date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik 0.0259293 0.4565576
0610009E02Rik 0.7519591 -0.4069908
0610009L18Rik -1.0644467 -0.1869110
0610010K14Rik 0.4476085 -0.3711485
0610012G03Rik -0.1633199 -0.3421633
0610030E20Rik -0.6249661 0.0842539

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 17476
duplicated_genes_present 0
num_profile_genes_in_sets 8392
num_profile_genes_not_in_sets 9084
profile_pearson_correl 0.66905
profile_spearman_correl 0.65197

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 427
num_genesets_included 1177

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 290

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 9.55e-04 8.20e-03 0.784 0.6080 0.4940 2.64e-04 3.03e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.42e-07 9.82e-06 0.777 0.7070 0.3200 9.34e-08 1.56e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 2.27e-03 1.50e-02 0.741 0.5600 0.4860 7.90e-04 3.58e-03
RHOBTB3 ATPASE CYCLE 10 7.23e-03 3.34e-02 0.729 0.5530 0.4750 2.44e-03 9.32e-03
CITRIC ACID CYCLE TCA CYCLE 22 3.58e-05 6.57e-04 0.716 0.5110 0.5020 3.38e-05 4.56e-05
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.81e-05 5.33e-04 0.700 0.5340 0.4530 9.29e-06 1.72e-04
OLFACTORY SIGNALING PATHWAY 37 1.31e-07 5.93e-06 0.686 -0.4720 -0.4990 6.84e-07 1.53e-07
CALNEXIN CALRETICULIN CYCLE 26 3.25e-05 6.07e-04 0.661 0.4550 0.4800 5.89e-05 2.31e-05
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 2.16e-03 1.46e-02 0.646 0.5750 0.2950 5.67e-04 7.70e-02
NUCLEOBASE BIOSYNTHESIS 15 2.74e-03 1.71e-02 0.637 0.5070 0.3850 6.69e-04 9.91e-03
RETROGRADE NEUROTROPHIN SIGNALLING 13 1.03e-02 4.42e-02 0.622 0.4520 0.4270 4.76e-03 7.73e-03
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.30e-05 2.89e-04 0.595 0.4200 0.4220 1.73e-05 1.53e-05
BRANCHED CHAIN AMINO ACID CATABOLISM 21 8.16e-04 7.38e-03 0.592 0.3590 0.4700 4.41e-03 1.90e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.27e-04 6.85e-03 0.591 0.3490 0.4770 5.65e-03 1.56e-04
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 2.06e-03 1.42e-02 0.582 0.3970 0.4260 2.10e-03 9.74e-04
LDL CLEARANCE 16 7.81e-03 3.51e-02 0.570 0.4370 0.3650 2.46e-03 1.14e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 8.80e-08 4.50e-06 0.567 0.4940 0.2800 1.47e-08 1.31e-03
GLYCOSPHINGOLIPID METABOLISM 38 1.56e-05 3.23e-04 0.567 0.4070 0.3950 1.44e-05 2.57e-05
RECEPTOR MEDIATED MITOPHAGY 11 4.27e-02 1.26e-01 0.555 0.4240 0.3570 1.49e-02 4.02e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 6.22e-02 1.61e-01 0.548 0.4140 0.3590 2.34e-02 4.90e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 4.38e-02 1.29e-01 0.548 0.3020 0.4570 9.78e-02 1.24e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.64e-04 3.24e-03 0.540 0.5350 0.0689 8.35e-04 6.67e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 3.81e-02 1.17e-01 0.537 0.4170 0.3390 1.24e-02 4.19e-02
KERATAN SULFATE BIOSYNTHESIS 24 5.51e-05 9.26e-04 0.536 0.4970 0.2010 2.54e-05 8.79e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 1.51e-02 5.77e-02 0.533 0.2670 0.4620 9.61e-02 3.95e-03
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 7.39e-04 6.91e-03 0.529 0.3270 0.4160 3.27e-03 1.85e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 4.70e-03 2.46e-02 0.525 0.3980 0.3430 1.61e-03 6.45e-03
GLYCOGEN SYNTHESIS 14 1.42e-02 5.57e-02 0.522 0.4490 0.2660 3.62e-03 8.49e-02
GLYCOGEN STORAGE DISEASES 12 2.09e-02 7.37e-02 0.507 0.4540 0.2250 6.43e-03 1.77e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.08e-05 2.49e-04 0.506 0.3700 0.3460 7.32e-06 2.86e-05
INSULIN PROCESSING 24 3.91e-03 2.16e-02 0.504 0.3470 0.3660 3.26e-03 1.93e-03
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.16e-03 1.46e-02 0.502 0.0586 0.4990 7.37e-01 4.19e-03
GLYCOGEN METABOLISM 25 1.68e-03 1.25e-02 0.499 0.4130 0.2800 3.53e-04 1.52e-02
FATTY ACYL COA BIOSYNTHESIS 32 7.25e-04 6.85e-03 0.499 0.3430 0.3620 7.79e-04 4.00e-04
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.99e-05 3.97e-04 0.498 0.4770 0.1420 2.52e-05 2.11e-01
KERATAN SULFATE KERATIN METABOLISM 30 3.72e-05 6.64e-04 0.498 0.4570 0.1970 1.46e-05 6.20e-02
SPHINGOLIPID METABOLISM 80 6.26e-09 4.09e-07 0.495 0.3010 0.3930 3.31e-06 1.21e-09
CD28 DEPENDENT VAV1 PATHWAY 11 5.58e-02 1.50e-01 0.491 0.4180 0.2570 1.64e-02 1.40e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 1.13e-05 2.57e-04 0.489 0.3840 0.3040 2.69e-06 2.04e-04
CTLA4 INHIBITORY SIGNALING 20 1.16e-02 4.80e-02 0.487 0.3100 0.3760 1.65e-02 3.58e-03
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 2.78e-02 9.23e-02 0.487 0.2810 0.3980 5.97e-02 7.59e-03
SCAVENGING OF HEME FROM PLASMA 11 4.79e-02 1.35e-01 0.485 -0.2340 -0.4250 1.79e-01 1.46e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.43e-02 1.09e-01 0.482 0.4150 0.2460 9.62e-03 1.25e-01
MET ACTIVATES RAP1 AND RAC1 10 2.86e-02 9.40e-02 0.480 0.1590 0.4530 3.83e-01 1.32e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.25e-03 2.30e-02 0.480 0.4070 0.2540 9.57e-04 3.92e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.89e-02 1.55e-01 0.479 0.3000 0.3740 6.11e-02 1.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 6.14e-02 1.60e-01 0.478 0.3930 0.2710 1.83e-02 1.04e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 5.14e-10 5.04e-08 0.473 0.4650 0.0873 2.44e-08 2.95e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 1.40e-03 1.12e-02 0.473 0.2380 0.4090 3.57e-02 3.06e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.42e-04 1.89e-03 0.470 0.0141 0.4700 9.22e-01 1.13e-03


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 9.55e-04 8.20e-03 0.78400 6.08e-01 0.494000 2.64e-04 3.03e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.42e-07 9.82e-06 0.77700 7.07e-01 0.320000 9.34e-08 1.56e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 2.27e-03 1.50e-02 0.74100 5.60e-01 0.486000 7.90e-04 3.58e-03
RHOBTB3 ATPASE CYCLE 10 7.23e-03 3.34e-02 0.72900 5.53e-01 0.475000 2.44e-03 9.32e-03
CITRIC ACID CYCLE TCA CYCLE 22 3.58e-05 6.57e-04 0.71600 5.11e-01 0.502000 3.38e-05 4.56e-05
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.81e-05 5.33e-04 0.70000 5.34e-01 0.453000 9.29e-06 1.72e-04
OLFACTORY SIGNALING PATHWAY 37 1.31e-07 5.93e-06 0.68600 -4.72e-01 -0.499000 6.84e-07 1.53e-07
CALNEXIN CALRETICULIN CYCLE 26 3.25e-05 6.07e-04 0.66100 4.55e-01 0.480000 5.89e-05 2.31e-05
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 2.16e-03 1.46e-02 0.64600 5.75e-01 0.295000 5.67e-04 7.70e-02
NUCLEOBASE BIOSYNTHESIS 15 2.74e-03 1.71e-02 0.63700 5.07e-01 0.385000 6.69e-04 9.91e-03
RETROGRADE NEUROTROPHIN SIGNALLING 13 1.03e-02 4.42e-02 0.62200 4.52e-01 0.427000 4.76e-03 7.73e-03
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.30e-05 2.89e-04 0.59500 4.20e-01 0.422000 1.73e-05 1.53e-05
BRANCHED CHAIN AMINO ACID CATABOLISM 21 8.16e-04 7.38e-03 0.59200 3.59e-01 0.470000 4.41e-03 1.90e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.27e-04 6.85e-03 0.59100 3.49e-01 0.477000 5.65e-03 1.56e-04
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 2.06e-03 1.42e-02 0.58200 3.97e-01 0.426000 2.10e-03 9.74e-04
LDL CLEARANCE 16 7.81e-03 3.51e-02 0.57000 4.37e-01 0.365000 2.46e-03 1.14e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 8.80e-08 4.50e-06 0.56700 4.94e-01 0.280000 1.47e-08 1.31e-03
GLYCOSPHINGOLIPID METABOLISM 38 1.56e-05 3.23e-04 0.56700 4.07e-01 0.395000 1.44e-05 2.57e-05
RECEPTOR MEDIATED MITOPHAGY 11 4.27e-02 1.26e-01 0.55500 4.24e-01 0.357000 1.49e-02 4.02e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 6.22e-02 1.61e-01 0.54800 4.14e-01 0.359000 2.34e-02 4.90e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 4.38e-02 1.29e-01 0.54800 3.02e-01 0.457000 9.78e-02 1.24e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.64e-04 3.24e-03 0.54000 5.35e-01 0.068900 8.35e-04 6.67e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 3.81e-02 1.17e-01 0.53700 4.17e-01 0.339000 1.24e-02 4.19e-02
KERATAN SULFATE BIOSYNTHESIS 24 5.51e-05 9.26e-04 0.53600 4.97e-01 0.201000 2.54e-05 8.79e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 1.51e-02 5.77e-02 0.53300 2.67e-01 0.462000 9.61e-02 3.95e-03
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 7.39e-04 6.91e-03 0.52900 3.27e-01 0.416000 3.27e-03 1.85e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 4.70e-03 2.46e-02 0.52500 3.98e-01 0.343000 1.61e-03 6.45e-03
GLYCOGEN SYNTHESIS 14 1.42e-02 5.57e-02 0.52200 4.49e-01 0.266000 3.62e-03 8.49e-02
GLYCOGEN STORAGE DISEASES 12 2.09e-02 7.37e-02 0.50700 4.54e-01 0.225000 6.43e-03 1.77e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.08e-05 2.49e-04 0.50600 3.70e-01 0.346000 7.32e-06 2.86e-05
INSULIN PROCESSING 24 3.91e-03 2.16e-02 0.50400 3.47e-01 0.366000 3.26e-03 1.93e-03
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.16e-03 1.46e-02 0.50200 5.86e-02 0.499000 7.37e-01 4.19e-03
GLYCOGEN METABOLISM 25 1.68e-03 1.25e-02 0.49900 4.13e-01 0.280000 3.53e-04 1.52e-02
FATTY ACYL COA BIOSYNTHESIS 32 7.25e-04 6.85e-03 0.49900 3.43e-01 0.362000 7.79e-04 4.00e-04
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.99e-05 3.97e-04 0.49800 4.77e-01 0.142000 2.52e-05 2.11e-01
KERATAN SULFATE KERATIN METABOLISM 30 3.72e-05 6.64e-04 0.49800 4.57e-01 0.197000 1.46e-05 6.20e-02
SPHINGOLIPID METABOLISM 80 6.26e-09 4.09e-07 0.49500 3.01e-01 0.393000 3.31e-06 1.21e-09
CD28 DEPENDENT VAV1 PATHWAY 11 5.58e-02 1.50e-01 0.49100 4.18e-01 0.257000 1.64e-02 1.40e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 1.13e-05 2.57e-04 0.48900 3.84e-01 0.304000 2.69e-06 2.04e-04
CTLA4 INHIBITORY SIGNALING 20 1.16e-02 4.80e-02 0.48700 3.10e-01 0.376000 1.65e-02 3.58e-03
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 2.78e-02 9.23e-02 0.48700 2.81e-01 0.398000 5.97e-02 7.59e-03
SCAVENGING OF HEME FROM PLASMA 11 4.79e-02 1.35e-01 0.48500 -2.34e-01 -0.425000 1.79e-01 1.46e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.43e-02 1.09e-01 0.48200 4.15e-01 0.246000 9.62e-03 1.25e-01
MET ACTIVATES RAP1 AND RAC1 10 2.86e-02 9.40e-02 0.48000 1.59e-01 0.453000 3.83e-01 1.32e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.25e-03 2.30e-02 0.48000 4.07e-01 0.254000 9.57e-04 3.92e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.89e-02 1.55e-01 0.47900 3.00e-01 0.374000 6.11e-02 1.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 6.14e-02 1.60e-01 0.47800 3.93e-01 0.271000 1.83e-02 1.04e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 5.14e-10 5.04e-08 0.47300 4.65e-01 0.087300 2.44e-08 2.95e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 1.40e-03 1.12e-02 0.47300 2.38e-01 0.409000 3.57e-02 3.06e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.42e-04 1.89e-03 0.47000 1.41e-02 0.470000 9.22e-01 1.13e-03
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 3.63e-05 6.57e-04 0.47000 3.24e-01 0.340000 6.19e-05 2.64e-05
CYTOSOLIC TRNA AMINOACYLATION 24 2.35e-03 1.52e-02 0.47000 4.08e-01 0.232000 5.41e-04 4.88e-02
PURINE SALVAGE 12 3.39e-02 1.08e-01 0.46600 4.22e-01 0.199000 1.14e-02 2.34e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.84e-04 4.26e-03 0.46300 4.39e-01 0.144000 2.64e-04 2.31e-01
HYALURONAN UPTAKE AND DEGRADATION 11 1.20e-01 2.59e-01 0.46000 3.36e-01 0.314000 5.34e-02 7.17e-02
RAP1 SIGNALLING 15 5.49e-02 1.49e-01 0.46000 3.10e-01 0.340000 3.79e-02 2.26e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 3.81e-02 1.17e-01 0.45900 3.94e-01 0.235000 1.08e-02 1.27e-01
GAP JUNCTION ASSEMBLY 21 5.99e-05 9.67e-04 0.45700 4.54e-01 0.053500 3.13e-04 6.71e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 8.54e-02 2.04e-01 0.45700 3.21e-01 0.325000 4.53e-02 4.24e-02
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 7.82e-02 1.92e-01 0.45600 -2.33e-01 -0.392000 1.81e-01 2.44e-02
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.09e-02 1.96e-01 0.45600 2.94e-01 0.348000 6.64e-02 2.97e-02
ENDOSOMAL VACUOLAR PATHWAY 10 2.25e-03 1.50e-02 0.45500 -4.53e-01 0.045200 1.32e-02 8.04e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.42e-02 5.57e-02 0.45200 2.21e-01 0.394000 1.05e-01 3.79e-03
PEROXISOMAL LIPID METABOLISM 27 6.79e-03 3.16e-02 0.45100 3.13e-01 0.325000 4.91e-03 3.44e-03
RESPONSE OF MTB TO PHAGOCYTOSIS 21 1.33e-02 5.31e-02 0.44800 3.70e-01 0.252000 3.30e-03 4.52e-02
FERTILIZATION 13 4.19e-02 1.25e-01 0.44800 -2.06e-01 -0.397000 1.98e-01 1.31e-02
RHO GTPASES ACTIVATE IQGAPS 23 3.96e-04 4.27e-03 0.44500 4.28e-01 0.120000 3.80e-04 3.20e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 4.48e-09 3.10e-07 0.44400 3.76e-01 0.236000 5.73e-10 9.88e-05
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.34e-01 2.80e-01 0.44200 3.66e-01 0.248000 4.51e-02 1.74e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 9.62e-02 2.21e-01 0.44200 2.91e-01 0.332000 6.91e-02 3.80e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 5.28e-05 9.01e-04 0.44000 2.04e-01 0.390000 2.23e-02 1.22e-05
RAF ACTIVATION 34 2.65e-03 1.67e-02 0.43900 3.11e-01 0.309000 1.68e-03 1.81e-03
VLDLR INTERNALISATION AND DEGRADATION 12 1.05e-01 2.34e-01 0.43800 3.52e-01 0.262000 3.50e-02 1.16e-01
PROLONGED ERK ACTIVATION EVENTS 13 4.66e-02 1.33e-01 0.43800 2.00e-01 0.390000 2.13e-01 1.49e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 3.95e-03 2.16e-02 0.43800 4.36e-01 -0.036400 1.69e-02 8.42e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 1.79e-02 6.61e-02 0.43400 4.08e-01 0.146000 8.17e-03 3.44e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 1.36e-05 2.91e-04 0.43200 3.34e-01 0.274000 3.77e-06 1.54e-04
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 5.67e-02 1.50e-01 0.43200 1.44e-01 0.407000 4.31e-01 2.58e-02
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 5.67e-02 1.50e-01 0.43200 1.44e-01 0.407000 4.31e-01 2.58e-02
PLATELET SENSITIZATION BY LDL 15 4.73e-02 1.34e-01 0.43000 2.23e-01 0.368000 1.34e-01 1.37e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 6.38e-03 3.04e-02 0.43000 -1.55e-02 0.430000 9.32e-01 1.86e-02
KILLING MECHANISMS 11 1.27e-01 2.70e-01 0.42800 -3.53e-01 -0.241000 4.24e-02 1.66e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 1.16e-02 4.80e-02 0.42600 2.92e-01 0.310000 8.68e-03 5.28e-03
RECYCLING PATHWAY OF L1 40 1.39e-04 1.88e-03 0.42600 3.79e-01 0.194000 3.40e-05 3.38e-02
EPHRIN SIGNALING 19 4.42e-02 1.29e-01 0.42500 2.99e-01 0.303000 2.41e-02 2.24e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 1.93e-02 6.91e-02 0.42500 4.18e-01 0.078900 1.65e-02 6.50e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 8.39e-02 2.01e-01 0.42500 -3.15e-01 -0.286000 3.49e-02 5.55e-02
CS DS DEGRADATION 14 3.53e-02 1.12e-01 0.42400 3.86e-01 0.175000 1.24e-02 2.56e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 7.58e-02 1.89e-01 0.42100 -3.05e-01 -0.290000 3.47e-02 4.44e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.50e-01 2.98e-01 0.42000 3.56e-01 0.224000 5.14e-02 2.20e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 4.73e-02 1.34e-01 0.42000 2.56e-01 0.332000 5.96e-02 1.47e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 53 1.76e-04 2.28e-03 0.41900 -2.70e-01 -0.320000 6.78e-04 5.53e-05
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 9.89e-03 4.26e-02 0.41800 3.58e-01 0.216000 2.43e-03 6.76e-02
N GLYCAN ANTENNAE ELONGATION 15 1.41e-03 1.12e-02 0.41700 4.17e-01 0.011000 5.19e-03 9.41e-01
SPRY REGULATION OF FGF SIGNALING 16 7.41e-02 1.85e-01 0.41600 3.22e-01 0.264000 2.59e-02 6.75e-02
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.63e-02 2.05e-01 0.41600 2.62e-01 0.323000 7.92e-02 3.02e-02
DERMATAN SULFATE BIOSYNTHESIS 11 1.57e-01 3.08e-01 0.41600 3.32e-01 0.250000 5.65e-02 1.51e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 7.55e-03 3.44e-02 0.41500 3.33e-01 0.247000 1.90e-03 2.15e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 5.64e-02 1.50e-01 0.41300 2.10e-01 0.356000 1.60e-01 1.69e-02
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 1.15e-03 9.57e-03 0.41300 3.45e-01 0.227000 2.33e-04 1.55e-02
COHESIN LOADING ONTO CHROMATIN 10 1.68e-03 1.25e-02 0.41100 -1.54e-01 0.381000 4.01e-01 3.70e-02
INTRA GOLGI TRAFFIC 43 3.02e-04 3.52e-03 0.40900 2.06e-01 0.353000 1.95e-02 6.08e-05
GOLGI TO ER RETROGRADE TRANSPORT 119 4.76e-10 5.04e-08 0.40800 3.47e-01 0.214000 5.94e-11 5.45e-05
CARNITINE METABOLISM 14 1.63e-03 1.23e-02 0.40800 -1.77e-02 0.408000 9.09e-01 8.26e-03
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 1.87e-02 6.78e-02 0.40800 3.32e-01 0.237000 4.92e-03 4.46e-02
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 8.40e-02 2.01e-01 0.40200 3.71e-01 0.156000 3.32e-02 3.70e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 1.15e-02 4.80e-02 0.40200 3.02e-01 0.266000 4.23e-03 1.18e-02
ACYL CHAIN REMODELLING OF PG 10 1.67e-01 3.19e-01 0.40200 2.06e-01 0.345000 2.59e-01 5.91e-02
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 1.51e-01 3.00e-01 0.39800 2.65e-01 0.297000 9.79e-02 6.39e-02
RHOF GTPASE CYCLE 41 3.96e-04 4.27e-03 0.39800 1.85e-01 0.352000 4.09e-02 9.49e-05
ERKS ARE INACTIVATED 13 1.50e-01 2.98e-01 0.39700 2.59e-01 0.301000 1.06e-01 6.02e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 2.31e-01 4.01e-01 0.39400 -3.05e-01 -0.249000 9.45e-02 1.72e-01
LYSOSOME VESICLE BIOGENESIS 33 6.35e-03 3.04e-02 0.39200 3.19e-01 0.228000 1.52e-03 2.36e-02
O LINKED GLYCOSYLATION OF MUCINS 40 3.18e-03 1.89e-02 0.39100 2.48e-01 0.303000 6.62e-03 9.28e-04
KERATAN SULFATE DEGRADATION 11 4.24e-02 1.26e-01 0.39100 3.82e-01 0.086200 2.84e-02 6.21e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 4.53e-12 8.89e-10 0.39100 3.20e-01 0.226000 5.61e-13 3.65e-07
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 10 1.68e-01 3.20e-01 0.39100 -1.90e-01 -0.342000 2.99e-01 6.09e-02
CA DEPENDENT EVENTS 36 1.94e-03 1.36e-02 0.39000 1.94e-01 0.339000 4.37e-02 4.40e-04
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 3.92e-03 2.16e-02 0.39000 3.79e-01 0.092900 3.35e-03 4.72e-01
RHOV GTPASE CYCLE 33 3.55e-04 4.02e-03 0.39000 1.24e-01 0.370000 2.19e-01 2.37e-04
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 9.07e-02 2.13e-01 0.38600 2.06e-01 0.327000 1.67e-01 2.85e-02
NCAM1 INTERACTIONS 42 1.08e-03 9.09e-03 0.38400 -1.99e-01 -0.329000 2.57e-02 2.25e-04
TRNA AMINOACYLATION 42 2.37e-03 1.53e-02 0.38400 3.08e-01 0.230000 5.61e-04 1.00e-02
ER TO GOLGI ANTEROGRADE TRANSPORT 142 9.38e-10 7.68e-08 0.38100 3.13e-01 0.217000 1.21e-10 8.11e-06
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 6.61e-04 6.38e-03 0.38000 3.78e-01 -0.041900 6.99e-03 7.65e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 5.95e-02 1.56e-01 0.37800 2.39e-01 0.293000 5.79e-02 2.03e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.04e-02 4.45e-02 0.37700 5.29e-02 0.374000 7.23e-01 1.22e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.52e-03 2.03e-02 0.37700 3.46e-01 0.149000 1.25e-03 1.66e-01
ACYL CHAIN REMODELLING OF PE 17 1.10e-01 2.43e-01 0.37700 2.77e-01 0.255000 4.77e-02 6.88e-02
LYSINE CATABOLISM 11 2.42e-01 4.12e-01 0.37700 2.72e-01 0.261000 1.18e-01 1.35e-01
SULFUR AMINO ACID METABOLISM 23 1.51e-02 5.77e-02 0.37600 3.40e-01 0.162000 4.78e-03 1.79e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 1.92e-01 3.54e-01 0.37400 2.61e-01 0.268000 1.03e-01 9.45e-02
PEROXISOMAL PROTEIN IMPORT 59 4.34e-04 4.52e-03 0.37200 2.91e-01 0.232000 1.12e-04 2.03e-03
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 7.85e-02 1.92e-01 0.37200 3.16e-01 0.197000 2.42e-02 1.60e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 8.44e-04 7.52e-03 0.37200 3.51e-01 0.122000 4.83e-04 2.26e-01
GLUCONEOGENESIS 27 9.79e-03 4.23e-02 0.37100 3.32e-01 0.166000 2.85e-03 1.35e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 8.99e-17 2.65e-14 0.37100 2.92e-01 0.229000 2.59e-17 2.82e-11
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 2.47e-01 4.19e-01 0.37000 -2.39e-01 -0.282000 1.70e-01 1.06e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 1.02e-03 8.67e-03 0.36900 2.01e-01 0.310000 1.60e-02 2.07e-04
G PROTEIN MEDIATED EVENTS 52 8.79e-05 1.29e-03 0.36700 1.51e-01 0.335000 5.95e-02 2.94e-05
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 4.14e-02 1.24e-01 0.36600 3.47e-01 0.117000 1.99e-02 4.34e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 6.07e-02 1.59e-01 0.36600 1.90e-01 0.313000 1.52e-01 1.81e-02
INTERFERON ALPHA BETA SIGNALING 53 2.21e-07 9.28e-06 0.36600 -3.63e-01 -0.047900 4.97e-06 5.46e-01
DARPP 32 EVENTS 23 4.55e-02 1.32e-01 0.36600 2.99e-01 0.211000 1.32e-02 8.01e-02
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 3.93e-02 1.19e-01 0.36400 9.62e-02 0.351000 5.33e-01 2.28e-02
ACTIVATION OF RAC1 13 2.09e-01 3.70e-01 0.36400 2.56e-01 0.259000 1.10e-01 1.06e-01
DNA METHYLATION 23 1.82e-02 6.66e-02 0.36300 -1.51e-01 -0.330000 2.09e-01 6.08e-03
REGULATION OF IFNG SIGNALING 13 2.03e-01 3.64e-01 0.36300 2.34e-01 0.277000 1.44e-01 8.34e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 2.08e-01 3.70e-01 0.36200 2.72e-01 0.240000 8.98e-02 1.35e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.40e-02 5.55e-02 0.36200 2.53e-01 0.259000 8.69e-03 7.25e-03
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.39e-01 4.10e-01 0.36100 2.94e-01 0.209000 9.15e-02 2.30e-01
MHC CLASS II ANTIGEN PRESENTATION 102 3.43e-07 1.35e-05 0.36000 3.11e-01 0.181000 5.56e-08 1.60e-03
INSULIN RECEPTOR RECYCLING 20 3.54e-02 1.12e-01 0.36000 3.25e-01 0.154000 1.18e-02 2.34e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 3.74e-02 1.15e-01 0.35800 2.12e-01 0.289000 6.20e-02 1.08e-02
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 1.57e-01 3.08e-01 0.35800 2.84e-01 0.218000 5.72e-02 1.44e-01
SYNTHESIS OF PA 29 2.93e-02 9.61e-02 0.35700 2.21e-01 0.281000 3.93e-02 8.92e-03
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 1.71e-02 6.40e-02 0.35700 2.26e-01 0.276000 2.26e-02 5.33e-03
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 1.13e-01 2.48e-01 0.35600 2.20e-01 0.280000 1.06e-01 3.99e-02
SIGNALING BY HIPPO 20 4.22e-02 1.25e-01 0.35500 1.57e-01 0.318000 2.23e-01 1.37e-02
PKA MEDIATED PHOSPHORYLATION OF CREB 19 9.56e-02 2.21e-01 0.35500 2.85e-01 0.211000 3.13e-02 1.12e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 2.87e-06 8.45e-05 0.35400 3.12e-01 0.168000 5.80e-07 6.95e-03
PROTEIN METHYLATION 17 7.76e-02 1.91e-01 0.35400 3.13e-01 0.165000 2.56e-02 2.38e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 6.71e-02 1.70e-01 0.35300 1.30e-01 0.329000 3.82e-01 2.76e-02
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.36e-01 2.82e-01 0.35300 2.05e-01 0.287000 1.55e-01 4.65e-02
CHONDROITIN SULFATE BIOSYNTHESIS 18 1.32e-01 2.76e-01 0.35200 2.52e-01 0.246000 6.42e-02 7.09e-02
RHOU GTPASE CYCLE 34 3.10e-04 3.57e-03 0.35100 7.15e-02 0.344000 4.71e-01 5.24e-04
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 4.49e-02 1.31e-01 0.35000 2.45e-01 0.250000 2.50e-02 2.23e-02
CD28 CO STIMULATION 31 1.99e-02 7.08e-02 0.34900 1.94e-01 0.290000 6.19e-02 5.14e-03
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 9.79e-10 7.68e-08 0.34900 2.66e-01 0.227000 4.78e-10 1.10e-07
GAP JUNCTION DEGRADATION 11 2.84e-01 4.57e-01 0.34900 2.70e-01 0.221000 1.21e-01 2.05e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 24 2.75e-02 9.16e-02 0.34800 -1.57e-01 -0.310000 1.82e-01 8.47e-03
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.80e-02 2.07e-01 0.34800 2.14e-01 0.274000 8.93e-02 2.98e-02
NEGATIVE REGULATION OF MET ACTIVITY 20 7.67e-02 1.90e-01 0.34600 1.85e-01 0.293000 1.52e-01 2.35e-02
G1 S SPECIFIC TRANSCRIPTION 26 5.64e-02 1.50e-01 0.34600 2.62e-01 0.226000 2.08e-02 4.66e-02
TELOMERE C STRAND SYNTHESIS INITIATION 13 2.46e-01 4.17e-01 0.34500 2.46e-01 0.241000 1.24e-01 1.32e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.35e-03 1.11e-02 0.34500 3.20e-01 0.129000 5.53e-04 1.64e-01
AUTOPHAGY 138 8.67e-08 4.50e-06 0.34400 2.81e-01 0.199000 1.29e-08 5.68e-05
IRON UPTAKE AND TRANSPORT 51 2.12e-03 1.45e-02 0.34200 2.84e-01 0.191000 4.52e-04 1.82e-02
DEFECTS IN COBALAMIN B12 METABOLISM 13 1.93e-01 3.55e-01 0.34200 1.81e-01 0.290000 2.58e-01 6.98e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 1.70e-01 3.21e-01 0.34200 1.81e-01 0.291000 2.42e-01 5.98e-02
COLLAGEN CHAIN TRIMERIZATION 41 4.88e-03 2.53e-02 0.34200 -1.75e-01 -0.294000 5.28e-02 1.14e-03
CARGO CONCENTRATION IN THE ER 31 1.57e-02 5.96e-02 0.34100 2.97e-01 0.168000 4.20e-03 1.06e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 2.78e-01 4.50e-01 0.34100 2.27e-01 0.254000 1.73e-01 1.27e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 3.12e-01 4.84e-01 0.33900 2.54e-01 0.225000 1.45e-01 1.96e-01
ACTIVATION OF SMO 16 6.61e-02 1.69e-01 0.33900 1.20e-01 0.317000 4.05e-01 2.83e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 1.13e-02 4.77e-02 0.33900 1.10e-01 0.320000 3.41e-01 5.56e-03
BUDDING AND MATURATION OF HIV VIRION 27 5.28e-02 1.45e-01 0.33800 2.65e-01 0.210000 1.71e-02 5.91e-02
AGGREPHAGY 34 1.11e-04 1.56e-03 0.33600 3.35e-01 0.022500 7.26e-04 8.20e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 1.75e-01 3.28e-01 0.33500 2.67e-01 0.202000 6.41e-02 1.62e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 3.26e-01 4.98e-01 0.33500 2.29e-01 0.244000 1.88e-01 1.62e-01
INOSITOL PHOSPHATE METABOLISM 46 1.89e-03 1.35e-02 0.33500 1.54e-01 0.297000 7.14e-02 4.88e-04
FGFR2 LIGAND BINDING AND ACTIVATION 12 2.87e-01 4.60e-01 0.33400 -2.55e-01 -0.216000 1.26e-01 1.95e-01
GLYCOSAMINOGLYCAN METABOLISM 113 8.24e-06 2.06e-04 0.33400 2.55e-01 0.216000 2.76e-06 7.36e-05
INTRAFLAGELLAR TRANSPORT 52 2.95e-06 8.47e-05 0.33400 3.32e-01 0.041000 3.47e-05 6.09e-01
EUKARYOTIC TRANSLATION ELONGATION 87 1.08e-05 2.49e-04 0.33400 -1.59e-01 -0.294000 1.06e-02 2.22e-06
TRANS GOLGI NETWORK VESICLE BUDDING 70 6.22e-04 6.08e-03 0.33300 2.06e-01 0.262000 2.92e-03 1.55e-04
AMINE LIGAND BINDING RECEPTORS 29 4.62e-02 1.33e-01 0.33300 2.04e-01 0.262000 5.69e-02 1.44e-02
COPII MEDIATED VESICLE TRANSPORT 66 7.77e-04 7.09e-03 0.33200 2.68e-01 0.197000 1.69e-04 5.71e-03
SELECTIVE AUTOPHAGY 71 5.70e-05 9.32e-04 0.33200 2.97e-01 0.147000 1.49e-05 3.17e-02
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 1.28e-06 3.98e-05 0.33100 -1.40e-01 -0.300000 1.85e-02 4.23e-07
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 2.57e-02 8.70e-02 0.33000 -1.19e-01 -0.308000 3.25e-01 1.07e-02
PENTOSE PHOSPHATE PATHWAY 13 2.57e-01 4.31e-01 0.32900 2.61e-01 0.200000 1.03e-01 2.11e-01
COMPLEX I BIOGENESIS 56 1.53e-03 1.20e-02 0.32900 -1.75e-01 -0.278000 2.36e-02 3.20e-04
G0 AND EARLY G1 25 8.81e-02 2.07e-01 0.32700 2.37e-01 0.226000 4.06e-02 5.07e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 2.38e-01 4.09e-01 0.32600 1.99e-01 0.259000 1.98e-01 9.40e-02
BIOTIN TRANSPORT AND METABOLISM 11 1.42e-02 5.57e-02 0.32600 -1.05e-01 0.309000 5.48e-01 7.62e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 3.00e-01 4.72e-01 0.32600 1.63e-01 0.282000 3.73e-01 1.22e-01
FORMATION OF APOPTOSOME 10 3.55e-01 5.22e-01 0.32400 2.62e-01 0.190000 1.52e-01 2.98e-01
RAB GERANYLGERANYLATION 57 1.71e-03 1.25e-02 0.32300 2.73e-01 0.173000 3.59e-04 2.42e-02
DISEASES OF DNA REPAIR 11 3.28e-01 5.00e-01 0.32300 1.95e-01 0.257000 2.62e-01 1.39e-01
HSF1 ACTIVATION 25 5.02e-04 5.10e-03 0.32300 3.22e-01 -0.029200 5.37e-03 8.00e-01
VXPX CARGO TARGETING TO CILIUM 19 1.41e-01 2.89e-01 0.32300 1.89e-01 0.261000 1.53e-01 4.88e-02
DAG AND IP3 SIGNALING 40 5.94e-03 2.89e-02 0.32200 1.45e-01 0.287000 1.13e-01 1.67e-03
CONDENSATION OF PROPHASE CHROMOSOMES 30 1.07e-02 4.53e-02 0.32100 -1.15e-01 -0.300000 2.75e-01 4.49e-03
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 2.02e-01 3.64e-01 0.32100 2.16e-01 0.237000 1.23e-01 9.03e-02
MTOR SIGNALLING 40 2.08e-02 7.36e-02 0.32100 2.02e-01 0.249000 2.69e-02 6.47e-03
GABA RECEPTOR ACTIVATION 55 5.67e-03 2.81e-02 0.32100 2.38e-01 0.215000 2.24e-03 5.92e-03
MATURATION OF NUCLEOPROTEIN 10 1.18e-01 2.56e-01 0.32000 -3.16e-01 -0.050100 8.31e-02 7.84e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 13 2.95e-01 4.66e-01 0.32000 -2.38e-01 -0.214000 1.37e-01 1.81e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 29 2.57e-02 8.70e-02 0.32000 -2.85e-01 -0.145000 7.88e-03 1.78e-01
PARASITE INFECTION 54 1.71e-03 1.25e-02 0.32000 1.56e-01 0.279000 4.72e-02 3.95e-04
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 3.66e-01 5.33e-01 0.31900 1.88e-01 0.257000 3.03e-01 1.59e-01
G ALPHA Z SIGNALLING EVENTS 44 8.57e-03 3.82e-02 0.31800 2.69e-01 0.169000 2.04e-03 5.22e-02
SIGNALING BY HEDGEHOG 141 3.89e-07 1.48e-05 0.31700 2.65e-01 0.174000 5.54e-08 3.58e-04
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 84 3.90e-04 4.27e-03 0.31600 2.00e-01 0.244000 1.54e-03 1.09e-04
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 1.92e-03 1.36e-02 0.31500 -7.19e-02 -0.307000 4.68e-01 1.94e-03
PYRUVATE METABOLISM 27 8.88e-02 2.09e-01 0.31400 2.15e-01 0.229000 5.32e-02 3.97e-02
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 1.59e-03 1.23e-02 0.31400 2.62e-01 0.173000 3.30e-04 1.76e-02
SIGNAL AMPLIFICATION 31 3.58e-02 1.12e-01 0.31300 2.67e-01 0.164000 9.97e-03 1.15e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.97e-01 3.61e-01 0.31300 2.60e-01 0.175000 7.17e-02 2.26e-01
PROCESSING AND ACTIVATION OF SUMO 10 3.80e-01 5.42e-01 0.31300 2.53e-01 0.184000 1.66e-01 3.13e-01
PLASMA LIPOPROTEIN CLEARANCE 28 8.17e-02 1.97e-01 0.31300 2.32e-01 0.210000 3.39e-02 5.43e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 2.03e-04 2.57e-03 0.31200 2.47e-01 0.190000 4.59e-05 1.72e-03
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 5.71e-02 1.51e-01 0.31200 1.49e-01 0.274000 1.96e-01 1.78e-02
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 3.02e-04 3.52e-03 0.31200 1.94e-01 0.244000 1.71e-03 7.53e-05
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.67e-01 3.19e-01 0.31100 -2.98e-01 -0.087600 8.69e-02 6.15e-01
METABOLISM OF CARBOHYDRATES 260 9.48e-11 1.24e-08 0.31000 2.38e-01 0.199000 4.21e-11 3.17e-08
SYNTHESIS OF PE 13 2.96e-01 4.67e-01 0.31000 1.87e-01 0.248000 2.44e-01 1.22e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 1.23e-01 2.65e-01 0.31000 2.23e-01 0.215000 5.83e-02 6.85e-02
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 108 7.45e-05 1.14e-03 0.30900 2.03e-01 0.234000 2.72e-04 2.76e-05
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.90e-02 1.92e-01 0.30900 1.93e-01 0.241000 7.69e-02 2.70e-02
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 3.54e-03 2.03e-02 0.30900 1.64e-01 0.262000 3.54e-02 7.86e-04
PI METABOLISM 79 4.35e-05 7.58e-04 0.30800 1.25e-01 0.281000 5.40e-02 1.53e-05
PKMTS METHYLATE HISTONE LYSINES 51 2.97e-03 1.79e-02 0.30800 -2.73e-01 -0.144000 7.63e-04 7.62e-02
HSF1 DEPENDENT TRANSACTIVATION 33 9.22e-04 7.98e-03 0.30700 3.06e-01 0.033100 2.38e-03 7.43e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 1.49e-01 2.98e-01 0.30700 1.76e-01 0.252000 1.72e-01 5.15e-02
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 4.74e-02 1.34e-01 0.30600 2.19e-01 0.214000 2.33e-02 2.65e-02
MTORC1 MEDIATED SIGNALLING 24 1.30e-01 2.73e-01 0.30600 2.09e-01 0.223000 7.65e-02 5.86e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.09e-01 5.71e-01 0.30600 2.41e-01 0.188000 1.87e-01 3.03e-01
PHOSPHOLIPID METABOLISM 186 1.96e-08 1.15e-06 0.30500 1.70e-01 0.253000 6.53e-05 2.59e-09
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 7.74e-02 1.91e-01 0.30400 1.42e-01 0.269000 2.37e-01 2.55e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 5.13e-03 2.60e-02 0.30400 2.88e-01 0.096400 2.74e-03 3.17e-01
MEMBRANE TRAFFICKING 581 1.17e-21 6.90e-19 0.30400 1.98e-01 0.230000 3.53e-16 3.07e-21
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 2.40e-01 4.11e-01 0.30200 2.52e-01 0.167000 9.12e-02 2.62e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 8.82e-03 3.89e-02 0.30200 2.81e-01 0.111000 3.55e-03 2.47e-01
PRE NOTCH PROCESSING IN GOLGI 18 1.69e-01 3.21e-01 0.30200 1.59e-01 0.257000 2.41e-01 5.95e-02
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 8.09e-02 1.96e-01 0.30200 2.26e-01 0.200000 3.22e-02 5.74e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 4.73e-02 1.34e-01 0.30200 2.89e-01 0.086100 2.52e-02 5.05e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 23 1.34e-01 2.80e-01 0.30100 1.84e-01 0.239000 1.27e-01 4.77e-02
SARS COV 2 INFECTION 65 4.84e-03 2.52e-02 0.30100 2.15e-01 0.211000 2.77e-03 3.26e-03
TBC RABGAPS 43 2.47e-02 8.45e-02 0.30100 1.87e-01 0.236000 3.42e-02 7.46e-03
PRC2 METHYLATES HISTONES AND DNA 32 4.57e-02 1.32e-01 0.30100 -1.61e-01 -0.254000 1.15e-01 1.30e-02
SEROTONIN RECEPTORS 10 3.58e-01 5.26e-01 0.29900 2.60e-01 0.148000 1.54e-01 4.18e-01
REGULATION OF KIT SIGNALING 16 2.68e-01 4.40e-01 0.29800 1.95e-01 0.226000 1.77e-01 1.18e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 4.10e-02 1.24e-01 0.29800 3.76e-03 0.298000 9.81e-01 5.33e-02
CLATHRIN MEDIATED ENDOCYTOSIS 133 1.77e-05 3.59e-04 0.29800 1.93e-01 0.228000 1.27e-04 5.83e-06
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.91e-02 6.89e-02 0.29800 2.27e-01 0.193000 6.45e-03 2.10e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.96e-01 3.59e-01 0.29700 1.94e-01 0.225000 1.33e-01 8.19e-02
INTEGRATION OF ENERGY METABOLISM 100 2.94e-04 3.49e-03 0.29700 2.25e-01 0.193000 9.86e-05 8.55e-04
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 4.29e-04 4.51e-03 0.29600 -1.33e-02 0.296000 8.96e-01 3.74e-03
VEGFR2 MEDIATED CELL PROLIFERATION 19 2.19e-01 3.85e-01 0.29600 2.15e-01 0.204000 1.04e-01 1.25e-01
INTERFERON GAMMA SIGNALING 73 1.04e-06 3.39e-05 0.29600 -2.94e-01 -0.039500 1.45e-05 5.60e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 2.89e-01 4.62e-01 0.29600 -2.52e-01 -0.155000 1.15e-01 3.33e-01
NUCLEOTIDE SALVAGE 21 1.09e-01 2.41e-01 0.29600 2.62e-01 0.138000 3.77e-02 2.74e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 2.12e-04 2.63e-03 0.29600 1.84e-01 0.232000 1.36e-03 5.23e-05
UNFOLDED PROTEIN RESPONSE UPR 85 8.54e-04 7.56e-03 0.29500 2.32e-01 0.182000 2.13e-04 3.66e-03
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 5.10e-02 1.41e-01 0.29500 -2.37e-01 -0.176000 1.54e-02 7.11e-02
RHOG GTPASE CYCLE 74 5.63e-05 9.32e-04 0.29500 9.94e-02 0.277000 1.39e-01 3.71e-05
HDACS DEACETYLATE HISTONES 49 2.13e-02 7.52e-02 0.29400 -2.07e-01 -0.210000 1.24e-02 1.11e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 7.53e-02 1.88e-01 0.29400 2.56e-01 0.144000 2.39e-02 2.03e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 58 3.12e-04 3.57e-03 0.29400 2.80e-01 0.089900 2.30e-04 2.36e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 9.30e-03 4.07e-02 0.29200 -2.90e-01 -0.035200 1.22e-02 7.61e-01
HDMS DEMETHYLATE HISTONES 30 4.30e-03 2.32e-02 0.29100 -2.88e-01 -0.039900 6.27e-03 7.05e-01
RHOBTB2 GTPASE CYCLE 23 1.27e-01 2.70e-01 0.29100 2.45e-01 0.157000 4.23e-02 1.91e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 5.57e-02 1.50e-01 0.29000 2.58e-01 0.132000 1.81e-02 2.27e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 3.80e-02 1.17e-01 0.29000 1.28e-01 0.260000 2.17e-01 1.23e-02
RHOJ GTPASE CYCLE 54 7.52e-04 6.96e-03 0.29000 9.11e-02 0.275000 2.47e-01 4.77e-04
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 3.90e-02 1.19e-01 0.28900 6.67e-02 0.282000 5.97e-01 2.55e-02
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 3.40e-03 1.98e-02 0.28800 1.91e-01 0.215000 4.21e-03 1.29e-03
DEADENYLATION OF MRNA 25 1.01e-01 2.29e-01 0.28800 1.48e-01 0.247000 2.01e-01 3.28e-02
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 3.54e-01 5.22e-01 0.28700 2.40e-01 0.158000 1.50e-01 3.44e-01
RHOB GTPASE CYCLE 67 1.13e-06 3.59e-05 0.28700 1.06e-02 0.287000 8.81e-01 4.84e-05
MITOPHAGY 29 6.22e-02 1.61e-01 0.28700 2.51e-01 0.140000 1.93e-02 1.92e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 8.86e-04 7.73e-03 0.28700 1.55e-01 0.241000 1.60e-02 1.78e-04
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 3.04e-01 4.77e-01 0.28600 -2.01e-01 -0.204000 1.63e-01 1.59e-01
PROTEIN LOCALIZATION 158 1.02e-06 3.39e-05 0.28500 2.42e-01 0.151000 1.53e-07 1.10e-03
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 182 1.64e-06 4.94e-05 0.28500 1.94e-01 0.209000 6.69e-06 1.24e-06
FATTY ACID METABOLISM 146 2.27e-05 4.46e-04 0.28400 1.92e-01 0.209000 6.05e-05 1.30e-05
PROLACTIN RECEPTOR SIGNALING 11 3.77e-01 5.41e-01 0.28400 2.43e-01 0.148000 1.63e-01 3.97e-01
HS GAG BIOSYNTHESIS 30 1.09e-01 2.41e-01 0.28400 2.11e-01 0.190000 4.55e-02 7.17e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.30e-01 5.02e-01 0.28400 2.61e-01 0.111000 1.53e-01 5.42e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 50 2.58e-02 8.70e-02 0.28300 -1.90e-01 -0.209000 1.99e-02 1.04e-02
FCGR3A MEDIATED IL10 SYNTHESIS 32 9.27e-02 2.17e-01 0.28300 1.83e-01 0.216000 7.31e-02 3.48e-02
CHOLESTEROL BIOSYNTHESIS 24 4.21e-02 1.25e-01 0.28300 2.70e-01 0.083300 2.19e-02 4.80e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 3.78e-01 5.42e-01 0.28200 -2.51e-01 -0.129000 1.70e-01 4.82e-01
GABA B RECEPTOR ACTIVATION 40 5.63e-02 1.50e-01 0.28200 2.03e-01 0.195000 2.61e-02 3.31e-02
SIALIC ACID METABOLISM 32 9.57e-02 2.21e-01 0.28100 2.14e-01 0.183000 3.63e-02 7.38e-02
THE PHOTOTRANSDUCTION CASCADE 22 4.13e-02 1.24e-01 0.28100 -6.55e-02 -0.273000 5.95e-01 2.65e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.76e-01 4.49e-01 0.28100 -2.22e-01 -0.172000 1.13e-01 2.19e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.80e-01 4.52e-01 0.27900 -2.30e-01 -0.158000 1.11e-01 2.73e-01
OPIOID SIGNALLING 87 1.17e-03 9.73e-03 0.27900 1.62e-01 0.227000 8.94e-03 2.51e-04
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 15 2.12e-01 3.76e-01 0.27900 -1.15e-01 -0.254000 4.39e-01 8.85e-02
NONSENSE MEDIATED DECAY NMD 109 6.96e-05 1.11e-03 0.27800 -1.38e-01 -0.241000 1.28e-02 1.35e-05
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 4.55e-01 6.20e-01 0.27700 1.79e-01 0.212000 3.04e-01 2.24e-01
RESOLUTION OF D LOOP STRUCTURES 31 1.17e-02 4.80e-02 0.27700 -2.70e-01 -0.061800 9.21e-03 5.52e-01
HEDGEHOG OFF STATE 106 5.62e-06 1.46e-04 0.27700 2.59e-01 0.096600 3.97e-06 8.60e-02
BLOOD GROUP SYSTEMS BIOSYNTHESIS 15 3.28e-01 5.00e-01 0.27600 1.65e-01 0.221000 2.67e-01 1.38e-01
NEPHRIN FAMILY INTERACTIONS 23 5.58e-02 1.50e-01 0.27600 8.14e-02 0.264000 4.99e-01 2.86e-02
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 15 1.37e-01 2.82e-01 0.27600 7.26e-02 0.266000 6.26e-01 7.44e-02
NUCLEAR IMPORT OF REV PROTEIN 32 1.98e-03 1.38e-02 0.27500 2.53e-03 0.275000 9.80e-01 7.11e-03
TIGHT JUNCTION INTERACTIONS 16 3.11e-01 4.82e-01 0.27400 1.66e-01 0.219000 2.51e-01 1.30e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 4.90e-03 2.53e-02 0.27400 1.10e-01 0.252000 1.71e-01 1.71e-03
VESICLE MEDIATED TRANSPORT 613 1.93e-18 7.57e-16 0.27400 1.85e-01 0.202000 5.33e-15 1.55e-17
LAMININ INTERACTIONS 29 3.30e-02 1.06e-01 0.27400 -2.59e-01 -0.088400 1.57e-02 4.10e-01
RAC2 GTPASE CYCLE 87 8.69e-05 1.29e-03 0.27300 1.00e-01 0.254000 1.07e-01 4.23e-05
SYNTHESIS OF PC 26 1.69e-01 3.21e-01 0.27200 2.05e-01 0.180000 7.08e-02 1.13e-01
UNWINDING OF DNA 12 3.68e-01 5.35e-01 0.27200 1.38e-01 0.235000 4.09e-01 1.59e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 1.50e-01 2.98e-01 0.27200 1.25e-01 0.242000 3.23e-01 5.52e-02
INTEGRIN CELL SURFACE INTERACTIONS 75 6.05e-03 2.91e-02 0.27200 -2.06e-01 -0.177000 2.04e-03 8.12e-03
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 5.33e-02 1.46e-01 0.27100 1.24e-01 -0.241000 4.99e-01 1.86e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 1.46e-01 2.95e-01 0.27100 2.67e-01 0.048200 9.58e-02 7.63e-01
PEPTIDE HORMONE METABOLISM 60 1.84e-02 6.73e-02 0.27000 1.99e-01 0.183000 7.79e-03 1.40e-02
SCAVENGING BY CLASS A RECEPTORS 14 2.27e-02 7.92e-02 0.27000 9.29e-02 -0.254000 5.48e-01 1.00e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 3.85e-03 2.16e-02 0.27000 3.40e-02 0.268000 7.28e-01 6.11e-03
RAB REGULATION OF TRAFFICKING 119 1.57e-04 2.07e-03 0.27000 1.53e-01 0.222000 3.88e-03 2.91e-05
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 2.56e-01 4.29e-01 0.27000 -1.59e-01 -0.218000 2.31e-01 1.00e-01
ATTENUATION PHASE 23 1.40e-03 1.12e-02 0.26900 2.43e-01 -0.117000 4.40e-02 3.31e-01
METABOLISM OF NUCLEOTIDES 92 9.72e-04 8.29e-03 0.26900 2.25e-01 0.148000 1.96e-04 1.39e-02
FORMATION OF THE CORNIFIED ENVELOPE 31 1.11e-04 1.56e-03 0.26900 1.33e-01 -0.233000 1.99e-01 2.46e-02
TRANSMISSION ACROSS CHEMICAL SYNAPSES 243 1.01e-07 4.75e-06 0.26900 1.74e-01 0.205000 3.13e-06 3.92e-08
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 9.15e-07 3.17e-05 0.26900 2.67e-01 -0.025300 1.72e-04 7.22e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 3.42e-01 5.12e-01 0.26800 2.40e-01 0.120000 1.51e-01 4.70e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 7.27e-02 1.82e-01 0.26800 9.00e-05 0.268000 1.00e+00 8.25e-02
CELLULAR RESPONSE TO HEAT STRESS 94 2.17e-03 1.46e-02 0.26800 1.97e-01 0.181000 9.47e-04 2.42e-03
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 2.34e-02 8.09e-02 0.26800 2.19e-01 0.153000 6.25e-03 5.57e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 27 9.30e-02 2.17e-01 0.26800 -1.22e-01 -0.238000 2.74e-01 3.21e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 8.42e-02 2.01e-01 0.26700 2.58e-01 0.071300 4.61e-02 5.81e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.14e-02 4.77e-02 0.26600 2.65e-01 0.027700 1.53e-02 7.99e-01
SARS COV 1 INFECTION 48 4.27e-02 1.26e-01 0.26600 1.73e-01 0.203000 3.83e-02 1.52e-02
EPHB MEDIATED FORWARD SIGNALING 42 6.47e-02 1.66e-01 0.26600 1.75e-01 0.200000 4.91e-02 2.49e-02
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 2.77e-01 4.50e-01 0.26600 -1.03e-01 -0.245000 5.20e-01 1.26e-01
SIGNALING BY WNT IN CANCER 31 6.40e-02 1.65e-01 0.26600 1.18e-01 0.238000 2.54e-01 2.16e-02
CELLULAR HEXOSE TRANSPORT 12 1.58e-01 3.09e-01 0.26600 3.46e-02 0.264000 8.36e-01 1.14e-01
PROTEIN UBIQUITINATION 70 7.74e-03 3.50e-02 0.26500 2.14e-01 0.156000 1.92e-03 2.37e-02
MITOTIC TELOPHASE CYTOKINESIS 13 2.79e-02 9.24e-02 0.26500 -1.13e-01 0.240000 4.81e-01 1.34e-01
SIGNAL TRANSDUCTION BY L1 21 2.25e-01 3.91e-01 0.26500 2.17e-01 0.151000 8.46e-02 2.31e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 2.99e-02 9.70e-02 0.26400 -1.43e-02 0.264000 9.17e-01 5.25e-02
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 1.22e-04 1.69e-03 0.26400 -7.15e-02 0.254000 4.52e-01 7.43e-03
TRIGLYCERIDE CATABOLISM 14 3.05e-01 4.77e-01 0.26400 2.34e-01 0.122000 1.29e-01 4.29e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 2.94e-02 9.62e-02 0.26400 2.53e-01 0.074500 1.63e-02 4.80e-01
HEDGEHOG LIGAND BIOGENESIS 61 2.75e-03 1.71e-02 0.26400 2.43e-01 0.102000 1.02e-03 1.67e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 1.38e-03 1.12e-02 0.26300 2.28e-01 0.132000 3.04e-04 3.71e-02
ERYTHROPOIETIN ACTIVATES RAS 13 4.35e-01 5.98e-01 0.26300 1.99e-01 0.172000 2.14e-01 2.83e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 72 6.06e-03 2.91e-02 0.26200 2.18e-01 0.145000 1.40e-03 3.36e-02
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.68e-02 2.21e-01 0.26100 1.29e-02 0.261000 9.33e-01 9.07e-02
FCERI MEDIATED MAPK ACTIVATION 28 1.73e-01 3.27e-01 0.26100 1.74e-01 0.195000 1.10e-01 7.48e-02
EXTRA NUCLEAR ESTROGEN SIGNALING 68 4.94e-03 2.53e-02 0.26100 2.27e-01 0.129000 1.20e-03 6.59e-02
RNA POLYMERASE III CHAIN ELONGATION 18 6.11e-02 1.60e-01 0.26100 -2.51e-02 -0.260000 8.54e-01 5.65e-02
RMTS METHYLATE HISTONE ARGININES 46 3.09e-02 9.99e-02 0.26000 -1.33e-01 -0.224000 1.20e-01 8.57e-03
ERK MAPK TARGETS 22 4.75e-02 1.34e-01 0.26000 4.33e-02 0.256000 7.25e-01 3.73e-02
RESPIRATORY ELECTRON TRANSPORT 102 2.89e-04 3.47e-03 0.25900 -1.22e-01 -0.229000 3.38e-02 6.67e-05
INTERLEUKIN 10 SIGNALING 19 2.69e-01 4.42e-01 0.25900 -2.15e-01 -0.145000 1.05e-01 2.74e-01
METABOLISM OF POLYAMINES 57 2.23e-03 1.49e-02 0.25800 2.46e-01 0.079700 1.34e-03 2.98e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 7.84e-02 1.92e-01 0.25800 6.80e-02 -0.249000 6.96e-01 1.53e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 1.43e-01 2.91e-01 0.25800 -2.40e-02 0.257000 8.95e-01 1.59e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 17 2.33e-01 4.02e-01 0.25700 -2.33e-01 -0.110000 9.66e-02 4.33e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 4.87e-01 6.47e-01 0.25700 -1.82e-01 -0.181000 2.74e-01 2.77e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 1.67e-01 3.19e-01 0.25700 2.35e-01 0.103000 6.86e-02 4.27e-01
REGULATION OF INSULIN SECRETION 72 1.07e-02 4.55e-02 0.25600 2.03e-01 0.157000 2.96e-03 2.11e-02
PROTEIN FOLDING 90 1.33e-05 2.89e-04 0.25600 2.50e-01 0.053500 4.07e-05 3.80e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 5.69e-02 1.50e-01 0.25500 -2.43e-01 -0.077000 2.86e-02 4.89e-01
SIGNALLING TO ERKS 33 1.13e-01 2.47e-01 0.25400 1.43e-01 0.210000 1.55e-01 3.69e-02
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 9.68e-02 2.21e-01 0.25400 2.30e-01 0.108000 3.56e-02 3.22e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 24 1.97e-01 3.60e-01 0.25400 2.13e-01 0.138000 7.14e-02 2.41e-01
MITOTIC METAPHASE AND ANAPHASE 207 5.71e-06 1.46e-04 0.25100 1.93e-01 0.161000 1.77e-06 6.73e-05
METABOLISM OF LIPIDS 616 1.64e-16 3.86e-14 0.25100 1.52e-01 0.200000 1.47e-10 3.14e-17
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 3.91e-02 1.19e-01 0.25000 1.36e-01 0.210000 1.00e-01 1.09e-02
AMINO ACIDS REGULATE MTORC1 51 5.38e-02 1.47e-01 0.25000 1.86e-01 0.167000 2.14e-02 3.91e-02
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 101 5.07e-04 5.10e-03 0.25000 1.15e-01 0.221000 4.50e-02 1.23e-04
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 3.33e-03 1.96e-02 0.24900 2.32e-01 0.090100 1.42e-03 2.16e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 4.10e-01 5.72e-01 0.24900 1.53e-01 0.196000 3.04e-01 1.88e-01
GPVI MEDIATED ACTIVATION CASCADE 31 1.32e-01 2.76e-01 0.24700 1.32e-01 0.209000 2.02e-01 4.43e-02
RHOC GTPASE CYCLE 73 1.68e-04 2.20e-03 0.24700 4.80e-02 0.242000 4.79e-01 3.48e-04
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 4.15e-01 5.78e-01 0.24600 9.01e-02 0.229000 6.22e-01 2.09e-01
HEME BIOSYNTHESIS 13 3.32e-01 5.04e-01 0.24600 9.46e-02 0.227000 5.55e-01 1.56e-01
TRIGLYCERIDE BIOSYNTHESIS 10 1.37e-01 2.82e-01 0.24600 -5.03e-02 0.241000 7.83e-01 1.87e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 12 3.48e-01 5.15e-01 0.24600 2.29e-01 0.089100 1.70e-01 5.93e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 2.62e-01 4.33e-01 0.24400 9.38e-02 0.226000 5.16e-01 1.18e-01
ABC TRANSPORTER DISORDERS 69 1.89e-03 1.35e-02 0.24400 2.30e-01 0.082300 9.60e-04 2.38e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 5.90e-03 2.88e-02 0.24300 3.13e-03 0.243000 9.75e-01 1.43e-02
RHO GTPASES ACTIVATE NADPH OXIDASES 20 3.13e-01 4.84e-01 0.24300 1.43e-01 0.196000 2.67e-01 1.29e-01
CGMP EFFECTS 15 3.80e-01 5.42e-01 0.24200 -2.07e-01 -0.126000 1.65e-01 3.98e-01
KERATINIZATION 32 4.93e-04 5.05e-03 0.24200 1.19e-01 -0.211000 2.45e-01 3.88e-02
RND2 GTPASE CYCLE 39 6.94e-03 3.22e-02 0.24200 3.10e-02 0.240000 7.38e-01 9.45e-03
BILE ACID AND BILE SALT METABOLISM 26 1.56e-01 3.07e-01 0.24200 1.11e-01 0.215000 3.27e-01 5.77e-02
INTERLEUKIN 6 SIGNALING 10 5.61e-01 7.05e-01 0.24200 1.43e-01 0.195000 4.34e-01 2.85e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 7.57e-03 3.44e-02 0.24100 1.71e-01 0.170000 4.42e-03 4.60e-03
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 3.12e-01 4.84e-01 0.24100 1.64e-01 0.177000 1.83e-01 1.52e-01
NUCLEOBASE CATABOLISM 31 1.86e-01 3.47e-01 0.24000 1.86e-01 0.153000 7.38e-02 1.41e-01
RHO GTPASES ACTIVATE FORMINS 119 1.89e-03 1.35e-02 0.24000 1.59e-01 0.180000 2.70e-03 7.17e-04
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 3.16e-03 1.89e-02 0.24000 -4.44e-02 0.236000 6.69e-01 2.30e-02
PLATELET ACTIVATION SIGNALING AND AGGREGATION 224 9.21e-06 2.21e-04 0.24000 1.63e-01 0.176000 2.79e-05 5.86e-06
RHOBTB1 GTPASE CYCLE 23 1.95e-01 3.58e-01 0.23900 1.06e-01 0.214000 3.78e-01 7.63e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.96e-01 5.59e-01 0.23800 9.56e-02 0.218000 5.66e-01 1.90e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 4.62e-03 2.43e-02 0.23800 -4.73e-02 0.234000 6.59e-01 2.95e-02
SIGNALING BY NODAL 15 9.67e-02 2.21e-01 0.23800 -2.38e-01 0.010100 1.11e-01 9.46e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 2.59e-01 4.32e-01 0.23800 1.18e-01 0.206000 3.48e-01 1.02e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 6.82e-02 1.72e-01 0.23800 2.11e-01 0.109000 2.25e-02 2.39e-01
RHOQ GTPASE CYCLE 57 4.18e-04 4.44e-03 0.23800 1.29e-02 0.237000 8.66e-01 1.95e-03
INHIBITION OF DNA RECOMBINATION AT TELOMERE 38 1.86e-02 6.76e-02 0.23600 -5.14e-02 -0.230000 5.83e-01 1.40e-02
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 2.18e-02 7.61e-02 0.23600 1.71e-01 0.162000 9.94e-03 1.46e-02
EGFR DOWNREGULATION 28 2.42e-01 4.12e-01 0.23600 1.74e-01 0.159000 1.11e-01 1.46e-01
GLUCOSE METABOLISM 81 1.73e-02 6.41e-02 0.23500 1.67e-01 0.166000 9.49e-03 9.72e-03
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 25 3.62e-02 1.13e-01 0.23500 -1.42e-02 -0.235000 9.02e-01 4.22e-02
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 2.23e-01 3.89e-01 0.23400 9.96e-02 0.212000 4.30e-01 9.22e-02
RHOD GTPASE CYCLE 51 1.44e-02 5.60e-02 0.23400 8.00e-02 0.220000 3.23e-01 6.49e-03
HIV ELONGATION ARREST AND RECOVERY 32 8.75e-02 2.07e-01 0.23400 -9.08e-02 -0.216000 3.74e-01 3.47e-02
NEUTROPHIL DEGRANULATION 386 9.17e-10 7.68e-08 0.23400 1.91e-01 0.135000 1.23e-10 5.72e-06
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.04e-01 3.65e-01 0.23400 -7.15e-02 -0.223000 5.99e-01 1.02e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 4.59e-03 2.43e-02 0.23400 1.77e-01 0.152000 1.53e-03 6.67e-03
NRAGE SIGNALS DEATH THROUGH JNK 54 1.03e-04 1.50e-03 0.23400 -3.59e-02 0.231000 6.48e-01 3.36e-03
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 9.82e-02 2.24e-01 0.23300 2.23e-01 0.069600 4.93e-02 5.39e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 3.42e-01 5.12e-01 0.23300 1.99e-01 0.122000 1.44e-01 3.72e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 3.69e-01 5.35e-01 0.23300 1.74e-01 0.155000 1.77e-01 2.32e-01
MITOTIC SPINDLE CHECKPOINT 97 3.24e-03 1.92e-02 0.23300 1.21e-01 0.199000 3.95e-02 7.23e-04
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 3.14e-02 1.01e-01 0.23300 5.08e-02 0.227000 6.08e-01 2.20e-02
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 3.37e-01 5.10e-01 0.23200 1.54e-01 0.174000 2.12e-01 1.58e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.71e-02 1.34e-01 0.23200 1.32e-01 0.191000 8.85e-02 1.36e-02
SUMOYLATION OF SUMOYLATION PROTEINS 33 6.04e-03 2.91e-02 0.23200 -1.92e-02 0.231000 8.49e-01 2.17e-02
PLATELET CALCIUM HOMEOSTASIS 26 5.72e-03 2.81e-02 0.23200 -7.99e-02 0.217000 4.81e-01 5.51e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 3.16e-01 4.87e-01 0.23100 1.86e-01 0.138000 1.31e-01 2.63e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 2.68e-02 8.95e-02 0.23100 7.37e-02 0.219000 4.03e-01 1.30e-02
GP1B IX V ACTIVATION SIGNALLING 11 5.81e-01 7.21e-01 0.23100 -1.50e-01 -0.175000 3.90e-01 3.14e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.22e-01 4.94e-01 0.23000 -1.94e-01 -0.122000 1.33e-01 3.44e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 2.42e-01 4.12e-01 0.22900 1.27e-01 0.191000 2.63e-01 9.20e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 3.71e-01 5.35e-01 0.22900 1.09e-01 0.201000 4.50e-01 1.63e-01
INTERLEUKIN 17 SIGNALING 68 8.00e-03 3.58e-02 0.22900 9.13e-02 0.210000 1.93e-01 2.81e-03
NEDDYLATION 217 1.43e-05 3.01e-04 0.22900 1.85e-01 0.134000 2.55e-06 7.08e-04
TNF SIGNALING 43 1.20e-01 2.59e-01 0.22800 1.43e-01 0.178000 1.05e-01 4.35e-02
SIGNALING BY NTRKS 129 1.49e-03 1.18e-02 0.22800 1.37e-01 0.183000 7.38e-03 3.45e-04
METABOLISM OF COFACTORS 19 2.65e-02 8.89e-02 0.22800 7.66e-02 -0.214000 5.63e-01 1.06e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 1.54e-01 3.04e-01 0.22800 -1.13e-02 0.227000 9.44e-01 1.56e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 83 2.71e-04 3.29e-03 0.22800 4.71e-02 0.223000 4.58e-01 4.57e-04
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 9.64e-02 2.21e-01 0.22700 2.02e-01 0.103000 3.34e-02 2.77e-01
RHOA GTPASE CYCLE 141 5.43e-06 1.46e-04 0.22700 6.43e-02 0.218000 1.87e-01 8.33e-06
MUCOPOLYSACCHARIDOSES 11 5.98e-01 7.32e-01 0.22700 1.58e-01 0.162000 3.63e-01 3.51e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 4.67e-01 6.28e-01 0.22700 1.34e-01 0.183000 3.70e-01 2.19e-01
REGULATION OF SIGNALING BY CBL 22 1.36e-01 2.82e-01 0.22700 5.80e-02 0.219000 6.38e-01 7.53e-02
SIGNALING BY FGFR3 34 1.99e-01 3.62e-01 0.22600 1.72e-01 0.147000 8.23e-02 1.38e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 2.35e-01 4.05e-01 0.22600 9.20e-02 0.207000 4.66e-01 1.01e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1225 8.09e-24 9.52e-21 0.22600 1.64e-01 0.156000 7.84e-22 8.49e-20
NUCLEAR ENVELOPE BREAKDOWN 49 1.01e-02 4.32e-02 0.22600 5.23e-02 0.220000 5.27e-01 7.78e-03
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 51 5.01e-02 1.39e-01 0.22500 -1.97e-01 -0.109000 1.52e-02 1.77e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.26e-01 2.69e-01 0.22500 -2.03e-01 -0.097200 4.71e-02 3.42e-01
PROCESSING OF SMDT1 16 3.33e-01 5.05e-01 0.22400 2.06e-01 0.089400 1.54e-01 5.36e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 5.56e-03 2.77e-02 0.22400 2.12e-01 0.072300 2.87e-03 3.10e-01
SIGNALING BY RETINOIC ACID 33 2.00e-01 3.62e-01 0.22400 1.35e-01 0.179000 1.80e-01 7.54e-02
SIGNALING BY VEGF 103 5.29e-03 2.67e-02 0.22400 1.27e-01 0.185000 2.62e-02 1.22e-03
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.86e-01 7.22e-01 0.22400 1.19e-01 0.189000 5.13e-01 3.01e-01
SEPARATION OF SISTER CHROMATIDS 166 4.73e-04 4.88e-03 0.22300 1.71e-01 0.143000 1.40e-04 1.55e-03
PECAM1 INTERACTIONS 12 2.15e-01 3.79e-01 0.22300 1.69e-03 0.223000 9.92e-01 1.82e-01
BASE EXCISION REPAIR AP SITE FORMATION 32 1.02e-01 2.29e-01 0.22300 -8.21e-02 -0.207000 4.22e-01 4.28e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 7.61e-02 1.89e-01 0.22200 2.88e-02 0.221000 8.07e-01 6.15e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 6.67e-03 3.13e-02 0.22200 2.21e-01 0.026200 9.63e-03 7.59e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.32e-01 2.76e-01 0.22200 -2.19e-01 0.037000 1.72e-01 8.17e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 5.58e-02 1.50e-01 0.22200 1.73e-01 0.138000 1.84e-02 5.94e-02
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 2.40e-01 4.11e-01 0.22200 -2.17e-01 -0.044300 1.46e-01 7.66e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 8.63e-02 2.05e-01 0.22100 2.16e-01 -0.048400 1.47e-01 7.46e-01
ACYL CHAIN REMODELLING OF PC 17 4.56e-01 6.20e-01 0.22100 1.72e-01 0.140000 2.20e-01 3.19e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.18e-01 3.83e-01 0.22100 1.87e-01 0.118000 8.12e-02 2.72e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.30e-01 2.73e-01 0.22100 -5.92e-02 0.213000 7.23e-01 2.01e-01
INTEGRIN SIGNALING 24 1.98e-01 3.62e-01 0.22100 8.66e-02 0.203000 4.63e-01 8.47e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 4.07e-01 5.70e-01 0.22100 1.82e-01 0.125000 1.81e-01 3.60e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 2.43e-02 8.35e-02 0.22100 4.93e-02 0.215000 5.85e-01 1.73e-02
G ALPHA Q SIGNALLING EVENTS 153 6.06e-04 6.05e-03 0.22100 1.80e-01 0.127000 1.24e-04 6.54e-03
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 4.13e-04 4.42e-03 0.22000 -9.42e-02 -0.199000 6.91e-02 1.22e-04
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 3.42e-03 1.98e-02 0.22000 2.07e-01 0.076000 1.60e-03 2.46e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.54e-01 3.04e-01 0.22000 1.66e-01 0.145000 6.34e-02 1.04e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 64 6.65e-03 3.13e-02 0.22000 -2.09e-01 -0.066300 3.78e-03 3.59e-01
SIGNALING BY NTRK2 TRKB 24 2.15e-01 3.78e-01 0.22000 9.05e-02 0.200000 4.43e-01 8.98e-02
HYALURONAN METABOLISM 15 5.17e-01 6.72e-01 0.21900 1.48e-01 0.162000 3.20e-01 2.78e-01
COSTIMULATION BY THE CD28 FAMILY 50 6.71e-02 1.70e-01 0.21900 1.11e-01 0.189000 1.75e-01 2.06e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 1.42e-02 5.57e-02 0.21900 -2.17e-01 -0.028500 1.62e-02 7.53e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.57e-01 6.20e-01 0.21900 1.54e-01 0.156000 2.59e-01 2.53e-01
HOST INTERACTIONS OF HIV FACTORS 125 4.47e-03 2.38e-02 0.21900 1.58e-01 0.151000 2.23e-03 3.57e-03
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 4.00e-01 5.63e-01 0.21800 6.76e-02 0.207000 6.85e-01 2.14e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 8.60e-02 2.05e-01 0.21800 -1.53e-01 0.155000 3.59e-01 3.52e-01
METABOLISM OF STEROIDS 116 6.52e-03 3.09e-02 0.21700 1.40e-01 0.165000 9.06e-03 2.14e-03
MYD88 INDEPENDENT TLR4 CASCADE 93 1.09e-02 4.60e-02 0.21700 1.20e-01 0.180000 4.61e-02 2.65e-03
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.54e-01 3.04e-01 0.21600 1.57e-01 0.149000 7.23e-02 8.65e-02
SIGNALING BY BMP 25 1.45e-01 2.93e-01 0.21600 6.35e-02 0.207000 5.83e-01 7.36e-02
PI 3K CASCADE FGFR2 17 1.90e-01 3.53e-01 0.21600 -2.13e-01 -0.033000 1.28e-01 8.14e-01
HEDGEHOG ON STATE 82 1.88e-02 6.81e-02 0.21600 1.80e-01 0.119000 4.81e-03 6.28e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 3.79e-01 5.42e-01 0.21600 -2.13e-01 -0.033200 2.44e-01 8.56e-01
SLC TRANSPORTER DISORDERS 75 8.72e-04 7.66e-03 0.21600 3.72e-02 0.212000 5.77e-01 1.48e-03
REDUCTION OF CYTOSOLIC CA LEVELS 12 9.64e-02 2.21e-01 0.21500 -1.77e-01 0.123000 2.88e-01 4.62e-01
G ALPHA I SIGNALLING EVENTS 204 2.13e-04 2.63e-03 0.21500 1.54e-01 0.149000 1.47e-04 2.38e-04
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 6.29e-01 7.52e-01 0.21400 1.60e-01 0.143000 3.59e-01 4.11e-01
RND1 GTPASE CYCLE 38 3.44e-02 1.09e-01 0.21400 4.36e-02 0.210000 6.42e-01 2.51e-02
FGFR2 MUTANT RECEPTOR ACTIVATION 27 2.91e-01 4.63e-01 0.21400 -1.25e-01 -0.174000 2.62e-01 1.17e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 1.35e-03 1.11e-02 0.21400 1.88e-01 0.103000 3.18e-04 4.93e-02
LATE ENDOSOMAL MICROAUTOPHAGY 31 1.65e-01 3.19e-01 0.21400 1.92e-01 0.094000 6.37e-02 3.65e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 6.50e-02 1.66e-01 0.21400 -1.41e-01 -0.161000 4.97e-02 2.49e-02
MEIOTIC RECOMBINATION 41 9.87e-02 2.24e-01 0.21300 -9.55e-02 -0.191000 2.90e-01 3.48e-02
NEUROTRANSMITTER RELEASE CYCLE 48 5.68e-02 1.50e-01 0.21300 8.87e-02 0.194000 2.88e-01 2.03e-02
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 7.36e-03 3.39e-02 0.21200 -1.75e-01 0.120000 1.22e-01 2.91e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 1.47e-01 2.96e-01 0.21200 1.97e-01 0.080200 6.24e-02 4.47e-01
SHC1 EVENTS IN EGFR SIGNALING 11 1.20e-01 2.59e-01 0.21200 1.55e-01 -0.145000 3.75e-01 4.06e-01
FCERI MEDIATED NF KB ACTIVATION 76 1.74e-03 1.26e-02 0.21100 2.06e-01 0.046400 1.89e-03 4.84e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.16e-01 6.72e-01 0.21100 1.37e-01 0.160000 3.41e-01 2.67e-01
KINESINS 47 3.58e-02 1.12e-01 0.21100 2.00e-01 0.065900 1.76e-02 4.35e-01
SIGNALING BY EGFR 47 1.40e-01 2.87e-01 0.21100 1.32e-01 0.164000 1.16e-01 5.19e-02
RAC3 GTPASE CYCLE 90 2.83e-03 1.75e-02 0.21100 7.50e-02 0.197000 2.19e-01 1.25e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.79e-04 2.29e-03 0.21000 -4.82e-02 -0.205000 3.91e-01 2.72e-04
DOWNSTREAM SIGNAL TRANSDUCTION 29 1.67e-01 3.19e-01 0.20900 7.99e-02 0.194000 4.57e-01 7.12e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 1.25e-01 2.68e-01 0.20900 -2.06e-01 0.034700 1.66e-01 8.16e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 33 1.02e-01 2.29e-01 0.20900 6.56e-02 0.198000 5.14e-01 4.90e-02
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 35 1.04e-01 2.33e-01 0.20800 -7.26e-02 -0.195000 4.57e-01 4.59e-02
NEURONAL SYSTEM 370 5.27e-07 1.88e-05 0.20800 1.37e-01 0.156000 6.01e-06 2.58e-07
MITOTIC G1 PHASE AND G1 S TRANSITION 142 2.03e-03 1.41e-02 0.20700 1.71e-01 0.117000 4.34e-04 1.64e-02
TRIGLYCERIDE METABOLISM 24 3.46e-01 5.14e-01 0.20700 1.16e-01 0.172000 3.26e-01 1.46e-01
EPH EPHRIN SIGNALING 92 2.61e-02 8.78e-02 0.20700 1.58e-01 0.133000 8.88e-03 2.70e-02
G BETA GAMMA SIGNALLING THROUGH CDC42 19 1.39e-01 2.86e-01 0.20700 2.06e-01 0.010300 1.20e-01 9.38e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 5.86e-01 7.22e-01 0.20600 -1.64e-01 -0.125000 3.06e-01 4.37e-01
SIGNALING BY SCF KIT 41 1.62e-01 3.14e-01 0.20600 1.12e-01 0.172000 2.13e-01 5.63e-02
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 6.32e-01 7.54e-01 0.20500 1.44e-01 0.146000 3.86e-01 3.82e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 4.76e-01 6.35e-01 0.20500 1.33e-01 0.156000 3.17e-01 2.38e-01
RND3 GTPASE CYCLE 38 9.86e-02 2.24e-01 0.20500 7.45e-02 0.191000 4.27e-01 4.18e-02
REGULATION OF TNFR1 SIGNALING 34 2.60e-01 4.32e-01 0.20400 1.26e-01 0.160000 2.03e-01 1.06e-01
INTERLEUKIN 37 SIGNALING 18 3.10e-01 4.82e-01 0.20400 6.58e-02 0.193000 6.29e-01 1.57e-01
METABOLISM OF PORPHYRINS 19 2.84e-01 4.57e-01 0.20400 6.36e-02 0.194000 6.31e-01 1.44e-01
REGULATION OF RAS BY GAPS 66 1.57e-02 5.96e-02 0.20300 1.91e-01 0.068900 7.17e-03 3.33e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 1.17e-02 4.80e-02 0.20300 1.39e-01 0.148000 8.99e-03 5.20e-03
PINK1 PRKN MEDIATED MITOPHAGY 22 2.50e-01 4.22e-01 0.20300 1.91e-01 0.067900 1.21e-01 5.82e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 2.01e-01 3.63e-01 0.20300 1.80e-01 0.092600 7.79e-02 3.65e-01
SHC MEDIATED CASCADE FGFR4 13 1.07e-01 2.38e-01 0.20200 1.15e-01 -0.167000 4.74e-01 2.98e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 1.40e-01 2.88e-01 0.20200 1.57e-01 0.126000 5.19e-02 1.19e-01
RORA ACTIVATES GENE EXPRESSION 18 5.55e-02 1.50e-01 0.20100 -1.80e-01 0.089400 1.85e-01 5.11e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 6.64e-02 1.69e-01 0.20100 1.79e-01 -0.089600 2.00e-01 5.23e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 3.87e-01 5.49e-01 0.20100 1.41e-01 0.143000 2.14e-01 2.08e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 5.97e-02 1.56e-01 0.20000 -1.96e-01 -0.042700 3.93e-02 6.53e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 49 2.30e-02 7.98e-02 0.20000 -4.13e-02 -0.196000 6.17e-01 1.76e-02
TRNA PROCESSING IN THE NUCLEUS 56 4.88e-02 1.36e-01 0.20000 8.07e-02 0.183000 2.96e-01 1.79e-02
CD209 DC SIGN SIGNALING 18 5.16e-01 6.72e-01 0.20000 1.31e-01 0.150000 3.35e-01 2.69e-01
GPCR LIGAND BINDING 268 3.25e-06 9.11e-05 0.20000 1.76e-01 0.093400 6.93e-07 8.57e-03
ABC FAMILY PROTEINS MEDIATED TRANSPORT 94 1.72e-02 6.41e-02 0.19900 1.70e-01 0.104000 4.42e-03 8.08e-02
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 144 5.31e-03 2.67e-02 0.19900 1.30e-01 0.151000 7.07e-03 1.82e-03
MISMATCH REPAIR 15 2.07e-01 3.70e-01 0.19900 -2.65e-03 0.199000 9.86e-01 1.82e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 2.90e-01 4.63e-01 0.19900 2.18e-02 0.198000 8.88e-01 2.01e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 8.75e-03 3.87e-02 0.19900 1.96e-01 0.029100 1.03e-02 7.04e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 191 7.26e-05 1.12e-03 0.19900 8.61e-02 0.179000 4.04e-02 2.05e-05
LGI ADAM INTERACTIONS 14 1.67e-01 3.19e-01 0.19800 3.85e-02 -0.195000 8.03e-01 2.07e-01
DSCAM INTERACTIONS 11 2.06e-01 3.68e-01 0.19800 -1.87e-01 0.065200 2.83e-01 7.08e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 97 3.82e-03 2.16e-02 0.19800 7.02e-02 0.185000 2.32e-01 1.68e-03
HDR THROUGH MMEJ ALT NHEJ 10 2.22e-01 3.88e-01 0.19700 -8.04e-02 0.180000 6.60e-01 3.24e-01
NETRIN 1 SIGNALING 50 1.24e-02 5.03e-02 0.19600 1.91e-02 0.196000 8.15e-01 1.68e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 9.33e-02 2.17e-01 0.19600 1.96e-01 -0.004650 1.04e-01 9.69e-01
METAL ION SLC TRANSPORTERS 25 2.53e-01 4.27e-01 0.19600 1.82e-01 0.072600 1.16e-01 5.30e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 4.06e-03 2.21e-02 0.19500 1.95e-01 -0.004120 1.31e-02 9.58e-01
STRIATED MUSCLE CONTRACTION 26 1.97e-01 3.60e-01 0.19500 -1.86e-01 -0.058000 1.00e-01 6.08e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 3.39e-01 5.11e-01 0.19500 1.16e-01 0.157000 2.79e-01 1.44e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 3.07e-03 1.85e-02 0.19500 1.90e-01 0.042000 3.11e-03 5.14e-01
REGULATION OF BACH1 ACTIVITY 11 6.79e-01 7.88e-01 0.19500 1.26e-01 0.148000 4.69e-01 3.95e-01
STABILIZATION OF P53 54 3.92e-03 2.16e-02 0.19400 1.94e-01 -0.006640 1.36e-02 9.33e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 3.72e-01 5.36e-01 0.19400 1.30e-02 0.194000 9.41e-01 2.66e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 67 7.60e-02 1.89e-01 0.19400 1.60e-01 0.109000 2.33e-02 1.22e-01
CILIUM ASSEMBLY 192 4.38e-05 7.58e-04 0.19400 1.79e-01 0.074300 1.91e-05 7.62e-02
EUKARYOTIC TRANSLATION INITIATION 114 6.25e-04 6.08e-03 0.19400 -5.18e-02 -0.187000 3.40e-01 5.74e-04
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 1.29e-01 2.73e-01 0.19400 -1.06e-01 -0.162000 1.86e-01 4.32e-02
METHYLATION 11 4.49e-01 6.14e-01 0.19300 1.90e-01 0.038200 2.76e-01 8.26e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 68 1.01e-01 2.27e-01 0.19300 -1.35e-01 -0.138000 5.37e-02 4.93e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 30 3.03e-01 4.75e-01 0.19300 1.03e-01 0.163000 3.31e-01 1.22e-01
INTERFERON SIGNALING 161 3.30e-09 2.43e-07 0.19200 -1.88e-01 0.040300 3.87e-05 3.78e-01
EFFECTS OF PIP2 HYDROLYSIS 27 3.21e-02 1.03e-01 0.19200 -4.90e-02 0.186000 6.59e-01 9.45e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 1.59e-01 3.09e-01 0.19100 1.79e-01 0.067800 7.10e-02 4.94e-01
SENSORY PERCEPTION 158 2.85e-03 1.76e-02 0.19100 -1.08e-01 -0.158000 1.90e-02 6.27e-04
SIGNALING BY FLT3 FUSION PROTEINS 19 4.58e-01 6.20e-01 0.19100 -1.65e-01 -0.096900 2.13e-01 4.65e-01
RHOBTB GTPASE CYCLE 35 3.09e-01 4.81e-01 0.19000 1.24e-01 0.145000 2.04e-01 1.39e-01
ANCHORING FIBRIL FORMATION 14 5.54e-01 7.02e-01 0.19000 -1.66e-01 -0.091500 2.81e-01 5.53e-01
RNA POLYMERASE I PROMOTER ESCAPE 50 1.13e-01 2.47e-01 0.19000 -8.74e-02 -0.168000 2.85e-01 3.97e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 4.89e-01 6.49e-01 0.18900 1.59e-01 0.104000 2.32e-01 4.33e-01
HEME SIGNALING 46 1.81e-02 6.64e-02 0.18900 -1.89e-01 -0.009460 2.65e-02 9.12e-01
SIGNALING BY GPCR 483 1.81e-07 7.88e-06 0.18900 1.25e-01 0.142000 2.72e-06 9.36e-08
RHO GTPASES ACTIVATE KTN1 11 5.23e-01 6.77e-01 0.18900 5.61e-02 0.181000 7.47e-01 2.99e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 3.42e-03 1.98e-02 0.18900 4.94e-02 0.183000 4.16e-01 2.61e-03
SIGNALING BY FGFR4 34 2.47e-01 4.19e-01 0.18900 1.65e-01 0.092900 9.67e-02 3.49e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 2.48e-01 4.19e-01 0.18900 -1.68e-01 -0.086600 1.00e-01 3.97e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 1.50e-01 2.99e-01 0.18800 1.32e-01 0.135000 8.05e-02 7.35e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 4.97e-01 6.56e-01 0.18800 -5.60e-02 -0.180000 7.37e-01 2.81e-01
PYRIMIDINE SALVAGE 10 7.18e-01 8.14e-01 0.18800 1.21e-01 0.144000 5.09e-01 4.29e-01
CRMPS IN SEMA3A SIGNALING 16 3.97e-01 5.60e-01 0.18800 -1.79e-01 -0.056300 2.14e-01 6.97e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 1.20e-02 4.87e-02 0.18800 -4.50e-02 0.182000 6.36e-01 5.51e-02
CYCLIN D ASSOCIATED EVENTS IN G1 45 2.14e-01 3.77e-01 0.18700 1.11e-01 0.150000 1.96e-01 8.10e-02
PHASE II CONJUGATION OF COMPOUNDS 64 1.30e-01 2.73e-01 0.18700 1.38e-01 0.126000 5.62e-02 8.10e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 5.59e-01 7.04e-01 0.18700 1.50e-01 0.111000 2.84e-01 4.28e-01
BIOLOGICAL OXIDATIONS 126 1.91e-02 6.89e-02 0.18600 1.35e-01 0.129000 9.00e-03 1.26e-02
CIRCADIAN CLOCK 68 7.75e-04 7.09e-03 0.18600 -2.42e-02 0.185000 7.30e-01 8.48e-03
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.57e-01 7.03e-01 0.18600 5.20e-02 0.178000 7.76e-01 3.29e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 2.90e-03 1.76e-02 0.18600 1.85e-01 -0.014700 1.39e-02 8.45e-01
RAC1 GTPASE CYCLE 177 4.41e-07 1.62e-05 0.18600 1.02e-02 0.185000 8.15e-01 2.13e-05
BASIGIN INTERACTIONS 22 2.60e-01 4.32e-01 0.18500 4.56e-02 0.179000 7.11e-01 1.46e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 4.34e-01 5.97e-01 0.18400 1.26e-01 0.134000 2.56e-01 2.27e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 1.17e-01 2.55e-01 0.18400 -1.50e-01 0.107000 3.14e-01 4.75e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.73e-03 2.81e-02 0.18400 1.83e-01 -0.014900 2.09e-02 8.51e-01
METABOLISM OF VITAMINS AND COFACTORS 151 9.38e-03 4.09e-02 0.18400 1.20e-01 0.139000 1.08e-02 3.28e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 4.62e-03 2.43e-02 0.18300 1.83e-01 0.017000 8.30e-03 8.06e-01
PEXOPHAGY 11 7.16e-01 8.12e-01 0.18300 1.26e-01 0.133000 4.71e-01 4.46e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 3.37e-01 5.10e-01 0.18300 -3.56e-02 0.179000 8.46e-01 3.27e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 4.16e-01 5.78e-01 0.18300 1.10e-01 0.146000 3.25e-01 1.89e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 2.34e-01 4.03e-01 0.18200 -4.17e-02 0.178000 7.95e-01 2.68e-01
ESTROGEN DEPENDENT GENE EXPRESSION 107 4.02e-02 1.22e-01 0.18200 -1.27e-01 -0.131000 2.38e-02 1.91e-02
G ALPHA 12 13 SIGNALLING EVENTS 75 5.60e-03 2.78e-02 0.18200 2.80e-02 0.180000 6.75e-01 7.06e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 5.91e-01 7.26e-01 0.18200 1.39e-01 0.117000 3.20e-01 4.03e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 1.36e-01 2.82e-01 0.18200 3.23e-02 0.179000 7.60e-01 8.97e-02
TRANSPORT OF SMALL MOLECULES 582 1.09e-08 6.78e-07 0.18100 1.07e-01 0.147000 1.08e-05 1.72e-09
RHO GTPASE CYCLE 422 1.04e-11 1.75e-09 0.18100 4.06e-02 0.177000 1.54e-01 5.24e-10
ASSEMBLY OF THE HIV VIRION 16 3.70e-01 5.35e-01 0.18100 1.77e-01 0.038700 2.21e-01 7.89e-01
DNA STRAND ELONGATION 32 1.28e-01 2.71e-01 0.18100 3.48e-02 0.178000 7.33e-01 8.22e-02
COLLAGEN DEGRADATION 52 6.97e-02 1.75e-01 0.18000 -5.73e-02 -0.171000 4.75e-01 3.32e-02
GROWTH HORMONE RECEPTOR SIGNALING 20 4.97e-01 6.56e-01 0.18000 1.53e-01 0.095300 2.37e-01 4.61e-01
INNATE IMMUNE SYSTEM 779 2.35e-10 2.76e-08 0.18000 1.35e-01 0.119000 1.76e-10 2.11e-08
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 7.05e-01 8.07e-01 0.17900 1.28e-01 0.125000 4.43e-01 4.52e-01
FRS MEDIATED FGFR3 SIGNALING 15 5.55e-01 7.02e-01 0.17900 1.59e-01 0.081800 2.86e-01 5.84e-01
L1CAM INTERACTIONS 108 2.99e-02 9.70e-02 0.17900 1.47e-01 0.101000 8.13e-03 6.93e-02
CELL CELL COMMUNICATION 106 4.92e-03 2.53e-02 0.17900 5.73e-02 0.169000 3.08e-01 2.59e-03
INFLUENZA INFECTION 145 1.46e-02 5.68e-02 0.17800 -1.17e-01 -0.134000 1.47e-02 5.29e-03
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 2.62e-01 4.33e-01 0.17800 1.69e-01 0.057500 1.30e-01 6.05e-01
GLUTATHIONE CONJUGATION 30 4.07e-01 5.70e-01 0.17800 1.39e-01 0.111000 1.89e-01 2.91e-01
PCP CE PATHWAY 89 6.57e-03 3.10e-02 0.17800 1.72e-01 0.044000 4.97e-03 4.74e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 2.71e-01 4.44e-01 0.17700 1.01e-01 0.146000 2.62e-01 1.06e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 185 3.64e-04 4.08e-03 0.17700 1.63e-01 0.070200 1.34e-04 1.00e-01
SARS COV INFECTIONS 140 1.67e-02 6.25e-02 0.17600 1.37e-01 0.110000 5.01e-03 2.42e-02
SIGNALING BY FGFR2 IN DISEASE 37 3.33e-01 5.05e-01 0.17600 -1.09e-01 -0.139000 2.52e-01 1.44e-01
PI 3K CASCADE FGFR1 16 2.08e-01 3.70e-01 0.17600 -1.74e-01 0.029300 2.29e-01 8.39e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 3.93e-03 2.16e-02 0.17600 1.71e-01 -0.041200 3.12e-02 6.04e-01
SIGNALING BY MET 74 1.26e-02 5.09e-02 0.17600 3.64e-02 0.172000 5.89e-01 1.06e-02
SIGNALING BY THE B CELL RECEPTOR BCR 103 2.15e-02 7.54e-02 0.17600 1.56e-01 0.081100 6.33e-03 1.55e-01
S PHASE 154 1.40e-02 5.55e-02 0.17500 1.27e-01 0.121000 6.65e-03 9.57e-03
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 2.00e-01 3.62e-01 0.17500 -1.61e-02 -0.174000 8.94e-01 1.49e-01
HIV INFECTION 221 2.30e-03 1.51e-02 0.17500 1.28e-01 0.119000 1.06e-03 2.36e-03
SELENOAMINO ACID METABOLISM 108 8.89e-03 3.90e-02 0.17400 -6.42e-02 -0.162000 2.50e-01 3.60e-03
SUMOYLATION OF RNA BINDING PROTEINS 45 2.31e-02 8.01e-02 0.17400 -7.57e-03 0.174000 9.30e-01 4.31e-02
FGFR1 LIGAND BINDING AND ACTIVATION 10 7.31e-01 8.23e-01 0.17400 -1.45e-01 -0.096600 4.29e-01 5.97e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 2.92e-01 4.65e-01 0.17400 1.67e-01 0.048200 1.57e-01 6.83e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 2.03e-11 2.99e-09 0.17400 7.06e-02 0.159000 2.62e-03 1.30e-11
DNA REPLICATION PRE INITIATION 80 5.11e-02 1.41e-01 0.17400 1.55e-01 0.078300 1.66e-02 2.26e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.62e-01 4.33e-01 0.17400 -5.48e-02 -0.165000 6.15e-01 1.32e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 47 4.87e-02 1.36e-01 0.17300 -2.41e-02 -0.172000 7.75e-01 4.16e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 6.51e-01 7.68e-01 0.17300 1.36e-01 0.108000 3.63e-01 4.70e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 2.24e-01 3.91e-01 0.17300 -1.56e-01 -0.075000 9.18e-02 4.18e-01
G1 S DNA DAMAGE CHECKPOINTS 65 1.94e-03 1.36e-02 0.17300 1.70e-01 -0.031600 1.77e-02 6.60e-01
GLYCOLYSIS 67 1.65e-01 3.19e-01 0.17200 1.21e-01 0.123000 8.75e-02 8.14e-02
ADAPTIVE IMMUNE SYSTEM 608 9.45e-08 4.63e-06 0.17200 1.31e-01 0.112000 3.82e-08 2.79e-06
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 4.70e-01 6.31e-01 0.17100 1.65e-01 0.046400 2.69e-01 7.56e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 6.09e-01 7.40e-01 0.17100 1.61e-01 0.056600 3.55e-01 7.45e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 2.21e-01 3.87e-01 0.17000 1.49e-01 0.082700 8.47e-02 3.37e-01
ONCOGENIC MAPK SIGNALING 77 9.91e-02 2.24e-01 0.17000 9.39e-02 0.142000 1.55e-01 3.16e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.66e-01 3.19e-01 0.17000 -1.70e-01 0.004710 1.58e-01 9.69e-01
TIE2 SIGNALING 17 6.39e-01 7.58e-01 0.17000 1.25e-01 0.115000 3.73e-01 4.10e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 4.62e-02 1.33e-01 0.17000 1.64e-01 -0.043100 1.13e-01 6.78e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 106 5.00e-02 1.39e-01 0.17000 -1.37e-01 -0.100000 1.50e-02 7.44e-02
FGFR1 MUTANT RECEPTOR ACTIVATION 26 1.71e-01 3.24e-01 0.16900 1.16e-02 0.169000 9.18e-01 1.36e-01
REGULATION OF FZD BY UBIQUITINATION 19 6.10e-01 7.40e-01 0.16900 1.23e-01 0.116000 3.55e-01 3.80e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 3.42e-01 5.12e-01 0.16900 -9.59e-02 -0.139000 3.13e-01 1.44e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 2.08e-01 3.70e-01 0.16900 1.34e-01 -0.102000 4.01e-01 5.25e-01
DEATH RECEPTOR SIGNALLING 132 2.90e-03 1.76e-02 0.16900 5.44e-02 0.160000 2.81e-01 1.56e-03
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.60e-02 6.05e-02 0.16900 -1.80e-02 -0.168000 8.02e-01 1.95e-02
MITOCHONDRIAL TRANSLATION 93 7.25e-05 1.12e-03 0.16900 5.32e-02 -0.160000 3.76e-01 7.72e-03
TRANSCRIPTIONAL REGULATION BY MECP2 59 2.49e-02 8.46e-02 0.16800 -1.67e-01 -0.019300 2.65e-02 7.98e-01
AQUAPORIN MEDIATED TRANSPORT 41 2.59e-01 4.32e-01 0.16800 1.47e-01 0.080600 1.03e-01 3.72e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 6.23e-02 1.61e-01 0.16700 -5.33e-02 -0.159000 4.65e-01 2.96e-02
HEMOSTASIS 478 5.69e-06 1.46e-04 0.16700 1.09e-01 0.127000 4.99e-05 2.05e-06
SYNAPTIC ADHESION LIKE MOLECULES 21 4.73e-01 6.32e-01 0.16700 1.50e-01 0.071900 2.33e-01 5.69e-01
LONG TERM POTENTIATION 23 4.07e-01 5.70e-01 0.16700 6.34e-02 0.154000 5.99e-01 2.01e-01
PI 3K CASCADE FGFR3 13 2.54e-01 4.27e-01 0.16600 -6.38e-02 0.154000 6.90e-01 3.37e-01
MYOGENESIS 25 6.35e-02 1.64e-01 0.16600 -7.58e-02 0.148000 5.12e-01 2.00e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 3.39e-01 5.11e-01 0.16600 4.82e-02 -0.159000 7.82e-01 3.60e-01
TRANSLESION SYNTHESIS BY POLK 17 6.50e-01 7.67e-01 0.16600 -1.24e-01 -0.110000 3.75e-01 4.31e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 1.74e-01 3.27e-01 0.16600 8.94e-02 0.140000 2.31e-01 6.13e-02
TRANSCRIPTIONAL REGULATION BY RUNX1 182 2.35e-03 1.52e-02 0.16600 -7.57e-02 -0.147000 7.83e-02 6.18e-04
NUCLEAR SIGNALING BY ERBB4 31 4.53e-01 6.20e-01 0.16600 1.27e-01 0.107000 2.22e-01 3.04e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 162 2.46e-05 4.74e-04 0.16600 -9.54e-03 -0.165000 8.34e-01 2.88e-04
INTERLEUKIN 12 FAMILY SIGNALING 43 7.91e-02 1.92e-01 0.16500 1.64e-01 0.022000 6.28e-02 8.03e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 2.76e-01 4.49e-01 0.16500 1.18e-01 -0.116000 4.99e-01 5.07e-01
INTERLEUKIN 12 SIGNALING 37 1.12e-01 2.45e-01 0.16400 1.63e-01 0.020200 8.58e-02 8.32e-01
DISEASES OF GLYCOSYLATION 123 2.97e-02 9.68e-02 0.16400 1.39e-01 0.088100 8.01e-03 9.16e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 1.61e-02 6.07e-02 0.16400 1.60e-01 0.036200 1.23e-02 5.71e-01
TOLL LIKE RECEPTOR CASCADES 138 1.48e-02 5.72e-02 0.16400 8.08e-02 0.142000 1.01e-01 3.90e-03
RHO GTPASE EFFECTORS 251 2.46e-03 1.56e-02 0.16300 1.20e-01 0.110000 1.07e-03 2.67e-03
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 7.54e-01 8.38e-01 0.16300 9.85e-02 0.130000 5.72e-01 4.56e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 5.59e-01 7.04e-01 0.16300 1.42e-01 0.079700 2.84e-01 5.48e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 5.15e-01 6.72e-01 0.16300 1.58e-01 0.040400 3.07e-01 7.93e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 3.45e-01 5.14e-01 0.16200 -1.03e-01 -0.125000 2.41e-01 1.55e-01
TCR SIGNALING 101 1.49e-02 5.74e-02 0.16200 1.54e-01 0.050700 7.59e-03 3.78e-01
C TYPE LECTIN RECEPTORS CLRS 112 1.38e-02 5.49e-02 0.16200 1.51e-01 0.058000 5.77e-03 2.89e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 93 5.06e-03 2.58e-02 0.16200 2.03e-02 0.160000 7.35e-01 7.52e-03
ORC1 REMOVAL FROM CHROMATIN 67 2.37e-02 8.15e-02 0.16200 1.60e-01 0.022100 2.35e-02 7.55e-01
MITOCHONDRIAL PROTEIN IMPORT 63 3.72e-02 1.15e-01 0.16100 1.59e-01 0.028700 2.93e-02 6.93e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 5.01e-01 6.58e-01 0.16100 1.61e-01 -0.002690 3.78e-01 9.88e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 6.27e-01 7.52e-01 0.16000 -1.39e-01 -0.080400 3.36e-01 5.78e-01
MITOTIC PROMETAPHASE 177 7.78e-03 3.51e-02 0.16000 8.48e-02 0.136000 5.18e-02 1.84e-03
ENOS ACTIVATION 11 5.77e-01 7.19e-01 0.16000 1.57e-01 0.031100 3.68e-01 8.58e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 1.31e-02 5.27e-02 0.16000 1.57e-01 0.029700 1.20e-02 6.34e-01
CDC42 GTPASE CYCLE 153 8.81e-06 2.16e-04 0.15900 -2.03e-02 0.158000 6.65e-01 7.77e-04
MET PROMOTES CELL MOTILITY 39 2.84e-02 9.38e-02 0.15900 -5.01e-02 0.151000 5.88e-01 1.04e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.36e-03 1.52e-02 0.15900 -3.35e-02 0.155000 6.21e-01 2.21e-02
INTERLEUKIN 2 FAMILY SIGNALING 32 3.56e-02 1.12e-01 0.15900 -8.56e-02 0.133000 4.02e-01 1.92e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 5.83e-01 7.21e-01 0.15800 8.39e-02 0.134000 5.16e-01 2.99e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 3.40e-01 5.11e-01 0.15800 9.03e-02 0.129000 3.06e-01 1.42e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 1.60e-03 1.23e-02 0.15700 1.18e-01 0.104000 5.89e-04 2.52e-03
SIGNALING BY PTK6 50 3.21e-01 4.93e-01 0.15700 1.04e-01 0.118000 2.02e-01 1.50e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 2.85e-01 4.58e-01 0.15700 1.42e-01 -0.066400 3.74e-01 6.79e-01
DEGRADATION OF AXIN 53 6.71e-02 1.70e-01 0.15700 1.55e-01 0.024800 5.12e-02 7.55e-01
NICOTINAMIDE SALVAGING 14 2.35e-01 4.05e-01 0.15700 -9.04e-02 0.128000 5.58e-01 4.07e-01
DISEASES OF METABOLISM 197 1.23e-02 4.97e-02 0.15600 1.19e-01 0.101000 4.16e-03 1.43e-02
PHASE 2 PLATEAU PHASE 10 6.10e-01 7.40e-01 0.15600 -1.54e-01 -0.026700 4.00e-01 8.84e-01
INTERLEUKIN 1 SIGNALING 96 7.84e-02 1.92e-01 0.15600 1.33e-01 0.081200 2.43e-02 1.69e-01
DEGRADATION OF DVL 55 1.96e-02 6.98e-02 0.15500 1.54e-01 -0.017100 4.81e-02 8.26e-01
CELL CELL JUNCTION ORGANIZATION 48 3.25e-01 4.97e-01 0.15500 9.28e-02 0.124000 2.66e-01 1.37e-01
SIGNALING BY KIT IN DISEASE 20 3.84e-01 5.46e-01 0.15500 2.83e-02 0.152000 8.27e-01 2.38e-01
REGULATION OF IFNA SIGNALING 12 2.93e-01 4.65e-01 0.15500 -1.21e-01 0.096600 4.68e-01 5.63e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 4.69e-01 6.30e-01 0.15500 1.18e-01 0.100000 2.34e-01 3.11e-01
RNA POLYMERASE III TRANSCRIPTION 41 2.76e-01 4.49e-01 0.15500 -6.50e-02 -0.141000 4.71e-01 1.20e-01
INITIAL TRIGGERING OF COMPLEMENT 12 7.68e-01 8.47e-01 0.15500 1.03e-01 0.116000 5.38e-01 4.88e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 6.67e-04 6.39e-03 0.15400 -8.93e-02 0.126000 1.87e-01 6.26e-02
M PHASE 343 6.24e-04 6.08e-03 0.15400 1.16e-01 0.102000 2.30e-04 1.24e-03
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 7.06e-01 8.07e-01 0.15400 -7.66e-02 -0.133000 6.33e-01 4.06e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 7.69e-01 8.47e-01 0.15300 8.75e-02 0.126000 6.15e-01 4.69e-01
CLEC7A DECTIN 1 SIGNALING 94 2.15e-02 7.54e-02 0.15300 1.48e-01 0.040200 1.32e-02 5.00e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 68 2.01e-01 3.63e-01 0.15300 -8.81e-02 -0.125000 2.09e-01 7.39e-02
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 5.75e-01 7.18e-01 0.15300 9.68e-02 0.119000 4.02e-01 3.04e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 7.25e-01 8.20e-01 0.15300 6.05e-02 0.141000 7.40e-01 4.41e-01
RRNA PROCESSING 194 1.71e-03 1.25e-02 0.15300 -5.77e-02 -0.142000 1.66e-01 6.81e-04
THE NLRP3 INFLAMMASOME 15 3.47e-01 5.14e-01 0.15300 -1.52e-01 0.018700 3.09e-01 9.00e-01
ECM PROTEOGLYCANS 68 2.32e-01 4.02e-01 0.15300 -1.01e-01 -0.115000 1.52e-01 1.01e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 1.63e-01 3.16e-01 0.15300 1.43e-01 0.053000 7.41e-02 5.08e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 5.69e-01 7.13e-01 0.15200 9.81e-02 0.117000 3.87e-01 3.03e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 62 2.41e-01 4.11e-01 0.15200 1.23e-01 0.089600 9.30e-02 2.23e-01
RHO GTPASES ACTIVATE PKNS 50 3.84e-02 1.17e-01 0.15200 1.01e-02 -0.152000 9.02e-01 6.38e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.43e-01 5.13e-01 0.15200 1.03e-01 0.111000 2.02e-01 1.69e-01
MET ACTIVATES PTK2 SIGNALING 29 1.21e-01 2.61e-01 0.15200 -1.50e-01 0.025000 1.63e-01 8.16e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 44 3.20e-01 4.92e-01 0.15200 7.65e-02 0.131000 3.80e-01 1.33e-01
DNA REPLICATION 122 3.67e-02 1.14e-01 0.15100 1.33e-01 0.071800 1.10e-02 1.71e-01
PURINE CATABOLISM 16 6.12e-01 7.40e-01 0.15100 1.38e-01 0.061800 3.39e-01 6.68e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 3.16e-01 4.87e-01 0.15100 3.67e-03 0.151000 9.77e-01 2.42e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 72 7.46e-03 3.42e-02 0.15100 -1.74e-02 0.150000 7.99e-01 2.79e-02
REPRODUCTION 80 1.72e-01 3.25e-01 0.15100 -9.05e-02 -0.120000 1.62e-01 6.28e-02
TRANSCRIPTIONAL REGULATION BY E2F6 34 4.56e-01 6.20e-01 0.15100 8.53e-02 0.124000 3.90e-01 2.11e-01
INTERLEUKIN 15 SIGNALING 12 5.79e-01 7.21e-01 0.15000 -1.48e-01 -0.026800 3.74e-01 8.72e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 1.57e-01 3.08e-01 0.15000 1.45e-01 -0.037800 2.19e-01 7.49e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 7.07e-01 8.07e-01 0.15000 7.70e-02 0.128000 6.18e-01 4.06e-01
ADHERENS JUNCTIONS INTERACTIONS 30 5.01e-01 6.58e-01 0.14900 8.30e-02 0.124000 4.32e-01 2.40e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 314 7.62e-05 1.15e-03 0.14800 1.37e-01 0.056600 3.24e-05 8.49e-02
FRS MEDIATED FGFR4 SIGNALING 15 3.16e-01 4.87e-01 0.14800 1.42e-01 -0.040900 3.41e-01 7.84e-01
CELL JUNCTION ORGANIZATION 73 1.25e-01 2.67e-01 0.14700 6.16e-02 0.134000 3.63e-01 4.79e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 3.61e-01 5.27e-01 0.14700 -9.36e-02 0.113000 5.91e-01 5.15e-01
CELLULAR RESPONSE TO HYPOXIA 72 1.57e-02 5.96e-02 0.14700 1.47e-01 -0.003810 3.17e-02 9.55e-01
CELL CYCLE MITOTIC 478 1.10e-04 1.56e-03 0.14600 1.08e-01 0.098700 5.43e-05 2.26e-04
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 3.67e-01 5.33e-01 0.14600 -1.39e-01 0.045800 3.87e-01 7.75e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 4.60e-01 6.20e-01 0.14600 1.33e-01 0.058300 2.30e-01 6.00e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.05e-01 8.72e-01 0.14600 8.22e-02 0.120000 6.53e-01 5.11e-01
LAGGING STRAND SYNTHESIS 20 2.55e-01 4.29e-01 0.14500 -2.70e-02 0.143000 8.35e-01 2.68e-01
SIGNALING BY ACTIVIN 11 6.80e-01 7.88e-01 0.14500 4.22e-02 0.139000 8.09e-01 4.25e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 7.55e-01 8.40e-01 0.14500 1.29e-01 0.067300 4.60e-01 6.99e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 5.23e-01 6.77e-01 0.14500 1.15e-01 0.087300 2.59e-01 3.93e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 346 1.60e-03 1.23e-02 0.14400 1.04e-01 0.100000 8.79e-04 1.42e-03
SIGNALING BY ERBB4 57 2.67e-01 4.39e-01 0.14400 1.24e-01 0.073600 1.05e-01 3.37e-01
PHASE 0 RAPID DEPOLARISATION 28 5.89e-01 7.24e-01 0.14400 -1.00e-01 -0.104000 3.58e-01 3.42e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 7.93e-02 1.93e-01 0.14400 1.41e-01 0.030300 5.11e-02 6.75e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 3.60e-01 5.27e-01 0.14400 1.25e-01 0.071300 1.56e-01 4.19e-01
INWARDLY RECTIFYING K CHANNELS 32 5.38e-01 6.90e-01 0.14400 1.11e-01 0.091300 2.78e-01 3.71e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 6.75e-01 7.86e-01 0.14300 -1.13e-01 -0.088800 3.83e-01 4.92e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 5.30e-01 6.82e-01 0.14300 -2.07e-02 0.142000 9.10e-01 4.37e-01
BASE EXCISION REPAIR 60 1.90e-01 3.52e-01 0.14300 -5.76e-02 -0.131000 4.40e-01 7.91e-02
SNRNP ASSEMBLY 51 1.03e-01 2.31e-01 0.14300 1.80e-02 0.142000 8.24e-01 7.96e-02
NICOTINATE METABOLISM 23 4.71e-01 6.31e-01 0.14300 4.45e-02 0.136000 7.12e-01 2.59e-01
RAS PROCESSING 24 4.87e-01 6.47e-01 0.14300 1.33e-01 0.051400 2.58e-01 6.63e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 284 4.44e-03 2.38e-02 0.14300 8.96e-02 0.111000 9.49e-03 1.25e-03
ZINC TRANSPORTERS 16 5.90e-01 7.24e-01 0.14300 1.36e-01 0.043800 3.46e-01 7.62e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 462 1.24e-04 1.69e-03 0.14300 8.46e-02 0.115000 1.87e-03 2.50e-05
DNA DAMAGE RECOGNITION IN GG NER 38 4.45e-01 6.09e-01 0.14300 1.19e-01 0.077900 2.03e-01 4.06e-01
SIGNALING BY EGFR IN CANCER 22 2.60e-01 4.32e-01 0.14200 1.74e-02 -0.141000 8.88e-01 2.51e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 6.16e-01 7.42e-01 0.14200 -7.86e-02 -0.119000 5.14e-01 3.25e-01
PEPTIDE LIGAND BINDING RECEPTORS 110 5.43e-03 2.72e-02 0.14200 1.42e-01 0.009980 1.04e-02 8.57e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 3.75e-01 5.39e-01 0.14200 -1.36e-01 0.038200 3.77e-01 8.04e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 5.07e-02 1.41e-01 0.14200 1.42e-01 0.003570 5.98e-02 9.62e-01
NOD1 2 SIGNALING PATHWAY 35 2.14e-01 3.77e-01 0.14100 1.67e-02 0.140000 8.64e-01 1.51e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 7.81e-01 8.55e-01 0.14100 -1.11e-01 -0.086900 4.88e-01 5.88e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 3.13e-01 4.84e-01 0.14100 -1.28e-01 0.059000 3.91e-01 6.92e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 40 3.01e-01 4.73e-01 0.14100 -4.79e-02 -0.132000 6.00e-01 1.48e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 3.31e-01 5.04e-01 0.14000 3.89e-02 0.135000 6.99e-01 1.80e-01
CHAPERONE MEDIATED AUTOPHAGY 20 3.51e-01 5.18e-01 0.14000 1.40e-01 -0.002900 2.79e-01 9.82e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 94 6.17e-02 1.60e-01 0.14000 1.32e-01 0.047600 2.75e-02 4.26e-01
POLO LIKE KINASE MEDIATED EVENTS 14 4.68e-01 6.30e-01 0.14000 1.40e-01 -0.006820 3.65e-01 9.65e-01
CELLULAR RESPONSE TO STARVATION 146 3.59e-03 2.05e-02 0.14000 -2.59e-02 -0.137000 5.90e-01 4.20e-03
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 94 7.72e-02 1.91e-01 0.14000 5.33e-02 0.129000 3.72e-01 3.08e-02
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 5.80e-01 7.21e-01 0.14000 -1.22e-01 -0.067500 3.01e-01 5.67e-01
PLASMA LIPOPROTEIN REMODELING 14 4.92e-01 6.51e-01 0.13900 -8.18e-05 0.139000 1.00e+00 3.67e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 6.00e-01 7.34e-01 0.13900 -1.38e-01 -0.007910 4.27e-01 9.64e-01
SIGNALING BY FGFR1 IN DISEASE 33 2.78e-01 4.50e-01 0.13900 2.42e-02 0.136000 8.10e-01 1.75e-01
O LINKED GLYCOSYLATION 85 1.89e-01 3.52e-01 0.13900 7.80e-02 0.114000 2.14e-01 6.82e-02
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 6.34e-01 7.56e-01 0.13900 1.26e-01 0.057800 3.55e-01 6.71e-01
OTHER SEMAPHORIN INTERACTIONS 19 5.75e-01 7.18e-01 0.13800 -1.30e-01 -0.047000 3.26e-01 7.23e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 6.40e-01 7.59e-01 0.13700 1.33e-01 0.032600 4.05e-01 8.39e-01
MICRORNA MIRNA BIOGENESIS 24 6.13e-01 7.40e-01 0.13700 -7.21e-02 -0.117000 5.41e-01 3.23e-01
SHC MEDIATED CASCADE FGFR3 13 4.56e-01 6.20e-01 0.13700 1.35e-01 -0.025100 4.01e-01 8.75e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 7.07e-01 8.07e-01 0.13700 1.33e-01 0.031200 4.66e-01 8.65e-01
HOMOLOGY DIRECTED REPAIR 111 4.41e-02 1.29e-01 0.13700 -1.28e-01 -0.047000 1.94e-02 3.93e-01
INTERLEUKIN 1 FAMILY SIGNALING 123 1.07e-01 2.38e-01 0.13700 1.10e-01 0.081700 3.58e-02 1.18e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.46e-01 2.95e-01 0.13700 6.29e-02 0.121000 3.16e-01 5.32e-02
GLUCAGON TYPE LIGAND RECEPTORS 26 1.83e-01 3.43e-01 0.13600 3.78e-02 -0.131000 7.38e-01 2.48e-01
RHOH GTPASE CYCLE 37 5.35e-01 6.87e-01 0.13600 1.02e-01 0.090000 2.85e-01 3.44e-01
METABOLISM OF FOLATE AND PTERINES 15 7.38e-01 8.29e-01 0.13500 1.16e-01 0.069500 4.37e-01 6.41e-01
MITOTIC PROPHASE 97 1.99e-01 3.62e-01 0.13500 9.10e-02 0.099900 1.21e-01 8.92e-02
PLASMA LIPOPROTEIN ASSEMBLY 12 7.58e-01 8.41e-01 0.13500 5.90e-02 0.121000 7.23e-01 4.67e-01
CROSSLINKING OF COLLAGEN FIBRILS 15 6.25e-01 7.51e-01 0.13400 -3.58e-02 -0.130000 8.10e-01 3.85e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.81e-01 3.40e-01 0.13400 -1.13e-01 0.071600 3.48e-01 5.52e-01
ION TRANSPORT BY P TYPE ATPASES 50 9.67e-02 2.21e-01 0.13300 -1.12e-03 0.133000 9.89e-01 1.03e-01
CRISTAE FORMATION 31 1.09e-01 2.41e-01 0.13300 6.37e-02 -0.117000 5.39e-01 2.60e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 32 1.60e-01 3.12e-01 0.13300 2.48e-02 -0.131000 8.08e-01 2.00e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 9.09e-02 2.13e-01 0.13200 1.32e-01 0.015600 7.33e-02 8.32e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 77 2.93e-01 4.65e-01 0.13200 8.95e-02 0.097500 1.75e-01 1.39e-01
RUNX3 REGULATES NOTCH SIGNALING 13 3.79e-01 5.42e-01 0.13200 -1.03e-01 0.083200 5.22e-01 6.04e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 3.83e-01 5.45e-01 0.13200 -2.51e-02 -0.130000 8.18e-01 2.36e-01
G PROTEIN ACTIVATION 23 1.80e-01 3.39e-01 0.13200 8.61e-02 -0.099800 4.75e-01 4.07e-01
HCMV INFECTION 106 1.82e-01 3.40e-01 0.13100 8.36e-02 0.101000 1.37e-01 7.20e-02
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 5.29e-01 6.82e-01 0.13100 2.98e-02 0.128000 8.18e-01 3.23e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 3.48e-01 5.15e-01 0.13100 -1.59e-02 -0.130000 8.84e-01 2.34e-01
PI3K AKT SIGNALING IN CANCER 91 1.08e-01 2.40e-01 0.13100 4.88e-02 0.121000 4.22e-01 4.53e-02
PROGRAMMED CELL DEATH 186 6.78e-03 3.16e-02 0.13100 1.24e-01 0.041400 3.57e-03 3.31e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 4.10e-01 5.72e-01 0.13100 1.27e-01 0.032000 2.38e-01 7.65e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.29e-01 7.52e-01 0.13100 1.18e-01 0.055900 3.49e-01 6.58e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 6.50e-01 7.67e-01 0.13000 9.15e-02 0.092800 4.02e-01 3.95e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 5.84e-01 7.21e-01 0.13000 1.20e-01 0.051200 3.20e-01 6.71e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 4.33e-01 5.97e-01 0.13000 6.99e-02 -0.109000 6.75e-01 5.13e-01
GENE SILENCING BY RNA 85 2.02e-01 3.64e-01 0.12900 -1.12e-01 -0.065200 7.50e-02 2.99e-01
DAP12 INTERACTIONS 30 3.46e-01 5.14e-01 0.12900 -1.28e-01 -0.018800 2.25e-01 8.59e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.62e-01 4.33e-01 0.12900 -1.28e-01 -0.018800 1.73e-01 8.41e-01
RNA POLYMERASE I TRANSCRIPTION 70 2.82e-01 4.55e-01 0.12900 -6.76e-02 -0.110000 3.28e-01 1.12e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 5.95e-01 7.28e-01 0.12900 -1.09e-01 -0.068100 3.08e-01 5.26e-01
VIRAL MESSENGER RNA SYNTHESIS 42 5.17e-02 1.42e-01 0.12900 -9.89e-02 0.082100 2.68e-01 3.57e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 5.01e-01 6.58e-01 0.12800 -1.52e-02 -0.128000 9.09e-01 3.36e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.29e-01 7.52e-01 0.12800 1.14e-01 0.058800 3.44e-01 6.25e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 4.00e-01 5.63e-01 0.12800 7.86e-02 0.101000 3.01e-01 1.82e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 4.72e-01 6.32e-01 0.12800 -1.67e-02 0.127000 9.11e-01 3.94e-01
SIGNALING BY INSULIN RECEPTOR 65 3.81e-01 5.43e-01 0.12800 9.14e-02 0.089700 2.03e-01 2.11e-01
RHO GTPASES ACTIVATE CIT 18 7.43e-01 8.33e-01 0.12800 -7.36e-02 -0.105000 5.89e-01 4.42e-01
SODIUM CALCIUM EXCHANGERS 10 5.21e-01 6.76e-01 0.12800 -5.86e-02 0.114000 7.48e-01 5.34e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 2.75e-01 4.49e-01 0.12800 2.58e-02 0.125000 7.75e-01 1.66e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 8.01e-01 8.68e-01 0.12800 -1.10e-01 -0.063800 5.08e-01 7.02e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 6.92e-01 7.97e-01 0.12700 -8.75e-02 -0.092600 4.49e-01 4.23e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 3.67e-03 2.09e-02 0.12700 7.67e-02 0.101000 1.16e-02 9.20e-04
CHROMATIN MODIFYING ENZYMES 222 2.89e-03 1.76e-02 0.12600 -1.21e-01 -0.035900 1.95e-03 3.57e-01
DISEASES OF IMMUNE SYSTEM 25 4.44e-01 6.09e-01 0.12500 -1.24e-01 -0.020100 2.84e-01 8.62e-01
APOPTOSIS 164 1.16e-02 4.80e-02 0.12500 1.21e-01 0.032900 7.58e-03 4.68e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.52e-01 5.19e-01 0.12500 -4.28e-02 0.118000 7.54e-01 3.87e-01
JOSEPHIN DOMAIN DUBS 11 6.76e-01 7.86e-01 0.12500 1.24e-01 0.012300 4.75e-01 9.44e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 5.36e-01 6.88e-01 0.12400 1.18e-01 -0.040800 5.00e-01 8.15e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 6.09e-01 7.40e-01 0.12400 -1.03e-01 -0.068400 3.20e-01 5.10e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 284 3.93e-03 2.16e-02 0.12400 1.12e-01 0.052700 1.20e-03 1.27e-01
UB SPECIFIC PROCESSING PROTEASES 167 9.42e-02 2.19e-01 0.12400 9.49e-02 0.079100 3.45e-02 7.82e-02
P38MAPK EVENTS 13 8.24e-01 8.83e-01 0.12300 7.32e-02 0.099200 6.48e-01 5.36e-01
COLLAGEN FORMATION 79 2.23e-01 3.89e-01 0.12300 -5.44e-02 -0.110000 4.04e-01 8.99e-02
SUMOYLATION OF TRANSCRIPTION FACTORS 18 4.06e-01 5.70e-01 0.12300 2.68e-02 -0.120000 8.44e-01 3.80e-01
HS GAG DEGRADATION 20 4.59e-01 6.20e-01 0.12300 1.23e-01 0.000544 3.43e-01 9.97e-01
TNFR2 NON CANONICAL NF KB PATHWAY 79 1.66e-01 3.19e-01 0.12200 1.15e-01 0.040700 7.75e-02 5.32e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 68 4.66e-02 1.33e-01 0.12200 1.21e-01 -0.016200 8.56e-02 8.17e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 4.56e-01 6.20e-01 0.12100 2.44e-03 0.121000 9.85e-01 3.36e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 7.53e-01 8.38e-01 0.12100 9.18e-02 0.078400 4.67e-01 5.34e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 3.05e-01 4.77e-01 0.12100 8.07e-02 -0.089600 5.43e-01 4.99e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 3.75e-01 5.39e-01 0.12000 9.59e-02 -0.072400 5.07e-01 6.16e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 6.09e-01 7.40e-01 0.12000 5.48e-02 0.107000 6.16e-01 3.27e-01
NEGATIVE REGULATION OF FLT3 14 4.20e-01 5.82e-01 0.12000 -8.84e-02 0.081300 5.67e-01 5.98e-01
SIGNALING BY FGFR1 44 5.60e-01 7.05e-01 0.12000 8.86e-02 0.081100 3.09e-01 3.52e-01
PREGNENOLONE BIOSYNTHESIS 12 7.27e-01 8.21e-01 0.12000 -2.73e-02 -0.117000 8.70e-01 4.84e-01
PLATELET AGGREGATION PLUG FORMATION 32 6.12e-01 7.40e-01 0.12000 6.39e-02 0.101000 5.32e-01 3.22e-01
OTHER INTERLEUKIN SIGNALING 20 4.92e-01 6.51e-01 0.12000 1.19e-01 0.004240 3.55e-01 9.74e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 118 2.03e-01 3.64e-01 0.11900 9.37e-02 0.073900 7.88e-02 1.66e-01
EARLY PHASE OF HIV LIFE CYCLE 13 5.07e-01 6.63e-01 0.11900 4.17e-02 -0.111000 7.95e-01 4.89e-01
INTERLEUKIN 7 SIGNALING 19 7.52e-01 8.38e-01 0.11800 -1.00e-01 -0.063200 4.50e-01 6.33e-01
TRP CHANNELS 20 3.05e-01 4.77e-01 0.11800 -7.21e-02 0.093600 5.77e-01 4.69e-01
MITOTIC G2 G2 M PHASES 184 1.19e-02 4.87e-02 0.11800 1.14e-01 0.031200 7.74e-03 4.66e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 4.32e-01 5.96e-01 0.11800 9.84e-02 0.065000 1.95e-01 3.92e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 5.49e-01 7.01e-01 0.11800 5.12e-02 -0.106000 7.69e-01 5.43e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.53e-01 9.04e-01 0.11700 9.28e-02 0.072000 5.78e-01 6.66e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.98e-01 6.56e-01 0.11700 -6.91e-02 0.094800 6.79e-01 5.70e-01
TRANSLATION 286 8.07e-08 4.50e-06 0.11700 9.25e-02 -0.071300 7.20e-03 3.84e-02
SHC MEDIATED CASCADE FGFR1 16 6.13e-01 7.40e-01 0.11700 -1.24e-02 -0.116000 9.31e-01 4.22e-01
TELOMERE EXTENSION BY TELOMERASE 22 4.36e-01 5.98e-01 0.11600 1.16e-01 -0.006200 3.45e-01 9.60e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 5.81e-01 7.21e-01 0.11600 -2.33e-03 0.116000 9.88e-01 4.36e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 7.01e-01 8.03e-01 0.11600 -3.45e-02 -0.111000 8.11e-01 4.42e-01
SIGNALING BY INTERLEUKINS 349 1.50e-02 5.77e-02 0.11600 8.22e-02 0.082200 8.43e-03 8.49e-03
DNA DOUBLE STRAND BREAK REPAIR 140 2.49e-02 8.46e-02 0.11600 -1.14e-01 -0.022200 2.00e-02 6.51e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 8.63e-01 9.12e-01 0.11600 -5.99e-02 -0.099100 7.43e-01 5.88e-01
ION HOMEOSTASIS 50 1.42e-01 2.91e-01 0.11500 -1.11e-02 0.115000 8.92e-01 1.60e-01
ERBB2 REGULATES CELL MOTILITY 14 7.74e-01 8.51e-01 0.11500 4.49e-02 0.106000 7.71e-01 4.93e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 5.25e-01 6.78e-01 0.11500 8.70e-02 0.074800 2.74e-01 3.46e-01
CELL CYCLE CHECKPOINTS 245 4.97e-02 1.39e-01 0.11500 8.91e-02 0.072100 1.64e-02 5.23e-02
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 5.02e-01 6.58e-01 0.11400 4.28e-02 -0.106000 7.82e-01 4.94e-01
MAPK6 MAPK4 SIGNALING 83 4.49e-02 1.31e-01 0.11300 1.12e-01 -0.011200 7.68e-02 8.60e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 7.99e-01 8.67e-01 0.11300 3.49e-02 0.107000 8.41e-01 5.38e-01
LEISHMANIA INFECTION 198 8.26e-02 1.99e-01 0.11200 6.44e-02 0.092000 1.19e-01 2.58e-02
PTEN REGULATION 133 6.68e-02 1.70e-01 0.11200 1.07e-01 0.033900 3.33e-02 5.00e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 86 1.92e-02 6.89e-02 0.11200 3.74e-02 -0.106000 5.49e-01 9.08e-02
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 92 2.54e-01 4.27e-01 0.11100 5.11e-02 0.098400 3.97e-01 1.03e-01
ONCOGENE INDUCED SENESCENCE 32 6.93e-01 7.97e-01 0.11100 7.09e-02 0.085100 4.87e-01 4.05e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 5.54e-01 7.02e-01 0.11100 -1.10e-01 -0.013400 3.73e-01 9.13e-01
DISEASES OF PROGRAMMED CELL DEATH 57 1.59e-01 3.09e-01 0.11000 1.47e-03 -0.110000 9.85e-01 1.49e-01
TRAFFICKING OF AMPA RECEPTORS 31 6.96e-01 8.00e-01 0.11000 8.71e-02 0.067900 4.01e-01 5.13e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 4.34e-01 5.97e-01 0.11000 -1.07e-01 0.027900 4.09e-01 8.29e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 7.76e-01 8.51e-01 0.11000 8.96e-02 0.063800 4.77e-01 6.13e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.41e-01 6.93e-01 0.11000 6.59e-02 -0.087800 6.92e-01 5.98e-01
CELL CYCLE 596 1.69e-03 1.25e-02 0.11000 8.22e-02 0.072600 6.33e-04 2.54e-03
SIGNALING BY WNT 272 4.35e-03 2.34e-02 0.11000 1.05e-01 0.030900 2.87e-03 3.82e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 2.74e-01 4.48e-01 0.10900 5.38e-02 0.094600 3.62e-01 1.10e-01
HIV TRANSCRIPTION ELONGATION 42 3.46e-01 5.14e-01 0.10900 -1.49e-02 -0.108000 8.68e-01 2.28e-01
MAPK FAMILY SIGNALING CASCADES 290 4.11e-02 1.24e-01 0.10800 6.63e-02 0.085200 5.24e-02 1.27e-02
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 64 1.43e-01 2.92e-01 0.10800 -2.87e-04 0.108000 9.97e-01 1.36e-01
HIV LIFE CYCLE 142 1.91e-01 3.54e-01 0.10800 6.16e-02 0.088300 2.06e-01 6.95e-02
POLYMERASE SWITCHING 14 5.51e-01 7.02e-01 0.10700 -3.61e-02 0.101000 8.15e-01 5.12e-01
SMOOTH MUSCLE CONTRACTION 33 5.68e-01 7.12e-01 0.10700 -3.76e-02 -0.101000 7.09e-01 3.18e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 62 4.16e-01 5.78e-01 0.10700 -4.85e-02 -0.095600 5.09e-01 1.93e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 15 7.45e-01 8.34e-01 0.10700 1.03e-01 0.029200 4.90e-01 8.45e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 33 2.00e-01 3.62e-01 0.10700 7.01e-02 -0.080400 4.86e-01 4.24e-01
FLT3 SIGNALING IN DISEASE 28 3.64e-01 5.31e-01 0.10700 -1.05e-01 0.017800 3.35e-01 8.70e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 6.97e-01 8.00e-01 0.10700 9.70e-02 0.044100 4.11e-01 7.08e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 1.80e-02 6.64e-02 0.10600 1.06e-01 0.001020 3.06e-02 9.83e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 3.46e-01 5.14e-01 0.10500 1.05e-01 0.008610 2.44e-01 9.24e-01
SIGNALING BY LEPTIN 10 6.65e-01 7.79e-01 0.10500 -3.55e-02 0.098900 8.46e-01 5.88e-01
SIGNALING BY NTRK3 TRKC 17 6.97e-01 8.00e-01 0.10500 -2.15e-02 -0.103000 8.78e-01 4.63e-01
RHO GTPASES ACTIVATE ROCKS 19 7.68e-01 8.47e-01 0.10400 -4.50e-02 -0.093900 7.34e-01 4.78e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 7.74e-01 8.51e-01 0.10300 -9.93e-02 -0.028100 5.20e-01 8.56e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 7.95e-01 8.65e-01 0.10300 7.98e-02 0.065100 5.08e-01 5.89e-01
RESOLUTION OF ABASIC SITES AP SITES 38 6.57e-01 7.74e-01 0.10300 -8.59e-02 -0.056400 3.60e-01 5.48e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 2.61e-01 4.32e-01 0.10300 -8.71e-02 0.054200 4.02e-01 6.02e-01
REGULATION OF TP53 ACTIVITY 152 1.37e-01 2.82e-01 0.10200 4.50e-02 0.091800 3.39e-01 5.10e-02
SIGNALING BY NOTCH4 83 1.44e-01 2.92e-01 0.10200 1.01e-01 0.010600 1.10e-01 8.67e-01
INFLAMMASOMES 19 4.93e-01 6.52e-01 0.10200 -9.72e-02 0.030800 4.63e-01 8.16e-01
DEUBIQUITINATION 241 1.06e-01 2.37e-01 0.10200 7.09e-02 0.073100 5.85e-02 5.08e-02
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 3.64e-01 5.31e-01 0.10100 -1.00e-01 -0.013800 2.39e-01 8.71e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 83 3.36e-02 1.08e-01 0.10100 4.89e-02 -0.088000 4.42e-01 1.66e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 1.92e-01 3.54e-01 0.10000 -1.51e-02 0.099000 8.49e-01 2.13e-01
SIGNALING BY ROBO RECEPTORS 207 2.46e-03 1.56e-02 0.10000 9.59e-03 -0.099600 8.12e-01 1.36e-02
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 5.38e-01 6.90e-01 0.10000 -1.97e-02 0.098000 8.82e-01 4.60e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 7.98e-01 8.67e-01 0.09970 -5.27e-02 -0.084700 6.76e-01 5.02e-01
SIGNALING BY CSF3 G CSF 29 5.63e-01 7.06e-01 0.09960 9.80e-02 0.018200 3.61e-01 8.66e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 4.54e-01 6.20e-01 0.09900 -9.16e-02 -0.037500 2.32e-01 6.24e-01
FANCONI ANEMIA PATHWAY 36 3.60e-01 5.27e-01 0.09890 -9.85e-02 0.008760 3.06e-01 9.28e-01
NEUREXINS AND NEUROLIGINS 54 3.98e-01 5.61e-01 0.09890 2.59e-02 0.095500 7.42e-01 2.25e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 7.19e-01 8.14e-01 0.09850 -1.00e-02 -0.098000 9.47e-01 5.11e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 64 4.59e-01 6.20e-01 0.09830 -8.83e-02 -0.043200 2.22e-01 5.50e-01
G PROTEIN BETA GAMMA SIGNALLING 31 5.95e-01 7.28e-01 0.09760 9.43e-02 0.025100 3.63e-01 8.09e-01
NGF STIMULATED TRANSCRIPTION 36 5.52e-01 7.02e-01 0.09750 9.40e-02 0.025900 3.29e-01 7.88e-01
REPRESSION OF WNT TARGET GENES 14 7.11e-01 8.11e-01 0.09730 -9.33e-04 -0.097300 9.95e-01 5.28e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 74 5.02e-01 6.58e-01 0.09610 -7.88e-02 -0.054900 2.41e-01 4.14e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 4.27e-01 5.91e-01 0.09610 8.22e-02 0.049800 1.93e-01 4.30e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 5.73e-01 7.16e-01 0.09580 2.21e-02 0.093200 8.26e-01 3.54e-01
MEIOSIS 67 5.79e-01 7.21e-01 0.09490 -6.79e-02 -0.066200 3.37e-01 3.49e-01
SIGNALLING TO RAS 19 6.57e-01 7.74e-01 0.09490 4.12e-03 0.094800 9.75e-01 4.75e-01
FLT3 SIGNALING 36 2.98e-01 4.70e-01 0.09470 -3.45e-02 0.088100 7.20e-01 3.60e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 8.43e-01 9.00e-01 0.09460 5.88e-02 0.074200 6.49e-01 5.66e-01
DNA DAMAGE BYPASS 47 3.71e-01 5.35e-01 0.09450 -9.43e-02 -0.006700 2.63e-01 9.37e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 8.77e-01 9.18e-01 0.09450 4.32e-02 0.084100 7.95e-01 6.14e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 8.20e-01 8.82e-01 0.09440 -9.30e-02 -0.016600 5.93e-01 9.24e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 1.29e-01 2.73e-01 0.09400 -6.92e-02 0.063600 3.79e-01 4.19e-01
INFECTIOUS DISEASE 736 2.41e-03 1.54e-02 0.09230 7.53e-02 0.053400 5.35e-04 1.41e-02
ION CHANNEL TRANSPORT 143 1.20e-01 2.59e-01 0.09220 2.39e-02 0.089100 6.21e-01 6.62e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 7.28e-01 8.21e-01 0.09210 8.99e-02 0.020400 4.87e-01 8.75e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 60 1.14e-01 2.49e-01 0.09190 -6.97e-02 0.060000 3.51e-01 4.22e-01
TELOMERE MAINTENANCE 81 3.41e-01 5.12e-01 0.09180 -2.92e-02 -0.087100 6.50e-01 1.76e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 5.60e-01 7.04e-01 0.09170 -9.16e-02 -0.003700 4.02e-01 9.73e-01
SIGNALING BY ERBB2 48 6.12e-01 7.40e-01 0.09130 4.16e-02 0.081300 6.18e-01 3.30e-01
SIGNALING BY FGFR4 IN DISEASE 11 7.30e-01 8.23e-01 0.09110 2.33e-02 -0.088100 8.94e-01 6.13e-01
PLATELET HOMEOSTASIS 78 3.02e-01 4.74e-01 0.09090 2.04e-02 0.088600 7.56e-01 1.76e-01
IRAK4 DEFICIENCY TLR2 4 14 8.91e-01 9.30e-01 0.09040 -7.42e-02 -0.051500 6.31e-01 7.39e-01
METABOLISM OF STEROID HORMONES 21 7.99e-01 8.67e-01 0.08980 8.17e-02 0.037200 5.17e-01 7.68e-01
MAP2K AND MAPK ACTIVATION 36 7.18e-01 8.14e-01 0.08960 7.80e-02 0.044200 4.18e-01 6.46e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.91e-01 7.97e-01 0.08890 -8.47e-02 0.027100 5.97e-01 8.66e-01
HCMV LATE EVENTS 68 1.44e-01 2.92e-01 0.08880 -2.80e-02 0.084300 6.90e-01 2.29e-01
VISUAL PHOTOTRANSDUCTION 61 1.48e-01 2.97e-01 0.08840 4.18e-02 -0.077800 5.73e-01 2.93e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 23 7.60e-01 8.42e-01 0.08800 -2.92e-02 -0.083000 8.08e-01 4.91e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.58e-01 8.41e-01 0.08800 -8.63e-02 0.016900 6.20e-01 9.23e-01
TRANSLESION SYNTHESIS BY POLH 19 7.87e-01 8.59e-01 0.08760 -2.62e-02 -0.083600 8.43e-01 5.28e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 5.53e-01 7.02e-01 0.08750 -1.49e-03 0.087500 9.89e-01 4.15e-01
ACYL CHAIN REMODELLING OF PS 14 8.28e-01 8.86e-01 0.08750 2.27e-02 0.084500 8.83e-01 5.84e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.46e-01 2.95e-01 0.08730 6.65e-02 -0.056700 3.77e-01 4.52e-01
IRS MEDIATED SIGNALLING 41 2.90e-01 4.63e-01 0.08670 -7.62e-02 0.041300 3.98e-01 6.48e-01
SIGNALING BY NOTCH3 48 3.92e-01 5.54e-01 0.08660 -2.63e-05 0.086600 1.00e+00 2.99e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 179 4.70e-02 1.34e-01 0.08660 8.63e-02 0.007880 4.68e-02 8.56e-01
MUSCLE CONTRACTION 160 4.49e-02 1.31e-01 0.08630 -8.63e-02 0.000505 5.99e-02 9.91e-01
OXIDATIVE STRESS INDUCED SENESCENCE 81 3.71e-01 5.35e-01 0.08630 -2.53e-02 -0.082500 6.94e-01 2.00e-01
AMYLOID FIBER FORMATION 61 5.17e-01 6.72e-01 0.08620 -3.13e-02 -0.080300 6.73e-01 2.78e-01
SIGNALING BY NOTCH2 33 7.96e-01 8.66e-01 0.08590 6.64e-02 0.054500 5.09e-01 5.88e-01
G ALPHA S SIGNALLING EVENTS 107 4.84e-01 6.44e-01 0.08550 6.56e-02 0.054800 2.42e-01 3.28e-01
PRE NOTCH EXPRESSION AND PROCESSING 67 6.03e-01 7.36e-01 0.08520 -7.11e-02 -0.047000 3.14e-01 5.06e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 5.34e-01 6.87e-01 0.08510 -3.05e-02 -0.079500 6.85e-01 2.91e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 13 6.93e-01 7.97e-01 0.08500 3.59e-02 -0.077100 8.23e-01 6.30e-01
PI 3K CASCADE FGFR4 13 7.51e-01 8.38e-01 0.08450 -8.36e-02 0.012100 6.02e-01 9.40e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 16 6.22e-01 7.48e-01 0.08390 6.83e-02 -0.048900 6.36e-01 7.35e-01
PYROPTOSIS 21 6.10e-01 7.40e-01 0.08370 1.92e-02 -0.081400 8.79e-01 5.18e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 5.55e-01 7.02e-01 0.08320 8.28e-02 -0.008090 4.40e-01 9.40e-01
MEIOTIC SYNAPSIS 43 7.64e-01 8.45e-01 0.08310 -5.84e-02 -0.059000 5.08e-01 5.03e-01
SIGNALING BY NOTCH1 75 5.49e-01 7.01e-01 0.08310 4.03e-02 0.072600 5.46e-01 2.77e-01
G2 M DNA DAMAGE CHECKPOINT 69 6.38e-01 7.58e-01 0.08290 -5.17e-02 -0.064800 4.57e-01 3.52e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 7.92e-01 8.63e-01 0.08290 8.28e-02 0.004490 5.92e-01 9.77e-01
RA BIOSYNTHESIS PATHWAY 13 8.40e-01 8.97e-01 0.08270 -8.12e-02 -0.015900 6.12e-01 9.21e-01
RET SIGNALING 38 7.87e-01 8.59e-01 0.08240 5.36e-02 0.062600 5.68e-01 5.04e-01
GAB1 SIGNALOSOME 14 6.72e-01 7.84e-01 0.08220 -6.75e-02 0.046900 6.62e-01 7.61e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 2.89e-01 4.62e-01 0.08210 -6.10e-02 0.054900 4.89e-01 5.34e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 7.47e-01 8.34e-01 0.08190 -3.64e-02 0.073400 8.35e-01 6.73e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 6.87e-01 7.94e-01 0.08180 -6.15e-02 -0.053900 4.06e-01 4.66e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 5.08e-01 6.64e-01 0.08130 5.12e-02 -0.063100 6.64e-01 5.92e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 8.49e-01 9.01e-01 0.08110 -6.75e-02 -0.044800 5.67e-01 7.04e-01
ENDOGENOUS STEROLS 20 6.65e-01 7.79e-01 0.08050 -7.95e-02 0.012900 5.38e-01 9.21e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 8.96e-01 9.35e-01 0.08030 -5.07e-02 -0.062300 7.10e-01 6.47e-01
CARDIAC CONDUCTION 107 5.29e-02 1.45e-01 0.08030 -6.14e-02 0.051700 2.72e-01 3.56e-01
DISEASES OF MITOTIC CELL CYCLE 37 8.07e-01 8.72e-01 0.07980 5.79e-02 0.054900 5.42e-01 5.63e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 9.03e-01 9.37e-01 0.07920 2.41e-02 0.075400 8.95e-01 6.80e-01
SIGNALING BY FGFR2 IIIA TM 19 8.61e-01 9.10e-01 0.07870 -3.42e-02 -0.070900 7.97e-01 5.93e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 2.75e-01 4.49e-01 0.07840 7.80e-02 0.008340 1.92e-01 8.89e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 5.10e-01 6.67e-01 0.07840 7.09e-02 0.033500 2.59e-01 5.93e-01
POTASSIUM CHANNELS 90 5.55e-01 7.02e-01 0.07810 6.62e-02 0.041500 2.78e-01 4.96e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 9.11e-01 9.43e-01 0.07760 -6.44e-02 -0.043200 6.66e-01 7.72e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 8.21e-01 8.82e-01 0.07750 5.68e-02 0.052700 5.55e-01 5.85e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 7.31e-01 8.23e-01 0.07740 -3.63e-02 0.068400 8.21e-01 6.69e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 12 7.75e-01 8.51e-01 0.07710 2.27e-02 -0.073700 8.92e-01 6.59e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 110 4.22e-01 5.84e-01 0.07700 -3.17e-02 -0.070200 5.66e-01 2.04e-01
REGULATED NECROSIS 46 3.57e-01 5.25e-01 0.07690 2.90e-02 -0.071200 7.34e-01 4.03e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 8.07e-01 8.72e-01 0.07680 1.36e-02 0.075600 9.20e-01 5.79e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 6.70e-01 7.84e-01 0.07680 -1.94e-04 0.076800 9.99e-01 4.98e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 7.64e-01 8.45e-01 0.07650 7.59e-02 0.009530 5.47e-01 9.40e-01
MRNA SPLICING 188 9.65e-03 4.19e-02 0.07630 4.90e-02 -0.058500 2.47e-01 1.67e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 150 2.70e-02 9.01e-02 0.07630 4.20e-02 -0.063700 3.75e-01 1.78e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.72e-01 9.15e-01 0.07510 -7.06e-02 -0.025700 6.25e-01 8.59e-01
FGFR2 ALTERNATIVE SPLICING 25 6.37e-01 7.58e-01 0.07480 1.38e-02 -0.073500 9.05e-01 5.24e-01
FOXO MEDIATED TRANSCRIPTION 57 4.73e-01 6.32e-01 0.07400 -7.39e-02 -0.004470 3.35e-01 9.53e-01
FRS MEDIATED FGFR2 SIGNALING 19 8.45e-01 9.00e-01 0.07330 -2.15e-02 -0.070100 8.71e-01 5.97e-01
INSULIN RECEPTOR SIGNALLING CASCADE 46 3.86e-01 5.47e-01 0.07330 -2.95e-02 0.067100 7.29e-01 4.31e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 5.82e-01 7.21e-01 0.07270 3.71e-02 -0.062500 7.48e-01 5.89e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 8.06e-01 8.72e-01 0.07200 3.45e-03 0.072000 9.80e-01 6.08e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 8.99e-01 9.37e-01 0.07200 1.20e-02 0.071000 9.48e-01 6.97e-01
APOPTOTIC EXECUTION PHASE 45 8.11e-01 8.74e-01 0.07130 5.33e-02 0.047400 5.36e-01 5.82e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 9.38e-01 9.62e-01 0.07120 5.15e-02 0.049200 7.39e-01 7.50e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 8.28e-01 8.86e-01 0.07120 -1.05e-02 0.070400 9.50e-01 6.73e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 6.29e-01 7.52e-01 0.07100 -6.31e-02 0.032600 6.00e-01 7.87e-01
UCH PROTEINASES 89 1.53e-01 3.04e-01 0.07060 5.65e-02 -0.042400 3.57e-01 4.90e-01
POTENTIAL THERAPEUTICS FOR SARS 77 6.10e-01 7.40e-01 0.07060 6.38e-02 0.030200 3.33e-01 6.46e-01
CHROMOSOME MAINTENANCE 104 5.21e-01 6.76e-01 0.07050 -3.09e-02 -0.063400 5.86e-01 2.65e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.76e-01 7.86e-01 0.07020 -6.85e-02 -0.015000 4.42e-01 8.66e-01
DUAL INCISION IN TC NER 65 6.60e-01 7.76e-01 0.06980 -6.34e-02 -0.029200 3.77e-01 6.84e-01
VOLTAGE GATED POTASSIUM CHANNELS 38 8.24e-01 8.83e-01 0.06960 3.78e-02 0.058400 6.87e-01 5.34e-01
CYTOPROTECTION BY HMOX1 119 8.75e-02 2.07e-01 0.06920 4.75e-02 -0.050200 3.71e-01 3.44e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 46 6.71e-01 7.84e-01 0.06900 -1.64e-02 -0.067000 8.48e-01 4.32e-01
SUMOYLATION 168 3.62e-02 1.13e-01 0.06870 -5.55e-02 0.040400 2.15e-01 3.66e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 66 5.28e-01 6.81e-01 0.06830 -1.07e-02 -0.067500 8.80e-01 3.43e-01
HCMV EARLY EVENTS 83 6.71e-01 7.84e-01 0.06760 3.68e-02 0.056700 5.63e-01 3.72e-01
HATS ACETYLATE HISTONES 96 3.08e-01 4.81e-01 0.06750 -6.74e-02 0.001970 2.54e-01 9.73e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 7.62e-01 8.43e-01 0.06690 6.51e-02 -0.015600 6.33e-01 9.09e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 11 9.55e-01 9.72e-01 0.06600 -4.07e-02 -0.052000 8.15e-01 7.65e-01
COMPLEMENT CASCADE 26 9.02e-01 9.37e-01 0.06570 4.97e-02 0.042900 6.61e-01 7.05e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 8.73e-01 9.15e-01 0.06540 3.01e-02 0.058000 7.91e-01 6.08e-01
PHOSPHORYLATION OF THE APC C 17 9.15e-01 9.45e-01 0.06540 5.82e-02 0.029700 6.78e-01 8.32e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 33 5.51e-01 7.02e-01 0.06520 -3.98e-02 0.051600 6.93e-01 6.08e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 9.09e-01 9.41e-01 0.06450 6.31e-02 0.013400 7.05e-01 9.36e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 7.82e-01 8.55e-01 0.06430 3.68e-02 0.052800 6.25e-01 4.84e-01
STIMULI SENSING CHANNELS 76 2.64e-01 4.35e-01 0.06390 -4.36e-02 0.046800 5.11e-01 4.81e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 604 8.22e-04 7.38e-03 0.06370 6.33e-02 -0.007420 8.15e-03 7.56e-01
P75NTR SIGNALS VIA NF KB 15 8.68e-01 9.13e-01 0.06360 -5.07e-03 -0.063400 9.73e-01 6.71e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 541 1.61e-03 1.23e-02 0.06350 -8.11e-03 0.063000 7.48e-01 1.25e-02
G2 M CHECKPOINTS 136 1.69e-01 3.21e-01 0.06300 6.15e-02 -0.013500 2.16e-01 7.85e-01
TRNA PROCESSING 105 4.18e-01 5.81e-01 0.06260 8.87e-03 0.062000 8.75e-01 2.73e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 2.31e-01 4.01e-01 0.06250 6.02e-02 -0.016900 2.80e-01 7.62e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 9.13e-01 9.45e-01 0.06250 -4.05e-02 -0.047600 7.26e-01 6.81e-01
SEMAPHORIN INTERACTIONS 64 6.29e-01 7.52e-01 0.06250 -6.09e-02 -0.014000 4.00e-01 8.46e-01
PYRIMIDINE CATABOLISM 10 9.02e-01 9.37e-01 0.06200 1.31e-03 -0.062000 9.94e-01 7.34e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 7.14e-01 8.12e-01 0.06160 -5.06e-02 -0.035200 4.12e-01 5.68e-01
SIGNALING BY FGFR 74 5.82e-01 7.21e-01 0.06100 5.99e-02 0.011700 3.73e-01 8.62e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 1.87e-01 3.47e-01 0.06040 -4.57e-02 0.039400 4.12e-01 4.79e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 6.48e-01 7.67e-01 0.05950 2.08e-02 -0.055800 8.37e-01 5.79e-01
DNA REPAIR 295 1.27e-01 2.70e-01 0.05900 -5.81e-02 -0.009910 8.63e-02 7.70e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.91e-01 9.30e-01 0.05860 -1.36e-02 0.057000 9.41e-01 7.55e-01
ANTIGEN PROCESSING CROSS PRESENTATION 96 3.61e-01 5.27e-01 0.05850 5.78e-02 -0.008870 3.28e-01 8.81e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 4.59e-01 6.20e-01 0.05690 -2.20e-02 0.052500 7.63e-01 4.71e-01
EXTENSION OF TELOMERES 49 8.47e-01 9.00e-01 0.05600 2.95e-02 0.047600 7.21e-01 5.64e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.47e-01 2.95e-01 0.05520 1.87e-02 -0.052000 6.72e-01 2.40e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 8.66e-01 9.12e-01 0.05500 -2.20e-02 -0.050400 8.22e-01 6.06e-01
DUAL INCISION IN GG NER 41 7.46e-01 8.34e-01 0.05500 -5.48e-02 -0.003870 5.44e-01 9.66e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 8.48e-01 9.01e-01 0.05420 4.80e-02 -0.025200 7.56e-01 8.70e-01
TP53 REGULATES METABOLIC GENES 85 6.35e-01 7.56e-01 0.05320 -1.14e-02 -0.051900 8.56e-01 4.08e-01
ELASTIC FIBRE FORMATION 38 6.32e-01 7.54e-01 0.05310 -3.95e-02 0.035500 6.74e-01 7.05e-01
SIGNALING BY FGFR2 63 6.73e-01 7.84e-01 0.05270 5.25e-02 0.005300 4.72e-01 9.42e-01
ANTIMICROBIAL PEPTIDES 15 9.49e-01 9.68e-01 0.05220 2.24e-02 0.047100 8.80e-01 7.52e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 9.29e-01 9.58e-01 0.05170 2.43e-02 0.045600 8.40e-01 7.05e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 7.13e-01 8.12e-01 0.05130 -2.15e-02 0.046500 8.31e-01 6.44e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 3.84e-01 5.46e-01 0.05050 4.56e-02 -0.021700 4.41e-01 7.13e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 20 8.33e-01 8.90e-01 0.04930 4.60e-02 -0.017900 7.22e-01 8.90e-01
RHO GTPASES ACTIVATE PAKS 21 8.17e-01 8.80e-01 0.04890 4.31e-02 -0.023100 7.33e-01 8.55e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 7.34e-01 8.25e-01 0.04880 -4.62e-03 -0.048600 9.52e-01 5.26e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 8.64e-01 9.12e-01 0.04850 2.62e-02 -0.040800 8.60e-01 7.85e-01
SURFACTANT METABOLISM 16 9.26e-01 9.55e-01 0.04810 4.75e-02 0.007400 7.42e-01 9.59e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 7.79e-01 8.55e-01 0.04740 1.81e-02 0.043800 7.81e-01 5.01e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 7.15e-01 8.12e-01 0.04560 1.82e-03 -0.045500 9.81e-01 5.45e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 6.87e-01 7.94e-01 0.04530 -1.75e-02 0.041800 8.34e-01 6.17e-01
MRNA CAPPING 29 9.41e-01 9.64e-01 0.04470 3.75e-02 0.024300 7.27e-01 8.21e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 8.20e-01 8.82e-01 0.04430 -8.64e-03 0.043500 9.34e-01 6.75e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 9.25e-01 9.55e-01 0.04420 6.06e-03 -0.043800 9.70e-01 7.85e-01
EXTRACELLULAR MATRIX ORGANIZATION 250 4.82e-01 6.42e-01 0.04360 -4.12e-02 -0.014300 2.62e-01 6.98e-01
SIGNALING BY NUCLEAR RECEPTORS 228 6.85e-01 7.92e-01 0.04310 3.09e-02 0.030000 4.23e-01 4.36e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 5.85e-01 7.22e-01 0.04290 -3.85e-02 0.018900 5.67e-01 7.79e-01
METABOLISM OF RNA 644 8.64e-03 3.84e-02 0.04280 2.37e-02 -0.035700 3.06e-01 1.24e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 8.53e-01 9.04e-01 0.04280 -1.34e-02 0.040600 9.09e-01 7.31e-01
REGULATION OF BETA CELL DEVELOPMENT 30 9.32e-01 9.60e-01 0.04270 -3.85e-02 -0.018400 7.15e-01 8.62e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 6.62e-01 7.77e-01 0.04270 -3.63e-02 0.022400 6.41e-01 7.74e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 8.65e-01 9.12e-01 0.04240 -4.07e-02 0.011700 7.35e-01 9.22e-01
MRNA SPLICING MINOR PATHWAY 52 6.77e-01 7.86e-01 0.04210 3.34e-02 -0.025500 6.77e-01 7.50e-01
SIGNALING BY PDGFR IN DISEASE 20 9.01e-01 9.37e-01 0.04180 -4.65e-03 0.041500 9.71e-01 7.48e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 50 8.90e-01 9.30e-01 0.04160 -3.81e-02 -0.016700 6.41e-01 8.38e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 9.03e-01 9.37e-01 0.04150 4.08e-02 0.007730 6.99e-01 9.42e-01
DNA DOUBLE STRAND BREAK RESPONSE 55 8.45e-01 9.00e-01 0.04130 1.02e-02 0.040000 8.96e-01 6.08e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 7.82e-01 8.55e-01 0.04130 7.34e-03 0.040600 9.14e-01 5.51e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 9.33e-01 9.60e-01 0.04110 3.89e-02 0.013100 7.31e-01 9.08e-01
SIGNALING BY ERYTHROPOIETIN 24 8.56e-01 9.06e-01 0.04080 -3.70e-02 0.017200 7.54e-01 8.84e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 2.04e-01 3.65e-01 0.04070 3.49e-02 -0.020900 3.56e-01 5.80e-01
CA2 PATHWAY 59 6.58e-01 7.74e-01 0.04060 2.98e-02 -0.027600 6.92e-01 7.14e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 7.12e-01 8.11e-01 0.03940 3.92e-02 -0.004160 5.60e-01 9.51e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 9.65e-01 9.79e-01 0.03940 -3.50e-02 -0.018100 7.92e-01 8.92e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 7.43e-01 8.33e-01 0.03920 -3.35e-02 0.020300 6.91e-01 8.09e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 9.48e-01 9.68e-01 0.03700 3.55e-02 -0.010800 8.39e-01 9.51e-01
NONHOMOLOGOUS END JOINING NHEJ 46 9.42e-01 9.64e-01 0.03690 -2.90e-02 -0.022800 7.34e-01 7.89e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 9.33e-01 9.60e-01 0.03570 -3.53e-02 -0.005690 7.55e-01 9.60e-01
SIGNALING BY NOTCH 192 6.42e-01 7.60e-01 0.03490 3.42e-02 0.007250 4.15e-01 8.63e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 8.72e-01 9.15e-01 0.03470 1.02e-02 -0.033100 9.21e-01 7.46e-01
SIGNALING BY PDGF 56 8.44e-01 9.00e-01 0.03460 -3.46e-02 -0.000670 6.54e-01 9.93e-01
HIV TRANSCRIPTION INITIATION 45 8.11e-01 8.74e-01 0.03410 -3.02e-02 0.015900 7.26e-01 8.54e-01
NUCLEOTIDE EXCISION REPAIR 110 7.84e-01 8.57e-01 0.03240 3.20e-02 0.004640 5.62e-01 9.33e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.42e-01 9.64e-01 0.03220 -3.04e-02 -0.010500 7.49e-01 9.12e-01
IRAK1 RECRUITS IKK COMPLEX 14 9.86e-01 9.93e-01 0.03210 2.01e-02 0.025100 8.96e-01 8.71e-01
MITOCHONDRIAL BIOGENESIS 92 7.46e-01 8.34e-01 0.03100 -3.02e-02 0.006880 6.17e-01 9.09e-01
SIGNALING BY ERBB2 IN CANCER 25 9.75e-01 9.89e-01 0.03070 1.65e-02 0.026000 8.87e-01 8.22e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 9.84e-01 9.92e-01 0.02980 2.21e-02 0.020000 8.64e-01 8.77e-01
FRS MEDIATED FGFR1 SIGNALING 18 9.36e-01 9.61e-01 0.02960 2.44e-02 -0.016800 8.58e-01 9.02e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 9.55e-01 9.72e-01 0.02950 2.93e-02 -0.003190 8.29e-01 9.81e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 9.79e-01 9.90e-01 0.02750 2.58e-02 0.009600 8.46e-01 9.42e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 9.52e-01 9.71e-01 0.02610 2.00e-02 0.016800 7.61e-01 7.98e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 9.46e-01 9.67e-01 0.02580 1.36e-02 0.021900 8.36e-01 7.38e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.98e-01 9.37e-01 0.02500 -1.43e-02 0.020400 8.74e-01 8.21e-01
NERVOUS SYSTEM DEVELOPMENT 553 3.42e-01 5.12e-01 0.02310 2.15e-02 -0.008450 3.90e-01 7.35e-01
METALLOPROTEASE DUBS 26 9.55e-01 9.72e-01 0.02230 2.12e-02 -0.006720 8.51e-01 9.53e-01
SENSORY PROCESSING OF SOUND 62 9.59e-01 9.74e-01 0.02230 -8.79e-03 -0.020500 9.05e-01 7.80e-01
DEVELOPMENTAL BIOLOGY 830 2.94e-01 4.65e-01 0.02160 4.70e-03 -0.021100 8.19e-01 3.05e-01
DAP12 SIGNALING 24 9.90e-01 9.94e-01 0.02140 -1.62e-02 -0.013900 8.91e-01 9.06e-01
RNA POLYMERASE II TRANSCRIPTION 1097 2.93e-01 4.65e-01 0.02010 -2.00e-02 0.002000 2.66e-01 9.12e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 9.57e-01 9.72e-01 0.01930 -1.24e-02 0.014700 9.10e-01 8.93e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 9.86e-01 9.93e-01 0.01930 1.91e-02 0.002210 8.91e-01 9.87e-01
ARACHIDONIC ACID METABOLISM 38 9.83e-01 9.92e-01 0.01920 8.79e-03 0.017100 9.25e-01 8.55e-01
TRANSCRIPTIONAL REGULATION BY TP53 343 8.70e-01 9.14e-01 0.01610 4.98e-03 0.015300 8.74e-01 6.27e-01
SYNDECAN INTERACTIONS 27 9.92e-01 9.96e-01 0.01430 1.32e-02 0.005410 9.05e-01 9.61e-01
ESR MEDIATED SIGNALING 171 8.66e-01 9.12e-01 0.01400 1.05e-02 -0.009340 8.13e-01 8.33e-01
PERK REGULATES GENE EXPRESSION 28 9.78e-01 9.90e-01 0.01360 1.10e-02 -0.007930 9.19e-01 9.42e-01
SIGNALING BY FGFR IN DISEASE 57 9.80e-01 9.90e-01 0.01270 -1.26e-02 -0.001460 8.69e-01 9.85e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 9.97e-01 9.97e-01 0.01120 5.72e-03 0.009660 9.62e-01 9.36e-01
TRANSCRIPTION OF THE HIV GENOME 67 9.89e-01 9.94e-01 0.01060 9.87e-03 0.003950 8.89e-01 9.55e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 9.93e-01 9.96e-01 0.00983 -3.19e-03 0.009300 9.81e-01 9.44e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.97e-01 9.97e-01 0.00978 -5.65e-03 -0.007990 9.58e-01 9.41e-01
CELLULAR SENESCENCE 144 9.76e-01 9.89e-01 0.00871 1.00e-03 0.008650 9.83e-01 8.58e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.88e-01 9.94e-01 0.00588 5.09e-03 -0.002940 9.35e-01 9.63e-01
AURKA ACTIVATION BY TPX2 71 9.97e-01 9.97e-01 0.00319 -2.97e-03 0.001150 9.65e-01 9.87e-01


Detailed Gene set reports


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
metric value
setSize 12
pMANOVA 0.000955
p.adjustMANOVA 0.0082
s.dist 0.784
s.LPS 0.608
s.OVA 0.494
p.LPS 0.000264
p.OVA 0.00303



Top 20 genes
Gene LPS OVA
Fads2 8261 8470
Fads1 8175 7161
Hsd17b4 6524 8886
Acox1 6027 8680
Elovl1 7423 6274
Elovl2 2599 8770
Acsl1 2701 7510
Scp2 3784 4258
Elovl5 2618 6090

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All member genes
LPS OVA
Abcd1 1854 -4216
Acaa1a 5255 -514
Acot8 3522 -2843
Acox1 6027 8680
Acsl1 2701 7510
Elovl1 7423 6274
Elovl2 2599 8770
Elovl5 2618 6090
Fads1 8175 7161
Fads2 8261 8470
Hsd17b4 6524 8886
Scp2 3784 4258



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 2.42e-07
p.adjustMANOVA 9.82e-06
s.dist 0.777
s.LPS 0.707
s.OVA 0.32
p.LPS 9.34e-08
p.OVA 0.0156



Top 20 genes
Gene LPS OVA
Cct6a 8085 8933
Tubb2b 7454 8823
Tcp1 6594 8066
Cct3 7102 6549
Cct5 7278 5983
Tubb2a 8077 4594
Tuba1b 7821 4725
Cct4 6209 5468
Tuba4a 7160 3678
Tubb4a 7467 3033
Cct8 6442 3134
Cct7 4810 3668
Tubb4b 7572 2013
Cct2 3805 3760
Tuba1a 7019 1823

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All member genes
LPS OVA
Cct2 3805 3760
Cct3 7102 6549
Cct4 6209 5468
Cct5 7278 5983
Cct6a 8085 8933
Cct7 4810 3668
Cct8 6442 3134
Tcp1 6594 8066
Tuba1a 7019 1823
Tuba1b 7821 4725
Tuba1c 4455 -1804
Tuba4a 7160 3678
Tuba8 -5538 -1625
Tubb2a 8077 4594
Tubb2b 7454 8823
Tubb3 5805 -2350
Tubb4a 7467 3033
Tubb4b 7572 2013
Tubb6 1795 -4655



PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
metric value
setSize 12
pMANOVA 0.00227
p.adjustMANOVA 0.015
s.dist 0.741
s.LPS 0.56
s.OVA 0.486
p.LPS 0.00079
p.OVA 0.00358



Top 20 genes
Gene LPS OVA
Paics 7023 9071
Gart 7333 7646
Atic 6667 7906
Impdh2 7541 6136
Adss 6879 6719
Adsl 5387 7748
Gmps 6736 3069
Adssl1 5310 2672
Impdh1 3107 3845
Ppat 1906 4976
Lhpp 1153 2706

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All member genes
LPS OVA
Adsl 5387 7748
Adss 6879 6719
Adssl1 5310 2672
Atic 6667 7906
Gart 7333 7646
Gmps 6736 3069
Impdh1 3107 3845
Impdh2 7541 6136
Lhpp 1153 2706
Paics 7023 9071
Pfas -5398 -4864
Ppat 1906 4976



RHOBTB3 ATPASE CYCLE
RHOBTB3 ATPASE CYCLE
metric value
setSize 10
pMANOVA 0.00723
p.adjustMANOVA 0.0334
s.dist 0.729
s.LPS 0.553
s.OVA 0.475
p.LPS 0.00244
p.OVA 0.00932



Top 20 genes
Gene LPS OVA
Htr7 7842 9008
Cul3 5785 8121
Lrrc41 4555 7806
Plin3 5229 6668
Hgs 5304 5802
Rab9b 5886 4359
Vhl 2241 2567
Rhobtb3 398 6658

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All member genes
LPS OVA
Ccne1 7381 -2653
Cul3 5785 8121
Hgs 5304 5802
Htr7 7842 9008
Lrrc41 4555 7806
Plin3 5229 6668
Rab9 -453 -1251
Rab9b 5886 4359
Rhobtb3 398 6658
Vhl 2241 2567



CITRIC ACID CYCLE TCA CYCLE
CITRIC ACID CYCLE TCA CYCLE
metric value
setSize 22
pMANOVA 3.58e-05
p.adjustMANOVA 0.000657
s.dist 0.716
s.LPS 0.511
s.OVA 0.502
p.LPS 3.38e-05
p.OVA 4.56e-05



Top 20 genes
Gene LPS OVA
Fh1 7863 9041
Idh3a 7936 8737
Idh2 8195 7982
Dld 6858 8590
Sucla2 6880 7731
Idh3b 6612 7636
Suclg2 5301 8528
Aco2 4697 8516
Dlst 6428 6201
Sdha 3976 6855
Sdhd 5044 4958
Idh3g 4269 4955
Cs 3812 5377
Ogdh 3632 4631
Mdh2 5289 2239
Sdhb 2153 1641
Suclg1 3532 979
Nnt 1702 1605
Sdhc 1188 1344

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All member genes
LPS OVA
Aco2 4697 8516
Cs 3812 5377
Dld 6858 8590
Dlst 6428 6201
Fahd1 1718 -3997
Fh1 7863 9041
Idh2 8195 7982
Idh3a 7936 8737
Idh3b 6612 7636
Idh3g 4269 4955
Mdh2 5289 2239
Me2 -3382 6183
Me3 -4813 -982
Nnt 1702 1605
Ogdh 3632 4631
Sdha 3976 6855
Sdhb 2153 1641
Sdhc 1188 1344
Sdhd 5044 4958
Sucla2 6880 7731
Suclg1 3532 979
Suclg2 5301 8528



BBSOME MEDIATED CARGO TARGETING TO CILIUM
BBSOME MEDIATED CARGO TARGETING TO CILIUM
metric value
setSize 23
pMANOVA 2.81e-05
p.adjustMANOVA 0.000533
s.dist 0.7
s.LPS 0.534
s.OVA 0.453
p.LPS 9.29e-06
p.OVA 0.000172



Top 20 genes
Gene LPS OVA
Lztfl1 6460 8899
Mkks 7976 7175
Tcp1 6594 8066
Mchr1 7207 7350
Arl6 6928 7336
Cct3 7102 6549
Bbs10 7829 5568
Cct5 7278 5983
Rab3ip 6181 7022
Bbs1 5888 7036
Ttc8 6131 5690
Cct4 6209 5468
Bbs7 4486 6358
Smo 5019 5076
Cct8 6442 3134
Cct2 3805 3760
Bbs4 1645 5488
Bbs2 2148 307

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All member genes
LPS OVA
Arl6 6928 7336
Bbip1 1824 -684
Bbs1 5888 7036
Bbs10 7829 5568
Bbs12 -5743 -115
Bbs2 2148 307
Bbs4 1645 5488
Bbs5 -5658 -4835
Bbs7 4486 6358
Bbs9 7186 -196
Cct2 3805 3760
Cct3 7102 6549
Cct4 6209 5468
Cct5 7278 5983
Cct8 6442 3134
Lztfl1 6460 8899
Mchr1 7207 7350
Mkks 7976 7175
Rab3ip 6181 7022
Smo 5019 5076
Sstr3 -5330 3302
Tcp1 6594 8066
Ttc8 6131 5690



OLFACTORY SIGNALING PATHWAY
OLFACTORY SIGNALING PATHWAY
metric value
setSize 37
pMANOVA 1.31e-07
p.adjustMANOVA 5.93e-06
s.dist 0.686
s.LPS -0.472
s.OVA -0.499
p.LPS 6.84e-07
p.OVA 1.53e-07



Top 20 genes
Gene LPS OVA
Olfr981 -9068 -8167
Olfr354 -9004 -8150
Olfr1310 -8829 -8166
Olfr635 -8905 -7900
Olfr1192-ps1 -8765 -8005
Olfr1309 -8264 -7778
Olfr796 -8485 -7181
Olfr986 -8019 -7504
Olfr63 -8275 -7039
Olfr90 -7288 -7907
Olfr1564 -8451 -6488
Olfr78 -7251 -6813
Olfr804 -6661 -7412
Gng13 -6572 -7495
Olfr2 -8410 -5777
Olfr1385 -6485 -7474
Olfr735 -8350 -5750
Rtp4 -9123 -4991
Olfr161 -5808 -7314
Olfr365 -5416 -7297

Click HERE to show all gene set members

All member genes
LPS OVA
Gnal 4210 3997
Gnb1 6309 4849
Gng13 -6572 -7495
Olfr1192-ps1 -8765 -8005
Olfr1309 -8264 -7778
Olfr1310 -8829 -8166
Olfr137 -5410 -1229
Olfr1385 -6485 -7474
Olfr147 -3185 -3019
Olfr1507 -581 -6842
Olfr1564 -8451 -6488
Olfr161 -5808 -7314
Olfr2 -8410 -5777
Olfr287 -7623 473
Olfr31 -6707 -5395
Olfr354 -9004 -8150
Olfr365 -5416 -7297
Olfr552 349 -1371
Olfr558 -2444 -7213
Olfr63 -8275 -7039
Olfr635 -8905 -7900
Olfr648 -4351 1868
Olfr735 -8350 -5750
Olfr78 -7251 -6813
Olfr796 -8485 -7181
Olfr804 -6661 -7412
Olfr90 -7288 -7907
Olfr95 311 -2936
Olfr981 -9068 -8167
Olfr986 -8019 -7504
Reep1 2393 6990
Reep2 5088 3118
Reep3 -344 5266
Reep4 -4399 -271
Reep5 6836 6530
Reep6 -575 -268
Rtp4 -9123 -4991



CALNEXIN CALRETICULIN CYCLE
CALNEXIN CALRETICULIN CYCLE
metric value
setSize 26
pMANOVA 3.25e-05
p.adjustMANOVA 0.000607
s.dist 0.661
s.LPS 0.455
s.OVA 0.48
p.LPS 5.89e-05
p.OVA 2.31e-05



Top 20 genes
Gene LPS OVA
Derl2 8155 9168
Pdia3 7836 8348
Ganab 7242 8914
Man1b1 6094 8607
Edem2 5600 9207
Os9 6543 7667
Calr 8166 5151
Amfr 5392 7797
Uggt1 5263 7777
Syvn1 5132 7943
Marchf6 5802 6991
Rnf139 5267 7108
Ubc 4470 5873
Edem3 2257 6455
Rnf185 6658 2122
Canx 6322 1742
Rnf5 5625 1022
Prkcsh 7664 96

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All member genes
LPS OVA
Amfr 5392 7797
Calr 8166 5151
Canx 6322 1742
Derl2 8155 9168
Edem1 -1052 5340
Edem2 5600 9207
Edem3 2257 6455
Ganab 7242 8914
Man1b1 6094 8607
Marchf6 5802 6991
Os9 6543 7667
Pdia3 7836 8348
Prkcsh 7664 96
Rnf103 -716 4987
Rnf139 5267 7108
Rnf185 6658 2122
Rnf5 5625 1022
Rps27a -474 -2054
Sel1l -2236 5034
Syvn1 5132 7943
Trim13 -2988 4143
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873
Uggt1 5263 7777
Uggt2 -2716 3830



GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
metric value
setSize 12
pMANOVA 0.00216
p.adjustMANOVA 0.0146
s.dist 0.646
s.LPS 0.575
s.OVA 0.295
p.LPS 0.000567
p.OVA 0.077



Top 20 genes
Gene LPS OVA
Uso1 6805 8727
Mapk1 7049 7970
Rab2a 6426 7199
Blzf1 4951 9002
Mapk3 7650 5141
Gorasp2 7490 4513
Rab1b 6273 4877
Ccnb2 5854 1126

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All member genes
LPS OVA
Blzf1 4951 9002
Ccnb2 5854 1126
Golga2 -3150 -2787
Gorasp1 4084 -243
Gorasp2 7490 4513
Mapk1 7049 7970
Mapk3 7650 5141
Plk1 -4312 -7780
Rab1a 6105 -112
Rab1b 6273 4877
Rab2a 6426 7199
Uso1 6805 8727



NUCLEOBASE BIOSYNTHESIS
NUCLEOBASE BIOSYNTHESIS
metric value
setSize 15
pMANOVA 0.00274
p.adjustMANOVA 0.0171
s.dist 0.637
s.LPS 0.507
s.OVA 0.385
p.LPS 0.000669
p.OVA 0.00991



Top 20 genes
Gene LPS OVA
Paics 7023 9071
Gart 7333 7646
Atic 6667 7906
Impdh2 7541 6136
Adss 6879 6719
Adsl 5387 7748
Umps 7638 4141
Gmps 6736 3069
Adssl1 5310 2672
Impdh1 3107 3845
Ppat 1906 4976
Lhpp 1153 2706
Dhodh 1001 140

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All member genes
LPS OVA
Adsl 5387 7748
Adss 6879 6719
Adssl1 5310 2672
Atic 6667 7906
Cad -2077 -3123
Dhodh 1001 140
Gart 7333 7646
Gmps 6736 3069
Impdh1 3107 3845
Impdh2 7541 6136
Lhpp 1153 2706
Paics 7023 9071
Pfas -5398 -4864
Ppat 1906 4976
Umps 7638 4141



RETROGRADE NEUROTROPHIN SIGNALLING
RETROGRADE NEUROTROPHIN SIGNALLING
metric value
setSize 13
pMANOVA 0.0103
p.adjustMANOVA 0.0442
s.dist 0.622
s.LPS 0.452
s.OVA 0.427
p.LPS 0.00476
p.OVA 0.00773



Top 20 genes
Gene LPS OVA
Dnm2 7564 9254
Ap2b1 7472 7369
Ap2a2 6936 7060
Ap2m1 7740 4087
Cltc 4453 6225
Ap2a1 6070 3853
Dnm3 2285 5966
Dnal4 7331 1853
Sh3gl2 2840 3275
Dnm1 807 4289

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All member genes
LPS OVA
Ap2a1 6070 3853
Ap2a2 6936 7060
Ap2b1 7472 7369
Ap2m1 7740 4087
Ap2s1 -3449 -4270
Clta 3533 -54
Cltc 4453 6225
Dnal4 7331 1853
Dnm1 807 4289
Dnm2 7564 9254
Dnm3 2285 5966
Ntrk1 -7661 6826
Sh3gl2 2840 3275



N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
metric value
setSize 35
pMANOVA 1.3e-05
p.adjustMANOVA 0.000289
s.dist 0.595
s.LPS 0.42
s.OVA 0.422
p.LPS 1.73e-05
p.OVA 1.53e-05



Top 20 genes
Gene LPS OVA
Derl2 8155 9168
Pdia3 7836 8348
Ganab 7242 8914
Ngly1 7666 7938
Mlec 7512 8004
Derl1 6434 8377
Man1b1 6094 8607
Edem2 5600 9207
Os9 6543 7667
Calr 8166 5151
Amfr 5392 7797
Uggt1 5263 7777
Syvn1 5132 7943
Marchf6 5802 6991
Rnf139 5267 7108
Vcp 7358 4451
Ubc 4470 5873
Rad23b 3808 4840
Edem3 2257 6455
Rnf185 6658 2122

Click HERE to show all gene set members

All member genes
LPS OVA
Amfr 5392 7797
Calr 8166 5151
Canx 6322 1742
Derl1 6434 8377
Derl2 8155 9168
Edem1 -1052 5340
Edem2 5600 9207
Edem3 2257 6455
Engase -6971 895
Ganab 7242 8914
Man1b1 6094 8607
Marchf6 5802 6991
Mlec 7512 8004
Mogs -3426 -2832
Ngly1 7666 7938
Os9 6543 7667
Pdia3 7836 8348
Prkcsh 7664 96
Psmc1 747 -3977
Rad23b 3808 4840
Rnf103 -716 4987
Rnf139 5267 7108
Rnf185 6658 2122
Rnf5 5625 1022
Rps27a -474 -2054
Sel1l -2236 5034
Syvn1 5132 7943
Trim13 -2988 4143
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873
Ubxn1 -2017 -2512
Uggt1 5263 7777
Uggt2 -2716 3830
Vcp 7358 4451



BRANCHED CHAIN AMINO ACID CATABOLISM
BRANCHED CHAIN AMINO ACID CATABOLISM
metric value
setSize 21
pMANOVA 0.000816
p.adjustMANOVA 0.00738
s.dist 0.592
s.LPS 0.359
s.OVA 0.47
p.LPS 0.00441
p.OVA 0.00019



Top 20 genes
Gene LPS OVA
Aldh6a1 7713 9173
Ivd 7447 8648
Dld 6858 8590
Hibadh 6468 7961
Echs1 5492 8280
Bckdhb 6529 6578
Acadsb 6348 6689
Bcat2 6012 6617
Acat1 4057 8168
Slc25a44 4891 6693
Hsd17b10 5144 3201
Mccc2 2535 5839
Bcat1 3779 2388

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All member genes
LPS OVA
Acad8 -947 7028
Acadsb 6348 6689
Acat1 4057 8168
Aldh6a1 7713 9173
Auh -1871 -1834
Bcat1 3779 2388
Bcat2 6012 6617
Bckdha 226 -1150
Bckdhb 6529 6578
Bckdk -3550 -1041
Dbt -1670 7164
Dld 6858 8590
Echs1 5492 8280
Hibadh 6468 7961
Hibch 3401 -65
Hsd17b10 5144 3201
Ivd 7447 8648
Mccc1 -6592 5296
Mccc2 2535 5839
Ppm1k -5214 -6229
Slc25a44 4891 6693



ER QUALITY CONTROL COMPARTMENT ERQC
ER QUALITY CONTROL COMPARTMENT ERQC
metric value
setSize 21
pMANOVA 0.000727
p.adjustMANOVA 0.00685
s.dist 0.591
s.LPS 0.349
s.OVA 0.477
p.LPS 0.00565
p.OVA 0.000156



Top 20 genes
Gene LPS OVA
Derl2 8155 9168
Man1b1 6094 8607
Edem2 5600 9207
Os9 6543 7667
Amfr 5392 7797
Uggt1 5263 7777
Syvn1 5132 7943
Marchf6 5802 6991
Rnf139 5267 7108
Ubc 4470 5873
Edem3 2257 6455
Rnf185 6658 2122
Rnf5 5625 1022

Click HERE to show all gene set members

All member genes
LPS OVA
Amfr 5392 7797
Derl2 8155 9168
Edem1 -1052 5340
Edem2 5600 9207
Edem3 2257 6455
Man1b1 6094 8607
Marchf6 5802 6991
Os9 6543 7667
Rnf103 -716 4987
Rnf139 5267 7108
Rnf185 6658 2122
Rnf5 5625 1022
Rps27a -474 -2054
Sel1l -2236 5034
Syvn1 5132 7943
Trim13 -2988 4143
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873
Uggt1 5263 7777
Uggt2 -2716 3830



SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
metric value
setSize 20
pMANOVA 0.00206
p.adjustMANOVA 0.0142
s.dist 0.582
s.LPS 0.397
s.OVA 0.426
p.LPS 0.0021
p.OVA 0.000974



Top 20 genes
Gene LPS OVA
Acsbg1 7586 9139
Hsd17b12 7581 7845
Acsl4 7696 7303
Acsl6 6010 8414
Elovl1 7423 6274
Hacd2 6471 7159
Elovl4 5813 6543
Acsl3 4248 8897
Elovl2 2599 8770
Acsl1 2701 7510
Acsl5 4883 3724
Elovl5 2618 6090
Elovl6 2846 3667
Hacd3 5844 1133

Click HERE to show all gene set members

All member genes
LPS OVA
Acsbg1 7586 9139
Acsf3 -1804 4009
Acsl1 2701 7510
Acsl3 4248 8897
Acsl4 7696 7303
Acsl5 4883 3724
Acsl6 6010 8414
Elovl1 7423 6274
Elovl2 2599 8770
Elovl4 5813 6543
Elovl5 2618 6090
Elovl6 2846 3667
Elovl7 -8038 -5826
Hacd1 -8674 -5353
Hacd2 6471 7159
Hacd3 5844 1133
Hacd4 -3844 6672
Hsd17b12 7581 7845
Slc27a3 2106 -2373
Tecr 6970 -4007



LDL CLEARANCE
LDL CLEARANCE
metric value
setSize 16
pMANOVA 0.00781
p.adjustMANOVA 0.0351
s.dist 0.57
s.LPS 0.437
s.OVA 0.365
p.LPS 0.00246
p.OVA 0.0114



Top 20 genes
Gene LPS OVA
Lipa 8178 7907
Soat1 6666 8803
Ap2b1 7472 7369
Ap2a2 6936 7060
Npc1 7173 6328
Nceh1 5521 7620
Ap2m1 7740 4087
Cltc 4453 6225
Ap2a1 6070 3853
Lsr 739 3262

Click HERE to show all gene set members

All member genes
LPS OVA
Ap2a1 6070 3853
Ap2a2 6936 7060
Ap2b1 7472 7369
Ap2m1 7740 4087
Ap2s1 -3449 -4270
Clta 3533 -54
Cltc 4453 6225
Ldlr 1979 -1164
Ldlrap1 -6071 4838
Lipa 8178 7907
Lsr 739 3262
Nceh1 5521 7620
Npc1 7173 6328
Npc2 1615 -185
Pcsk9 -4132 -1688
Soat1 6666 8803



COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
metric value
setSize 44
pMANOVA 8.8e-08
p.adjustMANOVA 4.5e-06
s.dist 0.567
s.LPS 0.494
s.OVA 0.28
p.LPS 1.47e-08
p.OVA 0.00131



Top 20 genes
Gene LPS OVA
Tubb2b 7454 8823
Capza2 7653 8008
Dctn4 7129 8231
Rab6a 6536 8210
Rab3gap1 6032 7125
Dctn6 6421 6163
Pla2g4a 4615 8558
Tubb2a 8077 4594
Tuba1b 7821 4725
Actr1a 7339 4722
Galnt1 4202 8153
Dync1i1 5722 5693
Dctn1 6147 4919
Capza1 7205 4155
Pla2g6 5444 5372
Rab6b 5266 5276
Tuba4a 7160 3678
Tubb4a 7467 3033
Rab18 6493 3314
Galnt2 2743 6704

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All member genes
LPS OVA
Actr10 2946 5268
Actr1a 7339 4722
Agpat3 1974 7995
Bicd1 -3968 1924
Bicd2 -359 6316
Capza1 7205 4155
Capza2 7653 8008
Capzb 5172 2826
Dctn1 6147 4919
Dctn2 3294 2496
Dctn3 327 -3092
Dctn4 7129 8231
Dctn5 5397 -1095
Dctn6 6421 6163
Dync1h1 1330 2841
Dync1i1 5722 5693
Dync1i2 -3871 -3711
Dync1li1 2609 -771
Dync1li2 -3515 711
Dynll1 3588 -3373
Dynll2 -1874 -1448
Galnt1 4202 8153
Galnt2 2743 6704
Pafah1b1 2570 5228
Pafah1b2 2280 -2440
Pafah1b3 2869 -4348
Pla2g4a 4615 8558
Pla2g6 5444 5372
Rab18 6493 3314
Rab3gap1 6032 7125
Rab3gap2 2179 3920
Rab6a 6536 8210
Rab6b 5266 5276
Tuba1a 7019 1823
Tuba1b 7821 4725
Tuba1c 4455 -1804
Tuba4a 7160 3678
Tuba8 -5538 -1625
Tubb2a 8077 4594
Tubb2b 7454 8823
Tubb3 5805 -2350
Tubb4a 7467 3033
Tubb4b 7572 2013
Tubb6 1795 -4655



GLYCOSPHINGOLIPID METABOLISM
GLYCOSPHINGOLIPID METABOLISM
metric value
setSize 38
pMANOVA 1.56e-05
p.adjustMANOVA 0.000323
s.dist 0.567
s.LPS 0.407
s.OVA 0.395
p.LPS 1.44e-05
p.OVA 2.57e-05



Top 20 genes
Gene LPS OVA
B3galnt1 7997 9137
Galc 7162 8790
Arsa 6692 8889
B4galnt1 7700 7388
Asah1 6583 8559
Arsb 6679 8194
Esyt1 6539 8359
Gba2 6741 7374
Neu4 5715 8437
Ugt8a 7398 6299
Gla 4878 9109
Gltp 6270 5960
Neu1 6664 5371
Neu2 6964 5099
Psap 5604 6262
Gm2a 6046 4990
Gba 5519 3987
Neu3 2468 8852
Hexb 4272 4685
Ugcg 2950 6252

Click HERE to show all gene set members

All member genes
LPS OVA
Arsa 6692 8889
Arsb 6679 8194
Arsg -3285 3766
Arsj -2289 -3267
Arsk 1758 2988
Asah1 6583 8559
Asah2 -2407 -753
B3galnt1 7997 9137
B4galnt1 7700 7388
Cerk -4511 5187
Cptp -911 5040
Ctsa -2113 -3047
Esyt1 6539 8359
Esyt2 -6817 800
Esyt3 -117 -7279
Galc 7162 8790
Gba 5519 3987
Gba2 6741 7374
Gla 4878 9109
Glb1 2188 1249
Glb1l 548 4440
Gltp 6270 5960
Gm2a 6046 4990
Hexa 5596 -480
Hexb 4272 4685
Neu1 6664 5371
Neu2 6964 5099
Neu3 2468 8852
Neu4 5715 8437
Psap 5604 6262
Smpd1 6830 2471
Smpd2 -2796 -411
Smpd3 4172 2160
Smpd4 -2112 -3327
Sumf1 2198 672
Sumf2 2163 -146
Ugcg 2950 6252
Ugt8a 7398 6299



RECEPTOR MEDIATED MITOPHAGY
RECEPTOR MEDIATED MITOPHAGY
metric value
setSize 11
pMANOVA 0.0427
p.adjustMANOVA 0.126
s.dist 0.555
s.LPS 0.424
s.OVA 0.357
p.LPS 0.0149
p.OVA 0.0402



Top 20 genes
Gene LPS OVA
Fundc1 6661 8373
Atg12 6420 7411
Pgam5 2231 7190
Csnk2b 5030 3182
Src 2537 5624
Ulk1 4330 2726
Atg5 1469 7547
Map1lc3b 3513 2823

Click HERE to show all gene set members

All member genes
LPS OVA
Atg12 6420 7411
Atg5 1469 7547
Csnk2a1 -2720 -318
Csnk2a2 5839 -486
Csnk2b 5030 3182
Fundc1 6661 8373
Map1lc3a 854 -3576
Map1lc3b 3513 2823
Pgam5 2231 7190
Src 2537 5624
Ulk1 4330 2726



SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
metric value
setSize 10
pMANOVA 0.0622
p.adjustMANOVA 0.161
s.dist 0.548
s.LPS 0.414
s.OVA 0.359
p.LPS 0.0234
p.OVA 0.049



Top 20 genes
Gene LPS OVA
Itpk1 7870 9023
Ip6k3 7039 5497
Nudt11 7746 3972
Nudt4 3936 6702
Ip6k1 2807 6169
Nudt3 2727 91

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All member genes
LPS OVA
Ip6k1 2807 6169
Ip6k3 7039 5497
Ippk 605 -2213
Itpk1 7870 9023
Nudt10 5297 -2920
Nudt11 7746 3972
Nudt3 2727 91
Nudt4 3936 6702
Ppip5k1 -2532 4254
Ppip5k2 -3508 6432



ASPARTATE AND ASPARAGINE METABOLISM
ASPARTATE AND ASPARAGINE METABOLISM
metric value
setSize 10
pMANOVA 0.0438
p.adjustMANOVA 0.129
s.dist 0.548
s.LPS 0.302
s.OVA 0.457
p.LPS 0.0978
p.OVA 0.0124



Top 20 genes
Gene LPS OVA
Folh1 7926 9236
Slc25a12 6011 7235
Asns 5435 7781
Got2 6800 5915
Got1 4474 6347

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All member genes
LPS OVA
Asns 5435 7781
Aspa -4661 6618
Aspg -6201 1019
Folh1 7926 9236
Got1 4474 6347
Got2 6800 5915
Naalad2 5766 -1294
Nat8l 1219 -149
Slc25a12 6011 7235
Slc25a13 -4520 2789



TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
metric value
setSize 13
pMANOVA 0.000264
p.adjustMANOVA 0.00324
s.dist 0.54
s.LPS 0.535
s.OVA 0.0689
p.LPS 0.000835
p.OVA 0.667



Top 20 genes
Gene LPS OVA
Tubb2b 7454 8823
Tubb2a 8077 4594
Tuba1b 7821 4725
Tuba4a 7160 3678
Tubb4a 7467 3033
Gja1 5069 3862
Tubb4b 7572 2013
Tuba1a 7019 1823

Click HERE to show all gene set members

All member genes
LPS OVA
Gja1 5069 3862
Gjb2 -8816 -7002
Tuba1a 7019 1823
Tuba1b 7821 4725
Tuba1c 4455 -1804
Tuba4a 7160 3678
Tuba8 -5538 -1625
Tubb2a 8077 4594
Tubb2b 7454 8823
Tubb3 5805 -2350
Tubb4a 7467 3033
Tubb4b 7572 2013
Tubb6 1795 -4655



TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
metric value
setSize 12
pMANOVA 0.0381
p.adjustMANOVA 0.117
s.dist 0.537
s.LPS 0.417
s.OVA 0.339
p.LPS 0.0124
p.OVA 0.0419



Top 20 genes
Gene LPS OVA
Chmp3 7059 8270
Uvrag 5874 6872
Chmp2b 6303 4489
Chmp7 7103 3888
Pik3c3 3970 6884
Chmp4b 6002 4388
Pik3r4 2142 6152
Map1lc3b 3513 2823
Chmp6 1709 2687

Click HERE to show all gene set members

All member genes
LPS OVA
Becn1 6096 -943
Chmp2a -2624 -2850
Chmp2b 6303 4489
Chmp3 7059 8270
Chmp4b 6002 4388
Chmp4c -8459 -382
Chmp6 1709 2687
Chmp7 7103 3888
Map1lc3b 3513 2823
Pik3c3 3970 6884
Pik3r4 2142 6152
Uvrag 5874 6872



KERATAN SULFATE BIOSYNTHESIS
KERATAN SULFATE BIOSYNTHESIS
metric value
setSize 24
pMANOVA 5.51e-05
p.adjustMANOVA 0.000926
s.dist 0.536
s.LPS 0.497
s.OVA 0.201
p.LPS 2.54e-05
p.OVA 0.0879



Top 20 genes
Gene LPS OVA
B4galt4 8080 9233
B4gat1 7815 6655
Chst2 6862 7316
B3gnt2 6412 7769
St3gal4 5376 8530
Prelp 8253 3938
B4galt2 7005 4082
St3gal2 4771 5947
Chst1 5696 3434
Fmod 3990 4068
St3gal3 1860 8282
Chst5 1476 3786
B4galt3 2017 2092
Slc35d2 3247 880
B4galt5 1625 1347
B3gnt7 2805 562

Click HERE to show all gene set members

All member genes
LPS OVA
Acan 5225 -1263
B3gnt2 6412 7769
B3gnt4 4143 -2702
B3gnt7 2805 562
B4galt1 7158 -2643
B4galt2 7005 4082
B4galt3 2017 2092
B4galt4 8080 9233
B4galt5 1625 1347
B4galt6 4153 -2755
B4gat1 7815 6655
Chst1 5696 3434
Chst2 6862 7316
Chst5 1476 3786
Fmod 3990 4068
Lum 3365 -3697
Ogn -1917 -1341
Prelp 8253 3938
Slc35d2 3247 880
St3gal1 2411 -236
St3gal2 4771 5947
St3gal3 1860 8282
St3gal4 5376 8530
St3gal6 -7804 -7656



INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
metric value
setSize 13
pMANOVA 0.0151
p.adjustMANOVA 0.0577
s.dist 0.533
s.LPS 0.267
s.OVA 0.462
p.LPS 0.0961
p.OVA 0.00395



Top 20 genes
Gene LPS OVA
Tfdp1 8201 8324
Prim1 5137 7381
Pola2 5133 7073
Prim2 4274 8464
Ppp2ca 6292 5124
Ppp2r1a 5551 4599
Rb1 1666 7157
E2f1 1157 8445
Tfdp2 351 947

Click HERE to show all gene set members

All member genes
LPS OVA
E2f1 1157 8445
Pola1 -4350 5656
Pola2 5133 7073
Ppp2ca 6292 5124
Ppp2cb -500 -1856
Ppp2r1a 5551 4599
Ppp2r1b -4729 3965
Ppp2r3d -3327 -5575
Prim1 5137 7381
Prim2 4274 8464
Rb1 1666 7157
Tfdp1 8201 8324
Tfdp2 351 947



THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
metric value
setSize 27
pMANOVA 0.000739
p.adjustMANOVA 0.00691
s.dist 0.529
s.LPS 0.327
s.OVA 0.416
p.LPS 0.00327
p.OVA 0.000185



Top 20 genes
Gene LPS OVA
Ap1m1 7256 8999
Elmo1 7268 8749
Ap2b1 7472 7369
Ap1b1 6688 7892
Atp6v1h 6911 7530
Rac1 5983 8506
Pak2 5856 8623
Ap2a2 6936 7060
Fyn 4378 8562
Arf1 6829 4835
Ap2m1 7740 4087
Dock2 4145 6535
Ap2a1 6070 3853
Hck 3100 6686
Ap1m2 3486 5573
Ap1s1 5141 3721
Ap1s2 6207 2185
Pacs1 1481 4482
Lck 3266 1842
Ap1g1 1096 3839

Click HERE to show all gene set members

All member genes
LPS OVA
Ap1b1 6688 7892
Ap1g1 1096 3839
Ap1m1 7256 8999
Ap1m2 3486 5573
Ap1s1 5141 3721
Ap1s2 6207 2185
Ap1s3 -8420 -7035
Ap2a1 6070 3853
Ap2a2 6936 7060
Ap2b1 7472 7369
Ap2m1 7740 4087
Ap2s1 -3449 -4270
Arf1 6829 4835
Atp6v1h 6911 7530
B2m -7078 -114
Dock2 4145 6535
Elmo1 7268 8749
Fyn 4378 8562
H2-D1 -5007 -1998
H2-Q10 -6930 -2360
H2-Q2 -2894 7888
H2-Q7 -7706 40
Hck 3100 6686
Lck 3266 1842
Pacs1 1481 4482
Pak2 5856 8623
Rac1 5983 8506



WNT LIGAND BIOGENESIS AND TRAFFICKING
WNT LIGAND BIOGENESIS AND TRAFFICKING
metric value
setSize 21
pMANOVA 0.0047
p.adjustMANOVA 0.0246
s.dist 0.525
s.LPS 0.398
s.OVA 0.343
p.LPS 0.00161
p.OVA 0.00645



Top 20 genes
Gene LPS OVA
Wls 8022 8310
Wnt9b 7200 9223
Vps35 6665 8865
Wnt11 8278 6744
Vps26a 4643 8130
Wnt9a 3750 8473
Wnt3 3462 5885
Wnt2 2427 5760
Snx3 6973 1960
Wnt7b 4568 2290
Wnt2b 2446 3974
Wnt16 1054 4016
Vps29 4542 899
Porcn 765 4488
Wnt10a 2466 617
Wnt7a 2233 448
Tmed5 169 1728
Wnt5b 160 1741

Click HERE to show all gene set members

All member genes
LPS OVA
Porcn 765 4488
Snx3 6973 1960
Tmed5 169 1728
Vps26a 4643 8130
Vps29 4542 899
Vps35 6665 8865
Wls 8022 8310
Wnt10a 2466 617
Wnt11 8278 6744
Wnt16 1054 4016
Wnt2 2427 5760
Wnt2b 2446 3974
Wnt3 3462 5885
Wnt4 1500 -4215
Wnt5a -5605 -2251
Wnt5b 160 1741
Wnt6 -1583 -2355
Wnt7a 2233 448
Wnt7b 4568 2290
Wnt9a 3750 8473
Wnt9b 7200 9223



GLYCOGEN SYNTHESIS
GLYCOGEN SYNTHESIS
metric value
setSize 14
pMANOVA 0.0142
p.adjustMANOVA 0.0557
s.dist 0.522
s.LPS 0.449
s.OVA 0.266
p.LPS 0.00362
p.OVA 0.0849



Top 20 genes
Gene LPS OVA
Pgm1 8264 9024
Ugp2 8040 8940
Gbe1 7259 8707
Epm2a 5060 6793
Ubc 4470 5873
Gyg 7658 2369
Gys1 1864 7836
Ppp1r3c 2863 3247
Pgm2 6597 1173
Nhlrc1 6891 121

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All member genes
LPS OVA
Epm2a 5060 6793
Gbe1 7259 8707
Gyg 7658 2369
Gys1 1864 7836
Nhlrc1 6891 121
Pgm1 8264 9024
Pgm2 6597 1173
Pgm2l1 -2556 -1765
Ppp1r3c 2863 3247
Rps27a -474 -2054
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873
Ugp2 8040 8940



GLYCOGEN STORAGE DISEASES
GLYCOGEN STORAGE DISEASES
metric value
setSize 12
pMANOVA 0.0209
p.adjustMANOVA 0.0737
s.dist 0.507
s.LPS 0.454
s.OVA 0.225
p.LPS 0.00643
p.OVA 0.177



Top 20 genes
Gene LPS OVA
Gbe1 7259 8707
Epm2a 5060 6793
G6pc3 6400 4208
Ubc 4470 5873
Gaa 7485 3120
Gyg 7658 2369
Gys1 1864 7836
Ppp1r3c 2863 3247
Nhlrc1 6891 121

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All member genes
LPS OVA
Epm2a 5060 6793
G6pc3 6400 4208
Gaa 7485 3120
Gbe1 7259 8707
Gyg 7658 2369
Gys1 1864 7836
Nhlrc1 6891 121
Ppp1r3c 2863 3247
Rps27a -474 -2054
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873



CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
metric value
setSize 49
pMANOVA 1.08e-05
p.adjustMANOVA 0.000249
s.dist 0.506
s.LPS 0.37
s.OVA 0.346
p.LPS 7.32e-06
p.OVA 2.86e-05



Top 20 genes
Gene LPS OVA
Rp2 7315 9069
Exoc3 7715 8123
Arf4 7960 7361
Lztfl1 6460 8899
Mkks 7976 7175
Exoc7 6521 8235
Tcp1 6594 8066
Mchr1 7207 7350
Arl6 6928 7336
Cct3 7102 6549
Pde6d 7273 6095
Bbs10 7829 5568
Cct5 7278 5983
Rab3ip 6181 7022
Unc119b 5253 8034
Bbs1 5888 7036
Ttc8 6131 5690
Cct4 6209 5468
Bbs7 4486 6358
Cys1 6071 4245

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All member genes
LPS OVA
Arf4 7960 7361
Arl13b 2453 2790
Arl3 519 -2263
Arl6 6928 7336
Asap1 -601 21
Bbip1 1824 -684
Bbs1 5888 7036
Bbs10 7829 5568
Bbs12 -5743 -115
Bbs2 2148 307
Bbs4 1645 5488
Bbs5 -5658 -4835
Bbs7 4486 6358
Bbs9 7186 -196
Cct2 3805 3760
Cct3 7102 6549
Cct4 6209 5468
Cct5 7278 5983
Cct8 6442 3134
Cnga4 -225 -1801
Cngb1 -9081 -8022
Cys1 6071 4245
Exoc1 2795 4014
Exoc2 -2071 1203
Exoc3 7715 8123
Exoc4 6054 2455
Exoc5 -5531 8344
Exoc6 1637 86
Exoc7 6521 8235
Exoc8 2548 1067
Gbf1 3342 5698
Inpp5e -2185 44
Lztfl1 6460 8899
Mchr1 7207 7350
Mkks 7976 7175
Nphp3 -3916 -3643
Pde6d 7273 6095
Pkd1 -6218 -2852
Pkd2 -4408 -195
Rab11a -152 4126
Rab11fip3 1296 6175
Rab3ip 6181 7022
Rab8a 5770 2912
Rp2 7315 9069
Smo 5019 5076
Sstr3 -5330 3302
Tcp1 6594 8066
Ttc8 6131 5690
Unc119b 5253 8034



INSULIN PROCESSING
INSULIN PROCESSING
metric value
setSize 24
pMANOVA 0.00391
p.adjustMANOVA 0.0216
s.dist 0.504
s.LPS 0.347
s.OVA 0.366
p.LPS 0.00326
p.OVA 0.00193



Top 20 genes
Gene LPS OVA
Pcsk1 7855 8939
Exoc3 7715 8123
Ero1a 6686 8249
Exoc7 6521 8235
Pcsk2 6283 6728
Cpe 6474 6243
Myrip 3919 8690
Slc30a7 4401 6889
Slc30a5 3546 6791
Exoc4 6054 2455
Exoc1 2795 4014
Ero1b 2944 924
Exoc8 2548 1067
Exoc6 1637 86

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All member genes
LPS OVA
Cpe 6474 6243
Ero1a 6686 8249
Ero1b 2944 924
Exoc1 2795 4014
Exoc2 -2071 1203
Exoc3 7715 8123
Exoc4 6054 2455
Exoc5 -5531 8344
Exoc6 1637 86
Exoc7 6521 8235
Exoc8 2548 1067
Kif5a -395 5647
Kif5b -8074 -2095
Kif5c -5661 3806
Myo5a -79 5781
Myrip 3919 8690
Pcsk1 7855 8939
Pcsk2 6283 6728
Rab27a -2296 -33
Slc30a5 3546 6791
Slc30a6 5533 -370
Slc30a7 4401 6889
Stx1a 7220 -4214
Vamp2 4672 -5458



SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
metric value
setSize 11
pMANOVA 0.00216
p.adjustMANOVA 0.0146
s.dist 0.502
s.LPS 0.0586
s.OVA 0.499
p.LPS 0.737
p.OVA 0.00419



Top 20 genes
Gene LPS OVA
Fig4 6198 9162
Vac14 6537 5886
Pik3c3 3970 6884
Pik3r4 2142 6152
Mtmr4 323 4779
Mtmr7 171 5116

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All member genes
LPS OVA
Fig4 6198 9162
Mtm1 -572 5738
Mtmr2 -3345 6001
Mtmr4 323 4779
Mtmr7 171 5116
Mtmr9 -4431 -1094
Pik3c2a -2933 6799
Pik3c3 3970 6884
Pik3r4 2142 6152
Pikfyve -7002 -1352
Vac14 6537 5886



GLYCOGEN METABOLISM
GLYCOGEN METABOLISM
metric value
setSize 25
pMANOVA 0.00168
p.adjustMANOVA 0.0125
s.dist 0.499
s.LPS 0.413
s.OVA 0.28
p.LPS 0.000353
p.OVA 0.0152



Top 20 genes
Gene LPS OVA
Pgm1 8264 9024
Ugp2 8040 8940
Gbe1 7259 8707
Pygm 6818 9147
Pygb 7322 6290
Phkb 5256 8679
Epm2a 5060 6793
Ubc 4470 5873
Phka1 3645 7003
Gaa 7485 3120
Gyg 7658 2369
Gys1 1864 7836
Ppp1r3c 2863 3247
Pgm2 6597 1173
Agl 1024 5050
Phkg2 1343 1263
Phkg1 1365 1146
Nhlrc1 6891 121

Click HERE to show all gene set members

All member genes
LPS OVA
Agl 1024 5050
Calm1 448 -3050
Epm2a 5060 6793
Gaa 7485 3120
Gbe1 7259 8707
Gyg 7658 2369
Gys1 1864 7836
Nhlrc1 6891 121
Pgm1 8264 9024
Pgm2 6597 1173
Pgm2l1 -2556 -1765
Phka1 3645 7003
Phka2 -1531 283
Phkb 5256 8679
Phkg1 1365 1146
Phkg2 1343 1263
Ppp1r3c 2863 3247
Pygb 7322 6290
Pygl -2581 -4088
Pygm 6818 9147
Rps27a -474 -2054
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873
Ugp2 8040 8940



FATTY ACYL COA BIOSYNTHESIS
FATTY ACYL COA BIOSYNTHESIS
metric value
setSize 32
pMANOVA 0.000725
p.adjustMANOVA 0.00685
s.dist 0.499
s.LPS 0.343
s.OVA 0.362
p.LPS 0.000779
p.OVA 4e-04



Top 20 genes
Gene LPS OVA
Ppt1 7985 9079
Acsbg1 7586 9139
Hsd17b12 7581 7845
Rpp14 6559 8924
Acsl4 7696 7303
Acsl6 6010 8414
Elovl1 7423 6274
Hacd2 6471 7159
Elovl4 5813 6543
Acsl3 4248 8897
Scd2 5986 4888
Scd1 5495 4645
Elovl2 2599 8770
Acsl1 2701 7510
Acsl5 4883 3724
Elovl5 2618 6090
Fasn 3300 4733
Elovl6 2846 3667
Hacd3 5844 1133
Acly 1342 4761

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All member genes
LPS OVA
Acaca -3289 3624
Acly 1342 4761
Acsbg1 7586 9139
Acsf3 -1804 4009
Acsl1 2701 7510
Acsl3 4248 8897
Acsl4 7696 7303
Acsl5 4883 3724
Acsl6 6010 8414
Cbr4 -3149 6050
Elovl1 7423 6274
Elovl2 2599 8770
Elovl4 5813 6543
Elovl5 2618 6090
Elovl6 2846 3667
Elovl7 -8038 -5826
Fasn 3300 4733
H2-Ke6 -4703 -6587
Hacd1 -8674 -5353
Hacd2 6471 7159
Hacd3 5844 1133
Hacd4 -3844 6672
Hsd17b12 7581 7845
Morc2a -6254 -4905
Ppt1 7985 9079
Ppt2 1957 -1264
Rpp14 6559 8924
Scd1 5495 4645
Scd2 5986 4888
Slc25a1 6238 -647
Slc27a3 2106 -2373
Tecr 6970 -4007



COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
metric value
setSize 26
pMANOVA 1.99e-05
p.adjustMANOVA 0.000397
s.dist 0.498
s.LPS 0.477
s.OVA 0.142
p.LPS 2.52e-05
p.OVA 0.211



Top 20 genes
Gene LPS OVA
Cct6a 8085 8933
Tubb2b 7454 8823
Tcp1 6594 8066
Cct3 7102 6549
Cct5 7278 5983
Tubb2a 8077 4594
Tuba1b 7821 4725
Cct4 6209 5468
Tuba4a 7160 3678
Tubb4a 7467 3033
Cct8 6442 3134
Cct7 4810 3668
Tubb4b 7572 2013
Cct2 3805 3760
Tuba1a 7019 1823
Pfdn4 4499 2404
Vbp1 3157 1446

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All member genes
LPS OVA
Actb -8328 -7800
Cct2 3805 3760
Cct3 7102 6549
Cct4 6209 5468
Cct5 7278 5983
Cct6a 8085 8933
Cct7 4810 3668
Cct8 6442 3134
Pfdn1 570 -697
Pfdn2 -4880 -5684
Pfdn4 4499 2404
Pfdn5 -3171 -2137
Pfdn6 -3779 -4623
Tcp1 6594 8066
Tuba1a 7019 1823
Tuba1b 7821 4725
Tuba1c 4455 -1804
Tuba4a 7160 3678
Tuba8 -5538 -1625
Tubb2a 8077 4594
Tubb2b 7454 8823
Tubb3 5805 -2350
Tubb4a 7467 3033
Tubb4b 7572 2013
Tubb6 1795 -4655
Vbp1 3157 1446



KERATAN SULFATE KERATIN METABOLISM
KERATAN SULFATE KERATIN METABOLISM
metric value
setSize 30
pMANOVA 3.72e-05
p.adjustMANOVA 0.000664
s.dist 0.498
s.LPS 0.457
s.OVA 0.197
p.LPS 1.46e-05
p.OVA 0.062



Top 20 genes
Gene LPS OVA
B4galt4 8080 9233
B4gat1 7815 6655
Chst2 6862 7316
B3gnt2 6412 7769
St3gal4 5376 8530
Prelp 8253 3938
Gns 4624 6216
B4galt2 7005 4082
St3gal2 4771 5947
Hexb 4272 4685
Chst1 5696 3434
Fmod 3990 4068
St3gal3 1860 8282
Chst5 1476 3786
B4galt3 2017 2092
Slc35d2 3247 880
Glb1 2188 1249
Glb1l 548 4440
B4galt5 1625 1347
B3gnt7 2805 562

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All member genes
LPS OVA
Acan 5225 -1263
B3gnt2 6412 7769
B3gnt4 4143 -2702
B3gnt7 2805 562
B4galt1 7158 -2643
B4galt2 7005 4082
B4galt3 2017 2092
B4galt4 8080 9233
B4galt5 1625 1347
B4galt6 4153 -2755
B4gat1 7815 6655
Chst1 5696 3434
Chst2 6862 7316
Chst5 1476 3786
Fmod 3990 4068
Galns -4049 -3362
Glb1 2188 1249
Glb1l 548 4440
Gns 4624 6216
Hexa 5596 -480
Hexb 4272 4685
Lum 3365 -3697
Ogn -1917 -1341
Prelp 8253 3938
Slc35d2 3247 880
St3gal1 2411 -236
St3gal2 4771 5947
St3gal3 1860 8282
St3gal4 5376 8530
St3gal6 -7804 -7656



SPHINGOLIPID METABOLISM
SPHINGOLIPID METABOLISM
metric value
setSize 80
pMANOVA 6.26e-09
p.adjustMANOVA 4.09e-07
s.dist 0.495
s.LPS 0.301
s.OVA 0.393
p.LPS 3.31e-06
p.OVA 1.21e-09



Top 20 genes
Gene LPS OVA
B3galnt1 7997 9137
Sptlc1 7605 8759
Galc 7162 8790
Arsa 6692 8889
Ormdl1 6337 9141
Degs2 7869 7285
B4galnt1 7700 7388
Asah1 6583 8559
Arsb 6679 8194
Esyt1 6539 8359
Gba2 6741 7374
Fa2h 6120 8042
Neu4 5715 8437
Prkd1 6932 6952
Ugt8a 7398 6299
Degs1 5710 7862
Gla 4878 9109
Plpp1 6449 6765
Ormdl2 5149 7848
Gltp 6270 5960

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All member genes
LPS OVA
Acer2 -9048 -1939
Acer3 -3492 -3226
Aldh3a2 -2392 6594
Aldh3b1 -1321 -2876
Arsa 6692 8889
Arsb 6679 8194
Arsg -3285 3766
Arsj -2289 -3267
Arsk 1758 2988
Asah1 6583 8559
Asah2 -2407 -753
B3galnt1 7997 9137
B4galnt1 7700 7388
Cerk -4511 5187
Cers1 2341 5818
Cers2 4863 3093
Cers4 -6513 -6971
Cers5 -2156 5883
Cers6 5642 4360
Cert1 -2946 5961
Cptp -911 5040
Csnk1g2 2076 5676
Ctsa -2113 -3047
Degs1 5710 7862
Degs2 7869 7285
Esyt1 6539 8359
Esyt2 -6817 800
Esyt3 -117 -7279
Fa2h 6120 8042
Galc 7162 8790
Gba 5519 3987
Gba2 6741 7374
Gla 4878 9109
Glb1 2188 1249
Glb1l 548 4440
Gltp 6270 5960
Gm2a 6046 4990
Hexa 5596 -480
Hexb 4272 4685
Kdsr -2045 -2788
Neu1 6664 5371
Neu2 6964 5099
Neu3 2468 8852
Neu4 5715 8437
Ormdl1 6337 9141
Ormdl2 5149 7848
Ormdl3 3622 4927
Osbp 442 7029
Plpp1 6449 6765
Plpp2 3227 1340
Plpp3 2827 7864
Ppm1l -4942 3761
Prkd1 6932 6952
Prkd2 -58 2899
Prkd3 -1887 6250
Psap 5604 6262
Samd8 -8925 -5743
Sgms1 -3030 7773
Sgms2 4147 5964
Sgpl1 -2915 5083
Sgpp1 3053 5719
Sgpp2 3114 5530
Smpd1 6830 2471
Smpd2 -2796 -411
Smpd3 4172 2160
Smpd4 -2112 -3327
Sphk1 4714 4745
Sphk2 1738 -2004
Spns2 824 2446
Sptlc1 7605 8759
Sptlc2 -7171 4608
Sptlc3 6252 4163
Sptssa 4221 7189
Sptssb 2122 3124
Sumf1 2198 672
Sumf2 2163 -146
Ugcg 2950 6252
Ugt8a 7398 6299
Vapa 3051 -2517
Vapb 5545 4022



CD28 DEPENDENT VAV1 PATHWAY
CD28 DEPENDENT VAV1 PATHWAY
metric value
setSize 11
pMANOVA 0.0558
p.adjustMANOVA 0.15
s.dist 0.491
s.LPS 0.418
s.OVA 0.257
p.LPS 0.0164
p.OVA 0.14



Top 20 genes
Gene LPS OVA
Rac1 5983 8506
Pak2 5856 8623
Pak1 6329 7338
Fyn 4378 8562
Cdc42 3616 4272
Vav1 1289 6484
Lck 3266 1842
Cd86 6391 361

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All member genes
LPS OVA
Cd80 -4654 -7619
Cd86 6391 361
Cdc42 3616 4272
Fyn 4378 8562
Grb2 -446 -1869
Lck 3266 1842
Pak1 6329 7338
Pak2 5856 8623
Pak3 3560 -5648
Rac1 5983 8506
Vav1 1289 6484



IRE1ALPHA ACTIVATES CHAPERONES
IRE1ALPHA ACTIVATES CHAPERONES
metric value
setSize 50
pMANOVA 1.13e-05
p.adjustMANOVA 0.000257
s.dist 0.489
s.LPS 0.384
s.OVA 0.304
p.LPS 2.69e-06
p.OVA 0.000204



Top 20 genes
Gene LPS OVA
Hspa5 8251 9072
Xbp1 8203 8916
Dnajc3 8287 8715
Pdia6 8295 8674
Atp6v0d1 7539 8656
Tpp1 8306 7675
Gfpt1 7007 7359
Srpr 6243 8113
Cxxc1 5147 8766
Syvn1 5132 7943
Ppp2r5b 5720 6652
Dnajb11 7502 4825
Dnajb9 7003 5125
Serp1 4315 8196
Srprb 7639 4330
Fkbp14 3725 8877
Dctn1 6147 4919
Hyou1 6116 4939
Ssr1 5227 4055
Gsk3a 4721 4023

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All member genes
LPS OVA
Acadvl -5435 -3862
Add1 4786 3836
Arfgap1 -626 -6799
Atp6v0d1 7539 8656
Ctdsp2 -495 5795
Cul7 -174 -7169
Cxxc1 5147 8766
Dctn1 6147 4919
Ddx11 -7 2099
Dnajb11 7502 4825
Dnajb9 7003 5125
Dnajc3 8287 8715
Edem1 -1052 5340
Ern1 -1066 5815
Extl1 -3792 -874
Extl2 1786 4007
Extl3 128 3898
Fkbp14 3725 8877
Gfpt1 7007 7359
Gosr2 4948 3107
Gsk3a 4721 4023
Hdgf 2593 -1682
Hspa5 8251 9072
Hyou1 6116 4939
Kdelr3 6036 -5759
Klhdc3 3572 364
Lmna 6233 1615
Mydgf -421 -2902
Pdia5 -6695 -3145
Pdia6 8295 8674
Pla2g4b 347 -2450
Ppp2r5b 5720 6652
Preb 6130 -1319
Sec31a 2648 6291
Serp1 4315 8196
Shc1 1313 1270
Srpr 6243 8113
Srprb 7639 4330
Ssr1 5227 4055
Sult1a1 -436 9055
Syvn1 5132 7943
Tatdn2 -2640 3887
Tln1 564 2135
Tpp1 8306 7675
Tspyl2 -19 -786
Wfs1 -2849 -447
Wipi1 -6530 -5543
Xbp1 8203 8916
Yif1a 5579 2631
Zbtb17 1425 2102



CTLA4 INHIBITORY SIGNALING
CTLA4 INHIBITORY SIGNALING
metric value
setSize 20
pMANOVA 0.0116
p.adjustMANOVA 0.048
s.dist 0.487
s.LPS 0.31
s.OVA 0.376
p.LPS 0.0165
p.OVA 0.00358



Top 20 genes
Gene LPS OVA
Ppp2r5d 8125 7956
Ppp2r5c 5695 7367
Ppp2r5b 5720 6652
Fyn 4378 8562
Ptpn11 3741 9203
Ppp2r5e 4529 7330
Ppp2ca 6292 5124
Ppp2r1a 5551 4599
Akt1 2861 6592
Yes1 1963 8566
Src 2537 5624
Lck 3266 1842
Cd86 6391 361
Ppp2r5a 1268 969

Click HERE to show all gene set members

All member genes
LPS OVA
Akt1 2861 6592
Akt2 -861 -504
Akt3 -548 4221
Cd80 -4654 -7619
Cd86 6391 361
Fyn 4378 8562
Lck 3266 1842
Lyn -5272 -2052
Ppp2ca 6292 5124
Ppp2cb -500 -1856
Ppp2r1a 5551 4599
Ppp2r1b -4729 3965
Ppp2r5a 1268 969
Ppp2r5b 5720 6652
Ppp2r5c 5695 7367
Ppp2r5d 8125 7956
Ppp2r5e 4529 7330
Ptpn11 3741 9203
Src 2537 5624
Yes1 1963 8566



SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
metric value
setSize 15
pMANOVA 0.0278
p.adjustMANOVA 0.0923
s.dist 0.487
s.LPS 0.281
s.OVA 0.398
p.LPS 0.0597
p.OVA 0.00759



Top 20 genes
Gene LPS OVA
Fig4 6198 9162
Sacm1l 5905 7665
Pi4k2a 5773 7198
Vac14 6537 5886
Arf1 6829 4835
Pik3c3 3970 6884
Pi4kb 4892 5128
Ocrl 2494 6041
Pik3r4 2142 6152

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All member genes
LPS OVA
Arf1 6829 4835
Arf3 1373 -1714
Fig4 6198 9162
Inpp5e -2185 44
Ocrl 2494 6041
Pi4k2a 5773 7198
Pi4k2b -2587 -2241
Pi4ka -869 74
Pi4kb 4892 5128
Pik3c2a -2933 6799
Pik3c3 3970 6884
Pik3r4 2142 6152
Pikfyve -7002 -1352
Sacm1l 5905 7665
Vac14 6537 5886



SCAVENGING OF HEME FROM PLASMA
SCAVENGING OF HEME FROM PLASMA
metric value
setSize 11
pMANOVA 0.0479
p.adjustMANOVA 0.135
s.dist 0.485
s.LPS -0.234
s.OVA -0.425
p.LPS 0.179
p.OVA 0.0146



Top 20 genes
Gene LPS OVA
Apol7e -7417 -6847
Apol9a -7629 -6582
Jchain -8578 -4985
Hbb-bt -3702 -5455
Hp -391 -6716

Click HERE to show all gene set members

All member genes
LPS OVA
Apoa1 1484 -2813
Apol7e -7417 -6847
Apol8 -1738 1397
Apol9a -7629 -6582
Cd163 -4838 4551
Hba-a1 2101 -5302
Hba-a2 3885 -4209
Hbb-bt -3702 -5455
Hp -391 -6716
Jchain -8578 -4985
Lrp1 -206 2271



WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
metric value
setSize 13
pMANOVA 0.0343
p.adjustMANOVA 0.109
s.dist 0.482
s.LPS 0.415
s.OVA 0.246
p.LPS 0.00962
p.OVA 0.125



Top 20 genes
Gene LPS OVA
Fzd2 8149 7727
Fzd5 6640 8536
Ap2b1 7472 7369
Ap2a2 6936 7060
Ap2m1 7740 4087
Cltc 4453 6225
Ap2a1 6070 3853

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All member genes
LPS OVA
Ap2a1 6070 3853
Ap2a2 6936 7060
Ap2b1 7472 7369
Ap2m1 7740 4087
Ap2s1 -3449 -4270
Clta 3533 -54
Cltb 3105 -3410
Cltc 4453 6225
Fzd2 8149 7727
Fzd5 6640 8536
Ror1 -6515 4470
Ror2 3148 -4165
Wnt5a -5605 -2251



MET ACTIVATES RAP1 AND RAC1
MET ACTIVATES RAP1 AND RAC1
metric value
setSize 10
pMANOVA 0.0286
p.adjustMANOVA 0.094
s.dist 0.48
s.LPS 0.159
s.OVA 0.453
p.LPS 0.383
p.OVA 0.0132



Top 20 genes
Gene LPS OVA
Rap1b 7961 7714
Rac1 5983 8506
Crkl 5083 7322
Rap1a 1813 5101
Crk 982 6721
Met 1173 3904

Click HERE to show all gene set members

All member genes
LPS OVA
Crk 982 6721
Crkl 5083 7322
Dock7 -7552 -1952
Gab1 -3651 5952
Grb2 -446 -1869
Met 1173 3904
Rac1 5983 8506
Rap1a 1813 5101
Rap1b 7961 7714
Rapgef1 -1579 3757



INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
metric value
setSize 22
pMANOVA 0.00425
p.adjustMANOVA 0.023
s.dist 0.48
s.LPS 0.407
s.OVA 0.254
p.LPS 0.000957
p.OVA 0.0392



Top 20 genes
Gene LPS OVA
Prnp 7123 8627
Get3 7085 6986
Bag6 5862 7681
App 5561 7605
Serp1 4315 8196
Cyb5a 5048 6103
Emd 4423 6442
Ubl4a 5345 5249
Get1 8023 1983
Hmox1 1070 8479
Sec61g 2191 1297
Caml 498 3899
Stx5a 584 2291

Click HERE to show all gene set members

All member genes
LPS OVA
Aldh3a2 -2392 6594
App 5561 7605
Bag6 5862 7681
Caml 498 3899
Cyb5a 5048 6103
Emd 4423 6442
Get1 8023 1983
Get3 7085 6986
Get4 -938 -2098
Hmox1 1070 8479
Otof -907 -2228
Prnp 7123 8627
Sec61b -1199 -303
Sec61g 2191 1297
Serp1 4315 8196
Sgta 5103 -2916
Stx1a 7220 -4214
Stx5a 584 2291
Ube2j2 -2781 -578
Ubl4a 5345 5249
Vamp2 4672 -5458
Vapa 3051 -2517



ADENYLATE CYCLASE INHIBITORY PATHWAY
ADENYLATE CYCLASE INHIBITORY PATHWAY
metric value
setSize 13
pMANOVA 0.0589
p.adjustMANOVA 0.155
s.dist 0.479
s.LPS 0.3
s.OVA 0.374
p.LPS 0.0611
p.OVA 0.0196



Top 20 genes
Gene LPS OVA
Gnai3 5867 6755
Gnai2 5682 6854
Gnai1 4826 8037
Adcy3 5377 5540
Gnal 4210 3997
Adcy5 3009 5016
Adcy2 4407 3012
Adcy7 2324 1708

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 -7161 3272
Adcy2 4407 3012
Adcy3 5377 5540
Adcy4 6693 -1186
Adcy5 3009 5016
Adcy6 -1993 -2471
Adcy7 2324 1708
Adcy8 -444 7306
Adcy9 -4139 1908
Gnai1 4826 8037
Gnai2 5682 6854
Gnai3 5867 6755
Gnal 4210 3997



SUPPRESSION OF PHAGOSOMAL MATURATION
SUPPRESSION OF PHAGOSOMAL MATURATION
metric value
setSize 12
pMANOVA 0.0614
p.adjustMANOVA 0.16
s.dist 0.478
s.LPS 0.393
s.OVA 0.271
p.LPS 0.0183
p.OVA 0.104



Top 20 genes
Gene LPS OVA
Rab5a 7155 8793
Atp6v1h 6911 7530
Hgs 5304 5802
Ubc 4470 5873
Kpna1 5112 4529
Vps33b 2919 7702
Kpnb1 3077 5561
Rab7 5457 1268
Coro1a 3168 45

Click HERE to show all gene set members

All member genes
LPS OVA
Atp6v1h 6911 7530
Coro1a 3168 45
Hgs 5304 5802
Kpna1 5112 4529
Kpnb1 3077 5561
Rab5a 7155 8793
Rab7 5457 1268
Rps27a -474 -2054
Uba52 -8154 -7791
Ubb 1292 -2097
Ubc 4470 5873
Vps33b 2919 7702



HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
metric value
setSize 48
pMANOVA 5.14e-10
p.adjustMANOVA 5.04e-08
s.dist 0.473
s.LPS 0.465
s.OVA 0.0873
p.LPS 2.44e-08
p.OVA 0.295



Top 20 genes
Gene LPS OVA
Tubb2b 7454 8823
Capza2 7653 8008
Hspa2 8226 7167
Dctn4 7129 8231
Fkbp5 5947 8602
Hspa1b 8108 5705
Dnaja2 7931 5636
Dctn6 6421 6163
Tubb2a 8077 4594
Tuba1b 7821 4725
Actr1a 7339 4722
Dync1i1 5722 5693
Dctn1 6147 4919
Capza1 7205 4155
Dnaja1 7277 3995
Tuba4a 7160 3678
Tubb4a 7467 3033
Nr3c2 2388 6676
Actr10 2946 5268
Tubb4b 7572 2013

Click HERE to show all gene set members

All member genes
LPS OVA
Actr10 2946 5268
Actr1a 7339 4722
Ar 265 -5182
Capza1 7205 4155
Capza2 7653 8008
Capzb 5172 2826
Dctn1 6147 4919
Dctn2 3294 2496
Dctn3 327 -3092
Dctn4 7129 8231
Dctn5 5397 -1095
Dctn6 6421 6163
Dnaja1 7277 3995
Dnaja2 7931 5636
Dnaja4 7506 -1428
Dnajb1 1782 -1079
Dync1h1 1330 2841
Dync1i1 5722 5693
Dync1i2 -3871 -3711
Dync1li1 2609 -771
Dync1li2 -3515 711
Dynll1 3588 -3373
Dynll2 -1874 -1448
Fkbp4 5575 -1911
Fkbp5 5947 8602
Hsp90aa1 -2947 -7320
Hsp90ab1 -2328 -3991
Hspa1a -5055 -7006
Hspa1b 8108 5705
Hspa1l -2897 -4114
Hspa2 8226 7167
Hspa8 4970 1014
Nr3c1 -1002 2198
Nr3c2 2388 6676
Pgr -3512 -1619
Ptges3 3527 -5133
Stip1 6784 479
Tuba1a 7019 1823
Tuba1b 7821 4725
Tuba1c 4455 -1804
Tuba4a 7160 3678
Tuba8 -5538 -1625
Tubb2a 8077 4594
Tubb2b 7454 8823
Tubb3 5805 -2350
Tubb4a 7467 3033
Tubb4b 7572 2013
Tubb6 1795 -4655



POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
metric value
setSize 26
pMANOVA 0.0014
p.adjustMANOVA 0.0112
s.dist 0.473
s.LPS 0.238
s.OVA 0.409
p.LPS 0.0357
p.OVA 0.000306



Top 20 genes
Gene LPS OVA
Nup54 7762 8787
Ndc1 8208 8094
Rcc1 6043 7423
Tnpo1 4905 7000
Sec13 5617 5634
Nup37 5298 5640
Nup107 4390 6284
Ube2i 5454 4354
Pom121 4112 5763
Kpnb1 3077 5561
Ran 4886 2845
Sumo1 4748 2892
Rangap1 4497 2262
Nup205 627 6119
Nup85 793 4474
Ahctf1 404 4448
Nup35 391 1602

Click HERE to show all gene set members

All member genes
LPS OVA
Ahctf1 404 4448
Kpnb1 3077 5561
Ndc1 8208 8094
Nup107 4390 6284
Nup133 -3912 5678
Nup155 -5221 -2893
Nup160 -997 7310
Nup188 -459 3183
Nup205 627 6119
Nup35 391 1602
Nup37 5298 5640
Nup43 -1843 1242
Nup54 7762 8787
Nup62 -1432 -1889
Nup85 793 4474
Nup93 -6229 -1271
Nup98 -2866 2172
Pom121 4112 5763
Ran 4886 2845
Rangap1 4497 2262
Rcc1 6043 7423
Sec13 5617 5634
Seh1l -5056 4675
Sumo1 4748 2892
Tnpo1 4905 7000
Ube2i 5454 4354



SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
metric value
setSize 16
pMANOVA 0.000142
p.adjustMANOVA 0.00189
s.dist 0.47
s.LPS 0.0141
s.OVA 0.47
p.LPS 0.922
p.OVA 0.00113



Top 20 genes
Gene LPS OVA
Fig4 6198 9162
Pi4k2a 5773 7198
Vac14 6537 5886
Pik3c3 3970 6884
Inpp5f 3448 7542
Pik3r4 2142 6152
Mtmr4 323 4779

Click HERE to show all gene set members

All member genes
LPS OVA
Fig4 6198 9162
Inpp4a -6209 -4751
Inpp4b -820 5607
Inpp5f 3448 7542
Mtm1 -572 5738
Mtmr10 -6489 8818
Mtmr12 -3107 2410
Mtmr2 -3345 6001
Mtmr4 323 4779
Pi4k2a 5773 7198
Pi4k2b -2587 -2241
Pik3c2a -2933 6799
Pik3c3 3970 6884
Pik3r4 2142 6152
Pikfyve -7002 -1352
Vac14 6537 5886



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report