Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2024-04-04
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
| LPS | OVA | |
|---|---|---|
| 0610009B22Rik | -0.3304181 | 0.0972207 |
| 0610009E02Rik | 0.7596333 | 1.2632625 |
| 0610009L18Rik | -1.2521412 | -0.6637497 |
| 0610010K14Rik | 0.4193627 | -0.4536898 |
| 0610012G03Rik | 1.4462155 | 0.1223624 |
| 0610030E20Rik | -0.2426628 | -0.0456229 |
Here are some metrics about the input data profile:
| Profile metrics | |
|---|---|
| num_genes_in_profile | 16956 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8348 |
| num_profile_genes_not_in_sets | 8608 |
| profile_pearson_correl | 0.42429 |
| profile_spearman_correl | 0.40715 |
Here is a plot of the input profiles. Note the dynamic ranges.
Here is the contour plot of the profile including all detected genes.
Input genesets
Here are some metrics about the gene sets used:
GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 1604 |
| num_genesets_excluded | 429 |
| num_genesets_included | 1175 |
Gene sets by quadrant
Number of significant gene sets (FDR<0.05)= 205 
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.LPS | s.OVA | p.LPS | p.OVA |
|---|---|---|---|---|---|---|---|---|
| ENDOSOMAL VACUOLAR PATHWAY | 11 | 1.92e-04 | 2.40e-03 | 0.567 | -0.27600 | 0.49600 | 1.13e-01 | 4.43e-03 |
| POST CHAPERONIN TUBULIN FOLDING PATHWAY | 17 | 5.32e-06 | 1.30e-04 | 0.629 | 0.62900 | -0.00377 | 7.12e-06 | 9.79e-01 |
| NUCLEOTIDE LIKE PURINERGIC RECEPTORS | 13 | 2.73e-03 | 2.00e-02 | 0.424 | -0.31400 | 0.28500 | 4.98e-02 | 7.55e-02 |
| REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM | 11 | 8.61e-03 | 4.95e-02 | 0.424 | 0.20100 | -0.37300 | 2.48e-01 | 3.23e-02 |
| CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN | 36 | 1.11e-06 | 3.72e-05 | 0.415 | 0.39700 | -0.12300 | 3.81e-05 | 2.02e-01 |
| CYTOSOLIC TRNA AMINOACYLATION | 24 | 4.58e-04 | 5.03e-03 | 0.375 | 0.35200 | -0.13100 | 2.87e-03 | 2.66e-01 |
| YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 11 | 1.51e-03 | 1.27e-02 | 0.633 | 0.14400 | 0.61600 | 4.08e-01 | 3.99e-04 |
| TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE | 13 | 7.83e-04 | 7.87e-03 | 0.604 | 0.59200 | 0.12200 | 2.21e-04 | 4.47e-01 |
| EUKARYOTIC TRANSLATION ELONGATION | 87 | 3.42e-33 | 2.01e-30 | 0.815 | 0.30100 | 0.75700 | 1.28e-06 | 2.23e-34 |
| G BETA GAMMA SIGNALLING THROUGH CDC42 | 18 | 7.39e-03 | 4.41e-02 | 0.342 | -0.13800 | 0.31300 | 3.12e-01 | 2.17e-02 |
| RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY | 95 | 3.32e-27 | 7.79e-25 | 0.690 | 0.22200 | 0.65300 | 1.82e-04 | 3.29e-28 |
| EUKARYOTIC TRANSLATION INITIATION | 114 | 1.91e-30 | 5.61e-28 | 0.663 | 0.20400 | 0.63100 | 1.64e-04 | 2.28e-31 |
| ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 59 | 3.21e-14 | 2.52e-12 | 0.609 | 0.16200 | 0.58700 | 3.14e-02 | 6.06e-15 |
| SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 106 | 2.33e-32 | 9.14e-30 | 0.723 | 0.25400 | 0.67700 | 6.23e-06 | 1.67e-33 |
| WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 | 13 | 8.32e-03 | 4.87e-02 | 0.474 | 0.47100 | 0.05160 | 3.26e-03 | 7.47e-01 |
| FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 18 | 2.61e-04 | 3.06e-03 | 0.557 | 0.12500 | 0.54300 | 3.58e-01 | 6.65e-05 |
| ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 | 19 | 8.62e-03 | 4.95e-02 | 0.343 | -0.07930 | 0.33400 | 5.50e-01 | 1.18e-02 |
| IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | 48 | 4.41e-06 | 1.13e-04 | 0.354 | -0.06230 | 0.34900 | 4.56e-01 | 2.91e-05 |
| SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III | 23 | 7.54e-05 | 1.14e-03 | 0.523 | 0.51200 | 0.10400 | 2.12e-05 | 3.88e-01 |
| GLYCOLYSIS | 66 | 1.37e-06 | 4.34e-05 | 0.296 | 0.12100 | -0.27000 | 8.95e-02 | 1.49e-04 |
| AGGREPHAGY | 35 | 7.03e-05 | 1.07e-03 | 0.395 | 0.39400 | 0.01100 | 5.37e-05 | 9.10e-01 |
| FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 19 | 6.42e-05 | 1.01e-03 | 0.614 | 0.58100 | 0.19900 | 1.17e-05 | 1.32e-01 |
| RHO GTPASES ACTIVATE WASPS AND WAVES | 36 | 1.43e-04 | 1.88e-03 | 0.368 | -0.36800 | 0.00628 | 1.35e-04 | 9.48e-01 |
| GLUCOSE METABOLISM | 80 | 7.56e-07 | 2.96e-05 | 0.269 | 0.13700 | -0.23200 | 3.48e-02 | 3.31e-04 |
| REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO | 10 | 2.91e-03 | 2.09e-02 | 0.676 | -0.26000 | -0.62400 | 1.55e-01 | 6.32e-04 |
| INTERFERON ALPHA BETA SIGNALING | 55 | 1.04e-04 | 1.49e-03 | 0.257 | -0.18300 | 0.18000 | 1.86e-02 | 2.09e-02 |
| G PROTEIN ACTIVATION | 22 | 3.33e-03 | 2.35e-02 | 0.391 | 0.02750 | 0.39000 | 8.23e-01 | 1.53e-03 |
| THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 22 | 3.83e-03 | 2.61e-02 | 0.387 | 0.02770 | 0.38600 | 8.22e-01 | 1.74e-03 |
| SEROTONIN NEUROTRANSMITTER RELEASE CYCLE | 18 | 9.57e-04 | 9.02e-03 | 0.528 | -0.15500 | -0.50500 | 2.54e-01 | 2.10e-04 |
| HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR | 48 | 1.26e-04 | 1.70e-03 | 0.304 | 0.30000 | -0.04880 | 3.23e-04 | 5.59e-01 |
| GAP JUNCTION ASSEMBLY | 21 | 1.86e-03 | 1.49e-02 | 0.445 | 0.43600 | 0.08800 | 5.40e-04 | 4.85e-01 |
| CGMP EFFECTS | 15 | 8.01e-04 | 7.98e-03 | 0.604 | -0.56300 | -0.22000 | 1.60e-04 | 1.41e-01 |
| SELENOAMINO ACID METABOLISM | 109 | 1.35e-24 | 2.27e-22 | 0.629 | 0.24100 | 0.58100 | 1.42e-05 | 1.02e-25 |
| COLLAGEN CHAIN TRIMERIZATION | 40 | 2.22e-03 | 1.69e-02 | 0.254 | 0.11200 | -0.22800 | 2.22e-01 | 1.26e-02 |
| ARACHIDONIC ACID METABOLISM | 38 | 4.77e-04 | 5.15e-03 | 0.333 | -0.00562 | 0.33300 | 9.52e-01 | 3.89e-04 |
| GLUTATHIONE CONJUGATION | 29 | 1.88e-04 | 2.39e-03 | 0.448 | 0.10100 | 0.43700 | 3.44e-01 | 4.72e-05 |
| COMPLEX I BIOGENESIS | 56 | 1.08e-10 | 6.36e-09 | 0.557 | 0.19100 | 0.52300 | 1.33e-02 | 1.31e-11 |
| NONSENSE MEDIATED DECAY NMD | 109 | 1.73e-20 | 2.25e-18 | 0.564 | 0.19700 | 0.52800 | 3.76e-04 | 1.52e-21 |
| CA2 PATHWAY | 57 | 2.60e-04 | 3.06e-03 | 0.251 | -0.23400 | 0.09250 | 2.28e-03 | 2.27e-01 |
| BRANCHED CHAIN AMINO ACID CATABOLISM | 21 | 3.87e-03 | 2.61e-02 | 0.419 | 0.08450 | 0.41000 | 5.03e-01 | 1.13e-03 |
| NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | 20 | 3.35e-04 | 3.82e-03 | 0.553 | -0.51600 | -0.19800 | 6.36e-05 | 1.25e-01 |
| SIGNAL AMPLIFICATION | 30 | 6.13e-03 | 3.79e-02 | 0.301 | -0.01590 | 0.30100 | 8.80e-01 | 4.36e-03 |
| INTERFERON GAMMA SIGNALING | 77 | 3.57e-05 | 5.99e-04 | 0.239 | -0.21800 | 0.09790 | 9.67e-04 | 1.38e-01 |
| RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 125 | 2.59e-18 | 3.04e-16 | 0.492 | 0.16000 | 0.46500 | 2.00e-03 | 2.74e-19 |
| RESPIRATORY ELECTRON TRANSPORT | 102 | 6.65e-15 | 6.51e-13 | 0.489 | 0.16000 | 0.46200 | 5.30e-03 | 7.49e-16 |
| DETOXIFICATION OF REACTIVE OXYGEN SPECIES | 33 | 7.35e-04 | 7.51e-03 | 0.379 | 0.07250 | 0.37200 | 4.71e-01 | 2.16e-04 |
| NCAM1 INTERACTIONS | 41 | 2.92e-03 | 2.09e-02 | 0.271 | 0.02750 | -0.26900 | 7.61e-01 | 2.84e-03 |
| TRNA AMINOACYLATION | 42 | 1.13e-03 | 1.01e-02 | 0.303 | 0.30300 | 0.00830 | 6.71e-04 | 9.26e-01 |
| COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES | 62 | 6.51e-04 | 6.77e-03 | 0.234 | 0.22600 | -0.06090 | 2.08e-03 | 4.07e-01 |
| FOXO MEDIATED TRANSCRIPTION | 58 | 2.60e-03 | 1.95e-02 | 0.202 | -0.15400 | 0.13100 | 4.21e-02 | 8.57e-02 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.LPS | s.OVA | p.LPS | p.OVA |
|---|---|---|---|---|---|---|---|---|
| ENDOSOMAL VACUOLAR PATHWAY | 11 | 1.92e-04 | 2.40e-03 | 0.5670 | -0.276000 | 0.496000 | 1.13e-01 | 4.43e-03 |
| POST CHAPERONIN TUBULIN FOLDING PATHWAY | 17 | 5.32e-06 | 1.30e-04 | 0.6290 | 0.629000 | -0.003770 | 7.12e-06 | 9.79e-01 |
| NUCLEOTIDE LIKE PURINERGIC RECEPTORS | 13 | 2.73e-03 | 2.00e-02 | 0.4240 | -0.314000 | 0.285000 | 4.98e-02 | 7.55e-02 |
| REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM | 11 | 8.61e-03 | 4.95e-02 | 0.4240 | 0.201000 | -0.373000 | 2.48e-01 | 3.23e-02 |
| CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN | 36 | 1.11e-06 | 3.72e-05 | 0.4150 | 0.397000 | -0.123000 | 3.81e-05 | 2.02e-01 |
| CYTOSOLIC TRNA AMINOACYLATION | 24 | 4.58e-04 | 5.03e-03 | 0.3750 | 0.352000 | -0.131000 | 2.87e-03 | 2.66e-01 |
| YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 11 | 1.51e-03 | 1.27e-02 | 0.6330 | 0.144000 | 0.616000 | 4.08e-01 | 3.99e-04 |
| TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE | 13 | 7.83e-04 | 7.87e-03 | 0.6040 | 0.592000 | 0.122000 | 2.21e-04 | 4.47e-01 |
| EUKARYOTIC TRANSLATION ELONGATION | 87 | 3.42e-33 | 2.01e-30 | 0.8150 | 0.301000 | 0.757000 | 1.28e-06 | 2.23e-34 |
| G BETA GAMMA SIGNALLING THROUGH CDC42 | 18 | 7.39e-03 | 4.41e-02 | 0.3420 | -0.138000 | 0.313000 | 3.12e-01 | 2.17e-02 |
| RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY | 95 | 3.32e-27 | 7.79e-25 | 0.6900 | 0.222000 | 0.653000 | 1.82e-04 | 3.29e-28 |
| EUKARYOTIC TRANSLATION INITIATION | 114 | 1.91e-30 | 5.61e-28 | 0.6630 | 0.204000 | 0.631000 | 1.64e-04 | 2.28e-31 |
| ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 59 | 3.21e-14 | 2.52e-12 | 0.6090 | 0.162000 | 0.587000 | 3.14e-02 | 6.06e-15 |
| SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 106 | 2.33e-32 | 9.14e-30 | 0.7230 | 0.254000 | 0.677000 | 6.23e-06 | 1.67e-33 |
| WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 | 13 | 8.32e-03 | 4.87e-02 | 0.4740 | 0.471000 | 0.051600 | 3.26e-03 | 7.47e-01 |
| FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 18 | 2.61e-04 | 3.06e-03 | 0.5570 | 0.125000 | 0.543000 | 3.58e-01 | 6.65e-05 |
| ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 | 19 | 8.62e-03 | 4.95e-02 | 0.3430 | -0.079300 | 0.334000 | 5.50e-01 | 1.18e-02 |
| IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | 48 | 4.41e-06 | 1.13e-04 | 0.3540 | -0.062300 | 0.349000 | 4.56e-01 | 2.91e-05 |
| SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III | 23 | 7.54e-05 | 1.14e-03 | 0.5230 | 0.512000 | 0.104000 | 2.12e-05 | 3.88e-01 |
| GLYCOLYSIS | 66 | 1.37e-06 | 4.34e-05 | 0.2960 | 0.121000 | -0.270000 | 8.95e-02 | 1.49e-04 |
| AGGREPHAGY | 35 | 7.03e-05 | 1.07e-03 | 0.3950 | 0.394000 | 0.011000 | 5.37e-05 | 9.10e-01 |
| FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 19 | 6.42e-05 | 1.01e-03 | 0.6140 | 0.581000 | 0.199000 | 1.17e-05 | 1.32e-01 |
| RHO GTPASES ACTIVATE WASPS AND WAVES | 36 | 1.43e-04 | 1.88e-03 | 0.3680 | -0.368000 | 0.006280 | 1.35e-04 | 9.48e-01 |
| GLUCOSE METABOLISM | 80 | 7.56e-07 | 2.96e-05 | 0.2690 | 0.137000 | -0.232000 | 3.48e-02 | 3.31e-04 |
| REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO | 10 | 2.91e-03 | 2.09e-02 | 0.6760 | -0.260000 | -0.624000 | 1.55e-01 | 6.32e-04 |
| INTERFERON ALPHA BETA SIGNALING | 55 | 1.04e-04 | 1.49e-03 | 0.2570 | -0.183000 | 0.180000 | 1.86e-02 | 2.09e-02 |
| G PROTEIN ACTIVATION | 22 | 3.33e-03 | 2.35e-02 | 0.3910 | 0.027500 | 0.390000 | 8.23e-01 | 1.53e-03 |
| THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 22 | 3.83e-03 | 2.61e-02 | 0.3870 | 0.027700 | 0.386000 | 8.22e-01 | 1.74e-03 |
| SEROTONIN NEUROTRANSMITTER RELEASE CYCLE | 18 | 9.57e-04 | 9.02e-03 | 0.5280 | -0.155000 | -0.505000 | 2.54e-01 | 2.10e-04 |
| HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR | 48 | 1.26e-04 | 1.70e-03 | 0.3040 | 0.300000 | -0.048800 | 3.23e-04 | 5.59e-01 |
| GAP JUNCTION ASSEMBLY | 21 | 1.86e-03 | 1.49e-02 | 0.4450 | 0.436000 | 0.088000 | 5.40e-04 | 4.85e-01 |
| CGMP EFFECTS | 15 | 8.01e-04 | 7.98e-03 | 0.6040 | -0.563000 | -0.220000 | 1.60e-04 | 1.41e-01 |
| SELENOAMINO ACID METABOLISM | 109 | 1.35e-24 | 2.27e-22 | 0.6290 | 0.241000 | 0.581000 | 1.42e-05 | 1.02e-25 |
| COLLAGEN CHAIN TRIMERIZATION | 40 | 2.22e-03 | 1.69e-02 | 0.2540 | 0.112000 | -0.228000 | 2.22e-01 | 1.26e-02 |
| ARACHIDONIC ACID METABOLISM | 38 | 4.77e-04 | 5.15e-03 | 0.3330 | -0.005620 | 0.333000 | 9.52e-01 | 3.89e-04 |
| GLUTATHIONE CONJUGATION | 29 | 1.88e-04 | 2.39e-03 | 0.4480 | 0.101000 | 0.437000 | 3.44e-01 | 4.72e-05 |
| COMPLEX I BIOGENESIS | 56 | 1.08e-10 | 6.36e-09 | 0.5570 | 0.191000 | 0.523000 | 1.33e-02 | 1.31e-11 |
| NONSENSE MEDIATED DECAY NMD | 109 | 1.73e-20 | 2.25e-18 | 0.5640 | 0.197000 | 0.528000 | 3.76e-04 | 1.52e-21 |
| CA2 PATHWAY | 57 | 2.60e-04 | 3.06e-03 | 0.2510 | -0.234000 | 0.092500 | 2.28e-03 | 2.27e-01 |
| BRANCHED CHAIN AMINO ACID CATABOLISM | 21 | 3.87e-03 | 2.61e-02 | 0.4190 | 0.084500 | 0.410000 | 5.03e-01 | 1.13e-03 |
| NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | 20 | 3.35e-04 | 3.82e-03 | 0.5530 | -0.516000 | -0.198000 | 6.36e-05 | 1.25e-01 |
| SIGNAL AMPLIFICATION | 30 | 6.13e-03 | 3.79e-02 | 0.3010 | -0.015900 | 0.301000 | 8.80e-01 | 4.36e-03 |
| INTERFERON GAMMA SIGNALING | 77 | 3.57e-05 | 5.99e-04 | 0.2390 | -0.218000 | 0.097900 | 9.67e-04 | 1.38e-01 |
| RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 125 | 2.59e-18 | 3.04e-16 | 0.4920 | 0.160000 | 0.465000 | 2.00e-03 | 2.74e-19 |
| RESPIRATORY ELECTRON TRANSPORT | 102 | 6.65e-15 | 6.51e-13 | 0.4890 | 0.160000 | 0.462000 | 5.30e-03 | 7.49e-16 |
| DETOXIFICATION OF REACTIVE OXYGEN SPECIES | 33 | 7.35e-04 | 7.51e-03 | 0.3790 | 0.072500 | 0.372000 | 4.71e-01 | 2.16e-04 |
| NCAM1 INTERACTIONS | 41 | 2.92e-03 | 2.09e-02 | 0.2710 | 0.027500 | -0.269000 | 7.61e-01 | 2.84e-03 |
| TRNA AMINOACYLATION | 42 | 1.13e-03 | 1.01e-02 | 0.3030 | 0.303000 | 0.008300 | 6.71e-04 | 9.26e-01 |
| COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES | 62 | 6.51e-04 | 6.77e-03 | 0.2340 | 0.226000 | -0.060900 | 2.08e-03 | 4.07e-01 |
| FOXO MEDIATED TRANSCRIPTION | 58 | 2.60e-03 | 1.95e-02 | 0.2020 | -0.154000 | 0.131000 | 4.21e-02 | 8.57e-02 |
| COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC | 44 | 5.13e-03 | 3.28e-02 | 0.2390 | 0.233000 | -0.051100 | 7.40e-03 | 5.58e-01 |
| PARASITE INFECTION | 55 | 4.30e-04 | 4.82e-03 | 0.2780 | -0.278000 | 0.006180 | 3.67e-04 | 9.37e-01 |
| IRE1ALPHA ACTIVATES CHAPERONES | 50 | 2.14e-06 | 5.85e-05 | 0.4370 | 0.416000 | 0.134000 | 3.62e-07 | 1.01e-01 |
| CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | 12 | 8.63e-03 | 4.95e-02 | 0.5640 | -0.234000 | -0.513000 | 1.60e-01 | 2.08e-03 |
| RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | 85 | 2.32e-04 | 2.85e-03 | 0.2070 | 0.078500 | -0.191000 | 2.11e-01 | 2.30e-03 |
| INTRAFLAGELLAR TRANSPORT | 51 | 9.69e-06 | 2.00e-04 | 0.4040 | 0.386000 | 0.117000 | 1.80e-06 | 1.48e-01 |
| TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS | 41 | 3.04e-04 | 3.54e-03 | 0.3690 | -0.090100 | -0.358000 | 3.18e-01 | 7.27e-05 |
| REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 29 | 7.19e-04 | 7.41e-03 | 0.4310 | -0.140000 | -0.407000 | 1.92e-01 | 1.47e-04 |
| MITOCHONDRIAL FATTY ACID BETA OXIDATION | 34 | 1.35e-04 | 1.80e-03 | 0.4450 | 0.153000 | 0.418000 | 1.23e-01 | 2.47e-05 |
| ANTIGEN PROCESSING CROSS PRESENTATION | 97 | 2.13e-11 | 1.32e-09 | 0.4370 | 0.148000 | 0.411000 | 1.20e-02 | 2.55e-12 |
| EXTRA NUCLEAR ESTROGEN SIGNALING | 67 | 2.04e-03 | 1.62e-02 | 0.2010 | -0.187000 | 0.073200 | 8.03e-03 | 3.00e-01 |
| COPI MEDIATED ANTEROGRADE TRANSPORT | 91 | 1.19e-04 | 1.63e-03 | 0.2170 | 0.212000 | -0.048200 | 4.84e-04 | 4.27e-01 |
| RET SIGNALING | 37 | 7.74e-03 | 4.59e-02 | 0.2780 | -0.017300 | -0.277000 | 8.56e-01 | 3.53e-03 |
| REGULATION OF EXPRESSION OF SLITS AND ROBOS | 160 | 4.23e-24 | 6.21e-22 | 0.5210 | 0.216000 | 0.474000 | 2.42e-06 | 3.75e-25 |
| CRISTAE FORMATION | 31 | 9.79e-04 | 9.13e-03 | 0.4080 | 0.132000 | 0.385000 | 2.02e-01 | 2.04e-04 |
| CELLULAR RESPONSE TO STARVATION | 146 | 2.48e-17 | 2.65e-15 | 0.4510 | 0.167000 | 0.419000 | 5.16e-04 | 2.25e-18 |
| INFLUENZA INFECTION | 145 | 3.40e-13 | 2.35e-11 | 0.3820 | 0.118000 | 0.363000 | 1.45e-02 | 4.47e-14 |
| EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS | 31 | 4.77e-04 | 5.15e-03 | 0.4390 | -0.168000 | -0.406000 | 1.05e-01 | 9.20e-05 |
| COLLAGEN FORMATION | 79 | 1.71e-03 | 1.41e-02 | 0.1950 | 0.190000 | -0.044500 | 3.49e-03 | 4.94e-01 |
| THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 172 | 2.56e-13 | 1.88e-11 | 0.3500 | 0.102000 | 0.335000 | 2.16e-02 | 3.83e-14 |
| METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES | 21 | 5.38e-03 | 3.38e-02 | 0.4440 | 0.176000 | 0.407000 | 1.62e-01 | 1.23e-03 |
| AURKA ACTIVATION BY TPX2 | 71 | 8.37e-04 | 8.09e-03 | 0.2410 | -0.011100 | -0.240000 | 8.72e-01 | 4.64e-04 |
| ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE | 96 | 1.44e-03 | 1.23e-02 | 0.1730 | 0.063400 | -0.161000 | 2.83e-01 | 6.56e-03 |
| PHASE II CONJUGATION OF COMPOUNDS | 61 | 9.45e-04 | 9.02e-03 | 0.2700 | 0.043100 | 0.267000 | 5.60e-01 | 3.13e-04 |
| RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 78 | 1.20e-03 | 1.06e-02 | 0.2170 | 0.007240 | -0.216000 | 9.12e-01 | 9.53e-04 |
| REDUCTION OF CYTOSOLIC CA LEVELS | 11 | 4.74e-03 | 3.08e-02 | 0.6500 | -0.557000 | -0.336000 | 1.38e-03 | 5.39e-02 |
| INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | 34 | 1.09e-03 | 9.94e-03 | 0.3950 | -0.150000 | -0.366000 | 1.31e-01 | 2.21e-04 |
| NUCLEAR IMPORT OF REV PROTEIN | 32 | 1.35e-03 | 1.16e-02 | 0.4030 | -0.156000 | -0.371000 | 1.26e-01 | 2.79e-04 |
| NCAM SIGNALING FOR NEURITE OUT GROWTH | 61 | 6.50e-03 | 3.96e-02 | 0.2150 | 0.000121 | -0.215000 | 9.99e-01 | 3.76e-03 |
| FATTY ACID METABOLISM | 145 | 1.45e-07 | 5.87e-06 | 0.2680 | 0.051900 | 0.263000 | 2.81e-01 | 4.51e-08 |
| REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION | 85 | 2.62e-03 | 1.95e-02 | 0.1910 | 0.017200 | -0.190000 | 7.85e-01 | 2.46e-03 |
| INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS | 35 | 1.73e-03 | 1.41e-02 | 0.3770 | -0.144000 | -0.348000 | 1.42e-01 | 3.61e-04 |
| RAC3 GTPASE CYCLE | 89 | 5.35e-03 | 3.38e-02 | 0.1650 | -0.160000 | 0.042000 | 9.09e-03 | 4.94e-01 |
| CILIUM ASSEMBLY | 191 | 1.40e-05 | 2.74e-04 | 0.1660 | 0.161000 | -0.040900 | 1.29e-04 | 3.30e-01 |
| SIGNALING BY ROBO RECEPTORS | 205 | 2.18e-14 | 1.86e-12 | 0.3450 | 0.126000 | 0.321000 | 1.82e-03 | 2.17e-15 |
| PEROXISOMAL PROTEIN IMPORT | 57 | 2.12e-03 | 1.65e-02 | 0.2760 | 0.074000 | 0.266000 | 3.34e-01 | 5.11e-04 |
| NUCLEAR PORE COMPLEX NPC DISASSEMBLY | 32 | 8.18e-04 | 8.08e-03 | 0.4290 | -0.192000 | -0.383000 | 6.03e-02 | 1.76e-04 |
| UNFOLDED PROTEIN RESPONSE UPR | 86 | 2.53e-04 | 3.03e-03 | 0.2560 | 0.250000 | 0.058600 | 6.36e-05 | 3.48e-01 |
| BIOLOGICAL OXIDATIONS | 125 | 9.58e-07 | 3.31e-05 | 0.2830 | 0.082400 | 0.271000 | 1.12e-01 | 1.68e-07 |
| DEGRADATION OF THE EXTRACELLULAR MATRIX | 107 | 6.85e-03 | 4.15e-02 | 0.1430 | 0.052400 | -0.133000 | 3.49e-01 | 1.77e-02 |
| ER TO GOLGI ANTEROGRADE TRANSPORT | 142 | 1.32e-03 | 1.16e-02 | 0.1450 | 0.139000 | -0.044500 | 4.41e-03 | 3.61e-01 |
| INTERFERON SIGNALING | 164 | 1.52e-05 | 2.93e-04 | 0.2030 | -0.202000 | -0.019400 | 8.26e-06 | 6.69e-01 |
| TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA | 34 | 5.05e-03 | 3.24e-02 | 0.3510 | -0.140000 | -0.322000 | 1.58e-01 | 1.15e-03 |
| SUMOYLATION OF SUMOYLATION PROTEINS | 33 | 8.40e-04 | 8.09e-03 | 0.4230 | -0.195000 | -0.376000 | 5.24e-02 | 1.87e-04 |
| TRANSCRIPTIONAL REGULATION BY MECP2 | 59 | 1.67e-03 | 1.38e-02 | 0.2820 | -0.268000 | -0.087700 | 3.67e-04 | 2.44e-01 |
| COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC | 86 | 4.05e-03 | 2.72e-02 | 0.1960 | 0.195000 | 0.016100 | 1.76e-03 | 7.96e-01 |
| SELECTIVE AUTOPHAGY | 72 | 4.69e-03 | 3.08e-02 | 0.2210 | 0.217000 | 0.042100 | 1.43e-03 | 5.37e-01 |
| DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | 23 | 7.94e-03 | 4.69e-02 | 0.4210 | -0.371000 | -0.199000 | 2.08e-03 | 9.81e-02 |
| PHASE I FUNCTIONALIZATION OF COMPOUNDS | 61 | 1.34e-03 | 1.16e-02 | 0.2870 | 0.099200 | 0.269000 | 1.80e-01 | 2.79e-04 |
| TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | 171 | 1.50e-03 | 1.27e-02 | 0.1290 | 0.120000 | -0.047100 | 6.62e-03 | 2.88e-01 |
| METABOLISM OF AMINO ACIDS AND DERIVATIVES | 315 | 5.66e-25 | 1.11e-22 | 0.3870 | 0.177000 | 0.344000 | 6.72e-08 | 9.21e-26 |
| GOLGI TO ER RETROGRADE TRANSPORT | 119 | 4.53e-03 | 2.99e-02 | 0.1550 | 0.155000 | -0.010600 | 3.57e-03 | 8.41e-01 |
| SUMOYLATION OF UBIQUITINYLATION PROTEINS | 37 | 2.94e-03 | 2.09e-02 | 0.3600 | -0.158000 | -0.323000 | 9.65e-02 | 6.71e-04 |
| COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING | 26 | 2.57e-03 | 1.95e-02 | 0.4440 | 0.385000 | 0.222000 | 6.88e-04 | 4.96e-02 |
| SUMOYLATION OF RNA BINDING PROTEINS | 45 | 6.22e-05 | 9.88e-04 | 0.4300 | -0.214000 | -0.373000 | 1.32e-02 | 1.49e-05 |
| CELLULAR RESPONSE TO CHEMICAL STRESS | 151 | 8.88e-09 | 4.54e-07 | 0.3150 | 0.131000 | 0.287000 | 5.67e-03 | 1.19e-09 |
| TRANSLATION | 286 | 3.50e-34 | 4.11e-31 | 0.4890 | 0.260000 | 0.414000 | 3.84e-14 | 1.65e-33 |
| REGULATION OF RUNX2 EXPRESSION AND ACTIVITY | 69 | 6.01e-04 | 6.30e-03 | 0.2920 | 0.115000 | 0.268000 | 9.98e-02 | 1.18e-04 |
| METABOLISM OF CARBOHYDRATES | 258 | 2.64e-05 | 4.70e-04 | 0.1510 | 0.151000 | -0.001210 | 2.92e-05 | 9.73e-01 |
| HEME SIGNALING | 45 | 3.28e-03 | 2.32e-02 | 0.3220 | -0.290000 | -0.140000 | 7.50e-04 | 1.04e-01 |
| CELLULAR RESPONSE TO HYPOXIA | 72 | 8.55e-07 | 3.09e-05 | 0.4110 | 0.210000 | 0.353000 | 2.12e-03 | 2.23e-07 |
| C TYPE LECTIN RECEPTORS CLRS | 111 | 1.25e-03 | 1.11e-02 | 0.2090 | 0.061700 | 0.200000 | 2.62e-01 | 2.78e-04 |
| RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA | 24 | 1.11e-03 | 9.99e-03 | 0.5040 | -0.283000 | -0.417000 | 1.64e-02 | 4.05e-04 |
| NS1 MEDIATED EFFECTS ON HOST PATHWAYS | 37 | 5.47e-04 | 5.79e-03 | 0.4230 | -0.225000 | -0.358000 | 1.79e-02 | 1.66e-04 |
| HEDGEHOG OFF STATE | 106 | 7.65e-06 | 1.67e-04 | 0.3050 | 0.271000 | 0.139000 | 1.42e-06 | 1.34e-02 |
| NETRIN 1 SIGNALING | 49 | 5.32e-03 | 3.38e-02 | 0.2980 | -0.134000 | -0.266000 | 1.05e-01 | 1.29e-03 |
| AUTOPHAGY | 139 | 1.78e-03 | 1.44e-02 | 0.1770 | 0.172000 | 0.041600 | 4.62e-04 | 3.98e-01 |
| KERATAN SULFATE KERATIN METABOLISM | 30 | 8.13e-03 | 4.78e-02 | 0.3730 | 0.320000 | 0.192000 | 2.40e-03 | 6.86e-02 |
| MAPK6 MAPK4 SIGNALING | 83 | 9.60e-04 | 9.02e-03 | 0.2600 | 0.109000 | 0.236000 | 8.65e-02 | 1.98e-04 |
| THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT | 66 | 8.88e-08 | 4.01e-06 | 0.4700 | 0.389000 | 0.264000 | 4.67e-08 | 2.14e-04 |
| TRANSCRIPTIONAL REGULATION BY RUNX3 | 92 | 1.68e-04 | 2.19e-03 | 0.2800 | 0.126000 | 0.250000 | 3.73e-02 | 3.37e-05 |
| BETA CATENIN INDEPENDENT WNT SIGNALING | 138 | 2.41e-04 | 2.92e-03 | 0.2160 | 0.078500 | 0.201000 | 1.12e-01 | 4.48e-05 |
| CYTOPROTECTION BY HMOX1 | 119 | 4.74e-06 | 1.18e-04 | 0.2950 | 0.138000 | 0.261000 | 9.29e-03 | 9.23e-07 |
| TRANSCRIPTIONAL REGULATION BY RUNX2 | 108 | 3.85e-03 | 2.61e-02 | 0.1960 | 0.063100 | 0.185000 | 2.58e-01 | 8.83e-04 |
| SIGNALING BY NTRKS | 130 | 3.72e-03 | 2.59e-02 | 0.1750 | -0.048200 | -0.169000 | 3.43e-01 | 9.15e-04 |
| MITOTIC PROMETAPHASE | 177 | 4.09e-03 | 2.73e-02 | 0.1400 | -0.018800 | -0.139000 | 6.66e-01 | 1.48e-03 |
| TCR SIGNALING | 100 | 2.13e-03 | 1.65e-02 | 0.2200 | 0.084600 | 0.203000 | 1.44e-01 | 4.52e-04 |
| CYTOKINE SIGNALING IN IMMUNE SYSTEM | 539 | 1.11e-04 | 1.55e-03 | 0.0837 | -0.068200 | 0.048500 | 6.94e-03 | 5.50e-02 |
| RRNA PROCESSING | 194 | 2.22e-14 | 1.86e-12 | 0.3800 | 0.205000 | 0.320000 | 9.25e-07 | 1.52e-14 |
| SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS | 58 | 2.33e-04 | 2.85e-03 | 0.3560 | -0.187000 | -0.303000 | 1.36e-02 | 6.77e-05 |
| ORC1 REMOVAL FROM CHROMATIN | 67 | 2.61e-03 | 1.95e-02 | 0.2740 | 0.129000 | 0.241000 | 6.88e-02 | 6.34e-04 |
| NEUTROPHIL DEGRANULATION | 385 | 2.71e-08 | 1.28e-06 | 0.1870 | 0.063600 | 0.175000 | 3.25e-02 | 3.72e-09 |
| DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 79 | 7.56e-04 | 7.66e-03 | 0.2780 | 0.133000 | 0.244000 | 4.17e-02 | 1.77e-04 |
| RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS | 83 | 2.83e-05 | 4.96e-04 | 0.3330 | 0.174000 | 0.284000 | 6.14e-03 | 8.06e-06 |
| ASPARAGINE N LINKED GLYCOSYLATION | 285 | 2.64e-03 | 1.95e-02 | 0.1080 | 0.108000 | -0.000284 | 1.67e-03 | 9.93e-01 |
| CLEC7A DECTIN 1 SIGNALING | 95 | 8.38e-04 | 8.09e-03 | 0.2500 | 0.116000 | 0.222000 | 5.07e-02 | 1.88e-04 |
| SIGNALING BY HEDGEHOG | 141 | 4.57e-05 | 7.47e-04 | 0.2440 | 0.217000 | 0.111000 | 8.97e-06 | 2.27e-02 |
| SIGNALING BY VEGF | 103 | 7.15e-03 | 4.29e-02 | 0.1940 | -0.179000 | -0.075200 | 1.67e-03 | 1.88e-01 |
| INNATE IMMUNE SYSTEM | 778 | 1.36e-07 | 5.87e-06 | 0.1130 | 0.011200 | 0.113000 | 5.97e-01 | 9.90e-08 |
| ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 64 | 2.73e-03 | 2.00e-02 | 0.2830 | 0.145000 | 0.243000 | 4.48e-02 | 7.66e-04 |
| S PHASE | 153 | 6.10e-03 | 3.79e-02 | 0.1580 | 0.051600 | 0.149000 | 2.71e-01 | 1.44e-03 |
| METABOLISM OF POLYAMINES | 57 | 6.51e-06 | 1.47e-04 | 0.4370 | 0.257000 | 0.353000 | 7.87e-04 | 4.02e-06 |
| MITOTIC G1 PHASE AND G1 S TRANSITION | 140 | 4.71e-03 | 3.08e-02 | 0.1730 | 0.064900 | 0.160000 | 1.85e-01 | 1.06e-03 |
| RAC1 GTPASE CYCLE | 177 | 3.83e-03 | 2.61e-02 | 0.1540 | -0.145000 | -0.050300 | 8.72e-04 | 2.49e-01 |
| CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 46 | 8.34e-07 | 3.09e-05 | 0.5290 | 0.324000 | 0.418000 | 1.45e-04 | 9.15e-07 |
| FCERI MEDIATED NF KB ACTIVATION | 77 | 1.05e-04 | 1.49e-03 | 0.3260 | 0.179000 | 0.272000 | 6.56e-03 | 3.69e-05 |
| SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE | 86 | 3.83e-03 | 2.61e-02 | 0.2360 | 0.117000 | 0.205000 | 5.99e-02 | 1.03e-03 |
| CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY | 84 | 2.99e-05 | 5.17e-04 | 0.3350 | 0.190000 | 0.275000 | 2.57e-03 | 1.32e-05 |
| DNA REPLICATION PRE INITIATION | 79 | 2.22e-03 | 1.69e-02 | 0.2610 | 0.137000 | 0.222000 | 3.51e-02 | 6.60e-04 |
| DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS | 59 | 3.19e-06 | 8.51e-05 | 0.4440 | 0.269000 | 0.353000 | 3.57e-04 | 2.72e-06 |
| VESICLE MEDIATED TRANSPORT | 611 | 6.45e-03 | 3.95e-02 | 0.0594 | 0.029300 | -0.051600 | 2.18e-01 | 2.99e-02 |
| PROTEIN LOCALIZATION | 156 | 1.89e-06 | 5.54e-05 | 0.2750 | 0.151000 | 0.230000 | 1.18e-03 | 7.22e-07 |
| G PROTEIN MEDIATED EVENTS | 52 | 4.88e-03 | 3.15e-02 | 0.3030 | -0.250000 | -0.172000 | 1.81e-03 | 3.22e-02 |
| PHASE 0 RAPID DEPOLARISATION | 30 | 3.54e-04 | 4.00e-03 | 0.4950 | -0.309000 | -0.387000 | 3.45e-03 | 2.48e-04 |
| SCF SKP2 MEDIATED DEGRADATION OF P27 P21 | 59 | 2.20e-05 | 4.03e-04 | 0.4090 | 0.248000 | 0.325000 | 1.00e-03 | 1.59e-05 |
| REGULATION OF RAS BY GAPS | 66 | 1.03e-04 | 1.49e-03 | 0.3560 | 0.210000 | 0.288000 | 3.12e-03 | 5.38e-05 |
| ABC FAMILY PROTEINS MEDIATED TRANSPORT | 94 | 2.03e-03 | 1.62e-02 | 0.2410 | 0.128000 | 0.204000 | 3.19e-02 | 6.18e-04 |
| INFECTIOUS DISEASE | 732 | 1.41e-07 | 5.87e-06 | 0.1310 | 0.047200 | 0.122000 | 3.04e-02 | 1.96e-08 |
| ABC TRANSPORTER DISORDERS | 70 | 1.02e-04 | 1.49e-03 | 0.3460 | 0.206000 | 0.279000 | 2.91e-03 | 5.56e-05 |
| SIGNALING BY NOTCH4 | 83 | 9.86e-04 | 9.13e-03 | 0.2740 | 0.154000 | 0.226000 | 1.54e-02 | 3.63e-04 |
| METABOLISM OF LIPIDS | 613 | 2.88e-03 | 2.09e-02 | 0.0779 | 0.009040 | 0.077400 | 7.03e-01 | 1.12e-03 |
| INTERLEUKIN 1 FAMILY SIGNALING | 121 | 2.14e-03 | 1.65e-02 | 0.2120 | 0.113000 | 0.180000 | 3.23e-02 | 6.53e-04 |
| CELLULAR RESPONSES TO EXTERNAL STIMULI | 603 | 1.41e-09 | 7.51e-08 | 0.1740 | 0.087500 | 0.150000 | 2.55e-04 | 3.64e-10 |
| DISEASES OF METABOLISM | 197 | 8.62e-06 | 1.81e-04 | 0.2320 | 0.191000 | 0.132000 | 4.06e-06 | 1.39e-03 |
| REGULATION OF HMOX1 EXPRESSION AND ACTIVITY | 63 | 1.59e-05 | 3.01e-04 | 0.4030 | 0.255000 | 0.313000 | 4.70e-04 | 1.77e-05 |
| NEGATIVE REGULATION OF NOTCH4 SIGNALING | 54 | 6.68e-06 | 1.48e-04 | 0.4530 | 0.290000 | 0.348000 | 2.23e-04 | 9.87e-06 |
| RNA POLYMERASE II TRANSCRIPTION | 1087 | 5.43e-05 | 8.73e-04 | 0.0827 | -0.079500 | -0.022700 | 1.12e-05 | 2.11e-01 |
| DEGRADATION OF DVL | 55 | 1.26e-05 | 2.51e-04 | 0.4370 | 0.279000 | 0.336000 | 3.41e-04 | 1.66e-05 |
| GLYCOSAMINOGLYCAN METABOLISM | 114 | 8.43e-03 | 4.90e-02 | 0.1940 | 0.162000 | 0.107000 | 2.90e-03 | 4.91e-02 |
| STABILIZATION OF P53 | 54 | 1.48e-06 | 4.58e-05 | 0.4810 | 0.312000 | 0.366000 | 7.15e-05 | 3.23e-06 |
| G1 S DNA DAMAGE CHECKPOINTS | 65 | 4.50e-05 | 7.44e-04 | 0.3780 | 0.239000 | 0.293000 | 8.56e-04 | 4.46e-05 |
| INTERLEUKIN 1 SIGNALING | 96 | 3.32e-04 | 3.82e-03 | 0.2770 | 0.168000 | 0.221000 | 4.51e-03 | 1.90e-04 |
| MITOCHONDRIAL TRANSLATION | 93 | 1.35e-10 | 7.54e-09 | 0.4780 | 0.313000 | 0.362000 | 1.90e-07 | 1.65e-09 |
| NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION | 179 | 4.40e-04 | 4.88e-03 | 0.1980 | -0.114000 | -0.162000 | 8.73e-03 | 1.82e-04 |
| DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING | 59 | 1.77e-06 | 5.33e-05 | 0.4580 | 0.299000 | 0.347000 | 7.06e-05 | 4.13e-06 |
| APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS | 81 | 6.18e-06 | 1.42e-04 | 0.3710 | 0.238000 | 0.285000 | 2.11e-04 | 9.27e-06 |
| TRANSMISSION ACROSS CHEMICAL SYNAPSES | 240 | 2.23e-05 | 4.03e-04 | 0.2020 | -0.118000 | -0.164000 | 1.64e-03 | 1.19e-05 |
| HEDGEHOG ON STATE | 82 | 1.70e-04 | 2.20e-03 | 0.3140 | 0.198000 | 0.243000 | 1.95e-03 | 1.42e-04 |
| DNA REPLICATION | 121 | 4.30e-03 | 2.86e-02 | 0.2030 | 0.119000 | 0.164000 | 2.36e-02 | 1.83e-03 |
| REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 1.01e-03 | 9.29e-03 | 0.2760 | 0.172000 | 0.216000 | 6.45e-03 | 6.39e-04 |
| NEURONAL SYSTEM | 368 | 2.12e-11 | 1.32e-09 | 0.2500 | -0.155000 | -0.197000 | 3.75e-07 | 9.22e-11 |
| DEGRADATION OF GLI1 BY THE PROTEASOME | 57 | 3.40e-05 | 5.79e-04 | 0.4110 | 0.269000 | 0.311000 | 4.54e-04 | 4.99e-05 |
| DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX | 82 | 2.06e-03 | 1.62e-02 | 0.2640 | 0.165000 | 0.207000 | 9.77e-03 | 1.23e-03 |
| REGULATION OF PTEN STABILITY AND ACTIVITY | 66 | 1.01e-04 | 1.49e-03 | 0.3610 | 0.234000 | 0.275000 | 1.02e-03 | 1.15e-04 |
| AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA | 53 | 1.34e-06 | 4.34e-05 | 0.4890 | 0.325000 | 0.365000 | 4.22e-05 | 4.33e-06 |
| DEGRADATION OF AXIN | 53 | 8.04e-06 | 1.72e-04 | 0.4550 | 0.302000 | 0.341000 | 1.46e-04 | 1.78e-05 |
| VOLTAGE GATED POTASSIUM CHANNELS | 39 | 5.74e-06 | 1.38e-04 | 0.5380 | -0.399000 | -0.361000 | 1.59e-05 | 9.64e-05 |
| UCH PROTEINASES | 89 | 5.01e-04 | 5.35e-03 | 0.2820 | 0.180000 | 0.217000 | 3.42e-03 | 3.95e-04 |
| HEDGEHOG LIGAND BIOGENESIS | 61 | 8.67e-07 | 3.09e-05 | 0.4630 | 0.309000 | 0.345000 | 2.98e-05 | 3.22e-06 |
| DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM | 40 | 1.35e-03 | 1.16e-02 | 0.3930 | 0.260000 | 0.295000 | 4.50e-03 | 1.24e-03 |
| APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 70 | 1.01e-05 | 2.05e-04 | 0.3930 | 0.263000 | 0.292000 | 1.45e-04 | 2.46e-05 |
| MUSCLE CONTRACTION | 162 | 1.66e-03 | 1.38e-02 | 0.1920 | -0.149000 | -0.121000 | 1.05e-03 | 8.12e-03 |
| SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS | 73 | 1.89e-04 | 2.39e-03 | 0.3320 | -0.220000 | -0.248000 | 1.16e-03 | 2.45e-04 |
| ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 73 | 3.65e-03 | 2.55e-02 | 0.2680 | -0.203000 | -0.176000 | 2.75e-03 | 9.51e-03 |
| PI METABOLISM | 79 | 6.22e-03 | 3.83e-02 | 0.2450 | -0.160000 | -0.186000 | 1.39e-02 | 4.33e-03 |
| PROTEIN FOLDING | 89 | 6.03e-03 | 3.77e-02 | 0.2320 | 0.174000 | 0.154000 | 4.61e-03 | 1.22e-02 |
| PCP CE PATHWAY | 89 | 2.07e-06 | 5.80e-05 | 0.3720 | 0.272000 | 0.253000 | 9.00e-06 | 3.65e-05 |
| MITOCHONDRIAL PROTEIN IMPORT | 63 | 6.57e-05 | 1.02e-03 | 0.3790 | 0.258000 | 0.277000 | 3.92e-04 | 1.42e-04 |
| TNFR2 NON CANONICAL NF KB PATHWAY | 79 | 1.12e-04 | 1.55e-03 | 0.3290 | 0.224000 | 0.241000 | 5.79e-04 | 2.14e-04 |
| METABOLISM OF RNA | 644 | 2.64e-08 | 1.28e-06 | 0.1620 | 0.109000 | 0.120000 | 2.41e-06 | 2.36e-07 |
| POTASSIUM CHANNELS | 90 | 3.71e-06 | 9.70e-05 | 0.3620 | -0.251000 | -0.261000 | 3.94e-05 | 1.92e-05 |
| REGULATION OF RUNX3 EXPRESSION AND ACTIVITY | 53 | 6.09e-06 | 1.42e-04 | 0.4620 | 0.322000 | 0.331000 | 5.11e-05 | 3.07e-05 |
| CARDIAC CONDUCTION | 109 | 1.93e-05 | 3.61e-04 | 0.3060 | -0.220000 | -0.213000 | 7.14e-05 | 1.22e-04 |
| DAG AND IP3 SIGNALING | 40 | 6.91e-03 | 4.16e-02 | 0.3420 | -0.245000 | -0.239000 | 7.41e-03 | 8.98e-03 |
| ASYMMETRIC LOCALIZATION OF PCP PROTEINS | 62 | 2.03e-06 | 5.80e-05 | 0.4460 | 0.314000 | 0.317000 | 1.96e-05 | 1.57e-05 |
Detailed Gene set reports
ENDOSOMAL VACUOLAR PATHWAY
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POST CHAPERONIN TUBULIN FOLDING PATHWAY
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NUCLEOTIDE LIKE PURINERGIC RECEPTORS
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REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM
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CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
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CYTOSOLIC TRNA AMINOACYLATION
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YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
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TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
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EUKARYOTIC TRANSLATION ELONGATION
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G BETA GAMMA SIGNALLING THROUGH CDC42
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RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
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EUKARYOTIC TRANSLATION INITIATION
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ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
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SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
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WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
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FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
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ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
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IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL
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SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
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GLYCOLYSIS
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AGGREPHAGY
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FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
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RHO GTPASES ACTIVATE WASPS AND WAVES
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GLUCOSE METABOLISM
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REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
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INTERFERON ALPHA BETA SIGNALING
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G PROTEIN ACTIVATION
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THROMBOXANE SIGNALLING THROUGH TP RECEPTOR
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SEROTONIN NEUROTRANSMITTER RELEASE CYCLE
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HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
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GAP JUNCTION ASSEMBLY
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CGMP EFFECTS
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SELENOAMINO ACID METABOLISM
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COLLAGEN CHAIN TRIMERIZATION
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ARACHIDONIC ACID METABOLISM
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GLUTATHIONE CONJUGATION
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COMPLEX I BIOGENESIS
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NONSENSE MEDIATED DECAY NMD
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CA2 PATHWAY
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BRANCHED CHAIN AMINO ACID CATABOLISM
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NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
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SIGNAL AMPLIFICATION
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INTERFERON GAMMA SIGNALING
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RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
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RESPIRATORY ELECTRON TRANSPORT
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DETOXIFICATION OF REACTIVE OXYGEN SPECIES
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NCAM1 INTERACTIONS
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TRNA AMINOACYLATION
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COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
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FOXO MEDIATED TRANSCRIPTION
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Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.3.3 (2024-02-29)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.10.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## time zone: Australia/Melbourne
## tzcode source: system (glibc)
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] GGally_2.2.1 gtools_3.9.5
## [3] echarts4r_0.4.5 beeswarm_0.4.0
## [5] pkgload_1.3.4 vioplot_0.4.0
## [7] sm_2.2-6.0 kableExtra_1.4.0
## [9] topconfects_1.18.0 limma_3.58.1
## [11] eulerr_7.0.0 mitch_1.15.0
## [13] MASS_7.3-60.0.1 fgsea_1.28.0
## [15] gplots_3.1.3.1 DESeq2_1.42.0
## [17] SummarizedExperiment_1.32.0 Biobase_2.62.0
## [19] MatrixGenerics_1.14.0 matrixStats_1.2.0
## [21] GenomicRanges_1.54.1 GenomeInfoDb_1.38.6
## [23] IRanges_2.36.0 S4Vectors_0.40.2
## [25] BiocGenerics_0.48.1 reshape2_1.4.4
## [27] lubridate_1.9.3 forcats_1.0.0
## [29] stringr_1.5.1 dplyr_1.1.4
## [31] purrr_1.0.2 readr_2.1.5
## [33] tidyr_1.3.1 tibble_3.2.1
## [35] ggplot2_3.5.0 tidyverse_2.0.0
## [37] zoo_1.8-12
##
## loaded via a namespace (and not attached):
## [1] bitops_1.0-7 gridExtra_2.3 rlang_1.1.3
## [4] magrittr_2.0.3 compiler_4.3.3 polylabelr_0.2.0
## [7] systemfonts_1.0.5 vctrs_0.6.5 pkgconfig_2.0.3
## [10] crayon_1.5.2 fastmap_1.1.1 XVector_0.42.0
## [13] ellipsis_0.3.2 labeling_0.4.3 caTools_1.18.2
## [16] utf8_1.2.4 promises_1.2.1 rmarkdown_2.25
## [19] tzdb_0.4.0 xfun_0.42 zlibbioc_1.48.0
## [22] cachem_1.0.8 jsonlite_1.8.8 highr_0.10
## [25] later_1.3.2 DelayedArray_0.28.0 BiocParallel_1.36.0
## [28] parallel_4.3.3 R6_2.5.1 bslib_0.6.1
## [31] stringi_1.8.3 RColorBrewer_1.1-3 jquerylib_0.1.4
## [34] assertthat_0.2.1 Rcpp_1.0.12 knitr_1.45
## [37] httpuv_1.6.14 Matrix_1.6-5 timechange_0.3.0
## [40] tidyselect_1.2.0 rstudioapi_0.15.0 abind_1.4-5
## [43] yaml_2.3.8 codetools_0.2-19 lattice_0.22-5
## [46] plyr_1.8.9 shiny_1.8.0 withr_3.0.0
## [49] evaluate_0.23 polyclip_1.10-6 ggstats_0.5.1
## [52] xml2_1.3.6 pillar_1.9.0 KernSmooth_2.23-22
## [55] generics_0.1.3 RCurl_1.98-1.14 hms_1.1.3
## [58] munsell_0.5.0 scales_1.3.0 xtable_1.8-4
## [61] glue_1.7.0 tools_4.3.3 data.table_1.15.2
## [64] locfit_1.5-9.8 fastmatch_1.1-4 cowplot_1.1.3
## [67] grid_4.3.3 colorspace_2.1-0 GenomeInfoDbData_1.2.11
## [70] cli_3.6.2 fansi_1.0.6 S4Arrays_1.2.0
## [73] viridisLite_0.4.2 svglite_2.1.3 gtable_0.3.4
## [76] sass_0.4.8 digest_0.6.34 SparseArray_1.2.4
## [79] farver_2.1.1 htmlwidgets_1.6.4 htmltools_0.5.7
## [82] lifecycle_1.0.4 statmod_1.5.0 mime_0.12END of report