date generated: 2024-06-05

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik -3.3814425 -2.2697336
0610009E02Rik -0.3557659 -0.3519839
0610009L18Rik -0.8507498 -0.9139963
0610010K14Rik 1.2510787 -0.1751685
0610012G03Rik 3.9729326 0.5678859
0610030E20Rik 0.1581737 1.4359134

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 16806
duplicated_genes_present 0
num_profile_genes_in_sets 8269
num_profile_genes_not_in_sets 8537
profile_pearson_correl 0.82048
profile_spearman_correl 0.81468

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 434
num_genesets_included 1170

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 281

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 4.71e-04 3.44e-03 0.841 -0.531 -0.6530 1.46e-03 9.07e-05
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 2.92e-04 2.25e-03 0.828 -0.518 -0.6460 1.23e-03 5.49e-05
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 6.56e-03 3.10e-02 0.696 -0.455 -0.5270 6.39e-03 1.58e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.72e-02 6.53e-02 0.694 0.467 0.5140 1.05e-02 4.89e-03
APOPTOSIS INDUCED DNA FRAGMENTATION 10 2.25e-02 8.06e-02 0.678 -0.482 -0.4770 8.32e-03 9.07e-03
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 2.15e-02 7.81e-02 0.676 0.499 0.4560 6.31e-03 1.25e-02
CD28 DEPENDENT VAV1 PATHWAY 11 1.81e-02 6.82e-02 0.656 -0.439 -0.4880 1.17e-02 5.07e-03
CROSSLINKING OF COLLAGEN FIBRILS 15 4.17e-03 2.13e-02 0.639 0.494 0.4060 9.32e-04 6.43e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 2.16e-05 2.27e-04 0.639 -0.402 -0.4970 1.80e-04 3.56e-06
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 2.29e-08 4.87e-07 0.627 -0.295 -0.5540 4.46e-03 9.54e-08
PROCESSING AND ACTIVATION OF SUMO 10 2.95e-02 1.00e-01 0.598 -0.481 -0.3560 8.47e-03 5.14e-02
ACTIVATION OF SMO 16 9.09e-03 3.98e-02 0.594 0.432 0.4080 2.77e-03 4.70e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.92e-19 2.29e-17 0.590 -0.207 -0.5520 5.93e-03 2.21e-13
EUKARYOTIC TRANSLATION ELONGATION 87 1.03e-38 4.01e-36 0.587 -0.128 -0.5730 3.95e-02 2.34e-20
CRMPS IN SEMA3A SIGNALING 16 2.12e-03 1.25e-02 0.585 0.321 0.4890 2.62e-02 7.10e-04
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 2.05e-02 7.56e-02 0.583 0.446 0.3760 5.34e-03 1.91e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.50e-02 5.92e-02 0.578 0.365 0.4470 1.79e-02 3.76e-03
EUKARYOTIC TRANSLATION INITIATION 114 3.70e-40 2.16e-37 0.573 -0.168 -0.5480 2.02e-03 4.69e-24
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.51e-35 3.53e-33 0.568 -0.173 -0.5410 2.08e-03 6.18e-22
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 7.08e-02 1.91e-01 0.563 -0.383 -0.4120 3.58e-02 2.40e-02
NRAGE SIGNALS DEATH THROUGH JNK 55 1.44e-07 2.51e-06 0.559 0.348 0.4370 7.99e-06 2.02e-08
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 4.95e-33 8.28e-31 0.556 -0.151 -0.5350 1.15e-02 2.87e-19
SYNAPTIC ADHESION LIKE MOLECULES 21 3.80e-03 1.99e-02 0.554 0.362 0.4190 4.05e-03 8.81e-04
COHESIN LOADING ONTO CHROMATIN 10 4.92e-04 3.53e-03 0.554 -0.531 -0.1570 3.62e-03 3.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 2.21e-03 1.29e-02 0.552 -0.314 -0.4540 1.77e-02 6.20e-04
PROTEIN METHYLATION 17 1.36e-03 8.68e-03 0.541 -0.268 -0.4690 5.57e-02 8.07e-04
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 3.79e-02 1.24e-01 0.538 0.294 0.4500 1.07e-01 1.37e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.61e-03 1.92e-02 0.528 0.280 0.4470 4.54e-02 1.42e-03
COMPLEX I BIOGENESIS 56 1.46e-16 8.16e-15 0.515 -0.149 -0.4930 5.46e-02 1.67e-10
EARLY PHASE OF HIV LIFE CYCLE 13 5.21e-02 1.54e-01 0.515 -0.339 -0.3870 3.43e-02 1.56e-02
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.78e-10 9.04e-09 0.512 0.511 -0.0334 2.64e-04 8.11e-01
TRIGLYCERIDE CATABOLISM 14 9.18e-03 3.99e-02 0.510 -0.258 -0.4400 9.46e-02 4.37e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 9.61e-03 4.15e-02 0.509 -0.301 -0.4110 2.70e-02 2.54e-03
SELENOAMINO ACID METABOLISM 109 3.53e-31 4.13e-29 0.500 -0.135 -0.4820 1.53e-02 3.55e-18
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.58e-02 6.15e-02 0.500 -0.345 -0.3620 7.50e-03 5.12e-03
SIGNALING BY LEPTIN 10 3.65e-02 1.20e-01 0.498 0.247 0.4330 1.76e-01 1.78e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 6.77e-03 3.17e-02 0.498 -0.196 -0.4580 2.60e-01 8.53e-03
NCAM1 INTERACTIONS 40 1.22e-04 1.05e-03 0.498 0.313 0.3880 6.25e-04 2.19e-05
REPRESSION OF WNT TARGET GENES 14 4.08e-02 1.31e-01 0.495 0.390 0.3050 1.16e-02 4.78e-02
INTERLEUKIN 12 SIGNALING 37 4.61e-06 6.20e-05 0.494 -0.241 -0.4310 1.11e-02 5.68e-06
CELLULAR HEXOSE TRANSPORT 11 9.17e-02 2.30e-01 0.493 0.381 0.3130 2.88e-02 7.20e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 1.01e-03 6.82e-03 0.489 0.283 0.3990 9.59e-03 2.59e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 2.27e-10 8.03e-09 0.488 -0.201 -0.4450 1.06e-02 1.59e-08
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 3.12e-09 9.36e-08 0.487 -0.198 -0.4450 1.88e-02 1.30e-07
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 1.78e-02 6.72e-02 0.486 0.321 0.3640 1.29e-02 4.81e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 3.41e-10 1.08e-08 0.482 -0.211 -0.4330 5.02e-03 8.83e-09
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 4.33e-03 2.19e-02 0.481 0.303 0.3740 7.52e-03 9.71e-04
RUNX3 REGULATES NOTCH SIGNALING 13 5.89e-02 1.69e-01 0.480 0.293 0.3800 6.70e-02 1.76e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 6.69e-06 8.51e-05 0.480 0.326 0.3520 8.86e-06 1.65e-06
INTERLEUKIN 37 SIGNALING 17 1.89e-02 7.05e-02 0.477 0.277 0.3890 4.81e-02 5.53e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 4.71e-04 3.44e-03 0.84100 -0.531000 -0.653000 1.46e-03 9.07e-05
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 2.92e-04 2.25e-03 0.82800 -0.518000 -0.646000 1.23e-03 5.49e-05
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 6.56e-03 3.10e-02 0.69600 -0.455000 -0.527000 6.39e-03 1.58e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.72e-02 6.53e-02 0.69400 0.467000 0.514000 1.05e-02 4.89e-03
APOPTOSIS INDUCED DNA FRAGMENTATION 10 2.25e-02 8.06e-02 0.67800 -0.482000 -0.477000 8.32e-03 9.07e-03
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 2.15e-02 7.81e-02 0.67600 0.499000 0.456000 6.31e-03 1.25e-02
CD28 DEPENDENT VAV1 PATHWAY 11 1.81e-02 6.82e-02 0.65600 -0.439000 -0.488000 1.17e-02 5.07e-03
CROSSLINKING OF COLLAGEN FIBRILS 15 4.17e-03 2.13e-02 0.63900 0.494000 0.406000 9.32e-04 6.43e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 2.16e-05 2.27e-04 0.63900 -0.402000 -0.497000 1.80e-04 3.56e-06
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 2.29e-08 4.87e-07 0.62700 -0.295000 -0.554000 4.46e-03 9.54e-08
PROCESSING AND ACTIVATION OF SUMO 10 2.95e-02 1.00e-01 0.59800 -0.481000 -0.356000 8.47e-03 5.14e-02
ACTIVATION OF SMO 16 9.09e-03 3.98e-02 0.59400 0.432000 0.408000 2.77e-03 4.70e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.92e-19 2.29e-17 0.59000 -0.207000 -0.552000 5.93e-03 2.21e-13
EUKARYOTIC TRANSLATION ELONGATION 87 1.03e-38 4.01e-36 0.58700 -0.128000 -0.573000 3.95e-02 2.34e-20
CRMPS IN SEMA3A SIGNALING 16 2.12e-03 1.25e-02 0.58500 0.321000 0.489000 2.62e-02 7.10e-04
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 2.05e-02 7.56e-02 0.58300 0.446000 0.376000 5.34e-03 1.91e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.50e-02 5.92e-02 0.57800 0.365000 0.447000 1.79e-02 3.76e-03
EUKARYOTIC TRANSLATION INITIATION 114 3.70e-40 2.16e-37 0.57300 -0.168000 -0.548000 2.02e-03 4.69e-24
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.51e-35 3.53e-33 0.56800 -0.173000 -0.541000 2.08e-03 6.18e-22
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 7.08e-02 1.91e-01 0.56300 -0.383000 -0.412000 3.58e-02 2.40e-02
NRAGE SIGNALS DEATH THROUGH JNK 55 1.44e-07 2.51e-06 0.55900 0.348000 0.437000 7.99e-06 2.02e-08
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 4.95e-33 8.28e-31 0.55600 -0.151000 -0.535000 1.15e-02 2.87e-19
SYNAPTIC ADHESION LIKE MOLECULES 21 3.80e-03 1.99e-02 0.55400 0.362000 0.419000 4.05e-03 8.81e-04
COHESIN LOADING ONTO CHROMATIN 10 4.92e-04 3.53e-03 0.55400 -0.531000 -0.157000 3.62e-03 3.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 2.21e-03 1.29e-02 0.55200 -0.314000 -0.454000 1.77e-02 6.20e-04
PROTEIN METHYLATION 17 1.36e-03 8.68e-03 0.54100 -0.268000 -0.469000 5.57e-02 8.07e-04
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 3.79e-02 1.24e-01 0.53800 0.294000 0.450000 1.07e-01 1.37e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.61e-03 1.92e-02 0.52800 0.280000 0.447000 4.54e-02 1.42e-03
COMPLEX I BIOGENESIS 56 1.46e-16 8.16e-15 0.51500 -0.149000 -0.493000 5.46e-02 1.67e-10
EARLY PHASE OF HIV LIFE CYCLE 13 5.21e-02 1.54e-01 0.51500 -0.339000 -0.387000 3.43e-02 1.56e-02
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.78e-10 9.04e-09 0.51200 0.511000 -0.033400 2.64e-04 8.11e-01
TRIGLYCERIDE CATABOLISM 14 9.18e-03 3.99e-02 0.51000 -0.258000 -0.440000 9.46e-02 4.37e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 9.61e-03 4.15e-02 0.50900 -0.301000 -0.411000 2.70e-02 2.54e-03
SELENOAMINO ACID METABOLISM 109 3.53e-31 4.13e-29 0.50000 -0.135000 -0.482000 1.53e-02 3.55e-18
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.58e-02 6.15e-02 0.50000 -0.345000 -0.362000 7.50e-03 5.12e-03
SIGNALING BY LEPTIN 10 3.65e-02 1.20e-01 0.49800 0.247000 0.433000 1.76e-01 1.78e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 6.77e-03 3.17e-02 0.49800 -0.196000 -0.458000 2.60e-01 8.53e-03
NCAM1 INTERACTIONS 40 1.22e-04 1.05e-03 0.49800 0.313000 0.388000 6.25e-04 2.19e-05
REPRESSION OF WNT TARGET GENES 14 4.08e-02 1.31e-01 0.49500 0.390000 0.305000 1.16e-02 4.78e-02
INTERLEUKIN 12 SIGNALING 37 4.61e-06 6.20e-05 0.49400 -0.241000 -0.431000 1.11e-02 5.68e-06
CELLULAR HEXOSE TRANSPORT 11 9.17e-02 2.30e-01 0.49300 0.381000 0.313000 2.88e-02 7.20e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 1.01e-03 6.82e-03 0.48900 0.283000 0.399000 9.59e-03 2.59e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 2.27e-10 8.03e-09 0.48800 -0.201000 -0.445000 1.06e-02 1.59e-08
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 3.12e-09 9.36e-08 0.48700 -0.198000 -0.445000 1.88e-02 1.30e-07
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 1.78e-02 6.72e-02 0.48600 0.321000 0.364000 1.29e-02 4.81e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 3.41e-10 1.08e-08 0.48200 -0.211000 -0.433000 5.02e-03 8.83e-09
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 4.33e-03 2.19e-02 0.48100 0.303000 0.374000 7.52e-03 9.71e-04
RUNX3 REGULATES NOTCH SIGNALING 13 5.89e-02 1.69e-01 0.48000 0.293000 0.380000 6.70e-02 1.76e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 6.69e-06 8.51e-05 0.48000 0.326000 0.352000 8.86e-06 1.65e-06
INTERLEUKIN 37 SIGNALING 17 1.89e-02 7.05e-02 0.47700 0.277000 0.389000 4.81e-02 5.53e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.09e-01 2.58e-01 0.47600 0.303000 0.366000 8.16e-02 3.54e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 4.59e-11 1.92e-09 0.47500 -0.191000 -0.435000 1.14e-02 7.27e-09
METABOLISM OF POLYAMINES 58 5.41e-09 1.44e-07 0.47400 -0.220000 -0.419000 3.69e-03 3.34e-08
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 7.86e-02 2.08e-01 0.47000 -0.385000 -0.269000 2.70e-02 1.22e-01
RESPIRATORY ELECTRON TRANSPORT 102 5.30e-28 5.63e-26 0.47000 -0.111000 -0.456000 5.40e-02 1.61e-15
PROCESSING OF SMDT1 16 2.06e-03 1.22e-02 0.47000 -0.192000 -0.429000 1.85e-01 2.98e-03
METHYLATION 11 6.98e-02 1.90e-01 0.46700 -0.259000 -0.389000 1.37e-01 2.54e-02
PRE NOTCH PROCESSING IN GOLGI 18 3.86e-02 1.25e-01 0.46700 0.336000 0.325000 1.37e-02 1.69e-02
GLYCOGEN SYNTHESIS 14 4.79e-03 2.38e-02 0.46700 -0.191000 -0.426000 2.17e-01 5.75e-03
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 6.33e-02 1.78e-01 0.46600 0.278000 0.374000 8.25e-02 1.97e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 7.13e-08 1.32e-06 0.46500 0.456000 -0.091100 4.42e-03 5.70e-01
NONSENSE MEDIATED DECAY NMD 109 9.68e-26 8.09e-24 0.46400 -0.133000 -0.444000 1.65e-02 1.09e-15
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 8.19e-35 1.60e-32 0.46300 -0.146000 -0.439000 1.42e-03 6.55e-22
INTERACTION BETWEEN L1 AND ANKYRINS 27 5.39e-04 3.80e-03 0.46000 0.229000 0.399000 3.94e-02 3.37e-04
MET ACTIVATES RAP1 AND RAC1 11 5.13e-02 1.53e-01 0.45900 -0.395000 -0.232000 2.32e-02 1.82e-01
PYRUVATE METABOLISM 27 1.15e-03 7.49e-03 0.45800 -0.242000 -0.389000 2.95e-02 4.76e-04
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 4.34e-02 1.34e-01 0.45600 -0.222000 -0.399000 2.02e-01 2.20e-02
CRISTAE FORMATION 31 4.55e-08 8.88e-07 0.45400 -0.117000 -0.438000 2.61e-01 2.41e-05
ACTIVATION OF RAC1 13 4.92e-02 1.48e-01 0.45000 -0.378000 -0.244000 1.84e-02 1.28e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 1.12e-01 2.63e-01 0.44900 0.305000 0.329000 5.67e-02 4.02e-02
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 7.04e-04 4.81e-03 0.44800 -0.259000 -0.366000 8.02e-03 1.79e-04
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 5.50e-11 2.22e-09 0.44800 -0.149000 -0.423000 5.84e-02 7.73e-08
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 3.66e-32 5.35e-30 0.44700 -0.098400 -0.437000 5.77e-02 3.45e-17
PROTEIN UBIQUITINATION 69 9.19e-06 1.11e-04 0.44500 -0.295000 -0.333000 2.21e-05 1.77e-06
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 7.99e-03 3.57e-02 0.44100 -0.198000 -0.395000 1.71e-01 6.27e-03
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 10 1.20e-01 2.74e-01 0.44000 0.246000 0.365000 1.78e-01 4.54e-02
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 1.17e-03 7.63e-03 0.44000 0.355000 0.260000 2.77e-04 7.87e-03
STABILIZATION OF P53 55 2.25e-08 4.87e-07 0.43800 -0.185000 -0.397000 1.77e-02 3.63e-07
TRANSLESION SYNTHESIS BY POLH 19 2.59e-03 1.46e-02 0.43400 -0.185000 -0.393000 1.63e-01 3.01e-03
TRANSLATION 286 2.94e-66 3.44e-63 0.43400 -0.100000 -0.422000 3.69e-03 1.16e-34
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 6.53e-02 1.82e-01 0.43400 0.261000 0.346000 8.05e-02 2.02e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 4.90e-05 4.82e-04 0.43100 -0.090900 -0.422000 5.04e-01 1.95e-03
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 5.60e-02 1.63e-01 0.42900 0.351000 0.246000 1.85e-02 9.94e-02
COLLAGEN CHAIN TRIMERIZATION 39 1.52e-03 9.63e-03 0.42700 0.267000 0.333000 3.92e-03 3.17e-04
MITOCHONDRIAL TRANSLATION 93 8.25e-27 8.04e-25 0.42500 -0.051200 -0.421000 3.94e-01 2.14e-12
RORA ACTIVATES GENE EXPRESSION 18 1.07e-03 7.10e-03 0.42400 0.146000 0.398000 2.85e-01 3.46e-03
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 53 2.46e-04 1.96e-03 0.42300 0.273000 0.323000 5.93e-04 4.66e-05
SIGNALING BY FGFR4 IN DISEASE 10 1.83e-01 3.64e-01 0.42200 -0.335000 -0.257000 6.64e-02 1.59e-01
ORC1 REMOVAL FROM CHROMATIN 68 5.08e-08 9.74e-07 0.42200 -0.203000 -0.370000 3.74e-03 1.35e-07
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.05e-01 2.53e-01 0.42100 -0.240000 -0.347000 1.51e-01 3.77e-02
TRANSLESION SYNTHESIS BY POLK 17 6.35e-03 3.03e-02 0.42100 -0.178000 -0.382000 2.05e-01 6.43e-03
CHOLESTEROL BIOSYNTHESIS 24 1.65e-03 1.02e-02 0.42000 -0.191000 -0.374000 1.05e-01 1.52e-03
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 4.49e-36 1.31e-33 0.41900 -0.105000 -0.406000 1.80e-02 3.91e-20
IRAK4 DEFICIENCY TLR2 4 12 4.37e-02 1.35e-01 0.41900 -0.193000 -0.372000 2.47e-01 2.58e-02
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 1.11e-01 2.61e-01 0.41800 -0.227000 -0.351000 1.92e-01 4.40e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.94e-01 3.77e-01 0.41800 -0.330000 -0.256000 7.07e-02 1.61e-01
MITOTIC TELOPHASE CYTOKINESIS 13 2.01e-03 1.20e-02 0.41700 -0.405000 -0.101000 1.15e-02 5.27e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 1.74e-08 3.91e-07 0.41700 -0.184000 -0.374000 1.04e-02 1.79e-07
INTERLEUKIN 12 FAMILY SIGNALING 44 1.64e-05 1.85e-04 0.41600 -0.195000 -0.367000 2.56e-02 2.51e-05
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.52e-10 8.43e-09 0.41500 0.027700 -0.414000 8.07e-01 2.60e-04
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 5.83e-04 4.04e-03 0.41400 -0.268000 -0.315000 1.03e-03 1.17e-04
COLLAGEN FORMATION 78 1.79e-05 1.96e-04 0.41200 0.290000 0.294000 9.82e-06 7.34e-06
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.27e-09 1.44e-07 0.41200 -0.141000 -0.387000 7.56e-02 1.08e-06
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 1.10e-02 4.66e-02 0.41200 0.210000 0.354000 9.52e-02 5.00e-03
ANTIGEN PROCESSING CROSS PRESENTATION 94 2.44e-10 8.39e-09 0.41200 -0.198000 -0.361000 9.15e-04 1.48e-09
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 1.98e-09 6.09e-08 0.41100 -0.200000 -0.359000 1.27e-03 7.20e-09
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 64 1.61e-08 3.77e-07 0.41100 -0.174000 -0.372000 1.60e-02 2.70e-07
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 70 9.20e-08 1.65e-06 0.41000 -0.198000 -0.359000 4.15e-03 2.13e-07
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 5.46e-03 2.65e-02 0.40600 0.346000 0.212000 2.28e-03 6.11e-02
LGI ADAM INTERACTIONS 14 1.49e-01 3.13e-01 0.40500 0.290000 0.283000 6.01e-02 6.66e-02
DEGRADATION OF DVL 56 3.71e-08 7.49e-07 0.40300 -0.155000 -0.372000 4.47e-02 1.43e-06
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 5.23e-02 1.55e-01 0.40100 -0.250000 -0.314000 5.31e-02 1.52e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.09e-08 2.66e-07 0.40100 -0.173000 -0.362000 1.25e-02 1.67e-07
RHOBTB3 ATPASE CYCLE 10 2.04e-01 3.88e-01 0.39900 -0.236000 -0.322000 1.97e-01 7.75e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 3.04e-02 1.02e-01 0.39900 -0.215000 -0.336000 1.04e-01 1.13e-02
DEGRADATION OF AXIN 54 2.45e-07 4.15e-06 0.39700 -0.159000 -0.364000 4.34e-02 3.78e-06
PHOSPHORYLATION OF THE APC C 17 5.70e-02 1.66e-01 0.39600 -0.224000 -0.327000 1.10e-01 1.95e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 1.89e-08 4.17e-07 0.39500 -0.189000 -0.347000 3.30e-03 6.53e-08
HEDGEHOG LIGAND BIOGENESIS 62 1.20e-08 2.88e-07 0.39300 -0.149000 -0.364000 4.27e-02 7.43e-07
INTERLEUKIN 6 SIGNALING 10 7.21e-02 1.94e-01 0.39200 0.163000 0.357000 3.72e-01 5.09e-02
DEGRADATION OF GLI1 BY THE PROTEASOME 58 3.16e-07 4.99e-06 0.39100 -0.164000 -0.355000 3.06e-02 2.93e-06
CELLULAR RESPONSE TO STARVATION 145 1.47e-26 1.33e-24 0.38800 -0.094300 -0.376000 5.03e-02 5.60e-15
E2F MEDIATED REGULATION OF DNA REPLICATION 19 3.82e-02 1.25e-01 0.38700 -0.325000 -0.211000 1.41e-02 1.12e-01
MET ACTIVATES RAS SIGNALING 10 2.58e-01 4.45e-01 0.38700 -0.301000 -0.244000 9.96e-02 1.82e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 2.02e-01 3.87e-01 0.38600 0.272000 0.274000 8.95e-02 8.72e-02
G1 S DNA DAMAGE CHECKPOINTS 66 7.89e-08 1.44e-06 0.38500 -0.163000 -0.349000 2.20e-02 9.34e-07
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 1.26e-01 2.83e-01 0.38400 0.324000 0.206000 5.19e-02 2.17e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 2.09e-01 3.94e-01 0.38300 0.230000 0.306000 1.87e-01 7.85e-02
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 1.85e-01 3.66e-01 0.38300 0.294000 0.245000 6.63e-02 1.27e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 5.35e-07 8.24e-06 0.38300 -0.197000 -0.328000 2.50e-03 4.66e-07
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 2.82e-04 2.20e-03 0.38200 0.235000 0.301000 1.64e-03 5.44e-05
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 1.52e-01 3.17e-01 0.38200 0.288000 0.250000 5.32e-02 9.33e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 1.12e-04 9.75e-04 0.38100 0.250000 0.287000 2.19e-04 2.19e-05
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 8.10e-06 1.01e-04 0.38000 -0.099300 -0.366000 3.39e-01 4.13e-04
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 3.29e-04 2.47e-03 0.38000 0.369000 0.090100 4.31e-03 4.86e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 9.43e-05 8.53e-04 0.37900 0.107000 0.363000 3.44e-01 1.34e-03
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 2.05e-01 3.90e-01 0.37900 -0.297000 -0.235000 7.53e-02 1.58e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.56e-01 3.24e-01 0.37800 -0.287000 -0.247000 5.47e-02 9.81e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 37 6.99e-03 3.25e-02 0.37700 0.230000 0.299000 1.54e-02 1.68e-03
INFLUENZA INFECTION 145 7.56e-20 4.91e-18 0.37400 -0.125000 -0.353000 9.61e-03 2.16e-13
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 2.81e-03 1.57e-02 0.37400 -0.153000 -0.341000 1.96e-01 3.80e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 1.84e-05 1.99e-04 0.37300 0.097900 0.360000 3.54e-01 6.50e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 5.28e-09 1.44e-07 0.37200 -0.013900 -0.371000 8.90e-01 2.23e-04
CDC42 GTPASE CYCLE 152 4.68e-09 1.33e-07 0.37100 0.231000 0.291000 9.36e-07 6.04e-10
PHASE 2 PLATEAU PHASE 13 2.26e-01 4.13e-01 0.37100 0.270000 0.254000 9.20e-02 1.13e-01
PENTOSE PHOSPHATE PATHWAY 13 1.26e-02 5.13e-02 0.37000 -0.107000 -0.355000 5.06e-01 2.69e-02
CELLULAR RESPONSE TO HYPOXIA 72 7.85e-09 2.00e-07 0.36900 -0.140000 -0.341000 4.03e-02 5.50e-07
REGULATION OF BACH1 ACTIVITY 11 2.18e-01 4.05e-01 0.36600 -0.211000 -0.299000 2.25e-01 8.60e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 8.40e-02 2.17e-01 0.36600 -0.235000 -0.280000 6.20e-02 2.62e-02
DNA REPLICATION PRE INITIATION 80 3.86e-07 6.02e-06 0.36600 -0.177000 -0.320000 6.23e-03 7.36e-07
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 8.41e-09 2.09e-07 0.36600 0.160000 -0.329000 2.27e-01 1.31e-02
PYROPTOSIS 21 4.43e-02 1.36e-01 0.36500 -0.201000 -0.304000 1.11e-01 1.58e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 7.62e-03 3.46e-02 0.36400 -0.159000 -0.327000 1.86e-01 6.58e-03
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 1.25e-02 5.13e-02 0.36300 -0.197000 -0.305000 6.59e-02 4.47e-03
GAP JUNCTION ASSEMBLY 22 1.22e-10 4.61e-09 0.36200 0.293000 -0.213000 1.74e-02 8.40e-02
SYNTHESIS OF PE 13 1.66e-01 3.41e-01 0.36200 0.206000 0.297000 1.97e-01 6.34e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 1.28e-01 2.86e-01 0.36200 0.234000 0.276000 8.51e-02 4.29e-02
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 4.55e-02 1.40e-01 0.36200 0.227000 0.282000 4.51e-02 1.29e-02
INTERLEUKIN 20 FAMILY SIGNALING 13 1.80e-01 3.62e-01 0.36100 0.211000 0.293000 1.87e-01 6.74e-02
PEPTIDE HORMONE METABOLISM 58 1.93e-03 1.16e-02 0.36000 -0.247000 -0.262000 1.13e-03 5.56e-04
PINK1 PRKN MEDIATED MITOPHAGY 22 4.76e-04 3.46e-03 0.35800 -0.088600 -0.347000 4.72e-01 4.87e-03
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 5.73e-07 8.59e-06 0.35800 -0.118000 -0.338000 1.47e-01 2.97e-05
NEPHRIN FAMILY INTERACTIONS 22 1.68e-02 6.41e-02 0.35800 0.168000 0.316000 1.74e-01 1.03e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 5.73e-02 1.66e-01 0.35800 -0.286000 -0.214000 1.75e-02 7.52e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 2.88e-07 4.68e-06 0.35600 -0.130000 -0.331000 8.12e-02 9.07e-06
IRE1ALPHA ACTIVATES CHAPERONES 49 4.93e-03 2.42e-02 0.35600 0.268000 0.234000 1.18e-03 4.60e-03
MITOCHONDRIAL PROTEIN IMPORT 63 8.29e-15 4.41e-13 0.35500 -0.018100 -0.355000 8.04e-01 1.13e-06
HDMS DEMETHYLATE HISTONES 27 5.62e-04 3.91e-03 0.35400 0.115000 0.334000 2.99e-01 2.64e-03
RRNA PROCESSING IN THE MITOCHONDRION 10 2.40e-02 8.50e-02 0.35300 -0.073100 -0.346000 6.89e-01 5.85e-02
AMINE LIGAND BINDING RECEPTORS 29 3.27e-03 1.79e-02 0.35300 0.156000 0.317000 1.47e-01 3.13e-03
CARNITINE METABOLISM 14 2.29e-01 4.15e-01 0.35200 0.263000 0.234000 8.84e-02 1.30e-01
PURINE CATABOLISM 16 1.49e-01 3.13e-01 0.34800 -0.207000 -0.279000 1.52e-01 5.30e-02
CHAPERONE MEDIATED AUTOPHAGY 19 3.27e-04 2.47e-03 0.34700 -0.046000 -0.344000 7.28e-01 9.40e-03
MATURATION OF NUCLEOPROTEIN 10 2.14e-02 7.81e-02 0.34700 -0.342000 -0.061600 6.14e-02 7.36e-01
RHOBTB1 GTPASE CYCLE 23 6.85e-02 1.88e-01 0.34700 -0.277000 -0.208000 2.14e-02 8.40e-02
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 3.83e-02 1.25e-01 0.34700 -0.170000 -0.302000 1.89e-01 1.93e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.82e-01 3.63e-01 0.34600 -0.211000 -0.274000 1.57e-01 6.57e-02
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 1.25e-01 2.83e-01 0.34600 -0.209000 -0.276000 1.25e-01 4.25e-02
DNA REPLICATION 122 6.51e-09 1.69e-07 0.34500 -0.173000 -0.298000 9.72e-04 1.27e-08
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 1.22e-01 2.77e-01 0.34500 -0.213000 -0.271000 1.08e-01 4.06e-02
NEUREXINS AND NEUROLIGINS 54 2.24e-04 1.81e-03 0.34500 0.172000 0.299000 2.84e-02 1.48e-04
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 3.83e-02 1.25e-01 0.34500 0.119000 0.324000 4.59e-01 4.33e-02
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 6.03e-03 2.89e-02 0.34400 -0.121000 -0.322000 3.37e-01 1.07e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 4.16e-02 1.31e-01 0.34300 0.230000 0.255000 2.44e-02 1.26e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 4.82e-02 1.46e-01 0.34300 0.296000 0.173000 2.21e-02 1.81e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.26e-02 5.13e-02 0.34200 0.184000 0.289000 7.17e-02 4.69e-03
RMTS METHYLATE HISTONE ARGININES 43 3.39e-03 1.84e-02 0.34200 0.287000 0.188000 1.15e-03 3.34e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 35 1.38e-04 1.18e-03 0.34200 0.322000 0.114000 9.67e-04 2.43e-01
INSULIN PROCESSING 24 1.56e-02 6.10e-02 0.34100 -0.303000 -0.157000 1.03e-02 1.84e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 1.65e-08 3.78e-07 0.34100 0.322000 -0.112000 7.53e-03 3.53e-01
G ALPHA 12 13 SIGNALLING EVENTS 74 4.87e-04 3.51e-03 0.34000 0.216000 0.263000 1.32e-03 9.40e-05
RHOB GTPASE CYCLE 67 1.06e-04 9.34e-04 0.34000 0.181000 0.288000 1.05e-02 4.64e-05
REGULATION OF BETA CELL DEVELOPMENT 24 1.01e-01 2.46e-01 0.33900 0.234000 0.245000 4.69e-02 3.76e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 1.58e-01 3.27e-01 0.33900 -0.300000 -0.158000 8.50e-02 3.64e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 5.20e-13 2.43e-11 0.33900 -0.039000 -0.337000 5.79e-01 1.58e-06
S PHASE 154 5.31e-08 1.00e-06 0.33700 -0.203000 -0.269000 1.33e-05 8.46e-09
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 1.39e-04 1.18e-03 0.33700 0.228000 0.247000 1.33e-04 3.40e-05
SIGNALING BY ROBO RECEPTORS 206 5.29e-23 3.64e-21 0.33700 -0.110000 -0.318000 6.70e-03 3.66e-15
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 3.92e-01 5.73e-01 0.33500 0.229000 0.245000 2.09e-01 1.81e-01
LONG TERM POTENTIATION 23 1.40e-02 5.61e-02 0.33400 0.142000 0.302000 2.39e-01 1.20e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.11e-02 4.67e-02 0.33400 0.063400 0.328000 6.92e-01 4.07e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 11 1.46e-01 3.09e-01 0.33400 -0.148000 -0.299000 3.95e-01 8.58e-02
REGULATION OF RAS BY GAPS 67 3.34e-06 4.60e-05 0.33400 -0.140000 -0.303000 4.81e-02 1.81e-05
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 2.22e-01 4.09e-01 0.33300 -0.173000 -0.285000 3.20e-01 1.02e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 67 1.11e-05 1.31e-04 0.33200 -0.149000 -0.297000 3.47e-02 2.62e-05
FATTY ACYL COA BIOSYNTHESIS 32 2.89e-02 9.86e-02 0.33100 -0.193000 -0.268000 5.89e-02 8.62e-03
RRNA PROCESSING 194 5.10e-23 3.64e-21 0.33000 -0.095700 -0.316000 2.17e-02 3.20e-14
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 3.71e-01 5.54e-01 0.32900 -0.239000 -0.226000 1.69e-01 1.94e-01
LAMININ INTERACTIONS 28 7.03e-02 1.91e-01 0.32800 0.211000 0.251000 5.29e-02 2.13e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 1.03e-02 4.41e-02 0.32800 0.240000 0.223000 2.98e-03 5.88e-03
CITRIC ACID CYCLE TCA CYCLE 22 4.63e-05 4.59e-04 0.32700 -0.010000 -0.327000 9.35e-01 7.91e-03
SHC MEDIATED CASCADE FGFR4 11 3.80e-01 5.64e-01 0.32600 -0.233000 -0.228000 1.81e-01 1.90e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 1.59e-06 2.32e-05 0.32600 -0.149000 -0.290000 1.82e-02 4.44e-06
ANCHORING FIBRIL FORMATION 14 2.62e-01 4.49e-01 0.32500 0.253000 0.204000 1.02e-01 1.87e-01
PEXOPHAGY 11 8.23e-02 2.15e-01 0.32400 0.305000 0.109000 7.95e-02 5.32e-01
TRP CHANNELS 18 1.41e-01 3.02e-01 0.32300 0.186000 0.265000 1.72e-01 5.21e-02
FCERI MEDIATED NF KB ACTIVATION 77 1.74e-05 1.92e-04 0.32300 -0.157000 -0.282000 1.70e-02 1.87e-05
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 4.21e-01 5.98e-01 0.32300 -0.223000 -0.234000 2.23e-01 2.01e-01
INTEGRIN SIGNALING 24 8.61e-02 2.20e-01 0.32300 0.192000 0.259000 1.03e-01 2.80e-02
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 20 1.36e-01 2.97e-01 0.32200 -0.194000 -0.257000 1.32e-01 4.69e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 1.09e-01 2.58e-01 0.32100 0.231000 0.223000 4.16e-02 4.87e-02
RHOBTB2 GTPASE CYCLE 23 1.26e-01 2.83e-01 0.32100 -0.207000 -0.245000 8.59e-02 4.21e-02
INTERLEUKIN 6 FAMILY SIGNALING 19 6.87e-02 1.88e-01 0.32100 0.156000 0.280000 2.40e-01 3.45e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 3.44e-02 1.14e-01 0.32000 -0.174000 -0.268000 1.05e-01 1.25e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 5.18e-02 1.54e-01 0.31900 -0.103000 -0.302000 5.20e-01 5.95e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 7.62e-02 2.04e-01 0.31800 -0.157000 -0.277000 2.36e-01 3.69e-02
INSULIN RECEPTOR RECYCLING 20 4.18e-03 2.13e-02 0.31700 -0.078200 -0.307000 5.45e-01 1.73e-02
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 2.81e-06 3.91e-05 0.31600 -0.144000 -0.281000 2.19e-02 7.42e-06
KINESINS 48 2.00e-03 1.20e-02 0.31500 0.273000 0.158000 1.08e-03 5.77e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 6.06e-02 1.72e-01 0.31500 0.121000 0.291000 4.16e-01 5.09e-02
COLLAGEN DEGRADATION 51 7.58e-03 3.45e-02 0.31400 0.189000 0.251000 1.99e-02 1.90e-03
ECM PROTEOGLYCANS 66 4.42e-03 2.23e-02 0.31400 0.214000 0.230000 2.65e-03 1.24e-03
RET SIGNALING 36 2.72e-02 9.35e-02 0.31400 0.183000 0.255000 5.73e-02 8.08e-03
INOSITOL PHOSPHATE METABOLISM 47 9.59e-03 4.15e-02 0.31300 0.184000 0.254000 2.95e-02 2.60e-03
REGULATED NECROSIS 46 4.72e-03 2.36e-02 0.31300 -0.166000 -0.265000 5.08e-02 1.85e-03
RAB GERANYLGERANYLATION 59 7.86e-03 3.54e-02 0.31300 -0.210000 -0.231000 5.22e-03 2.12e-03
O LINKED GLYCOSYLATION 87 3.35e-04 2.50e-03 0.31100 0.189000 0.247000 2.33e-03 6.75e-05
TIE2 SIGNALING 17 2.56e-01 4.45e-01 0.31100 -0.225000 -0.215000 1.09e-01 1.25e-01
OLFACTORY SIGNALING PATHWAY 30 9.10e-02 2.30e-01 0.30900 -0.210000 -0.227000 4.66e-02 3.15e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX 106 2.21e-04 1.79e-03 0.30900 0.210000 0.227000 1.95e-04 5.52e-05
PRE NOTCH EXPRESSION AND PROCESSING 64 4.86e-03 2.40e-02 0.30800 0.199000 0.236000 5.99e-03 1.11e-03
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.12e-05 1.31e-04 0.30800 0.146000 0.271000 2.00e-02 1.61e-05
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 3.70e-01 5.53e-01 0.30700 -0.198000 -0.235000 2.34e-01 1.59e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.68e-02 6.41e-02 0.30700 0.303000 0.048000 5.84e-02 7.65e-01
G PROTEIN ACTIVATION 22 9.27e-02 2.31e-01 0.30700 -0.166000 -0.258000 1.77e-01 3.63e-02
ABC TRANSPORTER DISORDERS 69 1.61e-06 2.33e-05 0.30700 -0.108000 -0.287000 1.20e-01 3.75e-05
METABOLISM OF AMINO ACIDS AND DERIVATIVES 314 8.99e-32 1.17e-29 0.30500 -0.087000 -0.293000 8.17e-03 5.00e-19
RETROGRADE NEUROTROPHIN SIGNALLING 13 6.01e-02 1.71e-01 0.30500 0.290000 0.093700 7.04e-02 5.59e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 1.82e-01 3.63e-01 0.30500 0.223000 0.207000 7.00e-02 9.25e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 4.70e-02 1.43e-01 0.30400 -0.215000 -0.215000 1.85e-02 1.85e-02
BIOTIN TRANSPORT AND METABOLISM 11 3.87e-01 5.70e-01 0.30400 0.240000 0.187000 1.69e-01 2.82e-01
G2 M CHECKPOINTS 135 5.69e-07 8.59e-06 0.30400 -0.163000 -0.256000 1.05e-03 2.87e-07
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 4.28e-01 6.07e-01 0.30300 0.224000 0.204000 1.99e-01 2.43e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 3.20e-04 2.43e-03 0.30100 -0.063400 -0.294000 5.48e-01 5.28e-03
PLATELET ADHESION TO EXPOSED COLLAGEN 11 2.73e-01 4.62e-01 0.30100 -0.151000 -0.260000 3.86e-01 1.35e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.37e-02 1.12e-01 0.29900 0.277000 0.114000 3.23e-02 3.76e-01
MTORC1 MEDIATED SIGNALLING 24 8.13e-02 2.13e-01 0.29900 -0.160000 -0.252000 1.74e-01 3.23e-02
ENOS ACTIVATION 11 1.72e-01 3.50e-01 0.29900 -0.119000 -0.274000 4.93e-01 1.16e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 2.02e-02 7.49e-02 0.29800 -0.285000 -0.086200 3.63e-02 5.27e-01
METABOLISM OF COFACTORS 18 6.26e-02 1.77e-01 0.29700 -0.122000 -0.271000 3.71e-01 4.64e-02
REGULATION OF IFNG SIGNALING 13 3.57e-01 5.45e-01 0.29700 -0.230000 -0.188000 1.51e-01 2.41e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 2.97e-01 4.83e-01 0.29700 0.232000 0.185000 1.19e-01 2.16e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 4.01e-09 1.17e-07 0.29600 -0.077300 -0.286000 2.21e-01 5.84e-06
RAS PROCESSING 24 2.36e-03 1.35e-02 0.29600 -0.066200 -0.289000 5.75e-01 1.44e-02
PKMTS METHYLATE HISTONE LYSINES 48 1.89e-04 1.55e-03 0.29600 0.105000 0.276000 2.08e-01 9.22e-04
GAP JUNCTION TRAFFICKING AND REGULATION 34 1.41e-10 5.16e-09 0.29500 0.254000 -0.151000 1.05e-02 1.27e-01
RHO GTPASES ACTIVATE IQGAPS 23 2.68e-05 2.76e-04 0.29500 0.293000 -0.032500 1.49e-02 7.88e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.21e-02 7.98e-02 0.29500 0.159000 0.248000 9.01e-02 8.17e-03
EFFECTS OF PIP2 HYDROLYSIS 27 8.27e-02 2.15e-01 0.29400 0.166000 0.242000 1.36e-01 2.93e-02
SUMOYLATION OF DNA METHYLATION PROTEINS 16 2.41e-01 4.27e-01 0.29300 0.168000 0.239000 2.43e-01 9.76e-02
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 2.77e-01 4.64e-01 0.29300 0.200000 0.214000 1.42e-01 1.17e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 3.07e-05 3.09e-04 0.29100 0.088100 0.277000 2.72e-01 5.39e-04
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 4.12e-02 1.31e-01 0.29000 0.272000 0.100000 4.54e-02 4.62e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 2.02e-01 3.87e-01 0.28900 0.256000 0.134000 1.10e-01 4.03e-01
DARPP 32 EVENTS 23 1.74e-01 3.53e-01 0.28900 -0.225000 -0.181000 6.15e-02 1.34e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.05e-01 2.55e-01 0.28800 0.270000 0.099800 9.23e-02 5.33e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 9.27e-02 2.31e-01 0.28700 0.173000 0.229000 1.00e-01 3.00e-02
IRON UPTAKE AND TRANSPORT 51 7.16e-04 4.87e-03 0.28600 -0.118000 -0.261000 1.46e-01 1.26e-03
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 85 1.06e-04 9.34e-04 0.28500 0.141000 0.248000 2.42e-02 7.98e-05
VOLTAGE GATED POTASSIUM CHANNELS 40 1.08e-02 4.61e-02 0.28400 0.136000 0.249000 1.36e-01 6.35e-03
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 3.60e-01 5.46e-01 0.28300 0.221000 0.178000 1.53e-01 2.49e-01
SIGNALING BY THE B CELL RECEPTOR BCR 104 9.48e-05 8.53e-04 0.28300 -0.156000 -0.236000 6.16e-03 3.22e-05
SEPARATION OF SISTER CHROMATIDS 165 3.90e-08 7.74e-07 0.28200 -0.141000 -0.244000 1.73e-03 6.26e-08
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.20e-03 7.73e-03 0.28200 -0.047600 -0.278000 6.75e-01 1.41e-02
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 37 3.61e-03 1.92e-02 0.28200 -0.107000 -0.261000 2.61e-01 5.99e-03
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 2.95e-01 4.83e-01 0.28100 0.126000 0.251000 4.91e-01 1.69e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 3.69e-01 5.53e-01 0.28000 0.187000 0.208000 2.11e-01 1.62e-01
DNA DAMAGE BYPASS 46 5.13e-02 1.53e-01 0.28000 -0.199000 -0.196000 1.93e-02 2.13e-02
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 8.52e-02 2.19e-01 0.27900 -0.159000 -0.229000 1.32e-01 2.98e-02
DISEASES OF GLYCOSYLATION 126 1.06e-04 9.34e-04 0.27900 0.220000 0.171000 1.97e-05 9.29e-04
RECYCLING PATHWAY OF L1 40 7.29e-05 6.99e-04 0.27800 0.273000 0.053800 2.82e-03 5.56e-01
CELL CYCLE CHECKPOINTS 243 2.38e-08 4.98e-07 0.27800 -0.170000 -0.220000 5.26e-06 3.46e-09
MITOTIC G1 PHASE AND G1 S TRANSITION 141 6.43e-06 8.27e-05 0.27800 -0.154000 -0.231000 1.59e-03 2.16e-06
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 3.14e-02 1.05e-01 0.27800 0.176000 0.215000 3.16e-02 8.51e-03
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 6.57e-02 1.83e-01 0.27800 0.258000 0.103000 5.80e-02 4.50e-01
EXTRACELLULAR MATRIX ORGANIZATION 240 2.76e-07 4.55e-06 0.27800 0.195000 0.198000 2.15e-07 1.29e-07
THE PHOTOTRANSDUCTION CASCADE 21 1.83e-01 3.63e-01 0.27800 -0.228000 -0.159000 7.07e-02 2.08e-01
PLATELET AGGREGATION PLUG FORMATION 32 1.30e-01 2.90e-01 0.27800 0.200000 0.193000 5.04e-02 5.93e-02
RHOBTB GTPASE CYCLE 35 1.01e-01 2.46e-01 0.27700 -0.208000 -0.183000 3.35e-02 6.12e-02
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.96e-01 4.83e-01 0.27600 0.212000 0.177000 1.19e-01 1.95e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 2.84e-02 9.72e-02 0.27600 0.089700 0.261000 4.77e-01 3.83e-02
DEATH RECEPTOR SIGNALLING 133 8.50e-05 7.83e-04 0.27600 0.170000 0.217000 7.43e-04 1.54e-05
GP1B IX V ACTIVATION SIGNALLING 10 5.23e-01 6.82e-01 0.27500 0.182000 0.207000 3.20e-01 2.58e-01
PI METABOLISM 79 1.74e-05 1.92e-04 0.27500 0.108000 0.253000 9.83e-02 1.02e-04
CALNEXIN CALRETICULIN CYCLE 26 8.55e-02 2.19e-01 0.27500 -0.141000 -0.236000 2.12e-01 3.76e-02
FORMATION OF APOPTOSOME 10 3.99e-01 5.80e-01 0.27500 -0.144000 -0.234000 4.31e-01 2.00e-01
G2 M DNA DAMAGE CHECKPOINT 65 1.62e-02 6.28e-02 0.27400 -0.182000 -0.204000 1.12e-02 4.42e-03
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 2.69e-01 4.57e-01 0.27300 0.231000 0.146000 1.22e-01 3.28e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 2.58e-02 8.98e-02 0.27200 -0.130000 -0.239000 1.83e-01 1.43e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 2.06e-01 3.90e-01 0.27200 -0.149000 -0.227000 2.61e-01 8.63e-02
SCAVENGING BY CLASS A RECEPTORS 13 8.00e-03 3.57e-02 0.27000 0.023500 -0.269000 8.83e-01 9.29e-02
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 26 2.03e-01 3.87e-01 0.27000 0.182000 0.200000 1.09e-01 7.80e-02
RIPK1 MEDIATED REGULATED NECROSIS 25 9.83e-02 2.41e-01 0.27000 -0.137000 -0.232000 2.36e-01 4.45e-02
BUDDING AND MATURATION OF HIV VIRION 27 3.79e-04 2.81e-03 0.26900 -0.015900 -0.269000 8.86e-01 1.57e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 1.32e-05 1.53e-04 0.26900 -0.103000 -0.248000 1.05e-01 9.40e-05
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 2.99e-01 4.84e-01 0.26800 0.121000 0.239000 4.85e-01 1.69e-01
SIGNALING BY NOTCH2 33 1.41e-01 3.01e-01 0.26800 0.191000 0.188000 5.74e-02 6.13e-02
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 1.06e-01 2.56e-01 0.26800 -0.148000 -0.224000 1.75e-01 4.07e-02
RAC1 GTPASE CYCLE 176 2.52e-07 4.21e-06 0.26800 0.141000 0.228000 1.31e-03 1.83e-07
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.31e-01 4.19e-01 0.26800 -0.206000 -0.171000 8.71e-02 1.57e-01
ASPARTATE AND ASPARAGINE METABOLISM 10 5.55e-01 7.08e-01 0.26700 -0.185000 -0.192000 3.12e-01 2.93e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 1.33e-01 2.92e-01 0.26500 -0.177000 -0.197000 7.43e-02 4.66e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 8.30e-02 2.16e-01 0.26400 -0.235000 -0.122000 4.67e-02 3.01e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 4.00e-01 5.80e-01 0.26300 0.186000 0.187000 1.99e-01 1.95e-01
GLUCONEOGENESIS 27 2.19e-06 3.09e-05 0.26300 0.244000 -0.098600 2.84e-02 3.75e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 1.42e-02 5.65e-02 0.26200 0.049900 0.257000 6.99e-01 4.63e-02
CELLULAR RESPONSE TO CHEMICAL STRESS 150 1.51e-12 6.81e-11 0.26100 -0.066400 -0.253000 1.61e-01 9.23e-08
CLEC7A DECTIN 1 SIGNALING 95 2.50e-04 1.98e-03 0.26100 -0.132000 -0.225000 2.60e-02 1.49e-04
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.43e-03 9.09e-03 0.26100 0.118000 -0.233000 4.60e-01 1.46e-01
KERATAN SULFATE BIOSYNTHESIS 23 8.61e-02 2.20e-01 0.26100 0.234000 0.116000 5.25e-02 3.37e-01
SIGNALLING TO RAS 18 2.38e-01 4.27e-01 0.26100 0.220000 0.139000 1.06e-01 3.06e-01
PROTEIN LOCALIZATION 156 5.50e-14 2.68e-12 0.26100 -0.057200 -0.254000 2.18e-01 4.35e-08
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 2.56e-01 4.45e-01 0.25800 0.199000 0.165000 9.90e-02 1.71e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 4.43e-04 3.26e-03 0.25800 -0.158000 -0.204000 2.37e-03 8.82e-05
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 3.82e-01 5.66e-01 0.25800 -0.121000 -0.228000 5.08e-01 2.13e-01
HSF1 ACTIVATION 25 1.64e-04 1.38e-03 0.25700 0.028800 -0.256000 8.03e-01 2.69e-02
HSF1 DEPENDENT TRANSACTIVATION 33 5.99e-04 4.12e-03 0.25600 0.254000 0.036900 1.16e-02 7.13e-01
VLDLR INTERNALISATION AND DEGRADATION 12 9.13e-02 2.30e-01 0.25500 0.250000 0.049700 1.34e-01 7.65e-01
C TYPE LECTIN RECEPTORS CLRS 113 1.89e-04 1.55e-03 0.25500 -0.136000 -0.215000 1.23e-02 7.74e-05
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 2.40e-04 1.93e-03 0.25400 0.005560 -0.254000 9.59e-01 2.00e-02
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 5.52e-01 7.06e-01 0.25400 0.172000 0.186000 3.22e-01 2.84e-01
MET ACTIVATES PTK2 SIGNALING 29 2.10e-01 3.94e-01 0.25400 0.172000 0.186000 1.08e-01 8.26e-02
FRS MEDIATED FGFR4 SIGNALING 13 4.98e-01 6.62e-01 0.25400 -0.185000 -0.173000 2.48e-01 2.79e-01
INTERLEUKIN 10 SIGNALING 20 2.55e-01 4.44e-01 0.25400 -0.209000 -0.144000 1.06e-01 2.65e-01
MITOPHAGY 29 3.68e-03 1.94e-02 0.25300 -0.051200 -0.248000 6.33e-01 2.09e-02
SIGNALING BY NOTCH1 75 4.69e-03 2.36e-02 0.25300 0.139000 0.211000 3.75e-02 1.57e-03
PI 3K CASCADE FGFR4 11 3.86e-01 5.70e-01 0.25300 -0.220000 -0.124000 2.06e-01 4.77e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 2.41e-01 4.27e-01 0.25300 0.105000 0.230000 5.12e-01 1.51e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 32 1.76e-01 3.55e-01 0.25200 -0.189000 -0.167000 6.40e-02 1.02e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 9.79e-02 2.40e-01 0.25200 -0.103000 -0.230000 4.14e-01 6.83e-02
RHOC GTPASE CYCLE 73 3.83e-03 1.99e-02 0.25100 0.132000 0.214000 5.11e-02 1.58e-03
APOPTOTIC FACTOR MEDIATED RESPONSE 18 7.92e-02 2.08e-01 0.25100 -0.081400 -0.238000 5.50e-01 8.08e-02
ER QUALITY CONTROL COMPARTMENT ERQC 21 2.85e-01 4.73e-01 0.25100 -0.153000 -0.199000 2.25e-01 1.14e-01
SIGNALING BY BMP 24 2.55e-02 8.90e-02 0.25100 -0.240000 -0.073000 4.20e-02 5.36e-01
CHROMATIN MODIFYING ENZYMES 218 1.49e-07 2.56e-06 0.25000 0.135000 0.211000 6.30e-04 8.20e-08
TCR SIGNALING 101 1.01e-03 6.82e-03 0.25000 -0.139000 -0.208000 1.60e-02 3.16e-04
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 1.70e-01 3.48e-01 0.25000 -0.200000 -0.149000 6.19e-02 1.65e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 1.82e-03 1.11e-02 0.25000 -0.040700 0.246000 7.65e-01 7.05e-02
HOST INTERACTIONS OF HIV FACTORS 124 7.81e-05 7.43e-04 0.24900 -0.129000 -0.213000 1.29e-02 4.22e-05
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 2.96e-01 4.83e-01 0.24900 0.165000 0.186000 1.70e-01 1.22e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 8.99e-02 2.28e-01 0.24900 -0.042600 -0.246000 7.98e-01 1.41e-01
MITOTIC SPINDLE CHECKPOINT 96 7.53e-03 3.44e-02 0.24900 -0.178000 -0.174000 2.66e-03 3.18e-03
TRAF6 MEDIATED IRF7 ACTIVATION 15 1.07e-02 4.57e-02 0.24800 -0.015200 0.248000 9.19e-01 9.64e-02
LATE ENDOSOMAL MICROAUTOPHAGY 30 9.19e-06 1.11e-04 0.24800 0.064700 -0.239000 5.40e-01 2.32e-02
KILLING MECHANISMS 10 5.79e-01 7.24e-01 0.24800 0.158000 0.191000 3.86e-01 2.96e-01
MITOTIC METAPHASE AND ANAPHASE 206 8.92e-07 1.32e-05 0.24700 -0.136000 -0.206000 7.87e-04 3.45e-07
NETRIN 1 SIGNALING 48 1.66e-02 6.41e-02 0.24400 0.115000 0.215000 1.66e-01 9.87e-03
SIGNALING BY NOTCH3 48 9.18e-02 2.30e-01 0.24400 0.166000 0.179000 4.69e-02 3.18e-02
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 4.80e-01 6.54e-01 0.24400 -0.141000 -0.199000 3.96e-01 2.33e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 7.97e-05 7.52e-04 0.24400 -0.067400 -0.234000 3.55e-01 1.30e-03
CHONDROITIN SULFATE BIOSYNTHESIS 19 2.22e-01 4.09e-01 0.24400 0.212000 0.121000 1.10e-01 3.63e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 1.31e-01 2.91e-01 0.24400 -0.151000 -0.191000 1.13e-01 4.41e-02
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 2.25e-01 4.12e-01 0.24400 -0.136000 -0.202000 2.59e-01 9.34e-02
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 3.83e-01 5.67e-01 0.24300 0.120000 0.212000 4.73e-01 2.04e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 2.52e-03 1.43e-02 0.24300 0.181000 0.162000 6.04e-04 2.24e-03
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 1.98e-01 3.82e-01 0.24300 -0.083500 -0.228000 6.02e-01 1.55e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 15 4.82e-01 6.54e-01 0.24200 0.176000 0.166000 2.38e-01 2.66e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 3.23e-01 5.09e-01 0.24100 0.189000 0.149000 1.33e-01 2.36e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 8.83e-02 2.24e-01 0.24000 -0.097800 -0.219000 4.07e-01 6.30e-02
MEIOTIC RECOMBINATION 38 8.76e-02 2.23e-01 0.24000 -0.132000 -0.200000 1.59e-01 3.29e-02
ELASTIC FIBRE FORMATION 36 7.78e-02 2.07e-01 0.23900 0.205000 0.124000 3.36e-02 1.98e-01
P75NTR SIGNALS VIA NF KB 16 9.88e-02 2.41e-01 0.23900 0.230000 0.065700 1.12e-01 6.49e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 3.38e-01 5.25e-01 0.23900 0.168000 0.170000 1.64e-01 1.58e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.69e-02 1.43e-01 0.23900 0.000645 -0.239000 9.97e-01 1.52e-01
HIV TRANSCRIPTION INITIATION 45 1.21e-01 2.75e-01 0.23900 -0.168000 -0.170000 5.15e-02 4.90e-02
SIGNALING BY ERBB2 ECD MUTANTS 16 4.49e-01 6.27e-01 0.23800 -0.183000 -0.153000 2.06e-01 2.88e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 111 2.46e-05 2.54e-04 0.23800 -0.099800 -0.216000 6.94e-02 8.33e-05
CYTOPROTECTION BY HMOX1 120 3.59e-08 7.36e-07 0.23800 -0.065200 -0.229000 2.17e-01 1.53e-05
PROGRAMMED CELL DEATH 187 9.31e-08 1.65e-06 0.23700 -0.106000 -0.212000 1.26e-02 5.79e-07
AGGREPHAGY 34 4.89e-06 6.43e-05 0.23700 0.228000 -0.066300 2.17e-02 5.04e-01
STIMULI SENSING CHANNELS 74 8.89e-03 3.91e-02 0.23700 0.129000 0.199000 5.56e-02 3.14e-03
PHOSPHOLIPID METABOLISM 185 2.86e-05 2.90e-04 0.23600 0.137000 0.192000 1.33e-03 6.62e-06
GABA RECEPTOR ACTIVATION 53 8.69e-02 2.21e-01 0.23600 -0.170000 -0.163000 3.19e-02 3.97e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 6.65e-05 6.43e-04 0.23600 -0.091300 -0.218000 1.28e-01 2.89e-04
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 5.05e-02 1.52e-01 0.23600 0.196000 0.131000 1.77e-02 1.12e-01
DEADENYLATION OF MRNA 25 5.70e-02 1.66e-01 0.23600 -0.221000 -0.083000 5.63e-02 4.73e-01
METABOLISM OF STEROID HORMONES 20 2.10e-02 7.70e-02 0.23500 -0.030900 -0.233000 8.11e-01 7.17e-02
O LINKED GLYCOSYLATION OF MUCINS 40 2.65e-02 9.16e-02 0.23300 0.098700 0.211000 2.80e-01 2.08e-02
SEMA4D IN SEMAPHORIN SIGNALING 24 6.89e-02 1.88e-01 0.23300 0.218000 0.082100 6.48e-02 4.87e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 1.47e-01 3.11e-01 0.23300 -0.220000 -0.076000 1.28e-01 5.99e-01
INITIAL TRIGGERING OF COMPLEMENT 11 3.58e-01 5.46e-01 0.23200 0.211000 0.095200 2.25e-01 5.85e-01
DAG AND IP3 SIGNALING 40 1.24e-02 5.13e-02 0.23100 0.081400 0.216000 3.73e-01 1.81e-02
GAB1 SIGNALOSOME 13 5.65e-01 7.17e-01 0.23000 0.166000 0.160000 3.01e-01 3.19e-01
KERATAN SULFATE KERATIN METABOLISM 29 5.44e-02 1.60e-01 0.23000 0.213000 0.087800 4.74e-02 4.13e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 2.79e-01 4.65e-01 0.23000 0.132000 0.189000 2.75e-01 1.17e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 2.61e-01 4.49e-01 0.23000 0.149000 0.176000 1.66e-01 1.02e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 1.57e-03 9.87e-03 0.22900 0.019600 0.229000 8.48e-01 2.53e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 1.08e-01 2.58e-01 0.22900 -0.045500 -0.224000 7.68e-01 1.47e-01
ERBB2 ACTIVATES PTK6 SIGNALING 10 2.79e-01 4.65e-01 0.22800 0.065600 0.218000 7.20e-01 2.32e-01
PHASE II CONJUGATION OF COMPOUNDS 61 7.54e-03 3.44e-02 0.22800 -0.102000 -0.204000 1.68e-01 5.94e-03
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 1.66e-01 3.41e-01 0.22800 0.190000 0.125000 6.71e-02 2.27e-01
CGMP EFFECTS 15 3.58e-02 1.18e-01 0.22700 -0.227000 -0.004820 1.28e-01 9.74e-01
TNFR2 NON CANONICAL NF KB PATHWAY 83 8.50e-06 1.05e-04 0.22700 -0.055300 -0.220000 3.84e-01 5.30e-04
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 2.22e-02 8.00e-02 0.22700 -0.043500 -0.222000 7.12e-01 5.93e-02
RHOA GTPASE CYCLE 141 5.24e-04 3.72e-03 0.22600 0.128000 0.186000 8.64e-03 1.44e-04
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 5.38e-02 1.58e-01 0.22500 0.193000 0.116000 2.34e-02 1.74e-01
APOPTOSIS 165 1.71e-06 2.43e-05 0.22500 -0.098500 -0.203000 2.92e-02 7.31e-06
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.88e-01 3.71e-01 0.22500 0.143000 0.174000 1.32e-01 6.77e-02
GAP JUNCTION DEGRADATION 11 2.10e-02 7.70e-02 0.22400 0.084300 -0.208000 6.28e-01 2.33e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 3.61e-01 5.46e-01 0.22400 0.131000 0.182000 3.11e-01 1.59e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.40e-01 4.27e-01 0.22400 -0.207000 -0.085000 1.66e-01 5.69e-01
SYNTHESIS OF PA 29 2.79e-01 4.65e-01 0.22300 0.171000 0.142000 1.10e-01 1.85e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 25 1.36e-01 2.97e-01 0.22200 -0.200000 -0.096500 8.31e-02 4.04e-01
INTRA GOLGI TRAFFIC 43 2.99e-02 1.01e-01 0.22200 0.094400 0.201000 2.84e-01 2.27e-02
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 4.19e-01 5.98e-01 0.22200 -0.188000 -0.118000 2.09e-01 4.28e-01
DSCAM INTERACTIONS 10 6.05e-01 7.48e-01 0.22100 0.129000 0.180000 4.81e-01 3.24e-01
APOPTOTIC EXECUTION PHASE 45 1.40e-01 3.01e-01 0.22100 -0.171000 -0.140000 4.72e-02 1.05e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 11 4.62e-01 6.38e-01 0.22000 -0.195000 -0.103000 2.64e-01 5.52e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.13e-01 2.63e-01 0.22000 0.070300 0.208000 5.86e-01 1.07e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 1.09e-02 4.64e-02 0.21900 0.181000 -0.124000 2.79e-01 4.58e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 2.74e-01 4.62e-01 0.21900 0.063200 0.210000 7.17e-01 2.29e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 1.10e-01 2.59e-01 0.21800 0.150000 0.158000 5.16e-02 4.08e-02
FRS MEDIATED FGFR2 SIGNALING 18 4.93e-01 6.60e-01 0.21700 -0.150000 -0.158000 2.72e-01 2.47e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 9.77e-02 2.40e-01 0.21700 -0.082400 -0.201000 4.67e-01 7.67e-02
PHASE 0 RAPID DEPOLARISATION 29 9.41e-02 2.33e-01 0.21700 0.089000 0.198000 4.07e-01 6.56e-02
CYTOSOLIC TRNA AMINOACYLATION 24 1.16e-02 4.81e-02 0.21600 -0.014400 -0.216000 9.03e-01 6.72e-02
FGFR2 LIGAND BINDING AND ACTIVATION 11 6.28e-01 7.60e-01 0.21600 -0.136000 -0.168000 4.35e-01 3.35e-01
GLYCOGEN STORAGE DISEASES 12 1.49e-02 5.88e-02 0.21600 0.104000 -0.189000 5.34e-01 2.56e-01
LAGGING STRAND SYNTHESIS 20 2.40e-01 4.27e-01 0.21500 -0.096700 -0.192000 4.54e-01 1.37e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 4.26e-02 1.33e-01 0.21500 -0.130000 -0.172000 5.91e-02 1.24e-02
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 2.59e-01 4.47e-01 0.21500 -0.062600 -0.206000 7.08e-01 2.17e-01
SIGNALING BY PDGFR IN DISEASE 20 3.85e-02 1.25e-01 0.21400 -0.212000 -0.026800 1.00e-01 8.36e-01
GLUCAGON TYPE LIGAND RECEPTORS 25 1.07e-01 2.56e-01 0.21400 -0.079400 -0.199000 4.92e-01 8.57e-02
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 5.97e-02 1.71e-01 0.21400 0.122000 0.175000 1.04e-01 1.99e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.14e-02 7.81e-02 0.21400 -0.110000 0.183000 5.28e-01 2.93e-01
MAPK6 MAPK4 SIGNALING 84 2.23e-03 1.29e-02 0.21300 -0.092300 -0.191000 1.44e-01 2.43e-03
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 6.28e-01 7.60e-01 0.21200 0.173000 0.122000 3.43e-01 5.03e-01
P75NTR REGULATES AXONOGENESIS 10 1.15e-01 2.68e-01 0.21200 0.010700 -0.211000 9.53e-01 2.47e-01
HDACS DEACETYLATE HISTONES 46 4.34e-02 1.34e-01 0.21100 0.188000 0.095000 2.72e-02 2.65e-01
HYALURONAN METABOLISM 15 3.29e-01 5.17e-01 0.21100 0.191000 0.089400 2.01e-01 5.49e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 1.19e-01 2.74e-01 0.21000 -0.078900 -0.195000 4.95e-01 9.20e-02
GLYCOGEN METABOLISM 25 4.13e-02 1.31e-01 0.21000 -0.046200 -0.205000 6.89e-01 7.66e-02
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 30 7.77e-03 3.51e-02 0.20900 0.021500 0.208000 8.38e-01 4.89e-02
REGULATED PROTEOLYSIS OF P75NTR 12 5.02e-01 6.66e-01 0.20900 0.104000 0.181000 5.32e-01 2.78e-01
PI 3K CASCADE FGFR2 16 4.94e-01 6.60e-01 0.20900 -0.169000 -0.122000 2.41e-01 3.99e-01
SHC1 EVENTS IN EGFR SIGNALING 10 5.88e-01 7.34e-01 0.20800 -0.109000 -0.178000 5.51e-01 3.31e-01
G PROTEIN BETA GAMMA SIGNALLING 30 3.14e-01 5.00e-01 0.20800 -0.132000 -0.161000 2.09e-01 1.28e-01
MRNA SPLICING 188 7.52e-06 9.46e-05 0.20800 -0.096700 -0.184000 2.23e-02 1.38e-05
HIV INFECTION 220 2.41e-05 2.52e-04 0.20800 -0.114000 -0.174000 3.69e-03 8.86e-06
ASSEMBLY OF THE HIV VIRION 16 4.14e-03 2.13e-02 0.20700 0.128000 -0.163000 3.77e-01 2.58e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 5.47e-01 7.02e-01 0.20700 0.098600 0.182000 5.89e-01 3.20e-01
SMOOTH MUSCLE CONTRACTION 33 2.46e-03 1.41e-02 0.20700 -0.005310 -0.206000 9.58e-01 4.01e-02
DCC MEDIATED ATTRACTIVE SIGNALING 14 1.97e-01 3.81e-01 0.20700 0.050900 0.200000 7.42e-01 1.95e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 2.48e-01 4.37e-01 0.20500 -0.094100 -0.183000 4.45e-01 1.38e-01
METABOLISM OF RNA 644 3.00e-19 1.85e-17 0.20500 -0.088600 -0.185000 1.33e-04 1.37e-15
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 1.33e-01 2.92e-01 0.20500 -0.131000 -0.158000 9.61e-02 4.47e-02
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 2.44e-02 8.54e-02 0.20500 0.149000 0.140000 7.76e-03 1.21e-02
SHC MEDIATED CASCADE FGFR1 14 6.13e-01 7.54e-01 0.20500 -0.150000 -0.139000 3.32e-01 3.67e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 4.10e-01 5.92e-01 0.20400 0.126000 0.161000 2.95e-01 1.82e-01
SIGNALING BY NOTCH4 83 3.20e-04 2.43e-03 0.20400 -0.062900 -0.194000 3.22e-01 2.21e-03
INTERFERON ALPHA BETA SIGNALING 52 2.80e-03 1.57e-02 0.20400 -0.198000 -0.050600 1.36e-02 5.28e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 4.19e-02 1.32e-01 0.20400 0.121000 0.165000 6.68e-02 1.26e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 40 2.41e-01 4.27e-01 0.20400 0.153000 0.134000 9.34e-02 1.43e-01
SIGNALING BY FGFR2 IN DISEASE 36 1.25e-01 2.83e-01 0.20300 -0.097700 -0.178000 3.11e-01 6.42e-02
OTHER SEMAPHORIN INTERACTIONS 19 4.48e-01 6.27e-01 0.20200 0.117000 0.165000 3.77e-01 2.13e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 31 9.87e-02 2.41e-01 0.20200 0.186000 0.079500 7.35e-02 4.44e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 2.94e-01 4.83e-01 0.20200 0.178000 0.095300 1.59e-01 4.50e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 2.98e-01 4.84e-01 0.20200 -0.140000 -0.145000 1.45e-01 1.33e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.83e-02 6.84e-02 0.20200 0.194000 0.055600 3.63e-02 5.48e-01
MISMATCH REPAIR 14 5.71e-01 7.20e-01 0.20100 -0.119000 -0.162000 4.41e-01 2.94e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.44e-05 1.63e-04 0.20100 0.037000 -0.197000 6.58e-01 1.81e-02
SIGNALING BY KIT IN DISEASE 20 2.54e-01 4.44e-01 0.20100 -0.182000 -0.083800 1.58e-01 5.17e-01
DISEASES OF METABOLISM 200 5.48e-06 7.12e-05 0.20000 0.179000 0.090800 1.35e-05 2.70e-02
TBC RABGAPS 43 2.03e-01 3.87e-01 0.20000 0.157000 0.124000 7.44e-02 1.59e-01
SIGNALING BY CSF3 G CSF 29 1.88e-01 3.70e-01 0.20000 -0.094300 -0.177000 3.80e-01 9.97e-02
ORGANIC CATION ANION ZWITTERION TRANSPORT 10 5.47e-02 1.60e-01 0.19900 0.180000 -0.086900 3.26e-01 6.34e-01
MUCOPOLYSACCHARIDOSES 11 6.51e-01 7.79e-01 0.19900 0.160000 0.119000 3.58e-01 4.95e-01
RHO GTPASES ACTIVATE KTN1 11 4.21e-01 5.98e-01 0.19900 -0.072300 -0.185000 6.78e-01 2.88e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 1.24e-02 5.12e-02 0.19800 -0.196000 0.031200 1.30e-01 8.09e-01
ONCOGENE INDUCED SENESCENCE 32 3.53e-01 5.40e-01 0.19800 0.137000 0.143000 1.80e-01 1.60e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 24 3.50e-01 5.37e-01 0.19700 -0.165000 -0.108000 1.62e-01 3.58e-01
TRIGLYCERIDE METABOLISM 23 1.39e-01 3.01e-01 0.19700 -0.064500 -0.186000 5.92e-01 1.22e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 1.82e-01 3.63e-01 0.19700 -0.160000 -0.114000 6.90e-02 1.95e-01
INTERFERON GAMMA SIGNALING 73 3.78e-03 1.98e-02 0.19500 -0.182000 -0.070200 7.23e-03 3.00e-01
SIGNAL AMPLIFICATION 30 2.12e-01 3.98e-01 0.19400 -0.094200 -0.170000 3.72e-01 1.08e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 4.45e-01 6.23e-01 0.19400 -0.169000 -0.095100 2.43e-01 5.10e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 2.32e-01 4.19e-01 0.19400 0.091100 0.171000 4.13e-01 1.24e-01
HS GAG DEGRADATION 21 4.57e-01 6.34e-01 0.19400 0.156000 0.114000 2.16e-01 3.64e-01
NUCLEAR IMPORT OF REV PROTEIN 32 2.96e-03 1.65e-02 0.19300 -0.011300 0.193000 9.12e-01 5.90e-02
UCH PROTEINASES 90 4.69e-06 6.23e-05 0.19300 -0.020900 -0.192000 7.32e-01 1.66e-03
INWARDLY RECTIFYING K CHANNELS 31 1.37e-01 2.99e-01 0.19300 -0.079500 -0.175000 4.44e-01 9.09e-02
TRAFFICKING OF AMPA RECEPTORS 31 3.60e-01 5.46e-01 0.19200 0.122000 0.148000 2.40e-01 1.53e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 5.65e-01 7.17e-01 0.19100 0.119000 0.150000 3.94e-01 2.86e-01
SIGNALING BY PDGF 57 6.34e-02 1.78e-01 0.19100 0.094600 0.166000 2.17e-01 3.04e-02
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 4.23e-03 2.15e-02 0.19100 0.020600 0.189000 8.20e-01 3.58e-02
EXTRA NUCLEAR ESTROGEN SIGNALING 65 1.40e-01 3.01e-01 0.19100 -0.130000 -0.140000 7.09e-02 5.16e-02
GLUTAMATE AND GLUTAMINE METABOLISM 13 1.51e-01 3.17e-01 0.19000 0.189000 0.011100 2.37e-01 9.45e-01
POLYMERASE SWITCHING 14 3.40e-01 5.25e-01 0.19000 -0.064200 -0.178000 6.77e-01 2.48e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.27e-02 5.13e-02 0.18900 0.188000 -0.022000 1.19e-01 8.55e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 79 9.48e-02 2.34e-01 0.18900 -0.127000 -0.140000 5.15e-02 3.21e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 8.27e-05 7.68e-04 0.18800 0.000932 0.188000 9.90e-01 1.16e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 7.69e-02 2.04e-01 0.18800 -0.016900 -0.188000 8.98e-01 1.57e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 1.44e-01 3.06e-01 0.18800 0.186000 0.027300 1.97e-01 8.50e-01
INFLAMMASOMES 19 5.11e-01 6.73e-01 0.18800 -0.111000 -0.152000 4.02e-01 2.51e-01
SHC MEDIATED CASCADE FGFR3 13 6.83e-01 7.99e-01 0.18800 -0.130000 -0.136000 4.17e-01 3.96e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 1.64e-03 1.02e-02 0.18700 -0.012700 0.187000 8.93e-01 4.92e-02
FORMATION OF THE CORNIFIED ENVELOPE 29 2.22e-01 4.09e-01 0.18700 0.166000 0.086500 1.22e-01 4.20e-01
KERATINIZATION 29 2.22e-01 4.09e-01 0.18700 0.166000 0.086500 1.22e-01 4.20e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 1.19e-01 2.74e-01 0.18700 -0.071100 -0.173000 4.87e-01 9.05e-02
RHOH GTPASE CYCLE 37 1.99e-01 3.84e-01 0.18700 -0.096100 -0.160000 3.12e-01 9.21e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 3.19e-01 5.06e-01 0.18700 -0.061800 -0.176000 6.79e-01 2.38e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 6.69e-01 7.92e-01 0.18600 0.134000 0.130000 3.86e-01 4.00e-01
SIGNALING BY HIPPO 20 1.81e-01 3.63e-01 0.18600 -0.178000 -0.052800 1.68e-01 6.83e-01
SIGNALING BY FGFR1 IN DISEASE 32 1.46e-02 5.79e-02 0.18500 -0.184000 -0.015300 7.09e-02 8.81e-01
HEME BIOSYNTHESIS 13 6.70e-01 7.92e-01 0.18500 0.143000 0.117000 3.71e-01 4.65e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.44e-02 8.54e-02 0.18400 -0.071500 -0.170000 3.43e-01 2.41e-02
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 2.99e-03 1.66e-02 0.18400 0.080100 0.166000 1.53e-01 3.08e-03
RND2 GTPASE CYCLE 38 2.24e-01 4.11e-01 0.18400 0.098700 0.155000 2.93e-01 9.83e-02
P75NTR RECRUITS SIGNALLING COMPLEXES 13 1.39e-01 3.01e-01 0.18400 0.184000 -0.000930 2.51e-01 9.95e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 7.21e-01 8.23e-01 0.18400 0.118000 0.141000 4.98e-01 4.19e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 2.68e-01 4.57e-01 0.18400 -0.079300 -0.166000 5.02e-01 1.60e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 3.62e-01 5.47e-01 0.18300 0.173000 0.061700 2.63e-01 6.90e-01
INTERLEUKIN 15 SIGNALING 12 1.95e-01 3.77e-01 0.18300 0.009920 0.183000 9.53e-01 2.73e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 2.18e-01 4.05e-01 0.18300 -0.066900 -0.170000 5.79e-01 1.58e-01
SENSORY PROCESSING OF SOUND 60 1.92e-01 3.75e-01 0.18300 0.129000 0.129000 8.32e-02 8.39e-02
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.94e-01 3.77e-01 0.18200 0.166000 0.076200 1.22e-01 4.77e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 23 5.33e-01 6.89e-01 0.18200 -0.128000 -0.130000 2.88e-01 2.82e-01
METALLOPROTEASE DUBS 26 3.90e-01 5.72e-01 0.18200 -0.101000 -0.151000 3.72e-01 1.83e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 1.11e-02 4.67e-02 0.18200 0.001460 0.182000 9.89e-01 8.01e-02
ION TRANSPORT BY P TYPE ATPASES 48 2.66e-02 9.19e-02 0.18100 0.056600 0.172000 4.98e-01 3.91e-02
DISEASES OF CARBOHYDRATE METABOLISM 29 2.13e-03 1.25e-02 0.18100 0.174000 -0.052300 1.06e-01 6.26e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 4.09e-02 1.31e-01 0.18100 0.096200 0.153000 1.30e-01 1.60e-02
RHO GTPASES ACTIVATE PKNS 47 1.46e-02 5.79e-02 0.18100 -0.043300 -0.175000 6.08e-01 3.77e-02
FATTY ACID METABOLISM 145 2.93e-07 4.70e-06 0.18000 -0.031100 -0.177000 5.19e-01 2.29e-04
HATS ACETYLATE HISTONES 92 6.23e-02 1.77e-01 0.18000 0.110000 0.142000 6.74e-02 1.87e-02
METABOLISM OF FOLATE AND PTERINES 15 4.43e-01 6.23e-01 0.17900 0.163000 0.075400 2.75e-01 6.13e-01
ACYL CHAIN REMODELLING OF PS 14 6.89e-01 8.02e-01 0.17900 0.124000 0.130000 4.23e-01 4.01e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 1.84e-01 3.66e-01 0.17900 0.099700 0.149000 2.32e-01 7.44e-02
INTERLEUKIN 1 SIGNALING 96 8.09e-03 3.60e-02 0.17900 -0.078900 -0.160000 1.82e-01 6.68e-03
CARDIAC CONDUCTION 108 2.63e-02 9.12e-02 0.17800 0.101000 0.147000 6.96e-02 8.39e-03
BETA CATENIN PHOSPHORYLATION CASCADE 16 3.66e-01 5.49e-01 0.17800 -0.166000 -0.065400 2.51e-01 6.51e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 1.14e-02 4.77e-02 0.17800 -0.175000 0.030100 1.30e-01 7.94e-01
TNF SIGNALING 43 2.32e-01 4.19e-01 0.17700 0.099500 0.147000 2.59e-01 9.61e-02
SEMAPHORIN INTERACTIONS 64 1.66e-01 3.41e-01 0.17700 0.137000 0.112000 5.80e-02 1.21e-01
ATTENUATION PHASE 23 5.69e-03 2.74e-02 0.17700 0.162000 -0.072500 1.80e-01 5.47e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 6.73e-01 7.94e-01 0.17700 -0.096000 -0.149000 5.81e-01 3.93e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 7.31e-01 8.33e-01 0.17700 0.121000 0.129000 4.68e-01 4.39e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 6.70e-01 7.92e-01 0.17700 -0.132000 -0.117000 3.75e-01 4.31e-01
ADHERENS JUNCTIONS INTERACTIONS 29 4.58e-01 6.34e-01 0.17700 -0.134000 -0.116000 2.13e-01 2.80e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 16 2.77e-01 4.64e-01 0.17600 -0.046600 -0.169000 7.47e-01 2.41e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 186 6.56e-03 3.10e-02 0.17600 0.112000 0.135000 8.26e-03 1.53e-03
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 8.48e-02 2.19e-01 0.17600 0.066500 0.162000 4.56e-01 6.86e-02
HCMV EARLY EVENTS 80 1.28e-01 2.87e-01 0.17500 0.129000 0.119000 4.63e-02 6.63e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 1.17e-01 2.70e-01 0.17500 -0.037900 -0.171000 7.48e-01 1.47e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 1.68e-02 6.41e-02 0.17500 0.040300 -0.170000 7.43e-01 1.68e-01
DISEASES OF MITOTIC CELL CYCLE 37 2.75e-01 4.62e-01 0.17500 -0.094700 -0.147000 3.19e-01 1.23e-01
NEUTROPHIL DEGRANULATION 383 2.75e-12 1.19e-10 0.17500 -0.053700 -0.166000 7.19e-02 2.61e-08
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 1.78e-03 1.09e-02 0.17400 -0.112000 0.133000 3.21e-01 2.41e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 92 1.90e-04 1.55e-03 0.17400 -0.033200 -0.171000 5.82e-01 4.69e-03
DNA METHYLATION 20 4.56e-02 1.40e-01 0.17400 0.173000 -0.015700 1.80e-01 9.03e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.69e-01 7.19e-01 0.17300 -0.149000 -0.089300 3.19e-01 5.49e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 6.03e-01 7.47e-01 0.17300 0.155000 0.078200 3.75e-01 6.53e-01
GLYCOSAMINOGLYCAN METABOLISM 114 5.12e-02 1.53e-01 0.17300 0.132000 0.112000 1.49e-02 3.96e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 2.71e-01 4.60e-01 0.17300 0.001930 0.173000 9.92e-01 3.44e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 6.47e-03 3.08e-02 0.17200 -0.013400 0.171000 8.92e-01 8.38e-02
MICRORNA MIRNA BIOGENESIS 24 4.87e-01 6.57e-01 0.17200 0.139000 0.100000 2.37e-01 3.96e-01
RHOU GTPASE CYCLE 33 1.36e-02 5.47e-02 0.17200 0.000703 0.172000 9.94e-01 8.81e-02
PLASMA LIPOPROTEIN REMODELING 15 2.84e-02 9.72e-02 0.17200 0.127000 -0.116000 3.95e-01 4.39e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 3.62e-03 1.92e-02 0.17100 0.161000 0.057600 8.41e-03 3.45e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 597 4.03e-23 3.15e-21 0.17000 -0.032800 -0.167000 1.72e-01 3.82e-12
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 31 2.39e-01 4.27e-01 0.17000 0.153000 0.074600 1.41e-01 4.72e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 3.66e-01 5.49e-01 0.17000 0.127000 0.113000 1.59e-01 2.11e-01
RND3 GTPASE CYCLE 38 3.37e-01 5.24e-01 0.17000 0.100000 0.137000 2.85e-01 1.44e-01
RNA POLYMERASE III CHAIN ELONGATION 18 1.74e-01 3.53e-01 0.17000 -0.025300 -0.168000 8.52e-01 2.18e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 3.19e-01 5.05e-01 0.17000 -0.158000 -0.061900 2.22e-01 6.32e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 3.65e-01 5.49e-01 0.16900 -0.076500 -0.151000 5.25e-01 2.10e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 6.86e-01 8.01e-01 0.16900 0.098800 0.137000 5.37e-01 3.92e-01
RESOLUTION OF SISTER CHROMATID COHESION 101 8.32e-02 2.16e-01 0.16900 -0.110000 -0.128000 5.69e-02 2.61e-02
CA DEPENDENT EVENTS 36 7.83e-02 2.07e-01 0.16900 0.047600 0.162000 6.21e-01 9.30e-02
GLUTATHIONE CONJUGATION 29 4.23e-02 1.32e-01 0.16800 -0.014200 -0.168000 8.95e-01 1.18e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 5.68e-01 7.19e-01 0.16800 0.122000 0.116000 3.02e-01 3.24e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 1.08e-01 2.58e-01 0.16800 0.037600 -0.164000 8.14e-01 3.06e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 1.30e-01 2.90e-01 0.16700 -0.094600 -0.137000 1.75e-01 4.85e-02
RUNX2 REGULATES BONE DEVELOPMENT 29 4.15e-01 5.96e-01 0.16700 0.093200 0.138000 3.85e-01 1.97e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 5.41e-01 6.95e-01 0.16700 -0.089700 -0.141000 4.98e-01 2.89e-01
SODIUM CALCIUM EXCHANGERS 10 1.13e-01 2.63e-01 0.16600 -0.136000 0.095800 4.56e-01 6.00e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 6.88e-01 8.01e-01 0.16600 0.133000 0.100000 3.89e-01 5.17e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.07e-03 7.10e-03 0.16600 -0.094500 -0.137000 1.24e-02 2.97e-04
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 4.55e-01 6.33e-01 0.16600 -0.075600 -0.148000 5.68e-01 2.66e-01
INTERLEUKIN 7 SIGNALING 20 5.32e-01 6.89e-01 0.16500 0.089200 0.139000 4.90e-01 2.82e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 1.32e-01 2.92e-01 0.16400 0.159000 -0.041800 3.40e-01 8.02e-01
P38MAPK EVENTS 12 3.31e-01 5.18e-01 0.16400 0.162000 0.023300 3.31e-01 8.89e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.09e-01 4.98e-01 0.16300 0.124000 0.107000 1.27e-01 1.86e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 3.16e-01 5.01e-01 0.16300 0.112000 0.119000 1.62e-01 1.38e-01
L1CAM INTERACTIONS 107 7.22e-02 1.94e-01 0.16300 0.128000 0.101000 2.20e-02 7.10e-02
FCERI MEDIATED MAPK ACTIVATION 28 5.41e-01 6.95e-01 0.16300 -0.113000 -0.117000 3.00e-01 2.84e-01
INTERFERON SIGNALING 161 2.13e-05 2.27e-04 0.16300 -0.157000 -0.044600 6.16e-04 3.29e-01
CHROMOSOME MAINTENANCE 101 6.70e-03 3.15e-02 0.16300 -0.062300 -0.150000 2.80e-01 9.18e-03
RHOV GTPASE CYCLE 32 3.59e-03 1.92e-02 0.16200 -0.053100 0.153000 6.03e-01 1.34e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 1.51e-01 3.17e-01 0.16200 -0.024500 0.160000 8.78e-01 3.18e-01
RHO GTPASES ACTIVATE ROCKS 19 4.14e-02 1.31e-01 0.16200 0.045200 -0.155000 7.33e-01 2.41e-01
PURINE SALVAGE 12 6.95e-01 8.08e-01 0.16200 -0.087100 -0.136000 6.01e-01 4.14e-01
ION CHANNEL TRANSPORT 139 2.37e-02 8.43e-02 0.16100 0.092500 0.132000 6.00e-02 7.26e-03
FRS MEDIATED FGFR1 SIGNALING 16 7.00e-01 8.09e-01 0.16100 -0.121000 -0.106000 4.01e-01 4.63e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 3.73e-01 5.57e-01 0.16000 -0.068000 -0.145000 5.73e-01 2.28e-01
CS DS DEGRADATION 14 2.09e-01 3.94e-01 0.16000 0.160000 0.002020 3.00e-01 9.90e-01
NUCLEAR ENVELOPE BREAKDOWN 49 9.13e-03 3.99e-02 0.16000 0.015300 0.159000 8.53e-01 5.43e-02
G ALPHA S SIGNALLING EVENTS 97 9.40e-02 2.33e-01 0.15900 0.127000 0.095900 3.05e-02 1.03e-01
DERMATAN SULFATE BIOSYNTHESIS 11 4.49e-01 6.27e-01 0.15900 0.155000 0.035600 3.73e-01 8.38e-01
SIGNALING BY EGFR IN CANCER 21 2.50e-01 4.39e-01 0.15800 -0.041100 -0.153000 7.45e-01 2.25e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 3.05e-02 1.03e-01 0.15800 -0.158000 -0.007610 1.11e-01 9.39e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 3.35e-03 1.82e-02 0.15800 0.079200 -0.137000 4.53e-01 1.94e-01
PROTEIN FOLDING 89 1.40e-05 1.60e-04 0.15800 0.012900 -0.157000 8.33e-01 1.03e-02
SHC1 EVENTS IN ERBB4 SIGNALING 12 6.34e-01 7.63e-01 0.15800 -0.141000 -0.071500 3.98e-01 6.68e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.36e-01 5.24e-01 0.15800 -0.017800 -0.157000 9.15e-01 3.47e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 6.29e-01 7.60e-01 0.15800 -0.137000 -0.078400 3.75e-01 6.12e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 3.61e-01 5.46e-01 0.15800 -0.071600 -0.140000 5.20e-01 2.06e-01
SULFUR AMINO ACID METABOLISM 22 1.22e-02 5.04e-02 0.15700 0.113000 -0.110000 3.59e-01 3.73e-01
REGULATION OF TNFR1 SIGNALING 34 4.93e-01 6.60e-01 0.15700 0.117000 0.105000 2.39e-01 2.88e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 3.39e-01 5.25e-01 0.15700 0.057000 0.146000 6.44e-01 2.36e-01
GRB2 EVENTS IN ERBB2 SIGNALING 14 5.01e-01 6.64e-01 0.15700 -0.146000 -0.056600 3.44e-01 7.14e-01
MEIOSIS 63 2.61e-01 4.48e-01 0.15600 -0.119000 -0.101000 1.02e-01 1.65e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 1.38e-01 3.00e-01 0.15600 0.155000 -0.020700 2.99e-01 8.90e-01
MRNA SPLICING MINOR PATHWAY 52 1.77e-04 1.48e-03 0.15600 0.054300 -0.146000 4.98e-01 6.78e-02
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 5.67e-03 2.74e-02 0.15600 0.150000 0.044400 1.65e-02 4.77e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.12e-01 8.17e-01 0.15600 0.126000 0.092300 4.15e-01 5.50e-01
INTEGRATION OF ENERGY METABOLISM 97 1.41e-01 3.01e-01 0.15600 0.106000 0.114000 7.03e-02 5.24e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 5.34e-01 6.91e-01 0.15600 0.067700 0.140000 6.39e-01 3.31e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 2.19e-01 4.07e-01 0.15600 0.145000 0.057700 1.57e-01 5.72e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 2.73e-01 4.62e-01 0.15500 -0.101000 -0.118000 1.70e-01 1.08e-01
CD28 CO STIMULATION 30 3.02e-01 4.87e-01 0.15500 -0.140000 -0.066000 1.83e-01 5.32e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.86e-01 5.70e-01 0.15500 0.152000 0.030400 3.44e-01 8.49e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 3.37e-01 5.24e-01 0.15400 0.153000 0.020100 3.40e-01 9.00e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 2.10e-01 3.94e-01 0.15400 0.054500 0.144000 5.94e-01 1.58e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 2.17e-01 4.05e-01 0.15400 0.086200 0.127000 2.48e-01 8.88e-02
JOSEPHIN DOMAIN DUBS 11 1.33e-01 2.92e-01 0.15300 0.129000 -0.083600 4.60e-01 6.31e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.22e-03 1.29e-02 0.15300 -0.152000 -0.018800 2.47e-02 7.82e-01
SIGNALING BY FGFR2 IIIA TM 19 1.09e-01 2.58e-01 0.15300 0.010800 -0.153000 9.35e-01 2.49e-01
PROLACTIN RECEPTOR SIGNALING 11 1.32e-01 2.91e-01 0.15300 -0.087500 0.126000 6.15e-01 4.70e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 8.19e-01 8.84e-01 0.15300 -0.101000 -0.114000 5.79e-01 5.31e-01
NEGATIVE REGULATION OF FLT3 15 3.93e-01 5.75e-01 0.15200 0.147000 0.038400 3.23e-01 7.97e-01
ION HOMEOSTASIS 49 3.26e-01 5.12e-01 0.15200 0.090000 0.123000 2.76e-01 1.38e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 7.45e-03 3.43e-02 0.15200 -0.043000 0.146000 6.69e-01 1.47e-01
INTEGRIN CELL SURFACE INTERACTIONS 71 1.56e-01 3.23e-01 0.15200 0.082600 0.127000 2.29e-01 6.36e-02
RHO GTPASE CYCLE 422 3.87e-06 5.26e-05 0.15200 0.075700 0.131000 7.79e-03 3.88e-06
RECEPTOR MEDIATED MITOPHAGY 11 4.88e-01 6.57e-01 0.15200 -0.034600 -0.148000 8.43e-01 3.97e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 4.71e-01 6.46e-01 0.15100 0.069500 0.134000 5.72e-01 2.75e-01
PI 3K CASCADE FGFR1 14 5.43e-01 6.97e-01 0.15100 -0.140000 -0.057500 3.65e-01 7.10e-01
PCP CE PATHWAY 91 8.15e-05 7.63e-04 0.15100 0.001780 -0.151000 9.77e-01 1.27e-02
OXIDATIVE STRESS INDUCED SENESCENCE 78 1.87e-01 3.70e-01 0.15100 0.120000 0.092300 6.79e-02 1.59e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 3.20e-01 5.06e-01 0.15100 -0.148000 -0.028300 3.04e-01 8.45e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 1.35e-03 8.68e-03 0.15000 -0.089700 0.120000 3.45e-01 2.05e-01
PLASMA LIPOPROTEIN CLEARANCE 26 4.34e-02 1.34e-01 0.15000 0.149000 -0.018900 1.89e-01 8.68e-01
FANCONI ANEMIA PATHWAY 36 2.42e-01 4.28e-01 0.15000 0.137000 0.061200 1.55e-01 5.25e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 7.77e-01 8.61e-01 0.15000 0.113000 0.097800 4.79e-01 5.41e-01
DAP12 INTERACTIONS 29 4.16e-01 5.96e-01 0.14900 -0.130000 -0.073100 2.25e-01 4.96e-01
BIOLOGICAL OXIDATIONS 122 9.43e-05 8.53e-04 0.14900 -0.021300 -0.148000 6.84e-01 4.85e-03
PEROXISOMAL LIPID METABOLISM 26 6.04e-01 7.48e-01 0.14900 -0.114000 -0.096600 3.16e-01 3.94e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 6.11e-02 1.74e-01 0.14800 -0.137000 0.057600 3.15e-01 6.72e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 9.41e-02 2.33e-01 0.14800 -0.006120 -0.148000 9.57e-01 1.92e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 1.90e-01 3.73e-01 0.14800 0.036800 0.143000 7.36e-01 1.89e-01
G PROTEIN MEDIATED EVENTS 52 4.89e-02 1.48e-01 0.14700 0.037100 0.142000 6.44e-01 7.58e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 3.91e-01 5.72e-01 0.14700 -0.010100 -0.147000 9.54e-01 4.00e-01
M PHASE 339 1.08e-03 7.12e-03 0.14700 -0.089100 -0.117000 4.91e-03 2.32e-04
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 1.12e-01 2.62e-01 0.14700 -0.004010 -0.146000 9.73e-01 2.14e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 6.36e-02 1.78e-01 0.14700 -0.093200 0.113000 5.19e-01 4.34e-01
RHO GTPASES ACTIVATE PAKS 21 2.81e-01 4.68e-01 0.14600 -0.033200 -0.142000 7.92e-01 2.60e-01
LDL CLEARANCE 16 7.06e-02 1.91e-01 0.14600 0.081000 -0.121000 5.75e-01 4.02e-01
SIGNALING BY WNT IN CANCER 30 1.65e-01 3.40e-01 0.14500 0.033200 0.142000 7.53e-01 1.80e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 1.30e-01 2.90e-01 0.14500 0.024700 -0.143000 8.60e-01 3.06e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 1.22e-01 2.78e-01 0.14500 -0.054900 -0.135000 4.94e-01 9.33e-02
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 6.70e-01 7.92e-01 0.14500 -0.117000 -0.085600 3.76e-01 5.18e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 6.66e-01 7.90e-01 0.14500 -0.120000 -0.081900 3.79e-01 5.48e-01
ERK MAPK TARGETS 22 5.73e-01 7.20e-01 0.14500 0.075900 0.123000 5.38e-01 3.18e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 4.10e-01 5.92e-01 0.14400 -0.003740 -0.144000 9.84e-01 4.29e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 2.89e-01 4.77e-01 0.14400 -0.144000 0.010100 3.88e-01 9.52e-01
CD28 DEPENDENT PI3K AKT SIGNALING 20 2.47e-01 4.34e-01 0.14400 0.022000 0.143000 8.65e-01 2.69e-01
PERK REGULATES GENE EXPRESSION 28 6.20e-01 7.59e-01 0.14400 -0.103000 -0.100000 3.45e-01 3.59e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 4.21e-01 5.98e-01 0.14400 -0.088700 -0.113000 3.03e-01 1.89e-01
FRS MEDIATED FGFR3 SIGNALING 15 7.75e-01 8.60e-01 0.14400 -0.102000 -0.101000 4.93e-01 4.99e-01
LYSOSOME VESICLE BIOGENESIS 32 9.73e-02 2.40e-01 0.14300 -0.017600 -0.142000 8.64e-01 1.65e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 139 1.52e-02 5.98e-02 0.14200 0.127000 0.065300 1.01e-02 1.84e-01
COSTIMULATION BY THE CD28 FAMILY 49 2.36e-01 4.23e-01 0.14200 -0.126000 -0.066400 1.28e-01 4.22e-01
SARS COV 1 INFECTION 48 3.99e-02 1.28e-01 0.14200 -0.022400 -0.140000 7.88e-01 9.24e-02
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 1.81e-01 3.63e-01 0.14200 -0.119000 0.076400 4.94e-01 6.61e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 2.89e-01 4.77e-01 0.14100 -0.035100 0.137000 8.47e-01 4.53e-01
UNFOLDED PROTEIN RESPONSE UPR 85 2.36e-01 4.23e-01 0.14100 0.106000 0.093100 9.11e-02 1.38e-01
PYRIMIDINE SALVAGE 10 4.44e-01 6.23e-01 0.14100 0.141000 0.007170 4.41e-01 9.69e-01
REPRODUCTION 75 2.90e-01 4.77e-01 0.14100 -0.103000 -0.095700 1.22e-01 1.52e-01
MAP2K AND MAPK ACTIVATION 36 5.23e-01 6.82e-01 0.14000 0.110000 0.086700 2.55e-01 3.68e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 3.81e-01 5.65e-01 0.14000 0.006410 0.140000 9.69e-01 4.03e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 5.89e-02 1.69e-01 0.14000 -0.026500 -0.137000 7.53e-01 1.04e-01
COMPLEMENT CASCADE 24 3.13e-01 5.00e-01 0.13900 -0.039200 -0.134000 7.40e-01 2.57e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 6.17e-01 7.58e-01 0.13900 0.095800 0.101000 3.64e-01 3.38e-01
PEROXISOMAL PROTEIN IMPORT 57 2.22e-01 4.09e-01 0.13900 -0.067700 -0.121000 3.77e-01 1.13e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 6.78e-01 7.96e-01 0.13900 -0.106000 -0.089600 3.78e-01 4.57e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 5.34e-02 1.57e-01 0.13900 0.032100 0.135000 6.83e-01 8.61e-02
PROLONGED ERK ACTIVATION EVENTS 13 5.23e-01 6.82e-01 0.13800 -0.133000 -0.036500 4.05e-01 8.20e-01
TP53 REGULATES METABOLIC GENES 85 5.77e-02 1.67e-01 0.13800 -0.055900 -0.126000 3.73e-01 4.44e-02
ONCOGENIC MAPK SIGNALING 77 2.58e-01 4.45e-01 0.13800 0.085300 0.108000 1.96e-01 1.00e-01
HIV ELONGATION ARREST AND RECOVERY 32 1.07e-01 2.56e-01 0.13800 0.137000 0.014900 1.79e-01 8.84e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 8.13e-01 8.80e-01 0.13800 0.093200 0.102000 5.61e-01 5.26e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 4.93e-01 6.60e-01 0.13700 -0.070700 -0.118000 5.03e-01 2.65e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 3.48e-03 1.88e-02 0.13700 -0.016500 0.136000 8.29e-01 7.65e-02
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 343 5.17e-03 2.53e-02 0.13700 -0.092600 -0.101000 3.28e-03 1.41e-03
PROCESSING OF INTRONLESS PRE MRNAS 19 4.26e-01 6.05e-01 0.13700 -0.131000 -0.040500 3.25e-01 7.60e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 7.97e-01 8.69e-01 0.13600 0.075200 0.114000 6.66e-01 5.14e-01
GLUCOSE METABOLISM 80 1.06e-01 2.56e-01 0.13600 0.121000 0.061900 6.09e-02 3.38e-01
NUCLEOBASE CATABOLISM 31 5.73e-01 7.20e-01 0.13600 -0.081600 -0.109000 4.32e-01 2.94e-01
NOD1 2 SIGNALING PATHWAY 34 2.01e-01 3.86e-01 0.13600 0.037000 0.131000 7.09e-01 1.87e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.39e-01 5.25e-01 0.13600 -0.136000 0.001290 3.97e-01 9.94e-01
MITOTIC G2 G2 M PHASES 186 1.78e-03 1.09e-02 0.13500 -0.051300 -0.124000 2.28e-01 3.45e-03
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 5.17e-01 6.78e-01 0.13400 -0.121000 -0.056900 3.24e-01 6.44e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 168 1.91e-02 7.10e-02 0.13400 0.116000 0.066700 9.40e-03 1.37e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 7.87e-01 8.66e-01 0.13400 0.116000 0.066200 5.24e-01 7.17e-01
INFECTIOUS DISEASE 721 8.72e-15 4.44e-13 0.13400 -0.035200 -0.129000 1.09e-01 4.17e-09
CELL CYCLE MITOTIC 474 5.59e-04 3.91e-03 0.13300 -0.083400 -0.104000 1.94e-03 1.09e-04
THE NLRP3 INFLAMMASOME 15 6.17e-01 7.58e-01 0.13300 -0.052900 -0.122000 7.23e-01 4.12e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 1.25e-01 2.82e-01 0.13300 0.118000 -0.060300 4.13e-01 6.76e-01
VIRAL MESSENGER RNA SYNTHESIS 42 2.96e-01 4.83e-01 0.13300 0.056700 0.120000 5.25e-01 1.79e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 5.20e-01 6.80e-01 0.13200 0.025000 0.130000 8.81e-01 4.36e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 2.33e-01 4.19e-01 0.13200 0.004760 0.132000 9.71e-01 3.08e-01
METABOLISM OF NUCLEOTIDES 92 6.64e-02 1.85e-01 0.13100 -0.054500 -0.120000 3.66e-01 4.76e-02
CELL CYCLE 591 2.58e-04 2.02e-03 0.13100 -0.087900 -0.097100 2.79e-04 5.88e-05
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 3.48e-01 5.36e-01 0.13100 0.103000 0.080500 1.47e-01 2.58e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 44 3.37e-01 5.24e-01 0.13100 -0.116000 -0.061400 1.85e-01 4.81e-01
CA2 PATHWAY 56 3.43e-02 1.14e-01 0.13100 -0.130000 -0.016700 9.36e-02 8.29e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 3.13e-01 5.00e-01 0.13100 -0.038000 -0.125000 7.28e-01 2.53e-01
SIGNALING BY ERBB4 56 2.87e-01 4.75e-01 0.13100 -0.113000 -0.065200 1.44e-01 3.99e-01
MET PROMOTES CELL MOTILITY 39 4.42e-01 6.23e-01 0.13000 0.067900 0.111000 4.64e-01 2.29e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 1.27e-02 5.13e-02 0.13000 -0.058100 0.117000 5.52e-01 2.33e-01
SPRY REGULATION OF FGF SIGNALING 16 3.90e-01 5.72e-01 0.13000 0.129000 0.017700 3.72e-01 9.03e-01
METABOLISM OF PORPHYRINS 19 3.94e-01 5.75e-01 0.13000 0.127000 0.028300 3.40e-01 8.31e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 5.51e-01 7.06e-01 0.12900 -0.120000 -0.047300 3.77e-01 7.28e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 1.83e-02 6.84e-02 0.12900 0.046000 -0.121000 6.38e-01 2.17e-01
CIRCADIAN CLOCK 68 2.20e-02 7.96e-02 0.12900 0.019200 0.128000 7.84e-01 6.90e-02
DNA STRAND ELONGATION 32 4.10e-01 5.92e-01 0.12900 -0.054400 -0.117000 5.95e-01 2.53e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 44 2.01e-01 3.86e-01 0.12900 0.122000 0.042100 1.63e-01 6.29e-01
TRANSCRIPTION OF THE HIV GENOME 67 3.98e-01 5.79e-01 0.12900 -0.094200 -0.087400 1.82e-01 2.16e-01
SIGNALING BY ERYTHROPOIETIN 24 6.26e-01 7.60e-01 0.12800 0.068300 0.109000 5.62e-01 3.56e-01
PI 3K CASCADE FGFR3 13 6.59e-01 7.85e-01 0.12800 -0.119000 -0.047900 4.57e-01 7.65e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 10 4.83e-01 6.54e-01 0.12800 0.000774 0.128000 9.97e-01 4.82e-01
ERKS ARE INACTIVATED 13 7.82e-01 8.63e-01 0.12800 0.108000 0.069400 5.01e-01 6.65e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 7.22e-02 1.94e-01 0.12700 0.067800 -0.108000 5.91e-01 3.93e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 3.12e-01 5.00e-01 0.12700 -0.113000 -0.058700 1.73e-01 4.78e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 2.40e-01 4.27e-01 0.12700 -0.093100 0.086000 5.93e-01 6.21e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 143 3.77e-02 1.24e-01 0.12600 -0.059400 -0.112000 2.21e-01 2.14e-02
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 6.47e-01 7.76e-01 0.12600 -0.088000 -0.090600 3.82e-01 3.68e-01
SELECTIVE AUTOPHAGY 71 1.11e-04 9.65e-04 0.12600 0.091400 -0.087000 1.83e-01 2.05e-01
ZINC TRANSPORTERS 16 8.10e-01 8.78e-01 0.12600 -0.092200 -0.085400 5.23e-01 5.54e-01
KERATAN SULFATE DEGRADATION 11 2.55e-01 4.44e-01 0.12600 0.072800 -0.102000 6.76e-01 5.57e-01
PLATELET CALCIUM HOMEOSTASIS 27 5.92e-01 7.37e-01 0.12500 0.065100 0.107000 5.58e-01 3.35e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 2.66e-01 4.54e-01 0.12500 -0.023200 -0.123000 8.34e-01 2.69e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 139 1.58e-02 6.15e-02 0.12500 -0.046900 -0.116000 3.40e-01 1.87e-02
SIGNALING BY NTRK3 TRKC 17 7.72e-01 8.60e-01 0.12500 0.074500 0.100000 5.95e-01 4.75e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 3.45e-01 5.32e-01 0.12500 0.092900 0.083100 1.48e-01 1.97e-01
MHC CLASS II ANTIGEN PRESENTATION 102 1.10e-05 1.31e-04 0.12400 0.053600 -0.112000 3.50e-01 5.06e-02
NEDDYLATION 218 1.02e-02 4.38e-02 0.12400 -0.060100 -0.109000 1.27e-01 5.76e-03
NEURONAL SYSTEM 366 2.29e-03 1.32e-02 0.12400 0.068600 0.103000 2.46e-02 7.33e-04
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 1.01e-01 2.46e-01 0.12400 0.000940 0.124000 9.92e-01 2.12e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 7.79e-01 8.62e-01 0.12300 0.056200 0.109000 7.47e-01 5.30e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 7.02e-01 8.10e-01 0.12300 -0.105000 -0.063800 4.29e-01 6.30e-01
G0 AND EARLY G1 25 6.62e-01 7.87e-01 0.12300 -0.102000 -0.068400 3.78e-01 5.54e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 1.27e-02 5.13e-02 0.12200 -0.036400 0.117000 6.73e-01 1.76e-01
PI3K AKT SIGNALING IN CANCER 87 1.49e-01 3.13e-01 0.12200 0.056100 0.108000 3.66e-01 8.19e-02
DAP12 SIGNALING 24 7.42e-01 8.43e-01 0.12200 -0.082300 -0.089600 4.85e-01 4.47e-01
SIGNALING BY GPCR 458 3.23e-03 1.78e-02 0.12100 0.078500 0.092500 4.12e-03 7.23e-04
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 1.42e-01 3.02e-01 0.12100 0.121000 0.004800 2.36e-01 9.63e-01
SIGNALING BY EGFR 46 5.03e-01 6.66e-01 0.12000 0.069700 0.098300 4.13e-01 2.49e-01
AQUAPORIN MEDIATED TRANSPORT 40 3.13e-01 5.00e-01 0.12000 -0.042800 -0.112000 6.40e-01 2.22e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 2.09e-01 3.94e-01 0.11900 -0.111000 -0.043200 1.54e-01 5.79e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 4.69e-01 6.45e-01 0.11900 -0.083100 -0.085100 2.47e-01 2.36e-01
CELL CELL COMMUNICATION 106 2.50e-01 4.39e-01 0.11900 0.073200 0.093600 1.93e-01 9.63e-02
INNATE IMMUNE SYSTEM 770 8.13e-11 3.17e-09 0.11900 -0.038200 -0.112000 7.33e-02 1.35e-07
RA BIOSYNTHESIS PATHWAY 14 5.26e-01 6.83e-01 0.11800 -0.019200 -0.117000 9.01e-01 4.50e-01
ARACHIDONIC ACID METABOLISM 39 2.95e-02 1.00e-01 0.11800 0.034600 -0.113000 7.08e-01 2.23e-01
ANTIMICROBIAL PEPTIDES 12 2.74e-01 4.62e-01 0.11800 0.063200 -0.099600 7.05e-01 5.50e-01
METABOLISM OF CARBOHYDRATES 257 2.87e-04 2.23e-03 0.11800 0.112000 0.036600 2.01e-03 3.13e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 8.21e-03 3.64e-02 0.11800 0.096700 -0.067500 2.67e-01 4.39e-01
SIGNALING BY ERBB2 IN CANCER 24 3.89e-01 5.72e-01 0.11800 -0.115000 -0.027100 3.31e-01 8.18e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 1.07e-03 7.10e-03 0.11700 0.092000 -0.071900 2.07e-01 3.24e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 62 3.00e-01 4.86e-01 0.11600 -0.102000 -0.054400 1.63e-01 4.59e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 7.93e-01 8.69e-01 0.11500 -0.070800 -0.090100 5.93e-01 4.96e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.62e-01 4.49e-01 0.11400 -0.014900 0.113000 9.11e-01 3.92e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 4.84e-03 2.40e-02 0.11400 -0.113000 0.018200 9.54e-02 7.88e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 4.96e-01 6.61e-01 0.11400 0.073000 0.087600 3.24e-01 2.37e-01
SARS COV 2 INFECTION 65 6.75e-02 1.87e-01 0.11400 -0.020100 -0.112000 7.80e-01 1.18e-01
HIV LIFE CYCLE 142 2.19e-01 4.07e-01 0.11400 -0.077800 -0.082900 1.10e-01 8.85e-02
CTLA4 INHIBITORY SIGNALING 20 6.78e-01 7.96e-01 0.11300 -0.051400 -0.101000 6.90e-01 4.35e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 4.21e-01 5.98e-01 0.11300 0.048200 0.102000 5.93e-01 2.58e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 8.80e-01 9.21e-01 0.11300 0.083000 0.076600 6.19e-01 6.46e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.16e-01 5.01e-01 0.11300 0.054700 -0.098800 7.43e-01 5.54e-01
DISEASES OF DNA REPAIR 11 6.12e-01 7.54e-01 0.11200 -0.111000 -0.013900 5.24e-01 9.36e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 1.09e-01 2.58e-01 0.11200 0.081200 -0.076800 5.10e-01 5.33e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 8.37e-01 8.96e-01 0.11200 0.082600 0.075000 5.55e-01 5.92e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 101 2.74e-01 4.62e-01 0.11100 0.090900 0.063800 1.15e-01 2.69e-01
SIGNALING BY RETINOIC ACID 34 4.97e-01 6.62e-01 0.11100 -0.047100 -0.101000 6.35e-01 3.10e-01
INTERLEUKIN 1 FAMILY SIGNALING 122 9.09e-02 2.30e-01 0.11100 -0.048400 -0.099900 3.56e-01 5.70e-02
HEDGEHOG ON STATE 83 7.43e-03 3.43e-02 0.11100 0.005620 -0.111000 9.29e-01 8.13e-02
HEME SIGNALING 44 2.39e-02 8.49e-02 0.11100 -0.040300 0.103000 6.44e-01 2.36e-01
CD209 DC SIGN SIGNALING 18 8.33e-01 8.94e-01 0.11100 -0.078300 -0.078400 5.65e-01 5.65e-01
RHO GTPASES ACTIVATE CIT 18 1.69e-01 3.45e-01 0.11100 0.081700 -0.074700 5.48e-01 5.83e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 7.76e-01 8.60e-01 0.11100 -0.051000 -0.098100 7.41e-01 5.25e-01
PREGNENOLONE BIOSYNTHESIS 12 3.23e-01 5.09e-01 0.11100 0.094100 -0.058100 5.73e-01 7.28e-01
MYOGENESIS 25 2.66e-01 4.54e-01 0.11000 0.001540 0.110000 9.89e-01 3.40e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 8.87e-01 9.28e-01 0.11000 0.078400 0.077100 6.38e-01 6.44e-01
INTERLEUKIN 27 SIGNALING 10 8.16e-01 8.83e-01 0.11000 0.046300 0.099600 8.00e-01 5.85e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 6.98e-01 8.09e-01 0.11000 0.082300 0.072700 4.00e-01 4.57e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 15 7.11e-01 8.17e-01 0.10900 0.101000 0.041300 4.98e-01 7.82e-01
HCMV INFECTION 103 6.77e-02 1.87e-01 0.10900 0.103000 0.035600 7.11e-02 5.32e-01
REGULATION OF IFNA SIGNALING 12 8.50e-01 9.05e-01 0.10900 0.059100 0.091300 7.23e-01 5.84e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 7.52e-01 8.48e-01 0.10800 0.044200 0.098500 7.75e-01 5.24e-01
ERBB2 REGULATES CELL MOTILITY 13 3.12e-01 5.00e-01 0.10800 -0.056300 0.092000 7.25e-01 5.66e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 7.50e-01 8.48e-01 0.10800 -0.103000 -0.030600 5.72e-01 8.67e-01
STRIATED MUSCLE CONTRACTION 28 1.41e-01 3.01e-01 0.10700 0.024700 -0.104000 8.21e-01 3.39e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 12 4.19e-01 5.98e-01 0.10700 0.028200 -0.104000 8.66e-01 5.35e-01
EPHRIN SIGNALING 19 6.20e-01 7.59e-01 0.10700 0.101000 0.035200 4.46e-01 7.91e-01
HS GAG BIOSYNTHESIS 29 1.92e-01 3.75e-01 0.10700 -0.007930 0.106000 9.41e-01 3.21e-01
PECAM1 INTERACTIONS 12 8.88e-01 9.28e-01 0.10700 0.080900 0.069400 6.27e-01 6.77e-01
SIGNALING BY INSULIN RECEPTOR 61 3.91e-01 5.72e-01 0.10700 -0.052000 -0.092900 4.82e-01 2.09e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 7.71e-01 8.60e-01 0.10600 -0.047800 -0.094700 7.49e-01 5.25e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 4.67e-01 6.43e-01 0.10600 0.106000 0.010200 4.38e-01 9.40e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 542 6.83e-03 3.18e-02 0.10600 -0.078700 -0.071100 1.80e-03 4.80e-03
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 4.35e-01 6.15e-01 0.10600 -0.079600 -0.069800 1.99e-01 2.61e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 1.80e-01 3.61e-01 0.10600 0.046500 -0.094900 7.12e-01 4.51e-01
NICOTINATE METABOLISM 24 5.41e-01 6.95e-01 0.10500 0.032600 0.100000 7.82e-01 3.97e-01
SIGNALING BY PTK6 50 4.93e-01 6.60e-01 0.10500 0.090400 0.052900 2.69e-01 5.18e-01
PYRIMIDINE CATABOLISM 10 6.06e-01 7.48e-01 0.10400 0.002040 -0.104000 9.91e-01 5.68e-01
LYSINE CATABOLISM 10 7.59e-01 8.53e-01 0.10400 0.100000 0.028500 5.84e-01 8.76e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 4.96e-01 6.61e-01 0.10400 -0.041900 -0.094700 6.60e-01 3.19e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 3.39e-01 5.25e-01 0.10300 -0.054000 -0.088200 3.95e-01 1.65e-01
UB SPECIFIC PROCESSING PROTEASES 169 2.12e-01 3.97e-01 0.10300 -0.066800 -0.078500 1.34e-01 7.85e-02
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 2.28e-02 8.17e-02 0.10300 0.093100 -0.044300 2.60e-01 5.92e-01
SIGNALING BY NTRKS 129 2.26e-01 4.13e-01 0.10300 0.085300 0.057000 9.45e-02 2.64e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 25 6.78e-01 7.96e-01 0.10200 -0.047000 -0.090800 6.84e-01 4.32e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 622 3.01e-03 1.66e-02 0.10200 0.062900 0.080300 7.66e-03 6.67e-04
MUSCLE CONTRACTION 163 1.89e-01 3.72e-01 0.10200 0.082100 0.060100 7.09e-02 1.86e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 7.74e-01 8.60e-01 0.10200 -0.078100 -0.064900 4.75e-01 5.52e-01
DUAL INCISION IN TC NER 64 3.68e-01 5.52e-01 0.10100 -0.045700 -0.090300 5.28e-01 2.12e-01
SIGNALING BY INTERLEUKINS 346 5.39e-03 2.63e-02 0.10100 -0.046200 -0.090000 1.40e-01 4.12e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 8.72e-01 9.20e-01 0.10100 -0.055700 -0.084300 7.38e-01 6.13e-01
N GLYCAN ANTENNAE ELONGATION 15 8.73e-01 9.20e-01 0.10100 0.064500 0.077700 6.65e-01 6.02e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 3.76e-01 5.59e-01 0.10100 -0.100000 -0.010300 3.77e-01 9.27e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 8.29e-01 8.91e-01 0.10000 -0.083300 -0.056000 5.52e-01 6.89e-01
FOXO MEDIATED TRANSCRIPTION 57 5.61e-01 7.15e-01 0.10000 -0.058600 -0.081300 4.44e-01 2.88e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.20e-01 2.75e-01 0.10000 0.099600 -0.008210 2.64e-01 9.27e-01
NONHOMOLOGOUS END JOINING NHEJ 43 6.94e-01 8.07e-01 0.09990 -0.074700 -0.066300 3.97e-01 4.52e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 58 1.75e-02 6.63e-02 0.09960 0.038500 -0.091800 6.12e-01 2.27e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 6.21e-01 7.59e-01 0.09920 0.072900 0.067200 3.37e-01 3.76e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 2.92e-01 4.81e-01 0.09910 0.025600 -0.095800 8.43e-01 4.58e-01
AUTOPHAGY 137 2.13e-05 2.27e-04 0.09910 0.065200 -0.074600 1.88e-01 1.32e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 7.00e-01 8.09e-01 0.09900 -0.053000 -0.083700 6.10e-01 4.20e-01
EGFR DOWNREGULATION 27 7.89e-01 8.66e-01 0.09870 0.062400 0.076500 5.75e-01 4.91e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 4.57e-01 6.34e-01 0.09870 0.078300 0.060000 2.12e-01 3.39e-01
SIGNALING BY FGFR1 42 6.44e-01 7.74e-01 0.09850 -0.055400 -0.081500 5.35e-01 3.61e-01
RND1 GTPASE CYCLE 37 1.16e-01 2.69e-01 0.09840 -0.021800 0.096000 8.19e-01 3.12e-01
DNA DAMAGE RECOGNITION IN GG NER 38 7.65e-02 2.04e-01 0.09840 0.091100 -0.037100 3.31e-01 6.92e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 9.24e-01 9.50e-01 0.09800 -0.068000 -0.070600 7.10e-01 6.99e-01
PEPTIDE LIGAND BINDING RECEPTORS 93 4.70e-02 1.43e-01 0.09780 -0.013700 -0.096900 8.20e-01 1.07e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 1.09e-01 2.58e-01 0.09770 -0.069600 -0.068600 4.34e-02 4.64e-02
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 2.98e-01 4.84e-01 0.09760 0.095800 0.018500 2.88e-01 8.38e-01
FLT3 SIGNALING IN DISEASE 27 6.59e-01 7.85e-01 0.09640 -0.087300 -0.041000 4.32e-01 7.13e-01
TELOMERE MAINTENANCE 78 4.23e-02 1.32e-01 0.09600 -0.000506 -0.096000 9.94e-01 1.43e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 8.39e-02 2.17e-01 0.09540 -0.003300 -0.095300 9.63e-01 1.84e-01
INTERLEUKIN 17 SIGNALING 66 1.90e-01 3.72e-01 0.09510 0.022400 0.092400 7.53e-01 1.94e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 4.63e-01 6.39e-01 0.09510 0.095100 -0.000379 4.73e-01 9.98e-01
ADAPTIVE IMMUNE SYSTEM 596 8.77e-03 3.87e-02 0.09500 -0.059400 -0.074100 1.36e-02 2.09e-03
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 5.14e-01 6.75e-01 0.09430 -0.076600 -0.055000 2.55e-01 4.13e-01
RAB REGULATION OF TRAFFICKING 119 3.27e-01 5.13e-01 0.09420 0.053400 0.077600 3.14e-01 1.44e-01
RESOLUTION OF D LOOP STRUCTURES 30 1.33e-01 2.92e-01 0.09410 -0.081400 0.047200 4.40e-01 6.54e-01
TRNA AMINOACYLATION 42 5.10e-02 1.53e-01 0.09380 0.070200 -0.062300 4.31e-01 4.85e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 6.50e-01 7.79e-01 0.09360 0.042100 0.083600 6.80e-01 4.13e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 8.75e-01 9.20e-01 0.09350 -0.074200 -0.056800 6.07e-01 6.94e-01
BILE ACID AND BILE SALT METABOLISM 25 4.79e-01 6.54e-01 0.09330 0.014000 0.092200 9.04e-01 4.25e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 4.83e-01 6.54e-01 0.09280 0.089900 0.022700 3.86e-01 8.27e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 6.53e-01 7.80e-01 0.09270 -0.038500 -0.084300 7.20e-01 4.32e-01
SIGNALING BY ACTIVIN 12 4.44e-01 6.23e-01 0.09250 -0.054800 0.074400 7.42e-01 6.55e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 5.10e-01 6.73e-01 0.09160 -0.085100 -0.033900 3.46e-01 7.08e-01
RHOQ GTPASE CYCLE 57 4.16e-01 5.96e-01 0.09150 0.035800 0.084200 6.40e-01 2.72e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 6.75e-02 1.87e-01 0.09090 -0.045300 0.078800 6.07e-01 3.71e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 9.05e-01 9.41e-01 0.09070 -0.055900 -0.071500 7.27e-01 6.56e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 3.14e-01 5.00e-01 0.09060 -0.080300 0.041900 5.45e-01 7.52e-01
METAL ION SLC TRANSPORTERS 25 3.20e-01 5.06e-01 0.09040 -0.089200 0.014300 4.40e-01 9.02e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 3.15e-02 1.05e-01 0.09030 -0.005940 -0.090100 9.16e-01 1.07e-01
CELLULAR SENESCENCE 141 3.61e-01 5.46e-01 0.08980 0.069700 0.056700 1.54e-01 2.46e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 7.27e-01 8.29e-01 0.08970 0.089500 0.006070 6.24e-01 9.73e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 4.34e-01 6.13e-01 0.08930 -0.032700 -0.083100 6.81e-01 2.96e-01
FGFR2 ALTERNATIVE SPLICING 25 2.58e-01 4.45e-01 0.08920 0.031100 -0.083600 7.88e-01 4.70e-01
AMYLOID FIBER FORMATION 57 6.82e-02 1.88e-01 0.08920 0.087200 -0.018700 2.55e-01 8.08e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 5.71e-01 7.20e-01 0.08910 0.085600 0.024700 4.33e-01 8.21e-01
SYNTHESIS OF PC 25 8.28e-01 8.90e-01 0.08890 0.070700 0.053800 5.41e-01 6.41e-01
GLYCOLYSIS 66 6.18e-01 7.59e-01 0.08880 0.069700 0.054900 3.27e-01 4.41e-01
MITOTIC PROMETAPHASE 176 2.28e-01 4.15e-01 0.08860 -0.073300 -0.049800 9.40e-02 2.55e-01
PI3K EVENTS IN ERBB2 SIGNALING 14 4.13e-01 5.96e-01 0.08840 -0.060600 0.064300 6.95e-01 6.77e-01
PARASITE INFECTION 54 6.79e-01 7.96e-01 0.08830 0.054900 0.069200 4.85e-01 3.79e-01
NUCLEAR SIGNALING BY ERBB4 30 7.48e-01 8.47e-01 0.08830 0.045700 0.075600 6.65e-01 4.74e-01
OTHER INTERLEUKIN SIGNALING 19 5.72e-01 7.20e-01 0.08820 0.087800 0.008240 5.08e-01 9.50e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 43 6.02e-01 7.46e-01 0.08790 -0.039700 -0.078500 6.52e-01 3.73e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 5.13e-01 6.75e-01 0.08790 -0.083400 0.027800 6.03e-01 8.62e-01
SIGNALING BY SCF KIT 41 8.11e-02 2.13e-01 0.08750 -0.067700 0.055500 4.53e-01 5.39e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 2.04e-01 3.89e-01 0.08740 0.084400 -0.023000 4.02e-01 8.19e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 19 6.20e-01 7.59e-01 0.08720 -0.013900 -0.086100 9.16e-01 5.16e-01
G1 S SPECIFIC TRANSCRIPTION 26 2.79e-01 4.65e-01 0.08700 -0.083100 0.025600 4.63e-01 8.21e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 6.62e-01 7.87e-01 0.08680 0.084600 0.019300 5.23e-01 8.84e-01
ACYL CHAIN REMODELLING OF PG 10 8.70e-01 9.20e-01 0.08640 -0.079700 -0.033400 6.63e-01 8.55e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 1.20e-01 2.74e-01 0.08590 -0.084100 -0.017500 1.55e-01 7.67e-01
METABOLISM OF VITAMINS AND COFACTORS 150 7.50e-02 2.01e-01 0.08570 0.081700 0.025800 8.45e-02 5.86e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 6.78e-01 7.96e-01 0.08530 -0.040800 -0.075000 6.64e-01 4.24e-01
GLYCOSPHINGOLIPID METABOLISM 39 1.55e-01 3.23e-01 0.08490 0.080600 -0.026800 3.84e-01 7.72e-01
POTASSIUM CHANNELS 90 5.79e-01 7.24e-01 0.08490 0.056600 0.063200 3.54e-01 3.00e-01
DEFECTS IN COBALAMIN B12 METABOLISM 12 7.85e-01 8.65e-01 0.08480 -0.019800 -0.082500 9.05e-01 6.21e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 8.78e-01 9.21e-01 0.08440 0.069600 0.047800 6.19e-01 7.33e-01
DISEASES OF PROGRAMMED CELL DEATH 54 1.70e-01 3.48e-01 0.08400 0.002310 -0.084000 9.77e-01 2.86e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 4.77e-01 6.52e-01 0.08400 -0.083900 0.001340 4.86e-01 9.91e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 4.85e-01 6.56e-01 0.08380 0.083400 -0.008060 5.19e-01 9.50e-01
SIGNALING BY NODAL 16 9.12e-01 9.44e-01 0.08360 0.059100 0.059100 6.82e-01 6.82e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 7.14e-01 8.18e-01 0.08350 0.016900 0.081800 9.07e-01 5.71e-01
RHO GTPASES ACTIVATE FORMINS 118 2.28e-01 4.15e-01 0.08310 -0.032700 -0.076300 5.39e-01 1.52e-01
PLATELET HOMEOSTASIS 78 5.64e-01 7.17e-01 0.08270 -0.068300 -0.046600 2.97e-01 4.77e-01
RNA POLYMERASE II TRANSCRIPTION 1085 3.72e-05 3.72e-04 0.08270 -0.073200 -0.038500 5.32e-05 3.38e-02
REGULATION OF KIT SIGNALING 16 4.83e-01 6.54e-01 0.08250 -0.026600 0.078100 8.54e-01 5.89e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 2.84e-01 4.72e-01 0.08240 0.030800 0.076400 6.02e-01 1.96e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 7.71e-01 8.60e-01 0.08240 -0.079300 -0.022400 5.95e-01 8.81e-01
SHC1 EVENTS IN ERBB2 SIGNALING 20 3.74e-01 5.57e-01 0.08200 -0.073700 0.036000 5.68e-01 7.80e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 6.22e-01 7.59e-01 0.08110 0.022900 0.077800 8.31e-01 4.68e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 3.59e-01 5.46e-01 0.08080 0.028100 -0.075800 8.16e-01 5.29e-01
HEDGEHOG OFF STATE 107 4.05e-03 2.10e-02 0.08020 0.052000 -0.061100 3.53e-01 2.75e-01
MTOR SIGNALLING 40 8.10e-01 8.78e-01 0.07980 -0.055400 -0.057500 5.45e-01 5.29e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 2.95e-01 4.83e-01 0.07980 0.025000 -0.075800 8.16e-01 4.80e-01
GOLGI TO ER RETROGRADE TRANSPORT 119 4.13e-02 1.31e-01 0.07980 0.079700 0.002420 1.33e-01 9.64e-01
AMINO ACIDS REGULATE MTORC1 51 1.73e-01 3.53e-01 0.07950 0.011000 -0.078700 8.92e-01 3.31e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 4.79e-01 6.54e-01 0.07940 0.073900 0.029100 3.26e-01 7.00e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 1.17e-01 2.69e-01 0.07890 -0.059800 0.051400 4.98e-01 5.60e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 5.37e-01 6.93e-01 0.07850 -0.020100 -0.075900 8.31e-01 4.19e-01
SIGNALING BY MET 75 6.27e-01 7.60e-01 0.07840 0.045700 0.063700 4.94e-01 3.41e-01
RAP1 SIGNALLING 15 6.87e-01 8.01e-01 0.07830 -0.078200 -0.004070 6.00e-01 9.78e-01
DUAL INCISION IN GG NER 40 4.94e-01 6.60e-01 0.07820 -0.017300 -0.076300 8.50e-01 4.04e-01
GENE SILENCING BY RNA 82 4.40e-01 6.21e-01 0.07820 0.033500 0.070600 6.00e-01 2.69e-01
INTERLEUKIN 35 SIGNALLING 10 6.79e-01 7.96e-01 0.07810 -0.075200 0.021100 6.80e-01 9.08e-01
RHOG GTPASE CYCLE 73 6.00e-01 7.46e-01 0.07800 0.042200 0.065600 5.34e-01 3.33e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 6.23e-01 7.59e-01 0.07750 -0.063100 0.044900 7.30e-01 8.06e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 6.23e-01 7.59e-01 0.07750 -0.063100 0.044900 7.30e-01 8.06e-01
PRC2 METHYLATES HISTONES AND DNA 29 5.73e-01 7.20e-01 0.07700 -0.013100 -0.075900 9.03e-01 4.80e-01
NGF STIMULATED TRANSCRIPTION 37 2.24e-01 4.11e-01 0.07690 0.072000 -0.027000 4.48e-01 7.76e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 3.13e-01 5.00e-01 0.07690 -0.020800 -0.074000 7.53e-01 2.62e-01
HCMV LATE EVENTS 65 3.63e-01 5.47e-01 0.07670 0.074100 0.019600 3.02e-01 7.85e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 2.41e-02 8.50e-02 0.07650 -0.008740 -0.076000 8.41e-01 8.16e-02
MRNA CAPPING 29 7.16e-01 8.19e-01 0.07620 -0.027800 -0.070900 7.96e-01 5.09e-01
CARGO CONCENTRATION IN THE ER 30 7.16e-01 8.19e-01 0.07610 0.028600 0.070500 7.86e-01 5.04e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 7.95e-01 8.69e-01 0.07570 0.008660 0.075200 9.60e-01 6.66e-01
G ALPHA Z SIGNALLING EVENTS 45 6.36e-01 7.65e-01 0.07540 -0.030500 -0.069000 7.23e-01 4.23e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 2.87e-01 4.75e-01 0.07520 -0.009840 -0.074500 8.93e-01 3.06e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 16 4.82e-01 6.54e-01 0.07520 -0.054500 0.051700 7.06e-01 7.20e-01
SIGNALING BY FGFR2 62 2.53e-01 4.43e-01 0.07490 -0.005110 -0.074700 9.45e-01 3.09e-01
EPH EPHRIN SIGNALING 92 2.75e-01 4.63e-01 0.07470 0.071800 0.020700 2.35e-01 7.32e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 3.98e-01 5.79e-01 0.07440 0.072400 0.017100 3.36e-01 8.20e-01
SUMOYLATION 161 1.61e-03 1.01e-02 0.07440 -0.067100 0.032100 1.42e-01 4.83e-01
SIGNALING BY VEGF 101 5.70e-01 7.20e-01 0.07430 0.043500 0.060300 4.51e-01 2.95e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 8.65e-01 9.15e-01 0.07380 -0.064100 -0.036600 6.20e-01 7.77e-01
SIGNALING BY FGFR IN DISEASE 55 6.84e-01 8.00e-01 0.07370 -0.063400 -0.037600 4.16e-01 6.30e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 7.36e-01 8.37e-01 0.07350 -0.071200 -0.018300 5.72e-01 8.85e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 6.90e-02 1.88e-01 0.07310 0.051900 -0.051500 4.80e-01 4.83e-01
HYALURONAN UPTAKE AND DEGRADATION 11 6.24e-01 7.59e-01 0.07300 0.047500 -0.055500 7.85e-01 7.50e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 1.78e-01 3.58e-01 0.07280 0.026800 -0.067700 7.50e-01 4.22e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 459 1.35e-01 2.95e-01 0.07280 0.048700 0.054100 7.48e-02 4.77e-02
REGULATION OF SIGNALING BY CBL 22 7.69e-01 8.60e-01 0.07280 -0.023300 -0.068900 8.50e-01 5.76e-01
REGULATION OF FZD BY UBIQUITINATION 19 7.12e-01 8.17e-01 0.07250 -0.010600 -0.071700 9.36e-01 5.88e-01
ERYTHROPOIETIN ACTIVATES RAS 13 9.39e-01 9.60e-01 0.07200 -0.056900 -0.044100 7.22e-01 7.83e-01
NUCLEOTIDE SALVAGE 21 4.16e-01 5.96e-01 0.07200 0.053700 -0.047900 6.70e-01 7.04e-01
EXTENSION OF TELOMERES 49 7.96e-01 8.69e-01 0.07160 -0.044900 -0.055800 5.87e-01 5.00e-01
SIGNALING BY HEDGEHOG 142 2.31e-02 8.23e-02 0.07150 0.071100 -0.007650 1.44e-01 8.75e-01
PTEN REGULATION 134 1.62e-01 3.34e-01 0.07130 -0.017900 -0.069000 7.21e-01 1.68e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 63 7.01e-01 8.09e-01 0.07130 -0.039300 -0.059400 5.90e-01 4.15e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 88 3.86e-02 1.25e-01 0.07100 0.063400 -0.031900 3.04e-01 6.05e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 4.68e-01 6.44e-01 0.07070 -0.025800 0.065800 8.34e-01 5.93e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 7.19e-01 8.22e-01 0.06970 -0.003720 0.069700 9.81e-01 6.52e-01
COPII MEDIATED VESICLE TRANSPORT 64 7.69e-01 8.60e-01 0.06950 0.052100 0.046000 4.71e-01 5.24e-01
BASE EXCISION REPAIR 56 1.76e-01 3.55e-01 0.06920 0.020400 -0.066100 7.92e-01 3.92e-01
FERTILIZATION 12 8.64e-01 9.14e-01 0.06900 -0.018600 -0.066400 9.11e-01 6.90e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 5.65e-01 7.17e-01 0.06890 0.017500 0.066700 8.39e-01 4.39e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 7.33e-01 8.34e-01 0.06870 -0.052600 -0.044200 4.31e-01 5.08e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 9.50e-02 2.34e-01 0.06810 0.060800 -0.030700 3.82e-01 6.60e-01
RESOLUTION OF ABASIC SITES AP SITES 37 5.83e-01 7.28e-01 0.06730 -0.011600 -0.066300 9.03e-01 4.85e-01
INTRAFLAGELLAR TRANSPORT 50 3.49e-01 5.37e-01 0.06730 0.067300 -0.001850 4.11e-01 9.82e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 6.60e-01 7.85e-01 0.06720 0.057500 -0.034800 7.30e-01 8.35e-01
SARS COV INFECTIONS 140 1.68e-02 6.41e-02 0.06700 0.020300 -0.063900 6.79e-01 1.93e-01
SIGNALING BY WNT 268 7.92e-02 2.08e-01 0.06690 -0.022600 -0.063000 5.24e-01 7.65e-02
NUCLEOBASE BIOSYNTHESIS 15 5.83e-01 7.28e-01 0.06690 0.042900 -0.051300 7.73e-01 7.31e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 7.80e-01 8.63e-01 0.06680 0.015800 0.064900 9.02e-01 6.16e-01
RHOJ GTPASE CYCLE 54 4.74e-01 6.50e-01 0.06590 -0.064900 -0.011700 4.10e-01 8.81e-01
DEVELOPMENTAL BIOLOGY 813 5.12e-04 3.65e-03 0.06590 0.062400 0.021100 2.63e-03 3.09e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 23 5.92e-01 7.37e-01 0.06570 0.007590 -0.065200 9.50e-01 5.88e-01
GABA B RECEPTOR ACTIVATION 39 5.06e-01 6.69e-01 0.06560 -0.003560 -0.065500 9.69e-01 4.79e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 8.22e-01 8.85e-01 0.06560 -0.057100 -0.032300 5.65e-01 7.45e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 90 3.35e-01 5.24e-01 0.06540 -0.014800 -0.063700 8.08e-01 2.97e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 9.12e-01 9.44e-01 0.06470 -0.027100 -0.058700 8.66e-01 7.14e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 16 6.31e-01 7.60e-01 0.06420 -0.059500 0.024100 6.80e-01 8.67e-01
RHOD GTPASE CYCLE 50 2.15e-01 4.03e-01 0.06390 -0.055700 0.031200 4.96e-01 7.03e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 20 9.04e-01 9.41e-01 0.06370 -0.054500 -0.032900 6.73e-01 7.99e-01
MAPK FAMILY SIGNALING CASCADES 286 2.52e-01 4.41e-01 0.06360 0.054100 0.033400 1.16e-01 3.33e-01
POTENTIAL THERAPEUTICS FOR SARS 77 1.41e-01 3.01e-01 0.06250 0.059600 -0.018800 3.66e-01 7.75e-01
HIV TRANSCRIPTION ELONGATION 42 2.67e-01 4.55e-01 0.06250 0.046800 -0.041400 6.00e-01 6.42e-01
IRAK1 RECRUITS IKK COMPLEX 14 8.60e-01 9.12e-01 0.06220 0.060400 0.014700 6.96e-01 9.24e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 5.36e-01 6.93e-01 0.06200 -0.060000 0.015700 5.96e-01 8.90e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 1.20e-01 2.74e-01 0.06200 -0.023600 0.057300 7.17e-01 3.79e-01
PLATELET SENSITIZATION BY LDL 15 9.46e-01 9.65e-01 0.06190 -0.037200 -0.049600 8.03e-01 7.40e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 2.40e-01 4.27e-01 0.06180 0.060300 -0.013800 4.12e-01 8.51e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 6.10e-01 7.53e-01 0.06110 0.028500 0.054100 6.39e-01 3.73e-01
ASPARAGINE N LINKED GLYCOSYLATION 282 1.92e-03 1.16e-02 0.06110 0.059500 -0.013700 8.62e-02 6.93e-01
DEUBIQUITINATION 243 4.36e-01 6.16e-01 0.06100 -0.048000 -0.037600 1.98e-01 3.13e-01
BASIGIN INTERACTIONS 23 5.25e-01 6.83e-01 0.06040 0.031600 -0.051500 7.93e-01 6.69e-01
ESR MEDIATED SIGNALING 163 5.75e-01 7.21e-01 0.06020 -0.036700 -0.047700 4.19e-01 2.94e-01
SIGNALING BY NOTCH 189 3.01e-01 4.86e-01 0.05990 0.054900 0.024000 1.94e-01 5.69e-01
DOWNREGULATION OF ERBB2 SIGNALING 27 8.77e-01 9.20e-01 0.05890 0.051700 0.028200 6.42e-01 8.00e-01
NICOTINAMIDE SALVAGING 15 9.54e-01 9.72e-01 0.05870 -0.037100 -0.045500 8.04e-01 7.60e-01
SIALIC ACID METABOLISM 32 6.67e-01 7.91e-01 0.05840 -0.006040 -0.058100 9.53e-01 5.70e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 5.29e-01 6.87e-01 0.05830 0.024300 -0.053000 8.30e-01 6.40e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 8.07e-01 8.78e-01 0.05810 0.006760 -0.057700 9.68e-01 7.29e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 109 3.57e-01 5.45e-01 0.05800 0.056400 0.013400 3.09e-01 8.09e-01
SIGNALING BY ERBB2 47 8.10e-01 8.78e-01 0.05790 -0.050400 -0.028500 5.50e-01 7.35e-01
SIGNALING BY FGFR 72 4.09e-01 5.92e-01 0.05770 -0.005720 -0.057500 9.33e-01 3.99e-01
RNA POLYMERASE I TRANSCRIPTION 67 1.92e-01 3.75e-01 0.05750 0.027000 -0.050800 7.03e-01 4.72e-01
RHOF GTPASE CYCLE 40 4.08e-01 5.92e-01 0.05750 -0.054000 0.019700 5.55e-01 8.30e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 1.52e-01 3.18e-01 0.05740 0.028000 -0.050100 6.74e-01 4.50e-01
CELL CELL JUNCTION ORGANIZATION 50 8.33e-01 8.94e-01 0.05730 -0.047800 -0.031700 5.59e-01 6.99e-01
CLATHRIN MEDIATED ENDOCYTOSIS 130 6.26e-01 7.60e-01 0.05690 0.047500 0.031300 3.50e-01 5.39e-01
DISEASES OF IMMUNE SYSTEM 23 7.56e-01 8.50e-01 0.05670 0.056500 0.005260 6.39e-01 9.65e-01
REGULATION OF TP53 ACTIVITY 151 1.95e-01 3.77e-01 0.05650 0.008110 0.055900 8.64e-01 2.36e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 238 4.57e-01 6.34e-01 0.05590 0.031700 0.046100 4.00e-01 2.22e-01
POLO LIKE KINASE MEDIATED EVENTS 14 7.36e-01 8.37e-01 0.05580 -0.021200 0.051600 8.91e-01 7.38e-01
ACYL CHAIN REMODELLING OF PC 17 9.57e-01 9.73e-01 0.05580 0.041000 0.037900 7.70e-01 7.87e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 7.88e-01 8.66e-01 0.05580 0.054900 0.009890 6.42e-01 9.33e-01
EPHB MEDIATED FORWARD SIGNALING 42 3.56e-01 5.45e-01 0.05570 0.044500 -0.033400 6.18e-01 7.08e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 8.54e-01 9.08e-01 0.05560 -0.055400 0.004930 7.62e-01 9.78e-01
OPIOID SIGNALLING 86 4.53e-01 6.31e-01 0.05530 -0.054200 -0.011200 3.85e-01 8.58e-01
SLC TRANSPORTER DISORDERS 74 2.58e-01 4.45e-01 0.05460 -0.013300 0.053000 8.44e-01 4.31e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 8.20e-01 8.84e-01 0.05450 0.030300 0.045300 6.82e-01 5.41e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.82e-01 6.54e-01 0.05450 0.000450 0.054500 9.95e-01 4.81e-01
SIGNALLING TO ERKS 32 9.24e-01 9.50e-01 0.05450 0.040100 0.036800 6.95e-01 7.18e-01
TRNA PROCESSING IN THE NUCLEUS 56 3.76e-01 5.59e-01 0.05450 -0.011100 0.053300 8.86e-01 4.90e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 8.48e-01 9.04e-01 0.05430 -0.017500 -0.051400 8.80e-01 6.56e-01
NUCLEOTIDE EXCISION REPAIR 109 5.00e-01 6.64e-01 0.05420 -0.018100 -0.051100 7.45e-01 3.57e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 3.50e-01 5.37e-01 0.05340 0.049800 0.019300 2.43e-01 6.52e-01
SIGNAL TRANSDUCTION BY L1 21 8.85e-01 9.26e-01 0.05310 0.049700 0.018800 6.93e-01 8.82e-01
RNA POLYMERASE III TRANSCRIPTION 41 7.51e-01 8.48e-01 0.05300 -0.014900 -0.050800 8.69e-01 5.73e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 7.12e-01 8.17e-01 0.05270 -0.052100 -0.007760 5.88e-01 9.36e-01
SIGNALING BY FGFR4 32 8.43e-01 9.00e-01 0.05260 -0.019700 -0.048800 8.47e-01 6.33e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 8.47e-01 9.04e-01 0.05240 0.025100 0.046000 7.76e-01 6.02e-01
GPVI MEDIATED ACTIVATION CASCADE 31 5.54e-01 7.07e-01 0.05240 0.048600 -0.019400 6.39e-01 8.51e-01
MITOTIC PROPHASE 94 4.15e-01 5.96e-01 0.05100 -0.050600 -0.005920 3.97e-01 9.21e-01
SIGNALING BY NTRK2 TRKB 24 6.55e-01 7.82e-01 0.05080 -0.047600 0.017800 6.86e-01 8.80e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 8.77e-01 9.20e-01 0.05060 0.046800 0.019200 6.74e-01 8.63e-01
NERVOUS SYSTEM DEVELOPMENT 547 6.63e-05 6.43e-04 0.05050 0.046200 -0.020300 6.57e-02 4.19e-01
IRS MEDIATED SIGNALLING 37 7.13e-01 8.17e-01 0.05040 -0.050100 -0.005920 5.98e-01 9.50e-01
LEISHMANIA INFECTION 188 4.53e-01 6.31e-01 0.05020 0.045600 0.021100 2.82e-01 6.19e-01
METABOLISM OF STEROIDS 112 7.89e-01 8.66e-01 0.05010 -0.033300 -0.037400 5.43e-01 4.95e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 4.59e-01 6.34e-01 0.05000 -0.044300 0.023100 6.19e-01 7.95e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 9.06e-01 9.41e-01 0.04990 0.037200 0.033200 6.59e-01 6.94e-01
SNRNP ASSEMBLY 51 6.26e-01 7.60e-01 0.04980 -0.049500 -0.005150 5.41e-01 9.49e-01
HEMOSTASIS 474 5.93e-02 1.70e-01 0.04960 0.047600 0.014000 7.70e-02 6.04e-01
RAC3 GTPASE CYCLE 88 2.29e-01 4.15e-01 0.04900 -0.018700 0.045300 7.62e-01 4.63e-01
CELL JUNCTION ORGANIZATION 74 7.98e-01 8.70e-01 0.04900 0.042200 0.024900 5.31e-01 7.12e-01
HDR THROUGH MMEJ ALT NHEJ 10 8.54e-01 9.08e-01 0.04870 -0.046200 0.015500 8.00e-01 9.32e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 179 1.43e-01 3.05e-01 0.04800 0.048000 -0.001990 2.69e-01 9.63e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 60 5.39e-01 6.94e-01 0.04740 -0.000965 0.047400 9.90e-01 5.26e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 84 2.23e-01 4.11e-01 0.04710 0.033400 -0.033200 5.97e-01 5.99e-01
SIGNALING BY NUCLEAR RECEPTORS 221 4.76e-01 6.51e-01 0.04700 -0.021200 -0.042000 5.88e-01 2.83e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 6.46e-01 7.75e-01 0.04670 -0.045400 -0.011000 5.05e-01 8.71e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 9.38e-01 9.60e-01 0.04610 -0.034200 -0.030900 7.23e-01 7.48e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 5.16e-01 6.77e-01 0.04610 0.019600 -0.041700 8.24e-01 6.37e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 8.76e-01 9.20e-01 0.04510 -0.005310 -0.044800 9.69e-01 7.42e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 41 8.63e-01 9.14e-01 0.04500 0.018200 0.041200 8.40e-01 6.48e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 41 5.18e-01 6.78e-01 0.04480 -0.028200 0.034800 7.55e-01 7.00e-01
REGULATION OF INSULIN SECRETION 71 8.42e-01 9.00e-01 0.04460 0.023400 0.038000 7.34e-01 5.80e-01
HOMOLOGY DIRECTED REPAIR 107 8.35e-01 8.95e-01 0.04440 -0.029200 -0.033400 6.02e-01 5.50e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 7.64e-01 8.57e-01 0.04400 -0.000233 0.044000 9.98e-01 6.72e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 7.75e-01 8.60e-01 0.04390 -0.043900 -0.001180 6.72e-01 9.91e-01
ENDOGENOUS STEROLS 20 8.90e-01 9.29e-01 0.04330 -0.008180 -0.042500 9.50e-01 7.42e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 8.11e-01 8.78e-01 0.04330 0.022600 0.036900 7.08e-01 5.41e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 92 5.33e-01 6.89e-01 0.04320 0.004570 0.042900 9.40e-01 4.77e-01
RAC2 GTPASE CYCLE 86 3.05e-01 4.91e-01 0.04280 -0.021100 0.037300 7.36e-01 5.51e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 6.30e-01 7.60e-01 0.04260 -0.002580 0.042600 9.74e-01 5.96e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 7.62e-01 8.55e-01 0.04230 -0.041400 0.008410 7.15e-01 9.41e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 6.87e-01 8.01e-01 0.04220 -0.020500 0.036800 8.51e-01 7.36e-01
VXPX CARGO TARGETING TO CILIUM 19 7.66e-01 8.59e-01 0.04210 -0.034100 0.024600 7.97e-01 8.53e-01
RAF ACTIVATION 34 9.32e-01 9.56e-01 0.04170 -0.022100 -0.035300 8.23e-01 7.21e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 280 5.69e-01 7.19e-01 0.04160 0.022100 0.035200 5.25e-01 3.12e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 9.76e-01 9.85e-01 0.04140 -0.036300 -0.019800 8.42e-01 9.14e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 9.03e-01 9.41e-01 0.04090 -0.014100 -0.038400 8.95e-01 7.20e-01
CILIUM ASSEMBLY 190 2.42e-01 4.28e-01 0.04090 -0.000317 0.040900 9.94e-01 3.32e-01
GPCR LIGAND BINDING 243 1.46e-01 3.10e-01 0.04080 0.040800 -0.001970 2.74e-01 9.58e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 7.82e-01 8.63e-01 0.04080 0.005840 -0.040400 9.58e-01 7.17e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 9.85e-01 9.92e-01 0.04050 -0.028400 -0.028900 8.71e-01 8.68e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 4.89e-01 6.57e-01 0.03980 0.036600 -0.015700 6.13e-01 8.28e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 9.62e-01 9.75e-01 0.03960 0.017700 0.035400 9.03e-01 8.06e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 9.30e-01 9.55e-01 0.03960 -0.007670 -0.038800 9.59e-01 7.95e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 6.44e-02 1.80e-01 0.03920 0.028200 -0.027300 4.69e-01 4.83e-01
TRANSPORT OF SMALL MOLECULES 569 1.16e-01 2.69e-01 0.03890 0.037500 0.010400 1.28e-01 6.72e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 3.45e-01 5.32e-01 0.03870 -0.027300 0.027500 6.58e-01 6.56e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 5.13e-01 6.75e-01 0.03830 0.010300 0.036900 8.12e-01 3.96e-01
MET RECEPTOR RECYCLING 10 9.35e-01 9.57e-01 0.03730 0.002080 -0.037200 9.91e-01 8.38e-01
MEMBRANE TRAFFICKING 576 4.14e-01 5.96e-01 0.03720 0.031200 0.020200 2.02e-01 4.09e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 8.74e-01 9.20e-01 0.03720 0.032600 -0.017900 8.39e-01 9.11e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 8.55e-01 9.08e-01 0.03690 -0.031700 0.018900 8.32e-01 8.99e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 25 8.76e-01 9.20e-01 0.03640 0.036300 0.002210 7.53e-01 9.85e-01
VESICLE MEDIATED TRANSPORT 604 2.31e-01 4.19e-01 0.03630 0.033600 0.013800 1.60e-01 5.64e-01
METABOLISM OF LIPIDS 609 2.97e-01 4.84e-01 0.03620 0.032400 0.016000 1.73e-01 5.03e-01
TELOMERE EXTENSION BY TELOMERASE 22 9.17e-01 9.47e-01 0.03590 0.007030 0.035200 9.55e-01 7.75e-01
SURFACTANT METABOLISM 17 9.61e-01 9.75e-01 0.03570 0.032800 0.014200 8.15e-01 9.19e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 35 7.04e-01 8.12e-01 0.03520 -0.024200 0.025600 8.05e-01 7.93e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 364 5.09e-01 6.72e-01 0.03470 0.015300 0.031100 6.17e-01 3.10e-01
RHO GTPASE EFFECTORS 245 1.32e-01 2.91e-01 0.03430 0.013900 -0.031400 7.09e-01 3.99e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 9.69e-01 9.80e-01 0.03380 0.018100 0.028600 8.81e-01 8.12e-01
SYNDECAN INTERACTIONS 26 7.93e-01 8.69e-01 0.03370 0.019300 -0.027600 8.65e-01 8.08e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 7.72e-01 8.60e-01 0.03360 0.007170 0.032800 9.13e-01 6.16e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 6.96e-01 8.08e-01 0.03260 0.027400 -0.017700 7.54e-01 8.39e-01
TRANSCRIPTIONAL REGULATION BY TP53 342 7.45e-01 8.44e-01 0.03260 -0.023500 -0.022600 4.57e-01 4.75e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 8.92e-01 9.30e-01 0.03210 0.028600 -0.014600 8.48e-01 9.22e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 9.19e-01 9.47e-01 0.03190 0.001990 -0.031800 9.89e-01 8.20e-01
AURKA ACTIVATION BY TPX2 71 6.97e-01 8.08e-01 0.03160 -0.002920 0.031400 9.66e-01 6.47e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.64e-01 9.77e-01 0.03130 -0.018400 -0.025300 8.47e-01 7.90e-01
SPHINGOLIPID METABOLISM 80 7.70e-01 8.60e-01 0.03080 -0.004300 -0.030500 9.47e-01 6.38e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 9.19e-01 9.47e-01 0.03060 -0.028400 0.011300 8.59e-01 9.44e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 22 8.48e-01 9.04e-01 0.03050 0.020100 -0.022900 8.71e-01 8.52e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 6.01e-01 7.46e-01 0.03030 -0.006520 0.029600 9.13e-01 6.22e-01
TIGHT JUNCTION INTERACTIONS 19 9.65e-01 9.77e-01 0.02980 0.010400 0.028000 9.38e-01 8.33e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 9.76e-01 9.85e-01 0.02900 -0.006160 -0.028300 9.73e-01 8.77e-01
TOLL LIKE RECEPTOR CASCADES 137 9.14e-01 9.45e-01 0.02800 -0.020800 -0.018800 6.74e-01 7.05e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 163 4.88e-01 6.57e-01 0.02710 0.026400 -0.006160 5.62e-01 8.92e-01
CELLULAR RESPONSE TO HEAT STRESS 94 7.45e-01 8.44e-01 0.02640 0.000187 -0.026400 9.97e-01 6.58e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 8.19e-01 8.84e-01 0.02620 0.004210 -0.025800 9.58e-01 7.48e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 9.07e-01 9.41e-01 0.02560 0.022600 0.011900 6.92e-01 8.34e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 9.82e-01 9.90e-01 0.02490 -0.014500 -0.020200 8.93e-01 8.51e-01
NEUROTRANSMITTER RELEASE CYCLE 47 9.21e-01 9.48e-01 0.02470 0.005480 0.024100 9.48e-01 7.75e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 7.84e-01 8.65e-01 0.02470 -0.001780 -0.024600 9.75e-01 6.68e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 8.27e-01 8.90e-01 0.02410 0.004450 -0.023700 9.54e-01 7.58e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.62e-01 9.75e-01 0.02380 0.005930 -0.023100 9.73e-01 8.95e-01
MITOCHONDRIAL BIOGENESIS 92 7.56e-01 8.50e-01 0.02230 0.005350 -0.021700 9.29e-01 7.20e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 57 8.01e-01 8.73e-01 0.02220 0.017900 -0.013100 8.15e-01 8.64e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1213 4.71e-01 6.46e-01 0.02170 -0.010300 -0.019100 5.50e-01 2.68e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.69e-01 9.80e-01 0.02120 -0.006000 0.020300 9.73e-01 9.07e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 282 6.31e-01 7.60e-01 0.02060 0.001550 0.020500 9.64e-01 5.53e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.09e-01 9.42e-01 0.02010 -0.019500 -0.004700 7.56e-01 9.40e-01
FLT3 SIGNALING 37 9.89e-01 9.92e-01 0.01890 -0.014300 -0.012400 8.80e-01 8.96e-01
SENSORY PERCEPTION 148 9.16e-01 9.47e-01 0.01860 0.017000 0.007730 7.22e-01 8.71e-01
UNWINDING OF DNA 12 9.94e-01 9.95e-01 0.01850 0.016200 0.008970 9.22e-01 9.57e-01
VISUAL PHOTOTRANSDUCTION 60 9.54e-01 9.72e-01 0.01750 0.016800 0.004730 8.22e-01 9.50e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 9.39e-01 9.60e-01 0.01720 0.008280 -0.015100 9.40e-01 8.90e-01
SIGNALING BY FGFR3 35 9.41e-01 9.61e-01 0.01580 0.005820 -0.014700 9.52e-01 8.80e-01
G ALPHA Q SIGNALLING EVENTS 145 7.96e-01 8.69e-01 0.01560 -0.014800 0.004730 7.58e-01 9.22e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 29 9.59e-01 9.75e-01 0.01550 0.003260 -0.015100 9.76e-01 8.88e-01
DNA REPAIR 291 7.52e-01 8.48e-01 0.01520 -0.015200 -0.000304 6.56e-01 9.93e-01
G ALPHA I SIGNALLING EVENTS 189 8.07e-01 8.78e-01 0.01520 0.001060 -0.015100 9.80e-01 7.20e-01
MEIOTIC SYNAPSIS 39 9.92e-01 9.95e-01 0.01510 -0.009550 -0.011700 9.18e-01 8.99e-01
ACYL CHAIN REMODELLING OF PE 16 9.86e-01 9.92e-01 0.01460 -0.000767 -0.014600 9.96e-01 9.20e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 90 9.27e-01 9.52e-01 0.01420 -0.000497 -0.014200 9.93e-01 8.16e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 9.95e-01 9.95e-01 0.01040 -0.008510 -0.005930 9.19e-01 9.43e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.88e-01 9.92e-01 0.00999 0.009890 -0.001410 9.35e-01 9.91e-01
DNA DOUBLE STRAND BREAK REPAIR 136 9.88e-01 9.92e-01 0.00885 -0.007460 -0.004770 8.81e-01 9.24e-01
TRNA PROCESSING 105 9.99e-01 9.99e-01 0.00227 0.001130 0.001970 9.84e-01 9.72e-01


Detailed Gene set reports


SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
metric value
setSize 12
pMANOVA 0.000471
p.adjustMANOVA 0.00344
s.dist 0.841
s.LPS -0.531
s.OVA -0.653
p.LPS 0.00146
p.OVA 9.07e-05



Top 20 genes
Gene LPS OVA
Spcs2 -8004 -8233
Spcs3 -7866 -7690
Dpp4 -7067 -7785
Pcsk1 -7251 -6383
Spcs1 -5579 -6579
Sec11a -3693 -6347
Sec11c -3674 -5158
Tcf7l2 -2871 -3805
Pax6 -1818 -3326
Grp -1310 -4579
Ctnnb1 -2284 -2544

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All member genes
LPS OVA
Ctnnb1 -2284 -2544
Dpp4 -7067 -7785
Gng13 874 -2150
Grp -1310 -4579
Pax6 -1818 -3326
Pcsk1 -7251 -6383
Sec11a -3693 -6347
Sec11c -3674 -5158
Spcs1 -5579 -6579
Spcs2 -8004 -8233
Spcs3 -7866 -7690
Tcf7l2 -2871 -3805



INCRETIN SYNTHESIS SECRETION AND INACTIVATION
INCRETIN SYNTHESIS SECRETION AND INACTIVATION
metric value
setSize 13
pMANOVA 0.000292
p.adjustMANOVA 0.00225
s.dist 0.828
s.LPS -0.518
s.OVA -0.646
p.LPS 0.00123
p.OVA 5.49e-05



Top 20 genes
Gene LPS OVA
Spcs2 -8004 -8233
Spcs3 -7866 -7690
Dpp4 -7067 -7785
Pcsk1 -7251 -6383
Spcs1 -5579 -6579
Sec11a -3693 -6347
Sec11c -3674 -5158
Isl1 -2780 -4674
Tcf7l2 -2871 -3805
Pax6 -1818 -3326
Grp -1310 -4579
Ctnnb1 -2284 -2544

Click HERE to show all gene set members

All member genes
LPS OVA
Ctnnb1 -2284 -2544
Dpp4 -7067 -7785
Gng13 874 -2150
Grp -1310 -4579
Isl1 -2780 -4674
Pax6 -1818 -3326
Pcsk1 -7251 -6383
Sec11a -3693 -6347
Sec11c -3674 -5158
Spcs1 -5579 -6579
Spcs2 -8004 -8233
Spcs3 -7866 -7690
Tcf7l2 -2871 -3805



SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
metric value
setSize 12
pMANOVA 0.00656
p.adjustMANOVA 0.031
s.dist 0.696
s.LPS -0.455
s.OVA -0.527
p.LPS 0.00639
p.OVA 0.00158



Top 20 genes
Gene LPS OVA
Spcs2 -8004 -8233
Spcs3 -7866 -7690
Pla2g7 -7286 -8142
Pcsk1 -7251 -6383
Spcs1 -5579 -6579
Bche -6162 -5705
Igf1 -6896 -3487
Sec11a -3693 -6347
Sec11c -3674 -5158

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All member genes
LPS OVA
Ache 7277 4407
Bche -6162 -5705
Crhr2 3226 3702
Igf1 -6896 -3487
Klf4 3015 -2292
Pcsk1 -7251 -6383
Pla2g7 -7286 -8142
Sec11a -3693 -6347
Sec11c -3674 -5158
Spcs1 -5579 -6579
Spcs2 -8004 -8233
Spcs3 -7866 -7690



ADENYLATE CYCLASE ACTIVATING PATHWAY
ADENYLATE CYCLASE ACTIVATING PATHWAY
metric value
setSize 10
pMANOVA 0.0172
p.adjustMANOVA 0.0653
s.dist 0.694
s.LPS 0.467
s.OVA 0.514
p.LPS 0.0105
p.OVA 0.00489



Top 20 genes
Gene LPS OVA
Adcy6 7848 8265
Adcy4 7447 7483
Adcy1 6228 7798
Adcy5 7195 6034
Adcy3 6165 6201
Adcy9 3748 5937
Gnal 2340 1938
Adcy7 496 5702

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All member genes
LPS OVA
Adcy1 6228 7798
Adcy2 1741 -1351
Adcy3 6165 6201
Adcy4 7447 7483
Adcy5 7195 6034
Adcy6 7848 8265
Adcy7 496 5702
Adcy8 -1544 -3877
Adcy9 3748 5937
Gnal 2340 1938



APOPTOSIS INDUCED DNA FRAGMENTATION
APOPTOSIS INDUCED DNA FRAGMENTATION
metric value
setSize 10
pMANOVA 0.0225
p.adjustMANOVA 0.0806
s.dist 0.678
s.LPS -0.482
s.OVA -0.477
p.LPS 0.00832
p.OVA 0.00907



Top 20 genes
Gene LPS OVA
Hmgb1 -7984 -8175
H1f2 -7845 -8289
H1f0 -7402 -8125
Casp3 -7217 -8208
Hmgb2 -5352 -7829
Kpna1 -7596 -5403
H1f4 -5922 -5762

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All member genes
LPS OVA
Casp3 -7217 -8208
Dffa 7116 5922
Dffb 6007 5621
H1f0 -7402 -8125
H1f2 -7845 -8289
H1f4 -5922 -5762
Hmgb1 -7984 -8175
Hmgb2 -5352 -7829
Kpna1 -7596 -5403
Kpnb1 -1841 1205



TERMINATION OF O GLYCAN BIOSYNTHESIS
TERMINATION OF O GLYCAN BIOSYNTHESIS
metric value
setSize 10
pMANOVA 0.0215
p.adjustMANOVA 0.0781
s.dist 0.676
s.LPS 0.499
s.OVA 0.456
p.LPS 0.00631
p.OVA 0.0125



Top 20 genes
Gene LPS OVA
St3gal3 8596 7891
St6galnac4 7850 4963
St3gal2 7040 5096
St3gal1 4018 7101
St6galnac2 5683 4987
Muc3a 3664 5081
St6galnac3 3343 3372
Muc6 4006 2047

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All member genes
LPS OVA
Muc3a 3664 5081
Muc6 4006 2047
St3gal1 4018 7101
St3gal2 7040 5096
St3gal3 8596 7891
St3gal4 2130 -436
St6gal1 -2005 -838
St6galnac2 5683 4987
St6galnac3 3343 3372
St6galnac4 7850 4963



CD28 DEPENDENT VAV1 PATHWAY
CD28 DEPENDENT VAV1 PATHWAY
metric value
setSize 11
pMANOVA 0.0181
p.adjustMANOVA 0.0682
s.dist 0.656
s.LPS -0.439
s.OVA -0.488
p.LPS 0.0117
p.OVA 0.00507



Top 20 genes
Gene LPS OVA
Cdc42 -8072 -8187
Pak1 -6863 -8066
Pak3 -7891 -6807
Pak2 -6919 -4956
Rac1 -4941 -5758
Cd86 -3441 -4969
Cd80 -2931 -2853
Grb2 -1143 -2755

Click HERE to show all gene set members

All member genes
LPS OVA
Cd80 -2931 -2853
Cd86 -3441 -4969
Cdc42 -8072 -8187
Fyn 1063 991
Grb2 -1143 -2755
Lck 1370 -1777
Pak1 -6863 -8066
Pak2 -6919 -4956
Pak3 -7891 -6807
Rac1 -4941 -5758
Vav1 1899 1135



CROSSLINKING OF COLLAGEN FIBRILS
CROSSLINKING OF COLLAGEN FIBRILS
metric value
setSize 15
pMANOVA 0.00417
p.adjustMANOVA 0.0213
s.dist 0.639
s.LPS 0.494
s.OVA 0.406
p.LPS 0.000932
p.OVA 0.00643



Top 20 genes
Gene LPS OVA
Pxdn 7331 8346
Loxl3 7648 7427
Col4a2 6179 6210
Loxl1 8248 4172
Col4a1 5567 5828
Col4a3 3773 7474
Bmp1 5175 4542
Col4a5 4193 5169
Tll2 4692 2629
Col1a1 6154 1840
Col4a4 2343 4535
Pcolce 7301 66

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All member genes
LPS OVA
Bmp1 5175 4542
Col1a1 6154 1840
Col1a2 2458 -2665
Col4a1 5567 5828
Col4a2 6179 6210
Col4a3 3773 7474
Col4a4 2343 4535
Col4a5 4193 5169
Loxl1 8248 4172
Loxl2 -2778 -1036
Loxl3 7648 7427
Pcolce 7301 66
Pxdn 7331 8346
Tll1 -2465 -1902
Tll2 4692 2629



SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
metric value
setSize 29
pMANOVA 2.16e-05
p.adjustMANOVA 0.000227
s.dist 0.639
s.LPS -0.402
s.OVA -0.497
p.LPS 0.00018
p.OVA 3.56e-06



Top 20 genes
Gene LPS OVA
Ube2e1 -7960 -8024
Ube2b -7680 -8117
Ube2d1 -7737 -8050
Ube2k -8002 -7745
Ube2l3 -7417 -8057
Ube2w -7938 -7440
Ube2d2a -6981 -8073
Ube2e3 -7436 -7422
Ube2g1 -7671 -7058
Ube2a -6992 -7589
Ube2q2 -7812 -6618
Ube2r2 -4348 -7335
Uchl3 -5105 -6158
Rps27a -4152 -6449
Ube2t -2639 -7100
Uba6 -6161 -2842
Usp9x -7161 -2078
Otulin -3286 -3770
Usp7 -3132 -407

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All member genes
LPS OVA
Cdc34 2936 -1517
Otulin -3286 -3770
Rps27a -4152 -6449
Uba1 3163 2271
Uba52 1246 -3924
Uba6 -6161 -2842
Ubb 5594 -1688
Ubc 4950 173
Ube2a -6992 -7589
Ube2b -7680 -8117
Ube2d1 -7737 -8050
Ube2d2a -6981 -8073
Ube2e1 -7960 -8024
Ube2e3 -7436 -7422
Ube2g1 -7671 -7058
Ube2g2 6342 5627
Ube2h -2979 1773
Ube2k -8002 -7745
Ube2l3 -7417 -8057
Ube2q2 -7812 -6618
Ube2r2 -4348 -7335
Ube2s 509 -3328
Ube2t -2639 -7100
Ube2w -7938 -7440
Ube2z 2306 983
Uchl3 -5105 -6158
Usp5 4834 1822
Usp7 -3132 -407
Usp9x -7161 -2078



GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
metric value
setSize 31
pMANOVA 2.29e-08
p.adjustMANOVA 4.87e-07
s.dist 0.627
s.LPS -0.295
s.OVA -0.554
p.LPS 0.00446
p.OVA 9.54e-08



Top 20 genes
Gene LPS OVA
Cdc42 -8072 -8187
Tcp1 -7625 -8207
Rap1b -7860 -7822
Hnrnpdl -6740 -7875
Pdcd4 -7511 -6939
Hnrnpa2b1 -7016 -7329
Rala -6904 -7386
Hspa9 -6632 -7413
Ppia -4874 -7796
Capza1 -6508 -5750
Pak2 -6919 -4956
Mtap -3885 -6771
Rplp0 -2962 -8016
Sod2 -6105 -3719
Psme2 -3440 -6537
Hnrnpf -4213 -4631
Snrpa1 -3604 -5179
Lcp1 -2725 -5801
Pitpna -2645 -1681
Gsto1 -780 -5500

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All member genes
LPS OVA
Aip 4002 -2593
Anxa2 5322 502
Arf1 2086 -557
Bola2 4081 -8
Capza1 -6508 -5750
Cdc42 -8072 -8187
Cfl1 4853 -2988
Cnn2 51 -4978
Gsto1 -780 -5500
Hnrnpa2b1 -7016 -7329
Hnrnpdl -6740 -7875
Hnrnpf -4213 -4631
Hspa9 -6632 -7413
Lcp1 -2725 -5801
Lmnb1 2926 1453
Mif 7927 3962
Msn -493 -1247
Mtap -3885 -6771
Pak2 -6919 -4956
Pdcd4 -7511 -6939
Pitpna -2645 -1681
Ppia -4874 -7796
Psme2 -3440 -6537
Rala -6904 -7386
Rap1b -7860 -7822
Rplp0 -2962 -8016
Snrpa1 -3604 -5179
Sod1 3521 -3185
Sod2 -6105 -3719
Taldo1 3563 -3777
Tcp1 -7625 -8207



PROCESSING AND ACTIVATION OF SUMO
PROCESSING AND ACTIVATION OF SUMO
metric value
setSize 10
pMANOVA 0.0295
p.adjustMANOVA 0.1
s.dist 0.598
s.LPS -0.481
s.OVA -0.356
p.LPS 0.00847
p.OVA 0.0514



Top 20 genes
Gene LPS OVA
Sumo2 -7594 -8115
Sumo1 -7691 -7608
Rwdd3 -6478 -4336
Ube2i -5430 -1977
Sumo3 -1632 -4749
Uba2 -3120 -2238
Sae1 -1002 -5692
Senp5 -4298 -144

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All member genes
LPS OVA
Rwdd3 -6478 -4336
Sae1 -1002 -5692
Senp1 2848 3835
Senp2 -3543 2124
Senp5 -4298 -144
Sumo1 -7691 -7608
Sumo2 -7594 -8115
Sumo3 -1632 -4749
Uba2 -3120 -2238
Ube2i -5430 -1977



ACTIVATION OF SMO
ACTIVATION OF SMO
metric value
setSize 16
pMANOVA 0.00909
p.adjustMANOVA 0.0398
s.dist 0.594
s.LPS 0.432
s.OVA 0.408
p.LPS 0.00277
p.OVA 0.0047



Top 20 genes
Gene LPS OVA
Arrb2 8346 7961
Evc2 8120 7590
Smo 7755 7578
Boc 6722 6896
Iqce 6878 6614
Gas8 6954 5766
Evc 7316 5192
Grk2 7608 4989
Arrb1 4509 5196
Cdon 2796 5943
Gas1 6429 1436
Ptch1 1767 4885

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All member genes
LPS OVA
Arrb1 4509 5196
Arrb2 8346 7961
Boc 6722 6896
Cdon 2796 5943
Csnk1a1 -6611 -2303
Efcab7 -5223 -5615
Evc 7316 5192
Evc2 8120 7590
Gas1 6429 1436
Gas8 6954 5766
Grk2 7608 4989
Iqce 6878 6614
Kif3a -1360 -2280
Ptch1 1767 4885
Shh -83 -3464
Smo 7755 7578



ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
metric value
setSize 59
pMANOVA 3.92e-19
p.adjustMANOVA 2.29e-17
s.dist 0.59
s.LPS -0.207
s.OVA -0.552
p.LPS 0.00593
p.OVA 2.21e-13



Top 20 genes
Gene LPS OVA
Rps18 -8130 -8305
Eif4a2 -8151 -8223
Eif3j2 -7973 -8156
Eif2s2 -7829 -8273
Eif3e -7918 -8152
Eif4e -7931 -8106
Eif2s1 -7855 -8029
Rps7 -7427 -8293
Eif3m -7112 -7953
Eif1ax -7995 -6667
Rps2 -6489 -7719
Eif2s3x -7526 -6601
Rps3a1 -4715 -7198
Eif4b -5661 -5710
Rps4x -4467 -7052
Rps24 -4143 -7542
Pabpc1 -4249 -7278
Eif3a -4922 -5964
Rps27a -4152 -6449
Rps3 -3360 -6572

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7995 -6667
Eif2s1 -7855 -8029
Eif2s2 -7829 -8273
Eif2s3x -7526 -6601
Eif3a -4922 -5964
Eif3b 5881 3022
Eif3c 3371 -2690
Eif3d 3257 -2320
Eif3e -7918 -8152
Eif3f 3238 -1728
Eif3g -209 -5268
Eif3h -2200 -7077
Eif3i 4162 281
Eif3j1 -3807 -4108
Eif3j2 -7973 -8156
Eif3k 3184 -2407
Eif3l 5086 2368
Eif3m -7112 -7953
Eif4a1 -396 -4169
Eif4a2 -8151 -8223
Eif4b -5661 -5710
Eif4e -7931 -8106
Eif4ebp1 902 -3331
Eif4g1 4140 3925
Eif4h 4066 1576
Fau 2623 -3236
Pabpc1 -4249 -7278
Rps10 1539 -4276
Rps11 539 -4479
Rps12 3922 -1797
Rps13 -3079 -6003
Rps14 -1149 -6094
Rps15 2982 -2178
Rps15a -263 -3338
Rps16 -1650 -5139
Rps17 356 -3811
Rps18 -8130 -8305
Rps19 -305 -4696
Rps2 -6489 -7719
Rps20 789 -5037
Rps21 1676 -1411
Rps23 -2520 -6494
Rps24 -4143 -7542
Rps25 -1837 -5672
Rps26 726 -3828
Rps27 257 -3604
Rps27a -4152 -6449
Rps27l -3638 -5928
Rps28 4824 2401
Rps29 5538 3961
Rps3 -3360 -6572
Rps3a1 -4715 -7198
Rps4x -4467 -7052
Rps5 2417 -3011
Rps6 -2214 -6731
Rps7 -7427 -8293
Rps8 -2386 -6535
Rps9 -1061 -5313
Rpsa 1252 -4511



EUKARYOTIC TRANSLATION ELONGATION
EUKARYOTIC TRANSLATION ELONGATION
metric value
setSize 87
pMANOVA 1.03e-38
p.adjustMANOVA 4.01e-36
s.dist 0.587
s.LPS -0.128
s.OVA -0.573
p.LPS 0.0395
p.OVA 2.34e-20



Top 20 genes
Gene LPS OVA
Rps18 -8130 -8305
Rps7 -7427 -8293
Rpl22l1 -7572 -8091
Rpl35a -7117 -8275
Rpl30 -6708 -8242
Rpl5 -6829 -7990
Rps2 -6489 -7719
Eef1g -5451 -7598
Rpl3 -5307 -7374
Rpl27a -4838 -7757
Rps3a1 -4715 -7198
Rpl15 -4649 -7096
Rpl29 -4311 -7541
Rpl24 -4860 -6684
Rps4x -4467 -7052
Rps24 -4143 -7542
Rpl6 -4397 -6938
Rpl26 -4006 -7479
Rps27a -4152 -6449
Rpl36a -3374 -7575

Click HERE to show all gene set members

All member genes
LPS OVA
Eef1a1 -437 -5727
Eef1a2 4945 -995
Eef1b2 -2895 -6753
Eef1d 4917 -1533
Eef1g -5451 -7598
Eef2 5949 -743
Fau 2623 -3236
Rpl10 2426 507
Rpl10a 991 -4760
Rpl11 -2506 -6268
Rpl12 3958 942
Rpl13 3378 -1929
Rpl13a -2548 -6500
Rpl14 -3852 -6216
Rpl15 -4649 -7096
Rpl17 -3129 -6498
Rpl18 2997 -2908
Rpl18a 305 -5495
Rpl19 1011 -3677
Rpl21 1147 -4968
Rpl22 -4098 -6121
Rpl22l1 -7572 -8091
Rpl23 -2535 -5397
Rpl23a -430 -5509
Rpl24 -4860 -6684
Rpl26 -4006 -7479
Rpl27 -286 -4951
Rpl27a -4838 -7757
Rpl28 1738 -3913
Rpl29 -4311 -7541
Rpl3 -5307 -7374
Rpl30 -6708 -8242
Rpl31 108 -5142
Rpl32 552 -3621
Rpl34 2273 -2980
Rpl35 1205 -1839
Rpl35a -7117 -8275
Rpl36 4588 -161
Rpl36a -3374 -7575
Rpl36al 1237 -4876
Rpl37 3846 143
Rpl37a 2792 -3065
Rpl38 4256 1285
Rpl39 520 -2708
Rpl4 -3203 -6176
Rpl5 -6829 -7990
Rpl6 -4397 -6938
Rpl7 -3882 -6566
Rpl7a 1582 -4324
Rpl8 2867 -2597
Rpl9 -3189 -6717
Rplp0 -2962 -8016
Rplp1 2429 -2664
Rplp2 3911 -423
Rps10 1539 -4276
Rps11 539 -4479
Rps12 3922 -1797
Rps13 -3079 -6003
Rps14 -1149 -6094
Rps15 2982 -2178
Rps15a -263 -3338
Rps16 -1650 -5139
Rps17 356 -3811
Rps18 -8130 -8305
Rps19 -305 -4696
Rps2 -6489 -7719
Rps20 789 -5037
Rps21 1676 -1411
Rps23 -2520 -6494
Rps24 -4143 -7542
Rps25 -1837 -5672
Rps26 726 -3828
Rps27 257 -3604
Rps27a -4152 -6449
Rps27l -3638 -5928
Rps28 4824 2401
Rps29 5538 3961
Rps3 -3360 -6572
Rps3a1 -4715 -7198
Rps4x -4467 -7052
Rps5 2417 -3011
Rps6 -2214 -6731
Rps7 -7427 -8293
Rps8 -2386 -6535
Rps9 -1061 -5313
Rpsa 1252 -4511
Uba52 1246 -3924



CRMPS IN SEMA3A SIGNALING
CRMPS IN SEMA3A SIGNALING
metric value
setSize 16
pMANOVA 0.00212
p.adjustMANOVA 0.0125
s.dist 0.585
s.LPS 0.321
s.OVA 0.489
p.LPS 0.0262
p.OVA 0.00071



Top 20 genes
Gene LPS OVA
Dpysl5 7611 8353
Plxna3 8054 7850
Dpysl4 8232 7530
Plxna1 7410 8164
Fes 7785 7172
Crmp1 7100 6081
Plxna4 4596 6884
Nrp1 3783 5962
Plxna2 2439 6914
Cdk5 6382 2548
Fyn 1063 991

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk5 6382 2548
Cdk5r1 -2861 -299
Crmp1 7100 6081
Dpysl2 -161 2840
Dpysl3 -3246 -1612
Dpysl4 8232 7530
Dpysl5 7611 8353
Fes 7785 7172
Fyn 1063 991
Gsk3b -5313 -134
Nrp1 3783 5962
Plxna1 7410 8164
Plxna2 2439 6914
Plxna3 8054 7850
Plxna4 4596 6884
Sema3a -5853 -2019



CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
metric value
setSize 13
pMANOVA 0.0205
p.adjustMANOVA 0.0756
s.dist 0.583
s.LPS 0.446
s.OVA 0.376
p.LPS 0.00534
p.OVA 0.0191



Top 20 genes
Gene LPS OVA
Ercc2 8598 7718
Mms19 7658 7761
Nubp1 7693 6686
Ndor1 6325 7035
Ciao3 7554 5680
Rtel1 5316 6275
Pold1 6012 4496
Ciapin1 4370 3805
Ciao2b 3896 106
Ciao1 1932 140

Click HERE to show all gene set members

All member genes
LPS OVA
Abcb7 -7668 -5146
Brip1 -4758 -2173
Ciao1 1932 140
Ciao2b 3896 106
Ciao3 7554 5680
Ciapin1 4370 3805
Ercc2 8598 7718
Mms19 7658 7761
Ndor1 6325 7035
Nubp1 7693 6686
Nubp2 4943 -123
Pold1 6012 4496
Rtel1 5316 6275



SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
metric value
setSize 14
pMANOVA 0.015
p.adjustMANOVA 0.0592
s.dist 0.578
s.LPS 0.365
s.OVA 0.447
p.LPS 0.0179
p.OVA 0.00376



Top 20 genes
Gene LPS OVA
Plxna3 8054 7850
Plxna1 7410 8164
Tln1 8298 7198
Fes 7785 7172
Pip5k1c 7431 6780
Plxna4 4596 6884
Nrp1 3783 5962
Plxna2 2439 6914
Farp2 1706 4866
Rras 4440 1689
Fyn 1063 991

Click HERE to show all gene set members

All member genes
LPS OVA
Farp2 1706 4866
Fes 7785 7172
Fyn 1063 991
Nrp1 3783 5962
Pip5k1c 7431 6780
Plxna1 7410 8164
Plxna2 2439 6914
Plxna3 8054 7850
Plxna4 4596 6884
Rac1 -4941 -5758
Rnd1 145 -2759
Rras 4440 1689
Sema3a -5853 -2019
Tln1 8298 7198



EUKARYOTIC TRANSLATION INITIATION
EUKARYOTIC TRANSLATION INITIATION
metric value
setSize 114
pMANOVA 3.7e-40
p.adjustMANOVA 2.16e-37
s.dist 0.573
s.LPS -0.168
s.OVA -0.548
p.LPS 0.00202
p.OVA 4.69e-24



Top 20 genes
Gene LPS OVA
Rps18 -8130 -8305
Eif4a2 -8151 -8223
Eif5 -8119 -8163
Eif3j2 -7973 -8156
Eif2s2 -7829 -8273
Eif3e -7918 -8152
Eif4e -7931 -8106
Eif2s1 -7855 -8029
Eif5b -7557 -8246
Rps7 -7427 -8293
Rpl22l1 -7572 -8091
Rpl35a -7117 -8275
Eif3m -7112 -7953
Rpl30 -6708 -8242
Rpl5 -6829 -7990
Eif1ax -7995 -6667
Rps2 -6489 -7719
Eif2s3x -7526 -6601
Rpl3 -5307 -7374
Rpl27a -4838 -7757

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7995 -6667
Eif2b1 3113 2527
Eif2b2 7727 6783
Eif2b3 -4489 -6798
Eif2b4 5927 2100
Eif2b5 4974 -2553
Eif2s1 -7855 -8029
Eif2s2 -7829 -8273
Eif2s3x -7526 -6601
Eif3a -4922 -5964
Eif3b 5881 3022
Eif3c 3371 -2690
Eif3d 3257 -2320
Eif3e -7918 -8152
Eif3f 3238 -1728
Eif3g -209 -5268
Eif3h -2200 -7077
Eif3i 4162 281
Eif3j1 -3807 -4108
Eif3j2 -7973 -8156
Eif3k 3184 -2407
Eif3l 5086 2368
Eif3m -7112 -7953
Eif4a1 -396 -4169
Eif4a2 -8151 -8223
Eif4b -5661 -5710
Eif4e -7931 -8106
Eif4ebp1 902 -3331
Eif4g1 4140 3925
Eif4h 4066 1576
Eif5 -8119 -8163
Eif5b -7557 -8246
Fau 2623 -3236
Pabpc1 -4249 -7278
Rpl10 2426 507
Rpl10a 991 -4760
Rpl11 -2506 -6268
Rpl12 3958 942
Rpl13 3378 -1929
Rpl13a -2548 -6500
Rpl14 -3852 -6216
Rpl15 -4649 -7096
Rpl17 -3129 -6498
Rpl18 2997 -2908
Rpl18a 305 -5495
Rpl19 1011 -3677
Rpl21 1147 -4968
Rpl22 -4098 -6121
Rpl22l1 -7572 -8091
Rpl23 -2535 -5397
Rpl23a -430 -5509
Rpl24 -4860 -6684
Rpl26 -4006 -7479
Rpl27 -286 -4951
Rpl27a -4838 -7757
Rpl28 1738 -3913
Rpl29 -4311 -7541
Rpl3 -5307 -7374
Rpl30 -6708 -8242
Rpl31 108 -5142
Rpl32 552 -3621
Rpl34 2273 -2980
Rpl35 1205 -1839
Rpl35a -7117 -8275
Rpl36 4588 -161
Rpl36a -3374 -7575
Rpl36al 1237 -4876
Rpl37 3846 143
Rpl37a 2792 -3065
Rpl38 4256 1285
Rpl39 520 -2708
Rpl4 -3203 -6176
Rpl5 -6829 -7990
Rpl6 -4397 -6938
Rpl7 -3882 -6566
Rpl7a 1582 -4324
Rpl8 2867 -2597
Rpl9 -3189 -6717
Rplp0 -2962 -8016
Rplp1 2429 -2664
Rplp2 3911 -423
Rps10 1539 -4276
Rps11 539 -4479
Rps12 3922 -1797
Rps13 -3079 -6003
Rps14 -1149 -6094
Rps15 2982 -2178
Rps15a -263 -3338
Rps16 -1650 -5139
Rps17 356 -3811
Rps18 -8130 -8305
Rps19 -305 -4696
Rps2 -6489 -7719
Rps20 789 -5037
Rps21 1676 -1411
Rps23 -2520 -6494
Rps24 -4143 -7542
Rps25 -1837 -5672
Rps26 726 -3828
Rps27 257 -3604
Rps27a -4152 -6449
Rps27l -3638 -5928
Rps28 4824 2401
Rps29 5538 3961
Rps3 -3360 -6572
Rps3a1 -4715 -7198
Rps4x -4467 -7052
Rps5 2417 -3011
Rps6 -2214 -6731
Rps7 -7427 -8293
Rps8 -2386 -6535
Rps9 -1061 -5313
Rpsa 1252 -4511
Uba52 1246 -3924



SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
metric value
setSize 106
pMANOVA 1.51e-35
p.adjustMANOVA 3.53e-33
s.dist 0.568
s.LPS -0.173
s.OVA -0.541
p.LPS 0.00208
p.OVA 6.18e-22



Top 20 genes
Gene LPS OVA
Rps18 -8130 -8305
Spcs2 -8004 -8233
Rps7 -7427 -8293
Rpl22l1 -7572 -8091
Spcs3 -7866 -7690
Srp54a -7592 -7830
Rpl35a -7117 -8275
Ssr1 -7954 -7118
Ssr3 -7794 -7264
Rpl30 -6708 -8242
Rpl5 -6829 -7990
Rps2 -6489 -7719
Srp19 -5667 -7557
Sec61g -6202 -6700
Rpl3 -5307 -7374
Rpl27a -4838 -7757
Spcs1 -5579 -6579
Rps3a1 -4715 -7198
Rpl15 -4649 -7096
Rpl29 -4311 -7541

Click HERE to show all gene set members

All member genes
LPS OVA
Ddost 3977 189
Fau 2623 -3236
Rpl10 2426 507
Rpl10a 991 -4760
Rpl11 -2506 -6268
Rpl12 3958 942
Rpl13 3378 -1929
Rpl13a -2548 -6500
Rpl14 -3852 -6216
Rpl15 -4649 -7096
Rpl17 -3129 -6498
Rpl18 2997 -2908
Rpl18a 305 -5495
Rpl19 1011 -3677
Rpl21 1147 -4968
Rpl22 -4098 -6121
Rpl22l1 -7572 -8091
Rpl23 -2535 -5397
Rpl23a -430 -5509
Rpl24 -4860 -6684
Rpl26 -4006 -7479
Rpl27 -286 -4951
Rpl27a -4838 -7757
Rpl28 1738 -3913
Rpl29 -4311 -7541
Rpl3 -5307 -7374
Rpl30 -6708 -8242
Rpl31 108 -5142
Rpl32 552 -3621
Rpl34 2273 -2980
Rpl35 1205 -1839
Rpl35a -7117 -8275
Rpl36 4588 -161
Rpl36a -3374 -7575
Rpl36al 1237 -4876
Rpl37 3846 143
Rpl37a 2792 -3065
Rpl38 4256 1285
Rpl39 520 -2708
Rpl4 -3203 -6176
Rpl5 -6829 -7990
Rpl6 -4397 -6938
Rpl7 -3882 -6566
Rpl7a 1582 -4324
Rpl8 2867 -2597
Rpl9 -3189 -6717
Rplp0 -2962 -8016
Rplp1 2429 -2664
Rplp2 3911 -423
Rpn1 1261 -4154
Rpn2 4494 -241
Rps10 1539 -4276
Rps11 539 -4479
Rps12 3922 -1797
Rps13 -3079 -6003
Rps14 -1149 -6094
Rps15 2982 -2178
Rps15a -263 -3338
Rps16 -1650 -5139
Rps17 356 -3811
Rps18 -8130 -8305
Rps19 -305 -4696
Rps2 -6489 -7719
Rps20 789 -5037
Rps21 1676 -1411
Rps23 -2520 -6494
Rps24 -4143 -7542
Rps25 -1837 -5672
Rps26 726 -3828
Rps27 257 -3604
Rps27a -4152 -6449
Rps27l -3638 -5928
Rps28 4824 2401
Rps29 5538 3961
Rps3 -3360 -6572
Rps3a1 -4715 -7198
Rps4x -4467 -7052
Rps5 2417 -3011
Rps6 -2214 -6731
Rps7 -7427 -8293
Rps8 -2386 -6535
Rps9 -1061 -5313
Rpsa 1252 -4511
Sec11a -3693 -6347
Sec11c -3674 -5158
Sec61a1 8161 7265
Sec61a2 -205 1760
Sec61b -198 -2903
Sec61g -6202 -6700
Spcs1 -5579 -6579
Spcs2 -8004 -8233
Spcs3 -7866 -7690
Srp14 -3346 -6672
Srp19 -5667 -7557
Srp54a -7592 -7830
Srp68 5877 6003
Srp72 -4723 -2693
Srp9 -4214 -6016
Srpr 3252 2686
Srprb 4577 130
Ssr1 -7954 -7118
Ssr2 2083 -2416
Ssr3 -7794 -7264
Ssr4 1240 -2666
Tram1 -6916 -3191
Uba52 1246 -3924



CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
metric value
setSize 10
pMANOVA 0.0708
p.adjustMANOVA 0.191
s.dist 0.563
s.LPS -0.383
s.OVA -0.412
p.LPS 0.0358
p.OVA 0.024



Top 20 genes
Gene LPS OVA
Ywhab -7667 -7999
Ywhae -7718 -7899
Ywhaq -7030 -8249
Ywhaz -7538 -6157
Chek2 -4878 -5888
Ywhah -2653 -6924
Chek1 -2085 -3036

Click HERE to show all gene set members

All member genes
LPS OVA
Chek1 -2085 -3036
Chek2 -4878 -5888
Sfn 5929 6684
Wee1 -1036 943
Ywhab -7667 -7999
Ywhae -7718 -7899
Ywhag 4921 4875
Ywhah -2653 -6924
Ywhaq -7030 -8249
Ywhaz -7538 -6157



NRAGE SIGNALS DEATH THROUGH JNK
NRAGE SIGNALS DEATH THROUGH JNK
metric value
setSize 55
pMANOVA 1.44e-07
p.adjustMANOVA 2.51e-06
s.dist 0.559
s.LPS 0.348
s.OVA 0.437
p.LPS 7.99e-06
p.OVA 2.02e-08



Top 20 genes
Gene LPS OVA
Arhgef10 8007 8238
Arhgef5 8081 8095
Arhgef4 8318 7841
Plekhg5 8198 7942
Plekhg2 7998 8129
Arhgef18 7827 7801
Vav2 7281 8345
Arhgef17 7807 7678
Mcf2l 7260 8175
Obscn 6932 8367
Arhgef2 7507 7655
Arhgef1 7313 7634
Arhgef7 7231 7685
Prex1 7908 6916
Arhgef11 7314 7429
Abr 6960 7405
Arhgef40 7435 6886
Fgd1 7756 6522
Arhgef10l 7916 6372
Kalrn 6514 7738

Click HERE to show all gene set members

All member genes
LPS OVA
Aatf 813 990
Abr 6960 7405
Akap13 5817 7842
Arhgef1 7313 7634
Arhgef10 8007 8238
Arhgef10l 7916 6372
Arhgef11 7314 7429
Arhgef12 2143 6209
Arhgef15 3332 -3860
Arhgef16 3072 2400
Arhgef17 7807 7678
Arhgef18 7827 7801
Arhgef19 7209 6681
Arhgef2 7507 7655
Arhgef26 443 1954
Arhgef3 -2852 1620
Arhgef33 4097 5552
Arhgef37 374 4165
Arhgef4 8318 7841
Arhgef40 7435 6886
Arhgef5 8081 8095
Arhgef6 3315 6047
Arhgef7 7231 7685
Arhgef9 -3515 442
Bad 6726 -373
Bcl2l11 -589 -1031
Fgd1 7756 6522
Fgd2 4918 5413
Fgd3 5705 1878
Fgd4 -6725 -316
Gna13 -1922 938
Itsn1 4988 6276
Kalrn 6514 7738
Maged1 3565 2752
Mapk8 -7573 -5666
Mcf2 -6007 -6539
Mcf2l 7260 8175
Net1 -3808 120
Ngef 1287 -1222
Ngf 4685 1638
Ngfr -1274 -5308
Obscn 6932 8367
Plekhg2 7998 8129
Plekhg5 8198 7942
Prex1 7908 6916
Rac1 -4941 -5758
Rasgrf2 4352 7216
Sos1 -5268 -258
Sos2 -5539 -1950
Tiam1 2548 5182
Tiam2 -857 3368
Trio 5359 7479
Vav1 1899 1135
Vav2 7281 8345
Vav3 -3585 -1058



RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
metric value
setSize 94
pMANOVA 4.95e-33
p.adjustMANOVA 8.28e-31
s.dist 0.556
s.LPS -0.151
s.OVA -0.535
p.LPS 0.0115
p.OVA 2.87e-19



Top 20 genes
Gene LPS OVA
Rps18 -8130 -8305
Eif2s2 -7829 -8273
Eif2s1 -7855 -8029
Rps7 -7427 -8293
Rpl22l1 -7572 -8091
Cebpg -7908 -7733
Rpl35a -7117 -8275
Rpl30 -6708 -8242
Rpl5 -6829 -7990
Rps2 -6489 -7719
Eif2s3x -7526 -6601
Impact -7873 -6224
Atf2 -7752 -5392
Rpl3 -5307 -7374
Rpl27a -4838 -7757
Rps3a1 -4715 -7198
Rpl15 -4649 -7096
Rpl29 -4311 -7541
Rpl24 -4860 -6684
Rps4x -4467 -7052

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -4906 -6304
Atf2 -7752 -5392
Atf3 1030 -1046
Atf4 4881 -347
Cebpb 7947 6786
Cebpg -7908 -7733
Ddit3 7053 204
Eif2ak4 5312 8231
Eif2s1 -7855 -8029
Eif2s2 -7829 -8273
Eif2s3x -7526 -6601
Fau 2623 -3236
Gcn1 8529 8421
Impact -7873 -6224
Rpl10 2426 507
Rpl10a 991 -4760
Rpl11 -2506 -6268
Rpl12 3958 942
Rpl13 3378 -1929
Rpl13a -2548 -6500
Rpl14 -3852 -6216
Rpl15 -4649 -7096
Rpl17 -3129 -6498
Rpl18 2997 -2908
Rpl18a 305 -5495
Rpl19 1011 -3677
Rpl21 1147 -4968
Rpl22 -4098 -6121
Rpl22l1 -7572 -8091
Rpl23 -2535 -5397
Rpl23a -430 -5509
Rpl24 -4860 -6684
Rpl26 -4006 -7479
Rpl27 -286 -4951
Rpl27a -4838 -7757
Rpl28 1738 -3913
Rpl29 -4311 -7541
Rpl3 -5307 -7374
Rpl30 -6708 -8242
Rpl31 108 -5142
Rpl32 552 -3621
Rpl34 2273 -2980
Rpl35 1205 -1839
Rpl35a -7117 -8275
Rpl36 4588 -161
Rpl36a -3374 -7575
Rpl36al 1237 -4876
Rpl37 3846 143
Rpl37a 2792 -3065
Rpl38 4256 1285
Rpl39 520 -2708
Rpl4 -3203 -6176
Rpl5 -6829 -7990
Rpl6 -4397 -6938
Rpl7 -3882 -6566
Rpl7a 1582 -4324
Rpl8 2867 -2597
Rpl9 -3189 -6717
Rplp0 -2962 -8016
Rplp1 2429 -2664
Rplp2 3911 -423
Rps10 1539 -4276
Rps11 539 -4479
Rps12 3922 -1797
Rps13 -3079 -6003
Rps14 -1149 -6094
Rps15 2982 -2178
Rps15a -263 -3338
Rps16 -1650 -5139
Rps17 356 -3811
Rps18 -8130 -8305
Rps19 -305 -4696
Rps2 -6489 -7719
Rps20 789 -5037
Rps21 1676 -1411
Rps23 -2520 -6494
Rps24 -4143 -7542
Rps25 -1837 -5672
Rps26 726 -3828
Rps27 257 -3604
Rps27a -4152 -6449
Rps27l -3638 -5928
Rps28 4824 2401
Rps29 5538 3961
Rps3 -3360 -6572
Rps3a1 -4715 -7198
Rps4x -4467 -7052
Rps5 2417 -3011
Rps6 -2214 -6731
Rps7 -7427 -8293
Rps8 -2386 -6535
Rps9 -1061 -5313
Rpsa 1252 -4511
Uba52 1246 -3924



SYNAPTIC ADHESION LIKE MOLECULES
SYNAPTIC ADHESION LIKE MOLECULES
metric value
setSize 21
pMANOVA 0.0038
p.adjustMANOVA 0.0199
s.dist 0.554
s.LPS 0.362
s.OVA 0.419
p.LPS 0.00405
p.OVA 0.000881



Top 20 genes
Gene LPS OVA
Ptprs 8485 8457
Grin2c 8520 8172
Grin1 8383 8072
Grin2d 8017 7111
Ptprf 7536 7558
Lrfn2 7224 7367
Lrfn1 8143 5662
Lrfn4 8243 5518
Flot2 7154 4806
Lrfn3 7443 4321
Dlg4 6438 4822
Gria1 3657 5561
Flot1 4877 2101
Dlg3 2870 2708
Grin2a 982 7074
Grin2b 1076 5957

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All member genes
LPS OVA
Dlg1 -7126 -5971
Dlg3 2870 2708
Dlg4 6438 4822
Flot1 4877 2101
Flot2 7154 4806
Gria1 3657 5561
Gria3 -6643 -1071
Gria4 -6452 -6170
Grin1 8383 8072
Grin2a 982 7074
Grin2b 1076 5957
Grin2c 8520 8172
Grin2d 8017 7111
Lrfn1 8143 5662
Lrfn2 7224 7367
Lrfn3 7443 4321
Lrfn4 8243 5518
Ptprd -3397 788
Ptprf 7536 7558
Ptprs 8485 8457
Rtn3 -6458 -6902



COHESIN LOADING ONTO CHROMATIN
COHESIN LOADING ONTO CHROMATIN
metric value
setSize 10
pMANOVA 0.000492
p.adjustMANOVA 0.00353
s.dist 0.554
s.LPS -0.531
s.OVA -0.157
p.LPS 0.00362
p.OVA 0.389



Top 20 genes
Gene LPS OVA
Smc3 -7944 -7954
Rad21 -7701 -7073
Stag2 -7547 -4626
Smc1a -3181 -3970
Wapl -5843 -1401
Stag1 -4159 -1106
Pds5b -6319 -701

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All member genes
LPS OVA
Mau2 8610 8498
Nipbl -4829 1847
Pds5a -3267 4254
Pds5b -6319 -701
Rad21 -7701 -7073
Smc1a -3181 -3970
Smc3 -7944 -7954
Stag1 -4159 -1106
Stag2 -7547 -4626
Wapl -5843 -1401



ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
metric value
setSize 19
pMANOVA 0.00221
p.adjustMANOVA 0.0129
s.dist 0.552
s.LPS -0.314
s.OVA -0.454
p.LPS 0.0177
p.OVA 0.00062



Top 20 genes
Gene LPS OVA
P2ry12 -7206 -7402
Gnai3 -6911 -7170
Gng12 -6646 -7144
Gng11 -5718 -8201
Gnai1 -6635 -6258
Gng10 -5616 -7171
Gnb4 -5893 -5363
Gng2 -7335 -4081
Gnb1 -5183 -5070
Gng5 -4102 -4345
Gng4 -2567 -2443
Gng3 -1008 -3996

Click HERE to show all gene set members

All member genes
LPS OVA
Gnai1 -6635 -6258
Gnai2 4743 471
Gnai3 -6911 -7170
Gnb1 -5183 -5070
Gnb2 6737 2149
Gnb4 -5893 -5363
Gnb5 1596 -446
Gng10 -5616 -7171
Gng11 -5718 -8201
Gng12 -6646 -7144
Gng13 874 -2150
Gng2 -7335 -4081
Gng3 -1008 -3996
Gng4 -2567 -2443
Gng5 -4102 -4345
Gng7 4483 2544
Gng8 846 909
Gngt2 30 -5317
P2ry12 -7206 -7402



PROTEIN METHYLATION
PROTEIN METHYLATION
metric value
setSize 17
pMANOVA 0.00136
p.adjustMANOVA 0.00868
s.dist 0.541
s.LPS -0.268
s.OVA -0.469
p.LPS 0.0557
p.OVA 0.000807



Top 20 genes
Gene LPS OVA
Calm1 -7790 -8217
Rps2 -6489 -7719
Eef1akmt2 -6809 -7226
Kin -4855 -7179
Vcpkmt -3986 -7176
Etfbkmt -5147 -5215
Vcp -2648 -6324
Etfb -2466 -5343
Camkmt -3871 -2748
Hspa8 -1271 -7870
Mettl21a -4418 -1882
Eef1a1 -437 -5727

Click HERE to show all gene set members

All member genes
LPS OVA
Calm1 -7790 -8217
Camkmt -3871 -2748
Eef1a1 -437 -5727
Eef1akmt1 1257 -4702
Eef1akmt2 -6809 -7226
Eef2 5949 -743
Eef2kmt 2912 2315
Etfb -2466 -5343
Etfbkmt -5147 -5215
Hspa8 -1271 -7870
Kin -4855 -7179
Mettl21a -4418 -1882
Mettl22 6249 5335
Prmt3 -298 5102
Rps2 -6489 -7719
Vcp -2648 -6324
Vcpkmt -3986 -7176



REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
metric value
setSize 10
pMANOVA 0.0379
p.adjustMANOVA 0.124
s.dist 0.538
s.LPS 0.294
s.OVA 0.45
p.LPS 0.107
p.OVA 0.0137



Top 20 genes
Gene LPS OVA
Slit1 8332 8343
Src 8215 7958
Slit3 5956 6992
Nell2 6159 5274
Robo3 4450 3233
Ntn1 4247 3083
Robo1 1075 4276

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All member genes
LPS OVA
Dcc -2819 2108
Nell2 6159 5274
Ntn1 4247 3083
Robo1 1075 4276
Robo2 -2642 1877
Robo3 4450 3233
Slit1 8332 8343
Slit2 -5837 -4364
Slit3 5956 6992
Src 8215 7958



REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
metric value
setSize 17
pMANOVA 0.00361
p.adjustMANOVA 0.0192
s.dist 0.528
s.LPS 0.28
s.OVA 0.447
p.LPS 0.0454
p.OVA 0.00142



Top 20 genes
Gene LPS OVA
Src 8215 7958
Mov10 7346 8225
Pml 6839 7067
Ptpn11 6126 6039
Ago1 4775 7005
Ago2 4452 7398
Ccnd3 7750 3449
Tnrc6c 2921 7477
Cdk6 2167 5996
Ago3 1717 7046
Ccnd2 3995 2958
Tnrc6a 113 5665

Click HERE to show all gene set members

All member genes
LPS OVA
Ago1 4775 7005
Ago2 4452 7398
Ago3 1717 7046
Ago4 -2338 -3781
Cbfb -7188 -4492
Ccnd1 -1472 -5087
Ccnd2 3995 2958
Ccnd3 7750 3449
Cdk6 2167 5996
Mov10 7346 8225
Pml 6839 7067
Ptpn11 6126 6039
Runx1 -1057 -2880
Src 8215 7958
Tnrc6a 113 5665
Tnrc6b -222 5402
Tnrc6c 2921 7477



COMPLEX I BIOGENESIS
COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 1.46e-16
p.adjustMANOVA 8.16e-15
s.dist 0.515
s.LPS -0.149
s.OVA -0.493
p.LPS 0.0546
p.OVA 1.67e-10



Top 20 genes
Gene LPS OVA
mt-Nd3 -7874 -8167
Ndufv2 -7328 -8174
Ndufc2 -6812 -8134
Ndufaf2 -6867 -7986
Ndufaf4 -6920 -7762
Ndufaf1 -7035 -7466
Ndufs4 -6421 -7732
mt-Nd2 -6415 -7642
mt-Nd1 -6076 -7726
Ndufb4 -5841 -7567
mt-Nd6 -6018 -6997
mt-Nd4 -5658 -7299
mt-Nd5 -5993 -6665
Ndufb5 -5145 -7000
Nubpl -5269 -6354
Ndufaf5 -4414 -7122
Ndufc1 -4785 -6443
Ndufb6 -3959 -6726
Ndufs1 -5457 -4815
Ndufa9 -4216 -6212

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All member genes
LPS OVA
Acad9 1998 1413
Ecsit 7345 5392
mt-Nd1 -6076 -7726
mt-Nd2 -6415 -7642
mt-Nd3 -7874 -8167
mt-Nd4 -5658 -7299
mt-Nd5 -5993 -6665
mt-Nd6 -6018 -6997
Ndufa1 965 -2318
Ndufa10 -2858 -7641
Ndufa11 6111 754
Ndufa12 -1351 -5832
Ndufa13 5332 -109
Ndufa2 3800 114
Ndufa3 6147 3397
Ndufa5 -2849 -5701
Ndufa6 1534 -3933
Ndufa7 3625 -913
Ndufa8 -2092 -6242
Ndufa9 -4216 -6212
Ndufab1 2829 -1605
Ndufaf1 -7035 -7466
Ndufaf2 -6867 -7986
Ndufaf3 3749 -996
Ndufaf4 -6920 -7762
Ndufaf5 -4414 -7122
Ndufaf6 26 -4371
Ndufaf7 -5795 -2627
Ndufb1 458 -1830
Ndufb10 4608 92
Ndufb11 1375 -4662
Ndufb2 734 -5009
Ndufb3 -1525 -6000
Ndufb4 -5841 -7567
Ndufb5 -5145 -7000
Ndufb6 -3959 -6726
Ndufb7 4621 -669
Ndufb8 3273 -4534
Ndufb9 -1642 -5836
Ndufc1 -4785 -6443
Ndufc2 -6812 -8134
Ndufs1 -5457 -4815
Ndufs2 220 -6046
Ndufs3 -421 -3523
Ndufs4 -6421 -7732
Ndufs5 -164 -5226
Ndufs6 -958 -4960
Ndufs7 6912 2929
Ndufs8 5991 -3676
Ndufv1 3482 -2422
Ndufv2 -7328 -8174
Ndufv3 5346 1299
Nubpl -5269 -6354
Timmdc1 -82 -1635
Tmem126b -2542 -4509
Tmem186 4285 5443



EARLY PHASE OF HIV LIFE CYCLE
EARLY PHASE OF HIV LIFE CYCLE
metric value
setSize 13
pMANOVA 0.0521
p.adjustMANOVA 0.154
s.dist 0.515
s.LPS -0.339
s.OVA -0.387
p.LPS 0.0343
p.OVA 0.0156



Top 20 genes
Gene LPS OVA
Psip1 -7853 -8154
Xrcc5 -7452 -7501
Xrcc4 -6694 -7587
Ccr5 -5666 -7554
Kpna1 -7596 -5403
Ppia -4874 -7796
Lig4 -5816 -4771
Xrcc6 -2283 -35

Click HERE to show all gene set members

All member genes
LPS OVA
Banf1 1758 -2543
Ccr5 -5666 -7554
Cxcr4 2212 -1631
Fen1 -375 1429
Hmga1 6778 6861
Kpna1 -7596 -5403
Lig1 4023 3676
Lig4 -5816 -4771
Ppia -4874 -7796
Psip1 -7853 -8154
Xrcc4 -6694 -7587
Xrcc5 -7452 -7501
Xrcc6 -2283 -35



POST CHAPERONIN TUBULIN FOLDING PATHWAY
POST CHAPERONIN TUBULIN FOLDING PATHWAY
metric value
setSize 17
pMANOVA 2.78e-10
p.adjustMANOVA 9.04e-09
s.dist 0.512
s.LPS 0.511
s.OVA -0.0334
p.LPS 0.000264
p.OVA 0.811



Top 20 genes
Gene LPS OVA
Tuba1b 6005 -3367
Tuba4a 4458 -3396
Tuba1a 4328 -3116
Tbcb 3300 -3948
Tubb6 6727 -1503
Tubb4b 7728 -813
Tbcc 1406 -2663
Tuba8 1016 -1883

Click HERE to show all gene set members

All member genes
LPS OVA
Arl2 6753 42
Tbca -6607 -7084
Tbcb 3300 -3948
Tbcc 1406 -2663
Tbcd 8113 7666
Tbce -2704 -2820
Tuba1a 4328 -3116
Tuba1b 6005 -3367
Tuba1c 7234 8326
Tuba4a 4458 -3396
Tuba8 1016 -1883
Tubb2a 7758 4666
Tubb2b 5464 1610
Tubb3 7739 435
Tubb4a 8354 4734
Tubb4b 7728 -813
Tubb6 6727 -1503



TRIGLYCERIDE CATABOLISM
TRIGLYCERIDE CATABOLISM
metric value
setSize 14
pMANOVA 0.00918
p.adjustMANOVA 0.0399
s.dist 0.51
s.LPS -0.258
s.OVA -0.44
p.LPS 0.0946
p.OVA 0.00437



Top 20 genes
Gene LPS OVA
Fabp7 -7384 -8241
Prkacb -7700 -7591
Ppp1cb -8086 -7049
Abhd5 -5683 -6278
Gpd2 -6605 -5398
Fabp5 -4420 -7172
Ppp1cc -2453 -3581
Cav1 -2381 -3314
Plin3 -385 -3275

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All member genes
LPS OVA
Abhd5 -5683 -6278
Cav1 -2381 -3314
Fabp3 2208 -3519
Fabp5 -4420 -7172
Fabp7 -7384 -8241
Gpd2 -6605 -5398
Lipe 6937 2664
Mgll 4082 744
Plin3 -385 -3275
Ppp1ca 537 -3984
Ppp1cb -8086 -7049
Ppp1cc -2453 -3581
Prkaca 4408 5644
Prkacb -7700 -7591



G BETA GAMMA SIGNALLING THROUGH CDC42
G BETA GAMMA SIGNALLING THROUGH CDC42
metric value
setSize 18
pMANOVA 0.00961
p.adjustMANOVA 0.0415
s.dist 0.509
s.LPS -0.301
s.OVA -0.411
p.LPS 0.027
p.OVA 0.00254



Top 20 genes
Gene LPS OVA
Cdc42 -8072 -8187
Pak1 -6863 -8066
Gng12 -6646 -7144
Gng11 -5718 -8201
Gng10 -5616 -7171
Gnb4 -5893 -5363
Gng2 -7335 -4081
Gnb1 -5183 -5070
Gng5 -4102 -4345
Gng4 -2567 -2443
Gng3 -1008 -3996

Click HERE to show all gene set members

All member genes
LPS OVA
Arhgef6 3315 6047
Cdc42 -8072 -8187
Gnb1 -5183 -5070
Gnb2 6737 2149
Gnb4 -5893 -5363
Gnb5 1596 -446
Gng10 -5616 -7171
Gng11 -5718 -8201
Gng12 -6646 -7144
Gng13 874 -2150
Gng2 -7335 -4081
Gng3 -1008 -3996
Gng4 -2567 -2443
Gng5 -4102 -4345
Gng7 4483 2544
Gng8 846 909
Gngt2 30 -5317
Pak1 -6863 -8066



SELENOAMINO ACID METABOLISM
SELENOAMINO ACID METABOLISM
metric value
setSize 109
pMANOVA 3.53e-31
p.adjustMANOVA 4.13e-29
s.dist 0.5
s.LPS -0.135
s.OVA -0.482
p.LPS 0.0153
p.OVA 3.55e-18



Top 20 genes
Gene LPS OVA
Rps18 -8130 -8305
Hnmt -8095 -8040
Rps7 -7427 -8293
Rpl22l1 -7572 -8091
Eef1e1 -7296 -8294
Dars -8019 -7415
Rpl35a -7117 -8275
Rpl30 -6708 -8242
Rpl5 -6829 -7990
Rars -6884 -7618
Rps2 -6489 -7719
Aimp1 -5657 -7520
Rpl3 -5307 -7374
Rpl27a -4838 -7757
Rps3a1 -4715 -7198
Rpl15 -4649 -7096
Rpl29 -4311 -7541
Rpl24 -4860 -6684
Rps4x -4467 -7052
Rps24 -4143 -7542

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All member genes
LPS OVA
Ahcy -4028 -7538
Aimp1 -5657 -7520
Aimp2 3817 -454
Cbs 1898 -2586
Cth -3047 2432
Dars -8019 -7415
Eef1e1 -7296 -8294
Eefsec 5344 1255
Eprs -4407 -5002
Fau 2623 -3236
Gnmt 3599 5990
Gsr -3582 -2658
Hnmt -8095 -8040
Iars 4557 5482
Inmt 1351 -449
Kars 1436 -3365
Lars -3743 -1207
Mars1 7943 6650
Papss1 144 -2774
Papss2 -3570 -4736
Pstk -1356 -5568
Qars 5736 6256
Rars -6884 -7618
Rpl10 2426 507
Rpl10a 991 -4760
Rpl11 -2506 -6268
Rpl12 3958 942
Rpl13 3378 -1929
Rpl13a -2548 -6500
Rpl14 -3852 -6216
Rpl15 -4649 -7096
Rpl17 -3129 -6498
Rpl18 2997 -2908
Rpl18a 305 -5495
Rpl19 1011 -3677
Rpl21 1147 -4968
Rpl22 -4098 -6121
Rpl22l1 -7572 -8091
Rpl23 -2535 -5397
Rpl23a -430 -5509
Rpl24 -4860 -6684
Rpl26 -4006 -7479
Rpl27 -286 -4951
Rpl27a -4838 -7757
Rpl28 1738 -3913
Rpl29 -4311 -7541
Rpl3 -5307 -7374
Rpl30 -6708 -8242
Rpl31 108 -5142
Rpl32 552 -3621
Rpl34 2273 -2980
Rpl35 1205 -1839
Rpl35a -7117 -8275
Rpl36 4588 -161
Rpl36a -3374 -7575
Rpl36al 1237 -4876
Rpl37 3846 143
Rpl37a 2792 -3065
Rpl38 4256 1285
Rpl39 520 -2708
Rpl4 -3203 -6176
Rpl5 -6829 -7990
Rpl6 -4397 -6938
Rpl7 -3882 -6566
Rpl7a 1582 -4324
Rpl8 2867 -2597
Rpl9 -3189 -6717
Rplp0 -2962 -8016
Rplp1 2429 -2664
Rplp2 3911 -423
Rps10 1539 -4276
Rps11 539 -4479
Rps12 3922 -1797
Rps13 -3079 -6003
Rps14 -1149 -6094
Rps15 2982 -2178
Rps15a -263 -3338
Rps16 -1650 -5139
Rps17 356 -3811
Rps18 -8130 -8305
Rps19 -305 -4696
Rps2 -6489 -7719
Rps20 789 -5037
Rps21 1676 -1411
Rps23 -2520 -6494
Rps24 -4143 -7542
Rps25 -1837 -5672
Rps26 726 -3828
Rps27 257 -3604
Rps27a -4152 -6449
Rps27l -3638 -5928
Rps28 4824 2401
Rps29 5538 3961
Rps3 -3360 -6572
Rps3a1 -4715 -7198
Rps4x -4467 -7052
Rps5 2417 -3011
Rps6 -2214 -6731
Rps7 -7427 -8293
Rps8 -2386 -6535
Rps9 -1061 -5313
Rpsa 1252 -4511
Sars -1745 -7140
Scly 5493 1967
Secisbp2 7289 8247
Sephs2 -219 -4633
Sepsecs -4026 2299
Txnrd1 -41 3621
Uba52 1246 -3924



SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
metric value
setSize 20
pMANOVA 0.0158
p.adjustMANOVA 0.0615
s.dist 0.5
s.LPS -0.345
s.OVA -0.362
p.LPS 0.0075
p.OVA 0.00512



Top 20 genes
Gene LPS OVA
Hsd17b12 -7218 -8232
Acsl3 -8046 -6962
Hacd3 -7139 -7807
Acsl4 -8070 -6629
Elovl7 -7006 -7628
Elovl4 -7423 -6671
Elovl5 -6075 -7532
Acsl5 -5501 -7663
Elovl2 -5378 -6267
Hacd1 -5121 -5803
Hacd2 -3820 -1709
Acsl6 -2678 -2174
Hacd4 -3326 -437

Click HERE to show all gene set members

All member genes
LPS OVA
Acsbg1 7065 -21
Acsf3 484 -419
Acsl1 -2928 1742
Acsl3 -8046 -6962
Acsl4 -8070 -6629
Acsl5 -5501 -7663
Acsl6 -2678 -2174
Elovl1 7397 4424
Elovl2 -5378 -6267
Elovl4 -7423 -6671
Elovl5 -6075 -7532
Elovl6 -939 3033
Elovl7 -7006 -7628
Hacd1 -5121 -5803
Hacd2 -3820 -1709
Hacd3 -7139 -7807
Hacd4 -3326 -437
Hsd17b12 -7218 -8232
Slc27a3 8426 7904
Tecr 4190 101



SIGNALING BY LEPTIN
SIGNALING BY LEPTIN
metric value
setSize 10
pMANOVA 0.0365
p.adjustMANOVA 0.12
s.dist 0.498
s.LPS 0.247
s.OVA 0.433
p.LPS 0.176
p.OVA 0.0178



Top 20 genes
Gene LPS OVA
Sh2b1 8630 8133
Ptpn11 6126 6039
Stat3 5607 6416
Stat5a 3247 2939
Irs1 2145 4446
Irs2 2425 3367
Stat5b 1313 4816

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All member genes
LPS OVA
Irs1 2145 4446
Irs2 2425 3367
Jak2 -3208 4312
Lepr -6180 -2457
Ptpn11 6126 6039
Sh2b1 8630 8133
Socs3 3065 -677
Stat3 5607 6416
Stat5a 3247 2939
Stat5b 1313 4816



TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
metric value
setSize 11
pMANOVA 0.00677
p.adjustMANOVA 0.0317
s.dist 0.498
s.LPS -0.196
s.OVA -0.458
p.LPS 0.26
p.OVA 0.00853



Top 20 genes
Gene LPS OVA
Hsp90b1 -8033 -8274
Tlr3 -7846 -8182
Ctsl -6095 -7915
Ctss -5276 -7894
Ctsb -2010 -6490
Lgmn -1646 -5753
Tlr7 -1298 -1917

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All member genes
LPS OVA
Cnpy3 6275 1831
Ctsb -2010 -6490
Ctsk 736 -1448
Ctsl -6095 -7915
Ctss -5276 -7894
Hsp90b1 -8033 -8274
Lgmn -1646 -5753
Tlr3 -7846 -8182
Tlr7 -1298 -1917
Tlr9 6140 2335
Unc93b1 3605 2469



NCAM1 INTERACTIONS
NCAM1 INTERACTIONS
metric value
setSize 40
pMANOVA 0.000122
p.adjustMANOVA 0.00105
s.dist 0.498
s.LPS 0.313
s.OVA 0.388
p.LPS 0.000625
p.OVA 2.19e-05



Top 20 genes
Gene LPS OVA
Cacna1h 8563 8468
Agrn 7354 7836
Cacna1d 6144 8257
Col9a3 6337 7597
Cacna1i 6628 7190
Cacnb1 6557 6670
Cacna1c 5585 7194
Ncan 5756 6787
Col4a2 6179 6210
Cacnb3 7270 5276
Cacna1g 5764 5816
Col4a1 5567 5828
Cntn2 5752 5519
Col4a3 3773 7474
Col2a1 4615 5094
Col4a5 4193 5169
Gfra4 5404 3979
Col6a3 3132 5435
Gfra1 3203 4830
Gfra2 2109 5587

Click HERE to show all gene set members

All member genes
LPS OVA
Agrn 7354 7836
Artn 2805 -530
Cacna1c 5585 7194
Cacna1d 6144 8257
Cacna1g 5764 5816
Cacna1h 8563 8468
Cacna1i 6628 7190
Cacna1s 1889 2968
Cacnb1 6557 6670
Cacnb2 64 4068
Cacnb3 7270 5276
Cacnb4 -7847 -6580
Cntn2 5752 5519
Col2a1 4615 5094
Col3a1 -3804 -6706
Col4a1 5567 5828
Col4a2 6179 6210
Col4a3 3773 7474
Col4a4 2343 4535
Col4a5 4193 5169
Col5a1 425 3732
Col5a2 1371 2653
Col5a3 1099 2893
Col6a1 1086 3263
Col6a2 -508 2528
Col6a3 3132 5435
Col6a5 1486 1980
Col6a6 -568 4358
Col9a1 -1526 -1142
Col9a2 2079 -1024
Col9a3 6337 7597
Gfra1 3203 4830
Gfra2 2109 5587
Gfra4 5404 3979
Ncam1 3047 3572
Ncan 5756 6787
Nrtn 7215 -2203
Prnp -3185 -6391
St8sia2 4365 1347
St8sia4 -7162 -5587



REPRESSION OF WNT TARGET GENES
REPRESSION OF WNT TARGET GENES
metric value
setSize 14
pMANOVA 0.0408
p.adjustMANOVA 0.131
s.dist 0.495
s.LPS 0.39
s.OVA 0.305
p.LPS 0.0116
p.OVA 0.0478



Top 20 genes
Gene LPS OVA
Axin2 7323 7121
Tle1 7201 7084
Myc 5725 7518
Ctbp2 6784 6221
Tle2 6418 5750
Tle3 4785 7095
Tcf7l1 5058 1305
Ctbp1 6292 877
Hdac1 1578 397

Click HERE to show all gene set members

All member genes
LPS OVA
Axin2 7323 7121
Ctbp1 6292 877
Ctbp2 6784 6221
Hdac1 1578 397
Lef1 -1886 -238
Myc 5725 7518
Tcf7 -221 -254
Tcf7l1 5058 1305
Tcf7l2 -2871 -3805
Tle1 7201 7084
Tle2 6418 5750
Tle3 4785 7095
Tle4 -2469 -1216
Tle5 5518 -582



INTERLEUKIN 12 SIGNALING
INTERLEUKIN 12 SIGNALING
metric value
setSize 37
pMANOVA 4.61e-06
p.adjustMANOVA 6.2e-05
s.dist 0.494
s.LPS -0.241
s.OVA -0.431
p.LPS 0.0111
p.OVA 5.68e-06



Top 20 genes
Gene LPS OVA
Cdc42 -8072 -8187
Tcp1 -7625 -8207
Rap1b -7860 -7822
Hnrnpdl -6740 -7875
Pdcd4 -7511 -6939
Hnrnpa2b1 -7016 -7329
Rala -6904 -7386
Hspa9 -6632 -7413
Ppia -4874 -7796
Capza1 -6508 -5750
Pak2 -6919 -4956
Mtap -3885 -6771
Rplp0 -2962 -8016
Sod2 -6105 -3719
Psme2 -3440 -6537
Hnrnpf -4213 -4631
Snrpa1 -3604 -5179
Lcp1 -2725 -5801
Jak1 -3165 -2000
Pitpna -2645 -1681

Click HERE to show all gene set members

All member genes
LPS OVA
Aip 4002 -2593
Anxa2 5322 502
Arf1 2086 -557
Bola2 4081 -8
Capza1 -6508 -5750
Cdc42 -8072 -8187
Cfl1 4853 -2988
Cnn2 51 -4978
Gsto1 -780 -5500
Hnrnpa2b1 -7016 -7329
Hnrnpdl -6740 -7875
Hnrnpf -4213 -4631
Hspa9 -6632 -7413
Il12a -1772 -353
Il12rb1 4186 5159
Jak1 -3165 -2000
Jak2 -3208 4312
Lcp1 -2725 -5801
Lmnb1 2926 1453
Mif 7927 3962
Msn -493 -1247
Mtap -3885 -6771
P4hb -599 -4337
Pak2 -6919 -4956
Pdcd4 -7511 -6939
Pitpna -2645 -1681
Ppia -4874 -7796
Psme2 -3440 -6537
Rala -6904 -7386
Rap1b -7860 -7822
Rplp0 -2962 -8016
Snrpa1 -3604 -5179
Sod1 3521 -3185
Sod2 -6105 -3719
Taldo1 3563 -3777
Tcp1 -7625 -8207
Tyk2 7877 7996



CELLULAR HEXOSE TRANSPORT
CELLULAR HEXOSE TRANSPORT
metric value
setSize 11
pMANOVA 0.0917
p.adjustMANOVA 0.23
s.dist 0.493
s.LPS 0.381
s.OVA 0.313
p.LPS 0.0288
p.OVA 0.072



Top 20 genes
Gene LPS OVA
Slc2a6 8637 7975
Slc2a8 8399 8056
Slc2a1 6642 5088
Slc50a1 5952 4699
Slc2a10 3464 1060
Slc2a4 1953 707
Slc2a9 176 3853

Click HERE to show all gene set members

All member genes
LPS OVA
Mfsd4b1 2646 -2956
Slc2a1 6642 5088
Slc2a10 3464 1060
Slc2a12 -2000 170
Slc2a3 -961 2434
Slc2a4 1953 707
Slc2a6 8637 7975
Slc2a8 8399 8056
Slc2a9 176 3853
Slc45a3 2931 -1070
Slc50a1 5952 4699



NOTCH HLH TRANSCRIPTION PATHWAY
NOTCH HLH TRANSCRIPTION PATHWAY
metric value
setSize 28
pMANOVA 0.00101
p.adjustMANOVA 0.00682
s.dist 0.489
s.LPS 0.283
s.OVA 0.399
p.LPS 0.00959
p.OVA 0.000259



Top 20 genes
Gene LPS OVA
Ncor2 8539 8431
Crebbp 7829 8436
Notch1 8135 8109
Notch3 8254 7808
Hdac6 8154 7365
Notch4 7743 7743
Hdac7 7585 7716
Notch2 6892 8156
Hdac5 7996 6652
Hdac4 4563 7045
Kat2a 6237 4508
Hdac11 5665 4418
Hdac10 4839 4747
Maml3 5015 4296
Maml1 4890 3648
Mamld1 2229 7790
Hdac3 3533 1875
Maml2 1073 3312
Hdac8 3201 897
Hdac1 1578 397

Click HERE to show all gene set members

All member genes
LPS OVA
Crebbp 7829 8436
Hdac1 1578 397
Hdac10 4839 4747
Hdac11 5665 4418
Hdac2 -7494 -7513
Hdac3 3533 1875
Hdac4 4563 7045
Hdac5 7996 6652
Hdac6 8154 7365
Hdac7 7585 7716
Hdac8 3201 897
Hdac9 -6278 -3778
Kat2a 6237 4508
Kat2b -5130 -319
Maml1 4890 3648
Maml2 1073 3312
Maml3 5015 4296
Mamld1 2229 7790
Ncor1 -57 2992
Ncor2 8539 8431
Notch1 8135 8109
Notch2 6892 8156
Notch3 8254 7808
Notch4 7743 7743
Rbpj -1273 2626
Snw1 -7196 -7751
Tbl1x -6209 -2518
Tbl1xr1 -7054 -666



NEGATIVE REGULATION OF NOTCH4 SIGNALING
NEGATIVE REGULATION OF NOTCH4 SIGNALING
metric value
setSize 54
pMANOVA 2.27e-10
p.adjustMANOVA 8.03e-09
s.dist 0.488
s.LPS -0.201
s.OVA -0.445
p.LPS 0.0106
p.OVA 1.59e-08



Top 20 genes
Gene LPS OVA
Skp1 -8036 -8257
Fbxw7 -7813 -8169
Psmc6 -7882 -7903
Psmd12 -7586 -8164
Psmc1 -7200 -8230
Psma3 -7262 -7959
Psma6 -6856 -8033
Psmd14 -7260 -7506
Psmd10 -6565 -7185
Ywhaz -7538 -6157
Psmd1 -6199 -7001
Psmd6 -5729 -7384
Psmb7 -5546 -7294
Psma5 -5426 -7070
Psma4 -5360 -7108
Psma2 -4919 -7328
Psma1 -5114 -6649
Psmb1 -4486 -7543
Rbx1 -4538 -6745
Psmc2 -4305 -6764

Click HERE to show all gene set members

All member genes
LPS OVA
Akt1 6934 5740
Cul1 -5867 -2757
Fbxw7 -7813 -8169
Notch4 7743 7743
Psma1 -5114 -6649
Psma2 -4919 -7328
Psma3 -7262 -7959
Psma4 -5360 -7108
Psma5 -5426 -7070
Psma6 -6856 -8033
Psma7 480 -5355
Psmb1 -4486 -7543
Psmb10 2001 -2567
Psmb2 2337 1229
Psmb3 5159 -859
Psmb4 1500 -4093
Psmb5 7081 4123
Psmb6 2733 -1694
Psmb7 -5546 -7294
Psmb8 -3414 -6748
Psmb9 -4244 -3009
Psmc1 -7200 -8230
Psmc2 -4305 -6764
Psmc3 4536 -3114
Psmc4 7156 2302
Psmc5 -127 -4588
Psmc6 -7882 -7903
Psmd1 -6199 -7001
Psmd10 -6565 -7185
Psmd11 -2034 654
Psmd12 -7586 -8164
Psmd13 2546 -1418
Psmd14 -7260 -7506
Psmd2 2201 -102
Psmd3 8279 7100
Psmd4 5882 1499
Psmd5 -2930 -3210
Psmd6 -5729 -7384
Psmd7 -3758 -6631
Psmd8 -81 -6375
Psmd9 3732 179
Psme1 -2094 -3119
Psme2 -3440 -6537
Psme3 -2907 -3340
Psmf1 116 388
Rbx1 -4538 -6745
Rps27a -4152 -6449
Sem1 942 -3239
Skp1 -8036 -8257
Tacc3 -337 2307
Uba52 1246 -3924
Ubb 5594 -1688
Ubc 4950 173
Ywhaz -7538 -6157



CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
metric value
setSize 47
pMANOVA 3.12e-09
p.adjustMANOVA 9.36e-08
s.dist 0.487
s.LPS -0.198
s.OVA -0.445
p.LPS 0.0188
p.OVA 1.3e-07



Top 20 genes
Gene LPS OVA
Psmc6 -7882 -7903
Psmd12 -7586 -8164
Psmc1 -7200 -8230
Psma3 -7262 -7959
Psma6 -6856 -8033
Psmd14 -7260 -7506
Psmd10 -6565 -7185
Psmd1 -6199 -7001
Psmd6 -5729 -7384
Psmb7 -5546 -7294
Psma5 -5426 -7070
Psma4 -5360 -7108
Psma2 -4919 -7328
Psma1 -5114 -6649
Psmb1 -4486 -7543
Psmc2 -4305 -6764
Mrc1 -4807 -5869
Psmd7 -3758 -6631
Psmb8 -3414 -6748
Psme2 -3440 -6537

Click HERE to show all gene set members

All member genes
LPS OVA
Fcgr1 -984 -3837
Mrc1 -4807 -5869
Mrc2 5290 446
Psma1 -5114 -6649
Psma2 -4919 -7328
Psma3 -7262 -7959
Psma4 -5360 -7108
Psma5 -5426 -7070
Psma6 -6856 -8033
Psma7 480 -5355
Psmb1 -4486 -7543
Psmb10 2001 -2567
Psmb11 1941 2688
Psmb2 2337 1229
Psmb3 5159 -859
Psmb4 1500 -4093
Psmb5 7081 4123
Psmb6 2733 -1694
Psmb7 -5546 -7294
Psmb8 -3414 -6748
Psmb9 -4244 -3009
Psmc1 -7200 -8230
Psmc2 -4305 -6764
Psmc3 4536 -3114
Psmc4 7156 2302
Psmc5 -127 -4588
Psmc6 -7882 -7903
Psmd1 -6199 -7001
Psmd10 -6565 -7185
Psmd11 -2034 654
Psmd12 -7586 -8164
Psmd13 2546 -1418
Psmd14 -7260 -7506
Psmd2 2201 -102
Psmd3 8279 7100
Psmd4 5882 1499
Psmd5 -2930 -3210
Psmd6 -5729 -7384
Psmd7 -3758 -6631
Psmd8 -81 -6375
Psmd9 3732 179
Psme1 -2094 -3119
Psme2 -3440 -6537
Psme3 -2907 -3340
Psme4 -2016 3543
Psmf1 116 388
Sem1 942 -3239



NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
metric value
setSize 20
pMANOVA 0.0178
p.adjustMANOVA 0.0672
s.dist 0.486
s.LPS 0.321
s.OVA 0.364
p.LPS 0.0129
p.OVA 0.00481



Top 20 genes
Gene LPS OVA
Crebbp 7829 8436
Notch1 8135 8109
Notch4 7743 7743
Notch2 6892 8156
Smad3 5239 6351
Flt4 5279 5707
Kat2a 6237 4508
Ep300 3580 7134
Maml3 5015 4296
Maml1 4890 3648
Mamld1 2229 7790
Hes5 5388 3002
Maml2 1073 3312

Click HERE to show all gene set members

All member genes
LPS OVA
Acta2 914 -2362
Crebbp 7829 8436
Ep300 3580 7134
Flt4 5279 5707
Hes1 4433 -5466
Hes5 5388 3002
Hey1 -424 -1082
Hey2 -2040 -757
Kat2a 6237 4508
Kat2b -5130 -319
Maml1 4890 3648
Maml2 1073 3312
Maml3 5015 4296
Mamld1 2229 7790
Notch1 8135 8109
Notch2 6892 8156
Notch4 7743 7743
Rbpj -1273 2626
Smad3 5239 6351
Snw1 -7196 -7751



DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
metric value
setSize 59
pMANOVA 3.41e-10
p.adjustMANOVA 1.08e-08
s.dist 0.482
s.LPS -0.211
s.OVA -0.433
p.LPS 0.00502
p.OVA 8.83e-09



Top 20 genes
Gene LPS OVA
Erlec1 -8034 -8068
Psmc6 -7882 -7903
Psmd12 -7586 -8164
Derl2 -7840 -7798
Psmc1 -7200 -8230
Psma3 -7262 -7959
Psma6 -6856 -8033
Psmd14 -7260 -7506
Psmd10 -6565 -7185
Psmd1 -6199 -7001
Psmd6 -5729 -7384
Psmb7 -5546 -7294
Psma5 -5426 -7070
Psma4 -5360 -7108
Psma2 -4919 -7328
Psma1 -5114 -6649
Psmb1 -4486 -7543
Psmc2 -4305 -6764
Rps27a -4152 -6449
Psmd7 -3758 -6631

Click HERE to show all gene set members

All member genes
LPS OVA
Derl1 -433 -4413
Derl2 -7840 -7798
Derl3 55 -1345
Erlec1 -8034 -8068
Erlin1 -4638 -2554
Erlin2 -4094 3024
Os9 849 -1749
Psma1 -5114 -6649
Psma2 -4919 -7328
Psma3 -7262 -7959
Psma4 -5360 -7108
Psma5 -5426 -7070
Psma6 -6856 -8033
Psma7 480 -5355
Psmb1 -4486 -7543
Psmb10 2001 -2567
Psmb11 1941 2688
Psmb2 2337 1229
Psmb3 5159 -859
Psmb4 1500 -4093
Psmb5 7081 4123
Psmb6 2733 -1694
Psmb7 -5546 -7294
Psmb8 -3414 -6748
Psmb9 -4244 -3009
Psmc1 -7200 -8230
Psmc2 -4305 -6764
Psmc3 4536 -3114
Psmc4 7156 2302
Psmc5 -127 -4588
Psmc6 -7882 -7903
Psmd1 -6199 -7001
Psmd10 -6565 -7185
Psmd11 -2034 654
Psmd12 -7586 -8164
Psmd13 2546 -1418
Psmd14 -7260 -7506
Psmd2 2201 -102
Psmd3 8279 7100
Psmd4 5882 1499
Psmd5 -2930 -3210
Psmd6 -5729 -7384
Psmd7 -3758 -6631
Psmd8 -81 -6375
Psmd9 3732 179
Psme1 -2094 -3119
Psme2 -3440 -6537
Psme3 -2907 -3340
Psme4 -2016 3543
Psmf1 116 388
Rnf185 -1848 -1753
Rnf5 -580 -6441
Rps27a -4152 -6449
Sel1l -2303 2603
Sem1 942 -3239
Uba52 1246 -3924
Ubb 5594 -1688
Ubc 4950 173
Vcp -2648 -6324



SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL
metric value
setSize 26
pMANOVA 0.00433
p.adjustMANOVA 0.0219
s.dist 0.481
s.LPS 0.303
s.OVA 0.374
p.LPS 0.00752
p.OVA 0.000971



Top 20 genes
Gene LPS OVA
Itpk1 8641 8301
Inppl1 8333 8289
Plcg1 8019 8349
Plch2 7951 8173
Inpp5j 8117 7768
Itpka 7009 5763
Plcb2 5677 6883
Inpp5b 4951 7119
Pld4 6554 5000
Plcb3 7253 4122
Plcg2 5528 5219
Inpp5d 5818 4947
Plcd1 5475 4383
Itpkc 5839 4046
Itpkb 4541 3903
Plcd3 5041 1799
Plce1 152 4798

Click HERE to show all gene set members

All member genes
LPS OVA
Calm1 -7790 -8217
Inpp5b 4951 7119
Inpp5d 5818 4947
Inpp5j 8117 7768
Inppl1 8333 8289
Itpk1 8641 8301
Itpka 7009 5763
Itpkb 4541 3903
Itpkc 5839 4046
Ocrl -1272 5325
Plcb1 -5292 -2015
Plcb2 5677 6883
Plcb3 7253 4122
Plcb4 -4295 -4609
Plcd1 5475 4383
Plcd3 5041 1799
Plcd4 -152 1705
Plce1 152 4798
Plcg1 8019 8349
Plcg2 5528 5219
Plch1 -2999 183
Plch2 7951 8173
Plcz1 -860 -3929
Pld4 6554 5000
Pten -7959 -6625
Synj1 -1885 3391



RUNX3 REGULATES NOTCH SIGNALING
RUNX3 REGULATES NOTCH SIGNALING
metric value
setSize 13
pMANOVA 0.0589
p.adjustMANOVA 0.169
s.dist 0.48
s.LPS 0.293
s.OVA 0.38
p.LPS 0.067
p.OVA 0.0176



Top 20 genes
Gene LPS OVA
Crebbp 7829 8436
Notch1 8135 8109
Jag1 5370 6450
Kat2a 6237 4508
Ep300 3580 7134
Maml3 5015 4296
Maml1 4890 3648
Mamld1 2229 7790
Maml2 1073 3312

Click HERE to show all gene set members

All member genes
LPS OVA
Crebbp 7829 8436
Ep300 3580 7134
Hes1 4433 -5466
Jag1 5370 6450
Kat2a 6237 4508
Kat2b -5130 -319
Maml1 4890 3648
Maml2 1073 3312
Maml3 5015 4296
Mamld1 2229 7790
Notch1 8135 8109
Rbpj -1273 2626
Snw1 -7196 -7751



COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
metric value
setSize 62
pMANOVA 6.69e-06
p.adjustMANOVA 8.51e-05
s.dist 0.48
s.LPS 0.326
s.OVA 0.352
p.LPS 8.86e-06
p.OVA 1.65e-06



Top 20 genes
Gene LPS OVA
Plod3 8446 7668
Plod1 7404 7471
Adamts14 7090 7744
P3h3 7067 7202
P3h1 7143 6950
Colgalt1 7169 6895
Col9a3 6337 7597
P3h2 6124 7363
P4ha2 6065 7206
Serpinh1 8129 5155
Col26a1 5775 6838
Col4a2 6179 6210
Col27a1 5690 5954
Col4a1 5567 5828
Col4a3 3773 7474
Col11a2 5306 4519
Col2a1 4615 5094
Bmp1 5175 4542
Col4a5 4193 5169
Col18a1 5859 3622

Click HERE to show all gene set members

All member genes
LPS OVA
Adamts14 7090 7744
Adamts2 1977 4527
Adamts3 2753 6704
Bmp1 5175 4542
Col11a1 3153 2895
Col11a2 5306 4519
Col12a1 4188 3639
Col13a1 5010 3869
Col14a1 -1845 667
Col15a1 2122 349
Col16a1 3678 4687
Col18a1 5859 3622
Col19a1 1919 5919
Col1a1 6154 1840
Col1a2 2458 -2665
Col20a1 3698 1921
Col22a1 2219 3722
Col23a1 -919 -1768
Col24a1 -1358 -5796
Col25a1 -1585 3157
Col26a1 5775 6838
Col27a1 5690 5954
Col2a1 4615 5094
Col3a1 -3804 -6706
Col4a1 5567 5828
Col4a2 6179 6210
Col4a3 3773 7474
Col4a4 2343 4535
Col4a5 4193 5169
Col5a1 425 3732
Col5a2 1371 2653
Col5a3 1099 2893
Col6a1 1086 3263
Col6a2 -508 2528
Col6a3 3132 5435
Col6a5 1486 1980
Col6a6 -568 4358
Col7a1 2966 3169
Col8a1 952 1337
Col8a2 4071 5011
Col9a1 -1526 -1142
Col9a2 2079 -1024
Col9a3 6337 7597
Colgalt1 7169 6895
Colgalt2 -1840 -1163
Crtap 4058 2341
P3h1 7143 6950
P3h2 6124 7363
P3h3 7067 7202
P4ha1 -1032 -2398
P4ha2 6065 7206
P4ha3 3961 2439
P4hb -599 -4337
Pcolce 7301 66
Pcolce2 -93 2779
Plod1 7404 7471
Plod2 -5502 -5515
Plod3 8446 7668
Ppib 4667 1592
Serpinh1 8129 5155
Tll1 -2465 -1902
Tll2 4692 2629



INTERLEUKIN 37 SIGNALING
INTERLEUKIN 37 SIGNALING
metric value
setSize 17
pMANOVA 0.0189
p.adjustMANOVA 0.0705
s.dist 0.477
s.LPS 0.277
s.OVA 0.389
p.LPS 0.0481
p.OVA 0.00553



Top 20 genes
Gene LPS OVA
Ptpn23 8193 8190
Ptpn5 8552 7781
Ptpn13 7292 7451
Ptpn14 6072 7359
Ptpn11 6126 6039
Stat3 5607 6416
Smad3 5239 6351
Sigirr 6329 3181
Il18bp 3970 4615
Ptpn9 2871 5233
Ptpn6 2598 2582
Ptpn18 1220 2172

Click HERE to show all gene set members

All member genes
LPS OVA
Casp1 -5811 -5384
Il18bp 3970 4615
Ptpn11 6126 6039
Ptpn12 -1236 3672
Ptpn13 7292 7451
Ptpn14 6072 7359
Ptpn18 1220 2172
Ptpn2 -5832 -6004
Ptpn23 8193 8190
Ptpn4 -6584 -5039
Ptpn5 8552 7781
Ptpn6 2598 2582
Ptpn9 2871 5233
Sigirr 6329 3181
Smad3 5239 6351
Stat3 5607 6416
Tbk1 -948 2509



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.4            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] highr_0.11              later_1.3.2             DelayedArray_0.30.1    
## [28] BiocParallel_1.38.0     parallel_4.4.0          R6_2.5.1               
## [31] bslib_0.7.0             stringi_1.8.4           RColorBrewer_1.1-3     
## [34] jquerylib_0.1.4         Rcpp_1.0.12             assertthat_0.2.1       
## [37] knitr_1.47              httpuv_1.6.15           Matrix_1.7-0           
## [40] tidyselect_1.2.1        rstudioapi_0.16.0       abind_1.4-5            
## [43] yaml_2.3.8              codetools_0.2-20        lattice_0.22-6         
## [46] plyr_1.8.9              withr_3.0.0             shiny_1.8.1.1          
## [49] evaluate_0.23           polyclip_1.10-6         ggstats_0.6.0          
## [52] xml2_1.3.6              pillar_1.9.0            KernSmooth_2.23-24     
## [55] generics_0.1.3          munsell_0.5.1           scales_1.3.0           
## [58] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [61] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [64] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [67] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [70] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [73] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [76] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [79] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [82] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report