date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik -0.3304181 0.0972207
0610009E02Rik 0.7596333 1.2632625
0610009L18Rik -1.2521412 -0.6637497
0610010K14Rik 0.4193627 -0.4536898
0610012G03Rik 1.4462155 0.1223624
0610030E20Rik -0.2426628 -0.0456229

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 16956
duplicated_genes_present 0
num_profile_genes_in_sets 8348
num_profile_genes_not_in_sets 8608
profile_pearson_correl 0.42385
profile_spearman_correl 0.40706

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 429
num_genesets_included 1175

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 205

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.51e-33 2.06e-30 0.814 0.3000 0.75700 1.29e-06 2.29e-34
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.39e-32 9.37e-30 0.723 0.2540 0.67700 6.28e-06 1.71e-33
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 3.39e-27 7.97e-25 0.690 0.2220 0.65300 1.83e-04 3.37e-28
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 2.92e-03 2.11e-02 0.676 -0.2600 -0.62400 1.55e-01 6.34e-04
EUKARYOTIC TRANSLATION INITIATION 114 1.96e-30 5.75e-28 0.663 0.2040 0.63100 1.65e-04 2.33e-31
REDUCTION OF CYTOSOLIC CA LEVELS 11 4.75e-03 3.08e-02 0.650 -0.5570 -0.33600 1.38e-03 5.39e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.52e-03 1.27e-02 0.633 0.1440 0.61600 4.08e-01 4.01e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.34e-06 1.31e-04 0.629 0.6290 -0.00378 7.13e-06 9.78e-01
SELENOAMINO ACID METABOLISM 109 1.38e-24 2.31e-22 0.629 0.2410 0.58100 1.43e-05 1.04e-25
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 6.43e-05 1.01e-03 0.614 0.5810 0.19900 1.17e-05 1.33e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.25e-14 2.55e-12 0.609 0.1620 0.58700 3.15e-02 6.12e-15
CGMP EFFECTS 15 8.04e-04 8.01e-03 0.604 -0.5630 -0.22000 1.60e-04 1.41e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 7.84e-04 7.87e-03 0.604 0.5920 0.12200 2.21e-04 4.48e-01
P75NTR REGULATES AXONOGENESIS 10 1.97e-02 9.16e-02 0.592 -0.4920 -0.33000 7.10e-03 7.10e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.05e-02 5.83e-02 0.587 -0.2020 -0.55100 2.69e-01 2.55e-03
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 2.48e-02 1.07e-01 0.586 -0.3760 -0.45000 3.97e-02 1.38e-02
HDR THROUGH MMEJ ALT NHEJ 10 2.87e-02 1.19e-01 0.572 -0.3550 -0.44900 5.20e-02 1.40e-02
ENDOSOMAL VACUOLAR PATHWAY 11 1.93e-04 2.42e-03 0.567 -0.2760 0.49500 1.13e-01 4.45e-03
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 8.65e-03 4.96e-02 0.564 -0.2340 -0.51300 1.60e-01 2.09e-03
NONSENSE MEDIATED DECAY NMD 109 1.75e-20 2.28e-18 0.564 0.1970 0.52800 3.79e-04 1.54e-21
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.62e-04 3.08e-03 0.557 0.1250 0.54300 3.59e-01 6.69e-05
COMPLEX I BIOGENESIS 56 1.10e-10 6.43e-09 0.556 0.1910 0.52300 1.33e-02 1.32e-11
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.36e-04 3.83e-03 0.553 -0.5160 -0.19800 6.38e-05 1.25e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 5.77e-06 1.38e-04 0.538 -0.3990 -0.36100 1.59e-05 9.68e-05
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.34e-02 1.33e-01 0.529 -0.4740 -0.23500 9.46e-03 1.98e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 8.38e-07 3.04e-05 0.529 0.3240 0.41800 1.45e-04 9.20e-07
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 9.62e-04 9.06e-03 0.528 -0.1550 -0.50400 2.55e-01 2.11e-04
KERATAN SULFATE DEGRADATION 12 2.81e-02 1.17e-01 0.524 0.3260 0.41000 5.03e-02 1.39e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.56e-05 1.14e-03 0.523 0.5120 0.10400 2.12e-05 3.88e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 4.30e-24 6.32e-22 0.521 0.2160 0.47400 2.45e-06 3.81e-25
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 1.86e-02 8.73e-02 0.505 -0.0816 -0.49800 6.55e-01 6.37e-03
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 1.86e-02 8.73e-02 0.505 -0.0816 -0.49800 6.55e-01 6.37e-03
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.11e-03 1.00e-02 0.504 -0.2830 -0.41700 1.64e-02 4.06e-04
DSCAM INTERACTIONS 10 5.90e-02 1.95e-01 0.501 -0.2740 -0.42000 1.34e-01 2.16e-02
PHASE 0 RAPID DEPOLARISATION 30 3.55e-04 4.01e-03 0.495 -0.3090 -0.38600 3.45e-03 2.49e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.64e-18 3.11e-16 0.492 0.1600 0.46500 2.01e-03 2.80e-19
TRANSLATION 286 3.61e-34 4.24e-31 0.489 0.2600 0.41400 3.90e-14 1.70e-33
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.34e-06 4.27e-05 0.489 0.3250 0.36500 4.23e-05 4.35e-06
RESPIRATORY ELECTRON TRANSPORT 102 6.77e-15 6.63e-13 0.489 0.1600 0.46200 5.31e-03 7.62e-16
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.90e-02 1.95e-01 0.488 -0.3800 -0.30500 2.90e-02 7.97e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 3.46e-02 1.36e-01 0.487 0.3860 0.29700 1.59e-02 6.37e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 7.95e-02 2.34e-01 0.484 -0.3050 -0.37600 9.53e-02 3.96e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 9.23e-03 5.22e-02 0.483 0.0845 0.47600 5.98e-01 2.99e-03
STABILIZATION OF P53 54 1.49e-06 4.61e-05 0.481 0.3120 0.36600 7.18e-05 3.25e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.38e-02 1.34e-01 0.479 0.2050 0.43300 2.18e-01 9.44e-03
MITOCHONDRIAL TRANSLATION 93 1.37e-10 7.64e-09 0.478 0.3130 0.36200 1.92e-07 1.67e-09
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 8.34e-03 4.88e-02 0.474 0.4710 0.05160 3.26e-03 7.47e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.20e-02 1.78e-01 0.472 -0.1600 -0.44400 3.81e-01 1.51e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 8.94e-08 4.04e-06 0.470 0.3890 0.26400 4.70e-08 2.14e-04
GLUTATHIONE SYNTHESIS AND RECYCLING 11 7.24e-02 2.21e-01 0.468 0.2850 0.37100 1.02e-01 3.30e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
EUKARYOTIC TRANSLATION ELONGATION 87 3.51e-33 2.06e-30 0.81400 3.00e-01 0.757000 1.29e-06 2.29e-34
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.39e-32 9.37e-30 0.72300 2.54e-01 0.677000 6.28e-06 1.71e-33
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 3.39e-27 7.97e-25 0.69000 2.22e-01 0.653000 1.83e-04 3.37e-28
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 2.92e-03 2.11e-02 0.67600 -2.60e-01 -0.624000 1.55e-01 6.34e-04
EUKARYOTIC TRANSLATION INITIATION 114 1.96e-30 5.75e-28 0.66300 2.04e-01 0.631000 1.65e-04 2.33e-31
REDUCTION OF CYTOSOLIC CA LEVELS 11 4.75e-03 3.08e-02 0.65000 -5.57e-01 -0.336000 1.38e-03 5.39e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.52e-03 1.27e-02 0.63300 1.44e-01 0.616000 4.08e-01 4.01e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.34e-06 1.31e-04 0.62900 6.29e-01 -0.003780 7.13e-06 9.78e-01
SELENOAMINO ACID METABOLISM 109 1.38e-24 2.31e-22 0.62900 2.41e-01 0.581000 1.43e-05 1.04e-25
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 6.43e-05 1.01e-03 0.61400 5.81e-01 0.199000 1.17e-05 1.33e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.25e-14 2.55e-12 0.60900 1.62e-01 0.587000 3.15e-02 6.12e-15
CGMP EFFECTS 15 8.04e-04 8.01e-03 0.60400 -5.63e-01 -0.220000 1.60e-04 1.41e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 7.84e-04 7.87e-03 0.60400 5.92e-01 0.122000 2.21e-04 4.48e-01
P75NTR REGULATES AXONOGENESIS 10 1.97e-02 9.16e-02 0.59200 -4.92e-01 -0.330000 7.10e-03 7.10e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.05e-02 5.83e-02 0.58700 -2.02e-01 -0.551000 2.69e-01 2.55e-03
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 2.48e-02 1.07e-01 0.58600 -3.76e-01 -0.450000 3.97e-02 1.38e-02
HDR THROUGH MMEJ ALT NHEJ 10 2.87e-02 1.19e-01 0.57200 -3.55e-01 -0.449000 5.20e-02 1.40e-02
ENDOSOMAL VACUOLAR PATHWAY 11 1.93e-04 2.42e-03 0.56700 -2.76e-01 0.495000 1.13e-01 4.45e-03
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 8.65e-03 4.96e-02 0.56400 -2.34e-01 -0.513000 1.60e-01 2.09e-03
NONSENSE MEDIATED DECAY NMD 109 1.75e-20 2.28e-18 0.56400 1.97e-01 0.528000 3.79e-04 1.54e-21
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.62e-04 3.08e-03 0.55700 1.25e-01 0.543000 3.59e-01 6.69e-05
COMPLEX I BIOGENESIS 56 1.10e-10 6.43e-09 0.55600 1.91e-01 0.523000 1.33e-02 1.32e-11
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.36e-04 3.83e-03 0.55300 -5.16e-01 -0.198000 6.38e-05 1.25e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 5.77e-06 1.38e-04 0.53800 -3.99e-01 -0.361000 1.59e-05 9.68e-05
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.34e-02 1.33e-01 0.52900 -4.74e-01 -0.235000 9.46e-03 1.98e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 8.38e-07 3.04e-05 0.52900 3.24e-01 0.418000 1.45e-04 9.20e-07
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 9.62e-04 9.06e-03 0.52800 -1.55e-01 -0.504000 2.55e-01 2.11e-04
KERATAN SULFATE DEGRADATION 12 2.81e-02 1.17e-01 0.52400 3.26e-01 0.410000 5.03e-02 1.39e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 7.56e-05 1.14e-03 0.52300 5.12e-01 0.104000 2.12e-05 3.88e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 4.30e-24 6.32e-22 0.52100 2.16e-01 0.474000 2.45e-06 3.81e-25
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 1.86e-02 8.73e-02 0.50500 -8.16e-02 -0.498000 6.55e-01 6.37e-03
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 1.86e-02 8.73e-02 0.50500 -8.16e-02 -0.498000 6.55e-01 6.37e-03
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.11e-03 1.00e-02 0.50400 -2.83e-01 -0.417000 1.64e-02 4.06e-04
DSCAM INTERACTIONS 10 5.90e-02 1.95e-01 0.50100 -2.74e-01 -0.420000 1.34e-01 2.16e-02
PHASE 0 RAPID DEPOLARISATION 30 3.55e-04 4.01e-03 0.49500 -3.09e-01 -0.386000 3.45e-03 2.49e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.64e-18 3.11e-16 0.49200 1.60e-01 0.465000 2.01e-03 2.80e-19
TRANSLATION 286 3.61e-34 4.24e-31 0.48900 2.60e-01 0.414000 3.90e-14 1.70e-33
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.34e-06 4.27e-05 0.48900 3.25e-01 0.365000 4.23e-05 4.35e-06
RESPIRATORY ELECTRON TRANSPORT 102 6.77e-15 6.63e-13 0.48900 1.60e-01 0.462000 5.31e-03 7.62e-16
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.90e-02 1.95e-01 0.48800 -3.80e-01 -0.305000 2.90e-02 7.97e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 3.46e-02 1.36e-01 0.48700 3.86e-01 0.297000 1.59e-02 6.37e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 7.95e-02 2.34e-01 0.48400 -3.05e-01 -0.376000 9.53e-02 3.96e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 9.23e-03 5.22e-02 0.48300 8.45e-02 0.476000 5.98e-01 2.99e-03
STABILIZATION OF P53 54 1.49e-06 4.61e-05 0.48100 3.12e-01 0.366000 7.18e-05 3.25e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.38e-02 1.34e-01 0.47900 2.05e-01 0.433000 2.18e-01 9.44e-03
MITOCHONDRIAL TRANSLATION 93 1.37e-10 7.64e-09 0.47800 3.13e-01 0.362000 1.92e-07 1.67e-09
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 8.34e-03 4.88e-02 0.47400 4.71e-01 0.051600 3.26e-03 7.47e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.20e-02 1.78e-01 0.47200 -1.60e-01 -0.444000 3.81e-01 1.51e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 8.94e-08 4.04e-06 0.47000 3.89e-01 0.264000 4.70e-08 2.14e-04
GLUTATHIONE SYNTHESIS AND RECYCLING 11 7.24e-02 2.21e-01 0.46800 2.85e-01 0.371000 1.02e-01 3.30e-02
PHASE 4 RESTING MEMBRANE POTENTIAL 14 2.37e-02 1.03e-01 0.46700 -2.01e-01 -0.421000 1.93e-01 6.37e-03
MATURATION OF NUCLEOPROTEIN 10 9.79e-02 2.64e-01 0.46700 -3.42e-01 -0.317000 6.09e-02 8.26e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.84e-02 1.46e-01 0.46500 -4.43e-01 -0.142000 1.10e-02 4.16e-01
HEDGEHOG LIGAND BIOGENESIS 61 8.71e-07 3.04e-05 0.46300 3.09e-01 0.345000 2.98e-05 3.23e-06
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 6.12e-06 1.43e-04 0.46100 3.22e-01 0.331000 5.13e-05 3.09e-05
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 15 3.31e-02 1.32e-01 0.46000 2.98e-01 0.351000 4.60e-02 1.88e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 1.78e-06 5.35e-05 0.45800 2.99e-01 0.347000 7.08e-05 4.15e-06
RA BIOSYNTHESIS PATHWAY 12 7.01e-02 2.17e-01 0.45600 3.22e-01 0.323000 5.36e-02 5.27e-02
DEGRADATION OF AXIN 53 8.07e-06 1.72e-04 0.45500 3.02e-01 0.341000 1.46e-04 1.78e-05
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 6.71e-06 1.49e-04 0.45300 2.90e-01 0.348000 2.23e-04 9.91e-06
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 1.69e-02 8.32e-02 0.45100 2.55e-01 0.372000 6.14e-02 6.26e-03
CELLULAR RESPONSE TO STARVATION 146 2.52e-17 2.69e-15 0.45100 1.67e-01 0.419000 5.19e-04 2.28e-18
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 2.34e-02 1.02e-01 0.45000 -2.76e-01 -0.356000 4.87e-02 1.11e-02
GLUTATHIONE CONJUGATION 29 1.89e-04 2.40e-03 0.44800 1.01e-01 0.436000 3.44e-01 4.74e-05
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.04e-06 5.83e-05 0.44600 3.13e-01 0.317000 1.97e-05 1.58e-05
GAP JUNCTION ASSEMBLY 21 1.86e-03 1.49e-02 0.44500 4.36e-01 0.088000 5.40e-04 4.85e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 1.36e-04 1.81e-03 0.44500 1.53e-01 0.418000 1.23e-01 2.49e-05
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.57e-03 1.95e-02 0.44400 3.85e-01 0.222000 6.88e-04 4.97e-02
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 5.39e-03 3.39e-02 0.44400 1.76e-01 0.407000 1.62e-01 1.23e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 3.20e-06 8.55e-05 0.44400 2.69e-01 0.353000 3.58e-04 2.73e-06
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 4.79e-04 5.16e-03 0.43900 -1.68e-01 -0.406000 1.05e-01 9.24e-05
GLYCOGEN STORAGE DISEASES 12 4.81e-02 1.69e-01 0.43900 4.10e-01 0.156000 1.38e-02 3.49e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 4.71e-02 1.68e-01 0.43800 1.50e-01 0.412000 3.69e-01 1.35e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 3.18e-02 1.29e-01 0.43800 2.01e-01 0.389000 1.79e-01 9.11e-03
IRE1ALPHA ACTIVATES CHAPERONES 50 2.14e-06 5.86e-05 0.43700 4.16e-01 0.134000 3.63e-07 1.01e-01
ANTIGEN PROCESSING CROSS PRESENTATION 97 2.16e-11 1.34e-09 0.43700 1.48e-01 0.411000 1.20e-02 2.58e-12
METABOLISM OF POLYAMINES 57 6.53e-06 1.48e-04 0.43700 2.57e-01 0.353000 7.88e-04 4.04e-06
DEGRADATION OF DVL 55 1.27e-05 2.53e-04 0.43700 2.79e-01 0.336000 3.42e-04 1.66e-05
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 7.21e-04 7.44e-03 0.43100 -1.40e-01 -0.407000 1.92e-01 1.48e-04
SUMOYLATION OF RNA BINDING PROTEINS 45 6.25e-05 9.93e-04 0.43000 -2.14e-01 -0.373000 1.32e-02 1.49e-05
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.21e-04 8.11e-03 0.42800 -1.92e-01 -0.383000 6.04e-02 1.77e-04
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.74e-03 2.02e-02 0.42400 -3.14e-01 0.285000 4.99e-02 7.56e-02
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 8.64e-03 4.96e-02 0.42300 2.01e-01 -0.373000 2.48e-01 3.24e-02
SUMOYLATION OF SUMOYLATION PROTEINS 33 8.43e-04 8.12e-03 0.42300 -1.95e-01 -0.376000 5.25e-02 1.88e-04
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 5.48e-04 5.81e-03 0.42300 -2.25e-01 -0.358000 1.79e-02 1.66e-04
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 1.04e-01 2.75e-01 0.42200 -2.17e-01 -0.362000 2.13e-01 3.75e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 7.96e-03 4.70e-02 0.42100 -3.71e-01 -0.199000 2.08e-03 9.82e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.46e-01 3.39e-01 0.42000 -3.35e-01 -0.253000 6.64e-02 1.67e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 3.87e-03 2.61e-02 0.41900 8.45e-02 0.410000 5.03e-01 1.13e-03
CS DS DEGRADATION 14 2.86e-02 1.19e-01 0.41500 9.42e-02 0.404000 5.42e-01 8.80e-03
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 1.12e-06 3.66e-05 0.41500 3.97e-01 -0.123000 3.83e-05 2.02e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 3.41e-05 5.81e-04 0.41100 2.69e-01 0.311000 4.55e-04 5.01e-05
CELLULAR RESPONSE TO HYPOXIA 72 8.61e-07 3.04e-05 0.41000 2.09e-01 0.353000 2.12e-03 2.24e-07
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 2.78e-02 1.17e-01 0.40900 3.07e-01 0.270000 1.74e-02 3.66e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 2.21e-05 4.00e-04 0.40800 2.48e-01 0.325000 1.01e-03 1.59e-05
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 5.55e-02 1.88e-01 0.40800 -2.55e-01 -0.319000 7.77e-02 2.71e-02
CRISTAE FORMATION 31 9.84e-04 9.15e-03 0.40700 1.32e-01 0.385000 2.02e-01 2.05e-04
INTRAFLAGELLAR TRANSPORT 51 9.72e-06 2.00e-04 0.40400 3.86e-01 0.117000 1.81e-06 1.48e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 1.60e-05 3.03e-04 0.40300 2.55e-01 0.313000 4.71e-04 1.78e-05
NUCLEAR IMPORT OF REV PROTEIN 32 1.36e-03 1.16e-02 0.40300 -1.56e-01 -0.371000 1.26e-01 2.80e-04
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.61e-02 2.44e-01 0.40200 3.49e-01 0.198000 2.91e-02 2.16e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 7.89e-02 2.34e-01 0.39900 2.79e-01 0.285000 6.18e-02 5.58e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 8.36e-02 2.40e-01 0.39700 -6.18e-02 -0.393000 7.35e-01 3.16e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 9.58e-02 2.60e-01 0.39700 -3.76e-01 -0.128000 3.08e-02 4.63e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 1.83e-01 3.92e-01 0.39700 -2.52e-01 -0.306000 1.67e-01 9.34e-02
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 11 9.08e-02 2.53e-01 0.39700 1.17e-01 0.379000 5.03e-01 2.94e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 3.14e-02 1.28e-01 0.39600 -1.46e-01 -0.369000 2.98e-01 8.51e-03
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.51e-02 2.60e-01 0.39600 -2.98e-01 -0.261000 5.36e-02 9.09e-02
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 1.09e-03 9.97e-03 0.39500 -1.50e-01 -0.366000 1.31e-01 2.22e-04
AGGREPHAGY 35 7.07e-05 1.08e-03 0.39500 3.94e-01 0.011000 5.39e-05 9.10e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 14 6.60e-02 2.08e-01 0.39400 -1.60e-01 -0.360000 2.99e-01 1.98e-02
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 40 1.35e-03 1.16e-02 0.39300 2.60e-01 0.295000 4.50e-03 1.25e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.02e-05 2.06e-04 0.39200 2.63e-01 0.292000 1.45e-04 2.47e-05
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 6.55e-02 2.07e-01 0.39100 3.60e-01 0.153000 1.96e-02 3.22e-01
G PROTEIN ACTIVATION 22 3.35e-03 2.35e-02 0.39100 2.76e-02 0.390000 8.23e-01 1.53e-03
SODIUM CALCIUM EXCHANGERS 10 1.01e-01 2.70e-01 0.39000 -3.82e-01 -0.079400 3.65e-02 6.64e-01
LGI ADAM INTERACTIONS 14 4.95e-02 1.73e-01 0.38900 -1.05e-01 -0.375000 4.98e-01 1.52e-02
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.07e-02 5.93e-02 0.38800 -1.39e-01 -0.363000 2.49e-01 2.60e-03
METABOLISM OF AMINO ACIDS AND DERIVATIVES 315 6.39e-25 1.25e-22 0.38700 1.78e-01 0.344000 5.85e-08 1.09e-25
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 3.84e-03 2.61e-02 0.38700 2.77e-02 0.386000 8.22e-01 1.74e-03
INFLUENZA INFECTION 145 3.43e-13 2.37e-11 0.38200 1.18e-01 0.363000 1.46e-02 4.51e-14
RRNA PROCESSING 194 2.25e-14 1.89e-12 0.38000 2.04e-01 0.320000 9.33e-07 1.54e-14
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 33 7.40e-04 7.56e-03 0.37900 7.25e-02 0.372000 4.71e-01 2.17e-04
MITOCHONDRIAL PROTEIN IMPORT 63 6.62e-05 1.02e-03 0.37900 2.58e-01 0.277000 3.94e-04 1.43e-04
G1 S DNA DAMAGE CHECKPOINTS 65 4.52e-05 7.46e-04 0.37800 2.39e-01 0.293000 8.59e-04 4.48e-05
SIGNALING BY FGFR4 IN DISEASE 10 9.94e-02 2.67e-01 0.37700 -3.74e-01 -0.044800 4.04e-02 8.06e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 1.73e-03 1.41e-02 0.37700 -1.44e-01 -0.348000 1.42e-01 3.62e-04
CYTOSOLIC TRNA AMINOACYLATION 24 4.60e-04 5.05e-03 0.37500 3.52e-01 -0.131000 2.87e-03 2.66e-01
DISEASES OF CARBOHYDRATE METABOLISM 28 9.05e-03 5.16e-02 0.37400 3.33e-01 0.171000 2.32e-03 1.17e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 1.41e-01 3.32e-01 0.37400 -2.37e-01 -0.289000 1.39e-01 7.09e-02
RETINOID CYCLE DISEASE EVENTS 10 1.45e-01 3.39e-01 0.37400 1.11e-01 0.357000 5.43e-01 5.06e-02
INTERLEUKIN 6 SIGNALING 10 2.14e-01 4.36e-01 0.37300 2.17e-01 0.304000 2.35e-01 9.61e-02
KERATAN SULFATE KERATIN METABOLISM 30 8.15e-03 4.79e-02 0.37300 3.20e-01 0.192000 2.41e-03 6.87e-02
PCP CE PATHWAY 89 2.08e-06 5.83e-05 0.37200 2.72e-01 0.253000 9.03e-06 3.67e-05
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 6.21e-06 1.43e-04 0.37100 2.38e-01 0.285000 2.12e-04 9.32e-06
ACTIVATION OF MATRIX METALLOPROTEINASES 14 7.46e-02 2.24e-01 0.37000 -1.18e-01 -0.351000 4.43e-01 2.31e-02
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.06e-04 3.56e-03 0.36900 -9.01e-02 -0.358000 3.18e-01 7.30e-05
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 4.51e-02 1.62e-01 0.36900 -2.90e-01 -0.228000 2.16e-02 7.00e-02
MET ACTIVATES RAP1 AND RAC1 10 9.49e-02 2.60e-01 0.36900 -3.68e-01 -0.016300 4.37e-02 9.29e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 20 1.31e-02 6.92e-02 0.36800 4.92e-02 0.364000 7.03e-01 4.78e-03
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.44e-04 1.90e-03 0.36800 -3.67e-01 0.006250 1.36e-04 9.48e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 1.85e-01 3.95e-01 0.36500 1.90e-01 0.312000 2.76e-01 7.29e-02
KERATAN SULFATE BIOSYNTHESIS 24 2.20e-02 9.91e-02 0.36400 3.24e-01 0.166000 6.08e-03 1.58e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.17e-01 4.39e-01 0.36300 1.84e-01 0.313000 3.13e-01 8.66e-02
POTASSIUM CHANNELS 90 3.74e-06 9.76e-05 0.36200 -2.51e-01 -0.261000 3.96e-05 1.93e-05
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 2.48e-02 1.07e-01 0.36200 3.35e-01 0.136000 6.54e-03 2.68e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 1.02e-04 1.49e-03 0.36100 2.34e-01 0.274000 1.02e-03 1.16e-04
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 2.95e-03 2.11e-02 0.36000 -1.58e-01 -0.323000 9.66e-02 6.73e-04
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 6.03e-02 1.98e-01 0.35900 -2.21e-01 -0.283000 8.67e-02 2.83e-02
INTERACTION BETWEEN L1 AND ANKYRINS 28 2.12e-02 9.68e-02 0.35700 -2.27e-01 -0.276000 3.74e-02 1.16e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 6.80e-02 2.12e-01 0.35700 -2.93e-01 -0.203000 2.70e-02 1.25e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 2.18e-01 4.39e-01 0.35700 -2.83e-01 -0.217000 1.04e-01 2.12e-01
REGULATION OF RAS BY GAPS 66 1.03e-04 1.49e-03 0.35600 2.10e-01 0.287000 3.13e-03 5.41e-05
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 58 2.34e-04 2.86e-03 0.35600 -1.87e-01 -0.302000 1.37e-02 6.80e-05
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 1.03e-01 2.73e-01 0.35500 1.32e-01 0.329000 3.94e-01 3.29e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 48 4.45e-06 1.14e-04 0.35400 -6.22e-02 0.349000 4.56e-01 2.93e-05
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 7.12e-02 2.19e-01 0.35300 -3.40e-01 -0.096900 2.27e-02 5.16e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 3.83e-02 1.46e-01 0.35300 -3.53e-01 -0.012700 1.79e-02 9.32e-01
PREGNENOLONE BIOSYNTHESIS 12 1.78e-01 3.88e-01 0.35300 3.03e-01 0.181000 6.90e-02 2.78e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 1.41e-02 7.37e-02 0.35200 -2.00e-01 -0.290000 5.46e-02 5.26e-03
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.99e-13 1.46e-11 0.35100 1.03e-01 0.336000 2.04e-02 2.93e-14
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 5.06e-03 3.25e-02 0.35100 -1.40e-01 -0.322000 1.58e-01 1.15e-03
COHESIN LOADING ONTO CHROMATIN 10 8.81e-02 2.48e-01 0.35000 -3.47e-01 0.045500 5.75e-02 8.03e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 4.42e-02 1.62e-01 0.34900 3.37e-01 0.092500 1.34e-02 4.97e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 12 4.23e-02 1.58e-01 0.34700 -9.64e-02 0.333000 5.63e-01 4.55e-02
ABC TRANSPORTER DISORDERS 70 1.02e-04 1.49e-03 0.34600 2.06e-01 0.279000 2.92e-03 5.58e-05
LONG TERM POTENTIATION 23 4.84e-02 1.69e-01 0.34600 -2.79e-01 -0.205000 2.06e-02 8.81e-02
SIGNALING BY ROBO RECEPTORS 205 2.20e-14 1.89e-12 0.34500 1.26e-01 0.321000 1.83e-03 2.19e-15
DARPP 32 EVENTS 23 5.31e-02 1.81e-01 0.34400 -2.22e-01 -0.264000 6.59e-02 2.86e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 1.92e-01 4.03e-01 0.34400 2.57e-01 0.230000 1.09e-01 1.51e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 2.26e-02 1.00e-01 0.34400 2.58e-02 0.343000 8.46e-01 9.65e-03
PROLONGED ERK ACTIVATION EVENTS 14 1.34e-01 3.24e-01 0.34300 -3.09e-01 -0.150000 4.56e-02 3.31e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 8.65e-03 4.96e-02 0.34300 -7.92e-02 0.334000 5.50e-01 1.18e-02
RESOLUTION OF D LOOP STRUCTURES 30 1.41e-02 7.37e-02 0.34200 -1.53e-01 -0.306000 1.47e-01 3.68e-03
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 9.85e-03 5.54e-02 0.34200 3.40e-01 -0.041200 8.51e-03 7.50e-01
DAG AND IP3 SIGNALING 40 6.93e-03 4.18e-02 0.34200 -2.45e-01 -0.239000 7.43e-03 9.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42 18 7.42e-03 4.43e-02 0.34200 -1.38e-01 0.313000 3.12e-01 2.17e-02
MISMATCH REPAIR 14 1.73e-01 3.81e-01 0.34100 2.21e-01 0.261000 1.53e-01 9.12e-02
PROCESSING OF INTRONLESS PRE MRNAS 19 6.25e-02 2.03e-01 0.34100 -1.39e-01 -0.312000 2.94e-01 1.87e-02
HDMS DEMETHYLATE HISTONES 28 3.03e-02 1.24e-01 0.34100 -2.18e-01 -0.262000 4.61e-02 1.64e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.77e-01 3.88e-01 0.33900 -1.04e-01 -0.323000 5.50e-01 6.39e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 7.74e-02 2.31e-01 0.33700 -3.19e-01 0.110000 8.07e-02 5.47e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 4.80e-02 1.69e-01 0.33600 2.74e-02 0.335000 8.49e-01 2.03e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 10 2.93e-01 5.27e-01 0.33600 -2.65e-01 -0.206000 1.46e-01 2.58e-01
METABOLISM OF STEROID HORMONES 21 6.75e-02 2.11e-01 0.33600 2.85e-01 0.178000 2.39e-02 1.58e-01
CA DEPENDENT EVENTS 36 1.30e-02 6.92e-02 0.33500 -2.58e-01 -0.213000 7.37e-03 2.71e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 3.01e-05 5.20e-04 0.33400 1.90e-01 0.275000 2.57e-03 1.32e-05
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 83 2.84e-05 4.98e-04 0.33300 1.74e-01 0.283000 6.14e-03 8.10e-06
ARACHIDONIC ACID METABOLISM 38 4.79e-04 5.16e-03 0.33300 -5.60e-03 0.332000 9.52e-01 3.90e-04
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 8.79e-02 2.48e-01 0.33200 -1.21e-01 -0.309000 3.88e-01 2.74e-02
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.90e-04 2.40e-03 0.33200 -2.20e-01 -0.248000 1.17e-03 2.45e-04
TNFR2 NON CANONICAL NF KB PATHWAY 79 1.13e-04 1.56e-03 0.32900 2.24e-01 0.241000 5.81e-04 2.15e-04
COMPLEMENT CASCADE 25 1.42e-02 7.37e-02 0.32900 4.97e-02 0.325000 6.67e-01 4.94e-03
SULFUR AMINO ACID METABOLISM 22 7.40e-02 2.24e-01 0.32800 1.95e-01 0.264000 1.14e-01 3.18e-02
FCERI MEDIATED NF KB ACTIVATION 77 1.06e-04 1.50e-03 0.32600 1.79e-01 0.272000 6.57e-03 3.71e-05
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 2.23e-02 9.97e-02 0.32500 -4.47e-02 0.322000 7.43e-01 1.79e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.39e-02 2.40e-01 0.32500 2.69e-01 0.182000 3.26e-02 1.50e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 6.07e-02 1.98e-01 0.32400 -1.63e-01 -0.280000 1.76e-01 2.01e-02
ACTIVATION OF BH3 ONLY PROTEINS 30 1.75e-02 8.37e-02 0.32400 -1.22e-01 -0.300000 2.47e-01 4.45e-03
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 3.82e-02 1.46e-01 0.32300 2.02e-01 0.252000 5.96e-02 1.91e-02
HEME SIGNALING 45 3.29e-03 2.33e-02 0.32200 -2.90e-01 -0.140000 7.53e-04 1.04e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.57e-02 7.94e-02 0.32100 -2.07e-01 0.246000 1.53e-01 8.86e-02
SHC1 EVENTS IN EGFR SIGNALING 11 6.34e-02 2.04e-01 0.32000 -2.72e-01 0.168000 1.18e-01 3.36e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.68e-01 3.75e-01 0.31800 -1.86e-01 -0.258000 1.97e-01 7.43e-02
ERBB2 REGULATES CELL MOTILITY 14 3.26e-02 1.31e-01 0.31700 -2.75e-01 0.158000 7.49e-02 3.05e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 151 8.96e-09 4.58e-07 0.31500 1.31e-01 0.287000 5.68e-03 1.21e-09
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 3.44e-02 1.36e-01 0.31400 3.06e-01 0.067500 1.10e-02 5.76e-01
HEDGEHOG ON STATE 82 1.71e-04 2.21e-03 0.31400 1.98e-01 0.243000 1.95e-03 1.42e-04
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 4.65e-02 1.67e-01 0.31300 -3.06e-01 -0.067500 1.52e-02 5.92e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 2.82e-01 5.17e-01 0.31200 1.97e-01 0.243000 2.39e-01 1.46e-01
REGULATION OF TNFR1 SIGNALING 34 2.80e-02 1.17e-01 0.31200 1.97e-01 0.242000 4.65e-02 1.46e-02
INTERLEUKIN 6 FAMILY SIGNALING 20 6.37e-02 2.04e-01 0.31100 8.17e-02 0.300000 5.27e-01 2.02e-02
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 4.78e-02 1.69e-01 0.31100 3.73e-02 -0.308000 7.96e-01 3.27e-02
ACYL CHAIN REMODELLING OF PC 16 4.70e-02 1.68e-01 0.30800 -4.63e-02 0.305000 7.48e-01 3.50e-02
PROTEIN METHYLATION 17 1.07e-01 2.78e-01 0.30800 8.99e-02 0.294000 5.21e-01 3.57e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 6.29e-02 2.03e-01 0.30700 3.48e-02 -0.305000 8.16e-01 4.11e-02
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 2.17e-01 4.39e-01 0.30600 -2.65e-01 -0.154000 8.62e-02 3.18e-01
CARDIAC CONDUCTION 109 1.94e-05 3.62e-04 0.30600 -2.20e-01 -0.213000 7.16e-05 1.23e-04
PINK1 PRKN MEDIATED MITOPHAGY 22 8.20e-02 2.38e-01 0.30600 1.35e-01 0.274000 2.74e-01 2.59e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 1.50e-02 7.64e-02 0.30500 -3.42e-02 0.304000 7.77e-01 1.17e-02
HEDGEHOG OFF STATE 106 7.67e-06 1.67e-04 0.30500 2.71e-01 0.139000 1.43e-06 1.34e-02
SHC1 EVENTS IN ERBB2 SIGNALING 21 1.29e-02 6.87e-02 0.30400 -2.89e-01 0.096700 2.20e-02 4.43e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.26e-04 1.70e-03 0.30400 3.00e-01 -0.048800 3.24e-04 5.59e-01
INITIAL TRIGGERING OF COMPLEMENT 11 1.66e-01 3.72e-01 0.30400 5.37e-03 0.304000 9.75e-01 8.13e-02
TRNA AMINOACYLATION 42 1.13e-03 1.02e-02 0.30300 3.03e-01 0.008300 6.72e-04 9.26e-01
G PROTEIN MEDIATED EVENTS 52 4.90e-03 3.17e-02 0.30300 -2.50e-01 -0.172000 1.82e-03 3.23e-02
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 3.01e-01 5.36e-01 0.30300 2.42e-01 0.181000 1.47e-01 2.77e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 6.00e-02 1.98e-01 0.30200 -3.02e-01 -0.018100 2.66e-02 8.94e-01
ACTIVATION OF RAC1 13 2.81e-01 5.17e-01 0.30200 -2.27e-01 -0.199000 1.57e-01 2.13e-01
HS GAG DEGRADATION 21 6.64e-02 2.08e-01 0.30200 2.91e-01 0.080300 2.12e-02 5.24e-01
LYSINE CATABOLISM 11 2.38e-01 4.67e-01 0.30100 7.61e-02 0.291000 6.62e-01 9.42e-02
SIGNAL AMPLIFICATION 30 6.15e-03 3.80e-02 0.30100 -1.59e-02 0.301000 8.80e-01 4.37e-03
INTERLEUKIN 7 SIGNALING 19 1.66e-02 8.22e-02 0.30000 1.38e-01 -0.267000 2.99e-01 4.39e-02
GLYCOLYSIS 66 8.79e-07 3.04e-05 0.30000 1.24e-01 -0.273000 8.05e-02 1.23e-04
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 25 1.08e-02 5.94e-02 0.30000 -4.56e-02 0.296000 6.93e-01 1.03e-02
METABOLISM OF FAT SOLUBLE VITAMINS 35 2.30e-02 1.01e-01 0.30000 2.67e-01 0.137000 6.37e-03 1.60e-01
JOSEPHIN DOMAIN DUBS 11 2.71e-01 5.07e-01 0.29800 2.81e-01 0.101000 1.07e-01 5.63e-01
RHO GTPASES ACTIVATE CIT 18 4.99e-02 1.73e-01 0.29800 -1.57e-02 0.298000 9.08e-01 2.87e-02
POLYMERASE SWITCHING 14 2.61e-01 4.99e-01 0.29800 1.87e-01 0.232000 2.25e-01 1.33e-01
IRAK4 DEFICIENCY TLR2 4 13 5.74e-02 1.92e-01 0.29800 -1.68e-01 0.246000 2.96e-01 1.24e-01
NETRIN 1 SIGNALING 49 5.33e-03 3.39e-02 0.29800 -1.34e-01 -0.266000 1.05e-01 1.29e-03
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 3.15e-01 5.43e-01 0.29600 1.77e-01 0.237000 2.87e-01 1.54e-01
CYTOPROTECTION BY HMOX1 119 4.76e-06 1.19e-04 0.29500 1.38e-01 0.261000 9.31e-03 9.27e-07
ERBB2 ACTIVATES PTK6 SIGNALING 11 1.49e-01 3.45e-01 0.29500 -2.92e-01 0.040000 9.36e-02 8.18e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 9.13e-02 2.53e-01 0.29500 -6.74e-02 0.287000 6.74e-01 7.35e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.44e-01 4.76e-01 0.29400 -1.80e-01 -0.232000 2.28e-01 1.19e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 1.53e-02 7.76e-02 0.29200 5.40e-02 0.287000 5.97e-01 4.94e-03
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 6.03e-04 6.33e-03 0.29200 1.15e-01 0.268000 9.98e-02 1.18e-04
INTERLEUKIN 15 SIGNALING 12 1.81e-01 3.92e-01 0.29200 -2.46e-02 -0.290000 8.83e-01 8.15e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 7.13e-02 2.19e-01 0.29100 2.59e-01 0.133000 2.25e-02 2.40e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 2.93e-02 1.21e-01 0.29100 2.35e-01 0.171000 1.21e-02 6.82e-02
FCERI MEDIATED CA 2 MOBILIZATION 26 1.95e-02 9.10e-02 0.29000 -2.90e-01 0.001050 1.05e-02 9.93e-01
OLFACTORY SIGNALING PATHWAY 25 6.40e-02 2.05e-01 0.28900 -2.71e-01 -0.102000 1.91e-02 3.77e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.55e-01 4.91e-01 0.28900 -1.76e-01 -0.229000 2.37e-01 1.24e-01
TRAFFICKING OF AMPA RECEPTORS 31 5.12e-02 1.76e-01 0.28900 -1.50e-01 -0.247000 1.48e-01 1.72e-02
CHOLESTEROL BIOSYNTHESIS 24 2.21e-02 9.91e-02 0.28900 2.88e-01 -0.021200 1.46e-02 8.57e-01
SIGNALING BY LEPTIN 10 3.24e-01 5.52e-01 0.28900 2.73e-01 0.093300 1.34e-01 6.10e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 10 4.07e-01 6.27e-01 0.28800 -1.77e-01 -0.227000 3.33e-01 2.14e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 1.25e-01 3.11e-01 0.28800 -2.22e-01 0.183000 2.25e-01 3.16e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 5.62e-02 1.89e-01 0.28700 -2.49e-01 -0.143000 1.83e-02 1.75e-01
FGFR2 ALTERNATIVE SPLICING 25 1.01e-01 2.70e-01 0.28700 1.62e-01 0.236000 1.60e-01 4.07e-02
PHASE I FUNCTIONALIZATION OF COMPOUNDS 61 1.34e-03 1.16e-02 0.28700 9.92e-02 0.269000 1.80e-01 2.80e-04
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.79e-01 3.89e-01 0.28500 -1.62e-01 -0.235000 2.22e-01 7.63e-02
GAP JUNCTION TRAFFICKING AND REGULATION 33 1.50e-02 7.65e-02 0.28500 2.81e-01 0.044700 5.17e-03 6.57e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 7.67e-02 2.29e-01 0.28400 -2.44e-01 0.147000 1.28e-01 3.60e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 7.15e-02 2.19e-01 0.28400 -1.15e-01 -0.260000 3.11e-01 2.17e-02
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.27e-01 3.16e-01 0.28400 -2.69e-01 -0.092400 4.27e-02 4.86e-01
BIOLOGICAL OXIDATIONS 125 9.66e-07 3.24e-05 0.28300 8.24e-02 0.271000 1.12e-01 1.69e-07
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 2.74e-03 2.02e-02 0.28300 1.45e-01 0.243000 4.49e-02 7.68e-04
PEXOPHAGY 11 3.45e-01 5.68e-01 0.28300 2.53e-01 0.128000 1.47e-01 4.62e-01
TRANSCRIPTIONAL REGULATION BY MECP2 59 1.68e-03 1.39e-02 0.28200 -2.68e-01 -0.087700 3.69e-04 2.44e-01
UCH PROTEINASES 89 5.02e-04 5.36e-03 0.28200 1.80e-01 0.217000 3.43e-03 3.96e-04
GLUCONEOGENESIS 27 1.60e-02 8.02e-02 0.28200 2.80e-01 -0.026300 1.17e-02 8.13e-01
PHASE 2 PLATEAU PHASE 12 1.79e-01 3.88e-01 0.28100 3.84e-03 -0.281000 9.82e-01 9.18e-02
ADHERENS JUNCTIONS INTERACTIONS 30 8.00e-02 2.34e-01 0.28100 -2.08e-01 -0.189000 4.91e-02 7.30e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 92 1.69e-04 2.20e-03 0.28000 1.26e-01 0.250000 3.73e-02 3.38e-05
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 9.13e-03 5.18e-02 0.27800 -2.02e-01 0.192000 8.69e-02 1.04e-01
PARASITE INFECTION 55 4.33e-04 4.85e-03 0.27800 -2.78e-01 0.006150 3.69e-04 9.37e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 7.59e-04 7.69e-03 0.27800 1.33e-01 0.244000 4.17e-02 1.77e-04
RET SIGNALING 37 7.77e-03 4.61e-02 0.27800 -1.73e-02 -0.277000 8.55e-01 3.54e-03
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.16e-01 2.94e-01 0.27700 -1.13e-01 0.253000 5.00e-01 1.29e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 8.89e-02 2.49e-01 0.27700 -2.75e-01 0.033000 5.67e-02 8.19e-01
INTERLEUKIN 1 SIGNALING 96 3.33e-04 3.83e-03 0.27700 1.68e-01 0.220000 4.51e-03 1.90e-04
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 2.73e-01 5.07e-01 0.27600 7.51e-02 0.266000 6.52e-01 1.11e-01
PEROXISOMAL PROTEIN IMPORT 57 2.13e-03 1.65e-02 0.27600 7.41e-02 0.266000 3.33e-01 5.13e-04
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 1.01e-03 9.30e-03 0.27600 1.72e-01 0.216000 6.46e-03 6.40e-04
SUMOYLATION OF DNA REPLICATION PROTEINS 42 1.74e-02 8.32e-02 0.27500 -1.07e-01 -0.254000 2.32e-01 4.41e-03
PROTEIN LOCALIZATION 156 1.90e-06 5.58e-05 0.27500 1.51e-01 0.230000 1.18e-03 7.29e-07
SIGNALING BY NOTCH4 83 9.89e-04 9.15e-03 0.27400 1.54e-01 0.226000 1.54e-02 3.64e-04
AMINE LIGAND BINDING RECEPTORS 29 6.01e-02 1.98e-01 0.27400 -2.54e-01 -0.101000 1.77e-02 3.48e-01
ORC1 REMOVAL FROM CHROMATIN 67 2.62e-03 1.96e-02 0.27400 1.29e-01 0.241000 6.88e-02 6.36e-04
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 3.89e-01 6.13e-01 0.27300 1.42e-01 0.233000 4.14e-01 1.80e-01
GLUCOSE METABOLISM 80 4.99e-07 1.96e-05 0.27300 1.39e-01 -0.235000 3.12e-02 2.82e-04
CONSTITUTIVE SIGNALING BY EGFRVIII 15 1.49e-01 3.45e-01 0.27100 -2.71e-01 -0.013200 6.92e-02 9.29e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 2.25e-01 4.46e-01 0.27100 -1.06e-01 -0.249000 4.64e-01 8.42e-02
NCAM1 INTERACTIONS 41 2.93e-03 2.11e-02 0.27100 2.74e-02 -0.269000 7.62e-01 2.85e-03
PHASE II CONJUGATION OF COMPOUNDS 61 9.49e-04 9.06e-03 0.27000 4.31e-02 0.267000 5.60e-01 3.14e-04
METHYLATION 12 3.39e-01 5.67e-01 0.27000 1.13e-01 0.245000 4.97e-01 1.42e-01
ZINC TRANSPORTERS 16 1.28e-01 3.16e-01 0.27000 -2.70e-01 -0.005530 6.18e-02 9.69e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 4.28e-01 6.51e-01 0.26900 1.89e-01 0.191000 2.77e-01 2.72e-01
FATTY ACID METABOLISM 145 1.46e-07 6.14e-06 0.26800 5.19e-02 0.263000 2.81e-01 4.55e-08
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 3.66e-03 2.56e-02 0.26800 -2.03e-01 -0.176000 2.76e-03 9.53e-03
SIGNALING BY ERBB2 IN CANCER 25 2.97e-02 1.22e-01 0.26700 -2.65e-01 0.033400 2.20e-02 7.73e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 6.26e-02 2.03e-01 0.26600 1.06e-01 0.244000 3.08e-01 1.86e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 3.40e-01 5.67e-01 0.26600 1.02e-01 0.245000 5.39e-01 1.42e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 3.32e-01 5.61e-01 0.26500 -2.47e-01 -0.095800 1.38e-01 5.66e-01
HSF1 ACTIVATION 25 8.38e-02 2.40e-01 0.26500 2.55e-01 0.072900 2.73e-02 5.28e-01
NUCLEOBASE CATABOLISM 31 3.24e-02 1.30e-01 0.26500 3.93e-02 0.262000 7.05e-01 1.17e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 2.06e-03 1.63e-02 0.26400 1.65e-01 0.206000 9.78e-03 1.24e-03
PEROXISOMAL LIPID METABOLISM 26 7.32e-02 2.22e-01 0.26400 6.64e-02 0.256000 5.58e-01 2.40e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 1.73e-01 3.81e-01 0.26400 -9.36e-04 0.264000 9.95e-01 8.73e-02
CELL CELL JUNCTION ORGANIZATION 49 2.57e-02 1.10e-01 0.26400 -2.02e-01 -0.170000 1.44e-02 4.01e-02
PURINE CATABOLISM 16 1.23e-01 3.08e-01 0.26300 -1.69e-02 0.263000 9.07e-01 6.88e-02
INSULIN PROCESSING 24 1.57e-01 3.57e-01 0.26300 -2.17e-01 -0.149000 6.60e-02 2.07e-01
NEUROTRANSMITTER RELEASE CYCLE 49 2.29e-02 1.01e-01 0.26300 -2.18e-01 -0.147000 8.37e-03 7.45e-02
SIGNALING BY PDGFR IN DISEASE 20 2.20e-01 4.41e-01 0.26200 -2.12e-01 -0.155000 1.01e-01 2.31e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.01e-01 2.70e-01 0.26200 -8.07e-02 0.249000 5.89e-01 9.44e-02
SIGNALING BY BMP 25 6.83e-02 2.12e-01 0.26200 -2.59e-01 -0.042200 2.52e-02 7.15e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 4.41e-02 1.62e-01 0.26100 1.24e-01 -0.230000 3.51e-01 8.24e-02
METAL ION SLC TRANSPORTERS 25 4.73e-02 1.68e-01 0.26100 -2.61e-01 -0.001060 2.38e-02 9.93e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 1.16e-01 2.94e-01 0.26100 -2.20e-01 -0.141000 4.42e-02 1.97e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 4.36e-02 1.62e-01 0.26100 -3.76e-02 0.258000 7.55e-01 3.23e-02
DNA REPLICATION PRE INITIATION 79 2.23e-03 1.70e-02 0.26100 1.37e-01 0.222000 3.52e-02 6.62e-04
MAPK6 MAPK4 SIGNALING 83 9.64e-04 9.06e-03 0.26000 1.09e-01 0.236000 8.65e-02 1.99e-04
FCERI MEDIATED MAPK ACTIVATION 28 1.20e-01 3.02e-01 0.25900 -2.18e-01 -0.141000 4.64e-02 1.98e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.32e-01 3.21e-01 0.25900 -1.77e-01 0.188000 2.87e-01 2.59e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 3.82e-01 6.07e-01 0.25900 -1.19e-01 -0.229000 4.75e-01 1.69e-01
MRNA SPLICING MINOR PATHWAY 52 2.31e-02 1.01e-01 0.25800 2.04e-01 0.159000 1.10e-02 4.76e-02
GLYCOSPHINGOLIPID METABOLISM 38 4.50e-02 1.62e-01 0.25800 1.12e-01 0.233000 2.32e-01 1.31e-02
TIE2 SIGNALING 17 9.31e-02 2.57e-01 0.25800 -2.53e-01 0.053500 7.13e-02 7.02e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 1.20e-01 3.02e-01 0.25800 -2.56e-01 -0.036400 4.78e-02 7.78e-01
NUCLEAR ENVELOPE BREAKDOWN 49 1.83e-02 8.71e-02 0.25800 -1.12e-01 -0.233000 1.77e-01 4.82e-03
CROSSLINKING OF COLLAGEN FIBRILS 16 8.39e-02 2.40e-01 0.25800 2.37e-01 -0.102000 1.01e-01 4.80e-01
INTERFERON ALPHA BETA SIGNALING 55 1.05e-04 1.50e-03 0.25700 -1.83e-01 0.180000 1.87e-02 2.10e-02
UNFOLDED PROTEIN RESPONSE UPR 86 2.53e-04 3.03e-03 0.25600 2.50e-01 0.058500 6.36e-05 3.48e-01
DISEASES OF IMMUNE SYSTEM 24 3.80e-02 1.46e-01 0.25500 -5.30e-02 0.250000 6.53e-01 3.43e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 8.93e-02 2.50e-01 0.25500 -2.55e-01 0.010500 4.85e-02 9.35e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 2.85e-01 5.19e-01 0.25500 -2.49e-01 -0.055300 1.21e-01 7.30e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 9.12e-02 2.53e-01 0.25400 2.19e-01 0.129000 3.18e-02 2.06e-01
SIGNALING BY HIPPO 20 1.89e-01 3.99e-01 0.25400 -2.36e-01 -0.095600 6.80e-02 4.59e-01
EFFECTS OF PIP2 HYDROLYSIS 27 1.56e-01 3.55e-01 0.25400 -1.72e-01 -0.187000 1.22e-01 9.29e-02
COLLAGEN CHAIN TRIMERIZATION 40 2.23e-03 1.70e-02 0.25400 1.12e-01 -0.228000 2.22e-01 1.27e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 6.61e-02 2.08e-01 0.25300 -7.84e-02 0.241000 5.54e-01 6.90e-02
FORMATION OF APOPTOSOME 10 2.21e-01 4.41e-01 0.25300 -1.07e-01 0.229000 5.57e-01 2.09e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 3.04e-01 5.37e-01 0.25300 -1.05e-01 -0.230000 4.80e-01 1.23e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 1.51e-01 3.48e-01 0.25200 -1.43e-01 0.207000 3.90e-01 2.14e-01
PYRIMIDINE SALVAGE 10 3.89e-01 6.13e-01 0.25200 2.46e-01 0.053400 1.78e-01 7.70e-01
RORA ACTIVATES GENE EXPRESSION 18 7.91e-02 2.34e-01 0.25100 -2.39e-01 0.079000 7.98e-02 5.62e-01
CA2 PATHWAY 57 2.62e-04 3.08e-03 0.25100 -2.34e-01 0.092500 2.29e-03 2.27e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 58 1.01e-02 5.68e-02 0.25100 -1.01e-01 -0.230000 1.83e-01 2.46e-03
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 2.55e-01 4.91e-01 0.25100 1.97e-01 0.156000 1.28e-01 2.27e-01
ION HOMEOSTASIS 49 3.68e-02 1.43e-01 0.25100 -1.89e-01 -0.165000 2.20e-02 4.60e-02
RAP1 SIGNALLING 15 3.60e-01 5.86e-01 0.25100 -1.95e-01 -0.157000 1.90e-01 2.92e-01
NEURONAL SYSTEM 368 2.15e-11 1.34e-09 0.25000 -1.54e-01 -0.197000 3.80e-07 9.33e-11
CLEC7A DECTIN 1 SIGNALING 95 8.41e-04 8.12e-03 0.25000 1.16e-01 0.222000 5.08e-02 1.89e-04
GLYCOGEN METABOLISM 25 1.82e-01 3.92e-01 0.25000 1.53e-01 0.198000 1.87e-01 8.64e-02
ELASTIC FIBRE FORMATION 38 3.99e-02 1.50e-01 0.25000 7.87e-02 0.237000 4.02e-01 1.14e-02
HSF1 DEPENDENT TRANSACTIVATION 33 3.82e-02 1.46e-01 0.25000 2.47e-01 0.036100 1.40e-02 7.20e-01
HYALURONAN UPTAKE AND DEGRADATION 11 4.66e-01 6.80e-01 0.24900 1.40e-01 0.206000 4.22e-01 2.36e-01
ATTENUATION PHASE 23 1.13e-01 2.89e-01 0.24900 2.45e-01 0.046100 4.21e-02 7.02e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 1.06e-01 2.76e-01 0.24900 2.16e-01 -0.123000 1.47e-01 4.10e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 1.17e-01 2.96e-01 0.24800 -2.28e-01 0.097400 1.26e-01 5.14e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 1.86e-01 3.95e-01 0.24800 4.76e-02 0.243000 7.27e-01 7.40e-02
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 1.61e-02 8.02e-02 0.24700 -2.31e-02 0.246000 8.13e-01 1.18e-02
RHO GTPASES ACTIVATE IQGAPS 24 1.07e-01 2.78e-01 0.24700 2.43e-01 0.046000 3.96e-02 6.97e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.54e-01 6.77e-01 0.24700 -9.12e-02 -0.229000 6.18e-01 2.09e-01
PLATELET CALCIUM HOMEOSTASIS 26 1.81e-01 3.92e-01 0.24600 -1.50e-01 -0.195000 1.86e-01 8.55e-02
INFLAMMASOMES 19 2.85e-01 5.19e-01 0.24600 1.48e-01 0.196000 2.65e-01 1.38e-01
ANTIMICROBIAL PEPTIDES 18 3.10e-01 5.42e-01 0.24500 1.55e-01 0.191000 2.56e-01 1.62e-01
PI METABOLISM 79 6.24e-03 3.84e-02 0.24500 -1.60e-01 -0.186000 1.40e-02 4.34e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.29e-01 4.52e-01 0.24500 1.66e-01 0.180000 1.69e-01 1.34e-01
NUCLEOTIDE SALVAGE 21 2.16e-01 4.38e-01 0.24500 2.20e-01 0.107000 8.09e-02 3.96e-01
SIGNALING BY HEDGEHOG 141 4.57e-05 7.46e-04 0.24400 2.17e-01 0.111000 8.96e-06 2.27e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 4.73e-01 6.84e-01 0.24200 1.21e-01 0.209000 4.86e-01 2.29e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 10 5.36e-01 7.30e-01 0.24200 -1.72e-01 -0.170000 3.45e-01 3.53e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 3.98e-02 1.50e-01 0.24100 -1.76e-01 -0.165000 2.81e-02 3.95e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 94 2.04e-03 1.63e-02 0.24100 1.28e-01 0.204000 3.19e-02 6.20e-04
SEMA4D IN SEMAPHORIN SIGNALING 24 2.24e-01 4.44e-01 0.24100 1.58e-01 0.183000 1.81e-01 1.22e-01
GLYCOGEN SYNTHESIS 14 4.05e-01 6.25e-01 0.24100 1.37e-01 0.198000 3.74e-01 1.99e-01
RAS PROCESSING 24 1.56e-01 3.55e-01 0.24100 8.08e-02 0.227000 4.93e-01 5.42e-02
APOPTOTIC FACTOR MEDIATED RESPONSE 18 8.44e-02 2.41e-01 0.24100 -1.05e-01 0.217000 4.42e-01 1.11e-01
AURKA ACTIVATION BY TPX2 71 8.41e-04 8.12e-03 0.24100 -1.11e-02 -0.240000 8.72e-01 4.65e-04
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 5.13e-03 3.28e-02 0.23900 2.33e-01 -0.051100 7.40e-03 5.58e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 2.33e-01 4.58e-01 0.23900 1.71e-01 0.167000 1.48e-01 1.57e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 3.13e-01 5.43e-01 0.23900 1.82e-01 0.154000 1.69e-01 2.46e-01
INTERFERON GAMMA SIGNALING 77 3.60e-05 6.04e-04 0.23900 -2.18e-01 0.097800 9.71e-04 1.38e-01
GAB1 SIGNALOSOME 14 3.12e-01 5.43e-01 0.23800 -2.31e-01 -0.054000 1.34e-01 7.27e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 8.28e-02 2.40e-01 0.23700 -9.31e-02 -0.218000 3.41e-01 2.57e-02
VLDLR INTERNALISATION AND DEGRADATION 12 3.30e-01 5.59e-01 0.23700 2.36e-01 0.024400 1.58e-01 8.84e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 2.96e-01 5.29e-01 0.23600 -1.88e-01 -0.144000 1.46e-01 2.66e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 3.84e-03 2.61e-02 0.23600 1.17e-01 0.205000 5.99e-02 1.03e-03
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.07e-02 2.53e-01 0.23600 -2.27e-01 0.061300 7.83e-02 6.35e-01
SIGNALING BY FGFR1 IN DISEASE 33 1.25e-01 3.11e-01 0.23500 -2.00e-01 -0.123000 4.66e-02 2.22e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.49e-01 5.73e-01 0.23400 -1.69e-01 -0.163000 2.15e-01 2.33e-01
RMTS METHYLATE HISTONE ARGININES 44 4.69e-02 1.68e-01 0.23400 2.16e-01 0.091300 1.34e-02 2.95e-01
ACYL CHAIN REMODELLING OF PE 16 1.16e-01 2.95e-01 0.23400 -1.24e-01 0.199000 3.90e-01 1.69e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 6.55e-04 6.81e-03 0.23400 2.26e-01 -0.060800 2.09e-03 4.08e-01
VIRAL MESSENGER RNA SYNTHESIS 42 2.68e-02 1.13e-01 0.23400 -3.46e-02 -0.231000 6.98e-01 9.59e-03
SIGNALING BY FLT3 FUSION PROTEINS 19 2.91e-01 5.27e-01 0.23300 -2.06e-01 -0.108000 1.19e-01 4.14e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 3.05e-01 5.37e-01 0.23300 -7.18e-02 -0.222000 6.19e-01 1.25e-01
PLASMA LIPOPROTEIN CLEARANCE 28 1.64e-01 3.69e-01 0.23300 2.06e-01 0.109000 5.97e-02 3.17e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 2.88e-01 5.22e-01 0.23300 8.95e-02 0.215000 5.11e-01 1.14e-01
GLUCAGON TYPE LIGAND RECEPTORS 25 1.39e-01 3.30e-01 0.23300 5.45e-02 0.226000 6.37e-01 5.04e-02
INTERLEUKIN 10 SIGNALING 19 1.38e-01 3.30e-01 0.23200 -2.31e-01 0.021600 8.09e-02 8.71e-01
DEADENYLATION OF MRNA 25 1.37e-01 3.28e-01 0.23200 -2.26e-01 -0.052000 5.02e-02 6.53e-01
PROTEIN FOLDING 89 6.04e-03 3.77e-02 0.23200 1.74e-01 0.154000 4.62e-03 1.22e-02
RHOJ GTPASE CYCLE 54 2.61e-02 1.11e-01 0.23200 -2.12e-01 -0.093500 6.96e-03 2.35e-01
DISEASES OF METABOLISM 197 8.67e-06 1.82e-04 0.23200 1.91e-01 0.132000 4.09e-06 1.40e-03
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 3.01e-01 5.36e-01 0.23200 -1.64e-01 -0.164000 1.93e-01 1.94e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 6.05e-02 1.98e-01 0.23200 -2.08e-01 -0.102000 1.83e-02 2.47e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 1.70e-01 3.78e-01 0.23100 1.89e-01 0.133000 7.36e-02 2.07e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 12 2.66e-01 5.04e-01 0.23100 4.36e-02 -0.227000 7.94e-01 1.74e-01
GABA RECEPTOR ACTIVATION 53 3.12e-02 1.27e-01 0.23000 -2.09e-01 -0.097500 8.60e-03 2.20e-01
EARLY PHASE OF HIV LIFE CYCLE 13 4.65e-01 6.80e-01 0.23000 -1.90e-01 -0.130000 2.36e-01 4.18e-01
ACTIVATION OF SMO 16 3.42e-01 5.67e-01 0.22900 2.11e-01 0.088600 1.43e-01 5.39e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.92e-01 4.03e-01 0.22900 1.98e-01 0.115000 7.43e-02 3.02e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.01e-01 2.70e-01 0.22800 -1.84e-01 -0.135000 4.39e-02 1.39e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 4.83e-01 6.92e-01 0.22800 1.46e-01 0.175000 3.61e-01 2.75e-01
DAP12 INTERACTIONS 31 1.72e-02 8.32e-02 0.22800 -1.66e-01 0.156000 1.10e-01 1.33e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 12 2.63e-01 5.02e-01 0.22700 -5.94e-02 0.219000 7.22e-01 1.89e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 4.72e-01 6.83e-01 0.22600 1.90e-01 0.123000 2.36e-01 4.42e-01
RECYCLING PATHWAY OF L1 40 1.47e-02 7.54e-02 0.22500 2.20e-01 -0.045700 1.59e-02 6.17e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 4.43e-02 1.62e-01 0.22500 -5.21e-02 0.219000 6.27e-01 4.14e-02
DNA METHYLATION 21 3.04e-01 5.37e-01 0.22500 1.25e-01 0.187000 3.23e-01 1.38e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 64 2.62e-02 1.11e-01 0.22400 1.90e-01 0.120000 8.75e-03 9.81e-02
RNA POLYMERASE III CHAIN ELONGATION 18 2.21e-01 4.41e-01 0.22400 2.23e-01 0.019000 1.01e-01 8.89e-01
ERK MAPK TARGETS 22 3.02e-01 5.37e-01 0.22400 -1.38e-01 -0.176000 2.62e-01 1.53e-01
RHOQ GTPASE CYCLE 58 2.05e-02 9.41e-02 0.22400 -2.11e-01 -0.073600 5.38e-03 3.32e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 2.53e-01 4.90e-01 0.22300 -1.61e-01 -0.154000 1.55e-01 1.74e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 2.08e-01 4.27e-01 0.22300 1.36e-01 0.177000 2.05e-01 9.97e-02
MITOTIC TELOPHASE CYTOKINESIS 13 3.73e-01 5.98e-01 0.22300 -2.19e-01 -0.041500 1.72e-01 7.96e-01
TIGHT JUNCTION INTERACTIONS 17 3.35e-01 5.64e-01 0.22200 -2.07e-01 -0.080600 1.39e-01 5.65e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.69e-01 3.78e-01 0.22200 2.20e-01 -0.030800 1.06e-01 8.21e-01
SELECTIVE AUTOPHAGY 72 4.69e-03 3.08e-02 0.22100 2.17e-01 0.042100 1.43e-03 5.37e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 2.18e-01 4.40e-01 0.22100 -2.17e-01 0.043500 1.46e-01 7.70e-01
PRC2 METHYLATES HISTONES AND DNA 30 1.37e-01 3.29e-01 0.22100 7.00e-02 0.210000 5.07e-01 4.69e-02
REGULATION OF BETA CELL DEVELOPMENT 28 1.97e-01 4.10e-01 0.22100 -1.03e-01 -0.195000 3.43e-01 7.38e-02
TCR SIGNALING 100 2.14e-03 1.65e-02 0.22000 8.46e-02 0.203000 1.44e-01 4.55e-04
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 2.72e-01 5.07e-01 0.22000 1.69e-01 0.140000 1.43e-01 2.25e-01
RNA POLYMERASE I PROMOTER ESCAPE 48 3.75e-02 1.45e-01 0.21900 5.70e-02 0.211000 4.95e-01 1.13e-02
RESPONSE OF MTB TO PHAGOCYTOSIS 21 2.41e-01 4.72e-01 0.21900 2.11e-01 0.059600 9.48e-02 6.36e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 4.67e-01 6.81e-01 0.21900 -1.97e-01 -0.095500 2.19e-01 5.51e-01
RNA POLYMERASE I TRANSCRIPTION 68 2.11e-02 9.65e-02 0.21900 1.03e-01 0.193000 1.43e-01 5.92e-03
RUNX3 REGULATES NOTCH SIGNALING 13 4.94e-01 7.04e-01 0.21900 -1.85e-01 -0.117000 2.49e-01 4.65e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 2.04e-01 4.19e-01 0.21800 1.24e-01 0.180000 2.39e-01 8.86e-02
CD28 DEPENDENT VAV1 PATHWAY 11 2.73e-01 5.07e-01 0.21700 -1.30e-01 0.174000 4.54e-01 3.18e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 1.71e-01 3.78e-01 0.21700 -8.12e-02 -0.202000 4.49e-01 6.01e-02
ASSEMBLY OF THE HIV VIRION 16 4.36e-01 6.61e-01 0.21700 1.75e-01 0.128000 2.25e-01 3.74e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 1.20e-04 1.64e-03 0.21700 2.12e-01 -0.048200 4.85e-04 4.27e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 2.28e-01 4.50e-01 0.21700 1.34e-01 0.171000 2.12e-01 1.12e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 5.35e-01 7.30e-01 0.21700 1.77e-01 0.125000 2.87e-01 4.55e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 1.76e-01 3.87e-01 0.21700 -1.18e-01 0.182000 4.30e-01 2.23e-01
LAGGING STRAND SYNTHESIS 20 3.67e-01 5.92e-01 0.21700 1.61e-01 0.145000 2.12e-01 2.63e-01
OTHER SEMAPHORIN INTERACTIONS 19 3.81e-01 6.07e-01 0.21700 -1.69e-01 -0.135000 2.02e-01 3.07e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 3.38e-01 5.67e-01 0.21700 1.27e-01 0.175000 3.13e-01 1.65e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.20e-03 1.07e-02 0.21700 7.24e-03 -0.216000 9.12e-01 9.56e-04
BETA CATENIN INDEPENDENT WNT SIGNALING 138 2.42e-04 2.93e-03 0.21600 7.85e-02 0.201000 1.12e-01 4.50e-05
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 2.21e-01 4.41e-01 0.21600 -1.97e-01 -0.088000 8.24e-02 4.38e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.66e-01 6.80e-01 0.21500 2.05e-01 0.065100 2.19e-01 6.96e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 61 6.53e-03 3.97e-02 0.21500 7.47e-05 -0.215000 9.99e-01 3.77e-03
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 5.17e-01 7.22e-01 0.21400 -1.23e-01 -0.175000 4.43e-01 2.75e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 9.58e-02 2.60e-01 0.21400 1.11e-01 -0.182000 3.77e-01 1.48e-01
DISEASES OF DNA REPAIR 11 2.82e-01 5.17e-01 0.21400 1.42e-01 -0.159000 4.13e-01 3.61e-01
SCAVENGING BY CLASS A RECEPTORS 14 5.10e-01 7.17e-01 0.21200 1.42e-01 0.158000 3.58e-01 3.06e-01
HS GAG BIOSYNTHESIS 29 1.84e-01 3.93e-01 0.21200 1.98e-01 0.077200 6.57e-02 4.72e-01
INTERLEUKIN 1 FAMILY SIGNALING 121 2.14e-03 1.65e-02 0.21200 1.13e-01 0.179000 3.23e-02 6.55e-04
P75NTR SIGNALS VIA NF KB 16 4.65e-01 6.80e-01 0.21200 1.58e-01 0.141000 2.75e-01 3.28e-01
TRNA PROCESSING IN THE NUCLEUS 56 4.02e-02 1.51e-01 0.21100 -7.87e-02 -0.196000 3.08e-01 1.12e-02
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 3.19e-01 5.46e-01 0.21100 -8.41e-02 0.194000 6.29e-01 2.66e-01
INTERLEUKIN 12 SIGNALING 37 6.47e-02 2.05e-01 0.21100 1.87e-02 0.210000 8.44e-01 2.71e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 3.39e-01 5.67e-01 0.21100 2.08e-01 -0.034800 2.13e-01 8.35e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 3.58e-01 5.83e-01 0.21100 1.71e-01 0.123000 1.75e-01 3.31e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 20 1.44e-01 3.37e-01 0.21000 -2.02e-01 0.059400 1.18e-01 6.46e-01
G PROTEIN BETA GAMMA SIGNALLING 30 3.51e-02 1.38e-01 0.21000 -1.49e-01 0.148000 1.57e-01 1.61e-01
C TYPE LECTIN RECEPTORS CLRS 111 1.26e-03 1.11e-02 0.20900 6.16e-02 0.200000 2.62e-01 2.79e-04
PECAM1 INTERACTIONS 12 2.68e-01 5.04e-01 0.20900 -1.60e-01 0.134000 3.36e-01 4.22e-01
BIOTIN TRANSPORT AND METABOLISM 11 5.88e-01 7.59e-01 0.20800 1.71e-01 0.119000 3.26e-01 4.95e-01
DERMATAN SULFATE BIOSYNTHESIS 11 4.92e-01 7.02e-01 0.20800 4.38e-02 0.203000 8.01e-01 2.44e-01
HIV ELONGATION ARREST AND RECOVERY 32 9.57e-02 2.60e-01 0.20800 2.07e-01 0.013200 4.25e-02 8.97e-01
MUCOPOLYSACCHARIDOSES 11 5.74e-01 7.55e-01 0.20700 1.81e-01 0.101000 2.98e-01 5.63e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 4.68e-01 6.81e-01 0.20700 3.86e-03 0.207000 9.83e-01 2.57e-01
SYNTHESIS OF PE 13 5.24e-01 7.26e-01 0.20700 1.79e-01 0.105000 2.65e-01 5.12e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 3.74e-01 5.98e-01 0.20700 -1.85e-01 -0.092600 1.63e-01 4.85e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 2.33e-04 2.86e-03 0.20700 7.85e-02 -0.191000 2.11e-01 2.30e-03
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 14 5.28e-01 7.26e-01 0.20700 1.53e-01 0.139000 3.22e-01 3.68e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 5.65e-01 7.52e-01 0.20600 -1.95e-01 -0.067000 2.87e-01 7.14e-01
THE PHOTOTRANSDUCTION CASCADE 21 3.44e-01 5.68e-01 0.20500 -1.83e-01 -0.091800 1.46e-01 4.66e-01
RAB GERANYLGERANYLATION 57 5.06e-02 1.75e-01 0.20500 -1.87e-01 -0.084100 1.47e-02 2.72e-01
KINESINS 47 1.42e-02 7.37e-02 0.20500 1.98e-01 -0.053300 1.91e-02 5.28e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 5.51e-01 7.44e-01 0.20400 1.21e-01 0.165000 4.52e-01 3.03e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 3.66e-01 5.92e-01 0.20400 5.44e-02 0.197000 6.98e-01 1.60e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 4.05e-01 6.25e-01 0.20300 -1.63e-01 -0.122000 2.08e-01 3.46e-01
DNA REPLICATION 121 4.31e-03 2.86e-02 0.20300 1.19e-01 0.164000 2.36e-02 1.84e-03
INTERFERON SIGNALING 164 1.54e-05 3.01e-04 0.20300 -2.02e-01 -0.019400 8.32e-06 6.69e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 4.54e-01 6.77e-01 0.20300 6.43e-03 0.202000 9.71e-01 2.45e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 240 2.25e-05 4.00e-04 0.20200 -1.18e-01 -0.164000 1.65e-03 1.20e-05
FOXO MEDIATED TRANSCRIPTION 58 2.62e-03 1.96e-02 0.20200 -1.54e-01 0.130000 4.22e-02 8.58e-02
RHOH GTPASE CYCLE 37 5.07e-02 1.75e-01 0.20200 -2.64e-02 0.200000 7.81e-01 3.55e-02
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 2.22e-01 4.42e-01 0.20100 1.83e-01 0.084400 8.32e-02 4.24e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 2.05e-03 1.63e-02 0.20100 -1.87e-01 0.073200 8.05e-03 3.00e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 2.05e-02 9.41e-02 0.20100 1.41e-01 0.143000 2.05e-02 1.82e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 3.49e-01 5.73e-01 0.20000 1.21e-01 0.160000 3.06e-01 1.75e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 2.13e-01 4.34e-01 0.20000 -1.89e-01 -0.067700 7.89e-02 5.28e-01
SIGNALING BY CSF3 G CSF 29 1.38e-01 3.30e-01 0.20000 1.28e-02 0.200000 9.05e-01 6.25e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 2.03e-01 4.18e-01 0.20000 1.19e-01 -0.161000 4.11e-01 2.65e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 3.98e-01 6.20e-01 0.19900 1.79e-01 0.086800 1.76e-01 5.13e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 3.14e-01 5.43e-01 0.19800 -1.06e-01 0.168000 5.27e-01 3.14e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 4.42e-04 4.90e-03 0.19800 -1.14e-01 -0.162000 8.77e-03 1.83e-04
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 1.04e-01 2.75e-01 0.19800 -1.27e-03 0.198000 9.90e-01 5.26e-02
MYOGENESIS 25 2.81e-01 5.16e-01 0.19800 -1.84e-01 -0.072200 1.11e-01 5.32e-01
RHOU GTPASE CYCLE 33 2.53e-01 4.90e-01 0.19800 -1.38e-01 -0.142000 1.71e-01 1.59e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 2.02e-01 4.17e-01 0.19700 1.19e-02 0.197000 9.20e-01 9.47e-02
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 5.42e-02 1.84e-01 0.19600 -1.88e-01 -0.054800 1.66e-02 4.86e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 2.26e-01 4.47e-01 0.19600 -1.49e-01 -0.128000 1.23e-01 1.84e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 1.88e-01 3.98e-01 0.19600 3.35e-02 0.193000 7.59e-01 7.67e-02
SIGNALING BY FGFR2 IIIA TM 19 4.60e-01 6.78e-01 0.19600 1.34e-01 0.143000 3.11e-01 2.82e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 4.05e-03 2.72e-02 0.19600 1.95e-01 0.016100 1.76e-03 7.96e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 3.87e-03 2.61e-02 0.19600 6.31e-02 0.185000 2.58e-01 8.86e-04
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 1.54e-01 3.54e-01 0.19500 1.95e-01 0.006290 7.36e-02 9.54e-01
COLLAGEN FORMATION 79 1.72e-03 1.41e-02 0.19500 1.90e-01 -0.044500 3.50e-03 4.94e-01
OPIOID SIGNALLING 86 1.14e-02 6.27e-02 0.19500 -1.86e-01 -0.059400 2.91e-03 3.41e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 8.01e-02 2.34e-01 0.19500 1.80e-01 0.074300 2.46e-02 3.54e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 1.39e-01 3.30e-01 0.19500 1.12e-01 0.160000 1.85e-01 5.85e-02
SIGNALING BY VEGF 103 7.18e-03 4.30e-02 0.19400 -1.79e-01 -0.075100 1.68e-03 1.88e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 3.42e-01 5.67e-01 0.19400 -1.75e-01 0.084900 2.95e-01 6.10e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 3.21e-01 5.47e-01 0.19400 -2.85e-02 0.192000 8.48e-01 1.98e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 3.09e-01 5.41e-01 0.19400 1.71e-01 -0.092100 2.87e-01 5.65e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 33 2.67e-01 5.04e-01 0.19400 1.32e-01 0.142000 1.89e-01 1.59e-01
GLYCOSAMINOGLYCAN METABOLISM 114 8.44e-03 4.91e-02 0.19400 1.62e-01 0.107000 2.91e-03 4.92e-02
CHAPERONE MEDIATED AUTOPHAGY 21 3.64e-01 5.90e-01 0.19400 1.79e-01 0.073300 1.55e-01 5.61e-01
ERYTHROPOIETIN ACTIVATES RAS 13 2.92e-01 5.27e-01 0.19400 -1.34e-01 0.139000 4.02e-01 3.84e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.33e-01 3.24e-01 0.19300 -1.89e-01 0.038000 9.48e-02 7.37e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 4.60e-01 6.78e-01 0.19300 1.89e-01 0.041400 2.22e-01 7.89e-01
SIGNALING BY ERYTHROPOIETIN 24 2.92e-01 5.27e-01 0.19300 -1.84e-01 -0.057500 1.19e-01 6.26e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 6.12e-01 7.75e-01 0.19300 1.14e-01 0.156000 4.96e-01 3.50e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 2.70e-01 5.06e-01 0.19200 1.37e-01 -0.135000 3.73e-01 3.83e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 3.11e-01 5.42e-01 0.19200 -1.65e-01 0.098800 3.04e-01 5.37e-01
MUSCLE CONTRACTION 162 1.67e-03 1.39e-02 0.19200 -1.49e-01 -0.121000 1.06e-03 8.14e-03
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 2.63e-03 1.96e-02 0.19100 1.72e-02 -0.190000 7.85e-01 2.47e-03
G1 S SPECIFIC TRANSCRIPTION 26 3.12e-01 5.43e-01 0.19000 8.00e-02 0.173000 4.80e-01 1.27e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 3.67e-01 5.92e-01 0.19000 1.64e-01 0.096700 1.65e-01 4.12e-01
COLLAGEN DEGRADATION 51 2.00e-02 9.24e-02 0.19000 4.42e-02 -0.185000 5.85e-01 2.24e-02
REGULATION OF IFNA SIGNALING 12 5.57e-01 7.49e-01 0.19000 1.80e-01 0.060700 2.81e-01 7.16e-01
REPRESSION OF WNT TARGET GENES 14 5.75e-01 7.55e-01 0.19000 1.13e-01 0.152000 4.64e-01 3.23e-01
LDL CLEARANCE 16 3.06e-01 5.38e-01 0.18900 1.86e-01 -0.034800 1.97e-01 8.09e-01
POLO LIKE KINASE MEDIATED EVENTS 14 5.87e-01 7.59e-01 0.18900 1.32e-01 0.135000 3.92e-01 3.81e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 6.03e-01 7.68e-01 0.18900 5.08e-02 0.182000 7.81e-01 3.19e-01
REGULATION OF IFNG SIGNALING 13 6.09e-01 7.73e-01 0.18800 1.20e-01 0.145000 4.55e-01 3.65e-01
ACYL CHAIN REMODELLING OF PG 10 4.78e-01 6.89e-01 0.18800 -3.88e-02 0.184000 8.32e-01 3.14e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.26e-02 1.59e-01 0.18700 -1.28e-01 -0.136000 4.08e-02 3.03e-02
THE NLRP3 INFLAMMASOME 15 4.93e-01 7.03e-01 0.18700 1.77e-01 0.060200 2.35e-01 6.87e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 1.26e-02 6.74e-02 0.18700 -1.84e-01 -0.033400 4.07e-03 6.01e-01
FRS MEDIATED FGFR4 SIGNALING 14 4.80e-01 6.89e-01 0.18600 3.73e-02 0.183000 8.09e-01 2.37e-01
NEUTROPHIL DEGRANULATION 385 3.10e-08 1.46e-06 0.18600 6.43e-02 0.175000 3.09e-02 4.23e-09
TNF SIGNALING 43 1.99e-01 4.13e-01 0.18600 1.15e-01 0.147000 1.94e-01 9.63e-02
AMYLOID FIBER FORMATION 59 7.85e-02 2.33e-01 0.18500 7.37e-02 0.170000 3.27e-01 2.41e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.74e-01 3.82e-01 0.18500 1.25e-01 0.136000 1.34e-01 1.03e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 3.91e-01 6.13e-01 0.18500 6.76e-02 -0.172000 6.85e-01 3.02e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 45 8.08e-02 2.35e-01 0.18300 1.61e-02 0.182000 8.52e-01 3.42e-02
PRE NOTCH PROCESSING IN GOLGI 17 5.44e-01 7.38e-01 0.18300 1.35e-01 0.123000 3.34e-01 3.78e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 2.68e-01 5.04e-01 0.18300 8.91e-04 0.183000 9.94e-01 1.37e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 63 8.43e-02 2.41e-01 0.18300 8.88e-02 0.160000 2.23e-01 2.81e-02
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 23 3.15e-01 5.43e-01 0.18300 1.79e-01 0.037300 1.38e-01 7.57e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.93e-01 7.61e-01 0.18300 -8.30e-02 -0.163000 6.05e-01 3.10e-01
EPHRIN SIGNALING 19 2.02e-01 4.17e-01 0.18200 1.31e-01 -0.127000 3.21e-01 3.40e-01
INWARDLY RECTIFYING K CHANNELS 31 2.80e-01 5.15e-01 0.18200 -1.65e-01 -0.076900 1.11e-01 4.59e-01
PLASMA LIPOPROTEIN REMODELING 17 2.72e-01 5.07e-01 0.18200 6.88e-02 -0.169000 6.23e-01 2.28e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 48 1.09e-01 2.80e-01 0.18200 5.12e-02 0.175000 5.39e-01 3.65e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 3.20e-01 5.46e-01 0.18200 6.16e-02 0.171000 5.87e-01 1.31e-01
ERKS ARE INACTIVATED 13 5.57e-01 7.49e-01 0.18100 -5.61e-02 -0.173000 7.26e-01 2.81e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 36 2.80e-01 5.15e-01 0.18100 1.42e-01 0.113000 1.42e-01 2.43e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 5.43e-01 7.37e-01 0.18100 1.65e-01 0.073800 2.69e-01 6.21e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 1.35e-01 3.27e-01 0.18000 -1.80e-01 0.008900 7.36e-02 9.30e-01
ENOS ACTIVATION 11 4.54e-01 6.77e-01 0.17900 -1.71e-01 0.055400 3.27e-01 7.51e-01
SHC MEDIATED CASCADE FGFR4 12 5.27e-01 7.26e-01 0.17900 1.73e-02 0.179000 9.17e-01 2.84e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 4.14e-01 6.34e-01 0.17900 -1.12e-01 0.139000 5.18e-01 4.25e-01
RHOBTB1 GTPASE CYCLE 23 1.65e-01 3.70e-01 0.17900 -1.52e-01 0.094900 2.09e-01 4.31e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 2.59e-02 1.11e-01 0.17900 -5.83e-02 0.169000 4.72e-01 3.69e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 3.73e-01 5.98e-01 0.17900 1.60e-01 -0.079400 3.18e-01 6.20e-01
FORMATION OF THE CORNIFIED ENVELOPE 30 1.13e-01 2.89e-01 0.17900 1.67e-01 -0.063000 1.13e-01 5.50e-01
KERATINIZATION 30 1.13e-01 2.89e-01 0.17900 1.67e-01 -0.063000 1.13e-01 5.50e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 7.55e-02 2.26e-01 0.17800 1.64e-01 -0.069400 9.23e-02 4.78e-01
SIGNALING BY NTRK2 TRKB 24 3.43e-01 5.68e-01 0.17800 -1.71e-01 -0.050200 1.47e-01 6.70e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 3.71e-01 5.98e-01 0.17800 1.74e-01 -0.035800 2.42e-01 8.10e-01
CARNITINE METABOLISM 14 5.43e-01 7.37e-01 0.17800 1.70e-01 0.053300 2.71e-01 7.30e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 1.02e-01 2.71e-01 0.17800 -7.70e-02 -0.160000 3.06e-01 3.32e-02
TELOMERE MAINTENANCE 79 7.01e-02 2.17e-01 0.17800 1.21e-01 0.131000 6.37e-02 4.48e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 1.61e-02 8.02e-02 0.17800 1.14e-01 -0.136000 1.55e-01 8.88e-02
HYALURONAN METABOLISM 15 5.83e-01 7.59e-01 0.17800 9.36e-02 0.151000 5.30e-01 3.12e-01
CITRIC ACID CYCLE TCA CYCLE 22 3.99e-01 6.21e-01 0.17700 1.67e-01 0.060900 1.76e-01 6.21e-01
SLC TRANSPORTER DISORDERS 76 7.38e-02 2.23e-01 0.17700 -1.07e-01 -0.142000 1.08e-01 3.28e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 4.57e-01 6.77e-01 0.17700 1.04e-01 -0.144000 5.70e-01 4.31e-01
AUTOPHAGY 139 1.78e-03 1.45e-02 0.17700 1.72e-01 0.041600 4.64e-04 3.98e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.61e-01 6.78e-01 0.17700 -1.73e-01 0.033800 2.99e-01 8.39e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 3.81e-01 6.07e-01 0.17600 -4.82e-02 -0.170000 6.96e-01 1.69e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 1.31e-01 3.20e-01 0.17600 -7.26e-02 0.160000 5.06e-01 1.42e-01
TELOMERE EXTENSION BY TELOMERASE 22 4.83e-01 6.92e-01 0.17600 1.15e-01 0.133000 3.51e-01 2.81e-01
ANCHORING FIBRIL FORMATION 14 4.10e-01 6.30e-01 0.17500 3.40e-02 -0.172000 8.26e-01 2.65e-01
SIGNALING BY NTRKS 130 3.74e-03 2.60e-02 0.17500 -4.82e-02 -0.168000 3.43e-01 9.18e-04
FORMATION OF THE EARLY ELONGATION COMPLEX 33 2.73e-01 5.07e-01 0.17500 1.62e-01 0.066500 1.07e-01 5.09e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 16 3.91e-01 6.13e-01 0.17500 -1.75e-01 0.013700 2.27e-01 9.24e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 5.71e-01 7.55e-01 0.17500 -1.49e-01 -0.091800 3.02e-01 5.25e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 4.24e-01 6.47e-01 0.17500 1.75e-01 -0.008320 2.41e-01 9.56e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 3.27e-01 5.55e-01 0.17500 1.49e-01 -0.091400 3.19e-01 5.40e-01
DAP12 SIGNALING 24 1.83e-01 3.92e-01 0.17400 -1.60e-01 0.069600 1.75e-01 5.55e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.83e-01 7.59e-01 0.17400 -1.74e-01 -0.001530 3.41e-01 9.93e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 603 1.42e-09 7.57e-08 0.17400 8.75e-02 0.150000 2.56e-04 3.67e-10
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 1.44e-03 1.23e-02 0.17400 6.01e-02 -0.163000 3.09e-01 5.85e-03
IRAK1 RECRUITS IKK COMPLEX 14 6.05e-01 7.69e-01 0.17400 8.07e-02 0.154000 6.01e-01 3.20e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 3.23e-01 5.50e-01 0.17300 1.11e-01 0.133000 2.54e-01 1.74e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 4.80e-01 6.89e-01 0.17300 -1.17e-01 -0.127000 3.30e-01 2.91e-01
PHOSPHORYLATION OF THE APC C 17 5.65e-01 7.52e-01 0.17300 1.44e-01 0.095300 3.03e-01 4.97e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 4.73e-03 3.08e-02 0.17300 6.49e-02 0.160000 1.86e-01 1.07e-03
SIGNALING BY THE B CELL RECEPTOR BCR 104 1.70e-02 8.32e-02 0.17300 6.03e-02 0.162000 2.88e-01 4.34e-03
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 1.50e-01 3.47e-01 0.17200 1.05e-01 0.136000 1.61e-01 7.09e-02
FGFR2 MUTANT RECEPTOR ACTIVATION 26 4.40e-01 6.63e-01 0.17200 1.27e-01 0.116000 2.61e-01 3.07e-01
PYRIMIDINE CATABOLISM 10 6.30e-01 7.87e-01 0.17200 2.71e-02 0.170000 8.82e-01 3.53e-01
SPHINGOLIPID METABOLISM 80 2.17e-02 9.81e-02 0.17200 1.96e-02 0.171000 7.62e-01 8.37e-03
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 1.84e-01 3.93e-01 0.17200 -1.25e-01 -0.118000 1.12e-01 1.35e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 106 1.73e-02 8.32e-02 0.17100 6.07e-02 0.160000 2.81e-01 4.40e-03
PLATELET HOMEOSTASIS 77 4.44e-02 1.62e-01 0.17100 -1.64e-01 -0.050200 1.31e-02 4.46e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 66 8.57e-02 2.44e-01 0.17100 6.54e-02 0.158000 3.58e-01 2.67e-02
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 33 1.61e-01 3.64e-01 0.17100 -1.24e-02 0.170000 9.02e-01 9.08e-02
MITOPHAGY 29 3.98e-01 6.21e-01 0.17000 1.01e-01 0.137000 3.44e-01 2.03e-01
PEPTIDE LIGAND BINDING RECEPTORS 117 2.32e-02 1.01e-01 0.17000 1.41e-01 0.094600 8.36e-03 7.72e-02
METABOLISM OF NUCLEOTIDES 92 5.71e-02 1.91e-01 0.17000 1.07e-01 0.132000 7.68e-02 2.84e-02
RECEPTOR MEDIATED MITOPHAGY 11 6.61e-01 8.08e-01 0.17000 -6.08e-02 -0.159000 7.27e-01 3.63e-01
PROTEIN UBIQUITINATION 70 1.23e-02 6.64e-02 0.17000 -4.72e-02 0.163000 4.95e-01 1.84e-02
REGULATION OF KIT SIGNALING 16 5.48e-01 7.41e-01 0.16900 -6.00e-02 -0.158000 6.78e-01 2.73e-01
SIGNALING BY FGFR2 63 1.17e-01 2.96e-01 0.16900 7.95e-02 0.150000 2.75e-01 4.02e-02
MITOTIC PROPHASE 95 3.59e-02 1.40e-01 0.16900 -7.26e-02 -0.153000 2.22e-01 1.01e-02
DISEASES OF GLYCOSYLATION 123 1.19e-02 6.47e-02 0.16900 1.56e-01 0.065700 2.91e-03 2.09e-01
METABOLISM OF FOLATE AND PTERINES 15 5.75e-01 7.55e-01 0.16900 1.57e-01 0.062000 2.93e-01 6.78e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 6.67e-01 8.10e-01 0.16800 1.00e-01 0.135000 5.31e-01 3.98e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 1.35e-01 3.26e-01 0.16800 -8.48e-03 0.168000 9.28e-01 7.35e-02
PYRUVATE METABOLISM 27 3.51e-01 5.75e-01 0.16800 -1.60e-01 -0.049800 1.50e-01 6.54e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 1.51e-01 3.48e-01 0.16800 -1.54e-01 0.065500 1.50e-01 5.42e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 5.86e-01 7.59e-01 0.16700 -1.17e-01 -0.119000 3.89e-01 3.82e-01
RHOV GTPASE CYCLE 32 3.85e-01 6.11e-01 0.16600 -1.04e-01 -0.130000 3.09e-01 2.05e-01
RAC3 GTPASE CYCLE 89 5.37e-03 3.39e-02 0.16500 -1.60e-01 0.042000 9.12e-03 4.94e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 3.90e-01 6.13e-01 0.16500 -1.28e-01 -0.105000 2.11e-01 3.05e-01
NRAGE SIGNALS DEATH THROUGH JNK 55 1.37e-01 3.28e-01 0.16500 -5.60e-02 -0.155000 4.73e-01 4.63e-02
CD209 DC SIGN SIGNALING 18 3.71e-01 5.98e-01 0.16500 -1.63e-01 0.026400 2.32e-01 8.46e-01
CILIUM ASSEMBLY 191 1.58e-05 3.03e-04 0.16500 1.59e-01 -0.042100 1.52e-04 3.17e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 5.94e-01 7.62e-01 0.16400 -1.60e-01 -0.034900 3.18e-01 8.28e-01
FRS MEDIATED FGFR3 SIGNALING 15 5.35e-01 7.30e-01 0.16400 2.71e-02 0.161000 8.56e-01 2.79e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 1.86e-01 3.95e-01 0.16400 -5.79e-02 -0.153000 4.88e-01 6.67e-02
RND1 GTPASE CYCLE 38 3.17e-01 5.43e-01 0.16400 -8.82e-02 -0.138000 3.47e-01 1.42e-01
RAC2 GTPASE CYCLE 87 1.19e-02 6.47e-02 0.16400 -1.63e-01 0.013000 8.61e-03 8.34e-01
INTERLEUKIN 17 SIGNALING 67 1.03e-01 2.73e-01 0.16300 -6.31e-02 -0.151000 3.72e-01 3.30e-02
FGFR2 LIGAND BINDING AND ACTIVATION 12 6.53e-01 8.02e-01 0.16300 5.41e-02 0.154000 7.46e-01 3.56e-01
PROCESSING OF SMDT1 16 6.19e-01 7.80e-01 0.16300 1.37e-01 0.088000 3.43e-01 5.42e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.95e-01 4.07e-01 0.16300 1.49e-01 0.064800 7.06e-02 4.32e-01
METABOLISM OF RNA 644 2.41e-08 1.18e-06 0.16300 1.09e-01 0.120000 2.35e-06 2.13e-07
FANCONI ANEMIA PATHWAY 36 1.41e-01 3.32e-01 0.16300 1.60e-01 -0.030200 9.72e-02 7.54e-01
NEUREXINS AND NEUROLIGINS 54 1.28e-01 3.16e-01 0.16200 -1.57e-01 -0.040500 4.55e-02 6.07e-01
RHO GTPASES ACTIVATE KTN1 11 5.64e-01 7.52e-01 0.16200 -2.00e-02 0.161000 9.08e-01 3.55e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 4.35e-01 6.59e-01 0.16200 -1.46e-01 -0.071000 1.98e-01 5.31e-01
SNRNP ASSEMBLY 51 1.28e-01 3.16e-01 0.16100 -2.73e-02 -0.159000 7.36e-01 4.98e-02
RND2 GTPASE CYCLE 38 2.86e-01 5.19e-01 0.16100 -6.19e-02 -0.148000 5.09e-01 1.13e-01
TRIGLYCERIDE CATABOLISM 14 4.11e-01 6.32e-01 0.16100 -8.70e-02 0.135000 5.73e-01 3.82e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 6.53e-01 8.02e-01 0.16000 1.60e-01 0.015500 3.82e-01 9.32e-01
METABOLISM OF COFACTORS 19 5.85e-01 7.59e-01 0.16000 9.50e-02 0.129000 4.73e-01 3.30e-01
DNA DAMAGE RECOGNITION IN GG NER 38 9.51e-02 2.60e-01 0.16000 1.37e-01 -0.081000 1.43e-01 3.88e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.82e-01 3.92e-01 0.16000 -9.19e-02 0.130000 4.09e-01 2.41e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 5.92e-01 7.61e-01 0.15900 9.68e-02 0.126000 4.65e-01 3.41e-01
S PHASE 153 6.12e-03 3.80e-02 0.15800 5.16e-02 0.149000 2.71e-01 1.45e-03
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 1.59e-01 3.60e-01 0.15800 1.21e-01 0.101000 8.28e-02 1.46e-01
RHOBTB GTPASE CYCLE 35 1.12e-01 2.87e-01 0.15800 -1.09e-01 0.113000 2.63e-01 2.45e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 2.76e-02 1.16e-01 0.15700 1.48e-01 -0.054500 4.11e-02 4.51e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 5.79e-01 7.57e-01 0.15700 2.27e-02 0.155000 8.83e-01 3.15e-01
INTERLEUKIN 12 FAMILY SIGNALING 44 1.24e-01 3.11e-01 0.15700 -1.42e-02 0.156000 8.71e-01 7.31e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 9.47e-02 2.60e-01 0.15500 -7.38e-02 -0.136000 2.46e-01 3.17e-02
GOLGI TO ER RETROGRADE TRANSPORT 119 4.53e-03 2.99e-02 0.15500 1.55e-01 -0.010600 3.57e-03 8.41e-01
CHROMOSOME MAINTENANCE 102 4.40e-02 1.62e-01 0.15500 5.82e-02 0.143000 3.10e-01 1.24e-02
SIALIC ACID METABOLISM 32 4.40e-01 6.63e-01 0.15500 -1.17e-01 -0.101000 2.51e-01 3.23e-01
SHC MEDIATED CASCADE FGFR3 13 5.85e-01 7.59e-01 0.15400 7.05e-03 0.154000 9.65e-01 3.35e-01
IRS MEDIATED SIGNALLING 39 3.73e-01 5.98e-01 0.15400 -1.16e-01 -0.101000 2.10e-01 2.75e-01
RAC1 GTPASE CYCLE 177 3.85e-03 2.61e-02 0.15400 -1.45e-01 -0.050200 8.78e-04 2.49e-01
INTERLEUKIN 35 SIGNALLING 10 7.39e-01 8.54e-01 0.15300 -5.76e-02 -0.142000 7.53e-01 4.36e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 2.21e-01 4.41e-01 0.15300 -1.37e-01 0.068900 2.18e-01 5.36e-01
PI 3K CASCADE FGFR2 16 5.27e-01 7.26e-01 0.15300 -1.53e-01 -0.008910 2.91e-01 9.51e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.38e-01 6.62e-01 0.15300 1.06e-01 -0.110000 4.91e-01 4.77e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 3.74e-01 5.98e-01 0.15200 -5.76e-02 -0.141000 5.67e-01 1.61e-01
METABOLISM OF CARBOHYDRATES 258 2.22e-05 4.00e-04 0.15200 1.52e-01 -0.002070 2.62e-05 9.54e-01
BILE ACID AND BILE SALT METABOLISM 24 3.04e-01 5.37e-01 0.15100 -3.95e-02 0.146000 7.38e-01 2.15e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 6.96e-01 8.29e-01 0.15000 -1.46e-01 -0.035800 4.01e-01 8.37e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 5.91e-01 7.61e-01 0.15000 1.38e-01 -0.059300 4.49e-01 7.45e-01
SEPARATION OF SISTER CHROMATIDS 166 1.45e-02 7.49e-02 0.15000 1.27e-01 0.080100 4.71e-03 7.54e-02
NUCLEAR SIGNALING BY ERBB4 31 4.23e-01 6.46e-01 0.15000 6.38e-02 0.136000 5.39e-01 1.91e-01
RHO GTPASES ACTIVATE PAKS 21 3.04e-01 5.37e-01 0.15000 -1.00e-01 0.111000 4.26e-01 3.77e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 5.70e-01 7.55e-01 0.15000 1.47e-01 -0.030700 3.79e-01 8.54e-01
NUCLEOBASE BIOSYNTHESIS 15 4.82e-01 6.92e-01 0.15000 3.98e-02 -0.144000 7.90e-01 3.33e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 3.07e-01 5.38e-01 0.14900 -1.71e-02 0.148000 8.78e-01 1.82e-01
INSULIN RECEPTOR SIGNALLING CASCADE 44 3.44e-01 5.68e-01 0.14900 -1.19e-01 -0.090100 1.73e-01 3.02e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 4.57e-01 6.77e-01 0.14900 1.43e-01 -0.043400 3.23e-01 7.64e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 178 1.31e-02 6.92e-02 0.14900 8.53e-02 0.122000 5.00e-02 5.04e-03
EXTENSION OF TELOMERES 49 3.16e-01 5.43e-01 0.14900 1.03e-01 0.108000 2.14e-01 1.93e-01
PROLACTIN RECEPTOR SIGNALING 11 6.40e-01 7.96e-01 0.14900 -4.27e-03 0.149000 9.80e-01 3.94e-01
SYNTHESIS OF PC 26 3.89e-01 6.13e-01 0.14800 1.51e-02 0.148000 8.94e-01 1.92e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 5.45e-01 7.39e-01 0.14800 -8.99e-02 0.118000 6.06e-01 4.98e-01
TRP CHANNELS 18 5.73e-01 7.55e-01 0.14800 -4.01e-02 -0.142000 7.68e-01 2.96e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 5.19e-01 7.23e-01 0.14700 -1.02e-01 0.106000 5.41e-01 5.24e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 3.76e-01 6.01e-01 0.14600 -1.46e-01 0.002990 2.05e-01 9.79e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 8.00e-02 2.34e-01 0.14600 -2.11e-02 -0.144000 7.52e-01 3.07e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 42 1.88e-01 3.98e-01 0.14600 1.46e-01 -0.007820 1.03e-01 9.30e-01
NGF STIMULATED TRANSCRIPTION 37 3.16e-01 5.43e-01 0.14600 -3.39e-02 -0.142000 7.21e-01 1.36e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 94 9.85e-02 2.65e-01 0.14600 -1.27e-01 -0.072500 3.41e-02 2.25e-01
SIGNALING BY EGFR IN CANCER 22 3.45e-01 5.68e-01 0.14500 -1.36e-01 0.052300 2.70e-01 6.71e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 1.32e-03 1.16e-02 0.14500 1.39e-01 -0.044500 4.41e-03 3.61e-01
INOSITOL PHOSPHATE METABOLISM 47 2.78e-01 5.14e-01 0.14500 -5.42e-02 -0.135000 5.20e-01 1.09e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 5.60e-01 7.50e-01 0.14500 -1.17e-01 0.085800 5.01e-01 6.22e-01
CRMPS IN SEMA3A SIGNALING 16 4.39e-01 6.63e-01 0.14500 7.43e-02 -0.125000 6.07e-01 3.88e-01
SIGNALING BY PDGF 57 8.03e-02 2.34e-01 0.14500 3.19e-02 -0.141000 6.77e-01 6.49e-02
PURINE SALVAGE 12 7.47e-01 8.59e-01 0.14500 1.25e-01 0.072000 4.52e-01 6.66e-01
SYNTHESIS OF PA 29 4.97e-01 7.04e-01 0.14400 1.25e-01 0.072200 2.45e-01 5.01e-01
FERTILIZATION 13 7.37e-01 8.53e-01 0.14400 -7.72e-02 -0.121000 6.30e-01 4.49e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.64e-01 3.69e-01 0.14300 3.01e-02 -0.140000 7.35e-01 1.16e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 4.61e-01 6.78e-01 0.14300 -1.36e-01 0.044200 3.31e-01 7.52e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 3.42e-01 5.67e-01 0.14300 -1.15e-01 0.085400 3.62e-01 4.98e-01
TBC RABGAPS 43 1.09e-01 2.81e-01 0.14300 1.02e-01 -0.100000 2.48e-01 2.56e-01
PTEN REGULATION 133 5.68e-02 1.91e-01 0.14300 1.01e-01 0.101000 4.42e-02 4.49e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX 107 6.88e-03 4.16e-02 0.14300 5.24e-02 -0.133000 3.49e-01 1.77e-02
EPIGENETIC REGULATION OF GENE EXPRESSION 104 5.29e-02 1.81e-01 0.14300 4.05e-02 0.137000 4.76e-01 1.61e-02
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 6.97e-01 8.29e-01 0.14200 -5.50e-02 -0.131000 7.21e-01 3.96e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 7.08e-01 8.34e-01 0.14200 9.30e-02 0.107000 5.20e-01 4.59e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 3.12e-01 5.43e-01 0.14100 1.22e-01 -0.070800 2.99e-01 5.48e-01
MICRORNA MIRNA BIOGENESIS 24 5.13e-01 7.20e-01 0.14100 1.35e-01 0.040900 2.51e-01 7.28e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 32 3.93e-01 6.14e-01 0.14100 1.37e-01 0.032300 1.79e-01 7.52e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 6.48e-01 7.99e-01 0.14100 7.28e-02 0.121000 5.83e-01 3.62e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 1.92e-01 4.03e-01 0.14100 -1.02e-01 0.097000 3.10e-01 3.35e-01
MITOTIC PROMETAPHASE 177 4.10e-03 2.73e-02 0.14000 -1.88e-02 -0.139000 6.67e-01 1.48e-03
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 4.64e-01 6.80e-01 0.14000 -3.88e-02 -0.134000 7.22e-01 2.19e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 7.66e-01 8.70e-01 0.13900 -1.19e-01 -0.072500 4.76e-01 6.64e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 1.49e-01 3.46e-01 0.13900 -1.32e-01 -0.042400 5.22e-02 5.34e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 5.21e-01 7.25e-01 0.13900 3.18e-02 0.135000 7.92e-01 2.62e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 3.37e-01 5.67e-01 0.13800 -1.36e-01 -0.019700 1.57e-01 8.38e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 25 5.14e-01 7.20e-01 0.13800 3.85e-02 0.132000 7.39e-01 2.52e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 5.34e-01 7.30e-01 0.13800 -5.33e-02 -0.127000 6.38e-01 2.63e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 17 5.13e-01 7.20e-01 0.13700 -1.34e-01 0.028200 3.38e-01 8.41e-01
ONCOGENE INDUCED SENESCENCE 32 4.55e-01 6.77e-01 0.13700 4.76e-02 0.128000 6.41e-01 2.10e-01
CIRCADIAN CLOCK 68 1.05e-01 2.76e-01 0.13600 -1.36e-01 0.000251 5.27e-02 9.97e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 6.83e-01 8.21e-01 0.13500 -1.35e-01 -0.005390 4.18e-01 9.74e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 1.70e-02 8.32e-02 0.13500 -9.35e-02 0.097300 1.28e-01 1.13e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 5.48e-01 7.41e-01 0.13500 -1.34e-01 0.013900 3.39e-01 9.21e-01
SUMOYLATION 164 4.29e-02 1.59e-01 0.13400 -1.01e-01 -0.088700 2.56e-02 5.03e-02
STIMULI SENSING CHANNELS 74 2.41e-01 4.72e-01 0.13400 -1.00e-01 -0.089600 1.37e-01 1.83e-01
PI 3K CASCADE FGFR4 12 6.29e-01 7.87e-01 0.13400 -1.30e-01 0.032900 4.36e-01 8.43e-01
BASE EXCISION REPAIR AP SITE FORMATION 30 3.58e-01 5.83e-01 0.13400 1.34e-01 -0.009860 2.05e-01 9.26e-01
SPRY REGULATION OF FGF SIGNALING 16 6.15e-01 7.77e-01 0.13400 1.33e-01 0.009090 3.55e-01 9.50e-01
GP1B IX V ACTIVATION SIGNALLING 10 7.66e-01 8.70e-01 0.13400 -2.84e-02 -0.131000 8.77e-01 4.75e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 22 6.53e-01 8.02e-01 0.13400 -1.05e-01 -0.082300 3.93e-01 5.04e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.31e-01 4.56e-01 0.13300 1.28e-01 0.037200 8.97e-02 6.21e-01
GPVI MEDIATED ACTIVATION CASCADE 31 2.53e-01 4.90e-01 0.13300 -9.53e-02 0.092100 3.58e-01 3.75e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 2.91e-01 5.27e-01 0.13200 6.80e-03 0.132000 9.40e-01 1.43e-01
RHO GTPASES ACTIVATE ROCKS 19 5.96e-01 7.63e-01 0.13200 2.04e-02 0.130000 8.77e-01 3.26e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 6.49e-02 2.06e-01 0.13100 -9.89e-02 0.086500 1.75e-01 2.35e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 5.29e-01 7.26e-01 0.13100 2.94e-02 0.128000 7.99e-01 2.68e-01
INFECTIOUS DISEASE 732 1.41e-07 6.14e-06 0.13100 4.68e-02 0.122000 3.21e-02 1.97e-08
SIGNALING BY ERBB2 48 1.55e-01 3.55e-01 0.13100 -1.23e-01 0.045100 1.41e-01 5.89e-01
G0 AND EARLY G1 24 5.05e-01 7.11e-01 0.13100 1.20e-02 0.130000 9.19e-01 2.69e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 1.77e-01 3.88e-01 0.13100 -6.43e-02 0.114000 4.71e-01 2.03e-01
SIGNALING BY KIT IN DISEASE 20 6.77e-01 8.17e-01 0.13100 -1.11e-01 -0.068500 3.90e-01 5.96e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 4.44e-01 6.68e-01 0.13000 -8.11e-02 0.102000 5.41e-01 4.41e-01
PI 3K CASCADE FGFR3 13 6.40e-01 7.96e-01 0.13000 -1.29e-01 0.019800 4.21e-01 9.01e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 4.90e-01 7.01e-01 0.13000 -6.97e-02 -0.110000 4.63e-01 2.46e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 1.50e-03 1.27e-02 0.12900 1.20e-01 -0.047100 6.62e-03 2.88e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 7.93e-01 8.86e-01 0.12900 -9.75e-02 -0.084600 5.43e-01 5.97e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 6.67e-01 8.10e-01 0.12900 -2.39e-02 -0.127000 8.69e-01 3.81e-01
RHOF GTPASE CYCLE 40 4.30e-01 6.53e-01 0.12900 -1.19e-01 -0.049600 1.94e-01 5.87e-01
VXPX CARGO TARGETING TO CILIUM 19 4.60e-01 6.78e-01 0.12900 1.07e-01 -0.071600 4.20e-01 5.89e-01
BASIGIN INTERACTIONS 22 6.49e-01 7.99e-01 0.12800 -5.93e-02 -0.114000 6.30e-01 3.56e-01
REPRODUCTION 76 2.65e-01 5.04e-01 0.12800 -9.55e-02 -0.085300 1.50e-01 1.99e-01
MITOTIC METAPHASE AND ANAPHASE 207 2.25e-02 1.00e-01 0.12800 1.08e-01 0.068200 7.48e-03 9.12e-02
CALNEXIN CALRETICULIN CYCLE 26 6.26e-01 7.84e-01 0.12800 7.36e-02 0.104000 5.16e-01 3.57e-01
HATS ACETYLATE HISTONES 93 6.46e-02 2.05e-01 0.12800 2.07e-03 -0.127000 9.72e-01 3.37e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 7.82e-01 8.78e-01 0.12700 8.05e-02 0.098700 6.02e-01 5.23e-01
REGULATION OF FZD BY UBIQUITINATION 20 6.54e-01 8.02e-01 0.12600 1.19e-01 0.041800 3.57e-01 7.46e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 2.57e-01 4.93e-01 0.12600 -9.25e-02 0.085400 3.50e-01 3.89e-01
MEIOSIS 63 3.39e-01 5.67e-01 0.12600 -9.91e-02 -0.077700 1.74e-01 2.86e-01
CELL JUNCTION ORGANIZATION 73 2.66e-01 5.04e-01 0.12600 -1.08e-01 -0.064900 1.11e-01 3.38e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.15e-01 7.20e-01 0.12600 3.74e-02 -0.120000 7.78e-01 3.65e-01
SIGNALING BY FGFR 74 2.00e-01 4.15e-01 0.12600 3.71e-02 0.120000 5.82e-01 7.45e-02
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 45 3.82e-01 6.07e-01 0.12500 -3.83e-02 -0.119000 6.57e-01 1.67e-01
SIGNALING BY ERBB4 57 1.07e-01 2.78e-01 0.12500 -8.97e-02 0.086800 2.42e-01 2.57e-01
RHOB GTPASE CYCLE 67 3.32e-01 5.61e-01 0.12500 -8.77e-02 -0.088300 2.14e-01 2.11e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 2.69e-01 5.06e-01 0.12400 -3.93e-02 0.118000 6.75e-01 2.08e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 52 1.82e-01 3.92e-01 0.12400 1.21e-01 -0.029200 1.32e-01 7.15e-01
RHOBTB2 GTPASE CYCLE 23 4.21e-01 6.44e-01 0.12400 -6.35e-02 0.107000 5.98e-01 3.76e-01
LYSOSOME VESICLE BIOGENESIS 32 2.93e-01 5.27e-01 0.12400 7.74e-02 -0.096400 4.49e-01 3.45e-01
GAP JUNCTION DEGRADATION 11 7.45e-01 8.59e-01 0.12400 3.31e-03 0.123000 9.85e-01 4.78e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 4.99e-01 7.06e-01 0.12300 -5.78e-02 0.109000 6.63e-01 4.11e-01
G2 M CHECKPOINTS 133 9.11e-02 2.53e-01 0.12300 5.77e-02 0.109000 2.51e-01 3.01e-02
KILLING MECHANISMS 10 8.00e-01 8.92e-01 0.12300 1.20e-01 0.026600 5.13e-01 8.84e-01
HCMV EARLY EVENTS 81 4.83e-02 1.69e-01 0.12200 7.66e-02 -0.095300 2.33e-01 1.38e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 7.48e-01 8.60e-01 0.12200 -4.49e-02 -0.114000 7.64e-01 4.46e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 1.55e-01 3.55e-01 0.12200 -4.10e-02 -0.115000 4.93e-01 5.40e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 6.44e-01 7.99e-01 0.12200 1.21e-01 -0.014200 4.16e-01 9.24e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 5.71e-01 7.55e-01 0.12200 1.24e-02 0.121000 9.18e-01 3.16e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 6.98e-01 8.29e-01 0.12100 -1.19e-01 -0.022600 4.09e-01 8.76e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 178 3.88e-02 1.47e-01 0.12100 4.74e-02 0.111000 2.75e-01 1.08e-02
SIGNALLING TO ERKS 33 5.75e-01 7.55e-01 0.12000 -6.01e-02 -0.104000 5.50e-01 3.01e-01
COSTIMULATION BY THE CD28 FAMILY 50 2.56e-01 4.92e-01 0.12000 -1.20e-01 0.008260 1.43e-01 9.20e-01
MHC CLASS II ANTIGEN PRESENTATION 102 4.48e-02 1.62e-01 0.12000 1.17e-01 -0.028100 4.21e-02 6.24e-01
MAP2K AND MAPK ACTIVATION 36 2.86e-01 5.19e-01 0.12000 -5.90e-02 0.104000 5.40e-01 2.79e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 22 5.92e-01 7.61e-01 0.12000 -1.19e-01 -0.011400 3.33e-01 9.27e-01
GENE SILENCING BY RNA 83 1.71e-01 3.78e-01 0.11900 -2.50e-02 -0.117000 6.93e-01 6.59e-02
LAMININ INTERACTIONS 29 6.03e-01 7.68e-01 0.11900 -1.08e-01 -0.051900 3.16e-01 6.28e-01
EPHB MEDIATED FORWARD SIGNALING 42 2.60e-01 4.98e-01 0.11900 -1.11e-01 0.042200 2.14e-01 6.36e-01
MRNA SPLICING 188 5.09e-02 1.75e-01 0.11800 1.01e-01 0.062500 1.75e-02 1.40e-01
SARS COV 2 INFECTION 65 3.56e-01 5.82e-01 0.11800 6.27e-02 0.100000 3.82e-01 1.62e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 1.23e-01 3.08e-01 0.11800 -1.16e-01 -0.019400 4.76e-02 7.42e-01
G ALPHA Z SIGNALLING EVENTS 45 2.06e-01 4.23e-01 0.11800 -8.36e-02 0.083100 3.32e-01 3.35e-01
APOPTOTIC EXECUTION PHASE 45 2.80e-01 5.15e-01 0.11700 -1.15e-01 0.021500 1.81e-01 8.03e-01
SYNDECAN INTERACTIONS 27 6.25e-01 7.84e-01 0.11700 4.55e-02 0.108000 6.82e-01 3.33e-01
VISUAL PHOTOTRANSDUCTION 62 4.03e-01 6.24e-01 0.11700 9.00e-02 0.074500 2.20e-01 3.11e-01
SIGNALING BY NOTCH 188 5.79e-02 1.93e-01 0.11600 6.15e-02 0.098300 1.46e-01 2.02e-02
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.85e-01 5.19e-01 0.11600 1.16e-01 0.001290 1.46e-01 9.87e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 4.54e-01 6.77e-01 0.11500 6.10e-02 0.098000 4.47e-01 2.22e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 61 3.05e-01 5.37e-01 0.11500 -1.12e-01 -0.026600 1.30e-01 7.19e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 7.87e-01 8.83e-01 0.11500 8.27e-02 0.079800 5.55e-01 5.69e-01
FATTY ACYL COA BIOSYNTHESIS 32 3.62e-01 5.87e-01 0.11500 -1.01e-01 0.055200 3.25e-01 5.89e-01
PI 3K CASCADE FGFR1 15 7.76e-01 8.76e-01 0.11500 -1.06e-01 -0.043600 4.77e-01 7.70e-01
CELLULAR RESPONSE TO HEAT STRESS 94 8.75e-02 2.48e-01 0.11500 1.48e-02 -0.114000 8.04e-01 5.71e-02
DOWNSTREAM SIGNAL TRANSDUCTION 29 5.67e-01 7.52e-01 0.11500 -2.45e-02 -0.112000 8.20e-01 2.97e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 2.66e-01 5.04e-01 0.11500 -3.37e-02 -0.110000 6.19e-01 1.06e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 8.55e-01 9.24e-01 0.11500 -1.02e-01 -0.052700 5.78e-01 7.73e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 5.36e-01 7.30e-01 0.11400 -1.12e-01 -0.024400 2.74e-01 8.11e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 5.27e-01 7.26e-01 0.11400 -6.07e-02 0.096800 6.38e-01 4.54e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 7.46e-01 8.59e-01 0.11400 -1.07e-01 -0.039100 4.44e-01 7.80e-01
FRS MEDIATED FGFR2 SIGNALING 18 6.19e-01 7.80e-01 0.11400 -1.99e-02 0.112000 8.84e-01 4.10e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 5.02e-01 7.09e-01 0.11300 1.73e-02 0.112000 8.61e-01 2.58e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 6.90e-01 8.25e-01 0.11300 1.11e-01 0.022000 4.01e-01 8.68e-01
DISEASES OF PROGRAMMED CELL DEATH 55 4.58e-01 6.78e-01 0.11300 9.25e-02 0.065500 2.36e-01 4.01e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.88e-01 8.24e-01 0.11300 -3.68e-02 0.107000 8.18e-01 5.04e-01
INNATE IMMUNE SYSTEM 778 1.54e-07 6.25e-06 0.11300 1.15e-02 0.113000 5.87e-01 1.08e-07
O LINKED GLYCOSYLATION 83 1.28e-01 3.16e-01 0.11200 1.31e-02 -0.112000 8.37e-01 7.88e-02
MRNA CAPPING 29 6.69e-01 8.11e-01 0.11200 6.66e-02 0.090400 5.35e-01 3.99e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 5.85e-01 7.59e-01 0.11200 -1.06e-01 0.035900 4.22e-01 7.87e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 44 5.25e-01 7.26e-01 0.11200 -9.75e-02 -0.055100 2.63e-01 5.27e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 5.98e-01 7.65e-01 0.11200 2.96e-02 0.108000 7.83e-01 3.16e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.10e-01 6.30e-01 0.11100 -1.11e-01 -0.009210 2.08e-01 9.17e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 6.07e-01 7.71e-01 0.11100 1.02e-01 0.044600 3.18e-01 6.63e-01
SIGNALING BY WNT IN CANCER 31 6.32e-01 7.88e-01 0.11100 -4.97e-02 -0.098900 6.32e-01 3.41e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 7.13e-01 8.38e-01 0.11000 -1.07e-01 0.026200 5.03e-01 8.70e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 28 4.71e-01 6.83e-01 0.11000 -3.33e-02 0.105000 7.61e-01 3.36e-01
NONHOMOLOGOUS END JOINING NHEJ 44 5.62e-01 7.51e-01 0.11000 -6.88e-02 -0.085900 4.30e-01 3.24e-01
SARS COV 1 INFECTION 48 5.29e-01 7.26e-01 0.11000 6.51e-02 0.088700 4.35e-01 2.88e-01
BASE EXCISION REPAIR 57 2.95e-01 5.29e-01 0.11000 1.10e-01 0.001010 1.52e-01 9.89e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 7.34e-01 8.51e-01 0.11000 2.66e-02 -0.106000 8.73e-01 5.23e-01
RHOD GTPASE CYCLE 50 4.96e-01 7.04e-01 0.11000 -9.55e-02 -0.054000 2.43e-01 5.09e-01
MEIOTIC RECOMBINATION 38 3.91e-01 6.13e-01 0.11000 -1.08e-01 0.020500 2.51e-01 8.27e-01
INTRA GOLGI TRAFFIC 43 4.71e-01 6.83e-01 0.10900 -2.49e-02 -0.106000 7.78e-01 2.28e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 5.05e-01 7.11e-01 0.10900 -8.61e-02 0.066700 4.75e-01 5.80e-01
ENDOGENOUS STEROLS 21 6.93e-01 8.26e-01 0.10900 2.42e-02 0.106000 8.48e-01 4.00e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 90 3.17e-01 5.43e-01 0.10900 -6.71e-02 -0.085500 2.72e-01 1.61e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 6.02e-01 7.68e-01 0.10900 -1.03e-01 -0.035200 3.15e-01 7.30e-01
HOST INTERACTIONS OF HIV FACTORS 124 2.14e-01 4.36e-01 0.10800 7.43e-02 0.078800 1.54e-01 1.30e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 7.99e-01 8.92e-01 0.10800 -1.00e-01 -0.041100 5.02e-01 7.83e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 197 5.49e-02 1.86e-01 0.10800 4.18e-02 0.099700 3.12e-01 1.60e-02
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 2.67e-01 5.04e-01 0.10800 7.71e-02 0.075600 1.68e-01 1.77e-01
CELL CELL COMMUNICATION 106 2.01e-01 4.16e-01 0.10800 -1.01e-01 -0.038500 7.34e-02 4.94e-01
L1CAM INTERACTIONS 109 1.27e-01 3.16e-01 0.10800 -1.20e-02 -0.107000 8.29e-01 5.34e-02
MITOTIC G2 G2 M PHASES 184 1.73e-02 8.32e-02 0.10800 1.07e-01 -0.009340 1.22e-02 8.27e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 3.00e-03 2.13e-02 0.10700 1.07e-01 -0.000297 1.87e-03 9.93e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 7.19e-01 8.43e-01 0.10700 6.28e-02 0.086900 5.79e-01 4.43e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 69 1.39e-01 3.30e-01 0.10700 -8.37e-02 0.066600 2.30e-01 3.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 4.30e-01 6.53e-01 0.10600 6.40e-02 -0.084800 5.44e-01 4.22e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 9.63e-02 2.61e-01 0.10600 8.00e-03 0.106000 8.78e-01 4.20e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 8.83e-01 9.40e-01 0.10500 -8.73e-02 -0.059000 6.33e-01 7.47e-01
SENSORY PROCESSING OF SOUND 62 2.10e-01 4.30e-01 0.10500 3.90e-02 -0.097200 5.96e-01 1.86e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 8.14e-01 9.04e-01 0.10400 1.01e-01 0.025700 5.27e-01 8.72e-01
SIGNALING BY ACTIVIN 12 8.56e-01 9.25e-01 0.10400 -9.19e-02 -0.049500 5.81e-01 7.67e-01
TRIGLYCERIDE METABOLISM 24 5.72e-01 7.55e-01 0.10400 -2.51e-02 0.101000 8.31e-01 3.90e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 8.33e-01 9.15e-01 0.10400 9.68e-02 0.038900 5.45e-01 8.08e-01
METABOLISM OF VITAMINS AND COFACTORS 156 1.47e-01 3.42e-01 0.10400 8.86e-02 0.054900 5.64e-02 2.37e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 1.93e-01 4.03e-01 0.10400 9.80e-03 -0.104000 8.80e-01 1.12e-01
IRON UPTAKE AND TRANSPORT 51 5.33e-01 7.30e-01 0.10400 5.41e-02 0.088700 5.04e-01 2.73e-01
HIV TRANSCRIPTION ELONGATION 42 5.21e-01 7.25e-01 0.10400 1.00e-01 0.025200 2.60e-01 7.78e-01
CELLULAR HEXOSE TRANSPORT 11 8.49e-01 9.22e-01 0.10300 9.91e-02 0.029300 5.69e-01 8.67e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 6.47e-01 7.99e-01 0.10300 9.38e-02 0.041400 3.51e-01 6.80e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 6.65e-01 8.10e-01 0.10300 1.02e-01 0.007760 3.96e-01 9.49e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 22 7.32e-01 8.51e-01 0.10200 3.17e-02 0.096900 7.97e-01 4.31e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 62 3.42e-01 5.67e-01 0.10200 -8.51e-03 -0.101000 9.08e-01 1.67e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 5.59e-01 7.50e-01 0.10200 -6.34e-02 -0.079500 4.29e-01 3.21e-01
ESR MEDIATED SIGNALING 167 1.71e-02 8.32e-02 0.10100 -9.05e-02 0.045900 4.38e-02 3.07e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 20 5.95e-01 7.62e-01 0.10100 6.99e-02 -0.073600 5.89e-01 5.69e-01
TRNA PROCESSING 105 1.41e-01 3.32e-01 0.10100 2.59e-03 -0.101000 9.63e-01 7.35e-02
RHOG GTPASE CYCLE 73 1.98e-01 4.12e-01 0.10100 -9.75e-02 0.027200 1.50e-01 6.88e-01
ION TRANSPORT BY P TYPE ATPASES 49 5.17e-01 7.22e-01 0.10100 -9.48e-02 -0.034600 2.51e-01 6.76e-01
DNA STRAND ELONGATION 32 7.07e-01 8.34e-01 0.10100 7.32e-02 0.069400 4.73e-01 4.97e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 75 2.22e-01 4.42e-01 0.10100 -1.34e-02 0.099700 8.41e-01 1.36e-01
STRIATED MUSCLE CONTRACTION 25 5.57e-01 7.49e-01 0.09990 -4.11e-02 0.091000 7.22e-01 4.31e-01
GABA B RECEPTOR ACTIVATION 39 5.83e-01 7.59e-01 0.09960 -9.54e-02 -0.028400 3.02e-01 7.59e-01
MITOCHONDRIAL BIOGENESIS 92 1.05e-01 2.75e-01 0.09910 -6.25e-02 0.076900 3.00e-01 2.03e-01
CD28 CO STIMULATION 31 4.79e-01 6.89e-01 0.09900 -8.61e-02 0.049000 4.07e-01 6.37e-01
PYROPTOSIS 21 6.63e-01 8.10e-01 0.09880 -1.40e-02 0.097800 9.12e-01 4.38e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 4.49e-01 6.74e-01 0.09870 9.84e-02 -0.007930 2.64e-01 9.28e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 4.55e-01 6.77e-01 0.09870 9.51e-02 0.026300 2.14e-01 7.32e-01
SIGNALING BY NODAL 15 8.24e-01 9.09e-01 0.09840 -9.27e-02 -0.033100 5.34e-01 8.24e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 7.89e-01 8.83e-01 0.09830 8.87e-02 0.042400 4.93e-01 7.43e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 8.65e-01 9.30e-01 0.09800 -9.60e-02 -0.019500 5.99e-01 9.15e-01
G ALPHA I SIGNALLING EVENTS 205 7.45e-02 2.24e-01 0.09760 -9.22e-02 -0.031900 2.30e-02 4.32e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 9.04e-01 9.49e-01 0.09710 -7.11e-02 -0.066100 6.97e-01 7.17e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.32e-01 8.51e-01 0.09640 -4.45e-02 0.085500 7.73e-01 5.80e-01
P38MAPK EVENTS 12 7.55e-01 8.65e-01 0.09640 7.22e-02 -0.063900 6.65e-01 7.02e-01
APOPTOSIS 163 1.60e-01 3.62e-01 0.09570 4.02e-02 0.086800 3.77e-01 5.61e-02
DEADENYLATION DEPENDENT MRNA DECAY 55 5.63e-01 7.52e-01 0.09400 -8.27e-02 -0.044700 2.89e-01 5.66e-01
ACYL CHAIN REMODELLING OF PS 14 8.60e-01 9.27e-01 0.09380 4.06e-02 0.084600 7.93e-01 5.84e-01
NEDDYLATION 219 1.30e-01 3.18e-01 0.09360 7.18e-02 0.060100 6.73e-02 1.26e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 4.47e-01 6.71e-01 0.09340 -3.06e-02 -0.088200 6.61e-01 2.05e-01
FRS MEDIATED FGFR1 SIGNALING 17 8.17e-01 9.05e-01 0.09330 2.89e-02 0.088800 8.37e-01 5.26e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 20 8.21e-01 9.08e-01 0.09330 7.86e-02 0.050200 5.43e-01 6.97e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.75e-01 9.37e-01 0.09300 9.15e-02 0.016300 6.16e-01 9.29e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 6.16e-01 7.77e-01 0.09290 9.18e-02 -0.013800 4.00e-01 8.99e-01
UNWINDING OF DNA 12 8.94e-01 9.45e-01 0.09260 -7.34e-02 -0.056300 6.60e-01 7.36e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 7.26e-01 8.48e-01 0.09250 9.19e-02 0.010900 4.46e-01 9.28e-01
SIGNALING BY PTK6 50 4.23e-01 6.46e-01 0.09210 -1.49e-02 0.090900 8.56e-01 2.66e-01
SIGNALING BY WNT 268 3.18e-02 1.29e-01 0.09210 1.65e-02 0.090600 6.43e-01 1.08e-02
METABOLISM OF STEROIDS 114 3.13e-01 5.43e-01 0.09160 8.24e-02 0.040000 1.29e-01 4.61e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 6.88e-01 8.24e-01 0.09110 3.39e-02 0.084500 7.28e-01 3.87e-01
HCMV INFECTION 104 1.45e-01 3.39e-01 0.09080 8.53e-02 -0.030900 1.33e-01 5.87e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 8.91e-01 9.43e-01 0.09060 6.95e-02 0.058100 6.64e-01 7.17e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 9.08e-01 9.49e-01 0.09060 6.88e-02 0.058900 6.93e-01 7.35e-01
CDC42 GTPASE CYCLE 152 2.70e-01 5.06e-01 0.09030 -6.43e-02 -0.063300 1.71e-01 1.78e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 1.45e-01 3.39e-01 0.09010 3.68e-02 -0.082300 5.21e-01 1.51e-01
CHROMATIN MODIFYING ENZYMES 219 6.18e-02 2.01e-01 0.09010 -1.32e-02 -0.089100 7.36e-01 2.32e-02
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 6.26e-01 7.84e-01 0.08980 6.42e-02 -0.062800 5.94e-01 6.02e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 47 6.65e-01 8.10e-01 0.08950 5.55e-02 0.070200 5.10e-01 4.05e-01
G2 M DNA DAMAGE CHECKPOINT 66 5.15e-01 7.20e-01 0.08940 -8.20e-02 -0.035600 2.49e-01 6.17e-01
SIGNALING BY NTRK3 TRKC 17 8.07e-01 8.98e-01 0.08940 -1.33e-02 -0.088400 9.24e-01 5.28e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 3.72e-02 1.44e-01 0.08940 8.44e-02 -0.029400 4.80e-02 4.91e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 8.00e-01 8.92e-01 0.08930 8.56e-02 0.025200 5.07e-01 8.46e-01
MTORC1 MEDIATED SIGNALLING 24 6.87e-01 8.24e-01 0.08920 -1.03e-02 0.088600 9.30e-01 4.53e-01
GPCR LIGAND BINDING 278 8.78e-02 2.48e-01 0.08910 4.99e-02 0.073900 1.53e-01 3.43e-02
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 6.73e-01 8.13e-01 0.08850 8.48e-02 -0.025400 4.81e-01 8.33e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 9.08e-01 9.49e-01 0.08850 4.87e-02 0.073900 7.80e-01 6.71e-01
METALLOPROTEASE DUBS 26 7.29e-01 8.49e-01 0.08780 1.34e-02 0.086800 9.06e-01 4.44e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 7.35e-01 8.51e-01 0.08770 3.74e-02 -0.079300 7.90e-01 5.71e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 283 1.93e-02 9.04e-02 0.08750 8.74e-02 -0.003280 1.15e-02 9.25e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 118 1.32e-01 3.22e-01 0.08680 3.13e-02 -0.081000 5.57e-01 1.29e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 3.87e-01 6.13e-01 0.08680 8.63e-02 0.009210 1.90e-01 8.89e-01
RUNX2 REGULATES BONE DEVELOPMENT 28 5.92e-01 7.61e-01 0.08660 -5.22e-02 0.069100 6.33e-01 5.27e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 92 4.53e-01 6.77e-01 0.08630 4.36e-02 0.074600 4.71e-01 2.17e-01
RNA POLYMERASE III TRANSCRIPTION 41 5.54e-01 7.47e-01 0.08630 8.59e-02 -0.008260 3.41e-01 9.27e-01
INSULIN RECEPTOR RECYCLING 20 8.48e-01 9.22e-01 0.08620 7.09e-02 0.049000 5.83e-01 7.05e-01
INTERLEUKIN 27 SIGNALING 10 9.05e-01 9.49e-01 0.08610 -8.14e-02 -0.028100 6.56e-01 8.78e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 6.46e-01 7.99e-01 0.08580 8.01e-02 -0.030800 4.80e-01 7.86e-01
RESOLUTION OF ABASIC SITES AP SITES 37 5.25e-01 7.26e-01 0.08570 7.72e-02 -0.037300 4.17e-01 6.94e-01
SIGNALING BY INTERLEUKINS 344 1.84e-02 8.71e-02 0.08560 1.06e-02 0.084900 7.37e-01 6.92e-03
SIGNALING BY SCF KIT 41 5.35e-01 7.30e-01 0.08560 -8.38e-02 0.017300 3.53e-01 8.48e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 4.41e-02 1.62e-01 0.08560 -8.15e-03 0.085200 8.34e-01 2.86e-02
RHO GTPASE CYCLE 425 3.58e-02 1.40e-01 0.08540 -6.90e-02 -0.050300 1.49e-02 7.64e-02
SIGNAL TRANSDUCTION BY L1 21 8.46e-01 9.22e-01 0.08520 -6.84e-02 -0.050900 5.87e-01 6.87e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 6.67e-01 8.10e-01 0.08520 -5.09e-02 -0.068300 5.29e-01 3.99e-01
INTERLEUKIN 37 SIGNALING 18 8.70e-01 9.34e-01 0.08470 6.50e-02 0.054200 6.33e-01 6.90e-01
NEGATIVE REGULATION OF FLT3 14 8.87e-01 9.41e-01 0.08430 7.53e-02 0.037800 6.26e-01 8.06e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 5.00e-01 7.06e-01 0.08420 -8.11e-02 0.022800 3.47e-01 7.91e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 3.42e-01 5.67e-01 0.08410 -8.09e-02 -0.022900 1.46e-01 6.81e-01
PEPTIDE HORMONE METABOLISM 59 3.57e-01 5.82e-01 0.08400 -4.82e-02 0.068700 5.22e-01 3.61e-01
SIGNALING BY FGFR1 43 6.65e-01 8.10e-01 0.08390 -7.94e-02 -0.027100 3.68e-01 7.58e-01
EXTRACELLULAR MATRIX ORGANIZATION 243 1.57e-01 3.57e-01 0.08380 6.76e-02 0.049600 7.00e-02 1.84e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 539 1.12e-04 1.56e-03 0.08370 -6.82e-02 0.048500 6.97e-03 5.51e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 7.51e-01 8.62e-01 0.08340 8.32e-02 0.004710 4.80e-01 9.68e-01
HIV TRANSCRIPTION INITIATION 45 5.82e-01 7.59e-01 0.08330 3.41e-03 0.083200 9.68e-01 3.34e-01
SIGNALING BY NUCLEAR RECEPTORS 223 2.17e-02 9.81e-02 0.08300 -5.72e-02 0.060100 1.42e-01 1.23e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 7.10e-01 8.36e-01 0.08290 4.46e-02 0.069800 6.08e-01 4.23e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 49 4.77e-01 6.89e-01 0.08250 2.54e-02 -0.078600 7.59e-01 3.42e-01
RNA POLYMERASE II TRANSCRIPTION 1087 5.56e-05 8.95e-04 0.08250 -7.94e-02 -0.022400 1.16e-05 2.17e-01
SIGNALING BY RETINOIC ACID 32 7.82e-01 8.78e-01 0.08220 4.35e-02 0.069800 6.71e-01 4.95e-01
ECM PROTEOGLYCANS 67 5.67e-01 7.52e-01 0.08200 3.24e-02 0.075300 6.47e-01 2.87e-01
HCMV LATE EVENTS 66 5.28e-01 7.26e-01 0.08200 -2.02e-02 -0.079400 7.77e-01 2.65e-01
TRIGLYCERIDE BIOSYNTHESIS 10 9.31e-01 9.61e-01 0.08190 6.15e-02 0.054100 7.36e-01 7.67e-01
REGULATION OF BACH1 ACTIVITY 11 8.74e-01 9.37e-01 0.08170 2.05e-03 -0.081700 9.91e-01 6.39e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 6.46e-01 7.99e-01 0.08130 -5.97e-02 -0.055200 4.16e-01 4.52e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 7.04e-01 8.31e-01 0.08080 7.17e-02 0.037300 4.06e-01 6.65e-01
FLT3 SIGNALING 36 7.33e-01 8.51e-01 0.08060 -7.59e-02 -0.027000 4.31e-01 7.79e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.36e-01 9.16e-01 0.08000 -3.17e-02 0.073400 8.49e-01 6.60e-01
ION CHANNEL TRANSPORT 140 3.92e-01 6.14e-01 0.07950 -5.74e-02 -0.055000 2.42e-01 2.61e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 3.17e-01 5.43e-01 0.07930 -4.55e-02 0.064900 4.99e-01 3.34e-01
SIGNALING BY EGFR 47 4.79e-01 6.89e-01 0.07920 -6.34e-02 0.047500 4.52e-01 5.73e-01
RHOBTB3 ATPASE CYCLE 10 8.86e-01 9.41e-01 0.07900 7.40e-03 -0.078600 9.68e-01 6.67e-01
PKMTS METHYLATE HISTONE LYSINES 49 6.98e-01 8.29e-01 0.07860 -6.95e-02 -0.036700 4.00e-01 6.57e-01
METABOLISM OF LIPIDS 613 2.90e-03 2.11e-02 0.07790 9.05e-03 0.077400 7.03e-01 1.12e-03
CTLA4 INHIBITORY SIGNALING 20 7.62e-01 8.67e-01 0.07790 2.51e-02 -0.073800 8.46e-01 5.68e-01
NICOTINATE METABOLISM 25 7.03e-01 8.31e-01 0.07740 -7.02e-02 0.032500 5.43e-01 7.79e-01
HIV INFECTION 220 2.44e-01 4.76e-01 0.07740 6.06e-02 0.048000 1.22e-01 2.20e-01
AQUAPORIN MEDIATED TRANSPORT 39 6.59e-01 8.07e-01 0.07710 -7.71e-02 0.000253 4.05e-01 9.98e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 7.88e-01 8.83e-01 0.07710 -2.85e-02 -0.071600 7.84e-01 4.90e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 8.38e-01 9.17e-01 0.07710 -4.36e-02 0.063500 7.94e-01 7.03e-01
PI3K AKT SIGNALING IN CANCER 88 4.57e-01 6.77e-01 0.07640 -7.51e-02 -0.014000 2.24e-01 8.20e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 86 3.99e-01 6.21e-01 0.07590 -7.58e-02 0.003510 2.24e-01 9.55e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 8.17e-01 9.05e-01 0.07570 5.81e-02 -0.048600 7.07e-01 7.53e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 93 5.67e-01 7.52e-01 0.07560 -4.96e-02 -0.057000 4.09e-01 3.42e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 8.10e-01 9.00e-01 0.07540 -2.60e-02 -0.070800 8.12e-01 5.17e-01
MITOTIC SPINDLE CHECKPOINT 97 4.03e-01 6.24e-01 0.07520 -6.65e-03 -0.074900 9.10e-01 2.03e-01
HIV LIFE CYCLE 142 2.21e-01 4.41e-01 0.07450 6.83e-03 -0.074200 8.88e-01 1.27e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 4.16e-01 6.38e-01 0.07410 4.33e-02 0.060100 3.67e-01 2.10e-01
EGFR DOWNREGULATION 28 6.99e-01 8.29e-01 0.07400 -6.79e-02 0.029500 5.34e-01 7.87e-01
SHC MEDIATED CASCADE FGFR1 15 8.80e-01 9.40e-01 0.07390 1.18e-02 0.073000 9.37e-01 6.25e-01
PROGRAMMED CELL DEATH 185 3.30e-01 5.59e-01 0.07360 4.15e-02 0.060800 3.31e-01 1.54e-01
LEISHMANIA INFECTION 197 7.30e-02 2.22e-01 0.07340 -5.95e-02 0.043100 1.51e-01 2.98e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 6.45e-01 7.99e-01 0.07320 6.87e-02 0.025400 3.50e-01 7.30e-01
RAF ACTIVATION 34 7.78e-01 8.76e-01 0.07270 -2.08e-02 -0.069700 8.34e-01 4.82e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 9.20e-01 9.57e-01 0.07240 5.20e-02 0.050300 7.27e-01 7.36e-01
HOMOLOGY DIRECTED REPAIR 107 5.52e-01 7.45e-01 0.07230 -5.29e-02 -0.049300 3.45e-01 3.79e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 6.78e-01 8.17e-01 0.07220 -4.18e-02 0.058800 6.92e-01 5.77e-01
SIGNALING BY FGFR2 IN DISEASE 36 6.83e-01 8.21e-01 0.07220 -1.21e-02 0.071100 9.00e-01 4.60e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 36 6.26e-01 7.84e-01 0.07180 -5.10e-02 0.050600 5.97e-01 6.00e-01
RHO GTPASES ACTIVATE FORMINS 119 2.53e-01 4.90e-01 0.07150 2.49e-02 -0.067100 6.40e-01 2.07e-01
DNA DAMAGE BYPASS 46 7.08e-01 8.34e-01 0.07130 -6.95e-02 -0.015900 4.15e-01 8.52e-01
RHO GTPASES ACTIVATE PKNS 48 5.76e-01 7.55e-01 0.07070 -2.64e-02 0.065600 7.51e-01 4.32e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 6.31e-01 7.88e-01 0.07040 -6.00e-02 0.036900 5.23e-01 6.94e-01
SARS COV INFECTIONS 140 4.66e-01 6.80e-01 0.07040 5.76e-02 0.040400 2.40e-01 4.09e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 9.16e-01 9.54e-01 0.07020 -1.52e-02 -0.068500 9.27e-01 6.81e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 3.88e-01 6.13e-01 0.06980 -1.66e-02 -0.067800 7.40e-01 1.76e-01
DUAL INCISION IN TC NER 64 7.21e-01 8.43e-01 0.06920 4.53e-02 0.052300 5.31e-01 4.70e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 6.16e-01 7.77e-01 0.06910 -6.12e-03 -0.068800 9.34e-01 3.53e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 6.11e-01 7.74e-01 0.06910 -5.05e-02 0.047100 5.76e-01 6.02e-01
TOLL LIKE RECEPTOR CASCADES 137 2.68e-01 5.04e-01 0.06870 -6.76e-02 0.012300 1.73e-01 8.04e-01
SIGNALING BY NOTCH3 48 7.58e-01 8.66e-01 0.06820 -6.20e-02 -0.028500 4.58e-01 7.33e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 7.28e-01 8.49e-01 0.06780 -6.75e-02 -0.007170 4.49e-01 9.36e-01
DISEASES OF MITOTIC CELL CYCLE 37 7.04e-01 8.31e-01 0.06750 -1.38e-02 0.066100 8.85e-01 4.87e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.95e-01 7.04e-01 0.06750 -3.53e-02 -0.057500 4.78e-01 2.47e-01
SURFACTANT METABOLISM 16 9.15e-01 9.54e-01 0.06740 6.06e-02 0.029400 6.75e-01 8.39e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 9.49e-01 9.70e-01 0.06670 5.85e-02 0.032200 7.49e-01 8.60e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 7.00e-01 8.29e-01 0.06610 5.82e-02 -0.031400 5.57e-01 7.51e-01
MEIOTIC SYNAPSIS 40 6.71e-01 8.11e-01 0.06600 2.44e-02 -0.061300 7.90e-01 5.02e-01
SIGNALING BY NOTCH2 32 7.22e-01 8.44e-01 0.06570 -5.93e-02 0.028300 5.62e-01 7.82e-01
OTHER INTERLEUKIN SIGNALING 20 8.45e-01 9.21e-01 0.06570 6.53e-02 -0.007370 6.13e-01 9.54e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 192 1.42e-01 3.34e-01 0.06570 -5.86e-02 0.029600 1.62e-01 4.80e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 8.83e-01 9.40e-01 0.06540 1.95e-02 0.062500 8.77e-01 6.20e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 7.65e-01 8.70e-01 0.06540 3.81e-02 0.053100 6.19e-01 4.88e-01
RND3 GTPASE CYCLE 37 8.40e-01 9.17e-01 0.06530 -3.76e-02 -0.053300 6.92e-01 5.75e-01
G ALPHA Q SIGNALLING EVENTS 165 2.66e-01 5.04e-01 0.06450 -6.58e-03 0.064100 8.84e-01 1.56e-01
AMINO ACIDS REGULATE MTORC1 51 6.24e-01 7.84e-01 0.06440 6.12e-02 -0.020100 4.50e-01 8.04e-01
PENTOSE PHOSPHATE PATHWAY 13 9.45e-01 9.69e-01 0.06380 4.10e-02 0.048900 7.98e-01 7.60e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 8.99e-01 9.47e-01 0.06370 -2.24e-02 -0.059600 8.62e-01 6.45e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 2.53e-01 4.90e-01 0.06330 6.15e-02 0.014700 1.03e-01 6.97e-01
SMOOTH MUSCLE CONTRACTION 34 8.36e-01 9.16e-01 0.06310 2.15e-02 0.059300 8.28e-01 5.49e-01
SIGNALLING TO RAS 19 8.27e-01 9.12e-01 0.06290 4.14e-02 -0.047500 7.55e-01 7.20e-01
TRANSLESION SYNTHESIS BY POLK 17 8.52e-01 9.22e-01 0.06260 -5.55e-02 0.028900 6.92e-01 8.36e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 7.58e-01 8.66e-01 0.06260 5.00e-02 0.037600 4.86e-01 6.00e-01
REGULATION OF TP53 ACTIVITY 149 3.42e-01 5.67e-01 0.06230 3.15e-03 -0.062200 9.47e-01 1.90e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.23e-01 9.58e-01 0.06140 4.33e-02 0.043600 7.38e-01 7.36e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 8.51e-01 9.22e-01 0.06140 -3.82e-02 0.048100 7.85e-01 7.31e-01
SIGNALING BY INSULIN RECEPTOR 63 7.76e-01 8.76e-01 0.06140 -4.60e-02 -0.040800 5.28e-01 5.76e-01
NERVOUS SYSTEM DEVELOPMENT 550 7.94e-02 2.34e-01 0.06050 2.20e-02 0.056300 3.79e-01 2.44e-02
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 6.37e-01 7.94e-01 0.06040 -2.10e-02 -0.056700 7.25e-01 3.43e-01
SIGNALING BY MET 75 7.13e-01 8.38e-01 0.06000 2.42e-02 0.054900 7.17e-01 4.12e-01
RHOC GTPASE CYCLE 73 6.59e-01 8.07e-01 0.05990 -5.94e-02 -0.008090 3.81e-01 9.05e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 8.88e-01 9.42e-01 0.05980 2.30e-02 0.055200 8.39e-01 6.26e-01
VESICLE MEDIATED TRANSPORT 611 6.46e-03 3.95e-02 0.05940 2.93e-02 -0.051600 2.17e-01 3.00e-02
G ALPHA 12 13 SIGNALLING EVENTS 74 5.24e-01 7.26e-01 0.05910 -3.72e-02 0.046000 5.81e-01 4.95e-01
PROCESSING AND ACTIVATION OF SUMO 10 9.51e-01 9.71e-01 0.05900 1.52e-02 0.057000 9.34e-01 7.55e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 7.76e-01 8.76e-01 0.05890 2.81e-04 0.058900 9.98e-01 5.14e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 8.39e-01 9.17e-01 0.05850 -3.06e-02 -0.049900 7.23e-01 5.63e-01
REGULATION OF SIGNALING BY CBL 22 8.37e-01 9.16e-01 0.05830 -5.18e-02 0.026600 6.74e-01 8.29e-01
MEMBRANE TRAFFICKING 581 1.23e-02 6.64e-02 0.05800 2.31e-02 -0.053200 3.44e-01 2.91e-02
SIGNALING BY BRAF AND RAF FUSIONS 60 7.79e-01 8.76e-01 0.05760 -5.28e-02 -0.023100 4.80e-01 7.57e-01
HEME BIOSYNTHESIS 13 9.13e-01 9.53e-01 0.05740 -1.28e-02 0.056000 9.36e-01 7.27e-01
NICOTINAMIDE SALVAGING 16 9.45e-01 9.69e-01 0.05730 -4.43e-02 -0.036300 7.59e-01 8.01e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 7.78e-01 8.76e-01 0.05670 -4.25e-02 0.037600 6.82e-01 7.17e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.22e-01 9.58e-01 0.05620 -2.26e-02 0.051400 8.97e-01 7.68e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 629 1.29e-01 3.16e-01 0.05570 -3.38e-02 -0.044200 1.49e-01 5.94e-02
NEPHRIN FAMILY INTERACTIONS 23 8.85e-01 9.41e-01 0.05520 -5.52e-02 -0.002230 6.47e-01 9.85e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 8.31e-01 9.14e-01 0.05470 5.22e-02 -0.016300 6.33e-01 8.82e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 8.81e-01 9.40e-01 0.05450 5.45e-02 -0.002400 6.51e-01 9.84e-01
SIGNALING BY FGFR3 35 8.22e-01 9.08e-01 0.05420 -4.21e-03 0.054100 9.66e-01 5.80e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 347 1.08e-01 2.78e-01 0.05410 -1.73e-02 0.051300 5.81e-01 1.02e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 9.25e-01 9.59e-01 0.05300 3.35e-02 -0.041100 8.48e-01 8.13e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 67 7.19e-01 8.43e-01 0.05300 1.49e-03 0.053000 9.83e-01 4.53e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 7.02e-01 8.31e-01 0.05270 1.89e-02 -0.049200 8.07e-01 5.25e-01
RAB REGULATION OF TRAFFICKING 119 4.69e-01 6.82e-01 0.05260 2.02e-02 -0.048500 7.03e-01 3.61e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 8.49e-01 9.22e-01 0.05210 5.00e-02 0.014600 5.70e-01 8.69e-01
ONCOGENIC MAPK SIGNALING 77 6.03e-01 7.68e-01 0.05170 -4.34e-02 0.028200 5.11e-01 6.69e-01
UB SPECIFIC PROCESSING PROTEASES 167 5.60e-01 7.50e-01 0.05150 4.83e-02 0.017900 2.82e-01 6.90e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 8.29e-01 9.12e-01 0.05110 -4.71e-02 0.019800 6.50e-01 8.48e-01
CELLULAR SENESCENCE 143 4.01e-01 6.23e-01 0.05050 3.62e-02 -0.035100 4.55e-01 4.69e-01
EPH EPHRIN SIGNALING 92 6.70e-01 8.11e-01 0.05030 -5.02e-02 -0.002460 4.05e-01 9.67e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 7.67e-01 8.70e-01 0.05010 -2.29e-02 -0.044600 7.10e-01 4.70e-01
TP53 REGULATES METABOLIC GENES 85 5.86e-01 7.59e-01 0.05010 -3.23e-02 0.038200 6.06e-01 5.43e-01
DNA REPAIR 291 1.85e-01 3.94e-01 0.05000 2.11e-02 -0.045400 5.37e-01 1.84e-01
DEATH RECEPTOR SIGNALLING 133 6.91e-01 8.25e-01 0.04870 -2.33e-02 -0.042700 6.43e-01 3.95e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 117 6.47e-01 7.99e-01 0.04860 7.03e-03 0.048100 8.96e-01 3.69e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 366 1.91e-01 4.02e-01 0.04860 -5.46e-03 0.048300 8.58e-01 1.14e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 8.70e-01 9.34e-01 0.04840 3.99e-02 -0.027300 7.35e-01 8.17e-01
RHOA GTPASE CYCLE 142 6.85e-01 8.22e-01 0.04830 -2.47e-02 -0.041500 6.11e-01 3.94e-01
ESTROGEN DEPENDENT GENE EXPRESSION 104 5.75e-01 7.55e-01 0.04820 -4.46e-02 0.018100 4.32e-01 7.49e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 466 3.00e-01 5.36e-01 0.04810 -4.11e-02 -0.025100 1.30e-01 3.55e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 9.27e-01 9.60e-01 0.04790 4.19e-02 0.023300 7.01e-01 8.31e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 8.01e-01 8.92e-01 0.04790 -2.66e-02 -0.039800 6.69e-01 5.21e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.05e-01 9.49e-01 0.04760 9.41e-03 0.046700 9.30e-01 6.63e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 7.59e-01 8.66e-01 0.04740 4.71e-02 -0.005030 5.18e-01 9.45e-01
COPII MEDIATED VESICLE TRANSPORT 66 6.91e-01 8.25e-01 0.04730 3.04e-02 -0.036200 6.69e-01 6.11e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 8.82e-01 9.40e-01 0.04690 4.56e-02 -0.010700 6.81e-01 9.24e-01
SIGNALING BY GPCR 494 3.05e-01 5.37e-01 0.04650 -3.95e-02 -0.024600 1.34e-01 3.51e-01
DEVELOPMENTAL BIOLOGY 821 6.41e-02 2.05e-01 0.04650 5.47e-03 0.046200 7.91e-01 2.54e-02
SIGNALING BY FGFR4 33 8.90e-01 9.43e-01 0.04630 4.70e-03 0.046100 9.63e-01 6.47e-01
M PHASE 341 1.78e-01 3.88e-01 0.04560 3.73e-02 -0.026200 2.38e-01 4.08e-01
REGULATION OF INSULIN SECRETION 71 7.68e-01 8.70e-01 0.04540 -4.53e-02 0.000653 5.09e-01 9.92e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 8.09e-01 9.00e-01 0.04530 -4.33e-04 -0.045300 9.95e-01 5.51e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 9.56e-01 9.75e-01 0.04520 -3.60e-02 -0.027400 7.81e-01 8.32e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 7.57e-01 8.66e-01 0.04510 4.50e-02 -0.000586 4.97e-01 9.93e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 7.49e-01 8.61e-01 0.04460 -4.39e-02 0.007840 5.23e-01 9.09e-01
ADAPTIVE IMMUNE SYSTEM 601 7.18e-02 2.20e-01 0.04420 -1.72e-02 0.040800 4.73e-01 8.92e-02
RHO GTPASE EFFECTORS 251 4.97e-01 7.04e-01 0.04340 -4.25e-02 -0.008920 2.48e-01 8.08e-01
POTENTIAL THERAPEUTICS FOR SARS 77 7.56e-01 8.66e-01 0.04330 4.31e-02 -0.004430 5.14e-01 9.46e-01
TRANSCRIPTION OF THE HIV GENOME 67 8.60e-01 9.27e-01 0.04310 3.88e-02 0.018800 5.83e-01 7.90e-01
PHOSPHOLIPID METABOLISM 185 6.74e-01 8.14e-01 0.04280 -2.07e-02 -0.037400 6.27e-01 3.81e-01
REGULATED NECROSIS 46 8.95e-01 9.45e-01 0.04200 1.30e-02 0.039900 8.79e-01 6.39e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 8.51e-01 9.22e-01 0.04170 -3.28e-02 0.025800 7.30e-01 7.86e-01
HEMOSTASIS 471 1.71e-01 3.78e-01 0.04170 -3.97e-02 0.012700 1.42e-01 6.38e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 26 8.99e-01 9.47e-01 0.04100 -2.02e-02 0.035700 8.58e-01 7.53e-01
MET ACTIVATES PTK2 SIGNALING 29 8.92e-01 9.43e-01 0.04080 3.65e-02 -0.018100 7.34e-01 8.66e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 9.11e-01 9.52e-01 0.04040 3.87e-02 -0.011400 7.32e-01 9.20e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 8.19e-01 9.07e-01 0.04020 -3.37e-03 -0.040000 9.60e-01 5.52e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 9.22e-01 9.58e-01 0.03990 -2.96e-02 -0.026700 7.23e-01 7.49e-01
FLT3 SIGNALING IN DISEASE 28 9.37e-01 9.66e-01 0.03970 9.35e-03 0.038600 9.32e-01 7.24e-01
O LINKED GLYCOSYLATION OF MUCINS 39 8.80e-01 9.40e-01 0.03950 3.86e-02 -0.008710 6.77e-01 9.25e-01
PRE NOTCH EXPRESSION AND PROCESSING 64 9.01e-01 9.48e-01 0.03900 -2.53e-02 -0.029700 7.26e-01 6.81e-01
MET PROMOTES CELL MOTILITY 39 9.06e-01 9.49e-01 0.03870 -3.86e-02 -0.002440 6.77e-01 9.79e-01
N GLYCAN ANTENNAE ELONGATION 15 9.51e-01 9.71e-01 0.03850 -1.26e-02 0.036400 9.33e-01 8.07e-01
NUCLEOTIDE EXCISION REPAIR 109 7.79e-01 8.76e-01 0.03830 3.78e-02 0.005890 4.95e-01 9.15e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 51 8.51e-01 9.22e-01 0.03750 -1.26e-02 0.035300 8.76e-01 6.63e-01
INTEGRIN SIGNALING 24 9.24e-01 9.58e-01 0.03750 -1.54e-02 0.034100 8.96e-01 7.72e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 9.31e-01 9.61e-01 0.03670 3.57e-02 -0.008780 7.58e-01 9.39e-01
G ALPHA S SIGNALLING EVENTS 105 7.46e-01 8.59e-01 0.03570 -1.04e-02 0.034200 8.54e-01 5.46e-01
DNA DOUBLE STRAND BREAK RESPONSE 53 8.46e-01 9.22e-01 0.03550 2.20e-02 -0.027800 7.82e-01 7.26e-01
TRANSCRIPTIONAL REGULATION BY TP53 340 5.78e-01 7.56e-01 0.03530 -1.23e-02 -0.033100 6.97e-01 2.95e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 9.45e-01 9.69e-01 0.03490 3.49e-02 0.000518 7.58e-01 9.96e-01
CELL CYCLE CHECKPOINTS 242 7.45e-01 8.59e-01 0.03400 2.28e-02 0.025200 5.43e-01 5.00e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 9.48e-01 9.70e-01 0.03350 3.24e-02 -0.008680 7.93e-01 9.44e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 9.60e-01 9.78e-01 0.03210 9.76e-03 0.030600 9.28e-01 7.76e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 9.77e-01 9.90e-01 0.03120 2.65e-02 0.016500 8.34e-01 8.96e-01
TRANSPORT OF SMALL MOLECULES 580 2.95e-01 5.29e-01 0.03060 -1.21e-02 0.028100 6.20e-01 2.50e-01
SEMAPHORIN INTERACTIONS 64 8.63e-01 9.29e-01 0.03030 2.34e-02 -0.019200 7.46e-01 7.91e-01
SENSORY PERCEPTION 147 7.62e-01 8.67e-01 0.03020 5.17e-03 -0.029800 9.14e-01 5.33e-01
CELL CYCLE MITOTIC 474 3.52e-01 5.75e-01 0.03010 1.87e-02 -0.023500 4.86e-01 3.82e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1216 1.07e-01 2.78e-01 0.02970 9.64e-03 -0.028100 5.75e-01 1.02e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.64e-01 9.80e-01 0.02950 -2.53e-02 -0.015200 7.90e-01 8.73e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 9.63e-01 9.80e-01 0.02940 -2.83e-02 0.008150 8.27e-01 9.50e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 8.83e-01 9.40e-01 0.02940 -2.49e-02 0.015600 7.41e-01 8.36e-01
PLATELET AGGREGATION PLUG FORMATION 32 9.41e-01 9.68e-01 0.02930 8.48e-03 -0.028100 9.34e-01 7.84e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 9.47e-01 9.70e-01 0.02870 -1.27e-02 0.025800 9.07e-01 8.13e-01
INTEGRIN CELL SURFACE INTERACTIONS 71 9.08e-01 9.49e-01 0.02860 -2.85e-02 -0.002450 6.78e-01 9.72e-01
SIGNALING BY FGFR IN DISEASE 55 9.41e-01 9.68e-01 0.02810 -2.69e-02 -0.007930 7.30e-01 9.19e-01
INTEGRATION OF ENERGY METABOLISM 98 8.28e-01 9.12e-01 0.02770 2.06e-02 -0.018500 7.25e-01 7.52e-01
OXIDATIVE STRESS INDUCED SENESCENCE 79 8.63e-01 9.29e-01 0.02740 2.18e-02 -0.016600 7.38e-01 7.99e-01
DUAL INCISION IN GG NER 40 9.33e-01 9.62e-01 0.02660 1.44e-02 -0.022300 8.75e-01 8.07e-01
CONDENSATION OF PROPHASE CHROMOSOMES 28 9.70e-01 9.85e-01 0.02640 -2.61e-02 -0.003930 8.11e-01 9.71e-01
MAPK FAMILY SIGNALING CASCADES 287 7.28e-01 8.49e-01 0.02550 1.24e-03 0.025500 9.71e-01 4.58e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 281 7.78e-01 8.76e-01 0.02540 -2.44e-02 -0.006890 4.82e-01 8.43e-01
PERK REGULATES GENE EXPRESSION 28 9.69e-01 9.85e-01 0.02490 0.00e+00 -0.024900 1.00e+00 8.20e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.86e-01 9.94e-01 0.02380 -6.60e-03 0.022900 9.70e-01 8.95e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 9.88e-01 9.94e-01 0.02350 2.33e-02 0.002620 8.84e-01 9.87e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 9.39e-01 9.67e-01 0.02310 1.99e-02 0.011700 7.27e-01 8.38e-01
METABOLISM OF PORPHYRINS 19 9.81e-01 9.93e-01 0.02280 -2.26e-02 0.002750 8.64e-01 9.83e-01
MYD88 INDEPENDENT TLR4 CASCADE 92 8.96e-01 9.45e-01 0.02210 -1.88e-02 0.011700 7.56e-01 8.46e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 9.87e-01 9.94e-01 0.02070 2.05e-02 -0.002530 8.91e-01 9.86e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 9.87e-01 9.94e-01 0.01950 -3.74e-03 -0.019100 9.76e-01 8.77e-01
CARGO CONCENTRATION IN THE ER 31 9.73e-01 9.87e-01 0.01920 8.84e-03 -0.017000 9.32e-01 8.70e-01
TRANSLESION SYNTHESIS BY POLH 19 9.85e-01 9.94e-01 0.01820 1.66e-02 -0.007530 9.00e-01 9.55e-01
CELL CYCLE 589 6.46e-01 7.99e-01 0.01820 6.95e-03 -0.016800 7.74e-01 4.87e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 9.90e-01 9.94e-01 0.01700 6.21e-04 0.016900 9.96e-01 8.93e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.92e-01 9.95e-01 0.01620 -3.83e-03 -0.015700 9.76e-01 9.01e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 9.73e-01 9.87e-01 0.01610 -1.58e-02 0.003020 8.45e-01 9.70e-01
PLATELET SENSITIZATION BY LDL 15 9.91e-01 9.94e-01 0.01570 1.35e-02 -0.007990 9.28e-01 9.57e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 9.31e-01 9.61e-01 0.01550 -1.13e-02 -0.010600 7.43e-01 7.59e-01
NOD1 2 SIGNALING PATHWAY 34 9.88e-01 9.94e-01 0.01240 -4.97e-03 0.011400 9.60e-01 9.09e-01
SIGNALING BY NOTCH1 75 9.89e-01 9.94e-01 0.01180 -7.26e-03 -0.009260 9.13e-01 8.90e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 9.82e-01 9.93e-01 0.01070 9.20e-04 -0.010600 9.88e-01 8.67e-01
MTOR SIGNALLING 40 9.93e-01 9.95e-01 0.00888 8.44e-03 -0.002760 9.26e-01 9.76e-01
HDACS DEACETYLATE HISTONES 47 9.95e-01 9.96e-01 0.00694 1.98e-03 -0.006650 9.81e-01 9.37e-01
DEUBIQUITINATION 241 9.96e-01 9.96e-01 0.00295 2.84e-03 -0.000783 9.40e-01 9.83e-01


Detailed Gene set reports


EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
metric value
setSize 87
pMANOVA 3.51e-33
p.adjustMANOVA 2.06e-30
s.dist 0.814
s.LPS 0.3
s.OVA 0.757
p.LPS 1.29e-06
p.OVA 2.29e-34




Top 20 genes
Gene LPS OVA
Eef1d 7466 7063
Rpl8 6585 7421
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Rpl36 5913 7632
Rpl13 6166 7174
Rps20 5501 7927
Rpsa 5435 7738
Eef1b2 6050 6896
Rplp1 5261 7624
Fau 5367 7428
Rplp2 4989 7648
Rpl19 5546 6846
Rps15 5393 6984
Rps8 4981 7370

Click HERE to show all gene set members

All member genes
LPS OVA
Eef1a1 4368 6242
Eef1a2 4090 -4809
Eef1b2 6050 6896
Eef1d 7466 7063
Eef1g 984 5647
Eef2 5786 4596
Fau 5367 7428
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Uba52 4571 7320



SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
metric value
setSize 106
pMANOVA 2.39e-32
p.adjustMANOVA 9.37e-30
s.dist 0.723
s.LPS 0.254
s.OVA 0.677
p.LPS 6.28e-06
p.OVA 1.71e-33




Top 20 genes
Gene LPS OVA
Rpl8 6585 7421
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Rpl36 5913 7632
Rpl13 6166 7174
Rps20 5501 7927
Sec61g 5282 8011
Rpsa 5435 7738
Ssr4 6356 6475
Rplp1 5261 7624
Fau 5367 7428
Sec61b 5177 7542
Rplp2 4989 7648
Rpl19 5546 6846
Rps15 5393 6984

Click HERE to show all gene set members

All member genes
LPS OVA
Ddost 6409 2865
Fau 5367 7428
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rpn1 4995 3392
Rpn2 6176 5525
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Sec11a -216 2992
Sec11c -1019 5408
Sec61a1 4888 505
Sec61a2 -4996 -5425
Sec61b 5177 7542
Sec61g 5282 8011
Spcs1 2558 7605
Spcs2 -344 4903
Spcs3 -8165 -1008
Srp14 2200 2657
Srp19 390 5880
Srp54a -6104 2528
Srp68 6255 157
Srp72 4186 -1832
Srp9 -3614 4160
Srpr 6466 63
Srprb 5692 -3731
Ssr1 -4516 -1070
Ssr2 4435 4806
Ssr3 -3652 7760
Ssr4 6356 6475
Tram1 -5654 6722
Uba52 4571 7320



RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
metric value
setSize 95
pMANOVA 3.39e-27
p.adjustMANOVA 7.97e-25
s.dist 0.69
s.LPS 0.222
s.OVA 0.653
p.LPS 0.000183
p.OVA 3.37e-28




Top 20 genes
Gene LPS OVA
Rpl8 6585 7421
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Rpl36 5913 7632
Rpl13 6166 7174
Rps20 5501 7927
Rpsa 5435 7738
Rplp1 5261 7624
Fau 5367 7428
Rplp2 4989 7648
Rpl19 5546 6846
Rps15 5393 6984
Rps8 4981 7370
Rps15a 5456 6415
Uba52 4571 7320

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -4362 -6330
Atf2 -7620 -6209
Atf3 6753 1498
Atf4 5387 -533
Cebpb 6325 -2814
Cebpg -6988 -977
Ddit3 4288 4049
Eif2ak4 -4313 -7309
Eif2s1 -5540 -2133
Eif2s2 -5712 3809
Eif2s3x -3699 3841
Fau 5367 7428
Gcn1 5002 1947
Impact -486 2348
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Trib3 -3571 2809
Uba52 4571 7320



REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
metric value
setSize 10
pMANOVA 0.00292
p.adjustMANOVA 0.0211
s.dist 0.676
s.LPS -0.26
s.OVA -0.624
p.LPS 0.155
p.OVA 0.000634




Top 20 genes
Gene LPS OVA
Robo2 -8121 -5141
Robo3 -6652 -5943
Ntn1 -5677 -4853
Robo1 -7725 -3153
Dcc -8429 -1794

Click HERE to show all gene set members

All member genes
LPS OVA
Dcc -8429 -1794
Nell2 4069 -7486
Ntn1 -5677 -4853
Robo1 -7725 -3153
Robo2 -8121 -5141
Robo3 -6652 -5943
Slit1 3444 -6942
Slit2 209 -4658
Slit3 1770 -7270
Src 4051 -4489



EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION
metric value
setSize 114
pMANOVA 1.96e-30
p.adjustMANOVA 5.75e-28
s.dist 0.663
s.LPS 0.204
s.OVA 0.631
p.LPS 0.000165
p.OVA 2.33e-31




Top 20 genes
Gene LPS OVA
Eif4a1 7428 7714
Eif3b 7633 7179
Rpl8 6585 7421
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Rpl36 5913 7632
Rpl13 6166 7174
Rps20 5501 7927
Rpsa 5435 7738
Eif3l 6344 6595
Eif2b5 6354 6433
Rplp1 5261 7624
Eif3f 4927 8099
Fau 5367 7428
Eif3d 7020 5542

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7792 -5140
Eif2b1 -1744 -5600
Eif2b2 7707 1150
Eif2b3 -3474 452
Eif2b4 4724 5762
Eif2b5 6354 6433
Eif2s1 -5540 -2133
Eif2s2 -5712 3809
Eif2s3x -3699 3841
Eif3a 191 -5789
Eif3b 7633 7179
Eif3c 3166 407
Eif3d 7020 5542
Eif3e -7456 5707
Eif3f 4927 8099
Eif3g 5107 2046
Eif3h 5016 4167
Eif3i 6161 5375
Eif3j1 -5827 481
Eif3j2 -5547 7554
Eif3k 4248 5009
Eif3l 6344 6595
Eif3m -3386 6058
Eif4a1 7428 7714
Eif4a2 -7771 -2028
Eif4b -1944 -2666
Eif4e -563 3691
Eif4ebp1 -3318 4468
Eif4g1 5028 -2224
Eif4h 4879 -21
Eif5 -7860 -3703
Eif5b -5788 991
Fau 5367 7428
Pabpc1 -6865 5518
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Uba52 4571 7320



REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS
metric value
setSize 11
pMANOVA 0.00475
p.adjustMANOVA 0.0308
s.dist 0.65
s.LPS -0.557
s.OVA -0.336
p.LPS 0.00138
p.OVA 0.0539




Top 20 genes
Gene LPS OVA
Atp2a3 -7117 -7764
Atp2b4 -7728 -4940
Atp2b1 -8469 -2697
Atp2a2 -4252 -2766
Atp2b2 -6913 -1256
Atp2b3 -1348 -4162
Slc8a1 -8169 -122

Click HERE to show all gene set members

All member genes
LPS OVA
Atp2a2 -4252 -2766
Atp2a3 -7117 -7764
Atp2b1 -8469 -2697
Atp2b2 -6913 -1256
Atp2b3 -1348 -4162
Atp2b4 -7728 -4940
Calm1 -7889 1508
Slc8a1 -8169 -122
Slc8a2 4124 -6847
Slc8a3 1448 -6020
Sri -6752 5037



YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
metric value
setSize 11
pMANOVA 0.00152
p.adjustMANOVA 0.0127
s.dist 0.633
s.LPS 0.144
s.OVA 0.616
p.LPS 0.408
p.OVA 0.000401




Top 20 genes
Gene LPS OVA
Tead2 8234 8285
Ccn2 7629 8086
Yap1 6444 8500
Tead1 2641 7590
Tead3 3962 2128
Runx2 517 3045

Click HERE to show all gene set members

All member genes
LPS OVA
Ccn2 7629 8086
Hipk1 -4115 1113
Hipk2 -2628 6372
Kat2b -4284 3853
Nppa -1228 3379
Runx2 517 3045
Tead1 2641 7590
Tead2 8234 8285
Tead3 3962 2128
Wwtr1 -4909 6336
Yap1 6444 8500



POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
metric value
setSize 17
pMANOVA 5.34e-06
p.adjustMANOVA 0.000131
s.dist 0.629
s.LPS 0.629
s.OVA -0.00378
p.LPS 7.13e-06
p.OVA 0.978




Top 20 genes
Gene LPS OVA
Tubb4a 7131 -5162
Tubb3 7161 -4850
Tuba8 4697 -6669
Tuba4a 5110 -5122
Tbcc 2421 -4427
Tubb2b 6404 -908
Tbcd 4999 -584
Arl2 6273 -296

Click HERE to show all gene set members

All member genes
LPS OVA
Arl2 6273 -296
Tbca -1002 5744
Tbcb 6927 3401
Tbcc 2421 -4427
Tbcd 4999 -584
Tbce -3110 -7029
Tuba1a 7803 6914
Tuba1b 7786 6589
Tuba1c 2923 6641
Tuba4a 5110 -5122
Tuba8 4697 -6669
Tubb2a 7932 1275
Tubb2b 6404 -908
Tubb3 7161 -4850
Tubb4a 7131 -5162
Tubb4b 7939 1028
Tubb6 7355 4840



SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM
metric value
setSize 109
pMANOVA 1.38e-24
p.adjustMANOVA 2.31e-22
s.dist 0.629
s.LPS 0.241
s.OVA 0.581
p.LPS 1.43e-05
p.OVA 1.04e-25




Top 20 genes
Gene LPS OVA
Rpl8 6585 7421
Aimp2 6191 7844
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Ahcy 5635 8422
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Rpl36 5913 7632
Rpl13 6166 7174
Rps20 5501 7927
Rpsa 5435 7738
Qars 5806 7195
Rplp1 5261 7624
Fau 5367 7428
Rplp2 4989 7648
Rpl19 5546 6846
Rps15 5393 6984

Click HERE to show all gene set members

All member genes
LPS OVA
Ahcy 5635 8422
Aimp1 4740 6218
Aimp2 6191 7844
Cbs -350 1293
Cth -3514 7158
Dars -6590 -5524
Eef1e1 5005 5632
Eefsec 5826 735
Eprs -7825 -4234
Fau 5367 7428
Gnmt 274 -3918
Gsr -5440 1979
Hnmt -8497 -2903
Iars -1514 -7683
Kars 2951 1021
Lars -6725 -4561
Mars1 7772 -3072
Nnmt 4721 7152
Papss1 2900 2370
Papss2 -520 2943
Pstk 5554 6003
Qars 5806 7195
Rars -12 -3126
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Sars 1047 -8010
Scly 7581 -2830
Secisbp2 727 -7345
Sephs2 6329 4877
Sepsecs -6991 -6723
Txnrd1 1930 -5164
Uba52 4571 7320



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 6.43e-05
p.adjustMANOVA 0.00101
s.dist 0.614
s.LPS 0.581
s.OVA 0.199
p.LPS 1.17e-05
p.OVA 0.133




Top 20 genes
Gene LPS OVA
Tuba1a 7803 6914
Cct3 7150 7328
Tuba1b 7786 6589
Tubb6 7355 4840
Cct5 7868 4489
Cct7 7182 4059
Cct4 3765 7332
Tuba1c 2923 6641
Tubb2a 7932 1275
Tubb4b 7939 1028
Cct2 615 4093

Click HERE to show all gene set members

All member genes
LPS OVA
Cct2 615 4093
Cct3 7150 7328
Cct4 3765 7332
Cct5 7868 4489
Cct6a -2043 1880
Cct7 7182 4059
Cct8 -2170 -1207
Tcp1 -3169 1673
Tuba1a 7803 6914
Tuba1b 7786 6589
Tuba1c 2923 6641
Tuba4a 5110 -5122
Tuba8 4697 -6669
Tubb2a 7932 1275
Tubb2b 6404 -908
Tubb3 7161 -4850
Tubb4a 7131 -5162
Tubb4b 7939 1028
Tubb6 7355 4840



ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
metric value
setSize 59
pMANOVA 3.25e-14
p.adjustMANOVA 2.55e-12
s.dist 0.609
s.LPS 0.162
s.OVA 0.587
p.LPS 0.0315
p.OVA 6.12e-15




Top 20 genes
Gene LPS OVA
Eif4a1 7428 7714
Eif3b 7633 7179
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rps21 5711 8071
Rps28 5823 7817
Rps20 5501 7927
Rpsa 5435 7738
Eif3l 6344 6595
Eif3f 4927 8099
Fau 5367 7428
Eif3d 7020 5542
Rps15 5393 6984
Rps8 4981 7370
Rps15a 5456 6415
Eif3i 6161 5375
Rps10 4337 7197
Rps9 4133 7517
Rps19 3724 7798

Click HERE to show all gene set members

All member genes
LPS OVA
Eif1ax -7792 -5140
Eif2s1 -5540 -2133
Eif2s2 -5712 3809
Eif2s3x -3699 3841
Eif3a 191 -5789
Eif3b 7633 7179
Eif3c 3166 407
Eif3d 7020 5542
Eif3e -7456 5707
Eif3f 4927 8099
Eif3g 5107 2046
Eif3h 5016 4167
Eif3i 6161 5375
Eif3j1 -5827 481
Eif3j2 -5547 7554
Eif3k 4248 5009
Eif3l 6344 6595
Eif3m -3386 6058
Eif4a1 7428 7714
Eif4a2 -7771 -2028
Eif4b -1944 -2666
Eif4e -563 3691
Eif4ebp1 -3318 4468
Eif4g1 5028 -2224
Eif4h 4879 -21
Fau 5367 7428
Pabpc1 -6865 5518
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738



CGMP EFFECTS

CGMP EFFECTS
metric value
setSize 15
pMANOVA 0.000804
p.adjustMANOVA 0.00801
s.dist 0.604
s.LPS -0.563
s.OVA -0.22
p.LPS 0.00016
p.OVA 0.141




Top 20 genes
Gene LPS OVA
Kcnmb2 -8570 -8257
Pde1b -8150 -6566
Prkg1 -5058 -7915
Pde11a -3873 -7536
Kcnma1 -7252 -3510
Pde10a -8087 -2422
Pde1a -7924 -2300
Itpr1 -7359 -2191
Pde2a -7400 -2152

Click HERE to show all gene set members

All member genes
LPS OVA
Irag1 -1223 4221
Itpr1 -7359 -2191
Kcnma1 -7252 -3510
Kcnmb1 4514 -5124
Kcnmb2 -8570 -8257
Kcnmb4 -3805 7807
Pde10a -8087 -2422
Pde11a -3873 -7536
Pde1a -7924 -2300
Pde1b -8150 -6566
Pde2a -7400 -2152
Pde5a -6707 5759
Pde9a 2566 3713
Prkg1 -5058 -7915
Prkg2 -4769 261



TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
metric value
setSize 13
pMANOVA 0.000784
p.adjustMANOVA 0.00787
s.dist 0.604
s.LPS 0.592
s.OVA 0.122
p.LPS 0.000221
p.OVA 0.448




Top 20 genes
Gene LPS OVA
Tuba1a 7803 6914
Tuba1b 7786 6589
Tubb6 7355 4840
Tuba1c 2923 6641
Tubb2a 7932 1275
Tubb4b 7939 1028

Click HERE to show all gene set members

All member genes
LPS OVA
Gja1 -4274 5555
Gjb2 -4191 4745
Tuba1a 7803 6914
Tuba1b 7786 6589
Tuba1c 2923 6641
Tuba4a 5110 -5122
Tuba8 4697 -6669
Tubb2a 7932 1275
Tubb2b 6404 -908
Tubb3 7161 -4850
Tubb4a 7131 -5162
Tubb4b 7939 1028
Tubb6 7355 4840



P75NTR REGULATES AXONOGENESIS

P75NTR REGULATES AXONOGENESIS
metric value
setSize 10
pMANOVA 0.0197
p.adjustMANOVA 0.0916
s.dist 0.592
s.LPS -0.492
s.OVA -0.33
p.LPS 0.0071
p.OVA 0.071




Top 20 genes
Gene LPS OVA
Mcf2 -7929 -7908
Rtn4r -6148 -8057
Omg -7253 -6689
Rtn4 -7609 -4563
Mag -4606 -4675
Lingo1 -2603 -8221
Ngfr -6633 -237

Click HERE to show all gene set members

All member genes
LPS OVA
Arhgdia 8053 5850
Lingo1 -2603 -8221
Mag -4606 -4675
Mcf2 -7929 -7908
Ngf -4901 1225
Ngfr -6633 -237
Omg -7253 -6689
Rhoa -3082 6471
Rtn4 -7609 -4563
Rtn4r -6148 -8057



ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS

ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
metric value
setSize 10
pMANOVA 0.0105
p.adjustMANOVA 0.0583
s.dist 0.587
s.LPS -0.202
s.OVA -0.551
p.LPS 0.269
p.OVA 0.00255




Top 20 genes
Gene LPS OVA
Mapk8 -8249 -7435
Atf2 -7620 -6209
Mapk10 -4332 -6171
Mapk9 -3953 -5739
Mapk1 -8326 -2420
Fos -1386 -7854

Click HERE to show all gene set members

All member genes
LPS OVA
Atf2 -7620 -6209
Fos -1386 -7854
Jun 3924 -7567
Mapk1 -8326 -2420
Mapk10 -4332 -6171
Mapk11 5281 -4750
Mapk14 1858 -1633
Mapk3 4626 4229
Mapk8 -8249 -7435
Mapk9 -3953 -5739



NEUROTOXICITY OF CLOSTRIDIUM TOXINS

NEUROTOXICITY OF CLOSTRIDIUM TOXINS
metric value
setSize 10
pMANOVA 0.0248
p.adjustMANOVA 0.107
s.dist 0.586
s.LPS -0.376
s.OVA -0.45
p.LPS 0.0397
p.OVA 0.0138




Top 20 genes
Gene LPS OVA
Snap25 -8522 -7926
Syt1 -8572 -6695
Sv2b -8102 -7007
Syt2 -7579 -2641
Vamp1 -1061 -5101
Sv2c -3778 -950

Click HERE to show all gene set members

All member genes
LPS OVA
Snap25 -8522 -7926
Stx1a 7210 -4497
Stx1b 399 -5781
Sv2a 627 -3035
Sv2b -8102 -7007
Sv2c -3778 -950
Syt1 -8572 -6695
Syt2 -7579 -2641
Vamp1 -1061 -5101
Vamp2 -3508 6676



HDR THROUGH MMEJ ALT NHEJ

HDR THROUGH MMEJ ALT NHEJ
metric value
setSize 10
pMANOVA 0.0287
p.adjustMANOVA 0.119
s.dist 0.572
s.LPS -0.355
s.OVA -0.449
p.LPS 0.052
p.OVA 0.014




Top 20 genes
Gene LPS OVA
Rad50 -8453 -7852
Rbbp8 -6146 -8262
Nbn -5710 -7263
Parp1 -5167 -7466
Parp2 -3982 -4716
Lig3 -2781 -2421

Click HERE to show all gene set members

All member genes
LPS OVA
Fen1 408 -7125
Lig3 -2781 -2421
Mre11a -2935 129
Nbn -5710 -7263
Parp1 -5167 -7466
Parp2 -3982 -4716
Polq -3553 363
Rad50 -8453 -7852
Rbbp8 -6146 -8262
Xrcc1 7201 7742



ENDOSOMAL VACUOLAR PATHWAY

ENDOSOMAL VACUOLAR PATHWAY
metric value
setSize 11
pMANOVA 0.000193
p.adjustMANOVA 0.00242
s.dist 0.567
s.LPS -0.276
s.OVA 0.495
p.LPS 0.113
p.OVA 0.00445




Top 20 genes
Gene LPS OVA
B2m -7815 6590
H2-T23 -7621 5173
H2-Q7 -5369 6481
H2-D1 -5192 4707
Lnpep -5803 2485
Ctss -3152 2932
H2-Q2 -533 5285

Click HERE to show all gene set members

All member genes
LPS OVA
B2m -7815 6590
Ctsl 3419 4912
Ctss -3152 2932
H2-Bl 4707 4764
H2-D1 -5192 4707
H2-M3 -2355 -246
H2-Q10 2862 4329
H2-Q2 -533 5285
H2-Q7 -5369 6481
H2-T23 -7621 5173
Lnpep -5803 2485



CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS

CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS
metric value
setSize 12
pMANOVA 0.00865
p.adjustMANOVA 0.0496
s.dist 0.564
s.LPS -0.234
s.OVA -0.513
p.LPS 0.16
p.OVA 0.00209




Top 20 genes
Gene LPS OVA
Gabbr2 -4114 -7996
Grm5 -8314 -2781
Casr -3657 -5374
Grm2 -2373 -8184
Grm1 -7415 -2612
Grm3 -8339 -2097
Grm4 -1688 -7336

Click HERE to show all gene set members

All member genes
LPS OVA
Casr -3657 -5374
Gabbr1 2233 -3142
Gabbr2 -4114 -7996
Grm1 -7415 -2612
Grm2 -2373 -8184
Grm3 -8339 -2097
Grm4 -1688 -7336
Grm5 -8314 -2781
Grm7 823 -6616
Grm8 3847 -4636
Tas1r1 6258 -1390
Tas1r3 -2353 1364



NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD
metric value
setSize 109
pMANOVA 1.75e-20
p.adjustMANOVA 2.28e-18
s.dist 0.564
s.LPS 0.197
s.OVA 0.528
p.LPS 0.000379
p.OVA 1.54e-21




Top 20 genes
Gene LPS OVA
Rpl8 6585 7421
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Rpl36 5913 7632
Rpl13 6166 7174
Rps20 5501 7927
Rpsa 5435 7738
Rplp1 5261 7624
Fau 5367 7428
Rplp2 4989 7648
Rpl19 5546 6846
Rps15 5393 6984
Rps8 4981 7370
Rps15a 5456 6415
Uba52 4571 7320

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All member genes
LPS OVA
Casc3 572 -3995
Dcp1a -4542 -5060
Eif4a3 3535 3509
Eif4g1 5028 -2224
Etf1 -5321 -5317
Fau 5367 7428
Gspt1 -965 -2332
Gspt2 2508 -4741
Magoh 1334 7732
Magohb -2575 -6703
Ncbp1 4078 6644
Ncbp2 -6147 -5244
Pabpc1 -6865 5518
Pnrc2 -5197 5172
Ppp2ca 2972 -2703
Ppp2r1a 1735 -4346
Ppp2r2a -7273 -5268
Rbm8a -996 6210
Rnps1 -2824 -2011
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Smg1 -3249 275
Smg5 6955 -3878
Smg6 -1046 -6602
Smg7 -7204 -285
Smg8 -1908 -5226
Smg9 4685 -6746
Uba52 4571 7320
Upf1 6015 -2725
Upf2 3277 -51
Upf3a 389 -1435
Upf3b 82 -600



FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
metric value
setSize 18
pMANOVA 0.000262
p.adjustMANOVA 0.00308
s.dist 0.557
s.LPS 0.125
s.OVA 0.543
p.LPS 0.359
p.OVA 6.69e-05




Top 20 genes
Gene LPS OVA
Atp5k 5706 7127
mt-Atp8 4021 7997
Atp5d 5782 5287
Atp5e 2730 7348
Atp5g1 5286 3348
Atp5g2 1392 8351
Atp5l 1540 6453
Atp5j2 2050 3871
Atp5b 2732 2751
Atp5j 1201 3831
Atp5g3 552 5969
Atp5h 187 6231
Atp5a1 264 3478
Atp5o 1963 98

Click HERE to show all gene set members

All member genes
LPS OVA
Atp5a1 264 3478
Atp5b 2732 2751
Atp5c1 -2591 3510
Atp5d 5782 5287
Atp5e 2730 7348
Atp5g1 5286 3348
Atp5g2 1392 8351
Atp5g3 552 5969
Atp5h 187 6231
Atp5j 1201 3831
Atp5j2 2050 3871
Atp5k 5706 7127
Atp5l 1540 6453
Atp5o 1963 98
Atp5pb -2001 823
Dmac2l -6805 1961
mt-Atp6 -6867 6349
mt-Atp8 4021 7997



COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 1.1e-10
p.adjustMANOVA 6.43e-09
s.dist 0.556
s.LPS 0.191
s.OVA 0.523
p.LPS 0.0133
p.OVA 1.32e-11




Top 20 genes
Gene LPS OVA
Ndufa2 6084 7874
Ndufaf6 7697 5974
Timmdc1 6640 6659
Ndufb2 5640 7621
Ndufb10 5856 6669
Ndufv1 5257 6550
Ndufaf5 4552 7306
Ndufaf3 7585 4361
Ndufa1 4520 7211
Ndufb1 4993 6469
Ndufa6 5426 5703
Ecsit 4978 6203
Ndufs5 5544 5353
Ndufa13 5502 5337
Ndufb8 4882 5973
Ndufs7 7071 4105
Ndufb11 4311 6609
Ndufb7 5168 4924
Ndufa11 4907 5111
Ndufa7 4009 5896

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 7184 -238
Ecsit 4978 6203
mt-Nd1 -6350 6107
mt-Nd2 -5135 6600
mt-Nd3 -6170 7840
mt-Nd4 -6825 6610
mt-Nd5 -6420 6941
mt-Nd6 -4598 7426
Ndufa1 4520 7211
Ndufa10 -1597 -3056
Ndufa11 4907 5111
Ndufa12 897 3633
Ndufa13 5502 5337
Ndufa2 6084 7874
Ndufa3 3716 5991
Ndufa5 -426 5102
Ndufa6 5426 5703
Ndufa7 4009 5896
Ndufa8 2455 3273
Ndufa9 -4159 883
Ndufab1 4218 5488
Ndufaf1 -3802 6802
Ndufaf2 -5651 1335
Ndufaf3 7585 4361
Ndufaf4 -5978 -1989
Ndufaf5 4552 7306
Ndufaf6 7697 5974
Ndufaf7 2502 6593
Ndufb1 4993 6469
Ndufb10 5856 6669
Ndufb11 4311 6609
Ndufb2 5640 7621
Ndufb3 -730 2043
Ndufb4 -1295 5820
Ndufb5 -603 4681
Ndufb6 731 4752
Ndufb7 5168 4924
Ndufb8 4882 5973
Ndufb9 -303 6511
Ndufc1 244 5855
Ndufc2 1751 5872
Ndufs1 -4600 -3892
Ndufs2 3048 3749
Ndufs3 2649 7121
Ndufs4 -4321 3532
Ndufs5 5544 5353
Ndufs6 2859 6188
Ndufs7 7071 4105
Ndufs8 6562 3002
Ndufv1 5257 6550
Ndufv2 -2331 2392
Ndufv3 1676 3058
Nubpl -2946 3899
Timmdc1 6640 6659
Tmem126b 4953 -1177
Tmem186 2751 -7025



NITRIC OXIDE STIMULATES GUANYLATE CYCLASE

NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
metric value
setSize 20
pMANOVA 0.000336
p.adjustMANOVA 0.00383
s.dist 0.553
s.LPS -0.516
s.OVA -0.198
p.LPS 6.38e-05
p.OVA 0.125




Top 20 genes
Gene LPS OVA
Kcnmb2 -8570 -8257
Gucy1a1 -8528 -7759
Pde1b -8150 -6566
Prkg1 -5058 -7915
Gucy1b1 -6874 -4611
Pde11a -3873 -7536
Kcnma1 -7252 -3510
Pde10a -8087 -2422
Pde1a -7924 -2300
Itpr1 -7359 -2191
Pde2a -7400 -2152

Click HERE to show all gene set members

All member genes
LPS OVA
Gucy1a1 -8528 -7759
Gucy1a2 -5545 3479
Gucy1b1 -6874 -4611
Irag1 -1223 4221
Itpr1 -7359 -2191
Kcnma1 -7252 -3510
Kcnmb1 4514 -5124
Kcnmb2 -8570 -8257
Kcnmb4 -3805 7807
Nos1 2764 -3144
Nos3 1711 6974
Pde10a -8087 -2422
Pde11a -3873 -7536
Pde1a -7924 -2300
Pde1b -8150 -6566
Pde2a -7400 -2152
Pde5a -6707 5759
Pde9a 2566 3713
Prkg1 -5058 -7915
Prkg2 -4769 261



VOLTAGE GATED POTASSIUM CHANNELS

VOLTAGE GATED POTASSIUM CHANNELS
metric value
setSize 39
pMANOVA 5.77e-06
p.adjustMANOVA 0.000138
s.dist 0.538
s.LPS -0.399
s.OVA -0.361
p.LPS 1.59e-05
p.OVA 9.68e-05




Top 20 genes
Gene LPS OVA
Kcnq1 -7261 -8331
Kcns1 -8367 -6883
Kcnh7 -8498 -6445
Kcna2 -8511 -5462
Kcnq5 -7964 -5765
Kcng1 -7704 -5304
Kcnd1 -4838 -7823
Kcnab3 -7658 -4922
Kcns2 -4915 -7662
Kcnf1 -4973 -7259
Kcna4 -5253 -6587
Kcnd3 -7414 -4034
Kcna6 -3942 -6499
Kcnb1 -3789 -5490
Kcnd2 -6958 -2440
Kcng4 -2527 -6642
Kcnq3 -7808 -1434
Kcnc1 -2095 -4856
Kcnv1 -7952 -1260
Kcnq2 -2003 -4582

Click HERE to show all gene set members

All member genes
LPS OVA
Kcna1 -6266 2029
Kcna2 -8511 -5462
Kcna3 -577 -1076
Kcna4 -5253 -6587
Kcna5 800 -544
Kcna6 -3942 -6499
Kcnab1 -8308 546
Kcnab2 -427 -4060
Kcnab3 -7658 -4922
Kcnb1 -3789 -5490
Kcnb2 -5906 1533
Kcnc1 -2095 -4856
Kcnc2 -7506 1713
Kcnc3 1698 1417
Kcnc4 4328 -5967
Kcnd1 -4838 -7823
Kcnd2 -6958 -2440
Kcnd3 -7414 -4034
Kcnf1 -4973 -7259
Kcng1 -7704 -5304
Kcng2 3939 -2356
Kcng4 -2527 -6642
Kcnh1 -2670 -1942
Kcnh2 3342 -3710
Kcnh3 -6943 228
Kcnh4 -1503 -1048
Kcnh5 -5287 -317
Kcnh6 5674 -35
Kcnh7 -8498 -6445
Kcnh8 105 1844
Kcnq1 -7261 -8331
Kcnq2 -2003 -4582
Kcnq3 -7808 -1434
Kcnq4 2691 -776
Kcnq5 -7964 -5765
Kcns1 -8367 -6883
Kcns2 -4915 -7662
Kcns3 7397 7618
Kcnv1 -7952 -1260



APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION
metric value
setSize 10
pMANOVA 0.0334
p.adjustMANOVA 0.133
s.dist 0.529
s.LPS -0.474
s.OVA -0.235
p.LPS 0.00946
p.OVA 0.198




Top 20 genes
Gene LPS OVA
H1f0 -8541 -8338
H1f2 -8562 -2743
Kpnb1 -1903 -3385
H1f4 -2594 -2482
Dffb -1316 -4366
Casp3 -2336 -1371

Click HERE to show all gene set members

All member genes
LPS OVA
Casp3 -2336 -1371
Dffa 3164 -6155
Dffb -1316 -4366
H1f0 -8541 -8338
H1f2 -8562 -2743
H1f4 -2594 -2482
Hmgb1 -7075 5779
Hmgb2 -5764 3183
Kpna1 -6282 1094
Kpnb1 -1903 -3385



CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
metric value
setSize 46
pMANOVA 8.38e-07
p.adjustMANOVA 3.04e-05
s.dist 0.529
s.LPS 0.324
s.OVA 0.418
p.LPS 0.000145
p.OVA 9.2e-07




Top 20 genes
Gene LPS OVA
Psmd3 7906 6874
Psmd13 7257 6934
Sem1 6780 7133
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6134
Psmb2 6181 7346
Psme2 5471 8073
Psmb4 6894 6170
Psmc3 6685 6181
Mrc2 6977 5912
Psmc5 6075 6612
Psmd10 5799 6776
Psmb6 6328 5605
Psme1 7334 4527
Psmd8 5319 6063
Psmb7 4527 6187
Psmb10 4823 5736
Psmb1 4454 5798
Psmd4 6593 3487

Click HERE to show all gene set members

All member genes
LPS OVA
Fcgr1 -4206 1929
Mrc1 -3314 -3867
Mrc2 6977 5912
Psma1 -841 5990
Psma2 4136 4577
Psma3 -1199 7147
Psma4 -129 1872
Psma5 5707 3541
Psma6 2305 4518
Psma7 3997 4636
Psmb1 4454 5798
Psmb10 4823 5736
Psmb2 6181 7346
Psmb3 3563 5507
Psmb4 6894 6170
Psmb5 7413 6134
Psmb6 6328 5605
Psmb7 4527 6187
Psmb8 -6833 3639
Psmb9 -7423 903
Psmc1 -2672 1369
Psmc2 4814 429
Psmc3 6685 6181
Psmc4 8055 5833
Psmc5 6075 6612
Psmc6 -5038 -5235
Psmd1 1229 -2030
Psmd10 5799 6776
Psmd11 -2333 825
Psmd12 -4517 -7819
Psmd13 7257 6934
Psmd14 136 6699
Psmd2 4198 -917
Psmd3 7906 6874
Psmd4 6593 3487
Psmd5 1732 -1274
Psmd6 2247 5119
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3345 6663
Psme1 7334 4527
Psme2 5471 8073
Psme3 -86 3238
Psme4 -5571 -2401
Psmf1 -1094 -378
Sem1 6780 7133



SEROTONIN NEUROTRANSMITTER RELEASE CYCLE

SEROTONIN NEUROTRANSMITTER RELEASE CYCLE
metric value
setSize 18
pMANOVA 0.000962
p.adjustMANOVA 0.00906
s.dist 0.528
s.LPS -0.155
s.OVA -0.504
p.LPS 0.255
p.OVA 0.000211




Top 20 genes
Gene LPS OVA
Snap25 -8522 -7926
Syt1 -8572 -6695
Ppfia2 -6851 -5989
Cplx1 -8021 -3531
Rims1 -7557 -3739
Syn3 -5843 -3668
Ppfia1 -4169 -4795
Syn1 -1021 -6787
Stxbp1 -254 -6825
Tspoap1 -272 -4670

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All member genes
LPS OVA
Cplx1 -8021 -3531
Ppfia1 -4169 -4795
Ppfia2 -6851 -5989
Ppfia3 7570 -155
Ppfia4 7531 -1751
Rab3a 4340 -4178
Rims1 -7557 -3739
Slc18a2 808 -7290
Snap25 -8522 -7926
Stx1a 7210 -4497
Stxbp1 -254 -6825
Syn1 -1021 -6787
Syn2 1078 -5118
Syn3 -5843 -3668
Syt1 -8572 -6695
Tspoap1 -272 -4670
Unc13b 507 -3920
Vamp2 -3508 6676



KERATAN SULFATE DEGRADATION

KERATAN SULFATE DEGRADATION
metric value
setSize 12
pMANOVA 0.0281
p.adjustMANOVA 0.117
s.dist 0.524
s.LPS 0.326
s.OVA 0.41
p.LPS 0.0503
p.OVA 0.0139




Top 20 genes
Gene LPS OVA
Prelp 6526 7868
Lum 5854 7972
Hexa 7151 6502
Fmod 5939 7485
Galns 5018 5256
Omd 2832 5483
Glb1l 3588 4272

Click HERE to show all gene set members

All member genes
LPS OVA
Acan -3716 -8349
Fmod 5939 7485
Galns 5018 5256
Glb1 2423 -4177
Glb1l 3588 4272
Gns 2331 -2315
Hexa 7151 6502
Hexb -5601 6092
Lum 5854 7972
Ogn -438 6953
Omd 2832 5483
Prelp 6526 7868



SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
metric value
setSize 23
pMANOVA 7.56e-05
p.adjustMANOVA 0.00114
s.dist 0.523
s.LPS 0.512
s.OVA 0.104
p.LPS 2.12e-05
p.OVA 0.388




Top 20 genes
Gene LPS OVA
Lemd2 8238 7577
Tuba1a 7803 6914
Tuba1b 7786 6589
Chmp4b 7509 5296
Tubb6 7355 4840
Chmp2a 3767 5951
Tuba1c 2923 6641
Tubb2a 7932 1275
Tubb4b 7939 1028

Click HERE to show all gene set members

All member genes
LPS OVA
Cc2d1b 4192 -1796
Chmp2a 3767 5951
Chmp2b -8285 3360
Chmp3 -110 -3605
Chmp4b 7509 5296
Chmp4c -2081 7790
Chmp6 6102 -1182
Chmp7 6767 -3465
Ist1 -1811 3576
Lemd2 8238 7577
Spast -3690 -2568
Tuba1a 7803 6914
Tuba1b 7786 6589
Tuba1c 2923 6641
Tuba4a 5110 -5122
Tuba8 4697 -6669
Tubb2a 7932 1275
Tubb2b 6404 -908
Tubb3 7161 -4850
Tubb4a 7131 -5162
Tubb4b 7939 1028
Tubb6 7355 4840
Vps4a 4460 -2639



REGULATION OF EXPRESSION OF SLITS AND ROBOS

REGULATION OF EXPRESSION OF SLITS AND ROBOS
metric value
setSize 160
pMANOVA 4.3e-24
p.adjustMANOVA 6.32e-22
s.dist 0.521
s.LPS 0.216
s.OVA 0.474
p.LPS 2.45e-06
p.OVA 3.81e-25




Top 20 genes
Gene LPS OVA
Psmd3 7906 6874
Psmd13 7257 6934
Rpl8 6585 7421
Sem1 6780 7133
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Psmd7 8072 5831
Psmc4 8055 5833
Rpl38 5942 7799
Rps21 5711 8071
Rps28 5823 7817
Psmb5 7413 6134
Psmb2 6181 7346
Rpl36 5913 7632
Rpl13 6166 7174
Psme2 5471 8073
Rps20 5501 7927
Psmb4 6894 6170

Click HERE to show all gene set members

All member genes
LPS OVA
Casc3 572 -3995
Col4a5 4062 2458
Cul2 -3997 -3751
Dag1 -836 925
Eif4a3 3535 3509
Eif4g1 5028 -2224
Elob 6245 6315
Eloc -8236 1088
Etf1 -5321 -5317
Fau 5367 7428
Gspt1 -965 -2332
Gspt2 2508 -4741
Isl1 3919 5940
Ldb1 -858 -2520
Lhx2 -6780 -4657
Lhx9 -5705 -6239
Magoh 1334 7732
Magohb -2575 -6703
Msi1 -1011 -3977
Ncbp1 4078 6644
Ncbp2 -6147 -5244
Pabpc1 -6865 5518
Psma1 -841 5990
Psma2 4136 4577
Psma3 -1199 7147
Psma4 -129 1872
Psma5 5707 3541
Psma6 2305 4518
Psma7 3997 4636
Psmb1 4454 5798
Psmb10 4823 5736
Psmb2 6181 7346
Psmb3 3563 5507
Psmb4 6894 6170
Psmb5 7413 6134
Psmb6 6328 5605
Psmb7 4527 6187
Psmb8 -6833 3639
Psmb9 -7423 903
Psmc1 -2672 1369
Psmc2 4814 429
Psmc3 6685 6181
Psmc4 8055 5833
Psmc5 6075 6612
Psmc6 -5038 -5235
Psmd1 1229 -2030
Psmd10 5799 6776
Psmd11 -2333 825
Psmd12 -4517 -7819
Psmd13 7257 6934
Psmd14 136 6699
Psmd2 4198 -917
Psmd3 7906 6874
Psmd4 6593 3487
Psmd5 1732 -1274
Psmd6 2247 5119
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3345 6663
Psme1 7334 4527
Psme2 5471 8073
Psme3 -86 3238
Psme4 -5571 -2401
Psmf1 -1094 -378
Rbm8a -996 6210
Rbx1 -2574 1802
Rnps1 -2824 -2011
Robo1 -7725 -3153
Robo2 -8121 -5141
Robo3 -6652 -5943
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Sem1 6780 7133
Slit1 3444 -6942
Slit2 209 -4658
Uba52 4571 7320
Ubb 7203 86
Ubc 2605 -7072
Upf2 3277 -51
Upf3a 389 -1435
Upf3b 82 -600
Usp33 -3258 -3996
Zswim8 2272 -3664



ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS

ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
metric value
setSize 10
pMANOVA 0.0186
p.adjustMANOVA 0.0873
s.dist 0.505
s.LPS -0.0816
s.OVA -0.498
p.LPS 0.655
p.OVA 0.00637




Top 20 genes
Gene LPS OVA
Chrna5 -6175 -5272
Chrna1 -4326 -7105
Chrnb3 -1883 -8315
Chrna4 -1669 -7639
Chrna6 -1290 -8351
Chrna2 -7410 -1447
Chrna7 -567 -5476

Click HERE to show all gene set members

All member genes
LPS OVA
Chrna1 -4326 -7105
Chrna2 -7410 -1447
Chrna3 4591 520
Chrna4 -1669 -7639
Chrna5 -6175 -5272
Chrna6 -1290 -8351
Chrna7 -567 -5476
Chrnb2 4831 -2502
Chrnb3 -1883 -8315
Chrnb4 5928 4505



HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS

HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
metric value
setSize 10
pMANOVA 0.0186
p.adjustMANOVA 0.0873
s.dist 0.505
s.LPS -0.0816
s.OVA -0.498
p.LPS 0.655
p.OVA 0.00637




Top 20 genes
Gene LPS OVA
Chrna5 -6175 -5272
Chrna1 -4326 -7105
Chrnb3 -1883 -8315
Chrna4 -1669 -7639
Chrna6 -1290 -8351
Chrna2 -7410 -1447
Chrna7 -567 -5476

Click HERE to show all gene set members

All member genes
LPS OVA
Chrna1 -4326 -7105
Chrna2 -7410 -1447
Chrna3 4591 520
Chrna4 -1669 -7639
Chrna5 -6175 -5272
Chrna6 -1290 -8351
Chrna7 -567 -5476
Chrnb2 4831 -2502
Chrnb3 -1883 -8315
Chrnb4 5928 4505



RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA

RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA
metric value
setSize 24
pMANOVA 0.00111
p.adjustMANOVA 0.01
s.dist 0.504
s.LPS -0.283
s.OVA -0.417
p.LPS 0.0164
p.OVA 0.000406




Top 20 genes
Gene LPS OVA
Blm -8306 -8353
Rad50 -8453 -7852
Rbbp8 -6146 -8262
Palb2 -6484 -7359
Wrn -6599 -6550
Nbn -5710 -7263
Rad51ap1 -4845 -7207
Rad51 -3685 -7817
Rad51d -2692 -7556
Xrcc3 -1703 -7934
Rmi2 -1763 -5695
Bard1 -3229 -2070
Top3a -942 -6599
Dna2 -157 -6202

Click HERE to show all gene set members

All member genes
LPS OVA
Atm -5069 284
Bard1 -3229 -2070
Blm -8306 -8353
Brca1 2697 6886
Brca2 -2937 4067
Brip1 4528 7441
Dna2 -157 -6202
Kat5 6330 -5301
Mre11a -2935 129
Nbn -5710 -7263
Palb2 -6484 -7359
Rad50 -8453 -7852
Rad51 -3685 -7817
Rad51ap1 -4845 -7207
Rad51c 580 -4044
Rad51d -2692 -7556
Rbbp8 -6146 -8262
Rmi1 -2282 2806
Rmi2 -1763 -5695
Rtel1 235 -4737
Top3a -942 -6599
Wrn -6599 -6550
Xrcc2 -467 7193
Xrcc3 -1703 -7934



DSCAM INTERACTIONS

DSCAM INTERACTIONS
metric value
setSize 10
pMANOVA 0.059
p.adjustMANOVA 0.195
s.dist 0.501
s.LPS -0.274
s.OVA -0.42
p.LPS 0.134
p.OVA 0.0216




Top 20 genes
Gene LPS OVA
Mapk8 -8249 -7435
Pak1 -4951 -6384
Ntn1 -5677 -4853
Dscaml1 -4812 -3523
Dcc -8429 -1794

Click HERE to show all gene set members

All member genes
LPS OVA
Dcc -8429 -1794
Dscam 1579 -5758
Dscaml1 -4812 -3523
Mapk11 5281 -4750
Mapk12 2515 -2589
Mapk14 1858 -1633
Mapk8 -8249 -7435
Ntn1 -5677 -4853
Pak1 -4951 -6384
Rac1 -3364 4304



PHASE 0 RAPID DEPOLARISATION

PHASE 0 RAPID DEPOLARISATION
metric value
setSize 30
pMANOVA 0.000355
p.adjustMANOVA 0.00401
s.dist 0.495
s.LPS -0.309
s.OVA -0.386
p.LPS 0.00345
p.OVA 0.000249




Top 20 genes
Gene LPS OVA
Scn3b -6810 -7457
Fgf14 -7558 -6620
Fgf12 -8154 -4504
Cacng6 -5730 -6360
Fgf13 -4738 -7652
Cacnb2 -4894 -6684
Camk2d -7178 -4023
Scn4b -7778 -3676
Scn8a -7951 -3434
Cacng7 -3844 -6947
Scn1a -7809 -2335
Scn2a -5630 -1970
Cacna2d2 -2539 -2554
Scn2b -1681 -3555
Camk2a -7583 -712
Scn3a -5687 -860
Fgf11 -7686 -231

Click HERE to show all gene set members

All member genes
LPS OVA
Cacna1c 1729 274
Cacna2d2 -2539 -2554
Cacnb1 1006 -6850
Cacnb2 -4894 -6684
Cacng4 4453 -2513
Cacng6 -5730 -6360
Cacng7 -3844 -6947
Cacng8 3579 -2218
Calm1 -7889 1508
Camk2a -7583 -712
Camk2b 1424 -7170
Camk2d -7178 -4023
Camk2g 4816 -7791
Fgf11 -7686 -231
Fgf12 -8154 -4504
Fgf13 -4738 -7652
Fgf14 -7558 -6620
Rangrf 302 -499
Scn11a 4630 929
Scn1a -7809 -2335
Scn1b 1637 -6250
Scn2a -5630 -1970
Scn2b -1681 -3555
Scn3a -5687 -860
Scn3b -6810 -7457
Scn4b -7778 -3676
Scn5a 2696 -4626
Scn7a 1451 4267
Scn8a -7951 -3434
Scn9a 1915 5796



RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
metric value
setSize 125
pMANOVA 2.64e-18
p.adjustMANOVA 3.11e-16
s.dist 0.492
s.LPS 0.16
s.OVA 0.465
p.LPS 0.00201
p.OVA 2.8e-19




Top 20 genes
Gene LPS OVA
Ucp2 8047 7601
Ndufa2 6084 7874
Ndufaf6 7697 5974
Timmdc1 6640 6659
Ndufb2 5640 7621
Surf1 5903 6926
Atp5k 5706 7127
Ndufb10 5856 6669
Cyc1 6855 5565
Ndufv1 5257 6550
Ndufaf5 4552 7306
Ndufaf3 7585 4361
Ndufa1 4520 7211
Ndufb1 4993 6469
mt-Atp8 4021 7997
Ndufa6 5426 5703
Ecsit 4978 6203
Atp5d 5782 5287
Uqcr10 5312 5658
Ndufs5 5544 5353

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 7184 -238
Atp5a1 264 3478
Atp5b 2732 2751
Atp5c1 -2591 3510
Atp5d 5782 5287
Atp5e 2730 7348
Atp5g1 5286 3348
Atp5g2 1392 8351
Atp5g3 552 5969
Atp5h 187 6231
Atp5j 1201 3831
Atp5j2 2050 3871
Atp5k 5706 7127
Atp5l 1540 6453
Atp5o 1963 98
Atp5pb -2001 823
Coq10a 4176 1680
Coq10b -4268 5985
Cox11 464 1334
Cox14 3478 2134
Cox16 1100 5465
Cox18 5536 2907
Cox19 772 -1021
Cox20 -1938 5150
Cox4i1 1156 6148
Cox5a 1924 5179
Cox5b 2827 5976
Cox6a1 3670 7303
Cox6b1 2762 5478
Cox6c -308 4973
Cox7a2l -1130 6223
Cox7b -83 2699
Cox7c -2831 5166
Cox8a 5031 5621
Cyc1 6855 5565
Cycs -7079 1125
Dmac2l -6805 1961
Ecsit 4978 6203
Etfa -2040 3556
Etfb 3380 5668
Etfdh 485 -4475
Lrpprc -827 -6264
mt-Atp6 -6867 6349
mt-Atp8 4021 7997
mt-Co1 -6015 6683
mt-Co2 -5074 6098
mt-Co3 -5783 5816
mt-Cytb -5600 6163
mt-Nd1 -6350 6107
mt-Nd2 -5135 6600
mt-Nd3 -6170 7840
mt-Nd4 -6825 6610
mt-Nd5 -6420 6941
mt-Nd6 -4598 7426
Ndufa1 4520 7211
Ndufa10 -1597 -3056
Ndufa11 4907 5111
Ndufa12 897 3633
Ndufa13 5502 5337
Ndufa2 6084 7874
Ndufa3 3716 5991
Ndufa4 -2873 4270
Ndufa5 -426 5102
Ndufa6 5426 5703
Ndufa7 4009 5896
Ndufa8 2455 3273
Ndufa9 -4159 883
Ndufab1 4218 5488
Ndufaf1 -3802 6802
Ndufaf2 -5651 1335
Ndufaf3 7585 4361
Ndufaf4 -5978 -1989
Ndufaf5 4552 7306
Ndufaf6 7697 5974
Ndufaf7 2502 6593
Ndufb1 4993 6469
Ndufb10 5856 6669
Ndufb11 4311 6609
Ndufb2 5640 7621
Ndufb3 -730 2043
Ndufb4 -1295 5820
Ndufb5 -603 4681
Ndufb6 731 4752
Ndufb7 5168 4924
Ndufb8 4882 5973
Ndufb9 -303 6511
Ndufc1 244 5855
Ndufc2 1751 5872
Ndufs1 -4600 -3892
Ndufs2 3048 3749
Ndufs3 2649 7121
Ndufs4 -4321 3532
Ndufs5 5544 5353
Ndufs6 2859 6188
Ndufs7 7071 4105
Ndufs8 6562 3002
Ndufv1 5257 6550
Ndufv2 -2331 2392
Ndufv3 1676 3058
Nubpl -2946 3899
Pm20d1 3297 7169
Sco1 -3592 -5698
Sco2 6761 -1165
Sdha 1654 -4472
Sdhb 5449 2810
Sdhc 2070 4642
Sdhd 3895 2541
Slc25a14 2493 7920
Slc25a27 -823 -7279
Surf1 5903 6926
Taco1 5039 3904
Timmdc1 6640 6659
Tmem126b 4953 -1177
Tmem186 2751 -7025
Trap1 5260 2654
Ucp2 8047 7601
Ucp3 -1555 -5618
Uqcr10 5312 5658
Uqcr11 3595 5725
Uqcrb -3797 2944
Uqcrc1 5172 3627
Uqcrc2 -4461 -1103
Uqcrfs1 980 1396
Uqcrh 195 5904
Uqcrq 4846 5949



TRANSLATION

TRANSLATION
metric value
setSize 286
pMANOVA 3.61e-34
p.adjustMANOVA 4.24e-31
s.dist 0.489
s.LPS 0.26
s.OVA 0.414
p.LPS 3.9e-14
p.OVA 1.7e-33




Top 20 genes
Gene LPS OVA
Apeh 8338 8362
Mrps35 7770 8113
Eral1 7602 8170
Mrps6 7465 7758
Eif4a1 7428 7714
Mrpl9 7432 7658
Mrpl14 7719 7230
Eif3b 7633 7179
Fars2 7632 6922
Eef1d 7466 7063
Mrpl23 6316 8302
Yars2 8248 6174
Rpl8 6585 7421
Aimp2 6191 7844
Rps29 5843 8224
Rps5 6498 7374
Rps6 6406 7422
Rpl39 5847 8123
Rpl38 5942 7799
Rps21 5711 8071

Click HERE to show all gene set members

All member genes
LPS OVA
Aars 4529 -5151
Aars2 7220 -2874
Aimp1 4740 6218
Aimp2 6191 7844
Apeh 8338 8362
Aurkaip1 5768 4923
Cars 6627 47
Cars2 5622 2527
Chchd1 4810 6700
Dap3 -1393 5795
Dars -6590 -5524
Dars2 -1361 3230
Ddost 6409 2865
Ears2 4904 2114
Eef1a1 4368 6242
Eef1a2 4090 -4809
Eef1b2 6050 6896
Eef1d 7466 7063
Eef1e1 5005 5632
Eef1g 984 5647
Eef2 5786 4596
Eif1ax -7792 -5140
Eif2b1 -1744 -5600
Eif2b2 7707 1150
Eif2b3 -3474 452
Eif2b4 4724 5762
Eif2b5 6354 6433
Eif2s1 -5540 -2133
Eif2s2 -5712 3809
Eif2s3x -3699 3841
Eif3a 191 -5789
Eif3b 7633 7179
Eif3c 3166 407
Eif3d 7020 5542
Eif3e -7456 5707
Eif3f 4927 8099
Eif3g 5107 2046
Eif3h 5016 4167
Eif3i 6161 5375
Eif3j1 -5827 481
Eif3j2 -5547 7554
Eif3k 4248 5009
Eif3l 6344 6595
Eif3m -3386 6058
Eif4a1 7428 7714
Eif4a2 -7771 -2028
Eif4b -1944 -2666
Eif4e -563 3691
Eif4ebp1 -3318 4468
Eif4g1 5028 -2224
Eif4h 4879 -21
Eif5 -7860 -3703
Eif5b -5788 991
Eprs -7825 -4234
Eral1 7602 8170
Etf1 -5321 -5317
Fars2 7632 6922
Farsa 6235 4794
Farsb 5094 -4913
Fau 5367 7428
Gadd45gip1 7336 2899
Gars 2530 -5178
Gfm1 -7112 -4211
Gfm2 1994 2075
Gspt1 -965 -2332
Gspt2 2508 -4741
Hars 4478 -490
Hars2 1336 1692
Iars -1514 -7683
Iars2 -592 937
Kars 2951 1021
Lars -6725 -4561
Lars2 -723 8526
Mars1 7772 -3072
Mars2 -6906 -198
Mrpl1 -7734 -7637
Mrpl10 169 -1199
Mrpl11 3821 6007
Mrpl12 6035 5939
Mrpl13 599 3040
Mrpl14 7719 7230
Mrpl15 782 4756
Mrpl16 646 7056
Mrpl17 3402 4614
Mrpl18 4865 2590
Mrpl19 2705 -1438
Mrpl2 3450 4348
Mrpl20 3055 4373
Mrpl21 3234 3815
Mrpl22 1328 -3361
Mrpl23 6316 8302
Mrpl24 4327 5620
Mrpl27 6158 3652
Mrpl28 5345 5699
Mrpl3 -3684 1949
Mrpl30 397 2532
Mrpl32 -5626 6960
Mrpl33 -1849 4929
Mrpl34 5986 5590
Mrpl35 2184 6733
Mrpl36 6877 6626
Mrpl37 5963 5911
Mrpl38 7754 259
Mrpl39 1339 -821
Mrpl4 7101 5738
Mrpl40 3526 701
Mrpl41 1539 5502
Mrpl42 1958 4669
Mrpl43 6958 5475
Mrpl44 -4394 -3166
Mrpl46 4613 5356
Mrpl47 -2214 7050
Mrpl48 -490 4617
Mrpl49 5051 537
Mrpl50 -5580 1031
Mrpl51 4312 8239
Mrpl52 5904 7357
Mrpl53 4890 6245
Mrpl54 3075 4678
Mrpl55 -410 -4896
Mrpl57 4097 4717
Mrpl58 4490 2007
Mrpl9 7432 7658
Mrps10 -3651 236
Mrps11 6165 2179
Mrps12 7312 628
Mrps14 -2871 4576
Mrps15 1131 6285
Mrps16 362 4866
Mrps17 1988 6322
Mrps18a 3715 791
Mrps18b -1817 1871
Mrps18c 1138 6582
Mrps2 -3568 -721
Mrps21 2685 4504
Mrps22 3948 2100
Mrps23 3497 6178
Mrps24 3115 3766
Mrps25 1635 1322
Mrps26 6384 3709
Mrps27 7380 4451
Mrps28 3957 449
Mrps30 4797 5682
Mrps31 -1648 -7096
Mrps33 1426 4427
Mrps34 7082 3931
Mrps35 7770 8113
Mrps36 -5480 115
Mrps5 -3954 -6845
Mrps6 7465 7758
Mrps7 5971 5105
Mrps9 6260 6764
Mrrf 7589 -1578
Mtfmt 2478 2738
Mtif2 -3906 54
Mtif3 -1446 -4339
Mtrf1l 3451 2371
N6amt1 -2834 -1335
Nars -1262 -1809
Nars2 -7368 3
Oxa1l 4575 3759
Pabpc1 -6865 5518
Pars2 5809 3982
Ppa1 5140 4243
Ppa2 2012 2466
Ptcd3 -6181 -8001
Qars 5806 7195
Rars -12 -3126
Rars2 -2041 -2033
Rpl10 4560 5827
Rpl10a 2645 6055
Rpl11 1982 5718
Rpl12 3660 4865
Rpl13 6166 7174
Rpl13a -807 7464
Rpl14 -729 6577
Rpl15 1348 5459
Rpl17 -2928 6302
Rpl18 4484 6800
Rpl18a 4061 7196
Rpl19 5546 6846
Rpl21 5181 6381
Rpl22 -2021 5543
Rpl22l1 -3934 7384
Rpl23 2289 6876
Rpl23a 3918 6521
Rpl24 -1380 5864
Rpl26 5486 5433
Rpl27 3570 6991
Rpl27a 2269 7298
Rpl28 714 4137
Rpl29 -1453 4792
Rpl3 176 7966
Rpl30 -6571 6236
Rpl31 3644 6712
Rpl32 1942 6811
Rpl34 1849 6997
Rpl35 3122 7651
Rpl35a -2844 6434
Rpl36 5913 7632
Rpl36a 3602 6311
Rpl36al 4567 7052
Rpl37 3274 6830
Rpl37a 4546 7336
Rpl38 5942 7799
Rpl39 5847 8123
Rpl4 3157 6151
Rpl5 -5335 5772
Rpl6 3088 4552
Rpl7 -484 6090
Rpl7a 4742 4292
Rpl8 6585 7421
Rpl9 494 7157
Rplp0 3002 6337
Rplp1 5261 7624
Rplp2 4989 7648
Rpn1 4995 3392
Rpn2 6176 5525
Rps10 4337 7197
Rps11 -893 5799
Rps12 3603 7178
Rps13 1005 7112
Rps14 2982 7130
Rps15 5393 6984
Rps15a 5456 6415
Rps16 -1524 7116
Rps17 2013 6662
Rps18 -5868 4459
Rps19 3724 7798
Rps2 -5575 2125
Rps20 5501 7927
Rps21 5711 8071
Rps23 -63 7075
Rps24 134 7168
Rps25 -958 6265
Rps26 556 5659
Rps27 3169 7849
Rps27a 2525 7575
Rps27l -3672 6933
Rps28 5823 7817
Rps29 5843 8224
Rps3 2674 7507
Rps3a1 3383 7393
Rps4x -1465 6462
Rps5 6498 7374
Rps6 6406 7422
Rps7 -3853 3248
Rps8 4981 7370
Rps9 4133 7517
Rpsa 5435 7738
Sars 1047 -8010
Sars2 1056 -3378
Sec11a -216 2992
Sec11c -1019 5408
Sec61a1 4888 505
Sec61a2 -4996 -5425
Sec61b 5177 7542
Sec61g 5282 8011
Spcs1 2558 7605
Spcs2 -344 4903
Spcs3 -8165 -1008
Srp14 2200 2657
Srp19 390 5880
Srp54a -6104 2528
Srp68 6255 157
Srp72 4186 -1832
Srp9 -3614 4160
Srpr 6466 63
Srprb 5692 -3731
Ssr1 -4516 -1070
Ssr2 4435 4806
Ssr3 -3652 7760
Ssr4 6356 6475
Tars 5999 -2407
Tars2 6777 3575
Tram1 -5654 6722
Trmt112 3877 2824
Tsfm 2670 2708
Tufm 7384 4428
Uba52 4571 7320
Vars 6718 3581
Vars2 4439 2067
Wars 5759 -3780
Wars2 -1656 -4111
Yars 6207 -4543
Yars2 8248 6174



AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA

AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
metric value
setSize 53
pMANOVA 1.34e-06
p.adjustMANOVA 4.27e-05
s.dist 0.489
s.LPS 0.325
s.OVA 0.365
p.LPS 4.23e-05
p.OVA 4.35e-06




Top 20 genes
Gene LPS OVA
Hspb1 7721 7881
Psmd3 7906 6874
Psmd13 7257 6934
Sem1 6780 7133
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6134
Psmb2 6181 7346
Psme2 5471 8073
Psmb4 6894 6170
Psmc3 6685 6181
Psmc5 6075 6612
Psmd10 5799 6776
Psmb6 6328 5605
Uba52 4571 7320
Psme1 7334 4527
Psmd8 5319 6063
Psmb7 4527 6187
Psmb10 4823 5736
Psmb1 4454 5798

Click HERE to show all gene set members

All member genes
LPS OVA
Eif4g1 5028 -2224
Hnrnpd -7246 -1249
Hspa1a -830 -8089
Hspa8 3706 -4244
Hspb1 7721 7881
Pabpc1 -6865 5518
Psma1 -841 5990
Psma2 4136 4577
Psma3 -1199 7147
Psma4 -129 1872
Psma5 5707 3541
Psma6 2305 4518
Psma7 3997 4636
Psmb1 4454 5798
Psmb10 4823 5736
Psmb2 6181 7346
Psmb3 3563 5507
Psmb4 6894 6170
Psmb5 7413 6134
Psmb6 6328 5605
Psmb7 4527 6187
Psmb8 -6833 3639
Psmb9 -7423 903
Psmc1 -2672 1369
Psmc2 4814 429
Psmc3 6685 6181
Psmc4 8055 5833
Psmc5 6075 6612
Psmc6 -5038 -5235
Psmd1 1229 -2030
Psmd10 5799 6776
Psmd11 -2333 825
Psmd12 -4517 -7819
Psmd13 7257 6934
Psmd14 136 6699
Psmd2 4198 -917
Psmd3 7906 6874
Psmd4 6593 3487
Psmd5 1732 -1274
Psmd6 2247 5119
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3345 6663
Psme1 7334 4527
Psme2 5471 8073
Psme3 -86 3238
Psme4 -5571 -2401
Psmf1 -1094 -378
Rps27a 2525 7575
Sem1 6780 7133
Uba52 4571 7320
Ubb 7203 86
Ubc 2605 -7072



RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 102
pMANOVA 6.77e-15
p.adjustMANOVA 6.63e-13
s.dist 0.489
s.LPS 0.16
s.OVA 0.462
p.LPS 0.00531
p.OVA 7.62e-16




Top 20 genes
Gene LPS OVA
Ndufa2 6084 7874
Ndufaf6 7697 5974
Timmdc1 6640 6659
Ndufb2 5640 7621
Surf1 5903 6926
Ndufb10 5856 6669
Cyc1 6855 5565
Ndufv1 5257 6550
Ndufaf5 4552 7306
Ndufaf3 7585 4361
Ndufa1 4520 7211
Ndufb1 4993 6469
Ndufa6 5426 5703
Ecsit 4978 6203
Uqcr10 5312 5658
Ndufs5 5544 5353
Ndufa13 5502 5337
Ndufb8 4882 5973
Ndufs7 7071 4105
Uqcrq 4846 5949

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 7184 -238
Coq10a 4176 1680
Coq10b -4268 5985
Cox11 464 1334
Cox14 3478 2134
Cox16 1100 5465
Cox18 5536 2907
Cox19 772 -1021
Cox20 -1938 5150
Cox4i1 1156 6148
Cox5a 1924 5179
Cox5b 2827 5976
Cox6a1 3670 7303
Cox6b1 2762 5478
Cox6c -308 4973
Cox7a2l -1130 6223
Cox7b -83 2699
Cox7c -2831 5166
Cox8a 5031 5621
Cyc1 6855 5565
Cycs -7079 1125
Ecsit 4978 6203
Etfa -2040 3556
Etfb 3380 5668
Etfdh 485 -4475
Lrpprc -827 -6264
mt-Co1 -6015 6683
mt-Co2 -5074 6098
mt-Co3 -5783 5816
mt-Cytb -5600 6163
mt-Nd1 -6350 6107
mt-Nd2 -5135 6600
mt-Nd3 -6170 7840
mt-Nd4 -6825 6610
mt-Nd5 -6420 6941
mt-Nd6 -4598 7426
Ndufa1 4520 7211
Ndufa10 -1597 -3056
Ndufa11 4907 5111
Ndufa12 897 3633
Ndufa13 5502 5337
Ndufa2 6084 7874
Ndufa3 3716 5991
Ndufa4 -2873 4270
Ndufa5 -426 5102
Ndufa6 5426 5703
Ndufa7 4009 5896
Ndufa8 2455 3273
Ndufa9 -4159 883
Ndufab1 4218 5488
Ndufaf1 -3802 6802
Ndufaf2 -5651 1335
Ndufaf3 7585 4361
Ndufaf4 -5978 -1989
Ndufaf5 4552 7306
Ndufaf6 7697 5974
Ndufaf7 2502 6593
Ndufb1 4993 6469
Ndufb10 5856 6669
Ndufb11 4311 6609
Ndufb2 5640 7621
Ndufb3 -730 2043
Ndufb4 -1295 5820
Ndufb5 -603 4681
Ndufb6 731 4752
Ndufb7 5168 4924
Ndufb8 4882 5973
Ndufb9 -303 6511
Ndufc1 244 5855
Ndufc2 1751 5872
Ndufs1 -4600 -3892
Ndufs2 3048 3749
Ndufs3 2649 7121
Ndufs4 -4321 3532
Ndufs5 5544 5353
Ndufs6 2859 6188
Ndufs7 7071 4105
Ndufs8 6562 3002
Ndufv1 5257 6550
Ndufv2 -2331 2392
Ndufv3 1676 3058
Nubpl -2946 3899
Sco1 -3592 -5698
Sco2 6761 -1165
Sdha 1654 -4472
Sdhb 5449 2810
Sdhc 2070 4642
Sdhd 3895 2541
Surf1 5903 6926
Taco1 5039 3904
Timmdc1 6640 6659
Tmem126b 4953 -1177
Tmem186 2751 -7025
Trap1 5260 2654
Uqcr10 5312 5658
Uqcr11 3595 5725
Uqcrb -3797 2944
Uqcrc1 5172 3627
Uqcrc2 -4461 -1103
Uqcrfs1 980 1396
Uqcrh 195 5904
Uqcrq 4846 5949



CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
metric value
setSize 11
pMANOVA 0.059
p.adjustMANOVA 0.195
s.dist 0.488
s.LPS -0.38
s.OVA -0.305
p.LPS 0.029
p.OVA 0.0797




Top 20 genes
Gene LPS OVA
Adcy8 -6499 -8298
Adcy1 -8384 -3295
Prkx -6747 -2680
Prkacb -3491 -3261
Prkar1a -2074 -3761
Prkar2b -7900 -392
Prkar2a -147 -2856

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 -8384 -3295
Adcy8 -6499 -8298
Calm1 -7889 1508
Creb1 -4259 3498
Prkaca 5362 -3517
Prkacb -3491 -3261
Prkar1a -2074 -3761
Prkar1b 5432 -4139
Prkar2a -147 -2856
Prkar2b -7900 -392
Prkx -6747 -2680



CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
metric value
setSize 13
pMANOVA 0.0346
p.adjustMANOVA 0.136
s.dist 0.487
s.LPS 0.386
s.OVA 0.297
p.LPS 0.0159
p.OVA 0.0637




Top 20 genes
Gene LPS OVA
Nubp1 7691 7530
Ciapin1 8015 5562
Pold1 5188 8100
Brip1 4528 7441
Ciao1 6734 4057
Ercc2 6781 3840
Ciao3 4507 4716
Nubp2 3936 4169
Ciao2b 2741 1437

Click HERE to show all gene set members

All member genes
LPS OVA
Abcb7 -7354 -709
Brip1 4528 7441
Ciao1 6734 4057
Ciao2b 2741 1437
Ciao3 4507 4716
Ciapin1 8015 5562
Ercc2 6781 3840
Mms19 3363 -937
Ndor1 -5193 -6275
Nubp1 7691 7530
Nubp2 3936 4169
Pold1 5188 8100
Rtel1 235 -4737



ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
metric value
setSize 10
pMANOVA 0.0795
p.adjustMANOVA 0.234
s.dist 0.484
s.LPS -0.305
s.OVA -0.376
p.LPS 0.0953
p.OVA 0.0396




Top 20 genes
Gene LPS OVA
Aspa -8206 -5669
Got1 -5040 -7182
Asns -4362 -6330
Got2 -2825 -5841
Folh1 -5176 -220
Slc25a12 -181 -4367

Click HERE to show all gene set members

All member genes
LPS OVA
Asns -4362 -6330
Aspa -8206 -5669
Aspg 351 -3276
Folh1 -5176 -220
Got1 -5040 -7182
Got2 -2825 -5841
Naalad2 -3124 1535
Nat8l 1440 -6735
Slc25a12 -181 -4367
Slc25a13 252 7371



SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX

SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
metric value
setSize 13
pMANOVA 0.00923
p.adjustMANOVA 0.0522
s.dist 0.483
s.LPS 0.0845
s.OVA 0.476
p.LPS 0.598
p.OVA 0.00299




Top 20 genes
Gene LPS OVA
Ptgis 8020 8467
Prxl2b 6533 7908
Ptges2 7163 7082
Ptgds 5901 8065
Tbxas1 1710 8385
Ptges 4986 2423

Click HERE to show all gene set members

All member genes
LPS OVA
Cbr1 4847 -38
Hpgd -3166 8003
Hpgds -4808 2074
Prxl2b 6533 7908
Ptgds 5901 8065
Ptges 4986 2423
Ptges2 7163 7082
Ptges3 -673 7373
Ptgis 8020 8467
Ptgr2 -6950 2118
Ptgs1 -7127 155
Ptgs2 -8503 -8167
Tbxas1 1710 8385



STABILIZATION OF P53

STABILIZATION OF P53
metric value
setSize 54
pMANOVA 1.49e-06
p.adjustMANOVA 4.61e-05
s.dist 0.481
s.LPS 0.312
s.OVA 0.366
p.LPS 7.18e-05
p.OVA 3.25e-06




Top 20 genes
Gene LPS OVA
Psmd3 7906 6874
Psmd13 7257 6934
Sem1 6780 7133
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6134
Psmb2 6181 7346
Psme2 5471 8073
Psmb4 6894 6170
Psmc3 6685 6181
Psmc5 6075 6612
Psmd10 5799 6776
Psmb6 6328 5605
Uba52 4571 7320
Psme1 7334 4527
Psmd8 5319 6063
Psmb7 4527 6187
Psmb10 4823 5736
Psmb1 4454 5798
Psmd4 6593 3487

Click HERE to show all gene set members

All member genes
LPS OVA
Atm -5069 284
Chek2 2976 1499
Cop1 1811 8426
Mdm2 118 -6201
Mdm4 -682 1881
Phf20 -2025 -1954
Psma1 -841 5990
Psma2 4136 4577
Psma3 -1199 7147
Psma4 -129 1872
Psma5 5707 3541
Psma6 2305 4518
Psma7 3997 4636
Psmb1 4454 5798
Psmb10 4823 5736
Psmb2 6181 7346
Psmb3 3563 5507
Psmb4 6894 6170
Psmb5 7413 6134
Psmb6 6328 5605
Psmb7 4527 6187
Psmb8 -6833 3639
Psmb9 -7423 903
Psmc1 -2672 1369
Psmc2 4814 429
Psmc3 6685 6181
Psmc4 8055 5833
Psmc5 6075 6612
Psmc6 -5038 -5235
Psmd1 1229 -2030
Psmd10 5799 6776
Psmd11 -2333 825
Psmd12 -4517 -7819
Psmd13 7257 6934
Psmd14 136 6699
Psmd2 4198 -917
Psmd3 7906 6874
Psmd4 6593 3487
Psmd5 1732 -1274
Psmd6 2247 5119
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3345 6663
Psme1 7334 4527
Psme2 5471 8073
Psme3 -86 3238
Psme4 -5571 -2401
Psmf1 -1094 -378
Rps27a 2525 7575
Sem1 6780 7133
Trp53 1188 -2519
Uba52 4571 7320
Ubb 7203 86
Ubc 2605 -7072



SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
metric value
setSize 12
pMANOVA 0.0338
p.adjustMANOVA 0.134
s.dist 0.479
s.LPS 0.205
s.OVA 0.433
p.LPS 0.218
p.OVA 0.00944




Top 20 genes
Gene LPS OVA
Ptgis 8020 8467
Slc27a2 7277 7240
Acot8 7862 6575
Rxra 6327 5358
Hsd3b7 2120 8450
Amacr 5579 2721
Hsd17b4 149 1873

Click HERE to show all gene set members

All member genes
LPS OVA
Acot8 7862 6575
Amacr 5579 2721
Cyp27a1 -104 -4999
Cyp7b1 -1692 7949
Hsd17b4 149 1873
Hsd3b7 2120 8450
Ncoa1 -6486 -2977
Ncoa2 -7277 -2186
Ptgis 8020 8467
Rxra 6327 5358
Scp2 -2167 6887
Slc27a2 7277 7240



MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION
metric value
setSize 93
pMANOVA 1.37e-10
p.adjustMANOVA 7.64e-09
s.dist 0.478
s.LPS 0.313
s.OVA 0.362
p.LPS 1.92e-07
p.OVA 1.67e-09




Top 20 genes
Gene LPS OVA
Mrps35 7770 8113
Eral1 7602 8170
Mrps6 7465 7758
Mrpl9 7432 7658
Mrpl14 7719 7230
Mrpl23 6316 8302
Mrpl36 6877 6626
Mrpl52 5904 7357
Mrps9 6260 6764
Mrpl4 7101 5738
Mrpl43 6958 5475
Mrpl12 6035 5939
Mrpl51 4312 8239
Mrpl37 5963 5911
Mrpl34 5986 5590
Mrps27 7380 4451
Tufm 7384 4428
Chchd1 4810 6700
Mrpl53 4890 6245
Mrps7 5971 5105

Click HERE to show all gene set members

All member genes
LPS OVA
Aurkaip1 5768 4923
Chchd1 4810 6700
Dap3 -1393 5795
Eral1 7602 8170
Gadd45gip1 7336 2899
Gfm1 -7112 -4211
Gfm2 1994 2075
Mrpl1 -7734 -7637
Mrpl10 169 -1199
Mrpl11 3821 6007
Mrpl12 6035 5939
Mrpl13 599 3040
Mrpl14 7719 7230
Mrpl15 782 4756
Mrpl16 646 7056
Mrpl17 3402 4614
Mrpl18 4865 2590
Mrpl19 2705 -1438
Mrpl2 3450 4348
Mrpl20 3055 4373
Mrpl21 3234 3815
Mrpl22 1328 -3361
Mrpl23 6316 8302
Mrpl24 4327 5620
Mrpl27 6158 3652
Mrpl28 5345 5699
Mrpl3 -3684 1949
Mrpl30 397 2532
Mrpl32 -5626 6960
Mrpl33 -1849 4929
Mrpl34 5986 5590
Mrpl35 2184 6733
Mrpl36 6877 6626
Mrpl37 5963 5911
Mrpl38 7754 259
Mrpl39 1339 -821
Mrpl4 7101 5738
Mrpl40 3526 701
Mrpl41 1539 5502
Mrpl42 1958 4669
Mrpl43 6958 5475
Mrpl44 -4394 -3166
Mrpl46 4613 5356
Mrpl47 -2214 7050
Mrpl48 -490 4617
Mrpl49 5051 537
Mrpl50 -5580 1031
Mrpl51 4312 8239
Mrpl52 5904 7357
Mrpl53 4890 6245
Mrpl54 3075 4678
Mrpl55 -410 -4896
Mrpl57 4097 4717
Mrpl58 4490 2007
Mrpl9 7432 7658
Mrps10 -3651 236
Mrps11 6165 2179
Mrps12 7312 628
Mrps14 -2871 4576
Mrps15 1131 6285
Mrps16 362 4866
Mrps17 1988 6322
Mrps18a 3715 791
Mrps18b -1817 1871
Mrps18c 1138 6582
Mrps2 -3568 -721
Mrps21 2685 4504
Mrps22 3948 2100
Mrps23 3497 6178
Mrps24 3115 3766
Mrps25 1635 1322
Mrps26 6384 3709
Mrps27 7380 4451
Mrps28 3957 449
Mrps30 4797 5682
Mrps31 -1648 -7096
Mrps33 1426 4427
Mrps34 7082 3931
Mrps35 7770 8113
Mrps36 -5480 115
Mrps5 -3954 -6845
Mrps6 7465 7758
Mrps7 5971 5105
Mrps9 6260 6764
Mrrf 7589 -1578
Mtfmt 2478 2738
Mtif2 -3906 54
Mtif3 -1446 -4339
Mtrf1l 3451 2371
Oxa1l 4575 3759
Ptcd3 -6181 -8001
Tsfm 2670 2708
Tufm 7384 4428



WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
metric value
setSize 13
pMANOVA 0.00834
p.adjustMANOVA 0.0488
s.dist 0.474
s.LPS 0.471
s.OVA 0.0516
p.LPS 0.00326
p.OVA 0.747




Top 20 genes
Gene LPS OVA
Fzd2 7758 8457
Cltb 7548 5245
Fzd5 6159 5840
Clta 6828 5242
Ap2s1 6318 2502
Ror1 2836 4913

Click HERE to show all gene set members

All member genes
LPS OVA
Ap2a1 6603 -1071
Ap2a2 4266 -3195
Ap2b1 -2179 -4661
Ap2m1 6014 -2521
Ap2s1 6318 2502
Clta 6828 5242
Cltb 7548 5245
Cltc -5075 -3631
Fzd2 7758 8457
Fzd5 6159 5840
Ror1 2836 4913
Ror2 917 -2604
Wnt5a 2534 -7354



CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND

CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
metric value
setSize 10
pMANOVA 0.052
p.adjustMANOVA 0.178
s.dist 0.472
s.LPS -0.16
s.OVA -0.444
p.LPS 0.381
p.OVA 0.0151




Top 20 genes
Gene LPS OVA
Unc5b -7479 -8146
Appl1 -6322 -4298
Casp9 -5913 -3501
Dcc -8429 -1794
Dapk2 -1376 -5665
Casp3 -2336 -1371
Dapk1 -78 -3649

Click HERE to show all gene set members

All member genes
LPS OVA
Appl1 -6322 -4298
Casp3 -2336 -1371
Casp9 -5913 -3501
Dapk1 -78 -3649
Dapk2 -1376 -5665
Dapk3 7759 3984
Dcc -8429 -1794
Maged1 5937 -3837
Unc5a 3624 -8171
Unc5b -7479 -8146



THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT

THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT
metric value
setSize 66
pMANOVA 8.94e-08
p.adjustMANOVA 4.04e-06
s.dist 0.47
s.LPS 0.389
s.OVA 0.264
p.LPS 4.7e-08
p.OVA 0.000214




Top 20 genes
Gene LPS OVA
Psmd3 7906 6874
Tuba1a 7803 6914
Tuba1b 7786 6589
Psmd13 7257 6934
Sem1 6780 7133
Psmd7 8072 5831
Psmc4 8055 5833
Psmb5 7413 6134
Psmb2 6181 7346
Psme2 5471 8073
Psmb4 6894 6170
Psmc3 6685 6181
Psmc5 6075 6612
Psmd10 5799 6776
Tubb6 7355 4840
Psmb6 6328 5605
Uba52 4571 7320
Psme1 7334 4527
Psmd8 5319 6063
Psmb7 4527 6187

Click HERE to show all gene set members

All member genes
LPS OVA
Ccnb2 4070 6503
Cdkn1a 2157 -4363
Fkbpl -3815 -4444
Hsp90aa1 -7542 -7941
Hsp90ab1 1993 -6841
Mapre1 -5354 5561
Plk1 6266 -7977
Psma1 -841 5990
Psma2 4136 4577
Psma3 -1199 7147
Psma4 -129 1872
Psma5 5707 3541
Psma6 2305 4518
Psma7 3997 4636
Psmb1 4454 5798
Psmb10 4823 5736
Psmb2 6181 7346
Psmb3 3563 5507
Psmb4 6894 6170
Psmb5 7413 6134
Psmb6 6328 5605
Psmb7 4527 6187
Psmb8 -6833 3639
Psmb9 -7423 903
Psmc1 -2672 1369
Psmc2 4814 429
Psmc3 6685 6181
Psmc4 8055 5833
Psmc5 6075 6612
Psmc6 -5038 -5235
Psmd1 1229 -2030
Psmd10 5799 6776
Psmd11 -2333 825
Psmd12 -4517 -7819
Psmd13 7257 6934
Psmd14 136 6699
Psmd2 4198 -917
Psmd3 7906 6874
Psmd4 6593 3487
Psmd5 1732 -1274
Psmd6 2247 5119
Psmd7 8072 5831
Psmd8 5319 6063
Psmd9 3345 6663
Psme1 7334 4527
Psme2 5471 8073
Psme3 -86 3238
Psme4 -5571 -2401
Psmf1 -1094 -378
Rps27a 2525 7575
Sem1 6780 7133
Trp53 1188 -2519
Tuba1a 7803 6914
Tuba1b 7786 6589
Tuba1c 2923 6641
Tuba4a 5110 -5122
Tuba8 4697 -6669
Tubb2a 7932 1275
Tubb2b 6404 -908
Tubb3 7161 -4850
Tubb4a 7131 -5162
Tubb4b 7939 1028
Tubb6 7355 4840
Uba52 4571 7320
Ubb 7203 86
Ubc 2605 -7072



GLUTATHIONE SYNTHESIS AND RECYCLING

GLUTATHIONE SYNTHESIS AND RECYCLING
metric value
setSize 11
pMANOVA 0.0724
p.adjustMANOVA 0.221
s.dist 0.468
s.LPS 0.285
s.OVA 0.371
p.LPS 0.102
p.OVA 0.033




Top 20 genes
Gene LPS OVA
Oplah 8182 8274
Cndp2 6183 7885
Gss 6638 7248
Ggt1 5047 4887
Chac1 7841 913

Click HERE to show all gene set members

All member genes
LPS OVA
Chac1 7841 913
Chac2 -2450 -1913
Cndp2 6183 7885
Gclc -3282 -4187
Gclm -5387 1210
Ggct -624 7253
Ggt1 5047 4887
Ggt5 -47 7071
Ggt7 3280 -2796
Gss 6638 7248
Oplah 8182 8274



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report