date generated: 2023-08-30

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
hyp amy hip pag ni
0610009B22Rik -0.3304181 0.2684894 -3.3814425 0.0259293 -2.3583781
0610009E02Rik 0.7596333 -0.7521235 -0.3557659 0.7519591 -0.4921631
0610009L18Rik -1.2521412 -1.1838923 -0.8507498 -1.0644467 -1.5061599
0610010K14Rik 0.4193627 -0.0433030 1.2510787 0.4476085 -0.7608005
0610012G03Rik 1.4462155 -0.1930476 3.9729326 -0.1633199 -0.6314820
0610030E20Rik -0.2426628 1.0496464 0.1581737 -0.6249661 1.2199694

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 15915
duplicated_genes_present 0
num_profile_genes_in_sets 8073
num_profile_genes_not_in_sets 7842

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 448
num_genesets_included 1156
Genes by sector
hyp amy hip pag ni Count
-1 -1 -1 -1 -1 1567
1 -1 -1 -1 -1 267
-1 1 -1 -1 -1 444
1 1 -1 -1 -1 216
1 1 0 -1 -1 1
-1 -1 1 -1 -1 307
1 -1 1 -1 -1 292
-1 1 1 -1 -1 165
1 1 1 -1 -1 377
-1 -1 -1 1 -1 1746
1 -1 -1 1 -1 485
-1 1 -1 1 -1 332
1 1 -1 1 -1 358
-1 -1 1 1 -1 162
1 -1 1 1 -1 452
-1 1 1 1 -1 113
1 1 1 1 -1 527
1 1 -1 1 0 1
-1 -1 -1 -1 1 639
1 -1 -1 -1 1 133
-1 1 -1 -1 1 388
0 1 -1 -1 1 1
1 1 -1 -1 1 225
-1 -1 1 -1 1 626
1 -1 1 -1 1 410
-1 1 1 -1 1 628
1 1 1 -1 1 1368
1 1 1 0 1 1
-1 -1 -1 1 1 281
1 -1 -1 1 1 198
-1 1 -1 1 1 152
1 1 -1 1 1 217
-1 -1 1 1 1 243
1 -1 1 1 1 532
1 0 1 1 1 1
-1 1 1 1 1 287
1 1 1 1 1 1773
Number of significant gene sets (FDR<0.05)= 392

Gene sets by sector


Gene sets by sector
s.hyp s.amy s.hip s.pag s.ni Count
-1 -1 -1 -1 -1 8
1 -1 -1 -1 -1 6
-1 1 -1 -1 -1 2
1 1 -1 -1 -1 25
-1 -1 1 -1 -1 2
1 -1 1 -1 -1 3
1 1 1 -1 -1 6
-1 -1 -1 1 -1 22
1 -1 -1 1 -1 33
-1 1 -1 1 -1 1
1 1 -1 1 -1 84
-1 -1 1 1 -1 8
1 -1 1 1 -1 17
-1 1 1 1 -1 5
1 1 1 1 -1 28
-1 -1 -1 -1 1 7
-1 1 -1 -1 1 1
1 1 -1 -1 1 1
-1 -1 1 -1 1 10
-1 1 1 -1 1 19
1 1 1 -1 1 17
-1 -1 -1 1 1 7
-1 1 -1 1 1 4
1 1 -1 1 1 3
-1 -1 1 1 1 27
1 -1 1 1 1 10
-1 1 1 1 1 15
1 1 1 1 1 21

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pMANOVA p.adjustMANOVA s.dist s.hyp s.amy s.hip s.pag s.ni p.hyp p.amy p.hip p.pag p.ni
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.78e-10 3.16e-09 1.010 0.5820 0.1560 0.1540 0.6950 -0.38300 1.11e-05 2.39e-01 0.244000 1.53e-07 3.85e-03
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 1.73e-05 1.28e-04 0.973 0.5930 0.3170 0.4490 0.5230 -0.13700 2.12e-04 4.81e-02 0.005090 1.09e-03 3.92e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 1.10e-06 1.04e-05 0.941 0.6300 0.3160 0.5030 0.3590 -0.08450 6.79e-06 2.39e-02 0.000330 1.04e-02 5.47e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.92e-04 1.10e-03 0.864 -0.0884 0.2080 0.4570 0.1620 0.67800 6.28e-01 2.54e-01 0.012400 3.76e-01 2.03e-04
CROSSLINKING OF COLLAGEN FIBRILS 13 1.78e-02 5.16e-02 0.832 0.3350 0.4010 0.5670 0.0344 0.31100 3.65e-02 1.22e-02 0.000399 8.30e-01 5.21e-02
MET ACTIVATES RAP1 AND RAC1 10 6.45e-02 1.39e-01 0.822 -0.3640 -0.5400 -0.3610 0.1320 -0.32200 4.65e-02 3.09e-03 0.048100 4.68e-01 7.81e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 5.16e-07 5.21e-06 0.798 0.5140 0.2580 0.3150 0.4230 -0.16700 2.01e-05 3.19e-02 0.008920 4.49e-04 1.65e-01
CD28 DEPENDENT VAV1 PATHWAY 11 2.60e-02 6.90e-02 0.790 -0.1270 -0.3170 -0.4380 0.3940 -0.40000 4.67e-01 6.87e-02 0.011800 2.36e-02 2.18e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.37e-02 4.19e-02 0.782 0.3880 0.4370 0.4570 -0.1600 0.19000 1.54e-02 6.43e-03 0.004330 3.18e-01 2.37e-01
ACTIVATION OF RAC1 13 2.13e-02 5.97e-02 0.759 -0.2230 -0.5010 -0.3740 0.2290 -0.28800 1.65e-01 1.76e-03 0.019500 1.53e-01 7.20e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.65e-02 4.88e-02 0.757 -0.3770 -0.4370 -0.3850 0.2700 -0.13800 3.05e-02 1.21e-02 0.026900 1.21e-01 4.28e-01
GAP JUNCTION ASSEMBLY 21 2.17e-05 1.55e-04 0.745 0.4380 0.2260 0.3190 0.4390 -0.13300 5.06e-04 7.29e-02 0.011300 5.03e-04 2.91e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.07e-05 8.44e-05 0.736 -0.0487 -0.2220 -0.4020 0.3230 -0.47400 6.50e-01 3.87e-02 0.000179 2.62e-03 9.97e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.19e-08 2.83e-07 0.733 0.3870 0.1650 0.0234 0.4610 -0.38400 6.47e-04 1.46e-01 0.836000 4.79e-05 6.98e-04
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.25e-03 9.24e-03 0.720 0.1520 0.3670 0.0551 0.5900 0.09830 3.61e-01 2.79e-02 0.741000 3.98e-04 5.55e-01
CGMP EFFECTS 15 3.71e-03 1.42e-02 0.717 -0.5590 -0.3010 -0.2270 -0.2410 0.01800 1.76e-04 4.32e-02 0.128000 1.06e-01 9.04e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 1.86e-02 5.31e-02 0.717 -0.5540 -0.3040 -0.2000 -0.2660 0.05770 1.46e-03 8.04e-02 0.252000 1.27e-01 7.40e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.95e-02 5.53e-02 0.715 -0.1100 -0.1520 -0.5270 0.0254 -0.44500 5.11e-01 3.62e-01 0.001590 8.79e-01 7.60e-03
PHASE 2 PLATEAU PHASE 10 1.07e-01 1.98e-01 0.706 0.1580 0.1610 0.3950 -0.1850 0.50600 3.87e-01 3.78e-01 0.030500 3.12e-01 5.55e-03
PROCESSING AND ACTIVATION OF SUMO 10 3.16e-02 7.97e-02 0.704 0.0187 -0.2960 -0.4770 0.2290 -0.35700 9.18e-01 1.05e-01 0.009050 2.09e-01 5.04e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.17e-02 3.68e-02 0.703 0.0315 -0.2520 -0.0583 0.5450 -0.35800 8.56e-01 1.48e-01 0.738000 1.74e-03 3.96e-02
RHOBTB3 ATPASE CYCLE 10 4.28e-02 1.01e-01 0.698 0.0103 -0.1460 -0.2390 0.5340 -0.35300 9.55e-01 4.24e-01 0.190000 3.48e-03 5.35e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 7.55e-02 1.55e-01 0.690 -0.0983 -0.2420 -0.3830 0.4120 -0.30400 5.90e-01 1.86e-01 0.036100 2.42e-02 9.58e-02
MATURATION OF NUCLEOPROTEIN 10 1.54e-01 2.61e-01 0.685 -0.3390 -0.1650 -0.3400 -0.3400 -0.31000 6.37e-02 3.67e-01 0.062300 6.27e-02 8.97e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.70e-04 9.80e-04 0.684 -0.1300 0.0211 0.2720 -0.2470 0.56100 3.52e-01 8.80e-01 0.052500 7.73e-02 6.18e-05
ACTIVATION OF SMO 16 5.54e-02 1.24e-01 0.675 0.2140 0.3000 0.4250 0.0957 0.36100 1.38e-01 3.79e-02 0.003210 5.08e-01 1.25e-02
IRE1ALPHA ACTIVATES CHAPERONES 49 6.90e-07 6.70e-06 0.674 0.4160 0.2180 0.2620 0.3540 0.20200 4.72e-07 8.43e-03 0.001540 1.83e-05 1.44e-02
INTERACTION BETWEEN L1 AND ANKYRINS 27 8.47e-08 9.79e-07 0.674 -0.2530 0.0476 0.2230 -0.2730 0.51300 2.28e-02 6.69e-01 0.044800 1.40e-02 3.90e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 4.91e-03 1.77e-02 0.672 0.0202 0.2150 0.4210 0.3850 0.28300 9.08e-01 2.16e-01 0.015700 2.71e-02 1.04e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.77e-03 2.01e-02 0.669 0.3090 0.1790 0.2880 0.2350 0.42600 1.66e-02 1.66e-01 0.025800 6.94e-02 9.75e-04
COHESIN LOADING ONTO CHROMATIN 10 9.97e-03 3.23e-02 0.667 -0.3420 0.1020 -0.5240 -0.1820 -0.09720 6.10e-02 5.77e-01 0.004130 3.19e-01 5.95e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 1.35e-01 2.36e-01 0.666 0.3270 0.4400 0.2760 -0.0868 0.24300 4.97e-02 8.29e-03 0.097500 6.03e-01 1.44e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.87e-05 1.36e-04 0.661 0.1690 0.1160 -0.2080 0.5170 -0.28900 1.61e-01 3.35e-01 0.083800 1.75e-05 1.65e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 5.15e-04 2.61e-03 0.658 -0.5130 -0.2710 -0.1960 -0.2250 0.08420 7.11e-05 3.56e-02 0.129000 8.19e-02 5.14e-01
AGGREPHAGY 34 3.97e-05 2.65e-04 0.656 0.4150 0.3300 0.2220 0.3140 0.02650 2.76e-05 8.61e-04 0.025100 1.52e-03 7.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 1.08e-02 3.47e-02 0.651 -0.0758 -0.2280 -0.3140 0.3110 -0.41400 5.67e-01 8.56e-02 0.017900 1.88e-02 1.79e-03
RETROGRADE NEUROTROPHIN SIGNALLING 12 1.12e-02 3.57e-02 0.650 0.2320 -0.0734 0.2630 0.5410 0.03440 1.64e-01 6.60e-01 0.115000 1.17e-03 8.37e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 1.69e-02 4.99e-02 0.649 -0.0646 -0.1390 -0.5130 0.0676 -0.36100 6.87e-01 3.85e-01 0.001350 6.73e-01 2.43e-02
INTERFERON ALPHA BETA SIGNALING 51 1.09e-08 1.47e-07 0.646 -0.2140 -0.3050 -0.1980 -0.3900 -0.29600 8.17e-03 1.69e-04 0.014500 1.50e-06 2.58e-04
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 2.46e-02 6.67e-02 0.638 0.4730 0.0656 0.1440 0.3960 0.02870 3.14e-03 6.82e-01 0.367000 1.34e-02 8.58e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 7.76e-04 3.68e-03 0.637 -0.2240 -0.0124 -0.3420 0.3790 -0.30700 8.36e-02 9.23e-01 0.008020 3.33e-03 1.76e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 13 4.45e-04 2.34e-03 0.636 0.0940 -0.3760 0.0607 0.0888 -0.49200 5.57e-01 1.89e-02 0.705000 5.79e-01 2.11e-03
EUKARYOTIC TRANSLATION ELONGATION 87 1.68e-38 6.46e-36 0.635 0.3030 0.4360 -0.1310 -0.1910 -0.26100 1.08e-06 2.05e-12 0.034800 2.07e-03 2.57e-05
GLYCOGEN STORAGE DISEASES 12 5.37e-02 1.21e-01 0.634 0.4120 0.1790 0.1020 0.4360 -0.00353 1.34e-02 2.83e-01 0.542000 8.90e-03 9.83e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 2.30e-02 6.32e-02 0.633 -0.1010 -0.0460 0.2940 -0.3260 0.44200 5.63e-01 7.92e-01 0.091400 6.10e-02 1.11e-02
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 1.44e-04 8.55e-04 0.629 0.3420 0.0541 0.3600 0.3590 -0.13300 8.12e-03 6.75e-01 0.005350 5.41e-03 3.02e-01
RHO GTPASES ACTIVATE IQGAPS 22 1.03e-04 6.39e-04 0.626 0.2700 0.1220 0.2980 0.4440 -0.13300 2.86e-02 3.23e-01 0.015400 3.12e-04 2.79e-01
KERATAN SULFATE BIOSYNTHESIS 23 4.53e-04 2.36e-03 0.625 0.3250 0.0249 0.2280 0.4810 -0.04760 7.03e-03 8.36e-01 0.058800 6.61e-05 6.93e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 3.31e-02 8.31e-02 0.622 -0.0415 -0.0456 -0.4520 0.2220 -0.36000 8.04e-01 7.85e-01 0.006660 1.83e-01 3.08e-02
CYTOSOLIC TRNA AMINOACYLATION 24 6.09e-05 3.98e-04 0.620 0.3540 0.2960 -0.0172 0.3860 -0.15000 2.72e-03 1.20e-02 0.884000 1.07e-03 2.04e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.hyp s.amy s.hip s.pag s.ni p.hyp p.amy p.hip p.pag p.ni
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.78e-10 3.16e-09 1.0100 0.582000 0.156000 0.154000 0.695000 -0.383000 1.11e-05 2.39e-01 2.44e-01 1.53e-07 3.85e-03
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 1.73e-05 1.28e-04 0.9730 0.593000 0.317000 0.449000 0.523000 -0.137000 2.12e-04 4.81e-02 5.09e-03 1.09e-03 3.92e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 1.10e-06 1.04e-05 0.9410 0.630000 0.316000 0.503000 0.359000 -0.084500 6.79e-06 2.39e-02 3.30e-04 1.04e-02 5.47e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.92e-04 1.10e-03 0.8640 -0.088400 0.208000 0.457000 0.162000 0.678000 6.28e-01 2.54e-01 1.24e-02 3.76e-01 2.03e-04
CROSSLINKING OF COLLAGEN FIBRILS 13 1.78e-02 5.16e-02 0.8320 0.335000 0.401000 0.567000 0.034400 0.311000 3.65e-02 1.22e-02 3.99e-04 8.30e-01 5.21e-02
MET ACTIVATES RAP1 AND RAC1 10 6.45e-02 1.39e-01 0.8220 -0.364000 -0.540000 -0.361000 0.132000 -0.322000 4.65e-02 3.09e-03 4.81e-02 4.68e-01 7.81e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 5.16e-07 5.21e-06 0.7980 0.514000 0.258000 0.315000 0.423000 -0.167000 2.01e-05 3.19e-02 8.92e-03 4.49e-04 1.65e-01
CD28 DEPENDENT VAV1 PATHWAY 11 2.60e-02 6.90e-02 0.7900 -0.127000 -0.317000 -0.438000 0.394000 -0.400000 4.67e-01 6.87e-02 1.18e-02 2.36e-02 2.18e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.37e-02 4.19e-02 0.7820 0.388000 0.437000 0.457000 -0.160000 0.190000 1.54e-02 6.43e-03 4.33e-03 3.18e-01 2.37e-01
ACTIVATION OF RAC1 13 2.13e-02 5.97e-02 0.7590 -0.223000 -0.501000 -0.374000 0.229000 -0.288000 1.65e-01 1.76e-03 1.95e-02 1.53e-01 7.20e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.65e-02 4.88e-02 0.7570 -0.377000 -0.437000 -0.385000 0.270000 -0.138000 3.05e-02 1.21e-02 2.69e-02 1.21e-01 4.28e-01
GAP JUNCTION ASSEMBLY 21 2.17e-05 1.55e-04 0.7450 0.438000 0.226000 0.319000 0.439000 -0.133000 5.06e-04 7.29e-02 1.13e-02 5.03e-04 2.91e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.07e-05 8.44e-05 0.7360 -0.048700 -0.222000 -0.402000 0.323000 -0.474000 6.50e-01 3.87e-02 1.79e-04 2.62e-03 9.97e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.19e-08 2.83e-07 0.7330 0.387000 0.165000 0.023400 0.461000 -0.384000 6.47e-04 1.46e-01 8.36e-01 4.79e-05 6.98e-04
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.25e-03 9.24e-03 0.7200 0.152000 0.367000 0.055100 0.590000 0.098300 3.61e-01 2.79e-02 7.41e-01 3.98e-04 5.55e-01
CGMP EFFECTS 15 3.71e-03 1.42e-02 0.7170 -0.559000 -0.301000 -0.227000 -0.241000 0.018000 1.76e-04 4.32e-02 1.28e-01 1.06e-01 9.04e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 1.86e-02 5.31e-02 0.7170 -0.554000 -0.304000 -0.200000 -0.266000 0.057700 1.46e-03 8.04e-02 2.52e-01 1.27e-01 7.40e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.95e-02 5.53e-02 0.7150 -0.110000 -0.152000 -0.527000 0.025400 -0.445000 5.11e-01 3.62e-01 1.59e-03 8.79e-01 7.60e-03
PHASE 2 PLATEAU PHASE 10 1.07e-01 1.98e-01 0.7060 0.158000 0.161000 0.395000 -0.185000 0.506000 3.87e-01 3.78e-01 3.05e-02 3.12e-01 5.55e-03
PROCESSING AND ACTIVATION OF SUMO 10 3.16e-02 7.97e-02 0.7040 0.018700 -0.296000 -0.477000 0.229000 -0.357000 9.18e-01 1.05e-01 9.05e-03 2.09e-01 5.04e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.17e-02 3.68e-02 0.7030 0.031500 -0.252000 -0.058300 0.545000 -0.358000 8.56e-01 1.48e-01 7.38e-01 1.74e-03 3.96e-02
RHOBTB3 ATPASE CYCLE 10 4.28e-02 1.01e-01 0.6980 0.010300 -0.146000 -0.239000 0.534000 -0.353000 9.55e-01 4.24e-01 1.90e-01 3.48e-03 5.35e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 7.55e-02 1.55e-01 0.6900 -0.098300 -0.242000 -0.383000 0.412000 -0.304000 5.90e-01 1.86e-01 3.61e-02 2.42e-02 9.58e-02
MATURATION OF NUCLEOPROTEIN 10 1.54e-01 2.61e-01 0.6850 -0.339000 -0.165000 -0.340000 -0.340000 -0.310000 6.37e-02 3.67e-01 6.23e-02 6.27e-02 8.97e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.70e-04 9.80e-04 0.6840 -0.130000 0.021100 0.272000 -0.247000 0.561000 3.52e-01 8.80e-01 5.25e-02 7.73e-02 6.18e-05
ACTIVATION OF SMO 16 5.54e-02 1.24e-01 0.6750 0.214000 0.300000 0.425000 0.095700 0.361000 1.38e-01 3.79e-02 3.21e-03 5.08e-01 1.25e-02
IRE1ALPHA ACTIVATES CHAPERONES 49 6.90e-07 6.70e-06 0.6740 0.416000 0.218000 0.262000 0.354000 0.202000 4.72e-07 8.43e-03 1.54e-03 1.83e-05 1.44e-02
INTERACTION BETWEEN L1 AND ANKYRINS 27 8.47e-08 9.79e-07 0.6740 -0.253000 0.047600 0.223000 -0.273000 0.513000 2.28e-02 6.69e-01 4.48e-02 1.40e-02 3.90e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 4.91e-03 1.77e-02 0.6720 0.020200 0.215000 0.421000 0.385000 0.283000 9.08e-01 2.16e-01 1.57e-02 2.71e-02 1.04e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.77e-03 2.01e-02 0.6690 0.309000 0.179000 0.288000 0.235000 0.426000 1.66e-02 1.66e-01 2.58e-02 6.94e-02 9.75e-04
COHESIN LOADING ONTO CHROMATIN 10 9.97e-03 3.23e-02 0.6670 -0.342000 0.102000 -0.524000 -0.182000 -0.097200 6.10e-02 5.77e-01 4.13e-03 3.19e-01 5.95e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 1.35e-01 2.36e-01 0.6660 0.327000 0.440000 0.276000 -0.086800 0.243000 4.97e-02 8.29e-03 9.75e-02 6.03e-01 1.44e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.87e-05 1.36e-04 0.6610 0.169000 0.116000 -0.208000 0.517000 -0.289000 1.61e-01 3.35e-01 8.38e-02 1.75e-05 1.65e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 5.15e-04 2.61e-03 0.6580 -0.513000 -0.271000 -0.196000 -0.225000 0.084200 7.11e-05 3.56e-02 1.29e-01 8.19e-02 5.14e-01
AGGREPHAGY 34 3.97e-05 2.65e-04 0.6560 0.415000 0.330000 0.222000 0.314000 0.026500 2.76e-05 8.61e-04 2.51e-02 1.52e-03 7.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 1.08e-02 3.47e-02 0.6510 -0.075800 -0.228000 -0.314000 0.311000 -0.414000 5.67e-01 8.56e-02 1.79e-02 1.88e-02 1.79e-03
RETROGRADE NEUROTROPHIN SIGNALLING 12 1.12e-02 3.57e-02 0.6500 0.232000 -0.073400 0.263000 0.541000 0.034400 1.64e-01 6.60e-01 1.15e-01 1.17e-03 8.37e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 1.69e-02 4.99e-02 0.6490 -0.064600 -0.139000 -0.513000 0.067600 -0.361000 6.87e-01 3.85e-01 1.35e-03 6.73e-01 2.43e-02
INTERFERON ALPHA BETA SIGNALING 51 1.09e-08 1.47e-07 0.6460 -0.214000 -0.305000 -0.198000 -0.390000 -0.296000 8.17e-03 1.69e-04 1.45e-02 1.50e-06 2.58e-04
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 2.46e-02 6.67e-02 0.6380 0.473000 0.065600 0.144000 0.396000 0.028700 3.14e-03 6.82e-01 3.67e-01 1.34e-02 8.58e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 7.76e-04 3.68e-03 0.6370 -0.224000 -0.012400 -0.342000 0.379000 -0.307000 8.36e-02 9.23e-01 8.02e-03 3.33e-03 1.76e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 13 4.45e-04 2.34e-03 0.6360 0.094000 -0.376000 0.060700 0.088800 -0.492000 5.57e-01 1.89e-02 7.05e-01 5.79e-01 2.11e-03
EUKARYOTIC TRANSLATION ELONGATION 87 1.68e-38 6.46e-36 0.6350 0.303000 0.436000 -0.131000 -0.191000 -0.261000 1.08e-06 2.05e-12 3.48e-02 2.07e-03 2.57e-05
GLYCOGEN STORAGE DISEASES 12 5.37e-02 1.21e-01 0.6340 0.412000 0.179000 0.102000 0.436000 -0.003530 1.34e-02 2.83e-01 5.42e-01 8.90e-03 9.83e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 2.30e-02 6.32e-02 0.6330 -0.101000 -0.046000 0.294000 -0.326000 0.442000 5.63e-01 7.92e-01 9.14e-02 6.10e-02 1.11e-02
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 1.44e-04 8.55e-04 0.6290 0.342000 0.054100 0.360000 0.359000 -0.133000 8.12e-03 6.75e-01 5.35e-03 5.41e-03 3.02e-01
RHO GTPASES ACTIVATE IQGAPS 22 1.03e-04 6.39e-04 0.6260 0.270000 0.122000 0.298000 0.444000 -0.133000 2.86e-02 3.23e-01 1.54e-02 3.12e-04 2.79e-01
KERATAN SULFATE BIOSYNTHESIS 23 4.53e-04 2.36e-03 0.6250 0.325000 0.024900 0.228000 0.481000 -0.047600 7.03e-03 8.36e-01 5.88e-02 6.61e-05 6.93e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 3.31e-02 8.31e-02 0.6220 -0.041500 -0.045600 -0.452000 0.222000 -0.360000 8.04e-01 7.85e-01 6.66e-03 1.83e-01 3.08e-02
CYTOSOLIC TRNA AMINOACYLATION 24 6.09e-05 3.98e-04 0.6200 0.354000 0.296000 -0.017200 0.386000 -0.150000 2.72e-03 1.20e-02 8.84e-01 1.07e-03 2.04e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 2.55e-02 6.84e-02 0.6150 0.199000 0.428000 0.271000 -0.140000 0.249000 1.23e-01 9.28e-04 3.58e-02 2.78e-01 5.42e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.10e-03 8.68e-03 0.6140 0.261000 0.092200 0.338000 0.200000 0.382000 2.12e-02 4.16e-01 2.84e-03 7.79e-02 7.43e-04
INTERLEUKIN 37 SIGNALING 17 3.90e-02 9.37e-02 0.6080 0.107000 0.392000 0.270000 0.065200 0.357000 4.44e-01 5.14e-03 5.38e-02 6.42e-01 1.08e-02
E2F MEDIATED REGULATION OF DNA REPLICATION 19 7.64e-02 1.56e-01 0.6030 -0.182000 -0.307000 -0.324000 0.161000 -0.324000 1.71e-01 2.04e-02 1.45e-02 2.24e-01 1.44e-02
INITIAL TRIGGERING OF COMPLEMENT 10 1.37e-01 2.39e-01 0.6010 0.064200 0.469000 0.192000 -0.003900 0.317000 7.25e-01 1.02e-02 2.93e-01 9.83e-01 8.28e-02
PROLONGED ERK ACTIVATION EVENTS 12 8.24e-02 1.64e-01 0.5930 -0.252000 -0.400000 -0.187000 0.260000 -0.163000 1.31e-01 1.65e-02 2.63e-01 1.20e-01 3.28e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.46e-01 2.50e-01 0.5930 0.352000 0.375000 0.263000 0.113000 0.072000 2.82e-02 1.91e-02 1.00e-01 4.80e-01 6.53e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 5.16e-03 1.85e-02 0.5890 -0.251000 -0.053400 -0.251000 0.167000 -0.435000 5.17e-02 6.79e-01 5.17e-02 1.95e-01 7.56e-04
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.29e-02 6.32e-02 0.5880 -0.214000 -0.534000 -0.110000 0.029200 0.036800 2.20e-01 2.15e-03 5.27e-01 8.67e-01 8.33e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 4.76e-13 1.34e-11 0.5860 0.326000 0.129000 -0.207000 0.196000 -0.373000 1.30e-04 1.31e-01 1.51e-02 2.17e-02 1.20e-05
G BETA GAMMA SIGNALLING THROUGH CDC42 18 7.47e-02 1.54e-01 0.5860 -0.134000 -0.228000 -0.301000 0.225000 -0.363000 3.25e-01 9.41e-02 2.69e-02 9.84e-02 7.72e-03
INSULIN PROCESSING 24 9.69e-05 6.05e-04 0.5840 -0.213000 -0.313000 -0.302000 0.325000 -0.015200 7.03e-02 7.86e-03 1.05e-02 5.82e-03 8.98e-01
LGI ADAM INTERACTIONS 14 9.90e-03 3.22e-02 0.5830 -0.102000 0.185000 0.284000 0.011600 0.463000 5.10e-01 2.30e-01 6.56e-02 9.40e-01 2.69e-03
KERATAN SULFATE KERATIN METABOLISM 29 2.91e-04 1.62e-03 0.5820 0.321000 0.035900 0.206000 0.438000 -0.024100 2.74e-03 7.38e-01 5.48e-02 4.52e-05 8.22e-01
CITRIC ACID CYCLE TCA CYCLE 22 9.04e-04 4.20e-03 0.5820 0.169000 0.088400 -0.013500 0.499000 -0.229000 1.70e-01 4.73e-01 9.13e-01 5.03e-05 6.33e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.60e-02 8.95e-02 0.5810 0.029800 -0.042500 -0.022900 0.542000 -0.200000 8.58e-01 7.99e-01 8.91e-01 1.14e-03 2.30e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 8.86e-08 1.01e-06 0.5800 0.302000 0.167000 0.032700 0.446000 -0.131000 2.96e-04 4.59e-02 6.95e-01 9.18e-08 1.16e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 1.49e-01 2.54e-01 0.5780 0.009110 -0.168000 -0.224000 0.399000 -0.311000 9.58e-01 3.35e-01 1.98e-01 2.20e-02 7.43e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 65 2.19e-16 9.75e-15 0.5760 0.389000 0.142000 -0.053200 0.237000 -0.318000 5.76e-08 4.73e-02 4.59e-01 9.69e-04 9.05e-06
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 34 4.52e-04 2.36e-03 0.5760 0.383000 0.123000 0.322000 0.252000 0.054400 1.12e-04 2.14e-01 1.15e-03 1.11e-02 5.83e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 2.15e-03 8.90e-03 0.5730 0.087200 -0.004070 -0.236000 0.337000 -0.389000 4.89e-01 9.74e-01 6.15e-02 7.59e-03 2.02e-03
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.98e-02 9.44e-02 0.5710 -0.441000 -0.134000 -0.299000 0.156000 -0.006620 1.14e-02 4.42e-01 8.61e-02 3.70e-01 9.70e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 15 1.38e-01 2.40e-01 0.5710 0.299000 0.402000 0.202000 0.115000 0.142000 4.47e-02 7.00e-03 1.75e-01 4.42e-01 3.40e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 2.90e-02 7.53e-02 0.5670 -0.114000 0.072200 -0.199000 0.102000 -0.504000 5.12e-01 6.78e-01 2.54e-01 5.57e-01 3.83e-03
RECEPTOR MEDIATED MITOPHAGY 11 2.58e-02 6.88e-02 0.5670 -0.057900 0.023100 -0.038800 0.400000 -0.394000 7.39e-01 8.94e-01 8.24e-01 2.16e-02 2.35e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 60 2.44e-05 1.70e-04 0.5650 0.241000 0.356000 0.309000 -0.048700 0.192000 1.27e-03 1.81e-06 3.52e-05 5.14e-01 1.03e-02
METABOLISM OF POLYAMINES 57 1.36e-13 4.63e-12 0.5640 0.260000 0.071300 -0.227000 0.222000 -0.381000 7.03e-04 3.52e-01 3.00e-03 3.75e-03 6.58e-07
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 2.79e-33 4.61e-31 0.5630 0.231000 0.373000 -0.154000 -0.164000 -0.271000 1.07e-04 4.05e-10 9.97e-03 5.97e-03 5.47e-06
RAB GERANYLGERANYLATION 57 5.52e-06 4.63e-05 0.5630 -0.183000 -0.237000 -0.220000 0.249000 -0.341000 1.68e-02 1.98e-03 4.13e-03 1.14e-03 8.32e-06
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 4.23e-03 1.57e-02 0.5590 -0.257000 -0.244000 0.289000 0.031100 0.320000 1.59e-01 1.81e-01 1.14e-01 8.65e-01 7.95e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.50e-06 1.40e-05 0.5580 0.236000 0.084000 0.091900 0.474000 -0.125000 6.77e-03 3.35e-01 2.92e-01 5.48e-08 1.51e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.03e-01 1.95e-01 0.5560 -0.103000 -0.282000 -0.214000 0.321000 -0.266000 4.91e-01 5.86e-02 1.52e-01 3.14e-02 7.45e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 9.46e-04 4.34e-03 0.5560 0.337000 -0.092900 0.035700 0.383000 -0.196000 6.17e-03 4.51e-01 7.72e-01 1.86e-03 1.11e-01
SIGNALING BY FGFR4 IN DISEASE 10 3.88e-01 5.02e-01 0.5550 -0.370000 -0.197000 -0.334000 -0.098000 -0.104000 4.25e-02 2.81e-01 6.71e-02 5.91e-01 5.68e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 2.49e-03 9.95e-03 0.5550 0.114000 -0.024000 0.359000 0.124000 0.388000 3.67e-01 8.49e-01 4.45e-03 3.25e-01 2.10e-03
COMPLEX I BIOGENESIS 56 5.03e-19 2.64e-17 0.5540 0.194000 0.289000 -0.151000 -0.205000 -0.349000 1.21e-02 1.87e-04 5.13e-02 7.98e-03 6.31e-06
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.71e-13 5.51e-12 0.5530 0.293000 0.071900 -0.202000 0.170000 -0.382000 2.00e-04 3.61e-01 1.03e-02 3.11e-02 1.22e-06
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 58 4.87e-13 1.34e-11 0.5510 0.280000 0.073800 -0.219000 0.256000 -0.326000 2.24e-04 3.31e-01 3.94e-03 7.33e-04 1.80e-05
CS DS DEGRADATION 14 4.14e-02 9.74e-02 0.5500 0.097100 0.266000 0.152000 0.364000 0.257000 5.29e-01 8.44e-02 3.25e-01 1.84e-02 9.59e-02
GAP JUNCTION TRAFFICKING AND REGULATION 33 1.28e-04 7.74e-04 0.5490 0.284000 0.183000 0.268000 0.332000 -0.074200 4.79e-03 6.91e-02 7.84e-03 9.59e-04 4.61e-01
DARPP 32 EVENTS 23 2.12e-02 5.96e-02 0.5490 -0.219000 -0.206000 -0.227000 0.275000 -0.289000 6.95e-02 8.72e-02 5.98e-02 2.23e-02 1.63e-02
SIGNALING BY LEPTIN 10 2.05e-01 3.19e-01 0.5480 0.276000 0.043800 0.239000 -0.059800 0.402000 1.31e-01 8.10e-01 1.91e-01 7.43e-01 2.77e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 5.24e-02 1.19e-01 0.5480 0.207000 0.090100 -0.004800 0.398000 -0.301000 2.14e-01 5.89e-01 9.77e-01 1.71e-02 7.07e-02
MITOCHONDRIAL TRANSLATION 93 1.68e-28 1.50e-26 0.5470 0.315000 0.213000 -0.054800 0.022700 -0.389000 1.57e-07 3.81e-04 3.62e-01 7.05e-01 8.65e-11
FGFR2 LIGAND BINDING AND ACTIVATION 10 1.36e-02 4.17e-02 0.5460 -0.005240 0.265000 -0.204000 -0.315000 -0.295000 9.77e-01 1.47e-01 2.64e-01 8.46e-02 1.06e-01
INTERFERON GAMMA SIGNALING 71 2.15e-07 2.35e-06 0.5460 -0.232000 -0.231000 -0.189000 -0.308000 -0.246000 7.22e-04 7.87e-04 5.96e-03 7.03e-06 3.47e-04
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.63e-03 1.98e-02 0.5460 -0.079800 0.033600 0.264000 0.276000 0.380000 6.18e-01 8.34e-01 9.92e-02 8.52e-02 1.75e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 9.44e-02 1.82e-01 0.5430 -0.335000 -0.225000 -0.283000 0.184000 -0.135000 2.46e-02 1.32e-01 5.76e-02 2.17e-01 3.64e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.81e-13 5.64e-12 0.5400 0.327000 0.147000 -0.157000 0.146000 -0.343000 3.77e-05 6.45e-02 4.85e-02 6.69e-02 1.61e-05
GLYCOGEN SYNTHESIS 14 3.08e-02 7.85e-02 0.5400 0.139000 0.095200 -0.191000 0.431000 -0.201000 3.66e-01 5.38e-01 2.16e-01 5.22e-03 1.92e-01
RORA ACTIVATES GENE EXPRESSION 18 1.86e-03 7.89e-03 0.5370 -0.235000 -0.004060 0.140000 -0.204000 0.415000 8.49e-02 9.76e-01 3.03e-01 1.34e-01 2.28e-03
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 1.85e-02 5.31e-02 0.5370 0.199000 0.050400 0.176000 0.347000 -0.309000 2.32e-01 7.62e-01 2.91e-01 3.76e-02 6.39e-02
KERATAN SULFATE DEGRADATION 11 2.10e-01 3.26e-01 0.5370 0.327000 0.204000 0.066000 0.357000 0.087300 6.06e-02 2.41e-01 7.05e-01 4.02e-02 6.16e-01
TIGHT JUNCTION INTERACTIONS 16 3.12e-02 7.92e-02 0.5350 -0.216000 -0.281000 -0.071500 0.141000 -0.368000 1.35e-01 5.15e-02 6.21e-01 3.30e-01 1.08e-02
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 8.77e-34 1.69e-31 0.5350 0.256000 0.317000 -0.176000 -0.078900 -0.287000 5.12e-06 1.67e-08 1.78e-03 1.61e-01 3.48e-07
COLLAGEN CHAIN TRIMERIZATION 38 2.94e-04 1.63e-03 0.5340 0.128000 0.391000 0.256000 -0.162000 0.156000 1.73e-01 3.00e-05 6.38e-03 8.37e-02 9.62e-02
HSF1 DEPENDENT TRANSACTIVATION 33 4.42e-03 1.61e-02 0.5330 0.249000 0.272000 0.248000 0.282000 0.084800 1.32e-02 6.83e-03 1.37e-02 5.03e-03 3.99e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.96e-07 2.16e-06 0.5330 -0.364000 -0.194000 -0.038100 0.229000 -0.245000 1.60e-04 4.40e-02 6.93e-01 1.74e-02 1.08e-02
KINESINS 46 4.00e-04 2.16e-03 0.5310 0.225000 0.111000 0.304000 0.180000 0.308000 8.44e-03 1.92e-01 3.69e-04 3.52e-02 3.09e-04
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 1.20e-01 2.15e-01 0.5310 0.362000 0.059500 0.215000 0.133000 0.288000 1.89e-02 7.00e-01 1.64e-01 3.90e-01 6.20e-02
SULFUR AMINO ACID METABOLISM 22 8.10e-04 3.81e-03 0.5300 0.197000 0.096600 0.107000 0.376000 -0.283000 1.09e-01 4.33e-01 3.84e-01 2.26e-03 2.16e-02
PEXOPHAGY 11 4.61e-01 5.71e-01 0.5260 0.255000 0.309000 0.297000 0.101000 0.135000 1.43e-01 7.62e-02 8.80e-02 5.64e-01 4.39e-01
PROTEIN UBIQUITINATION 69 4.89e-07 5.00e-06 0.5260 -0.044000 -0.138000 -0.295000 0.197000 -0.360000 5.28e-01 4.72e-02 2.23e-05 4.64e-03 2.35e-07
CRMPS IN SEMA3A SIGNALING 16 2.40e-02 6.56e-02 0.5250 0.077200 -0.082600 0.316000 -0.211000 0.344000 5.93e-01 5.67e-01 2.85e-02 1.43e-01 1.73e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 10 6.78e-02 1.44e-01 0.5240 0.175000 0.033200 0.107000 0.054000 0.478000 3.39e-01 8.56e-01 5.59e-01 7.68e-01 8.85e-03
NOTCH HLH TRANSCRIPTION PATHWAY 28 1.74e-02 5.09e-02 0.5240 0.055100 0.222000 0.277000 -0.117000 0.362000 6.14e-01 4.22e-02 1.12e-02 2.83e-01 9.02e-04
NUCLEOBASE BIOSYNTHESIS 15 2.62e-02 6.94e-02 0.5230 0.042900 -0.050500 0.037500 0.489000 -0.171000 7.74e-01 7.35e-01 8.01e-01 1.05e-03 2.51e-01
PROTEIN METHYLATION 17 2.21e-02 6.13e-02 0.5220 0.092800 -0.002510 -0.267000 0.289000 -0.330000 5.08e-01 9.86e-01 5.68e-02 3.89e-02 1.84e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 5.79e-02 1.29e-01 0.5220 -0.279000 -0.176000 -0.235000 -0.292000 -0.150000 1.80e-02 1.36e-01 4.61e-02 1.32e-02 2.02e-01
MET ACTIVATES PTK2 SIGNALING 28 1.21e-02 3.79e-02 0.5200 0.052700 0.330000 0.196000 -0.150000 0.313000 6.29e-01 2.54e-03 7.27e-02 1.69e-01 4.14e-03
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 10 1.40e-02 4.27e-02 0.5170 -0.260000 -0.279000 0.254000 -0.049800 0.234000 1.54e-01 1.27e-01 1.65e-01 7.85e-01 2.01e-01
STABILIZATION OF P53 54 2.82e-12 6.80e-11 0.5160 0.315000 0.102000 -0.193000 0.169000 -0.302000 6.38e-05 1.97e-01 1.44e-02 3.21e-02 1.26e-04
GLUCONEOGENESIS 27 1.35e-03 5.87e-03 0.5160 0.283000 0.117000 0.246000 0.316000 -0.110000 1.11e-02 2.95e-01 2.68e-02 4.51e-03 3.23e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 9.76e-04 4.42e-03 0.5150 -0.045600 0.146000 0.314000 0.083400 0.369000 6.93e-01 2.06e-01 6.51e-03 4.70e-01 1.40e-03
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 1.22e-12 3.12e-11 0.5150 0.257000 0.083600 -0.181000 0.207000 -0.341000 4.15e-04 2.51e-01 1.29e-02 4.44e-03 2.80e-06
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 2.41e-01 3.61e-01 0.5150 0.141000 0.110000 0.358000 -0.031300 0.323000 3.62e-01 4.76e-01 2.03e-02 8.39e-01 3.65e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 8.34e-12 1.82e-10 0.5140 0.324000 0.118000 -0.142000 0.158000 -0.317000 4.56e-05 1.38e-01 7.30e-02 4.70e-02 6.70e-05
MITOTIC TELOPHASE CYTOKINESIS 13 6.47e-03 2.22e-02 0.5130 -0.214000 0.190000 -0.401000 -0.142000 0.015000 1.81e-01 2.37e-01 1.23e-02 3.76e-01 9.26e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 2.33e-03 9.53e-03 0.5120 0.260000 0.158000 0.188000 0.296000 0.216000 4.98e-03 8.78e-02 4.23e-02 1.38e-03 1.96e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.19e-01 2.14e-01 0.5110 0.186000 0.227000 -0.008160 0.334000 -0.252000 3.08e-01 2.14e-01 9.64e-01 6.77e-02 1.68e-01
INTRAFLAGELLAR TRANSPORT 49 4.51e-06 3.84e-05 0.5110 0.370000 0.073500 0.071300 0.329000 0.069300 7.35e-06 3.74e-01 3.88e-01 6.76e-05 4.02e-01
EARLY PHASE OF HIV LIFE CYCLE 13 3.81e-01 4.99e-01 0.5090 -0.185000 -0.128000 -0.339000 0.013600 -0.305000 2.47e-01 4.23e-01 3.43e-02 9.32e-01 5.70e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 1.18e-01 2.13e-01 0.5080 -0.300000 0.007270 -0.187000 0.280000 -0.232000 1.00e-01 9.68e-01 3.06e-01 1.25e-01 2.03e-01
PYRUVATE METABOLISM 27 4.64e-02 1.07e-01 0.5070 -0.156000 -0.191000 -0.241000 0.190000 -0.320000 1.60e-01 8.56e-02 3.05e-02 8.69e-02 4.03e-03
EUKARYOTIC TRANSLATION INITIATION 114 2.42e-32 3.11e-30 0.5060 0.207000 0.299000 -0.171000 -0.082300 -0.297000 1.37e-04 3.54e-08 1.63e-03 1.29e-01 4.36e-08
RECYCLING PATHWAY OF L1 40 7.17e-05 4.56e-04 0.5060 0.222000 0.077500 0.267000 0.359000 -0.008500 1.49e-02 3.96e-01 3.51e-03 8.52e-05 9.26e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 29 2.34e-04 1.31e-03 0.5060 -0.224000 -0.072800 0.065500 -0.311000 0.315000 3.68e-02 4.98e-01 5.42e-01 3.74e-03 3.35e-03
VOLTAGE GATED POTASSIUM CHANNELS 38 2.18e-10 3.82e-09 0.5050 -0.384000 -0.117000 0.137000 0.010700 0.274000 4.15e-05 2.11e-01 1.45e-01 9.09e-01 3.45e-03
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 4.71e-01 5.76e-01 0.5050 -0.315000 -0.192000 -0.329000 -0.005420 -0.104000 8.45e-02 2.94e-01 7.17e-02 9.76e-01 5.67e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.60e-14 6.15e-13 0.5050 0.165000 0.264000 -0.211000 0.037300 -0.336000 2.88e-02 4.62e-04 5.15e-03 6.20e-01 8.19e-06
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 1.74e-01 2.84e-01 0.5040 -0.273000 -0.150000 -0.147000 0.210000 -0.303000 1.02e-01 3.67e-01 3.78e-01 2.08e-01 6.96e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 9.38e-12 2.01e-10 0.5040 0.250000 0.046300 -0.192000 0.159000 -0.357000 8.97e-04 5.39e-01 1.09e-02 3.43e-02 2.15e-06
COLLAGEN FORMATION 75 3.75e-05 2.52e-04 0.5030 0.208000 0.309000 0.283000 -0.043500 0.181000 1.83e-03 3.85e-06 2.26e-05 5.15e-01 6.67e-03
HEDGEHOG LIGAND BIOGENESIS 61 4.28e-12 9.71e-11 0.5030 0.311000 0.131000 -0.156000 0.220000 -0.258000 2.61e-05 7.80e-02 3.50e-02 3.04e-03 4.95e-04
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 69 3.07e-14 1.14e-12 0.5030 0.272000 0.054600 -0.180000 0.157000 -0.345000 9.62e-05 4.33e-01 9.86e-03 2.42e-02 7.03e-07
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 1.80e-01 2.90e-01 0.5020 0.160000 0.301000 0.107000 0.216000 0.279000 3.18e-01 6.05e-02 5.03e-01 1.78e-01 8.12e-02
GLUTAMATE AND GLUTAMINE METABOLISM 13 2.31e-01 3.49e-01 0.5020 0.173000 0.292000 0.184000 0.298000 0.118000 2.80e-01 6.82e-02 2.50e-01 6.29e-02 4.62e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 34 8.52e-04 3.97e-03 0.5010 -0.021700 -0.023200 -0.268000 0.298000 -0.299000 8.27e-01 8.15e-01 6.77e-03 2.66e-03 2.52e-03
NONSENSE MEDIATED DECAY NMD 109 3.88e-30 4.48e-28 0.5010 0.200000 0.346000 -0.136000 -0.170000 -0.209000 3.18e-04 4.43e-10 1.42e-02 2.15e-03 1.69e-04
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 9.90e-03 3.22e-02 0.5000 -0.373000 0.046500 -0.059500 0.235000 0.223000 4.11e-02 7.99e-01 7.44e-01 1.98e-01 2.22e-01
SELENOAMINO ACID METABOLISM 108 1.52e-29 1.46e-27 0.4990 0.240000 0.331000 -0.140000 -0.095000 -0.232000 1.66e-05 2.90e-09 1.21e-02 8.83e-02 3.13e-05
METHYLATION 11 8.02e-02 1.61e-01 0.4990 0.074500 0.120000 -0.258000 0.168000 -0.367000 6.69e-01 4.92e-01 1.39e-01 3.35e-01 3.53e-02
RMTS METHYLATE HISTONE ARGININES 41 2.75e-03 1.08e-02 0.4950 0.241000 0.243000 0.301000 -0.136000 0.138000 7.61e-03 7.18e-03 8.49e-04 1.32e-01 1.25e-01
DEGRADATION OF AXIN 53 2.54e-11 5.15e-10 0.4950 0.304000 0.090600 -0.166000 0.128000 -0.316000 1.30e-04 2.54e-01 3.63e-02 1.06e-01 6.92e-05
LYSOSPHINGOLIPID AND LPA RECEPTORS 11 4.13e-01 5.26e-01 0.4930 -0.292000 -0.326000 -0.147000 0.035600 -0.167000 9.33e-02 6.08e-02 3.99e-01 8.38e-01 3.39e-01
PENTOSE PHOSPHATE PATHWAY 13 1.36e-01 2.37e-01 0.4920 0.045000 -0.150000 -0.108000 0.241000 -0.384000 7.79e-01 3.48e-01 4.99e-01 1.32e-01 1.64e-02
RESPIRATORY ELECTRON TRANSPORT 102 1.91e-27 1.58e-25 0.4920 0.163000 0.203000 -0.113000 -0.151000 -0.372000 4.56e-03 3.89e-04 4.85e-02 8.36e-03 8.70e-11
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 7.06e-04 3.42e-03 0.4910 0.017600 0.005110 -0.295000 0.140000 -0.366000 8.65e-01 9.61e-01 4.44e-03 1.77e-01 4.17e-04
NCAM1 INTERACTIONS 39 2.18e-03 8.97e-03 0.4900 0.047700 0.182000 0.304000 -0.219000 0.254000 6.06e-01 4.97e-02 1.03e-03 1.78e-02 6.17e-03
DEGRADATION OF DVL 55 2.37e-11 4.90e-10 0.4900 0.282000 0.118000 -0.162000 0.129000 -0.322000 3.06e-04 1.30e-01 3.75e-02 9.85e-02 3.65e-05
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 4.19e-03 1.56e-02 0.4880 -0.299000 -0.338000 -0.043700 -0.043000 0.177000 2.83e-02 1.31e-02 7.48e-01 7.52e-01 1.93e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 2.98e-12 7.03e-11 0.4860 0.301000 0.079700 -0.138000 0.115000 -0.327000 6.22e-05 2.90e-01 6.64e-02 1.25e-01 1.41e-05
DEGRADATION OF GLI1 BY THE PROTEASOME 57 7.62e-11 1.42e-09 0.4860 0.271000 0.101000 -0.172000 0.170000 -0.306000 4.03e-04 1.89e-01 2.50e-02 2.62e-02 6.31e-05
VLDLR INTERNALISATION AND DEGRADATION 12 1.74e-01 2.84e-01 0.4850 0.238000 -0.059300 0.244000 0.330000 0.080600 1.53e-01 7.22e-01 1.44e-01 4.79e-02 6.29e-01
INTERLEUKIN 20 FAMILY SIGNALING 12 2.19e-01 3.35e-01 0.4840 0.326000 0.059700 0.203000 -0.096400 0.271000 5.03e-02 7.20e-01 2.23e-01 5.63e-01 1.04e-01
TRIGLYCERIDE CATABOLISM 14 2.22e-01 3.37e-01 0.4840 -0.084300 -0.057700 -0.260000 0.210000 -0.335000 5.85e-01 7.08e-01 9.24e-02 1.75e-01 2.99e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 9.59e-02 1.84e-01 0.4840 -0.252000 -0.395000 -0.093100 -0.015000 -0.075700 8.15e-02 6.19e-03 5.19e-01 9.17e-01 6.00e-01
CHOLESTEROL BIOSYNTHESIS 24 3.76e-04 2.05e-03 0.4830 0.290000 -0.098600 -0.193000 0.245000 -0.206000 1.38e-02 4.03e-01 1.01e-01 3.79e-02 8.11e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 20 2.06e-02 5.81e-02 0.4830 -0.317000 -0.310000 -0.057800 0.089900 -0.159000 1.42e-02 1.64e-02 6.55e-01 4.87e-01 2.17e-01
ANCHORING FIBRIL FORMATION 13 4.03e-01 5.18e-01 0.4820 0.070600 0.216000 0.243000 -0.177000 0.299000 6.59e-01 1.78e-01 1.29e-01 2.68e-01 6.17e-02
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 1.10e-02 3.50e-02 0.4810 0.339000 -0.008090 0.264000 0.174000 -0.130000 1.28e-02 9.53e-01 5.29e-02 2.01e-01 3.40e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 3.23e-03 1.26e-02 0.4810 -0.200000 -0.233000 -0.286000 -0.152000 0.179000 1.42e-01 8.64e-02 3.60e-02 2.65e-01 1.89e-01
RUNX3 REGULATES NOTCH SIGNALING 13 3.68e-02 9.04e-02 0.4800 -0.180000 0.003900 0.285000 -0.128000 0.317000 2.60e-01 9.81e-01 7.52e-02 4.23e-01 4.78e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 80 1.56e-14 6.15e-13 0.4800 0.246000 0.029000 -0.195000 0.164000 -0.322000 1.43e-04 6.54e-01 2.54e-03 1.11e-02 6.56e-07
PRE NOTCH PROCESSING IN GOLGI 17 2.19e-01 3.35e-01 0.4790 0.138000 0.215000 0.325000 0.119000 0.211000 3.25e-01 1.26e-01 2.02e-02 3.97e-01 1.31e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 9.38e-02 1.81e-01 0.4780 0.287000 0.142000 0.149000 0.203000 -0.249000 9.89e-02 4.15e-01 3.91e-01 2.43e-01 1.53e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 5.74e-01 6.61e-01 0.4750 -0.174000 -0.256000 -0.243000 0.120000 -0.238000 2.97e-01 1.25e-01 1.45e-01 4.72e-01 1.54e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 3.61e-02 8.95e-02 0.4740 0.099700 -0.170000 -0.219000 0.130000 -0.348000 4.52e-01 2.01e-01 9.82e-02 3.25e-01 8.63e-03
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 1.33e-02 4.12e-02 0.4730 -0.001300 0.338000 0.218000 0.128000 0.214000 9.92e-01 6.10e-03 7.65e-02 3.00e-01 8.19e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.04e-02 3.36e-02 0.4730 -0.180000 -0.231000 -0.216000 -0.229000 -0.197000 4.85e-02 1.15e-02 1.83e-02 1.24e-02 3.14e-02
P75NTR SIGNALS VIA NF KB 15 4.08e-01 5.20e-01 0.4710 0.208000 0.322000 0.203000 -0.035900 0.182000 1.63e-01 3.11e-02 1.74e-01 8.10e-01 2.23e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.12e-01 3.28e-01 0.4710 -0.145000 -0.172000 -0.220000 -0.256000 -0.239000 3.14e-01 2.34e-01 1.27e-01 7.60e-02 9.86e-02
GLYCOGEN METABOLISM 25 4.28e-03 1.58e-02 0.4710 0.155000 0.198000 -0.048900 0.392000 0.047300 1.80e-01 8.67e-02 6.72e-01 6.92e-04 6.82e-01
DERMATAN SULFATE BIOSYNTHESIS 11 1.95e-01 3.07e-01 0.4700 0.047200 0.188000 0.148000 0.308000 0.258000 7.86e-01 2.81e-01 3.94e-01 7.68e-02 1.38e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 5.53e-04 2.76e-03 0.4700 -0.055300 -0.105000 -0.268000 0.141000 -0.339000 4.99e-01 2.01e-01 1.05e-03 8.38e-02 3.38e-05
SCAVENGING BY CLASS A RECEPTORS 13 7.43e-02 1.53e-01 0.4700 0.151000 0.440000 0.017200 0.056300 0.013800 3.45e-01 5.97e-03 9.14e-01 7.25e-01 9.31e-01
INSULIN RECEPTOR RECYCLING 20 3.67e-02 9.04e-02 0.4700 0.073600 -0.107000 -0.081400 0.301000 -0.326000 5.69e-01 4.07e-01 5.28e-01 1.97e-02 1.17e-02
OLFACTORY SIGNALING PATHWAY 21 8.79e-03 2.94e-02 0.4690 -0.200000 -0.008560 -0.244000 -0.329000 0.111000 1.13e-01 9.46e-01 5.25e-02 9.12e-03 3.77e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 2.08e-03 8.66e-03 0.4690 0.167000 0.071800 0.348000 0.207000 0.152000 8.81e-02 4.62e-01 3.70e-04 3.37e-02 1.20e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 1.33e-01 2.35e-01 0.4680 0.160000 0.333000 0.213000 -0.040200 0.190000 1.74e-01 4.77e-03 7.09e-02 7.33e-01 1.08e-01
TRANSLATION 286 5.73e-62 6.62e-59 0.4680 0.263000 0.225000 -0.103000 0.063700 -0.290000 2.22e-14 6.27e-11 2.69e-03 6.44e-02 3.60e-17
CALNEXIN CALRETICULIN CYCLE 26 2.56e-03 1.02e-02 0.4670 0.076800 0.009150 -0.144000 0.436000 -0.038800 4.98e-01 9.36e-01 2.04e-01 1.21e-04 7.32e-01
LDL CLEARANCE 16 1.20e-01 2.16e-01 0.4660 0.189000 0.041300 0.074800 0.418000 0.008970 1.91e-01 7.75e-01 6.04e-01 3.82e-03 9.50e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 3.97e-02 9.44e-02 0.4660 -0.367000 -0.183000 -0.087300 -0.199000 -0.043300 2.32e-03 1.28e-01 4.69e-01 9.88e-02 7.19e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 1.02e-01 1.93e-01 0.4650 -0.185000 -0.228000 -0.203000 0.101000 -0.282000 8.42e-02 3.40e-02 5.92e-02 3.46e-01 8.67e-03
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 5.28e-02 1.20e-01 0.4650 0.075800 -0.195000 -0.215000 0.104000 -0.340000 5.67e-01 1.42e-01 1.04e-01 4.31e-01 1.03e-02
TRNA AMINOACYLATION 42 9.54e-04 4.36e-03 0.4650 0.305000 0.195000 0.066600 0.283000 -0.006250 6.17e-04 2.91e-02 4.55e-01 1.48e-03 9.44e-01
REPRESSION OF WNT TARGET GENES 14 7.13e-02 1.49e-01 0.4650 0.116000 0.233000 0.381000 -0.030400 0.043400 4.52e-01 1.31e-01 1.36e-02 8.44e-01 7.78e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 2.25e-09 3.38e-08 0.4640 0.148000 -0.025000 -0.191000 0.114000 -0.379000 4.13e-02 7.29e-01 8.18e-03 1.16e-01 1.61e-07
SUPPRESSION OF PHAGOSOMAL MATURATION 12 2.09e-01 3.25e-01 0.4630 0.149000 0.039000 -0.045300 0.372000 -0.225000 3.71e-01 8.15e-01 7.86e-01 2.56e-02 1.78e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 8.18e-02 1.63e-01 0.4630 0.162000 0.000988 -0.051000 0.268000 -0.337000 2.94e-01 9.95e-01 7.41e-01 8.31e-02 2.88e-02
REGULATION OF IFNG SIGNALING 13 6.60e-02 1.40e-01 0.4630 0.122000 -0.294000 -0.228000 0.210000 -0.128000 4.45e-01 6.61e-02 1.55e-01 1.90e-01 4.25e-01
FORMATION OF THE CORNIFIED ENVELOPE 22 3.82e-02 9.21e-02 0.4620 0.307000 0.057600 0.283000 0.190000 -0.007100 1.28e-02 6.40e-01 2.17e-02 1.23e-01 9.54e-01
KERATINIZATION 22 3.82e-02 9.21e-02 0.4620 0.307000 0.057600 0.283000 0.190000 -0.007100 1.28e-02 6.40e-01 2.17e-02 1.23e-01 9.54e-01
PROCESSING OF SMDT1 16 7.23e-02 1.50e-01 0.4620 0.140000 -0.177000 -0.195000 0.180000 -0.303000 3.34e-01 2.19e-01 1.76e-01 2.13e-01 3.60e-02
INTERLEUKIN 6 SIGNALING 10 2.32e-01 3.49e-01 0.4610 0.220000 -0.022900 0.157000 0.114000 0.355000 2.29e-01 9.00e-01 3.89e-01 5.32e-01 5.19e-02
NRAGE SIGNALS DEATH THROUGH JNK 54 1.90e-06 1.69e-05 0.4610 -0.043700 0.109000 0.339000 -0.062900 0.283000 5.78e-01 1.67e-01 1.67e-05 4.24e-01 3.24e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.22e-29 1.29e-27 0.4610 0.163000 0.209000 -0.101000 -0.124000 -0.341000 1.68e-03 5.58e-05 5.15e-02 1.71e-02 4.38e-11
N GLYCAN ANTENNAE ELONGATION 15 5.21e-02 1.19e-01 0.4600 -0.008910 -0.161000 0.058800 0.393000 -0.167000 9.52e-01 2.79e-01 6.93e-01 8.43e-03 2.64e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 2.57e-03 1.02e-02 0.4600 -0.099600 0.075100 0.178000 -0.228000 0.335000 3.29e-01 4.62e-01 8.11e-02 2.56e-02 1.05e-03
ECM PROTEOGLYCANS 64 1.53e-04 9.05e-04 0.4600 0.058400 0.300000 0.202000 -0.094700 0.261000 4.19e-01 3.35e-05 5.21e-03 1.91e-01 3.08e-04
PI 3K CASCADE FGFR2 15 1.09e-01 2.00e-01 0.4580 -0.217000 0.070200 -0.217000 -0.259000 -0.209000 1.46e-01 6.38e-01 1.45e-01 8.19e-02 1.61e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 34 4.83e-04 2.48e-03 0.4580 -0.099300 -0.056700 0.221000 -0.259000 0.284000 3.16e-01 5.67e-01 2.55e-02 9.00e-03 4.17e-03
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 49 4.10e-04 2.20e-03 0.4580 0.135000 0.335000 0.244000 -0.094100 0.104000 1.02e-01 5.04e-05 3.09e-03 2.55e-01 2.10e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 2.88e-01 4.11e-01 0.4570 0.177000 0.178000 0.255000 0.261000 0.113000 2.35e-01 2.34e-01 8.72e-02 7.97e-02 4.48e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 2.63e-11 5.24e-10 0.4570 0.120000 -0.039800 -0.206000 0.130000 -0.366000 5.43e-02 5.24e-01 9.52e-04 3.77e-02 4.67e-09
PHOSPHORYLATION OF THE APC C 17 2.25e-02 6.23e-02 0.4570 0.147000 -0.124000 -0.227000 0.028600 -0.345000 2.94e-01 3.77e-01 1.05e-01 8.38e-01 1.37e-02
ATTENUATION PHASE 23 1.36e-01 2.37e-01 0.4560 0.247000 0.262000 0.158000 0.219000 0.074500 4.03e-02 2.95e-02 1.91e-01 6.94e-02 5.36e-01
MITOCHONDRIAL PROTEIN IMPORT 63 6.60e-11 1.25e-09 0.4560 0.261000 0.093900 -0.022000 0.133000 -0.336000 3.48e-04 1.98e-01 7.63e-01 6.78e-02 4.08e-06
ORC1 REMOVAL FROM CHROMATIN 67 4.15e-09 6.07e-08 0.4560 0.131000 -0.005120 -0.210000 0.133000 -0.358000 6.31e-02 9.42e-01 2.93e-03 6.01e-02 3.92e-07
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 12 6.57e-02 1.40e-01 0.4540 -0.204000 -0.042400 0.259000 -0.165000 0.262000 2.22e-01 7.99e-01 1.20e-01 3.21e-01 1.16e-01
PHASE 0 RAPID DEPOLARISATION 28 1.14e-04 7.01e-04 0.4540 -0.324000 -0.136000 0.093800 -0.128000 0.239000 3.03e-03 2.14e-01 3.90e-01 2.40e-01 2.83e-02
UNWINDING OF DNA 12 1.03e-01 1.95e-01 0.4520 -0.070100 -0.219000 0.010900 0.109000 -0.373000 6.74e-01 1.89e-01 9.48e-01 5.11e-01 2.51e-02
FERTILIZATION 12 1.29e-01 2.30e-01 0.4510 -0.090000 0.317000 -0.022900 -0.232000 0.200000 5.89e-01 5.71e-02 8.91e-01 1.63e-01 2.31e-01
SODIUM CALCIUM EXCHANGERS 10 4.28e-01 5.39e-01 0.4490 -0.379000 -0.175000 -0.138000 -0.087000 -0.028700 3.78e-02 3.38e-01 4.50e-01 6.34e-01 8.75e-01
PURINE SALVAGE 12 2.55e-01 3.76e-01 0.4490 0.128000 -0.002190 -0.091300 0.399000 -0.133000 4.41e-01 9.90e-01 5.84e-01 1.67e-02 4.24e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 5.60e-04 2.78e-03 0.4480 0.185000 0.025700 -0.066000 0.203000 -0.347000 7.89e-02 8.08e-01 5.32e-01 5.46e-02 1.00e-03
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 5.06e-35 1.33e-32 0.4480 0.219000 0.261000 -0.150000 -0.034800 -0.247000 1.88e-06 1.32e-08 1.05e-03 4.48e-01 7.50e-08
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 11 3.61e-01 4.83e-01 0.4470 0.105000 0.295000 0.098000 0.203000 0.225000 5.48e-01 9.07e-02 5.74e-01 2.43e-01 1.96e-01
CRISTAE FORMATION 31 2.67e-05 1.84e-04 0.4460 0.135000 0.126000 -0.118000 0.035200 -0.386000 1.94e-01 2.24e-01 2.54e-01 7.35e-01 1.96e-04
INTERLEUKIN 12 SIGNALING 36 1.53e-03 6.55e-03 0.4460 0.036000 -0.016600 -0.242000 0.167000 -0.333000 7.09e-01 8.63e-01 1.21e-02 8.27e-02 5.54e-04
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 2.20e-01 3.36e-01 0.4430 0.054900 0.120000 0.285000 0.110000 0.293000 7.13e-01 4.23e-01 5.62e-02 4.60e-01 4.92e-02
REGULATION OF PTEN STABILITY AND ACTIVITY 66 1.19e-09 1.89e-08 0.4430 0.236000 0.062200 -0.156000 0.186000 -0.279000 9.01e-04 3.83e-01 2.81e-02 8.96e-03 9.16e-05
COPI MEDIATED ANTEROGRADE TRANSPORT 90 4.56e-09 6.59e-08 0.4430 0.211000 -0.006450 0.156000 0.350000 -0.068300 5.47e-04 9.16e-01 1.08e-02 9.28e-09 2.63e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 10 7.59e-02 1.55e-01 0.4430 -0.045900 0.304000 -0.086300 -0.228000 -0.206000 8.01e-01 9.65e-02 6.36e-01 2.11e-01 2.60e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 4.70e-11 9.20e-10 0.4420 0.193000 0.021400 -0.150000 0.202000 -0.307000 2.24e-03 7.35e-01 1.73e-02 1.36e-03 1.20e-06
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 7.73e-04 3.68e-03 0.4420 0.114000 0.021700 -0.133000 0.400000 -0.064300 2.42e-01 8.24e-01 1.75e-01 4.23e-05 5.11e-01
PI 3K CASCADE FGFR4 10 3.40e-01 4.62e-01 0.4410 -0.258000 0.045000 -0.294000 -0.193000 -0.045000 1.57e-01 8.05e-01 1.07e-01 2.90e-01 8.05e-01
HDMS DEMETHYLATE HISTONES 26 5.42e-03 1.93e-02 0.4410 -0.238000 -0.090700 0.121000 -0.311000 0.135000 3.57e-02 4.23e-01 2.85e-01 6.14e-03 2.34e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 3.93e-01 5.07e-01 0.4410 -0.243000 -0.180000 -0.295000 0.102000 -0.072400 1.45e-01 2.81e-01 7.70e-02 5.39e-01 6.64e-01
JOSEPHIN DOMAIN DUBS 11 3.83e-01 5.00e-01 0.4400 0.283000 0.297000 0.124000 0.098200 -0.024800 1.04e-01 8.86e-02 4.77e-01 5.73e-01 8.87e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 19 5.44e-02 1.22e-01 0.4400 0.060200 -0.206000 -0.008520 0.361000 -0.133000 6.50e-01 1.21e-01 9.49e-01 6.51e-03 3.17e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.58e-01 2.67e-01 0.4400 0.053700 -0.157000 -0.223000 0.341000 0.010800 7.69e-01 3.91e-01 2.23e-01 6.16e-02 9.53e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 10 4.23e-01 5.34e-01 0.4400 -0.340000 -0.116000 -0.053300 -0.245000 -0.032700 6.25e-02 5.24e-01 7.70e-01 1.80e-01 8.58e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 1.37e-01 2.39e-01 0.4390 0.245000 0.018500 0.312000 -0.185000 0.032700 1.42e-01 9.11e-01 6.10e-02 2.67e-01 8.45e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 5.57e-02 1.24e-01 0.4390 -0.032600 0.080300 0.313000 -0.133000 0.265000 8.01e-01 5.34e-01 1.54e-02 3.04e-01 4.06e-02
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 2.36e-02 6.48e-02 0.4390 0.193000 0.279000 0.113000 -0.129000 -0.220000 2.29e-01 8.20e-02 4.82e-01 4.20e-01 1.69e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 3.89e-01 5.03e-01 0.4360 0.162000 -0.039300 0.095800 0.392000 0.006890 3.76e-01 8.29e-01 6.00e-01 3.19e-02 9.70e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 2.37e-03 9.59e-03 0.4360 -0.198000 -0.071000 0.164000 -0.129000 -0.320000 2.01e-01 6.46e-01 2.89e-01 4.02e-01 3.81e-02
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 7.02e-02 1.47e-01 0.4360 0.040000 0.046200 0.179000 0.235000 0.315000 7.82e-01 7.49e-01 2.16e-01 1.04e-01 2.93e-02
SYNTHESIS OF PE 12 2.78e-01 4.00e-01 0.4350 0.188000 -0.030300 0.191000 0.244000 0.239000 2.60e-01 8.56e-01 2.53e-01 1.43e-01 1.51e-01
HSF1 ACTIVATION 25 2.41e-02 6.58e-02 0.4350 0.257000 0.124000 0.026600 0.297000 -0.138000 2.59e-02 2.82e-01 8.18e-01 1.02e-02 2.34e-01
PI3K EVENTS IN ERBB2 SIGNALING 14 1.82e-01 2.93e-01 0.4350 -0.374000 -0.118000 -0.064200 -0.176000 0.002700 1.53e-02 4.46e-01 6.77e-01 2.53e-01 9.86e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.38e-02 4.20e-02 0.4330 -0.077900 0.069900 0.341000 -0.244000 0.027900 6.01e-01 6.39e-01 2.21e-02 1.02e-01 8.52e-01
GLYCOSPHINGOLIPID METABOLISM 38 9.30e-04 4.30e-03 0.4330 0.115000 -0.030700 0.064300 0.385000 -0.143000 2.21e-01 7.43e-01 4.93e-01 4.01e-05 1.26e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 5.25e-02 1.19e-01 0.4320 -0.233000 -0.018800 0.115000 -0.069200 0.338000 1.45e-01 9.07e-01 4.73e-01 6.66e-01 3.49e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 6.76e-02 1.43e-01 0.4320 0.025600 0.179000 -0.053600 0.371000 0.118000 8.68e-01 2.46e-01 7.28e-01 1.63e-02 4.44e-01
RAP1 SIGNALLING 15 1.02e-01 1.94e-01 0.4320 -0.192000 -0.245000 -0.078000 0.283000 -0.062100 1.97e-01 1.01e-01 6.01e-01 5.82e-02 6.77e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 5.99e-02 1.32e-01 0.4320 0.213000 -0.041900 0.063700 0.351000 -0.111000 9.16e-02 7.39e-01 6.14e-01 5.37e-03 3.78e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 2.64e-01 3.86e-01 0.4320 -0.332000 -0.273000 -0.002730 -0.041700 -0.013900 6.93e-02 1.35e-01 9.88e-01 8.19e-01 9.39e-01
KILLING MECHANISMS 10 3.42e-01 4.64e-01 0.4310 0.122000 0.108000 0.154000 -0.359000 0.083500 5.04e-01 5.54e-01 3.98e-01 4.95e-02 6.47e-01
DNA REPLICATION PRE INITIATION 79 1.94e-09 2.99e-08 0.4310 0.140000 -0.036100 -0.183000 0.139000 -0.335000 3.19e-02 5.79e-01 4.86e-03 3.31e-02 2.64e-07
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 1.34e-01 2.35e-01 0.4310 -0.068700 -0.108000 -0.285000 0.023100 -0.296000 5.68e-01 3.68e-01 1.79e-02 8.48e-01 1.41e-02
FATTY ACYL COA BIOSYNTHESIS 32 2.50e-03 9.95e-03 0.4310 -0.097200 0.050500 -0.192000 0.323000 -0.179000 3.41e-01 6.21e-01 5.97e-02 1.57e-03 7.91e-02
INTERFERON SIGNALING 158 5.76e-09 8.12e-08 0.4300 -0.206000 -0.198000 -0.160000 -0.206000 -0.187000 8.12e-06 1.75e-05 5.25e-04 7.82e-06 5.25e-05
FORMATION OF APOPTOSOME 10 5.96e-01 6.80e-01 0.4290 -0.104000 -0.160000 -0.150000 0.237000 -0.262000 5.69e-01 3.82e-01 4.11e-01 1.94e-01 1.51e-01
AMINE LIGAND BINDING RECEPTORS 27 1.25e-05 9.61e-05 0.4290 -0.233000 -0.248000 0.180000 0.181000 0.049500 3.60e-02 2.56e-02 1.06e-01 1.03e-01 6.57e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 2.32e-01 3.49e-01 0.4280 0.030600 -0.087800 -0.198000 0.201000 -0.307000 8.32e-01 5.43e-01 1.70e-01 1.64e-01 3.34e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 4.82e-01 5.85e-01 0.4270 0.257000 0.182000 0.227000 -0.017900 0.178000 5.96e-02 1.81e-01 9.48e-02 8.95e-01 1.91e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 3.51e-03 1.35e-02 0.4270 0.128000 -0.170000 -0.168000 0.043400 -0.328000 2.40e-01 1.21e-01 1.24e-01 6.91e-01 2.70e-03
BUDDING AND MATURATION OF HIV VIRION 27 5.02e-03 1.81e-02 0.4270 0.201000 0.045100 -0.020100 0.242000 -0.284000 7.09e-02 6.85e-01 8.57e-01 2.94e-02 1.06e-02
CELLULAR HEXOSE TRANSPORT 11 6.57e-02 1.40e-01 0.4270 0.102000 -0.175000 0.371000 0.011700 0.055100 5.57e-01 3.16e-01 3.30e-02 9.47e-01 7.52e-01
HS GAG DEGRADATION 20 4.06e-02 9.60e-02 0.4260 0.290000 -0.017100 0.132000 0.096600 0.265000 2.49e-02 8.95e-01 3.07e-01 4.55e-01 4.01e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 3.61e-03 1.39e-02 0.4260 0.127000 0.150000 -0.092300 -0.101000 -0.352000 3.50e-01 2.69e-01 4.98e-01 4.57e-01 9.83e-03
LAMININ INTERACTIONS 27 2.46e-02 6.67e-02 0.4250 -0.084700 0.158000 0.203000 -0.254000 0.208000 4.46e-01 1.56e-01 6.81e-02 2.23e-02 6.19e-02
BIOTIN TRANSPORT AND METABOLISM 11 6.34e-01 7.13e-01 0.4250 0.174000 0.242000 0.231000 -0.136000 0.142000 3.18e-01 1.65e-01 1.84e-01 4.34e-01 4.15e-01
PYRIMIDINE SALVAGE 10 1.04e-01 1.96e-01 0.4240 0.249000 -0.290000 0.137000 0.091400 0.081700 1.74e-01 1.12e-01 4.52e-01 6.17e-01 6.54e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 4.71e-01 5.76e-01 0.4240 -0.219000 -0.164000 -0.040600 -0.277000 -0.162000 2.31e-01 3.69e-01 8.24e-01 1.29e-01 3.74e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.47e-02 4.44e-02 0.4240 0.065200 -0.089900 -0.051300 0.233000 -0.332000 5.65e-01 4.28e-01 6.51e-01 3.96e-02 3.42e-03
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 4.24e-01 5.35e-01 0.4230 0.192000 0.058200 0.075800 0.349000 0.106000 2.69e-01 7.38e-01 6.63e-01 4.50e-02 5.44e-01
G1 S DNA DAMAGE CHECKPOINTS 65 1.48e-09 2.32e-08 0.4220 0.242000 0.079300 -0.170000 0.144000 -0.254000 7.63e-04 2.69e-01 1.81e-02 4.48e-02 4.08e-04
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.53e-02 6.78e-02 0.4220 -0.311000 0.029900 -0.029300 0.273000 -0.073200 5.23e-02 8.52e-01 8.55e-01 8.86e-02 6.48e-01
GABA RECEPTOR ACTIVATION 52 4.25e-05 2.83e-04 0.4220 -0.204000 -0.201000 -0.181000 0.248000 -0.035300 1.09e-02 1.20e-02 2.39e-02 1.97e-03 6.60e-01
DISEASES OF CARBOHYDRATE METABOLISM 28 6.83e-02 1.44e-01 0.4210 0.335000 0.106000 0.147000 0.168000 0.064000 2.18e-03 3.32e-01 1.78e-01 1.24e-01 5.58e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 6.55e-05 4.20e-04 0.4210 0.152000 0.100000 -0.115000 0.350000 -0.091900 6.59e-02 2.26e-01 1.65e-01 2.28e-05 2.66e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 2.03e-03 8.50e-03 0.4200 0.139000 -0.175000 0.169000 0.309000 -0.051200 1.96e-01 1.03e-01 1.16e-01 4.01e-03 6.34e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 1.66e-01 2.76e-01 0.4200 -0.176000 -0.231000 -0.186000 -0.052100 -0.233000 7.96e-02 2.15e-02 6.43e-02 6.05e-01 2.07e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 3.18e-02 8.01e-02 0.4170 0.185000 -0.150000 -0.160000 0.114000 -0.280000 1.63e-01 2.58e-01 2.26e-01 3.91e-01 3.44e-02
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 1.93e-01 3.06e-01 0.4170 0.057300 -0.089900 -0.117000 0.256000 -0.288000 6.83e-01 5.21e-01 4.02e-01 6.80e-02 3.96e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.48e-09 3.67e-08 0.4160 0.316000 0.076600 -0.073700 0.106000 -0.226000 1.72e-05 2.97e-01 3.16e-01 1.49e-01 2.10e-03
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 1.03e-02 3.34e-02 0.4150 -0.197000 -0.224000 -0.046000 0.102000 -0.266000 5.79e-02 3.08e-02 6.58e-01 3.26e-01 1.03e-02
HEME SIGNALING 44 5.29e-04 2.64e-03 0.4150 -0.295000 -0.154000 -0.043300 -0.214000 0.119000 7.20e-04 7.79e-02 6.19e-01 1.39e-02 1.73e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 12 1.63e-01 2.72e-01 0.4150 0.177000 0.250000 -0.084500 0.202000 -0.174000 2.89e-01 1.33e-01 6.12e-01 2.25e-01 2.97e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 2.17e-08 2.83e-07 0.4140 0.133000 0.003860 -0.202000 0.181000 -0.283000 4.31e-02 9.53e-01 2.01e-03 5.75e-03 1.52e-05
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 4.67e-01 5.74e-01 0.4140 -0.176000 -0.194000 -0.203000 0.183000 -0.167000 2.37e-01 1.92e-01 1.73e-01 2.20e-01 2.64e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.62e-02 4.81e-02 0.4140 0.091400 -0.018600 -0.170000 -0.049500 -0.362000 4.79e-01 8.85e-01 1.87e-01 7.02e-01 5.02e-03
ELASTIC FIBRE FORMATION 35 4.30e-02 1.01e-01 0.4130 0.102000 0.305000 0.215000 -0.011800 0.145000 2.97e-01 1.82e-03 2.78e-02 9.04e-01 1.37e-01
S PHASE 153 3.37e-14 1.22e-12 0.4130 0.054600 -0.066200 -0.207000 0.105000 -0.330000 2.45e-01 1.58e-01 1.00e-05 2.54e-02 1.77e-12
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 7.48e-04 3.59e-03 0.4130 -0.012800 -0.065500 -0.118000 0.305000 -0.243000 8.75e-01 4.19e-01 1.44e-01 1.69e-04 2.67e-03
CELLULAR RESPONSE TO HYPOXIA 71 8.64e-10 1.39e-08 0.4120 0.211000 0.073800 -0.147000 0.117000 -0.291000 2.12e-03 2.82e-01 3.28e-02 8.74e-02 2.19e-05
LYSINE CATABOLISM 10 4.85e-01 5.87e-01 0.4120 0.130000 0.133000 0.090700 0.297000 0.198000 4.76e-01 4.68e-01 6.19e-01 1.04e-01 2.79e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 11 6.82e-01 7.49e-01 0.4120 -0.182000 -0.292000 -0.193000 -0.049400 -0.107000 2.95e-01 9.33e-02 2.69e-01 7.76e-01 5.37e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 3.07e-03 1.20e-02 0.4110 0.191000 -0.053100 0.169000 0.277000 -0.158000 7.07e-02 6.15e-01 1.09e-01 8.69e-03 1.35e-01
DNA REPLICATION 121 2.72e-13 8.29e-12 0.4110 0.122000 -0.047800 -0.178000 0.113000 -0.328000 2.07e-02 3.65e-01 7.22e-04 3.21e-02 4.66e-10
SELECTIVE AUTOPHAGY 71 1.34e-05 1.03e-04 0.4110 0.227000 0.162000 0.086600 0.275000 -0.093200 9.71e-04 1.82e-02 2.07e-01 6.32e-05 1.75e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 48 1.04e-03 4.62e-03 0.4110 0.037800 0.022400 0.270000 -0.060400 0.301000 6.50e-01 7.88e-01 1.23e-03 4.70e-01 3.04e-04
FCERI MEDIATED NF KB ACTIVATION 76 5.73e-09 8.12e-08 0.4110 0.180000 0.050700 -0.163000 0.180000 -0.274000 6.71e-03 4.45e-01 1.40e-02 6.75e-03 3.60e-05
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 28 1.17e-02 3.68e-02 0.4110 0.044800 -0.098300 -0.181000 -0.009790 -0.353000 6.82e-01 3.68e-01 9.76e-02 9.29e-01 1.24e-03
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 3.51e-03 1.35e-02 0.4100 0.237000 0.046300 -0.024300 0.322000 -0.073300 1.13e-02 6.21e-01 7.96e-01 5.92e-04 4.34e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 15 2.85e-02 7.48e-02 0.4100 -0.212000 0.141000 0.170000 0.040300 0.270000 1.56e-01 3.44e-01 2.55e-01 7.87e-01 7.01e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 9.20e-02 1.78e-01 0.4100 0.105000 0.187000 0.313000 -0.139000 -0.065900 5.29e-01 2.62e-01 6.03e-02 4.03e-01 6.93e-01
HDR THROUGH MMEJ ALT NHEJ 10 1.30e-01 2.31e-01 0.4100 -0.350000 0.177000 -0.048200 -0.107000 -0.011200 5.52e-02 3.32e-01 7.92e-01 5.59e-01 9.51e-01
OTHER SEMAPHORIN INTERACTIONS 19 2.88e-02 7.51e-02 0.4090 -0.166000 -0.112000 0.110000 -0.157000 0.301000 2.10e-01 4.00e-01 4.05e-01 2.35e-01 2.32e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.21e-01 5.32e-01 0.4090 -0.200000 -0.148000 -0.069000 0.217000 -0.232000 2.74e-01 4.19e-01 7.06e-01 2.35e-01 2.04e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 1.01e-01 1.93e-01 0.4080 -0.157000 -0.319000 0.168000 0.092400 0.056200 3.90e-01 8.08e-02 3.57e-01 6.13e-01 7.58e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 4.04e-03 1.51e-02 0.4070 -0.056900 0.071100 0.154000 -0.152000 0.332000 5.44e-01 4.48e-01 9.98e-02 1.05e-01 3.92e-04
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 2.95e-02 7.61e-02 0.4070 0.309000 0.179000 0.181000 -0.046200 -0.060000 1.04e-02 1.38e-01 1.33e-01 7.01e-01 6.18e-01
SIGNALING BY BMP 24 1.02e-01 1.94e-01 0.4060 -0.268000 -0.177000 -0.239000 0.053900 -0.030900 2.30e-02 1.33e-01 4.23e-02 6.48e-01 7.93e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 4.24e-03 1.57e-02 0.4040 -0.159000 -0.153000 -0.019600 0.260000 0.217000 2.31e-01 2.48e-01 8.82e-01 4.97e-02 1.02e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 2.51e-02 6.75e-02 0.4040 -0.038700 -0.179000 -0.160000 -0.151000 -0.286000 7.14e-01 9.06e-02 1.30e-01 1.52e-01 6.72e-03
EXTRA NUCLEAR ESTROGEN SIGNALING 65 1.61e-04 9.37e-04 0.4040 -0.186000 -0.146000 -0.132000 0.225000 -0.197000 9.37e-03 4.17e-02 6.68e-02 1.68e-03 5.99e-03
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 5.28e-01 6.24e-01 0.4030 -0.237000 -0.015600 -0.201000 -0.156000 -0.203000 1.56e-01 9.25e-01 2.29e-01 3.48e-01 2.23e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 4.17e-01 5.29e-01 0.4020 -0.183000 -0.210000 -0.164000 0.182000 -0.158000 2.06e-01 1.47e-01 2.57e-01 2.08e-01 2.75e-01
SHC1 EVENTS IN EGFR SIGNALING 10 4.72e-01 5.76e-01 0.4020 -0.295000 -0.129000 -0.114000 0.127000 -0.170000 1.06e-01 4.78e-01 5.32e-01 4.86e-01 3.52e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 2.94e-01 4.16e-01 0.4020 -0.182000 -0.151000 -0.171000 0.244000 -0.132000 2.08e-01 2.97e-01 2.38e-01 9.17e-02 3.62e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 5.99e-03 2.08e-02 0.4010 -0.218000 -0.209000 0.047300 0.001130 0.260000 9.19e-02 1.06e-01 7.14e-01 9.93e-01 4.41e-02
CHAPERONE MEDIATED AUTOPHAGY 19 2.79e-02 7.35e-02 0.4010 0.262000 0.221000 -0.048800 0.109000 -0.170000 4.84e-02 9.54e-02 7.13e-01 4.09e-01 1.99e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 3.63e-02 8.98e-02 0.4010 -0.026600 0.193000 -0.072100 0.261000 0.222000 8.58e-01 1.95e-01 6.29e-01 8.04e-02 1.37e-01
REGULATION OF RAS BY GAPS 66 8.20e-08 9.57e-07 0.4010 0.213000 0.052900 -0.146000 0.166000 -0.252000 2.78e-03 4.57e-01 3.99e-02 1.96e-02 4.12e-04
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 67 4.03e-08 4.95e-07 0.4000 0.150000 0.043500 -0.204000 0.099500 -0.291000 3.44e-02 5.38e-01 3.97e-03 1.59e-01 3.83e-05
DSCAM INTERACTIONS 10 2.79e-01 4.00e-01 0.4000 -0.270000 -0.073100 0.125000 -0.242000 0.084300 1.39e-01 6.89e-01 4.94e-01 1.85e-01 6.44e-01
PROTEIN LOCALIZATION 156 1.36e-15 5.83e-14 0.3990 0.153000 -0.011300 -0.060100 0.226000 -0.284000 9.54e-04 8.08e-01 1.96e-01 1.13e-06 8.97e-10
LATE ENDOSOMAL MICROAUTOPHAGY 30 7.98e-03 2.67e-02 0.3990 0.275000 0.162000 0.060200 0.167000 -0.159000 9.10e-03 1.24e-01 5.68e-01 1.13e-01 1.32e-01
DNA DAMAGE BYPASS 45 9.33e-03 3.09e-02 0.3990 -0.047900 -0.213000 -0.189000 -0.089600 -0.260000 5.79e-01 1.37e-02 2.82e-02 2.99e-01 2.55e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA 12 2.42e-01 3.62e-01 0.3980 0.019700 -0.185000 0.067700 0.333000 -0.094100 9.06e-01 2.68e-01 6.85e-01 4.60e-02 5.73e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 1.74e-01 2.84e-01 0.3980 -0.034100 -0.150000 -0.138000 0.152000 -0.304000 7.77e-01 2.14e-01 2.51e-01 2.08e-01 1.15e-02
DEADENYLATION OF MRNA 25 2.23e-01 3.37e-01 0.3980 -0.223000 -0.141000 -0.223000 0.123000 -0.154000 5.36e-02 2.22e-01 5.40e-02 2.86e-01 1.82e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 5.78e-03 2.01e-02 0.3980 -0.287000 -0.201000 0.085000 -0.026800 0.166000 2.29e-02 1.11e-01 5.00e-01 8.31e-01 1.89e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 2.17e-01 3.33e-01 0.3970 -0.143000 0.159000 -0.175000 0.136000 -0.251000 4.10e-01 3.62e-01 3.15e-01 4.34e-01 1.50e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 3.90e-01 5.03e-01 0.3970 0.219000 0.082200 0.224000 0.229000 0.016300 1.43e-01 5.82e-01 1.33e-01 1.25e-01 9.13e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 7.01e-01 7.65e-01 0.3970 0.162000 0.200000 0.248000 -0.064600 0.159000 3.11e-01 2.12e-01 1.21e-01 6.87e-01 3.22e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 23 2.71e-02 7.14e-02 0.3960 0.089500 -0.167000 0.096000 0.306000 -0.135000 4.58e-01 1.66e-01 4.26e-01 1.10e-02 2.64e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 10 1.95e-01 3.07e-01 0.3960 0.207000 -0.211000 0.239000 -0.059900 0.095200 2.58e-01 2.49e-01 1.90e-01 7.43e-01 6.02e-01
PURINE CATABOLISM 16 7.75e-02 1.57e-01 0.3950 -0.014000 0.165000 -0.208000 0.113000 -0.270000 9.23e-01 2.53e-01 1.49e-01 4.34e-01 6.18e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 1.09e-01 2.00e-01 0.3950 -0.372000 0.012700 0.052100 -0.119000 -0.029400 3.27e-02 9.42e-01 7.65e-01 4.93e-01 8.66e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 6.89e-02 1.45e-01 0.3940 0.166000 -0.025200 -0.007340 0.312000 -0.174000 1.59e-01 8.31e-01 9.50e-01 8.25e-03 1.41e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 11 1.12e-01 2.05e-01 0.3940 -0.044000 0.207000 0.173000 0.277000 -0.060500 8.01e-01 2.35e-01 3.19e-01 1.11e-01 7.28e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 1.73e-01 2.84e-01 0.3940 -0.020600 -0.145000 -0.150000 -0.227000 -0.245000 8.87e-01 3.15e-01 3.00e-01 1.16e-01 9.03e-02
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 84 5.19e-06 4.38e-05 0.3940 0.208000 -0.020100 0.162000 0.288000 0.052000 1.02e-03 7.50e-01 1.05e-02 5.22e-06 4.10e-01
CELLULAR RESPONSE TO STARVATION 145 5.07e-24 3.66e-22 0.3940 0.173000 0.241000 -0.097300 -0.050200 -0.234000 3.24e-04 5.54e-07 4.34e-02 2.97e-01 1.15e-06
P75NTR RECRUITS SIGNALLING COMPLEXES 12 6.44e-01 7.21e-01 0.3930 0.159000 0.303000 0.149000 -0.006650 0.124000 3.41e-01 6.88e-02 3.72e-01 9.68e-01 4.56e-01
IRON UPTAKE AND TRANSPORT 51 2.07e-03 8.65e-03 0.3930 0.057000 -0.111000 -0.120000 0.261000 -0.238000 4.81e-01 1.72e-01 1.38e-01 1.28e-03 3.25e-03
TRANSCRIPTIONAL REGULATION BY MECP2 58 1.55e-05 1.17e-04 0.3920 -0.254000 -0.119000 -0.012200 -0.199000 0.188000 8.11e-04 1.17e-01 8.73e-01 8.92e-03 1.34e-02
CHONDROITIN SULFATE BIOSYNTHESIS 18 6.20e-02 1.35e-01 0.3920 0.050100 -0.077000 0.233000 0.226000 0.200000 7.13e-01 5.72e-01 8.68e-02 9.71e-02 1.43e-01
SIGNALING BY HIPPO 20 7.01e-02 1.47e-01 0.3910 -0.232000 -0.220000 -0.179000 0.130000 0.039800 7.25e-02 8.82e-02 1.65e-01 3.13e-01 7.58e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 25 6.29e-02 1.36e-01 0.3900 -0.015700 -0.154000 -0.050700 0.329000 -0.134000 8.92e-01 1.84e-01 6.61e-01 4.46e-03 2.45e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 14 3.81e-01 4.99e-01 0.3900 -0.264000 -0.149000 -0.026400 -0.238000 -0.053500 8.77e-02 3.35e-01 8.64e-01 1.23e-01 7.29e-01
PEROXISOMAL PROTEIN IMPORT 57 5.25e-04 2.64e-03 0.3890 0.077200 -0.100000 -0.069400 0.293000 -0.212000 3.14e-01 1.91e-01 3.65e-01 1.33e-04 5.64e-03
THE NLRP3 INFLAMMASOME 14 6.03e-02 1.33e-01 0.3890 0.132000 -0.173000 -0.092100 -0.219000 -0.217000 3.91e-01 2.62e-01 5.51e-01 1.55e-01 1.59e-01
RRNA PROCESSING 194 1.16e-32 1.67e-30 0.3890 0.207000 0.230000 -0.098300 -0.086300 -0.195000 6.82e-07 3.30e-08 1.85e-02 3.84e-02 2.78e-06
MITOCHONDRIAL TRNA AMINOACYLATION 21 2.33e-01 3.50e-01 0.3880 0.271000 0.018200 0.173000 0.188000 0.108000 3.13e-02 8.85e-01 1.70e-01 1.37e-01 3.90e-01
HEDGEHOG OFF STATE 106 4.09e-07 4.29e-06 0.3880 0.273000 0.134000 0.047100 0.236000 0.000869 1.16e-06 1.71e-02 4.02e-01 2.71e-05 9.88e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 24 7.93e-03 2.67e-02 0.3880 -0.033600 -0.078100 0.190000 0.117000 0.305000 7.76e-01 5.08e-01 1.07e-01 3.21e-01 9.66e-03
GLUTATHIONE CONJUGATION 29 1.97e-03 8.31e-03 0.3870 0.104000 0.060000 -0.018000 0.131000 -0.343000 3.30e-01 5.76e-01 8.67e-01 2.22e-01 1.38e-03
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.69e-01 4.89e-01 0.3870 0.104000 -0.175000 -0.136000 0.241000 -0.178000 5.15e-01 2.75e-01 3.94e-01 1.33e-01 2.67e-01
ANTIGEN PROCESSING CROSS PRESENTATION 93 1.24e-12 3.12e-11 0.3860 0.170000 0.087700 -0.203000 0.051600 -0.262000 4.63e-03 1.44e-01 7.18e-04 3.90e-01 1.30e-05
ABC TRANSPORTER DISORDERS 68 6.22e-07 6.10e-06 0.3860 0.217000 0.095500 -0.114000 0.206000 -0.192000 1.95e-03 1.73e-01 1.04e-01 3.35e-03 6.17e-03
PEROXISOMAL LIPID METABOLISM 26 8.08e-02 1.62e-01 0.3850 0.069200 -0.043200 -0.113000 0.310000 -0.180000 5.41e-01 7.03e-01 3.18e-01 6.15e-03 1.12e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 5.32e-01 6.27e-01 0.3850 0.223000 0.150000 0.205000 -0.079600 0.167000 1.02e-01 2.72e-01 1.33e-01 5.59e-01 2.19e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 1.79e-01 2.90e-01 0.3850 -0.116000 -0.270000 0.072200 0.211000 -0.108000 4.87e-01 1.05e-01 6.65e-01 2.05e-01 5.18e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 4.16e-01 5.28e-01 0.3840 -0.021300 0.065600 -0.229000 0.140000 -0.266000 9.03e-01 7.06e-01 1.88e-01 4.22e-01 1.26e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.25e-02 1.50e-01 0.3840 0.037700 -0.214000 0.117000 0.256000 0.146000 8.01e-01 1.52e-01 4.32e-01 8.64e-02 3.29e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 1.43e-02 4.33e-02 0.3830 0.173000 -0.053200 -0.157000 0.068900 -0.291000 1.42e-01 6.52e-01 1.84e-01 5.59e-01 1.36e-02
INTERLEUKIN 12 FAMILY SIGNALING 42 3.98e-03 1.50e-02 0.3830 0.003030 0.025700 -0.206000 0.164000 -0.277000 9.73e-01 7.73e-01 2.08e-02 6.60e-02 1.91e-03
LONG TERM POTENTIATION 23 1.52e-03 6.55e-03 0.3820 -0.276000 -0.170000 0.137000 0.034600 0.143000 2.18e-02 1.59e-01 2.56e-01 7.74e-01 2.34e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 2.51e-02 6.75e-02 0.3820 0.137000 0.182000 -0.092700 0.165000 -0.241000 2.65e-01 1.41e-01 4.52e-01 1.81e-01 5.07e-02
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 6.81e-01 7.49e-01 0.3810 0.052000 0.236000 0.218000 0.024400 0.198000 7.65e-01 1.76e-01 2.12e-01 8.89e-01 2.55e-01
MITOPHAGY 29 9.98e-03 3.23e-02 0.3800 0.104000 0.142000 -0.055200 0.226000 -0.244000 3.32e-01 1.85e-01 6.07e-01 3.56e-02 2.32e-02
REGULATION OF BACH1 ACTIVITY 11 5.55e-01 6.47e-01 0.3790 0.005840 -0.048300 -0.212000 0.099400 -0.294000 9.73e-01 7.81e-01 2.24e-01 5.68e-01 9.10e-02
ADHERENS JUNCTIONS INTERACTIONS 29 1.84e-02 5.31e-02 0.3790 -0.234000 -0.252000 -0.135000 0.070100 0.050400 2.94e-02 1.90e-02 2.08e-01 5.14e-01 6.39e-01
PI 3K CASCADE FGFR1 14 2.64e-01 3.86e-01 0.3780 -0.171000 0.069700 -0.142000 -0.215000 -0.206000 2.67e-01 6.52e-01 3.58e-01 1.64e-01 1.82e-01
PHASE II CONJUGATION OF COMPOUNDS 60 2.18e-05 1.55e-04 0.3780 0.037200 0.004920 -0.099800 0.130000 -0.338000 6.18e-01 9.47e-01 1.81e-01 8.08e-02 5.93e-06
ERKS ARE INACTIVATED 13 1.14e-01 2.07e-01 0.3780 -0.053100 -0.134000 0.104000 0.236000 -0.235000 7.40e-01 4.02e-01 5.18e-01 1.40e-01 1.43e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 7.59e-03 2.56e-02 0.3770 -0.294000 0.116000 -0.054600 0.158000 0.119000 3.07e-02 3.93e-01 6.89e-01 2.45e-01 3.81e-01
NUCLEAR ENVELOPE NE REASSEMBLY 63 1.34e-04 8.00e-04 0.3770 0.145000 0.068200 0.035200 0.306000 -0.147000 4.68e-02 3.50e-01 6.29e-01 2.69e-05 4.31e-02
HIV TRANSCRIPTION INITIATION 45 6.27e-04 3.07e-03 0.3760 0.006350 -0.025000 -0.168000 -0.058900 -0.331000 9.41e-01 7.71e-01 5.13e-02 4.94e-01 1.25e-04
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 3.15e-01 4.38e-01 0.3760 -0.160000 -0.142000 -0.160000 0.210000 -0.161000 2.16e-01 2.72e-01 2.16e-01 1.03e-01 2.14e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 5.88e-02 1.30e-01 0.3750 0.002360 0.237000 0.065300 0.181000 0.219000 9.85e-01 5.46e-02 5.96e-01 1.43e-01 7.57e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 6.05e-02 1.33e-01 0.3740 0.121000 0.066200 0.013600 -0.334000 -0.094900 4.01e-01 6.47e-01 9.25e-01 2.07e-02 5.11e-01
GOLGI TO ER RETROGRADE TRANSPORT 117 5.60e-08 6.74e-07 0.3740 0.164000 -0.016100 0.086200 0.324000 0.001920 2.23e-03 7.63e-01 1.07e-01 1.39e-09 9.71e-01
CDC42 GTPASE CYCLE 151 1.17e-11 2.45e-10 0.3740 -0.056800 0.156000 0.226000 -0.043200 0.243000 2.29e-01 9.36e-04 1.66e-06 3.60e-01 2.60e-07
CELL CELL JUNCTION ORGANIZATION 47 3.76e-03 1.43e-02 0.3740 -0.221000 -0.275000 -0.081000 0.074900 -0.056100 8.83e-03 1.12e-03 3.37e-01 3.74e-01 5.06e-01
CD28 CO STIMULATION 30 1.16e-01 2.12e-01 0.3730 -0.072100 -0.228000 -0.141000 0.203000 -0.145000 4.95e-01 3.08e-02 1.83e-01 5.38e-02 1.69e-01
INFLUENZA INFECTION 145 2.87e-22 1.75e-20 0.3730 0.120000 0.209000 -0.128000 -0.148000 -0.207000 1.24e-02 1.41e-05 8.11e-03 2.15e-03 1.79e-05
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 4.25e-03 1.57e-02 0.3730 0.128000 0.004550 0.199000 0.203000 0.204000 1.26e-01 9.57e-01 1.69e-02 1.51e-02 1.44e-02
MITOTIC G1 PHASE AND G1 S TRANSITION 140 3.24e-10 5.51e-09 0.3720 0.067700 -0.056100 -0.155000 0.153000 -0.288000 1.67e-01 2.52e-01 1.52e-03 1.83e-03 3.89e-09
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 1.05e-01 1.96e-01 0.3720 0.167000 -0.081600 0.023100 0.102000 -0.304000 2.62e-01 5.84e-01 8.77e-01 4.94e-01 4.13e-02
COPII MEDIATED VESICLE TRANSPORT 64 8.53e-06 6.80e-05 0.3720 0.020400 -0.190000 0.047900 0.238000 -0.206000 7.78e-01 8.50e-03 5.08e-01 9.80e-04 4.38e-03
RHOBTB2 GTPASE CYCLE 23 2.96e-02 7.61e-02 0.3720 -0.060500 0.149000 -0.208000 0.220000 -0.143000 6.16e-01 2.17e-01 8.37e-02 6.77e-02 2.35e-01
COLLAGEN DEGRADATION 49 7.05e-03 2.40e-02 0.3710 0.068800 0.299000 0.173000 -0.050500 0.105000 4.05e-01 2.88e-04 3.63e-02 5.41e-01 2.05e-01
DISEASES OF DNA REPAIR 11 2.33e-01 3.50e-01 0.3700 0.145000 0.248000 -0.114000 0.169000 0.113000 4.07e-01 1.54e-01 5.11e-01 3.31e-01 5.16e-01
RNA POLYMERASE III CHAIN ELONGATION 18 1.86e-02 5.31e-02 0.3700 0.225000 0.097600 -0.030500 -0.054700 -0.269000 9.79e-02 4.73e-01 8.23e-01 6.88e-01 4.80e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 4.98e-23 3.20e-21 0.3690 0.106000 0.133000 -0.107000 -0.007900 -0.309000 1.71e-02 2.63e-03 1.59e-02 8.58e-01 2.66e-12
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.11e-01 3.26e-01 0.3680 -0.133000 -0.320000 -0.004740 -0.009650 -0.126000 3.44e-01 2.26e-02 9.73e-01 9.45e-01 3.68e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 304 5.74e-35 1.33e-32 0.3680 0.194000 0.182000 -0.087300 0.128000 -0.203000 6.47e-09 5.46e-08 8.99e-03 1.33e-04 1.31e-09
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 6.21e-02 1.35e-01 0.3680 0.281000 0.005660 -0.051000 0.023500 -0.231000 5.99e-02 9.70e-01 7.32e-01 8.75e-01 1.22e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.05e-01 1.97e-01 0.3680 0.003930 -0.047200 -0.155000 0.326000 -0.050800 9.75e-01 7.08e-01 2.19e-01 9.71e-03 6.87e-01
PKMTS METHYLATE HISTONE LYSINES 47 5.37e-03 1.91e-02 0.3670 -0.072900 0.012000 0.104000 -0.294000 0.179000 3.88e-01 8.87e-01 2.17e-01 4.79e-04 3.40e-02
RA BIOSYNTHESIS PATHWAY 10 3.02e-01 4.25e-01 0.3670 0.287000 -0.018600 -0.034400 0.104000 -0.199000 1.16e-01 9.19e-01 8.50e-01 5.71e-01 2.75e-01
ANTIMICROBIAL PEPTIDES 12 4.26e-01 5.37e-01 0.3660 0.296000 0.177000 0.056400 0.091100 -0.056600 7.58e-02 2.88e-01 7.35e-01 5.85e-01 7.34e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 1.37e-01 2.39e-01 0.3650 -0.215000 -0.113000 0.116000 0.075600 0.235000 2.17e-01 5.17e-01 5.04e-01 6.64e-01 1.77e-01
TNFR2 NON CANONICAL NF KB PATHWAY 78 1.06e-08 1.44e-07 0.3650 0.228000 0.113000 -0.061300 0.093200 -0.237000 5.06e-04 8.52e-02 3.50e-01 1.55e-01 3.07e-04
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 4.96e-02 1.13e-01 0.3640 -0.251000 -0.237000 0.000138 0.115000 0.002890 5.16e-02 6.63e-02 9.99e-01 3.72e-01 9.82e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 83 5.54e-10 9.14e-09 0.3640 0.175000 0.051000 -0.150000 0.022200 -0.276000 5.82e-03 4.22e-01 1.79e-02 7.26e-01 1.38e-05
PCP CE PATHWAY 89 2.58e-08 3.27e-07 0.3640 0.275000 0.086200 -0.005470 0.147000 -0.167000 7.54e-06 1.60e-01 9.29e-01 1.63e-02 6.42e-03
CARGO CONCENTRATION IN THE ER 30 2.07e-02 5.82e-02 0.3640 -0.020600 -0.149000 0.025200 0.268000 -0.193000 8.46e-01 1.58e-01 8.11e-01 1.10e-02 6.76e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 3.34e-03 1.30e-02 0.3640 0.156000 0.043300 -0.020000 0.140000 -0.294000 1.20e-01 6.67e-01 8.42e-01 1.65e-01 3.51e-03
TIE2 SIGNALING 17 2.30e-01 3.47e-01 0.3640 -0.249000 0.012000 -0.225000 0.098700 -0.098800 7.54e-02 9.31e-01 1.08e-01 4.81e-01 4.81e-01
PEPTIDE HORMONE METABOLISM 57 2.03e-03 8.50e-03 0.3630 -0.080900 -0.131000 -0.262000 0.168000 -0.106000 2.91e-01 8.65e-02 6.28e-04 2.86e-02 1.65e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 7.27e-08 8.66e-07 0.3630 0.168000 0.050800 -0.108000 0.134000 -0.267000 8.62e-03 4.26e-01 9.05e-02 3.58e-02 2.95e-05
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 3.62e-01 4.84e-01 0.3620 -0.096700 -0.046900 -0.033100 -0.344000 -0.009580 5.17e-01 7.53e-01 8.24e-01 2.10e-02 9.49e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 3.07e-01 4.30e-01 0.3620 0.115000 0.096800 0.003640 0.204000 -0.258000 4.89e-01 5.61e-01 9.83e-01 2.22e-01 1.21e-01
UNFOLDED PROTEIN RESPONSE UPR 84 5.03e-04 2.56e-03 0.3620 0.251000 0.128000 0.104000 0.202000 0.008120 7.26e-05 4.28e-02 9.98e-02 1.38e-03 8.98e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 25 2.37e-03 9.59e-03 0.3620 0.101000 0.110000 -0.032300 -0.156000 -0.288000 3.82e-01 3.41e-01 7.80e-01 1.76e-01 1.27e-02
METAL ION SLC TRANSPORTERS 24 1.45e-02 4.39e-02 0.3610 -0.286000 -0.125000 -0.094300 0.128000 0.088100 1.53e-02 2.88e-01 4.24e-01 2.78e-01 4.55e-01
INTERLEUKIN 7 SIGNALING 19 1.17e-01 2.12e-01 0.3610 0.141000 -0.063000 0.128000 -0.128000 0.271000 2.89e-01 6.35e-01 3.36e-01 3.35e-01 4.05e-02
COMPLEMENT CASCADE 22 3.97e-02 9.44e-02 0.3600 0.034600 0.338000 -0.046700 -0.036600 0.106000 7.79e-01 6.12e-03 7.04e-01 7.66e-01 3.90e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 31 1.25e-01 2.23e-01 0.3600 0.069900 0.290000 0.147000 -0.034600 0.133000 5.00e-01 5.14e-03 1.57e-01 7.39e-01 2.00e-01
RHOB GTPASE CYCLE 66 6.24e-05 4.05e-04 0.3590 -0.075700 0.137000 0.180000 -0.015500 0.269000 2.88e-01 5.51e-02 1.16e-02 8.28e-01 1.62e-04
PI 3K CASCADE FGFR3 12 2.72e-01 3.92e-01 0.3590 -0.208000 0.182000 -0.173000 -0.149000 -0.023400 2.13e-01 2.76e-01 3.00e-01 3.72e-01 8.89e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 19 1.48e-01 2.53e-01 0.3590 0.088300 -0.235000 -0.017300 0.238000 -0.093600 5.05e-01 7.57e-02 8.96e-01 7.31e-02 4.80e-01
HYALURONAN METABOLISM 15 3.08e-01 4.31e-01 0.3590 0.096000 -0.036200 0.185000 0.119000 0.264000 5.20e-01 8.08e-01 2.15e-01 4.24e-01 7.71e-02
TELOMERE C STRAND SYNTHESIS INITIATION 13 3.49e-01 4.70e-01 0.3580 0.099700 0.100000 -0.083700 0.219000 -0.231000 5.34e-01 5.32e-01 6.01e-01 1.71e-01 1.50e-01
SIGNALING BY HEDGEHOG 141 4.30e-07 4.48e-06 0.3580 0.219000 0.122000 0.066500 0.242000 0.046200 7.05e-06 1.23e-02 1.74e-01 7.25e-07 3.45e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 139 6.15e-11 1.18e-09 0.3580 0.134000 -0.051300 0.121000 0.285000 -0.107000 6.40e-03 2.97e-01 1.35e-02 6.60e-09 3.02e-02
RAF ACTIVATION 34 2.97e-02 7.62e-02 0.3580 -0.018000 -0.114000 -0.023700 0.286000 -0.180000 8.56e-01 2.51e-01 8.11e-01 3.95e-03 6.91e-02
SHC MEDIATED CASCADE FGFR4 10 4.08e-01 5.20e-01 0.3580 -0.081400 0.078000 -0.310000 0.066300 -0.122000 6.56e-01 6.69e-01 8.99e-02 7.16e-01 5.06e-01
CA DEPENDENT EVENTS 36 8.32e-05 5.23e-04 0.3570 -0.255000 -0.143000 0.043500 0.169000 0.109000 8.16e-03 1.39e-01 6.52e-01 7.99e-02 2.57e-01
NEUREXINS AND NEUROLIGINS 54 1.06e-05 8.42e-05 0.3570 -0.155000 0.033600 0.168000 -0.000782 0.272000 4.90e-02 6.69e-01 3.25e-02 9.92e-01 5.46e-04
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 167 1.00e-13 3.50e-12 0.3570 0.112000 -0.080600 0.108000 0.289000 -0.115000 1.26e-02 7.28e-02 1.58e-02 1.28e-10 1.02e-02
TRANSLESION SYNTHESIS BY POLK 17 2.49e-01 3.70e-01 0.3560 -0.052200 -0.017700 -0.178000 -0.153000 -0.262000 7.10e-01 8.99e-01 2.03e-01 2.74e-01 6.15e-02
AUTOPHAGY 137 7.25e-09 1.01e-07 0.3560 0.186000 0.089600 0.060800 0.257000 -0.118000 1.76e-04 7.06e-02 2.20e-01 2.01e-07 1.70e-02
G PROTEIN BETA GAMMA SIGNALLING 30 2.93e-01 4.16e-01 0.3560 -0.146000 -0.178000 -0.135000 0.090700 -0.217000 1.67e-01 9.08e-02 2.01e-01 3.90e-01 4.00e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 49 2.36e-03 9.59e-03 0.3560 -0.013500 0.062100 0.175000 -0.291000 0.083700 8.70e-01 4.52e-01 3.39e-02 4.25e-04 3.11e-01
PREGNENOLONE BIOSYNTHESIS 12 3.61e-01 4.83e-01 0.3550 0.305000 0.147000 0.088100 -0.050900 -0.029100 6.69e-02 3.77e-01 5.97e-01 7.60e-01 8.62e-01
SPRY REGULATION OF FGF SIGNALING 16 3.21e-01 4.43e-01 0.3550 0.135000 -0.031700 0.124000 0.298000 -0.047000 3.48e-01 8.26e-01 3.89e-01 3.90e-02 7.45e-01
ERBB2 ACTIVATES PTK6 SIGNALING 10 2.99e-01 4.22e-01 0.3540 -0.317000 -0.071400 0.060600 -0.081000 0.097000 8.22e-02 6.96e-01 7.40e-01 6.57e-01 5.95e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 3.03e-01 4.26e-01 0.3540 -0.156000 -0.024400 -0.058000 0.265000 -0.164000 3.29e-01 8.79e-01 7.17e-01 9.81e-02 3.07e-01
INTERLEUKIN 10 SIGNALING 16 6.52e-01 7.27e-01 0.3540 -0.204000 -0.088400 -0.172000 -0.183000 -0.112000 1.58e-01 5.40e-01 2.33e-01 2.05e-01 4.38e-01
HYALURONAN UPTAKE AND DEGRADATION 11 5.27e-01 6.24e-01 0.3530 0.142000 -0.046300 0.044700 0.309000 0.069400 4.14e-01 7.90e-01 7.97e-01 7.58e-02 6.90e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 3.47e-02 8.68e-02 0.3530 -0.029600 -0.168000 -0.151000 -0.147000 -0.225000 7.55e-01 7.79e-02 1.11e-01 1.22e-01 1.77e-02
SIGNALING BY ERBB2 ECD MUTANTS 16 5.65e-01 6.57e-01 0.3520 -0.272000 -0.080900 -0.186000 -0.061900 -0.072700 5.97e-02 5.75e-01 1.98e-01 6.68e-01 6.15e-01
NGF STIMULATED TRANSCRIPTION 36 3.04e-04 1.67e-03 0.3520 -0.037300 -0.127000 0.074200 0.068100 -0.310000 6.99e-01 1.87e-01 4.41e-01 4.80e-01 1.30e-03
GRB2 EVENTS IN ERBB2 SIGNALING 14 7.25e-01 7.85e-01 0.3510 -0.241000 -0.184000 -0.149000 -0.009910 -0.095500 1.19e-01 2.34e-01 3.36e-01 9.49e-01 5.36e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 3.57e-01 4.80e-01 0.3500 0.108000 -0.076400 0.262000 -0.021800 0.191000 4.85e-01 6.21e-01 8.98e-02 8.88e-01 2.17e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 6.07e-02 1.33e-01 0.3500 -0.152000 0.073600 0.192000 0.039700 0.236000 2.63e-01 5.89e-01 1.58e-01 7.70e-01 8.37e-02
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 3.44e-01 4.66e-01 0.3500 -0.040800 0.281000 0.121000 0.020200 0.164000 7.92e-01 6.91e-02 4.33e-01 8.96e-01 2.88e-01
RAS PROCESSING 24 3.77e-02 9.17e-02 0.3500 0.083800 0.054900 -0.070100 0.107000 -0.309000 4.77e-01 6.42e-01 5.53e-01 3.63e-01 8.71e-03
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 4.31e-01 5.42e-01 0.3490 0.059900 -0.059800 -0.085900 0.266000 -0.191000 6.78e-01 6.79e-01 5.52e-01 6.54e-02 1.86e-01
DAG AND IP3 SIGNALING 40 1.97e-05 1.42e-04 0.3490 -0.242000 -0.079300 0.077300 0.118000 0.193000 8.21e-03 3.86e-01 3.98e-01 1.97e-01 3.50e-02
ENOS ACTIVATION 11 6.75e-01 7.45e-01 0.3480 -0.168000 -0.074000 -0.123000 0.130000 -0.235000 3.35e-01 6.71e-01 4.78e-01 4.54e-01 1.76e-01
ZINC TRANSPORTERS 15 2.03e-01 3.17e-01 0.3480 -0.313000 -0.091800 -0.099100 0.063800 0.034400 3.61e-02 5.38e-01 5.06e-01 6.69e-01 8.18e-01
PLASMA LIPOPROTEIN CLEARANCE 26 2.94e-01 4.16e-01 0.3480 0.210000 0.051800 0.143000 0.217000 0.080800 6.34e-02 6.47e-01 2.07e-01 5.56e-02 4.76e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 3.58e-02 8.94e-02 0.3470 -0.123000 -0.064600 -0.043700 0.312000 -0.047200 2.78e-01 5.69e-01 7.00e-01 5.97e-03 6.77e-01
SYNTHESIS OF PA 29 1.72e-01 2.83e-01 0.3460 0.127000 0.051700 0.166000 0.194000 0.188000 2.35e-01 6.30e-01 1.21e-01 7.05e-02 7.98e-02
RESOLUTION OF D LOOP STRUCTURES 30 1.59e-01 2.67e-01 0.3460 -0.149000 -0.109000 -0.083300 -0.278000 -0.034700 1.57e-01 3.03e-01 4.30e-01 8.43e-03 7.42e-01
POLYMERASE SWITCHING 14 1.01e-01 1.93e-01 0.3450 0.190000 0.084200 -0.065600 -0.064700 -0.259000 2.18e-01 5.86e-01 6.71e-01 6.75e-01 9.31e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 2.63e-01 3.85e-01 0.3450 0.105000 0.123000 0.226000 0.087300 0.184000 3.05e-01 2.28e-01 2.67e-02 3.93e-01 7.24e-02
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 20 1.48e-01 2.53e-01 0.3450 -0.103000 0.091100 -0.196000 -0.050300 -0.242000 4.25e-01 4.81e-01 1.29e-01 6.97e-01 6.06e-02
RHOBTB1 GTPASE CYCLE 23 4.08e-02 9.61e-02 0.3440 -0.148000 0.096200 -0.277000 0.084300 -0.057500 2.20e-01 4.25e-01 2.14e-02 4.84e-01 6.33e-01
RHOC GTPASE CYCLE 72 8.13e-05 5.14e-04 0.3440 -0.047600 0.159000 0.131000 0.022500 0.270000 4.85e-01 1.99e-02 5.53e-02 7.42e-01 7.28e-05
GP1B IX V ACTIVATION SIGNALLING 10 7.46e-01 8.02e-01 0.3430 -0.025400 0.125000 0.176000 -0.100000 0.246000 8.90e-01 4.95e-01 3.35e-01 5.84e-01 1.79e-01
INTERLEUKIN 15 SIGNALING 12 2.79e-01 4.00e-01 0.3410 -0.020500 -0.119000 0.005470 -0.179000 0.264000 9.02e-01 4.74e-01 9.74e-01 2.82e-01 1.13e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 6.01e-02 1.32e-01 0.3410 0.174000 -0.046000 -0.126000 0.047100 -0.257000 1.68e-01 7.15e-01 3.17e-01 7.09e-01 4.17e-02
NUCLEOTIDE SALVAGE 21 1.60e-01 2.69e-01 0.3410 0.223000 -0.092900 0.049100 0.236000 -0.007740 7.73e-02 4.61e-01 6.97e-01 6.17e-02 9.51e-01
PROTEIN FOLDING 88 2.76e-05 1.89e-04 0.3400 0.178000 0.098000 0.008970 0.241000 -0.128000 3.94e-03 1.12e-01 8.84e-01 9.18e-05 3.85e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 32 3.76e-01 4.96e-01 0.3400 -0.088000 -0.181000 -0.191000 0.045500 -0.191000 3.89e-01 7.65e-02 6.21e-02 6.56e-01 6.12e-02
FORMATION OF INCISION COMPLEX IN GG NER 43 8.78e-02 1.73e-01 0.3400 -0.108000 -0.069500 -0.162000 0.097700 -0.252000 2.22e-01 4.30e-01 6.68e-02 2.68e-01 4.33e-03
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 5.69e-01 6.60e-01 0.3400 -0.042200 -0.103000 -0.211000 0.100000 -0.220000 7.57e-01 4.48e-01 1.22e-01 4.62e-01 1.06e-01
PYROPTOSIS 20 3.46e-01 4.68e-01 0.3390 -0.028400 -0.051800 -0.189000 0.016000 -0.275000 8.26e-01 6.89e-01 1.43e-01 9.02e-01 3.34e-02
DCC MEDIATED ATTRACTIVE SIGNALING 14 1.43e-01 2.47e-01 0.3390 -0.295000 -0.110000 0.048100 -0.010700 0.117000 5.63e-02 4.77e-01 7.55e-01 9.45e-01 4.48e-01
FCERI MEDIATED MAPK ACTIVATION 28 7.82e-02 1.58e-01 0.3390 -0.214000 -0.033800 -0.114000 0.149000 -0.181000 5.02e-02 7.57e-01 2.96e-01 1.73e-01 9.72e-02
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 7.97e-01 8.41e-01 0.3390 -0.081400 -0.133000 -0.243000 0.089200 -0.153000 6.40e-01 4.44e-01 1.63e-01 6.08e-01 3.79e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 6.24e-02 1.35e-01 0.3380 -0.266000 0.010100 -0.082300 0.188000 -0.042100 4.50e-02 9.39e-01 5.35e-01 1.57e-01 7.51e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.78e-01 4.98e-01 0.3380 -0.261000 -0.148000 -0.137000 -0.007300 0.075700 9.11e-02 3.38e-01 3.76e-01 9.62e-01 6.24e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 4.70e-01 5.76e-01 0.3380 0.179000 0.272000 0.053000 0.043600 -0.059300 2.83e-01 1.03e-01 7.51e-01 7.94e-01 7.22e-01
REGULATION OF IFNA SIGNALING 12 1.60e-01 2.69e-01 0.3380 0.183000 -0.199000 0.057900 -0.148000 0.125000 2.73e-01 2.33e-01 7.28e-01 3.73e-01 4.54e-01
CTLA4 INHIBITORY SIGNALING 20 3.18e-01 4.39e-01 0.3370 0.028100 -0.087900 -0.051500 0.284000 -0.148000 8.28e-01 4.96e-01 6.90e-01 2.77e-02 2.53e-01
RHO GTPASES ACTIVATE ROCKS 19 2.16e-01 3.33e-01 0.3370 0.023800 0.312000 0.042200 -0.072600 0.093800 8.58e-01 1.86e-02 7.50e-01 5.84e-01 4.79e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 80 8.95e-08 1.01e-06 0.3360 0.169000 0.017200 -0.083700 0.038300 -0.274000 8.90e-03 7.90e-01 1.96e-01 5.54e-01 2.23e-05
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 1.86e-01 2.98e-01 0.3350 -0.107000 -0.196000 -0.190000 -0.113000 0.117000 4.74e-01 1.89e-01 2.02e-01 4.49e-01 4.32e-01
G PROTEIN MEDIATED EVENTS 51 1.82e-06 1.64e-05 0.3350 -0.253000 -0.059800 0.033800 0.132000 0.163000 1.81e-03 4.60e-01 6.76e-01 1.03e-01 4.45e-02
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 5.40e-01 6.35e-01 0.3350 -0.120000 -0.018400 -0.027900 -0.280000 0.135000 4.53e-01 9.09e-01 8.62e-01 8.02e-02 4.01e-01
HDACS DEACETYLATE HISTONES 44 1.14e-02 3.60e-02 0.3350 0.011700 0.142000 0.199000 -0.217000 0.071700 8.93e-01 1.03e-01 2.26e-02 1.28e-02 4.11e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 8.30e-01 8.70e-01 0.3350 0.210000 0.097500 0.155000 0.036500 0.182000 2.08e-01 5.59e-01 3.52e-01 8.27e-01 2.75e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 24 2.26e-01 3.42e-01 0.3350 -0.042300 -0.224000 -0.196000 0.119000 -0.086100 7.20e-01 5.77e-02 9.69e-02 3.11e-01 4.65e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 5.65e-03 1.98e-02 0.3340 -0.217000 -0.124000 0.031800 0.220000 0.003160 4.72e-02 2.57e-01 7.71e-01 4.41e-02 9.77e-01
EPHRIN SIGNALING 19 2.66e-01 3.87e-01 0.3340 0.134000 -0.085000 0.096700 0.277000 0.017100 3.11e-01 5.22e-01 4.65e-01 3.68e-02 8.97e-01
SIGNAL AMPLIFICATION 29 1.30e-01 2.30e-01 0.3330 -0.014800 -0.044700 -0.099700 0.289000 -0.123000 8.90e-01 6.77e-01 3.53e-01 7.01e-03 2.52e-01
EFFECTS OF PIP2 HYDROLYSIS 27 2.57e-02 6.85e-02 0.3330 -0.169000 0.032700 0.162000 -0.078100 0.221000 1.28e-01 7.69e-01 1.45e-01 4.83e-01 4.71e-02
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 1.85e-01 2.97e-01 0.3330 0.040000 -0.215000 0.077600 0.192000 -0.141000 7.75e-01 1.24e-01 5.80e-01 1.71e-01 3.15e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 2.63e-06 2.27e-05 0.3320 -0.079000 -0.134000 0.072300 0.052400 -0.280000 2.99e-01 7.71e-02 3.41e-01 4.90e-01 2.29e-04
MHC CLASS II ANTIGEN PRESENTATION 100 2.38e-05 1.68e-04 0.3320 0.130000 0.006210 0.062200 0.292000 -0.066400 2.43e-02 9.15e-01 2.83e-01 4.74e-07 2.52e-01
GAB1 SIGNALOSOME 13 1.40e-01 2.43e-01 0.3320 -0.245000 0.080800 0.158000 -0.115000 0.074300 1.26e-01 6.14e-01 3.24e-01 4.73e-01 6.43e-01
DAP12 INTERACTIONS 29 4.14e-01 5.26e-01 0.3320 -0.192000 -0.119000 -0.131000 -0.149000 -0.141000 7.41e-02 2.67e-01 2.21e-01 1.65e-01 1.90e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 18 3.94e-02 9.44e-02 0.3310 0.170000 -0.044300 0.009500 -0.185000 -0.211000 2.11e-01 7.45e-01 9.44e-01 1.74e-01 1.21e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 6.94e-02 1.45e-01 0.3310 -0.121000 -0.187000 -0.133000 0.135000 -0.154000 1.23e-01 1.78e-02 8.99e-02 8.61e-02 4.98e-02
CLEC7A DECTIN 1 SIGNALING 94 6.96e-07 6.70e-06 0.3310 0.116000 0.028400 -0.138000 0.122000 -0.247000 5.13e-02 6.34e-01 2.11e-02 4.12e-02 3.52e-05
CARNITINE METABOLISM 14 1.98e-01 3.11e-01 0.3300 0.172000 -0.116000 0.253000 -0.045900 0.001750 2.65e-01 4.51e-01 1.02e-01 7.66e-01 9.91e-01
DISEASES OF GLYCOSYLATION 121 1.12e-04 6.95e-04 0.3300 0.162000 0.031900 0.213000 0.118000 0.150000 2.17e-03 5.45e-01 5.22e-05 2.52e-02 4.29e-03
METABOLISM OF COFACTORS 18 1.90e-01 3.03e-01 0.3300 0.104000 0.043300 -0.122000 0.094800 -0.269000 4.44e-01 7.51e-01 3.71e-01 4.86e-01 4.84e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 1.58e-01 2.67e-01 0.3290 0.092200 0.136000 0.250000 0.130000 -0.041800 4.98e-01 3.18e-01 6.58e-02 3.40e-01 7.59e-01
SHC1 EVENTS IN ERBB2 SIGNALING 20 1.45e-01 2.49e-01 0.3290 -0.300000 -0.091700 -0.077600 0.060500 -0.017000 2.04e-02 4.78e-01 5.48e-01 6.40e-01 8.95e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 39 3.36e-01 4.58e-01 0.3280 0.168000 0.126000 0.186000 -0.046900 0.162000 6.87e-02 1.74e-01 4.41e-02 6.12e-01 7.98e-02
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 11 2.19e-01 3.35e-01 0.3280 -0.137000 0.244000 0.156000 0.047000 0.051300 4.32e-01 1.62e-01 3.71e-01 7.87e-01 7.68e-01
ASPARAGINE N LINKED GLYCOSYLATION 281 2.95e-18 1.42e-16 0.3270 0.103000 -0.084800 0.054400 0.263000 -0.132000 3.00e-03 1.46e-02 1.18e-01 3.87e-14 1.43e-04
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.46e-06 2.16e-05 0.3270 0.053100 0.306000 -0.086400 -0.048200 -0.028000 4.60e-01 1.95e-05 2.28e-01 5.02e-01 6.97e-01
O LINKED GLYCOSYLATION OF MUCINS 38 7.88e-03 2.66e-02 0.3270 0.076300 -0.162000 0.114000 0.244000 -0.048200 4.16e-01 8.38e-02 2.23e-01 9.15e-03 6.07e-01
MISMATCH REPAIR 14 1.66e-01 2.76e-01 0.3270 0.223000 0.016400 -0.120000 0.026700 -0.206000 1.49e-01 9.15e-01 4.38e-01 8.63e-01 1.83e-01
DISEASES OF MITOTIC CELL CYCLE 37 9.33e-02 1.80e-01 0.3270 -0.010800 -0.231000 -0.099600 0.030000 -0.206000 9.10e-01 1.52e-02 2.95e-01 7.52e-01 2.98e-02
METABOLISM OF FAT SOLUBLE VITAMINS 30 1.34e-01 2.35e-01 0.3260 0.250000 -0.011800 0.126000 0.129000 0.107000 1.79e-02 9.11e-01 2.33e-01 2.23e-01 3.10e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 3.12e-01 4.35e-01 0.3260 0.205000 0.053600 0.144000 0.089500 0.182000 5.61e-02 6.18e-01 1.81e-01 4.05e-01 9.08e-02
INTERLEUKIN RECEPTOR SHC SIGNALING 20 2.68e-01 3.88e-01 0.3260 -0.019300 0.169000 0.068100 -0.024500 0.268000 8.81e-01 1.90e-01 5.98e-01 8.49e-01 3.80e-02
LAGGING STRAND SYNTHESIS 20 4.46e-02 1.04e-01 0.3260 0.164000 0.059700 -0.098700 -0.056200 -0.251000 2.05e-01 6.44e-01 4.45e-01 6.64e-01 5.24e-02
PERK REGULATES GENE EXPRESSION 28 5.81e-02 1.29e-01 0.3260 0.003170 -0.018700 -0.107000 -0.015300 -0.307000 9.77e-01 8.64e-01 3.29e-01 8.89e-01 4.98e-03
SEPARATION OF SISTER CHROMATIDS 162 4.01e-12 9.27e-11 0.3260 0.136000 0.048400 -0.141000 0.148000 -0.209000 2.94e-03 2.88e-01 2.04e-03 1.15e-03 4.69e-06
MUCOPOLYSACCHARIDOSES 11 5.79e-01 6.66e-01 0.3250 0.183000 -0.084600 0.150000 0.131000 0.159000 2.92e-01 6.27e-01 3.88e-01 4.52e-01 3.61e-01
PARASITE INFECTION 54 1.57e-06 1.44e-05 0.3250 -0.271000 -0.068200 0.050900 0.131000 -0.088600 5.66e-04 3.86e-01 5.18e-01 9.66e-02 2.60e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 8.99e-02 1.76e-01 0.3250 -0.077900 -0.177000 -0.090600 0.083900 -0.229000 3.66e-01 3.95e-02 2.93e-01 3.30e-01 7.84e-03
G2 M DNA DAMAGE CHECKPOINT 64 6.07e-02 1.33e-01 0.3240 -0.084000 -0.165000 -0.185000 -0.049200 -0.186000 2.45e-01 2.27e-02 1.07e-02 4.96e-01 1.02e-02
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 3.06e-08 3.84e-07 0.3240 -0.126000 -0.049300 0.142000 0.036000 0.256000 4.53e-02 4.32e-01 2.33e-02 5.67e-01 4.66e-05
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 15 5.21e-01 6.19e-01 0.3240 -0.159000 -0.007490 -0.136000 0.046100 -0.243000 2.88e-01 9.60e-01 3.61e-01 7.57e-01 1.03e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 2.15e-01 3.32e-01 0.3240 -0.145000 -0.092800 -0.141000 -0.207000 -0.113000 1.32e-01 3.35e-01 1.42e-01 3.20e-02 2.43e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 7.92e-01 8.38e-01 0.3230 0.202000 0.122000 0.180000 -0.033500 0.123000 1.75e-01 4.15e-01 2.27e-01 8.22e-01 4.11e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 9.27e-02 1.80e-01 0.3230 -0.185000 0.005920 0.102000 -0.198000 0.141000 1.02e-01 9.58e-01 3.66e-01 7.99e-02 2.13e-01
MRNA SPLICING MINOR PATHWAY 52 5.23e-04 2.64e-03 0.3220 0.206000 0.210000 0.049200 0.004560 -0.121000 1.00e-02 8.89e-03 5.40e-01 9.55e-01 1.31e-01
TRANSLESION SYNTHESIS BY POLH 19 2.00e-01 3.12e-01 0.3220 0.020000 0.021900 -0.184000 -0.054400 -0.257000 8.80e-01 8.69e-01 1.65e-01 6.82e-01 5.25e-02
SIALIC ACID METABOLISM 32 4.43e-02 1.04e-01 0.3220 -0.114000 -0.156000 -0.000598 0.188000 -0.176000 2.64e-01 1.26e-01 9.95e-01 6.59e-02 8.55e-02
GLYCOSAMINOGLYCAN METABOLISM 112 4.04e-06 3.46e-05 0.3220 0.161000 -0.058600 0.127000 0.229000 0.073200 3.32e-03 2.85e-01 2.00e-02 2.81e-05 1.81e-01
SIGNALING BY KIT IN DISEASE 20 4.46e-01 5.60e-01 0.3210 -0.108000 -0.236000 -0.183000 0.000422 -0.049100 4.03e-01 6.80e-02 1.56e-01 9.97e-01 7.04e-01
MRNA SPLICING 188 8.96e-19 4.50e-17 0.3210 0.104000 0.274000 -0.099000 0.021100 -0.082000 1.45e-02 9.13e-11 1.95e-02 6.19e-01 5.29e-02
SHC MEDIATED CASCADE FGFR1 14 3.42e-01 4.64e-01 0.3210 -0.045000 0.093300 -0.153000 -0.029100 -0.261000 7.71e-01 5.45e-01 3.22e-01 8.51e-01 9.13e-02
BILE ACID AND BILE SALT METABOLISM 25 4.51e-02 1.04e-01 0.3210 -0.051500 0.179000 0.010300 0.101000 0.240000 6.56e-01 1.21e-01 9.29e-01 3.81e-01 3.76e-02
NEPHRIN FAMILY INTERACTIONS 22 1.65e-01 2.74e-01 0.3210 -0.045900 0.112000 0.163000 0.090100 0.232000 7.09e-01 3.65e-01 1.86e-01 4.64e-01 6.02e-02
LYSOSOME VESICLE BIOGENESIS 32 1.08e-01 2.00e-01 0.3200 0.080300 0.042700 -0.021100 0.292000 -0.093500 4.32e-01 6.76e-01 8.36e-01 4.27e-03 3.60e-01
PLATELET CALCIUM HOMEOSTASIS 25 7.55e-02 1.55e-01 0.3200 -0.184000 -0.177000 0.058800 -0.129000 0.132000 1.12e-01 1.26e-01 6.11e-01 2.63e-01 2.53e-01
DNA METHYLATION 19 2.93e-02 7.58e-02 0.3200 0.131000 0.016100 0.183000 -0.139000 -0.180000 3.22e-01 9.03e-01 1.68e-01 2.94e-01 1.75e-01
G2 M CHECKPOINTS 130 1.31e-07 1.46e-06 0.3200 0.056800 -0.061200 -0.176000 0.048600 -0.249000 2.64e-01 2.29e-01 5.30e-04 3.40e-01 9.27e-07
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 7.96e-02 1.60e-01 0.3200 -0.199000 -0.152000 -0.154000 -0.055500 -0.114000 3.30e-03 2.53e-02 2.34e-02 4.12e-01 9.10e-02
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.20e-01 6.18e-01 0.3190 -0.267000 -0.074000 -0.153000 -0.039300 0.011800 7.30e-02 6.20e-01 3.06e-01 7.92e-01 9.37e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 12 3.14e-01 4.36e-01 0.3190 -0.056300 0.146000 -0.082700 -0.153000 -0.217000 7.36e-01 3.81e-01 6.20e-01 3.58e-01 1.94e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 4.00e-02 9.49e-02 0.3190 0.172000 0.093600 -0.019800 0.068800 -0.241000 1.37e-01 4.18e-01 8.64e-01 5.52e-01 3.70e-02
RRNA PROCESSING IN THE MITOCHONDRION 10 4.93e-01 5.94e-01 0.3180 0.140000 0.026700 -0.074700 0.054800 -0.268000 4.43e-01 8.84e-01 6.82e-01 7.64e-01 1.42e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 59 1.55e-02 4.63e-02 0.3180 0.013600 0.073200 0.227000 -0.063700 0.200000 8.57e-01 3.31e-01 2.63e-03 3.98e-01 7.85e-03
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 2.15e-02 6.00e-02 0.3180 -0.162000 -0.084600 0.204000 0.064200 0.148000 2.00e-01 5.02e-01 1.06e-01 6.11e-01 2.41e-01
SIGNALING BY PDGFR IN DISEASE 20 3.79e-01 4.99e-01 0.3170 -0.208000 -0.105000 -0.212000 -0.033200 0.011000 1.07e-01 4.16e-01 1.00e-01 7.97e-01 9.32e-01
MITOTIC METAPHASE AND ANAPHASE 202 3.45e-13 1.02e-11 0.3160 0.113000 0.041800 -0.136000 0.167000 -0.198000 5.74e-03 3.07e-01 9.04e-04 4.28e-05 1.25e-06
INHIBITION OF DNA RECOMBINATION AT TELOMERE 34 1.47e-03 6.38e-03 0.3160 0.147000 -0.023200 0.046300 -0.046300 -0.271000 1.37e-01 8.15e-01 6.40e-01 6.40e-01 6.32e-03
ACTIVATION OF BH3 ONLY PROTEINS 28 1.32e-01 2.33e-01 0.3160 -0.122000 -0.176000 -0.039500 0.206000 -0.099300 2.65e-01 1.07e-01 7.17e-01 5.91e-02 3.63e-01
DNA STRAND ELONGATION 32 2.00e-02 5.65e-02 0.3150 0.076200 -0.044900 -0.057600 0.005990 -0.297000 4.56e-01 6.60e-01 5.73e-01 9.53e-01 3.65e-03
SMOOTH MUSCLE CONTRACTION 33 3.15e-02 7.97e-02 0.3150 -0.002090 0.287000 -0.010200 -0.063900 0.113000 9.83e-01 4.34e-03 9.20e-01 5.26e-01 2.63e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 51 9.85e-03 3.22e-02 0.3150 0.179000 -0.042600 0.099400 0.190000 0.138000 2.67e-02 5.98e-01 2.20e-01 1.87e-02 8.93e-02
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 21 4.76e-02 1.09e-01 0.3140 0.190000 -0.002170 0.085800 0.019300 -0.235000 1.32e-01 9.86e-01 4.96e-01 8.78e-01 6.27e-02
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 1.33e-01 2.35e-01 0.3140 0.114000 -0.050700 -0.106000 -0.047700 -0.264000 3.90e-01 7.02e-01 4.24e-01 7.19e-01 4.64e-02
ERBB2 REGULATES CELL MOTILITY 13 4.45e-01 5.59e-01 0.3140 -0.292000 -0.097100 -0.060100 0.010600 0.002850 6.80e-02 5.44e-01 7.08e-01 9.47e-01 9.86e-01
REGULATION OF TNFR1 SIGNALING 34 3.86e-01 5.00e-01 0.3140 0.200000 0.132000 0.112000 0.100000 0.135000 4.35e-02 1.83e-01 2.57e-01 3.13e-01 1.72e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 3.43e-02 8.61e-02 0.3130 0.105000 0.025900 -0.071100 -0.149000 -0.243000 3.83e-01 8.30e-01 5.55e-01 2.17e-01 4.39e-02
HEME BIOSYNTHESIS 13 1.59e-01 2.67e-01 0.3120 -0.009160 -0.132000 0.137000 0.065800 -0.238000 9.54e-01 4.09e-01 3.91e-01 6.81e-01 1.38e-01
C TYPE LECTIN RECEPTORS CLRS 111 2.62e-06 2.27e-05 0.3120 0.065900 0.012600 -0.147000 0.125000 -0.236000 2.31e-01 8.19e-01 7.57e-03 2.33e-02 1.79e-05
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 6.04e-03 2.09e-02 0.3120 -0.056300 -0.126000 -0.102000 -0.219000 -0.140000 4.43e-01 8.71e-02 1.64e-01 2.84e-03 5.60e-02
HOST INTERACTIONS OF HIV FACTORS 123 8.25e-07 7.88e-06 0.3110 0.078300 -0.006650 -0.134000 0.135000 -0.233000 1.34e-01 8.99e-01 1.04e-02 1.00e-02 7.90e-06
INOSITOL PHOSPHATE METABOLISM 46 2.69e-03 1.06e-02 0.3110 -0.048800 0.040200 0.186000 0.129000 0.204000 5.67e-01 6.37e-01 2.92e-02 1.31e-01 1.69e-02
SPHINGOLIPID METABOLISM 79 4.43e-04 2.34e-03 0.3090 0.015000 -0.013100 -0.014300 0.272000 -0.145000 8.18e-01 8.41e-01 8.26e-01 3.03e-05 2.57e-02
SIGNALING BY FGFR2 IIIA TM 19 6.57e-02 1.40e-01 0.3080 0.137000 0.060100 0.005530 -0.063200 -0.262000 3.02e-01 6.50e-01 9.67e-01 6.34e-01 4.79e-02
SIGNALING BY ERBB2 IN CANCER 24 2.77e-01 3.98e-01 0.3080 -0.272000 -0.078800 -0.118000 -0.018400 -0.021400 2.09e-02 5.04e-01 3.18e-01 8.76e-01 8.56e-01
MTORC1 MEDIATED SIGNALLING 24 2.43e-01 3.62e-01 0.3080 -0.007050 0.047100 -0.162000 0.184000 -0.181000 9.52e-01 6.90e-01 1.70e-01 1.19e-01 1.25e-01
G1 S SPECIFIC TRANSCRIPTION 26 2.69e-01 3.89e-01 0.3080 0.082800 -0.072300 -0.084900 0.237000 -0.138000 4.65e-01 5.24e-01 4.54e-01 3.64e-02 2.23e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 5.88e-01 6.74e-01 0.3070 -0.249000 -0.103000 -0.037000 -0.063900 0.128000 1.72e-01 5.72e-01 8.39e-01 7.27e-01 4.85e-01
SHC MEDIATED CASCADE FGFR3 12 3.35e-01 4.57e-01 0.3070 -0.060300 0.209000 -0.186000 0.067800 -0.087200 7.18e-01 2.09e-01 2.65e-01 6.84e-01 6.01e-01
SIGNALING BY ROBO RECEPTORS 205 4.00e-20 2.20e-18 0.3060 0.129000 0.171000 -0.114000 -0.016300 -0.186000 1.46e-03 2.38e-05 4.95e-03 6.87e-01 4.64e-06
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 3.73e-02 9.13e-02 0.3060 -0.216000 -0.093000 -0.113000 -0.117000 -0.109000 1.41e-03 1.70e-01 9.38e-02 8.46e-02 1.08e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 27 1.88e-01 3.00e-01 0.3060 -0.215000 0.000779 -0.028700 -0.196000 0.089000 5.31e-02 9.94e-01 7.97e-01 7.80e-02 4.23e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 3.57e-05 2.41e-04 0.3040 0.060400 -0.011100 -0.160000 0.129000 -0.216000 2.90e-01 8.45e-01 5.12e-03 2.39e-02 1.53e-04
FCERI MEDIATED CA 2 MOBILIZATION 26 8.73e-02 1.72e-01 0.3040 -0.287000 0.000300 -0.101000 0.002290 0.003010 1.13e-02 9.98e-01 3.74e-01 9.84e-01 9.79e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 56 1.31e-03 5.73e-03 0.3040 -0.113000 -0.197000 0.024100 0.178000 -0.094400 1.44e-01 1.09e-02 7.55e-01 2.15e-02 2.22e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 8.05e-01 8.48e-01 0.3040 -0.110000 -0.196000 -0.120000 -0.164000 -0.031600 5.28e-01 2.61e-01 4.92e-01 3.47e-01 8.56e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 72 7.08e-04 3.42e-03 0.3040 -0.023500 0.072600 0.241000 -0.044600 0.163000 7.31e-01 2.87e-01 4.06e-04 5.13e-01 1.70e-02
HIV ELONGATION ARREST AND RECOVERY 32 9.11e-02 1.77e-01 0.3040 0.210000 0.129000 0.131000 -0.122000 0.000874 4.03e-02 2.08e-01 2.00e-01 2.33e-01 9.93e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 1.22e-03 5.38e-03 0.3030 0.118000 -0.059800 -0.035300 0.060800 -0.264000 1.37e-01 4.52e-01 6.57e-01 4.44e-01 9.01e-04
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 4.69e-01 5.75e-01 0.3030 -0.059900 -0.200000 -0.117000 0.175000 -0.063400 6.51e-01 1.32e-01 3.76e-01 1.86e-01 6.33e-01
EXTRACELLULAR MATRIX ORGANIZATION 234 6.11e-06 5.08e-05 0.3030 0.080200 0.162000 0.186000 -0.035000 0.153000 3.49e-02 1.99e-05 1.05e-06 3.57e-01 5.61e-05
DISEASES OF METABOLISM 193 6.57e-05 4.20e-04 0.3030 0.192000 0.078000 0.168000 0.096500 0.105000 4.26e-06 6.21e-02 5.98e-05 2.10e-02 1.21e-02
CA2 PATHWAY 56 6.20e-03 2.14e-02 0.3020 -0.226000 -0.142000 -0.132000 0.038900 0.038400 3.50e-03 6.64e-02 8.80e-02 6.14e-01 6.19e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 23 4.63e-01 5.71e-01 0.3020 -0.195000 -0.140000 -0.130000 -0.126000 0.024900 1.05e-01 2.45e-01 2.80e-01 2.94e-01 8.36e-01
CONDENSATION OF PROPHASE CHROMOSOMES 26 1.04e-01 1.96e-01 0.3010 -0.031600 -0.028400 -0.072900 -0.111000 -0.267000 7.81e-01 8.02e-01 5.20e-01 3.27e-01 1.84e-02
SIGNALING BY FGFR2 IN DISEASE 35 3.60e-02 8.95e-02 0.3010 -0.033800 0.022300 -0.119000 -0.140000 -0.236000 7.29e-01 8.20e-01 2.24e-01 1.53e-01 1.58e-02
FC EPSILON RECEPTOR FCERI SIGNALING 123 4.46e-05 2.94e-04 0.3010 0.008280 -0.019000 -0.162000 0.162000 -0.194000 8.74e-01 7.16e-01 1.93e-03 1.92e-03 1.98e-04
RHOA GTPASE CYCLE 140 1.59e-06 1.45e-05 0.3010 -0.017400 0.183000 0.125000 0.039400 0.199000 7.23e-01 1.92e-04 1.06e-02 4.21e-01 4.83e-05
NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 1.21e-01 2.17e-01 0.3010 0.055800 0.190000 0.142000 -0.097000 0.147000 4.74e-01 1.48e-02 6.90e-02 2.14e-01 6.00e-02
G ALPHA Z SIGNALLING EVENTS 43 2.46e-02 6.67e-02 0.3000 -0.072000 -0.048200 -0.029400 0.263000 -0.112000 4.14e-01 5.84e-01 7.39e-01 2.82e-03 2.03e-01
RNA POLYMERASE I PROMOTER ESCAPE 46 4.64e-04 2.41e-03 0.3000 0.058500 0.033600 -0.027200 -0.095800 -0.275000 4.92e-01 6.94e-01 7.50e-01 2.61e-01 1.25e-03
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 23 7.25e-02 1.50e-01 0.3000 0.037100 -0.024100 -0.035800 -0.113000 -0.272000 7.58e-01 8.42e-01 7.67e-01 3.48e-01 2.38e-02
COSTIMULATION BY THE CD28 FAMILY 49 2.17e-01 3.33e-01 0.3000 -0.111000 -0.147000 -0.126000 0.106000 -0.171000 1.80e-01 7.54e-02 1.28e-01 1.99e-01 3.87e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 4.49e-01 5.63e-01 0.3000 -0.115000 -0.006120 -0.063500 0.141000 -0.230000 4.41e-01 9.67e-01 6.70e-01 3.45e-01 1.23e-01
G0 AND EARLY G1 24 3.68e-01 4.88e-01 0.3000 0.014800 -0.020900 -0.101000 0.227000 -0.166000 9.00e-01 8.60e-01 3.92e-01 5.40e-02 1.60e-01
HEDGEHOG ON STATE 82 4.72e-04 2.44e-03 0.2980 0.201000 0.134000 0.000496 0.155000 -0.081900 1.69e-03 3.54e-02 9.94e-01 1.54e-02 2.00e-01
REGULATION OF KIT SIGNALING 16 2.66e-01 3.87e-01 0.2980 -0.057600 -0.229000 -0.029000 0.166000 0.070500 6.90e-01 1.14e-01 8.41e-01 2.50e-01 6.26e-01
TCR SIGNALING 99 1.63e-05 1.22e-04 0.2980 0.085200 0.039900 -0.144000 0.135000 -0.203000 1.43e-01 4.93e-01 1.37e-02 2.01e-02 4.96e-04
INTERLEUKIN 1 SIGNALING 95 2.29e-06 2.02e-05 0.2980 0.180000 0.060400 -0.084500 0.115000 -0.179000 2.47e-03 3.09e-01 1.55e-01 5.24e-02 2.52e-03
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.15e-01 2.10e-01 0.2970 -0.136000 0.032900 0.125000 -0.020900 0.230000 2.59e-01 7.85e-01 3.00e-01 8.62e-01 5.66e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 6.77e-01 7.46e-01 0.2970 -0.105000 -0.023000 0.059700 -0.240000 0.124000 5.14e-01 8.86e-01 7.10e-01 1.34e-01 4.38e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 3.10e-01 4.33e-01 0.2960 0.156000 0.219000 0.073800 -0.058700 0.080800 1.40e-01 3.76e-02 4.84e-01 5.78e-01 4.44e-01
SIGNALING BY FGFR1 IN DISEASE 32 7.67e-02 1.56e-01 0.2960 -0.229000 0.007200 -0.184000 -0.023700 0.025900 2.48e-02 9.44e-01 7.22e-02 8.16e-01 8.00e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 7.86e-02 1.58e-01 0.2960 0.042900 0.057900 -0.081400 -0.042800 -0.272000 7.16e-01 6.23e-01 4.90e-01 7.17e-01 2.12e-02
ASSEMBLY OF THE HIV VIRION 16 5.21e-01 6.19e-01 0.2950 0.178000 0.094000 0.123000 0.150000 -0.094600 2.19e-01 5.15e-01 3.93e-01 2.97e-01 5.12e-01
RHO GTPASES ACTIVATE CIT 18 4.55e-01 5.66e-01 0.2950 -0.012500 0.246000 0.077300 -0.103000 0.100000 9.27e-01 7.11e-02 5.70e-01 4.51e-01 4.61e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 3.90e-02 9.37e-02 0.2950 0.123000 0.091600 -0.046000 -0.090800 -0.230000 2.95e-01 4.37e-01 6.97e-01 4.41e-01 5.09e-02
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 2.05e-01 3.19e-01 0.2940 0.177000 0.129000 -0.011500 -0.090500 -0.174000 2.35e-01 3.87e-01 9.39e-01 5.44e-01 2.44e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 1.59e-01 2.67e-01 0.2940 -0.165000 0.045000 -0.136000 -0.072000 0.182000 2.25e-01 7.41e-01 3.16e-01 5.97e-01 1.82e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 4.44e-02 1.04e-01 0.2930 -0.185000 -0.053200 0.124000 0.147000 0.109000 1.53e-01 6.80e-01 3.38e-01 2.54e-01 3.97e-01
ERK MAPK TARGETS 22 7.35e-02 1.52e-01 0.2930 -0.136000 -0.147000 0.072300 0.016400 -0.201000 2.70e-01 2.33e-01 5.57e-01 8.94e-01 1.03e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 86 4.62e-03 1.68e-02 0.2930 0.142000 0.117000 0.050600 0.221000 -0.016400 2.30e-02 6.02e-02 4.17e-01 3.93e-04 7.93e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 5.56e-01 6.47e-01 0.2930 -0.132000 0.147000 0.114000 -0.086400 0.161000 4.29e-01 3.77e-01 4.93e-01 6.04e-01 3.33e-01
SIGNALING BY NODAL 14 3.83e-01 5.00e-01 0.2920 -0.109000 0.047800 0.129000 -0.232000 -0.019400 4.81e-01 7.57e-01 4.04e-01 1.32e-01 9.00e-01
RHOBTB GTPASE CYCLE 35 2.01e-02 5.67e-02 0.2910 -0.106000 0.124000 -0.209000 0.102000 -0.064000 2.78e-01 2.05e-01 3.27e-02 2.99e-01 5.12e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 104 9.55e-03 3.14e-02 0.2910 0.060100 0.130000 0.200000 -0.042100 0.150000 2.90e-01 2.24e-02 4.43e-04 4.59e-01 8.43e-03
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 2.92e-01 4.16e-01 0.2900 0.057400 -0.006080 -0.163000 0.087800 -0.216000 6.34e-01 9.60e-01 1.76e-01 4.66e-01 7.30e-02
ACYL CHAIN REMODELLING OF PE 16 3.67e-01 4.87e-01 0.2900 -0.121000 -0.132000 -0.004730 0.226000 -0.028500 4.02e-01 3.60e-01 9.74e-01 1.17e-01 8.44e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 2.87e-02 7.51e-02 0.2900 -0.160000 0.072300 0.160000 0.116000 0.118000 1.83e-01 5.49e-01 1.84e-01 3.37e-01 3.27e-01
REGULATED NECROSIS 45 4.88e-02 1.12e-01 0.2890 0.008800 -0.018800 -0.162000 0.014500 -0.238000 9.19e-01 8.28e-01 6.02e-02 8.67e-01 5.69e-03
SIGNALING BY NTRK3 TRKC 17 5.47e-01 6.41e-01 0.2890 -0.010200 0.123000 0.070600 -0.050900 0.247000 9.42e-01 3.80e-01 6.14e-01 7.16e-01 7.84e-02
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 2.98e-02 7.65e-02 0.2890 0.096600 0.017400 -0.089600 -0.005620 -0.257000 3.37e-01 8.63e-01 3.73e-01 9.55e-01 1.08e-02
POLO LIKE KINASE MEDIATED EVENTS 13 4.63e-01 5.71e-01 0.2880 0.107000 0.234000 -0.021900 0.068500 -0.109000 5.03e-01 1.45e-01 8.91e-01 6.69e-01 4.97e-01
INTERLEUKIN 6 FAMILY SIGNALING 18 7.12e-01 7.73e-01 0.2880 0.067500 0.124000 0.196000 0.075900 0.139000 6.20e-01 3.64e-01 1.51e-01 5.77e-01 3.09e-01
SYNTHESIS OF PC 24 3.08e-01 4.31e-01 0.2880 0.048500 0.066700 0.055300 0.268000 0.034300 6.81e-01 5.72e-01 6.39e-01 2.30e-02 7.71e-01
SHC1 EVENTS IN ERBB4 SIGNALING 12 8.55e-01 8.90e-01 0.2880 -0.175000 -0.103000 -0.142000 0.099700 -0.108000 2.94e-01 5.36e-01 3.93e-01 5.50e-01 5.19e-01
FRS MEDIATED FGFR2 SIGNALING 17 4.85e-01 5.87e-01 0.2870 -0.068400 0.053600 -0.191000 -0.041400 -0.191000 6.26e-01 7.02e-01 1.72e-01 7.67e-01 1.72e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 1.69e-01 2.79e-01 0.2870 -0.143000 0.121000 0.064700 0.125000 0.165000 3.07e-01 3.88e-01 6.44e-01 3.72e-01 2.38e-01
METABOLISM OF CARBOHYDRATES 254 6.44e-10 1.05e-08 0.2870 0.153000 -0.013300 0.109000 0.216000 0.014100 2.86e-05 7.16e-01 2.92e-03 3.25e-09 6.99e-01
INFLAMMASOMES 18 1.53e-01 2.61e-01 0.2860 0.112000 -0.048200 -0.144000 -0.151000 -0.154000 4.12e-01 7.23e-01 2.89e-01 2.68e-01 2.59e-01
THE PHOTOTRANSDUCTION CASCADE 19 3.85e-01 5.00e-01 0.2860 -0.145000 -0.026500 -0.244000 0.016800 -0.021700 2.74e-01 8.41e-01 6.58e-02 8.99e-01 8.70e-01
RAC1 GTPASE CYCLE 175 2.33e-12 5.74e-11 0.2860 -0.134000 0.113000 0.136000 -0.012600 0.180000 2.19e-03 1.03e-02 1.90e-03 7.75e-01 4.22e-05
POTASSIUM CHANNELS 88 1.06e-07 1.18e-06 0.2860 -0.251000 -0.098200 0.052900 0.039600 0.067300 4.64e-05 1.12e-01 3.91e-01 5.21e-01 2.75e-01
METABOLISM OF NUCLEOTIDES 91 9.42e-04 4.34e-03 0.2860 0.107000 -0.078600 -0.054200 0.198000 -0.147000 7.84e-02 1.95e-01 3.72e-01 1.08e-03 1.51e-02
GAP JUNCTION DEGRADATION 11 6.14e-01 6.98e-01 0.2860 0.007010 0.107000 0.078800 0.247000 -0.053300 9.68e-01 5.39e-01 6.51e-01 1.56e-01 7.59e-01
SIGNALING BY NOTCH4 83 2.50e-05 1.73e-04 0.2850 0.157000 0.038700 -0.065500 0.075700 -0.213000 1.38e-02 5.42e-01 3.02e-01 2.33e-01 7.97e-04
REGULATION OF BETA CELL DEVELOPMENT 23 2.62e-02 6.93e-02 0.2850 -0.134000 -0.073600 0.219000 -0.099000 0.000947 2.68e-01 5.42e-01 6.85e-02 4.11e-01 9.94e-01
TRIGLYCERIDE METABOLISM 22 4.61e-01 5.71e-01 0.2850 -0.069700 -0.043500 -0.086900 0.128000 -0.225000 5.72e-01 7.24e-01 4.81e-01 2.99e-01 6.83e-02
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 116 6.29e-05 4.06e-04 0.2840 0.034800 0.049100 0.192000 0.124000 0.158000 5.17e-01 3.62e-01 3.55e-04 2.17e-02 3.32e-03
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 5.71e-01 6.61e-01 0.2840 0.067100 0.116000 0.167000 0.006930 0.187000 5.25e-01 2.73e-01 1.14e-01 9.48e-01 7.61e-02
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.68e-01 3.88e-01 0.2840 -0.221000 -0.118000 -0.091300 -0.096900 -0.005990 1.99e-02 2.15e-01 3.37e-01 3.08e-01 9.50e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 1.62e-02 4.81e-02 0.2840 0.108000 0.144000 -0.054800 -0.135000 -0.164000 2.97e-01 1.67e-01 5.97e-01 1.93e-01 1.13e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 4.49e-02 1.04e-01 0.2840 0.116000 0.061000 -0.104000 0.027900 -0.227000 2.63e-01 5.57e-01 3.18e-01 7.88e-01 2.85e-02
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 14 8.43e-01 8.78e-01 0.2830 0.156000 0.155000 0.172000 -0.004390 0.048100 3.12e-01 3.14e-01 2.66e-01 9.77e-01 7.55e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 11 5.18e-01 6.17e-01 0.2820 -0.077400 0.178000 -0.156000 -0.132000 0.017900 6.57e-01 3.07e-01 3.72e-01 4.49e-01 9.18e-01
METABOLISM OF FOLATE AND PTERINES 15 8.90e-01 9.13e-01 0.2820 0.160000 0.101000 0.158000 0.099600 0.093400 2.84e-01 4.99e-01 2.88e-01 5.04e-01 5.31e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 11 5.34e-01 6.29e-01 0.2820 -0.062300 0.024800 -0.037300 -0.069100 -0.262000 7.21e-01 8.87e-01 8.31e-01 6.92e-01 1.32e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 2.21e-01 3.36e-01 0.2820 -0.116000 -0.178000 0.131000 0.040200 -0.125000 4.54e-01 2.49e-01 3.97e-01 7.95e-01 4.20e-01
G ALPHA 12 13 SIGNALLING EVENTS 74 1.22e-03 5.39e-03 0.2810 -0.034200 0.068000 0.212000 0.009740 0.168000 6.11e-01 3.12e-01 1.64e-03 8.85e-01 1.23e-02
FGFR1 MUTANT RECEPTOR ACTIVATION 25 1.22e-01 2.18e-01 0.2810 -0.198000 0.071900 -0.174000 -0.041100 0.053900 8.72e-02 5.34e-01 1.33e-01 7.22e-01 6.41e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.43e-01 2.47e-01 0.2810 -0.066300 0.132000 0.138000 -0.122000 0.152000 4.85e-01 1.65e-01 1.47e-01 1.98e-01 1.09e-01
METABOLISM OF PORPHYRINS 19 7.15e-02 1.49e-01 0.2810 -0.019500 -0.079900 0.121000 0.035600 -0.237000 8.83e-01 5.47e-01 3.61e-01 7.88e-01 7.38e-02
MEIOTIC RECOMBINATION 36 4.90e-01 5.91e-01 0.2800 -0.115000 -0.132000 -0.118000 -0.095900 -0.158000 2.33e-01 1.71e-01 2.21e-01 3.19e-01 1.01e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 6.58e-01 7.31e-01 0.2800 -0.213000 -0.053400 -0.018200 -0.172000 -0.018100 1.53e-01 7.21e-01 9.03e-01 2.50e-01 9.03e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 105 9.79e-04 4.42e-03 0.2800 0.087900 0.029200 0.141000 0.192000 0.113000 1.20e-01 6.05e-01 1.28e-02 6.63e-04 4.54e-02
CELL CYCLE CHECKPOINTS 236 2.23e-09 3.38e-08 0.2800 0.024300 -0.044400 -0.175000 0.070800 -0.200000 5.21e-01 2.41e-01 3.89e-06 6.16e-02 1.25e-07
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 2.65e-01 3.87e-01 0.2790 -0.017000 0.208000 0.082800 -0.112000 0.122000 8.70e-01 4.50e-02 4.25e-01 2.81e-01 2.41e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 26 3.55e-01 4.78e-01 0.2790 0.033500 -0.024400 -0.026400 0.253000 -0.106000 7.68e-01 8.29e-01 8.16e-01 2.56e-02 3.47e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 6.33e-04 3.09e-03 0.2790 0.047600 -0.123000 0.028300 0.144000 -0.197000 4.73e-01 6.46e-02 6.70e-01 2.98e-02 3.01e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 1.77e-01 2.88e-01 0.2790 -0.118000 -0.149000 0.114000 0.115000 0.124000 3.99e-01 2.89e-01 4.14e-01 4.11e-01 3.77e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 12 4.62e-01 5.71e-01 0.2790 -0.037400 0.206000 0.166000 0.077400 0.021800 8.23e-01 2.18e-01 3.20e-01 6.43e-01 8.96e-01
PYRIMIDINE CATABOLISM 10 6.31e-01 7.12e-01 0.2780 0.030200 -0.272000 -0.003380 -0.027700 -0.044900 8.68e-01 1.37e-01 9.85e-01 8.79e-01 8.06e-01
HS GAG BIOSYNTHESIS 29 1.09e-01 2.00e-01 0.2780 0.200000 -0.053900 -0.011100 0.179000 0.047600 6.25e-02 6.16e-01 9.18e-01 9.59e-02 6.57e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 1.04e-01 1.96e-01 0.2780 -0.124000 0.058000 0.099300 0.212000 -0.059000 3.62e-01 6.70e-01 4.66e-01 1.19e-01 6.65e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 148 9.43e-11 1.73e-09 0.2780 0.138000 0.097300 -0.074900 0.019000 -0.206000 3.81e-03 4.12e-02 1.16e-01 6.90e-01 1.50e-05
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 2.80e-01 4.00e-01 0.2770 0.064300 0.043200 0.000499 0.240000 -0.116000 5.56e-01 6.93e-01 9.96e-01 2.80e-02 2.88e-01
CYTOPROTECTION BY HMOX1 118 2.02e-08 2.69e-07 0.2770 0.135000 0.102000 -0.074700 0.017600 -0.205000 1.14e-02 5.69e-02 1.61e-01 7.42e-01 1.20e-04
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 41 6.92e-02 1.45e-01 0.2750 -0.081000 0.056900 -0.129000 -0.209000 -0.076500 3.70e-01 5.28e-01 1.53e-01 2.08e-02 3.97e-01
HIV INFECTION 219 3.50e-10 5.87e-09 0.2750 0.064100 0.005890 -0.117000 0.102000 -0.218000 1.03e-01 8.81e-01 2.85e-03 9.14e-03 2.85e-08
PROCESSING OF INTRONLESS PRE MRNAS 19 1.94e-01 3.07e-01 0.2750 -0.135000 0.196000 -0.132000 -0.031700 -0.022700 3.08e-01 1.39e-01 3.19e-01 8.11e-01 8.64e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 24 3.25e-01 4.46e-01 0.2750 -0.185000 0.066000 -0.167000 -0.058900 -0.075600 1.17e-01 5.76e-01 1.58e-01 6.17e-01 5.22e-01
FRS MEDIATED FGFR4 SIGNALING 12 5.42e-01 6.37e-01 0.2750 -0.041300 0.025800 -0.245000 0.104000 -0.046700 8.04e-01 8.77e-01 1.42e-01 5.31e-01 7.79e-01
STRIATED MUSCLE CONTRACTION 23 3.55e-01 4.78e-01 0.2740 0.001350 0.140000 0.084500 -0.219000 0.027100 9.91e-01 2.46e-01 4.83e-01 6.93e-02 8.22e-01
NEDDYLATION 214 3.64e-08 4.53e-07 0.2740 0.075300 -0.103000 -0.060300 0.162000 -0.170000 5.80e-02 9.82e-03 1.29e-01 4.60e-05 1.93e-05
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 2.41e-03 9.67e-03 0.2740 0.071300 -0.096600 0.052800 0.146000 -0.191000 3.32e-01 1.88e-01 4.73e-01 4.69e-02 9.51e-03
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 3.34e-01 4.56e-01 0.2730 -0.067900 -0.128000 0.221000 -0.017900 -0.065300 7.10e-01 4.84e-01 2.25e-01 9.22e-01 7.21e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 7.92e-01 8.38e-01 0.2730 0.071100 0.006610 0.116000 0.232000 0.046800 6.83e-01 9.70e-01 5.07e-01 1.84e-01 7.88e-01
UCH PROTEINASES 88 8.26e-06 6.71e-05 0.2720 0.190000 0.065500 -0.024500 0.034500 -0.179000 2.12e-03 2.89e-01 6.91e-01 5.76e-01 3.66e-03
FGFR2 ALTERNATIVE SPLICING 25 1.98e-01 3.11e-01 0.2720 0.165000 0.202000 0.027500 -0.014500 -0.071900 1.53e-01 8.07e-02 8.12e-01 9.00e-01 5.34e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 2.15e-01 3.32e-01 0.2720 -0.204000 -0.141000 -0.063000 -0.088600 -0.015000 2.04e-02 1.09e-01 4.75e-01 3.15e-01 8.65e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 5.99e-01 6.82e-01 0.2720 -0.025500 0.053400 -0.080800 0.237000 -0.086100 8.64e-01 7.20e-01 5.88e-01 1.11e-01 5.64e-01
METABOLISM OF STEROID HORMONES 19 1.32e-01 2.33e-01 0.2710 0.228000 0.010300 -0.066100 -0.027800 -0.128000 8.55e-02 9.38e-01 6.18e-01 8.34e-01 3.33e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 1.79e-01 2.90e-01 0.2710 0.012700 -0.072700 -0.041300 0.257000 0.022100 9.06e-01 4.98e-01 7.00e-01 1.67e-02 8.37e-01
MAPK6 MAPK4 SIGNALING 83 2.16e-04 1.22e-03 0.2710 0.112000 0.049500 -0.098900 0.087400 -0.203000 7.86e-02 4.36e-01 1.19e-01 1.69e-01 1.42e-03
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.05e-02 1.76e-01 0.2710 0.066900 -0.007120 0.005580 -0.106000 -0.240000 5.79e-01 9.53e-01 9.63e-01 3.79e-01 4.63e-02
CARDIAC CONDUCTION 102 5.44e-07 5.38e-06 0.2710 -0.206000 -0.057100 0.107000 -0.098500 0.079000 3.24e-04 3.20e-01 6.13e-02 8.58e-02 1.68e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 21 5.25e-01 6.21e-01 0.2690 0.030000 -0.009270 -0.102000 0.228000 -0.096400 8.12e-01 9.41e-01 4.20e-01 7.08e-02 4.44e-01
TRAFFICKING OF AMPA RECEPTORS 31 2.92e-02 7.58e-02 0.2690 -0.147000 0.012100 0.117000 0.060900 0.182000 1.56e-01 9.07e-01 2.58e-01 5.57e-01 7.96e-02
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 3.10e-02 7.87e-02 0.2690 0.050000 -0.032800 -0.014400 0.239000 -0.107000 4.92e-01 6.53e-01 8.44e-01 1.06e-03 1.41e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 6.81e-01 7.49e-01 0.2680 -0.142000 -0.142000 -0.087800 0.008800 -0.154000 2.09e-01 2.10e-01 4.38e-01 9.38e-01 1.73e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 2.43e-01 3.62e-01 0.2680 -0.111000 -0.004990 -0.112000 0.212000 -0.045900 3.27e-01 9.65e-01 3.21e-01 6.16e-02 6.86e-01
GLUCAGON TYPE LIGAND RECEPTORS 23 5.53e-01 6.45e-01 0.2680 0.015300 -0.061700 -0.120000 0.093500 -0.211000 8.99e-01 6.08e-01 3.21e-01 4.38e-01 7.92e-02
TBC RABGAPS 43 2.17e-02 6.04e-02 0.2680 0.105000 -0.032300 0.154000 0.160000 -0.102000 2.36e-01 7.14e-01 8.12e-02 6.91e-02 2.49e-01
SARS COV 2 INFECTION 65 2.21e-02 6.13e-02 0.2670 0.065700 -0.045900 -0.019200 0.191000 -0.167000 3.60e-01 5.22e-01 7.89e-01 7.72e-03 2.01e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 92 2.55e-04 1.42e-03 0.2670 0.136000 0.053300 -0.096600 0.146000 -0.139000 2.44e-02 3.78e-01 1.10e-01 1.57e-02 2.17e-02
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 46 4.03e-03 1.51e-02 0.2670 0.052400 0.058200 0.026300 -0.208000 -0.145000 5.39e-01 4.95e-01 7.58e-01 1.49e-02 8.81e-02
MRNA CAPPING 29 8.28e-02 1.64e-01 0.2660 0.069500 0.009220 -0.030300 0.008200 -0.255000 5.17e-01 9.32e-01 7.77e-01 9.39e-01 1.75e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 7.65e-01 8.19e-01 0.2660 0.024300 -0.151000 -0.132000 0.107000 -0.137000 8.71e-01 3.13e-01 3.76e-01 4.75e-01 3.60e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 6.21e-01 7.03e-01 0.2650 -0.094500 -0.042000 0.145000 -0.102000 0.168000 5.55e-01 7.93e-01 3.65e-01 5.22e-01 2.94e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 6.33e-01 7.12e-01 0.2650 -0.069300 -0.094900 -0.149000 0.125000 -0.138000 5.26e-01 3.85e-01 1.73e-01 2.54e-01 2.07e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 1.67e-01 2.77e-01 0.2650 0.037700 -0.035600 0.222000 0.114000 0.074500 7.39e-01 7.54e-01 5.03e-02 3.16e-01 5.11e-01
INWARDLY RECTIFYING K CHANNELS 31 3.82e-01 4.99e-01 0.2640 -0.162000 -0.093300 -0.082600 0.106000 -0.128000 1.19e-01 3.69e-01 4.26e-01 3.05e-01 2.17e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 183 1.54e-06 1.43e-05 0.2640 0.090700 -0.024200 0.052600 0.241000 0.000994 3.47e-02 5.73e-01 2.20e-01 2.06e-08 9.82e-01
SYNDECAN INTERACTIONS 26 3.28e-01 4.50e-01 0.2630 0.063000 0.245000 0.013800 0.025200 0.067800 5.79e-01 3.09e-02 9.03e-01 8.24e-01 5.49e-01
CILIUM ASSEMBLY 189 5.24e-07 5.22e-06 0.2630 0.155000 0.119000 -0.003310 0.157000 0.080100 2.51e-04 4.77e-03 9.38e-01 2.02e-04 5.80e-02
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.93e-16 8.92e-15 0.2630 0.064600 0.224000 -0.096900 0.006260 -0.074900 8.74e-02 3.22e-09 1.04e-02 8.68e-01 4.76e-02
INTEGRIN CELL SURFACE INTERACTIONS 68 9.88e-03 3.22e-02 0.2620 -0.025200 0.143000 0.067600 -0.206000 0.029800 7.19e-01 4.14e-02 3.35e-01 3.39e-03 6.71e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 20 1.81e-01 2.92e-01 0.2620 0.028900 -0.087200 0.052000 -0.150000 -0.187000 8.23e-01 5.00e-01 6.88e-01 2.44e-01 1.47e-01
PLATELET AGGREGATION PLUG FORMATION 31 3.16e-01 4.38e-01 0.2620 0.036600 0.107000 0.204000 0.067700 0.099500 7.24e-01 3.03e-01 4.99e-02 5.14e-01 3.38e-01
INTEGRATION OF ENERGY METABOLISM 96 3.79e-04 2.06e-03 0.2620 0.019400 0.028200 0.102000 0.210000 0.114000 7.43e-01 6.33e-01 8.41e-02 3.86e-04 5.31e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 2.56e-01 3.77e-01 0.2620 0.032600 0.108000 -0.081400 0.132000 -0.178000 7.78e-01 3.48e-01 4.81e-01 2.54e-01 1.24e-01
INTEGRIN SIGNALING 24 3.82e-01 4.99e-01 0.2620 -0.012700 0.099700 0.188000 0.057600 0.141000 9.14e-01 3.98e-01 1.11e-01 6.25e-01 2.33e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 2.90e-02 7.53e-02 0.2610 -0.125000 0.034200 0.038000 0.157000 0.158000 2.22e-01 7.38e-01 7.10e-01 1.25e-01 1.21e-01
DNA DAMAGE RECOGNITION IN GG NER 38 3.78e-02 9.17e-02 0.2610 0.140000 0.006260 0.084900 0.095900 -0.178000 1.35e-01 9.47e-01 3.65e-01 3.07e-01 5.72e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 7.39e-01 7.97e-01 0.2590 0.034100 0.099600 -0.125000 0.062800 -0.191000 8.52e-01 5.85e-01 4.95e-01 7.31e-01 2.95e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 1.19e-01 2.15e-01 0.2590 0.198000 0.140000 0.004030 -0.043300 -0.079800 7.00e-02 2.01e-01 9.71e-01 6.92e-01 4.65e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 1.06e-01 1.97e-01 0.2580 -0.092000 0.036500 -0.010800 0.233000 0.047200 4.00e-01 7.38e-01 9.22e-01 3.27e-02 6.65e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.72e-01 4.92e-01 0.2580 -0.114000 -0.000711 0.120000 -0.137000 0.142000 3.44e-01 9.95e-01 3.18e-01 2.55e-01 2.39e-01
SEMAPHORIN INTERACTIONS 64 1.69e-01 2.79e-01 0.2570 0.026300 0.088300 0.132000 -0.089200 0.179000 7.16e-01 2.22e-01 6.70e-02 2.18e-01 1.31e-02
P75 NTR RECEPTOR MEDIATED SIGNALLING 93 1.57e-04 9.19e-04 0.2570 -0.032400 0.061200 0.219000 -0.007350 0.115000 5.89e-01 3.08e-01 2.57e-04 9.03e-01 5.65e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 8.35e-01 8.74e-01 0.2570 -0.075100 -0.075800 -0.150000 0.098000 -0.150000 5.71e-01 5.68e-01 2.57e-01 4.60e-01 2.58e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 2.90e-01 4.13e-01 0.2570 -0.041000 0.071100 0.051400 -0.113000 0.209000 6.88e-01 4.87e-01 6.15e-01 2.69e-01 4.04e-02
CD28 DEPENDENT PI3K AKT SIGNALING 20 2.99e-01 4.22e-01 0.2570 0.019200 -0.201000 0.020500 0.148000 0.051800 8.82e-01 1.20e-01 8.74e-01 2.51e-01 6.88e-01
OPIOID SIGNALLING 85 2.01e-04 1.15e-03 0.2560 -0.185000 -0.074300 -0.057500 0.150000 0.006460 3.15e-03 2.36e-01 3.60e-01 1.69e-02 9.18e-01
PRE NOTCH EXPRESSION AND PROCESSING 62 1.75e-02 5.11e-02 0.2560 -0.025700 0.001520 0.194000 -0.088300 0.139000 7.26e-01 9.83e-01 8.16e-03 2.30e-01 5.85e-02
METABOLISM OF RNA 642 5.72e-44 3.30e-41 0.2560 0.113000 0.155000 -0.091700 -0.005110 -0.142000 1.31e-06 2.38e-11 8.05e-05 8.26e-01 9.11e-10
FATTY ACID METABOLISM 143 1.40e-05 1.07e-04 0.2560 0.061800 0.036000 -0.037800 0.163000 -0.180000 2.02e-01 4.58e-01 4.36e-01 7.75e-04 2.07e-04
NEGATIVE REGULATION OF FLT3 14 9.06e-01 9.25e-01 0.2550 0.078400 0.109000 0.133000 -0.119000 0.124000 6.12e-01 4.81e-01 3.88e-01 4.40e-01 4.23e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 5.73e-01 6.61e-01 0.2550 0.013400 0.017200 -0.127000 0.132000 -0.177000 9.15e-01 8.91e-01 3.15e-01 2.96e-01 1.60e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 62 6.25e-04 3.07e-03 0.2550 0.195000 -0.027800 0.090600 -0.017300 -0.134000 7.91e-03 7.05e-01 2.18e-01 8.14e-01 6.89e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 2.60e-01 3.81e-01 0.2550 0.025900 0.044400 0.226000 0.072900 0.077500 8.19e-01 6.95e-01 4.59e-02 5.20e-01 4.94e-01
SARS COV 1 INFECTION 48 4.61e-02 1.06e-01 0.2550 0.068000 0.060500 -0.019600 0.150000 -0.184000 4.15e-01 4.69e-01 8.15e-01 7.23e-02 2.73e-02
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 21 4.66e-01 5.73e-01 0.2550 0.002860 -0.118000 -0.112000 -0.158000 -0.116000 9.82e-01 3.48e-01 3.74e-01 2.10e-01 3.56e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 3.32e-01 4.54e-01 0.2540 0.038600 0.007700 -0.140000 0.013300 -0.208000 7.39e-01 9.47e-01 2.26e-01 9.09e-01 7.13e-02
MET PROMOTES CELL MOTILITY 38 2.70e-01 3.89e-01 0.2540 -0.027500 0.148000 0.082600 -0.054000 0.180000 7.69e-01 1.15e-01 3.78e-01 5.65e-01 5.49e-02
EPHB MEDIATED FORWARD SIGNALING 42 3.08e-02 7.85e-02 0.2540 -0.108000 -0.115000 0.039800 0.152000 -0.121000 2.27e-01 1.97e-01 6.56e-01 8.78e-02 1.74e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 69 1.09e-01 2.00e-01 0.2540 -0.044500 -0.129000 -0.135000 -0.080100 -0.145000 5.23e-01 6.36e-02 5.20e-02 2.50e-01 3.77e-02
DUAL INCISION IN TC NER 64 1.40e-03 6.10e-03 0.2540 0.048200 -0.011100 -0.047900 -0.082600 -0.230000 5.05e-01 8.77e-01 5.08e-01 2.53e-01 1.48e-03
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 8.93e-01 9.14e-01 0.2540 -0.083900 -0.185000 -0.103000 0.105000 -0.037200 6.46e-01 3.10e-01 5.73e-01 5.67e-01 8.39e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 5.97e-02 1.32e-01 0.2530 0.165000 0.089900 0.080000 -0.009520 -0.150000 1.02e-01 3.72e-01 4.27e-01 9.25e-01 1.37e-01
CD209 DC SIGN SIGNALING 18 7.08e-01 7.70e-01 0.2530 -0.159000 -0.075200 -0.083000 0.105000 -0.124000 2.43e-01 5.81e-01 5.42e-01 4.41e-01 3.64e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 10 6.53e-01 7.27e-01 0.2530 0.186000 -0.148000 -0.003840 0.080400 -0.030800 3.08e-01 4.18e-01 9.83e-01 6.60e-01 8.66e-01
PLATELET SENSITIZATION BY LDL 15 6.90e-01 7.55e-01 0.2530 0.016200 0.049100 -0.037200 0.200000 -0.142000 9.14e-01 7.42e-01 8.03e-01 1.81e-01 3.42e-01
NICOTINAMIDE SALVAGING 14 4.13e-01 5.25e-01 0.2530 -0.017400 0.127000 -0.017900 -0.114000 -0.184000 9.10e-01 4.09e-01 9.08e-01 4.61e-01 2.33e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 175 2.91e-10 5.01e-09 0.2520 -0.114000 -0.123000 0.007180 0.181000 0.050500 9.51e-03 4.99e-03 8.70e-01 3.54e-05 2.50e-01
MICRORNA MIRNA BIOGENESIS 24 6.67e-01 7.39e-01 0.2520 0.138000 0.111000 0.132000 -0.101000 0.065800 2.41e-01 3.47e-01 2.61e-01 3.90e-01 5.77e-01
METALLOPROTEASE DUBS 24 5.12e-01 6.13e-01 0.2520 0.003020 -0.053400 -0.118000 -0.003910 -0.216000 9.80e-01 6.50e-01 3.16e-01 9.74e-01 6.70e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 4.47e-05 2.94e-04 0.2520 -0.071000 -0.126000 0.091500 0.180000 0.039000 2.64e-01 4.70e-02 1.50e-01 4.57e-03 5.39e-01
SIGNALING BY RETINOIC ACID 30 4.59e-01 5.71e-01 0.2510 0.015800 -0.062800 -0.056100 0.201000 -0.123000 8.81e-01 5.52e-01 5.95e-01 5.63e-02 2.42e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 3.85e-03 1.46e-02 0.2510 0.003970 -0.031400 -0.057100 0.065600 -0.233000 9.50e-01 6.21e-01 3.69e-01 3.02e-01 2.39e-04
NEUTROPHIL DEGRANULATION 374 6.15e-13 1.62e-11 0.2510 0.076500 0.025900 -0.056000 0.183000 -0.141000 1.14e-02 3.92e-01 6.40e-02 1.38e-09 3.00e-06
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 77 5.03e-04 2.56e-03 0.2510 -0.069900 -0.028900 0.146000 0.037400 0.186000 2.89e-01 6.62e-01 2.66e-02 5.71e-01 4.88e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 22 4.08e-01 5.20e-01 0.2500 -0.126000 0.098700 -0.137000 -0.094900 -0.096600 3.07e-01 4.23e-01 2.66e-01 4.41e-01 4.33e-01
CHROMATIN MODIFYING ENZYMES 216 1.45e-05 1.10e-04 0.2500 -0.008850 0.057600 0.132000 -0.139000 0.150000 8.23e-01 1.45e-01 8.33e-04 4.35e-04 1.54e-04
FANCONI ANEMIA PATHWAY 36 1.08e-01 2.00e-01 0.2500 0.163000 0.042700 0.133000 -0.128000 -0.018300 9.15e-02 6.57e-01 1.69e-01 1.84e-01 8.49e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 56 8.00e-02 1.61e-01 0.2500 -0.193000 -0.135000 -0.017200 -0.078000 -0.022100 1.23e-02 8.07e-02 8.24e-01 3.13e-01 7.75e-01
NEURONAL SYSTEM 359 4.60e-27 3.55e-25 0.2500 -0.150000 -0.076600 0.068100 0.120000 0.122000 1.07e-06 1.29e-02 2.71e-02 9.50e-05 7.59e-05
SENSORY PROCESSING OF SOUND 59 3.25e-01 4.46e-01 0.2500 0.049800 0.115000 0.148000 -0.025100 0.155000 5.08e-01 1.28e-01 4.90e-02 7.38e-01 3.89e-02
O LINKED GLYCOSYLATION 81 4.23e-04 2.26e-03 0.2500 0.029400 -0.094400 0.189000 0.071300 0.108000 6.47e-01 1.42e-01 3.29e-03 2.67e-01 9.26e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 1.89e-01 3.01e-01 0.2490 -0.077600 0.003350 -0.087100 0.165000 -0.146000 3.90e-01 9.70e-01 3.35e-01 6.74e-02 1.05e-01
FOXO MEDIATED TRANSCRIPTION 56 3.19e-01 4.40e-01 0.2490 -0.136000 -0.118000 -0.077500 -0.090600 -0.125000 7.84e-02 1.28e-01 3.16e-01 2.41e-01 1.07e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 9.07e-02 1.77e-01 0.2490 -0.027200 -0.060900 -0.097600 0.178000 -0.127000 6.96e-01 3.82e-01 1.61e-01 1.04e-02 6.74e-02
RUNX2 REGULATES BONE DEVELOPMENT 28 1.93e-01 3.06e-01 0.2490 -0.049100 -0.047800 0.101000 -0.001060 0.217000 6.53e-01 6.61e-01 3.53e-01 9.92e-01 4.70e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 1.49e-02 4.50e-02 0.2490 -0.185000 0.042000 0.028900 -0.093200 0.127000 1.85e-02 5.93e-01 7.13e-01 2.36e-01 1.06e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 1.65e-01 2.75e-01 0.2490 -0.210000 -0.110000 -0.038300 -0.034200 -0.056300 1.49e-02 2.04e-01 6.57e-01 6.91e-01 5.14e-01
NEUROTRANSMITTER RELEASE CYCLE 46 3.75e-03 1.43e-02 0.2480 -0.192000 0.000745 0.019100 0.088400 0.129000 2.45e-02 9.93e-01 8.22e-01 3.00e-01 1.29e-01
RET SIGNALING 36 1.43e-01 2.47e-01 0.2480 -0.008960 -0.017000 0.179000 0.044000 0.165000 9.26e-01 8.60e-01 6.37e-02 6.48e-01 8.67e-02
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 64 4.04e-04 2.17e-03 0.2470 0.067400 0.058700 -0.004760 -0.101000 -0.207000 3.51e-01 4.17e-01 9.48e-01 1.62e-01 4.19e-03
PROGRAMMED CELL DEATH 181 7.70e-06 6.31e-05 0.2470 0.044100 -0.009780 -0.103000 0.111000 -0.190000 3.07e-01 8.21e-01 1.75e-02 9.92e-03 1.10e-05
PROLACTIN RECEPTOR SIGNALING 11 8.63e-01 8.93e-01 0.2470 -0.000789 -0.030800 -0.089700 0.218000 -0.063600 9.96e-01 8.60e-01 6.07e-01 2.10e-01 7.15e-01
PRC2 METHYLATES HISTONES AND DNA 28 9.57e-02 1.84e-01 0.2460 0.071700 0.036900 -0.012100 -0.162000 -0.166000 5.11e-01 7.35e-01 9.12e-01 1.38e-01 1.28e-01
SIGNALLING TO RAS 17 7.59e-01 8.13e-01 0.2450 0.124000 0.007290 0.198000 0.020200 0.074000 3.77e-01 9.59e-01 1.59e-01 8.85e-01 5.98e-01
MITOTIC SPINDLE CHECKPOINT 94 1.20e-02 3.76e-02 0.2450 -0.001710 -0.028600 -0.172000 0.095900 -0.144000 9.77e-01 6.32e-01 3.98e-03 1.08e-01 1.62e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 4.37e-04 2.32e-03 0.2450 0.089200 -0.012100 -0.023200 -0.004240 -0.227000 1.76e-01 8.54e-01 7.25e-01 9.49e-01 5.93e-04
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 45 1.03e-01 1.95e-01 0.2440 0.057000 0.128000 0.195000 -0.041300 0.020400 5.08e-01 1.39e-01 2.36e-02 6.32e-01 8.12e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 64 5.31e-02 1.20e-01 0.2440 0.113000 -0.056100 0.043200 0.203000 -0.025700 1.19e-01 4.38e-01 5.50e-01 4.97e-03 7.22e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 8.14e-01 8.56e-01 0.2440 -0.101000 -0.073700 -0.086700 0.001070 -0.191000 4.58e-01 5.88e-01 5.24e-01 9.94e-01 1.61e-01
NETRIN 1 SIGNALING 48 8.96e-03 2.98e-02 0.2430 -0.143000 -0.095300 0.112000 -0.013400 0.130000 8.59e-02 2.54e-01 1.79e-01 8.72e-01 1.20e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 31 1.78e-01 2.89e-01 0.2430 0.138000 0.125000 0.124000 -0.065200 -0.069500 1.84e-01 2.29e-01 2.31e-01 5.30e-01 5.03e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 2.02e-01 3.16e-01 0.2430 0.009830 0.192000 0.091200 0.077100 0.088900 9.13e-01 3.35e-02 3.12e-01 3.93e-01 3.25e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 5.18e-07 5.21e-06 0.2430 -0.177000 0.049500 0.088800 0.129000 -0.024200 5.83e-03 4.41e-01 1.68e-01 4.47e-02 7.07e-01
BIOLOGICAL OXIDATIONS 120 2.42e-05 1.70e-04 0.2430 0.066200 0.103000 -0.020300 0.116000 -0.174000 2.11e-01 5.07e-02 7.01e-01 2.89e-02 1.04e-03
DAP12 SIGNALING 24 8.13e-01 8.56e-01 0.2420 -0.157000 -0.141000 -0.084800 -0.043000 -0.072100 1.84e-01 2.31e-01 4.72e-01 7.16e-01 5.41e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 61 5.53e-03 1.95e-02 0.2420 0.091600 0.131000 0.059300 -0.157000 -0.070600 2.16e-01 7.68e-02 4.23e-01 3.44e-02 3.41e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 3.73e-02 9.13e-02 0.2410 0.115000 0.186000 0.034300 -0.063200 -0.071300 1.74e-01 2.77e-02 6.84e-01 4.54e-01 3.98e-01
INTRA GOLGI TRAFFIC 43 3.96e-02 9.44e-02 0.2410 -0.021600 -0.128000 0.090800 0.181000 0.008710 8.07e-01 1.47e-01 3.03e-01 4.02e-02 9.21e-01
PLASMA LIPOPROTEIN REMODELING 13 5.16e-01 6.16e-01 0.2400 0.009390 -0.120000 0.200000 -0.043700 0.035000 9.53e-01 4.54e-01 2.12e-01 7.85e-01 8.27e-01
TNF SIGNALING 43 5.07e-01 6.08e-01 0.2400 0.118000 0.077500 0.095900 0.116000 0.122000 1.82e-01 3.79e-01 2.77e-01 1.87e-01 1.65e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 4.72e-01 5.76e-01 0.2400 -0.114000 -0.081500 -0.005800 0.194000 -0.005330 4.03e-01 5.49e-01 9.66e-01 1.54e-01 9.69e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 36 1.58e-01 2.67e-01 0.2400 -0.010800 0.040800 -0.109000 -0.042900 -0.204000 9.11e-01 6.72e-01 2.57e-01 6.56e-01 3.38e-02
PHASE I FUNCTIONALIZATION OF COMPOUNDS 57 9.32e-02 1.80e-01 0.2380 0.072000 0.199000 0.038600 0.101000 0.015700 3.47e-01 9.48e-03 6.14e-01 1.87e-01 8.37e-01
MITOTIC PROPHASE 91 3.68e-02 9.04e-02 0.2380 -0.081000 -0.100000 -0.056400 0.086400 -0.171000 1.82e-01 9.85e-02 3.53e-01 1.55e-01 4.88e-03
OTHER INTERLEUKIN SIGNALING 19 8.27e-01 8.68e-01 0.2380 0.112000 0.061200 0.084100 0.145000 0.110000 3.99e-01 6.44e-01 5.26e-01 2.74e-01 4.07e-01
AMINO ACIDS REGULATE MTORC1 51 8.80e-02 1.73e-01 0.2370 0.064000 -0.004660 0.007980 0.160000 -0.163000 4.30e-01 9.54e-01 9.21e-01 4.84e-02 4.41e-02
RHOJ GTPASE CYCLE 53 6.44e-03 2.22e-02 0.2370 -0.200000 0.017300 -0.068100 0.067900 0.081000 1.20e-02 8.27e-01 3.91e-01 3.93e-01 3.08e-01
APOPTOTIC EXECUTION PHASE 43 5.00e-01 6.00e-01 0.2370 -0.126000 -0.060700 -0.164000 0.042200 -0.087100 1.53e-01 4.91e-01 6.22e-02 6.33e-01 3.23e-01
RNA POLYMERASE I TRANSCRIPTION 66 1.00e-03 4.50e-03 0.2360 0.106000 0.125000 0.026100 -0.080100 -0.148000 1.36e-01 8.02e-02 7.14e-01 2.61e-01 3.83e-02
IRAK4 DEFICIENCY TLR2 4 12 8.40e-01 8.76e-01 0.2360 -0.104000 0.023100 -0.196000 -0.000346 -0.075800 5.33e-01 8.90e-01 2.39e-01 9.98e-01 6.49e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 5.38e-01 6.32e-01 0.2360 0.151000 0.175000 0.019900 -0.003420 -0.042300 2.42e-01 1.76e-01 8.78e-01 9.79e-01 7.43e-01
SIGNALING BY NOTCH2 32 6.18e-02 1.35e-01 0.2350 -0.055800 -0.055400 0.195000 0.064800 0.083200 5.85e-01 5.88e-01 5.63e-02 5.26e-01 4.15e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 233 1.51e-13 5.00e-12 0.2350 -0.112000 -0.088100 0.032100 0.166000 0.080000 3.38e-03 2.07e-02 4.00e-01 1.29e-05 3.57e-02
ION HOMEOSTASIS 47 2.82e-02 7.41e-02 0.2350 -0.172000 -0.062600 0.080600 -0.063600 0.104000 4.11e-02 4.58e-01 3.39e-01 4.51e-01 2.16e-01
RHOU GTPASE CYCLE 33 8.00e-02 1.61e-01 0.2340 -0.134000 -0.111000 -0.002670 0.049100 0.149000 1.84e-01 2.70e-01 9.79e-01 6.26e-01 1.38e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 7.49e-01 8.05e-01 0.2340 -0.170000 0.047500 0.019600 -0.096400 0.119000 3.08e-01 7.76e-01 9.06e-01 5.63e-01 4.77e-01
FRS MEDIATED FGFR3 SIGNALING 14 5.55e-01 6.47e-01 0.2340 -0.029000 0.146000 -0.148000 0.100000 -0.027900 8.51e-01 3.45e-01 3.38e-01 5.17e-01 8.57e-01
BASE EXCISION REPAIR 55 4.30e-03 1.58e-02 0.2340 0.113000 0.097400 0.019200 -0.053800 -0.170000 1.46e-01 2.12e-01 8.05e-01 4.90e-01 2.89e-02
ION TRANSPORT BY P TYPE ATPASES 47 6.55e-02 1.40e-01 0.2330 -0.079600 -0.022900 0.045600 -0.065000 0.203000 3.45e-01 7.86e-01 5.89e-01 4.41e-01 1.60e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 4.53e-01 5.65e-01 0.2330 0.041900 -0.011300 0.085900 0.189000 0.095700 7.12e-01 9.20e-01 4.49e-01 9.47e-02 3.98e-01
FLT3 SIGNALING IN DISEASE 27 8.84e-02 1.73e-01 0.2330 0.022100 -0.005920 -0.091300 -0.103000 0.186000 8.42e-01 9.58e-01 4.12e-01 3.53e-01 9.41e-02
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 12 8.60e-01 8.91e-01 0.2330 -0.120000 -0.101000 0.025500 -0.163000 0.046900 4.71e-01 5.46e-01 8.78e-01 3.27e-01 7.79e-01
APOPTOSIS 159 1.59e-04 9.30e-04 0.2330 0.042800 -0.005420 -0.094000 0.110000 -0.177000 3.53e-01 9.06e-01 4.10e-02 1.72e-02 1.17e-04
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 5.37e-02 1.21e-01 0.2320 0.053200 -0.001810 0.021100 0.064100 0.216000 5.46e-01 9.84e-01 8.11e-01 4.67e-01 1.43e-02
GLUCOSE METABOLISM 79 4.58e-02 1.06e-01 0.2320 0.139000 0.014700 0.122000 0.138000 -0.023300 3.27e-02 8.21e-01 6.07e-02 3.46e-02 7.21e-01
L1CAM INTERACTIONS 107 7.64e-04 3.65e-03 0.2320 -0.011400 0.047300 0.123000 0.134000 0.136000 8.38e-01 3.99e-01 2.84e-02 1.65e-02 1.55e-02
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 22 3.00e-01 4.22e-01 0.2320 -0.116000 -0.157000 0.026100 0.034300 0.118000 3.46e-01 2.03e-01 8.32e-01 7.80e-01 3.38e-01
SIGNALING BY NTRK2 TRKB 24 3.46e-01 4.67e-01 0.2310 -0.168000 -0.119000 -0.049900 0.063500 0.068300 1.54e-01 3.14e-01 6.72e-01 5.90e-01 5.62e-01
FRS MEDIATED FGFR1 SIGNALING 16 6.92e-01 7.56e-01 0.2310 -0.019500 0.052200 -0.124000 0.011400 -0.187000 8.92e-01 7.18e-01 3.92e-01 9.37e-01 1.95e-01
ACYL CHAIN REMODELLING OF PG 10 8.78e-01 9.04e-01 0.2310 -0.036400 -0.117000 -0.080300 0.179000 -0.008320 8.42e-01 5.22e-01 6.60e-01 3.28e-01 9.64e-01
MYOGENESIS 25 4.56e-01 5.68e-01 0.2310 -0.181000 -0.051300 -0.001180 -0.102000 0.085900 1.17e-01 6.57e-01 9.92e-01 3.77e-01 4.58e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 282 8.47e-06 6.80e-05 0.2300 -0.012400 -0.148000 -0.075100 0.092700 -0.130000 7.22e-01 2.08e-05 3.04e-02 7.51e-03 1.80e-04
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 4.99e-01 5.99e-01 0.2300 0.064800 -0.110000 0.020800 0.172000 -0.081500 5.68e-01 3.32e-01 8.55e-01 1.29e-01 4.72e-01
NEGATIVE REGULATION OF MAPK PATHWAY 41 8.28e-02 1.64e-01 0.2300 0.034600 -0.055600 0.089600 0.159000 -0.124000 7.02e-01 5.38e-01 3.21e-01 7.84e-02 1.70e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 4.62e-01 5.71e-01 0.2300 0.034700 0.053300 0.195000 0.093400 0.045600 7.74e-01 6.58e-01 1.06e-01 4.38e-01 7.05e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 2.20e-01 3.35e-01 0.2300 -0.210000 -0.052900 0.019300 -0.065800 0.032500 4.30e-02 6.10e-01 8.53e-01 5.26e-01 7.54e-01
MTOR SIGNALLING 40 3.77e-01 4.97e-01 0.2290 0.011500 -0.025200 -0.057900 0.177000 -0.131000 9.00e-01 7.83e-01 5.27e-01 5.29e-02 1.52e-01
BASE EXCISION REPAIR AP SITE FORMATION 28 1.45e-01 2.49e-01 0.2290 0.140000 0.083300 0.025700 -0.072200 -0.141000 2.01e-01 4.46e-01 8.14e-01 5.08e-01 1.95e-01
RHOV GTPASE CYCLE 32 7.56e-02 1.55e-01 0.2290 -0.099900 -0.075900 -0.056800 0.103000 0.151000 3.28e-01 4.58e-01 5.78e-01 3.13e-01 1.41e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 19 3.64e-01 4.85e-01 0.2280 -0.106000 0.174000 -0.096600 0.001030 0.038600 4.25e-01 1.90e-01 4.66e-01 9.94e-01 7.71e-01
INTERLEUKIN 1 FAMILY SIGNALING 119 2.32e-04 1.31e-03 0.2280 0.129000 0.095400 -0.059900 0.106000 -0.108000 1.55e-02 7.25e-02 2.60e-01 4.58e-02 4.21e-02
DEFECTS IN COBALAMIN B12 METABOLISM 12 8.75e-01 9.01e-01 0.2280 0.109000 0.027900 -0.026000 0.165000 -0.107000 5.12e-01 8.67e-01 8.76e-01 3.22e-01 5.21e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.49e-01 2.54e-01 0.2280 0.047700 -0.123000 0.029100 0.132000 -0.127000 5.84e-01 1.57e-01 7.39e-01 1.29e-01 1.44e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 22 6.20e-01 7.02e-01 0.2280 -0.034500 0.018900 -0.082400 0.193000 -0.079500 7.80e-01 8.78e-01 5.04e-01 1.18e-01 5.19e-01
RESOLUTION OF SISTER CHROMATID COHESION 98 7.13e-03 2.42e-02 0.2270 0.038300 0.048800 -0.104000 0.157000 -0.111000 5.13e-01 4.04e-01 7.64e-02 7.24e-03 5.83e-02
RND2 GTPASE CYCLE 38 1.61e-01 2.71e-01 0.2270 -0.058700 0.005140 0.093200 0.008540 0.198000 5.31e-01 9.56e-01 3.20e-01 9.27e-01 3.48e-02
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 1.86e-02 5.31e-02 0.2270 -0.039600 -0.036000 0.185000 0.047300 -0.109000 7.03e-01 7.29e-01 7.44e-02 6.49e-01 2.93e-01
TRP CHANNELS 18 5.18e-01 6.17e-01 0.2260 -0.036500 -0.054400 0.181000 -0.042100 0.111000 7.88e-01 6.90e-01 1.83e-01 7.57e-01 4.16e-01
GABA B RECEPTOR ACTIVATION 39 1.07e-01 1.98e-01 0.2260 -0.092300 -0.053500 -0.008110 0.199000 0.019100 3.19e-01 5.63e-01 9.30e-01 3.20e-02 8.36e-01
ENDOGENOUS STEROLS 20 5.95e-01 6.80e-01 0.2260 -0.008630 0.184000 -0.013300 -0.105000 0.078400 9.47e-01 1.55e-01 9.18e-01 4.16e-01 5.44e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 7.28e-01 7.88e-01 0.2260 0.095500 0.146000 0.113000 0.069400 -0.054800 5.08e-01 3.14e-01 4.35e-01 6.31e-01 7.04e-01
STIMULI SENSING CHANNELS 71 9.38e-03 3.10e-02 0.2250 -0.088000 -0.043200 0.122000 -0.057500 0.151000 2.00e-01 5.29e-01 7.45e-02 4.02e-01 2.75e-02
PLATELET HOMEOSTASIS 76 1.09e-01 2.00e-01 0.2250 -0.173000 -0.122000 -0.074300 -0.004890 -0.019500 9.22e-03 6.51e-02 2.63e-01 9.41e-01 7.70e-01
MUSCLE CONTRACTION 153 6.24e-06 5.15e-05 0.2250 -0.138000 0.032800 0.094300 -0.119000 0.088300 3.33e-03 4.84e-01 4.44e-02 1.15e-02 5.97e-02
SIGNAL TRANSDUCTION BY L1 21 3.81e-01 4.99e-01 0.2250 -0.065700 0.013000 0.043900 0.196000 -0.078100 6.02e-01 9.18e-01 7.27e-01 1.21e-01 5.35e-01
PI METABOLISM 79 3.29e-05 2.23e-04 0.2250 -0.157000 -0.069100 0.104000 0.099200 0.025400 1.62e-02 2.89e-01 1.11e-01 1.28e-01 6.96e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 6.51e-01 7.27e-01 0.2250 -0.193000 -0.084800 -0.061200 -0.030300 -0.034700 8.79e-02 4.54e-01 5.89e-01 7.89e-01 7.60e-01
ERYTHROPOIETIN ACTIVATES RAS 13 7.16e-01 7.76e-01 0.2240 -0.131000 0.008760 -0.058900 0.170000 -0.030300 4.15e-01 9.56e-01 7.13e-01 2.89e-01 8.50e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 17 4.99e-01 5.99e-01 0.2240 -0.124000 0.092200 -0.159000 -0.007670 0.033200 3.78e-01 5.10e-01 2.56e-01 9.56e-01 8.13e-01
REGULATION OF INSULIN SECRETION 70 5.49e-03 1.95e-02 0.2230 -0.043700 -0.005940 0.019700 0.195000 0.098800 5.28e-01 9.32e-01 7.76e-01 4.91e-03 1.53e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 4.39e-03 1.60e-02 0.2230 0.013000 0.220000 -0.026600 -0.011700 0.024000 8.42e-01 7.48e-04 6.83e-01 8.57e-01 7.13e-01
DISEASES OF PROGRAMMED CELL DEATH 53 1.60e-02 4.77e-02 0.2220 0.095400 0.045000 0.001010 0.000400 -0.196000 2.30e-01 5.71e-01 9.90e-01 9.96e-01 1.38e-02
GROWTH HORMONE RECEPTOR SIGNALING 20 5.52e-01 6.45e-01 0.2220 0.088500 -0.155000 0.012600 0.129000 -0.024000 4.93e-01 2.31e-01 9.22e-01 3.16e-01 8.53e-01
TELOMERE MAINTENANCE 77 7.24e-04 3.49e-03 0.2220 0.124000 0.006810 -0.003010 -0.041200 -0.179000 5.97e-02 9.18e-01 9.64e-01 5.32e-01 6.60e-03
RHO GTPASES ACTIVATE PAKS 21 3.71e-01 4.91e-01 0.2220 -0.096800 0.153000 -0.036000 0.015100 0.122000 4.43e-01 2.25e-01 7.75e-01 9.05e-01 3.32e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 4.98e-01 5.99e-01 0.2210 -0.102000 0.017700 0.164000 -0.096900 0.045200 4.78e-01 9.03e-01 2.57e-01 5.02e-01 7.54e-01
DUAL INCISION IN GG NER 40 5.02e-02 1.15e-01 0.2210 0.017500 0.088700 -0.020000 -0.067500 -0.189000 8.49e-01 3.32e-01 8.27e-01 4.60e-01 3.84e-02
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 339 1.18e-05 9.19e-05 0.2210 -0.014200 -0.113000 -0.097700 0.084400 -0.139000 6.55e-01 3.78e-04 2.06e-03 7.72e-03 1.19e-05
SUMOYLATION OF SUMOYLATION PROTEINS 33 4.86e-01 5.87e-01 0.2200 -0.191000 -0.086700 -0.043900 -0.047000 -0.009210 5.74e-02 3.89e-01 6.62e-01 6.40e-01 9.27e-01
RHOQ GTPASE CYCLE 56 6.52e-03 2.23e-02 0.2200 -0.198000 0.058000 0.033100 -0.013500 0.064700 1.02e-02 4.53e-01 6.68e-01 8.61e-01 4.02e-01
VXPX CARGO TARGETING TO CILIUM 19 6.17e-01 7.00e-01 0.2190 0.109000 0.045200 -0.037900 0.166000 0.073000 4.11e-01 7.33e-01 7.75e-01 2.11e-01 5.82e-01
ACYL CHAIN REMODELLING OF PS 14 5.38e-01 6.32e-01 0.2190 0.043200 -0.151000 0.118000 -0.007890 -0.096400 7.80e-01 3.27e-01 4.44e-01 9.59e-01 5.33e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 36 3.41e-01 4.64e-01 0.2190 -0.048000 -0.037400 -0.062800 0.198000 -0.031200 6.18e-01 6.98e-01 5.15e-01 3.95e-02 7.46e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 47 1.66e-01 2.76e-01 0.2180 0.107000 -0.078300 0.109000 0.112000 0.077000 2.06e-01 3.53e-01 1.97e-01 1.86e-01 3.61e-01
RND3 GTPASE CYCLE 37 2.21e-01 3.36e-01 0.2180 -0.034500 0.006230 0.115000 0.053700 0.174000 7.17e-01 9.48e-01 2.28e-01 5.72e-01 6.64e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION 20 4.60e-01 5.71e-01 0.2180 0.032400 -0.070300 0.176000 0.096700 0.035600 8.02e-01 5.87e-01 1.73e-01 4.54e-01 7.83e-01
RESOLUTION OF ABASIC SITES AP SITES 37 8.33e-02 1.65e-01 0.2180 0.080200 0.122000 -0.015100 -0.097900 -0.128000 3.99e-01 1.97e-01 8.74e-01 3.03e-01 1.79e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 5.91e-01 6.76e-01 0.2180 -0.023000 -0.069000 -0.022600 0.169000 -0.115000 8.33e-01 5.28e-01 8.36e-01 1.22e-01 2.93e-01
SIGNALLING TO ERKS 31 3.79e-01 4.99e-01 0.2180 -0.020100 -0.143000 0.022200 0.150000 -0.058900 8.46e-01 1.68e-01 8.31e-01 1.49e-01 5.71e-01
G PROTEIN ACTIVATION 21 5.17e-01 6.16e-01 0.2170 0.030000 -0.012100 -0.176000 0.107000 -0.058300 8.12e-01 9.24e-01 1.62e-01 3.95e-01 6.44e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.44e-01 7.21e-01 0.2170 -0.033900 0.159000 0.030000 -0.110000 -0.085700 8.32e-01 3.20e-01 8.51e-01 4.91e-01 5.93e-01
TRANSCRIPTION OF THE HIV GENOME 67 1.75e-02 5.11e-02 0.2160 0.041600 0.044700 -0.096000 -0.018600 -0.183000 5.56e-01 5.27e-01 1.75e-01 7.92e-01 9.59e-03
SIGNALING BY INSULIN RECEPTOR 60 3.11e-01 4.34e-01 0.2160 -0.056000 -0.080500 -0.064900 0.091300 -0.157000 4.53e-01 2.81e-01 3.85e-01 2.21e-01 3.61e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 6.71e-01 7.42e-01 0.2150 0.052000 0.088700 0.031800 0.182000 -0.039300 6.66e-01 4.61e-01 7.92e-01 1.30e-01 7.44e-01
PHOSPHOLIPID METABOLISM 183 4.06e-07 4.29e-06 0.2150 -0.014100 -0.011600 0.130000 0.152000 0.075600 7.43e-01 7.87e-01 2.38e-03 3.93e-04 7.81e-02
G ALPHA I SIGNALLING EVENTS 178 4.82e-07 4.98e-06 0.2150 -0.126000 -0.103000 -0.002110 0.140000 0.009280 3.88e-03 1.81e-02 9.61e-01 1.26e-03 8.31e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 6.52e-01 7.27e-01 0.2150 0.081800 -0.169000 -0.098700 0.019400 0.025300 6.39e-01 3.31e-01 5.71e-01 9.12e-01 8.85e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 2.59e-01 3.81e-01 0.2140 -0.036500 -0.017700 -0.043300 0.206000 0.004300 6.97e-01 8.50e-01 6.44e-01 2.84e-02 9.63e-01
RHOF GTPASE CYCLE 40 1.90e-01 3.02e-01 0.2140 -0.116000 -0.037600 -0.055500 0.167000 -0.011900 2.05e-01 6.80e-01 5.44e-01 6.84e-02 8.97e-01
SIGNALING BY ERYTHROPOIETIN 24 2.79e-01 4.00e-01 0.2140 -0.180000 0.058100 0.063600 -0.063700 0.040400 1.26e-01 6.22e-01 5.89e-01 5.89e-01 7.32e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 4.00e-03 1.51e-02 0.2130 -0.172000 -0.034200 0.084200 0.083800 0.018900 3.15e-02 6.69e-01 2.94e-01 2.96e-01 8.13e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 1.08e-02 3.46e-02 0.2120 0.131000 0.102000 -0.074100 -0.024900 -0.107000 8.27e-02 1.77e-01 3.25e-01 7.41e-01 1.54e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 4.07e-01 5.20e-01 0.2120 0.061200 -0.019700 -0.015200 0.199000 0.033000 5.37e-01 8.42e-01 8.78e-01 4.49e-02 7.40e-01
NUCLEOTIDE EXCISION REPAIR 109 7.99e-04 3.77e-03 0.2120 0.040800 -0.033200 -0.021600 0.012500 -0.203000 4.62e-01 5.50e-01 6.98e-01 8.22e-01 2.45e-04
INTRINSIC PATHWAY FOR APOPTOSIS 50 3.40e-01 4.62e-01 0.2100 -0.059600 -0.083900 -0.039400 0.134000 -0.118000 4.66e-01 3.05e-01 6.30e-01 1.01e-01 1.48e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 1.99e-01 3.11e-01 0.2100 0.108000 0.156000 0.068500 -0.057900 0.007540 1.52e-01 3.86e-02 3.63e-01 4.42e-01 9.20e-01
GPVI MEDIATED ACTIVATION CASCADE 31 1.06e-01 1.97e-01 0.2080 -0.091800 0.051400 0.044400 0.107000 -0.138000 3.76e-01 6.20e-01 6.69e-01 3.03e-01 1.85e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 49 1.85e-02 5.31e-02 0.2070 -0.078900 -0.139000 0.117000 0.055200 -0.025200 3.39e-01 9.18e-02 1.56e-01 5.04e-01 7.61e-01
REGULATION OF FZD BY UBIQUITINATION 19 5.43e-01 6.37e-01 0.2070 0.164000 -0.077400 -0.013300 0.097500 0.018900 2.15e-01 5.59e-01 9.20e-01 4.62e-01 8.86e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 21 7.87e-01 8.37e-01 0.2070 0.052600 0.014700 -0.006510 0.193000 -0.051100 6.76e-01 9.07e-01 9.59e-01 1.27e-01 6.85e-01
CHROMOSOME MAINTENANCE 100 9.62e-04 4.38e-03 0.2070 0.060400 0.021000 -0.065000 -0.046700 -0.179000 2.97e-01 7.17e-01 2.62e-01 4.20e-01 1.94e-03
IRS MEDIATED SIGNALLING 36 7.51e-01 8.07e-01 0.2060 -0.140000 -0.068100 -0.069300 -0.084500 -0.077500 1.46e-01 4.80e-01 4.72e-01 3.80e-01 4.21e-01
SIGNALING BY VEGF 101 1.79e-05 1.31e-04 0.2050 -0.167000 0.013200 0.039000 0.111000 -0.014100 3.77e-03 8.19e-01 4.99e-01 5.36e-02 8.07e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 6.53e-02 1.40e-01 0.2040 0.062900 0.141000 0.024400 0.018400 0.130000 2.87e-01 1.73e-02 6.80e-01 7.55e-01 2.81e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.52e-01 3.74e-01 0.2030 0.094700 0.071300 -0.042000 -0.083800 -0.136000 3.86e-01 5.14e-01 7.00e-01 4.43e-01 2.14e-01
ONCOGENE INDUCED SENESCENCE 32 5.67e-01 6.58e-01 0.2030 0.050500 -0.021300 0.129000 0.047000 0.139000 6.21e-01 8.35e-01 2.06e-01 6.45e-01 1.74e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 8.43e-01 8.78e-01 0.2030 0.124000 0.052100 -0.015500 0.045000 -0.144000 4.77e-01 7.65e-01 9.29e-01 7.96e-01 4.08e-01
AMYLOID FIBER FORMATION 55 1.10e-02 3.51e-02 0.2030 0.080100 -0.028600 0.096100 -0.031000 -0.154000 3.05e-01 7.14e-01 2.18e-01 6.91e-01 4.87e-02
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 7.76e-02 1.57e-01 0.2020 -0.024800 -0.073200 -0.025600 0.168000 -0.078600 6.89e-01 2.39e-01 6.80e-01 6.90e-03 2.05e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 7.91e-01 8.38e-01 0.2020 0.087800 0.045700 0.163000 0.054800 0.036200 4.66e-01 7.04e-01 1.75e-01 6.49e-01 7.64e-01
AQUAPORIN MEDIATED TRANSPORT 39 4.04e-01 5.18e-01 0.2010 -0.074000 -0.008630 -0.062500 0.161000 -0.072700 4.24e-01 9.26e-01 4.99e-01 8.29e-02 4.32e-01
PECAM1 INTERACTIONS 12 7.36e-01 7.95e-01 0.2000 -0.158000 0.019200 0.076300 -0.023100 0.091500 3.42e-01 9.08e-01 6.47e-01 8.90e-01 5.83e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 4.08e-01 5.20e-01 0.2000 -0.088700 -0.055900 -0.159000 0.060800 0.006230 3.71e-01 5.72e-01 1.09e-01 5.39e-01 9.50e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 593 4.36e-21 2.52e-19 0.2000 0.093600 0.091100 -0.036200 0.042100 -0.141000 1.06e-04 1.62e-04 1.34e-01 8.16e-02 5.72e-09
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 9.66e-01 9.74e-01 0.2000 0.078100 0.065000 0.076200 0.068800 0.138000 6.40e-01 6.97e-01 6.48e-01 6.80e-01 4.08e-01
CLATHRIN MEDIATED ENDOCYTOSIS 129 1.23e-03 5.42e-03 0.2000 -0.018500 -0.082200 0.040800 0.163000 -0.066400 7.17e-01 1.07e-01 4.24e-01 1.37e-03 1.93e-01
MITOTIC G2 G2 M PHASES 183 2.21e-05 1.57e-04 0.2000 0.108000 0.085700 -0.058500 0.084100 -0.102000 1.20e-02 4.59e-02 1.73e-01 5.01e-02 1.78e-02
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 62 6.90e-01 7.55e-01 0.1990 -0.090200 -0.093400 -0.106000 -0.033000 -0.103000 2.20e-01 2.04e-01 1.51e-01 6.54e-01 1.60e-01
DISEASES OF IMMUNE SYSTEM 23 7.68e-01 8.21e-01 0.1990 -0.013900 0.144000 0.050700 -0.106000 0.071000 9.08e-01 2.33e-01 6.74e-01 3.80e-01 5.56e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 6.28e-01 7.09e-01 0.1990 -0.087400 -0.064800 0.165000 -0.015000 -0.021300 6.16e-01 7.10e-01 3.45e-01 9.32e-01 9.03e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 89 6.50e-02 1.40e-01 0.1990 -0.025300 -0.107000 -0.007880 0.139000 -0.089700 6.81e-01 8.14e-02 8.98e-01 2.33e-02 1.44e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 106 4.80e-03 1.74e-02 0.1990 0.085500 -0.023500 -0.107000 0.043300 -0.135000 1.29e-01 6.76e-01 5.67e-02 4.42e-01 1.61e-02
DEADENYLATION DEPENDENT MRNA DECAY 55 5.73e-01 6.61e-01 0.1990 -0.079500 -0.041900 -0.114000 -0.062700 -0.120000 3.08e-01 5.91e-01 1.45e-01 4.21e-01 1.23e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 20 7.72e-01 8.23e-01 0.1980 0.051900 0.017400 -0.104000 0.128000 -0.095700 6.88e-01 8.93e-01 4.20e-01 3.23e-01 4.59e-01
ARACHIDONIC ACID METABOLISM 37 1.07e-01 1.99e-01 0.1980 0.024300 0.103000 0.021500 -0.042500 -0.160000 7.98e-01 2.77e-01 8.21e-01 6.55e-01 9.22e-02
POST TRANSLATIONAL PROTEIN MODIFICATION 1188 1.04e-23 7.09e-22 0.1980 0.010800 -0.084400 -0.015000 0.146000 -0.102000 5.35e-01 1.25e-06 3.89e-01 5.78e-17 4.73e-09
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 9.25e-01 9.41e-01 0.1970 0.067400 0.071600 0.025800 0.163000 -0.044100 6.74e-01 6.55e-01 8.72e-01 3.08e-01 7.83e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 25 5.51e-01 6.44e-01 0.1970 0.051600 0.033400 0.032900 0.119000 -0.140000 6.55e-01 7.73e-01 7.76e-01 3.04e-01 2.24e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 2.51e-01 3.73e-01 0.1960 -0.054400 -0.040400 -0.012400 0.177000 -0.048900 5.14e-01 6.28e-01 8.82e-01 3.39e-02 5.58e-01
DEATH RECEPTOR SIGNALLING 132 1.64e-03 7.00e-03 0.1960 -0.016200 0.042600 0.162000 0.027500 0.096500 7.49e-01 3.99e-01 1.31e-03 5.86e-01 5.59e-02
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 104 2.48e-02 6.71e-02 0.1960 0.054500 0.084100 -0.006360 0.147000 -0.082300 3.37e-01 1.39e-01 9.11e-01 9.71e-03 1.47e-01
SIGNALING BY SCF KIT 41 2.66e-01 3.87e-01 0.1960 -0.080600 -0.134000 -0.069100 0.085200 0.042700 3.72e-01 1.37e-01 4.44e-01 3.45e-01 6.36e-01
SIGNALING BY PDGF 55 5.12e-01 6.13e-01 0.1950 0.036800 0.142000 0.089500 -0.057300 0.073000 6.37e-01 6.89e-02 2.51e-01 4.63e-01 3.49e-01
M PHASE 333 2.37e-07 2.56e-06 0.1950 0.040000 0.022100 -0.091000 0.096700 -0.135000 2.11e-01 4.89e-01 4.43e-03 2.49e-03 2.28e-05
SIGNALING BY NOTCH3 48 1.12e-01 2.05e-01 0.1950 -0.058900 0.007960 0.161000 -0.024500 0.089400 4.80e-01 9.24e-01 5.43e-02 7.69e-01 2.84e-01
EGFR DOWNREGULATION 27 3.96e-01 5.10e-01 0.1940 -0.066800 -0.081700 0.057100 0.149000 -0.030600 5.48e-01 4.63e-01 6.08e-01 1.79e-01 7.83e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 1.78e-01 2.89e-01 0.1940 -0.017900 -0.017800 -0.053800 0.166000 -0.080000 7.88e-01 7.90e-01 4.21e-01 1.28e-02 2.32e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 3.75e-02 9.14e-02 0.1940 0.021900 -0.070700 -0.002020 0.106000 0.144000 7.77e-01 3.61e-01 9.79e-01 1.70e-01 6.19e-02
RHO GTPASES ACTIVATE KTN1 11 8.87e-01 9.11e-01 0.1930 -0.016100 0.068900 -0.075300 0.027200 -0.161000 9.26e-01 6.92e-01 6.65e-01 8.76e-01 3.55e-01
HOMOLOGY DIRECTED REPAIR 105 4.49e-02 1.04e-01 0.1920 -0.052200 -0.061600 -0.032800 -0.136000 -0.104000 3.56e-01 2.76e-01 5.62e-01 1.59e-02 6.71e-02
MEIOSIS 61 5.82e-01 6.68e-01 0.1920 -0.102000 -0.034200 -0.111000 -0.069900 -0.090200 1.70e-01 6.45e-01 1.34e-01 3.45e-01 2.23e-01
SIGNALING BY NTRKS 127 1.47e-04 8.70e-04 0.1920 -0.037900 -0.098500 0.079600 0.119000 -0.070900 4.61e-01 5.55e-02 1.22e-01 2.05e-02 1.68e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 5.73e-01 6.61e-01 0.1910 -0.154000 -0.084300 -0.013700 -0.073500 -0.011200 1.05e-01 3.75e-01 8.85e-01 4.39e-01 9.06e-01
CELL JUNCTION ORGANIZATION 71 3.95e-02 9.44e-02 0.1910 -0.117000 -0.139000 0.022200 0.055500 0.003630 8.95e-02 4.27e-02 7.46e-01 4.19e-01 9.58e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 8.74e-01 9.01e-01 0.1910 0.145000 -0.082400 0.005180 0.092200 -0.000835 4.04e-01 6.36e-01 9.76e-01 5.97e-01 9.96e-01
NUCLEOBASE CATABOLISM 31 5.31e-01 6.27e-01 0.1910 0.042500 -0.030600 -0.084200 0.163000 -0.011000 6.82e-01 7.68e-01 4.17e-01 1.17e-01 9.15e-01
SIGNALING BY MET 73 2.93e-01 4.16e-01 0.1900 0.028300 0.144000 0.053700 0.021800 0.107000 6.76e-01 3.38e-02 4.28e-01 7.48e-01 1.14e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 8.65e-01 8.93e-01 0.1900 0.127000 0.103000 0.091200 0.012500 0.031300 2.29e-01 3.28e-01 3.87e-01 9.06e-01 7.67e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 5.76e-01 6.63e-01 0.1900 -0.165000 -0.060000 -0.000130 -0.073100 -0.003940 1.13e-01 5.63e-01 9.99e-01 4.81e-01 9.70e-01
HCMV EARLY EVENTS 78 2.26e-01 3.42e-01 0.1900 0.086200 0.098000 0.133000 0.035600 0.009150 1.88e-01 1.35e-01 4.26e-02 5.87e-01 8.89e-01
SIGNALING BY NOTCH1 75 1.63e-01 2.72e-01 0.1890 -0.004120 0.035200 0.134000 0.014100 0.128000 9.51e-01 5.98e-01 4.44e-02 8.33e-01 5.57e-02
HCMV INFECTION 101 1.28e-02 3.97e-02 0.1890 0.093600 0.059000 0.104000 0.079600 -0.079400 1.04e-01 3.06e-01 6.99e-02 1.67e-01 1.69e-01
HIV TRANSCRIPTION ELONGATION 42 1.18e-01 2.13e-01 0.1890 0.103000 0.051300 0.042700 -0.045000 -0.136000 2.48e-01 5.66e-01 6.32e-01 6.14e-01 1.26e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 92 1.73e-02 5.07e-02 0.1890 0.128000 0.049900 -0.036800 0.063600 -0.106000 3.33e-02 4.08e-01 5.42e-01 2.92e-01 7.80e-02
CELL CYCLE MITOTIC 466 8.10e-09 1.11e-07 0.1890 0.021200 0.005590 -0.086600 0.088300 -0.141000 4.34e-01 8.37e-01 1.42e-03 1.14e-03 1.99e-07
TELOMERE EXTENSION BY TELOMERASE 22 8.29e-01 8.69e-01 0.1890 0.117000 0.107000 0.002750 0.089800 0.048900 3.40e-01 3.85e-01 9.82e-01 4.66e-01 6.91e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 9.46e-01 9.59e-01 0.1890 0.145000 0.039700 0.061800 0.085100 0.043200 3.14e-01 7.83e-01 6.69e-01 5.56e-01 7.65e-01
GPCR LIGAND BINDING 226 8.31e-06 6.71e-05 0.1880 0.006080 -0.082500 0.037300 0.163000 0.023800 8.75e-01 3.29e-02 3.35e-01 2.47e-05 5.38e-01
P38MAPK EVENTS 12 8.39e-01 8.76e-01 0.1880 0.075200 0.018900 0.158000 0.047100 -0.046900 6.52e-01 9.10e-01 3.44e-01 7.78e-01 7.79e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 7.95e-01 8.40e-01 0.1880 -0.068000 -0.136000 0.014400 0.109000 -0.004090 6.38e-01 3.46e-01 9.21e-01 4.51e-01 9.77e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 7.69e-01 8.22e-01 0.1870 0.126000 0.042000 0.089500 0.055000 -0.078800 3.40e-01 7.51e-01 5.00e-01 6.78e-01 5.52e-01
ADAPTIVE IMMUNE SYSTEM 584 7.78e-08 9.17e-07 0.1870 -0.012600 -0.079300 -0.062800 0.119000 -0.101000 6.06e-01 1.11e-03 9.88e-03 9.48e-07 3.17e-05
MEMBRANE TRAFFICKING 571 5.11e-12 1.14e-10 0.1870 0.024000 -0.045600 0.030700 0.170000 -0.048200 3.30e-01 6.36e-02 2.13e-01 4.72e-12 5.00e-02
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 40 6.85e-01 7.52e-01 0.1860 -0.141000 -0.038600 -0.046000 -0.100000 -0.036300 1.24e-01 6.73e-01 6.15e-01 2.73e-01 6.91e-01
SLC TRANSPORTER DISORDERS 67 1.95e-01 3.07e-01 0.1860 -0.146000 -0.111000 -0.019000 -0.021300 0.008160 3.82e-02 1.17e-01 7.88e-01 7.63e-01 9.08e-01
CELLULAR RESPONSE TO HEAT STRESS 94 7.74e-02 1.57e-01 0.1850 0.017800 0.028100 -0.001980 0.173000 -0.059100 7.66e-01 6.38e-01 9.74e-01 3.86e-03 3.23e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 4.48e-01 5.61e-01 0.1850 -0.129000 -0.102000 -0.049400 -0.021300 -0.066900 5.84e-02 1.36e-01 4.69e-01 7.55e-01 3.27e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 64 1.05e-01 1.96e-01 0.1850 -0.001550 0.013900 0.106000 -0.150000 -0.004100 9.83e-01 8.48e-01 1.42e-01 3.75e-02 9.55e-01
HIV LIFE CYCLE 142 5.16e-03 1.85e-02 0.1850 0.009880 0.022100 -0.080000 0.034000 -0.161000 8.39e-01 6.49e-01 1.00e-01 4.84e-01 9.34e-04
RAC2 GTPASE CYCLE 86 3.26e-03 1.27e-02 0.1850 -0.152000 0.039700 -0.024500 0.076600 0.054800 1.51e-02 5.25e-01 6.95e-01 2.20e-01 3.80e-01
FLT3 SIGNALING 36 3.64e-01 4.85e-01 0.1840 -0.072400 -0.107000 -0.026700 -0.063300 0.112000 4.52e-01 2.68e-01 7.81e-01 5.11e-01 2.43e-01
INSULIN RECEPTOR SIGNALLING CASCADE 41 7.64e-01 8.18e-01 0.1840 -0.140000 -0.076300 -0.061400 -0.033300 -0.058400 1.20e-01 3.98e-01 4.97e-01 7.12e-01 5.18e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 8.19e-01 8.61e-01 0.1830 0.014800 -0.121000 -0.101000 0.024800 -0.089200 9.00e-01 3.06e-01 3.92e-01 8.34e-01 4.49e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 8.96e-01 9.17e-01 0.1830 -0.109000 -0.069800 -0.075800 -0.021100 -0.103000 2.88e-01 4.94e-01 4.58e-01 8.37e-01 3.11e-01
NICOTINATE METABOLISM 23 3.32e-01 4.54e-01 0.1830 -0.054900 0.090000 0.045200 0.021400 -0.141000 6.48e-01 4.55e-01 7.07e-01 8.59e-01 2.42e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 102 8.82e-03 2.94e-02 0.1830 0.042500 0.064700 0.020600 -0.156000 -0.050500 4.59e-01 2.60e-01 7.19e-01 6.40e-03 3.79e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 4.50e-01 5.63e-01 0.1820 -0.035500 0.140000 -0.080800 -0.052400 -0.055000 7.45e-01 1.99e-01 4.59e-01 6.31e-01 6.14e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 151 6.23e-04 3.07e-03 0.1820 -0.023200 -0.090700 0.028600 0.151000 0.029100 6.23e-01 5.46e-02 5.45e-01 1.39e-03 5.37e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 73 1.36e-01 2.37e-01 0.1820 -0.046000 0.035400 0.126000 -0.065700 0.097600 4.97e-01 6.01e-01 6.29e-02 3.32e-01 1.50e-01
IRAK1 RECRUITS IKK COMPLEX 14 9.78e-01 9.83e-01 0.1810 0.083400 0.122000 0.054100 -0.008000 0.089900 5.89e-01 4.30e-01 7.26e-01 9.59e-01 5.60e-01
ESTROGEN DEPENDENT GENE EXPRESSION 99 6.52e-02 1.40e-01 0.1810 -0.062700 -0.018400 -0.004630 -0.157000 -0.061300 2.81e-01 7.52e-01 9.37e-01 6.93e-03 2.92e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 17 6.54e-01 7.28e-01 0.1810 0.054600 -0.036600 0.157000 0.037900 -0.047900 6.97e-01 7.94e-01 2.63e-01 7.87e-01 7.32e-01
SIGNALING BY TGFB FAMILY MEMBERS 95 3.90e-01 5.03e-01 0.1800 -0.112000 -0.091300 -0.089200 0.030600 -0.051100 6.05e-02 1.24e-01 1.33e-01 6.07e-01 3.90e-01
SIGNALING BY WNT IN CANCER 30 4.79e-01 5.82e-01 0.1790 -0.049900 -0.151000 0.032400 0.072600 0.018100 6.36e-01 1.51e-01 7.59e-01 4.91e-01 8.64e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 7.12e-01 7.73e-01 0.1790 -0.133000 -0.096600 -0.054500 0.032000 -0.029600 1.66e-01 3.16e-01 5.72e-01 7.40e-01 7.59e-01
HCMV LATE EVENTS 63 1.60e-02 4.77e-02 0.1780 -0.013400 -0.053200 0.078000 -0.030500 -0.148000 8.54e-01 4.66e-01 2.85e-01 6.75e-01 4.26e-02
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 9.24e-01 9.41e-01 0.1780 -0.103000 -0.098800 0.004330 0.039600 -0.098600 5.38e-01 5.53e-01 9.79e-01 8.12e-01 5.54e-01
INNATE IMMUNE SYSTEM 757 3.53e-13 1.02e-11 0.1770 0.017200 0.013900 -0.042300 0.119000 -0.123000 4.24e-01 5.17e-01 4.90e-02 3.27e-08 1.19e-08
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 89 1.73e-02 5.07e-02 0.1770 -0.136000 -0.048900 0.005880 0.074000 -0.071000 2.72e-02 4.26e-01 9.24e-01 2.28e-01 2.47e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 16 9.59e-01 9.70e-01 0.1770 -0.049100 -0.058400 -0.061300 0.041400 -0.141000 7.34e-01 6.86e-01 6.71e-01 7.74e-01 3.29e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 2.54e-01 3.75e-01 0.1760 0.101000 0.045900 0.016800 -0.133000 -0.028800 2.53e-01 6.03e-01 8.48e-01 1.31e-01 7.44e-01
REPRODUCTION 73 3.02e-01 4.25e-01 0.1760 -0.099900 0.023800 -0.096600 -0.096800 -0.042500 1.40e-01 7.26e-01 1.54e-01 1.53e-01 5.31e-01
SIGNALING BY ERBB4 56 2.52e-01 3.73e-01 0.1760 -0.088100 -0.027100 -0.114000 0.097000 0.002590 2.55e-01 7.25e-01 1.40e-01 2.09e-01 9.73e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 8.58e-01 8.90e-01 0.1750 -0.061200 0.027300 0.096800 0.057200 0.116000 7.02e-01 8.64e-01 5.46e-01 7.21e-01 4.68e-01
VESICLE MEDIATED TRANSPORT 599 1.07e-10 1.93e-09 0.1750 0.030900 -0.032700 0.032800 0.161000 -0.040900 1.99e-01 1.74e-01 1.72e-01 2.35e-11 8.91e-02
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 5.71e-01 6.61e-01 0.1740 0.081300 0.114000 0.074200 0.044500 0.058100 1.96e-01 7.02e-02 2.37e-01 4.79e-01 3.55e-01
PTEN REGULATION 132 1.34e-02 4.12e-02 0.1740 0.105000 0.074600 -0.020900 0.082100 -0.080800 3.70e-02 1.39e-01 6.78e-01 1.04e-01 1.09e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 60 8.89e-02 1.74e-01 0.1740 -0.131000 -0.021400 -0.036900 0.097400 0.042300 7.98e-02 7.74e-01 6.21e-01 1.92e-01 5.71e-01
EXTENSION OF TELOMERES 49 1.79e-01 2.90e-01 0.1740 0.105000 0.043300 -0.048000 0.002050 -0.122000 2.03e-01 6.00e-01 5.61e-01 9.80e-01 1.40e-01
G ALPHA S SIGNALLING EVENTS 94 6.77e-03 2.31e-02 0.1730 -0.055300 -0.049000 0.118000 0.055900 0.086300 3.55e-01 4.12e-01 4.77e-02 3.50e-01 1.48e-01
RAC3 GTPASE CYCLE 88 1.34e-02 4.12e-02 0.1730 -0.149000 -0.024500 -0.021900 0.059000 0.057200 1.59e-02 6.91e-01 7.23e-01 3.39e-01 3.54e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 8.88e-01 9.11e-01 0.1730 0.046800 -0.006470 -0.040000 0.158000 -0.033800 7.17e-01 9.60e-01 7.57e-01 2.22e-01 7.94e-01
RHO GTPASES ACTIVATE FORMINS 116 6.83e-02 1.44e-01 0.1730 0.030200 0.029400 -0.026600 0.137000 -0.092700 5.74e-01 5.84e-01 6.21e-01 1.08e-02 8.49e-02
NONHOMOLOGOUS END JOINING NHEJ 42 8.62e-01 8.92e-01 0.1720 -0.072700 -0.069700 -0.076800 -0.026900 -0.114000 4.15e-01 4.35e-01 3.89e-01 7.63e-01 2.01e-01
SIGNALING BY CSF3 G CSF 29 7.05e-01 7.68e-01 0.1720 0.015800 -0.116000 -0.097500 0.071200 -0.037800 8.83e-01 2.80e-01 3.64e-01 5.07e-01 7.25e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 35 3.17e-01 4.39e-01 0.1720 -0.018800 0.005320 0.010600 -0.041500 -0.166000 8.48e-01 9.57e-01 9.14e-01 6.71e-01 9.01e-02
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 174 1.02e-03 4.58e-03 0.1720 0.092900 0.042400 -0.013000 0.066000 -0.121000 3.49e-02 3.35e-01 7.68e-01 1.34e-01 5.95e-03
REGULATION OF LIPID METABOLISM BY PPARALPHA 105 3.05e-02 7.80e-02 0.1720 -0.074000 -0.035700 0.082700 -0.066300 0.107000 1.90e-01 5.28e-01 1.44e-01 2.41e-01 5.75e-02
BETA CATENIN INDEPENDENT WNT SIGNALING 137 1.89e-02 5.39e-02 0.1720 0.085500 0.009490 -0.053100 0.096200 -0.100000 8.45e-02 8.48e-01 2.84e-01 5.22e-02 4.33e-02
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 26 4.73e-01 5.76e-01 0.1710 -0.099700 -0.070900 0.050800 0.105000 0.027600 3.79e-01 5.31e-01 6.54e-01 3.53e-01 8.08e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 26 6.87e-01 7.53e-01 0.1710 0.016900 0.035000 -0.017300 0.080200 -0.145000 8.82e-01 7.57e-01 8.79e-01 4.79e-01 2.01e-01
SIGNALING BY GPCR 438 9.43e-15 3.89e-13 0.1710 -0.075100 -0.058300 0.077100 0.099500 0.065400 7.25e-03 3.70e-02 5.88e-03 3.75e-04 1.95e-02
SIGNALING BY ACTIVIN 11 9.22e-01 9.40e-01 0.1710 -0.056900 -0.131000 -0.074900 0.017900 0.052100 7.44e-01 4.51e-01 6.67e-01 9.18e-01 7.65e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 6.61e-01 7.34e-01 0.1710 0.003310 0.087900 0.044600 -0.002890 0.139000 9.71e-01 3.30e-01 6.22e-01 9.75e-01 1.23e-01
ACYL CHAIN REMODELLING OF PC 16 7.98e-01 8.42e-01 0.1690 -0.043500 0.008640 0.021100 0.111000 0.117000 7.63e-01 9.52e-01 8.84e-01 4.43e-01 4.17e-01
INTERLEUKIN 17 SIGNALING 66 1.92e-01 3.05e-01 0.1680 -0.061300 -0.097100 0.018600 0.083700 -0.087700 3.90e-01 1.73e-01 7.93e-01 2.40e-01 2.18e-01
PEPTIDE LIGAND BINDING RECEPTORS 86 1.54e-01 2.61e-01 0.1680 0.081400 -0.034900 -0.016100 0.142000 0.005770 1.92e-01 5.76e-01 7.96e-01 2.34e-02 9.26e-01
GLYCOLYSIS 65 4.75e-01 5.79e-01 0.1680 0.123000 0.002670 0.072200 0.087900 0.001510 8.61e-02 9.70e-01 3.14e-01 2.21e-01 9.83e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 1.73e-01 2.84e-01 0.1670 0.097900 0.111000 0.001280 -0.034600 -0.069400 2.01e-01 1.47e-01 9.87e-01 6.52e-01 3.65e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 176 1.81e-05 1.33e-04 0.1670 -0.069900 -0.037100 0.110000 0.056600 0.079800 1.10e-01 3.96e-01 1.19e-02 1.96e-01 6.83e-02
GENERATION OF SECOND MESSENGER MOLECULES 19 8.58e-01 8.90e-01 0.1670 -0.077500 0.052400 -0.073300 -0.060300 -0.101000 5.59e-01 6.92e-01 5.80e-01 6.49e-01 4.48e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 16 8.36e-01 8.74e-01 0.1670 -0.002540 0.018500 -0.009680 0.040300 -0.161000 9.86e-01 8.98e-01 9.47e-01 7.80e-01 2.66e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 9.02e-01 9.22e-01 0.1670 0.122000 0.066200 0.076200 0.038500 -0.034200 3.45e-01 6.08e-01 5.55e-01 7.66e-01 7.91e-01
G ALPHA Q SIGNALLING EVENTS 141 2.39e-03 9.63e-03 0.1660 -0.063900 -0.013700 -0.009260 0.149000 0.031100 1.91e-01 7.79e-01 8.50e-01 2.22e-03 5.24e-01
CELL CYCLE 581 4.50e-08 5.47e-07 0.1660 0.009440 -0.001290 -0.090200 0.063100 -0.124000 6.99e-01 9.58e-01 2.17e-04 9.73e-03 3.58e-07
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 6.72e-01 7.42e-01 0.1660 -0.136000 -0.013600 0.022800 -0.076100 0.048200 2.04e-01 8.99e-01 8.32e-01 4.79e-01 6.53e-01
SIGNALING BY EGFR 46 2.42e-01 3.61e-01 0.1650 -0.061200 0.027100 0.064800 0.105000 0.088000 4.73e-01 7.50e-01 4.47e-01 2.20e-01 3.02e-01
TRNA PROCESSING IN THE NUCLEUS 56 2.57e-01 3.77e-01 0.1650 -0.075500 -0.012100 -0.012900 0.054300 -0.135000 3.29e-01 8.75e-01 8.68e-01 4.82e-01 8.02e-02
TP53 REGULATES METABOLIC GENES 84 3.63e-01 4.84e-01 0.1650 -0.033400 -0.068000 -0.054400 -0.034700 -0.131000 5.97e-01 2.82e-01 3.89e-01 5.83e-01 3.75e-02
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 7.83e-01 8.34e-01 0.1650 -0.140000 -0.041700 -0.059600 0.005920 -0.047400 1.52e-01 6.70e-01 5.42e-01 9.52e-01 6.28e-01
SIGNALING BY FGFR1 42 5.89e-01 6.74e-01 0.1650 -0.098700 0.001660 -0.058600 0.070900 -0.094400 2.69e-01 9.85e-01 5.11e-01 4.27e-01 2.90e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 218 2.09e-04 1.19e-03 0.1650 -0.007290 0.044700 0.027300 0.144000 -0.059200 8.53e-01 2.57e-01 4.89e-01 2.50e-04 1.33e-01
SIGNALING BY EGFR IN CANCER 21 7.90e-01 8.38e-01 0.1640 -0.139000 0.038400 -0.046600 -0.018600 -0.061300 2.71e-01 7.61e-01 7.12e-01 8.83e-01 6.27e-01
RHOH GTPASE CYCLE 37 8.57e-01 8.90e-01 0.1640 -0.023200 -0.041000 -0.098500 0.076600 -0.094700 8.07e-01 6.66e-01 3.00e-01 4.20e-01 3.19e-01
NUCLEAR IMPORT OF REV PROTEIN 32 6.77e-01 7.46e-01 0.1630 -0.153000 -0.048800 -0.012900 -0.025600 -0.013100 1.35e-01 6.33e-01 8.99e-01 8.02e-01 8.98e-01
CELL CELL COMMUNICATION 103 5.72e-03 2.00e-02 0.1630 -0.105000 -0.088000 0.058500 0.052000 0.042200 6.62e-02 1.23e-01 3.05e-01 3.63e-01 4.59e-01
ESR MEDIATED SIGNALING 160 8.24e-02 1.64e-01 0.1630 -0.102000 -0.063000 -0.039900 -0.005800 -0.103000 2.66e-02 1.70e-01 3.84e-01 8.99e-01 2.45e-02
SIGNALING BY FGFR2 61 2.13e-01 3.29e-01 0.1630 0.072800 0.122000 -0.016900 0.029800 -0.071400 3.26e-01 9.96e-02 8.20e-01 6.87e-01 3.35e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 523 3.40e-04 1.86e-03 0.1620 -0.060900 -0.043200 -0.082700 -0.016800 -0.117000 1.76e-02 9.25e-02 1.28e-03 5.14e-01 5.23e-06
ORGANELLE BIOGENESIS AND MAINTENANCE 281 1.10e-03 4.89e-03 0.1620 0.084900 0.099800 -0.001580 0.087500 0.037900 1.46e-02 4.06e-03 9.64e-01 1.18e-02 2.75e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 22 7.30e-01 7.89e-01 0.1610 -0.102000 -0.065300 0.031400 -0.041600 -0.092700 4.07e-01 5.96e-01 7.99e-01 7.36e-01 4.52e-01
EPH EPHRIN SIGNALING 90 1.53e-02 4.58e-02 0.1610 -0.064100 -0.039400 0.065300 0.122000 -0.035200 2.93e-01 5.19e-01 2.85e-01 4.63e-02 5.64e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 81 1.62e-01 2.71e-01 0.1610 -0.001690 -0.081200 0.021200 0.137000 -0.001270 9.79e-01 2.07e-01 7.42e-01 3.33e-02 9.84e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 9.66e-01 9.74e-01 0.1600 0.060900 0.027500 0.130000 0.053300 0.036300 6.93e-01 8.59e-01 4.01e-01 7.30e-01 8.14e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 6.17e-01 7.00e-01 0.1590 -0.146000 -0.040200 -0.001480 -0.024800 -0.040500 1.40e-01 6.85e-01 9.88e-01 8.03e-01 6.83e-01
RAB REGULATION OF TRAFFICKING 118 3.80e-02 9.20e-02 0.1590 0.019900 -0.046600 0.054300 0.126000 -0.061400 7.10e-01 3.83e-01 3.08e-01 1.81e-02 2.50e-01
REGULATED PROTEOLYSIS OF P75NTR 12 9.36e-01 9.50e-01 0.1590 -0.028600 0.071300 0.101000 0.063000 0.070700 8.64e-01 6.69e-01 5.43e-01 7.05e-01 6.72e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 3.55e-01 4.78e-01 0.1580 -0.021800 0.012500 0.118000 0.011800 0.102000 7.72e-01 8.68e-01 1.18e-01 8.76e-01 1.77e-01
MYD88 INDEPENDENT TLR4 CASCADE 92 2.21e-01 3.36e-01 0.1570 -0.016000 -0.049500 -0.008210 0.102000 -0.107000 7.91e-01 4.12e-01 8.92e-01 9.03e-02 7.50e-02
RNA POLYMERASE III TRANSCRIPTION 41 3.65e-01 4.86e-01 0.1570 0.088900 0.076500 -0.018800 -0.093100 -0.043600 3.25e-01 3.97e-01 8.35e-01 3.02e-01 6.29e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 8.80e-01 9.05e-01 0.1570 -0.044800 -0.034900 -0.027900 0.138000 -0.038800 7.16e-01 7.77e-01 8.21e-01 2.62e-01 7.53e-01
RHO GTPASE CYCLE 420 2.20e-08 2.83e-07 0.1570 -0.062600 0.058400 0.073300 0.015800 0.108000 2.83e-02 4.10e-02 1.02e-02 5.80e-01 1.61e-04
METABOLISM OF VITAMINS AND COFACTORS 146 1.05e-01 1.96e-01 0.1560 0.091000 0.026200 0.075100 0.096800 -0.022700 5.80e-02 5.85e-01 1.18e-01 4.39e-02 6.36e-01
SIGNALING BY FGFR3 33 6.33e-01 7.12e-01 0.1560 -0.022100 0.077700 -0.011000 0.133000 -0.013200 8.27e-01 4.40e-01 9.13e-01 1.87e-01 8.96e-01
INFECTIOUS DISEASE 711 5.16e-13 1.39e-11 0.1560 0.044700 0.040300 -0.039500 0.052900 -0.128000 4.35e-02 6.89e-02 7.48e-02 1.68e-02 6.86e-09
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 73 3.16e-01 4.38e-01 0.1550 -0.005440 -0.007730 -0.111000 0.098600 -0.044500 9.36e-01 9.09e-01 1.02e-01 1.46e-01 5.11e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 2.67e-01 3.87e-01 0.1530 -0.048000 0.006930 0.121000 0.075400 0.025000 5.95e-01 9.39e-01 1.79e-01 4.04e-01 7.82e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 135 1.20e-01 2.15e-01 0.1530 0.036900 -0.006840 -0.067200 0.093500 -0.093100 4.60e-01 8.91e-01 1.78e-01 6.10e-02 6.20e-02
SUMOYLATION 158 2.95e-01 4.17e-01 0.1530 -0.100000 -0.052300 -0.067100 -0.073400 -0.023800 2.97e-02 2.57e-01 1.46e-01 1.12e-01 6.05e-01
RHO GTPASES ACTIVATE PKNS 46 6.25e-01 7.07e-01 0.1520 -0.028300 -0.011700 -0.044100 0.013100 -0.142000 7.40e-01 8.90e-01 6.05e-01 8.78e-01 9.54e-02
VITAMIN B5 PANTOTHENATE METABOLISM 14 9.65e-01 9.74e-01 0.1520 0.011600 -0.013100 -0.005190 0.148000 -0.032500 9.40e-01 9.32e-01 9.73e-01 3.38e-01 8.33e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 5.23e-01 6.20e-01 0.1520 0.044900 0.027400 0.091100 0.030600 -0.106000 6.81e-01 8.02e-01 4.04e-01 7.79e-01 3.34e-01
VIRAL MESSENGER RNA SYNTHESIS 42 4.79e-01 5.82e-01 0.1520 -0.031300 -0.018400 0.053300 -0.129000 -0.048600 7.26e-01 8.36e-01 5.50e-01 1.49e-01 5.86e-01
SARS COV INFECTIONS 139 8.39e-02 1.66e-01 0.1520 0.063800 0.026000 0.022200 0.111000 -0.073200 1.95e-01 5.97e-01 6.52e-01 2.38e-02 1.37e-01
SIGNALING BY ERBB2 47 6.07e-01 6.90e-01 0.1510 -0.122000 0.004260 -0.054600 0.010400 -0.069200 1.46e-01 9.60e-01 5.18e-01 9.02e-01 4.12e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 8.83e-01 9.07e-01 0.1510 0.003360 -0.026300 0.052400 -0.138000 0.020200 9.78e-01 8.31e-01 6.71e-01 2.63e-01 8.69e-01
ION CHANNEL TRANSPORT 135 1.83e-02 5.30e-02 0.1510 -0.043900 -0.034800 0.084200 -0.005610 0.112000 3.79e-01 4.86e-01 9.15e-02 9.11e-01 2.51e-02
TOLL LIKE RECEPTOR CASCADES 136 8.45e-02 1.67e-01 0.1500 -0.058600 -0.036900 -0.023400 0.066200 -0.114000 2.39e-01 4.58e-01 6.38e-01 1.83e-01 2.23e-02
RND1 GTPASE CYCLE 37 6.06e-01 6.90e-01 0.1500 -0.090400 -0.102000 -0.024400 0.021100 0.054500 3.42e-01 2.83e-01 7.97e-01 8.25e-01 5.66e-01
RHOG GTPASE CYCLE 73 5.43e-02 1.22e-01 0.1490 -0.094400 0.071100 0.038600 0.074600 0.034800 1.63e-01 2.94e-01 5.68e-01 2.70e-01 6.07e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.87e-01 7.53e-01 0.1490 -0.064200 -0.004770 0.062800 -0.093500 0.073600 4.72e-01 9.57e-01 4.82e-01 2.95e-01 4.09e-01
CIRCADIAN CLOCK 68 2.65e-01 3.87e-01 0.1490 -0.133000 -0.029700 0.015100 -0.047700 0.035000 5.86e-02 6.72e-01 8.29e-01 4.96e-01 6.18e-01
SIGNALING BY FGFR4 31 7.70e-01 8.22e-01 0.1480 -0.026400 0.026800 -0.039800 0.137000 -0.019500 7.99e-01 7.96e-01 7.02e-01 1.88e-01 8.51e-01
UB SPECIFIC PROCESSING PROTEASES 165 3.65e-02 9.01e-02 0.1480 0.056500 -0.007270 -0.070600 0.075700 -0.089600 2.11e-01 8.72e-01 1.18e-01 9.38e-02 4.73e-02
NUCLEAR SIGNALING BY ERBB4 30 9.33e-01 9.48e-01 0.1480 0.068600 0.070500 0.044400 0.099600 0.017900 5.16e-01 5.04e-01 6.74e-01 3.45e-01 8.65e-01
DNA DOUBLE STRAND BREAK REPAIR 134 9.86e-02 1.89e-01 0.1480 -0.033800 -0.040100 -0.010800 -0.125000 -0.057000 5.00e-01 4.24e-01 8.30e-01 1.24e-02 2.55e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.35e-01 9.50e-01 0.1470 -0.019500 0.012000 0.003730 0.005260 -0.145000 9.11e-01 9.45e-01 9.83e-01 9.76e-01 4.05e-01
RNA POLYMERASE II TRANSCRIPTION 1069 1.17e-05 9.15e-05 0.1470 -0.077300 -0.048100 -0.075700 -0.047200 -0.072900 2.36e-05 8.56e-03 3.45e-05 9.77e-03 6.64e-05
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 9.08e-01 9.26e-01 0.1460 -0.103000 0.048300 -0.080400 -0.043900 -0.002950 4.36e-01 7.15e-01 5.44e-01 7.40e-01 9.82e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 42 3.60e-01 4.83e-01 0.1460 -0.006040 -0.072500 0.124000 -0.024100 0.010900 9.46e-01 4.16e-01 1.65e-01 7.87e-01 9.03e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 60 1.71e-01 2.81e-01 0.1460 -0.008530 -0.028900 0.072400 -0.100000 -0.071500 9.09e-01 6.98e-01 3.32e-01 1.79e-01 3.38e-01
HATS ACETYLATE HISTONES 90 1.76e-01 2.88e-01 0.1440 0.008660 -0.038200 0.111000 -0.069300 0.045700 8.87e-01 5.32e-01 6.97e-02 2.56e-01 4.54e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 6.99e-01 7.63e-01 0.1440 -0.026400 0.026200 0.094000 -0.042800 0.092600 7.52e-01 7.54e-01 2.60e-01 6.08e-01 2.67e-01
METABOLISM OF STEROIDS 110 5.13e-02 1.17e-01 0.1420 0.060100 0.000844 -0.045200 0.108000 0.053600 2.76e-01 9.88e-01 4.13e-01 5.15e-02 3.32e-01
VISUAL PHOTOTRANSDUCTION 55 3.84e-01 5.00e-01 0.1410 0.088500 -0.093900 0.009020 0.054900 -0.009990 2.56e-01 2.28e-01 9.08e-01 4.81e-01 8.98e-01
MAP2K AND MAPK ACTIVATION 36 4.89e-01 5.91e-01 0.1410 -0.056200 0.026000 0.104000 0.052500 0.049800 5.60e-01 7.87e-01 2.82e-01 5.86e-01 6.05e-01
NUCLEAR ENVELOPE BREAKDOWN 47 4.76e-01 5.79e-01 0.1400 -0.125000 -0.053200 0.006870 0.028700 -0.012900 1.37e-01 5.28e-01 9.35e-01 7.34e-01 8.78e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 6.36e-01 7.13e-01 0.1400 -0.136000 -0.009230 -0.015700 0.023800 0.011400 1.69e-01 9.26e-01 8.74e-01 8.10e-01 9.09e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 40 5.59e-01 6.50e-01 0.1400 0.048100 -0.097400 0.023900 0.065600 0.053300 5.99e-01 2.86e-01 7.94e-01 4.73e-01 5.60e-01
DNA REPAIR 288 1.16e-04 7.12e-04 0.1390 0.027000 -0.051100 -0.016200 -0.073200 -0.102000 4.31e-01 1.36e-01 6.38e-01 3.31e-02 2.96e-03
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 9.78e-01 9.83e-01 0.1390 0.095000 0.025200 0.086500 -0.041000 -0.022500 6.03e-01 8.90e-01 6.36e-01 8.22e-01 9.02e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 99 1.82e-01 2.93e-01 0.1380 0.033200 0.027100 0.088600 0.093800 -0.023700 5.68e-01 6.41e-01 1.28e-01 1.07e-01 6.84e-01
METABOLISM OF LIPIDS 600 3.99e-07 4.28e-06 0.1370 0.008240 -0.017400 0.025700 0.126000 -0.045900 7.32e-01 4.69e-01 2.84e-01 1.72e-07 5.59e-02
GENE SILENCING BY RNA 80 4.00e-01 5.15e-01 0.1360 -0.029900 -0.008040 0.039200 -0.127000 -0.003480 6.44e-01 9.01e-01 5.45e-01 5.01e-02 9.57e-01
ONCOGENIC MAPK SIGNALING 76 1.84e-01 2.95e-01 0.1360 -0.040600 -0.012800 0.076600 0.077600 0.068600 5.41e-01 8.47e-01 2.49e-01 2.42e-01 3.01e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 4.50e-01 5.63e-01 0.1350 -0.023400 -0.006170 -0.082100 -0.069700 -0.078400 7.06e-01 9.21e-01 1.86e-01 2.61e-01 2.07e-01
RHO GTPASE EFFECTORS 241 8.29e-04 3.88e-03 0.1350 -0.032300 0.037000 0.015400 0.111000 -0.055100 3.89e-01 3.23e-01 6.81e-01 2.95e-03 1.41e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 41 8.24e-01 8.65e-01 0.1340 -0.024800 -0.058700 -0.024600 -0.008280 -0.115000 7.83e-01 5.16e-01 7.85e-01 9.27e-01 2.01e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 57 3.86e-01 5.00e-01 0.1340 -0.132000 -0.012300 0.002960 -0.005470 -0.016000 8.41e-02 8.72e-01 9.69e-01 9.43e-01 8.34e-01
SIGNALING BY FGFR IN DISEASE 54 6.49e-01 7.26e-01 0.1340 -0.040000 0.034400 -0.076400 -0.055800 -0.078600 6.11e-01 6.62e-01 3.32e-01 4.79e-01 3.18e-01
RHOD GTPASE CYCLE 50 4.21e-01 5.32e-01 0.1340 -0.092600 0.009370 -0.058000 0.056900 0.051100 2.58e-01 9.09e-01 4.78e-01 4.87e-01 5.32e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 175 1.29e-02 3.99e-02 0.1330 0.044900 0.061400 0.045000 -0.091600 -0.039500 3.06e-01 1.62e-01 3.05e-01 3.68e-02 3.68e-01
SIGNALING BY INTERLEUKINS 335 1.86e-03 7.89e-03 0.1330 0.023600 0.035900 -0.048700 0.081900 -0.082600 4.58e-01 2.60e-01 1.26e-01 1.02e-02 9.56e-03
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 6.62e-01 7.34e-01 0.1330 -0.027800 -0.034300 0.013500 0.124000 -0.001410 7.47e-01 6.91e-01 8.76e-01 1.49e-01 9.87e-01
SIGNALING BY WNT 262 2.44e-02 6.66e-02 0.1320 0.022400 -0.001980 -0.027100 0.088600 -0.091700 5.33e-01 9.56e-01 4.51e-01 1.38e-02 1.08e-02
TRANSCRIPTIONAL REGULATION BY VENTX 35 7.73e-01 8.24e-01 0.1310 0.037000 -0.063200 0.076900 -0.049100 0.058500 7.05e-01 5.18e-01 4.31e-01 6.15e-01 5.49e-01
REGULATION OF PTEN GENE TRANSCRIPTION 57 4.94e-01 5.95e-01 0.1310 0.003770 0.075100 0.075100 0.075600 -0.007980 9.61e-01 3.27e-01 3.27e-01 3.24e-01 9.17e-01
POTENTIAL THERAPEUTICS FOR SARS 76 7.38e-01 7.97e-01 0.1300 0.051700 0.094400 0.062900 0.034100 0.016200 4.36e-01 1.55e-01 3.43e-01 6.07e-01 8.07e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 33 7.42e-01 7.99e-01 0.1300 0.001250 0.027200 -0.062500 0.106000 0.029700 9.90e-01 7.87e-01 5.34e-01 2.91e-01 7.68e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.71e-01 9.79e-01 0.1290 -0.002920 0.105000 -0.007890 0.058800 -0.045000 9.87e-01 5.45e-01 9.64e-01 7.36e-01 7.96e-01
SIGNALING BY FGFR 70 3.80e-01 4.99e-01 0.1280 0.031200 0.089300 -0.016100 0.040400 -0.075100 6.52e-01 1.97e-01 8.16e-01 5.59e-01 2.78e-01
MEIOTIC SYNAPSIS 38 6.28e-01 7.09e-01 0.1280 0.024100 0.084100 -0.009910 -0.045100 -0.081200 7.97e-01 3.70e-01 9.16e-01 6.31e-01 3.87e-01
SNRNP ASSEMBLY 51 7.92e-01 8.38e-01 0.1270 -0.024100 -0.010900 -0.050800 -0.009420 -0.113000 7.66e-01 8.93e-01 5.30e-01 9.07e-01 1.62e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 90 1.90e-01 3.02e-01 0.1270 -0.064200 -0.059200 0.026100 0.029900 -0.083200 2.93e-01 3.32e-01 6.69e-01 6.24e-01 1.73e-01
OXIDATIVE STRESS INDUCED SENESCENCE 77 3.22e-01 4.43e-01 0.1270 0.022900 0.023700 0.118000 -0.034400 0.002710 7.29e-01 7.19e-01 7.46e-02 6.02e-01 9.67e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 1.18e-01 2.13e-01 0.1270 -0.090100 0.074400 -0.021400 0.042800 0.011200 1.42e-01 2.25e-01 7.27e-01 4.85e-01 8.56e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 7.44e-01 8.01e-01 0.1260 -0.103000 -0.003170 -0.044800 0.052300 -0.020400 2.48e-01 9.72e-01 6.15e-01 5.57e-01 8.19e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 3.16e-01 4.38e-01 0.1250 -0.050200 -0.021000 0.080700 0.064500 0.045000 5.02e-01 7.79e-01 2.80e-01 3.88e-01 5.47e-01
SIGNALING BY PTK6 49 5.72e-01 6.61e-01 0.1230 -0.012000 0.058900 0.075600 0.076900 0.000232 8.85e-01 4.76e-01 3.60e-01 3.52e-01 9.98e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 6.33e-01 7.12e-01 0.1170 -0.086700 0.049000 0.018300 0.021900 0.054800 3.37e-01 5.87e-01 8.39e-01 8.08e-01 5.44e-01
MITOTIC PROMETAPHASE 173 6.14e-02 1.34e-01 0.1170 -0.017900 0.062500 -0.070800 0.055100 -0.038200 6.85e-01 1.56e-01 1.09e-01 2.12e-01 3.87e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 617 1.25e-06 1.18e-05 0.1160 -0.028100 0.054000 0.062400 0.050000 0.058800 2.36e-01 2.27e-02 8.50e-03 3.48e-02 1.32e-02
HEMOSTASIS 461 1.88e-06 1.69e-05 0.1160 -0.038700 0.028600 0.047400 0.093900 0.010500 1.56e-01 2.95e-01 8.22e-02 5.79e-04 7.00e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 6.38e-01 7.15e-01 0.1160 0.010200 0.094000 0.003750 -0.007270 0.066700 8.77e-01 1.51e-01 9.54e-01 9.12e-01 3.09e-01
PI3K AKT SIGNALING IN CANCER 84 1.29e-01 2.30e-01 0.1160 -0.086100 -0.028900 0.059200 0.040700 0.003810 1.73e-01 6.47e-01 3.48e-01 5.19e-01 9.52e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 4.66e-01 5.73e-01 0.1130 0.014500 0.101000 -0.022700 -0.030600 0.031500 8.18e-01 1.10e-01 7.19e-01 6.29e-01 6.18e-01
SIGNALING BY NUCLEAR RECEPTORS 214 1.98e-01 3.11e-01 0.1120 -0.069100 -0.038600 -0.024400 0.024800 -0.071800 8.21e-02 3.32e-01 5.40e-01 5.32e-01 7.09e-02
DOWNSTREAM SIGNAL TRANSDUCTION 29 8.66e-01 8.94e-01 0.1120 -0.021100 -0.016300 0.021400 0.052500 0.092600 8.44e-01 8.79e-01 8.42e-01 6.25e-01 3.88e-01
MITOCHONDRIAL BIOGENESIS 92 2.87e-01 4.09e-01 0.1120 -0.059600 0.057900 0.001990 -0.056300 -0.049000 3.23e-01 3.38e-01 9.74e-01 3.51e-01 4.17e-01
AURKA ACTIVATION BY TPX2 71 6.64e-01 7.36e-01 0.1110 -0.008080 0.088200 -0.006140 -0.030500 0.060000 9.06e-01 1.99e-01 9.29e-01 6.57e-01 3.82e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 105 2.47e-01 3.68e-01 0.1090 -0.027300 -0.018500 0.051900 0.086200 0.027700 6.29e-01 7.44e-01 3.58e-01 1.27e-01 6.24e-01
LEISHMANIA INFECTION 182 1.27e-02 3.95e-02 0.1090 -0.082600 -0.035800 0.037500 0.043900 -0.019900 5.51e-02 4.06e-01 3.83e-01 3.08e-01 6.43e-01
DEUBIQUITINATION 238 2.54e-01 3.75e-01 0.1080 0.005670 -0.015900 -0.053300 0.047600 -0.079100 8.81e-01 6.73e-01 1.57e-01 2.07e-01 3.60e-02
BASIGIN INTERACTIONS 22 9.54e-01 9.66e-01 0.1070 -0.056000 -0.074400 0.018400 0.019300 -0.045700 6.49e-01 5.46e-01 8.81e-01 8.75e-01 7.11e-01
SENSORY PERCEPTION 133 5.86e-01 6.72e-01 0.1060 0.023700 0.018500 0.031200 -0.052000 0.081000 6.37e-01 7.13e-01 5.34e-01 3.01e-01 1.07e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 4.52e-01 5.64e-01 0.1050 -0.037600 -0.050300 0.018500 0.043000 -0.070300 5.33e-01 4.05e-01 7.59e-01 4.77e-01 2.44e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 7.06e-01 7.68e-01 0.1040 -0.003220 -0.017400 0.025700 -0.091100 -0.037900 9.65e-01 8.14e-01 7.29e-01 2.19e-01 6.08e-01
TRANSPORT OF SMALL MOLECULES 551 1.32e-04 7.96e-04 0.1020 -0.013100 -0.044700 0.031700 0.085000 0.005180 6.01e-01 7.39e-02 2.06e-01 6.87e-04 8.36e-01
TRNA PROCESSING 105 2.98e-01 4.21e-01 0.1000 0.005420 0.026800 -0.000948 -0.019100 -0.094800 9.24e-01 6.35e-01 9.87e-01 7.35e-01 9.36e-02
NERVOUS SYSTEM DEVELOPMENT 542 1.18e-02 3.70e-02 0.0985 0.022100 0.085900 0.041200 -0.003820 0.011200 3.82e-01 6.66e-04 1.02e-01 8.80e-01 6.57e-01
DOWNREGULATION OF ERBB2 SIGNALING 27 9.37e-01 9.50e-01 0.0976 -0.010300 0.070700 0.045900 -0.046100 -0.013400 9.26e-01 5.25e-01 6.80e-01 6.79e-01 9.04e-01
DEVELOPMENTAL BIOLOGY 793 1.83e-03 7.79e-03 0.0934 0.006150 0.062900 0.061600 -0.017600 0.024800 7.70e-01 2.79e-03 3.40e-03 4.03e-01 2.38e-01
SIGNALING BY NOTCH 186 4.63e-01 5.71e-01 0.0924 0.064000 0.035100 0.050800 0.018100 -0.017500 1.33e-01 4.10e-01 2.33e-01 6.71e-01 6.82e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 451 1.25e-04 7.63e-04 0.0921 -0.037500 0.016300 0.044500 0.068300 -0.012600 1.74e-01 5.56e-01 1.06e-01 1.33e-02 6.47e-01
CELLULAR SENESCENCE 139 4.07e-01 5.20e-01 0.0875 0.044300 0.002540 0.072200 -0.014400 -0.016100 3.68e-01 9.59e-01 1.42e-01 7.70e-01 7.43e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 7.90e-01 8.38e-01 0.0866 -0.000235 0.013700 -0.077100 0.013800 -0.034200 9.97e-01 8.38e-01 2.52e-01 8.37e-01 6.12e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 275 6.79e-02 1.44e-01 0.0852 -0.023400 0.014600 0.020700 0.073700 -0.025400 5.05e-01 6.77e-01 5.55e-01 3.60e-02 4.69e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 28 9.96e-01 9.97e-01 0.0852 -0.049900 -0.044000 -0.022500 -0.004530 -0.048000 6.48e-01 6.87e-01 8.37e-01 9.67e-01 6.60e-01
MAPK FAMILY SIGNALING CASCADES 282 5.82e-02 1.29e-01 0.0826 0.001310 0.040800 0.048900 0.045800 -0.025900 9.70e-01 2.40e-01 1.59e-01 1.87e-01 4.55e-01
TRANSCRIPTIONAL REGULATION BY TP53 338 1.41e-01 2.44e-01 0.0824 -0.008750 -0.009840 -0.021700 -0.023500 -0.074800 7.83e-01 7.57e-01 4.94e-01 4.59e-01 1.84e-02
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 51 8.57e-01 8.90e-01 0.0824 0.048700 0.033700 -0.014000 -0.051700 -0.020000 5.47e-01 6.77e-01 8.62e-01 5.23e-01 8.04e-01
REGULATION OF SIGNALING BY CBL 22 9.78e-01 9.83e-01 0.0775 -0.048700 0.037000 -0.025400 0.028800 0.028000 6.93e-01 7.64e-01 8.37e-01 8.15e-01 8.20e-01
SURFACTANT METABOLISM 16 9.98e-01 9.98e-01 0.0739 0.063200 0.020000 0.019700 0.021600 -0.014600 6.62e-01 8.90e-01 8.91e-01 8.81e-01 9.19e-01
NOD1 2 SIGNALING PATHWAY 34 9.93e-01 9.96e-01 0.0729 -0.001640 0.054900 0.034500 -0.012300 0.031000 9.87e-01 5.80e-01 7.28e-01 9.01e-01 7.55e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 9.95e-01 9.97e-01 0.0652 -0.043800 -0.022000 -0.004420 -0.035700 0.023500 6.73e-01 8.32e-01 9.66e-01 7.31e-01 8.21e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 359 3.89e-01 5.03e-01 0.0620 -0.004360 -0.002910 0.011600 0.058200 -0.017100 8.87e-01 9.25e-01 7.06e-01 5.91e-02 5.80e-01
DNA DOUBLE STRAND BREAK RESPONSE 51 9.98e-01 9.98e-01 0.0365 0.022400 0.000633 0.002510 0.011000 0.026500 7.82e-01 9.94e-01 9.75e-01 8.92e-01 7.43e-01
REGULATION OF TP53 ACTIVITY 148 9.92e-01 9.96e-01 0.0336 0.004020 0.025100 0.012600 0.016700 0.006560 9.33e-01 5.98e-01 7.91e-01 7.26e-01 8.91e-01


Detailed Gene set reports


FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 1.78e-10
p.adjustMANOVA 3.16e-09
s.dist 1.01
s.hyp 0.582
s.amy 0.156
s.hip 0.154
s.pag 0.695
s.ni -0.383
p.hyp 1.11e-05
p.amy 0.239
p.hip 0.244
p.pag 1.53e-07
p.ni 0.00385 


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Top 20 genes
Gene pag hyp
Tubb2a 7623 7422
Tuba1b 7377 7288
Tubb4b 7140 7429
Cct5 6862 7361
Tuba1a 6615 7304
Tubb4a 7042 6675
Cct3 6697 6694
Tubb2b 7029 5998
Tubb3 5442 6704
Tuba4a 6754 4780
Cct7 4503 6725
Cct4 5832 3515
Tubb6 1669 6888
Tuba1c 4165 2735
Cct2 3551 580

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Cct2 580 -1968 -5946 3551 -6409
Cct3 6694 2897 -654 6697 -2598
Cct4 3515 41 -6868 5832 -6863
Cct5 7361 1553 1983 6862 -5371
Cct6a -1912 -4653 -7244 7630 -7376
Cct7 6725 -2976 -878 4503 -5353
Cct8 -2034 -5 -7370 6059 -5002
Tcp1 -2953 -5257 -7114 6208 -6815
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873



TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
metric value
setSize 13
pMANOVA 1.73e-05
p.adjustMANOVA 0.000128
s.dist 0.973
s.hyp 0.593
s.amy 0.317
s.hip 0.449
s.pag 0.523
s.ni -0.137
p.hyp 0.000212
p.amy 0.0481
p.hip 0.00509
p.pag 0.00109
p.ni 0.392 


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Top 20 genes
Gene hyp pag
Tubb2a 7422 7623
Tuba1b 7288 7377
Tubb4b 7429 7140
Tuba1a 7304 6615
Tubb4a 6675 7042
Tubb2b 5998 7029
Tubb3 6704 5442
Tuba4a 4780 6754
Tubb6 6888 1669
Tuba1c 2735 4165

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Gja1 -3985 -680 -6146 4746 -201
Gjb2 -3910 1770 -6718 -7780 -2802
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873



POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
metric value
setSize 17
pMANOVA 1.1e-06
p.adjustMANOVA 1.04e-05
s.dist 0.941
s.hyp 0.63
s.amy 0.316
s.hip 0.503
s.pag 0.359
s.ni -0.0845
p.hyp 6.79e-06
p.amy 0.0239
p.hip 0.00033
p.pag 0.0104
p.ni 0.547 


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Top 20 genes
Gene hyp hip
Tubb2a 7422 7378
Tubb4b 7429 7348
Tubb4a 6675 7975
Tubb3 6704 7359
Tubb6 6888 6359
Tuba1b 7288 5655
Arl2 5877 6385
Tbcd 4677 7735
Tubb2b 5998 5133
Tuba1a 7304 4047
Tuba4a 4780 4170
Tbcb 6490 3068
Tuba1c 2735 6857
Tuba8 4395 955
Tbcc 2265 1304

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Arl2 5877 4518 6385 -1463 1287
Tbca -939 3779 -6101 -4618 -4580
Tbcb 6490 4365 3068 -1523 -2418
Tbcc 2265 -137 1304 -2713 -1290
Tbcd 4677 2099 7735 6597 7792
Tbce -2899 -5025 -2445 -5261 -446
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873



ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY
metric value
setSize 10
pMANOVA 0.000192
p.adjustMANOVA 0.0011
s.dist 0.864
s.hyp -0.0884
s.amy 0.208
s.hip 0.457
s.pag 0.162
s.ni 0.678
p.hyp 0.628
p.amy 0.254
p.hip 0.0124
p.pag 0.376
p.ni 0.000203 


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Top 20 genes
Gene ni hip
Adcy6 7847 7469
Adcy4 7836 7066
Adcy5 6598 6818
Adcy3 4849 5813
Adcy1 2893 5872
Adcy9 4860 3492
Gnal 4054 2169
Adcy2 5372 1614
Adcy7 4743 460

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Adcy1 -7887 -4314 5872 -6445 2893
Adcy2 -1095 1803 1614 4119 5372
Adcy3 6013 3346 5813 5037 4849
Adcy4 4857 7500 7066 6302 7836
Adcy5 -905 157 6818 2805 6598
Adcy6 7158 5232 7469 -1829 7847
Adcy7 593 3636 460 2163 4743
Adcy8 -6076 635 -1390 -413 6364
Adcy9 -3574 -3676 3492 -3784 4860
Gnal -7344 -1598 2169 3938 4054



CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS
metric value
setSize 13
pMANOVA 0.0178
p.adjustMANOVA 0.0516
s.dist 0.832
s.hyp 0.335
s.amy 0.401
s.hip 0.567
s.pag 0.0344
s.ni 0.311
p.hyp 0.0365
p.amy 0.0122
p.hip 0.000399
p.pag 0.83
p.ni 0.0521 


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Top 20 genes
Gene hip amy
Loxl3 7268 6685
Bmp1 4855 7404
Col4a2 5826 5369
Pcolce 6924 4477
Col1a2 2280 7093
Col1a1 5803 2462
Col4a5 3915 2356
Loxl1 7868 1168
Pxdn 6953 960
Col4a3 3517 1751
Tll2 4390 1102

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Bmp1 896 7404 4855 -1919 5918
Col1a1 570 2462 5803 -1757 5232
Col1a2 7095 7093 2280 3998 4115
Col4a1 -1186 -800 5234 -4564 3798
Col4a2 1222 5369 5826 -1887 5684
Col4a3 1866 1751 3517 -3786 2012
Col4a5 3794 2356 3915 4818 3478
Loxl1 5787 1168 7868 -5513 -5783
Loxl3 7215 6685 7268 7637 7575
Pcolce 4388 4477 6924 5338 -3893
Pxdn 2248 960 6953 -2123 7694
Tll1 -3085 -3527 -2225 -819 -2351
Tll2 2225 1102 4390 2871 578



MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
metric value
setSize 10
pMANOVA 0.0645
p.adjustMANOVA 0.139
s.dist 0.822
s.hyp -0.364
s.amy -0.54
s.hip -0.361
s.pag 0.132
s.ni -0.322
p.hyp 0.0465
p.amy 0.00309
p.hip 0.0481
p.pag 0.468
p.ni 0.0781 


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Top 20 genes
Gene amy hyp
Rap1b -7939 -5635
Rap1a -4971 -6909
Met -7380 -3961
Gab1 -4581 -6091
Dock7 -6455 -4279
Crkl -5216 -4790
Rac1 -6714 -3134
Crk -4914 -2041

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Crk -2041 -4914 -4691 906 -3717
Crkl -4790 -5216 -4027 4759 -88
Dock7 -4279 -6455 -2327 -6779 2058
Gab1 -6091 -4581 2774 -3347 -3111
Grb2 2566 -3058 -1034 -415 -2928
Met -3961 -7380 -4705 1080 -2311
Rac1 -3134 -6714 -4501 5612 -6665
Rap1a -6909 -4971 -7618 1686 -7777
Rap1b -5635 -7939 -7350 7512 -7028
Rapgef1 4132 4427 7846 -1447 7442



SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
metric value
setSize 23
pMANOVA 5.16e-07
p.adjustMANOVA 5.21e-06
s.dist 0.798
s.hyp 0.514
s.amy 0.258
s.hip 0.315
s.pag 0.423
s.ni -0.167
p.hyp 2.01e-05
p.amy 0.0319
p.hip 0.00892
p.pag 0.000449
p.ni 0.165 


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Top 20 genes
Gene hyp pag
Tubb2a 7422 7623
Tuba1b 7288 7377
Tubb4b 7429 7140
Tuba1a 7304 6615
Tubb4a 6675 7042
Chmp7 6341 6698
Tubb2b 5998 7029
Chmp4b 7029 5631
Tubb3 6704 5442
Tuba4a 4780 6754
Vps4a 4169 6793
Tubb6 6888 1669
Tuba1c 2735 4165
Chmp6 5715 1585

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Cc2d1b 3915 5136 5559 -4754 3543
Chmp2a 3517 1431 -707 -2408 -2931
Chmp2b -7789 -7732 -6241 5923 -7646
Chmp3 -104 -2319 -5618 6654 -5642
Chmp4b 7029 5859 4566 5631 -1597
Chmp4c -1949 -943 70 -7512 3111
Chmp6 5715 3844 4061 1585 -3259
Chmp7 6341 3003 2739 6698 698
Ist1 -1695 3822 -179 -3968 1580
Lemd2 7707 4871 8100 -966 6947
Spast -3442 -7391 -7288 5523 -6564
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873
Vps4a 4169 2186 -3659 6793 -6180



CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
metric value
setSize 11
pMANOVA 0.026
p.adjustMANOVA 0.069
s.dist 0.79
s.hyp -0.127
s.amy -0.317
s.hip -0.438
s.pag 0.394
s.ni -0.4
p.hyp 0.467
p.amy 0.0687
p.hip 0.0118
p.pag 0.0236
p.ni 0.0218 


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Top 20 genes
Gene hip ni
Cdc42 -7563 -7442
Pak1 -6353 -6494
Rac1 -4501 -6665
Pak2 -6409 -4422
Pak3 -7382 -3528
Cd86 -3110 -5661
Grb2 -1034 -2928

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Cd80 -1468 4737 -2649 -4249 5313
Cd86 -1932 -6582 -3110 6008 -5661
Cdc42 -6529 -6426 -7563 3373 -7442
Fyn 2573 -3784 999 4093 -703
Grb2 2566 -3058 -1034 -415 -2928
Lck 5211 -4960 1273 3043 2200
Pak1 -4617 -6874 -6353 5947 -6494
Pak2 -2890 -2147 -6409 5492 -4422
Pak3 -3040 -3484 -7382 3322 -3528
Rac1 -3134 -6714 -4501 5612 -6665
Vav1 831 7354 1761 1191 -3015



CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
metric value
setSize 13
pMANOVA 0.0137
p.adjustMANOVA 0.0419
s.dist 0.782
s.hyp 0.388
s.amy 0.437
s.hip 0.457
s.pag -0.16
s.ni 0.19
p.hyp 0.0154
p.amy 0.00643
p.hip 0.00433
p.pag 0.318
p.ni 0.237 


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Top 20 genes
Gene hip amy
Ercc2 8217 7248
Ndor1 7952 7016
Pold1 5662 6361
Ciao3 7173 4790
Ciao2b 3630 7081
Nubp1 7313 3266
Rtel1 4991 4561
Ciapin1 4087 4801

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Abcb7 -6902 -1194 -7158 2730 -3955
Brip1 4235 4003 -4332 -5102 9
Ciao1 6308 -3352 1790 7141 -5953
Ciao2b 2562 7081 3630 -5701 3188
Ciao3 4214 4790 7173 548 445
Ciapin1 7500 4801 4087 4769 -514
Ercc2 6355 7248 8217 340 7724
Mms19 3143 -1503 7278 -6637 5436
Ndor1 -4845 7016 7952 -4229 4919
Nubp1 7201 3266 7313 -3233 4014
Nubp2 3675 -2935 4631 1946 -1228
Pold1 4855 6361 5662 -5364 3650
Rtel1 223 4561 4991 -4994 3757



ACTIVATION OF RAC1

ACTIVATION OF RAC1
metric value
setSize 13
pMANOVA 0.0213
p.adjustMANOVA 0.0597
s.dist 0.759
s.hyp -0.223
s.amy -0.501
s.hip -0.374
s.pag 0.229
s.ni -0.288
p.hyp 0.165
p.amy 0.00176
p.hip 0.0195
p.pag 0.153
p.ni 0.072 


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Top 20 genes
Gene amy hip
Slit2 -8293 -5353
Pak1 -6874 -6353
Pak5 -4972 -6835
Rac1 -6714 -4501
Sos2 -5946 -5072
Sos1 -5636 -4810
Pak3 -3484 -7382
Pak2 -2147 -6409
Nck1 -502 -6084

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Nck1 -2501 -502 -6084 3605 -6055
Nck2 5982 -1039 5746 407 -1097
Pak1 -4617 -6874 -6353 5947 -6494
Pak2 -2890 -2147 -6409 5492 -4422
Pak3 -3040 -3484 -7382 3322 -3528
Pak4 4696 -1807 8000 -3179 6441
Pak5 -7485 -4972 -6835 -3072 -6762
Pak6 3743 -2579 3353 767 -2904
Rac1 -3134 -6714 -4501 5612 -6665
Robo1 -7257 -6768 1010 -351 3919
Slit2 198 -8293 -5353 6194 4140
Sos1 -3716 -5636 -4810 933 129
Sos2 -4582 -5946 -5072 -3247 -4595



CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
metric value
setSize 11
pMANOVA 0.0165
p.adjustMANOVA 0.0488
s.dist 0.757
s.hyp -0.377
s.amy -0.437
s.hip -0.385
s.pag 0.27
s.ni -0.138
p.hyp 0.0305
p.amy 0.0121
p.hip 0.0269
p.pag 0.121
p.ni 0.428 


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Top 20 genes
Gene amy hip
Prkacb -8088 -7190
Prkar1a -7566 -6864
Prkar2b -7906 -6487
Creb1 -7239 -7037
Calm1 -6438 -7280
Prkx -6774 -4462

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Adcy1 -7887 -4314 5872 -6445 2893
Adcy8 -6076 635 -1390 -413 6364
Calm1 -7408 -6438 -7280 418 -6179
Creb1 -3971 -7239 -7037 6468 -3711
Prkaca 5015 1685 4122 -1465 2494
Prkacb -3253 -8088 -7190 5202 -4967
Prkar1a -1942 -7566 -6864 6644 -4776
Prkar1b 5079 -518 3121 6501 -496
Prkar2a -141 4104 -2732 1606 1892
Prkar2b -7418 -7906 -6487 3683 -4523
Prkx -6316 -6774 -4462 346 537



GAP JUNCTION ASSEMBLY

GAP JUNCTION ASSEMBLY
metric value
setSize 21
pMANOVA 2.17e-05
p.adjustMANOVA 0.000155
s.dist 0.745
s.hyp 0.438
s.amy 0.226
s.hip 0.319
s.pag 0.439
s.ni -0.133
p.hyp 0.000506
p.amy 0.0729
p.hip 0.0113
p.pag 0.000503
p.ni 0.291 


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Top 20 genes
Gene pag hyp
Tubb2a 7623 7422
Tuba1b 7377 7288
Tubb4b 7140 7429
Tuba1a 6615 7304
Tubb4a 7042 6675
Tubb2b 7029 5998
Gjb6 7099 5438
Tubb3 5442 6704
Tuba4a 6754 4780
Gjd3 5551 4894
Tubb6 1669 6888
Tuba1c 4165 2735

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Gja1 -3985 -680 -6146 4746 -201
Gja4 7101 5227 2549 -1208 829
Gja5 2611 1967 -3332 -6761 2117
Gjb1 -753 -5773 4771 3572 -4132
Gjb2 -3910 1770 -6718 -7780 -2802
Gjb6 5438 7456 -1107 7099 1732
Gjc1 -3832 -1880 -714 2306 1140
Gjc2 -1033 600 6759 1299 -780
Gjd2 -3579 158 -3459 6507 -6934
Gjd3 4894 -5810 3926 5551 -855
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873



SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
metric value
setSize 29
pMANOVA 1.07e-05
p.adjustMANOVA 8.44e-05
s.dist 0.736
s.hyp -0.0487
s.amy -0.222
s.hip -0.402
s.pag 0.323
s.ni -0.474
p.hyp 0.65
p.amy 0.0387
p.hip 0.000179
p.pag 0.00262
p.ni 9.97e-06 


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Top 20 genes
Gene ni hip
Ube2w -7769 -7429
Ube2q2 -7595 -7302
Ube2g1 -7713 -7161
Ube2d1 -7637 -7227
Ube2e1 -7395 -7451
Ube2k -7229 -7493
Ube2e3 -7766 -6925
Ube2b -7365 -7170
Ube2l3 -7255 -6906
Ube2a -7344 -6482
Ube2d2a -7127 -6471
Uchl3 -7459 -4654
Ube2r2 -5061 -3946
Uba6 -3068 -5662
Usp9x -2186 -6651
Rps27a -3739 -3759
Otulin -4121 -2964
Ube2t -3187 -2384

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Cdc34 4684 -121 2727 1984 -4073
Otulin 656 1007 -2964 -5723 -4121
Rps27a 2364 5541 -3759 -441 -3739
Uba1 2167 966 2938 4691 3953
Uba52 4277 3662 1163 -7268 3243
Uba6 -2732 -2906 -5662 7192 -3068
Ubb 6745 2476 5259 1194 -3830
Ubc 2434 2920 4638 4179 3062
Ube2a -1114 -5813 -6482 6543 -7344
Ube2b -5596 -6127 -7170 4715 -7365
Ube2d1 -7770 -7537 -7227 -2126 -7637
Ube2d2a -2195 -6904 -6471 6230 -7127
Ube2e1 -5301 -3421 -7451 3365 -7395
Ube2e3 -3664 -5286 -6925 1596 -7766
Ube2g1 -6357 -4550 -7161 5286 -7713
Ube2g2 1529 -125 5978 2046 2426
Ube2h -4406 -1682 -2691 1257 1996
Ube2k -6854 -5133 -7493 1352 -7229
Ube2l3 -4174 -5684 -6906 5291 -7255
Ube2q2 -6539 -4909 -7302 5922 -7595
Ube2r2 3266 -999 -3946 -221 -5061
Ube2s 6527 22 472 1443 -4239
Ube2t 617 4010 -2384 -4391 -3187
Ube2w -4745 -6866 -7429 5638 -7769
Ube2z 5695 -1985 2138 4964 -1065
Uchl3 6519 -7450 -4654 6279 -7459
Usp5 6658 2325 4526 7211 1968
Usp7 -1878 -842 -2823 446 2633
Usp9x -5594 -6789 -6651 2905 -2186



COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
metric value
setSize 26
pMANOVA 2.19e-08
p.adjustMANOVA 2.83e-07
s.dist 0.733
s.hyp 0.387
s.amy 0.165
s.hip 0.0234
s.pag 0.461
s.ni -0.384
p.hyp 0.000647
p.amy 0.146
p.hip 0.836
p.pag 4.79e-05
p.ni 0.000698 


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Top 20 genes
Gene pag hyp
Tubb2a 7623 7422
Tuba1b 7377 7288
Tubb4b 7140 7429
Cct5 6862 7361
Tuba1a 6615 7304
Tubb4a 7042 6675
Cct3 6697 6694
Tubb2b 7029 5998
Tubb3 5442 6704
Tuba4a 6754 4780
Cct7 4503 6725
Cct4 5832 3515
Tubb6 1669 6888
Tuba1c 4165 2735
Cct2 3551 580
Pfdn1 528 3823

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Actb -6899 -2667 4643 -7405 -2370
Cct2 580 -1968 -5946 3551 -6409
Cct3 6694 2897 -654 6697 -2598
Cct4 3515 41 -6868 5832 -6863
Cct5 7361 1553 1983 6862 -5371
Cct6a -1912 -4653 -7244 7630 -7376
Cct7 6725 -2976 -878 4503 -5353
Cct8 -2034 -5 -7370 6059 -5002
Pfdn1 3823 3350 -1243 528 -3926
Pfdn2 805 7460 -1907 -4447 3548
Pfdn4 -5805 -1254 -6645 4208 -6822
Pfdn5 1570 2304 -881 -2904 -1866
Pfdn6 3588 5919 -2830 -3465 -1380
Tcp1 -2953 -5257 -7114 6208 -6815
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873
Vbp1 -6034 -7329 -7465 2943 -7677



ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
metric value
setSize 12
pMANOVA 0.00225
p.adjustMANOVA 0.00924
s.dist 0.72
s.hyp 0.152
s.amy 0.367
s.hip 0.0551
s.pag 0.59
s.ni 0.0983
p.hyp 0.361
p.amy 0.0279
p.hip 0.741
p.pag 0.000398
p.ni 0.555 


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Top 20 genes
Gene pag amy
Elovl1 7001 7567
Fads1 7715 4915
Fads2 7800 4557
Hsd17b4 6139 4693
Acaa1a 4922 5755
Acot8 3287 5492
Abcd1 1727 5400
Scp2 3531 1526
Elovl5 2444 390

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Abcd1 2432 5400 6875 1727 7056
Acaa1a 7368 5755 7389 4922 4352
Acot8 7355 5492 7789 3287 5045
Acox1 -353 -5054 -2227 5656 -80
Acsl1 -6972 -4000 -2646 2522 541
Elovl1 3245 7567 7017 7001 -2387
Elovl2 -6515 -855 -4915 2425 -5885
Elovl5 -5711 390 -5579 2444 -4346
Fads1 6764 4915 397 7715 5342
Fads2 7324 4557 3486 7800 6393
Hsd17b4 141 4693 -3001 6139 1826
Scp2 -2031 1526 -5647 3531 -6721



CGMP EFFECTS

CGMP EFFECTS
metric value
setSize 15
pMANOVA 0.00371
p.adjustMANOVA 0.0142
s.dist 0.717
s.hyp -0.559
s.amy -0.301
s.hip -0.227
s.pag -0.241
s.ni 0.018
p.hyp 0.000176
p.amy 0.0432
p.hip 0.128
p.pag 0.106
p.ni 0.904 


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Top 20 genes
Gene hyp amy
Pde1a -7442 -8246
Kcnma1 -6803 -7233
Prkg1 -4720 -6307
Pde2a -6948 -3509
Itpr1 -6907 -3526
Pde10a -7598 -2101
Pde11a -3616 -4003
Pde5a -6276 -1788
Kcnmb4 -3552 -2725

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Irag1 -1148 1923 1959 -2080 4564
Itpr1 -6907 -3526 -769 -5929 800
Kcnma1 -6803 -7233 -5593 -4825 4856
Kcnmb1 4221 -5483 -5385 1783 3211
Kcnmb2 -8067 1484 -4902 -2596 -5837
Kcnmb4 -3552 -2725 1374 -2455 -7329
Pde10a -7598 -2101 2750 -4236 4193
Pde11a -3616 -4003 -1820 -6514 4842
Pde1a -7442 -8246 -5233 1502 -2829
Pde1b -7659 303 5422 1395 3840
Pde2a -6948 -3509 5282 525 -759
Pde5a -6276 -1788 -4560 -5347 -3381
Pde9a 2403 -2777 -710 -467 -2498
Prkg1 -4720 -6307 -4239 -2647 -2492
Prkg2 -4448 2290 -6025 1704 3155



REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS
metric value
setSize 11
pMANOVA 0.0186
p.adjustMANOVA 0.0531
s.dist 0.717
s.hyp -0.554
s.amy -0.304
s.hip -0.2
s.pag -0.266
s.ni 0.0577
p.hyp 0.00146
p.amy 0.0804
p.hip 0.252
p.pag 0.127
p.ni 0.74 


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Top 20 genes
Gene hyp amy
Slc8a1 -7678 -8128
Calm1 -7408 -6438
Atp2b4 -7260 -6306
Atp2b1 -7969 -4361
Sri -6321 -3580
Atp2a2 -3964 -5280
Atp2a3 -6674 -982
Atp2b3 -1263 -249

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Atp2a2 -3964 -5280 -2886 1855 1169
Atp2a3 -6674 -982 4469 -5984 -872
Atp2b1 -7969 -4361 -5083 -7906 115
Atp2b2 -6476 386 1726 -6196 3778
Atp2b3 -1263 -249 3464 -3655 3300
Atp2b4 -7260 -6306 -3761 -2566 7223
Calm1 -7408 -6438 -7280 418 -6179
Slc8a1 -7678 -8128 -5963 -3746 -2110
Slc8a2 3851 -936 7582 856 3231
Slc8a3 1347 5032 493 -436 4167
Sri -6321 -3580 -6846 3051 -7168



SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
metric value
setSize 12
pMANOVA 0.0195
p.adjustMANOVA 0.0553
s.dist 0.715
s.hyp -0.11
s.amy -0.152
s.hip -0.527
s.pag 0.0254
s.ni -0.445
p.hyp 0.511
p.amy 0.362
p.hip 0.00159
p.pag 0.879
p.ni 0.0076 


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Top 20 genes
Gene hip ni
Spcs3 -7356 -7245
Spcs2 -7495 -5753
Spcs1 -5111 -5006
Dpp4 -6557 -2216
Sec11c -3317 -4200
Tcf7l2 -2594 -4997
Pax6 -1636 -5784
Grp -1184 -3868
Pcsk1 -6740 -662
Sec11a -3335 -531

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ctnnb1 -2283 -4561 -2051 6367 1313
Dpp4 -3155 -6388 -6557 -6062 -2216
Gng13 3041 -3517 820 -5934 -1761
Grp 5515 -5745 -1184 1232 -3868
Pax6 -7834 -2105 -1636 -6307 -5784
Pcsk1 5418 -1585 -6740 7409 -662
Sec11a -201 3066 -3335 4438 -531
Sec11c -954 3943 -3317 -2746 -4200
Spcs1 2396 731 -5111 1558 -5006
Spcs2 -320 -1082 -7495 -57 -5753
Spcs3 -7674 -6721 -7356 4404 -7245
Tcf7l2 -5884 4873 -2594 -3039 -4997



PHASE 2 PLATEAU PHASE

PHASE 2 PLATEAU PHASE
metric value
setSize 10
pMANOVA 0.107
p.adjustMANOVA 0.198
s.dist 0.706
s.hyp 0.158
s.amy 0.161
s.hip 0.395
s.pag -0.185
s.ni 0.506
p.hyp 0.387
p.amy 0.378
p.hip 0.0305
p.pag 0.312
p.ni 0.00555 


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Top 20 genes
Gene ni hip
Cacng8 6977 7614
Cacng4 5699 6207
Cacna1c 6703 5252
Cacnb1 5416 6192
Cacng7 2124 6663
Cacna2d2 5109 2377
Kcne1l 1941 2868
Cacnb2 833 60

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Akap9 -855 265 -2867 -3751 7411
Cacna1c 1614 -536 5252 -3538 6703
Cacna2d2 -2370 804 2377 -4245 5109
Cacnb1 936 -2942 6192 2469 5416
Cacnb2 -4566 -3444 60 -4544 833
Cacng4 4162 2726 6207 -6610 5699
Cacng7 -3590 1762 6663 -78 2124
Cacng8 3342 -955 7614 -298 6977
Kcne1l 7813 6300 2868 7691 1941
Kcne4 4853 5005 130 -2751 -474



PROCESSING AND ACTIVATION OF SUMO

PROCESSING AND ACTIVATION OF SUMO
metric value
setSize 10
pMANOVA 0.0316
p.adjustMANOVA 0.0797
s.dist 0.704
s.hyp 0.0187
s.amy -0.296
s.hip -0.477
s.pag 0.229
s.ni -0.357
p.hyp 0.918
p.amy 0.105
p.hip 0.00905
p.pag 0.209
p.ni 0.0504 


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Top 20 genes
Gene hip ni
Sumo1 -7181 -7078
Sumo2 -7083 -7169
Rwdd3 -5973 -6027
Uba2 -2812 -4186
Ube2i -4965 -2117
Senp2 -3198 -2362
Sumo3 -1469 -4965
Sae1 -907 -33

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Rwdd3 -247 -5007 -5973 -4169 -6027
Sae1 5821 6648 -907 5230 -33
Senp1 3033 541 2643 -5813 5095
Senp2 -3667 -1409 -3198 -1174 -2362
Senp5 -4752 -5398 -3896 -3781 1885
Sumo1 -3770 -6023 -7181 4445 -7078
Sumo2 -6327 -5006 -7083 5371 -7169
Sumo3 4743 -2465 -1469 5954 -4965
Uba2 6454 -3425 -2812 6104 -4186
Ube2i -1030 -5842 -4965 5110 -2117



GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
metric value
setSize 11
pMANOVA 0.0117
p.adjustMANOVA 0.0368
s.dist 0.703
s.hyp 0.0315
s.amy -0.252
s.hip -0.0583
s.pag 0.545
s.ni -0.358
p.hyp 0.856
p.amy 0.148
p.hip 0.738
p.pag 0.00174
p.ni 0.0396 


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Top 20 genes
Gene pag ni
Rab2a 6043 -7739
Rab1a 5731 -6831
Mapk1 6645 -5590
Mapk3 7215 -4689
Uso1 6408 -4871
Blzf1 4636 -6716
Gorasp2 7064 -3794
Rab1b 5893 -2539

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Blzf1 -7584 -5265 -6423 4636 -6716
Golga2 5589 6946 7020 -2886 7807
Gorasp1 4632 -2697 7406 3814 5528
Gorasp2 778 -5955 3592 7064 -3794
Mapk1 -7830 -8169 -4424 6645 -5590
Mapk3 4329 -617 4642 7215 -4689
Plk1 5870 7552 -521 -3936 -305
Rab1a -4952 -5310 -7209 5731 -6831
Rab1b 6613 -3687 6533 5893 -2539
Rab2a -4633 -8165 -7240 6043 -7739
Uso1 -1406 -885 -5101 6408 -4871



RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
metric value
setSize 10
pMANOVA 0.0428
p.adjustMANOVA 0.101
s.dist 0.698
s.hyp 0.0103
s.amy -0.146
s.hip -0.239
s.pag 0.534
s.ni -0.353
p.hyp 0.955
p.amy 0.424
p.hip 0.19
p.pag 0.00348
p.ni 0.0535 


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Top 20 genes
Gene pag ni
Cul3 5424 -7480
Rab9b 5522 -5091
Ccne1 6961 -3334
Vhl 2083 -5569
Plin3 4896 -1441
Rhobtb3 372 -6305

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ccne1 -1786 2786 1742 6961 -3334
Cul3 -6896 -7036 -7565 5424 -7480
Hgs 6231 4543 6365 4968 4555
Htr7 7311 1680 1282 7396 2690
Lrrc41 1223 -4951 4228 4258 908
Plin3 6055 6558 -339 4896 -1441
Rab9 -4562 -457 -5572 -421 -5512
Rab9b 483 -3443 -7213 5522 -5091
Rhobtb3 -6383 -7597 -7002 372 -6305
Vhl -2085 -7531 -1885 2083 -5569



CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
metric value
setSize 10
pMANOVA 0.0755
p.adjustMANOVA 0.155
s.dist 0.69
s.hyp -0.0983
s.amy -0.242
s.hip -0.383
s.pag 0.412
s.ni -0.304
p.hyp 0.59
p.amy 0.186
p.hip 0.0361
p.pag 0.0242
p.ni 0.0958 


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Top 20 genes
Gene pag hip
Ywhaq 5561 -6520
Ywhab 4547 -7157
Ywhae 2625 -7208
Chek1 5634 -1876
Ywhah 3450 -2396
Ywhaz 1079 -7027
Wee1 3444 -938

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Chek1 -5378 -4929 -1876 5634 1043
Chek2 2785 1220 -4442 -1272 1241
Sfn 7023 5345 5582 5826 7621
Wee1 2168 5180 -938 3444 -3818
Ywhab -6185 -8153 -7157 4547 -7090
Ywhae -5259 -4163 -7208 2625 -6739
Ywhag 3712 -2390 4611 880 3935
Ywhah 2122 -1295 -2396 3450 -4770
Ywhaq -2420 -6465 -6520 5561 -7742
Ywhaz -7617 -7406 -7027 1079 -6415



MATURATION OF NUCLEOPROTEIN

MATURATION OF NUCLEOPROTEIN
metric value
setSize 10
pMANOVA 0.154
p.adjustMANOVA 0.261
s.dist 0.685
s.hyp -0.339
s.amy -0.165
s.hip -0.34
s.pag -0.34
s.ni -0.31
p.hyp 0.0637
p.amy 0.367
p.hip 0.0623
p.pag 0.0627
p.ni 0.0897 


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Top 20 genes
Gene hip pag
Parp14 -4436 -8023
Gsk3b -4855 -5112
Parp9 -4311 -5398
Parp10 -1769 -7094
Parp4 -1232 -7798

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Gsk3b -7096 -5614 -4855 -5112 848
Parp10 3911 149 -1769 -7094 -5419
Parp14 -8001 -8254 -4436 -8023 -5166
Parp16 -1339 -2299 595 -1445 -2454
Parp4 -3653 967 -1232 -7798 -784
Parp6 -4350 2268 1669 -887 1518
Parp8 13 4354 2483 -1798 3721
Parp9 -2850 3365 -4311 -5398 -6255
Sumo1 -3770 -6023 -7181 4445 -7078
Ube2i -1030 -5842 -4965 5110 -2117



REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
metric value
setSize 17
pMANOVA 0.00017
p.adjustMANOVA 0.00098
s.dist 0.684
s.hyp -0.13
s.amy 0.0211
s.hip 0.272
s.pag -0.247
s.ni 0.561
p.hyp 0.352
p.amy 0.88
p.hip 0.0525
p.pag 0.0773
p.ni 6.18e-05 


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Top 20 genes
Gene ni hip
Mov10 6527 6968
Pml 6029 6469
Ptpn11 6529 5776
Src 4784 7835
Ago2 7386 4164
Ago1 6051 4470
Ccnd3 1951 7370
Ago3 7780 1589
Tnrc6c 4533 2713
Cdk6 5834 2007
Ccnd2 2969 3724
Tnrc6a 7198 104

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ago1 -1679 -2432 4470 -122 6051
Ago2 -1087 -490 4164 -1325 7386
Ago3 -1084 3860 1589 -4547 7780
Ago4 -2589 -902 -2105 -898 5084
Cbfb -3385 -2213 -6678 5686 -2563
Ccnd1 -4600 -4370 -1322 -449 -4447
Ccnd2 -4794 -4374 3724 50 2969
Ccnd3 6403 4669 7370 6404 1951
Cdk6 -1470 -2176 2007 -6798 5834
Mov10 1769 6102 6968 -5956 6527
Pml -712 7399 6469 -5600 6029
Ptpn11 4220 4120 5776 3489 6529
Runx1 389 -1552 -957 -4493 4895
Src 3782 245 7835 2365 4784
Tnrc6a -4412 2203 104 -7484 7198
Tnrc6b -3079 -6095 -192 -7433 7768
Tnrc6c -7370 -7652 2713 -7982 4533



ACTIVATION OF SMO

ACTIVATION OF SMO
metric value
setSize 16
pMANOVA 0.0554
p.adjustMANOVA 0.124
s.dist 0.675
s.hyp 0.214
s.amy 0.3
s.hip 0.425
s.pag 0.0957
s.ni 0.361
p.hyp 0.138
p.amy 0.0379
p.hip 0.00321
p.pag 0.508
p.ni 0.0125 


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Top 20 genes
Gene hip ni
Evc 6938 8024
Arrb2 7967 6940
Iqce 6506 7559
Gas8 6580 7398
Evc2 7742 4349
Arrb1 4218 7789
Smo 7375 2737
Ptch1 1640 6498
Cdon 2592 989

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Arrb1 1261 4304 4218 1355 7789
Arrb2 6934 7482 7967 1552 6940
Boc -5331 -778 6354 -6240 -2021
Cdon -6078 -3706 2592 -7251 989
Csnk1a1 -4733 -8072 -6105 769 -6313
Efcab7 -7321 -8025 -4768 4585 746
Evc 7300 6572 6938 3801 8024
Evc2 7241 4919 7742 5341 4349
Gas1 6069 4235 6065 930 -95
Gas8 7373 7385 6580 4000 7398
Grk2 6871 43 7227 7572 -767
Iqce 6766 5803 6506 -2856 7559
Kif3a 175 4933 -1227 -7412 7528
Ptch1 -72 2807 1640 3119 6498
Shh -6238 485 -72 -3344 -3130
Smo 5037 3610 7375 4697 2737



IRE1ALPHA ACTIVATES CHAPERONES

IRE1ALPHA ACTIVATES CHAPERONES
metric value
setSize 49
pMANOVA 6.9e-07
p.adjustMANOVA 6.7e-06
s.dist 0.674
s.hyp 0.416
s.amy 0.218
s.hip 0.262
s.pag 0.354
s.ni 0.202
p.hyp 4.72e-07
p.amy 0.00843
p.hip 0.00154
p.pag 1.83e-05
p.ni 0.0144 


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Top 20 genes
Gene hyp pag
Pdia6 7686 7832
Hspa5 6928 7790
Xbp1 6736 7742
Dnajb11 7176 7076
Preb 7700 5757
Lmna 7431 5855
Tpp1 5203 7843
Dnajc3 4928 7824
Srprb 5326 7205
Dctn1 6550 5773
Cxxc1 7390 4817
Srpr 6056 5864
Yif1a 6247 5229
Hyou1 5562 5742
Syvn1 6597 4804
Ppp2r5b 4877 5361
Gosr2 5612 4633
Add1 5016 4480
Gsk3a 5073 4418
Klhdc3 6606 3332

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Acadvl 5813 736 1260 -4935 4840
Add1 5016 2067 5076 4480 6370
Arfgap1 5363 -1151 4847 -577 5194
Atp6v0d1 2504 -3670 2201 7111 -4555
Ctdsp2 -2514 5781 7763 -460 7043
Cul7 7372 3394 6456 -161 8036
Cxxc1 7390 6050 7570 4817 7382
Dctn1 6550 4612 6733 5773 5589
Ddx11 3996 1572 4399 -7 4368
Dnajb11 7176 4399 -4669 7076 -2459
Dnajb9 -6522 -4785 -7637 6602 -7701
Dnajc3 4928 2471 -4262 7824 -324
Edem1 -4957 -2584 -3656 -965 1325
Ern1 -1411 -7425 2145 -978 6069
Extl1 -4461 -4168 5839 -3476 3472
Extl2 -7398 -4911 -6838 1660 -6221
Extl3 2340 800 6163 120 7280
Fkbp14 3905 -5568 -3838 3474 -3556
Gfpt1 -3423 -1717 -5285 6606 1503
Gosr2 5612 -496 1740 4633 554
Gsk3a 5073 3131 6345 4418 2834
Hdgf 7015 7443 -2857 2419 957
Hspa5 6928 4928 -3462 7790 -3568
Hyou1 5562 4676 4019 5742 5696
Klhdc3 6606 2155 3825 3332 1159
Lmna 7431 910 4716 5855 1727
Mydgf 6643 -1434 4870 -390 -4001
Pdia5 3683 3345 5350 -6043 1769
Pdia6 7686 5773 2773 7832 1523
Pla2g4b 5242 -6009 6368 326 4246
Ppp2r5b 4877 7364 8015 5361 -2732
Preb 7700 6747 7658 5757 5124
Sec31a -1217 4188 4386 2473 4609
Serp1 -4081 -7877 -6615 4034 -6609
Shc1 2685 6899 5481 1214 5529
Srpr 6056 4554 3021 5864 844
Srprb 5326 3597 4283 7205 1575
Ssr1 -4207 -5370 -7445 4894 -6678
Sult1a1 4264 6672 -1721 -405 2750
Syvn1 6597 1585 8092 4804 4844
Tatdn2 748 -4615 3301 -2424 1171
Tln1 7242 7190 7918 522 8025
Tpp1 5203 5273 7563 7843 2346
Tspyl2 5597 5656 3277 -18 4168
Wfs1 -4561 -723 4957 -2618 4603
Wipi1 -1930 -6056 -1865 -5897 2594
Xbp1 6736 3437 -2496 7742 -4023
Yif1a 6247 104 3052 5229 -4429
Zbtb17 3247 6875 7888 1319 5476



INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS
metric value
setSize 27
pMANOVA 8.47e-08
p.adjustMANOVA 9.79e-07
s.dist 0.674
s.hyp -0.253
s.amy 0.0476
s.hip 0.223
s.pag -0.273
s.ni 0.513
p.hyp 0.0228
p.amy 0.669
p.hip 0.0448
p.pag 0.014
p.ni 3.9e-06 


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Top 20 genes
Gene ni pag
Scn8a 7316 -7566
Ank3 6819 -7687
Ank2 7509 -5454
Ank1 5910 -4802
Scn9a 4757 -5338
Scn2b 5440 -4582
Sptbn4 8065 -3085
Scn3a 2992 -5457
Scn2a 2188 -7005
Sptb 6125 -2425
Sptbn2 5980 -2127
Kcnq3 1857 -5603
Kcnq2 7585 -1179
Scn4b 3042 -2755
Nfasc 7998 -916
Sptbn1 5860 -775
Scn1a 1399 -3242
Scn5a 5674 -713

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Actb -6899 -2667 4643 -7405 -2370
Actg1 -2568 -3507 725 1838 -5668
Ank1 2218 3687 2543 -4802 5910
Ank2 -2866 1127 3174 -5454 7509
Ank3 -6785 782 -650 -7687 6819
Kcnq2 -1876 -957 6660 -1179 7585
Kcnq3 -7331 -4876 -3627 -5603 1857
L1cam 3306 3386 4992 3086 5772
Nfasc 146 5847 7288 -916 7998
Nrcam -4622 -7809 -1236 645 3056
Scn1a -7332 -2676 -4601 -3242 1399
Scn1b 1525 1301 6413 -1787 -2292
Scn2a -5257 -7319 -4977 -7005 2188
Scn2b -1574 1393 1772 -4582 5440
Scn3a -5310 -2972 -671 -5457 2992
Scn3b -6375 3554 5587 6924 1963
Scn4b -7304 -1546 844 -2755 3042
Scn5a 2520 3648 4822 -713 5674
Scn7a 1350 -6595 -5156 4644 3502
Scn8a -7467 -30 5461 -7566 7316
Scn9a 1791 -1656 -3382 -5338 4757
Sptan1 -839 555 4804 580 5998
Sptb -566 2031 6350 -2425 6125
Sptbn1 -1022 1953 1989 -775 5860
Sptbn2 -1926 1955 7364 -2127 5980
Sptbn4 4476 7367 8168 -3085 8065
Sptbn5 2973 3890 -3140 978 7552



REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
metric value
setSize 11
pMANOVA 0.00491
p.adjustMANOVA 0.0177
s.dist 0.672
s.hyp 0.0202
s.amy 0.215
s.hip 0.421
s.pag 0.385
s.ni 0.283
p.hyp 0.908
p.amy 0.216
p.hip 0.0157
p.pag 0.0271
p.ni 0.104 


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Top 20 genes
Gene hip pag
Banp 7822 7407
Ppp1r13b 7531 7230
Trp73 7022 7285
Ppp1r13l 6342 3781
Akt1 6561 2674
Trp53 5025 3491
Zfp385a 6090 2334

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Akt1 6360 2343 6561 2674 397
Akt2 241 1465 2119 -797 2648
Akt3 -6387 -7032 -1727 -507 867
Banp 7743 7465 7822 7407 7690
Phf20 -1897 -1594 -3976 1029 -196
Ppp1r13b 4184 5941 7531 7230 7304
Ppp1r13l 5378 -3685 6342 3781 4507
Trp53 1104 -447 5025 3491 2673
Trp53bp2 -4402 2725 -2633 -1333 -678
Trp73 -5229 1174 7022 7285 296
Zfp385a -6681 6262 6090 2334 895



DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
metric value
setSize 20
pMANOVA 0.00577
p.adjustMANOVA 0.0201
s.dist 0.669
s.hyp 0.309
s.amy 0.179
s.hip 0.288
s.pag 0.235
s.ni 0.426
p.hyp 0.0166
p.amy 0.166
p.hip 0.0258
p.pag 0.0694
p.ni 0.000975 


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Top 20 genes
Gene ni hyp
Sdc4 7051 7439
Gpc4 6059 6446
Bcan 6478 5492
Gpc2 7148 3927
Sdc3 3899 4151
Bgn 3567 4177
Gpc3 4712 2894
Agrn 6886 1857
B4galt7 2657 3195
Gpc1 3844 1878
Gpc6 1123 5520

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Agrn 1857 5079 6976 -2087 6886
B4galt7 3195 0 2959 5552 2657
Bcan 5492 7047 7475 4457 6478
Bgn 4177 7435 5048 6132 3567
Cspg4 -1585 1525 6056 4601 7498
Cspg5 6016 -2551 1800 4301 -530
Dcn -131 -4506 -5216 -2118 214
Gpc1 1878 -106 6925 137 3844
Gpc2 3927 4796 3880 -5869 7148
Gpc3 2894 1569 -2076 6894 4712
Gpc4 6446 -5409 6684 1732 6059
Gpc5 -14 1981 -4173 4060 -289
Gpc6 5520 -2317 2296 -3503 1123
Hspg2 -1276 2547 7036 -7744 3879
Ncan -2362 3715 5415 -3033 7228
Sdc1 5421 -4337 -1295 2651 -55
Sdc2 -2982 -3291 -7089 2662 -4306
Sdc3 4151 -1359 5364 3172 3899
Sdc4 7439 6841 3214 7101 7051
Vcan -3346 2113 639 6252 3561



COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN
metric value
setSize 10
pMANOVA 0.00997
p.adjustMANOVA 0.0323
s.dist 0.667
s.hyp -0.342
s.amy 0.102
s.hip -0.524
s.pag -0.182
s.ni -0.0972
p.hyp 0.061
p.amy 0.577
p.hip 0.00413
p.pag 0.319
p.ni 0.595 


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Top 20 genes
Gene hip hyp
Rad21 -7191 -6082
Stag2 -7036 -5617
Smc3 -7435 -4861
Stag1 -3766 -6562
Pds5b -5815 -3453
Wapl -5359 -3622
Pds5a -2947 -2714
Nipbl -4397 -1661

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Mau2 5121 6687 8229 -3379 7631
Nipbl -1661 3959 -4397 -5262 5957
Pds5a -2714 3273 -2947 11 -1254
Pds5b -3453 -1871 -5815 5159 -5637
Rad21 -6082 -2810 -7191 5422 -6261
Smc1a 1014 4020 -2866 1093 2375
Smc3 -4861 3641 -7435 -7471 63
Stag1 -6562 -428 -3766 -3811 -929
Stag2 -5617 -5076 -7036 -885 -4755
Wapl -3622 -7119 -5359 -6327 -3459



NF KB IS ACTIVATED AND SIGNALS SURVIVAL

NF KB IS ACTIVATED AND SIGNALS SURVIVAL
metric value
setSize 12
pMANOVA 0.135
p.adjustMANOVA 0.236
s.dist 0.666
s.hyp 0.327
s.amy 0.44
s.hip 0.276
s.pag -0.0868
s.ni 0.243
p.hyp 0.0497
p.amy 0.00829
p.hip 0.0975
p.pag 0.603
p.ni 0.144 


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Top 20 genes
Gene amy hyp
Ikbkb 6232 4514
Irak1 5996 4580
Nfkb1 6216 3358
Ubb 2476 6745
Uba52 3662 4277
Rps27a 5541 2364
Ubc 2920 2434
Sqstm1 696 6949
Nfkbia 2003 909
Rela 28 5057

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ikbkb 4514 6232 7261 -2788 7901
Irak1 4580 5996 5773 -5368 4576
Nfkb1 3358 6216 3738 -520 4853
Nfkbia 909 2003 -95 -982 -849
Ngfr -6204 5247 -1150 -1901 4281
Rela 5057 28 7243 -2441 6255
Rps27a 2364 5541 -3759 -441 -3739
Sqstm1 6949 696 1624 6307 -1439
Traf6 -5240 -3613 -1651 583 667
Uba52 4277 3662 1163 -7268 3243
Ubb 6745 2476 5259 1194 -3830
Ubc 2434 2920 4638 4179 3062



BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM
metric value
setSize 23
pMANOVA 1.87e-05
p.adjustMANOVA 0.000136
s.dist 0.661
s.hyp 0.169
s.amy 0.116
s.hip -0.208
s.pag 0.517
s.ni -0.289
p.hyp 0.161
p.amy 0.335
p.hip 0.0838
p.pag 1.75e-05
p.ni 0.0165 


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Top 20 genes
Gene pag ni
Arl6 6530 -7448
Lztfl1 6077 -7433
Tcp1 6208 -6815
Cct4 5832 -6863
Bbs10 7385 -5279
Cct5 6862 -5371
Cct8 6059 -5002
Rab3ip 5805 -5081
Mkks 7525 -3849
Cct2 3551 -6409
Cct3 6697 -2598
Bbip1 1697 -6628
Mchr1 6796 -940
Bbs4 1526 -2579

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Arl6 -4543 -3633 -6470 6530 -7448
Bbip1 -2830 -3897 -5754 1697 -6628
Bbs1 1962 4812 5781 5524 7038
Bbs10 -4629 2330 -4282 7385 -5279
Bbs12 161 4430 -2827 -5212 -4492
Bbs2 2938 3701 4320 1996 6077
Bbs4 -2801 2092 -2048 1526 -2579
Bbs5 -3817 -7146 -6004 -5136 -5879
Bbs7 4222 7100 -672 4195 4003
Bbs9 6455 939 -288 6777 7022
Cct2 580 -1968 -5946 3551 -6409
Cct3 6694 2897 -654 6697 -2598
Cct4 3515 41 -6868 5832 -6863
Cct5 7361 1553 1983 6862 -5371
Cct8 -2034 -5 -7370 6059 -5002
Lztfl1 -5088 -7630 -7152 6077 -7433
Mchr1 496 -3308 207 6796 -940
Mkks 3610 7058 -66 7525 -3849
Rab3ip 5761 593 4125 5805 -5081
Smo 5037 3610 7375 4697 2737
Sstr3 4415 -3275 6111 -4845 4312
Tcp1 -2953 -5257 -7114 6208 -6815
Ttc8 3493 7387 2603 5758 2057



NITRIC OXIDE STIMULATES GUANYLATE CYCLASE

NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
metric value
setSize 20
pMANOVA 0.000515
p.adjustMANOVA 0.00261
s.dist 0.658
s.hyp -0.513
s.amy -0.271
s.hip -0.196
s.pag -0.225
s.ni 0.0842
p.hyp 7.11e-05
p.amy 0.0356
p.hip 0.129
p.pag 0.0819
p.ni 0.514 


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Top 20 genes
Gene hyp amy
Pde1a -7442 -8246
Gucy1a1 -8026 -6390
Kcnma1 -6803 -7233
Gucy1b1 -6437 -5313
Prkg1 -4720 -6307
Pde2a -6948 -3509
Itpr1 -6907 -3526
Gucy1a2 -5173 -3780
Pde10a -7598 -2101
Pde11a -3616 -4003
Pde5a -6276 -1788
Kcnmb4 -3552 -2725

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Gucy1a1 -8026 -6390 -6700 -5687 -4548
Gucy1a2 -5173 -3780 291 -7690 6938
Gucy1b1 -6437 -5313 -6155 6562 -2791
Irag1 -1148 1923 1959 -2080 4564
Itpr1 -6907 -3526 -769 -5929 800
Kcnma1 -6803 -7233 -5593 -4825 4856
Kcnmb1 4221 -5483 -5385 1783 3211
Kcnmb2 -8067 1484 -4902 -2596 -5837
Kcnmb4 -3552 -2725 1374 -2455 -7329
Nos1 2584 -1178 2287 -4744 4496
Nos3 1596 7551 7661 4076 7875
Pde10a -7598 -2101 2750 -4236 4193
Pde11a -3616 -4003 -1820 -6514 4842
Pde1a -7442 -8246 -5233 1502 -2829
Pde1b -7659 303 5422 1395 3840
Pde2a -6948 -3509 5282 525 -759
Pde5a -6276 -1788 -4560 -5347 -3381
Pde9a 2403 -2777 -710 -467 -2498
Prkg1 -4720 -6307 -4239 -2647 -2492
Prkg2 -4448 2290 -6025 1704 3155



AGGREPHAGY

AGGREPHAGY
metric value
setSize 34
pMANOVA 3.97e-05
p.adjustMANOVA 0.000265
s.dist 0.656
s.hyp 0.415
s.amy 0.33
s.hip 0.222
s.pag 0.314
s.ni 0.0265
p.hyp 2.76e-05
p.amy 0.000861
p.hip 0.0251
p.pag 0.00152
p.ni 0.789 


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Top 20 genes
Gene hyp amy
Hsf1 7668 7451
Tubb4a 6675 7115
Vim 7001 6753
Tubb3 6704 6742
Tubb6 6888 5268
Hdac6 5011 6432
Vcp 5626 4454
Dynll2 3754 6485
Tuba1b 7288 3199
Park7 4309 4303
Ubb 6745 2476
Uba52 4277 3662
Tuba4a 4780 2822
Rps27a 2364 5541
Tubb4b 7429 1199
Dync1h1 2185 3971
Ubc 2434 2920
Tubb2a 7422 936
Tubb2b 5998 573
Dync1i1 5931 545

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Arl13b -3313 1630 -5087 2286 -1890
Dync1h1 2185 3971 6220 1230 7913
Dync1i1 5931 545 1969 5363 -1604
Dync1i2 -3739 -2332 -5529 -3545 -5951
Dync1li1 2083 1165 -1861 2435 -320
Dync1li2 -4067 -2852 -4877 -3221 3271
Dynll1 1911 -2055 -36 3347 -3624
Dynll2 3754 6485 2099 -1716 6877
Hdac6 5011 6432 7776 -3717 7953
Hsf1 7668 7451 8166 6743 7565
Hsp90aa1 -7084 -5026 -7549 -2711 -6655
Ift88 5176 259 -4274 7701 3869
Park7 4309 4303 -888 -1310 -2265
Pcnt -3306 2493 6055 -6986 4116
Prkn -1335 7156 1854 -3408 4931
Rps27a 2364 5541 -3759 -441 -3739
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873
Uba52 4277 3662 1163 -7268 3243
Ubb 6745 2476 5259 1194 -3830
Ubc 2434 2920 4638 4179 3062
Ube2n -6652 -5866 -7434 6360 -7239
Ube2v1 3386 -73 154 5458 -2691
Vcp 5626 4454 -2391 6939 1495
Vim 7001 6753 5456 6827 6909



ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
metric value
setSize 19
pMANOVA 0.0108
p.adjustMANOVA 0.0347
s.dist 0.651
s.hyp -0.0758
s.amy -0.228
s.hip -0.314
s.pag 0.311
s.ni -0.414
p.hyp 0.567
p.amy 0.0856
p.hip 0.0179
p.pag 0.0188
p.ni 0.00179 


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Top 20 genes
Gene ni hip
P2ry12 -7423 -6696
Gnai3 -6257 -6401
Gng2 -5776 -6824
Gng10 -7068 -5148
Gnai1 -5916 -6129
Gng11 -6408 -5244
Gnb4 -5321 -5408
Gng12 -2901 -6140
Gng5 -2491 -3712
Gnb1 -642 -4731
Gng3 -2061 -913

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Gnai1 -2588 -8320 -6129 4518 -5916
Gnai2 5779 -1103 4440 5326 -2017
Gnai3 -4780 -4805 -6401 5502 -6257
Gnb1 -3397 -6373 -4731 5929 -642
Gnb2 5207 -168 6369 3158 -3237
Gnb4 -6588 -7713 -5408 -2506 -5321
Gnb5 -2381 2239 1479 4185 -4199
Gng10 -630 -5350 -5148 304 -7068
Gng11 -2462 -345 -5244 -6384 -6408
Gng12 -4462 -6054 -6140 7562 -2901
Gng13 3041 -3517 820 -5934 -1761
Gng2 -4697 -7636 -6824 7413 -5776
Gng3 3147 4488 -913 1336 -2061
Gng4 6665 663 -2322 5117 4762
Gng5 2872 -783 -3712 3372 -2491
Gng7 -6292 -389 4194 4359 -1199
Gng8 3846 5580 794 4314 1052
Gngt2 1363 4341 28 -6379 -875
P2ry12 -7430 -6437 -6696 3971 -7423



RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
metric value
setSize 12
pMANOVA 0.0112
p.adjustMANOVA 0.0357
s.dist 0.65
s.hyp 0.232
s.amy -0.0734
s.hip 0.263
s.pag 0.541
s.ni 0.0344
p.hyp 0.164
p.amy 0.66
p.hip 0.115
p.pag 0.00117
p.ni 0.837 


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Top 20 genes
Gene pag hip
Dnm2 7134 8077
Ap2a1 5697 7718
Ap2m1 7301 3919
Dnal4 6913 3600
Ap2a2 6537 2347
Ap2b1 7047 1651
Clta 3298 2028
Dnm1 747 5789

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ap2a1 6184 5019 7718 5697 5639
Ap2a2 3984 -3416 2347 6537 4381
Ap2b1 -2043 -2963 1651 7047 2714
Ap2m1 5631 1349 3919 7301 -2631
Ap2s1 5917 216 4433 -3155 -3439
Clta 6398 -608 2028 3298 -5356
Cltc -4737 -7131 -5792 4163 -2799
Dnal4 6272 -1105 3600 6913 -287
Dnm1 -111 768 5789 747 2710
Dnm2 5710 7331 8077 7134 7894
Dnm3 -7311 -3788 -3404 2126 -2107
Sh3gl2 -5222 -7269 -1629 2654 -1687



INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION
metric value
setSize 13
pMANOVA 0.0169
p.adjustMANOVA 0.0499
s.dist 0.649
s.hyp -0.0646
s.amy -0.139
s.hip -0.513
s.pag 0.0676
s.ni -0.361
p.hyp 0.687
p.amy 0.385
p.hip 0.00135
p.pag 0.673
p.ni 0.0243 


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Top 20 genes
Gene hip ni
Spcs3 -7356 -7245
Spcs2 -7495 -5753
Spcs1 -5111 -5006
Dpp4 -6557 -2216
Sec11c -3317 -4200
Tcf7l2 -2594 -4997
Pax6 -1636 -5784
Grp -1184 -3868
Pcsk1 -6740 -662
Sec11a -3335 -531

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ctnnb1 -2283 -4561 -2051 6367 1313
Dpp4 -3155 -6388 -6557 -6062 -2216
Gng13 3041 -3517 820 -5934 -1761
Grp 5515 -5745 -1184 1232 -3868
Isl1 3661 -269 -2511 4463 5316
Pax6 -7834 -2105 -1636 -6307 -5784
Pcsk1 5418 -1585 -6740 7409 -662
Sec11a -201 3066 -3335 4438 -531
Sec11c -954 3943 -3317 -2746 -4200
Spcs1 2396 731 -5111 1558 -5006
Spcs2 -320 -1082 -7495 -57 -5753
Spcs3 -7674 -6721 -7356 4404 -7245
Tcf7l2 -5884 4873 -2594 -3039 -4997



INTERFERON ALPHA BETA SIGNALING

INTERFERON ALPHA BETA SIGNALING
metric value
setSize 51
pMANOVA 1.09e-08
p.adjustMANOVA 1.47e-07
s.dist 0.646
s.hyp -0.214
s.amy -0.305
s.hip -0.198
s.pag -0.39
s.ni -0.296
p.hyp 0.00817
p.amy 0.000169
p.hip 0.0145
p.pag 1.5e-06
p.ni 0.000258 


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Top 20 genes
Gene pag amy
Irf7 -8052 -8340
H2-T23 -8029 -8307
Isg15 -8025 -8303
Usp18 -8040 -8277
Bst2 -7972 -8296
Rsad2 -8028 -8161
Ifit3 -7895 -8051
H2-Q4 -8018 -7772
Oas1a -8046 -7608
Xaf1 -7824 -7439
Psmb8 -7984 -6998
Stat1 -7192 -7602
Ifnar1 -6188 -7552
Samhd1 -7845 -5625
Irf1 -7638 -5757
H2-D1 -4553 -8096
H2-K1 -7083 -5093
Ifitm3 -7301 -4026
H2-Q7 -6899 -4029
Ifi27 -7857 -3533

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Abce1 -7053 -5760 -7084 7071 -6682
Adar 604 301 4033 993 3978
Bst2 -6282 -8296 -1984 -7972 -6727
Egr1 -1917 -1120 -1676 -4774 -6806
Gbp2 -4466 -8002 -4551 4765 -5778
H2-D1 -4844 -8096 -4485 -4553 -5338
H2-K1 -6725 -5093 -5409 -7083 -5377
H2-M3 -2204 6096 262 -7743 -6339
H2-Q10 2677 -1183 -3328 -6247 639
H2-Q4 -6060 -7772 -5534 -8018 -4910
H2-Q7 -5007 -4029 -2166 -6899 -4153
H2-T22 5071 7085 1153 -4733 -2894
H2-T23 -7159 -8307 -6295 -8029 -7418
Ifi27 743 -3533 -2888 -7857 -4137
Ifi35 2147 -2437 872 -7913 -4603
Ifit1bl1 -4619 -5811 -1987 2276 -1390
Ifit2 -7317 -7500 -7033 541 -2821
Ifit3 -3612 -8051 -6507 -7895 -4987
Ifitm1 6201 7556 6961 4307 7028
Ifitm2 -1441 -3124 5128 16 -378
Ifitm3 -3295 -4026 -2419 -7301 -6207
Ifnar1 -5425 -7552 -2678 -6188 5070
Ifnar2 876 -4861 -4618 -2726 -5868
Ip6k2 7566 1206 7337 7441 1348
Irf1 -4581 -5757 863 -7638 -7262
Irf2 -1948 5210 -804 957 -4551
Irf3 5906 6828 6529 1118 6407
Irf5 -615 3839 5606 -2161 -2238
Irf7 -8080 -8340 -7558 -8052 -7751
Irf8 4467 -478 1688 -2132 955
Irf9 -2174 2256 -784 -4993 -3300
Isg15 -7499 -8303 -6368 -8025 -7283
Jak1 -3411 -8209 -2852 2064 -637
Kpna1 -5870 -6801 -7085 4785 -6346
Kpnb1 -1781 -1081 -1658 2866 2604
Mx2 -948 -1172 -611 -7758 -46
Oas1a -6420 -7608 -5471 -8046 -5762
Psmb8 -6397 -6998 -3085 -7984 -5667
Ptpn1 3910 3981 7205 -2085 32
Ptpn11 4220 4120 5776 3489 6529
Ptpn6 1704 7241 2410 242 640
Rnasel -7552 365 -3701 -6827 4785
Rsad2 -6769 -8161 -6262 -8028 -7209
Samhd1 -4739 -5625 -3324 -7845 -2298
Socs1 7617 -7845 -2247 4895 6531
Socs3 6204 -6939 2845 1705 1811
Stat1 -3711 -7602 -4215 -7192 -5039
Stat2 4325 6066 6285 -3338 4616
Tyk2 5759 6302 7498 1847 6731
Usp18 -6108 -8277 -6201 -8040 -6745
Xaf1 -6886 -7439 -3972 -7824 -7004



WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
metric value
setSize 13
pMANOVA 0.0246
p.adjustMANOVA 0.0667
s.dist 0.638
s.hyp 0.473
s.amy 0.0656
s.hip 0.144
s.pag 0.396
s.ni 0.0287
p.hyp 0.00314
p.amy 0.682
p.hip 0.367
p.pag 0.0134
p.ni 0.858 


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Top 20 genes
Gene hyp pag
Fzd2 7263 7692
Ap2m1 5631 7301
Fzd5 5769 6251
Ap2a1 6184 5697
Ap2a2 3984 6537
Clta 6398 3298
Cltb 7066 2893
Ror2 854 2935

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ap2a1 6184 5019 7718 5697 5639
Ap2a2 3984 -3416 2347 6537 4381
Ap2b1 -2043 -2963 1651 7047 2714
Ap2m1 5631 1349 3919 7301 -2631
Ap2s1 5917 216 4433 -3155 -3439
Clta 6398 -608 2028 3298 -5356
Cltb 7066 7429 2400 2893 819
Cltc -4737 -7131 -5792 4163 -2799
Fzd2 7263 7223 6396 7692 7173
Fzd5 5769 -6662 551 6251 6189
Ror1 2652 -3871 -1221 -5886 -6463
Ror2 854 5898 -2273 2935 78
Wnt5a 2373 -685 -3234 -5085 -1443



SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
metric value
setSize 20
pMANOVA 0.000776
p.adjustMANOVA 0.00368
s.dist 0.637
s.hyp -0.224
s.amy -0.0124
s.hip -0.342
s.pag 0.379
s.ni -0.307
p.hyp 0.0836
p.amy 0.923
p.hip 0.00802
p.pag 0.00333
p.ni 0.0176 


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Top 20 genes
Gene pag hip
Acsl4 7261 -7561
Hsd17b12 7148 -6708
Elovl4 5450 -6912
Hacd3 5481 -6629
Acsl3 3976 -7537
Acsl5 4573 -5035
Hacd2 6088 -3452
Acsl6 5639 -2420
Elovl5 2444 -5579
Elovl2 2425 -4915
Acsl1 2522 -2646
Elovl6 2659 -849

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Acsbg1 3439 7001 6690 7153 3303
Acsf3 3933 -2581 450 -1653 3377
Acsl1 -6972 -4000 -2646 2522 541
Acsl3 -4970 -3741 -7537 3976 -5600
Acsl4 -5042 -6453 -7561 7261 -4075
Acsl5 -3050 -4783 -5035 4573 -2173
Acsl6 -5733 420 -2420 5639 -1708
Elovl1 3245 7567 7017 7001 -2387
Elovl2 -6515 -855 -4915 2425 -5885
Elovl4 -6045 -6755 -6912 5450 -7517
Elovl5 -5711 390 -5579 2444 -4346
Elovl6 -4170 3482 -849 2659 5325
Elovl7 -7170 -7633 -6496 -7170 -7806
Hacd1 1850 2146 -4670 -7674 -5808
Hacd2 820 -3671 -3452 6088 -2916
Hacd3 -627 3600 -6629 5481 -7516
Hacd4 -1482 -3020 -3003 -3520 -463
Hsd17b12 -5439 -286 -6708 7148 -7322
Slc27a3 7113 2586 8046 1961 2257
Tecr 4536 6953 3912 6570 4876



THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION

THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION
metric value
setSize 13
pMANOVA 0.000445
p.adjustMANOVA 0.00234
s.dist 0.636
s.hyp 0.094
s.amy -0.376
s.hip 0.0607
s.pag 0.0888
s.ni -0.492
p.hyp 0.557
p.amy 0.0189
p.hip 0.705
p.pag 0.579
p.ni 0.00211 


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Top 20 genes
Gene ni amy
Abca4 -7581 -7669
Ttr -6839 -6563
Rdh5 -5715 -6787
Cyp4v3 -5999 -4231
Stra6 -7641 -3269
Napepld -4762 -3473
Rdh10 -2379 -6289

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Abca4 -4457 -7669 1555 -1108 -7581
Cyp4v3 -4820 -4231 -5949 5401 -5999
Myo7a 6836 -2643 5051 5810 2870
Napepld -1597 -3473 -221 4565 -4762
Rbp1 3771 2563 2197 -732 -3271
Rbp4 3753 -4672 -3045 4700 1965
Rdh10 1428 -6289 -3016 -1194 -2379
Rdh11 1972 884 -3783 4213 -6385
Rdh12 -3098 2639 2389 -7033 -4583
Rdh5 6508 -6787 6693 6005 -5715
Rlbp1 -2825 -4339 -246 1066 1320
Stra6 -5400 -3269 4059 -7582 -7641
Ttr 6044 -6563 4576 -6192 -6839



EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
metric value
setSize 87
pMANOVA 1.68e-38
p.adjustMANOVA 6.46e-36
s.dist 0.635
s.hyp 0.303
s.amy 0.436
s.hip -0.131
s.pag -0.191
s.ni -0.261
p.hyp 1.08e-06
p.amy 2.05e-12
p.hip 0.0348
p.pag 0.00207
p.ni 2.57e-05 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene amy hyp
Eef1d 6454 6989
Rps28 7193 5451
Rpl26 6969 5134
Rpl38 6271 5561
Rps29 6247 5470
Rps8 7055 4661
Eef2 5827 5415
Rpl8 4908 6167
Rplp2 6257 4669
Rps21 5409 5344
Eef1a2 5939 3820
Rpl37a 5251 4253
Rpl13 3761 5775
Rpl23a 5824 3660
Rps6 3541 6000
Rplp1 4256 4918
Rps9 5296 3860
Rpl7a 4249 4437
Rps19 5112 3476
Fau 3512 5019

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Eef1a1 4082 -2694 -390 5649 -6416
Eef1a2 3820 5939 4633 5909 -622
Eef1b2 5666 2658 -2615 1268 -4211
Eef1d 6989 6454 4607 -1688 1315
Eef1g 915 4416 -4986 -163 -4541
Eef2 5415 5827 5601 5740 4911
Fau 5019 3512 2433 -5246 -1411
Rpl10 4266 3549 2250 7744 6036
Rpl10a 2470 851 931 -5590 4759
Rpl11 1853 2196 -2264 -2042 -4030
Rpl12 3416 3581 3691 -4947 2909
Rpl13 5775 3761 3144 994 159
Rpl13a -755 392 -2304 -3551 -1654
Rpl14 -683 3803 -3482 -2833 -3831
Rpl15 1253 -3149 -4230 -2059 -4605
Rpl17 -2730 -2556 -2820 -536 -4989
Rpl18 4193 1768 2785 -2025 -3069
Rpl18a 3793 3709 285 1339 -2718
Rpl19 5189 2527 950 -1643 -3438
Rpl21 4849 2861 1074 4520 -4118
Rpl22 -1893 700 -3708 -1568 -4791
Rpl22l1 -3671 -3188 -7061 1820 -6124
Rpl23 2144 5333 -2293 -3875 -1639
Rpl23a 3660 5824 -383 2426 -3712
Rpl24 -1292 4245 -4427 -2877 -4842
Rpl26 5134 6969 -3625 423 2203
Rpl27 3334 512 -250 -2271 -113
Rpl27a 2125 2736 -4406 -616 -3337
Rpl28 670 6741 1611 -5100 1924
Rpl29 -1362 -296 -3909 -3804 -1849
Rpl3 166 2513 -4850 -7309 -519
Rpl30 -6144 3241 -6200 -2009 -67
Rpl31 3402 3091 99 -5864 1588
Rpl32 1815 3797 510 -4765 -2582
Rpl34 1726 -353 2106 -1573 -3911
Rpl35 2921 5926 1123 -5441 -1451
Rpl35a -2654 4492 -6607 -2640 -3302
Rpl36 5535 2315 4294 -4708 -2219
Rpl36a 3363 882 -3047 -4738 -1239
Rpl36al 4273 2607 1155 -2851 -2777
Rpl37 3059 5237 3584 -4180 1089
Rpl37a 4253 5251 2588 -5824 -1258
Rpl38 5561 6271 3978 -7455 1641
Rpl39 5473 -2304 482 -1629 -3040
Rpl4 2953 830 -2884 2097 -4767
Rpl5 -4980 1227 -6319 -5493 -273
Rpl6 2890 5093 -3990 -1116 -4413
Rpl7 -457 -1282 -3511 568 -5886
Rpl7a 4437 4249 1467 3265 -3741
Rpl8 6167 4908 2661 -811 -1928
Rpl9 463 1415 -2873 342 -4659
Rplp0 2811 -293 -2676 255 -3496
Rplp1 4918 4256 2253 -1200 -1019
Rplp2 4669 6257 3646 -3984 -2011
Rps10 4052 2818 1426 -176 -2577
Rps11 -837 3714 499 -237 -1060
Rps12 3364 1152 3657 -3077 25
Rps13 935 5647 -2776 -2854 -1932
Rps14 2791 2977 -1040 -2656 -1610
Rps15 5041 2864 2770 -3957 -965
Rps15a 5104 -1842 -230 2531 -3199
Rps16 -1427 3232 -1487 -6753 -2322
Rps17 1882 3720 334 552 -2765
Rps18 -5478 4981 -7621 4036 -5349
Rps19 3476 5112 -268 -3453 -2839
Rps2 -5203 5392 -5984 -5110 3506
Rps20 5148 -229 740 -3005 -1637
Rps21 5344 5409 1551 -4019 -1362
Rps23 -59 829 -2278 -5285 -734
Rps24 126 2908 -3750 139 -4122
Rps25 -898 4112 -1654 -3130 -3248
Rps26 522 5238 678 -2098 -2089
Rps27 2965 1580 240 -2563 -2309
Rps27a 2364 5541 -3759 -441 -3739
Rps27l -3424 4523 -3284 -989 -4324
Rps28 5451 7193 4516 -6395 1508
Rps29 5470 6247 5205 -7076 3680
Rps3 2498 -733 -3034 1462 -3502
Rps3a1 3163 3977 -4292 2362 -5585
Rps4x -1373 5240 -4055 842 -4816
Rps5 6087 2128 2241 393 -2706
Rps6 6000 3541 -1989 1788 -3475
Rps7 -3597 2589 -6916 3505 -4546
Rps8 4661 7055 -2149 -2815 -41
Rps9 3860 5296 -961 -2795 -2377
Rpsa 5082 2475 1168 162 -1750
Uba52 4277 3662 1163 -7268 3243



GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
metric value
setSize 12
pMANOVA 0.0537
p.adjustMANOVA 0.121
s.dist 0.634
s.hyp 0.412
s.amy 0.179
s.hip 0.102
s.pag 0.436
s.ni -0.00353
p.hyp 0.0134
p.amy 0.283
p.hip 0.542
p.pag 0.0089
p.ni 0.983 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene pag hyp
Gaa 7059 7250
G6pc3 6017 6317
Nhlrc1 6493 5035
Gbe1 6844 3757
Ubc 4179 2434
Ppp1r3c 2676 3591
Ubb 1194 6745
Gys1 1736 3871

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Epm2a -6244 -8250 -5742 4737 -1321
G6pc3 6317 -98 5417 6017 3152
Gaa 7250 438 6768 7059 5284
Gbe1 3757 -3283 -3788 6844 -6621
Gyg -1550 -871 -3932 7223 -7057
Gys1 3871 7301 7419 1736 7330
Nhlrc1 5035 2482 3996 6493 2958
Ppp1r3c 3591 170 -4059 2676 -1046
Rps27a 2364 5541 -3759 -441 -3739
Uba52 4277 3662 1163 -7268 3243
Ubb 6745 2476 5259 1194 -3830
Ubc 2434 2920 4638 4179 3062



PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
metric value
setSize 11
pMANOVA 0.023
p.adjustMANOVA 0.0632
s.dist 0.633
s.hyp -0.101
s.amy -0.046
s.hip 0.294
s.pag -0.326
s.ni 0.442
p.hyp 0.563
p.amy 0.792
p.hip 0.0914
p.pag 0.061
p.ni 0.0111 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene ni pag
Cacna1a 5908 -6591
Cacng4 5699 -6610
Cacna1e 6682 -5621
Cacna1b 7317 -4849
Cacna2d2 5109 -4245
Cacng2 2794 -5582
Cacnb2 833 -4544

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Cacna1a 4200 3185 7496 -6591 5908
Cacna1b 1561 -1023 5990 -4849 7317
Cacna1e -3352 -4021 985 -5621 6682
Cacna2d2 -2370 804 2377 -4245 5109
Cacna2d3 -5728 -5200 -65 2785 383
Cacnb1 936 -2942 6192 2469 5416
Cacnb2 -4566 -3444 60 -4544 833
Cacnb3 6674 2261 6893 7739 5884
Cacnb4 -7863 -7029 -7337 -4552 -5716
Cacng2 -3816 6443 293 -5582 2794
Cacng4 4162 2726 6207 -6610 5699



ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
metric value
setSize 20
pMANOVA 0.000144
p.adjustMANOVA 0.000855
s.dist 0.629
s.hyp 0.342
s.amy 0.0541
s.hip 0.36
s.pag 0.359
s.ni -0.133
p.hyp 0.00812
p.amy 0.675
p.hip 0.00535
p.pag 0.00541
p.ni 0.302 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene hip pag
Tubb2a 7378 7623
Tubb4a 7975 7042
Tubb4b 7348 7140
Tuba1b 5655 7377
Tubb3 7359 5442
Tubb2b 5133 7029
Tuba1c 6857 4165
Tuba4a 4170 6754
Tuba1a 4047 6615
Prkab1 2458 5633
Prkag2 2218 5399
Tubb6 6359 1669
Prkag1 2958 1468

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Calm1 -7408 -6438 -7280 418 -6179
Camkk2 -3703 177 4412 -6295 2471
Mapt 5094 6079 5712 -4691 7771
Prkaa1 -5162 -6431 -6343 1423 -6319
Prkaa2 -6813 -7222 -5838 1236 -3675
Prkab1 1551 -5849 2458 5633 -2776
Prkab2 -3888 -5237 1796 -5242 6221
Prkag1 4465 5877 2958 1468 -129
Prkag2 139 -6667 2218 5399 -6373
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873



RHO GTPASES ACTIVATE IQGAPS

RHO GTPASES ACTIVATE IQGAPS
metric value
setSize 22
pMANOVA 0.000103
p.adjustMANOVA 0.000639
s.dist 0.626
s.hyp 0.27
s.amy 0.122
s.hip 0.298
s.pag 0.444
s.ni -0.133
p.hyp 0.0286
p.amy 0.323
p.hip 0.0154
p.pag 0.000312
p.ni 0.279 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene pag hip
Tubb2a 7623 7378
Tubb4a 7042 7975
Tubb4b 7140 7348
Tuba1b 7377 5655
Men1 5815 7162
Tubb3 5442 7359
Tubb2b 7029 5133
Tuba1c 4165 6857
Tuba4a 6754 4170
Tuba1a 6615 4047
Tubb6 1669 6359
Iqgap2 1982 4169
Ctnna1 7015 832
Actg1 1838 725

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Actb -6899 -2667 4643 -7405 -2370
Actg1 -2568 -3507 725 1838 -5668
Calm1 -7408 -6438 -7280 418 -6179
Cdc42 -6529 -6426 -7563 3373 -7442
Clip1 -279 923 -740 -4796 4904
Ctnna1 4897 7308 832 7015 3815
Ctnnb1 -2283 -4561 -2051 6367 1313
Iqgap1 -1462 4451 278 -551 7032
Iqgap2 -1681 1536 4169 1982 -2863
Men1 4160 2277 7162 5815 3304
Rac1 -3134 -6714 -4501 5612 -6665
Tuba1a 7304 -1416 4047 6615 -1549
Tuba1b 7288 3199 5655 7377 -4042
Tuba1c 2735 -474 6857 4165 -7350
Tuba4a 4780 2822 4170 6754 -3441
Tuba8 4395 692 955 -5027 -4552
Tubb2a 7422 936 7378 7623 790
Tubb2b 5998 573 5133 7029 3780
Tubb3 6704 6742 7359 5442 437
Tubb4a 6675 7115 7975 7042 4155
Tubb4b 7429 1199 7348 7140 -2380
Tubb6 6888 5268 6359 1669 4873



KERATAN SULFATE BIOSYNTHESIS

KERATAN SULFATE BIOSYNTHESIS
metric value
setSize 23
pMANOVA 0.000453
p.adjustMANOVA 0.00236
s.dist 0.625
s.hyp 0.325
s.amy 0.0249
s.hip 0.228
s.pag 0.481
s.ni -0.0476
p.hyp 0.00703
p.amy 0.836
p.hip 0.0588
p.pag 6.61e-05
p.ni 0.693 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene pag hyp
B4galt4 7626 7089
B4galt2 6604 7557
Prelp 7792 6112
St3gal4 5036 7547
Chst1 5340 5880
St3gal2 4465 6461
B4gat1 7371 3134
Fmod 3723 5558
Lum 3140 5480
B3gnt4 3873 3461
B4galt3 1879 6582
Chst2 6464 1737
Chst5 1367 5854
St3gal3 1733 3521
B4galt5 1507 2664
B3gnt7 2619 244

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Acan -3466 2599 4237 4892 3664
B3gnt2 -396 -3401 -2630 6029 -5636
B3gnt4 3461 -6952 2617 3873 137
B3gnt7 244 -5848 -3247 2619 -1608
B4galt1 -5685 -3628 5748 6752 418
B4galt2 7557 -82 5772 6604 -2463
B4galt3 6582 2911 4143 1879 295
B4galt4 7089 -833 -592 7626 -2313
B4galt5 2664 2971 7781 1507 6610
B4galt6 -3430 -7656 -6041 3883 -5794
B4gat1 3134 -1237 2112 7371 -2197
Chst1 5880 -1046 8043 5340 2217
Chst2 1737 2583 7413 6464 469
Chst5 5854 1205 2755 1367 405
Fmod 5558 6579 977 3723 1927
Lum 5480 -2421 -3571 3140 411
Ogn -414 6945 -3910 -1758 -1561
Prelp 6112 -1467 3702 7792 785
St3gal1 -1688 -7777 3745 2246 4676
St3gal2 6461 1625 6665 4465 3578
St3gal3 3521 6016 8215 1733 -120
St3gal4 7547 6504 1974 5036 -2329
St3gal6 -7287 -1850 -7243 -6980 -6914



SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
metric value
setSize 12
pMANOVA 0.0331
p.adjustMANOVA 0.0831
s.dist 0.622
s.hyp -0.0415
s.amy -0.0456
s.hip -0.452
s.pag 0.222
s.ni -0.36
p.hyp 0.804
p.amy 0.785
p.hip 0.00666
p.pag 0.183
p.ni 0.0308 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene hip ni
Spcs3 -7356 -7245
Pla2g7 -6775 -7591
Spcs2 -7495 -5753
Bche -5663 -5980
Spcs1 -5111 -5006
Sec11c -3317 -4200
Pcsk1 -6740 -662
Sec11a -3335 -531
Igf1 -6386 -171

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Ache 7556 6051 6900 5836 6932
Bche -7941 -8192 -5663 1913 -5980
Crhr2 6025 -2559 2995 -952 1445
Igf1 -5587 -5432 -6386 -4524 -171
Klf4 3821 6273 2803 5479 -3844
Pcsk1 5418 -1585 -6740 7409 -662
Pla2g7 -7971 -3439 -6775 -2719 -7591
Sec11a -201 3066 -3335 4438 -531
Sec11c -954 3943 -3317 -2746 -4200
Spcs1 2396 731 -5111 1558 -5006
Spcs2 -320 -1082 -7495 -57 -5753
Spcs3 -7674 -6721 -7356 4404 -7245



CYTOSOLIC TRNA AMINOACYLATION

CYTOSOLIC TRNA AMINOACYLATION
metric value
setSize 24
pMANOVA 6.09e-05
p.adjustMANOVA 0.000398
s.dist 0.62
s.hyp 0.354
s.amy 0.296
s.hip -0.0172
s.pag 0.386
s.ni -0.15
p.hyp 0.00272
p.amy 0.012
p.hip 0.884
p.pag 0.00107
p.ni 0.204 


Warning: Removed 396 rows containing missing values (`geom_tile()`).
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Top 20 genes
Gene pag hyp
Mars1 5884 7276
Aimp2 6952 5799
Yars 6183 5815
Hars 7781 4187
Farsb 6746 4765
Ppa1 6648 4809
Wars 5835 5389
Eef1e1 6255 4683
Qars 3940 5434
Aars 4728 4236
Gars 3559 2369
Kars 2594 2761

Click HERE to show all gene set members

All member genes
hyp amy hip pag ni
Aars 4236 3083 3280 4728 1853
Aimp1 4436 1300 -5186 -403 -5100
Aimp2 5799 5947 3558 6952 -3380
Cars 6207 5838 5396 -1681 4142
Dars -6162 -6890 -7510 2872 -7602
Eef1e1 4683 -1190 -6785 6255 -6378
Eprs -7347 2468 -3999 -2315 5521
Farsa 5841 4388 7398 -2932 4610
Farsb 4765 5956 2462 6746 -1375
Gars 2369 -3127 -2464 3559 -5004
Hars 4187 5894 -1925 7781 -3125
Iars -1417 3219 4264 4684 4806
Kars 2761 -271 1332 2594 -5118
Lars -6294 -1537 -3380 874 349
Mars1 7276 5858 7564 5884 5976
Nars -1183 175 -6065 1746 -3424
Ppa1 4809 3737 -4802 6648 -6568
Qars 5434 -3092 5397 3940 2133
Rars -11 -2853 -6374 6998 -5194
Sars 974 6266 -1570 -1890 580
Tars 5616 4311 -256 -1212 -6715
Vars 6292 89 7772 -2614 6504
Wars 5389 1656 5309 5835 -476
Yars 5815 6080 664 6183 -2112



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] progress_1.2.2          highr_0.10              later_1.3.1            
## [28] DelayedArray_0.26.7     reshape_0.8.9           BiocParallel_1.34.2    
## [31] prettyunits_1.1.1       parallel_4.3.1          R6_2.5.1               
## [34] bslib_0.5.1             stringi_1.7.12          RColorBrewer_1.1-3     
## [37] jquerylib_0.1.4         assertthat_0.2.1        Rcpp_1.0.11            
## [40] knitr_1.43              httpuv_1.6.11           Matrix_1.6-1           
## [43] timechange_0.2.0        tidyselect_1.2.0        rstudioapi_0.15.0      
## [46] abind_1.4-5             yaml_2.3.7              codetools_0.2-19       
## [49] lattice_0.21-8          plyr_1.8.8              shiny_1.7.5            
## [52] withr_2.5.0             evaluate_0.21           polyclip_1.10-4        
## [55] xml2_1.3.5              pillar_1.9.0            KernSmooth_2.23-22     
## [58] generics_0.1.3          RCurl_1.98-1.12         hms_1.1.3              
## [61] munsell_0.5.0           scales_1.2.1            xtable_1.8-4           
## [64] glue_1.6.2              tools_4.3.1             data.table_1.14.8      
## [67] webshot_0.5.5           locfit_1.5-9.8          fastmatch_1.1-4        
## [70] cowplot_1.1.1           grid_4.3.1              colorspace_2.1-0       
## [73] GenomeInfoDbData_1.2.10 cli_3.6.1               fansi_1.0.4            
## [76] viridisLite_0.4.2       S4Arrays_1.0.5          svglite_2.1.1          
## [79] gtable_0.3.4            sass_0.4.7              digest_0.6.33          
## [82] farver_2.1.1            htmlwidgets_1.6.2       htmltools_0.5.6        
## [85] lifecycle_1.0.3         httr_1.4.7              mime_0.12

END of report