date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik 0.4565576
0610009E02Rik -0.4069908
0610009L18Rik -0.1869110
0610010K14Rik -0.3711485
0610012G03Rik -0.3421633
0610030E20Rik 0.0842539

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17643
duplicated_genes_present 0
num_profile_genes_in_sets 8424
num_profile_genes_not_in_sets 9219

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 426
num_genesets_included 1178

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
CITRIC ACID CYCLE TCA CYCLE 22 4.62e-05 0.502 1.21e-03
OLFACTORY SIGNALING PATHWAY 37 1.49e-07 -0.499 1.10e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 4.20e-03 0.499 3.29e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.04e-03 0.494 2.58e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.61e-03 0.485 2.96e-02
CALNEXIN CALRETICULIN CYCLE 26 2.34e-05 0.479 7.88e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.58e-04 0.476 2.98e-03
RHOBTB3 ATPASE CYCLE 10 9.35e-03 0.475 5.84e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 1.92e-04 0.470 3.37e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.14e-03 0.470 1.27e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.98e-03 0.461 3.17e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 1.24e-02 0.456 7.12e-02
MET ACTIVATES RAP1 AND RAC1 10 1.32e-02 0.452 7.32e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.74e-04 0.452 3.20e-03
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.81e-03 0.435 3.63e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.87e-02 0.429 8.99e-02
SCAVENGING OF HEME FROM PLASMA 11 1.44e-02 -0.426 7.58e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.82e-04 0.426 1.14e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.56e-05 0.422 5.97e-04
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 1.88e-04 0.415 3.35e-03
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.11e-04 0.409 4.58e-03
CARNITINE METABOLISM 14 8.33e-03 0.407 5.32e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 2.59e-02 0.407 1.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 2.59e-02 0.407 1.11e-01
PROLONGED ERK ACTIVATION EVENTS 14 9.37e-03 0.401 5.84e-02
FERTILIZATION 13 1.29e-02 -0.398 7.24e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.62e-03 0.398 5.04e-02
GLYCOSPHINGOLIPID METABOLISM 38 2.62e-05 0.394 8.13e-04
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 3.82e-03 0.394 3.06e-02
SPHINGOLIPID METABOLISM 80 1.26e-09 0.393 1.86e-07
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 2.42e-02 -0.393 1.07e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 1.24e-05 0.390 5.17e-04
NUCLEOBASE BIOSYNTHESIS 15 1.00e-02 0.384 6.09e-02
COHESIN LOADING ONTO CHROMATIN 10 3.73e-02 0.380 1.43e-01
CTLA4 INHIBITORY SIGNALING 20 3.61e-03 0.376 2.96e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 1.97e-02 0.373 9.42e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.23e-02 0.373 7.09e-02
RHOV GTPASE CYCLE 33 2.40e-04 0.369 3.88e-03
PLATELET SENSITIZATION BY LDL 15 1.38e-02 0.367 7.44e-02
INSULIN PROCESSING 24 1.96e-03 0.365 1.87e-02
LDL CLEARANCE 16 1.15e-02 0.365 6.71e-02
FATTY ACYL COA BIOSYNTHESIS 32 4.06e-04 0.361 5.69e-03
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 4.92e-02 0.359 1.72e-01
RECEPTOR MEDIATED MITOPHAGY 11 4.05e-02 0.357 1.52e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.70e-02 0.356 8.57e-02
INTRA GOLGI TRAFFIC 43 6.25e-05 0.353 1.44e-03
RHOF GTPASE CYCLE 41 9.70e-05 0.352 2.04e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 2.38e-02 0.349 1.07e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 3.00e-02 0.348 1.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.92e-05 0.345 8.58e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
CITRIC ACID CYCLE TCA CYCLE 22 4.62e-05 0.502000 1.21e-03
OLFACTORY SIGNALING PATHWAY 37 1.49e-07 -0.499000 1.10e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 4.20e-03 0.499000 3.29e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.04e-03 0.494000 2.58e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.61e-03 0.485000 2.96e-02
CALNEXIN CALRETICULIN CYCLE 26 2.34e-05 0.479000 7.88e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.58e-04 0.476000 2.98e-03
RHOBTB3 ATPASE CYCLE 10 9.35e-03 0.475000 5.84e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 1.92e-04 0.470000 3.37e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.14e-03 0.470000 1.27e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.98e-03 0.461000 3.17e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 1.24e-02 0.456000 7.12e-02
MET ACTIVATES RAP1 AND RAC1 10 1.32e-02 0.452000 7.32e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.74e-04 0.452000 3.20e-03
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.81e-03 0.435000 3.63e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.87e-02 0.429000 8.99e-02
SCAVENGING OF HEME FROM PLASMA 11 1.44e-02 -0.426000 7.58e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.82e-04 0.426000 1.14e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.56e-05 0.422000 5.97e-04
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 1.88e-04 0.415000 3.35e-03
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.11e-04 0.409000 4.58e-03
CARNITINE METABOLISM 14 8.33e-03 0.407000 5.32e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 2.59e-02 0.407000 1.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 2.59e-02 0.407000 1.11e-01
PROLONGED ERK ACTIVATION EVENTS 14 9.37e-03 0.401000 5.84e-02
FERTILIZATION 13 1.29e-02 -0.398000 7.24e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.62e-03 0.398000 5.04e-02
GLYCOSPHINGOLIPID METABOLISM 38 2.62e-05 0.394000 8.13e-04
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 3.82e-03 0.394000 3.06e-02
SPHINGOLIPID METABOLISM 80 1.26e-09 0.393000 1.86e-07
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 2.42e-02 -0.393000 1.07e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 1.24e-05 0.390000 5.17e-04
NUCLEOBASE BIOSYNTHESIS 15 1.00e-02 0.384000 6.09e-02
COHESIN LOADING ONTO CHROMATIN 10 3.73e-02 0.380000 1.43e-01
CTLA4 INHIBITORY SIGNALING 20 3.61e-03 0.376000 2.96e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 1.97e-02 0.373000 9.42e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.23e-02 0.373000 7.09e-02
RHOV GTPASE CYCLE 33 2.40e-04 0.369000 3.88e-03
PLATELET SENSITIZATION BY LDL 15 1.38e-02 0.367000 7.44e-02
INSULIN PROCESSING 24 1.96e-03 0.365000 1.87e-02
LDL CLEARANCE 16 1.15e-02 0.365000 6.71e-02
FATTY ACYL COA BIOSYNTHESIS 32 4.06e-04 0.361000 5.69e-03
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 4.92e-02 0.359000 1.72e-01
RECEPTOR MEDIATED MITOPHAGY 11 4.05e-02 0.357000 1.52e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.70e-02 0.356000 8.57e-02
INTRA GOLGI TRAFFIC 43 6.25e-05 0.353000 1.44e-03
RHOF GTPASE CYCLE 41 9.70e-05 0.352000 2.04e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 2.38e-02 0.349000 1.07e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 3.00e-02 0.348000 1.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.92e-05 0.345000 8.58e-04
ACYL CHAIN REMODELLING OF PG 10 5.96e-02 0.344000 1.94e-01
RHOU GTPASE CYCLE 34 5.33e-04 0.343000 7.13e-03
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 6.54e-03 0.343000 4.54e-02
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 10 6.06e-02 -0.343000 1.94e-01
RAP1 SIGNALLING 15 2.27e-02 0.340000 1.04e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.72e-05 0.340000 8.22e-04
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.22e-02 0.339000 1.56e-01
CA DEPENDENT EVENTS 36 4.50e-04 0.338000 6.23e-03
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 15 2.42e-02 0.336000 1.07e-01
G PROTEIN MEDIATED EVENTS 52 3.02e-05 0.334000 8.58e-04
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 1.48e-02 0.332000 7.70e-02
DNA METHYLATION 23 5.98e-03 -0.331000 4.25e-02
NCAM1 INTERACTIONS 42 2.18e-04 -0.330000 3.57e-03
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 2.79e-02 0.328000 1.16e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.87e-02 0.326000 1.19e-01
PEROXISOMAL LIPID METABOLISM 27 3.48e-03 0.325000 2.89e-02
GLUTAMATE AND GLUTAMINE METABOLISM 13 4.26e-02 0.325000 1.56e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 3.04e-02 0.323000 1.23e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 53 5.33e-05 -0.321000 1.34e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.58e-02 0.320000 7.98e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 5.66e-03 0.320000 4.06e-02
SIGNALING BY HIPPO 20 1.39e-02 0.318000 7.44e-02
ACTIVATION OF SMO 16 2.84e-02 0.316000 1.18e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.22e-02 0.313000 2.17e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.83e-02 0.313000 8.87e-02
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 24 8.33e-03 -0.311000 5.32e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 5.32e-03 0.310000 3.92e-02
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 2.11e-04 0.309000 3.50e-03
RAF ACTIVATION 34 1.85e-03 0.309000 1.81e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 1.05e-02 -0.308000 6.27e-02
BIOTIN TRANSPORT AND METABOLISM 11 7.68e-02 0.308000 2.23e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 1.89e-03 -0.308000 1.84e-02
IRE1ALPHA ACTIVATES CHAPERONES 50 2.09e-04 0.303000 3.50e-03
EPHRIN SIGNALING 19 2.25e-02 0.302000 1.03e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 3.96e-07 -0.301000 2.46e-05
ERKS ARE INACTIVATED 13 6.07e-02 0.301000 1.94e-01
CONDENSATION OF PROPHASE CHROMOSOMES 30 4.40e-03 -0.300000 3.41e-02
O LINKED GLYCOSYLATION OF MUCINS 41 9.25e-04 0.299000 1.09e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 5.37e-02 0.298000 1.82e-01
INOSITOL PHOSPHATE METABOLISM 46 5.01e-04 0.297000 6.78e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 6.44e-02 0.296000 2.01e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 3.80e-03 0.296000 3.06e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 7.73e-02 0.295000 2.24e-01
COLLAGEN CHAIN TRIMERIZATION 41 1.11e-03 -0.294000 1.25e-02
EUKARYOTIC TRANSLATION ELONGATION 87 2.09e-06 -0.294000 1.17e-04
NEGATIVE REGULATION OF MET ACTIVITY 20 2.37e-02 0.292000 1.07e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 2.05e-02 0.292000 9.74e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 4.39e-02 -0.291000 1.60e-01
CD28 CO STIMULATION 31 5.19e-03 0.290000 3.84e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 6.04e-02 0.290000 1.94e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 7.04e-02 0.290000 2.15e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 1.09e-02 0.289000 6.41e-02
BETA CATENIN PHOSPHORYLATION CASCADE 16 4.69e-02 0.287000 1.67e-01
DAG AND IP3 SIGNALING 40 1.71e-03 0.287000 1.74e-02
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 5.50e-02 -0.286000 1.85e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 1.05e-01 -0.283000 2.74e-01
RHOB GTPASE CYCLE 69 5.01e-05 0.282000 1.28e-03
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 1.23e-01 0.282000 3.06e-01
PI METABOLISM 79 1.57e-05 0.281000 5.97e-04
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 2.58e-02 0.281000 1.11e-01
GLYCOGEN METABOLISM 25 1.54e-02 0.280000 7.88e-02
SYNTHESIS OF PA 29 9.08e-03 0.280000 5.72e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.34e-03 0.279000 1.42e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 4.03e-02 0.279000 1.51e-01
COMPLEX I BIOGENESIS 56 3.09e-04 -0.279000 4.58e-03
PARASITE INFECTION 54 4.03e-04 0.278000 5.69e-03
REGULATION OF IFNG SIGNALING 13 8.39e-02 0.277000 2.35e-01
RHOG GTPASE CYCLE 74 3.84e-05 0.277000 1.03e-03
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 5.42e-03 0.276000 3.94e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 14 7.46e-02 0.275000 2.20e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 26 1.52e-02 0.275000 7.85e-02
NUCLEAR IMPORT OF REV PROTEIN 32 7.22e-03 0.274000 4.89e-02
THE PHOTOTRANSDUCTION CASCADE 22 2.62e-02 -0.274000 1.12e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 3.01e-02 0.273000 1.22e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 1.58e-04 0.273000 2.98e-03
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 14 7.87e-02 0.271000 2.26e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.04e-01 0.271000 2.74e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 2.59e-02 0.268000 1.11e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 8.32e-02 0.267000 2.34e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 6.21e-03 0.267000 4.35e-02
GLYCOGEN SYNTHESIS 14 8.53e-02 0.266000 2.38e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 15 7.50e-02 0.266000 2.20e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 1.19e-02 0.265000 6.89e-02
RHOJ GTPASE CYCLE 55 6.80e-04 0.265000 8.61e-03
SPRY REGULATION OF FGF SIGNALING 16 6.80e-02 0.264000 2.10e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 5.30e-02 0.263000 1.81e-01
NEPHRIN FAMILY INTERACTIONS 23 2.88e-02 0.263000 1.19e-01
CELLULAR HEXOSE TRANSPORT 12 1.14e-01 0.263000 2.91e-01
AMINE LIGAND BINDING RECEPTORS 29 1.46e-02 0.262000 7.64e-02
VLDLR INTERNALISATION AND DEGRADATION 12 1.17e-01 0.261000 2.96e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 8.04e-04 0.261000 9.67e-03
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.59e-04 0.261000 2.98e-03
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.12e-02 0.261000 2.46e-01
VXPX CARGO TARGETING TO CILIUM 19 4.93e-02 0.261000 1.72e-01
RNA POLYMERASE III CHAIN ELONGATION 18 5.58e-02 -0.260000 1.86e-01
LYSINE CATABOLISM 11 1.35e-01 0.260000 3.26e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 1.25e-02 0.259000 7.12e-02
ACTIVATION OF RAC1 13 1.07e-01 0.258000 2.77e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 9.44e-02 0.258000 2.53e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 7.35e-03 0.258000 4.95e-02
P75NTR REGULATES AXONOGENESIS 10 1.59e-01 0.257000 3.59e-01
DISEASES OF DNA REPAIR 11 1.40e-01 0.257000 3.33e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.60e-01 0.257000 3.59e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 1.60e-01 0.257000 3.59e-01
CD28 DEPENDENT VAV1 PATHWAY 11 1.41e-01 0.256000 3.33e-01
PRE NOTCH PROCESSING IN GOLGI 18 6.00e-02 0.256000 1.94e-01
ERK MAPK TARGETS 22 3.78e-02 0.256000 1.45e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 15 8.77e-02 -0.255000 2.43e-01
SCAVENGING BY CLASS A RECEPTORS 14 9.94e-02 -0.254000 2.65e-01
PRC2 METHYLATES HISTONES AND DNA 32 1.28e-02 -0.254000 7.24e-02
ACYL CHAIN REMODELLING OF PE 18 6.20e-02 0.254000 1.96e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.28e-01 0.254000 3.13e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 7.54e-03 0.254000 5.02e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 3.96e-02 0.254000 1.50e-01
PHOSPHOLIPID METABOLISM 187 2.53e-09 0.253000 2.98e-07
RESPONSE OF MTB TO PHAGOCYTOSIS 21 4.57e-02 0.252000 1.64e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 1.73e-03 0.251000 1.74e-02
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 5.20e-02 0.251000 1.80e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 1.71e-01 -0.250000 3.73e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 1.51e-01 -0.250000 3.48e-01
DERMATAN SULFATE BIOSYNTHESIS 11 1.52e-01 0.249000 3.49e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.26e-02 0.249000 1.03e-01
MTOR SIGNALLING 40 6.55e-03 0.248000 4.54e-02
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.75e-01 0.248000 3.79e-01
SYNTHESIS OF PE 13 1.22e-01 0.247000 3.05e-01
DEADENYLATION OF MRNA 25 3.32e-02 0.246000 1.31e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.24e-01 -0.246000 3.08e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 2.18e-02 0.246000 1.02e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 7.15e-02 0.245000 2.17e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 1.26e-01 0.245000 3.10e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 84 1.13e-04 0.244000 2.25e-03
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 7.81e-05 0.244000 1.67e-03
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.62e-01 0.243000 3.60e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 1.45e-02 0.242000 7.61e-02
NONSENSE MEDIATED DECAY NMD 109 1.27e-05 -0.242000 5.17e-04
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 1.85e-01 -0.242000 3.92e-01
KILLING MECHANISMS 11 1.65e-01 -0.242000 3.65e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 5.56e-02 0.241000 1.86e-01
NRAGE SIGNALS DEATH THROUGH JNK 56 1.80e-03 0.241000 1.78e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 2.72e-02 0.241000 1.14e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 1.33e-01 0.241000 3.21e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 1.83e-04 0.241000 3.31e-03
TRIGLYCERIDE BIOSYNTHESIS 10 1.88e-01 0.240000 3.97e-01
RAC2 GTPASE CYCLE 88 9.90e-05 0.240000 2.05e-03
RND2 GTPASE CYCLE 39 9.65e-03 0.240000 5.94e-02
MITOTIC TELOPHASE CYTOKINESIS 13 1.35e-01 0.239000 3.26e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 27 3.16e-02 -0.239000 1.27e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 23 4.80e-02 0.238000 1.70e-01
SIGNALING BY WNT IN CANCER 31 2.19e-02 0.238000 1.02e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 9.09e-02 0.237000 2.46e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 4.51e-02 0.236000 1.62e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 1.03e-04 0.236000 2.08e-03
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 2.33e-02 0.235000 1.06e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 25 4.16e-02 -0.235000 1.55e-01
RHOC GTPASE CYCLE 74 4.72e-04 0.235000 6.47e-03
TBC RABGAPS 43 7.65e-03 0.235000 5.04e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 1.29e-01 0.235000 3.15e-01
UNWINDING OF DNA 12 1.60e-01 0.234000 3.59e-01
FORMATION OF THE CORNIFIED ENVELOPE 31 2.41e-02 -0.234000 1.07e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 2.62e-05 0.233000 8.13e-04
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 2.99e-02 0.233000 1.22e-01
PEROXISOMAL PROTEIN IMPORT 59 2.07e-03 0.232000 1.95e-02
CYTOSOLIC TRNA AMINOACYLATION 24 4.93e-02 0.232000 1.72e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 5.46e-05 0.231000 1.34e-03
INHIBITION OF DNA RECOMBINATION AT TELOMERE 38 1.37e-02 -0.231000 7.44e-02
SUMOYLATION OF SUMOYLATION PROTEINS 33 2.20e-02 0.230000 1.02e-01
MEMBRANE TRAFFICKING 581 3.89e-21 0.230000 4.58e-18
TRNA AMINOACYLATION 42 1.02e-02 0.229000 6.12e-02
RESPIRATORY ELECTRON TRANSPORT 102 6.36e-05 -0.229000 1.44e-03
ASPARAGINE N LINKED GLYCOSYLATION 285 3.16e-11 0.229000 6.20e-09
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 2.11e-01 0.228000 4.30e-01
RHOQ GTPASE CYCLE 58 2.64e-03 0.228000 2.35e-02
PYRUVATE METABOLISM 27 4.02e-02 0.228000 1.51e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 6.10e-06 0.227000 3.00e-04
LYSOSOME VESICLE BIOGENESIS 33 2.40e-02 0.227000 1.07e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 1.57e-01 0.227000 3.57e-01
HEME BIOSYNTHESIS 13 1.57e-01 0.227000 3.57e-01
OPIOID SIGNALLING 87 2.59e-04 0.227000 4.02e-03
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 2.23e-02 0.227000 1.03e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 1.58e-02 0.226000 7.98e-02
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 1.18e-07 0.226000 9.91e-06
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 1.19e-01 0.225000 2.99e-01
G0 AND EARLY G1 25 5.12e-02 0.225000 1.77e-01
REGULATION OF KIT SIGNALING 16 1.19e-01 0.225000 2.99e-01
G1 S SPECIFIC TRANSCRIPTION 26 4.70e-02 0.225000 1.67e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 3.90e-07 0.225000 2.46e-05
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 85 3.37e-04 0.225000 4.90e-03
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 1.97e-01 0.225000 4.07e-01
RMTS METHYLATE HISTONE ARGININES 46 8.36e-03 -0.225000 5.32e-02
GLYCOGEN STORAGE DISEASES 12 1.78e-01 0.225000 3.82e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 8.25e-02 0.224000 2.33e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.21e-01 0.224000 4.41e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.01e-01 -0.223000 2.68e-01
MTORC1 MEDIATED SIGNALLING 24 5.92e-02 0.223000 1.94e-01
PECAM1 INTERACTIONS 12 1.82e-01 0.222000 3.89e-01
RAB REGULATION OF TRAFFICKING 119 3.06e-05 0.221000 8.58e-04
BLOOD GROUP SYSTEMS BIOSYNTHESIS 15 1.39e-01 0.221000 3.31e-01
GAP JUNCTION DEGRADATION 11 2.06e-01 0.220000 4.21e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 6.20e-02 0.220000 1.96e-01
RHOD GTPASE CYCLE 51 6.61e-03 0.220000 4.56e-02
NUCLEAR ENVELOPE BREAKDOWN 49 7.92e-03 0.219000 5.16e-02
SIGNALLING TO ERKS 34 2.69e-02 0.219000 1.14e-01
REGULATION OF SIGNALING BY CBL 22 7.58e-02 0.219000 2.22e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 1.32e-02 0.218000 7.32e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 9.95e-02 -0.218000 2.65e-01
TIGHT JUNCTION INTERACTIONS 16 1.31e-01 0.218000 3.20e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 1.92e-01 0.218000 4.01e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 1.45e-01 0.218000 3.39e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 1.93e-01 -0.217000 4.03e-01
PLATELET CALCIUM HOMEOSTASIS 26 5.58e-02 0.217000 1.86e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 8.56e-06 0.216000 3.88e-04
HIV ELONGATION ARREST AND RECOVERY 32 3.41e-02 -0.216000 1.33e-01
RHOA GTPASE CYCLE 143 8.42e-06 0.216000 3.88e-04
GLYCOSAMINOGLYCAN METABOLISM 113 7.70e-05 0.215000 1.67e-03
METABOLISM OF COFACTORS 19 1.05e-01 -0.215000 2.74e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 3.53e-02 0.215000 1.37e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 6.82e-02 0.215000 2.10e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 13 1.80e-01 -0.215000 3.85e-01
BILE ACID AND BILE SALT METABOLISM 26 5.81e-02 0.215000 1.91e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 1.75e-02 0.214000 8.67e-02
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 1.33e-03 0.214000 1.42e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 6.91e-02 0.214000 2.12e-01
GABA RECEPTOR ACTIVATION 55 6.04e-03 0.214000 4.26e-02
SLC TRANSPORTER DISORDERS 76 1.27e-03 0.214000 1.40e-02
GOLGI TO ER RETROGRADE TRANSPORT 119 5.68e-05 0.214000 1.37e-03
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 2.70e-02 0.213000 1.14e-01
RHOBTB1 GTPASE CYCLE 23 7.70e-02 0.213000 2.23e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.02e-01 0.213000 4.16e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 102 2.10e-04 0.212000 3.50e-03
KERATINIZATION 32 3.81e-02 -0.212000 1.45e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 9.30e-02 0.212000 2.50e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 2.25e-01 0.211000 4.48e-01
SARS COV 2 INFECTION 65 3.34e-03 0.211000 2.81e-02
HDACS DEACETYLATE HISTONES 49 1.08e-02 -0.210000 6.41e-02
DARPP 32 EVENTS 23 8.09e-02 0.210000 2.29e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.13e-01 0.210000 2.88e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 50 1.02e-02 -0.210000 6.12e-02
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 1.11e-02 0.210000 6.50e-02
PLASMA LIPOPROTEIN CLEARANCE 28 5.49e-02 0.210000 1.85e-01
BUDDING AND MATURATION OF HIV VIRION 27 5.97e-02 0.209000 1.94e-01
RND1 GTPASE CYCLE 38 2.56e-02 0.209000 1.11e-01
INTERLEUKIN 17 SIGNALING 68 2.89e-03 0.209000 2.47e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.31e-01 0.208000 4.53e-01
GPVI MEDIATED ACTIVATION CASCADE 31 4.48e-02 0.208000 1.62e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 182 1.32e-06 0.208000 7.78e-05
BASE EXCISION REPAIR AP SITE FORMATION 32 4.21e-02 -0.208000 1.56e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 2.15e-01 0.207000 4.34e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 1.02e-01 0.206000 2.69e-01
SIGNALING BY BMP 25 7.46e-02 0.206000 2.20e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 1.03e-01 0.206000 2.71e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.59e-04 -0.205000 4.02e-03
TRANSMISSION ACROSS CHEMICAL SYNAPSES 244 3.71e-08 0.205000 3.65e-06
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 1.57e-01 -0.204000 3.57e-01
FATTY ACID METABOLISM 147 2.17e-05 0.203000 7.51e-04
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.26e-01 0.203000 3.10e-01
INTEGRIN SIGNALING 24 8.55e-02 0.203000 2.38e-01
SARS COV 1 INFECTION 48 1.55e-02 0.202000 7.91e-02
VESICLE MEDIATED TRANSPORT 613 1.93e-17 0.202000 7.57e-15
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 1.63e-01 0.201000 3.62e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 1.64e-01 0.201000 3.64e-01
KERATAN SULFATE BIOSYNTHESIS 24 8.88e-02 0.201000 2.44e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 5.81e-02 0.200000 1.91e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.16e-04 -0.200000 2.27e-03
EPHB MEDIATED FORWARD SIGNALING 42 2.53e-02 0.200000 1.10e-01
PENTOSE PHOSPHATE PATHWAY 13 2.13e-01 0.200000 4.33e-01
SIGNALING BY NTRK2 TRKB 24 9.09e-02 0.199000 2.46e-01
METABOLISM OF CARBOHYDRATES 260 3.48e-08 0.199000 3.65e-06
MISMATCH REPAIR 15 1.84e-01 0.198000 3.91e-01
AUTOPHAGY 138 5.92e-05 0.198000 1.39e-03
MITOTIC SPINDLE CHECKPOINT 97 7.50e-04 0.198000 9.20e-03
METABOLISM OF LIPIDS 618 5.39e-17 0.198000 1.59e-14
PURINE SALVAGE 12 2.35e-01 0.198000 4.55e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 33 4.98e-02 0.197000 1.73e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 2.02e-01 0.197000 4.16e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 49 1.72e-02 -0.197000 8.57e-02
KERATAN SULFATE KERATIN METABOLISM 30 6.27e-02 0.196000 1.97e-01
COPII MEDIATED VESICLE TRANSPORT 66 5.84e-03 0.196000 4.17e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 1.61e-01 0.196000 3.60e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 1.89e-01 0.196000 3.99e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 35 4.52e-02 -0.196000 1.62e-01
NEUROTRANSMITTER RELEASE CYCLE 49 1.79e-02 0.196000 8.76e-02
LGI ADAM INTERACTIONS 14 2.05e-01 -0.195000 4.21e-01
NETRIN 1 SIGNALING 50 1.71e-02 0.195000 8.57e-02
INTERLEUKIN 6 SIGNALING 10 2.86e-01 0.195000 5.20e-01
GABA B RECEPTOR ACTIVATION 40 3.35e-02 0.194000 1.32e-01
FCERI MEDIATED MAPK ACTIVATION 28 7.56e-02 0.194000 2.22e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 2.66e-01 0.194000 4.97e-01
RECYCLING PATHWAY OF L1 40 3.43e-02 0.193000 1.33e-01
METABOLISM OF PORPHYRINS 19 1.45e-01 0.193000 3.39e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 7.20e-02 0.193000 2.17e-01
INTERLEUKIN 37 SIGNALING 18 1.57e-01 0.193000 3.57e-01
INTEGRATION OF ENERGY METABOLISM 100 8.86e-04 0.192000 1.05e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 2.14e-02 0.192000 1.01e-01
MEIOTIC RECOMBINATION 41 3.42e-02 -0.191000 1.33e-01
PEPTIDE HORMONE METABOLISM 62 9.43e-03 0.191000 5.84e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 9.26e-02 0.191000 2.50e-01
RND3 GTPASE CYCLE 38 4.25e-02 0.190000 1.56e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 1.39e-02 0.190000 7.44e-02
FORMATION OF APOPTOSOME 10 2.99e-01 0.190000 5.34e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 1.78e-03 0.190000 1.78e-02
HS GAG BIOSYNTHESIS 30 7.26e-02 0.189000 2.17e-01
COSTIMULATION BY THE CD28 FAMILY 50 2.08e-02 0.189000 9.86e-02
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 3.03e-01 0.188000 5.38e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 3.04e-01 0.188000 5.39e-01
EUKARYOTIC TRANSLATION INITIATION 114 5.47e-04 -0.187000 7.24e-03
UNFOLDED PROTEIN RESPONSE UPR 86 2.80e-03 0.187000 2.41e-02
EFFECTS OF PIP2 HYDROLYSIS 27 9.57e-02 0.185000 2.56e-01
SIGNALING BY NTRKS 130 2.75e-04 0.185000 4.16e-03
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 97 1.73e-03 0.184000 1.74e-02
CIRCADIAN CLOCK 68 8.67e-03 0.184000 5.49e-02
RAC3 GTPASE CYCLE 91 2.42e-03 0.184000 2.23e-02
G ALPHA 12 13 SIGNALLING EVENTS 76 5.58e-03 0.184000 4.03e-02
PROCESSING AND ACTIVATION OF SUMO 10 3.15e-01 0.183000 5.51e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 2.21e-01 0.183000 4.41e-01
TRNA PROCESSING IN THE NUCLEUS 56 1.83e-02 0.182000 8.87e-02
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 2.75e-01 -0.182000 5.06e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 2.70e-03 0.182000 2.36e-02
SIALIC ACID METABOLISM 32 7.49e-02 0.182000 2.20e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 5.59e-02 0.182000 1.86e-01
CELLULAR RESPONSE TO HEAT STRESS 94 2.50e-03 0.181000 2.25e-02
MHC CLASS II ANTIGEN PRESENTATION 102 1.66e-03 0.180000 1.72e-02
RHO GTPASES ACTIVATE KTN1 11 3.01e-01 0.180000 5.37e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 193 1.62e-05 0.180000 5.97e-04
MYD88 INDEPENDENT TLR4 CASCADE 93 2.74e-03 0.180000 2.37e-02
HDR THROUGH MMEJ ALT NHEJ 10 3.25e-01 0.180000 5.64e-01
RHO GTPASES ACTIVATE FORMINS 119 7.47e-04 0.179000 9.20e-03
SYNTHESIS OF PC 26 1.14e-01 0.179000 2.91e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 3.28e-01 0.179000 5.66e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 9.05e-02 0.179000 2.46e-01
SIGNALING BY RETINOIC ACID 33 7.64e-02 0.178000 2.23e-01
RAC1 GTPASE CYCLE 180 3.80e-05 0.178000 1.03e-03
BASIGIN INTERACTIONS 22 1.48e-01 0.178000 3.42e-01
SIGNALING BY ACTIVIN 12 2.85e-01 0.178000 5.20e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 3.30e-01 0.178000 5.68e-01
INTEGRIN CELL SURFACE INTERACTIONS 75 7.90e-03 -0.177000 5.16e-02
TNF SIGNALING 43 4.42e-02 0.177000 1.60e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 6.99e-02 -0.177000 2.14e-01
DNA STRAND ELONGATION 32 8.34e-02 0.177000 2.34e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 2.70e-01 0.177000 5.02e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 1.53e-01 0.176000 3.49e-01
GP1B IX V ACTIVATION SIGNALLING 11 3.12e-01 -0.176000 5.49e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 27 1.16e-01 -0.175000 2.94e-01
CS DS DEGRADATION 14 2.58e-01 0.175000 4.85e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.47e-01 -0.175000 3.40e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 2.28e-01 0.174000 4.51e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 4.38e-02 0.174000 1.60e-01
SIGNALING BY HEDGEHOG 141 3.74e-04 0.174000 5.37e-03
SIGNALING BY VEGF 104 2.26e-03 0.173000 2.09e-02
RHO GTPASE CYCLE 425 9.74e-10 0.173000 1.64e-07
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 1.60e-01 0.173000 3.59e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.17e-01 -0.173000 4.37e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 47 4.08e-02 -0.173000 1.52e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 1.80e-02 0.172000 8.80e-02
RAB GERANYLGERANYLATION 57 2.47e-02 0.172000 1.09e-01
SIGNALING BY SCF KIT 41 5.73e-02 0.172000 1.89e-01
IRON UPTAKE AND TRANSPORT 52 3.24e-02 0.172000 1.29e-01
ERYTHROPOIETIN ACTIVATES RAS 13 2.84e-01 0.171000 5.19e-01
COLLAGEN DEGRADATION 52 3.25e-02 -0.171000 1.29e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 225 9.61e-06 0.171000 4.19e-04
SIGNALING BY MET 74 1.09e-02 0.171000 6.41e-02
TRIGLYCERIDE METABOLISM 24 1.46e-01 0.171000 3.40e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 4.72e-03 0.170000 3.59e-02
CELL CELL COMMUNICATION 106 2.66e-03 0.169000 2.36e-02
INTERLEUKIN 10 SIGNALING 20 1.91e-01 -0.169000 4.00e-01
RNA POLYMERASE I PROMOTER ESCAPE 50 3.89e-02 -0.169000 1.48e-01
G ALPHA Z SIGNALLING EVENTS 44 5.30e-02 0.169000 1.81e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.90e-02 -0.168000 9.09e-02
FGFR1 MUTANT RECEPTOR ACTIVATION 26 1.38e-01 0.168000 3.29e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 7.12e-03 0.168000 4.85e-02
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 4.72e-03 0.168000 3.59e-02
SHC MEDIATED CASCADE FGFR4 13 2.96e-01 -0.167000 5.31e-01
CARGO CONCENTRATION IN THE ER 31 1.07e-01 0.167000 2.77e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 2.63e-01 0.167000 4.93e-01
AMINO ACIDS REGULATE MTORC1 51 3.97e-02 0.167000 1.50e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 162 2.70e-04 -0.166000 4.13e-03
GLUCONEOGENESIS 27 1.36e-01 0.166000 3.28e-01
GLUCOSE METABOLISM 81 9.98e-03 0.166000 6.09e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 1.30e-01 -0.165000 3.17e-01
PROTEIN METHYLATION 17 2.40e-01 0.165000 4.60e-01
DEATH RECEPTOR SIGNALLING 134 1.01e-03 0.165000 1.15e-02
METABOLISM OF STEROIDS 116 2.22e-03 0.164000 2.08e-02
SIGNALING BY EGFR 47 5.28e-02 0.163000 1.81e-01
SIGNAL AMPLIFICATION 31 1.16e-01 0.163000 2.94e-01
SELENOAMINO ACID METABOLISM 108 3.45e-03 -0.163000 2.89e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 4.23e-02 -0.163000 1.56e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 30 1.24e-01 0.162000 3.06e-01
MUCOPOLYSACCHARIDOSES 11 3.53e-01 0.162000 5.89e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 2.43e-02 -0.162000 1.07e-01
SULFUR AMINO ACID METABOLISM 23 1.80e-01 0.161000 3.85e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 1.50e-02 0.161000 7.78e-02
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 14 2.97e-01 0.161000 5.32e-01
HYALURONAN METABOLISM 15 2.80e-01 0.161000 5.13e-01
MITOCHONDRIAL TRANSLATION 93 7.44e-03 -0.161000 4.98e-02
MITOTIC METAPHASE AND ANAPHASE 207 7.17e-05 0.160000 1.59e-03
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 1.74e-02 0.160000 8.67e-02
SEMA3A PAK DEPENDENT AXON REPULSION 16 2.69e-01 0.160000 5.01e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 3.59e-01 -0.160000 5.95e-01
REGULATION OF TNFR1 SIGNALING 34 1.07e-01 0.160000 2.78e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 2.89e-02 -0.159000 1.19e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.70e-01 -0.159000 5.02e-01
CYCLIN D ASSOCIATED EVENTS IN G1 46 6.20e-02 0.159000 1.96e-01
SENSORY PERCEPTION 158 5.96e-04 -0.158000 7.72e-03
EGFR DOWNREGULATION 28 1.47e-01 0.158000 3.40e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 3.45e-01 0.157000 5.80e-01
RHOBTB2 GTPASE CYCLE 23 1.93e-01 0.157000 4.03e-01
CDC42 GTPASE CYCLE 155 7.64e-04 0.157000 9.27e-03
REGULATION OF INSULIN SECRETION 72 2.16e-02 0.157000 1.01e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 631 2.37e-11 0.156000 5.59e-09
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 1.45e-01 0.156000 3.39e-01
NEURONAL SYSTEM 371 2.56e-07 0.156000 1.77e-05
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 3.31e-01 -0.156000 5.68e-01
PROTEIN UBIQUITINATION 70 2.42e-02 0.156000 1.07e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 2.40e-01 0.156000 4.60e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 3.71e-01 0.156000 6.09e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 2.54e-01 0.155000 4.79e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 33 1.23e-01 -0.155000 3.05e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1226 1.17e-19 0.155000 6.91e-17
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 2.33e-01 0.154000 4.54e-01
INSULIN RECEPTOR RECYCLING 20 2.35e-01 0.153000 4.54e-01
LONG TERM POTENTIATION 23 2.03e-01 0.153000 4.17e-01
PI 3K CASCADE FGFR3 13 3.39e-01 0.153000 5.75e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 5.67e-02 0.153000 1.88e-01
NUCLEOBASE CATABOLISM 31 1.42e-01 0.152000 3.34e-01
RHO GTPASES ACTIVATE PKNS 50 6.26e-02 -0.152000 1.97e-01
SIGNALING BY KIT IN DISEASE 20 2.40e-01 0.152000 4.60e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 1.60e-03 0.151000 1.68e-02
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 6.87e-03 0.151000 4.71e-02
INTERLEUKIN RECEPTOR SHC SIGNALING 20 2.44e-01 0.151000 4.63e-01
SIGNAL TRANSDUCTION BY L1 21 2.33e-01 0.150000 4.53e-01
HOST INTERACTIONS OF HIV FACTORS 125 3.70e-03 0.150000 3.00e-02
PROTEIN LOCALIZATION 158 1.14e-03 0.150000 1.27e-02
MET PROMOTES CELL MOTILITY 39 1.05e-01 0.150000 2.74e-01
CD209 DC SIGN SIGNALING 18 2.71e-01 0.150000 5.02e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 8.76e-02 0.149000 2.43e-01
G ALPHA I SIGNALLING EVENTS 204 2.52e-04 0.149000 4.01e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.67e-01 0.148000 3.67e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 182 5.84e-04 -0.148000 7.65e-03
METABOLISM OF NUCLEOTIDES 92 1.43e-02 0.148000 7.58e-02
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 5.38e-03 0.148000 3.93e-02
MYOGENESIS 25 2.02e-01 0.148000 4.16e-01
REGULATION OF BACH1 ACTIVITY 11 3.97e-01 0.148000 6.30e-01
SEROTONIN RECEPTORS 10 4.19e-01 0.147000 6.48e-01
SIGNALING BY FGFR3 35 1.32e-01 0.147000 3.20e-01
SELECTIVE AUTOPHAGY 71 3.23e-02 0.147000 1.29e-01
PROLACTIN RECEPTOR SIGNALING 11 3.99e-01 0.147000 6.31e-01
SHC1 EVENTS IN EGFR SIGNALING 11 4.03e-01 -0.146000 6.36e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 3.46e-01 0.146000 5.81e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.91e-01 0.145000 4.00e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 3.83e-01 0.145000 6.19e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 29 1.76e-01 -0.145000 3.80e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 1.08e-01 0.145000 2.78e-01
ACYL CHAIN REMODELLING OF PC 18 2.87e-01 0.145000 5.20e-01
TRANSPORT OF SMALL MOLECULES 586 2.25e-09 0.145000 2.94e-07
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.05e-01 0.144000 2.74e-01
PKMTS METHYLATE HISTONE LYSINES 51 7.46e-02 -0.144000 2.20e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 72 3.43e-02 0.144000 1.33e-01
RHOBTB GTPASE CYCLE 35 1.41e-01 0.144000 3.33e-01
PYRIMIDINE SALVAGE 10 4.31e-01 0.144000 6.56e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 2.33e-01 0.144000 4.53e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 2.05e-01 0.144000 4.20e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 4.12e-01 0.143000 6.42e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 21 2.59e-01 0.142000 4.86e-01
LAGGING STRAND SYNTHESIS 20 2.71e-01 0.142000 5.02e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 2.09e-01 0.142000 4.27e-01
RRNA PROCESSING 194 6.43e-04 -0.142000 8.23e-03
SIGNALING BY EGFR IN CANCER 22 2.49e-01 -0.142000 4.72e-01
SEPARATION OF SISTER CHROMATIDS 166 1.62e-03 0.142000 1.69e-02
SNRNP ASSEMBLY 51 8.08e-02 0.141000 2.29e-01
RNA POLYMERASE III TRANSCRIPTION 41 1.18e-01 -0.141000 2.97e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 4.39e-01 0.141000 6.57e-01
ONCOGENIC MAPK SIGNALING 77 3.23e-02 0.141000 1.29e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.14e-01 0.141000 4.33e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 3.66e-02 0.141000 1.41e-01
SIGNALING BY GPCR 486 1.28e-07 0.140000 1.00e-05
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 4.44e-01 0.140000 6.62e-01
NOD1 2 SIGNALING PATHWAY 35 1.52e-01 0.140000 3.49e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.42e-01 -0.140000 3.34e-01
SIGNALING BY FGFR2 IN DISEASE 37 1.42e-01 -0.139000 3.34e-01
MITOPHAGY 29 1.94e-01 0.139000 4.03e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 6.25e-02 0.139000 1.97e-01
PLASMA LIPOPROTEIN REMODELING 14 3.69e-01 0.139000 6.06e-01
TOLL LIKE RECEPTOR CASCADES 139 4.89e-03 0.138000 3.67e-02
CELLULAR RESPONSE TO STARVATION 146 4.03e-03 -0.138000 3.18e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 6.06e-02 0.138000 1.94e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 24 2.43e-01 0.138000 4.63e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 2.65e-01 0.137000 4.96e-01
NUCLEOTIDE SALVAGE 21 2.76e-01 0.137000 5.08e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 85 2.99e-02 0.136000 1.22e-01
SIGNALING BY FGFR1 IN DISEASE 33 1.77e-01 0.136000 3.81e-01
MITOTIC PROMETAPHASE 177 1.94e-03 0.135000 1.87e-02
INFLUENZA INFECTION 145 5.07e-03 -0.135000 3.78e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 3.10e-01 0.135000 5.46e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 7.45e-02 0.134000 2.20e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 2.29e-01 0.134000 4.52e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 4.04e-01 -0.134000 6.36e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 3.01e-01 0.134000 5.37e-01
CELL JUNCTION ORGANIZATION 73 4.88e-02 0.133000 1.72e-01
METABOLISM OF VITAMINS AND COFACTORS 152 4.62e-03 0.133000 3.56e-02
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 40 1.46e-01 -0.133000 3.39e-01
NEDDYLATION 217 7.47e-04 0.133000 9.20e-03
EPH EPHRIN SIGNALING 92 2.76e-02 0.133000 1.16e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 1.93e-01 0.133000 4.03e-01
ION TRANSPORT BY P TYPE ATPASES 50 1.05e-01 0.133000 2.74e-01
PEXOPHAGY 11 4.47e-01 0.132000 6.65e-01
ESTROGEN DEPENDENT GENE EXPRESSION 107 1.85e-02 -0.132000 8.96e-02
BASE EXCISION REPAIR 60 7.75e-02 -0.132000 2.24e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 2.46e-01 -0.131000 4.68e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 2.29e-01 0.131000 4.52e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 2.31e-01 -0.131000 4.53e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 2.33e-01 -0.130000 4.53e-01
CROSSLINKING OF COLLAGEN FIBRILS 15 3.82e-01 -0.130000 6.18e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 4.78e-01 -0.129000 6.92e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 4.59e-01 0.129000 6.79e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 1.44e-01 0.129000 3.39e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 6.71e-02 0.128000 2.08e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 94 3.17e-02 0.128000 1.27e-01
BIOLOGICAL OXIDATIONS 126 1.30e-02 0.128000 7.24e-02
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.66e-01 0.128000 3.65e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 3.34e-01 -0.128000 5.71e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 4.07e-01 0.128000 6.37e-01
NEUTROPHIL DEGRANULATION 389 1.76e-05 0.127000 6.29e-04
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 3.26e-01 0.127000 5.64e-01
CGMP EFFECTS 15 3.96e-01 -0.127000 6.29e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 3.96e-01 0.127000 6.29e-01
SIGNALING BY PTK6 51 1.19e-01 0.126000 2.99e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 1.53e-01 -0.126000 3.49e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 68 7.26e-02 -0.126000 2.17e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 1.20e-01 0.126000 3.01e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 4.71e-01 0.126000 6.88e-01
PHASE II CONJUGATION OF COMPOUNDS 64 8.24e-02 0.126000 2.33e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 6.40e-02 0.125000 2.00e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 4.35e-01 -0.125000 6.57e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 4.54e-01 0.125000 6.74e-01
HEMOSTASIS 479 3.09e-06 0.125000 1.65e-04
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 1.67e-01 0.125000 3.67e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 4.38e-01 -0.124000 6.57e-01
CELL CELL JUNCTION ORGANIZATION 48 1.38e-01 0.124000 3.30e-01
ADHERENS JUNCTIONS INTERACTIONS 30 2.41e-01 0.124000 4.61e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 2.13e-01 0.123000 4.33e-01
S PHASE 155 8.06e-03 0.123000 5.22e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.42e-01 -0.123000 5.77e-01
GLYCOLYSIS 67 8.29e-02 0.123000 2.34e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 2.17e-01 0.122000 4.37e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 69 7.98e-02 -0.122000 2.29e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 4.65e-01 0.122000 6.83e-01
TRIGLYCERIDE CATABOLISM 14 4.31e-01 0.122000 6.56e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 2.28e-01 0.121000 4.51e-01
REPRODUCTION 80 6.14e-02 -0.121000 1.96e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 3.74e-01 0.121000 6.11e-01
PI3K AKT SIGNALING IN CANCER 91 4.63e-02 0.121000 1.65e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 3.38e-01 0.121000 5.75e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 5.46e-02 0.121000 1.84e-01
PLASMA LIPOPROTEIN ASSEMBLY 12 4.69e-01 0.121000 6.88e-01
G ALPHA Q SIGNALLING EVENTS 155 9.68e-03 0.120000 5.94e-02
SUMOYLATION OF TRANSCRIPTION FACTORS 18 3.77e-01 -0.120000 6.11e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 4.73e-01 0.120000 6.89e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 143 1.38e-02 0.119000 7.44e-02
RRNA PROCESSING IN THE MITOCHONDRION 10 5.13e-01 0.119000 7.11e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 52 1.37e-01 -0.119000 3.28e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 3.22e-01 -0.119000 5.60e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 2.93e-01 0.119000 5.30e-01
HEDGEHOG ON STATE 82 6.41e-02 0.118000 2.00e-01
HIV INFECTION 221 2.48e-03 0.118000 2.24e-02
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 3.07e-01 0.118000 5.42e-01
ATTENUATION PHASE 23 3.28e-01 -0.118000 5.66e-01
CRISTAE FORMATION 31 2.57e-01 -0.118000 4.85e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.74e-01 0.117000 5.06e-01
PREGNENOLONE BIOSYNTHESIS 12 4.82e-01 -0.117000 6.95e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.89e-01 0.117000 6.24e-01
MICRORNA MIRNA BIOGENESIS 24 3.20e-01 -0.117000 5.58e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 4.65e-01 0.117000 6.83e-01
SIGNALLING TO RAS 20 3.65e-01 0.117000 6.02e-01
SHC MEDIATED CASCADE FGFR1 16 4.19e-01 -0.117000 6.48e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 4.06e-01 0.116000 6.37e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 3.05e-01 0.116000 5.40e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 5.05e-01 -0.116000 7.07e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 4.36e-01 0.116000 6.57e-01
REGULATION OF FZD BY UBIQUITINATION 19 3.82e-01 0.116000 6.18e-01
ECM PROTEOGLYCANS 68 9.94e-02 -0.116000 2.65e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 4.39e-01 0.116000 6.57e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 1.80e-01 0.115000 3.85e-01
INITIAL TRIGGERING OF COMPLEMENT 12 4.90e-01 0.115000 6.97e-01
TIE2 SIGNALING 17 4.13e-01 0.115000 6.42e-01
O LINKED GLYCOSYLATION 86 6.63e-02 0.115000 2.06e-01
ERBB2 ACTIVATES PTK6 SIGNALING 12 4.92e-01 0.114000 6.98e-01
ION HOMEOSTASIS 50 1.62e-01 0.114000 3.60e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 466 2.60e-05 0.114000 8.13e-04
INNATE IMMUNE SYSTEM 784 7.87e-08 0.113000 7.13e-06
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 5.16e-01 0.113000 7.12e-01
SODIUM CALCIUM EXCHANGERS 10 5.37e-01 0.113000 7.29e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 68 1.10e-01 0.112000 2.83e-01
EARLY PHASE OF HIV LIFE CYCLE 13 4.86e-01 -0.112000 6.95e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 4.40e-01 -0.112000 6.58e-01
COLLAGEN FORMATION 79 8.79e-02 -0.111000 2.43e-01
DISEASES OF PROGRAMMED CELL DEATH 57 1.47e-01 -0.111000 3.40e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 2.49e-01 0.111000 4.72e-01
TRANSLESION SYNTHESIS BY POLK 17 4.29e-01 -0.111000 6.56e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 284 1.32e-03 0.111000 1.42e-02
GLUTATHIONE CONJUGATION 30 2.94e-01 0.111000 5.30e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 1.71e-01 0.111000 3.73e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 5.44e-01 0.111000 7.31e-01
RNA POLYMERASE I TRANSCRIPTION 70 1.10e-01 -0.111000 2.83e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 17 4.30e-01 -0.110000 6.56e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 4.32e-01 0.110000 6.56e-01
SARS COV INFECTIONS 140 2.49e-02 0.110000 1.09e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 5.10e-01 -0.110000 7.09e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 2.41e-01 0.108000 4.61e-01
HIV TRANSCRIPTION ELONGATION 42 2.25e-01 -0.108000 4.48e-01
ADAPTIVE IMMUNE SYSTEM 610 5.52e-06 0.108000 2.83e-04
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 4.72e-01 0.107000 6.89e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 64 1.38e-01 0.107000 3.29e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 5.40e-01 0.107000 7.29e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 5.41e-01 -0.106000 7.29e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 3.30e-01 0.106000 5.68e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 86 8.89e-02 -0.106000 2.44e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 4.92e-01 -0.106000 6.98e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 4.77e-01 0.106000 6.92e-01
NUCLEAR SIGNALING BY ERBB4 31 3.07e-01 0.106000 5.42e-01
RHO GTPASES ACTIVATE CIT 18 4.39e-01 -0.105000 6.57e-01
ERBB2 REGULATES CELL MOTILITY 14 4.95e-01 0.105000 7.01e-01
PHASE 0 RAPID DEPOLARISATION 28 3.39e-01 -0.104000 5.75e-01
NICOTINATE METABOLISM 24 3.77e-01 0.104000 6.11e-01
RHO GTPASE EFFECTORS 253 4.40e-03 0.104000 3.41e-02
RHO GTPASES ACTIVATE IQGAPS 24 3.78e-01 0.104000 6.12e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 8.02e-02 0.104000 2.29e-01
SIGNALING BY NTRK3 TRKC 17 4.60e-01 -0.104000 6.80e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 2.68e-03 0.103000 2.36e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 4.36e-01 0.103000 6.57e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 2.79e-01 0.103000 5.12e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 5.22e-01 -0.103000 7.14e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 5.07e-02 0.102000 1.76e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 4.30e-01 0.102000 6.56e-01
HEDGEHOG LIGAND BIOGENESIS 61 1.70e-01 0.102000 3.71e-01
DISEASES OF METABOLISM 198 1.42e-02 0.101000 7.58e-02
SMOOTH MUSCLE CONTRACTION 33 3.15e-01 -0.101000 5.51e-01
M PHASE 343 1.33e-03 0.101000 1.42e-02
EPIGENETIC REGULATION OF GENE EXPRESSION 106 7.27e-02 -0.101000 2.17e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 1.84e-01 0.101000 3.91e-01
L1CAM INTERACTIONS 108 7.08e-02 0.101000 2.16e-01
HCMV INFECTION 106 7.36e-02 0.101000 2.19e-01
POLYMERASE SWITCHING 14 5.15e-01 0.101000 7.11e-01
PLATELET AGGREGATION PLUG FORMATION 32 3.25e-01 0.101000 5.64e-01
SIGNALING BY ROBO RECEPTORS 207 1.29e-02 -0.100000 7.24e-02
G PROTEIN ACTIVATION 23 4.05e-01 -0.100000 6.37e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 9.90e-04 0.100000 1.14e-02
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 3.14e-01 0.099800 5.51e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 5.85e-01 -0.099700 7.64e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 5.51e-01 -0.099500 7.36e-01
MITOTIC PROPHASE 97 9.10e-02 0.099400 2.46e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 9.11e-02 0.099300 2.46e-01
CELL CYCLE MITOTIC 479 2.11e-04 0.099100 3.50e-03
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.08e-01 -0.098600 7.07e-01
SIGNALING BY LEPTIN 10 5.90e-01 0.098500 7.65e-01
P38MAPK EVENTS 13 5.39e-01 0.098400 7.29e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 2.16e-01 0.098300 4.35e-01
REPRESSION OF WNT TARGET GENES 14 5.25e-01 -0.098200 7.15e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 3.38e-01 -0.097800 5.75e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 92 1.05e-01 0.097800 2.74e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 4.62e-01 -0.097500 6.81e-01
FGFR1 LIGAND BINDING AND ACTIVATION 10 5.94e-01 -0.097300 7.67e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 4.63e-01 0.097200 6.81e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 347 2.07e-03 0.096400 1.95e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH 62 1.90e-01 -0.096300 4.00e-01
HEDGEHOG OFF STATE 106 8.80e-02 0.096000 2.43e-01
REGULATION OF IFNA SIGNALING 12 5.65e-01 0.096000 7.50e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 3.20e-01 0.095800 5.58e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 4.63e-01 0.094800 6.81e-01
NEUREXINS AND NEUROLIGINS 54 2.28e-01 0.094800 4.51e-01
RHO GTPASES ACTIVATE ROCKS 19 4.75e-01 -0.094700 6.91e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 5.71e-01 0.094400 7.54e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 3.68e-01 0.093400 6.05e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 4.20e-01 -0.093200 6.48e-01
TRP CHANNELS 20 4.71e-01 0.093200 6.88e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 3.58e-01 0.092500 5.94e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 4.74e-01 0.092400 6.91e-01
ANCHORING FIBRIL FORMATION 14 5.50e-01 -0.092300 7.36e-01
SIGNALING BY FGFR4 34 3.52e-01 0.092300 5.87e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 3.99e-01 0.092200 6.31e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 3.69e-01 0.091900 6.05e-01
LEISHMANIA INFECTION 198 2.68e-02 0.091400 1.14e-01
REGULATION OF TP53 ACTIVITY 152 5.25e-02 0.091200 1.81e-01
INWARDLY RECTIFYING K CHANNELS 32 3.74e-01 0.090900 6.11e-01
SIGNALING BY ERBB2 49 2.72e-01 0.090800 5.02e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 4.96e-01 -0.090300 7.01e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 5.20e-01 -0.090100 7.14e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 4.88e-01 -0.089600 6.96e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 2.19e-01 0.089500 4.39e-01
GPCR LIGAND BINDING 270 1.16e-02 0.089400 6.71e-02
RHOH GTPASE CYCLE 37 3.47e-01 0.089300 5.82e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 58 2.40e-01 0.089300 4.60e-01
SIGNALING BY INSULIN RECEPTOR 65 2.14e-01 0.089200 4.33e-01
LAMININ INTERACTIONS 29 4.07e-01 -0.089100 6.37e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 62 2.26e-01 0.089000 4.48e-01
SIGNALING BY FGFR4 IN DISEASE 11 6.10e-01 -0.088900 7.76e-01
PROCESSING OF SMDT1 16 5.39e-01 0.088800 7.29e-01
RORA ACTIVATES GENE EXPRESSION 18 5.14e-01 0.088800 7.11e-01
ION CHANNEL TRANSPORT 143 6.79e-02 0.088500 2.10e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.96e-01 -0.088400 7.68e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 6.12e-01 -0.088300 7.76e-01
DISEASES OF GLYCOSYLATION 124 9.01e-02 0.088200 2.46e-01
PLATELET HOMEOSTASIS 78 1.79e-01 0.088100 3.84e-01
HIV LIFE CYCLE 142 7.13e-02 0.087800 2.16e-01
TELOMERE MAINTENANCE 81 1.72e-01 -0.087700 3.75e-01
FLT3 SIGNALING 36 3.64e-01 0.087500 6.00e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 5.85e-01 -0.087500 7.64e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 3.93e-01 -0.087200 6.28e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 4.18e-01 0.086900 6.48e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 3.96e-01 0.086800 6.29e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.99e-01 0.086700 5.34e-01
SIGNALING BY NOTCH3 48 3.02e-01 0.086100 5.37e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 5.07e-01 0.085700 7.07e-01
KERATAN SULFATE DEGRADATION 11 6.23e-01 0.085500 7.85e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 4.98e-01 -0.085400 7.02e-01
ONCOGENE INDUCED SENESCENCE 32 4.07e-01 0.084600 6.37e-01
MAPK FAMILY SIGNALING CASCADES 290 1.33e-02 0.084600 7.33e-02
TRANSLESION SYNTHESIS BY POLH 19 5.25e-01 -0.084300 7.15e-01
ACYL CHAIN REMODELLING OF PS 14 5.87e-01 0.083900 7.64e-01
HCMV LATE EVENTS 68 2.32e-01 0.083800 4.53e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 23 4.88e-01 -0.083600 6.96e-01
OXIDATIVE STRESS INDUCED SENESCENCE 81 1.96e-01 -0.083100 4.07e-01
CHOLESTEROL BIOSYNTHESIS 24 4.84e-01 0.082600 6.95e-01
RUNX3 REGULATES NOTCH SIGNALING 13 6.07e-01 0.082500 7.74e-01
ABC TRANSPORTER DISORDERS 70 2.34e-01 0.082300 4.54e-01
PYROPTOSIS 21 5.15e-01 -0.082200 7.11e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 3.41e-01 0.082100 5.76e-01
VIRAL MESSENGER RNA SYNTHESIS 42 3.60e-01 0.081600 5.96e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 33 4.20e-01 -0.081100 6.48e-01
INTERLEUKIN 1 FAMILY SIGNALING 123 1.21e-01 0.081000 3.02e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 5.75e-01 -0.081000 7.57e-01
FRS MEDIATED FGFR3 SIGNALING 15 5.87e-01 0.081000 7.64e-01
AMYLOID FIBER FORMATION 61 2.74e-01 -0.081000 5.06e-01
NEGATIVE REGULATION OF FLT3 14 6.01e-01 0.080600 7.71e-01
INTERLEUKIN 1 SIGNALING 96 1.73e-01 0.080500 3.75e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 1.58e-01 0.080500 3.58e-01
SIGNALING BY FGFR1 44 3.56e-01 0.080500 5.91e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 2.87e-01 -0.080100 5.21e-01
AQUAPORIN MEDIATED TRANSPORT 41 3.76e-01 0.080000 6.11e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 29 4.57e-01 0.079800 6.77e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 4.50e-01 0.079700 6.68e-01
METABOLISM OF POLYAMINES 57 3.02e-01 0.079100 5.37e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 5.51e-01 0.079000 7.36e-01
VISUAL PHOTOTRANSDUCTION 61 2.89e-01 -0.078500 5.23e-01
UB SPECIFIC PROCESSING PROTEASES 167 8.08e-02 0.078400 2.29e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 6.53e-01 0.078300 8.09e-01
NICOTINAMIDE SALVAGING 15 6.00e-01 0.078100 7.71e-01
DNA REPLICATION PRE INITIATION 80 2.30e-01 0.077700 4.52e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 4.85e-01 -0.077700 6.95e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 5.38e-01 0.077700 7.29e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 2.19e-01 -0.077700 4.39e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 13 6.28e-01 -0.077600 7.90e-01
DNA DAMAGE RECOGNITION IN GG NER 38 4.09e-01 0.077400 6.39e-01
SIGNALING BY INTERLEUKINS 351 1.34e-02 0.077000 7.33e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 79 2.40e-01 0.076600 4.60e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 5.01e-01 0.076200 7.05e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 4.14e-01 -0.075600 6.43e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 2.50e-01 0.075400 4.73e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 5.82e-01 0.075000 7.64e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.83e-01 0.074700 8.30e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 3.49e-01 0.074400 5.84e-01
FGFR2 ALTERNATIVE SPLICING 25 5.21e-01 -0.074200 7.14e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 4.84e-01 0.073900 6.95e-01
CILIUM ASSEMBLY 192 7.88e-02 0.073600 2.26e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 5.70e-01 0.073400 7.54e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 118 1.69e-01 0.073300 3.71e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 111 1.84e-01 -0.073000 3.91e-01
SIGNALING BY ERBB4 57 3.41e-01 0.072900 5.76e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 6.14e-01 -0.072900 7.76e-01
CELL CYCLE 597 2.45e-03 0.072800 2.23e-02
DEUBIQUITINATION 241 5.30e-02 0.072400 1.81e-01
METAL ION SLC TRANSPORTERS 25 5.32e-01 0.072200 7.24e-01
SIGNALING BY NOTCH1 75 2.81e-01 0.072000 5.14e-01
TRANSLATION 286 3.66e-02 -0.071900 1.41e-01
REGULATED NECROSIS 46 3.99e-01 -0.071900 6.31e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 3.14e-01 0.071700 5.51e-01
REGULATED PROTEOLYSIS OF P75NTR 12 6.68e-01 0.071400 8.24e-01
SIGNALING BY FGFR2 IIIA TM 19 5.90e-01 -0.071400 7.65e-01
CELL CYCLE CHECKPOINTS 245 5.45e-02 0.071400 1.84e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 5.72e-01 0.071300 7.54e-01
DNA REPLICATION 122 1.75e-01 0.071100 3.79e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 6.12e-01 0.071100 7.76e-01
FRS MEDIATED FGFR2 SIGNALING 19 5.92e-01 -0.070900 7.66e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 5.56e-01 0.070900 7.42e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.84e-01 0.070700 7.64e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.23e-01 0.070700 6.50e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.00e-01 0.070300 8.45e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 6.76e-01 0.069800 8.26e-01
METABOLISM OF FOLATE AND PTERINES 15 6.43e-01 0.069100 8.03e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 5.06e-01 -0.069000 7.07e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 5.43e-01 0.068900 7.31e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 5.22e-01 -0.068700 7.14e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 5.63e-01 -0.068300 7.48e-01
REGULATION OF RAS BY GAPS 66 3.38e-01 0.068200 5.75e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 6.71e-01 0.068100 8.26e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 66 3.39e-01 -0.068100 5.75e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 6.71e-01 0.067900 8.26e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 46 4.27e-01 -0.067600 6.56e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 5.84e-01 0.067400 7.64e-01
TRAFFICKING OF AMPA RECEPTORS 31 5.17e-01 0.067300 7.12e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 4.97e-01 0.067300 7.02e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 64 3.55e-01 -0.066900 5.90e-01
MEIOSIS 67 3.44e-01 -0.066900 5.79e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 6.76e-01 -0.066800 8.26e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 7.02e-01 0.066700 8.45e-01
INSULIN RECEPTOR SIGNALLING CASCADE 46 4.35e-01 0.066600 6.57e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 152 1.62e-01 -0.065800 3.60e-01
GENE SILENCING BY RNA 85 2.95e-01 -0.065700 5.31e-01
G2 M DNA DAMAGE CHECKPOINT 69 3.47e-01 -0.065500 5.82e-01
KINESINS 47 4.39e-01 0.065200 6.57e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 187 1.26e-01 0.064900 3.11e-01
DSCAM INTERACTIONS 11 7.10e-01 0.064700 8.49e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 6.98e-01 -0.064600 8.45e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 3.96e-01 0.064500 6.29e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 5.93e-01 0.064300 7.66e-01
CHROMOSOME MAINTENANCE 104 2.59e-01 -0.064000 4.87e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 5.88e-01 -0.063800 7.65e-01
INTERFERON ALPHA BETA SIGNALING 54 4.17e-01 -0.063800 6.47e-01
INTERLEUKIN 7 SIGNALING 19 6.31e-01 -0.063700 7.91e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 6.16e-01 0.063200 7.78e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 4.23e-01 0.063100 6.50e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 5.85e-01 -0.063000 7.64e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 6.44e-01 -0.062900 8.03e-01
PYRIMIDINE CATABOLISM 10 7.32e-01 -0.062600 8.70e-01
RESOLUTION OF D LOOP STRUCTURES 31 5.48e-01 -0.062300 7.35e-01
RET SIGNALING 38 5.08e-01 0.062000 7.07e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 317 5.99e-02 0.061600 1.94e-01
PURINE CATABOLISM 16 6.71e-01 0.061300 8.26e-01
TRNA PROCESSING 105 2.78e-01 0.061300 5.10e-01
MEIOTIC SYNAPSIS 43 4.98e-01 -0.059700 7.02e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 549 1.76e-02 0.059400 8.69e-02
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 60 4.27e-01 0.059400 6.55e-01
MRNA SPLICING 188 1.62e-01 -0.059200 3.60e-01
STRIATED MUSCLE CONTRACTION 26 6.05e-01 -0.058600 7.73e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 6.95e-01 0.058500 8.42e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.30e-01 0.058100 7.91e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 6.04e-01 0.057700 7.73e-01
VOLTAGE GATED POTASSIUM CHANNELS 38 5.39e-01 0.057700 7.29e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 6.12e-01 0.057500 7.76e-01
C TYPE LECTIN RECEPTORS CLRS 112 2.95e-01 0.057400 5.31e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 4.47e-01 -0.057300 6.65e-01
CRMPS IN SEMA3A SIGNALING 16 6.92e-01 -0.057100 8.40e-01
RESOLUTION OF ABASIC SITES AP SITES 38 5.43e-01 -0.057100 7.31e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 6.75e-01 0.057000 8.26e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 6.08e-01 0.057000 7.76e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 7.57e-01 0.056500 8.85e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 5.75e-01 -0.056400 7.57e-01
HCMV EARLY EVENTS 83 3.77e-01 0.056100 6.11e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 7.47e-01 0.056100 8.79e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 74 4.08e-01 -0.055700 6.37e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.61e-01 0.055300 8.18e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 4.61e-01 -0.054600 6.81e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.68e-01 0.054300 7.53e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 5.38e-01 0.054300 7.29e-01
G ALPHA S SIGNALLING EVENTS 107 3.33e-01 0.054200 5.71e-01
SIGNALING BY NOTCH2 33 5.92e-01 0.054000 7.66e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 6.05e-01 0.053700 7.73e-01
PROTEIN FOLDING 90 3.86e-01 0.052900 6.21e-01
GAP JUNCTION ASSEMBLY 21 6.75e-01 0.052800 8.26e-01
INFECTIOUS DISEASE 736 1.53e-02 0.052700 7.85e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.35e-01 -0.052600 4.54e-01
TP53 REGULATES METABOLIC GENES 85 4.03e-01 -0.052500 6.36e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 5.13e-01 0.052500 7.11e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 284 1.31e-01 0.052100 3.20e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 4.89e-01 0.052100 6.97e-01
IRAK4 DEFICIENCY TLR2 4 14 7.36e-01 -0.052000 8.73e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 5.89e-01 0.052000 7.65e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 33 6.11e-01 0.051200 7.76e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 6.01e-01 -0.051100 7.71e-01
CARDIAC CONDUCTION 107 3.62e-01 0.051000 5.98e-01
RAS PROCESSING 24 6.66e-01 0.050900 8.23e-01
MATURATION OF NUCLEOPROTEIN 10 7.81e-01 -0.050800 8.94e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 6.74e-01 0.050700 8.26e-01
TCR SIGNALING 101 3.84e-01 0.050100 6.19e-01
TNFR2 NON CANONICAL NF KB PATHWAY 82 4.35e-01 0.049800 6.57e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 4.36e-01 0.049200 6.57e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 5.21e-01 -0.049100 7.14e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 7.43e-01 -0.048900 8.79e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 7.53e-01 0.048500 8.83e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 6.76e-01 -0.048300 8.26e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 6.85e-01 0.047800 8.32e-01
OTHER SEMAPHORIN INTERACTIONS 19 7.19e-01 -0.047700 8.55e-01
HOMOLOGY DIRECTED REPAIR 111 3.86e-01 -0.047600 6.21e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 7.66e-01 0.047600 8.88e-01
PRE NOTCH EXPRESSION AND PROCESSING 67 5.01e-01 -0.047600 7.05e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 94 4.31e-01 0.047000 6.56e-01
EXTENSION OF TELOMERES 49 5.70e-01 0.046900 7.54e-01
APOPTOTIC EXECUTION PHASE 45 5.87e-01 0.046800 7.64e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 5.18e-01 0.046800 7.13e-01
INTERFERON GAMMA SIGNALING 76 4.83e-01 -0.046500 6.95e-01
GAB1 SIGNALOSOME 14 7.64e-01 0.046400 8.87e-01
STIMULI SENSING CHANNELS 76 4.85e-01 0.046300 6.95e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 5.40e-01 -0.046100 7.29e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 7.58e-01 0.045900 8.85e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 6.48e-01 0.045900 8.07e-01
FCERI MEDIATED NF KB ACTIVATION 76 4.91e-01 0.045700 6.97e-01
CYTOPROTECTION BY HMOX1 120 3.88e-01 -0.045700 6.22e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 6.99e-01 -0.045600 8.45e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 7.77e-01 0.045300 8.94e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 7.09e-01 0.045000 8.49e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 7.64e-01 -0.044800 8.87e-01
ENDOSOMAL VACUOLAR PATHWAY 10 8.06e-01 0.044800 9.14e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 7.82e-01 -0.044300 8.94e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 7.69e-01 -0.043900 8.89e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 6.73e-01 -0.043800 8.26e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 64 5.45e-01 -0.043800 7.31e-01
MAP2K AND MAPK ACTIVATION 36 6.50e-01 0.043600 8.09e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 7.13e-01 0.043500 8.51e-01
ZINC TRANSPORTERS 16 7.64e-01 0.043400 8.87e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 6.48e-01 -0.043400 8.07e-01
PCP CE PATHWAY 89 4.80e-01 0.043300 6.94e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 5.07e-01 0.043200 7.07e-01
UCH PROTEINASES 89 4.83e-01 -0.043000 6.95e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 6.79e-01 0.043000 8.27e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 7.61e-01 -0.042700 8.87e-01
COMPLEMENT CASCADE 26 7.08e-01 0.042400 8.49e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 8.10e-01 -0.041900 9.14e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 5.98e-01 -0.041900 7.70e-01
FRS MEDIATED FGFR4 SIGNALING 15 7.80e-01 -0.041700 8.94e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 7.81e-01 -0.041500 8.94e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 5.20e-01 0.041300 7.14e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 6.22e-01 0.041100 7.84e-01
POTASSIUM CHANNELS 90 5.03e-01 0.040900 7.06e-01
SIGNALING BY PDGFR IN DISEASE 20 7.52e-01 0.040800 8.83e-01
PROGRAMMED CELL DEATH 186 3.38e-01 0.040800 5.75e-01
IRS MEDIATED SIGNALLING 41 6.52e-01 0.040700 8.09e-01
HDMS DEMETHYLATE HISTONES 30 7.01e-01 -0.040500 8.45e-01
INTRAFLAGELLAR TRANSPORT 52 6.14e-01 0.040400 7.76e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 5.57e-01 0.040000 7.42e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 7.35e-01 0.039900 8.73e-01
SUMOYLATION 168 3.74e-01 0.039800 6.11e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 7.97e-01 0.039700 9.05e-01
CLEC7A DECTIN 1 SIGNALING 94 5.08e-01 0.039500 7.07e-01
DNA DOUBLE STRAND BREAK RESPONSE 55 6.13e-01 0.039400 7.76e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 4.86e-01 0.038800 6.95e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 7.45e-01 -0.038300 8.79e-01
ASSEMBLY OF THE HIV VIRION 16 7.91e-01 0.038200 9.02e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 6.18e-01 -0.038200 7.79e-01
METHYLATION 11 8.29e-01 0.037700 9.23e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 8.08e-01 0.037600 9.14e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 8.39e-01 -0.037100 9.27e-01
METABOLISM OF STEROID HORMONES 21 7.71e-01 0.036700 8.90e-01
CHROMATIN MODIFYING ENZYMES 222 3.48e-01 -0.036600 5.82e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 8.21e-01 0.036300 9.19e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 5.61e-01 -0.035800 7.47e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 7.57e-01 -0.035700 8.85e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 5.78e-01 0.035500 7.60e-01
INTERFERON SIGNALING 164 4.36e-01 0.035300 6.57e-01
ELASTIC FIBRE FORMATION 38 7.09e-01 0.035000 8.49e-01
METABOLISM OF RNA 645 1.32e-01 -0.034900 3.20e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 8.30e-01 0.034500 9.23e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 8.20e-01 0.033900 9.19e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 8.53e-01 -0.033700 9.35e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 7.41e-01 -0.033700 8.79e-01
PI 3K CASCADE FGFR2 17 8.10e-01 -0.033600 9.14e-01
PTEN REGULATION 133 5.07e-01 0.033300 7.07e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 6.02e-01 0.032800 7.71e-01
DISEASES OF IMMUNE SYSTEM 26 7.73e-01 -0.032800 8.91e-01
HSF1 DEPENDENT TRANSACTIVATION 33 7.47e-01 0.032500 8.79e-01
G1 S DNA DAMAGE CHECKPOINTS 65 6.52e-01 -0.032300 8.09e-01
APOPTOSIS 164 4.76e-01 0.032300 6.91e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 7.91e-01 0.031900 9.02e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 8.43e-01 0.031700 9.30e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 7.69e-01 0.031500 8.89e-01
ENOS ACTIVATION 11 8.60e-01 0.030700 9.36e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 8.66e-01 0.030700 9.39e-01
MITOTIC G2 G2 M PHASES 184 4.76e-01 0.030500 6.91e-01
SIGNALING BY WNT 272 3.91e-01 0.030200 6.27e-01
INFLAMMASOMES 19 8.21e-01 0.030000 9.19e-01
HSF1 ACTIVATION 25 7.96e-01 -0.029800 9.05e-01
DUAL INCISION IN TC NER 65 6.78e-01 -0.029800 8.27e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 6.82e-01 0.029700 8.29e-01
POTENTIAL THERAPEUTICS FOR SARS 77 6.53e-01 0.029700 8.09e-01
SIGNALING BY NUCLEAR RECEPTORS 228 4.45e-01 0.029400 6.63e-01
PHOSPHORYLATION OF THE APC C 17 8.36e-01 0.029100 9.27e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 7.48e-01 -0.029100 8.79e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 6.42e-01 0.029000 8.03e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 8.52e-01 -0.028800 9.35e-01
PI 3K CASCADE FGFR1 16 8.42e-01 0.028700 9.30e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 15 8.48e-01 0.028500 9.33e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 7.10e-01 0.028500 8.49e-01
CA2 PATHWAY 59 7.09e-01 -0.028100 8.49e-01
MITOCHONDRIAL PROTEIN IMPORT 63 7.00e-01 0.028100 8.45e-01
INTERLEUKIN 15 SIGNALING 12 8.69e-01 -0.027600 9.39e-01
PHASE 2 PLATEAU PHASE 10 8.81e-01 -0.027400 9.43e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 8.33e-01 0.027200 9.26e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.55e-01 -0.026400 9.35e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 8.69e-01 0.026400 9.39e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 8.70e-01 -0.026200 9.39e-01
MRNA SPLICING MINOR PATHWAY 52 7.44e-01 -0.026200 8.79e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 7.15e-01 -0.026000 8.52e-01
SHC MEDIATED CASCADE FGFR3 13 8.72e-01 -0.025900 9.39e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 8.67e-01 -0.025800 9.39e-01
P75NTR SIGNALS VIA NF KB 16 8.59e-01 -0.025600 9.36e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 7.65e-01 0.025500 8.87e-01
SIGNALING BY ERBB2 IN CANCER 25 8.26e-01 0.025400 9.21e-01
NGF STIMULATED TRANSCRIPTION 36 7.92e-01 0.025400 9.02e-01
G PROTEIN BETA GAMMA SIGNALLING 31 8.13e-01 0.024600 9.16e-01
IRAK1 RECRUITS IKK COMPLEX 14 8.74e-01 0.024400 9.39e-01
MET ACTIVATES PTK2 SIGNALING 29 8.21e-01 0.024300 9.19e-01
DEGRADATION OF AXIN 53 7.61e-01 0.024200 8.87e-01
MRNA CAPPING 29 8.25e-01 0.023800 9.21e-01
RHO GTPASES ACTIVATE PAKS 21 8.50e-01 -0.023800 9.35e-01
NONHOMOLOGOUS END JOINING NHEJ 46 7.81e-01 -0.023700 8.94e-01
DNA DOUBLE STRAND BREAK REPAIR 140 6.41e-01 -0.022800 8.03e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 7.03e-01 -0.022500 8.46e-01
AGGREPHAGY 34 8.25e-01 0.021900 9.21e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 7.79e-01 0.021900 8.94e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 5.68e-01 -0.021600 7.53e-01
INTERLEUKIN 12 FAMILY SIGNALING 43 8.08e-01 0.021400 9.14e-01
ORC1 REMOVAL FROM CHROMATIN 67 7.62e-01 0.021400 8.87e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 7.44e-01 0.021400 8.79e-01
SENSORY PROCESSING OF SOUND 62 7.73e-01 -0.021200 8.91e-01
DEVELOPMENTAL BIOLOGY 831 3.19e-01 -0.020500 5.57e-01
TRANSCRIPTIONAL REGULATION BY MECP2 59 7.91e-01 -0.020000 9.02e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 8.78e-01 0.019800 9.42e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.27e-01 0.019800 9.21e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 8.15e-01 0.019800 9.17e-01
INTERLEUKIN 12 SIGNALING 37 8.37e-01 0.019600 9.27e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 8.36e-01 -0.019400 9.27e-01
DAP12 INTERACTIONS 30 8.54e-01 -0.019400 9.35e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 8.81e-01 0.019400 9.43e-01
REGULATION OF BETA CELL DEVELOPMENT 30 8.56e-01 -0.019100 9.36e-01
ANTIGEN PROCESSING CROSS PRESENTATION 97 7.47e-01 -0.018900 8.79e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 20 8.85e-01 -0.018600 9.47e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 8.88e-01 -0.018600 9.49e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 7.86e-01 0.018200 8.99e-01
THE NLRP3 INFLAMMASOME 15 9.04e-01 0.017900 9.61e-01
DEGRADATION OF DVL 55 8.20e-01 -0.017800 9.19e-01
FRS MEDIATED FGFR1 SIGNALING 18 8.97e-01 -0.017600 9.56e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 7.54e-01 -0.017500 8.83e-01
SIGNALING BY CSF3 G CSF 29 8.71e-01 0.017500 9.39e-01
FLT3 SIGNALING IN DISEASE 28 8.74e-01 0.017300 9.39e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 9.21e-01 -0.017200 9.72e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 68 8.10e-01 -0.016900 9.14e-01
RA BIOSYNTHESIS PATHWAY 13 9.17e-01 -0.016700 9.69e-01
SIGNALING BY ERYTHROPOIETIN 24 8.88e-01 0.016500 9.49e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 9.04e-01 -0.016400 9.61e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 8.13e-01 0.016300 9.16e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 9.26e-01 0.016300 9.74e-01
EXTRACELLULAR MATRIX ORGANIZATION 251 6.62e-01 -0.016100 8.18e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 8.07e-01 0.016000 9.14e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 8.59e-01 -0.015800 9.36e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 8.45e-01 -0.015500 9.31e-01
HIV TRANSCRIPTION INITIATION 45 8.59e-01 0.015400 9.36e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 8.38e-01 0.015000 9.27e-01
SEMAPHORIN INTERACTIONS 64 8.39e-01 -0.014700 9.27e-01
TRANSCRIPTIONAL REGULATION BY TP53 343 6.41e-01 0.014700 8.03e-01
DAP12 SIGNALING 24 9.02e-01 -0.014600 9.60e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 8.66e-01 -0.014400 9.39e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 8.96e-01 0.014300 9.56e-01
G2 M CHECKPOINTS 136 7.75e-01 -0.014200 8.92e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 9.08e-01 -0.014200 9.62e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 9.20e-01 -0.014000 9.72e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 8.66e-01 -0.013700 9.39e-01
SIGNALING BY FGFR 75 8.44e-01 0.013200 9.30e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 9.39e-01 0.012700 9.76e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 9.11e-01 0.012600 9.65e-01
ENDOGENOUS STEROLS 20 9.24e-01 0.012400 9.73e-01
MAPK6 MAPK4 SIGNALING 83 8.52e-01 -0.011800 9.35e-01
JOSEPHIN DOMAIN DUBS 11 9.46e-01 0.011800 9.76e-01
PI 3K CASCADE FGFR4 13 9.43e-01 0.011600 9.76e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 9.47e-01 -0.011500 9.76e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 9.27e-01 0.011000 9.74e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.08e-01 -0.011000 9.62e-01
DNA REPAIR 295 7.56e-01 -0.010500 8.85e-01
N GLYCAN ANTENNAE ELONGATION 15 9.45e-01 0.010300 9.76e-01
HEME SIGNALING 46 9.06e-01 -0.010100 9.61e-01
SIGNALING BY NOTCH4 83 8.75e-01 0.010000 9.39e-01
ESR MEDIATED SIGNALING 171 8.23e-01 -0.009920 9.21e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 9.41e-01 0.009840 9.76e-01
SIGNALING BY NODAL 15 9.50e-01 0.009400 9.76e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 9.45e-01 0.009190 9.76e-01
NERVOUS SYSTEM DEVELOPMENT 553 7.15e-01 -0.009120 8.52e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 9.44e-01 0.008920 9.76e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 9.42e-01 0.008840 9.76e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 9.35e-01 -0.008800 9.76e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 606 7.18e-01 -0.008630 8.55e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.36e-01 -0.008580 9.76e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 9.61e-01 -0.008560 9.81e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 9.49e-01 0.008510 9.76e-01
PERK REGULATES GENE EXPRESSION 28 9.38e-01 -0.008460 9.76e-01
FANCONI ANEMIA PATHWAY 36 9.33e-01 0.008150 9.76e-01
CELLULAR SENESCENCE 144 8.68e-01 0.008010 9.39e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 9.30e-01 0.007950 9.76e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 8.97e-01 0.007730 9.56e-01
METALLOPROTEASE DUBS 26 9.48e-01 -0.007320 9.76e-01
DNA DAMAGE BYPASS 47 9.31e-01 -0.007310 9.76e-01
STABILIZATION OF P53 54 9.26e-01 -0.007300 9.74e-01
POLO LIKE KINASE MEDIATED EVENTS 14 9.62e-01 -0.007280 9.81e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 179 8.67e-01 0.007250 9.39e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 9.47e-01 0.007000 9.76e-01
TELOMERE EXTENSION BY TELOMERASE 22 9.56e-01 -0.006870 9.79e-01
SURFACTANT METABOLISM 16 9.63e-01 0.006680 9.81e-01
SIGNALING BY NOTCH 192 8.74e-01 0.006650 9.39e-01
ANTIMICROBIAL PEPTIDES 16 9.64e-01 -0.006530 9.81e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 9.55e-01 -0.006400 9.79e-01
MITOCHONDRIAL BIOGENESIS 92 9.17e-01 0.006310 9.69e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 60 9.41e-01 -0.005520 9.76e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 9.60e-01 -0.005380 9.81e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 9.66e-01 -0.005070 9.81e-01
FOXO MEDIATED TRANSCRIPTION 57 9.48e-01 -0.005020 9.76e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 9.43e-01 -0.004800 9.76e-01
SYNDECAN INTERACTIONS 27 9.66e-01 0.004780 9.81e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 9.52e-01 -0.004730 9.78e-01
SIGNALING BY FGFR2 63 9.50e-01 0.004610 9.76e-01
CELLULAR RESPONSE TO HYPOXIA 72 9.48e-01 -0.004470 9.76e-01
DUAL INCISION IN GG NER 41 9.61e-01 -0.004460 9.81e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 9.68e-01 -0.004380 9.81e-01
NUCLEOTIDE EXCISION REPAIR 110 9.42e-01 0.004030 9.76e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 9.73e-01 0.004010 9.85e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 9.80e-01 0.003930 9.87e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 9.78e-01 -0.003730 9.87e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.53e-01 -0.003690 9.78e-01
OTHER INTERLEUKIN SIGNALING 20 9.79e-01 0.003480 9.87e-01
CHAPERONE MEDIATED AUTOPHAGY 20 9.79e-01 -0.003370 9.87e-01
TRANSCRIPTION OF THE HIV GENOME 67 9.62e-01 0.003370 9.81e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 9.86e-01 -0.003100 9.92e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 9.69e-01 0.002900 9.82e-01
PEPTIDE LIGAND BINDING RECEPTORS 112 9.61e-01 0.002650 9.81e-01
SIGNALING BY FGFR IN DISEASE 57 9.78e-01 -0.002100 9.87e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 9.91e-01 0.001560 9.95e-01
SIGNALING BY PDGF 56 9.86e-01 -0.001310 9.92e-01
HATS ACETYLATE HISTONES 96 9.83e-01 0.001290 9.89e-01
RNA POLYMERASE II TRANSCRIPTION 1098 9.65e-01 0.000793 9.81e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 9.93e-01 0.000411 9.97e-01
AURKA ACTIVATION BY TPX2 71 9.96e-01 0.000382 9.98e-01
ARACHIDONIC ACID METABOLISM 39 9.98e-01 0.000256 9.98e-01
HS GAG DEGRADATION 20 9.98e-01 -0.000244 9.98e-01
MUSCLE CONTRACTION 160 9.98e-01 -0.000119 9.98e-01


Detailed Gene set reports



CITRIC ACID CYCLE TCA CYCLE
set CITRIC ACID CYCLE TCA CYCLE
setSize 22
pANOVA 4.62e-05
s.dist 0.502
p.adjustANOVA 0.00121


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fh1 9133
Idh3a 8827
Dld 8678
Suclg2 8614
Aco2 8602
Idh2 8064
Sucla2 7808
Idh3b 7713
Sdha 6929
Dlst 6268
Me2 6250
Cs 5428
Sdhd 5006
Idh3g 5003
Ogdh 4677
Mdh2 2254
Sdhb 1651
Nnt 1615
Sdhc 1352
Suclg1 983

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fh1 9133
Idh3a 8827
Dld 8678
Suclg2 8614
Aco2 8602
Idh2 8064
Sucla2 7808
Idh3b 7713
Sdha 6929
Dlst 6268
Me2 6250
Cs 5428
Sdhd 5006
Idh3g 5003
Ogdh 4677
Mdh2 2254
Sdhb 1651
Nnt 1615
Sdhc 1352
Suclg1 983
Me3 -991
Fahd1 -4038


OLFACTORY SIGNALING PATHWAY
set OLFACTORY SIGNALING PATHWAY
setSize 37
pANOVA 1.49e-07
s.dist -0.499
p.adjustANOVA 1.1e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Olfr981 -8240
Olfr1310 -8239
Olfr354 -8223
Olfr1192-ps1 -8078
Olfr90 -7979
Olfr635 -7972
Olfr1309 -7848
Olfr986 -7573
Gng13 -7564
Olfr1385 -7543
Olfr804 -7480
Olfr161 -7381
Olfr365 -7364
Olfr558 -7280
Olfr796 -7248
Olfr63 -7104
Olfr1507 -6907
Olfr78 -6878
Olfr1564 -6552
Olfr2 -5836

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Olfr981 -8240
Olfr1310 -8239
Olfr354 -8223
Olfr1192-ps1 -8078
Olfr90 -7979
Olfr635 -7972
Olfr1309 -7848
Olfr986 -7573
Gng13 -7564
Olfr1385 -7543
Olfr804 -7480
Olfr161 -7381
Olfr365 -7364
Olfr558 -7280
Olfr796 -7248
Olfr63 -7104
Olfr1507 -6907
Olfr78 -6878
Olfr1564 -6552
Olfr2 -5836
Olfr735 -5808
Olfr31 -5449
Rtp4 -5042
Olfr147 -3050
Olfr95 -2967
Olfr552 -1383
Olfr137 -1241
Reep4 -272
Reep6 -269
Olfr287 474
Olfr648 1881
Reep2 3140
Gnal 4034
Gnb1 4897
Reep3 5316
Reep5 6600
Reep1 7064


SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
set SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
setSize 11
pANOVA 0.0042
s.dist 0.499
p.adjustANOVA 0.0329


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fig4 9255
Pik3c3 6958
Pik3c2a 6872
Pik3r4 6219
Mtmr2 6066
Vac14 5947
Mtm1 5798
Mtmr7 5165
Mtmr4 4826
Mtmr9 -1104
Pikfyve -1364

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fig4 9255
Pik3c3 6958
Pik3c2a 6872
Pik3r4 6219
Mtmr2 6066
Vac14 5947
Mtm1 5798
Mtmr7 5165
Mtmr4 4826
Mtmr9 -1104
Pikfyve -1364


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
set ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize 12
pANOVA 0.00304
s.dist 0.494
p.adjustANOVA 0.0258


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hsd17b4 8978
Elovl2 8860
Acox1 8768
Fads2 8555
Acsl1 7586
Fads1 7236
Elovl1 6341
Elovl5 6155
Scp2 4298
Acaa1a -518
Acot8 -2873
Abcd1 -4262

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsd17b4 8978
Elovl2 8860
Acox1 8768
Fads2 8555
Acsl1 7586
Fads1 7236
Elovl1 6341
Elovl5 6155
Scp2 4298
Acaa1a -518
Acot8 -2873
Abcd1 -4262


PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
set PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
setSize 12
pANOVA 0.00361
s.dist 0.485
p.adjustANOVA 0.0296


Top enriched genes
Top 20 genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6792
Impdh2 6201
Ppat 5024
Impdh1 3878
Gmps 3091
Lhpp 2724
Adssl1 2690
Pfas -4914

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6792
Impdh2 6201
Ppat 5024
Impdh1 3878
Gmps 3091
Lhpp 2724
Adssl1 2690
Pfas -4914


CALNEXIN CALRETICULIN CYCLE
set CALNEXIN CALRETICULIN CYCLE
setSize 26
pANOVA 2.34e-05
s.dist 0.479
p.adjustANOVA 0.000788


Top enriched genes
Top 20 genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Pdia3 8431
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6524
Ubc 5934
Edem1 5391
Calr 5200
Sel1l 5082
Rnf103 5035
Trim13 4181
Uggt2 3863
Rnf185 2137

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Pdia3 8431
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6524
Ubc 5934
Edem1 5391
Calr 5200
Sel1l 5082
Rnf103 5035
Trim13 4181
Uggt2 3863
Rnf185 2137
Canx 1754
Rnf5 1026
Prkcsh 96
Rps27a -2074
Ubb -2117
Uba52 -7861


ER QUALITY CONTROL COMPARTMENT ERQC
set ER QUALITY CONTROL COMPARTMENT ERQC
setSize 21
pANOVA 0.000158
s.dist 0.476
p.adjustANOVA 0.00298


Top enriched genes
Top 20 genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Man1b1 8695
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6524
Ubc 5934
Edem1 5391
Sel1l 5082
Rnf103 5035
Trim13 4181
Uggt2 3863
Rnf185 2137
Rnf5 1026
Rps27a -2074
Ubb -2117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Man1b1 8695
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6524
Ubc 5934
Edem1 5391
Sel1l 5082
Rnf103 5035
Trim13 4181
Uggt2 3863
Rnf185 2137
Rnf5 1026
Rps27a -2074
Ubb -2117
Uba52 -7861


RHOBTB3 ATPASE CYCLE
set RHOBTB3 ATPASE CYCLE
setSize 10
pANOVA 0.00935
s.dist 0.475
p.adjustANOVA 0.0584


Top enriched genes
Top 20 genes
GeneID Gene Rank
Htr7 9100
Cul3 8203
Lrrc41 7885
Plin3 6741
Rhobtb3 6731
Hgs 5863
Rab9b 4401
Vhl 2585
Rab9 -1263
Ccne1 -2678

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Htr7 9100
Cul3 8203
Lrrc41 7885
Plin3 6741
Rhobtb3 6731
Hgs 5863
Rab9b 4401
Vhl 2585
Rab9 -1263
Ccne1 -2678


BRANCHED CHAIN AMINO ACID CATABOLISM
set BRANCHED CHAIN AMINO ACID CATABOLISM
setSize 21
pANOVA 0.000192
s.dist 0.47
p.adjustANOVA 0.00337


Top enriched genes
Top 20 genes
GeneID Gene Rank
Aldh6a1 9266
Ivd 8736
Dld 8678
Echs1 8363
Acat1 8250
Hibadh 8043
Dbt 7239
Acad8 7102
Slc25a44 6766
Acadsb 6762
Bcat2 6690
Bckdhb 6649
Mccc2 5900
Mccc1 5346
Hsd17b10 3225
Bcat1 2403
Hibch -65
Bckdk -1050
Bckdha -1161
Auh -1852

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aldh6a1 9266
Ivd 8736
Dld 8678
Echs1 8363
Acat1 8250
Hibadh 8043
Dbt 7239
Acad8 7102
Slc25a44 6766
Acadsb 6762
Bcat2 6690
Bckdhb 6649
Mccc2 5900
Mccc1 5346
Hsd17b10 3225
Bcat1 2403
Hibch -65
Bckdk -1050
Bckdha -1161
Auh -1852
Ppm1k -6290


SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
set SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
setSize 16
pANOVA 0.00114
s.dist 0.47
p.adjustANOVA 0.0127


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fig4 9255
Mtmr10 8910
Inpp5f 7618
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6872
Pik3r4 6219
Mtmr2 6066
Vac14 5947
Mtm1 5798
Inpp4b 5663
Mtmr4 4826
Mtmr12 2425
Pikfyve -1364
Pi4k2b -2262
Inpp4a -4799

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fig4 9255
Mtmr10 8910
Inpp5f 7618
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6872
Pik3r4 6219
Mtmr2 6066
Vac14 5947
Mtm1 5798
Inpp4b 5663
Mtmr4 4826
Mtmr12 2425
Pikfyve -1364
Pi4k2b -2262
Inpp4a -4799


INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
set INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
setSize 13
pANOVA 0.00398
s.dist 0.461
p.adjustANOVA 0.0317


Top enriched genes
Top 20 genes
GeneID Gene Rank
Prim2 8549
E2f1 8530
Tfdp1 8407
Prim1 7456
Rb1 7232
Pola2 7148
Pola1 5714
Ppp2ca 5173
Ppp2r1a 4645
Ppp2r1b 4000
Tfdp2 951
Ppp2cb -1874
Ppp2r3d -5632

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prim2 8549
E2f1 8530
Tfdp1 8407
Prim1 7456
Rb1 7232
Pola2 7148
Pola1 5714
Ppp2ca 5173
Ppp2r1a 4645
Ppp2r1b 4000
Tfdp2 951
Ppp2cb -1874
Ppp2r3d -5632


ASPARTATE AND ASPARAGINE METABOLISM
set ASPARTATE AND ASPARAGINE METABOLISM
setSize 10
pANOVA 0.0124
s.dist 0.456
p.adjustANOVA 0.0712


Top enriched genes
Top 20 genes
GeneID Gene Rank
Folh1 9329
Asns 7860
Slc25a12 7310
Aspa 6691
Got1 6415
Got2 5977
Slc25a13 2809
Aspg 1023
Nat8l -149
Naalad2 -1306

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Folh1 9329
Asns 7860
Slc25a12 7310
Aspa 6691
Got1 6415
Got2 5977
Slc25a13 2809
Aspg 1023
Nat8l -149
Naalad2 -1306


MET ACTIVATES RAP1 AND RAC1
set MET ACTIVATES RAP1 AND RAC1
setSize 10
pANOVA 0.0132
s.dist 0.452
p.adjustANOVA 0.0732


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rac1 8591
Rap1b 7791
Crkl 7397
Crk 6794
Gab1 6016
Rap1a 5150
Met 3938
Rapgef1 3787
Grb2 -1887
Dock7 -1971

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rac1 8591
Rap1b 7791
Crkl 7397
Crk 6794
Gab1 6016
Rap1a 5150
Met 3938
Rapgef1 3787
Grb2 -1887
Dock7 -1971


BBSOME MEDIATED CARGO TARGETING TO CILIUM
set BBSOME MEDIATED CARGO TARGETING TO CILIUM
setSize 23
pANOVA 0.000174
s.dist 0.452
p.adjustANOVA 0.0032


Top enriched genes
Top 20 genes
GeneID Gene Rank
Lztfl1 8991
Tcp1 8148
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6619
Bbs7 6426
Cct5 6047
Ttc8 5748
Bbs10 5623
Bbs4 5542
Cct4 5522
Smo 5124
Cct2 3790
Sstr3 3328
Cct8 3157
Bbs2 307
Bbs12 -115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lztfl1 8991
Tcp1 8148
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6619
Bbs7 6426
Cct5 6047
Ttc8 5748
Bbs10 5623
Bbs4 5542
Cct4 5522
Smo 5124
Cct2 3790
Sstr3 3328
Cct8 3157
Bbs2 307
Bbs12 -115
Bbs9 -196
Bbip1 -690
Bbs5 -4885


RETROGRADE NEUROTROPHIN SIGNALLING
set RETROGRADE NEUROTROPHIN SIGNALLING
setSize 14
pANOVA 0.00481
s.dist 0.435
p.adjustANOVA 0.0363


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dnm2 9347
Ap2b1 7444
Ap2a2 7134
Ntrk1 6899
Cltc 6292
Dnm3 6030
Ngf 5437
Dnm1 4329
Ap2m1 4125
Ap2a1 3886
Sh3gl2 3301
Dnal4 1865
Clta -54
Ap2s1 -4316

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dnm2 9347
Ap2b1 7444
Ap2a2 7134
Ntrk1 6899
Cltc 6292
Dnm3 6030
Ngf 5437
Dnm1 4329
Ap2m1 4125
Ap2a1 3886
Sh3gl2 3301
Dnal4 1865
Clta -54
Ap2s1 -4316


CAMK IV MEDIATED PHOSPHORYLATION OF CREB
set CAMK IV MEDIATED PHOSPHORYLATION OF CREB
setSize 10
pANOVA 0.0187
s.dist 0.429
p.adjustANOVA 0.0899


Top enriched genes
Top 20 genes
GeneID Gene Rank
Kpna2 9344
Creb1 8392
Camk2a 7843
Camkk1 6097
Camk2g 5545
Camk4 5132
Camk2d 3325
Camk2b 944
Camkk2 43
Calm1 -3081

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kpna2 9344
Creb1 8392
Camk2a 7843
Camkk1 6097
Camk2g 5545
Camk4 5132
Camk2d 3325
Camk2b 944
Camkk2 43
Calm1 -3081


SCAVENGING OF HEME FROM PLASMA
set SCAVENGING OF HEME FROM PLASMA
setSize 11
pANOVA 0.0144
s.dist -0.426
p.adjustANOVA 0.0758


Top enriched genes
Top 20 genes
GeneID Gene Rank
Apol7e -6912
Hp -6781
Apol9a -6647
Hbb-bt -5510
Hba-a1 -5355
Jchain -5036
Hba-a2 -4255
Apoa1 -2842
Apol8 1405
Lrp1 2286
Cd163 4596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Apol7e -6912
Hp -6781
Apol9a -6647
Hbb-bt -5510
Hba-a1 -5355
Jchain -5036
Hba-a2 -4255
Apoa1 -2842
Apol8 1405
Lrp1 2286
Cd163 4596


SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
set SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize 20
pANOVA 0.000982
s.dist 0.426
p.adjustANOVA 0.0114


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acsbg1 9232
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6745
Elovl4 6613
Elovl1 6341
Elovl5 6155
Acsf3 4046
Acsl5 3754
Elovl6 3697
Hacd3 1139
Slc27a3 -2396
Tecr -4049
Hacd1 -5407
Elovl7 -5885

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acsbg1 9232
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6745
Elovl4 6613
Elovl1 6341
Elovl5 6155
Acsf3 4046
Acsl5 3754
Elovl6 3697
Hacd3 1139
Slc27a3 -2396
Tecr -4049
Hacd1 -5407
Elovl7 -5885


N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
set N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
setSize 35
pANOVA 1.56e-05
s.dist 0.422
p.adjustANOVA 0.000597


Top enriched genes
Top 20 genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Derl1 8460
Pdia3 8431
Mlec 8086
Syvn1 8025
Ngly1 8020
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6524
Ubc 5934
Edem1 5391
Calr 5200
Sel1l 5082
Rnf103 5035

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Derl1 8460
Pdia3 8431
Mlec 8086
Syvn1 8025
Ngly1 8020
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6524
Ubc 5934
Edem1 5391
Calr 5200
Sel1l 5082
Rnf103 5035
Rad23b 4888
Vcp 4495
Trim13 4181
Uggt2 3863
Rnf185 2137
Canx 1754
Rnf5 1026
Engase 898
Prkcsh 96
Rps27a -2074
Ubb -2117
Ubxn1 -2536
Mogs -2862
Psmc1 -4018
Uba52 -7861


THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
set THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
setSize 27
pANOVA 0.000188
s.dist 0.415
p.adjustANOVA 0.00335


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ap1m1 9091
Elmo1 8839
Pak2 8711
Fyn 8650
Rac1 8591
Ap1b1 7973
H2-Q2 7969
Atp6v1h 7606
Ap2b1 7444
Ap2a2 7134
Hck 6759
Dock2 6605
Ap1m2 5629
Arf1 4883
Pacs1 4526
Ap2m1 4125
Ap2a1 3886
Ap1g1 3872
Ap1s1 3751
Ap1s2 2200

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ap1m1 9091
Elmo1 8839
Pak2 8711
Fyn 8650
Rac1 8591
Ap1b1 7973
H2-Q2 7969
Atp6v1h 7606
Ap2b1 7444
Ap2a2 7134
Hck 6759
Dock2 6605
Ap1m2 5629
Arf1 4883
Pacs1 4526
Ap2m1 4125
Ap2a1 3886
Ap1g1 3872
Ap1s1 3751
Ap1s2 2200
Lck 1854
H2-Q7 40
B2m -114
H2-D1 -2017
H2-Q10 -2383
Ap2s1 -4316
Ap1s3 -7100


POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
set POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
setSize 26
pANOVA 0.000311
s.dist 0.409
p.adjustANOVA 0.00458


Top enriched genes
Top 20 genes
GeneID Gene Rank
Nup54 8879
Ndc1 8176
Rcc1 7498
Nup160 7385
Tnpo1 7074
Nup107 6352
Nup205 6184
Pom121 5824
Nup133 5736
Nup37 5698
Sec13 5692
Kpnb1 5615
Seh1l 4721
Nup85 4518
Ahctf1 4492
Ube2i 4396
Nup188 3207
Sumo1 2914
Ran 2867
Rangap1 2277

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nup54 8879
Ndc1 8176
Rcc1 7498
Nup160 7385
Tnpo1 7074
Nup107 6352
Nup205 6184
Pom121 5824
Nup133 5736
Nup37 5698
Sec13 5692
Kpnb1 5615
Seh1l 4721
Nup85 4518
Ahctf1 4492
Ube2i 4396
Nup188 3207
Sumo1 2914
Ran 2867
Rangap1 2277
Nup98 2187
Nup35 1612
Nup43 1248
Nup93 -1283
Nup62 -1907
Nup155 -2924


CARNITINE METABOLISM
set CARNITINE METABOLISM
setSize 14
pANOVA 0.00833
s.dist 0.407
p.adjustANOVA 0.0532


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cpt1a 8349
Prkag2 7700
Cpt2 7512
Rxra 7494
Prkaa2 7318
Cpt1b 6931
Mid1ip1 6515
Acacb 4804
Acaca 3654
Ppard 2873
Slc25a20 2361
Thrsp 18
Prkab2 -699
Slc22a5 -6565

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cpt1a 8349
Prkag2 7700
Cpt2 7512
Rxra 7494
Prkaa2 7318
Cpt1b 6931
Mid1ip1 6515
Acacb 4804
Acaca 3654
Ppard 2873
Slc25a20 2361
Thrsp 18
Prkab2 -699
Slc22a5 -6565


ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
set ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
setSize 10
pANOVA 0.0259
s.dist 0.407
p.adjustANOVA 0.111


Top enriched genes
Top 20 genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6849
Chrna5 6011
Chrnb4 5459
Chrnb2 4198
Chrnb3 2109
Chrna2 1055
Chrna7 1
Chrna1 -542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6849
Chrna5 6011
Chrnb4 5459
Chrnb2 4198
Chrnb3 2109
Chrna2 1055
Chrna7 1
Chrna1 -542


HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
set HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
setSize 10
pANOVA 0.0259
s.dist 0.407
p.adjustANOVA 0.111


Top enriched genes
Top 20 genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6849
Chrna5 6011
Chrnb4 5459
Chrnb2 4198
Chrnb3 2109
Chrna2 1055
Chrna7 1
Chrna1 -542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6849
Chrna5 6011
Chrnb4 5459
Chrnb2 4198
Chrnb3 2109
Chrna2 1055
Chrna7 1
Chrna1 -542


PROLONGED ERK ACTIVATION EVENTS
set PROLONGED ERK ACTIVATION EVENTS
setSize 14
pANOVA 0.00937
s.dist 0.401
p.adjustANOVA 0.0584


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mapk1 8052
Map2k1 7865
Crkl 7397
Ntrk1 6899
Crk 6794
Ngf 5437
Mapk3 5190
Rap1a 5150
Frs2 3803
Rapgef1 3787
Ywhab 3620
Braf 1446
Kidins220 -3048
Map2k2 -4888

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk1 8052
Map2k1 7865
Crkl 7397
Ntrk1 6899
Crk 6794
Ngf 5437
Mapk3 5190
Rap1a 5150
Frs2 3803
Rapgef1 3787
Ywhab 3620
Braf 1446
Kidins220 -3048
Map2k2 -4888


FERTILIZATION
set FERTILIZATION
setSize 13
pANOVA 0.0129
s.dist -0.398
p.adjustANOVA 0.0724


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acr -7108
Ovgp1 -6727
Catsperd -6272
Adam21 -5803
Catsper3 -5160
Catsperg1 -4967
Hvcn1 -3779
B4galt1 -2668
Izumo4 -2142
Catsper2 -1859
Kcnu1 -1466
Cd9 3078
Catsperg2 6687

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acr -7108
Ovgp1 -6727
Catsperd -6272
Adam21 -5803
Catsper3 -5160
Catsperg1 -4967
Hvcn1 -3779
B4galt1 -2668
Izumo4 -2142
Catsper2 -1859
Kcnu1 -1466
Cd9 3078
Catsperg2 6687


SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
set SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
setSize 15
pANOVA 0.00762
s.dist 0.398
p.adjustANOVA 0.0504


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fig4 9255
Sacm1l 7742
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6872
Pik3r4 6219
Ocrl 6106
Vac14 5947
Pi4kb 5177
Arf1 4883
Pi4ka 74
Inpp5e 44
Pikfyve -1364
Arf3 -1728
Pi4k2b -2262

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fig4 9255
Sacm1l 7742
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6872
Pik3r4 6219
Ocrl 6106
Vac14 5947
Pi4kb 5177
Arf1 4883
Pi4ka 74
Inpp5e 44
Pikfyve -1364
Arf3 -1728
Pi4k2b -2262


GLYCOSPHINGOLIPID METABOLISM
set GLYCOSPHINGOLIPID METABOLISM
setSize 38
pANOVA 2.62e-05
s.dist 0.394
p.adjustANOVA 0.000813


Top enriched genes
Top 20 genes
GeneID Gene Rank
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
B4galnt1 7463
Gba2 7449
Ugt8a 6367
Psap 6329
Ugcg 6319
Gltp 6024
Neu1 5422
Cerk 5236
Neu2 5148
Cptp 5088
Gm2a 5038

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
B4galnt1 7463
Gba2 7449
Ugt8a 6367
Psap 6329
Ugcg 6319
Gltp 6024
Neu1 5422
Cerk 5236
Neu2 5148
Cptp 5088
Gm2a 5038
Hexb 4731
Glb1l 4484
Gba 4024
Arsg 3796
Arsk 3010
Smpd1 2487
Smpd3 2175
Glb1 1255
Esyt2 802
Sumf1 674
Sumf2 -146
Smpd2 -414
Hexa -484
Asah2 -759
Ctsa -3078
Arsj -3301
Smpd4 -3361
Esyt3 -7346


SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI
set SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI
setSize 18
pANOVA 0.00382
s.dist 0.394
p.adjustANOVA 0.0306


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pigw 9250
Pigf 8812
Pigv 8682
Piga 8636
Pigx 8506
Pigq 6607
Pign 6043
Pigg 5974
Pigc 5805
Pigm 5618
Pigz 4580
Pigo 2828
Pigl 1733
Dpm2 768
Pigh -1611
Pigp -1969
Pigyl -2301
Pigb -5202

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pigw 9250
Pigf 8812
Pigv 8682
Piga 8636
Pigx 8506
Pigq 6607
Pign 6043
Pigg 5974
Pigc 5805
Pigm 5618
Pigz 4580
Pigo 2828
Pigl 1733
Dpm2 768
Pigh -1611
Pigp -1969
Pigyl -2301
Pigb -5202


SPHINGOLIPID METABOLISM
set SPHINGOLIPID METABOLISM
setSize 80
pANOVA 1.26e-09
s.dist 0.393
p.adjustANOVA 1.86e-07


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ormdl1 9234
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Sptlc1 8849
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
B4galnt1 7463
Gba2 7449
Degs2 7360
Sptssa 7264

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ormdl1 9234
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Sptlc1 8849
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
B4galnt1 7463
Gba2 7449
Degs2 7360
Sptssa 7264
Osbp 7103
Prkd1 7026
Plpp1 6838
Aldh3a2 6665
Ugt8a 6367
Psap 6329
Ugcg 6319
Prkd3 6317
Sgms2 6028
Cert1 6025
Gltp 6024
Cers5 5944
Cers1 5879
Sgpp1 5778
Csnk1g2 5734
Sgpp2 5584
Neu1 5422
Cerk 5236
Neu2 5148
Sgpl1 5131
Cptp 5088
Gm2a 5038
Ormdl3 4975
Sphk1 4791
Hexb 4731
Sptlc2 4654
Glb1l 4484
Cers6 4402
Sptlc3 4201
Vapb 4059
Gba 4024
Arsg 3796
Ppm1l 3791
Sptssb 3147
Cers2 3115
Arsk 3010
Prkd2 2921
Smpd1 2487
Spns2 2462
Smpd3 2175
Plpp2 1348
Glb1 1255
Esyt2 802
Sumf1 674
Sumf2 -146
Smpd2 -414
Hexa -484
Asah2 -759
Acer2 -1958
Sphk2 -2023
Vapa -2541
Kdsr -2816
Aldh3b1 -2907
Ctsa -3078
Acer3 -3259
Arsj -3301
Smpd4 -3361
Samd8 -5801
Cers4 -7036
Esyt3 -7346


DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS
set DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS
setSize 11
pANOVA 0.0242
s.dist -0.393
p.adjustANOVA 0.107


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gp1ba -8198
Gp1bb -8002
Ggcx -6810
Tpst1 -5531
Serping1 -5478
Klkb1 -4300
F12 -2629
F8 -2134
Gp5 -310
Vwf 3865
Tpst2 7745

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gp1ba -8198
Gp1bb -8002
Ggcx -6810
Tpst1 -5531
Serping1 -5478
Klkb1 -4300
F12 -2629
F8 -2134
Gp5 -310
Vwf 3865
Tpst2 7745


SPHINGOLIPID DE NOVO BIOSYNTHESIS
set SPHINGOLIPID DE NOVO BIOSYNTHESIS
setSize 42
pANOVA 1.24e-05
s.dist 0.39
p.adjustANOVA 0.000517


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ormdl1 9234
Sptlc1 8849
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
Degs2 7360
Sptssa 7264
Osbp 7103
Prkd1 7026
Plpp1 6838
Aldh3a2 6665
Prkd3 6317
Sgms2 6028
Cert1 6025
Cers5 5944
Cers1 5879
Sgpp1 5778
Csnk1g2 5734

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ormdl1 9234
Sptlc1 8849
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
Degs2 7360
Sptssa 7264
Osbp 7103
Prkd1 7026
Plpp1 6838
Aldh3a2 6665
Prkd3 6317
Sgms2 6028
Cert1 6025
Cers5 5944
Cers1 5879
Sgpp1 5778
Csnk1g2 5734
Sgpp2 5584
Sgpl1 5131
Ormdl3 4975
Sphk1 4791
Sptlc2 4654
Cers6 4402
Sptlc3 4201
Vapb 4059
Ppm1l 3791
Sptssb 3147
Cers2 3115
Prkd2 2921
Spns2 2462
Plpp2 1348
Acer2 -1958
Sphk2 -2023
Vapa -2541
Kdsr -2816
Aldh3b1 -2907
Acer3 -3259
Samd8 -5801
Cers4 -7036


NUCLEOBASE BIOSYNTHESIS
set NUCLEOBASE BIOSYNTHESIS
setSize 15
pANOVA 0.01
s.dist 0.384
p.adjustANOVA 0.0609


Top enriched genes
Top 20 genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6792
Impdh2 6201
Ppat 5024
Umps 4179
Impdh1 3878
Gmps 3091
Lhpp 2724
Adssl1 2690
Dhodh 140
Cad -3154
Pfas -4914

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6792
Impdh2 6201
Ppat 5024
Umps 4179
Impdh1 3878
Gmps 3091
Lhpp 2724
Adssl1 2690
Dhodh 140
Cad -3154
Pfas -4914


COHESIN LOADING ONTO CHROMATIN
set COHESIN LOADING ONTO CHROMATIN
setSize 10
pANOVA 0.0373
s.dist 0.38
p.adjustANOVA 0.143


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rad21 8790
Stag2 8475
Pds5b 8032
Stag1 7069
Mau2 3631
Smc1a 3619
Pds5a 3450
Wapl 1483
Nipbl 1044
Smc3 -6351

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rad21 8790
Stag2 8475
Pds5b 8032
Stag1 7069
Mau2 3631
Smc1a 3619
Pds5a 3450
Wapl 1483
Nipbl 1044
Smc3 -6351


CTLA4 INHIBITORY SIGNALING
set CTLA4 INHIBITORY SIGNALING
setSize 20
pANOVA 0.00361
s.dist 0.376
p.adjustANOVA 0.0296


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptpn11 9296
Yes1 8654
Fyn 8650
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6725
Akt1 6663
Src 5682
Ppp2ca 5173
Ppp2r1a 4645
Akt3 4260
Ppp2r1b 4000
Lck 1854
Ppp2r5a 973
Cd86 362
Akt2 -508
Ppp2cb -1874
Lyn -2072
Cd80 -7689

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9296
Yes1 8654
Fyn 8650
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6725
Akt1 6663
Src 5682
Ppp2ca 5173
Ppp2r1a 4645
Akt3 4260
Ppp2r1b 4000
Lck 1854
Ppp2r5a 973
Cd86 362
Akt2 -508
Ppp2cb -1874
Lyn -2072
Cd80 -7689


ADENYLATE CYCLASE INHIBITORY PATHWAY
set ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize 13
pANOVA 0.0197
s.dist 0.373
p.adjustANOVA 0.0942


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gnai1 8119
Adcy8 7381
Gnai2 6928
Gnai3 6828
Adcy3 5594
Adcy5 5064
Gnal 4034
Adcy1 3298
Adcy2 3034
Adcy9 1921
Adcy7 1720
Adcy4 -1198
Adcy6 -2495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnai1 8119
Adcy8 7381
Gnai2 6928
Gnai3 6828
Adcy3 5594
Adcy5 5064
Gnal 4034
Adcy1 3298
Adcy2 3034
Adcy9 1921
Adcy7 1720
Adcy4 -1198
Adcy6 -2495


PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
set PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
setSize 15
pANOVA 0.0123
s.dist 0.373
p.adjustANOVA 0.0709


Top enriched genes
Top 20 genes
GeneID Gene Rank
Prim2 8549
Prim1 7456
Fen1 7372
Pola2 7148
Pcna 7097
Rpa1 6738
Pola1 5714
Pold2 2955
Pold3 2922
Rpa2 2327
Rpa3 2112
Pold1 1588
Dna2 1477
Pold4 -1607
Lig1 -3926

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prim2 8549
Prim1 7456
Fen1 7372
Pola2 7148
Pcna 7097
Rpa1 6738
Pola1 5714
Pold2 2955
Pold3 2922
Rpa2 2327
Rpa3 2112
Pold1 1588
Dna2 1477
Pold4 -1607
Lig1 -3926


RHOV GTPASE CYCLE
set RHOV GTPASE CYCLE
setSize 33
pANOVA 0.00024
s.dist 0.369
p.adjustANOVA 0.00388


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tpm4 9047
Git1 8959
Nck1 8828
Pak2 8711
Sh3rf1 7833
Wdr6 7605
Peak1 7447
Pak1 7413
Depdc1b 6978
Arhgap12 6937
Sptan1 6657
Cltc 6292
Wasl 6065
Sptbn1 5625
Txnl1 5488
Pik3r1 5026
Usp9x 4934
Epha2 4389
Arhgef7 4336
Cdc42 4312

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tpm4 9047
Git1 8959
Nck1 8828
Pak2 8711
Sh3rf1 7833
Wdr6 7605
Peak1 7447
Pak1 7413
Depdc1b 6978
Arhgap12 6937
Sptan1 6657
Cltc 6292
Wasl 6065
Sptbn1 5625
Txnl1 5488
Pik3r1 5026
Usp9x 4934
Epha2 4389
Arhgef7 4336
Cdc42 4312
Pak6 4041
Dlg5 2790
Tpm3 2381
Vangl1 1705
Rhov 544
Iqgap1 25
Ccp110 -28
Myo9a -37
Dst -927
Nck2 -2461
Git2 -3119
Zfp512b -5056
Cep97 -6538


PLATELET SENSITIZATION BY LDL
set PLATELET SENSITIZATION BY LDL
setSize 15
pANOVA 0.0138
s.dist 0.367
p.adjustANOVA 0.0744


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptpn11 9296
Pla2g4a 8646
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6725
Ppp2ca 5173
Ppp2r1a 4645
Ppp2r1b 4000
Mapk14 1966
Ppp2r5a 973
Lrp8 629
Ptpn6 -278
Ppp2cb -1874
Pecam1 -5641

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9296
Pla2g4a 8646
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6725
Ppp2ca 5173
Ppp2r1a 4645
Ppp2r1b 4000
Mapk14 1966
Ppp2r5a 973
Lrp8 629
Ptpn6 -278
Ppp2cb -1874
Pecam1 -5641


INSULIN PROCESSING
set INSULIN PROCESSING
setSize 24
pANOVA 0.00196
s.dist 0.365
p.adjustANOVA 0.0187


Top enriched genes
Top 20 genes
GeneID Gene Rank
Pcsk1 9031
Myrip 8778
Exoc5 8427
Ero1a 8332
Exoc7 8318
Exoc3 8205
Slc30a7 6963
Slc30a5 6864
Pcsk2 6801
Cpe 6310
Myo5a 5842
Kif5a 5705
Exoc1 4051
Kif5c 3836
Exoc4 2471
Exoc2 1209
Exoc8 1073
Ero1b 928
Exoc6 86
Rab27a -33

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pcsk1 9031
Myrip 8778
Exoc5 8427
Ero1a 8332
Exoc7 8318
Exoc3 8205
Slc30a7 6963
Slc30a5 6864
Pcsk2 6801
Cpe 6310
Myo5a 5842
Kif5a 5705
Exoc1 4051
Kif5c 3836
Exoc4 2471
Exoc2 1209
Exoc8 1073
Ero1b 928
Exoc6 86
Rab27a -33
Slc30a6 -372
Kif5b -2115
Stx1a -4260
Vamp2 -5513


LDL CLEARANCE
set LDL CLEARANCE
setSize 16
pANOVA 0.0115
s.dist 0.365
p.adjustANOVA 0.0671


Top enriched genes
Top 20 genes
GeneID Gene Rank
Soat1 8895
Lipa 7988
Nceh1 7697
Ap2b1 7444
Ap2a2 7134
Npc1 6396
Cltc 6292
Ldlrap1 4886
Ap2m1 4125
Ap2a1 3886
Lsr 3288
Clta -54
Npc2 -185
Ldlr -1175
Pcsk9 -1701
Ap2s1 -4316

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Soat1 8895
Lipa 7988
Nceh1 7697
Ap2b1 7444
Ap2a2 7134
Npc1 6396
Cltc 6292
Ldlrap1 4886
Ap2m1 4125
Ap2a1 3886
Lsr 3288
Clta -54
Npc2 -185
Ldlr -1175
Pcsk9 -1701
Ap2s1 -4316


FATTY ACYL COA BIOSYNTHESIS
set FATTY ACYL COA BIOSYNTHESIS
setSize 32
pANOVA 0.000406
s.dist 0.361
p.adjustANOVA 0.00569


Top enriched genes
Top 20 genes
GeneID Gene Rank
Acsbg1 9232
Ppt1 9171
Rpp14 9016
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6745
Elovl4 6613
Elovl1 6341
Elovl5 6155
Cbr4 6115
Scd2 4936
Acly 4807
Fasn 4779
Scd1 4691
Acsf3 4046

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acsbg1 9232
Ppt1 9171
Rpp14 9016
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6745
Elovl4 6613
Elovl1 6341
Elovl5 6155
Cbr4 6115
Scd2 4936
Acly 4807
Fasn 4779
Scd1 4691
Acsf3 4046
Acsl5 3754
Elovl6 3697
Acaca 3654
Hacd3 1139
Slc25a1 -653
Ppt2 -1276
Slc27a3 -2396
Tecr -4049
Morc2a -4956
Hacd1 -5407
Elovl7 -5885
H2-Ke6 -6652


SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
set SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
setSize 10
pANOVA 0.0492
s.dist 0.359
p.adjustANOVA 0.172


Top enriched genes
Top 20 genes
GeneID Gene Rank
Itpk1 9115
Nudt4 6775
Ppip5k2 6501
Ip6k1 6236
Ip6k3 5551
Ppip5k1 4294
Nudt11 4008
Nudt3 91
Ippk -2234
Nudt10 -2951

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itpk1 9115
Nudt4 6775
Ppip5k2 6501
Ip6k1 6236
Ip6k3 5551
Ppip5k1 4294
Nudt11 4008
Nudt3 91
Ippk -2234
Nudt10 -2951


RECEPTOR MEDIATED MITOPHAGY
set RECEPTOR MEDIATED MITOPHAGY
setSize 11
pANOVA 0.0405
s.dist 0.357
p.adjustANOVA 0.152


Top enriched genes
Top 20 genes
GeneID Gene Rank
Fundc1 8456
Atg5 7623
Atg12 7486
Pgam5 7265
Src 5682
Csnk2b 3206
Map1lc3b 2843
Ulk1 2744
Csnk2a1 -320
Csnk2a2 -490
Map1lc3a -3613

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fundc1 8456
Atg5 7623
Atg12 7486
Pgam5 7265
Src 5682
Csnk2b 3206
Map1lc3b 2843
Ulk1 2744
Csnk2a1 -320
Csnk2a2 -490
Map1lc3a -3613


REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
set REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize 15
pANOVA 0.017
s.dist 0.356
p.adjustANOVA 0.0857


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dld 8678
Pdk3 8528
Pdha1 8186
Pdp1 8170
Rxra 7494
Pdhx 6299
Pdk2 6009
Pdhb 5211
Pdpr 4575
Ppard 2873
Pdk4 2123
Dlat -619
Gstz1 -3091
Pdk1 -4311
Pdp2 -4496

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dld 8678
Pdk3 8528
Pdha1 8186
Pdp1 8170
Rxra 7494
Pdhx 6299
Pdk2 6009
Pdhb 5211
Pdpr 4575
Ppard 2873
Pdk4 2123
Dlat -619
Gstz1 -3091
Pdk1 -4311
Pdp2 -4496


INTRA GOLGI TRAFFIC
set INTRA GOLGI TRAFFIC
setSize 43
pANOVA 6.25e-05
s.dist 0.353
p.adjustANOVA 0.00144


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cog6 8754
Stx6 8556
Cux1 8537
Man1a 8443
Rab6a 8292
Cog1 7895
Snap29 7684
Cog4 7680
Vps45 7604
Vti1a 7461
Man2a1 6911
Cog2 6694
Napb 6586
Nsf 6551
Napa 6290
Napg 6086
Man1a2 5668
Ric1 5578
Rab30 5444
Golim4 5331

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cog6 8754
Stx6 8556
Cux1 8537
Man1a 8443
Rab6a 8292
Cog1 7895
Snap29 7684
Cog4 7680
Vps45 7604
Vti1a 7461
Man2a1 6911
Cog2 6694
Napb 6586
Nsf 6551
Napa 6290
Napg 6086
Man1a2 5668
Ric1 5578
Rab30 5444
Golim4 5331
Arf1 4883
Golga5 4560
Cog5 4249
Cyth3 4234
Cog3 3941
Gosr2 3129
Rab33b 2432
Stx5a 2306
Ykt6 2269
Man2a2 2237
Gosr1 2166
Rgp1 2001
Cog8 1609
Trip11 1608
Rab39 1407
Cyth1 448
Man1c1 264
Cog7 -2697
Stx16 -3187
Cyth2 -3564
Rab36 -4134
Bet1l -6287
Cyth4 -7805


RHOF GTPASE CYCLE
set RHOF GTPASE CYCLE
setSize 41
pANOVA 9.7e-05
s.dist 0.352
p.adjustANOVA 0.00204


Top enriched genes
Top 20 genes
GeneID Gene Rank
Farp1 9236
Snap23 9078
Tor1aip1 9062
Baiap2l1 8815
Esyt1 8442
Rhof 8157
Add3 8016
Sowahc 7962
Diaph1 7686
Cav1 7322
Depdc1b 6978
Arhgap32 6944
Arhgap12 6937
Tmpo 6445
Arhgap21 5837
Steap3 5653
Pik3r1 5026
Arhgap1 4998
Arhgap39 4867
Pik3r2 4624

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Farp1 9236
Snap23 9078
Tor1aip1 9062
Baiap2l1 8815
Esyt1 8442
Rhof 8157
Add3 8016
Sowahc 7962
Diaph1 7686
Cav1 7322
Depdc1b 6978
Arhgap32 6944
Arhgap12 6937
Tmpo 6445
Arhgap21 5837
Steap3 5653
Pik3r1 5026
Arhgap1 4998
Arhgap39 4867
Pik3r2 4624
Mtmr1 4451
Arhgap5 3728
Lmnb1 3657
Fam169a 3594
Akap12 3191
Diaph2 2916
Capzb 2846
Diaph3 1931
Vangl1 1705
Rab7 1274
Actn1 1214
Srgap2 1107
Syde1 -22
Basp1 -724
Slc4a7 -912
Mcam -1154
Baiap2l2 -2598
Myo9b -3018
Vamp3 -3114
Senp1 -3884
Actb -7870


PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
set PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
setSize 14
pANOVA 0.0238
s.dist 0.349
p.adjustANOVA 0.107


Top enriched genes
Top 20 genes
GeneID Gene Rank
Elmo1 8839
Rac1 8591
Rasa1 8289
Crk 6794
Arhgap35 6278
Ptk6 5620
Bcar1 4186
Kras 3748
Elmo2 3372
Dock1 2204
Rhoa 2054
Pxn -949
Hras -3606
Nras -4344

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elmo1 8839
Rac1 8591
Rasa1 8289
Crk 6794
Arhgap35 6278
Ptk6 5620
Bcar1 4186
Kras 3748
Elmo2 3372
Dock1 2204
Rhoa 2054
Pxn -949
Hras -3606
Nras -4344


NUCLEOTIDE LIKE PURINERGIC RECEPTORS
set NUCLEOTIDE LIKE PURINERGIC RECEPTORS
setSize 13
pANOVA 0.03
s.dist 0.348
p.adjustANOVA 0.122


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gpr17 9197
P2ry1 9156
Adora1 8007
P2ry13 7043
Adora2a 5293
Lpar4 4676
Adora2b 3476
P2ry12 2825
P2ry6 2635
P2ry14 68
Lpar6 33
Adora3 -1047
P2ry2 -4092

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpr17 9197
P2ry1 9156
Adora1 8007
P2ry13 7043
Adora2a 5293
Lpar4 4676
Adora2b 3476
P2ry12 2825
P2ry6 2635
P2ry14 68
Lpar6 33
Adora3 -1047
P2ry2 -4092


CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
set CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
setSize 49
pANOVA 2.92e-05
s.dist 0.345
p.adjustANOVA 0.000858


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rp2 9161
Lztfl1 8991
Exoc5 8427
Exoc7 8318
Exoc3 8205
Tcp1 8148
Unc119b 8116
Arf4 7436
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6619
Bbs7 6426
Rab11fip3 6242
Pde6d 6160
Cct5 6047
Gbf1 5756
Ttc8 5748

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rp2 9161
Lztfl1 8991
Exoc5 8427
Exoc7 8318
Exoc3 8205
Tcp1 8148
Unc119b 8116
Arf4 7436
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6619
Bbs7 6426
Rab11fip3 6242
Pde6d 6160
Cct5 6047
Gbf1 5756
Ttc8 5748
Bbs10 5623
Bbs4 5542
Cct4 5522
Smo 5124
Cys1 4284
Rab11a 4164
Exoc1 4051
Cct2 3790
Sstr3 3328
Cct8 3157
Rab8a 2934
Arl13b 2810
Exoc4 2471
Exoc2 1209
Exoc8 1073
Bbs2 307
Exoc6 86
Inpp5e 44
Asap1 21
Bbs12 -115
Pkd2 -195
Bbs9 -196
Bbip1 -690
Cnga4 -1817
Arl3 -2284
Pkd1 -2882
Nphp3 -3681
Bbs5 -4885
Cngb1 -8095


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report