date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik -2.3583781 -1.1332185
0610009E02Rik -0.4921631 -0.3290659
0610009L18Rik -1.5061599 0.1306738
0610010K14Rik -0.7608005 -0.3126674
0610012G03Rik -0.6314820 -0.2034285
0610030E20Rik 1.2199694 -0.5747514

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 17243
duplicated_genes_present 0
num_profile_genes_in_sets 8411
num_profile_genes_not_in_sets 8832
profile_pearson_correl 0.75024
profile_spearman_correl 0.73451

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 428
num_genesets_included 1176

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 284

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 6.91e-04 5.60e-03 0.892 -0.692 -0.56300 1.51e-04 2.05e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 8.83e-04 6.62e-03 0.840 0.684 0.48600 1.78e-04 7.73e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.39e-05 5.39e-04 0.833 0.564 0.61300 5.59e-05 1.22e-05
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.04e-03 3.65e-02 0.711 -0.515 -0.49000 3.09e-03 4.89e-03
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.35e-02 5.43e-02 0.669 0.452 0.49300 9.38e-03 4.61e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 2.62e-05 4.59e-04 0.643 -0.480 -0.42800 7.65e-06 6.59e-05
INTERACTION BETWEEN L1 AND ANKYRINS 27 2.13e-05 3.85e-04 0.632 0.515 0.36600 3.56e-06 9.82e-04
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.34e-03 9.27e-03 0.618 0.426 0.44700 9.73e-04 5.34e-04
P75NTR REGULATES AXONOGENESIS 10 3.97e-02 1.25e-01 0.611 -0.439 -0.42400 1.62e-02 2.01e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.79e-04 2.83e-03 0.592 0.381 0.45300 7.63e-04 6.46e-05
MITOCHONDRIAL TRANSLATION 93 9.33e-13 2.19e-10 0.586 -0.401 -0.42800 2.46e-11 9.59e-13
LGI ADAM INTERACTIONS 14 1.04e-02 4.46e-02 0.583 0.466 0.35100 2.53e-03 2.32e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 2.29e-04 2.47e-03 0.572 0.361 0.44400 9.45e-04 4.75e-05
CRISTAE FORMATION 31 1.74e-04 1.98e-03 0.569 -0.397 -0.40700 1.29e-04 8.93e-05
SIGNALING BY LEPTIN 10 6.14e-02 1.69e-01 0.568 0.402 0.40200 2.79e-02 2.77e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 5.96e-03 2.92e-02 0.559 -0.392 -0.39800 3.12e-03 2.65e-03
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 2.71e-03 1.64e-02 0.554 -0.444 -0.33200 5.87e-04 1.02e-02
RUNX3 REGULATES NOTCH SIGNALING 13 1.83e-02 7.01e-02 0.552 0.316 0.45200 4.84e-02 4.73e-03
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 6.81e-04 5.57e-03 0.544 0.263 0.47600 4.21e-02 2.27e-04
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 5.83e-03 2.88e-02 0.544 0.206 0.50300 2.38e-01 3.84e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 3.81e-02 1.21e-01 0.543 0.445 0.31200 1.07e-02 7.34e-02
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 5.67e-02 1.59e-01 0.542 0.320 0.43800 8.02e-02 1.66e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.37e-03 9.30e-03 0.541 -0.393 -0.37100 5.25e-04 1.04e-03
RESPIRATORY ELECTRON TRANSPORT 102 8.14e-12 9.57e-10 0.539 -0.384 -0.37900 2.08e-11 3.94e-11
RORA ACTIVATES GENE EXPRESSION 18 8.95e-03 3.91e-02 0.534 0.416 0.33600 2.26e-03 1.36e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.20e-02 4.97e-02 0.531 -0.362 -0.38900 7.84e-03 4.27e-03
ENDOSOMAL VACUOLAR PATHWAY 10 8.02e-04 6.08e-03 0.529 -0.523 -0.07970 4.16e-03 6.63e-01
INTERLEUKIN 6 SIGNALING 10 8.59e-02 2.07e-01 0.529 0.353 0.39300 5.31e-02 3.12e-02
PENTOSE PHOSPHATE PATHWAY 13 4.24e-02 1.31e-01 0.525 -0.393 -0.34900 1.42e-02 2.94e-02
E2F MEDIATED REGULATION OF DNA REPLICATION 20 8.87e-03 3.89e-02 0.522 -0.357 -0.38000 5.71e-03 3.25e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 7.52e-02 1.91e-01 0.521 -0.358 -0.37800 3.98e-02 2.99e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 4.72e-02 1.42e-01 0.519 0.382 0.35100 1.71e-02 2.85e-02
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 1.03e-04 1.25e-03 0.517 0.331 0.39800 4.21e-04 2.22e-05
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.67e-04 4.07e-03 0.517 0.333 0.39500 1.11e-03 1.10e-04
COMPLEX I BIOGENESIS 56 2.97e-06 6.60e-05 0.513 -0.361 -0.36500 3.01e-06 2.30e-06
ACTIVATION OF SMO 16 2.62e-02 9.14e-02 0.513 0.358 0.36800 1.32e-02 1.09e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 7.88e-03 3.61e-02 0.504 0.389 0.32100 2.04e-03 1.09e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.42e-12 2.39e-10 0.504 -0.353 -0.35900 9.66e-12 3.90e-12
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.06e-03 7.63e-03 0.500 -0.376 -0.32900 2.89e-04 1.51e-03
MITOCHONDRIAL PROTEIN IMPORT 63 1.37e-06 3.26e-05 0.498 -0.347 -0.35700 1.86e-06 9.42e-07
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 3.37e-07 9.68e-06 0.495 -0.391 -0.30400 5.11e-08 2.19e-05
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 6.20e-09 2.60e-07 0.493 -0.376 -0.31800 1.31e-09 2.85e-07
ORC1 REMOVAL FROM CHROMATIN 68 4.77e-07 1.25e-05 0.493 -0.370 -0.32600 1.33e-07 3.40e-06
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 5.11e-02 1.49e-01 0.491 -0.405 -0.27800 1.50e-02 9.58e-02
METABOLISM OF POLYAMINES 58 1.55e-06 3.50e-05 0.489 -0.393 -0.29200 2.31e-07 1.21e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 3.97e-06 8.50e-05 0.488 -0.392 -0.29100 6.14e-07 2.17e-04
RECEPTOR MEDIATED MITOPHAGY 11 6.93e-02 1.81e-01 0.486 -0.401 -0.27400 2.12e-02 1.16e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 2.80e-05 4.77e-04 0.486 -0.386 -0.29500 4.78e-06 4.66e-04
RETINOID CYCLE DISEASE EVENTS 10 4.56e-04 4.00e-03 0.485 -0.485 0.00194 7.96e-03 9.92e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 1.10e-01 2.44e-01 0.484 -0.295 -0.38300 1.06e-01 3.58e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 6.91e-04 5.60e-03 0.89200 -0.692000 -0.563000 1.51e-04 2.05e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 8.83e-04 6.62e-03 0.84000 0.684000 0.486000 1.78e-04 7.73e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.39e-05 5.39e-04 0.83300 0.564000 0.613000 5.59e-05 1.22e-05
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.04e-03 3.65e-02 0.71100 -0.515000 -0.490000 3.09e-03 4.89e-03
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.35e-02 5.43e-02 0.66900 0.452000 0.493000 9.38e-03 4.61e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 2.62e-05 4.59e-04 0.64300 -0.480000 -0.428000 7.65e-06 6.59e-05
INTERACTION BETWEEN L1 AND ANKYRINS 27 2.13e-05 3.85e-04 0.63200 0.515000 0.366000 3.56e-06 9.82e-04
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.34e-03 9.27e-03 0.61800 0.426000 0.447000 9.73e-04 5.34e-04
P75NTR REGULATES AXONOGENESIS 10 3.97e-02 1.25e-01 0.61100 -0.439000 -0.424000 1.62e-02 2.01e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.79e-04 2.83e-03 0.59200 0.381000 0.453000 7.63e-04 6.46e-05
MITOCHONDRIAL TRANSLATION 93 9.33e-13 2.19e-10 0.58600 -0.401000 -0.428000 2.46e-11 9.59e-13
LGI ADAM INTERACTIONS 14 1.04e-02 4.46e-02 0.58300 0.466000 0.351000 2.53e-03 2.32e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 2.29e-04 2.47e-03 0.57200 0.361000 0.444000 9.45e-04 4.75e-05
CRISTAE FORMATION 31 1.74e-04 1.98e-03 0.56900 -0.397000 -0.407000 1.29e-04 8.93e-05
SIGNALING BY LEPTIN 10 6.14e-02 1.69e-01 0.56800 0.402000 0.402000 2.79e-02 2.77e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 5.96e-03 2.92e-02 0.55900 -0.392000 -0.398000 3.12e-03 2.65e-03
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 2.71e-03 1.64e-02 0.55400 -0.444000 -0.332000 5.87e-04 1.02e-02
RUNX3 REGULATES NOTCH SIGNALING 13 1.83e-02 7.01e-02 0.55200 0.316000 0.452000 4.84e-02 4.73e-03
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 6.81e-04 5.57e-03 0.54400 0.263000 0.476000 4.21e-02 2.27e-04
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 5.83e-03 2.88e-02 0.54400 0.206000 0.503000 2.38e-01 3.84e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 3.81e-02 1.21e-01 0.54300 0.445000 0.312000 1.07e-02 7.34e-02
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 5.67e-02 1.59e-01 0.54200 0.320000 0.438000 8.02e-02 1.66e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.37e-03 9.30e-03 0.54100 -0.393000 -0.371000 5.25e-04 1.04e-03
RESPIRATORY ELECTRON TRANSPORT 102 8.14e-12 9.57e-10 0.53900 -0.384000 -0.379000 2.08e-11 3.94e-11
RORA ACTIVATES GENE EXPRESSION 18 8.95e-03 3.91e-02 0.53400 0.416000 0.336000 2.26e-03 1.36e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.20e-02 4.97e-02 0.53100 -0.362000 -0.389000 7.84e-03 4.27e-03
ENDOSOMAL VACUOLAR PATHWAY 10 8.02e-04 6.08e-03 0.52900 -0.523000 -0.079700 4.16e-03 6.63e-01
INTERLEUKIN 6 SIGNALING 10 8.59e-02 2.07e-01 0.52900 0.353000 0.393000 5.31e-02 3.12e-02
PENTOSE PHOSPHATE PATHWAY 13 4.24e-02 1.31e-01 0.52500 -0.393000 -0.349000 1.42e-02 2.94e-02
E2F MEDIATED REGULATION OF DNA REPLICATION 20 8.87e-03 3.89e-02 0.52200 -0.357000 -0.380000 5.71e-03 3.25e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 7.52e-02 1.91e-01 0.52100 -0.358000 -0.378000 3.98e-02 2.99e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 4.72e-02 1.42e-01 0.51900 0.382000 0.351000 1.71e-02 2.85e-02
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 1.03e-04 1.25e-03 0.51700 0.331000 0.398000 4.21e-04 2.22e-05
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.67e-04 4.07e-03 0.51700 0.333000 0.395000 1.11e-03 1.10e-04
COMPLEX I BIOGENESIS 56 2.97e-06 6.60e-05 0.51300 -0.361000 -0.365000 3.01e-06 2.30e-06
ACTIVATION OF SMO 16 2.62e-02 9.14e-02 0.51300 0.358000 0.368000 1.32e-02 1.09e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 7.88e-03 3.61e-02 0.50400 0.389000 0.321000 2.04e-03 1.09e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.42e-12 2.39e-10 0.50400 -0.353000 -0.359000 9.66e-12 3.90e-12
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.06e-03 7.63e-03 0.50000 -0.376000 -0.329000 2.89e-04 1.51e-03
MITOCHONDRIAL PROTEIN IMPORT 63 1.37e-06 3.26e-05 0.49800 -0.347000 -0.357000 1.86e-06 9.42e-07
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 3.37e-07 9.68e-06 0.49500 -0.391000 -0.304000 5.11e-08 2.19e-05
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 6.20e-09 2.60e-07 0.49300 -0.376000 -0.318000 1.31e-09 2.85e-07
ORC1 REMOVAL FROM CHROMATIN 68 4.77e-07 1.25e-05 0.49300 -0.370000 -0.326000 1.33e-07 3.40e-06
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 5.11e-02 1.49e-01 0.49100 -0.405000 -0.278000 1.50e-02 9.58e-02
METABOLISM OF POLYAMINES 58 1.55e-06 3.50e-05 0.48900 -0.393000 -0.292000 2.31e-07 1.21e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 3.97e-06 8.50e-05 0.48800 -0.392000 -0.291000 6.14e-07 2.17e-04
RECEPTOR MEDIATED MITOPHAGY 11 6.93e-02 1.81e-01 0.48600 -0.401000 -0.274000 2.12e-02 1.16e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 2.80e-05 4.77e-04 0.48600 -0.386000 -0.295000 4.78e-06 4.66e-04
RETINOID CYCLE DISEASE EVENTS 10 4.56e-04 4.00e-03 0.48500 -0.485000 0.001940 7.96e-03 9.92e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 1.10e-01 2.44e-01 0.48400 -0.295000 -0.383000 1.06e-01 3.58e-02
PHASE 2 PLATEAU PHASE 12 7.27e-02 1.86e-01 0.48100 0.293000 0.381000 7.90e-02 2.22e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.03e-02 7.47e-02 0.48000 0.250000 0.409000 9.41e-02 6.04e-03
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 4.66e-03 2.53e-02 0.47600 0.318000 0.354000 4.24e-03 1.44e-03
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 5.84e-03 2.88e-02 0.47600 0.368000 0.302000 1.47e-03 8.92e-03
CD28 DEPENDENT VAV1 PATHWAY 11 5.63e-02 1.59e-01 0.47600 -0.409000 -0.243000 1.88e-02 1.63e-01
TIGHT JUNCTION INTERACTIONS 17 2.02e-02 7.46e-02 0.47500 -0.391000 -0.271000 5.31e-03 5.32e-02
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 4.33e-02 1.34e-01 0.47200 0.314000 0.353000 2.96e-02 1.46e-02
PHOSPHORYLATION OF THE APC C 18 2.01e-02 7.45e-02 0.47000 -0.381000 -0.276000 5.18e-03 4.29e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 6.35e-06 1.29e-04 0.47000 -0.366000 -0.294000 1.13e-06 9.30e-05
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 6.95e-04 5.60e-03 0.47000 -0.461000 -0.090200 2.82e-03 5.59e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 71 7.76e-07 1.94e-05 0.46700 -0.361000 -0.296000 1.42e-07 1.57e-05
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 5.70e-02 1.60e-01 0.46700 0.286000 0.369000 6.35e-02 1.69e-02
EARLY PHASE OF HIV LIFE CYCLE 13 8.55e-02 2.07e-01 0.46600 -0.316000 -0.342000 4.87e-02 3.25e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 83 1.86e-07 6.09e-06 0.46200 -0.343000 -0.311000 6.78e-08 1.01e-06
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.54e-02 9.00e-02 0.46200 -0.356000 -0.294000 7.24e-03 2.64e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.18e-14 8.55e-12 0.46100 -0.320000 -0.332000 4.21e-13 5.99e-14
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 5.51e-02 1.58e-01 0.45900 0.289000 0.357000 5.25e-02 1.67e-02
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.45e-04 1.71e-03 0.45400 0.139000 0.432000 2.50e-01 3.31e-04
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 3.49e-05 5.47e-04 0.45300 -0.355000 -0.281000 6.36e-06 3.47e-04
DNA REPLICATION PRE INITIATION 80 4.05e-07 1.11e-05 0.45300 -0.347000 -0.292000 8.40e-08 6.38e-06
BRANCHED CHAIN AMINO ACID CATABOLISM 21 5.15e-03 2.66e-02 0.45300 -0.396000 -0.220000 1.70e-03 8.13e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 64 5.82e-06 1.20e-04 0.45200 -0.353000 -0.282000 1.02e-06 9.54e-05
PROTEIN UBIQUITINATION 70 7.48e-07 1.91e-05 0.45200 -0.367000 -0.264000 1.10e-07 1.38e-04
PROCESSING OF SMDT1 16 5.92e-02 1.64e-01 0.45100 -0.310000 -0.328000 3.16e-02 2.32e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 4.60e-06 9.66e-05 0.45100 -0.342000 -0.295000 1.11e-06 2.63e-05
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 15 5.05e-02 1.48e-01 0.44500 0.256000 0.364000 8.57e-02 1.46e-02
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 5.63e-02 1.59e-01 0.44200 0.308000 0.318000 2.80e-02 2.34e-02
DEGRADATION OF DVL 56 6.38e-05 8.62e-04 0.44000 -0.334000 -0.286000 1.51e-05 2.14e-04
INTERLEUKIN 12 SIGNALING 36 1.68e-03 1.11e-02 0.44000 -0.342000 -0.276000 3.77e-04 4.22e-03
HIV TRANSCRIPTION INITIATION 45 3.87e-04 3.62e-03 0.43900 -0.338000 -0.280000 8.62e-05 1.15e-03
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 3.58e-02 1.16e-01 0.43900 -0.314000 -0.307000 1.52e-02 1.75e-02
CRMPS IN SEMA3A SIGNALING 16 5.85e-02 1.63e-01 0.43900 0.342000 0.274000 1.77e-02 5.79e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 2.90e-05 4.87e-04 0.43700 -0.339000 -0.276000 5.62e-06 2.19e-04
CITRIC ACID CYCLE TCA CYCLE 22 1.30e-02 5.30e-02 0.43600 -0.245000 -0.362000 4.71e-02 3.33e-03
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.10e-02 1.04e-01 0.43600 -0.349000 -0.261000 8.41e-03 4.93e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 6.51e-03 3.16e-02 0.43600 0.178000 0.398000 1.92e-01 3.49e-03
DNA REPLICATION 122 7.24e-10 5.18e-08 0.43500 -0.338000 -0.273000 1.11e-10 1.95e-07
ASPARTATE AND ASPARAGINE METABOLISM 11 8.20e-02 2.03e-01 0.43300 -0.213000 -0.378000 2.22e-01 3.01e-02
RAB GERANYLGERANYLATION 58 1.43e-05 2.81e-04 0.43200 -0.357000 -0.243000 2.51e-06 1.38e-03
PROCESSING AND ACTIVATION OF SUMO 10 1.27e-01 2.67e-01 0.43100 -0.366000 -0.227000 4.51e-02 2.14e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.11e-02 4.70e-02 0.43000 -0.339000 -0.264000 2.74e-03 2.00e-02
S PHASE 154 2.68e-12 3.78e-10 0.42900 -0.340000 -0.262000 3.08e-13 2.16e-08
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 3.18e-03 1.85e-02 0.42900 -0.356000 -0.239000 7.33e-04 2.35e-02
MET ACTIVATES RAP1 AND RAC1 10 1.89e-01 3.56e-01 0.42900 -0.331000 -0.273000 7.03e-02 1.35e-01
CS DS DEGRADATION 14 8.49e-02 2.07e-01 0.42700 0.255000 0.343000 9.88e-02 2.64e-02
GLUTATHIONE CONJUGATION 29 4.12e-03 2.28e-02 0.41900 -0.352000 -0.226000 1.02e-03 3.50e-02
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 3.15e-02 1.05e-01 0.41800 -0.384000 -0.165000 1.65e-02 3.03e-01
METHYLATION 11 7.58e-02 1.92e-01 0.41800 -0.374000 -0.187000 3.18e-02 2.83e-01
STABILIZATION OF P53 55 2.11e-04 2.32e-03 0.41700 -0.314000 -0.274000 5.51e-05 4.38e-04
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 9.39e-05 1.15e-03 0.41600 -0.347000 -0.229000 1.85e-05 4.62e-03
RRNA PROCESSING IN THE MITOCHONDRION 10 2.19e-01 3.94e-01 0.41600 -0.276000 -0.310000 1.30e-01 8.94e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 3.30e-05 5.31e-04 0.41500 -0.305000 -0.282000 1.22e-05 5.21e-05
CHOLESTEROL BIOSYNTHESIS 24 9.04e-03 3.94e-02 0.41300 -0.212000 -0.355000 7.24e-02 2.64e-03
DEGRADATION OF AXIN 54 1.60e-04 1.87e-03 0.41100 -0.329000 -0.246000 2.92e-05 1.76e-03
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 28 2.61e-03 1.61e-02 0.41000 -0.361000 -0.193000 9.36e-04 7.68e-02
DEGRADATION OF GLI1 BY THE PROTEASOME 58 1.38e-04 1.64e-03 0.40800 -0.319000 -0.255000 2.71e-05 7.89e-04
RHOBTB3 ATPASE CYCLE 10 1.18e-01 2.54e-01 0.40800 -0.361000 -0.190000 4.81e-02 2.98e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 8.33e-03 3.76e-02 0.40800 -0.370000 -0.170000 4.14e-03 1.88e-01
PROTEIN METHYLATION 17 5.19e-02 1.51e-01 0.40600 -0.339000 -0.224000 1.56e-02 1.10e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.99e-01 3.67e-01 0.40600 -0.239000 -0.328000 1.90e-01 7.25e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 3.26e-06 7.10e-05 0.40500 -0.316000 -0.254000 5.76e-07 5.60e-05
CELLULAR RESPONSE TO HYPOXIA 73 2.65e-05 4.59e-04 0.40400 -0.305000 -0.264000 6.59e-06 9.47e-05
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 1.48e-02 5.80e-02 0.40300 0.279000 0.290000 8.07e-03 5.95e-03
PYRUVATE METABOLISM 27 1.34e-02 5.39e-02 0.40300 -0.327000 -0.236000 3.31e-03 3.41e-02
INTERLEUKIN 7 SIGNALING 19 6.89e-02 1.80e-01 0.40100 0.269000 0.297000 4.23e-02 2.49e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 1.69e-05 3.21e-04 0.40000 -0.294000 -0.271000 6.12e-06 3.19e-05
INSULIN RECEPTOR RECYCLING 20 3.33e-02 1.10e-01 0.39900 -0.334000 -0.218000 9.62e-03 9.11e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.14e-01 2.49e-01 0.39600 0.322000 0.231000 3.72e-02 1.35e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 1.99e-04 2.23e-03 0.39300 -0.326000 -0.220000 3.94e-05 5.71e-03
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 2.01e-02 7.45e-02 0.39300 -0.291000 -0.264000 6.77e-03 1.39e-02
FCERI MEDIATED NF KB ACTIVATION 77 3.70e-05 5.72e-04 0.39100 -0.285000 -0.268000 1.51e-05 4.90e-05
REGULATION OF TLR BY ENDOGENOUS LIGAND 14 1.56e-01 3.09e-01 0.39100 -0.286000 -0.266000 6.35e-02 8.54e-02
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.72e-03 1.12e-02 0.39000 0.212000 0.327000 2.19e-02 4.02e-04
UNWINDING OF DNA 12 7.80e-03 3.58e-02 0.38900 -0.386000 -0.048300 2.05e-02 7.72e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 3.75e-02 1.20e-01 0.38900 -0.299000 -0.249000 1.12e-02 3.45e-02
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 60 6.28e-05 8.58e-04 0.38800 -0.326000 -0.211000 1.27e-05 4.62e-03
SCAVENGING OF HEME FROM PLASMA 10 1.85e-01 3.50e-01 0.38700 -0.201000 -0.330000 2.70e-01 7.07e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 2.85e-02 9.81e-02 0.38600 0.120000 0.367000 4.53e-01 2.21e-02
REGULATION OF BACH1 ACTIVITY 11 2.17e-01 3.92e-01 0.38600 -0.304000 -0.238000 8.13e-02 1.72e-01
G1 S DNA DAMAGE CHECKPOINTS 66 2.17e-04 2.37e-03 0.38500 -0.266000 -0.278000 1.90e-04 9.44e-05
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.58e-01 3.11e-01 0.38400 -0.230000 -0.308000 1.51e-01 5.47e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 5.31e-02 1.53e-01 0.38200 0.135000 0.357000 4.19e-01 3.21e-02
PERK REGULATES GENE EXPRESSION 28 1.47e-02 5.80e-02 0.38200 -0.316000 -0.214000 3.80e-03 5.00e-02
FGFR2 MUTANT RECEPTOR ACTIVATION 27 3.25e-02 1.08e-01 0.38000 -0.254000 -0.283000 2.26e-02 1.08e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 6.73e-05 8.99e-04 0.37900 -0.379000 0.006600 3.32e-03 9.59e-01
FGFR2 LIGAND BINDING AND ACTIVATION 13 6.73e-02 1.78e-01 0.37900 -0.158000 -0.345000 3.25e-01 3.15e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 1.98e-02 7.43e-02 0.37900 -0.300000 -0.231000 5.17e-03 3.12e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.73e-01 3.32e-01 0.37900 -0.312000 -0.215000 6.16e-02 1.97e-01
PROTEIN LOCALIZATION 157 9.45e-10 5.85e-08 0.37900 -0.297000 -0.234000 1.30e-10 4.15e-07
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 2.20e-02 7.93e-02 0.37800 -0.369000 -0.083900 2.69e-02 6.15e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 22 5.86e-02 1.63e-01 0.37800 -0.290000 -0.243000 1.85e-02 4.86e-02
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 13 2.72e-02 9.45e-02 0.37800 0.109000 0.362000 4.98e-01 2.38e-02
MITOTIC G1 PHASE AND G1 S TRANSITION 141 5.41e-09 2.45e-07 0.37500 -0.301000 -0.224000 6.86e-10 4.27e-06
METALLOPROTEASE DUBS 25 3.01e-02 1.02e-01 0.37500 -0.217000 -0.306000 6.02e-02 8.17e-03
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 2.97e-04 2.91e-03 0.37200 0.320000 0.190000 7.92e-05 1.90e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.24e-06 3.05e-05 0.36900 -0.346000 -0.129000 4.23e-06 8.71e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 1.93e-01 3.60e-01 0.36900 -0.290000 -0.228000 7.07e-02 1.55e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 9.28e-02 2.19e-01 0.36700 -0.288000 -0.227000 2.97e-02 8.63e-02
SIGNALING BY NTRK3 TRKC 17 1.37e-01 2.83e-01 0.36500 0.244000 0.272000 8.21e-02 5.23e-02
PHASE II CONJUGATION OF COMPOUNDS 63 6.90e-05 9.02e-04 0.36400 -0.313000 -0.186000 1.79e-05 1.05e-02
HYALURONAN METABOLISM 15 1.80e-01 3.41e-01 0.36400 0.261000 0.254000 8.03e-02 8.90e-02
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.01e-01 2.32e-01 0.36400 0.264000 0.250000 4.09e-02 5.28e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 2.46e-02 8.77e-02 0.36300 -0.346000 -0.110000 2.03e-02 4.59e-01
INTERLEUKIN 15 SIGNALING 12 2.54e-01 4.37e-01 0.36300 0.262000 0.252000 1.17e-01 1.31e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 3.07e-03 1.80e-02 0.36300 -0.254000 -0.259000 1.70e-03 1.39e-03
G2 M CHECKPOINTS 133 2.72e-07 7.98e-06 0.36300 -0.266000 -0.247000 1.26e-07 9.02e-07
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 1.02e-02 4.37e-02 0.36100 -0.303000 -0.197000 2.63e-03 4.98e-02
OTHER SEMAPHORIN INTERACTIONS 19 7.68e-02 1.93e-01 0.36000 0.299000 0.201000 2.41e-02 1.29e-01
DARPP 32 EVENTS 23 4.81e-02 1.44e-01 0.36000 -0.296000 -0.205000 1.40e-02 8.93e-02
INTERLEUKIN 37 SIGNALING 18 8.25e-02 2.03e-01 0.35800 0.301000 0.193000 2.69e-02 1.56e-01
INTERLEUKIN 12 FAMILY SIGNALING 43 4.91e-03 2.62e-02 0.35600 -0.287000 -0.210000 1.11e-03 1.70e-02
REGULATION OF PTEN STABILITY AND ACTIVITY 68 1.72e-04 1.98e-03 0.35600 -0.292000 -0.204000 3.20e-05 3.57e-03
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 1.38e-01 2.85e-01 0.35500 0.136000 0.328000 4.58e-01 7.22e-02
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 1.38e-01 2.85e-01 0.35500 0.136000 0.328000 4.58e-01 7.22e-02
FORMATION OF APOPTOSOME 10 3.20e-01 5.04e-01 0.35500 -0.273000 -0.228000 1.36e-01 2.13e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 2.68e-01 4.52e-01 0.35300 0.195000 0.295000 2.86e-01 1.06e-01
TRANSLATION 287 2.38e-17 2.80e-14 0.35300 -0.297000 -0.190000 4.58e-18 3.22e-08
RAS PROCESSING 24 1.60e-02 6.19e-02 0.35300 -0.318000 -0.153000 7.03e-03 1.94e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 2.98e-02 1.01e-01 0.35200 -0.273000 -0.221000 8.42e-03 3.28e-02
MATURATION OF NUCLEOPROTEIN 10 1.68e-01 3.26e-01 0.35200 -0.320000 -0.147000 8.01e-02 4.22e-01
TRANSLESION SYNTHESIS BY POLK 17 1.52e-01 3.05e-01 0.35000 -0.269000 -0.224000 5.48e-02 1.10e-01
TRIGLYCERIDE CATABOLISM 14 1.55e-02 6.04e-02 0.34900 -0.344000 -0.060100 2.59e-02 6.97e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 1.46e-01 2.97e-01 0.34900 0.232000 0.260000 8.85e-02 5.58e-02
RHOC GTPASE CYCLE 74 3.79e-04 3.60e-03 0.34600 0.262000 0.226000 9.51e-05 7.86e-04
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 3.87e-05 5.84e-04 0.34600 -0.283000 -0.200000 6.68e-06 1.47e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 4.48e-02 1.37e-01 0.34600 -0.295000 -0.180000 1.43e-02 1.35e-01
RHOB GTPASE CYCLE 68 7.76e-04 6.00e-03 0.34600 0.260000 0.228000 2.14e-04 1.15e-03
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 3.65e-02 1.18e-01 0.34600 0.335000 0.083600 3.63e-02 6.02e-01
CLEC7A DECTIN 1 SIGNALING 95 5.02e-05 7.22e-04 0.34500 -0.258000 -0.229000 1.44e-05 1.14e-04
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 9.28e-02 2.19e-01 0.34300 -0.297000 -0.171000 3.38e-02 2.23e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.08e-02 4.62e-02 0.34200 -0.204000 -0.275000 2.57e-02 2.63e-03
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.97e-01 4.83e-01 0.34100 -0.248000 -0.234000 1.37e-01 1.60e-01
NRAGE SIGNALS DEATH THROUGH JNK 55 2.98e-03 1.77e-02 0.34100 0.264000 0.216000 7.14e-04 5.54e-03
GP1B IX V ACTIVATION SIGNALLING 11 3.13e-01 4.97e-01 0.34000 0.263000 0.215000 1.30e-01 2.18e-01
INTERFERON ALPHA BETA SIGNALING 56 4.43e-15 2.61e-12 0.33800 -0.303000 0.151000 8.83e-05 5.14e-02
BIOTIN TRANSPORT AND METABOLISM 11 1.59e-01 3.13e-01 0.33800 0.139000 0.308000 4.24e-01 7.67e-02
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 1.04e-02 4.46e-02 0.33700 -0.028100 0.336000 8.72e-01 5.37e-02
NEUREXINS AND NEUROLIGINS 54 2.74e-03 1.65e-02 0.33700 0.270000 0.201000 5.94e-04 1.05e-02
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.06e-01 3.77e-01 0.33600 -0.248000 -0.227000 8.61e-02 1.15e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 9.76e-04 7.22e-03 0.33500 0.315000 0.115000 1.07e-03 2.32e-01
MRNA CAPPING 29 4.81e-02 1.44e-01 0.33500 -0.264000 -0.206000 1.40e-02 5.44e-02
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 2.45e-01 4.25e-01 0.33500 0.216000 0.255000 1.61e-01 9.81e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 9.62e-02 2.24e-01 0.33500 -0.320000 -0.099100 6.65e-02 5.69e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 1.04e-01 2.36e-01 0.33400 -0.222000 -0.250000 6.55e-02 3.80e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 6.15e-05 8.51e-04 0.33400 -0.278000 -0.185000 1.18e-05 3.58e-03
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 2.85e-02 9.81e-02 0.33400 0.178000 0.283000 9.75e-02 8.38e-03
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 1.26e-01 2.67e-01 0.33400 -0.129000 -0.308000 4.39e-01 6.50e-02
GLUTATHIONE SYNTHESIS AND RECYCLING 11 3.29e-01 5.13e-01 0.33300 -0.258000 -0.212000 1.39e-01 2.24e-01
HS GAG DEGRADATION 21 9.36e-02 2.21e-01 0.33300 0.274000 0.189000 2.98e-02 1.34e-01
BUDDING AND MATURATION OF HIV VIRION 27 2.38e-02 8.52e-02 0.33200 -0.292000 -0.158000 8.55e-03 1.55e-01
DERMATAN SULFATE BIOSYNTHESIS 11 3.33e-01 5.18e-01 0.33200 0.256000 0.212000 1.42e-01 2.24e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 1.11e-01 2.45e-01 0.33200 -0.212000 -0.256000 8.55e-02 3.79e-02
PHASE 4 RESTING MEMBRANE POTENTIAL 14 6.30e-03 3.07e-02 0.33200 -0.332000 0.002240 3.16e-02 9.88e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 5.22e-03 2.66e-02 0.33100 -0.327000 -0.051800 1.35e-02 6.96e-01
SULFUR AMINO ACID METABOLISM 23 6.74e-02 1.78e-01 0.33100 -0.278000 -0.180000 2.12e-02 1.34e-01
SIGNALING BY FGFR2 IIIA TM 19 1.21e-01 2.57e-01 0.33100 -0.272000 -0.188000 4.01e-02 1.56e-01
REGULATION OF RAS BY GAPS 67 9.51e-04 7.08e-03 0.33100 -0.263000 -0.200000 1.93e-04 4.65e-03
MET ACTIVATES PTK2 SIGNALING 28 5.21e-03 2.66e-02 0.33100 0.311000 0.113000 4.43e-03 3.00e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 4.39e-02 1.35e-01 0.33100 -0.240000 -0.227000 1.70e-02 2.39e-02
KINESINS 47 7.63e-04 5.94e-03 0.33000 0.298000 0.142000 4.01e-04 9.27e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 7.25e-03 3.43e-02 0.33000 0.201000 0.262000 1.58e-02 1.72e-03
FGFR1 LIGAND BINDING AND ACTIVATION 10 3.88e-01 5.79e-01 0.33000 -0.226000 -0.241000 2.16e-01 1.88e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.85e-03 1.71e-02 0.33000 -0.271000 -0.187000 6.34e-04 1.84e-02
PYROPTOSIS 21 7.95e-02 1.99e-01 0.32900 -0.280000 -0.174000 2.64e-02 1.68e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 4.85e-02 1.44e-01 0.32800 -0.313000 -0.099900 3.59e-02 5.03e-01
NEPHRIN FAMILY INTERACTIONS 23 1.17e-01 2.53e-01 0.32600 0.218000 0.242000 6.98e-02 4.42e-02
FORMATION OF INCISION COMPLEX IN GG NER 43 1.31e-02 5.30e-02 0.32500 -0.259000 -0.196000 3.25e-03 2.66e-02
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 4.34e-03 2.39e-02 0.32400 0.119000 0.301000 2.43e-01 3.17e-03
HEDGEHOG LIGAND BIOGENESIS 62 1.05e-03 7.61e-03 0.32200 -0.270000 -0.175000 2.38e-04 1.71e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 5.31e-02 1.53e-01 0.32100 -0.310000 -0.085200 4.48e-02 5.81e-01
RNA POLYMERASE I PROMOTER ESCAPE 46 2.23e-03 1.41e-02 0.32000 -0.284000 -0.147000 8.65e-04 8.37e-02
SEPARATION OF SISTER CHROMATIDS 166 4.76e-07 1.25e-05 0.32000 -0.226000 -0.226000 5.18e-07 4.90e-07
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION 10 1.14e-02 4.78e-02 0.32000 0.077500 -0.310000 6.71e-01 8.95e-02
C TYPE LECTIN RECEPTORS CLRS 114 2.62e-05 4.59e-04 0.32000 -0.247000 -0.202000 5.17e-06 1.89e-04
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 1.37e-02 5.48e-02 0.31900 -0.038500 0.317000 8.25e-01 6.88e-02
NGF STIMULATED TRANSCRIPTION 36 3.06e-05 5.08e-04 0.31900 -0.318000 -0.027400 9.79e-04 7.76e-01
ANTIGEN PROCESSING CROSS PRESENTATION 99 6.88e-06 1.37e-04 0.31900 -0.276000 -0.159000 2.07e-06 6.34e-03
IRON UPTAKE AND TRANSPORT 52 5.22e-03 2.66e-02 0.31800 -0.260000 -0.184000 1.20e-03 2.17e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 3.51e-02 1.15e-01 0.31800 0.178000 0.263000 8.06e-02 9.91e-03
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.19e-02 4.96e-02 0.31800 0.022600 0.317000 8.80e-01 3.34e-02
DNA STRAND ELONGATION 32 1.35e-03 9.27e-03 0.31800 -0.307000 -0.083500 2.66e-03 4.14e-01
N GLYCAN ANTENNAE ELONGATION 15 2.58e-04 2.71e-03 0.31700 -0.177000 0.263000 2.35e-01 7.77e-02
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 2.13e-01 3.86e-01 0.31600 -0.254000 -0.189000 7.86e-02 1.91e-01
CDC42 GTPASE CYCLE 154 1.39e-06 3.26e-05 0.31600 0.237000 0.209000 3.82e-07 7.80e-06
G2 M DNA DAMAGE CHECKPOINT 65 2.87e-03 1.71e-02 0.31600 -0.202000 -0.243000 4.97e-03 7.00e-04
CONDENSATION OF PROPHASE CHROMOSOMES 27 8.84e-03 3.89e-02 0.31600 -0.298000 -0.105000 7.39e-03 3.46e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 5.06e-03 2.66e-02 0.31500 -0.308000 -0.070400 9.11e-03 5.50e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 7.25e-03 3.43e-02 0.31400 -0.293000 -0.111000 5.42e-03 2.91e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 3.59e-01 5.47e-01 0.31300 -0.229000 -0.214000 1.69e-01 2.00e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 9.78e-03 4.25e-02 0.31300 0.190000 0.248000 2.00e-02 2.37e-03
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.42e-01 2.92e-01 0.31300 0.227000 0.215000 5.95e-02 7.39e-02
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 4.42e-02 1.35e-01 0.31200 -0.279000 -0.140000 1.80e-02 2.34e-01
EUKARYOTIC TRANSLATION INITIATION 115 4.73e-11 4.28e-09 0.31200 -0.303000 -0.075600 2.04e-08 1.62e-01
G PROTEIN ACTIVATION 22 2.68e-04 2.76e-03 0.31200 -0.039300 0.309000 7.50e-01 1.21e-02
CELL CYCLE CHECKPOINTS 241 2.41e-09 1.23e-07 0.31000 -0.216000 -0.223000 7.69e-09 2.69e-09
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 2.78e-04 2.83e-03 0.31000 0.254000 0.178000 5.30e-05 4.56e-03
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 1.70e-01 3.28e-01 0.31000 -0.183000 -0.250000 1.67e-01 5.96e-02
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 83 5.21e-05 7.38e-04 0.30900 -0.271000 -0.147000 1.91e-05 2.03e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 23 4.03e-02 1.26e-01 0.30900 -0.282000 -0.127000 1.94e-02 2.93e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 7.07e-02 1.83e-01 0.30800 0.047000 0.305000 7.87e-01 8.02e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 1.62e-01 3.15e-01 0.30800 0.161000 0.263000 2.52e-01 6.05e-02
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 6.87e-02 1.80e-01 0.30600 0.184000 0.244000 8.12e-02 2.07e-02
HOST INTERACTIONS OF HIV FACTORS 126 1.57e-05 3.03e-04 0.30500 -0.243000 -0.184000 2.59e-06 3.59e-04
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.92e-01 4.79e-01 0.30400 0.161000 0.258000 3.33e-01 1.22e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.58e-01 3.11e-01 0.30400 -0.271000 -0.137000 6.88e-02 3.59e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 3.27e-02 1.08e-01 0.30400 0.215000 0.215000 1.49e-02 1.48e-02
SIGNALING BY FGFR2 IN DISEASE 37 5.30e-02 1.53e-01 0.30300 -0.216000 -0.213000 2.28e-02 2.53e-02
METABOLISM OF PORPHYRINS 19 1.80e-01 3.41e-01 0.30300 -0.246000 -0.177000 6.39e-02 1.81e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 34 6.98e-03 3.34e-02 0.30300 -0.281000 -0.113000 4.62e-03 2.53e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.28e-01 5.13e-01 0.30200 -0.184000 -0.239000 2.50e-01 1.36e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.25e-01 4.01e-01 0.30100 0.215000 0.211000 1.05e-01 1.11e-01
PHASE 0 RAPID DEPOLARISATION 28 9.02e-02 2.16e-01 0.30100 0.239000 0.183000 2.84e-02 9.45e-02
ACTIVATION OF RAC1 13 5.68e-02 1.59e-01 0.30100 -0.296000 -0.052300 6.43e-02 7.44e-01
RND2 GTPASE CYCLE 39 3.93e-02 1.24e-01 0.30000 0.187000 0.234000 4.32e-02 1.13e-02
DNA DAMAGE BYPASS 45 4.17e-03 2.30e-02 0.29800 -0.268000 -0.131000 1.86e-03 1.29e-01
SIGNALING BY NOTCH3 48 2.37e-04 2.53e-03 0.29800 0.084000 0.286000 3.14e-01 6.11e-04
ELASTIC FIBRE FORMATION 38 3.11e-03 1.82e-02 0.29800 0.102000 0.280000 2.75e-01 2.84e-03
RNA POLYMERASE III CHAIN ELONGATION 18 6.71e-02 1.78e-01 0.29800 -0.279000 -0.104000 4.03e-02 4.45e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 3.84e-01 5.74e-01 0.29800 -0.161000 -0.250000 3.78e-01 1.70e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 3.11e-05 5.08e-04 0.29700 -0.287000 -0.079000 1.61e-04 2.98e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 21 3.59e-02 1.16e-01 0.29700 -0.095100 -0.281000 4.51e-01 2.59e-02
ECM PROTEOGLYCANS 66 3.89e-03 2.18e-02 0.29600 0.237000 0.178000 8.66e-04 1.26e-02
REGULATION OF IFNA SIGNALING 12 2.19e-01 3.94e-01 0.29500 0.122000 0.269000 4.64e-01 1.07e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 14 3.51e-01 5.38e-01 0.29400 -0.207000 -0.209000 1.79e-01 1.76e-01
PURINE CATABOLISM 16 8.37e-02 2.05e-01 0.29400 -0.278000 -0.095300 5.38e-02 5.09e-01
METABOLISM OF COFACTORS 19 6.44e-02 1.73e-01 0.29400 -0.275000 -0.104000 3.80e-02 4.31e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 1.10e-01 2.44e-01 0.29400 -0.285000 -0.071700 8.72e-02 6.67e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 107 2.90e-12 3.78e-10 0.29400 -0.293000 -0.022700 1.65e-07 6.86e-01
REGULATION OF TNFR1 SIGNALING 34 1.97e-02 7.43e-02 0.29400 0.132000 0.263000 1.84e-01 8.04e-03
TRANSLESION SYNTHESIS BY POLH 19 1.02e-01 2.33e-01 0.29400 -0.265000 -0.127000 4.55e-02 3.39e-01
CYTOSOLIC TRNA AMINOACYLATION 24 1.03e-01 2.34e-01 0.29400 -0.156000 -0.249000 1.85e-01 3.50e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.43e-01 5.29e-01 0.29300 0.243000 0.164000 1.45e-01 3.25e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 1.36e-03 9.30e-03 0.29300 -0.286000 -0.066700 3.47e-03 4.94e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 9.40e-02 2.21e-01 0.29300 0.207000 0.207000 4.31e-02 4.27e-02
MITOTIC METAPHASE AND ANAPHASE 207 2.26e-07 7.20e-06 0.29200 -0.217000 -0.196000 7.98e-08 1.23e-06
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 1.61e-01 3.14e-01 0.29200 0.245000 0.158000 5.81e-02 2.20e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 1.10e-01 2.44e-01 0.29100 -0.249000 -0.151000 3.88e-02 2.09e-01
HEME BIOSYNTHESIS 13 2.94e-01 4.80e-01 0.29000 -0.247000 -0.153000 1.23e-01 3.40e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 1.48e-02 5.80e-02 0.28900 -0.266000 -0.114000 8.17e-03 2.58e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 1.20e-01 2.57e-01 0.28900 -0.248000 -0.148000 4.37e-02 2.30e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 3.19e-01 5.02e-01 0.28900 -0.183000 -0.224000 2.20e-01 1.33e-01
PRE NOTCH PROCESSING IN GOLGI 17 2.93e-01 4.79e-01 0.28800 0.209000 0.199000 1.36e-01 1.56e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 1.17e-03 8.29e-03 0.28800 -0.271000 0.098300 5.34e-02 4.83e-01
CYTOPROTECTION BY HMOX1 119 1.80e-04 2.03e-03 0.28700 -0.216000 -0.189000 4.84e-05 3.62e-04
SIGNALING BY THE B CELL RECEPTOR BCR 104 3.32e-04 3.22e-03 0.28600 -0.227000 -0.174000 6.38e-05 2.16e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 34 4.10e-02 1.27e-01 0.28600 -0.246000 -0.147000 1.32e-02 1.39e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 3.84e-04 3.62e-03 0.28600 -0.282000 0.046200 1.68e-02 6.95e-01
PI 3K CASCADE FGFR2 17 2.33e-01 4.11e-01 0.28600 -0.158000 -0.238000 2.59e-01 8.96e-02
ION TRANSPORT BY P TYPE ATPASES 49 3.03e-02 1.02e-01 0.28500 0.213000 0.189000 9.93e-03 2.20e-02
HIV INFECTION 222 4.69e-08 1.72e-06 0.28500 -0.226000 -0.173000 6.47e-09 9.27e-06
MITOPHAGY 29 5.10e-02 1.49e-01 0.28400 -0.251000 -0.134000 1.94e-02 2.13e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 2.31e-02 8.32e-02 0.28400 -0.252000 -0.131000 8.88e-03 1.74e-01
NCAM1 INTERACTIONS 40 3.70e-02 1.19e-01 0.28400 0.234000 0.161000 1.04e-02 7.87e-02
G0 AND EARLY G1 25 1.77e-01 3.38e-01 0.28300 -0.199000 -0.202000 8.54e-02 8.05e-02
RND3 GTPASE CYCLE 38 4.83e-02 1.44e-01 0.28300 0.163000 0.231000 8.15e-02 1.39e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.78e-01 3.40e-01 0.28200 -0.268000 -0.090300 1.09e-01 5.88e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.40e-02 5.58e-02 0.28100 -0.281000 0.007520 5.20e-02 9.58e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 2.91e-02 9.94e-02 0.28100 -0.275000 -0.053100 3.76e-02 6.89e-01
MAPK6 MAPK4 SIGNALING 85 1.97e-03 1.27e-02 0.28100 -0.221000 -0.173000 4.29e-04 5.94e-03
CELLULAR RESPONSE TO CHEMICAL STRESS 152 1.75e-05 3.27e-04 0.28000 -0.219000 -0.175000 3.17e-06 1.98e-04
TCR SIGNALING 102 1.01e-03 7.44e-03 0.28000 -0.202000 -0.194000 4.28e-04 7.10e-04
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 96 7.52e-10 5.18e-08 0.27900 -0.278000 -0.026000 2.48e-06 6.61e-01
DISEASES OF MITOTIC CELL CYCLE 37 7.53e-02 1.91e-01 0.27900 -0.213000 -0.180000 2.47e-02 5.83e-02
LAGGING STRAND SYNTHESIS 20 8.36e-02 2.05e-01 0.27900 -0.259000 -0.105000 4.52e-02 4.19e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.48e-01 3.00e-01 0.27900 -0.158000 -0.230000 1.81e-01 5.13e-02
CHONDROITIN SULFATE BIOSYNTHESIS 18 3.01e-01 4.86e-01 0.27800 0.197000 0.196000 1.47e-01 1.51e-01
SIGNALING BY NOTCH2 33 5.68e-03 2.83e-02 0.27700 0.072900 0.267000 4.69e-01 7.86e-03
RUNX2 REGULATES BONE DEVELOPMENT 29 1.46e-01 2.97e-01 0.27700 0.190000 0.201000 7.68e-02 6.05e-02
POLYMERASE SWITCHING 14 1.19e-01 2.55e-01 0.27700 -0.266000 -0.076400 8.49e-02 6.21e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 3.58e-03 2.06e-02 0.27600 -0.239000 -0.139000 1.05e-03 5.58e-02
PEXOPHAGY 11 3.51e-01 5.38e-01 0.27500 0.131000 0.242000 4.52e-01 1.64e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 1.92e-02 7.28e-02 0.27500 -0.029500 -0.274000 8.24e-01 3.89e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 4.49e-01 6.41e-01 0.27500 0.230000 0.151000 2.08e-01 4.07e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 2.83e-04 2.84e-03 0.27500 -0.204000 -0.184000 8.54e-05 4.13e-04
FRS MEDIATED FGFR2 SIGNALING 19 2.10e-01 3.82e-01 0.27500 -0.147000 -0.232000 2.66e-01 8.03e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 1.61e-03 1.07e-02 0.27500 -0.233000 -0.145000 4.03e-04 2.78e-02
APOPTOTIC FACTOR MEDIATED RESPONSE 18 3.07e-01 4.92e-01 0.27500 -0.200000 -0.188000 1.42e-01 1.67e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 2.62e-01 4.45e-01 0.27500 0.101000 0.255000 5.60e-01 1.43e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 5.33e-03 2.69e-02 0.27400 0.169000 0.216000 1.14e-02 1.25e-03
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.98e-02 7.43e-02 0.27400 -0.236000 -0.139000 6.17e-03 1.07e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 4.42e-04 3.94e-03 0.27400 -0.240000 -0.131000 1.54e-04 3.92e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.43e-01 4.23e-01 0.27300 -0.261000 -0.080900 1.54e-01 6.58e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 7.01e-02 1.82e-01 0.27300 0.258000 0.088400 4.59e-02 4.94e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 4.04e-01 5.98e-01 0.27300 0.186000 0.200000 2.29e-01 1.96e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 4.80e-01 6.65e-01 0.27200 0.221000 0.159000 2.26e-01 3.84e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 9.58e-02 2.23e-01 0.27200 0.021600 0.271000 9.01e-01 1.19e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 5.45e-02 1.56e-01 0.27200 0.149000 0.228000 1.16e-01 1.66e-02
REGULATED NECROSIS 46 8.46e-03 3.78e-02 0.27200 -0.246000 -0.117000 3.92e-03 1.71e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 36 8.50e-02 2.07e-01 0.27200 -0.213000 -0.169000 2.69e-02 7.95e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 6.22e-02 1.71e-01 0.27000 -0.252000 -0.096600 3.64e-02 4.23e-01
THE NLRP3 INFLAMMASOME 14 3.43e-01 5.29e-01 0.26900 -0.225000 -0.148000 1.46e-01 3.36e-01
RHOA GTPASE CYCLE 143 1.38e-04 1.64e-03 0.26900 0.191000 0.189000 8.05e-05 9.30e-05
REPRESSION OF WNT TARGET GENES 14 7.22e-02 1.85e-01 0.26900 0.037600 0.266000 8.07e-01 8.43e-02
VOLTAGE GATED POTASSIUM CHANNELS 39 8.80e-03 3.89e-02 0.26800 0.251000 0.093600 6.63e-03 3.12e-01
ERKS ARE INACTIVATED 13 2.79e-01 4.62e-01 0.26800 -0.241000 -0.118000 1.33e-01 4.62e-01
EUKARYOTIC TRANSLATION ELONGATION 88 1.08e-09 6.34e-08 0.26700 -0.267000 0.002200 1.47e-05 9.72e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 2.34e-01 4.11e-01 0.26700 0.209000 0.166000 8.97e-02 1.77e-01
HDMS DEMETHYLATE HISTONES 26 1.04e-01 2.36e-01 0.26700 0.130000 0.233000 2.51e-01 3.97e-02
DUAL INCISION IN TC NER 64 2.67e-03 1.63e-02 0.26700 -0.237000 -0.123000 1.04e-03 9.00e-02
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 7.57e-03 3.51e-02 0.26700 -0.205000 -0.170000 1.97e-03 1.03e-02
TRAFFICKING OF AMPA RECEPTORS 31 1.46e-01 2.97e-01 0.26700 0.180000 0.197000 8.34e-02 5.77e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 4.73e-01 6.58e-01 0.26600 0.177000 0.199000 2.88e-01 2.33e-01
MUCOPOLYSACCHARIDOSES 11 4.65e-01 6.51e-01 0.26600 0.156000 0.215000 3.71e-01 2.16e-01
COHESIN LOADING ONTO CHROMATIN 10 3.42e-01 5.29e-01 0.26600 -0.105000 -0.244000 5.64e-01 1.81e-01
ANCHORING FIBRIL FORMATION 14 8.64e-03 3.85e-02 0.26600 0.249000 -0.091700 1.06e-01 5.53e-01
PEROXISOMAL PROTEIN IMPORT 58 7.39e-03 3.46e-02 0.26500 -0.231000 -0.130000 2.37e-03 8.61e-02
DCC MEDIATED ATTRACTIVE SIGNALING 14 2.62e-01 4.45e-01 0.26500 0.117000 0.238000 4.49e-01 1.24e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 2.66e-01 4.50e-01 0.26400 -0.241000 -0.109000 1.33e-01 4.96e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 2.39e-01 4.18e-01 0.26400 -0.226000 -0.136000 9.68e-02 3.17e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 69 7.59e-03 3.51e-02 0.26400 -0.150000 -0.217000 3.12e-02 1.82e-03
G1 S SPECIFIC TRANSCRIPTION 27 1.91e-01 3.57e-01 0.26300 -0.172000 -0.199000 1.23e-01 7.37e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 165 4.28e-09 2.02e-07 0.26300 -0.246000 -0.090600 4.78e-08 4.49e-02
TNFR2 NON CANONICAL NF KB PATHWAY 82 5.54e-04 4.74e-03 0.26100 -0.234000 -0.116000 2.58e-04 6.95e-02
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 7.64e-02 1.92e-01 0.26100 -0.260000 0.010300 1.35e-01 9.53e-01
SIGNALING BY NOTCH1 75 1.72e-03 1.12e-02 0.26000 0.124000 0.229000 6.43e-02 6.06e-04
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 3.14e-02 1.05e-01 0.25800 -0.250000 -0.065700 3.07e-02 5.69e-01
RET SIGNALING 36 1.11e-01 2.45e-01 0.25700 0.160000 0.201000 9.70e-02 3.67e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 1.40e-03 9.46e-03 0.25400 -0.076400 0.242000 5.35e-01 4.91e-02
EFFECTS OF PIP2 HYDROLYSIS 27 1.36e-01 2.83e-01 0.25400 0.218000 0.131000 5.01e-02 2.39e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 4.60e-01 6.49e-01 0.25200 0.185000 0.172000 2.31e-01 2.66e-01
FERTILIZATION 13 2.48e-01 4.30e-01 0.25200 0.236000 0.088300 1.40e-01 5.81e-01
NEUROTRANSMITTER RELEASE CYCLE 49 4.58e-02 1.39e-01 0.25200 0.146000 0.205000 7.65e-02 1.31e-02
ERK MAPK TARGETS 22 2.45e-01 4.25e-01 0.25100 -0.206000 -0.144000 9.39e-02 2.44e-01
SHC MEDIATED CASCADE FGFR1 16 3.90e-01 5.80e-01 0.25100 -0.198000 -0.155000 1.71e-01 2.84e-01
REGULATION OF INSULIN SECRETION 71 1.17e-03 8.29e-03 0.25100 0.099600 0.230000 1.47e-01 7.92e-04
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 1.15e-02 4.81e-02 0.25000 0.084200 0.236000 3.51e-01 9.00e-03
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 3.08e-01 4.92e-01 0.25000 0.085900 0.235000 6.22e-01 1.77e-01
RMTS METHYLATE HISTONE ARGININES 42 4.86e-02 1.44e-01 0.25000 0.127000 0.215000 1.53e-01 1.61e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 6.38e-02 1.72e-01 0.24900 -0.237000 -0.077000 4.45e-02 5.14e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 1.61e-01 3.14e-01 0.24900 0.155000 0.195000 1.30e-01 5.68e-02
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 3.92e-01 5.82e-01 0.24800 0.117000 0.219000 4.83e-01 1.89e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 3.83e-02 1.22e-01 0.24800 0.187000 0.164000 1.24e-02 2.84e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.46e-01 2.97e-01 0.24800 -0.240000 -0.062700 1.08e-01 6.74e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 4.65e-02 1.40e-01 0.24800 -0.138000 -0.206000 9.76e-02 1.36e-02
ENOS ACTIVATION 11 2.01e-01 3.69e-01 0.24800 -0.243000 -0.046000 1.62e-01 7.92e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 5.30e-01 7.09e-01 0.24700 0.173000 0.176000 2.99e-01 2.90e-01
DAG AND IP3 SIGNALING 40 1.12e-01 2.46e-01 0.24700 0.189000 0.159000 3.88e-02 8.11e-02
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 21 2.89e-02 9.91e-02 0.24700 -0.246000 -0.025300 5.13e-02 8.41e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 1.53e-01 3.05e-01 0.24700 -0.238000 -0.063800 1.10e-01 6.69e-01
SELENOAMINO ACID METABOLISM 110 6.02e-09 2.60e-07 0.24600 -0.246000 -0.021100 8.71e-06 7.02e-01
TNF SIGNALING 43 4.00e-02 1.26e-01 0.24600 0.119000 0.216000 1.79e-01 1.44e-02
CELLULAR RESPONSE TO STARVATION 147 7.93e-10 5.18e-08 0.24600 -0.242000 -0.046200 4.37e-07 3.34e-01
PEROXISOMAL LIPID METABOLISM 26 2.49e-01 4.30e-01 0.24600 -0.185000 -0.162000 1.02e-01 1.54e-01
INOSITOL PHOSPHATE METABOLISM 46 6.35e-02 1.72e-01 0.24600 0.200000 0.143000 1.89e-02 9.45e-02
INTEGRATION OF ENERGY METABOLISM 99 4.25e-04 3.84e-03 0.24600 0.113000 0.218000 5.32e-02 1.77e-04
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 1.70e-02 6.57e-02 0.24500 -0.233000 -0.076700 1.43e-02 4.20e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 2.95e-02 1.00e-01 0.24400 -0.147000 -0.195000 4.59e-02 7.97e-03
INTERFERON GAMMA SIGNALING 78 3.93e-09 1.93e-07 0.24400 -0.239000 0.048400 2.64e-04 4.60e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 4.63e-01 6.51e-01 0.24400 -0.174000 -0.171000 2.44e-01 2.52e-01
INTEGRIN SIGNALING 24 2.34e-01 4.11e-01 0.24300 0.138000 0.201000 2.42e-01 8.88e-02
RA BIOSYNTHESIS PATHWAY 14 4.53e-01 6.44e-01 0.24300 -0.147000 -0.194000 3.42e-01 2.08e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.10e-01 4.95e-01 0.24300 -0.175000 -0.168000 1.47e-01 1.62e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 5.01e-01 6.83e-01 0.24200 0.122000 0.209000 5.06e-01 2.51e-01
INTERLEUKIN 1 SIGNALING 96 5.24e-03 2.66e-02 0.24200 -0.191000 -0.148000 1.21e-03 1.23e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 9.40e-02 2.21e-01 0.24100 -0.237000 -0.044500 9.04e-02 7.51e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 4.27e-04 3.84e-03 0.24100 -0.146000 0.192000 2.16e-01 1.03e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 2.50e-02 8.87e-02 0.24100 -0.199000 -0.136000 6.75e-03 6.41e-02
RHO GTPASES ACTIVATE NADPH OXIDASES 22 2.22e-01 3.96e-01 0.24000 -0.120000 -0.208000 3.31e-01 9.10e-02
NUCLEOTIDE EXCISION REPAIR 109 4.55e-04 4.00e-03 0.24000 -0.210000 -0.116000 1.51e-04 3.62e-02
SIALIC ACID METABOLISM 32 1.90e-01 3.57e-01 0.24000 -0.184000 -0.154000 7.16e-02 1.32e-01
MITOTIC SPINDLE CHECKPOINT 96 8.11e-03 3.67e-02 0.24000 -0.160000 -0.178000 6.60e-03 2.59e-03
RHOV GTPASE CYCLE 33 1.54e-01 3.06e-01 0.24000 0.140000 0.195000 1.65e-01 5.31e-02
PRE NOTCH EXPRESSION AND PROCESSING 62 2.79e-02 9.65e-02 0.23900 0.136000 0.196000 6.46e-02 7.58e-03
RHOU GTPASE CYCLE 34 1.50e-01 3.02e-01 0.23800 0.139000 0.193000 1.60e-01 5.14e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.78e-01 4.61e-01 0.23800 0.118000 0.206000 3.72e-01 1.19e-01
TRANSCRIPTION OF THE HIV GENOME 67 2.73e-02 9.45e-02 0.23800 -0.190000 -0.143000 7.30e-03 4.27e-02
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 7.48e-03 3.49e-02 0.23800 0.097000 0.217000 1.98e-01 3.96e-03
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 4.14e-01 6.08e-01 0.23700 0.173000 0.162000 2.03e-01 2.34e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 1.21e-01 2.57e-01 0.23700 -0.216000 -0.098700 5.70e-02 3.84e-01
GLYCOGEN SYNTHESIS 14 3.82e-01 5.71e-01 0.23700 -0.207000 -0.115000 1.80e-01 4.56e-01
SIGNALING BY NOTCH4 83 4.16e-04 3.82e-03 0.23700 -0.222000 -0.083500 4.82e-04 1.89e-01
ABC TRANSPORTER DISORDERS 70 1.77e-02 6.81e-02 0.23700 -0.196000 -0.133000 4.64e-03 5.47e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 1.33e-01 2.79e-01 0.23600 0.177000 0.156000 4.98e-02 8.39e-02
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 9.50e-02 2.22e-01 0.23600 -0.118000 -0.204000 2.19e-01 3.44e-02
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 1.59e-01 3.13e-01 0.23500 -0.218000 -0.089100 8.40e-02 4.80e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 3.66e-01 5.55e-01 0.23500 0.149000 0.182000 2.49e-01 1.59e-01
EPHRIN SIGNALING 19 4.52e-02 1.37e-01 0.23300 0.012700 0.233000 9.24e-01 7.87e-02
CA2 PATHWAY 58 7.32e-04 5.78e-03 0.23300 0.047800 0.228000 5.29e-01 2.65e-03
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 64 4.53e-03 2.47e-02 0.23300 -0.215000 -0.089400 2.95e-03 2.16e-01
GLYCOSPHINGOLIPID METABOLISM 38 1.57e-01 3.11e-01 0.23300 -0.150000 -0.178000 1.11e-01 5.73e-02
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.51e-01 5.38e-01 0.23200 -0.199000 -0.120000 1.55e-01 3.92e-01
CHROMOSOME MAINTENANCE 100 5.25e-03 2.66e-02 0.23100 -0.188000 -0.136000 1.20e-03 1.92e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 4.25e-01 6.18e-01 0.23100 -0.207000 -0.104000 2.16e-01 5.32e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 19 2.94e-01 4.79e-01 0.23100 -0.201000 -0.114000 1.29e-01 3.92e-01
ONCOGENE INDUCED SENESCENCE 32 1.86e-01 3.52e-01 0.23100 0.135000 0.187000 1.86e-01 6.68e-02
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 7.89e-04 6.02e-03 0.23000 -0.091500 0.211000 4.11e-01 5.75e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 6.44e-02 1.73e-01 0.23000 0.165000 0.160000 2.69e-02 3.19e-02
RAF ACTIVATION 34 1.70e-01 3.29e-01 0.23000 -0.186000 -0.134000 5.99e-02 1.75e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 4.48e-01 6.41e-01 0.23000 -0.149000 -0.175000 2.89e-01 2.12e-01
TRIGLYCERIDE METABOLISM 24 5.95e-02 1.65e-01 0.23000 -0.224000 -0.050300 5.75e-02 6.69e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 5.51e-01 7.28e-01 0.22900 -0.170000 -0.153000 2.88e-01 3.41e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 87 1.98e-02 7.43e-02 0.22800 0.166000 0.156000 7.39e-03 1.17e-02
FATTY ACYL COA BIOSYNTHESIS 32 1.95e-01 3.62e-01 0.22800 -0.185000 -0.134000 7.05e-02 1.90e-01
SYNTHESIS OF PA 29 2.24e-01 3.99e-01 0.22800 0.186000 0.132000 8.37e-02 2.19e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 8.79e-02 2.11e-01 0.22700 -0.217000 -0.068200 6.07e-02 5.55e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 1.73e-01 3.32e-01 0.22700 -0.227000 0.006940 2.14e-01 9.70e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 5.16e-03 2.66e-02 0.22600 -0.060700 0.217000 6.14e-01 7.10e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES 319 1.16e-12 2.27e-10 0.22600 -0.212000 -0.076900 7.97e-11 1.84e-02
ANTIMICROBIAL PEPTIDES 17 4.31e-01 6.24e-01 0.22500 -0.182000 -0.133000 1.95e-01 3.41e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 2.02e-02 7.46e-02 0.22500 0.032700 0.223000 7.57e-01 3.48e-02
G PROTEIN MEDIATED EVENTS 51 1.08e-01 2.42e-01 0.22500 0.159000 0.159000 4.93e-02 4.94e-02
RESOLUTION OF SISTER CHROMATID COHESION 101 8.00e-03 3.65e-02 0.22400 -0.135000 -0.179000 1.91e-02 1.89e-03
FATTY ACID METABOLISM 146 3.50e-04 3.37e-03 0.22400 -0.189000 -0.120000 7.92e-05 1.23e-02
MTORC1 MEDIATED SIGNALLING 24 2.73e-01 4.56e-01 0.22400 -0.188000 -0.121000 1.11e-01 3.05e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 2.62e-02 9.14e-02 0.22300 0.167000 -0.148000 2.98e-01 3.55e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 1.44e-01 2.95e-01 0.22300 0.135000 0.178000 1.35e-01 4.90e-02
PROGRAMMED CELL DEATH 188 4.68e-05 6.97e-04 0.22300 -0.187000 -0.121000 9.56e-06 4.31e-03
IRAK4 DEFICIENCY TLR2 4 15 4.85e-01 6.68e-01 0.22300 -0.132000 -0.179000 3.76e-01 2.29e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 49 1.86e-02 7.10e-02 0.22200 0.080200 0.207000 3.31e-01 1.20e-02
UCH PROTEINASES 90 7.04e-03 3.35e-02 0.22200 -0.189000 -0.117000 1.92e-03 5.56e-02
NEDDYLATION 220 8.17e-05 1.02e-03 0.22200 -0.166000 -0.148000 2.38e-05 1.62e-04
CELLULAR HEXOSE TRANSPORT 11 3.00e-01 4.85e-01 0.22200 0.049100 0.216000 7.78e-01 2.14e-01
PKMTS METHYLATE HISTONE LYSINES 47 1.13e-01 2.47e-01 0.22200 0.176000 0.135000 3.68e-02 1.10e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 2.49e-01 4.30e-01 0.22200 -0.172000 -0.140000 9.79e-02 1.77e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 4.18e-01 6.12e-01 0.22200 -0.167000 -0.146000 1.96e-01 2.60e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 2.94e-02 1.00e-01 0.22200 0.088800 0.203000 2.88e-01 1.50e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 2.86e-01 4.71e-01 0.22100 -0.082600 -0.205000 5.67e-01 1.55e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 5.70e-01 7.38e-01 0.22100 -0.146000 -0.166000 3.63e-01 2.99e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 3.08e-01 4.92e-01 0.22100 0.137000 0.173000 2.27e-01 1.26e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 5.61e-01 7.35e-01 0.22000 0.171000 0.138000 2.85e-01 3.88e-01
BILE ACID AND BILE SALT METABOLISM 24 3.96e-02 1.25e-01 0.22000 0.219000 0.021700 6.36e-02 8.54e-01
INFLUENZA INFECTION 146 3.55e-07 9.94e-06 0.22000 -0.213000 -0.053800 8.88e-06 2.62e-01
NICOTINAMIDE SALVAGING 15 2.29e-01 4.06e-01 0.22000 -0.212000 -0.057900 1.56e-01 6.98e-01
RAC1 GTPASE CYCLE 179 3.75e-04 3.59e-03 0.21900 0.172000 0.136000 7.54e-05 1.76e-03
MITOTIC G2 G2 M PHASES 186 7.43e-05 9.49e-04 0.21800 -0.117000 -0.184000 6.08e-03 1.59e-05
DISEASES OF PROGRAMMED CELL DEATH 53 1.39e-02 5.55e-02 0.21800 -0.204000 -0.075100 1.01e-02 3.45e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 5.55e-01 7.31e-01 0.21700 0.130000 0.174000 4.16e-01 2.78e-01
MISMATCH REPAIR 14 1.73e-01 3.32e-01 0.21700 -0.215000 -0.026900 1.63e-01 8.62e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 2.79e-01 4.62e-01 0.21700 0.185000 0.113000 1.16e-01 3.40e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 5.60e-03 2.81e-02 0.21700 -0.126000 0.177000 3.30e-01 1.72e-01
HSF1 ACTIVATION 26 3.39e-01 5.25e-01 0.21700 -0.142000 -0.164000 2.10e-01 1.49e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 4.39e-01 6.35e-01 0.21600 0.175000 0.128000 2.00e-01 3.48e-01
OLFACTORY SIGNALING PATHWAY 31 1.22e-01 2.60e-01 0.21600 0.197000 0.089700 5.79e-02 3.88e-01
M PHASE 339 1.48e-06 3.42e-05 0.21600 -0.152000 -0.154000 1.60e-06 1.23e-06
RRNA PROCESSING 195 2.37e-07 7.34e-06 0.21600 -0.202000 -0.074700 1.15e-06 7.23e-02
SYNTHESIS OF PE 13 5.92e-01 7.52e-01 0.21500 0.158000 0.146000 3.25e-01 3.61e-01
PYRIMIDINE CATABOLISM 10 3.63e-01 5.52e-01 0.21500 -0.049200 -0.209000 7.88e-01 2.52e-01
NONSENSE MEDIATED DECAY NMD 110 9.60e-08 3.23e-06 0.21500 -0.215000 -0.002390 1.01e-04 9.65e-01
FCERI MEDIATED MAPK ACTIVATION 28 1.92e-01 3.58e-01 0.21500 -0.190000 -0.100000 8.21e-02 3.60e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 2.62e-01 4.45e-01 0.21400 -0.119000 -0.178000 2.75e-01 1.03e-01
SENSORY PROCESSING OF SOUND 61 8.03e-02 2.00e-01 0.21400 0.165000 0.137000 2.61e-02 6.50e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 6.72e-02 1.78e-01 0.21400 -0.205000 0.060400 2.01e-01 7.06e-01
TELOMERE MAINTENANCE 77 1.28e-02 5.26e-02 0.21400 -0.187000 -0.102000 4.47e-03 1.21e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 5.24e-02 1.52e-01 0.21300 -0.083700 0.196000 6.01e-01 2.20e-01
RHO GTPASES ACTIVATE KTN1 11 6.33e-01 7.83e-01 0.21300 -0.166000 -0.134000 3.42e-01 4.42e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 1.48e-01 3.00e-01 0.21300 -0.204000 -0.062200 9.83e-02 6.13e-01
HIV LIFE CYCLE 142 2.54e-03 1.58e-02 0.21300 -0.168000 -0.130000 5.60e-04 7.38e-03
TRNA PROCESSING IN THE NUCLEUS 56 1.10e-01 2.44e-01 0.21200 -0.142000 -0.158000 6.61e-02 4.10e-02
COLLAGEN CHAIN TRIMERIZATION 41 5.53e-05 7.74e-04 0.21200 0.106000 -0.184000 2.42e-01 4.16e-02
METABOLISM OF STEROID HORMONES 21 3.69e-01 5.58e-01 0.21200 -0.116000 -0.177000 3.56e-01 1.61e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.93e-01 3.60e-01 0.21200 -0.142000 -0.157000 1.11e-01 7.86e-02
G ALPHA S SIGNALLING EVENTS 108 6.37e-04 5.30e-03 0.21100 0.082600 0.194000 1.38e-01 4.83e-04
TRAF6 MEDIATED IRF7 ACTIVATION 15 7.92e-02 1.98e-01 0.21100 -0.023800 0.210000 8.73e-01 1.59e-01
CHROMATIN MODIFYING ENZYMES 219 2.40e-04 2.55e-03 0.21100 0.147000 0.151000 1.84e-04 1.15e-04
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 1.15e-01 2.50e-01 0.21100 0.142000 0.156000 6.67e-02 4.39e-02
COPII MEDIATED VESICLE TRANSPORT 66 8.40e-03 3.77e-02 0.21000 -0.196000 -0.075800 5.93e-03 2.87e-01
RHOBTB2 GTPASE CYCLE 23 4.20e-01 6.13e-01 0.20900 -0.147000 -0.149000 2.23e-01 2.16e-01
SARS COV 1 INFECTION 48 3.66e-02 1.18e-01 0.20900 -0.193000 -0.078900 2.05e-02 3.45e-01
DUAL INCISION IN GG NER 40 4.89e-02 1.45e-01 0.20800 -0.196000 -0.070200 3.17e-02 4.43e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 5.20e-01 7.00e-01 0.20800 -0.165000 -0.127000 2.54e-01 3.78e-01
CELL CYCLE MITOTIC 473 2.31e-08 8.76e-07 0.20800 -0.156000 -0.138000 6.93e-09 3.12e-07
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 4.08e-03 2.27e-02 0.20800 -0.067400 0.197000 5.44e-01 7.72e-02
SEMAPHORIN INTERACTIONS 64 4.94e-02 1.46e-01 0.20800 0.175000 0.111000 1.53e-02 1.25e-01
PCP CE PATHWAY 90 1.14e-02 4.78e-02 0.20700 -0.179000 -0.106000 3.41e-03 8.36e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 6.72e-02 1.78e-01 0.20700 0.148000 0.146000 2.93e-02 3.16e-02
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 53 1.15e-01 2.50e-01 0.20700 0.125000 0.165000 1.16e-01 3.76e-02
APOPTOSIS 166 4.95e-04 4.28e-03 0.20700 -0.174000 -0.112000 1.11e-04 1.30e-02
SIGNALING BY INSULIN RECEPTOR 64 9.03e-02 2.16e-01 0.20700 -0.155000 -0.137000 3.24e-02 5.76e-02
DISEASES OF GLYCOSYLATION 124 8.80e-03 3.89e-02 0.20700 0.158000 0.133000 2.36e-03 1.08e-02
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 4.68e-01 6.55e-01 0.20600 0.195000 0.067300 2.85e-01 7.13e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 14 8.55e-02 2.07e-01 0.20500 -0.201000 0.040100 1.92e-01 7.95e-01
G PROTEIN BETA GAMMA SIGNALLING 31 5.23e-03 2.66e-02 0.20500 -0.202000 0.033700 5.12e-02 7.46e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.90e-01 3.57e-01 0.20500 -0.131000 -0.157000 1.32e-01 7.16e-02
SPHINGOLIPID METABOLISM 79 5.63e-02 1.59e-01 0.20400 -0.151000 -0.138000 2.02e-02 3.46e-02
GAP JUNCTION ASSEMBLY 21 4.71e-01 6.57e-01 0.20400 -0.142000 -0.146000 2.61e-01 2.47e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 7.40e-02 1.89e-01 0.20300 -0.165000 -0.119000 2.25e-02 1.00e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 2.95e-01 4.81e-01 0.20300 0.127000 0.159000 2.15e-01 1.20e-01
MITOTIC PROPHASE 93 1.20e-03 8.40e-03 0.20300 -0.192000 -0.067400 1.40e-03 2.62e-01
DNA DAMAGE RECOGNITION IN GG NER 38 9.52e-02 2.22e-01 0.20300 -0.186000 -0.080800 4.73e-02 3.89e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 4.04e-01 5.98e-01 0.20300 0.177000 0.098200 1.93e-01 4.71e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 1.90e-01 3.57e-01 0.20300 0.087200 0.183000 4.16e-01 8.83e-02
FLT3 SIGNALING IN DISEASE 28 3.68e-01 5.57e-01 0.20200 0.149000 0.136000 1.71e-01 2.13e-01
COSTIMULATION BY THE CD28 FAMILY 50 5.74e-02 1.60e-01 0.20100 -0.182000 -0.085500 2.60e-02 2.96e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.14e-01 2.49e-01 0.20100 -0.011300 -0.201000 9.34e-01 1.40e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 6.69e-01 8.15e-01 0.20100 -0.155000 -0.129000 3.75e-01 4.60e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 4.10e-01 6.05e-01 0.20100 -0.092800 -0.178000 5.08e-01 2.03e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 1.47e-01 2.98e-01 0.20100 0.195000 -0.046500 2.62e-01 7.89e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 3.35e-01 5.21e-01 0.20000 -0.199000 -0.022600 2.76e-01 9.02e-01
SIGNAL AMPLIFICATION 30 1.45e-03 9.77e-03 0.20000 -0.108000 0.168000 3.04e-01 1.10e-01
BIOLOGICAL OXIDATIONS 125 2.47e-03 1.55e-02 0.20000 -0.174000 -0.098100 7.80e-04 5.85e-02
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 1.88e-01 3.56e-01 0.20000 -0.050300 -0.193000 6.97e-01 1.34e-01
RESOLUTION OF D LOOP STRUCTURES 30 6.34e-02 1.72e-01 0.19900 -0.040100 -0.195000 7.04e-01 6.40e-02
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 1.29e-01 2.72e-01 0.19900 -0.062000 -0.189000 5.70e-01 8.28e-02
PLASMA LIPOPROTEIN REMODELING 13 2.74e-01 4.56e-01 0.19900 0.031500 0.197000 8.44e-01 2.20e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 16 5.78e-01 7.42e-01 0.19900 -0.139000 -0.143000 3.37e-01 3.24e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 25 1.36e-01 2.83e-01 0.19900 0.052900 0.191000 6.47e-01 9.76e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 6.25e-01 7.79e-01 0.19900 0.154000 0.125000 3.35e-01 4.36e-01
PROLONGED ERK ACTIVATION EVENTS 14 6.08e-01 7.68e-01 0.19800 -0.126000 -0.153000 4.14e-01 3.23e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 2.14e-01 3.87e-01 0.19800 -0.050500 -0.191000 7.03e-01 1.49e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 5.62e-01 7.35e-01 0.19700 0.095100 0.173000 5.68e-01 3.00e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 5.46e-01 7.24e-01 0.19700 -0.138000 -0.141000 3.12e-01 3.00e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 20 5.56e-02 1.59e-01 0.19600 -0.195000 0.020300 1.30e-01 8.75e-01
HOMOLOGY DIRECTED REPAIR 105 1.47e-02 5.80e-02 0.19600 -0.109000 -0.163000 5.43e-02 3.86e-03
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 5.68e-01 7.38e-01 0.19500 -0.132000 -0.144000 3.47e-01 3.05e-01
NONHOMOLOGOUS END JOINING NHEJ 42 2.26e-01 4.01e-01 0.19500 -0.119000 -0.154000 1.80e-01 8.51e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 2.00e-01 3.69e-01 0.19400 0.070300 0.181000 5.35e-01 1.10e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 110 1.66e-02 6.44e-02 0.19400 -0.158000 -0.113000 4.23e-03 4.12e-02
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 2.21e-03 1.41e-02 0.19400 -0.124000 0.149000 2.49e-01 1.64e-01
CELL CYCLE 590 8.42e-09 3.30e-07 0.19400 -0.139000 -0.135000 8.45e-09 2.27e-08
MITOTIC TELOPHASE CYTOKINESIS 13 1.83e-01 3.47e-01 0.19400 0.008810 -0.194000 9.56e-01 2.26e-01
SIGNALING BY ROBO RECEPTORS 210 6.05e-08 2.16e-06 0.19400 -0.188000 -0.047200 2.68e-06 2.39e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 5.99e-02 1.65e-01 0.19400 0.193000 -0.012800 1.25e-01 9.19e-01
LAMININ INTERACTIONS 28 1.49e-01 3.01e-01 0.19300 0.183000 0.061200 9.29e-02 5.75e-01
GABA B RECEPTOR ACTIVATION 40 2.01e-02 7.45e-02 0.19300 0.025900 0.192000 7.77e-01 3.61e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 2.34e-01 4.11e-01 0.19300 -0.180000 -0.070800 1.28e-01 5.48e-01
PECAM1 INTERACTIONS 12 5.52e-01 7.29e-01 0.19300 0.087000 0.172000 6.02e-01 3.02e-01
INTERFERON SIGNALING 166 2.08e-11 2.22e-09 0.19300 -0.190000 0.031100 2.37e-05 4.90e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 1.24e-01 2.62e-01 0.19200 -0.159000 -0.108000 4.15e-02 1.66e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 1.42e-01 2.92e-01 0.19200 -0.167000 0.094700 3.62e-01 6.04e-01
PI 3K CASCADE FGFR1 16 5.80e-01 7.43e-01 0.19100 -0.150000 -0.118000 2.98e-01 4.12e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 3.58e-03 2.06e-02 0.19100 -0.187000 -0.040000 7.74e-03 5.68e-01
REGULATION OF KIT SIGNALING 16 3.76e-01 5.65e-01 0.19000 0.065700 0.178000 6.49e-01 2.18e-01
AMINO ACIDS REGULATE MTORC1 51 8.34e-02 2.05e-01 0.18900 -0.170000 -0.083600 3.58e-02 3.02e-01
ARACHIDONIC ACID METABOLISM 40 7.62e-02 1.92e-01 0.18900 -0.179000 -0.060800 4.99e-02 5.06e-01
TP53 REGULATES METABOLIC GENES 87 6.65e-02 1.77e-01 0.18900 -0.127000 -0.140000 4.09e-02 2.39e-02
TRAF6 MEDIATED NF KB ACTIVATION 22 1.03e-01 2.35e-01 0.18900 0.013800 0.188000 9.11e-01 1.27e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 4.04e-02 1.26e-01 0.18900 -0.150000 -0.114000 1.13e-02 5.57e-02
DNA METHYLATION 19 1.35e-01 2.81e-01 0.18800 -0.188000 -0.010400 1.57e-01 9.37e-01
FRS MEDIATED FGFR1 SIGNALING 18 5.73e-01 7.40e-01 0.18800 -0.140000 -0.125000 3.04e-01 3.57e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 1.57e-01 3.11e-01 0.18700 0.038000 0.183000 7.52e-01 1.28e-01
MET PROMOTES CELL MOTILITY 38 9.69e-02 2.24e-01 0.18700 0.176000 0.062000 5.99e-02 5.09e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.08e-01 3.80e-01 0.18700 0.032800 -0.184000 8.50e-01 2.91e-01
INITIAL TRIGGERING OF COMPLEMENT 13 5.15e-01 6.95e-01 0.18700 0.170000 0.076800 2.88e-01 6.32e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 1.24e-02 5.11e-02 0.18600 0.156000 0.101000 3.30e-03 5.70e-02
CD28 CO STIMULATION 31 3.02e-01 4.86e-01 0.18500 -0.158000 -0.096600 1.28e-01 3.52e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 4.92e-01 6.75e-01 0.18500 -0.055800 -0.177000 7.49e-01 3.11e-01
CHAPERONE MEDIATED AUTOPHAGY 21 3.32e-01 5.18e-01 0.18500 -0.170000 -0.072400 1.77e-01 5.66e-01
BASE EXCISION REPAIR 55 2.16e-02 7.85e-02 0.18500 -0.178000 -0.048200 2.23e-02 5.36e-01
MEIOTIC RECOMBINATION 36 1.96e-01 3.63e-01 0.18400 -0.165000 -0.082900 8.73e-02 3.90e-01
NUCLEOBASE BIOSYNTHESIS 15 3.54e-01 5.41e-01 0.18400 -0.178000 -0.048500 2.33e-01 7.45e-01
FLT3 SIGNALING 36 3.07e-01 4.92e-01 0.18300 0.108000 0.148000 2.61e-01 1.24e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 1.23e-02 5.05e-02 0.18300 -0.073800 -0.168000 2.32e-01 6.51e-03
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.18e-01 2.55e-01 0.18300 0.035300 0.180000 7.51e-01 1.06e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 2.74e-01 4.56e-01 0.18300 -0.152000 -0.102000 1.09e-01 2.83e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 5.77e-01 7.42e-01 0.18300 0.127000 0.131000 3.37e-01 3.22e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 5.68e-01 7.38e-01 0.18300 -0.162000 -0.084000 3.11e-01 6.00e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 5.02e-01 6.84e-01 0.18300 -0.167000 -0.074500 2.80e-01 6.30e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 6.46e-01 7.95e-01 0.18200 -0.104000 -0.150000 5.15e-01 3.51e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 2.13e-02 7.76e-02 0.18200 0.010500 0.182000 9.09e-01 4.94e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 2.37e-01 4.15e-01 0.18200 -0.152000 -0.099200 9.21e-02 2.72e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 4.23e-01 6.15e-01 0.18100 -0.176000 -0.041800 2.90e-01 8.02e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 2.71e-01 4.54e-01 0.18000 -0.157000 -0.088000 1.18e-01 3.82e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 7.04e-01 8.37e-01 0.18000 -0.146000 -0.106000 4.02e-01 5.43e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 64 1.09e-01 2.43e-01 0.18000 -0.098100 -0.151000 1.75e-01 3.65e-02
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 6.28e-02 1.71e-01 0.18000 0.092000 0.155000 1.71e-01 2.12e-02
METABOLISM OF RNA 646 1.30e-09 7.27e-08 0.18000 -0.148000 -0.103000 1.70e-10 9.21e-06
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 2.41e-01 4.20e-01 0.17900 -0.164000 -0.072700 1.21e-01 4.91e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 4.82e-01 6.67e-01 0.17900 -0.099900 -0.148000 4.18e-01 2.29e-01
INFLAMMASOMES 18 4.47e-01 6.41e-01 0.17800 -0.161000 -0.076000 2.37e-01 5.77e-01
DAP12 INTERACTIONS 30 6.92e-03 3.32e-02 0.17800 -0.157000 0.083800 1.37e-01 4.27e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 38 4.43e-03 2.42e-02 0.17800 -0.048800 0.171000 6.03e-01 6.83e-02
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 352 3.82e-05 5.84e-04 0.17800 -0.140000 -0.110000 6.84e-06 4.22e-04
METAL ION SLC TRANSPORTERS 25 3.67e-01 5.56e-01 0.17800 0.083500 0.157000 4.70e-01 1.75e-01
HDR THROUGH MMEJ ALT NHEJ 10 4.12e-01 6.06e-01 0.17800 -0.016500 -0.177000 9.28e-01 3.33e-01
RHO GTPASES ACTIVATE FORMINS 118 3.01e-02 1.02e-01 0.17700 -0.108000 -0.141000 4.32e-02 8.19e-03
L1CAM INTERACTIONS 107 5.34e-02 1.54e-01 0.17700 0.132000 0.118000 1.86e-02 3.46e-02
RHOBTB1 GTPASE CYCLE 23 2.91e-01 4.77e-01 0.17700 -0.060700 -0.166000 6.15e-01 1.68e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 2.10e-01 3.82e-01 0.17700 -0.163000 -0.068000 1.10e-01 5.06e-01
HDACS DEACETYLATE HISTONES 45 9.47e-02 2.22e-01 0.17700 0.062100 0.165000 4.71e-01 5.49e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 4.04e-01 5.98e-01 0.17600 0.092400 0.150000 4.15e-01 1.85e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 4.60e-01 6.49e-01 0.17500 0.129000 0.119000 2.29e-01 2.69e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 2.17e-01 3.92e-01 0.17500 0.133000 0.114000 8.58e-02 1.39e-01
SARS COV 2 INFECTION 65 2.55e-03 1.58e-02 0.17500 -0.175000 -0.009200 1.48e-02 8.98e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 1.22e-01 2.58e-01 0.17400 0.161000 -0.067100 2.97e-01 6.64e-01
NEURONAL SYSTEM 373 6.88e-05 9.02e-04 0.17400 0.123000 0.123000 4.61e-05 4.50e-05
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 70 3.35e-02 1.10e-01 0.17400 0.064100 0.161000 3.54e-01 1.96e-02
SHC1 EVENTS IN EGFR SIGNALING 11 6.01e-01 7.60e-01 0.17400 -0.160000 -0.067800 3.59e-01 6.97e-01
PRC2 METHYLATES HISTONES AND DNA 28 7.19e-02 1.85e-01 0.17300 -0.173000 -0.004640 1.12e-01 9.66e-01
CTLA4 INHIBITORY SIGNALING 20 4.55e-01 6.46e-01 0.17300 -0.154000 -0.079400 2.33e-01 5.39e-01
CROSSLINKING OF COLLAGEN FIBRILS 16 2.03e-01 3.72e-01 0.17300 0.173000 -0.002760 2.31e-01 9.85e-01
RHO GTPASES ACTIVATE IQGAPS 24 5.37e-01 7.15e-01 0.17300 -0.119000 -0.125000 3.13e-01 2.88e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 290 6.04e-04 5.08e-03 0.17300 -0.126000 -0.118000 2.18e-04 5.72e-04
DEADENYLATION OF MRNA 25 3.18e-01 5.02e-01 0.17300 -0.159000 -0.067300 1.69e-01 5.60e-01
MRNA SPLICING MINOR PATHWAY 52 2.58e-01 4.42e-01 0.17200 -0.129000 -0.115000 1.09e-01 1.53e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 603 1.54e-09 8.25e-08 0.17200 -0.149000 -0.086600 5.10e-10 2.95e-04
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 46 1.72e-01 3.32e-01 0.17100 -0.152000 -0.078800 7.40e-02 3.55e-01
EXTRACELLULAR MATRIX ORGANIZATION 247 1.58e-03 1.05e-02 0.17100 0.131000 0.110000 3.82e-04 2.94e-03
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 45 2.37e-02 8.49e-02 0.17100 0.015000 0.171000 8.62e-01 4.76e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 64 4.22e-04 3.84e-03 0.17100 0.168000 -0.032800 2.01e-02 6.50e-01
G ALPHA Z SIGNALLING EVENTS 44 7.86e-04 6.02e-03 0.17100 -0.105000 0.134000 2.26e-01 1.23e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 2.51e-01 4.32e-01 0.17000 -0.162000 -0.053200 1.53e-01 6.39e-01
NICOTINATE METABOLISM 25 4.71e-01 6.57e-01 0.17000 -0.141000 -0.094800 2.22e-01 4.12e-01
GLYCOSAMINOGLYCAN METABOLISM 114 5.93e-03 2.92e-02 0.17000 0.065000 0.157000 2.31e-01 3.78e-03
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 5.62e-01 7.35e-01 0.16900 -0.161000 -0.053000 3.56e-01 7.61e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 6.16e-01 7.75e-01 0.16900 -0.144000 -0.088100 3.33e-01 5.55e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 3.78e-01 5.67e-01 0.16900 -0.157000 -0.062200 2.12e-01 6.22e-01
SENSORY PERCEPTION 149 2.57e-02 9.06e-02 0.16900 0.117000 0.122000 1.38e-02 1.02e-02
PURINE SALVAGE 12 6.97e-01 8.34e-01 0.16900 -0.141000 -0.093200 3.98e-01 5.76e-01
AMINE LIGAND BINDING RECEPTORS 28 2.73e-01 4.56e-01 0.16900 0.061600 0.157000 5.72e-01 1.50e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 2.97e-04 2.91e-03 0.16800 -0.032800 0.165000 6.38e-01 1.78e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 4.41e-01 6.36e-01 0.16800 0.164000 0.036700 3.06e-01 8.19e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 2.55e-01 4.38e-01 0.16700 -0.127000 -0.109000 1.04e-01 1.63e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 5.02e-01 6.84e-01 0.16700 0.080100 0.146000 5.35e-01 2.57e-01
TRNA PROCESSING 105 6.29e-02 1.71e-01 0.16700 -0.101000 -0.133000 7.43e-02 1.87e-02
HIV TRANSCRIPTION ELONGATION 42 2.58e-01 4.42e-01 0.16700 -0.144000 -0.084400 1.08e-01 3.44e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 1.15e-01 2.50e-01 0.16600 0.162000 0.038400 9.35e-02 6.90e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 4.20e-02 1.30e-01 0.16600 -0.161000 0.042000 1.56e-01 7.11e-01
HCMV LATE EVENTS 64 5.62e-02 1.59e-01 0.16600 -0.155000 -0.059900 3.26e-02 4.07e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 9.73e-02 2.25e-01 0.16600 -0.086700 -0.141000 1.92e-01 3.35e-02
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 120 2.05e-04 2.28e-03 0.16600 0.023000 0.164000 6.64e-01 1.94e-03
METABOLISM OF NUCLEOTIDES 92 4.60e-02 1.39e-01 0.16500 -0.145000 -0.079700 1.66e-02 1.86e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 4.84e-01 6.68e-01 0.16500 -0.129000 -0.103000 2.30e-01 3.36e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 3.85e-02 1.22e-01 0.16500 0.016200 0.164000 8.54e-01 6.25e-02
RHO GTPASES ACTIVATE PKNS 46 1.79e-01 3.41e-01 0.16500 -0.148000 -0.072000 8.17e-02 3.98e-01
GAB1 SIGNALOSOME 14 5.67e-01 7.38e-01 0.16500 0.066200 0.151000 6.68e-01 3.29e-01
GLUCONEOGENESIS 27 5.24e-01 7.04e-01 0.16400 -0.108000 -0.124000 3.32e-01 2.65e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.94e-01 3.60e-01 0.16400 0.164000 0.012000 1.94e-01 9.24e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 4.36e-02 1.34e-01 0.16400 -0.164000 0.006100 9.83e-02 9.51e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.50e-01 4.31e-01 0.16400 0.163000 0.013200 2.30e-01 9.23e-01
CARGO CONCENTRATION IN THE ER 31 6.51e-02 1.74e-01 0.16400 -0.164000 0.001290 1.15e-01 9.90e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 48 2.27e-01 4.03e-01 0.16300 0.083200 0.141000 3.19e-01 9.19e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 29 4.35e-01 6.30e-01 0.16300 -0.088700 -0.137000 4.09e-01 2.01e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 3.06e-01 4.91e-01 0.16300 -0.042700 0.157000 8.15e-01 3.89e-01
INTERLEUKIN 1 FAMILY SIGNALING 122 6.28e-02 1.71e-01 0.16200 -0.118000 -0.111000 2.47e-02 3.37e-02
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.60e-01 3.13e-01 0.16200 -0.132000 -0.093600 5.56e-02 1.76e-01
AMYLOID FIBER FORMATION 55 4.97e-03 2.63e-02 0.16200 -0.161000 0.014800 3.87e-02 8.49e-01
INTERLEUKIN 10 SIGNALING 19 6.14e-02 1.69e-01 0.16100 -0.111000 0.118000 4.04e-01 3.75e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 5.61e-01 7.35e-01 0.16000 -0.116000 -0.111000 3.07e-01 3.28e-01
NETRIN 1 SIGNALING 50 3.22e-01 5.05e-01 0.16000 0.105000 0.121000 2.00e-01 1.39e-01
MITOCHONDRIAL BIOGENESIS 93 9.84e-03 4.25e-02 0.16000 -0.045300 -0.153000 4.50e-01 1.07e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 6.24e-01 7.78e-01 0.16000 -0.140000 -0.077200 3.48e-01 6.05e-01
SIGNALING BY GPCR 483 8.42e-09 3.30e-07 0.16000 0.061800 0.147000 2.04e-02 3.19e-08
G ALPHA Q SIGNALLING EVENTS 157 7.60e-05 9.61e-04 0.15900 0.028400 0.156000 5.40e-01 7.35e-04
REGULATION OF BETA CELL DEVELOPMENT 29 1.51e-01 3.03e-01 0.15900 0.021900 0.157000 8.38e-01 1.43e-01
RNA POLYMERASE I TRANSCRIPTION 66 2.59e-02 9.10e-02 0.15800 -0.154000 -0.035400 3.02e-02 6.19e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 4.43e-01 6.38e-01 0.15800 0.146000 0.061200 2.47e-01 6.27e-01
TOLL LIKE RECEPTOR CASCADES 141 3.71e-02 1.19e-01 0.15800 -0.125000 -0.096500 1.04e-02 4.82e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT 195 2.66e-03 1.63e-02 0.15800 0.076400 0.138000 6.62e-02 8.82e-04
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 5.76e-01 7.41e-01 0.15700 -0.152000 -0.041800 3.84e-01 8.10e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 6.96e-01 8.34e-01 0.15700 -0.131000 -0.086800 3.97e-01 5.74e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 8.71e-02 2.10e-01 0.15700 0.098900 0.122000 7.47e-02 2.82e-02
NEUTROPHIL DEGRANULATION 393 6.37e-08 2.20e-06 0.15600 -0.148000 -0.051800 5.40e-07 7.86e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 3.53e-01 5.40e-01 0.15600 -0.144000 -0.061600 1.88e-01 5.73e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 5.67e-01 7.38e-01 0.15600 0.050400 0.148000 7.53e-01 3.57e-01
MITOTIC PROMETAPHASE 176 8.58e-04 6.47e-03 0.15600 -0.055600 -0.146000 2.04e-01 8.58e-04
MTOR SIGNALLING 41 4.20e-01 6.13e-01 0.15600 -0.114000 -0.106000 2.06e-01 2.39e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 5.09e-01 6.91e-01 0.15600 0.145000 0.056300 3.01e-01 6.88e-01
EXTENSION OF TELOMERES 49 2.87e-01 4.71e-01 0.15500 -0.130000 -0.085600 1.16e-01 3.00e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 5.71e-01 7.39e-01 0.15400 -0.113000 -0.105000 3.09e-01 3.45e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 1.02e-01 2.33e-01 0.15400 0.098500 0.119000 7.86e-02 3.42e-02
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 6.58e-01 8.06e-01 0.15400 0.050900 0.145000 7.80e-01 4.26e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 5.69e-01 7.38e-01 0.15400 0.143000 0.057900 3.39e-01 6.98e-01
SIGNALING BY EGFR 47 3.00e-01 4.85e-01 0.15400 0.082900 0.130000 3.26e-01 1.25e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 95 1.16e-03 8.29e-03 0.15300 0.006940 0.153000 9.07e-01 9.88e-03
TRANSCRIPTIONAL REGULATION BY E2F6 34 7.05e-02 1.83e-01 0.15300 0.002450 -0.153000 9.80e-01 1.22e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 6.69e-01 8.15e-01 0.15300 0.107000 0.109000 4.07e-01 4.00e-01
GPCR LIGAND BINDING 268 2.66e-07 7.98e-06 0.15300 0.025700 0.150000 4.69e-01 2.31e-05
PLATELET AGGREGATION PLUG FORMATION 32 5.27e-01 7.05e-01 0.15200 0.107000 0.108000 2.95e-01 2.88e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 3.66e-02 1.18e-01 0.15200 -0.057500 0.141000 5.92e-01 1.89e-01
PLATELET SENSITIZATION BY LDL 15 4.55e-01 6.46e-01 0.15200 -0.149000 -0.031900 3.19e-01 8.31e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 62 1.11e-01 2.45e-01 0.15200 -0.140000 -0.059100 5.68e-02 4.21e-01
STIMULI SENSING CHANNELS 76 1.10e-01 2.44e-01 0.15100 0.134000 0.071100 4.40e-02 2.84e-01
BASE EXCISION REPAIR AP SITE FORMATION 28 1.02e-01 2.33e-01 0.15100 -0.151000 0.010000 1.67e-01 9.27e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 3.00e-01 4.85e-01 0.15100 -0.145000 -0.042600 1.93e-01 7.01e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 245 3.64e-03 2.08e-02 0.15100 0.085200 0.124000 2.19e-02 8.30e-04
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 7.31e-01 8.55e-01 0.15000 -0.126000 -0.081100 4.32e-01 6.13e-01
GPVI MEDIATED ACTIVATION CASCADE 31 2.20e-01 3.94e-01 0.15000 -0.146000 -0.034500 1.60e-01 7.40e-01
ADHERENS JUNCTIONS INTERACTIONS 30 2.87e-01 4.71e-01 0.14900 0.045500 0.142000 6.66e-01 1.77e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 7.30e-01 8.55e-01 0.14900 0.118000 0.090900 4.28e-01 5.42e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 7.39e-01 8.60e-01 0.14900 -0.095000 -0.115000 5.24e-01 4.41e-01
PLATELET CALCIUM HOMEOSTASIS 25 5.33e-01 7.11e-01 0.14900 0.127000 0.077200 2.70e-01 5.04e-01
MHC CLASS II ANTIGEN PRESENTATION 101 6.43e-02 1.73e-01 0.14900 -0.071500 -0.130000 2.15e-01 2.38e-02
DEATH RECEPTOR SIGNALLING 133 5.58e-02 1.59e-01 0.14800 0.086400 0.121000 8.57e-02 1.63e-02
INTERLEUKIN 17 SIGNALING 68 2.66e-01 4.50e-01 0.14800 -0.112000 -0.096600 1.09e-01 1.69e-01
COLLAGEN FORMATION 81 1.31e-03 9.15e-03 0.14800 0.147000 -0.016000 2.24e-02 8.04e-01
ONCOGENIC MAPK SIGNALING 76 1.04e-01 2.36e-01 0.14700 0.064500 0.133000 3.31e-01 4.58e-02
LONG TERM POTENTIATION 23 3.69e-01 5.58e-01 0.14700 0.141000 0.039800 2.41e-01 7.41e-01
CA DEPENDENT EVENTS 36 5.11e-01 6.92e-01 0.14700 0.105000 0.103000 2.75e-01 2.87e-01
RESOLUTION OF ABASIC SITES AP SITES 37 3.13e-01 4.97e-01 0.14700 -0.134000 -0.060600 1.59e-01 5.24e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 187 2.63e-04 2.74e-03 0.14700 0.037600 0.142000 3.75e-01 8.38e-04
AQUAPORIN MEDIATED TRANSPORT 42 6.56e-03 3.18e-02 0.14600 -0.096100 0.110000 2.81e-01 2.18e-01
ATTENUATION PHASE 24 7.45e-02 1.90e-01 0.14500 0.063600 -0.131000 5.90e-01 2.68e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 3.15e-01 4.99e-01 0.14500 -0.114000 -0.088500 1.29e-01 2.40e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 31 3.08e-02 1.03e-01 0.14400 -0.075500 0.123000 4.67e-01 2.35e-01
OTHER INTERLEUKIN SIGNALING 20 6.31e-01 7.81e-01 0.14400 0.076000 0.122000 5.56e-01 3.44e-01
IRS MEDIATED SIGNALLING 40 4.09e-01 6.03e-01 0.14400 -0.077900 -0.121000 3.94e-01 1.85e-01
PROTEIN FOLDING 89 9.09e-02 2.16e-01 0.14400 -0.128000 -0.065700 3.72e-02 2.84e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 90 7.23e-04 5.74e-03 0.14400 -0.019800 0.142000 7.46e-01 1.96e-02
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 79 3.99e-04 3.70e-03 0.14400 0.050100 -0.135000 4.42e-01 3.86e-02
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 6.99e-01 8.35e-01 0.14300 0.118000 0.080000 3.99e-01 5.68e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 1.86e-05 3.43e-04 0.14300 -0.136000 -0.042200 7.68e-05 2.22e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 61 3.21e-01 5.04e-01 0.14300 -0.111000 -0.089500 1.34e-01 2.27e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 5.60e-01 7.35e-01 0.14200 -0.070900 -0.124000 5.48e-01 2.95e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 4.43e-01 6.38e-01 0.14200 -0.140000 -0.022300 3.31e-01 8.77e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.58e-02 6.17e-02 0.14200 -0.135000 0.044700 1.22e-01 6.08e-01
PEPTIDE LIGAND BINDING RECEPTORS 111 3.88e-03 2.18e-02 0.14200 0.022700 0.140000 6.79e-01 1.08e-02
RHO GTPASE CYCLE 426 7.14e-04 5.71e-03 0.14200 0.102000 0.098300 3.06e-04 5.20e-04
FOXO MEDIATED TRANSCRIPTION 59 1.73e-03 1.12e-02 0.14200 -0.121000 0.073400 1.07e-01 3.29e-01
EPHB MEDIATED FORWARD SIGNALING 42 3.23e-01 5.06e-01 0.14100 -0.127000 -0.063000 1.56e-01 4.80e-01
REGULATION OF IFNG SIGNALING 13 5.92e-01 7.52e-01 0.14100 -0.136000 -0.038000 3.95e-01 8.13e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 18 6.27e-01 7.79e-01 0.14100 -0.125000 -0.065100 3.57e-01 6.33e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 53 5.67e-03 2.83e-02 0.14100 0.052600 -0.131000 5.08e-01 9.91e-02
O LINKED GLYCOSYLATION 86 2.04e-01 3.73e-01 0.14100 0.111000 0.086700 7.51e-02 1.65e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 1.16e-01 2.51e-01 0.14100 -0.129000 -0.057300 5.61e-02 3.94e-01
INNATE IMMUNE SYSTEM 790 1.07e-10 8.96e-09 0.14100 -0.129000 -0.054800 7.34e-10 9.18e-03
PYRIMIDINE SALVAGE 10 8.14e-01 9.09e-01 0.14000 0.077000 0.116000 6.73e-01 5.24e-01
NEGATIVE REGULATION OF FLT3 14 7.29e-01 8.55e-01 0.13900 0.120000 0.070400 4.37e-01 6.48e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 2.07e-01 3.79e-01 0.13900 0.102000 0.094400 8.78e-02 1.14e-01
SNRNP ASSEMBLY 51 3.11e-01 4.96e-01 0.13800 -0.120000 -0.068600 1.38e-01 3.97e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 7.30e-01 8.55e-01 0.13800 -0.065100 -0.122000 6.84e-01 4.47e-01
AUTOPHAGY 140 4.96e-02 1.46e-01 0.13800 -0.118000 -0.071200 1.61e-02 1.46e-01
DNA REPAIR 288 6.60e-03 3.18e-02 0.13700 -0.109000 -0.083700 1.55e-03 1.47e-02
VISUAL PHOTOTRANSDUCTION 59 6.81e-02 1.79e-01 0.13700 0.024000 0.135000 7.50e-01 7.31e-02
P75NTR SIGNALS VIA NF KB 16 6.38e-01 7.86e-01 0.13700 0.125000 0.054800 3.85e-01 7.04e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.67e-01 8.80e-01 0.13700 0.063500 0.121000 7.15e-01 4.87e-01
SIGNALING BY FGFR4 IN DISEASE 11 5.11e-01 6.92e-01 0.13600 -0.136000 0.001130 4.35e-01 9.95e-01
SYNDECAN INTERACTIONS 26 5.31e-01 7.09e-01 0.13600 0.061900 0.121000 5.85e-01 2.85e-01
KERATAN SULFATE BIOSYNTHESIS 24 8.55e-02 2.07e-01 0.13600 -0.081800 0.108000 4.88e-01 3.58e-01
DISEASES OF METABOLISM 198 3.38e-02 1.11e-01 0.13600 0.107000 0.082900 9.35e-03 4.46e-02
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 6.85e-01 8.26e-01 0.13600 0.041200 0.129000 8.13e-01 4.58e-01
SIGNALING BY BMP 25 1.01e-01 2.33e-01 0.13500 -0.054500 0.124000 6.37e-01 2.85e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 108 5.56e-04 4.74e-03 0.13500 0.134000 -0.016200 1.61e-02 7.71e-01
SIGNALING BY NODAL 15 2.31e-01 4.08e-01 0.13500 -0.069300 0.116000 6.42e-01 4.37e-01
ADAPTIVE IMMUNE SYSTEM 613 5.04e-05 7.22e-04 0.13500 -0.105000 -0.084700 9.67e-06 3.63e-04
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 86 6.82e-04 5.57e-03 0.13500 0.042400 -0.128000 4.97e-01 4.03e-02
INFECTIOUS DISEASE 734 7.94e-13 2.19e-10 0.13500 -0.131000 -0.031200 1.73e-09 1.52e-01
DAP12 SIGNALING 24 9.07e-02 2.16e-01 0.13500 -0.079200 0.109000 5.02e-01 3.57e-01
SIGNALING BY RETINOIC ACID 34 5.08e-01 6.90e-01 0.13400 -0.114000 -0.071300 2.50e-01 4.72e-01
DNA DOUBLE STRAND BREAK REPAIR 134 4.48e-02 1.37e-01 0.13400 -0.062100 -0.119000 2.15e-01 1.74e-02
INTRINSIC PATHWAY FOR APOPTOSIS 52 3.70e-01 5.58e-01 0.13400 -0.112000 -0.073000 1.62e-01 3.63e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 3.12e-01 4.96e-01 0.13400 -0.113000 0.072100 4.99e-01 6.66e-01
LYSINE CATABOLISM 11 3.46e-01 5.33e-01 0.13300 0.112000 -0.072300 5.20e-01 6.78e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 6.92e-01 8.31e-01 0.13300 -0.092500 -0.095900 4.33e-01 4.16e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 2.21e-01 3.96e-01 0.13200 -0.115000 -0.066000 9.07e-02 3.30e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 1.51e-01 3.04e-01 0.13200 -0.132000 0.003630 1.96e-01 9.72e-01
KILLING MECHANISMS 11 8.33e-01 9.21e-01 0.13200 0.079700 0.105000 6.47e-01 5.46e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 7.03e-01 8.37e-01 0.13200 -0.110000 -0.071900 4.05e-01 5.88e-01
MYD88 INDEPENDENT TLR4 CASCADE 94 1.99e-01 3.67e-01 0.13200 -0.107000 -0.076300 7.25e-02 2.01e-01
ION CHANNEL TRANSPORT 142 8.78e-02 2.11e-01 0.13200 0.107000 0.076300 2.75e-02 1.17e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 6.63e-01 8.10e-01 0.13100 -0.030800 -0.128000 8.60e-01 4.63e-01
LYSOSOME VESICLE BIOGENESIS 33 6.08e-01 7.68e-01 0.13100 -0.097700 -0.087300 3.32e-01 3.86e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 176 5.84e-04 4.95e-03 0.13100 -0.129000 -0.021200 3.13e-03 6.27e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 6.21e-01 7.78e-01 0.13100 0.114000 0.064300 3.44e-01 5.94e-01
PLASMA LIPOPROTEIN CLEARANCE 27 6.73e-01 8.16e-01 0.13000 0.093300 0.090700 4.01e-01 4.15e-01
CD209 DC SIGN SIGNALING 18 3.62e-01 5.51e-01 0.13000 -0.130000 0.002150 3.39e-01 9.87e-01
POLO LIKE KINASE MEDIATED EVENTS 13 7.52e-01 8.68e-01 0.13000 -0.115000 -0.060000 4.72e-01 7.08e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 53 7.28e-03 3.43e-02 0.12900 -0.103000 0.077900 1.93e-01 3.27e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 1.61e-01 3.14e-01 0.12900 0.040300 0.123000 5.90e-01 1.01e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 3.21e-01 5.04e-01 0.12900 0.113000 -0.061500 4.80e-01 7.01e-01
RAP1 SIGNALLING 15 7.47e-01 8.65e-01 0.12900 -0.064900 -0.111000 6.64e-01 4.56e-01
SIGNALING BY NTRK2 TRKB 24 6.21e-01 7.78e-01 0.12800 0.062800 0.112000 5.95e-01 3.44e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 4.96e-03 2.63e-02 0.12800 0.015800 -0.127000 8.01e-01 4.35e-02
AURKA ACTIVATION BY TPX2 72 3.86e-03 2.18e-02 0.12800 0.042300 -0.121000 5.36e-01 7.72e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 7.02e-01 8.37e-01 0.12800 0.106000 0.071400 4.02e-01 5.71e-01
ACYL CHAIN REMODELLING OF PG 10 6.34e-01 7.84e-01 0.12700 -0.011700 -0.127000 9.49e-01 4.88e-01
ACYL CHAIN REMODELLING OF PS 14 7.97e-01 8.99e-01 0.12700 -0.104000 -0.073100 5.01e-01 6.36e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 4.96e-01 6.79e-01 0.12700 -0.096100 -0.083100 2.45e-01 3.14e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 3.53e-01 5.40e-01 0.12600 -0.116000 -0.047900 1.92e-01 5.91e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 9.23e-02 2.19e-01 0.12600 0.117000 -0.045600 2.59e-01 6.60e-01
SIGNALING BY ERYTHROPOIETIN 24 4.64e-01 6.51e-01 0.12600 0.033500 0.121000 7.77e-01 3.05e-01
INWARDLY RECTIFYING K CHANNELS 32 8.50e-02 2.07e-01 0.12500 -0.117000 0.046500 2.54e-01 6.49e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 550 2.41e-11 2.36e-09 0.12500 -0.125000 -0.008640 5.98e-07 7.30e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 92 2.86e-01 4.71e-01 0.12500 -0.083500 -0.092800 1.67e-01 1.24e-01
RHO GTPASES ACTIVATE PAKS 21 5.19e-01 6.99e-01 0.12500 0.120000 0.033700 3.41e-01 7.90e-01
RHO GTPASES ACTIVATE CIT 18 7.73e-01 8.84e-01 0.12400 0.097200 0.077800 4.76e-01 5.68e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 7.08e-02 1.83e-01 0.12400 0.124000 0.002150 1.14e-01 9.78e-01
ASSEMBLY OF THE HIV VIRION 16 7.80e-01 8.88e-01 0.12400 -0.102000 -0.071600 4.81e-01 6.20e-01
METABOLISM OF FOLATE AND PTERINES 15 2.71e-01 4.54e-01 0.12400 0.089100 -0.086600 5.50e-01 5.62e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 3.77e-01 5.66e-01 0.12400 -0.108000 0.060500 5.16e-01 7.16e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 6.76e-01 8.19e-01 0.12400 -0.108000 -0.060500 3.92e-01 6.31e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 3.17e-01 5.01e-01 0.12300 -0.083000 -0.091000 1.81e-01 1.43e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 2.73e-01 4.56e-01 0.12200 -0.028900 0.119000 8.23e-01 3.58e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 7.13e-02 1.84e-01 0.12200 -0.107000 -0.057900 2.72e-02 2.34e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.70e-01 3.28e-01 0.12100 -0.037300 -0.116000 6.03e-01 1.07e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 97 1.98e-03 1.27e-02 0.12100 0.118000 -0.029200 4.50e-02 6.19e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 7.47e-01 8.65e-01 0.12100 0.087800 0.083200 4.66e-01 4.90e-01
MYOGENESIS 25 7.30e-01 8.55e-01 0.12100 0.082800 0.087500 4.74e-01 4.49e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 6.50e-01 7.99e-01 0.12000 0.117000 0.029200 4.50e-01 8.50e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 6.15e-01 7.75e-01 0.12000 -0.078700 -0.090800 4.01e-01 3.33e-01
G ALPHA I SIGNALLING EVENTS 204 1.18e-03 8.29e-03 0.12000 0.024000 0.118000 5.55e-01 3.81e-03
KERATAN SULFATE KERATIN METABOLISM 30 1.09e-01 2.43e-01 0.12000 -0.052600 0.108000 6.18e-01 3.07e-01
MRNA SPLICING 188 9.66e-02 2.24e-01 0.12000 -0.088600 -0.080600 3.63e-02 5.69e-02
ACYL CHAIN REMODELLING OF PC 17 7.62e-01 8.77e-01 0.11900 0.102000 0.062500 4.67e-01 6.56e-01
MEIOSIS 63 1.65e-01 3.22e-01 0.11900 -0.115000 -0.032400 1.15e-01 6.57e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 2.41e-03 1.52e-02 0.11900 -0.118000 -0.019300 7.89e-03 6.64e-01
KERATAN SULFATE DEGRADATION 11 8.73e-01 9.46e-01 0.11900 0.083300 0.085400 6.32e-01 6.24e-01
MAP2K AND MAPK ACTIVATION 36 4.51e-01 6.42e-01 0.11900 0.045900 0.110000 6.34e-01 2.53e-01
UB SPECIFIC PROCESSING PROTEASES 169 1.06e-01 2.39e-01 0.11900 -0.094400 -0.072200 3.44e-02 1.06e-01
TIE2 SIGNALING 17 7.26e-01 8.55e-01 0.11900 -0.106000 -0.053000 4.49e-01 7.05e-01
HEME SIGNALING 45 1.45e-01 2.97e-01 0.11800 0.118000 0.004610 1.70e-01 9.57e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 4.97e-01 6.80e-01 0.11800 -0.116000 -0.022000 3.57e-01 8.61e-01
MEIOTIC SYNAPSIS 40 1.29e-01 2.72e-01 0.11800 -0.118000 0.010100 1.97e-01 9.12e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1223 6.34e-10 4.97e-08 0.11800 -0.105000 -0.052900 7.47e-10 2.02e-03
PREGNENOLONE BIOSYNTHESIS 12 7.31e-01 8.55e-01 0.11800 -0.035600 -0.112000 8.31e-01 5.01e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 7.96e-01 8.98e-01 0.11700 -0.086300 -0.079600 5.15e-01 5.48e-01
CELLULAR RESPONSE TO HEAT STRESS 95 2.62e-01 4.45e-01 0.11700 -0.065500 -0.096900 2.70e-01 1.03e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 7.71e-01 8.83e-01 0.11700 -0.101000 -0.058100 4.83e-01 6.87e-01
COLLAGEN DEGRADATION 51 2.05e-02 7.51e-02 0.11700 0.074200 -0.090200 3.60e-01 2.65e-01
RHOBTB GTPASE CYCLE 35 6.26e-01 7.79e-01 0.11700 -0.068100 -0.094600 4.86e-01 3.33e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 7.34e-01 8.56e-01 0.11600 0.077800 0.086600 4.93e-01 4.45e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 7.68e-01 8.80e-01 0.11600 -0.074800 -0.088400 5.43e-01 4.73e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.87e-01 8.27e-01 0.11600 -0.115000 -0.010800 5.28e-01 9.53e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 6.61e-01 8.08e-01 0.11500 0.113000 0.021000 4.79e-01 8.96e-01
TRANSCRIPTIONAL REGULATION BY TP53 346 2.07e-02 7.56e-02 0.11500 -0.079400 -0.083000 1.14e-02 8.12e-03
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 8.52e-01 9.33e-01 0.11400 -0.090400 -0.070000 5.73e-01 6.62e-01
ION HOMEOSTASIS 49 4.17e-01 6.11e-01 0.11400 0.103000 0.050000 2.14e-01 5.45e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 1.31e-02 5.30e-02 0.11400 -0.114000 0.007210 5.65e-02 9.04e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 3.61e-01 5.51e-01 0.11400 -0.114000 -0.011000 2.99e-01 9.20e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 95 3.41e-01 5.29e-01 0.11400 -0.084700 -0.076000 1.54e-01 2.00e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 5.62e-01 7.35e-01 0.11400 0.042700 0.105000 6.96e-01 3.34e-01
GABA RECEPTOR ACTIVATION 55 4.59e-02 1.39e-01 0.11300 -0.027400 0.110000 7.25e-01 1.59e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 3.77e-01 5.66e-01 0.11300 0.024600 0.110000 8.04e-01 2.65e-01
SMOOTH MUSCLE CONTRACTION 33 1.53e-01 3.05e-01 0.11200 0.108000 -0.030900 2.83e-01 7.59e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 7.32e-01 8.55e-01 0.11200 -0.048900 -0.101000 7.20e-01 4.58e-01
FGFR2 ALTERNATIVE SPLICING 25 7.62e-01 8.77e-01 0.11200 -0.079100 -0.079500 4.94e-01 4.92e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 7.80e-02 1.95e-01 0.11200 -0.082100 -0.076100 2.98e-02 4.39e-02
SELECTIVE AUTOPHAGY 73 4.58e-01 6.48e-01 0.11100 -0.080300 -0.077100 2.36e-01 2.55e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 2.20e-01 3.94e-01 0.11100 -0.039500 -0.104000 5.57e-01 1.23e-01
HEDGEHOG ON STATE 83 3.30e-01 5.15e-01 0.11100 -0.093500 -0.059300 1.41e-01 3.50e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 5.99e-01 7.59e-01 0.11100 0.054700 0.096100 5.76e-01 3.25e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 2.80e-01 4.63e-01 0.11000 -0.110000 0.000243 2.79e-01 9.98e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 8.07e-01 9.04e-01 0.11000 0.071500 0.083300 5.80e-01 5.19e-01
PHOSPHOLIPID METABOLISM 187 1.18e-01 2.54e-01 0.11000 0.065900 0.087700 1.20e-01 3.87e-02
TBC RABGAPS 43 3.00e-01 4.85e-01 0.11000 -0.108000 -0.021500 2.23e-01 8.07e-01
DEUBIQUITINATION 243 6.50e-02 1.74e-01 0.11000 -0.087200 -0.066300 1.95e-02 7.55e-02
RHO GTPASES ACTIVATE ROCKS 19 2.86e-01 4.71e-01 0.10900 0.088900 -0.063700 5.02e-01 6.31e-01
DISEASES OF DNA REPAIR 11 5.96e-01 7.55e-01 0.10900 0.108000 -0.016100 5.35e-01 9.26e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 7.08e-01 8.40e-01 0.10900 -0.082000 -0.071300 4.15e-01 4.78e-01
FORMATION OF THE CORNIFIED ENVELOPE 26 4.48e-01 6.41e-01 0.10900 0.014600 0.108000 8.98e-01 3.42e-01
KERATINIZATION 26 4.48e-01 6.41e-01 0.10900 0.014600 0.108000 8.98e-01 3.42e-01
TRP CHANNELS 20 8.11e-01 9.07e-01 0.10800 0.070500 0.082400 5.85e-01 5.24e-01
PTEN REGULATION 136 1.51e-01 3.03e-01 0.10800 -0.094000 -0.053600 5.86e-02 2.81e-01
COMPLEMENT CASCADE 27 7.61e-01 8.77e-01 0.10700 0.080800 0.069500 4.68e-01 5.32e-01
SIGNALING BY MET 74 3.90e-01 5.80e-01 0.10600 0.090600 0.054500 1.78e-01 4.18e-01
PEPTIDE HORMONE METABOLISM 59 7.35e-02 1.88e-01 0.10600 -0.104000 0.016200 1.66e-01 8.30e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 2.56e-02 9.04e-02 0.10500 -0.093500 0.048000 1.96e-01 5.07e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 5.84e-01 7.45e-01 0.10500 -0.010900 0.105000 9.46e-01 5.14e-01
POTASSIUM CHANNELS 91 4.15e-01 6.09e-01 0.10500 0.069000 0.078700 2.56e-01 1.94e-01
RHO GTPASE EFFECTORS 250 9.05e-02 2.16e-01 0.10400 -0.067200 -0.079600 6.76e-02 3.05e-02
SIGNALING BY FGFR IN DISEASE 57 5.82e-01 7.43e-01 0.10400 -0.077600 -0.069300 3.11e-01 3.66e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 7.76e-01 8.86e-01 0.10300 0.048500 0.090600 7.15e-01 4.94e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 3.01e-03 1.78e-02 0.10300 -0.102000 0.015200 3.80e-02 7.56e-01
IRAK1 RECRUITS IKK COMPLEX 14 8.57e-01 9.35e-01 0.10300 0.085300 0.057000 5.81e-01 7.12e-01
INTERLEUKIN 27 SIGNALING 10 8.57e-01 9.35e-01 0.10200 0.041800 0.093300 8.19e-01 6.09e-01
SIGNALLING TO RAS 20 7.48e-01 8.65e-01 0.10200 0.044100 0.092200 7.33e-01 4.76e-01
HSF1 DEPENDENT TRANSACTIVATION 34 1.36e-01 2.83e-01 0.10200 0.076000 -0.068200 4.43e-01 4.91e-01
ESR MEDIATED SIGNALING 166 6.40e-04 5.30e-03 0.10200 -0.099500 0.022600 2.71e-02 6.15e-01
INSULIN RECEPTOR SIGNALLING CASCADE 45 6.35e-01 7.84e-01 0.10200 -0.060500 -0.082100 4.83e-01 3.41e-01
RHOH GTPASE CYCLE 37 2.72e-01 4.55e-01 0.10100 -0.101000 0.004260 2.88e-01 9.64e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 2.59e-01 4.43e-01 0.10100 -0.043400 0.091000 7.02e-01 4.22e-01
JOSEPHIN DOMAIN DUBS 11 8.17e-01 9.11e-01 0.10000 -0.031900 -0.095300 8.55e-01 5.84e-01
SIGNALING BY INTERLEUKINS 351 1.87e-03 1.21e-02 0.10000 -0.095000 -0.031700 2.28e-03 3.09e-01
SIGNALING BY WNT 266 4.80e-05 7.06e-04 0.10000 -0.099500 0.011100 5.26e-03 7.56e-01
RNA POLYMERASE II TRANSCRIPTION 1097 7.07e-05 9.14e-04 0.10000 -0.078500 -0.062000 1.32e-05 5.75e-04
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 8.00e-01 9.00e-01 0.09960 0.068600 0.072100 5.45e-01 5.24e-01
SIGNALING BY FGFR1 44 6.37e-01 7.85e-01 0.09930 -0.082400 -0.055400 3.44e-01 5.25e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 183 1.31e-01 2.74e-01 0.09920 0.051200 0.085000 2.33e-01 4.77e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 6.78e-01 8.20e-01 0.09910 -0.008990 -0.098700 9.54e-01 5.22e-01
THE PHOTOTRANSDUCTION CASCADE 21 7.23e-01 8.52e-01 0.09780 0.036000 0.090900 7.75e-01 4.71e-01
RHOJ GTPASE CYCLE 55 6.16e-01 7.75e-01 0.09740 0.076600 0.060200 3.26e-01 4.40e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 7.22e-01 8.52e-01 0.09720 -0.083500 -0.049800 4.29e-01 6.37e-01
SIGNALING BY ERBB2 48 6.68e-01 8.15e-01 0.09700 -0.073900 -0.062700 3.76e-01 4.52e-01
P38MAPK EVENTS 13 7.89e-01 8.93e-01 0.09650 -0.092600 -0.027400 5.63e-01 8.64e-01
CELL CELL COMMUNICATION 107 1.20e-01 2.57e-01 0.09630 0.022900 0.093500 6.82e-01 9.48e-02
SIGNALING BY FGFR2 64 5.76e-01 7.41e-01 0.09600 -0.058900 -0.075800 4.16e-01 2.94e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 5.12e-01 6.92e-01 0.09580 0.018400 0.094100 8.59e-01 3.65e-01
PARASITE INFECTION 54 2.97e-01 4.83e-01 0.09530 -0.094000 -0.015600 2.32e-01 8.43e-01
OPIOID SIGNALLING 86 1.07e-01 2.42e-01 0.09490 0.007160 0.094600 9.09e-01 1.30e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 6.85e-01 8.26e-01 0.09460 -0.086800 -0.037600 4.27e-01 7.31e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 96 4.65e-01 6.51e-01 0.09460 -0.072100 -0.061200 2.22e-01 3.01e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 8.96e-01 9.59e-01 0.09440 -0.078000 -0.053200 6.40e-01 7.50e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 6.73e-01 8.16e-01 0.09420 -0.009070 -0.093700 9.50e-01 5.16e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 78 2.17e-02 7.86e-02 0.09350 -0.062900 0.069200 3.37e-01 2.91e-01
HCMV INFECTION 102 2.42e-01 4.22e-01 0.09300 -0.086400 -0.034300 1.32e-01 5.50e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 105 7.71e-03 3.56e-02 0.09230 -0.076700 0.051300 1.74e-01 3.64e-01
HS GAG BIOSYNTHESIS 30 5.55e-01 7.31e-01 0.09210 0.018500 0.090300 8.61e-01 3.92e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 5.56e-01 7.31e-01 0.09200 -0.034000 -0.085500 7.00e-01 3.32e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 7.80e-01 8.88e-01 0.09170 -0.011000 -0.091100 9.50e-01 6.01e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 4.51e-01 6.42e-01 0.09160 -0.076200 -0.050800 2.09e-01 4.03e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.98e-01 3.65e-01 0.09100 -0.070500 0.057600 4.71e-01 5.55e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 16 8.69e-01 9.44e-01 0.09090 0.049800 0.076000 7.30e-01 5.98e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.03e-01 2.35e-01 0.09070 -0.000218 0.090700 9.97e-01 1.49e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 16 4.83e-01 6.67e-01 0.09000 0.059200 -0.067700 6.82e-01 6.39e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 74 5.91e-01 7.52e-01 0.08980 -0.059400 -0.067400 3.77e-01 3.17e-01
ZINC TRANSPORTERS 16 8.04e-01 9.02e-01 0.08960 0.031000 0.084100 8.30e-01 5.60e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 6.96e-01 8.34e-01 0.08910 -0.053900 -0.071000 5.18e-01 3.95e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 6.82e-01 8.24e-01 0.08910 0.086500 -0.021500 6.19e-01 9.02e-01
SIGNALING BY NTRKS 130 4.75e-03 2.55e-02 0.08840 -0.076900 0.043500 1.30e-01 3.92e-01
PROLACTIN RECEPTOR SIGNALING 11 6.18e-01 7.76e-01 0.08830 -0.066700 0.057800 7.02e-01 7.40e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 9.03e-01 9.62e-01 0.08820 0.069800 0.053900 6.51e-01 7.27e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 8.37e-01 9.25e-01 0.08820 -0.018400 -0.086200 9.20e-01 6.37e-01
PLATELET HOMEOSTASIS 77 8.02e-02 2.00e-01 0.08790 -0.018800 0.085900 7.75e-01 1.93e-01
CIRCADIAN CLOCK 68 4.12e-01 6.06e-01 0.08750 0.030200 0.082200 6.67e-01 2.42e-01
SARS COV INFECTIONS 140 1.14e-02 4.78e-02 0.08750 -0.085700 0.017800 8.03e-02 7.17e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 5.16e-01 6.96e-01 0.08710 0.021100 0.084500 8.15e-01 3.50e-01
APOPTOTIC EXECUTION PHASE 45 4.78e-01 6.64e-01 0.08680 -0.084500 -0.020100 3.27e-01 8.16e-01
MUSCLE CONTRACTION 162 2.71e-01 4.54e-01 0.08640 0.072900 0.046300 1.10e-01 3.10e-01
HATS ACETYLATE HISTONES 92 4.58e-01 6.47e-01 0.08610 0.044000 0.073900 4.66e-01 2.21e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 7.43e-01 8.63e-01 0.08600 -0.007230 0.085700 9.67e-01 6.23e-01
SIGNAL TRANSDUCTION BY L1 21 5.64e-01 7.36e-01 0.08580 -0.085400 0.008130 4.98e-01 9.49e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 4.45e-01 6.40e-01 0.08480 -0.062700 0.057000 6.27e-01 6.59e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 147 1.24e-01 2.62e-01 0.08390 -0.080900 -0.022300 9.06e-02 6.42e-01
SIGNALING BY SCF KIT 41 6.81e-01 8.23e-01 0.08390 0.037700 0.075000 6.76e-01 4.06e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 8.47e-01 9.32e-01 0.08360 0.029000 0.078400 8.51e-01 6.12e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.33e-01 9.73e-01 0.08330 -0.052700 -0.064600 7.62e-01 7.11e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 1.89e-02 7.18e-02 0.08330 -0.061200 0.056500 2.86e-01 3.25e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 7.19e-01 8.51e-01 0.08310 0.071100 0.043000 4.25e-01 6.30e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.12e-01 4.96e-01 0.08290 -0.001380 0.082900 9.86e-01 3.06e-01
SODIUM CALCIUM EXCHANGERS 10 7.12e-01 8.44e-01 0.08260 -0.032200 0.076100 8.60e-01 6.77e-01
SIGNALING BY NUCLEAR RECEPTORS 224 2.90e-04 2.89e-03 0.08250 -0.069800 0.043900 7.21e-02 2.58e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 6.30e-01 7.81e-01 0.08240 -0.080600 0.017500 5.77e-01 9.04e-01
SIGNALING BY NOTCH 187 3.23e-03 1.87e-02 0.08240 -0.023500 0.079000 5.81e-01 6.27e-02
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 46 5.49e-01 7.27e-01 0.08230 -0.023900 -0.078700 7.79e-01 3.56e-01
TRNA AMINOACYLATION 42 4.72e-01 6.57e-01 0.08230 -0.010500 -0.081600 9.06e-01 3.60e-01
SLC TRANSPORTER DISORDERS 77 3.72e-01 5.60e-01 0.08210 0.024100 0.078500 7.14e-01 2.34e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 7.23e-01 8.52e-01 0.08200 -0.080900 0.013400 6.28e-01 9.36e-01
CARDIAC CONDUCTION 107 5.42e-01 7.19e-01 0.08160 0.057300 0.058200 3.07e-01 2.99e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 7.82e-01 8.89e-01 0.08140 0.037900 0.072000 7.24e-01 5.02e-01
MICRORNA MIRNA BIOGENESIS 24 8.70e-01 9.44e-01 0.08130 0.060900 0.053800 6.06e-01 6.48e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 93 8.14e-02 2.01e-01 0.08110 -0.014900 0.079800 8.04e-01 1.84e-01
NUCLEAR SIGNALING BY ERBB4 31 5.92e-01 7.52e-01 0.08110 0.011700 0.080200 9.10e-01 4.40e-01
LEISHMANIA INFECTION 199 3.71e-03 2.11e-02 0.08090 -0.018900 0.078700 6.46e-01 5.60e-02
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 9.14e-01 9.67e-01 0.08000 0.059700 0.053200 6.79e-01 7.13e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 5.12e-01 6.92e-01 0.07970 -0.075800 -0.024500 3.22e-01 7.49e-01
DSCAM INTERACTIONS 11 7.32e-01 8.55e-01 0.07960 0.021000 -0.076800 9.04e-01 6.59e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.02e-01 8.37e-01 0.07960 0.075600 -0.024700 6.50e-01 8.82e-01
SIGNALING BY FGFR 75 6.53e-01 8.01e-01 0.07930 -0.061100 -0.050600 3.60e-01 4.49e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 9.29e-01 9.72e-01 0.07890 -0.064000 -0.046100 7.01e-01 7.82e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.21e-01 9.14e-01 0.07880 -0.077600 -0.013600 6.28e-01 9.32e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 4.89e-01 6.72e-01 0.07830 -0.077300 -0.012800 3.59e-01 8.80e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 8.66e-01 9.43e-01 0.07830 -0.050500 -0.059900 6.56e-01 5.97e-01
RAB REGULATION OF TRAFFICKING 118 4.56e-01 6.46e-01 0.07820 -0.066100 -0.041800 2.15e-01 4.33e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.78e-01 7.42e-01 0.07810 -0.025600 0.073800 8.47e-01 5.78e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 24 5.35e-01 7.13e-01 0.07800 -0.076100 0.017200 5.19e-01 8.84e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 60 3.05e-01 4.90e-01 0.07800 -0.078000 0.000188 2.96e-01 9.98e-01
SIGNALING BY FGFR1 IN DISEASE 33 8.12e-01 9.08e-01 0.07780 0.043300 0.064600 6.67e-01 5.21e-01
REGULATED PROTEOLYSIS OF P75NTR 12 9.23e-01 9.69e-01 0.07780 0.065900 0.041400 6.93e-01 8.04e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 61 2.27e-01 4.03e-01 0.07770 -0.076700 0.012800 3.01e-01 8.63e-01
BASIGIN INTERACTIONS 22 4.80e-01 6.65e-01 0.07710 -0.049800 0.058800 6.86e-01 6.33e-01
SIGNALING BY PDGF 57 6.69e-01 8.15e-01 0.07700 0.066800 0.038300 3.83e-01 6.17e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 4.21e-01 6.13e-01 0.07660 -0.063800 0.042400 5.66e-01 7.03e-01
O LINKED GLYCOSYLATION OF MUCINS 40 2.69e-01 4.53e-01 0.07640 -0.056800 0.051100 5.34e-01 5.76e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.63e-01 8.77e-01 0.07640 -0.072700 0.023300 6.91e-01 8.99e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 9.28e-01 9.72e-01 0.07580 -0.055000 -0.052200 7.12e-01 7.27e-01
CELL CELL JUNCTION ORGANIZATION 49 2.69e-01 4.53e-01 0.07520 -0.070900 0.025000 3.91e-01 7.62e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 8.43e-01 9.29e-01 0.07510 -0.053100 -0.053200 5.87e-01 5.86e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 36 6.22e-01 7.78e-01 0.07510 -0.014700 -0.073700 8.79e-01 4.44e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 4.28e-01 6.21e-01 0.07490 0.073300 -0.015300 4.47e-01 8.74e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 221 1.04e-03 7.57e-03 0.07470 -0.054900 0.050600 1.60e-01 1.95e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 8.78e-01 9.48e-01 0.07450 -0.071400 -0.021300 6.68e-01 8.98e-01
ENDOGENOUS STEROLS 20 6.95e-01 8.34e-01 0.07400 0.074000 -0.001180 5.67e-01 9.93e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 3.85e-01 5.74e-01 0.07390 -0.072800 -0.012900 2.86e-01 8.50e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 179 5.23e-03 2.66e-02 0.07390 -0.039900 0.062200 3.58e-01 1.52e-01
RHOD GTPASE CYCLE 51 7.64e-01 8.77e-01 0.07360 0.043400 0.059500 5.92e-01 4.63e-01
CILIUM ASSEMBLY 193 1.29e-02 5.27e-02 0.07360 0.072000 -0.015000 8.48e-02 7.20e-01
SIGNALLING TO ERKS 34 7.50e-01 8.66e-01 0.07320 -0.067800 -0.027600 4.94e-01 7.80e-01
RHOQ GTPASE CYCLE 59 1.98e-01 3.65e-01 0.07310 0.065400 -0.032600 3.85e-01 6.66e-01
DEVELOPMENTAL BIOLOGY 828 8.60e-05 1.06e-03 0.07300 0.016100 0.071200 4.34e-01 5.36e-04
REGULATION OF SIGNALING BY CBL 22 7.98e-01 8.99e-01 0.07270 0.020900 0.069700 8.65e-01 5.72e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 9.34e-01 9.73e-01 0.07260 0.059000 0.042300 7.13e-01 7.92e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 9.03e-01 9.62e-01 0.07210 -0.046900 -0.054700 7.03e-01 6.57e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 9.39e-01 9.76e-01 0.07160 0.053400 0.047700 7.29e-01 7.57e-01
VXPX CARGO TARGETING TO CILIUM 19 7.88e-01 8.93e-01 0.07160 0.070500 0.012300 5.95e-01 9.26e-01
VIRAL MESSENGER RNA SYNTHESIS 42 8.25e-01 9.15e-01 0.07100 -0.055000 -0.044800 5.37e-01 6.15e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 7.79e-01 8.88e-01 0.07080 -0.060100 -0.037300 4.85e-01 6.65e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 2.39e-01 4.18e-01 0.07050 -0.070500 -0.002140 2.41e-01 9.72e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.95e-01 9.58e-01 0.07040 0.066200 0.023900 6.79e-01 8.81e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 5.66e-01 7.38e-01 0.07000 -0.056700 0.041100 6.53e-01 7.44e-01
DISEASES OF IMMUNE SYSTEM 27 6.23e-01 7.78e-01 0.06950 0.005390 -0.069300 9.61e-01 5.33e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 1.52e-01 3.05e-01 0.06950 -0.068500 0.011600 2.44e-01 8.44e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 286 7.55e-04 5.92e-03 0.06940 0.034000 -0.060600 3.24e-01 7.85e-02
REDUCTION OF CYTOSOLIC CA LEVELS 11 7.45e-01 8.65e-01 0.06910 0.053800 -0.043400 7.57e-01 8.03e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 6.72e-01 8.16e-01 0.06910 -0.010400 0.068300 9.34e-01 5.88e-01
SHC MEDIATED CASCADE FGFR4 12 8.13e-01 9.08e-01 0.06910 -0.068900 0.005160 6.80e-01 9.75e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 6.91e-01 8.31e-01 0.06770 -0.067600 0.003540 5.75e-01 9.77e-01
RAC3 GTPASE CYCLE 91 7.02e-01 8.37e-01 0.06720 0.047900 0.047100 4.30e-01 4.38e-01
TRIGLYCERIDE BIOSYNTHESIS 10 9.54e-01 9.84e-01 0.06680 -0.055900 -0.036600 7.60e-01 8.41e-01
REGULATION OF FZD BY UBIQUITINATION 19 8.26e-01 9.15e-01 0.06660 0.014100 0.065100 9.15e-01 6.23e-01
INTRAFLAGELLAR TRANSPORT 52 6.30e-01 7.81e-01 0.06640 0.064000 0.017800 4.25e-01 8.25e-01
GAP JUNCTION DEGRADATION 11 7.95e-01 8.98e-01 0.06600 -0.062100 0.022300 7.21e-01 8.98e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 8.83e-01 9.50e-01 0.06510 -0.046400 -0.045800 6.40e-01 6.44e-01
HEMOSTASIS 473 4.73e-03 2.55e-02 0.06490 0.006700 0.064500 8.03e-01 1.65e-02
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 1.03e-01 2.35e-01 0.06480 0.049200 0.042200 3.60e-02 7.23e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 5.82e-01 7.43e-01 0.06470 -0.049000 0.042300 6.84e-01 7.26e-01
ERBB2 REGULATES CELL MOTILITY 14 8.24e-01 9.15e-01 0.06470 0.000746 -0.064700 9.96e-01 6.75e-01
SIGNALING BY EGFR IN CANCER 22 7.21e-01 8.52e-01 0.06450 -0.064400 0.004200 6.01e-01 9.73e-01
CALNEXIN CALRETICULIN CYCLE 26 5.45e-01 7.23e-01 0.06430 -0.044000 0.046900 6.98e-01 6.79e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 8.04e-01 9.02e-01 0.06420 -0.044000 -0.046800 5.53e-01 5.27e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 8.79e-01 9.48e-01 0.06420 -0.016100 -0.062200 9.14e-01 6.77e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 8.25e-01 9.15e-01 0.06390 0.062400 -0.013900 7.20e-01 9.36e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 9.45e-01 9.82e-01 0.06360 0.043700 0.046200 7.62e-01 7.49e-01
OVARIAN TUMOR DOMAIN PROTEASES 37 4.63e-01 6.51e-01 0.06350 -0.056800 0.028500 5.50e-01 7.65e-01
CGMP EFFECTS 15 8.76e-01 9.47e-01 0.06280 0.013600 0.061300 9.27e-01 6.81e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 9.07e-01 9.64e-01 0.06230 0.043100 0.045000 6.88e-01 6.75e-01
METABOLISM OF LIPIDS 614 8.13e-02 2.01e-01 0.06190 -0.052500 -0.032800 2.70e-02 1.67e-01
SIGNALING BY ERBB4 57 4.69e-01 6.55e-01 0.06180 -0.003090 0.061700 9.68e-01 4.21e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 8.52e-01 9.33e-01 0.06140 -0.060900 -0.007800 6.73e-01 9.57e-01
AGGREPHAGY 35 4.95e-01 6.79e-01 0.06130 0.031300 -0.052700 7.49e-01 5.89e-01
RND1 GTPASE CYCLE 38 8.83e-01 9.50e-01 0.06060 0.045800 0.039700 6.25e-01 6.72e-01
METABOLISM OF CARBOHYDRATES 260 1.14e-01 2.49e-01 0.06050 0.012200 0.059300 7.36e-01 1.00e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 32 5.27e-01 7.05e-01 0.06050 -0.050200 0.033800 6.23e-01 7.41e-01
POTENTIAL THERAPEUTICS FOR SARS 77 4.01e-01 5.95e-01 0.05990 -0.000755 0.059900 9.91e-01 3.63e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 9.32e-01 9.73e-01 0.05910 0.022700 0.054500 8.87e-01 7.34e-01
MEMBRANE TRAFFICKING 581 1.54e-01 3.06e-01 0.05890 -0.047100 -0.035400 5.32e-02 1.46e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 8.33e-01 9.21e-01 0.05880 -0.017600 -0.056100 8.72e-01 6.07e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 85 2.11e-01 3.83e-01 0.05850 0.050100 -0.030200 4.25e-01 6.30e-01
SIGNALING BY HEDGEHOG 142 6.51e-01 7.99e-01 0.05840 0.037800 0.044500 4.37e-01 3.61e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 4.46e-01 6.40e-01 0.05820 -0.055200 -0.018700 2.72e-01 7.11e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 102 2.31e-01 4.08e-01 0.05780 -0.056200 0.013300 3.27e-01 8.16e-01
PI 3K CASCADE FGFR3 13 9.61e-01 9.84e-01 0.05660 0.034100 0.045200 8.31e-01 7.78e-01
VESICLE MEDIATED TRANSPORT 613 1.78e-01 3.41e-01 0.05650 -0.043800 -0.035700 6.53e-02 1.33e-01
SIGNALING BY KIT IN DISEASE 20 7.90e-01 8.94e-01 0.05610 -0.055800 0.005740 6.66e-01 9.65e-01
REPRODUCTION 76 5.81e-01 7.43e-01 0.05610 -0.054800 -0.011700 4.09e-01 8.60e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 9.04e-01 9.62e-01 0.05580 -0.021700 -0.051400 8.63e-01 6.83e-01
NERVOUS SYSTEM DEVELOPMENT 553 1.16e-02 4.84e-02 0.05570 0.006710 0.055300 7.88e-01 2.67e-02
PLATELET ADHESION TO EXPOSED COLLAGEN 12 8.24e-01 9.15e-01 0.05510 0.048100 -0.026900 7.73e-01 8.72e-01
GLYCOGEN STORAGE DISEASES 12 8.66e-01 9.43e-01 0.05500 -0.008120 0.054400 9.61e-01 7.44e-01
SCAVENGING BY CLASS A RECEPTORS 14 8.66e-01 9.43e-01 0.05500 -0.054900 0.001650 7.22e-01 9.91e-01
NUCLEAR ENVELOPE BREAKDOWN 49 4.84e-01 6.68e-01 0.05490 -0.050900 0.020600 5.38e-01 8.03e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 9.62e-01 9.84e-01 0.05430 0.042800 0.033500 7.82e-01 8.28e-01
PI 3K CASCADE FGFR4 12 8.78e-01 9.48e-01 0.05390 -0.005400 0.053600 9.74e-01 7.48e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 7.83e-01 8.90e-01 0.05350 -0.053500 0.000375 6.37e-01 9.97e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 8.88e-01 9.53e-01 0.05300 0.004770 0.052800 9.75e-01 7.23e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 8.82e-01 9.50e-01 0.05300 -0.037400 -0.037500 6.41e-01 6.40e-01
GLYCOGEN METABOLISM 25 9.28e-01 9.72e-01 0.05280 0.044200 0.028900 7.02e-01 8.03e-01
SIGNALING BY PDGFR IN DISEASE 20 8.50e-01 9.33e-01 0.05230 0.003220 0.052200 9.80e-01 6.86e-01
SPRY REGULATION OF FGF SIGNALING 16 8.52e-01 9.33e-01 0.05170 -0.051500 0.005200 7.21e-01 9.71e-01
METABOLISM OF STEROIDS 114 2.58e-01 4.42e-01 0.05120 0.049000 -0.014600 3.66e-01 7.88e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 63 7.35e-01 8.56e-01 0.05110 -0.015500 -0.048700 8.32e-01 5.04e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 5.74e-01 7.41e-01 0.05090 -0.020100 0.046800 8.20e-01 5.96e-01
TELOMERE EXTENSION BY TELOMERASE 22 7.32e-01 8.55e-01 0.05090 0.042200 -0.028500 7.32e-01 8.17e-01
RNA POLYMERASE III TRANSCRIPTION 41 7.72e-01 8.83e-01 0.05070 -0.050000 -0.008570 5.80e-01 9.24e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 7.08e-01 8.40e-01 0.05040 0.050400 -0.000709 5.76e-01 9.94e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 8.03e-01 9.02e-01 0.04960 0.038800 -0.030800 7.88e-01 8.31e-01
OXIDATIVE STRESS INDUCED SENESCENCE 77 5.38e-01 7.15e-01 0.04840 -0.001970 0.048300 9.76e-01 4.63e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 56 5.01e-01 6.83e-01 0.04760 -0.026500 0.039500 7.31e-01 6.09e-01
FANCONI ANEMIA PATHWAY 36 9.14e-01 9.67e-01 0.04750 -0.025100 -0.040300 7.95e-01 6.75e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 8.71e-01 9.45e-01 0.04740 -0.037500 0.029000 8.30e-01 8.68e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 9.81e-01 9.90e-01 0.04690 -0.030900 -0.035300 8.65e-01 8.47e-01
ERYTHROPOIETIN ACTIVATES RAS 13 8.54e-01 9.34e-01 0.04680 -0.037600 0.027900 8.14e-01 8.62e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 9.11e-01 9.66e-01 0.04640 -0.028200 -0.036800 7.41e-01 6.66e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 8.45e-01 9.31e-01 0.04550 -0.010000 0.044400 9.40e-01 7.38e-01
SIGNALING BY CSF3 G CSF 29 9.23e-01 9.69e-01 0.04530 -0.040500 -0.020200 7.06e-01 8.51e-01
RAC2 GTPASE CYCLE 88 6.20e-01 7.77e-01 0.04480 0.044500 0.004970 4.71e-01 9.36e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 18 9.10e-01 9.66e-01 0.04460 -0.044200 -0.005970 7.45e-01 9.65e-01
ACYL CHAIN REMODELLING OF PE 17 9.65e-01 9.84e-01 0.04370 -0.037000 -0.023200 7.92e-01 8.68e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 9.48e-01 9.83e-01 0.04350 0.004130 0.043300 9.82e-01 8.13e-01
PI METABOLISM 79 8.26e-01 9.15e-01 0.04350 0.020200 0.038500 7.56e-01 5.55e-01
INSULIN PROCESSING 24 7.89e-01 8.93e-01 0.04330 -0.021100 0.037800 8.58e-01 7.49e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 6.19e-01 7.77e-01 0.04250 0.042400 0.001310 4.97e-01 9.83e-01
SIGNALING BY ACTIVIN 12 8.99e-01 9.61e-01 0.04190 -0.017300 0.038100 9.17e-01 8.19e-01
REGULATION OF TP53 ACTIVITY 154 4.64e-01 6.51e-01 0.04170 -0.003250 -0.041600 9.45e-01 3.73e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.18e-01 9.69e-01 0.04130 -0.040800 -0.006670 7.52e-01 9.59e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 9.53e-01 9.84e-01 0.04110 0.025000 0.032700 8.13e-01 7.57e-01
MAPK FAMILY SIGNALING CASCADES 289 5.22e-01 7.02e-01 0.04010 -0.036300 -0.017000 2.89e-01 6.19e-01
SURFACTANT METABOLISM 16 8.73e-01 9.46e-01 0.04000 -0.019900 0.034700 8.91e-01 8.10e-01
DNA DOUBLE STRAND BREAK RESPONSE 51 9.17e-01 9.69e-01 0.03990 0.021800 0.033400 7.88e-01 6.80e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 286 5.75e-01 7.41e-01 0.03970 -0.034900 -0.019000 3.11e-01 5.82e-01
RHOG GTPASE CYCLE 74 9.08e-01 9.65e-01 0.03890 0.027800 0.027100 6.79e-01 6.87e-01
NOD1 2 SIGNALING PATHWAY 35 8.05e-01 9.02e-01 0.03890 0.007100 -0.038200 9.42e-01 6.96e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 9.46e-01 9.82e-01 0.03870 0.003820 -0.038500 9.83e-01 8.33e-01
TRANSPORT OF SMALL MOLECULES 587 6.88e-02 1.80e-01 0.03780 -0.000411 0.037800 9.86e-01 1.19e-01
HIV ELONGATION ARREST AND RECOVERY 32 8.39e-01 9.26e-01 0.03760 -0.005050 0.037200 9.61e-01 7.16e-01
CELLULAR SENESCENCE 140 3.51e-01 5.38e-01 0.03730 -0.019900 0.031500 6.84e-01 5.20e-01
CARNITINE METABOLISM 14 9.49e-01 9.83e-01 0.03700 -0.004020 -0.036800 9.79e-01 8.12e-01
GOLGI TO ER RETROGRADE TRANSPORT 119 6.70e-01 8.15e-01 0.03670 -0.005800 -0.036300 9.13e-01 4.95e-01
SIGNALING BY HIPPO 20 9.34e-01 9.73e-01 0.03650 0.036100 0.005370 7.80e-01 9.67e-01
RHOF GTPASE CYCLE 41 7.49e-01 8.66e-01 0.03600 -0.019800 0.030100 8.27e-01 7.39e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 5.90e-01 7.51e-01 0.03600 0.016400 -0.032000 8.01e-01 6.23e-01
SIGNALING BY VEGF 104 8.51e-01 9.33e-01 0.03560 -0.031200 -0.017300 5.83e-01 7.61e-01
SIGNALING BY ERBB2 IN CANCER 25 9.73e-01 9.87e-01 0.03540 -0.025800 -0.024200 8.23e-01 8.34e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 9.56e-01 9.84e-01 0.03530 -0.025400 -0.024500 7.76e-01 7.84e-01
EPH EPHRIN SIGNALING 92 5.27e-01 7.05e-01 0.03520 -0.023900 0.025900 6.92e-01 6.68e-01
GLUCOSE METABOLISM 81 9.18e-01 9.69e-01 0.03490 -0.024500 -0.024900 7.03e-01 6.99e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 9.66e-01 9.84e-01 0.03470 0.030500 0.016600 8.00e-01 8.91e-01
EGFR DOWNREGULATION 28 9.22e-01 9.69e-01 0.03390 -0.033500 -0.005270 7.59e-01 9.62e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 9.60e-01 9.84e-01 0.03360 -0.031100 -0.012800 7.96e-01 9.15e-01
STRIATED MUSCLE CONTRACTION 28 9.67e-01 9.84e-01 0.03310 0.028100 0.017600 7.97e-01 8.72e-01
SIGNALING BY FGFR3 35 9.64e-01 9.84e-01 0.03280 0.019400 0.026500 8.42e-01 7.87e-01
NUCLEOTIDE SALVAGE 21 8.92e-01 9.57e-01 0.03280 -0.013600 0.029800 9.14e-01 8.13e-01
NUCLEAR IMPORT OF REV PROTEIN 32 9.65e-01 9.84e-01 0.03270 -0.018100 -0.027300 8.59e-01 7.90e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 9.01e-01 9.62e-01 0.03270 -0.001600 0.032700 9.88e-01 7.65e-01
SUMOYLATION 162 6.31e-01 7.81e-01 0.03260 -0.032400 -0.003870 4.77e-01 9.32e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 368 1.37e-01 2.85e-01 0.03150 -0.024900 0.019200 4.12e-01 5.29e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 7.88e-01 8.93e-01 0.02980 -0.029800 0.000434 6.43e-01 9.95e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 9.52e-01 9.84e-01 0.02980 -0.009610 -0.028200 9.26e-01 7.86e-01
METABOLISM OF VITAMINS AND COFACTORS 153 4.90e-01 6.73e-01 0.02890 -0.021400 0.019400 6.49e-01 6.78e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.61e-01 9.84e-01 0.02860 0.028000 0.005630 8.24e-01 9.64e-01
CELL JUNCTION ORGANIZATION 74 7.18e-01 8.50e-01 0.02820 -0.020000 0.019900 7.66e-01 7.67e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 8.56e-01 9.35e-01 0.02810 -0.026900 -0.008260 6.38e-01 8.85e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 9.58e-01 9.84e-01 0.02700 -0.010100 -0.025000 9.15e-01 7.92e-01
SIGNALING BY FGFR4 33 8.93e-01 9.57e-01 0.02670 -0.009400 0.025000 9.26e-01 8.04e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 9.27e-01 9.72e-01 0.02670 -0.000663 -0.026600 9.95e-01 7.88e-01
FRS MEDIATED FGFR3 SIGNALING 15 9.89e-01 9.94e-01 0.02660 0.021900 0.015100 8.83e-01 9.19e-01
SHC MEDIATED CASCADE FGFR3 13 9.74e-01 9.87e-01 0.02450 -0.024500 0.000455 8.78e-01 9.98e-01
FRS MEDIATED FGFR4 SIGNALING 14 9.58e-01 9.84e-01 0.02390 -0.012800 0.020200 9.34e-01 8.96e-01
HEDGEHOG OFF STATE 107 9.18e-01 9.69e-01 0.02290 -0.008910 -0.021100 8.73e-01 7.07e-01
SYNTHESIS OF PC 27 9.66e-01 9.84e-01 0.02250 0.003430 0.022300 9.75e-01 8.41e-01
INTEGRIN CELL SURFACE INTERACTIONS 74 8.85e-01 9.51e-01 0.02180 0.001140 -0.021800 9.87e-01 7.46e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 9.78e-01 9.89e-01 0.02170 0.013500 0.017000 8.66e-01 8.32e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 9.86e-01 9.92e-01 0.02170 -0.014300 -0.016300 8.87e-01 8.71e-01
RECYCLING PATHWAY OF L1 40 9.84e-01 9.92e-01 0.02110 -0.014100 -0.015700 8.77e-01 8.63e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 9.75e-01 9.87e-01 0.02070 -0.001250 -0.020700 9.92e-01 8.73e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 9.72e-01 9.87e-01 0.02050 -0.002950 -0.020300 9.79e-01 8.58e-01
REGULATION OF PTEN GENE TRANSCRIPTION 59 9.30e-01 9.72e-01 0.02010 -0.020100 -0.000773 7.90e-01 9.92e-01
SIGNALING BY PTK6 50 9.20e-01 9.69e-01 0.01950 -0.004760 0.018900 9.54e-01 8.17e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 467 4.20e-01 6.13e-01 0.01940 -0.017600 0.008100 5.16e-01 7.65e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 44 9.73e-01 9.87e-01 0.01880 0.017800 0.006120 8.38e-01 9.44e-01
PI3K AKT SIGNALING IN CANCER 90 9.02e-01 9.62e-01 0.01810 0.001010 -0.018100 9.87e-01 7.67e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 9.50e-01 9.83e-01 0.01750 -0.016800 0.004960 8.60e-01 9.58e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 9.92e-01 9.95e-01 0.01700 -0.008600 -0.014600 9.42e-01 9.01e-01
NUCLEOBASE CATABOLISM 31 9.62e-01 9.84e-01 0.01660 -0.015900 0.004640 8.78e-01 9.64e-01
GENE SILENCING BY RNA 81 9.23e-01 9.69e-01 0.01560 -0.002670 0.015400 9.67e-01 8.11e-01
HCMV EARLY EVENTS 79 9.50e-01 9.83e-01 0.01550 0.001860 0.015400 9.77e-01 8.13e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 9.92e-01 9.95e-01 0.01450 -0.002170 -0.014300 9.88e-01 9.23e-01
SIGNALING BY WNT IN CANCER 31 9.86e-01 9.92e-01 0.01440 0.014000 0.003130 8.92e-01 9.76e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 9.35e-01 9.73e-01 0.01420 -0.010400 0.009700 8.90e-01 8.97e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.80e-01 9.90e-01 0.01410 -0.013100 0.005250 9.17e-01 9.67e-01
INTRA GOLGI TRAFFIC 43 9.81e-01 9.90e-01 0.01370 0.002780 0.013500 9.75e-01 8.79e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 9.82e-01 9.90e-01 0.01280 0.000704 -0.012800 9.94e-01 9.00e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 9.64e-01 9.84e-01 0.01260 -0.005930 -0.011100 8.90e-01 7.94e-01
GLYCOLYSIS 67 9.70e-01 9.86e-01 0.01120 0.001010 -0.011200 9.89e-01 8.74e-01
LDL CLEARANCE 16 9.97e-01 9.97e-01 0.01040 0.003320 0.009820 9.82e-01 9.46e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.94e-01 9.96e-01 0.00970 0.009550 -0.001690 9.49e-01 9.91e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 9.91e-01 9.95e-01 0.00843 0.001930 0.008200 9.80e-01 9.13e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.96e-01 9.97e-01 0.00731 0.007000 0.002110 9.44e-01 9.83e-01


Detailed Gene set reports


ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
metric value
setSize 10
pMANOVA 0.000691
p.adjustMANOVA 0.0056
s.dist 0.892
s.LPS -0.692
s.OVA -0.563
p.LPS 0.000151
p.OVA 0.00205



Top 20 genes
Gene LPS OVA
Hbb-bt -7984 -6858
Cyb5r4 -7555 -6592
Cyb5r1 -5407 -7197
Cyb5r2 -6099 -5991
Hba-a1 -6310 -5782
Car2 -4703 -6538
Hba-a2 -5246 -4772
Aqp1 -8362 -2534
Car4 -6781 -2774

Click HERE to show all gene set members

All member genes
LPS OVA
Aqp1 -8362 -2534
Car2 -4703 -6538
Car4 -6781 -2774
Cyb5r1 -5407 -7197
Cyb5r2 -6099 -5991
Cyb5r4 -7555 -6592
Cyb5rl 1417 5649
Hba-a1 -6310 -5782
Hba-a2 -5246 -4772
Hbb-bt -7984 -6858



ADENYLATE CYCLASE ACTIVATING PATHWAY
ADENYLATE CYCLASE ACTIVATING PATHWAY
metric value
setSize 10
pMANOVA 0.000883
p.adjustMANOVA 0.00662
s.dist 0.84
s.LPS 0.684
s.OVA 0.486
p.LPS 0.000178
p.OVA 0.00773



Top 20 genes
Gene LPS OVA
Adcy6 8623 8731
Adcy4 8611 7835
Adcy5 7312 7929
Adcy2 5999 7603
Adcy8 7065 3796
Adcy3 5425 4733
Adcy7 5310 4417
Adcy9 5437 3900

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 3242 -373
Adcy2 5999 7603
Adcy3 5425 4733
Adcy4 8611 7835
Adcy5 7312 7929
Adcy6 8623 8731
Adcy7 5310 4417
Adcy8 7065 3796
Adcy9 5437 3900
Gnal 4536 -1530



REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
metric value
setSize 17
pMANOVA 3.39e-05
p.adjustMANOVA 0.000539
s.dist 0.833
s.LPS 0.564
s.OVA 0.613
p.LPS 5.59e-05
p.OVA 1.22e-05



Top 20 genes
Gene LPS OVA
Ago2 8145 8692
Tnrc6b 8543 7735
Ptpn11 7239 9123
Ago3 8555 7712
Mov10 7236 8633
Ago1 6732 7356
Pml 6708 7317
Src 5356 7946
Runx1 5475 7064
Tnrc6a 7944 4596
Cdk6 6503 5234
Tnrc6c 5070 4922
Ccnd2 3326 6842
Ago4 5680 3085
Ccnd3 2193 4964

Click HERE to show all gene set members

All member genes
LPS OVA
Ago1 6732 7356
Ago2 8145 8692
Ago3 8555 7712
Ago4 5680 3085
Cbfb -2813 -1388
Ccnd1 -4841 -1405
Ccnd2 3326 6842
Ccnd3 2193 4964
Cdk6 6503 5234
Mov10 7236 8633
Pml 6708 7317
Ptpn11 7239 9123
Runx1 5475 7064
Src 5356 7946
Tnrc6a 7944 4596
Tnrc6b 8543 7735
Tnrc6c 5070 4922



TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
metric value
setSize 11
pMANOVA 0.00804
p.adjustMANOVA 0.0365
s.dist 0.711
s.LPS -0.515
s.OVA -0.49
p.LPS 0.00309
p.OVA 0.00489



Top 20 genes
Gene LPS OVA
Tlr3 -7449 -8079
Hsp90b1 -6939 -6185
Lgmn -6681 -6288
Ctss -5870 -4490
Ctsk -2418 -6464
Tlr7 -3877 -3983
Ctsl -6194 -2093
Ctsb -5408 -2204
Unc93b1 -977 -1334

Click HERE to show all gene set members

All member genes
LPS OVA
Cnpy3 -3398 3081
Ctsb -5408 -2204
Ctsk -2418 -6464
Ctsl -6194 -2093
Ctss -5870 -4490
Hsp90b1 -6939 -6185
Lgmn -6681 -6288
Tlr3 -7449 -8079
Tlr7 -3877 -3983
Tlr9 3232 -2762
Unc93b1 -977 -1334



YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
metric value
setSize 11
pMANOVA 0.0135
p.adjustMANOVA 0.0543
s.dist 0.669
s.LPS 0.452
s.OVA 0.493
p.LPS 0.00938
p.OVA 0.00461



Top 20 genes
Gene LPS OVA
Hipk2 8642 8910
Tead2 8314 8339
Hipk1 7537 8997
Tead3 8065 7858
Tead1 7086 7283
Yap1 6513 6848
Runx2 6455 6572
Tead4 1771 5778
Ccn2 1395 3360

Click HERE to show all gene set members

All member genes
LPS OVA
Ccn2 1395 3360
Hipk1 7537 8997
Hipk2 8642 8910
Kat2b -7862 -4866
Runx2 6455 6572
Tead1 7086 7283
Tead2 8314 8339
Tead3 8065 7858
Tead4 1771 5778
Wwtr1 -2195 -6681
Yap1 6513 6848



SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
metric value
setSize 29
pMANOVA 2.62e-05
p.adjustMANOVA 0.000459
s.dist 0.643
s.LPS -0.48
s.OVA -0.428
p.LPS 7.65e-06
p.OVA 6.59e-05



Top 20 genes
Gene LPS OVA
Ube2w -8315 -8028
Ube2g1 -8258 -7970
Ube2b -7903 -8069
Uchl3 -7999 -7873
Ube2a -7882 -7972
Ube2d1 -8182 -7638
Ube2l3 -7792 -7725
Ube2e1 -7934 -7580
Ube2e3 -8312 -7182
Ube2d2a -7662 -7346
Ube2k -7766 -7055
Ube2q2 -8139 -6063
Cdc34 -4441 -4998
Uba6 -3368 -6451
Ube2t -3498 -6148
Ube2s -4618 -3397
Ube2r2 -5498 -2038
Ubb -4190 -2004
Rps27a -4093 -1700
Usp9x -2399 -2822

Click HERE to show all gene set members

All member genes
LPS OVA
Cdc34 -4441 -4998
Otulin -4492 777
Rps27a -4093 -1700
Uba1 4427 2514
Uba52 3635 5396
Uba6 -3368 -6451
Ubb -4190 -2004
Ubc 3430 796
Ube2a -7882 -7972
Ube2b -7903 -8069
Ube2d1 -8182 -7638
Ube2d2a -7662 -7346
Ube2e1 -7934 -7580
Ube2e3 -8312 -7182
Ube2g1 -8258 -7970
Ube2g2 2714 5998
Ube2h 2238 7258
Ube2k -7766 -7055
Ube2l3 -7792 -7725
Ube2q2 -8139 -6063
Ube2r2 -5498 -2038
Ube2s -4618 -3397
Ube2t -3498 -6148
Ube2w -8315 -8028
Ube2z -1170 3097
Uchl3 -7999 -7873
Usp5 2210 3518
Usp7 2945 -1283
Usp9x -2399 -2822



INTERACTION BETWEEN L1 AND ANKYRINS
INTERACTION BETWEEN L1 AND ANKYRINS
metric value
setSize 27
pMANOVA 2.13e-05
p.adjustMANOVA 0.000385
s.dist 0.632
s.LPS 0.515
s.OVA 0.366
p.LPS 3.56e-06
p.OVA 0.000982



Top 20 genes
Gene LPS OVA
Sptbn4 8842 8035
Sptbn5 8320 7875
Nfasc 8775 7144
Kcnq2 8357 6977
Ank2 8278 7016
Scn5a 6334 8244
Sptbn1 6532 7595
Scn2b 6073 7859
Sptbn2 6656 6182
Sptan1 6676 4895
L1cam 6436 4998
Sptb 6810 4354
Scn3a 3353 7267
Scn7a 3924 4911
Scn3b 2205 7442
Scn9a 5326 2500
Ank3 7547 1741
Kcnq3 2086 6289
Scn2a 2449 4433
Scn8a 8069 872

Click HERE to show all gene set members

All member genes
LPS OVA
Actb -2602 1802
Actg1 -6150 -4793
Ank1 6583 291
Ank2 8278 7016
Ank3 7547 1741
Kcnq2 8357 6977
Kcnq3 2086 6289
L1cam 6436 4998
Nfasc 8775 7144
Nrcam 3424 499
Scn1a 1572 -5297
Scn1b -2515 -5587
Scn2a 2449 4433
Scn2b 6073 7859
Scn3a 3353 7267
Scn3b 2205 7442
Scn4b 3409 -4530
Scn5a 6334 8244
Scn7a 3924 4911
Scn8a 8069 872
Scn9a 5326 2500
Sptan1 6676 4895
Sptb 6810 4354
Sptbn1 6532 7595
Sptbn2 6656 6182
Sptbn4 8842 8035
Sptbn5 8320 7875



DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
metric value
setSize 20
pMANOVA 0.00134
p.adjustMANOVA 0.00927
s.dist 0.618
s.LPS 0.426
s.OVA 0.447
p.LPS 0.000973
p.OVA 0.000534



Top 20 genes
Gene LPS OVA
Cspg4 8267 8621
Ncan 7976 8753
Sdc4 7789 8958
Gpc4 6740 7798
Gpc3 5277 9071
Hspg2 4340 7461
Sdc3 4364 5949
B4galt7 2973 7393
Agrn 7616 2407
Vcan 3989 4193
Gpc2 7891 1773
Gpc1 4299 3212
Bgn 3995 1784
Dcn 235 5093

Click HERE to show all gene set members

All member genes
LPS OVA
Agrn 7616 2407
B4galt7 2973 7393
Bcan 7183 -608
Bgn 3995 1784
Cspg4 8267 8621
Cspg5 -573 4123
Dcn 235 5093
Gpc1 4299 3212
Gpc2 7891 1773
Gpc3 5277 9071
Gpc4 6740 7798
Gpc5 -311 5853
Gpc6 1254 -2605
Hspg2 4340 7461
Ncan 7976 8753
Sdc1 -59 -1194
Sdc2 -4691 -739
Sdc3 4364 5949
Sdc4 7789 8958
Vcan 3989 4193



P75NTR REGULATES AXONOGENESIS
P75NTR REGULATES AXONOGENESIS
metric value
setSize 10
pMANOVA 0.0397
p.adjustMANOVA 0.125
s.dist 0.611
s.LPS -0.439
s.OVA -0.424
p.LPS 0.0162
p.OVA 0.0201



Top 20 genes
Gene LPS OVA
Mcf2 -7421 -8092
Omg -7589 -7571
Rtn4 -6541 -5943
Rhoa -7489 -5022
Rtn4r -6421 -4815
Ngf -5405 -5689
Mag -1746 -3640

Click HERE to show all gene set members

All member genes
LPS OVA
Arhgdia 2829 8307
Lingo1 -238 242
Mag -1746 -3640
Mcf2 -7421 -8092
Ngf -5405 -5689
Ngfr 4792 779
Omg -7589 -7571
Rhoa -7489 -5022
Rtn4 -6541 -5943
Rtn4r -6421 -4815



A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
metric value
setSize 26
pMANOVA 0.000279
p.adjustMANOVA 0.00283
s.dist 0.592
s.LPS 0.381
s.OVA 0.453
p.LPS 0.000763
p.OVA 6.46e-05



Top 20 genes
Gene LPS OVA
Cspg4 8267 8621
Ncan 7976 8753
Sdc4 7789 8958
Xylt2 6801 8077
Gpc4 6740 7798
Gpc3 5277 9071
Hspg2 4340 7461
B3gat1 5121 5292
Sdc3 4364 5949
B4galt7 2973 7393
Agrn 7616 2407
Vcan 3989 4193
Gpc2 7891 1773
Gpc1 4299 3212
Xylt1 2328 3951
Bgn 3995 1784
B3gat2 268 6099
Dcn 235 5093
B3galt6 285 3870

Click HERE to show all gene set members

All member genes
LPS OVA
Agrn 7616 2407
B3galt6 285 3870
B3gat1 5121 5292
B3gat2 268 6099
B3gat3 -1269 63
B4galt7 2973 7393
Bcan 7183 -608
Bgn 3995 1784
Cspg4 8267 8621
Cspg5 -573 4123
Dcn 235 5093
Gpc1 4299 3212
Gpc2 7891 1773
Gpc3 5277 9071
Gpc4 6740 7798
Gpc5 -311 5853
Gpc6 1254 -2605
Hspg2 4340 7461
Ncan 7976 8753
Sdc1 -59 -1194
Sdc2 -4691 -739
Sdc3 4364 5949
Sdc4 7789 8958
Vcan 3989 4193
Xylt1 2328 3951
Xylt2 6801 8077



MITOCHONDRIAL TRANSLATION
MITOCHONDRIAL TRANSLATION
metric value
setSize 93
pMANOVA 9.33e-13
p.adjustMANOVA 2.19e-10
s.dist 0.586
s.LPS -0.401
s.OVA -0.428
p.LPS 2.46e-11
p.OVA 9.59e-13



Top 20 genes
Gene LPS OVA
Mrpl1 -8332 -7395
Mrps30 -8013 -7355
Mrpl16 -8131 -7210
Mrpl50 -8272 -7011
Mrpl3 -7473 -7391
Mrps31 -7948 -6779
Mrps22 -7510 -7174
Mrpl47 -7010 -7669
Mrpl32 -7188 -7450
Mrps2 -6729 -7631
Mrpl40 -7742 -6603
Mrpl10 -7817 -5899
Mrpl22 -6850 -6660
Ptcd3 -5493 -7906
Mrps23 -7130 -5647
Mrpl42 -5122 -7408
Mrps14 -6331 -5984
Mtif2 -4838 -7674
Mrpl15 -5853 -5889
Chchd1 -5251 -6016

Click HERE to show all gene set members

All member genes
LPS OVA
Aurkaip1 382 -326
Chchd1 -5251 -6016
Dap3 5442 5192
Eral1 3143 4297
Gadd45gip1 -3587 -2264
Gfm1 3879 -4679
Gfm2 6876 -3116
Mrpl1 -8332 -7395
Mrpl10 -7817 -5899
Mrpl11 -4924 -5386
Mrpl12 -3189 -4641
Mrpl13 -5777 -5369
Mrpl14 -653 1661
Mrpl15 -5853 -5889
Mrpl16 -8131 -7210
Mrpl17 -6185 -2813
Mrpl18 -3671 -6951
Mrpl19 -3128 -1963
Mrpl2 -2554 1097
Mrpl20 -3178 -3414
Mrpl21 -2932 -4869
Mrpl22 -6850 -6660
Mrpl23 -2024 -195
Mrpl24 -1551 -680
Mrpl27 -5368 -3578
Mrpl28 -3288 -2370
Mrpl3 -7473 -7391
Mrpl30 -5439 -4642
Mrpl32 -7188 -7450
Mrpl33 -5018 -4162
Mrpl34 -5588 -5540
Mrpl35 -2834 -5771
Mrpl36 -1409 -4509
Mrpl37 400 -3370
Mrpl38 2946 4157
Mrpl39 -4968 -4551
Mrpl4 5854 -1320
Mrpl40 -7742 -6603
Mrpl41 -1974 -517
Mrpl42 -5122 -7408
Mrpl43 -3277 -3960
Mrpl44 -3798 -2096
Mrpl46 -4624 -4624
Mrpl47 -7010 -7669
Mrpl48 -5040 -4768
Mrpl49 -5379 -3481
Mrpl50 -8272 -7011
Mrpl51 -3017 -4649
Mrpl52 -2854 -964
Mrpl53 -1916 -1754
Mrpl54 -3528 -2886
Mrpl55 -1634 -1841
Mrpl57 -5269 -1551
Mrpl58 -1605 -784
Mrpl9 -4919 -1671
Mrps10 -3515 -3241
Mrps11 -100 -1376
Mrps12 -2663 -3739
Mrps14 -6331 -5984
Mrps15 -2921 -422
Mrps16 -3083 -817
Mrps17 -4494 -543
Mrps18a -3199 -4354
Mrps18b -3829 -3630
Mrps18c -5078 -4277
Mrps2 -6729 -7631
Mrps21 -790 -2962
Mrps22 -7510 -7174
Mrps23 -7130 -5647
Mrps24 -2200 -1695
Mrps25 -3009 -1205
Mrps26 -3517 973
Mrps27 -3927 -4309
Mrps28 -3412 -146
Mrps30 -8013 -7355
Mrps31 -7948 -6779
Mrps33 -4102 -4438
Mrps34 381 1904
Mrps35 1562 -4370
Mrps36 -4562 -5019
Mrps5 -159 1304
Mrps6 681 968
Mrps7 -2487 -2231
Mrps9 -2461 -2976
Mrrf -4390 -6718
Mtfmt 5005 648
Mtif2 -4838 -7674
Mtif3 -3783 -259
Mtrf1l 5572 6377
Oxa1l -4482 -2531
Ptcd3 -5493 -7906
Tsfm -4277 -828
Tufm 4140 586



LGI ADAM INTERACTIONS
LGI ADAM INTERACTIONS
metric value
setSize 14
pMANOVA 0.0104
p.adjustMANOVA 0.0446
s.dist 0.583
s.LPS 0.466
s.OVA 0.351
p.LPS 0.00253
p.OVA 0.0232



Top 20 genes
Gene LPS OVA
Cacng8 7714 8209
Stx1a 6671 9048
Cacng4 6361 9031
Dlg4 6137 8966
Stx1b 7548 6447
Cacng3 5146 7316
Adam22 7855 4031
Lgi2 7067 2146
Cacng2 3127 3228
Adam11 7422 442

Click HERE to show all gene set members

All member genes
LPS OVA
Adam11 7422 442
Adam22 7855 4031
Adam23 1626 -4306
Cacng2 3127 3228
Cacng3 5146 7316
Cacng4 6361 9031
Cacng8 7714 8209
Dlg4 6137 8966
Lgi1 -6303 -6477
Lgi2 7067 2146
Lgi3 4196 -2981
Lgi4 -4723 4356
Stx1a 6671 9048
Stx1b 7548 6447



NOTCH HLH TRANSCRIPTION PATHWAY
NOTCH HLH TRANSCRIPTION PATHWAY
metric value
setSize 28
pMANOVA 0.000229
p.adjustMANOVA 0.00247
s.dist 0.572
s.LPS 0.361
s.OVA 0.444
p.LPS 0.000945
p.OVA 4.75e-05



Top 20 genes
Gene LPS OVA
Hdac5 8807 8988
Notch1 8723 8906
Ncor2 8757 8740
Notch3 8800 8651
Notch4 8782 8588
Hdac6 8730 7720
Crebbp 8424 7860
Ncor1 7488 8678
Hdac8 7523 8536
Notch2 6571 8552
Hdac4 6828 8194
Hdac11 4235 7904
Mamld1 4136 7045
Maml3 4129 5198
Hdac10 4261 4630
Maml2 1674 6068
Hdac7 6270 1598
Maml1 1126 4715
Tbl1x 326 2469

Click HERE to show all gene set members

All member genes
LPS OVA
Crebbp 8424 7860
Hdac1 -3685 1716
Hdac10 4261 4630
Hdac11 4235 7904
Hdac2 -7008 -6870
Hdac3 2501 -6263
Hdac4 6828 8194
Hdac5 8807 8988
Hdac6 8730 7720
Hdac7 6270 1598
Hdac8 7523 8536
Hdac9 -715 588
Kat2a 6283 -241
Kat2b -7862 -4866
Maml1 1126 4715
Maml2 1674 6068
Maml3 4129 5198
Mamld1 4136 7045
Ncor1 7488 8678
Ncor2 8757 8740
Notch1 8723 8906
Notch2 6571 8552
Notch3 8800 8651
Notch4 8782 8588
Rbpj -3065 2946
Snw1 -3472 1223
Tbl1x 326 2469
Tbl1xr1 -4303 124



CRISTAE FORMATION
CRISTAE FORMATION
metric value
setSize 31
pMANOVA 0.000174
p.adjustMANOVA 0.00198
s.dist 0.569
s.LPS -0.397
s.OVA -0.407
p.LPS 0.000129
p.OVA 8.93e-05



Top 20 genes
Gene LPS OVA
Apoo -8100 -8090
Atp5c1 -8037 -7922
Mtx2 -7995 -7767
Atp5pb -7461 -7713
Dmac2l -7240 -7929
Apool -5490 -6608
Atp5o -4665 -6182
Atp5l -4651 -6088
Atp5h -4779 -5494
Atp5b -4851 -5411
Chchd3 -4604 -5339
mt-Atp6 -5036 -4677
Immt -3504 -5186
Atp5g3 -4427 -3685
Atp5a1 -4471 -3464
Micos10 -3119 -4040
Hspa9 -3313 -2549
Micos13 -2546 -2851
Tmem11 -3442 -2107
Atp5j2 -1499 -2317

Click HERE to show all gene set members

All member genes
LPS OVA
Apoo -8100 -8090
Apool -5490 -6608
Atp5a1 -4471 -3464
Atp5b -4851 -5411
Atp5c1 -8037 -7922
Atp5d 317 -1642
Atp5e -1106 1068
Atp5g1 1338 397
Atp5g2 -3032 799
Atp5g3 -4427 -3685
Atp5h -4779 -5494
Atp5j -1090 -1384
Atp5j2 -1499 -2317
Atp5k 2028 2298
Atp5l -4651 -6088
Atp5o -4665 -6182
Atp5pb -7461 -7713
Chchd3 -4604 -5339
Chchd6 -3269 -299
Dmac2l -7240 -7929
Dnajc11 3652 2915
Hspa9 -3313 -2549
Immt -3504 -5186
Micos10 -3119 -4040
Micos13 -2546 -2851
mt-Atp6 -5036 -4677
mt-Atp8 7207 8276
Mtx1 -5695 280
Mtx2 -7995 -7767
Samm50 893 145
Tmem11 -3442 -2107



SIGNALING BY LEPTIN
SIGNALING BY LEPTIN
metric value
setSize 10
pMANOVA 0.0614
p.adjustMANOVA 0.169
s.dist 0.568
s.LPS 0.402
s.OVA 0.402
p.LPS 0.0279
p.OVA 0.0277



Top 20 genes
Gene LPS OVA
Sh2b1 8661 8118
Stat3 7738 8756
Ptpn11 7239 9123
Stat5b 5496 8178
Irs2 3199 2929
Irs1 3396 1941
Socs3 2037 1326

Click HERE to show all gene set members

All member genes
LPS OVA
Irs1 3396 1941
Irs2 3199 2929
Jak2 -2164 416
Lepr -2518 33
Ptpn11 7239 9123
Sh2b1 8661 8118
Socs3 2037 1326
Stat3 7738 8756
Stat5a 4106 -1051
Stat5b 5496 8178



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 0.00596
p.adjustMANOVA 0.0292
s.dist 0.559
s.LPS -0.392
s.OVA -0.398
p.LPS 0.00312
p.OVA 0.00265



Top 20 genes
Gene LPS OVA
Cct6a -7914 -6765
Tcp1 -7345 -6683
Cct4 -7394 -6475
Tuba1c -7888 -4804
Cct2 -6928 -5364
Tuba8 -4954 -7089
Cct7 -5812 -5407
Tuba4a -3770 -6670
Cct8 -5432 -4461
Tuba1b -4407 -5454
Cct5 -5831 -3367
Tubb4b -2612 -6316
Cct3 -2849 -1055

Click HERE to show all gene set members

All member genes
LPS OVA
Cct2 -6928 -5364
Cct3 -2849 -1055
Cct4 -7394 -6475
Cct5 -5831 -3367
Cct6a -7914 -6765
Cct7 -5812 -5407
Cct8 -5432 -4461
Tcp1 -7345 -6683
Tuba1a -1706 673
Tuba1b -4407 -5454
Tuba1c -7888 -4804
Tuba4a -3770 -6670
Tuba8 -4954 -7089
Tubb2a 873 5474
Tubb2b 4228 6173
Tubb3 479 -3807
Tubb4a 4650 971
Tubb4b -2612 -6316
Tubb6 5452 5011



CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
metric value
setSize 20
pMANOVA 0.00271
p.adjustMANOVA 0.0164
s.dist 0.554
s.LPS -0.444
s.OVA -0.332
p.LPS 0.000587
p.OVA 0.0102



Top 20 genes
Gene LPS OVA
Pex3 -8009 -7909
Atad1 -8302 -7541
Acbd5 -7580 -8017
Abcd2 -7475 -8106
Pex13 -7478 -7062
Gdap1 -6665 -7063
Slc25a17 -7761 -5758
Pex2 -7282 -5276
Pex11b -6323 -3422
Aldh3a2 -3285 -3909
Abcd3 -3406 -3045
Pex19 -2625 -1036
Fis1 -2107 -421

Click HERE to show all gene set members

All member genes
LPS OVA
Abcd1 7794 5025
Abcd2 -7475 -8106
Abcd3 -3406 -3045
Acbd5 -7580 -8017
Aldh3a2 -3285 -3909
Atad1 -8302 -7541
Fis1 -2107 -421
Gdap1 -6665 -7063
Pex11b -6323 -3422
Pex12 169 -2809
Pex13 -7478 -7062
Pex14 -2337 3350
Pex16 954 3535
Pex19 -2625 -1036
Pex2 -7282 -5276
Pex26 2503 5761
Pex3 -8009 -7909
Pxmp2 -993 5070
Pxmp4 -1078 1760
Slc25a17 -7761 -5758



RUNX3 REGULATES NOTCH SIGNALING
RUNX3 REGULATES NOTCH SIGNALING
metric value
setSize 13
pMANOVA 0.0183
p.adjustMANOVA 0.0701
s.dist 0.552
s.LPS 0.316
s.OVA 0.452
p.LPS 0.0484
p.OVA 0.00473



Top 20 genes
Gene LPS OVA
Jag1 8700 8954
Notch1 8723 8906
Crebbp 8424 7860
Hes1 5503 5621
Mamld1 4136 7045
Maml3 4129 5198
Ep300 4474 3914
Maml2 1674 6068
Maml1 1126 4715

Click HERE to show all gene set members

All member genes
LPS OVA
Crebbp 8424 7860
Ep300 4474 3914
Hes1 5503 5621
Jag1 8700 8954
Kat2a 6283 -241
Kat2b -7862 -4866
Maml1 1126 4715
Maml2 1674 6068
Maml3 4129 5198
Mamld1 4136 7045
Notch1 8723 8906
Rbpj -3065 2946
Snw1 -3472 1223



NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
metric value
setSize 20
pMANOVA 0.000681
p.adjustMANOVA 0.00557
s.dist 0.544
s.LPS 0.263
s.OVA 0.476
p.LPS 0.0421
p.OVA 0.000227



Top 20 genes
Gene LPS OVA
Notch1 8723 8906
Notch4 8782 8588
Crebbp 8424 7860
Notch2 6571 8552
Hes1 5503 5621
Mamld1 4136 7045
Maml3 4129 5198
Hes5 2067 8637
Ep300 4474 3914
Smad3 3233 5308
Flt4 1967 6116
Maml2 1674 6068
Maml1 1126 4715

Click HERE to show all gene set members

All member genes
LPS OVA
Acta2 2963 -2718
Crebbp 8424 7860
Ep300 4474 3914
Flt4 1967 6116
Hes1 5503 5621
Hes5 2067 8637
Hey1 -4134 2963
Hey2 -1116 6442
Kat2a 6283 -241
Kat2b -7862 -4866
Maml1 1126 4715
Maml2 1674 6068
Maml3 4129 5198
Mamld1 4136 7045
Notch1 8723 8906
Notch2 6571 8552
Notch4 8782 8588
Rbpj -3065 2946
Smad3 3233 5308
Snw1 -3472 1223



NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
metric value
setSize 11
pMANOVA 0.00583
p.adjustMANOVA 0.0288
s.dist 0.544
s.LPS 0.206
s.OVA 0.503
p.LPS 0.238
p.OVA 0.00384



Top 20 genes
Gene LPS OVA
Notch2 6571 8552
Hes1 5503 5621
Mamld1 4136 7045
Maml3 4129 5198
Hes5 2067 8637
Ep300 4474 3914
Maml2 1674 6068
Maml1 1126 4715

Click HERE to show all gene set members

All member genes
LPS OVA
Creb1 -4062 -2249
Ep300 4474 3914
Fcer2a -222 2904
Hes1 5503 5621
Hes5 2067 8637
Maml1 1126 4715
Maml2 1674 6068
Maml3 4129 5198
Mamld1 4136 7045
Notch2 6571 8552
Rbpj -3065 2946



PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
metric value
setSize 11
pMANOVA 0.0381
p.adjustMANOVA 0.121
s.dist 0.543
s.LPS 0.445
s.OVA 0.312
p.LPS 0.0107
p.OVA 0.0734



Top 20 genes
Gene LPS OVA
Cacna1b 8070 8050
Cacna1e 7401 8155
Cacng4 6361 9031
Cacnb3 6556 8650
Cacnb1 6046 6746
Cacna2d2 5708 3363
Cacna1a 6581 2430
Cacng2 3127 3228
Cacnb2 919 336

Click HERE to show all gene set members

All member genes
LPS OVA
Cacna1a 6581 2430
Cacna1b 8070 8050
Cacna1e 7401 8155
Cacna2d2 5708 3363
Cacna2d3 421 -7076
Cacnb1 6046 6746
Cacnb2 919 336
Cacnb3 6556 8650
Cacnb4 -6199 -7719
Cacng2 3127 3228
Cacng4 6361 9031



REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
metric value
setSize 10
pMANOVA 0.0567
p.adjustMANOVA 0.159
s.dist 0.542
s.LPS 0.32
s.OVA 0.438
p.LPS 0.0802
p.OVA 0.0166



Top 20 genes
Gene LPS OVA
Slit1 6681 7277
Src 5356 7946
Robo3 6901 4575
Slit2 4634 5347
Dcc 3075 7950
Ntn1 2698 7065
Robo1 4387 3823
Nell2 555 4155

Click HERE to show all gene set members

All member genes
LPS OVA
Dcc 3075 7950
Nell2 555 4155
Ntn1 2698 7065
Robo1 4387 3823
Robo2 -974 -1321
Robo3 6901 4575
Slit1 6681 7277
Slit2 4634 5347
Slit3 -3187 -3988
Src 5356 7946



COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
metric value
setSize 26
pMANOVA 0.00137
p.adjustMANOVA 0.0093
s.dist 0.541
s.LPS -0.393
s.OVA -0.371
p.LPS 0.000525
p.OVA 0.00104



Top 20 genes
Gene LPS OVA
Vbp1 -8222 -7941
Pfdn4 -7352 -7812
Cct6a -7914 -6765
Tcp1 -7345 -6683
Cct4 -7394 -6475
Tuba1c -7888 -4804
Cct2 -6928 -5364
Tuba8 -4954 -7089
Cct7 -5812 -5407
Tuba4a -3770 -6670
Cct8 -5432 -4461
Tuba1b -4407 -5454
Cct5 -5831 -3367
Tubb4b -2612 -6316
Pfdn1 -4288 -3770
Cct3 -2849 -1055
Pfdn6 -1512 -1692

Click HERE to show all gene set members

All member genes
LPS OVA
Actb -2602 1802
Cct2 -6928 -5364
Cct3 -2849 -1055
Cct4 -7394 -6475
Cct5 -5831 -3367
Cct6a -7914 -6765
Cct7 -5812 -5407
Cct8 -5432 -4461
Pfdn1 -4288 -3770
Pfdn2 3974 3500
Pfdn4 -7352 -7812
Pfdn5 -2047 1518
Pfdn6 -1512 -1692
Tcp1 -7345 -6683
Tuba1a -1706 673
Tuba1b -4407 -5454
Tuba1c -7888 -4804
Tuba4a -3770 -6670
Tuba8 -4954 -7089
Tubb2a 873 5474
Tubb2b 4228 6173
Tubb3 479 -3807
Tubb4a 4650 971
Tubb4b -2612 -6316
Tubb6 5452 5011
Vbp1 -8222 -7941



RESPIRATORY ELECTRON TRANSPORT
RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 102
pMANOVA 8.14e-12
p.adjustMANOVA 9.57e-10
s.dist 0.539
s.LPS -0.384
s.OVA -0.379
p.LPS 2.08e-11
p.OVA 3.94e-11



Top 20 genes
Gene LPS OVA
Ndufaf4 -7519 -7833
Ndufaf1 -7741 -7434
Ndufv2 -7249 -7621
Cycs -6807 -7995
Uqcrc2 -6972 -6909
Coq10b -7479 -6202
Ndufaf5 -6087 -7047
Etfa -6678 -6310
mt-Co2 -5502 -7647
Ndufc2 -6855 -5673
Uqcrfs1 -6258 -6207
Sdhb -6037 -6107
Ndufs4 -6153 -5967
mt-Nd6 -6506 -5628
Ndufb5 -5725 -6212
Etfdh -7099 -4873
Ndufaf2 -5918 -5836
mt-Nd2 -7019 -4749
Ndufs1 -5616 -5621
Sco1 -5121 -6140

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 -677 -2479
Coq10a -2671 -4038
Coq10b -7479 -6202
Cox11 -2194 -880
Cox14 -2675 -4179
Cox16 -3228 -7098
Cox18 -1085 1678
Cox19 1627 1226
Cox20 -1700 -992
Cox4i1 -2475 -2072
Cox5a -4257 -5813
Cox5b 1145 1275
Cox6a1 -2753 -2368
Cox6b1 -3830 -4351
Cox6c -1378 -973
Cox7a2l -4680 -2373
Cox7b -3290 -5544
Cox7c -2917 -2010
Cox8a -1252 2962
Cyc1 -4064 -4417
Cycs -6807 -7995
Ecsit -2855 -793
Etfa -6678 -6310
Etfb -4038 924
Etfdh -7099 -4873
Lrpprc 2465 -2248
mt-Co1 -5610 -2353
mt-Co2 -5502 -7647
mt-Co3 -5094 -5248
mt-Cytb -5465 -3497
mt-Nd1 -5959 -4811
mt-Nd2 -7019 -4749
mt-Nd3 254 4573
mt-Nd4 -6158 -3936
mt-Nd5 -5883 -1884
mt-Nd6 -6506 -5628
Ndufa1 -459 -969
Ndufa10 -4268 -6585
Ndufa11 -3102 -4612
Ndufa12 3432 815
Ndufa13 1608 3366
Ndufa2 -1510 192
Ndufa3 1787 2433
Ndufa4 -3806 -4267
Ndufa5 -1324 -2827
Ndufa6 -550 -726
Ndufa7 -2620 674
Ndufa8 -1960 -884
Ndufa9 -2828 -4058
Ndufab1 -4238 -5872
Ndufaf1 -7741 -7434
Ndufaf2 -5918 -5836
Ndufaf3 -1230 1625
Ndufaf4 -7519 -7833
Ndufaf5 -6087 -7047
Ndufaf6 356 -5560
Ndufaf7 1830 4138
Ndufb1 -1089 287
Ndufb10 -2926 -5205
Ndufb11 -4944 -4741
Ndufb2 -2452 -3682
Ndufb3 -4207 -3444
Ndufb4 -4223 -1829
Ndufb5 -5725 -6212
Ndufb6 -3325 -5439
Ndufb7 -637 523
Ndufb8 -3892 -3600
Ndufb9 -4209 -3192
Ndufc1 -2330 -3138
Ndufc2 -6855 -5673
Ndufs1 -5616 -5621
Ndufs2 -2561 -313
Ndufs3 -4327 -5091
Ndufs4 -6153 -5967
Ndufs5 -2819 -4381
Ndufs6 983 965
Ndufs7 1864 537
Ndufs8 -4519 -6311
Ndufv1 -1537 -1887
Ndufv2 -7249 -7621
Ndufv3 1171 525
Nubpl -7142 -4165
Sco1 -5121 -6140
Sco2 -8317 -39
Sdha -732 1601
Sdhb -6037 -6107
Sdhc -5013 -1446
Sdhd -5538 -2713
Surf1 -4284 -3081
Taco1 748 -2333
Timmdc1 -802 127
Tmem126b -3315 -2415
Tmem186 6860 6728
Trap1 4894 -871
Uqcr10 650 1013
Uqcr11 -113 1026
Uqcrb -3706 -3673
Uqcrc1 -1846 -2145
Uqcrc2 -6972 -6909
Uqcrfs1 -6258 -6207
Uqcrh -4398 -3925
Uqcrq -1275 -45



RORA ACTIVATES GENE EXPRESSION
RORA ACTIVATES GENE EXPRESSION
metric value
setSize 18
pMANOVA 0.00895
p.adjustMANOVA 0.0391
s.dist 0.534
s.LPS 0.416
s.OVA 0.336
p.LPS 0.00226
p.OVA 0.0136



Top 20 genes
Gene LPS OVA
Rxra 7925 8975
Srebf1 7832 8801
Crebbp 8424 7860
Helz2 6331 8331
Chd9 7337 6609
Carm1 6208 4894
Ppara 4274 6027
Ep300 4474 3914
Med1 6682 2440
Ncoa6 5815 2410
Ncoa1 4372 2629
Cpt1a 2845 3112
Ncoa2 2518 1840
Tbl1x 326 2469

Click HERE to show all gene set members

All member genes
LPS OVA
Carm1 6208 4894
Chd9 7337 6609
Cpt1a 2845 3112
Crebbp 8424 7860
Ep300 4474 3914
Helz2 6331 8331
Med1 6682 2440
Ncoa1 4372 2629
Ncoa2 2518 1840
Ncoa6 5815 2410
Ppara 4274 6027
Rora -2339 -7222
Rxra 7925 8975
Smarcd3 1688 -453
Srebf1 7832 8801
Tbl1x 326 2469
Tbl1xr1 -4303 124
Tgs1 -1299 -1455



FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
metric value
setSize 18
pMANOVA 0.012
p.adjustMANOVA 0.0497
s.dist 0.531
s.LPS -0.362
s.OVA -0.389
p.LPS 0.00784
p.OVA 0.00427



Top 20 genes
Gene LPS OVA
Atp5c1 -8037 -7922
Atp5pb -7461 -7713
Dmac2l -7240 -7929
Atp5o -4665 -6182
Atp5l -4651 -6088
Atp5h -4779 -5494
Atp5b -4851 -5411
mt-Atp6 -5036 -4677
Atp5g3 -4427 -3685
Atp5a1 -4471 -3464
Atp5j2 -1499 -2317
Atp5j -1090 -1384

Click HERE to show all gene set members

All member genes
LPS OVA
Atp5a1 -4471 -3464
Atp5b -4851 -5411
Atp5c1 -8037 -7922
Atp5d 317 -1642
Atp5e -1106 1068
Atp5g1 1338 397
Atp5g2 -3032 799
Atp5g3 -4427 -3685
Atp5h -4779 -5494
Atp5j -1090 -1384
Atp5j2 -1499 -2317
Atp5k 2028 2298
Atp5l -4651 -6088
Atp5o -4665 -6182
Atp5pb -7461 -7713
Dmac2l -7240 -7929
mt-Atp6 -5036 -4677
mt-Atp8 7207 8276



ENDOSOMAL VACUOLAR PATHWAY
ENDOSOMAL VACUOLAR PATHWAY
metric value
setSize 10
pMANOVA 0.000802
p.adjustMANOVA 0.00608
s.dist 0.529
s.LPS -0.523
s.OVA -0.0797
p.LPS 0.00416
p.OVA 0.663



Top 20 genes
Gene LPS OVA
B2m -7288 -4890
Ctss -5870 -4490
Ctsl -6194 -2093

Click HERE to show all gene set members

All member genes
LPS OVA
B2m -7288 -4890
Ctsl -6194 -2093
Ctss -5870 -4490
H2-D1 -5796 3219
H2-M3 -6857 900
H2-Q10 701 -6026
H2-Q2 -3124 4476
H2-Q7 -4526 1733
H2-T23 -7957 2465
Lnpep 4412 2969



INTERLEUKIN 6 SIGNALING
INTERLEUKIN 6 SIGNALING
metric value
setSize 10
pMANOVA 0.0859
p.adjustMANOVA 0.207
s.dist 0.529
s.LPS 0.353
s.OVA 0.393
p.LPS 0.0531
p.OVA 0.0312



Top 20 genes
Gene LPS OVA
Stat3 7738 8756
Ptpn11 7239 9123
Cbl 7977 8257
Il6st 7677 8360
Tyk2 7454 5628
Il6ra 1229 6835
Socs3 2037 1326

Click HERE to show all gene set members

All member genes
LPS OVA
Cbl 7977 8257
Il6ra 1229 6835
Il6st 7677 8360
Jak1 -688 -4035
Jak2 -2164 416
Ptpn11 7239 9123
Socs3 2037 1326
Stat1 -5474 -5640
Stat3 7738 8756
Tyk2 7454 5628



PENTOSE PHOSPHATE PATHWAY
PENTOSE PHOSPHATE PATHWAY
metric value
setSize 13
pMANOVA 0.0424
p.adjustMANOVA 0.131
s.dist 0.525
s.LPS -0.393
s.OVA -0.349
p.LPS 0.0142
p.OVA 0.0294



Top 20 genes
Gene LPS OVA
Rpe -7837 -7630
Prps2 -8230 -6888
Rbks -7573 -7308
Pgm2 -6585 -5791
Taldo1 -6827 -4802
Shpk -2509 -5698
G6pdx -1610 -2558

Click HERE to show all gene set members

All member genes
LPS OVA
Dera 1597 -4689
G6pdx -1610 -2558
Pgd 1829 7351
Pgls -212 3998
Pgm2 -6585 -5791
Prps1 -4872 1278
Prps2 -8230 -6888
Rbks -7573 -7308
Rpe -7837 -7630
Rpia 3164 -678
Shpk -2509 -5698
Taldo1 -6827 -4802
Tkt -947 1005



E2F MEDIATED REGULATION OF DNA REPLICATION
E2F MEDIATED REGULATION OF DNA REPLICATION
metric value
setSize 20
pMANOVA 0.00887
p.adjustMANOVA 0.0389
s.dist 0.522
s.LPS -0.357
s.OVA -0.38
p.LPS 0.00571
p.OVA 0.00325



Top 20 genes
Gene LPS OVA
Ppp2cb -8331 -8002
Orc5 -7767 -7983
Orc6 -7734 -7615
Orc4 -7333 -7976
Prim1 -7056 -7108
Ppp2ca -6913 -6550
Cdk1 -6951 -4507
Orc2 -5769 -3287
Rb1 -3725 -4989
Ppp2r1a -4969 -1565
Orc3 -1278 -4858
Pola2 -697 -4282

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk1 -6951 -4507
E2f1 3808 -285
Mcm8 -2227 1086
Orc2 -5769 -3287
Orc3 -1278 -4858
Orc4 -7333 -7976
Orc5 -7767 -7983
Orc6 -7734 -7615
Pola1 3969 -565
Pola2 -697 -4282
Ppp2ca -6913 -6550
Ppp2cb -8331 -8002
Ppp2r1a -4969 -1565
Ppp2r1b 652 3974
Ppp2r3d 3713 5307
Prim1 -7056 -7108
Prim2 -3350 3566
Rb1 -3725 -4989
Tfdp1 5579 3163
Tfdp2 67 -2742



CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
metric value
setSize 11
pMANOVA 0.0752
p.adjustMANOVA 0.191
s.dist 0.521
s.LPS -0.358
s.OVA -0.378
p.LPS 0.0398
p.OVA 0.0299



Top 20 genes
Gene LPS OVA
Ywhaq -8288 -7457
Ywhab -7625 -5338
Cdk1 -6951 -4507
Ywhah -5186 -4941
Ywhae -7269 -3433
Ywhaz -6934 -2917
Wee1 -4175 -3571

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk1 -6951 -4507
Chek1 1163 -6859
Chek2 1384 -1856
Sfn 8393 7211
Wee1 -4175 -3571
Ywhab -7625 -5338
Ywhae -7269 -3433
Ywhag 4405 3478
Ywhah -5186 -4941
Ywhaq -8288 -7457
Ywhaz -6934 -2917



ADENYLATE CYCLASE INHIBITORY PATHWAY
ADENYLATE CYCLASE INHIBITORY PATHWAY
metric value
setSize 13
pMANOVA 0.0472
p.adjustMANOVA 0.142
s.dist 0.519
s.LPS 0.382
s.OVA 0.351
p.LPS 0.0171
p.OVA 0.0285



Top 20 genes
Gene LPS OVA
Adcy6 8623 8731
Adcy4 8611 7835
Adcy5 7312 7929
Adcy2 5999 7603
Adcy8 7065 3796
Adcy3 5425 4733
Adcy7 5310 4417
Adcy9 5437 3900

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 3242 -373
Adcy2 5999 7603
Adcy3 5425 4733
Adcy4 8611 7835
Adcy5 7312 7929
Adcy6 8623 8731
Adcy7 5310 4417
Adcy8 7065 3796
Adcy9 5437 3900
Gnai1 -6416 -5033
Gnai2 -2211 8449
Gnai3 -6774 -4487
Gnal 4536 -1530



NR1H2 AND NR1H3 MEDIATED SIGNALING
NR1H2 AND NR1H3 MEDIATED SIGNALING
metric value
setSize 38
pMANOVA 0.000103
p.adjustMANOVA 0.00125
s.dist 0.517
s.LPS 0.331
s.OVA 0.398
p.LPS 0.000421
p.OVA 2.22e-05



Top 20 genes
Gene LPS OVA
Ncor2 8757 8740
Rxra 7925 8975
Ago2 8145 8692
Srebf1 7832 8801
Tnrc6b 8543 7735
Ago3 8555 7712
Ncor1 7488 8678
Mov10 7236 8633
Kdm4a 7347 7973
Ago1 6732 7356
Fasn 6575 7172
Tnrc6a 7944 4596
Gps2 6079 5945
Tnrc6c 5070 4922
Scd2 3826 6044
Abca1 3301 5622
Ago4 5680 3085
Ep300 4474 3914
Nr1h3 4219 3708
Ncoa1 4372 2629

Click HERE to show all gene set members

All member genes
LPS OVA
Abca1 3301 5622
Abcg1 1532 5200
Ago1 6732 7356
Ago2 8145 8692
Ago3 8555 7712
Ago4 5680 3085
Apoc1 -6072 -830
Apod -6602 -3621
Apoe -96 6584
Arl4c -3095 -2378
Eepd1 750 3960
Ep300 4474 3914
Fasn 6575 7172
Gps2 6079 5945
Hdac3 2501 -6263
Kdm1a -1185 -807
Kdm1b -3826 491
Kdm3a 2418 3216
Kdm4a 7347 7973
Mov10 7236 8633
Mylip 1648 1675
Ncoa1 4372 2629
Ncor1 7488 8678
Ncor2 8757 8740
Nr1h2 4688 -29
Nr1h3 4219 3708
Nrip1 -3031 -5214
Pltp 1193 5678
Rxra 7925 8975
Rxrb -75 2475
Scd1 1053 5810
Scd2 3826 6044
Srebf1 7832 8801
Tbl1x 326 2469
Tbl1xr1 -4303 124
Tnrc6a 7944 4596
Tnrc6b 8543 7735
Tnrc6c 5070 4922



NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
metric value
setSize 32
pMANOVA 0.000467
p.adjustMANOVA 0.00407
s.dist 0.517
s.LPS 0.333
s.OVA 0.395
p.LPS 0.00111
p.OVA 0.00011



Top 20 genes
Gene LPS OVA
Ncor2 8757 8740
Rxra 7925 8975
Ago2 8145 8692
Tnrc6b 8543 7735
Ago3 8555 7712
Ncor1 7488 8678
Mov10 7236 8633
Kdm4a 7347 7973
Ago1 6732 7356
Tnrc6a 7944 4596
Gps2 6079 5945
Tnrc6c 5070 4922
Abca1 3301 5622
Ago4 5680 3085
Ep300 4474 3914
Nr1h3 4219 3708
Ncoa1 4372 2629
Abcg1 1532 5200
Kdm3a 2418 3216
Pltp 1193 5678

Click HERE to show all gene set members

All member genes
LPS OVA
Abca1 3301 5622
Abcg1 1532 5200
Ago1 6732 7356
Ago2 8145 8692
Ago3 8555 7712
Ago4 5680 3085
Apoc1 -6072 -830
Apod -6602 -3621
Apoe -96 6584
Arl4c -3095 -2378
Eepd1 750 3960
Ep300 4474 3914
Gps2 6079 5945
Hdac3 2501 -6263
Kdm1a -1185 -807
Kdm1b -3826 491
Kdm3a 2418 3216
Kdm4a 7347 7973
Mov10 7236 8633
Ncoa1 4372 2629
Ncor1 7488 8678
Ncor2 8757 8740
Nr1h2 4688 -29
Nr1h3 4219 3708
Pltp 1193 5678
Rxra 7925 8975
Rxrb -75 2475
Tbl1x 326 2469
Tbl1xr1 -4303 124
Tnrc6a 7944 4596
Tnrc6b 8543 7735
Tnrc6c 5070 4922



COMPLEX I BIOGENESIS
COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 2.97e-06
p.adjustMANOVA 6.6e-05
s.dist 0.513
s.LPS -0.361
s.OVA -0.365
p.LPS 3.01e-06
p.OVA 2.3e-06



Top 20 genes
Gene LPS OVA
Ndufaf4 -7519 -7833
Ndufaf1 -7741 -7434
Ndufv2 -7249 -7621
Ndufaf5 -6087 -7047
Ndufc2 -6855 -5673
Ndufs4 -6153 -5967
mt-Nd6 -6506 -5628
Ndufb5 -5725 -6212
Ndufaf2 -5918 -5836
mt-Nd2 -7019 -4749
Ndufs1 -5616 -5621
Nubpl -7142 -4165
mt-Nd1 -5959 -4811
Ndufs8 -4519 -6311
Ndufa10 -4268 -6585
Ndufab1 -4238 -5872
mt-Nd4 -6158 -3936
Ndufb11 -4944 -4741
Ndufs3 -4327 -5091
Ndufb6 -3325 -5439

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 -677 -2479
Ecsit -2855 -793
mt-Nd1 -5959 -4811
mt-Nd2 -7019 -4749
mt-Nd3 254 4573
mt-Nd4 -6158 -3936
mt-Nd5 -5883 -1884
mt-Nd6 -6506 -5628
Ndufa1 -459 -969
Ndufa10 -4268 -6585
Ndufa11 -3102 -4612
Ndufa12 3432 815
Ndufa13 1608 3366
Ndufa2 -1510 192
Ndufa3 1787 2433
Ndufa5 -1324 -2827
Ndufa6 -550 -726
Ndufa7 -2620 674
Ndufa8 -1960 -884
Ndufa9 -2828 -4058
Ndufab1 -4238 -5872
Ndufaf1 -7741 -7434
Ndufaf2 -5918 -5836
Ndufaf3 -1230 1625
Ndufaf4 -7519 -7833
Ndufaf5 -6087 -7047
Ndufaf6 356 -5560
Ndufaf7 1830 4138
Ndufb1 -1089 287
Ndufb10 -2926 -5205
Ndufb11 -4944 -4741
Ndufb2 -2452 -3682
Ndufb3 -4207 -3444
Ndufb4 -4223 -1829
Ndufb5 -5725 -6212
Ndufb6 -3325 -5439
Ndufb7 -637 523
Ndufb8 -3892 -3600
Ndufb9 -4209 -3192
Ndufc1 -2330 -3138
Ndufc2 -6855 -5673
Ndufs1 -5616 -5621
Ndufs2 -2561 -313
Ndufs3 -4327 -5091
Ndufs4 -6153 -5967
Ndufs5 -2819 -4381
Ndufs6 983 965
Ndufs7 1864 537
Ndufs8 -4519 -6311
Ndufv1 -1537 -1887
Ndufv2 -7249 -7621
Ndufv3 1171 525
Nubpl -7142 -4165
Timmdc1 -802 127
Tmem126b -3315 -2415
Tmem186 6860 6728



ACTIVATION OF SMO
ACTIVATION OF SMO
metric value
setSize 16
pMANOVA 0.0262
p.adjustMANOVA 0.0914
s.dist 0.513
s.LPS 0.358
s.OVA 0.368
p.LPS 0.0132
p.OVA 0.0109



Top 20 genes
Gene LPS OVA
Evc 8802 8900
Arrb1 8564 9090
Gas8 8159 8450
Iqce 8327 6433
Kif3a 8296 6017
Ptch1 7205 6040
Arrb2 7672 3691
Smo 3065 6979
Evc2 4866 3388
Cdon 1097 4341
Efcab7 819 272

Click HERE to show all gene set members

All member genes
LPS OVA
Arrb1 8564 9090
Arrb2 7672 3691
Boc -2215 -49
Cdon 1097 4341
Csnk1a1 -6831 -6407
Efcab7 819 272
Evc 8802 8900
Evc2 4866 3388
Gas1 -101 -76
Gas8 8159 8450
Grk2 -836 2567
Iqce 8327 6433
Kif3a 8296 6017
Ptch1 7205 6040
Shh -3436 -763
Smo 3065 6979



SYNAPTIC ADHESION LIKE MOLECULES
SYNAPTIC ADHESION LIKE MOLECULES
metric value
setSize 21
pMANOVA 0.00788
p.adjustMANOVA 0.0361
s.dist 0.504
s.LPS 0.389
s.OVA 0.321
p.LPS 0.00204
p.OVA 0.0109



Top 20 genes
Gene LPS OVA
Ptprf 8143 8675
Lrfn4 7209 8087
Grin2d 7884 7199
Dlg4 6137 8966
Grin2b 6674 7728
Ptprs 8427 5592
Lrfn3 5168 8318
Flot2 5545 7414
Grin1 7276 5563
Lrfn1 6803 4759
Lrfn2 3867 7766
Gria1 3573 5933
Flot1 2103 6655

Click HERE to show all gene set members

All member genes
LPS OVA
Dlg1 -6924 -5874
Dlg3 -137 5099
Dlg4 6137 8966
Flot1 2103 6655
Flot2 5545 7414
Gria1 3573 5933
Gria3 -3666 -7912
Gria4 711 -3298
Grin1 7276 5563
Grin2a 4886 -460
Grin2b 6674 7728
Grin2c 2536 -5736
Grin2d 7884 7199
Lrfn1 6803 4759
Lrfn2 3867 7766
Lrfn3 5168 8318
Lrfn4 7209 8087
Ptprd 5907 -603
Ptprf 8143 8675
Ptprs 8427 5592
Rtn3 -6364 -5066



RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
metric value
setSize 125
pMANOVA 1.42e-12
p.adjustMANOVA 2.39e-10
s.dist 0.504
s.LPS -0.353
s.OVA -0.359
p.LPS 9.66e-12
p.OVA 3.9e-12



Top 20 genes
Gene LPS OVA
Atp5c1 -8037 -7922
Ndufaf4 -7519 -7833
Atp5pb -7461 -7713
Ndufaf1 -7741 -7434
Dmac2l -7240 -7929
Ndufv2 -7249 -7621
Cycs -6807 -7995
Uqcrc2 -6972 -6909
Coq10b -7479 -6202
Ndufaf5 -6087 -7047
Etfa -6678 -6310
mt-Co2 -5502 -7647
Ndufc2 -6855 -5673
Uqcrfs1 -6258 -6207
Sdhb -6037 -6107
Ndufs4 -6153 -5967
mt-Nd6 -6506 -5628
Ndufb5 -5725 -6212
Etfdh -7099 -4873
Ndufaf2 -5918 -5836

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 -677 -2479
Atp5a1 -4471 -3464
Atp5b -4851 -5411
Atp5c1 -8037 -7922
Atp5d 317 -1642
Atp5e -1106 1068
Atp5g1 1338 397
Atp5g2 -3032 799
Atp5g3 -4427 -3685
Atp5h -4779 -5494
Atp5j -1090 -1384
Atp5j2 -1499 -2317
Atp5k 2028 2298
Atp5l -4651 -6088
Atp5o -4665 -6182
Atp5pb -7461 -7713
Coq10a -2671 -4038
Coq10b -7479 -6202
Cox11 -2194 -880
Cox14 -2675 -4179
Cox16 -3228 -7098
Cox18 -1085 1678
Cox19 1627 1226
Cox20 -1700 -992
Cox4i1 -2475 -2072
Cox5a -4257 -5813
Cox5b 1145 1275
Cox6a1 -2753 -2368
Cox6b1 -3830 -4351
Cox6c -1378 -973
Cox7a2l -4680 -2373
Cox7b -3290 -5544
Cox7c -2917 -2010
Cox8a -1252 2962
Cyc1 -4064 -4417
Cycs -6807 -7995
Dmac2l -7240 -7929
Ecsit -2855 -793
Etfa -6678 -6310
Etfb -4038 924
Etfdh -7099 -4873
Lrpprc 2465 -2248
mt-Atp6 -5036 -4677
mt-Atp8 7207 8276
mt-Co1 -5610 -2353
mt-Co2 -5502 -7647
mt-Co3 -5094 -5248
mt-Cytb -5465 -3497
mt-Nd1 -5959 -4811
mt-Nd2 -7019 -4749
mt-Nd3 254 4573
mt-Nd4 -6158 -3936
mt-Nd5 -5883 -1884
mt-Nd6 -6506 -5628
Ndufa1 -459 -969
Ndufa10 -4268 -6585
Ndufa11 -3102 -4612
Ndufa12 3432 815
Ndufa13 1608 3366
Ndufa2 -1510 192
Ndufa3 1787 2433
Ndufa4 -3806 -4267
Ndufa5 -1324 -2827
Ndufa6 -550 -726
Ndufa7 -2620 674
Ndufa8 -1960 -884
Ndufa9 -2828 -4058
Ndufab1 -4238 -5872
Ndufaf1 -7741 -7434
Ndufaf2 -5918 -5836
Ndufaf3 -1230 1625
Ndufaf4 -7519 -7833
Ndufaf5 -6087 -7047
Ndufaf6 356 -5560
Ndufaf7 1830 4138
Ndufb1 -1089 287
Ndufb10 -2926 -5205
Ndufb11 -4944 -4741
Ndufb2 -2452 -3682
Ndufb3 -4207 -3444
Ndufb4 -4223 -1829
Ndufb5 -5725 -6212
Ndufb6 -3325 -5439
Ndufb7 -637 523
Ndufb8 -3892 -3600
Ndufb9 -4209 -3192
Ndufc1 -2330 -3138
Ndufc2 -6855 -5673
Ndufs1 -5616 -5621
Ndufs2 -2561 -313
Ndufs3 -4327 -5091
Ndufs4 -6153 -5967
Ndufs5 -2819 -4381
Ndufs6 983 965
Ndufs7 1864 537
Ndufs8 -4519 -6311
Ndufv1 -1537 -1887
Ndufv2 -7249 -7621
Ndufv3 1171 525
Nubpl -7142 -4165
Pm20d1 5186 2497
Sco1 -5121 -6140
Sco2 -8317 -39
Sdha -732 1601
Sdhb -6037 -6107
Sdhc -5013 -1446
Sdhd -5538 -2713
Slc25a14 -1541 1011
Slc25a27 5944 1690
Surf1 -4284 -3081
Taco1 748 -2333
Timmdc1 -802 127
Tmem126b -3315 -2415
Tmem186 6860 6728
Trap1 4894 -871
Ucp2 6399 8739
Ucp3 -398 -4735
Uqcr10 650 1013
Uqcr11 -113 1026
Uqcrb -3706 -3673
Uqcrc1 -1846 -2145
Uqcrc2 -6972 -6909
Uqcrfs1 -6258 -6207
Uqcrh -4398 -3925
Uqcrq -1275 -45



GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
metric value
setSize 31
pMANOVA 0.00106
p.adjustMANOVA 0.00763
s.dist 0.5
s.LPS -0.376
s.OVA -0.329
p.LPS 0.000289
p.OVA 0.00151



Top 20 genes
Gene LPS OVA
Cdc42 -7981 -7659
Mtap -7870 -7536
Capza1 -7238 -6958
Tcp1 -7345 -6683
Hnrnpdl -6858 -6935
Rap1b -7562 -6217
Rala -5838 -5762
Taldo1 -6827 -4802
Ppia -5316 -5775
Arf1 -5497 -3810
Gsto1 -7775 -2471
Pitpna -2969 -5578
Cfl1 -3099 -5291
Lcp1 -2058 -7343
Hspa9 -3313 -2549
Psme2 -4090 -1734
Snrpa1 -2368 -2624
Hnrnpa2b1 -961 -5210
Aip -2276 -1869
Pdcd4 -2786 -1419

Click HERE to show all gene set members

All member genes
LPS OVA
Aip -2276 -1869
Anxa2 6789 5590
Arf1 -5497 -3810
Bola2 321 1062
Capza1 -7238 -6958
Cdc42 -7981 -7659
Cfl1 -3099 -5291
Cnn2 2168 2271
Gsto1 -7775 -2471
Hnrnpa2b1 -961 -5210
Hnrnpdl -6858 -6935
Hnrnpf -994 7229
Hspa9 -3313 -2549
Lcp1 -2058 -7343
Lmnb1 7 5698
Mif 1944 -790
Msn 4045 3615
Mtap -7870 -7536
Pak2 -4814 -23
Pdcd4 -2786 -1419
Pitpna -2969 -5578
Ppia -5316 -5775
Psme2 -4090 -1734
Rala -5838 -5762
Rap1b -7562 -6217
Rplp0 -3832 -225
Snrpa1 -2368 -2624
Sod1 390 1377
Sod2 1681 479
Taldo1 -6827 -4802
Tcp1 -7345 -6683



MITOCHONDRIAL PROTEIN IMPORT
MITOCHONDRIAL PROTEIN IMPORT
metric value
setSize 63
pMANOVA 1.37e-06
p.adjustMANOVA 3.26e-05
s.dist 0.498
s.LPS -0.347
s.OVA -0.357
p.LPS 1.86e-06
p.OVA 9.42e-07



Top 20 genes
Gene LPS OVA
Mtx2 -7995 -7767
Timm8a1 -7094 -7628
Tomm70a -7664 -6975
Pmpcb -7157 -6749
Timm23 -6977 -6679
Timm21 -6397 -7028
Slc25a4 -6616 -6552
Cmc4 -5597 -7602
Hspd1 -6227 -5853
Slc25a13 -7126 -5077
Chchd5 -5014 -6327
Tomm22 -6240 -4956
Grpel2 -6028 -4986
Atp5b -4851 -5411
Chchd3 -4604 -5339
Tomm20 -6634 -3660
Chchd2 -4459 -5081
Cmc2 -3287 -6323
Vdac1 -4598 -4107
Cyc1 -4064 -4417

Click HERE to show all gene set members

All member genes
LPS OVA
Aco2 78 -3935
Atp5a1 -4471 -3464
Atp5b -4851 -5411
Atp5g1 1338 397
Bcs1l 7058 3545
Chchd10 -1617 -1793
Chchd2 -4459 -5081
Chchd3 -4604 -5339
Chchd4 -3957 -2281
Chchd5 -5014 -6327
Chchd7 -2584 -5467
Cmc2 -3287 -6323
Cmc4 -5597 -7602
Coa4 -1133 919
Coa6 -4920 -389
Coq2 -3431 3938
Cox17 922 1165
Cox19 1627 1226
Cs -429 -687
Cyc1 -4064 -4417
Dnajc19 -1260 -2221
Fxn -2821 -4364
Gfer -2823 413
Grpel1 -4660 11
Grpel2 -6028 -4986
Hscb -4170 -401
Hspa9 -3313 -2549
Hspd1 -6227 -5853
Idh3g 805 -6073
Ldhd 3093 -2151
Mtx1 -5695 280
Mtx2 -7995 -7767
Ndufb8 -3892 -3600
Pam16 1310 908
Pitrm1 2057 -1875
Pmpca -2199 -1836
Pmpcb -7157 -6749
Samm50 893 145
Slc25a12 1764 1
Slc25a13 -7126 -5077
Slc25a4 -6616 -6552
Taz 4813 -2854
Timm10 -3881 -413
Timm10b -3129 -2306
Timm13 506 1366
Timm17a -1490 -1432
Timm17b -2946 1082
Timm21 -6397 -7028
Timm22 -2247 2569
Timm23 -6977 -6679
Timm44 -367 -5724
Timm50 -3310 -3327
Timm8a1 -7094 -7628
Timm8b -1904 -2154
Timm9 -2934 -4907
Tomm20 -6634 -3660
Tomm22 -6240 -4956
Tomm40 2437 5443
Tomm5 -2460 -1769
Tomm6 -1221 2798
Tomm7 -2499 -719
Tomm70a -7664 -6975
Vdac1 -4598 -4107



ASSEMBLY OF THE PRE REPLICATIVE COMPLEX
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX
metric value
setSize 65
pMANOVA 3.37e-07
p.adjustMANOVA 9.68e-06
s.dist 0.495
s.LPS -0.391
s.OVA -0.304
p.LPS 5.11e-08
p.OVA 2.19e-05



Top 20 genes
Gene LPS OVA
Psmc6 -8165 -8078
Orc5 -7767 -7983
Psmd12 -7839 -7875
Psmd14 -7926 -7512
Orc6 -7734 -7615
Orc4 -7333 -7976
Psma2 -7139 -7162
Psma1 -6516 -7402
Psma6 -7541 -6289
Psmd6 -7134 -5842
Psmd8 -6155 -6637
Psmd10 -5460 -6232
Psmb7 -5364 -6302
Mcm3 -7025 -4770
Psmb1 -5469 -5927
Psma5 -5762 -5258
Psma4 -4782 -6095
E2f2 -6938 -4122
Psmf1 -6994 -3729
Psmc2 -5029 -4436

Click HERE to show all gene set members

All member genes
LPS OVA
Cdt1 -1081 -2224
E2f1 3808 -285
E2f2 -6938 -4122
E2f3 -4080 -3624
Gmnn -580 -2256
Mcm2 -30 6277
Mcm3 -7025 -4770
Mcm4 -4046 -4194
Mcm5 -3588 3584
Mcm6 -1082 2565
Mcm7 439 3392
Mcm8 -2227 1086
Orc2 -5769 -3287
Orc3 -1278 -4858
Orc4 -7333 -7976
Orc5 -7767 -7983
Orc6 -7734 -7615
Psma1 -6516 -7402
Psma2 -7139 -7162
Psma3 -4486 -2446
Psma4 -4782 -6095
Psma5 -5762 -5258
Psma6 -7541 -6289
Psma7 -3949 -2500
Psma8 -3854 -5259
Psmb1 -5469 -5927
Psmb10 -2131 1135
Psmb2 -1616 317
Psmb3 -4559 -3061
Psmb4 -1462 2697
Psmb5 722 2001
Psmb6 -1639 -229
Psmb7 -5364 -6302
Psmb8 -6149 3828
Psmb9 -7823 184
Psmc1 -1670 -3103
Psmc2 -5029 -4436
Psmc3 -2320 -4845
Psmc4 120 298
Psmc5 -1534 -5726
Psmc6 -8165 -8078
Psmd1 1038 -270
Psmd10 -5460 -6232
Psmd11 -126 -1140
Psmd12 -7839 -7875
Psmd13 -2421 -2578
Psmd14 -7926 -7512
Psmd2 3304 1444
Psmd3 2880 3401
Psmd4 2223 2429
Psmd5 -4572 -3145
Psmd6 -7134 -5842
Psmd7 1441 3150
Psmd8 -6155 -6637
Psmd9 -3305 6885
Psme1 704 7692
Psme2 -4090 -1734
Psme3 -2346 -1578
Psme4 3539 -3562
Psmf1 -6994 -3729
Rps27a -4093 -1700
Sem1 -2404 -2338
Uba52 3635 5396
Ubb -4190 -2004
Ubc 3430 796



SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
metric value
setSize 87
pMANOVA 6.2e-09
p.adjustMANOVA 2.6e-07
s.dist 0.493
s.LPS -0.376
s.OVA -0.318
p.LPS 1.31e-09
p.OVA 2.85e-07



Top 20 genes
Gene LPS OVA
Psmc6 -8165 -8078
Ccne2 -8178 -8050
Ube2d1 -8182 -7638
Orc5 -7767 -7983
Psmd12 -7839 -7875
Ube2e1 -7934 -7580
Psmd14 -7926 -7512
Anapc10 -7409 -8014
Orc6 -7734 -7615
Orc4 -7333 -7976
Skp1 -7725 -7531
Cul1 -7412 -7233
Psma2 -7139 -7162
Psma1 -6516 -7402
Psma6 -7541 -6289
Psmd6 -7134 -5842
Psmd8 -6155 -6637
Cdc26 -6691 -5812
Cdc16 -6443 -5493
Psmd10 -5460 -6232

Click HERE to show all gene set members

All member genes
LPS OVA
Anapc1 5736 6021
Anapc10 -7409 -8014
Anapc11 -2232 2053
Anapc15 -2431 -3319
Anapc16 -4004 2438
Anapc2 7265 8062
Anapc4 -3070 -5642
Anapc5 5859 -538
Anapc7 -4488 1863
Ccna1 3397 543
Ccna2 5361 -4218
Ccne1 -3653 -3628
Ccne2 -8178 -8050
Cdc16 -6443 -5493
Cdc23 -3427 3030
Cdc26 -6691 -5812
Cdc27 -4996 -4310
Cdk2 6625 -3922
Cdt1 -1081 -2224
Cul1 -7412 -7233
Fzr1 -989 2318
Mcm2 -30 6277
Mcm3 -7025 -4770
Mcm4 -4046 -4194
Mcm5 -3588 3584
Mcm6 -1082 2565
Mcm7 439 3392
Mcm8 -2227 1086
Orc2 -5769 -3287
Orc3 -1278 -4858
Orc4 -7333 -7976
Orc5 -7767 -7983
Orc6 -7734 -7615
Psma1 -6516 -7402
Psma2 -7139 -7162
Psma3 -4486 -2446
Psma4 -4782 -6095
Psma5 -5762 -5258
Psma6 -7541 -6289
Psma7 -3949 -2500
Psma8 -3854 -5259
Psmb1 -5469 -5927
Psmb10 -2131 1135
Psmb2 -1616 317
Psmb3 -4559 -3061
Psmb4 -1462 2697
Psmb5 722 2001
Psmb6 -1639 -229
Psmb7 -5364 -6302
Psmb8 -6149 3828
Psmb9 -7823 184
Psmc1 -1670 -3103
Psmc2 -5029 -4436
Psmc3 -2320 -4845
Psmc4 120 298
Psmc5 -1534 -5726
Psmc6 -8165 -8078
Psmd1 1038 -270
Psmd10 -5460 -6232
Psmd11 -126 -1140
Psmd12 -7839 -7875
Psmd13 -2421 -2578
Psmd14 -7926 -7512
Psmd2 3304 1444
Psmd3 2880 3401
Psmd4 2223 2429
Psmd5 -4572 -3145
Psmd6 -7134 -5842
Psmd7 1441 3150
Psmd8 -6155 -6637
Psmd9 -3305 6885
Psme1 704 7692
Psme2 -4090 -1734
Psme3 -2346 -1578
Psme4 3539 -3562
Psmf1 -6994 -3729
Rbx1 -4694 -4715
Rps27a -4093 -1700
Sem1 -2404 -2338
Skp1 -7725 -7531
Skp2 -439 -1947
Uba52 3635 5396
Ubb -4190 -2004
Ubc 3430 796
Ube2d1 -8182 -7638
Ube2e1 -7934 -7580
Ube2s -4618 -3397



ORC1 REMOVAL FROM CHROMATIN
ORC1 REMOVAL FROM CHROMATIN
metric value
setSize 68
pMANOVA 4.77e-07
p.adjustMANOVA 1.25e-05
s.dist 0.493
s.LPS -0.37
s.OVA -0.326
p.LPS 1.33e-07
p.OVA 3.4e-06



Top 20 genes
Gene LPS OVA
Psmc6 -8165 -8078
Orc5 -7767 -7983
Psmd12 -7839 -7875
Psmd14 -7926 -7512
Orc6 -7734 -7615
Orc4 -7333 -7976
Skp1 -7725 -7531
Cul1 -7412 -7233
Psma2 -7139 -7162
Psma1 -6516 -7402
Psma6 -7541 -6289
Psmd6 -7134 -5842
Psmd8 -6155 -6637
Psmd10 -5460 -6232
Psmb7 -5364 -6302
Mcm3 -7025 -4770
Psmb1 -5469 -5927
Psma5 -5762 -5258
Psma4 -4782 -6095
Psmf1 -6994 -3729

Click HERE to show all gene set members

All member genes
LPS OVA
Ccna1 3397 543
Ccna2 5361 -4218
Cdk2 6625 -3922
Cdt1 -1081 -2224
Cul1 -7412 -7233
Mcm2 -30 6277
Mcm3 -7025 -4770
Mcm4 -4046 -4194
Mcm5 -3588 3584
Mcm6 -1082 2565
Mcm7 439 3392
Mcm8 -2227 1086
Orc2 -5769 -3287
Orc3 -1278 -4858
Orc4 -7333 -7976
Orc5 -7767 -7983
Orc6 -7734 -7615
Psma1 -6516 -7402
Psma2 -7139 -7162
Psma3 -4486 -2446
Psma4 -4782 -6095
Psma5 -5762 -5258
Psma6 -7541 -6289
Psma7 -3949 -2500
Psma8 -3854 -5259
Psmb1 -5469 -5927
Psmb10 -2131 1135
Psmb2 -1616 317
Psmb3 -4559 -3061
Psmb4 -1462 2697
Psmb5 722 2001
Psmb6 -1639 -229
Psmb7 -5364 -6302
Psmb8 -6149 3828
Psmb9 -7823 184
Psmc1 -1670 -3103
Psmc2 -5029 -4436
Psmc3 -2320 -4845
Psmc4 120 298
Psmc5 -1534 -5726
Psmc6 -8165 -8078
Psmd1 1038 -270
Psmd10 -5460 -6232
Psmd11 -126 -1140
Psmd12 -7839 -7875
Psmd13 -2421 -2578
Psmd14 -7926 -7512
Psmd2 3304 1444
Psmd3 2880 3401
Psmd4 2223 2429
Psmd5 -4572 -3145
Psmd6 -7134 -5842
Psmd7 1441 3150
Psmd8 -6155 -6637
Psmd9 -3305 6885
Psme1 704 7692
Psme2 -4090 -1734
Psme3 -2346 -1578
Psme4 3539 -3562
Psmf1 -6994 -3729
Rbx1 -4694 -4715
Rps27a -4093 -1700
Sem1 -2404 -2338
Skp1 -7725 -7531
Skp2 -439 -1947
Uba52 3635 5396
Ubb -4190 -2004
Ubc 3430 796



GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
metric value
setSize 12
pMANOVA 0.0511
p.adjustMANOVA 0.149
s.dist 0.491
s.LPS -0.405
s.OVA -0.278
p.LPS 0.015
p.OVA 0.0958



Top 20 genes
Gene LPS OVA
Rab2a -8285 -7770
Blzf1 -7246 -7380
Rab1a -7361 -6911
Cdk1 -6951 -4507
Uso1 -5293 -5378
Mapk1 -6064 -4483
Mapk3 -5105 -1667
Plk1 -330 -713
Gorasp2 -4149 -47

Click HERE to show all gene set members

All member genes
LPS OVA
Blzf1 -7246 -7380
Cdk1 -6951 -4507
Golga2 8581 8784
Gorasp1 6173 6340
Gorasp2 -4149 -47
Mapk1 -6064 -4483
Mapk3 -5105 -1667
Plk1 -330 -713
Rab1a -7361 -6911
Rab1b -2785 1180
Rab2a -8285 -7770
Uso1 -5293 -5378



METABOLISM OF POLYAMINES
METABOLISM OF POLYAMINES
metric value
setSize 58
pMANOVA 1.55e-06
p.adjustMANOVA 3.5e-05
s.dist 0.489
s.LPS -0.393
s.OVA -0.292
p.LPS 2.31e-07
p.OVA 0.000121



Top 20 genes
Gene LPS OVA
Psmc6 -8165 -8078
Psmd12 -7839 -7875
Psmd14 -7926 -7512
Sms -7723 -7507
Psma2 -7139 -7162
Psma1 -6516 -7402
Psma6 -7541 -6289
Azin1 -6538 -6828
Amd1 -7548 -5635
Psmd6 -7134 -5842
Psmd8 -6155 -6637
Psmd10 -5460 -6232
Psmb7 -5364 -6302
Psmb1 -5469 -5927
Psma5 -5762 -5258
Psma4 -4782 -6095
Sat1 -4094 -6485
Psmf1 -6994 -3729
Psmc2 -5029 -4436
Psma8 -3854 -5259

Click HERE to show all gene set members

All member genes
LPS OVA
Agmat 1847 -6194
Amd1 -7548 -5635
Azin1 -6538 -6828
Azin2 -397 5437
Nqo1 -7853 -1943
Oaz1 -1498 1634
Oaz2 -3924 5
Oaz3 6189 7863
Odc1 -4298 -158
Paox -5431 -439
Psma1 -6516 -7402
Psma2 -7139 -7162
Psma3 -4486 -2446
Psma4 -4782 -6095
Psma5 -5762 -5258
Psma6 -7541 -6289
Psma7 -3949 -2500
Psma8 -3854 -5259
Psmb1 -5469 -5927
Psmb10 -2131 1135
Psmb2 -1616 317
Psmb3 -4559 -3061
Psmb4 -1462 2697
Psmb5 722 2001
Psmb6 -1639 -229
Psmb7 -5364 -6302
Psmb8 -6149 3828
Psmb9 -7823 184
Psmc1 -1670 -3103
Psmc2 -5029 -4436
Psmc3 -2320 -4845
Psmc4 120 298
Psmc5 -1534 -5726
Psmc6 -8165 -8078
Psmd1 1038 -270
Psmd10 -5460 -6232
Psmd11 -126 -1140
Psmd12 -7839 -7875
Psmd13 -2421 -2578
Psmd14 -7926 -7512
Psmd2 3304 1444
Psmd3 2880 3401
Psmd4 2223 2429
Psmd5 -4572 -3145
Psmd6 -7134 -5842
Psmd7 1441 3150
Psmd8 -6155 -6637
Psmd9 -3305 6885
Psme1 704 7692
Psme2 -4090 -1734
Psme3 -2346 -1578
Psme4 3539 -3562
Psmf1 -6994 -3729
Sat1 -4094 -6485
Sem1 -2404 -2338
Smox 8657 9016
Sms -7723 -7507
Srm -4302 -1623



NEGATIVE REGULATION OF NOTCH4 SIGNALING
NEGATIVE REGULATION OF NOTCH4 SIGNALING
metric value
setSize 54
pMANOVA 3.97e-06
p.adjustMANOVA 8.5e-05
s.dist 0.488
s.LPS -0.392
s.OVA -0.291
p.LPS 6.14e-07
p.OVA 0.000217



Top 20 genes
Gene LPS OVA
Psmc6 -8165 -8078
Psmd12 -7839 -7875
Psmd14 -7926 -7512
Skp1 -7725 -7531
Cul1 -7412 -7233
Psma2 -7139 -7162
Psma1 -6516 -7402
Psma6 -7541 -6289
Psmd6 -7134 -5842
Psmd8 -6155 -6637
Psmd10 -5460 -6232
Psmb7 -5364 -6302
Psmb1 -5469 -5927
Fbxw7 -4310 -7130
Psma5 -5762 -5258
Psma4 -4782 -6095
Psmf1 -6994 -3729
Psmc2 -5029 -4436
Rbx1 -4694 -4715
Ywhaz -6934 -2917

Click HERE to show all gene set members

All member genes
LPS OVA
Akt1 437 3813
Cul1 -7412 -7233
Fbxw7 -4310 -7130
Notch4 8782 8588
Psma1 -6516 -7402
Psma2 -7139 -7162
Psma3 -4486 -2446
Psma4 -4782 -6095
Psma5 -5762 -5258
Psma6 -7541 -6289
Psma7 -3949 -2500
Psmb1 -5469 -5927
Psmb10 -2131 1135
Psmb2 -1616 317
Psmb3 -4559 -3061
Psmb4 -1462 2697
Psmb5 722 2001
Psmb6 -1639 -229
Psmb7 -5364 -6302
Psmb8 -6149 3828
Psmb9 -7823 184
Psmc1 -1670 -3103
Psmc2 -5029 -4436
Psmc3 -2320 -4845
Psmc4 120 298
Psmc5 -1534 -5726
Psmc6 -8165 -8078
Psmd1 1038 -270
Psmd10 -5460 -6232
Psmd11 -126 -1140
Psmd12 -7839 -7875
Psmd13 -2421 -2578
Psmd14 -7926 -7512
Psmd2 3304 1444
Psmd3 2880 3401
Psmd4 2223 2429
Psmd5 -4572 -3145
Psmd6 -7134 -5842
Psmd7 1441 3150
Psmd8 -6155 -6637
Psmd9 -3305 6885
Psme1 704 7692
Psme2 -4090 -1734
Psme3 -2346 -1578
Psmf1 -6994 -3729
Rbx1 -4694 -4715
Rps27a -4093 -1700
Sem1 -2404 -2338
Skp1 -7725 -7531
Tacc3 -1567 1301
Uba52 3635 5396
Ubb -4190 -2004
Ubc 3430 796
Ywhaz -6934 -2917



RECEPTOR MEDIATED MITOPHAGY
RECEPTOR MEDIATED MITOPHAGY
metric value
setSize 11
pMANOVA 0.0693
p.adjustMANOVA 0.181
s.dist 0.486
s.LPS -0.401
s.OVA -0.274
p.LPS 0.0212
p.OVA 0.116



Top 20 genes
Gene LPS OVA
Fundc1 -7970 -7901
Atg5 -7798 -7730
Atg12 -8166 -4952
Pgam5 -6770 -4375
Map1lc3b -4627 -5171
Csnk2a2 -5290 -2890
Map1lc3a -840 -697
Csnk2b -4315 -125

Click HERE to show all gene set members

All member genes
LPS OVA
Atg12 -8166 -4952
Atg5 -7798 -7730
Csnk2a1 -2158 1228
Csnk2a2 -5290 -2890
Csnk2b -4315 -125
Fundc1 -7970 -7901
Map1lc3a -840 -697
Map1lc3b -4627 -5171
Pgam5 -6770 -4375
Src 5356 7946
Ulk1 7403 4359



CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
metric value
setSize 47
pMANOVA 2.8e-05
p.adjustMANOVA 0.000477
s.dist 0.486
s.LPS -0.386
s.OVA -0.295
p.LPS 4.78e-06
p.OVA 0.000466



Top 20 genes
Gene LPS OVA
Psmc6 -8165 -8078
Psmd12 -7839 -7875
Psmd14 -7926 -7512
Psma2 -7139 -7162
Psma1 -6516 -7402
Psma6 -7541 -6289
Psmd6 -7134 -5842
Psmd8 -6155 -6637
Psmd10 -5460 -6232
Psmb7 -5364 -6302
Psmb1 -5469 -5927
Psma5 -5762 -5258
Psma4 -4782 -6095
Psmf1 -6994 -3729
Psmc2 -5029 -4436
Psma8 -3854 -5259
Psmd5 -4572 -3145
Psmb3 -4559 -3061
Psmc3 -2320 -4845
Psma3 -4486 -2446

Click HERE to show all gene set members

All member genes
LPS OVA
Fcgr1 -5346 16
Mrc1 -1864 -945
Mrc2 7291 8615
Psma1 -6516 -7402
Psma2 -7139 -7162
Psma3 -4486 -2446
Psma4 -4782 -6095
Psma5 -5762 -5258
Psma6 -7541 -6289
Psma7 -3949 -2500
Psma8 -3854 -5259
Psmb1 -5469 -5927
Psmb10 -2131 1135
Psmb2 -1616 317
Psmb3 -4559 -3061
Psmb4 -1462 2697
Psmb5 722 2001
Psmb6 -1639 -229
Psmb7 -5364 -6302
Psmb8 -6149 3828
Psmb9 -7823 184
Psmc1 -1670 -3103
Psmc2 -5029 -4436
Psmc3 -2320 -4845
Psmc4 120 298
Psmc5 -1534 -5726
Psmc6 -8165 -8078
Psmd1 1038 -270
Psmd10 -5460 -6232
Psmd11 -126 -1140
Psmd12 -7839 -7875
Psmd13 -2421 -2578
Psmd14 -7926 -7512
Psmd2 3304 1444
Psmd3 2880 3401
Psmd4 2223 2429
Psmd5 -4572 -3145
Psmd6 -7134 -5842
Psmd7 1441 3150
Psmd8 -6155 -6637
Psmd9 -3305 6885
Psme1 704 7692
Psme2 -4090 -1734
Psme3 -2346 -1578
Psme4 3539 -3562
Psmf1 -6994 -3729
Sem1 -2404 -2338



RETINOID CYCLE DISEASE EVENTS
RETINOID CYCLE DISEASE EVENTS
metric value
setSize 10
pMANOVA 0.000456
p.adjustMANOVA 0.004
s.dist 0.485
s.LPS -0.485
s.OVA 0.00194
p.LPS 0.00796
p.OVA 0.992



Top 20 genes
Gene LPS OVA
Rbp1 -3586 5251
Stra6 -8186 697

Click HERE to show all gene set members

All member genes
LPS OVA
Abca4 -8124 -2144
Lrat 781 -554
Napepld -5178 -1148
Rbp1 -3586 5251
Rbp4 2207 3995
Rdh12 -4986 -3965
Rdh5 -6198 -1311
Rlbp1 1473 7424
Stra6 -8186 697
Ttr -7370 -2948



APOPTOSIS INDUCED DNA FRAGMENTATION
APOPTOSIS INDUCED DNA FRAGMENTATION
metric value
setSize 10
pMANOVA 0.11
p.adjustMANOVA 0.244
s.dist 0.484
s.LPS -0.295
s.OVA -0.383
p.LPS 0.106
p.OVA 0.0358



Top 20 genes
Gene LPS OVA
H1f0 -7840 -7529
Kpna1 -6864 -6639
Hmgb1 -6598 -5641
H1f2 -7904 -3876
Hmgb2 -8095 -3774

Click HERE to show all gene set members

All member genes
LPS OVA
Casp3 1556 -1247
Dffa 4525 -3374
Dffb 4070 -3549
H1f0 -7840 -7529
H1f2 -7904 -3876
H1f4 1403 3420
Hmgb1 -6598 -5641
Hmgb2 -8095 -3774
Kpna1 -6864 -6639
Kpnb1 2911 4313



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report