Mitch Report

date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	x
0610005C13Rik	1.7086294
0610009B22Rik	-2.3583781
0610009E02Rik	-0.4921631
0610009L18Rik	-1.5061599
0610010K14Rik	-0.7608005
0610012G03Rik	-0.6314820

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genesets	1604
num_genes_in_profile	17472
duplicated_genes_present	0
num_profile_genes_in_sets	8440
num_profile_genes_not_in_sets	9032

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	425
num_genesets_included	1179

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	1.40e-04	-0.695	1.53e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.93e-04	0.681	2.02e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	6.28e-05	0.561	8.05e-04
ENDOSOMAL VACUOLAR PATHWAY	10	3.87e-03	-0.527	2.55e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.82e-03	-0.520	1.97e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	4.31e-06	0.511	8.47e-05
RETINOID CYCLE DISEASE EVENTS	10	7.37e-03	-0.489	4.21e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	6.36e-06	-0.484	1.12e-04
LGI ADAM INTERACTIONS	14	2.76e-03	0.462	1.95e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	9.94e-03	0.449	5.35e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.15e-04	-0.449	4.80e-03
P75NTR REGULATES AXONOGENESIS	10	1.52e-02	-0.443	7.35e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	1.15e-02	0.440	6.03e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	15	3.17e-03	-0.440	2.14e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	1.12e-03	0.421	9.17e-03
CD28 DEPENDENT VAV1 PATHWAY	11	1.75e-02	-0.414	8.14e-02
RORA ACTIVATES GENE EXPRESSION	18	2.57e-03	0.410	1.85e-02
MITOCHONDRIAL TRANSLATION	93	1.30e-11	-0.406	2.56e-09
RECEPTOR MEDIATED MITOPHAGY	11	2.00e-02	-0.405	8.87e-02
CRISTAE FORMATION	31	1.03e-04	-0.403	1.22e-03
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.53e-03	-0.399	1.19e-02
METABOLISM OF POLYAMINES	58	1.57e-07	-0.398	5.98e-06
PENTOSE PHOSPHATE PATHWAY	13	1.30e-02	-0.398	6.51e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	4.45e-04	-0.398	4.27e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	4.28e-07	-0.398	1.33e-05
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	2.78e-03	-0.396	1.95e-02
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	3.26e-08	-0.396	1.67e-06
SIGNALING BY LEPTIN	10	3.01e-02	0.396	1.17e-01
TIGHT JUNCTION INTERACTIONS	17	4.73e-03	-0.396	3.03e-02
UNWINDING OF DNA	12	1.85e-02	-0.393	8.46e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.46e-06	-0.391	7.43e-05
RESPIRATORY ELECTRON TRANSPORT	102	1.00e-11	-0.390	2.36e-09
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	1.49e-02	-0.390	7.24e-02
PHOSPHORYLATION OF THE APC C	18	4.68e-03	-0.385	3.02e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	2.89e-03	-0.385	2.00e-02
SYNAPTIC ADHESION LIKE MOLECULES	21	2.30e-03	0.384	1.70e-02
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	7.63e-10	-0.382	5.62e-08
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	2.36e-04	-0.382	2.44e-03
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.82e-02	0.378	8.46e-02
METHYLATION	11	2.99e-02	-0.378	1.17e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	9.12e-04	0.376	7.62e-03
ORC1 REMOVAL FROM CHROMATIN	68	8.60e-08	-0.375	3.57e-06
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	3.71e-03	-0.375	2.46e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	2.49e-02	-0.374	1.04e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	7.76e-07	-0.372	2.18e-05
PROTEIN UBIQUITINATION	70	7.61e-08	-0.372	3.32e-06
PROCESSING AND ACTIVATION OF SUMO	10	4.21e-02	-0.371	1.47e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	6.95e-03	-0.367	4.02e-02
COMPLEX I BIOGENESIS	56	2.04e-06	-0.367	4.63e-05
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	9.15e-08	-0.367	3.60e-06

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN	10	1.40e-04	-0.695000	1.53e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.93e-04	0.681000	2.02e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	6.28e-05	0.561000	8.05e-04
ENDOSOMAL VACUOLAR PATHWAY	10	3.87e-03	-0.527000	2.55e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.82e-03	-0.520000	1.97e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	4.31e-06	0.511000	8.47e-05
RETINOID CYCLE DISEASE EVENTS	10	7.37e-03	-0.489000	4.21e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	6.36e-06	-0.484000	1.12e-04
LGI ADAM INTERACTIONS	14	2.76e-03	0.462000	1.95e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	9.94e-03	0.449000	5.35e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.15e-04	-0.449000	4.80e-03
P75NTR REGULATES AXONOGENESIS	10	1.52e-02	-0.443000	7.35e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	1.15e-02	0.440000	6.03e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	15	3.17e-03	-0.440000	2.14e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	1.12e-03	0.421000	9.17e-03
CD28 DEPENDENT VAV1 PATHWAY	11	1.75e-02	-0.414000	8.14e-02
RORA ACTIVATES GENE EXPRESSION	18	2.57e-03	0.410000	1.85e-02
MITOCHONDRIAL TRANSLATION	93	1.30e-11	-0.406000	2.56e-09
RECEPTOR MEDIATED MITOPHAGY	11	2.00e-02	-0.405000	8.87e-02
CRISTAE FORMATION	31	1.03e-04	-0.403000	1.22e-03
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.53e-03	-0.399000	1.19e-02
METABOLISM OF POLYAMINES	58	1.57e-07	-0.398000	5.98e-06
PENTOSE PHOSPHATE PATHWAY	13	1.30e-02	-0.398000	6.51e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	4.45e-04	-0.398000	4.27e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	4.28e-07	-0.398000	1.33e-05
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	2.78e-03	-0.396000	1.95e-02
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	3.26e-08	-0.396000	1.67e-06
SIGNALING BY LEPTIN	10	3.01e-02	0.396000	1.17e-01
TIGHT JUNCTION INTERACTIONS	17	4.73e-03	-0.396000	3.03e-02
UNWINDING OF DNA	12	1.85e-02	-0.393000	8.46e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.46e-06	-0.391000	7.43e-05
RESPIRATORY ELECTRON TRANSPORT	102	1.00e-11	-0.390000	2.36e-09
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	1.49e-02	-0.390000	7.24e-02
PHOSPHORYLATION OF THE APC C	18	4.68e-03	-0.385000	3.02e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	2.89e-03	-0.385000	2.00e-02
SYNAPTIC ADHESION LIKE MOLECULES	21	2.30e-03	0.384000	1.70e-02
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	7.63e-10	-0.382000	5.62e-08
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	2.36e-04	-0.382000	2.44e-03
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.82e-02	0.378000	8.46e-02
METHYLATION	11	2.99e-02	-0.378000	1.17e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	9.12e-04	0.376000	7.62e-03
ORC1 REMOVAL FROM CHROMATIN	68	8.60e-08	-0.375000	3.57e-06
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	3.71e-03	-0.375000	2.46e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	2.49e-02	-0.374000	1.04e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	7.76e-07	-0.372000	2.18e-05
PROTEIN UBIQUITINATION	70	7.61e-08	-0.372000	3.32e-06
PROCESSING AND ACTIVATION OF SUMO	10	4.21e-02	-0.371000	1.47e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	6.95e-03	-0.367000	4.02e-02
COMPLEX I BIOGENESIS	56	2.04e-06	-0.367000	4.63e-05
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	71	9.15e-08	-0.367000	3.60e-06
RHOBTB3 ATPASE CYCLE	10	4.50e-02	-0.366000	1.53e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	1.67e-03	0.363000	1.28e-02
RAB GERANYLGERANYLATION	58	1.84e-06	-0.362000	4.24e-05
E2F MEDIATED REGULATION OF DNA REPLICATION	20	5.08e-03	-0.362000	3.18e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	11	3.78e-02	-0.362000	1.36e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	7.51e-04	-0.362000	6.71e-03
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	6.10e-04	-0.362000	5.57e-03
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	4.51e-06	-0.361000	8.67e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	6.57e-03	-0.360000	3.86e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	64	6.84e-07	-0.359000	1.97e-05
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	4.28e-12	-0.359000	1.26e-09
GLUTATHIONE CONJUGATION	29	8.65e-04	-0.357000	7.39e-03
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.08e-03	0.357000	8.90e-03
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	7.54e-03	-0.354000	4.25e-02
MITOCHONDRIAL PROTEIN IMPORT	63	1.22e-06	-0.354000	3.34e-05
ACTIVATION OF SMO	16	1.44e-02	0.353000	7.09e-02
DNA REPLICATION PRE INITIATION	80	5.23e-08	-0.352000	2.47e-06
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	15	1.83e-02	-0.352000	8.46e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	2.95e-06	-0.352000	6.53e-05
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	51	1.44e-05	-0.351000	2.18e-04
TRIGLYCERIDE CATABOLISM	14	2.37e-02	-0.349000	1.01e-01
INTERLEUKIN 6 SIGNALING	10	5.63e-02	0.349000	1.77e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	83	4.21e-08	-0.348000	2.07e-06
INTERLEUKIN 12 SIGNALING	36	3.03e-04	-0.348000	3.03e-03
S PHASE	154	1.30e-13	-0.346000	6.39e-11
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	60	3.90e-06	-0.345000	8.06e-05
PROTEIN METHYLATION	17	1.41e-02	-0.344000	7.01e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	2.42e-03	-0.344000	1.77e-02
DNA REPLICATION	122	5.69e-11	-0.343000	7.15e-09
HIV TRANSCRIPTION INITIATION	45	6.88e-05	-0.343000	8.45e-04
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	13	3.38e-02	-0.340000	1.24e-01
DEGRADATION OF DVL	56	1.08e-05	-0.340000	1.71e-04
INSULIN RECEPTOR RECYCLING	20	8.63e-03	-0.339000	4.71e-02
PHASE 4 RESTING MEMBRANE POTENTIAL	14	2.84e-02	-0.338000	1.13e-01
CRMPS IN SEMA3A SIGNALING	16	1.94e-02	0.337000	8.66e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	69	1.47e-06	-0.335000	3.68e-05
MET ACTIVATES RAP1 AND RAC1	10	6.64e-02	-0.335000	1.97e-01
DEGRADATION OF AXIN	54	2.09e-05	-0.335000	3.08e-04
G BETA GAMMA SIGNALLING THROUGH CDC42	19	1.19e-02	-0.333000	6.16e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	2.87e-05	-0.332000	4.08e-04
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	60	8.91e-06	-0.332000	1.46e-04
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	3.87e-02	0.331000	1.38e-01
PYRUVATE METABOLISM	27	2.95e-03	-0.331000	2.02e-02
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	1.32e-03	0.328000	1.06e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.63e-13	-0.326000	6.39e-11
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	5.17e-04	0.325000	4.80e-03
MATURATION OF NUCLEOPROTEIN	10	7.47e-02	-0.325000	2.15e-01
DEGRADATION OF GLI1 BY THE PROTEASOME	58	1.98e-05	-0.324000	2.95e-04
RAS PROCESSING	24	6.09e-03	-0.323000	3.62e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	6.32e-02	-0.323000	1.91e-01
NGF STIMULATED TRANSCRIPTION	36	8.22e-04	-0.322000	7.13e-03
PERK REGULATES GENE EXPRESSION	28	3.24e-03	-0.322000	2.17e-02
EARLY PHASE OF HIV LIFE CYCLE	13	4.50e-02	-0.321000	1.53e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	3.64e-07	-0.321000	1.23e-05
STABILIZATION OF P53	55	3.99e-05	-0.320000	5.48e-04
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	3.26e-02	-0.319000	1.22e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.36e-02	-0.319000	6.82e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	5.68e-02	-0.318000	1.78e-01
PHASE II CONJUGATION OF COMPOUNDS	63	1.32e-05	-0.317000	2.02e-04
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	3.98e-02	0.317000	1.41e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	53	6.60e-05	0.317000	8.28e-04
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	14	4.10e-02	-0.315000	1.44e-01
PROCESSING OF SMDT1	16	2.91e-02	-0.315000	1.15e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	8.62e-02	0.313000	2.38e-01
DNA STRAND ELONGATION	32	2.22e-03	-0.312000	1.65e-02
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	27	4.96e-03	0.312000	3.14e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	24	8.19e-03	-0.312000	4.53e-02
RUNX3 REGULATES NOTCH SIGNALING	13	5.18e-02	0.312000	1.67e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	36	1.28e-03	0.310000	1.03e-02
CELLULAR RESPONSE TO HYPOXIA	73	4.62e-06	-0.310000	8.67e-05
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	69	8.42e-06	-0.310000	1.42e-04
REGULATION OF BACH1 ACTIVITY	11	7.57e-02	-0.309000	2.18e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	3.22e-02	0.309000	1.21e-01
EUKARYOTIC TRANSLATION INITIATION	115	1.07e-08	-0.309000	6.28e-07
INTERFERON ALPHA BETA SIGNALING	56	6.85e-05	-0.308000	8.45e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	2.23e-03	-0.308000	1.65e-02
MITOTIC G1 PHASE AND G1 S TRANSITION	141	3.42e-10	-0.306000	2.88e-08
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	4.39e-03	-0.306000	2.88e-02
MET ACTIVATES PTK2 SIGNALING	28	5.21e-03	0.305000	3.21e-02
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	9.99e-03	-0.304000	5.35e-02
TRANSLATION	287	1.07e-18	-0.303000	1.26e-15
PROTEIN LOCALIZATION	157	6.06e-11	-0.303000	7.15e-09
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	17	3.09e-02	-0.302000	1.19e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	3.09e-02	0.302000	1.19e-01
ACTIVATION OF RAC1	13	6.02e-02	-0.301000	1.84e-01
DARPP 32 EVENTS	23	1.26e-02	-0.300000	6.45e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	4.13e-06	-0.300000	8.39e-05
APOPTOSIS INDUCED DNA FRAGMENTATION	10	1.01e-01	-0.300000	2.57e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	107	8.79e-08	-0.299000	3.57e-06
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.30e-02	-0.299000	6.51e-02
BUDDING AND MATURATION OF HIV VIRION	27	7.39e-03	-0.298000	4.21e-02
REGULATION OF PTEN STABILITY AND ACTIVITY	68	2.19e-05	-0.298000	3.19e-04
INTERLEUKIN 37 SIGNALING	18	2.94e-02	0.297000	1.16e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	5.86e-03	-0.296000	3.54e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	6.54e-02	-0.295000	1.95e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	22	1.67e-02	-0.295000	7.92e-02
OTHER SEMAPHORIN INTERACTIONS	19	2.66e-02	0.294000	1.08e-01
KINESINS	47	4.99e-04	0.294000	4.71e-03
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	2.71e-02	-0.293000	1.09e-01
INTERLEUKIN 12 FAMILY SIGNALING	43	8.92e-04	-0.293000	7.54e-03
REGULATION OF TLR BY ENDOGENOUS LIGAND	14	5.82e-02	-0.292000	1.80e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	1.26e-04	-0.291000	1.41e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	2.92e-03	-0.291000	2.01e-02
FCERI MEDIATED NF KB ACTIVATION	77	1.05e-05	-0.291000	1.67e-04
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	8.29e-02	-0.289000	2.32e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	85	4.30e-06	-0.288000	8.47e-05
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	24	1.45e-02	-0.288000	7.11e-02
PHASE 2 PLATEAU PHASE	12	8.40e-02	0.288000	2.35e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	4.74e-02	-0.286000	1.58e-01
PYROPTOSIS	21	2.34e-02	-0.286000	9.99e-02
RNA POLYMERASE III CHAIN ELONGATION	18	3.62e-02	-0.285000	1.31e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	96	1.44e-06	-0.285000	3.68e-05
PURINE CATABOLISM	16	4.88e-02	-0.285000	1.61e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	5.70e-02	0.284000	1.78e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	7.85e-06	-0.284000	1.34e-04
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	1.61e-02	-0.284000	7.72e-02
SULFUR AMINO ACID METABOLISM	23	1.87e-02	-0.283000	8.47e-02
TERMINATION OF TRANSLESION DNA SYNTHESIS	31	6.56e-03	-0.282000	3.86e-02
ANTIGEN PROCESSING CROSS PRESENTATION	99	1.26e-06	-0.282000	3.38e-05
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	3.37e-02	-0.281000	1.24e-01
RRNA PROCESSING IN THE MITOCHONDRION	10	1.23e-01	-0.281000	2.94e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	6.85e-02	0.281000	2.01e-01
METABOLISM OF COFACTORS	19	3.40e-02	-0.281000	1.25e-01
SIGNALING BY FGFR2 IIIA TM	19	3.57e-02	-0.278000	1.30e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	7.34e-03	-0.278000	4.21e-02
FORMATION OF APOPTOSOME	10	1.28e-01	-0.278000	3.00e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	17	4.81e-02	-0.277000	1.59e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	4.93e-04	-0.277000	4.69e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	9.02e-03	0.275000	4.90e-02
HEDGEHOG LIGAND BIOGENESIS	62	1.77e-04	-0.275000	1.90e-03
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	6.49e-02	-0.275000	1.94e-01
TRANSLESION SYNTHESIS BY POLK	17	5.02e-02	-0.274000	1.64e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	13	8.68e-02	0.274000	2.38e-01
EUKARYOTIC TRANSLATION ELONGATION	88	8.86e-06	-0.274000	1.46e-04
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.01e-01	-0.273000	2.57e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	6.90e-03	-0.272000	4.02e-02
G1 S DNA DAMAGE CHECKPOINTS	66	1.36e-04	-0.272000	1.50e-03
POLYMERASE SWITCHING	14	7.89e-02	-0.271000	2.22e-01
TRANSLESION SYNTHESIS BY POLH	19	4.12e-02	-0.271000	1.44e-01
MRNA CAPPING	29	1.22e-02	-0.269000	6.23e-02
REGULATION OF RAS BY GAPS	67	1.43e-04	-0.269000	1.54e-03
HS GAG DEGRADATION	21	3.34e-02	0.268000	1.24e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	1.45e-01	-0.266000	3.24e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	1.26e-01	-0.266000	2.99e-01
NEUREXINS AND NEUROLIGINS	54	7.59e-04	0.265000	6.73e-03
FORMATION OF INCISION COMPLEX IN GG NER	43	2.66e-03	-0.265000	1.89e-02
IRON UPTAKE AND TRANSPORT	52	9.74e-04	-0.264000	8.09e-03
LAGGING STRAND SYNTHESIS	20	4.11e-02	-0.264000	1.44e-01
HYALURONAN METABOLISM	16	6.79e-02	0.264000	2.00e-01
INTERLEUKIN 7 SIGNALING	19	4.67e-02	0.264000	1.56e-01
CLEC7A DECTIN 1 SIGNALING	95	9.48e-06	-0.263000	1.53e-04
GLUTATHIONE SYNTHESIS AND RECYCLING	11	1.31e-01	-0.263000	3.06e-01
DNA DAMAGE BYPASS	47	1.87e-03	-0.262000	1.42e-02
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	7.17e-02	-0.260000	2.09e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	27	1.95e-02	-0.260000	8.66e-02
NRAGE SIGNALS DEATH THROUGH JNK	55	8.96e-04	0.259000	7.54e-03
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	1.39e-03	-0.259000	1.10e-02
GP1B IX V ACTIVATION SIGNALLING	11	1.37e-01	0.259000	3.15e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	4.57e-02	0.258000	1.54e-01
RHOC GTPASE CYCLE	74	1.24e-04	0.258000	1.40e-03
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	3.22e-02	-0.258000	1.21e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	4.66e-02	0.257000	1.56e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	7.79e-03	-0.256000	4.37e-02
INTERLEUKIN 15 SIGNALING	12	1.25e-01	0.256000	2.96e-01
MITOPHAGY	29	1.71e-02	-0.256000	8.04e-02
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	2.69e-02	-0.256000	1.09e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	85	4.66e-05	-0.256000	6.24e-04
RHOB GTPASE CYCLE	68	2.77e-04	0.255000	2.84e-03
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	3.45e-02	-0.255000	1.26e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	7.86e-02	-0.254000	2.22e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.28e-01	-0.254000	3.00e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	3.94e-02	-0.254000	1.40e-01
HEME BIOSYNTHESIS	13	1.14e-01	-0.253000	2.79e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS	165	2.20e-08	-0.253000	1.18e-06
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	5.06e-02	0.253000	1.65e-01
SELENOAMINO ACID METABOLISM	110	4.98e-06	-0.252000	9.01e-05
REGULATED NECROSIS	46	3.11e-03	-0.252000	2.11e-02
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	34	1.11e-02	-0.252000	5.83e-02
G2 M CHECKPOINTS	136	4.07e-07	-0.252000	1.30e-05
METABOLISM OF PORPHYRINS	19	5.80e-02	-0.251000	1.80e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	15	9.24e-02	0.251000	2.46e-01
RNA POLYMERASE I PROMOTER ESCAPE	48	2.64e-03	-0.251000	1.88e-02
DERMATAN SULFATE BIOSYNTHESIS	11	1.50e-01	0.250000	3.34e-01
CITRIC ACID CYCLE TCA CYCLE	22	4.26e-02	-0.250000	1.48e-01
CS DS DEGRADATION	14	1.06e-01	0.250000	2.65e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	7.58e-05	0.248000	9.21e-04
HOST INTERACTIONS OF HIV FACTORS	126	1.53e-06	-0.248000	3.75e-05
ENOS ACTIVATION	11	1.54e-01	-0.248000	3.40e-01
CELLULAR RESPONSE TO STARVATION	147	2.27e-07	-0.247000	8.10e-06
TELOMERE C STRAND SYNTHESIS INITIATION	13	1.23e-01	-0.247000	2.94e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	1.09e-04	-0.246000	1.28e-03
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	9.98e-02	-0.245000	2.56e-01
VOLTAGE GATED POTASSIUM CHANNELS	39	8.02e-03	0.245000	4.48e-02
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	1.47e-02	-0.245000	7.18e-02
ERKS ARE INACTIVATED	13	1.26e-01	-0.245000	2.98e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	1.01e-01	0.245000	2.57e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	1.80e-01	-0.245000	3.76e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	7.95e-04	-0.244000	6.97e-03
ANCHORING FIBRIL FORMATION	14	1.16e-01	0.243000	2.81e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	1.04e-01	-0.243000	2.62e-01
DUAL INCISION IN TC NER	64	7.99e-04	-0.242000	6.97e-03
C TYPE LECTIN RECEPTORS CLRS	116	6.78e-06	-0.242000	1.18e-04
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	4.03e-02	-0.242000	1.43e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	5.15e-03	-0.241000	3.19e-02
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	6.30e-02	0.240000	1.91e-01
TNFR2 NON CANONICAL NF KB PATHWAY	82	1.79e-04	-0.239000	1.90e-03
CONDENSATION OF PROPHASE CHROMOSOMES	29	2.60e-02	-0.239000	1.07e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	2.97e-04	-0.239000	3.00e-03
SIGNALING BY NTRK3 TRKC	17	8.94e-02	0.238000	2.42e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	1.41e-01	-0.236000	3.19e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE	36	1.44e-02	-0.236000	7.09e-02
PEROXISOMAL PROTEIN IMPORT	58	1.92e-03	-0.236000	1.45e-02
PHASE 0 RAPID DEPOLARISATION	28	3.21e-02	0.234000	1.21e-01
BILE ACID AND BILE SALT METABOLISM	25	4.30e-02	0.234000	1.48e-01
SUPPRESSION OF PHAGOSOMAL MATURATION	12	1.62e-01	-0.233000	3.52e-01
SIGNALING BY THE B CELL RECEPTOR BCR	104	4.20e-05	-0.233000	5.69e-04
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	2.03e-01	-0.232000	4.07e-01
CDC42 GTPASE CYCLE	154	6.70e-07	0.232000	1.97e-05
FGFR1 LIGAND BINDING AND ACTIVATION	10	2.05e-01	-0.232000	4.07e-01
SEPARATION OF SISTER CHROMATIDS	166	2.68e-07	-0.232000	9.31e-06
HIV INFECTION	222	2.85e-09	-0.232000	1.98e-07
ECM PROTEOGLYCANS	66	1.16e-03	0.231000	9.44e-03
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	8.96e-02	-0.231000	2.42e-01
FERTILIZATION	13	1.50e-01	0.231000	3.34e-01
THE NLRP3 INFLAMMASOME	14	1.36e-01	-0.230000	3.14e-01
TRIGLYCERIDE METABOLISM	24	5.20e-02	-0.229000	1.68e-01
INTERFERON GAMMA SIGNALING	79	4.35e-04	-0.229000	4.20e-03
SIGNALING BY NOTCH4	83	3.45e-04	-0.227000	3.39e-03
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	38	1.57e-02	-0.227000	7.53e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	6.00e-02	-0.227000	1.84e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	9.64e-02	0.226000	2.51e-01
MAPK6 MAPK4 SIGNALING	85	3.12e-04	-0.226000	3.09e-03
CELLULAR RESPONSE TO CHEMICAL STRESS	152	1.76e-06	-0.225000	4.14e-05
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	2.20e-01	0.224000	4.25e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	21	7.62e-02	-0.224000	2.18e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	5.37e-02	-0.223000	1.71e-01
SIGNALING BY FGFR2 IN DISEASE	37	1.92e-02	-0.223000	8.60e-02
METALLOPROTEASE DUBS	25	5.43e-02	-0.222000	1.73e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	6.60e-02	0.222000	1.96e-01
CYTOPROTECTION BY HMOX1	119	3.10e-05	-0.221000	4.35e-04
NONSENSE MEDIATED DECAY NMD	110	6.25e-05	-0.221000	8.05e-04
MISMATCH REPAIR	14	1.52e-01	-0.221000	3.36e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	26	5.15e-02	-0.221000	1.67e-01
INFLUENZA INFECTION	146	4.82e-06	-0.219000	8.89e-05
MITOTIC METAPHASE AND ANAPHASE	208	5.54e-08	-0.219000	2.51e-06
DISEASES OF MITOTIC CELL CYCLE	37	2.14e-02	-0.219000	9.31e-02
ASPARTATE AND ASPARAGINE METABOLISM	11	2.10e-01	-0.218000	4.11e-01
NICOTINAMIDE SALVAGING	15	1.44e-01	-0.218000	3.24e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	2.35e-01	0.217000	4.44e-01
NCAM1 INTERACTIONS	41	1.63e-02	0.217000	7.74e-02
CHOLESTEROL BIOSYNTHESIS	24	6.59e-02	-0.217000	1.96e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES	320	2.80e-11	-0.217000	4.72e-09
NUCLEOTIDE EXCISION REPAIR	109	1.01e-04	-0.216000	1.20e-03
OLFACTORY SIGNALING PATHWAY	33	3.26e-02	0.215000	1.22e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	14	1.66e-01	-0.214000	3.58e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	25	6.45e-02	-0.214000	1.94e-01
ION TRANSPORT BY P TYPE ATPASES	51	8.39e-03	0.213000	4.62e-02
EFFECTS OF PIP2 HYDROLYSIS	27	5.54e-02	0.213000	1.75e-01
NEPHRIN FAMILY INTERACTIONS	23	7.71e-02	0.213000	2.20e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	8.52e-02	0.212000	2.36e-01
GLYCOGEN SYNTHESIS	14	1.70e-01	-0.212000	3.61e-01
CELL CYCLE CHECKPOINTS	244	1.31e-08	-0.212000	7.35e-07
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	1.45e-03	-0.211000	1.14e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	2.05e-01	-0.211000	4.07e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	1.88e-01	-0.211000	3.85e-01
ERK MAPK TARGETS	22	8.71e-02	-0.211000	2.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	1.74e-01	0.210000	3.67e-01
FC EPSILON RECEPTOR FCERI SIGNALING	124	5.55e-05	-0.210000	7.27e-04
PKA MEDIATED PHOSPHORYLATION OF CREB	19	1.14e-01	0.210000	2.78e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	1.75e-02	0.210000	8.14e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	2.20e-02	-0.209000	9.41e-02
PRE NOTCH PROCESSING IN GOLGI	18	1.25e-01	0.209000	2.96e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	9.02e-02	-0.209000	2.43e-01
G PROTEIN BETA GAMMA SIGNALLING	31	4.48e-02	-0.208000	1.53e-01
RRNA PROCESSING	195	5.61e-07	-0.208000	1.70e-05
TCR SIGNALING	102	2.94e-04	-0.208000	2.99e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA	14	1.82e-01	-0.206000	3.77e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	1.30e-01	-0.206000	3.03e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	2.60e-02	0.206000	1.07e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	1.42e-01	-0.205000	3.21e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	5.25e-03	-0.205000	3.21e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	2.62e-01	-0.205000	4.76e-01
SHC MEDIATED CASCADE FGFR1	16	1.58e-01	-0.204000	3.46e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	9.80e-02	0.204000	2.53e-01
G0 AND EARLY G1	25	7.80e-02	-0.204000	2.21e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	18	1.37e-01	-0.202000	3.15e-01
DUAL INCISION IN GG NER	40	2.73e-02	-0.202000	1.10e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	4.88e-02	0.201000	1.61e-01
COPII MEDIATED VESICLE TRANSPORT	66	4.82e-03	-0.201000	3.07e-02
SARS COV 1 INFECTION	48	1.68e-02	-0.200000	7.92e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	2.54e-01	0.199000	4.66e-01
INTERLEUKIN 1 SIGNALING	96	8.55e-04	-0.197000	7.36e-03
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	1.90e-02	0.196000	8.53e-02
INOSITOL PHOSPHATE METABOLISM	46	2.19e-02	0.195000	9.41e-02
FCERI MEDIATED MAPK ACTIVATION	28	7.36e-02	-0.195000	2.14e-01
UCH PROTEINASES	90	1.38e-03	-0.195000	1.10e-02
TRANSCRIPTION OF THE HIV GENOME	67	5.95e-03	-0.194000	3.58e-02
FATTY ACID METABOLISM	146	5.09e-05	-0.194000	6.74e-04
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	66	6.34e-03	-0.194000	3.76e-02
ABC TRANSPORTER DISORDERS	71	4.69e-03	-0.194000	3.02e-02
SIGNALING BY ROBO RECEPTORS	210	1.30e-06	-0.194000	3.39e-05
PROGRAMMED CELL DEATH	188	5.04e-06	-0.193000	9.01e-05
MTORC1 MEDIATED SIGNALLING	24	1.02e-01	-0.193000	2.59e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	68	6.04e-03	-0.193000	3.61e-02
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	10	2.93e-01	0.192000	5.11e-01
DNA DAMAGE RECOGNITION IN GG NER	38	4.05e-02	-0.192000	1.43e-01
CHONDROITIN SULFATE BIOSYNTHESIS	18	1.59e-01	0.192000	3.46e-01
RAF ACTIVATION	34	5.30e-02	-0.192000	1.70e-01
PKMTS METHYLATE HISTONE LYSINES	49	2.10e-02	0.191000	9.19e-02
SIALIC ACID METABOLISM	32	6.28e-02	-0.190000	1.91e-01
FATTY ACYL COA BIOSYNTHESIS	32	6.32e-02	-0.190000	1.91e-01
PEROXISOMAL LIPID METABOLISM	26	9.40e-02	-0.190000	2.47e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	2.36e-01	-0.190000	4.46e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	2.77e-01	0.189000	4.93e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS	19	1.53e-01	-0.189000	3.38e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	3.01e-01	0.189000	5.20e-01
ANTIMICROBIAL PEPTIDES	17	1.79e-01	-0.188000	3.75e-01
INTERFERON SIGNALING	167	2.74e-05	-0.188000	3.94e-04
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	2.07e-01	-0.188000	4.08e-01
COSTIMULATION BY THE CD28 FAMILY	50	2.15e-02	-0.188000	9.31e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	23	1.22e-01	-0.186000	2.94e-01
RHOA GTPASE CYCLE	143	1.24e-04	0.186000	1.40e-03
RUNX2 REGULATES BONE DEVELOPMENT	29	8.46e-02	0.185000	2.36e-01
IRE1ALPHA ACTIVATES CHAPERONES	50	2.39e-02	0.185000	1.01e-01
ARACHIDONIC ACID METABOLISM	40	4.34e-02	-0.185000	1.49e-01
PCP CE PATHWAY	90	2.52e-03	-0.184000	1.83e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	1.19e-01	-0.184000	2.87e-01
N GLYCAN ANTENNAE ELONGATION	15	2.18e-01	-0.184000	4.22e-01
DAG AND IP3 SIGNALING	40	4.47e-02	0.183000	1.53e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS	12	2.71e-01	-0.183000	4.87e-01
NUCLEOBASE BIOSYNTHESIS	15	2.21e-01	-0.182000	4.26e-01
RND2 GTPASE CYCLE	39	4.97e-02	0.182000	1.63e-01
G2 M DNA DAMAGE CHECKPOINT	67	1.04e-02	-0.181000	5.56e-02
SARS COV 2 INFECTION	65	1.17e-02	-0.181000	6.10e-02
SEMA4D IN SEMAPHORIN SIGNALING	24	1.26e-01	0.181000	2.98e-01
INTERLEUKIN 20 FAMILY SIGNALING	14	2.42e-01	0.181000	4.52e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	1.35e-01	-0.180000	3.11e-01
SYNTHESIS OF PA	29	9.31e-02	0.180000	2.46e-01
APOPTOSIS	166	6.52e-05	-0.180000	8.27e-04
BIOLOGICAL OXIDATIONS	125	5.37e-04	-0.179000	4.94e-03
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	2.29e-01	-0.179000	4.36e-01
DISEASES OF PROGRAMMED CELL DEATH	55	2.16e-02	-0.179000	9.34e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	2.47e-01	0.179000	4.58e-01
LAMININ INTERACTIONS	28	1.03e-01	0.178000	2.61e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	9.18e-02	0.178000	2.45e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	8.75e-02	-0.177000	2.39e-01
G1 S SPECIFIC TRANSCRIPTION	27	1.11e-01	-0.177000	2.73e-01
CHROMOSOME MAINTENANCE	102	2.02e-03	-0.177000	1.52e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	2.72e-01	-0.176000	4.87e-01
CHAPERONE MEDIATED AUTOPHAGY	21	1.64e-01	-0.175000	3.56e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	23	1.46e-01	-0.175000	3.26e-01
AMINO ACIDS REGULATE MTORC1	51	3.09e-02	-0.175000	1.19e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	61	1.86e-02	0.174000	8.46e-02
TRAFFICKING OF AMPA RECEPTORS	31	9.34e-02	0.174000	2.46e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	38	6.37e-02	-0.174000	1.92e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	14	2.61e-01	-0.174000	4.74e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	9.01e-02	0.173000	2.43e-01
HIV LIFE CYCLE	142	3.77e-04	-0.173000	3.67e-03
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	3.00e-01	0.173000	5.20e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	2.04e-01	0.173000	4.07e-01
MITOTIC PROPHASE	96	3.55e-03	-0.172000	2.37e-02
TELOMERE MAINTENANCE	79	8.17e-03	-0.172000	4.53e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	1.09e-01	0.172000	2.69e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	18	2.07e-01	0.172000	4.08e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	1.84e-01	-0.172000	3.80e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	5.77e-02	0.171000	1.79e-01
MET PROMOTES CELL MOTILITY	38	6.79e-02	0.171000	2.00e-01
NEDDYLATION	221	1.21e-05	-0.171000	1.88e-04
BETA CATENIN PHOSPHORYLATION CASCADE	16	2.38e-01	-0.171000	4.47e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	3.50e-01	-0.171000	5.66e-01
SEMAPHORIN INTERACTIONS	64	1.85e-02	0.170000	8.46e-02
RHO GTPASES ACTIVATE KTN1	11	3.30e-01	-0.169000	5.44e-01
LATE ENDOSOMAL MICROAUTOPHAGY	32	9.79e-02	-0.169000	2.53e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	1.09e-01	-0.169000	2.69e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	2.15e-01	0.169000	4.18e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	13	2.92e-01	-0.169000	5.11e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	8.90e-02	-0.169000	2.42e-01
CARGO CONCENTRATION IN THE ER	31	1.05e-01	-0.168000	2.64e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	2.17e-01	0.168000	4.20e-01
CROSSLINKING OF COLLAGEN FIBRILS	16	2.45e-01	0.168000	4.57e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	1.39e-01	-0.168000	3.17e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	12	3.16e-01	0.167000	5.31e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	3.38e-01	-0.167000	5.52e-01
GLUCAGON TYPE LIGAND RECEPTORS	26	1.41e-01	-0.167000	3.19e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING	10	3.61e-01	-0.167000	5.73e-01
RAC1 GTPASE CYCLE	179	1.22e-04	0.167000	1.39e-03
INFLAMMASOMES	18	2.21e-01	-0.167000	4.26e-01
SHC1 EVENTS IN EGFR SIGNALING	11	3.40e-01	-0.166000	5.53e-01
MITOTIC SPINDLE CHECKPOINT	96	4.98e-03	-0.166000	3.14e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	3.01e-01	0.166000	5.20e-01
INITIAL TRIGGERING OF COMPLEMENT	13	3.04e-01	0.165000	5.23e-01
PI 3K CASCADE FGFR2	17	2.41e-01	-0.164000	4.51e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	3.52e-02	-0.164000	1.29e-01
FGFR2 LIGAND BINDING AND ACTIVATION	13	3.06e-01	-0.164000	5.23e-01
G ALPHA 12 13 SIGNALLING EVENTS	75	1.41e-02	0.164000	7.00e-02
CD28 CO STIMULATION	31	1.15e-01	-0.164000	2.79e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	110	3.06e-03	-0.164000	2.09e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	1.66e-01	-0.163000	3.58e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	1.96e-01	-0.163000	3.98e-01
DEADENYLATION OF MRNA	25	1.59e-01	-0.163000	3.46e-01
DAP12 INTERACTIONS	30	1.23e-01	-0.163000	2.94e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	1.06e-01	-0.163000	2.65e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	64	2.52e-02	0.162000	1.05e-01
CYTOSOLIC TRNA AMINOACYLATION	24	1.71e-01	-0.162000	3.61e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	3.13e-01	0.161000	5.31e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	3.54e-01	-0.161000	5.68e-01
HDMS DEMETHYLATE HISTONES	28	1.41e-01	0.161000	3.19e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	87	9.66e-03	0.161000	5.22e-02
SIGNALING BY INSULIN RECEPTOR	64	2.66e-02	-0.160000	1.08e-01
NUCLEAR ENVELOPE NE REASSEMBLY	65	2.55e-02	-0.160000	1.05e-01
TRANSCRIPTIONAL REGULATION BY MECP2	60	3.20e-02	0.160000	1.21e-01
SCAVENGING OF HEME FROM PLASMA	11	3.59e-01	-0.160000	5.70e-01
CTLA4 INHIBITORY SIGNALING	20	2.17e-01	-0.160000	4.20e-01
SENSORY PROCESSING OF SOUND	61	3.16e-02	0.159000	1.21e-01
RND3 GTPASE CYCLE	38	9.15e-02	0.158000	2.45e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	2.10e-01	0.158000	4.11e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	3.64e-01	-0.158000	5.76e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	3.25e-01	0.158000	5.38e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	9.70e-02	-0.158000	2.52e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	2.47e-01	0.158000	4.58e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	8.14e-02	-0.157000	2.29e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	3.46e-01	0.157000	5.60e-01
CELL CYCLE MITOTIC	476	5.36e-09	-0.157000	3.32e-07
SPHINGOLIPID METABOLISM	79	1.62e-02	-0.156000	7.74e-02
PI 3K CASCADE FGFR1	16	2.79e-01	-0.156000	4.97e-01
DISEASES OF GLYCOSYLATION	126	2.48e-03	0.156000	1.80e-02
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	1.05e-01	0.156000	2.64e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	3.15e-01	0.155000	5.31e-01
BASE EXCISION REPAIR	57	4.28e-02	-0.155000	1.48e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	2.69e-01	0.155000	4.84e-01
GLYCOSPHINGOLIPID METABOLISM	38	9.86e-02	-0.155000	2.54e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	2.71e-01	-0.154000	4.87e-01
G PROTEIN MEDIATED EVENTS	51	5.74e-02	0.154000	1.78e-01
PLATELET SENSITIZATION BY LDL	15	3.03e-01	-0.154000	5.22e-01
FRS MEDIATED FGFR2 SIGNALING	19	2.46e-01	-0.154000	4.58e-01
METABOLISM OF RNA	646	3.38e-11	-0.153000	4.99e-09
NEUTROPHIL DEGRANULATION	393	2.05e-07	-0.153000	7.55e-06
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	3.82e-02	-0.152000	1.37e-01
SYNTHESIS OF PE	13	3.42e-01	0.152000	5.56e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	3.83e-01	-0.152000	5.94e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	3.43e-01	-0.152000	5.57e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	1.98e-01	-0.152000	4.01e-01
GPVI MEDIATED ACTIVATION CASCADE	31	1.44e-01	-0.152000	3.24e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	119	4.46e-03	0.151000	2.91e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT	96	1.07e-02	-0.151000	5.70e-02
M PHASE	342	1.74e-06	-0.151000	4.14e-05
RHOBTB2 GTPASE CYCLE	23	2.11e-01	-0.151000	4.12e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	1.76e-01	-0.150000	3.69e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	607	3.12e-10	-0.150000	2.83e-08
METABOLISM OF NUCLEOTIDES	92	1.29e-02	-0.150000	6.51e-02
FCGR3A MEDIATED IL10 SYNTHESIS	32	1.42e-01	0.150000	3.21e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	3.15e-01	-0.150000	5.31e-01
MUCOPOLYSACCHARIDOSES	11	3.90e-01	0.150000	6.01e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	1.72e-01	-0.149000	3.63e-01
PRE NOTCH EXPRESSION AND PROCESSING	65	3.79e-02	0.149000	1.36e-01
HIV TRANSCRIPTION ELONGATION	42	9.50e-02	-0.149000	2.49e-01
GAP JUNCTION ASSEMBLY	21	2.39e-01	-0.148000	4.49e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	3.58e-01	0.147000	5.69e-01
NEGATIVE REGULATION OF MAPK PATHWAY	42	9.88e-02	-0.147000	2.54e-01
TRNA PROCESSING IN THE NUCLEUS	56	5.69e-02	-0.147000	1.78e-01
NICOTINATE METABOLISM	25	2.03e-01	-0.147000	4.07e-01
RA BIOSYNTHESIS PATHWAY	15	3.25e-01	-0.147000	5.38e-01
HSF1 ACTIVATION	26	1.95e-01	-0.147000	3.98e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	3.10e-01	-0.147000	5.27e-01
PURINE SALVAGE	12	3.80e-01	-0.146000	5.93e-01
CHROMATIN MODIFYING ENZYMES	221	1.85e-04	0.146000	1.95e-03
FRS MEDIATED FGFR1 SIGNALING	18	2.84e-01	-0.146000	5.02e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	352	2.99e-06	-0.145000	6.53e-05
RMTS METHYLATE HISTONE ARGININES	44	9.58e-02	0.145000	2.50e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	1.27e-01	0.145000	3.00e-01
FLT3 SIGNALING IN DISEASE	28	1.88e-01	0.144000	3.85e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	2.91e-01	-0.144000	5.10e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	3.35e-01	-0.144000	5.51e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	16	3.20e-01	-0.144000	5.33e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	8.63e-02	-0.143000	2.38e-01
INTERLEUKIN 6 FAMILY SIGNALING	20	2.68e-01	0.143000	4.84e-01
RET SIGNALING	37	1.33e-01	0.143000	3.08e-01
SIGNALING BY FGFR4 IN DISEASE	11	4.13e-01	-0.142000	6.23e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	73	3.57e-02	0.142000	1.30e-01
REGULATION OF IFNG SIGNALING	13	3.76e-01	-0.142000	5.89e-01
ASPARAGINE N LINKED GLYCOSYLATION	285	3.95e-05	-0.142000	5.48e-04
COLLAGEN FORMATION	81	2.83e-02	0.141000	1.13e-01
CELL CYCLE	594	4.98e-09	-0.141000	3.26e-07
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	2.64e-01	0.141000	4.78e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	1.07e-01	-0.141000	2.65e-01
NEUROTRANSMITTER RELEASE CYCLE	49	8.88e-02	0.141000	2.42e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	17	3.17e-01	0.140000	5.32e-01
RESOLUTION OF ABASIC SITES AP SITES	37	1.43e-01	-0.139000	3.22e-01
IRAK4 DEFICIENCY TLR2 4	15	3.53e-01	-0.139000	5.68e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	3.56e-01	0.138000	5.68e-01
TRANS GOLGI NETWORK VESICLE BUDDING	70	4.66e-02	-0.138000	1.56e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	3.28e-01	-0.137000	5.40e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	7.69e-02	0.137000	2.20e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	32	1.81e-01	-0.137000	3.77e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	3.76e-01	-0.137000	5.89e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	1.17e-01	-0.137000	2.85e-01
RNA POLYMERASE I TRANSCRIPTION	68	5.22e-02	-0.136000	1.68e-01
LONG TERM POTENTIATION	23	2.59e-01	0.136000	4.73e-01
HCMV LATE EVENTS	66	5.63e-02	-0.136000	1.77e-01
EXTENSION OF TELOMERES	49	1.01e-01	-0.135000	2.57e-01
CD209 DC SIGN SIGNALING	18	3.22e-01	-0.135000	5.35e-01
RHOV GTPASE CYCLE	33	1.80e-01	0.135000	3.76e-01
BIOTIN TRANSPORT AND METABOLISM	11	4.39e-01	0.135000	6.50e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	12	4.19e-01	-0.135000	6.30e-01
RESOLUTION OF SISTER CHROMATID COHESION	102	1.89e-02	-0.135000	8.53e-02
RHOU GTPASE CYCLE	34	1.75e-01	0.135000	3.67e-01
MRNA SPLICING MINOR PATHWAY	52	9.35e-02	-0.134000	2.46e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	2.11e-01	-0.134000	4.12e-01
INFECTIOUS DISEASE	737	6.98e-10	-0.134000	5.48e-08
INNATE IMMUNE SYSTEM	792	1.90e-10	-0.134000	1.87e-08
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	2.68e-01	0.134000	4.84e-01
PROTEIN FOLDING	89	2.99e-02	-0.133000	1.17e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	74	4.79e-02	-0.133000	1.59e-01
INTEGRIN SIGNALING	24	2.59e-01	0.133000	4.73e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	71	5.35e-02	-0.133000	1.71e-01
TP53 REGULATES METABOLIC GENES	87	3.35e-02	-0.132000	1.24e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	20	3.08e-01	-0.132000	5.24e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	290	1.17e-04	-0.132000	1.35e-03
DEADENYLATION DEPENDENT MRNA DECAY	55	9.13e-02	-0.132000	2.45e-01
EPHB MEDIATED FORWARD SIGNALING	42	1.41e-01	-0.131000	3.19e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	13	4.13e-01	-0.131000	6.23e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	18	3.36e-01	-0.131000	5.51e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	2.48e-01	0.131000	4.59e-01
PROLONGED ERK ACTIVATION EVENTS	14	3.97e-01	-0.131000	6.09e-01
AMYLOID FIBER FORMATION	58	8.52e-02	-0.131000	2.36e-01
TOLL LIKE RECEPTOR CASCADES	141	7.47e-03	-0.131000	4.23e-02
ONCOGENE INDUCED SENESCENCE	32	2.02e-01	0.130000	4.07e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	2.28e-01	-0.129000	4.35e-01
STIMULI SENSING CHANNELS	76	5.14e-02	0.129000	1.67e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	1.52e-01	0.129000	3.36e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	4.40e-01	0.129000	6.51e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	4.81e-01	0.129000	6.86e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	4.81e-01	0.129000	6.86e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	108	2.12e-02	0.128000	9.26e-02
PLATELET CALCIUM HOMEOSTASIS	26	2.60e-01	0.128000	4.74e-01
METABOLISM OF FAT SOLUBLE VITAMINS	33	2.05e-01	0.127000	4.07e-01
MEIOTIC RECOMBINATION	39	1.69e-01	-0.127000	3.61e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	56	1.01e-01	0.127000	2.57e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	553	3.81e-07	-0.127000	1.25e-05
FOXO MEDIATED TRANSCRIPTION	59	9.28e-02	-0.127000	2.46e-01
L1CAM INTERACTIONS	107	2.38e-02	0.127000	1.01e-01
REGULATION OF TNFR1 SIGNALING	34	2.02e-01	0.126000	4.07e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	22	3.07e-01	-0.126000	5.23e-01
SNRNP ASSEMBLY	51	1.20e-01	-0.126000	2.90e-01
EXTRACELLULAR MATRIX ORGANIZATION	247	6.86e-04	0.126000	6.18e-03
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	4.34e-01	0.125000	6.45e-01
PEXOPHAGY	11	4.73e-01	0.125000	6.82e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	22	3.10e-01	-0.125000	5.27e-01
METABOLISM OF AMINE DERIVED HORMONES	10	4.95e-01	0.125000	6.96e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	28	2.54e-01	-0.125000	4.66e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	48	1.35e-01	-0.125000	3.12e-01
RHO GTPASES ACTIVATE IQGAPS	24	2.91e-01	-0.125000	5.10e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	29	2.46e-01	0.124000	4.58e-01
PRC2 METHYLATES HISTONES AND DNA	30	2.39e-01	-0.124000	4.49e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	1.99e-01	-0.124000	4.03e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	14	4.24e-01	0.123000	6.33e-01
AUTOPHAGY	140	1.20e-02	-0.123000	6.16e-02
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	171	5.57e-03	-0.123000	3.39e-02
INWARDLY RECTIFYING K CHANNELS	32	2.30e-01	-0.123000	4.37e-01
SIGNALING BY FLT3 FUSION PROTEINS	19	3.58e-01	0.122000	5.69e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	5.06e-01	-0.121000	7.02e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	26	2.84e-01	-0.121000	5.02e-01
METABOLISM OF STEROID HORMONES	21	3.36e-01	-0.121000	5.51e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	179	5.22e-03	-0.121000	3.21e-02
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	64	9.53e-02	-0.121000	2.49e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	21	3.39e-01	-0.121000	5.52e-01
RHO GTPASES ACTIVATE PKNS	48	1.51e-01	-0.120000	3.36e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	2.73e-01	-0.120000	4.88e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	1.28e-01	0.120000	3.00e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	7.78e-02	-0.119000	2.21e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	94	4.56e-02	-0.119000	1.54e-01
P75NTR SIGNALS VIA NF KB	16	4.08e-01	0.119000	6.19e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	1.13e-01	-0.119000	2.77e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	53	1.34e-01	0.119000	3.10e-01
MITOTIC G2 G2 M PHASES	187	5.10e-03	-0.119000	3.18e-02
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	3.46e-01	-0.119000	5.60e-01
MTOR SIGNALLING	41	1.89e-01	-0.118000	3.87e-01
SIGNALING BY NOTCH1	75	7.63e-02	0.118000	2.18e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	27	2.87e-01	-0.118000	5.06e-01
SENSORY PERCEPTION	153	1.19e-02	0.118000	6.16e-02
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	62	1.09e-01	-0.118000	2.69e-01
INTERLEUKIN 17 SIGNALING	68	9.34e-02	-0.118000	2.46e-01
SIGNALING BY RETINOIC ACID	35	2.28e-01	-0.118000	4.35e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	1.42e-01	-0.118000	3.21e-01
NEURONAL SYSTEM	373	1.00e-04	0.118000	1.20e-03
INTERLEUKIN 1 FAMILY SIGNALING	123	2.47e-02	-0.117000	1.03e-01
REGULATION OF IFNA SIGNALING	12	4.82e-01	0.117000	6.86e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	4.82e-01	-0.117000	6.86e-01
HEME SIGNALING	46	1.69e-01	0.117000	3.61e-01
GENERATION OF SECOND MESSENGER MOLECULES	19	3.79e-01	-0.117000	5.91e-01
RHO GTPASES ACTIVATE PAKS	21	3.56e-01	0.116000	5.68e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	2.54e-01	-0.116000	4.67e-01
INTERLEUKIN 10 SIGNALING	19	3.81e-01	-0.116000	5.93e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	4.70e-01	0.116000	6.80e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	5.28e-01	0.115000	7.22e-01
NEGATIVE REGULATION OF FLT3	14	4.57e-01	0.115000	6.68e-01
GLUCONEOGENESIS	27	3.05e-01	-0.114000	5.23e-01
SIGNAL AMPLIFICATION	30	2.80e-01	-0.114000	4.97e-01
DNA METHYLATION	21	3.66e-01	-0.114000	5.78e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	3.68e-01	-0.113000	5.79e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	4.97e-01	-0.113000	6.97e-01
RHO GTPASES ACTIVATE FORMINS	118	3.36e-02	-0.113000	1.24e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	32	2.68e-01	0.113000	4.84e-01
TNF SIGNALING	43	2.00e-01	0.113000	4.05e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	97	5.52e-02	0.113000	1.75e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.00e-01	0.113000	7.00e-01
MYD88 INDEPENDENT TLR4 CASCADE	94	5.96e-02	-0.112000	1.84e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	142	2.09e-02	-0.112000	9.19e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	4.52e-01	0.112000	6.65e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	4.68e-01	0.112000	6.78e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	4.68e-01	0.112000	6.78e-01
TIE2 SIGNALING	17	4.24e-01	-0.112000	6.33e-01
TBC RABGAPS	43	2.04e-01	-0.112000	4.07e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	4.24e-01	0.112000	6.33e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	4.00e-01	0.112000	6.09e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	2.83e-01	0.112000	5.01e-01
O LINKED GLYCOSYLATION	88	7.11e-02	0.111000	2.08e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	3.17e-01	0.111000	5.32e-01
G ALPHA Z SIGNALLING EVENTS	44	2.04e-01	-0.111000	4.07e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	4.89e-01	-0.111000	6.92e-01
COHESIN LOADING ONTO CHROMATIN	10	5.45e-01	-0.111000	7.38e-01
ADAPTIVE IMMUNE SYSTEM	614	3.68e-06	-0.110000	7.75e-05
ACYL CHAIN REMODELLING OF PS	14	4.78e-01	-0.110000	6.86e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	53	1.68e-01	-0.110000	3.60e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	3.67e-01	0.109000	5.78e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1230	1.90e-10	-0.109000	1.87e-08
DNA REPAIR	292	1.47e-03	-0.108000	1.15e-02
ASSEMBLY OF THE HIV VIRION	16	4.55e-01	-0.108000	6.66e-01
LYSINE CATABOLISM	11	5.37e-01	0.108000	7.31e-01
INTEGRATION OF ENERGY METABOLISM	99	6.48e-02	0.107000	1.94e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	4.58e-01	-0.107000	6.70e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	140	2.89e-02	-0.107000	1.15e-01
ION HOMEOSTASIS	51	1.87e-01	0.107000	3.83e-01
GLUTAMATE AND GLUTAMINE METABOLISM	13	5.06e-01	0.107000	7.02e-01
TRNA PROCESSING	105	6.02e-02	-0.106000	1.84e-01
RHOH GTPASE CYCLE	37	2.64e-01	-0.106000	4.78e-01
ION CHANNEL TRANSPORT	144	2.83e-02	0.106000	1.13e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	22	3.92e-01	-0.105000	6.02e-01
DISEASES OF METABOLISM	200	1.10e-02	0.104000	5.79e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS	11	5.49e-01	0.104000	7.39e-01
BASE EXCISION REPAIR AP SITE FORMATION	30	3.23e-01	-0.104000	5.37e-01
PEPTIDE HORMONE METABOLISM	60	1.67e-01	-0.103000	3.58e-01
LYSOSOME VESICLE BIOGENESIS	33	3.06e-01	-0.103000	5.23e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	64	1.55e-01	-0.103000	3.40e-01
FLT3 SIGNALING	36	2.88e-01	0.102000	5.06e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	13	5.23e-01	0.102000	7.16e-01
SMOOTH MUSCLE CONTRACTION	33	3.09e-01	0.102000	5.26e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	4.29e-01	0.102000	6.38e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	4.94e-01	-0.102000	6.96e-01
PLATELET AGGREGATION PLUG FORMATION	32	3.19e-01	0.102000	5.32e-01
AQUAPORIN MEDIATED TRANSPORT	42	2.55e-01	-0.101000	4.68e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	4.21e-01	0.101000	6.32e-01
DISEASES OF DNA REPAIR	11	5.61e-01	0.101000	7.50e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	2.25e-01	-0.100000	4.30e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	21	4.27e-01	-0.100000	6.36e-01
UB SPECIFIC PROCESSING PROTEASES	169	2.47e-02	-0.100000	1.03e-01
HOMOLOGY DIRECTED REPAIR	107	7.44e-02	-0.099900	2.15e-01
CA DEPENDENT EVENTS	36	3.01e-01	0.099600	5.20e-01
PTEN REGULATION	136	4.55e-02	-0.099400	1.54e-01
NETRIN 1 SIGNALING	50	2.24e-01	0.099400	4.30e-01
COLLAGEN CHAIN TRIMERIZATION	41	2.72e-01	0.099100	4.87e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	4.80e-01	-0.099000	6.86e-01
PARASITE INFECTION	54	2.10e-01	-0.098600	4.11e-01
HEDGEHOG ON STATE	83	1.21e-01	-0.098400	2.92e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	64	1.74e-01	-0.098300	3.67e-01
SIGNALING BY INTERLEUKINS	353	1.55e-03	-0.098300	1.19e-02
P38MAPK EVENTS	13	5.41e-01	-0.097900	7.35e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	51	2.27e-01	0.097900	4.33e-01
MEIOSIS	66	1.71e-01	-0.097500	3.61e-01
ACYL CHAIN REMODELLING OF PC	17	4.87e-01	0.097400	6.90e-01
RHO GTPASE CYCLE	426	6.14e-04	0.097000	5.57e-03
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	27	3.84e-01	-0.096900	5.94e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	4.12e-01	-0.096700	6.23e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	94	1.06e-01	0.096600	2.65e-01
ELASTIC FIBRE FORMATION	38	3.04e-01	0.096300	5.23e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	5.48e-01	-0.096200	7.39e-01
ESR MEDIATED SIGNALING	168	3.17e-02	-0.096100	1.21e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	108	8.68e-02	0.095500	2.38e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	5.84e-01	0.095300	7.69e-01
PLASMA LIPOPROTEIN CLEARANCE	28	3.83e-01	0.095200	5.94e-01
REGULATION OF INSULIN SECRETION	71	1.69e-01	0.094400	3.61e-01
MRNA SPLICING	188	2.62e-02	-0.094100	1.07e-01
RHO GTPASES ACTIVATE CIT	18	4.91e-01	0.093800	6.94e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	109	9.12e-02	0.093700	2.45e-01
SIGNALING BY WNT	270	8.49e-03	-0.093200	4.66e-02
DEUBIQUITINATION	243	1.29e-02	-0.092800	6.51e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	29	3.88e-01	-0.092700	5.98e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	4.86e-01	-0.092300	6.90e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	3.99e-01	-0.092200	6.09e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	2.22e-01	0.091900	4.27e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	76	1.67e-01	-0.091800	3.58e-01
SIGNAL TRANSDUCTION BY L1	21	4.71e-01	-0.090900	6.80e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	95	1.28e-01	-0.090400	3.00e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	5.89e-01	0.090000	7.71e-01
APOPTOTIC EXECUTION PHASE	45	2.98e-01	-0.089800	5.18e-01
NONHOMOLOGOUS END JOINING NHEJ	44	3.04e-01	-0.089500	5.23e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	92	1.40e-01	-0.089100	3.19e-01
KERATAN SULFATE BIOSYNTHESIS	24	4.52e-01	-0.088600	6.65e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	4.02e-01	-0.088500	6.09e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	3.79e-01	-0.088400	5.92e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	5.82e-01	-0.088200	7.67e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	5.42e-01	-0.088100	7.35e-01
SARS COV INFECTIONS	141	7.14e-02	-0.088000	2.09e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	1.58e-01	-0.087700	3.45e-01
SIGNALING BY FGFR1	44	3.14e-01	-0.087700	5.31e-01
MEIOTIC SYNAPSIS	42	3.26e-01	-0.087600	5.39e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	6.00e-01	-0.087500	7.80e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	2.06e-02	-0.087500	9.08e-02
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	74	1.96e-01	0.086900	3.99e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	5.48e-01	-0.086700	7.39e-01
SIGNALING BY MET	74	2.04e-01	0.085500	4.07e-01
SELECTIVE AUTOPHAGY	73	2.08e-01	-0.085400	4.08e-01
DAP12 SIGNALING	24	4.70e-01	-0.085100	6.80e-01
FGFR2 ALTERNATIVE SPLICING	25	4.62e-01	-0.085000	6.73e-01
RHO GTPASES ACTIVATE ROCKS	19	5.23e-01	0.084700	7.16e-01
TRANSCRIPTIONAL REGULATION BY TP53	346	6.92e-03	-0.084700	4.02e-02
HYALURONAN UPTAKE AND DEGRADATION	12	6.13e-01	0.084300	7.86e-01
IRS MEDIATED SIGNALLING	40	3.58e-01	-0.084100	5.69e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	148	7.81e-02	-0.084000	2.21e-01
METABOLISM OF FOLATE AND PTERINES	15	5.74e-01	0.083900	7.61e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	3.16e-01	0.083700	5.31e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	3.74e-01	-0.083400	5.86e-01
SIGNALING BY FGFR IN DISEASE	57	2.78e-01	-0.083200	4.95e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	6.18e-01	-0.083100	7.88e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	24	4.82e-01	-0.082900	6.86e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	4.92e-01	0.082800	6.94e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	3.27e-01	-0.082700	5.39e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	5.03e-01	-0.082500	7.01e-01
RNA POLYMERASE II TRANSCRIPTION	1100	4.63e-06	-0.082400	8.67e-05
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	6.07e-01	-0.082300	7.83e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	3.20e-01	0.082200	5.33e-01
SIGNALING BY NTRKS	130	1.07e-01	-0.082000	2.65e-01
PECAM1 INTERACTIONS	12	6.24e-01	0.081700	7.92e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	4.47e-01	0.081600	6.59e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	2.89e-01	-0.081200	5.08e-01
HDACS DEACETYLATE HISTONES	47	3.36e-01	0.081100	5.51e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	91	1.82e-01	-0.081100	3.77e-01
DEATH RECEPTOR SIGNALLING	133	1.07e-01	0.081000	2.66e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	5.13e-01	-0.080500	7.08e-01
SIGNALING BY ERBB2	48	3.37e-01	-0.080100	5.51e-01
ERBB2 ACTIVATES PTK6 SIGNALING	11	6.47e-01	0.079800	8.11e-01
IRAK1 RECRUITS IKK COMPLEX	14	6.05e-01	0.079700	7.83e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	245	3.20e-02	0.079600	1.21e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	6.49e-01	0.079300	8.11e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	2.01e-01	-0.078900	4.05e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	6.66e-01	-0.078800	8.19e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	106	1.62e-01	-0.078600	3.52e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	3.84e-01	0.078600	5.94e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	45	3.63e-01	-0.078400	5.74e-01
SIGNALING BY NOTCH3	48	3.48e-01	0.078300	5.63e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	96	1.86e-01	-0.078100	3.83e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	2.52e-01	-0.078000	4.66e-01
HCMV INFECTION	104	1.70e-01	-0.078000	3.61e-01
METAL ION SLC TRANSPORTERS	25	5.00e-01	0.077900	7.00e-01
MYOGENESIS	25	5.03e-01	0.077300	7.01e-01
SIGNALING BY EGFR	47	3.59e-01	0.077300	5.70e-01
POLO LIKE KINASE MEDIATED EVENTS	14	6.17e-01	-0.077300	7.87e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	24	5.14e-01	-0.076900	7.09e-01
MHC CLASS II ANTIGEN PRESENTATION	101	1.83e-01	-0.076800	3.79e-01
CELL CELL JUNCTION ORGANIZATION	49	3.53e-01	-0.076800	5.68e-01
KERATAN SULFATE DEGRADATION	11	6.60e-01	0.076700	8.18e-01
G ALPHA S SIGNALLING EVENTS	108	1.69e-01	0.076600	3.61e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	6.47e-01	-0.076400	8.11e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	4.37e-01	-0.075900	6.48e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	93	2.08e-01	-0.075700	4.08e-01
SIGNALING BY NODAL	15	6.13e-01	-0.075500	7.86e-01
SHC MEDIATED CASCADE FGFR4	12	6.51e-01	-0.075400	8.12e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	5.63e-01	0.074700	7.52e-01
COMPLEMENT CASCADE	27	5.04e-01	0.074400	7.01e-01
SIGNALING BY TGFB FAMILY MEMBERS	97	2.09e-01	-0.073900	4.10e-01
KILLING MECHANISMS	11	6.72e-01	0.073700	8.24e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	5.44e-01	-0.073200	7.37e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	26	5.20e-01	0.072900	7.14e-01
SIGNALLING TO ERKS	34	4.63e-01	-0.072800	6.74e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	27	5.13e-01	-0.072700	7.08e-01
RHOBTB GTPASE CYCLE	35	4.59e-01	-0.072300	6.70e-01
PYRIMIDINE SALVAGE	10	6.93e-01	0.072200	8.36e-01
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION	10	6.93e-01	0.072100	8.36e-01
RHOJ GTPASE CYCLE	55	3.56e-01	0.072000	5.68e-01
HSF1 DEPENDENT TRANSACTIVATION	34	4.72e-01	0.071300	6.81e-01
MUSCLE CONTRACTION	164	1.18e-01	0.070800	2.85e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	195	8.87e-02	0.070800	2.42e-01
RAB REGULATION OF TRAFFICKING	118	1.85e-01	-0.070800	3.80e-01
PROLACTIN RECEPTOR SIGNALING	11	6.85e-01	-0.070600	8.31e-01
DEFECTS IN COBALAMIN B12 METABOLISM	13	6.60e-01	-0.070600	8.18e-01
CELLULAR RESPONSE TO HEAT STRESS	95	2.35e-01	-0.070500	4.44e-01
OTHER INTERLEUKIN SIGNALING	20	5.85e-01	0.070500	7.69e-01
SIGNALING BY EGFR IN CANCER	22	5.68e-01	-0.070300	7.57e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	27	5.34e-01	-0.069200	7.29e-01
VLDLR INTERNALISATION AND DEGRADATION	12	6.79e-01	0.069000	8.28e-01
SIGNALING BY NUCLEAR RECEPTORS	227	7.38e-02	-0.069000	2.14e-01
ENDOGENOUS STEROLS	20	5.95e-01	0.068600	7.76e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	5.96e-01	-0.068600	7.76e-01
GAP JUNCTION DEGRADATION	11	6.95e-01	-0.068200	8.38e-01
COLLAGEN DEGRADATION	51	4.00e-01	0.068100	6.09e-01
RAP1 SIGNALLING	15	6.48e-01	-0.068000	8.11e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	6.84e-01	-0.067900	8.31e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	2.98e-01	-0.067700	5.18e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	5.35e-01	-0.067700	7.29e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	36	4.82e-01	0.067700	6.86e-01
REDUCTION OF CYTOSOLIC CA LEVELS	12	6.85e-01	0.067600	8.31e-01
CILIUM ASSEMBLY	193	1.08e-01	0.067100	2.69e-01
RHO GTPASE EFFECTORS	252	6.81e-02	-0.066800	2.00e-01
SIGNALING BY FGFR	75	3.18e-01	-0.066700	5.32e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	4.55e-01	0.066600	6.66e-01
SIGNALING BY NOTCH2	33	5.08e-01	0.066600	7.04e-01
INSULIN RECEPTOR SIGNALLING CASCADE	45	4.40e-01	-0.066600	6.51e-01
VXPX CARGO TARGETING TO CILIUM	19	6.16e-01	0.066500	7.87e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	5.82e-01	-0.066300	7.67e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	6.10e-01	0.065900	7.86e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	6.51e-01	-0.065400	8.12e-01
TRP CHANNELS	20	6.13e-01	0.065300	7.86e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	14	6.73e-01	0.065200	8.25e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	4.53e-01	-0.064700	6.65e-01
SIGNALING BY FGFR2	64	3.71e-01	-0.064700	5.83e-01
RHOBTB1 GTPASE CYCLE	23	5.92e-01	-0.064500	7.73e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	5.70e-01	0.064400	7.58e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	5.54e-01	-0.063400	7.43e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	6.82e-01	0.063200	8.31e-01
POTASSIUM CHANNELS	91	2.98e-01	0.063100	5.18e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	7.19e-01	-0.062700	8.53e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	5.81e-01	0.062600	7.67e-01
ER QUALITY CONTROL COMPARTMENT ERQC	21	6.22e-01	-0.062200	7.91e-01
SIGNALING BY KIT IN DISEASE	20	6.31e-01	-0.062100	7.97e-01
OVARIAN TUMOR DOMAIN PROTEASES	37	5.15e-01	-0.061900	7.09e-01
GLYCOSAMINOGLYCAN METABOLISM	115	2.52e-01	0.061900	4.65e-01
PHOSPHOLIPID METABOLISM	187	1.52e-01	0.060800	3.36e-01
TRIGLYCERIDE BIOSYNTHESIS	10	7.39e-01	-0.060800	8.66e-01
VIRAL MESSENGER RNA SYNTHESIS	42	4.96e-01	-0.060700	6.97e-01
SIGNALING BY PDGF	57	4.28e-01	0.060700	6.37e-01
RHOQ GTPASE CYCLE	59	4.22e-01	0.060500	6.32e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	7.06e-01	0.060500	8.45e-01
REGULATION OF KIT SIGNALING	16	6.76e-01	0.060400	8.26e-01
CLATHRIN MEDIATED ENDOCYTOSIS	133	2.29e-01	-0.060400	4.36e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	62	4.12e-01	-0.060200	6.23e-01
SIGNALING BY BMP	25	6.03e-01	-0.060200	7.81e-01
GAB1 SIGNALOSOME	14	6.97e-01	0.060100	8.38e-01
REGULATED PROTEOLYSIS OF P75NTR	12	7.19e-01	0.060000	8.53e-01
SIGNALING BY GPCR	486	2.42e-02	0.059900	1.02e-01
ONCOGENIC MAPK SIGNALING	76	3.67e-01	0.059800	5.78e-01
VITAMIN B5 PANTOTHENATE METABOLISM	15	6.91e-01	-0.059300	8.35e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	7.34e-01	-0.059300	8.63e-01
KERATAN SULFATE KERATIN METABOLISM	30	5.75e-01	-0.059100	7.62e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	63	4.17e-01	-0.059100	6.27e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	26	6.02e-01	-0.059100	7.81e-01
ATTENUATION PHASE	24	6.17e-01	0.059000	7.87e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	4.81e-01	-0.058800	6.86e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	222	1.32e-01	-0.058700	3.07e-01
INTRAFLAGELLAR TRANSPORT	52	4.65e-01	0.058600	6.76e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	5.50e-01	-0.058300	7.39e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	70	3.99e-01	0.058300	6.09e-01
MITOTIC PROMETAPHASE	177	1.84e-01	-0.057900	3.80e-01
CARDIAC CONDUCTION	109	3.01e-01	0.057400	5.20e-01
DNA DOUBLE STRAND BREAK REPAIR	136	2.53e-01	-0.056900	4.66e-01
SIGNALING BY NTRK2 TRKB	24	6.30e-01	0.056800	7.97e-01
SPRY REGULATION OF FGF SIGNALING	16	6.97e-01	-0.056100	8.38e-01
MICRORNA MIRNA BIOGENESIS	24	6.36e-01	0.055900	8.00e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	6.66e-01	-0.055700	8.19e-01
METABOLISM OF LIPIDS	616	1.86e-02	-0.055700	8.46e-02
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	32	5.85e-01	-0.055700	7.69e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	6.74e-01	-0.055700	8.26e-01
AMINE LIGAND BINDING RECEPTORS	28	6.10e-01	0.055600	7.86e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	6.24e-01	-0.055600	7.92e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	11	7.50e-01	0.055600	8.73e-01
SYNDECAN INTERACTIONS	26	6.24e-01	0.055500	7.92e-01
RNA POLYMERASE III TRANSCRIPTION	41	5.41e-01	-0.055200	7.35e-01
PYRIMIDINE CATABOLISM	10	7.64e-01	-0.054900	8.83e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	6.49e-01	-0.054800	8.11e-01
BASIGIN INTERACTIONS	22	6.58e-01	-0.054500	8.17e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	38	5.64e-01	-0.054100	7.52e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	6.91e-01	-0.054100	8.35e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	6.63e-01	-0.053700	8.19e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	7.11e-01	0.053500	8.49e-01
ESTROGEN DEPENDENT GENE EXPRESSION	104	3.52e-01	-0.052900	5.68e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	7.42e-01	0.052800	8.67e-01
MEMBRANE TRAFFICKING	581	3.20e-02	-0.052200	1.21e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	16	7.20e-01	0.051700	8.53e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	6.02e-01	-0.051700	7.81e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	18	7.05e-01	-0.051500	8.45e-01
HATS ACETYLATE HISTONES	94	3.90e-01	0.051400	6.00e-01
MITOCHONDRIAL BIOGENESIS	93	4.01e-01	-0.050400	6.09e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	6.06e-01	0.050300	7.83e-01
METABOLISM OF STEROIDS	115	3.55e-01	0.050000	5.68e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	5.02e-01	-0.049700	7.01e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	6.63e-01	-0.049300	8.19e-01
CALNEXIN CALRETICULIN CYCLE	26	6.64e-01	-0.049200	8.19e-01
VESICLE MEDIATED TRANSPORT	614	4.16e-02	-0.048300	1.45e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	7.93e-01	-0.048000	9.01e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	104	3.99e-01	-0.047900	6.09e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	25	6.84e-01	0.047100	8.31e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	14	7.61e-01	0.046900	8.83e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	53	5.56e-01	0.046800	7.44e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	76	4.85e-01	-0.046300	6.89e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	7.20e-01	-0.046300	8.53e-01
RESOLUTION OF D LOOP STRUCTURES	30	6.64e-01	-0.045900	8.19e-01
PLASMA LIPOPROTEIN REMODELING	14	7.66e-01	0.045800	8.83e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	630	5.04e-02	0.045800	1.65e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	183	2.86e-01	0.045800	5.05e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	6.15e-01	0.045400	7.87e-01
NUCLEAR ENVELOPE BREAKDOWN	50	5.80e-01	-0.045300	7.66e-01
G PROTEIN ACTIVATION	22	7.15e-01	-0.045000	8.52e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	79	4.91e-01	0.044800	6.94e-01
SIGNALING BY CSF3 G CSF	29	6.78e-01	-0.044600	8.27e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	85	4.78e-01	0.044600	6.86e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	5.09e-01	-0.044400	7.04e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	7.99e-01	-0.044300	9.03e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	16	7.59e-01	0.044300	8.82e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	8.09e-01	0.044200	9.07e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	8.02e-01	-0.043700	9.04e-01
ERYTHROPOIETIN ACTIVATES RAS	13	7.85e-01	-0.043600	8.96e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	52	5.87e-01	-0.043600	7.70e-01
REPRODUCTION	79	5.05e-01	-0.043400	7.02e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	5.50e-01	-0.042900	7.39e-01
CA2 PATHWAY	58	5.74e-01	0.042700	7.61e-01
RAC3 GTPASE CYCLE	91	4.82e-01	0.042600	6.86e-01
O LINKED GLYCOSYLATION OF MUCINS	42	6.33e-01	-0.042600	7.98e-01
CELLULAR HEXOSE TRANSPORT	11	8.07e-01	0.042500	9.07e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	12	7.99e-01	0.042400	9.03e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	19	7.49e-01	0.042400	8.73e-01
MAPK FAMILY SIGNALING CASCADES	290	2.15e-01	-0.042400	4.18e-01
ACYL CHAIN REMODELLING OF PE	17	7.67e-01	-0.041500	8.83e-01
MAP2K AND MAPK ACTIVATION	36	6.68e-01	0.041300	8.21e-01
RND1 GTPASE CYCLE	38	6.62e-01	0.041100	8.19e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	286	2.39e-01	-0.040500	4.49e-01
PREGNENOLONE BIOSYNTHESIS	12	8.08e-01	-0.040500	9.07e-01
PLASMA LIPOPROTEIN ASSEMBLY	12	8.09e-01	0.040400	9.07e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	7.80e-01	0.040300	8.95e-01
DNA DOUBLE STRAND BREAK RESPONSE	53	6.12e-01	0.040200	7.86e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	6.53e-01	-0.039700	8.13e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT	11	8.20e-01	0.039600	9.11e-01
GLYCOGEN METABOLISM	25	7.33e-01	0.039400	8.63e-01
SIGNALLING TO RAS	20	7.62e-01	0.039100	8.83e-01
ADHERENS JUNCTIONS INTERACTIONS	30	7.12e-01	0.039000	8.49e-01
RAC2 GTPASE CYCLE	88	5.28e-01	0.038900	7.22e-01
EGFR DOWNREGULATION	28	7.22e-01	-0.038900	8.54e-01
JOSEPHIN DOMAIN DUBS	11	8.25e-01	-0.038500	9.12e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	8.33e-01	-0.038500	9.17e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	45	6.55e-01	0.038500	8.15e-01
SIGNALING BY FGFR1 IN DISEASE	33	7.04e-01	0.038300	8.44e-01
RHOD GTPASE CYCLE	51	6.38e-01	0.038100	8.01e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	7.26e-01	0.037600	8.58e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	5.48e-01	0.037500	7.39e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	181	3.87e-01	-0.037300	5.98e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	33	7.11e-01	-0.037300	8.49e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	86	5.51e-01	0.037200	7.39e-01
RETROGRADE NEUROTROPHIN SIGNALLING	14	8.10e-01	0.037200	9.07e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	7.34e-01	0.037100	8.63e-01
AURKA ACTIVATION BY TPX2	72	5.87e-01	0.037000	7.70e-01
SIGNALING BY VEGF	104	5.15e-01	-0.037000	7.09e-01
SODIUM CALCIUM EXCHANGERS	10	8.41e-01	-0.036700	9.20e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	47	6.65e-01	0.036500	8.19e-01
INTERLEUKIN 27 SIGNALING	10	8.42e-01	0.036500	9.20e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	23	7.62e-01	-0.036400	8.83e-01
TELOMERE EXTENSION BY TELOMERASE	22	7.69e-01	0.036100	8.85e-01
SCAVENGING BY CLASS A RECEPTORS	15	8.09e-01	-0.036100	9.07e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	8.37e-01	-0.035800	9.19e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	6.34e-01	0.035600	7.98e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	7.92e-01	-0.035000	9.01e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	5.90e-01	-0.034600	7.72e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	188	4.16e-01	0.034500	6.26e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	46	6.87e-01	-0.034400	8.32e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	8.44e-01	0.034200	9.21e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	8.45e-01	-0.034100	9.21e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	7.94e-01	-0.033700	9.02e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	8.15e-01	0.033700	9.08e-01
SIGNALING BY HEDGEHOG	142	5.00e-01	0.032800	7.00e-01
GABA RECEPTOR ACTIVATION	55	6.76e-01	-0.032600	8.26e-01
SIGNALING BY SCF KIT	41	7.20e-01	0.032400	8.53e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	7.65e-01	0.032100	8.83e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	103	5.74e-01	-0.032100	7.61e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	7.90e-01	0.032100	9.01e-01
SIGNALING BY ERBB2 IN CANCER	25	7.81e-01	-0.032100	8.95e-01
REPRESSION OF WNT TARGET GENES	14	8.36e-01	0.032000	9.19e-01
FANCONI ANEMIA PATHWAY	36	7.42e-01	-0.031700	8.68e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	8.14e-01	-0.031300	9.08e-01
SIGNALING BY HIPPO	20	8.11e-01	0.030900	9.07e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	7.82e-01	0.030800	8.95e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	42	7.31e-01	-0.030700	8.62e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	368	3.17e-01	-0.030400	5.32e-01
GLUCOSE METABOLISM	81	6.38e-01	-0.030300	8.01e-01
THE PHOTOTRANSDUCTION CASCADE	21	8.11e-01	0.030200	9.07e-01
SHC MEDIATED CASCADE FGFR3	13	8.51e-01	-0.030100	9.24e-01
SUMOYLATION	164	5.21e-01	-0.029100	7.15e-01
EPH EPHRIN SIGNALING	92	6.31e-01	-0.029000	7.97e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	286	4.00e-01	0.029000	6.09e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	8.47e-01	-0.028900	9.22e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	46	7.36e-01	-0.028800	8.64e-01
PI 3K CASCADE FGFR3	13	8.59e-01	0.028500	9.28e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	8.22e-01	-0.028400	9.11e-01
SIGNALING BY ERYTHROPOIETIN	24	8.15e-01	0.027600	9.08e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	30	7.97e-01	0.027200	9.02e-01
INSULIN PROCESSING	24	8.19e-01	-0.027100	9.10e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	8.77e-01	0.027000	9.41e-01
GPCR LIGAND BINDING	271	4.47e-01	0.026900	6.59e-01
AGGREPHAGY	35	7.91e-01	0.025900	9.01e-01
SURFACTANT METABOLISM	16	8.59e-01	-0.025600	9.28e-01
CELL JUNCTION ORGANIZATION	74	7.04e-01	-0.025600	8.44e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	7.72e-01	-0.025500	8.87e-01
REGULATION OF PTEN GENE TRANSCRIPTION	59	7.39e-01	-0.025100	8.66e-01
CIRCADIAN CLOCK	68	7.21e-01	0.025100	8.53e-01
ZINC TRANSPORTERS	16	8.63e-01	0.024900	9.30e-01
RHOF GTPASE CYCLE	41	7.83e-01	-0.024800	8.96e-01
LEISHMANIA INFECTION	199	5.51e-01	-0.024500	7.39e-01
METABOLISM OF VITAMINS AND COFACTORS	154	6.00e-01	-0.024500	7.80e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	8.24e-01	-0.024300	9.12e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	8.41e-01	0.024200	9.20e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	8.98e-01	-0.023400	9.51e-01
NUCLEAR IMPORT OF REV PROTEIN	32	8.19e-01	-0.023400	9.10e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	467	3.91e-01	-0.023200	6.01e-01
SIGNALING BY ACTIVIN	12	8.89e-01	-0.023200	9.45e-01
HDR THROUGH MMEJ ALT NHEJ	10	9.01e-01	-0.022700	9.51e-01
G ALPHA Q SIGNALLING EVENTS	157	6.25e-01	0.022600	7.92e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	8.84e-01	0.022500	9.44e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	8.15e-01	-0.022300	9.08e-01
RHOG GTPASE CYCLE	74	7.40e-01	0.022300	8.67e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	8.82e-01	-0.022200	9.43e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	91	7.17e-01	-0.022000	8.53e-01
VISUAL PHOTOTRANSDUCTION	61	7.67e-01	0.021900	8.83e-01
STRIATED MUSCLE CONTRACTION	28	8.41e-01	0.021900	9.20e-01
NUCLEOBASE CATABOLISM	31	8.34e-01	-0.021800	9.17e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	63	7.66e-01	-0.021700	8.83e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	8.65e-01	0.021500	9.30e-01
PEPTIDE LIGAND BINDING RECEPTORS	112	6.98e-01	0.021300	8.38e-01
G ALPHA I SIGNALLING EVENTS	205	6.04e-01	0.021000	7.82e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	93	7.27e-01	-0.021000	8.58e-01
PLATELET HOMEOSTASIS	78	7.53e-01	-0.020600	8.76e-01
GABA B RECEPTOR ACTIVATION	40	8.22e-01	0.020600	9.11e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	36	8.32e-01	-0.020400	9.17e-01
SIGNALING BY NOTCH	190	6.34e-01	-0.020100	7.98e-01
RECYCLING PATHWAY OF L1	40	8.28e-01	-0.019900	9.15e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	8.45e-01	-0.019600	9.21e-01
FRS MEDIATED FGFR4 SIGNALING	14	9.01e-01	-0.019200	9.51e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	8.57e-01	0.019000	9.27e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	8.50e-01	0.018800	9.24e-01
NUCLEOTIDE SALVAGE	21	8.82e-01	-0.018800	9.43e-01
SLC TRANSPORTER DISORDERS	77	7.81e-01	0.018300	8.95e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	8.87e-01	-0.017900	9.44e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	71	7.98e-01	-0.017600	9.03e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	9.14e-01	-0.017400	9.57e-01
CELL CELL COMMUNICATION	107	7.58e-01	0.017300	8.81e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	9.15e-01	0.017100	9.57e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	9.09e-01	0.017100	9.54e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	120	7.47e-01	0.017100	8.72e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	9.02e-01	-0.016800	9.51e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	8.56e-01	0.016400	9.27e-01
ACYL CHAIN REMODELLING OF PG	10	9.29e-01	-0.016300	9.64e-01
FRS MEDIATED FGFR3 SIGNALING	15	9.13e-01	0.016300	9.57e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	86	7.96e-01	0.016100	9.02e-01
REGULATION OF BETA CELL DEVELOPMENT	29	8.81e-01	0.016100	9.43e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	59	8.32e-01	-0.016000	9.17e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	9.04e-01	-0.016000	9.51e-01
DSCAM INTERACTIONS	11	9.29e-01	0.015600	9.64e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	45	8.57e-01	0.015500	9.27e-01
TRNA AMINOACYLATION	42	8.64e-01	-0.015300	9.30e-01
PI METABOLISM	79	8.15e-01	0.015300	9.08e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	9.04e-01	-0.015200	9.51e-01
REGULATION OF SIGNALING BY CBL	22	9.03e-01	0.015000	9.51e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	8.85e-01	-0.015000	9.44e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	8.75e-01	-0.015000	9.39e-01
SIGNALING BY FGFR4	33	8.82e-01	-0.014900	9.43e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	9.33e-01	-0.014600	9.66e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	14	9.26e-01	-0.014300	9.64e-01
SIGNALING BY FGFR3	35	8.84e-01	0.014200	9.44e-01
HEDGEHOG OFF STATE	107	8.02e-01	-0.014000	9.04e-01
GLYCOGEN STORAGE DISEASES	12	9.35e-01	-0.013700	9.67e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	9.09e-01	-0.013500	9.54e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	9.26e-01	-0.013400	9.64e-01
CELLULAR SENESCENCE	143	7.84e-01	-0.013300	8.96e-01
HS GAG BIOSYNTHESIS	30	9.01e-01	0.013100	9.51e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	9.42e-01	-0.012800	9.71e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	9.04e-01	0.012500	9.51e-01
DECTIN 2 FAMILY	10	9.47e-01	-0.012200	9.73e-01
HCMV EARLY EVENTS	81	8.50e-01	0.012100	9.24e-01
PI 3K CASCADE FGFR4	12	9.43e-01	-0.012000	9.72e-01
DEVELOPMENTAL BIOLOGY	832	5.77e-01	0.011400	7.63e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	8.63e-01	0.011200	9.30e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	7.95e-01	-0.011100	9.02e-01
GOLGI TO ER RETROGRADE TRANSPORT	119	8.40e-01	-0.010700	9.20e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	33	9.16e-01	0.010600	9.57e-01
HIV ELONGATION ARREST AND RECOVERY	32	9.18e-01	-0.010500	9.58e-01
SIGNALING BY PTK6	50	9.00e-01	-0.010300	9.51e-01
OXIDATIVE STRESS INDUCED SENESCENCE	79	8.86e-01	0.009330	9.44e-01
SIGNALING BY ERBB4	57	9.05e-01	-0.009170	9.51e-01
PI3K EVENTS IN ERBB2 SIGNALING	15	9.52e-01	-0.008990	9.74e-01
REGULATION OF TP53 ACTIVITY	154	8.53e-01	-0.008660	9.25e-01
REGULATION OF FZD BY UBIQUITINATION	19	9.49e-01	0.008550	9.73e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	9.15e-01	0.008520	9.57e-01
SIGNALING BY WNT IN CANCER	31	9.35e-01	0.008400	9.67e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	58	9.13e-01	-0.008310	9.57e-01
CARNITINE METABOLISM	14	9.57e-01	-0.008260	9.76e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	9.48e-01	0.007990	9.73e-01
GENE SILENCING BY RNA	83	9.02e-01	0.007810	9.51e-01
METABOLISM OF CARBOHYDRATES	261	8.29e-01	0.007800	9.15e-01
FCERI MEDIATED CA 2 MOBILIZATION	26	9.46e-01	-0.007690	9.73e-01
CGMP EFFECTS	15	9.60e-01	0.007530	9.77e-01
EPHRIN SIGNALING	19	9.55e-01	0.007490	9.75e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	9.50e-01	-0.006910	9.73e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	51	9.33e-01	-0.006850	9.66e-01
FORMATION OF THE CORNIFIED ENVELOPE	27	9.53e-01	0.006570	9.74e-01
KERATINIZATION	27	9.53e-01	0.006570	9.74e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	9.64e-01	-0.005880	9.79e-01
UNFOLDED PROTEIN RESPONSE UPR	85	9.26e-01	-0.005810	9.64e-01
NUCLEAR SIGNALING BY ERBB4	31	9.59e-01	0.005370	9.77e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	39	9.54e-01	0.005330	9.75e-01
INTEGRIN CELL SURFACE INTERACTIONS	74	9.39e-01	-0.005170	9.69e-01
PI3K AKT SIGNALING IN CANCER	90	9.33e-01	-0.005130	9.66e-01
ERBB2 REGULATES CELL MOTILITY	14	9.75e-01	-0.004890	9.88e-01
GLYCOLYSIS	67	9.48e-01	-0.004640	9.73e-01
TRANSPORT OF SMALL MOLECULES	590	8.71e-01	-0.003920	9.36e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	9.61e-01	-0.003650	9.78e-01
MITOTIC TELOPHASE CYTOKINESIS	13	9.83e-01	0.003400	9.91e-01
SIGNALING BY PDGFR IN DISEASE	20	9.80e-01	-0.003290	9.91e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	9.83e-01	0.003200	9.91e-01
INTRA GOLGI TRAFFIC	43	9.72e-01	-0.003090	9.87e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	35	9.75e-01	0.003010	9.88e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	9.80e-01	-0.002510	9.91e-01
HEMOSTASIS	475	9.28e-01	0.002420	9.64e-01
LDL CLEARANCE	16	9.88e-01	-0.002210	9.93e-01
OPIOID SIGNALLING	86	9.74e-01	0.002060	9.88e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	9.91e-01	-0.002030	9.95e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	9.85e-01	0.001850	9.92e-01
SYNTHESIS OF PC	27	9.88e-01	-0.001660	9.93e-01
POTENTIAL THERAPEUTICS FOR SARS	78	9.85e-01	-0.001220	9.92e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	9.94e-01	-0.001060	9.96e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	9.96e-01	-0.000916	9.96e-01
NOD1 2 SIGNALING PATHWAY	35	9.94e-01	0.000775	9.96e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	95	9.90e-01	0.000752	9.94e-01
NERVOUS SYSTEM DEVELOPMENT	554	9.82e-01	0.000548	9.91e-01
DISEASES OF IMMUNE SYSTEM	27	9.96e-01	-0.000495	9.96e-01

---

Detailed Gene set reports

ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN

set	ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
setSize	10
pANOVA	0.00014
s.dist	-0.695
p.adjustANOVA	0.00153

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Aqp1	-8402
Hbb-bt	-8024
Cyb5r4	-7595
Car4	-6820
Hba-a1	-6349
Cyb5r2	-6138
Cyb5r1	-5445
Hba-a2	-5284
Car2	-4740
Cyb5rl	1430

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Aqp1	-8402
Hbb-bt	-8024
Cyb5r4	-7595
Car4	-6820
Hba-a1	-6349
Cyb5r2	-6138
Cyb5r1	-5445
Hba-a2	-5284
Car2	-4740
Cyb5rl	1430

---

ADENYLATE CYCLASE ACTIVATING PATHWAY

set	ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize	10
pANOVA	0.000193
s.dist	0.681
p.adjustANOVA	0.00202

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy6	8809
Adcy4	8797
Adcy5	7463
Adcy8	7208
Adcy2	6109
Adcy9	5538
Adcy3	5526
Adcy7	5405
Gnal	4618
Adcy1	3289

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy6	8809
Adcy4	8797
Adcy5	7463
Adcy8	7208
Adcy2	6109
Adcy9	5538
Adcy3	5526
Adcy7	5405
Gnal	4618
Adcy1	3289

---

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

set	REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize	17
pANOVA	6.28e-05
s.dist	0.561
p.adjustANOVA	0.000805

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ago3	8740
Tnrc6b	8728
Ago2	8315
Tnrc6a	8109
Ptpn11	7390
Mov10	7387
Ago1	6864
Pml	6837
Cdk6	6630
Ago4	5783
Runx1	5576
Src	5454
Tnrc6c	5160
Ccnd2	3374
Ccnd3	2219
Cbfb	-2844
Ccnd1	-4879

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ago3	8740
Tnrc6b	8728
Ago2	8315
Tnrc6a	8109
Ptpn11	7390
Mov10	7387
Ago1	6864
Pml	6837
Cdk6	6630
Ago4	5783
Runx1	5576
Src	5454
Tnrc6c	5160
Ccnd2	3374
Ccnd3	2219
Cbfb	-2844
Ccnd1	-4879

---

ENDOSOMAL VACUOLAR PATHWAY

set	ENDOSOMAL VACUOLAR PATHWAY
setSize	10
pANOVA	0.00387
s.dist	-0.527
p.adjustANOVA	0.0255

Top enriched genes

Top 20 genes

GeneID	Gene Rank
H2-T23	-7997
B2m	-7327
H2-M3	-6896
Ctsl	-6233
Ctss	-5908
H2-D1	-5834
H2-Q7	-4561
H2-Q2	-3155
H2-Q10	706
Lnpep	4490

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
H2-T23	-7997
B2m	-7327
H2-M3	-6896
Ctsl	-6233
Ctss	-5908
H2-D1	-5834
H2-Q7	-4561
H2-Q2	-3155
H2-Q10	706
Lnpep	4490

---

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

set	TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize	11
pANOVA	0.00282
s.dist	-0.52
p.adjustANOVA	0.0197

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Tlr3	-7488
Hsp90b1	-6978
Lgmn	-6720
Ctsl	-6233
Ctss	-5908
Ctsb	-5446
Tlr7	-3911
Cnpy3	-3430
Ctsk	-2448
Unc93b1	-991
Tlr9	3278

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Tlr3	-7488
Hsp90b1	-6978
Lgmn	-6720
Ctsl	-6233
Ctss	-5908
Ctsb	-5446
Tlr7	-3911
Cnpy3	-3430
Ctsk	-2448
Unc93b1	-991
Tlr9	3278

---

INTERACTION BETWEEN L1 AND ANKYRINS

set	INTERACTION BETWEEN L1 AND ANKYRINS
setSize	27
pANOVA	4.31e-06
s.dist	0.511
p.adjustANOVA	8.47e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sptbn4	9031
Nfasc	8963
Kcnq2	8538
Sptbn5	8500
Ank2	8456
Scn8a	8239
Ank3	7705
Sptb	6946
Sptan1	6805
Sptbn2	6785
Ank1	6711
Sptbn1	6660
L1cam	6562
Scn5a	6455
Scn2b	6184
Scn9a	5421
Scn7a	3990
Nrcam	3476
Scn4b	3460
Scn3a	3402

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sptbn4	9031
Nfasc	8963
Kcnq2	8538
Sptbn5	8500
Ank2	8456
Scn8a	8239
Ank3	7705
Sptb	6946
Sptan1	6805
Sptbn2	6785
Ank1	6711
Sptbn1	6660
L1cam	6562
Scn5a	6455
Scn2b	6184
Scn9a	5421
Scn7a	3990
Nrcam	3476
Scn4b	3460
Scn3a	3402
Scn2a	2479
Scn3b	2231
Kcnq3	2110
Scn1a	1588
Scn1b	-2546
Actb	-2633
Actg1	-6189

---

RETINOID CYCLE DISEASE EVENTS

set	RETINOID CYCLE DISEASE EVENTS
setSize	10
pANOVA	0.00737
s.dist	-0.489
p.adjustANOVA	0.0421

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Stra6	-8226
Abca4	-8164
Ttr	-7409
Rdh5	-6237
Napepld	-5216
Rdh12	-5024
Rbp1	-3620
Lrat	787
Rlbp1	1486
Rbp4	2233

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Stra6	-8226
Abca4	-8164
Ttr	-7409
Rdh5	-6237
Napepld	-5216
Rdh12	-5024
Rbp1	-3620
Lrat	787
Rlbp1	1486
Rbp4	2233

---

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

set	SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize	29
pANOVA	6.36e-06
s.dist	-0.484
p.adjustANOVA	0.000112

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8222
Ube2q2	-8179
Uchl3	-8039
Ube2e1	-7974
Ube2b	-7943
Ube2a	-7922
Ube2l3	-7832
Ube2k	-7806
Ube2d2a	-7702
Ube2r2	-5536
Ube2s	-4655
Otulin	-4527
Cdc34	-4476
Ubb	-4225
Rps27a	-4128
Ube2t	-3532
Uba6	-3400

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8222
Ube2q2	-8179
Uchl3	-8039
Ube2e1	-7974
Ube2b	-7943
Ube2a	-7922
Ube2l3	-7832
Ube2k	-7806
Ube2d2a	-7702
Ube2r2	-5536
Ube2s	-4655
Otulin	-4527
Cdc34	-4476
Ubb	-4225
Rps27a	-4128
Ube2t	-3532
Uba6	-3400
Usp9x	-2429
Ube2z	-1186
Usp5	2236
Ube2h	2264
Ube2g2	2749
Usp7	2986
Ubc	3482
Uba52	3693
Uba1	4505

---

LGI ADAM INTERACTIONS

set	LGI ADAM INTERACTIONS
setSize	14
pANOVA	0.00276
s.dist	0.462
p.adjustANOVA	0.0195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adam22	8018
Cacng8	7876
Stx1b	7706
Adam11	7576
Lgi2	7210
Stx1a	6800
Cacng4	6483
Dlg4	6250
Cacng3	5236
Lgi3	4268
Cacng2	3171
Adam23	1642
Lgi4	-4760
Lgi1	-6342

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adam22	8018
Cacng8	7876
Stx1b	7706
Adam11	7576
Lgi2	7210
Stx1a	6800
Cacng4	6483
Dlg4	6250
Cacng3	5236
Lgi3	4268
Cacng2	3171
Adam23	1642
Lgi4	-4760
Lgi1	-6342

---

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

set	YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
setSize	11
pANOVA	0.00994
s.dist	0.449
p.adjustANOVA	0.0535

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Hipk2	8828
Tead2	8494
Tead3	8235
Hipk1	7694
Tead1	7229
Yap1	6640
Runx2	6582
Tead4	1793
Ccn2	1408
Wwtr1	-2222
Kat2b	-7902

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Hipk2	8828
Tead2	8494
Tead3	8235
Hipk1	7694
Tead1	7229
Yap1	6640
Runx2	6582
Tead4	1793
Ccn2	1408
Wwtr1	-2222
Kat2b	-7902

---

CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT

set	CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
setSize	20
pANOVA	0.000515
s.dist	-0.449
p.adjustANOVA	0.0048

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atad1	-8342
Pex3	-8049
Slc25a17	-7801
Acbd5	-7620
Pex13	-7517
Abcd2	-7514
Pex2	-7321
Gdap1	-6704
Pex11b	-6362
Abcd3	-3438
Aldh3a2	-3316
Pex19	-2656
Pex14	-2366
Fis1	-2134
Pxmp4	-1092
Pxmp2	-1007
Pex12	172
Pex16	962
Pex26	2536
Abcd1	7957

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atad1	-8342
Pex3	-8049
Slc25a17	-7801
Acbd5	-7620
Pex13	-7517
Abcd2	-7514
Pex2	-7321
Gdap1	-6704
Pex11b	-6362
Abcd3	-3438
Aldh3a2	-3316
Pex19	-2656
Pex14	-2366
Fis1	-2134
Pxmp4	-1092
Pxmp2	-1007
Pex12	172
Pex16	962
Pex26	2536
Abcd1	7957

---

P75NTR REGULATES AXONOGENESIS

set	P75NTR REGULATES AXONOGENESIS
setSize	10
pANOVA	0.0152
s.dist	-0.443
p.adjustANOVA	0.0735

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Omg	-7629
Rhoa	-7528
Mcf2	-7460
Rtn4	-6580
Rtn4r	-6460
Ngf	-5443
Mag	-1771
Lingo1	-243
Arhgdia	2867
Ngfr	4878

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Omg	-7629
Rhoa	-7528
Mcf2	-7460
Rtn4	-6580
Rtn4r	-6460
Ngf	-5443
Mag	-1771
Lingo1	-243
Arhgdia	2867
Ngfr	4878

---

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

set	PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
setSize	11
pANOVA	0.0115
s.dist	0.44
p.adjustANOVA	0.0603

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cacna1b	8240
Cacna1e	7555
Cacna1a	6709
Cacnb3	6684
Cacng4	6483
Cacnb1	6156
Cacna2d2	5812
Cacng2	3171
Cacnb2	927
Cacna2d3	425
Cacnb4	-6238

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cacna1b	8240
Cacna1e	7555
Cacna1a	6709
Cacnb3	6684
Cacng4	6483
Cacnb1	6156
Cacna2d2	5812
Cacng2	3171
Cacnb2	927
Cacna2d3	425
Cacnb4	-6238

---

THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION

set	THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION
setSize	15
pANOVA	0.00317
s.dist	-0.44
p.adjustANOVA	0.0214

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Stra6	-8226
Abca4	-8164
Ttr	-7409
Rdh11	-6942
Cyp4v3	-6543
Rdh5	-6237
Napepld	-5216
Rdh12	-5024
Rbp1	-3620
Rdh10	-2642
Rdh1	-349
Lrat	787
Rlbp1	1486
Rbp4	2233
Myo7a	3262

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Stra6	-8226
Abca4	-8164
Ttr	-7409
Rdh11	-6942
Cyp4v3	-6543
Rdh5	-6237
Napepld	-5216
Rdh12	-5024
Rbp1	-3620
Rdh10	-2642
Rdh1	-349
Lrat	787
Rlbp1	1486
Rbp4	2233
Myo7a	3262

---

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

set	DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
setSize	20
pANOVA	0.00112
s.dist	0.421
p.adjustANOVA	0.00917

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cspg4	8445
Ncan	8142
Gpc2	8056
Sdc4	7952
Agrn	7775
Bcan	7332
Gpc4	6872
Gpc3	5372
Sdc3	4440
Hspg2	4414
Gpc1	4373
Bgn	4061
Vcan	4055
B4galt7	3015
Gpc6	1264
Dcn	238
Sdc1	-59
Gpc5	-316
Cspg5	-584
Sdc2	-4728

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cspg4	8445
Ncan	8142
Gpc2	8056
Sdc4	7952
Agrn	7775
Bcan	7332
Gpc4	6872
Gpc3	5372
Sdc3	4440
Hspg2	4414
Gpc1	4373
Bgn	4061
Vcan	4055
B4galt7	3015
Gpc6	1264
Dcn	238
Sdc1	-59
Gpc5	-316
Cspg5	-584
Sdc2	-4728

---

CD28 DEPENDENT VAV1 PATHWAY

set	CD28 DEPENDENT VAV1 PATHWAY
setSize	11
pANOVA	0.0175
s.dist	-0.414
p.adjustANOVA	0.0814

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cdc42	-8021
Rac1	-7232
Pak1	-7057
Cd86	-6182
Pak2	-4852
Pak3	-3904
Vav1	-3342
Grb2	-3247
Fyn	-777
Lck	2495
Cd80	6043

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cdc42	-8021
Rac1	-7232
Pak1	-7057
Cd86	-6182
Pak2	-4852
Pak3	-3904
Vav1	-3342
Grb2	-3247
Fyn	-777
Lck	2495
Cd80	6043

---

RORA ACTIVATES GENE EXPRESSION

set	RORA ACTIVATES GENE EXPRESSION
setSize	18
pANOVA	0.00257
s.dist	0.41
p.adjustANOVA	0.0185

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Crebbp	8606
Rxra	8090
Srebf1	7995
Chd9	7489
Med1	6811
Helz2	6452
Carm1	6321
Ncoa6	5922
Ep300	4552
Ncoa1	4448
Ppara	4348
Cpt1a	2883
Ncoa2	2551
Smarcd3	1706
Tbl1x	329
Tgs1	-1320
Rora	-2368
Tbl1xr1	-4338

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Crebbp	8606
Rxra	8090
Srebf1	7995
Chd9	7489
Med1	6811
Helz2	6452
Carm1	6321
Ncoa6	5922
Ep300	4552
Ncoa1	4448
Ppara	4348
Cpt1a	2883
Ncoa2	2551
Smarcd3	1706
Tbl1x	329
Tgs1	-1320
Rora	-2368
Tbl1xr1	-4338

---

MITOCHONDRIAL TRANSLATION

set	MITOCHONDRIAL TRANSLATION
setSize	93
pANOVA	1.3e-11
s.dist	-0.406
p.adjustANOVA	2.56e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Mrpl1	-8372
Mrpl50	-8312
Mrpl16	-8171
Mrps30	-8053
Mrps31	-7988
Mrpl10	-7857
Mrpl40	-7782
Mrps22	-7549
Mrpl3	-7512
Mrpl32	-7227
Mrps23	-7169
Mrpl47	-7049
Mrpl22	-6889
Mrps2	-6768
Mrps14	-6370
Mrpl17	-6224
Mrpl15	-5891
Mrpl13	-5815
Mrpl34	-5626
Ptcd3	-5531

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Mrpl1	-8372
Mrpl50	-8312
Mrpl16	-8171
Mrps30	-8053
Mrps31	-7988
Mrpl10	-7857
Mrpl40	-7782
Mrps22	-7549
Mrpl3	-7512
Mrpl32	-7227
Mrps23	-7169
Mrpl47	-7049
Mrpl22	-6889
Mrps2	-6768
Mrps14	-6370
Mrpl17	-6224
Mrpl15	-5891
Mrpl13	-5815
Mrpl34	-5626
Ptcd3	-5531
Mrpl30	-5477
Mrpl49	-5417
Mrpl27	-5406
Mrpl57	-5307
Chchd1	-5289
Mrpl42	-5160
Mrps18c	-5116
Mrpl48	-5078
Mrpl33	-5056
Mrpl39	-5006
Mrpl11	-4962
Mrpl9	-4957
Mtif2	-4876
Mrpl46	-4661
Mrps36	-4597
Mrps17	-4529
Oxa1l	-4517
Mrrf	-4425
Tsfm	-4312
Mrps33	-4137
Mrps27	-3961
Mrps18b	-3863
Mrpl44	-3832
Mtif3	-3817
Mrpl18	-3705
Gadd45gip1	-3621
Mrpl54	-3562
Mrps26	-3551
Mrps10	-3549
Mrps28	-3444
Mrpl28	-3319
Mrpl43	-3308
Mrps18a	-3230
Mrpl12	-3220
Mrpl20	-3209
Mrpl19	-3159
Mrps16	-3114
Mrpl51	-3048
Mrps25	-3040
Mrpl21	-2963
Mrps15	-2952
Mrpl52	-2885
Mrpl35	-2865
Mrps12	-2694
Mrpl2	-2585
Mrps7	-2518
Mrps9	-2492
Mrps24	-2227
Mrpl23	-2051
Mrpl41	-2001
Mrpl53	-1942
Mrpl55	-1658
Mrpl58	-1629
Mrpl24	-1574
Mrpl36	-1431
Mrps21	-804
Mrpl14	-667
Mrps5	-163
Mrps11	-100
Mrps34	385
Aurkaip1	386
Mrpl37	404
Mrps6	686
Mrps35	1578
Mrpl38	2987
Eral1	3187
Gfm1	3945
Tufm	4209
Mtfmt	5094
Dap3	5543
Mtrf1l	5673
Mrpl4	5962
Gfm2	7014

---

RECEPTOR MEDIATED MITOPHAGY

set	RECEPTOR MEDIATED MITOPHAGY
setSize	11
pANOVA	0.02
s.dist	-0.405
p.adjustANOVA	0.0887

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atg12	-8206
Fundc1	-8010
Atg5	-7838
Pgam5	-6809
Csnk2a2	-5328
Map1lc3b	-4664
Csnk2b	-4350
Csnk2a1	-2185
Map1lc3a	-854
Src	5454
Ulk1	7557

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atg12	-8206
Fundc1	-8010
Atg5	-7838
Pgam5	-6809
Csnk2a2	-5328
Map1lc3b	-4664
Csnk2b	-4350
Csnk2a1	-2185
Map1lc3a	-854
Src	5454
Ulk1	7557

---

CRISTAE FORMATION

set	CRISTAE FORMATION
setSize	31
pANOVA	0.000103
s.dist	-0.403
p.adjustANOVA	0.00122

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Apoo	-8140
Atp5c1	-8077
Mtx2	-8035
Atp5pb	-7500
Dmac2l	-7279
Mtx1	-5733
Apool	-5528
mt-Atp6	-5074
Atp5b	-4889
Atp5h	-4816
Atp5o	-4702
Atp5l	-4688
Chchd3	-4641
Atp5a1	-4506
Atp5g3	-4462
Immt	-3538
Tmem11	-3475
Hspa9	-3344
Chchd6	-3300
Micos10	-3150

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Apoo	-8140
Atp5c1	-8077
Mtx2	-8035
Atp5pb	-7500
Dmac2l	-7279
Mtx1	-5733
Apool	-5528
mt-Atp6	-5074
Atp5b	-4889
Atp5h	-4816
Atp5o	-4702
Atp5l	-4688
Chchd3	-4641
Atp5a1	-4506
Atp5g3	-4462
Immt	-3538
Tmem11	-3475
Hspa9	-3344
Chchd6	-3300
Micos10	-3150
Atp5g2	-3063
Micos13	-2577
Atp5j2	-1522
Atp5e	-1120
Atp5j	-1104
Atp5d	320
Samm50	900
Atp5g1	1350
Atp5k	2052
Dnajc11	3710
mt-Atp8	7356

---

BRANCHED CHAIN AMINO ACID CATABOLISM

set	BRANCHED CHAIN AMINO ACID CATABOLISM
setSize	21
pANOVA	0.00153
s.dist	-0.399
p.adjustANOVA	0.0119

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Dld	-8191
Acat1	-7990
Hibadh	-7680
Acad8	-7621
Mccc2	-6939
Bckdhb	-6749
Echs1	-6635
Aldh6a1	-6447
Hibch	-5886
Acadsb	-5538
Ppm1k	-5383
Auh	-5365
Dbt	-4513
Hsd17b10	-4468
Bckdk	-4357
Bckdha	779
Slc25a44	3737
Bcat1	5069
Bcat2	5467
Ivd	5522

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Dld	-8191
Acat1	-7990
Hibadh	-7680
Acad8	-7621
Mccc2	-6939
Bckdhb	-6749
Echs1	-6635
Aldh6a1	-6447
Hibch	-5886
Acadsb	-5538
Ppm1k	-5383
Auh	-5365
Dbt	-4513
Hsd17b10	-4468
Bckdk	-4357
Bckdha	779
Slc25a44	3737
Bcat1	5069
Bcat2	5467
Ivd	5522
Mccc1	7001

---

METABOLISM OF POLYAMINES

set	METABOLISM OF POLYAMINES
setSize	58
pANOVA	1.57e-07
s.dist	-0.398
p.adjustANOVA	5.98e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Nqo1	-7893
Psmd12	-7879
Psmb9	-7863
Sms	-7763
Amd1	-7588
Psma6	-7581
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Azin1	-6577
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Paox	-5469
Psmb7	-5402

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Nqo1	-7893
Psmd12	-7879
Psmb9	-7863
Sms	-7763
Amd1	-7588
Psma6	-7581
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Azin1	-6577
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Paox	-5469
Psmb7	-5402
Psmc2	-5067
Psma4	-4819
Psmd5	-4607
Psmb3	-4594
Psma3	-4521
Srm	-4337
Odc1	-4333
Sat1	-4129
Psme2	-4125
Psma7	-3984
Oaz2	-3958
Psma8	-3888
Psmd9	-3336
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Oaz1	-1521
Psmb4	-1485
Azin2	-406
Psmd11	-127
Psmc4	123
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Agmat	1870
Psmd4	2249
Psmd3	2920
Psmd2	3352
Psme4	3592
Oaz3	6302
Smox	8843

---

PENTOSE PHOSPHATE PATHWAY

set	PENTOSE PHOSPHATE PATHWAY
setSize	13
pANOVA	0.013
s.dist	-0.398
p.adjustANOVA	0.0651

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Prps2	-8270
Rpe	-7877
Rbks	-7613
Taldo1	-6866
Pgm2	-6624
Prps1	-4910
Shpk	-2540
G6pdx	-1634
Tkt	-961
Pgls	-216
Dera	1613
Pgd	1851
Rpia	3209

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Prps2	-8270
Rpe	-7877
Rbks	-7613
Taldo1	-6866
Pgm2	-6624
Prps1	-4910
Shpk	-2540
G6pdx	-1634
Tkt	-961
Pgls	-216
Dera	1613
Pgd	1851
Rpia	3209

---

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

set	COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize	26
pANOVA	0.000445
s.dist	-0.398
p.adjustANOVA	0.00427

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Vbp1	-8262
Cct6a	-7954
Tuba1c	-7928
Cct4	-7433
Pfdn4	-7391
Tcp1	-7384
Cct2	-6967
Cct5	-5869
Cct7	-5850
Cct8	-5470
Tuba8	-4992
Tuba1b	-4442
Pfdn1	-4323
Tuba4a	-3804
Cct3	-2880
Tubb4b	-2643
Actb	-2633
Pfdn5	-2074
Tuba1a	-1730
Pfdn6	-1535

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Vbp1	-8262
Cct6a	-7954
Tuba1c	-7928
Cct4	-7433
Pfdn4	-7391
Tcp1	-7384
Cct2	-6967
Cct5	-5869
Cct7	-5850
Cct8	-5470
Tuba8	-4992
Tuba1b	-4442
Pfdn1	-4323
Tuba4a	-3804
Cct3	-2880
Tubb4b	-2643
Actb	-2633
Pfdn5	-2074
Tuba1a	-1730
Pfdn6	-1535
Tubb3	484
Tubb2a	880
Pfdn2	4040
Tubb2b	4301
Tubb4a	4736
Tubb6	5553

---

NEGATIVE REGULATION OF NOTCH4 SIGNALING

set	NEGATIVE REGULATION OF NOTCH4 SIGNALING
setSize	54
pANOVA	4.28e-07
s.dist	-0.398
p.adjustANOVA	1.33e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Skp1	-7765
Psma6	-7581
Cul1	-7451
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Ywhaz	-6973
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067
Psma4	-4819

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Skp1	-7765
Psma6	-7581
Cul1	-7451
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Ywhaz	-6973
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067
Psma4	-4819
Rbx1	-4731
Psmd5	-4607
Psmb3	-4594
Psma3	-4521
Fbxw7	-4345
Ubb	-4225
Rps27a	-4128
Psme2	-4125
Psma7	-3984
Psmd9	-3336
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Tacc3	-1590
Psmc5	-1557
Psmb4	-1485
Psmd11	-127
Psmc4	123
Akt1	441
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Ubc	3482
Uba52	3693
Notch4	8970

---

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

set	FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize	19
pANOVA	0.00278
s.dist	-0.396
p.adjustANOVA	0.0195

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cct6a	-7954
Tuba1c	-7928
Cct4	-7433
Tcp1	-7384
Cct2	-6967
Cct5	-5869
Cct7	-5850
Cct8	-5470
Tuba8	-4992
Tuba1b	-4442
Tuba4a	-3804
Cct3	-2880
Tubb4b	-2643
Tuba1a	-1730
Tubb3	484
Tubb2a	880
Tubb2b	4301
Tubb4a	4736
Tubb6	5553

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cct6a	-7954
Tuba1c	-7928
Cct4	-7433
Tcp1	-7384
Cct2	-6967
Cct5	-5869
Cct7	-5850
Cct8	-5470
Tuba8	-4992
Tuba1b	-4442
Tuba4a	-3804
Cct3	-2880
Tubb4b	-2643
Tuba1a	-1730
Tubb3	484
Tubb2a	880
Tubb2b	4301
Tubb4a	4736
Tubb6	5553

---

ASSEMBLY OF THE PRE REPLICATIVE COMPLEX

set	ASSEMBLY OF THE PRE REPLICATIVE COMPLEX
setSize	65
pANOVA	3.26e-08
s.dist	-0.396
p.adjustANOVA	1.67e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Orc5	-7807
Orc6	-7774
Psma6	-7581
Orc4	-7372
Psma2	-7178
Psmd6	-7173
Mcm3	-7064
Psmf1	-7033
E2f2	-6977
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5507
Psmd10	-5498

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Orc5	-7807
Orc6	-7774
Psma6	-7581
Orc4	-7372
Psma2	-7178
Psmd6	-7173
Mcm3	-7064
Psmf1	-7033
E2f2	-6977
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067
Psma4	-4819
Psmd5	-4607
Psmb3	-4594
Psma3	-4521
Ubb	-4225
Rps27a	-4128
Psme2	-4125
E2f3	-4115
Mcm4	-4081
Psma7	-3984
Psma8	-3888
Mcm5	-3622
Psmd9	-3336
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Mcm8	-2254
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Psmb4	-1485
Orc3	-1298
Mcm6	-1096
Cdt1	-1095
Gmnn	-591
Psmd11	-127
Mcm2	-30
Psmc4	123
Mcm7	443
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Ubc	3482
Psme4	3592
Uba52	3693
E2f1	3871

---

SIGNALING BY LEPTIN

set	SIGNALING BY LEPTIN
setSize	10
pANOVA	0.0301
s.dist	0.396
p.adjustANOVA	0.117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sh2b1	8847
Stat3	7901
Ptpn11	7390
Stat5b	5597
Stat5a	4174
Irs1	3447
Irs2	3244
Socs3	2061
Jak2	-2191
Lepr	-2549

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sh2b1	8847
Stat3	7901
Ptpn11	7390
Stat5b	5597
Stat5a	4174
Irs1	3447
Irs2	3244
Socs3	2061
Jak2	-2191
Lepr	-2549

---

TIGHT JUNCTION INTERACTIONS

set	TIGHT JUNCTION INTERACTIONS
setSize	17
pANOVA	0.00473
s.dist	-0.396
p.adjustANOVA	0.0303

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cldn2	-8385
Cldn1	-7899
Cldn10	-7695
Crb3	-7194
Pals1	-6579
Cldn23	-4949
Pard6a	-4742
F11r	-4699
Cldn14	-3407
Cldn12	-2382
Cldn11	-2053
Pard6g	-1515
Prkci	-1137
Pard6b	-920
Cldn5	567
Patj	2872
Pard3	7069

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cldn2	-8385
Cldn1	-7899
Cldn10	-7695
Crb3	-7194
Pals1	-6579
Cldn23	-4949
Pard6a	-4742
F11r	-4699
Cldn14	-3407
Cldn12	-2382
Cldn11	-2053
Pard6g	-1515
Prkci	-1137
Pard6b	-920
Cldn5	567
Patj	2872
Pard3	7069

---

UNWINDING OF DNA

set	UNWINDING OF DNA
setSize	12
pANOVA	0.0185
s.dist	-0.393
p.adjustANOVA	0.0846

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gins4	-7426
Mcm3	-7064
Gins1	-6211
Mcm4	-4081
Mcm5	-3622
Cdc45	-3509
Mcm8	-2254
Gins2	-1941
Mcm6	-1096
Gins3	-341
Mcm2	-30
Mcm7	443

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gins4	-7426
Mcm3	-7064
Gins1	-6211
Mcm4	-4081
Mcm5	-3622
Cdc45	-3509
Mcm8	-2254
Gins2	-1941
Mcm6	-1096
Gins3	-341
Mcm2	-30
Mcm7	443

---

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

set	CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize	47
pANOVA	3.46e-06
s.dist	-0.391
p.adjustANOVA	7.43e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Psma6	-7581
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Fcgr1	-5384
Psmc2	-5067
Psma4	-4819
Psmd5	-4607
Psmb3	-4594

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Psma6	-7581
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Fcgr1	-5384
Psmc2	-5067
Psma4	-4819
Psmd5	-4607
Psmb3	-4594
Psma3	-4521
Psme2	-4125
Psma7	-3984
Psma8	-3888
Psmd9	-3336
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Psmb10	-2158
Mrc1	-1890
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Psmb4	-1485
Psmd11	-127
Psmc4	123
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Psme4	3592
Mrc2	7442

---

RESPIRATORY ELECTRON TRANSPORT

set	RESPIRATORY ELECTRON TRANSPORT
setSize	102
pANOVA	1e-11
s.dist	-0.39
p.adjustANOVA	2.36e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sco2	-8357
Ndufaf1	-7781
Ndufaf4	-7558
Coq10b	-7518
Ndufv2	-7288
Nubpl	-7181
Etfdh	-7138
mt-Nd2	-7058
Uqcrc2	-7011
Ndufc2	-6894
Cycs	-6846
Etfa	-6717
mt-Nd6	-6545
Uqcrfs1	-6297
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
Sdhb	-6076
mt-Nd1	-5998
Ndufaf2	-5957

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sco2	-8357
Ndufaf1	-7781
Ndufaf4	-7558
Coq10b	-7518
Ndufv2	-7288
Nubpl	-7181
Etfdh	-7138
mt-Nd2	-7058
Uqcrc2	-7011
Ndufc2	-6894
Cycs	-6846
Etfa	-6717
mt-Nd6	-6545
Uqcrfs1	-6297
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
Sdhb	-6076
mt-Nd1	-5998
Ndufaf2	-5957
mt-Nd5	-5921
Ndufb5	-5763
Ndufs1	-5654
mt-Co1	-5648
Sdhd	-5576
mt-Co2	-5540
mt-Cytb	-5503
Sco1	-5159
mt-Co3	-5132
Sdhc	-5051
Ndufb11	-4982
Cox7a2l	-4717
Ndufs8	-4554
Uqcrh	-4433
Ndufs3	-4362
Surf1	-4319
Ndufa10	-4303
Cox5a	-4292
Ndufab1	-4273
Ndufb4	-4258
Ndufb9	-4244
Ndufb3	-4242
Cyc1	-4099
Etfb	-4073
Ndufb8	-3926
Cox6b1	-3864
Ndufa4	-3840
Uqcrb	-3740
Ndufb6	-3356
Tmem126b	-3346
Cox7b	-3321
Cox16	-3259
Ndufa11	-3133
Ndufb10	-2957
Cox7c	-2948
Ecsit	-2886
Ndufa9	-2859
Ndufs5	-2850
Cox6a1	-2784
Cox14	-2706
Coq10a	-2702
Ndufa7	-2651
Ndufs2	-2592
Cox4i1	-2506
Ndufb2	-2482
Ndufc1	-2359
Cox11	-2221
Ndufa8	-1986
Uqcrc1	-1872
Cox20	-1724
Ndufv1	-1560
Ndufa2	-1533
Cox6c	-1400
Ndufa5	-1345
Uqcrq	-1295
Cox8a	-1269
Ndufaf3	-1246
Ndufb1	-1103
Cox18	-1099
Timmdc1	-816
Sdha	-746
Acad9	-691
Ndufb7	-650
Ndufa6	-561
Ndufa1	-470
Uqcr11	-114
mt-Nd3	257
Ndufaf6	359
Uqcr10	655
Taco1	754
Ndufs6	991
Cox5b	1154
Ndufv3	1180
Ndufa13	1624
Cox19	1643
Ndufa3	1809
Ndufaf7	1852
Ndufs7	1887
Lrpprc	2496
Ndufa12	3484
Trap1	4982
Tmem186	6998

---

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

set	SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize	13
pANOVA	0.0149
s.dist	-0.39
p.adjustANOVA	0.0724

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Spcs3	-7822
Pax6	-6309
Spcs2	-6276
Spcs1	-5475
Tcf7l2	-5465
Sec11c	-4613
Grp	-4264
Dpp4	-2463
Gng13	-1956
Pcsk1	-731
Sec11a	-585
Ctnnb1	1479
Gnb3	4562

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Spcs3	-7822
Pax6	-6309
Spcs2	-6276
Spcs1	-5475
Tcf7l2	-5465
Sec11c	-4613
Grp	-4264
Dpp4	-2463
Gng13	-1956
Pcsk1	-731
Sec11a	-585
Ctnnb1	1479
Gnb3	4562

---

PHOSPHORYLATION OF THE APC C

set	PHOSPHORYLATION OF THE APC C
setSize	18
pANOVA	0.00468
s.dist	-0.385
p.adjustANOVA	0.0302

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2d1	-8222
Ube2e1	-7974
Anapc10	-7448
Cdk1	-6990
Cdc26	-6730
Cdc16	-6482
Cdc27	-5034
Ube2s	-4655
Anapc7	-4523
Anapc16	-4039
Cdc23	-3460
Anapc4	-3101
Anapc15	-2461
Anapc11	-2259
Plk1	-337
Anapc1	5841
Anapc5	5967
Anapc2	7416

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2d1	-8222
Ube2e1	-7974
Anapc10	-7448
Cdk1	-6990
Cdc26	-6730
Cdc16	-6482
Cdc27	-5034
Ube2s	-4655
Anapc7	-4523
Anapc16	-4039
Cdc23	-3460
Anapc4	-3101
Anapc15	-2461
Anapc11	-2259
Plk1	-337
Anapc1	5841
Anapc5	5967
Anapc2	7416

---

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

set	ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize	20
pANOVA	0.00289
s.dist	-0.385
p.adjustANOVA	0.02

Top enriched genes

Top 20 genes

GeneID	Gene Rank
P2ry12	-8002
Gng10	-7643
Gng11	-6966
Gnai3	-6813
Gnai1	-6455
Gng2	-6301
Gnb4	-5817
Gnb5	-4612
Gnb2	-3583
Gng12	-3215
Gng5	-2767
Gng3	-2287
Gnai2	-2238
Gng13	-1956
Gng7	-1334
Gngt2	-973
Gnb1	-707
Gng8	1183
Gnb3	4562
Gng4	5430

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
P2ry12	-8002
Gng10	-7643
Gng11	-6966
Gnai3	-6813
Gnai1	-6455
Gng2	-6301
Gnb4	-5817
Gnb5	-4612
Gnb2	-3583
Gng12	-3215
Gng5	-2767
Gng3	-2287
Gnai2	-2238
Gng13	-1956
Gng7	-1334
Gngt2	-973
Gnb1	-707
Gng8	1183
Gnb3	4562
Gng4	5430

---

SYNAPTIC ADHESION LIKE MOLECULES

set	SYNAPTIC ADHESION LIKE MOLECULES
setSize	21
pANOVA	0.0023
s.dist	0.384
p.adjustANOVA	0.017

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ptprs	8611
Ptprf	8313
Grin2d	8049
Grin1	7427
Lrfn4	7358
Lrfn1	6939
Grin2b	6803
Dlg4	6250
Ptprd	6015
Flot2	5646
Lrfn3	5259
Grin2a	4973
Lrfn2	3931
Gria1	3628
Grin2c	2569
Flot1	2127
Gria4	716
Dlg3	-140
Gria3	-3700
Rtn3	-6403

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ptprs	8611
Ptprf	8313
Grin2d	8049
Grin1	7427
Lrfn4	7358
Lrfn1	6939
Grin2b	6803
Dlg4	6250
Ptprd	6015
Flot2	5646
Lrfn3	5259
Grin2a	4973
Lrfn2	3931
Gria1	3628
Grin2c	2569
Flot1	2127
Gria4	716
Dlg3	-140
Gria3	-3700
Rtn3	-6403
Dlg1	-6963

---

SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE

set	SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
setSize	87
pANOVA	7.63e-10
s.dist	-0.382
p.adjustANOVA	5.62e-08

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2d1	-8222
Ccne2	-8218
Psmc6	-8205
Ube2e1	-7974
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Orc5	-7807
Orc6	-7774
Skp1	-7765
Psma6	-7581
Cul1	-7451
Anapc10	-7448
Orc4	-7372
Psma2	-7178
Psmd6	-7173
Mcm3	-7064
Psmf1	-7033
Cdc26	-6730
Psma1	-6555

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2d1	-8222
Ccne2	-8218
Psmc6	-8205
Ube2e1	-7974
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Orc5	-7807
Orc6	-7774
Skp1	-7765
Psma6	-7581
Cul1	-7451
Anapc10	-7448
Orc4	-7372
Psma2	-7178
Psmd6	-7173
Mcm3	-7064
Psmf1	-7033
Cdc26	-6730
Psma1	-6555
Cdc16	-6482
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067
Cdc27	-5034
Psma4	-4819
Rbx1	-4731
Ube2s	-4655
Psmd5	-4607
Psmb3	-4594
Anapc7	-4523
Psma3	-4521
Ubb	-4225
Rps27a	-4128
Psme2	-4125
Mcm4	-4081
Anapc16	-4039
Psma7	-3984
Psma8	-3888
Ccne1	-3687
Mcm5	-3622
Cdc23	-3460
Psmd9	-3336
Anapc4	-3101
Anapc15	-2461
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Anapc11	-2259
Mcm8	-2254
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Psmb4	-1485
Orc3	-1298
Mcm6	-1096
Cdt1	-1095
Fzr1	-1003
Skp2	-450
Psmd11	-127
Mcm2	-30
Psmc4	123
Mcm7	443
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Ccna1	3448
Ubc	3482
Psme4	3592
Uba52	3693
Ccna2	5459
Anapc1	5841
Anapc5	5967
Cdk2	6754
Anapc2	7416

---

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

set	GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
setSize	31
pANOVA	0.000236
s.dist	-0.382
p.adjustANOVA	0.00244

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cdc42	-8021
Mtap	-7910
Gsto1	-7815
Rap1b	-7602
Tcp1	-7384
Capza1	-7277
Hnrnpdl	-6897
Taldo1	-6866
Rala	-5876
Arf1	-5535
Ppia	-5354
Pak2	-4852
Psme2	-4125
Rplp0	-3866
Hspa9	-3344
Cfl1	-3130
Pitpna	-3000
Pdcd4	-2817
Snrpa1	-2398
Aip	-2304

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cdc42	-8021
Mtap	-7910
Gsto1	-7815
Rap1b	-7602
Tcp1	-7384
Capza1	-7277
Hnrnpdl	-6897
Taldo1	-6866
Rala	-5876
Arf1	-5535
Ppia	-5354
Pak2	-4852
Psme2	-4125
Rplp0	-3866
Hspa9	-3344
Cfl1	-3130
Pitpna	-3000
Pdcd4	-2817
Snrpa1	-2398
Aip	-2304
Lcp1	-2085
Hnrnpf	-1008
Hnrnpa2b1	-975
Lmnb1	8
Bola2	324
Sod1	394
Sod2	1699
Mif	1967
Cnn2	2193
Msn	4112
Anxa2	6924

---

ADENYLATE CYCLASE INHIBITORY PATHWAY

set	ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize	13
pANOVA	0.0182
s.dist	0.378
p.adjustANOVA	0.0846

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy6	8809
Adcy4	8797
Adcy5	7463
Adcy8	7208
Adcy2	6109
Adcy9	5538
Adcy3	5526
Adcy7	5405
Gnal	4618
Adcy1	3289
Gnai2	-2238
Gnai1	-6455
Gnai3	-6813

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy6	8809
Adcy4	8797
Adcy5	7463
Adcy8	7208
Adcy2	6109
Adcy9	5538
Adcy3	5526
Adcy7	5405
Gnal	4618
Adcy1	3289
Gnai2	-2238
Gnai1	-6455
Gnai3	-6813

---

METHYLATION

set	METHYLATION
setSize	11
pANOVA	0.0299
s.dist	-0.378
p.adjustANOVA	0.117

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Gsto1	-7815
Mat2a	-7552
Mat2b	-7544
N6amt1	-7198
Tpmt	-6187
Ahcy	-4615
Comt	-4030
Mtrr	-418
Trmt112	2119
As3mt	2460
Mtr	8138

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Gsto1	-7815
Mat2a	-7552
Mat2b	-7544
N6amt1	-7198
Tpmt	-6187
Ahcy	-4615
Comt	-4030
Mtrr	-418
Trmt112	2119
As3mt	2460
Mtr	8138

---

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

set	A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize	26
pANOVA	0.000912
s.dist	0.376
p.adjustANOVA	0.00762

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Cspg4	8445
Ncan	8142
Gpc2	8056
Sdc4	7952
Agrn	7775
Bcan	7332
Xylt2	6937
Gpc4	6872
Gpc3	5372
B3gat1	5211
Sdc3	4440
Hspg2	4414
Gpc1	4373
Bgn	4061
Vcan	4055
B4galt7	3015
Xylt1	2356
Gpc6	1264
B3galt6	288
B3gat2	271

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Cspg4	8445
Ncan	8142
Gpc2	8056
Sdc4	7952
Agrn	7775
Bcan	7332
Xylt2	6937
Gpc4	6872
Gpc3	5372
B3gat1	5211
Sdc3	4440
Hspg2	4414
Gpc1	4373
Bgn	4061
Vcan	4055
B4galt7	3015
Xylt1	2356
Gpc6	1264
B3galt6	288
B3gat2	271
Dcn	238
Sdc1	-59
Gpc5	-316
Cspg5	-584
B3gat3	-1288
Sdc2	-4728

---

ORC1 REMOVAL FROM CHROMATIN

set	ORC1 REMOVAL FROM CHROMATIN
setSize	68
pANOVA	8.6e-08
s.dist	-0.375
p.adjustANOVA	3.57e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Orc5	-7807
Orc6	-7774
Skp1	-7765
Psma6	-7581
Cul1	-7451
Orc4	-7372
Psma2	-7178
Psmd6	-7173
Mcm3	-7064
Psmf1	-7033
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5507

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Orc5	-7807
Orc6	-7774
Skp1	-7765
Psma6	-7581
Cul1	-7451
Orc4	-7372
Psma2	-7178
Psmd6	-7173
Mcm3	-7064
Psmf1	-7033
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Orc2	-5807
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067
Psma4	-4819
Rbx1	-4731
Psmd5	-4607
Psmb3	-4594
Psma3	-4521
Ubb	-4225
Rps27a	-4128
Psme2	-4125
Mcm4	-4081
Psma7	-3984
Psma8	-3888
Mcm5	-3622
Psmd9	-3336
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Mcm8	-2254
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Psmb4	-1485
Orc3	-1298
Mcm6	-1096
Cdt1	-1095
Skp2	-450
Psmd11	-127
Mcm2	-30
Psmc4	123
Mcm7	443
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Ccna1	3448
Ubc	3482
Psme4	3592
Uba52	3693
Ccna2	5459
Cdk2	6754

---

PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR

set	PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR
setSize	20
pANOVA	0.00371
s.dist	-0.375
p.adjustANOVA	0.0246

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rfc3	-8030
Apex1	-7964
Pole4	-7962
Pcna	-7540
Pole3	-6995
Rfc4	-6969
Rpa3	-6925
Rfc5	-4482
Pold2	-4372
Rpa2	-4355
Polb	-4257
Fen1	-3971
Rpa1	-3834
Pold4	-3366
Pole	152
Pold3	2037
Rfc2	3276
Rfc1	3958
Pold1	4156
Lig1	8707

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rfc3	-8030
Apex1	-7964
Pole4	-7962
Pcna	-7540
Pole3	-6995
Rfc4	-6969
Rpa3	-6925
Rfc5	-4482
Pold2	-4372
Rpa2	-4355
Polb	-4257
Fen1	-3971
Rpa1	-3834
Pold4	-3366
Pole	152
Pold3	2037
Rfc2	3276
Rfc1	3958
Pold1	4156
Lig1	8707

---

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

set	SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
setSize	12
pANOVA	0.0249
s.dist	-0.374
p.adjustANOVA	0.104

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Pla2g7	-8175
Spcs3	-7822
Bche	-6522
Spcs2	-6276
Spcs1	-5475
Sec11c	-4613
Klf4	-4240
Pcsk1	-731
Sec11a	-585
Igf1	-186
Crhr2	1637
Ache	7825

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Pla2g7	-8175
Spcs3	-7822
Bche	-6522
Spcs2	-6276
Spcs1	-5475
Sec11c	-4613
Klf4	-4240
Pcsk1	-731
Sec11a	-585
Igf1	-186
Crhr2	1637
Ache	7825

---

SCF SKP2 MEDIATED DEGRADATION OF P27 P21

set	SCF SKP2 MEDIATED DEGRADATION OF P27 P21
setSize	59
pANOVA	7.76e-07
s.dist	-0.372
p.adjustANOVA	2.18e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ccne2	-8218
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Skp1	-7765
Psma6	-7581
Cul1	-7451
Cdkn1b	-7419
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ccne2	-8218
Psmc6	-8205
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Skp1	-7765
Psma6	-7581
Cul1	-7451
Cdkn1b	-7419
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Psma1	-6555
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Psmc2	-5067
Ccnd1	-4879
Psma4	-4819
Psmd5	-4607
Psmb3	-4594
Psma3	-4521
Ubb	-4225
Rps27a	-4128
Psme2	-4125
Psma7	-3984
Ccne1	-3687
Psmd9	-3336
Cks1b	-3110
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Psmb4	-1485
Skp2	-450
Psmd11	-127
Psmc4	123
Cdk4	372
Psme1	709
Psmb5	728
Psmd1	1046
Cdkn1a	1168
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Ccna1	3448
Ubc	3482
Uba52	3693
Ccna2	5459
Cdk2	6754

---

PROTEIN UBIQUITINATION

set	PROTEIN UBIQUITINATION
setSize	70
pANOVA	7.61e-08
s.dist	-0.372
p.adjustANOVA	3.32e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8222
Ube2v2	-8215
Ube2q2	-8179
Ube2d3	-8174
Uchl3	-8039
Ube2e1	-7974
Ube2b	-7943
Ube2a	-7922
Ube2l3	-7832
Ube2n	-7816
Ube2k	-7806
Ube2d2a	-7702
Pcna	-7540
Pex13	-7517
Pex2	-7321
Selenos	-7113
Ube2j2	-6882

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2w	-8355
Ube2e3	-8352
Ube2g1	-8298
Ube2d1	-8222
Ube2v2	-8215
Ube2q2	-8179
Ube2d3	-8174
Uchl3	-8039
Ube2e1	-7974
Ube2b	-7943
Ube2a	-7922
Ube2l3	-7832
Ube2n	-7816
Ube2k	-7806
Ube2d2a	-7702
Pcna	-7540
Pex13	-7517
Pex2	-7321
Selenos	-7113
Ube2j2	-6882
Rnf181	-6842
Wdr61	-6291
Bcl10	-6256
Rnf152	-6149
Derl1	-5942
H2-D1	-5834
Ube2r2	-5536
Cdc73	-5407
H2bc6	-5193
H2bc21	-5033
Wac	-4872
H2bc4	-4790
Ube2s	-4655
H2-Q7	-4561
Otulin	-4527
Cdc34	-4476
Ubb	-4225
Rps27a	-4128
Rraga	-3748
Ube2t	-3532
Uba6	-3400
H2-Q2	-3155
Rad18	-3035
Leo1	-2493
Usp9x	-2429
Pex14	-2366
Rnf144a	-1706
Ube2z	-1186
Ctr9	-1053
Pex12	172
H2-Q10	706
Hltf	1251
Vcp	1696
Pex10	2168
Usp5	2236
Shprh	2248
Ube2h	2264
Ube2g2	2749
Usp7	2986
Ubc	3482
H2bc12	3669
Uba52	3693
Rnf40	4191
Uba1	4505
Paf1	4793
Pex5	5914
Tmem129	5963
Rtf1	6098
Prkdc	7228
Rnf20	9018

---

PROCESSING AND ACTIVATION OF SUMO

set	PROCESSING AND ACTIVATION OF SUMO
setSize	10
pANOVA	0.0421
s.dist	-0.371
p.adjustANOVA	0.147

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Sumo2	-7744
Sumo1	-7653
Rwdd3	-6572
Sumo3	-5432
Uba2	-4596
Senp2	-2624
Ube2i	-2353
Sae1	-35
Senp5	2143
Senp1	5796

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Sumo2	-7744
Sumo1	-7653
Rwdd3	-6572
Sumo3	-5432
Uba2	-4596
Senp2	-2624
Ube2i	-2353
Sae1	-35
Senp5	2143
Senp1	5796

---

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

set	FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize	18
pANOVA	0.00695
s.dist	-0.367
p.adjustANOVA	0.0402

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atp5c1	-8077
Atp5pb	-7500
Dmac2l	-7279
mt-Atp6	-5074
Atp5b	-4889
Atp5h	-4816
Atp5o	-4702
Atp5l	-4688
Atp5a1	-4506
Atp5g3	-4462
Atp5g2	-3063
Atp5j2	-1522
Atp5e	-1120
Atp5j	-1104
Atp5d	320
Atp5g1	1350
Atp5k	2052
mt-Atp8	7356

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atp5c1	-8077
Atp5pb	-7500
Dmac2l	-7279
mt-Atp6	-5074
Atp5b	-4889
Atp5h	-4816
Atp5o	-4702
Atp5l	-4688
Atp5a1	-4506
Atp5g3	-4462
Atp5g2	-3063
Atp5j2	-1522
Atp5e	-1120
Atp5j	-1104
Atp5d	320
Atp5g1	1350
Atp5k	2052
mt-Atp8	7356

---

COMPLEX I BIOGENESIS

set	COMPLEX I BIOGENESIS
setSize	56
pANOVA	2.04e-06
s.dist	-0.367
p.adjustANOVA	4.63e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ndufaf1	-7781
Ndufaf4	-7558
Ndufv2	-7288
Nubpl	-7181
mt-Nd2	-7058
Ndufc2	-6894
mt-Nd6	-6545
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
mt-Nd1	-5998
Ndufaf2	-5957
mt-Nd5	-5921
Ndufb5	-5763
Ndufs1	-5654
Ndufb11	-4982
Ndufs8	-4554
Ndufs3	-4362
Ndufa10	-4303
Ndufab1	-4273

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ndufaf1	-7781
Ndufaf4	-7558
Ndufv2	-7288
Nubpl	-7181
mt-Nd2	-7058
Ndufc2	-6894
mt-Nd6	-6545
mt-Nd4	-6197
Ndufs4	-6192
Ndufaf5	-6126
mt-Nd1	-5998
Ndufaf2	-5957
mt-Nd5	-5921
Ndufb5	-5763
Ndufs1	-5654
Ndufb11	-4982
Ndufs8	-4554
Ndufs3	-4362
Ndufa10	-4303
Ndufab1	-4273
Ndufb4	-4258
Ndufb9	-4244
Ndufb3	-4242
Ndufb8	-3926
Ndufb6	-3356
Tmem126b	-3346
Ndufa11	-3133
Ndufb10	-2957
Ecsit	-2886
Ndufa9	-2859
Ndufs5	-2850
Ndufa7	-2651
Ndufs2	-2592
Ndufb2	-2482
Ndufc1	-2359
Ndufa8	-1986
Ndufv1	-1560
Ndufa2	-1533
Ndufa5	-1345
Ndufaf3	-1246
Ndufb1	-1103
Timmdc1	-816
Acad9	-691
Ndufb7	-650
Ndufa6	-561
Ndufa1	-470
mt-Nd3	257
Ndufaf6	359
Ndufs6	991
Ndufv3	1180
Ndufa13	1624
Ndufa3	1809
Ndufaf7	1852
Ndufs7	1887
Ndufa12	3484
Tmem186	6998

---

APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1

set	APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
setSize	71
pANOVA	9.15e-08
s.dist	-0.367
p.adjustANOVA	3.6e-06

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ube2d1	-8222
Psmc6	-8205
Ube2e1	-7974
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Psma6	-7581
Anapc10	-7448
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Cdc26	-6730
Psma1	-6555
Cdc16	-6482
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ube2d1	-8222
Psmc6	-8205
Ube2e1	-7974
Psmd14	-7966
Psmd12	-7879
Psmb9	-7863
Psma6	-7581
Anapc10	-7448
Psma2	-7178
Psmd6	-7173
Psmf1	-7033
Cdc26	-6730
Psma1	-6555
Cdc16	-6482
Psmd8	-6194
Psmb8	-6188
Psma5	-5800
Psmb1	-5507
Psmd10	-5498
Psmb7	-5402
Pttg1	-5341
Psmc2	-5067
Cdc27	-5034
Aurka	-4990
Psma4	-4819
Ube2s	-4655
Psmd5	-4607
Psmb3	-4594
Anapc7	-4523
Psma3	-4521
Ubb	-4225
Rps27a	-4128
Psme2	-4125
Anapc16	-4039
Psma7	-3984
Psma8	-3888
Rb1	-3759
Cdc23	-3460
Psmd9	-3336
Anapc4	-3101
Anapc15	-2461
Psmd13	-2451
Sem1	-2434
Psme3	-2375
Psmc3	-2349
Anapc11	-2259
Psmb10	-2158
Psmc1	-1694
Psmb6	-1663
Psmb2	-1640
Psmc5	-1557
Psmb4	-1485
Fzr1	-1003
Skp2	-450
Plk1	-337
Psmd11	-127
Psmc4	123
Psme1	709
Psmb5	728
Psmd1	1046
Psmd7	1454
Psmd4	2249
Psmd3	2920
Psmd2	3352
Ubc	3482
Psme4	3592
Uba52	3693
Anapc1	5841
Anapc5	5967
Cdc20	6097
Anapc2	7416

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report