 8.44e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 8.94e-01 1.43e-02 9.76e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 8.35e-01 1.40e-02 9.68e-01
KERATAN SULFATE BIOSYNTHESIS 24 9.08e-01 -1.37e-02 9.76e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 8.89e-01 -1.37e-02 9.76e-01
DEUBIQUITINATION 241 7.17e-01 -1.36e-02 9.24e-01
SIGNAL TRANSDUCTION BY L1 21 9.15e-01 1.35e-02 9.80e-01
GOLGI TO ER RETROGRADE TRANSPORT 118 8.04e-01 -1.32e-02 9.54e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 9.02e-01 -1.32e-02 9.76e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 8.53e-01 1.32e-02 9.71e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 9.40e-01 1.30e-02 9.85e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 114 8.10e-01 -1.30e-02 9.57e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 8.63e-01 1.30e-02 9.71e-01
SIGNALING BY FGFR2 IN DISEASE 36 8.93e-01 1.30e-02 9.76e-01
SPHINGOLIPID METABOLISM 79 8.46e-01 -1.27e-02 9.71e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 9.35e-01 -1.25e-02 9.84e-01
TRAFFICKING OF AMPA RECEPTORS 31 9.04e-01 1.25e-02 9.76e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.43e-01 1.25e-02 9.85e-01
TIE2 SIGNALING 17 9.29e-01 1.25e-02 9.83e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.24e-01 -1.23e-02 9.83e-01
SIGNALING BY VEGF 102 8.30e-01 1.23e-02 9.68e-01
REGULATION OF INSULIN SECRETION 71 8.61e-01 -1.20e-02 9.71e-01
GENE SILENCING BY RNA 84 8.50e-01 -1.20e-02 9.71e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 9.23e-01 1.19e-02 9.83e-01
TRNA PROCESSING IN THE NUCLEUS 56 8.80e-01 -1.17e-02 9.76e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 8.60e-01 -1.16e-02 9.71e-01
SIGNALING BY ERBB2 48 8.91e-01 -1.15e-02 9.76e-01
RND3 GTPASE CYCLE 38 9.03e-01 -1.14e-02 9.76e-01
MUSCLE CONTRACTION 163 8.01e-01 1.14e-02 9.54e-01
GLUCOSE METABOLISM 80 8.65e-01 1.10e-02 9.71e-01
RHOJ GTPASE CYCLE 54 8.89e-01 1.10e-02 9.76e-01
PROTEIN LOCALIZATION 156 8.14e-01 -1.09e-02 9.58e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 8.49e-01 -1.09e-02 9.71e-01
SIGNALING BY EGFR 47 8.98e-01 1.08e-02 9.76e-01
DUAL INCISION IN TC NER 64 8.83e-01 -1.07e-02 9.76e-01
SNRNP ASSEMBLY 51 8.97e-01 -1.05e-02 9.76e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 9.29e-01 -1.04e-02 9.83e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 464 7.04e-01 1.03e-02 9.23e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 9.38e-01 1.02e-02 9.85e-01
RHOD GTPASE CYCLE 50 9.05e-01 9.78e-03 9.76e-01
MRNA CAPPING 29 9.28e-01 9.63e-03 9.83e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 8.85e-01 9.56e-03 9.76e-01
CALNEXIN CALRETICULIN CYCLE 26 9.33e-01 9.55e-03 9.84e-01
CELL CYCLE MITOTIC 471 7.24e-01 9.52e-03 9.27e-01
P38MAPK EVENTS 13 9.53e-01 9.44e-03 9.85e-01
TRANSCRIPTIONAL REGULATION BY TP53 338 7.66e-01 -9.42e-03 9.45e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 140 8.50e-01 -9.25e-03 9.71e-01
ERYTHROPOIETIN ACTIVATES RAS 13 9.55e-01 8.98e-03 9.85e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 52 9.11e-01 8.96e-03 9.78e-01
ONCOGENIC MAPK SIGNALING 77 8.93e-01 -8.90e-03 9.76e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.29e-01 -8.81e-03 9.83e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 366 7.78e-01 -8.61e-03 9.50e-01
SIGNALING BY NOTCH3 48 9.19e-01 8.52e-03 9.82e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 9.44e-01 8.11e-03 9.85e-01
ASPARTATE AND ASPARAGINE METABOLISM 10 9.65e-01 8.10e-03 9.87e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 9.55e-01 -7.66e-03 9.85e-01
SIGNALING BY FGFR1 IN DISEASE 32 9.41e-01 7.51e-03 9.85e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 9.36e-01 7.20e-03 9.84e-01
HIV INFECTION 221 8.60e-01 6.90e-03 9.71e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 9.33e-01 6.78e-03 9.84e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 9.70e-01 6.65e-03 9.88e-01
PRE NOTCH EXPRESSION AND PROCESSING 63 9.27e-01 6.64e-03 9.83e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.56e-01 -6.61e-03 9.85e-01
DNA DAMAGE RECOGNITION IN GG NER 38 9.44e-01 6.59e-03 9.85e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 9.55e-01 6.45e-03 9.85e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 9.67e-01 6.21e-03 9.88e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 9.20e-01 -6.11e-03 9.82e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 9.61e-01 -5.91e-03 9.85e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 35 9.52e-01 5.83e-03 9.85e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 9.26e-01 -5.73e-03 9.83e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 9.45e-01 5.70e-03 9.85e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 9.70e-01 -5.68e-03 9.88e-01
MHC CLASS II ANTIGEN PRESENTATION 103 9.22e-01 5.60e-03 9.83e-01
FLT3 SIGNALING IN DISEASE 27 9.60e-01 -5.51e-03 9.85e-01
RND2 GTPASE CYCLE 38 9.54e-01 5.44e-03 9.85e-01
SIGNALING BY FGFR1 43 9.51e-01 -5.43e-03 9.85e-01
RET SIGNALING 37 9.56e-01 -5.26e-03 9.85e-01
CELLULAR SENESCENCE 140 9.16e-01 5.15e-03 9.80e-01
PHASE II CONJUGATION OF COMPOUNDS 60 9.46e-01 5.08e-03 9.85e-01
HOST INTERACTIONS OF HIV FACTORS 125 9.23e-01 -4.98e-03 9.83e-01
UB SPECIFIC PROCESSING PROTEASES 167 9.13e-01 -4.89e-03 9.79e-01
RHO GTPASES ACTIVATE PKNS 47 9.54e-01 -4.88e-03 9.85e-01
ORC1 REMOVAL FROM CHROMATIN 67 9.45e-01 -4.83e-03 9.85e-01
KERATAN SULFATE KERATIN METABOLISM 30 9.64e-01 4.77e-03 9.87e-01
RUNX3 REGULATES NOTCH SIGNALING 13 9.77e-01 4.64e-03 9.91e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 9.60e-01 -4.50e-03 9.85e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 9.68e-01 -4.50e-03 9.88e-01
METABOLISM OF STEROIDS 112 9.35e-01 4.48e-03 9.84e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 282 9.01e-01 4.30e-03 9.76e-01
AMINO ACIDS REGULATE MTORC1 51 9.58e-01 -4.24e-03 9.85e-01
TELOMERE MAINTENANCE 79 9.48e-01 4.24e-03 9.85e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 9.49e-01 4.21e-03 9.85e-01
SIGNALING BY NODAL 15 9.79e-01 4.00e-03 9.91e-01
APOPTOSIS 162 9.34e-01 3.78e-03 9.84e-01
RORA ACTIVATES GENE EXPRESSION 18 9.78e-01 -3.75e-03 9.91e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 9.68e-01 3.65e-03 9.88e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 9.77e-01 -3.65e-03 9.91e-01
PHOSPHOLIPID METABOLISM 186 9.32e-01 -3.64e-03 9.84e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 138 9.44e-01 3.50e-03 9.85e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 9.85e-01 -3.32e-03 9.94e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 17 9.82e-01 3.22e-03 9.92e-01
METABOLISM OF STEROID HORMONES 20 9.80e-01 3.22e-03 9.91e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 9.76e-01 -2.71e-03 9.91e-01
SIGNALING BY EGFR IN CANCER 22 9.86e-01 2.22e-03 9.94e-01
PROTEIN METHYLATION 17 9.88e-01 -2.19e-03 9.94e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 62 9.79e-01 1.96e-03 9.91e-01
SIGNALING BY WNT 266 9.60e-01 -1.78e-03 9.85e-01
GLYCOLYSIS 66 9.80e-01 -1.75e-03 9.91e-01
PURINE SALVAGE 12 9.92e-01 -1.66e-03 9.96e-01
CELL CYCLE 589 9.48e-01 1.58e-03 9.85e-01
PROGRAMMED CELL DEATH 184 9.71e-01 -1.55e-03 9.89e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 9.88e-01 1.48e-03 9.94e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 9.91e-01 -1.43e-03 9.96e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 9.88e-01 -1.37e-03 9.94e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 9.94e-01 1.23e-03 9.96e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 27 9.93e-01 9.98e-04 9.96e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 9.96e-01 5.00e-04 9.97e-01
G ALPHA Q SIGNALLING EVENTS 156 9.96e-01 -2.57e-04 9.97e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.00e+00 1.55e-05 1.00e+00


Detailed Gene set reports



MET ACTIVATES RAP1 AND RAC1
set MET ACTIVATES RAP1 AND RAC1
setSize 11
pANOVA 0.00104
s.dist -0.571
p.adjustANOVA 0.0295


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rap1b -8382
Met -7793
Hgf -7787
Rac1 -7095
Dock7 -6823
Crkl -5517
Rap1a -5256
Crk -5199
Gab1 -4854
Grb2 -3236
Rapgef1 4682

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All member genes
GeneID Gene Rank
Rap1b -8382
Met -7793
Hgf -7787
Rac1 -7095
Dock7 -6823
Crkl -5517
Rap1a -5256
Crk -5199
Gab1 -4854
Grb2 -3236
Rapgef1 4682


SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
set SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
setSize 11
pANOVA 0.00214
s.dist -0.535
p.adjustANOVA 0.051


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7643
Pik3c3 -6281
Mtmr9 -5966
Mtmr7 -5770
Mtmr4 -5615
Fig4 -4292
Pik3r4 -3304
Mtm1 393
Vac14 639

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7643
Pik3c3 -6281
Mtmr9 -5966
Mtmr7 -5770
Mtmr4 -5615
Fig4 -4292
Pik3r4 -3304
Mtm1 393
Vac14 639


ACTIVATION OF RAC1
set ACTIVATION OF RAC1
setSize 13
pANOVA 0.00176
s.dist -0.501
p.adjustANOVA 0.0446


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slit2 -8763
Pak1 -7267
Robo1 -7153
Rac1 -7095
Sos2 -6284
Sos1 -5958
Pak5 -5257
Pak3 -3693
Pak6 -2728
Pak2 -2271
Pak4 -1911
Nck2 -1100
Nck1 -530

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slit2 -8763
Pak1 -7267
Robo1 -7153
Rac1 -7095
Sos2 -6284
Sos1 -5958
Pak5 -5257
Pak3 -3693
Pak6 -2728
Pak2 -2271
Pak4 -1911
Nck2 -1100
Nck1 -530


INITIAL TRIGGERING OF COMPLEMENT
set INITIAL TRIGGERING OF COMPLEMENT
setSize 10
pANOVA 0.01
s.dist 0.47
p.adjustANOVA 0.154


Top enriched genes
Top 20 genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6968
Masp2 5997
C4b 4906
C1qc 4384
C1qa 3002
Masp1 2827
Gzmm -547
Cfb -7717

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All member genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6968
Masp2 5997
C4b 4906
C1qc 4384
C1qa 3002
Masp1 2827
Gzmm -547
Cfb -7717


EUKARYOTIC TRANSLATION ELONGATION
set EUKARYOTIC TRANSLATION ELONGATION
setSize 87
pANOVA 1.84e-12
s.dist 0.437
p.adjustANOVA 2.14e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps28 7598
Rps8 7451
Rpl26 7361
Rpl28 7126
Eef1d 6826
Rpl38 6636
Rplp2 6621
Rps29 6611
Eef1a2 6280
Rpl35 6267
Eef2 6160
Rpl23a 6157
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps28 7598
Rps8 7451
Rpl26 7361
Rpl28 7126
Eef1d 6826
Rpl38 6636
Rplp2 6621
Rps29 6611
Eef1a2 6280
Rpl35 6267
Eef2 6160
Rpl23a 6157
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533
Rpl37 5532
Rps19 5402
Rpl6 5383
Rps18 5261
Rpl8 5183
Rps27l 4782
Rpl35a 4750
Eef1g 4671
Rplp1 4498
Rpl7a 4490
Rpl24 4486
Rps25 4351
Rps3a1 4213
Rpl14 4029
Rpl32 4023
Rpl13 3984
Rps17 3941
Rps11 3935
Rpl18a 3930
Uba52 3877
Rpl12 3791
Rpl10 3756
Rps6 3748
Fau 3715
Rpl30 3436
Rps16 3426
Rpl31 3268
Rps14 3150
Rps24 3078
Rps15 3028
Rpl21 3025
Rps10 2980
Rpl27a 2893
Eef1b2 2809
Rpl36al 2752
Rps7 2732
Rpl19 2669
Rpl3 2655
Rpsa 2615
Rpl36 2444
Rpl11 2321
Rps5 2250
Rpl18 1870
Rps27 1671
Rpl9 1495
Rpl5 1299
Rps12 1219
Rpl36a 928
Rpl10a 896
Rpl4 874
Rps23 873
Rpl22 733
Rpl27 529
Rpl13a 406
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Rpl7 -1359
Rps15a -1948
Rpl39 -2432
Rpl17 -2701
Eef1a1 -2853
Rpl15 -3334
Rpl22l1 -3376


CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
set CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
setSize 11
pANOVA 0.0122
s.dist -0.437
p.adjustANOVA 0.171


Top enriched genes
Top 20 genes
GeneID Gene Rank
Prkacb -8544
Prkar2b -8346
Prkar1a -7991
Creb1 -7648
Prkx -7159
Calm1 -6804
Adcy1 -4574
Prkar1b -546
Adcy8 662
Prkaca 1783
Prkar2a 4343

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prkacb -8544
Prkar2b -8346
Prkar1a -7991
Creb1 -7648
Prkx -7159
Calm1 -6804
Adcy1 -4574
Prkar1b -546
Adcy8 662
Prkaca 1783
Prkar2a 4343


NF KB IS ACTIVATED AND SIGNALS SURVIVAL
set NF KB IS ACTIVATED AND SIGNALS SURVIVAL
setSize 13
pANOVA 0.00679
s.dist 0.434
p.adjustANOVA 0.124


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ikbkb 6595
Nfkb1 6577
Irak1 6338
Rps27a 5855
Ngfr 5543
Uba52 3877
Ubc 3090
Ubb 2616
Ngf 2469
Nfkbia 2119
Sqstm1 728
Rela 29
Traf6 -3829

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ikbkb 6595
Nfkb1 6577
Irak1 6338
Rps27a 5855
Ngfr 5543
Uba52 3877
Ubc 3090
Ubb 2616
Ngf 2469
Nfkbia 2119
Sqstm1 728
Rela 29
Traf6 -3829


ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
set ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
setSize 16
pANOVA 0.00277
s.dist 0.432
p.adjustANOVA 0.0634


Top enriched genes
Top 20 genes
GeneID Gene Rank
Irf3 7215
Ticam2 6837
Cd14 6547
Rps27a 5855
Ikbke 4961
Ptpn11 4359
Ticam1 4300
Tlr4 3894
Uba52 3877
Traf3 3514
Ubc 3090
Tank 2756
Ubb 2616
Tbk1 644
Sarm1 -166
Irf7 -8811

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf3 7215
Ticam2 6837
Cd14 6547
Rps27a 5855
Ikbke 4961
Ptpn11 4359
Ticam1 4300
Tlr4 3894
Uba52 3877
Traf3 3514
Ubc 3090
Tank 2756
Ubb 2616
Tbk1 644
Sarm1 -166
Irf7 -8811


SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE
set SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE
setSize 20
pANOVA 0.000908
s.dist 0.429
p.adjustANOVA 0.0265


Top enriched genes
Top 20 genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7494
Limk2 7422
Plxnb1 6904
Limk1 6630
Myh9 6344
Rhoc 5773
Rnd1 5409
Myl6 4896
Myl12b 4332
Myh10 3505
Arhgef11 2058
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2060
Rhoa -3488
Rhob -5013

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7494
Limk2 7422
Plxnb1 6904
Limk1 6630
Myh9 6344
Rhoc 5773
Rnd1 5409
Myl6 4896
Myl12b 4332
Myh10 3505
Arhgef11 2058
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2060
Rhoa -3488
Rhob -5013


CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
set CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
setSize 13
pANOVA 0.00921
s.dist 0.417
p.adjustANOVA 0.147


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ercc2 7654
Ciao2b 7480
Pold1 6728
Ndor1 5199
Ciapin1 5075
Ciao3 5064
Rtel1 4821
Brip1 4240
Nubp1 3461
Abcb7 -1266
Mms19 -1590
Nubp2 -3105
Ciao1 -3549

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ercc2 7654
Ciao2b 7480
Pold1 6728
Ndor1 5199
Ciapin1 5075
Ciao3 5064
Rtel1 4821
Brip1 4240
Nubp1 3461
Abcb7 -1266
Mms19 -1590
Nubp2 -3105
Ciao1 -3549


SCAVENGING BY CLASS A RECEPTORS
set SCAVENGING BY CLASS A RECEPTORS
setSize 14
pANOVA 0.00754
s.dist 0.412
p.adjustANOVA 0.131


Top enriched genes
Top 20 genes
GeneID Gene Rank
Calr 7889
Col1a2 7493
Colec12 7330
Apoe 6026
Col3a1 5987
Col4a2 5672
Masp1 2827
Col1a1 2600
Hsp90b1 2548
Ftl1 1746
Apoa1 -74
Fth1 -278
Col4a1 -844
Scara5 -6166

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calr 7889
Col1a2 7493
Colec12 7330
Apoe 6026
Col3a1 5987
Col4a2 5672
Masp1 2827
Col1a1 2600
Hsp90b1 2548
Ftl1 1746
Apoa1 -74
Fth1 -278
Col4a1 -844
Scara5 -6166


SEROTONIN RECEPTORS
set SEROTONIN RECEPTORS
setSize 10
pANOVA 0.0291
s.dist -0.398
p.adjustANOVA 0.295


Top enriched genes
Top 20 genes
GeneID Gene Rank
Htr4 -8729
Htr5a -7228
Htr2a -7181
Htr2c -6736
Htr1d -5088
Htr6 -2891
Htr1f -2721
Htr1a 57
Htr1b 1193
Htr7 1776

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Htr4 -8729
Htr5a -7228
Htr2a -7181
Htr2c -6736
Htr1d -5088
Htr6 -2891
Htr1f -2721
Htr1a 57
Htr1b 1193
Htr7 1776


COLLAGEN CHAIN TRIMERIZATION
set COLLAGEN CHAIN TRIMERIZATION
setSize 40
pANOVA 1.46e-05
s.dist 0.396
p.adjustANOVA 0.000809


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7493
Col16a1 7369
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Col6a2 6294
Col3a1 5987
Col6a1 5962
Col4a2 5672
Col28a1 4764
Col6a3 4622
Col15a1 4607
Col9a3 3790

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7493
Col16a1 7369
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Col6a2 6294
Col3a1 5987
Col6a1 5962
Col4a2 5672
Col28a1 4764
Col6a3 4622
Col15a1 4607
Col9a3 3790
Col18a1 3051
Col24a1 2998
Col1a1 2600
Col4a5 2487
Col17a1 2391
Col6a5 2357
Col20a1 1864
Col4a3 1851
Col11a1 1223
Col14a1 -449
Col19a1 -590
Col8a1 -758
Col4a1 -844
Col5a1 -939
Col23a1 -3679
Col9a1 -4503
Col6a6 -5130
Col25a1 -5181
Col22a1 -5348
Col8a2 -7556


SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
set SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
setSize 16
pANOVA 0.00613
s.dist -0.396
p.adjustANOVA 0.114


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7643
Pik3c3 -6281
Mtmr12 -5788
Mtmr4 -5615
Fig4 -4292
Inpp5f -4105
Inpp4a -3944
Pi4k2b -3901
Pik3r4 -3304
Mtmr10 -1072
Mtm1 393
Inpp4b 582
Vac14 639
Pi4k2a 670

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7643
Pik3c3 -6281
Mtmr12 -5788
Mtmr4 -5615
Fig4 -4292
Inpp5f -4105
Inpp4a -3944
Pi4k2b -3901
Pik3r4 -3304
Mtmr10 -1072
Mtm1 393
Inpp4b 582
Vac14 639
Pi4k2a 670


REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA
set REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA
setSize 13
pANOVA 0.0188
s.dist 0.376
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
Irf3 7215
Rps27a 5855
Sting1 5288
Ddx41 4212
Uba52 3877
Dtx4 3120
Ubc 3090
Ubb 2616
Trim56 1621
Tbk1 644
Trim32 -53
Trex1 -238
Trim21 -1496

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf3 7215
Rps27a 5855
Sting1 5288
Ddx41 4212
Uba52 3877
Dtx4 3120
Ubc 3090
Ubb 2616
Trim56 1621
Tbk1 644
Trim32 -53
Trex1 -238
Trim21 -1496


RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
set RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize 94
pANOVA 3.7e-10
s.dist 0.374
p.adjustANOVA 7.86e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ddit3 7640
Rps28 7598
Rps8 7451
Rpl26 7361
Rpl28 7126
Rpl38 6636
Rplp2 6621
Rps29 6611
Rpl35 6267
Gcn1 6175
Rpl23a 6157
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ddit3 7640
Rps28 7598
Rps8 7451
Rpl26 7361
Rpl28 7126
Rpl38 6636
Rplp2 6621
Rps29 6611
Rpl35 6267
Gcn1 6175
Rpl23a 6157
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533
Rpl37 5532
Rps19 5402
Rpl6 5383
Rps18 5261
Rpl8 5183
Rps27l 4782
Rpl35a 4750
Rplp1 4498
Rpl7a 4490
Rpl24 4486
Rps25 4351
Rps3a1 4213
Rpl14 4029
Rpl32 4023
Rpl13 3984
Rps17 3941
Rps11 3935
Rpl18a 3930
Uba52 3877
Atf4 3828
Rpl12 3791
Rpl10 3756
Rps6 3748
Fau 3715
Rpl30 3436
Rps16 3426
Rpl31 3268
Rps14 3150
Rps24 3078
Rps15 3028
Rpl21 3025
Rps10 2980
Rpl27a 2893
Rpl36al 2752
Rps7 2732
Rpl19 2669
Rpl3 2655
Atf3 2634
Rpsa 2615
Rpl36 2444
Rpl11 2321
Rps5 2250
Rpl18 1870
Rps27 1671
Rpl9 1495
Rpl5 1299
Rps12 1219
Rpl36a 928
Rpl10a 896
Impact 880
Rpl4 874
Rps23 873
Eif2ak4 841
Rpl22 733
Rpl27 529
Rpl13a 406
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Eif2s1 -1087
Rpl7 -1359
Eif2s2 -1396
Cebpg -1747
Eif2s3x -1930
Rps15a -1948
Rpl39 -2432
Rpl17 -2701
Rpl15 -3334
Rpl22l1 -3376
Cebpb -4233
Asns -6277
Atf2 -8357


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
set ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize 12
pANOVA 0.0277
s.dist 0.367
p.adjustANOVA 0.291


Top enriched genes
Top 20 genes
GeneID Gene Rank
Elovl1 7986
Acaa1a 6083
Acot8 5804
Abcd1 5705
Fads1 5190
Hsd17b4 4960
Fads2 4817
Scp2 1615
Elovl5 404
Elovl2 -903
Acsl1 -4241
Acox1 -5346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elovl1 7986
Acaa1a 6083
Acot8 5804
Abcd1 5705
Fads1 5190
Hsd17b4 4960
Fads2 4817
Scp2 1615
Elovl5 404
Elovl2 -903
Acsl1 -4241
Acox1 -5346


COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
set COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
setSize 63
pANOVA 9.62e-07
s.dist 0.357
p.adjustANOVA 7.01e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col13a1 7899
Bmp1 7814
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
P4ha2 7609
Col1a2 7493
Col16a1 7369
Plod3 7309
P3h3 7258
Colgalt1 7128
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Serpinh1 6690
Col6a2 6294
Col3a1 5987

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col13a1 7899
Bmp1 7814
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
P4ha2 7609
Col1a2 7493
Col16a1 7369
Plod3 7309
P3h3 7258
Colgalt1 7128
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Serpinh1 6690
Col6a2 6294
Col3a1 5987
Col6a1 5962
P4ha3 5891
Col4a2 5672
P3h1 5216
P4ha1 4859
Col28a1 4764
Pcolce 4734
Col6a3 4622
Col15a1 4607
Plod1 4560
Col9a3 3790
Ppib 3227
Col18a1 3051
Col24a1 2998
Col1a1 2600
Col4a5 2487
Col17a1 2391
Col6a5 2357
Col20a1 1864
Col4a3 1851
Pcolce2 1605
Col11a1 1223
Tll2 1167
Plod2 558
Adamts14 546
Col14a1 -449
Col19a1 -590
Col8a1 -758
Col4a1 -844
Col5a1 -939
P4hb -1564
Crtap -3467
Col23a1 -3679
Tll1 -3737
Colgalt2 -3768
Col9a1 -4503
Col6a6 -5130
Col25a1 -5181
Col22a1 -5348
Adamts2 -5587
P3h2 -5830
Adamts3 -6207
Col8a2 -7556


NONSENSE MEDIATED DECAY NMD
set NONSENSE MEDIATED DECAY NMD
setSize 109
pANOVA 4.04e-10
s.dist 0.347
p.adjustANOVA 7.86e-08


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps28 7598
Upf3a 7471
Rps8 7451
Rpl26 7361
Rpl28 7126
Rpl38 6636
Rplp2 6621
Rps29 6611
Rpl35 6267
Rpl23a 6157
Rps13 5970
Upf2 5923
Rps27a 5855
Upf3b 5812
Eif4g1 5757
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps28 7598
Upf3a 7471
Rps8 7451
Rpl26 7361
Rpl28 7126
Rpl38 6636
Rplp2 6621
Rps29 6611
Rpl35 6267
Rpl23a 6157
Rps13 5970
Upf2 5923
Rps27a 5855
Upf3b 5812
Eif4g1 5757
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533
Rpl37 5532
Rps19 5402
Rpl6 5383
Rbm8a 5295
Rps18 5261
Rpl8 5183
Casc3 5114
Rps27l 4782
Eif4a3 4763
Rpl35a 4750
Upf1 4647
Rplp1 4498
Rpl7a 4490
Rpl24 4486
Rps25 4351
Rps3a1 4213
Rpl14 4029
Rpl32 4023
Rpl13 3984
Rps17 3941
Rps11 3935
Rpl18a 3930
Uba52 3877
Rpl12 3791
Rpl10 3756
Rps6 3748
Fau 3715
Rpl30 3436
Rps16 3426
Rpl31 3268
Magohb 3264
Rps14 3150
Rps24 3078
Rps15 3028
Rpl21 3025
Rps10 2980
Rpl27a 2893
Rpl36al 2752
Rps7 2732
Rpl19 2669
Rpl3 2655
Rpsa 2615
Rpl36 2444
Rpl11 2321
Rps5 2250
Smg5 2200
Rnps1 1881
Rpl18 1870
Ncbp2 1714
Smg9 1707
Rps27 1671
Rpl9 1495
Gspt2 1420
Rpl5 1299
Rps12 1219
Rpl36a 928
Rpl10a 896
Rpl4 874
Rps23 873
Rpl22 733
Ncbp1 631
Rpl27 529
Rpl13a 406
Ppp2r1a 137
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Pabpc1 -1124
Rpl7 -1359
Rps15a -1948
Magoh -2123
Smg8 -2133
Rpl39 -2432
Smg1 -2442
Ppp2ca -2530
Rpl17 -2701
Dcp1a -2710
Rpl15 -3334
Rpl22l1 -3376
Smg7 -3561
Smg6 -4276
Ppp2r2a -4887
Gspt1 -5235
Etf1 -6409
Pnrc2 -7733


AGGREPHAGY
set AGGREPHAGY
setSize 35
pANOVA 0.000519
s.dist 0.339
p.adjustANOVA 0.0164


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hsf1 7863
Prkn 7559
Tubb4a 7515
Vim 7139
Tubb3 7127
Dynll2 6859
Hdac6 6803
Rps27a 5855
Tubb6 5564
Cftr 4730
Vcp 4710
Park7 4551
Dync1h1 4206
Uba52 3877
Tuba1b 3389
Ubc 3090
Tuba4a 2984
Pcnt 2633
Ubb 2616
Arl13b 1724

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsf1 7863
Prkn 7559
Tubb4a 7515
Vim 7139
Tubb3 7127
Dynll2 6859
Hdac6 6803
Rps27a 5855
Tubb6 5564
Cftr 4730
Vcp 4710
Park7 4551
Dync1h1 4206
Uba52 3877
Tuba1b 3389
Ubc 3090
Tuba4a 2984
Pcnt 2633
Ubb 2616
Arl13b 1724
Tubb4b 1268
Dync1li1 1234
Tubb2a 983
Tuba8 724
Tubb2b 597
Dync1i1 565
Ift88 268
Ube2v1 -76
Tuba1c -502
Tuba1a -1499
Dynll1 -2178
Dync1i2 -2461
Dync1li2 -3018
Hsp90aa1 -5316
Ube2n -6199


ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
set ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
setSize 10
pANOVA 0.0637
s.dist -0.339
p.adjustANOVA 0.448


Top enriched genes
Top 20 genes
GeneID Gene Rank
Angptl4 -8438
Lpl -8375
Creb3l3 -7989
Mbtps2 -7344
Pcsk5 -5809
Mbtps1 -2775
Lmf2 1838
Lmf1 1893
Furin 2199
Pcsk6 2269

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Angptl4 -8438
Lpl -8375
Creb3l3 -7989
Mbtps2 -7344
Pcsk5 -5809
Mbtps1 -2775
Lmf2 1838
Lmf1 1893
Furin 2199
Pcsk6 2269


COMPLEMENT CASCADE
set COMPLEMENT CASCADE
setSize 22
pANOVA 0.00601
s.dist 0.338
p.adjustANOVA 0.114


Top enriched genes
Top 20 genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6968
Serping1 6863
Masp2 5997
C4b 4906
Clu 4791
C1qc 4384
Cd46 4243
C8g 3015
C1qa 3002
Masp1 2827
Cfh 2571
Cr1l 1929
Pros1 1028
Cd81 870
Cd55 767
Gzmm -547
Cd59b -1263
C3ar1 -2347

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6968
Serping1 6863
Masp2 5997
C4b 4906
Clu 4791
C1qc 4384
Cd46 4243
C8g 3015
C1qa 3002
Masp1 2827
Cfh 2571
Cr1l 1929
Pros1 1028
Cd81 870
Cd55 767
Gzmm -547
Cd59b -1263
C3ar1 -2347
Vtn -4405
Cfb -7717


ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS
set ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS
setSize 22
pANOVA 0.00603
s.dist 0.338
p.adjustANOVA 0.114


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pla2g6 7864
Plpp4 7854
Itpr3 7751
Prkcd 7667
Plcg1 7469
Pld1 6610
Fcgr3 5698
Itpr2 5109
Fcgr1 5037
Pld2 5002
Plpp5 3071
Plcg2 2456
Pik3r2 1778
Pik3ca 1399
Pld3 488
Ahcyl1 -536
Pld4 -741
Pik3r1 -2777
Syk -2936
Pik3cb -3284

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pla2g6 7864
Plpp4 7854
Itpr3 7751
Prkcd 7667
Plcg1 7469
Pld1 6610
Fcgr3 5698
Itpr2 5109
Fcgr1 5037
Pld2 5002
Plpp5 3071
Plcg2 2456
Pik3r2 1778
Pik3ca 1399
Pld3 488
Ahcyl1 -536
Pld4 -741
Pik3r1 -2777
Syk -2936
Pik3cb -3284
Itpr1 -3736
Prkce -7798


MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS
set MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS
setSize 18
pANOVA 0.0132
s.dist -0.337
p.adjustANOVA 0.179


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptpn4 -8441
Slc2a3 -8428
Oprk1 -8305
Met -7793
Creb1 -7648
Gria2 -7585
Grin2a -7390
Grin2b -6593
Mecp2 -5263
Hdac2 -4520
Trpc3 -3240
Gprin1 -2852
Sin3a -516
Oprm1 -230
Notch1 4061
Ptpn1 4217
Hdac1 4226
Fkbp5 7973

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn4 -8441
Slc2a3 -8428
Oprk1 -8305
Met -7793
Creb1 -7648
Gria2 -7585
Grin2a -7390
Grin2b -6593
Mecp2 -5263
Hdac2 -4520
Trpc3 -3240
Gprin1 -2852
Sin3a -516
Oprm1 -230
Notch1 4061
Ptpn1 4217
Hdac1 4226
Fkbp5 7973


CROSSLINKING OF COLLAGEN FIBRILS
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 14
pANOVA 0.029
s.dist 0.337
p.adjustANOVA 0.295


Top enriched genes
Top 20 genes
GeneID Gene Rank
Bmp1 7814
Col1a2 7493
Loxl3 7067
Col4a2 5672
Pcolce 4734
Col1a1 2600
Col4a5 2487
Col4a3 1851
Loxl1 1237
Tll2 1167
Pxdn 1010
Col4a1 -844
Tll1 -3737
Lox -4660

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bmp1 7814
Col1a2 7493
Loxl3 7067
Col4a2 5672
Pcolce 4734
Col1a1 2600
Col4a5 2487
Col4a3 1851
Loxl1 1237
Tll2 1167
Pxdn 1010
Col4a1 -844
Tll1 -3737
Lox -4660


SEMA4D IN SEMAPHORIN SIGNALING
set SEMA4D IN SEMAPHORIN SIGNALING
setSize 24
pANOVA 0.00467
s.dist 0.334
p.adjustANOVA 0.0974


Top enriched genes
Top 20 genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7494
Limk2 7422
Plxnb1 6904
Limk1 6630
Myh9 6344
Rras 6069
Rhoc 5773
Rnd1 5409
Myl6 4896
Myl12b 4332
Myh10 3505
Arhgap35 2432
Arhgef11 2058
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2060

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7494
Limk2 7422
Plxnb1 6904
Limk1 6630
Myh9 6344
Rras 6069
Rhoc 5773
Rnd1 5409
Myl6 4896
Myl12b 4332
Myh10 3505
Arhgap35 2432
Arhgef11 2058
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2060
Rhoa -3488
Rhob -5013
Rac1 -7095
Met -7793


ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING
set ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING
setSize 21
pANOVA 0.00852
s.dist -0.332
p.adjustANOVA 0.14


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mapk1 -8630
Creb1 -7648
Akt3 -7430
Btc -6800
Cdkn1b -6708
Uhmk1 -6501
Elk1 -5301
Foxo3 -5230
Xpo1 -4810
Ccnd1 -4631
Egf -4467
Tgfa -3525
Fos -2720
Srf -1841
Ptk2 -1712
Mapk3 -652
Egfr -281
Akt2 1548
Hbegf 1768
Akt1 2473

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk1 -8630
Creb1 -7648
Akt3 -7430
Btc -6800
Cdkn1b -6708
Uhmk1 -6501
Elk1 -5301
Foxo3 -5230
Xpo1 -4810
Ccnd1 -4631
Egf -4467
Tgfa -3525
Fos -2720
Srf -1841
Ptk2 -1712
Mapk3 -652
Egfr -281
Akt2 1548
Hbegf 1768
Akt1 2473
Bcl2 6066


SELENOAMINO ACID METABOLISM
set SELENOAMINO ACID METABOLISM
setSize 108
pANOVA 2.66e-09
s.dist 0.332
p.adjustANOVA 4.44e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ahcy 7694
Rps28 7598
Rps8 7451
Gnmt 7448
Rpl26 7361
Rpl28 7126
Rpl38 6636
Sars 6631
Rplp2 6621
Rps29 6611
Aimp2 6288
Rpl35 6267
Mars1 6192
Rpl23a 6157
Secisbp2 6010
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ahcy 7694
Rps28 7598
Rps8 7451
Gnmt 7448
Rpl26 7361
Rpl28 7126
Rpl38 6636
Sars 6631
Rplp2 6621
Rps29 6611
Aimp2 6288
Rpl35 6267
Mars1 6192
Rpl23a 6157
Secisbp2 6010
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533
Rpl37 5532
Rps19 5402
Rpl6 5383
Rps18 5261
Rpl8 5183
Rps27l 4782
Rpl35a 4750
Rplp1 4498
Rpl7a 4490
Rpl24 4486
Rps25 4351
Rps3a1 4213
Rpl14 4029
Rpl32 4023
Rpl13 3984
Rps17 3941
Rps11 3935
Rpl18a 3930
Uba52 3877
Rpl12 3791
Rpl10 3756
Rps6 3748
Fau 3715
Rpl30 3436
Rps16 3426
Iars 3410
Rpl31 3268
Rps14 3150
Rps24 3078
Rps15 3028
Rpl21 3025
Rps10 2980
Rpl27a 2893
Rpl36al 2752
Rps7 2732
Cbs 2676
Rpl19 2669
Rpl3 2655
Rpsa 2615
Eprs 2606
Rpl36 2444
Rpl11 2321
Rps5 2250
Rpl18 1870
Rps27 1671
Rpl9 1495
Aimp1 1376
Rpl5 1299
Rps12 1219
Papss1 1046
Rpl36a 928
Scly 915
Rpl10a 896
Rpl4 874
Rps23 873
Rpl22 733
Rpl27 529
Rpl13a 406
Eefsec 40
Rps20 -240
Kars -285
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Eef1e1 -1262
Cth -1320
Rpl7 -1359
Lars -1629
Rps15a -1948
Rpl39 -2432
Rpl17 -2701
Rars -3019
Qars -3273
Rpl15 -3334
Gsr -3358
Rpl22l1 -3376
Pstk -3571
Txnrd1 -3585
Papss2 -5734
Sepsecs -6612
Dars -7285
Hnmt -7350
Sephs2 -7624


P75NTR SIGNALS VIA NF KB
set P75NTR SIGNALS VIA NF KB
setSize 16
pANOVA 0.025
s.dist 0.324
p.adjustANOVA 0.272


Top enriched genes
Top 20 genes
GeneID Gene Rank
Myd88 6718
Ikbkb 6595
Nfkb1 6577
Irak1 6338
Rps27a 5855
Ngfr 5543
Uba52 3877
Ubc 3090
Ubb 2616
Ngf 2469
Nfkbia 2119
Sqstm1 728
Rela 29
Ripk2 -3195
Traf6 -3829
Prkci -8596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myd88 6718
Ikbkb 6595
Nfkb1 6577
Irak1 6338
Rps27a 5855
Ngfr 5543
Uba52 3877
Ubc 3090
Ubb 2616
Ngf 2469
Nfkbia 2119
Sqstm1 728
Rela 29
Ripk2 -3195
Traf6 -3829
Prkci -8596


ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS
set ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS
setSize 17
pANOVA 0.0225
s.dist -0.32
p.adjustANOVA 0.257


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdkn1a -8508
E2f3 -6817
Cdkn1b -6708
Rb1 -6357
Ccne2 -5715
E2f2 -5141
E2f1 -4659
Ccnd2 -4636
Ccnd1 -4631
Cdkn1c -4604
Tfdp2 -3113
Cdk6 -2301
Tfdp1 -2274
Cdk4 2012
Ccne1 2946
Cdk2 2991
Ccnd3 4934

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdkn1a -8508
E2f3 -6817
Cdkn1b -6708
Rb1 -6357
Ccne2 -5715
E2f2 -5141
E2f1 -4659
Ccnd2 -4636
Ccnd1 -4631
Cdkn1c -4604
Tfdp2 -3113
Cdk6 -2301
Tfdp1 -2274
Cdk4 2012
Ccne1 2946
Cdk2 2991
Ccnd3 4934


CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
set CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
setSize 10
pANOVA 0.0805
s.dist -0.319
p.adjustANOVA 0.479


Top enriched genes
Top 20 genes
GeneID Gene Rank
Casp3 -7554
Dcc -7424
Unc5b -6260
Appl1 -5630
Dapk2 -4728
Casp9 -4452
Maged1 -3231
Unc5a -2136
Dapk1 4835
Dapk3 5683

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Casp3 -7554
Dcc -7424
Unc5b -6260
Appl1 -5630
Dapk2 -4728
Casp9 -4452
Maged1 -3231
Unc5a -2136
Dapk1 4835
Dapk3 5683


ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
set ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
setSize 51
pANOVA 8.15e-05
s.dist 0.319
p.adjustANOVA 0.00352


Top enriched genes
Top 20 genes
GeneID Gene Rank
Bmp1 7814
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7493
Loxl3 7067
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Col6a2 6294
Plec 6234
Col3a1 5987
Col6a1 5962
Col4a2 5672
Ctsl 4854
Pcolce 4734
Col6a3 4622
Col15a1 4607

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bmp1 7814
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7493
Loxl3 7067
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Col6a2 6294
Plec 6234
Col3a1 5987
Col6a1 5962
Col4a2 5672
Ctsl 4854
Pcolce 4734
Col6a3 4622
Col15a1 4607
Col9a3 3790
Col18a1 3051
Col24a1 2998
Cd151 2680
Col1a1 2600
Col4a5 2487
Col17a1 2391
Col6a5 2357
Mmp9 1955
Col4a3 1851
Dst 1524
Lamb3 1436
Loxl1 1237
Col11a1 1223
Tll2 1167
Pxdn 1010
Col14a1 -449
Itgb4 -468
Col8a1 -758
Col4a1 -844
Itga6 -930
Col5a1 -939
Ctsb -1722
Ctss -1914
Tll1 -3737
Col9a1 -4503
Lox -4660
Col6a6 -5130
Lamc2 -5813
Col8a2 -7556
Lama3 -8651


SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
set SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize 106
pANOVA 1.54e-08
s.dist 0.318
p.adjustANOVA 1.79e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps28 7598
Rps8 7451
Rpl26 7361
Rpl28 7126
Rpl38 6636
Rplp2 6621
Rps29 6611
Rpl35 6267
Rpl23a 6157
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533
Rpl37 5532
Rps19 5402

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps28 7598
Rps8 7451
Rpl26 7361
Rpl28 7126
Rpl38 6636
Rplp2 6621
Rps29 6611
Rpl35 6267
Rpl23a 6157
Rps13 5970
Rps27a 5855
Rps21 5717
Rps2 5695
Rpl23 5635
Rps9 5595
Rpl37a 5547
Rps4x 5535
Rps26 5533
Rpl37 5532
Rps19 5402
Rpl6 5383
Rps18 5261
Rpl8 5183
Srp72 5119
Srpr 4814
Rps27l 4782
Rpl35a 4750
Rplp1 4498
Rpl7a 4490
Rpl24 4486
Rps25 4351
Rps3a1 4213
Sec11c 4178
Rpl14 4029
Rpl32 4023
Rpl13 3984
Rps17 3941
Rps11 3935
Rpl18a 3930
Uba52 3877
Srprb 3807
Rpl12 3791
Rpl10 3756
Rps6 3748
Fau 3715
Rpl30 3436
Rps16 3426
Srp19 3358
Rpl31 3268
Sec11a 3242
Rps14 3150
Rps24 3078
Rps15 3028
Rpl21 3025
Rps10 2980
Rpl27a 2893
Rpl36al 2752
Rps7 2732
Rpl19 2669
Rpl3 2655
Rpsa 2615
Rpl36 2444
Rpl11 2321
Rps5 2250
Rpl18 1870
Rpn2 1762
Sec61a2 1737
Rps27 1671
Rpl9 1495
Rpl5 1299
Rps12 1219
Sec61b 1078
Srp68 979
Srp14 948
Rpl36a 928
Rpl10a 896
Rpl4 874
Rps23 873
Spcs1 765
Rpl22 733
Rpl27 529
Rpl13a 406
Ssr4 -188
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Spcs2 -1146
Rpl7 -1359
Ddost -1478
Rps15a -1948
Sec61a1 -2417
Rpl39 -2432
Ssr2 -2656
Rpl17 -2701
Srp9 -3124
Rpl15 -3334
Rpl22l1 -3376
Rpn1 -4202
Sec61g -4279
Ssr1 -5678
Srp54a -5703
Ssr3 -5772
Spcs3 -7103
Tram1 -8162


FERTILIZATION
set FERTILIZATION
setSize 12
pANOVA 0.0567
s.dist 0.318
p.adjustANOVA 0.433


Top enriched genes
Top 20 genes
GeneID Gene Rank
Izumo4 7533
Catsperg1 6965
Ovgp1 6810
Catsperd 6039
Adam21 4739
Catsperg2 4264
Catsper2 2373
Kcnu1 1705
Acr 620
B4galt1 -3845
Cd9 -4538
Hvcn1 -5557

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Izumo4 7533
Catsperg1 6965
Ovgp1 6810
Catsperd 6039
Adam21 4739
Catsperg2 4264
Catsper2 2373
Kcnu1 1705
Acr 620
B4galt1 -3845
Cd9 -4538
Hvcn1 -5557


POST CHAPERONIN TUBULIN FOLDING PATHWAY
set POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize 17
pANOVA 0.0236
s.dist 0.317
p.adjustANOVA 0.262


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4a 7515
Tubb3 7127
Tubb6 5564
Arl2 4777
Tbcb 4620
Tbca 4004
Tuba1b 3389
Tuba4a 2984
Tbcd 2218
Tubb4b 1268
Tubb2a 983
Tuba8 724
Tubb2b 597
Tbcc -144
Tuba1c -502
Tuba1a -1499
Tbce -5315

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 7515
Tubb3 7127
Tubb6 5564
Arl2 4777
Tbcb 4620
Tbca 4004
Tuba1b 3389
Tuba4a 2984
Tbcd 2218
Tubb4b 1268
Tubb2a 983
Tuba8 724
Tubb2b 597
Tbcc -144
Tuba1c -502
Tuba1a -1499
Tbce -5315


TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
set TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize 13
pANOVA 0.0477
s.dist 0.317
p.adjustANOVA 0.387


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4a 7515
Tubb3 7127
Tubb6 5564
Tuba1b 3389
Tuba4a 2984
Gjb2 1873
Tubb4b 1268
Tubb2a 983
Tuba8 724
Tubb2b 597
Tuba1c -502
Gja1 -720
Tuba1a -1499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 7515
Tubb3 7127
Tubb6 5564
Tuba1b 3389
Tuba4a 2984
Gjb2 1873
Tubb4b 1268
Tubb2a 983
Tuba8 724
Tubb2b 597
Tuba1c -502
Gja1 -720
Tuba1a -1499


CD28 DEPENDENT VAV1 PATHWAY
set CD28 DEPENDENT VAV1 PATHWAY
setSize 11
pANOVA 0.0686
s.dist -0.317
p.adjustANOVA 0.448


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pak1 -7267
Rac1 -7095
Cd86 -6958
Cdc42 -6791
Lck -5245
Fyn -4006
Pak3 -3693
Grb2 -3236
Pak2 -2271
Cd80 5007
Vav1 7763

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pak1 -7267
Rac1 -7095
Cd86 -6958
Cdc42 -6791
Lck -5245
Fyn -4006
Pak3 -3693
Grb2 -3236
Pak2 -2271
Cd80 5007
Vav1 7763


NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
set NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 11
pANOVA 0.0707
s.dist -0.315
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hes1 -8398
Creb1 -7648
Rbpj -6452
Fcer2a -6104
Mamld1 -6046
Maml1 -5815
Maml2 -3710
Ep300 -801
Notch2 1344
Maml3 3510
Hes5 6552

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hes1 -8398
Creb1 -7648
Rbpj -6452
Fcer2a -6104
Mamld1 -6046
Maml1 -5815
Maml2 -3710
Ep300 -801
Notch2 1344
Maml3 3510
Hes5 6552


INSULIN PROCESSING
set INSULIN PROCESSING
setSize 24
pANOVA 0.00786
s.dist -0.313
p.adjustANOVA 0.133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Exoc5 -8628
Exoc6 -8582
Slc30a5 -8069
Pcsk2 -7693
Exoc2 -6923
Slc30a7 -6646
Ero1a -6455
Myrip -5649
Kif5c -5369
Cpe -5082
Myo5a -5059
Kif5b -3442
Exoc1 -3323
Ero1b -2872
Rab27a -2782
Kif5a -2300
Pcsk1 -1678
Slc30a6 -1209
Vamp2 -235
Exoc3 451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Exoc5 -8628
Exoc6 -8582
Slc30a5 -8069
Pcsk2 -7693
Exoc2 -6923
Slc30a7 -6646
Ero1a -6455
Myrip -5649
Kif5c -5369
Cpe -5082
Myo5a -5059
Kif5b -3442
Exoc1 -3323
Ero1b -2872
Rab27a -2782
Kif5a -2300
Pcsk1 -1678
Slc30a6 -1209
Vamp2 -235
Exoc3 451
Stx1a 1992
Exoc8 4507
Exoc4 4819
Exoc7 7292


RHO GTPASES ACTIVATE ROCKS
set RHO GTPASES ACTIVATE ROCKS
setSize 19
pANOVA 0.0183
s.dist 0.313
p.adjustANOVA 0.227


Top enriched genes
Top 20 genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7494
Limk2 7422
Limk1 6630
Myh9 6344
Rhoc 5773
Myl6 4896
Myl12b 4332
Myh10 3505
Ppp1r12a 1974
Ppp1r12b 1692
Cfl1 3
Rock2 -657
Rock1 -1112
Rhoa -3488
Rhob -5013
Ppp1cb -6010
Pak1 -7267

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7494
Limk2 7422
Limk1 6630
Myh9 6344
Rhoc 5773
Myl6 4896
Myl12b 4332
Myh10 3505
Ppp1r12a 1974
Ppp1r12b 1692
Cfl1 3
Rock2 -657
Rock1 -1112
Rhoa -3488
Rhob -5013
Ppp1cb -6010
Pak1 -7267


PEXOPHAGY
set PEXOPHAGY
setSize 11
pANOVA 0.0753
s.dist 0.31
p.adjustANOVA 0.468


Top enriched genes
Top 20 genes
GeneID Gene Rank
Epas1 7122
Pex5 5948
Rps27a 5855
Uba52 3877
Ubc 3090
Ubb 2616
Map1lc3b 2185
Nbr1 1547
Sqstm1 728
Usp30 -445
Atm -8415

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Epas1 7122
Pex5 5948
Rps27a 5855
Uba52 3877
Ubc 3090
Ubb 2616
Map1lc3b 2185
Nbr1 1547
Sqstm1 728
Usp30 -445
Atm -8415


TIGHT JUNCTION INTERACTIONS
set TIGHT JUNCTION INTERACTIONS
setSize 18
pANOVA 0.0231
s.dist -0.309
p.adjustANOVA 0.259


Top enriched genes
Top 20 genes
GeneID Gene Rank
Crb3 -8748
Prkci -8596
Cldn3 -8209
Cldn2 -7404
Cldn1 -6904
Pard6b -5978
Pard6g -5914
Pard6a -5896
Cldn5 -4584
Cldn10 -3265
Pals1 -2579
Cldn23 -1581
Cldn12 -1182
F11r 462
Cldn11 1023
Pard3 3802
Cldn14 5170
Patj 6290

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crb3 -8748
Prkci -8596
Cldn3 -8209
Cldn2 -7404
Cldn1 -6904
Pard6b -5978
Pard6g -5914
Pard6a -5896
Cldn5 -4584
Cldn10 -3265
Pals1 -2579
Cldn23 -1581
Cldn12 -1182
F11r 462
Cldn11 1023
Pard3 3802
Cldn14 5170
Patj 6290


E2F MEDIATED REGULATION OF DNA REPLICATION
set E2F MEDIATED REGULATION OF DNA REPLICATION
setSize 19
pANOVA 0.0204
s.dist -0.307
p.adjustANOVA 0.236


Top enriched genes
Top 20 genes
GeneID Gene Rank
Orc3 -8141
Ppp2cb -8046
Orc5 -7741
Orc4 -6545
Rb1 -6357
Orc6 -5381
E2f1 -4659
Tfdp2 -3113
Mcm8 -2887
Prim1 -2877
Ppp2ca -2530
Tfdp1 -2274
Orc2 -1710
Ppp2r1b -941
Prim2 -243
Ppp2r1a 137
Pola2 981
Pola1 1145
Ppp2r3d 4407

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Orc3 -8141
Ppp2cb -8046
Orc5 -7741
Orc4 -6545
Rb1 -6357
Orc6 -5381
E2f1 -4659
Tfdp2 -3113
Mcm8 -2887
Prim1 -2877
Ppp2ca -2530
Tfdp1 -2274
Orc2 -1710
Ppp2r1b -941
Prim2 -243
Ppp2r1a 137
Pola2 981
Pola1 1145
Ppp2r3d 4407


P75NTR RECRUITS SIGNALLING COMPLEXES
set P75NTR RECRUITS SIGNALLING COMPLEXES
setSize 13
pANOVA 0.0552
s.dist 0.307
p.adjustANOVA 0.426


Top enriched genes
Top 20 genes
GeneID Gene Rank
Myd88 6718
Ikbkb 6595
Irak1 6338
Rps27a 5855
Ngfr 5543
Uba52 3877
Ubc 3090
Ubb 2616
Ngf 2469
Sqstm1 728
Ripk2 -3195
Traf6 -3829
Prkci -8596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myd88 6718
Ikbkb 6595
Irak1 6338
Rps27a 5855
Ngfr 5543
Uba52 3877
Ubc 3090
Ubb 2616
Ngf 2469
Sqstm1 728
Ripk2 -3195
Traf6 -3829
Prkci -8596


REDUCTION OF CYTOSOLIC CA LEVELS
set REDUCTION OF CYTOSOLIC CA LEVELS
setSize 11
pANOVA 0.0803
s.dist -0.305
p.adjustANOVA 0.479


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc8a1 -8586
Calm1 -6804
Atp2b4 -6664
Atp2a2 -5585
Atp2b1 -4622
Sri -3793
Atp2a3 -1039
Slc8a2 -990
Atp2b3 -261
Atp2b2 400
Slc8a3 5316

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc8a1 -8586
Calm1 -6804
Atp2b4 -6664
Atp2a2 -5585
Atp2b1 -4622
Sri -3793
Atp2a3 -1039
Slc8a2 -990
Atp2b3 -261
Atp2b2 400
Slc8a3 5316


RNA POLYMERASE II TRANSCRIPTION TERMINATION
set RNA POLYMERASE II TRANSCRIPTION TERMINATION
setSize 65
pANOVA 2.34e-05
s.dist 0.303
p.adjustANOVA 0.00114


Top enriched genes
Top 20 genes
GeneID Gene Rank
Srsf4 7950
Snrpf 7557
Srsf9 7514
Cpsf1 7481
Dhx38 7463
Pabpn1 7403
Srsf2 7202
Ddx39a 7176
U2af1 7004
Alyref 6746
Srsf6 6720
Cpsf4 6691
Srrm1 6372
Cpsf7 6327
Sympk 5958
U2af1l4 5882
Ddx39b 5836
Upf3b 5812
Zc3h11a 5702
Snrpb 5628

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Srsf4 7950
Snrpf 7557
Srsf9 7514
Cpsf1 7481
Dhx38 7463
Pabpn1 7403
Srsf2 7202
Ddx39a 7176
U2af1 7004
Alyref 6746
Srsf6 6720
Cpsf4 6691
Srrm1 6372
Cpsf7 6327
Sympk 5958
U2af1l4 5882
Ddx39b 5836
Upf3b 5812
Zc3h11a 5702
Snrpb 5628
U2af2 5492
Cstf3 5340
Srsf1 5314
Srsf11 5306
Rbm8a 5295
Sarnp 5126
Casc3 5114
Thoc6 4877
Eif4a3 4763
Thoc5 4462
Zfp473 4031
Cstf2 3655
Cpsf3 3474
Magohb 3264
Slu7 3126
Srsf5 2853
Poldip3 2056
Rnps1 1881
Ncbp2 1714
Snrpg 1228
Cstf1 1128
Thoc1 1116
Fip1l1 1014
Ncbp1 631
Papola 592
Wdr33 242
Snrpe 67
Chtop -246
Thoc7 -394
Lsm10 -1318
Srsf7 -1589
Magoh -2123
Nudt21 -2127
Cdc40 -2473
Pcf11 -2881
Srsf3 -3340
Thoc2 -3965
Lsm11 -5022
Snrpd3 -6249
Cstf2t -7253
Clp1 -7569
Thoc3 -7896
Slbp -7908
Cpsf2 -8203
Fyttd1 -8539


COLLAGEN DEGRADATION
set COLLAGEN DEGRADATION
setSize 51
pANOVA 0.000186
s.dist 0.303
p.adjustANOVA 0.00724


Top enriched genes
Top 20 genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col11a2 7685
Col12a1 7671
Col1a2 7493
Col16a1 7369
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Col6a2 6294
Col3a1 5987
Col6a1 5962
Mmp19 5797
Col4a2 5672
Ctsl 4854
Col6a3 4622
Col15a1 4607
Mmp15 4536

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col11a2 7685
Col12a1 7671
Col1a2 7493
Col16a1 7369
Col2a1 7014
Col5a2 6996
Col7a1 6816
Col5a3 6713
Col6a2 6294
Col3a1 5987
Col6a1 5962
Mmp19 5797
Col4a2 5672
Ctsl 4854
Col6a3 4622
Col15a1 4607
Mmp15 4536
Ctsk 4051
Col9a3 3790
Adam9 3082
Col18a1 3051
Tmprss6 2869
Col1a1 2600
Col4a5 2487
Col17a1 2391
Col6a5 2357
Furin 2199
Mmp9 1955
Col4a3 1851
Col11a1 1223
Phykpl 93
Col14a1 -449
Col19a1 -590
Ctsd -733
Col8a1 -758
Adam17 -843
Col4a1 -844
Col5a1 -939
Ctsb -1722
Mmp14 -3451
Col23a1 -3679
Col9a1 -4503
Col6a6 -5130
Col25a1 -5181
Mmp2 -5449
Adam10 -5749
Mmp11 -7538
Col8a2 -7556


LYSOSPHINGOLIPID AND LPA RECEPTORS
set LYSOSPHINGOLIPID AND LPA RECEPTORS
setSize 12
pANOVA 0.0702
s.dist -0.302
p.adjustANOVA 0.449


Top enriched genes
Top 20 genes
GeneID Gene Rank
Plppr5 -8371
Plppr4 -7718
S1pr1 -6233
Plppr1 -6120
S1pr2 -5472
Lpar1 -3233
Lpar2 -2740
Plppr2 -2018
S1pr5 -1546
S1pr4 -703
S1pr3 2255
Plppr3 6569

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plppr5 -8371
Plppr4 -7718
S1pr1 -6233
Plppr1 -6120
S1pr2 -5472
Lpar1 -3233
Lpar2 -2740
Plppr2 -2018
S1pr5 -1546
S1pr4 -703
S1pr3 2255
Plppr3 6569


CGMP EFFECTS
set CGMP EFFECTS
setSize 15
pANOVA 0.0431
s.dist -0.302
p.adjustANOVA 0.37


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pde1a -8709
Kcnma1 -7642
Prkg1 -6665
Kcnmb1 -5797
Pde11a -4244
Itpr1 -3736
Pde2a -3719
Pde9a -2938
Kcnmb4 -2885
Pde10a -2225
Pde5a -1892
Pde1b 313
Kcnmb2 1568
Irag1 2033
Prkg2 2418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pde1a -8709
Kcnma1 -7642
Prkg1 -6665
Kcnmb1 -5797
Pde11a -4244
Itpr1 -3736
Pde2a -3719
Pde9a -2938
Kcnmb4 -2885
Pde10a -2225
Pde5a -1892
Pde1b 313
Kcnmb2 1568
Irag1 2033
Prkg2 2418


SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
set SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
setSize 13
pANOVA 0.0601
s.dist 0.301
p.adjustANOVA 0.447


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptgis 7770
Slc27a2 6339
Rxra 5873
Cyp27a1 5851
Acot8 5804
Hsd17b4 4960
Hsd3b7 4666
Scp2 1615
Slc27a5 717
Cyp7b1 -698
Ncoa2 -4282
Ncoa1 -5339
Amacr -5717

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptgis 7770
Slc27a2 6339
Rxra 5873
Cyp27a1 5851
Acot8 5804
Hsd17b4 4960
Hsd3b7 4666
Scp2 1615
Slc27a5 717
Cyp7b1 -698
Ncoa2 -4282
Ncoa1 -5339
Amacr -5717


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.4            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] highr_0.11              later_1.3.2             DelayedArray_0.30.1    
## [28] BiocParallel_1.38.0     parallel_4.4.0          R6_2.5.1               
## [31] bslib_0.7.0             stringi_1.8.4           RColorBrewer_1.1-3     
## [34] jquerylib_0.1.4         Rcpp_1.0.12             assertthat_0.2.1       
## [37] knitr_1.47              httpuv_1.6.15           Matrix_1.7-0           
## [40] tidyselect_1.2.1        rstudioapi_0.16.0       abind_1.4-5            
## [43] yaml_2.3.8              codetools_0.2-20        lattice_0.22-6         
## [46] plyr_1.8.9              withr_3.0.0             shiny_1.8.1.1          
## [49] evaluate_0.23           polyclip_1.10-6         ggstats_0.6.0          
## [52] xml2_1.3.6              pillar_1.9.0            KernSmooth_2.23-24     
## [55] generics_0.1.3          munsell_0.5.1           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [61] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [64] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [70] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [73] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [76] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [79] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [82] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report