Mitch Report

date generated: 2024-06-04

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	hyp	amy	hip	pag	ni
0610009B22Rik	0.0972207	1.8312366	-2.2697336	0.4565576	-1.1332185
0610009E02Rik	1.2632625	-0.1037028	-0.3519839	-0.4069908	-0.3290659
0610009L18Rik	-0.6637497	-0.0756377	-0.9139963	-0.1869110	0.1306738
0610010K14Rik	-0.4536898	0.4176706	-0.1751685	-0.3711485	-0.3126674
0610012G03Rik	0.1223624	0.0087096	0.5678859	-0.3421633	-0.2034285
0610030E20Rik	-0.0456229	-1.6095238	1.4359134	0.0842539	-0.5747514

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	15857
duplicated_genes_present	0
num_profile_genes_in_sets	8073
num_profile_genes_not_in_sets	7784

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets:

Gene set metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	444
num_genesets_included	1160

Genes by sector

hyp	amy	hip	pag	ni	Count
-1	-1	-1	-1	-1	506
1	-1	-1	-1	-1	354
1	0	-1	-1	-1	1
-1	1	-1	-1	-1	489
1	1	-1	-1	-1	828
-1	-1	1	-1	-1	410
1	-1	1	-1	-1	241
-1	1	1	-1	-1	134
1	1	1	-1	-1	133
-1	1	-1	0	-1	1
-1	-1	-1	1	-1	383
1	-1	-1	1	-1	231
-1	1	-1	1	-1	1091
1	1	-1	1	-1	1306
-1	-1	1	1	-1	531
1	-1	1	1	-1	233
-1	1	1	1	-1	302
0	1	1	1	-1	1
1	1	1	1	-1	274
-1	1	-1	1	0	1
-1	-1	-1	-1	1	335
1	-1	-1	-1	1	455
-1	1	-1	-1	1	192
1	1	-1	-1	1	529
-1	-1	1	-1	1	1045
1	-1	1	-1	1	810
-1	1	1	-1	1	179
1	1	1	-1	1	328
-1	-1	-1	1	1	186
1	-1	-1	1	1	167
-1	1	-1	1	1	234
1	1	-1	1	1	541
1	1	0	1	1	1
-1	-1	1	1	1	1300
1	-1	1	1	1	837
-1	1	1	1	1	513
1	1	1	1	1	755

Number of significant gene sets (FDR<0.05)= 415

Gene sets by sector

Gene sets by sector

s.hyp	s.amy	s.hip	s.pag	s.ni	Count
-1	-1	-1	-1	-1	5
-1	1	-1	-1	-1	2
1	1	-1	-1	-1	71
-1	-1	1	-1	-1	11
-1	-1	-1	1	-1	3
-1	1	-1	1	-1	27
1	1	-1	1	-1	83
-1	-1	1	1	-1	14
-1	1	1	1	-1	21
1	1	1	1	-1	3
1	1	-1	-1	1	8
-1	-1	1	-1	1	20
1	-1	1	-1	1	7
-1	1	1	-1	1	1
1	1	1	-1	1	4
-1	-1	-1	1	1	1
-1	1	-1	1	1	8
1	1	-1	1	1	31
-1	-1	1	1	1	33
1	-1	1	1	1	7
-1	1	1	1	1	30
1	1	1	1	1	25

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.hyp	s.amy	s.hip	s.pag	s.ni	p.hyp	p.amy	p.hip	p.pag	p.ni
EUKARYOTIC TRANSLATION ELONGATION	87	2.07e-55	1.20e-52	1.130	0.7590	0.50700	-0.5680	-0.34200	-0.00585	1.57e-34	3.07e-16	5.06e-20	3.56e-08	9.25e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.43e-53	5.54e-51	1.020	0.6790	0.48200	-0.5360	-0.25200	-0.02970	1.16e-33	9.37e-18	1.38e-21	7.46e-06	5.98e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	2.50e-48	5.79e-46	1.020	0.6580	0.45900	-0.5310	-0.34100	-0.03780	2.44e-28	1.37e-14	5.95e-19	1.15e-08	5.27e-01
COMPLEX I BIOGENESIS	56	6.34e-25	4.32e-23	1.020	0.5240	0.52900	-0.4900	-0.32200	-0.36400	1.15e-11	7.61e-12	2.26e-10	3.01e-05	2.46e-06
EUKARYOTIC TRANSLATION INITIATION	114	1.05e-51	3.04e-49	0.987	0.6320	0.46600	-0.5440	-0.23200	-0.08240	1.64e-31	8.36e-18	1.03e-23	1.83e-05	1.29e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	7.27e-07	8.52e-06	0.959	0.5450	0.47600	-0.4190	-0.26600	-0.38800	6.30e-05	4.73e-04	2.09e-03	5.06e-02	4.37e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	3.43e-22	1.99e-20	0.947	0.5880	0.47200	-0.5480	-0.10100	-0.13000	5.23e-15	3.64e-10	3.37e-13	1.79e-01	8.38e-02
RESPIRATORY ELECTRON TRANSPORT	102	2.69e-39	3.12e-37	0.944	0.4630	0.50500	-0.4530	-0.27100	-0.37800	6.13e-16	1.28e-18	2.59e-15	2.25e-06	4.43e-11
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	1.15e-03	5.64e-03	0.941	-0.6280	-0.31100	0.4450	0.09860	0.43200	5.83e-04	8.84e-02	1.48e-02	5.89e-01	1.80e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	3.26e-03	1.31e-02	0.935	0.0865	0.64700	-0.4570	0.02500	-0.48900	6.19e-01	2.02e-04	8.61e-03	8.86e-01	5.01e-03
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	2.34e-45	4.52e-43	0.916	0.4660	0.49700	-0.4330	-0.24200	-0.35900	2.14e-19	7.63e-22	5.78e-17	3.15e-06	4.37e-12
ASPARTATE AND ASPARAGINE METABOLISM	10	1.05e-03	5.22e-03	0.897	-0.3790	0.53500	-0.1920	0.42600	-0.39500	3.81e-02	3.38e-03	2.94e-01	1.97e-02	3.04e-02
SELENOAMINO ACID METABOLISM	107	3.88e-41	5.00e-39	0.895	0.5890	0.41000	-0.4930	-0.20600	-0.02880	5.52e-26	2.36e-13	1.28e-18	2.41e-04	6.07e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	4.84e-04	2.64e-03	0.873	0.0136	-0.39000	0.4430	-0.21300	0.60700	9.23e-01	5.43e-03	1.55e-03	1.29e-01	1.47e-05
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	4.43e-06	4.43e-05	0.851	0.2200	0.48600	-0.4950	0.10900	-0.42800	4.08e-02	5.80e-06	3.95e-06	3.09e-01	6.64e-05
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	10	2.70e-03	1.13e-02	0.843	0.6410	0.09840	0.2450	0.02900	0.47800	4.48e-04	5.90e-01	1.79e-01	8.74e-01	8.86e-03
CRISTAE FORMATION	31	5.00e-08	7.25e-07	0.841	0.3870	0.42300	-0.4350	-0.16000	-0.40600	1.96e-04	4.57e-05	2.73e-05	1.23e-01	9.25e-05
CITRIC ACID CYCLE TCA CYCLE	22	3.86e-05	3.11e-04	0.837	0.0475	0.48800	-0.3250	0.47400	-0.36100	7.00e-01	7.53e-05	8.32e-03	1.19e-04	3.39e-03
NONSENSE MEDIATED DECAY NMD	109	1.59e-37	1.54e-35	0.831	0.5290	0.36400	-0.4410	-0.28900	-0.00924	1.29e-21	5.13e-11	1.86e-15	1.94e-07	8.68e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	15	1.56e-05	1.40e-04	0.820	0.3660	0.47800	0.0413	0.35600	0.42600	1.42e-02	1.34e-03	7.82e-01	1.69e-02	4.25e-03
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	2.76e-04	1.62e-03	0.817	0.0615	0.52900	-0.3600	0.39900	-0.30700	6.34e-01	4.19e-05	5.32e-03	1.99e-03	1.74e-02
MITOCHONDRIAL TRANSLATION	93	1.98e-25	1.43e-23	0.815	0.3630	0.36500	-0.4180	-0.20700	-0.42700	1.46e-09	1.17e-09	3.29e-12	5.52e-04	1.13e-12
BRANCHED CHAIN AMINO ACID CATABOLISM	21	3.84e-05	3.11e-04	0.809	0.4110	0.40500	-0.2790	0.44300	-0.22000	1.12e-03	1.33e-03	2.70e-02	4.36e-04	8.07e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	1.96e-03	8.53e-03	0.804	0.4130	0.46600	-0.0991	0.46900	0.16900	1.33e-02	5.21e-03	5.52e-01	4.87e-03	3.11e-01
CD28 DEPENDENT VAV1 PATHWAY	10	3.57e-02	8.59e-02	0.783	0.1440	0.40000	-0.4980	0.34600	-0.25300	4.29e-01	2.83e-02	6.37e-03	5.79e-02	1.67e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	8.06e-10	1.91e-08	0.783	0.4200	0.38000	-0.4580	-0.01820	-0.28700	8.52e-07	8.29e-06	7.47e-08	8.31e-01	7.66e-04
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	2.22e-02	5.90e-02	0.782	-0.2300	-0.14300	0.5090	0.21600	0.48100	2.07e-01	4.33e-01	5.27e-03	2.38e-01	8.41e-03
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	1.23e-04	8.37e-04	0.780	0.3350	0.53600	-0.4500	0.07920	-0.01710	1.15e-02	5.23e-05	6.83e-04	5.50e-01	8.97e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	4.18e-39	4.41e-37	0.779	0.3360	0.46100	-0.4040	-0.09210	-0.33100	3.29e-14	1.69e-25	6.97e-20	3.74e-02	6.75e-14
REGULATION OF EXPRESSION OF SLITS AND ROBOS	160	2.28e-44	3.30e-42	0.777	0.4760	0.36200	-0.4410	-0.21200	-0.08640	2.99e-25	2.61e-15	6.54e-22	3.63e-06	5.97e-02
CRMPS IN SEMA3A SIGNALING	16	6.14e-03	2.11e-02	0.774	-0.1260	-0.51600	0.4850	-0.09840	0.26900	3.83e-01	3.55e-04	7.87e-04	4.95e-01	6.21e-02
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	1.13e-02	3.46e-02	0.766	-0.0544	0.51700	-0.1980	0.41800	-0.32100	7.44e-01	1.94e-03	2.35e-01	1.21e-02	5.43e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.09e-03	5.38e-03	0.764	0.2880	0.27100	-0.6400	-0.03380	-0.12500	7.23e-02	9.06e-02	6.42e-05	8.33e-01	4.33e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	3.15e-03	1.27e-02	0.760	0.2540	0.21300	-0.6470	-0.05060	-0.21500	1.27e-01	2.01e-01	1.05e-04	7.62e-01	1.97e-01
RHOBTB3 ATPASE CYCLE	10	3.14e-02	7.74e-02	0.757	-0.0796	0.47800	-0.3210	0.44600	-0.19100	6.63e-01	8.86e-03	7.91e-02	1.45e-02	2.95e-01
PROTEIN METHYLATION	17	5.43e-03	1.94e-02	0.754	0.2950	0.44400	-0.4670	0.12900	-0.22400	3.52e-02	1.53e-03	8.67e-04	3.56e-01	1.09e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	7.67e-06	7.18e-05	0.747	0.2230	0.30300	-0.5500	-0.08300	-0.32900	3.19e-02	3.47e-03	1.18e-07	4.24e-01	1.54e-03
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	6.55e-03	2.23e-02	0.741	0.0634	0.46600	-0.5230	0.21500	-0.08530	7.04e-01	5.17e-03	1.69e-03	1.96e-01	6.09e-01
METABOLISM OF POLYAMINES	57	3.23e-10	8.91e-09	0.739	0.3540	0.39100	-0.4290	0.03830	-0.28500	3.78e-06	3.21e-07	2.08e-08	6.17e-01	1.99e-04
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	12	4.34e-03	1.62e-02	0.738	0.4330	0.44400	0.0931	0.35500	0.16100	9.36e-03	7.81e-03	5.77e-01	3.33e-02	3.33e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	7.11e-10	1.81e-08	0.737	0.3490	0.37300	-0.4420	-0.04600	-0.29100	9.37e-06	2.12e-06	1.95e-08	5.59e-01	2.19e-04
TRANSLATION	286	5.25e-62	6.09e-59	0.733	0.4160	0.37200	-0.4190	-0.11600	-0.19300	1.08e-33	2.72e-27	3.25e-34	7.66e-04	2.00e-08
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	7.21e-10	1.81e-08	0.730	0.3660	0.35700	-0.4340	-0.08540	-0.27400	4.08e-06	6.78e-06	4.60e-08	2.83e-01	5.56e-04
PHASE 2 PLATEAU PHASE	10	2.53e-02	6.54e-02	0.726	-0.1630	-0.09540	0.3970	-0.06820	0.57400	3.73e-01	6.01e-01	2.99e-02	7.09e-01	1.66e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	58	3.17e-10	8.91e-09	0.717	0.3500	0.38900	-0.4430	0.04860	-0.20400	4.15e-06	3.06e-07	5.39e-09	5.22e-01	7.20e-03
APOPTOSIS INDUCED DNA FRAGMENTATION	10	3.17e-02	7.79e-02	0.717	-0.2360	0.00957	-0.4770	-0.29000	-0.38300	1.96e-01	9.58e-01	9.07e-03	1.13e-01	3.61e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	3.20e-04	1.85e-03	0.712	-0.2910	-0.34800	0.3950	-0.12000	0.36200	8.79e-03	1.73e-03	3.87e-04	2.80e-01	1.14e-03
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	1.38e-02	4.05e-02	0.709	-0.5540	-0.24600	-0.0696	0.15500	-0.32700	2.43e-03	1.77e-01	7.03e-01	3.95e-01	7.35e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	1.07e-02	3.31e-02	0.707	0.4770	0.42300	-0.3000	-0.00586	0.05740	2.91e-03	8.23e-03	6.14e-02	9.71e-01	7.20e-01
GLYCOGEN SYNTHESIS	14	1.76e-02	4.94e-02	0.707	0.1980	0.46200	-0.4220	0.23400	-0.11600	1.99e-01	2.77e-03	6.21e-03	1.30e-01	4.51e-01

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Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.hyp	s.amy	s.hip	s.pag	s.ni	p.hyp	p.amy	p.hip	p.pag	p.ni
EUKARYOTIC TRANSLATION ELONGATION	87	2.07e-55	1.20e-52	1.1300	7.59e-01	0.507000	-0.568000	-0.342000	-0.005850	1.57e-34	3.07e-16	5.06e-20	3.56e-08	9.25e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.43e-53	5.54e-51	1.0200	6.79e-01	0.482000	-0.536000	-0.252000	-0.029700	1.16e-33	9.37e-18	1.38e-21	7.46e-06	5.98e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	2.50e-48	5.79e-46	1.0200	6.58e-01	0.459000	-0.531000	-0.341000	-0.037800	2.44e-28	1.37e-14	5.95e-19	1.15e-08	5.27e-01
COMPLEX I BIOGENESIS	56	6.34e-25	4.32e-23	1.0200	5.24e-01	0.529000	-0.490000	-0.322000	-0.364000	1.15e-11	7.61e-12	2.26e-10	3.01e-05	2.46e-06
EUKARYOTIC TRANSLATION INITIATION	114	1.05e-51	3.04e-49	0.9870	6.32e-01	0.466000	-0.544000	-0.232000	-0.082400	1.64e-31	8.36e-18	1.03e-23	1.83e-05	1.29e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	7.27e-07	8.52e-06	0.9590	5.45e-01	0.476000	-0.419000	-0.266000	-0.388000	6.30e-05	4.73e-04	2.09e-03	5.06e-02	4.37e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	3.43e-22	1.99e-20	0.9470	5.88e-01	0.472000	-0.548000	-0.101000	-0.130000	5.23e-15	3.64e-10	3.37e-13	1.79e-01	8.38e-02
RESPIRATORY ELECTRON TRANSPORT	102	2.69e-39	3.12e-37	0.9440	4.63e-01	0.505000	-0.453000	-0.271000	-0.378000	6.13e-16	1.28e-18	2.59e-15	2.25e-06	4.43e-11
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	1.15e-03	5.64e-03	0.9410	-6.28e-01	-0.311000	0.445000	0.098600	0.432000	5.83e-04	8.84e-02	1.48e-02	5.89e-01	1.80e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	3.26e-03	1.31e-02	0.9350	8.65e-02	0.647000	-0.457000	0.025000	-0.489000	6.19e-01	2.02e-04	8.61e-03	8.86e-01	5.01e-03
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	2.34e-45	4.52e-43	0.9160	4.66e-01	0.497000	-0.433000	-0.242000	-0.359000	2.14e-19	7.63e-22	5.78e-17	3.15e-06	4.37e-12
ASPARTATE AND ASPARAGINE METABOLISM	10	1.05e-03	5.22e-03	0.8970	-3.79e-01	0.535000	-0.192000	0.426000	-0.395000	3.81e-02	3.38e-03	2.94e-01	1.97e-02	3.04e-02
SELENOAMINO ACID METABOLISM	107	3.88e-41	5.00e-39	0.8950	5.89e-01	0.410000	-0.493000	-0.206000	-0.028800	5.52e-26	2.36e-13	1.28e-18	2.41e-04	6.07e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	4.84e-04	2.64e-03	0.8730	1.36e-02	-0.390000	0.443000	-0.213000	0.607000	9.23e-01	5.43e-03	1.55e-03	1.29e-01	1.47e-05
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	4.43e-06	4.43e-05	0.8510	2.20e-01	0.486000	-0.495000	0.109000	-0.428000	4.08e-02	5.80e-06	3.95e-06	3.09e-01	6.64e-05
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	10	2.70e-03	1.13e-02	0.8430	6.41e-01	0.098400	0.245000	0.029000	0.478000	4.48e-04	5.90e-01	1.79e-01	8.74e-01	8.86e-03
CRISTAE FORMATION	31	5.00e-08	7.25e-07	0.8410	3.87e-01	0.423000	-0.435000	-0.160000	-0.406000	1.96e-04	4.57e-05	2.73e-05	1.23e-01	9.25e-05
CITRIC ACID CYCLE TCA CYCLE	22	3.86e-05	3.11e-04	0.8370	4.75e-02	0.488000	-0.325000	0.474000	-0.361000	7.00e-01	7.53e-05	8.32e-03	1.19e-04	3.39e-03
NONSENSE MEDIATED DECAY NMD	109	1.59e-37	1.54e-35	0.8310	5.29e-01	0.364000	-0.441000	-0.289000	-0.009240	1.29e-21	5.13e-11	1.86e-15	1.94e-07	8.68e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	15	1.56e-05	1.40e-04	0.8200	3.66e-01	0.478000	0.041300	0.356000	0.426000	1.42e-02	1.34e-03	7.82e-01	1.69e-02	4.25e-03
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	2.76e-04	1.62e-03	0.8170	6.15e-02	0.529000	-0.360000	0.399000	-0.307000	6.34e-01	4.19e-05	5.32e-03	1.99e-03	1.74e-02
MITOCHONDRIAL TRANSLATION	93	1.98e-25	1.43e-23	0.8150	3.63e-01	0.365000	-0.418000	-0.207000	-0.427000	1.46e-09	1.17e-09	3.29e-12	5.52e-04	1.13e-12
BRANCHED CHAIN AMINO ACID CATABOLISM	21	3.84e-05	3.11e-04	0.8090	4.11e-01	0.405000	-0.279000	0.443000	-0.220000	1.12e-03	1.33e-03	2.70e-02	4.36e-04	8.07e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	1.96e-03	8.53e-03	0.8040	4.13e-01	0.466000	-0.099100	0.469000	0.169000	1.33e-02	5.21e-03	5.52e-01	4.87e-03	3.11e-01
CD28 DEPENDENT VAV1 PATHWAY	10	3.57e-02	8.59e-02	0.7830	1.44e-01	0.400000	-0.498000	0.346000	-0.253000	4.29e-01	2.83e-02	6.37e-03	5.79e-02	1.67e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	8.06e-10	1.91e-08	0.7830	4.20e-01	0.380000	-0.458000	-0.018200	-0.287000	8.52e-07	8.29e-06	7.47e-08	8.31e-01	7.66e-04
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	2.22e-02	5.90e-02	0.7820	-2.30e-01	-0.143000	0.509000	0.216000	0.481000	2.07e-01	4.33e-01	5.27e-03	2.38e-01	8.41e-03
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	1.23e-04	8.37e-04	0.7800	3.35e-01	0.536000	-0.450000	0.079200	-0.017100	1.15e-02	5.23e-05	6.83e-04	5.50e-01	8.97e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	4.18e-39	4.41e-37	0.7790	3.36e-01	0.461000	-0.404000	-0.092100	-0.331000	3.29e-14	1.69e-25	6.97e-20	3.74e-02	6.75e-14
REGULATION OF EXPRESSION OF SLITS AND ROBOS	160	2.28e-44	3.30e-42	0.7770	4.76e-01	0.362000	-0.441000	-0.212000	-0.086400	2.99e-25	2.61e-15	6.54e-22	3.63e-06	5.97e-02
CRMPS IN SEMA3A SIGNALING	16	6.14e-03	2.11e-02	0.7740	-1.26e-01	-0.516000	0.485000	-0.098400	0.269000	3.83e-01	3.55e-04	7.87e-04	4.95e-01	6.21e-02
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	1.13e-02	3.46e-02	0.7660	-5.44e-02	0.517000	-0.198000	0.418000	-0.321000	7.44e-01	1.94e-03	2.35e-01	1.21e-02	5.43e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.09e-03	5.38e-03	0.7640	2.88e-01	0.271000	-0.640000	-0.033800	-0.125000	7.23e-02	9.06e-02	6.42e-05	8.33e-01	4.33e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	3.15e-03	1.27e-02	0.7600	2.54e-01	0.213000	-0.647000	-0.050600	-0.215000	1.27e-01	2.01e-01	1.05e-04	7.62e-01	1.97e-01
RHOBTB3 ATPASE CYCLE	10	3.14e-02	7.74e-02	0.7570	-7.96e-02	0.478000	-0.321000	0.446000	-0.191000	6.63e-01	8.86e-03	7.91e-02	1.45e-02	2.95e-01
PROTEIN METHYLATION	17	5.43e-03	1.94e-02	0.7540	2.95e-01	0.444000	-0.467000	0.129000	-0.224000	3.52e-02	1.53e-03	8.67e-04	3.56e-01	1.09e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	7.67e-06	7.18e-05	0.7470	2.23e-01	0.303000	-0.550000	-0.083000	-0.329000	3.19e-02	3.47e-03	1.18e-07	4.24e-01	1.54e-03
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	6.55e-03	2.23e-02	0.7410	6.34e-02	0.466000	-0.523000	0.215000	-0.085300	7.04e-01	5.17e-03	1.69e-03	1.96e-01	6.09e-01
METABOLISM OF POLYAMINES	57	3.23e-10	8.91e-09	0.7390	3.54e-01	0.391000	-0.429000	0.038300	-0.285000	3.78e-06	3.21e-07	2.08e-08	6.17e-01	1.99e-04
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	12	4.34e-03	1.62e-02	0.7380	4.33e-01	0.444000	0.093100	0.355000	0.161000	9.36e-03	7.81e-03	5.77e-01	3.33e-02	3.33e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	7.11e-10	1.81e-08	0.7370	3.49e-01	0.373000	-0.442000	-0.046000	-0.291000	9.37e-06	2.12e-06	1.95e-08	5.59e-01	2.19e-04
TRANSLATION	286	5.25e-62	6.09e-59	0.7330	4.16e-01	0.372000	-0.419000	-0.116000	-0.193000	1.08e-33	2.72e-27	3.25e-34	7.66e-04	2.00e-08
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	7.21e-10	1.81e-08	0.7300	3.66e-01	0.357000	-0.434000	-0.085400	-0.274000	4.08e-06	6.78e-06	4.60e-08	2.83e-01	5.56e-04
PHASE 2 PLATEAU PHASE	10	2.53e-02	6.54e-02	0.7260	-1.63e-01	-0.095400	0.397000	-0.068200	0.574000	3.73e-01	6.01e-01	2.99e-02	7.09e-01	1.66e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	58	3.17e-10	8.91e-09	0.7170	3.50e-01	0.389000	-0.443000	0.048600	-0.204000	4.15e-06	3.06e-07	5.39e-09	5.22e-01	7.20e-03
APOPTOSIS INDUCED DNA FRAGMENTATION	10	3.17e-02	7.79e-02	0.7170	-2.36e-01	0.009570	-0.477000	-0.290000	-0.383000	1.96e-01	9.58e-01	9.07e-03	1.13e-01	3.61e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	3.20e-04	1.85e-03	0.7120	-2.91e-01	-0.348000	0.395000	-0.120000	0.362000	8.79e-03	1.73e-03	3.87e-04	2.80e-01	1.14e-03
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	1.38e-02	4.05e-02	0.7090	-5.54e-01	-0.246000	-0.069600	0.155000	-0.327000	2.43e-03	1.77e-01	7.03e-01	3.95e-01	7.35e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	1.07e-02	3.31e-02	0.7070	4.77e-01	0.423000	-0.300000	-0.005860	0.057400	2.91e-03	8.23e-03	6.14e-02	9.71e-01	7.20e-01
GLYCOGEN SYNTHESIS	14	1.76e-02	4.94e-02	0.7070	1.98e-01	0.462000	-0.422000	0.234000	-0.116000	1.99e-01	2.77e-03	6.21e-03	1.30e-01	4.51e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	8.96e-04	4.52e-03	0.7060	3.36e-01	0.465000	-0.391000	-0.106000	0.074900	2.01e-02	1.28e-03	6.72e-03	4.65e-01	6.04e-01
STABILIZATION OF P53	54	3.43e-09	6.99e-08	0.7000	3.67e-01	0.339000	-0.407000	-0.050800	-0.267000	3.04e-06	1.66e-05	2.28e-07	5.19e-01	6.93e-04
TRIGLYCERIDE CATABOLISM	14	8.24e-03	2.71e-02	0.6990	1.34e-01	0.519000	-0.437000	0.085300	-0.061200	3.84e-01	7.73e-04	4.68e-03	5.80e-01	6.92e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	7.34e-10	1.81e-08	0.6990	3.26e-01	0.324000	-0.433000	-0.058700	-0.294000	1.52e-05	1.64e-05	9.14e-09	4.36e-01	9.28e-05
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	31	6.16e-06	5.98e-05	0.6980	4.05e-01	0.404000	-0.363000	-0.141000	-0.089100	9.36e-05	9.92e-05	4.63e-04	1.76e-01	3.91e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	8.95e-03	2.88e-02	0.6950	2.86e-01	0.547000	-0.059700	0.313000	-0.014800	7.45e-02	6.35e-04	7.09e-01	5.06e-02	9.27e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	1.26e-03	6.07e-03	0.6920	2.75e-01	0.512000	-0.344000	0.031300	-0.149000	2.56e-02	3.26e-05	5.26e-03	7.99e-01	2.26e-01
G BETA GAMMA SIGNALLING THROUGH CDC42	18	4.21e-03	1.60e-02	0.6880	3.13e-01	0.450000	-0.408000	-0.001840	-0.079900	2.14e-02	9.52e-04	2.70e-03	9.89e-01	5.57e-01
NCAM1 INTERACTIONS	38	1.03e-07	1.32e-06	0.6850	-2.72e-01	-0.280000	0.393000	-0.360000	0.180000	3.68e-03	2.84e-03	2.75e-05	1.21e-04	5.45e-02
CELLULAR RESPONSE TO STARVATION	145	1.17e-30	1.05e-28	0.6820	4.21e-01	0.340000	-0.373000	-0.175000	-0.054600	2.19e-18	1.52e-12	9.57e-15	2.89e-04	2.57e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	1.63e-03	7.34e-03	0.6750	-5.08e-01	-0.290000	0.211000	-0.057900	0.256000	1.90e-04	3.30e-02	1.21e-01	6.70e-01	5.97e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	5.17e-03	1.86e-02	0.6720	2.00e-01	0.259000	-0.327000	0.284000	-0.397000	1.32e-01	5.06e-02	1.36e-02	3.22e-02	2.76e-03
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	8.16e-02	1.61e-01	0.6720	-1.05e-01	-0.318000	0.303000	-0.021900	0.497000	5.46e-01	6.81e-02	8.18e-02	9.00e-01	4.28e-03
LGI ADAM INTERACTIONS	14	1.27e-02	3.78e-02	0.6720	-3.77e-01	-0.227000	0.280000	-0.242000	0.348000	1.47e-02	1.41e-01	6.93e-02	1.17e-01	2.43e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	4.67e-09	8.74e-08	0.6670	3.13e-01	0.351000	-0.380000	0.048800	-0.276000	1.70e-05	1.45e-06	1.77e-07	5.03e-01	1.54e-04
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	9.33e-03	2.98e-02	0.6670	1.03e-02	0.447000	-0.311000	0.193000	-0.332000	9.37e-01	5.32e-04	1.60e-02	1.36e-01	1.01e-02
MITOCHONDRIAL PROTEIN IMPORT	63	2.06e-09	4.59e-08	0.6650	2.78e-01	0.338000	-0.352000	-0.012100	-0.356000	1.34e-04	3.58e-06	1.37e-06	8.68e-01	9.99e-07
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	1.32e-03	6.34e-03	0.6630	2.23e-01	0.271000	-0.411000	0.103000	-0.371000	4.92e-02	1.68e-02	2.85e-04	3.65e-01	1.07e-03
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	6.34e-08	8.89e-07	0.6630	3.32e-01	0.359000	-0.384000	-0.058300	-0.220000	2.95e-05	6.01e-06	1.29e-06	4.63e-01	5.60e-03
CALNEXIN CALRETICULIN CYCLE	26	1.96e-05	1.72e-04	0.6580	1.04e-01	0.398000	-0.236000	0.453000	0.044800	3.59e-01	4.37e-04	3.75e-02	6.39e-05	6.92e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	4.09e-05	3.27e-04	0.6570	4.09e-01	0.296000	-0.369000	0.028000	-0.198000	4.79e-05	3.21e-03	2.46e-04	7.81e-01	4.85e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	2.78e-02	7.00e-02	0.6550	-1.08e-01	0.417000	-0.155000	0.457000	-0.105000	5.18e-01	1.24e-02	3.51e-01	6.11e-03	5.30e-01
DEGRADATION OF DVL	55	3.00e-08	4.64e-07	0.6550	3.37e-01	0.297000	-0.382000	-0.060400	-0.279000	1.57e-05	1.38e-04	9.42e-07	4.39e-01	3.43e-04
CELLULAR RESPONSE TO HYPOXIA	71	5.08e-11	1.59e-09	0.6550	3.68e-01	0.317000	-0.348000	-0.047300	-0.263000	8.44e-08	3.98e-06	3.88e-07	4.91e-01	1.25e-04
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.47e-03	6.78e-03	0.6530	-1.71e-02	-0.271000	0.395000	-0.044000	0.441000	8.76e-01	1.30e-02	2.94e-04	6.87e-01	5.44e-05
ANTIGEN PROCESSING CROSS PRESENTATION	93	1.29e-15	5.53e-14	0.6530	4.14e-01	0.313000	-0.366000	-0.051000	-0.142000	5.42e-12	1.81e-07	1.08e-09	3.95e-01	1.83e-02
ACTIVATION OF SMO	16	1.33e-02	3.92e-02	0.6520	8.89e-02	-0.203000	0.404000	0.284000	0.364000	5.38e-01	1.59e-01	5.16e-03	4.90e-02	1.17e-02
DEGRADATION OF AXIN	53	1.34e-07	1.71e-06	0.6520	3.42e-01	0.334000	-0.374000	-0.018800	-0.239000	1.69e-05	2.67e-05	2.45e-06	8.13e-01	2.66e-03
FATTY ACYL COA BIOSYNTHESIS	32	5.24e-05	3.92e-04	0.6520	5.52e-02	0.470000	-0.268000	0.332000	-0.135000	5.89e-01	4.16e-06	8.72e-03	1.14e-03	1.86e-01
GLUTATHIONE CONJUGATION	29	4.19e-05	3.28e-04	0.6500	4.38e-01	0.382000	-0.167000	0.078000	-0.227000	4.50e-05	3.71e-04	1.19e-01	4.67e-01	3.47e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	1.55e-02	4.49e-02	0.6500	-3.65e-01	0.040400	0.180000	0.469000	-0.185000	3.60e-02	8.17e-01	3.02e-01	7.02e-03	2.88e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	3.70e-07	4.51e-06	0.6490	-2.93e-03	0.385000	-0.336000	0.306000	-0.258000	9.71e-01	2.01e-06	3.38e-05	1.56e-04	1.42e-03
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	59	1.17e-08	1.97e-07	0.6470	3.48e-01	0.329000	-0.341000	-0.039900	-0.269000	3.92e-06	1.24e-05	6.08e-06	5.96e-01	3.45e-04
DEGRADATION OF GLI1 BY THE PROTEASOME	57	8.78e-08	1.20e-06	0.6460	3.11e-01	0.354000	-0.365000	-0.013500	-0.248000	4.81e-05	3.71e-06	1.93e-06	8.60e-01	1.23e-03
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	11	8.81e-04	4.48e-03	0.6440	3.16e-02	0.219000	-0.049100	0.290000	0.528000	8.56e-01	2.09e-01	7.78e-01	9.54e-02	2.41e-03
HEDGEHOG LIGAND BIOGENESIS	61	1.15e-08	1.97e-07	0.6410	3.46e-01	0.348000	-0.372000	0.062700	-0.168000	3.05e-06	2.55e-06	4.99e-07	3.98e-01	2.33e-02
SYNAPTIC ADHESION LIKE MOLECULES	21	1.57e-02	4.51e-02	0.6380	-1.84e-01	-0.315000	0.415000	0.031900	0.317000	1.46e-01	1.24e-02	9.86e-04	8.00e-01	1.18e-02
MET ACTIVATES RAP1 AND RAC1	10	1.55e-01	2.55e-01	0.6370	-1.63e-02	0.322000	-0.222000	0.422000	-0.273000	9.29e-01	7.77e-02	2.24e-01	2.08e-02	1.35e-01
RAS PROCESSING	23	4.27e-03	1.61e-02	0.6360	2.70e-01	0.464000	-0.287000	0.056700	-0.177000	2.50e-02	1.17e-04	1.74e-02	6.38e-01	1.42e-01
ER QUALITY CONTROL COMPARTMENT ERQC	21	3.61e-04	2.03e-03	0.6360	1.65e-02	0.399000	-0.199000	0.451000	0.038700	8.96e-01	1.54e-03	1.14e-01	3.48e-04	7.59e-01
P75NTR REGULATES AXONOGENESIS	10	1.02e-01	1.90e-01	0.6350	-3.31e-01	0.150000	-0.210000	0.219000	-0.423000	6.98e-02	4.11e-01	2.49e-01	2.30e-01	2.06e-02
G PROTEIN ACTIVATION	22	3.23e-05	2.68e-04	0.6330	3.91e-01	0.307000	-0.256000	-0.122000	0.270000	1.49e-03	1.27e-02	3.76e-02	3.23e-01	2.83e-02
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	11	1.78e-02	4.99e-02	0.6330	-2.87e-01	0.078500	0.383000	0.243000	0.326000	9.92e-02	6.52e-01	2.80e-02	1.64e-01	6.13e-02
COLLAGEN CHAIN TRIMERIZATION	37	2.59e-09	5.47e-08	0.6310	-2.07e-01	-0.348000	0.335000	-0.314000	-0.155000	2.95e-02	2.48e-04	4.23e-04	9.65e-04	1.02e-01
INTERLEUKIN 12 SIGNALING	36	1.29e-04	8.68e-04	0.6310	2.32e-01	0.276000	-0.438000	0.007810	-0.276000	1.62e-02	4.15e-03	5.31e-06	9.35e-01	4.23e-03
INTERLEUKIN 6 SIGNALING	10	1.09e-01	2.00e-01	0.6290	3.04e-01	-0.029800	0.353000	0.157000	0.391000	9.55e-02	8.70e-01	5.34e-02	3.91e-01	3.23e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	1.58e-01	2.58e-01	0.6260	3.19e-01	0.452000	-0.225000	0.188000	-0.024600	8.10e-02	1.34e-02	2.18e-01	3.04e-01	8.93e-01
ORC1 REMOVAL FROM CHROMATIN	67	1.93e-08	3.10e-07	0.6240	2.42e-01	0.292000	-0.378000	-0.021900	-0.321000	6.18e-04	3.70e-05	8.99e-08	7.56e-01	5.74e-06
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	2.21e-04	1.35e-03	0.6230	3.87e-01	0.403000	-0.182000	-0.021200	0.204000	1.69e-03	1.05e-03	1.39e-01	8.63e-01	9.81e-02
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	1.37e-02	4.03e-02	0.6210	1.24e-01	0.370000	-0.231000	-0.293000	-0.307000	4.40e-01	2.10e-02	1.49e-01	6.74e-02	5.50e-02
RUNX3 REGULATES NOTCH SIGNALING	13	8.28e-02	1.62e-01	0.6210	-1.18e-01	-0.166000	0.376000	0.043500	0.448000	4.61e-01	3.00e-01	1.88e-02	7.86e-01	5.18e-03
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	1.45e-01	2.44e-01	0.6210	3.14e-01	0.472000	-0.144000	0.192000	-0.081700	8.57e-02	9.80e-03	4.29e-01	2.93e-01	6.55e-01
PENTOSE PHOSPHATE PATHWAY	13	1.67e-01	2.68e-01	0.6190	4.86e-02	0.331000	-0.351000	0.165000	-0.348000	7.62e-01	3.91e-02	2.82e-02	3.02e-01	2.99e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	69	8.02e-09	1.43e-07	0.6180	2.86e-01	0.284000	-0.369000	-0.011700	-0.288000	4.06e-05	4.67e-05	1.12e-07	8.67e-01	3.59e-05
SHC MEDIATED CASCADE FGFR4	10	7.64e-02	1.53e-01	0.6170	1.14e-01	0.507000	-0.294000	-0.115000	-0.104000	5.34e-01	5.47e-03	1.08e-01	5.28e-01	5.69e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	64	8.91e-08	1.20e-06	0.6160	2.44e-01	0.290000	-0.383000	-0.013200	-0.299000	7.45e-04	6.01e-05	1.20e-07	8.55e-01	3.58e-05
INFLUENZA INFECTION	145	8.91e-25	5.74e-23	0.6150	3.64e-01	0.298000	-0.351000	-0.177000	-0.059400	4.14e-14	6.28e-10	3.24e-13	2.35e-04	2.17e-01
FGFR2 LIGAND BINDING AND ACTIVATION	10	6.61e-02	1.38e-01	0.6140	2.07e-02	0.298000	-0.228000	-0.232000	-0.427000	9.10e-01	1.03e-01	2.13e-01	2.04e-01	1.94e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	65	4.78e-08	7.02e-07	0.6110	2.56e-01	0.297000	-0.366000	-0.070100	-0.283000	3.52e-04	3.50e-05	3.29e-07	3.28e-01	8.00e-05
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	29	4.23e-03	1.60e-02	0.6100	-1.42e-01	-0.327000	0.339000	-0.188000	0.309000	1.85e-01	2.33e-03	1.58e-03	8.00e-02	4.02e-03
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	2.14e-06	2.25e-05	0.6100	1.33e-01	0.374000	-0.239000	0.394000	0.055300	1.73e-01	1.30e-04	1.45e-02	5.58e-05	5.72e-01
SIGNALING BY LEPTIN	10	2.11e-01	3.16e-01	0.6090	9.24e-02	-0.132000	0.427000	0.062000	0.399000	6.13e-01	4.69e-01	1.94e-02	7.34e-01	2.90e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES	303	8.41e-45	1.39e-42	0.6090	3.71e-01	0.367000	-0.301000	0.040400	-0.078800	1.20e-28	4.34e-28	2.35e-19	2.28e-01	1.85e-02
G1 S DNA DAMAGE CHECKPOINTS	65	2.32e-08	3.68e-07	0.6080	2.94e-01	0.277000	-0.357000	-0.076400	-0.272000	4.27e-05	1.15e-04	6.35e-07	2.87e-01	1.49e-04
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	4.21e-09	8.00e-08	0.6080	2.57e-01	0.346000	-0.334000	0.034800	-0.266000	8.54e-05	1.28e-07	3.31e-07	5.95e-01	5.04e-05
CS DS DEGRADATION	14	1.26e-02	3.74e-02	0.6060	4.05e-01	0.261000	0.000207	0.144000	0.338000	8.68e-03	9.10e-02	9.99e-01	3.52e-01	2.84e-02
DARPP 32 EVENTS	23	2.07e-04	1.30e-03	0.6060	-2.66e-01	0.437000	-0.181000	0.173000	-0.206000	2.74e-02	2.83e-04	1.33e-01	1.50e-01	8.73e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	12	1.28e-01	2.23e-01	0.6060	-2.05e-01	-0.204000	0.345000	0.039200	0.404000	2.19e-01	2.22e-01	3.83e-02	8.14e-01	1.55e-02
PLATELET SENSITIZATION BY LDL	15	8.39e-03	2.74e-02	0.6020	-8.17e-03	0.497000	-0.050400	0.335000	-0.033200	9.56e-01	8.65e-04	7.35e-01	2.46e-02	8.24e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	2.00e-02	5.46e-02	0.6020	-5.03e-01	0.008940	0.237000	0.091000	0.212000	3.87e-03	9.59e-01	1.73e-01	6.01e-01	2.24e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	1.68e-01	2.69e-01	0.6020	6.46e-02	0.404000	-0.238000	0.302000	-0.216000	6.99e-01	1.54e-02	1.54e-01	6.97e-02	1.95e-01
PYRUVATE METABOLISM	27	2.91e-03	1.21e-02	0.6000	-5.02e-02	0.341000	-0.386000	0.191000	-0.235000	6.52e-01	2.14e-03	5.18e-04	8.55e-02	3.46e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	67	3.09e-08	4.72e-07	0.6000	2.80e-01	0.269000	-0.363000	-0.062400	-0.270000	7.59e-05	1.40e-04	2.71e-07	3.77e-01	1.34e-04
REGULATION OF TLR BY ENDOGENOUS LIGAND	11	2.09e-01	3.14e-01	0.5990	3.09e-01	0.320000	-0.350000	-0.046400	-0.192000	7.63e-02	6.61e-02	4.44e-02	7.90e-01	2.71e-01
CTLA4 INHIBITORY SIGNALING	19	3.47e-03	1.37e-02	0.5980	-1.04e-01	0.403000	-0.088300	0.414000	-0.077200	4.34e-01	2.38e-03	5.05e-01	1.78e-03	5.60e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	5.97e-02	1.27e-01	0.5980	-3.24e-01	-0.094400	0.363000	-0.131000	0.309000	6.26e-02	5.88e-01	3.74e-02	4.53e-01	7.64e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	80	6.62e-10	1.79e-08	0.5980	2.80e-01	0.253000	-0.354000	0.011800	-0.300000	1.51e-05	9.40e-05	4.60e-08	8.55e-01	3.57e-06
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	2.17e-04	1.34e-03	0.5970	2.47e-01	0.383000	-0.364000	0.090700	-0.089800	1.15e-02	8.67e-05	1.95e-04	3.53e-01	3.58e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	5.01e-03	1.83e-02	0.5950	-3.22e-01	0.017900	0.112000	0.442000	-0.205000	2.59e-02	9.02e-01	4.37e-01	2.21e-03	1.56e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	3.96e-03	1.51e-02	0.5950	-2.80e-02	-0.020300	0.361000	-0.012700	0.471000	8.29e-01	8.75e-01	5.23e-03	9.22e-01	2.63e-04
METHYLATION	11	2.47e-01	3.58e-01	0.5940	1.92e-01	0.362000	-0.386000	0.009970	-0.188000	2.71e-01	3.75e-02	2.67e-02	9.54e-01	2.80e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	4.31e-03	1.61e-02	0.5930	1.81e-01	0.282000	-0.171000	0.421000	-0.181000	1.33e-01	1.92e-02	1.57e-01	4.68e-04	1.34e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	6.24e-02	1.31e-01	0.5920	-1.36e-01	-0.174000	0.444000	0.231000	0.227000	3.78e-01	2.59e-01	4.06e-03	1.34e-01	1.41e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	2.86e-01	3.96e-01	0.5920	-5.36e-02	0.211000	-0.411000	-0.079900	-0.357000	7.69e-01	2.48e-01	2.44e-02	6.62e-01	5.07e-02
EARLY PHASE OF HIV LIFE CYCLE	13	1.17e-01	2.10e-01	0.5880	-1.30e-01	0.202000	-0.386000	-0.149000	-0.342000	4.18e-01	2.07e-01	1.59e-02	3.54e-01	3.29e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	1.23e-03	5.97e-03	0.5870	-9.37e-02	-0.048300	0.403000	0.285000	0.299000	4.17e-01	6.76e-01	4.81e-04	1.37e-02	9.77e-03
RECEPTOR MEDIATED MITOPHAGY	11	1.42e-01	2.40e-01	0.5820	-1.59e-01	0.336000	-0.147000	0.323000	-0.274000	3.60e-01	5.36e-02	4.00e-01	6.40e-02	1.16e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	2.24e-03	9.48e-03	0.5810	4.60e-01	0.280000	-0.097000	-0.020300	-0.194000	3.68e-04	3.03e-02	4.53e-01	8.75e-01	1.34e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	2.88e-02	7.17e-02	0.5810	-1.63e-01	0.043100	0.271000	0.338000	0.347000	3.08e-01	7.88e-01	9.02e-02	3.48e-02	3.02e-02
GLUTATHIONE SYNTHESIS AND RECYCLING	11	2.60e-02	6.68e-02	0.5800	3.72e-01	0.323000	0.074400	0.209000	-0.212000	3.27e-02	6.35e-02	6.69e-01	2.30e-01	2.23e-01
FCERI MEDIATED NF KB ACTIVATION	76	1.16e-08	1.97e-07	0.5790	2.86e-01	0.317000	-0.289000	0.002590	-0.263000	1.59e-05	1.75e-06	1.34e-05	9.69e-01	7.58e-05
SIGNAL AMPLIFICATION	30	9.77e-05	6.91e-04	0.5780	3.02e-01	0.415000	-0.169000	0.151000	0.140000	4.24e-03	8.50e-05	1.09e-01	1.53e-01	1.85e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	1.40e-02	4.10e-02	0.5780	-2.34e-01	0.393000	-0.086300	0.296000	-0.172000	1.17e-01	8.34e-03	5.63e-01	4.76e-02	2.49e-01
FRS MEDIATED FGFR4 SIGNALING	12	7.33e-02	1.49e-01	0.5750	1.29e-01	0.509000	-0.224000	0.030300	-0.068100	4.39e-01	2.28e-03	1.79e-01	8.56e-01	6.83e-01
NRAGE SIGNALS DEATH THROUGH JNK	55	2.89e-07	3.60e-06	0.5740	-1.56e-01	-0.173000	0.434000	0.202000	0.213000	4.51e-02	2.62e-02	2.56e-08	9.70e-03	6.28e-03
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	15	4.79e-02	1.09e-01	0.5730	2.76e-01	0.431000	-0.116000	0.229000	0.029100	6.47e-02	3.87e-03	4.36e-01	1.24e-01	8.45e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	2.14e-09	4.60e-08	0.5730	2.05e-01	0.232000	-0.365000	-0.014200	-0.314000	1.01e-03	1.97e-04	5.05e-09	8.20e-01	4.71e-07
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	3.22e-03	1.30e-02	0.5720	-3.60e-02	-0.270000	0.286000	-0.139000	0.390000	7.24e-01	8.29e-03	5.14e-03	1.73e-01	1.32e-04
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	2.04e-01	3.09e-01	0.5720	2.03e-01	0.341000	-0.397000	0.041700	-0.099400	2.44e-01	5.03e-02	2.25e-02	8.11e-01	5.68e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	2.40e-02	6.26e-02	0.5670	-3.07e-01	-0.087500	0.288000	0.365000	0.056000	3.96e-02	5.57e-01	5.35e-02	1.43e-02	7.08e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	1.32e-01	2.28e-01	0.5660	1.10e-01	0.492000	-0.253000	0.035700	-0.012200	5.45e-01	7.04e-03	1.66e-01	8.45e-01	9.47e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	5.81e-02	1.25e-01	0.5650	-3.07e-01	0.335000	-0.267000	0.173000	-0.108000	7.77e-02	5.45e-02	1.25e-01	3.20e-01	5.37e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	15	3.36e-02	8.18e-02	0.5640	-4.15e-01	-0.249000	0.164000	0.052300	0.234000	5.45e-03	9.48e-02	2.71e-01	7.26e-01	1.17e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	31	8.10e-05	5.80e-04	0.5640	-4.22e-01	-0.130000	0.225000	0.268000	0.003930	4.72e-05	2.11e-01	3.02e-02	9.70e-03	9.70e-01
PROTEIN UBIQUITINATION	69	2.26e-06	2.36e-05	0.5640	1.57e-01	0.311000	-0.331000	0.107000	-0.275000	2.43e-02	7.96e-06	1.97e-06	1.24e-01	8.07e-05
SIGNALING BY ROBO RECEPTORS	205	2.98e-29	2.47e-27	0.5620	3.22e-01	0.296000	-0.319000	-0.145000	-0.043500	2.00e-15	2.97e-13	3.44e-15	3.57e-04	2.84e-01
PROCESSING OF SMDT1	16	5.49e-02	1.20e-01	0.5600	8.86e-02	0.118000	-0.426000	0.053200	-0.327000	5.40e-01	4.15e-01	3.15e-03	7.13e-01	2.35e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	9.78e-09	1.72e-07	0.5590	2.76e-01	0.284000	-0.288000	0.092900	-0.255000	1.27e-05	7.11e-06	5.03e-06	1.41e-01	5.47e-05
E2F MEDIATED REGULATION OF DNA REPLICATION	19	3.65e-02	8.73e-02	0.5590	-9.39e-02	0.211000	-0.210000	0.279000	-0.370000	4.79e-01	1.11e-01	1.13e-01	3.52e-02	5.29e-03
COMPLEMENT CASCADE	22	4.37e-03	1.62e-02	0.5560	3.62e-01	0.385000	-0.147000	0.006370	0.093100	3.31e-03	1.76e-03	2.33e-01	9.59e-01	4.50e-01
INTERLEUKIN 12 FAMILY SIGNALING	42	5.03e-04	2.73e-03	0.5560	1.96e-01	0.278000	-0.380000	0.004190	-0.221000	2.78e-02	1.80e-03	2.04e-05	9.63e-01	1.32e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	34	1.54e-03	6.99e-03	0.5550	-2.33e-01	-0.326000	0.305000	-0.203000	0.115000	1.89e-02	9.91e-04	2.09e-03	4.06e-02	2.44e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	66	1.64e-06	1.79e-05	0.5550	2.75e-01	0.318000	-0.305000	0.029900	-0.193000	1.11e-04	8.17e-06	1.87e-05	6.75e-01	6.61e-03
RRNA PROCESSING	194	1.31e-26	1.02e-24	0.5530	3.21e-01	0.253000	-0.314000	-0.185000	-0.079300	1.34e-14	1.23e-09	4.61e-14	9.64e-06	5.73e-02
PI 3K CASCADE FGFR4	10	9.17e-02	1.76e-01	0.5530	-6.22e-02	0.502000	-0.180000	0.128000	-0.045300	7.33e-01	6.03e-03	3.25e-01	4.83e-01	8.04e-01
DNA REPLICATION PRE INITIATION	79	9.54e-08	1.27e-06	0.5530	2.22e-01	0.254000	-0.327000	0.048900	-0.287000	6.43e-04	9.34e-05	5.27e-07	4.53e-01	1.02e-05
CROSSLINKING OF COLLAGEN FIBRILS	13	7.60e-02	1.53e-01	0.5520	-1.59e-01	-0.266000	0.434000	-0.121000	0.081800	3.22e-01	9.71e-02	6.78e-03	4.51e-01	6.10e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	8.74e-03	2.83e-02	0.5520	2.70e-01	-0.069900	0.170000	0.037200	0.443000	3.64e-02	5.88e-01	1.88e-01	7.73e-01	6.08e-04
PHASE 0 RAPID DEPOLARISATION	28	2.04e-03	8.74e-03	0.5490	-3.92e-01	-0.215000	0.218000	-0.147000	0.180000	3.27e-04	4.87e-02	4.62e-02	1.80e-01	1.00e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	10	2.72e-01	3.82e-01	0.5480	2.15e-01	-0.222000	0.361000	0.021800	0.274000	2.40e-01	2.25e-01	4.81e-02	9.05e-01	1.34e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	1.40e-01	2.37e-01	0.5470	-6.82e-02	-0.014300	0.246000	0.108000	0.471000	7.09e-01	9.38e-01	1.77e-01	5.55e-01	9.89e-03
GLYCOGEN STORAGE DISEASES	12	1.07e-01	1.96e-01	0.5460	1.56e-01	0.447000	-0.188000	0.190000	0.052500	3.49e-01	7.38e-03	2.59e-01	2.54e-01	7.53e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	7.72e-02	1.54e-01	0.5460	3.24e-01	0.314000	-0.275000	0.016000	-0.138000	1.75e-02	2.12e-02	4.32e-02	9.07e-01	3.10e-01
REGULATION OF RAS BY GAPS	66	2.07e-06	2.21e-05	0.5410	2.88e-01	0.274000	-0.310000	0.027200	-0.193000	5.17e-05	1.16e-04	1.31e-05	7.03e-01	6.63e-03
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	2.73e-01	3.82e-01	0.5410	2.57e-02	-0.234000	0.325000	-0.000787	0.363000	8.72e-01	1.44e-01	4.26e-02	9.96e-01	2.36e-02
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	2.25e-01	3.33e-01	0.5400	1.82e-01	0.396000	-0.233000	0.213000	0.042000	3.18e-01	3.01e-02	2.01e-01	2.44e-01	8.18e-01
INTERLEUKIN 37 SIGNALING	17	6.65e-03	2.24e-02	0.5400	9.03e-02	0.161000	0.384000	0.217000	0.250000	5.19e-01	2.51e-01	6.09e-03	1.21e-01	7.39e-02
SHC MEDIATED CASCADE FGFR3	12	5.59e-02	1.21e-01	0.5400	9.53e-02	0.488000	-0.183000	-0.074600	-0.072400	5.68e-01	3.43e-03	2.73e-01	6.55e-01	6.64e-01
RORA ACTIVATES GENE EXPRESSION	18	7.09e-02	1.45e-01	0.5380	7.91e-02	-0.123000	0.395000	0.049000	0.332000	5.61e-01	3.67e-01	3.76e-03	7.19e-01	1.49e-02
GLYCOGEN METABOLISM	25	6.10e-03	2.11e-02	0.5370	1.99e-01	0.382000	-0.204000	0.247000	0.026700	8.58e-02	9.49e-04	7.80e-02	3.27e-02	8.17e-01
MITOPHAGY	29	7.18e-03	2.40e-02	0.5360	1.37e-01	0.424000	-0.246000	0.103000	-0.135000	2.02e-01	7.77e-05	2.20e-02	3.35e-01	2.08e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	2.24e-03	9.48e-03	0.5360	-3.11e-01	0.133000	0.185000	0.134000	0.348000	3.15e-02	3.58e-01	2.00e-01	3.53e-01	1.60e-02
INSULIN RECEPTOR RECYCLING	20	9.54e-02	1.80e-01	0.5340	4.92e-02	0.357000	-0.305000	0.121000	-0.219000	7.03e-01	5.78e-03	1.84e-02	3.51e-01	9.05e-02
SUPPRESSION OF PHAGOSOMAL MATURATION	12	2.90e-01	4.00e-01	0.5310	-3.17e-02	0.345000	-0.244000	0.239000	-0.214000	8.49e-01	3.87e-02	1.44e-01	1.51e-01	1.99e-01
IRAK4 DEFICIENCY TLR2 4	12	2.30e-01	3.40e-01	0.5300	2.15e-01	0.298000	-0.370000	-0.015400	-0.091000	1.96e-01	7.35e-02	2.63e-02	9.27e-01	5.85e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	11	1.86e-01	2.88e-01	0.5290	-2.57e-01	0.237000	-0.114000	0.287000	-0.249000	1.39e-01	1.74e-01	5.14e-01	9.92e-02	1.52e-01
PROTEIN LOCALIZATION	156	2.78e-14	1.04e-12	0.5290	2.31e-01	0.307000	-0.253000	0.120000	-0.232000	6.76e-07	3.84e-11	5.27e-08	9.97e-03	5.59e-07
PROCESSING AND ACTIVATION OF SUMO	10	4.55e-01	5.47e-01	0.5280	5.63e-02	0.281000	-0.354000	0.140000	-0.227000	7.58e-01	1.24e-01	5.27e-02	4.42e-01	2.13e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	6.05e-02	1.28e-01	0.5270	-9.79e-02	0.311000	-0.245000	0.325000	-0.077500	5.12e-01	3.70e-02	1.00e-01	2.94e-02	6.03e-01
HDMS DEMETHYLATE HISTONES	26	8.66e-03	2.81e-02	0.5270	-2.84e-01	-0.160000	0.344000	-0.016800	0.230000	1.22e-02	1.58e-01	2.39e-03	8.82e-01	4.27e-02
FRS MEDIATED FGFR3 SIGNALING	14	4.37e-02	1.01e-01	0.5270	1.11e-01	0.492000	-0.139000	0.044500	-0.046100	4.72e-01	1.44e-03	3.68e-01	7.73e-01	7.65e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	1.36e-01	2.34e-01	0.5270	-2.54e-01	-0.133000	0.170000	0.398000	-0.087900	1.64e-01	4.66e-01	3.53e-01	2.92e-02	6.31e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	1.57e-02	4.51e-02	0.5260	-3.65e-01	-0.251000	0.186000	-0.032400	0.212000	2.42e-03	3.71e-02	1.22e-01	7.88e-01	7.92e-02
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	1.03e-03	5.16e-03	0.5260	-4.10e-01	-0.145000	0.217000	0.196000	0.042900	1.34e-04	1.75e-01	4.28e-02	6.78e-02	6.90e-01
CHOLESTEROL BIOSYNTHESIS	24	2.01e-02	5.48e-02	0.5260	-2.16e-02	0.101000	-0.372000	0.041900	-0.354000	8.55e-01	3.92e-01	1.60e-03	7.22e-01	2.65e-03
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	4.91e-03	1.81e-02	0.5260	1.33e-01	-0.115000	0.209000	0.031900	0.448000	2.41e-01	3.11e-01	6.51e-02	7.78e-01	7.71e-05
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	2.94e-03	1.21e-02	0.5250	3.04e-01	0.357000	-0.150000	0.035000	0.180000	1.15e-02	3.08e-03	2.13e-01	7.72e-01	1.34e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	6.61e-02	1.38e-01	0.5240	1.82e-01	0.455000	-0.174000	0.012300	-0.064700	2.22e-01	2.29e-03	2.43e-01	9.34e-01	6.65e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	24	5.13e-03	1.85e-02	0.5240	1.06e-01	-0.071100	0.225000	0.276000	0.362000	3.70e-01	5.47e-01	5.64e-02	1.91e-02	2.14e-03
ENOS ACTIVATION	11	1.63e-01	2.64e-01	0.5240	5.51e-02	0.442000	-0.271000	-0.004230	-0.047600	7.52e-01	1.12e-02	1.19e-01	9.81e-01	7.85e-01
HDR THROUGH MMEJ ALT NHEJ	10	1.87e-01	2.89e-01	0.5210	-4.50e-01	-0.127000	0.014900	0.144000	-0.178000	1.36e-02	4.87e-01	9.35e-01	4.30e-01	3.30e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	3.83e-03	1.48e-02	0.5200	-4.19e-01	-0.157000	-0.122000	-0.046800	-0.230000	3.80e-04	1.83e-01	3.01e-01	6.91e-01	5.10e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	24	3.33e-02	8.14e-02	0.5190	1.53e-01	0.377000	-0.231000	0.205000	-0.089800	1.95e-01	1.39e-03	4.99e-02	8.26e-02	4.47e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	8.44e-02	1.64e-01	0.5190	2.49e-02	0.150000	-0.000728	0.434000	-0.240000	8.77e-01	3.49e-01	9.96e-01	6.74e-03	1.35e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	2.64e-02	6.76e-02	0.5190	8.44e-02	0.304000	-0.292000	0.164000	-0.239000	4.24e-01	3.99e-03	5.59e-03	1.21e-01	2.34e-02
INITIAL TRIGGERING OF COMPLEMENT	10	1.25e-01	2.19e-01	0.5160	3.35e-01	0.331000	0.086600	0.000126	0.192000	6.67e-02	6.98e-02	6.36e-01	9.99e-01	2.92e-01
GLYCOSPHINGOLIPID METABOLISM	38	1.09e-04	7.66e-04	0.5150	2.33e-01	0.214000	-0.039000	0.363000	-0.179000	1.30e-02	2.24e-02	6.77e-01	1.07e-04	5.63e-02
PEROXISOMAL LIPID METABOLISM	26	9.14e-03	2.94e-02	0.5150	2.57e-01	0.252000	-0.096400	0.316000	-0.163000	2.36e-02	2.62e-02	3.95e-01	5.33e-03	1.50e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	9.98e-03	3.14e-02	0.5130	3.22e-01	-0.071700	0.372000	-0.123000	0.034000	4.42e-02	6.55e-01	2.03e-02	4.43e-01	8.32e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	20	5.44e-02	1.19e-01	0.5130	3.66e-01	0.288000	-0.202000	0.058200	-0.043900	4.63e-03	2.56e-02	1.17e-01	6.53e-01	7.34e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	80	7.92e-08	1.09e-06	0.5130	2.82e-01	0.250000	-0.290000	-0.114000	-0.155000	1.27e-05	1.10e-04	7.54e-06	7.88e-02	1.66e-02
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	50	8.96e-04	4.52e-03	0.5130	1.60e-01	0.273000	-0.314000	0.072200	-0.244000	4.99e-02	8.51e-04	1.26e-04	3.78e-01	2.88e-03
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	5.86e-02	1.26e-01	0.5130	8.73e-02	0.313000	-0.275000	0.109000	-0.264000	4.41e-01	5.80e-03	1.51e-02	3.36e-01	1.98e-02
PI 3K CASCADE FGFR3	12	5.03e-02	1.13e-01	0.5110	-5.13e-02	0.483000	-0.087900	0.128000	-0.023400	7.58e-01	3.76e-03	5.98e-01	4.41e-01	8.88e-01
SCAVENGING BY CLASS A RECEPTORS	13	5.16e-02	1.15e-01	0.5100	1.35e-01	0.286000	-0.268000	-0.289000	0.064900	3.99e-01	7.39e-02	9.45e-02	7.11e-02	6.86e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	7.34e-04	3.90e-03	0.5090	-4.08e-01	-0.142000	0.179000	0.200000	-0.029600	8.39e-05	1.72e-01	8.49e-02	5.46e-02	7.76e-01
ABC TRANSPORTER DISORDERS	68	6.09e-06	5.98e-05	0.5090	2.72e-01	0.284000	-0.294000	0.047800	-0.125000	1.07e-04	5.04e-05	2.73e-05	4.95e-01	7.47e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	12	2.14e-01	3.20e-01	0.5090	2.43e-01	0.349000	-0.123000	0.094200	-0.232000	1.44e-01	3.62e-02	4.62e-01	5.72e-01	1.65e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	1.40e-01	2.37e-01	0.5080	-1.43e-01	0.416000	-0.157000	0.178000	-0.090900	4.10e-01	1.68e-02	3.66e-01	3.08e-01	6.02e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	148	9.13e-15	3.53e-13	0.5080	2.88e-01	0.266000	-0.261000	-0.099900	-0.160000	1.44e-09	2.33e-08	4.17e-08	3.61e-02	7.63e-04
BETA CATENIN PHOSPHORYLATION CASCADE	16	2.82e-02	7.06e-02	0.5080	-2.59e-01	0.324000	-0.066900	0.255000	-0.129000	7.26e-02	2.50e-02	6.43e-01	7.78e-02	3.72e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	1.48e-01	2.46e-01	0.5080	-4.46e-01	-0.050600	0.121000	0.147000	0.142000	1.46e-02	7.82e-01	5.08e-01	4.22e-01	4.37e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	2.16e-01	3.22e-01	0.5070	-3.08e-01	-0.286000	0.135000	0.140000	0.206000	9.14e-02	1.17e-01	4.59e-01	4.44e-01	2.59e-01
DSCAM INTERACTIONS	10	3.05e-01	4.14e-01	0.5060	-4.22e-01	-0.213000	0.177000	-0.034300	0.003310	2.08e-02	2.43e-01	3.31e-01	8.51e-01	9.86e-01
PHASE II CONJUGATION OF COMPOUNDS	60	4.15e-05	3.27e-04	0.5030	2.58e-01	0.314000	-0.194000	0.109000	-0.197000	5.51e-04	2.65e-05	9.23e-03	1.44e-01	8.47e-03
COHESIN LOADING ONTO CHROMATIN	10	3.78e-01	4.78e-01	0.5020	4.61e-02	0.209000	-0.156000	0.350000	-0.244000	8.01e-01	2.52e-01	3.93e-01	5.53e-02	1.81e-01
TRP CHANNELS	18	1.14e-01	2.06e-01	0.5010	-1.43e-01	-0.382000	0.261000	0.002490	0.127000	2.93e-01	4.97e-03	5.51e-02	9.85e-01	3.51e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	49	4.33e-05	3.37e-04	0.4980	3.66e-02	-0.178000	0.218000	-0.355000	0.204000	6.57e-01	3.14e-02	8.32e-03	1.74e-05	1.34e-02
IRON UPTAKE AND TRANSPORT	52	7.90e-04	4.07e-03	0.4980	1.03e-01	0.342000	-0.259000	0.137000	-0.185000	1.97e-01	1.97e-05	1.26e-03	8.74e-02	2.09e-02
SYNTHESIS OF PE	12	1.49e-01	2.47e-01	0.4980	1.59e-01	-0.154000	0.293000	0.292000	0.167000	3.40e-01	3.56e-01	7.88e-02	8.01e-02	3.17e-01
SPHINGOLIPID METABOLISM	79	1.36e-08	2.22e-07	0.4980	1.65e-01	0.263000	-0.036500	0.362000	-0.139000	1.14e-02	5.44e-05	5.75e-01	2.77e-08	3.33e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	1.10e-06	1.26e-05	0.4970	2.07e-01	0.328000	-0.254000	-0.006100	-0.180000	1.21e-03	2.84e-07	7.08e-05	9.24e-01	4.88e-03
INTERLEUKIN 6 FAMILY SIGNALING	18	2.28e-02	6.04e-02	0.4970	3.20e-01	-0.017100	0.308000	0.152000	0.164000	1.87e-02	9.00e-01	2.39e-02	2.66e-01	2.29e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	15	8.82e-02	1.70e-01	0.4960	3.51e-01	0.170000	0.078800	0.262000	0.136000	1.85e-02	2.55e-01	5.97e-01	7.87e-02	3.63e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	10	1.81e-01	2.84e-01	0.4950	-2.83e-01	-0.191000	0.126000	-0.287000	-0.174000	1.21e-01	2.95e-01	4.90e-01	1.17e-01	3.40e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	17	4.97e-02	1.12e-01	0.4950	1.97e-01	0.173000	-0.027100	0.383000	-0.171000	1.60e-01	2.18e-01	8.47e-01	6.31e-03	2.21e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	3.56e-04	2.01e-03	0.4940	1.01e-01	0.307000	-0.034000	0.358000	-0.101000	2.64e-01	6.82e-04	7.06e-01	7.18e-05	2.66e-01
NEPHRIN FAMILY INTERACTIONS	22	1.97e-02	5.43e-02	0.4930	-7.15e-03	0.032500	0.313000	0.265000	0.272000	9.54e-01	7.92e-01	1.11e-02	3.15e-02	2.71e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	1.57e-02	4.51e-02	0.4930	3.73e-01	-0.115000	0.271000	0.034700	0.124000	6.10e-03	3.98e-01	4.62e-02	7.99e-01	3.61e-01
NUCLEOBASE BIOSYNTHESIS	15	7.12e-02	1.45e-01	0.4930	-1.46e-01	0.304000	-0.050700	0.352000	-0.049700	3.28e-01	4.13e-02	7.34e-01	1.83e-02	7.39e-01
NUCLEAR IMPORT OF REV PROTEIN	32	7.37e-04	3.90e-03	0.4920	-3.74e-01	-0.096900	0.190000	0.238000	-0.028900	2.55e-04	3.43e-01	6.34e-02	1.98e-02	7.77e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	2.01e-05	1.76e-04	0.4920	3.18e-01	0.254000	-0.242000	-0.026700	-0.132000	1.49e-05	5.52e-04	9.96e-04	7.16e-01	7.27e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	1.86e-01	2.88e-01	0.4920	-3.47e-02	0.351000	-0.071300	0.298000	-0.153000	8.29e-01	2.86e-02	6.56e-01	6.27e-02	3.38e-01
GAP JUNCTION DEGRADATION	11	2.75e-01	3.84e-01	0.4900	1.23e-01	0.384000	-0.204000	0.189000	0.020400	4.79e-01	2.74e-02	2.41e-01	2.78e-01	9.07e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	3.13e-03	1.27e-02	0.4900	3.63e-02	-0.144000	0.245000	-0.059600	0.393000	6.99e-01	1.24e-01	8.95e-03	5.25e-01	2.75e-05
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	1.33e-01	2.29e-01	0.4900	2.67e-01	0.090300	0.074800	0.177000	0.352000	1.09e-01	5.88e-01	6.54e-01	2.90e-01	3.46e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	1.13e-01	2.04e-01	0.4900	-4.53e-01	-0.072700	0.004280	0.070500	0.157000	1.32e-02	6.91e-01	9.81e-01	6.99e-01	3.89e-01
PROLONGED ERK ACTIVATION EVENTS	13	1.60e-01	2.60e-01	0.4890	-1.85e-01	0.178000	-0.038400	0.344000	-0.231000	2.48e-01	2.68e-01	8.11e-01	3.16e-02	1.49e-01
CLEC7A DECTIN 1 SIGNALING	94	1.01e-07	1.32e-06	0.4890	2.33e-01	0.285000	-0.230000	-0.002350	-0.225000	9.78e-05	1.77e-06	1.16e-04	9.69e-01	1.66e-04
TRANSLESION SYNTHESIS BY POLK	17	1.44e-01	2.41e-01	0.4890	2.85e-02	0.150000	-0.377000	-0.151000	-0.224000	8.39e-01	2.86e-01	7.06e-03	2.80e-01	1.09e-01
FATTY ACID METABOLISM	144	3.49e-12	1.16e-10	0.4890	2.61e-01	0.308000	-0.184000	0.171000	-0.116000	6.92e-08	1.94e-10	1.45e-04	4.04e-04	1.63e-02
FRS MEDIATED FGFR2 SIGNALING	17	8.27e-02	1.62e-01	0.4880	6.81e-02	0.346000	-0.193000	-0.079600	-0.266000	6.27e-01	1.36e-02	1.69e-01	5.70e-01	5.72e-02
PRE NOTCH PROCESSING IN GOLGI	17	1.53e-02	4.45e-02	0.4880	1.24e-01	0.175000	0.342000	0.191000	0.197000	3.77e-01	2.13e-01	1.46e-02	1.73e-01	1.59e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	2.56e-01	3.65e-01	0.4870	1.95e-01	0.348000	-0.226000	-0.154000	-0.055400	2.63e-01	4.54e-02	1.94e-01	3.75e-01	7.50e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	3.46e-02	8.37e-02	0.4870	-3.76e-01	0.181000	0.188000	0.105000	-0.130000	3.10e-02	2.99e-01	2.79e-01	5.46e-01	4.56e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	2.61e-01	3.71e-01	0.4870	1.88e-01	0.127000	-0.345000	0.107000	-0.234000	2.59e-01	4.46e-01	3.86e-02	5.20e-01	1.60e-01
GP1B IX V ACTIVATION SIGNALLING	10	4.85e-01	5.75e-01	0.4870	-1.32e-01	-0.232000	0.207000	-0.132000	0.325000	4.68e-01	2.04e-01	2.58e-01	4.69e-01	7.56e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	1.28e-02	3.80e-02	0.4860	-3.71e-01	-0.155000	0.046900	0.069800	0.259000	8.07e-03	2.68e-01	7.38e-01	6.18e-01	6.43e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	1.15e-01	2.06e-01	0.4850	-2.29e-03	0.257000	-0.327000	0.018600	-0.250000	9.85e-01	3.29e-02	6.69e-03	8.77e-01	3.80e-02
BUDDING AND MATURATION OF HIV VIRION	27	6.08e-02	1.29e-01	0.4840	1.15e-01	0.306000	-0.267000	0.173000	-0.159000	3.02e-01	5.93e-03	1.62e-02	1.19e-01	1.52e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	9.85e-02	1.84e-01	0.4830	2.86e-01	0.154000	-0.096400	0.339000	-0.064000	5.52e-02	3.03e-01	5.18e-01	2.31e-02	6.68e-01
IRE1ALPHA ACTIVATES CHAPERONES	49	1.81e-05	1.60e-04	0.4810	1.20e-01	0.105000	0.231000	0.291000	0.260000	1.46e-01	2.05e-01	5.12e-03	4.18e-04	1.64e-03
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	5.63e-03	1.99e-02	0.4800	-1.28e-01	-0.069900	0.159000	0.032900	0.428000	2.86e-01	5.62e-01	1.88e-01	7.85e-01	3.82e-04
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	3.52e-02	8.48e-02	0.4800	9.64e-02	0.393000	-0.146000	0.202000	-0.072000	4.14e-01	8.74e-04	2.16e-01	8.67e-02	5.41e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	11	7.49e-02	1.51e-01	0.4800	-2.15e-01	0.092700	0.093900	0.253000	0.321000	2.17e-01	5.94e-01	5.90e-01	1.46e-01	6.53e-02
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	2.36e-02	6.19e-02	0.4800	2.58e-01	0.344000	-0.202000	-0.059900	0.027000	3.20e-02	4.27e-03	9.38e-02	6.19e-01	8.22e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.85e-03	1.48e-02	0.4800	-2.62e-01	-0.021500	0.130000	0.374000	-0.061600	2.08e-02	8.49e-01	2.50e-01	9.51e-04	5.87e-01
FORMATION OF APOPTOSOME	10	5.08e-01	5.95e-01	0.4790	2.29e-01	0.217000	-0.233000	0.155000	-0.228000	2.09e-01	2.36e-01	2.02e-01	3.97e-01	2.13e-01
DNA REPLICATION	121	3.54e-09	7.08e-08	0.4790	1.64e-01	0.192000	-0.302000	0.037600	-0.270000	1.80e-03	2.62e-04	9.77e-09	4.75e-01	2.98e-07
REPRESSION OF WNT TARGET GENES	14	2.36e-02	6.19e-02	0.4790	1.52e-01	0.155000	0.302000	-0.147000	0.263000	3.23e-01	3.16e-01	5.03e-02	3.41e-01	8.85e-02
SULFUR AMINO ACID METABOLISM	22	5.70e-02	1.23e-01	0.4790	2.65e-01	0.288000	-0.109000	0.177000	-0.181000	3.15e-02	1.92e-02	3.76e-01	1.52e-01	1.42e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	10	1.32e-01	2.29e-01	0.4780	-1.33e-01	0.154000	-0.075400	-0.191000	-0.381000	4.67e-01	4.00e-01	6.80e-01	2.96e-01	3.68e-02
FERTILIZATION	12	1.94e-01	2.96e-01	0.4780	-1.47e-01	-0.158000	-0.065700	-0.421000	0.017900	3.79e-01	3.42e-01	6.94e-01	1.15e-02	9.15e-01
VOLTAGE GATED POTASSIUM CHANNELS	38	1.35e-03	6.41e-03	0.4770	-3.46e-01	-0.159000	0.263000	0.016100	0.114000	2.24e-04	9.09e-02	4.99e-03	8.63e-01	2.23e-01
PKMTS METHYLATE HISTONE LYSINES	47	1.37e-03	6.47e-03	0.4760	-3.87e-02	-0.321000	0.280000	-0.164000	0.132000	6.46e-01	1.41e-04	9.10e-04	5.22e-02	1.17e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	1.54e-01	2.54e-01	0.4760	2.50e-01	-0.015900	0.243000	-0.079800	0.314000	9.31e-02	9.15e-01	1.03e-01	5.93e-01	3.54e-02
RRNA PROCESSING IN THE MITOCHONDRION	10	3.71e-01	4.75e-01	0.4760	-6.03e-02	0.044900	-0.344000	0.080800	-0.310000	7.41e-01	8.06e-01	5.99e-02	6.58e-01	8.95e-02
DCC MEDIATED ATTRACTIVE SIGNALING	14	4.88e-02	1.10e-01	0.4760	-2.62e-01	0.110000	0.198000	0.226000	0.234000	8.91e-02	4.75e-01	1.99e-01	1.44e-01	1.29e-01
BIOTIN TRANSPORT AND METABOLISM	11	2.48e-01	3.58e-01	0.4740	1.18e-01	0.101000	0.184000	0.270000	0.305000	4.97e-01	5.60e-01	2.90e-01	1.20e-01	7.96e-02
C TYPE LECTIN RECEPTORS CLRS	110	4.07e-08	6.05e-07	0.4740	2.09e-01	0.292000	-0.231000	0.017500	-0.205000	1.55e-04	1.29e-07	2.95e-05	7.51e-01	2.01e-04
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	2.17e-02	5.81e-02	0.4730	2.41e-01	0.299000	-0.226000	0.006870	0.160000	6.90e-02	2.41e-02	8.85e-02	9.59e-01	2.27e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	7.90e-02	1.57e-01	0.4730	1.26e-01	0.077800	-0.334000	0.061200	-0.294000	3.41e-01	5.57e-01	1.18e-02	6.44e-01	2.64e-02
LDL CLEARANCE	16	8.92e-02	1.72e-01	0.4720	-3.62e-02	0.311000	-0.120000	0.332000	0.008380	8.02e-01	3.13e-02	4.05e-01	2.17e-02	9.54e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	27	3.36e-03	1.34e-02	0.4720	2.36e-01	0.333000	-0.122000	0.094300	0.180000	3.39e-02	2.78e-03	2.72e-01	3.97e-01	1.06e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	5.53e-02	1.20e-01	0.4710	1.67e-01	0.131000	-0.339000	0.001810	-0.250000	1.56e-01	2.66e-01	4.08e-03	9.88e-01	3.42e-02
INTERLEUKIN 7 SIGNALING	19	6.10e-02	1.29e-01	0.4710	-2.69e-01	-0.163000	0.161000	-0.105000	0.294000	4.23e-02	2.18e-01	2.26e-01	4.27e-01	2.67e-02
CYTOPROTECTION BY HMOX1	118	8.08e-10	1.91e-08	0.4700	2.55e-01	0.234000	-0.240000	-0.093800	-0.186000	1.75e-06	1.12e-05	6.99e-06	7.86e-02	4.97e-04
S PHASE	153	1.22e-10	3.74e-09	0.4700	1.50e-01	0.223000	-0.271000	0.088200	-0.259000	1.42e-03	2.07e-06	7.00e-09	6.01e-02	3.22e-08
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	23	8.77e-02	1.70e-01	0.4680	2.72e-01	0.257000	-0.214000	0.154000	-0.094800	2.39e-02	3.29e-02	7.55e-02	2.00e-01	4.31e-01
PURINE CATABOLISM	16	2.47e-01	3.58e-01	0.4670	2.63e-01	0.250000	-0.277000	0.025600	-0.096600	6.85e-02	8.40e-02	5.52e-02	8.59e-01	5.03e-01
METABOLISM OF COFACTORS	18	1.20e-01	2.13e-01	0.4660	1.28e-01	0.235000	-0.270000	-0.223000	-0.151000	3.49e-01	8.46e-02	4.71e-02	1.02e-01	2.67e-01
TRANSLESION SYNTHESIS BY POLH	19	7.13e-02	1.45e-01	0.4650	-7.97e-03	0.181000	-0.389000	-0.125000	-0.128000	9.52e-01	1.71e-01	3.32e-03	3.46e-01	3.35e-01
AMINE LIGAND BINDING RECEPTORS	27	2.03e-03	8.74e-03	0.4650	-1.41e-01	0.071500	0.333000	0.253000	0.128000	2.04e-01	5.20e-01	2.72e-03	2.31e-02	2.51e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	58	1.59e-04	1.04e-03	0.4630	-2.14e-01	-0.185000	0.301000	-0.111000	0.175000	4.86e-03	1.46e-02	7.18e-05	1.42e-01	2.09e-02
RA BIOSYNTHESIS PATHWAY	10	3.70e-01	4.74e-01	0.4630	3.48e-01	0.142000	-0.169000	0.120000	-0.173000	5.70e-02	4.37e-01	3.54e-01	5.11e-01	3.43e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	59	9.79e-08	1.29e-06	0.4620	-3.89e-02	-0.251000	0.343000	-0.177000	-0.013000	6.05e-01	8.45e-04	5.34e-06	1.84e-02	8.63e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	1.53e-06	1.69e-05	0.4620	2.16e-01	0.180000	-0.287000	-0.120000	-0.195000	6.28e-04	4.47e-03	5.47e-06	5.81e-02	2.07e-03
PYROPTOSIS	20	1.59e-01	2.60e-01	0.4620	8.15e-02	0.275000	-0.303000	-0.094200	-0.174000	5.28e-01	3.34e-02	1.88e-02	4.66e-01	1.79e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	1.93e-01	2.96e-01	0.4610	-3.67e-02	0.362000	-0.283000	0.022200	0.007920	8.33e-01	3.76e-02	1.05e-01	8.99e-01	9.64e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	1.24e-01	2.18e-01	0.4610	-2.91e-01	-0.021400	0.320000	0.136000	0.082000	6.93e-02	8.94e-01	4.58e-02	3.96e-01	6.09e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	25	2.62e-02	6.72e-02	0.4600	1.24e-02	0.267000	-0.091400	0.362000	-0.032600	9.15e-01	2.11e-02	4.29e-01	1.73e-03	7.78e-01
HYALURONAN UPTAKE AND DEGRADATION	11	3.11e-01	4.17e-01	0.4600	2.07e-01	0.271000	-0.055700	0.280000	0.118000	2.36e-01	1.19e-01	7.49e-01	1.08e-01	4.97e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	1.04e-02	3.23e-02	0.4590	-1.20e-01	-0.148000	-0.045100	0.363000	-0.201000	3.78e-01	2.76e-01	7.40e-01	7.65e-03	1.39e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	4.01e-04	2.23e-03	0.4590	-3.60e-01	-0.119000	0.186000	0.178000	-0.002560	6.51e-05	1.86e-01	3.89e-02	4.87e-02	9.77e-01
PI 3K CASCADE FGFR2	15	1.42e-01	2.40e-01	0.4580	-6.76e-02	0.319000	-0.159000	-0.029000	-0.278000	6.50e-01	3.23e-02	2.87e-01	8.46e-01	6.26e-02
CARNITINE METABOLISM	14	8.29e-02	1.62e-01	0.4580	5.37e-02	0.099200	0.231000	0.377000	-0.037000	7.28e-01	5.21e-01	1.35e-01	1.45e-02	8.11e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	2.82e-04	1.64e-03	0.4570	2.87e-01	0.105000	0.054600	0.090800	0.323000	1.92e-03	2.59e-01	5.56e-01	3.27e-01	4.81e-04
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	7.84e-04	4.07e-03	0.4570	-3.60e-01	-0.125000	0.118000	0.221000	-0.026700	1.51e-04	1.87e-01	2.14e-01	2.03e-02	7.79e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	3.37e-01	4.41e-01	0.4560	1.56e-01	0.349000	-0.057800	0.222000	-0.091200	3.50e-01	3.61e-02	7.29e-01	1.82e-01	5.84e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	6.72e-02	1.39e-01	0.4550	3.90e-01	-0.014400	0.205000	0.073200	0.087600	8.91e-03	9.23e-01	1.70e-01	6.23e-01	5.57e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	2.04e-03	8.74e-03	0.4550	-3.78e-01	-0.078100	0.143000	0.193000	-0.018200	1.72e-04	4.37e-01	1.55e-01	5.56e-02	8.57e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	9.37e-02	1.78e-01	0.4550	-5.86e-03	0.253000	0.209000	0.183000	0.256000	9.72e-01	1.29e-01	2.11e-01	2.73e-01	1.25e-01
SIGNALING BY THE B CELL RECEPTOR BCR	103	1.50e-06	1.68e-05	0.4540	1.71e-01	0.297000	-0.240000	0.040300	-0.170000	2.70e-03	1.91e-07	2.54e-05	4.80e-01	2.92e-03
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	12	2.68e-01	3.78e-01	0.4530	1.94e-01	0.270000	-0.233000	-0.201000	-0.015800	2.46e-01	1.05e-01	1.63e-01	2.28e-01	9.25e-01
CYTOSOLIC TRNA AMINOACYLATION	24	9.15e-02	1.76e-01	0.4530	-1.33e-01	0.202000	-0.216000	0.195000	-0.249000	2.61e-01	8.63e-02	6.68e-02	9.83e-02	3.50e-02
DERMATAN SULFATE BIOSYNTHESIS	11	2.69e-01	3.79e-01	0.4520	2.04e-01	0.268000	0.034000	0.216000	0.209000	2.42e-01	1.24e-01	8.45e-01	2.15e-01	2.30e-01
CELLULAR HEXOSE TRANSPORT	11	4.29e-01	5.24e-01	0.4520	2.88e-02	-0.117000	0.310000	0.220000	0.214000	8.69e-01	5.02e-01	7.53e-02	2.06e-01	2.20e-01
ARACHIDONIC ACID METABOLISM	38	3.03e-03	1.24e-02	0.4520	3.33e-01	0.266000	-0.136000	-0.051300	-0.039000	3.82e-04	4.52e-03	1.46e-01	5.84e-01	6.77e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS	17	1.35e-01	2.32e-01	0.4520	8.88e-02	0.081600	-0.229000	-0.248000	-0.275000	5.26e-01	5.60e-01	1.02e-01	7.63e-02	4.99e-02
REGULATION OF BACH1 ACTIVITY	11	5.40e-01	6.22e-01	0.4510	-8.29e-02	0.198000	-0.297000	0.112000	-0.238000	6.34e-01	2.56e-01	8.80e-02	5.19e-01	1.71e-01
RHOV GTPASE CYCLE	32	1.54e-03	6.99e-03	0.4510	-1.30e-01	-0.129000	0.150000	0.326000	0.203000	2.02e-01	2.07e-01	1.42e-01	1.44e-03	4.67e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	2.84e-01	3.94e-01	0.4510	4.98e-02	-0.090000	0.250000	0.071400	0.354000	7.39e-01	5.46e-01	9.44e-02	6.32e-01	1.76e-02
KILLING MECHANISMS	10	5.03e-01	5.91e-01	0.4490	2.66e-02	-0.330000	0.190000	-0.214000	0.102000	8.84e-01	7.05e-02	2.99e-01	2.42e-01	5.77e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	1.78e-01	2.81e-01	0.4490	-1.77e-01	0.083700	0.136000	0.379000	0.018400	2.69e-01	6.01e-01	3.94e-01	1.79e-02	9.08e-01
KERATAN SULFATE DEGRADATION	11	3.47e-01	4.51e-01	0.4490	3.91e-01	0.172000	-0.103000	0.041000	0.082400	2.49e-02	3.22e-01	5.56e-01	8.14e-01	6.36e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	25	1.78e-02	4.99e-02	0.4480	8.57e-02	0.167000	-0.171000	-0.199000	-0.311000	4.58e-01	1.49e-01	1.38e-01	8.45e-02	7.16e-03
RHOB GTPASE CYCLE	67	8.04e-06	7.46e-05	0.4480	-8.91e-02	-0.041700	0.286000	0.237000	0.231000	2.08e-01	5.55e-01	5.33e-05	8.03e-04	1.09e-03
BIOLOGICAL OXIDATIONS	120	4.76e-09	8.76e-08	0.4480	2.77e-01	0.293000	-0.139000	0.101000	-0.092400	1.69e-07	3.00e-08	8.52e-03	5.53e-02	8.08e-02
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	1.75e-03	7.77e-03	0.4440	-3.68e-01	-0.042200	0.121000	0.208000	-0.047300	2.04e-04	6.71e-01	2.21e-01	3.58e-02	6.34e-01
TRIGLYCERIDE METABOLISM	22	1.15e-01	2.06e-01	0.4440	9.48e-02	0.350000	-0.207000	0.140000	-0.062500	4.42e-01	4.52e-03	9.35e-02	2.57e-01	6.12e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	4.70e-02	1.08e-01	0.4430	-1.65e-01	-0.118000	0.350000	0.172000	0.059200	1.92e-01	3.49e-01	5.55e-03	1.73e-01	6.39e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	1.34e-01	2.30e-01	0.4430	-2.85e-01	-0.185000	0.255000	0.091600	0.085800	2.73e-02	1.52e-01	4.85e-02	4.78e-01	5.07e-01
PEROXISOMAL PROTEIN IMPORT	57	2.51e-04	1.51e-03	0.4430	2.67e-01	0.218000	-0.121000	0.218000	-0.124000	5.00e-04	4.42e-03	1.13e-01	4.49e-03	1.07e-01
TNFR2 NON CANONICAL NF KB PATHWAY	78	4.66e-05	3.58e-04	0.4420	2.50e-01	0.254000	-0.232000	0.027100	-0.119000	1.37e-04	1.04e-04	4.06e-04	6.80e-01	7.04e-02
TCR SIGNALING	99	2.51e-06	2.60e-05	0.4420	2.13e-01	0.254000	-0.216000	0.020100	-0.196000	2.48e-04	1.28e-05	2.08e-04	7.30e-01	7.71e-04
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	1.67e-03	7.50e-03	0.4420	-3.51e-01	-0.054000	0.114000	0.231000	-0.054600	3.31e-04	5.81e-01	2.42e-01	1.83e-02	5.76e-01
RHOBTB2 GTPASE CYCLE	23	1.96e-01	2.98e-01	0.4420	1.07e-01	0.295000	-0.244000	0.120000	-0.150000	3.76e-01	1.44e-02	4.26e-02	3.18e-01	2.13e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	48	6.44e-03	2.20e-02	0.4410	-8.58e-02	-0.211000	0.325000	-0.038400	0.189000	3.04e-01	1.16e-02	9.85e-05	6.46e-01	2.39e-02
EPHRIN SIGNALING	19	1.22e-02	3.65e-02	0.4410	-1.27e-01	0.220000	0.033300	0.275000	0.229000	3.37e-01	9.62e-02	8.02e-01	3.79e-02	8.35e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	28	5.85e-02	1.26e-01	0.4410	1.70e-01	0.133000	-0.276000	-0.022600	-0.266000	1.19e-01	2.24e-01	1.15e-02	8.36e-01	1.47e-02
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	1.79e-01	2.82e-01	0.4410	-3.11e-01	-0.252000	0.147000	0.078900	0.077400	2.65e-02	7.16e-02	2.95e-01	5.73e-01	5.80e-01
RET SIGNALING	36	2.09e-04	1.30e-03	0.4400	-2.96e-01	0.032400	0.252000	0.038900	0.198000	2.10e-03	7.37e-01	8.81e-03	6.86e-01	3.98e-02
PROCESSING OF INTRONLESS PRE MRNAS	19	7.05e-02	1.45e-01	0.4390	-3.14e-01	-0.129000	-0.041400	-0.032700	-0.274000	1.78e-02	3.31e-01	7.55e-01	8.05e-01	3.88e-02
CHAPERONE MEDIATED AUTOPHAGY	19	9.20e-02	1.76e-01	0.4380	5.48e-02	0.264000	-0.341000	-0.032600	-0.040700	6.79e-01	4.63e-02	1.01e-02	8.05e-01	7.59e-01
DAG AND IP3 SIGNALING	40	8.14e-04	4.18e-03	0.4370	-2.40e-01	-0.015500	0.214000	0.250000	0.156000	8.51e-03	8.65e-01	1.94e-02	6.21e-03	8.69e-02
RAB GERANYLGERANYLATION	57	1.99e-03	8.62e-03	0.4370	-8.47e-02	0.217000	-0.233000	0.136000	-0.252000	2.69e-01	4.61e-03	2.32e-03	7.67e-02	1.01e-03
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	3.62e-01	4.66e-01	0.4360	3.13e-01	0.044700	0.111000	0.123000	0.250000	7.19e-02	7.97e-01	5.23e-01	4.80e-01	1.51e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	31	6.16e-03	2.12e-02	0.4360	2.86e-01	0.092800	0.073000	0.020800	0.307000	5.93e-03	3.72e-01	4.82e-01	8.41e-01	3.14e-03
PHASE 4 RESTING MEMBRANE POTENTIAL	14	9.23e-02	1.76e-01	0.4350	-4.24e-01	0.017000	0.060100	-0.076800	0.000271	6.06e-03	9.12e-01	6.97e-01	6.19e-01	9.99e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	42	4.70e-04	2.57e-03	0.4350	3.56e-01	0.087200	-0.058200	-0.185000	0.132000	6.66e-05	3.28e-01	5.14e-01	3.86e-02	1.38e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	1.56e-01	2.56e-01	0.4340	1.36e-01	0.299000	-0.170000	0.218000	-0.063300	2.69e-01	1.51e-02	1.69e-01	7.64e-02	6.07e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	3.82e-01	4.82e-01	0.4330	1.18e-01	0.034600	0.184000	0.165000	0.333000	5.00e-01	8.42e-01	2.90e-01	3.42e-01	5.58e-02
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	2.63e-01	3.72e-01	0.4330	1.53e-01	0.000307	0.175000	0.004100	0.365000	3.22e-01	9.98e-01	2.56e-01	9.79e-01	1.82e-02
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	1.83e-01	2.85e-01	0.4320	1.23e-01	0.130000	-0.320000	-0.032600	-0.227000	3.31e-01	3.04e-01	1.13e-02	7.96e-01	7.14e-02
GLUCONEOGENESIS	27	1.71e-02	4.84e-02	0.4320	-1.86e-02	0.379000	-0.099300	0.130000	-0.125000	8.67e-01	6.44e-04	3.72e-01	2.43e-01	2.61e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	5.18e-02	1.15e-01	0.4310	-2.82e-01	-0.121000	0.184000	0.233000	0.062000	1.90e-02	3.17e-01	1.27e-01	5.34e-02	6.07e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	2.72e-01	3.82e-01	0.4310	1.46e-02	0.214000	0.180000	0.325000	-0.039700	9.36e-01	2.40e-01	3.26e-01	7.49e-02	8.28e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	2.28e-02	6.04e-02	0.4310	2.52e-01	0.011300	0.173000	0.118000	0.279000	1.87e-02	9.16e-01	1.06e-01	2.70e-01	9.39e-03
INTERLEUKIN 15 SIGNALING	12	1.99e-01	3.03e-01	0.4310	-2.92e-01	-0.025200	0.179000	-0.073800	0.249000	8.02e-02	8.80e-01	2.82e-01	6.58e-01	1.35e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	6.63e-03	2.24e-02	0.4310	-2.91e-01	0.030600	-0.001940	0.224000	-0.222000	4.99e-03	7.68e-01	9.85e-01	3.07e-02	3.24e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	12	1.10e-01	2.01e-01	0.4300	2.88e-01	0.007680	0.269000	0.173000	-0.000820	8.40e-02	9.63e-01	1.07e-01	3.00e-01	9.96e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	2.31e-01	3.40e-01	0.4290	4.22e-02	0.235000	-0.300000	-0.088500	-0.170000	7.44e-01	6.92e-02	2.01e-02	4.93e-01	1.87e-01
ACTIVATION OF RAC1	13	1.66e-01	2.67e-01	0.4280	-2.00e-01	0.178000	-0.243000	0.223000	-0.053600	2.11e-01	2.66e-01	1.30e-01	1.64e-01	7.38e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	6.11e-03	2.11e-02	0.4280	-3.24e-01	-0.117000	0.168000	0.189000	0.000305	1.07e-03	2.36e-01	8.96e-02	5.60e-02	9.98e-01
PHOSPHORYLATION OF THE APC C	17	1.67e-01	2.68e-01	0.4280	9.54e-02	0.033700	-0.325000	-0.010800	-0.258000	4.96e-01	8.10e-01	2.02e-02	9.38e-01	6.55e-02
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	28	1.37e-01	2.35e-01	0.4260	6.39e-02	0.236000	-0.290000	-0.016800	-0.194000	5.59e-01	3.09e-02	7.85e-03	8.78e-01	7.60e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	2.93e-01	4.03e-01	0.4250	-3.93e-02	-0.156000	0.237000	0.265000	0.169000	7.99e-01	3.11e-01	1.25e-01	8.61e-02	2.74e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	20	1.47e-01	2.45e-01	0.4250	1.10e-01	0.316000	-0.255000	-0.037700	-0.048700	3.94e-01	1.45e-02	4.87e-02	7.70e-01	7.06e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	2.35e-01	3.45e-01	0.4240	-9.44e-03	-0.122000	0.342000	0.185000	0.117000	9.50e-01	4.14e-01	2.19e-02	2.15e-01	4.34e-01
ELASTIC FIBRE FORMATION	35	3.39e-03	1.35e-02	0.4240	2.18e-01	0.112000	0.129000	0.014100	0.320000	2.56e-02	2.51e-01	1.85e-01	8.85e-01	1.05e-03
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	2.50e-02	6.48e-02	0.4230	2.15e-01	0.312000	0.101000	0.122000	-0.102000	1.14e-01	2.18e-02	4.60e-01	3.72e-01	4.56e-01
RHOU GTPASE CYCLE	33	5.60e-03	1.99e-02	0.4230	-1.43e-01	-0.033300	0.169000	0.296000	0.202000	1.56e-01	7.40e-01	9.27e-02	3.22e-03	4.52e-02
ROS AND RNS PRODUCTION IN PHAGOCYTES	28	7.63e-02	1.53e-01	0.4220	1.21e-01	0.306000	-0.251000	-0.008470	-0.079100	2.67e-01	5.07e-03	2.14e-02	9.38e-01	4.69e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	2.08e-01	3.13e-01	0.4220	-9.59e-02	0.326000	-0.233000	0.086200	0.011700	5.65e-01	5.03e-02	1.62e-01	6.05e-01	9.44e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	1.93e-01	2.95e-01	0.4220	-2.32e-01	0.152000	-0.275000	0.076600	-0.138000	1.19e-01	3.07e-01	6.51e-02	6.08e-01	3.56e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	140	6.36e-08	8.89e-07	0.4210	1.61e-01	0.203000	-0.229000	0.093000	-0.223000	1.05e-03	3.48e-05	2.90e-06	5.78e-02	5.59e-06
MAPK6 MAPK4 SIGNALING	83	2.48e-05	2.12e-04	0.4210	2.37e-01	0.231000	-0.197000	-0.053100	-0.162000	1.93e-04	2.76e-04	1.95e-03	4.03e-01	1.06e-02
RESOLUTION OF D LOOP STRUCTURES	30	1.20e-02	3.61e-02	0.4210	-3.08e-01	-0.187000	0.045800	-0.081000	-0.196000	3.49e-03	7.67e-02	6.64e-01	4.43e-01	6.32e-02
CA DEPENDENT EVENTS	36	1.95e-03	8.53e-03	0.4200	-2.15e-01	0.054200	0.160000	0.304000	0.099600	2.59e-02	5.73e-01	9.77e-02	1.63e-03	3.01e-01
RETROGRADE NEUROTROPHIN SIGNALLING	13	2.49e-01	3.58e-01	0.4200	-1.42e-01	0.039600	0.092600	0.381000	-0.031400	3.77e-01	8.05e-01	5.63e-01	1.74e-02	8.45e-01
INOSITOL PHOSPHATE METABOLISM	46	2.51e-04	1.51e-03	0.4200	-1.18e-01	0.057800	0.267000	0.261000	0.140000	1.67e-01	4.98e-01	1.77e-03	2.21e-03	1.00e-01
ANTIMICROBIAL PEPTIDES	13	4.01e-01	4.98e-01	0.4190	2.93e-01	0.270000	-0.111000	0.012100	-0.067600	6.71e-02	9.23e-02	4.89e-01	9.40e-01	6.73e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	3.40e-04	1.94e-03	0.4190	-3.75e-01	-0.039300	0.114000	0.137000	-0.039300	1.32e-05	6.49e-01	1.86e-01	1.13e-01	6.48e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	21	1.23e-01	2.17e-01	0.4190	5.93e-02	0.334000	-0.107000	0.219000	-0.023500	6.38e-01	7.97e-03	3.95e-01	8.21e-02	8.52e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	17	7.22e-02	1.47e-01	0.4190	6.25e-02	0.396000	-0.112000	0.024300	0.035300	6.56e-01	4.68e-03	4.22e-01	8.62e-01	8.01e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	2.61e-01	3.71e-01	0.4190	7.39e-02	-0.299000	0.199000	-0.196000	-0.047800	6.71e-01	8.60e-02	2.53e-01	2.61e-01	7.84e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	13	1.83e-01	2.85e-01	0.4180	-3.36e-01	-0.201000	0.010200	0.013400	0.145000	3.57e-02	2.09e-01	9.49e-01	9.33e-01	3.65e-01
METALLOPROTEASE DUBS	24	1.40e-01	2.37e-01	0.4180	1.65e-02	0.219000	-0.191000	-0.015500	-0.300000	8.88e-01	6.32e-02	1.06e-01	8.96e-01	1.11e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	4.10e-02	9.62e-02	0.4180	5.88e-02	0.246000	0.006870	0.331000	0.027000	6.04e-01	3.02e-02	9.52e-01	3.46e-03	8.12e-01
RAF ACTIVATION	34	1.05e-02	3.26e-02	0.4170	-7.03e-02	0.273000	-0.036600	0.274000	-0.136000	4.78e-01	5.82e-03	7.12e-01	5.77e-03	1.71e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	18	3.45e-03	1.37e-02	0.4160	-2.36e-01	0.207000	-0.110000	0.086600	0.236000	8.36e-02	1.29e-01	4.20e-01	5.25e-01	8.33e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	1.73e-01	2.74e-01	0.4160	-1.62e-01	-0.164000	0.080400	-0.331000	-0.059700	2.61e-01	2.57e-01	5.78e-01	2.18e-02	6.79e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	92	4.36e-05	3.37e-04	0.4150	1.98e-01	0.263000	-0.222000	0.068100	-0.101000	1.06e-03	1.33e-05	2.28e-04	2.59e-01	9.51e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS	11	5.34e-02	1.18e-01	0.4150	-1.46e-01	0.121000	-0.297000	-0.135000	0.173000	4.03e-01	4.87e-01	8.80e-02	4.38e-01	3.20e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	6.03e-03	2.10e-02	0.4140	6.18e-03	0.321000	-0.030600	0.225000	-0.131000	9.49e-01	8.65e-04	7.51e-01	1.96e-02	1.74e-01
OLFACTORY SIGNALING PATHWAY	21	2.06e-02	5.58e-02	0.4140	9.94e-03	0.078400	-0.277000	-0.291000	0.063300	9.37e-01	5.34e-01	2.82e-02	2.09e-02	6.16e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	1.70e-02	4.82e-02	0.4140	-2.37e-01	0.174000	0.112000	0.172000	0.208000	7.43e-02	1.90e-01	3.99e-01	1.95e-01	1.17e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	5.37e-02	1.18e-01	0.4140	7.25e-03	-0.079600	-0.170000	-0.355000	-0.098600	9.52e-01	5.09e-01	1.59e-01	3.18e-03	4.13e-01
G2 M CHECKPOINTS	130	3.15e-07	3.89e-06	0.4140	1.06e-01	0.156000	-0.276000	-0.040100	-0.240000	3.75e-02	2.12e-03	5.71e-08	4.31e-01	2.28e-06
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	4.08e-02	9.62e-02	0.4130	3.78e-02	-0.065400	0.359000	0.083500	0.170000	7.39e-01	5.64e-01	1.51e-03	4.61e-01	1.33e-01
RHO GTPASES ACTIVATE KTN1	11	6.76e-01	7.31e-01	0.4130	1.61e-01	0.269000	-0.187000	0.139000	-0.135000	3.54e-01	1.23e-01	2.83e-01	4.24e-01	4.38e-01
NETRIN 1 SIGNALING	48	1.53e-03	6.99e-03	0.4130	-2.60e-01	-0.102000	0.213000	0.150000	0.155000	1.80e-03	2.19e-01	1.06e-02	7.32e-02	6.27e-02
RHO GTPASES ACTIVATE CIT	18	1.23e-01	2.17e-01	0.4120	2.99e-01	0.216000	-0.075400	-0.149000	0.076800	2.82e-02	1.13e-01	5.80e-01	2.75e-01	5.73e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	9.52e-02	1.80e-01	0.4120	1.21e-01	0.020500	-0.270000	0.116000	-0.261000	3.62e-01	8.77e-01	4.15e-02	3.83e-01	4.88e-02
SIGNALING BY FGFR4 IN DISEASE	10	3.70e-01	4.74e-01	0.4120	-4.49e-02	0.308000	-0.254000	-0.087900	-0.023000	8.06e-01	9.22e-02	1.64e-01	6.30e-01	9.00e-01
LONG TERM POTENTIATION	23	7.90e-02	1.57e-01	0.4110	-2.07e-01	-0.147000	0.299000	0.118000	0.038100	8.64e-02	2.22e-01	1.30e-02	3.26e-01	7.52e-01
DNA METHYLATION	19	6.66e-02	1.39e-01	0.4110	2.07e-01	-0.006150	-0.016500	-0.355000	-0.012200	1.18e-01	9.63e-01	9.01e-01	7.45e-03	9.26e-01
G PROTEIN MEDIATED EVENTS	52	5.02e-05	3.80e-04	0.4110	-1.73e-01	0.085100	0.140000	0.301000	0.147000	3.11e-02	2.88e-01	8.02e-02	1.73e-04	6.77e-02
CHONDROITIN SULFATE BIOSYNTHESIS	18	1.69e-01	2.69e-01	0.4090	2.44e-01	0.065600	0.149000	0.212000	0.192000	7.36e-02	6.30e-01	2.73e-01	1.20e-01	1.58e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	19	3.84e-02	9.14e-02	0.4080	5.63e-02	0.396000	-0.061500	0.035400	0.040700	6.71e-01	2.83e-03	6.43e-01	7.89e-01	7.59e-01
INSULIN PROCESSING	24	6.64e-03	2.24e-02	0.4080	-1.50e-01	0.087200	-0.156000	0.333000	0.035900	2.05e-01	4.60e-01	1.86e-01	4.78e-03	7.61e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	18	2.31e-01	3.40e-01	0.4070	-3.89e-02	0.223000	-0.159000	0.287000	-0.085500	7.75e-01	1.02e-01	2.44e-01	3.50e-02	5.30e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	1.47e-01	2.45e-01	0.4070	1.97e-01	0.241000	-0.219000	-0.107000	-0.096800	9.41e-02	4.06e-02	6.38e-02	3.65e-01	4.12e-01
ERYTHROPOIETIN ACTIVATES RAS	13	3.05e-01	4.14e-01	0.4070	1.40e-01	0.355000	-0.045200	0.131000	0.026000	3.84e-01	2.67e-02	7.78e-01	4.12e-01	8.71e-01
INTERLEUKIN 1 SIGNALING	95	2.40e-05	2.08e-04	0.4070	2.20e-01	0.258000	-0.165000	0.047800	-0.144000	2.08e-04	1.41e-05	5.40e-03	4.21e-01	1.56e-02
PHASE I FUNCTIONALIZATION OF COMPOUNDS	57	7.73e-04	4.06e-03	0.4060	2.90e-01	0.251000	-0.083500	0.097900	0.031400	1.54e-04	1.03e-03	2.76e-01	2.01e-01	6.82e-01
INTERLEUKIN 20 FAMILY SIGNALING	12	4.51e-01	5.43e-01	0.4060	1.42e-01	-0.023500	0.296000	0.051700	0.231000	3.96e-01	8.88e-01	7.54e-02	7.56e-01	1.65e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	36	2.86e-02	7.11e-02	0.4060	1.77e-01	0.117000	-0.266000	-0.141000	-0.170000	6.57e-02	2.24e-01	5.77e-03	1.43e-01	7.77e-02
APOPTOTIC FACTOR MEDIATED RESPONSE	18	3.24e-01	4.28e-01	0.4060	2.17e-01	0.153000	-0.237000	-0.043700	-0.189000	1.10e-01	2.60e-01	8.20e-02	7.48e-01	1.65e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	3.99e-01	4.97e-01	0.4050	-3.81e-02	0.301000	-0.225000	-0.019800	-0.146000	8.05e-01	5.10e-02	1.46e-01	8.98e-01	3.44e-01
INTEGRIN SIGNALING	24	1.68e-02	4.79e-02	0.4050	3.43e-02	0.174000	0.256000	0.168000	0.198000	7.71e-01	1.40e-01	3.02e-02	1.54e-01	9.34e-02
PLATELET ADHESION TO EXPOSED COLLAGEN	11	3.13e-01	4.19e-01	0.4050	6.81e-02	0.275000	-0.260000	-0.114000	0.052400	6.96e-01	1.14e-01	1.35e-01	5.13e-01	7.64e-01
SIGNALING BY FGFR2 IN DISEASE	35	2.02e-02	5.49e-02	0.4050	4.84e-02	0.207000	-0.195000	-0.168000	-0.229000	6.20e-01	3.39e-02	4.57e-02	8.61e-02	1.92e-02
RAP1 SIGNALLING	15	2.52e-01	3.61e-01	0.4050	-1.58e-01	0.173000	-0.004740	0.310000	-0.112000	2.89e-01	2.45e-01	9.75e-01	3.77e-02	4.53e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	4.15e-01	5.12e-01	0.4040	2.09e-01	0.097900	-0.147000	-0.294000	-0.043700	2.29e-01	5.74e-01	3.98e-01	9.14e-02	8.02e-01
FC EPSILON RECEPTOR FCERI SIGNALING	123	5.50e-06	5.46e-05	0.4040	1.13e-01	0.266000	-0.208000	0.062400	-0.180000	3.06e-02	3.58e-07	7.13e-05	2.33e-01	5.60e-04
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	4.29e-03	1.61e-02	0.4040	-3.25e-01	-0.054100	0.184000	0.143000	0.003000	6.19e-04	5.69e-01	5.31e-02	1.33e-01	9.75e-01
GLUCAGON TYPE LIGAND RECEPTORS	23	1.00e-01	1.86e-01	0.4030	1.76e-01	0.232000	-0.262000	-0.094300	-0.000593	1.45e-01	5.40e-02	2.95e-02	4.34e-01	9.96e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	2.17e-02	5.81e-02	0.4030	1.77e-01	0.250000	0.074100	0.210000	0.138000	9.90e-02	1.98e-02	4.90e-01	5.05e-02	1.99e-01
ANCHORING FIBRIL FORMATION	13	3.40e-01	4.44e-01	0.4030	-1.39e-01	-0.313000	0.175000	-0.097300	-0.068800	3.87e-01	5.06e-02	2.75e-01	5.44e-01	6.68e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	1.47e-01	2.45e-01	0.4020	-2.30e-01	-0.188000	0.258000	0.084400	0.010100	6.85e-02	1.36e-01	4.08e-02	5.03e-01	9.36e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	21	4.74e-02	1.08e-01	0.4010	6.16e-02	0.253000	0.132000	0.274000	-0.014700	6.25e-01	4.45e-02	2.95e-01	2.95e-02	9.07e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	1.43e-03	6.63e-03	0.4010	-1.36e-01	-0.135000	-0.214000	-0.051700	-0.275000	1.37e-01	1.40e-01	1.90e-02	5.72e-01	2.65e-03
ACYL CHAIN REMODELLING OF PG	10	4.92e-01	5.83e-01	0.4010	1.83e-01	0.121000	-0.033700	0.308000	-0.128000	3.15e-01	5.09e-01	8.53e-01	9.14e-02	4.84e-01
ERKS ARE INACTIVATED	13	2.42e-01	3.53e-01	0.4010	-1.74e-01	0.199000	0.066200	0.268000	-0.120000	2.77e-01	2.14e-01	6.80e-01	9.42e-02	4.55e-01
INFLAMMASOMES	18	3.24e-01	4.28e-01	0.4000	1.53e-01	0.304000	-0.197000	-0.006330	-0.076800	2.62e-01	2.57e-02	1.48e-01	9.63e-01	5.73e-01
PI METABOLISM	79	4.58e-07	5.53e-06	0.4000	-1.87e-01	-0.003580	0.250000	0.247000	0.036400	4.08e-03	9.56e-01	1.19e-04	1.47e-04	5.76e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	7.06e-02	1.45e-01	0.3990	1.07e-01	0.364000	-0.060100	-0.110000	-0.009210	4.59e-01	1.18e-02	6.77e-01	4.48e-01	9.49e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	2.63e-01	3.72e-01	0.3990	-4.24e-02	-0.207000	0.017500	-0.333000	-0.063700	7.76e-01	1.66e-01	9.07e-01	2.57e-02	6.70e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	2.51e-01	3.60e-01	0.3990	-1.82e-02	-0.147000	0.244000	0.228000	0.160000	8.94e-01	2.80e-01	7.31e-02	9.43e-02	2.41e-01
LYSOSOME VESICLE BIOGENESIS	32	1.92e-02	5.31e-02	0.3980	-9.76e-02	0.304000	-0.141000	0.182000	-0.064200	3.40e-01	2.95e-03	1.68e-01	7.52e-02	5.30e-01
RND2 GTPASE CYCLE	38	6.06e-03	2.11e-02	0.3980	-1.49e-01	-0.136000	0.153000	0.188000	0.242000	1.11e-01	1.46e-01	1.02e-01	4.45e-02	9.81e-03
GLUTAMATE AND GLUTAMINE METABOLISM	13	3.32e-01	4.36e-01	0.3980	-9.35e-02	0.240000	0.009980	0.297000	-0.062800	5.59e-01	1.34e-01	9.50e-01	6.41e-02	6.95e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	12	4.36e-01	5.29e-01	0.3980	1.82e-01	-0.039900	0.281000	0.114000	0.178000	2.75e-01	8.11e-01	9.25e-02	4.93e-01	2.84e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	2.17e-01	3.23e-01	0.3980	1.54e-01	0.073400	-0.275000	0.036500	-0.228000	2.46e-01	5.80e-01	3.78e-02	7.83e-01	8.52e-02
SIGNALING BY NOTCH4	83	1.18e-04	8.12e-04	0.3980	2.27e-01	0.247000	-0.194000	-0.029900	-0.084800	3.54e-04	1.01e-04	2.29e-03	6.37e-01	1.82e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	4.27e-01	5.22e-01	0.3960	1.07e-01	0.336000	-0.164000	-0.015100	-0.072200	5.04e-01	3.59e-02	3.07e-01	9.25e-01	6.52e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	4.22e-01	5.19e-01	0.3940	1.56e-01	0.287000	-0.098400	0.196000	0.027400	3.13e-01	6.32e-02	5.24e-01	2.04e-01	8.59e-01
REGULATION OF TNFR1 SIGNALING	34	1.69e-02	4.80e-02	0.3940	2.42e-01	0.062600	0.104000	0.121000	0.259000	1.44e-02	5.28e-01	2.93e-01	2.21e-01	9.05e-03
MATURATION OF NUCLEOPROTEIN	10	5.41e-01	6.23e-01	0.3940	-3.19e-01	-0.134000	-0.063000	-0.097700	-0.148000	8.04e-02	4.65e-01	7.30e-01	5.93e-01	4.18e-01
SEPARATION OF SISTER CHROMATIDS	163	5.12e-08	7.33e-07	0.3940	8.34e-02	0.171000	-0.247000	0.110000	-0.214000	6.67e-02	1.66e-04	5.78e-08	1.55e-02	2.38e-06
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	23	1.01e-01	1.87e-01	0.3940	1.44e-01	0.161000	-0.177000	-0.247000	-0.128000	2.32e-01	1.82e-01	1.42e-01	4.06e-02	2.89e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	1.09e-02	3.34e-02	0.3930	1.60e-01	0.245000	-0.223000	0.009780	0.137000	1.43e-01	2.47e-02	4.12e-02	9.29e-01	2.10e-01
INTRA GOLGI TRAFFIC	43	1.67e-03	7.50e-03	0.3920	-1.07e-01	0.007250	0.199000	0.321000	0.011400	2.25e-01	9.34e-01	2.41e-02	2.76e-04	8.98e-01
METABOLISM OF STEROID HORMONES	19	2.41e-01	3.51e-01	0.3910	2.13e-01	0.081100	-0.251000	-0.077700	-0.177000	1.07e-01	5.41e-01	5.79e-02	5.58e-01	1.81e-01
TRANS GOLGI NETWORK VESICLE BUDDING	69	1.29e-04	8.68e-04	0.3910	-8.92e-02	0.263000	-0.137000	0.223000	-0.083600	2.00e-01	1.62e-04	4.93e-02	1.35e-03	2.30e-01
CD28 CO STIMULATION	29	4.88e-02	1.10e-01	0.3900	2.45e-02	0.130000	-0.056900	0.345000	-0.113000	8.19e-01	2.25e-01	5.96e-01	1.30e-03	2.93e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	54	1.34e-03	6.35e-03	0.3900	-1.19e-01	0.235000	-0.157000	0.222000	-0.095100	1.31e-01	2.88e-03	4.56e-02	4.76e-03	2.27e-01
TIE2 SIGNALING	17	3.47e-01	4.51e-01	0.3900	5.39e-02	0.307000	-0.214000	0.076900	-0.054100	7.01e-01	2.86e-02	1.26e-01	5.83e-01	6.99e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	1.69e-04	1.10e-03	0.3890	-1.66e-01	-0.025800	0.275000	0.218000	0.015100	3.83e-02	7.47e-01	6.19e-04	6.60e-03	8.51e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	5.52e-01	6.28e-01	0.3880	2.08e-01	0.205000	-0.204000	-0.138000	-0.072900	2.13e-01	2.20e-01	2.21e-01	4.09e-01	6.62e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	77	4.71e-05	3.60e-04	0.3880	2.12e-02	-0.015300	0.259000	0.215000	0.192000	7.48e-01	8.16e-01	8.71e-05	1.12e-03	3.65e-03
HOST INTERACTIONS OF HIV FACTORS	123	2.81e-05	2.38e-04	0.3880	7.43e-02	0.234000	-0.217000	0.103000	-0.181000	1.55e-01	7.80e-06	3.34e-05	4.92e-02	5.40e-04
LYSINE CATABOLISM	11	3.87e-01	4.86e-01	0.3880	2.91e-01	0.076500	0.008840	0.232000	-0.074900	9.44e-02	6.61e-01	9.60e-01	1.83e-01	6.67e-01
CDC42 GTPASE CYCLE	152	3.18e-09	6.59e-08	0.3880	-6.41e-02	-0.068200	0.288000	0.121000	0.209000	1.73e-01	1.47e-01	9.05e-10	1.00e-02	8.73e-06
JOSEPHIN DOMAIN DUBS	11	3.85e-01	4.85e-01	0.3880	1.01e-01	0.351000	-0.083100	-0.029100	-0.097100	5.63e-01	4.41e-02	6.33e-01	8.67e-01	5.77e-01
RMTS METHYLATE HISTONE ARGININES	41	3.00e-03	1.23e-02	0.3880	7.66e-02	-0.011400	0.193000	-0.234000	0.228000	3.96e-01	9.00e-01	3.22e-02	9.40e-03	1.17e-02
SIGNALING BY NTRK3 TRKC	17	3.24e-01	4.28e-01	0.3860	-8.90e-02	-0.194000	0.099600	-0.147000	0.268000	5.25e-01	1.66e-01	4.77e-01	2.94e-01	5.54e-02
ACTIVATION OF MATRIX METALLOPROTEINASES	14	2.05e-01	3.09e-01	0.3860	-3.52e-01	0.005920	0.127000	0.032800	-0.088300	2.27e-02	9.69e-01	4.11e-01	8.32e-01	5.67e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	20	7.41e-02	1.50e-01	0.3850	1.07e-01	0.130000	-0.099000	-0.332000	0.018400	4.09e-01	3.13e-01	4.43e-01	1.03e-02	8.87e-01
SHC1 EVENTS IN EGFR SIGNALING	10	5.24e-01	6.11e-01	0.3850	1.09e-01	0.290000	-0.177000	-0.140000	-0.031600	5.50e-01	1.13e-01	3.31e-01	4.44e-01	8.63e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	5.30e-01	6.15e-01	0.3840	-1.76e-01	-0.148000	0.156000	-0.202000	0.171000	2.72e-01	3.55e-01	3.31e-01	2.08e-01	2.85e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	1.04e-01	1.92e-01	0.3840	-8.56e-02	-0.107000	0.226000	0.141000	0.240000	4.17e-01	3.12e-01	3.25e-02	1.80e-01	2.30e-02
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	36	7.73e-04	4.06e-03	0.3840	5.01e-02	0.305000	-0.121000	0.080100	0.175000	6.03e-01	1.55e-03	2.11e-01	4.06e-01	6.92e-02
CD28 DEPENDENT PI3K AKT SIGNALING	19	1.37e-01	2.35e-01	0.3810	-6.02e-02	-0.047000	0.166000	0.334000	-0.008610	6.50e-01	7.23e-01	2.12e-01	1.16e-02	9.48e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	2.60e-04	1.56e-03	0.3810	-1.37e-01	-0.131000	0.268000	0.082700	0.175000	2.89e-02	3.75e-02	2.01e-05	1.88e-01	5.20e-03
PEXOPHAGY	11	3.63e-01	4.66e-01	0.3810	1.28e-01	0.225000	0.108000	0.096600	0.239000	4.62e-01	1.96e-01	5.36e-01	5.79e-01	1.70e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	48	6.30e-05	4.62e-04	0.3800	-1.48e-01	-0.164000	0.228000	-0.177000	-0.111000	7.71e-02	4.94e-02	6.34e-03	3.37e-02	1.82e-01
SIGNALING BY RETINOIC ACID	30	1.06e-01	1.94e-01	0.3790	6.09e-02	0.274000	-0.116000	0.221000	-0.048900	5.64e-01	9.41e-03	2.70e-01	3.62e-02	6.43e-01
PLASMA LIPOPROTEIN ASSEMBLY	11	1.63e-01	2.64e-01	0.3790	8.11e-02	0.161000	-0.149000	0.134000	0.267000	6.41e-01	3.57e-01	3.93e-01	4.42e-01	1.26e-01
O LINKED GLYCOSYLATION OF MUCINS	37	1.00e-02	3.15e-02	0.3790	3.33e-02	0.065800	0.201000	0.303000	0.076900	7.26e-01	4.89e-01	3.43e-02	1.45e-03	4.18e-01
MTORC1 MEDIATED SIGNALLING	24	1.59e-01	2.59e-01	0.3780	8.85e-02	0.148000	-0.251000	0.188000	-0.122000	4.53e-01	2.09e-01	3.33e-02	1.10e-01	3.01e-01
CONDENSATION OF PROPHASE CHROMOSOMES	26	4.34e-02	1.01e-01	0.3780	-4.40e-03	0.097300	-0.146000	-0.323000	-0.087800	9.69e-01	3.91e-01	1.98e-01	4.31e-03	4.38e-01
MISMATCH REPAIR	14	1.33e-01	2.30e-01	0.3780	2.62e-01	-0.008210	-0.162000	0.217000	-0.028600	8.99e-02	9.58e-01	2.94e-01	1.60e-01	8.53e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	2.46e-01	3.56e-01	0.3780	1.93e-01	0.066900	-0.021800	0.296000	-0.115000	1.97e-01	6.54e-01	8.84e-01	4.74e-02	4.42e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	26	3.99e-02	9.46e-02	0.3780	-1.19e-02	0.175000	0.153000	0.258000	0.147000	9.16e-01	1.22e-01	1.78e-01	2.27e-02	1.95e-01
COLLAGEN DEGRADATION	47	3.23e-04	1.86e-03	0.3750	-1.65e-01	-0.168000	0.229000	-0.162000	-0.082500	4.98e-02	4.63e-02	6.69e-03	5.49e-02	3.28e-01
EFFECTS OF PIP2 HYDROLYSIS	27	1.28e-01	2.22e-01	0.3750	-1.88e-01	-0.097600	0.241000	0.147000	0.128000	9.05e-02	3.80e-01	3.04e-02	1.88e-01	2.50e-01
PCP CE PATHWAY	89	1.53e-04	1.01e-03	0.3750	2.54e-01	0.198000	-0.164000	0.002450	-0.101000	3.51e-05	1.22e-03	7.64e-03	9.68e-01	1.01e-01
RNA POLYMERASE III CHAIN ELONGATION	18	2.25e-01	3.33e-01	0.3730	1.86e-02	-0.072500	-0.167000	-0.308000	-0.106000	8.92e-01	5.95e-01	2.20e-01	2.37e-02	4.38e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	9.46e-02	1.79e-01	0.3730	2.46e-01	0.162000	0.201000	-0.106000	-0.023800	1.41e-01	3.33e-01	2.27e-01	5.25e-01	8.87e-01
REGULATION OF IFNG SIGNALING	13	4.33e-01	5.27e-01	0.3710	1.44e-01	0.143000	-0.187000	0.245000	-0.038200	3.67e-01	3.71e-01	2.44e-01	1.26e-01	8.12e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	107	3.25e-05	2.68e-04	0.3710	1.97e-01	0.190000	-0.223000	-0.060900	-0.098900	4.46e-04	6.80e-04	6.95e-05	2.77e-01	7.73e-02
TRAFFICKING OF AMPA RECEPTORS	31	6.28e-02	1.32e-01	0.3710	-2.49e-01	-0.127000	0.146000	0.030300	0.194000	1.66e-02	2.21e-01	1.59e-01	7.70e-01	6.16e-02
SHC MEDIATED CASCADE FGFR1	14	3.52e-01	4.56e-01	0.3710	1.66e-02	0.260000	-0.139000	-0.126000	-0.187000	9.15e-01	9.27e-02	3.69e-01	4.13e-01	2.25e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA	12	4.10e-01	5.07e-01	0.3710	4.76e-02	0.007830	0.084100	0.343000	0.104000	7.75e-01	9.63e-01	6.14e-01	3.97e-02	5.35e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	92	3.14e-05	2.62e-04	0.3710	2.51e-01	0.211000	-0.170000	-0.040600	0.003600	3.29e-05	4.74e-04	4.94e-03	5.01e-01	9.52e-01
GABA RECEPTOR ACTIVATION	52	8.76e-06	8.07e-05	0.3710	-1.02e-01	0.216000	-0.182000	0.190000	0.108000	2.05e-01	7.19e-03	2.36e-02	1.76e-02	1.80e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	9.32e-02	1.77e-01	0.3710	4.42e-02	-0.030800	0.253000	0.052900	0.261000	6.65e-01	7.63e-01	1.33e-02	6.04e-01	1.08e-02
KERATAN SULFATE BIOSYNTHESIS	23	7.79e-02	1.55e-01	0.3710	1.46e-01	0.239000	0.115000	0.172000	0.128000	2.26e-01	4.76e-02	3.40e-01	1.54e-01	2.88e-01
G ALPHA 12 13 SIGNALLING EVENTS	74	2.08e-04	1.30e-03	0.3700	4.57e-02	0.002120	0.261000	0.152000	0.210000	4.97e-01	9.75e-01	1.07e-04	2.35e-02	1.84e-03
NEUREXINS AND NEUROLIGINS	54	7.50e-03	2.49e-02	0.3700	-4.13e-02	-0.073200	0.295000	0.055800	0.199000	6.00e-01	3.53e-01	1.76e-04	4.78e-01	1.15e-02
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	4.29e-01	5.24e-01	0.3700	7.38e-02	0.182000	-0.016000	0.296000	-0.101000	6.21e-01	2.21e-01	9.14e-01	4.72e-02	4.99e-01
NEUTROPHIL DEGRANULATION	376	3.80e-19	2.10e-17	0.3690	1.78e-01	0.256000	-0.166000	0.098500	-0.039700	3.30e-09	1.65e-17	3.86e-08	1.08e-03	1.88e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	3.48e-03	1.37e-02	0.3690	3.00e-02	0.284000	-0.083900	0.051100	0.212000	7.80e-01	8.18e-03	4.34e-01	6.34e-01	4.81e-02
TIGHT JUNCTION INTERACTIONS	16	3.20e-01	4.25e-01	0.3690	-7.44e-02	0.173000	-0.040200	0.179000	-0.259000	6.06e-01	2.30e-01	7.81e-01	2.16e-01	7.33e-02
RHOC GTPASE CYCLE	73	4.24e-04	2.33e-03	0.3680	-8.43e-03	-0.042200	0.212000	0.191000	0.228000	9.01e-01	5.33e-01	1.73e-03	4.71e-03	7.55e-04
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	7.60e-03	2.51e-02	0.3680	6.49e-02	0.153000	-0.058200	0.312000	-0.084300	4.32e-01	6.33e-02	4.81e-01	1.60e-04	3.08e-01
UCH PROTEINASES	88	2.74e-04	1.62e-03	0.3670	2.11e-01	0.182000	-0.199000	-0.077700	-0.108000	6.47e-04	3.18e-03	1.26e-03	2.08e-01	7.93e-02
SUMOYLATION OF DNA METHYLATION PROTEINS	16	2.82e-01	3.93e-01	0.3670	-2.51e-01	-0.095200	0.237000	-0.069000	0.042800	8.23e-02	5.10e-01	1.01e-01	6.33e-01	7.67e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	4.50e-03	1.67e-02	0.3670	1.36e-01	0.072200	0.141000	0.158000	0.258000	1.03e-01	3.87e-01	9.22e-02	5.90e-02	2.02e-03
NUCLEAR ENVELOPE BREAKDOWN	47	4.94e-03	1.81e-02	0.3660	-2.49e-01	-0.068100	0.152000	0.207000	0.034600	3.16e-03	4.20e-01	7.14e-02	1.43e-02	6.81e-01
SARS COV 2 INFECTION	65	1.85e-03	8.15e-03	0.3650	1.00e-01	0.284000	-0.112000	0.173000	-0.011300	1.63e-01	7.48e-05	1.17e-01	1.60e-02	8.75e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	1.55e-01	2.55e-01	0.3650	-6.83e-02	0.105000	-0.149000	0.160000	-0.264000	5.24e-01	3.28e-01	1.66e-01	1.37e-01	1.37e-02
SIGNALING BY FGFR2 IIIA TM	19	3.24e-01	4.28e-01	0.3650	1.43e-01	0.206000	-0.153000	-0.107000	-0.188000	2.82e-01	1.21e-01	2.48e-01	4.21e-01	1.55e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	73	4.10e-04	2.26e-03	0.3650	-1.10e-01	-0.072000	0.285000	0.119000	0.143000	1.03e-01	2.88e-01	2.57e-05	7.93e-02	3.52e-02
NEGATIVE REGULATION OF FGFR4 SIGNALING	21	1.73e-01	2.74e-01	0.3640	-3.77e-02	0.296000	-0.045100	0.193000	-0.066900	7.65e-01	1.89e-02	7.21e-01	1.25e-01	5.95e-01
DEFECTS IN COBALAMIN B12 METABOLISM	12	5.38e-01	6.22e-01	0.3640	1.91e-01	0.123000	-0.080700	0.263000	-0.074800	2.53e-01	4.62e-01	6.28e-01	1.14e-01	6.54e-01
PLASMA LIPOPROTEIN REMODELING	13	1.21e-01	2.14e-01	0.3640	-2.62e-01	0.053500	-0.055500	0.143000	0.193000	1.01e-01	7.38e-01	7.29e-01	3.73e-01	2.28e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	2.98e-01	4.08e-01	0.3640	2.31e-01	0.174000	0.048400	-0.168000	0.135000	1.50e-01	2.77e-01	7.63e-01	2.94e-01	4.01e-01
AQUAPORIN MEDIATED TRANSPORT	39	1.21e-03	5.88e-03	0.3640	-4.15e-04	0.308000	-0.136000	0.075900	0.114000	9.96e-01	8.72e-04	1.43e-01	4.12e-01	2.17e-01
COLLAGEN FORMATION	74	6.73e-06	6.39e-05	0.3630	-4.17e-02	-0.174000	0.290000	-0.127000	0.009990	5.35e-01	9.72e-03	1.67e-05	5.88e-02	8.82e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	23	9.25e-02	1.76e-01	0.3630	-3.41e-02	0.304000	-0.008790	0.188000	-0.053600	7.77e-01	1.16e-02	9.42e-01	1.19e-01	6.56e-01
REGULATED NECROSIS	45	3.21e-02	7.88e-02	0.3620	3.12e-02	0.193000	-0.263000	-0.098800	-0.116000	7.17e-01	2.48e-02	2.26e-03	2.52e-01	1.77e-01
PRC2 METHYLATES HISTONES AND DNA	28	5.59e-02	1.21e-01	0.3620	2.25e-01	0.002870	-0.077800	-0.272000	-0.006540	3.94e-02	9.79e-01	4.76e-01	1.27e-02	9.52e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	14	3.62e-01	4.66e-01	0.3610	1.40e-01	0.293000	0.031300	0.156000	-0.000631	3.66e-01	5.79e-02	8.40e-01	3.11e-01	9.97e-01
RNA POLYMERASE I PROMOTER ESCAPE	46	5.79e-03	2.03e-02	0.3610	2.21e-01	0.069500	-0.140000	-0.186000	-0.148000	9.45e-03	4.15e-01	1.01e-01	2.88e-02	8.19e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	23	2.78e-02	7.00e-02	0.3600	-8.91e-02	0.226000	0.114000	0.159000	0.180000	4.59e-01	6.06e-02	3.46e-01	1.87e-01	1.35e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	5.55e-01	6.29e-01	0.3590	1.39e-01	-0.061900	0.075800	-0.050100	0.313000	4.24e-01	7.22e-01	6.64e-01	7.74e-01	7.27e-02
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	56	1.74e-03	7.77e-03	0.3590	-3.15e-01	-0.082300	0.136000	0.055300	0.037300	4.52e-05	2.87e-01	7.92e-02	4.74e-01	6.30e-01
BILE ACID AND BILE SALT METABOLISM	24	1.20e-01	2.13e-01	0.3590	1.46e-01	0.207000	0.088600	0.238000	0.019400	2.17e-01	7.96e-02	4.52e-01	4.34e-02	8.69e-01
HSF1 ACTIVATION	25	3.24e-01	4.28e-01	0.3590	7.25e-02	0.182000	-0.255000	-0.071900	-0.144000	5.30e-01	1.16e-01	2.76e-02	5.34e-01	2.13e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	2.28e-02	6.04e-02	0.3580	-1.11e-01	-0.051800	0.172000	-0.183000	0.224000	2.43e-01	5.86e-01	7.10e-02	5.45e-02	1.82e-02
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	7.58e-02	1.52e-01	0.3580	-7.17e-02	0.282000	-0.199000	-0.027400	-0.054700	5.27e-01	1.28e-02	7.90e-02	8.09e-01	6.29e-01
MITOTIC METAPHASE AND ANAPHASE	203	4.04e-08	6.05e-07	0.3570	6.71e-02	0.170000	-0.210000	0.128000	-0.184000	9.99e-02	3.16e-05	2.63e-07	1.67e-03	6.36e-06
SARS COV 1 INFECTION	48	4.54e-02	1.05e-01	0.3570	8.85e-02	0.258000	-0.141000	0.163000	-0.080600	2.89e-01	1.96e-03	9.20e-02	5.04e-02	3.34e-01
SIGNALING BY CSF3 G CSF	29	1.67e-01	2.69e-01	0.3570	2.00e-01	0.234000	-0.176000	-0.023400	-0.021100	6.19e-02	2.89e-02	1.00e-01	8.27e-01	8.44e-01
SIGNALING BY BMP	24	3.64e-02	8.72e-02	0.3570	-1.28e-02	0.251000	-0.073200	0.184000	0.158000	9.14e-01	3.34e-02	5.35e-01	1.20e-01	1.80e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	1.62e-01	2.62e-01	0.3550	-6.01e-02	0.078600	0.205000	0.115000	0.247000	6.42e-01	5.43e-01	1.12e-01	3.72e-01	5.58e-02
RHOBTB1 GTPASE CYCLE	23	2.73e-01	3.82e-01	0.3550	9.50e-02	0.116000	-0.208000	0.180000	-0.167000	4.30e-01	3.34e-01	8.42e-02	1.36e-01	1.65e-01
GPVI MEDIATED ACTIVATION CASCADE	31	7.01e-02	1.45e-01	0.3550	9.22e-02	0.292000	-0.021300	0.174000	-0.035900	3.75e-01	4.86e-03	8.38e-01	9.35e-02	7.30e-01
KERATAN SULFATE KERATIN METABOLISM	29	6.47e-02	1.36e-01	0.3550	1.77e-01	0.212000	0.086600	0.164000	0.123000	9.96e-02	4.83e-02	4.19e-01	1.25e-01	2.53e-01
SIGNALING BY HIPPO	20	2.02e-01	3.06e-01	0.3540	-9.67e-02	0.180000	-0.053800	0.284000	0.003730	4.54e-01	1.64e-01	6.77e-01	2.77e-02	9.77e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	22	1.47e-01	2.45e-01	0.3530	3.05e-02	0.296000	-0.113000	-0.059200	-0.141000	8.05e-01	1.63e-02	3.57e-01	6.31e-01	2.51e-01
RND3 GTPASE CYCLE	37	4.46e-02	1.03e-01	0.3530	-5.42e-02	-0.148000	0.152000	0.139000	0.239000	5.68e-01	1.19e-01	1.11e-01	1.42e-01	1.20e-02
SIGNALING BY WNT IN CANCER	30	1.66e-02	4.76e-02	0.3530	-1.02e-01	0.198000	0.139000	0.235000	0.007160	3.34e-01	6.09e-02	1.88e-01	2.57e-02	9.46e-01
FCGR3A MEDIATED IL10 SYNTHESIS	32	6.42e-03	2.20e-02	0.3520	-1.06e-01	0.194000	0.082900	0.178000	0.192000	3.01e-01	5.76e-02	4.17e-01	8.11e-02	6.07e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	2.94e-01	4.05e-01	0.3520	1.60e-01	0.183000	-0.221000	-0.101000	-0.078400	1.75e-01	1.21e-01	6.15e-02	3.90e-01	5.06e-01
ERK MAPK TARGETS	22	8.02e-02	1.59e-01	0.3520	-1.78e-01	0.092400	0.121000	0.220000	-0.145000	1.50e-01	4.53e-01	3.28e-01	7.40e-02	2.39e-01
PEPTIDE HORMONE METABOLISM	57	2.79e-04	1.63e-03	0.3520	4.81e-02	0.167000	-0.268000	0.149000	0.000542	5.31e-01	2.91e-02	4.74e-04	5.21e-02	9.94e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	5.91e-02	1.26e-01	0.3520	1.71e-01	0.237000	-0.052900	0.038900	0.185000	1.31e-01	3.64e-02	6.41e-01	7.32e-01	1.03e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	13	2.16e-01	3.22e-01	0.3520	3.01e-01	0.067100	0.124000	0.075400	-0.089000	6.05e-02	6.75e-01	4.40e-01	6.38e-01	5.78e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	21	4.97e-01	5.86e-01	0.3510	8.53e-02	0.222000	-0.197000	-0.014500	-0.166000	4.99e-01	7.77e-02	1.18e-01	9.09e-01	1.88e-01
HIV TRANSCRIPTION INITIATION	45	2.82e-02	7.06e-02	0.3500	8.35e-02	0.091000	-0.169000	-0.018900	-0.280000	3.33e-01	2.91e-01	4.94e-02	8.27e-01	1.15e-03
ACYL CHAIN REMODELLING OF PE	16	4.27e-01	5.22e-01	0.3490	1.99e-01	0.148000	-0.015500	0.236000	-0.068600	1.69e-01	3.06e-01	9.15e-01	1.02e-01	6.35e-01
N GLYCAN ANTENNAE ELONGATION	15	1.40e-01	2.37e-01	0.3490	3.56e-02	0.216000	0.077200	-0.032000	0.259000	8.12e-01	1.48e-01	6.05e-01	8.30e-01	8.24e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	1.98e-01	3.02e-01	0.3480	-1.29e-01	0.295000	0.106000	0.077800	0.026700	4.60e-01	9.07e-02	5.44e-01	6.55e-01	8.78e-01
FRS MEDIATED FGFR1 SIGNALING	16	3.79e-01	4.79e-01	0.3470	4.02e-02	0.291000	-0.106000	-0.015800	-0.150000	7.81e-01	4.36e-02	4.64e-01	9.13e-01	2.99e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	104	1.32e-05	1.20e-04	0.3460	1.51e-01	0.271000	-0.098000	0.109000	0.044600	7.68e-03	1.79e-06	8.46e-02	5.46e-02	4.32e-01
POLYMERASE SWITCHING	14	6.29e-01	6.95e-01	0.3460	2.32e-01	0.154000	-0.178000	0.065000	-0.077500	1.33e-01	3.19e-01	2.49e-01	6.74e-01	6.16e-01
REDUCTION OF CYTOSOLIC CA LEVELS	11	5.77e-01	6.49e-01	0.3450	-3.38e-01	-0.055800	0.007070	0.013500	-0.044500	5.26e-02	7.49e-01	9.68e-01	9.38e-01	7.98e-01
DISEASES OF CARBOHYDRATE METABOLISM	28	9.32e-02	1.77e-01	0.3450	1.71e-01	0.270000	-0.069500	0.055900	0.095900	1.17e-01	1.36e-02	5.24e-01	6.09e-01	3.80e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	42	1.36e-02	3.99e-02	0.3440	-2.56e-01	-0.017700	0.087400	0.211000	-0.026100	4.13e-03	8.43e-01	3.27e-01	1.80e-02	7.69e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	1.14e-01	2.06e-01	0.3440	-3.68e-02	0.221000	0.129000	0.226000	-0.022500	7.76e-01	8.76e-02	3.20e-01	8.06e-02	8.62e-01
HEDGEHOG ON STATE	82	1.47e-03	6.78e-03	0.3430	2.44e-01	0.189000	-0.115000	0.079200	-0.053300	1.37e-04	3.14e-03	7.11e-02	2.15e-01	4.05e-01
CELL CYCLE CHECKPOINTS	237	7.97e-09	1.43e-07	0.3430	2.67e-02	0.127000	-0.230000	0.041800	-0.214000	4.80e-01	7.48e-04	1.08e-09	2.69e-01	1.51e-08
ECM PROTEOGLYCANS	63	5.62e-03	1.99e-02	0.3430	1.05e-01	-0.079500	0.228000	-0.108000	0.191000	1.51e-01	2.76e-01	1.78e-03	1.38e-01	8.71e-03
SIGNALING BY NOTCH3	48	2.36e-02	6.19e-02	0.3430	-2.93e-02	-0.052700	0.177000	0.051000	0.282000	7.26e-01	5.28e-01	3.39e-02	5.41e-01	7.13e-04
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	6.48e-01	7.07e-01	0.3420	2.38e-01	0.165000	-0.035200	0.172000	-0.047700	1.54e-01	3.22e-01	8.33e-01	3.01e-01	7.75e-01
NUCLEOBASE CATABOLISM	31	1.31e-01	2.26e-01	0.3420	2.62e-01	0.150000	-0.109000	0.118000	0.002530	1.15e-02	1.49e-01	2.96e-01	2.57e-01	9.81e-01
CGMP EFFECTS	15	4.79e-01	5.70e-01	0.3410	-2.21e-01	-0.186000	-0.006510	-0.172000	0.059100	1.39e-01	2.13e-01	9.65e-01	2.48e-01	6.92e-01
INTERLEUKIN 1 FAMILY SIGNALING	119	5.05e-05	3.80e-04	0.3400	1.85e-01	0.235000	-0.107000	0.061400	-0.104000	4.89e-04	9.75e-06	4.44e-02	2.48e-01	4.92e-02
GABA B RECEPTOR ACTIVATION	39	1.79e-03	7.94e-03	0.3400	-2.88e-02	0.215000	-0.065400	0.175000	0.182000	7.55e-01	2.00e-02	4.80e-01	5.82e-02	4.88e-02
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	3.53e-01	4.56e-01	0.3390	-2.03e-03	0.101000	-0.032400	0.148000	0.286000	9.91e-01	5.80e-01	8.59e-01	4.18e-01	1.17e-01
G0 AND EARLY G1	24	7.94e-02	1.57e-01	0.3390	1.30e-01	0.010500	-0.055100	0.244000	-0.187000	2.69e-01	9.29e-01	6.40e-01	3.84e-02	1.13e-01
KINESINS	47	5.11e-02	1.14e-01	0.3390	-5.40e-02	-0.257000	0.168000	0.023900	0.131000	5.22e-01	2.35e-03	4.68e-02	7.77e-01	1.20e-01
MUCOPOLYSACCHARIDOSES	11	5.50e-01	6.26e-01	0.3380	1.01e-01	0.172000	0.116000	0.127000	0.212000	5.64e-01	3.23e-01	5.05e-01	4.65e-01	2.24e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	35	5.21e-02	1.16e-01	0.3380	-7.03e-02	-0.112000	0.257000	0.171000	0.037000	4.72e-01	2.53e-01	8.48e-03	8.09e-02	7.05e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	5.46e-01	6.24e-01	0.3370	5.91e-02	0.190000	0.137000	0.199000	0.126000	7.35e-01	2.75e-01	4.30e-01	2.54e-01	4.69e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	2.72e-01	3.82e-01	0.3370	-1.28e-01	-0.001420	-0.029900	-0.246000	-0.189000	3.74e-01	9.92e-01	8.36e-01	8.84e-02	1.90e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	11	3.77e-01	4.78e-01	0.3370	-1.14e-01	0.175000	0.168000	0.201000	-0.041600	5.14e-01	3.16e-01	3.36e-01	2.49e-01	8.11e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	5.02e-01	5.91e-01	0.3370	5.10e-02	0.251000	0.029500	0.210000	0.052700	7.50e-01	1.18e-01	8.54e-01	1.89e-01	7.42e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	30	5.91e-02	1.26e-01	0.3360	3.76e-02	0.010400	-0.136000	-0.303000	0.039500	7.22e-01	9.21e-01	1.97e-01	4.12e-03	7.08e-01
RHO GTPASES ACTIVATE PKNS	46	1.86e-02	5.19e-02	0.3360	6.83e-02	0.206000	-0.179000	-0.169000	-0.073100	4.23e-01	1.59e-02	3.59e-02	4.74e-02	3.91e-01
HDACS DEACETYLATE HISTONES	44	7.08e-02	1.45e-01	0.3360	-2.72e-02	-0.154000	0.096700	-0.219000	0.176000	7.55e-01	7.65e-02	2.67e-01	1.21e-02	4.31e-02
TRAF6 MEDIATED IRF7 ACTIVATION	15	6.31e-01	6.97e-01	0.3360	4.34e-02	-0.057000	0.245000	0.070200	0.206000	7.71e-01	7.02e-01	1.00e-01	6.38e-01	1.67e-01
SIGNALING BY INSULIN RECEPTOR	60	8.38e-03	2.74e-02	0.3360	-6.56e-02	0.244000	-0.102000	0.114000	-0.159000	3.80e-01	1.08e-03	1.73e-01	1.26e-01	3.28e-02
SYNTHESIS OF PA	29	1.14e-01	2.06e-01	0.3360	7.22e-02	0.105000	0.141000	0.245000	0.129000	5.01e-01	3.30e-01	1.89e-01	2.24e-02	2.31e-01
SIGNALING BY NOTCH2	33	1.93e-01	2.96e-01	0.3350	5.49e-02	-0.068100	0.187000	0.017800	0.264000	5.86e-01	4.99e-01	6.35e-02	8.60e-01	8.75e-03
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	2.85e-02	7.11e-02	0.3350	-2.47e-02	0.277000	-0.171000	-0.074400	-0.001470	8.09e-01	6.68e-03	9.33e-02	4.67e-01	9.89e-01
PARASITE INFECTION	54	2.63e-03	1.11e-02	0.3350	7.60e-03	0.217000	0.068900	0.245000	-0.016700	9.23e-01	5.91e-03	3.82e-01	1.83e-03	8.32e-01
FORMATION OF THE CORNIFIED ENVELOPE	22	1.22e-01	2.15e-01	0.3350	-6.74e-02	-0.034900	0.228000	-0.201000	0.118000	5.84e-01	7.77e-01	6.37e-02	1.03e-01	3.39e-01
KERATINIZATION	22	1.22e-01	2.15e-01	0.3350	-6.74e-02	-0.034900	0.228000	-0.201000	0.118000	5.84e-01	7.77e-01	6.37e-02	1.03e-01	3.39e-01
FCERI MEDIATED MAPK ACTIVATION	28	1.60e-01	2.60e-01	0.3350	-1.42e-01	0.207000	-0.117000	0.159000	-0.101000	1.95e-01	5.75e-02	2.85e-01	1.46e-01	3.57e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	12	6.47e-01	7.07e-01	0.3350	2.19e-01	0.134000	-0.183000	-0.112000	0.003500	1.89e-01	4.21e-01	2.73e-01	5.02e-01	9.83e-01
TNF SIGNALING	43	3.12e-02	7.70e-02	0.3350	1.47e-01	0.071800	0.145000	0.139000	0.212000	9.60e-02	4.16e-01	1.00e-01	1.15e-01	1.61e-02
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	1.03e-02	3.20e-02	0.3340	-1.54e-01	0.070900	-0.006440	0.279000	-0.072100	6.47e-02	3.96e-01	9.38e-01	8.31e-04	3.88e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	3.08e-01	4.15e-01	0.3340	1.91e-01	0.108000	-0.008110	0.249000	0.039100	1.39e-01	4.03e-01	9.50e-01	5.40e-02	7.62e-01
SMOOTH MUSCLE CONTRACTION	33	9.43e-02	1.78e-01	0.3340	8.76e-02	0.206000	-0.205000	-0.135000	-0.032600	3.84e-01	4.08e-02	4.13e-02	1.79e-01	7.46e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	42	5.14e-03	1.85e-02	0.3330	1.72e-01	0.140000	0.044500	-0.176000	0.169000	5.37e-02	1.17e-01	6.18e-01	4.83e-02	5.79e-02
LAGGING STRAND SYNTHESIS	20	5.54e-01	6.29e-01	0.3330	1.45e-01	0.175000	-0.192000	0.106000	-0.105000	2.62e-01	1.76e-01	1.37e-01	4.13e-01	4.15e-01
COSTIMULATION BY THE CD28 FAMILY	47	5.25e-02	1.17e-01	0.3320	-2.15e-05	0.206000	-0.072200	0.227000	-0.104000	1.00e+00	1.44e-02	3.92e-01	7.20e-03	2.16e-01
PECAM1 INTERACTIONS	12	6.03e-01	6.71e-01	0.3310	1.34e-01	0.143000	0.068100	0.193000	0.170000	4.20e-01	3.91e-01	6.83e-01	2.48e-01	3.07e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	23	8.92e-02	1.72e-01	0.3300	1.62e-01	0.158000	-0.128000	-0.072300	0.190000	1.78e-01	1.90e-01	2.87e-01	5.48e-01	1.14e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	3.74e-01	4.78e-01	0.3300	3.35e-02	0.202000	0.128000	0.060200	0.217000	8.41e-01	2.25e-01	4.44e-01	7.18e-01	1.94e-01
G PROTEIN BETA GAMMA SIGNALLING	30	1.68e-01	2.69e-01	0.3290	1.48e-01	0.246000	-0.161000	0.002060	0.018200	1.61e-01	1.99e-02	1.27e-01	9.84e-01	8.63e-01
HYALURONAN METABOLISM	15	4.75e-01	5.66e-01	0.3290	1.51e-01	0.004600	0.088400	0.123000	0.250000	3.11e-01	9.75e-01	5.53e-01	4.09e-01	9.35e-02
PRE NOTCH EXPRESSION AND PROCESSING	62	1.42e-02	4.15e-02	0.3290	-3.13e-02	-0.078900	0.241000	-0.075100	0.193000	6.70e-01	2.83e-01	1.04e-03	3.07e-01	8.52e-03
ACYL CHAIN REMODELLING OF PC	16	3.87e-01	4.86e-01	0.3290	3.05e-01	0.050400	0.014000	0.109000	0.022300	3.48e-02	7.27e-01	9.23e-01	4.49e-01	8.77e-01
OTHER SEMAPHORIN INTERACTIONS	19	5.53e-01	6.28e-01	0.3290	-1.37e-01	-0.130000	0.163000	-0.083200	0.197000	3.03e-01	3.26e-01	2.17e-01	5.30e-01	1.37e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	3.89e-01	4.87e-01	0.3290	-9.33e-02	-0.031700	-0.077100	-0.201000	-0.228000	5.18e-01	8.26e-01	5.93e-01	1.64e-01	1.15e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	6.34e-01	6.99e-01	0.3280	-3.07e-03	0.256000	-0.116000	0.145000	-0.089200	9.84e-01	8.63e-02	4.38e-01	3.31e-01	5.50e-01
REGULATION OF BETA CELL DEVELOPMENT	23	3.16e-01	4.21e-01	0.3280	-1.84e-01	-0.080800	0.224000	-0.017900	0.131000	1.28e-01	5.03e-01	6.36e-02	8.82e-01	2.76e-01
ACTIVATION OF BH3 ONLY PROTEINS	28	8.38e-02	1.64e-01	0.3270	-3.09e-01	-0.015100	-0.081600	0.046200	-0.050200	4.65e-03	8.90e-01	4.55e-01	6.73e-01	6.46e-01
METABOLISM OF PORPHYRINS	19	2.24e-01	3.33e-01	0.3270	2.19e-03	0.221000	0.026200	0.160000	-0.179000	9.87e-01	9.58e-02	8.43e-01	2.27e-01	1.78e-01
G2 M DNA DAMAGE CHECKPOINT	64	9.70e-03	3.07e-02	0.3270	-3.71e-02	0.013000	-0.207000	-0.076700	-0.238000	6.08e-01	8.57e-01	4.23e-03	2.89e-01	9.84e-04
MITOCHONDRIAL TRNA AMINOACYLATION	21	1.82e-01	2.85e-01	0.3270	1.82e-01	-0.049300	0.093600	0.240000	0.069000	1.49e-01	6.96e-01	4.58e-01	5.68e-02	5.84e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE	34	7.10e-02	1.45e-01	0.3270	1.19e-01	0.047300	-0.124000	-0.248000	-0.114000	2.29e-01	6.33e-01	2.11e-01	1.22e-02	2.48e-01
MITOTIC TELOPHASE CYTOKINESIS	13	7.02e-01	7.55e-01	0.3260	-4.10e-02	0.116000	-0.101000	0.208000	-0.194000	7.98e-01	4.68e-01	5.28e-01	1.94e-01	2.25e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	37	8.29e-02	1.62e-01	0.3260	1.99e-01	0.115000	-0.084500	0.200000	-0.077200	3.59e-02	2.27e-01	3.74e-01	3.55e-02	4.16e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	1.29e-01	2.24e-01	0.3260	-4.97e-02	0.142000	-0.197000	0.046100	-0.206000	5.51e-01	8.82e-02	1.84e-02	5.80e-01	1.36e-02
HEME BIOSYNTHESIS	13	3.20e-01	4.25e-01	0.3250	5.58e-02	0.169000	0.114000	0.193000	-0.154000	7.28e-01	2.93e-01	4.75e-01	2.28e-01	3.37e-01
CHROMATIN MODIFYING ENZYMES	216	6.32e-07	7.48e-06	0.3250	-9.54e-02	-0.161000	0.210000	-0.062900	0.149000	1.58e-02	4.65e-05	1.03e-07	1.12e-01	1.63e-04
NEGATIVE REGULATION OF FGFR2 SIGNALING	26	1.84e-01	2.86e-01	0.3250	-4.55e-02	0.230000	-0.058800	0.090100	-0.197000	6.88e-01	4.21e-02	6.04e-01	4.27e-01	8.22e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	3.18e-01	4.23e-01	0.3240	-1.99e-01	-0.125000	0.030100	-0.168000	0.144000	1.23e-01	3.33e-01	8.16e-01	1.93e-01	2.66e-01
RHOH GTPASE CYCLE	37	1.37e-01	2.34e-01	0.3240	2.00e-01	0.193000	-0.159000	0.049200	0.002570	3.52e-02	4.23e-02	9.39e-02	6.05e-01	9.78e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	65	1.75e-02	4.93e-02	0.3240	7.20e-02	0.251000	-0.139000	0.124000	-0.045800	3.15e-01	4.64e-04	5.25e-02	8.44e-02	5.24e-01
NEGATIVE REGULATION OF MET ACTIVITY	20	3.93e-01	4.90e-01	0.3240	4.35e-02	0.192000	-0.002710	0.258000	-0.007950	7.37e-01	1.38e-01	9.83e-01	4.62e-02	9.51e-01
SIGNALING BY FGFR4	31	8.60e-02	1.67e-01	0.3230	1.57e-02	0.296000	-0.064400	0.111000	-0.010300	8.80e-01	4.34e-03	5.35e-01	2.84e-01	9.21e-01
THE PHOTOTRANSDUCTION CASCADE	19	1.59e-01	2.59e-01	0.3230	-1.34e-01	0.082700	-0.178000	-0.216000	0.032100	3.11e-01	5.33e-01	1.79e-01	1.03e-01	8.09e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	5.09e-02	1.14e-01	0.3230	-4.22e-02	-0.069200	0.088400	0.052400	-0.295000	7.44e-01	5.92e-01	4.94e-01	6.85e-01	2.24e-02
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	7.46e-03	2.48e-02	0.3220	1.32e-01	0.176000	0.018600	-0.033200	0.232000	1.43e-01	5.11e-02	8.37e-01	7.13e-01	1.01e-02
MRNA SPLICING MINOR PATHWAY	52	4.87e-02	1.10e-01	0.3220	1.59e-01	0.198000	-0.147000	-0.066400	-0.116000	4.74e-02	1.34e-02	6.72e-02	4.08e-01	1.50e-01
O LINKED GLYCOSYLATION	80	2.92e-03	1.21e-02	0.3220	-9.98e-02	-0.105000	0.247000	0.104000	0.104000	1.23e-01	1.04e-01	1.35e-04	1.07e-01	1.07e-01
PI 3K CASCADE FGFR1	14	4.32e-01	5.26e-01	0.3220	-1.09e-01	0.255000	-0.057200	0.047600	-0.145000	4.80e-01	9.81e-02	7.11e-01	7.58e-01	3.47e-01
SIGNALING BY EGFR IN CANCER	21	1.56e-01	2.56e-01	0.3220	1.88e-02	0.233000	-0.152000	-0.159000	0.023500	8.82e-01	6.47e-02	2.28e-01	2.07e-01	8.52e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	3.05e-01	4.14e-01	0.3220	-3.67e-02	0.192000	-0.084400	0.237000	0.043400	7.82e-01	1.48e-01	5.24e-01	7.32e-02	7.43e-01
REGULATION OF IFNA SIGNALING	12	6.12e-01	6.80e-01	0.3210	6.05e-02	-0.132000	0.091600	0.055800	0.266000	7.17e-01	4.28e-01	5.83e-01	7.38e-01	1.11e-01
G1 S SPECIFIC TRANSCRIPTION	26	4.94e-02	1.11e-01	0.3210	1.73e-01	0.016400	0.024800	0.195000	-0.185000	1.26e-01	8.85e-01	8.27e-01	8.59e-02	1.03e-01
AURKA ACTIVATION BY TPX2	71	1.96e-03	8.53e-03	0.3210	-2.42e-01	-0.168000	0.030400	-0.042000	-0.115000	4.27e-04	1.42e-02	6.58e-01	5.41e-01	9.40e-02
RHOF GTPASE CYCLE	40	2.82e-02	7.06e-02	0.3200	-5.04e-02	0.052100	0.020000	0.309000	0.033400	5.82e-01	5.69e-01	8.27e-01	7.10e-04	7.14e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	1.65e-01	2.67e-01	0.3200	-1.95e-02	0.121000	0.206000	0.136000	0.164000	8.74e-01	3.28e-01	9.50e-02	2.69e-01	1.84e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	46	1.16e-02	3.50e-02	0.3200	1.82e-01	0.055900	-0.069200	-0.234000	-0.080100	3.24e-02	5.12e-01	4.17e-01	6.15e-03	3.47e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	6.00e-01	6.69e-01	0.3190	5.16e-02	0.278000	-0.024300	0.068200	-0.131000	7.67e-01	1.11e-01	8.89e-01	6.95e-01	4.53e-01
PLASMA LIPOPROTEIN CLEARANCE	26	1.86e-01	2.88e-01	0.3180	1.05e-01	0.194000	-0.019000	0.196000	0.118000	3.54e-01	8.72e-02	8.67e-01	8.37e-02	2.96e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	94	2.21e-04	1.35e-03	0.3180	-1.16e-01	-0.057100	0.245000	0.127000	0.091800	5.23e-02	3.39e-01	4.06e-05	3.40e-02	1.24e-01
REGULATION OF KIT SIGNALING	16	3.71e-01	4.75e-01	0.3180	-1.60e-01	-0.068200	0.077500	0.185000	0.175000	2.69e-01	6.37e-01	5.91e-01	1.99e-01	2.26e-01
RHOA GTPASE CYCLE	141	1.13e-06	1.27e-05	0.3180	-3.62e-02	0.012200	0.184000	0.174000	0.188000	4.58e-01	8.03e-01	1.64e-04	3.70e-04	1.21e-04
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	8.51e-02	1.66e-01	0.3170	-1.42e-01	0.114000	0.141000	0.216000	0.030800	1.94e-01	2.95e-01	1.96e-01	4.83e-02	7.78e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	3.83e-02	9.14e-02	0.3170	2.45e-01	-0.045900	-0.084200	-0.107000	-0.141000	1.83e-02	6.58e-01	4.17e-01	3.01e-01	1.75e-01
RESOLUTION OF SISTER CHROMATID COHESION	99	5.79e-04	3.12e-03	0.3170	-8.26e-02	0.103000	-0.130000	0.200000	-0.162000	1.56e-01	7.59e-02	2.53e-02	6.08e-04	5.36e-03
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	21	4.00e-01	4.98e-01	0.3160	-4.58e-02	0.152000	-0.072100	0.107000	-0.241000	7.17e-01	2.27e-01	5.67e-01	3.98e-01	5.62e-02
SIGNALING BY NOTCH1	75	1.15e-02	3.49e-02	0.3160	-1.00e-02	-0.058700	0.209000	0.035000	0.226000	8.81e-01	3.80e-01	1.76e-03	6.00e-01	7.05e-04
SIGNALING BY ERBB2 ECD MUTANTS	16	3.55e-01	4.59e-01	0.3150	3.36e-02	0.230000	-0.153000	-0.147000	0.014900	8.16e-01	1.11e-01	2.89e-01	3.08e-01	9.18e-01
PERK REGULATES GENE EXPRESSION	28	1.73e-01	2.74e-01	0.3150	-2.54e-02	0.202000	-0.101000	-0.043600	-0.214000	8.16e-01	6.41e-02	3.57e-01	6.89e-01	4.99e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	6.04e-02	1.28e-01	0.3150	-5.17e-02	0.090500	-0.067800	0.243000	-0.158000	5.53e-01	2.99e-01	4.37e-01	5.33e-03	7.03e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	86	1.28e-04	8.68e-04	0.3150	1.45e-01	0.177000	-0.037900	0.157000	0.145000	2.04e-02	4.63e-03	5.43e-01	1.22e-02	1.99e-02
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	45	4.80e-02	1.09e-01	0.3140	7.32e-02	-0.058100	0.118000	-0.219000	0.168000	3.96e-01	5.01e-01	1.71e-01	1.11e-02	5.12e-02
DISEASES OF DNA REPAIR	11	4.83e-01	5.74e-01	0.3140	-1.60e-01	-0.157000	-0.014800	0.219000	-0.018400	3.59e-01	3.68e-01	9.32e-01	2.09e-01	9.16e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	2.13e-02	5.72e-02	0.3140	1.18e-01	0.204000	-0.074400	0.086200	0.173000	2.09e-01	2.94e-02	4.28e-01	3.58e-01	6.57e-02
RHOBTB GTPASE CYCLE	35	3.03e-01	4.14e-01	0.3130	1.14e-01	0.176000	-0.183000	0.108000	-0.096100	2.45e-01	7.20e-02	6.15e-02	2.67e-01	3.25e-01
INWARDLY RECTIFYING K CHANNELS	31	4.79e-02	1.09e-01	0.3130	-7.81e-02	0.235000	-0.175000	0.071800	0.031900	4.52e-01	2.35e-02	9.22e-02	4.89e-01	7.58e-01
HIV INFECTION	219	3.94e-06	4.01e-05	0.3130	4.53e-02	0.173000	-0.176000	0.075400	-0.171000	2.49e-01	1.03e-05	7.24e-06	5.49e-02	1.31e-05
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	1.26e-01	2.20e-01	0.3130	8.54e-03	-0.011700	-0.214000	0.004920	-0.228000	9.32e-01	9.07e-01	3.31e-02	9.61e-01	2.35e-02
INTEGRATION OF ENERGY METABOLISM	98	1.09e-05	9.99e-05	0.3130	-1.93e-02	0.106000	0.120000	0.175000	0.204000	7.42e-01	7.09e-02	4.10e-02	2.81e-03	4.88e-04
GAP JUNCTION ASSEMBLY	21	6.58e-01	7.16e-01	0.3130	8.74e-02	0.186000	-0.184000	0.012100	-0.147000	4.88e-01	1.40e-01	1.45e-01	9.24e-01	2.44e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	88	1.21e-04	8.32e-04	0.3130	-1.01e-01	0.152000	0.044200	0.240000	-0.069900	1.00e-01	1.38e-02	4.74e-01	1.01e-04	2.57e-01
SYNTHESIS OF PC	24	3.07e-01	4.15e-01	0.3120	1.75e-01	0.157000	0.042200	0.200000	0.016400	1.39e-01	1.84e-01	7.20e-01	8.94e-02	8.89e-01
PHOSPHOLIPID METABOLISM	183	2.13e-09	4.60e-08	0.3110	-3.66e-02	0.033200	0.188000	0.228000	0.082700	3.94e-01	4.40e-01	1.15e-05	1.12e-07	5.40e-02
PYRIMIDINE CATABOLISM	10	6.07e-01	6.75e-01	0.3100	1.70e-01	-0.047400	-0.105000	-0.099600	-0.211000	3.53e-01	7.95e-01	5.65e-01	5.86e-01	2.49e-01
THE NLRP3 INFLAMMASOME	14	7.71e-01	8.14e-01	0.3100	-6.01e-03	0.205000	-0.178000	-0.020400	-0.149000	9.69e-01	1.84e-01	2.49e-01	8.95e-01	3.34e-01
MITOTIC SPINDLE CHECKPOINT	95	1.30e-03	6.26e-03	0.3100	-6.61e-02	0.090400	-0.173000	0.163000	-0.165000	2.66e-01	1.28e-01	3.60e-03	6.16e-03	5.52e-03
RAC1 GTPASE CYCLE	176	1.23e-08	2.04e-07	0.3100	-4.97e-02	0.017200	0.226000	0.150000	0.141000	2.56e-01	6.94e-01	2.44e-07	6.09e-04	1.30e-03
IRS MEDIATED SIGNALLING	36	4.27e-02	9.98e-02	0.3100	-1.48e-01	0.200000	-0.019400	0.097800	-0.156000	1.25e-01	3.77e-02	8.41e-01	3.10e-01	1.06e-01
LATE ENDOSOMAL MICROAUTOPHAGY	30	2.07e-01	3.12e-01	0.3100	1.22e-01	0.136000	-0.238000	0.062000	-0.048100	2.49e-01	1.98e-01	2.41e-02	5.57e-01	6.48e-01
NEUROTRANSMITTER RELEASE CYCLE	46	2.82e-03	1.18e-02	0.3100	-1.69e-01	0.062200	0.038400	0.170000	0.183000	4.81e-02	4.66e-01	6.52e-01	4.67e-02	3.21e-02
GLYCOSAMINOGLYCAN METABOLISM	112	2.42e-05	2.08e-04	0.3090	1.06e-01	0.108000	0.112000	0.181000	0.166000	5.23e-02	4.89e-02	4.05e-02	9.40e-04	2.48e-03
TRAF6 MEDIATED NF KB ACTIVATION	22	3.05e-01	4.14e-01	0.3090	1.83e-01	0.062700	0.143000	-0.055200	0.185000	1.37e-01	6.11e-01	2.45e-01	6.54e-01	1.34e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	5.17e-01	6.04e-01	0.3080	1.61e-02	0.304000	0.005640	0.016700	-0.037600	9.30e-01	9.57e-02	9.75e-01	9.27e-01	8.37e-01
PURINE SALVAGE	12	8.47e-01	8.76e-01	0.3070	7.24e-02	0.191000	-0.135000	0.161000	-0.094400	6.64e-01	2.53e-01	4.18e-01	3.36e-01	5.71e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	18	4.13e-01	5.11e-01	0.3070	4.58e-02	0.082400	0.009340	0.250000	-0.151000	7.37e-01	5.45e-01	9.45e-01	6.65e-02	2.68e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	5.50e-02	1.20e-01	0.3060	-1.13e-01	0.133000	0.077000	0.158000	0.180000	2.93e-01	2.15e-01	4.73e-01	1.41e-01	9.26e-02
ADHERENS JUNCTIONS INTERACTIONS	29	8.04e-03	2.65e-02	0.3060	-2.27e-01	-0.031600	-0.115000	0.101000	0.135000	3.48e-02	7.69e-01	2.85e-01	3.47e-01	2.10e-01
GAB1 SIGNALOSOME	13	4.15e-01	5.12e-01	0.3060	-1.17e-01	0.114000	0.157000	0.064900	0.194000	4.63e-01	4.75e-01	3.26e-01	6.85e-01	2.25e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	2.83e-02	7.06e-02	0.3060	-2.05e-01	0.175000	-0.030900	0.096700	0.103000	6.06e-02	1.09e-01	7.77e-01	3.76e-01	3.47e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	1.15e-01	2.07e-01	0.3050	-6.75e-04	0.010100	0.278000	0.104000	0.069600	9.95e-01	9.29e-01	1.42e-02	3.57e-01	5.39e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	5.51e-02	1.20e-01	0.3050	-1.28e-01	0.075200	0.142000	0.094400	0.205000	2.09e-01	4.62e-01	1.66e-01	3.56e-01	4.51e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	4.02e-01	4.99e-01	0.3050	5.48e-02	-0.044300	0.221000	0.084000	0.178000	6.29e-01	6.96e-01	5.09e-02	4.59e-01	1.15e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	1.97e-01	3.01e-01	0.3040	-1.36e-01	-0.059600	-0.065600	-0.174000	-0.190000	2.14e-01	5.86e-01	5.48e-01	1.12e-01	8.16e-02
GLUCOSE METABOLISM	80	7.41e-05	5.37e-04	0.3030	-2.34e-01	0.103000	0.072200	0.142000	-0.034300	2.99e-04	1.10e-01	2.64e-01	2.79e-02	5.97e-01
TRNA PROCESSING IN THE NUCLEUS	56	7.04e-03	2.36e-02	0.3030	-1.97e-01	-0.067300	0.051400	0.144000	-0.159000	1.06e-02	3.84e-01	5.06e-01	6.29e-02	4.00e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX	102	6.18e-05	4.57e-04	0.3030	-1.32e-01	-0.148000	0.214000	-0.081900	-0.011700	2.18e-02	9.89e-03	1.91e-04	1.54e-01	8.38e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	1.54e-03	6.99e-03	0.3030	-2.18e-01	-0.160000	0.031900	-0.026400	-0.130000	8.80e-04	1.45e-02	6.27e-01	6.87e-01	4.75e-02
TRANSCRIPTIONAL REGULATION BY MECP2	58	1.23e-01	2.17e-01	0.3020	-8.65e-02	-0.141000	0.176000	-0.047000	0.175000	2.55e-01	6.27e-02	2.04e-02	5.36e-01	2.08e-02
PROGRAMMED CELL DEATH	182	4.11e-05	3.27e-04	0.3020	5.91e-02	0.174000	-0.210000	0.006580	-0.117000	1.70e-01	5.50e-05	1.05e-06	8.79e-01	6.58e-03
RHO GTPASES ACTIVATE ROCKS	19	5.39e-01	6.22e-01	0.3020	1.30e-01	0.166000	-0.155000	-0.137000	-0.064300	3.26e-01	2.11e-01	2.41e-01	3.03e-01	6.28e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	6.47e-01	7.07e-01	0.3020	1.17e-01	0.075700	-0.017000	0.262000	-0.053900	4.65e-01	6.36e-01	9.16e-01	1.02e-01	7.37e-01
MEIOTIC RECOMBINATION	36	1.12e-01	2.04e-01	0.3020	2.16e-02	0.012100	-0.220000	-0.187000	-0.084400	8.23e-01	9.00e-01	2.25e-02	5.21e-02	3.81e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	6.37e-01	7.01e-01	0.3010	2.34e-01	0.126000	0.073800	-0.087900	0.082100	1.79e-01	4.69e-01	6.72e-01	6.14e-01	6.37e-01
PLATELET AGGREGATION PLUG FORMATION	31	4.75e-02	1.08e-01	0.3010	-3.45e-02	0.125000	0.211000	0.099500	0.139000	7.40e-01	2.29e-01	4.22e-02	3.38e-01	1.79e-01
GLYCOLYSIS	66	1.39e-03	6.49e-03	0.3010	-2.72e-01	0.036400	0.067800	0.100000	-0.022100	1.34e-04	6.10e-01	3.41e-01	1.60e-01	7.57e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	1.60e-04	1.04e-03	0.3000	-3.32e-02	0.198000	0.082400	0.207000	-0.000958	6.06e-01	2.07e-03	2.00e-01	1.31e-03	9.88e-01
PLATELET CALCIUM HOMEOSTASIS	25	3.62e-01	4.66e-01	0.2990	-1.71e-01	-0.112000	0.136000	0.154000	0.075100	1.40e-01	3.31e-01	2.39e-01	1.81e-01	5.16e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	2.86e-01	3.96e-01	0.2990	3.63e-02	0.193000	-0.147000	-0.167000	0.041900	7.84e-01	1.46e-01	2.68e-01	2.07e-01	7.52e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	89	8.87e-05	6.31e-04	0.2990	9.73e-02	0.242000	-0.068900	0.066000	0.111000	1.13e-01	7.82e-05	2.62e-01	2.82e-01	7.14e-02
SPRY REGULATION OF FGF SIGNALING	16	5.72e-01	6.44e-01	0.2990	7.88e-03	0.189000	0.017500	0.230000	0.003780	9.57e-01	1.90e-01	9.03e-01	1.11e-01	9.79e-01
PYRIMIDINE SALVAGE	10	4.58e-01	5.50e-01	0.2980	5.38e-02	-0.251000	0.007950	0.102000	0.114000	7.68e-01	1.70e-01	9.65e-01	5.78e-01	5.33e-01
OPIOID SIGNALLING	86	7.98e-05	5.75e-04	0.2970	-6.03e-02	0.195000	-0.011900	0.200000	0.083000	3.34e-01	1.83e-03	8.49e-01	1.37e-03	1.84e-01
SIGNALING BY FGFR3	34	9.55e-02	1.80e-01	0.2970	2.96e-02	0.272000	-0.028100	0.113000	0.000182	7.65e-01	6.13e-03	7.77e-01	2.56e-01	9.99e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	83	6.13e-04	3.28e-03	0.2970	-1.38e-01	-0.051400	0.151000	0.206000	-0.032900	3.02e-02	4.19e-01	1.72e-02	1.18e-03	6.05e-01
APOPTOSIS	160	2.75e-04	1.62e-03	0.2960	8.55e-02	0.170000	-0.200000	-0.001090	-0.107000	6.24e-02	2.16e-04	1.30e-05	9.81e-01	1.98e-02
PROLACTIN RECEPTOR SIGNALING	11	6.37e-01	7.01e-01	0.2960	1.49e-01	0.186000	0.122000	0.113000	0.056500	3.94e-01	2.87e-01	4.82e-01	5.17e-01	7.45e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	105	2.09e-04	1.30e-03	0.2960	8.02e-02	0.060800	0.134000	0.214000	0.116000	1.56e-01	2.82e-01	1.75e-02	1.54e-04	4.05e-02
FGFR2 ALTERNATIVE SPLICING	25	1.50e-01	2.47e-01	0.2950	2.37e-01	-0.066500	-0.083400	-0.114000	-0.080600	4.03e-02	5.65e-01	4.71e-01	3.24e-01	4.86e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	16	6.61e-01	7.17e-01	0.2940	3.71e-02	0.226000	-0.074800	0.168000	-0.012400	7.97e-01	1.17e-01	6.05e-01	2.44e-01	9.31e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	219	1.33e-09	3.09e-08	0.2930	8.46e-02	0.233000	-0.028700	0.145000	0.047300	3.13e-02	3.00e-09	4.64e-01	2.14e-04	2.29e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	34	1.68e-01	2.69e-01	0.2920	-3.24e-02	0.157000	0.022800	0.240000	-0.041300	7.43e-01	1.13e-01	8.18e-01	1.55e-02	6.77e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	26	2.37e-01	3.46e-01	0.2920	1.14e-01	0.187000	0.027800	0.123000	0.147000	3.14e-01	9.94e-02	8.06e-01	2.79e-01	1.95e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	69	1.71e-02	4.84e-02	0.2920	7.87e-03	0.006090	-0.182000	-0.068200	-0.218000	9.10e-01	9.30e-01	9.02e-03	3.27e-01	1.77e-03
SLC TRANSPORTER DISORDERS	67	3.69e-03	1.43e-02	0.2920	-1.54e-01	0.037800	0.079700	0.222000	0.067300	2.94e-02	5.93e-01	2.60e-01	1.70e-03	3.41e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	3.87e-01	4.86e-01	0.2920	-8.00e-02	0.031600	0.074500	0.203000	-0.176000	5.68e-01	8.22e-01	5.95e-01	1.46e-01	2.10e-01
CARDIAC CONDUCTION	102	1.11e-04	7.68e-04	0.2920	-2.25e-01	-0.036000	0.164000	-0.000721	0.079600	8.62e-05	5.30e-01	4.34e-03	9.90e-01	1.65e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	1.91e-01	2.94e-01	0.2920	-1.44e-02	-0.141000	-0.125000	-0.213000	-0.063300	8.95e-01	1.97e-01	2.53e-01	5.11e-02	5.62e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	3.77e-01	4.78e-01	0.2910	-9.19e-03	0.128000	-0.230000	-0.102000	-0.069900	9.37e-01	2.68e-01	4.63e-02	3.76e-01	5.45e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	2.05e-01	3.09e-01	0.2900	-1.29e-01	-0.022700	-0.144000	-0.067500	-0.204000	1.80e-01	8.14e-01	1.34e-01	4.84e-01	3.40e-02
CELLULAR RESPONSES TO EXTERNAL STIMULI	594	4.85e-18	2.25e-16	0.2900	1.52e-01	0.153000	-0.169000	-0.041600	-0.084000	2.88e-10	2.10e-10	2.57e-12	8.50e-02	5.02e-04
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	1.10e-01	2.01e-01	0.2900	1.50e-02	-0.087400	0.173000	0.014200	0.214000	8.42e-01	2.46e-01	2.14e-02	8.51e-01	4.45e-03
DAP12 INTERACTIONS	29	1.42e-01	2.40e-01	0.2890	1.27e-01	0.222000	-0.072700	-0.091200	0.068000	2.36e-01	3.89e-02	4.98e-01	3.95e-01	5.27e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	3.07e-01	4.15e-01	0.2880	-8.10e-02	0.209000	0.132000	0.031700	0.122000	6.13e-01	1.93e-01	4.11e-01	8.43e-01	4.47e-01
RHOG GTPASE CYCLE	73	5.07e-03	1.84e-02	0.2880	2.70e-02	0.147000	0.065000	0.235000	0.027700	6.90e-01	2.97e-02	3.37e-01	5.13e-04	6.82e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	19	6.32e-01	6.97e-01	0.2870	2.04e-02	0.164000	-0.086800	0.212000	-0.048500	8.78e-01	2.16e-01	5.13e-01	1.09e-01	7.14e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	62	1.42e-03	6.61e-03	0.2870	9.13e-02	0.147000	-0.073900	0.132000	0.172000	2.14e-01	4.61e-02	3.14e-01	7.26e-02	1.92e-02
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	1.33e-03	6.35e-03	0.2860	-1.93e-01	-0.161000	0.059000	-0.009630	-0.124000	2.14e-03	1.02e-02	3.48e-01	8.78e-01	4.91e-02
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	31	1.66e-01	2.67e-01	0.2860	1.51e-01	0.044400	0.004110	-0.206000	0.120000	1.46e-01	6.69e-01	9.68e-01	4.74e-02	2.46e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	1.02e-01	1.89e-01	0.2850	1.33e-01	-0.002330	0.067400	0.231000	-0.073800	2.06e-01	9.82e-01	5.23e-01	2.84e-02	4.84e-01
INNATE IMMUNE SYSTEM	759	1.66e-22	1.01e-20	0.2850	1.15e-01	0.215000	-0.114000	0.082400	-0.046400	9.11e-08	1.35e-23	1.09e-07	1.25e-04	3.08e-02
NUCLEAR ENVELOPE NE REASSEMBLY	63	2.08e-02	5.62e-02	0.2850	-6.84e-02	0.076000	-0.020600	0.240000	-0.113000	3.48e-01	2.97e-01	7.77e-01	9.99e-04	1.22e-01
REGULATION OF SIGNALING BY CBL	22	3.78e-01	4.78e-01	0.2840	2.64e-02	0.191000	-0.068100	0.186000	0.067500	8.30e-01	1.22e-01	5.81e-01	1.32e-01	5.84e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	7.75e-01	8.17e-01	0.2840	1.83e-01	0.092200	-0.020000	-0.172000	0.092800	3.16e-01	6.14e-01	9.13e-01	3.45e-01	6.11e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	1.49e-01	2.47e-01	0.2840	2.28e-01	0.161000	0.020200	0.013100	-0.046700	2.79e-02	1.22e-01	8.46e-01	8.99e-01	6.53e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	7.07e-02	1.45e-01	0.2840	-2.01e-01	0.193000	0.000231	-0.039000	0.040200	9.56e-02	1.10e-01	9.98e-01	7.46e-01	7.39e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	3.77e-01	4.78e-01	0.2840	-1.45e-01	0.045600	0.179000	0.119000	0.106000	2.63e-01	7.24e-01	1.66e-01	3.56e-01	4.11e-01
HS GAG DEGRADATION	20	5.99e-01	6.69e-01	0.2830	1.03e-01	-0.092100	0.097100	-0.037500	0.224000	4.26e-01	4.76e-01	4.53e-01	7.72e-01	8.25e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	20	4.99e-01	5.88e-01	0.2830	-1.10e-01	0.137000	-0.033100	0.215000	-0.044200	3.95e-01	2.91e-01	7.98e-01	9.62e-02	7.32e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	137	1.48e-04	9.87e-04	0.2830	2.03e-01	0.150000	-0.123000	-0.025000	0.011100	4.04e-05	2.45e-03	1.28e-02	6.13e-01	8.23e-01
PROTEIN FOLDING	88	2.18e-02	5.81e-02	0.2820	1.66e-01	0.145000	-0.161000	0.021500	-0.069400	7.27e-03	1.85e-02	9.10e-03	7.28e-01	2.61e-01
INTERLEUKIN 10 SIGNALING	17	2.73e-01	3.82e-01	0.2820	6.13e-03	0.169000	-0.128000	-0.134000	0.130000	9.65e-01	2.29e-01	3.62e-01	3.39e-01	3.55e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	5.57e-01	6.30e-01	0.2820	1.56e-01	-0.032700	0.113000	-0.130000	0.156000	2.26e-01	8.00e-01	3.82e-01	3.16e-01	2.27e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	60	3.64e-03	1.42e-02	0.2820	7.26e-02	0.184000	-0.041700	0.108000	0.164000	3.31e-01	1.38e-02	5.77e-01	1.49e-01	2.80e-02
REGULATED PROTEOLYSIS OF P75NTR	12	3.75e-01	4.78e-01	0.2810	7.37e-02	0.198000	0.178000	0.036900	0.038100	6.59e-01	2.35e-01	2.85e-01	8.25e-01	8.19e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	3.96e-01	4.94e-01	0.2810	-9.35e-02	0.066200	0.040900	0.167000	-0.191000	4.80e-01	6.17e-01	7.57e-01	2.08e-01	1.50e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	4.61e-01	5.52e-01	0.2810	1.35e-01	0.031400	0.164000	0.014800	0.181000	2.62e-01	7.95e-01	1.73e-01	9.02e-01	1.34e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	5.73e-01	6.45e-01	0.2810	-2.78e-02	0.167000	-0.165000	-0.056200	-0.141000	8.14e-01	1.57e-01	1.61e-01	6.33e-01	2.32e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	5.58e-01	6.30e-01	0.2810	-2.23e-01	0.054500	0.035100	0.126000	-0.095700	1.22e-01	7.06e-01	8.08e-01	3.84e-01	5.08e-01
G ALPHA Z SIGNALLING EVENTS	43	3.92e-02	9.32e-02	0.2810	6.69e-02	0.178000	-0.075300	0.147000	0.125000	4.48e-01	4.36e-02	3.93e-01	9.65e-02	1.57e-01
NEURONAL SYSTEM	359	6.52e-17	2.91e-15	0.2810	-1.98e-01	-0.010200	0.103000	0.121000	0.119000	1.22e-10	7.42e-01	8.16e-04	8.52e-05	1.20e-04
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	47	9.84e-03	3.10e-02	0.2800	-4.17e-02	0.130000	-0.025200	0.187000	0.155000	6.21e-01	1.23e-01	7.65e-01	2.66e-02	6.58e-02
INTERLEUKIN 17 SIGNALING	66	6.78e-03	2.28e-02	0.2800	-1.65e-01	0.025900	0.090300	0.191000	-0.076200	2.03e-02	7.16e-01	2.05e-01	7.46e-03	2.85e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	57	2.06e-02	5.57e-02	0.2790	-2.23e-01	-0.106000	-0.014000	0.101000	-0.081900	3.63e-03	1.66e-01	8.55e-01	1.87e-01	2.85e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	24	2.37e-01	3.46e-01	0.2790	-3.32e-02	0.255000	-0.108000	-0.016400	-0.006540	7.78e-01	3.07e-02	3.61e-01	8.89e-01	9.56e-01
VIRAL MESSENGER RNA SYNTHESIS	42	1.05e-01	1.94e-01	0.2790	-2.33e-01	-0.076900	0.118000	0.044400	-0.046300	9.12e-03	3.88e-01	1.88e-01	6.19e-01	6.04e-01
DEATH RECEPTOR SIGNALLING	133	1.10e-04	7.66e-04	0.2790	-4.33e-02	-0.022500	0.215000	0.124000	0.118000	3.90e-01	6.55e-01	1.90e-05	1.35e-02	1.90e-02
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	4.97e-01	5.86e-01	0.2790	1.68e-01	0.109000	0.138000	-0.123000	0.058700	3.13e-01	5.15e-01	4.09e-01	4.59e-01	7.25e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	2.56e-01	3.65e-01	0.2790	-9.68e-03	0.157000	-0.115000	0.032300	-0.196000	9.13e-01	7.56e-02	1.91e-01	7.14e-01	2.59e-02
STIMULI SENSING CHANNELS	71	6.57e-02	1.37e-01	0.2780	-7.54e-02	-0.164000	0.196000	0.022900	0.075300	2.73e-01	1.67e-02	4.25e-03	7.39e-01	2.73e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	4.48e-01	5.41e-01	0.2780	-2.32e-01	-0.009590	-0.002130	-0.130000	-0.080900	8.02e-02	9.42e-01	9.87e-01	3.27e-01	5.42e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	75	1.19e-02	3.60e-02	0.2780	-1.46e-01	0.067400	-0.044900	0.177000	-0.134000	2.90e-02	3.13e-01	5.02e-01	8.04e-03	4.44e-02
SIALIC ACID METABOLISM	32	3.29e-01	4.33e-01	0.2780	-1.01e-01	0.136000	-0.058400	0.145000	-0.155000	3.21e-01	1.84e-01	5.68e-01	1.55e-01	1.30e-01
G ALPHA I SIGNALLING EVENTS	179	2.00e-10	5.95e-09	0.2780	-6.58e-02	0.172000	-0.015000	0.168000	0.120000	1.30e-01	7.18e-05	7.30e-01	1.05e-04	5.54e-03
ONCOGENE INDUCED SENESCENCE	32	3.76e-01	4.78e-01	0.2770	1.28e-01	-0.065900	0.142000	0.048800	0.184000	2.09e-01	5.19e-01	1.66e-01	6.33e-01	7.21e-02
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	7.48e-01	7.92e-01	0.2770	4.80e-02	0.193000	-0.143000	-0.050900	-0.121000	7.32e-01	1.69e-01	3.09e-01	7.16e-01	3.87e-01
METABOLISM OF RNA	643	1.02e-18	5.38e-17	0.2770	1.19e-01	0.106000	-0.186000	-0.076900	-0.105000	2.98e-07	5.01e-06	1.27e-15	9.32e-04	6.81e-06
SLC MEDIATED TRANSMEMBRANE TRANSPORT	176	9.75e-07	1.12e-05	0.2770	4.08e-02	0.066100	0.139000	0.168000	0.152000	3.51e-01	1.31e-01	1.53e-03	1.26e-04	4.96e-04
SUMOYLATION OF TRANSCRIPTION FACTORS	16	2.07e-01	3.12e-01	0.2770	-7.27e-03	0.250000	0.022700	-0.103000	-0.052700	9.60e-01	8.29e-02	8.75e-01	4.77e-01	7.15e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	5.03e-01	5.91e-01	0.2770	-1.55e-01	0.137000	-0.079200	0.158000	0.051700	3.17e-01	3.74e-01	6.08e-01	3.06e-01	7.38e-01
ION TRANSPORT BY P TYPE ATPASES	47	2.24e-01	3.33e-01	0.2770	-1.43e-02	-0.073200	0.173000	0.078300	0.186000	8.66e-01	3.85e-01	3.97e-02	3.54e-01	2.71e-02
POTASSIUM CHANNELS	88	3.82e-04	2.13e-03	0.2770	-2.58e-01	-0.011600	0.065000	0.012500	0.074700	2.95e-05	8.50e-01	2.92e-01	8.40e-01	2.26e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	5.32e-02	1.18e-01	0.2760	-8.46e-03	-0.196000	-0.041800	-0.169000	-0.087200	9.24e-01	2.60e-02	6.36e-01	5.56e-02	3.23e-01
NEGATIVE REGULATION OF MAPK PATHWAY	41	1.06e-01	1.94e-01	0.2760	-1.26e-01	0.146000	-0.013600	0.136000	-0.142000	1.61e-01	1.05e-01	8.80e-01	1.31e-01	1.16e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	6.25e-01	6.93e-01	0.2760	-3.12e-02	-0.182000	0.175000	-0.107000	0.011400	8.19e-01	1.81e-01	1.99e-01	4.34e-01	9.33e-01
MET ACTIVATES PTK2 SIGNALING	28	5.90e-01	6.61e-01	0.2760	-3.84e-02	-0.147000	0.201000	0.018200	0.111000	7.25e-01	1.79e-01	6.63e-02	8.68e-01	3.08e-01
TBC RABGAPS	43	4.10e-02	9.62e-02	0.2760	-1.01e-01	0.107000	0.124000	0.196000	-0.023600	2.53e-01	2.23e-01	1.61e-01	2.63e-02	7.89e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	4.52e-03	1.67e-02	0.2750	-2.50e-01	0.029200	0.017100	0.087200	-0.067700	2.26e-04	6.66e-01	8.01e-01	1.98e-01	3.18e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	5.26e-01	6.12e-01	0.2750	8.57e-02	-0.187000	0.089900	-0.143000	-0.068100	5.79e-01	2.25e-01	5.60e-01	3.55e-01	6.59e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	4.64e-01	5.56e-01	0.2740	4.39e-02	0.210000	-0.130000	0.083700	-0.072700	6.63e-01	3.68e-02	1.96e-01	4.06e-01	4.70e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	233	3.46e-12	1.16e-10	0.2730	-1.67e-01	0.038500	0.044900	0.173000	0.117000	1.22e-05	3.12e-01	2.39e-01	5.95e-06	2.16e-03
METABOLISM OF NUCLEOTIDES	91	2.74e-02	6.96e-02	0.2730	1.32e-01	0.141000	-0.120000	0.121000	-0.090200	2.99e-02	1.99e-02	4.75e-02	4.62e-02	1.37e-01
RUNX2 REGULATES BONE DEVELOPMENT	29	3.14e-01	4.20e-01	0.2730	9.44e-02	0.067000	0.138000	0.050900	0.198000	3.79e-01	5.32e-01	1.99e-01	6.35e-01	6.44e-02
DISEASES OF IMMUNE SYSTEM	23	4.18e-01	5.15e-01	0.2730	2.34e-01	0.138000	0.003660	-0.019500	0.003990	5.18e-02	2.52e-01	9.76e-01	8.71e-01	9.74e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	25	3.21e-01	4.26e-01	0.2730	-6.79e-02	0.191000	0.002090	0.138000	-0.119000	5.57e-01	9.85e-02	9.86e-01	2.33e-01	3.01e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	30	3.39e-01	4.43e-01	0.2720	5.88e-02	0.034000	-0.227000	-0.070500	-0.113000	5.77e-01	7.47e-01	3.12e-02	5.04e-01	2.86e-01
CHROMOSOME MAINTENANCE	100	3.63e-03	1.42e-02	0.2710	1.46e-01	0.053000	-0.151000	-0.089100	-0.137000	1.15e-02	3.60e-01	9.06e-03	1.24e-01	1.84e-02
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	2.92e-01	4.02e-01	0.2710	-1.71e-01	0.135000	0.064300	0.136000	-0.056600	1.66e-01	2.72e-01	6.02e-01	2.68e-01	6.46e-01
REGULATION OF INSULIN SECRETION	71	1.20e-03	5.88e-03	0.2710	-9.46e-05	0.090700	0.037100	0.130000	0.217000	9.99e-01	1.87e-01	5.89e-01	5.92e-02	1.60e-03
PREGNENOLONE BIOSYNTHESIS	12	7.04e-01	7.56e-01	0.2710	1.81e-01	0.015400	-0.057600	-0.155000	-0.114000	2.78e-01	9.26e-01	7.30e-01	3.52e-01	4.94e-01
RHOJ GTPASE CYCLE	54	1.98e-02	5.46e-02	0.2710	-9.42e-02	0.111000	-0.011900	0.219000	0.062500	2.32e-01	1.58e-01	8.80e-01	5.37e-03	4.27e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	3.06e-03	1.24e-02	0.2700	-5.42e-02	0.110000	0.033700	0.220000	-0.092700	3.82e-01	7.68e-02	5.87e-01	3.97e-04	1.35e-01
LAMININ INTERACTIONS	27	2.30e-01	3.40e-01	0.2700	-5.27e-02	-0.044900	0.237000	-0.079100	0.076300	6.36e-01	6.86e-01	3.33e-02	4.77e-01	4.93e-01
HEME SIGNALING	44	2.43e-01	3.54e-01	0.2690	-1.54e-01	-0.194000	0.102000	-0.022800	0.013600	7.67e-02	2.61e-02	2.40e-01	7.93e-01	8.76e-01
BASE EXCISION REPAIR AP SITE FORMATION	28	3.07e-01	4.15e-01	0.2690	-1.10e-02	-0.136000	-0.078200	-0.218000	0.007450	9.20e-01	2.14e-01	4.74e-01	4.57e-02	9.46e-01
RHOQ GTPASE CYCLE	57	1.12e-02	3.43e-02	0.2690	-8.69e-02	0.155000	0.083300	0.181000	-0.028400	2.57e-01	4.26e-02	2.77e-01	1.82e-02	7.11e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	76	1.14e-02	3.47e-02	0.2680	1.15e-01	0.188000	-0.127000	0.066400	0.055300	8.36e-02	4.70e-03	5.59e-02	3.17e-01	4.05e-01
NEDDYLATION	212	6.16e-05	4.57e-04	0.2680	7.08e-02	0.151000	-0.105000	0.100000	-0.152000	7.61e-02	1.50e-04	8.34e-03	1.22e-02	1.47e-04
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	1.20e-01	2.13e-01	0.2670	3.71e-02	0.160000	-0.170000	-0.084200	-0.089700	6.22e-01	3.35e-02	2.40e-02	2.63e-01	2.33e-01
SIGNALING BY EGFR	46	5.97e-02	1.27e-01	0.2660	3.17e-02	0.142000	0.096500	0.145000	0.139000	7.10e-01	9.52e-02	2.58e-01	8.92e-02	1.02e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	25	2.38e-01	3.47e-01	0.2660	-1.96e-01	0.098700	0.030200	0.137000	0.054400	8.97e-02	3.93e-01	7.94e-01	2.37e-01	6.38e-01
INSULIN RECEPTOR SIGNALLING CASCADE	41	7.39e-02	1.50e-01	0.2650	-1.30e-01	0.167000	0.011500	0.115000	-0.109000	1.49e-01	6.39e-02	8.99e-01	2.01e-01	2.27e-01
SIGNALING BY FLT3 FUSION PROTEINS	18	2.37e-01	3.46e-01	0.2650	-1.16e-01	-0.089200	-0.086200	-0.087300	0.184000	3.96e-01	5.12e-01	5.27e-01	5.21e-01	1.77e-01
HS GAG BIOSYNTHESIS	29	3.11e-01	4.17e-01	0.2650	7.70e-02	0.129000	0.105000	0.159000	0.106000	4.73e-01	2.29e-01	3.29e-01	1.38e-01	3.25e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	2.65e-01	3.74e-01	0.2640	-7.13e-02	-0.002610	0.036400	0.207000	-0.143000	5.14e-01	9.81e-01	7.39e-01	5.81e-02	1.89e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	21	5.30e-01	6.15e-01	0.2640	4.06e-02	-0.054000	-0.080100	-0.241000	-0.027500	7.47e-01	6.68e-01	5.25e-01	5.63e-02	8.27e-01
EPHB MEDIATED FORWARD SIGNALING	42	2.59e-01	3.69e-01	0.2630	4.23e-02	0.187000	-0.034100	0.165000	-0.064400	6.36e-01	3.63e-02	7.02e-01	6.37e-02	4.71e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	51	1.11e-01	2.02e-01	0.2630	8.29e-02	0.024700	0.111000	0.118000	0.188000	3.06e-01	7.61e-01	1.71e-01	1.45e-01	2.01e-02
MRNA SPLICING	188	6.46e-05	4.71e-04	0.2620	6.24e-02	0.120000	-0.184000	-0.100000	-0.081800	1.41e-01	4.63e-03	1.45e-05	1.78e-02	5.36e-02
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	84	9.32e-03	2.98e-02	0.2620	-2.03e-01	-0.102000	-0.008140	-0.046500	-0.122000	1.32e-03	1.07e-01	8.97e-01	4.62e-01	5.27e-02
ERBB2 ACTIVATES PTK6 SIGNALING	10	8.40e-01	8.71e-01	0.2620	-3.22e-02	-0.089500	0.215000	0.114000	0.019600	8.60e-01	6.24e-01	2.40e-01	5.34e-01	9.14e-01
RND1 GTPASE CYCLE	37	2.30e-01	3.40e-01	0.2620	-1.44e-01	-0.111000	0.094300	0.156000	0.043900	1.29e-01	2.43e-01	3.21e-01	1.00e-01	6.44e-01
SYNDECAN INTERACTIONS	26	2.50e-01	3.60e-01	0.2610	9.15e-02	0.212000	-0.028700	0.002820	0.119000	4.20e-01	6.12e-02	8.00e-01	9.80e-01	2.94e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	3.07e-02	7.58e-02	0.2610	-5.59e-02	-0.077100	-0.118000	-0.084100	-0.195000	4.47e-01	2.94e-01	1.09e-01	2.52e-01	7.79e-03
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	1.23e-02	3.68e-02	0.2610	-1.62e-01	-0.177000	0.075000	-0.065500	-0.025300	6.19e-03	2.69e-03	2.04e-01	2.67e-01	6.69e-01
FOXO MEDIATED TRANSCRIPTION	56	4.07e-02	9.62e-02	0.2610	1.23e-01	0.193000	-0.097500	-0.025900	0.075100	1.11e-01	1.26e-02	2.07e-01	7.37e-01	3.31e-01
INFECTIOUS DISEASE	711	4.57e-18	2.21e-16	0.2610	1.12e-01	0.190000	-0.134000	0.020900	-0.034900	4.01e-07	1.10e-17	1.43e-09	3.46e-01	1.15e-01
HIV ELONGATION ARREST AND RECOVERY	32	1.88e-01	2.91e-01	0.2610	1.30e-02	0.003920	0.013400	-0.258000	0.035500	8.99e-01	9.69e-01	8.96e-01	1.17e-02	7.29e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	64	3.44e-02	8.35e-02	0.2600	1.63e-01	0.044600	-0.096700	-0.147000	-0.090800	2.42e-02	5.37e-01	1.81e-01	4.20e-02	2.09e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	5.86e-01	6.57e-01	0.2590	1.04e-01	0.067000	-0.111000	0.104000	-0.169000	3.90e-01	5.78e-01	3.55e-01	3.87e-01	1.61e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	2.69e-02	6.85e-02	0.2590	3.27e-02	0.005870	-0.085800	-0.212000	-0.116000	6.49e-01	9.35e-01	2.32e-01	3.16e-03	1.05e-01
UNFOLDED PROTEIN RESPONSE UPR	84	3.94e-03	1.51e-02	0.2580	5.16e-02	0.146000	0.093300	0.158000	0.095300	4.14e-01	2.09e-02	1.40e-01	1.22e-02	1.31e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	1.18e-01	2.10e-01	0.2580	5.88e-02	0.119000	0.100000	0.090000	0.175000	5.15e-01	1.89e-01	2.66e-01	3.19e-01	5.22e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	5.42e-01	6.23e-01	0.2570	-3.58e-02	-0.154000	-0.042700	-0.029000	0.196000	8.30e-01	3.55e-01	7.98e-01	8.62e-01	2.40e-01
MTOR SIGNALLING	40	2.48e-01	3.58e-01	0.2570	-3.09e-03	0.071000	-0.057600	0.213000	-0.110000	9.73e-01	4.38e-01	5.29e-01	1.96e-02	2.27e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	6.90e-01	7.44e-01	0.2560	-8.54e-02	-0.072100	0.018300	-0.175000	-0.149000	5.94e-01	6.53e-01	9.09e-01	2.75e-01	3.51e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	117	3.05e-03	1.24e-02	0.2560	-9.14e-02	-0.048300	0.175000	0.127000	0.090800	8.81e-02	3.67e-01	1.08e-03	1.77e-02	9.01e-02
AMYLOID FIBER FORMATION	55	3.25e-02	7.94e-02	0.2560	1.67e-01	0.169000	-0.016100	-0.094400	0.012800	3.21e-02	3.06e-02	8.36e-01	2.26e-01	8.70e-01
CLATHRIN MEDIATED ENDOCYTOSIS	129	2.09e-04	1.30e-03	0.2560	-8.63e-02	0.118000	0.024200	0.207000	-0.027300	9.09e-02	2.12e-02	6.36e-01	4.81e-05	5.93e-01
SIGNALING BY ERYTHROPOIETIN	24	9.68e-02	1.82e-01	0.2560	-5.78e-02	0.190000	0.106000	-0.023200	0.118000	6.24e-01	1.06e-01	3.67e-01	8.44e-01	3.15e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	31	2.61e-01	3.71e-01	0.2560	3.75e-02	0.102000	0.124000	0.195000	0.015000	7.18e-01	3.24e-01	2.34e-01	6.06e-02	8.85e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	11	9.26e-01	9.41e-01	0.2550	3.67e-02	0.197000	-0.104000	0.101000	-0.062900	8.33e-01	2.57e-01	5.51e-01	5.63e-01	7.18e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	2.51e-01	3.60e-01	0.2540	-2.76e-02	-0.044500	0.147000	0.001990	0.200000	7.41e-01	5.94e-01	7.83e-02	9.81e-01	1.64e-02
FCERI MEDIATED CA 2 MOBILIZATION	26	2.12e-01	3.18e-01	0.2540	5.73e-04	0.252000	-0.010800	0.019300	-0.021500	9.96e-01	2.63e-02	9.24e-01	8.65e-01	8.49e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	6.96e-01	7.51e-01	0.2530	-6.78e-02	0.012700	0.241000	0.029700	0.021700	7.10e-01	9.44e-01	1.87e-01	8.71e-01	9.05e-01
RNA POLYMERASE I TRANSCRIPTION	66	2.92e-02	7.25e-02	0.2530	1.99e-01	0.056500	-0.052100	-0.130000	-0.036900	5.09e-03	4.28e-01	4.64e-01	6.71e-02	6.04e-01
SIGNALING BY FGFR1	42	1.84e-01	2.86e-01	0.2530	-4.92e-02	0.216000	-0.080900	0.065000	-0.062500	5.81e-01	1.52e-02	3.64e-01	4.66e-01	4.84e-01
DAP12 SIGNALING	24	3.08e-01	4.15e-01	0.2520	6.97e-02	0.191000	-0.088700	-0.053900	0.106000	5.55e-01	1.05e-01	4.52e-01	6.47e-01	3.71e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	175	2.28e-07	2.88e-06	0.2520	-1.59e-01	0.028100	0.031400	0.170000	0.085600	2.83e-04	5.22e-01	4.74e-01	1.09e-04	5.11e-02
VITAMIN B5 PANTOTHENATE METABOLISM	14	7.12e-01	7.62e-01	0.2520	-5.50e-02	0.123000	0.068000	0.188000	-0.070900	7.22e-01	4.25e-01	6.60e-01	2.23e-01	6.46e-01
BASIGIN INTERACTIONS	22	3.46e-01	4.51e-01	0.2510	-1.15e-01	0.152000	-0.071300	0.137000	0.056400	3.51e-01	2.18e-01	5.62e-01	2.67e-01	6.47e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	61	3.41e-02	8.29e-02	0.2510	1.66e-01	0.029800	-0.014600	-0.185000	0.010900	2.54e-02	6.88e-01	8.44e-01	1.24e-02	8.83e-01
DISEASES OF MITOTIC CELL CYCLE	37	1.14e-01	2.06e-01	0.2510	6.58e-02	-0.062900	-0.147000	0.014600	-0.181000	4.89e-01	5.08e-01	1.23e-01	8.78e-01	5.68e-02
CD209 DC SIGN SIGNALING	18	7.25e-01	7.74e-01	0.2500	2.62e-02	0.206000	-0.078400	0.115000	-0.000491	8.48e-01	1.30e-01	5.65e-01	3.97e-01	9.97e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	7.08e-01	7.59e-01	0.2500	1.98e-01	-0.045000	0.097800	-0.105000	0.022700	2.15e-01	7.79e-01	5.42e-01	5.12e-01	8.88e-01
TP53 REGULATES METABOLIC GENES	84	4.11e-02	9.63e-02	0.2500	3.33e-02	0.143000	-0.124000	-0.084200	-0.137000	5.98e-01	2.40e-02	5.02e-02	1.82e-01	3.06e-02
SIGNALING BY NTRKS	128	3.81e-05	3.11e-04	0.2500	-1.79e-01	0.072300	0.057800	0.141000	0.042400	4.76e-04	1.58e-01	2.59e-01	5.93e-03	4.08e-01
METABOLISM OF CARBOHYDRATES	255	3.62e-09	7.12e-08	0.2490	-2.59e-03	0.159000	0.039500	0.179000	0.056100	9.43e-01	1.21e-05	2.78e-01	9.57e-07	1.24e-01
SIGNALING BY GPCR	437	3.93e-18	1.98e-16	0.2480	-6.79e-02	0.082900	0.089700	0.139000	0.150000	1.53e-02	3.06e-03	1.36e-03	7.09e-07	7.73e-08
AUTOPHAGY	137	5.70e-03	2.01e-02	0.2480	3.83e-02	0.150000	-0.074400	0.165000	-0.068800	4.39e-01	2.47e-03	1.33e-01	8.91e-04	1.65e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	135	4.94e-03	1.81e-02	0.2470	6.07e-02	0.163000	-0.109000	0.135000	-0.029700	2.24e-01	1.11e-03	2.87e-02	6.92e-03	5.51e-01
SIGNALING BY FGFR1 IN DISEASE	32	1.43e-01	2.41e-01	0.2470	-1.55e-01	0.159000	-0.014900	0.100000	0.038400	1.30e-01	1.20e-01	8.84e-01	3.27e-01	7.07e-01
SIGNALING BY NODAL	14	5.44e-01	6.23e-01	0.2470	-6.93e-02	0.137000	0.103000	0.034200	0.159000	6.53e-01	3.74e-01	5.06e-01	8.25e-01	3.02e-01
CA2 PATHWAY	56	2.00e-02	5.46e-02	0.2460	9.42e-02	0.065600	-0.017100	-0.031300	0.215000	2.23e-01	3.96e-01	8.25e-01	6.85e-01	5.36e-03
DNA STRAND ELONGATION	32	6.00e-01	6.69e-01	0.2460	6.93e-02	0.126000	-0.117000	0.139000	-0.084800	4.98e-01	2.19e-01	2.52e-01	1.75e-01	4.07e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	4.51e-01	5.43e-01	0.2460	2.21e-02	0.119000	-0.113000	0.115000	-0.140000	7.97e-01	1.66e-01	1.90e-01	1.83e-01	1.04e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	6.52e-01	7.10e-01	0.2460	-3.65e-02	-0.031200	-0.039000	-0.079600	-0.224000	8.07e-01	8.34e-01	7.94e-01	5.94e-01	1.33e-01
RHO GTPASES ACTIVATE PAKS	21	6.23e-01	6.91e-01	0.2460	1.12e-01	0.151000	-0.141000	-0.062200	0.032000	3.75e-01	2.30e-01	2.62e-01	6.22e-01	8.00e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	2.51e-01	3.60e-01	0.2450	-6.35e-02	0.090900	-0.002410	-0.158000	-0.152000	5.98e-01	4.51e-01	9.84e-01	1.90e-01	2.08e-01
DEADENYLATION OF MRNA	25	3.61e-01	4.65e-01	0.2430	-5.25e-02	-0.010100	-0.082900	0.212000	-0.069000	6.49e-01	9.30e-01	4.73e-01	6.72e-02	5.50e-01
INTEGRIN CELL SURFACE INTERACTIONS	67	4.01e-03	1.53e-02	0.2430	-7.23e-03	-0.036100	0.123000	-0.206000	-0.014600	9.19e-01	6.10e-01	8.17e-02	3.54e-03	8.36e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	1.87e-01	2.89e-01	0.2430	1.80e-01	0.121000	0.098800	-0.036000	0.030100	8.79e-02	2.51e-01	3.49e-01	7.33e-01	7.76e-01
ASSEMBLY OF THE HIV VIRION	16	8.66e-01	8.91e-01	0.2420	1.29e-01	0.101000	-0.163000	0.001520	-0.072900	3.72e-01	4.83e-01	2.59e-01	9.92e-01	6.14e-01
INTERFERON ALPHA BETA SIGNALING	51	8.81e-02	1.70e-01	0.2420	1.56e-01	0.030300	-0.046800	-0.109000	0.139000	5.42e-02	7.08e-01	5.64e-01	1.80e-01	8.54e-02
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	1.81e-01	2.84e-01	0.2420	-5.67e-03	0.103000	-0.074800	0.135000	-0.155000	9.38e-01	1.57e-01	3.05e-01	6.33e-02	3.40e-02
SIGNALING BY VEGF	101	7.86e-04	4.07e-03	0.2420	-7.82e-02	0.155000	0.058800	0.157000	-0.006400	1.75e-01	7.11e-03	3.08e-01	6.36e-03	9.12e-01
G ALPHA Q SIGNALLING EVENTS	142	3.79e-06	3.89e-05	0.2420	2.03e-03	0.128000	-0.001490	0.128000	0.161000	9.67e-01	8.67e-03	9.76e-01	8.78e-03	9.64e-04
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	8.66e-01	8.91e-01	0.2410	1.21e-01	0.081400	-0.090400	0.026800	-0.167000	4.49e-01	6.12e-01	5.73e-01	8.67e-01	2.97e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	2.14e-01	3.20e-01	0.2400	6.96e-02	0.196000	-0.018900	0.111000	0.042300	4.25e-01	2.47e-02	8.28e-01	2.04e-01	6.28e-01
GPCR LIGAND BINDING	224	6.78e-10	1.79e-08	0.2400	1.76e-02	0.140000	-0.012200	0.109000	0.160000	6.51e-01	3.21e-04	7.53e-01	5.08e-03	3.85e-05
MRNA CAPPING	29	3.56e-01	4.59e-01	0.2390	9.05e-02	0.028300	-0.072200	-0.010200	-0.207000	3.99e-01	7.92e-01	5.01e-01	9.24e-01	5.39e-02
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	89	8.82e-03	2.85e-02	0.2390	-8.22e-02	0.162000	-0.023800	0.153000	-0.013200	1.81e-01	8.33e-03	6.98e-01	1.29e-02	8.30e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	2.46e-02	6.39e-02	0.2390	-1.74e-01	0.125000	0.020700	0.065800	-0.080500	2.21e-02	1.01e-01	7.85e-01	3.86e-01	2.89e-01
TELOMERE C STRAND SYNTHESIS INITIATION	13	7.03e-01	7.56e-01	0.2390	3.89e-02	-0.035900	0.027000	0.203000	-0.110000	8.08e-01	8.23e-01	8.66e-01	2.05e-01	4.92e-01
EXTRACELLULAR MATRIX ORGANIZATION	232	6.34e-06	6.07e-05	0.2390	5.30e-02	-0.040600	0.190000	-0.029100	0.125000	1.65e-01	2.88e-01	6.78e-07	4.47e-01	1.04e-03
INTRAFLAGELLAR TRANSPORT	49	8.64e-03	2.81e-02	0.2390	8.83e-02	-0.218000	0.002100	0.038700	0.005680	2.85e-01	8.27e-03	9.80e-01	6.39e-01	9.45e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	6.70e-02	1.39e-01	0.2390	-9.36e-04	0.099100	-0.050300	0.124000	-0.171000	9.89e-01	1.35e-01	4.49e-01	6.28e-02	9.94e-03
VXPX CARGO TARGETING TO CILIUM	19	6.26e-01	6.93e-01	0.2390	-7.19e-02	-0.008710	0.024700	0.226000	0.010100	5.88e-01	9.48e-01	8.52e-01	8.86e-02	9.39e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	33	4.25e-01	5.21e-01	0.2370	9.70e-02	0.125000	-0.147000	0.099200	0.004700	3.35e-01	2.14e-01	1.45e-01	3.24e-01	9.63e-01
RAB REGULATION OF TRAFFICKING	118	7.76e-04	4.06e-03	0.2370	-5.58e-02	0.085800	0.082400	0.192000	-0.043800	2.96e-01	1.08e-01	1.23e-01	3.10e-04	4.12e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	90	1.26e-02	3.74e-02	0.2360	-5.84e-02	0.049800	0.056300	0.211000	-0.047000	3.39e-01	4.15e-01	3.56e-01	5.53e-04	4.42e-01
PEPTIDE LIGAND BINDING RECEPTORS	86	1.50e-04	9.95e-04	0.2360	3.73e-02	0.115000	-0.108000	0.046700	0.165000	5.50e-01	6.50e-02	8.37e-02	4.54e-01	8.33e-03
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	8.35e-01	8.67e-01	0.2360	6.80e-03	0.140000	-0.094000	0.162000	-0.024400	9.62e-01	3.31e-01	5.15e-01	2.61e-01	8.66e-01
VLDLR INTERNALISATION AND DEGRADATION	12	8.56e-01	8.84e-01	0.2350	2.38e-02	0.040500	0.048400	0.224000	-0.026300	8.87e-01	8.08e-01	7.72e-01	1.79e-01	8.75e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	8.18e-01	8.53e-01	0.2350	2.29e-02	0.205000	0.019700	0.088400	-0.066500	8.95e-01	2.38e-01	9.10e-01	6.12e-01	7.03e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	7.96e-01	8.35e-01	0.2350	-1.24e-01	-0.045800	0.145000	0.129000	-0.003920	4.06e-01	7.59e-01	3.32e-01	3.87e-01	9.79e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	1.26e-01	2.20e-01	0.2350	1.40e-02	0.016100	0.044500	0.089000	0.212000	8.74e-01	8.55e-01	6.14e-01	3.13e-01	1.64e-02
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	4.70e-01	5.61e-01	0.2350	6.74e-02	0.061700	-0.023600	-0.215000	0.002200	5.76e-01	6.09e-01	8.44e-01	7.45e-02	9.85e-01
RAC2 GTPASE CYCLE	86	2.72e-02	6.91e-02	0.2340	1.59e-02	0.089100	0.036700	0.212000	0.014700	8.00e-01	1.53e-01	5.56e-01	6.69e-04	8.14e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	73	5.40e-02	1.19e-01	0.2340	5.82e-02	0.022200	0.159000	-0.010400	0.159000	3.91e-01	7.43e-01	1.86e-02	8.78e-01	1.86e-02
ASPARAGINE N LINKED GLYCOSYLATION	281	7.53e-07	8.74e-06	0.2340	-7.82e-03	0.127000	-0.015100	0.191000	-0.042800	8.22e-01	2.69e-04	6.64e-01	4.00e-08	2.18e-01
G ALPHA S SIGNALLING EVENTS	94	3.69e-03	1.43e-02	0.2330	-3.03e-02	0.041000	0.087500	0.049100	0.205000	6.12e-01	4.93e-01	1.43e-01	4.11e-01	6.14e-04
RHO GTPASES ACTIVATE FORMINS	117	1.89e-02	5.24e-02	0.2330	-6.01e-02	0.086600	-0.074900	0.144000	-0.130000	2.62e-01	1.06e-01	1.62e-01	7.37e-03	1.50e-02
SIGNALLING TO RAS	18	8.99e-01	9.21e-01	0.2330	-6.66e-02	-0.143000	0.138000	0.009240	0.102000	6.25e-01	2.95e-01	3.11e-01	9.46e-01	4.55e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	151	6.81e-06	6.42e-05	0.2320	2.52e-02	0.145000	-0.004960	0.099600	0.150000	5.94e-01	2.10e-03	9.16e-01	3.49e-02	1.54e-03
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	38	2.32e-01	3.42e-01	0.2320	4.48e-02	0.077500	0.138000	0.014900	0.164000	6.33e-01	4.09e-01	1.42e-01	8.74e-01	8.11e-02
ION HOMEOSTASIS	47	1.70e-01	2.71e-01	0.2320	-1.74e-01	-0.005900	0.129000	0.063000	0.051800	3.89e-02	9.44e-01	1.25e-01	4.55e-01	5.39e-01
SIGNALING BY INTERLEUKINS	337	2.06e-06	2.21e-05	0.2310	9.41e-02	0.177000	-0.089600	0.064800	-0.031400	3.08e-03	2.75e-08	4.84e-03	4.15e-02	3.23e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	6.66e-01	7.22e-01	0.2300	-4.43e-02	0.059500	0.137000	0.166000	-0.032900	7.59e-01	6.81e-01	3.41e-01	2.50e-01	8.20e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	2.90e-01	4.00e-01	0.2300	9.60e-04	0.094200	-0.083800	0.041900	-0.188000	9.90e-01	2.36e-01	2.92e-01	5.98e-01	1.79e-02
HATS ACETYLATE HISTONES	90	7.34e-02	1.49e-01	0.2300	-1.43e-01	-0.083300	0.143000	-0.000930	0.072800	1.95e-02	1.72e-01	1.93e-02	9.88e-01	2.33e-01
RNA POLYMERASE III TRANSCRIPTION	41	2.97e-01	4.07e-01	0.2300	-8.78e-03	-0.122000	-0.051400	-0.187000	-0.010900	9.23e-01	1.77e-01	5.70e-01	3.83e-02	9.03e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	6.50e-01	7.09e-01	0.2290	1.83e-01	0.019200	0.080900	0.003150	0.111000	1.21e-01	8.71e-01	4.93e-01	9.79e-01	3.48e-01
GENERATION OF SECOND MESSENGER MOLECULES	19	7.98e-01	8.35e-01	0.2290	1.02e-01	0.159000	-0.089800	-0.057200	-0.073000	4.41e-01	2.29e-01	4.98e-01	6.66e-01	5.82e-01
DNA DAMAGE BYPASS	45	3.40e-01	4.44e-01	0.2280	-6.74e-03	0.022800	-0.185000	-0.005530	-0.132000	9.38e-01	7.91e-01	3.22e-02	9.49e-01	1.26e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	7.45e-02	1.50e-01	0.2280	-5.01e-02	-0.011100	0.053100	0.152000	0.153000	5.17e-01	8.86e-01	4.92e-01	4.94e-02	4.80e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS	24	7.35e-01	7.84e-01	0.2280	1.62e-01	0.083800	-0.106000	0.044400	-0.074200	1.71e-01	4.77e-01	3.69e-01	7.06e-01	5.29e-01
DISEASES OF GLYCOSYLATION	121	1.89e-02	5.24e-02	0.2280	5.94e-02	-0.033000	0.164000	0.059000	0.129000	2.59e-01	5.32e-01	1.80e-03	2.63e-01	1.42e-02
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	73	4.30e-02	1.00e-01	0.2270	-1.77e-01	-0.045700	-0.019400	0.120000	-0.055500	8.93e-03	5.00e-01	7.75e-01	7.62e-02	4.12e-01
MITOTIC G2 G2 M PHASES	183	2.09e-03	8.92e-03	0.2260	-1.42e-02	0.040700	-0.132000	-0.010900	-0.178000	7.41e-01	3.43e-01	2.10e-03	7.99e-01	3.23e-05
MEMBRANE TRAFFICKING	572	2.73e-15	1.13e-13	0.2260	-6.26e-02	0.078600	0.021200	0.198000	-0.036900	1.09e-02	1.38e-03	3.88e-01	8.10e-16	1.33e-01
MITOTIC PROMETAPHASE	174	1.72e-04	1.11e-03	0.2260	-1.40e-01	-0.027600	-0.050600	0.096700	-0.136000	1.42e-03	5.31e-01	2.51e-01	2.80e-02	1.95e-03
TRANSCRIPTIONAL REGULATION BY VENTX	35	5.14e-01	6.01e-01	0.2260	8.46e-02	-0.146000	0.071800	-0.093100	0.093200	3.87e-01	1.35e-01	4.62e-01	3.40e-01	3.40e-01
TELOMERE MAINTENANCE	77	5.61e-02	1.21e-01	0.2260	1.34e-01	0.026800	-0.097500	-0.109000	-0.103000	4.18e-02	6.84e-01	1.39e-01	9.75e-02	1.18e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	174	1.38e-03	6.47e-03	0.2250	1.29e-01	0.163000	-0.082100	-0.018600	-0.018200	3.39e-03	2.13e-04	6.22e-02	6.73e-01	6.79e-01
MHC CLASS II ANTIGEN PRESENTATION	101	4.03e-02	9.55e-02	0.2250	-3.86e-02	0.056700	-0.105000	0.138000	-0.125000	5.03e-01	3.25e-01	6.74e-02	1.63e-02	3.05e-02
MICRORNA MIRNA BIOGENESIS	24	7.07e-01	7.58e-01	0.2250	4.06e-02	-0.108000	0.098600	-0.157000	0.051500	7.31e-01	3.59e-01	4.03e-01	1.82e-01	6.62e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	17	9.10e-01	9.30e-01	0.2240	-1.11e-01	-0.142000	0.096000	-0.029800	0.086800	4.27e-01	3.09e-01	4.93e-01	8.32e-01	5.36e-01
CELL CELL JUNCTION ORGANIZATION	47	8.41e-02	1.64e-01	0.2240	-1.92e-01	0.018700	-0.058000	0.094200	0.028000	2.28e-02	8.25e-01	4.91e-01	2.64e-01	7.40e-01
TRNA AMINOACYLATION	42	3.12e-01	4.18e-01	0.2240	7.69e-03	0.042500	-0.063400	0.193000	-0.082900	9.31e-01	6.33e-01	4.77e-01	3.01e-02	3.53e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	40	9.96e-02	1.86e-01	0.2240	-9.69e-02	0.171000	0.023300	0.040700	-0.096000	2.89e-01	6.11e-02	7.98e-01	6.56e-01	2.94e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	4.02e-01	4.98e-01	0.2240	9.25e-02	0.068300	0.097700	0.083800	-0.142000	4.97e-01	6.16e-01	4.73e-01	5.38e-01	2.97e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	90	9.54e-03	3.03e-02	0.2230	-8.64e-02	0.086200	0.061100	0.155000	-0.084100	1.57e-01	1.58e-01	3.17e-01	1.09e-02	1.68e-01
RHO GTPASE CYCLE	421	4.89e-11	1.57e-09	0.2230	-5.04e-02	0.029800	0.131000	0.139000	0.099000	7.70e-02	2.96e-01	4.14e-06	1.05e-06	5.20e-04
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	105	3.03e-04	1.76e-03	0.2230	-8.15e-03	0.120000	0.006200	0.068400	0.174000	8.85e-01	3.37e-02	9.13e-01	2.26e-01	2.06e-03
REGULATION OF LIPID METABOLISM BY PPARALPHA	105	9.23e-02	1.76e-01	0.2220	-2.67e-02	-0.074200	0.169000	0.021400	0.118000	6.37e-01	1.89e-01	2.73e-03	7.05e-01	3.63e-02
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	56	1.44e-01	2.41e-01	0.2220	-6.03e-02	0.083600	0.051000	0.183000	-0.051800	4.35e-01	2.80e-01	5.10e-01	1.79e-02	5.03e-01
METAL ION SLC TRANSPORTERS	24	3.78e-01	4.78e-01	0.2220	4.21e-04	0.151000	0.034400	0.039100	0.154000	9.97e-01	2.00e-01	7.70e-01	7.40e-01	1.91e-01
NGF STIMULATED TRANSCRIPTION	36	1.49e-01	2.47e-01	0.2220	-1.62e-01	0.147000	-0.021000	-0.008060	-0.029000	9.27e-02	1.26e-01	8.28e-01	9.33e-01	7.64e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	6.54e-01	7.12e-01	0.2220	-4.63e-03	-0.094200	-0.032400	-0.085800	-0.178000	9.74e-01	5.02e-01	8.17e-01	5.40e-01	2.03e-01
REGULATION OF FZD BY UBIQUITINATION	19	7.49e-01	7.92e-01	0.2210	7.86e-02	0.166000	-0.071500	0.079300	0.063200	5.53e-01	2.11e-01	5.89e-01	5.50e-01	6.34e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	167	1.88e-04	1.20e-03	0.2210	-6.08e-02	0.079800	0.064700	0.185000	-0.018800	1.76e-01	7.54e-02	1.50e-01	3.67e-05	6.76e-01
METABOLISM OF LIPIDS	600	8.71e-14	3.16e-12	0.2210	7.66e-02	0.117000	0.010600	0.168000	-0.033400	1.43e-03	1.12e-06	6.58e-01	2.77e-12	1.65e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	34	4.67e-01	5.59e-01	0.2210	-1.27e-01	-0.122000	0.100000	0.077500	-0.039000	1.99e-01	2.17e-01	3.11e-01	4.34e-01	6.94e-01
TELOMERE EXTENSION BY TELOMERASE	22	4.27e-01	5.22e-01	0.2200	1.33e-01	-0.163000	0.033200	-0.046900	-0.030100	2.80e-01	1.86e-01	7.87e-01	7.04e-01	8.07e-01
CIRCADIAN CLOCK	68	9.99e-02	1.86e-01	0.2190	-3.32e-04	0.051700	0.126000	0.151000	0.080200	9.96e-01	4.61e-01	7.16e-02	3.19e-02	2.53e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	3.84e-01	4.84e-01	0.2180	2.57e-02	0.005830	-0.190000	-0.069900	-0.078300	7.87e-01	9.51e-01	4.58e-02	4.62e-01	4.10e-01
SIGNALING BY PDGFR IN DISEASE	20	4.23e-01	5.20e-01	0.2180	-1.56e-01	0.142000	-0.027700	0.001060	0.050000	2.28e-01	2.72e-01	8.30e-01	9.93e-01	6.99e-01
SELECTIVE AUTOPHAGY	71	3.10e-01	4.16e-01	0.2180	3.35e-02	0.145000	-0.086600	0.109000	-0.077800	6.25e-01	3.46e-02	2.07e-01	1.11e-01	2.57e-01
SIGNALING BY PDGF	54	1.89e-01	2.92e-01	0.2180	-1.30e-01	-0.051300	0.162000	-0.014900	0.038300	9.75e-02	5.14e-01	3.97e-02	8.50e-01	6.27e-01
METABOLISM OF FAT SOLUBLE VITAMINS	30	5.14e-01	6.01e-01	0.2180	1.35e-01	0.035700	0.020500	0.063600	0.153000	2.00e-01	7.35e-01	8.46e-01	5.46e-01	1.46e-01
SIGNALING BY MET	73	6.58e-02	1.38e-01	0.2180	3.53e-02	0.118000	0.075000	0.150000	0.065800	6.03e-01	8.22e-02	2.68e-01	2.73e-02	3.31e-01
ATTENUATION PHASE	23	6.62e-01	7.18e-01	0.2170	4.55e-02	0.050200	-0.072700	-0.160000	-0.107000	7.06e-01	6.77e-01	5.46e-01	1.84e-01	3.73e-01
M PHASE	334	3.00e-05	2.52e-04	0.2160	-2.70e-02	0.069900	-0.120000	0.073000	-0.147000	3.98e-01	2.87e-02	1.69e-04	2.23e-02	4.39e-06
CELL CELL COMMUNICATION	103	1.14e-02	3.47e-02	0.2150	-4.78e-02	0.062200	0.083700	0.149000	0.105000	4.03e-01	2.76e-01	1.43e-01	9.06e-03	6.51e-02
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	8.21e-01	8.55e-01	0.2150	-1.22e-01	0.044300	-0.061400	0.064600	-0.146000	3.44e-01	7.32e-01	6.35e-01	6.17e-01	2.57e-01
CELLULAR RESPONSE TO HEAT STRESS	94	4.72e-02	1.08e-01	0.2150	-1.15e-01	0.058400	-0.027000	0.143000	-0.091700	5.44e-02	3.28e-01	6.51e-01	1.64e-02	1.25e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	7.42e-01	7.90e-01	0.2150	-1.63e-01	-0.018300	0.057600	0.079900	0.097400	2.31e-01	8.93e-01	6.72e-01	5.58e-01	4.74e-01
EGFR DOWNREGULATION	27	5.34e-01	6.18e-01	0.2140	2.04e-03	0.130000	0.074800	0.153000	0.009120	9.85e-01	2.44e-01	5.01e-01	1.70e-01	9.35e-01
SIGNALING BY NTRK2 TRKB	24	5.47e-01	6.24e-01	0.2140	-5.07e-02	0.062000	0.016700	0.164000	0.109000	6.68e-01	5.99e-01	8.87e-01	1.64e-01	3.54e-01
AMINO ACIDS REGULATE MTORC1	51	4.75e-01	5.66e-01	0.2130	-2.05e-02	0.118000	-0.078200	0.133000	-0.084700	8.01e-01	1.46e-01	3.34e-01	1.01e-01	2.95e-01
PI3K AKT SIGNALING IN CANCER	83	2.18e-02	5.81e-02	0.2120	-3.64e-02	0.069800	0.112000	0.161000	-0.018400	5.67e-01	2.72e-01	7.74e-02	1.13e-02	7.73e-01
UNWINDING OF DNA	12	9.13e-01	9.32e-01	0.2120	-5.67e-02	0.043400	0.008340	0.193000	-0.050200	7.34e-01	7.95e-01	9.60e-01	2.48e-01	7.63e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	139	1.89e-03	8.31e-03	0.2120	-5.80e-02	0.049100	0.063800	0.179000	-0.054400	2.39e-01	3.18e-01	1.95e-01	2.73e-04	2.68e-01
IRAK1 RECRUITS IKK COMPLEX	14	8.59e-01	8.86e-01	0.2120	1.54e-01	0.133000	0.014100	-0.018500	0.054100	3.19e-01	3.89e-01	9.27e-01	9.05e-01	7.26e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	175	1.75e-04	1.12e-03	0.2110	1.07e-01	0.026000	0.001620	-0.172000	0.055300	1.47e-02	5.54e-01	9.71e-01	9.06e-05	2.07e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	7.19e-01	7.69e-01	0.2110	-1.27e-02	0.122000	-0.089600	-0.138000	0.050300	9.32e-01	4.14e-01	5.48e-01	3.54e-01	7.36e-01
ONCOGENIC MAPK SIGNALING	76	1.29e-01	2.23e-01	0.2110	3.83e-02	0.025800	0.106000	0.120000	0.130000	5.64e-01	6.97e-01	1.11e-01	7.09e-02	4.99e-02
MYOGENESIS	25	7.64e-01	8.07e-01	0.2110	-7.24e-02	-0.087400	0.109000	0.112000	0.085200	5.31e-01	4.49e-01	3.47e-01	3.31e-01	4.61e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	64	1.81e-01	2.84e-01	0.2110	4.68e-02	-0.085400	0.086200	-0.160000	0.042300	5.18e-01	2.38e-01	2.33e-01	2.65e-02	5.59e-01
SARS COV INFECTIONS	139	5.13e-03	1.85e-02	0.2100	4.01e-02	0.182000	-0.063500	0.071900	0.018400	4.15e-01	2.16e-04	1.96e-01	1.44e-01	7.08e-01
SIGNALING BY FGFR2	61	3.39e-01	4.44e-01	0.2100	1.28e-01	0.121000	-0.082900	-0.022700	-0.077500	8.50e-02	1.03e-01	2.63e-01	7.59e-01	2.95e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	3.05e-01	4.14e-01	0.2100	-8.84e-02	0.163000	0.014700	0.036800	0.089100	4.35e-01	1.50e-01	8.97e-01	7.45e-01	4.32e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	81	3.50e-03	1.37e-02	0.2100	5.47e-03	0.120000	-0.046500	0.047600	0.159000	9.32e-01	6.30e-02	4.70e-01	4.59e-01	1.36e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	3.19e-01	4.24e-01	0.2080	2.52e-02	0.107000	-0.052000	0.098800	-0.137000	7.31e-01	1.44e-01	4.79e-01	1.79e-01	6.19e-02
SENSORY PROCESSING OF SOUND	58	9.76e-02	1.83e-01	0.2080	-6.96e-02	0.035600	0.131000	-0.027000	0.140000	3.60e-01	6.39e-01	8.55e-02	7.22e-01	6.57e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	7.01e-01	7.55e-01	0.2080	-5.99e-02	0.044200	-0.117000	-0.012200	0.155000	7.43e-01	8.09e-01	5.23e-01	9.47e-01	3.95e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	87	4.37e-02	1.01e-01	0.2080	-4.03e-02	-0.051400	-0.070000	-0.070000	-0.171000	5.16e-01	4.08e-01	2.59e-01	2.59e-01	6.00e-03
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	337	3.55e-04	2.01e-03	0.2080	5.22e-02	0.121000	-0.102000	0.063400	-0.107000	1.00e-01	1.47e-04	1.39e-03	4.60e-02	7.34e-04
SIGNALING BY ERBB4	56	1.92e-01	2.95e-01	0.2070	7.46e-02	0.161000	-0.065700	0.048200	0.068700	3.34e-01	3.67e-02	3.96e-01	5.33e-01	3.74e-01
TOLL LIKE RECEPTOR CASCADES	136	1.02e-02	3.20e-02	0.2070	7.38e-03	0.152000	-0.014600	0.114000	-0.081700	8.82e-01	2.28e-03	7.69e-01	2.23e-02	1.00e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	55	2.04e-01	3.09e-01	0.2070	5.62e-02	0.013600	0.148000	-0.051900	0.121000	4.71e-01	8.62e-01	5.69e-02	5.06e-01	1.20e-01
ERBB2 REGULATES CELL MOTILITY	13	8.38e-01	8.69e-01	0.2060	1.12e-01	0.061000	0.089400	0.130000	-0.036100	4.83e-01	7.03e-01	5.77e-01	4.17e-01	8.22e-01
MITOTIC PROPHASE	91	4.33e-02	1.01e-01	0.2060	-1.63e-01	0.054600	-0.013100	0.094300	-0.062300	7.21e-03	3.68e-01	8.29e-01	1.20e-01	3.05e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	6.43e-01	7.05e-01	0.2060	5.77e-03	-0.097100	-0.015900	-0.176000	-0.039700	9.58e-01	3.74e-01	8.84e-01	1.06e-01	7.16e-01
NUCLEAR SIGNALING BY ERBB4	30	6.39e-01	7.02e-01	0.2060	1.15e-01	0.077600	0.073800	0.093100	0.095300	2.77e-01	4.62e-01	4.84e-01	3.78e-01	3.66e-01
HEDGEHOG OFF STATE	106	1.05e-01	1.93e-01	0.2060	1.39e-01	0.124000	-0.064500	0.056500	-0.016700	1.34e-02	2.76e-02	2.52e-01	3.15e-01	7.66e-01
L1CAM INTERACTIONS	107	1.99e-02	5.46e-02	0.2060	-1.16e-01	0.000510	0.099600	0.074100	0.116000	3.82e-02	9.93e-01	7.54e-02	1.86e-01	3.89e-02
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	2.45e-01	3.56e-01	0.2050	-1.11e-02	0.126000	-0.089000	0.021800	-0.133000	8.62e-01	4.77e-02	1.61e-01	7.31e-01	3.69e-02
SNRNP ASSEMBLY	51	3.00e-01	4.10e-01	0.2050	-1.60e-01	-0.022000	-0.006020	0.104000	-0.070000	4.81e-02	7.86e-01	9.41e-01	1.99e-01	3.87e-01
TRNA PROCESSING	105	9.52e-03	3.03e-02	0.2040	-1.02e-01	-0.113000	0.000889	0.020900	-0.134000	7.06e-02	4.47e-02	9.87e-01	7.12e-01	1.77e-02
SIGNALING BY BRAF AND RAF FUSIONS	60	3.34e-01	4.38e-01	0.2040	-2.34e-02	-0.018200	0.125000	0.103000	0.120000	7.54e-01	8.08e-01	9.44e-02	1.66e-01	1.07e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	184	5.89e-04	3.16e-03	0.2040	-3.45e-02	0.037500	0.020600	0.196000	-0.012200	4.20e-01	3.81e-01	6.30e-01	4.65e-06	7.76e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	20	7.96e-01	8.35e-01	0.2040	5.40e-02	0.034700	0.146000	0.079000	0.098700	6.76e-01	7.88e-01	2.58e-01	5.41e-01	4.45e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	100	3.46e-02	8.37e-02	0.2030	1.41e-02	0.054900	0.069400	0.182000	-0.008240	8.07e-01	3.43e-01	2.31e-01	1.63e-03	8.87e-01
SHC1 EVENTS IN ERBB4 SIGNALING	12	9.64e-01	9.69e-01	0.2030	4.41e-02	0.129000	-0.071300	0.042900	-0.125000	7.91e-01	4.39e-01	6.69e-01	7.97e-01	4.52e-01
UB SPECIFIC PROCESSING PROTEASES	164	1.82e-02	5.07e-02	0.2030	1.32e-02	0.162000	-0.078000	0.054300	-0.075700	7.70e-01	3.44e-04	8.52e-02	2.31e-01	9.48e-02
SIGNALING BY HEDGEHOG	141	1.14e-02	3.47e-02	0.2030	1.11e-01	0.088400	-0.010200	0.136000	0.047300	2.28e-02	7.03e-02	8.34e-01	5.27e-03	3.33e-01
COPII MEDIATED VESICLE TRANSPORT	64	1.22e-01	2.15e-01	0.2020	-5.10e-02	0.104000	0.044300	0.142000	-0.074400	4.81e-01	1.51e-01	5.40e-01	4.98e-02	3.04e-01
VESICLE MEDIATED TRANSPORT	600	1.19e-12	4.17e-11	0.2020	-6.06e-02	0.073300	0.014700	0.175000	-0.033700	1.17e-02	2.27e-03	5.40e-01	3.52e-13	1.60e-01
SIGNALING BY PTK6	49	2.86e-01	3.97e-01	0.2020	7.72e-02	0.151000	0.040900	0.097600	0.027100	3.50e-01	6.74e-02	6.21e-01	2.38e-01	7.43e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	3.92e-01	4.90e-01	0.2020	4.71e-02	0.085600	0.111000	0.110000	0.082300	6.02e-01	3.43e-01	2.20e-01	2.23e-01	3.62e-01
DISEASES OF METABOLISM	193	8.23e-04	4.21e-03	0.2010	1.34e-01	0.060700	0.082400	0.064700	0.087300	1.30e-03	1.46e-01	4.87e-02	1.22e-01	3.67e-02
RHO GTPASES ACTIVATE IQGAPS	23	7.91e-01	8.31e-01	0.2000	1.04e-02	0.111000	-0.033000	0.076900	-0.144000	9.31e-01	3.58e-01	7.84e-01	5.23e-01	2.33e-01
SIGNALLING TO ERKS	32	5.86e-01	6.57e-01	0.2000	-1.17e-01	0.037100	0.035400	0.150000	-0.030000	2.51e-01	7.16e-01	7.29e-01	1.41e-01	7.69e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	2.81e-01	3.91e-01	0.1980	8.53e-02	-0.028100	-0.008260	0.086100	-0.154000	3.90e-01	7.77e-01	9.34e-01	3.85e-01	1.20e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	102	2.63e-02	6.73e-02	0.1980	1.40e-01	-0.054800	0.011400	-0.128000	0.011400	1.50e-02	3.40e-01	8.43e-01	2.51e-02	8.43e-01
CELL CYCLE MITOTIC	467	4.06e-06	4.10e-05	0.1980	-2.42e-02	0.066400	-0.107000	0.071200	-0.132000	3.72e-01	1.43e-02	7.66e-05	8.67e-03	1.03e-06
RECYCLING PATHWAY OF L1	40	4.36e-01	5.29e-01	0.1980	-4.69e-02	0.094700	0.053800	0.157000	-0.017400	6.08e-01	3.00e-01	5.56e-01	8.58e-02	8.49e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	1.80e-01	2.83e-01	0.1970	1.36e-01	-0.067800	0.027800	-0.122000	0.006060	7.06e-02	3.68e-01	7.12e-01	1.06e-01	9.36e-01
MET PROMOTES CELL MOTILITY	38	5.53e-01	6.28e-01	0.1970	-1.70e-02	0.013400	0.120000	0.142000	0.060600	8.56e-01	8.86e-01	2.00e-01	1.30e-01	5.18e-01
RAC3 GTPASE CYCLE	88	1.03e-01	1.91e-01	0.1960	4.53e-02	0.058800	0.044600	0.166000	0.056500	4.63e-01	3.40e-01	4.70e-01	6.98e-03	3.60e-01
P75NTR SIGNALS VIA NF KB	16	8.01e-01	8.37e-01	0.1960	1.42e-01	0.082000	0.065300	-0.068300	0.051900	3.27e-01	5.70e-01	6.51e-01	6.36e-01	7.19e-01
REPRODUCTION	73	8.81e-02	1.70e-01	0.1960	-9.19e-02	-0.064000	-0.103000	-0.123000	-0.008080	1.75e-01	3.45e-01	1.28e-01	6.94e-02	9.05e-01
MYD88 INDEPENDENT TLR4 CASCADE	92	6.10e-02	1.29e-01	0.1950	1.14e-02	0.093600	0.036600	0.153000	-0.067500	8.51e-01	1.21e-01	5.45e-01	1.12e-02	2.64e-01
ADAPTIVE IMMUNE SYSTEM	582	6.03e-07	7.21e-06	0.1950	3.93e-02	0.130000	-0.076500	0.085000	-0.081900	1.07e-01	9.76e-08	1.71e-03	4.93e-04	7.80e-04
DUAL INCISION IN TC NER	64	3.79e-01	4.79e-01	0.1950	5.21e-02	0.095800	-0.090400	-0.052700	-0.124000	4.71e-01	1.85e-01	2.11e-01	4.66e-01	8.72e-02
NONHOMOLOGOUS END JOINING NHEJ	42	5.27e-01	6.13e-01	0.1950	-9.06e-02	-0.021400	-0.067500	-0.029800	-0.155000	3.10e-01	8.10e-01	4.49e-01	7.38e-01	8.25e-02
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	6.41e-01	7.03e-01	0.1950	-4.97e-02	0.136000	0.098400	-0.039700	0.075100	7.47e-01	3.77e-01	5.24e-01	7.97e-01	6.27e-01
SIGNALING BY KIT IN DISEASE	20	7.77e-01	8.18e-01	0.1950	-6.91e-02	0.115000	-0.083900	0.113000	0.004140	5.93e-01	3.73e-01	5.16e-01	3.81e-01	9.74e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	2.90e-01	4.00e-01	0.1950	-6.94e-02	-0.141000	0.043200	-0.094600	-0.048300	3.48e-01	5.69e-02	5.60e-01	2.02e-01	5.14e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	2.63e-01	3.72e-01	0.1950	8.86e-03	0.104000	-0.074500	-0.001930	-0.146000	8.93e-01	1.14e-01	2.59e-01	9.77e-01	2.67e-02
HIV LIFE CYCLE	142	5.83e-02	1.26e-01	0.1940	-7.49e-02	0.072500	-0.083500	0.051500	-0.131000	1.24e-01	1.36e-01	8.63e-02	2.90e-01	7.01e-03
SIGNALING BY WNT	261	2.73e-04	1.62e-03	0.1940	9.88e-02	0.151000	-0.071100	0.003750	0.011300	6.08e-03	2.84e-05	4.86e-02	9.17e-01	7.54e-01
DISEASES OF PROGRAMMED CELL DEATH	53	3.91e-01	4.89e-01	0.1940	6.78e-02	0.060200	-0.085300	-0.128000	-0.076400	3.94e-01	4.48e-01	2.83e-01	1.07e-01	3.36e-01
RHOD GTPASE CYCLE	50	2.99e-01	4.09e-01	0.1940	-5.49e-02	0.013900	0.031000	0.172000	0.062000	5.02e-01	8.65e-01	7.04e-01	3.56e-02	4.49e-01
HOMOLOGY DIRECTED REPAIR	105	2.31e-02	6.09e-02	0.1940	-5.09e-02	-0.051400	-0.038600	-0.061200	-0.164000	3.68e-01	3.63e-01	4.95e-01	2.79e-01	3.66e-03
HCMV EARLY EVENTS	78	2.53e-01	3.62e-01	0.1930	-1.11e-01	-0.086700	0.120000	0.052600	0.019600	8.97e-02	1.86e-01	6.79e-02	4.22e-01	7.65e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	28	3.81e-01	4.81e-01	0.1920	-6.32e-02	0.107000	-0.022700	-0.141000	0.030000	5.63e-01	3.26e-01	8.36e-01	1.97e-01	7.84e-01
GOLGI TO ER RETROGRADE TRANSPORT	118	2.55e-02	6.58e-02	0.1920	-1.80e-02	0.023000	0.004810	0.186000	-0.036900	7.35e-01	6.67e-01	9.28e-01	5.02e-04	4.89e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	7.81e-01	8.21e-01	0.1890	1.40e-01	0.050400	-0.051800	0.079700	-0.067100	2.24e-01	6.63e-01	6.54e-01	4.90e-01	5.61e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	5.37e-03	1.92e-02	0.1890	1.31e-02	0.083400	-0.137000	-0.062200	-0.077300	7.29e-01	2.73e-02	2.95e-04	9.95e-02	4.08e-02
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	62	3.45e-01	4.49e-01	0.1880	1.23e-01	0.059600	-0.072500	-0.087100	-0.060600	9.28e-02	4.18e-01	3.24e-01	2.36e-01	4.10e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	15	6.86e-01	7.41e-01	0.1870	-2.54e-02	0.066100	-0.118000	-0.056900	0.112000	8.65e-01	6.58e-01	4.27e-01	7.03e-01	4.53e-01
MITOCHONDRIAL BIOGENESIS	92	2.56e-02	6.59e-02	0.1860	7.70e-02	0.054300	-0.022200	-0.032400	-0.156000	2.02e-01	3.69e-01	7.13e-01	5.91e-01	9.86e-03
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	7.51e-01	7.94e-01	0.1830	4.38e-02	-0.089900	-0.032600	-0.037200	-0.145000	7.54e-01	5.21e-01	8.16e-01	7.91e-01	3.00e-01
TRANSCRIPTION OF THE HIV GENOME	67	4.34e-01	5.28e-01	0.1830	1.86e-02	0.060400	-0.088100	-0.032500	-0.144000	7.92e-01	3.93e-01	2.13e-01	6.45e-01	4.18e-02
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	8.86e-01	9.09e-01	0.1820	-7.47e-02	0.105000	0.073600	0.079400	0.069700	6.54e-01	5.31e-01	6.59e-01	6.34e-01	6.76e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	4.48e-01	5.41e-01	0.1820	-7.45e-03	-0.047300	0.160000	-0.057700	0.040500	9.33e-01	5.96e-01	7.24e-02	5.18e-01	6.50e-01
MAP2K AND MAPK ACTIVATION	36	6.36e-01	7.01e-01	0.1810	1.04e-01	0.055100	0.085200	0.007550	0.108000	2.78e-01	5.68e-01	3.77e-01	9.38e-01	2.63e-01
DNA DAMAGE RECOGNITION IN GG NER	38	5.79e-01	6.50e-01	0.1810	-8.18e-02	0.127000	-0.038100	0.040000	-0.083200	3.83e-01	1.75e-01	6.84e-01	6.70e-01	3.75e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	9.31e-01	9.44e-01	0.1810	1.35e-01	0.091200	-0.000932	-0.067900	0.039600	3.98e-01	5.69e-01	9.95e-01	6.72e-01	8.05e-01
SIGNALING BY FGFR IN DISEASE	54	3.10e-01	4.16e-01	0.1810	-2.46e-02	0.153000	-0.046400	-0.016700	-0.080400	7.54e-01	5.25e-02	5.56e-01	8.32e-01	3.07e-01
FLT3 SIGNALING IN DISEASE	27	4.44e-01	5.38e-01	0.1810	3.94e-02	-0.006210	-0.041300	0.018800	0.171000	7.23e-01	9.55e-01	7.11e-01	8.66e-01	1.25e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	42	5.22e-01	6.09e-01	0.1800	-1.12e-01	-0.076400	-0.080400	-0.072100	-0.049700	2.08e-01	3.92e-01	3.68e-01	4.19e-01	5.78e-01
GENE SILENCING BY RNA	79	2.98e-01	4.09e-01	0.1800	-1.26e-01	-0.074000	0.067200	-0.080800	0.014500	5.36e-02	2.56e-01	3.02e-01	2.15e-01	8.24e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	14	8.12e-01	8.48e-01	0.1800	-1.85e-02	0.005300	-0.170000	-0.054600	0.013700	9.05e-01	9.73e-01	2.71e-01	7.23e-01	9.29e-01
HEMOSTASIS	463	1.84e-09	4.18e-08	0.1800	1.09e-02	0.132000	0.016100	0.102000	0.066000	6.90e-01	1.35e-06	5.55e-01	1.92e-04	1.53e-02
INTRINSIC PATHWAY FOR APOPTOSIS	50	5.96e-01	6.67e-01	0.1800	-7.55e-02	0.087000	-0.115000	0.015100	-0.074700	3.56e-01	2.87e-01	1.60e-01	8.54e-01	3.61e-01
SIGNALING BY ERBB2	47	5.60e-01	6.32e-01	0.1790	2.96e-02	0.154000	-0.029300	0.060100	-0.056100	7.25e-01	6.81e-02	7.29e-01	4.76e-01	5.06e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	280	5.69e-03	2.01e-02	0.1790	-6.19e-03	0.091000	-0.069400	0.066900	-0.120000	8.59e-01	8.94e-03	4.61e-02	5.47e-02	5.57e-04
SODIUM CALCIUM EXCHANGERS	10	9.39e-01	9.49e-01	0.1790	-7.99e-02	0.072600	0.093400	0.077800	0.074700	6.62e-01	6.91e-01	6.09e-01	6.70e-01	6.82e-01
SEMAPHORIN INTERACTIONS	64	6.22e-01	6.90e-01	0.1780	-1.98e-02	-0.067500	0.111000	-0.051600	0.108000	7.84e-01	3.51e-01	1.26e-01	4.76e-01	1.34e-01
ION CHANNEL TRANSPORT	135	1.47e-01	2.45e-01	0.1770	-3.99e-02	-0.066100	0.130000	0.053700	0.076000	4.24e-01	1.85e-01	9.24e-03	2.82e-01	1.28e-01
HIV TRANSCRIPTION ELONGATION	42	5.26e-01	6.12e-01	0.1770	2.50e-02	-0.004630	-0.042900	-0.147000	-0.085500	7.79e-01	9.59e-01	6.31e-01	1.00e-01	3.38e-01
ACYL CHAIN REMODELLING OF PS	14	7.48e-01	7.92e-01	0.1770	8.36e-02	-0.027300	0.127000	0.043400	-0.075000	5.88e-01	8.60e-01	4.12e-01	7.78e-01	6.27e-01
STRIATED MUSCLE CONTRACTION	22	8.20e-01	8.54e-01	0.1760	9.95e-02	-0.015100	-0.107000	-0.095400	-0.018500	4.19e-01	9.02e-01	3.83e-01	4.39e-01	8.81e-01
CELL CYCLE	582	1.87e-06	2.03e-05	0.1760	-1.74e-02	0.040200	-0.101000	0.045300	-0.129000	4.76e-01	9.96e-02	3.18e-05	6.30e-02	1.13e-07
SIGNAL TRANSDUCTION BY L1	21	8.33e-01	8.66e-01	0.1760	-5.10e-02	0.115000	0.017400	0.121000	0.005950	6.86e-01	3.60e-01	8.90e-01	3.36e-01	9.62e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	27	7.17e-01	7.67e-01	0.1760	2.77e-02	-0.052300	-0.057400	-0.138000	0.071300	8.04e-01	6.38e-01	6.06e-01	2.15e-01	5.22e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	40	3.92e-01	4.89e-01	0.1750	4.04e-02	-0.092900	0.038100	0.130000	0.044100	6.59e-01	3.10e-01	6.77e-01	1.54e-01	6.29e-01
LEISHMANIA INFECTION	182	9.16e-04	4.60e-03	0.1750	5.73e-03	0.135000	0.012600	0.079800	0.076100	8.94e-01	1.72e-03	7.69e-01	6.37e-02	7.70e-02
METABOLISM OF STEROIDS	109	1.68e-01	2.69e-01	0.1750	4.87e-02	0.092200	-0.049100	0.131000	-0.005370	3.81e-01	9.66e-02	3.76e-01	1.83e-02	9.23e-01
ENDOGENOUS STEROLS	20	9.14e-01	9.32e-01	0.1750	1.43e-01	0.085500	-0.044200	-0.028700	-0.002600	2.69e-01	5.08e-01	7.32e-01	8.24e-01	9.84e-01
SIGNALING BY FGFR	71	5.16e-01	6.04e-01	0.1740	9.97e-02	0.114000	-0.064200	0.008110	-0.055100	1.47e-01	9.75e-02	3.50e-01	9.06e-01	4.22e-01
NICOTINATE METABOLISM	24	5.50e-01	6.26e-01	0.1730	-1.34e-03	-0.052200	0.097800	0.069700	-0.113000	9.91e-01	6.58e-01	4.07e-01	5.54e-01	3.36e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	7.31e-01	7.80e-01	0.1730	-2.56e-02	-0.025100	0.167000	0.022700	0.013700	8.32e-01	8.35e-01	1.65e-01	8.51e-01	9.10e-01
TRANSPORT OF SMALL MOLECULES	552	2.40e-08	3.76e-07	0.1720	3.57e-02	0.109000	0.007440	0.120000	0.044500	1.54e-01	1.27e-05	7.66e-01	1.51e-06	7.54e-02
SIGNALING BY ACTIVIN	12	9.60e-01	9.67e-01	0.1720	-5.02e-02	0.033800	0.073000	0.139000	0.035800	7.63e-01	8.40e-01	6.62e-01	4.06e-01	8.30e-01
CARGO CONCENTRATION IN THE ER	30	6.44e-01	7.05e-01	0.1700	-5.15e-02	0.095400	0.068400	0.111000	-0.016800	6.26e-01	3.66e-01	5.17e-01	2.93e-01	8.73e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	619	3.03e-10	8.79e-09	0.1700	-4.56e-02	0.050700	0.080700	0.125000	0.046000	5.38e-02	3.23e-02	6.52e-04	1.15e-07	5.19e-02
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	3.51e-01	4.55e-01	0.1700	1.60e-01	-0.042600	0.031800	-0.018100	-0.014500	5.77e-02	6.14e-01	7.06e-01	8.30e-01	8.63e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1185	8.13e-15	3.25e-13	0.1700	-2.92e-02	0.089300	-0.021200	0.129000	-0.053400	9.43e-02	3.04e-07	2.24e-01	1.07e-13	2.19e-03
OXIDATIVE STRESS INDUCED SENESCENCE	77	4.44e-01	5.38e-01	0.1700	-1.76e-02	-0.083300	0.092300	-0.104000	0.046000	7.90e-01	2.07e-01	1.62e-01	1.14e-01	4.85e-01
APOPTOTIC EXECUTION PHASE	44	5.70e-01	6.43e-01	0.1690	2.26e-03	0.067000	-0.152000	0.014400	-0.028400	9.79e-01	4.42e-01	8.08e-02	8.68e-01	7.44e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	5.03e-01	5.91e-01	0.1690	-5.51e-02	-0.083600	0.133000	0.026700	0.000534	4.84e-01	2.88e-01	8.98e-02	7.34e-01	9.95e-01
SIGNALING BY TGFB FAMILY MEMBERS	96	8.25e-02	1.62e-01	0.1690	-1.22e-02	0.154000	-0.018000	0.063500	0.018100	8.36e-01	9.20e-03	7.61e-01	2.83e-01	7.60e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	92	1.16e-01	2.08e-01	0.1660	-6.53e-02	0.086200	0.035100	0.104000	-0.062700	2.80e-01	1.53e-01	5.61e-01	8.56e-02	2.99e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	33	5.98e-01	6.68e-01	0.1660	8.97e-02	0.043700	-0.046100	0.070000	0.103000	3.73e-01	6.64e-01	6.47e-01	4.86e-01	3.06e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	8.46e-01	8.75e-01	0.1660	4.13e-02	0.037900	-0.090900	0.053700	-0.115000	6.81e-01	7.06e-01	3.66e-01	5.94e-01	2.54e-01
RHO GTPASE EFFECTORS	243	9.55e-03	3.03e-02	0.1650	-1.30e-02	0.118000	-0.031100	0.086400	-0.069400	7.28e-01	1.58e-03	4.04e-01	2.07e-02	6.31e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS	49	5.44e-01	6.23e-01	0.1640	-9.51e-02	0.010000	0.101000	0.068100	0.054000	2.50e-01	9.03e-01	2.22e-01	4.10e-01	5.14e-01
BASE EXCISION REPAIR	55	5.50e-01	6.26e-01	0.1630	6.51e-04	-0.019600	-0.067400	-0.139000	-0.050000	9.93e-01	8.02e-01	3.87e-01	7.49e-02	5.21e-01
SIGNALING BY SCF KIT	41	6.87e-01	7.42e-01	0.1630	1.69e-02	0.004690	0.054800	0.134000	0.073300	8.52e-01	9.59e-01	5.44e-01	1.38e-01	4.17e-01
ESTROGEN DEPENDENT GENE EXPRESSION	99	1.46e-01	2.45e-01	0.1610	1.18e-02	-0.002750	-0.015500	-0.153000	0.048100	8.40e-01	9.62e-01	7.90e-01	8.65e-03	4.09e-01
NUCLEOTIDE EXCISION REPAIR	109	1.78e-01	2.81e-01	0.1610	5.52e-03	0.093600	-0.052000	-0.025300	-0.118000	9.21e-01	9.16e-02	3.49e-01	6.49e-01	3.38e-02
NOD1 2 SIGNALING PATHWAY	34	5.28e-01	6.13e-01	0.1600	1.13e-02	0.039100	0.129000	0.085000	-0.015200	9.09e-01	6.93e-01	1.94e-01	3.91e-01	8.78e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	51	4.68e-01	5.59e-01	0.1600	8.06e-02	0.123000	0.028900	0.050300	-0.022600	3.19e-01	1.28e-01	7.22e-01	5.35e-01	7.80e-01
NUCLEOTIDE SALVAGE	21	7.48e-01	7.92e-01	0.1580	1.08e-01	-0.034500	-0.047300	0.096100	0.027800	3.93e-01	7.84e-01	7.08e-01	4.46e-01	8.25e-01
MEIOSIS	61	2.81e-01	3.91e-01	0.1580	-8.09e-02	-0.045300	-0.110000	-0.064000	-0.013200	2.75e-01	5.41e-01	1.37e-01	3.88e-01	8.59e-01
FLT3 SIGNALING	36	4.55e-01	5.47e-01	0.1570	-2.73e-02	0.001400	-0.013000	0.049600	0.145000	7.77e-01	9.88e-01	8.93e-01	6.07e-01	1.31e-01
MUSCLE CONTRACTION	152	1.60e-02	4.58e-02	0.1570	-1.19e-01	0.003870	0.072400	-0.047400	0.053800	1.16e-02	9.34e-01	1.24e-01	3.14e-01	2.53e-01
PTEN REGULATION	132	3.07e-01	4.15e-01	0.1550	9.67e-02	0.084100	-0.073600	0.000668	-0.047300	5.54e-02	9.56e-02	1.45e-01	9.89e-01	3.49e-01
PLATELET HOMEOSTASIS	76	1.11e-01	2.01e-01	0.1550	-4.06e-02	0.111000	-0.040900	0.046300	0.079100	5.41e-01	9.46e-02	5.37e-01	4.85e-01	2.34e-01
CELL JUNCTION ORGANIZATION	71	3.15e-01	4.20e-01	0.1550	-7.69e-02	0.075100	0.008990	0.108000	0.027000	2.63e-01	2.74e-01	8.96e-01	1.16e-01	6.94e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	1.50e-01	2.48e-01	0.1540	-4.32e-02	0.147000	-0.011700	0.000327	-0.014400	5.27e-01	3.10e-02	8.64e-01	9.96e-01	8.33e-01
DNA DOUBLE STRAND BREAK REPAIR	134	5.44e-02	1.19e-01	0.1530	-5.91e-02	-0.061700	-0.008540	-0.040800	-0.120000	2.38e-01	2.18e-01	8.65e-01	4.15e-01	1.64e-02
DUAL INCISION IN GG NER	40	8.30e-01	8.63e-01	0.1520	-2.30e-02	0.106000	-0.076600	-0.021200	-0.071600	8.02e-01	2.48e-01	4.02e-01	8.17e-01	4.34e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	60	4.49e-01	5.42e-01	0.1520	-1.06e-01	-0.031100	0.087300	-0.056900	-0.001610	1.56e-01	6.77e-01	2.43e-01	4.47e-01	9.83e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	85	2.78e-01	3.88e-01	0.1510	6.38e-03	-0.021100	0.048300	0.142000	0.001220	9.19e-01	7.37e-01	4.42e-01	2.39e-02	9.84e-01
CILIUM ASSEMBLY	189	1.06e-02	3.28e-02	0.1510	-5.07e-02	-0.128000	0.041400	0.044100	-0.016900	2.30e-01	2.45e-03	3.27e-01	2.97e-01	6.89e-01
EXTENSION OF TELOMERES	49	4.89e-01	5.79e-01	0.1510	1.08e-01	-0.019300	-0.056600	0.008100	-0.086700	1.92e-01	8.16e-01	4.93e-01	9.22e-01	2.94e-01
NEGATIVE REGULATION OF FLT3	14	9.51e-01	9.60e-01	0.1500	3.75e-02	-0.114000	0.042200	0.041200	0.068300	8.08e-01	4.60e-01	7.84e-01	7.90e-01	6.58e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	9.55e-01	9.63e-01	0.1490	2.45e-02	-0.027300	0.063400	0.056100	0.116000	8.50e-01	8.33e-01	6.24e-01	6.64e-01	3.67e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	525	3.80e-04	2.13e-03	0.1480	5.00e-02	0.113000	-0.071100	0.039600	-0.012900	5.13e-02	1.09e-05	5.50e-03	1.22e-01	6.15e-01
SIGNALING BY NUCLEAR RECEPTORS	214	1.48e-02	4.29e-02	0.1480	5.62e-02	0.121000	-0.039300	0.023500	0.044100	1.57e-01	2.33e-03	3.23e-01	5.54e-01	2.68e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	7.47e-01	7.92e-01	0.1480	6.66e-02	0.005940	-0.024700	-0.093800	-0.089000	5.08e-01	9.53e-01	8.06e-01	3.51e-01	3.77e-01
HCMV LATE EVENTS	63	5.55e-01	6.29e-01	0.1470	-9.78e-02	0.014300	0.018400	0.092100	-0.055400	1.80e-01	8.44e-01	8.01e-01	2.07e-01	4.47e-01
SENSORY PERCEPTION	132	2.76e-02	6.98e-02	0.1470	-7.40e-03	0.042100	0.006930	-0.085800	0.111000	8.83e-01	4.04e-01	8.91e-01	8.90e-02	2.75e-02
DEUBIQUITINATION	237	3.59e-02	8.63e-02	0.1460	-8.62e-03	0.115000	-0.039700	0.043300	-0.067000	8.20e-01	2.24e-03	2.93e-01	2.52e-01	7.63e-02
DEADENYLATION DEPENDENT MRNA DECAY	55	5.46e-01	6.24e-01	0.1460	-4.55e-02	-0.069600	-0.043600	-0.016400	-0.110000	5.60e-01	3.72e-01	5.76e-01	8.34e-01	1.58e-01
SIGNALING BY NOTCH	187	4.71e-02	1.08e-01	0.1440	1.04e-01	0.053500	0.023500	-0.026800	0.077000	1.46e-02	2.08e-01	5.80e-01	5.28e-01	6.99e-02
INTERFERON GAMMA SIGNALING	71	4.21e-01	5.18e-01	0.1440	6.84e-02	0.000564	-0.077300	-0.094900	0.032100	3.19e-01	9.93e-01	2.60e-01	1.67e-01	6.41e-01
METABOLISM OF VITAMINS AND COFACTORS	147	1.71e-01	2.71e-01	0.1440	5.35e-02	0.074400	0.021400	0.108000	0.012000	2.63e-01	1.20e-01	6.55e-01	2.38e-02	8.02e-01
SURFACTANT METABOLISM	16	9.00e-01	9.21e-01	0.1440	2.86e-02	0.132000	0.005090	-0.035300	0.033000	8.43e-01	3.61e-01	9.72e-01	8.07e-01	8.19e-01
NICOTINAMIDE SALVAGING	15	9.56e-01	9.63e-01	0.1430	-9.52e-02	-0.064400	-0.046700	0.038100	-0.059300	5.23e-01	6.66e-01	7.54e-01	7.98e-01	6.91e-01
VISUAL PHOTOTRANSDUCTION	55	5.42e-01	6.23e-01	0.1430	5.91e-02	0.019500	-0.014000	-0.061200	0.112000	4.48e-01	8.02e-01	8.57e-01	4.32e-01	1.51e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	358	1.11e-03	5.50e-03	0.1420	4.64e-02	0.094000	0.029200	0.088400	0.023400	1.33e-01	2.32e-03	3.44e-01	4.16e-03	4.48e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	4.95e-01	5.85e-01	0.1420	-1.03e-01	0.069500	0.050200	0.014400	0.044500	2.41e-01	4.31e-01	5.69e-01	8.71e-01	6.13e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	4.85e-01	5.75e-01	0.1420	-4.07e-02	-0.051100	-0.055200	-0.043300	-0.105000	5.45e-01	4.47e-01	4.12e-01	5.20e-01	1.20e-01
EPH EPHRIN SIGNALING	90	3.31e-01	4.35e-01	0.1420	-1.54e-02	0.104000	0.015400	0.093300	0.008170	8.00e-01	8.88e-02	8.01e-01	1.26e-01	8.94e-01
METABOLISM OF FOLATE AND PTERINES	15	8.60e-01	8.87e-01	0.1410	6.22e-02	0.036900	0.074900	0.034700	-0.087900	6.77e-01	8.05e-01	6.15e-01	8.16e-01	5.56e-01
FANCONI ANEMIA PATHWAY	36	7.98e-01	8.35e-01	0.1400	-3.14e-02	-0.111000	0.060100	-0.033100	-0.042400	7.44e-01	2.51e-01	5.33e-01	7.31e-01	6.60e-01
ZINC TRANSPORTERS	15	9.19e-01	9.36e-01	0.1400	-3.42e-03	0.100000	-0.059300	0.014300	0.077300	9.82e-01	5.02e-01	6.91e-01	9.23e-01	6.04e-01
POLO LIKE KINASE MEDIATED EVENTS	13	9.24e-01	9.40e-01	0.1390	8.80e-02	0.068200	0.037000	-0.041700	-0.061800	5.83e-01	6.70e-01	8.17e-01	7.94e-01	6.99e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	63	6.47e-01	7.07e-01	0.1390	8.64e-02	0.085100	-0.046100	0.013800	0.046700	2.36e-01	2.43e-01	5.27e-01	8.50e-01	5.22e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	274	5.96e-03	2.08e-02	0.1380	-1.76e-02	0.081700	0.033500	0.103000	-0.017500	6.17e-01	2.03e-02	3.41e-01	3.34e-03	6.19e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	452	1.50e-05	1.35e-04	0.1370	-3.56e-02	0.076200	0.053600	0.094000	0.007420	1.96e-01	5.69e-03	5.16e-02	6.42e-04	7.88e-01
DOWNREGULATION OF ERBB2 SIGNALING	27	7.44e-01	7.91e-01	0.1350	-1.79e-03	0.125000	0.026200	0.004640	-0.043400	9.87e-01	2.60e-01	8.13e-01	9.67e-01	6.96e-01
GRB2 EVENTS IN ERBB2 SIGNALING	14	9.87e-01	9.90e-01	0.1340	5.04e-02	0.050000	-0.057100	-0.036000	-0.092100	7.44e-01	7.46e-01	7.11e-01	8.16e-01	5.51e-01
SIGNALING BY ERBB2 IN CANCER	24	9.14e-01	9.32e-01	0.1340	3.37e-03	0.130000	-0.028000	0.017100	-0.008460	9.77e-01	2.71e-01	8.12e-01	8.84e-01	9.43e-01
MAPK FAMILY SIGNALING CASCADES	281	2.94e-03	1.21e-02	0.1340	2.34e-02	0.107000	0.031500	0.068700	-0.012800	5.00e-01	2.02e-03	3.65e-01	4.80e-02	7.12e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	6.62e-01	7.18e-01	0.1340	-5.06e-02	-0.064300	0.065500	0.045900	-0.069200	5.57e-01	4.56e-01	4.47e-01	5.94e-01	4.22e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	5.47e-01	6.24e-01	0.1330	-1.08e-01	-0.042200	0.055400	0.004000	-0.033300	9.61e-02	5.17e-01	3.95e-01	9.51e-01	6.09e-01
OTHER INTERLEUKIN SIGNALING	19	9.43e-01	9.53e-01	0.1280	2.06e-02	-0.002670	0.008280	-0.011000	0.126000	8.77e-01	9.84e-01	9.50e-01	9.34e-01	3.42e-01
RESOLUTION OF ABASIC SITES AP SITES	37	9.04e-01	9.25e-01	0.1280	-3.78e-02	-0.027200	-0.066500	-0.076800	-0.062200	6.91e-01	7.75e-01	4.84e-01	4.19e-01	5.13e-01
NERVOUS SYSTEM DEVELOPMENT	541	6.19e-06	5.98e-05	0.1280	5.51e-02	0.085500	-0.022700	-0.047700	0.056100	2.91e-02	7.14e-04	3.68e-01	5.87e-02	2.63e-02
DEVELOPMENTAL BIOLOGY	792	3.91e-09	7.57e-08	0.1260	4.60e-02	0.064100	0.021500	-0.050500	0.081700	2.87e-02	2.34e-03	3.08e-01	1.65e-02	1.04e-04
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	22	8.42e-01	8.72e-01	0.1260	-8.31e-02	0.050200	-0.044800	0.005650	0.066500	5.00e-01	6.83e-01	7.16e-01	9.63e-01	5.89e-01
DNA REPAIR	288	7.31e-03	2.44e-02	0.1260	-4.49e-02	-0.072700	-0.000372	-0.035700	-0.085500	1.91e-01	3.41e-02	9.91e-01	2.99e-01	1.28e-02
PI3K EVENTS IN ERBB2 SIGNALING	14	9.79e-01	9.82e-01	0.1250	-6.80e-02	0.035200	0.062700	0.075600	0.014900	6.60e-01	8.20e-01	6.85e-01	6.24e-01	9.23e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	7.43e-01	7.90e-01	0.1250	-1.99e-02	0.114000	-0.008960	0.013500	0.043300	8.36e-01	2.35e-01	9.26e-01	8.88e-01	6.53e-01
ESR MEDIATED SIGNALING	160	1.73e-01	2.74e-01	0.1240	4.20e-02	0.106000	-0.042400	-0.020000	0.015600	3.60e-01	2.13e-02	3.56e-01	6.63e-01	7.34e-01
REGULATION OF TP53 ACTIVITY	148	2.36e-01	3.46e-01	0.1210	-6.63e-02	-0.039800	0.055000	0.066700	-0.035700	1.65e-01	4.04e-01	2.48e-01	1.62e-01	4.53e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	8.82e-01	9.06e-01	0.1200	1.92e-02	0.062200	0.043200	0.004480	0.091000	8.53e-01	5.49e-01	6.77e-01	9.66e-01	3.80e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	35	7.78e-01	8.19e-01	0.1180	-5.19e-03	0.006310	0.009990	-0.051600	-0.106000	9.58e-01	9.48e-01	9.19e-01	5.98e-01	2.79e-01
REGULATION OF PTEN GENE TRANSCRIPTION	57	8.65e-01	8.91e-01	0.1140	-5.81e-02	-0.058800	0.065000	0.045100	-0.001180	4.48e-01	4.43e-01	3.96e-01	5.56e-01	9.88e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	9.32e-01	9.44e-01	0.1130	2.18e-02	-0.045900	-0.065100	0.055300	-0.054700	8.70e-01	7.29e-01	6.23e-01	6.77e-01	6.80e-01
POTENTIAL THERAPEUTICS FOR SARS	76	4.26e-01	5.22e-01	0.1130	-5.45e-03	0.091300	-0.017400	-0.009510	0.063400	9.35e-01	1.69e-01	7.93e-01	8.86e-01	3.40e-01
HCMV INFECTION	101	5.31e-01	6.15e-01	0.1130	-4.11e-02	-0.020500	0.034800	0.092000	-0.031700	4.76e-01	7.22e-01	5.46e-01	1.11e-01	5.82e-01
SHC1 EVENTS IN ERBB2 SIGNALING	20	9.66e-01	9.71e-01	0.1120	6.36e-02	0.018100	0.034300	0.076600	-0.033200	6.22e-01	8.89e-01	7.91e-01	5.53e-01	7.97e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	9.63e-01	9.68e-01	0.1060	2.28e-02	0.075300	0.022700	0.065800	-0.013000	8.35e-01	4.90e-01	8.35e-01	5.47e-01	9.05e-01
SUMOYLATION	158	4.65e-01	5.57e-01	0.1020	-9.01e-02	-0.014200	0.033300	0.030900	0.003660	5.11e-02	7.59e-01	4.71e-01	5.03e-01	9.37e-01
CELLULAR SENESCENCE	140	7.93e-01	8.33e-01	0.1010	-3.16e-02	-0.069300	0.056100	-0.018800	0.029300	5.19e-01	1.57e-01	2.53e-01	7.01e-01	5.49e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	8.95e-01	9.18e-01	0.0990	2.60e-02	-0.017400	-0.024700	-0.086900	-0.026000	7.35e-01	8.21e-01	7.47e-01	2.57e-01	7.35e-01
MEIOTIC SYNAPSIS	38	9.29e-01	9.43e-01	0.0988	-6.54e-02	-0.029200	-0.012700	-0.050600	0.043800	4.86e-01	7.55e-01	8.92e-01	5.90e-01	6.40e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	281	2.46e-02	6.39e-02	0.0977	-8.82e-03	-0.068600	0.020700	0.019100	-0.063100	8.00e-01	4.84e-02	5.52e-01	5.83e-01	6.95e-02
P38MAPK EVENTS	12	9.98e-01	9.98e-01	0.0967	-6.46e-02	-0.052200	0.022900	0.009990	0.042900	6.98e-01	7.54e-01	8.91e-01	9.52e-01	7.97e-01
TRANSCRIPTIONAL REGULATION BY TP53	338	1.28e-01	2.22e-01	0.0922	-3.27e-02	-0.001480	-0.020800	-0.021600	-0.080800	3.03e-01	9.63e-01	5.13e-01	4.95e-01	1.09e-02
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	9.92e-01	9.93e-01	0.0905	2.37e-02	-0.011600	0.029200	0.009630	0.080900	8.44e-01	9.23e-01	8.09e-01	9.36e-01	5.02e-01
AGGREPHAGY	34	9.91e-01	9.93e-01	0.0867	-7.54e-03	0.016300	-0.065900	-0.019900	-0.049500	9.39e-01	8.69e-01	5.06e-01	8.41e-01	6.18e-01
RNA POLYMERASE II TRANSCRIPTION	1070	3.41e-03	1.35e-02	0.0848	-2.40e-02	-0.002320	-0.038600	-0.035400	-0.062300	1.90e-01	8.99e-01	3.48e-02	5.31e-02	6.55e-04
HSF1 DEPENDENT TRANSACTIVATION	33	9.27e-01	9.41e-01	0.0770	3.54e-02	0.026800	0.035900	-0.007510	-0.051000	7.25e-01	7.90e-01	7.22e-01	9.40e-01	6.12e-01
DNA DOUBLE STRAND BREAK RESPONSE	51	9.35e-01	9.47e-01	0.0716	-2.95e-02	0.035400	-0.026200	0.036500	0.031200	7.15e-01	6.62e-01	7.46e-01	6.52e-01	7.00e-01
INTERFERON SIGNALING	158	5.40e-01	6.22e-01	0.0639	-3.78e-02	-0.009930	-0.046500	-0.004000	0.019400	4.13e-01	8.30e-01	3.14e-01	9.31e-01	6.75e-01

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Detailed Gene set reports

EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION

metric	value
setSize	87
pMANOVA	2.07e-55
p.adjustMANOVA	1.2e-52
s.dist	1.13
s.hyp	0.759
s.amy	0.507
s.hip	-0.568
s.pag	-0.342
s.ni	-0.00585
p.hyp	1.57e-34
p.amy	3.07e-16
p.hip	5.06e-20
p.pag	3.56e-08
p.ni	0.925

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	hip
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Rpl27a	6828	-7291
Rps24	6709	-7080
Rpl35a	6018	-7800
Rps3a1	6918	-6743
Rpl30	5836	-7767
Rplp0	5928	-7544
Rps6	6942	-6281
Rps3	7020	-6127
Rps27a	7082	-6010
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112
Rpl9	6698	-6268
Eef1b2	6449	-6303
Rpl5	5400	-7519
Rps23	6624	-6055
Rps4x	6043	-6599
Rps14	6674	-5674

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Eef1a1	5842	6785	-5330	5852	3484
Eef1a2	-4543	6508	-920	6159	483
Eef1b2	6449	5199	-6303	899	-3563
Eef1d	6613	3278	-1430	-1603	2649
Eef1g	5281	7190	-7135	-2019	-2270
Eef2	4314	5021	-692	5851	6537
Fau	6947	5500	-3002	-4268	2265
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Uba52	6848	4468	-3633	-6717	4906

---

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SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

metric	value
setSize	106
pMANOVA	1.43e-53
p.adjustMANOVA	5.54e-51
s.dist	1.02
s.hyp	0.679
s.amy	0.482
s.hip	-0.536
s.pag	-0.252
s.ni	-0.0297
p.hyp	1.16e-33
p.amy	9.37e-18
p.hip	1.38e-21
p.pag	7.46e-06
p.ni	0.598

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	hip
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Rpl27a	6828	-7291
Ssr3	7259	-6806
Rps24	6709	-7080
Rpl35a	6018	-7800
Sec61g	7494	-6252
Rps3a1	6918	-6743
Rpl30	5836	-7767
Rplp0	5928	-7544
Spcs1	7109	-6134
Rps6	6942	-6281
Rps3	7020	-6127
Rps27a	7082	-6010
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112
Rpl9	6698	-6268
Rpl5	5400	-7519
Rps23	6624	-6055

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ddost	2689	5852	178	-222	6350
Fau	6947	5500	-3002	-4268	2265
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rpn1	3184	2471	-3848	5560	206
Rpn2	5172	3113	-226	1701	5263
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Sec11a	2811	777	-5918	4142	3313
Sec11c	5062	6540	-4788	-1445	-4514
Sec61a1	471	-5147	6812	-1055	6420
Sec61a2	-5128	-5804	1625	2248	2525
Sec61b	7050	1998	-2692	-267	3842
Sec61g	7494	3078	-6252	1216	-3194
Spcs1	7109	7676	-6134	-1457	-3637
Spcs2	4596	5236	-7758	-940	-1235
Spcs3	-951	5788	-7226	8019	-4668
Srp14	2491	3654	-6225	-2175	-1930
Srp19	5501	3923	-7095	-2046	-5228
Srp54a	2371	6778	-7362	-583	-3685
Srp68	146	-924	5594	8778	5107
Srp72	-1720	6982	-2498	1967	18
Srp9	3903	5403	-5598	1841	-5695
Srpr	57	6314	2482	7734	-275
Srprb	-3533	5223	123	4088	5975
Ssr1	-1009	4811	-6664	3822	-2278
Ssr2	4505	3866	-2249	4459	-1372
Ssr3	7259	7301	-6806	7907	-4381
Ssr4	6056	-77	-2472	-2166	869
Tram1	6286	2414	-2960	6419	-2139
Uba52	6848	4468	-3633	-6717	4906

---

---

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

metric	value
setSize	94
pMANOVA	2.5e-48
p.adjustMANOVA	5.79e-46
s.dist	1.02
s.hyp	0.658
s.amy	0.459
s.hip	-0.531
s.pag	-0.341
s.ni	-0.0378
p.hyp	2.44e-28
p.amy	1.37e-14
p.hip	5.95e-19
p.pag	1.15e-08
p.ni	0.527

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	hip
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Rpl27a	6828	-7291
Rps24	6709	-7080
Rpl35a	6018	-7800
Rps3a1	6918	-6743
Rpl30	5836	-7767
Rplp0	5928	-7544
Rps6	6942	-6281
Rps3	7020	-6127
Rps27a	7082	-6010
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112
Rpl9	6698	-6268
Rpl5	5400	-7519
Rps23	6624	-6055
Rps4x	6043	-6599
Rps14	6674	-5674
Rps13	6658	-5585

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Asns	-5966	7218	-5879	7416	-5780
Atf2	-5853	1618	-5009	8379	-4107
Atf3	1404	-1068	-969	-5190	421
Atf4	-500	-1986	-322	-2854	-5481
Cebpb	-2663	4311	6345	545	51
Cebpg	-921	614	-7267	647	-4603
Ddit3	3799	4068	191	-6364	6969
Eif2ak4	-6881	-7902	7761	-429	5235
Eif2s1	-2005	7092	-7557	8513	-7288
Eif2s2	3576	7100	-7798	-5071	-5730
Eif2s3x	3605	7037	-6156	5582	-3408
Fau	6947	5500	-3002	-4268	2265
Gcn1	1819	-7286	7950	-4597	8245
Impact	2197	5313	-5800	-2553	2159
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Uba52	6848	4468	-3633	-6717	4906

---

---

COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS

metric	value
setSize	56
pMANOVA	6.34e-25
p.adjustMANOVA	4.32e-23
s.dist	1.02
s.hyp	0.524
s.amy	0.529
s.hip	-0.49
s.pag	-0.322
s.ni	-0.364
p.hyp	1.15e-11
p.amy	7.61e-12
p.hip	2.26e-10
p.pag	3.01e-05
p.ni	2.46e-06

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	hyp
mt-Nd3	7408	7338
mt-Nd6	7404	6945
mt-Nd5	7228	6493
mt-Nd4	7500	6182
mt-Nd2	7156	6172
Timmdc1	7077	6227
Ndufaf1	6861	6360
mt-Nd1	7302	5713
Ndufc1	7588	5478
Ndufb9	6480	6090
Ndufb11	6214	6181
Ndufs3	5749	6665
Ndufaf5	5439	6835
Ndufaf6	6329	5592
Ndufb4	6291	5445
Ndufb5	7653	4388
Ndufb8	5933	5591
Ndufa5	6832	4783
Ndufa13	5598	4996
Ndufab1	5377	5138

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acad9	-223	1893	1304	8381	-2269
Ecsit	5804	2233	5022	-1686	-733
mt-Nd1	5713	7302	-7260	-2321	-4387
mt-Nd2	6172	7156	-7178	-1628	-4326
mt-Nd3	7338	7408	-7692	-6838	4152
mt-Nd4	6182	7500	-6841	-1057	-3593
mt-Nd5	6493	7228	-6218	323	-1728
mt-Nd6	6945	7404	-6545	-3133	-5124
Ndufa1	6748	2683	-2157	-6312	-902
Ndufa10	-2897	7196	-7177	-8	-6008
Ndufa11	4792	-871	692	-2900	-4202
Ndufa12	3413	7278	-5426	-6561	747
Ndufa13	4996	5598	-100	-5974	3052
Ndufa2	7371	-1281	108	-3657	175
Ndufa3	5608	-178	3145	-6520	2194
Ndufa5	4783	6832	-5305	-6066	-2584
Ndufa6	5333	4559	-3641	-3899	-670
Ndufa7	5517	4328	-848	-4994	618
Ndufa8	3073	1617	-5818	-3234	-821
Ndufa9	822	-1091	-5788	788	-3697
Ndufab1	5138	5377	-1496	-5020	-5347
Ndufaf1	6360	6861	-7005	5350	-6793
Ndufaf2	1250	5934	-7515	-5946	-5312
Ndufaf3	4091	-1081	-921	-2258	1465
Ndufaf4	-1872	7584	-7296	5310	-7177
Ndufaf5	6835	5439	-6668	3096	-6429
Ndufaf6	5592	6329	-4057	6158	-5061
Ndufaf7	6166	-1131	-2436	3536	3759
Ndufb1	6050	3264	-1698	-1495	263
Ndufb10	6236	295	87	-1804	-4747
Ndufb11	6181	6214	-4333	-1648	-4319
Ndufb2	7124	1176	-4656	-3516	-3368
Ndufb3	1908	2378	-5583	-2622	-3149
Ndufb4	5445	6291	-7104	-1955	-1676
Ndufb5	4388	7653	-6548	-596	-5664
Ndufb6	4456	3992	-6276	-853	-4951
Ndufb7	4615	1304	-627	-4767	477
Ndufb8	5591	5933	-4212	863	-3294
Ndufb9	6090	6480	-5430	-3373	-2917
Ndufc1	5478	7588	-6005	-6115	-2867
Ndufc2	5494	4599	-7660	2155	-5168
Ndufs1	-3681	6122	-4475	7932	-5117
Ndufs2	3517	7230	-5627	404	-291
Ndufs3	6665	5749	-3259	-3885	-4643
Ndufs4	3314	7231	-7266	-2564	-5435
Ndufs5	5009	4501	-4850	-3720	-3995
Ndufs6	5790	3657	-4612	-5998	876
Ndufs7	3851	2005	2704	-5631	491
Ndufs8	2820	330	-3399	276	-5754
Ndufv1	6127	3311	-2255	-132	-1731
Ndufv2	2239	7606	-7699	-248	-6975
Ndufv3	2871	189	1198	-6385	479
Nubpl	3659	22	-5925	-2804	-3792
Timmdc1	6227	7077	-1523	4744	115
Tmem126b	-1107	3082	-4188	1889	-2208
Tmem186	-6616	-6830	5069	-23	6134

---

---

EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION

metric	value
setSize	114
pMANOVA	1.05e-51
p.adjustMANOVA	3.04e-49
s.dist	0.987
s.hyp	0.632
s.amy	0.466
s.hip	-0.544
s.pag	-0.232
s.ni	-0.0824
p.hyp	1.64e-31
p.amy	8.36e-18
p.hip	1.03e-23
p.pag	1.83e-05
p.ni	0.129

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	hip
Eif3j2	7062	-7681
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Rpl27a	6828	-7291
Rps24	6709	-7080
Rpl35a	6018	-7800
Rps3a1	6918	-6743
Rpl30	5836	-7767
Rplp0	5928	-7544
Rps6	6942	-6281
Rps3	7020	-6127
Rps27a	7082	-6010
Eif3m	5667	-7483
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112
Rpl9	6698	-6268
Eif3e	5337	-7677
Rpl5	5400	-7519
Rps23	6624	-6055

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Eif1ax	-4860	3567	-6220	8683	-7135
Eif2b1	-5294	-2032	2331	5384	-4104
Eif2b2	1075	4302	6342	2202	7044
Eif2b3	418	-1265	-6348	-1028	-5689
Eif2b4	5390	2863	1933	-4310	-3771
Eif2b5	6017	3167	-2373	2012	-172
Eif2s1	-2005	7092	-7557	8513	-7288
Eif2s2	3576	7100	-7798	-5071	-5730
Eif2s3x	3605	7037	-6156	5582	-3408
Eif3a	-5466	-4407	-5548	-5485	7636
Eif3b	6719	1649	2792	-781	5677
Eif3c	379	2605	-2495	4508	2929
Eif3d	5187	133	-2159	-111	-1035
Eif3e	5337	6632	-7677	5703	-6209
Eif3f	7578	5504	-1607	232	1095
Eif3g	1911	4008	-4892	-1947	-1790
Eif3h	3909	5138	-6624	6093	-5024
Eif3i	5031	2168	260	584	-3998
Eif3j1	447	327	-3803	1564	-3314
Eif3j2	7062	7042	-7681	1110	-6231
Eif3k	4696	-1060	-2241	-2252	122
Eif3l	6167	3558	2184	2519	-2103
Eif3m	5667	6558	-7483	6973	-6901
Eif4a1	7214	2119	-3862	8473	-2901
Eif4a2	-1909	5569	-7748	8454	-7228
Eif4b	-2519	4029	-5314	7202	3034
Eif4e	3462	6423	-7632	5587	-5428
Eif4ebp1	4194	3037	-3086	6171	2112
Eif4g1	-2094	-6038	3643	39	6315
Eif4h	-20	-1019	1451	1662	6195
Eif5	-3507	4697	-7688	-4322	-7378
Eif5b	922	5213	-7771	-6788	3983
Fau	6947	5500	-3002	-4268	2265
Pabpc1	5166	6209	-6820	-150	1038
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Uba52	6848	4468	-3633	-6717	4906

---

---

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

metric	value
setSize	18
pMANOVA	7.27e-07
p.adjustMANOVA	8.52e-06
s.dist	0.959
s.hyp	0.545
s.amy	0.476
s.hip	-0.419
s.pag	-0.266
s.ni	-0.388
p.hyp	6.3e-05
p.amy	0.000473
p.hip	0.00209
p.pag	0.0506
p.ni	0.00437

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	amy
mt-Atp8	7481	6134
mt-Atp6	5940	6271
Atp5h	5831	5803
Atp5a1	3262	7568
Atp5c1	3292	7307
Atp5g3	5588	4002
Atp5b	2582	7635
Atp5j	3596	3600
Atp5l	6035	1630
Atp5e	6877	1262
Atp5d	4951	1682
Atp5pb	768	6940
Dmac2l	1831	2674
Atp5j2	3633	1314
Atp5g1	3142	1013
Atp5k	6671	340
Atp5o	89	3793

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Atp5a1	3262	7568	-5776	6435	-3166
Atp5b	2582	7635	-6207	5299	-4926
Atp5c1	3292	7307	-7106	6710	-7264
Atp5d	4951	1682	1456	-4844	-1506
Atp5e	6877	1262	-3048	-6028	971
Atp5g1	3142	1013	4292	1069	362
Atp5g2	7812	-2852	6008	-4688	732
Atp5g3	5588	4002	-5344	-1122	-3371
Atp5h	5831	5803	-6891	-3998	-5000
Atp5j	3596	3600	-5770	-2772	-1275
Atp5j2	3633	1314	-3475	-3389	-2122
Atp5k	6671	340	5011	-6474	2071
Atp5l	6035	1630	-5466	365	-5546
Atp5o	89	3793	-4474	-1017	-5635
Atp5pb	768	6940	-7332	3309	-7064
Dmac2l	1831	2674	-6907	-2690	-7271
mt-Atp6	5940	6271	-6901	-2603	-4261
mt-Atp8	7481	6134	-19	-4240	7577

---

---

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

metric	value
setSize	59
pMANOVA	3.43e-22
p.adjustMANOVA	1.99e-20
s.dist	0.947
s.hyp	0.588
s.amy	0.472
s.hip	-0.548
s.pag	-0.101
s.ni	-0.13
p.hyp	5.23e-15
p.amy	3.64e-10
p.hip	3.37e-13
p.pag	0.179
p.ni	0.0838

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	hip
Eif3j2	7062	-7681
Rps24	6709	-7080
Rps3a1	6918	-6743
Rps6	6942	-6281
Rps3	7020	-6127
Rps27a	7082	-6010
Eif3m	5667	-7483
Rps8	6897	-6092
Eif3e	5337	-7677
Rps23	6624	-6055
Rps4x	6043	-6599
Rps14	6674	-5674
Rps13	6658	-5585
Rps27l	6486	-5515
Pabpc1	5166	-6820
Rps20	7420	-4681
Rps9	7030	-4933
Rps18	4186	-7830
Rps19	7297	-4363
Rps16	6662	-4772

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Eif1ax	-4860	3567	-6220	8683	-7135
Eif2s1	-2005	7092	-7557	8513	-7288
Eif2s2	3576	7100	-7798	-5071	-5730
Eif2s3x	3605	7037	-6156	5582	-3408
Eif3a	-5466	-4407	-5548	-5485	7636
Eif3b	6719	1649	2792	-781	5677
Eif3c	379	2605	-2495	4508	2929
Eif3d	5187	133	-2159	-111	-1035
Eif3e	5337	6632	-7677	5703	-6209
Eif3f	7578	5504	-1607	232	1095
Eif3g	1911	4008	-4892	-1947	-1790
Eif3h	3909	5138	-6624	6093	-5024
Eif3i	5031	2168	260	584	-3998
Eif3j1	447	327	-3803	1564	-3314
Eif3j2	7062	7042	-7681	1110	-6231
Eif3k	4696	-1060	-2241	-2252	122
Eif3l	6167	3558	2184	2519	-2103
Eif3m	5667	6558	-7483	6973	-6901
Eif4a1	7214	2119	-3862	8473	-2901
Eif4a2	-1909	5569	-7748	8454	-7228
Eif4b	-2519	4029	-5314	7202	3034
Eif4e	3462	6423	-7632	5587	-5428
Eif4ebp1	4194	3037	-3086	6171	2112
Eif4g1	-2094	-6038	3643	39	6315
Eif4h	-20	-1019	1451	1662	6195
Fau	6947	5500	-3002	-4268	2265
Pabpc1	5166	6209	-6820	-150	1038
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042

---

---

RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT

metric	value
setSize	102
pMANOVA	2.69e-39
p.adjustMANOVA	3.12e-37
s.dist	0.944
s.hyp	0.463
s.amy	0.505
s.hip	-0.453
s.pag	-0.271
s.ni	-0.378
p.hyp	6.13e-16
p.amy	1.28e-18
p.hip	2.59e-15
p.pag	2.25e-06
p.ni	4.43e-11

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	hyp
mt-Nd3	7408	7338
mt-Nd6	7404	6945
mt-Co1	7586	6249
mt-Nd5	7228	6493
mt-Nd4	7500	6182
mt-Nd2	7156	6172
Timmdc1	7077	6227
Ndufaf1	6861	6360
Surf1	6724	6478
Cox7a2l	7475	5823
Coq10b	7726	5602
Cox6a1	6258	6832
mt-Nd1	7302	5713
Ndufc1	7588	5478
mt-Co2	7209	5704
mt-Cytb	7126	5768
Ndufb9	6480	6090
Ndufb11	6214	6181
Ndufs3	5749	6665
mt-Co3	7001	5441

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acad9	-223	1893	1304	8381	-2269
Coq10a	1573	5133	519	-5436	-3679
Coq10b	5602	7726	-6242	7945	-5654
Cox11	1249	-6666	1030	4410	-817
Cox14	1993	-2144	-2254	-6083	-3804
Cox16	5116	4514	-5737	-650	-6477
Cox18	2728	3993	5552	8672	1514
Cox19	-964	-4173	-1598	-3118	1112
Cox20	4825	5091	-7142	-5875	-922
Cox4i1	5753	396	-3643	-2518	-1901
Cox5a	4853	6817	-3957	-1299	-5294
Cox5b	5594	5057	476	-6694	1155
Cox6a1	6832	6258	-938	-4507	-2166
Cox6b1	5129	1661	-1189	-4988	-3968
Cox6c	4664	4699	-5263	-3484	-905
Cox7a2l	5823	7475	-6863	-2785	-2170
Cox7b	2532	4317	-6490	-4314	-5047
Cox7c	4841	5582	-3906	-4573	-1845
Cox8a	5258	4350	626	-4321	2681
Cyc1	5209	2215	696	4721	-4027
Cycs	1051	7060	-7801	-4517	-7336
Ecsit	5804	2233	5022	-1686	-733
Etfa	3336	2980	-6849	5562	-5753
Etfb	5301	1904	-4962	-4889	846
Etfdh	-4235	1052	-4450	7841	-4442
Lrpprc	-5904	-6513	-1170	5620	-2061
mt-Co1	6249	7586	-7594	1523	-2152
mt-Co2	5704	7209	-6779	710	-7001
mt-Co3	5441	7001	-6527	-442	-4784
mt-Cytb	5768	7126	-6685	-491	-3196
mt-Nd1	5713	7302	-7260	-2321	-4387
mt-Nd2	6172	7156	-7178	-1628	-4326
mt-Nd3	7338	7408	-7692	-6838	4152
mt-Nd4	6182	7500	-6841	-1057	-3593
mt-Nd5	6493	7228	-6218	323	-1728
mt-Nd6	6945	7404	-6545	-3133	-5124
Ndufa1	6748	2683	-2157	-6312	-902
Ndufa10	-2897	7196	-7177	-8	-6008
Ndufa11	4792	-871	692	-2900	-4202
Ndufa12	3413	7278	-5426	-6561	747
Ndufa13	4996	5598	-100	-5974	3052
Ndufa2	7371	-1281	108	-3657	175
Ndufa3	5608	-178	3145	-6520	2194
Ndufa4	4005	6649	-6249	-3410	-3888
Ndufa5	4783	6832	-5305	-6066	-2584
Ndufa6	5333	4559	-3641	-3899	-670
Ndufa7	5517	4328	-848	-4994	618
Ndufa8	3073	1617	-5818	-3234	-821
Ndufa9	822	-1091	-5788	788	-3697
Ndufab1	5138	5377	-1496	-5020	-5347
Ndufaf1	6360	6861	-7005	5350	-6793
Ndufaf2	1250	5934	-7515	-5946	-5312
Ndufaf3	4091	-1081	-921	-2258	1465
Ndufaf4	-1872	7584	-7296	5310	-7177
Ndufaf5	6835	5439	-6668	3096	-6429
Ndufaf6	5592	6329	-4057	6158	-5061
Ndufaf7	6166	-1131	-2436	3536	3759
Ndufb1	6050	3264	-1698	-1495	263
Ndufb10	6236	295	87	-1804	-4747
Ndufb11	6181	6214	-4333	-1648	-4319
Ndufb2	7124	1176	-4656	-3516	-3368
Ndufb3	1908	2378	-5583	-2622	-3149
Ndufb4	5445	6291	-7104	-1955	-1676
Ndufb5	4388	7653	-6548	-596	-5664
Ndufb6	4456	3992	-6276	-853	-4951
Ndufb7	4615	1304	-627	-4767	477
Ndufb8	5591	5933	-4212	863	-3294
Ndufb9	6090	6480	-5430	-3373	-2917
Ndufc1	5478	7588	-6005	-6115	-2867
Ndufc2	5494	4599	-7660	2155	-5168
Ndufs1	-3681	6122	-4475	7932	-5117
Ndufs2	3517	7230	-5627	404	-291
Ndufs3	6665	5749	-3259	-3885	-4643
Ndufs4	3314	7231	-7266	-2564	-5435
Ndufs5	5009	4501	-4850	-3720	-3995
Ndufs6	5790	3657	-4612	-5998	876
Ndufs7	3851	2005	2704	-5631	491
Ndufs8	2820	330	-3399	276	-5754
Ndufv1	6127	3311	-2255	-132	-1731
Ndufv2	2239	7606	-7699	-248	-6975
Ndufv3	2871	189	1198	-6385	479
Nubpl	3659	22	-5925	-2804	-3792
Sco1	-5382	82	-6610	-5704	-5595
Sco2	-1098	5751	-3041	-4643	-34
Sdha	-4233	4992	-3689	6522	1446
Sdhb	2637	4258	-3153	1534	-5564
Sdhc	4354	7451	-5451	1260	-1331
Sdhd	2384	4786	-4481	4687	-2483
Surf1	6478	6724	-4191	10	-2819
Taco1	3663	4753	5597	5251	-2135
Timmdc1	6227	7077	-1523	4744	115
Tmem126b	-1107	3082	-4188	1889	-2208
Tmem186	-6616	-6830	5069	-23	6134
Trap1	2488	-260	6072	6860	-808
Uqcr10	5292	896	-573	-5544	919
Uqcr11	5354	-835	946	-5647	931
Uqcrb	2765	7015	-5638	-6224	-3361
Uqcrc1	3407	783	1790	127	-1970
Uqcrc2	-1039	5255	-7456	8035	-6300
Uqcrfs1	1309	3713	-825	-1154	-5659
Uqcrh	5525	3146	-4078	-3419	-3583
Uqcrq	5570	4202	-2706	-5676	-40

---

---

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

metric	value
setSize	10
pMANOVA	0.00115
p.adjustMANOVA	0.00564
s.dist	0.941
s.hyp	-0.628
s.amy	-0.311
s.hip	0.445
s.pag	0.0986
s.ni	0.432
p.hyp	0.000583
p.amy	0.0884
p.hip	0.0148
p.pag	0.589
p.ni	0.018

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Top 20 genes

Gene	hyp	hip
Slit1	-6538	7873
Slit3	-6844	6545
Nell2	-7042	4909
Src	-4248	7492
Robo3	-5610	2991
Ntn1	-4586	2851
Robo1	-2991	3972
Robo2	-4861	1733
Dcc	-1685	1941

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Dcc	-1685	-4184	1941	-2671	7267
Nell2	-7042	-3074	4909	7290	3776
Ntn1	-4586	6166	2851	-3796	6434
Robo1	-2991	1523	3972	1416	3473
Robo2	-4861	1007	1733	-138	-1216
Robo3	-5610	-5612	2991	-2415	4154
Slit1	-6538	-6661	7873	3771	6634
Slit2	-4400	-6573	-4050	4734	4864
Slit3	-6844	-2821	6545	3890	-3638
Src	-4248	-5391	7492	5322	7263

---

---

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

metric	value
setSize	11
pMANOVA	0.00326
p.adjustMANOVA	0.0131
s.dist	0.935
s.hyp	0.0865
s.amy	0.647
s.hip	-0.457
s.pag	0.025
s.ni	-0.489
p.hyp	0.619
p.amy	0.000202
p.hip	0.00861
p.pag	0.886
p.ni	0.00501

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	ni
Lgmn	7634	-5732
Hsp90b1	6061	-5638
Tlr3	4442	-7420
Ctss	7660	-4092
Tlr7	6823	-3633
Ctsk	4196	-5897
Ctsb	7553	-2020
Ctsl	5242	-1920
Unc93b1	5518	-1229

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cnpy3	-4481	1570	1691	-1963	2789
Ctsb	1593	7553	-6051	4258	-2020
Ctsk	5099	4196	-1349	-1584	-5897
Ctsl	4603	5242	-7446	4308	-1920
Ctss	2753	7660	-7425	5244	-4092
Hsp90b1	-1003	6061	-7799	-1709	-5638
Lgmn	4688	7634	-5355	6981	-5732
Tlr3	-1485	4442	-7707	4922	-7420
Tlr7	923	6823	-1779	-3083	-3633
Tlr9	-7084	-1352	2153	513	-2526
Unc93b1	2989	5518	2277	-5160	-1229

---

---

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

metric	value
setSize	125
pMANOVA	2.34e-45
p.adjustMANOVA	4.52e-43
s.dist	0.916
s.hyp	0.466
s.amy	0.497
s.hip	-0.433
s.pag	-0.242
s.ni	-0.359
p.hyp	2.14e-19
p.amy	7.63e-22
p.hip	5.78e-17
p.pag	3.15e-06
p.ni	4.37e-12

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hyp
mt-Nd3	7408	7338
mt-Nd6	7404	6945
Slc25a14	6547	7414
mt-Co1	7586	6249
mt-Nd5	7228	6493
mt-Nd4	7500	6182
mt-Atp8	6134	7481
Ucp2	6439	7105
mt-Nd2	7156	6172
Timmdc1	7077	6227
Ndufaf1	6861	6360
Surf1	6724	6478
Cox7a2l	7475	5823
Coq10b	7726	5602
Cox6a1	6258	6832
mt-Nd1	7302	5713
Ndufc1	7588	5478
mt-Co2	7209	5704
mt-Cytb	7126	5768
Ndufb9	6480	6090

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acad9	-223	1893	1304	8381	-2269
Atp5a1	3262	7568	-5776	6435	-3166
Atp5b	2582	7635	-6207	5299	-4926
Atp5c1	3292	7307	-7106	6710	-7264
Atp5d	4951	1682	1456	-4844	-1506
Atp5e	6877	1262	-3048	-6028	971
Atp5g1	3142	1013	4292	1069	362
Atp5g2	7812	-2852	6008	-4688	732
Atp5g3	5588	4002	-5344	-1122	-3371
Atp5h	5831	5803	-6891	-3998	-5000
Atp5j	3596	3600	-5770	-2772	-1275
Atp5j2	3633	1314	-3475	-3389	-2122
Atp5k	6671	340	5011	-6474	2071
Atp5l	6035	1630	-5466	365	-5546
Atp5o	89	3793	-4474	-1017	-5635
Atp5pb	768	6940	-7332	3309	-7064
Coq10a	1573	5133	519	-5436	-3679
Coq10b	5602	7726	-6242	7945	-5654
Cox11	1249	-6666	1030	4410	-817
Cox14	1993	-2144	-2254	-6083	-3804
Cox16	5116	4514	-5737	-650	-6477
Cox18	2728	3993	5552	8672	1514
Cox19	-964	-4173	-1598	-3118	1112
Cox20	4825	5091	-7142	-5875	-922
Cox4i1	5753	396	-3643	-2518	-1901
Cox5a	4853	6817	-3957	-1299	-5294
Cox5b	5594	5057	476	-6694	1155
Cox6a1	6832	6258	-938	-4507	-2166
Cox6b1	5129	1661	-1189	-4988	-3968
Cox6c	4664	4699	-5263	-3484	-905
Cox7a2l	5823	7475	-6863	-2785	-2170
Cox7b	2532	4317	-6490	-4314	-5047
Cox7c	4841	5582	-3906	-4573	-1845
Cox8a	5258	4350	626	-4321	2681
Cyc1	5209	2215	696	4721	-4027
Cycs	1051	7060	-7801	-4517	-7336
Dmac2l	1831	2674	-6907	-2690	-7271
Ecsit	5804	2233	5022	-1686	-733
Etfa	3336	2980	-6849	5562	-5753
Etfb	5301	1904	-4962	-4889	846
Etfdh	-4235	1052	-4450	7841	-4442
Lrpprc	-5904	-6513	-1170	5620	-2061
mt-Atp6	5940	6271	-6901	-2603	-4261
mt-Atp8	7481	6134	-19	-4240	7577
mt-Co1	6249	7586	-7594	1523	-2152
mt-Co2	5704	7209	-6779	710	-7001
mt-Co3	5441	7001	-6527	-442	-4784
mt-Cytb	5768	7126	-6685	-491	-3196
mt-Nd1	5713	7302	-7260	-2321	-4387
mt-Nd2	6172	7156	-7178	-1628	-4326
mt-Nd3	7338	7408	-7692	-6838	4152
mt-Nd4	6182	7500	-6841	-1057	-3593
mt-Nd5	6493	7228	-6218	323	-1728
mt-Nd6	6945	7404	-6545	-3133	-5124
Ndufa1	6748	2683	-2157	-6312	-902
Ndufa10	-2897	7196	-7177	-8	-6008
Ndufa11	4792	-871	692	-2900	-4202
Ndufa12	3413	7278	-5426	-6561	747
Ndufa13	4996	5598	-100	-5974	3052
Ndufa2	7371	-1281	108	-3657	175
Ndufa3	5608	-178	3145	-6520	2194
Ndufa4	4005	6649	-6249	-3410	-3888
Ndufa5	4783	6832	-5305	-6066	-2584
Ndufa6	5333	4559	-3641	-3899	-670
Ndufa7	5517	4328	-848	-4994	618
Ndufa8	3073	1617	-5818	-3234	-821
Ndufa9	822	-1091	-5788	788	-3697
Ndufab1	5138	5377	-1496	-5020	-5347
Ndufaf1	6360	6861	-7005	5350	-6793
Ndufaf2	1250	5934	-7515	-5946	-5312
Ndufaf3	4091	-1081	-921	-2258	1465
Ndufaf4	-1872	7584	-7296	5310	-7177
Ndufaf5	6835	5439	-6668	3096	-6429
Ndufaf6	5592	6329	-4057	6158	-5061
Ndufaf7	6166	-1131	-2436	3536	3759
Ndufb1	6050	3264	-1698	-1495	263
Ndufb10	6236	295	87	-1804	-4747
Ndufb11	6181	6214	-4333	-1648	-4319
Ndufb2	7124	1176	-4656	-3516	-3368
Ndufb3	1908	2378	-5583	-2622	-3149
Ndufb4	5445	6291	-7104	-1955	-1676
Ndufb5	4388	7653	-6548	-596	-5664
Ndufb6	4456	3992	-6276	-853	-4951
Ndufb7	4615	1304	-627	-4767	477
Ndufb8	5591	5933	-4212	863	-3294
Ndufb9	6090	6480	-5430	-3373	-2917
Ndufc1	5478	7588	-6005	-6115	-2867
Ndufc2	5494	4599	-7660	2155	-5168
Ndufs1	-3681	6122	-4475	7932	-5117
Ndufs2	3517	7230	-5627	404	-291
Ndufs3	6665	5749	-3259	-3885	-4643
Ndufs4	3314	7231	-7266	-2564	-5435
Ndufs5	5009	4501	-4850	-3720	-3995
Ndufs6	5790	3657	-4612	-5998	876
Ndufs7	3851	2005	2704	-5631	491
Ndufs8	2820	330	-3399	276	-5754
Ndufv1	6127	3311	-2255	-132	-1731
Ndufv2	2239	7606	-7699	-248	-6975
Ndufv3	2871	189	1198	-6385	479
Nubpl	3659	22	-5925	-2804	-3792
Pm20d1	6710	4549	-1801	8437	2254
Sco1	-5382	82	-6610	-5704	-5595
Sco2	-1098	5751	-3041	-4643	-34
Sdha	-4233	4992	-3689	6522	1446
Sdhb	2637	4258	-3153	1534	-5564
Sdhc	4354	7451	-5451	1260	-1331
Sdhd	2384	4786	-4481	4687	-2483
Slc25a14	7414	6547	-6519	1919	917
Slc25a27	-6853	-6157	6733	2556	1526
Surf1	6478	6724	-4191	10	-2819
Taco1	3663	4753	5597	5251	-2135
Timmdc1	6227	7077	-1523	4744	115
Tmem126b	-1107	3082	-4188	1889	-2208
Tmem186	-6616	-6830	5069	-23	6134
Trap1	2488	-260	6072	6860	-808
Ucp2	7105	6439	6892	4530	8024
Ucp3	-5310	3826	-7173	5653	-4313
Uqcr10	5292	896	-573	-5544	919
Uqcr11	5354	-835	946	-5647	931
Uqcrb	2765	7015	-5638	-6224	-3361
Uqcrc1	3407	783	1790	127	-1970
Uqcrc2	-1039	5255	-7456	8035	-6300
Uqcrfs1	1309	3713	-825	-1154	-5659
Uqcrh	5525	3146	-4078	-3419	-3583
Uqcrq	5570	4202	-2706	-5676	-40

---

---

ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM

metric	value
setSize	10
pMANOVA	0.00105
p.adjustMANOVA	0.00522
s.dist	0.897
s.hyp	-0.379
s.amy	0.535
s.hip	-0.192
s.pag	0.426
s.ni	-0.395
p.hyp	0.0381
p.amy	0.00338
p.hip	0.294
p.pag	0.0197
p.ni	0.0304

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	pag
Folh1	6401	8825
Asns	7218	7416
Got1	6302	6029
Got2	5728	5606
Aspa	4735	6296
Slc25a12	4323	6890
Slc25a13	6902	2611

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Asns	-5966	7218	-5879	7416	-5780
Aspa	-5355	4735	-7317	6296	-7138
Aspg	-3107	-5335	1568	958	3555
Folh1	-207	6401	-1322	8825	-6351
Got1	-6763	6302	693	6029	-3655
Got2	-5515	5728	-3254	5606	-3095
Naalad2	1438	5087	-4389	-1165	1071
Nat8l	-6344	95	4708	-128	-522
Slc25a12	-4131	4323	1142	6890	1
Slc25a13	6898	6902	-149	2611	-4631

---

---

SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM

metric	value
setSize	107
pMANOVA	3.88e-41
p.adjustMANOVA	5e-39
s.dist	0.895
s.hyp	0.589
s.amy	0.41
s.hip	-0.493
s.pag	-0.206
s.ni	-0.0288
p.hyp	5.52e-26
p.amy	2.36e-13
p.hip	1.28e-18
p.pag	0.000241
p.ni	0.607

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	hip
Ahcy	7875	-7076
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Rpl27a	6828	-7291
Rps24	6709	-7080
Rpl35a	6018	-7800
Rps3a1	6918	-6743
Rpl30	5836	-7767
Rplp0	5928	-7544
Rps6	6942	-6281
Rps3	7020	-6127
Rps27a	7082	-6010
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112
Rpl9	6698	-6268
Eef1e1	5266	-7819
Aimp1	5818	-7059
Rpl5	5400	-7519
Rps23	6624	-6055

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ahcy	7875	7163	-7076	-3142	-1721
Aimp1	5818	4633	-7059	-1374	-4460
Aimp2	7342	252	-423	922	-1134
Cbs	1210	-539	-2401	334	1581
Cth	6699	6684	2243	8870	4290
Dars	-5223	5077	-6955	6211	-6616
Eef1e1	5266	6859	-7819	3035	-5617
Eefsec	685	-1701	1157	6309	343
Eprs	-4003	822	-4649	-527	2284
Fau	6947	5500	-3002	-4268	2265
Gsr	1848	5038	-2463	6734	779
Hnmt	-2747	7393	-7568	6827	-7061
Iars	-7223	-4949	5106	7856	1950
Kars	951	7674	-3116	2961	-4641
Lars	-4310	-5636	-1119	6071	5761
Mars1	-2913	-6192	6211	7802	3197
Papss1	2219	6584	-2573	8705	1746
Papss2	2764	4913	-4402	8421	2497
Pstk	5620	-5640	-5176	941	-6337
Qars	6732	1265	5833	8728	4238
Rars	-2965	1416	-7154	1906	-4217
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Sars	-7520	102	-6686	1264	-3622
Scly	-2678	-3253	1812	6494	-1129
Secisbp2	-6914	-6413	7777	-4409	7853
Sephs2	4570	3220	-4306	2080	2102
Sepsecs	-6332	-5352	2119	383	60
Txnrd1	-4884	580	3351	2249	4483
Uba52	6848	4468	-3633	-6717	4906

---

---

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

metric	value
setSize	17
pMANOVA	0.000484
p.adjustMANOVA	0.00264
s.dist	0.873
s.hyp	0.0136
s.amy	-0.39
s.hip	0.443
s.pag	-0.213
s.ni	0.607
p.hyp	0.923
p.amy	0.00543
p.hip	0.00155
p.pag	0.129
p.ni	1.47e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	ni	hip
Mov10	7919	7755
Ago2	7977	6942
Src	7263	7492
Ptpn11	8398	5627
Ago3	7043	6597
Pml	6669	6618
Ago1	6706	6558
Tnrc6b	7065	5031
Tnrc6c	4475	7021
Cdk6	4763	5587
Tnrc6a	4174	5276
Ccnd2	6232	2731
Ccnd3	4514	3194

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ago1	-2283	-5561	6558	1398	6706
Ago2	2135	-6028	6942	-1555	7977
Ago3	4655	-3441	6597	147	7043
Ago4	-5572	-3510	-3501	-129	2793
Cbfb	350	6144	-4171	6499	-1279
Ccnd1	-2912	-2594	-4727	-4105	-1294
Ccnd2	-2201	-5879	2731	-5112	6232
Ccnd3	7213	2776	3194	2964	4514
Cdk6	4074	-5669	5587	-1312	4763
Mov10	1199	-7383	7755	-6462	7919
Pml	37	5123	6618	-688	6669
Ptpn11	7412	3411	5627	8794	8398
Runx1	2869	-2441	-2671	-285	6433
Src	-4248	-5391	7492	5322	7263
Tnrc6a	-4484	-7683	5276	-6074	4174
Tnrc6b	2655	-7962	5031	-5379	7065
Tnrc6c	-7432	-7993	7021	-6368	4475

---

---

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

metric	value
setSize	29
pMANOVA	4.43e-06
p.adjustMANOVA	4.43e-05
s.dist	0.851
s.hyp	0.22
s.amy	0.486
s.hip	-0.495
s.pag	0.109
s.ni	-0.428
p.hyp	0.0408
p.amy	5.8e-06
p.hip	3.95e-06
p.pag	0.309
p.ni	6.64e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	amy
Ube2r2	-6876	7729
Ube2l3	-7584	6827
Ube2g1	-6605	7419
Ube2d2a	-7599	5877
Ube2a	-7126	6267
Ube2d1	-7578	5731
Ube2e1	-7552	5183
Ube2e3	-6962	5560
Ube2b	-7643	5030
Rps27a	-6010	6031
Ube2w	-6980	5074
Ube2q2	-6173	5090
Otulin	-3492	5312
Uchl3	-5735	3094
Uba52	-3633	4468
Ube2k	-7279	2035
Uba6	-2637	4463
Usp9x	-1929	4625
Ubb	-1569	4259
Cdc34	-1415	3488

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cdc34	395	3488	-1415	62	-4558
Otulin	3149	5312	-3492	-3456	712
Rps27a	7082	6031	-6010	-1860	-1558
Uba1	-5013	300	2093	6633	2270
Uba52	6848	4468	-3633	-6717	4906
Uba6	3200	4463	-2637	6979	-5886
Ubb	78	4259	-1569	-1900	-1839
Ubc	-6659	-637	164	5564	729
Ube2a	4048	6267	-7126	5660	-7314
Ube2b	4285	5030	-7643	1084	-7410
Ube2d1	1354	5731	-7578	-3639	-6992
Ube2d2a	3939	5877	-7599	1936	-6707
Ube2e1	5912	5183	-7552	1799	-6935
Ube2e3	3580	5560	-6962	3865	-6553
Ube2g1	3326	7419	-6605	7460	-7312
Ube2g2	-1413	-1719	5240	-65	5464
Ube2h	-1044	2487	1637	-175	6616
Ube2k	1049	2035	-7279	-2962	-6436
Ube2l3	2395	6827	-7584	2941	-7075
Ube2q2	-4957	5090	-6173	4501	-5523
Ube2r2	7035	7729	-6876	-4737	-1872
Ube2s	4344	798	-3083	-1515	-3105
Ube2t	-5183	-640	-6646	269	-5602
Ube2w	6617	5074	-6980	6307	-7369
Ube2z	2244	3981	905	3175	2803
Uchl3	6281	3094	-5735	7194	-7217
Usp5	3588	2331	1682	7371	3193
Usp7	-3858	-1621	-377	2487	-1185
Usp9x	544	4625	-1929	4617	-2579

---

---

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

metric	value
setSize	10
pMANOVA	0.0027
p.adjustMANOVA	0.0113
s.dist	0.843
s.hyp	0.641
s.amy	0.0984
s.hip	0.245
s.pag	0.029
s.ni	0.478
p.hyp	0.000448
p.amy	0.59
p.hip	0.179
p.pag	0.874
p.ni	0.00886

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Top 20 genes

Gene	hyp	ni
Tead2	7751	7635
Yap1	7944	6238
Hipk2	5960	8190
Tead1	7094	6639
Ccn2	7565	3047
Runx2	2860	5991
Tead3	1988	7184
Hipk1	1040	8274

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ccn2	7565	1018	-1418	8675	3047
Hipk1	1040	-2949	4893	676	8274
Hipk2	5960	-3216	5717	-5311	8190
Kat2b	3616	7260	-294	6081	-4436
Runx2	2860	-5789	7742	-5637	5991
Tead1	7094	3326	7301	7573	6639
Tead2	7751	5583	-2571	-5296	7635
Tead3	1988	1461	3885	-1942	7184
Wwtr1	5927	6223	-5521	-823	-6096
Yap1	7944	-6081	679	7888	6238

---

---

CRISTAE FORMATION

CRISTAE FORMATION

metric	value
setSize	31
pMANOVA	5e-08
p.adjustMANOVA	7.25e-07
s.dist	0.841
s.hyp	0.387
s.amy	0.423
s.hip	-0.435
s.pag	-0.16
s.ni	-0.406
p.hyp	0.000196
p.amy	4.57e-05
p.hip	2.73e-05
p.pag	0.123
p.ni	9.25e-05

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	amy
Atp5c1	-7106	7307
Atp5pb	-7332	6940
Apoo	-7725	6417
Atp5b	-6207	7635
Atp5a1	-5776	7568
mt-Atp6	-6901	6271
Atp5h	-6891	5803
Immt	-5032	7073
Hspa9	-6953	4262
Apool	-4676	5843
Mtx2	-7276	3173
Chchd3	-3804	6062
Atp5g3	-5344	4002
Atp5j	-5770	3600
Dmac2l	-6907	2674
Atp5o	-4474	3793
Micos13	-2073	5061
Atp5l	-5466	1630
Micos10	-6735	980
Atp5j2	-3475	1314

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Apoo	-1046	6417	-7725	-2025	-7431
Apool	-6774	5843	-4676	5987	-6029
Atp5a1	3262	7568	-5776	6435	-3166
Atp5b	2582	7635	-6207	5299	-4926
Atp5c1	3292	7307	-7106	6710	-7264
Atp5d	4951	1682	1456	-4844	-1506
Atp5e	6877	1262	-3048	-6028	971
Atp5g1	3142	1013	4292	1069	362
Atp5g2	7812	-2852	6008	-4688	732
Atp5g3	5588	4002	-5344	-1122	-3371
Atp5h	5831	5803	-6891	-3998	-5000
Atp5j	3596	3600	-5770	-2772	-1275
Atp5j2	3633	1314	-3475	-3389	-2122
Atp5k	6671	340	5011	-6474	2071
Atp5l	6035	1630	-5466	365	-5546
Atp5o	89	3793	-4474	-1017	-5635
Atp5pb	768	6940	-7332	3309	-7064
Chchd3	4658	6062	-3804	6133	-4867
Chchd6	6134	-13	-2225	-2862	-279
Dmac2l	1831	2674	-6907	-2690	-7271
Dnajc11	-6374	-969	3386	25	2639
Hspa9	-4747	4262	-6953	3404	-2333
Immt	987	7073	-5032	8554	-4731
Micos10	4357	980	-6735	-3727	-3681
Micos13	6749	5061	-2073	-2197	-2606
mt-Atp6	5940	6271	-6901	-2603	-4261
mt-Atp8	7481	6134	-19	-4240	7577
Mtx1	4678	-1658	3317	-2614	256
Mtx2	5286	3173	-7276	1342	-7116
Samm50	3594	-2059	-2672	4136	132
Tmem11	911	515	-3327	-5018	-1933

---

---

CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE

metric	value
setSize	22
pMANOVA	3.86e-05
p.adjustMANOVA	0.000311
s.dist	0.837
s.hyp	0.0475
s.amy	0.488
s.hip	-0.325
s.pag	0.474
s.ni	-0.361
p.hyp	0.7
p.amy	7.53e-05
p.hip	0.00832
p.pag	0.000119
p.ni	0.00339

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Top 20 genes

Gene	amy	pag
Idh3a	7599	8335
Suclg2	6790	8136
Sucla2	6618	7368
Idh2	6011	7609
Fh1	4950	8633
Dld	4393	8197
Aco2	4017	8125
Sdha	4992	6522
Cs	4758	5087
Sdhd	4786	4687
Me2	3298	5870
Ogdh	3616	4380
Sdhc	7451	1260
Mdh2	3522	2092
Sdhb	4258	1534
Nnt	3840	1500
Suclg1	5080	920

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Aco2	-2899	4017	-767	8125	-3592
Cs	-6854	4758	-2380	5087	-633
Dld	-3369	4393	-7580	8197	-7367
Dlst	7102	-334	2489	5887	1979
Fahd1	5601	1492	-5762	-3589	-7106
Fh1	3681	4950	-7203	8633	-4238
Idh2	7942	6011	6239	7609	8327
Idh3a	-5972	7599	-6565	8335	-5870
Idh3b	-309	-2320	-331	7275	-3421
Idh3g	-5879	-2054	4003	4685	-5533
Mdh2	3352	3522	153	2092	-3797
Me2	-4208	3298	-4299	5870	-2041
Me3	-5548	51	856	-876	-6657
Nnt	2533	3840	-302	1500	417
Ogdh	-5192	3616	2213	4380	2599
Sdha	-4233	4992	-3689	6522	1446
Sdhb	2637	4258	-3153	1534	-5564
Sdhc	4354	7451	-5451	1260	-1331
Sdhd	2384	4786	-4481	4687	-2483
Sucla2	1547	6618	-6920	7368	-7297
Suclg1	5822	5080	-4978	920	-5991
Suclg2	7900	6790	-6547	8136	5837

---

---

NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD

metric	value
setSize	109
pMANOVA	1.59e-37
p.adjustMANOVA	1.54e-35
s.dist	0.831
s.hyp	0.529
s.amy	0.364
s.hip	-0.441
s.pag	-0.289
s.ni	-0.00924
p.hyp	1.29e-21
p.amy	5.13e-11
p.hip	1.86e-15
p.pag	1.94e-07
p.ni	0.868

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Top 20 genes

Gene	hyp	hip
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Rpl27a	6828	-7291
Rps24	6709	-7080
Rpl35a	6018	-7800
Rps3a1	6918	-6743
Rpl30	5836	-7767
Rplp0	5928	-7544
Magoh	7231	-6150
Rps6	6942	-6281
Rbm8a	5811	-7451
Rps3	7020	-6127
Rps27a	7082	-6010
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112
Rpl9	6698	-6268
Rpl5	5400	-7519
Rps23	6624	-6055
Rps4x	6043	-6599

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Casc3	-3777	-7687	6714	-2911	5522
Dcp1a	-4784	-3200	4946	-604	-786
Eif4a3	3291	4308	-1393	4990	1088
Eif4g1	-2094	-6038	3643	39	6315
Etf1	-5025	4918	-6801	1360	-5207
Fau	6947	5500	-3002	-4268	2265
Gspt1	-2199	4680	1982	6293	-1788
Gspt2	-4477	-2824	259	4159	-1368
Magoh	7231	-2219	-6150	3231	-6791
Magohb	-6312	4537	-3668	-1775	-6283
Ncbp1	6212	4119	2873	8014	3608
Ncbp2	-4958	-1966	-7185	1839	-5507
Pabpc1	5166	6209	-6820	-150	1038
Pnrc2	4846	6452	-6515	7159	-4882
Ppp2ca	-2556	5756	-6691	4844	-5976
Ppp2r1a	-4110	5538	751	4348	-1436
Ppp2r2a	-4981	7402	-7327	6875	-5282
Rbm8a	5811	7279	-7451	-4580	-2718
Rnps1	-1894	1589	835	-2072	4412
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Smg1	250	-7612	7000	4034	3057
Smg5	-3668	-6114	7921	-649	5251
Smg6	-6220	-7886	4923	-3786	6703
Smg7	-269	-5651	4603	2527	4663
Smg8	-4942	3677	3928	-571	-1840
Smg9	-6355	-4420	5956	-2269	4834
Uba52	6848	4468	-3633	-6717	4906
Upf1	-2578	-7223	7370	-1152	7849
Upf2	-48	-5583	-3729	-6137	1775
Upf3a	-1349	-3139	-2142	-3871	4799
Upf3b	-563	1991	-6125	-6208	2890

---

---

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

metric	value
setSize	15
pMANOVA	1.56e-05
p.adjustMANOVA	0.00014
s.dist	0.82
s.hyp	0.366
s.amy	0.478
s.hip	0.0413
s.pag	0.356
s.ni	0.426
p.hyp	0.0142
p.amy	0.00134
p.hip	0.782
p.pag	0.0169
p.ni	0.00425

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	ni
Hif3a	6238	7690
Fgf2	5676	7601
Sall1	6097	5629
Epas1	3803	8369
Stat3	3692	8040
Sox2	7456	3150
Klf4	5723	3870
Smad4	6707	2032
Foxp1	2263	3375
Pbx1	548	7598
Hhex	6348	312
Smad2	2974	366

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Epas1	7778	3803	5403	6669	8369
Fgf2	7789	5676	4951	7943	7601
Foxp1	766	2263	-6592	-2452	3375
Hhex	-4212	6348	-2643	2720	312
Hif3a	7470	6238	7942	8273	7690
Klf4	6589	5723	-2132	5768	3870
Nr6a1	6436	-5666	7231	3526	3674
Pbx1	5250	548	-5226	-6006	7598
Sall1	3545	6097	6257	8154	5629
Smad2	-2840	2974	-5288	5901	366
Smad4	744	6707	629	415	2032
Sox2	1029	7456	-6631	1628	3150
Stat3	-1620	3692	5988	1203	8040
Tsc22d1	3722	3133	-1813	5126	-2273
Zic3	2428	392	-1700	7834	-1593

---

---

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

metric	value
setSize	20
pMANOVA	0.000276
p.adjustMANOVA	0.00162
s.dist	0.817
s.hyp	0.0615
s.amy	0.529
s.hip	-0.36
s.pag	0.399
s.ni	-0.307
p.hyp	0.634
p.amy	4.19e-05
p.hip	0.00532
p.pag	0.00199
p.ni	0.0174

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	pag
Acsbg1	7268	8731
Acsl3	7253	8490
Hsd17b12	7575	7479
Hacd2	6920	6815
Elovl1	7825	5958
Elovl2	5343	8367
Elovl5	7483	5779
Elovl4	6579	6222
Acsl4	5525	6958
Acsl1	4088	7155
Acsl6	3455	8026
Hacd3	7478	1062
Elovl6	1372	3452

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acsbg1	4888	7268	-20	8731	3253
Acsf3	-278	-5092	-389	3778	468
Acsl1	-7444	4088	1607	7155	3320
Acsl3	-4553	7253	-6511	8490	-6018
Acsl4	-70	5525	-6184	6958	-89
Acsl5	-7675	-902	-7199	3501	492
Acsl6	-3742	3455	-2019	8026	-5545
Elovl1	6177	7825	4114	5958	1577
Elovl2	7709	5343	-5843	8367	-6905
Elovl4	3662	6579	-6224	6222	-7069
Elovl5	957	7483	-7070	5779	-5836
Elovl6	-774	1372	2803	3452	2541
Elovl7	-3779	3472	-7164	-5184	-7233
Hacd1	6456	7133	-5399	-4774	-3708
Hacd2	6559	6920	-1590	6815	-1481
Hacd3	1437	7478	-7340	1062	-5581
Hacd4	1231	-239	-407	6347	-910
Hsd17b12	1898	7575	-7757	7479	-6880
Slc27a3	-1381	-4793	7439	-2144	4413
Tecr	381	4135	95	-3597	2117

---

---

MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION

metric	value
setSize	93
pMANOVA	1.98e-25
p.adjustMANOVA	1.43e-23
s.dist	0.815
s.hyp	0.363
s.amy	0.365
s.hip	-0.418
s.pag	-0.207
s.ni	-0.427
p.hyp	1.46e-09
p.amy	1.17e-09
p.hip	3.29e-12
p.pag	0.000552
p.ni	1.13e-12

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	ni	hip
Ptcd3	-7248	-7026
Mrps30	-6716	-7474
Mrps22	-6545	-7538
Mrpl50	-6396	-7620
Mrpl1	-6756	-7093
Mrps31	-6183	-7583
Mrpl32	-6809	-6618
Mrpl47	-7022	-6362
Mrpl16	-6578	-6606
Mrpl15	-5362	-7346
Mrpl42	-6769	-5767
Mrps2	-6985	-5197
Mrps23	-5142	-6808
Chchd1	-5478	-6374
Mrpl13	-4890	-6882
Mrpl18	-6341	-5271
Mrpl34	-5043	-6329
Mrps36	-4577	-6966
Mrpl48	-4345	-7130
Mrpl35	-5254	-5857

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Aurkaip1	4614	5558	-4160	-2251	-302
Chchd1	6265	4829	-6374	-732	-5478
Dap3	5422	521	3037	5019	4724
Eral1	7643	1984	7056	-1829	3907
Gadd45gip1	2721	-314	-1319	-4768	-2074
Gfm1	-3981	2934	-1188	3422	-4263
Gfm2	1938	-6044	3378	2703	-2849
Mrpl1	-7180	5785	-7093	3986	-6756
Mrpl10	-1130	2987	-4379	-1158	-5372
Mrpl11	5623	3945	-5696	-3026	-4904
Mrpl12	5558	1587	-3993	-1298	-4227
Mrpl13	2856	6530	-6882	172	-4890
Mrpl14	6767	965	-622	-3628	1497
Mrpl15	4459	7744	-7346	3571	-5362
Mrpl16	6606	592	-6606	8092	-6578
Mrpl17	4331	5408	-4807	2562	-2570
Mrpl18	2427	4852	-5271	-355	-6341
Mrpl19	-1352	1193	-6677	-3829	-1801
Mrpl2	4079	3305	691	-1588	996
Mrpl20	4103	-706	-338	-3008	-3121
Mrpl21	3581	2583	-2101	-4468	-4439
Mrpl22	-3188	4925	-2252	3053	-6077
Mrpl23	7765	926	-4397	-4350	-180
Mrpl24	5257	4555	-4501	-3880	-626
Mrpl27	3428	-2046	-2424	-3074	-3272
Mrpl28	5330	4610	-1730	-3889	-2167
Mrpl3	1821	-797	-4432	5610	-6752
Mrpl30	2375	6915	-5619	-771	-4228
Mrpl32	6513	6674	-6618	2593	-6809
Mrpl33	4620	4415	-6854	-4559	-3789
Mrpl34	5231	7084	-6329	319	-5043
Mrpl35	6296	3589	-5857	2459	-5254
Mrpl36	6196	355	-1090	526	-4108
Mrpl37	5532	-1016	5134	6906	-3081
Mrpl38	234	960	2806	-706	3778
Mrpl39	-775	4606	-5903	1227	-4147
Mrpl4	5367	-1136	6689	743	-1215
Mrpl40	654	3611	-5048	-183	-6024
Mrpl41	5152	2196	-2580	-2538	-473
Mrpl42	4377	6564	-5767	-1982	-6769
Mrpl43	5126	3937	-4197	-1599	-3613
Mrpl44	-3002	4167	-3913	-2586	-1922
Mrpl46	5012	2592	-2727	-1258	-4213
Mrpl47	6600	6553	-6362	351	-7022
Mrpl48	4333	7385	-7130	-5143	-4345
Mrpl49	502	1746	-3363	3402	-3181
Mrpl50	961	5197	-7620	2550	-6396
Mrpl51	7706	5529	-3027	-5202	-4235
Mrpl52	6885	3949	-1776	-2920	-897
Mrpl53	5845	-1841	240	-2805	-1609
Mrpl54	4385	6380	-5934	-4566	-2638
Mrpl55	-4626	-978	-565	-5397	-1688
Mrpl57	4424	1934	824	-4638	-1423
Mrpl58	1876	-766	1780	-2469	-724
Mrpl9	7161	-3585	-3016	2971	-1533
Mrps10	215	6505	-5898	-4124	-2965
Mrps11	2035	-159	1668	-561	-1267
Mrps12	587	-103	-673	-3990	-3420
Mrps14	4296	4596	-5437	-71	-5449
Mrps15	5881	6006	-632	-595	-389
Mrps16	4563	1621	-3782	-669	-756
Mrps17	5914	45	-2768	-3134	-498
Mrps18a	738	4320	-3886	-2802	-3970
Mrps18b	1745	901	-4179	-4604	-3322
Mrps18c	6157	3948	-7293	-2161	-3898
Mrps2	-680	6954	-5197	-5971	-6985
Mrps21	4229	1794	-2311	-6161	-2709
Mrps22	1963	6322	-7538	4375	-6545
Mrps23	5781	2986	-6808	-4095	-5142
Mrps24	3534	4279	-2133	-1323	-1553
Mrps25	1238	1177	-6179	-2179	-1114
Mrps26	3479	-1196	-227	-2827	883
Mrps27	4179	-1009	3554	-1849	-3929
Mrps28	416	-534	-3744	2386	-134
Mrps30	5315	5329	-7474	7828	-6716
Mrps31	-6681	7791	-7583	8342	-6183
Mrps33	4155	4824	-5212	-3519	-4045
Mrps34	3689	-2324	1714	-4722	1723
Mrps35	7590	3520	-6129	551	-3984
Mrps36	105	7224	-6966	-949	-4577
Mrps5	-6448	4312	-6132	-2536	1182
Mrps6	7257	3069	-3408	2692	879
Mrps7	4786	3072	-4770	673	-2045
Mrps9	6323	2200	-3785	-1118	-2722
Mrrf	-1483	2373	-1183	5136	-6128
Mtfmt	2569	2833	1542	-5841	596
Mtif2	48	-3945	-4339	4828	-7027
Mtif3	-4103	403	-5729	-1995	-240
Mtrf1l	2220	-622	-4687	5297	5812
Oxa1l	3527	5319	5555	-1537	-2316
Ptcd3	-7512	3653	-7026	6757	-7248
Tsfm	2542	1880	-5037	-5904	-766
Tufm	4156	3964	1136	-2236	539

---

---

BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM

metric	value
setSize	21
pMANOVA	3.84e-05
p.adjustMANOVA	0.000311
s.dist	0.809
s.hyp	0.411
s.amy	0.405
s.hip	-0.279
s.pag	0.443
s.ni	-0.22
p.hyp	0.00112
p.amy	0.00133
p.hip	0.027
p.pag	0.000436
p.ni	0.0807

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	pag	hyp
Ivd	8250	7411
Acad8	6686	7824
Aldh6a1	8764	5718
Bcat2	6295	7893
Acadsb	6363	7432
Dbt	6820	6058
Mccc1	5008	7649
Bckdhb	6256	5888
Echs1	7893	4463
Mccc2	5532	5560
Hibadh	7590	2305
Hsd17b10	3002	4709
Acat1	7789	1457

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acad8	7824	-177	5887	6686	-3401
Acadsb	7432	4847	-5878	6363	-5071
Acat1	1457	1790	-5125	7789	-7013
Aldh6a1	5718	7109	-5432	8764	-6184
Auh	-3150	6793	-5348	-1657	-6473
Bcat1	-5455	7127	781	2233	1925
Bcat2	7893	-7044	6681	6295	7555
Bckdha	5548	3056	-542	-1030	4695
Bckdhb	5888	7754	-4445	6256	-6787
Bckdk	-3415	1541	-1829	-931	-2434
Dbt	6058	5755	-2087	6820	4714
Dld	-3369	4393	-7580	8197	-7367
Echs1	4463	3961	-6304	7893	-3864
Hibadh	2305	7762	-7777	7590	-6546
Hibch	1030	2939	-7415	-57	-4450
Hsd17b10	4709	6110	-7315	3002	-4751
Ivd	7411	4953	7123	8250	6832
Mccc1	7649	-1815	4741	5008	5592
Mccc2	5560	1102	-2431	5532	-2734
Ppm1k	6371	-5639	-5405	-5511	2883
Slc25a44	-1609	2948	5408	6367	6320

---

---

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

metric	value
setSize	12
pMANOVA	0.00196
p.adjustMANOVA	0.00853
s.dist	0.804
s.hyp	0.413
s.amy	0.466
s.hip	-0.0991
s.pag	0.469
s.ni	0.169
p.hyp	0.0133
p.amy	0.00521
p.hip	0.552
p.pag	0.00487
p.ni	0.311

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	pag	amy
Hsd17b4	8480	7112
Elovl1	5958	7825
Elovl2	8367	5343
Elovl5	5779	7483
Acox1	8281	5063
Fads2	8081	4525
Scp2	4018	7349
Acsl1	7155	4088
Fads1	6817	4083

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Abcd1	2138	-2337	7120	-3781	4569
Acaa1a	7036	-6404	2838	-454	2086
Acot8	6152	-1000	2981	-2565	5119
Acox1	-1877	5063	91	8281	6013
Acsl1	-7444	4088	1607	7155	3320
Elovl1	6177	7825	4114	5958	1577
Elovl2	7709	5343	-5843	8367	-6905
Elovl5	957	7483	-7070	5779	-5836
Fads1	4541	4083	-3683	6817	5543
Fads2	6800	4525	-681	8081	7421
Hsd17b4	1747	7112	-3024	8480	4140
Scp2	6440	7349	-6693	4018	-5247

---

---

CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY

metric	value
setSize	10
pMANOVA	0.0357
p.adjustMANOVA	0.0859
s.dist	0.783
s.hyp	0.144
s.amy	0.4
s.hip	-0.498
s.pag	0.346
s.ni	-0.253
p.hyp	0.429
p.amy	0.0283
p.hip	0.00637
p.pag	0.0579
p.ni	0.167

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	amy
Cdc42	-7712	6102
Rac1	-5358	7426
Pak2	-4609	7648
Pak1	-7593	4283
Pak3	-6357	4093
Cd86	-4620	4094
Grb2	-2556	1098

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cd86	1178	4094	-4620	339	-273
Cdc42	3471	6102	-7712	4032	-7012
Fyn	-2945	222	913	8170	924
Grb2	-1666	1098	-2556	-1689	331
Lck	3320	-4006	-1650	1717	890
Pak1	-6016	4283	-7593	6992	-6413
Pak2	1092	7648	-4609	8226	-21
Pak3	2366	4093	-6357	-5031	1707
Rac1	4037	7426	-5358	8115	-4863
Vav1	7572	-188	1046	6164	-491

---

---

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

metric	value
setSize	46
pMANOVA	8.06e-10
p.adjustMANOVA	1.91e-08
s.dist	0.783
s.hyp	0.42
s.amy	0.38
s.hip	-0.458
s.pag	-0.0182
s.ni	-0.287
p.hyp	8.52e-07
p.amy	8.29e-06
p.hip	7.47e-08
p.pag	0.831
p.ni	0.000766

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	hyp
Psma3	-7489	6690
Psme2	-6094	7552
Psmd14	-7045	6264
Psmd10	-6730	6335
Psmb7	-6836	5789
Psmb1	-7081	5425
Psma1	-6202	5607
Psmd7	-6186	5456
Psmd8	-5941	5672
Psmd6	-6924	4799
Psma6	-7561	4242
Psma2	-6869	4297
Psmc5	-4266	6184
Psma5	-6617	3323
Psmb4	-3788	5774
Psma7	-4973	4349
Psmb8	-6298	3419
Sem1	-3004	6677
Psmc3	-2887	5783
Psmb10	-2384	5365

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Fcgr1	1801	4048	-3550	3471	13
Mrc1	-3660	5314	-5461	-686	-878
Mrc2	5533	1301	409	5236	7901
Psma1	5607	5571	-6202	4742	-6763
Psma2	4297	5066	-6869	4103	-6534
Psma3	6690	6047	-7489	-1552	-2237
Psma4	1746	4585	-6654	-1796	-5553
Psma5	3323	-1473	-6617	3568	-4793
Psma6	4242	5431	-7561	5365	-5733
Psma7	4349	2254	-4973	-1616	-2289
Psmb1	5425	6833	-7081	1876	-5399
Psmb10	5365	-1177	-2384	-3876	1032
Psmb2	6874	4672	1134	-1064	290
Psmb3	5156	749	-798	-1635	-2799
Psmb4	5774	5078	-3788	-2700	2441
Psmb5	5739	552	3826	-5060	1805
Psmb6	5243	-395	-1575	-982	-213
Psmb7	5789	3930	-6836	521	-5745
Psmb8	3419	2737	-6298	-2899	3478
Psmb9	840	-4742	-2793	-4571	167
Psmc1	1283	7563	-7755	-3571	-2837
Psmc2	399	6671	-6314	1438	-4043
Psmc3	5783	1161	-2887	2024	-4416
Psmc4	5458	8	2121	456	273
Psmc5	6184	5195	-4266	1972	-5212
Psmc6	-4950	6648	-7434	8559	-7419
Psmd1	-1911	7525	-6549	-2341	-251
Psmd10	6335	1117	-6730	3842	-5683
Psmd11	770	979	600	-3451	-1053
Psmd12	-7349	6212	-7689	6526	-7219
Psmd13	6487	-1504	-1320	4366	-2360
Psmd14	6264	5293	-7045	6717	-6868
Psmd2	-866	-163	-93	7544	1305
Psmd3	6427	-50	6650	4129	3084
Psmd4	3270	646	1379	-3445	2190
Psmd5	-1202	4465	-2978	7366	-2873
Psmd6	4799	5502	-6924	6782	-5318
Psmd7	5456	5674	-6186	-2000	2853
Psmd8	5672	7148	-5941	527	-6056
Psmd9	6231	3555	169	-2328	6272
Psme1	4251	89	-2892	-1727	7025
Psme2	7552	1605	-6094	-5627	-1591
Psme3	3041	4955	-3094	1531	-1448
Psme4	-2266	-7768	3279	1953	-3258
Psmf1	-357	3225	355	-1462	-3411
Sem1	6677	1611	-3004	-2721	-2140

---

---

ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY

metric	value
setSize	10
pMANOVA	0.0222
p.adjustMANOVA	0.059
s.dist	0.782
s.hyp	-0.23
s.amy	-0.143
s.hip	0.509
s.pag	0.216
s.ni	0.481
p.hyp	0.207
p.amy	0.433
p.hip	0.00527
p.pag	0.238
p.ni	0.00841

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Adcy6	7795	8016
Adcy4	7027	7161
Adcy5	5623	7248
Adcy3	5782	4301
Adcy7	5312	4016
Adcy9	5533	3542

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Adcy1	-3124	-7209	7337	3071	-344
Adcy2	-465	1491	-1257	2824	6941
Adcy3	-547	2037	5782	5240	4301
Adcy4	6997	3864	7027	-1063	7161
Adcy5	-1847	3621	5623	4740	7248
Adcy6	1887	-7721	7795	-2235	8016
Adcy7	-6226	-1965	5312	1596	4016
Adcy8	-7778	-6862	-3588	6961	3448
Adcy9	-4541	-1195	5533	1773	3542
Gnal	-1643	1625	1785	3766	-1406

---

---

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

metric	value
setSize	19
pMANOVA	0.000123
p.adjustMANOVA	0.000837
s.dist	0.78
s.hyp	0.335
s.amy	0.536
s.hip	-0.45
s.pag	0.0792
s.ni	-0.0171
p.hyp	0.0115
p.amy	5.23e-05
p.hip	0.000683
p.pag	0.55
p.ni	0.897

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hip
Gng12	7515	-6690
P2ry12	7129	-6942
Gng11	6359	-7726
Gng10	6845	-6717
Gnai3	6755	-6716
Gnai1	4840	-5834
Gng5	6768	-4033
Gng3	4040	-3698
Gngt2	2703	-4937
Gnb4	2513	-4981
Gng2	1484	-3776
Gng4	1922	-2274
Gnb5	6422	-416
Gnb1	562	-4711
Gng13	876	-2000

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Gnai1	-925	4840	-5834	7661	-4590
Gnai2	4203	3914	433	6521	7741
Gnai3	-1547	6755	-6716	6427	-4089
Gnb1	2424	562	-4711	4583	2808
Gnb2	2994	1299	1979	-3129	6752
Gnb4	5820	2513	-4981	-4209	1087
Gnb5	-4148	6422	-416	6663	-54
Gng10	7096	6845	-6717	-307	-2431
Gng11	4240	6359	-7726	-4008	-6172
Gng12	7152	7515	-6690	8503	-1242
Gng13	5363	876	-2000	-6509	1166
Gng2	-5582	1484	-3776	7437	114
Gng3	3295	4040	-3698	-2839	914
Gng4	-97	1922	-2274	-2436	7958
Gng5	7547	6768	-4033	-917	-723
Gng7	2144	4904	2348	7620	-625
Gng8	5084	1977	836	3403	1193
Gngt2	5943	2703	-4937	-6945	2790
P2ry12	1188	7129	-6942	2626	-6072

---

---

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

metric	value
setSize	172
pMANOVA	4.18e-39
p.adjustMANOVA	4.41e-37
s.dist	0.779
s.hyp	0.336
s.amy	0.461
s.hip	-0.404
s.pag	-0.0921
s.ni	-0.331
p.hyp	3.29e-14
p.amy	1.69e-25
p.hip	6.97e-20
p.pag	0.0374
p.ni	6.75e-14

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hip
Ndufv2	7606	-7699
mt-Co1	7586	-7594
mt-Nd3	7408	-7692
Ndufaf4	7584	-7296
Cycs	7060	-7801
mt-Nd1	7302	-7260
Ndufs4	7231	-7266
Atp5c1	7307	-7106
Ndufa10	7196	-7177
mt-Nd2	7156	-7178
mt-Nd4	7500	-6841
Cox7a2l	7475	-6863
Atp5pb	6940	-7332
Ndufb5	7653	-6548
Idh3a	7599	-6565
mt-Co2	7209	-6779
mt-Nd6	7404	-6545
Coq10b	7726	-6242
Pdha1	6983	-6895
Ndufaf1	6861	-7005

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acad9	-223	1893	1304	8381	-2269
Aco2	-2899	4017	-767	8125	-3592
Adhfe1	2108	4266	-5076	7871	-3749
Atp5a1	3262	7568	-5776	6435	-3166
Atp5b	2582	7635	-6207	5299	-4926
Atp5c1	3292	7307	-7106	6710	-7264
Atp5d	4951	1682	1456	-4844	-1506
Atp5e	6877	1262	-3048	-6028	971
Atp5g1	3142	1013	4292	1069	362
Atp5g2	7812	-2852	6008	-4688	732
Atp5g3	5588	4002	-5344	-1122	-3371
Atp5h	5831	5803	-6891	-3998	-5000
Atp5j	3596	3600	-5770	-2772	-1275
Atp5j2	3633	1314	-3475	-3389	-2122
Atp5k	6671	340	5011	-6474	2071
Atp5l	6035	1630	-5466	365	-5546
Atp5o	89	3793	-4474	-1017	-5635
Atp5pb	768	6940	-7332	3309	-7064
Bsg	3055	3185	-5924	-4260	-4780
Coq10a	1573	5133	519	-5436	-3679
Coq10b	5602	7726	-6242	7945	-5654
Cox11	1249	-6666	1030	4410	-817
Cox14	1993	-2144	-2254	-6083	-3804
Cox16	5116	4514	-5737	-650	-6477
Cox18	2728	3993	5552	8672	1514
Cox19	-964	-4173	-1598	-3118	1112
Cox20	4825	5091	-7142	-5875	-922
Cox4i1	5753	396	-3643	-2518	-1901
Cox5a	4853	6817	-3957	-1299	-5294
Cox5b	5594	5057	476	-6694	1155
Cox6a1	6832	6258	-938	-4507	-2166
Cox6b1	5129	1661	-1189	-4988	-3968
Cox6c	4664	4699	-5263	-3484	-905
Cox7a2l	5823	7475	-6863	-2785	-2170
Cox7b	2532	4317	-6490	-4314	-5047
Cox7c	4841	5582	-3906	-4573	-1845
Cox8a	5258	4350	626	-4321	2681
Cs	-6854	4758	-2380	5087	-633
Cyc1	5209	2215	696	4721	-4027
Cycs	1051	7060	-7801	-4517	-7336
D2hgdh	-528	-1082	5702	-1117	5725
Dlat	-3062	7312	-4101	-546	-6310
Dld	-3369	4393	-7580	8197	-7367
Dlst	7102	-334	2489	5887	1979
Dmac2l	1831	2674	-6907	-2690	-7271
Ecsit	5804	2233	5022	-1686	-733
Etfa	3336	2980	-6849	5562	-5753
Etfb	5301	1904	-4962	-4889	846
Etfdh	-4235	1052	-4450	7841	-4442
Fahd1	5601	1492	-5762	-3589	-7106
Fh1	3681	4950	-7203	8633	-4238
Glo1	3359	6445	-7118	410	-4244
Gstz1	2457	-4046	-1765	-2761	1470
Hagh	1434	1547	-351	1361	-3024
Idh2	7942	6011	6239	7609	8327
Idh3a	-5972	7599	-6565	8335	-5870
Idh3b	-309	-2320	-331	7275	-3421
Idh3g	-5879	-2054	4003	4685	-5533
L2hgdh	-3485	-1805	-4211	3364	601
Ldha	2221	-105	-4898	-608	5791
Ldhb	2509	5670	-4419	3946	-4978
Lrpprc	-5904	-6513	-1170	5620	-2061
Mdh2	3352	3522	153	2092	-3797
Me1	1273	5511	-6492	8464	-5999
Me2	-4208	3298	-4299	5870	-2041
Me3	-5548	51	856	-876	-6657
Mpc1	3970	6934	-6443	2713	-6483
Mpc2	3952	5116	-6949	3042	-4998
mt-Atp6	5940	6271	-6901	-2603	-4261
mt-Atp8	7481	6134	-19	-4240	7577
mt-Co1	6249	7586	-7594	1523	-2152
mt-Co2	5704	7209	-6779	710	-7001
mt-Co3	5441	7001	-6527	-442	-4784
mt-Cytb	5768	7126	-6685	-491	-3196
mt-Nd1	5713	7302	-7260	-2321	-4387
mt-Nd2	6172	7156	-7178	-1628	-4326
mt-Nd3	7338	7408	-7692	-6838	4152
mt-Nd4	6182	7500	-6841	-1057	-3593
mt-Nd5	6493	7228	-6218	323	-1728
mt-Nd6	6945	7404	-6545	-3133	-5124
Ndufa1	6748	2683	-2157	-6312	-902
Ndufa10	-2897	7196	-7177	-8	-6008
Ndufa11	4792	-871	692	-2900	-4202
Ndufa12	3413	7278	-5426	-6561	747
Ndufa13	4996	5598	-100	-5974	3052
Ndufa2	7371	-1281	108	-3657	175
Ndufa3	5608	-178	3145	-6520	2194
Ndufa4	4005	6649	-6249	-3410	-3888
Ndufa5	4783	6832	-5305	-6066	-2584
Ndufa6	5333	4559	-3641	-3899	-670
Ndufa7	5517	4328	-848	-4994	618
Ndufa8	3073	1617	-5818	-3234	-821
Ndufa9	822	-1091	-5788	788	-3697
Ndufab1	5138	5377	-1496	-5020	-5347
Ndufaf1	6360	6861	-7005	5350	-6793
Ndufaf2	1250	5934	-7515	-5946	-5312
Ndufaf3	4091	-1081	-921	-2258	1465
Ndufaf4	-1872	7584	-7296	5310	-7177
Ndufaf5	6835	5439	-6668	3096	-6429
Ndufaf6	5592	6329	-4057	6158	-5061
Ndufaf7	6166	-1131	-2436	3536	3759
Ndufb1	6050	3264	-1698	-1495	263
Ndufb10	6236	295	87	-1804	-4747
Ndufb11	6181	6214	-4333	-1648	-4319
Ndufb2	7124	1176	-4656	-3516	-3368
Ndufb3	1908	2378	-5583	-2622	-3149
Ndufb4	5445	6291	-7104	-1955	-1676
Ndufb5	4388	7653	-6548	-596	-5664
Ndufb6	4456	3992	-6276	-853	-4951
Ndufb7	4615	1304	-627	-4767	477
Ndufb8	5591	5933	-4212	863	-3294
Ndufb9	6090	6480	-5430	-3373	-2917
Ndufc1	5478	7588	-6005	-6115	-2867
Ndufc2	5494	4599	-7660	2155	-5168
Ndufs1	-3681	6122	-4475	7932	-5117
Ndufs2	3517	7230	-5627	404	-291
Ndufs3	6665	5749	-3259	-3885	-4643
Ndufs4	3314	7231	-7266	-2564	-5435
Ndufs5	5009	4501	-4850	-3720	-3995
Ndufs6	5790	3657	-4612	-5998	876
Ndufs7	3851	2005	2704	-5631	491
Ndufs8	2820	330	-3399	276	-5754
Ndufv1	6127	3311	-2255	-132	-1731
Ndufv2	2239	7606	-7699	-248	-6975
Ndufv3	2871	189	1198	-6385	479
Nnt	2533	3840	-302	1500	417
Nubpl	3659	22	-5925	-2804	-3792
Ogdh	-5192	3616	2213	4380	2599
Pdha1	-5483	6983	-6895	7725	-4991
Pdhb	-3010	4915	-6856	4881	-6777
Pdhx	-435	4619	-5034	5918	-5021
Pdk1	-1756	-7826	3614	-3823	8281
Pdk2	-2394	309	1908	5638	3894
Pdk3	-545	7682	-4971	8055	-6438
Pdk4	1380	5735	-2664	1965	3632
Pdp1	4490	5584	-6311	7709	-4582
Pdp2	-2826	-6528	-3666	-3986	3424
Pdpr	-3764	-2756	3733	4282	2953
Pm20d1	6710	4549	-1801	8437	2254
Ppard	3115	3104	7501	2670	7552
Rxra	5014	6033	5444	7066	8253
Sco1	-5382	82	-6610	-5704	-5595
Sco2	-1098	5751	-3041	-4643	-34
Sdha	-4233	4992	-3689	6522	1446
Sdhb	2637	4258	-3153	1534	-5564
Sdhc	4354	7451	-5451	1260	-1331
Sdhd	2384	4786	-4481	4687	-2483
Slc16a1	-5944	3852	-7790	-4738	-7414
Slc16a3	-6811	-1864	-761	2143	7078
Slc16a8	-5523	-7070	5749	-1318	-2476
Slc25a14	7414	6547	-6519	1919	917
Slc25a27	-6853	-6157	6733	2556	1526
Sucla2	1547	6618	-6920	7368	-7297
Suclg1	5822	5080	-4978	920	-5991
Suclg2	7900	6790	-6547	8136	5837
Surf1	6478	6724	-4191	10	-2819
Taco1	3663	4753	5597	5251	-2135
Timmdc1	6227	7077	-1523	4744	115
Tmem126b	-1107	3082	-4188	1889	-2208
Tmem186	-6616	-6830	5069	-23	6134
Trap1	2488	-260	6072	6860	-808
Ucp2	7105	6439	6892	4530	8024
Ucp3	-5310	3826	-7173	5653	-4313
Uqcr10	5292	896	-573	-5544	919
Uqcr11	5354	-835	946	-5647	931
Uqcrb	2765	7015	-5638	-6224	-3361
Uqcrc1	3407	783	1790	127	-1970
Uqcrc2	-1039	5255	-7456	8035	-6300
Uqcrfs1	1309	3713	-825	-1154	-5659
Uqcrh	5525	3146	-4078	-3419	-3583
Uqcrq	5570	4202	-2706	-5676	-40
Vdac1	-1449	5622	-6800	2618	-3740

---

---

REGULATION OF EXPRESSION OF SLITS AND ROBOS

REGULATION OF EXPRESSION OF SLITS AND ROBOS

metric	value
setSize	160
pMANOVA	2.28e-44
p.adjustMANOVA	3.3e-42
s.dist	0.777
s.hyp	0.476
s.amy	0.362
s.hip	-0.441
s.pag	-0.212
s.ni	-0.0864
p.hyp	2.99e-25
p.amy	2.61e-15
p.hip	6.54e-22
p.pag	3.63e-06
p.ni	0.0597

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hyp	hip
Rpl22l1	6910	-7617
Rpl3	7453	-6914
Psma3	6690	-7489
Rpl27a	6828	-7291
Rps24	6709	-7080
Rpl35a	6018	-7800
Rps3a1	6918	-6743
Psme2	7552	-6094
Rpl30	5836	-7767
Rplp0	5928	-7544
Magoh	7231	-6150
Psmd14	6264	-7045
Rps6	6942	-6281
Rbm8a	5811	-7451
Rps3	7020	-6127
Psmd10	6335	-6730
Rps27a	7082	-6010
Rpl13a	6979	-6060
Rps8	6897	-6092
Rpl36a	5904	-7112

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Casc3	-3777	-7687	6714	-2911	5522
Col4a5	2303	164	4807	2371	464
Cul2	-3553	4505	-6428	8646	-5584
Dag1	861	5974	1793	6641	5239
Eif4a3	3291	4308	-1393	4990	1088
Eif4g1	-2094	-6038	3643	39	6315
Elob	5908	3940	-2825	-4924	-2779
Eloc	1015	5167	-7417	-3913	-6715
Etf1	-5025	4918	-6801	1360	-5207
Fau	6947	5500	-3002	-4268	2265
Gspt1	-2199	4680	1982	6293	-1788
Gspt2	-4477	-2824	259	4159	-1368
Isl1	5559	7532	-4343	2292	7991
Ldb1	-2377	-4224	6357	-3985	7671
Lhx2	-4399	-4673	2396	2854	-1825
Lhx9	-5881	-2321	1174	813	1280
Magoh	7231	-2219	-6150	3231	-6791
Magohb	-6312	4537	-3668	-1775	-6283
Msi1	-3761	-6086	5051	-6712	6329
Ncbp1	6212	4119	2873	8014	3608
Ncbp2	-4958	-1966	-7185	1839	-5507
Pabpc1	5166	6209	-6820	-150	1038
Psma1	5607	5571	-6202	4742	-6763
Psma2	4297	5066	-6869	4103	-6534
Psma3	6690	6047	-7489	-1552	-2237
Psma4	1746	4585	-6654	-1796	-5553
Psma5	3323	-1473	-6617	3568	-4793
Psma6	4242	5431	-7561	5365	-5733
Psma7	4349	2254	-4973	-1616	-2289
Psmb1	5425	6833	-7081	1876	-5399
Psmb10	5365	-1177	-2384	-3876	1032
Psmb2	6874	4672	1134	-1064	290
Psmb3	5156	749	-798	-1635	-2799
Psmb4	5774	5078	-3788	-2700	2441
Psmb5	5739	552	3826	-5060	1805
Psmb6	5243	-395	-1575	-982	-213
Psmb7	5789	3930	-6836	521	-5745
Psmb8	3419	2737	-6298	-2899	3478
Psmb9	840	-4742	-2793	-4571	167
Psmc1	1283	7563	-7755	-3571	-2837
Psmc2	399	6671	-6314	1438	-4043
Psmc3	5783	1161	-2887	2024	-4416
Psmc4	5458	8	2121	456	273
Psmc5	6184	5195	-4266	1972	-5212
Psmc6	-4950	6648	-7434	8559	-7419
Psmd1	-1911	7525	-6549	-2341	-251
Psmd10	6335	1117	-6730	3842	-5683
Psmd11	770	979	600	-3451	-1053
Psmd12	-7349	6212	-7689	6526	-7219
Psmd13	6487	-1504	-1320	4366	-2360
Psmd14	6264	5293	-7045	6717	-6868
Psmd2	-866	-163	-93	7544	1305
Psmd3	6427	-50	6650	4129	3084
Psmd4	3270	646	1379	-3445	2190
Psmd5	-1202	4465	-2978	7366	-2873
Psmd6	4799	5502	-6924	6782	-5318
Psmd7	5456	5674	-6186	-2000	2853
Psmd8	5672	7148	-5941	527	-6056
Psmd9	6231	3555	169	-2328	6272
Psme1	4251	89	-2892	-1727	7025
Psme2	7552	1605	-6094	-5627	-1591
Psme3	3041	4955	-3094	1531	-1448
Psme4	-2266	-7768	3279	1953	-3258
Psmf1	-357	3225	355	-1462	-3411
Rbm8a	5811	7279	-7451	-4580	-2718
Rbx1	1681	5617	-6295	-3314	-4296
Rnps1	-1894	1589	835	-2072	4412
Robo1	-2991	1523	3972	1416	3473
Robo2	-4861	1007	1733	-138	-1216
Robo3	-5610	-5612	2991	-2415	4154
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Sem1	6677	1611	-3004	-2721	-2140
Slit1	-6538	-6661	7873	3771	6634
Slit2	-4400	-6573	-4050	4734	4864
Uba52	6848	4468	-3633	-6717	4906
Ubb	78	4259	-1569	-1900	-1839
Ubc	-6659	-637	164	5564	729
Upf2	-48	-5583	-3729	-6137	1775
Upf3a	-1349	-3139	-2142	-3871	4799
Upf3b	-563	1991	-6125	-6208	2890
Usp33	-3778	5412	-2819	8239	-6345
Zswim8	-3472	-6985	7722	1208	7104

---

---

CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING

metric	value
setSize	16
pMANOVA	0.00614
p.adjustMANOVA	0.0211
s.dist	0.774
s.hyp	-0.126
s.amy	-0.516
s.hip	0.485
s.pag	-0.0984
s.ni	0.269
p.hyp	0.383
p.amy	0.000355
p.hip	0.000787
p.pag	0.495
p.ni	0.0621

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	hip
Plxna3	-7418	7387
Plxna1	-7019	7695
Plxna4	-7504	6441
Dpysl5	-5296	7883
Dpysl4	-5849	7074
Crmp1	-5954	5665
Plxna2	-4148	6469
Nrp1	-3671	5556
Dpysl2	-6749	2625
Cdk5	-4073	2352
Fes	-686	6721

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cdk5	4279	-4073	2352	-1051	-2368
Cdk5r1	-3993	-2237	-276	-5170	99
Crmp1	-6232	-5954	5665	3348	3681
Dpysl2	7487	-6749	2625	-6761	5495
Dpysl3	-1879	-5592	-1502	-3972	2384
Dpysl4	2237	-5849	7074	990	4106
Dpysl5	-2520	-5296	7883	1700	8098
Fes	7915	-686	6721	858	3892
Fyn	-2945	222	913	8170	924
Gsk3b	-1835	-1738	-125	-3714	-790
Nrp1	-4625	-3671	5556	-284	3966
Plxna1	-5900	-7019	7695	2779	7377
Plxna2	-2057	-4148	6469	3089	1917
Plxna3	402	-7418	7387	539	4155
Plxna4	-4260	-7504	6441	-4674	5865
Sema3a	-496	829	-1872	7022	-6993

---

---

BLOOD GROUP SYSTEMS BIOSYNTHESIS

BLOOD GROUP SYSTEMS BIOSYNTHESIS

metric	value
setSize	12
pMANOVA	0.0113
p.adjustMANOVA	0.0346
s.dist	0.766
s.hyp	-0.0544
s.amy	0.517
s.hip	-0.198
s.pag	0.418
s.ni	-0.321
p.hyp	0.744
p.amy	0.00194
p.hip	0.235
p.pag	0.0121
p.ni	0.0543

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	pag
St3gal4	7800	8138
B3galt2	6207	8815
B3galt5	6261	7547
Fut10	3791	8632
Fut11	4462	6446
Fut9	5007	4869
St6galnac6	3005	7398
B3galt1	5064	3608
St3gal3	1084	7895

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
B3galt1	-1781	5064	-4036	3608	-3662
B3galt2	-6333	6207	-7066	8815	-6653
B3galt4	-3964	-1871	-1636	-2014	-2955
B3galt5	-1455	6261	5390	7547	-891
Fut10	-713	3791	-3257	8632	2020
Fut11	-1883	4462	2912	6446	-1947
Fut2	-4955	2013	-3128	-3423	-3240
Fut9	2921	5007	-7123	4869	-7132
St3gal3	-970	1084	7426	7895	129
St3gal4	7909	7800	-406	8138	-484
St3gal6	1689	5155	-7673	-6617	-6131
St6galnac6	5519	3005	934	7398	6191

---

---

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

metric	value
setSize	13
pMANOVA	0.00109
p.adjustMANOVA	0.00538
s.dist	0.764
s.hyp	0.288
s.amy	0.271
s.hip	-0.64
s.pag	-0.0338
s.ni	-0.125
p.hyp	0.0723
p.amy	0.0906
p.hip	6.42e-05
p.pag	0.833
p.ni	0.433

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	hyp
Spcs1	-6134	7109
Spcs2	-7758	4596
Sec11c	-4788	5062
Isl1	-4343	5559
Sec11a	-5918	2811
Gng13	-2000	5363
Dpp4	-7319	1135
Ctnnb1	-2365	2913
Tcf7l2	-3519	1543
Grp	-4257	306

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ctnnb1	2913	-460	-2365	8252	5469
Dpp4	1135	-5685	-7319	-5571	-4024
Gng13	5363	876	-2000	-6509	1166
Grp	306	-4798	-4257	-4530	1127
Isl1	5559	7532	-4343	2292	7991
Pax6	-4491	-3069	-3081	1637	-6730
Pcsk1	-58	1039	-5948	8532	1457
Sec11a	2811	777	-5918	4142	3313
Sec11c	5062	6540	-4788	-1445	-4514
Spcs1	7109	7676	-6134	-1457	-3637
Spcs2	4596	5236	-7758	-940	-1235
Spcs3	-951	5788	-7226	8019	-4668
Tcf7l2	1543	5218	-3519	-3433	-2411

---

---

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

metric	value
setSize	12
pMANOVA	0.00315
p.adjustMANOVA	0.0127
s.dist	0.76
s.hyp	0.254
s.amy	0.213
s.hip	-0.647
s.pag	-0.0506
s.ni	-0.215
p.hyp	0.127
p.amy	0.201
p.hip	0.000105
p.pag	0.762
p.ni	0.197

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	hyp
Spcs1	-6134	7109
Spcs2	-7758	4596
Sec11c	-4788	5062
Sec11a	-5918	2811
Gng13	-2000	5363
Dpp4	-7319	1135
Ctnnb1	-2365	2913
Tcf7l2	-3519	1543
Grp	-4257	306

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ctnnb1	2913	-460	-2365	8252	5469
Dpp4	1135	-5685	-7319	-5571	-4024
Gng13	5363	876	-2000	-6509	1166
Grp	306	-4798	-4257	-4530	1127
Pax6	-4491	-3069	-3081	1637	-6730
Pcsk1	-58	1039	-5948	8532	1457
Sec11a	2811	777	-5918	4142	3313
Sec11c	5062	6540	-4788	-1445	-4514
Spcs1	7109	7676	-6134	-1457	-3637
Spcs2	4596	5236	-7758	-940	-1235
Spcs3	-951	5788	-7226	8019	-4668
Tcf7l2	1543	5218	-3519	-3433	-2411

---

---

RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE

metric	value
setSize	10
pMANOVA	0.0314
p.adjustMANOVA	0.0774
s.dist	0.757
s.hyp	-0.0796
s.amy	0.478
s.hip	-0.321
s.pag	0.446
s.ni	-0.191
p.hyp	0.663
p.amy	0.00886
p.hip	0.0791
p.pag	0.0145
p.ni	0.295

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	amy	pag
Cul3	7166	7742
Plin3	7580	6343
Rhobtb3	7216	6333
Lrrc41	2604	7441
Rab9b	4521	4116
Htr7	2143	8600
Vhl	5004	2402
Hgs	581	5496

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ccne1	-7295	-6517	-669	-2399	-3320
Cul3	-5619	7166	-6984	7742	-7238
Hgs	-5491	581	5656	5496	4648
Htr7	-2050	2143	-1098	8600	2492
Lrrc41	-4377	2604	1243	7441	4506
Plin3	7408	7580	-3036	6343	6699
Rab9	721	6617	-7162	-1124	-6441
Rab9b	506	4521	-1354	4116	-2197
Rhobtb3	3734	7216	-6528	6333	-6602
Vhl	7112	5004	-4499	2402	-2909

---

---

PROTEIN METHYLATION

PROTEIN METHYLATION

metric	value
setSize	17
pMANOVA	0.00543
p.adjustMANOVA	0.0194
s.dist	0.754
s.hyp	0.295
s.amy	0.444
s.hip	-0.467
s.pag	0.129
s.ni	-0.224
p.hyp	0.0352
p.amy	0.00153
p.hip	0.000867
p.pag	0.356
p.ni	0.109

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	amy
Calm1	-7742	5302
Vcp	-5896	6851
Hspa8	-7401	5112
Kin	-6724	5459
Eef1a1	-5330	6785
Eef1akmt2	-6771	3609
Eef1akmt1	-4369	4679
Camkmt	-2549	5486
Rps2	-7253	1347
Etfb	-4962	1904
Mettl21a	-1747	3419
Eef2	-692	5021
Vcpkmt	-6721	169

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Calm1	1413	5302	-7742	-2752	-6838
Camkmt	-6874	5486	-2549	8420	-2311
Eef1a1	5842	6785	-5330	5852	3484
Eef1akmt1	4081	4679	-4369	1362	-4699
Eef1akmt2	6239	3609	-6771	6847	906
Eef2	4314	5021	-692	5851	6537
Eef2kmt	5953	-2164	2133	-4277	1132
Etfb	5301	1904	-4962	-4889	846
Etfbkmt	2973	-934	-4839	5607	1991
Hspa8	-4013	5112	-7401	953	-5665
Kin	-3924	5459	-6724	-5730	-6136
Mettl21a	3074	3419	-1747	6642	2463
Mettl22	5459	1242	4968	7072	-2542
Prmt3	1358	4861	4745	2392	-4513
Rps2	1985	1347	-7253	-3792	-2992
Vcp	2537	6851	-5896	4206	2964
Vcpkmt	5650	169	-6721	-33	-6709

---

---

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

metric	value
setSize	31
pMANOVA	7.67e-06
p.adjustMANOVA	7.18e-05
s.dist	0.747
s.hyp	0.223
s.amy	0.303
s.hip	-0.55
s.pag	-0.083
s.ni	-0.329
p.hyp	0.0319
p.amy	0.00347
p.hip	1.18e-07
p.pag	0.424
p.ni	0.00154

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Cdc42	-7712	-7012
Tcp1	-7732	-6098
Hnrnpdl	-7406	-6325
Mtap	-6321	-6892
Rap1b	-7354	-5669
Ppia	-7329	-5258
Rala	-6926	-5246
Lcp1	-5397	-6704
Capza1	-5352	-6347
Hnrnpa2b1	-6870	-4752
Hspa9	-6953	-2333
Taldo1	-3497	-4378
Cfl1	-2773	-4822
Gsto1	-5110	-2262
Snrpa1	-4805	-2399
Psme2	-6094	-1591
Pdcd4	-6488	-1305
Pitpna	-1562	-5077
Aip	-2408	-1713
Arf1	-520	-3486

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Aip	1385	-4378	-2408	429	-1713
Anxa2	6859	909	463	-493	5079
Arf1	1959	4500	-520	4569	-3486
Bola2	7024	-1849	-8	-3810	965
Capza1	-5518	4773	-5352	3919	-6347
Cdc42	3471	6102	-7712	4032	-7012
Cfl1	267	2235	-2773	802	-4822
Cnn2	3701	5609	-4628	-4972	2047
Gsto1	7060	6849	-5110	2524	-2262
Hnrnpa2b1	-1271	-5297	-6870	-2056	-4752
Hnrnpdl	-7126	-5624	-7406	-4078	-6325
Hnrnpf	6512	264	-4304	7946	6589
Hspa9	-4747	4262	-6953	3404	-2333
Lcp1	-5436	2574	-5397	-6277	-6704
Lmnb1	-3675	-7598	1337	3413	5183
Mif	4003	530	3678	-4795	-730
Msn	7690	6654	-1159	-1759	3286
Mtap	-5830	5198	-6321	4100	-6892
Pak2	1092	7648	-4609	8226	-21
Pdcd4	5520	-1377	-6488	-6329	-1305
Pitpna	-6166	-5730	-1562	594	-5077
Ppia	3805	5239	-7329	-1038	-5258
Psme2	7552	1605	-6094	-5627	-1591
Rala	-3517	2930	-6926	3968	-5246
Rap1b	5737	6708	-7354	7351	-5669
Rplp0	5928	5641	-7544	-1113	-209
Snrpa1	6229	4772	-4805	-3104	-2399
Sod1	5319	5474	-2953	-5293	1246
Sod2	2929	-196	-3442	-6004	436
Taldo1	5294	5306	-3497	3140	-4378
Tcp1	1566	7701	-7732	7689	-6098

---

---

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

metric	value
setSize	12
pMANOVA	0.00655
p.adjustMANOVA	0.0223
s.dist	0.741
s.hyp	0.0634
s.amy	0.466
s.hip	-0.523
s.pag	0.215
s.ni	-0.0853
p.hyp	0.704
p.amy	0.00517
p.hip	0.00169
p.pag	0.196
p.ni	0.609

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	amy
Pla2g7	-7668	7363
Spcs1	-6134	7676
Spcs3	-7226	5788
Spcs2	-7758	5236
Sec11c	-4788	6540
Klf4	-2132	5723
Pcsk1	-5948	1039
Sec11a	-5918	777
Bche	-5309	586

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Ache	-2147	6240	4097	3951	7145
Bche	-2587	586	-5309	1168	-4771
Crhr2	-1889	-1507	3427	1642	7328
Igf1	-6455	-2290	-3226	-4537	680
Klf4	6589	5723	-2132	5768	3870
Pcsk1	-58	1039	-5948	8532	1457
Pla2g7	-4900	7363	-7668	7144	-7330
Sec11a	2811	777	-5918	4142	3313
Sec11c	5062	6540	-4788	-1445	-4514
Spcs1	7109	7676	-6134	-1457	-3637
Spcs2	4596	5236	-7758	-940	-1235
Spcs3	-951	5788	-7226	8019	-4668

---

---

METABOLISM OF POLYAMINES

METABOLISM OF POLYAMINES

metric	value
setSize	57
pMANOVA	3.23e-10
p.adjustMANOVA	8.91e-09
s.dist	0.739
s.hyp	0.354
s.amy	0.391
s.hip	-0.429
s.pag	0.0383
s.ni	-0.285
p.hyp	3.78e-06
p.amy	3.21e-07
p.hip	2.08e-08
p.pag	0.617
p.ni	0.000199

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	amy
Psmc1	-7755	7563
Amd1	-7577	7558
Psmc6	-7434	6648
Psmd1	-6549	7525
Psmb1	-7081	6833
Psmd12	-7689	6212
Psma3	-7489	6047
Psmd8	-5941	7148
Psmc2	-6314	6671
Psma6	-7561	5431
Nqo1	-5503	6955
Psmd6	-6924	5502
Psmd14	-7045	5293
Psmd7	-6186	5674
Psma2	-6869	5066
Psma1	-6202	5571
Psma4	-6654	4585
Sms	-7265	3833
Psmb7	-6836	3930
Azin1	-4249	6239

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Agmat	-955	4623	1814	-517	-5647
Amd1	1296	7558	-7577	5517	-5131
Azin1	6974	6239	-4249	8779	-6227
Azin2	-3543	-1870	4706	5602	4943
Nqo1	7979	6955	-5503	6509	-1784
Oaz1	6523	-700	-3669	1593	1473
Oaz2	1972	3270	-6414	-999	4
Oaz3	-7660	2559	-6584	-6877	7189
Odc1	2808	-834	-3583	5955	-146
Paox	-4499	2310	-3280	-555	-406
Psma1	5607	5571	-6202	4742	-6763
Psma2	4297	5066	-6869	4103	-6534
Psma3	6690	6047	-7489	-1552	-2237
Psma4	1746	4585	-6654	-1796	-5553
Psma5	3323	-1473	-6617	3568	-4793
Psma6	4242	5431	-7561	5365	-5733
Psma7	4349	2254	-4973	-1616	-2289
Psmb1	5425	6833	-7081	1876	-5399
Psmb10	5365	-1177	-2384	-3876	1032
Psmb2	6874	4672	1134	-1064	290
Psmb3	5156	749	-798	-1635	-2799
Psmb4	5774	5078	-3788	-2700	2441
Psmb5	5739	552	3826	-5060	1805
Psmb6	5243	-395	-1575	-982	-213
Psmb7	5789	3930	-6836	521	-5745
Psmb8	3419	2737	-6298	-2899	3478
Psmb9	840	-4742	-2793	-4571	167
Psmc1	1283	7563	-7755	-3571	-2837
Psmc2	399	6671	-6314	1438	-4043
Psmc3	5783	1161	-2887	2024	-4416
Psmc4	5458	8	2121	456	273
Psmc5	6184	5195	-4266	1972	-5212
Psmc6	-4950	6648	-7434	8559	-7419
Psmd1	-1911	7525	-6549	-2341	-251
Psmd10	6335	1117	-6730	3842	-5683
Psmd11	770	979	600	-3451	-1053
Psmd12	-7349	6212	-7689	6526	-7219
Psmd13	6487	-1504	-1320	4366	-2360
Psmd14	6264	5293	-7045	6717	-6868
Psmd2	-866	-163	-93	7544	1305
Psmd3	6427	-50	6650	4129	3084
Psmd4	3270	646	1379	-3445	2190
Psmd5	-1202	4465	-2978	7366	-2873
Psmd6	4799	5502	-6924	6782	-5318
Psmd7	5456	5674	-6186	-2000	2853
Psmd8	5672	7148	-5941	527	-6056
Psmd9	6231	3555	169	-2328	6272
Psme1	4251	89	-2892	-1727	7025
Psme2	7552	1605	-6094	-5627	-1591
Psme3	3041	4955	-3094	1531	-1448
Psme4	-2266	-7768	3279	1953	-3258
Psmf1	-357	3225	355	-1462	-3411
Sat1	496	1643	-7516	2658	-5916
Sem1	6677	1611	-3004	-2721	-2140
Smox	7827	7772	7997	8796	8292
Sms	-6158	3833	-7265	-64	-6863
Srm	-1467	4338	7026	6042	-1488

---

---

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

metric	value
setSize	12
pMANOVA	0.00434
p.adjustMANOVA	0.0162
s.dist	0.738
s.hyp	0.433
s.amy	0.444
s.hip	0.0931
s.pag	0.355
s.ni	0.161
p.hyp	0.00936
p.amy	0.00781
p.hip	0.577
p.pag	0.0333
p.ni	0.333

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hyp
Hsd3b7	7225	7902
Scp2	7349	6440
Ptgis	5826	7918
Cyp7b1	4516	7438
Rxra	6033	5014
Slc27a2	2481	6775
Hsd17b4	7112	1747
Amacr	2133	2555

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Acot8	6152	-1000	2981	-2565	5119
Amacr	2555	2133	-3079	5475	-4743
Cyp27a1	-4726	4236	2725	-2372	-3879
Cyp7b1	7438	4516	-4661	5107	419
Hsd17b4	1747	7112	-3024	8480	4140
Hsd3b7	7902	7225	155	8622	4687
Ncoa1	-2820	-2770	5132	-2380	2376
Ncoa2	-2056	-2129	5284	1273	1664
Ptgis	7918	5826	2072	5675	6565
Rxra	5014	6033	5444	7066	8253
Scp2	6440	7349	-6693	4018	-5247
Slc27a2	6775	2481	3687	6849	1727

---

---

NEGATIVE REGULATION OF NOTCH4 SIGNALING

NEGATIVE REGULATION OF NOTCH4 SIGNALING

metric	value
setSize	54
pMANOVA	7.11e-10
p.adjustMANOVA	1.81e-08
s.dist	0.737
s.hyp	0.349
s.amy	0.373
s.hip	-0.442
s.pag	-0.046
s.ni	-0.291
p.hyp	9.37e-06
p.amy	2.12e-06
p.hip	1.95e-08
p.pag	0.559
p.ni	0.000219

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	amy
Psmc1	-7755	7563
Skp1	-7782	7448
Psmc6	-7434	6648
Psmd1	-6549	7525
Psmb1	-7081	6833
Psmd12	-7689	6212
Psma3	-7489	6047
Psmd8	-5941	7148
Psmc2	-6314	6671
Psma6	-7561	5431
Psmd6	-6924	5502
Psmd14	-7045	5293
Rps27a	-6010	6031
Rbx1	-6295	5617
Psmd7	-6186	5674
Psma2	-6869	5066
Psma1	-6202	5571
Psma4	-6654	4585
Psmb7	-6836	3930
Psmc5	-4266	5195

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Akt1	-5048	1799	5347	6270	3464
Cul1	-7463	1004	-2558	8662	-6599
Fbxw7	-1324	-1588	-7694	-5518	-6506
Notch4	5655	2567	7283	-2460	7875
Psma1	5607	5571	-6202	4742	-6763
Psma2	4297	5066	-6869	4103	-6534
Psma3	6690	6047	-7489	-1552	-2237
Psma4	1746	4585	-6654	-1796	-5553
Psma5	3323	-1473	-6617	3568	-4793
Psma6	4242	5431	-7561	5365	-5733
Psma7	4349	2254	-4973	-1616	-2289
Psmb1	5425	6833	-7081	1876	-5399
Psmb10	5365	-1177	-2384	-3876	1032
Psmb2	6874	4672	1134	-1064	290
Psmb3	5156	749	-798	-1635	-2799
Psmb4	5774	5078	-3788	-2700	2441
Psmb5	5739	552	3826	-5060	1805
Psmb6	5243	-395	-1575	-982	-213
Psmb7	5789	3930	-6836	521	-5745
Psmb8	3419	2737	-6298	-2899	3478
Psmb9	840	-4742	-2793	-4571	167
Psmc1	1283	7563	-7755	-3571	-2837
Psmc2	399	6671	-6314	1438	-4043
Psmc3	5783	1161	-2887	2024	-4416
Psmc4	5458	8	2121	456	273
Psmc5	6184	5195	-4266	1972	-5212
Psmc6	-4950	6648	-7434	8559	-7419
Psmd1	-1911	7525	-6549	-2341	-251
Psmd10	6335	1117	-6730	3842	-5683
Psmd11	770	979	600	-3451	-1053
Psmd12	-7349	6212	-7689	6526	-7219
Psmd13	6487	-1504	-1320	4366	-2360
Psmd14	6264	5293	-7045	6717	-6868
Psmd2	-866	-163	-93	7544	1305
Psmd3	6427	-50	6650	4129	3084
Psmd4	3270	646	1379	-3445	2190
Psmd5	-1202	4465	-2978	7366	-2873
Psmd6	4799	5502	-6924	6782	-5318
Psmd7	5456	5674	-6186	-2000	2853
Psmd8	5672	7148	-5941	527	-6056
Psmd9	6231	3555	169	-2328	6272
Psme1	4251	89	-2892	-1727	7025
Psme2	7552	1605	-6094	-5627	-1591
Psme3	3041	4955	-3094	1531	-1448
Psmf1	-357	3225	355	-1462	-3411
Rbx1	1681	5617	-6295	-3314	-4296
Rps27a	7082	6031	-6010	-1860	-1558
Sem1	6677	1611	-3004	-2721	-2140
Skp1	1882	7448	-7782	3198	-6887
Tacc3	-5087	-7032	2126	8673	1179
Uba52	6848	4468	-3633	-6717	4906
Ubb	78	4259	-1569	-1900	-1839
Ubc	-6659	-637	164	5564	729
Ywhaz	725	-794	-5734	-5978	-2667

---

---

TRANSLATION

TRANSLATION

metric	value
setSize	286
pMANOVA	5.25e-62
p.adjustMANOVA	6.09e-59
s.dist	0.733
s.hyp	0.416
s.amy	0.372
s.hip	-0.419
s.pag	-0.116
s.ni	-0.193
p.hyp	1.08e-33
p.amy	2.72e-27
p.hip	3.25e-34
p.pag	0.000766
p.ni	2e-08

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	hyp
Eif3j2	-7681	7062
Rpl22l1	-7617	6910
Rpl3	-6914	7453
Rpl27a	-7291	6828
Ssr3	-6806	7259
Rps24	-7080	6709
Rpl35a	-7800	6018
Sec61g	-6252	7494
Rps3a1	-6743	6918
Mrps35	-6129	7590
Rpl30	-7767	5836
Mrps18c	-7293	6157
Rplp0	-7544	5928
Mrpl16	-6606	6606
Spcs1	-6134	7109
Rps6	-6281	6942
Mrpl32	-6618	6513
Rps3	-6127	7020
Rps27a	-6010	7082
Eif3m	-7483	5667

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Aars	-4871	3502	324	5912	667
Aars2	-2720	-5888	7343	-996	3917
Aimp1	5818	4633	-7059	-1374	-4460
Aimp2	7342	252	-423	922	-1134
Apeh	7823	4361	3310	2564	5952
Aurkaip1	4614	5558	-4160	-2251	-302
Cars	41	-1605	5309	-5537	936
Cars2	2370	-5224	6529	-3654	2730
Chchd1	6265	4829	-6374	-732	-5478
Dap3	5422	521	3037	5019	4724
Dars	-5223	5077	-6955	6211	-6616
Dars2	3033	2713	-3799	8550	-3074
Ddost	2689	5852	178	-222	6350
Ears2	1974	-6667	1760	8556	4626
Eef1a1	5842	6785	-5330	5852	3484
Eef1a2	-4543	6508	-920	6159	483
Eef1b2	6449	5199	-6303	899	-3563
Eef1d	6613	3278	-1430	-1603	2649
Eef1e1	5266	6859	-7819	3035	-5617
Eef1g	5281	7190	-7135	-2019	-2270
Eef2	4314	5021	-692	5851	6537
Eif1ax	-4860	3567	-6220	8683	-7135
Eif2b1	-5294	-2032	2331	5384	-4104
Eif2b2	1075	4302	6342	2202	7044
Eif2b3	418	-1265	-6348	-1028	-5689
Eif2b4	5390	2863	1933	-4310	-3771
Eif2b5	6017	3167	-2373	2012	-172
Eif2s1	-2005	7092	-7557	8513	-7288
Eif2s2	3576	7100	-7798	-5071	-5730
Eif2s3x	3605	7037	-6156	5582	-3408
Eif3a	-5466	-4407	-5548	-5485	7636
Eif3b	6719	1649	2792	-781	5677
Eif3c	379	2605	-2495	4508	2929
Eif3d	5187	133	-2159	-111	-1035
Eif3e	5337	6632	-7677	5703	-6209
Eif3f	7578	5504	-1607	232	1095
Eif3g	1911	4008	-4892	-1947	-1790
Eif3h	3909	5138	-6624	6093	-5024
Eif3i	5031	2168	260	584	-3998
Eif3j1	447	327	-3803	1564	-3314
Eif3j2	7062	7042	-7681	1110	-6231
Eif3k	4696	-1060	-2241	-2252	122
Eif3l	6167	3558	2184	2519	-2103
Eif3m	5667	6558	-7483	6973	-6901
Eif4a1	7214	2119	-3862	8473	-2901
Eif4a2	-1909	5569	-7748	8454	-7228
Eif4b	-2519	4029	-5314	7202	3034
Eif4e	3462	6423	-7632	5587	-5428
Eif4ebp1	4194	3037	-3086	6171	2112
Eif4g1	-2094	-6038	3643	39	6315
Eif4h	-20	-1019	1451	1662	6195
Eif5	-3507	4697	-7688	-4322	-7378
Eif5b	922	5213	-7771	-6788	3983
Eprs	-4003	822	-4649	-527	2284
Eral1	7643	1984	7056	-1829	3907
Etf1	-5025	4918	-6801	1360	-5207
Fars2	6474	-2266	-2794	2115	4056
Farsa	4493	-7230	5842	-2590	7046
Farsb	-4643	4419	-1840	1467	-5371
Fau	6947	5500	-3002	-4268	2265
Gadd45gip1	2721	-314	-1319	-4768	-2074
Gars	-4897	6893	-6884	3921	-6423
Gfm1	-3981	2934	-1188	3422	-4263
Gfm2	1938	-6044	3378	2703	-2849
Gspt1	-2199	4680	1982	6293	-1788
Gspt2	-4477	-2824	259	4159	-1368
Hars	-459	4886	-5910	6420	-2302
Hars2	1581	-1720	1886	5933	1140
Iars	-7223	-4949	5106	7856	1950
Iars2	872	835	2882	219	748
Kars	951	7674	-3116	2961	-4641
Lars	-4310	-5636	-1119	6071	5761
Lars2	7968	4780	3346	-6904	8136
Mars1	-2913	-6192	6211	7802	3197
Mars2	-186	-3264	-2810	3839	70
Mrpl1	-7180	5785	-7093	3986	-6756
Mrpl10	-1130	2987	-4379	-1158	-5372
Mrpl11	5623	3945	-5696	-3026	-4904
Mrpl12	5558	1587	-3993	-1298	-4227
Mrpl13	2856	6530	-6882	172	-4890
Mrpl14	6767	965	-622	-3628	1497
Mrpl15	4459	7744	-7346	3571	-5362
Mrpl16	6606	592	-6606	8092	-6578
Mrpl17	4331	5408	-4807	2562	-2570
Mrpl18	2427	4852	-5271	-355	-6341
Mrpl19	-1352	1193	-6677	-3829	-1801
Mrpl2	4079	3305	691	-1588	996
Mrpl20	4103	-706	-338	-3008	-3121
Mrpl21	3581	2583	-2101	-4468	-4439
Mrpl22	-3188	4925	-2252	3053	-6077
Mrpl23	7765	926	-4397	-4350	-180
Mrpl24	5257	4555	-4501	-3880	-626
Mrpl27	3428	-2046	-2424	-3074	-3272
Mrpl28	5330	4610	-1730	-3889	-2167
Mrpl3	1821	-797	-4432	5610	-6752
Mrpl30	2375	6915	-5619	-771	-4228
Mrpl32	6513	6674	-6618	2593	-6809
Mrpl33	4620	4415	-6854	-4559	-3789
Mrpl34	5231	7084	-6329	319	-5043
Mrpl35	6296	3589	-5857	2459	-5254
Mrpl36	6196	355	-1090	526	-4108
Mrpl37	5532	-1016	5134	6906	-3081
Mrpl38	234	960	2806	-706	3778
Mrpl39	-775	4606	-5903	1227	-4147
Mrpl4	5367	-1136	6689	743	-1215
Mrpl40	654	3611	-5048	-183	-6024
Mrpl41	5152	2196	-2580	-2538	-473
Mrpl42	4377	6564	-5767	-1982	-6769
Mrpl43	5126	3937	-4197	-1599	-3613
Mrpl44	-3002	4167	-3913	-2586	-1922
Mrpl46	5012	2592	-2727	-1258	-4213
Mrpl47	6600	6553	-6362	351	-7022
Mrpl48	4333	7385	-7130	-5143	-4345
Mrpl49	502	1746	-3363	3402	-3181
Mrpl50	961	5197	-7620	2550	-6396
Mrpl51	7706	5529	-3027	-5202	-4235
Mrpl52	6885	3949	-1776	-2920	-897
Mrpl53	5845	-1841	240	-2805	-1609
Mrpl54	4385	6380	-5934	-4566	-2638
Mrpl55	-4626	-978	-565	-5397	-1688
Mrpl57	4424	1934	824	-4638	-1423
Mrpl58	1876	-766	1780	-2469	-724
Mrpl9	7161	-3585	-3016	2971	-1533
Mrps10	215	6505	-5898	-4124	-2965
Mrps11	2035	-159	1668	-561	-1267
Mrps12	587	-103	-673	-3990	-3420
Mrps14	4296	4596	-5437	-71	-5449
Mrps15	5881	6006	-632	-595	-389
Mrps16	4563	1621	-3782	-669	-756
Mrps17	5914	45	-2768	-3134	-498
Mrps18a	738	4320	-3886	-2802	-3970
Mrps18b	1745	901	-4179	-4604	-3322
Mrps18c	6157	3948	-7293	-2161	-3898
Mrps2	-680	6954	-5197	-5971	-6985
Mrps21	4229	1794	-2311	-6161	-2709
Mrps22	1963	6322	-7538	4375	-6545
Mrps23	5781	2986	-6808	-4095	-5142
Mrps24	3534	4279	-2133	-1323	-1553
Mrps25	1238	1177	-6179	-2179	-1114
Mrps26	3479	-1196	-227	-2827	883
Mrps27	4179	-1009	3554	-1849	-3929
Mrps28	416	-534	-3744	2386	-134
Mrps30	5315	5329	-7474	7828	-6716
Mrps31	-6681	7791	-7583	8342	-6183
Mrps33	4155	4824	-5212	-3519	-4045
Mrps34	3689	-2324	1714	-4722	1723
Mrps35	7590	3520	-6129	551	-3984
Mrps36	105	7224	-6966	-949	-4577
Mrps5	-6448	4312	-6132	-2536	1182
Mrps6	7257	3069	-3408	2692	879
Mrps7	4786	3072	-4770	673	-2045
Mrps9	6323	2200	-3785	-1118	-2722
Mrrf	-1483	2373	-1183	5136	-6128
Mtfmt	2569	2833	1542	-5841	596
Mtif2	48	-3945	-4339	4828	-7027
Mtif3	-4103	403	-5729	-1995	-240
Mtrf1l	2220	-622	-4687	5297	5812
N6amt1	-1260	-5605	-7785	-6795	-3379
Nars	-1699	4078	-7468	720	-6113
Nars2	3	3786	14	7543	-4478
Oxa1l	3527	5319	5555	-1537	-2316
Pabpc1	5166	6209	-6820	-150	1038
Pars2	3736	-117	1388	-752	6887
Ppa1	3979	6360	-7747	289	-6842
Ppa2	2311	4223	-6539	3694	-6648
Ptcd3	-7512	3653	-7026	6757	-7248
Qars	6732	1265	5833	8728	4238
Rars	-2965	1416	-7154	1906	-4217
Rars2	-1914	-6544	-3741	1929	1773
Rpl10	5452	-3514	468	8620	7197
Rpl10a	5664	690	-4425	-6301	5665
Rpl11	5347	5070	-5844	1153	-415
Rpl12	4562	-7052	865	-4860	1444
Rpl13	6714	3083	-1790	702	3582
Rpl13a	6979	5871	-6060	-2570	1551
Rpl14	6154	5294	-5792	-2395	-1459
Rpl15	5110	2877	-6642	-3812	-869
Rpl17	5895	5359	-6058	316	-3731
Rpl18	6358	247	-2697	-1047	-742
Rpl18a	6733	5120	-5105	-1206	822
Rpl19	6401	3402	-3400	-1735	49
Rpl21	5968	2548	-4619	6068	-5097
Rpl22	5188	5628	-5699	1686	-3690
Rpl22l1	6910	6668	-7617	-1468	-4413
Rpl23	6429	6255	-5014	-4040	282
Rpl23a	6100	7281	-5118	228	-2553
Rpl24	5486	7252	-6236	-3350	-3972
Rpl26	5085	3464	-7018	-4432	4103
Rpl27	6544	4982	-4604	-2576	3449
Rpl27a	6828	2653	-7291	-1354	292
Rpl28	3882	791	-3622	-5529	3942
Rpl29	4491	3491	-7079	-4821	484
Rpl3	7453	5684	-6914	-6592	2428
Rpl30	5836	4970	-7767	-3476	2228
Rpl31	6276	5447	-4774	-5954	4214
Rpl32	6368	4417	-3351	-3615	694
Rpl34	6550	3349	-2765	-634	-1306
Rpl35	7154	4071	-1706	-3649	1717
Rpl35a	6018	5247	-7800	-2635	2094
Rpl36	7135	-360	-150	-2665	-103
Rpl36a	5904	3851	-7112	-3075	888
Rpl36al	6602	1722	-4535	-3169	-3710
Rpl37	6386	2813	136	-3794	2629
Rpl37a	6864	5936	-2841	-5378	2168
Rpl38	7298	3812	1185	-5901	2995
Rpl39	7598	4654	-2511	-589	-692
Rpl4	5756	5894	-5753	1571	-2603
Rpl5	5400	5787	-7519	-6710	4137
Rpl6	4275	6481	-6487	-1115	-2121
Rpl7	5698	4796	-6121	1553	-4299
Rpl7a	4025	2177	-4014	2020	-2083
Rpl8	6941	2545	-2412	-2515	439
Rpl9	6698	4914	-6268	1210	-367
Rplp0	5928	5641	-7544	-1113	-209
Rplp1	7127	-527	-2470	-3082	2324
Rplp2	7151	736	-393	-3099	909
Rpn1	3184	2471	-3848	5560	206
Rpn2	5172	3113	-226	1701	5263
Rps10	6734	1046	-3966	-573	-738
Rps11	5426	3353	-4159	-1916	-9
Rps12	6718	-503	-1668	-1219	3087
Rps13	6658	2050	-5585	-3255	2044
Rps14	6674	-1346	-5674	-3046	2038
Rps15	6537	648	-2023	-3381	1025
Rps15a	6000	-349	-3092	2262	-573
Rps16	6662	1809	-4772	-5150	-316
Rps17	6230	2600	-3525	-1304	-95
Rps18	4186	5259	-7830	1770	-2583
Rps19	7297	5099	-4363	-3136	469
Rps2	1985	1347	-7253	-3792	-2992
Rps20	7420	5188	-4681	-3203	279
Rps21	7550	3041	-1313	-2613	1590
Rps23	6624	6539	-6055	-4253	2977
Rps24	6709	6133	-7080	-610	-3725
Rps25	5861	7567	-5278	-2170	-1110
Rps26	5293	5006	-3542	-3078	353
Rps27	7346	2096	-3334	-2880	790
Rps27a	7082	6031	-6010	-1860	-1558
Rps27l	6486	7192	-5515	-556	-524
Rps28	7316	3712	2215	-5643	3290
Rps29	7693	5551	3677	-6437	6008
Rps3	7020	1312	-6127	3720	897
Rps3a1	6918	6811	-6743	1311	-4093
Rps4x	6043	6449	-6599	-736	-3790
Rps5	6901	4728	-2795	-1891	990
Rps6	6942	1947	-6281	2698	-2541
Rps7	3049	6045	-7818	-720	-2250
Rps8	6897	7067	-6092	-3418	2668
Rps9	7030	7339	-4933	-3399	2224
Rpsa	7237	2968	-4190	-1680	1042
Sars	-7520	102	-6686	1264	-3622
Sars2	-3203	1232	5772	-172	4630
Sec11a	2811	777	-5918	4142	3313
Sec11c	5062	6540	-4788	-1445	-4514
Sec61a1	471	-5147	6812	-1055	6420
Sec61a2	-5128	-5804	1625	2248	2525
Sec61b	7050	1998	-2692	-267	3842
Sec61g	7494	3078	-6252	1216	-3194
Spcs1	7109	7676	-6134	-1457	-3637
Spcs2	4596	5236	-7758	-940	-1235
Spcs3	-951	5788	-7226	8019	-4668
Srp14	2491	3654	-6225	-2175	-1930
Srp19	5501	3923	-7095	-2046	-5228
Srp54a	2371	6778	-7362	-583	-3685
Srp68	146	-924	5594	8778	5107
Srp72	-1720	6982	-2498	1967	18
Srp9	3903	5403	-5598	1841	-5695
Srpr	57	6314	2482	7734	-275
Srprb	-3533	5223	123	4088	5975
Ssr1	-1009	4811	-6664	3822	-2278
Ssr2	4505	3866	-2249	4459	-1372
Ssr3	7259	7301	-6806	7907	-4381
Ssr4	6056	-77	-2472	-2166	869
Tars	-2272	3355	234	-785	-6287
Tars2	3355	-4639	2440	-2506	700
Tram1	6286	2414	-2960	6419	-2139
Trmt112	2648	-1538	-5541	-6493	4485
Tsfm	2542	1880	-5037	-5904	-766
Tufm	4156	3964	1136	-2236	539
Uba52	6848	4468	-3633	-6717	4906
Vars	3361	-6443	5931	-5549	4944
Vars2	1930	-6608	7198	4431	5195
Wars	-3581	841	4109	6358	-78
Wars2	-3885	-84	3871	5156	424
Yars	-4295	5759	-2797	4577	-3050
Yars2	5778	-589	-2950	7474	-2481

---

---

AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA

AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA

metric	value
setSize	53
pMANOVA	7.21e-10
p.adjustMANOVA	1.81e-08
s.dist	0.73
s.hyp	0.366
s.amy	0.357
s.hip	-0.434
s.pag	-0.0854
s.ni	-0.274
p.hyp	4.08e-06
p.amy	6.78e-06
p.hip	4.6e-08
p.pag	0.283
p.ni	0.000556

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	hyp
Psma3	-7489	6690
Psme2	-6094	7552
Psmd14	-7045	6264
Psmd10	-6730	6335
Rps27a	-6010	7082
Psmb7	-6836	5789
Psmb1	-7081	5425
Pabpc1	-6820	5166
Psma1	-6202	5607
Psmd7	-6186	5456
Psmd8	-5941	5672
Psmd6	-6924	4799
Psma6	-7561	4242
Psma2	-6869	4297
Psmc5	-4266	6184
Uba52	-3633	6848
Psma5	-6617	3323
Psmb4	-3788	5774
Psma7	-4973	4349
Psmb8	-6298	3419

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Eif4g1	-2094	-6038	3643	39	6315
Hnrnpd	-1177	1712	-6810	-6148	2491
Hspa1a	-7590	-4974	921	-6132	-3824
Hspa8	-4013	5112	-7401	953	-5665
Hspb1	7378	5383	4527	1946	-2753
Pabpc1	5166	6209	-6820	-150	1038
Psma1	5607	5571	-6202	4742	-6763
Psma2	4297	5066	-6869	4103	-6534
Psma3	6690	6047	-7489	-1552	-2237
Psma4	1746	4585	-6654	-1796	-5553
Psma5	3323	-1473	-6617	3568	-4793
Psma6	4242	5431	-7561	5365	-5733
Psma7	4349	2254	-4973	-1616	-2289
Psmb1	5425	6833	-7081	1876	-5399
Psmb10	5365	-1177	-2384	-3876	1032
Psmb2	6874	4672	1134	-1064	290
Psmb3	5156	749	-798	-1635	-2799
Psmb4	5774	5078	-3788	-2700	2441
Psmb5	5739	552	3826	-5060	1805
Psmb6	5243	-395	-1575	-982	-213
Psmb7	5789	3930	-6836	521	-5745
Psmb8	3419	2737	-6298	-2899	3478
Psmb9	840	-4742	-2793	-4571	167
Psmc1	1283	7563	-7755	-3571	-2837
Psmc2	399	6671	-6314	1438	-4043
Psmc3	5783	1161	-2887	2024	-4416
Psmc4	5458	8	2121	456	273
Psmc5	6184	5195	-4266	1972	-5212
Psmc6	-4950	6648	-7434	8559	-7419
Psmd1	-1911	7525	-6549	-2341	-251
Psmd10	6335	1117	-6730	3842	-5683
Psmd11	770	979	600	-3451	-1053
Psmd12	-7349	6212	-7689	6526	-7219
Psmd13	6487	-1504	-1320	4366	-2360
Psmd14	6264	5293	-7045	6717	-6868
Psmd2	-866	-163	-93	7544	1305
Psmd3	6427	-50	6650	4129	3084
Psmd4	3270	646	1379	-3445	2190
Psmd5	-1202	4465	-2978	7366	-2873
Psmd6	4799	5502	-6924	6782	-5318
Psmd7	5456	5674	-6186	-2000	2853
Psmd8	5672	7148	-5941	527	-6056
Psmd9	6231	3555	169	-2328	6272
Psme1	4251	89	-2892	-1727	7025
Psme2	7552	1605	-6094	-5627	-1591
Psme3	3041	4955	-3094	1531	-1448
Psme4	-2266	-7768	3279	1953	-3258
Psmf1	-357	3225	355	-1462	-3411
Rps27a	7082	6031	-6010	-1860	-1558
Sem1	6677	1611	-3004	-2721	-2140
Uba52	6848	4468	-3633	-6717	4906
Ubb	78	4259	-1569	-1900	-1839
Ubc	-6659	-637	164	5564	729

---

---

PHASE 2 PLATEAU PHASE

PHASE 2 PLATEAU PHASE

metric	value
setSize	10
pMANOVA	0.0253
p.adjustMANOVA	0.0654
s.dist	0.726
s.hyp	-0.163
s.amy	-0.0954
s.hip	0.397
s.pag	-0.0682
s.ni	0.574
p.hyp	0.373
p.amy	0.601
p.hip	0.0299
p.pag	0.709
p.ni	0.00166

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	ni	hip
Cacng8	7514	7555
Cacna1c	6274	6743
Cacnb1	6149	6230
Cacng4	8307	2978
Akap9	7367	2317
Cacng7	2543	5543
Cacna2d2	3049	4154
Cacnb2	308	3778

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Akap9	-1070	-5047	2317	665	7367
Cacna1c	249	-7362	6743	976	6274
Cacna2d2	-2410	565	4154	-2289	3049
Cacnb1	-6452	-1073	6230	1399	6149
Cacnb2	-6295	-2255	3778	437	308
Cacng4	-2370	5657	2978	-5983	8307
Cacng7	-6542	-2392	5543	1266	2543
Cacng8	-2088	-6810	7555	-5943	7514
Kcne1l	7132	7698	-4205	6937	952
Kcne4	7919	2497	-2696	6718	7841

---

---

DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS

DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS

metric	value
setSize	58
pMANOVA	3.17e-10
p.adjustMANOVA	8.91e-09
s.dist	0.717
s.hyp	0.35
s.amy	0.389
s.hip	-0.443
s.pag	0.0486
s.ni	-0.204
p.hyp	4.15e-06
p.amy	3.06e-07
p.hip	5.39e-09
p.pag	0.522
p.ni	0.0072

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).

Top 20 genes

Gene	hip	amy
Psmc1	-7755	7563
Psmc6	-7434	6648
Psmd1	-6549	7525
Psmb1	-7081	6833
Psmd12	-7689	6212
Erlec1	-7595	5980
Psma3	-7489	6047
Psmd8	-5941	7148
Psmc2	-6314	6671
Psma6	-7561	5431
Vcp	-5896	6851
Psmd6	-6924	5502
Psmd14	-7045	5293
Rps27a	-6010	6031
Psmd7	-6186	5674
Psma2	-6869	5066
Psma1	-6202	5571
Psma4	-6654	4585
Psmb7	-6836	3930
Rnf5	-6003	4472

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Derl1	3937	3711	-4096	7989	1876
Derl2	7720	880	-7331	8760	155
Derl3	-2740	5324	-1251	7759	2397
Erlec1	4852	5980	-7595	2785	-5643
Erlin1	-1807	-2923	-2374	2850	598
Erlin2	-3883	1580	2794	3978	6779
Os9	2978	-179	-1626	7305	7490
Psma1	5607	5571	-6202	4742	-6763
Psma2	4297	5066	-6869	4103	-6534
Psma3	6690	6047	-7489	-1552	-2237
Psma4	1746	4585	-6654	-1796	-5553
Psma5	3323	-1473	-6617	3568	-4793
Psma6	4242	5431	-7561	5365	-5733
Psma7	4349	2254	-4973	-1616	-2289
Psmb1	5425	6833	-7081	1876	-5399
Psmb10	5365	-1177	-2384	-3876	1032
Psmb2	6874	4672	1134	-1064	290
Psmb3	5156	749	-798	-1635	-2799
Psmb4	5774	5078	-3788	-2700	2441
Psmb5	5739	552	3826	-5060	1805
Psmb6	5243	-395	-1575	-982	-213
Psmb7	5789	3930	-6836	521	-5745
Psmb8	3419	2737	-6298	-2899	3478
Psmb9	840	-4742	-2793	-4571	167
Psmc1	1283	7563	-7755	-3571	-2837
Psmc2	399	6671	-6314	1438	-4043
Psmc3	5783	1161	-2887	2024	-4416
Psmc4	5458	8	2121	456	273
Psmc5	6184	5195	-4266	1972	-5212
Psmc6	-4950	6648	-7434	8559	-7419
Psmd1	-1911	7525	-6549	-2341	-251
Psmd10	6335	1117	-6730	3842	-5683
Psmd11	770	979	600	-3451	-1053
Psmd12	-7349	6212	-7689	6526	-7219
Psmd13	6487	-1504	-1320	4366	-2360
Psmd14	6264	5293	-7045	6717	-6868
Psmd2	-866	-163	-93	7544	1305
Psmd3	6427	-50	6650	4129	3084
Psmd4	3270	646	1379	-3445	2190
Psmd5	-1202	4465	-2978	7366	-2873
Psmd6	4799	5502	-6924	6782	-5318
Psmd7	5456	5674	-6186	-2000	2853
Psmd8	5672	7148	-5941	527	-6056
Psmd9	6231	3555	169	-2328	6272
Psme1	4251	89	-2892	-1727	7025
Psme2	7552	1605	-6094	-5627	-1591
Psme3	3041	4955	-3094	1531	-1448
Psme4	-2266	-7768	3279	1953	-3258
Psmf1	-357	3225	355	-1462	-3411
Rnf185	-7246	5647	-1629	1979	1047
Rnf5	635	4472	-6003	961	884
Rps27a	7082	6031	-6010	-1860	-1558
Sel1l	-1930	3978	2404	4756	2776
Sem1	6677	1611	-3004	-2721	-2140
Uba52	6848	4468	-3633	-6717	4906
Ubb	78	4259	-1569	-1900	-1839
Ubc	-6659	-637	164	5564	729
Vcp	2537	6851	-5896	4206	2964

---

---

APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION

metric	value
setSize	10
pMANOVA	0.0317
p.adjustMANOVA	0.0779
s.dist	0.717
s.hyp	-0.236
s.amy	0.00957
s.hip	-0.477
s.pag	-0.29
s.ni	-0.383
p.hyp	0.196
p.amy	0.958
p.hip	0.00907
p.pag	0.113
p.ni	0.0361

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
H1f0	-7651	-6885
Hmgb1	-7700	-5136
Kpna1	-5020	-6058
H1f2	-7814	-3540
Hmgb2	-7361	-3451
Casp3	-7733	-1153

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Casp3	-1292	-577	-7733	1746	-1153
Dffa	-5802	-6007	5518	-2596	-3085
Dffb	-4130	-6159	5234	-4442	-3245
H1f0	-7810	-5611	-7651	-6456	-6885
H1f2	-2594	1081	-7814	-6214	-3540
H1f4	-2341	3955	-5361	3557	3102
Hmgb1	5406	6615	-7700	-3482	-5136
Hmgb2	2991	-3473	-7361	-5029	-3451
Kpna1	1021	7523	-5020	4281	-6058
Kpnb1	-3210	2451	1110	5261	3920

---

---

INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS

metric	value
setSize	27
pMANOVA	0.00032
p.adjustMANOVA	0.00185
s.dist	0.712
s.hyp	-0.291
s.amy	-0.348
s.hip	0.395
s.pag	-0.12
s.ni	0.362
p.hyp	0.00879
p.amy	0.00173
p.hip	0.000387
p.pag	0.28
p.ni	0.00114

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hip	ni
Sptbn4	7720	7347
Scn3b	7505	6791
Nfasc	7645	6508
Kcnq2	7022	6355
Ank2	6884	6391
Scn3a	5566	6624
Sptbn2	6447	5633
Scn5a	4361	7548
Sptb	6669	3958
Scn2b	3557	7185
Kcnq3	4391	5730
Sptbn1	3549	6934
Sptan1	5427	4449
L1cam	5153	4544
Scn8a	7243	797
Ank3	3364	1573
Scn2a	522	4031
Ank1	2997	267
Nrcam	1355	454

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Actb	429	1897	-1069	-6722	1629
Actg1	-5452	5419	-5547	-2670	-4370
Ank1	-2333	-4030	2997	2822	267
Ank2	-210	-7907	6884	-86	6391
Ank3	-127	539	3364	-4773	1573
Kcnq2	-4331	-4991	7022	2634	6355
Kcnq3	-1348	-1939	4391	-4617	5730
L1cam	-6004	-6352	5153	2277	4544
Nfasc	-4993	-4390	7645	287	6508
Nrcam	-5072	-6030	1355	6423	454
Scn1a	-2202	-678	-77	4426	-4828
Scn1b	-5892	540	1197	-1381	-5084
Scn2a	-1853	-4879	522	-4259	4031
Scn2b	-3368	-3792	3557	-2255	7185
Scn3a	-812	-2340	5566	-4732	6624
Scn3b	-7017	-3150	7505	81	6791
Scn4b	-3483	3215	1529	1527	-4127
Scn5a	-4370	-1963	4361	-4740	7548
Scn7a	4002	-549	-3450	1632	4464
Scn8a	-3255	-7042	7243	-4929	797
Scn9a	5423	-6267	-505	-6022	2257
Sptan1	-4420	-6818	5427	6264	4449
Sptb	-5041	717	6669	5418	3958
Sptbn1	35	-4657	3549	5270	6934
Sptbn2	-2265	-1447	6447	5449	5633
Sptbn4	-489	-5718	7720	1386	7347
Sptbn5	4773	-4449	-2485	1528	7200

---

---

ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS

ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS

metric	value
setSize	10
pMANOVA	0.0138
p.adjustMANOVA	0.0405
s.dist	0.709
s.hyp	-0.554
s.amy	-0.246
s.hip	-0.0696
s.pag	0.155
s.ni	-0.327
p.hyp	0.00243
p.amy	0.177
p.hip	0.703
p.pag	0.395
p.ni	0.0735

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	ni
Fos	-7379	-5508
Mapk8	-6996	-4960
Atf2	-5853	-4107
Mapk9	-5421	-3635
Mapk1	-2284	-4085
Mapk10	-5817	-568
Mapk11	-4486	-637
Jun	-7115	-136

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Atf2	-5853	1618	-5009	8379	-4107
Fos	-7379	-4898	-4346	-5897	-5508
Jun	-7115	-4866	3199	-502	-136
Mapk1	-2284	2893	-1870	7598	-4085
Mapk10	-5817	-4652	668	-881	-568
Mapk11	-4486	-7856	4618	-5481	-637
Mapk14	-1533	-3849	7117	1818	4058
Mapk3	3966	1325	-786	4861	-1529
Mapk8	-6996	-5161	-5272	5645	-4960
Mapk9	-5421	4958	-2853	6355	-3635

---

---

SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX

SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX

metric	value
setSize	13
pMANOVA	0.0107
p.adjustMANOVA	0.0331
s.dist	0.707
s.hyp	0.477
s.amy	0.423
s.hip	-0.3
s.pag	-0.00586
s.ni	0.0574
p.hyp	0.00291
p.amy	0.00823
p.hip	0.0614
p.pag	0.971
p.ni	0.72

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	hyp	amy
Ptgds	7544	7677
Ptgis	7918	5826
Ptges3	6900	5578
Hpgd	7486	4700
Prxl2b	7403	4092
Ptgr2	1978	6246
Ptges	2269	4502
Hpgds	1937	4568
Ptges2	6631	1199
Tbxas1	7843	510
Ptgs1	144	5145

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Cbr1	-35	-3931	819	791	2413
Hpgd	7486	4700	-2015	1517	-6147
Hpgds	1937	4568	-1531	5124	-578
Prxl2b	7403	4092	-3339	-3316	425
Ptgds	7544	7677	1087	8390	1533
Ptges	2269	4502	-2029	-5869	6264
Ptges2	6631	1199	-2188	1827	4481
Ptges3	6900	5578	-7454	-4578	-4756
Ptgis	7918	5826	2072	5675	6565
Ptgr2	1978	6246	-6387	646	2042
Ptgs1	144	5145	-4255	5980	4091
Ptgs2	-7661	-3769	-2730	-4288	-597
Tbxas1	7843	510	-1640	-36	-3599

---

---

GLYCOGEN SYNTHESIS

GLYCOGEN SYNTHESIS

metric	value
setSize	14
pMANOVA	0.0176
p.adjustMANOVA	0.0494
s.dist	0.707
s.hyp	0.198
s.amy	0.462
s.hip	-0.422
s.pag	0.234
s.ni	-0.116
p.hyp	0.199
p.amy	0.00277
p.hip	0.00621
p.pag	0.13
p.ni	0.451

Warning: Removed 396 rows containing missing values or values outside the scale range (`geom_tile()`).
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Top 20 genes

Gene	amy	hip
Ugp2	7316	-7791
Gyg	7000	-6333
Ppp1r3c	4767	-7788
Rps27a	6031	-6010
Gbe1	7165	-3043
Pgm1	7832	-2382
Uba52	4468	-3633
Ubb	4259	-1569
Pgm2	686	-5186

Click HERE to show all gene set members

All member genes

	hyp	amy	hip	pag	ni
Epm2a	-4828	-6241	-3201	6463	5645
Gbe1	2120	7165	-3043	8307	-4175
Gyg	1851	7000	-6333	2214	-5270
Gys1	2517	2949	6798	7471	2897
Nhlrc1	-2218	4804	134	115	6415
Pgm1	7862	7832	-2382	8616	7191
Pgm2	276	686	-5186	1100	-5274
Pgm2l1	-1864	-522	-5631	-1592	-3164
Ppp1r3c	5104	4767	-7788	3045	-5381
Rps27a	7082	6031	-6010	-1860	-1558
Uba52	6848	4468	-3633	-6717	4906
Ubb	78	4259	-1569	-1900	-1839
Ubc	-6659	-637	164	5564	729
Ugp2	5165	7316	-7791	8533	-7310

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.2.1                ggplot2_3.5.1              
##  [3] gtools_3.9.5                tibble_3.2.1               
##  [5] dplyr_1.1.4                 echarts4r_0.4.5            
##  [7] beeswarm_0.4.0              pkgload_1.3.4              
##  [9] vioplot_0.4.0               sm_2.2-6.0                 
## [11] kableExtra_1.4.0            topconfects_1.20.0         
## [13] limma_3.60.0                eulerr_7.0.2               
## [15] mitch_1.16.0                MASS_7.3-60.2              
## [17] fgsea_1.30.0                gplots_3.1.3.1             
## [19] DESeq2_1.44.0               SummarizedExperiment_1.34.0
## [21] Biobase_2.64.0              MatrixGenerics_1.16.0      
## [23] matrixStats_1.3.0           GenomicRanges_1.56.0       
## [25] GenomeInfoDb_1.40.0         IRanges_2.38.0             
## [27] S4Vectors_0.42.0            BiocGenerics_0.50.0        
## [29] reshape2_1.4.4              zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.3            
##  [4] magrittr_2.0.3          compiler_4.4.0          polylabelr_0.2.0       
##  [7] systemfonts_1.1.0       vctrs_0.6.5             stringr_1.5.1          
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.2.0          
## [13] XVector_0.44.0          labeling_0.4.3          caTools_1.18.2         
## [16] utf8_1.2.4              promises_1.3.0          rmarkdown_2.27         
## [19] UCSC.utils_1.0.0        purrr_1.0.2             xfun_0.44              
## [22] zlibbioc_1.50.0         cachem_1.1.0            jsonlite_1.8.8         
## [25] progress_1.2.3          highr_0.11              later_1.3.2            
## [28] DelayedArray_0.30.1     BiocParallel_1.38.0     prettyunits_1.2.0      
## [31] parallel_4.4.0          R6_2.5.1                bslib_0.7.0            
## [34] stringi_1.8.4           RColorBrewer_1.1-3      jquerylib_0.1.4        
## [37] Rcpp_1.0.12             assertthat_0.2.1        knitr_1.47             
## [40] httpuv_1.6.15           Matrix_1.7-0            tidyselect_1.2.1       
## [43] rstudioapi_0.16.0       abind_1.4-5             yaml_2.3.8             
## [46] codetools_0.2-20        lattice_0.22-6          plyr_1.8.9             
## [49] withr_3.0.0             shiny_1.8.1.1           evaluate_0.23          
## [52] polyclip_1.10-6         ggstats_0.6.0           xml2_1.3.6             
## [55] pillar_1.9.0            KernSmooth_2.23-24      generics_0.1.3         
## [58] hms_1.1.3               munsell_0.5.1           scales_1.3.0           
## [61] xtable_1.8-4            glue_1.7.0              tools_4.4.0            
## [64] data.table_1.15.4       locfit_1.5-9.9          fastmatch_1.1-4        
## [67] cowplot_1.1.3           grid_4.4.0              tidyr_1.3.1            
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.12 cli_3.6.2              
## [73] fansi_1.0.6             S4Arrays_1.4.0          viridisLite_0.4.2      
## [76] svglite_2.1.3           gtable_0.3.5            sass_0.4.9             
## [79] digest_0.6.35           SparseArray_1.4.3       farver_2.1.2           
## [82] htmlwidgets_1.6.4       htmltools_0.5.8.1       lifecycle_1.0.4        
## [85] httr_1.4.7              statmod_1.5.0           mime_0.12

END of report