Mitch Report

date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	hyp	amy	hip	pag	ni
0610009B22Rik	-0.3304181	0.2684894	-3.3814425	0.0259293	-2.3583781
0610009E02Rik	0.7596333	-0.7521235	-0.3557659	0.7519591	-0.4921631
0610009L18Rik	-1.2521412	-1.1838923	-0.8507498	-1.0644467	-1.5061599
0610010K14Rik	0.4193627	-0.0433030	1.2510787	0.4476085	-0.7608005
0610012G03Rik	1.4462155	-0.1930476	3.9729326	-0.1633199	-0.6314820
0610030E20Rik	-0.2426628	1.0496464	0.1581737	-0.6249661	1.2199694

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	15915
duplicated_genes_present	0
num_profile_genes_in_sets	8073
num_profile_genes_not_in_sets	7842

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	448
num_genesets_included	1156

Genes by sector

hyp	amy	hip	pag	ni	Count
-1	-1	-1	-1	-1	1567
1	-1	-1	-1	-1	267
-1	1	-1	-1	-1	444
1	1	-1	-1	-1	216
1	1	0	-1	-1	1
-1	-1	1	-1	-1	307
1	-1	1	-1	-1	292
-1	1	1	-1	-1	165
1	1	1	-1	-1	377
-1	-1	-1	1	-1	1746
1	-1	-1	1	-1	485
-1	1	-1	1	-1	332
1	1	-1	1	-1	358
-1	-1	1	1	-1	162
1	-1	1	1	-1	452
-1	1	1	1	-1	113
1	1	1	1	-1	527
1	1	-1	1	0	1
-1	-1	-1	-1	1	639
1	-1	-1	-1	1	133
-1	1	-1	-1	1	388
0	1	-1	-1	1	1
1	1	-1	-1	1	225
-1	-1	1	-1	1	626
1	-1	1	-1	1	410
-1	1	1	-1	1	628
1	1	1	-1	1	1368
1	1	1	0	1	1
-1	-1	-1	1	1	281
1	-1	-1	1	1	198
-1	1	-1	1	1	152
1	1	-1	1	1	217
-1	-1	1	1	1	243
1	-1	1	1	1	532
1	0	1	1	1	1
-1	1	1	1	1	287
1	1	1	1	1	1773

Number of significant gene sets (FDR<0.05)= 392

Gene sets by sector

Gene sets by sector

s.hyp	s.amy	s.hip	s.pag	s.ni	Count
-1	-1	-1	-1	-1	8
1	-1	-1	-1	-1	6
-1	1	-1	-1	-1	2
1	1	-1	-1	-1	25
-1	-1	1	-1	-1	2
1	-1	1	-1	-1	3
1	1	1	-1	-1	6
-1	-1	-1	1	-1	22
1	-1	-1	1	-1	33
-1	1	-1	1	-1	1
1	1	-1	1	-1	84
-1	-1	1	1	-1	8
1	-1	1	1	-1	17
-1	1	1	1	-1	5
1	1	1	1	-1	28
-1	-1	-1	-1	1	7
-1	1	-1	-1	1	1
1	1	-1	-1	1	1
-1	-1	1	-1	1	10
-1	1	1	-1	1	19
1	1	1	-1	1	17
-1	-1	-1	1	1	7
-1	1	-1	1	1	4
1	1	-1	1	1	3
-1	-1	1	1	1	27
1	-1	1	1	1	10
-1	1	1	1	1	15
1	1	1	1	1	21

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.hyp	s.amy	s.hip	s.pag	s.ni	p.hyp	p.amy	p.hip	p.pag	p.ni
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	1.76e-10	3.12e-09	1.010	0.5820	0.1560	0.1540	0.6950	-0.38300	1.11e-05	2.39e-01	0.244000	1.53e-07	3.84e-03
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	1.72e-05	1.27e-04	0.973	0.5930	0.3170	0.4490	0.5230	-0.13700	2.12e-04	4.80e-02	0.005070	1.09e-03	3.91e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	1.09e-06	1.03e-05	0.942	0.6300	0.3170	0.5030	0.3590	-0.08460	6.77e-06	2.38e-02	0.000328	1.04e-02	5.46e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.89e-04	1.09e-03	0.864	-0.0885	0.2080	0.4570	0.1620	0.67900	6.28e-01	2.55e-01	0.012400	3.76e-01	2.02e-04
CROSSLINKING OF COLLAGEN FIBRILS	13	1.77e-02	5.14e-02	0.833	0.3350	0.4010	0.5670	0.0343	0.31100	3.64e-02	1.22e-02	0.000397	8.30e-01	5.20e-02
MET ACTIVATES RAP1 AND RAC1	10	6.44e-02	1.39e-01	0.822	-0.3640	-0.5410	-0.3610	0.1330	-0.32200	4.64e-02	3.08e-03	0.048100	4.68e-01	7.80e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	5.12e-07	5.10e-06	0.798	0.5140	0.2590	0.3150	0.4230	-0.16700	2.01e-05	3.19e-02	0.008890	4.49e-04	1.65e-01
CD28 DEPENDENT VAV1 PATHWAY	11	2.59e-02	6.88e-02	0.790	-0.1270	-0.3170	-0.4380	0.3940	-0.40000	4.67e-01	6.86e-02	0.011800	2.36e-02	2.17e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	1.69e-02	4.98e-02	0.762	0.4100	0.4160	0.4380	-0.1400	0.16800	1.05e-02	9.35e-03	0.006250	3.81e-01	2.95e-01
ACTIVATION OF RAC1	13	2.13e-02	5.95e-02	0.759	-0.2230	-0.5010	-0.3740	0.2290	-0.28800	1.65e-01	1.76e-03	0.019500	1.53e-01	7.19e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	1.65e-02	4.89e-02	0.757	-0.3770	-0.4370	-0.3850	0.2700	-0.13800	3.04e-02	1.21e-02	0.026900	1.21e-01	4.28e-01
GAP JUNCTION ASSEMBLY	21	2.15e-05	1.54e-04	0.745	0.4380	0.2260	0.3200	0.4390	-0.13300	5.07e-04	7.28e-02	0.011200	5.02e-04	2.90e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.07e-05	8.38e-05	0.736	-0.0487	-0.2220	-0.4020	0.3230	-0.47400	6.50e-01	3.87e-02	0.000178	2.62e-03	9.91e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	2.18e-08	2.80e-07	0.733	0.3870	0.1650	0.0234	0.4610	-0.38400	6.46e-04	1.46e-01	0.836000	4.79e-05	6.95e-04
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.24e-03	9.26e-03	0.720	0.1520	0.3670	0.0551	0.5910	0.09840	3.61e-01	2.78e-02	0.741000	3.97e-04	5.55e-01
CGMP EFFECTS	15	3.70e-03	1.41e-02	0.717	-0.5600	-0.3020	-0.2270	-0.2410	0.01800	1.75e-04	4.31e-02	0.128000	1.06e-01	9.04e-01
REDUCTION OF CYTOSOLIC CA LEVELS	11	1.85e-02	5.29e-02	0.717	-0.5540	-0.3050	-0.2000	-0.2660	0.05780	1.46e-03	8.03e-02	0.252000	1.27e-01	7.40e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	1.94e-02	5.51e-02	0.715	-0.1100	-0.1520	-0.5270	0.0253	-0.44500	5.11e-01	3.62e-01	0.001580	8.79e-01	7.58e-03
PHASE 2 PLATEAU PHASE	10	1.07e-01	1.98e-01	0.706	0.1580	0.1610	0.3950	-0.1850	0.50700	3.87e-01	3.78e-01	0.030400	3.12e-01	5.53e-03
PROCESSING AND ACTIVATION OF SUMO	10	3.15e-02	7.95e-02	0.704	0.0186	-0.2960	-0.4770	0.2290	-0.35700	9.19e-01	1.05e-01	0.009030	2.09e-01	5.03e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	11	1.16e-02	3.66e-02	0.703	0.0315	-0.2520	-0.0582	0.5450	-0.35800	8.57e-01	1.48e-01	0.738000	1.74e-03	3.96e-02
RHOBTB3 ATPASE CYCLE	10	4.28e-02	1.00e-01	0.698	0.0102	-0.1460	-0.2390	0.5340	-0.35300	9.55e-01	4.24e-01	0.190000	3.48e-03	5.35e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	7.53e-02	1.54e-01	0.691	-0.0983	-0.2420	-0.3830	0.4120	-0.30400	5.90e-01	1.86e-01	0.036000	2.41e-02	9.57e-02
MATURATION OF NUCLEOPROTEIN	10	1.54e-01	2.61e-01	0.685	-0.3390	-0.1650	-0.3400	-0.3400	-0.31000	6.35e-02	3.67e-01	0.062300	6.27e-02	8.97e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	1.68e-04	9.70e-04	0.684	-0.1300	0.0211	0.2720	-0.2480	0.56100	3.52e-01	8.80e-01	0.052400	7.72e-02	6.15e-05
ACTIVATION OF SMO	16	5.51e-02	1.24e-01	0.676	0.2140	0.3000	0.4260	0.0957	0.36100	1.39e-01	3.79e-02	0.003200	5.08e-01	1.24e-02
IRE1ALPHA ACTIVATES CHAPERONES	49	6.89e-07	6.64e-06	0.675	0.4160	0.2180	0.2620	0.3540	0.20200	4.72e-07	8.41e-03	0.001540	1.83e-05	1.44e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	8.32e-08	9.61e-07	0.674	-0.2530	0.0476	0.2230	-0.2730	0.51300	2.28e-02	6.69e-01	0.044600	1.40e-02	3.87e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	11	4.86e-03	1.76e-02	0.673	0.0201	0.2150	0.4210	0.3850	0.28400	9.08e-01	2.16e-01	0.015600	2.71e-02	1.03e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	5.75e-03	2.00e-02	0.669	0.3090	0.1790	0.2880	0.2350	0.42600	1.66e-02	1.66e-01	0.025700	6.93e-02	9.70e-04
COHESIN LOADING ONTO CHROMATIN	10	9.90e-03	3.21e-02	0.667	-0.3420	0.1020	-0.5240	-0.1820	-0.09720	6.09e-02	5.77e-01	0.004120	3.19e-01	5.94e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	1.34e-01	2.36e-01	0.666	0.3270	0.4400	0.2760	-0.0869	0.24300	4.97e-02	8.27e-03	0.097400	6.02e-01	1.44e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.86e-05	1.36e-04	0.661	0.1690	0.1160	-0.2080	0.5170	-0.28900	1.61e-01	3.35e-01	0.083800	1.75e-05	1.65e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	5.12e-04	2.61e-03	0.658	-0.5130	-0.2720	-0.1960	-0.2250	0.08420	7.09e-05	3.55e-02	0.129000	8.17e-02	5.14e-01
AGGREPHAGY	34	3.96e-05	2.64e-04	0.656	0.4160	0.3300	0.2220	0.3140	0.02650	2.75e-05	8.58e-04	0.025100	1.52e-03	7.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	1.08e-02	3.46e-02	0.652	-0.0759	-0.2280	-0.3140	0.3110	-0.41400	5.67e-01	8.56e-02	0.017900	1.88e-02	1.78e-03
RETROGRADE NEUROTROPHIN SIGNALLING	12	1.12e-02	3.55e-02	0.650	0.2320	-0.0734	0.2630	0.5410	0.03430	1.64e-01	6.60e-01	0.115000	1.17e-03	8.37e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.68e-02	4.97e-02	0.650	-0.0646	-0.1390	-0.5130	0.0675	-0.36100	6.87e-01	3.85e-01	0.001350	6.74e-01	2.43e-02
INTERFERON ALPHA BETA SIGNALING	51	1.09e-08	1.46e-07	0.646	-0.2140	-0.3050	-0.1980	-0.3900	-0.29600	8.12e-03	1.69e-04	0.014500	1.49e-06	2.57e-04
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	2.45e-02	6.64e-02	0.638	0.4730	0.0655	0.1450	0.3960	0.02860	3.13e-03	6.83e-01	0.367000	1.34e-02	8.58e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	7.73e-04	3.68e-03	0.637	-0.2240	-0.0125	-0.3430	0.3790	-0.30700	8.34e-02	9.23e-01	0.008010	3.32e-03	1.75e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	13	4.40e-04	2.33e-03	0.636	0.0939	-0.3760	0.0607	0.0888	-0.49300	5.58e-01	1.88e-02	0.705000	5.79e-01	2.11e-03
EUKARYOTIC TRANSLATION ELONGATION	87	1.53e-38	5.91e-36	0.636	0.3030	0.4360	-0.1310	-0.1910	-0.26100	1.07e-06	2.01e-12	0.034700	2.06e-03	2.54e-05
GLYCOGEN STORAGE DISEASES	12	5.36e-02	1.21e-01	0.635	0.4120	0.1790	0.1020	0.4360	-0.00355	1.34e-02	2.83e-01	0.542000	8.89e-03	9.83e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	2.28e-02	6.29e-02	0.633	-0.1010	-0.0461	0.2940	-0.3260	0.44300	5.63e-01	7.91e-01	0.091100	6.09e-02	1.10e-02
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	1.42e-04	8.45e-04	0.630	0.3420	0.0542	0.3600	0.3590	-0.13300	8.12e-03	6.75e-01	0.005320	5.41e-03	3.02e-01
RHO GTPASES ACTIVATE IQGAPS	22	1.02e-04	6.35e-04	0.626	0.2700	0.1220	0.2980	0.4440	-0.13300	2.86e-02	3.23e-01	0.015400	3.11e-04	2.79e-01
KERATAN SULFATE BIOSYNTHESIS	23	4.50e-04	2.35e-03	0.626	0.3250	0.0249	0.2280	0.4810	-0.04760	7.02e-03	8.36e-01	0.058700	6.58e-05	6.93e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	3.30e-02	8.30e-02	0.623	-0.0414	-0.0456	-0.4520	0.2220	-0.36000	8.04e-01	7.84e-01	0.006660	1.83e-01	3.08e-02
CYTOSOLIC TRNA AMINOACYLATION	24	6.07e-05	3.96e-04	0.620	0.3540	0.2960	-0.0172	0.3860	-0.15000	2.71e-03	1.20e-02	0.884000	1.07e-03	2.03e-01

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Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.hyp	s.amy	s.hip	s.pag	s.ni	p.hyp	p.amy	p.hip	p.pag	p.ni
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	1.76e-10	3.12e-09	1.0100	0.582000	0.156000	1.54e-01	0.695000	-0.383000	1.11e-05	2.39e-01	2.44e-01	1.53e-07	3.84e-03
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	1.72e-05	1.27e-04	0.9730	0.593000	0.317000	4.49e-01	0.523000	-0.137000	2.12e-04	4.80e-02	5.07e-03	1.09e-03	3.91e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	1.09e-06	1.03e-05	0.9420	0.630000	0.317000	5.03e-01	0.359000	-0.084600	6.77e-06	2.38e-02	3.28e-04	1.04e-02	5.46e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.89e-04	1.09e-03	0.8640	-0.088500	0.208000	4.57e-01	0.162000	0.679000	6.28e-01	2.55e-01	1.24e-02	3.76e-01	2.02e-04
CROSSLINKING OF COLLAGEN FIBRILS	13	1.77e-02	5.14e-02	0.8330	0.335000	0.401000	5.67e-01	0.034300	0.311000	3.64e-02	1.22e-02	3.97e-04	8.30e-01	5.20e-02
MET ACTIVATES RAP1 AND RAC1	10	6.44e-02	1.39e-01	0.8220	-0.364000	-0.541000	-3.61e-01	0.133000	-0.322000	4.64e-02	3.08e-03	4.81e-02	4.68e-01	7.80e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	5.12e-07	5.10e-06	0.7980	0.514000	0.259000	3.15e-01	0.423000	-0.167000	2.01e-05	3.19e-02	8.89e-03	4.49e-04	1.65e-01
CD28 DEPENDENT VAV1 PATHWAY	11	2.59e-02	6.88e-02	0.7900	-0.127000	-0.317000	-4.38e-01	0.394000	-0.400000	4.67e-01	6.86e-02	1.18e-02	2.36e-02	2.17e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	1.69e-02	4.98e-02	0.7620	0.410000	0.416000	4.38e-01	-0.140000	0.168000	1.05e-02	9.35e-03	6.25e-03	3.81e-01	2.95e-01
ACTIVATION OF RAC1	13	2.13e-02	5.95e-02	0.7590	-0.223000	-0.501000	-3.74e-01	0.229000	-0.288000	1.65e-01	1.76e-03	1.95e-02	1.53e-01	7.19e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	1.65e-02	4.89e-02	0.7570	-0.377000	-0.437000	-3.85e-01	0.270000	-0.138000	3.04e-02	1.21e-02	2.69e-02	1.21e-01	4.28e-01
GAP JUNCTION ASSEMBLY	21	2.15e-05	1.54e-04	0.7450	0.438000	0.226000	3.20e-01	0.439000	-0.133000	5.07e-04	7.28e-02	1.12e-02	5.02e-04	2.90e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.07e-05	8.38e-05	0.7360	-0.048700	-0.222000	-4.02e-01	0.323000	-0.474000	6.50e-01	3.87e-02	1.78e-04	2.62e-03	9.91e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	2.18e-08	2.80e-07	0.7330	0.387000	0.165000	2.34e-02	0.461000	-0.384000	6.46e-04	1.46e-01	8.36e-01	4.79e-05	6.95e-04
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.24e-03	9.26e-03	0.7200	0.152000	0.367000	5.51e-02	0.591000	0.098400	3.61e-01	2.78e-02	7.41e-01	3.97e-04	5.55e-01
CGMP EFFECTS	15	3.70e-03	1.41e-02	0.7170	-0.560000	-0.302000	-2.27e-01	-0.241000	0.018000	1.75e-04	4.31e-02	1.28e-01	1.06e-01	9.04e-01
REDUCTION OF CYTOSOLIC CA LEVELS	11	1.85e-02	5.29e-02	0.7170	-0.554000	-0.305000	-2.00e-01	-0.266000	0.057800	1.46e-03	8.03e-02	2.52e-01	1.27e-01	7.40e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	1.94e-02	5.51e-02	0.7150	-0.110000	-0.152000	-5.27e-01	0.025300	-0.445000	5.11e-01	3.62e-01	1.58e-03	8.79e-01	7.58e-03
PHASE 2 PLATEAU PHASE	10	1.07e-01	1.98e-01	0.7060	0.158000	0.161000	3.95e-01	-0.185000	0.507000	3.87e-01	3.78e-01	3.04e-02	3.12e-01	5.53e-03
PROCESSING AND ACTIVATION OF SUMO	10	3.15e-02	7.95e-02	0.7040	0.018600	-0.296000	-4.77e-01	0.229000	-0.357000	9.19e-01	1.05e-01	9.03e-03	2.09e-01	5.03e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	11	1.16e-02	3.66e-02	0.7030	0.031500	-0.252000	-5.82e-02	0.545000	-0.358000	8.57e-01	1.48e-01	7.38e-01	1.74e-03	3.96e-02
RHOBTB3 ATPASE CYCLE	10	4.28e-02	1.00e-01	0.6980	0.010200	-0.146000	-2.39e-01	0.534000	-0.353000	9.55e-01	4.24e-01	1.90e-01	3.48e-03	5.35e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	7.53e-02	1.54e-01	0.6910	-0.098300	-0.242000	-3.83e-01	0.412000	-0.304000	5.90e-01	1.86e-01	3.60e-02	2.41e-02	9.57e-02
MATURATION OF NUCLEOPROTEIN	10	1.54e-01	2.61e-01	0.6850	-0.339000	-0.165000	-3.40e-01	-0.340000	-0.310000	6.35e-02	3.67e-01	6.23e-02	6.27e-02	8.97e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	1.68e-04	9.70e-04	0.6840	-0.130000	0.021100	2.72e-01	-0.248000	0.561000	3.52e-01	8.80e-01	5.24e-02	7.72e-02	6.15e-05
ACTIVATION OF SMO	16	5.51e-02	1.24e-01	0.6760	0.214000	0.300000	4.26e-01	0.095700	0.361000	1.39e-01	3.79e-02	3.20e-03	5.08e-01	1.24e-02
IRE1ALPHA ACTIVATES CHAPERONES	49	6.89e-07	6.64e-06	0.6750	0.416000	0.218000	2.62e-01	0.354000	0.202000	4.72e-07	8.41e-03	1.54e-03	1.83e-05	1.44e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	8.32e-08	9.61e-07	0.6740	-0.253000	0.047600	2.23e-01	-0.273000	0.513000	2.28e-02	6.69e-01	4.46e-02	1.40e-02	3.87e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	11	4.86e-03	1.76e-02	0.6730	0.020100	0.215000	4.21e-01	0.385000	0.284000	9.08e-01	2.16e-01	1.56e-02	2.71e-02	1.03e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	5.75e-03	2.00e-02	0.6690	0.309000	0.179000	2.88e-01	0.235000	0.426000	1.66e-02	1.66e-01	2.57e-02	6.93e-02	9.70e-04
COHESIN LOADING ONTO CHROMATIN	10	9.90e-03	3.21e-02	0.6670	-0.342000	0.102000	-5.24e-01	-0.182000	-0.097200	6.09e-02	5.77e-01	4.12e-03	3.19e-01	5.94e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	1.34e-01	2.36e-01	0.6660	0.327000	0.440000	2.76e-01	-0.086900	0.243000	4.97e-02	8.27e-03	9.74e-02	6.02e-01	1.44e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.86e-05	1.36e-04	0.6610	0.169000	0.116000	-2.08e-01	0.517000	-0.289000	1.61e-01	3.35e-01	8.38e-02	1.75e-05	1.65e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	5.12e-04	2.61e-03	0.6580	-0.513000	-0.272000	-1.96e-01	-0.225000	0.084200	7.09e-05	3.55e-02	1.29e-01	8.17e-02	5.14e-01
AGGREPHAGY	34	3.96e-05	2.64e-04	0.6560	0.416000	0.330000	2.22e-01	0.314000	0.026500	2.75e-05	8.58e-04	2.51e-02	1.52e-03	7.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	1.08e-02	3.46e-02	0.6520	-0.075900	-0.228000	-3.14e-01	0.311000	-0.414000	5.67e-01	8.56e-02	1.79e-02	1.88e-02	1.78e-03
RETROGRADE NEUROTROPHIN SIGNALLING	12	1.12e-02	3.55e-02	0.6500	0.232000	-0.073400	2.63e-01	0.541000	0.034300	1.64e-01	6.60e-01	1.15e-01	1.17e-03	8.37e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.68e-02	4.97e-02	0.6500	-0.064600	-0.139000	-5.13e-01	0.067500	-0.361000	6.87e-01	3.85e-01	1.35e-03	6.74e-01	2.43e-02
INTERFERON ALPHA BETA SIGNALING	51	1.09e-08	1.46e-07	0.6460	-0.214000	-0.305000	-1.98e-01	-0.390000	-0.296000	8.12e-03	1.69e-04	1.45e-02	1.49e-06	2.57e-04
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	2.45e-02	6.64e-02	0.6380	0.473000	0.065500	1.45e-01	0.396000	0.028600	3.13e-03	6.83e-01	3.67e-01	1.34e-02	8.58e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	7.73e-04	3.68e-03	0.6370	-0.224000	-0.012500	-3.43e-01	0.379000	-0.307000	8.34e-02	9.23e-01	8.01e-03	3.32e-03	1.75e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	13	4.40e-04	2.33e-03	0.6360	0.093900	-0.376000	6.07e-02	0.088800	-0.493000	5.58e-01	1.88e-02	7.05e-01	5.79e-01	2.11e-03
EUKARYOTIC TRANSLATION ELONGATION	87	1.53e-38	5.91e-36	0.6360	0.303000	0.436000	-1.31e-01	-0.191000	-0.261000	1.07e-06	2.01e-12	3.47e-02	2.06e-03	2.54e-05
GLYCOGEN STORAGE DISEASES	12	5.36e-02	1.21e-01	0.6350	0.412000	0.179000	1.02e-01	0.436000	-0.003550	1.34e-02	2.83e-01	5.42e-01	8.89e-03	9.83e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	2.28e-02	6.29e-02	0.6330	-0.101000	-0.046100	2.94e-01	-0.326000	0.443000	5.63e-01	7.91e-01	9.11e-02	6.09e-02	1.10e-02
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	1.42e-04	8.45e-04	0.6300	0.342000	0.054200	3.60e-01	0.359000	-0.133000	8.12e-03	6.75e-01	5.32e-03	5.41e-03	3.02e-01
RHO GTPASES ACTIVATE IQGAPS	22	1.02e-04	6.35e-04	0.6260	0.270000	0.122000	2.98e-01	0.444000	-0.133000	2.86e-02	3.23e-01	1.54e-02	3.11e-04	2.79e-01
KERATAN SULFATE BIOSYNTHESIS	23	4.50e-04	2.35e-03	0.6260	0.325000	0.024900	2.28e-01	0.481000	-0.047600	7.02e-03	8.36e-01	5.87e-02	6.58e-05	6.93e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	3.30e-02	8.30e-02	0.6230	-0.041400	-0.045600	-4.52e-01	0.222000	-0.360000	8.04e-01	7.84e-01	6.66e-03	1.83e-01	3.08e-02
CYTOSOLIC TRNA AMINOACYLATION	24	6.07e-05	3.96e-04	0.6200	0.354000	0.296000	-1.72e-02	0.386000	-0.150000	2.71e-03	1.20e-02	8.84e-01	1.07e-03	2.03e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	2.55e-02	6.83e-02	0.6150	0.199000	0.428000	2.71e-01	-0.140000	0.249000	1.23e-01	9.26e-04	3.56e-02	2.78e-01	5.41e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	2.08e-03	8.68e-03	0.6140	0.261000	0.092200	3.38e-01	0.200000	0.382000	2.12e-02	4.16e-01	2.82e-03	7.79e-02	7.39e-04
INTERLEUKIN 37 SIGNALING	17	3.88e-02	9.33e-02	0.6090	0.107000	0.392000	2.70e-01	0.065200	0.357000	4.44e-01	5.13e-03	5.36e-02	6.42e-01	1.07e-02
E2F MEDIATED REGULATION OF DNA REPLICATION	19	7.63e-02	1.55e-01	0.6030	-0.182000	-0.308000	-3.24e-01	0.161000	-0.325000	1.70e-01	2.03e-02	1.45e-02	2.24e-01	1.43e-02
INITIAL TRIGGERING OF COMPLEMENT	10	1.37e-01	2.38e-01	0.6020	0.064200	0.470000	1.92e-01	-0.003870	0.317000	7.25e-01	1.01e-02	2.93e-01	9.83e-01	8.27e-02
PROLONGED ERK ACTIVATION EVENTS	12	8.23e-02	1.64e-01	0.5930	-0.252000	-0.400000	-1.87e-01	0.260000	-0.163000	1.31e-01	1.64e-02	2.63e-01	1.20e-01	3.28e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	1.45e-01	2.49e-01	0.5930	0.352000	0.375000	2.63e-01	0.113000	0.072000	2.81e-02	1.91e-02	1.00e-01	4.80e-01	6.53e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.15e-03	1.85e-02	0.5890	-0.251000	-0.053400	-2.51e-01	0.167000	-0.435000	5.16e-02	6.79e-01	5.18e-02	1.95e-01	7.54e-04
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	2.28e-02	6.29e-02	0.5880	-0.214000	-0.534000	-1.10e-01	0.029100	0.036800	2.20e-01	2.15e-03	5.27e-01	8.67e-01	8.33e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	4.65e-13	1.28e-11	0.5860	0.326000	0.129000	-2.07e-01	0.196000	-0.373000	1.30e-04	1.31e-01	1.51e-02	2.16e-02	1.19e-05
G BETA GAMMA SIGNALLING THROUGH CDC42	18	7.46e-02	1.53e-01	0.5860	-0.134000	-0.228000	-3.01e-01	0.225000	-0.363000	3.25e-01	9.40e-02	2.69e-02	9.84e-02	7.70e-03
INSULIN PROCESSING	24	9.66e-05	6.04e-04	0.5840	-0.214000	-0.314000	-3.02e-01	0.325000	-0.015200	7.02e-02	7.83e-03	1.05e-02	5.82e-03	8.97e-01
LGI ADAM INTERACTIONS	14	9.82e-03	3.21e-02	0.5840	-0.102000	0.185000	2.84e-01	0.011500	0.463000	5.10e-01	2.30e-01	6.55e-02	9.41e-01	2.68e-03
KERATAN SULFATE KERATIN METABOLISM	29	2.89e-04	1.61e-03	0.5830	0.322000	0.035900	2.06e-01	0.438000	-0.024100	2.73e-03	7.38e-01	5.46e-02	4.50e-05	8.22e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	3.59e-02	8.91e-02	0.5810	0.029700	-0.042500	-2.28e-02	0.542000	-0.200000	8.59e-01	7.99e-01	8.91e-01	1.14e-03	2.30e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	8.81e-08	9.99e-07	0.5800	0.302000	0.167000	3.28e-02	0.446000	-0.131000	2.95e-04	4.58e-02	6.94e-01	9.17e-08	1.16e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	1.49e-01	2.54e-01	0.5780	0.009120	-0.168000	-2.24e-01	0.399000	-0.311000	9.58e-01	3.35e-01	1.98e-01	2.20e-02	7.41e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	65	2.13e-16	9.84e-15	0.5760	0.389000	0.142000	-5.31e-02	0.237000	-0.319000	5.73e-08	4.72e-02	4.59e-01	9.68e-04	8.98e-06
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	34	4.48e-04	2.35e-03	0.5760	0.383000	0.123000	3.22e-01	0.252000	0.054400	1.11e-04	2.14e-01	1.15e-03	1.11e-02	5.83e-01
CITRIC ACID CYCLE TCA CYCLE	22	1.07e-03	4.77e-03	0.5740	0.161000	0.081800	-1.47e-02	0.491000	-0.236000	1.91e-01	5.07e-01	9.05e-01	6.79e-05	5.49e-02
BRANCHED CHAIN AMINO ACID CATABOLISM	21	2.15e-03	8.94e-03	0.5730	0.087200	-0.004070	-2.36e-01	0.337000	-0.389000	4.89e-01	9.74e-01	6.16e-02	7.59e-03	2.01e-03
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	15	1.38e-01	2.39e-01	0.5710	0.300000	0.402000	2.02e-01	0.115000	0.142000	4.46e-02	6.98e-03	1.75e-01	4.41e-01	3.40e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	3.97e-02	9.43e-02	0.5710	-0.441000	-0.134000	-2.99e-01	0.156000	-0.006550	1.14e-02	4.41e-01	8.61e-02	3.70e-01	9.70e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.89e-02	7.51e-02	0.5670	-0.114000	0.072200	-1.99e-01	0.102000	-0.504000	5.11e-01	6.78e-01	2.54e-01	5.57e-01	3.82e-03
RECEPTOR MEDIATED MITOPHAGY	11	2.57e-02	6.87e-02	0.5670	-0.058100	0.023000	-3.88e-02	0.400000	-0.395000	7.39e-01	8.95e-01	8.24e-01	2.16e-02	2.34e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	60	2.43e-05	1.69e-04	0.5650	0.241000	0.356000	3.09e-01	-0.048800	0.192000	1.26e-03	1.80e-06	3.49e-05	5.14e-01	1.03e-02
METABOLISM OF POLYAMINES	57	1.33e-13	4.52e-12	0.5640	0.260000	0.071200	-2.27e-01	0.222000	-0.381000	7.03e-04	3.52e-01	3.00e-03	3.75e-03	6.51e-07
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	2.59e-33	4.27e-31	0.5630	0.231000	0.373000	-1.54e-01	-0.164000	-0.272000	1.06e-04	4.00e-10	9.96e-03	5.94e-03	5.38e-06
RAB GERANYLGERANYLATION	57	5.49e-06	4.60e-05	0.5630	-0.183000	-0.237000	-2.20e-01	0.249000	-0.341000	1.67e-02	1.97e-03	4.13e-03	1.14e-03	8.29e-06
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	4.21e-03	1.56e-02	0.5590	-0.257000	-0.244000	2.89e-01	0.031000	0.320000	1.59e-01	1.81e-01	1.13e-01	8.65e-01	7.94e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	1.49e-06	1.39e-05	0.5580	0.236000	0.084000	9.20e-02	0.474000	-0.125000	6.78e-03	3.35e-01	2.91e-01	5.45e-08	1.51e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	1.03e-01	1.94e-01	0.5560	-0.103000	-0.282000	-2.14e-01	0.321000	-0.266000	4.91e-01	5.86e-02	1.52e-01	3.13e-02	7.45e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	9.39e-04	4.32e-03	0.5560	0.337000	-0.093000	3.58e-02	0.383000	-0.197000	6.17e-03	4.50e-01	7.71e-01	1.86e-03	1.11e-01
SIGNALING BY FGFR4 IN DISEASE	10	3.87e-01	5.02e-01	0.5550	-0.371000	-0.197000	-3.34e-01	-0.098100	-0.104000	4.24e-02	2.81e-01	6.71e-02	5.91e-01	5.68e-01
SYNAPTIC ADHESION LIKE MOLECULES	21	2.48e-03	9.98e-03	0.5550	0.114000	-0.024000	3.59e-01	0.124000	0.388000	3.67e-01	8.49e-01	4.44e-03	3.26e-01	2.09e-03
COMPLEX I BIOGENESIS	56	4.87e-19	2.56e-17	0.5550	0.194000	0.289000	-1.51e-01	-0.205000	-0.349000	1.21e-02	1.86e-04	5.13e-02	7.94e-03	6.25e-06
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	1.67e-13	5.36e-12	0.5530	0.293000	0.071900	-2.02e-01	0.170000	-0.382000	2.00e-04	3.61e-01	1.03e-02	3.11e-02	1.21e-06
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	58	4.75e-13	1.28e-11	0.5510	0.280000	0.073800	-2.19e-01	0.256000	-0.326000	2.24e-04	3.31e-01	3.94e-03	7.32e-04	1.78e-05
CS DS DEGRADATION	14	4.13e-02	9.72e-02	0.5500	0.097100	0.266000	1.52e-01	0.364000	0.257000	5.30e-01	8.43e-02	3.25e-01	1.84e-02	9.57e-02
GAP JUNCTION TRAFFICKING AND REGULATION	33	1.27e-04	7.70e-04	0.5490	0.284000	0.183000	2.68e-01	0.332000	-0.074200	4.80e-03	6.90e-02	7.81e-03	9.59e-04	4.61e-01
DARPP 32 EVENTS	23	2.12e-02	5.95e-02	0.5490	-0.219000	-0.206000	-2.27e-01	0.275000	-0.289000	6.94e-02	8.72e-02	5.98e-02	2.23e-02	1.63e-02
SIGNALING BY LEPTIN	10	2.05e-01	3.19e-01	0.5480	0.276000	0.043900	2.39e-01	-0.059700	0.402000	1.31e-01	8.10e-01	1.91e-01	7.44e-01	2.77e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	5.21e-02	1.19e-01	0.5480	0.207000	0.090200	-4.79e-03	0.398000	-0.302000	2.14e-01	5.89e-01	9.77e-01	1.71e-02	7.06e-02
MITOCHONDRIAL TRANSLATION	93	1.58e-28	1.41e-26	0.5480	0.315000	0.213000	-5.48e-02	0.022700	-0.390000	1.56e-07	3.80e-04	3.62e-01	7.05e-01	8.44e-11
FGFR2 LIGAND BINDING AND ACTIVATION	10	1.35e-02	4.15e-02	0.5460	-0.005180	0.265000	-2.04e-01	-0.315000	-0.295000	9.77e-01	1.47e-01	2.64e-01	8.44e-02	1.06e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	5.58e-03	1.97e-02	0.5460	-0.080000	0.033600	2.64e-01	0.276000	0.381000	6.18e-01	8.34e-01	9.90e-02	8.52e-02	1.75e-02
INTERFERON GAMMA SIGNALING	71	2.15e-07	2.34e-06	0.5460	-0.232000	-0.231000	-1.89e-01	-0.308000	-0.246000	7.18e-04	7.86e-04	5.95e-03	7.01e-06	3.46e-04
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	9.41e-02	1.81e-01	0.5430	-0.335000	-0.225000	-2.83e-01	0.184000	-0.135000	2.45e-02	1.32e-01	5.76e-02	2.17e-01	3.64e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	1.76e-13	5.50e-12	0.5400	0.327000	0.147000	-1.57e-01	0.146000	-0.343000	3.76e-05	6.45e-02	4.85e-02	6.68e-02	1.60e-05
GLYCOGEN SYNTHESIS	14	3.07e-02	7.82e-02	0.5400	0.139000	0.095200	-1.91e-01	0.431000	-0.201000	3.66e-01	5.38e-01	2.16e-01	5.22e-03	1.92e-01
RORA ACTIVATES GENE EXPRESSION	18	1.84e-03	7.83e-03	0.5380	-0.235000	-0.004090	1.40e-01	-0.204000	0.415000	8.46e-02	9.76e-01	3.03e-01	1.34e-01	2.28e-03
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	12	1.85e-02	5.29e-02	0.5370	0.199000	0.050400	1.76e-01	0.347000	-0.309000	2.32e-01	7.62e-01	2.91e-01	3.75e-02	6.39e-02
KERATAN SULFATE DEGRADATION	11	2.10e-01	3.25e-01	0.5370	0.327000	0.204000	6.61e-02	0.357000	0.087300	6.05e-02	2.41e-01	7.04e-01	4.01e-02	6.16e-01
TIGHT JUNCTION INTERACTIONS	16	3.11e-02	7.87e-02	0.5350	-0.216000	-0.281000	-7.15e-02	0.141000	-0.368000	1.35e-01	5.15e-02	6.21e-01	3.31e-01	1.08e-02
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	8.12e-34	1.57e-31	0.5350	0.257000	0.317000	-1.76e-01	-0.079000	-0.287000	5.09e-06	1.65e-08	1.78e-03	1.60e-01	3.42e-07
COLLAGEN CHAIN TRIMERIZATION	38	2.92e-04	1.62e-03	0.5350	0.128000	0.391000	2.56e-01	-0.162000	0.156000	1.73e-01	2.99e-05	6.35e-03	8.34e-02	9.60e-02
HSF1 DEPENDENT TRANSACTIVATION	33	4.41e-03	1.61e-02	0.5340	0.249000	0.272000	2.48e-01	0.282000	0.084800	1.32e-02	6.82e-03	1.36e-02	5.03e-03	3.99e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	1.93e-07	2.12e-06	0.5330	-0.364000	-0.194000	-3.81e-02	0.229000	-0.245000	1.59e-04	4.40e-02	6.93e-01	1.73e-02	1.08e-02
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	1.20e-01	2.15e-01	0.5310	0.362000	0.059500	2.15e-01	0.133000	0.288000	1.89e-02	7.00e-01	1.63e-01	3.90e-01	6.19e-02
KINESINS	46	3.97e-04	2.15e-03	0.5310	0.225000	0.111000	3.04e-01	0.180000	0.308000	8.44e-03	1.93e-01	3.66e-04	3.52e-02	3.07e-04
SULFUR AMINO ACID METABOLISM	22	8.06e-04	3.79e-03	0.5300	0.197000	0.096600	1.07e-01	0.376000	-0.283000	1.09e-01	4.33e-01	3.84e-01	2.26e-03	2.16e-02
PEXOPHAGY	11	4.60e-01	5.70e-01	0.5260	0.255000	0.309000	2.97e-01	0.101000	0.135000	1.43e-01	7.60e-02	8.79e-02	5.64e-01	4.39e-01
PROTEIN UBIQUITINATION	69	4.85e-07	4.92e-06	0.5260	-0.044000	-0.138000	-2.95e-01	0.197000	-0.360000	5.28e-01	4.72e-02	2.23e-05	4.64e-03	2.33e-07
CRMPS IN SEMA3A SIGNALING	16	2.38e-02	6.53e-02	0.5250	0.077100	-0.082700	3.17e-01	-0.212000	0.344000	5.93e-01	5.67e-01	2.84e-02	1.43e-01	1.73e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	10	6.77e-02	1.43e-01	0.5240	0.175000	0.033200	1.07e-01	0.053900	0.478000	3.39e-01	8.56e-01	5.58e-01	7.68e-01	8.83e-03
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.73e-02	5.06e-02	0.5240	0.055100	0.222000	2.77e-01	-0.117000	0.363000	6.14e-01	4.22e-02	1.11e-02	2.83e-01	9.00e-04
NUCLEOBASE BIOSYNTHESIS	15	2.62e-02	6.92e-02	0.5230	0.042800	-0.050500	3.77e-02	0.489000	-0.171000	7.74e-01	7.35e-01	8.01e-01	1.05e-03	2.51e-01
PROTEIN METHYLATION	17	2.20e-02	6.11e-02	0.5220	0.092800	-0.002580	-2.67e-01	0.289000	-0.330000	5.08e-01	9.85e-01	5.68e-02	3.89e-02	1.84e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	5.77e-02	1.29e-01	0.5220	-0.279000	-0.176000	-2.35e-01	-0.292000	-0.150000	1.79e-02	1.36e-01	4.61e-02	1.32e-02	2.02e-01
MET ACTIVATES PTK2 SIGNALING	28	1.21e-02	3.77e-02	0.5200	0.052800	0.330000	1.96e-01	-0.150000	0.313000	6.29e-01	2.53e-03	7.25e-02	1.69e-01	4.13e-03
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	10	1.39e-02	4.25e-02	0.5170	-0.261000	-0.279000	2.54e-01	-0.050000	0.234000	1.54e-01	1.27e-01	1.65e-01	7.84e-01	2.01e-01
STABILIZATION OF P53	54	2.75e-12	6.63e-11	0.5160	0.315000	0.102000	-1.93e-01	0.169000	-0.302000	6.36e-05	1.97e-01	1.44e-02	3.21e-02	1.26e-04
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	9.67e-04	4.40e-03	0.5150	-0.045700	0.146000	3.15e-01	0.083400	0.369000	6.93e-01	2.06e-01	6.49e-03	4.71e-01	1.39e-03
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	1.19e-12	3.06e-11	0.5150	0.257000	0.083600	-1.81e-01	0.207000	-0.342000	4.14e-04	2.51e-01	1.29e-02	4.43e-03	2.77e-06
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	2.41e-01	3.60e-01	0.5150	0.141000	0.110000	3.58e-01	-0.031300	0.323000	3.62e-01	4.76e-01	2.03e-02	8.39e-01	3.65e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	8.15e-12	1.78e-10	0.5140	0.324000	0.118000	-1.42e-01	0.158000	-0.317000	4.55e-05	1.38e-01	7.30e-02	4.69e-02	6.65e-05
MITOTIC TELOPHASE CYTOKINESIS	13	6.42e-03	2.20e-02	0.5130	-0.214000	0.190000	-4.01e-01	-0.142000	0.015000	1.81e-01	2.37e-01	1.23e-02	3.76e-01	9.26e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	2.33e-03	9.57e-03	0.5120	0.260000	0.158000	1.88e-01	0.296000	0.216000	4.98e-03	8.78e-02	4.21e-02	1.38e-03	1.95e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	1.19e-01	2.14e-01	0.5110	0.186000	0.227000	-8.11e-03	0.334000	-0.252000	3.08e-01	2.14e-01	9.65e-01	6.77e-02	1.68e-01
INTRAFLAGELLAR TRANSPORT	49	4.49e-06	3.82e-05	0.5110	0.370000	0.073500	7.14e-02	0.329000	0.069300	7.33e-06	3.73e-01	3.88e-01	6.75e-05	4.02e-01
EARLY PHASE OF HIV LIFE CYCLE	13	3.81e-01	4.98e-01	0.5090	-0.186000	-0.128000	-3.39e-01	0.013600	-0.305000	2.47e-01	4.23e-01	3.42e-02	9.32e-01	5.68e-02
ASPARTATE AND ASPARAGINE METABOLISM	10	1.17e-01	2.13e-01	0.5080	-0.301000	0.007320	-1.87e-01	0.280000	-0.232000	9.98e-02	9.68e-01	3.06e-01	1.25e-01	2.04e-01
PYRUVATE METABOLISM	27	4.63e-02	1.07e-01	0.5070	-0.157000	-0.191000	-2.41e-01	0.190000	-0.320000	1.59e-01	8.54e-02	3.05e-02	8.69e-02	4.02e-03
EUKARYOTIC TRANSLATION INITIATION	114	2.26e-32	2.90e-30	0.5070	0.207000	0.299000	-1.71e-01	-0.082400	-0.297000	1.37e-04	3.51e-08	1.63e-03	1.29e-01	4.28e-08
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	29	2.32e-04	1.30e-03	0.5060	-0.224000	-0.072800	6.55e-02	-0.311000	0.315000	3.67e-02	4.97e-01	5.42e-01	3.72e-03	3.34e-03
RECYCLING PATHWAY OF L1	40	7.12e-05	4.52e-04	0.5060	0.222000	0.077500	2.67e-01	0.359000	-0.008510	1.49e-02	3.96e-01	3.50e-03	8.50e-05	9.26e-01
VOLTAGE GATED POTASSIUM CHANNELS	38	2.12e-10	3.72e-09	0.5060	-0.384000	-0.117000	1.37e-01	0.010700	0.274000	4.13e-05	2.11e-01	1.45e-01	9.09e-01	3.43e-03
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	4.71e-01	5.76e-01	0.5050	-0.315000	-0.192000	-3.29e-01	-0.005520	-0.105000	8.43e-02	2.94e-01	7.17e-02	9.76e-01	5.67e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	1.55e-14	5.99e-13	0.5050	0.165000	0.264000	-2.11e-01	0.037300	-0.336000	2.88e-02	4.60e-04	5.15e-03	6.21e-01	8.11e-06
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	1.74e-01	2.84e-01	0.5040	-0.273000	-0.150000	-1.47e-01	0.210000	-0.303000	1.01e-01	3.67e-01	3.79e-01	2.08e-01	6.95e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	9.16e-12	1.96e-10	0.5040	0.250000	0.046300	-1.92e-01	0.159000	-0.357000	8.96e-04	5.39e-01	1.09e-02	3.43e-02	2.13e-06
COLLAGEN FORMATION	75	3.73e-05	2.51e-04	0.5040	0.208000	0.309000	2.83e-01	-0.043600	0.181000	1.82e-03	3.83e-06	2.24e-05	5.14e-01	6.65e-03
HEDGEHOG LIGAND BIOGENESIS	61	4.19e-12	9.50e-11	0.5030	0.311000	0.131000	-1.56e-01	0.220000	-0.258000	2.60e-05	7.80e-02	3.50e-02	3.03e-03	4.92e-04
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	69	2.98e-14	1.11e-12	0.5030	0.272000	0.054600	-1.80e-01	0.157000	-0.346000	9.61e-05	4.33e-01	9.86e-03	2.42e-02	6.95e-07
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	13	1.79e-01	2.90e-01	0.5020	0.160000	0.301000	1.07e-01	0.216000	0.280000	3.19e-01	6.04e-02	5.02e-01	1.78e-01	8.10e-02
GLUTAMATE AND GLUTAMINE METABOLISM	13	2.31e-01	3.48e-01	0.5020	0.173000	0.292000	1.84e-01	0.298000	0.118000	2.80e-01	6.81e-02	2.50e-01	6.29e-02	4.62e-01
GLUCONEOGENESIS	27	2.63e-03	1.05e-02	0.5020	0.274000	0.127000	2.34e-01	0.309000	-0.100000	1.38e-02	2.55e-01	3.51e-02	5.38e-03	3.68e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	34	8.50e-04	3.96e-03	0.5010	-0.021800	-0.023200	-2.68e-01	0.298000	-0.300000	8.26e-01	8.15e-01	6.76e-03	2.66e-03	2.51e-03
NONSENSE MEDIATED DECAY NMD	109	3.62e-30	4.18e-28	0.5010	0.200000	0.346000	-1.36e-01	-0.170000	-0.209000	3.17e-04	4.37e-10	1.42e-02	2.13e-03	1.67e-04
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	9.85e-03	3.21e-02	0.5000	-0.373000	0.046500	-5.94e-02	0.235000	0.223000	4.11e-02	7.99e-01	7.45e-01	1.98e-01	2.22e-01
SELENOAMINO ACID METABOLISM	108	1.42e-29	1.37e-27	0.5000	0.240000	0.331000	-1.40e-01	-0.095100	-0.232000	1.65e-05	2.87e-09	1.21e-02	8.80e-02	3.09e-05
METHYLATION	11	8.01e-02	1.61e-01	0.4990	0.074400	0.120000	-2.58e-01	0.168000	-0.367000	6.69e-01	4.92e-01	1.39e-01	3.35e-01	3.53e-02
RMTS METHYLATE HISTONE ARGININES	41	2.74e-03	1.08e-02	0.4950	0.241000	0.243000	3.01e-01	-0.136000	0.138000	7.61e-03	7.17e-03	8.44e-04	1.32e-01	1.25e-01
DEGRADATION OF AXIN	53	2.48e-11	5.04e-10	0.4950	0.304000	0.090600	-1.66e-01	0.129000	-0.316000	1.30e-04	2.54e-01	3.63e-02	1.06e-01	6.87e-05
LYSOSPHINGOLIPID AND LPA RECEPTORS	11	4.13e-01	5.25e-01	0.4930	-0.292000	-0.327000	-1.47e-01	0.035600	-0.167000	9.32e-02	6.07e-02	3.98e-01	8.38e-01	3.39e-01
PENTOSE PHOSPHATE PATHWAY	13	1.35e-01	2.37e-01	0.4920	0.044900	-0.150000	-1.08e-01	0.241000	-0.384000	7.80e-01	3.48e-01	4.99e-01	1.32e-01	1.64e-02
RESPIRATORY ELECTRON TRANSPORT	102	1.81e-27	1.50e-25	0.4920	0.163000	0.203000	-1.13e-01	-0.151000	-0.372000	4.55e-03	3.88e-04	4.85e-02	8.31e-03	8.52e-11
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	7.02e-04	3.41e-03	0.4910	0.017600	0.005070	-2.95e-01	0.140000	-0.366000	8.66e-01	9.61e-01	4.44e-03	1.77e-01	4.15e-04
NCAM1 INTERACTIONS	39	2.16e-03	8.94e-03	0.4900	0.047800	0.182000	3.04e-01	-0.220000	0.254000	6.06e-01	4.97e-02	1.02e-03	1.77e-02	6.14e-03
DEGRADATION OF DVL	55	2.32e-11	4.79e-10	0.4900	0.282000	0.118000	-1.62e-01	0.129000	-0.322000	3.05e-04	1.30e-01	3.75e-02	9.84e-02	3.62e-05
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	4.18e-03	1.56e-02	0.4880	-0.299000	-0.338000	-4.38e-02	-0.043100	0.177000	2.83e-02	1.31e-02	7.48e-01	7.52e-01	1.93e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	59	2.91e-12	6.87e-11	0.4860	0.302000	0.079700	-1.38e-01	0.115000	-0.327000	6.21e-05	2.90e-01	6.65e-02	1.25e-01	1.40e-05
DEGRADATION OF GLI1 BY THE PROTEASOME	57	7.47e-11	1.39e-09	0.4860	0.271000	0.101000	-1.72e-01	0.170000	-0.307000	4.02e-04	1.89e-01	2.50e-02	2.61e-02	6.26e-05
VLDLR INTERNALISATION AND DEGRADATION	12	1.74e-01	2.84e-01	0.4850	0.238000	-0.059400	2.44e-01	0.330000	0.080700	1.53e-01	7.22e-01	1.44e-01	4.79e-02	6.29e-01
INTERLEUKIN 20 FAMILY SIGNALING	12	2.19e-01	3.35e-01	0.4840	0.326000	0.059800	2.03e-01	-0.096400	0.271000	5.03e-02	7.20e-01	2.22e-01	5.63e-01	1.03e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	9.57e-02	1.83e-01	0.4840	-0.252000	-0.395000	-9.31e-02	-0.015100	-0.075700	8.14e-02	6.17e-03	5.19e-01	9.17e-01	6.00e-01
TRIGLYCERIDE CATABOLISM	14	2.22e-01	3.37e-01	0.4840	-0.084200	-0.057700	-2.60e-01	0.210000	-0.335000	5.86e-01	7.09e-01	9.23e-02	1.75e-01	2.98e-02
CHOLESTEROL BIOSYNTHESIS	24	3.74e-04	2.04e-03	0.4830	0.290000	-0.098600	-1.93e-01	0.245000	-0.206000	1.38e-02	4.03e-01	1.01e-01	3.79e-02	8.11e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	20	2.05e-02	5.77e-02	0.4830	-0.317000	-0.310000	-5.78e-02	0.089800	-0.160000	1.42e-02	1.63e-02	6.55e-01	4.87e-01	2.17e-01
ANCHORING FIBRIL FORMATION	13	4.03e-01	5.17e-01	0.4820	0.070700	0.216000	2.44e-01	-0.177000	0.299000	6.59e-01	1.78e-01	1.28e-01	2.68e-01	6.16e-02
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	1.09e-02	3.47e-02	0.4810	0.339000	-0.008070	2.64e-01	0.174000	-0.130000	1.28e-02	9.53e-01	5.28e-02	2.01e-01	3.40e-01
SIGNALING BY FLT3 FUSION PROTEINS	18	3.22e-03	1.26e-02	0.4810	-0.200000	-0.234000	-2.86e-01	-0.152000	0.179000	1.42e-01	8.63e-02	3.60e-02	2.65e-01	1.88e-01
RUNX3 REGULATES NOTCH SIGNALING	13	3.66e-02	8.99e-02	0.4810	-0.180000	0.003920	2.85e-01	-0.128000	0.317000	2.60e-01	9.80e-01	7.51e-02	4.23e-01	4.77e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	80	1.52e-14	5.99e-13	0.4800	0.246000	0.029000	-1.95e-01	0.164000	-0.322000	1.43e-04	6.54e-01	2.54e-03	1.11e-02	6.49e-07
PRE NOTCH PROCESSING IN GOLGI	17	2.19e-01	3.35e-01	0.4790	0.138000	0.215000	3.25e-01	0.119000	0.211000	3.25e-01	1.26e-01	2.02e-02	3.97e-01	1.31e-01
GLUTATHIONE SYNTHESIS AND RECYCLING	11	9.37e-02	1.81e-01	0.4780	0.287000	0.142000	1.49e-01	0.203000	-0.249000	9.89e-02	4.15e-01	3.91e-01	2.43e-01	1.53e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	5.74e-01	6.61e-01	0.4750	-0.174000	-0.256000	-2.43e-01	0.120000	-0.238000	2.96e-01	1.25e-01	1.45e-01	4.72e-01	1.54e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	3.59e-02	8.91e-02	0.4740	0.099700	-0.170000	-2.19e-01	0.130000	-0.348000	4.52e-01	2.00e-01	9.82e-02	3.25e-01	8.60e-03
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	1.33e-02	4.10e-02	0.4730	-0.001320	0.338000	2.18e-01	0.128000	0.214000	9.91e-01	6.10e-03	7.64e-02	3.00e-01	8.19e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	1.04e-02	3.35e-02	0.4730	-0.180000	-0.231000	-2.16e-01	-0.229000	-0.197000	4.84e-02	1.14e-02	1.83e-02	1.23e-02	3.14e-02
P75NTR SIGNALS VIA NF KB	15	4.08e-01	5.20e-01	0.4710	0.208000	0.322000	2.03e-01	-0.036000	0.182000	1.63e-01	3.10e-02	1.74e-01	8.09e-01	2.23e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	2.12e-01	3.28e-01	0.4710	-0.146000	-0.172000	-2.20e-01	-0.256000	-0.239000	3.14e-01	2.33e-01	1.27e-01	7.59e-02	9.85e-02
GLYCOGEN METABOLISM	25	4.28e-03	1.57e-02	0.4710	0.155000	0.198000	-4.88e-02	0.392000	0.047300	1.80e-01	8.67e-02	6.73e-01	6.91e-04	6.82e-01
DERMATAN SULFATE BIOSYNTHESIS	11	1.94e-01	3.06e-01	0.4700	0.047100	0.188000	1.49e-01	0.308000	0.258000	7.87e-01	2.81e-01	3.94e-01	7.68e-02	1.38e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	50	5.51e-04	2.76e-03	0.4700	-0.055300	-0.105000	-2.68e-01	0.141000	-0.339000	4.99e-01	2.00e-01	1.05e-03	8.39e-02	3.37e-05
SCAVENGING BY CLASS A RECEPTORS	13	7.42e-02	1.53e-01	0.4700	0.151000	0.441000	1.73e-02	0.056400	0.013800	3.45e-01	5.95e-03	9.14e-01	7.25e-01	9.31e-01
INSULIN RECEPTOR RECYCLING	20	3.65e-02	8.99e-02	0.4700	0.073800	-0.107000	-8.14e-02	0.301000	-0.326000	5.68e-01	4.07e-01	5.29e-01	1.97e-02	1.16e-02
OLFACTORY SIGNALING PATHWAY	21	8.74e-03	2.93e-02	0.4690	-0.200000	-0.008610	-2.44e-01	-0.329000	0.111000	1.13e-01	9.46e-01	5.25e-02	9.11e-03	3.77e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	35	2.07e-03	8.65e-03	0.4690	0.167000	0.071800	3.48e-01	0.207000	0.152000	8.81e-02	4.62e-01	3.68e-04	3.37e-02	1.20e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	1.33e-01	2.35e-01	0.4690	0.160000	0.333000	2.13e-01	-0.040200	0.190000	1.74e-01	4.76e-03	7.08e-02	7.33e-01	1.08e-01
TRANSLATION	286	5.12e-62	5.91e-59	0.4680	0.263000	0.225000	-1.03e-01	0.063700	-0.290000	2.20e-14	6.20e-11	2.70e-03	6.45e-02	3.47e-17
CALNEXIN CALRETICULIN CYCLE	26	2.55e-03	1.02e-02	0.4670	0.076700	0.009150	-1.44e-01	0.436000	-0.038800	4.98e-01	9.36e-01	2.04e-01	1.21e-04	7.32e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	3.95e-02	9.40e-02	0.4660	-0.367000	-0.183000	-8.73e-02	-0.199000	-0.043400	2.31e-03	1.28e-01	4.69e-01	9.86e-02	7.19e-01
LDL CLEARANCE	16	1.20e-01	2.16e-01	0.4660	0.189000	0.041300	7.49e-02	0.418000	0.008950	1.91e-01	7.75e-01	6.04e-01	3.82e-03	9.51e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	1.01e-01	1.93e-01	0.4660	-0.185000	-0.228000	-2.03e-01	0.101000	-0.282000	8.41e-02	3.39e-02	5.91e-02	3.46e-01	8.65e-03
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	5.26e-02	1.19e-01	0.4660	0.075800	-0.195000	-2.15e-01	0.104000	-0.340000	5.68e-01	1.42e-01	1.04e-01	4.31e-01	1.02e-02
TRNA AMINOACYLATION	42	9.53e-04	4.36e-03	0.4650	0.305000	0.195000	6.67e-02	0.284000	-0.006230	6.17e-04	2.91e-02	4.55e-01	1.48e-03	9.44e-01
REPRESSION OF WNT TARGET GENES	14	7.09e-02	1.48e-01	0.4650	0.116000	0.233000	3.81e-01	-0.030400	0.043400	4.53e-01	1.31e-01	1.35e-02	8.44e-01	7.79e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	64	2.21e-09	3.31e-08	0.4640	0.148000	-0.025100	-1.91e-01	0.114000	-0.379000	4.13e-02	7.29e-01	8.17e-03	1.16e-01	1.59e-07
SUPPRESSION OF PHAGOSOMAL MATURATION	12	2.09e-01	3.25e-01	0.4640	0.149000	0.039000	-4.52e-02	0.372000	-0.225000	3.71e-01	8.15e-01	7.86e-01	2.56e-02	1.78e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	8.16e-02	1.63e-01	0.4630	0.162000	0.000952	-5.09e-02	0.268000	-0.337000	2.94e-01	9.95e-01	7.42e-01	8.30e-02	2.88e-02
REGULATION OF IFNG SIGNALING	13	6.59e-02	1.40e-01	0.4630	0.122000	-0.294000	-2.28e-01	0.210000	-0.128000	4.45e-01	6.61e-02	1.55e-01	1.89e-01	4.24e-01
FORMATION OF THE CORNIFIED ENVELOPE	22	3.80e-02	9.18e-02	0.4620	0.307000	0.057600	2.83e-01	0.190000	-0.007020	1.27e-02	6.40e-01	2.16e-02	1.23e-01	9.55e-01
KERATINIZATION	22	3.80e-02	9.18e-02	0.4620	0.307000	0.057600	2.83e-01	0.190000	-0.007020	1.27e-02	6.40e-01	2.16e-02	1.23e-01	9.55e-01
PROCESSING OF SMDT1	16	7.21e-02	1.49e-01	0.4620	0.140000	-0.178000	-1.95e-01	0.180000	-0.303000	3.34e-01	2.19e-01	1.76e-01	2.13e-01	3.59e-02
INTERLEUKIN 6 SIGNALING	10	2.32e-01	3.49e-01	0.4610	0.220000	-0.022900	1.57e-01	0.114000	0.355000	2.29e-01	9.00e-01	3.89e-01	5.32e-01	5.18e-02
NRAGE SIGNALS DEATH THROUGH JNK	54	1.85e-06	1.66e-05	0.4610	-0.043800	0.109000	3.39e-01	-0.063000	0.283000	5.78e-01	1.67e-01	1.65e-05	4.24e-01	3.23e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	1.15e-29	1.21e-27	0.4610	0.163000	0.209000	-1.01e-01	-0.124000	-0.342000	1.67e-03	5.56e-05	5.15e-02	1.70e-02	4.28e-11
N GLYCAN ANTENNAE ELONGATION	15	5.18e-02	1.18e-01	0.4600	-0.009020	-0.162000	5.88e-02	0.393000	-0.167000	9.52e-01	2.79e-01	6.93e-01	8.41e-03	2.64e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	2.55e-03	1.02e-02	0.4600	-0.099700	0.075200	1.78e-01	-0.228000	0.335000	3.29e-01	4.62e-01	8.09e-02	2.56e-02	1.04e-03
ECM PROTEOGLYCANS	64	1.52e-04	8.96e-04	0.4600	0.058500	0.300000	2.02e-01	-0.094800	0.261000	4.19e-01	3.34e-05	5.18e-03	1.90e-01	3.06e-04
PI 3K CASCADE FGFR2	15	1.09e-01	2.00e-01	0.4590	-0.217000	0.070100	-2.17e-01	-0.260000	-0.209000	1.46e-01	6.38e-01	1.45e-01	8.18e-02	1.60e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	34	4.77e-04	2.46e-03	0.4580	-0.099300	-0.056700	2.22e-01	-0.259000	0.284000	3.16e-01	5.67e-01	2.54e-02	8.97e-03	4.16e-03
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	49	4.08e-04	2.18e-03	0.4580	0.135000	0.335000	2.44e-01	-0.094200	0.104000	1.02e-01	5.02e-05	3.08e-03	2.54e-01	2.10e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	2.88e-01	4.11e-01	0.4570	0.177000	0.178000	2.55e-01	0.261000	0.113000	2.35e-01	2.34e-01	8.70e-02	7.96e-02	4.48e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	2.57e-11	5.12e-10	0.4570	0.120000	-0.039800	-2.06e-01	0.130000	-0.366000	5.43e-02	5.24e-01	9.52e-04	3.77e-02	4.60e-09
PHOSPHORYLATION OF THE APC C	17	2.24e-02	6.20e-02	0.4570	0.147000	-0.124000	-2.27e-01	0.028500	-0.345000	2.94e-01	3.76e-01	1.05e-01	8.39e-01	1.37e-02
ATTENUATION PHASE	23	1.36e-01	2.37e-01	0.4560	0.247000	0.262000	1.58e-01	0.219000	0.074500	4.02e-02	2.95e-02	1.90e-01	6.94e-02	5.36e-01
MITOCHONDRIAL PROTEIN IMPORT	63	6.41e-11	1.21e-09	0.4560	0.261000	0.093900	-2.20e-02	0.133000	-0.336000	3.47e-04	1.98e-01	7.63e-01	6.78e-02	4.03e-06
ORC1 REMOVAL FROM CHROMATIN	67	4.08e-09	5.97e-08	0.4560	0.131000	-0.005150	-2.10e-01	0.133000	-0.359000	6.31e-02	9.42e-01	2.93e-03	6.01e-02	3.88e-07
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	12	6.53e-02	1.39e-01	0.4550	-0.204000	-0.042400	2.59e-01	-0.165000	0.262000	2.21e-01	7.99e-01	1.20e-01	3.21e-01	1.16e-01
PHASE 0 RAPID DEPOLARISATION	28	1.13e-04	6.92e-04	0.4540	-0.324000	-0.136000	9.39e-02	-0.128000	0.240000	3.02e-03	2.14e-01	3.90e-01	2.40e-01	2.82e-02
UNWINDING OF DNA	12	1.02e-01	1.94e-01	0.4520	-0.070200	-0.219000	1.09e-02	0.109000	-0.374000	6.74e-01	1.89e-01	9.48e-01	5.12e-01	2.50e-02
FERTILIZATION	12	1.29e-01	2.29e-01	0.4510	-0.090000	0.317000	-2.29e-02	-0.233000	0.200000	5.89e-01	5.71e-02	8.91e-01	1.63e-01	2.31e-01
SODIUM CALCIUM EXCHANGERS	10	4.28e-01	5.39e-01	0.4500	-0.379000	-0.175000	-1.38e-01	-0.087000	-0.028700	3.77e-02	3.37e-01	4.51e-01	6.34e-01	8.75e-01
PURINE SALVAGE	12	2.55e-01	3.75e-01	0.4490	0.128000	-0.002210	-9.13e-02	0.399000	-0.133000	4.41e-01	9.89e-01	5.84e-01	1.67e-02	4.23e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	5.55e-04	2.77e-03	0.4480	0.185000	0.025700	-6.60e-02	0.203000	-0.347000	7.89e-02	8.07e-01	5.32e-01	5.46e-02	9.95e-04
REGULATION OF EXPRESSION OF SLITS AND ROBOS	160	4.69e-35	1.08e-32	0.4480	0.219000	0.261000	-1.50e-01	-0.034800	-0.247000	1.86e-06	1.30e-08	1.05e-03	4.48e-01	7.36e-08
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	11	3.61e-01	4.82e-01	0.4470	0.104000	0.295000	9.80e-02	0.203000	0.225000	5.49e-01	9.06e-02	5.73e-01	2.43e-01	1.96e-01
CRISTAE FORMATION	31	2.63e-05	1.81e-04	0.4460	0.135000	0.126000	-1.18e-01	0.035200	-0.387000	1.94e-01	2.23e-01	2.54e-01	7.35e-01	1.95e-04
INTERLEUKIN 12 SIGNALING	36	1.52e-03	6.54e-03	0.4460	0.035900	-0.016600	-2.42e-01	0.167000	-0.333000	7.09e-01	8.63e-01	1.21e-02	8.27e-02	5.51e-04
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	2.20e-01	3.35e-01	0.4440	0.055000	0.120000	2.85e-01	0.110000	0.293000	7.12e-01	4.23e-01	5.61e-02	4.60e-01	4.92e-02
REGULATION OF PTEN STABILITY AND ACTIVITY	66	1.17e-09	1.85e-08	0.4430	0.236000	0.062200	-1.56e-01	0.186000	-0.279000	9.00e-04	3.83e-01	2.81e-02	8.94e-03	9.09e-05
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	10	7.57e-02	1.55e-01	0.4430	-0.045800	0.304000	-8.64e-02	-0.228000	-0.206000	8.02e-01	9.65e-02	6.36e-01	2.11e-01	2.60e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	90	4.49e-09	6.48e-08	0.4430	0.211000	-0.006470	1.56e-01	0.350000	-0.068300	5.47e-04	9.16e-01	1.07e-02	9.27e-09	2.63e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	4.60e-11	9.02e-10	0.4420	0.193000	0.021400	-1.50e-01	0.202000	-0.307000	2.24e-03	7.35e-01	1.73e-02	1.36e-03	1.19e-06
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	7.71e-04	3.68e-03	0.4420	0.114000	0.021700	-1.33e-01	0.400000	-0.064300	2.42e-01	8.24e-01	1.75e-01	4.23e-05	5.11e-01
PI 3K CASCADE FGFR4	10	3.39e-01	4.62e-01	0.4410	-0.258000	0.045000	-2.94e-01	-0.194000	-0.045100	1.57e-01	8.06e-01	1.07e-01	2.89e-01	8.05e-01
HDMS DEMETHYLATE HISTONES	26	5.38e-03	1.91e-02	0.4410	-0.238000	-0.090800	1.21e-01	-0.311000	0.135000	3.56e-02	4.23e-01	2.85e-01	6.12e-03	2.34e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	3.93e-01	5.07e-01	0.4410	-0.243000	-0.180000	-2.95e-01	0.102000	-0.072500	1.44e-01	2.81e-01	7.69e-02	5.39e-01	6.64e-01
JOSEPHIN DOMAIN DUBS	11	3.83e-01	4.99e-01	0.4400	0.283000	0.297000	1.24e-01	0.098200	-0.024900	1.04e-01	8.85e-02	4.77e-01	5.73e-01	8.86e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	19	5.41e-02	1.22e-01	0.4400	0.060200	-0.206000	-8.43e-03	0.361000	-0.133000	6.50e-01	1.21e-01	9.49e-01	6.49e-03	3.17e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	1.58e-01	2.67e-01	0.4400	0.053600	-0.157000	-2.23e-01	0.341000	0.010800	7.69e-01	3.91e-01	2.23e-01	6.16e-02	9.53e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	10	4.22e-01	5.33e-01	0.4400	-0.340000	-0.116000	-5.33e-02	-0.245000	-0.032700	6.24e-02	5.24e-01	7.70e-01	1.79e-01	8.58e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	12	1.37e-01	2.38e-01	0.4400	0.245000	0.018500	3.13e-01	-0.185000	0.032600	1.42e-01	9.12e-01	6.09e-02	2.66e-01	8.45e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	5.55e-02	1.24e-01	0.4400	-0.032700	0.080300	3.13e-01	-0.133000	0.265000	8.00e-01	5.34e-01	1.54e-02	3.03e-01	4.05e-02
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	2.35e-02	6.45e-02	0.4390	0.193000	0.279000	1.13e-01	-0.129000	-0.221000	2.29e-01	8.20e-02	4.81e-01	4.20e-01	1.69e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	3.89e-01	5.03e-01	0.4360	0.162000	-0.039300	9.58e-02	0.392000	0.006970	3.76e-01	8.30e-01	6.00e-01	3.19e-02	9.70e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	2.35e-03	9.57e-03	0.4360	-0.198000	-0.071000	1.64e-01	-0.129000	-0.320000	2.01e-01	6.45e-01	2.89e-01	4.02e-01	3.80e-02
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	7.00e-02	1.46e-01	0.4360	0.039900	0.046200	1.79e-01	0.235000	0.315000	7.83e-01	7.49e-01	2.15e-01	1.04e-01	2.92e-02
SYNTHESIS OF PE	12	2.78e-01	4.00e-01	0.4350	0.188000	-0.030300	1.91e-01	0.244000	0.239000	2.60e-01	8.56e-01	2.53e-01	1.43e-01	1.51e-01
HSF1 ACTIVATION	25	2.40e-02	6.56e-02	0.4350	0.257000	0.124000	2.66e-02	0.297000	-0.138000	2.59e-02	2.82e-01	8.18e-01	1.02e-02	2.33e-01
PI3K EVENTS IN ERBB2 SIGNALING	14	1.81e-01	2.92e-01	0.4350	-0.375000	-0.118000	-6.42e-02	-0.176000	0.002640	1.53e-02	4.46e-01	6.77e-01	2.53e-01	9.86e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	1.37e-02	4.18e-02	0.4330	-0.077900	0.069900	3.41e-01	-0.244000	0.027900	6.01e-01	6.39e-01	2.20e-02	1.02e-01	8.51e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	5.23e-02	1.19e-01	0.4330	-0.234000	-0.018900	1.15e-01	-0.069300	0.338000	1.45e-01	9.06e-01	4.73e-01	6.65e-01	3.49e-02
GLYCOSPHINGOLIPID METABOLISM	38	9.27e-04	4.30e-03	0.4330	0.115000	-0.030700	6.43e-02	0.385000	-0.143000	2.21e-01	7.43e-01	4.93e-01	4.01e-05	1.26e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	6.75e-02	1.43e-01	0.4320	0.025500	0.179000	-5.36e-02	0.371000	0.118000	8.69e-01	2.46e-01	7.29e-01	1.63e-02	4.43e-01
RAP1 SIGNALLING	15	1.02e-01	1.93e-01	0.4320	-0.193000	-0.245000	-7.80e-02	0.283000	-0.062100	1.97e-01	1.01e-01	6.01e-01	5.81e-02	6.77e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	21	5.97e-02	1.32e-01	0.4320	0.213000	-0.042000	6.37e-02	0.351000	-0.111000	9.15e-02	7.39e-01	6.13e-01	5.36e-03	3.78e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	2.63e-01	3.85e-01	0.4320	-0.332000	-0.273000	-2.72e-03	-0.041800	-0.013900	6.93e-02	1.35e-01	9.88e-01	8.19e-01	9.39e-01
KILLING MECHANISMS	10	3.42e-01	4.63e-01	0.4320	0.122000	0.108000	1.54e-01	-0.359000	0.083600	5.04e-01	5.54e-01	3.98e-01	4.94e-02	6.47e-01
DNA REPLICATION PRE INITIATION	79	1.90e-09	2.92e-08	0.4310	0.140000	-0.036100	-1.83e-01	0.139000	-0.335000	3.19e-02	5.79e-01	4.85e-03	3.31e-02	2.61e-07
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	23	1.33e-01	2.35e-01	0.4310	-0.068800	-0.109000	-2.85e-01	0.023000	-0.296000	5.68e-01	3.68e-01	1.79e-02	8.49e-01	1.41e-02
FATTY ACYL COA BIOSYNTHESIS	32	2.49e-03	1.00e-02	0.4310	-0.097300	0.050400	-1.92e-01	0.323000	-0.179000	3.41e-01	6.22e-01	5.97e-02	1.57e-03	7.91e-02
INTERFERON SIGNALING	158	5.71e-09	8.05e-08	0.4300	-0.206000	-0.198000	-1.60e-01	-0.206000	-0.187000	8.04e-06	1.74e-05	5.25e-04	7.79e-06	5.23e-05
FORMATION OF APOPTOSOME	10	5.96e-01	6.80e-01	0.4290	-0.104000	-0.160000	-1.50e-01	0.237000	-0.262000	5.69e-01	3.82e-01	4.11e-01	1.94e-01	1.51e-01
AMINE LIGAND BINDING RECEPTORS	27	1.22e-05	9.41e-05	0.4290	-0.233000	-0.248000	1.80e-01	0.181000	0.049500	3.59e-02	2.56e-02	1.05e-01	1.03e-01	6.56e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	4.81e-01	5.85e-01	0.4280	0.257000	0.182000	2.28e-01	-0.018000	0.178000	5.94e-02	1.81e-01	9.46e-02	8.95e-01	1.91e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	2.32e-01	3.49e-01	0.4280	0.030500	-0.087800	-1.98e-01	0.201000	-0.307000	8.33e-01	5.43e-01	1.70e-01	1.64e-01	3.33e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	28	3.47e-03	1.34e-02	0.4280	0.128000	-0.170000	-1.68e-01	0.043300	-0.328000	2.40e-01	1.20e-01	1.24e-01	6.92e-01	2.68e-03
BUDDING AND MATURATION OF HIV VIRION	27	4.99e-03	1.80e-02	0.4270	0.201000	0.045100	-2.01e-02	0.242000	-0.284000	7.09e-02	6.85e-01	8.57e-01	2.93e-02	1.06e-02
CELLULAR HEXOSE TRANSPORT	11	6.53e-02	1.39e-01	0.4270	0.102000	-0.175000	3.71e-01	0.011700	0.055100	5.56e-01	3.16e-01	3.29e-02	9.47e-01	7.52e-01
HS GAG DEGRADATION	20	4.05e-02	9.58e-02	0.4260	0.290000	-0.017100	1.32e-01	0.096600	0.265000	2.48e-02	8.95e-01	3.06e-01	4.55e-01	4.01e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	3.58e-03	1.38e-02	0.4260	0.127000	0.150000	-9.23e-02	-0.101000	-0.352000	3.49e-01	2.69e-01	4.98e-01	4.57e-01	9.78e-03
LAMININ INTERACTIONS	27	2.44e-02	6.64e-02	0.4260	-0.084800	0.158000	2.03e-01	-0.254000	0.208000	4.46e-01	1.56e-01	6.79e-02	2.22e-02	6.19e-02
BIOTIN TRANSPORT AND METABOLISM	11	6.34e-01	7.12e-01	0.4250	0.174000	0.242000	2.31e-01	-0.136000	0.142000	3.18e-01	1.65e-01	1.84e-01	4.33e-01	4.15e-01
PYRIMIDINE SALVAGE	10	1.04e-01	1.95e-01	0.4240	0.248000	-0.290000	1.37e-01	0.091400	0.081800	1.74e-01	1.12e-01	4.52e-01	6.17e-01	6.54e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	4.70e-01	5.76e-01	0.4240	-0.219000	-0.164000	-4.06e-02	-0.277000	-0.162000	2.31e-01	3.68e-01	8.24e-01	1.29e-01	3.74e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	1.46e-02	4.42e-02	0.4240	0.065300	-0.089900	-5.12e-02	0.233000	-0.332000	5.64e-01	4.27e-01	6.51e-01	3.95e-02	3.40e-03
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	4.24e-01	5.35e-01	0.4230	0.192000	0.058200	7.59e-02	0.349000	0.106000	2.69e-01	7.38e-01	6.63e-01	4.49e-02	5.44e-01
G1 S DNA DAMAGE CHECKPOINTS	65	1.46e-09	2.28e-08	0.4220	0.242000	0.079300	-1.70e-01	0.144000	-0.254000	7.61e-04	2.69e-01	1.81e-02	4.48e-02	4.06e-04
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	2.52e-02	6.77e-02	0.4220	-0.311000	0.029900	-2.92e-02	0.273000	-0.073200	5.23e-02	8.52e-01	8.55e-01	8.86e-02	6.48e-01
GABA RECEPTOR ACTIVATION	52	4.24e-05	2.82e-04	0.4220	-0.204000	-0.201000	-1.81e-01	0.248000	-0.035300	1.08e-02	1.20e-02	2.38e-02	1.97e-03	6.60e-01
DISEASES OF CARBOHYDRATE METABOLISM	28	6.81e-02	1.44e-01	0.4210	0.335000	0.106000	1.47e-01	0.168000	0.064000	2.18e-03	3.31e-01	1.77e-01	1.24e-01	5.58e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	6.54e-05	4.18e-04	0.4210	0.152000	0.100000	-1.15e-01	0.350000	-0.091900	6.59e-02	2.26e-01	1.65e-01	2.28e-05	2.66e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	2.44e-03	9.88e-03	0.4200	0.150000	-0.175000	1.59e-01	0.309000	-0.051200	1.62e-01	1.03e-01	1.39e-01	4.01e-03	6.34e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	1.66e-01	2.75e-01	0.4200	-0.176000	-0.231000	-1.86e-01	-0.052100	-0.233000	7.94e-02	2.15e-02	6.42e-02	6.04e-01	2.07e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	3.16e-02	7.97e-02	0.4170	0.185000	-0.150000	-1.60e-01	0.114000	-0.280000	1.63e-01	2.57e-01	2.26e-01	3.91e-01	3.43e-02
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	17	1.93e-01	3.05e-01	0.4170	0.057200	-0.090000	-1.17e-01	0.256000	-0.288000	6.83e-01	5.21e-01	4.02e-01	6.79e-02	3.95e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	2.43e-09	3.60e-08	0.4160	0.316000	0.076600	-7.37e-02	0.106000	-0.226000	1.71e-05	2.97e-01	3.16e-01	1.49e-01	2.09e-03
HEME SIGNALING	44	5.24e-04	2.63e-03	0.4150	-0.295000	-0.154000	-4.33e-02	-0.214000	0.119000	7.17e-04	7.77e-02	6.19e-01	1.39e-02	1.73e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	1.03e-02	3.32e-02	0.4150	-0.197000	-0.224000	-4.59e-02	0.102000	-0.266000	5.79e-02	3.07e-02	6.58e-01	3.26e-01	1.03e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	12	1.63e-01	2.71e-01	0.4150	0.177000	0.250000	-8.45e-02	0.202000	-0.174000	2.89e-01	1.33e-01	6.12e-01	2.25e-01	2.97e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	2.14e-08	2.78e-07	0.4140	0.133000	0.003840	-2.02e-01	0.181000	-0.284000	4.31e-02	9.53e-01	2.01e-03	5.75e-03	1.51e-05
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	4.67e-01	5.74e-01	0.4140	-0.176000	-0.195000	-2.03e-01	0.183000	-0.167000	2.37e-01	1.92e-01	1.73e-01	2.20e-01	2.63e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	1.61e-02	4.80e-02	0.4140	0.091300	-0.018600	-1.70e-01	-0.049600	-0.363000	4.80e-01	8.86e-01	1.87e-01	7.01e-01	5.00e-03
ELASTIC FIBRE FORMATION	35	4.28e-02	1.00e-01	0.4130	0.102000	0.305000	2.15e-01	-0.011800	0.145000	2.97e-01	1.82e-03	2.77e-02	9.04e-01	1.37e-01
S PHASE	153	3.29e-14	1.19e-12	0.4130	0.054500	-0.066300	-2.07e-01	0.105000	-0.331000	2.45e-01	1.58e-01	1.00e-05	2.54e-02	1.74e-12
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	7.79e-04	3.69e-03	0.4130	-0.016200	-0.068300	-1.19e-01	0.301000	-0.247000	8.41e-01	3.99e-01	1.42e-01	2.03e-04	2.32e-03
CELLULAR RESPONSE TO HYPOXIA	71	8.49e-10	1.38e-08	0.4130	0.211000	0.073800	-1.47e-01	0.117000	-0.292000	2.12e-03	2.82e-01	3.28e-02	8.74e-02	2.18e-05
LYSINE CATABOLISM	10	4.85e-01	5.87e-01	0.4120	0.130000	0.133000	9.09e-02	0.297000	0.198000	4.75e-01	4.68e-01	6.19e-01	1.04e-01	2.78e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	11	6.81e-01	7.48e-01	0.4120	-0.182000	-0.292000	-1.93e-01	-0.049500	-0.107000	2.95e-01	9.30e-02	2.69e-01	7.76e-01	5.38e-01
DNA REPLICATION	121	2.65e-13	8.05e-12	0.4120	0.122000	-0.047800	-1.78e-01	0.113000	-0.328000	2.07e-02	3.64e-01	7.21e-04	3.21e-02	4.58e-10
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	3.05e-03	1.19e-02	0.4120	0.191000	-0.053100	1.69e-01	0.277000	-0.158000	7.07e-02	6.15e-01	1.09e-01	8.67e-03	1.35e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	48	1.03e-03	4.58e-03	0.4110	0.037800	0.022400	2.70e-01	-0.060400	0.302000	6.50e-01	7.88e-01	1.22e-03	4.69e-01	3.02e-04
SELECTIVE AUTOPHAGY	71	1.33e-05	1.02e-04	0.4110	0.227000	0.162000	8.67e-02	0.275000	-0.093300	9.71e-04	1.82e-02	2.07e-01	6.32e-05	1.74e-01
FCERI MEDIATED NF KB ACTIVATION	76	5.64e-09	8.05e-08	0.4110	0.180000	0.050700	-1.63e-01	0.180000	-0.274000	6.71e-03	4.45e-01	1.40e-02	6.74e-03	3.58e-05
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	28	1.16e-02	3.66e-02	0.4110	0.044800	-0.098300	-1.81e-01	-0.009810	-0.353000	6.81e-01	3.68e-01	9.76e-02	9.28e-01	1.23e-03
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	3.50e-03	1.35e-02	0.4100	0.237000	0.046300	-2.42e-02	0.322000	-0.073400	1.13e-02	6.21e-01	7.96e-01	5.92e-04	4.34e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	15	2.84e-02	7.44e-02	0.4100	-0.212000	0.141000	1.70e-01	0.040300	0.270000	1.56e-01	3.44e-01	2.55e-01	7.87e-01	7.00e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	9.17e-02	1.78e-01	0.4100	0.105000	0.187000	3.13e-01	-0.140000	-0.065900	5.28e-01	2.62e-01	6.01e-02	4.03e-01	6.93e-01
HDR THROUGH MMEJ ALT NHEJ	10	1.30e-01	2.30e-01	0.4100	-0.350000	0.177000	-4.82e-02	-0.107000	-0.011200	5.51e-02	3.33e-01	7.92e-01	5.59e-01	9.51e-01
OTHER SEMAPHORIN INTERACTIONS	19	2.86e-02	7.47e-02	0.4100	-0.166000	-0.112000	1.11e-01	-0.158000	0.301000	2.10e-01	3.99e-01	4.04e-01	2.35e-01	2.32e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	4.21e-01	5.32e-01	0.4090	-0.200000	-0.148000	-6.89e-02	0.217000	-0.232000	2.74e-01	4.19e-01	7.06e-01	2.35e-01	2.04e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	1.01e-01	1.92e-01	0.4080	-0.157000	-0.319000	1.68e-01	0.092400	0.056300	3.89e-01	8.06e-02	3.57e-01	6.13e-01	7.58e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	4.01e-03	1.50e-02	0.4070	-0.057000	0.071100	1.54e-01	-0.152000	0.333000	5.43e-01	4.48e-01	9.96e-02	1.05e-01	3.90e-04
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	2.94e-02	7.58e-02	0.4070	0.309000	0.179000	1.81e-01	-0.046300	-0.060100	1.04e-02	1.38e-01	1.32e-01	7.01e-01	6.18e-01
SIGNALING BY BMP	24	1.02e-01	1.94e-01	0.4060	-0.268000	-0.177000	-2.39e-01	0.053800	-0.030900	2.29e-02	1.33e-01	4.23e-02	6.48e-01	7.93e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	4.21e-03	1.56e-02	0.4050	-0.159000	-0.153000	-1.95e-02	0.260000	0.217000	2.31e-01	2.48e-01	8.83e-01	4.97e-02	1.02e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	30	2.50e-02	6.74e-02	0.4040	-0.038700	-0.179000	-1.60e-01	-0.151000	-0.286000	7.14e-01	9.06e-02	1.30e-01	1.52e-01	6.71e-03
EXTRA NUCLEAR ESTROGEN SIGNALING	65	1.60e-04	9.32e-04	0.4040	-0.187000	-0.146000	-1.32e-01	0.225000	-0.197000	9.33e-03	4.16e-02	6.67e-02	1.68e-03	5.97e-03
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	12	5.27e-01	6.24e-01	0.4030	-0.237000	-0.015600	-2.01e-01	-0.157000	-0.203000	1.56e-01	9.25e-01	2.29e-01	3.48e-01	2.23e-01
BETA CATENIN PHOSPHORYLATION CASCADE	16	4.17e-01	5.28e-01	0.4030	-0.183000	-0.210000	-1.64e-01	0.182000	-0.158000	2.05e-01	1.46e-01	2.57e-01	2.08e-01	2.75e-01
SHC1 EVENTS IN EGFR SIGNALING	10	4.72e-01	5.76e-01	0.4020	-0.295000	-0.130000	-1.14e-01	0.127000	-0.170000	1.06e-01	4.78e-01	5.32e-01	4.86e-01	3.51e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	2.94e-01	4.16e-01	0.4020	-0.182000	-0.151000	-1.71e-01	0.244000	-0.132000	2.08e-01	2.97e-01	2.38e-01	9.17e-02	3.61e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	5.96e-03	2.07e-02	0.4010	-0.218000	-0.209000	4.74e-02	0.001070	0.260000	9.16e-02	1.06e-01	7.14e-01	9.93e-01	4.41e-02
CHAPERONE MEDIATED AUTOPHAGY	19	2.78e-02	7.32e-02	0.4010	0.262000	0.221000	-4.88e-02	0.109000	-0.170000	4.83e-02	9.53e-02	7.13e-01	4.09e-01	1.98e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	15	3.62e-02	8.95e-02	0.4010	-0.026700	0.193000	-7.20e-02	0.261000	0.222000	8.58e-01	1.95e-01	6.29e-01	8.04e-02	1.36e-01
REGULATION OF RAS BY GAPS	66	8.09e-08	9.45e-07	0.4010	0.213000	0.052900	-1.46e-01	0.166000	-0.252000	2.78e-03	4.57e-01	3.99e-02	1.96e-02	4.09e-04
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	67	3.97e-08	4.88e-07	0.4000	0.150000	0.043500	-2.04e-01	0.099500	-0.291000	3.44e-02	5.38e-01	3.97e-03	1.59e-01	3.81e-05
DSCAM INTERACTIONS	10	2.79e-01	4.00e-01	0.4000	-0.270000	-0.073000	1.25e-01	-0.242000	0.084400	1.39e-01	6.89e-01	4.93e-01	1.84e-01	6.44e-01
PROTEIN LOCALIZATION	156	1.32e-15	5.67e-14	0.3990	0.153000	-0.011300	-6.00e-02	0.226000	-0.285000	9.54e-04	8.08e-01	1.96e-01	1.12e-06	8.86e-10
LATE ENDOSOMAL MICROAUTOPHAGY	30	7.94e-03	2.67e-02	0.3990	0.275000	0.162000	6.03e-02	0.167000	-0.159000	9.10e-03	1.24e-01	5.68e-01	1.13e-01	1.31e-01
DNA DAMAGE BYPASS	45	9.29e-03	3.09e-02	0.3990	-0.047900	-0.213000	-1.89e-01	-0.089600	-0.260000	5.79e-01	1.37e-02	2.82e-02	2.98e-01	2.54e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA	12	2.42e-01	3.61e-01	0.3980	0.019600	-0.185000	6.78e-02	0.333000	-0.094100	9.06e-01	2.68e-01	6.84e-01	4.60e-02	5.73e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	1.74e-01	2.84e-01	0.3980	-0.034200	-0.150000	-1.38e-01	0.152000	-0.304000	7.77e-01	2.14e-01	2.51e-01	2.08e-01	1.15e-02
DEADENYLATION OF MRNA	25	2.23e-01	3.37e-01	0.3980	-0.223000	-0.141000	-2.23e-01	0.123000	-0.154000	5.35e-02	2.21e-01	5.40e-02	2.86e-01	1.82e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	5.75e-03	2.00e-02	0.3980	-0.287000	-0.201000	8.51e-02	-0.026900	0.166000	2.28e-02	1.11e-01	5.00e-01	8.31e-01	1.88e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	2.16e-01	3.32e-01	0.3970	-0.144000	0.159000	-1.75e-01	0.136000	-0.251000	4.10e-01	3.62e-01	3.15e-01	4.35e-01	1.49e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	3.89e-01	5.03e-01	0.3970	0.219000	0.082100	2.24e-01	0.229000	0.016300	1.43e-01	5.82e-01	1.33e-01	1.25e-01	9.13e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	7.01e-01	7.65e-01	0.3970	0.162000	0.200000	2.49e-01	-0.064600	0.159000	3.10e-01	2.12e-01	1.21e-01	6.87e-01	3.22e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	23	2.69e-02	7.09e-02	0.3960	0.089400	-0.167000	9.60e-02	0.306000	-0.135000	4.58e-01	1.66e-01	4.25e-01	1.10e-02	2.64e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	10	1.94e-01	3.06e-01	0.3960	0.207000	-0.211000	2.39e-01	-0.060000	0.095300	2.58e-01	2.49e-01	1.90e-01	7.42e-01	6.02e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	1.09e-01	2.00e-01	0.3960	-0.372000	0.012600	5.22e-02	-0.120000	-0.029500	3.26e-02	9.42e-01	7.64e-01	4.92e-01	8.65e-01
PURINE CATABOLISM	16	7.73e-02	1.57e-01	0.3960	-0.014000	0.165000	-2.08e-01	0.113000	-0.270000	9.23e-01	2.53e-01	1.49e-01	4.35e-01	6.17e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	6.87e-02	1.44e-01	0.3940	0.166000	-0.025300	-7.32e-03	0.312000	-0.174000	1.59e-01	8.30e-01	9.51e-01	8.23e-03	1.41e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	11	1.12e-01	2.05e-01	0.3940	-0.044000	0.207000	1.73e-01	0.277000	-0.060500	8.00e-01	2.34e-01	3.19e-01	1.11e-01	7.28e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	1.73e-01	2.84e-01	0.3940	-0.020700	-0.145000	-1.50e-01	-0.227000	-0.245000	8.86e-01	3.15e-01	3.01e-01	1.16e-01	9.02e-02
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	84	5.15e-06	4.34e-05	0.3940	0.207000	-0.020100	1.62e-01	0.288000	0.052000	1.02e-03	7.50e-01	1.04e-02	5.22e-06	4.10e-01
CELLULAR RESPONSE TO STARVATION	145	4.79e-24	3.46e-22	0.3940	0.173000	0.241000	-9.73e-02	-0.050300	-0.234000	3.23e-04	5.49e-07	4.35e-02	2.96e-01	1.13e-06
P75NTR RECRUITS SIGNALLING COMPLEXES	12	6.44e-01	7.20e-01	0.3940	0.159000	0.303000	1.49e-01	-0.006670	0.124000	3.41e-01	6.88e-02	3.72e-01	9.68e-01	4.56e-01
IRON UPTAKE AND TRANSPORT	51	2.06e-03	8.65e-03	0.3930	0.057100	-0.111000	-1.20e-01	0.261000	-0.238000	4.81e-01	1.72e-01	1.39e-01	1.28e-03	3.24e-03
TRANSCRIPTIONAL REGULATION BY MECP2	58	1.54e-05	1.15e-04	0.3920	-0.254000	-0.119000	-1.21e-02	-0.199000	0.188000	8.07e-04	1.16e-01	8.73e-01	8.88e-03	1.33e-02
CHONDROITIN SULFATE BIOSYNTHESIS	18	6.17e-02	1.34e-01	0.3920	0.050000	-0.077000	2.33e-01	0.226000	0.200000	7.13e-01	5.72e-01	8.67e-02	9.72e-02	1.42e-01
SIGNALING BY HIPPO	20	6.99e-02	1.46e-01	0.3910	-0.232000	-0.220000	-1.79e-01	0.130000	0.039800	7.23e-02	8.81e-02	1.65e-01	3.13e-01	7.58e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	25	6.27e-02	1.35e-01	0.3900	-0.015700	-0.154000	-5.07e-02	0.329000	-0.134000	8.92e-01	1.84e-01	6.61e-01	4.46e-03	2.45e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	14	3.80e-01	4.98e-01	0.3900	-0.264000	-0.149000	-2.63e-02	-0.239000	-0.053500	8.76e-02	3.35e-01	8.65e-01	1.22e-01	7.29e-01
THE NLRP3 INFLAMMASOME	14	6.00e-02	1.32e-01	0.3890	0.133000	-0.173000	-9.21e-02	-0.219000	-0.217000	3.91e-01	2.61e-01	5.51e-01	1.55e-01	1.59e-01
PEROXISOMAL PROTEIN IMPORT	57	5.22e-04	2.63e-03	0.3890	0.077100	-0.100000	-6.94e-02	0.293000	-0.212000	3.14e-01	1.91e-01	3.65e-01	1.32e-04	5.64e-03
RRNA PROCESSING	194	1.08e-32	1.56e-30	0.3890	0.207000	0.230000	-9.82e-02	-0.086400	-0.196000	6.78e-07	3.27e-08	1.85e-02	3.83e-02	2.74e-06
MITOCHONDRIAL TRNA AMINOACYLATION	21	2.33e-01	3.49e-01	0.3890	0.272000	0.018200	1.73e-01	0.188000	0.108000	3.13e-02	8.85e-01	1.70e-01	1.36e-01	3.90e-01
HEDGEHOG OFF STATE	106	4.07e-07	4.28e-06	0.3880	0.274000	0.134000	4.72e-02	0.236000	0.000859	1.16e-06	1.71e-02	4.01e-01	2.71e-05	9.88e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	24	7.89e-03	2.66e-02	0.3880	-0.033700	-0.078200	1.90e-01	0.117000	0.305000	7.75e-01	5.08e-01	1.07e-01	3.21e-01	9.63e-03
GLUTATHIONE CONJUGATION	29	1.96e-03	8.30e-03	0.3870	0.104000	0.060000	-1.80e-02	0.131000	-0.343000	3.30e-01	5.76e-01	8.67e-01	2.22e-01	1.38e-03
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	3.68e-01	4.88e-01	0.3870	0.104000	-0.175000	-1.37e-01	0.241000	-0.178000	5.15e-01	2.75e-01	3.94e-01	1.33e-01	2.67e-01
ANTIGEN PROCESSING CROSS PRESENTATION	93	1.22e-12	3.06e-11	0.3860	0.170000	0.087700	-2.03e-01	0.051600	-0.262000	4.64e-03	1.44e-01	7.16e-04	3.90e-01	1.29e-05
ABC TRANSPORTER DISORDERS	68	6.15e-07	6.03e-06	0.3860	0.217000	0.095500	-1.14e-01	0.206000	-0.192000	1.95e-03	1.73e-01	1.04e-01	3.35e-03	6.15e-03
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	5.31e-01	6.28e-01	0.3850	0.223000	0.150000	2.05e-01	-0.079700	0.167000	1.02e-01	2.72e-01	1.32e-01	5.58e-01	2.19e-01
PEROXISOMAL LIPID METABOLISM	26	8.06e-02	1.61e-01	0.3850	0.069200	-0.043100	-1.13e-01	0.311000	-0.180000	5.42e-01	7.03e-01	3.18e-01	6.13e-03	1.12e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	1.79e-01	2.90e-01	0.3850	-0.116000	-0.270000	7.22e-02	0.211000	-0.108000	4.87e-01	1.05e-01	6.65e-01	2.05e-01	5.19e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	11	4.16e-01	5.28e-01	0.3840	-0.021500	0.065600	-2.29e-01	0.140000	-0.266000	9.02e-01	7.06e-01	1.88e-01	4.22e-01	1.26e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	7.22e-02	1.49e-01	0.3840	0.037700	-0.214000	1.17e-01	0.256000	0.146000	8.01e-01	1.52e-01	4.31e-01	8.64e-02	3.29e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	1.42e-02	4.31e-02	0.3830	0.173000	-0.053300	-1.57e-01	0.068900	-0.291000	1.42e-01	6.52e-01	1.84e-01	5.59e-01	1.35e-02
INTERLEUKIN 12 FAMILY SIGNALING	42	3.97e-03	1.49e-02	0.3830	0.002950	0.025700	-2.06e-01	0.164000	-0.277000	9.74e-01	7.73e-01	2.08e-02	6.60e-02	1.90e-03
LONG TERM POTENTIATION	23	1.51e-03	6.53e-03	0.3820	-0.276000	-0.170000	1.37e-01	0.034600	0.143000	2.18e-02	1.58e-01	2.56e-01	7.74e-01	2.34e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	2.50e-02	6.74e-02	0.3820	0.137000	0.182000	-9.27e-02	0.165000	-0.241000	2.65e-01	1.40e-01	4.52e-01	1.81e-01	5.06e-02
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	6.80e-01	7.48e-01	0.3810	0.052000	0.236000	2.18e-01	0.024400	0.198000	7.65e-01	1.76e-01	2.11e-01	8.89e-01	2.55e-01
MITOPHAGY	29	9.94e-03	3.22e-02	0.3800	0.104000	0.142000	-5.52e-02	0.226000	-0.244000	3.32e-01	1.85e-01	6.07e-01	3.56e-02	2.31e-02
REGULATION OF BACH1 ACTIVITY	11	5.54e-01	6.47e-01	0.3790	0.005920	-0.048400	-2.12e-01	0.099400	-0.294000	9.73e-01	7.81e-01	2.24e-01	5.68e-01	9.09e-02
ADHERENS JUNCTIONS INTERACTIONS	29	1.83e-02	5.28e-02	0.3790	-0.234000	-0.252000	-1.35e-01	0.070100	0.050500	2.93e-02	1.90e-02	2.08e-01	5.14e-01	6.38e-01
PI 3K CASCADE FGFR1	14	2.64e-01	3.85e-01	0.3780	-0.171000	0.069700	-1.42e-01	-0.215000	-0.206000	2.67e-01	6.52e-01	3.59e-01	1.64e-01	1.82e-01
PHASE II CONJUGATION OF COMPOUNDS	60	2.16e-05	1.54e-04	0.3780	0.037200	0.004880	-9.98e-02	0.130000	-0.338000	6.19e-01	9.48e-01	1.81e-01	8.08e-02	5.89e-06
ERKS ARE INACTIVATED	13	1.13e-01	2.06e-01	0.3780	-0.053100	-0.134000	1.04e-01	0.236000	-0.235000	7.40e-01	4.02e-01	5.17e-01	1.40e-01	1.43e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	18	7.55e-03	2.55e-02	0.3770	-0.294000	0.116000	-5.46e-02	0.158000	0.119000	3.07e-02	3.93e-01	6.89e-01	2.45e-01	3.81e-01
NUCLEAR ENVELOPE NE REASSEMBLY	63	1.33e-04	7.98e-04	0.3770	0.145000	0.068200	3.53e-02	0.306000	-0.147000	4.69e-02	3.50e-01	6.28e-01	2.69e-05	4.31e-02
HIV TRANSCRIPTION INITIATION	45	6.23e-04	3.05e-03	0.3760	0.006350	-0.025100	-1.68e-01	-0.059000	-0.331000	9.41e-01	7.71e-01	5.13e-02	4.94e-01	1.24e-04
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	3.15e-01	4.37e-01	0.3760	-0.160000	-0.142000	-1.60e-01	0.211000	-0.161000	2.16e-01	2.72e-01	2.16e-01	1.03e-01	2.13e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	5.85e-02	1.30e-01	0.3750	0.002290	0.237000	6.53e-02	0.181000	0.219000	9.85e-01	5.45e-02	5.96e-01	1.43e-01	7.56e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	6.03e-02	1.32e-01	0.3740	0.121000	0.066200	1.37e-02	-0.334000	-0.094900	4.01e-01	6.47e-01	9.24e-01	2.07e-02	5.11e-01
CDC42 GTPASE CYCLE	151	1.12e-11	2.35e-10	0.3740	-0.056900	0.156000	2.26e-01	-0.043300	0.243000	2.28e-01	9.34e-04	1.64e-06	3.59e-01	2.57e-07
GOLGI TO ER RETROGRADE TRANSPORT	117	5.56e-08	6.69e-07	0.3740	0.164000	-0.016200	8.63e-02	0.324000	0.001930	2.23e-03	7.63e-01	1.07e-01	1.39e-09	9.71e-01
CELL CELL JUNCTION ORGANIZATION	47	3.74e-03	1.42e-02	0.3740	-0.221000	-0.275000	-8.10e-02	0.074900	-0.056100	8.80e-03	1.12e-03	3.37e-01	3.74e-01	5.06e-01
CD28 CO STIMULATION	30	1.16e-01	2.11e-01	0.3730	-0.072200	-0.228000	-1.41e-01	0.204000	-0.145000	4.94e-01	3.07e-02	1.83e-01	5.37e-02	1.69e-01
INFLUENZA INFECTION	145	2.73e-22	1.66e-20	0.3730	0.120000	0.209000	-1.28e-01	-0.148000	-0.207000	1.24e-02	1.41e-05	8.12e-03	2.14e-03	1.77e-05
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	4.22e-03	1.56e-02	0.3730	0.128000	0.004530	1.99e-01	0.203000	0.204000	1.26e-01	9.57e-01	1.69e-02	1.51e-02	1.44e-02
MITOTIC G1 PHASE AND G1 S TRANSITION	140	3.17e-10	5.40e-09	0.3720	0.067700	-0.056200	-1.55e-01	0.153000	-0.289000	1.67e-01	2.52e-01	1.52e-03	1.83e-03	3.84e-09
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	1.04e-01	1.95e-01	0.3720	0.167000	-0.081600	2.32e-02	0.102000	-0.304000	2.62e-01	5.84e-01	8.77e-01	4.94e-01	4.12e-02
COPII MEDIATED VESICLE TRANSPORT	64	8.36e-06	6.67e-05	0.3720	0.020300	-0.190000	4.80e-02	0.238000	-0.206000	7.79e-01	8.47e-03	5.07e-01	9.79e-04	4.37e-03
RHOBTB2 GTPASE CYCLE	23	2.96e-02	7.59e-02	0.3720	-0.060500	0.149000	-2.08e-01	0.220000	-0.143000	6.16e-01	2.17e-01	8.37e-02	6.77e-02	2.35e-01
COLLAGEN DEGRADATION	49	7.04e-03	2.39e-02	0.3710	0.068900	0.300000	1.73e-01	-0.050500	0.105000	4.04e-01	2.88e-04	3.62e-02	5.41e-01	2.04e-01
DISEASES OF DNA REPAIR	11	2.32e-01	3.49e-01	0.3700	0.145000	0.248000	-1.14e-01	0.169000	0.113000	4.06e-01	1.54e-01	5.11e-01	3.31e-01	5.16e-01
RNA POLYMERASE III CHAIN ELONGATION	18	1.85e-02	5.29e-02	0.3700	0.225000	0.097600	-3.04e-02	-0.054700	-0.269000	9.78e-02	4.73e-01	8.23e-01	6.88e-01	4.79e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	4.39e-23	2.82e-21	0.3690	0.105000	0.132000	-1.07e-01	-0.009080	-0.311000	1.82e-02	2.79e-03	1.58e-02	8.37e-01	2.22e-12
METABOLISM OF AMINO ACIDS AND DERIVATIVES	304	4.22e-35	1.08e-32	0.3690	0.193000	0.183000	-8.82e-02	0.128000	-0.203000	7.54e-09	4.47e-08	8.37e-03	1.35e-04	1.26e-09
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	2.10e-01	3.25e-01	0.3690	-0.133000	-0.320000	-4.70e-03	-0.009730	-0.126000	3.43e-01	2.25e-02	9.73e-01	9.45e-01	3.68e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	6.18e-02	1.34e-01	0.3680	0.281000	0.005690	-5.10e-02	0.023500	-0.231000	5.98e-02	9.70e-01	7.32e-01	8.75e-01	1.22e-01
ER QUALITY CONTROL COMPARTMENT ERQC	21	1.05e-01	1.96e-01	0.3680	0.003910	-0.047200	-1.55e-01	0.326000	-0.050800	9.75e-01	7.08e-01	2.19e-01	9.71e-03	6.87e-01
PKMTS METHYLATE HISTONE LYSINES	47	5.33e-03	1.90e-02	0.3680	-0.072900	0.012000	1.04e-01	-0.295000	0.179000	3.87e-01	8.87e-01	2.17e-01	4.76e-04	3.40e-02
RA BIOSYNTHESIS PATHWAY	10	3.01e-01	4.24e-01	0.3670	0.287000	-0.018600	-3.44e-02	0.104000	-0.199000	1.16e-01	9.19e-01	8.51e-01	5.71e-01	2.75e-01
ANTIMICROBIAL PEPTIDES	12	4.26e-01	5.37e-01	0.3660	0.296000	0.177000	5.64e-02	0.091100	-0.056600	7.58e-02	2.87e-01	7.35e-01	5.85e-01	7.34e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	1.37e-01	2.38e-01	0.3650	-0.215000	-0.113000	1.17e-01	0.075600	0.235000	2.17e-01	5.17e-01	5.03e-01	6.64e-01	1.77e-01
TNFR2 NON CANONICAL NF KB PATHWAY	78	1.04e-08	1.42e-07	0.3650	0.228000	0.113000	-6.13e-02	0.093200	-0.237000	5.05e-04	8.52e-02	3.50e-01	1.55e-01	3.04e-04
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	4.93e-02	1.13e-01	0.3650	-0.252000	-0.237000	2.20e-04	0.115000	0.002940	5.14e-02	6.62e-02	9.99e-01	3.72e-01	9.82e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	83	5.44e-10	8.99e-09	0.3640	0.175000	0.051000	-1.50e-01	0.022200	-0.276000	5.82e-03	4.22e-01	1.80e-02	7.27e-01	1.36e-05
PCP CE PATHWAY	89	2.54e-08	3.23e-07	0.3640	0.275000	0.086200	-5.42e-03	0.147000	-0.167000	7.52e-06	1.60e-01	9.30e-01	1.63e-02	6.40e-03
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	3.32e-03	1.29e-02	0.3640	0.156000	0.043300	-1.99e-02	0.140000	-0.294000	1.20e-01	6.67e-01	8.43e-01	1.65e-01	3.50e-03
CARGO CONCENTRATION IN THE ER	30	2.06e-02	5.79e-02	0.3640	-0.020600	-0.149000	2.53e-02	0.268000	-0.193000	8.45e-01	1.57e-01	8.10e-01	1.10e-02	6.75e-02
TIE2 SIGNALING	17	2.30e-01	3.46e-01	0.3640	-0.249000	0.012000	-2.25e-01	0.098700	-0.098900	7.53e-02	9.32e-01	1.08e-01	4.81e-01	4.80e-01
PEPTIDE HORMONE METABOLISM	57	2.03e-03	8.56e-03	0.3630	-0.080900	-0.131000	-2.62e-01	0.168000	-0.106000	2.91e-01	8.64e-02	6.28e-04	2.86e-02	1.65e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	7.18e-08	8.56e-07	0.3630	0.168000	0.050800	-1.08e-01	0.134000	-0.267000	8.63e-03	4.26e-01	9.05e-02	3.58e-02	2.93e-05
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	3.62e-01	4.83e-01	0.3620	-0.096700	-0.047000	-3.31e-02	-0.344000	-0.009540	5.17e-01	7.53e-01	8.25e-01	2.09e-02	9.49e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	3.06e-01	4.29e-01	0.3620	0.115000	0.096800	3.67e-03	0.204000	-0.259000	4.89e-01	5.61e-01	9.82e-01	2.22e-01	1.21e-01
UNFOLDED PROTEIN RESPONSE UPR	84	5.04e-04	2.58e-03	0.3620	0.251000	0.128000	1.04e-01	0.202000	0.008140	7.27e-05	4.28e-02	9.95e-02	1.38e-03	8.97e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	25	2.35e-03	9.57e-03	0.3620	0.101000	0.110000	-3.22e-02	-0.156000	-0.288000	3.82e-01	3.41e-01	7.80e-01	1.76e-01	1.26e-02
METAL ION SLC TRANSPORTERS	24	1.44e-02	4.37e-02	0.3610	-0.286000	-0.125000	-9.43e-02	0.128000	0.088100	1.53e-02	2.88e-01	4.24e-01	2.78e-01	4.55e-01
INTERLEUKIN 7 SIGNALING	19	1.17e-01	2.12e-01	0.3610	0.141000	-0.063000	1.28e-01	-0.128000	0.272000	2.89e-01	6.34e-01	3.36e-01	3.35e-01	4.04e-02
COMPLEMENT CASCADE	22	3.95e-02	9.40e-02	0.3610	0.034700	0.338000	-4.67e-02	-0.036600	0.106000	7.78e-01	6.10e-03	7.05e-01	7.66e-01	3.90e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	31	1.25e-01	2.22e-01	0.3600	0.070000	0.290000	1.47e-01	-0.034700	0.133000	5.00e-01	5.13e-03	1.56e-01	7.38e-01	2.00e-01
RHOB GTPASE CYCLE	66	6.14e-05	3.99e-04	0.3590	-0.075700	0.137000	1.80e-01	-0.015500	0.269000	2.88e-01	5.50e-02	1.16e-02	8.27e-01	1.61e-04
PI 3K CASCADE FGFR3	12	2.72e-01	3.92e-01	0.3590	-0.208000	0.182000	-1.73e-01	-0.149000	-0.023500	2.13e-01	2.76e-01	2.99e-01	3.72e-01	8.88e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	19	1.48e-01	2.53e-01	0.3590	0.088300	-0.236000	-1.73e-02	0.237000	-0.093600	5.05e-01	7.55e-02	8.96e-01	7.32e-02	4.80e-01
HYALURONAN METABOLISM	15	3.08e-01	4.30e-01	0.3590	0.096100	-0.036300	1.85e-01	0.119000	0.264000	5.20e-01	8.08e-01	2.14e-01	4.24e-01	7.70e-02
TELOMERE C STRAND SYNTHESIS INITIATION	13	3.48e-01	4.70e-01	0.3580	0.099800	0.100000	-8.37e-02	0.219000	-0.231000	5.33e-01	5.32e-01	6.01e-01	1.71e-01	1.49e-01
SIGNALING BY HEDGEHOG	141	4.30e-07	4.48e-06	0.3580	0.219000	0.122000	6.65e-02	0.242000	0.046200	7.07e-06	1.23e-02	1.73e-01	7.23e-07	3.44e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	139	5.98e-11	1.15e-09	0.3580	0.134000	-0.051300	1.22e-01	0.285000	-0.107000	6.41e-03	2.97e-01	1.34e-02	6.59e-09	3.01e-02
RAF ACTIVATION	34	2.96e-02	7.59e-02	0.3580	-0.018000	-0.114000	-2.37e-02	0.286000	-0.180000	8.56e-01	2.51e-01	8.11e-01	3.94e-03	6.90e-02
SHC MEDIATED CASCADE FGFR4	10	4.08e-01	5.20e-01	0.3580	-0.081300	0.078000	-3.10e-01	0.066300	-0.122000	6.56e-01	6.69e-01	8.99e-02	7.16e-01	5.05e-01
CA DEPENDENT EVENTS	36	8.21e-05	5.16e-04	0.3570	-0.255000	-0.143000	4.35e-02	0.169000	0.109000	8.13e-03	1.39e-01	6.51e-01	7.99e-02	2.56e-01
NEUREXINS AND NEUROLIGINS	54	1.05e-05	8.31e-05	0.3570	-0.155000	0.033600	1.68e-01	-0.000836	0.272000	4.89e-02	6.69e-01	3.24e-02	9.92e-01	5.44e-04
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	167	9.64e-14	3.38e-12	0.3570	0.112000	-0.080600	1.09e-01	0.289000	-0.115000	1.26e-02	7.27e-02	1.57e-02	1.28e-10	1.01e-02
TRANSLESION SYNTHESIS BY POLK	17	2.49e-01	3.70e-01	0.3570	-0.052200	-0.017700	-1.78e-01	-0.153000	-0.262000	7.09e-01	8.99e-01	2.03e-01	2.73e-01	6.14e-02
G PROTEIN BETA GAMMA SIGNALLING	30	2.93e-01	4.16e-01	0.3560	-0.146000	-0.178000	-1.35e-01	0.090600	-0.217000	1.67e-01	9.08e-02	2.01e-01	3.90e-01	3.99e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	49	2.34e-03	9.57e-03	0.3560	-0.013500	0.062100	1.75e-01	-0.291000	0.083700	8.70e-01	4.52e-01	3.39e-02	4.23e-04	3.11e-01
AUTOPHAGY	137	7.16e-09	9.97e-08	0.3560	0.186000	0.089600	6.09e-02	0.257000	-0.118000	1.76e-04	7.05e-02	2.19e-01	2.01e-07	1.69e-02
PREGNENOLONE BIOSYNTHESIS	12	3.60e-01	4.82e-01	0.3550	0.306000	0.147000	8.82e-02	-0.050900	-0.029200	6.69e-02	3.77e-01	5.97e-01	7.60e-01	8.61e-01
SPRY REGULATION OF FGF SIGNALING	16	3.21e-01	4.42e-01	0.3550	0.136000	-0.031700	1.24e-01	0.298000	-0.047100	3.48e-01	8.26e-01	3.89e-01	3.90e-02	7.45e-01
ERBB2 ACTIVATES PTK6 SIGNALING	10	2.99e-01	4.21e-01	0.3540	-0.318000	-0.071400	6.06e-02	-0.081100	0.097000	8.21e-02	6.96e-01	7.40e-01	6.57e-01	5.95e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	3.03e-01	4.25e-01	0.3540	-0.156000	-0.024400	-5.79e-02	0.265000	-0.164000	3.29e-01	8.79e-01	7.18e-01	9.81e-02	3.06e-01
INTERLEUKIN 10 SIGNALING	16	6.51e-01	7.27e-01	0.3540	-0.204000	-0.088400	-1.72e-01	-0.183000	-0.112000	1.58e-01	5.40e-01	2.33e-01	2.05e-01	4.38e-01
HYALURONAN UPTAKE AND DEGRADATION	11	5.27e-01	6.24e-01	0.3530	0.142000	-0.046400	4.48e-02	0.309000	0.069300	4.14e-01	7.90e-01	7.97e-01	7.57e-02	6.91e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	3.46e-02	8.66e-02	0.3530	-0.029700	-0.168000	-1.51e-01	-0.147000	-0.226000	7.55e-01	7.79e-02	1.11e-01	1.22e-01	1.76e-02
SIGNALING BY ERBB2 ECD MUTANTS	16	5.65e-01	6.57e-01	0.3520	-0.272000	-0.081100	-1.86e-01	-0.061900	-0.072800	5.97e-02	5.75e-01	1.98e-01	6.68e-01	6.14e-01
NGF STIMULATED TRANSCRIPTION	36	3.01e-04	1.66e-03	0.3520	-0.037400	-0.127000	7.42e-02	0.068100	-0.310000	6.98e-01	1.86e-01	4.41e-01	4.80e-01	1.30e-03
GRB2 EVENTS IN ERBB2 SIGNALING	14	7.25e-01	7.85e-01	0.3510	-0.241000	-0.184000	-1.49e-01	-0.009930	-0.095600	1.18e-01	2.34e-01	3.36e-01	9.49e-01	5.36e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	3.56e-01	4.79e-01	0.3510	0.108000	-0.076500	2.62e-01	-0.021900	0.191000	4.85e-01	6.20e-01	8.98e-02	8.87e-01	2.17e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	6.04e-02	1.32e-01	0.3500	-0.152000	0.073500	1.93e-01	0.039700	0.236000	2.63e-01	5.89e-01	1.57e-01	7.71e-01	8.36e-02
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	3.44e-01	4.65e-01	0.3500	-0.040800	0.281000	1.21e-01	0.020200	0.164000	7.91e-01	6.90e-02	4.32e-01	8.96e-01	2.88e-01
RAS PROCESSING	24	3.76e-02	9.14e-02	0.3500	0.083800	0.054900	-7.00e-02	0.107000	-0.309000	4.77e-01	6.42e-01	5.53e-01	3.63e-01	8.69e-03
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	16	4.31e-01	5.42e-01	0.3490	0.059900	-0.059900	-8.59e-02	0.266000	-0.191000	6.78e-01	6.79e-01	5.52e-01	6.54e-02	1.86e-01
DAG AND IP3 SIGNALING	40	1.94e-05	1.40e-04	0.3490	-0.242000	-0.079300	7.74e-02	0.118000	0.193000	8.18e-03	3.86e-01	3.97e-01	1.97e-01	3.49e-02
ENOS ACTIVATION	11	6.75e-01	7.45e-01	0.3480	-0.168000	-0.074000	-1.23e-01	0.130000	-0.236000	3.35e-01	6.71e-01	4.79e-01	4.54e-01	1.76e-01
ZINC TRANSPORTERS	15	2.03e-01	3.17e-01	0.3480	-0.313000	-0.091800	-9.92e-02	0.063800	0.034400	3.60e-02	5.38e-01	5.06e-01	6.69e-01	8.18e-01
PLASMA LIPOPROTEIN CLEARANCE	26	2.93e-01	4.16e-01	0.3480	0.210000	0.051800	1.43e-01	0.217000	0.080800	6.34e-02	6.48e-01	2.06e-01	5.57e-02	4.76e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	3.57e-02	8.91e-02	0.3470	-0.123000	-0.064700	-4.37e-02	0.312000	-0.047200	2.77e-01	5.68e-01	7.00e-01	5.96e-03	6.77e-01
SYNTHESIS OF PA	29	1.72e-01	2.83e-01	0.3460	0.127000	0.051700	1.66e-01	0.194000	0.188000	2.35e-01	6.30e-01	1.21e-01	7.05e-02	7.97e-02
RESOLUTION OF D LOOP STRUCTURES	30	1.58e-01	2.67e-01	0.3460	-0.149000	-0.109000	-8.33e-02	-0.278000	-0.034700	1.57e-01	3.03e-01	4.30e-01	8.41e-03	7.43e-01
POLYMERASE SWITCHING	14	1.01e-01	1.93e-01	0.3450	0.190000	0.084200	-6.56e-02	-0.064800	-0.259000	2.18e-01	5.86e-01	6.71e-01	6.75e-01	9.30e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	2.63e-01	3.85e-01	0.3450	0.105000	0.123000	2.26e-01	0.087400	0.184000	3.05e-01	2.28e-01	2.67e-02	3.93e-01	7.24e-02
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	20	1.48e-01	2.53e-01	0.3450	-0.103000	0.091100	-1.96e-01	-0.050400	-0.242000	4.24e-01	4.81e-01	1.29e-01	6.96e-01	6.06e-02
RHOBTB1 GTPASE CYCLE	23	4.06e-02	9.58e-02	0.3440	-0.148000	0.096200	-2.77e-01	0.084300	-0.057400	2.20e-01	4.25e-01	2.14e-02	4.84e-01	6.33e-01
RHOC GTPASE CYCLE	72	8.02e-05	5.07e-04	0.3440	-0.047600	0.159000	1.31e-01	0.022400	0.271000	4.85e-01	1.99e-02	5.51e-02	7.42e-01	7.22e-05
GP1B IX V ACTIVATION SIGNALLING	10	7.45e-01	8.01e-01	0.3430	-0.025400	0.124000	1.76e-01	-0.100000	0.246000	8.90e-01	4.96e-01	3.34e-01	5.84e-01	1.79e-01
INTERLEUKIN 15 SIGNALING	12	2.79e-01	4.00e-01	0.3410	-0.020600	-0.119000	5.53e-03	-0.180000	0.264000	9.02e-01	4.74e-01	9.74e-01	2.82e-01	1.13e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	5.98e-02	1.32e-01	0.3410	0.174000	-0.046100	-1.26e-01	0.047100	-0.257000	1.68e-01	7.15e-01	3.17e-01	7.09e-01	4.16e-02
NUCLEOTIDE SALVAGE	21	1.60e-01	2.69e-01	0.3410	0.223000	-0.092900	4.92e-02	0.236000	-0.007770	7.73e-02	4.61e-01	6.97e-01	6.17e-02	9.51e-01
PROTEIN FOLDING	88	2.75e-05	1.88e-04	0.3400	0.178000	0.098000	9.01e-03	0.241000	-0.128000	3.94e-03	1.12e-01	8.84e-01	9.20e-05	3.84e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	32	3.76e-01	4.96e-01	0.3400	-0.088100	-0.181000	-1.91e-01	0.045500	-0.191000	3.89e-01	7.64e-02	6.21e-02	6.56e-01	6.12e-02
FORMATION OF INCISION COMPLEX IN GG NER	43	8.76e-02	1.72e-01	0.3400	-0.108000	-0.069600	-1.62e-01	0.097700	-0.252000	2.22e-01	4.30e-01	6.68e-02	2.68e-01	4.31e-03
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	5.69e-01	6.60e-01	0.3400	-0.042100	-0.103000	-2.11e-01	0.100000	-0.220000	7.57e-01	4.48e-01	1.22e-01	4.62e-01	1.06e-01
PYROPTOSIS	20	3.46e-01	4.68e-01	0.3390	-0.028500	-0.051800	-1.89e-01	0.016000	-0.275000	8.25e-01	6.89e-01	1.43e-01	9.02e-01	3.33e-02
DCC MEDIATED ATTRACTIVE SIGNALING	14	1.43e-01	2.46e-01	0.3390	-0.295000	-0.110000	4.81e-02	-0.010700	0.117000	5.63e-02	4.77e-01	7.55e-01	9.45e-01	4.48e-01
FCERI MEDIATED MAPK ACTIVATION	28	7.81e-02	1.58e-01	0.3390	-0.214000	-0.033900	-1.14e-01	0.149000	-0.181000	5.02e-02	7.56e-01	2.96e-01	1.73e-01	9.70e-02
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	7.97e-01	8.41e-01	0.3390	-0.081400	-0.133000	-2.43e-01	0.089200	-0.153000	6.40e-01	4.43e-01	1.63e-01	6.08e-01	3.79e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	6.22e-02	1.35e-01	0.3380	-0.266000	0.010000	-8.23e-02	0.188000	-0.042200	4.50e-02	9.40e-01	5.35e-01	1.57e-01	7.50e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	3.77e-01	4.97e-01	0.3380	-0.261000	-0.148000	-1.37e-01	-0.007330	0.075700	9.11e-02	3.37e-01	3.76e-01	9.62e-01	6.24e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	4.69e-01	5.75e-01	0.3380	0.179000	0.272000	5.31e-02	0.043600	-0.059300	2.83e-01	1.03e-01	7.50e-01	7.94e-01	7.22e-01
REGULATION OF IFNA SIGNALING	12	1.60e-01	2.69e-01	0.3380	0.183000	-0.199000	5.80e-02	-0.148000	0.125000	2.73e-01	2.33e-01	7.28e-01	3.73e-01	4.53e-01
CTLA4 INHIBITORY SIGNALING	20	3.18e-01	4.39e-01	0.3380	0.028100	-0.087900	-5.15e-02	0.284000	-0.148000	8.28e-01	4.96e-01	6.90e-01	2.77e-02	2.53e-01
RHO GTPASES ACTIVATE ROCKS	19	2.16e-01	3.32e-01	0.3370	0.023800	0.312000	4.23e-02	-0.072700	0.093800	8.58e-01	1.86e-02	7.50e-01	5.84e-01	4.79e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	80	8.81e-08	9.99e-07	0.3360	0.169000	0.017200	-8.37e-02	0.038300	-0.275000	8.90e-03	7.91e-01	1.96e-01	5.54e-01	2.21e-05
SIGNALING BY FLT3 ITD AND TKD MUTANTS	15	1.86e-01	2.98e-01	0.3350	-0.107000	-0.196000	-1.90e-01	-0.113000	0.117000	4.74e-01	1.89e-01	2.02e-01	4.49e-01	4.32e-01
G PROTEIN MEDIATED EVENTS	51	1.79e-06	1.61e-05	0.3350	-0.253000	-0.059800	3.39e-02	0.132000	0.163000	1.80e-03	4.60e-01	6.75e-01	1.03e-01	4.44e-02
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	5.40e-01	6.35e-01	0.3350	-0.120000	-0.018500	-2.79e-02	-0.280000	0.135000	4.53e-01	9.08e-01	8.62e-01	8.01e-02	4.01e-01
HDACS DEACETYLATE HISTONES	44	1.13e-02	3.58e-02	0.3350	0.011700	0.142000	1.99e-01	-0.217000	0.071700	8.93e-01	1.03e-01	2.25e-02	1.27e-02	4.11e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	8.31e-01	8.70e-01	0.3350	0.210000	0.097500	1.55e-01	0.036500	0.182000	2.08e-01	5.59e-01	3.52e-01	8.27e-01	2.75e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	24	2.26e-01	3.41e-01	0.3350	-0.042400	-0.224000	-1.96e-01	0.119000	-0.086200	7.19e-01	5.76e-02	9.69e-02	3.11e-01	4.65e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	5.61e-03	1.97e-02	0.3340	-0.217000	-0.124000	3.19e-02	0.220000	0.003150	4.71e-02	2.56e-01	7.70e-01	4.41e-02	9.77e-01
EPHRIN SIGNALING	19	2.65e-01	3.86e-01	0.3340	0.134000	-0.085000	9.69e-02	0.277000	0.017100	3.11e-01	5.21e-01	4.65e-01	3.67e-02	8.97e-01
SIGNAL AMPLIFICATION	29	1.30e-01	2.30e-01	0.3330	-0.014900	-0.044700	-9.97e-02	0.289000	-0.123000	8.90e-01	6.77e-01	3.53e-01	7.00e-03	2.52e-01
EFFECTS OF PIP2 HYDROLYSIS	27	2.55e-02	6.83e-02	0.3330	-0.169000	0.032600	1.62e-01	-0.078200	0.221000	1.28e-01	7.69e-01	1.45e-01	4.82e-01	4.70e-02
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	1.85e-01	2.96e-01	0.3330	0.040000	-0.216000	7.77e-02	0.192000	-0.141000	7.75e-01	1.24e-01	5.79e-01	1.71e-01	3.14e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	2.59e-06	2.26e-05	0.3330	-0.079000	-0.134000	7.24e-02	0.052400	-0.280000	2.98e-01	7.70e-02	3.40e-01	4.90e-01	2.28e-04
MHC CLASS II ANTIGEN PRESENTATION	100	2.36e-05	1.67e-04	0.3320	0.130000	0.006140	6.23e-02	0.292000	-0.066400	2.44e-02	9.16e-01	2.82e-01	4.73e-07	2.52e-01
GAB1 SIGNALOSOME	13	1.40e-01	2.42e-01	0.3320	-0.245000	0.080700	1.58e-01	-0.115000	0.074200	1.26e-01	6.14e-01	3.23e-01	4.73e-01	6.43e-01
DAP12 INTERACTIONS	29	4.13e-01	5.25e-01	0.3320	-0.192000	-0.119000	-1.31e-01	-0.149000	-0.141000	7.40e-02	2.66e-01	2.21e-01	1.65e-01	1.90e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS	18	3.92e-02	9.39e-02	0.3320	0.170000	-0.044300	9.55e-03	-0.185000	-0.211000	2.11e-01	7.45e-01	9.44e-01	1.73e-01	1.21e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	54	6.93e-02	1.45e-01	0.3310	-0.121000	-0.187000	-1.33e-01	0.135000	-0.154000	1.23e-01	1.77e-02	8.99e-02	8.61e-02	4.97e-02
CLEC7A DECTIN 1 SIGNALING	94	6.88e-07	6.64e-06	0.3310	0.116000	0.028400	-1.38e-01	0.122000	-0.247000	5.12e-02	6.34e-01	2.11e-02	4.12e-02	3.49e-05
CARNITINE METABOLISM	14	1.97e-01	3.10e-01	0.3300	0.172000	-0.116000	2.53e-01	-0.046000	0.001700	2.65e-01	4.51e-01	1.02e-01	7.66e-01	9.91e-01
DISEASES OF GLYCOSYLATION	121	1.11e-04	6.87e-04	0.3300	0.162000	0.031900	2.13e-01	0.118000	0.151000	2.17e-03	5.45e-01	5.16e-05	2.53e-02	4.28e-03
METABOLISM OF COFACTORS	18	1.90e-01	3.02e-01	0.3300	0.104000	0.043300	-1.22e-01	0.094900	-0.269000	4.44e-01	7.51e-01	3.71e-01	4.86e-01	4.83e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	1.57e-01	2.67e-01	0.3290	0.092200	0.136000	2.51e-01	0.130000	-0.041900	4.98e-01	3.18e-01	6.56e-02	3.40e-01	7.59e-01
SHC1 EVENTS IN ERBB2 SIGNALING	20	1.45e-01	2.49e-01	0.3290	-0.300000	-0.091800	-7.76e-02	0.060500	-0.017100	2.03e-02	4.78e-01	5.48e-01	6.40e-01	8.95e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	39	3.36e-01	4.58e-01	0.3280	0.169000	0.126000	1.86e-01	-0.047000	0.162000	6.87e-02	1.74e-01	4.40e-02	6.12e-01	7.97e-02
ASPARAGINE N LINKED GLYCOSYLATION	281	3.12e-18	1.50e-16	0.3280	0.104000	-0.084900	5.34e-02	0.263000	-0.132000	2.69e-03	1.46e-02	1.24e-01	3.87e-14	1.42e-04
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	11	2.19e-01	3.35e-01	0.3280	-0.137000	0.244000	1.56e-01	0.047000	0.051200	4.31e-01	1.62e-01	3.70e-01	7.87e-01	7.69e-01
MISMATCH REPAIR	14	1.66e-01	2.75e-01	0.3270	0.223000	0.016500	-1.20e-01	0.026700	-0.206000	1.49e-01	9.15e-01	4.38e-01	8.63e-01	1.83e-01
O LINKED GLYCOSYLATION OF MUCINS	38	9.35e-03	3.09e-02	0.3270	0.084900	-0.162000	1.07e-01	0.244000	-0.048100	3.66e-01	8.38e-02	2.55e-01	9.14e-03	6.08e-01
DISEASES OF MITOTIC CELL CYCLE	37	9.28e-02	1.79e-01	0.3270	-0.010800	-0.231000	-9.96e-02	0.029900	-0.207000	9.09e-01	1.51e-02	2.95e-01	7.53e-01	2.97e-02
METABOLISM OF FAT SOLUBLE VITAMINS	30	1.34e-01	2.35e-01	0.3260	0.250000	-0.011800	1.26e-01	0.129000	0.107000	1.78e-02	9.11e-01	2.33e-01	2.23e-01	3.10e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	3.12e-01	4.34e-01	0.3260	0.205000	0.053600	1.44e-01	0.089400	0.182000	5.60e-02	6.18e-01	1.81e-01	4.05e-01	9.07e-02
LAGGING STRAND SYNTHESIS	20	4.44e-02	1.04e-01	0.3260	0.164000	0.059700	-9.87e-02	-0.056200	-0.251000	2.05e-01	6.44e-01	4.45e-01	6.63e-01	5.23e-02
INTERLEUKIN RECEPTOR SHC SIGNALING	20	2.68e-01	3.88e-01	0.3260	-0.019200	0.169000	6.82e-02	-0.024600	0.268000	8.82e-01	1.90e-01	5.98e-01	8.49e-01	3.80e-02
PERK REGULATES GENE EXPRESSION	28	5.79e-02	1.29e-01	0.3260	0.003100	-0.018700	-1.07e-01	-0.015300	-0.307000	9.77e-01	8.64e-01	3.29e-01	8.89e-01	4.96e-03
SEPARATION OF SISTER CHROMATIDS	162	3.95e-12	9.13e-11	0.3260	0.136000	0.048400	-1.41e-01	0.148000	-0.209000	2.95e-03	2.88e-01	2.04e-03	1.15e-03	4.64e-06
MUCOPOLYSACCHARIDOSES	11	5.79e-01	6.66e-01	0.3250	0.184000	-0.084600	1.50e-01	0.131000	0.159000	2.92e-01	6.27e-01	3.88e-01	4.52e-01	3.61e-01
PARASITE INFECTION	54	1.54e-06	1.41e-05	0.3250	-0.271000	-0.068200	5.09e-02	0.131000	-0.088600	5.63e-04	3.86e-01	5.18e-01	9.66e-02	2.60e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	8.96e-02	1.75e-01	0.3250	-0.078000	-0.178000	-9.06e-02	0.083900	-0.229000	3.66e-01	3.94e-02	2.93e-01	3.30e-01	7.82e-03
G2 M DNA DAMAGE CHECKPOINT	64	6.07e-02	1.33e-01	0.3240	-0.084100	-0.165000	-1.85e-01	-0.049200	-0.186000	2.45e-01	2.26e-02	1.07e-02	4.96e-01	1.02e-02
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	3.00e-08	3.77e-07	0.3240	-0.126000	-0.049400	1.43e-01	0.035900	0.256000	4.52e-02	4.32e-01	2.32e-02	5.67e-01	4.64e-05
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	15	5.21e-01	6.19e-01	0.3240	-0.159000	-0.007500	-1.36e-01	0.046100	-0.243000	2.87e-01	9.60e-01	3.61e-01	7.57e-01	1.03e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	2.15e-01	3.31e-01	0.3240	-0.145000	-0.092800	-1.41e-01	-0.207000	-0.113000	1.32e-01	3.35e-01	1.42e-01	3.19e-02	2.43e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	3.22e-06	2.77e-05	0.3240	0.051700	0.303000	-8.60e-02	-0.047000	-0.031600	4.72e-01	2.43e-05	2.31e-01	5.13e-01	6.60e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	7.92e-01	8.38e-01	0.3230	0.202000	0.122000	1.80e-01	-0.033600	0.123000	1.75e-01	4.15e-01	2.27e-01	8.22e-01	4.11e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	9.21e-02	1.78e-01	0.3230	-0.186000	0.005950	1.03e-01	-0.199000	0.141000	1.01e-01	9.58e-01	3.66e-01	7.97e-02	2.13e-01
MRNA SPLICING MINOR PATHWAY	52	5.21e-04	2.63e-03	0.3220	0.206000	0.210000	4.92e-02	0.004540	-0.121000	1.00e-02	8.88e-03	5.39e-01	9.55e-01	1.30e-01
TRANSLESION SYNTHESIS BY POLH	19	1.99e-01	3.12e-01	0.3220	0.020000	0.021900	-1.84e-01	-0.054400	-0.257000	8.80e-01	8.69e-01	1.65e-01	6.81e-01	5.24e-02
GLYCOSAMINOGLYCAN METABOLISM	112	3.99e-06	3.42e-05	0.3220	0.161000	-0.058600	1.27e-01	0.229000	0.073300	3.32e-03	2.84e-01	1.99e-02	2.81e-05	1.81e-01
SIGNALING BY KIT IN DISEASE	20	4.46e-01	5.59e-01	0.3210	-0.108000	-0.236000	-1.83e-01	0.000453	-0.049100	4.03e-01	6.79e-02	1.56e-01	9.97e-01	7.04e-01
MRNA SPLICING	188	8.73e-19	4.39e-17	0.3210	0.104000	0.274000	-9.90e-02	0.021100	-0.082000	1.45e-02	9.05e-11	1.95e-02	6.19e-01	5.28e-02
SHC MEDIATED CASCADE FGFR1	14	3.42e-01	4.63e-01	0.3210	-0.045000	0.093300	-1.53e-01	-0.029100	-0.261000	7.71e-01	5.45e-01	3.23e-01	8.51e-01	9.11e-02
BILE ACID AND BILE SALT METABOLISM	25	4.49e-02	1.04e-01	0.3210	-0.051600	0.179000	1.03e-02	0.101000	0.240000	6.55e-01	1.21e-01	9.29e-01	3.81e-01	3.75e-02
NEPHRIN FAMILY INTERACTIONS	22	1.64e-01	2.74e-01	0.3210	-0.046000	0.112000	1.63e-01	0.090100	0.232000	7.09e-01	3.65e-01	1.86e-01	4.64e-01	6.01e-02
PLATELET CALCIUM HOMEOSTASIS	25	7.53e-02	1.54e-01	0.3210	-0.184000	-0.177000	5.89e-02	-0.129000	0.132000	1.12e-01	1.26e-01	6.11e-01	2.63e-01	2.52e-01
LYSOSOME VESICLE BIOGENESIS	32	1.08e-01	2.00e-01	0.3210	0.080300	0.042600	-2.11e-02	0.292000	-0.093600	4.32e-01	6.76e-01	8.36e-01	4.26e-03	3.60e-01
DNA METHYLATION	19	2.91e-02	7.54e-02	0.3200	0.131000	0.016100	1.83e-01	-0.139000	-0.180000	3.22e-01	9.04e-01	1.67e-01	2.94e-01	1.74e-01
G2 M CHECKPOINTS	130	1.30e-07	1.44e-06	0.3200	0.056800	-0.061200	-1.76e-01	0.048500	-0.249000	2.64e-01	2.29e-01	5.30e-04	3.40e-01	9.20e-07
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	73	7.94e-02	1.60e-01	0.3200	-0.199000	-0.152000	-1.54e-01	-0.055600	-0.115000	3.28e-03	2.52e-02	2.34e-02	4.12e-01	9.09e-02
CONSTITUTIVE SIGNALING BY EGFRVIII	15	5.20e-01	6.19e-01	0.3200	-0.268000	-0.074200	-1.53e-01	-0.039300	0.011700	7.28e-02	6.19e-01	3.06e-01	7.92e-01	9.37e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	12	3.13e-01	4.36e-01	0.3190	-0.056200	0.146000	-8.27e-02	-0.153000	-0.217000	7.36e-01	3.81e-01	6.20e-01	3.58e-01	1.94e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	3.99e-02	9.45e-02	0.3190	0.172000	0.093600	-1.98e-02	0.068800	-0.241000	1.37e-01	4.18e-01	8.64e-01	5.52e-01	3.69e-02
SIALIC ACID METABOLISM	32	6.23e-02	1.35e-01	0.3190	-0.104000	-0.156000	-9.72e-03	0.188000	-0.176000	3.08e-01	1.26e-01	9.24e-01	6.58e-02	8.54e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH	59	1.53e-02	4.61e-02	0.3180	0.013600	0.073200	2.27e-01	-0.063800	0.200000	8.57e-01	3.31e-01	2.61e-03	3.97e-01	7.83e-03
RRNA PROCESSING IN THE MITOCHONDRION	10	4.92e-01	5.94e-01	0.3180	0.140000	0.026700	-7.48e-02	0.054800	-0.269000	4.43e-01	8.84e-01	6.82e-01	7.64e-01	1.41e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	2.13e-02	5.96e-02	0.3180	-0.162000	-0.084600	2.04e-01	0.064200	0.148000	2.00e-01	5.02e-01	1.06e-01	6.11e-01	2.41e-01
SIGNALING BY PDGFR IN DISEASE	20	3.79e-01	4.98e-01	0.3180	-0.208000	-0.105000	-2.13e-01	-0.033200	0.011000	1.07e-01	4.16e-01	1.00e-01	7.97e-01	9.32e-01
MITOTIC METAPHASE AND ANAPHASE	202	3.40e-13	1.01e-11	0.3160	0.113000	0.041800	-1.36e-01	0.167000	-0.198000	5.75e-03	3.07e-01	9.05e-04	4.28e-05	1.23e-06
INHIBITION OF DNA RECOMBINATION AT TELOMERE	34	1.46e-03	6.34e-03	0.3160	0.147000	-0.023300	4.64e-02	-0.046300	-0.271000	1.37e-01	8.15e-01	6.40e-01	6.40e-01	6.30e-03
ACTIVATION OF BH3 ONLY PROTEINS	28	1.31e-01	2.32e-01	0.3160	-0.122000	-0.176000	-3.95e-02	0.206000	-0.099300	2.65e-01	1.07e-01	7.18e-01	5.90e-02	3.63e-01
DNA STRAND ELONGATION	32	1.98e-02	5.62e-02	0.3150	0.076100	-0.045000	-5.76e-02	0.005920	-0.297000	4.56e-01	6.60e-01	5.73e-01	9.54e-01	3.63e-03
SMOOTH MUSCLE CONTRACTION	33	3.14e-02	7.94e-02	0.3150	-0.002090	0.287000	-1.01e-02	-0.063900	0.112000	9.83e-01	4.34e-03	9.20e-01	5.25e-01	2.64e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	51	9.81e-03	3.21e-02	0.3150	0.179000	-0.042700	9.95e-02	0.190000	0.138000	2.67e-02	5.98e-01	2.19e-01	1.87e-02	8.92e-02
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	21	4.72e-02	1.09e-01	0.3150	0.190000	-0.002260	8.59e-02	0.019300	-0.235000	1.32e-01	9.86e-01	4.96e-01	8.78e-01	6.26e-02
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	1.33e-01	2.35e-01	0.3140	0.114000	-0.050600	-1.06e-01	-0.047800	-0.264000	3.90e-01	7.02e-01	4.24e-01	7.18e-01	4.62e-02
ERBB2 REGULATES CELL MOTILITY	13	4.44e-01	5.58e-01	0.3140	-0.293000	-0.097200	-6.01e-02	0.010600	0.002880	6.79e-02	5.44e-01	7.08e-01	9.47e-01	9.86e-01
REGULATION OF TNFR1 SIGNALING	34	3.86e-01	5.00e-01	0.3140	0.200000	0.132000	1.12e-01	0.100000	0.135000	4.34e-02	1.82e-01	2.57e-01	3.13e-01	1.72e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	3.42e-02	8.58e-02	0.3130	0.105000	0.025900	-7.11e-02	-0.149000	-0.243000	3.83e-01	8.30e-01	5.55e-01	2.17e-01	4.38e-02
HEME BIOSYNTHESIS	13	1.58e-01	2.67e-01	0.3120	-0.009230	-0.132000	1.38e-01	0.065700	-0.238000	9.54e-01	4.09e-01	3.91e-01	6.82e-01	1.37e-01
C TYPE LECTIN RECEPTORS CLRS	111	2.60e-06	2.26e-05	0.3120	0.065900	0.012600	-1.47e-01	0.125000	-0.236000	2.31e-01	8.19e-01	7.58e-03	2.33e-02	1.77e-05
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	6.02e-03	2.08e-02	0.3120	-0.056400	-0.126000	-1.02e-01	-0.219000	-0.140000	4.43e-01	8.70e-02	1.64e-01	2.83e-03	5.60e-02
HOST INTERACTIONS OF HIV FACTORS	123	8.19e-07	7.82e-06	0.3110	0.078300	-0.006700	-1.34e-01	0.135000	-0.234000	1.34e-01	8.98e-01	1.04e-02	1.00e-02	7.85e-06
INOSITOL PHOSPHATE METABOLISM	46	2.68e-03	1.06e-02	0.3110	-0.048900	0.040200	1.86e-01	0.129000	0.204000	5.67e-01	6.38e-01	2.91e-02	1.31e-01	1.69e-02
SPHINGOLIPID METABOLISM	79	4.42e-04	2.33e-03	0.3090	0.015000	-0.013100	-1.43e-02	0.272000	-0.145000	8.18e-01	8.41e-01	8.27e-01	3.02e-05	2.57e-02
SIGNALING BY FGFR2 IIIA TM	19	6.55e-02	1.39e-01	0.3090	0.137000	0.060000	5.56e-03	-0.063300	-0.262000	3.01e-01	6.51e-01	9.67e-01	6.33e-01	4.78e-02
SIGNALING BY ERBB2 IN CANCER	24	2.76e-01	3.97e-01	0.3080	-0.272000	-0.078800	-1.18e-01	-0.018400	-0.021400	2.09e-02	5.04e-01	3.18e-01	8.76e-01	8.56e-01
MTORC1 MEDIATED SIGNALLING	24	2.43e-01	3.62e-01	0.3080	-0.007140	0.047100	-1.62e-01	0.184000	-0.181000	9.52e-01	6.90e-01	1.70e-01	1.20e-01	1.24e-01
G1 S SPECIFIC TRANSCRIPTION	26	2.69e-01	3.88e-01	0.3080	0.082800	-0.072300	-8.49e-02	0.237000	-0.138000	4.65e-01	5.23e-01	4.54e-01	3.64e-02	2.23e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	5.88e-01	6.74e-01	0.3070	-0.249000	-0.103000	-3.71e-02	-0.064000	0.128000	1.72e-01	5.72e-01	8.39e-01	7.26e-01	4.85e-01
SHC MEDIATED CASCADE FGFR3	12	3.34e-01	4.56e-01	0.3070	-0.060300	0.209000	-1.86e-01	0.067800	-0.087300	7.18e-01	2.09e-01	2.65e-01	6.84e-01	6.01e-01
SIGNALING BY ROBO RECEPTORS	205	3.84e-20	2.11e-18	0.3070	0.129000	0.172000	-1.14e-01	-0.016400	-0.186000	1.46e-03	2.37e-05	4.95e-03	6.86e-01	4.58e-06
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	3.71e-02	9.09e-02	0.3060	-0.216000	-0.093100	-1.13e-01	-0.117000	-0.109000	1.41e-03	1.69e-01	9.40e-02	8.44e-02	1.08e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	27	1.87e-01	3.00e-01	0.3060	-0.215000	0.000709	-2.86e-02	-0.196000	0.089100	5.31e-02	9.95e-01	7.97e-01	7.80e-02	4.23e-01
SIGNALING BY THE B CELL RECEPTOR BCR	103	3.54e-05	2.40e-04	0.3040	0.060400	-0.011200	-1.60e-01	0.129000	-0.216000	2.90e-01	8.45e-01	5.12e-03	2.39e-02	1.53e-04
FCERI MEDIATED CA 2 MOBILIZATION	26	8.71e-02	1.72e-01	0.3040	-0.287000	0.000232	-1.01e-01	0.002240	0.002980	1.13e-02	9.98e-01	3.74e-01	9.84e-01	9.79e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	56	1.29e-03	5.67e-03	0.3040	-0.113000	-0.197000	2.41e-02	0.178000	-0.094500	1.44e-01	1.09e-02	7.55e-01	2.15e-02	2.21e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	72	6.97e-04	3.40e-03	0.3040	-0.023500	0.072600	2.41e-01	-0.044700	0.163000	7.31e-01	2.87e-01	4.03e-04	5.12e-01	1.70e-02
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	8.05e-01	8.48e-01	0.3040	-0.110000	-0.196000	-1.20e-01	-0.164000	-0.031500	5.28e-01	2.61e-01	4.92e-01	3.47e-01	8.56e-01
HIV ELONGATION ARREST AND RECOVERY	32	9.09e-02	1.77e-01	0.3040	0.210000	0.129000	1.31e-01	-0.122000	0.000850	4.02e-02	2.08e-01	2.00e-01	2.33e-01	9.93e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	1.20e-03	5.32e-03	0.3030	0.118000	-0.059800	-3.53e-02	0.060800	-0.264000	1.36e-01	4.52e-01	6.57e-01	4.44e-01	8.97e-04
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	4.68e-01	5.75e-01	0.3030	-0.060000	-0.200000	-1.17e-01	0.175000	-0.063400	6.51e-01	1.32e-01	3.76e-01	1.86e-01	6.32e-01
EXTRACELLULAR MATRIX ORGANIZATION	234	6.03e-06	5.02e-05	0.3030	0.080200	0.162000	1.86e-01	-0.035100	0.153000	3.48e-02	1.99e-05	1.04e-06	3.56e-01	5.58e-05
DISEASES OF METABOLISM	193	6.52e-05	4.18e-04	0.3030	0.192000	0.078000	1.68e-01	0.096500	0.105000	4.24e-06	6.21e-02	5.90e-05	2.10e-02	1.20e-02
CA2 PATHWAY	56	6.18e-03	2.13e-02	0.3020	-0.226000	-0.142000	-1.32e-01	0.038900	0.038400	3.49e-03	6.63e-02	8.80e-02	6.15e-01	6.19e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	23	4.62e-01	5.71e-01	0.3020	-0.196000	-0.140000	-1.30e-01	-0.127000	0.024900	1.04e-01	2.45e-01	2.80e-01	2.94e-01	8.36e-01
CONDENSATION OF PROPHASE CHROMOSOMES	26	1.04e-01	1.95e-01	0.3020	-0.031600	-0.028400	-7.28e-02	-0.111000	-0.267000	7.80e-01	8.02e-01	5.20e-01	3.27e-01	1.83e-02
SIGNALING BY FGFR2 IN DISEASE	35	3.58e-02	8.91e-02	0.3020	-0.033900	0.022200	-1.19e-01	-0.140000	-0.236000	7.29e-01	8.20e-01	2.24e-01	1.52e-01	1.58e-02
FC EPSILON RECEPTOR FCERI SIGNALING	123	4.44e-05	2.92e-04	0.3010	0.008270	-0.019100	-1.62e-01	0.162000	-0.195000	8.74e-01	7.15e-01	1.93e-03	1.92e-03	1.97e-04
RHOA GTPASE CYCLE	140	1.57e-06	1.43e-05	0.3010	-0.017400	0.183000	1.25e-01	0.039400	0.199000	7.22e-01	1.91e-04	1.05e-02	4.22e-01	4.80e-05
NON INTEGRIN MEMBRANE ECM INTERACTIONS	55	1.21e-01	2.16e-01	0.3010	0.055900	0.190000	1.42e-01	-0.097100	0.147000	4.74e-01	1.47e-02	6.88e-02	2.13e-01	5.99e-02
G ALPHA Z SIGNALLING EVENTS	43	2.45e-02	6.64e-02	0.3010	-0.072100	-0.048300	-2.93e-02	0.263000	-0.112000	4.14e-01	5.84e-01	7.40e-01	2.82e-03	2.03e-01
RNA POLYMERASE I PROMOTER ESCAPE	46	4.61e-04	2.40e-03	0.3000	0.058500	0.033600	-2.71e-02	-0.095800	-0.275000	4.93e-01	6.94e-01	7.50e-01	2.61e-01	1.24e-03
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	23	7.22e-02	1.49e-01	0.3000	0.037100	-0.024100	-3.58e-02	-0.113000	-0.272000	7.58e-01	8.41e-01	7.67e-01	3.47e-01	2.38e-02
COSTIMULATION BY THE CD28 FAMILY	49	2.16e-01	3.32e-01	0.3000	-0.111000	-0.147000	-1.26e-01	0.106000	-0.171000	1.80e-01	7.52e-02	1.28e-01	1.99e-01	3.86e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	4.49e-01	5.62e-01	0.3000	-0.115000	-0.006120	-6.34e-02	0.141000	-0.230000	4.41e-01	9.67e-01	6.71e-01	3.45e-01	1.23e-01
G0 AND EARLY G1	24	3.68e-01	4.88e-01	0.3000	0.014800	-0.020900	-1.01e-01	0.227000	-0.166000	9.00e-01	8.59e-01	3.92e-01	5.40e-02	1.60e-01
HEDGEHOG ON STATE	82	4.72e-04	2.45e-03	0.2980	0.201000	0.135000	5.75e-04	0.155000	-0.081900	1.70e-03	3.54e-02	9.93e-01	1.54e-02	2.00e-01
REGULATION OF KIT SIGNALING	16	2.66e-01	3.86e-01	0.2980	-0.057600	-0.229000	-2.90e-02	0.166000	0.070500	6.90e-01	1.13e-01	8.41e-01	2.50e-01	6.25e-01
TCR SIGNALING	99	1.62e-05	1.21e-04	0.2980	0.085200	0.039900	-1.44e-01	0.135000	-0.203000	1.43e-01	4.93e-01	1.37e-02	2.01e-02	4.93e-04
INTERLEUKIN 1 SIGNALING	95	2.26e-06	2.00e-05	0.2980	0.180000	0.060400	-8.45e-02	0.115000	-0.180000	2.47e-03	3.09e-01	1.55e-01	5.24e-02	2.50e-03
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	1.15e-01	2.09e-01	0.2970	-0.136000	0.032800	1.25e-01	-0.021000	0.230000	2.59e-01	7.85e-01	2.99e-01	8.61e-01	5.65e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	6.76e-01	7.45e-01	0.2970	-0.105000	-0.022900	5.97e-02	-0.240000	0.124000	5.14e-01	8.86e-01	7.09e-01	1.34e-01	4.38e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	30	3.10e-01	4.33e-01	0.2960	0.156000	0.219000	7.38e-02	-0.058800	0.080900	1.40e-01	3.76e-02	4.84e-01	5.78e-01	4.43e-01
SIGNALING BY FGFR1 IN DISEASE	32	7.65e-02	1.56e-01	0.2960	-0.229000	0.007170	-1.84e-01	-0.023700	0.025800	2.48e-02	9.44e-01	7.23e-02	8.17e-01	8.00e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	7.84e-02	1.58e-01	0.2960	0.042900	0.057900	-8.13e-02	-0.042900	-0.272000	7.16e-01	6.23e-01	4.91e-01	7.16e-01	2.12e-02
ASSEMBLY OF THE HIV VIRION	16	5.21e-01	6.19e-01	0.2950	0.178000	0.094000	1.23e-01	0.151000	-0.094700	2.19e-01	5.15e-01	3.93e-01	2.97e-01	5.12e-01
RHO GTPASES ACTIVATE CIT	18	4.54e-01	5.66e-01	0.2950	-0.012500	0.246000	7.74e-02	-0.103000	0.101000	9.27e-01	7.11e-02	5.70e-01	4.50e-01	4.60e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	3.88e-02	9.33e-02	0.2950	0.123000	0.091700	-4.60e-02	-0.090900	-0.230000	2.95e-01	4.37e-01	6.97e-01	4.41e-01	5.08e-02
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	2.04e-01	3.18e-01	0.2940	0.177000	0.129000	-1.15e-02	-0.090500	-0.174000	2.35e-01	3.87e-01	9.39e-01	5.44e-01	2.44e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	1.58e-01	2.67e-01	0.2940	-0.165000	0.045000	-1.36e-01	-0.072000	0.182000	2.25e-01	7.41e-01	3.16e-01	5.97e-01	1.82e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	4.42e-02	1.03e-01	0.2930	-0.185000	-0.053300	1.24e-01	0.147000	0.110000	1.52e-01	6.80e-01	3.38e-01	2.54e-01	3.97e-01
ERK MAPK TARGETS	22	7.32e-02	1.51e-01	0.2930	-0.136000	-0.147000	7.24e-02	0.016300	-0.201000	2.70e-01	2.33e-01	5.57e-01	8.95e-01	1.03e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.55e-01	6.47e-01	0.2930	-0.132000	0.147000	1.14e-01	-0.086400	0.161000	4.29e-01	3.77e-01	4.93e-01	6.04e-01	3.33e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	86	4.63e-03	1.69e-02	0.2930	0.142000	0.117000	5.07e-02	0.221000	-0.016400	2.30e-02	6.02e-02	4.17e-01	3.93e-04	7.93e-01
SIGNALING BY NODAL	14	3.83e-01	4.99e-01	0.2920	-0.109000	0.047900	1.29e-01	-0.232000	-0.019400	4.81e-01	7.56e-01	4.04e-01	1.32e-01	9.00e-01
RHOBTB GTPASE CYCLE	35	2.00e-02	5.66e-02	0.2910	-0.106000	0.124000	-2.09e-01	0.102000	-0.064000	2.78e-01	2.05e-01	3.27e-02	2.99e-01	5.12e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	104	9.48e-03	3.12e-02	0.2910	0.060100	0.130000	2.00e-01	-0.042100	0.150000	2.90e-01	2.24e-02	4.40e-04	4.58e-01	8.40e-03
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	2.92e-01	4.16e-01	0.2900	0.057400	-0.006100	-1.63e-01	0.087800	-0.216000	6.34e-01	9.60e-01	1.76e-01	4.66e-01	7.29e-02
ACYL CHAIN REMODELLING OF PE	16	3.66e-01	4.86e-01	0.2900	-0.121000	-0.132000	-4.68e-03	0.226000	-0.028500	4.02e-01	3.60e-01	9.74e-01	1.17e-01	8.44e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	2.85e-02	7.46e-02	0.2900	-0.160000	0.072300	1.60e-01	0.116000	0.118000	1.83e-01	5.49e-01	1.83e-01	3.37e-01	3.27e-01
REGULATED NECROSIS	45	4.87e-02	1.12e-01	0.2890	0.008750	-0.018800	-1.62e-01	0.014500	-0.238000	9.19e-01	8.28e-01	6.02e-02	8.67e-01	5.68e-03
SIGNALING BY NTRK3 TRKC	17	5.47e-01	6.41e-01	0.2890	-0.010200	0.123000	7.07e-02	-0.051000	0.247000	9.42e-01	3.80e-01	6.14e-01	7.16e-01	7.83e-02
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	2.97e-02	7.61e-02	0.2890	0.096600	0.017400	-8.96e-02	-0.005660	-0.257000	3.37e-01	8.63e-01	3.73e-01	9.55e-01	1.07e-02
INTERLEUKIN 6 FAMILY SIGNALING	18	7.11e-01	7.72e-01	0.2880	0.067400	0.124000	1.96e-01	0.076000	0.139000	6.21e-01	3.64e-01	1.51e-01	5.77e-01	3.08e-01
POLO LIKE KINASE MEDIATED EVENTS	13	4.63e-01	5.71e-01	0.2880	0.107000	0.234000	-2.19e-02	0.068400	-0.109000	5.03e-01	1.45e-01	8.91e-01	6.69e-01	4.97e-01
SYNTHESIS OF PC	24	3.08e-01	4.30e-01	0.2880	0.048500	0.066700	5.54e-02	0.268000	0.034300	6.81e-01	5.71e-01	6.39e-01	2.29e-02	7.71e-01
SHC1 EVENTS IN ERBB4 SIGNALING	12	8.55e-01	8.89e-01	0.2880	-0.175000	-0.103000	-1.42e-01	0.099700	-0.108000	2.94e-01	5.36e-01	3.93e-01	5.50e-01	5.19e-01
FRS MEDIATED FGFR2 SIGNALING	17	4.85e-01	5.87e-01	0.2870	-0.068400	0.053600	-1.91e-01	-0.041500	-0.191000	6.25e-01	7.02e-01	1.72e-01	7.67e-01	1.72e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	1.69e-01	2.79e-01	0.2870	-0.143000	0.121000	6.48e-02	0.125000	0.165000	3.07e-01	3.88e-01	6.44e-01	3.73e-01	2.38e-01
INFLAMMASOMES	18	1.52e-01	2.60e-01	0.2860	0.112000	-0.048300	-1.44e-01	-0.151000	-0.154000	4.11e-01	7.23e-01	2.89e-01	2.68e-01	2.59e-01
THE PHOTOTRANSDUCTION CASCADE	19	3.85e-01	5.00e-01	0.2860	-0.145000	-0.026500	-2.44e-01	0.016700	-0.021800	2.74e-01	8.42e-01	6.57e-02	9.00e-01	8.70e-01
RAC1 GTPASE CYCLE	175	2.22e-12	5.45e-11	0.2860	-0.135000	0.113000	1.36e-01	-0.012600	0.180000	2.18e-03	1.03e-02	1.89e-03	7.74e-01	4.19e-05
POTASSIUM CHANNELS	88	1.03e-07	1.16e-06	0.2860	-0.251000	-0.098200	5.29e-02	0.039600	0.067400	4.61e-05	1.11e-01	3.91e-01	5.21e-01	2.75e-01
METABOLISM OF NUCLEOTIDES	91	9.37e-04	4.32e-03	0.2860	0.107000	-0.078600	-5.41e-02	0.198000	-0.148000	7.84e-02	1.95e-01	3.72e-01	1.08e-03	1.50e-02
GAP JUNCTION DEGRADATION	11	6.14e-01	6.97e-01	0.2860	0.006870	0.107000	7.89e-02	0.247000	-0.053300	9.69e-01	5.39e-01	6.51e-01	1.56e-01	7.59e-01
SIGNALING BY NOTCH4	83	2.47e-05	1.71e-04	0.2850	0.157000	0.038700	-6.55e-02	0.075700	-0.213000	1.38e-02	5.42e-01	3.03e-01	2.33e-01	7.92e-04
METABOLISM OF CARBOHYDRATES	254	8.98e-10	1.44e-08	0.2850	0.152000	-0.012200	1.07e-01	0.215000	0.015200	3.20e-05	7.38e-01	3.24e-03	3.64e-09	6.78e-01
REGULATION OF BETA CELL DEVELOPMENT	23	2.60e-02	6.88e-02	0.2850	-0.134000	-0.073600	2.20e-01	-0.099000	0.000947	2.67e-01	5.41e-01	6.84e-02	4.11e-01	9.94e-01
TRIGLYCERIDE METABOLISM	22	4.61e-01	5.70e-01	0.2850	-0.069600	-0.043500	-8.69e-02	0.128000	-0.225000	5.72e-01	7.24e-01	4.81e-01	2.99e-01	6.82e-02
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	116	6.20e-05	4.00e-04	0.2840	0.034800	0.049100	1.92e-01	0.124000	0.158000	5.18e-01	3.62e-01	3.52e-04	2.17e-02	3.30e-03
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	5.71e-01	6.61e-01	0.2840	0.067000	0.116000	1.67e-01	0.006860	0.187000	5.25e-01	2.73e-01	1.14e-01	9.48e-01	7.60e-02
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	1.61e-02	4.80e-02	0.2840	0.108000	0.144000	-5.48e-02	-0.135000	-0.164000	2.97e-01	1.66e-01	5.97e-01	1.93e-01	1.13e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	2.68e-01	3.88e-01	0.2840	-0.221000	-0.118000	-9.13e-02	-0.097000	-0.005970	1.98e-02	2.15e-01	3.37e-01	3.07e-01	9.50e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	31	4.48e-02	1.04e-01	0.2840	0.116000	0.061000	-1.04e-01	0.027800	-0.227000	2.63e-01	5.57e-01	3.18e-01	7.89e-01	2.85e-02
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	14	8.43e-01	8.78e-01	0.2830	0.156000	0.155000	1.72e-01	-0.004360	0.048100	3.12e-01	3.14e-01	2.66e-01	9.77e-01	7.55e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	11	5.18e-01	6.18e-01	0.2820	-0.077400	0.178000	-1.56e-01	-0.132000	0.017900	6.57e-01	3.08e-01	3.72e-01	4.48e-01	9.18e-01
METABOLISM OF FOLATE AND PTERINES	15	8.90e-01	9.12e-01	0.2820	0.160000	0.101000	1.59e-01	0.099500	0.093400	2.84e-01	4.98e-01	2.88e-01	5.05e-01	5.31e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	11	5.34e-01	6.30e-01	0.2820	-0.062400	0.024800	-3.73e-02	-0.069100	-0.262000	7.20e-01	8.87e-01	8.30e-01	6.91e-01	1.32e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	2.21e-01	3.35e-01	0.2820	-0.116000	-0.178000	1.31e-01	0.040200	-0.125000	4.54e-01	2.49e-01	3.97e-01	7.95e-01	4.20e-01
G ALPHA 12 13 SIGNALLING EVENTS	74	1.21e-03	5.32e-03	0.2810	-0.034200	0.068000	2.12e-01	0.009680	0.168000	6.11e-01	3.12e-01	1.63e-03	8.86e-01	1.23e-02
FGFR1 MUTANT RECEPTOR ACTIVATION	25	1.22e-01	2.17e-01	0.2810	-0.198000	0.071900	-1.74e-01	-0.041100	0.053900	8.70e-02	5.34e-01	1.33e-01	7.22e-01	6.41e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	1.42e-01	2.46e-01	0.2810	-0.066400	0.132000	1.38e-01	-0.122000	0.152000	4.85e-01	1.65e-01	1.47e-01	1.98e-01	1.09e-01
METABOLISM OF PORPHYRINS	19	7.12e-02	1.48e-01	0.2810	-0.019500	-0.079900	1.21e-01	0.035600	-0.237000	8.83e-01	5.47e-01	3.61e-01	7.89e-01	7.37e-02
MEIOTIC RECOMBINATION	36	4.89e-01	5.91e-01	0.2810	-0.115000	-0.132000	-1.18e-01	-0.096000	-0.158000	2.32e-01	1.71e-01	2.21e-01	3.19e-01	1.01e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	6.57e-01	7.31e-01	0.2800	-0.213000	-0.053400	-1.82e-02	-0.172000	-0.018100	1.52e-01	7.20e-01	9.03e-01	2.50e-01	9.04e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	105	9.74e-04	4.42e-03	0.2800	0.087900	0.029200	1.41e-01	0.192000	0.113000	1.20e-01	6.05e-01	1.28e-02	6.64e-04	4.53e-02
CELL CYCLE CHECKPOINTS	236	2.20e-09	3.31e-08	0.2800	0.024300	-0.044400	-1.75e-01	0.070700	-0.200000	5.22e-01	2.41e-01	3.89e-06	6.18e-02	1.23e-07
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	7.07e-04	3.42e-03	0.2790	0.051900	-0.123000	2.45e-02	0.144000	-0.197000	4.34e-01	6.45e-02	7.12e-01	2.98e-02	3.00e-03
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	2.65e-01	3.86e-01	0.2790	-0.017000	0.208000	8.29e-02	-0.112000	0.122000	8.70e-01	4.50e-02	4.25e-01	2.81e-01	2.41e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	26	3.55e-01	4.77e-01	0.2790	0.033500	-0.024400	-2.64e-02	0.253000	-0.107000	7.68e-01	8.29e-01	8.16e-01	2.56e-02	3.47e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	1.76e-01	2.87e-01	0.2790	-0.118000	-0.149000	1.14e-01	0.115000	0.124000	3.99e-01	2.88e-01	4.14e-01	4.12e-01	3.77e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	12	4.61e-01	5.70e-01	0.2790	-0.037500	0.206000	1.66e-01	0.077400	0.021800	8.22e-01	2.17e-01	3.20e-01	6.42e-01	8.96e-01
PYRIMIDINE CATABOLISM	10	6.31e-01	7.12e-01	0.2780	0.030100	-0.272000	-3.29e-03	-0.027900	-0.044900	8.69e-01	1.37e-01	9.86e-01	8.79e-01	8.06e-01
HS GAG BIOSYNTHESIS	29	1.09e-01	2.00e-01	0.2780	0.200000	-0.054000	-1.10e-02	0.179000	0.047600	6.25e-02	6.15e-01	9.18e-01	9.58e-02	6.57e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	148	9.27e-11	1.70e-09	0.2780	0.138000	0.097300	-7.49e-02	0.019000	-0.206000	3.81e-03	4.13e-02	1.16e-01	6.91e-01	1.49e-05
RHO GTPASES ACTIVATE NADPH OXIDASES	18	1.04e-01	1.95e-01	0.2780	-0.124000	0.058000	9.93e-02	0.212000	-0.059000	3.62e-01	6.70e-01	4.66e-01	1.19e-01	6.65e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	28	2.80e-01	4.00e-01	0.2780	0.064400	0.043200	5.31e-04	0.240000	-0.116000	5.55e-01	6.93e-01	9.96e-01	2.81e-02	2.88e-01
CYTOPROTECTION BY HMOX1	118	1.99e-08	2.65e-07	0.2770	0.135000	0.102000	-7.47e-02	0.017600	-0.205000	1.14e-02	5.69e-02	1.62e-01	7.42e-01	1.19e-04
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	41	6.90e-02	1.45e-01	0.2760	-0.081000	0.057000	-1.29e-01	-0.209000	-0.076500	3.69e-01	5.28e-01	1.52e-01	2.08e-02	3.97e-01
HIV INFECTION	219	3.46e-10	5.80e-09	0.2760	0.064100	0.005860	-1.17e-01	0.102000	-0.218000	1.03e-01	8.81e-01	2.85e-03	9.16e-03	2.82e-08
PROCESSING OF INTRONLESS PRE MRNAS	19	1.93e-01	3.05e-01	0.2750	-0.135000	0.196000	-1.32e-01	-0.031700	-0.022800	3.07e-01	1.39e-01	3.19e-01	8.11e-01	8.64e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	24	3.24e-01	4.45e-01	0.2750	-0.185000	0.066000	-1.67e-01	-0.059000	-0.075700	1.17e-01	5.76e-01	1.58e-01	6.17e-01	5.21e-01
FRS MEDIATED FGFR4 SIGNALING	12	5.42e-01	6.37e-01	0.2750	-0.041400	0.025800	-2.45e-01	0.104000	-0.046800	8.04e-01	8.77e-01	1.42e-01	5.31e-01	7.79e-01
STRIATED MUSCLE CONTRACTION	23	3.55e-01	4.77e-01	0.2740	0.001350	0.140000	8.46e-02	-0.219000	0.027100	9.91e-01	2.46e-01	4.83e-01	6.92e-02	8.22e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	2.70e-03	1.07e-02	0.2740	0.076500	-0.096700	4.81e-02	0.146000	-0.191000	2.98e-01	1.88e-01	5.13e-01	4.69e-02	9.49e-03
NEDDYLATION	214	3.58e-08	4.46e-07	0.2740	0.075300	-0.103000	-6.02e-02	0.162000	-0.170000	5.80e-02	9.78e-03	1.30e-01	4.60e-05	1.92e-05
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	3.33e-01	4.55e-01	0.2730	-0.067900	-0.128000	2.22e-01	-0.018000	-0.065300	7.10e-01	4.84e-01	2.25e-01	9.22e-01	7.21e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	7.92e-01	8.38e-01	0.2730	0.071200	0.006600	1.16e-01	0.232000	0.046900	6.83e-01	9.70e-01	5.07e-01	1.84e-01	7.88e-01
UCH PROTEINASES	88	8.20e-06	6.65e-05	0.2720	0.190000	0.065500	-2.45e-02	0.034500	-0.179000	2.12e-03	2.89e-01	6.92e-01	5.76e-01	3.64e-03
FGFR2 ALTERNATIVE SPLICING	25	1.98e-01	3.11e-01	0.2720	0.165000	0.202000	2.76e-02	-0.014500	-0.071900	1.53e-01	8.06e-02	8.11e-01	9.00e-01	5.34e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	2.15e-01	3.31e-01	0.2720	-0.205000	-0.141000	-6.29e-02	-0.088700	-0.015000	2.03e-02	1.09e-01	4.75e-01	3.14e-01	8.65e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	5.99e-01	6.82e-01	0.2720	-0.025500	0.053300	-8.08e-02	0.237000	-0.086100	8.64e-01	7.21e-01	5.88e-01	1.11e-01	5.64e-01
METABOLISM OF STEROID HORMONES	19	1.32e-01	2.32e-01	0.2720	0.228000	0.010400	-6.61e-02	-0.027900	-0.128000	8.54e-02	9.38e-01	6.18e-01	8.34e-01	3.32e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	1.79e-01	2.90e-01	0.2710	0.012600	-0.072700	-4.12e-02	0.257000	0.022100	9.06e-01	4.98e-01	7.01e-01	1.67e-02	8.37e-01
MAPK6 MAPK4 SIGNALING	83	2.15e-04	1.22e-03	0.2710	0.112000	0.049500	-9.89e-02	0.087400	-0.203000	7.87e-02	4.36e-01	1.20e-01	1.69e-01	1.41e-03
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	9.02e-02	1.76e-01	0.2710	0.066800	-0.007140	5.62e-03	-0.106000	-0.240000	5.79e-01	9.53e-01	9.63e-01	3.79e-01	4.62e-02
CARDIAC CONDUCTION	102	5.32e-07	5.25e-06	0.2710	-0.206000	-0.057100	1.07e-01	-0.098600	0.079100	3.23e-04	3.19e-01	6.11e-02	8.55e-02	1.68e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	21	5.25e-01	6.23e-01	0.2690	0.029900	-0.009250	-1.02e-01	0.228000	-0.096500	8.12e-01	9.42e-01	4.20e-01	7.08e-02	4.44e-01
TRAFFICKING OF AMPA RECEPTORS	31	2.90e-02	7.52e-02	0.2690	-0.147000	0.012100	1.18e-01	0.060800	0.182000	1.56e-01	9.07e-01	2.57e-01	5.58e-01	7.95e-02
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	3.09e-02	7.86e-02	0.2690	0.050000	-0.032800	-1.43e-02	0.239000	-0.107000	4.93e-01	6.53e-01	8.45e-01	1.06e-03	1.40e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	6.81e-01	7.48e-01	0.2690	-0.142000	-0.142000	-8.78e-02	0.008770	-0.154000	2.09e-01	2.10e-01	4.39e-01	9.38e-01	1.73e-01
SARS COV 2 INFECTION	65	2.17e-02	6.04e-02	0.2680	0.070700	-0.045900	-2.36e-02	0.191000	-0.167000	3.25e-01	5.22e-01	7.42e-01	7.71e-03	2.00e-02
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	2.43e-01	3.62e-01	0.2680	-0.111000	-0.005000	-1.12e-01	0.212000	-0.045900	3.26e-01	9.65e-01	3.21e-01	6.16e-02	6.86e-01
GLUCAGON TYPE LIGAND RECEPTORS	23	5.52e-01	6.45e-01	0.2680	0.015200	-0.061700	-1.20e-01	0.093400	-0.212000	8.99e-01	6.08e-01	3.21e-01	4.38e-01	7.90e-02
TBC RABGAPS	43	2.15e-02	5.99e-02	0.2680	0.105000	-0.032300	1.54e-01	0.160000	-0.102000	2.36e-01	7.14e-01	8.10e-02	6.90e-02	2.49e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	92	2.54e-04	1.42e-03	0.2670	0.136000	0.053300	-9.66e-02	0.146000	-0.139000	2.45e-02	3.78e-01	1.10e-01	1.57e-02	2.17e-02
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	46	4.01e-03	1.50e-02	0.2670	0.052400	0.058100	2.63e-02	-0.208000	-0.145000	5.39e-01	4.95e-01	7.57e-01	1.49e-02	8.79e-02
MRNA CAPPING	29	8.25e-02	1.64e-01	0.2660	0.069500	0.009230	-3.03e-02	0.008160	-0.255000	5.17e-01	9.31e-01	7.78e-01	9.39e-01	1.75e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	7.65e-01	8.19e-01	0.2660	0.024200	-0.151000	-1.32e-01	0.107000	-0.137000	8.71e-01	3.13e-01	3.76e-01	4.74e-01	3.60e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	6.20e-01	7.02e-01	0.2660	-0.094600	-0.042000	1.45e-01	-0.103000	0.168000	5.55e-01	7.93e-01	3.65e-01	5.22e-01	2.94e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	6.33e-01	7.12e-01	0.2650	-0.069400	-0.094900	-1.49e-01	0.125000	-0.138000	5.25e-01	3.85e-01	1.73e-01	2.54e-01	2.07e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	1.67e-01	2.75e-01	0.2650	0.037700	-0.035600	2.22e-01	0.114000	0.074500	7.40e-01	7.53e-01	5.02e-02	3.17e-01	5.11e-01
CILIUM ASSEMBLY	189	4.63e-07	4.77e-06	0.2650	0.156000	0.121000	-1.92e-03	0.157000	0.081100	2.14e-04	4.27e-03	9.64e-01	2.02e-04	5.49e-02
INWARDLY RECTIFYING K CHANNELS	31	3.82e-01	4.98e-01	0.2640	-0.162000	-0.093300	-8.26e-02	0.106000	-0.128000	1.18e-01	3.69e-01	4.26e-01	3.05e-01	2.17e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	183	1.53e-06	1.41e-05	0.2640	0.090600	-0.024200	5.27e-02	0.241000	0.000994	3.48e-02	5.72e-01	2.20e-01	2.06e-08	9.82e-01
SYNDECAN INTERACTIONS	26	3.28e-01	4.50e-01	0.2630	0.063000	0.245000	1.38e-02	0.025200	0.067800	5.78e-01	3.09e-02	9.03e-01	8.24e-01	5.49e-01
INTEGRIN CELL SURFACE INTERACTIONS	68	9.83e-03	3.21e-02	0.2620	-0.025200	0.143000	6.77e-02	-0.206000	0.029800	7.19e-01	4.14e-02	3.35e-01	3.37e-03	6.71e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	20	1.81e-01	2.92e-01	0.2620	0.028900	-0.087200	5.20e-02	-0.150000	-0.187000	8.23e-01	5.00e-01	6.87e-01	2.44e-01	1.47e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	2.32e-16	1.03e-14	0.2620	0.064200	0.223000	-9.67e-02	0.006600	-0.075900	8.94e-02	3.76e-09	1.05e-02	8.61e-01	4.45e-02
PLATELET AGGREGATION PLUG FORMATION	31	3.16e-01	4.37e-01	0.2620	0.036600	0.107000	2.04e-01	0.067800	0.099500	7.24e-01	3.03e-01	4.98e-02	5.14e-01	3.38e-01
INTEGRATION OF ENERGY METABOLISM	96	3.77e-04	2.04e-03	0.2620	0.019300	0.028200	1.02e-01	0.210000	0.114000	7.44e-01	6.33e-01	8.38e-02	3.86e-04	5.30e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	25	2.56e-01	3.77e-01	0.2620	0.032500	0.108000	-8.14e-02	0.132000	-0.178000	7.78e-01	3.48e-01	4.81e-01	2.54e-01	1.23e-01
INTEGRIN SIGNALING	24	3.81e-01	4.98e-01	0.2620	-0.012700	0.099700	1.88e-01	0.057700	0.141000	9.14e-01	3.98e-01	1.11e-01	6.25e-01	2.33e-01
FCGR3A MEDIATED IL10 SYNTHESIS	32	2.88e-02	7.51e-02	0.2610	-0.125000	0.034200	3.80e-02	0.157000	0.158000	2.21e-01	7.38e-01	7.10e-01	1.24e-01	1.21e-01
DNA DAMAGE RECOGNITION IN GG NER	38	3.76e-02	9.14e-02	0.2610	0.140000	0.006210	8.50e-02	0.095900	-0.178000	1.34e-01	9.47e-01	3.65e-01	3.07e-01	5.71e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	7.38e-01	7.96e-01	0.2590	0.034000	0.099800	-1.25e-01	0.062700	-0.191000	8.52e-01	5.85e-01	4.95e-01	7.31e-01	2.95e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	1.19e-01	2.14e-01	0.2590	0.198000	0.140000	4.07e-03	-0.043300	-0.079900	6.99e-02	2.01e-01	9.70e-01	6.92e-01	4.65e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	1.05e-01	1.96e-01	0.2580	-0.092000	0.036500	-1.07e-02	0.233000	0.047300	4.00e-01	7.38e-01	9.22e-01	3.27e-02	6.65e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	3.71e-01	4.91e-01	0.2580	-0.114000	-0.000678	1.20e-01	-0.137000	0.142000	3.43e-01	9.96e-01	3.17e-01	2.54e-01	2.39e-01
SARS COV 1 INFECTION	48	4.57e-02	1.06e-01	0.2580	0.074700	0.060500	-2.56e-02	0.150000	-0.184000	3.71e-01	4.68e-01	7.59e-01	7.23e-02	2.72e-02
SEMAPHORIN INTERACTIONS	64	1.68e-01	2.78e-01	0.2570	0.026300	0.088300	1.33e-01	-0.089200	0.179000	7.16e-01	2.22e-01	6.67e-02	2.17e-01	1.31e-02
P75 NTR RECEPTOR MEDIATED SIGNALLING	93	1.53e-04	9.01e-04	0.2570	-0.032500	0.061200	2.20e-01	-0.007380	0.115000	5.89e-01	3.08e-01	2.55e-04	9.02e-01	5.64e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	8.35e-01	8.73e-01	0.2570	-0.075200	-0.075800	-1.50e-01	0.098000	-0.150000	5.71e-01	5.68e-01	2.57e-01	4.60e-01	2.57e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	2.90e-01	4.13e-01	0.2570	-0.041100	0.071000	5.15e-02	-0.113000	0.209000	6.88e-01	4.87e-01	6.14e-01	2.68e-01	4.04e-02
CD28 DEPENDENT PI3K AKT SIGNALING	20	2.98e-01	4.21e-01	0.2570	0.019100	-0.201000	2.06e-02	0.148000	0.051900	8.82e-01	1.20e-01	8.73e-01	2.51e-01	6.88e-01
OPIOID SIGNALLING	85	2.00e-04	1.14e-03	0.2560	-0.185000	-0.074400	-5.74e-02	0.150000	0.006480	3.14e-03	2.36e-01	3.61e-01	1.69e-02	9.18e-01
PRE NOTCH EXPRESSION AND PROCESSING	62	1.74e-02	5.08e-02	0.2560	-0.025800	0.001500	1.94e-01	-0.088300	0.139000	7.25e-01	9.84e-01	8.14e-03	2.29e-01	5.84e-02
FATTY ACID METABOLISM	143	1.40e-05	1.06e-04	0.2560	0.061800	0.036000	-3.77e-02	0.163000	-0.180000	2.03e-01	4.58e-01	4.37e-01	7.75e-04	2.06e-04
METABOLISM OF RNA	642	6.04e-44	3.49e-41	0.2560	0.112000	0.155000	-9.16e-02	-0.005020	-0.143000	1.35e-06	2.64e-11	8.15e-05	8.29e-01	8.06e-10
NEGATIVE REGULATION OF FLT3	14	9.06e-01	9.25e-01	0.2560	0.078400	0.109000	1.33e-01	-0.119000	0.124000	6.12e-01	4.81e-01	3.87e-01	4.39e-01	4.23e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	62	6.17e-04	3.04e-03	0.2550	0.195000	-0.027900	9.06e-02	-0.017300	-0.134000	7.89e-03	7.05e-01	2.17e-01	8.14e-01	6.88e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	21	5.73e-01	6.61e-01	0.2550	0.013500	0.017200	-1.27e-01	0.132000	-0.177000	9.15e-01	8.91e-01	3.15e-01	2.96e-01	1.60e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	2.59e-01	3.80e-01	0.2550	0.025900	0.044500	2.26e-01	0.072900	0.077500	8.19e-01	6.95e-01	4.59e-02	5.20e-01	4.94e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	21	4.65e-01	5.73e-01	0.2550	0.002950	-0.119000	-1.12e-01	-0.158000	-0.116000	9.81e-01	3.47e-01	3.74e-01	2.10e-01	3.56e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	3.31e-01	4.53e-01	0.2550	0.038600	0.007710	-1.40e-01	0.013200	-0.209000	7.38e-01	9.47e-01	2.26e-01	9.09e-01	7.12e-02
MET PROMOTES CELL MOTILITY	38	2.69e-01	3.89e-01	0.2540	-0.027500	0.148000	8.28e-02	-0.054100	0.180000	7.69e-01	1.15e-01	3.78e-01	5.64e-01	5.48e-02
EPHB MEDIATED FORWARD SIGNALING	42	3.06e-02	7.81e-02	0.2540	-0.108000	-0.115000	3.98e-02	0.152000	-0.121000	2.26e-01	1.96e-01	6.55e-01	8.77e-02	1.74e-01
DUAL INCISION IN TC NER	64	1.39e-03	6.07e-03	0.2540	0.048200	-0.011100	-4.79e-02	-0.082600	-0.230000	5.05e-01	8.78e-01	5.08e-01	2.53e-01	1.48e-03
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	69	1.09e-01	2.00e-01	0.2540	-0.044600	-0.129000	-1.35e-01	-0.080200	-0.145000	5.22e-01	6.35e-02	5.20e-02	2.50e-01	3.77e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	8.93e-01	9.14e-01	0.2540	-0.084000	-0.186000	-1.03e-01	0.105000	-0.037200	6.45e-01	3.10e-01	5.74e-01	5.67e-01	8.39e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	5.94e-02	1.32e-01	0.2530	0.165000	0.089900	8.01e-02	-0.009560	-0.150000	1.02e-01	3.72e-01	4.26e-01	9.24e-01	1.36e-01
CD209 DC SIGN SIGNALING	18	7.07e-01	7.69e-01	0.2530	-0.159000	-0.075300	-8.29e-02	0.105000	-0.124000	2.43e-01	5.80e-01	5.43e-01	4.41e-01	3.64e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	10	6.52e-01	7.27e-01	0.2530	0.186000	-0.148000	-3.80e-03	0.080400	-0.030700	3.08e-01	4.18e-01	9.83e-01	6.60e-01	8.66e-01
PLATELET SENSITIZATION BY LDL	15	6.90e-01	7.54e-01	0.2530	0.016300	0.049200	-3.72e-02	0.200000	-0.142000	9.13e-01	7.42e-01	8.03e-01	1.81e-01	3.42e-01
NICOTINAMIDE SALVAGING	14	4.12e-01	5.25e-01	0.2530	-0.017500	0.127000	-1.79e-02	-0.114000	-0.184000	9.10e-01	4.09e-01	9.08e-01	4.61e-01	2.32e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	175	2.86e-10	4.94e-09	0.2520	-0.114000	-0.123000	7.24e-03	0.181000	0.050500	9.45e-03	4.97e-03	8.69e-01	3.55e-05	2.50e-01
MICRORNA MIRNA BIOGENESIS	24	6.67e-01	7.39e-01	0.2520	0.138000	0.111000	1.33e-01	-0.102000	0.065800	2.41e-01	3.47e-01	2.61e-01	3.89e-01	5.77e-01
METALLOPROTEASE DUBS	24	5.12e-01	6.13e-01	0.2520	0.003000	-0.053400	-1.18e-01	-0.003950	-0.216000	9.80e-01	6.50e-01	3.16e-01	9.73e-01	6.70e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	83	4.42e-05	2.92e-04	0.2520	-0.071100	-0.126000	9.15e-02	0.180000	0.039000	2.63e-01	4.70e-02	1.50e-01	4.58e-03	5.39e-01
SIGNALING BY RETINOIC ACID	30	4.59e-01	5.70e-01	0.2510	0.015800	-0.062900	-5.60e-02	0.201000	-0.123000	8.81e-01	5.51e-01	5.95e-01	5.63e-02	2.42e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	3.83e-03	1.45e-02	0.2510	0.003960	-0.031400	-5.71e-02	0.065500	-0.233000	9.50e-01	6.21e-01	3.69e-01	3.02e-01	2.38e-04
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	77	4.97e-04	2.56e-03	0.2510	-0.069900	-0.028900	1.46e-01	0.037300	0.186000	2.89e-01	6.61e-01	2.66e-02	5.72e-01	4.86e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	22	4.08e-01	5.20e-01	0.2500	-0.126000	0.098600	-1.37e-01	-0.095000	-0.096700	3.07e-01	4.23e-01	2.66e-01	4.41e-01	4.32e-01
NEUTROPHIL DEGRANULATION	374	7.05e-13	1.85e-11	0.2500	0.075800	0.026600	-5.68e-02	0.182000	-0.140000	1.21e-02	3.79e-01	6.01e-02	1.52e-09	3.34e-06
CHROMATIN MODIFYING ENZYMES	216	1.42e-05	1.08e-04	0.2500	-0.008890	0.057600	1.32e-01	-0.139000	0.150000	8.22e-01	1.45e-01	8.26e-04	4.32e-04	1.54e-04
FANCONI ANEMIA PATHWAY	36	1.08e-01	2.00e-01	0.2500	0.163000	0.042800	1.33e-01	-0.128000	-0.018300	9.15e-02	6.57e-01	1.69e-01	1.84e-01	8.49e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	56	7.95e-02	1.60e-01	0.2500	-0.194000	-0.135000	-1.71e-02	-0.078100	-0.022100	1.23e-02	8.05e-02	8.25e-01	3.12e-01	7.75e-01
NEURONAL SYSTEM	359	4.31e-27	3.32e-25	0.2500	-0.150000	-0.076700	6.82e-02	0.120000	0.122000	1.05e-06	1.29e-02	2.70e-02	9.53e-05	7.55e-05
SENSORY PROCESSING OF SOUND	59	3.24e-01	4.45e-01	0.2500	0.049800	0.115000	1.48e-01	-0.025200	0.156000	5.08e-01	1.28e-01	4.88e-02	7.38e-01	3.88e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	1.89e-01	3.01e-01	0.2500	-0.077600	0.003330	-8.70e-02	0.165000	-0.146000	3.90e-01	9.71e-01	3.35e-01	6.74e-02	1.05e-01
FOXO MEDIATED TRANSCRIPTION	56	3.18e-01	4.39e-01	0.2490	-0.136000	-0.118000	-7.75e-02	-0.090700	-0.125000	7.82e-02	1.28e-01	3.16e-01	2.41e-01	1.07e-01
RUNX2 REGULATES BONE DEVELOPMENT	28	1.93e-01	3.05e-01	0.2490	-0.049100	-0.047800	1.01e-01	-0.001070	0.217000	6.53e-01	6.61e-01	3.53e-01	9.92e-01	4.70e-02
TRANS GOLGI NETWORK VESICLE BUDDING	69	9.07e-02	1.76e-01	0.2490	-0.027300	-0.061000	-9.76e-02	0.178000	-0.127000	6.96e-01	3.82e-01	1.61e-01	1.04e-02	6.73e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	1.48e-02	4.47e-02	0.2490	-0.185000	0.042000	2.90e-02	-0.093300	0.127000	1.85e-02	5.93e-01	7.13e-01	2.36e-01	1.05e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	1.65e-01	2.74e-01	0.2490	-0.210000	-0.110000	-3.83e-02	-0.034300	-0.056300	1.49e-02	2.03e-01	6.57e-01	6.91e-01	5.14e-01
NEUROTRANSMITTER RELEASE CYCLE	46	3.72e-03	1.42e-02	0.2480	-0.192000	0.000682	1.92e-02	0.088300	0.129000	2.45e-02	9.94e-01	8.22e-01	3.00e-01	1.29e-01
RET SIGNALING	36	1.43e-01	2.46e-01	0.2480	-0.008930	-0.017000	1.79e-01	0.044000	0.165000	9.26e-01	8.60e-01	6.36e-02	6.48e-01	8.67e-02
O LINKED GLYCOSYLATION	81	5.67e-04	2.81e-03	0.2470	0.033400	-0.094400	1.86e-01	0.071300	0.108000	6.03e-01	1.42e-01	3.92e-03	2.68e-01	9.24e-02
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	64	4.01e-04	2.15e-03	0.2470	0.067400	0.058700	-4.72e-03	-0.101000	-0.207000	3.51e-01	4.17e-01	9.48e-01	1.62e-01	4.18e-03
PROGRAMMED CELL DEATH	181	7.65e-06	6.27e-05	0.2470	0.044100	-0.009780	-1.03e-01	0.111000	-0.190000	3.07e-01	8.21e-01	1.75e-02	9.91e-03	1.10e-05
PROLACTIN RECEPTOR SIGNALING	11	8.63e-01	8.92e-01	0.2470	-0.000846	-0.030800	-8.97e-02	0.219000	-0.063600	9.96e-01	8.60e-01	6.07e-01	2.09e-01	7.15e-01
PRC2 METHYLATES HISTONES AND DNA	28	9.55e-02	1.83e-01	0.2460	0.071700	0.036900	-1.21e-02	-0.162000	-0.167000	5.12e-01	7.36e-01	9.12e-01	1.38e-01	1.27e-01
SIGNALLING TO RAS	17	7.58e-01	8.12e-01	0.2460	0.124000	0.007230	1.98e-01	0.020200	0.074000	3.77e-01	9.59e-01	1.58e-01	8.85e-01	5.97e-01
MITOTIC SPINDLE CHECKPOINT	94	1.20e-02	3.75e-02	0.2450	-0.001760	-0.028600	-1.72e-01	0.095900	-0.144000	9.77e-01	6.32e-01	3.98e-03	1.08e-01	1.61e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	4.33e-04	2.31e-03	0.2450	0.089200	-0.012100	-2.32e-02	-0.004280	-0.227000	1.76e-01	8.54e-01	7.26e-01	9.48e-01	5.91e-04
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	45	1.03e-01	1.94e-01	0.2440	0.057000	0.128000	1.95e-01	-0.041300	0.020400	5.08e-01	1.39e-01	2.35e-02	6.32e-01	8.13e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	64	5.30e-02	1.20e-01	0.2440	0.113000	-0.056100	4.33e-02	0.203000	-0.025800	1.19e-01	4.38e-01	5.49e-01	4.97e-03	7.22e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	8.13e-01	8.55e-01	0.2440	-0.101000	-0.073700	-8.67e-02	0.001010	-0.191000	4.57e-01	5.88e-01	5.24e-01	9.94e-01	1.61e-01
NETRIN 1 SIGNALING	48	8.92e-03	2.97e-02	0.2430	-0.143000	-0.095300	1.12e-01	-0.013500	0.130000	8.58e-02	2.54e-01	1.79e-01	8.71e-01	1.20e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	2.02e-01	3.15e-01	0.2430	0.009850	0.192000	9.13e-02	0.077100	0.088900	9.13e-01	3.35e-02	3.12e-01	3.93e-01	3.25e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	31	1.78e-01	2.89e-01	0.2430	0.138000	0.125000	1.24e-01	-0.065200	-0.069500	1.84e-01	2.29e-01	2.31e-01	5.30e-01	5.03e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	5.09e-07	5.10e-06	0.2430	-0.177000	0.049500	8.88e-02	0.129000	-0.024200	5.81e-03	4.42e-01	1.67e-01	4.47e-02	7.07e-01
BIOLOGICAL OXIDATIONS	120	2.41e-05	1.69e-04	0.2430	0.066200	0.103000	-2.03e-02	0.116000	-0.174000	2.11e-01	5.07e-02	7.01e-01	2.89e-02	1.03e-03
DAP12 SIGNALING	24	8.13e-01	8.55e-01	0.2420	-0.157000	-0.141000	-8.48e-02	-0.043000	-0.072100	1.84e-01	2.31e-01	4.72e-01	7.15e-01	5.41e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	61	5.51e-03	1.95e-02	0.2420	0.091500	0.131000	5.94e-02	-0.157000	-0.070600	2.16e-01	7.68e-02	4.23e-01	3.43e-02	3.41e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	3.72e-02	9.10e-02	0.2410	0.115000	0.186000	3.43e-02	-0.063200	-0.071300	1.74e-01	2.77e-02	6.84e-01	4.53e-01	3.98e-01
INTRA GOLGI TRAFFIC	43	3.94e-02	9.40e-02	0.2410	-0.021700	-0.128000	9.09e-02	0.181000	0.008730	8.06e-01	1.47e-01	3.03e-01	4.02e-02	9.21e-01
PLASMA LIPOPROTEIN REMODELING	13	5.16e-01	6.16e-01	0.2400	0.009390	-0.120000	2.00e-01	-0.043700	0.035100	9.53e-01	4.54e-01	2.11e-01	7.85e-01	8.27e-01
TNF SIGNALING	43	5.07e-01	6.08e-01	0.2400	0.118000	0.077500	9.59e-02	0.116000	0.123000	1.82e-01	3.79e-01	2.77e-01	1.87e-01	1.65e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	36	1.58e-01	2.67e-01	0.2400	-0.010800	0.040800	-1.09e-01	-0.043000	-0.205000	9.11e-01	6.72e-01	2.57e-01	6.55e-01	3.37e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	4.72e-01	5.76e-01	0.2400	-0.114000	-0.081600	-5.78e-03	0.194000	-0.005320	4.02e-01	5.49e-01	9.66e-01	1.54e-01	9.69e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	57	9.31e-02	1.80e-01	0.2380	0.071900	0.199000	3.87e-02	0.101000	0.015700	3.48e-01	9.48e-03	6.14e-01	1.87e-01	8.37e-01
MITOTIC PROPHASE	91	3.66e-02	8.99e-02	0.2380	-0.081000	-0.100000	-5.63e-02	0.086400	-0.171000	1.82e-01	9.83e-02	3.53e-01	1.55e-01	4.87e-03
OTHER INTERLEUKIN SIGNALING	19	8.27e-01	8.68e-01	0.2380	0.112000	0.061200	8.42e-02	0.145000	0.110000	3.99e-01	6.44e-01	5.25e-01	2.74e-01	4.07e-01
AMINO ACIDS REGULATE MTORC1	51	8.77e-02	1.72e-01	0.2370	0.064000	-0.004650	8.06e-03	0.160000	-0.163000	4.29e-01	9.54e-01	9.21e-01	4.84e-02	4.40e-02
RHOJ GTPASE CYCLE	53	6.40e-03	2.20e-02	0.2370	-0.200000	0.017300	-6.81e-02	0.067800	0.081100	1.20e-02	8.27e-01	3.91e-01	3.93e-01	3.08e-01
APOPTOTIC EXECUTION PHASE	43	5.00e-01	6.00e-01	0.2370	-0.126000	-0.060800	-1.64e-01	0.042200	-0.087100	1.53e-01	4.91e-01	6.22e-02	6.33e-01	3.23e-01
RNA POLYMERASE I TRANSCRIPTION	66	9.97e-04	4.50e-03	0.2360	0.106000	0.125000	2.62e-02	-0.080100	-0.148000	1.36e-01	8.01e-02	7.13e-01	2.61e-01	3.82e-02
IRAK4 DEFICIENCY TLR2 4	12	8.40e-01	8.76e-01	0.2360	-0.104000	0.023100	-1.96e-01	-0.000346	-0.075900	5.32e-01	8.90e-01	2.39e-01	9.98e-01	6.49e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	5.37e-01	6.33e-01	0.2360	0.151000	0.175000	1.99e-02	-0.003440	-0.042400	2.42e-01	1.76e-01	8.77e-01	9.79e-01	7.43e-01
SIGNALING BY NOTCH2	32	6.14e-02	1.34e-01	0.2350	-0.055900	-0.055400	1.95e-01	0.064800	0.083200	5.84e-01	5.88e-01	5.62e-02	5.26e-01	4.15e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	233	1.48e-13	4.88e-12	0.2350	-0.112000	-0.088200	3.21e-02	0.166000	0.080000	3.36e-03	2.07e-02	3.99e-01	1.29e-05	3.57e-02
ION HOMEOSTASIS	47	2.80e-02	7.36e-02	0.2350	-0.172000	-0.062700	8.06e-02	-0.063700	0.104000	4.10e-02	4.58e-01	3.39e-01	4.50e-01	2.16e-01
RHOU GTPASE CYCLE	33	7.97e-02	1.60e-01	0.2340	-0.134000	-0.111000	-2.60e-03	0.049100	0.149000	1.83e-01	2.70e-01	9.79e-01	6.26e-01	1.38e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	7.49e-01	8.04e-01	0.2340	-0.170000	0.047500	1.97e-02	-0.096500	0.119000	3.08e-01	7.76e-01	9.06e-01	5.63e-01	4.76e-01
FRS MEDIATED FGFR3 SIGNALING	14	5.55e-01	6.47e-01	0.2340	-0.029000	0.146000	-1.48e-01	0.100000	-0.027900	8.51e-01	3.45e-01	3.38e-01	5.16e-01	8.56e-01
BASE EXCISION REPAIR	55	4.28e-03	1.57e-02	0.2340	0.113000	0.097400	1.93e-02	-0.053800	-0.170000	1.46e-01	2.12e-01	8.05e-01	4.90e-01	2.88e-02
ION TRANSPORT BY P TYPE ATPASES	47	6.52e-02	1.39e-01	0.2330	-0.079700	-0.022900	4.56e-02	-0.065000	0.203000	3.45e-01	7.86e-01	5.88e-01	4.41e-01	1.59e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	26	4.53e-01	5.65e-01	0.2330	0.041800	-0.011400	8.59e-02	0.189000	0.095800	7.12e-01	9.20e-01	4.48e-01	9.48e-02	3.98e-01
FLT3 SIGNALING IN DISEASE	27	8.83e-02	1.73e-01	0.2330	0.022200	-0.005920	-9.12e-02	-0.103000	0.186000	8.42e-01	9.58e-01	4.12e-01	3.52e-01	9.40e-02
APOPTOSIS	159	1.59e-04	9.25e-04	0.2330	0.042800	-0.005420	-9.40e-02	0.110000	-0.177000	3.53e-01	9.06e-01	4.11e-02	1.72e-02	1.16e-04
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	12	8.60e-01	8.91e-01	0.2330	-0.120000	-0.101000	2.56e-02	-0.163000	0.046900	4.71e-01	5.46e-01	8.78e-01	3.27e-01	7.78e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	5.37e-02	1.21e-01	0.2320	0.053100	-0.001790	2.12e-02	0.064100	0.216000	5.47e-01	9.84e-01	8.10e-01	4.67e-01	1.43e-02
L1CAM INTERACTIONS	107	7.57e-04	3.63e-03	0.2320	-0.011500	0.047300	1.23e-01	0.134000	0.136000	8.38e-01	3.99e-01	2.83e-02	1.65e-02	1.55e-02
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	22	3.00e-01	4.22e-01	0.2320	-0.116000	-0.157000	2.61e-02	0.034400	0.118000	3.46e-01	2.03e-01	8.32e-01	7.80e-01	3.38e-01
SIGNALING BY NTRK2 TRKB	24	3.46e-01	4.67e-01	0.2320	-0.168000	-0.119000	-4.98e-02	0.063500	0.068300	1.54e-01	3.14e-01	6.73e-01	5.90e-01	5.62e-01
FRS MEDIATED FGFR1 SIGNALING	16	6.92e-01	7.56e-01	0.2310	-0.019600	0.052200	-1.24e-01	0.011400	-0.187000	8.92e-01	7.18e-01	3.92e-01	9.37e-01	1.95e-01
ACYL CHAIN REMODELLING OF PG	10	8.78e-01	9.04e-01	0.2310	-0.036400	-0.117000	-8.03e-02	0.179000	-0.008320	8.42e-01	5.22e-01	6.60e-01	3.28e-01	9.64e-01
MYOGENESIS	25	4.55e-01	5.66e-01	0.2310	-0.181000	-0.051400	-1.11e-03	-0.102000	0.085900	1.17e-01	6.56e-01	9.92e-01	3.77e-01	4.57e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	282	8.37e-06	6.67e-05	0.2300	-0.012400	-0.148000	-7.51e-02	0.092700	-0.130000	7.20e-01	2.06e-05	3.05e-02	7.51e-03	1.79e-04
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	4.98e-01	5.99e-01	0.2300	0.064700	-0.110000	2.08e-02	0.172000	-0.081600	5.68e-01	3.32e-01	8.54e-01	1.29e-01	4.72e-01
NEGATIVE REGULATION OF MAPK PATHWAY	41	8.24e-02	1.64e-01	0.2300	0.034600	-0.055600	8.96e-02	0.159000	-0.124000	7.02e-01	5.38e-01	3.21e-01	7.84e-02	1.70e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	4.61e-01	5.70e-01	0.2300	0.034700	0.053300	1.95e-01	0.093500	0.045500	7.74e-01	6.58e-01	1.06e-01	4.38e-01	7.06e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	31	2.19e-01	3.35e-01	0.2300	-0.210000	-0.053000	1.93e-02	-0.065900	0.032500	4.28e-02	6.10e-01	8.52e-01	5.26e-01	7.54e-01
MTOR SIGNALLING	40	3.76e-01	4.97e-01	0.2290	0.011500	-0.025200	-5.78e-02	0.177000	-0.131000	9.00e-01	7.82e-01	5.27e-01	5.29e-02	1.51e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	1.57e-01	2.66e-01	0.2290	0.055100	-0.123000	2.25e-02	0.132000	-0.127000	5.27e-01	1.57e-01	7.96e-01	1.29e-01	1.44e-01
BASE EXCISION REPAIR AP SITE FORMATION	28	1.45e-01	2.49e-01	0.2290	0.140000	0.083300	2.57e-02	-0.072300	-0.142000	2.01e-01	4.46e-01	8.14e-01	5.08e-01	1.95e-01
RHOV GTPASE CYCLE	32	7.54e-02	1.54e-01	0.2290	-0.100000	-0.075900	-5.68e-02	0.103000	0.151000	3.27e-01	4.57e-01	5.78e-01	3.13e-01	1.40e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	19	3.64e-01	4.84e-01	0.2280	-0.106000	0.174000	-9.65e-02	0.000993	0.038600	4.24e-01	1.90e-01	4.66e-01	9.94e-01	7.71e-01
INTERLEUKIN 1 FAMILY SIGNALING	119	2.31e-04	1.30e-03	0.2280	0.129000	0.095400	-5.98e-02	0.106000	-0.108000	1.55e-02	7.24e-02	2.60e-01	4.58e-02	4.19e-02
DEFECTS IN COBALAMIN B12 METABOLISM	12	8.75e-01	9.01e-01	0.2280	0.109000	0.027800	-2.59e-02	0.165000	-0.107000	5.12e-01	8.67e-01	8.76e-01	3.22e-01	5.21e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	22	6.19e-01	7.02e-01	0.2280	-0.034500	0.018900	-8.23e-02	0.193000	-0.079600	7.79e-01	8.78e-01	5.04e-01	1.18e-01	5.18e-01
RESOLUTION OF SISTER CHROMATID COHESION	98	7.13e-03	2.42e-02	0.2270	0.038200	0.048800	-1.04e-01	0.157000	-0.111000	5.14e-01	4.04e-01	7.64e-02	7.25e-03	5.81e-02
GLUCOSE METABOLISM	79	6.21e-02	1.35e-01	0.2270	0.136000	0.018200	1.18e-01	0.135000	-0.020000	3.66e-02	7.80e-01	6.97e-02	3.76e-02	7.59e-01
RND2 GTPASE CYCLE	38	1.61e-01	2.69e-01	0.2270	-0.058800	0.005140	9.33e-02	0.008470	0.198000	5.31e-01	9.56e-01	3.20e-01	9.28e-01	3.47e-02
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	31	1.84e-02	5.28e-02	0.2270	-0.039700	-0.036000	1.85e-01	0.047300	-0.109000	7.02e-01	7.29e-01	7.41e-02	6.49e-01	2.93e-01
TRP CHANNELS	18	5.17e-01	6.17e-01	0.2270	-0.036600	-0.054400	1.82e-01	-0.042200	0.111000	7.88e-01	6.89e-01	1.82e-01	7.57e-01	4.16e-01
GABA B RECEPTOR ACTIVATION	39	1.07e-01	1.98e-01	0.2260	-0.092400	-0.053500	-8.07e-03	0.199000	0.019100	3.18e-01	5.63e-01	9.31e-01	3.20e-02	8.37e-01
ENDOGENOUS STEROLS	20	5.94e-01	6.79e-01	0.2260	-0.008740	0.184000	-1.33e-02	-0.105000	0.078400	9.46e-01	1.55e-01	9.18e-01	4.16e-01	5.44e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	7.28e-01	7.87e-01	0.2260	0.095600	0.146000	1.13e-01	0.069400	-0.054900	5.08e-01	3.14e-01	4.34e-01	6.31e-01	7.04e-01
STIMULI SENSING CHANNELS	71	9.32e-03	3.09e-02	0.2260	-0.088100	-0.043300	1.23e-01	-0.057600	0.151000	2.00e-01	5.29e-01	7.44e-02	4.01e-01	2.75e-02
MUSCLE CONTRACTION	153	6.11e-06	5.04e-05	0.2250	-0.138000	0.032800	9.44e-02	-0.119000	0.088300	3.32e-03	4.84e-01	4.42e-02	1.14e-02	5.97e-02
PLATELET HOMEOSTASIS	76	1.09e-01	2.00e-01	0.2250	-0.173000	-0.123000	-7.43e-02	-0.004940	-0.019500	9.21e-03	6.50e-02	2.63e-01	9.41e-01	7.69e-01
SIGNAL TRANSDUCTION BY L1	21	3.80e-01	4.98e-01	0.2250	-0.065700	0.013100	4.40e-02	0.195000	-0.078200	6.02e-01	9.17e-01	7.27e-01	1.21e-01	5.35e-01
PI METABOLISM	79	3.23e-05	2.19e-04	0.2250	-0.157000	-0.069200	1.04e-01	0.099200	0.025400	1.61e-02	2.88e-01	1.10e-01	1.28e-01	6.96e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	6.51e-01	7.27e-01	0.2250	-0.193000	-0.084900	-6.12e-02	-0.030400	-0.034700	8.79e-02	4.54e-01	5.89e-01	7.89e-01	7.59e-01
ERYTHROPOIETIN ACTIVATES RAS	13	7.16e-01	7.76e-01	0.2250	-0.131000	0.008690	-5.88e-02	0.170000	-0.030300	4.15e-01	9.57e-01	7.14e-01	2.89e-01	8.50e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	17	4.99e-01	5.99e-01	0.2240	-0.124000	0.092200	-1.59e-01	-0.007700	0.033100	3.78e-01	5.10e-01	2.57e-01	9.56e-01	8.13e-01
REGULATION OF INSULIN SECRETION	70	5.47e-03	1.94e-02	0.2240	-0.043800	-0.005970	1.98e-02	0.195000	0.098800	5.27e-01	9.31e-01	7.75e-01	4.91e-03	1.53e-01
DISEASES OF PROGRAMMED CELL DEATH	53	1.59e-02	4.76e-02	0.2220	0.095500	0.044900	1.05e-03	0.000335	-0.196000	2.30e-01	5.72e-01	9.89e-01	9.97e-01	1.37e-02
TELOMERE MAINTENANCE	77	7.17e-04	3.45e-03	0.2220	0.124000	0.006790	-2.96e-03	-0.041300	-0.179000	5.96e-02	9.18e-01	9.64e-01	5.32e-01	6.57e-03
GROWTH HORMONE RECEPTOR SIGNALING	20	5.52e-01	6.45e-01	0.2220	0.088500	-0.155000	1.27e-02	0.129000	-0.023900	4.93e-01	2.31e-01	9.22e-01	3.16e-01	8.53e-01
RHO GTPASES ACTIVATE PAKS	21	3.70e-01	4.90e-01	0.2220	-0.096800	0.153000	-3.59e-02	0.015000	0.122000	4.43e-01	2.25e-01	7.76e-01	9.05e-01	3.32e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	4.96e-01	5.98e-01	0.2220	-0.102000	0.017700	1.64e-01	-0.097000	0.045200	4.78e-01	9.03e-01	2.56e-01	5.02e-01	7.54e-01
DUAL INCISION IN GG NER	40	5.01e-02	1.15e-01	0.2210	0.017500	0.088700	-1.99e-02	-0.067500	-0.189000	8.49e-01	3.32e-01	8.27e-01	4.60e-01	3.83e-02
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	339	1.18e-05	9.13e-05	0.2210	-0.014200	-0.113000	-9.77e-02	0.084400	-0.139000	6.54e-01	3.75e-04	2.06e-03	7.73e-03	1.18e-05
SUMOYLATION OF SUMOYLATION PROTEINS	33	4.85e-01	5.87e-01	0.2200	-0.191000	-0.086700	-4.39e-02	-0.047100	-0.009220	5.72e-02	3.89e-01	6.63e-01	6.40e-01	9.27e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	5.18e-03	1.85e-02	0.2200	0.011800	0.217000	-2.62e-02	-0.010700	0.021000	8.56e-01	8.79e-04	6.87e-01	8.70e-01	7.47e-01
RHOQ GTPASE CYCLE	56	6.46e-03	2.21e-02	0.2200	-0.198000	0.058100	3.32e-02	-0.013600	0.064800	1.02e-02	4.53e-01	6.67e-01	8.60e-01	4.02e-01
VXPX CARGO TARGETING TO CILIUM	19	6.17e-01	7.00e-01	0.2190	0.109000	0.045200	-3.79e-02	0.166000	0.073000	4.11e-01	7.33e-01	7.75e-01	2.11e-01	5.82e-01
ACYL CHAIN REMODELLING OF PS	14	5.37e-01	6.33e-01	0.2190	0.043100	-0.151000	1.18e-01	-0.007890	-0.096400	7.80e-01	3.27e-01	4.44e-01	9.59e-01	5.32e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	36	3.41e-01	4.63e-01	0.2190	-0.048100	-0.037400	-6.27e-02	0.198000	-0.031200	6.17e-01	6.98e-01	5.15e-01	3.96e-02	7.46e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	47	1.65e-01	2.75e-01	0.2190	0.107000	-0.078300	1.09e-01	0.112000	0.077100	2.06e-01	3.53e-01	1.97e-01	1.86e-01	3.61e-01
RND3 GTPASE CYCLE	37	2.21e-01	3.35e-01	0.2180	-0.034500	0.006220	1.15e-01	0.053700	0.174000	7.16e-01	9.48e-01	2.27e-01	5.72e-01	6.64e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION	20	4.59e-01	5.70e-01	0.2180	0.032400	-0.070300	1.76e-01	0.096700	0.035600	8.02e-01	5.87e-01	1.72e-01	4.54e-01	7.83e-01
RESOLUTION OF ABASIC SITES AP SITES	37	8.31e-02	1.65e-01	0.2180	0.080100	0.123000	-1.51e-02	-0.097900	-0.128000	3.99e-01	1.97e-01	8.74e-01	3.03e-01	1.79e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	5.91e-01	6.75e-01	0.2180	-0.023000	-0.069000	-2.25e-02	0.169000	-0.115000	8.33e-01	5.28e-01	8.37e-01	1.22e-01	2.93e-01
SIGNALLING TO ERKS	31	3.78e-01	4.98e-01	0.2180	-0.020100	-0.143000	2.23e-02	0.150000	-0.058900	8.46e-01	1.68e-01	8.30e-01	1.49e-01	5.71e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	6.43e-01	7.20e-01	0.2170	-0.033900	0.159000	3.01e-02	-0.110000	-0.085700	8.32e-01	3.20e-01	8.51e-01	4.91e-01	5.93e-01
G PROTEIN ACTIVATION	21	5.17e-01	6.17e-01	0.2170	0.029900	-0.012000	-1.76e-01	0.107000	-0.058400	8.12e-01	9.24e-01	1.62e-01	3.95e-01	6.43e-01
TRANSCRIPTION OF THE HIV GENOME	67	1.75e-02	5.09e-02	0.2160	0.041600	0.044600	-9.59e-02	-0.018700	-0.183000	5.56e-01	5.28e-01	1.75e-01	7.92e-01	9.57e-03
SIGNALING BY INSULIN RECEPTOR	60	3.11e-01	4.33e-01	0.2160	-0.056000	-0.080600	-6.49e-02	0.091300	-0.157000	4.53e-01	2.80e-01	3.85e-01	2.22e-01	3.60e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING	23	6.71e-01	7.42e-01	0.2150	0.052100	0.088800	3.18e-02	0.182000	-0.039300	6.65e-01	4.61e-01	7.92e-01	1.30e-01	7.44e-01
PHOSPHOLIPID METABOLISM	183	3.98e-07	4.23e-06	0.2150	-0.014100	-0.011600	1.30e-01	0.152000	0.075700	7.42e-01	7.86e-01	2.37e-03	3.94e-04	7.80e-02
G ALPHA I SIGNALLING EVENTS	178	4.74e-07	4.85e-06	0.2150	-0.126000	-0.103000	-2.05e-03	0.140000	0.009300	3.86e-03	1.81e-02	9.62e-01	1.26e-03	8.31e-01
PLASMA LIPOPROTEIN ASSEMBLY	11	6.52e-01	7.27e-01	0.2150	0.081800	-0.169000	-9.87e-02	0.019300	0.025300	6.39e-01	3.30e-01	5.71e-01	9.12e-01	8.84e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	2.59e-01	3.80e-01	0.2140	-0.036500	-0.017700	-4.33e-02	0.206000	0.004270	6.97e-01	8.50e-01	6.44e-01	2.84e-02	9.64e-01
RHOF GTPASE CYCLE	40	1.90e-01	3.02e-01	0.2140	-0.116000	-0.037700	-5.55e-02	0.167000	-0.011900	2.05e-01	6.80e-01	5.44e-01	6.85e-02	8.96e-01
SIGNALING BY ERYTHROPOIETIN	24	2.78e-01	4.00e-01	0.2140	-0.180000	0.058000	6.37e-02	-0.063700	0.040400	1.26e-01	6.23e-01	5.89e-01	5.89e-01	7.32e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	3.96e-03	1.49e-02	0.2130	-0.173000	-0.034300	8.43e-02	0.083800	0.018900	3.14e-02	6.69e-01	2.93e-01	2.96e-01	8.14e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	1.07e-02	3.45e-02	0.2120	0.131000	0.102000	-7.41e-02	-0.024900	-0.107000	8.27e-02	1.77e-01	3.25e-01	7.41e-01	1.54e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	34	4.06e-01	5.20e-01	0.2120	0.061100	-0.019700	-1.52e-02	0.199000	0.033000	5.37e-01	8.42e-01	8.78e-01	4.49e-02	7.39e-01
NUCLEOTIDE EXCISION REPAIR	109	7.91e-04	3.73e-03	0.2120	0.040800	-0.033200	-2.15e-02	0.012400	-0.204000	4.62e-01	5.50e-01	6.98e-01	8.23e-01	2.44e-04
INTRINSIC PATHWAY FOR APOPTOSIS	50	3.40e-01	4.62e-01	0.2100	-0.059600	-0.083900	-3.93e-02	0.134000	-0.118000	4.66e-01	3.05e-01	6.31e-01	1.01e-01	1.48e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	1.98e-01	3.11e-01	0.2100	0.108000	0.156000	6.86e-02	-0.057900	0.007510	1.51e-01	3.85e-02	3.62e-01	4.42e-01	9.21e-01
GPVI MEDIATED ACTIVATION CASCADE	31	1.05e-01	1.96e-01	0.2090	-0.091900	0.051400	4.45e-02	0.107000	-0.138000	3.76e-01	6.21e-01	6.68e-01	3.02e-01	1.84e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	6.01e-02	1.32e-01	0.2080	0.066300	0.144000	2.70e-02	0.018500	0.132000	2.62e-01	1.52e-02	6.47e-01	7.55e-01	2.58e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS	49	1.83e-02	5.28e-02	0.2080	-0.079000	-0.139000	1.17e-01	0.055200	-0.025200	3.39e-01	9.16e-02	1.56e-01	5.04e-01	7.61e-01
REGULATION OF FZD BY UBIQUITINATION	19	5.43e-01	6.37e-01	0.2070	0.164000	-0.077300	-1.33e-02	0.097500	0.018900	2.15e-01	5.60e-01	9.20e-01	4.62e-01	8.87e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	21	7.86e-01	8.36e-01	0.2070	0.052800	0.014700	-6.48e-03	0.193000	-0.051200	6.76e-01	9.07e-01	9.59e-01	1.27e-01	6.85e-01
CHROMOSOME MAINTENANCE	100	9.55e-04	4.36e-03	0.2070	0.060400	0.020900	-6.49e-02	-0.046700	-0.180000	2.97e-01	7.18e-01	2.62e-01	4.20e-01	1.93e-03
IRS MEDIATED SIGNALLING	36	7.51e-01	8.06e-01	0.2060	-0.140000	-0.068100	-6.93e-02	-0.084600	-0.077500	1.46e-01	4.79e-01	4.72e-01	3.80e-01	4.21e-01
SIGNALING BY VEGF	101	1.76e-05	1.30e-04	0.2050	-0.167000	0.013200	3.91e-02	0.111000	-0.014100	3.76e-03	8.19e-01	4.98e-01	5.36e-02	8.07e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	2.52e-01	3.73e-01	0.2030	0.094700	0.071300	-4.20e-02	-0.083800	-0.136000	3.86e-01	5.14e-01	7.01e-01	4.43e-01	2.14e-01
ONCOGENE INDUCED SENESCENCE	32	5.67e-01	6.59e-01	0.2030	0.050500	-0.021300	1.29e-01	0.047000	0.139000	6.21e-01	8.35e-01	2.06e-01	6.45e-01	1.74e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	8.43e-01	8.78e-01	0.2030	0.124000	0.052200	-1.54e-02	0.045000	-0.144000	4.76e-01	7.64e-01	9.29e-01	7.96e-01	4.07e-01
AMYLOID FIBER FORMATION	55	1.09e-02	3.47e-02	0.2030	0.080100	-0.028600	9.61e-02	-0.031000	-0.154000	3.05e-01	7.13e-01	2.18e-01	6.91e-01	4.86e-02
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	7.74e-02	1.57e-01	0.2020	-0.024900	-0.073200	-2.55e-02	0.168000	-0.078600	6.89e-01	2.38e-01	6.81e-01	6.89e-03	2.06e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	7.90e-01	8.38e-01	0.2020	0.087900	0.045700	1.63e-01	0.054800	0.036200	4.66e-01	7.05e-01	1.75e-01	6.49e-01	7.64e-01
AQUAPORIN MEDIATED TRANSPORT	39	4.04e-01	5.18e-01	0.2010	-0.074100	-0.008610	-6.25e-02	0.161000	-0.072700	4.24e-01	9.26e-01	5.00e-01	8.29e-02	4.32e-01
PECAM1 INTERACTIONS	12	7.36e-01	7.95e-01	0.2000	-0.158000	0.019100	7.64e-02	-0.023100	0.091600	3.43e-01	9.09e-01	6.47e-01	8.90e-01	5.83e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	4.08e-01	5.20e-01	0.2000	-0.088800	-0.056000	-1.59e-01	0.060800	0.006240	3.71e-01	5.72e-01	1.09e-01	5.40e-01	9.50e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	593	4.19e-21	2.42e-19	0.2000	0.093700	0.091100	-3.62e-02	0.042000	-0.141000	1.06e-04	1.62e-04	1.34e-01	8.19e-02	5.60e-09
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	9.66e-01	9.74e-01	0.2000	0.078000	0.065000	7.63e-02	0.068800	0.138000	6.40e-01	6.97e-01	6.47e-01	6.80e-01	4.08e-01
CLATHRIN MEDIATED ENDOCYTOSIS	129	1.22e-03	5.37e-03	0.2000	-0.018500	-0.082300	4.08e-02	0.163000	-0.066400	7.17e-01	1.07e-01	4.24e-01	1.37e-03	1.93e-01
MITOTIC G2 G2 M PHASES	183	2.20e-05	1.56e-04	0.2000	0.108000	0.085700	-5.85e-02	0.084100	-0.102000	1.19e-02	4.59e-02	1.73e-01	5.02e-02	1.78e-02
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	62	6.90e-01	7.54e-01	0.1990	-0.090200	-0.093400	-1.05e-01	-0.033000	-0.103000	2.19e-01	2.03e-01	1.51e-01	6.53e-01	1.60e-01
DISEASES OF IMMUNE SYSTEM	23	7.67e-01	8.20e-01	0.1990	-0.014000	0.144000	5.08e-02	-0.106000	0.071000	9.08e-01	2.33e-01	6.73e-01	3.80e-01	5.56e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	6.27e-01	7.08e-01	0.1990	-0.087400	-0.064800	1.65e-01	-0.014900	-0.021400	6.16e-01	7.10e-01	3.44e-01	9.32e-01	9.02e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	89	6.47e-02	1.39e-01	0.1990	-0.025300	-0.107000	-7.84e-03	0.139000	-0.089800	6.80e-01	8.12e-02	8.98e-01	2.33e-02	1.44e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	106	4.78e-03	1.74e-02	0.1990	0.085400	-0.023500	-1.07e-01	0.043300	-0.135000	1.29e-01	6.76e-01	5.67e-02	4.42e-01	1.61e-02
DEADENYLATION DEPENDENT MRNA DECAY	55	5.73e-01	6.61e-01	0.1990	-0.079600	-0.042000	-1.14e-01	-0.062800	-0.120000	3.08e-01	5.91e-01	1.45e-01	4.21e-01	1.23e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	20	7.72e-01	8.23e-01	0.1980	0.051900	0.017400	-1.04e-01	0.128000	-0.095800	6.88e-01	8.93e-01	4.20e-01	3.23e-01	4.58e-01
ARACHIDONIC ACID METABOLISM	37	1.07e-01	1.98e-01	0.1980	0.024200	0.103000	2.15e-02	-0.042500	-0.160000	7.99e-01	2.77e-01	8.21e-01	6.54e-01	9.20e-02
POST TRANSLATIONAL PROTEIN MODIFICATION	1188	1.06e-23	7.21e-22	0.1980	0.011100	-0.084400	-1.52e-02	0.146000	-0.102000	5.26e-01	1.24e-06	3.82e-01	5.82e-17	4.70e-09
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	9.25e-01	9.41e-01	0.1970	0.067400	0.071500	2.59e-02	0.163000	-0.044100	6.74e-01	6.55e-01	8.72e-01	3.08e-01	7.83e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	25	5.50e-01	6.44e-01	0.1970	0.051700	0.033400	3.30e-02	0.119000	-0.140000	6.55e-01	7.73e-01	7.75e-01	3.03e-01	2.24e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	2.51e-01	3.72e-01	0.1960	-0.054500	-0.040400	-1.23e-02	0.177000	-0.049000	5.14e-01	6.28e-01	8.82e-01	3.39e-02	5.57e-01
DEATH RECEPTOR SIGNALLING	132	1.61e-03	6.92e-03	0.1960	-0.016200	0.042600	1.62e-01	0.027500	0.096500	7.48e-01	3.99e-01	1.30e-03	5.86e-01	5.58e-02
SIGNALING BY SCF KIT	41	2.65e-01	3.86e-01	0.1960	-0.080700	-0.134000	-6.91e-02	0.085300	0.042700	3.72e-01	1.37e-01	4.44e-01	3.45e-01	6.37e-01
SIGNALING BY PDGF	55	5.12e-01	6.13e-01	0.1950	0.036800	0.142000	8.96e-02	-0.057300	0.073000	6.37e-01	6.88e-02	2.51e-01	4.62e-01	3.49e-01
M PHASE	333	2.36e-07	2.55e-06	0.1950	0.039900	0.022100	-9.10e-02	0.096700	-0.135000	2.12e-01	4.89e-01	4.44e-03	2.49e-03	2.26e-05
SIGNALING BY NOTCH3	48	1.11e-01	2.04e-01	0.1950	-0.058900	0.007990	1.61e-01	-0.024500	0.089400	4.80e-01	9.24e-01	5.42e-02	7.69e-01	2.84e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	104	2.59e-02	6.88e-02	0.1940	0.052200	0.086700	-9.40e-03	0.145000	-0.079800	3.58e-01	1.27e-01	8.69e-01	1.06e-02	1.60e-01
EGFR DOWNREGULATION	27	3.95e-01	5.09e-01	0.1940	-0.066800	-0.081700	5.71e-02	0.149000	-0.030600	5.48e-01	4.63e-01	6.07e-01	1.79e-01	7.83e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	75	1.78e-01	2.89e-01	0.1940	-0.018000	-0.017900	-5.38e-02	0.166000	-0.080000	7.88e-01	7.89e-01	4.21e-01	1.28e-02	2.31e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	3.74e-02	9.13e-02	0.1940	0.021900	-0.070700	-1.97e-03	0.106000	0.144000	7.77e-01	3.61e-01	9.80e-01	1.70e-01	6.18e-02
RHO GTPASES ACTIVATE KTN1	11	8.88e-01	9.11e-01	0.1930	-0.016300	0.068900	-7.52e-02	0.027200	-0.161000	9.25e-01	6.92e-01	6.66e-01	8.76e-01	3.55e-01
HOMOLOGY DIRECTED REPAIR	105	4.48e-02	1.04e-01	0.1920	-0.052300	-0.061700	-3.27e-02	-0.136000	-0.104000	3.55e-01	2.75e-01	5.63e-01	1.59e-02	6.71e-02
MEIOSIS	61	5.82e-01	6.68e-01	0.1920	-0.102000	-0.034200	-1.11e-01	-0.069900	-0.090200	1.69e-01	6.44e-01	1.34e-01	3.45e-01	2.23e-01
SIGNALING BY NTRKS	127	1.44e-04	8.57e-04	0.1920	-0.037900	-0.098500	7.96e-02	0.119000	-0.070900	4.61e-01	5.54e-02	1.22e-01	2.05e-02	1.68e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	5.72e-01	6.61e-01	0.1910	-0.154000	-0.084300	-1.37e-02	-0.073600	-0.011200	1.04e-01	3.75e-01	8.86e-01	4.39e-01	9.06e-01
CELL JUNCTION ORGANIZATION	71	3.93e-02	9.40e-02	0.1910	-0.117000	-0.139000	2.23e-02	0.055500	0.003630	8.93e-02	4.26e-02	7.46e-01	4.19e-01	9.58e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	8.75e-01	9.01e-01	0.1910	0.145000	-0.082400	5.27e-03	0.092100	-0.000823	4.04e-01	6.36e-01	9.76e-01	5.97e-01	9.96e-01
NUCLEOBASE CATABOLISM	31	5.31e-01	6.28e-01	0.1910	0.042400	-0.030600	-8.42e-02	0.163000	-0.011100	6.83e-01	7.68e-01	4.17e-01	1.17e-01	9.15e-01
SIGNALING BY MET	73	2.93e-01	4.16e-01	0.1910	0.028300	0.144000	5.37e-02	0.021800	0.107000	6.76e-01	3.37e-02	4.28e-01	7.48e-01	1.14e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	8.64e-01	8.93e-01	0.1900	0.127000	0.103000	9.12e-02	0.012500	0.031200	2.29e-01	3.28e-01	3.87e-01	9.06e-01	7.67e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	5.75e-01	6.62e-01	0.1900	-0.165000	-0.060000	-7.72e-05	-0.073200	-0.003970	1.13e-01	5.63e-01	9.99e-01	4.81e-01	9.70e-01
HCMV EARLY EVENTS	78	2.26e-01	3.41e-01	0.1900	0.086200	0.098000	1.33e-01	0.035600	0.009120	1.88e-01	1.35e-01	4.25e-02	5.87e-01	8.89e-01
SIGNALING BY NOTCH1	75	1.63e-01	2.71e-01	0.1890	-0.004170	0.035200	1.34e-01	0.014100	0.128000	9.50e-01	5.98e-01	4.43e-02	8.33e-01	5.56e-02
HCMV INFECTION	101	1.27e-02	3.94e-02	0.1890	0.093600	0.059000	1.05e-01	0.079600	-0.079400	1.04e-01	3.06e-01	6.96e-02	1.67e-01	1.68e-01
HIV TRANSCRIPTION ELONGATION	42	1.18e-01	2.13e-01	0.1890	0.103000	0.051300	4.28e-02	-0.045100	-0.137000	2.48e-01	5.65e-01	6.31e-01	6.14e-01	1.26e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	92	1.72e-02	5.05e-02	0.1890	0.128000	0.049900	-3.68e-02	0.063600	-0.106000	3.33e-02	4.08e-01	5.43e-01	2.92e-01	7.79e-02
CELL CYCLE MITOTIC	466	8.05e-09	1.11e-07	0.1890	0.021200	0.005570	-8.66e-02	0.088300	-0.141000	4.35e-01	8.37e-01	1.43e-03	1.14e-03	1.96e-07
TELOMERE EXTENSION BY TELOMERASE	22	8.29e-01	8.69e-01	0.1890	0.117000	0.107000	2.80e-03	0.089800	0.048900	3.40e-01	3.85e-01	9.82e-01	4.66e-01	6.91e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	9.46e-01	9.59e-01	0.1890	0.146000	0.039700	6.19e-02	0.085100	0.043200	3.14e-01	7.83e-01	6.68e-01	5.55e-01	7.65e-01
GPCR LIGAND BINDING	226	8.23e-06	6.65e-05	0.1880	0.006020	-0.082600	3.74e-02	0.163000	0.023800	8.76e-01	3.28e-02	3.34e-01	2.47e-05	5.38e-01
P38MAPK EVENTS	12	8.38e-01	8.75e-01	0.1880	0.075200	0.018900	1.58e-01	0.047100	-0.046800	6.52e-01	9.10e-01	3.44e-01	7.78e-01	7.79e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	7.94e-01	8.39e-01	0.1880	-0.068100	-0.136000	1.44e-02	0.109000	-0.004100	6.37e-01	3.46e-01	9.20e-01	4.51e-01	9.77e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	7.69e-01	8.22e-01	0.1870	0.126000	0.042000	8.95e-02	0.054900	-0.078800	3.41e-01	7.51e-01	4.99e-01	6.79e-01	5.52e-01
ADAPTIVE IMMUNE SYSTEM	584	7.71e-08	9.09e-07	0.1870	-0.012600	-0.079400	-6.28e-02	0.119000	-0.101000	6.04e-01	1.11e-03	9.91e-03	9.49e-07	3.16e-05
MEMBRANE TRAFFICKING	571	4.99e-12	1.11e-10	0.1870	0.023900	-0.045700	3.07e-02	0.170000	-0.048200	3.30e-01	6.34e-02	2.12e-01	4.72e-12	5.00e-02
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	40	6.84e-01	7.51e-01	0.1860	-0.141000	-0.038600	-4.60e-02	-0.100000	-0.036400	1.24e-01	6.73e-01	6.15e-01	2.73e-01	6.91e-01
SLC TRANSPORTER DISORDERS	67	1.94e-01	3.06e-01	0.1860	-0.147000	-0.111000	-1.89e-02	-0.021400	0.008170	3.81e-02	1.17e-01	7.89e-01	7.62e-01	9.08e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	4.47e-01	5.60e-01	0.1850	-0.129000	-0.102000	-4.94e-02	-0.021300	-0.066900	5.83e-02	1.36e-01	4.69e-01	7.55e-01	3.26e-01
CELLULAR RESPONSE TO HEAT STRESS	94	7.74e-02	1.57e-01	0.1850	0.017700	0.028100	-1.92e-03	0.173000	-0.059100	7.67e-01	6.38e-01	9.74e-01	3.86e-03	3.22e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	64	1.04e-01	1.95e-01	0.1850	-0.001550	0.013900	1.06e-01	-0.151000	-0.004110	9.83e-01	8.48e-01	1.42e-01	3.74e-02	9.55e-01
HIV LIFE CYCLE	142	5.14e-03	1.85e-02	0.1850	0.009850	0.022100	-8.00e-02	0.034000	-0.161000	8.40e-01	6.50e-01	1.00e-01	4.85e-01	9.29e-04
RAC2 GTPASE CYCLE	86	3.23e-03	1.26e-02	0.1850	-0.152000	0.039700	-2.44e-02	0.076500	0.054800	1.51e-02	5.25e-01	6.95e-01	2.20e-01	3.80e-01
FLT3 SIGNALING	36	3.63e-01	4.84e-01	0.1850	-0.072500	-0.107000	-2.67e-02	-0.063300	0.113000	4.52e-01	2.68e-01	7.82e-01	5.11e-01	2.43e-01
INSULIN RECEPTOR SIGNALLING CASCADE	41	7.63e-01	8.18e-01	0.1840	-0.140000	-0.076400	-6.14e-02	-0.033400	-0.058400	1.20e-01	3.97e-01	4.97e-01	7.11e-01	5.18e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	8.96e-01	9.17e-01	0.1830	-0.109000	-0.069900	-7.58e-02	-0.021100	-0.103000	2.88e-01	4.94e-01	4.58e-01	8.36e-01	3.11e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	8.19e-01	8.61e-01	0.1830	0.014800	-0.121000	-1.01e-01	0.024900	-0.089200	9.00e-01	3.06e-01	3.92e-01	8.33e-01	4.49e-01
NICOTINATE METABOLISM	23	3.31e-01	4.53e-01	0.1830	-0.055000	0.090000	4.52e-02	0.021400	-0.141000	6.48e-01	4.55e-01	7.07e-01	8.59e-01	2.42e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	102	8.78e-03	2.93e-02	0.1830	0.042400	0.064600	2.07e-02	-0.156000	-0.050500	4.59e-01	2.60e-01	7.19e-01	6.37e-03	3.79e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	4.49e-01	5.62e-01	0.1820	-0.035500	0.140000	-8.08e-02	-0.052400	-0.055100	7.45e-01	1.99e-01	4.59e-01	6.31e-01	6.14e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	151	6.18e-04	3.04e-03	0.1820	-0.023200	-0.090800	2.86e-02	0.151000	0.029100	6.22e-01	5.45e-02	5.44e-01	1.40e-03	5.37e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	73	1.35e-01	2.37e-01	0.1820	-0.046100	0.035400	1.26e-01	-0.065700	0.097600	4.96e-01	6.01e-01	6.27e-02	3.32e-01	1.50e-01
IRAK1 RECRUITS IKK COMPLEX	14	9.78e-01	9.83e-01	0.1810	0.083400	0.122000	5.41e-02	-0.008030	0.089800	5.89e-01	4.30e-01	7.26e-01	9.59e-01	5.61e-01
ESTROGEN DEPENDENT GENE EXPRESSION	99	6.50e-02	1.39e-01	0.1810	-0.062800	-0.018400	-4.59e-03	-0.157000	-0.061300	2.81e-01	7.52e-01	9.37e-01	6.91e-03	2.92e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	17	6.53e-01	7.27e-01	0.1810	0.054500	-0.036600	1.57e-01	0.037900	-0.047900	6.97e-01	7.94e-01	2.62e-01	7.87e-01	7.32e-01
SIGNALING BY TGFB FAMILY MEMBERS	95	3.90e-01	5.03e-01	0.1800	-0.112000	-0.091300	-8.92e-02	0.030500	-0.051100	6.04e-02	1.24e-01	1.33e-01	6.07e-01	3.90e-01
SIGNALING BY WNT IN CANCER	30	4.79e-01	5.82e-01	0.1790	-0.049900	-0.152000	3.25e-02	0.072600	0.018100	6.36e-01	1.51e-01	7.58e-01	4.92e-01	8.64e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	7.11e-01	7.72e-01	0.1790	-0.133000	-0.096700	-5.45e-02	0.032000	-0.029600	1.66e-01	3.16e-01	5.72e-01	7.40e-01	7.59e-01
HCMV LATE EVENTS	63	1.59e-02	4.75e-02	0.1790	-0.013400	-0.053200	7.80e-02	-0.030600	-0.148000	8.54e-01	4.65e-01	2.84e-01	6.75e-01	4.25e-02
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	9.23e-01	9.40e-01	0.1780	-0.103000	-0.098800	4.41e-03	0.039700	-0.098700	5.38e-01	5.54e-01	9.79e-01	8.12e-01	5.54e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	89	1.72e-02	5.05e-02	0.1770	-0.136000	-0.049000	5.91e-03	0.074000	-0.071000	2.71e-02	4.25e-01	9.23e-01	2.28e-01	2.47e-01
INNATE IMMUNE SYSTEM	757	3.93e-13	1.14e-11	0.1770	0.016900	0.014300	-4.27e-02	0.119000	-0.122000	4.33e-01	5.07e-01	4.69e-02	3.48e-08	1.29e-08
SUMOYLATION OF TRANSCRIPTION FACTORS	16	9.59e-01	9.70e-01	0.1770	-0.049200	-0.058500	-6.13e-02	0.041400	-0.141000	7.34e-01	6.86e-01	6.71e-01	7.74e-01	3.29e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	2.53e-01	3.74e-01	0.1770	0.101000	0.045900	1.69e-02	-0.133000	-0.028800	2.53e-01	6.03e-01	8.48e-01	1.31e-01	7.44e-01
REPRODUCTION	73	3.02e-01	4.24e-01	0.1760	-0.100000	0.023700	-9.66e-02	-0.096900	-0.042500	1.40e-01	7.26e-01	1.54e-01	1.53e-01	5.30e-01
SIGNALING BY ERBB4	56	2.51e-01	3.73e-01	0.1760	-0.088100	-0.027200	-1.14e-01	0.097000	0.002570	2.54e-01	7.25e-01	1.40e-01	2.09e-01	9.74e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	8.58e-01	8.89e-01	0.1750	-0.061200	0.027300	9.69e-02	0.057200	0.116000	7.03e-01	8.65e-01	5.45e-01	7.21e-01	4.68e-01
VESICLE MEDIATED TRANSPORT	599	1.05e-10	1.89e-09	0.1750	0.030900	-0.032700	3.29e-02	0.161000	-0.040900	1.99e-01	1.74e-01	1.71e-01	2.35e-11	8.91e-02
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	5.71e-01	6.61e-01	0.1740	0.081300	0.114000	7.43e-02	0.044400	0.058100	1.96e-01	7.02e-02	2.37e-01	4.79e-01	3.55e-01
PTEN REGULATION	132	1.34e-02	4.11e-02	0.1740	0.105000	0.074600	-2.09e-02	0.082100	-0.080800	3.70e-02	1.39e-01	6.79e-01	1.04e-01	1.09e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	60	8.86e-02	1.73e-01	0.1740	-0.131000	-0.021400	-3.69e-02	0.097400	0.042300	7.97e-02	7.74e-01	6.22e-01	1.92e-01	5.71e-01
EXTENSION OF TELOMERES	49	1.79e-01	2.90e-01	0.1740	0.105000	0.043300	-4.80e-02	0.002020	-0.122000	2.03e-01	6.00e-01	5.61e-01	9.81e-01	1.39e-01
G ALPHA S SIGNALLING EVENTS	94	6.70e-03	2.28e-02	0.1730	-0.055400	-0.049000	1.18e-01	0.055800	0.086300	3.54e-01	4.12e-01	4.76e-02	3.50e-01	1.48e-01
RAC3 GTPASE CYCLE	88	1.33e-02	4.11e-02	0.1730	-0.149000	-0.024600	-2.18e-02	0.059000	0.057200	1.59e-02	6.91e-01	7.24e-01	3.39e-01	3.54e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	8.88e-01	9.11e-01	0.1730	0.046800	-0.006430	-3.99e-02	0.158000	-0.033900	7.17e-01	9.60e-01	7.57e-01	2.21e-01	7.93e-01
RHO GTPASES ACTIVATE FORMINS	116	6.83e-02	1.44e-01	0.1730	0.030200	0.029400	-2.66e-02	0.137000	-0.092700	5.75e-01	5.85e-01	6.21e-01	1.08e-02	8.48e-02
NONHOMOLOGOUS END JOINING NHEJ	42	8.62e-01	8.92e-01	0.1730	-0.072800	-0.069700	-7.67e-02	-0.027000	-0.114000	4.14e-01	4.34e-01	3.90e-01	7.62e-01	2.01e-01
SIGNALING BY CSF3 G CSF	29	7.05e-01	7.68e-01	0.1720	0.015800	-0.116000	-9.74e-02	0.071300	-0.037800	8.83e-01	2.80e-01	3.64e-01	5.07e-01	7.25e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	35	3.17e-01	4.38e-01	0.1720	-0.018800	0.005330	1.07e-02	-0.041600	-0.166000	8.47e-01	9.57e-01	9.13e-01	6.71e-01	9.01e-02
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	174	1.02e-03	4.57e-03	0.1720	0.092800	0.042400	-1.29e-02	0.066000	-0.121000	3.49e-02	3.35e-01	7.69e-01	1.34e-01	5.93e-03
REGULATION OF LIPID METABOLISM BY PPARALPHA	105	3.03e-02	7.75e-02	0.1720	-0.074100	-0.035700	8.27e-02	-0.066300	0.107000	1.90e-01	5.28e-01	1.43e-01	2.41e-01	5.73e-02
BETA CATENIN INDEPENDENT WNT SIGNALING	137	1.89e-02	5.38e-02	0.1720	0.085500	0.009470	-5.31e-02	0.096200	-0.100000	8.45e-02	8.48e-01	2.84e-01	5.22e-02	4.32e-02
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	26	4.72e-01	5.76e-01	0.1720	-0.099800	-0.070900	5.09e-02	0.105000	0.027600	3.79e-01	5.31e-01	6.54e-01	3.53e-01	8.08e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	26	6.86e-01	7.52e-01	0.1710	0.017000	0.035000	-1.73e-02	0.080200	-0.145000	8.81e-01	7.57e-01	8.79e-01	4.79e-01	2.01e-01
SIGNALING BY GPCR	438	8.99e-15	3.71e-13	0.1710	-0.075200	-0.058400	7.71e-02	0.099500	0.065400	7.20e-03	3.69e-02	5.83e-03	3.76e-04	1.94e-02
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	6.61e-01	7.34e-01	0.1710	0.003330	0.087900	4.46e-02	-0.002890	0.139000	9.71e-01	3.30e-01	6.21e-01	9.75e-01	1.23e-01
SIGNALING BY ACTIVIN	11	9.22e-01	9.40e-01	0.1710	-0.056800	-0.131000	-7.48e-02	0.017900	0.052200	7.44e-01	4.51e-01	6.67e-01	9.18e-01	7.64e-01
ACYL CHAIN REMODELLING OF PC	16	7.98e-01	8.42e-01	0.1690	-0.043600	0.008620	2.11e-02	0.111000	0.117000	7.63e-01	9.52e-01	8.84e-01	4.43e-01	4.17e-01
INTERLEUKIN 17 SIGNALING	66	1.91e-01	3.04e-01	0.1680	-0.061300	-0.097100	1.87e-02	0.083700	-0.087700	3.90e-01	1.73e-01	7.93e-01	2.40e-01	2.18e-01
PEPTIDE LIGAND BINDING RECEPTORS	86	1.54e-01	2.62e-01	0.1680	0.081400	-0.034900	-1.61e-02	0.141000	0.005760	1.92e-01	5.76e-01	7.97e-01	2.34e-02	9.27e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	1.73e-01	2.84e-01	0.1670	0.097900	0.111000	1.33e-03	-0.034600	-0.069400	2.01e-01	1.46e-01	9.86e-01	6.51e-01	3.65e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	176	1.78e-05	1.30e-04	0.1670	-0.069900	-0.037200	1.10e-01	0.056500	0.079800	1.10e-01	3.96e-01	1.18e-02	1.96e-01	6.81e-02
GENERATION OF SECOND MESSENGER MOLECULES	19	8.58e-01	8.89e-01	0.1670	-0.077600	0.052400	-7.33e-02	-0.060300	-0.101000	5.58e-01	6.93e-01	5.80e-01	6.49e-01	4.47e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	16	8.36e-01	8.73e-01	0.1670	-0.002520	0.018500	-9.65e-03	0.040300	-0.161000	9.86e-01	8.98e-01	9.47e-01	7.80e-01	2.66e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	9.02e-01	9.22e-01	0.1670	0.122000	0.066200	7.63e-02	0.038500	-0.034200	3.45e-01	6.09e-01	5.55e-01	7.66e-01	7.91e-01
CELL CYCLE	581	4.49e-08	5.46e-07	0.1660	0.009400	-0.001310	-9.02e-02	0.063000	-0.124000	7.00e-01	9.57e-01	2.18e-04	9.78e-03	3.55e-07
G ALPHA Q SIGNALLING EVENTS	141	2.39e-03	9.70e-03	0.1660	-0.063900	-0.013700	-9.21e-03	0.149000	0.031100	1.90e-01	7.79e-01	8.50e-01	2.23e-03	5.24e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	6.71e-01	7.42e-01	0.1660	-0.137000	-0.013700	2.29e-02	-0.076100	0.048200	2.03e-01	8.99e-01	8.31e-01	4.78e-01	6.54e-01
SIGNALING BY EGFR	46	2.41e-01	3.60e-01	0.1650	-0.061300	0.027100	6.49e-02	0.105000	0.088000	4.72e-01	7.50e-01	4.47e-01	2.20e-01	3.02e-01
TRNA PROCESSING IN THE NUCLEUS	56	2.56e-01	3.77e-01	0.1650	-0.075600	-0.012200	-1.28e-02	0.054200	-0.135000	3.28e-01	8.75e-01	8.68e-01	4.83e-01	8.01e-02
TP53 REGULATES METABOLIC GENES	84	3.62e-01	4.83e-01	0.1650	-0.033500	-0.068000	-5.44e-02	-0.034800	-0.131000	5.96e-01	2.82e-01	3.89e-01	5.82e-01	3.74e-02
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	7.83e-01	8.33e-01	0.1650	-0.140000	-0.041700	-5.95e-02	0.005870	-0.047400	1.52e-01	6.69e-01	5.42e-01	9.52e-01	6.28e-01
SIGNALING BY FGFR1	42	5.89e-01	6.74e-01	0.1650	-0.098700	0.001650	-5.86e-02	0.070900	-0.094400	2.69e-01	9.85e-01	5.11e-01	4.27e-01	2.90e-01
SIGNALING BY EGFR IN CANCER	21	7.90e-01	8.38e-01	0.1640	-0.139000	0.038300	-4.65e-02	-0.018600	-0.061400	2.71e-01	7.61e-01	7.12e-01	8.83e-01	6.26e-01
RHOH GTPASE CYCLE	37	8.58e-01	8.89e-01	0.1640	-0.023300	-0.041100	-9.85e-02	0.076500	-0.094800	8.06e-01	6.65e-01	3.00e-01	4.21e-01	3.19e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	218	2.30e-04	1.30e-03	0.1640	-0.008410	0.045900	2.58e-02	0.143000	-0.058000	8.31e-01	2.44e-01	5.12e-01	2.71e-04	1.41e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	281	1.02e-03	4.58e-03	0.1630	0.086000	0.101000	-6.14e-04	0.087600	0.038600	1.33e-02	3.70e-03	9.86e-01	1.18e-02	2.67e-01
NUCLEAR IMPORT OF REV PROTEIN	32	6.76e-01	7.45e-01	0.1630	-0.153000	-0.048900	-1.29e-02	-0.025700	-0.013100	1.35e-01	6.32e-01	9.00e-01	8.01e-01	8.98e-01
CELL CELL COMMUNICATION	103	5.67e-03	1.99e-02	0.1630	-0.105000	-0.088000	5.86e-02	0.051900	0.042200	6.60e-02	1.23e-01	3.05e-01	3.63e-01	4.59e-01
ESR MEDIATED SIGNALING	160	8.19e-02	1.63e-01	0.1630	-0.102000	-0.063100	-3.99e-02	-0.005840	-0.103000	2.65e-02	1.69e-01	3.84e-01	8.99e-01	2.45e-02
SIGNALING BY FGFR2	61	2.13e-01	3.29e-01	0.1630	0.072800	0.122000	-1.68e-02	0.029800	-0.071500	3.26e-01	9.96e-02	8.20e-01	6.87e-01	3.34e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	523	3.38e-04	1.85e-03	0.1620	-0.061000	-0.043200	-8.26e-02	-0.016800	-0.117000	1.75e-02	9.23e-02	1.29e-03	5.13e-01	5.20e-06
GLYCOLYSIS	65	5.40e-01	6.35e-01	0.1620	0.120000	0.006880	6.74e-02	0.085200	0.005550	9.57e-02	9.24e-01	3.48e-01	2.35e-01	9.38e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	22	7.29e-01	7.88e-01	0.1610	-0.102000	-0.065400	3.14e-02	-0.041600	-0.092700	4.07e-01	5.95e-01	7.99e-01	7.36e-01	4.52e-01
EPH EPHRIN SIGNALING	90	1.51e-02	4.55e-02	0.1610	-0.064200	-0.039400	6.54e-02	0.122000	-0.035200	2.93e-01	5.18e-01	2.84e-01	4.62e-02	5.64e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	81	1.62e-01	2.71e-01	0.1610	-0.001760	-0.081200	2.12e-02	0.137000	-0.001290	9.78e-01	2.07e-01	7.41e-01	3.34e-02	9.84e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	9.66e-01	9.74e-01	0.1600	0.060900	0.027600	1.30e-01	0.053300	0.036300	6.93e-01	8.58e-01	4.00e-01	7.30e-01	8.14e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	6.16e-01	6.99e-01	0.1590	-0.146000	-0.040200	-1.42e-03	-0.024800	-0.040500	1.40e-01	6.85e-01	9.89e-01	8.02e-01	6.83e-01
REGULATED PROTEOLYSIS OF P75NTR	12	9.36e-01	9.50e-01	0.1590	-0.028700	0.071300	1.02e-01	0.063100	0.070700	8.63e-01	6.69e-01	5.42e-01	7.05e-01	6.72e-01
RAB REGULATION OF TRAFFICKING	118	3.77e-02	9.14e-02	0.1590	0.019800	-0.046600	5.44e-02	0.126000	-0.061300	7.10e-01	3.82e-01	3.08e-01	1.81e-02	2.50e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	3.54e-01	4.77e-01	0.1580	-0.021800	0.012500	1.18e-01	0.011800	0.102000	7.72e-01	8.68e-01	1.18e-01	8.76e-01	1.77e-01
MYD88 INDEPENDENT TLR4 CASCADE	92	2.21e-01	3.35e-01	0.1570	-0.016000	-0.049500	-8.15e-03	0.102000	-0.108000	7.91e-01	4.12e-01	8.93e-01	9.04e-02	7.49e-02
RNA POLYMERASE III TRANSCRIPTION	41	3.65e-01	4.85e-01	0.1570	0.088900	0.076500	-1.88e-02	-0.093200	-0.043600	3.25e-01	3.97e-01	8.35e-01	3.02e-01	6.29e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	8.80e-01	9.05e-01	0.1570	-0.044800	-0.034900	-2.79e-02	0.138000	-0.038800	7.16e-01	7.77e-01	8.21e-01	2.62e-01	7.53e-01
RHO GTPASE CYCLE	420	2.13e-08	2.78e-07	0.1570	-0.062700	0.058300	7.34e-02	0.015700	0.108000	2.81e-02	4.10e-02	1.01e-02	5.82e-01	1.60e-04
INFECTIOUS DISEASE	711	4.68e-13	1.28e-11	0.1570	0.045200	0.040300	-3.99e-02	0.052900	-0.128000	4.14e-02	6.90e-02	7.19e-02	1.69e-02	6.75e-09
METABOLISM OF VITAMINS AND COFACTORS	146	1.05e-01	1.96e-01	0.1560	0.091000	0.026200	7.52e-02	0.096800	-0.022700	5.81e-02	5.86e-01	1.17e-01	4.38e-02	6.36e-01
SIGNALING BY FGFR3	33	6.33e-01	7.12e-01	0.1560	-0.022000	0.077700	-1.10e-02	0.133000	-0.013200	8.27e-01	4.40e-01	9.13e-01	1.87e-01	8.96e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	73	3.16e-01	4.37e-01	0.1550	-0.005490	-0.007750	-1.11e-01	0.098600	-0.044500	9.35e-01	9.09e-01	1.02e-01	1.46e-01	5.11e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	2.66e-01	3.86e-01	0.1530	-0.048000	0.006910	1.21e-01	0.075400	0.025000	5.95e-01	9.39e-01	1.78e-01	4.03e-01	7.82e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	135	1.20e-01	2.16e-01	0.1530	0.036900	-0.006860	-6.72e-02	0.093500	-0.093200	4.60e-01	8.91e-01	1.78e-01	6.11e-02	6.19e-02
SUMOYLATION	158	2.94e-01	4.16e-01	0.1530	-0.100000	-0.052300	-6.71e-02	-0.073500	-0.023900	2.95e-02	2.57e-01	1.46e-01	1.12e-01	6.05e-01
RHO GTPASES ACTIVATE PKNS	46	6.25e-01	7.07e-01	0.1530	-0.028300	-0.011800	-4.40e-02	0.013100	-0.142000	7.40e-01	8.90e-01	6.06e-01	8.78e-01	9.53e-02
VITAMIN B5 PANTOTHENATE METABOLISM	14	9.65e-01	9.74e-01	0.1520	0.011600	-0.013100	-5.16e-03	0.148000	-0.032500	9.40e-01	9.32e-01	9.73e-01	3.38e-01	8.33e-01
SARS COV INFECTIONS	139	8.45e-02	1.67e-01	0.1520	0.066100	0.026000	2.01e-02	0.111000	-0.073200	1.79e-01	5.97e-01	6.83e-01	2.38e-02	1.36e-01
VIRAL MESSENGER RNA SYNTHESIS	42	4.77e-01	5.81e-01	0.1520	-0.031300	-0.018500	5.33e-02	-0.129000	-0.048600	7.26e-01	8.36e-01	5.50e-01	1.49e-01	5.86e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	8.83e-01	9.07e-01	0.1510	0.003370	-0.026300	5.24e-02	-0.138000	0.020200	9.78e-01	8.31e-01	6.71e-01	2.62e-01	8.70e-01
SIGNALING BY ERBB2	47	6.06e-01	6.90e-01	0.1510	-0.123000	0.004220	-5.46e-02	0.010400	-0.069200	1.46e-01	9.60e-01	5.18e-01	9.02e-01	4.12e-01
ION CHANNEL TRANSPORT	135	1.82e-02	5.27e-02	0.1510	-0.043900	-0.034800	8.43e-02	-0.005660	0.112000	3.79e-01	4.85e-01	9.12e-02	9.10e-01	2.50e-02
TOLL LIKE RECEPTOR CASCADES	136	8.42e-02	1.66e-01	0.1500	-0.058600	-0.036900	-2.33e-02	0.066200	-0.114000	2.38e-01	4.58e-01	6.39e-01	1.83e-01	2.22e-02
RND1 GTPASE CYCLE	37	6.06e-01	6.90e-01	0.1500	-0.090500	-0.102000	-2.43e-02	0.021000	0.054500	3.41e-01	2.83e-01	7.98e-01	8.25e-01	5.66e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	5.81e-01	6.67e-01	0.1500	0.056500	0.027400	8.07e-02	0.030600	-0.106000	6.05e-01	8.02e-01	4.60e-01	7.79e-01	3.34e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	6.86e-01	7.52e-01	0.1490	-0.064200	-0.004820	6.29e-02	-0.093600	0.073600	4.72e-01	9.57e-01	4.81e-01	2.94e-01	4.09e-01
RHOG GTPASE CYCLE	73	5.41e-02	1.22e-01	0.1490	-0.094500	0.071100	3.87e-02	0.074600	0.034800	1.63e-01	2.94e-01	5.68e-01	2.71e-01	6.08e-01
CIRCADIAN CLOCK	68	2.64e-01	3.85e-01	0.1490	-0.133000	-0.029700	1.52e-02	-0.047800	0.035000	5.84e-02	6.72e-01	8.28e-01	4.96e-01	6.18e-01
SIGNALING BY FGFR4	31	7.70e-01	8.22e-01	0.1480	-0.026300	0.026800	-3.97e-02	0.137000	-0.019500	8.00e-01	7.96e-01	7.02e-01	1.88e-01	8.51e-01
UB SPECIFIC PROCESSING PROTEASES	165	3.65e-02	8.99e-02	0.1480	0.056400	-0.007290	-7.06e-02	0.075700	-0.089600	2.12e-01	8.72e-01	1.18e-01	9.39e-02	4.73e-02
NUCLEAR SIGNALING BY ERBB4	30	9.33e-01	9.48e-01	0.1480	0.068600	0.070500	4.44e-02	0.099700	0.017900	5.16e-01	5.04e-01	6.74e-01	3.45e-01	8.65e-01
DNA DOUBLE STRAND BREAK REPAIR	134	9.83e-02	1.88e-01	0.1480	-0.033900	-0.040100	-1.07e-02	-0.125000	-0.057000	4.99e-01	4.23e-01	8.30e-01	1.24e-02	2.55e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	9.35e-01	9.50e-01	0.1470	-0.019400	0.012000	3.74e-03	0.005270	-0.145000	9.11e-01	9.45e-01	9.83e-01	9.76e-01	4.04e-01
RNA POLYMERASE II TRANSCRIPTION	1069	1.13e-05	8.80e-05	0.1470	-0.077400	-0.048300	-7.57e-02	-0.047200	-0.073200	2.28e-05	8.21e-03	3.49e-05	9.82e-03	6.25e-05
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	9.08e-01	9.27e-01	0.1460	-0.103000	0.048300	-8.04e-02	-0.043900	-0.003010	4.36e-01	7.16e-01	5.44e-01	7.40e-01	9.82e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	42	3.58e-01	4.80e-01	0.1460	-0.006090	-0.072600	1.24e-01	-0.024200	0.010800	9.46e-01	4.16e-01	1.65e-01	7.87e-01	9.03e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	60	1.70e-01	2.80e-01	0.1460	-0.008570	-0.029000	7.25e-02	-0.100000	-0.071600	9.09e-01	6.98e-01	3.32e-01	1.79e-01	3.38e-01
HATS ACETYLATE HISTONES	90	1.75e-01	2.86e-01	0.1440	0.008620	-0.038200	1.11e-01	-0.069400	0.045700	8.88e-01	5.31e-01	6.95e-02	2.56e-01	4.54e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	6.98e-01	7.62e-01	0.1440	-0.026400	0.026200	9.41e-02	-0.042800	0.092600	7.51e-01	7.54e-01	2.60e-01	6.08e-01	2.67e-01
METABOLISM OF STEROIDS	110	5.13e-02	1.17e-01	0.1420	0.060100	0.000855	-4.52e-02	0.108000	0.053700	2.77e-01	9.88e-01	4.13e-01	5.15e-02	3.31e-01
VISUAL PHOTOTRANSDUCTION	55	3.84e-01	4.99e-01	0.1410	0.088500	-0.094000	9.06e-03	0.054900	-0.010000	2.56e-01	2.28e-01	9.08e-01	4.81e-01	8.98e-01
MAP2K AND MAPK ACTIVATION	36	4.88e-01	5.90e-01	0.1410	-0.056300	0.026000	1.04e-01	0.052500	0.049800	5.59e-01	7.87e-01	2.82e-01	5.86e-01	6.05e-01
NUCLEAR ENVELOPE BREAKDOWN	47	4.75e-01	5.79e-01	0.1400	-0.126000	-0.053300	6.92e-03	0.028600	-0.012900	1.37e-01	5.28e-01	9.35e-01	7.34e-01	8.78e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	6.35e-01	7.13e-01	0.1400	-0.136000	-0.009240	-1.56e-02	0.023800	0.011400	1.69e-01	9.26e-01	8.75e-01	8.11e-01	9.09e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	40	5.58e-01	6.50e-01	0.1400	0.048100	-0.097500	2.39e-02	0.065600	0.053300	5.99e-01	2.86e-01	7.93e-01	4.73e-01	5.60e-01
DNA REPAIR	288	1.15e-04	7.04e-04	0.1390	0.027000	-0.051100	-1.61e-02	-0.073200	-0.102000	4.31e-01	1.36e-01	6.38e-01	3.30e-02	2.95e-03
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	9.78e-01	9.83e-01	0.1390	0.095000	0.025100	8.65e-02	-0.041000	-0.022500	6.03e-01	8.91e-01	6.36e-01	8.22e-01	9.02e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	99	1.81e-01	2.92e-01	0.1380	0.033200	0.027100	8.86e-02	0.093800	-0.023700	5.69e-01	6.42e-01	1.28e-01	1.07e-01	6.84e-01
METABOLISM OF LIPIDS	600	3.94e-07	4.22e-06	0.1380	0.008210	-0.017400	2.58e-02	0.126000	-0.045900	7.33e-01	4.68e-01	2.83e-01	1.73e-07	5.59e-02
GENE SILENCING BY RNA	80	3.99e-01	5.13e-01	0.1360	-0.029900	-0.008060	3.93e-02	-0.127000	-0.003500	6.44e-01	9.01e-01	5.44e-01	4.99e-02	9.57e-01
ONCOGENIC MAPK SIGNALING	76	1.83e-01	2.94e-01	0.1360	-0.040600	-0.012900	7.67e-02	0.077700	0.068700	5.40e-01	8.46e-01	2.48e-01	2.42e-01	3.01e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	87	4.50e-01	5.62e-01	0.1350	-0.023500	-0.006170	-8.21e-02	-0.069800	-0.078400	7.05e-01	9.21e-01	1.86e-01	2.61e-01	2.07e-01
RHO GTPASE EFFECTORS	241	8.24e-04	3.85e-03	0.1350	-0.032300	0.037000	1.55e-02	0.111000	-0.055200	3.88e-01	3.23e-01	6.80e-01	2.95e-03	1.41e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	41	8.23e-01	8.64e-01	0.1340	-0.024800	-0.058700	-2.45e-02	-0.008300	-0.115000	7.84e-01	5.15e-01	7.86e-01	9.27e-01	2.01e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	57	3.85e-01	5.00e-01	0.1340	-0.132000	-0.012400	2.98e-03	-0.005500	-0.016000	8.40e-02	8.72e-01	9.69e-01	9.43e-01	8.34e-01
SIGNALING BY FGFR IN DISEASE	54	6.49e-01	7.26e-01	0.1340	-0.040000	0.034400	-7.63e-02	-0.055800	-0.078600	6.11e-01	6.62e-01	3.32e-01	4.78e-01	3.18e-01
RHOD GTPASE CYCLE	50	4.21e-01	5.32e-01	0.1340	-0.092600	0.009340	-5.79e-02	0.056800	0.051100	2.58e-01	9.09e-01	4.79e-01	4.87e-01	5.32e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	175	1.28e-02	3.96e-02	0.1330	0.044900	0.061400	4.51e-02	-0.091700	-0.039500	3.06e-01	1.62e-01	3.04e-01	3.67e-02	3.68e-01
SIGNALING BY INTERLEUKINS	335	1.87e-03	7.93e-03	0.1330	0.023600	0.035900	-4.87e-02	0.081900	-0.082600	4.59e-01	2.61e-01	1.27e-01	1.02e-02	9.54e-03
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	6.61e-01	7.34e-01	0.1330	-0.027900	-0.034300	1.36e-02	0.124000	-0.001430	7.46e-01	6.91e-01	8.75e-01	1.49e-01	9.87e-01
SIGNALING BY WNT	262	2.44e-02	6.64e-02	0.1320	0.022400	-0.002000	-2.71e-02	0.088600	-0.091800	5.34e-01	9.56e-01	4.52e-01	1.38e-02	1.07e-02
TRANSCRIPTIONAL REGULATION BY VENTX	35	7.73e-01	8.23e-01	0.1310	0.036900	-0.063200	7.70e-02	-0.049200	0.058500	7.06e-01	5.18e-01	4.31e-01	6.15e-01	5.49e-01
REGULATION OF PTEN GENE TRANSCRIPTION	57	4.93e-01	5.95e-01	0.1310	0.003750	0.075100	7.52e-02	0.075500	-0.007970	9.61e-01	3.27e-01	3.26e-01	3.24e-01	9.17e-01
POTENTIAL THERAPEUTICS FOR SARS	76	7.38e-01	7.96e-01	0.1300	0.051700	0.094500	6.30e-02	0.034100	0.016200	4.36e-01	1.55e-01	3.43e-01	6.07e-01	8.07e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	33	7.42e-01	7.99e-01	0.1300	0.001230	0.027200	-6.25e-02	0.106000	0.029800	9.90e-01	7.87e-01	5.34e-01	2.91e-01	7.67e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	9.71e-01	9.79e-01	0.1290	-0.002930	0.105000	-7.90e-03	0.058800	-0.045000	9.87e-01	5.45e-01	9.64e-01	7.36e-01	7.96e-01
SIGNALING BY FGFR	70	3.80e-01	4.98e-01	0.1280	0.031200	0.089300	-1.61e-02	0.040300	-0.075100	6.52e-01	1.97e-01	8.16e-01	5.60e-01	2.77e-01
MEIOTIC SYNAPSIS	38	6.27e-01	7.08e-01	0.1280	0.024100	0.084100	-9.83e-03	-0.045100	-0.081200	7.97e-01	3.70e-01	9.16e-01	6.30e-01	3.86e-01
SNRNP ASSEMBLY	51	7.91e-01	8.38e-01	0.1270	-0.024100	-0.010900	-5.08e-02	-0.009490	-0.113000	7.66e-01	8.93e-01	5.31e-01	9.07e-01	1.62e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	90	1.89e-01	3.01e-01	0.1270	-0.064200	-0.059200	2.62e-02	0.029900	-0.083300	2.93e-01	3.32e-01	6.68e-01	6.24e-01	1.72e-01
OXIDATIVE STRESS INDUCED SENESCENCE	77	3.21e-01	4.42e-01	0.1270	0.022900	0.023700	1.18e-01	-0.034400	0.002710	7.28e-01	7.20e-01	7.44e-02	6.02e-01	9.67e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	89	1.18e-01	2.13e-01	0.1270	-0.090200	0.074400	-2.14e-02	0.042800	0.011100	1.42e-01	2.26e-01	7.28e-01	4.86e-01	8.56e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	42	7.43e-01	8.00e-01	0.1260	-0.103000	-0.003180	-4.48e-02	0.052300	-0.020400	2.47e-01	9.72e-01	6.16e-01	5.58e-01	8.19e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	3.15e-01	4.37e-01	0.1250	-0.050200	-0.021000	8.07e-02	0.064500	0.045000	5.02e-01	7.78e-01	2.80e-01	3.88e-01	5.46e-01
SIGNALING BY PTK6	49	5.71e-01	6.61e-01	0.1240	-0.012000	0.058900	7.57e-02	0.076900	0.000201	8.84e-01	4.76e-01	3.59e-01	3.52e-01	9.98e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	6.32e-01	7.12e-01	0.1170	-0.086800	0.049000	1.84e-02	0.021900	0.054800	3.37e-01	5.87e-01	8.39e-01	8.09e-01	5.44e-01
MITOTIC PROMETAPHASE	173	6.14e-02	1.34e-01	0.1170	-0.018000	0.062600	-7.07e-02	0.055000	-0.038200	6.84e-01	1.56e-01	1.09e-01	2.13e-01	3.87e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	617	1.22e-06	1.15e-05	0.1160	-0.028200	0.054000	6.25e-02	0.050000	0.058800	2.35e-01	2.27e-02	8.42e-03	3.50e-02	1.32e-02
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	6.38e-01	7.15e-01	0.1160	0.010200	0.094000	3.82e-03	-0.007330	0.066700	8.77e-01	1.51e-01	9.53e-01	9.11e-01	3.08e-01
HEMOSTASIS	461	1.92e-06	1.70e-05	0.1160	-0.039300	0.029100	4.68e-02	0.093500	0.011100	1.50e-01	2.85e-01	8.65e-02	6.11e-04	6.84e-01
PI3K AKT SIGNALING IN CANCER	84	1.29e-01	2.29e-01	0.1160	-0.086100	-0.029000	5.93e-02	0.040700	0.003810	1.73e-01	6.47e-01	3.48e-01	5.20e-01	9.52e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	84	4.66e-01	5.73e-01	0.1130	0.014500	0.101000	-2.27e-02	-0.030600	0.031500	8.18e-01	1.10e-01	7.20e-01	6.28e-01	6.18e-01
SIGNALING BY NUCLEAR RECEPTORS	214	1.97e-01	3.10e-01	0.1120	-0.069200	-0.038600	-2.43e-02	0.024800	-0.071800	8.18e-02	3.31e-01	5.40e-01	5.32e-01	7.08e-02
DOWNSTREAM SIGNAL TRANSDUCTION	29	8.66e-01	8.94e-01	0.1120	-0.021100	-0.016400	2.15e-02	0.052500	0.092600	8.44e-01	8.79e-01	8.42e-01	6.25e-01	3.88e-01
MITOCHONDRIAL BIOGENESIS	92	2.85e-01	4.08e-01	0.1120	-0.059600	0.057900	2.06e-03	-0.056300	-0.049100	3.23e-01	3.38e-01	9.73e-01	3.51e-01	4.16e-01
AURKA ACTIVATION BY TPX2	71	6.64e-01	7.35e-01	0.1110	-0.008120	0.088200	-6.08e-03	-0.030600	0.060100	9.06e-01	1.99e-01	9.30e-01	6.56e-01	3.82e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	105	2.46e-01	3.67e-01	0.1100	-0.027400	-0.018500	5.20e-02	0.086200	0.027700	6.28e-01	7.43e-01	3.58e-01	1.27e-01	6.24e-01
LEISHMANIA INFECTION	182	1.26e-02	3.92e-02	0.1090	-0.082600	-0.035800	3.76e-02	0.043800	-0.020000	5.49e-02	4.06e-01	3.83e-01	3.08e-01	6.43e-01
DEUBIQUITINATION	238	2.54e-01	3.75e-01	0.1080	0.005610	-0.015900	-5.33e-02	0.047600	-0.079100	8.82e-01	6.72e-01	1.58e-01	2.07e-01	3.59e-02
BASIGIN INTERACTIONS	22	9.54e-01	9.66e-01	0.1070	-0.056100	-0.074400	1.85e-02	0.019300	-0.045700	6.49e-01	5.46e-01	8.81e-01	8.76e-01	7.11e-01
SENSORY PERCEPTION	133	5.85e-01	6.71e-01	0.1060	0.023700	0.018500	3.13e-02	-0.052100	0.081000	6.37e-01	7.13e-01	5.34e-01	3.00e-01	1.07e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	92	4.51e-01	5.63e-01	0.1050	-0.037600	-0.050300	1.86e-02	0.042900	-0.070300	5.33e-01	4.05e-01	7.58e-01	4.77e-01	2.44e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	7.05e-01	7.68e-01	0.1040	-0.003240	-0.017500	2.57e-02	-0.091200	-0.037900	9.65e-01	8.13e-01	7.29e-01	2.18e-01	6.08e-01
TRANSPORT OF SMALL MOLECULES	551	1.30e-04	7.85e-04	0.1020	-0.013100	-0.044800	3.17e-02	0.085000	0.005200	6.00e-01	7.37e-02	2.05e-01	6.89e-04	8.36e-01
TRNA PROCESSING	105	2.97e-01	4.20e-01	0.1010	0.005420	0.026800	-8.96e-04	-0.019200	-0.094800	9.24e-01	6.35e-01	9.87e-01	7.34e-01	9.35e-02
NERVOUS SYSTEM DEVELOPMENT	542	1.17e-02	3.67e-02	0.0985	0.022100	0.085900	4.13e-02	-0.003870	0.011200	3.82e-01	6.65e-04	1.02e-01	8.78e-01	6.58e-01
DOWNREGULATION OF ERBB2 SIGNALING	27	9.37e-01	9.50e-01	0.0976	-0.010300	0.070800	4.60e-02	-0.046100	-0.013400	9.26e-01	5.25e-01	6.79e-01	6.79e-01	9.04e-01
DEVELOPMENTAL BIOLOGY	793	1.80e-03	7.69e-03	0.0934	0.006140	0.062900	6.17e-02	-0.017600	0.024800	7.70e-01	2.79e-03	3.36e-03	4.02e-01	2.38e-01
SIGNALING BY NOTCH	186	4.62e-01	5.71e-01	0.0924	0.064000	0.035100	5.08e-02	0.018100	-0.017500	1.33e-01	4.10e-01	2.33e-01	6.71e-01	6.81e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	451	1.24e-04	7.52e-04	0.0921	-0.037500	0.016200	4.46e-02	0.068300	-0.012600	1.74e-01	5.56e-01	1.06e-01	1.33e-02	6.47e-01
CELLULAR SENESCENCE	139	4.05e-01	5.19e-01	0.0876	0.044300	0.002520	7.23e-02	-0.014400	-0.016100	3.67e-01	9.59e-01	1.42e-01	7.70e-01	7.43e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	7.90e-01	8.38e-01	0.0865	-0.000266	0.013700	-7.71e-02	0.013800	-0.034200	9.97e-01	8.38e-01	2.52e-01	8.38e-01	6.12e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	275	6.76e-02	1.43e-01	0.0853	-0.023400	0.014600	2.08e-02	0.073700	-0.025500	5.04e-01	6.77e-01	5.54e-01	3.60e-02	4.69e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	28	9.96e-01	9.97e-01	0.0852	-0.049900	-0.044100	-2.24e-02	-0.004540	-0.048000	6.48e-01	6.87e-01	8.37e-01	9.67e-01	6.61e-01
MAPK FAMILY SIGNALING CASCADES	282	5.78e-02	1.29e-01	0.0826	0.001280	0.040800	4.90e-02	0.045800	-0.025900	9.70e-01	2.40e-01	1.58e-01	1.87e-01	4.55e-01
TRANSCRIPTIONAL REGULATION BY TP53	338	1.41e-01	2.43e-01	0.0825	-0.008780	-0.009860	-2.16e-02	-0.023600	-0.074900	7.82e-01	7.56e-01	4.95e-01	4.58e-01	1.84e-02
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	51	8.57e-01	8.89e-01	0.0824	0.048800	0.033600	-1.40e-02	-0.051800	-0.020100	5.47e-01	6.78e-01	8.63e-01	5.23e-01	8.04e-01
REGULATION OF SIGNALING BY CBL	22	9.78e-01	9.83e-01	0.0774	-0.048700	0.036900	-2.54e-02	0.028800	0.028000	6.93e-01	7.65e-01	8.37e-01	8.15e-01	8.20e-01
SURFACTANT METABOLISM	16	9.98e-01	9.98e-01	0.0740	0.063300	0.019900	1.98e-02	0.021600	-0.014600	6.61e-01	8.90e-01	8.91e-01	8.81e-01	9.20e-01
NOD1 2 SIGNALING PATHWAY	34	9.93e-01	9.96e-01	0.0730	-0.001690	0.054900	3.46e-02	-0.012400	0.031000	9.86e-01	5.80e-01	7.27e-01	9.00e-01	7.55e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	9.95e-01	9.97e-01	0.0653	-0.043800	-0.022000	-4.40e-03	-0.035800	0.023500	6.73e-01	8.32e-01	9.66e-01	7.30e-01	8.21e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	359	3.89e-01	5.03e-01	0.0620	-0.004390	-0.002940	1.17e-02	0.058200	-0.017100	8.87e-01	9.24e-01	7.05e-01	5.91e-02	5.80e-01
DNA DOUBLE STRAND BREAK RESPONSE	51	9.98e-01	9.98e-01	0.0365	0.022400	0.000623	2.59e-03	0.010900	0.026600	7.82e-01	9.94e-01	9.74e-01	8.93e-01	7.43e-01
REGULATION OF TP53 ACTIVITY	148	9.92e-01	9.96e-01	0.0336	0.003970	0.025100	1.27e-02	0.016700	0.006570	9.34e-01	5.98e-01	7.90e-01	7.26e-01	8.90e-01

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Detailed Gene set reports

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

metric	value
setSize	19
pMANOVA	1.76e-10
p.adjustMANOVA	3.12e-09
s.dist	1.01
s.hyp	0.582
s.amy	0.156
s.hip	0.154
s.pag	0.695
s.ni	-0.383
p.hyp	1.11e-05
p.amy	0.239
p.hip	0.244
p.pag	1.53e-07
p.ni	0.00384

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Top 20 genes

Gene	pag	hyp
Tubb2a	7623	7422
Tuba1b	7377	7288
Tubb4b	7140	7429
Cct5	6862	7361
Tuba1a	6615	7304
Tubb4a	7042	6675
Cct3	6697	6694
Tubb2b	7029	5998
Tubb3	5443	6704
Tuba4a	6754	4780
Cct7	4504	6725
Cct4	5832	3517
Tubb6	1671	6888
Tuba1c	4166	2739
Cct2	3553	580

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cct2	580	-1970	-5948	3553	-6410
Cct3	6694	2898	-655	6697	-2600
Cct4	3517	41	-6870	5832	-6864
Cct5	7361	1555	1984	6862	-5371
Cct6a	-1913	-4657	-7245	7630	-7377
Cct7	6725	-2979	-879	4504	-5353
Cct8	-2035	-5	-7370	6059	-5003
Tcp1	-2955	-5259	-7116	6208	-6816
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875

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TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

metric	value
setSize	13
pMANOVA	1.72e-05
p.adjustMANOVA	0.000127
s.dist	0.973
s.hyp	0.593
s.amy	0.317
s.hip	0.449
s.pag	0.523
s.ni	-0.137
p.hyp	0.000212
p.amy	0.048
p.hip	0.00507
p.pag	0.00109
p.ni	0.391

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Top 20 genes

Gene	hyp	pag
Tubb2a	7422	7623
Tuba1b	7288	7377
Tubb4b	7429	7140
Tuba1a	7304	6615
Tubb4a	6675	7042
Tubb2b	5998	7029
Tubb3	6704	5443
Tuba4a	4780	6754
Tubb6	6888	1671
Tuba1c	2739	4166

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Gja1	-3988	-680	-6148	4747	-201
Gjb2	-3913	1771	-6720	-7781	-2806
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875

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POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY

metric	value
setSize	17
pMANOVA	1.09e-06
p.adjustMANOVA	1.03e-05
s.dist	0.942
s.hyp	0.63
s.amy	0.317
s.hip	0.503
s.pag	0.359
s.ni	-0.0846
p.hyp	6.77e-06
p.amy	0.0238
p.hip	0.000328
p.pag	0.0104
p.ni	0.546

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Top 20 genes

Gene	hyp	hip
Tubb2a	7422	7381
Tubb4b	7429	7351
Tubb4a	6675	7975
Tubb3	6704	7362
Tubb6	6888	6363
Tuba1b	7288	5658
Arl2	5877	6389
Tbcd	4678	7736
Tubb2b	5998	5135
Tuba1a	7304	4048
Tuba4a	4780	4171
Tbcb	6490	3071
Tuba1c	2739	6861
Tuba8	4396	955
Tbcc	2270	1304

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Arl2	5877	4519	6389	-1463	1288
Tbca	-940	3781	-6103	-4621	-4583
Tbcb	6490	4366	3071	-1523	-2419
Tbcc	2270	-137	1304	-2715	-1292
Tbcd	4678	2100	7736	6597	7794
Tbce	-2901	-5027	-2446	-5264	-446
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875

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ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY

metric	value
setSize	10
pMANOVA	0.000189
p.adjustMANOVA	0.00109
s.dist	0.864
s.hyp	-0.0885
s.amy	0.208
s.hip	0.457
s.pag	0.162
s.ni	0.679
p.hyp	0.628
p.amy	0.255
p.hip	0.0124
p.pag	0.376
p.ni	0.000202

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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	ni	hip
Adcy6	7849	7471
Adcy4	7838	7070
Adcy5	6600	6822
Adcy3	4851	5816
Adcy1	2895	5875
Adcy9	4862	3494
Gnal	4056	2171
Adcy2	5374	1614
Adcy7	4745	460

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Adcy1	-7887	-4317	5875	-6448	2895
Adcy2	-1096	1804	1614	4120	5374
Adcy3	6013	3347	5816	5038	4851
Adcy4	4857	7500	7070	6302	7838
Adcy5	-906	157	6822	2807	6600
Adcy6	7158	5234	7471	-1830	7849
Adcy7	593	3637	460	2166	4745
Adcy8	-6080	636	-1391	-413	6366
Adcy9	-3576	-3680	3494	-3786	4862
Gnal	-7345	-1599	2171	3939	4056

---

---

CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS

metric	value
setSize	13
pMANOVA	0.0177
p.adjustMANOVA	0.0514
s.dist	0.833
s.hyp	0.335
s.amy	0.401
s.hip	0.567
s.pag	0.0343
s.ni	0.311
p.hyp	0.0364
p.amy	0.0122
p.hip	0.000397
p.pag	0.83
p.ni	0.052

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	amy
Loxl3	7271	6687
Bmp1	4856	7404
Col4a2	5829	5371
Pcolce	6928	4478
Col1a2	2282	7094
Col1a1	5806	2463
Col4a5	3917	2357
Loxl1	7869	1170
Pxdn	6957	961
Col4a3	3519	1752
Tll2	4390	1103

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Bmp1	897	7404	4856	-1920	5919
Col1a1	570	2463	5806	-1758	5233
Col1a2	7095	7094	2282	3999	4117
Col4a1	-1187	-800	5236	-4567	3801
Col4a2	1223	5371	5829	-1888	5686
Col4a3	1870	1752	3519	-3788	2013
Col4a5	3796	2357	3917	4819	3481
Loxl1	5787	1170	7869	-5516	-5783
Loxl3	7215	6687	7271	7637	7577
Pcolce	4389	4478	6928	5339	-3897
Pxdn	2253	961	6957	-2124	7696
Tll1	-3087	-3531	-2226	-820	-2352
Tll2	2229	1103	4390	2873	579

---

---

MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1

metric	value
setSize	10
pMANOVA	0.0644
p.adjustMANOVA	0.139
s.dist	0.822
s.hyp	-0.364
s.amy	-0.541
s.hip	-0.361
s.pag	0.133
s.ni	-0.322
p.hyp	0.0464
p.amy	0.00308
p.hip	0.0481
p.pag	0.468
p.ni	0.078

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	hyp
Rap1b	-7939	-5638
Rap1a	-4973	-6910
Met	-7380	-3964
Gab1	-4585	-6095
Dock7	-6456	-4283
Crkl	-5218	-4794
Rac1	-6715	-3136
Crk	-4916	-2042

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Crk	-2042	-4916	-4692	907	-3721
Crkl	-4794	-5218	-4028	4760	-88
Dock7	-4283	-6456	-2328	-6781	2059
Gab1	-6095	-4585	2777	-3349	-3115
Grb2	2571	-3061	-1034	-415	-2932
Met	-3964	-7380	-4706	1081	-2312
Rac1	-3136	-6715	-4502	5613	-6666
Rap1a	-6910	-4973	-7618	1688	-7777
Rap1b	-5638	-7939	-7351	7512	-7029
Rapgef1	4133	4428	7847	-1447	7444

---

---

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

metric	value
setSize	23
pMANOVA	5.12e-07
p.adjustMANOVA	5.1e-06
s.dist	0.798
s.hyp	0.514
s.amy	0.259
s.hip	0.315
s.pag	0.423
s.ni	-0.167
p.hyp	2.01e-05
p.amy	0.0319
p.hip	0.00889
p.pag	0.000449
p.ni	0.165

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	pag
Tubb2a	7422	7623
Tuba1b	7288	7377
Tubb4b	7429	7140
Tuba1a	7304	6615
Tubb4a	6675	7042
Chmp7	6341	6698
Tubb2b	5998	7029
Chmp4b	7029	5632
Tubb3	6704	5443
Tuba4a	4780	6754
Vps4a	4170	6793
Tubb6	6888	1671
Tuba1c	2739	4166
Chmp6	5715	1587

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cc2d1b	3917	5138	5562	-4757	3546
Chmp2a	3519	1433	-708	-2410	-2935
Chmp2b	-7790	-7732	-6243	5923	-7647
Chmp3	-104	-2321	-5620	6654	-5642
Chmp4b	7029	5862	4566	5632	-1599
Chmp4c	-1950	-943	70	-7512	3113
Chmp6	5715	3846	4062	1587	-3263
Chmp7	6341	3004	2742	6698	698
Ist1	-1696	3824	-179	-3970	1582
Lemd2	7707	4872	8100	-967	6949
Spast	-3444	-7391	-7289	5524	-6565
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875
Vps4a	4170	2187	-3660	6793	-6181

---

---

CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY

metric	value
setSize	11
pMANOVA	0.0259
p.adjustMANOVA	0.0688
s.dist	0.79
s.hyp	-0.127
s.amy	-0.317
s.hip	-0.438
s.pag	0.394
s.ni	-0.4
p.hyp	0.467
p.amy	0.0686
p.hip	0.0118
p.pag	0.0236
p.ni	0.0217

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Cdc42	-7563	-7443
Pak1	-6355	-6495
Rac1	-4502	-6666
Pak2	-6411	-4425
Pak3	-7382	-3532
Cd86	-3111	-5661
Grb2	-1034	-2932

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cd80	-1470	4738	-2650	-4250	5314
Cd86	-1933	-6583	-3111	6008	-5661
Cdc42	-6532	-6427	-7563	3375	-7443
Fyn	2578	-3787	999	4094	-703
Grb2	2571	-3061	-1034	-415	-2932
Lck	5211	-4962	1273	3045	2202
Pak1	-4621	-6875	-6355	5947	-6495
Pak2	-2892	-2149	-6411	5493	-4425
Pak3	-3042	-3488	-7382	3323	-3532
Rac1	-3136	-6715	-4502	5613	-6666
Vav1	832	7354	1762	1191	-3019

---

---

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

metric	value
setSize	13
pMANOVA	0.0169
p.adjustMANOVA	0.0498
s.dist	0.762
s.hyp	0.41
s.amy	0.416
s.hip	0.438
s.pag	-0.14
s.ni	0.168
p.hyp	0.0105
p.amy	0.00935
p.hip	0.00625
p.pag	0.381
p.ni	0.295

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	amy
Ercc2	8217	7249
Pold1	5665	6363
Ciao3	7177	4791
Ndor1	5966	4924
Ciao2b	3632	7082
Nubp1	7316	3267
Rtel1	4992	4562
Ciapin1	4088	4802

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Abcb7	-6903	-1194	-7159	2732	-3959
Brip1	4236	4005	-4333	-5105	9
Ciao1	6308	-3356	1791	7141	-5953
Ciao2b	2567	7082	3632	-5704	3190
Ciao3	4215	4791	7177	549	446
Ciapin1	7500	4802	4088	4770	-514
Ercc2	6355	7249	8217	340	7726
Mms19	3146	-1504	7281	-6639	5438
Ndor1	-2583	4924	5966	-2198	2660
Nubp1	7201	3267	7316	-3236	4016
Nubp2	3677	-2938	4631	1948	-1230
Pold1	4855	6363	5665	-5367	3653
Rtel1	223	4562	4992	-4997	3760

---

---

ACTIVATION OF RAC1

ACTIVATION OF RAC1

metric	value
setSize	13
pMANOVA	0.0213
p.adjustMANOVA	0.0595
s.dist	0.759
s.hyp	-0.223
s.amy	-0.501
s.hip	-0.374
s.pag	0.229
s.ni	-0.288
p.hyp	0.165
p.amy	0.00176
p.hip	0.0195
p.pag	0.153
p.ni	0.0719

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	hip
Slit2	-8293	-5354
Pak1	-6875	-6355
Pak5	-4974	-6837
Rac1	-6715	-4502
Sos2	-5947	-5072
Sos1	-5637	-4811
Pak3	-3488	-7382
Pak2	-2149	-6411
Nck1	-502	-6086

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Nck1	-2501	-502	-6086	3607	-6055
Nck2	5982	-1039	5749	408	-1098
Pak1	-4621	-6875	-6355	5947	-6495
Pak2	-2892	-2149	-6411	5493	-4425
Pak3	-3042	-3488	-7382	3323	-3532
Pak4	4697	-1808	8000	-3182	6443
Pak5	-7486	-4974	-6837	-3075	-6763
Pak6	3745	-2583	3355	768	-2908
Rac1	-3136	-6715	-4502	5613	-6666
Robo1	-7258	-6769	1010	-351	3922
Slit2	199	-8293	-5354	6194	4142
Sos1	-3718	-5637	-4811	934	129
Sos2	-4586	-5947	-5072	-3250	-4598

---

---

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

metric	value
setSize	11
pMANOVA	0.0165
p.adjustMANOVA	0.0489
s.dist	0.757
s.hyp	-0.377
s.amy	-0.437
s.hip	-0.385
s.pag	0.27
s.ni	-0.138
p.hyp	0.0304
p.amy	0.0121
p.hip	0.0269
p.pag	0.121
p.ni	0.428

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hip
Prkacb	-8088	-7191
Prkar1a	-7566	-6866
Prkar2b	-7906	-6489
Creb1	-7240	-7039
Calm1	-6439	-7281
Prkx	-6775	-4463

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Adcy1	-7887	-4317	5875	-6448	2895
Adcy8	-6080	636	-1391	-413	6366
Calm1	-7409	-6439	-7281	419	-6180
Creb1	-3974	-7240	-7039	6468	-3715
Prkaca	5015	1686	4123	-1465	2496
Prkacb	-3255	-8088	-7191	5203	-4968
Prkar1a	-1943	-7566	-6866	6644	-4777
Prkar1b	5079	-518	3124	6501	-496
Prkar2a	-141	4106	-2733	1608	1893
Prkar2b	-7419	-7906	-6489	3685	-4526
Prkx	-6320	-6775	-4463	346	538

---

---

GAP JUNCTION ASSEMBLY

GAP JUNCTION ASSEMBLY

metric	value
setSize	21
pMANOVA	2.15e-05
p.adjustMANOVA	0.000154
s.dist	0.745
s.hyp	0.438
s.amy	0.226
s.hip	0.32
s.pag	0.439
s.ni	-0.133
p.hyp	0.000507
p.amy	0.0728
p.hip	0.0112
p.pag	0.000502
p.ni	0.29

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	pag	hyp
Tubb2a	7623	7422
Tuba1b	7377	7288
Tubb4b	7140	7429
Tuba1a	6615	7304
Tubb4a	7042	6675
Tubb2b	7029	5998
Gjb6	7099	5438
Tubb3	5443	6704
Tuba4a	6754	4780
Gjd3	5552	4894
Tubb6	1671	6888
Tuba1c	4166	2739

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Gja1	-3988	-680	-6148	4747	-201
Gja4	7101	5229	2552	-1209	829
Gja5	2615	1968	-3333	-6763	2119
Gjb1	-753	-5774	4772	3574	-4136
Gjb2	-3913	1771	-6720	-7781	-2806
Gjb6	5438	7456	-1108	7099	1734
Gjc1	-3835	-1881	-715	2309	1141
Gjc2	-1034	601	6763	1299	-780
Gjd2	-3581	158	-3460	6507	-6935
Gjd3	4894	-5811	3928	5552	-855
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875

---

---

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

metric	value
setSize	29
pMANOVA	1.07e-05
p.adjustMANOVA	8.38e-05
s.dist	0.736
s.hyp	-0.0487
s.amy	-0.222
s.hip	-0.402
s.pag	0.323
s.ni	-0.474
p.hyp	0.65
p.amy	0.0387
p.hip	0.000178
p.pag	0.00262
p.ni	9.91e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	ni	hip
Ube2w	-7769	-7429
Ube2q2	-7596	-7303
Ube2g1	-7713	-7162
Ube2d1	-7638	-7228
Ube2e1	-7396	-7451
Ube2k	-7230	-7493
Ube2e3	-7766	-6927
Ube2b	-7366	-7171
Ube2l3	-7256	-6908
Ube2a	-7345	-6484
Ube2d2a	-7128	-6473
Uchl3	-7460	-4655
Ube2r2	-5062	-3947
Uba6	-3073	-5664
Usp9x	-2188	-6653
Rps27a	-3743	-3760
Otulin	-4125	-2965
Ube2t	-3191	-2385

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cdc34	4685	-121	2730	1987	-4077
Otulin	656	1008	-2965	-5726	-4125
Rps27a	2369	5544	-3760	-441	-3743
Uba1	2171	967	2941	4692	3955
Uba52	4278	3663	1163	-7268	3245
Uba6	-2733	-2909	-5664	7192	-3073
Ubb	6745	2477	5261	1194	-3834
Ubc	2439	2921	4638	4180	3064
Ube2a	-1115	-5814	-6484	6543	-7345
Ube2b	-5599	-6128	-7171	4716	-7366
Ube2d1	-7771	-7537	-7228	-2127	-7638
Ube2d2a	-2196	-6905	-6473	6230	-7128
Ube2e1	-5304	-3425	-7451	3366	-7396
Ube2e3	-3666	-5288	-6927	1598	-7766
Ube2g1	-6360	-4553	-7162	5287	-7713
Ube2g2	1532	-125	5982	2049	2428
Ube2h	-4410	-1683	-2692	1257	1997
Ube2k	-6855	-5135	-7493	1353	-7230
Ube2l3	-4177	-5685	-6908	5292	-7256
Ube2q2	-6542	-4911	-7303	5922	-7596
Ube2r2	3268	-999	-3947	-221	-5062
Ube2s	6527	22	472	1444	-4243
Ube2t	617	4012	-2385	-4394	-3191
Ube2w	-4749	-6867	-7429	5639	-7769
Ube2z	5695	-1987	2140	4965	-1066
Uchl3	6519	-7450	-4655	6279	-7460
Usp5	6658	2326	4526	7211	1969
Usp7	-1879	-842	-2825	447	2635
Usp9x	-5597	-6790	-6653	2907	-2188

---

---

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

metric	value
setSize	26
pMANOVA	2.18e-08
p.adjustMANOVA	2.8e-07
s.dist	0.733
s.hyp	0.387
s.amy	0.165
s.hip	0.0234
s.pag	0.461
s.ni	-0.384
p.hyp	0.000646
p.amy	0.146
p.hip	0.836
p.pag	4.79e-05
p.ni	0.000695

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	hyp
Tubb2a	7623	7422
Tuba1b	7377	7288
Tubb4b	7140	7429
Cct5	6862	7361
Tuba1a	6615	7304
Tubb4a	7042	6675
Cct3	6697	6694
Tubb2b	7029	5998
Tubb3	5443	6704
Tuba4a	6754	4780
Cct7	4504	6725
Cct4	5832	3517
Tubb6	1671	6888
Tuba1c	4166	2739
Cct2	3553	580
Pfdn1	529	3825

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Actb	-6900	-2671	4643	-7405	-2371
Cct2	580	-1970	-5948	3553	-6410
Cct3	6694	2898	-655	6697	-2600
Cct4	3517	41	-6870	5832	-6864
Cct5	7361	1555	1984	6862	-5371
Cct6a	-1913	-4657	-7245	7630	-7377
Cct7	6725	-2979	-879	4504	-5353
Cct8	-2035	-5	-7370	6059	-5003
Pfdn1	3825	3351	-1244	529	-3930
Pfdn2	806	7460	-1909	-4450	3551
Pfdn4	-5809	-1254	-6647	4209	-6823
Pfdn5	1573	2305	-882	-2907	-1869
Pfdn6	3590	5922	-2832	-3467	-1382
Tcp1	-2955	-5259	-7116	6208	-6816
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875
Vbp1	-6038	-7329	-7465	2945	-7677

---

---

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

metric	value
setSize	12
pMANOVA	0.00224
p.adjustMANOVA	0.00926
s.dist	0.72
s.hyp	0.152
s.amy	0.367
s.hip	0.0551
s.pag	0.591
s.ni	0.0984
p.hyp	0.361
p.amy	0.0278
p.hip	0.741
p.pag	0.000397
p.ni	0.555

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	amy
Elovl1	7001	7567
Fads1	7715	4916
Fads2	7800	4558
Hsd17b4	6139	4694
Acaa1a	4923	5758
Acot8	3288	5495
Abcd1	1729	5403
Scp2	3533	1528
Elovl5	2447	390

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Abcd1	2437	5403	6879	1729	7058
Acaa1a	7368	5758	7392	4923	4354
Acot8	7355	5495	7790	3288	5046
Acox1	-353	-5056	-2228	5657	-80
Acsl1	-6973	-4003	-2647	2525	542
Elovl1	3247	7567	7021	7001	-2388
Elovl2	-6518	-855	-4915	2428	-5885
Elovl5	-5714	390	-5581	2447	-4350
Fads1	6764	4916	398	7715	5344
Fads2	7324	4558	3488	7800	6395
Hsd17b4	142	4694	-3002	6139	1828
Scp2	-2032	1528	-5649	3533	-6722

---

---

CGMP EFFECTS

CGMP EFFECTS

metric	value
setSize	15
pMANOVA	0.0037
p.adjustMANOVA	0.0141
s.dist	0.717
s.hyp	-0.56
s.amy	-0.302
s.hip	-0.227
s.pag	-0.241
s.ni	0.018
p.hyp	0.000175
p.amy	0.0431
p.hip	0.128
p.pag	0.106
p.ni	0.904

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	amy
Pde1a	-7443	-8246
Kcnma1	-6805	-7234
Prkg1	-4724	-6308
Pde2a	-6949	-3513
Itpr1	-6908	-3530
Pde10a	-7599	-2103
Pde11a	-3618	-4006
Pde5a	-6280	-1789
Kcnmb4	-3554	-2729

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Irag1	-1149	1924	1960	-2081	4566
Itpr1	-6908	-3530	-770	-5932	800
Kcnma1	-6805	-7234	-5595	-4828	4858
Kcnmb1	4222	-5485	-5386	1785	3213
Kcnmb2	-8067	1486	-4902	-2598	-5837
Kcnmb4	-3554	-2729	1374	-2457	-7330
Pde10a	-7599	-2103	2753	-4237	4195
Pde11a	-3618	-4006	-1822	-6517	4844
Pde1a	-7443	-8246	-5234	1503	-2833
Pde1b	-7660	303	5425	1396	3843
Pde2a	-6949	-3513	5284	526	-759
Pde5a	-6280	-1789	-4561	-5350	-3385
Pde9a	2408	-2780	-711	-467	-2500
Prkg1	-4724	-6308	-4240	-2649	-2494
Prkg2	-4452	2291	-6027	1706	3157

---

---

REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS

metric	value
setSize	11
pMANOVA	0.0185
p.adjustMANOVA	0.0529
s.dist	0.717
s.hyp	-0.554
s.amy	-0.305
s.hip	-0.2
s.pag	-0.266
s.ni	0.0578
p.hyp	0.00146
p.amy	0.0803
p.hip	0.252
p.pag	0.127
p.ni	0.74

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Top 20 genes

Gene	hyp	amy
Slc8a1	-7679	-8128
Calm1	-7409	-6439
Atp2b4	-7261	-6307
Atp2b1	-7969	-4364
Sri	-6325	-3584
Atp2a2	-3967	-5282
Atp2a3	-6677	-982
Atp2b3	-1265	-249

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Atp2a2	-3967	-5282	-2888	1857	1170
Atp2a3	-6677	-982	4469	-5987	-872
Atp2b1	-7969	-4364	-5083	-7907	115
Atp2b2	-6479	386	1727	-6199	3781
Atp2b3	-1265	-249	3466	-3657	3302
Atp2b4	-7261	-6307	-3762	-2568	7225
Calm1	-7409	-6439	-7281	419	-6180
Slc8a1	-7679	-8128	-5965	-3748	-2112
Slc8a2	3853	-936	7584	857	3233
Slc8a3	1349	5034	493	-436	4169
Sri	-6325	-3584	-6848	3053	-7169

---

---

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

metric	value
setSize	12
pMANOVA	0.0194
p.adjustMANOVA	0.0551
s.dist	0.715
s.hyp	-0.11
s.amy	-0.152
s.hip	-0.527
s.pag	0.0253
s.ni	-0.445
p.hyp	0.511
p.amy	0.362
p.hip	0.00158
p.pag	0.879
p.ni	0.00758

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Top 20 genes

Gene	hip	ni
Spcs3	-7357	-7246
Spcs2	-7495	-5753
Spcs1	-5111	-5007
Dpp4	-6559	-2218
Sec11c	-3318	-4204
Tcf7l2	-2595	-4998
Pax6	-1638	-5784
Grp	-1185	-3872
Pcsk1	-6742	-662
Sec11a	-3336	-531

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ctnnb1	-2284	-4564	-2053	6367	1314
Dpp4	-3157	-6389	-6559	-6065	-2218
Gng13	3044	-3521	820	-5937	-1764
Grp	5515	-5746	-1185	1232	-3872
Pax6	-7834	-2107	-1638	-6310	-5784
Pcsk1	5418	-1586	-6742	7409	-662
Sec11a	-201	3067	-3336	4439	-531
Sec11c	-955	3945	-3318	-2748	-4204
Spcs1	2401	732	-5111	1559	-5007
Spcs2	-320	-1082	-7495	-58	-5753
Spcs3	-7675	-6722	-7357	4405	-7246
Tcf7l2	-5888	4874	-2595	-3042	-4998

---

---

PHASE 2 PLATEAU PHASE

PHASE 2 PLATEAU PHASE

metric	value
setSize	10
pMANOVA	0.107
p.adjustMANOVA	0.198
s.dist	0.706
s.hyp	0.158
s.amy	0.161
s.hip	0.395
s.pag	-0.185
s.ni	0.507
p.hyp	0.387
p.amy	0.378
p.hip	0.0304
p.pag	0.312
p.ni	0.00553

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	ni	hip
Cacng8	6979	7616
Cacng4	5701	6211
Cacna1c	6705	5254
Cacnb1	5418	6196
Cacng7	2126	6667
Cacna2d2	5110	2380
Kcne1l	1942	2871
Cacnb2	833	60

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Akap9	-856	265	-2869	-3753	7413
Cacna1c	1617	-536	5254	-3540	6705
Cacna2d2	-2371	805	2380	-4246	5110
Cacnb1	937	-2945	6196	2472	5418
Cacnb2	-4570	-3448	60	-4547	833
Cacng4	4163	2727	6211	-6613	5701
Cacng7	-3592	1763	6667	-79	2126
Cacng8	3344	-955	7616	-298	6979
Kcne1l	7813	6302	2871	7691	1942
Kcne4	4853	5007	130	-2753	-474

---

---

PROCESSING AND ACTIVATION OF SUMO

PROCESSING AND ACTIVATION OF SUMO

metric	value
setSize	10
pMANOVA	0.0315
p.adjustMANOVA	0.0795
s.dist	0.704
s.hyp	0.0186
s.amy	-0.296
s.hip	-0.477
s.pag	0.229
s.ni	-0.357
p.hyp	0.919
p.amy	0.105
p.hip	0.00903
p.pag	0.209
p.ni	0.0503

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Top 20 genes

Gene	hip	ni
Sumo1	-7182	-7079
Sumo2	-7085	-7170
Rwdd3	-5975	-6027
Uba2	-2814	-4190
Ube2i	-4965	-2119
Senp2	-3199	-2363
Sumo3	-1470	-4966
Sae1	-908	-33

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Rwdd3	-247	-5009	-5975	-4171	-6027
Sae1	5821	6650	-908	5231	-33
Senp1	3036	541	2646	-5816	5096
Senp2	-3669	-1410	-3199	-1175	-2363
Senp5	-4756	-5400	-3897	-3783	1886
Sumo1	-3773	-6024	-7182	4446	-7079
Sumo2	-6331	-5008	-7085	5372	-7170
Sumo3	4743	-2467	-1470	5954	-4966
Uba2	6454	-3429	-2814	6104	-4190
Ube2i	-1031	-5843	-4965	5111	-2119

---

---

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

metric	value
setSize	11
pMANOVA	0.0116
p.adjustMANOVA	0.0366
s.dist	0.703
s.hyp	0.0315
s.amy	-0.252
s.hip	-0.0582
s.pag	0.545
s.ni	-0.358
p.hyp	0.857
p.amy	0.148
p.hip	0.738
p.pag	0.00174
p.ni	0.0396

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Top 20 genes

Gene	pag	ni
Rab2a	6043	-7739
Rab1a	5732	-6832
Mapk1	6645	-5590
Mapk3	7215	-4692
Uso1	6408	-4872
Blzf1	4637	-6717
Gorasp2	7064	-3798
Rab1b	5893	-2541

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Blzf1	-7585	-5267	-6425	4637	-6717
Golga2	5589	6948	7024	-2889	7809
Gorasp1	4633	-2701	7409	3815	5530
Gorasp2	779	-5956	3594	7064	-3798
Mapk1	-7830	-8169	-4425	6645	-5590
Mapk3	4330	-617	4642	7215	-4692
Plk1	5870	7552	-522	-3938	-305
Rab1a	-4955	-5312	-7210	5732	-6832
Rab1b	6613	-3691	6537	5893	-2541
Rab2a	-4637	-8165	-7241	6043	-7739
Uso1	-1408	-885	-5101	6408	-4872

---

---

RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE

metric	value
setSize	10
pMANOVA	0.0428
p.adjustMANOVA	0.1
s.dist	0.698
s.hyp	0.0102
s.amy	-0.146
s.hip	-0.239
s.pag	0.534
s.ni	-0.353
p.hyp	0.955
p.amy	0.424
p.hip	0.19
p.pag	0.00348
p.ni	0.0535

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Top 20 genes

Gene	pag	ni
Cul3	5425	-7481
Rab9b	5523	-5092
Ccne1	6961	-3338
Vhl	2086	-5569
Plin3	4897	-1443
Rhobtb3	372	-6306

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ccne1	-1787	2787	1743	6961	-3338
Cul3	-6897	-7037	-7565	5425	-7481
Hgs	6231	4544	6369	4969	4557
Htr7	7311	1681	1282	7396	2693
Lrrc41	1224	-4953	4229	4259	908
Plin3	6055	6560	-341	4897	-1443
Rab9	-4566	-457	-5573	-421	-5512
Rab9b	483	-3447	-7214	5523	-5092
Rhobtb3	-6386	-7597	-7004	372	-6306
Vhl	-2086	-7531	-1887	2086	-5569

---

---

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

metric	value
setSize	10
pMANOVA	0.0753
p.adjustMANOVA	0.154
s.dist	0.691
s.hyp	-0.0983
s.amy	-0.242
s.hip	-0.383
s.pag	0.412
s.ni	-0.304
p.hyp	0.59
p.amy	0.186
p.hip	0.036
p.pag	0.0241
p.ni	0.0957

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Top 20 genes

Gene	pag	hip
Ywhaq	5562	-6522
Ywhab	4548	-7158
Ywhae	2628	-7209
Chek1	5635	-1878
Ywhah	3452	-2397
Ywhaz	1080	-7029
Wee1	3446	-939

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Chek1	-5381	-4931	-1878	5635	1044
Chek2	2789	1222	-4443	-1273	1242
Sfn	7023	5347	5585	5826	7623
Wee1	2172	5182	-939	3446	-3822
Ywhab	-6189	-8153	-7158	4548	-7091
Ywhae	-5262	-4166	-7209	2628	-6740
Ywhag	3714	-2392	4611	881	3938
Ywhah	2126	-1295	-2397	3452	-4772
Ywhaq	-2420	-6466	-6522	5562	-7742
Ywhaz	-7618	-7406	-7029	1080	-6416

---

---

MATURATION OF NUCLEOPROTEIN

MATURATION OF NUCLEOPROTEIN

metric	value
setSize	10
pMANOVA	0.154
p.adjustMANOVA	0.261
s.dist	0.685
s.hyp	-0.339
s.amy	-0.165
s.hip	-0.34
s.pag	-0.34
s.ni	-0.31
p.hyp	0.0635
p.amy	0.367
p.hip	0.0623
p.pag	0.0627
p.ni	0.0897

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	pag
Parp14	-4437	-8024
Gsk3b	-4855	-5115
Parp9	-4312	-5401
Parp10	-1771	-7094
Parp4	-1233	-7799

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Gsk3b	-7097	-5615	-4855	-5115	848
Parp10	3913	149	-1771	-7094	-5419
Parp14	-8001	-8254	-4437	-8024	-5167
Parp16	-1341	-2301	595	-1445	-2456
Parp4	-3655	968	-1233	-7799	-784
Parp6	-4354	2269	1670	-888	1520
Parp8	13	4355	2486	-1799	3724
Parp9	-2851	3366	-4312	-5401	-6256
Sumo1	-3773	-6024	-7182	4446	-7079
Ube2i	-1031	-5843	-4965	5111	-2119

---

---

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

metric	value
setSize	17
pMANOVA	0.000168
p.adjustMANOVA	0.00097
s.dist	0.684
s.hyp	-0.13
s.amy	0.0211
s.hip	0.272
s.pag	-0.248
s.ni	0.561
p.hyp	0.352
p.amy	0.88
p.hip	0.0524
p.pag	0.0772
p.ni	6.15e-05

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Top 20 genes

Gene	ni	hip
Mov10	6529	6972
Pml	6030	6473
Ptpn11	6531	5779
Src	4786	7836
Ago2	7388	4165
Ago1	6052	4470
Ccnd3	1952	7373
Ago3	7782	1589
Tnrc6c	4535	2716
Cdk6	5836	2008
Ccnd2	2971	3726
Tnrc6a	7200	104

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ago1	-1680	-2434	4470	-122	6052
Ago2	-1088	-490	4165	-1325	7388
Ago3	-1085	3862	1589	-4550	7782
Ago4	-2590	-902	-2106	-899	5085
Cbfb	-3387	-2215	-6680	5687	-2565
Ccnd1	-4604	-4373	-1323	-449	-4450
Ccnd2	-4798	-4377	3726	50	2971
Ccnd3	6403	4670	7373	6404	1952
Cdk6	-1472	-2178	2008	-6800	5836
Mov10	1773	6105	6972	-5959	6529
Pml	-712	7399	6473	-5603	6030
Ptpn11	4221	4122	5779	3491	6531
Runx1	389	-1553	-958	-4496	4897
Src	3784	245	7836	2368	4786
Tnrc6a	-4416	2204	104	-7484	7200
Tnrc6b	-3081	-6096	-192	-7433	7770
Tnrc6c	-7371	-7652	2716	-7983	4535

---

---

ACTIVATION OF SMO

ACTIVATION OF SMO

metric	value
setSize	16
pMANOVA	0.0551
p.adjustMANOVA	0.124
s.dist	0.676
s.hyp	0.214
s.amy	0.3
s.hip	0.426
s.pag	0.0957
s.ni	0.361
p.hyp	0.139
p.amy	0.0379
p.hip	0.0032
p.pag	0.508
p.ni	0.0124

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Evc	6942	8025
Arrb2	7967	6942
Iqce	6510	7561
Gas8	6584	7400
Evc2	7743	4351
Arrb1	4219	7791
Smo	7378	2740
Ptch1	1640	6500
Cdon	2595	990

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Arrb1	1262	4305	4219	1356	7791
Arrb2	6934	7482	7967	1553	6942
Boc	-5334	-778	6358	-6243	-2023
Cdon	-6082	-3710	2595	-7251	990
Csnk1a1	-4737	-8072	-6107	770	-6314
Efcab7	-7322	-8025	-4769	4586	746
Evc	7300	6574	6942	3802	8025
Evc2	7241	4920	7743	5342	4351
Gas1	6069	4236	6069	931	-95
Gas8	7373	7385	6584	4001	7400
Grk2	6871	43	7231	7572	-767
Iqce	6766	5806	6510	-2859	7561
Kif3a	176	4935	-1228	-7412	7530
Ptch1	-72	2808	1640	3120	6500
Shh	-6242	485	-72	-3346	-3134
Smo	5037	3611	7378	4698	2740

---

---

IRE1ALPHA ACTIVATES CHAPERONES

IRE1ALPHA ACTIVATES CHAPERONES

metric	value
setSize	49
pMANOVA	6.89e-07
p.adjustMANOVA	6.64e-06
s.dist	0.675
s.hyp	0.416
s.amy	0.218
s.hip	0.262
s.pag	0.354
s.ni	0.202
p.hyp	4.72e-07
p.amy	0.00841
p.hip	0.00154
p.pag	1.83e-05
p.ni	0.0144

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	pag
Pdia6	7686	7832
Hspa5	6928	7790
Xbp1	6736	7742
Dnajb11	7176	7076
Preb	7700	5758
Lmna	7431	5855
Tpp1	5203	7843
Dnajc3	4928	7824
Srprb	5326	7205
Dctn1	6550	5774
Cxxc1	7390	4818
Srpr	6056	5864
Yif1a	6247	5230
Hyou1	5562	5743
Syvn1	6597	4805
Ppp2r5b	4877	5362
Gosr2	5612	4634
Add1	5016	4481
Gsk3a	5073	4419
Klhdc3	6606	3333

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acadvl	5813	737	1260	-4938	4842
Add1	5016	2068	5078	4481	6372
Arfgap1	5363	-1151	4848	-577	5195
Atp6v0d1	2509	-3674	2203	7111	-4558
Ctdsp2	-2514	5784	7764	-460	7045
Cul7	7372	3395	6460	-161	8037
Cxxc1	7390	6053	7572	4818	7384
Dctn1	6550	4613	6737	5774	5591
Ddx11	3998	1574	4399	-7	4370
Dnajb11	7176	4400	-4670	7076	-2461
Dnajb9	-6525	-4787	-7637	6602	-7701
Dnajc3	4928	2472	-4263	7824	-324
Edem1	-4960	-2588	-3657	-966	1326
Ern1	-1413	-7425	2147	-979	6070
Extl1	-4465	-4171	5842	-3478	3475
Extl2	-7399	-4913	-6840	1662	-6222
Extl3	2345	801	6167	120	7282
Fkbp14	3907	-5569	-3839	3476	-3560
Gfpt1	-3425	-1718	-5286	6606	1505
Gosr2	5612	-496	1741	4634	555
Gsk3a	5073	3132	6349	4419	2836
Hdgf	7015	7443	-2859	2422	958
Hspa5	6928	4930	-3463	7790	-3572
Hyou1	5562	4677	4020	5743	5698
Klhdc3	6606	2156	3827	3333	1160
Lmna	7431	911	4716	5855	1729
Mydgf	6643	-1435	4871	-390	-4005
Pdia5	3685	3346	5353	-6046	1771
Pdia6	7686	5776	2776	7832	1525
Pla2g4b	5242	-6010	6372	326	4248
Ppp2r5b	4877	7364	8015	5362	-2736
Preb	7700	6749	7660	5758	5125
Sec31a	-1219	4189	4386	2476	4611
Serp1	-4084	-7877	-6617	4035	-6610
Shc1	2690	6901	5484	1214	5531
Srpr	6056	4555	3024	5864	844
Srprb	5326	3598	4284	7205	1577
Ssr1	-4210	-5372	-7445	4895	-6679
Sult1a1	4265	6674	-1723	-405	2753
Syvn1	6597	1587	8092	4805	4846
Tatdn2	749	-4619	3303	-2426	1172
Tln1	7242	7191	7919	523	8026
Tpp1	5203	5275	7565	7843	2348
Tspyl2	5597	5659	3279	-18	4170
Wfs1	-4565	-723	4958	-2620	4605
Wipi1	-1931	-6057	-1867	-5900	2596
Xbp1	6736	3438	-2497	7742	-4027
Yif1a	6247	104	3055	5230	-4432
Zbtb17	3249	6877	7889	1319	5478

---

---

INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS

metric	value
setSize	27
pMANOVA	8.32e-08
p.adjustMANOVA	9.61e-07
s.dist	0.674
s.hyp	-0.253
s.amy	0.0476
s.hip	0.223
s.pag	-0.273
s.ni	0.513
p.hyp	0.0228
p.amy	0.669
p.hip	0.0446
p.pag	0.014
p.ni	3.87e-06

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Top 20 genes

Gene	ni	pag
Scn8a	7318	-7566
Ank3	6821	-7687
Ank2	7511	-5457
Ank1	5911	-4805
Scn9a	4759	-5341
Scn2b	5442	-4585
Sptbn4	8065	-3088
Scn3a	2994	-5460
Scn2a	2190	-7005
Sptb	6126	-2427
Sptbn2	5981	-2128
Kcnq3	1858	-5606
Kcnq2	7587	-1180
Scn4b	3044	-2757
Nfasc	7999	-917
Sptbn1	5862	-776
Scn1a	1400	-3245
Scn5a	5676	-714

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Actb	-6900	-2671	4643	-7405	-2371
Actg1	-2568	-3511	725	1840	-5668
Ank1	2222	3688	2546	-4805	5911
Ank2	-2867	1128	3177	-5457	7511
Ank3	-6788	783	-651	-7687	6821
Kcnq2	-1877	-957	6664	-1180	7587
Kcnq3	-7332	-4878	-3628	-5606	1858
L1cam	3308	3387	4993	3088	5774
Nfasc	147	5850	7291	-917	7999
Nrcam	-4626	-7809	-1237	647	3058
Scn1a	-7333	-2680	-4602	-3245	1400
Scn1b	1528	1303	6417	-1788	-2293
Scn2a	-5260	-7319	-4977	-7005	2190
Scn2b	-1576	1395	1773	-4585	5442
Scn3a	-5313	-2975	-672	-5460	2994
Scn3b	-6378	3555	5590	6924	1964
Scn4b	-7305	-1547	844	-2757	3044
Scn5a	2525	3649	4823	-714	5676
Scn7a	1352	-6596	-5156	4645	3505
Scn8a	-7468	-30	5464	-7566	7318
Scn9a	1795	-1657	-3383	-5341	4759
Sptan1	-840	555	4805	581	5999
Sptb	-566	2032	6354	-2427	6126
Sptbn1	-1023	1954	1990	-776	5862
Sptbn2	-1927	1956	7367	-2128	5981
Sptbn4	4477	7367	8168	-3088	8065
Sptbn5	2976	3892	-3141	979	7554

---

---

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS

metric	value
setSize	11
pMANOVA	0.00486
p.adjustMANOVA	0.0176
s.dist	0.673
s.hyp	0.0201
s.amy	0.215
s.hip	0.421
s.pag	0.385
s.ni	0.284
p.hyp	0.908
p.amy	0.216
p.hip	0.0156
p.pag	0.0271
p.ni	0.103

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Top 20 genes

Gene	hip	pag
Banp	7823	7407
Ppp1r13b	7533	7230
Trp73	7026	7285
Ppp1r13l	6346	3782
Akt1	6565	2677
Trp53	5027	3493
Zfp385a	6094	2337

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Akt1	6360	2344	6565	2677	398
Akt2	241	1467	2121	-798	2650
Akt3	-6390	-7033	-1729	-507	867
Banp	7743	7465	7823	7407	7692
Phf20	-1898	-1595	-3977	1030	-196
Ppp1r13b	4185	5944	7533	7230	7306
Ppp1r13l	5378	-3689	6346	3782	4509
Trp53	1105	-447	5027	3493	2676
Trp53bp2	-4406	2726	-2634	-1333	-678
Trp73	-5232	1176	7026	7285	296
Zfp385a	-6684	6264	6094	2337	895

---

---

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

metric	value
setSize	20
pMANOVA	0.00575
p.adjustMANOVA	0.02
s.dist	0.669
s.hyp	0.309
s.amy	0.179
s.hip	0.288
s.pag	0.235
s.ni	0.426
p.hyp	0.0166
p.amy	0.166
p.hip	0.0257
p.pag	0.0693
p.ni	0.00097

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Top 20 genes

Gene	ni	hyp
Sdc4	7053	7439
Gpc4	6060	6446
Bcan	6480	5492
Gpc2	7150	3929
Sdc3	3902	4152
Bgn	3570	4178
Gpc3	4714	2897
Agrn	6888	1861
B4galt7	2659	3197
Gpc1	3847	1882
Gpc6	1124	5520

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Agrn	1861	5081	6980	-2088	6888
B4galt7	3197	0	2962	5553	2659
Bcan	5492	7048	7477	4458	6480
Bgn	4178	7435	5050	6132	3570
Cspg4	-1587	1527	6060	4602	7500
Cspg5	6016	-2553	1801	4302	-530
Dcn	-131	-4509	-5217	-2119	214
Gpc1	1882	-106	6929	137	3847
Gpc2	3929	4797	3882	-5872	7150
Gpc3	2897	1571	-2078	6894	4714
Gpc4	6446	-5411	6688	1734	6060
Gpc5	-14	1982	-4174	4061	-289
Gpc6	5520	-2319	2298	-3505	1124
Hspg2	-1278	2548	7040	-7745	3882
Ncan	-2363	3716	5418	-3036	7230
Sdc1	5421	-4340	-1296	2654	-55
Sdc2	-2984	-3295	-7091	2665	-4310
Sdc3	4152	-1359	5367	3173	3902
Sdc4	7439	6843	3217	7101	7053
Vcan	-3348	2114	639	6252	3564

---

---

COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN

metric	value
setSize	10
pMANOVA	0.0099
p.adjustMANOVA	0.0321
s.dist	0.667
s.hyp	-0.342
s.amy	0.102
s.hip	-0.524
s.pag	-0.182
s.ni	-0.0972
p.hyp	0.0609
p.amy	0.577
p.hip	0.00412
p.pag	0.319
p.ni	0.594

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	hyp
Rad21	-7192	-6086
Stag2	-7038	-5620
Smc3	-7435	-4864
Stag1	-3767	-6565
Pds5b	-5817	-3455
Wapl	-5360	-3624
Pds5a	-2948	-2715
Nipbl	-4398	-1662

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Mau2	5121	6689	8229	-3381	7633
Nipbl	-1662	3961	-4398	-5265	5958
Pds5a	-2715	3274	-2948	11	-1256
Pds5b	-3455	-1872	-5817	5160	-5637
Rad21	-6086	-2813	-7192	5423	-6262
Smc1a	1015	4022	-2868	1094	2377
Smc3	-4864	3642	-7435	-7471	63
Stag1	-6565	-428	-3767	-3813	-929
Stag2	-5620	-5078	-7038	-886	-4757
Wapl	-3624	-7120	-5360	-6330	-3463

---

---

NF KB IS ACTIVATED AND SIGNALS SURVIVAL

NF KB IS ACTIVATED AND SIGNALS SURVIVAL

metric	value
setSize	12
pMANOVA	0.134
p.adjustMANOVA	0.236
s.dist	0.666
s.hyp	0.327
s.amy	0.44
s.hip	0.276
s.pag	-0.0869
s.ni	0.243
p.hyp	0.0497
p.amy	0.00827
p.hip	0.0974
p.pag	0.602
p.ni	0.144

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hyp
Ikbkb	6234	4515
Irak1	5999	4581
Nfkb1	6218	3360
Ubb	2477	6745
Uba52	3663	4278
Rps27a	5544	2369
Ubc	2921	2439
Sqstm1	697	6949
Nfkbia	2004	910
Rela	28	5057

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ikbkb	4515	6234	7265	-2790	7903
Irak1	4581	5999	5776	-5371	4578
Nfkb1	3360	6218	3740	-520	4855
Nfkbia	910	2004	-95	-983	-849
Ngfr	-6208	5249	-1151	-1902	4283
Rela	5057	28	7247	-2443	6256
Rps27a	2369	5544	-3760	-441	-3743
Sqstm1	6949	697	1624	6307	-1441
Traf6	-5243	-3617	-1653	584	667
Uba52	4278	3663	1163	-7268	3245
Ubb	6745	2477	5261	1194	-3834
Ubc	2439	2921	4638	4180	3064

---

---

BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM

metric	value
setSize	23
pMANOVA	1.86e-05
p.adjustMANOVA	0.000136
s.dist	0.661
s.hyp	0.169
s.amy	0.116
s.hip	-0.208
s.pag	0.517
s.ni	-0.289
p.hyp	0.161
p.amy	0.335
p.hip	0.0838
p.pag	1.75e-05
p.ni	0.0165

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	ni
Arl6	6530	-7449
Lztfl1	6077	-7434
Tcp1	6208	-6816
Cct4	5832	-6864
Bbs10	7385	-5279
Cct5	6862	-5371
Cct8	6059	-5003
Rab3ip	5805	-5082
Mkks	7525	-3853
Cct2	3553	-6410
Cct3	6697	-2600
Bbip1	1699	-6629
Mchr1	6796	-940
Bbs4	1527	-2581

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Arl6	-4547	-3637	-6472	6530	-7449
Bbip1	-2831	-3900	-5756	1699	-6629
Bbs1	1966	4813	5784	5525	7040
Bbs10	-4633	2331	-4283	7385	-5279
Bbs12	162	4431	-2829	-5215	-4495
Bbs2	2941	3702	4321	1999	6078
Bbs4	-2802	2093	-2050	1527	-2581
Bbs5	-3820	-7147	-6006	-5139	-5879
Bbs7	4223	7101	-673	4196	4005
Bbs9	6455	940	-289	6777	7024
Cct2	580	-1970	-5948	3553	-6410
Cct3	6694	2898	-655	6697	-2600
Cct4	3517	41	-6870	5832	-6864
Cct5	7361	1555	1984	6862	-5371
Cct8	-2035	-5	-7370	6059	-5003
Lztfl1	-5091	-7630	-7153	6077	-7434
Mchr1	496	-3312	207	6796	-940
Mkks	3612	7059	-66	7525	-3853
Rab3ip	5761	594	4126	5805	-5082
Smo	5037	3611	7378	4698	2740
Sstr3	4416	-3279	6115	-4848	4314
Tcp1	-2955	-5259	-7116	6208	-6816
Ttc8	3495	7387	2606	5759	2058

---

---

NITRIC OXIDE STIMULATES GUANYLATE CYCLASE

NITRIC OXIDE STIMULATES GUANYLATE CYCLASE

metric	value
setSize	20
pMANOVA	0.000512
p.adjustMANOVA	0.00261
s.dist	0.658
s.hyp	-0.513
s.amy	-0.272
s.hip	-0.196
s.pag	-0.225
s.ni	0.0842
p.hyp	7.09e-05
p.amy	0.0355
p.hip	0.129
p.pag	0.0817
p.ni	0.514

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	amy
Pde1a	-7443	-8246
Gucy1a1	-8026	-6391
Kcnma1	-6805	-7234
Gucy1b1	-6440	-5315
Prkg1	-4724	-6308
Pde2a	-6949	-3513
Itpr1	-6908	-3530
Gucy1a2	-5176	-3783
Pde10a	-7599	-2103
Pde11a	-3618	-4006
Pde5a	-6280	-1789
Kcnmb4	-3554	-2729

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Gucy1a1	-8026	-6391	-6702	-5690	-4551
Gucy1a2	-5176	-3783	292	-7690	6940
Gucy1b1	-6440	-5315	-6157	6562	-2795
Irag1	-1149	1924	1960	-2081	4566
Itpr1	-6908	-3530	-770	-5932	800
Kcnma1	-6805	-7234	-5595	-4828	4858
Kcnmb1	4222	-5485	-5386	1785	3213
Kcnmb2	-8067	1486	-4902	-2598	-5837
Kcnmb4	-3554	-2729	1374	-2457	-7330
Nos1	2589	-1178	2289	-4747	4498
Nos3	1599	7551	7663	4077	7877
Pde10a	-7599	-2103	2753	-4237	4195
Pde11a	-3618	-4006	-1822	-6517	4844
Pde1a	-7443	-8246	-5234	1503	-2833
Pde1b	-7660	303	5425	1396	3843
Pde2a	-6949	-3513	5284	526	-759
Pde5a	-6280	-1789	-4561	-5350	-3385
Pde9a	2408	-2780	-711	-467	-2500
Prkg1	-4724	-6308	-4240	-2649	-2494
Prkg2	-4452	2291	-6027	1706	3157

---

---

AGGREPHAGY

AGGREPHAGY

metric	value
setSize	34
pMANOVA	3.96e-05
p.adjustMANOVA	0.000264
s.dist	0.656
s.hyp	0.416
s.amy	0.33
s.hip	0.222
s.pag	0.314
s.ni	0.0265
p.hyp	2.75e-05
p.amy	0.000858
p.hip	0.0251
p.pag	0.00152
p.ni	0.789

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	amy
Hsf1	7668	7451
Tubb4a	6675	7116
Vim	7001	6755
Tubb3	6704	6744
Tubb6	6888	5270
Hdac6	5011	6434
Vcp	5626	4455
Dynll2	3756	6487
Tuba1b	7288	3200
Park7	4310	4304
Ubb	6745	2477
Uba52	4278	3663
Tuba4a	4780	2823
Rps27a	2369	5544
Tubb4b	7429	1201
Dync1h1	2189	3973
Ubc	2439	2921
Tubb2a	7422	937
Tubb2b	5998	573
Dync1i1	5931	545

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Arl13b	-3315	1632	-5087	2289	-1893
Dync1h1	2189	3973	6224	1230	7915
Dync1i1	5931	545	1970	5364	-1606
Dync1i2	-3741	-2334	-5530	-3547	-5951
Dync1li1	2087	1167	-1863	2438	-320
Dync1li2	-4070	-2855	-4877	-3224	3273
Dynll1	1915	-2057	-36	3348	-3628
Dynll2	3756	6487	2101	-1717	6879
Hdac6	5011	6434	7777	-3719	7955
Hsf1	7668	7451	8166	6743	7567
Hsp90aa1	-7085	-5028	-7549	-2713	-6656
Ift88	5176	259	-4275	7701	3872
Park7	4310	4304	-889	-1310	-2266
Pcnt	-3308	2494	6059	-6986	4118
Prkn	-1337	7157	1855	-3410	4932
Rps27a	2369	5544	-3760	-441	-3743
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875
Uba52	4278	3663	1163	-7268	3245
Ubb	6745	2477	5261	1194	-3834
Ubc	2439	2921	4638	4180	3064
Ube2n	-6655	-5867	-7434	6360	-7240
Ube2v1	3388	-73	154	5459	-2695
Vcp	5626	4455	-2392	6939	1497
Vim	7001	6755	5459	6827	6911

---

---

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

metric	value
setSize	19
pMANOVA	0.0108
p.adjustMANOVA	0.0346
s.dist	0.652
s.hyp	-0.0759
s.amy	-0.228
s.hip	-0.314
s.pag	0.311
s.ni	-0.414
p.hyp	0.567
p.amy	0.0856
p.hip	0.0179
p.pag	0.0188
p.ni	0.00178

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	ni	hip
P2ry12	-7424	-6698
Gnai3	-6258	-6403
Gng2	-5776	-6826
Gng10	-7069	-5148
Gnai1	-5916	-6131
Gng11	-6409	-5245
Gnb4	-5321	-5409
Gng12	-2905	-6142
Gng5	-2493	-3713
Gnb1	-642	-4732
Gng3	-2063	-914

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Gnai1	-2589	-8320	-6131	4519	-5916
Gnai2	5779	-1103	4440	5327	-2019
Gnai3	-4784	-4807	-6403	5503	-6258
Gnb1	-3399	-6374	-4732	5929	-642
Gnb2	5207	-168	6373	3159	-3241
Gnb4	-6591	-7713	-5409	-2508	-5321
Gnb5	-2382	2240	1479	4186	-4203
Gng10	-630	-5352	-5148	305	-7069
Gng11	-2462	-345	-5245	-6387	-6409
Gng12	-4466	-6055	-6142	7562	-2905
Gng13	3044	-3521	820	-5937	-1764
Gng2	-4701	-7636	-6826	7413	-5776
Gng3	3150	4489	-914	1336	-2063
Gng4	6665	664	-2323	5118	4764
Gng5	2875	-783	-3713	3373	-2493
Gng7	-6296	-389	4195	4360	-1201
Gng8	3848	5583	794	4315	1053
Gngt2	1365	4342	28	-6382	-875
P2ry12	-7431	-6438	-6698	3972	-7424

---

---

RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING

metric	value
setSize	12
pMANOVA	0.0112
p.adjustMANOVA	0.0355
s.dist	0.65
s.hyp	0.232
s.amy	-0.0734
s.hip	0.263
s.pag	0.541
s.ni	0.0343
p.hyp	0.164
p.amy	0.66
p.hip	0.115
p.pag	0.00117
p.ni	0.837

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	hip
Dnm2	7134	8077
Ap2a1	5698	7719
Ap2m1	7301	3921
Dnal4	6913	3602
Ap2a2	6537	2350
Ap2b1	7047	1651
Clta	3299	2029
Dnm1	748	5792

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ap2a1	6184	5021	7719	5698	5641
Ap2a2	3986	-3420	2350	6537	4383
Ap2b1	-2044	-2966	1651	7047	2717
Ap2m1	5631	1351	3921	7301	-2633
Ap2s1	5917	216	4433	-3158	-3443
Clta	6398	-608	2029	3299	-5356
Cltc	-4741	-7132	-5794	4164	-2803
Dnal4	6272	-1105	3602	6913	-287
Dnm1	-111	769	5792	748	2713
Dnm2	5710	7331	8077	7134	7896
Dnm3	-7312	-3791	-3405	2129	-2109
Sh3gl2	-5225	-7270	-1631	2657	-1690

---

---

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

metric	value
setSize	13
pMANOVA	0.0168
p.adjustMANOVA	0.0497
s.dist	0.65
s.hyp	-0.0646
s.amy	-0.139
s.hip	-0.513
s.pag	0.0675
s.ni	-0.361
p.hyp	0.687
p.amy	0.385
p.hip	0.00135
p.pag	0.674
p.ni	0.0243

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Spcs3	-7357	-7246
Spcs2	-7495	-5753
Spcs1	-5111	-5007
Dpp4	-6559	-2218
Sec11c	-3318	-4204
Tcf7l2	-2595	-4998
Pax6	-1638	-5784
Grp	-1185	-3872
Pcsk1	-6742	-662
Sec11a	-3336	-531

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ctnnb1	-2284	-4564	-2053	6367	1314
Dpp4	-3157	-6389	-6559	-6065	-2218
Gng13	3044	-3521	820	-5937	-1764
Grp	5515	-5746	-1185	1232	-3872
Isl1	3663	-269	-2512	4464	5317
Pax6	-7834	-2107	-1638	-6310	-5784
Pcsk1	5418	-1586	-6742	7409	-662
Sec11a	-201	3067	-3336	4439	-531
Sec11c	-955	3945	-3318	-2748	-4204
Spcs1	2401	732	-5111	1559	-5007
Spcs2	-320	-1082	-7495	-58	-5753
Spcs3	-7675	-6722	-7357	4405	-7246
Tcf7l2	-5888	4874	-2595	-3042	-4998

---

---

INTERFERON ALPHA BETA SIGNALING

INTERFERON ALPHA BETA SIGNALING

metric	value
setSize	51
pMANOVA	1.09e-08
p.adjustMANOVA	1.46e-07
s.dist	0.646
s.hyp	-0.214
s.amy	-0.305
s.hip	-0.198
s.pag	-0.39
s.ni	-0.296
p.hyp	0.00812
p.amy	0.000169
p.hip	0.0145
p.pag	1.49e-06
p.ni	0.000257

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	pag	amy
Irf7	-8052	-8340
H2-T23	-8030	-8307
Isg15	-8026	-8303
Usp18	-8041	-8277
Bst2	-7973	-8296
Rsad2	-8029	-8161
Ifit3	-7896	-8051
H2-Q4	-8019	-7772
Oas1a	-8046	-7608
Xaf1	-7825	-7439
Psmb8	-7985	-6999
Stat1	-7192	-7602
Ifnar1	-6191	-7552
Samhd1	-7846	-5626
Irf1	-7638	-5758
H2-D1	-4556	-8096
H2-K1	-7083	-5095
Ifitm3	-7301	-4029
H2-Q7	-6899	-4032
Ifi27	-7858	-3537

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Abce1	-7054	-5761	-7086	7071	-6683
Adar	604	301	4034	994	3980
Bst2	-6286	-8296	-1986	-7973	-6728
Egr1	-1918	-1120	-1678	-4777	-6807
Gbp2	-4470	-8002	-4552	4766	-5778
H2-D1	-4848	-8096	-4486	-4556	-5338
H2-K1	-6728	-5095	-5410	-7083	-5377
H2-M3	-2205	6099	263	-7744	-6340
H2-Q10	2682	-1183	-3329	-6250	640
H2-Q4	-6064	-7772	-5535	-8019	-4911
H2-Q7	-5010	-4032	-2167	-6899	-4157
H2-T22	5071	7086	1153	-4736	-2898
H2-T23	-7160	-8307	-6297	-8030	-7419
Ifi27	744	-3537	-2890	-7858	-4141
Ifi35	2151	-2439	872	-7914	-4606
Ifit1bl1	-4623	-5812	-1989	2279	-1392
Ifit2	-7318	-7500	-7035	542	-2825
Ifit3	-3614	-8051	-6509	-7896	-4988
Ifitm1	6201	7556	6965	4308	7030
Ifitm2	-1443	-3128	5130	16	-378
Ifitm3	-3297	-4029	-2420	-7301	-6208
Ifnar1	-5428	-7552	-2679	-6191	5071
Ifnar2	877	-4863	-4619	-2728	-5868
Ip6k2	7566	1208	7340	7441	1349
Irf1	-4585	-5758	863	-7638	-7263
Irf2	-1949	5212	-805	958	-4554
Irf3	5906	6830	6533	1119	6409
Irf5	-615	3841	5609	-2162	-2239
Irf7	-8080	-8340	-7558	-8052	-7751
Irf8	4468	-478	1689	-2133	956
Irf9	-2175	2257	-785	-4996	-3304
Isg15	-7500	-8303	-6370	-8026	-7284
Jak1	-3413	-8209	-2854	2067	-637
Kpna1	-5874	-6802	-7087	4786	-6347
Kpnb1	-1782	-1081	-1660	2868	2606
Mx2	-949	-1172	-612	-7759	-46
Oas1a	-6423	-7608	-5472	-8046	-5762
Psmb8	-6400	-6999	-3086	-7985	-5667
Ptpn1	3912	3983	7209	-2086	32
Ptpn11	4221	4122	5779	3491	6531
Ptpn6	1708	7242	2413	243	641
Rnasel	-7553	365	-3702	-6828	4787
Rsad2	-6772	-8161	-6264	-8029	-7210
Samhd1	-4743	-5626	-3325	-7846	-2299
Socs1	7617	-7845	-2248	4896	6533
Socs3	6204	-6940	2848	1707	1813
Stat1	-3713	-7602	-4216	-7192	-5040
Stat2	4326	6069	6289	-3340	4618
Tyk2	5759	6304	7500	1849	6733
Usp18	-6112	-8277	-6203	-8041	-6746
Xaf1	-6887	-7439	-3973	-7825	-7005

---

---

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

metric	value
setSize	13
pMANOVA	0.0245
p.adjustMANOVA	0.0664
s.dist	0.638
s.hyp	0.473
s.amy	0.0655
s.hip	0.145
s.pag	0.396
s.ni	0.0286
p.hyp	0.00313
p.amy	0.683
p.hip	0.367
p.pag	0.0134
p.ni	0.858

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	pag
Fzd2	7263	7692
Ap2m1	5631	7301
Fzd5	5769	6251
Ap2a1	6184	5698
Ap2a2	3986	6537
Clta	6398	3299
Cltb	7066	2895
Ror2	855	2937

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ap2a1	6184	5021	7719	5698	5641
Ap2a2	3986	-3420	2350	6537	4383
Ap2b1	-2044	-2966	1651	7047	2717
Ap2m1	5631	1351	3921	7301	-2633
Ap2s1	5917	216	4433	-3158	-3443
Clta	6398	-608	2029	3299	-5356
Cltb	7066	7429	2403	2895	819
Cltc	-4741	-7132	-5794	4164	-2803
Fzd2	7263	7224	6400	7692	7175
Fzd5	5769	-6663	551	6251	6190
Ror1	2657	-3874	-1222	-5889	-6464
Ror2	855	5901	-2274	2937	78
Wnt5a	2378	-685	-3235	-5088	-1445

---

---

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

metric	value
setSize	20
pMANOVA	0.000773
p.adjustMANOVA	0.00368
s.dist	0.637
s.hyp	-0.224
s.amy	-0.0125
s.hip	-0.343
s.pag	0.379
s.ni	-0.307
p.hyp	0.0834
p.amy	0.923
p.hip	0.00801
p.pag	0.00332
p.ni	0.0175

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	pag	hip
Acsl4	7261	-7561
Hsd17b12	7148	-6710
Elovl4	5451	-6914
Hacd3	5482	-6631
Acsl3	3977	-7537
Acsl5	4574	-5035
Hacd2	6088	-3453
Elovl5	2447	-5581
Acsl6	5640	-2421
Elovl2	2428	-4915
Acsl1	2525	-2647
Elovl6	2662	-850

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acsbg1	3441	7003	6694	7153	3305
Acsf3	3935	-2585	450	-1653	3380
Acsl1	-6973	-4003	-2647	2525	542
Acsl3	-4973	-3745	-7537	3977	-5600
Acsl4	-5045	-6454	-7561	7261	-4079
Acsl5	-3052	-4785	-5035	4574	-2175
Acsl6	-5736	420	-2421	5640	-1711
Elovl1	3247	7567	7021	7001	-2388
Elovl2	-6518	-855	-4915	2428	-5885
Elovl4	-6049	-6756	-6914	5451	-7518
Elovl5	-5714	390	-5581	2447	-4350
Elovl6	-4173	3483	-850	2662	5326
Elovl7	-7171	-7633	-6498	-7170	-7806
Hacd1	1854	2147	-4671	-7674	-5808
Hacd2	821	-3675	-3453	6088	-2920
Hacd3	-627	3601	-6631	5482	-7517
Hacd4	-1484	-3023	-3004	-3522	-463
Hsd17b12	-5442	-286	-6710	7148	-7323
Slc27a3	7113	2587	8046	1963	2259
Tecr	4537	6955	3914	6570	4878

---

---

THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION

THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION

metric	value
setSize	13
pMANOVA	0.00044
p.adjustMANOVA	0.00233
s.dist	0.636
s.hyp	0.0939
s.amy	-0.376
s.hip	0.0607
s.pag	0.0888
s.ni	-0.493
p.hyp	0.558
p.amy	0.0188
p.hip	0.705
p.pag	0.579
p.ni	0.00211

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	ni	amy
Abca4	-7582	-7669
Ttr	-6840	-6564
Rdh5	-5715	-6788
Cyp4v3	-5999	-4234
Stra6	-7642	-3273
Napepld	-4764	-3477
Rdh10	-2380	-6290

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Abca4	-4461	-7669	1555	-1109	-7582
Cyp4v3	-4824	-4234	-5951	5402	-5999
Myo7a	6836	-2647	5053	5810	2872
Napepld	-1599	-3477	-221	4566	-4764
Rbp1	3773	2564	2199	-733	-3275
Rbp4	3755	-4676	-3046	4701	1966
Rdh10	1430	-6290	-3017	-1195	-2380
Rdh11	1976	885	-3784	4214	-6386
Rdh12	-3100	2640	2392	-7033	-4586
Rdh5	6508	-6788	6697	6005	-5715
Rlbp1	-2826	-4342	-247	1067	1321
Stra6	-5403	-3273	4060	-7582	-7642
Ttr	6044	-6564	4576	-6195	-6840

---

---

EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION

metric	value
setSize	87
pMANOVA	1.53e-38
p.adjustMANOVA	5.91e-36
s.dist	0.636
s.hyp	0.303
s.amy	0.436
s.hip	-0.131
s.pag	-0.191
s.ni	-0.261
p.hyp	1.07e-06
p.amy	2.01e-12
p.hip	0.0347
p.pag	0.00206
p.ni	2.54e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	hyp
Eef1d	6456	6989
Rps28	7194	5451
Rpl26	6971	5134
Rpl38	6273	5561
Rps29	6249	5470
Rps8	7056	4662
Eef2	5830	5415
Rpl8	4909	6167
Rplp2	6259	4670
Rps21	5412	5344
Eef1a2	5942	3822
Rpl37a	5253	4254
Rpl13	3762	5775
Rpl23a	5827	3662
Rps6	3542	6000
Rplp1	4257	4918
Rps9	5298	3862
Rpl7a	4250	4438
Rps19	5114	3478
Fau	3513	5019

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Eef1a1	4084	-2698	-392	5650	-6417
Eef1a2	3822	5942	4633	5909	-622
Eef1b2	5666	2659	-2616	1268	-4215
Eef1d	6989	6456	4607	-1689	1316
Eef1g	916	4417	-4986	-163	-4544
Eef2	5415	5830	5604	5741	4913
Fau	5019	3513	2436	-5249	-1413
Rpl10	4267	3550	2252	7744	6037
Rpl10a	2475	852	931	-5593	4761
Rpl11	1857	2197	-2265	-2043	-4034
Rpl12	3418	3582	3693	-4950	2911
Rpl13	5775	3762	3147	995	159
Rpl13a	-755	392	-2305	-3553	-1657
Rpl14	-683	3805	-3483	-2836	-3835
Rpl15	1254	-3153	-4231	-2060	-4608
Rpl17	-2731	-2558	-2822	-536	-4990
Rpl18	4194	1769	2788	-2026	-3074
Rpl18a	3795	3710	286	1339	-2722
Rpl19	5189	2528	950	-1643	-3442
Rpl21	4849	2862	1074	4521	-4122
Rpl22	-1894	701	-3709	-1568	-4792
Rpl22l1	-3673	-3192	-7063	1822	-6125
Rpl23	2148	5335	-2294	-3877	-1642
Rpl23a	3662	5827	-385	2429	-3716
Rpl24	-1294	4246	-4428	-2880	-4843
Rpl26	5134	6971	-3626	424	2205
Rpl27	3336	512	-251	-2273	-113
Rpl27a	2129	2737	-4407	-616	-3341
Rpl28	670	6743	1611	-5103	1925
Rpl29	-1364	-296	-3910	-3806	-1852
Rpl3	167	2514	-4850	-7309	-519
Rpl30	-6148	3242	-6202	-2010	-67
Rpl31	3404	3092	99	-5867	1590
Rpl32	1819	3799	510	-4768	-2584
Rpl34	1730	-353	2108	-1573	-3915
Rpl35	2924	5929	1123	-5444	-1453
Rpl35a	-2655	4493	-6609	-2642	-3306
Rpl36	5535	2316	4295	-4711	-2221
Rpl36a	3365	883	-3048	-4741	-1241
Rpl36al	4274	2608	1155	-2854	-2781
Rpl37	3062	5239	3586	-4182	1090
Rpl37a	4254	5253	2591	-5827	-1260
Rpl38	5561	6273	3979	-7455	1643
Rpl39	5473	-2306	482	-1629	-3044
Rpl4	2956	831	-2886	2100	-4769
Rpl5	-4983	1229	-6321	-5496	-273
Rpl6	2893	5095	-3991	-1117	-4416
Rpl7	-457	-1282	-3512	569	-5886
Rpl7a	4438	4250	1467	3266	-3745
Rpl8	6167	4909	2664	-812	-1931
Rpl9	463	1417	-2875	342	-4662
Rplp0	2815	-293	-2677	256	-3500
Rplp1	4918	4257	2255	-1201	-1019
Rplp2	4670	6259	3648	-3986	-2013
Rps10	4054	2819	1426	-176	-2579
Rps11	-838	3715	499	-237	-1061
Rps12	3366	1154	3659	-3080	25
Rps13	936	5650	-2778	-2857	-1935
Rps14	2795	2978	-1040	-2658	-1612
Rps15	5041	2865	2773	-3959	-965
Rps15a	5104	-1843	-230	2534	-3203
Rps16	-1429	3233	-1488	-6755	-2323
Rps17	1886	3721	335	553	-2769
Rps18	-5481	4983	-7621	4037	-5349
Rps19	3478	5114	-269	-3455	-2843
Rps2	-5206	5394	-5986	-5113	3509
Rps20	5148	-229	740	-3008	-1639
Rps21	5344	5412	1551	-4021	-1364
Rps23	-59	830	-2279	-5288	-734
Rps24	127	2909	-3751	139	-4126
Rps25	-899	4114	-1656	-3133	-3252
Rps26	522	5240	678	-2099	-2091
Rps27	2968	1582	241	-2565	-2310
Rps27a	2369	5544	-3760	-441	-3743
Rps27l	-3426	4524	-3285	-990	-4328
Rps28	5451	7194	4516	-6398	1510
Rps29	5470	6249	5207	-7076	3683
Rps3	2503	-733	-3035	1463	-3506
Rps3a1	3166	3979	-4293	2365	-5585
Rps4x	-1375	5242	-4056	843	-4817
Rps5	6087	2129	2243	394	-2710
Rps6	6000	3542	-1991	1790	-3479
Rps7	-3599	2590	-6918	3507	-4549
Rps8	4662	7056	-2150	-2818	-41
Rps9	3862	5298	-962	-2798	-2378
Rpsa	5082	2476	1168	162	-1753
Uba52	4278	3663	1163	-7268	3245

---

---

GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES

metric	value
setSize	12
pMANOVA	0.0536
p.adjustMANOVA	0.121
s.dist	0.635
s.hyp	0.412
s.amy	0.179
s.hip	0.102
s.pag	0.436
s.ni	-0.00355
p.hyp	0.0134
p.amy	0.283
p.hip	0.542
p.pag	0.00889
p.ni	0.983

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	pag	hyp
Gaa	7059	7250
G6pc3	6017	6317
Nhlrc1	6493	5035
Gbe1	6844	3759
Ubc	4180	2439
Ppp1r3c	2679	3593
Ubb	1194	6745
Gys1	1738	3873

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Epm2a	-6248	-8250	-5744	4738	-1323
G6pc3	6317	-98	5420	6017	3154
Gaa	7250	438	6772	7059	5285
Gbe1	3759	-3287	-3789	6844	-6622
Gyg	-1552	-871	-3933	7223	-7058
Gys1	3873	7301	7422	1738	7332
Nhlrc1	5035	2483	3997	6493	2960
Ppp1r3c	3593	170	-4060	2679	-1047
Rps27a	2369	5544	-3760	-441	-3743
Uba52	4278	3663	1163	-7268	3245
Ubb	6745	2477	5261	1194	-3834
Ubc	2439	2921	4638	4180	3064

---

---

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

metric	value
setSize	11
pMANOVA	0.0228
p.adjustMANOVA	0.0629
s.dist	0.633
s.hyp	-0.101
s.amy	-0.0461
s.hip	0.294
s.pag	-0.326
s.ni	0.443
p.hyp	0.563
p.amy	0.791
p.hip	0.0911
p.pag	0.0609
p.ni	0.011

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	ni	pag
Cacna1a	5909	-6594
Cacng4	5701	-6613
Cacna1e	6684	-5624
Cacna1b	7319	-4852
Cacna2d2	5110	-4246
Cacng2	2797	-5585
Cacnb2	833	-4547

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cacna1a	4201	3186	7498	-6594	5909
Cacna1b	1564	-1023	5994	-4852	7319
Cacna1e	-3354	-4024	985	-5624	6684
Cacna2d2	-2371	805	2380	-4246	5110
Cacna2d3	-5731	-5202	-65	2787	384
Cacnb1	937	-2945	6196	2472	5418
Cacnb2	-4570	-3448	60	-4547	833
Cacnb3	6674	2262	6897	7739	5886
Cacnb4	-7863	-7030	-7338	-4555	-5716
Cacng2	-3819	6445	294	-5585	2797
Cacng4	4163	2727	6211	-6613	5701

---

---

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

metric	value
setSize	20
pMANOVA	0.000142
p.adjustMANOVA	0.000845
s.dist	0.63
s.hyp	0.342
s.amy	0.0542
s.hip	0.36
s.pag	0.359
s.ni	-0.133
p.hyp	0.00812
p.amy	0.675
p.hip	0.00532
p.pag	0.00541
p.ni	0.302

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	pag
Tubb2a	7381	7623
Tubb4a	7975	7042
Tubb4b	7351	7140
Tuba1b	5658	7377
Tubb3	7362	5443
Tubb2b	5135	7029
Tuba1c	6861	4166
Tuba4a	4171	6754
Tuba1a	4048	6615
Prkab1	2461	5634
Prkag2	2220	5400
Tubb6	6363	1671
Prkag1	2961	1469

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Calm1	-7409	-6439	-7281	419	-6180
Camkk2	-3705	177	4412	-6298	2473
Mapt	5094	6082	5715	-4694	7773
Prkaa1	-5165	-6432	-6345	1424	-6320
Prkaa2	-6815	-7223	-5840	1236	-3679
Prkab1	1554	-5850	2461	5634	-2780
Prkab2	-3891	-5239	1797	-5245	6222
Prkag1	4466	5880	2961	1469	-129
Prkag2	140	-6668	2220	5400	-6374
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875

---

---

RHO GTPASES ACTIVATE IQGAPS

RHO GTPASES ACTIVATE IQGAPS

metric	value
setSize	22
pMANOVA	0.000102
p.adjustMANOVA	0.000635
s.dist	0.626
s.hyp	0.27
s.amy	0.122
s.hip	0.298
s.pag	0.444
s.ni	-0.133
p.hyp	0.0286
p.amy	0.323
p.hip	0.0154
p.pag	0.000311
p.ni	0.279

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	hip
Tubb2a	7623	7381
Tubb4a	7042	7975
Tubb4b	7140	7351
Tuba1b	7377	5658
Men1	5815	7166
Tubb3	5443	7362
Tubb2b	7029	5135
Tuba1c	4166	6861
Tuba4a	6754	4171
Tuba1a	6615	4048
Tubb6	1671	6363
Iqgap2	1985	4170
Ctnna1	7015	832
Actg1	1840	725

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Actb	-6900	-2671	4643	-7405	-2371
Actg1	-2568	-3511	725	1840	-5668
Calm1	-7409	-6439	-7281	419	-6180
Cdc42	-6532	-6427	-7563	3375	-7443
Clip1	-279	924	-741	-4799	4906
Ctnna1	4897	7308	832	7015	3818
Ctnnb1	-2284	-4564	-2053	6367	1314
Iqgap1	-1464	4452	279	-551	7034
Iqgap2	-1682	1538	4170	1985	-2867
Men1	4161	2278	7166	5815	3306
Rac1	-3136	-6715	-4502	5613	-6666
Tuba1a	7304	-1417	4048	6615	-1551
Tuba1b	7288	3200	5658	7377	-4046
Tuba1c	2739	-474	6861	4166	-7351
Tuba4a	4780	2823	4171	6754	-3445
Tuba8	4396	693	955	-5030	-4555
Tubb2a	7422	937	7381	7623	790
Tubb2b	5998	573	5135	7029	3783
Tubb3	6704	6744	7362	5443	438
Tubb4a	6675	7116	7975	7042	4157
Tubb4b	7429	1201	7351	7140	-2381
Tubb6	6888	5270	6363	1671	4875

---

---

KERATAN SULFATE BIOSYNTHESIS

KERATAN SULFATE BIOSYNTHESIS

metric	value
setSize	23
pMANOVA	0.00045
p.adjustMANOVA	0.00235
s.dist	0.626
s.hyp	0.325
s.amy	0.0249
s.hip	0.228
s.pag	0.481
s.ni	-0.0476
p.hyp	0.00702
p.amy	0.836
p.hip	0.0587
p.pag	6.58e-05
p.ni	0.693

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Top 20 genes

Gene	pag	hyp
B4galt4	7626	7089
B4galt2	6604	7557
Prelp	7792	6112
St3gal4	5037	7547
Chst1	5341	5880
St3gal2	4466	6461
B4gat1	7371	3137
Fmod	3724	5558
Lum	3141	5480
B3gnt4	3874	3463
B4galt3	1881	6582
Chst2	6464	1741
Chst5	1368	5854
St3gal3	1735	3523
B4galt5	1508	2669
B3gnt7	2622	244

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acan	-3468	2600	4238	4893	3667
B3gnt2	-396	-3405	-2631	6029	-5636
B3gnt4	3463	-6953	2620	3874	137
B3gnt7	244	-5849	-3248	2622	-1610
B4galt1	-5688	-3632	5751	6752	419
B4galt2	7557	-82	5775	6604	-2465
B4galt3	6582	2912	4144	1881	295
B4galt4	7089	-833	-593	7626	-2314
B4galt5	2669	2972	7782	1508	6612
B4galt6	-3432	-7656	-6043	3884	-5794
B4gat1	3137	-1237	2114	7371	-2199
Chst1	5880	-1046	8043	5341	2219
Chst2	1741	2584	7416	6464	470
Chst5	5854	1207	2758	1368	406
Fmod	5558	6581	977	3724	1928
Lum	5480	-2423	-3572	3141	412
Ogn	-414	6947	-3911	-1759	-1563
Prelp	6112	-1468	3704	7792	785
St3gal1	-1689	-7777	3747	2249	4678
St3gal2	6461	1627	6669	4466	3581
St3gal3	3523	6019	8215	1735	-120
St3gal4	7547	6506	1975	5037	-2330
St3gal6	-7288	-1851	-7244	-6980	-6915

---

---

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

metric	value
setSize	12
pMANOVA	0.033
p.adjustMANOVA	0.083
s.dist	0.623
s.hyp	-0.0414
s.amy	-0.0456
s.hip	-0.452
s.pag	0.222
s.ni	-0.36
p.hyp	0.804
p.amy	0.784
p.hip	0.00666
p.pag	0.183
p.ni	0.0308

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Spcs3	-7357	-7246
Pla2g7	-6777	-7592
Spcs2	-7495	-5753
Bche	-5665	-5980
Spcs1	-5111	-5007
Sec11c	-3318	-4204
Pcsk1	-6742	-662
Sec11a	-3336	-531
Igf1	-6388	-171

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ache	7556	6054	6904	5836	6934
Bche	-7941	-8192	-5665	1915	-5980
Crhr2	6025	-2562	2998	-953	1446
Igf1	-5590	-5434	-6388	-4527	-171
Klf4	3823	6275	2806	5480	-3848
Pcsk1	5418	-1586	-6742	7409	-662
Pla2g7	-7971	-3443	-6777	-2721	-7592
Sec11a	-201	3067	-3336	4439	-531
Sec11c	-955	3945	-3318	-2748	-4204
Spcs1	2401	732	-5111	1559	-5007
Spcs2	-320	-1082	-7495	-58	-5753
Spcs3	-7675	-6722	-7357	4405	-7246

---

---

CYTOSOLIC TRNA AMINOACYLATION

CYTOSOLIC TRNA AMINOACYLATION

metric	value
setSize	24
pMANOVA	6.07e-05
p.adjustMANOVA	0.000396
s.dist	0.62
s.hyp	0.354
s.amy	0.296
s.hip	-0.0172
s.pag	0.386
s.ni	-0.15
p.hyp	0.00271
p.amy	0.012
p.hip	0.884
p.pag	0.00107
p.ni	0.203

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	hyp
Mars1	5884	7276
Aimp2	6952	5799
Yars	6183	5815
Hars	7781	4188
Farsb	6746	4765
Ppa1	6648	4809
Wars	5835	5389
Eef1e1	6255	4684
Qars	3941	5434
Aars	4729	4237
Gars	3561	2374
Kars	2597	2765

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Aars	4237	3084	3282	4729	1854
Aimp1	4437	1302	-5187	-403	-5101
Aimp2	5799	5950	3560	6952	-3384
Cars	6207	5841	5399	-1682	4144
Dars	-6166	-6891	-7510	2874	-7603
Eef1e1	4684	-1190	-6787	6255	-6379
Eprs	-7348	2469	-4000	-2317	5523
Farsa	5841	4389	7401	-2935	4612
Farsb	4765	5959	2465	6746	-1377
Gars	2374	-3131	-2465	3561	-5005
Hars	4188	5897	-1927	7781	-3129
Iars	-1419	3220	4265	4685	4808
Kars	2765	-271	1332	2597	-5119
Lars	-6298	-1538	-3381	875	350
Mars1	7276	5861	7566	5884	5977
Nars	-1184	175	-6067	1748	-3428
Ppa1	4809	3738	-4803	6648	-6569
Qars	5434	-3096	5400	3941	2135
Rars	-11	-2856	-6376	6998	-5195
Sars	975	6268	-1572	-1891	581
Tars	5616	4312	-257	-1213	-6716
Vars	6292	89	7773	-2616	6506
Wars	5389	1658	5311	5835	-476
Yars	5815	6083	664	6183	-2114

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report