date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik -2.2697336
0610009E02Rik -0.3519839
0610009L18Rik -0.9139963
0610010K14Rik -0.1751685
0610012G03Rik 0.5678859
0610030E20Rik 1.4359134

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16937
duplicated_genes_present 0
num_profile_genes_in_sets 8287
num_profile_genes_not_in_sets 8650

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 433
num_genesets_included 1171

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 8.70e-05 -0.654 9.58e-04
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 5.24e-05 -0.648 6.20e-04
EUKARYOTIC TRANSLATION ELONGATION 87 1.82e-20 -0.575 4.26e-18
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 8.83e-08 -0.555 2.53e-06
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.91e-13 -0.553 1.24e-11
EUKARYOTIC TRANSLATION INITIATION 114 3.54e-24 -0.550 2.07e-21
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 4.70e-22 -0.542 1.43e-19
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 2.26e-19 -0.537 3.78e-17
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 1.55e-03 -0.528 1.19e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.89e-03 0.514 3.01e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.39e-06 -0.498 5.83e-05
COMPLEX I BIOGENESIS 56 1.48e-10 -0.495 8.26e-09
CD28 DEPENDENT VAV1 PATHWAY 11 4.93e-03 -0.490 3.03e-02
CRMPS IN SEMA3A SIGNALING 16 7.16e-04 0.489 6.30e-03
SELENOAMINO ACID METABOLISM 109 2.80e-18 -0.483 3.64e-16
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.03e-03 -0.477 4.87e-02
PROTEIN METHYLATION 17 7.84e-04 -0.470 6.80e-03
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.39e-03 -0.459 4.63e-02
RESPIRATORY ELECTRON TRANSPORT 102 1.32e-15 -0.458 1.19e-13
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 1.25e-02 0.456 6.37e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 5.92e-04 -0.455 5.29e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.37e-02 0.450 6.81e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.77e-03 0.447 2.48e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.42e-03 0.447 1.11e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 1.20e-07 -0.446 3.26e-06
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.45e-08 -0.446 5.47e-07
NONSENSE MEDIATED DECAY NMD 109 8.89e-16 -0.446 9.36e-14
TRIGLYCERIDE CATABOLISM 14 4.24e-03 -0.441 2.74e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 4.88e-22 -0.441 1.43e-19
CRISTAE FORMATION 31 2.29e-05 -0.439 3.04e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.77e-17 -0.438 3.24e-15
NRAGE SIGNALS DEATH THROUGH JNK 55 2.06e-08 0.437 7.32e-07
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 6.54e-09 -0.437 2.84e-07
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 7.95e-09 -0.434 3.21e-07
SIGNALING BY LEPTIN 10 1.77e-02 0.433 8.29e-02
INTERLEUKIN 12 SIGNALING 37 5.32e-06 -0.432 8.58e-05
PROCESSING OF SMDT1 16 2.90e-03 -0.430 2.01e-02
GLYCOGEN SYNTHESIS 14 5.59e-03 -0.428 3.32e-02
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 7.11e-08 -0.424 2.19e-06
TRANSLATION 286 7.12e-35 -0.423 8.34e-32
MITOCHONDRIAL TRANSLATION 93 1.78e-12 -0.423 1.10e-10
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.90e-03 -0.423 1.40e-02
METABOLISM OF POLYAMINES 58 3.05e-08 -0.420 1.05e-06
SYNAPTIC ADHESION LIKE MOLECULES 21 8.80e-04 0.419 7.47e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.50e-04 -0.415 2.44e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.37e-02 -0.413 1.04e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.46e-03 -0.412 1.74e-02
ACTIVATION OF SMO 16 4.70e-03 0.408 2.94e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.98e-20 -0.407 5.82e-18
CROSSLINKING OF COLLAGEN FIBRILS 15 6.45e-03 0.406 3.67e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 8.70e-05 -0.654000 9.58e-04
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 5.24e-05 -0.648000 6.20e-04
EUKARYOTIC TRANSLATION ELONGATION 87 1.82e-20 -0.575000 4.26e-18
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 8.83e-08 -0.555000 2.53e-06
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.91e-13 -0.553000 1.24e-11
EUKARYOTIC TRANSLATION INITIATION 114 3.54e-24 -0.550000 2.07e-21
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 4.70e-22 -0.542000 1.43e-19
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 2.26e-19 -0.537000 3.78e-17
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 1.55e-03 -0.528000 1.19e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.89e-03 0.514000 3.01e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.39e-06 -0.498000 5.83e-05
COMPLEX I BIOGENESIS 56 1.48e-10 -0.495000 8.26e-09
CD28 DEPENDENT VAV1 PATHWAY 11 4.93e-03 -0.490000 3.03e-02
CRMPS IN SEMA3A SIGNALING 16 7.16e-04 0.489000 6.30e-03
SELENOAMINO ACID METABOLISM 109 2.80e-18 -0.483000 3.64e-16
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.03e-03 -0.477000 4.87e-02
PROTEIN METHYLATION 17 7.84e-04 -0.470000 6.80e-03
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.39e-03 -0.459000 4.63e-02
RESPIRATORY ELECTRON TRANSPORT 102 1.32e-15 -0.458000 1.19e-13
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 1.25e-02 0.456000 6.37e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 5.92e-04 -0.455000 5.29e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.37e-02 0.450000 6.81e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.77e-03 0.447000 2.48e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.42e-03 0.447000 1.11e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 1.20e-07 -0.446000 3.26e-06
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.45e-08 -0.446000 5.47e-07
NONSENSE MEDIATED DECAY NMD 109 8.89e-16 -0.446000 9.36e-14
TRIGLYCERIDE CATABOLISM 14 4.24e-03 -0.441000 2.74e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 4.88e-22 -0.441000 1.43e-19
CRISTAE FORMATION 31 2.29e-05 -0.439000 3.04e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.77e-17 -0.438000 3.24e-15
NRAGE SIGNALS DEATH THROUGH JNK 55 2.06e-08 0.437000 7.32e-07
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 6.54e-09 -0.437000 2.84e-07
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 7.95e-09 -0.434000 3.21e-07
SIGNALING BY LEPTIN 10 1.77e-02 0.433000 8.29e-02
INTERLEUKIN 12 SIGNALING 37 5.32e-06 -0.432000 8.58e-05
PROCESSING OF SMDT1 16 2.90e-03 -0.430000 2.01e-02
GLYCOGEN SYNTHESIS 14 5.59e-03 -0.428000 3.32e-02
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 7.11e-08 -0.424000 2.19e-06
TRANSLATION 286 7.12e-35 -0.423000 8.34e-32
MITOCHONDRIAL TRANSLATION 93 1.78e-12 -0.423000 1.10e-10
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.90e-03 -0.423000 1.40e-02
METABOLISM OF POLYAMINES 58 3.05e-08 -0.420000 1.05e-06
SYNAPTIC ADHESION LIKE MOLECULES 21 8.80e-04 0.419000 7.47e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.50e-04 -0.415000 2.44e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.37e-02 -0.413000 1.04e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.46e-03 -0.412000 1.74e-02
ACTIVATION OF SMO 16 4.70e-03 0.408000 2.94e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.98e-20 -0.407000 5.82e-18
CROSSLINKING OF COLLAGEN FIBRILS 15 6.45e-03 0.406000 3.67e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 2.16e-02 -0.400000 9.55e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 2.61e-04 0.399000 2.53e-03
INTERACTION BETWEEN L1 AND ANKYRINS 27 3.39e-04 0.398000 3.15e-03
RORA ACTIVATES GENE EXPRESSION 18 3.46e-03 0.398000 2.32e-02
STABILIZATION OF P53 55 3.33e-07 -0.398000 7.36e-06
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 6.04e-03 -0.396000 3.52e-02
TRANSLESION SYNTHESIS BY POLH 19 2.90e-03 -0.395000 2.01e-02
METHYLATION 11 2.50e-02 -0.390000 1.09e-01
PYRUVATE METABOLISM 27 4.59e-04 -0.390000 4.20e-03
INTERLEUKIN 37 SIGNALING 17 5.54e-03 0.389000 3.31e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 9.95e-07 -0.389000 1.94e-05
EARLY PHASE OF HIV LIFE CYCLE 13 1.54e-02 -0.388000 7.43e-02
NCAM1 INTERACTIONS 40 2.19e-05 0.388000 2.98e-04
TRANSLESION SYNTHESIS BY POLK 17 6.22e-03 -0.383000 3.61e-02
RUNX3 REGULATES NOTCH SIGNALING 13 1.76e-02 0.380000 8.29e-02
CELLULAR RESPONSE TO STARVATION 145 4.46e-15 -0.377000 3.48e-13
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 1.63e-07 -0.376000 4.06e-06
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 14 1.50e-02 0.376000 7.31e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.91e-02 0.375000 8.79e-02
CHOLESTEROL BIOSYNTHESIS 24 1.48e-03 -0.375000 1.15e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 9.70e-04 0.374000 8.00e-03
DEGRADATION OF DVL 56 1.32e-06 -0.374000 2.49e-05
IRAK4 DEFICIENCY TLR2 4 12 2.52e-02 -0.373000 1.09e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 64 2.46e-07 -0.373000 5.75e-06
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.11e-04 -0.373000 2.07e-03
ORC1 REMOVAL FROM CHROMATIN 68 1.23e-07 -0.371000 3.28e-06
INTERLEUKIN 12 FAMILY SIGNALING 44 2.36e-05 -0.368000 3.11e-04
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 3.91e-04 -0.368000 3.61e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 1.70e-04 -0.367000 1.71e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 3.55e-02 0.366000 1.41e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 10 4.56e-02 0.365000 1.66e-01
DEGRADATION OF AXIN 54 3.51e-06 -0.365000 5.95e-05
HEDGEHOG LIGAND BIOGENESIS 62 6.82e-07 -0.365000 1.38e-05
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 4.85e-03 0.364000 3.00e-02
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.35e-03 0.363000 1.07e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.52e-07 -0.363000 3.87e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 4.99e-03 -0.363000 3.04e-02
ANTIGEN PROCESSING CROSS PRESENTATION 94 1.29e-09 -0.362000 6.59e-08
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 6.45e-09 -0.360000 2.84e-07
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 70 1.93e-07 -0.360000 4.64e-06
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 6.52e-04 0.360000 5.78e-03
PROCESSING AND ACTIVATION OF SUMO 10 5.05e-02 -0.357000 1.77e-01
INTERLEUKIN 6 SIGNALING 10 5.11e-02 0.356000 1.78e-01
PENTOSE PHOSPHATE PATHWAY 13 2.62e-02 -0.356000 1.12e-01
MITOCHONDRIAL PROTEIN IMPORT 63 1.02e-06 -0.356000 1.95e-05
DEGRADATION OF GLI1 BY THE PROTEASOME 58 2.72e-06 -0.356000 4.76e-05
INFLUENZA INFECTION 145 1.76e-13 -0.354000 1.21e-11
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.01e-03 0.354000 3.04e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 1.67e-06 0.352000 3.00e-05
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 4.34e-02 -0.352000 1.60e-01
G1 S DNA DAMAGE CHECKPOINTS 66 8.55e-07 -0.350000 1.70e-05
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 5.89e-08 -0.349000 1.87e-06
PINK1 PRKN MEDIATED MITOPHAGY 22 4.70e-03 -0.348000 2.94e-02
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 3.68e-02 -0.348000 1.44e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 5.75e-02 -0.347000 1.97e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 2.02e-02 0.346000 9.12e-02
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 3.66e-03 -0.343000 2.42e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.78e-05 -0.339000 3.58e-04
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 1.45e-06 -0.338000 2.70e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 1.10e-02 -0.337000 5.81e-02
CELLULAR RESPONSE TO HYPOXIA 73 6.85e-07 -0.336000 1.38e-05
HDMS DEMETHYLATE HISTONES 27 2.68e-03 0.334000 1.88e-02
PROTEIN UBIQUITINATION 69 1.64e-06 -0.334000 3.00e-05
COLLAGEN CHAIN TRIMERIZATION 39 3.18e-04 0.333000 2.97e-03
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 8.47e-06 -0.332000 1.26e-04
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.28e-02 -0.330000 6.47e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 4.26e-07 -0.329000 9.25e-06
CITRIC ACID CYCLE TCA CYCLE 22 7.64e-03 -0.329000 4.30e-02
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 4.04e-02 0.328000 1.54e-01
PHOSPHORYLATION OF THE APC C 17 1.91e-02 -0.328000 8.79e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.45e-03 -0.328000 3.67e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 4.10e-02 0.327000 1.56e-01
PRE NOTCH PROCESSING IN GOLGI 18 1.71e-02 0.325000 8.12e-02
CHAPERONE MEDIATED AUTOPHAGY 20 1.22e-02 -0.324000 6.26e-02
RHOBTB3 ATPASE CYCLE 10 7.63e-02 -0.324000 2.38e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 4.34e-02 0.324000 1.60e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 53 4.74e-05 0.323000 5.74e-04
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 1.04e-02 -0.323000 5.53e-02
DNA REPLICATION PRE INITIATION 80 6.72e-07 -0.321000 1.38e-05
SIGNALING BY ROBO RECEPTORS 206 2.92e-15 -0.319000 2.44e-13
RRNA PROCESSING 194 2.53e-14 -0.317000 1.85e-12
AMINE LIGAND BINDING RECEPTORS 29 3.15e-03 0.317000 2.15e-02
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 1.12e-04 -0.316000 1.17e-03
NEPHRIN FAMILY INTERACTIONS 22 1.03e-02 0.316000 5.50e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.48e-02 -0.315000 7.26e-02
CELLULAR HEXOSE TRANSPORT 11 7.24e-02 0.313000 2.30e-01
INSULIN RECEPTOR RECYCLING 20 1.68e-02 -0.309000 8.04e-02
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 4.32e-03 -0.306000 2.78e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.90e-02 0.306000 2.42e-01
PYROPTOSIS 21 1.54e-02 -0.305000 7.44e-02
REPRESSION OF WNT TARGET GENES 14 4.83e-02 0.305000 1.73e-01
REGULATION OF RAS BY GAPS 67 1.69e-05 -0.304000 2.36e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 5.80e-02 -0.304000 1.98e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.88e-02 -0.303000 8.72e-02
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 9.78e-02 0.302000 2.75e-01
LONG TERM POTENTIATION 23 1.21e-02 0.302000 6.26e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 5.51e-05 0.301000 6.45e-04
REGULATION OF BACH1 ACTIVITY 11 8.45e-02 -0.300000 2.53e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 11 8.46e-02 -0.300000 2.53e-01
DNA REPLICATION 122 1.12e-08 -0.300000 4.36e-07
REGULATION OF PTEN STABILITY AND ACTIVITY 67 2.43e-05 -0.298000 3.17e-04
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 37 1.70e-03 0.298000 1.28e-02
NEUREXINS AND NEUROLIGINS 54 1.51e-04 0.298000 1.54e-03
SYNTHESIS OF PE 13 6.34e-02 0.297000 2.10e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 5.07e-03 -0.296000 3.06e-02
COLLAGEN FORMATION 78 7.45e-06 0.294000 1.13e-04
METABOLISM OF AMINO ACIDS AND DERIVATIVES 316 3.30e-19 -0.293000 4.83e-17
INTERLEUKIN 20 FAMILY SIGNALING 13 6.78e-02 0.293000 2.20e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 4.06e-06 -0.291000 6.79e-05
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 5.12e-02 0.291000 1.78e-01
CDC42 GTPASE CYCLE 152 6.33e-10 0.291000 3.37e-08
RAS PROCESSING 24 1.40e-02 -0.290000 6.89e-02
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.77e-03 0.288000 2.97e-02
ABC TRANSPORTER DISORDERS 69 3.50e-05 -0.288000 4.40e-04
RHOB GTPASE CYCLE 67 4.75e-05 0.287000 5.74e-04
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 5.35e-06 -0.287000 8.58e-05
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 2.26e-05 0.287000 3.04e-04
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 1.00e-01 -0.286000 2.79e-01
FCERI MEDIATED NF KB ACTIVATION 77 1.74e-05 -0.283000 2.39e-04
LGI ADAM INTERACTIONS 14 6.71e-02 0.283000 2.18e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 6.84e-06 -0.282000 1.07e-04
BRANCHED CHAIN AMINO ACID CATABOLISM 21 2.57e-02 -0.281000 1.10e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 1.31e-02 0.281000 6.56e-02
PURINE CATABOLISM 16 5.19e-02 -0.281000 1.80e-01
INTERLEUKIN 6 FAMILY SIGNALING 19 3.47e-02 0.280000 1.39e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.37e-02 -0.279000 6.81e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 3.61e-02 -0.278000 1.43e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 4.18e-02 -0.277000 1.57e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 5.49e-04 0.277000 4.95e-03
PKMTS METHYLATE HISTONE LYSINES 48 9.40e-04 0.276000 7.87e-03
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 4.30e-02 0.276000 1.60e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 6.52e-02 -0.275000 2.15e-01
ENOS ACTIVATION 11 1.15e-01 -0.275000 3.08e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 8.75e-02 0.274000 2.59e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.98e-02 -0.272000 1.53e-01
METABOLISM OF COFACTORS 18 4.57e-02 -0.272000 1.66e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.66e-05 0.270000 2.34e-04
SCAVENGING BY CLASS A RECEPTORS 13 9.16e-02 -0.270000 2.63e-01
S PHASE 154 7.32e-09 -0.270000 3.06e-07
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.21e-01 -0.270000 3.20e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.52e-02 -0.270000 7.41e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 1.21e-02 -0.269000 6.26e-02
FATTY ACYL COA BIOSYNTHESIS 32 8.42e-03 -0.269000 4.63e-02
REGULATED NECROSIS 46 1.76e-03 -0.267000 1.31e-02
TRP CHANNELS 18 5.24e-02 0.264000 1.81e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 37 5.75e-03 -0.262000 3.38e-02
IRON UPTAKE AND TRANSPORT 52 1.07e-03 -0.262000 8.73e-03
G ALPHA 12 13 SIGNALLING EVENTS 74 9.69e-05 0.262000 1.03e-03
PLATELET ADHESION TO EXPOSED COLLAGEN 11 1.34e-01 -0.261000 3.42e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 3.85e-02 0.261000 1.50e-01
G PROTEIN ACTIVATION 22 3.54e-02 -0.259000 1.41e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 7.99e-03 0.259000 4.48e-02
INTEGRIN SIGNALING 24 2.83e-02 0.259000 1.19e-01
SIGNALING BY FGFR4 IN DISEASE 10 1.57e-01 -0.259000 3.79e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 20 4.58e-02 -0.258000 1.66e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.58e-01 -0.258000 3.81e-01
G2 M CHECKPOINTS 135 2.57e-07 -0.257000 5.90e-06
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 4.68e-02 0.257000 1.68e-01
HSF1 ACTIVATION 25 2.64e-02 -0.256000 1.13e-01
PROTEIN LOCALIZATION 156 3.74e-08 -0.255000 1.25e-06
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.94e-02 -0.255000 8.85e-02
RET SIGNALING 36 8.20e-03 0.255000 4.57e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 1.29e-02 0.254000 6.47e-02
CELLULAR RESPONSE TO CHEMICAL STRESS 150 8.07e-08 -0.254000 2.42e-06
INOSITOL PHOSPHATE METABOLISM 47 2.63e-03 0.254000 1.85e-02
PHASE 2 PLATEAU PHASE 13 1.13e-01 0.254000 3.06e-01
MTORC1 MEDIATED SIGNALLING 24 3.16e-02 -0.253000 1.29e-01
PI METABOLISM 79 1.05e-04 0.253000 1.10e-03
PEPTIDE HORMONE METABOLISM 59 8.10e-04 -0.252000 6.93e-03
LAMININ INTERACTIONS 28 2.13e-02 0.251000 9.44e-02
COLLAGEN DEGRADATION 51 1.92e-03 0.251000 1.40e-02
REGULATION OF BETA CELL DEVELOPMENT 25 2.98e-02 0.251000 1.24e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 1.69e-01 0.251000 3.96e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 9.43e-02 0.250000 2.69e-01
MITOPHAGY 29 2.02e-02 -0.249000 9.12e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 8.76e-05 -0.249000 9.58e-04
VOLTAGE GATED POTASSIUM CHANNELS 40 6.43e-03 0.249000 3.67e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 9.67e-02 -0.248000 2.75e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 8.29e-03 0.248000 4.60e-02
TRAF6 MEDIATED IRF7 ACTIVATION 15 9.73e-02 0.247000 2.75e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 3.53e-05 0.247000 4.40e-04
O LINKED GLYCOSYLATION 87 6.98e-05 0.247000 8.01e-04
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.39e-01 -0.247000 3.53e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 7.12e-02 0.246000 2.27e-01
RHOBTB2 GTPASE CYCLE 23 4.15e-02 -0.246000 1.57e-01
SEPARATION OF SISTER CHROMATIDS 165 5.40e-08 -0.246000 1.76e-06
MET ACTIVATES RAS SIGNALING 10 1.79e-01 -0.245000 4.14e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.00e-01 0.245000 2.79e-01
ACTIVATION OF RAC1 13 1.26e-01 -0.245000 3.28e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 1.82e-01 0.244000 4.14e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 1.28e-01 0.244000 3.32e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 86 9.52e-05 0.244000 1.02e-03
EFFECTS OF PIP2 HYDROLYSIS 27 2.98e-02 0.242000 1.24e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.39e-02 -0.240000 6.87e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.50e-01 -0.240000 3.70e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 7.89e-02 -0.239000 2.42e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 9.79e-02 0.239000 2.75e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 1.71e-01 0.239000 3.98e-01
SIGNALING BY THE B CELL RECEPTOR BCR 104 2.96e-05 -0.237000 3.77e-04
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 1.56e-01 -0.237000 3.77e-01
CALNEXIN CALRETICULIN CYCLE 26 3.68e-02 -0.237000 1.44e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 1.56e-01 -0.236000 3.78e-01
FORMATION OF APOPTOSOME 10 1.96e-01 -0.236000 4.31e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 1.24e-03 -0.235000 1.00e-02
PRE NOTCH EXPRESSION AND PROCESSING 64 1.14e-03 0.235000 9.27e-03
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.99e-01 -0.235000 4.34e-01
METABOLISM OF STEROID HORMONES 20 7.00e-02 -0.234000 2.24e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.45e-01 -0.234000 3.61e-01
MET ACTIVATES RAP1 AND RAC1 11 1.80e-01 -0.234000 4.14e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 4.67e-03 0.234000 2.94e-02
RIPK1 MEDIATED REGULATED NECROSIS 25 4.33e-02 -0.234000 1.60e-01
CARNITINE METABOLISM 14 1.30e-01 0.234000 3.36e-01
RAB GERANYLGERANYLATION 59 2.02e-03 -0.232000 1.47e-02
MITOTIC G1 PHASE AND G1 S TRANSITION 141 1.93e-06 -0.232000 3.43e-05
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.71e-02 -0.231000 2.18e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 2.66e-02 -0.230000 1.13e-01
CYTOPROTECTION BY HMOX1 120 1.40e-05 -0.230000 2.03e-04
ECM PROTEOGLYCANS 66 1.27e-03 0.229000 1.02e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 1.52e-01 0.229000 3.73e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 1.52e-01 -0.229000 3.73e-01
SHC MEDIATED CASCADE FGFR4 11 1.88e-01 -0.229000 4.23e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 2.10e-01 -0.229000 4.50e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 8.44e-02 -0.229000 2.53e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 3.03e-02 0.229000 1.25e-01
OLFACTORY SIGNALING PATHWAY 30 3.04e-02 -0.228000 1.25e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 2.55e-02 0.228000 1.10e-01
RAC1 GTPASE CYCLE 176 1.94e-07 0.228000 4.64e-06
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 1.92e-01 -0.227000 4.26e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 106 5.64e-05 0.227000 6.54e-04
CLEC7A DECTIN 1 SIGNALING 95 1.40e-04 -0.226000 1.45e-03
TERMINATION OF TRANSLESION DNA SYNTHESIS 31 3.01e-02 -0.225000 1.25e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 1.45e-01 -0.225000 3.61e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 3.97e-02 -0.225000 1.53e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 5.81e-02 -0.223000 1.98e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 5.94e-03 0.223000 3.48e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 4.95e-02 0.223000 1.75e-01
CELL CYCLE CHECKPOINTS 243 2.90e-09 -0.221000 1.36e-07
TNFR2 NON CANONICAL NF KB PATHWAY 83 4.99e-04 -0.221000 4.53e-03
INACTIVATION OF CSF3 G CSF SIGNALING 24 6.18e-02 -0.220000 2.07e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 2.71e-04 -0.219000 2.58e-03
ERBB2 ACTIVATES PTK6 SIGNALING 10 2.33e-01 0.218000 4.80e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 111 7.59e-05 -0.218000 8.54e-04
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.78e-02 -0.217000 8.29e-02
DEATH RECEPTOR SIGNALLING 133 1.63e-05 0.217000 2.33e-04
CYTOSOLIC TRNA AMINOACYLATION 24 6.65e-02 -0.216000 2.17e-01
C TYPE LECTIN RECEPTORS CLRS 113 7.21e-05 -0.216000 8.20e-04
TIE2 SIGNALING 17 1.23e-01 -0.216000 3.23e-01
DAG AND IP3 SIGNALING 40 1.83e-02 0.216000 8.53e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 7.40e-02 -0.215000 2.34e-01
NETRIN 1 SIGNALING 48 1.01e-02 0.215000 5.39e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 8.69e-03 0.215000 4.72e-02
GAP JUNCTION ASSEMBLY 22 8.19e-02 -0.214000 2.50e-01
HOST INTERACTIONS OF HIV FACTORS 124 3.90e-05 -0.214000 4.81e-04
RHOC GTPASE CYCLE 73 1.62e-03 0.213000 1.23e-02
PROGRAMMED CELL DEATH 187 5.07e-07 -0.213000 1.08e-05
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 1.17e-01 0.213000 3.13e-01
P75NTR REGULATES AXONOGENESIS 10 2.45e-01 -0.212000 4.89e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 6.15e-02 0.212000 2.06e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.04e-01 0.212000 4.41e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.11e-01 -0.211000 3.01e-01
O LINKED GLYCOSYLATION OF MUCINS 40 2.12e-02 0.211000 9.42e-02
SIGNALING BY NOTCH1 75 1.61e-03 0.211000 1.23e-02
CHROMATIN MODIFYING ENZYMES 218 8.85e-08 0.210000 2.53e-06
GAP JUNCTION DEGRADATION 11 2.30e-01 -0.209000 4.75e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 2.30e-01 0.209000 4.75e-01
RHOBTB1 GTPASE CYCLE 23 8.29e-02 -0.209000 2.52e-01
TCR SIGNALING 101 2.97e-04 -0.208000 2.80e-03
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 1.63e-01 0.208000 3.83e-01
SMOOTH MUSCLE CONTRACTION 33 3.90e-02 -0.208000 1.51e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.08e-01 0.208000 2.95e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 30 4.94e-02 0.207000 1.75e-01
MITOTIC METAPHASE AND ANAPHASE 206 2.97e-07 -0.207000 6.70e-06
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 2.14e-01 -0.207000 4.52e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 9.35e-02 0.207000 2.68e-01
GP1B IX V ACTIVATION SIGNALLING 10 2.60e-01 0.206000 5.03e-01
GLYCOGEN METABOLISM 25 7.52e-02 -0.206000 2.35e-01
G2 M DNA DAMAGE CHECKPOINT 65 4.23e-03 -0.205000 2.74e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 2.18e-01 0.205000 4.57e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 8.10e-05 -0.205000 9.03e-04
PHASE II CONJUGATION OF COMPOUNDS 61 5.68e-03 -0.205000 3.36e-02
ANCHORING FIBRIL FORMATION 14 1.87e-01 0.204000 4.21e-01
APOPTOSIS 165 6.55e-06 -0.204000 1.04e-04
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 9.15e-02 -0.203000 2.63e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 2.43e-01 0.203000 4.88e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 7.49e-02 -0.202000 2.35e-01
MEIOTIC RECOMBINATION 38 3.19e-02 -0.201000 1.30e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.12e-01 -0.200000 3.04e-01
INTRA GOLGI TRAFFIC 43 2.32e-02 0.200000 1.02e-01
GLUCAGON TYPE LIGAND RECEPTORS 25 8.34e-02 -0.200000 2.52e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 2.31e-01 -0.200000 4.75e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 1.96e-01 0.200000 4.31e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.74e-02 -0.198000 8.27e-02
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 4.54e-02 -0.198000 1.66e-01
STIMULI SENSING CHANNELS 74 3.22e-03 0.198000 2.17e-02
EXTRACELLULAR MATRIX ORGANIZATION 240 1.39e-07 0.198000 3.61e-06
PHASE 0 RAPID DEPOLARISATION 29 6.61e-02 0.197000 2.17e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 9.02e-02 -0.196000 2.61e-01
SIGNALING BY NOTCH4 83 2.10e-03 -0.195000 1.52e-02
DNA DAMAGE BYPASS 47 2.11e-02 -0.195000 9.41e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 2.90e-01 -0.193000 5.28e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.67e-01 0.193000 5.11e-01
LAGGING STRAND SYNTHESIS 20 1.35e-01 -0.193000 3.44e-01
UCH PROTEINASES 90 1.57e-03 -0.193000 1.20e-02
NUCLEAR IMPORT OF REV PROTEIN 32 5.94e-02 0.193000 2.01e-01
MAPK6 MAPK4 SIGNALING 84 2.32e-03 -0.192000 1.66e-02
PLATELET AGGREGATION PLUG FORMATION 32 6.01e-02 0.192000 2.02e-01
PHOSPHOLIPID METABOLISM 185 6.98e-06 0.192000 1.08e-04
GLYCOGEN STORAGE DISEASES 12 2.53e-01 -0.191000 4.96e-01
KILLING MECHANISMS 10 2.97e-01 0.190000 5.35e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 8.83e-02 0.190000 2.59e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 38 4.37e-02 -0.189000 1.61e-01
REGULATION OF IFNG SIGNALING 13 2.38e-01 -0.189000 4.84e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.62e-02 0.189000 1.43e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 1.54e-01 -0.189000 3.76e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.18e-01 0.188000 3.15e-01
TRANSCRIPTIONAL REGULATION BY MECP2 60 1.18e-02 0.188000 6.20e-02
SIGNALING BY NOTCH2 33 6.24e-02 0.187000 2.08e-01
TRIGLYCERIDE METABOLISM 23 1.20e-01 -0.187000 3.19e-01
BIOTIN TRANSPORT AND METABOLISM 11 2.83e-01 0.187000 5.23e-01
RMTS METHYLATE HISTONE ARGININES 43 3.40e-02 0.187000 1.37e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.96e-01 0.187000 4.31e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 4.98e-02 0.186000 1.75e-01
METABOLISM OF RNA 644 9.59e-16 -0.186000 9.36e-14
MET ACTIVATES PTK2 SIGNALING 29 8.28e-02 0.186000 2.52e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 1.23e-01 0.186000 3.23e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 2.86e-01 0.186000 5.25e-01
RHO GTPASES ACTIVATE KTN1 11 2.87e-01 -0.185000 5.26e-01
MRNA SPLICING 188 1.23e-05 -0.185000 1.80e-04
RHOA GTPASE CYCLE 141 1.51e-04 0.185000 1.54e-03
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 1.35e-01 -0.184000 3.45e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 2.18e-01 0.184000 4.56e-01
RHOBTB GTPASE CYCLE 35 6.02e-02 -0.184000 2.02e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.95e-01 0.182000 5.33e-01
INTERLEUKIN 15 SIGNALING 12 2.74e-01 0.182000 5.16e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 1.60e-01 0.182000 3.82e-01
DARPP 32 EVENTS 23 1.32e-01 -0.181000 3.39e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 8.08e-02 0.181000 2.47e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 3.21e-01 0.181000 5.62e-01
REGULATED PROTEOLYSIS OF P75NTR 12 2.80e-01 0.180000 5.20e-01
DSCAM INTERACTIONS 10 3.24e-01 0.180000 5.65e-01
SIGNALING BY FGFR2 IN DISEASE 36 6.22e-02 -0.180000 2.08e-01
POLYMERASE SWITCHING 14 2.45e-01 -0.179000 4.89e-01
SHC1 EVENTS IN EGFR SIGNALING 10 3.27e-01 -0.179000 5.68e-01
FATTY ACID METABOLISM 145 2.10e-04 -0.178000 2.07e-03
SIGNALING BY NOTCH3 48 3.25e-02 0.178000 1.32e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 2.50e-01 0.178000 4.93e-01
SIGNALING BY CSF3 G CSF 29 9.79e-02 -0.178000 2.75e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 2.36e-01 -0.177000 4.83e-01
INWARDLY RECTIFYING K CHANNELS 31 8.86e-02 -0.177000 2.59e-01
RHO GTPASES ACTIVATE PKNS 47 3.68e-02 -0.176000 1.44e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.96e-01 0.176000 4.31e-01
MITOTIC SPINDLE CHECKPOINT 96 3.00e-03 -0.175000 2.06e-02
HIV INFECTION 220 7.95e-06 -0.175000 1.19e-04
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 2.04e-02 0.175000 9.13e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 1.04e-01 0.175000 2.85e-01
FRS MEDIATED FGFR4 SIGNALING 13 2.76e-01 -0.174000 5.17e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 8.83e-02 -0.174000 2.59e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 6.85e-02 0.173000 2.21e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.81e-01 0.173000 4.14e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 1.19e-02 -0.173000 6.23e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 3.45e-01 0.172000 5.86e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 1.45e-01 -0.172000 3.61e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 92 4.43e-03 -0.172000 2.84e-02
ION TRANSPORT BY P TYPE ATPASES 48 3.99e-02 0.171000 1.53e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 1.55e-01 -0.171000 3.77e-01
RHOU GTPASE CYCLE 33 8.85e-02 0.171000 2.59e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.55e-01 -0.171000 3.77e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 8.44e-02 0.171000 2.53e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 1.65e-01 -0.171000 3.87e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 16 2.37e-01 -0.171000 4.84e-01
SIGNAL AMPLIFICATION 30 1.06e-01 -0.171000 2.89e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.34e-02 -0.171000 1.03e-01
HIV TRANSCRIPTION INITIATION 45 4.77e-02 -0.171000 1.71e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 1.26e-01 0.170000 3.27e-01
DISEASES OF GLYCOSYLATION 126 9.67e-04 0.170000 8.00e-03
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 1.59e-01 0.170000 3.82e-01
FGFR2 LIGAND BINDING AND ACTIVATION 11 3.31e-01 -0.169000 5.72e-01
RNA POLYMERASE III CHAIN ELONGATION 18 2.14e-01 -0.169000 4.52e-01
GLUTATHIONE CONJUGATION 29 1.15e-01 -0.169000 3.08e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 598 3.12e-12 -0.167000 1.83e-10
NEUTROPHIL DEGRANULATION 384 1.96e-08 -0.167000 7.17e-07
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 1.58e-01 -0.166000 3.81e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 3.02e-01 -0.165000 5.40e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 3.16e-03 0.165000 2.15e-02
SIGNALING BY PDGF 57 3.10e-02 0.165000 1.27e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 15 2.68e-01 0.165000 5.12e-01
OTHER SEMAPHORIN INTERACTIONS 19 2.14e-01 0.165000 4.52e-01
GABA RECEPTOR ACTIVATION 53 3.84e-02 -0.164000 1.50e-01
ASSEMBLY OF THE HIV VIRION 16 2.55e-01 -0.164000 4.97e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 1.73e-01 0.164000 4.03e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 1.28e-02 0.164000 6.47e-02
MISMATCH REPAIR 14 2.92e-01 -0.163000 5.28e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.90e-02 0.162000 2.22e-01
G PROTEIN BETA GAMMA SIGNALLING 30 1.26e-01 -0.162000 3.27e-01
CA DEPENDENT EVENTS 36 9.39e-02 0.161000 2.68e-01
RHOH GTPASE CYCLE 37 8.97e-02 -0.161000 2.61e-01
INTERLEUKIN 1 SIGNALING 96 6.36e-03 -0.161000 3.67e-02
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 2.31e-03 0.161000 1.66e-02
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.84e-01 0.160000 4.17e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 3.19e-01 0.160000 5.60e-01
THE PHOTOTRANSDUCTION CASCADE 21 2.05e-01 -0.160000 4.41e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 4.32e-02 -0.159000 1.60e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.61e-01 -0.159000 6.05e-01
GAB1 SIGNALOSOME 13 3.21e-01 0.159000 5.62e-01
FRS MEDIATED FGFR2 SIGNALING 18 2.43e-01 -0.159000 4.88e-01
PROTEIN FOLDING 89 9.73e-03 -0.159000 5.23e-02
COHESIN LOADING ONTO CHROMATIN 10 3.85e-01 -0.159000 6.32e-01
NUCLEAR ENVELOPE BREAKDOWN 49 5.52e-02 0.158000 1.90e-01
KINESINS 48 5.86e-02 0.158000 1.99e-01
INSULIN PROCESSING 24 1.81e-01 -0.158000 4.14e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 4.12e-02 0.158000 1.56e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.44e-01 -0.158000 5.86e-01
RHO GTPASES ACTIVATE ROCKS 19 2.39e-01 -0.156000 4.84e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 2.85e-01 -0.154000 5.24e-01
RND2 GTPASE CYCLE 38 9.98e-02 0.154000 2.79e-01
SIGNALING BY EGFR IN CANCER 21 2.22e-01 -0.154000 4.62e-01
SIGNALING BY FGFR2 IIIA TM 19 2.45e-01 -0.154000 4.89e-01
INFLAMMASOMES 19 2.49e-01 -0.153000 4.91e-01
RHOV GTPASE CYCLE 32 1.35e-01 0.153000 3.44e-01
GAP JUNCTION TRAFFICKING AND REGULATION 34 1.23e-01 -0.153000 3.23e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 1.65e-02 0.152000 7.91e-02
PCP CE PATHWAY 91 1.21e-02 -0.152000 6.26e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 2.07e-01 -0.152000 4.44e-01
METALLOPROTEASE DUBS 26 1.79e-01 -0.152000 4.14e-01
CHROMOSOME MAINTENANCE 101 8.70e-03 -0.151000 4.72e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 1.63e-01 -0.150000 3.83e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 3.91e-01 -0.149000 6.36e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 1.89e-01 -0.149000 4.23e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 2.88e-01 0.149000 5.27e-01
BIOLOGICAL OXIDATIONS 122 4.56e-03 -0.149000 2.90e-02
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 2.62e-01 -0.149000 5.03e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 2.38e-01 0.149000 4.84e-01
RECEPTOR MEDIATED MITOPHAGY 11 3.94e-01 -0.149000 6.37e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 7.55e-02 0.148000 2.36e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 1.42e-01 -0.148000 3.57e-01
DISEASES OF MITOTIC CELL CYCLE 37 1.20e-01 -0.148000 3.19e-01
TRAFFICKING OF AMPA RECEPTORS 31 1.55e-01 0.148000 3.77e-01
MRNA SPLICING MINOR PATHWAY 52 6.59e-02 -0.147000 2.17e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 2.11e-01 -0.147000 4.50e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 3.97e-01 -0.147000 6.40e-01
CARDIAC CONDUCTION 108 8.69e-03 0.146000 4.72e-02
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 2.25e-01 -0.146000 4.68e-01
TNF SIGNALING 43 9.81e-02 0.146000 2.75e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 1.30e-01 -0.146000 3.36e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 2.37e-01 0.146000 4.84e-01
INTERLEUKIN 10 SIGNALING 20 2.60e-01 -0.146000 5.03e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 1.48e-01 0.145000 3.65e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 4.26e-01 -0.145000 6.61e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 3.31e-01 0.145000 5.72e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.02e-01 -0.145000 5.40e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 1.60e-01 0.144000 3.82e-01
LYSOSOME VESICLE BIOGENESIS 32 1.62e-01 -0.143000 3.83e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 1.91e-01 0.143000 4.25e-01
ONCOGENE INDUCED SENESCENCE 32 1.63e-01 0.143000 3.83e-01
RHO GTPASES ACTIVATE PAKS 21 2.58e-01 -0.143000 5.02e-01
CD28 DEPENDENT PI3K AKT SIGNALING 20 2.71e-01 0.142000 5.13e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 80 2.81e-02 -0.142000 1.19e-01
G PROTEIN MEDIATED EVENTS 52 7.68e-02 0.142000 2.39e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.85e-01 -0.142000 5.24e-01
SYNTHESIS OF PA 29 1.87e-01 0.142000 4.21e-01
SARS COV 1 INFECTION 48 9.01e-02 -0.141000 2.61e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 2.04e-01 -0.141000 4.41e-01
HATS ACETYLATE HISTONES 92 1.92e-02 0.141000 8.79e-02
SIGNALING BY WNT IN CANCER 30 1.81e-01 0.141000 4.14e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 65 4.98e-02 -0.141000 1.75e-01
APOPTOTIC EXECUTION PHASE 45 1.03e-01 -0.141000 2.84e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 4.20e-01 0.140000 6.57e-01
SHC MEDIATED CASCADE FGFR1 14 3.63e-01 -0.140000 6.07e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 1.24e-02 0.140000 6.36e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 3.33e-01 0.140000 5.74e-01
SIGNALLING TO RAS 18 3.08e-01 0.139000 5.47e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 4.05e-01 0.139000 6.43e-01
INTERLEUKIN 7 SIGNALING 20 2.84e-01 0.139000 5.24e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 4.67e-02 -0.139000 1.68e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 1.02e-01 -0.138000 2.83e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 1.92e-01 -0.138000 4.26e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 2.70e-04 -0.138000 2.58e-03
PURINE SALVAGE 12 4.10e-01 -0.137000 6.48e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 2.01e-01 0.137000 4.36e-01
SHC MEDIATED CASCADE FGFR3 13 3.92e-01 -0.137000 6.37e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 3.94e-01 0.136000 6.37e-01
RND3 GTPASE CYCLE 38 1.46e-01 0.136000 3.63e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 1.82e-01 0.136000 4.14e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 4.57e-01 0.136000 6.87e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 9.11e-02 -0.135000 2.63e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 7.75e-02 0.135000 2.40e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 188 1.41e-03 0.135000 1.11e-02
COMPLEMENT CASCADE 24 2.52e-01 -0.135000 4.95e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 8.71e-02 0.135000 2.58e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 2.77e-01 0.134000 5.17e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 4.05e-01 0.133000 6.43e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 40 1.45e-01 0.133000 3.61e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 2.42e-01 0.133000 4.88e-01
ION CHANNEL TRANSPORT 139 7.60e-03 0.131000 4.30e-02
INFECTIOUS DISEASE 723 2.22e-09 -0.131000 1.08e-07
RHO GTPASE CYCLE 422 4.33e-06 0.131000 7.14e-05
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 1.14e-01 0.131000 3.06e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 23 2.78e-01 -0.131000 5.19e-01
KERATAN SULFATE BIOSYNTHESIS 24 2.70e-01 0.130000 5.13e-01
NOD1 2 SIGNALING PATHWAY 34 1.90e-01 0.130000 4.23e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.37e-01 0.129000 6.72e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 4.02e-01 0.129000 6.42e-01
RESOLUTION OF SISTER CHROMATID COHESION 101 2.48e-02 -0.129000 1.08e-01
ACYL CHAIN REMODELLING OF PS 14 4.03e-01 0.129000 6.43e-01
SENSORY PROCESSING OF SOUND 60 8.56e-02 0.128000 2.54e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 4.42e-01 0.128000 6.76e-01
TP53 REGULATES METABOLIC GENES 85 4.29e-02 -0.127000 1.60e-01
CIRCADIAN CLOCK 68 7.04e-02 0.127000 2.25e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 3.15e-01 0.127000 5.57e-01
INTEGRIN CELL SURFACE INTERACTIONS 71 6.49e-02 0.127000 2.15e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 9.00e-02 0.127000 2.61e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.48e-01 -0.126000 4.90e-01
PROLACTIN RECEPTOR SIGNALING 11 4.71e-01 0.125000 6.95e-01
MITOTIC G2 G2 M PHASES 186 3.22e-03 -0.125000 2.17e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 4.53e-01 -0.125000 6.84e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 53 1.15e-01 0.125000 3.08e-01
PI 3K CASCADE FGFR4 11 4.73e-01 -0.125000 6.95e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 2.64e-01 -0.124000 5.05e-01
TBC RABGAPS 43 1.61e-01 0.123000 3.83e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 2.14e-01 0.123000 4.52e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 2.96e-01 -0.123000 5.34e-01
ELASTIC FIBRE FORMATION 36 2.01e-01 0.123000 4.36e-01
THE NLRP3 INFLAMMASOME 15 4.09e-01 -0.123000 6.48e-01
PI 3K CASCADE FGFR2 16 3.94e-01 -0.123000 6.37e-01
ERK MAPK TARGETS 22 3.19e-01 0.123000 5.61e-01
PEROXISOMAL PROTEIN IMPORT 57 1.10e-01 -0.122000 3.00e-01
LDL CLEARANCE 16 3.97e-01 -0.122000 6.40e-01
ION HOMEOSTASIS 49 1.40e-01 0.122000 3.54e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 2.13e-01 -0.122000 4.52e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.06e-01 0.121000 7.18e-01
INTEGRATION OF ENERGY METABOLISM 98 3.86e-02 0.121000 1.50e-01
METABOLISM OF NUCLEOTIDES 92 4.56e-02 -0.121000 1.66e-01
CHONDROITIN SULFATE BIOSYNTHESIS 19 3.64e-01 0.120000 6.08e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.08e-01 0.120000 4.44e-01
VIRAL MESSENGER RNA SYNTHESIS 42 1.81e-01 0.119000 4.14e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 4.24e-01 -0.119000 6.61e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 1.05e-01 -0.119000 2.87e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 4.26e-01 -0.119000 6.61e-01
HS GAG BIOSYNTHESIS 30 2.61e-01 0.118000 5.03e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 2.62e-01 -0.118000 5.03e-01
FCERI MEDIATED MAPK ACTIVATION 28 2.79e-01 -0.118000 5.20e-01
HCMV EARLY EVENTS 80 6.80e-02 0.118000 2.20e-01
MUCOPOLYSACCHARIDOSES 11 4.98e-01 0.118000 7.11e-01
DNA STRAND ELONGATION 32 2.49e-01 -0.118000 4.91e-01
M PHASE 339 2.06e-04 -0.118000 2.06e-03
ADHERENS JUNCTIONS INTERACTIONS 29 2.73e-01 -0.118000 5.15e-01
RA BIOSYNTHESIS PATHWAY 14 4.47e-01 -0.118000 6.80e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 139 1.76e-02 -0.117000 8.29e-02
PLASMA LIPOPROTEIN REMODELING 15 4.34e-01 -0.117000 6.68e-01
HEME BIOSYNTHESIS 13 4.68e-01 0.116000 6.95e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 1.77e-01 0.116000 4.11e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 2.34e-01 0.116000 4.80e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 3.28e-01 0.115000 5.68e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 1.77e-01 0.115000 4.11e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 5.29e-01 -0.115000 7.31e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 1.93e-01 -0.115000 4.26e-01
GLYCOSAMINOGLYCAN METABOLISM 115 3.45e-02 0.114000 1.39e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.86e-01 -0.114000 4.20e-01
ARACHIDONIC ACID METABOLISM 39 2.18e-01 -0.114000 4.57e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.78e-01 0.114000 6.25e-01
HS GAG DEGRADATION 21 3.67e-01 0.114000 6.11e-01
ANTIMICROBIAL PEPTIDES 13 4.78e-01 -0.114000 6.99e-01
SARS COV 2 INFECTION 65 1.14e-01 -0.113000 3.08e-01
INNATE IMMUNE SYSTEM 773 9.89e-08 -0.113000 2.76e-06
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 35 2.46e-01 0.113000 4.90e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 3.94e-01 0.113000 6.37e-01
MHC CLASS II ANTIGEN PRESENTATION 102 4.87e-02 -0.113000 1.73e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.49e-01 -0.113000 5.91e-01
AQUAPORIN MEDIATED TRANSPORT 40 2.17e-01 -0.113000 4.56e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 5.18e-01 0.113000 7.30e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 2.13e-01 0.112000 4.52e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 144 2.02e-02 -0.112000 9.12e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 4.38e-01 0.112000 6.72e-01
SEMAPHORIN INTERACTIONS 64 1.23e-01 0.112000 3.23e-01
HEDGEHOG ON STATE 83 7.91e-02 -0.112000 2.42e-01
MET PROMOTES CELL MOTILITY 39 2.30e-01 0.111000 4.75e-01
SULFUR AMINO ACID METABOLISM 22 3.68e-01 -0.111000 6.12e-01
NUCLEOBASE CATABOLISM 31 2.90e-01 -0.110000 5.28e-01
NEDDYLATION 218 5.37e-03 -0.110000 3.23e-02
MYOGENESIS 25 3.43e-01 0.110000 5.86e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 24 3.54e-01 -0.109000 5.96e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 5.32e-01 0.109000 7.33e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 3.89e-01 -0.109000 6.35e-01
SIGNALING BY ERYTHROPOIETIN 24 3.59e-01 0.108000 6.02e-01
PEXOPHAGY 11 5.35e-01 0.108000 7.34e-01
ONCOGENIC MAPK SIGNALING 77 1.02e-01 0.108000 2.82e-01
PI3K AKT SIGNALING IN CANCER 87 8.45e-02 0.107000 2.53e-01
FRS MEDIATED FGFR1 SIGNALING 16 4.59e-01 -0.107000 6.89e-01
PLATELET CALCIUM HOMEOSTASIS 27 3.39e-01 0.106000 5.82e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 1.90e-01 0.106000 4.23e-01
STRIATED MUSCLE CONTRACTION 28 3.33e-01 -0.106000 5.75e-01
PYRIMIDINE CATABOLISM 10 5.65e-01 -0.105000 7.50e-01
CELL CYCLE MITOTIC 474 9.41e-05 -0.105000 1.02e-03
REGULATION OF TNFR1 SIGNALING 34 2.93e-01 0.104000 5.30e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 11 5.50e-01 -0.104000 7.40e-01
KERATAN SULFATE DEGRADATION 11 5.53e-01 -0.103000 7.42e-01
MITOTIC TELOPHASE CYTOKINESIS 13 5.22e-01 -0.103000 7.31e-01
HEME SIGNALING 44 2.39e-01 0.103000 4.85e-01
NEURONAL SYSTEM 366 7.97e-04 0.102000 6.86e-03
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.53e-01 0.102000 6.84e-01
MEIOSIS 63 1.61e-01 -0.102000 3.83e-01
PEPTIDE LIGAND BINDING RECEPTORS 94 8.81e-02 -0.102000 2.59e-01
FRS MEDIATED FGFR3 SIGNALING 15 4.95e-01 -0.102000 7.08e-01
CTLA4 INHIBITORY SIGNALING 20 4.31e-01 -0.102000 6.65e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 343 1.29e-03 -0.101000 1.02e-02
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 2.62e-01 0.101000 5.03e-01
SIGNALING BY RETINOIC ACID 34 3.07e-01 -0.101000 5.46e-01
PERK REGULATES GENE EXPRESSION 28 3.55e-01 -0.101000 5.96e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 5.29e-01 -0.101000 7.31e-01
INTERLEUKIN 1 FAMILY SIGNALING 122 5.50e-02 -0.101000 1.89e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 5.30e-01 0.101000 7.31e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.41e-01 0.100000 5.85e-01
L1CAM INTERACTIONS 107 7.29e-02 0.100000 2.31e-01
KERATAN SULFATE KERATIN METABOLISM 30 3.42e-01 0.100000 5.85e-01
GLUCONEOGENESIS 27 3.69e-01 -0.099800 6.13e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 5.50e-01 -0.099700 7.40e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 4.65e-01 0.099400 6.94e-01
MICRORNA MIRNA BIOGENESIS 24 4.00e-01 0.099400 6.40e-01
SIGNALING BY NTRK3 TRKC 17 4.78e-01 0.099300 6.99e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 5.37e-01 0.098900 7.36e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 5.22e-01 0.098900 7.31e-01
INTERLEUKIN 27 SIGNALING 10 5.88e-01 0.098900 7.66e-01
NICOTINATE METABOLISM 24 4.02e-01 0.098900 6.42e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 5.23e-01 -0.098700 7.31e-01
CELL CYCLE 591 4.96e-05 -0.098100 5.92e-04
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 5.26e-01 0.097900 7.31e-01
PEROXISOMAL LIPID METABOLISM 26 3.89e-01 -0.097700 6.35e-01
SIGNALING BY EGFR 46 2.52e-01 0.097600 4.95e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 25 4.00e-01 -0.097400 6.40e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 5.44e-01 0.097200 7.40e-01
TELOMERE MAINTENANCE 78 1.39e-01 -0.097000 3.53e-01
REPRODUCTION 75 1.48e-01 -0.096800 3.65e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 4.55e-01 -0.096600 6.85e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 5.04e-01 -0.096500 7.16e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 1.80e-01 -0.096200 4.14e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 4.47e-01 -0.095900 6.80e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 3.14e-01 -0.095700 5.57e-01
RND1 GTPASE CYCLE 37 3.16e-01 0.095400 5.57e-01
SODIUM CALCIUM EXCHANGERS 10 6.02e-01 0.095400 7.77e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 5.23e-01 -0.095300 7.31e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 4.53e-01 0.094500 6.84e-01
INITIAL TRIGGERING OF COMPLEMENT 11 5.88e-01 0.094400 7.66e-01
HDACS DEACETYLATE HISTONES 46 2.69e-01 0.094200 5.12e-01
SIGNALING BY INSULIN RECEPTOR 61 2.05e-01 -0.094000 4.41e-01
CELL CELL COMMUNICATION 106 9.91e-02 0.092800 2.78e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 58 2.22e-01 -0.092800 4.62e-01
RETROGRADE NEUROTROPHIN SIGNALLING 13 5.63e-01 0.092600 7.50e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.40e-01 0.092500 3.54e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 5.65e-01 -0.092200 7.50e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 25 4.27e-01 -0.091700 6.61e-01
INTERLEUKIN 17 SIGNALING 66 1.98e-01 0.091700 4.33e-01
BILE ACID AND BILE SALT METABOLISM 25 4.28e-01 0.091700 6.61e-01
OXIDATIVE STRESS INDUCED SENESCENCE 78 1.62e-01 0.091600 3.83e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 5.53e-01 0.091600 7.42e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 3.63e-01 -0.091500 6.07e-01
SIGNALING BY INTERLEUKINS 347 3.51e-03 -0.091400 2.34e-02
ERBB2 REGULATES CELL MOTILITY 13 5.69e-01 0.091300 7.51e-01
DUAL INCISION IN TC NER 64 2.08e-01 -0.091100 4.44e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 1.04e-01 -0.091100 2.85e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 4.92e-01 -0.091100 7.07e-01
DAP12 SIGNALING 24 4.41e-01 -0.090800 6.76e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 4.52e-01 -0.090700 6.84e-01
SIGNALING BY GPCR 459 9.23e-04 0.090500 7.78e-03
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.45e-01 -0.090400 7.40e-01
REGULATION OF IFNA SIGNALING 12 5.88e-01 0.090300 7.66e-01
DISEASES OF METABOLISM 201 2.85e-02 0.089700 1.20e-01
G ALPHA S SIGNALLING EVENTS 98 1.26e-01 0.089600 3.27e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 4.89e-01 0.089300 7.05e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 1.62e-01 -0.088900 3.83e-01
HYALURONAN METABOLISM 15 5.52e-01 0.088600 7.42e-01
TRANSCRIPTION OF THE HIV GENOME 67 2.12e-01 -0.088200 4.51e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 10 6.30e-01 -0.088100 7.96e-01
SELECTIVE AUTOPHAGY 71 2.00e-01 -0.087900 4.36e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 5.21e-01 -0.087400 7.31e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 2.40e-01 0.087000 4.86e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 19 5.12e-01 -0.086900 7.23e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 5.12e-01 -0.086900 7.23e-01
ZINC TRANSPORTERS 16 5.49e-01 -0.086500 7.40e-01
MAP2K AND MAPK ACTIVATION 36 3.71e-01 0.086100 6.15e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 5.64e-01 -0.085900 7.50e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.31e-01 -0.085900 4.76e-01
FORMATION OF THE CORNIFIED ENVELOPE 29 4.26e-01 0.085400 6.61e-01
KERATINIZATION 29 4.26e-01 0.085400 6.61e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 4.27e-01 -0.085300 6.61e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 6.10e-01 -0.085100 7.83e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 6.25e-01 0.085100 7.95e-01
DISEASES OF PROGRAMMED CELL DEATH 54 2.80e-01 -0.085000 5.20e-01
SIGNALING BY KIT IN DISEASE 20 5.12e-01 -0.084700 7.23e-01
FGFR2 ALTERNATIVE SPLICING 25 4.63e-01 -0.084700 6.94e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 4.15e-01 -0.084500 6.54e-01
JOSEPHIN DOMAIN DUBS 11 6.27e-01 -0.084500 7.95e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.91e-01 -0.083900 5.28e-01
DEADENYLATION OF MRNA 25 4.68e-01 -0.083800 6.95e-01
HIV LIFE CYCLE 142 8.55e-02 -0.083700 2.54e-01
RHOQ GTPASE CYCLE 57 2.75e-01 0.083600 5.17e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 4.17e-01 0.082900 6.54e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 5.43e-01 -0.082800 7.40e-01
SIGNALING BY FGFR1 42 3.55e-01 -0.082600 5.96e-01
FOXO MEDIATED TRANSCRIPTION 57 2.83e-01 -0.082300 5.23e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 4.90e-01 0.081500 7.05e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 5.75e-01 0.081000 7.57e-01
AMINO ACIDS REGULATE MTORC1 51 3.25e-01 -0.079700 5.65e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 2.64e-01 0.079600 5.05e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 6.06e-01 -0.079500 7.80e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 622 7.50e-04 0.079500 6.55e-03
UB SPECIFIC PROCESSING PROTEASES 169 7.50e-02 -0.079500 2.35e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 43 3.68e-01 -0.079300 6.12e-01
CD209 DC SIGN SIGNALING 18 5.62e-01 -0.079000 7.50e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 31 4.49e-01 0.078700 6.80e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 3.74e-01 0.078300 6.19e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 6.54e-01 0.078000 8.12e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 5.27e-01 -0.078000 7.31e-01
RHO GTPASES ACTIVATE FORMINS 118 1.47e-01 -0.077300 3.65e-01
REGULATION OF KIT SIGNALING 16 5.93e-01 0.077100 7.71e-01
DUAL INCISION IN GG NER 40 3.99e-01 -0.077000 6.40e-01
RAB REGULATION OF TRAFFICKING 119 1.47e-01 0.077000 3.65e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 4.73e-01 -0.077000 6.95e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 7.77e-02 -0.077000 2.40e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 5.94e-01 -0.077000 7.71e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 4.73e-01 0.076900 6.95e-01
PRC2 METHYLATES HISTONES AND DNA 29 4.74e-01 -0.076900 6.95e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 5.23e-01 -0.076900 7.31e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 6.45e-01 0.076800 8.09e-01
N GLYCAN ANTENNAE ELONGATION 15 6.07e-01 0.076700 7.81e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 4.14e-01 -0.076700 6.53e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 6.33e-01 -0.076600 7.98e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 4.18e-01 -0.076000 6.54e-01
SIGNALING BY FGFR2 62 3.02e-01 -0.075800 5.40e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 2.00e-01 0.075800 4.36e-01
EGFR DOWNREGULATION 27 4.96e-01 0.075700 7.09e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 4.81e-01 0.075600 6.99e-01
RHO GTPASES ACTIVATE CIT 18 5.80e-01 -0.075400 7.62e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 6.65e-01 0.075400 8.18e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 3.01e-01 -0.075400 5.40e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 6.51e-01 0.075300 8.12e-01
ADAPTIVE IMMUNE SYSTEM 596 1.85e-03 -0.075000 1.37e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.57e-01 -0.074700 5.01e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.68e-01 0.074700 8.19e-01
NUCLEAR SIGNALING BY ERBB4 30 4.79e-01 0.074700 6.99e-01
METABOLISM OF FOLATE AND PTERINES 15 6.17e-01 0.074600 7.91e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 2.43e-01 0.074600 4.88e-01
AUTOPHAGY 138 1.32e-01 -0.074300 3.39e-01
DAP12 INTERACTIONS 29 4.89e-01 -0.074300 7.05e-01
SIGNALING BY BMP 24 5.30e-01 -0.074100 7.31e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 5.97e-01 0.074000 7.73e-01
SIGNALING BY ACTIVIN 12 6.57e-01 0.074000 8.13e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 31 4.77e-01 0.073800 6.99e-01
ATTENUATION PHASE 23 5.44e-01 -0.073100 7.40e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 3.17e-01 -0.072900 5.59e-01
REGULATION OF FZD BY UBIQUITINATION 19 5.83e-01 -0.072800 7.64e-01
SHC1 EVENTS IN ERBB4 SIGNALING 12 6.63e-01 -0.072700 8.18e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 545 4.02e-03 -0.072300 2.63e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 6.52e-01 -0.072300 8.12e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 4.61e-01 0.072000 6.91e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 6.94e-01 -0.071900 8.37e-01
MRNA CAPPING 29 5.04e-01 -0.071800 7.16e-01
GLUCOSE METABOLISM 81 2.70e-01 0.070900 5.13e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 2.54e-01 -0.070700 4.97e-01
INTERFERON GAMMA SIGNALING 75 2.90e-01 -0.070700 5.28e-01
REGULATION OF SIGNALING BY CBL 22 5.68e-01 -0.070300 7.51e-01
G ALPHA Z SIGNALLING EVENTS 45 4.17e-01 -0.070000 6.54e-01
GENE SILENCING BY RNA 82 2.74e-01 0.070000 5.15e-01
PTEN REGULATION 134 1.62e-01 -0.069900 3.83e-01
CARGO CONCENTRATION IN THE ER 30 5.08e-01 0.069800 7.20e-01
G0 AND EARLY G1 25 5.47e-01 -0.069600 7.40e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 4.39e-02 -0.069400 1.61e-01
ERKS ARE INACTIVATED 13 6.67e-01 0.069000 8.18e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 6.56e-01 0.068700 8.12e-01
PECAM1 INTERACTIONS 12 6.80e-01 0.068700 8.29e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 4.16e-01 -0.068600 6.54e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 4.33e-01 -0.068400 6.66e-01
FERTILIZATION 12 6.85e-01 -0.067700 8.32e-01
AGGREPHAGY 34 4.97e-01 -0.067300 7.10e-01
NONHOMOLOGOUS END JOINING NHEJ 43 4.46e-01 -0.067200 6.80e-01
RESOLUTION OF ABASIC SITES AP SITES 37 4.80e-01 -0.067200 6.99e-01
COSTIMULATION BY THE CD28 FAMILY 49 4.16e-01 -0.067100 6.54e-01
BASE EXCISION REPAIR 56 3.86e-01 -0.067000 6.32e-01
CD28 CO STIMULATION 30 5.27e-01 -0.066700 7.31e-01
GABA B RECEPTOR ACTIVATION 39 4.72e-01 -0.066500 6.95e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 3.82e-01 0.066400 6.29e-01
SIGNALING BY ERBB4 56 3.91e-01 -0.066300 6.36e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 6.46e-01 -0.066200 8.10e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 23 5.83e-01 -0.066100 7.64e-01
GLYCOLYSIS 67 3.50e-01 0.066100 5.92e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 4.44e-01 0.065900 6.78e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 5.46e-01 -0.065900 7.40e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 168 1.41e-01 0.065900 3.55e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 7.20e-01 0.065500 8.51e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 5.98e-01 0.065000 7.73e-01
RHOG GTPASE CYCLE 73 3.39e-01 0.064800 5.82e-01
SARS COV INFECTIONS 140 1.86e-01 -0.064800 4.21e-01
P75NTR SIGNALS VIA NF KB 16 6.54e-01 0.064700 8.12e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 6.26e-01 -0.064700 7.95e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 139 1.89e-01 0.064600 4.23e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 90 2.90e-01 -0.064600 5.28e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 6.20e-01 0.064000 7.93e-01
SIGNALING BY WNT 268 7.21e-02 -0.063900 2.29e-01
PI3K EVENTS IN ERBB2 SIGNALING 14 6.82e-01 0.063200 8.31e-01
SIGNALING BY MET 75 3.45e-01 0.063100 5.86e-01
TRNA AMINOACYLATION 42 4.80e-01 -0.063000 6.99e-01
MATURATION OF NUCLEOPROTEIN 10 7.30e-01 -0.062900 8.55e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 6.26e-01 -0.062900 7.95e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 44 4.73e-01 -0.062500 6.95e-01
POTASSIUM CHANNELS 90 3.06e-01 0.062500 5.45e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 102 2.77e-01 0.062300 5.17e-01
HEDGEHOG OFF STATE 107 2.68e-01 -0.062000 5.12e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 6.72e-01 -0.061100 8.23e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 6.94e-01 0.060700 8.37e-01
FANCONI ANEMIA PATHWAY 36 5.30e-01 0.060500 7.31e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 64 4.04e-01 -0.060300 6.43e-01
SIGNALING BY VEGF 101 3.01e-01 0.059600 5.40e-01
PREGNENOLONE BIOSYNTHESIS 12 7.21e-01 -0.059500 8.51e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 4.72e-01 -0.059500 6.95e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 3.44e-01 0.059400 5.86e-01
MUSCLE CONTRACTION 163 1.92e-01 0.059300 4.26e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 7.12e-01 -0.059200 8.45e-01
SIALIC ACID METABOLISM 32 5.64e-01 -0.058900 7.50e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 7.26e-01 -0.058500 8.52e-01
SIGNALING BY FGFR 72 3.91e-01 -0.058500 6.36e-01
PI 3K CASCADE FGFR1 14 7.05e-01 -0.058500 8.44e-01
MTOR SIGNALLING 40 5.23e-01 -0.058300 7.31e-01
SIGNALING BY NODAL 16 6.87e-01 0.058200 8.32e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 6.89e-01 -0.057900 8.32e-01
GRB2 EVENTS IN ERBB2 SIGNALING 14 7.08e-01 -0.057800 8.45e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 6.40e-01 -0.057500 8.05e-01
PARASITE INFECTION 55 4.64e-01 0.057100 6.94e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 6.84e-01 -0.057100 8.31e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 5.77e-01 0.057000 7.59e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 3.52e-01 0.056800 5.93e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 3.83e-01 0.056800 6.30e-01
EXTENSION OF TELOMERES 49 4.93e-01 -0.056600 7.08e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 6.78e-01 0.056500 8.28e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.46e-01 -0.056400 8.64e-01
SIGNALING BY NTRKS 129 2.71e-01 0.056200 5.13e-01
CELLULAR SENESCENCE 141 2.51e-01 0.056000 4.95e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 4.06e-01 -0.056000 6.43e-01
REGULATION OF TP53 ACTIVITY 151 2.43e-01 0.055100 4.88e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 5.53e-01 0.055000 7.42e-01
SIGNALING BY SCF KIT 41 5.46e-01 0.054500 7.40e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.84e-01 0.054000 7.02e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 6.34e-01 -0.054000 7.99e-01
SIGNALING BY HIPPO 20 6.79e-01 -0.053500 8.28e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 3.79e-01 0.053400 6.25e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 6.19e-01 -0.053400 7.93e-01
SYNTHESIS OF PC 25 6.45e-01 0.053300 8.09e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 459 5.10e-02 0.053300 1.78e-01
TRNA PROCESSING IN THE NUCLEUS 56 4.95e-01 0.052800 7.08e-01
RECYCLING PATHWAY OF L1 40 5.64e-01 0.052700 7.50e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 4.76e-01 -0.052400 6.97e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.51e-01 -0.052300 8.12e-01
NUCLEOBASE BIOSYNTHESIS 15 7.27e-01 -0.052200 8.52e-01
SIGNALING BY PTK6 50 5.24e-01 0.052100 7.31e-01
BASIGIN INTERACTIONS 23 6.66e-01 -0.052100 8.18e-01
RNA POLYMERASE III TRANSCRIPTION 41 5.66e-01 -0.051800 7.50e-01
NUCLEOTIDE EXCISION REPAIR 109 3.51e-01 -0.051800 5.92e-01
RNA POLYMERASE I TRANSCRIPTION 67 4.65e-01 -0.051600 6.94e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 4.42e-01 -0.051000 6.76e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 16 7.24e-01 0.051000 8.52e-01
MITOTIC PROMETAPHASE 176 2.46e-01 -0.050700 4.90e-01
SLC TRANSPORTER DISORDERS 75 4.48e-01 0.050700 6.80e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 5.65e-01 0.050700 7.50e-01
POLO LIKE KINASE MEDIATED EVENTS 14 7.43e-01 0.050500 8.62e-01
PLATELET SENSITIZATION BY LDL 15 7.37e-01 -0.050100 8.60e-01
SIGNALING BY FGFR4 32 6.26e-01 -0.049700 7.95e-01
NUCLEOTIDE SALVAGE 21 6.97e-01 -0.049100 8.39e-01
PI 3K CASCADE FGFR3 13 7.60e-01 -0.048900 8.75e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.70e-01 0.048800 8.82e-01
ESR MEDIATED SIGNALING 163 2.84e-01 -0.048600 5.24e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 7.21e-01 -0.048600 8.51e-01
INTERFERON ALPHA BETA SIGNALING 53 5.47e-01 -0.047800 7.40e-01
PLATELET HOMEOSTASIS 78 4.68e-01 -0.047600 6.95e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 7.37e-01 0.047000 8.60e-01
NICOTINAMIDE SALVAGING 15 7.53e-01 -0.047000 8.70e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 7.69e-01 0.047000 8.82e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 60 5.35e-01 0.046300 7.34e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 5.25e-01 -0.046300 7.31e-01
RESOLUTION OF D LOOP STRUCTURES 30 6.61e-01 0.046300 8.17e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 6.05e-01 0.045700 7.79e-01
INTERFERON SIGNALING 163 3.15e-01 -0.045600 5.57e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 7.38e-01 -0.045600 8.60e-01
COPII MEDIATED VESICLE TRANSPORT 64 5.29e-01 0.045500 7.31e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 238 2.29e-01 0.045300 4.75e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 5.00e-01 -0.045000 7.13e-01
ERYTHROPOIETIN ACTIVATES RAS 13 7.80e-01 -0.044800 8.91e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 5.47e-01 0.044600 7.40e-01
RAC3 GTPASE CYCLE 88 4.71e-01 0.044500 6.95e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 50 5.89e-01 -0.044100 7.67e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 8.09e-01 0.044100 9.03e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 8.09e-01 0.044100 9.03e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 5.72e-01 -0.044100 7.54e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 4.84e-01 0.043600 7.02e-01
ENDOGENOUS STEROLS 20 7.38e-01 -0.043100 8.60e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 6.78e-01 0.043100 8.28e-01
SIGNALING BY NUCLEAR RECEPTORS 221 2.72e-01 -0.042900 5.14e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 6.29e-01 -0.042600 7.96e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 7.99e-01 -0.042400 9.00e-01
HIV TRANSCRIPTION ELONGATION 42 6.36e-01 -0.042200 8.00e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 92 4.86e-01 0.042000 7.04e-01
FLT3 SIGNALING IN DISEASE 27 7.06e-01 -0.042000 8.44e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 6.02e-01 0.041800 7.77e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 7.54e-01 -0.041500 8.71e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 7.09e-01 -0.041500 8.45e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 44 6.35e-01 0.041400 7.99e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 7.57e-01 0.041000 8.73e-01
METABOLISM OF CARBOHYDRATES 259 2.60e-01 0.040700 5.03e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 15 7.86e-01 0.040500 8.94e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 41 6.55e-01 0.040400 8.12e-01
CILIUM ASSEMBLY 190 3.41e-01 0.040100 5.85e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 7.88e-01 -0.040100 8.95e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 7.13e-01 -0.039400 8.46e-01
RNA POLYMERASE II TRANSCRIPTION 1085 2.97e-02 -0.039400 1.24e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 85 5.34e-01 -0.039000 7.34e-01
MET RECEPTOR RECYCLING 10 8.31e-01 -0.039000 9.12e-01
SIGNALING BY FGFR IN DISEASE 55 6.20e-01 -0.038700 7.93e-01
DEUBIQUITINATION 243 3.02e-01 -0.038500 5.40e-01
DNA DAMAGE RECOGNITION IN GG NER 38 6.87e-01 -0.037800 8.32e-01
METABOLISM OF STEROIDS 113 4.89e-01 -0.037700 7.05e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 7.71e-01 -0.037600 8.83e-01
PROLONGED ERK ACTIVATION EVENTS 13 8.15e-01 -0.037500 9.05e-01
NEGATIVE REGULATION OF FLT3 15 8.02e-01 0.037400 9.00e-01
REGULATION OF INSULIN SECRETION 71 5.87e-01 0.037300 7.66e-01
ACYL CHAIN REMODELLING OF PC 17 7.91e-01 0.037200 8.97e-01
HSF1 DEPENDENT TRANSACTIVATION 33 7.18e-01 0.036400 8.50e-01
RAC2 GTPASE CYCLE 86 5.60e-01 0.036400 7.49e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 5.49e-01 0.036200 7.40e-01
SIGNALLING TO ERKS 32 7.24e-01 0.036100 8.52e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 4.06e-01 0.036100 6.43e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.41e-01 0.036000 8.61e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 8.30e-01 -0.035800 9.12e-01
RAF ACTIVATION 34 7.18e-01 -0.035800 8.50e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 6.98e-01 -0.035100 8.39e-01
SHC1 EVENTS IN ERBB2 SIGNALING 20 7.86e-01 0.035000 8.94e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 8.09e-01 0.034900 9.03e-01
HCMV INFECTION 103 5.42e-01 0.034800 7.40e-01
EPHRIN SIGNALING 19 7.93e-01 0.034700 8.98e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 8.04e-01 -0.034700 9.00e-01
DERMATAN SULFATE BIOSYNTHESIS 11 8.42e-01 0.034700 9.19e-01
TELOMERE EXTENSION BY TELOMERASE 22 7.79e-01 0.034500 8.91e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 280 3.23e-01 0.034400 5.64e-01
ACYL CHAIN REMODELLING OF PG 10 8.51e-01 -0.034300 9.22e-01
HOMOLOGY DIRECTED REPAIR 107 5.41e-01 -0.034300 7.40e-01
EPHB MEDIATED FORWARD SIGNALING 42 7.02e-01 -0.034100 8.42e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 20 7.92e-01 -0.034100 8.98e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 41 7.06e-01 0.034000 8.44e-01
RHO GTPASES ACTIVATE IQGAPS 23 7.81e-01 -0.033400 8.91e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 7.37e-01 -0.033200 8.60e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 88 5.95e-01 -0.032800 7.71e-01
CELL CELL JUNCTION ORGANIZATION 50 6.88e-01 -0.032800 8.32e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 8.15e-01 -0.032800 9.05e-01
MAPK FAMILY SIGNALING CASCADES 286 3.42e-01 0.032700 5.85e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 6.99e-01 0.032600 8.40e-01
RHO GTPASE EFFECTORS 245 3.86e-01 -0.032200 6.32e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 6.23e-01 0.032200 7.95e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 7.41e-01 -0.031900 8.61e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 6.49e-01 -0.031700 8.11e-01
SPHINGOLIPID METABOLISM 80 6.26e-01 -0.031500 7.95e-01
SUMOYLATION 161 4.91e-01 0.031500 7.07e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 8.66e-01 -0.030900 9.29e-01
AURKA ACTIVATION BY TPX2 71 6.54e-01 0.030800 8.12e-01
CLATHRIN MEDIATED ENDOCYTOSIS 130 5.50e-01 0.030400 7.40e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 8.14e-01 0.030300 9.05e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 364 3.22e-01 0.030300 5.63e-01
RHOD GTPASE CYCLE 50 7.12e-01 0.030200 8.45e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 8.63e-01 -0.030000 9.29e-01
SIGNALING BY ERBB2 47 7.26e-01 -0.029500 8.52e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 8.40e-01 -0.029200 9.18e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 8.73e-01 -0.029200 9.32e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 8.56e-01 0.029200 9.24e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 8.01e-01 0.029100 9.00e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 6.30e-01 0.028900 7.96e-01
SYNDECAN INTERACTIONS 26 8.02e-01 -0.028400 9.00e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 4.68e-01 -0.028200 6.95e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 7.08e-01 0.028200 8.45e-01
NGF STIMULATED TRANSCRIPTION 37 7.67e-01 -0.028100 8.81e-01
SIGNALING BY ERBB2 IN CANCER 24 8.12e-01 -0.028100 9.05e-01
SIGNALING BY PDGFR IN DISEASE 20 8.30e-01 -0.027700 9.12e-01
GLYCOSPHINGOLIPID METABOLISM 39 7.65e-01 -0.027700 8.80e-01
METABOLISM OF PORPHYRINS 19 8.36e-01 0.027500 9.16e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 8.20e-01 0.027400 9.08e-01
DOWNREGULATION OF ERBB2 SIGNALING 27 8.06e-01 0.027300 9.02e-01
CELLULAR RESPONSE TO HEAT STRESS 94 6.49e-01 -0.027200 8.11e-01
TIGHT JUNCTION INTERACTIONS 19 8.38e-01 0.027200 9.18e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 8.67e-01 0.026900 9.29e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 6.63e-01 0.026900 8.18e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 7.39e-01 -0.026700 8.61e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 8.55e-01 0.026400 9.24e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 7.82e-01 -0.026300 8.91e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 6.56e-01 -0.025600 8.12e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 35 7.99e-01 0.024900 9.00e-01
METABOLISM OF VITAMINS AND COFACTORS 151 5.98e-01 0.024900 7.73e-01
G1 S SPECIFIC TRANSCRIPTION 26 8.28e-01 0.024600 9.12e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 7.49e-01 -0.024500 8.67e-01
CELL JUNCTION ORGANIZATION 74 7.22e-01 0.023900 8.52e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 8.27e-01 0.023900 9.12e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 8.91e-01 -0.023900 9.39e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 22 8.46e-01 -0.023900 9.20e-01
VXPX CARGO TARGETING TO CILIUM 19 8.58e-01 0.023700 9.26e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 8.14e-01 -0.023700 9.05e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.74e-01 -0.023600 9.32e-01
TRANSCRIPTIONAL REGULATION BY TP53 342 4.58e-01 -0.023400 6.88e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 16 8.72e-01 0.023300 9.32e-01
NEUROTRANSMITTER RELEASE CYCLE 47 7.82e-01 0.023300 8.91e-01
SIGNALING BY NOTCH 189 5.82e-01 0.023300 7.64e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 8.49e-01 -0.022900 9.21e-01
P38MAPK EVENTS 12 8.92e-01 0.022600 9.39e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 8.03e-01 0.022300 9.00e-01
MITOCHONDRIAL BIOGENESIS 92 7.12e-01 -0.022300 8.45e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 8.31e-01 0.022100 9.12e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 8.84e-01 -0.021700 9.39e-01
NERVOUS SYSTEM DEVELOPMENT 547 4.00e-01 -0.021100 6.40e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 8.45e-01 -0.021000 9.20e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 9.09e-01 -0.020800 9.50e-01
DEVELOPMENTAL BIOLOGY 814 3.17e-01 0.020800 5.59e-01
GPVI MEDIATED ACTIVATION CASCADE 31 8.46e-01 -0.020200 9.20e-01
INTERLEUKIN 35 SIGNALLING 10 9.12e-01 0.020100 9.50e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1213 2.47e-01 -0.019900 4.90e-01
EPH EPHRIN SIGNALING 92 7.42e-01 0.019800 8.61e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 282 5.67e-01 0.019800 7.51e-01
POTENTIAL THERAPEUTICS FOR SARS 77 7.66e-01 -0.019600 8.80e-01
AMYLOID FIBER FORMATION 57 7.98e-01 -0.019600 9.00e-01
TOLL LIKE RECEPTOR CASCADES 137 6.93e-01 -0.019600 8.36e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.11e-01 0.019400 9.50e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 8.78e-01 -0.019400 9.35e-01
MEMBRANE TRAFFICKING 576 4.28e-01 0.019400 6.61e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 9.04e-01 0.019300 9.48e-01
PLASMA LIPOPROTEIN CLEARANCE 27 8.65e-01 -0.018900 9.29e-01
HCMV LATE EVENTS 65 7.93e-01 0.018800 8.98e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 8.66e-01 0.018700 9.29e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 8.88e-01 0.018600 9.39e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 8.31e-01 -0.018600 9.12e-01
RHOF GTPASE CYCLE 40 8.39e-01 0.018600 9.18e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 6.65e-01 0.018500 8.18e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 9.02e-01 0.018500 9.46e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 7.56e-01 -0.018300 8.72e-01
SIGNAL TRANSDUCTION BY L1 21 8.87e-01 0.017900 9.39e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 7.94e-01 0.017600 8.98e-01
CA2 PATHWAY 56 8.20e-01 -0.017600 9.08e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 8.47e-01 0.017400 9.20e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 7.98e-01 -0.017200 9.00e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 9.12e-01 -0.017000 9.50e-01
SIGNALING BY NTRK2 TRKB 24 8.86e-01 0.016900 9.39e-01
SPRY REGULATION OF FGF SIGNALING 16 9.08e-01 0.016700 9.50e-01
DNA METHYLATION 20 8.98e-01 -0.016500 9.43e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 8.19e-01 -0.016500 9.08e-01
SIGNALING BY FGFR1 IN DISEASE 32 8.72e-01 -0.016400 9.32e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 8.29e-01 0.016200 9.12e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 8.83e-01 -0.016100 9.38e-01
G ALPHA I SIGNALLING EVENTS 189 7.04e-01 -0.016000 8.44e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 29 8.82e-01 -0.016000 9.38e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 9.16e-01 -0.015700 9.52e-01
SIGNALING BY FGFR3 35 8.72e-01 -0.015700 9.32e-01
ACYL CHAIN REMODELLING OF PE 16 9.16e-01 -0.015300 9.52e-01
DISEASES OF DNA REPAIR 11 9.30e-01 -0.015200 9.61e-01
METABOLISM OF LIPIDS 610 5.24e-01 0.015200 7.31e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 90 8.04e-01 -0.015100 9.00e-01
HDR THROUGH MMEJ ALT NHEJ 10 9.35e-01 0.014900 9.64e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 8.97e-01 0.014700 9.43e-01
LEISHMANIA INFECTION 190 7.28e-01 0.014700 8.53e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 8.42e-01 -0.014600 9.19e-01
ASPARAGINE N LINKED GLYCOSYLATION 282 6.75e-01 -0.014500 8.26e-01
HIV ELONGATION ARREST AND RECOVERY 32 8.90e-01 0.014100 9.39e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 57 8.55e-01 -0.014000 9.24e-01
IRAK1 RECRUITS IKK COMPLEX 14 9.28e-01 0.013900 9.61e-01
FLT3 SIGNALING 37 8.87e-01 -0.013500 9.39e-01
METAL ION SLC TRANSPORTERS 25 9.08e-01 0.013400 9.50e-01
SURFACTANT METABOLISM 17 9.24e-01 0.013400 9.57e-01
HEMOSTASIS 474 6.24e-01 0.013200 7.95e-01
VESICLE MEDIATED TRANSPORT 604 5.87e-01 0.013000 7.66e-01
MEIOTIC SYNAPSIS 39 8.92e-01 -0.012600 9.39e-01
RHOJ GTPASE CYCLE 54 8.74e-01 -0.012500 9.32e-01
OPIOID SIGNALLING 86 8.49e-01 -0.011900 9.21e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 8.62e-01 -0.011900 9.29e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 9.21e-01 -0.011200 9.55e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 8.45e-01 0.011200 9.20e-01
LYSINE CATABOLISM 11 9.49e-01 0.011100 9.69e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 9.46e-01 0.010900 9.69e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 9.48e-01 0.010500 9.69e-01
TRANSPORT OF SMALL MOLECULES 574 6.87e-01 0.009890 8.32e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 164 8.29e-01 -0.009810 9.12e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 9.55e-01 0.009360 9.74e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 9.47e-01 0.009100 9.69e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 9.20e-01 -0.008970 9.55e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 9.40e-01 0.008940 9.67e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 9.29e-01 -0.008570 9.61e-01
SIGNALING BY HEDGEHOG 142 8.63e-01 -0.008410 9.29e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 9.33e-01 -0.008360 9.62e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 110 8.80e-01 0.008310 9.37e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.49e-01 -0.008050 9.69e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 9.45e-01 0.007880 9.69e-01
UNWINDING OF DNA 12 9.62e-01 0.007870 9.79e-01
OTHER INTERLEUKIN SIGNALING 19 9.57e-01 0.007120 9.75e-01
SENSORY PERCEPTION 148 8.86e-01 0.006850 9.39e-01
IRS MEDIATED SIGNALLING 37 9.43e-01 -0.006780 9.69e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 9.36e-01 -0.006750 9.64e-01
MITOTIC PROPHASE 94 9.11e-01 -0.006650 9.50e-01
PYRIMIDINE SALVAGE 10 9.74e-01 0.005990 9.86e-01
SNRNP ASSEMBLY 51 9.41e-01 -0.005950 9.68e-01
CGMP EFFECTS 15 9.70e-01 -0.005680 9.83e-01
DNA DOUBLE STRAND BREAK REPAIR 136 9.11e-01 -0.005570 9.50e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.31e-01 -0.005440 9.61e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 9.79e-01 0.004920 9.88e-01
GPCR LIGAND BINDING 244 8.98e-01 -0.004780 9.43e-01
DISEASES OF IMMUNE SYSTEM 23 9.70e-01 0.004590 9.83e-01
RAP1 SIGNALLING 15 9.76e-01 -0.004570 9.86e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 9.68e-01 0.004090 9.83e-01
VISUAL PHOTOTRANSDUCTION 60 9.57e-01 0.003980 9.75e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 9.83e-01 0.003840 9.90e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 179 9.48e-01 -0.002820 9.69e-01
INTRAFLAGELLAR TRANSPORT 50 9.73e-01 -0.002790 9.85e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.84e-01 -0.002380 9.90e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 9.89e-01 -0.002130 9.94e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 9.85e-01 -0.002010 9.90e-01
GOLGI TO ER RETROGRADE TRANSPORT 119 9.75e-01 0.001650 9.86e-01
CS DS DEGRADATION 14 9.93e-01 0.001400 9.94e-01
DNA REPAIR 292 9.68e-01 -0.001370 9.83e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 25 9.91e-01 0.001260 9.94e-01
TRNA PROCESSING 105 9.82e-01 0.001240 9.90e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 9.93e-01 -0.001230 9.94e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 9.96e-01 0.000782 9.96e-01
G ALPHA Q SIGNALLING EVENTS 146 9.89e-01 0.000650 9.94e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 9.96e-01 0.000530 9.96e-01


Detailed Gene set reports



SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
set SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize 12
pANOVA 8.7e-05
s.dist -0.654
p.adjustANOVA 0.000958


Top enriched genes
Top 20 genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7836
Spcs3 -7741
Spcs1 -6628
Pcsk1 -6432
Sec11a -6396
Sec11c -5205
Grp -4621
Tcf7l2 -3843
Pax6 -3358
Ctnnb1 -2569
Gng13 -2173

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7836
Spcs3 -7741
Spcs1 -6628
Pcsk1 -6432
Sec11a -6396
Sec11c -5205
Grp -4621
Tcf7l2 -3843
Pax6 -3358
Ctnnb1 -2569
Gng13 -2173


INCRETIN SYNTHESIS SECRETION AND INACTIVATION
set INCRETIN SYNTHESIS SECRETION AND INACTIVATION
setSize 13
pANOVA 5.24e-05
s.dist -0.648
p.adjustANOVA 0.00062


Top enriched genes
Top 20 genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7836
Spcs3 -7741
Spcs1 -6628
Pcsk1 -6432
Sec11a -6396
Sec11c -5205
Isl1 -4717
Grp -4621
Tcf7l2 -3843
Pax6 -3358
Ctnnb1 -2569
Gng13 -2173

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7836
Spcs3 -7741
Spcs1 -6628
Pcsk1 -6432
Sec11a -6396
Sec11c -5205
Isl1 -4717
Grp -4621
Tcf7l2 -3843
Pax6 -3358
Ctnnb1 -2569
Gng13 -2173


EUKARYOTIC TRANSLATION ELONGATION
set EUKARYOTIC TRANSLATION ELONGATION
setSize 87
pANOVA 1.82e-20
s.dist -0.575
p.adjustANOVA 4.26e-18


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8142
Rplp0 -8067
Rpl5 -8041
Rpl27a -7808
Rps2 -7770
Eef1g -7649
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Rps3a1 -7249
Rpl15 -7147
Rps4x -7103
Rpl6 -6989
Eef1b2 -6802

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8142
Rplp0 -8067
Rpl5 -8041
Rpl27a -7808
Rps2 -7770
Eef1g -7649
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Rps3a1 -7249
Rpl15 -7147
Rps4x -7103
Rpl6 -6989
Eef1b2 -6802
Rps6 -6780
Rpl9 -6766
Rpl24 -6733
Rps3 -6621
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Rpl11 -6317
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Rps13 -6052
Rps27l -5977
Eef1a1 -5774
Rps25 -5719
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Rps9 -5360
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Rps19 -4739
Rpsa -4553
Rps11 -4521
Rpl7a -4364
Rps10 -4316
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Rps15a -3371
Fau -3268
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Eef1d -1550
Rps21 -1427
Eef1a2 -1005
Eef2 -752
Rplp2 -430
Rpl36 -165
Rpl37 145
Rpl10 514
Rpl12 952
Rpl38 1303
Rps28 2426
Rps29 4009


GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
set GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
setSize 31
pANOVA 8.83e-08
s.dist -0.555
p.adjustANOVA 2.53e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8067
Hnrnpdl -7926
Rap1b -7873
Ppia -7847
Hspa9 -7464
Rala -7437
Hnrnpa2b1 -7380
Pdcd4 -6990
Mtap -6820
Psme2 -6586
Lcp1 -5848
Capza1 -5797
Gsto1 -5547
Snrpa1 -5226
Cnn2 -5023
Pak2 -5001
Hnrnpf -4674
Taldo1 -3814

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8067
Hnrnpdl -7926
Rap1b -7873
Ppia -7847
Hspa9 -7464
Rala -7437
Hnrnpa2b1 -7380
Pdcd4 -6990
Mtap -6820
Psme2 -6586
Lcp1 -5848
Capza1 -5797
Gsto1 -5547
Snrpa1 -5226
Cnn2 -5023
Pak2 -5001
Hnrnpf -4674
Taldo1 -3814
Sod2 -3756
Sod1 -3216
Cfl1 -3018
Aip -2618
Pitpna -1698
Msn -1261
Arf1 -565
Bola2 -8
Anxa2 509
Lmnb1 1474
Mif 4010


ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
set ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
setSize 59
pANOVA 1.91e-13
s.dist -0.553
p.adjustANOVA 1.24e-11


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Eif2s2 -8324
Eif4a2 -8274
Eif3j2 -8207
Eif3e -8203
Eif4e -8157
Eif2s1 -8080
Eif3m -8004
Rps2 -7770
Rps24 -7593
Pabpc1 -7329
Rps3a1 -7249
Eif3h -7128
Rps4x -7103
Rps6 -6780
Eif1ax -6716
Eif2s3x -6650
Rps3 -6621
Rps8 -6584

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Eif2s2 -8324
Eif4a2 -8274
Eif3j2 -8207
Eif3e -8203
Eif4e -8157
Eif2s1 -8080
Eif3m -8004
Rps2 -7770
Rps24 -7593
Pabpc1 -7329
Rps3a1 -7249
Eif3h -7128
Rps4x -7103
Rps6 -6780
Eif1ax -6716
Eif2s3x -6650
Rps3 -6621
Rps8 -6584
Rps23 -6543
Rps27a -6498
Rps14 -6143
Rps13 -6052
Eif3a -6013
Rps27l -5977
Eif4b -5757
Rps25 -5719
Rps9 -5360
Eif3g -5315
Rps16 -5186
Rps20 -5082
Rps19 -4739
Rpsa -4553
Rps11 -4521
Rps10 -4316
Eif4a1 -4208
Eif3j1 -4147
Rps26 -3866
Rps17 -3849
Rps27 -3640
Rps15a -3371
Eif4ebp1 -3363
Fau -3268
Rps5 -3041
Eif3c -2718
Eif3k -2431
Eif3d -2344
Rps15 -2201
Rps12 -1815
Eif3f -1745
Rps21 -1427
Eif3i 285
Eif4h 1597
Eif3l 2393
Rps28 2426
Eif3b 3056
Eif4g1 3973
Rps29 4009


EUKARYOTIC TRANSLATION INITIATION
set EUKARYOTIC TRANSLATION INITIATION
setSize 114
pANOVA 3.54e-24
s.dist -0.55
p.adjustANOVA 2.07e-21


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Eif5b -8297
Rpl30 -8293
Eif4a2 -8274
Eif5 -8214
Eif3j2 -8207
Eif3e -8203
Eif4e -8157
Rpl22l1 -8142
Eif2s1 -8080
Rplp0 -8067
Rpl5 -8041
Eif3m -8004
Rpl27a -7808
Rps2 -7770
Rpl36a -7626
Rps24 -7593

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Eif5b -8297
Rpl30 -8293
Eif4a2 -8274
Eif5 -8214
Eif3j2 -8207
Eif3e -8203
Eif4e -8157
Rpl22l1 -8142
Eif2s1 -8080
Rplp0 -8067
Rpl5 -8041
Eif3m -8004
Rpl27a -7808
Rps2 -7770
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Pabpc1 -7329
Rps3a1 -7249
Rpl15 -7147
Eif3h -7128
Rps4x -7103
Rpl6 -6989
Eif2b3 -6847
Rps6 -6780
Rpl9 -6766
Rpl24 -6733
Eif1ax -6716
Eif2s3x -6650
Rps3 -6621
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Rpl11 -6317
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Rps13 -6052
Eif3a -6013
Rps27l -5977
Eif4b -5757
Rps25 -5719
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Rps9 -5360
Eif3g -5315
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Rps19 -4739
Rpsa -4553
Rps11 -4521
Rpl7a -4364
Rps10 -4316
Eif4a1 -4208
Eif3j1 -4147
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Rps15a -3371
Eif4ebp1 -3363
Fau -3268
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Eif3c -2718
Rplp1 -2691
Rpl8 -2622
Eif2b5 -2578
Eif3k -2431
Eif3d -2344
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Eif3f -1745
Rps21 -1427
Rplp2 -430
Rpl36 -165
Rpl37 145
Eif3i 285
Rpl10 514
Rpl12 952
Rpl38 1303
Eif4h 1597
Eif2b4 2123
Eif3l 2393
Rps28 2426
Eif2b1 2552
Eif3b 3056
Eif4g1 3973
Rps29 4009
Eif2b2 6856


SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
set SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize 106
pANOVA 4.7e-22
s.dist -0.542
p.adjustANOVA 1.43e-19


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Spcs2 -8284
Rpl22l1 -8142
Rplp0 -8067
Rpl5 -8041
Srp54a -7881
Rpl27a -7808
Rps2 -7770
Spcs3 -7741
Rpl36a -7626
Srp19 -7608
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Ssr3 -7315
Rps3a1 -7249

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Spcs2 -8284
Rpl22l1 -8142
Rplp0 -8067
Rpl5 -8041
Srp54a -7881
Rpl27a -7808
Rps2 -7770
Spcs3 -7741
Rpl36a -7626
Srp19 -7608
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Ssr3 -7315
Rps3a1 -7249
Ssr1 -7169
Rpl15 -7147
Rps4x -7103
Rpl6 -6989
Rps6 -6780
Rpl9 -6766
Sec61g -6749
Rpl24 -6733
Srp14 -6721
Spcs1 -6628
Rps3 -6621
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Sec11a -6396
Rpl11 -6317
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Srp9 -6065
Rps13 -6052
Rps27l -5977
Rps25 -5719
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Rps9 -5360
Sec11c -5205
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Rps19 -4739
Rpsa -4553
Rps11 -4521
Rpl7a -4364
Rps10 -4316
Rpn1 -4193
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Rps15a -3371
Fau -3268
Tram1 -3223
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Sec61b -2933
Rpl39 -2737
Srp72 -2721
Ssr4 -2693
Rplp1 -2691
Rpl8 -2622
Ssr2 -2440
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Rps21 -1427
Rplp2 -430
Rpn2 -246
Rpl36 -165
Srprb 131
Rpl37 145
Ddost 192
Rpl10 514
Rpl12 952
Rpl38 1303
Sec61a2 1782
Rps28 2426
Srpr 2712
Rps29 4009
Srp68 6075
Sec61a1 7340


RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
set RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize 94
pANOVA 2.26e-19
s.dist -0.537
p.adjustANOVA 3.78e-17


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Rpl30 -8293
Rpl22l1 -8142
Eif2s1 -8080
Rplp0 -8067
Rpl5 -8041
Rpl27a -7808
Cebpg -7784
Rps2 -7770
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Rps3a1 -7249
Rpl15 -7147
Rps4x -7103

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Rpl30 -8293
Rpl22l1 -8142
Eif2s1 -8080
Rplp0 -8067
Rpl5 -8041
Rpl27a -7808
Cebpg -7784
Rps2 -7770
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Rps3a1 -7249
Rpl15 -7147
Rps4x -7103
Rpl6 -6989
Rps6 -6780
Rpl9 -6766
Rpl24 -6733
Eif2s3x -6650
Rps3 -6621
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Asns -6353
Rpl11 -6317
Impact -6273
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Rps13 -6052
Rps27l -5977
Rps25 -5719
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Atf2 -5439
Rps9 -5360
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Rps19 -4739
Rpsa -4553
Rps11 -4521
Rpl7a -4364
Rps10 -4316
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Rps15a -3371
Fau -3268
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Rps21 -1427
Atf3 -1057
Rplp2 -430
Atf4 -353
Rpl36 -165
Rpl37 145
Ddit3 207
Rpl10 514
Rpl12 952
Rpl38 1303
Rps28 2426
Rps29 4009
Cebpb 6859
Eif2ak4 8310
Gcn1 8500


SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
set SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
setSize 12
pANOVA 0.00155
s.dist -0.528
p.adjustANOVA 0.0119


Top enriched genes
Top 20 genes
GeneID Gene Rank
Spcs2 -8284
Pla2g7 -8193
Spcs3 -7741
Spcs1 -6628
Pcsk1 -6432
Sec11a -6396
Bche -5752
Sec11c -5205
Igf1 -3522
Klf4 -2316
Crhr2 3749
Ache 4466

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8284
Pla2g7 -8193
Spcs3 -7741
Spcs1 -6628
Pcsk1 -6432
Sec11a -6396
Bche -5752
Sec11c -5205
Igf1 -3522
Klf4 -2316
Crhr2 3749
Ache 4466


ADENYLATE CYCLASE ACTIVATING PATHWAY
set ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize 10
pANOVA 0.00489
s.dist 0.514
p.adjustANOVA 0.0301


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adcy6 8344
Adcy1 7877
Adcy4 7560
Adcy3 6273
Adcy5 6106
Adcy9 6007
Adcy7 5771
Gnal 1961
Adcy2 -1367
Adcy8 -3915

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8344
Adcy1 7877
Adcy4 7560
Adcy3 6273
Adcy5 6106
Adcy9 6007
Adcy7 5771
Gnal 1961
Adcy2 -1367
Adcy8 -3915


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 3.39e-06
s.dist -0.498
p.adjustANOVA 5.83e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ube2b -8168
Ube2d2a -8124
Ube2l3 -8108
Ube2d1 -8101
Ube2e1 -8075
Ube2k -7796
Ube2a -7640
Ube2w -7491
Ube2e3 -7473
Ube2r2 -7386
Ube2t -7151
Ube2g1 -7109
Ube2q2 -6667
Rps27a -6498
Uchl3 -6207
Uba52 -3962
Otulin -3807
Ube2s -3360
Uba6 -2871
Usp9x -2098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2b -8168
Ube2d2a -8124
Ube2l3 -8108
Ube2d1 -8101
Ube2e1 -8075
Ube2k -7796
Ube2a -7640
Ube2w -7491
Ube2e3 -7473
Ube2r2 -7386
Ube2t -7151
Ube2g1 -7109
Ube2q2 -6667
Rps27a -6498
Uchl3 -6207
Uba52 -3962
Otulin -3807
Ube2s -3360
Uba6 -2871
Usp9x -2098
Ubb -1705
Cdc34 -1533
Usp7 -414
Ubc 176
Ube2z 994
Ube2h 1795
Usp5 1844
Uba1 2296
Ube2g2 5696


COMPLEX I BIOGENESIS
set COMPLEX I BIOGENESIS
setSize 56
pANOVA 1.48e-10
s.dist -0.495
p.adjustANOVA 8.26e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
Ndufaf2 -8037
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
mt-Nd2 -7693
Ndufa10 -7692
Ndufb4 -7618
Ndufaf1 -7517
mt-Nd4 -7350
Ndufaf5 -7173
Ndufb5 -7051
mt-Nd6 -7048
Ndufb6 -6775
mt-Nd5 -6714
Ndufc1 -6492
Nubpl -6403
Ndufa8 -6291

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
Ndufaf2 -8037
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
mt-Nd2 -7693
Ndufa10 -7692
Ndufb4 -7618
Ndufaf1 -7517
mt-Nd4 -7350
Ndufaf5 -7173
Ndufb5 -7051
mt-Nd6 -7048
Ndufb6 -6775
mt-Nd5 -6714
Ndufc1 -6492
Nubpl -6403
Ndufa8 -6291
Ndufa9 -6261
Ndufs2 -6095
Ndufb3 -6049
Ndufb9 -5884
Ndufa12 -5880
Ndufa5 -5748
Ndufs5 -5273
Ndufb2 -5054
Ndufs6 -5005
Ndufs1 -4860
Ndufb11 -4705
Ndufb8 -4576
Tmem126b -4551
Ndufaf6 -4411
Ndufa6 -3971
Ndufs8 -3712
Ndufs3 -3558
Ndufaf7 -2652
Ndufv1 -2446
Ndufa1 -2342
Ndufb1 -1848
Timmdc1 -1652
Ndufab1 -1622
Ndufaf3 -1006
Ndufa7 -922
Ndufb7 -678
Ndufa13 -112
Ndufb10 93
Ndufa2 115
Ndufa11 762
Ndufv3 1317
Acad9 1433
Ndufs7 2962
Ndufa3 3435
Ecsit 5458
Tmem186 5509


CD28 DEPENDENT VAV1 PATHWAY
set CD28 DEPENDENT VAV1 PATHWAY
setSize 11
pANOVA 0.00493
s.dist -0.49
p.adjustANOVA 0.0303


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cdc42 -8238
Pak1 -8117
Pak3 -6856
Rac1 -5805
Cd86 -5014
Pak2 -5001
Cd80 -2882
Grb2 -2784
Lck -1794
Fyn 1002
Vav1 1150

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc42 -8238
Pak1 -8117
Pak3 -6856
Rac1 -5805
Cd86 -5014
Pak2 -5001
Cd80 -2882
Grb2 -2784
Lck -1794
Fyn 1002
Vav1 1150


CRMPS IN SEMA3A SIGNALING
set CRMPS IN SEMA3A SIGNALING
setSize 16
pANOVA 0.000716
s.dist 0.489
p.adjustANOVA 0.0063


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dpysl5 8432
Plxna1 8243
Plxna3 7929
Dpysl4 7607
Fes 7247
Plxna2 6987
Plxna4 6957
Crmp1 6153
Nrp1 6033
Dpysl2 2872
Cdk5 2573
Fyn 1002
Gsk3b -138
Cdk5r1 -305
Dpysl3 -1629
Sema3a -2039

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dpysl5 8432
Plxna1 8243
Plxna3 7929
Dpysl4 7607
Fes 7247
Plxna2 6987
Plxna4 6957
Crmp1 6153
Nrp1 6033
Dpysl2 2872
Cdk5 2573
Fyn 1002
Gsk3b -138
Cdk5r1 -305
Dpysl3 -1629
Sema3a -2039


SELENOAMINO ACID METABOLISM
set SELENOAMINO ACID METABOLISM
setSize 109
pANOVA 2.8e-18
s.dist -0.483
p.adjustANOVA 3.64e-16


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8142
Hnmt -8091
Rplp0 -8067
Rpl5 -8041
Rpl27a -7808
Rps2 -7770
Rars -7669
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Ahcy -7589
Aimp1 -7571
Rpl26 -7530
Dars -7466
Rpl3 -7425

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8142
Hnmt -8091
Rplp0 -8067
Rpl5 -8041
Rpl27a -7808
Rps2 -7770
Rars -7669
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Ahcy -7589
Aimp1 -7571
Rpl26 -7530
Dars -7466
Rpl3 -7425
Rps3a1 -7249
Sars -7191
Rpl15 -7147
Rps4x -7103
Rpl6 -6989
Rps6 -6780
Rpl9 -6766
Rpl24 -6733
Rps3 -6621
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Rpl11 -6317
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Rps13 -6052
Rps27l -5977
Rps25 -5719
Pstk -5615
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Rps9 -5360
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Eprs -5047
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Papss2 -4780
Rps19 -4739
Sephs2 -4676
Rpsa -4553
Rps11 -4521
Rpl7a -4364
Rps10 -4316
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Kars -3399
Rps15a -3371
Fau -3268
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Papss1 -2803
Rpl39 -2737
Rplp1 -2691
Gsr -2684
Rpl8 -2622
Cbs -2611
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Rps21 -1427
Lars -1221
Aimp2 -462
Inmt -457
Rplp2 -430
Rpl36 -165
Rpl37 145
Rpl10 514
Rpl12 952
Eefsec 1273
Rpl38 1303
Scly 1990
Sepsecs 2324
Rps28 2426
Cth 2457
Txnrd1 3667
Rps29 4009
Iars 5548
Gnmt 6062
Qars 6328
Mars1 6723
Secisbp2 8326


APOPTOSIS INDUCED DNA FRAGMENTATION
set APOPTOSIS INDUCED DNA FRAGMENTATION
setSize 10
pANOVA 0.00903
s.dist -0.477
p.adjustANOVA 0.0487


Top enriched genes
Top 20 genes
GeneID Gene Rank
H1f2 -8340
Casp3 -8259
Hmgb1 -8226
H1f0 -8176
Hmgb2 -7880
H1f4 -5809
Kpna1 -5450
Kpnb1 1223
Dffb 5690
Dffa 5992

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H1f2 -8340
Casp3 -8259
Hmgb1 -8226
H1f0 -8176
Hmgb2 -7880
H1f4 -5809
Kpna1 -5450
Kpnb1 1223
Dffb 5690
Dffa 5992


PROTEIN METHYLATION
set PROTEIN METHYLATION
setSize 17
pANOVA 0.000784
s.dist -0.47
p.adjustANOVA 0.0068


Top enriched genes
Top 20 genes
GeneID Gene Rank
Calm1 -8268
Hspa8 -7921
Rps2 -7770
Eef1akmt2 -7277
Kin -7230
Vcpkmt -7227
Vcp -6373
Eef1a1 -5774
Etfb -5390
Etfbkmt -5262
Eef1akmt1 -4745
Camkmt -2777
Mettl21a -1900
Eef2 -752
Eef2kmt 2340
Prmt3 5168
Mettl22 5401

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calm1 -8268
Hspa8 -7921
Rps2 -7770
Eef1akmt2 -7277
Kin -7230
Vcpkmt -7227
Vcp -6373
Eef1a1 -5774
Etfb -5390
Etfbkmt -5262
Eef1akmt1 -4745
Camkmt -2777
Mettl21a -1900
Eef2 -752
Eef2kmt 2340
Prmt3 5168
Mettl22 5401


TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
set TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize 11
pANOVA 0.00839
s.dist -0.459
p.adjustANOVA 0.0463


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hsp90b1 -8325
Tlr3 -8233
Ctsl -7966
Ctss -7945
Ctsb -6539
Lgmn -5800
Tlr7 -1935
Ctsk -1464
Cnpy3 1853
Tlr9 2360
Unc93b1 2494

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsp90b1 -8325
Tlr3 -8233
Ctsl -7966
Ctss -7945
Ctsb -6539
Lgmn -5800
Tlr7 -1935
Ctsk -1464
Cnpy3 1853
Tlr9 2360
Unc93b1 2494


RESPIRATORY ELECTRON TRANSPORT
set RESPIRATORY ELECTRON TRANSPORT
setSize 102
pANOVA 1.32e-15
s.dist -0.458
p.adjustANOVA 1.19e-13


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
mt-Co1 -8118
Ndufaf2 -8037
Uqcrc2 -7976
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
mt-Nd2 -7693
Ndufa10 -7692
Cox20 -7657
Ndufb4 -7618
Ndufaf1 -7517
Cox7a2l -7372
Etfa -7358
mt-Nd4 -7350
mt-Co2 -7287
mt-Cytb -7190

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
mt-Co1 -8118
Ndufaf2 -8037
Uqcrc2 -7976
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
mt-Nd2 -7693
Ndufa10 -7692
Cox20 -7657
Ndufb4 -7618
Ndufaf1 -7517
Cox7a2l -7372
Etfa -7358
mt-Nd4 -7350
mt-Co2 -7287
mt-Cytb -7190
Ndufaf5 -7173
Sco1 -7114
Ndufb5 -7051
mt-Nd6 -7048
mt-Co3 -7030
Cox7b -6992
Ndufb6 -6775
Ndufa4 -6746
Coq10b -6739
mt-Nd5 -6714
Ndufc1 -6492
Nubpl -6403
Ndufa8 -6291
Ndufa9 -6261
Cox16 -6209
Uqcrb -6107
Ndufs2 -6095
Ndufb3 -6049
Sdhc -5907
Ndufb9 -5884
Ndufa12 -5880
Ndufa5 -5748
Cox6c -5704
Etfb -5390
Ndufs5 -5273
Ndufb2 -5054
Ndufs6 -5005
Sdhd -4866
Ndufs1 -4860
Etfdh -4831
Ndufb11 -4705
Ndufb8 -4576
Surf1 -4554
Tmem126b -4551
Uqcrh -4434
Ndufaf6 -4411
Cox5a -4307
Cox7c -4255
Sdha -4024
Cox4i1 -3973
Ndufa6 -3971
Ndufs8 -3712
Ndufs3 -3558
Sdhb -3436
Sco2 -3312
Uqcrq -2949
Ndufaf7 -2652
Ndufv1 -2446
Cox14 -2445
Ndufa1 -2342
Ndufb1 -1848
Cox19 -1734
Timmdc1 -1652
Ndufab1 -1622
Cox6b1 -1294
Lrpprc -1274
Cox6a1 -1024
Ndufaf3 -1006
Ndufa7 -922
Uqcrfs1 -898
Ndufb7 -678
Uqcr10 -621
Ndufa13 -112
Ndufb10 93
Ndufa2 115
Cox5b 523
Coq10a 573
Cox8a 689
Ndufa11 762
Cyc1 766
Uqcr11 1037
Cox11 1133
Ndufv3 1317
Acad9 1433
Uqcrc1 1967
Ndufs7 2962
Ndufa3 3435
Ecsit 5458
Tmem186 5509
Cox18 6029
Taco1 6078
Trap1 6578


TERMINATION OF O GLYCAN BIOSYNTHESIS
set TERMINATION OF O GLYCAN BIOSYNTHESIS
setSize 10
pANOVA 0.0125
s.dist 0.456
p.adjustANOVA 0.0637


Top enriched genes
Top 20 genes
GeneID Gene Rank
St3gal3 7970
St3gal1 7174
St3gal2 5162
Muc3a 5147
St6galnac2 5050
St6galnac4 5025
St6galnac3 3410
Muc6 2070
St3gal4 -443
St6gal1 -847

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All member genes
GeneID Gene Rank
St3gal3 7970
St3gal1 7174
St3gal2 5162
Muc3a 5147
St6galnac2 5050
St6galnac4 5025
St6galnac3 3410
Muc6 2070
St3gal4 -443
St6gal1 -847


ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
set ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize 19
pANOVA 0.000592
s.dist -0.455
p.adjustANOVA 0.00529


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gng11 -8252
P2ry12 -7453
Gng10 -7222
Gnai3 -7221
Gng12 -7195
Gnai1 -6307
Gnb4 -5410
Gngt2 -5364
Gnb1 -5116
Gng5 -4385
Gng2 -4120
Gng3 -4034
Gng4 -2468
Gng13 -2173
Gnb5 -454
Gnai2 478
Gng8 918
Gnb2 2173
Gng7 2569

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng11 -8252
P2ry12 -7453
Gng10 -7222
Gnai3 -7221
Gng12 -7195
Gnai1 -6307
Gnb4 -5410
Gngt2 -5364
Gnb1 -5116
Gng5 -4385
Gng2 -4120
Gng3 -4034
Gng4 -2468
Gng13 -2173
Gnb5 -454
Gnai2 478
Gng8 918
Gnb2 2173
Gng7 2569


REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
set REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
setSize 10
pANOVA 0.0137
s.dist 0.45
p.adjustANOVA 0.0681


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slit1 8422
Src 8037
Slit3 7065
Nell2 5340
Robo1 4330
Robo3 3270
Ntn1 3117
Dcc 2131
Robo2 1899
Slit2 -4404

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slit1 8422
Src 8037
Slit3 7065
Nell2 5340
Robo1 4330
Robo3 3270
Ntn1 3117
Dcc 2131
Robo2 1899
Slit2 -4404


SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
set SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
setSize 14
pANOVA 0.00377
s.dist 0.447
p.adjustANOVA 0.0248


Top enriched genes
Top 20 genes
GeneID Gene Rank
Plxna1 8243
Plxna3 7929
Tln1 7273
Fes 7247
Plxna2 6987
Plxna4 6957
Pip5k1c 6853
Nrp1 6033
Farp2 4928
Rras 1711
Fyn 1002
Sema3a -2039
Rnd1 -2788
Rac1 -5805

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plxna1 8243
Plxna3 7929
Tln1 7273
Fes 7247
Plxna2 6987
Plxna4 6957
Pip5k1c 6853
Nrp1 6033
Farp2 4928
Rras 1711
Fyn 1002
Sema3a -2039
Rnd1 -2788
Rac1 -5805


REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
set REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize 17
pANOVA 0.00142
s.dist 0.447
p.adjustANOVA 0.0111


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mov10 8304
Src 8037
Tnrc6c 7554
Ago2 7474
Pml 7140
Ago3 7119
Ago1 7078
Ptpn11 6111
Cdk6 6068
Tnrc6a 5734
Tnrc6b 5468
Ccnd3 3488
Ccnd2 2992
Runx1 -2910
Ago4 -3819
Cbfb -4534
Ccnd1 -5133

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mov10 8304
Src 8037
Tnrc6c 7554
Ago2 7474
Pml 7140
Ago3 7119
Ago1 7078
Ptpn11 6111
Cdk6 6068
Tnrc6a 5734
Tnrc6b 5468
Ccnd3 3488
Ccnd2 2992
Runx1 -2910
Ago4 -3819
Cbfb -4534
Ccnd1 -5133


CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
set CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize 47
pANOVA 1.2e-07
s.dist -0.446
p.adjustANOVA 3.26e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Psmd8 -6424

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Psmd8 -6424
Mrc1 -5918
Psma7 -5402
Psmc5 -4630
Psmb4 -4132
Fcgr1 -3875
Psme3 -3373
Sem1 -3271
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Psmb6 -1711
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Psmd9 182
Psmf1 394
Mrc2 452
Psmd11 662
Psmb2 1247
Psmd4 1520
Psmc4 2327
Psmb11 2714
Psme4 3585
Psmb5 4174
Psmd3 7173


NEGATIVE REGULATION OF NOTCH4 SIGNALING
set NEGATIVE REGULATION OF NOTCH4 SIGNALING
setSize 54
pANOVA 1.45e-08
s.dist -0.446
p.adjustANOVA 5.47e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Fbxw7 -8220
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Rbx1 -6794
Psma1 -6698

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Fbxw7 -8220
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Rbx1 -6794
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Rps27a -6498
Psmd8 -6424
Ywhaz -6206
Psma7 -5402
Psmc5 -4630
Psmb4 -4132
Uba52 -3962
Psme3 -3373
Sem1 -3271
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Cul1 -2786
Psmb10 -2592
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 394
Psmd11 662
Psmb2 1247
Psmd4 1520
Psmc4 2327
Tacc3 2332
Psmb5 4174
Akt1 5809
Psmd3 7173
Notch4 7822


NONSENSE MEDIATED DECAY NMD
set NONSENSE MEDIATED DECAY NMD
setSize 109
pANOVA 8.89e-16
s.dist -0.446
p.adjustANOVA 9.36e-14


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8142
Rplp0 -8067
Rpl5 -8041
Rbm8a -7971
Ppp2r2a -7845
Rpl27a -7808
Rps2 -7770
Ncbp2 -7700
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Pabpc1 -7329
Etf1 -7310
Rps3a1 -7249

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8142
Rplp0 -8067
Rpl5 -8041
Rbm8a -7971
Ppp2r2a -7845
Rpl27a -7808
Rps2 -7770
Ncbp2 -7700
Rpl36a -7626
Rps24 -7593
Rpl29 -7592
Rpl26 -7530
Rpl3 -7425
Pabpc1 -7329
Etf1 -7310
Rps3a1 -7249
Ppp2ca -7196
Rpl15 -7147
Rps4x -7103
Pnrc2 -7017
Rpl6 -6989
Rps6 -6780
Rpl9 -6766
Rpl24 -6733
Magoh -6644
Rps3 -6621
Upf3b -6619
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Rpl11 -6317
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Rps13 -6052
Rps27l -5977
Rps25 -5719
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Rps9 -5360
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Rps19 -4739
Rpsa -4553
Rps11 -4521
Rpl7a -4364
Rps10 -4316
Upf2 -4069
Magohb -4002
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Rps15a -3371
Fau -3268
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Upf3a -2326
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Eif4a3 -1511
Rps21 -1427
Rplp2 -430
Rpl36 -165
Rpl37 145
Gspt2 284
Rpl10 514
Ppp2r1a 825
Rnps1 917
Rpl12 952
Rpl38 1303
Gspt1 2177
Rps28 2426
Ncbp1 3142
Eif4g1 3973
Rps29 4009
Smg8 4281
Smg7 5013
Smg6 5355
Dcp1a 5379
Smg9 6456
Casc3 7240
Smg1 7533
Upf1 7911
Smg5 8470


TRIGLYCERIDE CATABOLISM
set TRIGLYCERIDE CATABOLISM
setSize 14
pANOVA 0.00424
s.dist -0.441
p.adjustANOVA 0.0274


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fabp7 -8292
Prkacb -7642
Fabp5 -7223
Ppp1cb -7100
Abhd5 -6327
Gpd2 -5445
Ppp1ca -4022
Ppp1cc -3617
Fabp3 -3554
Cav1 -3346
Plin3 -3307
Mgll 752
Lipe 2689
Prkaca 5713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fabp7 -8292
Prkacb -7642
Fabp5 -7223
Ppp1cb -7100
Abhd5 -6327
Gpd2 -5445
Ppp1ca -4022
Ppp1cc -3617
Fabp3 -3554
Cav1 -3346
Plin3 -3307
Mgll 752
Lipe 2689
Prkaca 5713


REGULATION OF EXPRESSION OF SLITS AND ROBOS
set REGULATION OF EXPRESSION OF SLITS AND ROBOS
setSize 161
pANOVA 4.88e-22
s.dist -0.441
p.adjustANOVA 1.43e-19


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Psmc1 -8281
Psmd12 -8215
Rpl22l1 -8142
Psma6 -8084
Rplp0 -8067
Rpl5 -8041
Psma3 -8010
Rbm8a -7971
Psmc6 -7954
Eloc -7937
Rpl27a -7808
Rps2 -7770
Ncbp2 -7700
Rpl36a -7626
Psmb1 -7594
Rps24 -7593

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Psmc1 -8281
Psmd12 -8215
Rpl22l1 -8142
Psma6 -8084
Rplp0 -8067
Rpl5 -8041
Psma3 -8010
Rbm8a -7971
Psmc6 -7954
Eloc -7937
Rpl27a -7808
Rps2 -7770
Ncbp2 -7700
Rpl36a -7626
Psmb1 -7594
Rps24 -7593
Rpl29 -7592
Psmd14 -7557
Rpl26 -7530
Psmd6 -7435
Rpl3 -7425
Psma2 -7379
Psmb7 -7345
Pabpc1 -7329
Etf1 -7310
Rps3a1 -7249
Psmd10 -7236
Psma4 -7159
Rpl15 -7147
Psma5 -7121
Rps4x -7103
Psmd1 -7052
Rpl6 -6989
Cul2 -6927
Psmc2 -6813
Psmb8 -6797
Rbx1 -6794
Rps6 -6780
Rpl9 -6766
Rpl24 -6733
Psma1 -6698
Psmd7 -6680
Magoh -6644
Rps3 -6621
Upf3b -6619
Rpl7 -6615
Psme2 -6586
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Psmd8 -6424
Rpl11 -6317
Rpl14 -6265
Rpl4 -6225
Rpl22 -6170
Rps14 -6143
Rps13 -6052
Rps27l -5977
Rps25 -5719
Rpl23a -5556
Rpl18a -5542
Rpl23 -5444
Psma7 -5402
Rps9 -5360
Rpl31 -5189
Rps16 -5186
Rps20 -5082
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Rpl10a -4805
Rps19 -4739
Isl1 -4717
Psmc5 -4630
Rpsa -4553
Rps11 -4521
Slit2 -4404
Rpl7a -4364
Rps10 -4316
Psmb4 -4132
Upf2 -4069
Magohb -4002
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Rpl19 -3713
Rpl32 -3657
Rps27 -3640
Psme3 -3373
Rps15a -3371
Sem1 -3271
Fau -3268
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Rpl37a -3095
Elob -3074
Usp33 -3067
Rps5 -3041
Psmb9 -3039
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Psmb10 -2592
Upf3a -2326
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Psmb6 -1711
Ubb -1705
Eif4a3 -1511
Psmd13 -1434
Rps21 -1427
Psmb3 -868
Rplp2 -430
Rpl36 -165
Psmd2 -105
Rpl37 145
Ubc 176
Psmd9 182
Gspt2 284
Psmf1 394
Rpl10 514
Psmd11 662
Rnps1 917
Rpl12 952
Psmb2 1247
Lhx9 1292
Rpl38 1303
Psmd4 1520
Robo2 1899
Dag1 1970
Gspt1 2177
Psmc4 2327
Rps28 2426
Lhx2 2619
Psmb11 2714
Ncbp1 3142
Robo3 3270
Psme4 3585
Eif4g1 3973
Rps29 4009
Psmb5 4174
Robo1 4330
Col4a5 5235
Msi1 5489
Ldb1 6871
Psmd3 7173
Casc3 7240
Zswim8 8270
Slit1 8422


CRISTAE FORMATION
set CRISTAE FORMATION
setSize 31
pANOVA 2.29e-05
s.dist -0.439
p.adjustANOVA 0.000304


Top enriched genes
Top 20 genes
GeneID Gene Rank
Apoo -8251
Atp5pb -7850
Mtx2 -7793
Atp5c1 -7620
Hspa9 -7464
Dmac2l -7418
mt-Atp6 -7412
Atp5h -7402
Micos10 -7241
Atp5b -6703
Atp5a1 -6249
Atp5j -6243
Atp5l -5924
Atp5g3 -5789
Immt -5464
Apool -5077
Atp5o -4859
Chchd3 -4148
Atp5j2 -3790
Tmem11 -3633

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Apoo -8251
Atp5pb -7850
Mtx2 -7793
Atp5c1 -7620
Hspa9 -7464
Dmac2l -7418
mt-Atp6 -7412
Atp5h -7402
Micos10 -7241
Atp5b -6703
Atp5a1 -6249
Atp5j -6243
Atp5l -5924
Atp5g3 -5789
Immt -5464
Apool -5077
Atp5o -4859
Chchd3 -4148
Atp5j2 -3790
Tmem11 -3633
Atp5e -3320
Samm50 -2911
Chchd6 -2414
Micos13 -2255
mt-Atp8 -20
Atp5d 1602
Mtx1 3630
Dnajc11 3702
Atp5g1 4680
Atp5k 5446
Atp5g2 6510


RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
set RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize 125
pANOVA 2.77e-17
s.dist -0.438
p.adjustANOVA 3.24e-15


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
mt-Co1 -8118
Ndufaf2 -8037
Uqcrc2 -7976
Atp5pb -7850
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
mt-Nd2 -7693
Ndufa10 -7692
Ucp3 -7688
Cox20 -7657
Atp5c1 -7620
Ndufb4 -7618
Ndufaf1 -7517
Dmac2l -7418
mt-Atp6 -7412

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
mt-Co1 -8118
Ndufaf2 -8037
Uqcrc2 -7976
Atp5pb -7850
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
mt-Nd2 -7693
Ndufa10 -7692
Ucp3 -7688
Cox20 -7657
Atp5c1 -7620
Ndufb4 -7618
Ndufaf1 -7517
Dmac2l -7418
mt-Atp6 -7412
Atp5h -7402
Cox7a2l -7372
Etfa -7358
mt-Nd4 -7350
mt-Co2 -7287
mt-Cytb -7190
Ndufaf5 -7173
Sco1 -7114
Ndufb5 -7051
mt-Nd6 -7048
mt-Co3 -7030
Slc25a14 -7021
Cox7b -6992
Ndufb6 -6775
Ndufa4 -6746
Coq10b -6739
mt-Nd5 -6714
Atp5b -6703
Ndufc1 -6492
Nubpl -6403
Ndufa8 -6291
Ndufa9 -6261
Atp5a1 -6249
Atp5j -6243
Cox16 -6209
Uqcrb -6107
Ndufs2 -6095
Ndufb3 -6049
Atp5l -5924
Sdhc -5907
Ndufb9 -5884
Ndufa12 -5880
Atp5g3 -5789
Ndufa5 -5748
Cox6c -5704
Etfb -5390
Ndufs5 -5273
Ndufb2 -5054
Ndufs6 -5005
Sdhd -4866
Ndufs1 -4860
Atp5o -4859
Etfdh -4831
Ndufb11 -4705
Ndufb8 -4576
Surf1 -4554
Tmem126b -4551
Uqcrh -4434
Ndufaf6 -4411
Cox5a -4307
Cox7c -4255
Sdha -4024
Cox4i1 -3973
Ndufa6 -3971
Atp5j2 -3790
Ndufs8 -3712
Ndufs3 -3558
Sdhb -3436
Atp5e -3320
Sco2 -3312
Uqcrq -2949
Ndufaf7 -2652
Ndufv1 -2446
Cox14 -2445
Ndufa1 -2342
Pm20d1 -1959
Ndufb1 -1848
Cox19 -1734
Timmdc1 -1652
Ndufab1 -1622
Cox6b1 -1294
Lrpprc -1274
Cox6a1 -1024
Ndufaf3 -1006
Ndufa7 -922
Uqcrfs1 -898
Ndufb7 -678
Uqcr10 -621
Ndufa13 -112
mt-Atp8 -20
Ndufb10 93
Ndufa2 115
Cox5b 523
Coq10a 573
Cox8a 689
Ndufa11 762
Cyc1 766
Uqcr11 1037
Cox11 1133
Ndufv3 1317
Acad9 1433
Atp5d 1602
Uqcrc1 1967
Ndufs7 2962
Ndufa3 3435
Atp5g1 4680
Atp5k 5446
Ecsit 5458
Tmem186 5509
Cox18 6029
Taco1 6078
Atp5g2 6510
Trap1 6578
Slc25a27 7259
Ucp2 7422


NRAGE SIGNALS DEATH THROUGH JNK
set NRAGE SIGNALS DEATH THROUGH JNK
setSize 55
pANOVA 2.06e-08
s.dist 0.437
p.adjustANOVA 7.32e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Obscn 8446
Vav2 8424
Arhgef10 8317
Mcf2l 8254
Plekhg2 8208
Arhgef5 8174
Plekhg5 8021
Akap13 7921
Arhgef4 7920
Arhgef18 7880
Kalrn 7816
Arhgef7 7763
Arhgef17 7756
Arhgef2 7733
Arhgef1 7711
Trio 7556
Arhgef11 7505
Abr 7481
Rasgrf2 7291
Prex1 6989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Obscn 8446
Vav2 8424
Arhgef10 8317
Mcf2l 8254
Plekhg2 8208
Arhgef5 8174
Plekhg5 8021
Akap13 7921
Arhgef4 7920
Arhgef18 7880
Kalrn 7816
Arhgef7 7763
Arhgef17 7756
Arhgef2 7733
Arhgef1 7711
Trio 7556
Arhgef11 7505
Abr 7481
Rasgrf2 7291
Prex1 6989
Arhgef40 6959
Arhgef19 6754
Fgd1 6595
Arhgef10l 6444
Itsn1 6348
Arhgef12 6281
Arhgef6 6119
Arhgef33 5619
Fgd2 5479
Tiam1 5248
Arhgef37 4217
Tiam2 3406
Maged1 2779
Arhgef16 2425
Arhgef26 1977
Fgd3 1900
Ngf 1660
Arhgef3 1642
Vav1 1150
Aatf 1001
Gna13 948
Arhgef9 448
Net1 121
Sos1 -264
Fgd4 -322
Bad -379
Bcl2l11 -1041
Vav3 -1069
Ngef -1236
Sos2 -1968
Arhgef15 -3898
Ngfr -5355
Mapk8 -5713
Rac1 -5805
Mcf2 -6588


SCF SKP2 MEDIATED DEGRADATION OF P27 P21
set SCF SKP2 MEDIATED DEGRADATION OF P27 P21
setSize 59
pANOVA 6.54e-09
s.dist -0.437
p.adjustANOVA 2.84e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Ccne2 -7701
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Ccne2 -7701
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Rps27a -6498
Psmd8 -6424
Ccna2 -5417
Psma7 -5402
Ccnd1 -5133
Psmc5 -4630
Psmb4 -4132
Uba52 -3962
Cdkn1a -3493
Psme3 -3373
Cks1b -3321
Sem1 -3271
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Cdkn1b -2999
Cdk4 -2980
Cul1 -2786
Psmb10 -2592
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Psmb3 -868
Ccne1 -728
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 394
Psmd11 662
Psmb2 1247
Psmd4 1520
Psmc4 2327
Skp2 4011
Ccna1 4017
Psmb5 4174
Cdk2 4830
Psmd3 7173


DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
set DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
setSize 59
pANOVA 7.95e-09
s.dist -0.434
p.adjustANOVA 3.21e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Erlec1 -8119
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Derl2 -7849
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Erlec1 -8119
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Derl2 -7849
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Rps27a -6498
Rnf5 -6490
Psmd8 -6424
Vcp -6373
Psma7 -5402
Psmc5 -4630
Derl1 -4454
Psmb4 -4132
Uba52 -3962
Psme3 -3373
Sem1 -3271
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Erlin1 -2579
Rnf185 -1770
Os9 -1766
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Derl3 -1361
Psmb3 -868
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 394
Psmd11 662
Psmb2 1247
Psmd4 1520
Psmc4 2327
Sel1l 2628
Psmb11 2714
Erlin2 3058
Psme4 3585
Psmb5 4174
Psmd3 7173


SIGNALING BY LEPTIN
set SIGNALING BY LEPTIN
setSize 10
pANOVA 0.0177
s.dist 0.433
p.adjustANOVA 0.0829


Top enriched genes
Top 20 genes
GeneID Gene Rank
Sh2b1 8212
Stat3 6488
Ptpn11 6111
Stat5b 4878
Irs1 4505
Jak2 4366
Irs2 3405
Stat5a 2972
Socs3 -686
Lepr -2482

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sh2b1 8212
Stat3 6488
Ptpn11 6111
Stat5b 4878
Irs1 4505
Jak2 4366
Irs2 3405
Stat5a 2972
Socs3 -686
Lepr -2482


INTERLEUKIN 12 SIGNALING
set INTERLEUKIN 12 SIGNALING
setSize 37
pANOVA 5.32e-06
s.dist -0.432
p.adjustANOVA 8.58e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8067
Hnrnpdl -7926
Rap1b -7873
Ppia -7847
Hspa9 -7464
Rala -7437
Hnrnpa2b1 -7380
Pdcd4 -6990
Mtap -6820
Psme2 -6586
Lcp1 -5848
Capza1 -5797
Gsto1 -5547
Snrpa1 -5226
Cnn2 -5023
Pak2 -5001
Hnrnpf -4674
P4hb -4377

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8067
Hnrnpdl -7926
Rap1b -7873
Ppia -7847
Hspa9 -7464
Rala -7437
Hnrnpa2b1 -7380
Pdcd4 -6990
Mtap -6820
Psme2 -6586
Lcp1 -5848
Capza1 -5797
Gsto1 -5547
Snrpa1 -5226
Cnn2 -5023
Pak2 -5001
Hnrnpf -4674
P4hb -4377
Taldo1 -3814
Sod2 -3756
Sod1 -3216
Cfl1 -3018
Aip -2618
Jak1 -2019
Pitpna -1698
Msn -1261
Arf1 -565
Il12a -359
Bola2 -8
Anxa2 509
Lmnb1 1474
Mif 4010
Jak2 4366
Il12rb1 5225
Tyk2 8075


PROCESSING OF SMDT1
set PROCESSING OF SMDT1
setSize 16
pANOVA 0.0029
s.dist -0.43
p.adjustANOVA 0.0201


Top enriched genes
Top 20 genes
GeneID Gene Rank
Maip1 -7983
Pmpcb -7897
Micu2 -7862
Micu3 -7018
Yme1l1 -7009
Phb -6582
Mcub -6564
Parl -6116
Smdt1 -4006
Stoml2 -3741
Micu1 -1008
Phb2 -100
Pmpca 349
Spg7 1924
Mcu 2789
Afg3l2 4409

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Maip1 -7983
Pmpcb -7897
Micu2 -7862
Micu3 -7018
Yme1l1 -7009
Phb -6582
Mcub -6564
Parl -6116
Smdt1 -4006
Stoml2 -3741
Micu1 -1008
Phb2 -100
Pmpca 349
Spg7 1924
Mcu 2789
Afg3l2 4409


GLYCOGEN SYNTHESIS
set GLYCOGEN SYNTHESIS
setSize 14
pANOVA 0.00559
s.dist -0.428
p.adjustANOVA 0.0332


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ugp2 -8317
Ppp1r3c -8314
Gyg -6832
Rps27a -6498
Pgm2l1 -6100
Pgm2 -5625
Uba52 -3962
Epm2a -3491
Gbe1 -3314
Pgm1 -2590
Ubb -1705
Nhlrc1 143
Ubc 176
Gys1 7326

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ugp2 -8317
Ppp1r3c -8314
Gyg -6832
Rps27a -6498
Pgm2l1 -6100
Pgm2 -5625
Uba52 -3962
Epm2a -3491
Gbe1 -3314
Pgm1 -2590
Ubb -1705
Nhlrc1 143
Ubc 176
Gys1 7326


AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
set AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
setSize 54
pANOVA 7.11e-08
s.dist -0.424
p.adjustANOVA 2.19e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Hspa8 -7921
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Pabpc1 -7329
Hnrnpd -7319
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Psma6 -8084
Psma3 -8010
Psmc6 -7954
Hspa8 -7921
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Pabpc1 -7329
Hnrnpd -7319
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Psmd1 -7052
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Rps27a -6498
Psmd8 -6424
Psma7 -5402
Psmc5 -4630
Psmb4 -4132
Uba52 -3962
Psme3 -3373
Sem1 -3271
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 394
Psmd11 662
Hspa1a 1011
Psmb2 1247
Psmd4 1520
Psmc4 2327
Psmb11 2714
Psme4 3585
Eif4g1 3973
Psmb5 4174
Hspb1 4933
Psmd3 7173


TRANSLATION
set TRANSLATION
setSize 286
pANOVA 7.12e-35
s.dist -0.423
p.adjustANOVA 8.34e-32


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
N6amt1 -8311
Eif5b -8297
Rpl30 -8293
Spcs2 -8284
Eif4a2 -8274
Ppa1 -8273
Eif5 -8214
Eif3j2 -8207
Eif3e -8203
Eif4e -8157
Mrpl50 -8145
Rpl22l1 -8142
Mrps31 -8107
Eif2s1 -8080
Rplp0 -8067

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
N6amt1 -8311
Eif5b -8297
Rpl30 -8293
Spcs2 -8284
Eif4a2 -8274
Ppa1 -8273
Eif5 -8214
Eif3j2 -8207
Eif3e -8203
Eif4e -8157
Mrpl50 -8145
Rpl22l1 -8142
Mrps31 -8107
Eif2s1 -8080
Rplp0 -8067
Mrps22 -8060
Rpl5 -8041
Eif3m -8004
Mrps30 -7995
Nars -7989
Srp54a -7881
Mrpl15 -7865
Mrps18c -7810
Rpl27a -7808
Rps2 -7770
Spcs3 -7741
Rars -7669
Eef1g -7649
Mrpl48 -7644
Rpl36a -7626
Srp19 -7608
Mrpl1 -7606
Rps24 -7593
Rpl29 -7592
Aimp1 -7571
Ptcd3 -7538
Rpl26 -7530
Mrps36 -7477
Dars -7466
Rpl3 -7425
Gars -7394
Mrpl13 -7392
Mrpl33 -7363
Pabpc1 -7329
Mrps23 -7317
Ssr3 -7315
Etf1 -7310
Rps3a1 -7249
Sars -7191
Mrpl19 -7182
Ssr1 -7169
Rpl15 -7147
Eif3h -7128
Mrpl32 -7122
Mrpl16 -7110
Rps4x -7103
Ppa2 -7042
Rpl6 -6989
Chchd1 -6873
Mrpl47 -6861
Eif2b3 -6847
Mrpl34 -6828
Eef1b2 -6802
Rps6 -6780
Rpl9 -6766
Sec61g -6749
Rpl24 -6733
Srp14 -6721
Eif1ax -6716
Mrps25 -6673
Eif2s3x -6650
Spcs1 -6628
Mrps5 -6626
Mrps35 -6623
Rps3 -6621
Rpl7 -6615
Rps8 -6584
Rpl13a -6549
Rpl17 -6547
Rps23 -6543
Rps27a -6498
Mrpl54 -6414
Sec11a -6396
Hars -6387
Mrpl39 -6380
Mrps10 -6375
Mrpl35 -6330
Rpl11 -6317
Rpl14 -6265
Mrpl42 -6239
Rpl4 -6225
Mtif3 -6200
Rpl22 -6170
Mrpl11 -6167
Rps14 -6143
Mrpl30 -6087
Srp9 -6065
Rps13 -6052
Eif3a -6013
Trmt112 -6005
Rps27l -5977
Mrps14 -5892
Eef1a1 -5774
Eif4b -5757
Rps25 -5719
Mrpl18 -5712
Mrps33 -5651
Mrps2 -5636
Rpl23a -5556
Rpl18a -5542
Mrpl40 -5481
Tsfm -5469
Rpl23 -5444
Rps9 -5360
Eif3g -5315
Mrpl17 -5228
Sec11c -5205
Rpl31 -5189
Rps16 -5186
Mrps7 -5184
Mtrf1l -5088
Rps20 -5082
Eprs -5047
Rpl21 -5013
Rpl27 -4996
Rpl36al -4921
Mrpl24 -4886
Mrpl3 -4812
Rpl10a -4805
Mrpl23 -4774
Mrpl10 -4755
Rps19 -4739
Mtif2 -4712
Mrpl43 -4560
Rpsa -4553
Mrps18b -4542
Aurkaip1 -4523
Rps11 -4521
Rpl7a -4364
Mrpl12 -4343
Rps10 -4316
Mrpl44 -4262
Mrps18a -4233
Eif4a1 -4208
Rpn1 -4193
Eif3j1 -4147
Dars2 -4143
Mrps9 -4129
Mrps16 -4126
Mrps28 -4084
Rars2 -4081
Uba52 -3962
Rpl28 -3951
Rps26 -3866
Rps17 -3849
Mrps6 -3722
Rpl19 -3713
Mrpl49 -3669
Rpl32 -3657
Rps27 -3640
Kars -3399
Rps15a -3371
Eif4ebp1 -3363
Mrpl51 -3296
Mrpl9 -3285
Fau -3268
Tram1 -3223
Yars2 -3213
Rpl37a -3095
Mars2 -3057
Yars -3043
Rps5 -3041
Fars2 -3040
Mrps17 -3013
Rpl34 -3010
Mrpl46 -2970
Rpl18 -2938
Sec61b -2933
Mrpl41 -2811
Rpl39 -2737
Srp72 -2721
Eif3c -2718
Ssr4 -2693
Rplp1 -2691
Mrpl27 -2636
Rpl8 -2622
Eif2b5 -2578
Mrps21 -2509
Mrpl22 -2443
Ssr2 -2440
Eif3k -2431
Eif3d -2344
Mrps24 -2317
Mrpl21 -2283
Rps15 -2201
Farsb -2005
Rpl13 -1947
Mrpl52 -1931
Mrpl28 -1883
Rpl35 -1857
Rps12 -1815
Eif3f -1745
Eef1d -1550
Gadd45gip1 -1433
Rps21 -1427
Gfm1 -1293
Mrrf -1288
Lars -1221
Mrpl36 -1190
Eef1a2 -1005
Eef2 -752
Mrps12 -732
Mrps15 -685
Mrpl14 -673
Mrpl55 -613
Aimp2 -462
Rplp2 -430
Mrpl20 -372
Mrps26 -247
Rpn2 -246
Rpl36 -165
Nars2 17
Srprb 131
Rpl37 145
Ddost 192
Tars 252
Mrpl53 259
Gspt2 284
Eif3i 285
Aars 356
Rpl10 514
Mrpl2 761
Mrpl57 905
Rpl12 952
Tufm 1249
Rpl38 1303
Pars2 1529
Eif4h 1597
Mtfmt 1693
Sec61a2 1782
Mrps11 1828
Mrps34 1877
Ears2 1929
Mrpl58 1956
Hars2 2073
Eif2b4 2123
Gspt1 2177
Eif3l 2393
Rps28 2426
Eif2b1 2552
Tars2 2668
Srpr 2712
Eif3b 3056
Mrpl38 3070
Iars2 3152
Dap3 3319
Apeh 3622
Lars2 3662
Gfm2 3694
Mrps27 3878
Eif4g1 3973
Rps29 4009
Wars2 4222
Wars 4478
Iars 5548
Mrpl37 5580
Cars 5768
Oxa1l 6032
Srp68 6075
Sars2 6262
Qars 6328
Farsa 6337
Vars 6430
Mars1 6723
Eif2b2 6856
Cars2 7049
Mrpl4 7213
Sec61a1 7340
Eral1 7589
Vars2 7735
Aars2 7883


MITOCHONDRIAL TRANSLATION
set MITOCHONDRIAL TRANSLATION
setSize 93
pANOVA 1.78e-12
s.dist -0.423
p.adjustANOVA 1.1e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mrpl50 -8145
Mrps31 -8107
Mrps22 -8060
Mrps30 -7995
Mrpl15 -7865
Mrps18c -7810
Mrpl48 -7644
Mrpl1 -7606
Ptcd3 -7538
Mrps36 -7477
Mrpl13 -7392
Mrpl33 -7363
Mrps23 -7317
Mrpl19 -7182
Mrpl32 -7122
Mrpl16 -7110
Chchd1 -6873
Mrpl47 -6861
Mrpl34 -6828
Mrps25 -6673

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mrpl50 -8145
Mrps31 -8107
Mrps22 -8060
Mrps30 -7995
Mrpl15 -7865
Mrps18c -7810
Mrpl48 -7644
Mrpl1 -7606
Ptcd3 -7538
Mrps36 -7477
Mrpl13 -7392
Mrpl33 -7363
Mrps23 -7317
Mrpl19 -7182
Mrpl32 -7122
Mrpl16 -7110
Chchd1 -6873
Mrpl47 -6861
Mrpl34 -6828
Mrps25 -6673
Mrps5 -6626
Mrps35 -6623
Mrpl54 -6414
Mrpl39 -6380
Mrps10 -6375
Mrpl35 -6330
Mrpl42 -6239
Mtif3 -6200
Mrpl11 -6167
Mrpl30 -6087
Mrps14 -5892
Mrpl18 -5712
Mrps33 -5651
Mrps2 -5636
Mrpl40 -5481
Tsfm -5469
Mrpl17 -5228
Mrps7 -5184
Mtrf1l -5088
Mrpl24 -4886
Mrpl3 -4812
Mrpl23 -4774
Mrpl10 -4755
Mtif2 -4712
Mrpl43 -4560
Mrps18b -4542
Aurkaip1 -4523
Mrpl12 -4343
Mrpl44 -4262
Mrps18a -4233
Mrps9 -4129
Mrps16 -4126
Mrps28 -4084
Mrps6 -3722
Mrpl49 -3669
Mrpl51 -3296
Mrpl9 -3285
Mrps17 -3013
Mrpl46 -2970
Mrpl41 -2811
Mrpl27 -2636
Mrps21 -2509
Mrpl22 -2443
Mrps24 -2317
Mrpl21 -2283
Mrpl52 -1931
Mrpl28 -1883
Gadd45gip1 -1433
Gfm1 -1293
Mrrf -1288
Mrpl36 -1190
Mrps12 -732
Mrps15 -685
Mrpl14 -673
Mrpl55 -613
Mrpl20 -372
Mrps26 -247
Mrpl53 259
Mrpl2 761
Mrpl57 905
Tufm 1249
Mtfmt 1693
Mrps11 1828
Mrps34 1877
Mrpl58 1956
Mrpl38 3070
Dap3 3319
Gfm2 3694
Mrps27 3878
Mrpl37 5580
Oxa1l 6032
Mrpl4 7213
Eral1 7589


FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
set FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize 18
pANOVA 0.0019
s.dist -0.423
p.adjustANOVA 0.014


Top enriched genes
Top 20 genes
GeneID Gene Rank
Atp5pb -7850
Atp5c1 -7620
Dmac2l -7418
mt-Atp6 -7412
Atp5h -7402
Atp5b -6703
Atp5a1 -6249
Atp5j -6243
Atp5l -5924
Atp5g3 -5789
Atp5o -4859
Atp5j2 -3790
Atp5e -3320
mt-Atp8 -20
Atp5d 1602
Atp5g1 4680
Atp5k 5446
Atp5g2 6510

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5pb -7850
Atp5c1 -7620
Dmac2l -7418
mt-Atp6 -7412
Atp5h -7402
Atp5b -6703
Atp5a1 -6249
Atp5j -6243
Atp5l -5924
Atp5g3 -5789
Atp5o -4859
Atp5j2 -3790
Atp5e -3320
mt-Atp8 -20
Atp5d 1602
Atp5g1 4680
Atp5k 5446
Atp5g2 6510


METABOLISM OF POLYAMINES
set METABOLISM OF POLYAMINES
setSize 58
pANOVA 3.05e-08
s.dist -0.42
p.adjustANOVA 1.05e-06


Top enriched genes
Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Amd1 -8100
Psma6 -8084
Sat1 -8038
Psma3 -8010
Psmc6 -7954
Sms -7782
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Oaz3 -7088
Psmd1 -7052
Oaz2 -6913
Psmc2 -6813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8215
Amd1 -8100
Psma6 -8084
Sat1 -8038
Psma3 -8010
Psmc6 -7954
Sms -7782
Psmb1 -7594
Psmd14 -7557
Psmd6 -7435
Psma2 -7379
Psmb7 -7345
Psmd10 -7236
Psma4 -7159
Psma5 -7121
Oaz3 -7088
Psmd1 -7052
Oaz2 -6913
Psmc2 -6813
Psmb8 -6797
Psma1 -6698
Psmd7 -6680
Psme2 -6586
Psmd8 -6424
Nqo1 -5965
Psma7 -5402
Psmc5 -4630
Azin1 -4613
Psmb4 -4132
Oaz1 -4003
Odc1 -3910
Paox -3582
Psme3 -3373
Sem1 -3271
Psmd5 -3242
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Psmb6 -1711
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Psmd9 182
Psmf1 394
Psmd11 662
Psmb2 1247
Psmd4 1520
Agmat 1992
Psmc4 2327
Psmb11 2714
Psme4 3585
Psmb5 4174
Azin2 5127
Psmd3 7173
Srm 7559
Smox 8549


SYNAPTIC ADHESION LIKE MOLECULES
set SYNAPTIC ADHESION LIKE MOLECULES
setSize 21
pANOVA 0.00088
s.dist 0.419
p.adjustANOVA 0.00747


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptprs 8536
Grin2c 8251
Grin1 8151
Ptprf 7635
Lrfn2 7443
Grin2d 7184
Grin2a 7147
Grin2b 6028
Lrfn1 5731
Gria1 5628
Lrfn4 5585
Dlg4 4884
Flot2 4868
Lrfn3 4376
Dlg3 2734
Flot1 2124
Ptprd 796
Gria3 -1082
Dlg1 -6020
Gria4 -6219

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptprs 8536
Grin2c 8251
Grin1 8151
Ptprf 7635
Lrfn2 7443
Grin2d 7184
Grin2a 7147
Grin2b 6028
Lrfn1 5731
Gria1 5628
Lrfn4 5585
Dlg4 4884
Flot2 4868
Lrfn3 4376
Dlg3 2734
Flot1 2124
Ptprd 796
Gria3 -1082
Dlg1 -6020
Gria4 -6219
Rtn3 -6951


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 0.00025
s.dist -0.415
p.adjustANOVA 0.00244


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cct6a -8302
Tcp1 -8258
Vbp1 -8132
Cct2 -8115
Pfdn4 -8043
Cct4 -7977
Cct8 -7761
Pfdn1 -6379
Cct3 -6262
Cct7 -5895
Pfdn2 -5609
Pfdn5 -4228
Cct5 -4079
Pfdn6 -3886
Tuba4a -3430
Tuba1b -3401
Tuba1a -3146
Tuba8 -1901
Tubb6 -1519
Actb -1167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a -8302
Tcp1 -8258
Vbp1 -8132
Cct2 -8115
Pfdn4 -8043
Cct4 -7977
Cct8 -7761
Pfdn1 -6379
Cct3 -6262
Cct7 -5895
Pfdn2 -5609
Pfdn5 -4228
Cct5 -4079
Pfdn6 -3886
Tuba4a -3430
Tuba1b -3401
Tuba1a -3146
Tuba8 -1901
Tubb6 -1519
Actb -1167
Tubb4b -822
Tubb3 441
Tubb2b 1632
Tubb2a 4728
Tubb4a 4796
Tuba1c 8405


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 10
pANOVA 0.0237
s.dist -0.413
p.adjustANOVA 0.104


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ywhaq -8300
Ywhab -8050
Ywhae -7950
Ywhah -6974
Ywhaz -6206
Chek2 -5937
Chek1 -3066
Wee1 953
Ywhag 4937
Sfn 6757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ywhaq -8300
Ywhab -8050
Ywhae -7950
Ywhah -6974
Ywhaz -6206
Chek2 -5937
Chek1 -3066
Wee1 953
Ywhag 4937
Sfn 6757


G BETA GAMMA SIGNALLING THROUGH CDC42
set G BETA GAMMA SIGNALLING THROUGH CDC42
setSize 18
pANOVA 0.00246
s.dist -0.412
p.adjustANOVA 0.0174


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gng11 -8252
Cdc42 -8238
Pak1 -8117
Gng10 -7222
Gng12 -7195
Gnb4 -5410
Gngt2 -5364
Gnb1 -5116
Gng5 -4385
Gng2 -4120
Gng3 -4034
Gng4 -2468
Gng13 -2173
Gnb5 -454
Gng8 918
Gnb2 2173
Gng7 2569
Arhgef6 6119

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng11 -8252
Cdc42 -8238
Pak1 -8117
Gng10 -7222
Gng12 -7195
Gnb4 -5410
Gngt2 -5364
Gnb1 -5116
Gng5 -4385
Gng2 -4120
Gng3 -4034
Gng4 -2468
Gng13 -2173
Gnb5 -454
Gng8 918
Gnb2 2173
Gng7 2569
Arhgef6 6119


ACTIVATION OF SMO
set ACTIVATION OF SMO
setSize 16
pANOVA 0.0047
s.dist 0.408
p.adjustANOVA 0.0294


Top enriched genes
Top 20 genes
GeneID Gene Rank
Arrb2 8040
Evc2 7667
Smo 7655
Boc 6969
Iqce 6687
Cdon 6013
Gas8 5836
Arrb1 5262
Evc 5258
Grk2 5052
Ptch1 4947
Gas1 1457
Kif3a -2304
Csnk1a1 -2327
Shh -3499
Efcab7 -5662

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Arrb2 8040
Evc2 7667
Smo 7655
Boc 6969
Iqce 6687
Cdon 6013
Gas8 5836
Arrb1 5262
Evc 5258
Grk2 5052
Ptch1 4947
Gas1 1457
Kif3a -2304
Csnk1a1 -2327
Shh -3499
Efcab7 -5662


THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
set THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
setSize 172
pANOVA 2.98e-20
s.dist -0.407
p.adjustANOVA 5.82e-18


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cycs -8327
Slc16a1 -8316
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
mt-Co1 -8118
Dld -8104
Ndufaf2 -8037
Uqcrc2 -7976
Atp5pb -7850
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
Fh1 -7718
mt-Nd2 -7693
Ndufa10 -7692
Ucp3 -7688
Cox20 -7657
Glo1 -7632
Atp5c1 -7620

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8327
Slc16a1 -8316
Ndufv2 -8225
mt-Nd3 -8218
Ndufc2 -8185
mt-Co1 -8118
Dld -8104
Ndufaf2 -8037
Uqcrc2 -7976
Atp5pb -7850
Ndufaf4 -7813
Ndufs4 -7783
mt-Nd1 -7777
Fh1 -7718
mt-Nd2 -7693
Ndufa10 -7692
Ucp3 -7688
Cox20 -7657
Glo1 -7632
Atp5c1 -7620
Ndufb4 -7618
Ndufaf1 -7517
Mpc2 -7460
Sucla2 -7431
Dmac2l -7418
mt-Atp6 -7412
Pdha1 -7406
Atp5h -7402
Cox7a2l -7372
Pdhb -7365
Etfa -7358
mt-Nd4 -7350
Vdac1 -7309
mt-Co2 -7287
mt-Cytb -7190
Ndufaf5 -7173
Sco1 -7114
Idh3a -7069
Ndufb5 -7051
Suclg2 -7050
mt-Nd6 -7048
mt-Co3 -7030
Slc25a14 -7021
Me1 -6994
Cox7b -6992
Mpc1 -6942
Pdp1 -6810
Ndufb6 -6775
Ndufa4 -6746
Coq10b -6739
mt-Nd5 -6714
Atp5b -6703
Ndufc1 -6492
Nubpl -6403
Bsg -6402
Ndufa8 -6291
Ndufa9 -6261
Atp5a1 -6249
Atp5j -6243
Fahd1 -6234
Cox16 -6209
Uqcrb -6107
Ndufs2 -6095
Ndufb3 -6049
Atp5l -5924
Sdhc -5907
Ndufb9 -5884
Ndufa12 -5880
Atp5g3 -5789
Ndufa5 -5748
Cox6c -5704
Adhfe1 -5512
Pdhx -5466
Suclg1 -5407
Pdk3 -5400
Etfb -5390
Ldha -5321
Ndufs5 -5273
Ndufb2 -5054
Ndufs6 -5005
Sdhd -4866
Ndufs1 -4860
Atp5o -4859
Etfdh -4831
Ldhb -4798
Ndufb11 -4705
Me2 -4668
Ndufb8 -4576
L2hgdh -4574
Surf1 -4554
Tmem126b -4551
Dlat -4459
Uqcrh -4434
Ndufaf6 -4411
Cox5a -4307
Cox7c -4255
Sdha -4024
Pdp2 -4000
Cox4i1 -3973
Ndufa6 -3971
Atp5j2 -3790
Ndufs8 -3712
Ndufs3 -3558
Sdhb -3436
Atp5e -3320
Sco2 -3312
Uqcrq -2949
Pdk4 -2902
Ndufaf7 -2652
Cs -2586
Ndufv1 -2446
Cox14 -2445
Ndufa1 -2342
Pm20d1 -1959
Gstz1 -1919
Ndufb1 -1848
Cox19 -1734
Timmdc1 -1652
Ndufab1 -1622
Cox6b1 -1294
Lrpprc -1274
Cox6a1 -1024
Ndufaf3 -1006
Ndufa7 -922
Uqcrfs1 -898
Aco2 -835
Slc16a3 -829
Ndufb7 -678
Uqcr10 -621
Hagh -386
Idh3b -365
Nnt -333
Ndufa13 -112
mt-Atp8 -20
Ndufb10 93
Ndufa2 115
Mdh2 162
Cox5b 523
Coq10a 573
Cox8a 689
Ndufa11 762
Cyc1 766
Me3 942
Uqcr11 1037
Cox11 1133
Ndufv3 1317
Acad9 1433
Atp5d 1602
Uqcrc1 1967
Pdk2 2095
Ogdh 2424
Dlst 2720
Ndufs7 2962
Ndufa3 3435
Pdk1 3943
Pdpr 4072
Idh3g 4364
Atp5g1 4680
Atp5k 5446
Ecsit 5458
Tmem186 5509
Rxra 5914
Cox18 6029
Taco1 6078
D2hgdh 6191
Slc16a8 6238
Atp5g2 6510
Trap1 6578
Idh2 6753
Slc25a27 7259
Ucp2 7422
Ppard 8046


CROSSLINKING OF COLLAGEN FIBRILS
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 15
pANOVA 0.00645
s.dist 0.406
p.adjustANOVA 0.0367


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pxdn 8425
Col4a3 7551
Loxl3 7503
Col4a2 6282
Col4a1 5898
Col4a5 5235
Bmp1 4602
Col4a4 4595
Loxl1 4225
Tll2 2654
Col1a1 1862
Pcolce 67
Loxl2 -1046
Tll1 -1920
Col1a2 -2692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pxdn 8425
Col4a3 7551
Loxl3 7503
Col4a2 6282
Col4a1 5898
Col4a5 5235
Bmp1 4602
Col4a4 4595
Loxl1 4225
Tll2 2654
Col1a1 1862
Pcolce 67
Loxl2 -1046
Tll1 -1920
Col1a2 -2692


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report