Mitch Report

date generated: 2023-08-30

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
0610005C13Rik	1.7086294
0610009B22Rik	-2.3583781
0610009E02Rik	-0.4921631
0610009L18Rik	-1.5061599
0610010K14Rik	-0.7608005
0610012G03Rik	-0.6314820

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	1604
num_genes_in_profile	17472
duplicated_genes_present	0
num_profile_genes_in_sets	8440
num_profile_genes_not_in_sets	9032

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene set metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	425
num_genesets_included	1179

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pANOVA	s.dist	p.adjustANOVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	1.41e-04	-0.695	1.54e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.95e-04	0.680	2.03e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	6.32e-05	0.560	8.09e-04
ENDOSOMAL VACUOLAR PATHWAY	10	3.88e-03	-0.527	2.56e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.83e-03	-0.520	1.97e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	4.35e-06	0.511	8.55e-05
RETINOID CYCLE DISEASE EVENTS	10	7.39e-03	-0.489	4.22e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	6.40e-06	-0.484	1.13e-04
LGI ADAM INTERACTIONS	14	2.77e-03	0.462	1.95e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	9.97e-03	0.449	5.37e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.16e-04	-0.448	4.82e-03
P75NTR REGULATES AXONOGENESIS	10	1.52e-02	-0.443	7.35e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	15	3.18e-03	-0.440	2.14e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	1.16e-02	0.440	6.05e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	1.13e-03	0.421	9.22e-03
CD28 DEPENDENT VAV1 PATHWAY	11	1.75e-02	-0.414	8.17e-02
RORA ACTIVATES GENE EXPRESSION	18	2.58e-03	0.410	1.86e-02
MITOCHONDRIAL TRANSLATION	93	1.33e-11	-0.406	2.61e-09
RECEPTOR MEDIATED MITOPHAGY	11	2.00e-02	-0.405	8.88e-02
CRISTAE FORMATION	31	1.04e-04	-0.403	1.23e-03
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.53e-03	-0.399	1.20e-02
PENTOSE PHOSPHATE PATHWAY	13	1.30e-02	-0.398	6.52e-02
METABOLISM OF POLYAMINES	58	1.59e-07	-0.398	6.05e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	4.46e-04	-0.398	4.28e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	4.32e-07	-0.398	1.34e-05
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	2.78e-03	-0.396	1.95e-02
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	3.29e-08	-0.396	1.69e-06
SIGNALING BY LEPTIN	10	3.01e-02	0.396	1.18e-01
TIGHT JUNCTION INTERACTIONS	17	4.74e-03	-0.396	3.04e-02
UNWINDING OF DNA	12	1.86e-02	-0.392	8.47e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.49e-06	-0.391	7.49e-05
RESPIRATORY ELECTRON TRANSPORT	102	1.02e-11	-0.390	2.41e-09
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	1.49e-02	-0.390	7.25e-02
PHOSPHORYLATION OF THE APC C	18	4.69e-03	-0.385	3.03e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	2.90e-03	-0.385	2.01e-02
SYNAPTIC ADHESION LIKE MOLECULES	21	2.31e-03	0.384	1.70e-02
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	2.37e-04	-0.381	2.45e-03
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	7.74e-10	-0.381	5.71e-08
METHYLATION	11	2.99e-02	-0.378	1.17e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.83e-02	0.378	8.47e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	9.17e-04	0.376	7.66e-03
ORC1 REMOVAL FROM CHROMATIN	68	8.69e-08	-0.375	3.63e-06
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	3.73e-03	-0.375	2.47e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	2.50e-02	-0.374	1.04e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	7.83e-07	-0.372	2.20e-05
PROTEIN UBIQUITINATION	70	7.66e-08	-0.372	3.34e-06
PROCESSING AND ACTIVATION OF SUMO	10	4.22e-02	-0.371	1.47e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	6.98e-03	-0.367	4.03e-02
COMPLEX I BIOGENESIS	56	2.06e-06	-0.367	4.67e-05
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	9.26e-08	-0.367	3.64e-06

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	1.41e-04	-0.695000	1.54e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.95e-04	0.680000	2.03e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	6.32e-05	0.560000	8.09e-04
ENDOSOMAL VACUOLAR PATHWAY	10	3.88e-03	-0.527000	2.56e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.83e-03	-0.520000	1.97e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	4.35e-06	0.511000	8.55e-05
RETINOID CYCLE DISEASE EVENTS	10	7.39e-03	-0.489000	4.22e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	6.40e-06	-0.484000	1.13e-04
LGI ADAM INTERACTIONS	14	2.77e-03	0.462000	1.95e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	9.97e-03	0.449000	5.37e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.16e-04	-0.448000	4.82e-03
P75NTR REGULATES AXONOGENESIS	10	1.52e-02	-0.443000	7.35e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	15	3.18e-03	-0.440000	2.14e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	1.16e-02	0.440000	6.05e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	1.13e-03	0.421000	9.22e-03
CD28 DEPENDENT VAV1 PATHWAY	11	1.75e-02	-0.414000	8.17e-02
RORA ACTIVATES GENE EXPRESSION	18	2.58e-03	0.410000	1.86e-02
MITOCHONDRIAL TRANSLATION	93	1.33e-11	-0.406000	2.61e-09
RECEPTOR MEDIATED MITOPHAGY	11	2.00e-02	-0.405000	8.88e-02
CRISTAE FORMATION	31	1.04e-04	-0.403000	1.23e-03
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.53e-03	-0.399000	1.20e-02
PENTOSE PHOSPHATE PATHWAY	13	1.30e-02	-0.398000	6.52e-02
METABOLISM OF POLYAMINES	58	1.59e-07	-0.398000	6.05e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	4.46e-04	-0.398000	4.28e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	4.32e-07	-0.398000	1.34e-05
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	2.78e-03	-0.396000	1.95e-02
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	3.29e-08	-0.396000	1.69e-06
SIGNALING BY LEPTIN	10	3.01e-02	0.396000	1.18e-01
TIGHT JUNCTION INTERACTIONS	17	4.74e-03	-0.396000	3.04e-02
UNWINDING OF DNA	12	1.86e-02	-0.392000	8.47e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.49e-06	-0.391000	7.49e-05
RESPIRATORY ELECTRON TRANSPORT	102	1.02e-11	-0.390000	2.41e-09
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	1.49e-02	-0.390000	7.25e-02
PHOSPHORYLATION OF THE APC C	18	4.69e-03	-0.385000	3.03e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	2.90e-03	-0.385000	2.01e-02
SYNAPTIC ADHESION LIKE MOLECULES	21	2.31e-03	0.384000	1.70e-02
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	2.37e-04	-0.381000	2.45e-03
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	7.74e-10	-0.381000	5.71e-08
METHYLATION	11	2.99e-02	-0.378000	1.17e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.83e-02	0.378000	8.47e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	9.17e-04	0.376000	7.66e-03
ORC1 REMOVAL FROM CHROMATIN	68	8.69e-08	-0.375000	3.63e-06
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	3.73e-03	-0.375000	2.47e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	2.50e-02	-0.374000	1.04e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	7.83e-07	-0.372000	2.20e-05
PROTEIN UBIQUITINATION	70	7.66e-08	-0.372000	3.34e-06
PROCESSING AND ACTIVATION OF SUMO	10	4.22e-02	-0.371000	1.47e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	6.98e-03	-0.367000	4.03e-02
COMPLEX I BIOGENESIS	56	2.06e-06	-0.367000	4.67e-05
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	9.26e-08	-0.367000	3.64e-06
RHOBTB3 ATPASE CYCLE	10	4.50e-02	-0.366000	1.54e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	1.68e-03	0.363000	1.29e-02
RAB GERANYLGERANYLATION	58	1.84e-06	-0.362000	4.25e-05
E2F MEDIATED REGULATION OF DNA REPLICATION	20	5.09e-03	-0.362000	3.19e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	11	3.78e-02	-0.362000	1.36e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	7.55e-04	-0.361000	6.74e-03
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	6.13e-04	-0.361000	5.60e-03
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	4.56e-06	-0.361000	8.81e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	6.59e-03	-0.360000	3.87e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	64	6.91e-07	-0.359000	1.99e-05
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	4.38e-12	-0.359000	1.29e-09
GLUTATHIONE CONJUGATION	29	8.68e-04	-0.357000	7.42e-03
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.08e-03	0.357000	8.93e-03
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	7.57e-03	-0.354000	4.27e-02
ACTIVATION OF SMO	16	1.44e-02	0.353000	7.10e-02
MITOCHONDRIAL PROTEIN IMPORT	63	1.23e-06	-0.353000	3.38e-05
DNA REPLICATION PRE INITIATION	80	5.29e-08	-0.352000	2.49e-06
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	15	1.83e-02	-0.352000	8.47e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	2.98e-06	-0.352000	6.56e-05
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	51	1.45e-05	-0.351000	2.19e-04
TRIGLYCERIDE CATABOLISM	14	2.38e-02	-0.349000	1.01e-01
INTERLEUKIN 6 SIGNALING	10	5.63e-02	0.349000	1.78e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	83	4.26e-08	-0.348000	2.09e-06
INTERLEUKIN 12 SIGNALING	36	3.04e-04	-0.348000	3.04e-03
S PHASE	154	1.33e-13	-0.346000	7.76e-11
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	60	3.93e-06	-0.344000	8.13e-05
PROTEIN METHYLATION	17	1.42e-02	-0.344000	7.01e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	2.42e-03	-0.344000	1.78e-02
DNA REPLICATION	122	5.78e-11	-0.343000	7.23e-09
HIV TRANSCRIPTION INITIATION	45	6.91e-05	-0.343000	8.49e-04
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	13	3.38e-02	-0.340000	1.25e-01
DEGRADATION OF DVL	56	1.09e-05	-0.340000	1.72e-04
INSULIN RECEPTOR RECYCLING	20	8.66e-03	-0.339000	4.72e-02
PHASE 4 RESTING MEMBRANE POTENTIAL	14	2.85e-02	-0.338000	1.14e-01
CRMPS IN SEMA3A SIGNALING	16	1.95e-02	0.337000	8.68e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	69	1.48e-06	-0.335000	3.72e-05
MET ACTIVATES RAP1 AND RAC1	10	6.65e-02	-0.335000	1.97e-01
DEGRADATION OF AXIN	54	2.11e-05	-0.335000	3.10e-04
G BETA GAMMA SIGNALLING THROUGH CDC42	19	1.20e-02	-0.333000	6.18e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	2.89e-05	-0.332000	4.11e-04
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	60	8.98e-06	-0.331000	1.47e-04
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	3.87e-02	0.331000	1.38e-01
PYRUVATE METABOLISM	27	2.95e-03	-0.331000	2.02e-02
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	1.32e-03	0.328000	1.06e-02
MATURATION OF NUCLEOPROTEIN	10	7.48e-02	-0.325000	2.16e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	5.20e-04	0.325000	4.82e-03
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.97e-13	-0.325000	7.76e-11
DEGRADATION OF GLI1 BY THE PROTEASOME	58	1.99e-05	-0.324000	2.97e-04
RAS PROCESSING	24	6.10e-03	-0.323000	3.63e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	6.33e-02	-0.323000	1.91e-01
NGF STIMULATED TRANSCRIPTION	36	8.24e-04	-0.322000	7.14e-03
PERK REGULATES GENE EXPRESSION	28	3.24e-03	-0.321000	2.17e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	3.67e-07	-0.321000	1.24e-05
EARLY PHASE OF HIV LIFE CYCLE	13	4.51e-02	-0.321000	1.54e-01
STABILIZATION OF P53	55	4.02e-05	-0.320000	5.51e-04
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.37e-02	-0.319000	6.82e-02
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	3.27e-02	-0.319000	1.23e-01
PHASE II CONJUGATION OF COMPOUNDS	63	1.32e-05	-0.317000	2.03e-04
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	5.70e-02	-0.317000	1.78e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	3.99e-02	0.317000	1.42e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	53	6.64e-05	0.317000	8.33e-04
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	14	4.11e-02	-0.315000	1.44e-01
PROCESSING OF SMDT1	16	2.91e-02	-0.315000	1.15e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	8.64e-02	0.313000	2.38e-01
DNA STRAND ELONGATION	32	2.23e-03	-0.312000	1.66e-02
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	27	4.99e-03	0.312000	3.15e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	24	8.21e-03	-0.312000	4.54e-02
RUNX3 REGULATES NOTCH SIGNALING	13	5.19e-02	0.311000	1.68e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	36	1.28e-03	0.310000	1.04e-02
CELLULAR RESPONSE TO HYPOXIA	73	4.65e-06	-0.310000	8.84e-05
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	69	8.48e-06	-0.310000	1.43e-04
REGULATION OF BACH1 ACTIVITY	11	7.58e-02	-0.309000	2.18e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	3.23e-02	0.309000	1.22e-01
EUKARYOTIC TRANSLATION INITIATION	115	1.08e-08	-0.309000	6.39e-07
INTERFERON ALPHA BETA SIGNALING	56	6.86e-05	-0.308000	8.49e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	2.24e-03	-0.307000	1.66e-02
MITOTIC G1 PHASE AND G1 S TRANSITION	141	3.46e-10	-0.306000	2.92e-08
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	4.42e-03	-0.305000	2.89e-02
MET ACTIVATES PTK2 SIGNALING	28	5.23e-03	0.305000	3.21e-02
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	1.00e-02	-0.304000	5.37e-02
TRANSLATION	287	1.10e-18	-0.303000	1.30e-15
PROTEIN LOCALIZATION	157	6.13e-11	-0.303000	7.23e-09
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	17	3.09e-02	-0.302000	1.20e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	3.10e-02	0.302000	1.20e-01
ACTIVATION OF RAC1	13	6.03e-02	-0.301000	1.84e-01
DARPP 32 EVENTS	23	1.27e-02	-0.300000	6.46e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	4.15e-06	-0.300000	8.44e-05
APOPTOSIS INDUCED DNA FRAGMENTATION	10	1.01e-01	-0.300000	2.57e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.30e-02	-0.299000	6.52e-02
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	107	8.93e-08	-0.299000	3.63e-06
BUDDING AND MATURATION OF HIV VIRION	27	7.41e-03	-0.298000	4.22e-02
REGULATION OF PTEN STABILITY AND ACTIVITY	68	2.21e-05	-0.298000	3.22e-04
INTERLEUKIN 37 SIGNALING	18	2.95e-02	0.296000	1.16e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	5.87e-03	-0.296000	3.55e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	6.54e-02	-0.295000	1.95e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	22	1.68e-02	-0.295000	7.93e-02
OTHER SEMAPHORIN INTERACTIONS	19	2.66e-02	0.294000	1.08e-01
KINESINS	47	5.02e-04	0.293000	4.74e-03
INTERLEUKIN 12 FAMILY SIGNALING	43	8.96e-04	-0.293000	7.58e-03
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	2.72e-02	-0.293000	1.10e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	14	5.82e-02	-0.292000	1.80e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	1.27e-04	-0.291000	1.41e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	2.92e-03	-0.291000	2.02e-02
FCERI MEDIATED NF KB ACTIVATION	77	1.05e-05	-0.290000	1.68e-04
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	8.30e-02	-0.289000	2.32e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	85	4.34e-06	-0.288000	8.55e-05
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	24	1.46e-02	-0.288000	7.13e-02
PHASE 2 PLATEAU PHASE	12	8.41e-02	0.288000	2.35e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	4.74e-02	-0.286000	1.58e-01
PYROPTOSIS	21	2.34e-02	-0.286000	1.00e-01
RNA POLYMERASE III CHAIN ELONGATION	18	3.63e-02	-0.285000	1.31e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	96	1.46e-06	-0.285000	3.72e-05
PURINE CATABOLISM	16	4.89e-02	-0.284000	1.61e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	5.70e-02	0.284000	1.78e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	7.90e-06	-0.284000	1.35e-04
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	1.61e-02	-0.284000	7.73e-02
SULFUR AMINO ACID METABOLISM	23	1.87e-02	-0.283000	8.49e-02
TERMINATION OF TRANSLESION DNA SYNTHESIS	31	6.57e-03	-0.282000	3.87e-02
ANTIGEN PROCESSING CROSS PRESENTATION	99	1.27e-06	-0.282000	3.41e-05
RRNA PROCESSING IN THE MITOCHONDRION	10	1.23e-01	-0.281000	2.95e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	3.38e-02	-0.281000	1.25e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	6.86e-02	0.281000	2.01e-01
METABOLISM OF COFACTORS	19	3.41e-02	-0.281000	1.25e-01
SIGNALING BY FGFR2 IIIA TM	19	3.58e-02	-0.278000	1.30e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	7.36e-03	-0.278000	4.22e-02
FORMATION OF APOPTOSOME	10	1.28e-01	-0.278000	3.00e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	17	4.81e-02	-0.277000	1.60e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	4.95e-04	-0.277000	4.70e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	9.05e-03	0.275000	4.92e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	6.48e-02	-0.275000	1.94e-01
HEDGEHOG LIGAND BIOGENESIS	62	1.78e-04	-0.275000	1.91e-03
TRANSLESION SYNTHESIS BY POLK	17	5.02e-02	-0.274000	1.64e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	13	8.69e-02	0.274000	2.39e-01
EUKARYOTIC TRANSLATION ELONGATION	88	8.99e-06	-0.274000	1.47e-04
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.01e-01	-0.273000	2.57e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	6.92e-03	-0.272000	4.03e-02
G1 S DNA DAMAGE CHECKPOINTS	66	1.37e-04	-0.272000	1.51e-03
POLYMERASE SWITCHING	14	7.89e-02	-0.271000	2.22e-01
TRANSLESION SYNTHESIS BY POLH	19	4.12e-02	-0.271000	1.44e-01
MRNA CAPPING	29	1.22e-02	-0.269000	6.24e-02
REGULATION OF RAS BY GAPS	67	1.43e-04	-0.269000	1.55e-03
HS GAG DEGRADATION	21	3.35e-02	0.268000	1.25e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	1.45e-01	-0.266000	3.24e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	1.26e-01	-0.266000	2.98e-01
NEUREXINS AND NEUROLIGINS	54	7.62e-04	0.265000	6.76e-03
FORMATION OF INCISION COMPLEX IN GG NER	43	2.67e-03	-0.265000	1.90e-02
IRON UPTAKE AND TRANSPORT	52	9.76e-04	-0.264000	8.11e-03
LAGGING STRAND SYNTHESIS	20	4.12e-02	-0.264000	1.44e-01
HYALURONAN METABOLISM	16	6.80e-02	0.264000	2.00e-01
INTERLEUKIN 7 SIGNALING	19	4.68e-02	0.263000	1.57e-01
CLEC7A DECTIN 1 SIGNALING	95	9.54e-06	-0.263000	1.54e-04
GLUTATHIONE SYNTHESIS AND RECYCLING	11	1.31e-01	-0.263000	3.05e-01
DNA DAMAGE BYPASS	47	1.87e-03	-0.262000	1.42e-02
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	7.17e-02	-0.260000	2.09e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	27	1.95e-02	-0.260000	8.68e-02
NRAGE SIGNALS DEATH THROUGH JNK	55	9.00e-04	0.259000	7.58e-03
GP1B IX V ACTIVATION SIGNALLING	11	1.38e-01	0.259000	3.16e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	4.57e-02	0.258000	1.54e-01
RHOC GTPASE CYCLE	74	1.25e-04	0.258000	1.41e-03
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	3.23e-02	-0.258000	1.22e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	4.67e-02	0.257000	1.57e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	7.79e-03	-0.256000	4.38e-02
INTERLEUKIN 15 SIGNALING	12	1.25e-01	0.256000	2.96e-01
MITOPHAGY	29	1.71e-02	-0.256000	8.05e-02
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	2.70e-02	-0.256000	1.09e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	85	4.68e-05	-0.256000	6.28e-04
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	1.61e-03	-0.255000	1.24e-02
RHOB GTPASE CYCLE	68	2.79e-04	0.255000	2.86e-03
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	3.46e-02	-0.255000	1.27e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	7.87e-02	-0.254000	2.22e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.28e-01	-0.254000	3.00e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	3.95e-02	-0.254000	1.41e-01
HEME BIOSYNTHESIS	13	1.14e-01	-0.253000	2.79e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS	165	2.24e-08	-0.252000	1.20e-06
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	5.07e-02	0.252000	1.65e-01
SELENOAMINO ACID METABOLISM	110	5.04e-06	-0.252000	9.06e-05
REGULATED NECROSIS	46	3.12e-03	-0.252000	2.11e-02
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	34	1.11e-02	-0.252000	5.84e-02
G2 M CHECKPOINTS	136	4.10e-07	-0.252000	1.31e-05
METABOLISM OF PORPHYRINS	19	5.81e-02	-0.251000	1.80e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	15	9.25e-02	0.251000	2.46e-01
RNA POLYMERASE I PROMOTER ESCAPE	48	2.65e-03	-0.251000	1.89e-02
DERMATAN SULFATE BIOSYNTHESIS	11	1.50e-01	0.250000	3.34e-01
CS DS DEGRADATION	14	1.06e-01	0.250000	2.65e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	7.63e-05	0.248000	9.27e-04
HOST INTERACTIONS OF HIV FACTORS	126	1.54e-06	-0.248000	3.78e-05
ENOS ACTIVATION	11	1.54e-01	-0.248000	3.39e-01
CELLULAR RESPONSE TO STARVATION	147	2.30e-07	-0.247000	8.22e-06
TELOMERE C STRAND SYNTHESIS INITIATION	13	1.23e-01	-0.247000	2.94e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	1.10e-04	-0.246000	1.28e-03
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	1.47e-02	-0.245000	7.19e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	1.00e-01	-0.245000	2.57e-01
VOLTAGE GATED POTASSIUM CHANNELS	39	8.06e-03	0.245000	4.50e-02
ERKS ARE INACTIVATED	13	1.26e-01	-0.245000	2.97e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	1.01e-01	0.245000	2.57e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	1.80e-01	-0.245000	3.76e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	7.99e-04	-0.244000	7.00e-03
ANCHORING FIBRIL FORMATION	14	1.16e-01	0.243000	2.81e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	1.04e-01	-0.243000	2.62e-01
DUAL INCISION IN TC NER	64	8.02e-04	-0.242000	7.00e-03
C TYPE LECTIN RECEPTORS CLRS	116	6.82e-06	-0.242000	1.18e-04
CITRIC ACID CYCLE TCA CYCLE	22	4.96e-02	-0.242000	1.63e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	4.04e-02	-0.242000	1.43e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	5.16e-03	-0.241000	3.20e-02
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	6.31e-02	0.240000	1.91e-01
TNFR2 NON CANONICAL NF KB PATHWAY	82	1.80e-04	-0.239000	1.92e-03
CONDENSATION OF PROPHASE CHROMOSOMES	29	2.60e-02	-0.239000	1.07e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	2.98e-04	-0.238000	3.01e-03
SIGNALING BY NTRK3 TRKC	17	8.94e-02	0.238000	2.42e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	1.41e-01	-0.236000	3.20e-01
PEROXISOMAL PROTEIN IMPORT	58	1.92e-03	-0.236000	1.45e-02
INHIBITION OF DNA RECOMBINATION AT TELOMERE	36	1.45e-02	-0.236000	7.11e-02
PHASE 0 RAPID DEPOLARISATION	28	3.22e-02	0.234000	1.22e-01
BILE ACID AND BILE SALT METABOLISM	25	4.31e-02	0.234000	1.49e-01
SUPPRESSION OF PHAGOSOMAL MATURATION	12	1.62e-01	-0.233000	3.51e-01
SIGNALING BY THE B CELL RECEPTOR BCR	104	4.22e-05	-0.232000	5.72e-04
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	2.03e-01	-0.232000	4.07e-01
CDC42 GTPASE CYCLE	154	6.78e-07	0.232000	1.99e-05
FGFR1 LIGAND BINDING AND ACTIVATION	10	2.05e-01	-0.232000	4.07e-01
HIV INFECTION	222	2.88e-09	-0.231000	2.00e-07
SEPARATION OF SISTER CHROMATIDS	166	2.71e-07	-0.231000	9.40e-06
ECM PROTEOGLYCANS	66	1.17e-03	0.231000	9.48e-03
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	8.97e-02	-0.231000	2.43e-01
FERTILIZATION	13	1.50e-01	0.231000	3.34e-01
THE NLRP3 INFLAMMASOME	14	1.36e-01	-0.230000	3.14e-01
TRIGLYCERIDE METABOLISM	24	5.21e-02	-0.229000	1.68e-01
INTERFERON GAMMA SIGNALING	79	4.36e-04	-0.229000	4.21e-03
SIGNALING BY NOTCH4	83	3.47e-04	-0.227000	3.41e-03
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	6.00e-02	-0.227000	1.84e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	38	1.57e-02	-0.227000	7.54e-02
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	9.65e-02	0.226000	2.51e-01
MAPK6 MAPK4 SIGNALING	85	3.14e-04	-0.226000	3.11e-03
CELLULAR RESPONSE TO CHEMICAL STRESS	152	1.77e-06	-0.225000	4.18e-05
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	2.20e-01	0.224000	4.25e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	21	7.62e-02	-0.224000	2.19e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	5.37e-02	-0.223000	1.71e-01
SIGNALING BY FGFR2 IN DISEASE	37	1.92e-02	-0.222000	8.63e-02
METALLOPROTEASE DUBS	25	5.44e-02	-0.222000	1.73e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	6.61e-02	0.221000	1.96e-01
CYTOPROTECTION BY HMOX1	119	3.13e-05	-0.221000	4.39e-04
NONSENSE MEDIATED DECAY NMD	110	6.31e-05	-0.221000	8.09e-04
MISMATCH REPAIR	14	1.53e-01	-0.221000	3.36e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	26	5.16e-02	-0.221000	1.67e-01
INFLUENZA INFECTION	146	4.88e-06	-0.219000	9.06e-05
MITOTIC METAPHASE AND ANAPHASE	208	5.59e-08	-0.219000	2.53e-06
DISEASES OF MITOTIC CELL CYCLE	37	2.15e-02	-0.218000	9.36e-02
ASPARTATE AND ASPARAGINE METABOLISM	11	2.10e-01	-0.218000	4.11e-01
NICOTINAMIDE SALVAGING	15	1.44e-01	-0.218000	3.24e-01
CHOLESTEROL BIOSYNTHESIS	24	6.59e-02	-0.217000	1.96e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	2.35e-01	0.217000	4.44e-01
NCAM1 INTERACTIONS	41	1.63e-02	0.217000	7.76e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES	320	2.92e-11	-0.217000	4.92e-09
NUCLEOTIDE EXCISION REPAIR	109	1.02e-04	-0.216000	1.21e-03
OLFACTORY SIGNALING PATHWAY	33	3.28e-02	0.215000	1.23e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	14	1.67e-01	-0.214000	3.59e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	25	6.46e-02	-0.214000	1.94e-01
ION TRANSPORT BY P TYPE ATPASES	51	8.42e-03	0.213000	4.64e-02
EFFECTS OF PIP2 HYDROLYSIS	27	5.55e-02	0.213000	1.76e-01
NEPHRIN FAMILY INTERACTIONS	23	7.72e-02	0.213000	2.20e-01
GLYCOGEN SYNTHESIS	14	1.70e-01	-0.212000	3.61e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	8.54e-02	0.212000	2.37e-01
CELL CYCLE CHECKPOINTS	244	1.32e-08	-0.211000	7.41e-07
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	1.45e-03	-0.211000	1.15e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	2.05e-01	-0.211000	4.07e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	1.88e-01	-0.211000	3.85e-01
ERK MAPK TARGETS	22	8.71e-02	-0.211000	2.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	1.74e-01	0.210000	3.67e-01
FC EPSILON RECEPTOR FCERI SIGNALING	124	5.57e-05	-0.210000	7.30e-04
PKA MEDIATED PHOSPHORYLATION OF CREB	19	1.14e-01	0.210000	2.79e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	1.75e-02	0.209000	8.17e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	2.20e-02	-0.209000	9.45e-02
PRE NOTCH PROCESSING IN GOLGI	18	1.25e-01	0.209000	2.96e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	9.02e-02	-0.209000	2.43e-01
G PROTEIN BETA GAMMA SIGNALLING	31	4.49e-02	-0.208000	1.54e-01
RRNA PROCESSING	195	5.69e-07	-0.208000	1.72e-05
TCR SIGNALING	102	2.96e-04	-0.207000	3.01e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA	14	1.82e-01	-0.206000	3.77e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	1.30e-01	-0.206000	3.03e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	2.61e-02	0.206000	1.07e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	1.43e-01	-0.205000	3.22e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	5.26e-03	-0.205000	3.21e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	2.62e-01	-0.205000	4.75e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	9.80e-02	0.204000	2.54e-01
SHC MEDIATED CASCADE FGFR1	16	1.58e-01	-0.204000	3.46e-01
G0 AND EARLY G1	25	7.80e-02	-0.204000	2.21e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	18	1.38e-01	-0.202000	3.16e-01
DUAL INCISION IN GG NER	40	2.74e-02	-0.202000	1.10e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	4.88e-02	0.201000	1.61e-01
COPII MEDIATED VESICLE TRANSPORT	66	4.83e-03	-0.201000	3.08e-02
SARS COV 1 INFECTION	48	1.68e-02	-0.199000	7.93e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	2.54e-01	0.199000	4.66e-01
INTERLEUKIN 1 SIGNALING	96	8.60e-04	-0.197000	7.40e-03
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	1.90e-02	0.196000	8.57e-02
INOSITOL PHOSPHATE METABOLISM	46	2.20e-02	0.195000	9.45e-02
FCERI MEDIATED MAPK ACTIVATION	28	7.38e-02	-0.195000	2.14e-01
UCH PROTEINASES	90	1.38e-03	-0.195000	1.10e-02
TRANSCRIPTION OF THE HIV GENOME	67	5.96e-03	-0.194000	3.58e-02
FATTY ACID METABOLISM	146	5.12e-05	-0.194000	6.78e-04
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	66	6.36e-03	-0.194000	3.77e-02
ABC TRANSPORTER DISORDERS	71	4.70e-03	-0.194000	3.03e-02
SIGNALING BY ROBO RECEPTORS	210	1.31e-06	-0.194000	3.43e-05
PROGRAMMED CELL DEATH	188	5.07e-06	-0.193000	9.06e-05
MTORC1 MEDIATED SIGNALLING	24	1.02e-01	-0.193000	2.59e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	68	6.05e-03	-0.193000	3.62e-02
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	10	2.93e-01	0.192000	5.10e-01
DNA DAMAGE RECOGNITION IN GG NER	38	4.06e-02	-0.192000	1.43e-01
CHONDROITIN SULFATE BIOSYNTHESIS	18	1.59e-01	0.192000	3.46e-01
RAF ACTIVATION	34	5.30e-02	-0.192000	1.70e-01
PKMTS METHYLATE HISTONE LYSINES	49	2.10e-02	0.191000	9.24e-02
SIALIC ACID METABOLISM	32	6.29e-02	-0.190000	1.91e-01
FATTY ACYL COA BIOSYNTHESIS	32	6.32e-02	-0.190000	1.91e-01
PEROXISOMAL LIPID METABOLISM	26	9.40e-02	-0.190000	2.47e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	2.36e-01	-0.190000	4.46e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	2.77e-01	0.189000	4.92e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS	19	1.53e-01	-0.189000	3.37e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	3.02e-01	0.189000	5.19e-01
INTERFERON SIGNALING	167	2.75e-05	-0.188000	3.95e-04
ANTIMICROBIAL PEPTIDES	17	1.79e-01	-0.188000	3.75e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	2.07e-01	-0.188000	4.09e-01
COSTIMULATION BY THE CD28 FAMILY	50	2.15e-02	-0.188000	9.36e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	23	1.22e-01	-0.186000	2.94e-01
RHOA GTPASE CYCLE	143	1.25e-04	0.186000	1.41e-03
RUNX2 REGULATES BONE DEVELOPMENT	29	8.47e-02	0.185000	2.36e-01
ARACHIDONIC ACID METABOLISM	40	4.34e-02	-0.185000	1.50e-01
IRE1ALPHA ACTIVATES CHAPERONES	50	2.40e-02	0.185000	1.01e-01
PCP CE PATHWAY	90	2.53e-03	-0.184000	1.83e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	1.19e-01	-0.184000	2.87e-01
N GLYCAN ANTENNAE ELONGATION	15	2.18e-01	-0.184000	4.22e-01
DAG AND IP3 SIGNALING	40	4.48e-02	0.183000	1.54e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS	12	2.71e-01	-0.183000	4.86e-01
NUCLEOBASE BIOSYNTHESIS	15	2.21e-01	-0.182000	4.26e-01
RND2 GTPASE CYCLE	39	4.99e-02	0.182000	1.64e-01
G2 M DNA DAMAGE CHECKPOINT	67	1.04e-02	-0.181000	5.55e-02
SARS COV 2 INFECTION	65	1.17e-02	-0.181000	6.11e-02
SEMA4D IN SEMAPHORIN SIGNALING	24	1.26e-01	0.181000	2.97e-01
INTERLEUKIN 20 FAMILY SIGNALING	14	2.42e-01	0.180000	4.53e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	2.60e-01	0.180000	4.74e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	1.35e-01	-0.180000	3.11e-01
SYNTHESIS OF PA	29	9.33e-02	0.180000	2.46e-01
APOPTOSIS	166	6.55e-05	-0.180000	8.30e-04
BIOLOGICAL OXIDATIONS	125	5.38e-04	-0.179000	4.96e-03
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	2.29e-01	-0.179000	4.36e-01
DISEASES OF PROGRAMMED CELL DEATH	55	2.17e-02	-0.179000	9.39e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	2.47e-01	0.179000	4.58e-01
LAMININ INTERACTIONS	28	1.03e-01	0.178000	2.61e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	9.20e-02	0.178000	2.45e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	8.76e-02	-0.177000	2.40e-01
G1 S SPECIFIC TRANSCRIPTION	27	1.11e-01	-0.177000	2.74e-01
CHROMOSOME MAINTENANCE	102	2.03e-03	-0.177000	1.52e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	2.72e-01	-0.176000	4.86e-01
CHAPERONE MEDIATED AUTOPHAGY	21	1.65e-01	-0.175000	3.57e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	23	1.46e-01	-0.175000	3.27e-01
AMINO ACIDS REGULATE MTORC1	51	3.10e-02	-0.175000	1.20e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	61	1.86e-02	0.174000	8.47e-02
TRAFFICKING OF AMPA RECEPTORS	31	9.36e-02	0.174000	2.46e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	38	6.38e-02	-0.174000	1.92e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	14	2.61e-01	-0.174000	4.74e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	9.02e-02	0.173000	2.43e-01
HIV LIFE CYCLE	142	3.78e-04	-0.173000	3.68e-03
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	3.00e-01	0.173000	5.19e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	2.05e-01	0.173000	4.07e-01
MITOTIC PROPHASE	96	3.56e-03	-0.172000	2.37e-02
TELOMERE MAINTENANCE	79	8.20e-03	-0.172000	4.54e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	1.09e-01	0.172000	2.70e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	18	2.07e-01	0.172000	4.09e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	1.84e-01	-0.172000	3.80e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	5.78e-02	0.171000	1.80e-01
MET PROMOTES CELL MOTILITY	38	6.80e-02	0.171000	2.00e-01
NEDDYLATION	221	1.21e-05	-0.171000	1.88e-04
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	3.50e-01	-0.171000	5.66e-01
BETA CATENIN PHOSPHORYLATION CASCADE	16	2.38e-01	-0.171000	4.47e-01
SEMAPHORIN INTERACTIONS	64	1.85e-02	0.170000	8.47e-02
RHO GTPASES ACTIVATE KTN1	11	3.30e-01	-0.169000	5.44e-01
LATE ENDOSOMAL MICROAUTOPHAGY	32	9.81e-02	-0.169000	2.54e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	1.09e-01	-0.169000	2.70e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	2.15e-01	0.169000	4.18e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	13	2.92e-01	-0.169000	5.10e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	8.91e-02	-0.169000	2.42e-01
CARGO CONCENTRATION IN THE ER	31	1.05e-01	-0.168000	2.65e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	2.17e-01	0.168000	4.20e-01
CROSSLINKING OF COLLAGEN FIBRILS	16	2.45e-01	0.168000	4.57e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	1.39e-01	-0.168000	3.18e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	12	3.16e-01	0.167000	5.31e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	3.38e-01	-0.167000	5.52e-01
GLUCAGON TYPE LIGAND RECEPTORS	26	1.41e-01	-0.167000	3.20e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING	10	3.61e-01	-0.167000	5.73e-01
RAC1 GTPASE CYCLE	179	1.22e-04	0.167000	1.40e-03
INFLAMMASOMES	18	2.21e-01	-0.167000	4.26e-01
SHC1 EVENTS IN EGFR SIGNALING	11	3.40e-01	-0.166000	5.54e-01
MITOTIC SPINDLE CHECKPOINT	96	4.99e-03	-0.166000	3.15e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	3.01e-01	0.166000	5.19e-01
INITIAL TRIGGERING OF COMPLEMENT	13	3.05e-01	0.164000	5.21e-01
PI 3K CASCADE FGFR2	17	2.41e-01	-0.164000	4.51e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	3.53e-02	-0.164000	1.29e-01
FGFR2 LIGAND BINDING AND ACTIVATION	13	3.06e-01	-0.164000	5.22e-01
G ALPHA 12 13 SIGNALLING EVENTS	75	1.41e-02	0.164000	7.01e-02
CD28 CO STIMULATION	31	1.15e-01	-0.164000	2.79e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	110	3.08e-03	-0.163000	2.10e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	1.66e-01	-0.163000	3.59e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	1.96e-01	-0.163000	3.98e-01
DEADENYLATION OF MRNA	25	1.59e-01	-0.163000	3.46e-01
DAP12 INTERACTIONS	30	1.23e-01	-0.163000	2.94e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	1.06e-01	-0.163000	2.65e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	64	2.53e-02	0.162000	1.05e-01
CYTOSOLIC TRNA AMINOACYLATION	24	1.71e-01	-0.162000	3.62e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	3.54e-01	-0.161000	5.69e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	3.14e-01	0.161000	5.31e-01
HDMS DEMETHYLATE HISTONES	28	1.41e-01	0.161000	3.20e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	87	9.70e-03	0.160000	5.25e-02
SIGNALING BY INSULIN RECEPTOR	64	2.66e-02	-0.160000	1.08e-01
NUCLEAR ENVELOPE NE REASSEMBLY	65	2.55e-02	-0.160000	1.06e-01
TRANSCRIPTIONAL REGULATION BY MECP2	60	3.21e-02	0.160000	1.22e-01
SCAVENGING OF HEME FROM PLASMA	11	3.59e-01	-0.160000	5.70e-01
CTLA4 INHIBITORY SIGNALING	20	2.17e-01	-0.160000	4.20e-01
SENSORY PROCESSING OF SOUND	61	3.17e-02	0.159000	1.22e-01
RND3 GTPASE CYCLE	38	9.17e-02	0.158000	2.45e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	2.10e-01	0.158000	4.11e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	3.65e-01	-0.158000	5.76e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	9.71e-02	-0.158000	2.52e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	2.47e-01	0.158000	4.59e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	8.14e-02	-0.157000	2.29e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	3.46e-01	0.157000	5.60e-01
SPHINGOLIPID METABOLISM	79	1.62e-02	-0.156000	7.75e-02
CELL CYCLE MITOTIC	476	5.41e-09	-0.156000	3.36e-07
PI 3K CASCADE FGFR1	16	2.80e-01	-0.156000	4.96e-01
DISEASES OF GLYCOSYLATION	126	2.49e-03	0.156000	1.81e-02
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	1.05e-01	0.156000	2.65e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	3.15e-01	0.155000	5.31e-01
BASE EXCISION REPAIR	57	4.29e-02	-0.155000	1.49e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	2.69e-01	0.155000	4.83e-01
GLYCOSPHINGOLIPID METABOLISM	38	9.86e-02	-0.155000	2.54e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	2.71e-01	-0.154000	4.86e-01
G PROTEIN MEDIATED EVENTS	51	5.75e-02	0.154000	1.79e-01
PLATELET SENSITIZATION BY LDL	15	3.03e-01	-0.154000	5.20e-01
NEUTROPHIL DEGRANULATION	393	1.82e-07	-0.154000	6.71e-06
FRS MEDIATED FGFR2 SIGNALING	19	2.47e-01	-0.154000	4.58e-01
METABOLISM OF RNA	646	3.85e-11	-0.153000	5.68e-09
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	3.82e-02	-0.152000	1.37e-01
SYNTHESIS OF PE	13	3.42e-01	0.152000	5.57e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	3.83e-01	-0.152000	5.94e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	3.43e-01	-0.152000	5.57e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	1.98e-01	-0.152000	4.02e-01
GPVI MEDIATED ACTIVATION CASCADE	31	1.45e-01	-0.151000	3.24e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	119	4.49e-03	0.151000	2.92e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT	96	1.07e-02	-0.151000	5.70e-02
M PHASE	342	1.75e-06	-0.151000	4.18e-05
RHOBTB2 GTPASE CYCLE	23	2.11e-01	-0.151000	4.12e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	1.76e-01	-0.150000	3.69e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	607	3.18e-10	-0.150000	2.88e-08
METABOLISM OF NUCLEOTIDES	92	1.30e-02	-0.150000	6.52e-02
FCGR3A MEDIATED IL10 SYNTHESIS	32	1.42e-01	0.150000	3.22e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	3.15e-01	-0.150000	5.31e-01
MUCOPOLYSACCHARIDOSES	11	3.91e-01	0.150000	6.00e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	1.72e-01	-0.149000	3.64e-01
HIV TRANSCRIPTION ELONGATION	42	9.51e-02	-0.149000	2.49e-01
PRE NOTCH EXPRESSION AND PROCESSING	65	3.80e-02	0.149000	1.37e-01
GAP JUNCTION ASSEMBLY	21	2.39e-01	-0.148000	4.49e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	3.58e-01	0.147000	5.70e-01
NEGATIVE REGULATION OF MAPK PATHWAY	42	9.88e-02	-0.147000	2.54e-01
TRNA PROCESSING IN THE NUCLEUS	56	5.69e-02	-0.147000	1.78e-01
NICOTINATE METABOLISM	25	2.03e-01	-0.147000	4.07e-01
RA BIOSYNTHESIS PATHWAY	15	3.25e-01	-0.147000	5.38e-01
HSF1 ACTIVATION	26	1.95e-01	-0.147000	3.98e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	3.10e-01	-0.146000	5.26e-01
PURINE SALVAGE	12	3.81e-01	-0.146000	5.93e-01
CHROMATIN MODIFYING ENZYMES	221	1.86e-04	0.146000	1.96e-03
FRS MEDIATED FGFR1 SIGNALING	18	2.84e-01	-0.146000	5.01e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	352	3.01e-06	-0.145000	6.56e-05
RMTS METHYLATE HISTONE ARGININES	44	9.59e-02	0.145000	2.50e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	1.27e-01	0.145000	3.00e-01
FLT3 SIGNALING IN DISEASE	28	1.88e-01	0.144000	3.85e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	3.35e-01	-0.144000	5.51e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	2.91e-01	-0.144000	5.08e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	16	3.20e-01	-0.144000	5.33e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	8.64e-02	-0.143000	2.38e-01
INTERLEUKIN 6 FAMILY SIGNALING	20	2.69e-01	0.143000	4.83e-01
RET SIGNALING	37	1.33e-01	0.143000	3.08e-01
SIGNALING BY FGFR4 IN DISEASE	11	4.14e-01	-0.142000	6.24e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	73	3.58e-02	0.142000	1.30e-01
REGULATION OF IFNG SIGNALING	13	3.76e-01	-0.142000	5.89e-01
ASPARAGINE N LINKED GLYCOSYLATION	285	3.97e-05	-0.142000	5.50e-04
COLLAGEN FORMATION	81	2.83e-02	0.141000	1.13e-01
CELL CYCLE	594	5.02e-09	-0.141000	3.29e-07
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	2.64e-01	0.141000	4.78e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	1.07e-01	-0.141000	2.65e-01
NEUROTRANSMITTER RELEASE CYCLE	49	8.89e-02	0.141000	2.42e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	17	3.18e-01	0.140000	5.31e-01
RESOLUTION OF ABASIC SITES AP SITES	37	1.43e-01	-0.139000	3.22e-01
IRAK4 DEFICIENCY TLR2 4	15	3.53e-01	-0.139000	5.68e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	3.56e-01	0.138000	5.69e-01
TRANS GOLGI NETWORK VESICLE BUDDING	70	4.67e-02	-0.138000	1.57e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	3.28e-01	-0.137000	5.40e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	7.71e-02	0.137000	2.20e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	32	1.81e-01	-0.137000	3.77e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	3.76e-01	-0.137000	5.89e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	1.17e-01	-0.136000	2.85e-01
RNA POLYMERASE I TRANSCRIPTION	68	5.23e-02	-0.136000	1.68e-01
LONG TERM POTENTIATION	23	2.59e-01	0.136000	4.74e-01
HCMV LATE EVENTS	66	5.64e-02	-0.136000	1.78e-01
EXTENSION OF TELOMERES	49	1.01e-01	-0.135000	2.57e-01
CD209 DC SIGN SIGNALING	18	3.22e-01	-0.135000	5.34e-01
RHOV GTPASE CYCLE	33	1.80e-01	0.135000	3.76e-01
BIOTIN TRANSPORT AND METABOLISM	11	4.39e-01	0.135000	6.50e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	12	4.19e-01	-0.135000	6.30e-01
RESOLUTION OF SISTER CHROMATID COHESION	102	1.90e-02	-0.135000	8.57e-02
RHOU GTPASE CYCLE	34	1.75e-01	0.134000	3.68e-01
MRNA SPLICING MINOR PATHWAY	52	9.37e-02	-0.134000	2.46e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	2.11e-01	-0.134000	4.12e-01
INNATE IMMUNE SYSTEM	792	1.73e-10	-0.134000	1.85e-08
INFECTIOUS DISEASE	737	7.05e-10	-0.134000	5.54e-08
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	2.68e-01	0.133000	4.83e-01
PROTEIN FOLDING	89	2.99e-02	-0.133000	1.17e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	74	4.79e-02	-0.133000	1.59e-01
INTEGRIN SIGNALING	24	2.59e-01	0.133000	4.74e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	71	5.35e-02	-0.133000	1.71e-01
TP53 REGULATES METABOLIC GENES	87	3.35e-02	-0.132000	1.25e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	290	1.17e-04	-0.132000	1.35e-03
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	20	3.08e-01	-0.132000	5.24e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	9.13e-02	-0.132000	2.45e-01
EPHB MEDIATED FORWARD SIGNALING	42	1.41e-01	-0.131000	3.20e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	13	4.13e-01	-0.131000	6.23e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	18	3.36e-01	-0.131000	5.51e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	2.48e-01	0.131000	4.59e-01
PROLONGED ERK ACTIVATION EVENTS	14	3.97e-01	-0.131000	6.09e-01
AMYLOID FIBER FORMATION	58	8.54e-02	-0.131000	2.37e-01
TOLL LIKE RECEPTOR CASCADES	141	7.48e-03	-0.131000	4.24e-02
ONCOGENE INDUCED SENESCENCE	32	2.02e-01	0.130000	4.07e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	2.28e-01	-0.129000	4.35e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	1.52e-01	0.129000	3.36e-01
STIMULI SENSING CHANNELS	76	5.15e-02	0.129000	1.67e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	4.41e-01	0.129000	6.51e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	4.82e-01	0.129000	6.87e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	4.82e-01	0.129000	6.87e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	108	2.13e-02	0.128000	9.34e-02
PLATELET CALCIUM HOMEOSTASIS	26	2.60e-01	0.128000	4.74e-01
METABOLISM OF FAT SOLUBLE VITAMINS	33	2.05e-01	0.127000	4.07e-01
MEIOTIC RECOMBINATION	39	1.69e-01	-0.127000	3.61e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	553	3.83e-07	-0.127000	1.25e-05
NON INTEGRIN MEMBRANE ECM INTERACTIONS	56	1.01e-01	0.127000	2.57e-01
FOXO MEDIATED TRANSCRIPTION	59	9.28e-02	-0.127000	2.46e-01
L1CAM INTERACTIONS	107	2.39e-02	0.126000	1.01e-01
REGULATION OF TNFR1 SIGNALING	34	2.02e-01	0.126000	4.07e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	22	3.07e-01	-0.126000	5.23e-01
SNRNP ASSEMBLY	51	1.20e-01	-0.126000	2.90e-01
EXTRACELLULAR MATRIX ORGANIZATION	247	6.90e-04	0.126000	6.21e-03
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	4.34e-01	0.125000	6.45e-01
PEXOPHAGY	11	4.73e-01	0.125000	6.82e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	22	3.11e-01	-0.125000	5.26e-01
METABOLISM OF AMINE DERIVED HORMONES	10	4.95e-01	0.125000	6.96e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	28	2.54e-01	-0.125000	4.66e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	48	1.36e-01	-0.125000	3.13e-01
RHO GTPASES ACTIVATE IQGAPS	24	2.91e-01	-0.125000	5.08e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	29	2.47e-01	0.124000	4.58e-01
PRC2 METHYLATES HISTONES AND DNA	30	2.40e-01	-0.124000	4.49e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	1.99e-01	-0.124000	4.03e-01
GLUCONEOGENESIS	27	2.67e-01	-0.124000	4.81e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	14	4.24e-01	0.123000	6.34e-01
AUTOPHAGY	140	1.20e-02	-0.123000	6.18e-02
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	171	5.58e-03	-0.123000	3.39e-02
INWARDLY RECTIFYING K CHANNELS	32	2.31e-01	-0.122000	4.37e-01
SIGNALING BY FLT3 FUSION PROTEINS	19	3.58e-01	0.122000	5.70e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	5.06e-01	-0.121000	7.02e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	26	2.84e-01	-0.121000	5.01e-01
METABOLISM OF STEROID HORMONES	21	3.37e-01	-0.121000	5.51e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	179	5.24e-03	-0.121000	3.21e-02
RESPONSE OF MTB TO PHAGOCYTOSIS	21	3.39e-01	-0.121000	5.52e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	64	9.55e-02	-0.121000	2.50e-01
RHO GTPASES ACTIVATE PKNS	48	1.51e-01	-0.120000	3.35e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	2.73e-01	-0.120000	4.86e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	1.28e-01	0.120000	3.00e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	7.78e-02	-0.119000	2.21e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	94	4.56e-02	-0.119000	1.54e-01
P75NTR SIGNALS VIA NF KB	16	4.09e-01	0.119000	6.20e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	1.13e-01	-0.119000	2.78e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	53	1.34e-01	0.119000	3.11e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	3.46e-01	-0.119000	5.60e-01
MITOTIC G2 G2 M PHASES	187	5.12e-03	-0.119000	3.19e-02
MTOR SIGNALLING	41	1.90e-01	-0.118000	3.87e-01
SIGNALING BY NOTCH1	75	7.64e-02	0.118000	2.19e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	27	2.87e-01	-0.118000	5.05e-01
SENSORY PERCEPTION	153	1.20e-02	0.118000	6.18e-02
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	62	1.09e-01	-0.118000	2.70e-01
SIGNALING BY RETINOIC ACID	35	2.28e-01	-0.118000	4.35e-01
INTERLEUKIN 17 SIGNALING	68	9.34e-02	-0.118000	2.46e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	1.42e-01	-0.118000	3.22e-01
NEURONAL SYSTEM	373	1.01e-04	0.117000	1.21e-03
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	4.82e-01	-0.117000	6.87e-01
INTERLEUKIN 1 FAMILY SIGNALING	123	2.48e-02	-0.117000	1.04e-01
HEME SIGNALING	46	1.69e-01	0.117000	3.61e-01
REGULATION OF IFNA SIGNALING	12	4.82e-01	0.117000	6.87e-01
GENERATION OF SECOND MESSENGER MOLECULES	19	3.79e-01	-0.117000	5.92e-01
RHO GTPASES ACTIVATE PAKS	21	3.56e-01	0.116000	5.69e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	2.55e-01	-0.116000	4.67e-01
INTERLEUKIN 10 SIGNALING	19	3.81e-01	-0.116000	5.93e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	4.70e-01	0.116000	6.80e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	5.28e-01	0.115000	7.22e-01
NEGATIVE REGULATION OF FLT3	14	4.57e-01	0.115000	6.68e-01
SIGNAL AMPLIFICATION	30	2.80e-01	-0.114000	4.96e-01
DNA METHYLATION	21	3.66e-01	-0.114000	5.78e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	3.68e-01	-0.113000	5.79e-01
RHO GTPASES ACTIVATE FORMINS	118	3.36e-02	-0.113000	1.25e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	4.97e-01	-0.113000	6.98e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	32	2.68e-01	0.113000	4.83e-01
TNF SIGNALING	43	2.00e-01	0.113000	4.05e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.00e-01	0.112000	7.00e-01
MYD88 INDEPENDENT TLR4 CASCADE	94	5.96e-02	-0.112000	1.84e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	142	2.09e-02	-0.112000	9.24e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	4.52e-01	0.112000	6.65e-01
TBC RABGAPS	43	2.04e-01	-0.112000	4.07e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	4.68e-01	0.112000	6.79e-01
TIE2 SIGNALING	17	4.24e-01	-0.112000	6.34e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	4.68e-01	0.112000	6.79e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	4.25e-01	0.112000	6.34e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	4.00e-01	0.112000	6.10e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	2.83e-01	0.111000	5.00e-01
O LINKED GLYCOSYLATION	88	7.13e-02	0.111000	2.09e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	3.17e-01	0.111000	5.31e-01
G ALPHA Z SIGNALLING EVENTS	44	2.04e-01	-0.111000	4.07e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	97	5.96e-02	0.111000	1.84e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	4.89e-01	-0.111000	6.93e-01
COHESIN LOADING ONTO CHROMATIN	10	5.45e-01	-0.111000	7.38e-01
ADAPTIVE IMMUNE SYSTEM	614	3.69e-06	-0.110000	7.78e-05
ACYL CHAIN REMODELLING OF PS	14	4.78e-01	-0.110000	6.87e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	53	1.68e-01	-0.110000	3.60e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1230	1.90e-10	-0.109000	1.87e-08
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	3.67e-01	0.109000	5.78e-01
DNA REPAIR	292	1.47e-03	-0.108000	1.15e-02
ASSEMBLY OF THE HIV VIRION	16	4.55e-01	-0.108000	6.67e-01
LYSINE CATABOLISM	11	5.37e-01	0.107000	7.32e-01
INTEGRATION OF ENERGY METABOLISM	99	6.50e-02	0.107000	1.94e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	4.58e-01	-0.107000	6.70e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	140	2.89e-02	-0.107000	1.15e-01
ION HOMEOSTASIS	51	1.87e-01	0.107000	3.84e-01
GLUTAMATE AND GLUTAMINE METABOLISM	13	5.06e-01	0.107000	7.02e-01
TRNA PROCESSING	105	6.03e-02	-0.106000	1.84e-01
RHOH GTPASE CYCLE	37	2.64e-01	-0.106000	4.78e-01
ION CHANNEL TRANSPORT	144	2.83e-02	0.106000	1.13e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	22	3.92e-01	-0.105000	6.02e-01
DISEASES OF METABOLISM	200	1.10e-02	0.104000	5.81e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS	11	5.50e-01	0.104000	7.40e-01
BASE EXCISION REPAIR AP SITE FORMATION	30	3.23e-01	-0.104000	5.36e-01
PEPTIDE HORMONE METABOLISM	60	1.67e-01	-0.103000	3.59e-01
LYSOSOME VESICLE BIOGENESIS	33	3.07e-01	-0.103000	5.23e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	64	1.55e-01	-0.103000	3.39e-01
FLT3 SIGNALING	36	2.88e-01	0.102000	5.05e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	13	5.23e-01	0.102000	7.16e-01
SMOOTH MUSCLE CONTRACTION	33	3.09e-01	0.102000	5.26e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	4.30e-01	0.102000	6.39e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	4.94e-01	-0.102000	6.96e-01
PLATELET AGGREGATION PLUG FORMATION	32	3.19e-01	0.102000	5.32e-01
AQUAPORIN MEDIATED TRANSPORT	42	2.56e-01	-0.101000	4.68e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	4.22e-01	0.101000	6.32e-01
DISEASES OF DNA REPAIR	11	5.61e-01	0.101000	7.51e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	2.25e-01	-0.100000	4.30e-01
UB SPECIFIC PROCESSING PROTEASES	169	2.48e-02	-0.100000	1.04e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	21	4.27e-01	-0.100000	6.36e-01
HOMOLOGY DIRECTED REPAIR	107	7.43e-02	-0.099900	2.15e-01
CA DEPENDENT EVENTS	36	3.01e-01	0.099600	5.19e-01
PTEN REGULATION	136	4.56e-02	-0.099400	1.54e-01
NETRIN 1 SIGNALING	50	2.25e-01	0.099300	4.30e-01
COLLAGEN CHAIN TRIMERIZATION	41	2.73e-01	0.099000	4.86e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	4.80e-01	-0.098900	6.87e-01
PARASITE INFECTION	54	2.10e-01	-0.098600	4.11e-01
HEDGEHOG ON STATE	83	1.22e-01	-0.098300	2.93e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	64	1.74e-01	-0.098300	3.67e-01
SIGNALING BY INTERLEUKINS	353	1.55e-03	-0.098300	1.20e-02
P38MAPK EVENTS	13	5.41e-01	-0.098000	7.35e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	51	2.27e-01	0.097800	4.34e-01
MEIOSIS	66	1.71e-01	-0.097500	3.62e-01
ACYL CHAIN REMODELLING OF PC	17	4.87e-01	0.097300	6.90e-01
RHO GTPASE CYCLE	426	6.19e-04	0.096900	5.61e-03
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	27	3.84e-01	-0.096800	5.94e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	4.12e-01	-0.096700	6.23e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	94	1.06e-01	0.096500	2.65e-01
ELASTIC FIBRE FORMATION	38	3.05e-01	0.096300	5.21e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	5.48e-01	-0.096100	7.40e-01
ESR MEDIATED SIGNALING	168	3.18e-02	-0.096100	1.22e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	108	8.70e-02	0.095400	2.39e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	5.85e-01	0.095200	7.69e-01
PLASMA LIPOPROTEIN CLEARANCE	28	3.84e-01	0.095200	5.94e-01
REGULATION OF INSULIN SECRETION	71	1.69e-01	0.094400	3.61e-01
MRNA SPLICING	188	2.63e-02	-0.094100	1.07e-01
RHO GTPASES ACTIVATE CIT	18	4.91e-01	0.093700	6.94e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	109	9.14e-02	0.093600	2.45e-01
SIGNALING BY WNT	270	8.50e-03	-0.093200	4.66e-02
DEUBIQUITINATION	243	1.29e-02	-0.092800	6.52e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	29	3.88e-01	-0.092700	5.98e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	4.86e-01	-0.092300	6.90e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	3.99e-01	-0.092100	6.10e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	2.22e-01	0.091900	4.27e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	76	1.67e-01	-0.091800	3.59e-01
SIGNAL TRANSDUCTION BY L1	21	4.71e-01	-0.090900	6.80e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	95	1.28e-01	-0.090300	3.00e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	5.90e-01	0.089900	7.72e-01
APOPTOTIC EXECUTION PHASE	45	2.98e-01	-0.089800	5.17e-01
NONHOMOLOGOUS END JOINING NHEJ	44	3.04e-01	-0.089500	5.21e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	92	1.40e-01	-0.089100	3.19e-01
KERATAN SULFATE BIOSYNTHESIS	24	4.52e-01	-0.088700	6.65e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	4.01e-01	-0.088500	6.10e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	3.79e-01	-0.088400	5.92e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	5.82e-01	-0.088200	7.68e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	5.42e-01	-0.088100	7.35e-01
SARS COV INFECTIONS	141	7.15e-02	-0.088000	2.09e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	1.57e-01	-0.087800	3.44e-01
SIGNALING BY FGFR1	44	3.14e-01	-0.087700	5.31e-01
MEIOTIC SYNAPSIS	42	3.26e-01	-0.087600	5.39e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	6.00e-01	-0.087500	7.80e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	74	1.96e-01	0.086900	3.99e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	5.48e-01	-0.086700	7.40e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	2.22e-02	-0.086400	9.50e-02
SIGNALING BY MET	74	2.04e-01	0.085400	4.07e-01
SELECTIVE AUTOPHAGY	73	2.08e-01	-0.085300	4.09e-01
DAP12 SIGNALING	24	4.71e-01	-0.085100	6.80e-01
FGFR2 ALTERNATIVE SPLICING	25	4.62e-01	-0.085000	6.73e-01
RHO GTPASES ACTIVATE ROCKS	19	5.23e-01	0.084700	7.16e-01
TRANSCRIPTIONAL REGULATION BY TP53	346	6.94e-03	-0.084600	4.03e-02
HYALURONAN UPTAKE AND DEGRADATION	12	6.13e-01	0.084300	7.85e-01
IRS MEDIATED SIGNALLING	40	3.58e-01	-0.084000	5.70e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	148	7.81e-02	-0.084000	2.21e-01
METABOLISM OF FOLATE AND PTERINES	15	5.74e-01	0.083900	7.62e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	3.16e-01	0.083700	5.31e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	3.74e-01	-0.083400	5.86e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	6.18e-01	-0.083100	7.87e-01
SIGNALING BY FGFR IN DISEASE	57	2.78e-01	-0.083100	4.94e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	24	4.82e-01	-0.082900	6.87e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	4.92e-01	0.082800	6.94e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	3.27e-01	-0.082700	5.39e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	5.03e-01	-0.082400	7.01e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	6.07e-01	-0.082400	7.82e-01
RNA POLYMERASE II TRANSCRIPTION	1100	4.94e-06	-0.082100	9.06e-05
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	3.20e-01	0.082100	5.33e-01
SIGNALING BY NTRKS	130	1.07e-01	-0.082000	2.65e-01
PECAM1 INTERACTIONS	12	6.24e-01	0.081700	7.92e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	4.47e-01	0.081600	6.59e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	2.89e-01	-0.081200	5.07e-01
HDACS DEACETYLATE HISTONES	47	3.36e-01	0.081100	5.51e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	91	1.82e-01	-0.081000	3.77e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	106	1.50e-01	-0.081000	3.34e-01
DEATH RECEPTOR SIGNALLING	133	1.07e-01	0.080900	2.67e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	5.13e-01	-0.080500	7.09e-01
SIGNALING BY ERBB2	48	3.37e-01	-0.080100	5.52e-01
IRAK1 RECRUITS IKK COMPLEX	14	6.05e-01	0.079800	7.82e-01
ERBB2 ACTIVATES PTK6 SIGNALING	11	6.47e-01	0.079700	8.11e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	245	3.22e-02	0.079600	1.22e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	6.49e-01	0.079200	8.11e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	2.01e-01	-0.078900	4.05e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	6.66e-01	-0.078800	8.19e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	3.84e-01	0.078600	5.94e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	45	3.63e-01	-0.078400	5.74e-01
SIGNALING BY NOTCH3	48	3.48e-01	0.078300	5.63e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	96	1.86e-01	-0.078100	3.84e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	2.53e-01	-0.078000	4.65e-01
HCMV INFECTION	104	1.70e-01	-0.077900	3.61e-01
METAL ION SLC TRANSPORTERS	25	5.01e-01	0.077800	7.00e-01
POLO LIKE KINASE MEDIATED EVENTS	14	6.16e-01	-0.077400	7.86e-01
SIGNALING BY EGFR	47	3.59e-01	0.077300	5.70e-01
MYOGENESIS	25	5.04e-01	0.077200	7.01e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	24	5.15e-01	-0.076800	7.09e-01
MHC CLASS II ANTIGEN PRESENTATION	101	1.83e-01	-0.076800	3.79e-01
CELL CELL JUNCTION ORGANIZATION	49	3.53e-01	-0.076800	5.68e-01
KERATAN SULFATE DEGRADATION	11	6.60e-01	0.076600	8.18e-01
G ALPHA S SIGNALLING EVENTS	108	1.69e-01	0.076600	3.61e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	6.47e-01	-0.076400	8.11e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	4.37e-01	-0.075900	6.48e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	93	2.08e-01	-0.075700	4.09e-01
SIGNALING BY NODAL	15	6.12e-01	-0.075500	7.85e-01
SHC MEDIATED CASCADE FGFR4	12	6.51e-01	-0.075300	8.12e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	5.64e-01	0.074600	7.53e-01
COMPLEMENT CASCADE	27	5.04e-01	0.074300	7.01e-01
SIGNALING BY TGFB FAMILY MEMBERS	97	2.09e-01	-0.073900	4.10e-01
KILLING MECHANISMS	11	6.72e-01	0.073700	8.25e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	5.44e-01	-0.073100	7.37e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	26	5.20e-01	0.072900	7.14e-01
SIGNALLING TO ERKS	34	4.63e-01	-0.072800	6.74e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	27	5.13e-01	-0.072700	7.09e-01
RHOBTB GTPASE CYCLE	35	4.59e-01	-0.072300	6.70e-01
PYRIMIDINE SALVAGE	10	6.93e-01	0.072200	8.36e-01
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION	10	6.93e-01	0.072100	8.36e-01
RHOJ GTPASE CYCLE	55	3.56e-01	0.071900	5.69e-01
HSF1 DEPENDENT TRANSACTIVATION	34	4.72e-01	0.071200	6.82e-01
RAB REGULATION OF TRAFFICKING	118	1.84e-01	-0.070800	3.80e-01
MUSCLE CONTRACTION	164	1.18e-01	0.070800	2.86e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	195	8.91e-02	0.070700	2.42e-01
PROLACTIN RECEPTOR SIGNALING	11	6.85e-01	-0.070600	8.32e-01
DEFECTS IN COBALAMIN B12 METABOLISM	13	6.60e-01	-0.070500	8.18e-01
CELLULAR RESPONSE TO HEAT STRESS	95	2.35e-01	-0.070500	4.44e-01
OTHER INTERLEUKIN SIGNALING	20	5.86e-01	0.070400	7.69e-01
SIGNALING BY EGFR IN CANCER	22	5.68e-01	-0.070300	7.58e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	27	5.34e-01	-0.069200	7.29e-01
VLDLR INTERNALISATION AND DEGRADATION	12	6.79e-01	0.069000	8.28e-01
SIGNALING BY NUCLEAR RECEPTORS	227	7.38e-02	-0.069000	2.14e-01
ENDOGENOUS STEROLS	20	5.95e-01	0.068600	7.76e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	5.96e-01	-0.068500	7.76e-01
GAP JUNCTION DEGRADATION	11	6.95e-01	-0.068200	8.38e-01
RAP1 SIGNALLING	15	6.48e-01	-0.068000	8.11e-01
COLLAGEN DEGRADATION	51	4.01e-01	0.068000	6.10e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	6.84e-01	-0.067900	8.31e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	2.98e-01	-0.067800	5.18e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	5.35e-01	-0.067700	7.29e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	36	4.82e-01	0.067700	6.87e-01
REDUCTION OF CYTOSOLIC CA LEVELS	12	6.86e-01	0.067500	8.32e-01
RHO GTPASE EFFECTORS	252	6.81e-02	-0.066800	2.00e-01
SIGNALING BY FGFR	75	3.19e-01	-0.066600	5.32e-01
SIGNALING BY NOTCH2	33	5.08e-01	0.066600	7.04e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	4.55e-01	0.066600	6.67e-01
INSULIN RECEPTOR SIGNALLING CASCADE	45	4.40e-01	-0.066600	6.51e-01
VXPX CARGO TARGETING TO CILIUM	19	6.16e-01	0.066400	7.86e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	5.82e-01	-0.066300	7.68e-01
CILIUM ASSEMBLY	193	1.14e-01	0.066100	2.79e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	6.10e-01	0.066000	7.85e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	6.51e-01	-0.065400	8.12e-01
TRP CHANNELS	20	6.13e-01	0.065300	7.85e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	14	6.73e-01	0.065100	8.25e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	4.53e-01	-0.064700	6.65e-01
SIGNALING BY FGFR2	64	3.71e-01	-0.064600	5.83e-01
RHOBTB1 GTPASE CYCLE	23	5.92e-01	-0.064600	7.73e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	5.70e-01	0.064400	7.59e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	5.54e-01	-0.063400	7.44e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	6.82e-01	0.063200	8.31e-01
POTASSIUM CHANNELS	91	2.98e-01	0.063100	5.18e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	7.19e-01	-0.062700	8.54e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	5.81e-01	0.062600	7.68e-01
ER QUALITY CONTROL COMPARTMENT ERQC	21	6.22e-01	-0.062200	7.91e-01
SIGNALING BY KIT IN DISEASE	20	6.31e-01	-0.062100	7.96e-01
OVARIAN TUMOR DOMAIN PROTEASES	37	5.15e-01	-0.061900	7.09e-01
GLYCOSAMINOGLYCAN METABOLISM	115	2.52e-01	0.061800	4.65e-01
TRIGLYCERIDE BIOSYNTHESIS	10	7.39e-01	-0.060900	8.66e-01
PHOSPHOLIPID METABOLISM	187	1.52e-01	0.060800	3.36e-01
VIRAL MESSENGER RNA SYNTHESIS	42	4.96e-01	-0.060700	6.97e-01
SIGNALING BY PDGF	57	4.28e-01	0.060700	6.38e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	7.06e-01	0.060500	8.45e-01
RHOQ GTPASE CYCLE	59	4.22e-01	0.060500	6.32e-01
CLATHRIN MEDIATED ENDOCYTOSIS	133	2.29e-01	-0.060400	4.36e-01
REGULATION OF KIT SIGNALING	16	6.76e-01	0.060400	8.26e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	62	4.13e-01	-0.060200	6.23e-01
SIGNALING BY BMP	25	6.03e-01	-0.060100	7.80e-01
GAB1 SIGNALOSOME	14	6.97e-01	0.060000	8.39e-01
REGULATED PROTEOLYSIS OF P75NTR	12	7.19e-01	0.059900	8.54e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	222	1.25e-01	-0.059900	2.96e-01
SIGNALING BY GPCR	486	2.43e-02	0.059800	1.02e-01
ONCOGENIC MAPK SIGNALING	76	3.68e-01	0.059800	5.79e-01
VITAMIN B5 PANTOTHENATE METABOLISM	15	6.91e-01	-0.059300	8.35e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	7.34e-01	-0.059200	8.63e-01
KERATAN SULFATE KERATIN METABOLISM	30	5.75e-01	-0.059200	7.62e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	63	4.17e-01	-0.059100	6.27e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	26	6.02e-01	-0.059100	7.80e-01
ATTENUATION PHASE	24	6.17e-01	0.059100	7.86e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	4.81e-01	-0.058800	6.87e-01
INTRAFLAGELLAR TRANSPORT	52	4.65e-01	0.058600	6.76e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	5.50e-01	-0.058300	7.40e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	70	4.00e-01	0.058200	6.10e-01
MITOTIC PROMETAPHASE	177	1.84e-01	-0.057900	3.80e-01
CARDIAC CONDUCTION	109	3.01e-01	0.057400	5.19e-01
DNA DOUBLE STRAND BREAK REPAIR	136	2.52e-01	-0.056900	4.65e-01
SIGNALING BY NTRK2 TRKB	24	6.30e-01	0.056700	7.96e-01
SPRY REGULATION OF FGF SIGNALING	16	6.97e-01	-0.056100	8.39e-01
MICRORNA MIRNA BIOGENESIS	24	6.36e-01	0.055900	7.99e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	32	5.85e-01	-0.055800	7.69e-01
METABOLISM OF LIPIDS	616	1.86e-02	-0.055800	8.47e-02
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	6.67e-01	-0.055700	8.19e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	6.24e-01	-0.055600	7.92e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	6.75e-01	-0.055600	8.26e-01
AMINE LIGAND BINDING RECEPTORS	28	6.11e-01	0.055600	7.85e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	11	7.50e-01	0.055500	8.74e-01
SYNDECAN INTERACTIONS	26	6.25e-01	0.055500	7.92e-01
RNA POLYMERASE III TRANSCRIPTION	41	5.41e-01	-0.055200	7.35e-01
PYRIMIDINE CATABOLISM	10	7.64e-01	-0.054900	8.83e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	6.50e-01	-0.054700	8.11e-01
BASIGIN INTERACTIONS	22	6.58e-01	-0.054600	8.17e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	6.91e-01	-0.054100	8.35e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	38	5.64e-01	-0.054100	7.53e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	6.63e-01	-0.053700	8.19e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	7.12e-01	0.053400	8.50e-01
ESTROGEN DEPENDENT GENE EXPRESSION	104	3.52e-01	-0.052900	5.68e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	7.42e-01	0.052800	8.67e-01
MEMBRANE TRAFFICKING	581	3.20e-02	-0.052200	1.22e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	16	7.20e-01	0.051700	8.54e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	6.02e-01	-0.051700	7.80e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	18	7.06e-01	-0.051400	8.45e-01
HATS ACETYLATE HISTONES	94	3.90e-01	0.051300	6.00e-01
MITOCHONDRIAL BIOGENESIS	93	4.02e-01	-0.050300	6.10e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	6.06e-01	0.050300	7.82e-01
METABOLISM OF STEROIDS	115	3.55e-01	0.049900	5.69e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	5.02e-01	-0.049700	7.01e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	6.64e-01	-0.049300	8.19e-01
CALNEXIN CALRETICULIN CYCLE	26	6.64e-01	-0.049200	8.19e-01
VESICLE MEDIATED TRANSPORT	614	4.16e-02	-0.048300	1.45e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	7.92e-01	-0.048100	9.01e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	104	3.99e-01	-0.047900	6.10e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	25	6.84e-01	0.047000	8.31e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	14	7.61e-01	0.046900	8.83e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	53	5.56e-01	0.046800	7.45e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	76	4.85e-01	-0.046300	6.89e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	7.20e-01	-0.046300	8.54e-01
RESOLUTION OF D LOOP STRUCTURES	30	6.63e-01	-0.045900	8.19e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	630	5.06e-02	0.045800	1.65e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	183	2.87e-01	0.045700	5.04e-01
PLASMA LIPOPROTEIN REMODELING	14	7.67e-01	0.045700	8.83e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	6.16e-01	0.045300	7.86e-01
NUCLEAR ENVELOPE BREAKDOWN	50	5.79e-01	-0.045300	7.67e-01
G PROTEIN ACTIVATION	22	7.15e-01	-0.045000	8.52e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	79	4.91e-01	0.044800	6.94e-01
SIGNALING BY CSF3 G CSF	29	6.77e-01	-0.044600	8.27e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	85	4.78e-01	0.044500	6.87e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	5.09e-01	-0.044400	7.04e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	7.99e-01	-0.044300	9.03e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	16	7.59e-01	0.044200	8.82e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	8.09e-01	0.044200	9.07e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	8.02e-01	-0.043600	9.04e-01
ERYTHROPOIETIN ACTIVATES RAS	13	7.85e-01	-0.043600	8.96e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	52	5.87e-01	-0.043600	7.70e-01
REPRODUCTION	79	5.05e-01	-0.043500	7.01e-01
CA2 PATHWAY	58	5.74e-01	0.042700	7.62e-01
O LINKED GLYCOSYLATION OF MUCINS	42	6.33e-01	-0.042700	7.98e-01
RAC3 GTPASE CYCLE	91	4.83e-01	0.042600	6.87e-01
CELLULAR HEXOSE TRANSPORT	11	8.07e-01	0.042500	9.07e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	12	7.99e-01	0.042400	9.03e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	19	7.49e-01	0.042400	8.74e-01
MAPK FAMILY SIGNALING CASCADES	290	2.15e-01	-0.042400	4.18e-01
ACYL CHAIN REMODELLING OF PE	17	7.67e-01	-0.041600	8.83e-01
MAP2K AND MAPK ACTIVATION	36	6.69e-01	0.041200	8.21e-01
RND1 GTPASE CYCLE	38	6.62e-01	0.041000	8.19e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	286	2.39e-01	-0.040500	4.49e-01
PREGNENOLONE BIOSYNTHESIS	12	8.09e-01	-0.040400	9.07e-01
PLASMA LIPOPROTEIN ASSEMBLY	12	8.09e-01	0.040300	9.07e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	7.81e-01	0.040200	8.95e-01
DNA DOUBLE STRAND BREAK RESPONSE	53	6.13e-01	0.040200	7.85e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	6.53e-01	-0.039700	8.13e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT	11	8.21e-01	0.039400	9.11e-01
GLYCOGEN METABOLISM	25	7.34e-01	0.039300	8.63e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	5.86e-01	-0.039100	7.69e-01
SIGNALLING TO RAS	20	7.62e-01	0.039100	8.83e-01
ADHERENS JUNCTIONS INTERACTIONS	30	7.12e-01	0.038900	8.50e-01
EGFR DOWNREGULATION	28	7.22e-01	-0.038900	8.54e-01
RAC2 GTPASE CYCLE	88	5.29e-01	0.038900	7.22e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	8.33e-01	-0.038500	9.17e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	45	6.55e-01	0.038500	8.15e-01
JOSEPHIN DOMAIN DUBS	11	8.25e-01	-0.038500	9.12e-01
SIGNALING BY FGFR1 IN DISEASE	33	7.04e-01	0.038300	8.44e-01
RHOD GTPASE CYCLE	51	6.39e-01	0.038000	8.02e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	7.26e-01	0.037600	8.58e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	5.49e-01	0.037400	7.40e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	181	3.87e-01	-0.037300	5.98e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	33	7.11e-01	-0.037300	8.50e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	86	5.51e-01	0.037200	7.40e-01
RETROGRADE NEUROTROPHIN SIGNALLING	14	8.10e-01	0.037200	9.07e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	7.35e-01	0.037000	8.64e-01
SIGNALING BY VEGF	104	5.15e-01	-0.037000	7.09e-01
AURKA ACTIVATION BY TPX2	72	5.88e-01	0.037000	7.70e-01
SODIUM CALCIUM EXCHANGERS	10	8.41e-01	-0.036700	9.20e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	47	6.65e-01	0.036500	8.19e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	23	7.62e-01	-0.036400	8.83e-01
INTERLEUKIN 27 SIGNALING	10	8.42e-01	0.036400	9.20e-01
SCAVENGING BY CLASS A RECEPTORS	15	8.09e-01	-0.036100	9.07e-01
TELOMERE EXTENSION BY TELOMERASE	22	7.70e-01	0.036100	8.85e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	8.37e-01	-0.035900	9.18e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	6.34e-01	0.035500	7.98e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	7.92e-01	-0.035000	9.01e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	5.90e-01	-0.034600	7.72e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	188	4.16e-01	0.034400	6.27e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	46	6.87e-01	-0.034400	8.32e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	8.45e-01	0.034100	9.21e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	8.45e-01	-0.034000	9.21e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	7.94e-01	-0.033800	9.02e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	8.16e-01	0.033700	9.08e-01
GLUCOSE METABOLISM	81	6.03e-01	-0.033500	7.80e-01
SIGNALING BY HEDGEHOG	142	5.00e-01	0.032800	7.00e-01
GABA RECEPTOR ACTIVATION	55	6.76e-01	-0.032600	8.26e-01
SIGNALING BY SCF KIT	41	7.20e-01	0.032300	8.54e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	7.90e-01	0.032100	9.00e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	103	5.73e-01	-0.032100	7.62e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	7.65e-01	0.032100	8.83e-01
SIGNALING BY ERBB2 IN CANCER	25	7.81e-01	-0.032100	8.95e-01
REPRESSION OF WNT TARGET GENES	14	8.36e-01	0.032000	9.18e-01
FANCONI ANEMIA PATHWAY	36	7.42e-01	-0.031700	8.67e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	8.13e-01	-0.031300	9.08e-01
SIGNALING BY HIPPO	20	8.11e-01	0.030900	9.07e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	7.82e-01	0.030800	8.95e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	42	7.31e-01	-0.030700	8.62e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	368	3.17e-01	-0.030400	5.31e-01
THE PHOTOTRANSDUCTION CASCADE	21	8.11e-01	0.030200	9.07e-01
SHC MEDIATED CASCADE FGFR3	13	8.51e-01	-0.030100	9.23e-01
SUMOYLATION	164	5.21e-01	-0.029100	7.14e-01
EPH EPHRIN SIGNALING	92	6.31e-01	-0.029000	7.96e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	8.46e-01	-0.028900	9.21e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	46	7.36e-01	-0.028800	8.64e-01
PI 3K CASCADE FGFR3	13	8.59e-01	0.028500	9.26e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	8.22e-01	-0.028400	9.11e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	286	4.11e-01	0.028300	6.23e-01
SIGNALING BY ERYTHROPOIETIN	24	8.14e-01	0.027700	9.08e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	30	7.97e-01	0.027100	9.03e-01
INSULIN PROCESSING	24	8.18e-01	-0.027100	9.10e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	8.77e-01	0.027000	9.41e-01
GPCR LIGAND BINDING	271	4.47e-01	0.026900	6.59e-01
AGGREPHAGY	35	7.91e-01	0.025900	9.01e-01
SURFACTANT METABOLISM	16	8.59e-01	-0.025700	9.26e-01
CELL JUNCTION ORGANIZATION	74	7.04e-01	-0.025600	8.44e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	7.72e-01	-0.025500	8.87e-01
REGULATION OF PTEN GENE TRANSCRIPTION	59	7.39e-01	-0.025100	8.66e-01
CIRCADIAN CLOCK	68	7.21e-01	0.025100	8.54e-01
RHOF GTPASE CYCLE	41	7.83e-01	-0.024800	8.96e-01
ZINC TRANSPORTERS	16	8.64e-01	0.024800	9.30e-01
LEISHMANIA INFECTION	199	5.51e-01	-0.024600	7.40e-01
METABOLISM OF VITAMINS AND COFACTORS	154	6.00e-01	-0.024500	7.80e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	8.24e-01	-0.024300	9.12e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	8.41e-01	0.024200	9.20e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	8.98e-01	-0.023500	9.51e-01
NUCLEAR IMPORT OF REV PROTEIN	32	8.19e-01	-0.023400	9.10e-01
SIGNALING BY ACTIVIN	12	8.89e-01	-0.023300	9.45e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	467	3.91e-01	-0.023200	6.00e-01
HDR THROUGH MMEJ ALT NHEJ	10	9.01e-01	-0.022700	9.51e-01
G ALPHA Q SIGNALLING EVENTS	157	6.25e-01	0.022600	7.92e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	8.84e-01	0.022400	9.44e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	8.14e-01	-0.022300	9.08e-01
RHOG GTPASE CYCLE	74	7.40e-01	0.022300	8.67e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	8.82e-01	-0.022200	9.43e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	91	7.16e-01	-0.022100	8.53e-01
VISUAL PHOTOTRANSDUCTION	61	7.67e-01	0.021900	8.83e-01
STRIATED MUSCLE CONTRACTION	28	8.41e-01	0.021900	9.20e-01
NUCLEOBASE CATABOLISM	31	8.34e-01	-0.021800	9.17e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	63	7.66e-01	-0.021700	8.83e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	8.65e-01	0.021500	9.30e-01
PEPTIDE LIGAND BINDING RECEPTORS	112	6.98e-01	0.021200	8.39e-01
G ALPHA I SIGNALLING EVENTS	205	6.05e-01	0.021000	7.82e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	93	7.27e-01	-0.020900	8.58e-01
PLATELET HOMEOSTASIS	78	7.53e-01	-0.020600	8.76e-01
GABA B RECEPTOR ACTIVATION	40	8.22e-01	0.020500	9.11e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	36	8.32e-01	-0.020500	9.16e-01
SIGNALING BY NOTCH	190	6.34e-01	-0.020100	7.98e-01
RECYCLING PATHWAY OF L1	40	8.28e-01	-0.019900	9.14e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	8.45e-01	-0.019600	9.21e-01
FRS MEDIATED FGFR4 SIGNALING	14	9.01e-01	-0.019200	9.51e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	8.57e-01	0.019000	9.26e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	8.50e-01	0.018800	9.23e-01
NUCLEOTIDE SALVAGE	21	8.82e-01	-0.018700	9.43e-01
SLC TRANSPORTER DISORDERS	77	7.82e-01	0.018300	8.95e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	8.87e-01	-0.017900	9.44e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	71	7.98e-01	-0.017500	9.03e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	9.14e-01	-0.017300	9.56e-01
CELL CELL COMMUNICATION	107	7.58e-01	0.017300	8.81e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	9.15e-01	0.017100	9.56e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	9.09e-01	0.017100	9.53e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	120	7.47e-01	0.017000	8.72e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	9.02e-01	-0.016800	9.51e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	8.56e-01	0.016400	9.26e-01
ACYL CHAIN REMODELLING OF PG	10	9.29e-01	-0.016300	9.64e-01
FRS MEDIATED FGFR3 SIGNALING	15	9.13e-01	0.016300	9.56e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	86	7.96e-01	0.016100	9.03e-01
REGULATION OF BETA CELL DEVELOPMENT	29	8.81e-01	0.016100	9.43e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	59	8.32e-01	-0.016000	9.16e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	9.04e-01	-0.015900	9.51e-01
DSCAM INTERACTIONS	11	9.29e-01	0.015500	9.64e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	45	8.58e-01	0.015400	9.26e-01
TRNA AMINOACYLATION	42	8.64e-01	-0.015300	9.30e-01
PI METABOLISM	79	8.15e-01	0.015200	9.08e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	9.04e-01	-0.015200	9.51e-01
REGULATION OF SIGNALING BY CBL	22	9.03e-01	0.015100	9.51e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	8.75e-01	-0.015000	9.39e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	8.85e-01	-0.015000	9.44e-01
SIGNALING BY FGFR4	33	8.82e-01	-0.014900	9.43e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	9.33e-01	-0.014700	9.66e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	8.26e-01	0.014300	9.12e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	14	9.26e-01	-0.014300	9.63e-01
SIGNALING BY FGFR3	35	8.84e-01	0.014200	9.44e-01
HEDGEHOG OFF STATE	107	8.02e-01	-0.014000	9.04e-01
GLYCOGEN STORAGE DISEASES	12	9.35e-01	-0.013700	9.67e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	9.09e-01	-0.013500	9.53e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	9.26e-01	-0.013400	9.63e-01
CELLULAR SENESCENCE	143	7.84e-01	-0.013300	8.96e-01
HS GAG BIOSYNTHESIS	30	9.02e-01	0.013000	9.51e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	9.42e-01	-0.012800	9.71e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	9.04e-01	0.012500	9.51e-01
DECTIN 2 FAMILY	10	9.47e-01	-0.012200	9.73e-01
HCMV EARLY EVENTS	81	8.50e-01	0.012100	9.23e-01
PI 3K CASCADE FGFR4	12	9.43e-01	-0.011900	9.72e-01
DEVELOPMENTAL BIOLOGY	832	5.77e-01	0.011400	7.65e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	7.95e-01	-0.011100	9.02e-01
GOLGI TO ER RETROGRADE TRANSPORT	119	8.39e-01	-0.010800	9.20e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	33	9.16e-01	0.010600	9.56e-01
HIV ELONGATION ARREST AND RECOVERY	32	9.18e-01	-0.010500	9.57e-01
SIGNALING BY PTK6	50	9.00e-01	-0.010300	9.51e-01
OXIDATIVE STRESS INDUCED SENESCENCE	79	8.86e-01	0.009300	9.44e-01
SIGNALING BY ERBB4	57	9.05e-01	-0.009170	9.51e-01
PI3K EVENTS IN ERBB2 SIGNALING	15	9.52e-01	-0.008960	9.75e-01
REGULATION OF TP53 ACTIVITY	154	8.53e-01	-0.008680	9.24e-01
REGULATION OF FZD BY UBIQUITINATION	19	9.48e-01	0.008580	9.73e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	9.15e-01	0.008520	9.56e-01
GLYCOLYSIS	67	9.04e-01	-0.008510	9.51e-01
SIGNALING BY WNT IN CANCER	31	9.36e-01	0.008380	9.67e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	58	9.13e-01	-0.008340	9.56e-01
CARNITINE METABOLISM	14	9.57e-01	-0.008240	9.76e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	9.48e-01	0.008000	9.73e-01
GENE SILENCING BY RNA	83	9.02e-01	0.007790	9.51e-01
FCERI MEDIATED CA 2 MOBILIZATION	26	9.46e-01	-0.007680	9.73e-01
CGMP EFFECTS	15	9.60e-01	0.007490	9.77e-01
EPHRIN SIGNALING	19	9.55e-01	0.007460	9.75e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	9.49e-01	-0.006930	9.73e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	51	9.32e-01	-0.006890	9.66e-01
METABOLISM OF CARBOHYDRATES	261	8.51e-01	0.006770	9.23e-01
FORMATION OF THE CORNIFIED ENVELOPE	27	9.54e-01	0.006470	9.75e-01
KERATINIZATION	27	9.54e-01	0.006470	9.75e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	9.63e-01	-0.005960	9.79e-01
UNFOLDED PROTEIN RESPONSE UPR	85	9.26e-01	-0.005850	9.63e-01
NUCLEAR SIGNALING BY ERBB4	31	9.59e-01	0.005370	9.77e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	39	9.54e-01	0.005340	9.75e-01
INTEGRIN CELL SURFACE INTERACTIONS	74	9.38e-01	-0.005190	9.69e-01
PI3K AKT SIGNALING IN CANCER	90	9.33e-01	-0.005150	9.66e-01
ERBB2 REGULATES CELL MOTILITY	14	9.74e-01	-0.004940	9.88e-01
TRANSPORT OF SMALL MOLECULES	590	8.70e-01	-0.003960	9.35e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	9.61e-01	-0.003650	9.78e-01
MITOTIC TELOPHASE CYTOKINESIS	13	9.83e-01	0.003380	9.92e-01
SIGNALING BY PDGFR IN DISEASE	20	9.80e-01	-0.003280	9.91e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	9.83e-01	0.003200	9.92e-01
INTRA GOLGI TRAFFIC	43	9.72e-01	-0.003120	9.87e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	35	9.76e-01	0.002970	9.88e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	9.80e-01	-0.002550	9.91e-01
LDL CLEARANCE	16	9.88e-01	-0.002220	9.93e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	9.91e-01	-0.002030	9.95e-01
OPIOID SIGNALLING	86	9.74e-01	0.002020	9.88e-01
HEMOSTASIS	475	9.45e-01	0.001850	9.73e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	9.85e-01	0.001810	9.92e-01
SYNTHESIS OF PC	27	9.88e-01	-0.001680	9.93e-01
POTENTIAL THERAPEUTICS FOR SARS	78	9.85e-01	-0.001240	9.92e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	9.95e-01	-0.001030	9.96e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	9.96e-01	-0.001020	9.96e-01
NOD1 2 SIGNALING PATHWAY	35	9.94e-01	0.000765	9.96e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	95	9.90e-01	0.000742	9.94e-01
NERVOUS SYSTEM DEVELOPMENT	554	9.82e-01	0.000549	9.92e-01
DISEASES OF IMMUNE SYSTEM	27	9.96e-01	-0.000495	9.96e-01

---

Detailed Gene set reports

ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN

ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN

	299
set	ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
setSize	10
pANOVA	0.000141
s.dist	-0.695
p.adjustANOVA	0.00154

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Aqp1	-8402
Hbb-bt	-8023
Cyb5r4	-7594
Car4	-6819
Hba-a1	-6349
Cyb5r2	-6138
Cyb5r1	-5444
Hba-a2	-5283
Car2	-4736
Cyb5rl	1429

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Aqp1	-8402
Hbb-bt	-8023
Cyb5r4	-7594
Car4	-6819
Hba-a1	-6349
Cyb5r2	-6138
Cyb5r1	-5444
Hba-a2	-5283
Car2	-4736
Cyb5rl	1429

---

ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY

	35
set	ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize	10
pANOVA	0.000195
s.dist	0.68
p.adjustANOVA	0.00203

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy6	8807
Adcy4	8795
Adcy5	7460
Adcy8	7205
Adcy2	6106
Adcy9	5535
Adcy3	5523
Adcy7	5402
Gnal	4616
Adcy1	3287

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy6	8807
Adcy4	8795
Adcy5	7460
Adcy8	7205
Adcy2	6106
Adcy9	5535
Adcy3	5523
Adcy7	5402
Gnal	4616
Adcy1	3287

---

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

	817
set	REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize	17
pANOVA	6.32e-05
s.dist	0.56
p.adjustANOVA	0.000809

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ago3	8738
Tnrc6b	8726
Ago2	8313
Tnrc6a	8107
Ptpn11	7387
Mov10	7384
Ago1	6862
Pml	6835
Cdk6	6627
Ago4	5781
Runx1	5573
Src	5451
Tnrc6c	5157
Ccnd2	3372
Ccnd3	2218
Cbfb	-2842
Ccnd1	-4876

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ago3	8738
Tnrc6b	8726
Ago2	8313
Tnrc6a	8107
Ptpn11	7387
Mov10	7384
Ago1	6862
Pml	6835
Cdk6	6627
Ago4	5781
Runx1	5573
Src	5451
Tnrc6c	5157
Ccnd2	3372
Ccnd3	2218
Cbfb	-2842
Ccnd1	-4876

---

ENDOSOMAL VACUOLAR PATHWAY

ENDOSOMAL VACUOLAR PATHWAY

	283
set	ENDOSOMAL VACUOLAR PATHWAY
setSize	10
pANOVA	0.00388
s.dist	-0.527
p.adjustANOVA	0.0256

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2-T23	-7996
B2m	-7326
H2-M3	-6895
Ctsl	-6233
Ctss	-5908
H2-D1	-5834
H2-Q7	-4557
H2-Q2	-3151
H2-Q10	705
Lnpep	4487

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2-T23	-7996
B2m	-7326
H2-M3	-6895
Ctsl	-6233
Ctss	-5908
H2-D1	-5834
H2-Q7	-4557
H2-Q2	-3151
H2-Q10	705
Lnpep	4487

---

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

	1106
set	TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize	11
pANOVA	0.00283
s.dist	-0.52
p.adjustANOVA	0.0197

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Tlr3	-7487
Hsp90b1	-6977
Lgmn	-6719
Ctsl	-6233
Ctss	-5908
Ctsb	-5445
Tlr7	-3907
Cnpy3	-3425
Ctsk	-2446
Unc93b1	-991
Tlr9	3276

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Tlr3	-7487
Hsp90b1	-6977
Lgmn	-6719
Ctsl	-6233
Ctss	-5908
Ctsb	-5445
Tlr7	-3907
Cnpy3	-3425
Ctsk	-2446
Unc93b1	-991
Tlr9	3276

---

INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS

	461
set	INTERACTION BETWEEN L1 AND ANKYRINS
setSize	27
pANOVA	4.35e-06
s.dist	0.511
p.adjustANOVA	8.55e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sptbn4	9031
Nfasc	8962
Kcnq2	8536
Sptbn5	8498
Ank2	8454
Scn8a	8237
Ank3	7702
Sptb	6944
Sptan1	6803
Sptbn2	6783
Ank1	6709
Sptbn1	6657
L1cam	6559
Scn5a	6452
Scn2b	6181
Scn9a	5418
Scn7a	3987
Nrcam	3474
Scn4b	3458
Scn3a	3400

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sptbn4	9031
Nfasc	8962
Kcnq2	8536
Sptbn5	8498
Ank2	8454
Scn8a	8237
Ank3	7702
Sptb	6944
Sptan1	6803
Sptbn2	6783
Ank1	6709
Sptbn1	6657
L1cam	6559
Scn5a	6452
Scn2b	6181
Scn9a	5418
Scn7a	3987
Nrcam	3474
Scn4b	3458
Scn3a	3400
Scn2a	2477
Scn3b	2230
Kcnq3	2109
Scn1a	1587
Scn1b	-2545
Actb	-2632
Actg1	-6189

---

RETINOID CYCLE DISEASE EVENTS

RETINOID CYCLE DISEASE EVENTS

	843
set	RETINOID CYCLE DISEASE EVENTS
setSize	10
pANOVA	0.00739
s.dist	-0.489
p.adjustANOVA	0.0422

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Stra6	-8225
Abca4	-8163
Ttr	-7408
Rdh5	-6237
Napepld	-5214
Rdh12	-5021
Rbp1	-3616
Lrat	787
Rlbp1	1485
Rbp4	2232

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Stra6	-8225
Abca4	-8163
Ttr	-7408
Rdh5	-6237
Napepld	-5214
Rdh12	-5021
Rbp1	-3616
Lrat	787
Rlbp1	1485
Rbp4	2232

---

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

	1035
set	SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize	29
pANOVA	6.4e-06
s.dist	-0.484
p.adjustANOVA	0.000113

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8221
Ube2q2	-8178
Uchl3	-8038
Ube2e1	-7973
Ube2b	-7942
Ube2a	-7921
Ube2l3	-7831
Ube2k	-7805
Ube2d2a	-7701
Ube2r2	-5535
Ube2s	-4651
Otulin	-4523
Cdc34	-4472
Ubb	-4221
Rps27a	-4124
Ube2t	-3528
Uba6	-3395

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8221
Ube2q2	-8178
Uchl3	-8038
Ube2e1	-7973
Ube2b	-7942
Ube2a	-7921
Ube2l3	-7831
Ube2k	-7805
Ube2d2a	-7701
Ube2r2	-5535
Ube2s	-4651
Otulin	-4523
Cdc34	-4472
Ubb	-4221
Rps27a	-4124
Ube2t	-3528
Uba6	-3395
Usp9x	-2427
Ube2z	-1185
Usp5	2235
Ube2h	2263
Ube2g2	2747
Usp7	2984
Ubc	3480
Uba52	3691
Uba1	4503

---

LGI ADAM INTERACTIONS

LGI ADAM INTERACTIONS

	518
set	LGI ADAM INTERACTIONS
setSize	14
pANOVA	0.00277
s.dist	0.462
p.adjustANOVA	0.0195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adam22	8016
Cacng8	7874
Stx1b	7703
Adam11	7573
Lgi2	7207
Stx1a	6798
Cacng4	6480
Dlg4	6247
Cacng3	5233
Lgi3	4265
Cacng2	3168
Adam23	1641
Lgi4	-4756
Lgi1	-6342

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adam22	8016
Cacng8	7874
Stx1b	7703
Adam11	7573
Lgi2	7207
Stx1a	6798
Cacng4	6480
Dlg4	6247
Cacng3	5233
Lgi3	4265
Cacng2	3168
Adam23	1641
Lgi4	-4756
Lgi1	-6342

---

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

	1176
set	YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
setSize	11
pANOVA	0.00997
s.dist	0.449
p.adjustANOVA	0.0537

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Hipk2	8826
Tead2	8492
Tead3	8233
Hipk1	7691
Tead1	7226
Yap1	6637
Runx2	6579
Tead4	1791
Ccn2	1407
Wwtr1	-2220
Kat2b	-7901

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Hipk2	8826
Tead2	8492
Tead3	8233
Hipk1	7691
Tead1	7226
Yap1	6637
Runx2	6579
Tead4	1791
Ccn2	1407
Wwtr1	-2220
Kat2b	-7901

---

CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT

CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT

	158
set	CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
setSize	20
pANOVA	0.000516
s.dist	-0.448
p.adjustANOVA	0.00482

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atad1	-8342
Pex3	-8048
Slc25a17	-7800
Acbd5	-7619
Pex13	-7516
Abcd2	-7513
Pex2	-7320
Gdap1	-6703
Pex11b	-6362
Abcd3	-3434
Aldh3a2	-3312
Pex19	-2655
Pex14	-2364
Fis1	-2131
Pxmp4	-1092
Pxmp2	-1007
Pex12	172
Pex16	962
Pex26	2534
Abcd1	7955

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atad1	-8342
Pex3	-8048
Slc25a17	-7800
Acbd5	-7619
Pex13	-7516
Abcd2	-7513
Pex2	-7320
Gdap1	-6703
Pex11b	-6362
Abcd3	-3434
Aldh3a2	-3312
Pex19	-2655
Pex14	-2364
Fis1	-2131
Pxmp4	-1092
Pxmp2	-1007
Pex12	172
Pex16	962
Pex26	2534
Abcd1	7955

---

P75NTR REGULATES AXONOGENESIS

P75NTR REGULATES AXONOGENESIS

	679
set	P75NTR REGULATES AXONOGENESIS
setSize	10
pANOVA	0.0152
s.dist	-0.443
p.adjustANOVA	0.0735

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Omg	-7628
Rhoa	-7527
Mcf2	-7459
Rtn4	-6580
Rtn4r	-6460
Ngf	-5442
Mag	-1769
Lingo1	-243
Arhgdia	2865
Ngfr	4875

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Omg	-7628
Rhoa	-7527
Mcf2	-7459
Rtn4	-6580
Rtn4r	-6460
Ngf	-5442
Mag	-1769
Lingo1	-243
Arhgdia	2865
Ngfr	4875

---

THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION

THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION

	1069
set	THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION
setSize	15
pANOVA	0.00318
s.dist	-0.44
p.adjustANOVA	0.0214

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Stra6	-8225
Abca4	-8163
Ttr	-7408
Rdh11	-6941
Cyp4v3	-6543
Rdh5	-6237
Napepld	-5214
Rdh12	-5021
Rbp1	-3616
Rdh10	-2641
Rdh1	-349
Lrat	787
Rlbp1	1485
Rbp4	2232
Myo7a	3260

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Stra6	-8225
Abca4	-8163
Ttr	-7408
Rdh11	-6941
Cyp4v3	-6543
Rdh5	-6237
Napepld	-5214
Rdh12	-5021
Rbp1	-3616
Rdh10	-2641
Rdh1	-349
Lrat	787
Rlbp1	1485
Rbp4	2232
Myo7a	3260

---

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

	736
set	PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
setSize	11
pANOVA	0.0116
s.dist	0.44
p.adjustANOVA	0.0605

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cacna1b	8238
Cacna1e	7552
Cacna1a	6707
Cacnb3	6681
Cacng4	6480
Cacnb1	6153
Cacna2d2	5810
Cacng2	3168
Cacnb2	927
Cacna2d3	424
Cacnb4	-6238

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cacna1b	8238
Cacna1e	7552
Cacna1a	6707
Cacnb3	6681
Cacng4	6480
Cacnb1	6153
Cacna2d2	5810
Cacng2	3168
Cacnb2	927
Cacna2d3	424
Cacnb4	-6238

---

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

	216
set	DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
setSize	20
pANOVA	0.00113
s.dist	0.421
p.adjustANOVA	0.00922

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cspg4	8443
Ncan	8140
Gpc2	8054
Sdc4	7950
Agrn	7772
Bcan	7329
Gpc4	6870
Gpc3	5369
Sdc3	4437
Hspg2	4411
Gpc1	4370
Bgn	4058
Vcan	4052
B4galt7	3013
Gpc6	1263
Dcn	238
Sdc1	-59
Gpc5	-316
Cspg5	-584
Sdc2	-4724

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cspg4	8443
Ncan	8140
Gpc2	8054
Sdc4	7950
Agrn	7772
Bcan	7329
Gpc4	6870
Gpc3	5369
Sdc3	4437
Hspg2	4411
Gpc1	4370
Bgn	4058
Vcan	4052
B4galt7	3013
Gpc6	1263
Dcn	238
Sdc1	-59
Gpc5	-316
Cspg5	-584
Sdc2	-4724

---

CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY

	124
set	CD28 DEPENDENT VAV1 PATHWAY
setSize	11
pANOVA	0.0175
s.dist	-0.414
p.adjustANOVA	0.0817

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cdc42	-8020
Rac1	-7231
Pak1	-7056
Cd86	-6182
Pak2	-4849
Pak3	-3900
Vav1	-3338
Grb2	-3243
Fyn	-777
Lck	2493
Cd80	6041

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cdc42	-8020
Rac1	-7231
Pak1	-7056
Cd86	-6182
Pak2	-4849
Pak3	-3900
Vav1	-3338
Grb2	-3243
Fyn	-777
Lck	2493
Cd80	6041

---

RORA ACTIVATES GENE EXPRESSION

RORA ACTIVATES GENE EXPRESSION

	893
set	RORA ACTIVATES GENE EXPRESSION
setSize	18
pANOVA	0.00258
s.dist	0.41
p.adjustANOVA	0.0186

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Crebbp	8604
Rxra	8088
Srebf1	7993
Chd9	7486
Med1	6809
Helz2	6449
Carm1	6318
Ncoa6	5920
Ep300	4550
Ncoa1	4445
Ppara	4345
Cpt1a	2881
Ncoa2	2549
Smarcd3	1704
Tbl1x	329
Tgs1	-1318
Rora	-2366
Tbl1xr1	-4334

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Crebbp	8604
Rxra	8088
Srebf1	7993
Chd9	7486
Med1	6809
Helz2	6449
Carm1	6318
Ncoa6	5920
Ep300	4550
Ncoa1	4445
Ppara	4345
Cpt1a	2881
Ncoa2	2549
Smarcd3	1704
Tbl1x	329
Tgs1	-1318
Rora	-2366
Tbl1xr1	-4334

---

MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION

	571
set	MITOCHONDRIAL TRANSLATION
setSize	93
pANOVA	1.33e-11
s.dist	-0.406
p.adjustANOVA	2.61e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Mrpl1	-8372
Mrpl50	-8312
Mrpl16	-8170
Mrps30	-8052
Mrps31	-7987
Mrpl10	-7856
Mrpl40	-7781
Mrps22	-7548
Mrpl3	-7511
Mrpl32	-7226
Mrps23	-7168
Mrpl47	-7048
Mrpl22	-6888
Mrps2	-6767
Mrps14	-6370
Mrpl17	-6224
Mrpl15	-5891
Mrpl13	-5815
Mrpl34	-5625
Ptcd3	-5530

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Mrpl1	-8372
Mrpl50	-8312
Mrpl16	-8170
Mrps30	-8052
Mrps31	-7987
Mrpl10	-7856
Mrpl40	-7781
Mrps22	-7548
Mrpl3	-7511
Mrpl32	-7226
Mrps23	-7168
Mrpl47	-7048
Mrpl22	-6888
Mrps2	-6767
Mrps14	-6370
Mrpl17	-6224
Mrpl15	-5891
Mrpl13	-5815
Mrpl34	-5625
Ptcd3	-5530
Mrpl30	-5476
Mrpl49	-5416
Mrpl27	-5405
Mrpl57	-5306
Chchd1	-5288
Mrpl42	-5157
Mrps18c	-5113
Mrpl48	-5075
Mrpl33	-5053
Mrpl39	-5003
Mrpl11	-4959
Mrpl9	-4954
Mtif2	-4873
Mrpl46	-4657
Mrps36	-4593
Mrps17	-4525
Oxa1l	-4513
Mrrf	-4421
Tsfm	-4308
Mrps33	-4133
Mrps27	-3957
Mrps18b	-3859
Mrpl44	-3828
Mtif3	-3813
Mrpl18	-3701
Gadd45gip1	-3617
Mrpl54	-3558
Mrps26	-3547
Mrps10	-3545
Mrps28	-3440
Mrpl28	-3315
Mrpl43	-3304
Mrps18a	-3226
Mrpl12	-3216
Mrpl20	-3205
Mrpl19	-3155
Mrps16	-3110
Mrpl51	-3044
Mrps25	-3036
Mrpl21	-2960
Mrps15	-2949
Mrpl52	-2883
Mrpl35	-2863
Mrps12	-2693
Mrpl2	-2584
Mrps7	-2517
Mrps9	-2491
Mrps24	-2225
Mrpl23	-2048
Mrpl41	-1998
Mrpl53	-1939
Mrpl55	-1656
Mrpl58	-1627
Mrpl24	-1572
Mrpl36	-1429
Mrps21	-804
Mrpl14	-667
Mrps5	-163
Mrps11	-100
Mrps34	384
Aurkaip1	385
Mrpl37	403
Mrps6	685
Mrps35	1577
Mrpl38	2985
Eral1	3185
Gfm1	3942
Tufm	4206
Mtfmt	5091
Dap3	5540
Mtrf1l	5671
Mrpl4	5960
Gfm2	7012

---

RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY

	778
set	RECEPTOR MEDIATED MITOPHAGY
setSize	11
pANOVA	0.02
s.dist	-0.405
p.adjustANOVA	0.0888

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atg12	-8205
Fundc1	-8009
Atg5	-7837
Pgam5	-6808
Csnk2a2	-5327
Map1lc3b	-4660
Csnk2b	-4346
Csnk2a1	-2182
Map1lc3a	-854
Src	5451
Ulk1	7554

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atg12	-8205
Fundc1	-8009
Atg5	-7837
Pgam5	-6808
Csnk2a2	-5327
Map1lc3b	-4660
Csnk2b	-4346
Csnk2a1	-2182
Map1lc3a	-854
Src	5451
Ulk1	7554

---

CRISTAE FORMATION

CRISTAE FORMATION

	187
set	CRISTAE FORMATION
setSize	31
pANOVA	0.000104
s.dist	-0.403
p.adjustANOVA	0.00123

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Apoo	-8139
Atp5c1	-8076
Mtx2	-8034
Atp5pb	-7499
Dmac2l	-7278
Mtx1	-5733
Apool	-5527
mt-Atp6	-5071
Atp5b	-4886
Atp5h	-4812
Atp5o	-4698
Atp5l	-4684
Chchd3	-4637
Atp5a1	-4502
Atp5g3	-4458
Immt	-3534
Tmem11	-3471
Hspa9	-3340
Chchd6	-3296
Micos10	-3146

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Apoo	-8139
Atp5c1	-8076
Mtx2	-8034
Atp5pb	-7499
Dmac2l	-7278
Mtx1	-5733
Apool	-5527
mt-Atp6	-5071
Atp5b	-4886
Atp5h	-4812
Atp5o	-4698
Atp5l	-4684
Chchd3	-4637
Atp5a1	-4502
Atp5g3	-4458
Immt	-3534
Tmem11	-3471
Hspa9	-3340
Chchd6	-3296
Micos10	-3146
Atp5g2	-3059
Micos13	-2576
Atp5j2	-1520
Atp5e	-1120
Atp5j	-1104
Atp5d	320
Samm50	900
Atp5g1	1349
Atp5k	2050
Dnajc11	3708
mt-Atp8	7353

---

BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM

	103
set	BRANCHED CHAIN AMINO ACID CATABOLISM
setSize	21
pANOVA	0.00153
s.dist	-0.399
p.adjustANOVA	0.012

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Dld	-8190
Acat1	-7989
Hibadh	-7679
Acad8	-7620
Mccc2	-6938
Bckdhb	-6748
Echs1	-6634
Aldh6a1	-6447
Hibch	-5886
Acadsb	-5537
Ppm1k	-5382
Auh	-5364
Dbt	-4509
Hsd17b10	-4464
Bckdk	-4353
Bckdha	779
Slc25a44	3735
Bcat1	5066
Bcat2	5464
Ivd	5519

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Dld	-8190
Acat1	-7989
Hibadh	-7679
Acad8	-7620
Mccc2	-6938
Bckdhb	-6748
Echs1	-6634
Aldh6a1	-6447
Hibch	-5886
Acadsb	-5537
Ppm1k	-5382
Auh	-5364
Dbt	-4509
Hsd17b10	-4464
Bckdk	-4353
Bckdha	779
Slc25a44	3735
Bcat1	5066
Bcat2	5464
Ivd	5519
Mccc1	6999

---

PENTOSE PHOSPHATE PATHWAY

PENTOSE PHOSPHATE PATHWAY

	685
set	PENTOSE PHOSPHATE PATHWAY
setSize	13
pANOVA	0.013
s.dist	-0.398
p.adjustANOVA	0.0652

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Prps2	-8270
Rpe	-7876
Rbks	-7612
Taldo1	-6865
Pgm2	-6624
Prps1	-4907
Shpk	-2539
G6pdx	-1632
Tkt	-961
Pgls	-216
Dera	1612
Pgd	1849
Rpia	3207

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Prps2	-8270
Rpe	-7876
Rbks	-7612
Taldo1	-6865
Pgm2	-6624
Prps1	-4907
Shpk	-2539
G6pdx	-1632
Tkt	-961
Pgls	-216
Dera	1612
Pgd	1849
Rpia	3207

---

METABOLISM OF POLYAMINES

METABOLISM OF POLYAMINES

	552
set	METABOLISM OF POLYAMINES
setSize	58
pANOVA	1.59e-07
s.dist	-0.398
p.adjustANOVA	6.05e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Nqo1	-7892
Psmd12	-7878
Psmb9	-7862
Sms	-7762
Amd1	-7587
Psma6	-7580
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Azin1	-6577
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Paox	-5468
Psmb7	-5401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Nqo1	-7892
Psmd12	-7878
Psmb9	-7862
Sms	-7762
Amd1	-7587
Psma6	-7580
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Azin1	-6577
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Paox	-5468
Psmb7	-5401
Psmc2	-5064
Psma4	-4815
Psmd5	-4603
Psmb3	-4590
Psma3	-4517
Srm	-4333
Odc1	-4329
Sat1	-4125
Psme2	-4121
Psma7	-3980
Oaz2	-3954
Psma8	-3884
Psmd9	-3332
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Oaz1	-1519
Psmb4	-1483
Azin2	-406
Psmd11	-127
Psmc4	123
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Agmat	1868
Psmd4	2248
Psmd3	2918
Psmd2	3350
Psme4	3590
Oaz3	6299
Smox	8841

---

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

	179
set	COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize	26
pANOVA	0.000446
s.dist	-0.398
p.adjustANOVA	0.00428

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Vbp1	-8262
Cct6a	-7953
Tuba1c	-7927
Cct4	-7432
Pfdn4	-7390
Tcp1	-7383
Cct2	-6966
Cct5	-5869
Cct7	-5850
Cct8	-5469
Tuba8	-4989
Tuba1b	-4438
Pfdn1	-4319
Tuba4a	-3800
Cct3	-2878
Tubb4b	-2642
Actb	-2632
Pfdn5	-2071
Tuba1a	-1728
Pfdn6	-1533

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Vbp1	-8262
Cct6a	-7953
Tuba1c	-7927
Cct4	-7432
Pfdn4	-7390
Tcp1	-7383
Cct2	-6966
Cct5	-5869
Cct7	-5850
Cct8	-5469
Tuba8	-4989
Tuba1b	-4438
Pfdn1	-4319
Tuba4a	-3800
Cct3	-2878
Tubb4b	-2642
Actb	-2632
Pfdn5	-2071
Tuba1a	-1728
Pfdn6	-1533
Tubb3	483
Tubb2a	880
Pfdn2	4037
Tubb2b	4298
Tubb4a	4734
Tubb6	5550

---

NEGATIVE REGULATION OF NOTCH4 SIGNALING

NEGATIVE REGULATION OF NOTCH4 SIGNALING

	611
set	NEGATIVE REGULATION OF NOTCH4 SIGNALING
setSize	54
pANOVA	4.32e-07
s.dist	-0.398
p.adjustANOVA	1.34e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Skp1	-7764
Psma6	-7580
Cul1	-7450
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Ywhaz	-6972
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064
Psma4	-4815

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Skp1	-7764
Psma6	-7580
Cul1	-7450
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Ywhaz	-6972
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064
Psma4	-4815
Rbx1	-4727
Psmd5	-4603
Psmb3	-4590
Psma3	-4517
Fbxw7	-4341
Ubb	-4221
Rps27a	-4124
Psme2	-4121
Psma7	-3980
Psmd9	-3332
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Tacc3	-1588
Psmc5	-1555
Psmb4	-1483
Psmd11	-127
Psmc4	123
Akt1	440
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Ubc	3480
Uba52	3691
Notch4	8969

---

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

	340
set	FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize	19
pANOVA	0.00278
s.dist	-0.396
p.adjustANOVA	0.0195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cct6a	-7953
Tuba1c	-7927
Cct4	-7432
Tcp1	-7383
Cct2	-6966
Cct5	-5869
Cct7	-5850
Cct8	-5469
Tuba8	-4989
Tuba1b	-4438
Tuba4a	-3800
Cct3	-2878
Tubb4b	-2642
Tuba1a	-1728
Tubb3	483
Tubb2a	880
Tubb2b	4298
Tubb4a	4734
Tubb6	5550

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cct6a	-7953
Tuba1c	-7927
Cct4	-7432
Tcp1	-7383
Cct2	-6966
Cct5	-5869
Cct7	-5850
Cct8	-5469
Tuba8	-4989
Tuba1b	-4438
Tuba4a	-3800
Cct3	-2878
Tubb4b	-2642
Tuba1a	-1728
Tubb3	483
Tubb2a	880
Tubb2b	4298
Tubb4a	4734
Tubb6	5550

---

ASSEMBLY OF THE PRE REPLICATIVE COMPLEX

ASSEMBLY OF THE PRE REPLICATIVE COMPLEX

	77
set	ASSEMBLY OF THE PRE REPLICATIVE COMPLEX
setSize	65
pANOVA	3.29e-08
s.dist	-0.396
p.adjustANOVA	1.69e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Orc5	-7806
Orc6	-7773
Psma6	-7580
Orc4	-7371
Psma2	-7177
Psmd6	-7172
Mcm3	-7063
Psmf1	-7032
E2f2	-6976
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5506
Psmd10	-5497

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Orc5	-7806
Orc6	-7773
Psma6	-7580
Orc4	-7371
Psma2	-7177
Psmd6	-7172
Mcm3	-7063
Psmf1	-7032
E2f2	-6976
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064
Psma4	-4815
Psmd5	-4603
Psmb3	-4590
Psma3	-4517
Ubb	-4221
Rps27a	-4124
Psme2	-4121
E2f3	-4111
Mcm4	-4077
Psma7	-3980
Psma8	-3884
Mcm5	-3618
Psmd9	-3332
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Mcm8	-2252
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Psmb4	-1483
Orc3	-1296
Mcm6	-1096
Cdt1	-1095
Gmnn	-591
Psmd11	-127
Mcm2	-30
Psmc4	123
Mcm7	442
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Ubc	3480
Psme4	3590
Uba52	3691
E2f1	3868

---

SIGNALING BY LEPTIN

SIGNALING BY LEPTIN

	967
set	SIGNALING BY LEPTIN
setSize	10
pANOVA	0.0301
s.dist	0.396
p.adjustANOVA	0.118

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sh2b1	8845
Stat3	7899
Ptpn11	7387
Stat5b	5594
Stat5a	4171
Irs1	3445
Irs2	3242
Socs3	2059
Jak2	-2188
Lepr	-2548

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sh2b1	8845
Stat3	7899
Ptpn11	7387
Stat5b	5594
Stat5a	4171
Irs1	3445
Irs2	3242
Socs3	2059
Jak2	-2188
Lepr	-2548

---

TIGHT JUNCTION INTERACTIONS

TIGHT JUNCTION INTERACTIONS

	1081
set	TIGHT JUNCTION INTERACTIONS
setSize	17
pANOVA	0.00474
s.dist	-0.396
p.adjustANOVA	0.0304

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cldn2	-8385
Cldn1	-7898
Cldn10	-7694
Crb3	-7193
Pals1	-6579
Cldn23	-4946
Pard6a	-4738
F11r	-4695
Cldn14	-3402
Cldn12	-2380
Cldn11	-2050
Pard6g	-1513
Prkci	-1137
Pard6b	-920
Cldn5	566
Patj	2870
Pard3	7067

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cldn2	-8385
Cldn1	-7898
Cldn10	-7694
Crb3	-7193
Pals1	-6579
Cldn23	-4946
Pard6a	-4738
F11r	-4695
Cldn14	-3402
Cldn12	-2380
Cldn11	-2050
Pard6g	-1513
Prkci	-1137
Pard6b	-920
Cldn5	566
Patj	2870
Pard3	7067

---

UNWINDING OF DNA

UNWINDING OF DNA

	1160
set	UNWINDING OF DNA
setSize	12
pANOVA	0.0186
s.dist	-0.392
p.adjustANOVA	0.0847

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gins4	-7425
Mcm3	-7063
Gins1	-6211
Mcm4	-4077
Mcm5	-3618
Cdc45	-3505
Mcm8	-2252
Gins2	-1938
Mcm6	-1096
Gins3	-341
Mcm2	-30
Mcm7	442

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gins4	-7425
Mcm3	-7063
Gins1	-6211
Mcm4	-4077
Mcm5	-3618
Cdc45	-3505
Mcm8	-2252
Gins2	-1938
Mcm6	-1096
Gins3	-341
Mcm2	-30
Mcm7	442

---

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

	189
set	CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize	47
pANOVA	3.49e-06
s.dist	-0.391
p.adjustANOVA	7.49e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Psma6	-7580
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Fcgr1	-5383
Psmc2	-5064
Psma4	-4815
Psmd5	-4603
Psmb3	-4590

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Psma6	-7580
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Fcgr1	-5383
Psmc2	-5064
Psma4	-4815
Psmd5	-4603
Psmb3	-4590
Psma3	-4517
Psme2	-4121
Psma7	-3980
Psma8	-3884
Psmd9	-3332
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Psmb10	-2155
Mrc1	-1887
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Psmb4	-1483
Psmd11	-127
Psmc4	123
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Psme4	3590
Mrc2	7439

---

RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT

	836
set	RESPIRATORY ELECTRON TRANSPORT
setSize	102
pANOVA	1.02e-11
s.dist	-0.39
p.adjustANOVA	2.41e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sco2	-8357
Ndufaf1	-7780
Ndufaf4	-7557
Coq10b	-7517
Ndufv2	-7287
Nubpl	-7180
Etfdh	-7137
mt-Nd2	-7057
Uqcrc2	-7010
Ndufc2	-6893
Cycs	-6845
Etfa	-6716
mt-Nd6	-6545
Uqcrfs1	-6297
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
Sdhb	-6076
mt-Nd1	-5998
Ndufaf2	-5957

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sco2	-8357
Ndufaf1	-7780
Ndufaf4	-7557
Coq10b	-7517
Ndufv2	-7287
Nubpl	-7180
Etfdh	-7137
mt-Nd2	-7057
Uqcrc2	-7010
Ndufc2	-6893
Cycs	-6845
Etfa	-6716
mt-Nd6	-6545
Uqcrfs1	-6297
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
Sdhb	-6076
mt-Nd1	-5998
Ndufaf2	-5957
mt-Nd5	-5921
Ndufb5	-5763
Ndufs1	-5653
mt-Co1	-5647
Sdhd	-5575
mt-Co2	-5539
mt-Cytb	-5502
Sco1	-5156
mt-Co3	-5129
Sdhc	-5048
Ndufb11	-4979
Cox7a2l	-4713
Ndufs8	-4550
Uqcrh	-4429
Ndufs3	-4358
Surf1	-4315
Ndufa10	-4299
Cox5a	-4288
Ndufab1	-4269
Ndufb4	-4254
Ndufb9	-4240
Ndufb3	-4238
Cyc1	-4095
Etfb	-4069
Ndufb8	-3922
Cox6b1	-3860
Ndufa4	-3836
Uqcrb	-3736
Ndufb6	-3352
Tmem126b	-3342
Cox7b	-3317
Cox16	-3255
Ndufa11	-3129
Ndufb10	-2954
Cox7c	-2945
Ecsit	-2884
Ndufa9	-2857
Ndufs5	-2848
Cox6a1	-2782
Cox14	-2704
Coq10a	-2700
Ndufa7	-2650
Ndufs2	-2591
Cox4i1	-2505
Ndufb2	-2480
Ndufc1	-2357
Cox11	-2219
Ndufa8	-1983
Uqcrc1	-1869
Cox20	-1722
Ndufv1	-1558
Ndufa2	-1531
Cox6c	-1398
Ndufa5	-1343
Uqcrq	-1293
Cox8a	-1268
Ndufaf3	-1245
Ndufb1	-1103
Cox18	-1099
Timmdc1	-816
Sdha	-746
Acad9	-691
Ndufb7	-650
Ndufa6	-561
Ndufa1	-470
Uqcr11	-114
mt-Nd3	257
Ndufaf6	359
Uqcr10	654
Taco1	754
Ndufs6	991
Cox5b	1153
Ndufv3	1179
Ndufa13	1623
Cox19	1642
Ndufa3	1807
Ndufaf7	1850
Ndufs7	1885
Lrpprc	2494
Ndufa12	3482
Trap1	4979
Tmem186	6996

---

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

	1054
set	SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize	13
pANOVA	0.0149
s.dist	-0.39
p.adjustANOVA	0.0725

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Spcs3	-7821
Pax6	-6309
Spcs2	-6276
Spcs1	-5474
Tcf7l2	-5464
Sec11c	-4609
Grp	-4260
Dpp4	-2461
Gng13	-1953
Pcsk1	-731
Sec11a	-585
Ctnnb1	1478
Gnb3	4560

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Spcs3	-7821
Pax6	-6309
Spcs2	-6276
Spcs1	-5474
Tcf7l2	-5464
Sec11c	-4609
Grp	-4260
Dpp4	-2461
Gng13	-1953
Pcsk1	-731
Sec11a	-585
Ctnnb1	1478
Gnb3	4560

---

PHOSPHORYLATION OF THE APC C

PHOSPHORYLATION OF THE APC C

	699
set	PHOSPHORYLATION OF THE APC C
setSize	18
pANOVA	0.00469
s.dist	-0.385
p.adjustANOVA	0.0303

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2d1	-8221
Ube2e1	-7973
Anapc10	-7447
Cdk1	-6989
Cdc26	-6729
Cdc16	-6482
Cdc27	-5031
Ube2s	-4651
Anapc7	-4519
Anapc16	-4035
Cdc23	-3456
Anapc4	-3097
Anapc15	-2459
Anapc11	-2257
Plk1	-337
Anapc1	5839
Anapc5	5965
Anapc2	7413

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2d1	-8221
Ube2e1	-7973
Anapc10	-7447
Cdk1	-6989
Cdc26	-6729
Cdc16	-6482
Cdc27	-5031
Ube2s	-4651
Anapc7	-4519
Anapc16	-4035
Cdc23	-3456
Anapc4	-3097
Anapc15	-2459
Anapc11	-2257
Plk1	-337
Anapc1	5839
Anapc5	5965
Anapc2	7413

---

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

	40
set	ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize	20
pANOVA	0.0029
s.dist	-0.385
p.adjustANOVA	0.0201

Top enriched genes

Top 20 genes

GeneID	Gene Rank
P2ry12	-8001
Gng10	-7642
Gng11	-6965
Gnai3	-6812
Gnai1	-6455
Gng2	-6301
Gnb4	-5817
Gnb5	-4608
Gnb2	-3579
Gng12	-3211
Gng5	-2765
Gng3	-2285
Gnai2	-2236
Gng13	-1953
Gng7	-1332
Gngt2	-973
Gnb1	-707
Gng8	1182
Gnb3	4560
Gng4	5427

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
P2ry12	-8001
Gng10	-7642
Gng11	-6965
Gnai3	-6812
Gnai1	-6455
Gng2	-6301
Gnb4	-5817
Gnb5	-4608
Gnb2	-3579
Gng12	-3211
Gng5	-2765
Gng3	-2285
Gnai2	-2236
Gng13	-1953
Gng7	-1332
Gngt2	-973
Gnb1	-707
Gng8	1182
Gnb3	4560
Gng4	5427

---

SYNAPTIC ADHESION LIKE MOLECULES

SYNAPTIC ADHESION LIKE MOLECULES

	1033
set	SYNAPTIC ADHESION LIKE MOLECULES
setSize	21
pANOVA	0.00231
s.dist	0.384
p.adjustANOVA	0.017

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ptprs	8609
Ptprf	8311
Grin2d	8047
Grin1	7424
Lrfn4	7355
Lrfn1	6937
Grin2b	6801
Dlg4	6247
Ptprd	6013
Flot2	5644
Lrfn3	5256
Grin2a	4970
Lrfn2	3928
Gria1	3626
Grin2c	2567
Flot1	2126
Gria4	716
Dlg3	-140
Gria3	-3696
Rtn3	-6403

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ptprs	8609
Ptprf	8311
Grin2d	8047
Grin1	7424
Lrfn4	7355
Lrfn1	6937
Grin2b	6801
Dlg4	6247
Ptprd	6013
Flot2	5644
Lrfn3	5256
Grin2a	4970
Lrfn2	3928
Gria1	3626
Grin2c	2567
Flot1	2126
Gria4	716
Dlg3	-140
Gria3	-3696
Rtn3	-6403
Dlg1	-6962

---

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

	374
set	GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
setSize	31
pANOVA	0.000237
s.dist	-0.381
p.adjustANOVA	0.00245

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cdc42	-8020
Mtap	-7909
Gsto1	-7814
Rap1b	-7601
Tcp1	-7383
Capza1	-7276
Hnrnpdl	-6896
Taldo1	-6865
Rala	-5876
Arf1	-5534
Ppia	-5353
Pak2	-4849
Psme2	-4121
Rplp0	-3862
Hspa9	-3340
Cfl1	-3126
Pitpna	-2996
Pdcd4	-2815
Snrpa1	-2396
Aip	-2302

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cdc42	-8020
Mtap	-7909
Gsto1	-7814
Rap1b	-7601
Tcp1	-7383
Capza1	-7276
Hnrnpdl	-6896
Taldo1	-6865
Rala	-5876
Arf1	-5534
Ppia	-5353
Pak2	-4849
Psme2	-4121
Rplp0	-3862
Hspa9	-3340
Cfl1	-3126
Pitpna	-2996
Pdcd4	-2815
Snrpa1	-2396
Aip	-2302
Lcp1	-2082
Hnrnpf	-1008
Hnrnpa2b1	-975
Lmnb1	8
Bola2	324
Sod1	393
Sod2	1697
Mif	1965
Cnn2	2192
Msn	4109
Anxa2	6922

---

SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE

SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE

	1032
set	SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
setSize	87
pANOVA	7.74e-10
s.dist	-0.381
p.adjustANOVA	5.71e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2d1	-8221
Ccne2	-8217
Psmc6	-8204
Ube2e1	-7973
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Orc5	-7806
Orc6	-7773
Skp1	-7764
Psma6	-7580
Cul1	-7450
Anapc10	-7447
Orc4	-7371
Psma2	-7177
Psmd6	-7172
Mcm3	-7063
Psmf1	-7032
Cdc26	-6729
Psma1	-6555

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2d1	-8221
Ccne2	-8217
Psmc6	-8204
Ube2e1	-7973
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Orc5	-7806
Orc6	-7773
Skp1	-7764
Psma6	-7580
Cul1	-7450
Anapc10	-7447
Orc4	-7371
Psma2	-7177
Psmd6	-7172
Mcm3	-7063
Psmf1	-7032
Cdc26	-6729
Psma1	-6555
Cdc16	-6482
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064
Cdc27	-5031
Psma4	-4815
Rbx1	-4727
Ube2s	-4651
Psmd5	-4603
Psmb3	-4590
Anapc7	-4519
Psma3	-4517
Ubb	-4221
Rps27a	-4124
Psme2	-4121
Mcm4	-4077
Anapc16	-4035
Psma7	-3980
Psma8	-3884
Ccne1	-3683
Mcm5	-3618
Cdc23	-3456
Psmd9	-3332
Anapc4	-3097
Anapc15	-2459
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Anapc11	-2257
Mcm8	-2252
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Psmb4	-1483
Orc3	-1296
Mcm6	-1096
Cdt1	-1095
Fzr1	-1003
Skp2	-450
Psmd11	-127
Mcm2	-30
Psmc4	123
Mcm7	442
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Ccna1	3446
Ubc	3480
Psme4	3590
Uba52	3691
Ccna2	5456
Anapc1	5839
Anapc5	5965
Cdk2	6752
Anapc2	7413

---

METHYLATION

METHYLATION

	561
set	METHYLATION
setSize	11
pANOVA	0.0299
s.dist	-0.378
p.adjustANOVA	0.117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gsto1	-7814
Mat2a	-7551
Mat2b	-7543
N6amt1	-7197
Tpmt	-6187
Ahcy	-4611
Comt	-4026
Mtrr	-418
Trmt112	2118
As3mt	2458
Mtr	8136

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gsto1	-7814
Mat2a	-7551
Mat2b	-7543
N6amt1	-7197
Tpmt	-6187
Ahcy	-4611
Comt	-4026
Mtrr	-418
Trmt112	2118
As3mt	2458
Mtr	8136

---

ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY

	36
set	ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize	13
pANOVA	0.0183
s.dist	0.378
p.adjustANOVA	0.0847

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy6	8807
Adcy4	8795
Adcy5	7460
Adcy8	7205
Adcy2	6106
Adcy9	5535
Adcy3	5523
Adcy7	5402
Gnal	4616
Adcy1	3287
Gnai2	-2236
Gnai1	-6455
Gnai3	-6812

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy6	8807
Adcy4	8795
Adcy5	7460
Adcy8	7205
Adcy2	6106
Adcy9	5535
Adcy3	5523
Adcy7	5402
Gnal	4616
Adcy1	3287
Gnai2	-2236
Gnai1	-6455
Gnai3	-6812

---

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

	1
set	A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize	26
pANOVA	0.000917
s.dist	0.376
p.adjustANOVA	0.00766

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cspg4	8443
Ncan	8140
Gpc2	8054
Sdc4	7950
Agrn	7772
Bcan	7329
Xylt2	6935
Gpc4	6870
Gpc3	5369
B3gat1	5208
Sdc3	4437
Hspg2	4411
Gpc1	4370
Bgn	4058
Vcan	4052
B4galt7	3013
Xylt1	2354
Gpc6	1263
B3galt6	288
B3gat2	271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cspg4	8443
Ncan	8140
Gpc2	8054
Sdc4	7950
Agrn	7772
Bcan	7329
Xylt2	6935
Gpc4	6870
Gpc3	5369
B3gat1	5208
Sdc3	4437
Hspg2	4411
Gpc1	4370
Bgn	4058
Vcan	4052
B4galt7	3013
Xylt1	2354
Gpc6	1263
B3galt6	288
B3gat2	271
Dcn	238
Sdc1	-59
Gpc5	-316
Cspg5	-584
B3gat3	-1287
Sdc2	-4724

---

ORC1 REMOVAL FROM CHROMATIN

ORC1 REMOVAL FROM CHROMATIN

	668
set	ORC1 REMOVAL FROM CHROMATIN
setSize	68
pANOVA	8.69e-08
s.dist	-0.375
p.adjustANOVA	3.63e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Orc5	-7806
Orc6	-7773
Skp1	-7764
Psma6	-7580
Cul1	-7450
Orc4	-7371
Psma2	-7177
Psmd6	-7172
Mcm3	-7063
Psmf1	-7032
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5506

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Orc5	-7806
Orc6	-7773
Skp1	-7764
Psma6	-7580
Cul1	-7450
Orc4	-7371
Psma2	-7177
Psmd6	-7172
Mcm3	-7063
Psmf1	-7032
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064
Psma4	-4815
Rbx1	-4727
Psmd5	-4603
Psmb3	-4590
Psma3	-4517
Ubb	-4221
Rps27a	-4124
Psme2	-4121
Mcm4	-4077
Psma7	-3980
Psma8	-3884
Mcm5	-3618
Psmd9	-3332
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Mcm8	-2252
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Psmb4	-1483
Orc3	-1296
Mcm6	-1096
Cdt1	-1095
Skp2	-450
Psmd11	-127
Mcm2	-30
Psmc4	123
Mcm7	442
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Ccna1	3446
Ubc	3480
Psme4	3590
Uba52	3691
Ccna2	5456
Cdk2	6752

---

PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR

PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR

	682
set	PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR
setSize	20
pANOVA	0.00373
s.dist	-0.375
p.adjustANOVA	0.0247

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rfc3	-8029
Apex1	-7963
Pole4	-7961
Pcna	-7539
Pole3	-6994
Rfc4	-6968
Rpa3	-6924
Rfc5	-4478
Pold2	-4368
Rpa2	-4351
Polb	-4253
Fen1	-3967
Rpa1	-3830
Pold4	-3362
Pole	152
Pold3	2035
Rfc2	3274
Rfc1	3955
Pold1	4153
Lig1	8705

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rfc3	-8029
Apex1	-7963
Pole4	-7961
Pcna	-7539
Pole3	-6994
Rfc4	-6968
Rpa3	-6924
Rfc5	-4478
Pold2	-4368
Rpa2	-4351
Polb	-4253
Fen1	-3967
Rpa1	-3830
Pold4	-3362
Pole	152
Pold3	2035
Rfc2	3274
Rfc1	3955
Pold1	4153
Lig1	8705

---

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

	1053
set	SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
setSize	12
pANOVA	0.025
s.dist	-0.374
p.adjustANOVA	0.104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pla2g7	-8174
Spcs3	-7821
Bche	-6522
Spcs2	-6276
Spcs1	-5474
Sec11c	-4609
Klf4	-4236
Pcsk1	-731
Sec11a	-585
Igf1	-186
Crhr2	1636
Ache	7823

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pla2g7	-8174
Spcs3	-7821
Bche	-6522
Spcs2	-6276
Spcs1	-5474
Sec11c	-4609
Klf4	-4236
Pcsk1	-731
Sec11a	-585
Igf1	-186
Crhr2	1636
Ache	7823

---

SCF SKP2 MEDIATED DEGRADATION OF P27 P21

SCF SKP2 MEDIATED DEGRADATION OF P27 P21

	910
set	SCF SKP2 MEDIATED DEGRADATION OF P27 P21
setSize	59
pANOVA	7.83e-07
s.dist	-0.372
p.adjustANOVA	2.2e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ccne2	-8217
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Skp1	-7764
Psma6	-7580
Cul1	-7450
Cdkn1b	-7418
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ccne2	-8217
Psmc6	-8204
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Skp1	-7764
Psma6	-7580
Cul1	-7450
Cdkn1b	-7418
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Psmc2	-5064
Ccnd1	-4876
Psma4	-4815
Psmd5	-4603
Psmb3	-4590
Psma3	-4517
Ubb	-4221
Rps27a	-4124
Psme2	-4121
Psma7	-3980
Ccne1	-3683
Psmd9	-3332
Cks1b	-3106
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Psmb4	-1483
Skp2	-450
Psmd11	-127
Psmc4	123
Cdk4	372
Psme1	709
Psmb5	728
Psmd1	1046
Cdkn1a	1167
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Ccna1	3446
Ubc	3480
Uba52	3691
Ccna2	5456
Cdk2	6752

---

PROTEIN UBIQUITINATION

PROTEIN UBIQUITINATION

	754
set	PROTEIN UBIQUITINATION
setSize	70
pANOVA	7.66e-08
s.dist	-0.372
p.adjustANOVA	3.34e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8221
Ube2v2	-8214
Ube2q2	-8178
Ube2d3	-8173
Uchl3	-8038
Ube2e1	-7973
Ube2b	-7942
Ube2a	-7921
Ube2l3	-7831
Ube2n	-7815
Ube2k	-7805
Ube2d2a	-7701
Pcna	-7539
Pex13	-7516
Pex2	-7320
Selenos	-7112
Ube2j2	-6881

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8221
Ube2v2	-8214
Ube2q2	-8178
Ube2d3	-8173
Uchl3	-8038
Ube2e1	-7973
Ube2b	-7942
Ube2a	-7921
Ube2l3	-7831
Ube2n	-7815
Ube2k	-7805
Ube2d2a	-7701
Pcna	-7539
Pex13	-7516
Pex2	-7320
Selenos	-7112
Ube2j2	-6881
Rnf181	-6841
Wdr61	-6291
Bcl10	-6256
Rnf152	-6149
Derl1	-5942
H2-D1	-5834
Ube2r2	-5535
Cdc73	-5406
H2bc6	-5191
H2bc21	-5030
Wac	-4869
H2bc4	-4786
Ube2s	-4651
H2-Q7	-4557
Otulin	-4523
Cdc34	-4472
Ubb	-4221
Rps27a	-4124
Rraga	-3744
Ube2t	-3528
Uba6	-3395
H2-Q2	-3151
Rad18	-3031
Leo1	-2492
Usp9x	-2427
Pex14	-2364
Rnf144a	-1704
Ube2z	-1185
Ctr9	-1053
Pex12	172
H2-Q10	705
Hltf	1250
Vcp	1694
Pex10	2167
Usp5	2235
Shprh	2247
Ube2h	2263
Ube2g2	2747
Usp7	2984
Ubc	3480
H2bc12	3667
Uba52	3691
Rnf40	4188
Uba1	4503
Paf1	4791
Pex5	5912
Tmem129	5961
Rtf1	6095
Prkdc	7225
Rnf20	9017

---

PROCESSING AND ACTIVATION OF SUMO

PROCESSING AND ACTIVATION OF SUMO

	738
set	PROCESSING AND ACTIVATION OF SUMO
setSize	10
pANOVA	0.0422
s.dist	-0.371
p.adjustANOVA	0.147

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sumo2	-7743
Sumo1	-7652
Rwdd3	-6572
Sumo3	-5431
Uba2	-4592
Senp2	-2623
Ube2i	-2351
Sae1	-35
Senp5	2142
Senp1	5794

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sumo2	-7743
Sumo1	-7652
Rwdd3	-6572
Sumo3	-5431
Uba2	-4592
Senp2	-2623
Ube2i	-2351
Sae1	-35
Senp5	2142
Senp1	5794

---

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

	331
set	FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize	18
pANOVA	0.00698
s.dist	-0.367
p.adjustANOVA	0.0403

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atp5c1	-8076
Atp5pb	-7499
Dmac2l	-7278
mt-Atp6	-5071
Atp5b	-4886
Atp5h	-4812
Atp5o	-4698
Atp5l	-4684
Atp5a1	-4502
Atp5g3	-4458
Atp5g2	-3059
Atp5j2	-1520
Atp5e	-1120
Atp5j	-1104
Atp5d	320
Atp5g1	1349
Atp5k	2050
mt-Atp8	7353

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atp5c1	-8076
Atp5pb	-7499
Dmac2l	-7278
mt-Atp6	-5071
Atp5b	-4886
Atp5h	-4812
Atp5o	-4698
Atp5l	-4684
Atp5a1	-4502
Atp5g3	-4458
Atp5g2	-3059
Atp5j2	-1520
Atp5e	-1120
Atp5j	-1104
Atp5d	320
Atp5g1	1349
Atp5k	2050
mt-Atp8	7353

---

COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS

	170
set	COMPLEX I BIOGENESIS
setSize	56
pANOVA	2.06e-06
s.dist	-0.367
p.adjustANOVA	4.67e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ndufaf1	-7780
Ndufaf4	-7557
Ndufv2	-7287
Nubpl	-7180
mt-Nd2	-7057
Ndufc2	-6893
mt-Nd6	-6545
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
mt-Nd1	-5998
Ndufaf2	-5957
mt-Nd5	-5921
Ndufb5	-5763
Ndufs1	-5653
Ndufb11	-4979
Ndufs8	-4550
Ndufs3	-4358
Ndufa10	-4299
Ndufab1	-4269

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ndufaf1	-7780
Ndufaf4	-7557
Ndufv2	-7287
Nubpl	-7180
mt-Nd2	-7057
Ndufc2	-6893
mt-Nd6	-6545
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
mt-Nd1	-5998
Ndufaf2	-5957
mt-Nd5	-5921
Ndufb5	-5763
Ndufs1	-5653
Ndufb11	-4979
Ndufs8	-4550
Ndufs3	-4358
Ndufa10	-4299
Ndufab1	-4269
Ndufb4	-4254
Ndufb9	-4240
Ndufb3	-4238
Ndufb8	-3922
Ndufb6	-3352
Tmem126b	-3342
Ndufa11	-3129
Ndufb10	-2954
Ecsit	-2884
Ndufa9	-2857
Ndufs5	-2848
Ndufa7	-2650
Ndufs2	-2591
Ndufb2	-2480
Ndufc1	-2357
Ndufa8	-1983
Ndufv1	-1558
Ndufa2	-1531
Ndufa5	-1343
Ndufaf3	-1245
Ndufb1	-1103
Timmdc1	-816
Acad9	-691
Ndufb7	-650
Ndufa6	-561
Ndufa1	-470
mt-Nd3	257
Ndufaf6	359
Ndufs6	991
Ndufv3	1179
Ndufa13	1623
Ndufa3	1807
Ndufaf7	1850
Ndufs7	1885
Ndufa12	3482
Tmem186	6996

---

APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1

APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1

	62
set	APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
setSize	71
pANOVA	9.26e-08
s.dist	-0.367
p.adjustANOVA	3.64e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2d1	-8221
Psmc6	-8204
Ube2e1	-7973
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Psma6	-7580
Anapc10	-7447
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Cdc26	-6729
Psma1	-6555
Cdc16	-6482
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2d1	-8221
Psmc6	-8204
Ube2e1	-7973
Psmd14	-7965
Psmd12	-7878
Psmb9	-7862
Psma6	-7580
Anapc10	-7447
Psma2	-7177
Psmd6	-7172
Psmf1	-7032
Cdc26	-6729
Psma1	-6555
Cdc16	-6482
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5506
Psmd10	-5497
Psmb7	-5401
Pttg1	-5340
Psmc2	-5064
Cdc27	-5031
Aurka	-4987
Psma4	-4815
Ube2s	-4651
Psmd5	-4603
Psmb3	-4590
Anapc7	-4519
Psma3	-4517
Ubb	-4221
Rps27a	-4124
Psme2	-4121
Anapc16	-4035
Psma7	-3980
Psma8	-3884
Rb1	-3755
Cdc23	-3456
Psmd9	-3332
Anapc4	-3097
Anapc15	-2459
Psmd13	-2449
Sem1	-2432
Psme3	-2373
Psmc3	-2347
Anapc11	-2257
Psmb10	-2155
Psmc1	-1692
Psmb6	-1661
Psmb2	-1638
Psmc5	-1555
Psmb4	-1483
Fzr1	-1003
Skp2	-450
Plk1	-337
Psmd11	-127
Psmc4	123
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1453
Psmd4	2248
Psmd3	2918
Psmd2	3350
Ubc	3480
Psme4	3590
Uba52	3691
Anapc1	5839
Anapc5	5965
Cdc20	6094
Anapc2	7413

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report