date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik -3.3814425
0610009E02Rik -0.3557659
0610009L18Rik -0.8507498
0610010K14Rik 1.2510787
0610012G03Rik 3.9729326
0610030E20Rik 0.1581737

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16911
duplicated_genes_present 0
num_profile_genes_in_sets 8289
num_profile_genes_not_in_sets 8622

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 434
num_genesets_included 1170

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
COHESIN LOADING ONTO CHROMATIN 10 3.53e-03 -0.533 0.06070
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.40e-03 -0.533 0.03820
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 1.18e-03 -0.520 0.03700
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.64e-04 0.511 0.01730
CROSSLINKING OF COLLAGEN FIBRILS 15 9.33e-04 0.494 0.03690
TERMINATION OF O GLYCAN BIOSYNTHESIS 11 5.19e-03 0.487 0.07750
PROCESSING AND ACTIVATION OF SUMO 10 8.21e-03 -0.483 0.10100
APOPTOSIS INDUCED DNA FRAGMENTATION 10 8.22e-03 -0.483 0.10100
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.06e-02 0.467 0.11000
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 4.40e-03 0.456 0.06860
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 6.28e-03 -0.456 0.08640
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 5.32e-03 0.446 0.07780
CD28 DEPENDENT VAV1 PATHWAY 11 1.14e-02 -0.441 0.11300
ACTIVATION OF SMO 16 2.79e-03 0.432 0.05530
MITOTIC TELOPHASE CYTOKINESIS 13 1.12e-02 -0.406 0.11200
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.73e-04 -0.403 0.01450
MET ACTIVATES RAP1 AND RAC1 11 2.26e-02 -0.397 0.16500
REPRESSION OF WNT TARGET GENES 14 1.16e-02 0.389 0.11300
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.67e-02 -0.386 0.18100
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 3.52e-02 -0.385 0.21900
CELLULAR HEXOSE TRANSPORT 11 2.92e-02 0.380 0.19300
ACTIVATION OF RAC1 13 1.81e-02 -0.378 0.14400
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 4.30e-03 0.369 0.06860
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.81e-02 0.365 0.14400
SYNAPTIC ADHESION LIKE MOLECULES 21 4.08e-03 0.362 0.06720
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 2.80e-04 0.355 0.01730
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.86e-02 0.351 0.14600
NRAGE SIGNALS DEATH THROUGH JNK 55 8.21e-06 0.348 0.00201
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 7.28e-03 -0.347 0.09680
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.31e-03 0.345 0.04970
MATURATION OF NUCLEOPROTEIN 10 5.99e-02 -0.344 0.29000
EARLY PHASE OF HIV LIFE CYCLE 13 3.38e-02 -0.340 0.21300
SIGNALING BY FGFR4 IN DISEASE 10 6.56e-02 -0.336 0.30400
PRE NOTCH PROCESSING IN GOLGI 18 1.38e-02 0.335 0.12700
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.99e-02 -0.331 0.30800
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.37e-02 -0.327 0.12700
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 9.19e-06 0.326 0.00201
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 5.22e-02 0.324 0.27800
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 35 9.78e-04 0.322 0.03690
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.57e-03 0.322 0.09850
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 1.30e-02 0.321 0.12100
CRMPS IN SEMA3A SIGNALING 16 2.65e-02 0.320 0.18100
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 1.72e-02 -0.316 0.14300
NCAM1 INTERACTIONS 40 6.34e-04 0.312 0.03100
PEXOPHAGY 11 8.01e-02 0.305 0.33400
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 5.74e-02 0.304 0.28700
INSULIN PROCESSING 24 9.89e-03 -0.304 0.10900
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 8.21e-02 0.303 0.33700
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.63e-02 -0.303 0.18100
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 5.90e-02 0.302 0.28800


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
COHESIN LOADING ONTO CHROMATIN 10 3.53e-03 -5.33e-01 0.060700
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.40e-03 -5.33e-01 0.038200
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 1.18e-03 -5.20e-01 0.037000
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.64e-04 5.11e-01 0.017300
CROSSLINKING OF COLLAGEN FIBRILS 15 9.33e-04 4.94e-01 0.036900
TERMINATION OF O GLYCAN BIOSYNTHESIS 11 5.19e-03 4.87e-01 0.077500
PROCESSING AND ACTIVATION OF SUMO 10 8.21e-03 -4.83e-01 0.101000
APOPTOSIS INDUCED DNA FRAGMENTATION 10 8.22e-03 -4.83e-01 0.101000
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.06e-02 4.67e-01 0.110000
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 4.40e-03 4.56e-01 0.068600
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 6.28e-03 -4.56e-01 0.086400
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 5.32e-03 4.46e-01 0.077800
CD28 DEPENDENT VAV1 PATHWAY 11 1.14e-02 -4.41e-01 0.113000
ACTIVATION OF SMO 16 2.79e-03 4.32e-01 0.055300
MITOTIC TELOPHASE CYTOKINESIS 13 1.12e-02 -4.06e-01 0.112000
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.73e-04 -4.03e-01 0.014500
MET ACTIVATES RAP1 AND RAC1 11 2.26e-02 -3.97e-01 0.165000
REPRESSION OF WNT TARGET GENES 14 1.16e-02 3.89e-01 0.113000
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.67e-02 -3.86e-01 0.181000
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 3.52e-02 -3.85e-01 0.219000
CELLULAR HEXOSE TRANSPORT 11 2.92e-02 3.80e-01 0.193000
ACTIVATION OF RAC1 13 1.81e-02 -3.78e-01 0.144000
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 4.30e-03 3.69e-01 0.068600
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.81e-02 3.65e-01 0.144000
SYNAPTIC ADHESION LIKE MOLECULES 21 4.08e-03 3.62e-01 0.067200
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 2.80e-04 3.55e-01 0.017300
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.86e-02 3.51e-01 0.146000
NRAGE SIGNALS DEATH THROUGH JNK 55 8.21e-06 3.48e-01 0.002010
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 7.28e-03 -3.47e-01 0.096800
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.31e-03 3.45e-01 0.049700
MATURATION OF NUCLEOPROTEIN 10 5.99e-02 -3.44e-01 0.290000
EARLY PHASE OF HIV LIFE CYCLE 13 3.38e-02 -3.40e-01 0.213000
SIGNALING BY FGFR4 IN DISEASE 10 6.56e-02 -3.36e-01 0.304000
PRE NOTCH PROCESSING IN GOLGI 18 1.38e-02 3.35e-01 0.127000
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.99e-02 -3.31e-01 0.308000
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.37e-02 -3.27e-01 0.127000
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 9.19e-06 3.26e-01 0.002010
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 5.22e-02 3.24e-01 0.278000
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 35 9.78e-04 3.22e-01 0.036900
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.57e-03 3.22e-01 0.098500
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 1.30e-02 3.21e-01 0.121000
CRMPS IN SEMA3A SIGNALING 16 2.65e-02 3.20e-01 0.181000
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 1.72e-02 -3.16e-01 0.143000
NCAM1 INTERACTIONS 40 6.34e-04 3.12e-01 0.031000
PEXOPHAGY 11 8.01e-02 3.05e-01 0.334000
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 5.74e-02 3.04e-01 0.287000
INSULIN PROCESSING 24 9.89e-03 -3.04e-01 0.109000
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 8.21e-02 3.03e-01 0.337000
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.63e-02 -3.03e-01 0.181000
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 5.90e-02 3.02e-01 0.288000
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 7.61e-03 3.02e-01 0.098500
MET ACTIVATES RAS SIGNALING 10 9.87e-02 -3.02e-01 0.371000
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 8.35e-02 -3.01e-01 0.339000
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 7.41e-02 -2.98e-01 0.313000
PROTEIN UBIQUITINATION 69 2.04e-05 -2.97e-01 0.002390
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 4.31e-03 -2.96e-01 0.068600
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 2.22e-02 2.95e-01 0.165000
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 6.67e-02 2.94e-01 0.305000
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.08e-01 2.94e-01 0.384000
RUNX3 REGULATES NOTCH SIGNALING 13 6.73e-02 2.93e-01 0.305000
RHO GTPASES ACTIVATE IQGAPS 23 1.50e-02 2.93e-01 0.135000
GAP JUNCTION ASSEMBLY 22 1.76e-02 2.92e-01 0.144000
LGI ADAM INTERACTIONS 14 6.08e-02 2.89e-01 0.291000
RETROGRADE NEUROTROPHIN SIGNALLING 13 7.09e-02 2.89e-01 0.310000
COLLAGEN FORMATION 78 1.03e-05 2.89e-01 0.002010
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 5.35e-02 -2.88e-01 0.278000
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 5.36e-02 2.88e-01 0.278000
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 1.70e-02 -2.88e-01 0.143000
SIGNALING BY FLT3 FUSION PROTEINS 18 3.54e-02 -2.86e-01 0.219000
RMTS METHYLATE HISTONE ARGININES 43 1.18e-03 2.86e-01 0.037000
NOTCH HLH TRANSCRIPTION PATHWAY 28 9.67e-03 2.83e-01 0.109000
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 4.60e-02 2.80e-01 0.261000
RHOBTB1 GTPASE CYCLE 23 2.09e-02 -2.78e-01 0.157000
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 8.28e-02 2.78e-01 0.339000
INTERLEUKIN 37 SIGNALING 17 4.84e-02 2.77e-01 0.266000
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.25e-02 2.76e-01 0.209000
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 54 5.00e-04 2.74e-01 0.029300
RECYCLING PATHWAY OF L1 40 2.86e-03 2.73e-01 0.055700
KINESINS 48 1.10e-03 2.72e-01 0.037000
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 4.55e-02 2.72e-01 0.261000
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 8.99e-02 2.72e-01 0.354000
PROTEIN METHYLATION 17 5.41e-02 -2.70e-01 0.278000
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 9.79e-04 -2.70e-01 0.036900
PHASE 2 PLATEAU PHASE 13 9.29e-02 2.69e-01 0.356000
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 9.31e-02 2.69e-01 0.356000
IRE1ALPHA ACTIVATES CHAPERONES 49 1.20e-03 2.68e-01 0.037000
COLLAGEN CHAIN TRIMERIZATION 39 4.01e-03 2.66e-01 0.067100
CARNITINE METABOLISM 14 8.91e-02 2.62e-01 0.354000
METHYLATION 11 1.35e-01 -2.60e-01 0.432000
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 7.74e-03 -2.60e-01 0.098500
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 8.12e-02 2.60e-01 0.336000
TRIGLYCERIDE CATABOLISM 14 9.32e-02 -2.59e-01 0.356000
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 5.84e-02 2.58e-01 0.287000
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 1.11e-01 2.55e-01 0.387000
GAP JUNCTION TRAFFICKING AND REGULATION 34 1.07e-02 2.53e-01 0.110000
REGULATION OF TLR BY ENDOGENOUS LIGAND 12 1.30e-01 -2.52e-01 0.422000
ANCHORING FIBRIL FORMATION 14 1.02e-01 2.52e-01 0.377000
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 5.22e-02 -2.51e-01 0.278000
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 2.27e-04 2.50e-01 0.017300
VLDLR INTERNALISATION AND DEGRADATION 12 1.35e-01 2.49e-01 0.432000
PEPTIDE HORMONE METABOLISM 58 1.06e-03 -2.49e-01 0.037000
HSF1 DEPENDENT TRANSACTIVATION 35 1.11e-02 2.48e-01 0.111000
SIGNALING BY LEPTIN 10 1.78e-01 2.46e-01 0.482000
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 10 1.80e-01 2.45e-01 0.484000
PYRUVATE METABOLISM 27 2.86e-02 -2.43e-01 0.192000
GLUCONEOGENESIS 27 2.89e-02 2.43e-01 0.193000
INTERLEUKIN 12 SIGNALING 37 1.07e-02 -2.43e-01 0.110000
SIGNALING BY BMP 24 4.10e-02 -2.41e-01 0.243000
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.49e-01 -2.41e-01 0.452000
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 1.68e-01 -2.40e-01 0.475000
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 3.07e-03 2.40e-01 0.057500
BIOTIN TRANSPORT AND METABOLISM 11 1.71e-01 2.39e-01 0.475000
RHOBTB3 ATPASE CYCLE 10 1.96e-01 -2.36e-01 0.506000
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 4.51e-02 -2.36e-01 0.261000
BRANCHED CHAIN AMINO ACID CATABOLISM 21 6.09e-02 -2.36e-01 0.291000
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 1.67e-03 2.35e-01 0.042400
SHC MEDIATED CASCADE FGFR4 11 1.79e-01 -2.34e-01 0.484000
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 8.59e-02 2.34e-01 0.344000
REGULATION OF BETA CELL DEVELOPMENT 24 4.77e-02 2.33e-01 0.265000
KERATAN SULFATE BIOSYNTHESIS 23 5.31e-02 2.33e-01 0.278000
REGULATION OF IFNG SIGNALING 13 1.48e-01 -2.31e-01 0.452000
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 1.21e-01 2.31e-01 0.411000
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 4.23e-02 2.30e-01 0.248000
CDC42 GTPASE CYCLE 152 9.93e-07 2.30e-01 0.000581
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 1.23e-01 2.30e-01 0.413000
THE PHOTOTRANSDUCTION CASCADE 21 6.86e-02 -2.30e-01 0.307000
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 37 1.58e-02 2.29e-01 0.138000
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 1.88e-01 2.29e-01 0.495000
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 2.48e-02 2.29e-01 0.175000
P75NTR SIGNALS VIA NF KB 16 1.13e-01 2.29e-01 0.392000
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 2.11e-01 2.29e-01 0.523000
CGMP EFFECTS 15 1.25e-01 -2.29e-01 0.415000
INTERACTION BETWEEN L1 AND ANKYRINS 27 4.00e-02 2.28e-01 0.241000
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 1.39e-04 2.27e-01 0.012500
AGGREPHAGY 34 2.20e-02 2.27e-01 0.164000
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 4.58e-02 2.26e-01 0.261000
DARPP 32 EVENTS 23 6.05e-02 -2.26e-01 0.291000
TIE2 SIGNALING 17 1.07e-01 -2.26e-01 0.384000
PHOSPHORYLATION OF THE APC C 17 1.09e-01 -2.25e-01 0.384000
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 2.20e-01 -2.24e-01 0.534000
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 2.00e-01 2.23e-01 0.512000
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 2.00e-01 -2.23e-01 0.512000
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 7.11e-02 2.22e-01 0.310000
METABOLISM OF POLYAMINES 58 3.47e-03 -2.22e-01 0.060700
DEADENYLATION OF MRNA 25 5.50e-02 -2.22e-01 0.280000
PI 3K CASCADE FGFR4 11 2.03e-01 -2.22e-01 0.516000
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 1.25e-01 -2.21e-01 0.415000
DISEASES OF GLYCOSYLATION 127 1.73e-05 2.21e-01 0.002250
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 1.54e-01 2.20e-01 0.460000
SIGNALLING TO RAS 18 1.06e-01 2.20e-01 0.383000
IRAK4 DEFICIENCY TLR2 4 13 1.71e-01 -2.19e-01 0.475000
SEMA4D IN SEMAPHORIN SIGNALING 24 6.54e-02 2.17e-01 0.304000
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.75e-02 -2.17e-01 0.144000
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 1.03e-01 -2.16e-01 0.377000
G ALPHA 12 13 SIGNALLING EVENTS 74 1.37e-03 2.15e-01 0.038200
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 1.06e-01 -2.14e-01 0.383000
SIGNALING BY PDGFR IN DISEASE 20 9.81e-02 -2.14e-01 0.370000
ECM PROTEOGLYCANS 66 2.74e-03 2.13e-01 0.055200
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 4.71e-03 -2.13e-01 0.072500
REGULATION OF BACH1 ACTIVITY 11 2.22e-01 -2.13e-01 0.535000
KERATAN SULFATE KERATIN METABOLISM 29 4.81e-02 2.12e-01 0.265000
OLFACTORY SIGNALING PATHWAY 30 4.47e-02 -2.12e-01 0.260000
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.56e-01 -2.12e-01 0.462000
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.21e-01 2.11e-01 0.411000
CHONDROITIN SULFATE BIOSYNTHESIS 19 1.11e-01 2.11e-01 0.387000
RAB GERANYLGERANYLATION 59 5.05e-03 -2.11e-01 0.076700
LAMININ INTERACTIONS 28 5.33e-02 2.11e-01 0.278000
INTERLEUKIN 10 SIGNALING 20 1.03e-01 -2.11e-01 0.377000
INTERLEUKIN 20 FAMILY SIGNALING 13 1.89e-01 2.11e-01 0.495000
INITIAL TRIGGERING OF COMPLEMENT 11 2.27e-01 2.10e-01 0.545000
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 1.23e-01 -2.10e-01 0.413000
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 9.64e-02 2.10e-01 0.366000
PURINE CATABOLISM 16 1.49e-01 -2.09e-01 0.452000
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 5.60e-03 -2.09e-01 0.080900
RHOBTB GTPASE CYCLE 35 3.28e-02 -2.08e-01 0.210000
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 1.63e-01 -2.08e-01 0.468000
RHOBTB2 GTPASE CYCLE 23 8.47e-02 -2.08e-01 0.343000
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 8.55e-02 -2.07e-01 0.344000
SYNTHESIS OF PE 13 1.99e-01 2.06e-01 0.512000
ORC1 REMOVAL FROM CHROMATIN 68 3.52e-03 -2.05e-01 0.060700
ELASTIC FIBRE FORMATION 36 3.42e-02 2.04e-01 0.215000
DEGRADATION OF THE EXTRACELLULAR MATRIX 107 2.71e-04 2.04e-01 0.017300
ANTIGEN PROCESSING CROSS PRESENTATION 95 6.36e-04 -2.03e-01 0.031000
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.01e-02 -2.02e-01 0.110000
PYROPTOSIS 21 1.09e-01 -2.02e-01 0.384000
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 1.18e-03 -2.01e-01 0.037000
SUMOYLATION OF INTRACELLULAR RECEPTORS 25 8.17e-02 -2.01e-01 0.337000
S PHASE 155 1.60e-05 -2.01e-01 0.002250
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 2.29e-01 -2.01e-01 0.547000
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 1.79e-02 -2.00e-01 0.144000
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 70 3.90e-03 -2.00e-01 0.066100
INTERFERON ALPHA BETA SIGNALING 52 1.29e-02 -1.99e-01 0.121000
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 1.44e-01 1.99e-01 0.443000
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 1.68e-01 -1.99e-01 0.475000
PLATELET AGGREGATION PLUG FORMATION 32 5.14e-02 1.99e-01 0.277000
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 9.99e-02 1.98e-01 0.375000
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 2.34e-03 -1.98e-01 0.049700
PRE NOTCH EXPRESSION AND PROCESSING 64 6.18e-03 1.98e-01 0.086100
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 2.57e-01 -1.97e-01 0.580000
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 1.27e-01 -1.97e-01 0.417000
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 20 1.28e-01 -1.97e-01 0.418000
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 11 2.61e-01 -1.96e-01 0.585000
INTERLEUKIN 12 FAMILY SIGNALING 44 2.46e-02 -1.96e-01 0.175000
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 1.81e-02 1.95e-01 0.144000
FATTY ACYL COA BIOSYNTHESIS 32 5.77e-02 -1.94e-01 0.287000
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 3.69e-02 1.93e-01 0.226000
O LINKED GLYCOSYLATION 89 1.66e-03 1.93e-01 0.042400
PROCESSING OF SMDT1 16 1.82e-01 -1.93e-01 0.487000
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 2.39e-02 1.93e-01 0.172000
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 1.08e-02 -1.92e-01 0.110000
CHOLESTEROL BIOSYNTHESIS 24 1.04e-01 -1.92e-01 0.380000
GLYCOGEN SYNTHESIS 14 2.14e-01 -1.92e-01 0.526000
EXTRACELLULAR MATRIX ORGANIZATION 241 3.09e-07 1.92e-01 0.000362
INTEGRIN SIGNALING 24 1.05e-01 1.91e-01 0.382000
SIGNALING BY NOTCH2 33 5.80e-02 1.91e-01 0.287000
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 32 6.24e-02 -1.90e-01 0.296000
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 3.08e-03 -1.90e-01 0.057500
HYALURONAN METABOLISM 15 2.02e-01 1.90e-01 0.515000
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 6.77e-02 1.90e-01 0.306000
GLUTAMATE AND GLUTAMINE METABOLISM 13 2.39e-01 1.89e-01 0.561000
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 2.06e-01 -1.89e-01 0.520000
DNA DAMAGE BYPASS 47 2.56e-02 -1.88e-01 0.178000
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 1.36e-01 1.88e-01 0.433000
HDACS DEACETYLATE HISTONES 46 2.77e-02 1.88e-01 0.187000
COLLAGEN DEGRADATION 51 2.05e-02 1.88e-01 0.157000
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.20e-01 1.88e-01 0.410000
STABILIZATION OF P53 55 1.68e-02 -1.87e-01 0.143000
TRANSLESION SYNTHESIS BY POLH 19 1.60e-01 -1.86e-01 0.465000
ASPARTATE AND ASPARAGINE METABOLISM 10 3.07e-01 -1.86e-01 0.647000
FRS MEDIATED FGFR4 SIGNALING 13 2.45e-01 -1.86e-01 0.566000
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 2.12e-01 1.86e-01 0.525000
SIGNALING BY FGFR1 IN DISEASE 32 6.92e-02 -1.86e-01 0.307000
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 9.82e-03 -1.85e-01 0.109000
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 2.00e-01 1.85e-01 0.512000
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 31 7.44e-02 1.85e-01 0.313000
TRP CHANNELS 18 1.75e-01 1.84e-01 0.480000
SIGNALING BY KIT IN DISEASE 20 1.55e-01 -1.84e-01 0.462000
SIGNALING BY ERBB2 ECD MUTANTS 16 2.04e-01 -1.83e-01 0.517000
INTERFERON GAMMA SIGNALING 73 6.82e-03 -1.83e-01 0.092700
G2 M DNA DAMAGE CHECKPOINT 65 1.07e-02 -1.83e-01 0.110000
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 7.31e-02 1.83e-01 0.311000
INOSITOL PHOSPHATE METABOLISM 47 3.03e-02 1.83e-01 0.198000
P75NTR RECRUITS SIGNALLING COMPLEXES 13 2.54e-01 1.83e-01 0.580000
RET SIGNALING 36 5.83e-02 1.82e-01 0.287000
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 30 8.49e-02 -1.82e-01 0.343000
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 26 1.10e-01 1.81e-01 0.385000
GP1B IX V ACTIVATION SIGNALLING 10 3.22e-01 1.81e-01 0.661000
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 6.36e-04 1.81e-01 0.031000
RHOB GTPASE CYCLE 67 1.08e-02 1.80e-01 0.110000
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 2.82e-01 1.79e-01 0.617000
SIGNALING BY HIPPO 20 1.65e-01 -1.79e-01 0.472000
TRANSLESION SYNTHESIS BY POLK 17 2.01e-01 -1.79e-01 0.513000
MITOTIC SPINDLE CHECKPOINT 96 2.45e-03 -1.79e-01 0.051300
DISEASES OF METABOLISM 201 1.24e-05 1.79e-01 0.002080
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 30 9.02e-02 -1.79e-01 0.354000
ORGANIC CATION ANION ZWITTERION TRANSPORT 10 3.28e-01 1.78e-01 0.667000
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 7.19e-02 -1.78e-01 0.311000
MITOCHONDRIAL TRNA AMINOACYLATION 21 1.61e-01 1.77e-01 0.466000
FGFR1 MUTANT RECEPTOR ACTIVATION 25 1.27e-01 -1.76e-01 0.417000
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 1.01e-01 -1.76e-01 0.375000
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 64 1.52e-02 -1.76e-01 0.135000
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 15 2.41e-01 1.75e-01 0.562000
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 3.15e-01 -1.75e-01 0.654000
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 3.24e-02 1.75e-01 0.209000
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.89e-03 -1.75e-01 0.043300
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.19e-02 -1.74e-01 0.114000
DISEASES OF CARBOHYDRATE METABOLISM 29 1.07e-01 1.73e-01 0.384000
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 1.01e-01 1.73e-01 0.375000
DNA METHYLATION 20 1.81e-01 1.73e-01 0.486000
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 3.45e-01 1.72e-01 0.677000
APOPTOTIC EXECUTION PHASE 45 4.58e-02 -1.72e-01 0.261000
MET ACTIVATES PTK2 SIGNALING 29 1.09e-01 1.72e-01 0.384000
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 3.24e-01 1.72e-01 0.664000
NEUREXINS AND NEUROLIGINS 54 2.92e-02 1.72e-01 0.193000
GABA RECEPTOR ACTIVATION 53 3.07e-02 -1.72e-01 0.200000
PHASE 4 RESTING MEMBRANE POTENTIAL 14 2.67e-01 1.71e-01 0.596000
DNA REPLICATION PRE INITIATION 81 7.72e-03 -1.71e-01 0.098500
CELL CYCLE CHECKPOINTS 243 4.44e-06 -1.71e-01 0.001730
PI 3K CASCADE FGFR2 16 2.37e-01 -1.71e-01 0.560000
SYNTHESIS OF PA 29 1.12e-01 1.71e-01 0.388000
DNA REPLICATION 123 1.16e-03 -1.70e-01 0.037000
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 2.40e-01 -1.70e-01 0.561000
HIV TRANSCRIPTION INITIATION 45 4.97e-02 -1.69e-01 0.271000
EUKARYOTIC TRANSLATION INITIATION 114 1.84e-03 -1.69e-01 0.043300
DEATH RECEPTOR SIGNALLING 133 7.87e-04 1.69e-01 0.034100
SUMOYLATION OF DNA METHYLATION PROTEINS 16 2.44e-01 1.68e-01 0.565000
G PROTEIN ACTIVATION 22 1.73e-01 -1.68e-01 0.476000
REGULATED NECROSIS 46 4.94e-02 -1.68e-01 0.270000
NEPHRIN FAMILY INTERACTIONS 22 1.75e-01 1.67e-01 0.479000
BETA CATENIN PHOSPHORYLATION CASCADE 16 2.47e-01 -1.67e-01 0.568000
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 1.67e-01 1.67e-01 0.474000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 24 1.60e-01 -1.66e-01 0.465000
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 6.66e-02 1.66e-01 0.305000
DEGRADATION OF GLI1 BY THE PROTEASOME 58 2.94e-02 -1.65e-01 0.193000
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.23e-01 1.65e-01 0.413000
SIGNALING BY NOTCH3 48 4.79e-02 1.65e-01 0.265000
GAB1 SIGNALOSOME 13 3.03e-01 1.65e-01 0.645000
EFFECTS OF PIP2 HYDROLYSIS 27 1.38e-01 1.65e-01 0.437000
FORMATION OF THE CORNIFIED ENVELOPE 29 1.25e-01 1.65e-01 0.414000
KERATINIZATION 29 1.25e-01 1.65e-01 0.414000
G2 M CHECKPOINTS 135 9.61e-04 -1.65e-01 0.036900
G1 S DNA DAMAGE CHECKPOINTS 66 2.09e-02 -1.65e-01 0.157000
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 1.72e-01 1.64e-01 0.476000
P38MAPK EVENTS 12 3.31e-01 1.62e-01 0.668000
INTERLEUKIN 6 SIGNALING 10 3.75e-01 1.62e-01 0.695000
METABOLISM OF FOLATE AND PTERINES 15 2.78e-01 1.62e-01 0.611000
FORMATION OF INCISION COMPLEX IN GG NER 43 6.72e-02 -1.61e-01 0.305000
MTORC1 MEDIATED SIGNALLING 24 1.72e-01 -1.61e-01 0.476000
ATTENUATION PHASE 25 1.64e-01 1.61e-01 0.469000
DEGRADATION OF AXIN 54 4.15e-02 -1.60e-01 0.245000
COPI MEDIATED ANTEROGRADE TRANSPORT 90 8.67e-03 1.60e-01 0.103000
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 1.84e-01 -1.60e-01 0.490000
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.27e-01 1.60e-01 0.545000
CS DS DEGRADATION 14 3.01e-01 1.60e-01 0.644000
FC EPSILON RECEPTOR FCERI SIGNALING 124 2.17e-03 -1.60e-01 0.047900
TRANSCRIPTIONAL REGULATION BY E2F6 34 1.08e-01 -1.59e-01 0.384000
MUCOPOLYSACCHARIDOSES 11 3.61e-01 1.59e-01 0.695000
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 2.19e-01 -1.59e-01 0.532000
FCERI MEDIATED NF KB ACTIVATION 77 1.60e-02 -1.59e-01 0.139000
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 3.42e-01 1.59e-01 0.675000
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 2.33e-01 -1.58e-01 0.555000
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 9.20e-02 1.58e-01 0.356000
INTERFERON SIGNALING 161 5.55e-04 -1.58e-01 0.030900
KILLING MECHANISMS 10 3.89e-01 1.57e-01 0.708000
SIGNALING BY THE B CELL RECEPTOR BCR 104 5.72e-03 -1.57e-01 0.081600
TBC RABGAPS 43 7.54e-02 1.57e-01 0.316000
DEGRADATION OF DVL 56 4.29e-02 -1.56e-01 0.251000
HS GAG DEGRADATION 21 2.18e-01 1.55e-01 0.532000
AMINE LIGAND BINDING RECEPTORS 29 1.49e-01 1.55e-01 0.452000
DERMATAN SULFATE BIOSYNTHESIS 11 3.75e-01 1.55e-01 0.695000
GLUTATHIONE SYNTHESIS AND RECYCLING 11 3.76e-01 1.54e-01 0.695000
ER QUALITY CONTROL COMPARTMENT ERQC 21 2.21e-01 -1.54e-01 0.535000
INTERLEUKIN 6 FAMILY SIGNALING 20 2.33e-01 1.54e-01 0.555000
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 1.93e-01 -1.54e-01 0.502000
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.36e-02 -1.53e-01 0.170000
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 1.07e-02 -1.53e-01 0.110000
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 3.41e-01 1.52e-01 0.675000
PLATELET ADHESION TO EXPOSED COLLAGEN 11 3.81e-01 -1.52e-01 0.699000
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 31 1.43e-01 1.52e-01 0.441000
MITOTIC G1 PHASE AND G1 S TRANSITION 142 1.81e-03 -1.52e-01 0.043300
SHC MEDIATED CASCADE FGFR1 14 3.28e-01 -1.51e-01 0.667000
FRS MEDIATED FGFR2 SIGNALING 18 2.68e-01 -1.51e-01 0.596000
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.47e-01 1.51e-01 0.678000
REGULATION OF PTEN STABILITY AND ACTIVITY 67 3.31e-02 -1.51e-01 0.211000
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 1.71e-02 -1.51e-01 0.143000
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 2.57e-01 -1.50e-01 0.580000
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 5.62e-02 -1.50e-01 0.284000
HEDGEHOG LIGAND BIOGENESIS 62 4.08e-02 -1.50e-01 0.243000
COMPLEX I BIOGENESIS 56 5.26e-02 -1.50e-01 0.278000
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 5.28e-02 1.50e-01 0.278000
LYSOSPHINGOLIPID AND LPA RECEPTORS 11 3.90e-01 -1.50e-01 0.708000
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 3.01e-01 -1.50e-01 0.644000
CONSTITUTIVE SIGNALING BY EGFRVIII 15 3.16e-01 -1.49e-01 0.655000
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 1.69e-02 1.49e-01 0.143000
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 1.72e-01 -1.49e-01 0.476000
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 8.05e-03 1.48e-01 0.101000
PLASMA LIPOPROTEIN CLEARANCE 26 1.92e-01 1.48e-01 0.502000
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 1.69e-01 1.48e-01 0.475000
GRB2 EVENTS IN ERBB2 SIGNALING 14 3.40e-01 -1.47e-01 0.675000
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 1.27e-03 -1.47e-01 0.038000
NEGATIVE REGULATION OF FLT3 15 3.26e-01 1.46e-01 0.667000
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 2.07e-02 -1.45e-01 0.157000
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 2.07e-02 1.45e-01 0.157000
REDUCTION OF CYTOSOLIC CA LEVELS 12 3.85e-01 -1.45e-01 0.703000
RORA ACTIVATES GENE EXPRESSION 18 2.87e-01 1.45e-01 0.626000
FORMATION OF APOPTOSOME 10 4.28e-01 -1.45e-01 0.738000
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 3.03e-01 1.44e-01 0.645000
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 2.53e-01 -1.44e-01 0.578000
METABOLISM OF FAT SOLUBLE VITAMINS 32 1.59e-01 1.44e-01 0.465000
SEPARATION OF SISTER CHROMATIDS 165 1.57e-03 -1.43e-01 0.041700
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.33e-01 1.43e-01 0.429000
CALNEXIN CALRETICULIN CYCLE 26 2.09e-01 -1.42e-01 0.522000
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 7.29e-02 -1.42e-01 0.311000
TERMINATION OF TRANSLESION DNA SYNTHESIS 31 1.70e-01 -1.42e-01 0.475000
HEME BIOSYNTHESIS 13 3.74e-01 1.42e-01 0.695000
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 3.94e-01 -1.42e-01 0.708000
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 1.40e-01 -1.42e-01 0.439000
SHC1 EVENTS IN ERBB4 SIGNALING 12 3.95e-01 -1.42e-01 0.710000
CD28 CO STIMULATION 30 1.80e-01 -1.42e-01 0.484000
LONG TERM POTENTIATION 23 2.41e-01 1.41e-01 0.562000
PI 3K CASCADE FGFR1 14 3.60e-01 -1.41e-01 0.695000
CELLULAR RESPONSE TO HYPOXIA 72 3.85e-02 -1.41e-01 0.234000
REGULATION OF RAS BY GAPS 67 4.63e-02 -1.41e-01 0.262000
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 85 2.50e-02 1.41e-01 0.175000
RAC1 GTPASE CYCLE 176 1.39e-03 1.40e-01 0.038200
PYRIMIDINE SALVAGE 10 4.44e-01 1.40e-01 0.750000
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.69e-01 -1.39e-01 0.695000
MICRORNA MIRNA BIOGENESIS 24 2.40e-01 1.39e-01 0.561000
SIGNALING BY NOTCH1 75 3.83e-02 1.38e-01 0.233000
RIPK1 MEDIATED REGULATED NECROSIS 25 2.32e-01 -1.38e-01 0.553000
FGFR2 LIGAND BINDING AND ACTIVATION 11 4.29e-01 -1.38e-01 0.738000
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.11e-01 -1.38e-01 0.652000
SENSORY PROCESSING OF SOUND 61 6.28e-02 1.38e-01 0.296000
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 38 1.42e-01 -1.38e-01 0.441000
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 2.55e-01 -1.37e-01 0.580000
MITOTIC METAPHASE AND ANAPHASE 206 7.01e-04 -1.37e-01 0.031600
SODIUM CALCIUM EXCHANGERS 10 4.53e-01 -1.37e-01 0.758000
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.92e-01 -1.37e-01 0.708000
HIV ELONGATION ARREST AND RECOVERY 32 1.81e-01 1.37e-01 0.486000
SEMAPHORIN INTERACTIONS 64 5.93e-02 1.36e-01 0.288000
PHOSPHOLIPID METABOLISM 185 1.40e-03 1.36e-01 0.038200
SELENOAMINO ACID METABOLISM 109 1.41e-02 -1.36e-01 0.128000
FANCONI ANEMIA PATHWAY 36 1.58e-01 1.36e-01 0.465000
ONCOGENE INDUCED SENESCENCE 32 1.84e-01 1.36e-01 0.489000
TCR SIGNALING 102 1.83e-02 -1.35e-01 0.144000
VOLTAGE GATED POTASSIUM CHANNELS 40 1.39e-01 1.35e-01 0.437000
ADHERENS JUNCTIONS INTERACTIONS 29 2.08e-01 -1.35e-01 0.522000
NONSENSE MEDIATED DECAY NMD 109 1.53e-02 -1.35e-01 0.135000
PROLONGED ERK ACTIVATION EVENTS 13 4.02e-01 -1.34e-01 0.717000
CHROMATIN MODIFYING ENZYMES 218 6.79e-04 1.34e-01 0.031600
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 3.70e-01 -1.34e-01 0.695000
G PROTEIN BETA GAMMA SIGNALLING 30 2.05e-01 -1.34e-01 0.518000
MEIOTIC RECOMBINATION 38 1.54e-01 -1.34e-01 0.460000
CLEC7A DECTIN 1 SIGNALING 95 2.45e-02 -1.34e-01 0.175000
C TYPE LECTIN RECEPTORS CLRS 114 1.41e-02 -1.33e-01 0.128000
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 9.31e-02 -1.32e-01 0.356000
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 3.93e-01 1.32e-01 0.708000
PROCESSING OF INTRONLESS PRE MRNAS 19 3.21e-01 -1.32e-01 0.659000
DAP12 INTERACTIONS 29 2.20e-01 -1.32e-01 0.534000
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 7.84e-02 -1.31e-01 0.327000
GLYCOSAMINOGLYCAN METABOLISM 114 1.55e-02 1.31e-01 0.136000
RHOC GTPASE CYCLE 73 5.25e-02 1.31e-01 0.278000
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.80e-01 -1.31e-01 0.484000
SHC MEDIATED CASCADE FGFR3 13 4.14e-01 -1.31e-01 0.726000
CA2 PATHWAY 56 9.04e-02 -1.31e-01 0.354000
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 2.78e-01 1.31e-01 0.611000
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 5.69e-02 -1.31e-01 0.287000
EXTRA NUCLEAR ESTROGEN SIGNALING 65 6.87e-02 -1.31e-01 0.307000
HOST INTERACTIONS OF HIV FACTORS 124 1.21e-02 -1.31e-01 0.115000
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 3.12e-01 1.31e-01 0.653000
EUKARYOTIC TRANSLATION ELONGATION 87 3.69e-02 -1.29e-01 0.226000
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 23 2.83e-01 -1.29e-01 0.618000
DSCAM INTERACTIONS 10 4.83e-01 1.28e-01 0.782000
HCMV EARLY EVENTS 80 4.76e-02 1.28e-01 0.265000
SPRY REGULATION OF FGF SIGNALING 16 3.75e-01 1.28e-01 0.695000
JOSEPHIN DOMAIN DUBS 11 4.63e-01 1.28e-01 0.767000
STIMULI SENSING CHANNELS 74 5.75e-02 1.28e-01 0.287000
L1CAM INTERACTIONS 107 2.26e-02 1.28e-01 0.165000
RHOA GTPASE CYCLE 141 9.10e-03 1.27e-01 0.105000
ASSEMBLY OF THE HIV VIRION 16 3.79e-01 1.27e-01 0.697000
COSTIMULATION BY THE CD28 FAMILY 49 1.24e-01 -1.27e-01 0.414000
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 1.61e-01 1.27e-01 0.466000
INFLUENZA INFECTION 145 8.79e-03 -1.26e-01 0.103000
PLASMA LIPOPROTEIN REMODELING 15 3.99e-01 1.26e-01 0.712000
ER TO GOLGI ANTEROGRADE TRANSPORT 139 1.05e-02 1.26e-01 0.110000
METABOLISM OF PORPHYRINS 19 3.43e-01 1.26e-01 0.676000
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 2.98e-01 1.25e-01 0.639000
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 4.93e-01 1.25e-01 0.782000
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 4.19e-01 1.25e-01 0.728000
G ALPHA S SIGNALLING EVENTS 98 3.49e-02 1.23e-01 0.218000
METABOLISM OF COFACTORS 18 3.66e-01 -1.23e-01 0.695000
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 3.18e-01 -1.23e-01 0.657000
ACYL CHAIN REMODELLING OF PS 14 4.27e-01 1.23e-01 0.738000
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 1.30e-01 1.23e-01 0.422000
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 3.20e-01 -1.23e-01 0.659000
FRS MEDIATED FGFR1 SIGNALING 16 3.97e-01 -1.22e-01 0.710000
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 3.70e-01 -1.22e-01 0.695000
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 80 5.92e-02 -1.22e-01 0.288000
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 3.33e-01 -1.22e-01 0.668000
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 1.06e-01 1.22e-01 0.383000
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 5.05e-01 -1.22e-01 0.786000
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 4.86e-01 -1.21e-01 0.782000
TRAFFICKING OF AMPA RECEPTORS 31 2.43e-01 1.21e-01 0.564000
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 3.05e-01 1.21e-01 0.646000
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 4.18e-01 1.21e-01 0.728000
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 44 1.66e-01 1.21e-01 0.472000
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 4.89e-01 1.21e-01 0.782000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 3.76e-01 -1.21e-01 0.695000
MISMATCH REPAIR 14 4.35e-01 -1.20e-01 0.744000
PI 3K CASCADE FGFR3 13 4.52e-01 -1.20e-01 0.758000
GLUCOSE METABOLISM 80 6.28e-02 1.20e-01 0.296000
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 2.39e-01 1.20e-01 0.561000
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 6.85e-02 1.20e-01 0.307000
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 4.72e-01 1.20e-01 0.774000
ENOS ACTIVATION 11 4.91e-01 -1.20e-01 0.782000
IRON UPTAKE AND TRANSPORT 51 1.41e-01 -1.19e-01 0.441000
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.76e-01 1.19e-01 0.778000
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 1.42e-01 -1.19e-01 0.441000
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 3.97e-01 1.19e-01 0.710000
OXIDATIVE STRESS INDUCED SENESCENCE 78 7.00e-02 1.19e-01 0.308000
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 3.71e-01 -1.19e-01 0.695000
CRISTAE FORMATION 31 2.56e-01 -1.18e-01 0.580000
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 4.62e-01 1.18e-01 0.767000
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 4.15e-01 1.18e-01 0.728000
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 4.65e-01 1.17e-01 0.769000
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 5.02e-01 1.17e-01 0.786000
OTHER SEMAPHORIN INTERACTIONS 19 3.81e-01 1.16e-01 0.699000
MEIOSIS 64 1.09e-01 -1.16e-01 0.384000
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 4.53e-01 -1.16e-01 0.758000
SIGNALING BY ERBB2 IN CANCER 24 3.27e-01 -1.16e-01 0.667000
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 168 9.80e-03 1.16e-01 0.109000
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 5.27e-01 1.16e-01 0.805000
REGULATION OF TNFR1 SIGNALING 34 2.44e-01 1.16e-01 0.565000
PEROXISOMAL LIPID METABOLISM 26 3.10e-01 -1.15e-01 0.649000
HIV INFECTION 220 3.36e-03 -1.15e-01 0.060600
NETRIN 1 SIGNALING 48 1.70e-01 1.15e-01 0.475000
HDMS DEMETHYLATE HISTONES 27 3.04e-01 1.14e-01 0.645000
SIGNALING BY ERBB4 56 1.39e-01 -1.14e-01 0.437000
FCERI MEDIATED MAPK ACTIVATION 28 2.95e-01 -1.14e-01 0.638000
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 9.24e-02 -1.14e-01 0.356000
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 45 1.87e-01 -1.14e-01 0.494000
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.16e-01 -1.14e-01 0.655000
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.69e-01 -1.14e-01 0.475000
DISEASES OF DNA REPAIR 11 5.16e-01 -1.13e-01 0.795000
DEADENYLATION DEPENDENT MRNA DECAY 55 1.49e-01 -1.12e-01 0.452000
O LINKED GLYCOSYLATION OF MUCINS 42 2.08e-01 1.12e-01 0.522000
INFLAMMASOMES 19 3.97e-01 -1.12e-01 0.710000
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 4.83e-01 1.12e-01 0.782000
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 16 4.39e-01 1.12e-01 0.744000
RESPIRATORY ELECTRON TRANSPORT 102 5.13e-02 -1.12e-01 0.277000
SULFUR AMINO ACID METABOLISM 22 3.65e-01 1.12e-01 0.695000
SLC MEDIATED TRANSMEMBRANE TRANSPORT 186 8.73e-03 1.12e-01 0.103000
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 5.22e-01 -1.12e-01 0.801000
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 1.64e-01 1.11e-01 0.470000
METABOLISM OF CARBOHYDRATES 257 2.16e-03 1.11e-01 0.047900
SIGNALING BY ROBO RECEPTORS 206 6.05e-03 -1.11e-01 0.085300
RESOLUTION OF SISTER CHROMATID COHESION 101 5.40e-02 -1.11e-01 0.278000
SHC1 EVENTS IN EGFR SIGNALING 10 5.48e-01 -1.10e-01 0.812000
HATS ACETYLATE HISTONES 92 6.92e-02 1.10e-01 0.307000
ABC TRANSPORTER DISORDERS 69 1.15e-01 -1.10e-01 0.398000
PROGRAMMED CELL DEATH 188 9.88e-03 -1.09e-01 0.109000
MAP2K AND MAPK ACTIVATION 36 2.58e-01 1.09e-01 0.581000
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 37 2.56e-01 -1.08e-01 0.580000
PENTOSE PHOSPHATE PATHWAY 13 5.02e-01 -1.07e-01 0.786000
ERKS ARE INACTIVATED 13 5.03e-01 1.07e-01 0.786000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 3.74e-01 -1.07e-01 0.695000
PI METABOLISM 79 1.01e-01 1.07e-01 0.375000
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 3.47e-01 1.07e-01 0.678000
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 4.92e-01 1.06e-01 0.782000
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 4.23e-01 -1.06e-01 0.734000
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.67e-02 -1.06e-01 0.143000
INTEGRATION OF ENERGY METABOLISM 97 7.23e-02 1.06e-01 0.311000
UNFOLDED PROTEIN RESPONSE UPR 85 9.29e-02 1.05e-01 0.356000
RHO GTPASES ACTIVATE NADPH OXIDASES 18 4.43e-01 1.05e-01 0.750000
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 1.01e-01 -1.04e-01 0.375000
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 5.15e-01 -1.04e-01 0.795000
PERK REGULATES GENE EXPRESSION 28 3.40e-01 -1.04e-01 0.675000
PKMTS METHYLATE HISTONE LYSINES 48 2.13e-01 1.04e-01 0.525000
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.70e-01 -1.04e-01 0.829000
PHASE II CONJUGATION OF COMPOUNDS 61 1.62e-01 -1.04e-01 0.467000
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 62 1.59e-01 -1.04e-01 0.465000
G0 AND EARLY G1 25 3.71e-01 -1.03e-01 0.695000
FRS MEDIATED FGFR3 SIGNALING 15 4.89e-01 -1.03e-01 0.782000
GLYCOGEN STORAGE DISEASES 12 5.36e-01 1.03e-01 0.811000
ACTIVATION OF MATRIX METALLOPROTEINASES 15 4.90e-01 1.03e-01 0.782000
REGULATED PROTEOLYSIS OF P75NTR 12 5.37e-01 1.03e-01 0.811000
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 1.50e-01 1.02e-01 0.453000
METALLOPROTEASE DUBS 26 3.66e-01 -1.02e-01 0.695000
HCMV INFECTION 103 7.31e-02 1.02e-01 0.311000
APOPTOSIS 166 2.33e-02 -1.02e-01 0.169000
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 5.77e-01 -1.02e-01 0.832000
FCERI MEDIATED CA 2 MOBILIZATION 26 3.69e-01 -1.02e-01 0.695000
TRANSLATION 286 3.25e-03 -1.01e-01 0.059500
TRANSCRIPTIONAL REGULATION BY RUNX2 111 6.58e-02 -1.01e-01 0.304000
REPRODUCTION 76 1.28e-01 -1.01e-01 0.418000
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 3.32e-01 -1.01e-01 0.668000
EPHRIN SIGNALING 19 4.48e-01 1.01e-01 0.754000
CARDIAC CONDUCTION 108 7.21e-02 1.00e-01 0.311000
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 5.46e-02 -9.96e-02 0.279000
RND3 GTPASE CYCLE 38 2.88e-01 9.96e-02 0.627000
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 15 5.05e-01 9.94e-02 0.786000
LYSINE CATABOLISM 10 5.87e-01 9.92e-02 0.835000
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 2.35e-01 9.91e-02 0.557000
NEGATIVE REGULATION OF MAPK PATHWAY 42 2.68e-01 9.88e-02 0.596000
SIGNALING BY FGFR2 IN DISEASE 36 3.05e-01 -9.88e-02 0.646000
INACTIVATION OF CSF3 G CSF SIGNALING 24 4.03e-01 -9.87e-02 0.717000
TNF SIGNALING 43 2.64e-01 9.84e-02 0.592000
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 5.40e-01 9.82e-02 0.811000
LAGGING STRAND SYNTHESIS 20 4.47e-01 -9.81e-02 0.754000
RND2 GTPASE CYCLE 38 2.97e-01 9.78e-02 0.639000
MRNA SPLICING 188 2.10e-02 -9.78e-02 0.157000
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 5.94e-01 9.74e-02 0.838000
RHOH GTPASE CYCLE 37 3.06e-01 -9.72e-02 0.647000
PLASMA LIPOPROTEIN ASSEMBLY 11 5.77e-01 -9.72e-02 0.832000
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 3.57e-01 9.72e-02 0.694000
RRNA PROCESSING 194 2.00e-02 -9.70e-02 0.156000
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 2.70e-01 9.62e-02 0.599000
DISEASES OF MITOTIC CELL CYCLE 37 3.14e-01 -9.58e-02 0.654000
TRANS GOLGI NETWORK VESICLE BUDDING 69 1.69e-01 -9.57e-02 0.475000
CELLULAR RESPONSE TO STARVATION 145 4.71e-02 -9.56e-02 0.265000
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 1.32e-01 9.56e-02 0.428000
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.15e-02 -9.55e-02 0.113000
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 4.38e-01 -9.54e-02 0.744000
SIGNAL AMPLIFICATION 30 3.66e-01 -9.53e-02 0.695000
TRANSCRIPTION OF THE HIV GENOME 67 1.78e-01 -9.53e-02 0.482000
SIGNALING BY CSF3 G CSF 29 3.75e-01 -9.52e-02 0.695000
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 344 2.54e-03 -9.49e-02 0.052100
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 2.94e-01 9.48e-02 0.635000
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 5.86e-01 -9.48e-02 0.835000
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.69e-01 9.47e-02 0.695000
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 4.76e-01 9.45e-02 0.778000
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 5.13e-01 -9.44e-02 0.795000
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 63 1.95e-01 -9.44e-02 0.506000
ZINC TRANSPORTERS 16 5.18e-01 -9.35e-02 0.797000
SIGNALING BY PDGF 57 2.23e-01 9.34e-02 0.536000
MAPK6 MAPK4 SIGNALING 84 1.39e-01 -9.34e-02 0.437000
INTRA GOLGI TRAFFIC 43 2.89e-01 9.34e-02 0.627000
PREGNENOLONE BIOSYNTHESIS 12 5.77e-01 9.31e-02 0.832000
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 5.62e-01 9.28e-02 0.827000
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 1.23e-01 -9.25e-02 0.413000
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 4.97e-01 -9.24e-02 0.784000
RUNX2 REGULATES BONE DEVELOPMENT 29 3.90e-01 9.22e-02 0.708000
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 2.65e-01 9.21e-02 0.592000
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 1.53e-01 9.20e-02 0.459000
ION CHANNEL TRANSPORT 139 6.30e-02 9.14e-02 0.296000
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 2.10e-01 9.13e-02 0.523000
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 4.92e-01 -9.11e-02 0.782000
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 3.39e-01 -9.09e-02 0.675000
SELECTIVE AUTOPHAGY 71 1.87e-01 9.06e-02 0.494000
DNA DAMAGE RECOGNITION IN GG NER 38 3.35e-01 9.05e-02 0.669000
METAL ION SLC TRANSPORTERS 25 4.34e-01 -9.04e-02 0.744000
M PHASE 339 4.39e-03 -9.02e-02 0.068600
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 4.18e-01 9.01e-02 0.728000
CYCLIN D ASSOCIATED EVENTS IN G1 45 2.96e-01 -9.00e-02 0.639000
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 101 1.19e-01 8.99e-02 0.409000
METABOLISM OF RNA 644 1.08e-04 -8.98e-02 0.010600
SIGNALING BY PTK6 50 2.72e-01 8.98e-02 0.602000
PINK1 PRKN MEDIATED MITOPHAGY 22 4.66e-01 -8.97e-02 0.770000
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 3.75e-01 -8.93e-02 0.695000
ION HOMEOSTASIS 49 2.80e-01 8.93e-02 0.613000
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 4.79e-01 8.92e-02 0.781000
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 3.91e-01 8.91e-02 0.708000
PROLACTIN RECEPTOR SIGNALING 11 6.11e-01 -8.86e-02 0.845000
PHASE 0 RAPID DEPOLARISATION 29 4.10e-01 8.84e-02 0.724000
METABOLISM OF AMINO ACIDS AND DERIVATIVES 314 7.21e-03 -8.84e-02 0.096800
FLT3 SIGNALING IN DISEASE 27 4.27e-01 -8.83e-02 0.738000
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 6.30e-01 8.81e-02 0.859000
INTERLEUKIN 7 SIGNALING 20 4.96e-01 8.80e-02 0.784000
CELL CYCLE 593 2.75e-04 -8.78e-02 0.017300
PURINE SALVAGE 12 5.99e-01 -8.78e-02 0.838000
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 2.76e-01 8.73e-02 0.610000
OTHER INTERLEUKIN SIGNALING 19 5.13e-01 8.67e-02 0.795000
AMYLOID FIBER FORMATION 57 2.59e-01 8.64e-02 0.584000
SIGNALING BY BRAF AND RAF FUSIONS 60 2.52e-01 8.55e-02 0.577000
SIGNALING BY TGFB FAMILY MEMBERS 96 1.50e-01 -8.52e-02 0.452000
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 4.81e-01 -8.50e-02 0.781000
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 4.37e-01 8.49e-02 0.744000
TELOMERE C STRAND SYNTHESIS INITIATION 13 5.96e-01 -8.48e-02 0.838000
G1 S SPECIFIC TRANSCRIPTION 26 4.54e-01 -8.48e-02 0.758000
ONCOGENIC MAPK SIGNALING 77 1.99e-01 8.47e-02 0.512000
SIGNALING BY NTRKS 129 9.73e-02 8.46e-02 0.368000
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 5.46e-01 -8.46e-02 0.811000
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.26e-01 8.40e-02 0.805000
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.42e-01 -8.39e-02 0.563000
FORMATION OF THE EARLY ELONGATION COMPLEX 33 4.06e-01 8.37e-02 0.719000
CELL CYCLE MITOTIC 475 1.87e-03 -8.36e-02 0.043300
GAP JUNCTION DEGRADATION 11 6.31e-01 8.36e-02 0.859000
DAP12 SIGNALING 24 4.80e-01 -8.33e-02 0.781000
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 4.62e-01 -8.33e-02 0.767000
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 3.52e-01 -8.31e-02 0.686000
NUCLEOBASE CATABOLISM 31 4.24e-01 -8.31e-02 0.734000
RESOLUTION OF D LOOP STRUCTURES 30 4.32e-01 -8.30e-02 0.743000
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 5.23e-01 8.25e-02 0.802000
APOPTOTIC FACTOR MEDIATED RESPONSE 18 5.46e-01 -8.21e-02 0.811000
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 5.60e-01 8.17e-02 0.826000
INTEGRIN CELL SURFACE INTERACTIONS 71 2.34e-01 8.17e-02 0.556000
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 6.24e-01 8.17e-02 0.856000
VEGFR2 MEDIATED CELL PROLIFERATION 19 5.39e-01 -8.15e-02 0.811000
RHO GTPASES ACTIVATE CIT 18 5.50e-01 8.14e-02 0.814000
TRANSCRIPTIONAL REGULATION BY VENTX 35 4.05e-01 8.13e-02 0.719000
MUSCLE CONTRACTION 163 7.41e-02 8.12e-02 0.313000
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 5.87e-01 -8.10e-02 0.835000
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 1.92e-01 -8.10e-02 0.502000
INWARDLY RECTIFYING K CHANNELS 31 4.35e-01 -8.09e-02 0.744000
ACYL CHAIN REMODELLING OF PG 10 6.58e-01 -8.08e-02 0.878000
METABOLISM OF VITAMINS AND COFACTORS 150 8.84e-02 8.07e-02 0.353000
GLUCAGON TYPE LIGAND RECEPTORS 25 4.85e-01 -8.06e-02 0.782000
DAG AND IP3 SIGNALING 40 3.79e-01 8.05e-02 0.697000
PECAM1 INTERACTIONS 12 6.30e-01 8.02e-02 0.859000
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 5.15e-01 8.02e-02 0.795000
INTERLEUKIN 1 SIGNALING 96 1.75e-01 -8.02e-02 0.479000
LDL CLEARANCE 16 5.79e-01 8.01e-02 0.832000
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 4.89e-01 -7.99e-02 0.782000
GLYCOSPHINGOLIPID METABOLISM 39 3.88e-01 7.98e-02 0.708000
INSULIN RECEPTOR RECYCLING 20 5.37e-01 -7.97e-02 0.811000
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 4.69e-01 -7.91e-02 0.772000
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 1.58e-01 7.91e-02 0.465000
GOLGI TO ER RETROGRADE TRANSPORT 119 1.37e-01 7.90e-02 0.435000
RAP1 SIGNALLING 15 5.97e-01 -7.89e-02 0.838000
HIV LIFE CYCLE 142 1.05e-01 -7.88e-02 0.382000
CYTOKINE SIGNALING IN IMMUNE SYSTEM 544 1.78e-03 -7.86e-02 0.043300
CD209 DC SIGN SIGNALING 18 5.64e-01 -7.85e-02 0.827000
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 2.14e-01 -7.85e-02 0.526000
CELL CELL COMMUNICATION 107 1.61e-01 7.84e-02 0.466000
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 2.47e-01 -7.79e-02 0.568000
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 6.41e-01 7.79e-02 0.867000
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 5.18e-01 -7.78e-02 0.797000
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 2.16e-01 7.77e-02 0.529000
INTERLEUKIN 35 SIGNALLING 10 6.74e-01 -7.69e-02 0.881000
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 5.64e-01 -7.64e-02 0.827000
SIGNALING BY GPCR 462 5.23e-03 7.60e-02 0.077500
ERK MAPK TARGETS 22 5.39e-01 7.57e-02 0.811000
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 6.00e-01 -7.57e-02 0.838000
NONHOMOLOGOUS END JOINING NHEJ 43 3.92e-01 -7.55e-02 0.708000
SHC1 EVENTS IN ERBB2 SIGNALING 20 5.61e-01 -7.50e-02 0.827000
RHO GTPASE CYCLE 422 8.56e-03 7.48e-02 0.103000
RNA POLYMERASE II TRANSCRIPTION 1085 3.97e-05 -7.44e-02 0.004220
RRNA PROCESSING IN THE MITOCHONDRION 10 6.84e-01 -7.44e-02 0.884000
MITOTIC PROMETAPHASE 176 8.92e-02 -7.44e-02 0.354000
SIGNALING BY NTRK3 TRKC 17 5.98e-01 7.39e-02 0.838000
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 6.72e-01 7.37e-02 0.881000
HCMV LATE EVENTS 65 3.07e-01 7.33e-02 0.647000
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 3.32e-01 7.30e-02 0.668000
RHO GTPASES ACTIVATE KTN1 11 6.76e-01 -7.27e-02 0.881000
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 3.35e-01 -7.25e-02 0.670000
CONDENSATION OF PROPHASE CHROMOSOMES 27 5.14e-01 -7.25e-02 0.795000
NEGATIVE REGULATION OF MET ACTIVITY 21 5.66e-01 -7.23e-02 0.827000
REGULATION OF PTEN GENE TRANSCRIPTION 58 3.42e-01 7.21e-02 0.675000
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 4.80e-01 -7.21e-02 0.781000
GENERATION OF SECOND MESSENGER MOLECULES 19 5.87e-01 -7.21e-02 0.835000
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 3.31e-01 7.20e-02 0.668000
KERATAN SULFATE DEGRADATION 11 6.80e-01 7.19e-02 0.882000
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 3.40e-01 7.18e-02 0.675000
ACTIVATION OF BH3 ONLY PROTEINS 30 4.97e-01 -7.16e-02 0.784000
NGF STIMULATED TRANSCRIPTION 37 4.54e-01 7.12e-02 0.758000
EPH EPHRIN SIGNALING 92 2.39e-01 7.11e-02 0.561000
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 4.05e-02 -7.06e-02 0.243000
SIGNALING BY HEDGEHOG 142 1.49e-01 7.03e-02 0.452000
SYNTHESIS OF PC 25 5.46e-01 6.98e-02 0.811000
PLATELET HOMEOSTASIS 78 2.89e-01 -6.94e-02 0.627000
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 31 5.04e-01 6.94e-02 0.786000
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 5.65e-01 -6.93e-02 0.827000
TRNA AMINOACYLATION 42 4.39e-01 6.91e-02 0.744000
INTERLEUKIN RECEPTOR SHC SIGNALING 20 5.93e-01 6.91e-02 0.838000
SIGNALING BY SCF KIT 41 4.44e-01 -6.91e-02 0.750000
SIGNALING BY EGFR 46 4.18e-01 6.90e-02 0.728000
CELLULAR SENESCENCE 141 1.58e-01 6.89e-02 0.465000
PEROXISOMAL PROTEIN IMPORT 57 3.69e-01 -6.89e-02 0.695000
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 7.06e-01 -6.88e-02 0.895000
GLYCOLYSIS 66 3.34e-01 6.88e-02 0.669000
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 6.24e-01 6.87e-02 0.856000
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 3.46e-01 -6.87e-02 0.678000
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 5.79e-01 6.84e-02 0.832000
UB SPECIFIC PROCESSING PROTEASES 169 1.28e-01 -6.80e-02 0.418000
SUMOYLATION 161 1.37e-01 -6.80e-02 0.435000
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 5.73e-01 -6.79e-02 0.831000
NEURONAL SYSTEM 366 2.66e-02 6.76e-02 0.181000
CELLULAR RESPONSE TO CHEMICAL STRESS 150 1.53e-01 -6.76e-02 0.460000
SIGNALING BY ERYTHROPOIETIN 24 5.67e-01 6.75e-02 0.827000
RESPONSE OF MTB TO PHAGOCYTOSIS 21 5.94e-01 6.72e-02 0.838000
MET PROMOTES CELL MOTILITY 39 4.69e-01 6.70e-02 0.772000
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 6.43e-01 6.68e-02 0.870000
RAS PROCESSING 24 5.71e-01 -6.68e-02 0.829000
CYTOPROTECTION BY HMOX1 120 2.09e-01 -6.64e-02 0.522000
INTRAFLAGELLAR TRANSPORT 50 4.18e-01 6.62e-02 0.728000
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 4.59e-01 6.60e-02 0.765000
RHOJ GTPASE CYCLE 54 4.04e-01 -6.57e-02 0.718000
POLYMERASE SWITCHING 14 6.70e-01 -6.57e-02 0.881000
TRIGLYCERIDE METABOLISM 23 5.87e-01 -6.54e-02 0.835000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 6.16e-01 -6.49e-02 0.849000
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 6.99e-01 -6.45e-02 0.891000
SIGNALING BY FGFR IN DISEASE 55 4.08e-01 -6.45e-02 0.722000
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 7.24e-01 -6.44e-02 0.896000
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 7.24e-01 -6.44e-02 0.896000
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 5.42e-01 -6.44e-02 0.811000
AUTOPHAGY 137 1.94e-01 6.43e-02 0.505000
ERBB2 ACTIVATES PTK6 SIGNALING 10 7.25e-01 6.43e-02 0.896000
PLATELET CALCIUM HOMEOSTASIS 27 5.64e-01 6.41e-02 0.827000
SIGNALING BY NOTCH4 83 3.14e-01 -6.39e-02 0.654000
LATE ENDOSOMAL MICROAUTOPHAGY 30 5.45e-01 6.38e-02 0.811000
N GLYCAN ANTENNAE ELONGATION 15 6.69e-01 6.37e-02 0.881000
CHROMOSOME MAINTENANCE 101 2.71e-01 -6.34e-02 0.601000
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 6.76e-01 -6.24e-02 0.881000
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 6.98e-01 6.22e-02 0.891000
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 622 8.61e-03 6.20e-02 0.103000
PI3K EVENTS IN ERBB2 SIGNALING 14 6.88e-01 -6.19e-02 0.885000
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 7.23e-01 6.17e-02 0.896000
ANTIMICROBIAL PEPTIDES 12 7.11e-01 6.17e-02 0.896000
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 5.95e-01 -6.15e-02 0.838000
EGFR DOWNREGULATION 27 5.81e-01 6.14e-02 0.832000
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 5.88e-01 -6.14e-02 0.835000
DEVELOPMENTAL BIOLOGY 813 3.09e-03 6.14e-02 0.057500
NEDDYLATION 218 1.20e-01 -6.12e-02 0.411000
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 4.89e-01 -6.10e-02 0.782000
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 143 2.11e-01 -6.06e-02 0.524000
ADAPTIVE IMMUNE SYSTEM 599 1.18e-02 -6.05e-02 0.114000
SUMOYLATION OF TRANSCRIPTION FACTORS 16 6.76e-01 -6.04e-02 0.881000
FOXO MEDIATED TRANSCRIPTION 57 4.37e-01 -5.96e-02 0.744000
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 89 3.32e-01 5.96e-02 0.668000
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 4.18e-01 5.95e-02 0.728000
IRAK1 RECRUITS IKK COMPLEX 14 7.00e-01 5.94e-02 0.892000
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 5.44e-01 -5.93e-02 0.811000
POTENTIAL THERAPEUTICS FOR SARS 77 3.72e-01 5.88e-02 0.695000
ASPARAGINE N LINKED GLYCOSYLATION 282 9.02e-02 5.88e-02 0.354000
SIGNALING BY NODAL 16 6.86e-01 5.84e-02 0.884000
PROTEIN LOCALIZATION 156 2.09e-01 -5.84e-02 0.522000
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 5.56e-01 -5.83e-02 0.822000
ERYTHROPOIETIN ACTIVATES RAS 13 7.17e-01 -5.80e-02 0.896000
REGULATION OF IFNA SIGNALING 12 7.28e-01 5.80e-02 0.897000
ERBB2 REGULATES CELL MOTILITY 13 7.20e-01 -5.75e-02 0.896000
TP53 REGULATES METABOLIC GENES 85 3.64e-01 -5.70e-02 0.695000
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 7.33e-01 5.68e-02 0.900000
RHOD GTPASE CYCLE 50 4.88e-01 -5.68e-02 0.782000
CLASS B 2 SECRETIN FAMILY RECEPTORS 70 4.12e-01 5.67e-02 0.726000
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 7.56e-01 -5.67e-02 0.910000
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 7.24e-01 -5.65e-02 0.896000
TNFR2 NON CANONICAL NF KB PATHWAY 83 3.74e-01 -5.65e-02 0.695000
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 7.36e-01 -5.63e-02 0.900000
MTOR SIGNALLING 40 5.39e-01 -5.62e-02 0.811000
SIGNALING BY FGFR1 42 5.29e-01 -5.62e-02 0.807000
DNA STRAND ELONGATION 32 5.85e-01 -5.59e-02 0.835000
METABOLISM OF NUCLEOTIDES 92 3.56e-01 -5.58e-02 0.692000
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 16 6.99e-01 -5.58e-02 0.891000
TRAF6 MEDIATED NF KB ACTIVATION 22 6.51e-01 5.57e-02 0.872000
INTRINSIC PATHWAY FOR APOPTOSIS 52 4.87e-01 -5.57e-02 0.782000
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 20 6.67e-01 -5.56e-02 0.881000
SIGNALING BY ACTIVIN 12 7.39e-01 -5.56e-02 0.902000
VIRAL MESSENGER RNA SYNTHESIS 42 5.33e-01 5.56e-02 0.810000
ION TRANSPORT BY P TYPE ATPASES 48 5.06e-01 5.55e-02 0.786000
POTASSIUM CHANNELS 90 3.63e-01 5.55e-02 0.695000
OPIOID SIGNALLING 86 3.76e-01 -5.52e-02 0.695000
RHOF GTPASE CYCLE 40 5.46e-01 -5.52e-02 0.811000
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 7.51e-01 5.51e-02 0.906000
PI3K AKT SIGNALING IN CANCER 87 3.76e-01 5.50e-02 0.695000
NEUTROPHIL DEGRANULATION 384 6.71e-02 -5.46e-02 0.305000
THE NLRP3 INFLAMMASOME 15 7.17e-01 -5.41e-02 0.896000
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 6.02e-01 -5.41e-02 0.838000
SIGNALING BY NOTCH 189 2.01e-01 5.40e-02 0.513000
PARASITE INFECTION 54 4.93e-01 5.39e-02 0.782000
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 6.48e-01 5.39e-02 0.871000
RHOV GTPASE CYCLE 32 5.98e-01 -5.38e-02 0.838000
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 110 3.32e-01 5.35e-02 0.668000
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 7.48e-01 5.35e-02 0.905000
MRNA SPLICING MINOR PATHWAY 52 5.05e-01 5.34e-02 0.786000
INTERLEUKIN 2 FAMILY SIGNALING 32 6.01e-01 5.34e-02 0.838000
SIGNALING BY INSULIN RECEPTOR 61 4.72e-01 -5.33e-02 0.774000
OVARIAN TUMOR DOMAIN PROTEASES 36 5.80e-01 -5.33e-02 0.832000
MAPK FAMILY SIGNALING CASCADES 286 1.22e-01 5.33e-02 0.413000
NUCLEOTIDE SALVAGE 21 6.75e-01 5.29e-02 0.881000
RAB REGULATION OF TRAFFICKING 119 3.20e-01 5.28e-02 0.659000
CTLA4 INHIBITORY SIGNALING 20 6.83e-01 -5.28e-02 0.884000
MHC CLASS II ANTIGEN PRESENTATION 102 3.58e-01 5.28e-02 0.694000
MITOCHONDRIAL TRANSLATION 93 3.82e-01 -5.25e-02 0.699000
CHEMOKINE RECEPTORS BIND CHEMOKINES 17 7.08e-01 -5.24e-02 0.895000
MITOTIC G2 G2 M PHASES 186 2.18e-01 -5.24e-02 0.532000
MITOPHAGY 29 6.27e-01 -5.22e-02 0.857000
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 7.38e-01 -5.17e-02 0.902000
HEME SIGNALING 45 5.49e-01 -5.17e-02 0.813000
COPII MEDIATED VESICLE TRANSPORT 64 4.75e-01 5.16e-02 0.778000
MITOTIC PROPHASE 94 3.88e-01 -5.15e-02 0.708000
SIGNALING BY ERBB2 47 5.43e-01 -5.13e-02 0.811000
IRS MEDIATED SIGNALLING 37 5.90e-01 -5.12e-02 0.837000
HEDGEHOG OFF STATE 107 3.61e-01 5.11e-02 0.695000
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 4.87e-01 5.11e-02 0.782000
SNRNP ASSEMBLY 51 5.30e-01 -5.09e-02 0.807000
DOWNREGULATION OF ERBB2 SIGNALING 27 6.48e-01 5.08e-02 0.871000
CELL JUNCTION ORGANIZATION 75 4.52e-01 5.03e-02 0.758000
DCC MEDIATED ATTRACTIVE SIGNALING 14 7.46e-01 5.00e-02 0.903000
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 4.33e-01 -4.96e-02 0.743000
INTERLEUKIN 1 FAMILY SIGNALING 122 3.45e-01 -4.95e-02 0.677000
DEUBIQUITINATION 243 1.88e-01 -4.91e-02 0.495000
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 7.42e-01 -4.90e-02 0.903000
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 2.51e-01 4.90e-02 0.575000
SIGNAL TRANSDUCTION BY L1 21 6.98e-01 4.90e-02 0.891000
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 6.66e-01 -4.89e-02 0.881000
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 7.06e-01 4.88e-02 0.895000
SIGNALING BY NTRK2 TRKB 24 6.79e-01 -4.87e-02 0.882000
SIGNALING BY RETINOIC ACID 34 6.25e-01 -4.84e-02 0.857000
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 77 4.65e-01 -4.82e-02 0.769000
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 25 6.77e-01 -4.81e-02 0.881000
BETA CATENIN INDEPENDENT WNT SIGNALING 139 3.28e-01 -4.81e-02 0.667000
SIGNALING BY RECEPTOR TYROSINE KINASES 459 8.07e-02 4.77e-02 0.335000
GPVI MEDIATED ACTIVATION CASCADE 31 6.46e-01 4.77e-02 0.870000
CHAPERONE MEDIATED AUTOPHAGY 19 7.21e-01 -4.73e-02 0.896000
HDR THROUGH MMEJ ALT NHEJ 10 7.96e-01 -4.72e-02 0.929000
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 6.02e-01 4.71e-02 0.838000
GLYCOGEN METABOLISM 25 6.85e-01 -4.70e-02 0.884000
TRANSCRIPTIONAL REGULATION BY RUNX1 179 2.79e-01 4.69e-02 0.613000
CA DEPENDENT EVENTS 36 6.27e-01 4.68e-02 0.857000
HEMOSTASIS 474 8.33e-02 4.66e-02 0.339000
CLATHRIN MEDIATED ENDOCYTOSIS 130 3.60e-01 4.66e-02 0.695000
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 4.95e-01 -4.65e-02 0.784000
SUMOYLATION OF DNA REPLICATION PROTEINS 43 5.98e-01 -4.64e-02 0.838000
HYALURONAN UPTAKE AND DEGRADATION 11 7.90e-01 4.64e-02 0.929000
EXTENSION OF TELOMERES 49 5.77e-01 -4.61e-02 0.832000
HIV TRANSCRIPTION ELONGATION 42 6.05e-01 4.61e-02 0.841000
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 6.80e-01 4.59e-02 0.882000
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 7.66e-01 -4.59e-02 0.916000
SIGNALING BY INTERLEUKINS 348 1.44e-01 -4.56e-02 0.445000
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 7.18e-01 4.56e-02 0.896000
INSULIN RECEPTOR SIGNALLING CASCADE 42 6.10e-01 -4.56e-02 0.845000
TIGHT JUNCTION INTERACTIONS 20 7.26e-01 4.52e-02 0.896000
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 6.44e-01 4.52e-02 0.870000
NERVOUS SYSTEM DEVELOPMENT 547 7.17e-02 4.52e-02 0.311000
INTERLEUKIN 27 SIGNALING 10 8.05e-01 4.50e-02 0.935000
SIGNALING BY MET 75 5.01e-01 4.50e-02 0.786000
RHO GTPASES ACTIVATE ROCKS 19 7.35e-01 4.49e-02 0.900000
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 6.69e-01 -4.44e-02 0.881000
NUCLEAR SIGNALING BY ERBB4 30 6.74e-01 4.44e-02 0.881000
SUMOYLATION OF SUMOYLATION PROTEINS 33 6.61e-01 -4.42e-02 0.880000
RHO GTPASES ACTIVATE PKNS 47 6.01e-01 -4.41e-02 0.838000
EPHB MEDIATED FORWARD SIGNALING 42 6.22e-01 4.40e-02 0.855000
AQUAPORIN MEDIATED TRANSPORT 40 6.33e-01 -4.37e-02 0.860000
LEISHMANIA INFECTION 189 3.03e-01 4.35e-02 0.645000
SUPPRESSION OF PHAGOSOMAL MATURATION 12 7.95e-01 -4.32e-02 0.929000
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 7.81e-01 4.29e-02 0.928000
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 6.54e-01 -4.27e-02 0.874000
SIGNALING BY VEGF 101 4.60e-01 4.26e-02 0.765000
NUCLEOBASE BIOSYNTHESIS 15 7.75e-01 4.26e-02 0.924000
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 7.08e-01 -4.24e-02 0.895000
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 6.55e-01 -4.20e-02 0.874000
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 7.59e-01 -4.18e-02 0.911000
SIGNALING BY EGFR IN CANCER 21 7.40e-01 -4.18e-02 0.902000
RHOG GTPASE CYCLE 73 5.42e-01 4.13e-02 0.811000
FCGR3A MEDIATED IL10 SYNTHESIS 32 6.86e-01 4.13e-02 0.884000
COMPLEMENT CASCADE 24 7.31e-01 -4.05e-02 0.900000
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 43 6.46e-01 -4.05e-02 0.870000
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 63 5.80e-01 -4.03e-02 0.832000
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 5.68e-01 -4.01e-02 0.827000
DUAL INCISION IN TC NER 65 5.77e-01 -4.00e-02 0.832000
ACYL CHAIN REMODELLING OF PC 17 7.76e-01 3.99e-02 0.924000
SIGNALLING TO ERKS 32 6.99e-01 3.95e-02 0.891000
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 7.14e-01 -3.94e-02 0.896000
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 7.49e-01 3.93e-02 0.905000
INNATE IMMUNE SYSTEM 773 6.47e-02 -3.93e-02 0.303000
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 7.20e-01 -3.92e-02 0.896000
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 7.41e-01 -3.90e-02 0.902000
NICOTINAMIDE SALVAGING 15 7.97e-01 -3.84e-02 0.929000
PLATELET SENSITIZATION BY LDL 15 7.99e-01 -3.80e-02 0.930000
HSF1 ACTIVATION 27 7.33e-01 3.79e-02 0.900000
ESR MEDIATED SIGNALING 163 4.07e-01 -3.77e-02 0.720000
GPCR LIGAND BINDING 247 3.09e-01 3.76e-02 0.649000
PHASE I FUNCTIONALIZATION OF COMPOUNDS 58 6.22e-01 3.74e-02 0.855000
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 8.38e-01 -3.73e-02 0.949000
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 8.38e-01 -3.73e-02 0.949000
SUMOYLATION OF RNA BINDING PROTEINS 45 6.66e-01 -3.72e-02 0.881000
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 8.18e-01 3.68e-02 0.945000
INFECTIOUS DISEASE 722 9.62e-02 -3.65e-02 0.366000
TRANSPORT OF SMALL MOLECULES 569 1.39e-01 3.65e-02 0.437000
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 6.62e-01 3.64e-02 0.881000
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 6.66e-01 3.64e-02 0.881000
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 7.39e-01 3.64e-02 0.902000
G PROTEIN MEDIATED EVENTS 52 6.52e-01 3.62e-02 0.872000
NUCLEAR ENVELOPE NE REASSEMBLY 64 6.22e-01 3.57e-02 0.855000
NOD1 2 SIGNALING PATHWAY 34 7.19e-01 3.56e-02 0.896000
RHO GTPASES ACTIVATE WASPS AND WAVES 36 7.14e-01 -3.53e-02 0.896000
NEGATIVE REGULATION OF FGFR1 SIGNALING 25 7.60e-01 3.53e-02 0.911000
RHOQ GTPASE CYCLE 57 6.46e-01 3.51e-02 0.870000
RECEPTOR MEDIATED MITOPHAGY 11 8.40e-01 -3.51e-02 0.949000
VXPX CARGO TARGETING TO CILIUM 19 7.92e-01 -3.50e-02 0.929000
TRANSCRIPTIONAL REGULATION BY RUNX3 92 5.68e-01 -3.45e-02 0.827000
METABOLISM OF STEROIDS 112 5.30e-01 -3.43e-02 0.807000
CELLULAR RESPONSES TO EXTERNAL STIMULI 600 1.55e-01 -3.41e-02 0.462000
RHO GTPASES ACTIVATE FORMINS 118 5.26e-01 -3.39e-02 0.805000
CELL CELL JUNCTION ORGANIZATION 51 6.76e-01 -3.38e-02 0.881000
FORMATION OF TC NER PRE INCISION COMPLEX 53 6.71e-01 -3.38e-02 0.881000
ARACHIDONIC ACID METABOLISM 39 7.17e-01 3.36e-02 0.896000
RHO GTPASES ACTIVATE PAKS 21 7.90e-01 -3.36e-02 0.929000
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 8.25e-01 -3.30e-02 0.946000
GENE SILENCING BY RNA 83 6.10e-01 3.24e-02 0.845000
VESICLE MEDIATED TRANSPORT 605 1.76e-01 3.23e-02 0.480000
METABOLISM OF STEROID HORMONES 20 8.03e-01 -3.22e-02 0.933000
FATTY ACID METABOLISM 145 5.04e-01 -3.22e-02 0.786000
SIGNALING BY WNT IN CANCER 30 7.61e-01 3.21e-02 0.912000
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 8.42e-01 3.19e-02 0.949000
SURFACTANT METABOLISM 17 8.21e-01 3.17e-02 0.946000
G ALPHA Z SIGNALLING EVENTS 45 7.14e-01 -3.16e-02 0.896000
DISEASES OF IMMUNE SYSTEM 24 7.89e-01 3.16e-02 0.929000
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 6.88e-01 3.16e-02 0.885000
METABOLISM OF LIPIDS 610 1.86e-01 3.15e-02 0.492000
NICOTINATE METABOLISM 24 7.91e-01 3.13e-02 0.929000
BASIGIN INTERACTIONS 23 7.97e-01 3.10e-02 0.929000
TRANSMISSION ACROSS CHEMICAL SYNAPSES 238 4.13e-01 3.09e-02 0.726000
MEMBRANE TRAFFICKING 576 2.14e-01 3.04e-02 0.526000
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 85 6.30e-01 3.03e-02 0.859000
FGFR2 ALTERNATIVE SPLICING 25 7.95e-01 3.01e-02 0.929000
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 6.12e-01 3.00e-02 0.845000
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 8.63e-01 -3.00e-02 0.958000
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 6.93e-01 2.93e-02 0.889000
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 41 7.46e-01 -2.92e-02 0.903000
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 8.58e-01 -2.87e-02 0.956000
MRNA CAPPING 29 7.90e-01 -2.86e-02 0.929000
REGULATION OF KIT SIGNALING 16 8.46e-01 -2.81e-02 0.950000
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.61e-01 -2.81e-02 0.957000
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 6.50e-01 -2.80e-02 0.872000
CARGO CONCENTRATION IN THE ER 30 7.91e-01 2.79e-02 0.929000
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 12 8.69e-01 2.76e-02 0.962000
RNA POLYMERASE I PROMOTER ESCAPE 47 7.45e-01 -2.74e-02 0.903000
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 8.54e-01 2.74e-02 0.954000
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 8.25e-01 -2.73e-02 0.946000
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 4.85e-01 2.72e-02 0.782000
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 6.83e-01 2.71e-02 0.884000
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 8.11e-01 2.71e-02 0.939000
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 8.16e-01 -2.69e-02 0.945000
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 7.60e-01 2.66e-02 0.911000
RNA POLYMERASE III CHAIN ELONGATION 18 8.46e-01 -2.64e-02 0.950000
HOMOLOGY DIRECTED REPAIR 108 6.37e-01 -2.63e-02 0.864000
RNA POLYMERASE I TRANSCRIPTION 67 7.12e-01 2.61e-02 0.896000
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 7.57e-01 2.60e-02 0.911000
BASE EXCISION REPAIR 57 7.35e-01 2.59e-02 0.900000
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 8.73e-01 -2.56e-02 0.963000
TOLL LIKE RECEPTOR CASCADES 138 6.06e-01 -2.54e-02 0.841000
REGULATION OF TP53 EXPRESSION AND DEGRADATION 35 7.95e-01 -2.54e-02 0.929000
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 8.48e-01 2.47e-02 0.950000
REGULATION OF SIGNALING BY CBL 22 8.42e-01 -2.46e-02 0.949000
TRANSCRIPTIONAL REGULATION BY TP53 342 4.36e-01 -2.46e-02 0.744000
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 7.07e-01 -2.45e-02 0.895000
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 8.26e-01 -2.45e-02 0.946000
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 7.82e-01 2.44e-02 0.928000
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 8.85e-01 2.41e-02 0.965000
BASE EXCISION REPAIR AP SITE FORMATION 29 8.24e-01 2.38e-02 0.946000
SIGNALING BY WNT 268 5.05e-01 -2.37e-02 0.786000
CLASS A 1 RHODOPSIN LIKE RECEPTORS 166 6.01e-01 2.36e-02 0.838000
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 8.66e-01 2.36e-02 0.961000
STRIATED MUSCLE CONTRACTION 28 8.30e-01 2.34e-02 0.946000
SARS COV 1 INFECTION 48 7.79e-01 -2.34e-02 0.928000
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 8.37e-01 2.34e-02 0.949000
RND1 GTPASE CYCLE 37 8.10e-01 -2.28e-02 0.939000
RAF ACTIVATION 34 8.18e-01 -2.28e-02 0.945000
POLO LIKE KINASE MEDIATED EVENTS 14 8.84e-01 -2.26e-02 0.965000
BIOLOGICAL OXIDATIONS 122 6.67e-01 -2.26e-02 0.881000
REGULATION OF INSULIN SECRETION 71 7.44e-01 2.24e-02 0.903000
SCAVENGING BY CLASS A RECEPTORS 13 8.89e-01 2.23e-02 0.967000
SIGNALING BY NUCLEAR RECEPTORS 221 5.71e-01 -2.22e-02 0.829000
RAC2 GTPASE CYCLE 86 7.23e-01 -2.21e-02 0.896000
UCH PROTEINASES 90 7.18e-01 -2.20e-02 0.896000
DOWNSTREAM SIGNAL TRANSDUCTION 29 8.38e-01 2.19e-02 0.949000
EPIGENETIC REGULATION OF GENE EXPRESSION 103 7.02e-01 2.18e-02 0.893000
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 92 7.18e-01 2.18e-02 0.896000
INTERLEUKIN 17 SIGNALING 66 7.62e-01 2.15e-02 0.912000
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 8.44e-01 -2.15e-02 0.950000
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 280 5.46e-01 2.10e-02 0.811000
SARS COV 2 INFECTION 65 7.70e-01 -2.10e-02 0.919000
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 8.23e-01 -2.09e-02 0.946000
CD28 DEPENDENT PI3K AKT SIGNALING 20 8.72e-01 2.09e-02 0.963000
RA BIOSYNTHESIS PATHWAY 14 8.93e-01 -2.08e-02 0.970000
DEFECTS IN COBALAMIN B12 METABOLISM 12 9.02e-01 -2.06e-02 0.974000
FERTILIZATION 12 9.02e-01 -2.04e-02 0.974000
SIGNALING BY FGFR4 32 8.41e-01 -2.04e-02 0.949000
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 7.45e-01 -2.04e-02 0.903000
SENSORY PERCEPTION 149 6.69e-01 2.03e-02 0.881000
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 30 8.48e-01 2.02e-02 0.950000
RAC3 GTPASE CYCLE 88 7.50e-01 -1.96e-02 0.905000
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 8.28e-01 1.96e-02 0.946000
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 8.37e-01 -1.95e-02 0.949000
SARS COV INFECTIONS 140 6.92e-01 1.94e-02 0.888000
MITOCHONDRIAL PROTEIN IMPORT 63 7.90e-01 -1.94e-02 0.929000
NEGATIVE REGULATION OF FGFR4 SIGNALING 22 8.77e-01 1.91e-02 0.965000
PTEN REGULATION 134 7.04e-01 -1.90e-02 0.895000
LYSOSOME VESICLE BIOGENESIS 32 8.53e-01 -1.89e-02 0.953000
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 8.71e-01 -1.88e-02 0.963000
G ALPHA Q SIGNALLING EVENTS 146 6.98e-01 -1.86e-02 0.891000
CIRCADIAN CLOCK 68 7.91e-01 1.86e-02 0.929000
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 8.34e-01 1.85e-02 0.949000
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.57e-01 1.84e-02 0.956000
SYNDECAN INTERACTIONS 26 8.72e-01 1.82e-02 0.963000
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 9.14e-01 -1.80e-02 0.977000
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 8.20e-01 -1.74e-02 0.946000
SEMA3A PAK DEPENDENT AXON REPULSION 16 9.06e-01 1.71e-02 0.976000
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 41 8.50e-01 1.70e-02 0.951000
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 8.89e-01 1.69e-02 0.967000
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 57 8.26e-01 1.69e-02 0.946000
BUDDING AND MATURATION OF HIV VIRION 27 8.80e-01 -1.67e-02 0.965000
TRAF6 MEDIATED IRF7 ACTIVATION 15 9.11e-01 -1.67e-02 0.977000
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 8.47e-01 1.66e-02 0.950000
PEPTIDE LIGAND BINDING RECEPTORS 96 7.80e-01 -1.65e-02 0.928000
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 8.02e-01 -1.65e-02 0.932000
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 9.12e-01 1.60e-02 0.977000
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 8.82e-01 -1.59e-02 0.965000
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 93 7.92e-01 1.59e-02 0.929000
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 90 7.95e-01 -1.59e-02 0.929000
RNA POLYMERASE III TRANSCRIPTION 41 8.61e-01 -1.58e-02 0.957000
PIWI INTERACTING RNA PIRNA BIOGENESIS 20 9.03e-01 -1.57e-02 0.974000
VISUAL PHOTOTRANSDUCTION 60 8.35e-01 1.56e-02 0.949000
PKA MEDIATED PHOSPHORYLATION OF CREB 19 9.07e-01 -1.55e-02 0.976000
GLUTATHIONE CONJUGATION 29 8.85e-01 -1.55e-02 0.965000
CYTOSOLIC TRNA AMINOACYLATION 24 8.96e-01 -1.54e-02 0.972000
FLT3 SIGNALING 37 8.72e-01 -1.53e-02 0.963000
EPHA MEDIATED GROWTH CONE COLLAPSE 29 8.87e-01 -1.52e-02 0.967000
NUCLEOTIDE EXCISION REPAIR 110 7.83e-01 -1.52e-02 0.928000
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 8.82e-01 -1.50e-02 0.965000
DNA REPAIR 292 6.62e-01 -1.49e-02 0.881000
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 19 9.11e-01 -1.49e-02 0.977000
UNWINDING OF DNA 12 9.30e-01 1.47e-02 0.988000
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 8.84e-01 -1.44e-02 0.965000
GROWTH HORMONE RECEPTOR SIGNALING 20 9.11e-01 1.44e-02 0.977000
SLC TRANSPORTER DISORDERS 74 8.30e-01 -1.44e-02 0.946000
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 364 6.40e-01 1.43e-02 0.867000
NUCLEAR ENVELOPE BREAKDOWN 49 8.63e-01 1.43e-02 0.958000
PRC2 METHYLATES HISTONES AND DNA 29 8.96e-01 -1.40e-02 0.972000
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 8.84e-01 -1.39e-02 0.965000
RHO GTPASE EFFECTORS 245 7.28e-01 1.29e-02 0.897000
MYD88 INDEPENDENT TLR4 CASCADE 94 8.30e-01 -1.28e-02 0.946000
BILE ACID AND BILE SALT METABOLISM 25 9.13e-01 1.27e-02 0.977000
NUCLEAR IMPORT OF REV PROTEIN 32 9.03e-01 -1.25e-02 0.974000
TRNA PROCESSING IN THE NUCLEUS 56 8.74e-01 -1.23e-02 0.963000
PROTEIN FOLDING 89 8.44e-01 1.21e-02 0.950000
REGULATION OF FZD BY UBIQUITINATION 19 9.29e-01 -1.19e-02 0.988000
CITRIC ACID CYCLE TCA CYCLE 22 9.29e-01 -1.10e-02 0.988000
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 9.51e-01 -1.08e-02 0.996000
POST TRANSLATIONAL PROTEIN MODIFICATION 1216 5.34e-01 -1.07e-02 0.810000
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 8.85e-01 -1.06e-02 0.965000
P75NTR REGULATES AXONOGENESIS 10 9.55e-01 1.03e-02 0.996000
AMINO ACIDS REGULATE MTORC1 51 9.01e-01 1.00e-02 0.974000
SIGNALING BY FGFR2 IIIA TM 19 9.41e-01 9.88e-03 0.995000
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 8.21e-01 -9.87e-03 0.946000
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 8.27e-01 9.46e-03 0.946000
ENDOGENOUS STEROLS 20 9.43e-01 -9.28e-03 0.995000
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 9.14e-01 -9.04e-03 0.977000
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.40e-01 9.01e-03 0.995000
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 9.52e-01 -8.94e-03 0.996000
INTERLEUKIN 15 SIGNALING 12 9.58e-01 8.69e-03 0.996000
HS GAG BIOSYNTHESIS 29 9.36e-01 -8.64e-03 0.993000
DUAL INCISION IN GG NER 41 9.27e-01 -8.29e-03 0.988000
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 9.66e-01 7.46e-03 0.996000
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.66e-01 -7.43e-03 0.996000
FGFR2 MUTANT RECEPTOR ACTIVATION 26 9.49e-01 -7.26e-03 0.996000
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 9.47e-01 7.26e-03 0.996000
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 9.69e-01 -7.12e-03 0.997000
REGULATION OF TP53 ACTIVITY 151 8.83e-01 6.97e-03 0.965000
SIALIC ACID METABOLISM 32 9.46e-01 -6.90e-03 0.996000
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 9.02e-01 -6.88e-03 0.974000
WNT LIGAND BIOGENESIS AND TRAFFICKING 23 9.55e-01 6.85e-03 0.996000
SIGNALING BY FGFR 72 9.23e-01 -6.61e-03 0.984000
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 9.63e-01 -6.39e-03 0.996000
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 9.22e-01 6.39e-03 0.984000
SIGNALING BY FGFR2 62 9.34e-01 -6.07e-03 0.992000
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 9.71e-01 6.06e-03 0.997000
SMOOTH MUSCLE CONTRACTION 33 9.52e-01 -6.05e-03 0.996000
TELOMERE EXTENSION BY TELOMERASE 22 9.61e-01 6.01e-03 0.996000
MEIOTIC SYNAPSIS 40 9.49e-01 -5.86e-03 0.996000
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 9.73e-01 5.69e-03 0.997000
DNA DOUBLE STRAND BREAK REPAIR 137 9.12e-01 -5.46e-03 0.977000
VITAMIN B5 PANTOTHENATE METABOLISM 14 9.74e-01 -5.07e-03 0.997000
SIGNALING BY FGFR3 35 9.59e-01 5.01e-03 0.996000
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 9.68e-01 -4.79e-03 0.997000
HEDGEHOG ON STATE 83 9.41e-01 4.69e-03 0.995000
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.79e-01 4.68e-03 0.997000
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 9.67e-01 4.65e-03 0.996000
GABA B RECEPTOR ACTIVATION 39 9.60e-01 -4.64e-03 0.996000
SPHINGOLIPID METABOLISM 81 9.43e-01 -4.63e-03 0.995000
MITOCHONDRIAL BIOGENESIS 92 9.40e-01 4.57e-03 0.995000
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 9.80e-01 -4.48e-03 0.997000
NEUROTRANSMITTER RELEASE CYCLE 47 9.58e-01 4.40e-03 0.996000
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 24 9.71e-01 4.32e-03 0.997000
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 9.74e-01 4.23e-03 0.997000
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 9.54e-01 -4.15e-03 0.996000
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 9.70e-01 4.09e-03 0.997000
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 9.61e-01 -3.89e-03 0.996000
AURKA ACTIVATION BY TPX2 71 9.56e-01 -3.80e-03 0.996000
FORMATION OF RNA POL II ELONGATION COMPLEX 57 9.64e-01 3.48e-03 0.996000
DNA DOUBLE STRAND BREAK RESPONSE 52 9.66e-01 3.44e-03 0.996000
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 92 9.56e-01 3.35e-03 0.996000
ESTROGEN DEPENDENT GENE EXPRESSION 102 9.62e-01 -2.72e-03 0.996000
CELLULAR RESPONSE TO HEAT STRESS 96 9.65e-01 2.57e-03 0.996000
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 29 9.82e-01 2.45e-03 0.997000
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 60 9.75e-01 -2.36e-03 0.997000
RESOLUTION OF ABASIC SITES AP SITES 38 9.82e-01 -2.13e-03 0.997000
ACYL CHAIN REMODELLING OF PE 16 9.91e-01 -1.65e-03 1.000000
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 9.88e-01 -1.58e-03 1.000000
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 90 9.80e-01 -1.56e-03 0.997000
TELOMERE MAINTENANCE 78 9.82e-01 -1.50e-03 0.997000
DISEASES OF PROGRAMMED CELL DEATH 54 9.86e-01 1.36e-03 1.000000
CILIUM ASSEMBLY 190 9.76e-01 -1.26e-03 0.997000
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 9.95e-01 1.25e-03 1.000000
G ALPHA I SIGNALLING EVENTS 192 9.81e-01 -9.94e-04 0.997000
MET RECEPTOR RECYCLING 10 9.96e-01 9.35e-04 1.000000
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 9.95e-01 8.98e-04 1.000000
PYRIMIDINE CATABOLISM 10 9.97e-01 7.93e-04 1.000000
ORGANELLE BIOGENESIS AND MAINTENANCE 282 9.85e-01 6.55e-04 0.999000
PCP CE PATHWAY 91 9.92e-01 6.02e-04 1.000000
MYOGENESIS 25 9.97e-01 4.50e-04 1.000000
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 9.96e-01 -3.88e-04 1.000000
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 9.98e-01 3.06e-04 1.000000
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 10 9.99e-01 2.84e-04 1.000000
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 9.99e-01 -2.37e-04 1.000000
RHOU GTPASE CYCLE 33 9.99e-01 1.62e-04 1.000000
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 9.99e-01 -1.36e-04 1.000000
TRANSCRIPTIONAL REGULATION BY MECP2 60 9.99e-01 -1.27e-04 1.000000
TRNA PROCESSING 105 1.00e+00 3.40e-06 1.000000


Detailed Gene set reports



COHESIN LOADING ONTO CHROMATIN
set COHESIN LOADING ONTO CHROMATIN
setSize 10
pANOVA 0.00353
s.dist -0.533
p.adjustANOVA 0.0607


Top enriched genes
Top 20 genes
GeneID Gene Rank
Smc3 -7975
Rad21 -7732
Stag2 -7578
Pds5b -6350
Wapl -5874
Nipbl -4860
Stag1 -4188
Pds5a -3295
Smc1a -3208
Mau2 8684

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Smc3 -7975
Rad21 -7732
Stag2 -7578
Pds5b -6350
Wapl -5874
Nipbl -4860
Stag1 -4188
Pds5a -3295
Smc1a -3208
Mau2 8684


SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
set SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize 12
pANOVA 0.0014
s.dist -0.533
p.adjustANOVA 0.0382


Top enriched genes
Top 20 genes
GeneID Gene Rank
Spcs2 -8035
Spcs3 -7897
Pcsk1 -7282
Dpp4 -7098
Spcs1 -5610
Sec11a -3721
Sec11c -3702
Tcf7l2 -2897
Ctnnb1 -2306
Pax6 -1839
Grp -1326
Gng13 885

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8035
Spcs3 -7897
Pcsk1 -7282
Dpp4 -7098
Spcs1 -5610
Sec11a -3721
Sec11c -3702
Tcf7l2 -2897
Ctnnb1 -2306
Pax6 -1839
Grp -1326
Gng13 885


INCRETIN SYNTHESIS SECRETION AND INACTIVATION
set INCRETIN SYNTHESIS SECRETION AND INACTIVATION
setSize 13
pANOVA 0.00118
s.dist -0.52
p.adjustANOVA 0.037


Top enriched genes
Top 20 genes
GeneID Gene Rank
Spcs2 -8035
Spcs3 -7897
Pcsk1 -7282
Dpp4 -7098
Spcs1 -5610
Sec11a -3721
Sec11c -3702
Tcf7l2 -2897
Isl1 -2806
Ctnnb1 -2306
Pax6 -1839
Grp -1326
Gng13 885

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8035
Spcs3 -7897
Pcsk1 -7282
Dpp4 -7098
Spcs1 -5610
Sec11a -3721
Sec11c -3702
Tcf7l2 -2897
Isl1 -2806
Ctnnb1 -2306
Pax6 -1839
Grp -1326
Gng13 885


POST CHAPERONIN TUBULIN FOLDING PATHWAY
set POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize 17
pANOVA 0.000264
s.dist 0.511
p.adjustANOVA 0.0173


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4a 8426
Tbcd 8185
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Arl2 6825
Tubb6 6799
Tuba1b 6071
Tubb2b 5527
Tuba4a 4513
Tuba1a 4382
Tbcb 3339
Tbcc 1422
Tuba8 1029
Tbce -2729
Tbca -6638

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 8426
Tbcd 8185
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Arl2 6825
Tubb6 6799
Tuba1b 6071
Tubb2b 5527
Tuba4a 4513
Tuba1a 4382
Tbcb 3339
Tbcc 1422
Tuba8 1029
Tbce -2729
Tbca -6638


CROSSLINKING OF COLLAGEN FIBRILS
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 15
pANOVA 0.000933
s.dist 0.494
p.adjustANOVA 0.0369


Top enriched genes
Top 20 genes
GeneID Gene Rank
Loxl1 8320
Loxl3 7720
Pxdn 7403
Pcolce 7373
Col4a2 6246
Col1a1 6221
Col4a1 5630
Bmp1 5234
Tll2 4748
Col4a5 4246
Col4a3 3819
Col1a2 2485
Col4a4 2369
Tll1 -2488
Loxl2 -2803

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Loxl1 8320
Loxl3 7720
Pxdn 7403
Pcolce 7373
Col4a2 6246
Col1a1 6221
Col4a1 5630
Bmp1 5234
Tll2 4748
Col4a5 4246
Col4a3 3819
Col1a2 2485
Col4a4 2369
Tll1 -2488
Loxl2 -2803


TERMINATION OF O GLYCAN BIOSYNTHESIS
set TERMINATION OF O GLYCAN BIOSYNTHESIS
setSize 11
pANOVA 0.00519
s.dist 0.487
p.adjustANOVA 0.0775


Top enriched genes
Top 20 genes
GeneID Gene Rank
St3gal3 8670
St6galnac4 7922
St3gal2 7112
St6galnac2 5746
St3gal1 4070
Muc6 4058
Muc3a 3710
St6galnac3 3383
Muc1 3354
St3gal4 2156
St6gal1 -2027

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
St3gal3 8670
St6galnac4 7922
St3gal2 7112
St6galnac2 5746
St3gal1 4070
Muc6 4058
Muc3a 3710
St6galnac3 3383
Muc1 3354
St3gal4 2156
St6gal1 -2027


PROCESSING AND ACTIVATION OF SUMO
set PROCESSING AND ACTIVATION OF SUMO
setSize 10
pANOVA 0.00821
s.dist -0.483
p.adjustANOVA 0.101


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sumo1 -7722
Sumo2 -7625
Rwdd3 -6509
Ube2i -5461
Senp5 -4327
Senp2 -3571
Uba2 -3147
Sumo3 -1651
Sae1 -1013
Senp1 2880

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sumo1 -7722
Sumo2 -7625
Rwdd3 -6509
Ube2i -5461
Senp5 -4327
Senp2 -3571
Uba2 -3147
Sumo3 -1651
Sae1 -1013
Senp1 2880


APOPTOSIS INDUCED DNA FRAGMENTATION
set APOPTOSIS INDUCED DNA FRAGMENTATION
setSize 10
pANOVA 0.00822
s.dist -0.483
p.adjustANOVA 0.101


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hmgb1 -8015
H1f2 -7876
Kpna1 -7627
H1f0 -7433
Casp3 -7248
H1f4 -5953
Hmgb2 -5383
Kpnb1 -1863
Dffb 6073
Dffa 7188

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hmgb1 -8015
H1f2 -7876
Kpna1 -7627
H1f0 -7433
Casp3 -7248
H1f4 -5953
Hmgb2 -5383
Kpnb1 -1863
Dffb 6073
Dffa 7188


ADENYLATE CYCLASE ACTIVATING PATHWAY
set ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize 10
pANOVA 0.0106
s.dist 0.467
p.adjustANOVA 0.11


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adcy6 7920
Adcy4 7519
Adcy5 7267
Adcy1 6295
Adcy3 6232
Adcy9 3794
Gnal 2366
Adcy2 1762
Adcy7 502
Adcy8 -1561

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 7920
Adcy4 7519
Adcy5 7267
Adcy1 6295
Adcy3 6232
Adcy9 3794
Gnal 2366
Adcy2 1762
Adcy7 502
Adcy8 -1561


TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
set TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize 13
pANOVA 0.0044
s.dist 0.456
p.adjustANOVA 0.0686


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4a 8426
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Tubb6 6799
Tuba1b 6071
Tubb2b 5527
Tuba4a 4513
Tuba1a 4382
Tuba8 1029
Gja1 -6683
Gjb2 -7259

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 8426
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Tubb6 6799
Tuba1b 6071
Tubb2b 5527
Tuba4a 4513
Tuba1a 4382
Tuba8 1029
Gja1 -6683
Gjb2 -7259


SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
set SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
setSize 12
pANOVA 0.00628
s.dist -0.456
p.adjustANOVA 0.0864


Top enriched genes
Top 20 genes
GeneID Gene Rank
Spcs2 -8035
Spcs3 -7897
Pla2g7 -7317
Pcsk1 -7282
Igf1 -6927
Bche -6193
Spcs1 -5610
Sec11a -3721
Sec11c -3702
Klf4 3051
Crhr2 3264
Ache 7349

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8035
Spcs3 -7897
Pla2g7 -7317
Pcsk1 -7282
Igf1 -6927
Bche -6193
Spcs1 -5610
Sec11a -3721
Sec11c -3702
Klf4 3051
Crhr2 3264
Ache 7349


CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
set CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
setSize 13
pANOVA 0.00532
s.dist 0.446
p.adjustANOVA 0.0778


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ercc2 8672
Nubp1 7765
Mms19 7730
Ciao3 7626
Ndor1 6393
Pold1 6078
Rtel1 5378
Nubp2 5000
Ciapin1 4424
Ciao2b 3944
Ciao1 1955
Brip1 -4789
Abcb7 -7699

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ercc2 8672
Nubp1 7765
Mms19 7730
Ciao3 7626
Ndor1 6393
Pold1 6078
Rtel1 5378
Nubp2 5000
Ciapin1 4424
Ciao2b 3944
Ciao1 1955
Brip1 -4789
Abcb7 -7699


CD28 DEPENDENT VAV1 PATHWAY
set CD28 DEPENDENT VAV1 PATHWAY
setSize 11
pANOVA 0.0114
s.dist -0.441
p.adjustANOVA 0.113


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdc42 -8103
Pak3 -7922
Pak2 -6950
Pak1 -6894
Rac1 -4972
Cd86 -3469
Cd80 -2957
Grb2 -1158
Fyn 1077
Lck 1386
Vav1 1922

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc42 -8103
Pak3 -7922
Pak2 -6950
Pak1 -6894
Rac1 -4972
Cd86 -3469
Cd80 -2957
Grb2 -1158
Fyn 1077
Lck 1386
Vav1 1922


ACTIVATION OF SMO
set ACTIVATION OF SMO
setSize 16
pANOVA 0.00279
s.dist 0.432
p.adjustANOVA 0.0553


Top enriched genes
Top 20 genes
GeneID Gene Rank
Arrb2 8418
Evc2 8192
Smo 7827
Grk2 7680
Evc 7388
Gas8 7026
Iqce 6950
Boc 6794
Gas1 6499
Arrb1 4564
Cdon 2828
Ptch1 1788
Shh -84
Kif3a -1377
Efcab7 -5254
Csnk1a1 -6642

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Arrb2 8418
Evc2 8192
Smo 7827
Grk2 7680
Evc 7388
Gas8 7026
Iqce 6950
Boc 6794
Gas1 6499
Arrb1 4564
Cdon 2828
Ptch1 1788
Shh -84
Kif3a -1377
Efcab7 -5254
Csnk1a1 -6642


MITOTIC TELOPHASE CYTOKINESIS
set MITOTIC TELOPHASE CYTOKINESIS
setSize 13
pANOVA 0.0112
s.dist -0.406
p.adjustANOVA 0.112


Top enriched genes
Top 20 genes
GeneID Gene Rank
Smc3 -7975
Rad21 -7732
Stag2 -7578
Pds5b -6350
Wapl -5874
Nipbl -4860
Stag1 -4188
Pds5a -3295
Smc1a -3208
Plk1 -585
Kif23 -565
Kif20a 2340
Mau2 8684

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Smc3 -7975
Rad21 -7732
Stag2 -7578
Pds5b -6350
Wapl -5874
Nipbl -4860
Stag1 -4188
Pds5a -3295
Smc1a -3208
Plk1 -585
Kif23 -565
Kif20a 2340
Mau2 8684


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 0.000173
s.dist -0.403
p.adjustANOVA 0.0145


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ube2k -8033
Ube2e1 -7991
Ube2w -7969
Ube2q2 -7843
Ube2d1 -7768
Ube2b -7711
Ube2g1 -7702
Ube2e3 -7467
Ube2l3 -7448
Usp9x -7192
Ube2a -7023
Ube2d2a -7012
Uba6 -6192
Uchl3 -5136
Ube2r2 -4377
Rps27a -4181
Otulin -3314
Usp7 -3159
Ube2h -3005
Ube2t -2664

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2k -8033
Ube2e1 -7991
Ube2w -7969
Ube2q2 -7843
Ube2d1 -7768
Ube2b -7711
Ube2g1 -7702
Ube2e3 -7467
Ube2l3 -7448
Usp9x -7192
Ube2a -7023
Ube2d2a -7012
Uba6 -6192
Uchl3 -5136
Ube2r2 -4377
Rps27a -4181
Otulin -3314
Usp7 -3159
Ube2h -3005
Ube2t -2664
Ube2s 515
Uba52 1260
Ube2z 2332
Cdc34 2971
Uba1 3200
Usp5 4890
Ubc 5007
Ubb 5657
Ube2g2 6410


MET ACTIVATES RAP1 AND RAC1
set MET ACTIVATES RAP1 AND RAC1
setSize 11
pANOVA 0.0226
s.dist -0.397
p.adjustANOVA 0.165


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rap1a -8158
Rap1b -7891
Hgf -5701
Met -5188
Crk -5174
Rac1 -4972
Crkl -4467
Dock7 -2597
Grb2 -1158
Gab1 3022
Rapgef1 8298

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rap1a -8158
Rap1b -7891
Hgf -5701
Met -5188
Crk -5174
Rac1 -4972
Crkl -4467
Dock7 -2597
Grb2 -1158
Gab1 3022
Rapgef1 8298


REPRESSION OF WNT TARGET GENES
set REPRESSION OF WNT TARGET GENES
setSize 14
pANOVA 0.0116
s.dist 0.389
p.adjustANOVA 0.113


Top enriched genes
Top 20 genes
GeneID Gene Rank
Axin2 7395
Tle1 7273
Ctbp2 6856
Tle2 6488
Ctbp1 6360
Myc 5788
Tle5 5581
Tcf7l1 5116
Tle3 4841
Hdac1 1596
Tcf7 -222
Lef1 -1908
Tle4 -2492
Tcf7l2 -2897

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Axin2 7395
Tle1 7273
Ctbp2 6856
Tle2 6488
Ctbp1 6360
Myc 5788
Tle5 5581
Tcf7l1 5116
Tle3 4841
Hdac1 1596
Tcf7 -222
Lef1 -1908
Tle4 -2492
Tcf7l2 -2897


CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
set CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
setSize 11
pANOVA 0.0267
s.dist -0.386
p.adjustANOVA 0.181


Top enriched genes
Top 20 genes
GeneID Gene Rank
Calm1 -7821
Prkacb -7731
Creb1 -7579
Prkar1a -7406
Prkar2b -7028
Prkx -4931
Prkar2a -3056
Adcy8 -1561
Prkar1b 3394
Prkaca 4462
Adcy1 6295

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calm1 -7821
Prkacb -7731
Creb1 -7579
Prkar1a -7406
Prkar2b -7028
Prkx -4931
Prkar2a -3056
Adcy8 -1561
Prkar1b 3394
Prkaca 4462
Adcy1 6295


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 10
pANOVA 0.0352
s.dist -0.385
p.adjustANOVA 0.219


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ywhae -7749
Ywhab -7698
Ywhaz -7569
Ywhaq -7061
Chek2 -4909
Ywhah -2678
Chek1 -2107
Wee1 -1048
Ywhag 4978
Sfn 5995

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ywhae -7749
Ywhab -7698
Ywhaz -7569
Ywhaq -7061
Chek2 -4909
Ywhah -2678
Chek1 -2107
Wee1 -1048
Ywhag 4978
Sfn 5995


CELLULAR HEXOSE TRANSPORT
set CELLULAR HEXOSE TRANSPORT
setSize 11
pANOVA 0.0292
s.dist 0.38
p.adjustANOVA 0.193


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc2a6 8711
Slc2a8 8471
Slc2a1 6714
Slc50a1 6018
Slc2a10 3505
Slc45a3 2966
Mfsd4b1 2676
Slc2a4 1976
Slc2a9 178
Slc2a3 -970
Slc2a12 -2022

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc2a6 8711
Slc2a8 8471
Slc2a1 6714
Slc50a1 6018
Slc2a10 3505
Slc45a3 2966
Mfsd4b1 2676
Slc2a4 1976
Slc2a9 178
Slc2a3 -970
Slc2a12 -2022


ACTIVATION OF RAC1
set ACTIVATION OF RAC1
setSize 13
pANOVA 0.0181
s.dist -0.378
p.adjustANOVA 0.144


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pak3 -7922
Pak5 -7377
Pak2 -6950
Pak1 -6894
Nck1 -6621
Slit2 -5868
Sos2 -5570
Sos1 -5299
Rac1 -4972
Robo1 1089
Pak6 3643
Nck2 6163
Pak4 8451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pak3 -7922
Pak5 -7377
Pak2 -6950
Pak1 -6894
Nck1 -6621
Slit2 -5868
Sos2 -5570
Sos1 -5299
Rac1 -4972
Robo1 1089
Pak6 3643
Nck2 6163
Pak4 8451


ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
set ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
setSize 20
pANOVA 0.0043
s.dist 0.369
p.adjustANOVA 0.0686


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4a 8426
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Tubb6 6799
Mapt 6129
Tuba1b 6071
Tubb2b 5527
Camkk2 4771
Tuba4a 4513
Tuba1a 4382
Prkag1 3222
Prkab1 2681
Prkag2 2418
Prkab2 1961
Tuba8 1029
Prkaa2 -6373
Prkaa1 -6884
Calm1 -7821

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 8426
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Tubb6 6799
Mapt 6129
Tuba1b 6071
Tubb2b 5527
Camkk2 4771
Tuba4a 4513
Tuba1a 4382
Prkag1 3222
Prkab1 2681
Prkag2 2418
Prkab2 1961
Tuba8 1029
Prkaa2 -6373
Prkaa1 -6884
Calm1 -7821


SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
set SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
setSize 14
pANOVA 0.0181
s.dist 0.365
p.adjustANOVA 0.144


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tln1 8370
Plxna3 8126
Fes 7857
Pip5k1c 7503
Plxna1 7482
Plxna4 4652
Rras 4495
Nrp1 3830
Plxna2 2466
Farp2 1725
Fyn 1077
Rnd1 146
Rac1 -4972
Sema3a -5884

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tln1 8370
Plxna3 8126
Fes 7857
Pip5k1c 7503
Plxna1 7482
Plxna4 4652
Rras 4495
Nrp1 3830
Plxna2 2466
Farp2 1725
Fyn 1077
Rnd1 146
Rac1 -4972
Sema3a -5884


SYNAPTIC ADHESION LIKE MOLECULES
set SYNAPTIC ADHESION LIKE MOLECULES
setSize 21
pANOVA 0.00408
s.dist 0.362
p.adjustANOVA 0.0672


Top enriched genes
Top 20 genes
GeneID Gene Rank
Grin2c 8593
Ptprs 8558
Grin1 8455
Lrfn4 8315
Lrfn1 8215
Grin2d 8089
Ptprf 7608
Lrfn3 7515
Lrfn2 7296
Flot2 7226
Dlg4 6508
Flot1 4933
Gria1 3703
Dlg3 2903
Grin2b 1090
Grin2a 994
Ptprd -3425
Gria4 -6483
Rtn3 -6489
Gria3 -6674

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grin2c 8593
Ptprs 8558
Grin1 8455
Lrfn4 8315
Lrfn1 8215
Grin2d 8089
Ptprf 7608
Lrfn3 7515
Lrfn2 7296
Flot2 7226
Dlg4 6508
Flot1 4933
Gria1 3703
Dlg3 2903
Grin2b 1090
Grin2a 994
Ptprd -3425
Gria4 -6483
Rtn3 -6489
Gria3 -6674
Dlg1 -7157


ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS
set ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS
setSize 35
pANOVA 0.00028
s.dist 0.355
p.adjustANOVA 0.0173


Top enriched genes
Top 20 genes
GeneID Gene Rank
Grin2c 8593
Grin1 8455
Tubb4a 8426
Grin2d 8089
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Lin7b 7436
Camk2b 7341
Tuba1c 7306
Actn2 7150
Tubb6 6799
Dlg4 6508
Kif17 6127
Tuba1b 6071
Camk2a 6021
Tubb2b 5527
Apba1 4876
Tuba4a 4513
Tuba1a 4382

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grin2c 8593
Grin1 8455
Tubb4a 8426
Grin2d 8089
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Lin7b 7436
Camk2b 7341
Tuba1c 7306
Actn2 7150
Tubb6 6799
Dlg4 6508
Kif17 6127
Tuba1b 6071
Camk2a 6021
Tubb2b 5527
Apba1 4876
Tuba4a 4513
Tuba1a 4382
Nefl 3458
Dlg3 2903
Camk2g 1604
Grin2b 1090
Tuba8 1029
Grin2a 994
Nbea 511
Lrrc7 -100
Lin7a -1367
Dlg2 -1834
Grin3a -2174
Cask -6479
Dlg1 -7157
Camk2d -7445
Lin7c -8023


FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES
set FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES
setSize 15
pANOVA 0.0186
s.dist 0.351
p.adjustANOVA 0.146


Top enriched genes
Top 20 genes
GeneID Gene Rank
Crebbp 7901
Stk11 7368
Nfyc 7283
Ddit3 7125
Bcl6 6404
Foxo4 5876
Nfya 4397
Bbc3 3850
Ep300 3625
Foxo3 1752
Pink1 1707
Cited2 -209
Bcl2l11 -593
Foxo1 -731
Nfyb -7312

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crebbp 7901
Stk11 7368
Nfyc 7283
Ddit3 7125
Bcl6 6404
Foxo4 5876
Nfya 4397
Bbc3 3850
Ep300 3625
Foxo3 1752
Pink1 1707
Cited2 -209
Bcl2l11 -593
Foxo1 -731
Nfyb -7312


NRAGE SIGNALS DEATH THROUGH JNK
set NRAGE SIGNALS DEATH THROUGH JNK
setSize 55
pANOVA 8.21e-06
s.dist 0.348
p.adjustANOVA 0.00201


Top enriched genes
Top 20 genes
GeneID Gene Rank
Arhgef4 8390
Plekhg5 8270
Arhgef5 8153
Arhgef10 8079
Plekhg2 8070
Arhgef10l 7988
Prex1 7980
Arhgef18 7899
Arhgef17 7879
Fgd1 7828
Arhgef2 7579
Arhgef40 7507
Arhgef11 7386
Arhgef1 7385
Vav2 7353
Mcf2l 7332
Arhgef7 7303
Arhgef19 7281
Abr 7032
Obscn 7004

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Arhgef4 8390
Plekhg5 8270
Arhgef5 8153
Arhgef10 8079
Plekhg2 8070
Arhgef10l 7988
Prex1 7980
Arhgef18 7899
Arhgef17 7879
Fgd1 7828
Arhgef2 7579
Arhgef40 7507
Arhgef11 7386
Arhgef1 7385
Vav2 7353
Mcf2l 7332
Arhgef7 7303
Arhgef19 7281
Abr 7032
Obscn 7004
Bad 6798
Kalrn 6585
Akap13 5881
Fgd3 5768
Trio 5421
Itsn1 5046
Fgd2 4975
Ngf 4741
Rasgrf2 4406
Arhgef33 4149
Maged1 3610
Arhgef15 3372
Arhgef6 3355
Arhgef16 3108
Tiam1 2576
Arhgef12 2169
Vav1 1922
Ngef 1301
Aatf 824
Arhgef26 448
Arhgef37 378
Bcl2l11 -593
Tiam2 -864
Ngfr -1289
Gna13 -1944
Arhgef3 -2878
Arhgef9 -3543
Vav3 -3613
Net1 -3836
Rac1 -4972
Sos1 -5299
Sos2 -5570
Mcf2 -6038
Fgd4 -6756
Mapk8 -7604


SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
set SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize 20
pANOVA 0.00728
s.dist -0.347
p.adjustANOVA 0.0968


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acsl4 -8101
Acsl3 -8077
Elovl4 -7454
Hsd17b12 -7249
Hacd3 -7170
Elovl7 -7037
Elovl5 -6106
Acsl5 -5532
Elovl2 -5409
Hacd1 -5152
Hacd2 -3848
Hacd4 -3354
Acsl1 -2954
Acsl6 -2703
Elovl6 -948
Acsf3 489
Tecr 4243
Acsbg1 7137
Elovl1 7469
Slc27a3 8499

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acsl4 -8101
Acsl3 -8077
Elovl4 -7454
Hsd17b12 -7249
Hacd3 -7170
Elovl7 -7037
Elovl5 -6106
Acsl5 -5532
Elovl2 -5409
Hacd1 -5152
Hacd2 -3848
Hacd4 -3354
Acsl1 -2954
Acsl6 -2703
Elovl6 -948
Acsf3 489
Tecr 4243
Acsbg1 7137
Elovl1 7469
Slc27a3 8499


A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
set A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize 26
pANOVA 0.00231
s.dist 0.345
p.adjustANOVA 0.0497


Top enriched genes
Top 20 genes
GeneID Gene Rank
B3gat1 8151
Bcan 7926
Xylt2 7498
Hspg2 7488
Agrn 7426
B3galt6 7404
Gpc1 7374
Gpc4 7131
Cspg4 6490
B3gat3 6052
Ncan 5819
Sdc3 5765
Bgn 5438
Gpc2 4211
Sdc4 3498
B4galt7 3223
Gpc6 2501
Cspg5 1966
B3gat2 1194
Vcan 694

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3gat1 8151
Bcan 7926
Xylt2 7498
Hspg2 7488
Agrn 7426
B3galt6 7404
Gpc1 7374
Gpc4 7131
Cspg4 6490
B3gat3 6052
Ncan 5819
Sdc3 5765
Bgn 5438
Gpc2 4211
Sdc4 3498
B4galt7 3223
Gpc6 2501
Cspg5 1966
B3gat2 1194
Vcan 694
Sdc1 -1456
Gpc3 -2332
Xylt1 -2809
Gpc5 -4618
Dcn -5720
Sdc2 -7631


MATURATION OF NUCLEOPROTEIN
set MATURATION OF NUCLEOPROTEIN
setSize 10
pANOVA 0.0599
s.dist -0.344
p.adjustANOVA 0.29


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sumo1 -7722
Ube2i -5461
Gsk3b -5344
Parp14 -4902
Parp9 -4765
Parp10 -1988
Parp4 -1383
Parp16 649
Parp6 1820
Parp8 2707

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sumo1 -7722
Ube2i -5461
Gsk3b -5344
Parp14 -4902
Parp9 -4765
Parp10 -1988
Parp4 -1383
Parp16 649
Parp6 1820
Parp8 2707


EARLY PHASE OF HIV LIFE CYCLE
set EARLY PHASE OF HIV LIFE CYCLE
setSize 13
pANOVA 0.0338
s.dist -0.34
p.adjustANOVA 0.213


Top enriched genes
Top 20 genes
GeneID Gene Rank
Psip1 -7884
Kpna1 -7627
Xrcc5 -7483
Xrcc4 -6725
Lig4 -5847
Ccr5 -5697
Ppia -4905
Xrcc6 -2305
Fen1 -377
Banf1 1779
Cxcr4 2238
Lig1 4075
Hmga1 6850

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psip1 -7884
Kpna1 -7627
Xrcc5 -7483
Xrcc4 -6725
Lig4 -5847
Ccr5 -5697
Ppia -4905
Xrcc6 -2305
Fen1 -377
Banf1 1779
Cxcr4 2238
Lig1 4075
Hmga1 6850


SIGNALING BY FGFR4 IN DISEASE
set SIGNALING BY FGFR4 IN DISEASE
setSize 10
pANOVA 0.0656
s.dist -0.336
p.adjustANOVA 0.304


Top enriched genes
Top 20 genes
GeneID Gene Rank
Kras -8145
Nras -7418
Pik3ca -7223
Pik3r1 -6337
Frs2 -5382
Sos1 -5299
Grb2 -1158
Gab1 3022
Hras 4088
Plcg1 8091

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kras -8145
Nras -7418
Pik3ca -7223
Pik3r1 -6337
Frs2 -5382
Sos1 -5299
Grb2 -1158
Gab1 3022
Hras 4088
Plcg1 8091


PRE NOTCH PROCESSING IN GOLGI
set PRE NOTCH PROCESSING IN GOLGI
setSize 18
pANOVA 0.0138
s.dist 0.335
p.adjustANOVA 0.127


Top enriched genes
Top 20 genes
GeneID Gene Rank
St3gal3 8670
Lfng 8472
Furin 8438
Notch3 8326
Notch1 8207
Rfng 8035
Notch4 7815
Notch2 6964
B4galt1 6165
Atp2a3 4830
Atp2a1 4136
St3gal4 2156
Mfng 659
Sel1l -2325
Atp2a2 -3232
Tmed2 -6844
Rab6a -6965
St3gal6 -7784

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
St3gal3 8670
Lfng 8472
Furin 8438
Notch3 8326
Notch1 8207
Rfng 8035
Notch4 7815
Notch2 6964
B4galt1 6165
Atp2a3 4830
Atp2a1 4136
St3gal4 2156
Mfng 659
Sel1l -2325
Atp2a2 -3232
Tmed2 -6844
Rab6a -6965
St3gal6 -7784


SIGNALING BY FGFR3 FUSIONS IN CANCER
set SIGNALING BY FGFR3 FUSIONS IN CANCER
setSize 10
pANOVA 0.0699
s.dist -0.331
p.adjustANOVA 0.308


Top enriched genes
Top 20 genes
GeneID Gene Rank
Kras -8145
Nras -7418
Pik3ca -7223
Pik3r1 -6337
Frs2 -5382
Sos1 -5299
Grb2 -1158
Gab1 3022
Hras 4088
Fgfr3 8528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kras -8145
Nras -7418
Pik3ca -7223
Pik3r1 -6337
Frs2 -5382
Sos1 -5299
Grb2 -1158
Gab1 3022
Hras 4088
Fgfr3 8528


E2F MEDIATED REGULATION OF DNA REPLICATION
set E2F MEDIATED REGULATION OF DNA REPLICATION
setSize 19
pANOVA 0.0137
s.dist -0.327
p.adjustANOVA 0.127


Top enriched genes
Top 20 genes
GeneID Gene Rank
Orc2 -7527
Orc4 -7514
Rb1 -7078
Orc5 -7052
Ppp2cb -6718
Orc3 -6568
Ppp2ca -6104
Orc6 -6083
Prim2 -5681
Prim1 -3039
Ppp2r1b -2846
Tfdp2 -1914
Pola1 -1353
Mcm8 -1038
E2f1 1562
Tfdp1 3787
Ppp2r1a 4453
Pola2 5124
Ppp2r3d 8205

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Orc2 -7527
Orc4 -7514
Rb1 -7078
Orc5 -7052
Ppp2cb -6718
Orc3 -6568
Ppp2ca -6104
Orc6 -6083
Prim2 -5681
Prim1 -3039
Ppp2r1b -2846
Tfdp2 -1914
Pola1 -1353
Mcm8 -1038
E2f1 1562
Tfdp1 3787
Ppp2r1a 4453
Pola2 5124
Ppp2r3d 8205


COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
set COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
setSize 62
pANOVA 9.19e-06
s.dist 0.326
p.adjustANOVA 0.00201


Top enriched genes
Top 20 genes
GeneID Gene Rank
Plod3 8519
Serpinh1 8201
Plod1 7476
Pcolce 7373
Colgalt1 7241
P3h1 7215
Adamts14 7162
P3h3 7139
Col9a3 6405
Col4a2 6246
Col1a1 6221
P3h2 6191
P4ha2 6132
Col18a1 5924
Col26a1 5838
Col27a1 5753
Col4a1 5630
Col11a2 5367
Bmp1 5234
Col13a1 5068

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plod3 8519
Serpinh1 8201
Plod1 7476
Pcolce 7373
Colgalt1 7241
P3h1 7215
Adamts14 7162
P3h3 7139
Col9a3 6405
Col4a2 6246
Col1a1 6221
P3h2 6191
P4ha2 6132
Col18a1 5924
Col26a1 5838
Col27a1 5753
Col4a1 5630
Col11a2 5367
Bmp1 5234
Col13a1 5068
Tll2 4748
Ppib 4723
Col2a1 4671
Col4a5 4246
Col12a1 4241
Col8a2 4123
Crtap 4110
P4ha3 4013
Col4a3 3819
Col20a1 3744
Col16a1 3724
Col11a1 3190
Col6a3 3169
Col7a1 3001
Adamts3 2784
Col1a2 2485
Col4a4 2369
Col22a1 2245
Col15a1 2148
Col9a2 2104
Adamts2 2000
Col19a1 1942
Col6a5 1503
Col5a2 1387
Col5a3 1113
Col6a1 1100
Col8a1 964
Col5a1 430
Pcolce2 -94
Col6a2 -510
Col6a6 -571
P4hb -603
Col23a1 -928
P4ha1 -1044
Col24a1 -1375
Col9a1 -1543
Col25a1 -1603
Colgalt2 -1862
Col14a1 -1867
Tll1 -2488
Col3a1 -3832
Plod2 -5533


SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX
set SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX
setSize 12
pANOVA 0.0522
s.dist 0.324
p.adjustANOVA 0.278


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mapkapk2 6595
Cyp4f14 6038
Ltc4s 5964
Abcc1 5858
Ggt5 5054
Cyp4f15 3835
Alox5ap 3480
Alox5 1484
Ggt1 1439
Cyp4f16 1016
Ptgr1 -2291
Lta4h -2470

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapkapk2 6595
Cyp4f14 6038
Ltc4s 5964
Abcc1 5858
Ggt5 5054
Cyp4f15 3835
Alox5ap 3480
Alox5 1484
Ggt1 1439
Cyp4f16 1016
Ptgr1 -2291
Lta4h -2470


CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
set CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
setSize 35
pANOVA 0.000978
s.dist 0.322
p.adjustANOVA 0.0369


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tubb4a 8426
Tpgs1 7989
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Ttll11 7546
Tuba1c 7306
Ttll3 7134
Ttll12 6969
Tubb6 6799
Agbl5 6657
Tuba1b 6071
Ttll8 5683
Ttll5 5551
Ttll1 5550
Vash1 5531
Tubb2b 5527
Ttll4 5095
Tuba4a 4513
Ttll9 4388

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 8426
Tpgs1 7989
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Ttll11 7546
Tuba1c 7306
Ttll3 7134
Ttll12 6969
Tubb6 6799
Agbl5 6657
Tuba1b 6071
Ttll8 5683
Ttll5 5551
Ttll1 5550
Vash1 5531
Tubb2b 5527
Ttll4 5095
Tuba4a 4513
Ttll9 4388
Tuba1a 4382
Ttl 3397
Agbl2 1902
Ttll13 1857
Ttll6 1213
Tuba8 1029
Nicn1 -1703
Svbp -2543
Agtpbp1 -2943
Lrrc49 -3372
Agbl4 -4442
Vash2 -5031
Tpgs2 -5646
Agbl3 -6883
Ttll7 -7008


SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
set SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
setSize 23
pANOVA 0.00757
s.dist 0.322
p.adjustANOVA 0.0985


Top enriched genes
Top 20 genes
GeneID Gene Rank
Lemd2 8553
Tubb4a 8426
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Tubb6 6799
Tuba1b 6071
Cc2d1b 5972
Tubb2b 5527
Chmp4b 4930
Tuba4a 4513
Chmp6 4396
Tuba1a 4382
Chmp7 2984
Tuba8 1029
Chmp4c 76
Ist1 -208
Chmp2a -792
Vps4a -4073

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lemd2 8553
Tubb4a 8426
Tubb2a 7830
Tubb3 7811
Tubb4b 7800
Tuba1c 7306
Tubb6 6799
Tuba1b 6071
Cc2d1b 5972
Tubb2b 5527
Chmp4b 4930
Tuba4a 4513
Chmp6 4396
Tuba1a 4382
Chmp7 2984
Tuba8 1029
Chmp4c 76
Ist1 -208
Chmp2a -792
Vps4a -4073
Chmp3 -6147
Chmp2b -6780
Spast -7829


NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
set NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 20
pANOVA 0.013
s.dist 0.321
p.adjustANOVA 0.121


Top enriched genes
Top 20 genes
GeneID Gene Rank
Notch1 8207
Crebbp 7901
Notch4 7815
Notch2 6964
Kat2a 6305
Hes5 5451
Flt4 5340
Smad3 5299
Maml3 5073
Maml1 4946
Hes1 4488
Ep300 3625
Mamld1 2255
Maml2 1087
Acta2 926
Hey1 -426
Rbpj -1288
Hey2 -2062
Kat2b -5161
Snw1 -7227

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 8207
Crebbp 7901
Notch4 7815
Notch2 6964
Kat2a 6305
Hes5 5451
Flt4 5340
Smad3 5299
Maml3 5073
Maml1 4946
Hes1 4488
Ep300 3625
Mamld1 2255
Maml2 1087
Acta2 926
Hey1 -426
Rbpj -1288
Hey2 -2062
Kat2b -5161
Snw1 -7227


CRMPS IN SEMA3A SIGNALING
set CRMPS IN SEMA3A SIGNALING
setSize 16
pANOVA 0.0265
s.dist 0.32
p.adjustANOVA 0.181


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dpysl4 8304
Plxna3 8126
Fes 7857
Dpysl5 7683
Plxna1 7482
Crmp1 7172
Cdk5 6450
Plxna4 4652
Nrp1 3830
Plxna2 2466
Fyn 1077
Dpysl2 -162
Cdk5r1 -2887
Dpysl3 -3274
Gsk3b -5344
Sema3a -5884

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dpysl4 8304
Plxna3 8126
Fes 7857
Dpysl5 7683
Plxna1 7482
Crmp1 7172
Cdk5 6450
Plxna4 4652
Nrp1 3830
Plxna2 2466
Fyn 1077
Dpysl2 -162
Cdk5r1 -2887
Dpysl3 -3274
Gsk3b -5344
Sema3a -5884


ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
set ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize 19
pANOVA 0.0172
s.dist -0.316
p.adjustANOVA 0.143


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gng2 -7366
P2ry12 -7237
Gnai3 -6942
Gng12 -6677
Gnai1 -6666
Gnb4 -5924
Gng11 -5749
Gng10 -5647
Gnb1 -5214
Gng5 -4131
Gng4 -2591
Gng3 -1020
Gngt2 30
Gng8 857
Gng13 885
Gnb5 1614
Gng7 4538
Gnai2 4799
Gnb2 6809

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng2 -7366
P2ry12 -7237
Gnai3 -6942
Gng12 -6677
Gnai1 -6666
Gnb4 -5924
Gng11 -5749
Gng10 -5647
Gnb1 -5214
Gng5 -4131
Gng4 -2591
Gng3 -1020
Gngt2 30
Gng8 857
Gng13 885
Gnb5 1614
Gng7 4538
Gnai2 4799
Gnb2 6809


NCAM1 INTERACTIONS
set NCAM1 INTERACTIONS
setSize 40
pANOVA 0.000634
s.dist 0.312
p.adjustANOVA 0.031


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cacna1h 8637
Agrn 7426
Cacnb3 7342
Nrtn 7287
Cacna1i 6700
Cacnb1 6628
Col9a3 6405
Col4a2 6246
Cacna1d 6211
Cacna1g 5827
Ncan 5819
Cntn2 5815
Cacna1c 5648
Col4a1 5630
Gfra4 5467
Col2a1 4671
St8sia2 4419
Col4a5 4246
Col4a3 3819
Gfra1 3241

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cacna1h 8637
Agrn 7426
Cacnb3 7342
Nrtn 7287
Cacna1i 6700
Cacnb1 6628
Col9a3 6405
Col4a2 6246
Cacna1d 6211
Cacna1g 5827
Ncan 5819
Cntn2 5815
Cacna1c 5648
Col4a1 5630
Gfra4 5467
Col2a1 4671
St8sia2 4419
Col4a5 4246
Col4a3 3819
Gfra1 3241
Col6a3 3169
Ncam1 3083
Artn 2837
Col4a4 2369
Gfra2 2135
Col9a2 2104
Cacna1s 1912
Col6a5 1503
Col5a2 1387
Col5a3 1113
Col6a1 1100
Col5a1 430
Cacnb2 65
Col6a2 -510
Col6a6 -571
Col9a1 -1543
Prnp -3212
Col3a1 -3832
St8sia4 -7193
Cacnb4 -7878


PEXOPHAGY
set PEXOPHAGY
setSize 11
pANOVA 0.0801
s.dist 0.305
p.adjustANOVA 0.334


Top enriched genes
Top 20 genes
GeneID Gene Rank
Usp30 7416
Pex5 7019
Epas1 5778
Ubb 5657
Ubc 5007
Map1lc3b 4910
Sqstm1 1772
Uba52 1260
Atm -1121
Nbr1 -2277
Rps27a -4181

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Usp30 7416
Pex5 7019
Epas1 5778
Ubb 5657
Ubc 5007
Map1lc3b 4910
Sqstm1 1772
Uba52 1260
Atm -1121
Nbr1 -2277
Rps27a -4181


REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
set REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
setSize 13
pANOVA 0.0574
s.dist 0.304
p.adjustANOVA 0.287


Top enriched genes
Top 20 genes
GeneID Gene Rank
Banp 8274
Ppp1r13b 7982
Trp73 7474
Akt1 7006
Ppp1r13l 6782
Zfp385a 6525
Trp53 5414
Akt2 2312
Pou4f1 -1632
Akt3 -1940
Trp53bp2 -2941
Trp63 -3964
Phf20 -4409

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Banp 8274
Ppp1r13b 7982
Trp73 7474
Akt1 7006
Ppp1r13l 6782
Zfp385a 6525
Trp53 5414
Akt2 2312
Pou4f1 -1632
Akt3 -1940
Trp53bp2 -2941
Trp63 -3964
Phf20 -4409


INSULIN PROCESSING
set INSULIN PROCESSING
setSize 24
pANOVA 0.00989
s.dist -0.304
p.adjustANOVA 0.109


Top enriched genes
Top 20 genes
GeneID Gene Rank
Exoc5 -8010
Pcsk1 -7282
Exoc6 -7182
Kif5b -6791
Ero1a -6535
Exoc2 -6111
Kif5c -5855
Ero1b -5812
Slc30a5 -5549
Cpe -5246
Exoc3 -4704
Myo5a -3777
Slc30a7 -3660
Vamp2 -2509
Pcsk2 -1771
Exoc1 -1446
Slc30a6 346
Stx1a 2183
Exoc4 2220
Kif5a 2290

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Exoc5 -8010
Pcsk1 -7282
Exoc6 -7182
Kif5b -6791
Ero1a -6535
Exoc2 -6111
Kif5c -5855
Ero1b -5812
Slc30a5 -5549
Cpe -5246
Exoc3 -4704
Myo5a -3777
Slc30a7 -3660
Vamp2 -2509
Pcsk2 -1771
Exoc1 -1446
Slc30a6 346
Stx1a 2183
Exoc4 2220
Kif5a 2290
Exoc8 2446
Rab27a 3708
Myrip 6427
Exoc7 7335


PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
set PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
setSize 11
pANOVA 0.0821
s.dist 0.303
p.adjustANOVA 0.337


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cacna1a 7947
Cacnb3 7342
Cacng4 6643
Cacnb1 6628
Cacna1b 6422
Cacna2d2 2591
Cacna1e 1062
Cacng2 316
Cacnb2 65
Cacna2d3 -77
Cacnb4 -7878

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cacna1a 7947
Cacnb3 7342
Cacng4 6643
Cacnb1 6628
Cacna1b 6422
Cacna2d2 2591
Cacna1e 1062
Cacng2 316
Cacnb2 65
Cacna2d3 -77
Cacnb4 -7878


G BETA GAMMA SIGNALLING THROUGH CDC42
set G BETA GAMMA SIGNALLING THROUGH CDC42
setSize 18
pANOVA 0.0263
s.dist -0.303
p.adjustANOVA 0.181


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdc42 -8103
Gng2 -7366
Pak1 -6894
Gng12 -6677
Gnb4 -5924
Gng11 -5749
Gng10 -5647
Gnb1 -5214
Gng5 -4131
Gng4 -2591
Gng3 -1020
Gngt2 30
Gng8 857
Gng13 885
Gnb5 1614
Arhgef6 3355
Gng7 4538
Gnb2 6809

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc42 -8103
Gng2 -7366
Pak1 -6894
Gng12 -6677
Gnb4 -5924
Gng11 -5749
Gng10 -5647
Gnb1 -5214
Gng5 -4131
Gng4 -2591
Gng3 -1020
Gngt2 30
Gng8 857
Gng13 885
Gnb5 1614
Arhgef6 3355
Gng7 4538
Gnb2 6809


NF KB IS ACTIVATED AND SIGNALS SURVIVAL
set NF KB IS ACTIVATED AND SIGNALS SURVIVAL
setSize 13
pANOVA 0.059
s.dist 0.302
p.adjustANOVA 0.288


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ikbkb 7714
Rela 7696
Irak1 6190
Ubb 5657
Ubc 5007
Ngf 4741
Nfkb1 4062
Sqstm1 1772
Uba52 1260
Nfkbia -111
Ngfr -1289
Traf6 -1855
Rps27a -4181

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ikbkb 7714
Rela 7696
Irak1 6190
Ubb 5657
Ubc 5007
Ngf 4741
Nfkb1 4062
Sqstm1 1772
Uba52 1260
Nfkbia -111
Ngfr -1289
Traf6 -1855
Rps27a -4181


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report