date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik -1.1332185
0610009E02Rik -0.3290659
0610009L18Rik 0.1306738
0610010K14Rik -0.3126674
0610012G03Rik -0.2034285
0610030E20Rik -0.5747514

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17372
duplicated_genes_present 0
num_profile_genes_in_sets 8443
num_profile_genes_not_in_sets 8929

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 425
num_genesets_included 1179

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.27e-05 0.612 5.53e-04
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 1.98e-03 -0.565 2.18e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 3.95e-03 0.502 3.75e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.69e-03 -0.492 4.29e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 7.91e-03 0.485 6.21e-02
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 2.37e-04 0.475 4.98e-03
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 9.54e-03 0.473 7.06e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 6.85e-05 0.451 2.07e-03
RUNX3 REGULATES NOTCH SIGNALING 13 4.87e-03 0.451 4.38e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.59e-04 0.446 8.98e-03
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.99e-05 0.443 1.63e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.70e-02 0.436 1.02e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.45e-04 0.431 6.44e-03
MITOCHONDRIAL TRANSLATION 93 7.17e-13 -0.430 4.23e-10
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 6.18e-05 -0.430 1.92e-03
P75NTR REGULATES AXONOGENESIS 10 1.96e-02 -0.426 1.13e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 1.33e-03 0.425 1.63e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 1.41e-02 0.409 9.13e-02
CRISTAE FORMATION 31 8.17e-05 -0.409 2.31e-03
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 6.25e-03 0.408 5.30e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.52e-03 -0.400 2.68e-02
SIGNALING BY LEPTIN 10 2.84e-02 0.400 1.43e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.39e-05 0.396 9.39e-04
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.17e-04 0.393 3.15e-03
INTERLEUKIN 6 SIGNALING 10 3.18e-02 0.392 1.51e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 4.07e-03 -0.391 3.84e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.47e-02 -0.386 1.56e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 20 3.09e-03 -0.382 3.12e-02
RESPIRATORY ELECTRON TRANSPORT 102 2.92e-11 -0.381 8.61e-09
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 2.90e-02 -0.380 1.44e-01
ASPARTATE AND ASPARAGINE METABOLISM 11 2.91e-02 -0.380 1.44e-01
PHASE 2 PLATEAU PHASE 12 2.27e-02 0.380 1.22e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 9.78e-04 -0.374 1.33e-02
COMPLEX I BIOGENESIS 56 1.97e-06 -0.367 1.16e-04
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 1.74e-02 0.367 1.03e-01
ACTIVATION OF SMO 16 1.12e-02 0.366 7.85e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 2.27e-02 0.365 1.22e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 1.03e-03 0.365 1.37e-02
CITRIC ACID CYCLE TCA CYCLE 22 3.16e-03 -0.364 3.16e-02
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 15 1.50e-02 0.363 9.50e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.78e-12 -0.362 1.09e-09
MITOCHONDRIAL PROTEIN IMPORT 63 7.91e-07 -0.360 6.22e-05
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 3.21e-02 0.357 1.51e-01
CHOLESTEROL BIOSYNTHESIS 24 2.49e-03 -0.357 2.67e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.29e-02 0.356 1.53e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 1.72e-02 0.355 1.03e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 1.51e-03 0.353 1.80e-02
PENTOSE PHOSPHATE PATHWAY 13 2.85e-02 -0.351 1.43e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.51e-02 0.351 9.50e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 2.91e-02 0.349 1.44e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.27e-05 0.612000 5.53e-04
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 1.98e-03 -0.565000 2.18e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 3.95e-03 0.502000 3.75e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.69e-03 -0.492000 4.29e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 7.91e-03 0.485000 6.21e-02
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 2.37e-04 0.475000 4.98e-03
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 9.54e-03 0.473000 7.06e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 6.85e-05 0.451000 2.07e-03
RUNX3 REGULATES NOTCH SIGNALING 13 4.87e-03 0.451000 4.38e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.59e-04 0.446000 8.98e-03
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.99e-05 0.443000 1.63e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.70e-02 0.436000 1.02e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.45e-04 0.431000 6.44e-03
MITOCHONDRIAL TRANSLATION 93 7.17e-13 -0.430000 4.23e-10
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 6.18e-05 -0.430000 1.92e-03
P75NTR REGULATES AXONOGENESIS 10 1.96e-02 -0.426000 1.13e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 1.33e-03 0.425000 1.63e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 1.41e-02 0.409000 9.13e-02
CRISTAE FORMATION 31 8.17e-05 -0.409000 2.31e-03
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 6.25e-03 0.408000 5.30e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.52e-03 -0.400000 2.68e-02
SIGNALING BY LEPTIN 10 2.84e-02 0.400000 1.43e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.39e-05 0.396000 9.39e-04
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.17e-04 0.393000 3.15e-03
INTERLEUKIN 6 SIGNALING 10 3.18e-02 0.392000 1.51e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 4.07e-03 -0.391000 3.84e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.47e-02 -0.386000 1.56e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 20 3.09e-03 -0.382000 3.12e-02
RESPIRATORY ELECTRON TRANSPORT 102 2.92e-11 -0.381000 8.61e-09
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 2.90e-02 -0.380000 1.44e-01
ASPARTATE AND ASPARAGINE METABOLISM 11 2.91e-02 -0.380000 1.44e-01
PHASE 2 PLATEAU PHASE 12 2.27e-02 0.380000 1.22e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 9.78e-04 -0.374000 1.33e-02
COMPLEX I BIOGENESIS 56 1.97e-06 -0.367000 1.16e-04
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 1.74e-02 0.367000 1.03e-01
ACTIVATION OF SMO 16 1.12e-02 0.366000 7.85e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 2.27e-02 0.365000 1.22e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 1.03e-03 0.365000 1.37e-02
CITRIC ACID CYCLE TCA CYCLE 22 3.16e-03 -0.364000 3.16e-02
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 15 1.50e-02 0.363000 9.50e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.78e-12 -0.362000 1.09e-09
MITOCHONDRIAL PROTEIN IMPORT 63 7.91e-07 -0.360000 6.22e-05
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 3.21e-02 0.357000 1.51e-01
CHOLESTEROL BIOSYNTHESIS 24 2.49e-03 -0.357000 2.67e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.29e-02 0.356000 1.53e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 1.72e-02 0.355000 1.03e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 1.51e-03 0.353000 1.80e-02
PENTOSE PHOSPHATE PATHWAY 13 2.85e-02 -0.351000 1.43e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.51e-02 0.351000 9.50e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 2.91e-02 0.349000 1.44e-01
LGI ADAM INTERACTIONS 14 2.37e-02 0.349000 1.25e-01
FGFR2 LIGAND BINDING AND ACTIVATION 13 3.06e-02 -0.346000 1.49e-01
EARLY PHASE OF HIV LIFE CYCLE 13 3.15e-02 -0.345000 1.50e-01
CS DS DEGRADATION 14 2.72e-02 0.341000 1.38e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 5.47e-02 0.334000 2.08e-01
RORA ACTIVATES GENE EXPRESSION 18 1.41e-02 0.334000 9.13e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 4.05e-14 -0.334000 4.77e-11
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 9.82e-03 -0.334000 7.10e-02
SCAVENGING OF HEME FROM PLASMA 10 6.91e-02 -0.332000 2.43e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.41e-03 -0.331000 1.69e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 7.03e-02 -0.331000 2.44e-01
PROCESSING OF SMDT1 16 2.23e-02 -0.330000 1.22e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 40 3.42e-04 0.327000 6.44e-03
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 7.39e-02 0.326000 2.51e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 7.39e-02 0.326000 2.51e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 1.12e-02 0.320000 7.85e-02
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 2.41e-02 0.316000 1.26e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 3.43e-02 0.316000 1.56e-01
ORC1 REMOVAL FROM CHROMATIN 69 5.96e-06 -0.315000 3.19e-04
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 7.05e-02 0.315000 2.44e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 14 4.16e-02 0.315000 1.74e-01
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION 10 8.67e-02 -0.313000 2.70e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.77e-02 -0.312000 2.70e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 7.44e-02 0.311000 2.52e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 88 4.75e-07 -0.311000 4.31e-05
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 5.26e-02 -0.310000 2.06e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 6.37e-02 -0.309000 2.31e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.68e-02 -0.309000 1.02e-01
METALLOPROTEASE DUBS 25 7.72e-03 -0.308000 6.15e-02
BIOTIN TRANSPORT AND METABOLISM 11 7.83e-02 0.307000 2.57e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 84 1.65e-06 -0.303000 1.03e-04
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 9.28e-03 0.301000 6.94e-02
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 3.34e-03 0.300000 3.25e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 8.22e-05 -0.296000 2.31e-03
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.54e-02 -0.296000 1.30e-01
INTERLEUKIN 7 SIGNALING 19 2.56e-02 0.296000 1.30e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 66 3.70e-05 -0.294000 1.36e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.95e-04 -0.293000 4.33e-03
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 1.09e-01 0.293000 3.12e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 6.18e-03 0.289000 5.28e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 72 2.57e-05 -0.287000 9.78e-04
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 1.16e-01 0.287000 3.24e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 27 1.03e-02 -0.285000 7.38e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 69 4.32e-05 -0.285000 1.54e-03
SIGNALING BY NOTCH3 48 6.63e-04 0.284000 9.78e-03
DNA REPLICATION PRE INITIATION 81 1.01e-05 -0.284000 4.59e-04
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 21 2.48e-02 -0.283000 1.29e-01
HIV TRANSCRIPTION INITIATION 45 1.05e-03 -0.282000 1.37e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 8.81e-03 0.281000 6.66e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 48 8.04e-04 -0.280000 1.13e-02
METABOLISM OF POLYAMINES 59 2.04e-04 -0.280000 4.45e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 9.36e-02 -0.280000 2.84e-01
ELASTIC FIBRE FORMATION 38 3.00e-03 0.278000 3.05e-02
G PROTEIN ACTIVATION 23 2.11e-02 0.278000 1.19e-01
INTERLEUKIN 12 SIGNALING 36 3.93e-03 -0.278000 3.75e-02
PHOSPHORYLATION OF THE APC C 18 4.14e-02 -0.278000 1.74e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 3.73e-02 -0.276000 1.63e-01
RECEPTOR MEDIATED MITOPHAGY 11 1.13e-01 -0.276000 3.21e-01
MET ACTIVATES RAP1 AND RAC1 10 1.33e-01 -0.275000 3.50e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 2.39e-03 -0.274000 2.59e-02
DEGRADATION OF DVL 57 3.55e-04 -0.274000 6.44e-03
TIGHT JUNCTION INTERACTIONS 17 5.10e-02 -0.273000 2.02e-01
CRMPS IN SEMA3A SIGNALING 16 5.95e-02 0.272000 2.20e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 65 1.55e-04 -0.271000 3.72e-03
SIGNALING BY NTRK3 TRKC 17 5.38e-02 0.270000 2.07e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 1.21e-01 0.270000 3.36e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 55 5.71e-04 -0.269000 8.98e-03
REGULATION OF TLR BY ENDOGENOUS LIGAND 14 8.22e-02 -0.268000 2.62e-01
DNA REPLICATION 123 2.78e-07 -0.268000 2.98e-05
G1 S DNA DAMAGE CHECKPOINTS 67 1.50e-04 -0.268000 3.69e-03
REGULATION OF IFNA SIGNALING 12 1.09e-01 0.267000 3.13e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 1.31e-02 -0.266000 8.67e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.90e-02 -0.266000 1.11e-01
SIGNALING BY NOTCH2 33 8.33e-03 0.265000 6.46e-02
PROTEIN UBIQUITINATION 70 1.24e-04 -0.265000 3.24e-03
REPRESSION OF WNT TARGET GENES 14 8.65e-02 0.265000 2.70e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 61 3.53e-04 -0.265000 6.44e-03
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 4.75e-02 -0.263000 1.93e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 80 4.93e-05 -0.263000 1.63e-03
STABILIZATION OF P53 56 7.09e-04 -0.262000 1.01e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 1.05e-02 0.262000 7.47e-02
N GLYCAN ANTENNAE ELONGATION 15 7.97e-02 0.261000 2.58e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 6.22e-02 0.261000 2.28e-01
REGULATION OF TNFR1 SIGNALING 34 8.45e-03 0.261000 6.47e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 1.29e-03 -0.261000 1.60e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.86e-03 0.260000 2.13e-02
FCERI MEDIATED NF KB ACTIVATION 78 7.51e-05 -0.259000 2.21e-03
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 71 1.63e-04 -0.259000 3.76e-03
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 5.75e-02 0.259000 2.15e-01
S PHASE 155 2.87e-08 -0.258000 3.75e-06
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 3.63e-02 -0.258000 1.61e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.23e-01 0.257000 3.38e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 4.82e-05 -0.257000 1.63e-03
CELLULAR RESPONSE TO HYPOXIA 74 1.47e-04 -0.255000 3.68e-03
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 1.01e-01 0.253000 2.97e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 1.46e-01 0.253000 3.72e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 5.71e-02 -0.252000 2.14e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 1.67e-01 -0.252000 3.98e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 3.64e-02 -0.252000 1.61e-01
HYALURONAN METABOLISM 15 9.15e-02 0.252000 2.79e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 3.29e-02 -0.252000 1.53e-01
CYTOSOLIC TRNA AMINOACYLATION 24 3.36e-02 -0.251000 1.54e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 5.45e-02 0.248000 2.08e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 2.54e-03 0.247000 2.68e-02
COHESIN LOADING ONTO CHROMATIN 10 1.77e-01 -0.247000 4.14e-01
CD28 DEPENDENT VAV1 PATHWAY 11 1.59e-01 -0.245000 3.88e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 22 4.67e-02 -0.245000 1.91e-01
RAB GERANYLGERANYLATION 58 1.26e-03 -0.245000 1.59e-02
G2 M DNA DAMAGE CHECKPOINT 66 6.15e-04 -0.244000 9.42e-03
DEGRADATION OF GLI1 BY THE PROTEASOME 59 1.23e-03 -0.243000 1.56e-02
FGFR1 LIGAND BINDING AND ACTIVATION 10 1.84e-01 -0.242000 4.23e-01
G2 M CHECKPOINTS 135 1.18e-06 -0.242000 8.21e-05
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 2.18e-02 0.242000 1.21e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 2.23e-02 -0.241000 1.22e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 1.33e-01 -0.241000 3.50e-01
NEPHRIN FAMILY INTERACTIONS 23 4.56e-02 0.241000 1.88e-01
PEXOPHAGY 11 1.67e-01 0.240000 3.98e-01
REGULATION OF BACH1 ACTIVITY 11 1.68e-01 -0.240000 3.98e-01
PI 3K CASCADE FGFR2 17 8.72e-02 -0.240000 2.70e-01
PYRUVATE METABOLISM 27 3.29e-02 -0.237000 1.53e-01
PROTEIN LOCALIZATION 157 3.24e-07 -0.236000 3.18e-05
DCC MEDIATED ATTRACTIVE SIGNALING 14 1.26e-01 0.236000 3.43e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.56e-01 -0.236000 3.86e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 9.58e-03 0.234000 7.06e-02
DEGRADATION OF AXIN 55 2.71e-03 -0.234000 2.82e-02
FRS MEDIATED FGFR2 SIGNALING 19 7.79e-02 -0.234000 2.56e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 2.96e-02 -0.233000 1.46e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 1.81e-01 0.233000 4.18e-01
RND2 GTPASE CYCLE 39 1.18e-02 0.233000 8.09e-02
EPHRIN SIGNALING 19 8.07e-02 0.231000 2.60e-01
HDMS DEMETHYLATE HISTONES 26 4.12e-02 0.231000 1.73e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 4.31e-03 -0.231000 4.00e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 1.50e-01 -0.230000 3.77e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 1.11e-01 -0.230000 3.18e-01
FORMATION OF APOPTOSOME 10 2.09e-01 -0.230000 4.58e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.37e-01 0.229000 3.57e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 8.36e-02 -0.229000 2.65e-01
RND3 GTPASE CYCLE 38 1.45e-02 0.229000 9.27e-02
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 2.27e-02 -0.229000 1.22e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 4.75e-02 -0.229000 1.93e-01
PROCESSING AND ACTIVATION OF SUMO 10 2.10e-01 -0.229000 4.60e-01
GLUTATHIONE CONJUGATION 29 3.32e-02 -0.228000 1.53e-01
SIGNALING BY NOTCH1 75 6.64e-04 0.227000 9.78e-03
MITOTIC G1 PHASE AND G1 S TRANSITION 141 3.43e-06 -0.227000 1.93e-04
CA2 PATHWAY 58 2.85e-03 0.227000 2.92e-02
TRANSLESION SYNTHESIS BY POLK 17 1.06e-01 -0.226000 3.08e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 1.29e-01 -0.226000 3.48e-01
PROTEIN METHYLATION 17 1.06e-01 -0.226000 3.08e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.74e-02 0.226000 1.03e-01
RHOB GTPASE CYCLE 69 1.22e-03 0.225000 1.56e-02
RHOC GTPASE CYCLE 74 8.50e-04 0.224000 1.16e-02
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 3.11e-02 -0.224000 1.50e-01
CLEC7A DECTIN 1 SIGNALING 96 1.60e-04 -0.223000 3.76e-03
SEPARATION OF SISTER CHROMATIDS 169 6.19e-07 -0.222000 5.22e-05
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.24e-03 -0.222000 4.61e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 7.92e-02 -0.221000 2.58e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 3.65e-02 0.221000 1.61e-01
INSULIN RECEPTOR RECYCLING 20 8.80e-02 -0.220000 2.70e-01
CELL CYCLE CHECKPOINTS 245 2.94e-09 -0.220000 6.92e-07
REGULATION OF INSULIN SECRETION 72 1.23e-03 0.220000 1.56e-02
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 70 1.60e-03 -0.218000 1.88e-02
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.92e-01 0.218000 4.34e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.92e-01 -0.217000 4.35e-01
PERK REGULATES GENE EXPRESSION 28 4.78e-02 -0.216000 1.94e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.96e-01 -0.216000 4.40e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 4.26e-03 0.215000 3.98e-02
SIGNALING BY FGFR2 IN DISEASE 37 2.38e-02 -0.215000 1.25e-01
CELLULAR HEXOSE TRANSPORT 11 2.18e-01 0.214000 4.73e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 7.58e-02 0.214000 2.54e-01
TNF SIGNALING 43 1.52e-02 0.214000 9.51e-02
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 7.63e-02 0.214000 2.54e-01
MUCOPOLYSACCHARIDOSES 11 2.20e-01 0.213000 4.74e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 2.21e-01 -0.213000 4.74e-01
GP1B IX V ACTIVATION SIGNALLING 11 2.21e-01 0.213000 4.74e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 1.56e-02 0.213000 9.69e-02
NRAGE SIGNALS DEATH THROUGH JNK 56 5.83e-03 0.213000 5.05e-02
RMTS METHYLATE HISTONE ARGININES 42 1.70e-02 0.213000 1.02e-01
G ALPHA 12 13 SIGNALLING EVENTS 76 1.36e-03 0.213000 1.65e-02
INTERLEUKIN 12 FAMILY SIGNALING 43 1.59e-02 -0.212000 9.78e-02
PYRIMIDINE CATABOLISM 10 2.47e-01 -0.212000 5.03e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 14 1.72e-01 -0.211000 4.04e-01
INTEGRATION OF ENERGY METABOLISM 100 2.75e-04 0.211000 5.49e-03
RHO GTPASES ACTIVATE NADPH OXIDASES 22 8.77e-02 -0.210000 2.70e-01
DERMATAN SULFATE BIOSYNTHESIS 11 2.28e-01 0.210000 4.80e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.14e-01 0.210000 3.21e-01
MRNA CAPPING 29 5.17e-02 -0.209000 2.04e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 1.63e-01 0.208000 3.93e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 2.55e-01 0.208000 5.14e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.28e-02 -0.208000 8.57e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.51e-01 -0.207000 3.78e-01
CDC42 GTPASE CYCLE 155 9.10e-06 0.207000 4.36e-04
DARPP 32 EVENTS 23 8.63e-02 -0.207000 2.70e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 49 1.28e-02 0.206000 8.57e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 1.22e-01 0.205000 3.38e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 3.14e-02 -0.204000 1.50e-01
G0 AND EARLY G1 25 7.71e-02 -0.204000 2.55e-01
NEUROTRANSMITTER RELEASE CYCLE 49 1.39e-02 0.203000 9.11e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.36e-01 -0.203000 3.55e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 1.58e-02 0.201000 9.75e-02
G1 S SPECIFIC TRANSCRIPTION 27 7.01e-02 -0.201000 2.44e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 61 6.58e-03 -0.201000 5.42e-02
INTERLEUKIN 15 SIGNALING 13 2.10e-01 0.201000 4.60e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 6.23e-02 0.200000 2.28e-01
NEUREXINS AND NEUROLIGINS 54 1.11e-02 0.200000 7.85e-02
RET SIGNALING 36 3.85e-02 0.199000 1.65e-01
INTEGRIN SIGNALING 24 9.14e-02 0.199000 2.79e-01
OTHER SEMAPHORIN INTERACTIONS 19 1.33e-01 0.199000 3.50e-01
G ALPHA S SIGNALLING EVENTS 109 3.51e-04 0.198000 6.44e-03
C TYPE LECTIN RECEPTORS CLRS 115 2.47e-04 -0.198000 5.02e-03
FORMATION OF INCISION COMPLEX IN GG NER 43 2.49e-02 -0.198000 1.29e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 2.01e-01 0.198000 4.47e-01
PRE NOTCH PROCESSING IN GOLGI 17 1.59e-01 0.197000 3.88e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 2.38e-01 0.197000 4.94e-01
RA BIOSYNTHESIS PATHWAY 14 2.03e-01 -0.197000 4.51e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 63 7.02e-03 -0.196000 5.75e-02
RESOLUTION OF D LOOP STRUCTURES 31 5.85e-02 -0.196000 2.18e-01
MITOTIC TELOPHASE CYTOKINESIS 13 2.21e-01 -0.196000 4.74e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 1.30e-01 -0.196000 3.48e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 69 4.95e-03 -0.196000 4.40e-02
PLASMA LIPOPROTEIN REMODELING 13 2.22e-01 0.196000 4.74e-01
TRAFFICKING OF AMPA RECEPTORS 31 5.98e-02 0.195000 2.20e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 28 7.36e-02 -0.195000 2.51e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 52 1.51e-02 0.195000 9.50e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 8.03e-02 0.195000 2.59e-01
PRE NOTCH EXPRESSION AND PROCESSING 62 8.16e-03 0.194000 6.37e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 2.25e-01 0.194000 4.78e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 1.55e-01 0.194000 3.84e-01
HS GAG DEGRADATION 22 1.16e-01 0.193000 3.24e-01
MITOTIC METAPHASE AND ANAPHASE 210 1.40e-06 -0.193000 9.17e-05
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 86 1.98e-03 -0.193000 2.18e-02
RHOV GTPASE CYCLE 33 5.50e-02 0.193000 2.08e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.45e-01 -0.193000 3.72e-01
TRANSLATION 287 2.16e-08 -0.192000 3.64e-06
RHOBTB3 ATPASE CYCLE 10 2.94e-01 -0.192000 5.60e-01
INTERLEUKIN 37 SIGNALING 18 1.59e-01 0.192000 3.88e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 7.92e-02 -0.192000 2.58e-01
RHOU GTPASE CYCLE 34 5.32e-02 0.192000 2.07e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 1.05e-01 0.191000 3.06e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 1.86e-01 -0.191000 4.25e-01
REGULATION OF RAS BY GAPS 68 6.48e-03 -0.191000 5.39e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 5.40e-02 -0.191000 2.07e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 1.62e-01 -0.191000 3.92e-01
SIGNALING BY FGFR2 IIIA TM 19 1.51e-01 -0.190000 3.77e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 1.06e-01 0.190000 3.08e-01
TCR SIGNALING 104 8.30e-04 -0.190000 1.15e-02
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 25 1.01e-01 0.190000 2.97e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 1.71e-02 -0.189000 1.02e-01
GABA B RECEPTOR ACTIVATION 40 3.82e-02 0.189000 1.65e-01
METHYLATION 11 2.78e-01 -0.189000 5.46e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 8.41e-02 0.189000 2.66e-01
PHASE II CONJUGATION OF COMPOUNDS 63 9.72e-03 -0.188000 7.07e-02
ION TRANSPORT BY P TYPE ATPASES 49 2.32e-02 0.188000 1.23e-01
RHOA GTPASE CYCLE 144 1.05e-04 0.187000 2.87e-03
INTERLEUKIN 2 FAMILY SIGNALING 33 6.26e-02 0.187000 2.29e-01
COLLAGEN CHAIN TRIMERIZATION 41 3.90e-02 -0.186000 1.66e-01
IRON UPTAKE AND TRANSPORT 52 2.03e-02 -0.186000 1.16e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 1.31e-01 0.186000 3.49e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.86e-01 -0.186000 5.54e-01
CYTOPROTECTION BY HMOX1 120 4.58e-04 -0.185000 8.06e-03
ONCOGENE INDUCED SENESCENCE 32 6.98e-02 0.185000 2.44e-01
SULFUR AMINO ACID METABOLISM 23 1.29e-01 -0.183000 3.48e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.55e-02 -0.182000 2.09e-01
IRAK4 DEFICIENCY TLR2 4 15 2.22e-01 -0.182000 4.74e-01
MITOTIC G2 G2 M PHASES 187 1.84e-05 -0.182000 7.49e-04
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.31e-01 -0.182000 3.49e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 9.11e-02 0.181000 2.79e-01
HOST INTERACTIONS OF HIV FACTORS 128 4.03e-04 -0.181000 7.21e-03
PHASE 0 RAPID DEPOLARISATION 28 9.72e-02 0.181000 2.92e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 1.33e-01 0.181000 3.50e-01
GLYCOSPHINGOLIPID METABOLISM 38 5.41e-02 -0.181000 2.07e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 1.98e-01 -0.180000 4.43e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 5.19e-02 0.180000 2.04e-01
METABOLISM OF PORPHYRINS 19 1.75e-01 -0.180000 4.10e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 9.95e-02 -0.180000 2.96e-01
FC EPSILON RECEPTOR FCERI SIGNALING 125 5.19e-04 -0.180000 8.64e-03
RESOLUTION OF SISTER CHROMATID COHESION 103 1.66e-03 -0.179000 1.94e-02
HDR THROUGH MMEJ ALT NHEJ 10 3.26e-01 -0.179000 5.92e-01
METABOLISM OF STEROID HORMONES 21 1.56e-01 -0.179000 3.85e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 3.04e-01 -0.179000 5.70e-01
FCGR3A MEDIATED IL10 SYNTHESIS 33 7.54e-02 0.179000 2.53e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 1.15e-01 0.179000 3.23e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.08e-01 0.179000 3.12e-01
MITOTIC SPINDLE CHECKPOINT 98 2.28e-03 -0.178000 2.49e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 84 4.73e-03 -0.178000 4.29e-02
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 2.06e-01 -0.177000 4.54e-01
INTERLEUKIN 6 FAMILY SIGNALING 21 1.61e-01 0.177000 3.91e-01
REGULATION OF KIT SIGNALING 16 2.22e-01 0.176000 4.74e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.97e-03 0.176000 4.40e-02
PYROPTOSIS 21 1.62e-01 -0.176000 3.92e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 5.14e-02 0.176000 2.03e-01
ECM PROTEOGLYCANS 66 1.36e-02 0.176000 8.94e-02
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 2.96e-01 0.174000 5.60e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 1.77e-01 0.174000 4.14e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.46e-01 -0.173000 5.03e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 2.17e-01 -0.173000 4.72e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 9.31e-03 -0.173000 6.94e-02
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 2.82e-01 0.172000 5.50e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 153 2.35e-04 -0.172000 4.98e-03
HIV INFECTION 224 9.24e-06 -0.172000 4.36e-04
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.83e-01 -0.172000 4.22e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.30e-01 0.172000 3.48e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.04e-01 0.171000 5.70e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 71 1.29e-02 0.171000 8.57e-02
PECAM1 INTERACTIONS 12 3.06e-01 0.171000 5.71e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 1.57e-01 -0.170000 3.87e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 89 5.62e-03 -0.170000 4.90e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 2.71e-01 0.170000 5.40e-01
SIGNALING BY THE B CELL RECEPTOR BCR 105 2.74e-03 -0.169000 2.84e-02
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 38 7.15e-02 0.169000 2.46e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 45 5.02e-02 0.169000 2.01e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.93e-01 -0.168000 5.60e-01
RHOBTB1 GTPASE CYCLE 23 1.63e-01 -0.168000 3.93e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 2.96e-01 -0.167000 5.60e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 37 7.91e-02 -0.167000 2.58e-01
MAPK6 MAPK4 SIGNALING 86 7.69e-03 -0.166000 6.15e-02
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 54 3.46e-02 0.166000 1.56e-01
HSF1 ACTIVATION 26 1.44e-01 -0.166000 3.72e-01
HEDGEHOG LIGAND BIOGENESIS 63 2.29e-02 -0.166000 1.22e-01
HOMOLOGY DIRECTED REPAIR 106 3.28e-03 -0.165000 3.22e-02
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 122 1.78e-03 0.164000 2.06e-02
PEROXISOMAL LIPID METABOLISM 26 1.49e-01 -0.164000 3.76e-01
HDACS DEACETYLATE HISTONES 45 5.81e-02 0.163000 2.17e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 1.92e-02 0.163000 1.11e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.30e-01 0.162000 5.94e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 6.57e-02 0.162000 2.36e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 3.03e-02 0.162000 1.48e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 2.38e-01 0.161000 4.94e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.49e-01 -0.160000 3.76e-01
TRNA PROCESSING IN THE NUCLEUS 56 3.85e-02 -0.160000 1.65e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 7.45e-02 -0.159000 2.52e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 6.84e-02 -0.159000 2.42e-01
NCAM1 INTERACTIONS 40 8.23e-02 0.159000 2.62e-01
GLYCOSAMINOGLYCAN METABOLISM 116 3.19e-03 0.159000 3.16e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 3.38e-02 0.158000 1.54e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 96 7.43e-03 0.158000 6.00e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.88e-01 0.158000 6.44e-01
DAG AND IP3 SIGNALING 40 8.46e-02 0.158000 2.66e-01
G ALPHA Q SIGNALLING EVENTS 161 5.66e-04 0.158000 8.98e-03
METABOLISM OF FAT SOLUBLE VITAMINS 32 1.24e-01 0.157000 3.39e-01
SHC MEDIATED CASCADE FGFR1 16 2.78e-01 -0.157000 5.46e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 2.25e-01 0.157000 4.78e-01
SIALIC ACID METABOLISM 32 1.26e-01 -0.156000 3.43e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 3.94e-01 0.156000 6.51e-01
NONHOMOLOGOUS END JOINING NHEJ 42 8.13e-02 -0.155000 2.60e-01
AMINE LIGAND BINDING RECEPTORS 28 1.55e-01 0.155000 3.84e-01
HEME BIOSYNTHESIS 13 3.32e-01 -0.155000 5.94e-01
MITOCHONDRIAL BIOGENESIS 93 9.69e-03 -0.155000 7.07e-02
TRANSCRIPTIONAL REGULATION BY E2F6 34 1.17e-01 -0.155000 3.26e-01
RAS PROCESSING 24 1.89e-01 -0.155000 4.30e-01
REGULATION OF BETA CELL DEVELOPMENT 29 1.48e-01 0.155000 3.76e-01
INTERFERON ALPHA BETA SIGNALING 57 4.30e-02 0.155000 1.79e-01
METAL ION SLC TRANSPORTERS 25 1.80e-01 0.155000 4.18e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 3.34e-01 -0.155000 5.96e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 87 1.27e-02 0.155000 8.57e-02
PROLONGED ERK ACTIVATION EVENTS 14 3.17e-01 -0.155000 5.82e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.62e-02 0.154000 1.90e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.80e-02 0.154000 2.70e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 2.03e-01 -0.153000 4.51e-01
M PHASE 342 1.17e-06 -0.153000 8.21e-05
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 2.27e-02 0.153000 1.22e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 64 3.42e-02 -0.153000 1.56e-01
GPCR LIGAND BINDING 273 1.37e-05 0.153000 5.78e-04
SHC1 EVENTS IN ERBB4 SIGNALING 13 3.43e-01 -0.152000 6.01e-01
THE NLRP3 INFLAMMASOME 14 3.29e-01 -0.151000 5.94e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 3.47e-01 -0.151000 6.05e-01
RHOBTB2 GTPASE CYCLE 23 2.11e-01 -0.151000 4.61e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 2.22e-01 -0.151000 4.74e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 2.23e-01 -0.150000 4.75e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 4.11e-01 0.150000 6.69e-01
CHROMATIN MODIFYING ENZYMES 219 1.40e-04 0.149000 3.59e-03
RNA POLYMERASE I PROMOTER ESCAPE 46 7.95e-02 -0.149000 2.58e-01
SIGNAL AMPLIFICATION 31 1.50e-01 0.149000 3.77e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 34 1.33e-01 -0.149000 3.50e-01
MATURATION OF NUCLEOPROTEIN 10 4.15e-01 -0.149000 6.72e-01
GAB1 SIGNALOSOME 14 3.36e-01 0.149000 5.96e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 1.90e-01 0.149000 4.31e-01
GAP JUNCTION ASSEMBLY 21 2.40e-01 -0.148000 4.98e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 2.53e-01 -0.148000 5.12e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 1.69e-01 0.147000 4.00e-01
ANTIGEN PROCESSING CROSS PRESENTATION 101 1.06e-02 -0.147000 7.50e-02
MITOTIC PROMETAPHASE 178 7.07e-04 -0.147000 1.01e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.55e-02 -0.147000 1.30e-01
G PROTEIN MEDIATED EVENTS 52 6.63e-02 0.147000 2.37e-01
SIGNALING BY GPCR 490 2.73e-08 0.147000 3.75e-06
CLASS A 1 RHODOPSIN LIKE RECEPTORS 192 4.65e-04 0.147000 8.06e-03
NEDDYLATION 221 1.78e-04 -0.146000 4.04e-03
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 3.61e-01 0.146000 6.16e-01
FLT3 SIGNALING 36 1.29e-01 0.146000 3.48e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.97e-01 -0.146000 5.60e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 23 2.26e-01 0.146000 4.78e-01
ERK MAPK TARGETS 22 2.37e-01 -0.146000 4.93e-01
TRANSCRIPTION OF THE HIV GENOME 67 3.98e-02 -0.145000 1.69e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 16 3.15e-01 -0.145000 5.81e-01
SYNTHESIS OF PE 13 3.67e-01 0.144000 6.25e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 2.64e-01 0.144000 5.27e-01
GROWTH HORMONE RECEPTOR SIGNALING 21 2.54e-01 0.144000 5.14e-01
PEPTIDE LIGAND BINDING RECEPTORS 115 7.86e-03 0.144000 6.21e-02
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 2.92e-01 -0.144000 5.60e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 3.30e-02 0.143000 1.53e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 4.33e-01 0.143000 6.89e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 3.09e-02 -0.143000 1.50e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 2.27e-01 -0.143000 4.78e-01
TP53 REGULATES METABOLIC GENES 87 2.18e-02 -0.142000 1.21e-01
RHO GTPASES ACTIVATE FORMINS 120 7.12e-03 -0.142000 5.79e-02
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 1.71e-01 -0.142000 4.03e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 2.54e-02 -0.141000 1.30e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.02e-01 -0.141000 2.98e-01
INOSITOL PHOSPHATE METABOLISM 46 9.87e-02 0.141000 2.94e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 196 6.94e-04 0.141000 1.01e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 90 2.12e-02 0.141000 1.19e-01
ADHERENS JUNCTIONS INTERACTIONS 30 1.83e-01 0.140000 4.22e-01
SPHINGOLIPID METABOLISM 79 3.18e-02 -0.140000 1.51e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 29 1.94e-01 -0.139000 4.37e-01
SIGNALING BY INSULIN RECEPTOR 64 5.41e-02 -0.139000 2.07e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.95e-01 0.139000 4.39e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 48 9.60e-02 0.139000 2.89e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 3.53e-01 -0.139000 6.07e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 5.97e-02 -0.138000 2.20e-01
CELL CYCLE MITOTIC 476 2.59e-07 -0.138000 2.98e-05
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 3.11e-01 -0.138000 5.76e-01
INTERLEUKIN 10 SIGNALING 21 2.76e-01 0.137000 5.45e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 79 3.58e-02 -0.137000 1.61e-01
CHROMOSOME MAINTENANCE 101 1.78e-02 -0.137000 1.04e-01
RAF ACTIVATION 34 1.69e-01 -0.136000 4.00e-01
DISEASES OF GLYCOSYLATION 126 8.41e-03 0.136000 6.47e-02
CELL CYCLE 594 1.65e-08 -0.136000 3.25e-06
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 3.96e-01 0.136000 6.54e-01
RHO GTPASES ACTIVATE KTN1 11 4.35e-01 -0.136000 6.91e-01
MITOPHAGY 29 2.06e-01 -0.136000 4.54e-01
ANTIMICROBIAL PEPTIDES 17 3.33e-01 -0.136000 5.94e-01
FATTY ACYL COA BIOSYNTHESIS 32 1.84e-01 -0.136000 4.23e-01
INTERLEUKIN 1 SIGNALING 98 2.05e-02 -0.135000 1.17e-01
TRNA PROCESSING 105 1.70e-02 -0.135000 1.02e-01
SENSORY PROCESSING OF SOUND 61 6.88e-02 0.135000 2.43e-01
FLT3 SIGNALING IN DISEASE 28 2.18e-01 0.134000 4.73e-01
RAC1 GTPASE CYCLE 180 1.96e-03 0.134000 2.18e-02
KINESINS 48 1.10e-01 0.133000 3.14e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 53 9.30e-02 -0.133000 2.82e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 3.62e-02 -0.133000 1.61e-01
VISUAL PHOTOTRANSDUCTION 59 7.73e-02 0.133000 2.55e-01
DNA DAMAGE BYPASS 45 1.23e-01 -0.133000 3.38e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.68e-01 -0.133000 3.98e-01
PKMTS METHYLATE HISTONE LYSINES 47 1.15e-01 0.133000 3.23e-01
MHC CLASS II ANTIGEN PRESENTATION 102 2.07e-02 -0.133000 1.17e-01
ATTENUATION PHASE 24 2.61e-01 -0.132000 5.23e-01
HIV LIFE CYCLE 142 6.49e-03 -0.132000 5.39e-02
G ALPHA Z SIGNALLING EVENTS 44 1.29e-01 0.132000 3.48e-01
PEROXISOMAL PROTEIN IMPORT 58 8.13e-02 -0.132000 2.60e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 8.14e-02 -0.131000 2.60e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 4.51e-01 -0.131000 7.06e-01
ONCOGENIC MAPK SIGNALING 76 4.86e-02 0.131000 1.96e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 64 7.07e-02 -0.131000 2.44e-01
SYNTHESIS OF PA 29 2.26e-01 0.130000 4.78e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 86 3.73e-02 -0.130000 1.63e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 4.56e-01 -0.130000 7.08e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 3.28e-01 0.130000 5.94e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 3.70e-01 -0.129000 6.28e-01
EFFECTS OF PIP2 HYDROLYSIS 27 2.46e-01 0.129000 5.03e-01
TRANSLESION SYNTHESIS BY POLH 19 3.31e-01 -0.129000 5.94e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 23 2.85e-01 -0.129000 5.53e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 4.03e-02 -0.129000 1.70e-01
ACYL CHAIN REMODELLING OF PG 10 4.82e-01 -0.128000 7.34e-01
SIGNALING BY EGFR 47 1.30e-01 0.128000 3.48e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 4.64e-01 0.127000 7.17e-01
FRS MEDIATED FGFR1 SIGNALING 18 3.50e-01 -0.127000 6.07e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.81e-01 -0.127000 5.50e-01
GLUCONEOGENESIS 27 2.56e-01 -0.126000 5.15e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 3.55e-01 0.126000 6.09e-01
ABC TRANSPORTER DISORDERS 71 6.77e-02 -0.125000 2.40e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 2.88e-01 -0.125000 5.55e-01
DUAL INCISION IN TC NER 64 8.43e-02 -0.125000 2.66e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 37 1.90e-01 0.124000 4.32e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 4.39e-01 -0.124000 6.94e-01
IRS MEDIATED SIGNALLING 40 1.78e-01 -0.123000 4.14e-01
MTORC1 MEDIATED SIGNALLING 24 2.97e-01 -0.123000 5.60e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 4.43e-01 0.123000 6.99e-01
AURKA ACTIVATION BY TPX2 72 7.24e-02 -0.123000 2.48e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.82e-01 -0.122000 6.39e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 245 9.95e-04 0.122000 1.33e-02
SIGNALING BY BMP 25 2.91e-01 0.122000 5.59e-01
DNA DOUBLE STRAND BREAK REPAIR 135 1.49e-02 -0.121000 9.50e-02
NEURONAL SYSTEM 373 5.87e-05 0.121000 1.87e-03
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 31 2.43e-01 0.121000 5.00e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 9.42e-02 -0.121000 2.85e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 1.05e-01 0.121000 3.07e-01
FATTY ACID METABOLISM 147 1.16e-02 -0.121000 8.02e-02
OTHER INTERLEUKIN SIGNALING 20 3.51e-01 0.120000 6.07e-01
PI 3K CASCADE FGFR1 16 4.05e-01 -0.120000 6.63e-01
SENSORY PERCEPTION 149 1.15e-02 0.120000 7.96e-02
ERKS ARE INACTIVATED 13 4.54e-01 -0.120000 7.07e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 3.05e-02 0.120000 1.49e-01
PROGRAMMED CELL DEATH 189 4.70e-03 -0.119000 4.29e-02
NETRIN 1 SIGNALING 50 1.45e-01 0.119000 3.72e-01
SYNDECAN INTERACTIONS 26 2.93e-01 0.119000 5.60e-01
SIGNALING BY ERYTHROPOIETIN 24 3.13e-01 0.119000 5.79e-01
DEATH RECEPTOR SIGNALLING 134 1.76e-02 0.119000 1.03e-01
HYALURONAN UPTAKE AND DEGRADATION 11 4.95e-01 0.119000 7.43e-01
REGULATED NECROSIS 46 1.63e-01 -0.119000 3.93e-01
NUCLEOTIDE EXCISION REPAIR 109 3.29e-02 -0.118000 1.53e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.01e-01 -0.118000 2.97e-01
KERATAN SULFATE BIOSYNTHESIS 25 3.09e-01 0.118000 5.74e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 291 5.85e-04 -0.117000 9.07e-03
GRB2 EVENTS IN ERBB2 SIGNALING 15 4.32e-01 -0.117000 6.89e-01
GLYCOGEN SYNTHESIS 14 4.48e-01 -0.117000 7.05e-01
MRNA SPLICING MINOR PATHWAY 52 1.45e-01 -0.117000 3.72e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 2.76e-01 0.117000 5.45e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 3.70e-02 0.117000 1.63e-01
L1CAM INTERACTIONS 107 3.75e-02 0.116000 1.63e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 2.49e-01 -0.116000 5.06e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 34 2.43e-01 -0.116000 5.00e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 19 3.84e-01 -0.115000 6.41e-01
KERATAN SULFATE KERATIN METABOLISM 31 2.69e-01 0.115000 5.35e-01
PREGNENOLONE BIOSYNTHESIS 12 4.91e-01 -0.115000 7.41e-01
PYRIMIDINE SALVAGE 10 5.31e-01 0.114000 7.72e-01
SIGNALING BY NODAL 15 4.45e-01 0.114000 7.02e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 2.82e-01 -0.114000 5.50e-01
RAP1 SIGNALLING 15 4.49e-01 -0.113000 7.06e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 4.52e-01 -0.112000 7.06e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 1.46e-01 0.112000 3.73e-01
TNFR2 NON CANONICAL NF KB PATHWAY 84 7.59e-02 -0.112000 2.54e-01
UCH PROTEINASES 91 6.61e-02 -0.112000 2.37e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 4.87e-01 -0.111000 7.38e-01
MET ACTIVATES PTK2 SIGNALING 28 3.08e-01 0.111000 5.73e-01
G ALPHA I SIGNALLING EVENTS 206 5.99e-03 0.111000 5.16e-02
SEMA4D IN SEMAPHORIN SIGNALING 24 3.47e-01 0.111000 6.05e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 1.55e-01 -0.111000 3.84e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 1.59e-01 -0.110000 3.88e-01
APOPTOSIS 167 1.44e-02 -0.110000 9.27e-02
SIGNALING BY NTRK2 TRKB 24 3.53e-01 0.109000 6.07e-01
SEMAPHORIN INTERACTIONS 64 1.31e-01 0.109000 3.49e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 96 6.57e-02 -0.109000 2.36e-01
KERATAN SULFATE DEGRADATION 12 5.14e-01 0.109000 7.60e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 2.74e-01 0.108000 5.42e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.34e-01 -0.108000 7.74e-01
MAP2K AND MAPK ACTIVATION 36 2.61e-01 0.108000 5.23e-01
MTOR SIGNALLING 41 2.30e-01 -0.108000 4.81e-01
PROLACTIN RECEPTOR SIGNALING 12 5.17e-01 0.108000 7.60e-01
EXTRACELLULAR MATRIX ORGANIZATION 247 3.52e-03 0.108000 3.40e-02
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 354 5.00e-04 -0.108000 8.54e-03
GABA RECEPTOR ACTIVATION 55 1.66e-01 0.108000 3.98e-01
AQUAPORIN MEDIATED TRANSPORT 42 2.27e-01 0.108000 4.78e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 4.07e-01 0.107000 6.64e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 3.36e-01 -0.107000 5.96e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 3.36e-01 -0.107000 5.96e-01
PLATELET AGGREGATION PLUG FORMATION 32 2.96e-01 0.107000 5.60e-01
DAP12 SIGNALING 24 3.66e-01 0.107000 6.23e-01
LAGGING STRAND SYNTHESIS 20 4.10e-01 -0.106000 6.67e-01
RNA POLYMERASE III CHAIN ELONGATION 18 4.35e-01 -0.106000 6.91e-01
METABOLISM OF COFACTORS 19 4.23e-01 -0.106000 6.81e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 5.24e-01 -0.106000 7.66e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 1.15e-01 -0.106000 3.23e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 3.26e-01 -0.105000 5.92e-01
FORMATION OF THE CORNIFIED ENVELOPE 26 3.52e-01 0.105000 6.07e-01
KERATINIZATION 26 3.52e-01 0.105000 6.07e-01
TELOMERE MAINTENANCE 77 1.13e-01 -0.105000 3.21e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 2.73e-01 -0.104000 5.41e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 3.42e-01 0.104000 6.01e-01
METABOLISM OF RNA 647 7.15e-06 -0.104000 3.67e-04
KILLING MECHANISMS 11 5.54e-01 0.103000 7.89e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.50e-01 -0.103000 7.06e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 5.21e-01 0.103000 7.64e-01
INTERLEUKIN 1 FAMILY SIGNALING 124 4.89e-02 -0.102000 1.96e-01
FCERI MEDIATED MAPK ACTIVATION 28 3.50e-01 -0.102000 6.07e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 4.95e-01 -0.102000 7.43e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 112 6.29e-02 -0.102000 2.29e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 2.62e-01 -0.101000 5.23e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 5.62e-01 -0.101000 7.96e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 5.14e-01 -0.101000 7.60e-01
CA DEPENDENT EVENTS 36 2.96e-01 0.101000 5.60e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 3.75e-01 -0.100000 6.34e-01
PCP CE PATHWAY 91 9.79e-02 -0.100000 2.92e-01
BIOLOGICAL OXIDATIONS 125 5.34e-02 -0.100000 2.07e-01
CELLULAR RESPONSE TO HEAT STRESS 95 9.57e-02 -0.099000 2.89e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 4.12e-01 -0.098800 6.69e-01
CD28 CO STIMULATION 31 3.42e-01 -0.098600 6.01e-01
INTERLEUKIN 17 SIGNALING 68 1.60e-01 -0.098600 3.88e-01
TOLL LIKE RECEPTOR CASCADES 141 4.35e-02 -0.098500 1.80e-01
JOSEPHIN DOMAIN DUBS 11 5.73e-01 -0.098100 8.03e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 4.08e-01 -0.097600 6.65e-01
PURINE CATABOLISM 16 5.00e-01 -0.097300 7.50e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 6.67e-02 0.097000 2.37e-01
NICOTINATE METABOLISM 25 4.02e-01 -0.096900 6.62e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 4.77e-01 0.096800 7.31e-01
RHO GTPASE CYCLE 427 6.44e-04 0.096500 9.74e-03
RHOBTB GTPASE CYCLE 35 3.24e-01 -0.096300 5.90e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 4.94e-01 0.095800 7.43e-01
DAP12 INTERACTIONS 31 3.57e-01 0.095600 6.11e-01
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.67e-01 -0.095600 3.98e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.08e-01 -0.095500 7.57e-01
PURINE SALVAGE 12 5.69e-01 -0.095000 8.02e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 92 1.16e-01 -0.094900 3.24e-01
ANCHORING FIBRIL FORMATION 14 5.41e-01 -0.094400 7.79e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 3.35e-01 0.094200 5.96e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 1.18e-01 0.092800 3.27e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 1.35e-01 -0.092800 3.53e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 6.12e-01 0.092800 8.25e-01
COLLAGEN DEGRADATION 51 2.52e-01 -0.092700 5.11e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 5.49e-01 -0.092600 7.85e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 3.24e-01 -0.092600 5.90e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 5.80e-01 -0.092300 8.07e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 5.98e-01 -0.091900 8.19e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 3.76e-01 0.091800 6.34e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 3.22e-01 0.091700 5.87e-01
CELL CELL COMMUNICATION 107 1.02e-01 0.091600 2.98e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 61 2.16e-01 -0.091600 4.71e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 64 2.06e-01 -0.091400 4.54e-01
INTERLEUKIN 27 SIGNALING 10 6.17e-01 0.091300 8.30e-01
COSTIMULATION BY THE CD28 FAMILY 51 2.61e-01 -0.091100 5.23e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 4.70e-01 -0.091000 7.23e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.29e-01 -0.090500 4.81e-01
SIGNALLING TO RAS 20 4.84e-01 0.090500 7.35e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 4.64e-01 -0.090300 7.17e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 3.70e-01 -0.090200 6.28e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 5.46e-01 -0.090100 7.83e-01
O LINKED GLYCOSYLATION 87 1.48e-01 0.089900 3.75e-01
LYSOSOME VESICLE BIOGENESIS 33 3.75e-01 -0.089300 6.34e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 4.31e-01 0.089100 6.89e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 166 4.80e-02 -0.089000 1.94e-01
THE PHOTOTRANSDUCTION CASCADE 21 4.80e-01 0.089000 7.33e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 5.51e-01 0.089000 7.86e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.57e-01 0.088900 3.87e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 5.65e-01 -0.088800 7.99e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 5.03e-01 0.088800 7.52e-01
METABOLISM OF FOLATE AND PTERINES 15 5.52e-01 -0.088700 7.87e-01
PLASMA LIPOPROTEIN CLEARANCE 27 4.25e-01 0.088700 6.83e-01
HS GAG BIOSYNTHESIS 30 4.03e-01 0.088300 6.62e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 6.30e-01 -0.088100 8.31e-01
SLC TRANSPORTER DISORDERS 78 1.79e-01 0.088100 4.15e-01
EXTENSION OF TELOMERES 49 2.88e-01 -0.087800 5.55e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 604 2.45e-04 -0.087700 5.02e-03
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 3.20e-01 -0.087700 5.86e-01
OLFACTORY SIGNALING PATHWAY 31 3.99e-01 0.087600 6.58e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 5.71e-01 -0.087500 8.02e-01
OPIOID SIGNALLING 87 1.59e-01 0.087400 3.88e-01
HIV TRANSCRIPTION ELONGATION 42 3.32e-01 -0.086500 5.94e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 5.04e-01 0.086300 7.52e-01
FERTILIZATION 13 5.91e-01 0.086200 8.15e-01
DNA REPAIR 289 1.19e-02 -0.086200 8.09e-02
PHOSPHOLIPID METABOLISM 187 4.29e-02 0.085900 1.79e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 5.92e-01 -0.085900 8.15e-01
MYOGENESIS 25 4.58e-01 0.085800 7.09e-01
AMINO ACIDS REGULATE MTORC1 51 2.90e-01 -0.085700 5.58e-01
SIGNALING BY NOTCH4 83 1.78e-01 -0.085600 4.14e-01
DNA STRAND ELONGATION 32 4.02e-01 -0.085500 6.62e-01
TRANSCRIPTIONAL REGULATION BY TP53 347 6.41e-03 -0.085300 5.39e-02
MEIOTIC RECOMBINATION 36 3.76e-01 -0.085200 6.34e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 4.52e-01 0.085200 7.06e-01
ADAPTIVE IMMUNE SYSTEM 617 3.23e-04 -0.085100 6.35e-03
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 3.04e-01 -0.084900 5.70e-01
DISEASES OF METABOLISM 200 3.91e-02 0.084700 1.66e-01
INSULIN RECEPTOR SIGNALLING CASCADE 45 3.30e-01 -0.084000 5.94e-01
GENERATION OF SECOND MESSENGER MOLECULES 20 5.16e-01 -0.083800 7.60e-01
PLATELET HOMEOSTASIS 77 2.04e-01 0.083800 4.52e-01
TRNA AMINOACYLATION 42 3.48e-01 -0.083600 6.07e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.31e-01 0.083600 8.32e-01
DNA DAMAGE RECOGNITION IN GG NER 38 3.75e-01 -0.083100 6.34e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 183 5.30e-02 0.083000 2.07e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 6.50e-01 -0.083000 8.41e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 6.05e-01 -0.083000 8.23e-01
MRNA SPLICING 188 5.06e-02 -0.082800 2.02e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 3.60e-01 0.082700 6.15e-01
ZINC TRANSPORTERS 16 5.70e-01 0.082000 8.02e-01
METABOLISM OF NUCLEOTIDES 92 1.75e-01 -0.081800 4.11e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 6.10e-01 0.081800 8.25e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 5.37e-01 -0.081800 7.76e-01
RHO GTPASE EFFECTORS 252 2.57e-02 -0.081700 1.30e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 4.98e-01 0.081700 7.46e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 5.28e-01 0.081600 7.69e-01
FGFR2 ALTERNATIVE SPLICING 25 4.80e-01 -0.081500 7.33e-01
CTLA4 INHIBITORY SIGNALING 20 5.28e-01 -0.081500 7.69e-01
SARS COV 1 INFECTION 48 3.30e-01 -0.081200 5.94e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 2.86e-01 -0.081000 5.54e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 46 3.42e-01 -0.081000 6.01e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 46 3.43e-01 -0.080800 6.01e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.19e-01 0.080700 5.84e-01
CIRCADIAN CLOCK 68 2.51e-01 0.080500 5.10e-01
TRP CHANNELS 20 5.35e-01 0.080200 7.74e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 5.02e-01 -0.079100 7.51e-01
SELECTIVE AUTOPHAGY 73 2.43e-01 -0.079000 5.00e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 4.06e-01 -0.078900 6.64e-01
LEISHMANIA INFECTION 201 5.49e-02 0.078600 2.08e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 5.98e-01 -0.078500 8.19e-01
MYD88 INDEPENDENT TLR4 CASCADE 94 1.90e-01 -0.078300 4.31e-01
DSCAM INTERACTIONS 11 6.53e-01 -0.078300 8.42e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 95 1.88e-01 -0.078200 4.29e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 3.83e-02 -0.078200 1.65e-01
INFLAMMASOMES 18 5.66e-01 -0.078200 7.99e-01
POLYMERASE SWITCHING 14 6.13e-01 -0.078100 8.26e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 5.77e-01 0.078100 8.05e-01
NUCLEAR SIGNALING BY ERBB4 31 4.52e-01 0.078100 7.06e-01
EUKARYOTIC TRANSLATION INITIATION 115 1.49e-01 -0.078000 3.76e-01
SIGNALING BY FGFR2 64 2.82e-01 -0.077800 5.50e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 93 1.95e-01 0.077800 4.39e-01
COPII MEDIATED VESICLE TRANSPORT 66 2.76e-01 -0.077600 5.45e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 55 3.21e-01 0.077400 5.86e-01
DISEASES OF PROGRAMMED CELL DEATH 53 3.31e-01 -0.077300 5.94e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 4.22e-01 -0.077300 6.81e-01
SIGNALING BY NOTCH 187 6.93e-02 0.077100 2.43e-01
RRNA PROCESSING 195 6.43e-02 -0.076900 2.32e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 6.19e-01 -0.076800 8.30e-01
POTASSIUM CHANNELS 91 2.06e-01 0.076700 4.54e-01
RHO GTPASES ACTIVATE CIT 18 5.76e-01 0.076100 8.04e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 6.22e-01 0.076100 8.30e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 36 4.30e-01 -0.075900 6.89e-01
COMPLEMENT CASCADE 28 4.89e-01 0.075600 7.40e-01
ACYL CHAIN REMODELLING OF PS 14 6.25e-01 -0.075400 8.30e-01
PLATELET CALCIUM HOMEOSTASIS 25 5.16e-01 0.075100 7.60e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 3.49e-01 -0.075100 6.07e-01
INITIAL TRIGGERING OF COMPLEMENT 13 6.40e-01 0.074800 8.38e-01
SODIUM CALCIUM EXCHANGERS 10 6.82e-01 0.074800 8.58e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 4.78e-01 -0.074800 7.33e-01
ION CHANNEL TRANSPORT 142 1.26e-01 0.074400 3.43e-01
LYSINE CATABOLISM 11 6.69e-01 -0.074400 8.49e-01
CHAPERONE MEDIATED AUTOPHAGY 21 5.56e-01 -0.074200 7.91e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 321 2.27e-02 -0.074100 1.22e-01
RHO GTPASES ACTIVATE PKNS 46 3.85e-01 -0.074000 6.41e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 16 6.09e-01 0.073900 8.25e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 6.57e-01 -0.073900 8.44e-01
ASSEMBLY OF THE HIV VIRION 16 6.11e-01 -0.073600 8.25e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 4.66e-01 -0.073400 7.18e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 5.10e-01 -0.073300 7.57e-01
SIGNALING BY SCF KIT 41 4.17e-01 0.073200 6.74e-01
AUTOPHAGY 140 1.35e-01 -0.073200 3.54e-01
SIGNALING BY RETINOIC ACID 34 4.60e-01 -0.073200 7.12e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 3.82e-01 -0.072900 6.39e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 5.37e-01 -0.072800 7.76e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.51e-01 -0.072400 8.42e-01
DUAL INCISION IN GG NER 40 4.29e-01 -0.072300 6.88e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.87e-01 0.072000 8.13e-01
HATS ACETYLATE HISTONES 92 2.33e-01 0.072000 4.87e-01
DISEASES OF IMMUNE SYSTEM 27 5.19e-01 -0.071700 7.62e-01
FOXO MEDIATED TRANSCRIPTION 59 3.43e-01 0.071400 6.01e-01
SIGNALING BY FGFR IN DISEASE 57 3.53e-01 -0.071200 6.07e-01
PROTEIN FOLDING 90 2.44e-01 -0.071100 5.01e-01
DEVELOPMENTAL BIOLOGY 830 5.59e-04 0.070900 8.98e-03
SNRNP ASSEMBLY 51 3.83e-01 -0.070700 6.39e-01
UB SPECIFIC PROCESSING PROTEASES 170 1.13e-01 -0.070600 3.20e-01
SHC1 EVENTS IN EGFR SIGNALING 11 6.86e-01 -0.070400 8.60e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 16 6.26e-01 -0.070400 8.30e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 5.43e-01 -0.070200 7.81e-01
HSF1 DEPENDENT TRANSACTIVATION 34 4.79e-01 -0.070100 7.33e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 6.74e-01 0.070100 8.52e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 4.93e-01 -0.070000 7.43e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 5.15e-01 0.069900 7.60e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 5.38e-01 0.069900 7.76e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 5.82e-01 0.069300 8.10e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 74 3.03e-01 -0.069300 5.69e-01
MITOTIC PROPHASE 93 2.49e-01 -0.069300 5.06e-01
STIMULI SENSING CHANNELS 76 2.97e-01 0.069300 5.60e-01
DEADENYLATION OF MRNA 25 5.49e-01 -0.069200 7.85e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 6.55e-01 -0.068900 8.44e-01
NEGATIVE REGULATION OF FLT3 14 6.56e-01 0.068800 8.44e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 3.15e-01 -0.068000 5.81e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 5.57e-01 -0.067800 7.92e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 79 2.98e-01 0.067800 5.61e-01
REGULATION OF SIGNALING BY CBL 22 5.83e-01 0.067500 8.10e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 7.00e-01 -0.067100 8.64e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 18 6.23e-01 -0.067000 8.30e-01
ERBB2 REGULATES CELL MOTILITY 14 6.67e-01 -0.066500 8.49e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 5.98e-01 0.066500 8.19e-01
DEUBIQUITINATION 244 7.71e-02 -0.065800 2.55e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 7.19e-01 0.065700 8.78e-01
RHO GTPASES ACTIVATE ROCKS 19 6.21e-01 -0.065500 8.30e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 6.62e-01 -0.065100 8.48e-01
EPHB MEDIATED FORWARD SIGNALING 42 4.68e-01 -0.064800 7.20e-01
SIGNALING BY ERBB2 48 4.38e-01 -0.064800 6.92e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 6.08e-01 -0.064700 8.25e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 6.64e-01 -0.064700 8.49e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 6.66e-01 -0.064400 8.49e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 6.03e-01 -0.064100 8.21e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 6.90e-01 -0.063800 8.60e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 5.59e-01 -0.063800 7.93e-01
REGULATION OF FZD BY UBIQUITINATION 19 6.33e-01 0.063400 8.32e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 96 2.85e-01 -0.063200 5.53e-01
ARACHIDONIC ACID METABOLISM 40 4.90e-01 -0.063200 7.40e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 180 1.45e-01 0.063100 3.72e-01
SIGNALING BY FGFR1 IN DISEASE 33 5.31e-01 0.063000 7.72e-01
RESOLUTION OF ABASIC SITES AP SITES 37 5.09e-01 -0.062700 7.57e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 286 6.96e-02 -0.062500 2.43e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 6.20e-01 -0.062400 8.30e-01
RNA POLYMERASE II TRANSCRIPTION 1102 5.20e-04 -0.062400 8.64e-03
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 6.05e-01 0.062300 8.23e-01
POLO LIKE KINASE MEDIATED EVENTS 13 6.98e-01 -0.062200 8.63e-01
HCMV LATE EVENTS 64 3.90e-01 -0.062100 6.48e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 5.85e-01 -0.062000 8.11e-01
TRIGLYCERIDE CATABOLISM 14 6.89e-01 -0.061900 8.60e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 62 4.04e-01 -0.061300 6.63e-01
HEMOSTASIS 475 2.29e-02 0.061100 1.22e-01
ACYL CHAIN REMODELLING OF PC 17 6.66e-01 0.060500 8.49e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 6.76e-01 -0.060300 8.53e-01
MET PROMOTES CELL MOTILITY 38 5.21e-01 0.060100 7.64e-01
INTERFERON GAMMA SIGNALING 80 3.54e-01 0.060000 6.07e-01
NICOTINAMIDE SALVAGING 15 6.88e-01 -0.059900 8.60e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 6.35e-01 0.059800 8.33e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 2.19e-01 -0.059800 4.74e-01
SIGNALING BY ERBB4 57 4.36e-01 0.059700 6.91e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 15 6.89e-01 0.059600 8.60e-01
METABOLISM OF CARBOHYDRATES 262 9.75e-02 0.059600 2.92e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 3.78e-01 -0.059300 6.36e-01
LAMININ INTERACTIONS 28 5.88e-01 0.059200 8.13e-01
CGMP EFFECTS 15 6.92e-01 0.059200 8.60e-01
CARDIAC CONDUCTION 109 2.88e-01 0.059000 5.55e-01
RHOJ GTPASE CYCLE 55 4.53e-01 0.058500 7.07e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 5.93e-01 -0.058400 8.16e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 7.16e-01 0.058300 8.76e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 7.27e-01 0.058100 8.81e-01
POTENTIAL THERAPEUTICS FOR SARS 77 3.80e-01 0.057900 6.39e-01
RHOD GTPASE CYCLE 51 4.77e-01 0.057600 7.31e-01
SIGNALING BY FGFR1 44 5.11e-01 -0.057300 7.58e-01
BASIGIN INTERACTIONS 22 6.43e-01 0.057100 8.40e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 6.44e-01 -0.056900 8.40e-01
INFLUENZA INFECTION 146 2.41e-01 -0.056300 4.98e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.06e-01 0.056200 8.70e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 7.39e-01 -0.055500 8.85e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 5.70e-01 0.055500 8.02e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 6.26e-01 -0.055300 8.30e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 5.72e-01 -0.055300 8.02e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 6.77e-01 -0.055300 8.53e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 6.69e-01 0.055200 8.49e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 7.51e-01 -0.055200 8.90e-01
TIE2 SIGNALING 17 6.94e-01 -0.055100 8.61e-01
INNATE IMMUNE SYSTEM 794 8.62e-03 -0.055100 6.55e-02
IRAK1 RECRUITS IKK COMPLEX 14 7.22e-01 0.055000 8.78e-01
AGGREPHAGY 35 5.76e-01 -0.054600 8.04e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 3.42e-01 0.054500 6.01e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 6.98e-01 0.054300 8.63e-01
ACTIVATION OF RAC1 13 7.35e-01 -0.054200 8.85e-01
NERVOUS SYSTEM DEVELOPMENT 554 2.98e-02 0.054200 1.46e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 6.83e-01 -0.054100 8.58e-01
HEDGEHOG ON STATE 84 3.93e-01 -0.054000 6.50e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 7.18e-01 -0.054000 8.77e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 6.71e-01 -0.053600 8.50e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1226 1.94e-03 -0.053000 2.18e-02
SIGNALING BY MET 74 4.33e-01 0.052700 6.89e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 3.85e-01 -0.052700 6.41e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 28 6.30e-01 -0.052700 8.31e-01
SIGNALING BY FGFR 75 4.31e-01 -0.052600 6.89e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 7.43e-01 0.052600 8.85e-01
P75NTR SIGNALS VIA NF KB 16 7.16e-01 0.052500 8.76e-01
GLYCOGEN STORAGE DISEASES 12 7.53e-01 0.052400 8.91e-01
NEUTROPHIL DEGRANULATION 394 7.53e-02 -0.052300 2.53e-01
TRIGLYCERIDE METABOLISM 24 6.59e-01 -0.052100 8.45e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 6.24e-01 -0.051800 8.30e-01
PI 3K CASCADE FGFR4 12 7.56e-01 0.051700 8.91e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 7.38e-01 0.051600 8.85e-01
MICRORNA MIRNA BIOGENESIS 24 6.62e-01 0.051600 8.48e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 7.21e-01 0.051600 8.78e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 7.33e-01 0.050800 8.85e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 63 4.86e-01 -0.050700 7.38e-01
BASE EXCISION REPAIR 55 5.17e-01 -0.050500 7.61e-01
UNWINDING OF DNA 12 7.62e-01 -0.050400 8.92e-01
NUCLEOBASE BIOSYNTHESIS 15 7.35e-01 -0.050400 8.85e-01
SIGNALING BY PDGFR IN DISEASE 20 6.98e-01 0.050100 8.63e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 5.75e-01 -0.050000 8.04e-01
PTEN REGULATION 138 3.12e-01 -0.049900 5.78e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 15 7.39e-01 0.049600 8.85e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 105 3.81e-01 0.049500 6.39e-01
O LINKED GLYCOSYLATION OF MUCINS 40 5.92e-01 0.049000 8.15e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 25 6.72e-01 -0.049000 8.51e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 5.09e-01 -0.048900 7.57e-01
CELLULAR RESPONSE TO STARVATION 147 3.10e-01 -0.048500 5.76e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 7.82e-01 -0.048300 9.00e-01
ION HOMEOSTASIS 49 5.60e-01 0.048200 7.93e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 7.74e-01 -0.047900 8.98e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 6.45e-01 -0.047800 8.40e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 6.30e-01 -0.047700 8.31e-01
ENOS ACTIVATION 11 7.87e-01 -0.047000 9.04e-01
VIRAL MESSENGER RNA SYNTHESIS 42 5.98e-01 -0.047000 8.19e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 222 2.30e-01 0.046800 4.81e-01
SIGNALING BY ROBO RECEPTORS 211 2.45e-01 -0.046500 5.01e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 7.40e-01 -0.046500 8.85e-01
MUSCLE CONTRACTION 164 3.07e-01 0.046300 5.72e-01
OXIDATIVE STRESS INDUCED SENESCENCE 77 4.83e-01 0.046300 7.35e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 5.22e-01 0.046300 7.64e-01
SIGNALING BY HEDGEHOG 143 3.41e-01 0.046100 6.01e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 7.94e-01 -0.045500 9.09e-01
RAC3 GTPASE CYCLE 91 4.55e-01 0.045300 7.08e-01
CALNEXIN CALRETICULIN CYCLE 26 6.93e-01 0.044800 8.61e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 6.12e-01 0.044800 8.25e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 7.57e-01 0.044600 8.91e-01
REGULATION OF TP53 ACTIVITY 155 3.40e-01 -0.044400 6.01e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 2.00e-01 -0.044200 4.47e-01
INWARDLY RECTIFYING K CHANNELS 32 6.66e-01 0.044100 8.49e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 8.01e-01 -0.044000 9.11e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 7.92e-01 -0.044000 9.08e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 7.11e-01 0.043700 8.73e-01
RAB REGULATION OF TRAFFICKING 118 4.14e-01 -0.043600 6.70e-01
PI 3K CASCADE FGFR3 13 7.86e-01 0.043500 9.04e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 6.89e-01 0.043000 8.60e-01
FANCONI ANEMIA PATHWAY 36 6.57e-01 -0.042700 8.44e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 6.25e-01 0.042600 8.30e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 5.47e-01 -0.042300 7.83e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 7.50e-01 0.042200 8.90e-01
SIGNALING BY NUCLEAR RECEPTORS 224 2.81e-01 0.041900 5.50e-01
SIGNALING BY NTRKS 130 4.13e-01 0.041700 6.69e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.44e-01 0.041200 8.40e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 8.22e-01 0.041200 9.23e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 7.14e-01 0.040700 8.76e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 8.24e-01 -0.040600 9.23e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 7.38e-01 0.040300 8.85e-01
NOD1 2 SIGNALING PATHWAY 35 6.80e-01 -0.040300 8.57e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 8.02e-01 0.040100 9.11e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 631 8.79e-02 0.040000 2.70e-01
REGULATION OF IFNG SIGNALING 13 8.04e-01 -0.039800 9.11e-01
TRANSPORT OF SMALL MOLECULES 590 1.01e-01 0.039700 2.97e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 7.16e-01 -0.039700 8.76e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 6.21e-01 -0.039700 8.30e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 7.27e-01 0.039600 8.81e-01
GOLGI TO ER RETROGRADE TRANSPORT 120 4.57e-01 -0.039300 7.09e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 6.49e-01 -0.039200 8.41e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.58e-01 0.038900 8.91e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 6.50e-01 -0.038700 8.41e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.17e-01 0.038600 9.23e-01
CARNITINE METABOLISM 14 8.03e-01 -0.038500 9.11e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 14 8.04e-01 0.038400 9.11e-01
LONG TERM POTENTIATION 23 7.51e-01 0.038300 8.90e-01
TRIGLYCERIDE BIOSYNTHESIS 10 8.34e-01 -0.038200 9.28e-01
RND1 GTPASE CYCLE 38 6.83e-01 0.038200 8.58e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.35e-01 -0.038100 9.28e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 56 6.26e-01 0.037600 8.30e-01
RNA POLYMERASE I TRANSCRIPTION 66 6.00e-01 -0.037400 8.20e-01
MISMATCH REPAIR 15 8.03e-01 -0.037200 9.11e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 7.03e-01 0.036700 8.68e-01
GPVI MEDIATED ACTIVATION CASCADE 31 7.24e-01 -0.036700 8.80e-01
PI METABOLISM 79 5.75e-01 0.036600 8.04e-01
VESICLE MEDIATED TRANSPORT 615 1.23e-01 -0.036500 3.38e-01
SIGNALING BY PDGF 57 6.35e-01 0.036300 8.33e-01
HCMV INFECTION 102 5.26e-01 -0.036300 7.68e-01
MEMBRANE TRAFFICKING 583 1.37e-01 -0.036200 3.56e-01
SIGNALING BY ACTIVIN 12 8.28e-01 0.036200 9.25e-01
INTERFERON SIGNALING 168 4.23e-01 0.035800 6.81e-01
INSULIN PROCESSING 24 7.62e-01 0.035700 8.92e-01
HIV ELONGATION ARREST AND RECOVERY 32 7.31e-01 0.035100 8.84e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 64 6.28e-01 -0.035100 8.31e-01
METABOLISM OF LIPIDS 615 1.45e-01 -0.034600 3.72e-01
MEIOSIS 63 6.36e-01 -0.034500 8.33e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 8.29e-01 0.034500 9.25e-01
RHOQ GTPASE CYCLE 59 6.47e-01 -0.034400 8.41e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 6.02e-01 -0.033900 8.21e-01
PLATELET SENSITIZATION BY LDL 15 8.22e-01 -0.033600 9.23e-01
SMOOTH MUSCLE CONTRACTION 33 7.43e-01 -0.033000 8.85e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 8.21e-01 -0.032700 9.23e-01
SURFACTANT METABOLISM 16 8.22e-01 0.032400 9.23e-01
RHO GTPASES ACTIVATE PAKS 21 7.98e-01 0.032200 9.11e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 85 6.08e-01 -0.032200 8.25e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 32 7.56e-01 0.031800 8.91e-01
INFECTIOUS DISEASE 737 1.45e-01 -0.031700 3.72e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 8.38e-01 0.031600 9.28e-01
DNA DOUBLE STRAND BREAK RESPONSE 51 6.97e-01 0.031500 8.63e-01
G PROTEIN BETA GAMMA SIGNALLING 31 7.62e-01 0.031500 8.92e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 97 5.97e-01 -0.031100 8.19e-01
SIGNALING BY INTERLEUKINS 355 3.18e-01 -0.030900 5.84e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 7.78e-01 0.030900 8.98e-01
TELOMERE EXTENSION BY TELOMERASE 22 8.03e-01 -0.030800 9.11e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 7.73e-01 0.030500 8.98e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 7.71e-01 -0.030200 8.98e-01
CELLULAR SENESCENCE 140 5.46e-01 0.029600 7.83e-01
SIGNALLING TO ERKS 34 7.66e-01 -0.029600 8.95e-01
NGF STIMULATED TRANSCRIPTION 36 7.61e-01 -0.029300 8.92e-01
NUCLEAR IMPORT OF REV PROTEIN 32 7.75e-01 -0.029200 8.98e-01
P38MAPK EVENTS 13 8.56e-01 -0.029100 9.38e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 8.62e-01 -0.029000 9.39e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 96 6.30e-01 -0.028500 8.31e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 7.74e-01 -0.028500 8.98e-01
RHOF GTPASE CYCLE 41 7.54e-01 0.028300 8.91e-01
ENDOSOMAL VACUOLAR PATHWAY 11 8.72e-01 -0.028000 9.45e-01
NUCLEOTIDE SALVAGE 21 8.25e-01 0.028000 9.23e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 21 8.26e-01 -0.027800 9.23e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 8.59e-01 0.027500 9.38e-01
GLYCOGEN METABOLISM 25 8.15e-01 0.027100 9.22e-01
GLUCOSE METABOLISM 81 6.74e-01 -0.027100 8.52e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 8.66e-01 -0.027100 9.42e-01
VLDLR INTERNALISATION AND DEGRADATION 12 8.71e-01 -0.027000 9.45e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 7.77e-01 -0.027000 8.98e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 8.78e-01 0.026600 9.49e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 7.29e-01 -0.026600 8.82e-01
OVARIAN TUMOR DOMAIN PROTEASES 37 7.80e-01 0.026500 9.00e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 7.67e-01 -0.026500 8.96e-01
SIGNALING BY ERBB2 IN CANCER 25 8.20e-01 -0.026300 9.23e-01
ERYTHROPOIETIN ACTIVATES RAS 13 8.74e-01 0.025400 9.46e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 7.68e-01 0.025400 8.97e-01
PEPTIDE HORMONE METABOLISM 60 7.34e-01 0.025400 8.85e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 107 6.52e-01 -0.025300 8.42e-01
RHOG GTPASE CYCLE 74 7.08e-01 0.025200 8.71e-01
ACYL CHAIN REMODELLING OF PE 17 8.57e-01 -0.025200 9.38e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 19 8.49e-01 -0.025200 9.34e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 8.63e-01 -0.024800 9.40e-01
SIGNALING BY FGFR3 35 8.01e-01 0.024600 9.11e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 8.94e-01 -0.024300 9.57e-01
INTEGRIN CELL SURFACE INTERACTIONS 74 7.22e-01 -0.024000 8.78e-01
EPH EPHRIN SIGNALING 92 6.92e-01 0.023900 8.60e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 8.50e-01 -0.023900 9.34e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 8.87e-01 -0.023800 9.55e-01
SELENOAMINO ACID METABOLISM 110 6.68e-01 -0.023700 8.49e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 8.92e-01 -0.023600 9.57e-01
TBC RABGAPS 43 7.92e-01 -0.023300 9.08e-01
SIGNALING BY FGFR4 33 8.19e-01 0.023000 9.23e-01
CELL CELL JUNCTION ORGANIZATION 49 7.81e-01 0.023000 9.00e-01
APOPTOTIC EXECUTION PHASE 45 7.97e-01 -0.022100 9.11e-01
PARASITE INFECTION 55 7.78e-01 -0.022000 8.98e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.91e-01 0.022000 9.57e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 8.47e-01 -0.021900 9.34e-01
SIGNALING BY CSF3 G CSF 29 8.39e-01 -0.021800 9.29e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 6.34e-01 -0.021100 8.33e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 9.09e-01 0.021000 9.63e-01
ESR MEDIATED SIGNALING 166 6.48e-01 0.020500 8.41e-01
SYNTHESIS OF PC 27 8.54e-01 0.020500 9.37e-01
PI3K AKT SIGNALING IN CANCER 90 7.41e-01 -0.020200 8.85e-01
GAP JUNCTION DEGRADATION 11 9.08e-01 0.020100 9.63e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 6.46e-01 -0.020000 8.41e-01
BILE ACID AND BILE SALT METABOLISM 24 8.67e-01 0.019800 9.42e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 9.03e-01 0.019500 9.63e-01
SIGNALING BY VEGF 104 7.36e-01 -0.019100 8.85e-01
NUCLEAR ENVELOPE BREAKDOWN 49 8.21e-01 0.018700 9.23e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 5.39e-01 0.018700 7.77e-01
DISEASES OF DNA REPAIR 11 9.15e-01 -0.018500 9.68e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 108 7.41e-01 -0.018500 8.85e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 288 5.91e-01 -0.018400 8.15e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 8.56e-01 -0.018300 9.38e-01
COLLAGEN FORMATION 81 7.77e-01 -0.018200 8.98e-01
FRS MEDIATED FGFR4 SIGNALING 14 9.06e-01 0.018200 9.63e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 20 8.89e-01 0.018000 9.56e-01
CELL JUNCTION ORGANIZATION 74 7.90e-01 0.017900 9.07e-01
RECYCLING PATHWAY OF L1 40 8.46e-01 -0.017700 9.34e-01
HEDGEHOG OFF STATE 108 7.51e-01 -0.017700 8.90e-01
METABOLISM OF VITAMINS AND COFACTORS 153 7.09e-01 0.017500 8.72e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 141 7.26e-01 0.017100 8.81e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 8.60e-01 -0.017000 9.38e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 8.93e-01 0.017000 9.57e-01
SIGNALING BY PTK6 50 8.36e-01 0.016900 9.28e-01
MAPK FAMILY SIGNALING CASCADES 290 6.21e-01 -0.016900 8.30e-01
CILIUM ASSEMBLY 193 6.87e-01 -0.016800 8.60e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 9.12e-01 -0.016500 9.66e-01
METABOLISM OF STEROIDS 114 7.62e-01 -0.016400 8.92e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 8.89e-01 -0.016400 9.56e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 9.25e-01 -0.016400 9.74e-01
INTRAFLAGELLAR TRANSPORT 52 8.43e-01 0.015800 9.32e-01
SARS COV INFECTIONS 140 7.50e-01 0.015600 8.90e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 9.23e-01 -0.015600 9.74e-01
STRIATED MUSCLE CONTRACTION 28 8.87e-01 0.015500 9.55e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 9.15e-01 0.015400 9.68e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 8.50e-01 0.015200 9.34e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 24 8.99e-01 0.014900 9.61e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 8.27e-01 -0.014900 9.25e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.85e-01 -0.014800 9.55e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 9.03e-01 -0.014700 9.63e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 9.07e-01 -0.014700 9.63e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 7.69e-01 -0.014700 8.97e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 8.62e-01 -0.014700 9.39e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 9.05e-01 0.014300 9.63e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 186 7.43e-01 -0.013900 8.85e-01
REPRODUCTION 76 8.35e-01 -0.013800 9.28e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 149 7.72e-01 -0.013800 8.98e-01
HCMV EARLY EVENTS 79 8.37e-01 0.013400 9.28e-01
FRS MEDIATED FGFR3 SIGNALING 15 9.29e-01 0.013300 9.77e-01
GLYCOLYSIS 67 8.50e-01 -0.013300 9.34e-01
GENE SILENCING BY RNA 81 8.36e-01 0.013300 9.28e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 9.03e-01 -0.013300 9.63e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 9.43e-01 -0.013000 9.84e-01
DNA METHYLATION 19 9.24e-01 -0.012600 9.74e-01
INTRA GOLGI TRAFFIC 43 8.96e-01 0.011500 9.59e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 9.46e-01 0.011400 9.84e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 102 8.42e-01 0.011400 9.32e-01
SARS COV 2 INFECTION 65 8.74e-01 -0.011400 9.46e-01
SIGNALING BY WNT 267 7.54e-01 0.011200 8.91e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 9.36e-01 0.011000 9.79e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 61 8.84e-01 0.010800 9.55e-01
RNA POLYMERASE III TRANSCRIPTION 41 9.06e-01 -0.010700 9.63e-01
VXPX CARGO TARGETING TO CILIUM 19 9.36e-01 0.010600 9.79e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 9.34e-01 0.010500 9.79e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 8.57e-01 -0.010300 9.38e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 9.46e-01 -0.009830 9.84e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 8.70e-01 0.009610 9.45e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.48e-01 -0.008430 9.85e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 9.63e-01 0.008110 9.96e-01
MEIOTIC SYNAPSIS 40 9.30e-01 0.007990 9.77e-01
LDL CLEARANCE 16 9.57e-01 0.007760 9.92e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 9.20e-01 0.007600 9.72e-01
BASE EXCISION REPAIR AP SITE FORMATION 28 9.45e-01 0.007550 9.84e-01
EGFR DOWNREGULATION 28 9.47e-01 -0.007320 9.84e-01
PRC2 METHYLATES HISTONES AND DNA 28 9.51e-01 -0.006720 9.87e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 467 8.20e-01 0.006150 9.23e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 9.35e-01 0.006150 9.79e-01
SIGNAL TRANSDUCTION BY L1 21 9.62e-01 0.006050 9.96e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 558 8.08e-01 -0.006030 9.15e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 9.75e-01 0.005750 9.97e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 9.29e-01 0.005300 9.77e-01
CROSSLINKING OF COLLAGEN FIBRILS 16 9.71e-01 -0.005170 9.97e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 9.72e-01 0.005160 9.97e-01
NONSENSE MEDIATED DECAY NMD 110 9.30e-01 -0.004870 9.77e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 9.42e-01 -0.004620 9.84e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 9.65e-01 0.004400 9.96e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 9.73e-01 0.004300 9.97e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 9.44e-01 0.004190 9.84e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.78e-01 -0.004070 9.97e-01
SIGNALING BY KIT IN DISEASE 20 9.77e-01 0.003650 9.97e-01
SIGNALING BY HIPPO 20 9.78e-01 0.003550 9.97e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.78e-01 0.003460 9.97e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.79e-01 0.003360 9.97e-01
AMYLOID FIBER FORMATION 56 9.66e-01 0.003310 9.96e-01
SPRY REGULATION OF FGF SIGNALING 16 9.82e-01 0.003240 9.98e-01
SHC MEDIATED CASCADE FGFR4 12 9.85e-01 0.003210 9.99e-01
ENDOGENOUS STEROLS 20 9.80e-01 -0.003190 9.97e-01
RAC2 GTPASE CYCLE 88 9.61e-01 0.003040 9.95e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 9.75e-01 0.002950 9.97e-01
HEME SIGNALING 45 9.75e-01 0.002750 9.97e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 9.76e-01 -0.002680 9.97e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 87 9.66e-01 -0.002640 9.96e-01
NUCLEOBASE CATABOLISM 31 9.80e-01 0.002600 9.97e-01
RHOH GTPASE CYCLE 37 9.80e-01 0.002330 9.97e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 60 9.78e-01 -0.002020 9.97e-01
SIGNALING BY EGFR IN CANCER 22 9.87e-01 0.001960 9.99e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 9.85e-01 0.001900 9.99e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 9.86e-01 -0.001790 9.99e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 9.90e-01 -0.001490 9.99e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 9.91e-01 0.001330 9.99e-01
SHC MEDIATED CASCADE FGFR3 13 9.94e-01 -0.001260 9.99e-01
PD 1 SIGNALING 10 9.95e-01 0.001150 9.99e-01
SIGNALING BY FGFR4 IN DISEASE 11 9.95e-01 -0.001080 9.99e-01
SIGNALING BY WNT IN CANCER 31 9.92e-01 0.001020 9.99e-01
CARGO CONCENTRATION IN THE ER 31 9.95e-01 -0.000657 9.99e-01
RETINOID CYCLE DISEASE EVENTS 10 9.97e-01 -0.000657 9.99e-01
EUKARYOTIC TRANSLATION ELONGATION 88 9.94e-01 -0.000443 9.99e-01
SCAVENGING BY CLASS A RECEPTORS 14 9.98e-01 -0.000395 9.99e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 9.96e-01 0.000370 9.99e-01
REGULATION OF PTEN GENE TRANSCRIPTION 60 9.96e-01 -0.000349 9.99e-01
SUMOYLATION 163 9.98e-01 0.000141 9.99e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.99e-01 0.000132 9.99e-01
CD209 DC SIGN SIGNALING 18 9.99e-01 0.000128 9.99e-01


Detailed Gene set reports



REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
set REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize 17
pANOVA 1.27e-05
s.dist 0.612
p.adjustANOVA 0.000553


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptpn11 9217
Ago2 8782
Mov10 8723
Src 8030
Tnrc6b 7817
Ago3 7793
Ago1 7429
Pml 7390
Runx1 7136
Ccnd2 6912
Cdk6 5286
Ccnd3 5012
Tnrc6c 4968
Tnrc6a 4642
Ago4 3113
Cbfb -1401
Ccnd1 -1418

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9217
Ago2 8782
Mov10 8723
Src 8030
Tnrc6b 7817
Ago3 7793
Ago1 7429
Pml 7390
Runx1 7136
Ccnd2 6912
Cdk6 5286
Ccnd3 5012
Tnrc6c 4968
Tnrc6a 4642
Ago4 3113
Cbfb -1401
Ccnd1 -1418


ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
set ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
setSize 10
pANOVA 0.00198
s.dist -0.565
p.adjustANOVA 0.0218


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cyb5r1 -7232
Hbb-bt -6893
Cyb5r4 -6627
Car2 -6573
Cyb5r2 -6026
Hba-a1 -5817
Hba-a2 -4805
Car4 -2795
Aqp1 -2554
Cyb5rl 5709

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cyb5r1 -7232
Hbb-bt -6893
Cyb5r4 -6627
Car2 -6573
Cyb5r2 -6026
Hba-a1 -5817
Hba-a2 -4805
Car4 -2795
Aqp1 -2554
Cyb5rl 5709


NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
set NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 11
pANOVA 0.00395
s.dist 0.502
p.adjustANOVA 0.0375


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hes5 8727
Notch2 8642
Mamld1 7116
Maml2 6129
Hes1 5681
Maml3 5250
Maml1 4761
Ep300 3953
Rbpj 2972
Fcer2a 2930
Creb1 -2268

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hes5 8727
Notch2 8642
Mamld1 7116
Maml2 6129
Hes1 5681
Maml3 5250
Maml1 4761
Ep300 3953
Rbpj 2972
Fcer2a 2930
Creb1 -2268


TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
set TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize 11
pANOVA 0.00469
s.dist -0.492
p.adjustANOVA 0.0429


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tlr3 -8114
Ctsk -6499
Lgmn -6323
Hsp90b1 -6220
Ctss -4522
Tlr7 -4014
Tlr9 -2783
Ctsb -2223
Ctsl -2111
Unc93b1 -1346
Cnpy3 3109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tlr3 -8114
Ctsk -6499
Lgmn -6323
Hsp90b1 -6220
Ctss -4522
Tlr7 -4014
Tlr9 -2783
Ctsb -2223
Ctsl -2111
Unc93b1 -1346
Cnpy3 3109


ADENYLATE CYCLASE ACTIVATING PATHWAY
set ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize 10
pANOVA 0.00791
s.dist 0.485
p.adjustANOVA 0.0621


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adcy6 8823
Adcy5 8013
Adcy4 7918
Adcy2 7684
Adcy3 4779
Adcy7 4460
Adcy9 3939
Adcy8 3833
Adcy1 -374
Gnal -1543

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8823
Adcy5 8013
Adcy4 7918
Adcy2 7684
Adcy3 4779
Adcy7 4460
Adcy9 3939
Adcy8 3833
Adcy1 -374
Gnal -1543


NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
set NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 20
pANOVA 0.000237
s.dist 0.475
p.adjustANOVA 0.00498


Top enriched genes
Top 20 genes
GeneID Gene Rank
Notch1 9000
Hes5 8727
Notch4 8678
Notch2 8642
Crebbp 7943
Mamld1 7116
Hey2 6508
Flt4 6177
Maml2 6129
Hes1 5681
Smad3 5364
Maml3 5250
Maml1 4761
Ep300 3953
Hey1 2989
Rbpj 2972
Snw1 1230
Kat2a -241
Acta2 -2739
Kat2b -4899

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 9000
Hes5 8727
Notch4 8678
Notch2 8642
Crebbp 7943
Mamld1 7116
Hey2 6508
Flt4 6177
Maml2 6129
Hes1 5681
Smad3 5364
Maml3 5250
Maml1 4761
Ep300 3953
Hey1 2989
Rbpj 2972
Snw1 1230
Kat2a -241
Acta2 -2739
Kat2b -4899


ACETYLCHOLINE REGULATES INSULIN SECRETION
set ACETYLCHOLINE REGULATES INSULIN SECRETION
setSize 10
pANOVA 0.00954
s.dist 0.473
p.adjustANOVA 0.0706


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gna11 9160
Gna15 8749
Gnaq 8710
Plcb3 7956
Plcb2 5797
Marcks 4851
Prkca 3941
Plcb1 776
Chrm3 -765
Gna14 -2655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gna11 9160
Gna15 8749
Gnaq 8710
Plcb3 7956
Plcb2 5797
Marcks 4851
Prkca 3941
Plcb1 776
Chrm3 -765
Gna14 -2655


A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
set A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize 26
pANOVA 6.85e-05
s.dist 0.451
p.adjustANOVA 0.00207


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gpc3 9165
Sdc4 9052
Ncan 8845
Cspg4 8711
Xylt2 8161
Gpc4 7881
Hspg2 7536
B4galt7 7467
B3gat2 6160
Sdc3 6010
Gpc5 5914
B3gat1 5348
Dcn 5144
Vcan 4233
Cspg5 4163
Xylt1 3990
B3galt6 3908
Gpc1 3241
Agrn 2429
Bgn 1800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpc3 9165
Sdc4 9052
Ncan 8845
Cspg4 8711
Xylt2 8161
Gpc4 7881
Hspg2 7536
B4galt7 7467
B3gat2 6160
Sdc3 6010
Gpc5 5914
B3gat1 5348
Dcn 5144
Vcan 4233
Cspg5 4163
Xylt1 3990
B3galt6 3908
Gpc1 3241
Agrn 2429
Bgn 1800
Gpc2 1789
B3gat3 63
Bcan -611
Sdc2 -744
Sdc1 -1206
Gpc6 -2625


RUNX3 REGULATES NOTCH SIGNALING
set RUNX3 REGULATES NOTCH SIGNALING
setSize 13
pANOVA 0.00487
s.dist 0.451
p.adjustANOVA 0.0438


Top enriched genes
Top 20 genes
GeneID Gene Rank
Jag1 9048
Notch1 9000
Crebbp 7943
Mamld1 7116
Maml2 6129
Hes1 5681
Maml3 5250
Maml1 4761
Ep300 3953
Rbpj 2972
Snw1 1230
Kat2a -241
Kat2b -4899

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Jag1 9048
Notch1 9000
Crebbp 7943
Mamld1 7116
Maml2 6129
Hes1 5681
Maml3 5250
Maml1 4761
Ep300 3953
Rbpj 2972
Snw1 1230
Kat2a -241
Kat2b -4899


DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
set DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
setSize 20
pANOVA 0.000559
s.dist 0.446
p.adjustANOVA 0.00898


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gpc3 9165
Sdc4 9052
Ncan 8845
Cspg4 8711
Gpc4 7881
Hspg2 7536
B4galt7 7467
Sdc3 6010
Gpc5 5914
Dcn 5144
Vcan 4233
Cspg5 4163
Gpc1 3241
Agrn 2429
Bgn 1800
Gpc2 1789
Bcan -611
Sdc2 -744
Sdc1 -1206
Gpc6 -2625

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpc3 9165
Sdc4 9052
Ncan 8845
Cspg4 8711
Gpc4 7881
Hspg2 7536
B4galt7 7467
Sdc3 6010
Gpc5 5914
Dcn 5144
Vcan 4233
Cspg5 4163
Gpc1 3241
Agrn 2429
Bgn 1800
Gpc2 1789
Bcan -611
Sdc2 -744
Sdc1 -1206
Gpc6 -2625


NOTCH HLH TRANSCRIPTION PATHWAY
set NOTCH HLH TRANSCRIPTION PATHWAY
setSize 28
pANOVA 4.99e-05
s.dist 0.443
p.adjustANOVA 0.00163


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hdac5 9082
Notch1 9000
Ncor2 8832
Ncor1 8768
Notch3 8741
Notch4 8678
Notch2 8642
Hdac8 8626
Hdac4 8281
Hdac11 7988
Crebbp 7943
Hdac6 7801
Mamld1 7116
Maml2 6129
Maml3 5250
Maml1 4761
Hdac10 4676
Rbpj 2972
Tbl1x 2492
Hdac1 1732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hdac5 9082
Notch1 9000
Ncor2 8832
Ncor1 8768
Notch3 8741
Notch4 8678
Notch2 8642
Hdac8 8626
Hdac4 8281
Hdac11 7988
Crebbp 7943
Hdac6 7801
Mamld1 7116
Maml2 6129
Maml3 5250
Maml1 4761
Hdac10 4676
Rbpj 2972
Tbl1x 2492
Hdac1 1732
Hdac7 1610
Snw1 1230
Hdac9 591
Tbl1xr1 124
Kat2a -241
Kat2b -4899
Hdac3 -6298
Hdac2 -6905


REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
set REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
setSize 10
pANOVA 0.017
s.dist 0.436
p.adjustANOVA 0.102


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dcc 8034
Src 8030
Slit1 7350
Ntn1 7137
Slit2 5404
Robo3 4621
Nell2 4195
Robo1 3861
Robo2 -1333
Slit3 -4019

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dcc 8034
Src 8030
Slit1 7350
Ntn1 7137
Slit2 5404
Robo3 4621
Nell2 4195
Robo1 3861
Robo2 -1333
Slit3 -4019


NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
set NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 23
pANOVA 0.000345
s.dist 0.431
p.adjustANOVA 0.00644


Top enriched genes
Top 20 genes
GeneID Gene Rank
Notch1 9000
Notch3 8741
Hes5 8727
Pbx1 8386
Crebbp 7943
Ikzf1 7836
Mamld1 7116
Heyl 6802
Wwc1 6736
Hey2 6508
Maml2 6129
Hes1 5681
Maml3 5250
Plxnd1 4928
Maml1 4761
Ep300 3953
Hey1 2989
Rbpj 2972
Snw1 1230
Kat2a -241

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 9000
Notch3 8741
Hes5 8727
Pbx1 8386
Crebbp 7943
Ikzf1 7836
Mamld1 7116
Heyl 6802
Wwc1 6736
Hey2 6508
Maml2 6129
Hes1 5681
Maml3 5250
Plxnd1 4928
Maml1 4761
Ep300 3953
Hey1 2989
Rbpj 2972
Snw1 1230
Kat2a -241
Kat2b -4899
Stat1 -5675
Fabp7 -6389


MITOCHONDRIAL TRANSLATION
set MITOCHONDRIAL TRANSLATION
setSize 93
pANOVA 7.17e-13
s.dist -0.43
p.adjustANOVA 4.23e-10


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptcd3 -7941
Mtif2 -7709
Mrpl47 -7704
Mrps2 -7666
Mrpl32 -7485
Mrpl42 -7443
Mrpl1 -7430
Mrpl3 -7426
Mrps30 -7390
Mrpl16 -7245
Mrps22 -7209
Mrpl50 -7046
Mrpl18 -6986
Mrps31 -6814
Mrrf -6753
Mrpl22 -6695
Mrpl40 -6638
Chchd1 -6051
Mrps14 -6019
Mrpl10 -5934

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptcd3 -7941
Mtif2 -7709
Mrpl47 -7704
Mrps2 -7666
Mrpl32 -7485
Mrpl42 -7443
Mrpl1 -7430
Mrpl3 -7426
Mrps30 -7390
Mrpl16 -7245
Mrps22 -7209
Mrpl50 -7046
Mrpl18 -6986
Mrps31 -6814
Mrrf -6753
Mrpl22 -6695
Mrpl40 -6638
Chchd1 -6051
Mrps14 -6019
Mrpl10 -5934
Mrpl15 -5924
Mrpl35 -5806
Mrps23 -5682
Mrpl34 -5574
Mrpl11 -5419
Mrpl13 -5402
Mrps36 -5052
Mrpl21 -4902
Mrpl48 -4801
Gfm1 -4711
Mrpl51 -4681
Mrpl30 -4674
Mrpl12 -4673
Mrpl46 -4656
Mrpl39 -4583
Mrpl36 -4541
Mrps33 -4470
Mrps35 -4401
Mrps18a -4385
Mrps27 -4340
Mrps18c -4308
Mrpl33 -4193
Mrpl43 -3990
Mrps12 -3768
Mrps18b -3658
Mrpl27 -3606
Mrpl49 -3508
Mrpl20 -3441
Mrpl37 -3397
Mrps10 -3265
Gfm2 -3140
Mrps9 -3000
Mrps21 -2986
Mrpl54 -2908
Mrpl17 -2834
Oxa1l -2551
Mrpl28 -2390
Gadd45gip1 -2283
Mrps7 -2250
Mrpl44 -2114
Mrpl19 -1979
Mrpl55 -1855
Mrpl53 -1767
Mrps24 -1708
Mrpl9 -1684
Mrpl57 -1564
Mrps11 -1389
Mrpl4 -1332
Mrps25 -1217
Mrpl52 -971
Tsfm -834
Mrps16 -823
Mrpl58 -790
Mrpl24 -683
Mrps17 -546
Mrpl41 -520
Mrps15 -424
Aurkaip1 -327
Mtif3 -259
Mrpl23 -195
Mrps28 -146
Tufm 589
Mtfmt 651
Mrps6 973
Mrps26 978
Mrpl2 1103
Mrps5 1311
Mrpl14 1675
Mrps34 1923
Mrpl38 4197
Eral1 4340
Dap3 5244
Mtrf1l 6443


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 6.18e-05
s.dist -0.43
p.adjustANOVA 0.00192


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ube2b -8104
Ube2w -8063
Ube2a -8007
Ube2g1 -8005
Uchl3 -7908
Ube2l3 -7760
Ube2d1 -7673
Ube2e1 -7615
Ube2d2a -7381
Ube2e3 -7217
Ube2k -7090
Uba6 -6486
Ube2t -6183
Ube2q2 -6098
Cdc34 -5031
Ube2s -3424
Usp9x -2843
Ube2r2 -2056
Ubb -2021
Rps27a -1713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2b -8104
Ube2w -8063
Ube2a -8007
Ube2g1 -8005
Uchl3 -7908
Ube2l3 -7760
Ube2d1 -7673
Ube2e1 -7615
Ube2d2a -7381
Ube2e3 -7217
Ube2k -7090
Uba6 -6486
Ube2t -6183
Ube2q2 -6098
Cdc34 -5031
Ube2s -3424
Usp9x -2843
Ube2r2 -2056
Ubb -2021
Rps27a -1713
Usp7 -1295
Otulin 780
Ubc 799
Uba1 2537
Ube2z 3126
Usp5 3552
Uba52 5453
Ube2g2 6059
Ube2h 7331


P75NTR REGULATES AXONOGENESIS
set P75NTR REGULATES AXONOGENESIS
setSize 10
pANOVA 0.0196
s.dist -0.426
p.adjustANOVA 0.113


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mcf2 -8127
Omg -7606
Rtn4 -5978
Ngf -5724
Rhoa -5055
Rtn4r -4848
Mag -3668
Lingo1 243
Ngfr 782
Arhgdia 8394

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mcf2 -8127
Omg -7606
Rtn4 -5978
Ngf -5724
Rhoa -5055
Rtn4r -4848
Mag -3668
Lingo1 243
Ngfr 782
Arhgdia 8394


TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
set TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
setSize 19
pANOVA 0.00133
s.dist 0.425
p.adjustANOVA 0.0163


Top enriched genes
Top 20 genes
GeneID Gene Rank
Epas1 9188
Stat3 8848
Nr5a1 8818
Hif3a 8482
Fgf2 8389
Pbx1 8386
Epha1 6598
Sall1 6239
Klf4 4300
Nr6a1 4084
Foxp1 3749
Sox2 3506
Foxd3 2758
Smad4 2274
Smad2 403
Hhex 342
Eomes -1675
Zic3 -1749
Tsc22d1 -2503

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Epas1 9188
Stat3 8848
Nr5a1 8818
Hif3a 8482
Fgf2 8389
Pbx1 8386
Epha1 6598
Sall1 6239
Klf4 4300
Nr6a1 4084
Foxp1 3749
Sox2 3506
Foxd3 2758
Smad4 2274
Smad2 403
Hhex 342
Eomes -1675
Zic3 -1749
Tsc22d1 -2503


YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
set YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
setSize 12
pANOVA 0.0141
s.dist 0.409
p.adjustANOVA 0.0913


Top enriched genes
Top 20 genes
GeneID Gene Rank
Hipk1 9091
Hipk2 9004
Tead2 8426
Tead3 7941
Tead1 7356
Yap1 6918
Runx2 6640
Tead4 5838
Ccn2 3393
Nppa -3846
Kat2b -4899
Wwtr1 -6716

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hipk1 9091
Hipk2 9004
Tead2 8426
Tead3 7941
Tead1 7356
Yap1 6918
Runx2 6640
Tead4 5838
Ccn2 3393
Nppa -3846
Kat2b -4899
Wwtr1 -6716


CRISTAE FORMATION
set CRISTAE FORMATION
setSize 31
pANOVA 8.17e-05
s.dist -0.409
p.adjustANOVA 0.00231


Top enriched genes
Top 20 genes
GeneID Gene Rank
Apoo -8125
Dmac2l -7964
Atp5c1 -7957
Mtx2 -7802
Atp5pb -7748
Apool -6643
Atp5o -6217
Atp5l -6123
Atp5h -5528
Atp5b -5445
Chchd3 -5372
Immt -5219
mt-Atp6 -4709
Micos10 -4071
Atp5g3 -3713
Atp5a1 -3491
Micos13 -2873
Hspa9 -2569
Atp5j2 -2337
Tmem11 -2125

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Apoo -8125
Dmac2l -7964
Atp5c1 -7957
Mtx2 -7802
Atp5pb -7748
Apool -6643
Atp5o -6217
Atp5l -6123
Atp5h -5528
Atp5b -5445
Chchd3 -5372
Immt -5219
mt-Atp6 -4709
Micos10 -4071
Atp5g3 -3713
Atp5a1 -3491
Micos13 -2873
Hspa9 -2569
Atp5j2 -2337
Tmem11 -2125
Atp5d -1655
Atp5j -1397
Chchd6 -299
Samm50 145
Mtx1 281
Atp5g1 399
Atp5g2 802
Atp5e 1074
Atp5k 2319
Dnajc11 2941
mt-Atp8 8363


REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS
set REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS
setSize 15
pANOVA 0.00625
s.dist 0.408
p.adjustANOVA 0.053


Top enriched genes
Top 20 genes
GeneID Gene Rank
Notch1 9000
Crebbp 7943
Mamld1 7116
Maml2 6129
Onecut1 6086
Hes1 5681
Maml3 5250
Maml1 4761
Ep300 3953
Onecut3 3422
Rbpj 2972
Hnf1b 2822
Snw1 1230
Kat2a -241
Kat2b -4899

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 9000
Crebbp 7943
Mamld1 7116
Maml2 6129
Onecut1 6086
Hes1 5681
Maml3 5250
Maml1 4761
Ep300 3953
Onecut3 3422
Rbpj 2972
Hnf1b 2822
Snw1 1230
Kat2a -241
Kat2b -4899


FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
set FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize 19
pANOVA 0.00252
s.dist -0.4
p.adjustANOVA 0.0268


Top enriched genes
Top 20 genes
GeneID Gene Rank
Tuba8 -7124
Cct6a -6800
Tcp1 -6718
Tuba4a -6705
Cct4 -6510
Tubb4b -6351
Tuba1b -5488
Cct7 -5441
Cct2 -5397
Tuba1c -4837
Cct8 -4493
Tubb3 -3836
Cct5 -3394
Cct3 -1065
Tuba1a 676
Tubb4a 976
Tubb6 5059
Tubb2a 5533
Tubb2b 6234

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tuba8 -7124
Cct6a -6800
Tcp1 -6718
Tuba4a -6705
Cct4 -6510
Tubb4b -6351
Tuba1b -5488
Cct7 -5441
Cct2 -5397
Tuba1c -4837
Cct8 -4493
Tubb3 -3836
Cct5 -3394
Cct3 -1065
Tuba1a 676
Tubb4a 976
Tubb6 5059
Tubb2a 5533
Tubb2b 6234


SIGNALING BY LEPTIN
set SIGNALING BY LEPTIN
setSize 10
pANOVA 0.0284
s.dist 0.4
p.adjustANOVA 0.143


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptpn11 9217
Stat3 8848
Stat5b 8265
Sh2b1 8204
Irs2 2955
Irs1 1960
Socs3 1333
Jak2 418
Lepr 33
Stat5a -1061

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9217
Stat3 8848
Stat5b 8265
Sh2b1 8204
Irs2 2955
Irs1 1960
Socs3 1333
Jak2 418
Lepr 33
Stat5a -1061


NR1H2 AND NR1H3 MEDIATED SIGNALING
set NR1H2 AND NR1H3 MEDIATED SIGNALING
setSize 38
pANOVA 2.39e-05
s.dist 0.396
p.adjustANOVA 0.000939


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rxra 9069
Srebf1 8894
Ncor2 8832
Ago2 8782
Ncor1 8768
Mov10 8723
Kdm4a 8057
Tnrc6b 7817
Ago3 7793
Ago1 7429
Fasn 7244
Apoe 6652
Scd2 6105
Gps2 6006
Scd1 5871
Pltp 5738
Abca1 5682
Abcg1 5252
Tnrc6c 4968
Tnrc6a 4642

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rxra 9069
Srebf1 8894
Ncor2 8832
Ago2 8782
Ncor1 8768
Mov10 8723
Kdm4a 8057
Tnrc6b 7817
Ago3 7793
Ago1 7429
Fasn 7244
Apoe 6652
Scd2 6105
Gps2 6006
Scd1 5871
Pltp 5738
Abca1 5682
Abcg1 5252
Tnrc6c 4968
Tnrc6a 4642
Eepd1 3999
Ep300 3953
Nr1h3 3744
Kdm3a 3245
Ago4 3113
Ncoa1 2652
Rxrb 2498
Tbl1x 2492
Mylip 1690
Kdm1b 493
Tbl1xr1 124
Nr1h2 -29
Kdm1a -813
Apoc1 -836
Arl4c -2398
Apod -3649
Nrip1 -5247
Hdac3 -6298


NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
set NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
setSize 32
pANOVA 0.000117
s.dist 0.393
p.adjustANOVA 0.00315


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rxra 9069
Ncor2 8832
Ago2 8782
Ncor1 8768
Mov10 8723
Kdm4a 8057
Tnrc6b 7817
Ago3 7793
Ago1 7429
Apoe 6652
Gps2 6006
Pltp 5738
Abca1 5682
Abcg1 5252
Tnrc6c 4968
Tnrc6a 4642
Eepd1 3999
Ep300 3953
Nr1h3 3744
Kdm3a 3245

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rxra 9069
Ncor2 8832
Ago2 8782
Ncor1 8768
Mov10 8723
Kdm4a 8057
Tnrc6b 7817
Ago3 7793
Ago1 7429
Apoe 6652
Gps2 6006
Pltp 5738
Abca1 5682
Abcg1 5252
Tnrc6c 4968
Tnrc6a 4642
Eepd1 3999
Ep300 3953
Nr1h3 3744
Kdm3a 3245
Ago4 3113
Ncoa1 2652
Rxrb 2498
Tbl1x 2492
Kdm1b 493
Tbl1xr1 124
Nr1h2 -29
Kdm1a -813
Apoc1 -836
Arl4c -2398
Apod -3649
Hdac3 -6298


INTERLEUKIN 6 SIGNALING
set INTERLEUKIN 6 SIGNALING
setSize 10
pANOVA 0.0318
s.dist 0.392
p.adjustANOVA 0.151


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ptpn11 9217
Stat3 8848
Il6st 8447
Cbl 8344
Il6ra 6905
Tyk2 5688
Socs3 1333
Jak2 418
Jak1 -4066
Stat1 -5675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9217
Stat3 8848
Il6st 8447
Cbl 8344
Il6ra 6905
Tyk2 5688
Socs3 1333
Jak2 418
Jak1 -4066
Stat1 -5675


FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
set FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize 18
pANOVA 0.00407
s.dist -0.391
p.adjustANOVA 0.0384


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dmac2l -7964
Atp5c1 -7957
Atp5pb -7748
Atp5o -6217
Atp5l -6123
Atp5h -5528
Atp5b -5445
mt-Atp6 -4709
Atp5g3 -3713
Atp5a1 -3491
Atp5j2 -2337
Atp5d -1655
Atp5j -1397
Atp5g1 399
Atp5g2 802
Atp5e 1074
Atp5k 2319
mt-Atp8 8363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dmac2l -7964
Atp5c1 -7957
Atp5pb -7748
Atp5o -6217
Atp5l -6123
Atp5h -5528
Atp5b -5445
mt-Atp6 -4709
Atp5g3 -3713
Atp5a1 -3491
Atp5j2 -2337
Atp5d -1655
Atp5j -1397
Atp5g1 399
Atp5g2 802
Atp5e 1074
Atp5k 2319
mt-Atp8 8363


APOPTOSIS INDUCED DNA FRAGMENTATION
set APOPTOSIS INDUCED DNA FRAGMENTATION
setSize 10
pANOVA 0.0347
s.dist -0.386
p.adjustANOVA 0.156


Top enriched genes
Top 20 genes
GeneID Gene Rank
H1f0 -7564
Kpna1 -6674
Hmgb1 -5676
H1f2 -3906
Hmgb2 -3803
Dffb -3577
Dffa -3401
Casp3 -1259
H1f4 3453
Kpnb1 4356

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H1f0 -7564
Kpna1 -6674
Hmgb1 -5676
H1f2 -3906
Hmgb2 -3803
Dffb -3577
Dffa -3401
Casp3 -1259
H1f4 3453
Kpnb1 4356


E2F MEDIATED REGULATION OF DNA REPLICATION
set E2F MEDIATED REGULATION OF DNA REPLICATION
setSize 20
pANOVA 0.00309
s.dist -0.382
p.adjustANOVA 0.0312


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ppp2cb -8037
Orc5 -8018
Orc4 -8011
Orc6 -7650
Prim1 -7143
Ppp2ca -6585
Rb1 -5022
Orc3 -4891
Cdk1 -4539
Pola2 -4313
Orc2 -3312
Tfdp2 -2763
Ppp2r1a -1578
Pola1 -568
E2f1 -285
Mcm8 1092
Tfdp1 3192
Prim2 3600
Ppp2r1b 4013
Ppp2r3d 5363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2cb -8037
Orc5 -8018
Orc4 -8011
Orc6 -7650
Prim1 -7143
Ppp2ca -6585
Rb1 -5022
Orc3 -4891
Cdk1 -4539
Pola2 -4313
Orc2 -3312
Tfdp2 -2763
Ppp2r1a -1578
Pola1 -568
E2f1 -285
Mcm8 1092
Tfdp1 3192
Prim2 3600
Ppp2r1b 4013
Ppp2r3d 5363


RESPIRATORY ELECTRON TRANSPORT
set RESPIRATORY ELECTRON TRANSPORT
setSize 102
pANOVA 2.92e-11
s.dist -0.381
p.adjustANOVA 8.61e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cycs -8030
Ndufaf4 -7868
mt-Co2 -7682
Ndufv2 -7656
Ndufaf1 -7469
Cox16 -7133
Ndufaf5 -7082
Uqcrc2 -6944
Ndufa10 -6620
Ndufs8 -6346
Etfa -6345
Ndufb5 -6247
Uqcrfs1 -6242
Coq10b -6237
Sco1 -6175
Sdhb -6142
Ndufs4 -6002
Ndufab1 -5907
Ndufaf2 -5871
Cox5a -5848

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8030
Ndufaf4 -7868
mt-Co2 -7682
Ndufv2 -7656
Ndufaf1 -7469
Cox16 -7133
Ndufaf5 -7082
Uqcrc2 -6944
Ndufa10 -6620
Ndufs8 -6346
Etfa -6345
Ndufb5 -6247
Uqcrfs1 -6242
Coq10b -6237
Sco1 -6175
Sdhb -6142
Ndufs4 -6002
Ndufab1 -5907
Ndufaf2 -5871
Cox5a -5848
Ndufc2 -5708
mt-Nd6 -5663
Ndufs1 -5656
Ndufaf6 -5594
Cox7b -5578
Ndufb6 -5473
mt-Co3 -5281
Ndufb10 -5238
Ndufs3 -5124
Etfdh -4906
mt-Nd1 -4844
mt-Nd2 -4781
Ndufb11 -4773
Ndufa11 -4644
Cyc1 -4449
Ndufs5 -4413
Cox6b1 -4382
Ndufa4 -4298
Cox14 -4210
Nubpl -4196
Ndufa9 -4089
Coq10a -4069
mt-Nd4 -3966
Uqcrh -3955
Ndufb2 -3710
Uqcrb -3701
Ndufb8 -3628
mt-Cytb -3524
Ndufb3 -3471
Ndufb9 -3216
Ndufc1 -3162
Surf1 -3105
Ndufa5 -2848
Sdhd -2734
Acad9 -2499
Tmem126b -2435
Cox7a2l -2393
Cox6a1 -2388
mt-Co1 -2373
Taco1 -2353
Lrpprc -2267
Uqcrc1 -2164
Cox4i1 -2090
Cox7c -2027
Ndufv1 -1902
mt-Nd5 -1899
Ndufb4 -1843
Sdhc -1459
Cox20 -1000
Cox6c -980
Ndufa1 -976
Ndufa8 -890
Cox11 -886
Trap1 -877
Ecsit -799
Ndufa6 -730
Ndufs2 -313
Uqcrq -45
Sco2 -39
Timmdc1 127
Ndufa2 192
Ndufb1 288
Ndufb7 526
Ndufv3 528
Ndufs7 540
Ndufa7 677
Ndufa12 818
Etfb 929
Ndufs6 970
Uqcr10 1018
Uqcr11 1032
Cox19 1233
Cox5b 1282
Sdha 1613
Ndufaf3 1638
Cox18 1693
Ndufa3 2456
Cox8a 2988
Ndufa13 3399
Ndufaf7 4178
mt-Nd3 4619
Tmem186 6798


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 11
pANOVA 0.029
s.dist -0.38
p.adjustANOVA 0.144


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ywhaq -7492
Chek1 -6894
Ywhab -5371
Ywhah -4974
Cdk1 -4539
Wee1 -3599
Ywhae -3460
Ywhaz -2940
Chek2 -1870
Ywhag 3512
Sfn 7283

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ywhaq -7492
Chek1 -6894
Ywhab -5371
Ywhah -4974
Cdk1 -4539
Wee1 -3599
Ywhae -3460
Ywhaz -2940
Chek2 -1870
Ywhag 3512
Sfn 7283


ASPARTATE AND ASPARAGINE METABOLISM
set ASPARTATE AND ASPARAGINE METABOLISM
setSize 11
pANOVA 0.0291
s.dist -0.38
p.adjustANOVA 0.144


Top enriched genes
Top 20 genes
GeneID Gene Rank
Aspa -7827
Folh1 -6997
Asns -6373
Slc25a13 -5110
Got1 -4041
Got2 -3412
Gadl1 -1112
Nat8l -572
Slc25a12 1
Naalad2 1185
Aspg 3952

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aspa -7827
Folh1 -6997
Asns -6373
Slc25a13 -5110
Got1 -4041
Got2 -3412
Gadl1 -1112
Nat8l -572
Slc25a12 1
Naalad2 1185
Aspg 3952


PHASE 2 PLATEAU PHASE
set PHASE 2 PLATEAU PHASE
setSize 12
pANOVA 0.0227
s.dist 0.38
p.adjustANOVA 0.122


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cacng4 9125
Kcne4 8641
Cacng8 8296
Akap9 8139
Cacna1c 6957
Cacnb1 6816
Cacna2d2 3396
Cacng7 2834
Kcne1l 1055
Cacnb2 337
Kcne2 -3118
Kcnq1 -6400

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cacng4 9125
Kcne4 8641
Cacng8 8296
Akap9 8139
Cacna1c 6957
Cacnb1 6816
Cacna2d2 3396
Cacng7 2834
Kcne1l 1055
Cacnb2 337
Kcne2 -3118
Kcnq1 -6400


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 0.000978
s.dist -0.374
p.adjustANOVA 0.0133


Top enriched genes
Top 20 genes
GeneID Gene Rank
Vbp1 -7976
Pfdn4 -7847
Tuba8 -7124
Cct6a -6800
Tcp1 -6718
Tuba4a -6705
Cct4 -6510
Tubb4b -6351
Tuba1b -5488
Cct7 -5441
Cct2 -5397
Tuba1c -4837
Cct8 -4493
Tubb3 -3836
Pfdn1 -3799
Cct5 -3394
Pfdn6 -1705
Cct3 -1065
Tuba1a 676
Tubb4a 976

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Vbp1 -7976
Pfdn4 -7847
Tuba8 -7124
Cct6a -6800
Tcp1 -6718
Tuba4a -6705
Cct4 -6510
Tubb4b -6351
Tuba1b -5488
Cct7 -5441
Cct2 -5397
Tuba1c -4837
Cct8 -4493
Tubb3 -3836
Pfdn1 -3799
Cct5 -3394
Pfdn6 -1705
Cct3 -1065
Tuba1a 676
Tubb4a 976
Pfdn5 1529
Actb 1819
Pfdn2 3534
Tubb6 5059
Tubb2a 5533
Tubb2b 6234


COMPLEX I BIOGENESIS
set COMPLEX I BIOGENESIS
setSize 56
pANOVA 1.97e-06
s.dist -0.367
p.adjustANOVA 0.000116


Top enriched genes
Top 20 genes
GeneID Gene Rank
Ndufaf4 -7868
Ndufv2 -7656
Ndufaf1 -7469
Ndufaf5 -7082
Ndufa10 -6620
Ndufs8 -6346
Ndufb5 -6247
Ndufs4 -6002
Ndufab1 -5907
Ndufaf2 -5871
Ndufc2 -5708
mt-Nd6 -5663
Ndufs1 -5656
Ndufaf6 -5594
Ndufb6 -5473
Ndufb10 -5238
Ndufs3 -5124
mt-Nd1 -4844
mt-Nd2 -4781
Ndufb11 -4773

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufaf4 -7868
Ndufv2 -7656
Ndufaf1 -7469
Ndufaf5 -7082
Ndufa10 -6620
Ndufs8 -6346
Ndufb5 -6247
Ndufs4 -6002
Ndufab1 -5907
Ndufaf2 -5871
Ndufc2 -5708
mt-Nd6 -5663
Ndufs1 -5656
Ndufaf6 -5594
Ndufb6 -5473
Ndufb10 -5238
Ndufs3 -5124
mt-Nd1 -4844
mt-Nd2 -4781
Ndufb11 -4773
Ndufa11 -4644
Ndufs5 -4413
Nubpl -4196
Ndufa9 -4089
mt-Nd4 -3966
Ndufb2 -3710
Ndufb8 -3628
Ndufb3 -3471
Ndufb9 -3216
Ndufc1 -3162
Ndufa5 -2848
Acad9 -2499
Tmem126b -2435
Ndufv1 -1902
mt-Nd5 -1899
Ndufb4 -1843
Ndufa1 -976
Ndufa8 -890
Ecsit -799
Ndufa6 -730
Ndufs2 -313
Timmdc1 127
Ndufa2 192
Ndufb1 288
Ndufb7 526
Ndufv3 528
Ndufs7 540
Ndufa7 677
Ndufa12 818
Ndufs6 970
Ndufaf3 1638
Ndufa3 2456
Ndufa13 3399
Ndufaf7 4178
mt-Nd3 4619
Tmem186 6798


DEFECTIVE EXT2 CAUSES EXOSTOSES 2
set DEFECTIVE EXT2 CAUSES EXOSTOSES 2
setSize 14
pANOVA 0.0174
s.dist 0.367
p.adjustANOVA 0.103


Top enriched genes
Top 20 genes
GeneID Gene Rank
Gpc3 9165
Sdc4 9052
Gpc4 7881
Hspg2 7536
Sdc3 6010
Gpc5 5914
Ext2 4930
Gpc1 3241
Agrn 2429
Gpc2 1789
Sdc2 -744
Ext1 -1182
Sdc1 -1206
Gpc6 -2625

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpc3 9165
Sdc4 9052
Gpc4 7881
Hspg2 7536
Sdc3 6010
Gpc5 5914
Ext2 4930
Gpc1 3241
Agrn 2429
Gpc2 1789
Sdc2 -744
Ext1 -1182
Sdc1 -1206
Gpc6 -2625


ACTIVATION OF SMO
set ACTIVATION OF SMO
setSize 16
pANOVA 0.0112
s.dist 0.366
p.adjustANOVA 0.0785


Top enriched genes
Top 20 genes
GeneID Gene Rank
Arrb1 9184
Evc 8994
Gas8 8539
Smo 7050
Iqce 6499
Ptch1 6101
Kif3a 6078
Cdon 4384
Arrb2 3726
Evc2 3421
Grk2 2590
Efcab7 273
Boc -49
Gas1 -76
Shh -768
Csnk1a1 -6442

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Arrb1 9184
Evc 8994
Gas8 8539
Smo 7050
Iqce 6499
Ptch1 6101
Kif3a 6078
Cdon 4384
Arrb2 3726
Evc2 3421
Grk2 2590
Efcab7 273
Boc -49
Gas1 -76
Shh -768
Csnk1a1 -6442


TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
set TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
setSize 13
pANOVA 0.0227
s.dist 0.365
p.adjustANOVA 0.122


Top enriched genes
Top 20 genes
GeneID Gene Rank
Traf3 8937
Mavs 8898
Crebbp 7943
Irf3 6743
Sike1 6198
Ikbke 5565
Ep300 3953
Ddx58 2910
Rnf135 1572
Ifih1 1500
Irf7 442
Trim25 -926
Tbk1 -5510

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Traf3 8937
Mavs 8898
Crebbp 7943
Irf3 6743
Sike1 6198
Ikbke 5565
Ep300 3953
Ddx58 2910
Rnf135 1572
Ifih1 1500
Irf7 442
Trim25 -926
Tbk1 -5510


INTERACTION BETWEEN L1 AND ANKYRINS
set INTERACTION BETWEEN L1 AND ANKYRINS
setSize 27
pANOVA 0.00103
s.dist 0.365
p.adjustANOVA 0.0137


Top enriched genes
Top 20 genes
GeneID Gene Rank
Scn5a 8331
Sptbn4 8119
Sptbn5 7958
Scn2b 7942
Sptbn1 7676
Scn3b 7517
Scn3a 7340
Nfasc 7216
Ank2 7087
Kcnq2 7048
Kcnq3 6354
Sptbn2 6244
L1cam 5046
Scn7a 4957
Sptan1 4941
Scn2a 4477
Sptb 4397
Scn9a 2523
Actb 1819
Ank3 1757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Scn5a 8331
Sptbn4 8119
Sptbn5 7958
Scn2b 7942
Sptbn1 7676
Scn3b 7517
Scn3a 7340
Nfasc 7216
Ank2 7087
Kcnq2 7048
Kcnq3 6354
Sptbn2 6244
L1cam 5046
Scn7a 4957
Sptan1 4941
Scn2a 4477
Sptb 4397
Scn9a 2523
Actb 1819
Ank3 1757
Scn8a 876
Nrcam 501
Ank1 292
Scn4b -4562
Actg1 -4826
Scn1a -5330
Scn1b -5621


CITRIC ACID CYCLE TCA CYCLE
set CITRIC ACID CYCLE TCA CYCLE
setSize 22
pANOVA 0.00316
s.dist -0.364
p.adjustANOVA 0.0316


Top enriched genes
Top 20 genes
GeneID Gene Rank
Dld -8061
Sucla2 -7990
Fahd1 -7792
Me3 -7330
Suclg1 -6601
Idh3a -6469
Sdhb -6142
Idh3g -6108
Fh1 -4684
Mdh2 -4201
Aco2 -3965
Idh3b -3769
Sdhd -2734
Me2 -2245
Sdhc -1459
Cs -690
Nnt 459
Sdha 1613
Dlst 2215
Ogdh 2896

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dld -8061
Sucla2 -7990
Fahd1 -7792
Me3 -7330
Suclg1 -6601
Idh3a -6469
Sdhb -6142
Idh3g -6108
Fh1 -4684
Mdh2 -4201
Aco2 -3965
Idh3b -3769
Sdhd -2734
Me2 -2245
Sdhc -1459
Cs -690
Nnt 459
Sdha 1613
Dlst 2215
Ogdh 2896
Suclg2 6472
Idh2 9146


NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS
set NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS
setSize 15
pANOVA 0.015
s.dist 0.363
p.adjustANOVA 0.095


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc6a7 9087
Slc6a6 8803
Slc6a11 8631
Slc6a9 8020
Slc6a1 7338
Slc22a2 6594
Slc18a2 5635
Slc6a2 5068
Slc6a20a 3309
Slc6a19 2352
Slc6a13 1499
Slc6a3 1455
Slc6a12 -2738
Slc6a15 -3632
Slc6a5 -6082

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc6a7 9087
Slc6a6 8803
Slc6a11 8631
Slc6a9 8020
Slc6a1 7338
Slc22a2 6594
Slc18a2 5635
Slc6a2 5068
Slc6a20a 3309
Slc6a19 2352
Slc6a13 1499
Slc6a3 1455
Slc6a12 -2738
Slc6a15 -3632
Slc6a5 -6082


RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
set RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize 125
pANOVA 2.78e-12
s.dist -0.362
p.adjustANOVA 1.09e-09


Top enriched genes
Top 20 genes
GeneID Gene Rank
Cycs -8030
Dmac2l -7964
Atp5c1 -7957
Ndufaf4 -7868
Atp5pb -7748
mt-Co2 -7682
Ndufv2 -7656
Ndufaf1 -7469
Cox16 -7133
Ndufaf5 -7082
Uqcrc2 -6944
Ndufa10 -6620
Ndufs8 -6346
Etfa -6345
Ndufb5 -6247
Uqcrfs1 -6242
Coq10b -6237
Atp5o -6217
Sco1 -6175
Sdhb -6142

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8030
Dmac2l -7964
Atp5c1 -7957
Ndufaf4 -7868
Atp5pb -7748
mt-Co2 -7682
Ndufv2 -7656
Ndufaf1 -7469
Cox16 -7133
Ndufaf5 -7082
Uqcrc2 -6944
Ndufa10 -6620
Ndufs8 -6346
Etfa -6345
Ndufb5 -6247
Uqcrfs1 -6242
Coq10b -6237
Atp5o -6217
Sco1 -6175
Sdhb -6142
Atp5l -6123
Ndufs4 -6002
Ndufab1 -5907
Ndufaf2 -5871
Cox5a -5848
Ndufc2 -5708
mt-Nd6 -5663
Ndufs1 -5656
Ndufaf6 -5594
Cox7b -5578
Atp5h -5528
Ndufb6 -5473
Atp5b -5445
mt-Co3 -5281
Ndufb10 -5238
Ndufs3 -5124
Etfdh -4906
mt-Nd1 -4844
mt-Nd2 -4781
Ndufb11 -4773
Ucp3 -4767
mt-Atp6 -4709
Ndufa11 -4644
Cyc1 -4449
Ndufs5 -4413
Cox6b1 -4382
Ndufa4 -4298
Cox14 -4210
Nubpl -4196
Ndufa9 -4089
Coq10a -4069
mt-Nd4 -3966
Uqcrh -3955
Atp5g3 -3713
Ndufb2 -3710
Uqcrb -3701
Ndufb8 -3628
mt-Cytb -3524
Atp5a1 -3491
Ndufb3 -3471
Ndufb9 -3216
Ndufc1 -3162
Surf1 -3105
Ndufa5 -2848
Sdhd -2734
Acad9 -2499
Tmem126b -2435
Cox7a2l -2393
Cox6a1 -2388
mt-Co1 -2373
Taco1 -2353
Atp5j2 -2337
Lrpprc -2267
Uqcrc1 -2164
Cox4i1 -2090
Cox7c -2027
Ndufv1 -1902
mt-Nd5 -1899
Ndufb4 -1843
Atp5d -1655
Sdhc -1459
Atp5j -1397
Cox20 -1000
Cox6c -980
Ndufa1 -976
Ndufa8 -890
Cox11 -886
Trap1 -877
Ecsit -799
Ndufa6 -730
Ndufs2 -313
Uqcrq -45
Sco2 -39
Timmdc1 127
Ndufa2 192
Ndufb1 288
Atp5g1 399
Ndufb7 526
Ndufv3 528
Ndufs7 540
Ndufa7 677
Atp5g2 802
Ndufa12 818
Etfb 929
Ndufs6 970
Slc25a14 1016
Uqcr10 1018
Uqcr11 1032
Atp5e 1074
Cox19 1233
Cox5b 1282
Sdha 1613
Ndufaf3 1638
Cox18 1693
Slc25a27 1706
Atp5k 2319
Ndufa3 2456
Pm20d1 2520
Cox8a 2988
Ndufa13 3399
Ndufaf7 4178
mt-Nd3 4619
Tmem186 6798
mt-Atp8 8363
Ucp2 8831


MITOCHONDRIAL PROTEIN IMPORT
set MITOCHONDRIAL PROTEIN IMPORT
setSize 63
pANOVA 7.91e-07
s.dist -0.36
p.adjustANOVA 6.22e-05


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mtx2 -7802
Timm8a1 -7663
Cmc4 -7637
Timm21 -7063
Tomm70a -7010
Pmpcb -6784
Timm23 -6714
Slc25a4 -6587
Chchd5 -6362
Cmc2 -6358
Idh3g -6108
Hspd1 -5888
Timm44 -5759
Chchd7 -5501
Atp5b -5445
Chchd3 -5372
Chchd2 -5114
Slc25a13 -5110
Grpel2 -5019
Tomm22 -4989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mtx2 -7802
Timm8a1 -7663
Cmc4 -7637
Timm21 -7063
Tomm70a -7010
Pmpcb -6784
Timm23 -6714
Slc25a4 -6587
Chchd5 -6362
Cmc2 -6358
Idh3g -6108
Hspd1 -5888
Timm44 -5759
Chchd7 -5501
Atp5b -5445
Chchd3 -5372
Chchd2 -5114
Slc25a13 -5110
Grpel2 -5019
Tomm22 -4989
Timm9 -4940
Cyc1 -4449
Fxn -4395
Vdac1 -4138
Aco2 -3965
Tomm20 -3688
Ndufb8 -3628
Atp5a1 -3491
Timm50 -3353
Taz -2876
Hspa9 -2569
Timm10b -2325
Chchd4 -2300
Dnajc19 -2240
Timm8b -2173
Ldhd -2170
Pitrm1 -1890
Pmpca -1850
Chchd10 -1807
Tomm5 -1782
Timm17a -1445
Tomm7 -722
Cs -690
Timm10 -415
Hscb -402
Coa6 -390
Slc25a12 1
Grpel1 11
Samm50 145
Mtx1 281
Atp5g1 399
Gfer 415
Pam16 913
Coa4 924
Timm17b 1088
Cox17 1172
Cox19 1233
Timm13 1374
Timm22 2592
Tomm6 2824
Bcs1l 3579
Coq2 3977
Tomm40 5502


ORGANIC CATION ANION ZWITTERION TRANSPORT
set ORGANIC CATION ANION ZWITTERION TRANSPORT
setSize 12
pANOVA 0.0321
s.dist 0.357
p.adjustANOVA 0.151


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc22a18 8862
Runx1 7136
Slc22a12 7135
Slc22a3 6812
Slc22a2 6594
Rsc1a1 4898
Slc22a6 3772
Slc22a4 2865
Slc22a7 2697
Slc22a15 -10
Slc22a8 -3396
Slc22a5 -3629

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc22a18 8862
Runx1 7136
Slc22a12 7135
Slc22a3 6812
Slc22a2 6594
Rsc1a1 4898
Slc22a6 3772
Slc22a4 2865
Slc22a7 2697
Slc22a15 -10
Slc22a8 -3396
Slc22a5 -3629


CHOLESTEROL BIOSYNTHESIS
set CHOLESTEROL BIOSYNTHESIS
setSize 24
pANOVA 0.00249
s.dist -0.357
p.adjustANOVA 0.0267


Top enriched genes
Top 20 genes
GeneID Gene Rank
Idi1 -8021
Ggps1 -7745
Msmo1 -7743
Hsd17b7 -7407
Nsdhl -7282
Cyp51 -7218
Plpp6 -6288
Hmgcs1 -5835
Fdft1 -5533
Sqle -3979
Ebp -3121
Dhcr7 -3052
Mvd -3002
Fdps -2858
Lbr -2857
Acat3 -1841
Hmgcr -873
Arv1 649
Pmvk 1853
Sc5d 2343

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Idi1 -8021
Ggps1 -7745
Msmo1 -7743
Hsd17b7 -7407
Nsdhl -7282
Cyp51 -7218
Plpp6 -6288
Hmgcs1 -5835
Fdft1 -5533
Sqle -3979
Ebp -3121
Dhcr7 -3052
Mvd -3002
Fdps -2858
Lbr -2857
Acat3 -1841
Hmgcr -873
Arv1 649
Pmvk 1853
Sc5d 2343
Tm7sf2 3673
Mvk 4053
Lss 4551
Dhcr24 6311


TNFR1 INDUCED PROAPOPTOTIC SIGNALING
set TNFR1 INDUCED PROAPOPTOTIC SIGNALING
setSize 12
pANOVA 0.0329
s.dist 0.356
p.adjustANOVA 0.153


Top enriched genes
Top 20 genes
GeneID Gene Rank
Otud7b 8179
Ripk1 7899
Usp2 7737
Cyld 5835
Usp21 5547
Fadd 4422
Tnfaip3 3428
Tnfrsf1a 3386
Usp4 2904
Traf2 1889
Casp8 -3464
Tradd -4197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Otud7b 8179
Ripk1 7899
Usp2 7737
Cyld 5835
Usp21 5547
Fadd 4422
Tnfaip3 3428
Tnfrsf1a 3386
Usp4 2904
Traf2 1889
Casp8 -3464
Tradd -4197


SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER
set SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER
setSize 15
pANOVA 0.0172
s.dist 0.355
p.adjustANOVA 0.103


Top enriched genes
Top 20 genes
GeneID Gene Rank
Mib2 9213
Jag2 9164
Jag1 9048
Notch1 9000
Neurl1b 7249
Uba52 5453
Adam17 5069
Dll1 3325
Mib1 1763
Ubc 799
Adam10 27
Neurl1a -826
Dll4 -1180
Rps27a -1713
Ubb -2021

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mib2 9213
Jag2 9164
Jag1 9048
Notch1 9000
Neurl1b 7249
Uba52 5453
Adam17 5069
Dll1 3325
Mib1 1763
Ubc 799
Adam10 27
Neurl1a -826
Dll4 -1180
Rps27a -1713
Ubb -2021


AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE
set AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE
setSize 27
pANOVA 0.00151
s.dist 0.353
p.adjustANOVA 0.018


Top enriched genes
Top 20 genes
GeneID Gene Rank
Slc7a2 8959
Slc6a6 8803
Slc36a2 8670
Slc7a5 8537
Slc7a7 8461
Slc7a3 7880
Slc43a2 6726
Slc1a5 6650
Slc38a1 6595
Slc3a2 6449
Slc7a11 6119
Slc7a8 5853
Slc1a4 5832
Slc7a1 5815
Slc25a29 4353
Slc38a2 3377
Slc36a1 3370
Slc6a20a 3309
Slc6a19 2352
Slc7a10 -465

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc7a2 8959
Slc6a6 8803
Slc36a2 8670
Slc7a5 8537
Slc7a7 8461
Slc7a3 7880
Slc43a2 6726
Slc1a5 6650
Slc38a1 6595
Slc3a2 6449
Slc7a11 6119
Slc7a8 5853
Slc1a4 5832
Slc7a1 5815
Slc25a29 4353
Slc38a2 3377
Slc36a1 3370
Slc6a20a 3309
Slc6a19 2352
Slc7a10 -465
Slc38a3 -733
Slc7a6 -884
Slc36a4 -957
Slc6a12 -2738
Slc6a15 -3632
Slc16a10 -5302
Slc38a5 -6149


PENTOSE PHOSPHATE PATHWAY
set PENTOSE PHOSPHATE PATHWAY
setSize 13
pANOVA 0.0285
s.dist -0.351
p.adjustANOVA 0.143


Top enriched genes
Top 20 genes
GeneID Gene Rank
Rpe -7665
Rbks -7343
Prps2 -6923
Pgm2 -5826
Shpk -5733
Taldo1 -4835
Dera -4721
G6pdx -2578
Rpia -681
Tkt 1010
Prps1 1285
Pgls 4037
Pgd 7424

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpe -7665
Rbks -7343
Prps2 -6923
Pgm2 -5826
Shpk -5733
Taldo1 -4835
Dera -4721
G6pdx -2578
Rpia -681
Tkt 1010
Prps1 1285
Pgls 4037
Pgd 7424


PKA ACTIVATION IN GLUCAGON SIGNALLING
set PKA ACTIVATION IN GLUCAGON SIGNALLING
setSize 16
pANOVA 0.0151
s.dist 0.351
p.adjustANOVA 0.095


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adcy6 8823
Adcy5 8013
Adcy4 7918
Adcy2 7684
Prkaca 5537
Adcy3 4779
Adcy7 4460
Gnas 4023
Adcy9 3939
Adcy8 3833
Prkar2a 2315
Prkar2b 739
Prkar1b 587
Adcy1 -374
Prkacb -1784
Prkar1a -3107

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8823
Adcy5 8013
Adcy4 7918
Adcy2 7684
Prkaca 5537
Adcy3 4779
Adcy7 4460
Gnas 4023
Adcy9 3939
Adcy8 3833
Prkar2a 2315
Prkar2b 739
Prkar1b 587
Adcy1 -374
Prkacb -1784
Prkar1a -3107


ADENYLATE CYCLASE INHIBITORY PATHWAY
set ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize 13
pANOVA 0.0291
s.dist 0.349
p.adjustANOVA 0.144


Top enriched genes
Top 20 genes
GeneID Gene Rank
Adcy6 8823
Gnai2 8538
Adcy5 8013
Adcy4 7918
Adcy2 7684
Adcy3 4779
Adcy7 4460
Adcy9 3939
Adcy8 3833
Adcy1 -374
Gnal -1543
Gnai3 -4519
Gnai1 -5066

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8823
Gnai2 8538
Adcy5 8013
Adcy4 7918
Adcy2 7684
Adcy3 4779
Adcy7 4460
Adcy9 3939
Adcy8 3833
Adcy1 -374
Gnal -1543
Gnai3 -4519
Gnai1 -5066


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report