date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik 0.2684894
0610009E02Rik -0.7521235
0610009L18Rik -1.1838923
0610010K14Rik -0.0433030
0610012G03Rik -0.1930476
0610030E20Rik 1.0496464

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16805
duplicated_genes_present 0
num_profile_genes_in_sets 8283
num_profile_genes_not_in_sets 8522

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 437
num_genesets_included 1167

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
MET ACTIVATES RAP1 AND RAC1 11 1.04e-03 -0.571 2.96e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.15e-03 -0.534 5.11e-02
ACTIVATION OF RAC1 13 1.76e-03 -0.501 4.48e-02
INITIAL TRIGGERING OF COMPLEMENT 10 1.00e-02 0.470 1.54e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 6.33e-03 0.437 1.15e-01
EUKARYOTIC TRANSLATION ELONGATION 87 1.86e-12 0.437 2.18e-09
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.22e-02 -0.437 1.71e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 6.81e-03 0.433 1.22e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 2.78e-03 0.432 6.36e-02
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 9.09e-04 0.428 2.65e-02
SCAVENGING BY CLASS A RECEPTORS 14 7.55e-03 0.412 1.31e-01
SEROTONIN RECEPTORS 10 2.92e-02 -0.398 2.96e-01
COLLAGEN CHAIN TRIMERIZATION 40 1.46e-05 0.396 8.12e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 6.15e-03 -0.396 1.14e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.89e-02 0.376 2.27e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 3.75e-10 0.374 7.95e-08
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.77e-02 0.367 2.92e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 9.65e-07 0.357 7.04e-05
NONSENSE MEDIATED DECAY NMD 109 4.09e-10 0.347 7.95e-08
AGGREPHAGY 35 5.20e-04 0.339 1.64e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 6.37e-02 -0.339 4.49e-01
COMPLEMENT CASCADE 22 6.03e-03 0.338 1.14e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 6.03e-03 0.338 1.14e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 1.32e-02 -0.337 1.80e-01
CROSSLINKING OF COLLAGEN FIBRILS 14 2.90e-02 0.337 2.96e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 4.68e-03 0.334 9.76e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 8.55e-03 -0.332 1.39e-01
SELENOAMINO ACID METABOLISM 108 2.69e-09 0.331 4.36e-07
P75NTR SIGNALS VIA NF KB 16 2.50e-02 0.324 2.73e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.25e-02 -0.320 2.57e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 8.06e-02 -0.319 4.80e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 8.18e-05 0.319 3.54e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.55e-08 0.318 1.81e-06
FERTILIZATION 12 5.67e-02 0.318 4.34e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.36e-02 0.317 2.62e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 4.78e-02 0.317 3.87e-01
CD28 DEPENDENT VAV1 PATHWAY 11 6.87e-02 -0.317 4.49e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.08e-02 -0.315 4.49e-01
INSULIN PROCESSING 24 7.89e-03 -0.313 1.32e-01
RHO GTPASES ACTIVATE ROCKS 19 1.84e-02 0.313 2.27e-01
PEXOPHAGY 11 7.55e-02 0.310 4.68e-01
TIGHT JUNCTION INTERACTIONS 18 2.31e-02 -0.309 2.60e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 2.05e-02 -0.307 2.36e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 5.53e-02 0.307 4.27e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.88e-05 0.307 9.98e-04
REDUCTION OF CYTOSOLIC CA LEVELS 11 8.04e-02 -0.304 4.80e-01
COLLAGEN DEGRADATION 51 1.87e-04 0.303 7.26e-03
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 7.02e-02 -0.302 4.49e-01
CGMP EFFECTS 15 4.32e-02 -0.301 3.71e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 6.02e-02 0.301 4.47e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
MET ACTIVATES RAP1 AND RAC1 11 1.04e-03 -5.71e-01 2.96e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.15e-03 -5.34e-01 5.11e-02
ACTIVATION OF RAC1 13 1.76e-03 -5.01e-01 4.48e-02
INITIAL TRIGGERING OF COMPLEMENT 10 1.00e-02 4.70e-01 1.54e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 6.33e-03 4.37e-01 1.15e-01
EUKARYOTIC TRANSLATION ELONGATION 87 1.86e-12 4.37e-01 2.18e-09
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.22e-02 -4.37e-01 1.71e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 6.81e-03 4.33e-01 1.22e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 2.78e-03 4.32e-01 6.36e-02
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 9.09e-04 4.28e-01 2.65e-02
SCAVENGING BY CLASS A RECEPTORS 14 7.55e-03 4.12e-01 1.31e-01
SEROTONIN RECEPTORS 10 2.92e-02 -3.98e-01 2.96e-01
COLLAGEN CHAIN TRIMERIZATION 40 1.46e-05 3.96e-01 8.12e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 6.15e-03 -3.96e-01 1.14e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.89e-02 3.76e-01 2.27e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 3.75e-10 3.74e-01 7.95e-08
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.77e-02 3.67e-01 2.92e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 9.65e-07 3.57e-01 7.04e-05
NONSENSE MEDIATED DECAY NMD 109 4.09e-10 3.47e-01 7.95e-08
AGGREPHAGY 35 5.20e-04 3.39e-01 1.64e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 6.37e-02 -3.39e-01 4.49e-01
COMPLEMENT CASCADE 22 6.03e-03 3.38e-01 1.14e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 6.03e-03 3.38e-01 1.14e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 1.32e-02 -3.37e-01 1.80e-01
CROSSLINKING OF COLLAGEN FIBRILS 14 2.90e-02 3.37e-01 2.96e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 4.68e-03 3.34e-01 9.76e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 8.55e-03 -3.32e-01 1.39e-01
SELENOAMINO ACID METABOLISM 108 2.69e-09 3.31e-01 4.36e-07
P75NTR SIGNALS VIA NF KB 16 2.50e-02 3.24e-01 2.73e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.25e-02 -3.20e-01 2.57e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 8.06e-02 -3.19e-01 4.80e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 8.18e-05 3.19e-01 3.54e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.55e-08 3.18e-01 1.81e-06
FERTILIZATION 12 5.67e-02 3.18e-01 4.34e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 2.36e-02 3.17e-01 2.62e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 4.78e-02 3.17e-01 3.87e-01
CD28 DEPENDENT VAV1 PATHWAY 11 6.87e-02 -3.17e-01 4.49e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.08e-02 -3.15e-01 4.49e-01
INSULIN PROCESSING 24 7.89e-03 -3.13e-01 1.32e-01
RHO GTPASES ACTIVATE ROCKS 19 1.84e-02 3.13e-01 2.27e-01
PEXOPHAGY 11 7.55e-02 3.10e-01 4.68e-01
TIGHT JUNCTION INTERACTIONS 18 2.31e-02 -3.09e-01 2.60e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 2.05e-02 -3.07e-01 2.36e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 5.53e-02 3.07e-01 4.27e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.88e-05 3.07e-01 9.98e-04
REDUCTION OF CYTOSOLIC CA LEVELS 11 8.04e-02 -3.04e-01 4.80e-01
COLLAGEN DEGRADATION 51 1.87e-04 3.03e-01 7.26e-03
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 7.02e-02 -3.02e-01 4.49e-01
CGMP EFFECTS 15 4.32e-02 -3.01e-01 3.71e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 6.02e-02 3.01e-01 4.47e-01
COLLAGEN FORMATION 79 3.88e-06 3.01e-01 2.66e-04
ACTIVATION OF SMO 16 3.76e-02 3.00e-01 3.48e-01
EUKARYOTIC TRANSLATION INITIATION 114 3.30e-08 3.00e-01 3.20e-06
JOSEPHIN DOMAIN DUBS 11 8.80e-02 2.97e-01 4.84e-01
CYTOSOLIC TRNA AMINOACYLATION 24 1.18e-02 2.97e-01 1.71e-01
PROCESSING AND ACTIVATION OF SUMO 10 1.05e-01 -2.96e-01 5.28e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 11 9.01e-02 2.95e-01 4.86e-01
REGULATION OF IFNG SIGNALING 13 6.66e-02 -2.94e-01 4.49e-01
INTERFERON ALPHA BETA SIGNALING 52 2.54e-04 -2.93e-01 9.25e-03
ECM PROTEOGLYCANS 65 4.38e-05 2.93e-01 2.04e-03
GLUTAMATE AND GLUTAMINE METABOLISM 13 6.74e-02 2.93e-01 4.49e-01
PYRIMIDINE SALVAGE 10 1.12e-01 -2.90e-01 5.39e-01
COMPLEX I BIOGENESIS 56 1.82e-04 2.89e-01 7.26e-03
MET ACTIVATES PTK2 SIGNALING 29 7.19e-03 2.88e-01 1.27e-01
SMOOTH MUSCLE CONTRACTION 33 4.28e-03 2.87e-01 9.24e-02
INTERLEUKIN 37 SIGNALING 19 3.17e-02 2.85e-01 3.05e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 5.89e-02 -2.82e-01 4.40e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 6.86e-02 2.81e-01 4.49e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 5.94e-03 2.81e-01 1.14e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 6.91e-02 -2.81e-01 4.49e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 8.12e-02 2.79e-01 4.81e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 9.80e-02 2.76e-01 5.06e-01
MRNA SPLICING 188 8.46e-11 2.75e-01 2.47e-08
ELASTIC FIBRE FORMATION 37 3.89e-03 2.74e-01 8.59e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.35e-01 -2.73e-01 5.60e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 1.02e-01 2.72e-01 5.22e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.56e-02 -2.71e-01 3.32e-01
PYRIMIDINE CATABOLISM 10 1.37e-01 -2.71e-01 5.60e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 1.05e-01 -2.70e-01 5.28e-01
CS DS DEGRADATION 14 8.37e-02 2.67e-01 4.84e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 4.46e-04 2.64e-01 1.45e-02
CELL CELL JUNCTION ORGANIZATION 50 1.31e-03 -2.63e-01 3.56e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 1.22e-08 2.61e-01 1.59e-06
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 1.19e-01 -2.60e-01 5.54e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.15e-02 2.59e-01 3.05e-01
PROLONGED ERK ACTIVATION EVENTS 14 9.57e-02 -2.57e-01 4.99e-01
HSF1 DEPENDENT TRANSACTIVATION 34 9.65e-03 2.57e-01 1.50e-01
P75NTR REGULATES AXONOGENESIS 10 1.60e-01 -2.56e-01 6.02e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.25e-01 -2.56e-01 5.56e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.48e-01 -2.52e-01 5.78e-01
DISEASES OF DNA REPAIR 11 1.53e-01 2.49e-01 5.87e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 1.56e-01 2.47e-01 5.91e-01
RHO GTPASES ACTIVATE CIT 18 7.04e-02 2.46e-01 4.49e-01
SYNDECAN INTERACTIONS 26 3.06e-02 2.45e-01 3.05e-01
RMTS METHYLATE HISTONE ARGININES 42 6.13e-03 2.44e-01 1.14e-01
RAP1 SIGNALLING 15 1.01e-01 -2.44e-01 5.18e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.82e-01 -2.44e-01 6.38e-01
BIOTIN TRANSPORT AND METABOLISM 11 1.64e-01 2.42e-01 6.08e-01
CELLULAR RESPONSE TO STARVATION 145 5.19e-07 2.42e-01 4.33e-05
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 1.86e-01 -2.42e-01 6.43e-01
CHAPERONE MEDIATED AUTOPHAGY 20 6.19e-02 2.41e-01 4.49e-01
AMINE LIGAND BINDING RECEPTORS 31 2.04e-02 -2.41e-01 2.36e-01
ATTENUATION PHASE 24 4.16e-02 2.40e-01 3.60e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 5.42e-02 2.37e-01 4.24e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 6.66e-02 -2.37e-01 4.49e-01
RAB GERANYLGERANYLATION 57 2.00e-03 -2.37e-01 4.96e-02
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 1.75e-01 2.36e-01 6.24e-01
SIGNALING BY KIT IN DISEASE 20 6.81e-02 -2.36e-01 4.49e-01
POLO LIKE KINASE MEDIATED EVENTS 13 1.44e-01 2.34e-01 5.71e-01
REPRESSION OF WNT TARGET GENES 14 1.30e-01 2.34e-01 5.60e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 8.66e-02 -2.33e-01 4.84e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 1.88e-02 -2.33e-01 2.27e-01
RRNA PROCESSING 194 3.06e-08 2.31e-01 3.20e-06
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.16e-02 -2.31e-01 1.71e-01
DISEASES OF MITOTIC CELL CYCLE 37 1.53e-02 -2.31e-01 1.98e-01
REGULATION OF KIT SIGNALING 16 1.14e-01 -2.28e-01 5.39e-01
CD28 CO STIMULATION 30 3.09e-02 -2.28e-01 3.05e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 18 9.45e-02 -2.28e-01 4.97e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 8.60e-02 -2.28e-01 4.84e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.13e-01 2.27e-01 6.59e-01
DNA DAMAGE BYPASS 46 7.61e-03 -2.27e-01 1.31e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 3.41e-02 -2.27e-01 3.24e-01
GAP JUNCTION ASSEMBLY 21 7.25e-02 2.26e-01 4.57e-01
TRANSLATION 286 5.63e-11 2.26e-01 2.19e-08
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.33e-01 -2.24e-01 5.60e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 2.99e-09 2.24e-01 4.36e-07
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 3.11e-02 -2.24e-01 3.05e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 7.62e-02 -2.24e-01 4.70e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.15e-02 2.23e-01 3.60e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 1.37e-01 -2.22e-01 5.60e-01
INTERFERON GAMMA SIGNALING 73 1.07e-03 -2.22e-01 2.96e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.89e-02 -2.22e-01 3.54e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 7.24e-04 2.20e-01 2.22e-02
SIGNALING BY HIPPO 20 8.88e-02 -2.20e-01 4.84e-01
UNWINDING OF DNA 12 1.89e-01 -2.19e-01 6.43e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 8.28e-03 2.18e-01 1.36e-01
ANCHORING FIBRIL FORMATION 13 1.77e-01 2.16e-01 6.28e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 2.15e-01 2.16e-01 6.63e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 5.73e-02 -2.15e-01 4.34e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 1.24e-01 -2.15e-01 5.56e-01
ADHERENS JUNCTIONS INTERACTIONS 30 4.15e-02 -2.15e-01 3.60e-01
PRE NOTCH PROCESSING IN GOLGI 17 1.25e-01 2.15e-01 5.56e-01
MET ACTIVATES RAS SIGNALING 10 2.42e-01 -2.14e-01 6.78e-01
MITOCHONDRIAL TRANSLATION 93 3.68e-04 2.14e-01 1.26e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 1.52e-01 -2.14e-01 5.84e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 31 3.94e-02 2.14e-01 3.54e-01
MRNA SPLICING MINOR PATHWAY 52 8.72e-03 2.10e-01 1.39e-01
SHC MEDIATED CASCADE FGFR3 12 2.09e-01 2.10e-01 6.56e-01
INFLUENZA INFECTION 145 1.34e-05 2.10e-01 7.81e-04
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.47e-01 -2.09e-01 5.77e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 5.38e-05 2.09e-01 2.41e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 1.93e-01 2.09e-01 6.45e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 2.54e-01 2.08e-01 6.89e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 1.07e-01 -2.08e-01 5.33e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 11 2.33e-01 2.08e-01 6.72e-01
DARPP 32 EVENTS 23 8.77e-02 -2.06e-01 4.84e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 1.03e-01 -2.05e-01 5.22e-01
KERATAN SULFATE DEGRADATION 11 2.39e-01 2.05e-01 6.77e-01
RESPIRATORY ELECTRON TRANSPORT 102 3.79e-04 2.04e-01 1.26e-02
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 1.73e-01 2.03e-01 6.21e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 2.08e-01 2.02e-01 6.56e-01
GABA RECEPTOR ACTIVATION 52 1.21e-02 -2.01e-01 1.71e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 4.57e-02 -2.01e-01 3.84e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.11e-01 -2.01e-01 5.39e-01
CD28 DEPENDENT PI3K AKT SIGNALING 20 1.20e-01 -2.01e-01 5.56e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 2.11e-01 2.00e-01 6.59e-01
GLYCOGEN METABOLISM 25 8.59e-02 1.98e-01 4.84e-01
REGULATION OF IFNA SIGNALING 12 2.34e-01 -1.98e-01 6.72e-01
SIGNALING BY FGFR4 IN DISEASE 10 2.81e-01 -1.97e-01 7.03e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 1.38e-01 1.97e-01 5.60e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 1.90e-01 -1.96e-01 6.43e-01
LYSINE CATABOLISM 11 2.62e-01 1.95e-01 6.95e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 59 9.49e-03 -1.95e-01 1.50e-01
TRNA AMINOACYLATION 42 2.86e-02 1.95e-01 2.95e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 2.62e-01 -1.95e-01 6.95e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 13 2.23e-01 1.95e-01 6.69e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 1.42e-01 -1.94e-01 5.67e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 1.93e-01 -1.94e-01 6.45e-01
INTERFERON SIGNALING 160 2.26e-05 -1.94e-01 1.10e-03
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 1.94e-01 1.94e-01 6.45e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 4.43e-02 -1.94e-01 3.78e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 2.29e-01 1.93e-01 6.72e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 3.31e-02 1.92e-01 3.16e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 2.93e-01 1.92e-01 7.06e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 2.94e-01 -1.92e-01 7.07e-01
PYRUVATE METABOLISM 27 8.61e-02 -1.91e-01 4.84e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 1.45e-02 1.91e-01 1.91e-01
MITOTIC TELOPHASE CYTOKINESIS 13 2.35e-01 1.90e-01 6.72e-01
DERMATAN SULFATE BIOSYNTHESIS 11 2.80e-01 1.88e-01 7.03e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.81e-01 -1.88e-01 7.03e-01
NCAM1 INTERACTIONS 40 4.00e-02 1.88e-01 3.54e-01
SIGNALING BY ACTIVIN 12 2.62e-01 -1.87e-01 6.95e-01
SHC1 EVENTS IN EGFR SIGNALING 11 2.83e-01 -1.87e-01 7.03e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 1.22e-01 -1.86e-01 5.56e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 2.72e-02 1.86e-01 2.91e-01
LGI ADAM INTERACTIONS 14 2.28e-01 1.86e-01 6.72e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 3.10e-01 -1.85e-01 7.33e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 1.87e-01 1.85e-01 6.43e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 12 2.69e-01 -1.84e-01 7.01e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 6.86e-02 1.83e-01 4.49e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.29e-01 -1.83e-01 5.60e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 1.79e-01 1.83e-01 6.34e-01
PI 3K CASCADE FGFR3 12 2.75e-01 1.82e-01 7.03e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 1.39e-01 1.82e-01 5.62e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 310 3.82e-08 1.82e-01 3.43e-06
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 2.01e-02 -1.81e-01 2.36e-01
BILE ACID AND BILE SALT METABOLISM 25 1.20e-01 1.80e-01 5.56e-01
GLYCOGEN STORAGE DISEASES 12 2.81e-01 1.80e-01 7.03e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 2.45e-01 1.80e-01 6.85e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.65e-01 1.79e-01 6.08e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 2.82e-01 -1.79e-01 7.03e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.37e-01 1.79e-01 5.60e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 2.32e-01 1.78e-01 6.72e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 9.12e-02 -1.78e-01 4.87e-01
G PROTEIN BETA GAMMA SIGNALLING 30 9.14e-02 -1.78e-01 4.87e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 2.50e-01 -1.78e-01 6.88e-01
HDR THROUGH MMEJ ALT NHEJ 10 3.31e-01 1.77e-01 7.42e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 8.74e-02 1.77e-01 4.84e-01
PROCESSING OF SMDT1 16 2.19e-01 -1.77e-01 6.68e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 3.98e-02 -1.77e-01 3.54e-01
SIGNALING BY BMP 24 1.33e-01 -1.77e-01 5.60e-01
PLATELET CALCIUM HOMEOSTASIS 25 1.26e-01 -1.77e-01 5.57e-01
ACTIVATION OF BH3 ONLY PROTEINS 28 1.08e-01 -1.76e-01 5.34e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.37e-01 -1.75e-01 5.60e-01
SODIUM CALCIUM EXCHANGERS 10 3.38e-01 -1.75e-01 7.42e-01
COPII MEDIATED VESICLE TRANSPORT 66 1.40e-02 -1.75e-01 1.86e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.03e-01 -1.75e-01 5.22e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 2.76e-01 -1.74e-01 7.03e-01
CELLULAR HEXOSE TRANSPORT 11 3.17e-01 -1.74e-01 7.36e-01
RHOA GTPASE CYCLE 143 3.25e-04 1.74e-01 1.15e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 1.24e-01 1.74e-01 5.56e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 19 1.89e-01 1.74e-01 6.43e-01
FGFR2 ALTERNATIVE SPLICING 26 1.25e-01 1.74e-01 5.56e-01
SIGNALING BY ROBO RECEPTORS 205 2.25e-05 1.72e-01 1.10e-03
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.35e-01 -1.72e-01 6.72e-01
INTERLEUKIN 27 SIGNALING 10 3.50e-01 1.71e-01 7.50e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 60 2.27e-02 1.70e-01 2.57e-01
LONG TERM POTENTIATION 23 1.59e-01 -1.70e-01 6.00e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.89e-01 1.70e-01 6.43e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.01e-01 -1.69e-01 6.51e-01
ANTIMICROBIAL PEPTIDES 13 2.91e-01 1.69e-01 7.05e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 1.21e-01 -1.69e-01 5.56e-01
SELECTIVE AUTOPHAGY 72 1.32e-02 1.69e-01 1.80e-01
ENDOGENOUS STEROLS 21 1.81e-01 1.69e-01 6.36e-01
O LINKED GLYCOSYLATION OF MUCINS 41 6.31e-02 -1.68e-01 4.49e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 3.37e-01 -1.67e-01 7.42e-01
PHASE 0 RAPID DEPOLARISATION 31 1.07e-01 -1.67e-01 5.33e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 7.85e-02 -1.67e-01 4.77e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 4.52e-02 1.67e-01 3.82e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 23 1.67e-01 -1.66e-01 6.10e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 1.88e-02 -1.66e-01 2.27e-01
PURINE CATABOLISM 16 2.51e-01 1.66e-01 6.88e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.45e-01 1.65e-01 5.72e-01
MATURATION OF NUCLEOPROTEIN 10 3.68e-01 -1.64e-01 7.67e-01
EXTRACELLULAR MATRIX ORGANIZATION 242 1.17e-05 1.64e-01 7.17e-04
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 3.70e-01 -1.64e-01 7.67e-01
N GLYCAN ANTENNAE ELONGATION 15 2.80e-01 -1.61e-01 7.03e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 2.82e-01 -1.60e-01 7.03e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 3.18e-01 1.60e-01 7.37e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 2.05e-01 1.60e-01 6.53e-01
FORMATION OF APOPTOSOME 10 3.82e-01 -1.60e-01 7.74e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 3.62e-01 1.59e-01 7.63e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 8.69e-02 1.58e-01 4.84e-01
LAMININ INTERACTIONS 27 1.55e-01 1.58e-01 5.91e-01
G2 M DNA DAMAGE CHECKPOINT 65 2.83e-02 -1.57e-01 2.95e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 34 1.14e-01 1.57e-01 5.39e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 3.92e-01 -1.56e-01 7.76e-01
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.38e-01 1.56e-01 6.75e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 3.78e-02 1.56e-01 3.48e-01
METABOLISM OF RNA 643 1.67e-11 1.56e-01 9.75e-09
SIALIC ACID METABOLISM 32 1.27e-01 -1.56e-01 5.60e-01
THE NLRP3 INFLAMMASOME 15 3.00e-01 -1.55e-01 7.16e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 2.32e-01 -1.54e-01 6.72e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 13 3.37e-01 1.54e-01 7.42e-01
INTEGRIN CELL SURFACE INTERACTIONS 69 2.75e-02 1.54e-01 2.92e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 3.38e-01 -1.53e-01 7.42e-01
RHO GTPASES ACTIVATE PAKS 21 2.24e-01 1.53e-01 6.69e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.49e-01 -1.53e-01 6.88e-01
RHOC GTPASE CYCLE 73 2.46e-02 1.52e-01 2.70e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 3.63e-01 -1.52e-01 7.63e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 285 1.11e-05 -1.52e-01 7.17e-04
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.56e-02 -1.51e-01 2.76e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.67e-01 1.51e-01 7.01e-01
ACYL CHAIN REMODELLING OF PS 14 3.28e-01 -1.51e-01 7.42e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 3.88e-01 -1.50e-01 7.74e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.70e-01 1.50e-01 7.01e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 3.14e-01 -1.50e-01 7.36e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 2.99e-01 -1.50e-01 7.16e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 2.59e-01 -1.50e-01 6.92e-01
PENTOSE PHOSPHATE PATHWAY 13 3.50e-01 -1.50e-01 7.50e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 2.15e-01 -1.49e-01 6.63e-01
HEME SIGNALING 45 8.34e-02 -1.49e-01 4.84e-01
CDC42 GTPASE CYCLE 153 1.46e-03 1.49e-01 3.88e-02
RHOBTB2 GTPASE CYCLE 23 2.16e-01 1.49e-01 6.63e-01
FORMATION OF THE CORNIFIED ENVELOPE 29 1.66e-01 1.49e-01 6.08e-01
KERATINIZATION 29 1.66e-01 1.49e-01 6.08e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 2.90e-01 -1.48e-01 7.05e-01
PREGNENOLONE BIOSYNTHESIS 12 3.75e-01 1.48e-01 7.72e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 2.53e-01 -1.48e-01 6.88e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.39e-01 -1.48e-01 7.42e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 3.76e-01 1.48e-01 7.72e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 6.37e-02 1.47e-01 4.49e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.21e-01 -1.47e-01 7.94e-01
ERK MAPK TARGETS 22 2.35e-01 -1.46e-01 6.72e-01
HDACS DEACETYLATE HISTONES 45 8.97e-02 1.46e-01 4.86e-01
FRS MEDIATED FGFR3 SIGNALING 14 3.44e-01 1.46e-01 7.49e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 3.12e-01 1.46e-01 7.33e-01
VOLTAGE GATED POTASSIUM CHANNELS 40 1.11e-01 -1.46e-01 5.39e-01
RHOBTB3 ATPASE CYCLE 10 4.25e-01 -1.46e-01 7.94e-01
DISEASES OF IMMUNE SYSTEM 23 2.30e-01 1.45e-01 6.72e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 3.17e-01 -1.45e-01 7.36e-01
ERBB2 REGULATES CELL MOTILITY 14 3.50e-01 -1.44e-01 7.50e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 1.65e-01 1.44e-01 6.08e-01
INTERLEUKIN 10 SIGNALING 18 2.90e-01 -1.44e-01 7.05e-01
MITOPHAGY 29 1.83e-01 1.43e-01 6.40e-01
COSTIMULATION BY THE CD28 FAMILY 50 8.17e-02 -1.42e-01 4.82e-01
CA DEPENDENT EVENTS 36 1.40e-01 -1.42e-01 5.62e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 4.14e-01 1.42e-01 7.92e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 2.10e-01 -1.42e-01 6.59e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 2.73e-01 -1.42e-01 7.02e-01
CA2 PATHWAY 56 6.69e-02 -1.42e-01 4.49e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 107 1.17e-02 1.41e-01 1.71e-01
DEADENYLATION OF MRNA 25 2.22e-01 -1.41e-01 6.69e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 1.70e-02 1.41e-01 2.15e-01
DAP12 SIGNALING 24 2.32e-01 -1.41e-01 6.72e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 1.10e-01 -1.41e-01 5.39e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 15 3.45e-01 -1.41e-01 7.50e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 1.97e-01 1.41e-01 6.45e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 1.99e-01 1.40e-01 6.46e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 25 2.26e-01 -1.40e-01 6.71e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 4.04e-01 1.39e-01 7.85e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 49 9.23e-02 -1.39e-01 4.90e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 3.86e-01 -1.39e-01 7.74e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 5.20e-02 1.38e-01 4.13e-01
PROTEIN UBIQUITINATION 69 4.77e-02 -1.38e-01 3.87e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 6.80e-02 -1.37e-01 4.49e-01
MET RECEPTOR RECYCLING 10 4.52e-01 -1.37e-01 8.10e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 3.16e-01 1.36e-01 7.36e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 2.21e-01 -1.36e-01 6.69e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 3.47e-01 -1.36e-01 7.50e-01
HEDGEHOG ON STATE 82 3.48e-02 1.35e-01 3.27e-01
HEDGEHOG OFF STATE 106 1.67e-02 1.35e-01 2.15e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 6.77e-02 1.34e-01 4.49e-01
SIGNALING BY SCF KIT 41 1.38e-01 -1.34e-01 5.60e-01
ERKS ARE INACTIVATED 13 4.03e-01 -1.34e-01 7.85e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 4.42e-01 -1.34e-01 8.00e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 4.42e-01 -1.34e-01 8.00e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.55e-03 1.34e-01 5.95e-02
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 4.44e-01 -1.33e-01 8.02e-01
REGULATION OF TNFR1 SIGNALING 34 1.80e-01 1.33e-01 6.36e-01
NGF STIMULATED TRANSCRIPTION 37 1.63e-01 -1.33e-01 6.08e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.64e-01 1.32e-01 6.08e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.63e-01 1.32e-01 6.95e-01
SIGNALING BY WNT IN CANCER 31 2.03e-01 -1.32e-01 6.52e-01
ACYL CHAIN REMODELLING OF PE 16 3.61e-01 -1.32e-01 7.63e-01
HEME BIOSYNTHESIS 13 4.10e-01 -1.32e-01 7.90e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 1.22e-01 1.32e-01 5.56e-01
HEDGEHOG LIGAND BIOGENESIS 61 7.71e-02 1.31e-01 4.73e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 2.01e-01 1.31e-01 6.50e-01
INTERLEUKIN 6 FAMILY SIGNALING 19 3.26e-01 1.30e-01 7.42e-01
CELL JUNCTION ORGANIZATION 75 5.14e-02 -1.30e-01 4.11e-01
RHOB GTPASE CYCLE 67 6.63e-02 1.30e-01 4.49e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 4.18e-01 -1.30e-01 7.93e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 3.85e-01 1.30e-01 7.74e-01
HIV ELONGATION ARREST AND RECOVERY 32 2.06e-01 1.29e-01 6.53e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.30e-01 1.29e-01 5.60e-01
OLFACTORY SIGNALING PATHWAY 26 2.57e-01 1.28e-01 6.92e-01
RNA POLYMERASE I TRANSCRIPTION 67 7.08e-02 1.28e-01 4.49e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 4.85e-01 1.28e-01 8.33e-01
INTRA GOLGI TRAFFIC 43 1.48e-01 -1.28e-01 5.78e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 4.85e-01 -1.28e-01 8.33e-01
TRANSCRIPTIONAL REGULATION BY MECP2 60 8.83e-02 -1.27e-01 4.84e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.36e-01 1.27e-01 6.74e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 9.72e-02 -1.27e-01 5.04e-01
CRISTAE FORMATION 31 2.21e-01 1.27e-01 6.69e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 2.40e-01 -1.26e-01 6.77e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 4.75e-02 -1.26e-01 3.87e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 8.80e-02 -1.25e-01 4.84e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 6.84e-02 -1.25e-01 4.49e-01
METAL ION SLC TRANSPORTERS 24 2.89e-01 -1.25e-01 7.05e-01
RHOBTB GTPASE CYCLE 35 2.03e-01 1.24e-01 6.52e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 2.26e-01 1.24e-01 6.71e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.58e-01 -1.24e-01 6.92e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 34 2.12e-01 1.24e-01 6.59e-01
PHOSPHORYLATION OF THE APC C 17 3.78e-01 -1.24e-01 7.74e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 3.28e-01 -1.23e-01 7.42e-01
SIGNALING BY NTRK3 TRKC 17 3.79e-01 1.23e-01 7.74e-01
RESOLUTION OF ABASIC SITES AP SITES 37 1.95e-01 1.23e-01 6.45e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.58e-01 -1.23e-01 6.00e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 175 5.11e-03 -1.23e-01 1.05e-01
IRAK1 RECRUITS IKK COMPLEX 14 4.27e-01 1.23e-01 7.94e-01
SIGNALING BY HEDGEHOG 141 1.20e-02 1.23e-01 1.71e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 4.12e-01 1.22e-01 7.90e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 6.54e-02 -1.22e-01 4.49e-01
SIGNALING BY PDGF 56 1.13e-01 1.22e-01 5.39e-01
PLATELET HOMEOSTASIS 76 6.57e-02 -1.22e-01 4.49e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 89 4.72e-02 1.22e-01 3.87e-01
MET PROMOTES CELL MOTILITY 39 1.89e-01 1.22e-01 6.43e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 3.85e-01 1.22e-01 7.74e-01
STRIATED MUSCLE CONTRACTION 27 2.78e-01 1.21e-01 7.03e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 3.08e-01 -1.20e-01 7.28e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 4.21e-01 1.20e-01 7.94e-01
PLASMA LIPOPROTEIN REMODELING 17 3.91e-01 -1.20e-01 7.76e-01
METHYLATION 11 4.91e-01 1.20e-01 8.40e-01
SIGNALING BY MET 75 7.31e-02 1.20e-01 4.59e-01
CILIUM ASSEMBLY 189 4.61e-03 1.20e-01 9.76e-02
DAP12 INTERACTIONS 29 2.68e-01 -1.19e-01 7.01e-01
INTERLEUKIN 15 SIGNALING 12 4.76e-01 -1.19e-01 8.26e-01
SIGNALING BY FGFR2 64 1.01e-01 1.19e-01 5.18e-01
SIGNALING BY NTRK2 TRKB 24 3.15e-01 -1.19e-01 7.36e-01
DEGRADATION OF DVL 55 1.29e-01 1.18e-01 5.60e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 1.36e-01 1.18e-01 5.60e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.17e-01 -1.17e-01 6.63e-01
GLUCONEOGENESIS 27 2.93e-01 1.17e-01 7.06e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 3.91e-01 1.17e-01 7.76e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 3.33e-01 1.17e-01 7.42e-01
ACYL CHAIN REMODELLING OF PG 10 5.23e-01 -1.17e-01 8.60e-01
UNFOLDED PROTEIN RESPONSE UPR 85 6.41e-02 1.16e-01 4.49e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 43 1.87e-01 -1.16e-01 6.43e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 2.71e-01 1.16e-01 7.02e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 342 2.29e-04 -1.16e-01 8.62e-03
CARNITINE METABOLISM 14 4.52e-01 -1.16e-01 8.10e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 10 5.26e-01 -1.16e-01 8.60e-01
SIGNALING BY CSF3 G CSF 29 2.82e-01 -1.15e-01 7.03e-01
KINESINS 47 1.72e-01 1.15e-01 6.21e-01
EPHB MEDIATED FORWARD SIGNALING 42 1.98e-01 -1.15e-01 6.45e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 3.22e-01 -1.14e-01 7.41e-01
EARLY PHASE OF HIV LIFE CYCLE 14 4.59e-01 -1.14e-01 8.11e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 6.92e-02 1.14e-01 4.49e-01
NRAGE SIGNALS DEATH THROUGH JNK 56 1.41e-01 1.14e-01 5.65e-01
RAF ACTIVATION 34 2.52e-01 -1.14e-01 6.88e-01
PEPTIDE HORMONE METABOLISM 59 1.34e-01 -1.13e-01 5.60e-01
CARGO CONCENTRATION IN THE ER 31 2.80e-01 -1.12e-01 7.03e-01
NEPHRIN FAMILY INTERACTIONS 22 3.64e-01 1.12e-01 7.63e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 1.45e-01 1.12e-01 5.72e-01
MICRORNA MIRNA BIOGENESIS 24 3.45e-01 1.11e-01 7.50e-01
OTHER SEMAPHORIN INTERACTIONS 19 4.00e-01 -1.11e-01 7.83e-01
FOXO MEDIATED TRANSCRIPTION 60 1.36e-01 -1.11e-01 5.60e-01
POTASSIUM CHANNELS 90 6.87e-02 -1.11e-01 4.49e-01
RAC1 GTPASE CYCLE 177 1.12e-02 1.11e-01 1.70e-01
SLC TRANSPORTER DISORDERS 69 1.12e-01 -1.11e-01 5.39e-01
RHOU GTPASE CYCLE 33 2.72e-01 -1.11e-01 7.02e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 4.74e-01 1.10e-01 8.25e-01
IRON UPTAKE AND TRANSPORT 51 1.73e-01 -1.10e-01 6.21e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 3.33e-01 -1.10e-01 7.42e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 4.78e-01 -1.09e-01 8.28e-01
NEGATIVE REGULATION OF FLT3 14 4.78e-01 1.09e-01 8.28e-01
HSF1 ACTIVATION 26 3.35e-01 1.09e-01 7.42e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 2.05e-01 -1.09e-01 6.53e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 3.46e-01 1.09e-01 7.50e-01
NEDDYLATION 217 5.82e-03 -1.09e-01 1.14e-01
KILLING MECHANISMS 10 5.52e-01 1.08e-01 8.72e-01
TNFR2 NON CANONICAL NF KB PATHWAY 80 9.36e-02 1.08e-01 4.94e-01
RND1 GTPASE CYCLE 38 2.48e-01 -1.08e-01 6.88e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 3.69e-01 -1.08e-01 7.67e-01
RESOLUTION OF D LOOP STRUCTURES 30 3.05e-01 -1.08e-01 7.26e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 3.80e-01 -1.08e-01 7.74e-01
GAP JUNCTION DEGRADATION 11 5.38e-01 1.07e-01 8.66e-01
INSULIN RECEPTOR RECYCLING 20 4.09e-01 -1.07e-01 7.89e-01
O LINKED GLYCOSYLATION 86 8.77e-02 -1.07e-01 4.84e-01
FLT3 SIGNALING 36 2.69e-01 -1.06e-01 7.01e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 5.43e-01 1.06e-01 8.71e-01
SIGNALING BY ERBB2 IN CANCER 25 3.59e-01 -1.06e-01 7.62e-01
EGFR DOWNREGULATION 28 3.34e-01 -1.06e-01 7.42e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 1.50e-01 -1.05e-01 5.79e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 2.45e-01 1.05e-01 6.85e-01
SIGNALING BY PDGFR IN DISEASE 20 4.18e-01 -1.05e-01 7.93e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 2.02e-01 -1.04e-01 6.51e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.25e-01 1.04e-01 7.42e-01
INTERLEUKIN 7 SIGNALING 20 4.23e-01 -1.03e-01 7.94e-01
COHESIN LOADING ONTO CHROMATIN 10 5.73e-01 1.03e-01 8.80e-01
G ALPHA I SIGNALLING EVENTS 193 1.39e-02 -1.03e-01 1.86e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 4.51e-01 -1.03e-01 8.10e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 5.74e-01 -1.03e-01 8.80e-01
MEIOTIC RECOMBINATION 38 2.75e-01 -1.02e-01 7.03e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 1.75e-01 1.02e-01 6.24e-01
STABILIZATION OF P53 54 1.95e-01 1.02e-01 6.45e-01
CYTOPROTECTION BY HMOX1 119 5.50e-02 1.02e-01 4.27e-01
METABOLISM OF FOLATE AND PTERINES 15 4.95e-01 1.02e-01 8.44e-01
BASE EXCISION REPAIR 56 1.89e-01 1.02e-01 6.43e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 1.37e-01 -1.01e-01 5.60e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 1.09e-01 1.01e-01 5.36e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 45 2.41e-01 1.01e-01 6.77e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 1.87e-01 1.01e-01 6.43e-01
HCMV EARLY EVENTS 79 1.21e-01 1.01e-01 5.56e-01
SENSORY PROCESSING OF SOUND 61 1.73e-01 1.01e-01 6.21e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 5.29e-01 1.01e-01 8.61e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.24e-01 1.00e-01 6.69e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 281 3.90e-03 1.00e-01 8.59e-02
INTEGRIN SIGNALING 24 3.96e-01 1.00e-01 7.79e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 12 5.48e-01 -1.00e-01 8.71e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 5.84e-01 1.00e-01 8.80e-01
PEROXISOMAL PROTEIN IMPORT 57 1.93e-01 -9.98e-02 6.45e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 9.58e-02 -9.84e-02 4.99e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.55e-01 -9.84e-02 8.73e-01
CHOLESTEROL BIOSYNTHESIS 24 4.05e-01 -9.83e-02 7.85e-01
SIGNALLING TO ERKS 34 3.22e-01 -9.82e-02 7.41e-01
RNA POLYMERASE III CHAIN ELONGATION 18 4.71e-01 9.81e-02 8.21e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 5.57e-01 9.80e-02 8.74e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 149 3.97e-02 9.77e-02 3.54e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 5.59e-01 9.73e-02 8.77e-01
THE PHOTOTRANSDUCTION CASCADE 21 4.41e-01 -9.71e-02 8.00e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 5.45e-01 -9.71e-02 8.71e-01
SULFUR AMINO ACID METABOLISM 22 4.32e-01 9.69e-02 7.94e-01
RHOBTB1 GTPASE CYCLE 23 4.22e-01 9.67e-02 7.94e-01
INTERLEUKIN 17 SIGNALING 66 1.75e-01 -9.66e-02 6.24e-01
PLATELET AGGREGATION PLUG FORMATION 33 3.38e-01 9.64e-02 7.42e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 1.90e-01 -9.62e-02 6.43e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 3.18e-01 -9.61e-02 7.37e-01
GLYCOGEN SYNTHESIS 14 5.36e-01 9.56e-02 8.66e-01
MITOTIC PROPHASE 92 1.13e-01 -9.56e-02 5.39e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 1.13e-01 -9.53e-02 5.39e-01
NETRIN 1 SIGNALING 49 2.49e-01 -9.51e-02 6.88e-01
POTENTIAL THERAPEUTICS FOR SARS 76 1.53e-01 9.49e-02 5.86e-01
ASSEMBLY OF THE HIV VIRION 16 5.13e-01 9.46e-02 8.55e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 3.87e-01 -9.45e-02 7.74e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.49e-01 9.44e-02 5.79e-01
MITOCHONDRIAL PROTEIN IMPORT 63 1.96e-01 9.43e-02 6.45e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 4.15e-01 9.42e-02 7.93e-01
AUTOPHAGY 138 5.71e-02 9.39e-02 4.34e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 4.08e-01 9.38e-02 7.89e-01
INWARDLY RECTIFYING K CHANNELS 31 3.70e-01 -9.30e-02 7.67e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 4.13e-01 9.27e-02 7.92e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.71e-01 -9.27e-02 6.21e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 17 5.09e-01 9.26e-02 8.52e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.52e-01 -9.26e-02 8.10e-01
NUCLEOTIDE SALVAGE 21 4.64e-01 -9.24e-02 8.14e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 3.38e-01 -9.24e-02 7.42e-01
PROTEIN FOLDING 89 1.33e-01 9.22e-02 5.60e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 4.35e-01 9.22e-02 7.95e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 5.81e-01 -9.20e-02 8.80e-01
BIOLOGICAL OXIDATIONS 123 7.89e-02 9.18e-02 4.77e-01
ZINC TRANSPORTERS 15 5.39e-01 -9.15e-02 8.67e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 3.95e-01 9.13e-02 7.79e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 597 1.52e-04 9.11e-02 6.34e-03
DEGRADATION OF AXIN 53 2.52e-01 9.10e-02 6.88e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 5.86e-01 9.08e-02 8.80e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 3.69e-01 9.04e-02 7.67e-01
MEIOTIC SYNAPSIS 39 3.30e-01 9.02e-02 7.42e-01
INTERLEUKIN 1 FAMILY SIGNALING 124 8.46e-02 8.98e-02 4.84e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 4.29e-01 -8.96e-02 7.94e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 5.23e-01 -8.95e-02 8.60e-01
SIGNALING BY NTRKS 131 7.75e-02 -8.94e-02 4.73e-01
ABC TRANSPORTER DISORDERS 71 1.93e-01 8.94e-02 6.45e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 4.59e-01 8.93e-02 8.11e-01
DUAL INCISION IN GG NER 40 3.29e-01 8.93e-02 7.42e-01
CITRIC ACID CYCLE TCA CYCLE 22 4.71e-01 8.88e-02 8.21e-01
SEMAPHORIN INTERACTIONS 64 2.20e-01 8.87e-02 6.68e-01
AURKA ACTIVATION BY TPX2 71 1.97e-01 8.86e-02 6.45e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 3.28e-01 8.83e-02 7.42e-01
ANTIGEN PROCESSING CROSS PRESENTATION 93 1.42e-01 8.81e-02 5.67e-01
CTLA4 INHIBITORY SIGNALING 20 4.98e-01 -8.76e-02 8.45e-01
GP1B IX V ACTIVATION SIGNALLING 11 6.15e-01 8.75e-02 8.93e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 5.45e-01 -8.73e-02 8.71e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 3.91e-01 -8.63e-02 7.76e-01
NICOTINAMIDE SALVAGING 15 5.66e-01 8.57e-02 8.79e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1209 8.46e-07 -8.49e-02 6.58e-05
MITOTIC G2 G2 M PHASES 184 4.75e-02 8.48e-02 3.87e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 4.55e-01 -8.47e-02 8.10e-01
EPHRIN SIGNALING 19 5.23e-01 -8.46e-02 8.60e-01
POLYMERASE SWITCHING 14 5.84e-01 8.46e-02 8.80e-01
NERVOUS SYSTEM DEVELOPMENT 547 7.57e-04 8.45e-02 2.26e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 3.33e-01 8.44e-02 7.42e-01
MUCOPOLYSACCHARIDOSES 11 6.28e-01 -8.44e-02 8.99e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.03e-01 -8.44e-02 8.50e-01
SIGNALING BY INSULIN RECEPTOR 61 2.56e-01 -8.42e-02 6.90e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 2.49e-01 8.40e-02 6.88e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 3.77e-01 -8.39e-02 7.74e-01
CARDIAC CONDUCTION 108 1.34e-01 -8.36e-02 5.60e-01
INTRINSIC PATHWAY FOR APOPTOSIS 50 3.07e-01 -8.36e-02 7.28e-01
CELL CELL COMMUNICATION 107 1.36e-01 -8.34e-02 5.60e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 2.68e-01 8.34e-02 7.01e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 235 2.94e-02 -8.26e-02 2.96e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 5.81e-01 8.24e-02 8.80e-01
CRMPS IN SEMA3A SIGNALING 16 5.69e-01 -8.23e-02 8.80e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 3.59e-01 -8.19e-02 7.62e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.38e-01 -8.19e-02 9.01e-01
ASPARAGINE N LINKED GLYCOSYLATION 283 1.84e-02 -8.16e-02 2.27e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 51 3.15e-01 -8.14e-02 7.36e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 5.50e-01 -8.13e-02 8.71e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 5.86e-01 -8.13e-02 8.80e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 5.31e-01 8.10e-02 8.61e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 5.75e-01 -8.09e-02 8.80e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 5.02e-01 8.08e-02 8.49e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 4.67e-01 -8.08e-02 8.19e-01
TELOMERE EXTENSION BY TELOMERASE 23 5.05e-01 8.04e-02 8.50e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 2.88e-01 8.01e-02 7.05e-01
VISUAL PHOTOTRANSDUCTION 61 2.81e-01 -7.99e-02 7.03e-01
G1 S DNA DAMAGE CHECKPOINTS 65 2.67e-01 7.97e-02 7.01e-01
METABOLISM OF PORPHYRINS 19 5.49e-01 -7.95e-02 8.71e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 2.89e-01 7.91e-02 7.05e-01
DAG AND IP3 SIGNALING 40 3.88e-01 -7.90e-02 7.74e-01
OPIOID SIGNALLING 86 2.09e-01 -7.85e-02 6.56e-01
SHC MEDIATED CASCADE FGFR4 10 6.68e-01 7.83e-02 9.12e-01
METABOLISM OF NUCLEOTIDES 91 1.98e-01 -7.82e-02 6.45e-01
TNF SIGNALING 43 3.76e-01 7.81e-02 7.72e-01
RECYCLING PATHWAY OF L1 40 3.94e-01 7.79e-02 7.79e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 2.49e-01 7.75e-02 6.88e-01
SYNTHESIS OF PC 25 5.05e-01 7.70e-02 8.50e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 108 1.67e-01 7.70e-02 6.10e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 2.95e-01 7.70e-02 7.08e-01
REGULATION OF FZD BY UBIQUITINATION 19 5.61e-01 -7.70e-02 8.78e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 94 1.97e-01 -7.70e-02 6.45e-01
SIGNALING BY FGFR 74 2.53e-01 7.69e-02 6.88e-01
RNA POLYMERASE III TRANSCRIPTION 41 3.94e-01 7.69e-02 7.79e-01
NEURONAL SYSTEM 363 1.27e-02 -7.64e-02 1.76e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 6.22e-01 -7.62e-02 8.93e-01
PCP CE PATHWAY 90 2.13e-01 7.60e-02 6.59e-01
HDMS DEMETHYLATE HISTONES 27 4.94e-01 -7.60e-02 8.44e-01
DSCAM INTERACTIONS 11 6.63e-01 -7.58e-02 9.12e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 4.32e-01 -7.57e-02 7.94e-01
ADAPTIVE IMMUNE SYSTEM 599 1.62e-03 -7.57e-02 4.20e-02
DISEASES OF METABOLISM 199 6.59e-02 7.57e-02 4.49e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.59e-01 7.56e-02 8.11e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 169 9.04e-02 -7.56e-02 4.86e-01
RHOV GTPASE CYCLE 32 4.60e-01 -7.55e-02 8.11e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 5.70e-01 -7.54e-02 8.80e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 4.85e-01 -7.50e-02 8.33e-01
CD209 DC SIGN SIGNALING 18 5.83e-01 -7.48e-02 8.80e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 1.37e-01 -7.47e-02 5.60e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 2.23e-01 7.47e-02 6.69e-01
IRS MEDIATED SIGNALLING 37 4.32e-01 -7.46e-02 7.94e-01
CELLULAR RESPONSE TO HYPOXIA 71 2.80e-01 7.42e-02 7.03e-01
PTEN REGULATION 134 1.39e-01 7.42e-02 5.62e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 5.86e-01 7.41e-02 8.80e-01
BASIGIN INTERACTIONS 22 5.47e-01 -7.41e-02 8.71e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 6.20e-01 -7.40e-02 8.93e-01
INTRAFLAGELLAR TRANSPORT 49 3.71e-01 7.40e-02 7.67e-01
SIGNALING BY NOTCH2 33 4.63e-01 -7.39e-02 8.14e-01
ENOS ACTIVATION 11 6.73e-01 -7.36e-02 9.12e-01
REGULATION OF PTEN GENE TRANSCRIPTION 59 3.28e-01 7.36e-02 7.42e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 5.90e-01 -7.34e-02 8.83e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 5.61e-01 7.34e-02 8.78e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 6.36e-01 7.31e-02 9.01e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 5.45e-01 7.29e-02 8.71e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 2.41e-01 -7.28e-02 6.77e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 6.77e-01 7.26e-02 9.13e-01
ION HOMEOSTASIS 48 3.85e-01 -7.25e-02 7.74e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 5.31e-01 7.23e-02 8.61e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 3.58e-01 7.23e-02 7.62e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 5.01e-01 -7.22e-02 8.49e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 4.60e-01 7.21e-02 8.11e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 6.53e-01 7.20e-02 9.12e-01
G1 S SPECIFIC TRANSCRIPTION 26 5.26e-01 -7.18e-02 8.60e-01
REGULATED PROTEOLYSIS OF P75NTR 12 6.67e-01 7.18e-02 9.12e-01
METABOLISM OF POLYAMINES 57 3.50e-01 7.16e-02 7.50e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 5.12e-01 7.16e-02 8.55e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 4.46e-01 7.15e-02 8.04e-01
RHOG GTPASE CYCLE 73 2.91e-01 7.15e-02 7.05e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 6.47e-01 -7.08e-02 9.06e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 21 5.75e-01 -7.07e-02 8.80e-01
CHONDROITIN SULFATE BIOSYNTHESIS 19 5.95e-01 -7.05e-02 8.86e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 6.37e-01 7.04e-02 9.01e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 3.63e-01 -7.03e-02 7.63e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 5.06e-01 -7.02e-02 8.51e-01
ESR MEDIATED SIGNALING 163 1.25e-01 -6.97e-02 5.56e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 4.96e-01 -6.95e-02 8.44e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 2.99e-01 6.93e-02 7.16e-01
RHO GTPASES ACTIVATE KTN1 11 6.91e-01 6.93e-02 9.17e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.33e-01 -6.91e-02 7.94e-01
PI METABOLISM 79 2.90e-01 -6.90e-02 7.05e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 5.86e-01 -6.86e-02 8.80e-01
NUCLEAR ENVELOPE NE REASSEMBLY 63 3.46e-01 6.86e-02 7.50e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 5.30e-01 -6.85e-02 8.61e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 90 2.64e-01 -6.81e-02 6.98e-01
TP53 REGULATES METABOLIC GENES 84 2.85e-01 -6.76e-02 7.03e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 2.38e-01 6.74e-02 6.75e-01
MITOTIC PROMETAPHASE 175 1.25e-01 6.72e-02 5.56e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 4.11e-01 6.72e-02 7.90e-01
G PROTEIN MEDIATED EVENTS 52 4.02e-01 -6.72e-02 7.85e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 6.43e-01 6.69e-02 9.03e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 6.34e-01 -6.68e-02 9.01e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 6.06e-01 6.67e-02 8.89e-01
INTERLEUKIN 35 SIGNALLING 10 7.15e-01 6.66e-02 9.24e-01
SHC MEDIATED CASCADE FGFR1 15 6.57e-01 6.63e-02 9.12e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 7.04e-01 6.63e-02 9.22e-01
UCH PROTEINASES 88 2.86e-01 6.59e-02 7.04e-01
S PHASE 153 1.60e-01 -6.58e-02 6.02e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 6.81e-01 6.58e-02 9.13e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 6.94e-01 6.57e-02 9.18e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 5.14e-01 6.56e-02 8.55e-01
NICOTINATE METABOLISM 24 5.78e-01 6.56e-02 8.80e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 2.71e-01 6.53e-02 7.02e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 4.21e-01 -6.51e-02 7.94e-01
GLYCOSAMINOGLYCAN METABOLISM 114 2.32e-01 -6.49e-02 6.72e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 7.11e-01 -6.45e-02 9.24e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 5.70e-01 -6.44e-02 8.80e-01
DEVELOPMENTAL BIOLOGY 811 2.12e-03 6.39e-02 5.11e-02
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 4.70e-01 -6.37e-02 8.21e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 4.50e-01 6.36e-02 8.10e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 3.60e-01 6.33e-02 7.62e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 176 1.49e-01 6.31e-02 5.79e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 3.81e-01 6.29e-02 7.74e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 5.21e-01 -6.27e-02 8.60e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 3.80e-01 6.25e-02 7.74e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 5.08e-01 6.20e-02 8.52e-01
OTHER INTERLEUKIN SIGNALING 20 6.32e-01 6.19e-02 9.00e-01
SIGNALING BY RETINOIC ACID 33 5.38e-01 -6.19e-02 8.66e-01
HCMV INFECTION 102 2.81e-01 6.18e-02 7.03e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 5.54e-01 6.15e-02 8.73e-01
GLUCAGON TYPE LIGAND RECEPTORS 23 6.11e-01 -6.14e-02 8.93e-01
SARS COV 1 INFECTION 48 4.64e-01 6.11e-02 8.14e-01
RHOQ GTPASE CYCLE 58 4.22e-01 6.10e-02 7.94e-01
SIGNALLING TO RAS 20 6.37e-01 6.10e-02 9.01e-01
INTERLEUKIN 1 SIGNALING 95 3.05e-01 6.09e-02 7.26e-01
NONHOMOLOGOUS END JOINING NHEJ 43 4.90e-01 -6.09e-02 8.40e-01
G2 M CHECKPOINTS 133 2.29e-01 -6.05e-02 6.72e-01
SIGNALING BY FGFR2 IIIA TM 19 6.49e-01 6.04e-02 9.08e-01
GLUTATHIONE CONJUGATION 29 5.75e-01 6.02e-02 8.80e-01
LAGGING STRAND SYNTHESIS 20 6.42e-01 6.01e-02 9.02e-01
HOMOLOGY DIRECTED REPAIR 107 2.84e-01 -6.00e-02 7.03e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 6.98e-01 5.99e-02 9.21e-01
PI3K AKT SIGNALING IN CANCER 89 3.31e-01 -5.97e-02 7.42e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 6.80e-01 -5.96e-02 9.13e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 5.66e-01 -5.96e-02 8.79e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 4.55e-01 -5.93e-02 8.10e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.23e-01 -5.92e-02 9.27e-01
CHROMATIN MODIFYING ENZYMES 217 1.34e-01 5.91e-02 5.60e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 6.67e-01 5.85e-02 9.12e-01
TRANS GOLGI NETWORK VESICLE BUDDING 70 3.98e-01 -5.85e-02 7.82e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 7.37e-01 5.84e-02 9.35e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 6.21e-01 5.84e-02 8.93e-01
SIGNALING BY ERYTHROPOIETIN 24 6.21e-01 5.84e-02 8.93e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.44e-01 5.83e-02 9.03e-01
MITOCHONDRIAL BIOGENESIS 92 3.34e-01 5.83e-02 7.42e-01
INOSITOL PHOSPHATE METABOLISM 47 4.90e-01 5.82e-02 8.40e-01
SIGNAL AMPLIFICATION 30 5.82e-01 -5.81e-02 8.80e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 62 4.31e-01 -5.79e-02 7.94e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 3.60e-01 5.79e-02 7.62e-01
PARASITE INFECTION 55 4.60e-01 -5.76e-02 8.11e-01
TRIGLYCERIDE CATABOLISM 14 7.11e-01 -5.72e-02 9.24e-01
SEPARATION OF SISTER CHROMATIDS 165 2.06e-01 5.72e-02 6.53e-01
RESOLUTION OF SISTER CHROMATID COHESION 100 3.25e-01 5.70e-02 7.42e-01
GPCR LIGAND BINDING 261 1.17e-01 -5.65e-02 5.50e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 2.55e-01 -5.58e-02 6.90e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 5.75e-01 -5.55e-02 8.80e-01
RHO GTPASE CYCLE 427 5.05e-02 5.54e-02 4.06e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 3.87e-01 5.53e-02 7.74e-01
RAS PROCESSING 24 6.39e-01 5.53e-02 9.01e-01
SIGNALING BY FGFR3 34 5.78e-01 5.51e-02 8.80e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 1.90e-02 5.51e-02 2.27e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 4.32e-01 -5.48e-02 7.94e-01
ARACHIDONIC ACID METABOLISM 40 5.51e-01 5.45e-02 8.71e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 6.73e-01 5.45e-02 9.12e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 180 2.10e-01 -5.42e-02 6.59e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 6.14e-01 5.42e-02 8.93e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 4.37e-01 5.42e-02 7.96e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 7.18e-01 5.39e-02 9.24e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 6.56e-01 5.37e-02 9.12e-01
HS GAG BIOSYNTHESIS 29 6.18e-01 -5.35e-02 8.93e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 6.72e-01 -5.35e-02 9.12e-01
GENERATION OF SECOND MESSENGER MOLECULES 20 6.79e-01 5.34e-02 9.13e-01
DNA REPAIR 291 1.18e-01 -5.33e-02 5.54e-01
REGULATION OF RAS BY GAPS 66 4.54e-01 5.33e-02 8.10e-01
NEGATIVE REGULATION OF MAPK PATHWAY 43 5.46e-01 -5.33e-02 8.71e-01
GABA B RECEPTOR ACTIVATION 39 5.65e-01 -5.32e-02 8.79e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 6.81e-01 -5.31e-02 9.13e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 7.22e-01 -5.30e-02 9.27e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 6.82e-01 -5.30e-02 9.13e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 5.77e-01 -5.30e-02 8.80e-01
NUCLEAR ENVELOPE BREAKDOWN 47 5.31e-01 -5.29e-02 8.61e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 6.54e-01 -5.28e-02 9.12e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 6.17e-01 -5.28e-02 8.93e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 7.63e-01 5.25e-02 9.45e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 6.13e-01 -5.25e-02 8.93e-01
SYNTHESIS OF PA 29 6.26e-01 5.23e-02 8.97e-01
PLASMA LIPOPROTEIN CLEARANCE 27 6.41e-01 5.19e-02 9.02e-01
GPVI MEDIATED ACTIVATION CASCADE 31 6.17e-01 5.19e-02 8.93e-01
HIV TRANSCRIPTION ELONGATION 42 5.62e-01 5.17e-02 8.78e-01
SUMOYLATION 162 2.58e-01 -5.15e-02 6.92e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 117 3.36e-01 5.15e-02 7.42e-01
PYROPTOSIS 20 6.91e-01 -5.14e-02 9.17e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 4.23e-01 5.12e-02 7.94e-01
FCERI MEDIATED NF KB ACTIVATION 76 4.41e-01 5.11e-02 8.00e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 6.59e-01 5.10e-02 9.12e-01
MYOGENESIS 25 6.59e-01 -5.09e-02 9.12e-01
FATTY ACYL COA BIOSYNTHESIS 32 6.19e-01 5.08e-02 8.93e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 7.61e-01 5.07e-02 9.45e-01
NOD1 2 SIGNALING PATHWAY 35 6.04e-01 5.07e-02 8.89e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 82 4.28e-01 -5.07e-02 7.94e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 92 4.05e-01 5.03e-02 7.85e-01
NUCLEOBASE BIOSYNTHESIS 15 7.37e-01 -5.02e-02 9.35e-01
DISEASES OF PROGRAMMED CELL DEATH 54 5.25e-01 5.01e-02 8.60e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 3.99e-01 5.01e-02 7.83e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 7.06e-01 -5.00e-02 9.22e-01
MAPK6 MAPK4 SIGNALING 83 4.32e-01 4.99e-02 7.94e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 4.10e-01 -4.98e-02 7.90e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 5.78e-01 -4.97e-02 8.80e-01
PLATELET SENSITIZATION BY LDL 15 7.39e-01 4.96e-02 9.35e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 5.84e-01 4.95e-02 8.80e-01
MITOTIC METAPHASE AND ANAPHASE 205 2.27e-01 4.90e-02 6.71e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.36e-01 -4.89e-02 7.96e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 7.14e-01 4.86e-02 9.24e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 4.24e-01 -4.85e-02 7.94e-01
NUCLEAR IMPORT OF REV PROTEIN 32 6.36e-01 -4.84e-02 9.01e-01
RNA POLYMERASE II TRANSCRIPTION 1084 7.84e-03 -4.82e-02 1.32e-01
REGULATION OF BACH1 ACTIVITY 11 7.82e-01 -4.81e-02 9.50e-01
PHASE 2 PLATEAU PHASE 13 7.64e-01 -4.81e-02 9.45e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 7.74e-01 4.78e-02 9.48e-01
SIGNALING BY GPCR 478 7.42e-02 -4.78e-02 4.63e-01
MTORC1 MEDIATED SIGNALLING 24 6.87e-01 4.76e-02 9.17e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 7.07e-01 -4.74e-02 9.22e-01
DNA REPLICATION 121 3.68e-01 -4.74e-02 7.67e-01
HCMV LATE EVENTS 64 5.13e-01 -4.73e-02 8.55e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 7.96e-01 4.73e-02 9.53e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 4.00e-01 -4.69e-02 7.83e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 6.17e-01 4.69e-02 8.93e-01
TRANSPORT OF SMALL MOLECULES 568 5.77e-02 -4.68e-02 4.34e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.11e-01 -4.68e-02 9.24e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 7.46e-01 4.67e-02 9.40e-01
METALLOPROTEASE DUBS 25 6.86e-01 -4.67e-02 9.17e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 5.35e-01 4.67e-02 8.66e-01
PRC2 METHYLATES HISTONES AND DNA 29 6.66e-01 4.64e-02 9.12e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 7.56e-01 -4.63e-02 9.43e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.91e-01 -4.63e-02 9.53e-01
RAB REGULATION OF TRAFFICKING 118 3.87e-01 -4.62e-02 7.74e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 7.02e-01 4.61e-02 9.22e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 6.01e-01 4.61e-02 8.89e-01
PI 3K CASCADE FGFR2 16 7.49e-01 4.61e-02 9.40e-01
DEATH RECEPTOR SIGNALLING 134 3.59e-01 4.60e-02 7.62e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 141 3.48e-01 -4.58e-02 7.50e-01
RHO GTPASE EFFECTORS 247 2.16e-01 4.58e-02 6.63e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 7.93e-01 -4.57e-02 9.53e-01
BUDDING AND MATURATION OF HIV VIRION 27 6.81e-01 4.57e-02 9.13e-01
APOPTOTIC EXECUTION PHASE 45 5.96e-01 -4.57e-02 8.86e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 7.17e-01 -4.56e-02 9.24e-01
VXPX CARGO TARGETING TO CILIUM 19 7.31e-01 4.55e-02 9.33e-01
SARS COV 2 INFECTION 65 5.26e-01 -4.55e-02 8.60e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 7.39e-01 4.54e-02 9.35e-01
PI 3K CASCADE FGFR4 10 8.04e-01 4.54e-02 9.55e-01
TRANSCRIPTION OF THE HIV GENOME 67 5.24e-01 4.50e-02 8.60e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 6.92e-01 4.48e-02 9.18e-01
DNA STRAND ELONGATION 32 6.62e-01 -4.47e-02 9.12e-01
LYSOSOME VESICLE BIOGENESIS 33 6.58e-01 4.45e-02 9.12e-01
SIGNALING BY LEPTIN 10 8.08e-01 4.43e-02 9.56e-01
PI 3K CASCADE FGFR1 15 7.67e-01 4.43e-02 9.45e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 540 8.02e-02 -4.42e-02 4.80e-01
NUCLEAR SIGNALING BY ERBB4 31 6.71e-01 4.41e-02 9.12e-01
SIGNALING BY NUCLEAR RECEPTORS 220 2.61e-01 -4.41e-02 6.95e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 6.63e-01 4.38e-02 9.12e-01
METABOLISM OF COFACTORS 18 7.48e-01 4.37e-02 9.40e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 6.90e-01 4.36e-02 9.17e-01
FANCONI ANEMIA PATHWAY 36 6.53e-01 4.33e-02 9.12e-01
STIMULI SENSING CHANNELS 74 5.20e-01 -4.32e-02 8.60e-01
G ALPHA Z SIGNALLING EVENTS 45 6.16e-01 -4.32e-02 8.93e-01
TRIGLYCERIDE METABOLISM 22 7.27e-01 -4.30e-02 9.29e-01
SIGNALING BY PTK6 50 5.99e-01 4.29e-02 8.89e-01
L1CAM INTERACTIONS 109 4.40e-01 4.28e-02 8.00e-01
PEROXISOMAL LIPID METABOLISM 26 7.06e-01 -4.28e-02 9.22e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 5.90e-01 4.24e-02 8.83e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 7.50e-01 4.23e-02 9.40e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 51 6.01e-01 -4.23e-02 8.89e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 7.04e-01 -4.23e-02 9.22e-01
INFECTIOUS DISEASE 727 5.38e-02 4.22e-02 4.24e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 8.00e-01 -4.22e-02 9.54e-01
LDL CLEARANCE 16 7.72e-01 4.18e-02 9.48e-01
MEMBRANE TRAFFICKING 579 8.77e-02 -4.17e-02 4.84e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 108 4.54e-01 4.17e-02 8.10e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 7.41e-01 -4.17e-02 9.36e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 7.95e-01 -4.16e-02 9.53e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 6.71e-01 4.15e-02 9.12e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 5.95e-01 -4.15e-02 8.86e-01
TCR SIGNALING 102 4.70e-01 4.15e-02 8.21e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 3.42e-01 4.14e-02 7.48e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 7.05e-01 4.14e-02 9.22e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 6.72e-01 -4.13e-02 9.12e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 7.10e-01 -4.06e-02 9.24e-01
RHOH GTPASE CYCLE 37 6.69e-01 -4.06e-02 9.12e-01
G ALPHA S SIGNALLING EVENTS 103 4.79e-01 -4.04e-02 8.28e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 7.80e-01 4.03e-02 9.50e-01
RAC2 GTPASE CYCLE 86 5.21e-01 4.01e-02 8.60e-01
CELL CYCLE CHECKPOINTS 241 2.85e-01 -4.01e-02 7.03e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 6.31e-01 -4.00e-02 9.00e-01
INFLAMMASOMES 19 7.64e-01 -3.99e-02 9.45e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 6.88e-01 -3.98e-02 9.17e-01
SIGNALING BY ERBB4 57 6.04e-01 -3.97e-02 8.89e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 6.38e-01 3.96e-02 9.01e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 8.05e-01 -3.96e-02 9.55e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 5.28e-01 -3.94e-02 8.61e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 8.13e-01 3.94e-02 9.58e-01
SIGNALING BY NOTCH4 83 5.37e-01 3.92e-02 8.66e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 5.14e-01 -3.91e-02 8.55e-01
DNA DOUBLE STRAND BREAK REPAIR 136 4.32e-01 -3.91e-02 7.94e-01
EPH EPHRIN SIGNALING 90 5.22e-01 -3.90e-02 8.60e-01
SENSORY PERCEPTION 146 4.16e-01 3.90e-02 7.93e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 8.32e-01 -3.88e-02 9.68e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 183 3.70e-01 -3.85e-02 7.67e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 226 3.20e-01 3.84e-02 7.40e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 7.87e-01 3.79e-02 9.52e-01
REGULATION OF SIGNALING BY CBL 22 7.62e-01 3.73e-02 9.45e-01
RHOF GTPASE CYCLE 40 6.84e-01 -3.72e-02 9.15e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 5.66e-01 3.69e-02 8.79e-01
RHO GTPASES ACTIVATE FORMINS 118 4.92e-01 3.67e-02 8.40e-01
PD 1 SIGNALING 10 8.42e-01 3.64e-02 9.69e-01
HYALURONAN METABOLISM 15 8.08e-01 -3.62e-02 9.56e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 8.21e-01 -3.62e-02 9.63e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 17 7.97e-01 -3.61e-02 9.53e-01
DNA REPLICATION PRE INITIATION 79 5.83e-01 -3.58e-02 8.80e-01
SIGNALING BY NOTCH1 75 5.93e-01 3.57e-02 8.85e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 7.33e-01 -3.54e-02 9.33e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 7.18e-01 -3.53e-02 9.24e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 7.56e-01 -3.52e-02 9.43e-01
REPRODUCTION 75 6.01e-01 3.49e-02 8.89e-01
ION CHANNEL TRANSPORT 138 4.81e-01 -3.48e-02 8.30e-01
MAPK FAMILY SIGNALING CASCADES 288 3.12e-01 3.47e-02 7.33e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 7.35e-01 3.45e-02 9.35e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 7.80e-01 -3.45e-02 9.50e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 76 6.05e-01 -3.43e-02 8.89e-01
REGULATION OF BETA CELL DEVELOPMENT 24 7.71e-01 -3.43e-02 9.48e-01
NEUREXINS AND NEUROLIGINS 54 6.64e-01 3.42e-02 9.12e-01
HATS ACETYLATE HISTONES 91 5.74e-01 -3.41e-02 8.80e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 6.71e-01 -3.40e-02 9.12e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 6.94e-01 -3.39e-02 9.18e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 8.33e-01 3.38e-02 9.68e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 10 8.55e-01 3.35e-02 9.73e-01
FCERI MEDIATED MAPK ACTIVATION 28 7.59e-01 -3.34e-02 9.45e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 7.82e-01 3.34e-02 9.50e-01
FRS MEDIATED FGFR2 SIGNALING 18 8.07e-01 3.33e-02 9.56e-01
SIGNALING BY NOTCH 188 4.34e-01 3.31e-02 7.95e-01
EFFECTS OF PIP2 HYDROLYSIS 27 7.66e-01 3.31e-02 9.45e-01
NUCLEOTIDE EXCISION REPAIR 109 5.55e-01 -3.28e-02 8.73e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 6.80e-01 3.28e-02 9.13e-01
EXTENSION OF TELOMERES 50 6.91e-01 3.26e-02 9.17e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 6.56e-01 -3.25e-02 9.12e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 42 7.18e-01 -3.22e-02 9.24e-01
G PROTEIN ACTIVATION 22 7.96e-01 -3.19e-02 9.53e-01
TBC RABGAPS 43 7.18e-01 -3.19e-02 9.24e-01
SPRY REGULATION OF FGF SIGNALING 16 8.29e-01 -3.11e-02 9.68e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 6.26e-01 -3.10e-02 8.97e-01
FRS MEDIATED FGFR1 SIGNALING 17 8.26e-01 3.09e-02 9.67e-01
SIGNALING BY INTERLEUKINS 348 3.26e-01 3.07e-02 7.42e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 7.68e-01 -3.06e-02 9.45e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.49e-01 3.05e-02 9.72e-01
PROLACTIN RECEPTOR SIGNALING 11 8.61e-01 -3.05e-02 9.73e-01
DNA METHYLATION 20 8.13e-01 3.05e-02 9.58e-01
GLYCOSPHINGOLIPID METABOLISM 38 7.47e-01 -3.02e-02 9.40e-01
NUCLEOBASE CATABOLISM 31 7.72e-01 -3.01e-02 9.48e-01
SYNTHESIS OF PE 12 8.57e-01 -3.00e-02 9.73e-01
INTERACTION BETWEEN L1 AND ANKYRINS 29 7.80e-01 3.00e-02 9.50e-01
TOLL LIKE RECEPTOR CASCADES 137 5.47e-01 -2.98e-02 8.71e-01
CIRCADIAN CLOCK 68 6.76e-01 -2.94e-02 9.13e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 8.12e-01 -2.92e-02 9.58e-01
VESICLE MEDIATED TRANSPORT 608 2.25e-01 -2.90e-02 6.69e-01
INTERLEUKIN 12 FAMILY SIGNALING 44 7.40e-01 2.89e-02 9.35e-01
CLEC7A DECTIN 1 SIGNALING 94 6.30e-01 2.88e-02 9.00e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 15 8.47e-01 -2.87e-02 9.72e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 110 6.05e-01 -2.86e-02 8.89e-01
METABOLISM OF VITAMINS AND COFACTORS 150 5.50e-01 2.83e-02 8.71e-01
DEFECTS IN COBALAMIN B12 METABOLISM 12 8.65e-01 2.83e-02 9.73e-01
SIGNALING BY FGFR IN DISEASE 55 7.17e-01 2.83e-02 9.24e-01
LEISHMANIA INFECTION 193 5.02e-01 -2.81e-02 8.49e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 7.98e-01 2.80e-02 9.53e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 8.57e-01 2.78e-02 9.73e-01
M PHASE 337 3.83e-01 2.77e-02 7.74e-01
OXIDATIVE STRESS INDUCED SENESCENCE 78 6.72e-01 2.77e-02 9.12e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 8.64e-01 2.74e-02 9.73e-01
SIGNALING BY FGFR4 31 7.93e-01 2.73e-02 9.53e-01
TRNA PROCESSING 105 6.30e-01 2.72e-02 9.00e-01
TRP CHANNELS 19 8.37e-01 -2.72e-02 9.69e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.82e-01 2.71e-02 9.77e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 7.49e-01 2.67e-02 9.40e-01
RA BIOSYNTHESIS PATHWAY 13 8.68e-01 -2.67e-02 9.73e-01
SARS COV INFECTIONS 139 5.90e-01 2.65e-02 8.83e-01
MAP2K AND MAPK ACTIVATION 36 7.85e-01 2.63e-02 9.52e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 8.27e-01 2.63e-02 9.68e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 8.04e-01 2.62e-02 9.55e-01
FRS MEDIATED FGFR4 SIGNALING 12 8.75e-01 2.62e-02 9.77e-01
DISEASES OF GLYCOSYLATION 125 6.14e-01 2.62e-02 8.93e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 8.35e-01 -2.56e-02 9.68e-01
REGULATION OF TP53 ACTIVITY 148 5.92e-01 2.56e-02 8.84e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.89e-01 2.55e-02 9.77e-01
CELLULAR RESPONSE TO HEAT STRESS 95 6.70e-01 2.53e-02 9.12e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 8.33e-01 -2.49e-02 9.68e-01
MTOR SIGNALLING 40 7.86e-01 -2.48e-02 9.52e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 7.32e-01 -2.47e-02 9.33e-01
HIV TRANSCRIPTION INITIATION 45 7.74e-01 -2.47e-02 9.48e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 8.38e-01 -2.47e-02 9.69e-01
NEUTROPHIL DEGRANULATION 383 4.17e-01 2.42e-02 7.93e-01
CHROMOSOME MAINTENANCE 103 6.71e-01 2.42e-02 9.12e-01
FATTY ACID METABOLISM 146 6.14e-01 2.42e-02 8.93e-01
RAC3 GTPASE CYCLE 88 6.95e-01 -2.42e-02 9.19e-01
HEMOSTASIS 472 3.71e-01 2.41e-02 7.67e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 8.81e-01 -2.41e-02 9.77e-01
IRAK4 DEFICIENCY TLR2 4 12 8.87e-01 2.38e-02 9.77e-01
AQUAPORIN MEDIATED TRANSPORT 40 7.95e-01 -2.37e-02 9.53e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 8.51e-01 -2.36e-02 9.72e-01
ACYL CHAIN REMODELLING OF PC 17 8.67e-01 2.35e-02 9.73e-01
RECEPTOR MEDIATED MITOPHAGY 11 8.94e-01 2.32e-02 9.77e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 7.54e-01 -2.32e-02 9.42e-01
HIV LIFE CYCLE 143 6.38e-01 2.28e-02 9.01e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 8.82e-01 2.28e-02 9.77e-01
ION TRANSPORT BY P TYPE ATPASES 47 7.89e-01 -2.25e-02 9.53e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 8.88e-01 -2.25e-02 9.77e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 8.40e-01 2.24e-02 9.69e-01
TRANSLESION SYNTHESIS BY POLH 19 8.66e-01 2.23e-02 9.73e-01
NEUROTRANSMITTER RELEASE CYCLE 48 7.89e-01 2.23e-02 9.53e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 100 7.01e-01 2.22e-02 9.22e-01
INTERLEUKIN 6 SIGNALING 10 9.03e-01 -2.22e-02 9.77e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 7.61e-01 -2.22e-02 9.45e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 184 6.05e-01 -2.21e-02 8.89e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 8.21e-01 2.21e-02 9.63e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 7.30e-01 2.18e-02 9.32e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 8.36e-01 -2.15e-02 9.68e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 8.78e-01 2.15e-02 9.77e-01
AMYLOID FIBER FORMATION 57 7.81e-01 -2.13e-02 9.50e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 81 7.43e-01 2.11e-02 9.38e-01
GAB1 SIGNALOSOME 14 8.92e-01 2.10e-02 9.77e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 7.53e-01 -2.09e-02 9.42e-01
ONCOGENE INDUCED SENESCENCE 32 8.39e-01 -2.08e-02 9.69e-01
C TYPE LECTIN RECEPTORS CLRS 112 7.04e-01 2.08e-02 9.22e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 7.81e-01 -2.07e-02 9.50e-01
SURFACTANT METABOLISM 16 8.87e-01 2.06e-02 9.77e-01
G0 AND EARLY G1 24 8.63e-01 -2.04e-02 9.73e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 8.57e-01 2.04e-02 9.73e-01
PEPTIDE LIGAND BINDING RECEPTORS 103 7.25e-01 -2.01e-02 9.28e-01
PECAM1 INTERACTIONS 12 9.07e-01 1.94e-02 9.77e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 8.46e-01 -1.93e-02 9.72e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 9.08e-01 -1.92e-02 9.77e-01
MEIOSIS 63 7.93e-01 -1.91e-02 9.53e-01
INTERLEUKIN 12 SIGNALING 37 8.41e-01 -1.90e-02 9.69e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 14 9.02e-01 1.90e-02 9.77e-01
METABOLISM OF LIPIDS 611 4.28e-01 -1.89e-02 7.94e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.82e-01 1.88e-02 9.77e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 7.21e-01 -1.87e-02 9.26e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 9.07e-01 -1.86e-02 9.77e-01
MITOTIC SPINDLE CHECKPOINT 96 7.53e-01 -1.86e-02 9.42e-01
REGULATED NECROSIS 45 8.31e-01 -1.84e-02 9.68e-01
PKMTS METHYLATE HISTONE LYSINES 48 8.26e-01 1.83e-02 9.67e-01
PERK REGULATES GENE EXPRESSION 28 8.67e-01 -1.82e-02 9.73e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 8.88e-01 -1.82e-02 9.77e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 9.00e-01 1.81e-02 9.77e-01
VIRAL MESSENGER RNA SYNTHESIS 42 8.40e-01 -1.80e-02 9.69e-01
METABOLISM OF CARBOHYDRATES 258 6.20e-01 -1.80e-02 8.93e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 8.58e-01 1.79e-02 9.73e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 9.11e-01 -1.79e-02 9.78e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 8.88e-01 1.77e-02 9.77e-01
INTEGRATION OF ENERGY METABOLISM 98 7.67e-01 1.73e-02 9.45e-01
TRANSLESION SYNTHESIS BY POLK 17 9.02e-01 -1.73e-02 9.77e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 8.54e-01 -1.73e-02 9.73e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 8.18e-01 -1.70e-02 9.62e-01
MISMATCH REPAIR 14 9.13e-01 1.69e-02 9.79e-01
HS GAG DEGRADATION 20 8.97e-01 -1.68e-02 9.77e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 85 7.97e-01 -1.61e-02 9.53e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 8.85e-01 -1.60e-02 9.77e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 8.81e-01 -1.60e-02 9.77e-01
METABOLISM OF FAT SOLUBLE VITAMINS 33 8.77e-01 1.56e-02 9.77e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 21 9.04e-01 1.52e-02 9.77e-01
ESTROGEN DEPENDENT GENE EXPRESSION 100 7.99e-01 -1.48e-02 9.53e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 8.94e-01 1.43e-02 9.77e-01
INNATE IMMUNE SYSTEM 772 5.07e-01 1.41e-02 8.51e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 8.35e-01 1.40e-02 9.68e-01
KERATAN SULFATE BIOSYNTHESIS 24 9.08e-01 -1.37e-02 9.77e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 8.89e-01 -1.36e-02 9.77e-01
DEUBIQUITINATION 241 7.18e-01 -1.35e-02 9.24e-01
SIGNAL TRANSDUCTION BY L1 21 9.15e-01 1.34e-02 9.80e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 8.53e-01 1.32e-02 9.73e-01
GOLGI TO ER RETROGRADE TRANSPORT 118 8.05e-01 -1.32e-02 9.55e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 9.02e-01 -1.32e-02 9.77e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 9.40e-01 1.31e-02 9.84e-01
SIGNALING BY FGFR2 IN DISEASE 36 8.93e-01 1.30e-02 9.77e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 114 8.11e-01 -1.30e-02 9.57e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 8.63e-01 1.30e-02 9.73e-01
SPHINGOLIPID METABOLISM 79 8.46e-01 -1.27e-02 9.72e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 9.35e-01 -1.25e-02 9.83e-01
TRAFFICKING OF AMPA RECEPTORS 31 9.04e-01 1.25e-02 9.77e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 9.43e-01 1.25e-02 9.84e-01
TIE2 SIGNALING 17 9.29e-01 1.25e-02 9.83e-01
SIGNALING BY VEGF 102 8.30e-01 1.23e-02 9.68e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.25e-01 -1.22e-02 9.83e-01
GENE SILENCING BY RNA 84 8.50e-01 -1.20e-02 9.72e-01
REGULATION OF INSULIN SECRETION 71 8.62e-01 -1.20e-02 9.73e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 9.23e-01 1.19e-02 9.83e-01
TRNA PROCESSING IN THE NUCLEUS 56 8.80e-01 -1.16e-02 9.77e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 8.60e-01 -1.16e-02 9.73e-01
MUSCLE CONTRACTION 163 8.01e-01 1.15e-02 9.54e-01
SIGNALING BY ERBB2 48 8.91e-01 -1.14e-02 9.77e-01
RND3 GTPASE CYCLE 38 9.03e-01 -1.14e-02 9.77e-01
RHOJ GTPASE CYCLE 54 8.89e-01 1.10e-02 9.77e-01
PROTEIN LOCALIZATION 156 8.14e-01 -1.09e-02 9.58e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 8.50e-01 -1.08e-02 9.72e-01
SIGNALING BY EGFR 47 8.98e-01 1.08e-02 9.77e-01
DUAL INCISION IN TC NER 64 8.83e-01 -1.07e-02 9.77e-01
SNRNP ASSEMBLY 51 8.97e-01 -1.05e-02 9.77e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 9.30e-01 -1.04e-02 9.83e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 464 7.03e-01 1.04e-02 9.22e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 9.38e-01 1.03e-02 9.84e-01
RHOD GTPASE CYCLE 50 9.04e-01 9.81e-03 9.77e-01
MRNA CAPPING 29 9.29e-01 9.62e-03 9.83e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 8.84e-01 9.58e-03 9.77e-01
CALNEXIN CALRETICULIN CYCLE 26 9.33e-01 9.55e-03 9.83e-01
CELL CYCLE MITOTIC 471 7.24e-01 9.54e-03 9.27e-01
P38MAPK EVENTS 13 9.53e-01 9.47e-03 9.84e-01
TRANSCRIPTIONAL REGULATION BY TP53 338 7.67e-01 -9.41e-03 9.45e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 140 8.51e-01 -9.23e-03 9.72e-01
ERYTHROPOIETIN ACTIVATES RAS 13 9.55e-01 9.04e-03 9.84e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 52 9.11e-01 8.97e-03 9.78e-01
ONCOGENIC MAPK SIGNALING 77 8.93e-01 -8.86e-03 9.77e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.29e-01 -8.80e-03 9.83e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 366 7.78e-01 -8.59e-03 9.50e-01
SIGNALING BY NOTCH3 48 9.19e-01 8.50e-03 9.82e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 9.44e-01 8.10e-03 9.84e-01
ASPARTATE AND ASPARAGINE METABOLISM 10 9.65e-01 8.05e-03 9.87e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 9.55e-01 -7.68e-03 9.84e-01
GLUCOSE METABOLISM 80 9.06e-01 7.61e-03 9.77e-01
SIGNALING BY FGFR1 IN DISEASE 32 9.41e-01 7.53e-03 9.84e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 9.36e-01 7.22e-03 9.83e-01
HIV INFECTION 221 8.59e-01 6.93e-03 9.73e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 9.33e-01 6.79e-03 9.83e-01
PRE NOTCH EXPRESSION AND PROCESSING 63 9.27e-01 6.66e-03 9.83e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 9.70e-01 6.66e-03 9.87e-01
DNA DAMAGE RECOGNITION IN GG NER 38 9.44e-01 6.64e-03 9.84e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.56e-01 -6.60e-03 9.84e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 9.55e-01 6.41e-03 9.84e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 9.67e-01 6.18e-03 9.87e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 9.20e-01 -6.09e-03 9.82e-01
GLYCOLYSIS 66 9.34e-01 -5.90e-03 9.83e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 9.61e-01 -5.89e-03 9.85e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 35 9.52e-01 5.83e-03 9.84e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 9.26e-01 -5.73e-03 9.83e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 9.45e-01 5.72e-03 9.84e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 9.70e-01 -5.68e-03 9.87e-01
MHC CLASS II ANTIGEN PRESENTATION 103 9.21e-01 5.66e-03 9.82e-01
FLT3 SIGNALING IN DISEASE 27 9.61e-01 -5.51e-03 9.85e-01
RND2 GTPASE CYCLE 38 9.54e-01 5.45e-03 9.84e-01
SIGNALING BY FGFR1 43 9.51e-01 -5.41e-03 9.84e-01
RET SIGNALING 37 9.56e-01 -5.24e-03 9.84e-01
CELLULAR SENESCENCE 140 9.16e-01 5.17e-03 9.80e-01
PHASE II CONJUGATION OF COMPOUNDS 60 9.45e-01 5.11e-03 9.84e-01
HOST INTERACTIONS OF HIV FACTORS 125 9.24e-01 -4.94e-03 9.83e-01
UB SPECIFIC PROCESSING PROTEASES 167 9.14e-01 -4.87e-03 9.79e-01
RHO GTPASES ACTIVATE PKNS 47 9.54e-01 -4.84e-03 9.84e-01
ORC1 REMOVAL FROM CHROMATIN 67 9.46e-01 -4.80e-03 9.84e-01
KERATAN SULFATE KERATIN METABOLISM 30 9.64e-01 4.74e-03 9.87e-01
RUNX3 REGULATES NOTCH SIGNALING 13 9.77e-01 4.62e-03 9.91e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 9.68e-01 -4.49e-03 9.87e-01
METABOLISM OF STEROIDS 112 9.35e-01 4.47e-03 9.83e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 9.60e-01 -4.46e-03 9.85e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 282 9.01e-01 4.32e-03 9.77e-01
TELOMERE MAINTENANCE 79 9.48e-01 4.25e-03 9.84e-01
AMINO ACIDS REGULATE MTORC1 51 9.58e-01 -4.25e-03 9.85e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 9.49e-01 4.23e-03 9.84e-01
SIGNALING BY NODAL 15 9.79e-01 3.94e-03 9.91e-01
APOPTOSIS 162 9.34e-01 3.79e-03 9.83e-01
RORA ACTIVATES GENE EXPRESSION 18 9.78e-01 -3.73e-03 9.91e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 9.68e-01 3.67e-03 9.87e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 9.77e-01 -3.65e-03 9.91e-01
PHOSPHOLIPID METABOLISM 186 9.32e-01 -3.61e-03 9.83e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 138 9.43e-01 3.52e-03 9.84e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 9.86e-01 -3.25e-03 9.94e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 17 9.82e-01 3.22e-03 9.92e-01
METABOLISM OF STEROID HORMONES 20 9.80e-01 3.20e-03 9.91e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 9.76e-01 -2.70e-03 9.91e-01
SIGNALING BY EGFR IN CANCER 22 9.85e-01 2.29e-03 9.94e-01
PROTEIN METHYLATION 17 9.88e-01 -2.12e-03 9.94e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 62 9.79e-01 1.97e-03 9.91e-01
SIGNALING BY WNT 266 9.60e-01 -1.77e-03 9.85e-01
PURINE SALVAGE 12 9.92e-01 -1.64e-03 9.96e-01
CELL CYCLE 589 9.47e-01 1.59e-03 9.84e-01
PROGRAMMED CELL DEATH 184 9.71e-01 -1.54e-03 9.88e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 9.88e-01 1.51e-03 9.94e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 9.90e-01 -1.44e-03 9.96e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 9.87e-01 -1.39e-03 9.94e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 9.93e-01 1.26e-03 9.96e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 27 9.92e-01 1.06e-03 9.96e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 9.96e-01 5.64e-04 9.97e-01
G ALPHA Q SIGNALLING EVENTS 156 9.96e-01 -2.31e-04 9.97e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.00e+00 -1.55e-05 1.00e+00


Detailed Gene set reports



MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
534
set MET ACTIVATES RAP1 AND RAC1
setSize 11
pANOVA 0.00104
s.dist -0.571
p.adjustANOVA 0.0296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rap1b -8382
Met -7793
Hgf -7787
Rac1 -7094
Dock7 -6822
Crkl -5515
Rap1a -5254
Crk -5197
Gab1 -4850
Grb2 -3233
Rapgef1 4681

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rap1b -8382
Met -7793
Hgf -7787
Rac1 -7094
Dock7 -6822
Crkl -5515
Rap1a -5254
Crk -5197
Gab1 -4850
Grb2 -3233
Rapgef1 4681


SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
1039
set SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
setSize 11
pANOVA 0.00215
s.dist -0.534
p.adjustANOVA 0.0511



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7642
Pik3c3 -6280
Mtmr9 -5965
Mtmr7 -5768
Mtmr4 -5613
Fig4 -4289
Pik3r4 -3300
Mtm1 393
Vac14 638

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7642
Pik3c3 -6280
Mtmr9 -5965
Mtmr7 -5768
Mtmr4 -5613
Fig4 -4289
Pik3r4 -3300
Mtm1 393
Vac14 638


ACTIVATION OF RAC1

ACTIVATION OF RAC1
24
set ACTIVATION OF RAC1
setSize 13
pANOVA 0.00176
s.dist -0.501
p.adjustANOVA 0.0448



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slit2 -8763
Pak1 -7266
Robo1 -7152
Rac1 -7094
Sos2 -6283
Sos1 -5957
Pak5 -5255
Pak3 -3689
Pak6 -2724
Pak2 -2269
Pak4 -1910
Nck2 -1100
Nck1 -530

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slit2 -8763
Pak1 -7266
Robo1 -7152
Rac1 -7094
Sos2 -6283
Sos1 -5957
Pak5 -5255
Pak3 -3689
Pak6 -2724
Pak2 -2269
Pak4 -1910
Nck2 -1100
Nck1 -530


INITIAL TRIGGERING OF COMPLEMENT

INITIAL TRIGGERING OF COMPLEMENT
443
set INITIAL TRIGGERING OF COMPLEMENT
setSize 10
pANOVA 0.01
s.dist 0.47
p.adjustANOVA 0.154



Top enriched genes

Top 20 genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6966
Masp2 5994
C4b 4905
C1qc 4382
C1qa 3001
Masp1 2826
Gzmm -547
Cfb -7716

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6966
Masp2 5994
C4b 4905
C1qc 4382
C1qa 3001
Masp1 2826
Gzmm -547
Cfb -7716


CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
199
set CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
setSize 13
pANOVA 0.00633
s.dist 0.437
p.adjustANOVA 0.115



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ercc2 7653
Ciao2b 7479
Ndor1 7409
Pold1 6726
Ciapin1 5074
Ciao3 5063
Rtel1 4820
Brip1 4238
Nubp1 3460
Abcb7 -1266
Mms19 -1589
Nubp2 -3102
Ciao1 -3545

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ercc2 7653
Ciao2b 7479
Ndor1 7409
Pold1 6726
Ciapin1 5074
Ciao3 5063
Rtel1 4820
Brip1 4238
Nubp1 3460
Abcb7 -1266
Mms19 -1589
Nubp2 -3102
Ciao1 -3545


EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
301
set EUKARYOTIC TRANSLATION ELONGATION
setSize 87
pANOVA 1.86e-12
s.dist 0.437
p.adjustANOVA 2.18e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps28 7597
Rps8 7450
Rpl26 7359
Rpl28 7124
Eef1d 6824
Rpl38 6634
Rplp2 6619
Rps29 6609
Eef1a2 6277
Rpl35 6264
Eef2 6157
Rpl23a 6154
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps28 7597
Rps8 7450
Rpl26 7359
Rpl28 7124
Eef1d 6824
Rpl38 6634
Rplp2 6619
Rps29 6609
Eef1a2 6277
Rpl35 6264
Eef2 6157
Rpl23a 6154
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531
Rpl37 5530
Rps19 5400
Rpl6 5381
Rps18 5259
Rpl8 5182
Rps27l 4781
Rpl35a 4749
Eef1g 4670
Rplp1 4497
Rpl7a 4489
Rpl24 4485
Rps25 4349
Rps3a1 4211
Rpl14 4027
Rpl32 4021
Rpl13 3983
Rps17 3940
Rps11 3934
Rpl18a 3929
Uba52 3876
Rpl12 3790
Rpl10 3755
Rps6 3747
Fau 3714
Rpl30 3435
Rps16 3425
Rpl31 3267
Rps14 3149
Rps24 3077
Rps15 3027
Rpl21 3024
Rps10 2979
Rpl27a 2892
Eef1b2 2808
Rpl36al 2751
Rps7 2731
Rpl19 2668
Rpl3 2654
Rpsa 2614
Rpl36 2443
Rpl11 2320
Rps5 2249
Rpl18 1869
Rps27 1669
Rpl9 1493
Rpl5 1297
Rps12 1217
Rpl36a 927
Rpl10a 895
Rpl4 873
Rps23 872
Rpl22 732
Rpl27 529
Rpl13a 406
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Rpl7 -1359
Rps15a -1947
Rpl39 -2430
Rpl17 -2699
Eef1a1 -2849
Rpl15 -3330
Rpl22l1 -3372


CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
185
set CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
setSize 11
pANOVA 0.0122
s.dist -0.437
p.adjustANOVA 0.171



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prkacb -8544
Prkar2b -8346
Prkar1a -7991
Creb1 -7647
Prkx -7158
Calm1 -6803
Adcy1 -4571
Prkar1b -546
Adcy8 661
Prkaca 1782
Prkar2a 4341

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prkacb -8544
Prkar2b -8346
Prkar1a -7991
Creb1 -7647
Prkx -7158
Calm1 -6803
Adcy1 -4571
Prkar1b -546
Adcy8 661
Prkaca 1782
Prkar2a 4341


NF KB IS ACTIVATED AND SIGNALS SURVIVAL

NF KB IS ACTIVATED AND SIGNALS SURVIVAL
621
set NF KB IS ACTIVATED AND SIGNALS SURVIVAL
setSize 13
pANOVA 0.00681
s.dist 0.433
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ikbkb 6593
Nfkb1 6575
Irak1 6335
Rps27a 5852
Ngfr 5541
Uba52 3876
Ubc 3089
Ubb 2615
Ngf 2468
Nfkbia 2118
Sqstm1 727
Rela 29
Traf6 -3825

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ikbkb 6593
Nfkb1 6575
Irak1 6335
Rps27a 5852
Ngfr 5541
Uba52 3876
Ubc 3089
Ubb 2615
Ngf 2468
Nfkbia 2118
Sqstm1 727
Rela 29
Traf6 -3825


ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON

ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
20
set ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON
setSize 16
pANOVA 0.00278
s.dist 0.432
p.adjustANOVA 0.0636



Top enriched genes

Top 20 genes
GeneID Gene Rank
Irf3 7213
Ticam2 6835
Cd14 6545
Rps27a 5852
Ikbke 4960
Ptpn11 4357
Ticam1 4298
Tlr4 3893
Uba52 3876
Traf3 3513
Ubc 3089
Tank 2755
Ubb 2615
Tbk1 643
Sarm1 -166
Irf7 -8811

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf3 7213
Ticam2 6835
Cd14 6545
Rps27a 5852
Ikbke 4960
Ptpn11 4357
Ticam1 4298
Tlr4 3893
Uba52 3876
Traf3 3513
Ubc 3089
Tank 2755
Ubb 2615
Tbk1 643
Sarm1 -166
Irf7 -8811


SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE

SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE
909
set SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE
setSize 20
pANOVA 0.000909
s.dist 0.428
p.adjustANOVA 0.0265



Top enriched genes

Top 20 genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7493
Limk2 7421
Plxnb1 6902
Limk1 6628
Myh9 6341
Rhoc 5770
Rnd1 5407
Myl6 4895
Myl12b 4330
Myh10 3504
Arhgef11 2057
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2059
Rhoa -3484
Rhob -5010

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7493
Limk2 7421
Plxnb1 6902
Limk1 6628
Myh9 6341
Rhoc 5770
Rnd1 5407
Myl6 4895
Myl12b 4330
Myh10 3504
Arhgef11 2057
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2059
Rhoa -3484
Rhob -5010


SCAVENGING BY CLASS A RECEPTORS

SCAVENGING BY CLASS A RECEPTORS
901
set SCAVENGING BY CLASS A RECEPTORS
setSize 14
pANOVA 0.00755
s.dist 0.412
p.adjustANOVA 0.131



Top enriched genes

Top 20 genes
GeneID Gene Rank
Calr 7889
Col1a2 7492
Colec12 7328
Apoe 6023
Col3a1 5984
Col4a2 5670
Masp1 2826
Col1a1 2599
Hsp90b1 2547
Ftl1 1744
Apoa1 -74
Fth1 -278
Col4a1 -844
Scara5 -6165

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calr 7889
Col1a2 7492
Colec12 7328
Apoe 6023
Col3a1 5984
Col4a2 5670
Masp1 2826
Col1a1 2599
Hsp90b1 2547
Ftl1 1744
Apoa1 -74
Fth1 -278
Col4a1 -844
Scara5 -6165


SEROTONIN RECEPTORS

SEROTONIN RECEPTORS
917
set SEROTONIN RECEPTORS
setSize 10
pANOVA 0.0292
s.dist -0.398
p.adjustANOVA 0.296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Htr4 -8729
Htr5a -7227
Htr2a -7180
Htr2c -6735
Htr1d -5086
Htr6 -2887
Htr1f -2717
Htr1a 57
Htr1b 1192
Htr7 1775

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Htr4 -8729
Htr5a -7227
Htr2a -7180
Htr2c -6735
Htr1d -5086
Htr6 -2887
Htr1f -2717
Htr1a 57
Htr1b 1192
Htr7 1775


COLLAGEN CHAIN TRIMERIZATION

COLLAGEN CHAIN TRIMERIZATION
164
set COLLAGEN CHAIN TRIMERIZATION
setSize 40
pANOVA 1.46e-05
s.dist 0.396
p.adjustANOVA 0.000812



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7492
Col16a1 7367
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Col6a2 6291
Col3a1 5984
Col6a1 5959
Col4a2 5670
Col28a1 4763
Col6a3 4621
Col15a1 4606
Col9a3 3789

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7492
Col16a1 7367
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Col6a2 6291
Col3a1 5984
Col6a1 5959
Col4a2 5670
Col28a1 4763
Col6a3 4621
Col15a1 4606
Col9a3 3789
Col18a1 3050
Col24a1 2997
Col1a1 2599
Col4a5 2486
Col17a1 2390
Col6a5 2356
Col20a1 1863
Col4a3 1850
Col11a1 1221
Col14a1 -449
Col19a1 -590
Col8a1 -758
Col4a1 -844
Col5a1 -939
Col23a1 -3675
Col9a1 -4500
Col6a6 -5128
Col25a1 -5179
Col22a1 -5346
Col8a2 -7555


SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
1037
set SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
setSize 16
pANOVA 0.00615
s.dist -0.396
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7642
Pik3c3 -6280
Mtmr12 -5786
Mtmr4 -5613
Fig4 -4289
Inpp5f -4102
Inpp4a -3940
Pi4k2b -3897
Pik3r4 -3300
Mtmr10 -1072
Mtm1 393
Inpp4b 582
Vac14 638
Pi4k2a 669

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pikfyve -8077
Pik3c2a -7961
Mtmr2 -7642
Pik3c3 -6280
Mtmr12 -5786
Mtmr4 -5613
Fig4 -4289
Inpp5f -4102
Inpp4a -3940
Pi4k2b -3897
Pik3r4 -3300
Mtmr10 -1072
Mtm1 393
Inpp4b 582
Vac14 638
Pi4k2a 669


REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA

REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA
798
set REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA
setSize 13
pANOVA 0.0189
s.dist 0.376
p.adjustANOVA 0.227



Top enriched genes

Top 20 genes
GeneID Gene Rank
Irf3 7213
Rps27a 5852
Sting1 5286
Ddx41 4210
Uba52 3876
Dtx4 3119
Ubc 3089
Ubb 2615
Trim56 1619
Tbk1 643
Trim32 -53
Trex1 -238
Trim21 -1495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf3 7213
Rps27a 5852
Sting1 5286
Ddx41 4210
Uba52 3876
Dtx4 3119
Ubc 3089
Ubb 2615
Trim56 1619
Tbk1 643
Trim32 -53
Trex1 -238
Trim21 -1495


RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
833
set RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize 94
pANOVA 3.75e-10
s.dist 0.374
p.adjustANOVA 7.95e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ddit3 7639
Rps28 7597
Rps8 7450
Rpl26 7359
Rpl28 7124
Rpl38 6634
Rplp2 6619
Rps29 6609
Rpl35 6264
Gcn1 6172
Rpl23a 6154
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ddit3 7639
Rps28 7597
Rps8 7450
Rpl26 7359
Rpl28 7124
Rpl38 6634
Rplp2 6619
Rps29 6609
Rpl35 6264
Gcn1 6172
Rpl23a 6154
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531
Rpl37 5530
Rps19 5400
Rpl6 5381
Rps18 5259
Rpl8 5182
Rps27l 4781
Rpl35a 4749
Rplp1 4497
Rpl7a 4489
Rpl24 4485
Rps25 4349
Rps3a1 4211
Rpl14 4027
Rpl32 4021
Rpl13 3983
Rps17 3940
Rps11 3934
Rpl18a 3929
Uba52 3876
Atf4 3827
Rpl12 3790
Rpl10 3755
Rps6 3747
Fau 3714
Rpl30 3435
Rps16 3425
Rpl31 3267
Rps14 3149
Rps24 3077
Rps15 3027
Rpl21 3024
Rps10 2979
Rpl27a 2892
Rpl36al 2751
Rps7 2731
Rpl19 2668
Rpl3 2654
Atf3 2633
Rpsa 2614
Rpl36 2443
Rpl11 2320
Rps5 2249
Rpl18 1869
Rps27 1669
Rpl9 1493
Rpl5 1297
Rps12 1217
Rpl36a 927
Rpl10a 895
Impact 879
Rpl4 873
Rps23 872
Eif2ak4 840
Rpl22 732
Rpl27 529
Rpl13a 406
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Eif2s1 -1087
Rpl7 -1359
Eif2s2 -1396
Cebpg -1746
Eif2s3x -1929
Rps15a -1947
Rpl39 -2430
Rpl17 -2699
Rpl15 -3330
Rpl22l1 -3372
Cebpb -4230
Asns -6276
Atf2 -8357


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
45
set ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize 12
pANOVA 0.0277
s.dist 0.367
p.adjustANOVA 0.292



Top enriched genes

Top 20 genes
GeneID Gene Rank
Elovl1 7986
Acaa1a 6080
Acot8 5801
Abcd1 5702
Fads1 5189
Hsd17b4 4959
Fads2 4816
Scp2 1613
Elovl5 404
Elovl2 -903
Acsl1 -4238
Acox1 -5344

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elovl1 7986
Acaa1a 6080
Acot8 5801
Abcd1 5702
Fads1 5189
Hsd17b4 4959
Fads2 4816
Scp2 1613
Elovl5 404
Elovl2 -903
Acsl1 -4238
Acox1 -5344


COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
163
set COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
setSize 63
pANOVA 9.65e-07
s.dist 0.357
p.adjustANOVA 7.04e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col13a1 7899
Bmp1 7814
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
P4ha2 7608
Col1a2 7492
Col16a1 7367
Plod3 7307
P3h3 7256
Colgalt1 7126
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Serpinh1 6688
Col6a2 6291
Col3a1 5984

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col13a1 7899
Bmp1 7814
Col26a1 7772
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
P4ha2 7608
Col1a2 7492
Col16a1 7367
Plod3 7307
P3h3 7256
Colgalt1 7126
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Serpinh1 6688
Col6a2 6291
Col3a1 5984
Col6a1 5959
P4ha3 5888
Col4a2 5670
P3h1 5214
P4ha1 4858
Col28a1 4763
Pcolce 4733
Col6a3 4621
Col15a1 4606
Plod1 4559
Col9a3 3789
Ppib 3226
Col18a1 3050
Col24a1 2997
Col1a1 2599
Col4a5 2486
Col17a1 2390
Col6a5 2356
Col20a1 1863
Col4a3 1850
Pcolce2 1603
Col11a1 1221
Tll2 1166
Plod2 558
Adamts14 546
Col14a1 -449
Col19a1 -590
Col8a1 -758
Col4a1 -844
Col5a1 -939
P4hb -1563
Crtap -3463
Col23a1 -3675
Tll1 -3733
Colgalt2 -3764
Col9a1 -4500
Col6a6 -5128
Col25a1 -5179
Col22a1 -5346
Adamts2 -5585
P3h2 -5829
Adamts3 -6206
Col8a2 -7555


NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD
629
set NONSENSE MEDIATED DECAY NMD
setSize 109
pANOVA 4.09e-10
s.dist 0.347
p.adjustANOVA 7.95e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps28 7597
Upf3a 7470
Rps8 7450
Rpl26 7359
Rpl28 7124
Rpl38 6634
Rplp2 6619
Rps29 6609
Rpl35 6264
Rpl23a 6154
Rps13 5967
Upf2 5920
Rps27a 5852
Upf3b 5809
Eif4g1 5754
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps28 7597
Upf3a 7470
Rps8 7450
Rpl26 7359
Rpl28 7124
Rpl38 6634
Rplp2 6619
Rps29 6609
Rpl35 6264
Rpl23a 6154
Rps13 5967
Upf2 5920
Rps27a 5852
Upf3b 5809
Eif4g1 5754
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531
Rpl37 5530
Rps19 5400
Rpl6 5381
Rbm8a 5293
Rps18 5259
Rpl8 5182
Casc3 5113
Rps27l 4781
Eif4a3 4762
Rpl35a 4749
Upf1 4646
Rplp1 4497
Rpl7a 4489
Rpl24 4485
Rps25 4349
Rps3a1 4211
Rpl14 4027
Rpl32 4021
Rpl13 3983
Rps17 3940
Rps11 3934
Rpl18a 3929
Uba52 3876
Rpl12 3790
Rpl10 3755
Rps6 3747
Fau 3714
Rpl30 3435
Rps16 3425
Rpl31 3267
Magohb 3263
Rps14 3149
Rps24 3077
Rps15 3027
Rpl21 3024
Rps10 2979
Rpl27a 2892
Rpl36al 2751
Rps7 2731
Rpl19 2668
Rpl3 2654
Rpsa 2614
Rpl36 2443
Rpl11 2320
Rps5 2249
Smg5 2199
Rnps1 1880
Rpl18 1869
Ncbp2 1712
Smg9 1705
Rps27 1669
Rpl9 1493
Gspt2 1418
Rpl5 1297
Rps12 1217
Rpl36a 927
Rpl10a 895
Rpl4 873
Rps23 872
Rpl22 732
Ncbp1 630
Rpl27 529
Rpl13a 406
Ppp2r1a 137
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Pabpc1 -1124
Rpl7 -1359
Rps15a -1947
Magoh -2121
Smg8 -2131
Rpl39 -2430
Smg1 -2440
Ppp2ca -2528
Rpl17 -2699
Dcp1a -2707
Rpl15 -3330
Rpl22l1 -3372
Smg7 -3557
Smg6 -4273
Ppp2r2a -4883
Gspt1 -5233
Etf1 -6408
Pnrc2 -7733


AGGREPHAGY

AGGREPHAGY
42
set AGGREPHAGY
setSize 35
pANOVA 0.00052
s.dist 0.339
p.adjustANOVA 0.0164



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsf1 7863
Prkn 7558
Tubb4a 7514
Vim 7137
Tubb3 7125
Dynll2 6857
Hdac6 6801
Rps27a 5852
Tubb6 5562
Cftr 4729
Vcp 4709
Park7 4550
Dync1h1 4204
Uba52 3876
Tuba1b 3388
Ubc 3089
Tuba4a 2983
Pcnt 2632
Ubb 2615
Arl13b 1722

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsf1 7863
Prkn 7558
Tubb4a 7514
Vim 7137
Tubb3 7125
Dynll2 6857
Hdac6 6801
Rps27a 5852
Tubb6 5562
Cftr 4729
Vcp 4709
Park7 4550
Dync1h1 4204
Uba52 3876
Tuba1b 3388
Ubc 3089
Tuba4a 2983
Pcnt 2632
Ubb 2615
Arl13b 1722
Tubb4b 1266
Dync1li1 1232
Tubb2a 982
Tuba8 723
Tubb2b 597
Dync1i1 565
Ift88 268
Ube2v1 -76
Tuba1c -502
Tuba1a -1498
Dynll1 -2176
Dync1i2 -2459
Dync1li2 -3015
Hsp90aa1 -5314
Ube2n -6198


ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES

ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
73
set ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
setSize 10
pANOVA 0.0637
s.dist -0.339
p.adjustANOVA 0.449



Top enriched genes

Top 20 genes
GeneID Gene Rank
Angptl4 -8438
Lpl -8375
Creb3l3 -7989
Mbtps2 -7343
Pcsk5 -5807
Mbtps1 -2771
Lmf2 1837
Lmf1 1892
Furin 2198
Pcsk6 2268

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Angptl4 -8438
Lpl -8375
Creb3l3 -7989
Mbtps2 -7343
Pcsk5 -5807
Mbtps1 -2771
Lmf2 1837
Lmf1 1892
Furin 2198
Pcsk6 2268


COMPLEMENT CASCADE

COMPLEMENT CASCADE
168
set COMPLEMENT CASCADE
setSize 22
pANOVA 0.00603
s.dist 0.338
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6966
Serping1 6861
Masp2 5994
C4b 4905
Clu 4790
C1qc 4382
Cd46 4241
C8g 3014
C1qa 3001
Masp1 2826
Cfh 2570
Cr1l 1928
Pros1 1027
Cd81 869
Cd55 766
Gzmm -547
Cd59b -1263
C3ar1 -2345

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
C2 7830
Cfp 7752
C1qb 6966
Serping1 6861
Masp2 5994
C4b 4905
Clu 4790
C1qc 4382
Cd46 4241
C8g 3014
C1qa 3001
Masp1 2826
Cfh 2570
Cr1l 1928
Pros1 1027
Cd81 869
Cd55 766
Gzmm -547
Cd59b -1263
C3ar1 -2345
Vtn -4402
Cfb -7716


ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS

ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS
884
set ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS
setSize 22
pANOVA 0.00603
s.dist 0.338
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pla2g6 7864
Plpp4 7854
Itpr3 7751
Prkcd 7667
Plcg1 7468
Pld1 6608
Fcgr3 5696
Itpr2 5108
Fcgr1 5036
Pld2 5001
Plpp5 3070
Plcg2 2455
Pik3r2 1777
Pik3ca 1397
Pld3 488
Ahcyl1 -536
Pld4 -741
Pik3r1 -2773
Syk -2933
Pik3cb -3280

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pla2g6 7864
Plpp4 7854
Itpr3 7751
Prkcd 7667
Plcg1 7468
Pld1 6608
Fcgr3 5696
Itpr2 5108
Fcgr1 5036
Pld2 5001
Plpp5 3070
Plcg2 2455
Pik3r2 1777
Pik3ca 1397
Pld3 488
Ahcyl1 -536
Pld4 -741
Pik3r1 -2773
Syk -2933
Pik3cb -3280
Itpr1 -3732
Prkce -7798


MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS

MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS
528
set MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS
setSize 18
pANOVA 0.0132
s.dist -0.337
p.adjustANOVA 0.18



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn4 -8441
Slc2a3 -8428
Oprk1 -8305
Met -7793
Creb1 -7647
Gria2 -7584
Grin2a -7389
Grin2b -6592
Mecp2 -5261
Hdac2 -4517
Trpc3 -3236
Gprin1 -2848
Sin3a -516
Oprm1 -230
Notch1 4059
Ptpn1 4215
Hdac1 4224
Fkbp5 7973

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn4 -8441
Slc2a3 -8428
Oprk1 -8305
Met -7793
Creb1 -7647
Gria2 -7584
Grin2a -7389
Grin2b -6592
Mecp2 -5261
Hdac2 -4517
Trpc3 -3236
Gprin1 -2848
Sin3a -516
Oprm1 -230
Notch1 4059
Ptpn1 4215
Hdac1 4224
Fkbp5 7973


CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS
189
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 14
pANOVA 0.029
s.dist 0.337
p.adjustANOVA 0.296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Bmp1 7814
Col1a2 7492
Loxl3 7065
Col4a2 5670
Pcolce 4733
Col1a1 2599
Col4a5 2486
Col4a3 1850
Loxl1 1235
Tll2 1166
Pxdn 1009
Col4a1 -844
Tll1 -3733
Lox -4657

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bmp1 7814
Col1a2 7492
Loxl3 7065
Col4a2 5670
Pcolce 4733
Col1a1 2599
Col4a5 2486
Col4a3 1850
Loxl1 1235
Tll2 1166
Pxdn 1009
Col4a1 -844
Tll1 -3733
Lox -4657


SEMA4D IN SEMAPHORIN SIGNALING

SEMA4D IN SEMAPHORIN SIGNALING
908
set SEMA4D IN SEMAPHORIN SIGNALING
setSize 24
pANOVA 0.00468
s.dist 0.334
p.adjustANOVA 0.0976



Top enriched genes

Top 20 genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7493
Limk2 7421
Plxnb1 6902
Limk1 6628
Myh9 6341
Rras 6066
Rhoc 5770
Rnd1 5407
Myl6 4895
Myl12b 4330
Myh10 3504
Arhgap35 2431
Arhgef11 2057
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2059

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7493
Limk2 7421
Plxnb1 6902
Limk1 6628
Myh9 6341
Rras 6066
Rhoc 5770
Rnd1 5407
Myl6 4895
Myl12b 4330
Myh10 3504
Arhgap35 2431
Arhgef11 2057
Erbb2 8
Sema4d -257
Rock2 -657
Rock1 -1112
Arhgef12 -2059
Rhoa -3484
Rhob -5010
Rac1 -7094
Met -7793


ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING

ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING
300
set ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING
setSize 21
pANOVA 0.00855
s.dist -0.332
p.adjustANOVA 0.139



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mapk1 -8630
Creb1 -7647
Akt3 -7429
Btc -6799
Cdkn1b -6707
Uhmk1 -6500
Elk1 -5299
Foxo3 -5228
Xpo1 -4807
Ccnd1 -4628
Egf -4464
Tgfa -3521
Fos -2716
Srf -1840
Ptk2 -1711
Mapk3 -652
Egfr -281
Akt2 1546
Hbegf 1766
Akt1 2472

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk1 -8630
Creb1 -7647
Akt3 -7429
Btc -6799
Cdkn1b -6707
Uhmk1 -6500
Elk1 -5299
Foxo3 -5228
Xpo1 -4807
Ccnd1 -4628
Egf -4464
Tgfa -3521
Fos -2716
Srf -1840
Ptk2 -1711
Mapk3 -652
Egfr -281
Akt2 1546
Hbegf 1766
Akt1 2472
Bcl2 6063


SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM
905
set SELENOAMINO ACID METABOLISM
setSize 108
pANOVA 2.69e-09
s.dist 0.331
p.adjustANOVA 4.36e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ahcy 7694
Rps28 7597
Rps8 7450
Gnmt 7447
Rpl26 7359
Rpl28 7124
Rpl38 6634
Sars 6629
Rplp2 6619
Rps29 6609
Aimp2 6285
Rpl35 6264
Mars1 6189
Rpl23a 6154
Secisbp2 6007
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ahcy 7694
Rps28 7597
Rps8 7450
Gnmt 7447
Rpl26 7359
Rpl28 7124
Rpl38 6634
Sars 6629
Rplp2 6619
Rps29 6609
Aimp2 6285
Rpl35 6264
Mars1 6189
Rpl23a 6154
Secisbp2 6007
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531
Rpl37 5530
Rps19 5400
Rpl6 5381
Rps18 5259
Rpl8 5182
Rps27l 4781
Rpl35a 4749
Rplp1 4497
Rpl7a 4489
Rpl24 4485
Rps25 4349
Rps3a1 4211
Rpl14 4027
Rpl32 4021
Rpl13 3983
Rps17 3940
Rps11 3934
Rpl18a 3929
Uba52 3876
Rpl12 3790
Rpl10 3755
Rps6 3747
Fau 3714
Rpl30 3435
Rps16 3425
Iars 3409
Rpl31 3267
Rps14 3149
Rps24 3077
Rps15 3027
Rpl21 3024
Rps10 2979
Rpl27a 2892
Rpl36al 2751
Rps7 2731
Cbs 2675
Rpl19 2668
Rpl3 2654
Rpsa 2614
Eprs 2605
Rpl36 2443
Rpl11 2320
Rps5 2249
Rpl18 1869
Rps27 1669
Rpl9 1493
Aimp1 1374
Rpl5 1297
Rps12 1217
Papss1 1045
Rpl36a 927
Scly 914
Rpl10a 895
Rpl4 873
Rps23 872
Rpl22 732
Rpl27 529
Rpl13a 406
Eefsec 40
Rps20 -240
Kars -285
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Eef1e1 -1262
Cth -1320
Rpl7 -1359
Lars -1628
Rps15a -1947
Rpl39 -2430
Rpl17 -2699
Rars -3016
Qars -3269
Rpl15 -3330
Gsr -3354
Rpl22l1 -3372
Pstk -3567
Txnrd1 -3581
Papss2 -5732
Sepsecs -6611
Dars -7284
Hnmt -7349
Sephs2 -7623


P75NTR SIGNALS VIA NF KB

P75NTR SIGNALS VIA NF KB
675
set P75NTR SIGNALS VIA NF KB
setSize 16
pANOVA 0.025
s.dist 0.324
p.adjustANOVA 0.273



Top enriched genes

Top 20 genes
GeneID Gene Rank
Myd88 6716
Ikbkb 6593
Nfkb1 6575
Irak1 6335
Rps27a 5852
Ngfr 5541
Uba52 3876
Ubc 3089
Ubb 2615
Ngf 2468
Nfkbia 2118
Sqstm1 727
Rela 29
Ripk2 -3192
Traf6 -3825
Prkci -8596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myd88 6716
Ikbkb 6593
Nfkb1 6575
Irak1 6335
Rps27a 5852
Ngfr 5541
Uba52 3876
Ubc 3089
Ubb 2615
Ngf 2468
Nfkbia 2118
Sqstm1 727
Rela 29
Ripk2 -3192
Traf6 -3825
Prkci -8596


ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS

ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS
6
set ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS
setSize 17
pANOVA 0.0225
s.dist -0.32
p.adjustANOVA 0.257



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdkn1a -8508
E2f3 -6816
Cdkn1b -6707
Rb1 -6356
Ccne2 -5713
E2f2 -5139
E2f1 -4656
Ccnd2 -4633
Ccnd1 -4628
Cdkn1c -4601
Tfdp2 -3110
Cdk6 -2299
Tfdp1 -2272
Cdk4 2011
Ccne1 2945
Cdk2 2990
Ccnd3 4933

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdkn1a -8508
E2f3 -6816
Cdkn1b -6707
Rb1 -6356
Ccne2 -5713
E2f2 -5139
E2f1 -4656
Ccnd2 -4633
Ccnd1 -4628
Cdkn1c -4601
Tfdp2 -3110
Cdk6 -2299
Tfdp1 -2272
Cdk4 2011
Ccne1 2945
Cdk2 2990
Ccnd3 4933


CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND

CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
117
set CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND
setSize 10
pANOVA 0.0806
s.dist -0.319
p.adjustANOVA 0.48



Top enriched genes

Top 20 genes
GeneID Gene Rank
Casp3 -7553
Dcc -7423
Unc5b -6259
Appl1 -5628
Dapk2 -4725
Casp9 -4449
Maged1 -3228
Unc5a -2134
Dapk1 4834
Dapk3 5681

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Casp3 -7553
Dcc -7423
Unc5b -6259
Appl1 -5628
Dapk2 -4725
Casp9 -4449
Maged1 -3228
Unc5a -2134
Dapk1 4834
Dapk3 5681


ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES

ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
74
set ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES
setSize 51
pANOVA 8.18e-05
s.dist 0.319
p.adjustANOVA 0.00354



Top enriched genes

Top 20 genes
GeneID Gene Rank
Bmp1 7814
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7492
Loxl3 7065
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Col6a2 6291
Plec 6231
Col3a1 5984
Col6a1 5959
Col4a2 5670
Ctsl 4853
Pcolce 4733
Col6a3 4621
Col15a1 4606

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bmp1 7814
Col9a2 7757
Col27a1 7737
Col11a2 7685
Col12a1 7671
Col1a2 7492
Loxl3 7065
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Col6a2 6291
Plec 6231
Col3a1 5984
Col6a1 5959
Col4a2 5670
Ctsl 4853
Pcolce 4733
Col6a3 4621
Col15a1 4606
Col9a3 3789
Col18a1 3050
Col24a1 2997
Cd151 2679
Col1a1 2599
Col4a5 2486
Col17a1 2390
Col6a5 2356
Mmp9 1954
Col4a3 1850
Dst 1522
Lamb3 1434
Loxl1 1235
Col11a1 1221
Tll2 1166
Pxdn 1009
Col14a1 -449
Itgb4 -468
Col8a1 -758
Col4a1 -844
Itga6 -930
Col5a1 -939
Ctsb -1721
Ctss -1913
Tll1 -3733
Col9a1 -4500
Lox -4657
Col6a6 -5128
Lamc2 -5811
Col8a2 -7555
Lama3 -8651


SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
1004
set SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize 106
pANOVA 1.55e-08
s.dist 0.318
p.adjustANOVA 1.81e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps28 7597
Rps8 7450
Rpl26 7359
Rpl28 7124
Rpl38 6634
Rplp2 6619
Rps29 6609
Rpl35 6264
Rpl23a 6154
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531
Rpl37 5530
Rps19 5400

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps28 7597
Rps8 7450
Rpl26 7359
Rpl28 7124
Rpl38 6634
Rplp2 6619
Rps29 6609
Rpl35 6264
Rpl23a 6154
Rps13 5967
Rps27a 5852
Rps21 5714
Rps2 5693
Rpl23 5633
Rps9 5593
Rpl37a 5545
Rps4x 5533
Rps26 5531
Rpl37 5530
Rps19 5400
Rpl6 5381
Rps18 5259
Rpl8 5182
Srp72 5118
Srpr 4813
Rps27l 4781
Rpl35a 4749
Rplp1 4497
Rpl7a 4489
Rpl24 4485
Rps25 4349
Rps3a1 4211
Sec11c 4176
Rpl14 4027
Rpl32 4021
Rpl13 3983
Rps17 3940
Rps11 3934
Rpl18a 3929
Uba52 3876
Srprb 3806
Rpl12 3790
Rpl10 3755
Rps6 3747
Fau 3714
Rpl30 3435
Rps16 3425
Srp19 3357
Rpl31 3267
Sec11a 3241
Rps14 3149
Rps24 3077
Rps15 3027
Rpl21 3024
Rps10 2979
Rpl27a 2892
Rpl36al 2751
Rps7 2731
Rpl19 2668
Rpl3 2654
Rpsa 2614
Rpl36 2443
Rpl11 2320
Rps5 2249
Rpl18 1869
Rpn2 1760
Sec61a2 1735
Rps27 1669
Rpl9 1493
Rpl5 1297
Rps12 1217
Sec61b 1077
Srp68 978
Srp14 947
Rpl36a 927
Rpl10a 895
Rpl4 873
Rps23 872
Spcs1 764
Rpl22 732
Rpl27 529
Rpl13a 406
Ssr4 -188
Rps20 -240
Rplp0 -309
Rpl29 -312
Rpl34 -373
Rps3 -775
Spcs2 -1146
Rpl7 -1359
Ddost -1477
Rps15a -1947
Sec61a1 -2415
Rpl39 -2430
Ssr2 -2654
Rpl17 -2699
Srp9 -3121
Rpl15 -3330
Rpl22l1 -3372
Rpn1 -4199
Sec61g -4276
Ssr1 -5676
Srp54a -5701
Ssr3 -5770
Spcs3 -7102
Tram1 -8162


FERTILIZATION

FERTILIZATION
317
set FERTILIZATION
setSize 12
pANOVA 0.0567
s.dist 0.318
p.adjustANOVA 0.434



Top enriched genes

Top 20 genes
GeneID Gene Rank
Izumo4 7532
Catsperg1 6963
Ovgp1 6808
Catsperd 6036
Adam21 4738
Catsperg2 4262
Catsper2 2372
Kcnu1 1703
Acr 619
B4galt1 -3841
Cd9 -4535
Hvcn1 -5555

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Izumo4 7532
Catsperg1 6963
Ovgp1 6808
Catsperd 6036
Adam21 4738
Catsperg2 4262
Catsper2 2372
Kcnu1 1703
Acr 619
B4galt1 -3841
Cd9 -4535
Hvcn1 -5555


POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
722
set POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize 17
pANOVA 0.0236
s.dist 0.317
p.adjustANOVA 0.262



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4a 7514
Tubb3 7125
Tubb6 5562
Arl2 4776
Tbcb 4619
Tbca 4002
Tuba1b 3388
Tuba4a 2983
Tbcd 2217
Tubb4b 1266
Tubb2a 982
Tuba8 723
Tubb2b 597
Tbcc -144
Tuba1c -502
Tuba1a -1498
Tbce -5313

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 7514
Tubb3 7125
Tubb6 5562
Arl2 4776
Tbcb 4619
Tbca 4002
Tuba1b 3388
Tuba4a 2983
Tbcd 2217
Tubb4b 1266
Tubb2a 982
Tuba8 723
Tubb2b 597
Tbcc -144
Tuba1c -502
Tuba1a -1498
Tbce -5313


TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
1129
set TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize 13
pANOVA 0.0478
s.dist 0.317
p.adjustANOVA 0.387



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb4a 7514
Tubb3 7125
Tubb6 5562
Tuba1b 3388
Tuba4a 2983
Gjb2 1872
Tubb4b 1266
Tubb2a 982
Tuba8 723
Tubb2b 597
Tuba1c -502
Gja1 -720
Tuba1a -1498

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb4a 7514
Tubb3 7125
Tubb6 5562
Tuba1b 3388
Tuba4a 2983
Gjb2 1872
Tubb4b 1266
Tubb2a 982
Tuba8 723
Tubb2b 597
Tuba1c -502
Gja1 -720
Tuba1a -1498


CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
123
set CD28 DEPENDENT VAV1 PATHWAY
setSize 11
pANOVA 0.0687
s.dist -0.317
p.adjustANOVA 0.449



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pak1 -7266
Rac1 -7094
Cd86 -6957
Cdc42 -6790
Lck -5243
Fyn -4003
Pak3 -3689
Grb2 -3233
Pak2 -2269
Cd80 5006
Vav1 7763

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pak1 -7266
Rac1 -7094
Cd86 -6957
Cdc42 -6790
Lck -5243
Fyn -4003
Pak3 -3689
Grb2 -3233
Pak2 -2269
Cd80 5006
Vav1 7763


NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
634
set NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 11
pANOVA 0.0708
s.dist -0.315
p.adjustANOVA 0.449



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hes1 -8398
Creb1 -7647
Rbpj -6451
Fcer2a -6103
Mamld1 -6045
Maml1 -5814
Maml2 -3706
Ep300 -801
Notch2 1342
Maml3 3509
Hes5 6550

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hes1 -8398
Creb1 -7647
Rbpj -6451
Fcer2a -6103
Mamld1 -6045
Maml1 -5814
Maml2 -3706
Ep300 -801
Notch2 1342
Maml3 3509
Hes5 6550


INSULIN PROCESSING

INSULIN PROCESSING
449
set INSULIN PROCESSING
setSize 24
pANOVA 0.00789
s.dist -0.313
p.adjustANOVA 0.132



Top enriched genes

Top 20 genes
GeneID Gene Rank
Exoc5 -8628
Exoc6 -8582
Slc30a5 -8069
Pcsk2 -7692
Exoc2 -6922
Slc30a7 -6645
Ero1a -6454
Myrip -5647
Kif5c -5367
Cpe -5080
Myo5a -5057
Kif5b -3438
Exoc1 -3319
Ero1b -2868
Rab27a -2778
Kif5a -2298
Pcsk1 -1677
Slc30a6 -1209
Vamp2 -235
Exoc3 451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Exoc5 -8628
Exoc6 -8582
Slc30a5 -8069
Pcsk2 -7692
Exoc2 -6922
Slc30a7 -6645
Ero1a -6454
Myrip -5647
Kif5c -5367
Cpe -5080
Myo5a -5057
Kif5b -3438
Exoc1 -3319
Ero1b -2868
Rab27a -2778
Kif5a -2298
Pcsk1 -1677
Slc30a6 -1209
Vamp2 -235
Exoc3 451
Stx1a 1991
Exoc8 4506
Exoc4 4818
Exoc7 7290


RHO GTPASES ACTIVATE ROCKS

RHO GTPASES ACTIVATE ROCKS
848
set RHO GTPASES ACTIVATE ROCKS
setSize 19
pANOVA 0.0184
s.dist 0.313
p.adjustANOVA 0.227



Top enriched genes

Top 20 genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7493
Limk2 7421
Limk1 6628
Myh9 6341
Rhoc 5770
Myl6 4895
Myl12b 4330
Myh10 3504
Ppp1r12a 1973
Ppp1r12b 1690
Cfl1 3
Rock2 -657
Rock1 -1112
Rhoa -3484
Rhob -5010
Ppp1cb -6009
Pak1 -7266

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myl9 7852
Myh11 7708
Myh14 7493
Limk2 7421
Limk1 6628
Myh9 6341
Rhoc 5770
Myl6 4895
Myl12b 4330
Myh10 3504
Ppp1r12a 1973
Ppp1r12b 1690
Cfl1 3
Rock2 -657
Rock1 -1112
Rhoa -3484
Rhob -5010
Ppp1cb -6009
Pak1 -7266


PEXOPHAGY

PEXOPHAGY
687
set PEXOPHAGY
setSize 11
pANOVA 0.0755
s.dist 0.31
p.adjustANOVA 0.468



Top enriched genes

Top 20 genes
GeneID Gene Rank
Epas1 7120
Pex5 5945
Rps27a 5852
Uba52 3876
Ubc 3089
Ubb 2615
Map1lc3b 2184
Nbr1 1545
Sqstm1 727
Usp30 -445
Atm -8415

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Epas1 7120
Pex5 5945
Rps27a 5852
Uba52 3876
Ubc 3089
Ubb 2615
Map1lc3b 2184
Nbr1 1545
Sqstm1 727
Usp30 -445
Atm -8415


TIGHT JUNCTION INTERACTIONS

TIGHT JUNCTION INTERACTIONS
1071
set TIGHT JUNCTION INTERACTIONS
setSize 18
pANOVA 0.0231
s.dist -0.309
p.adjustANOVA 0.26



Top enriched genes

Top 20 genes
GeneID Gene Rank
Crb3 -8748
Prkci -8596
Cldn3 -8209
Cldn2 -7403
Cldn1 -6903
Pard6b -5977
Pard6g -5913
Pard6a -5895
Cldn5 -4581
Cldn10 -3261
Pals1 -2577
Cldn23 -1580
Cldn12 -1182
F11r 462
Cldn11 1022
Pard3 3801
Cldn14 5169
Patj 6287

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Crb3 -8748
Prkci -8596
Cldn3 -8209
Cldn2 -7403
Cldn1 -6903
Pard6b -5977
Pard6g -5913
Pard6a -5895
Cldn5 -4581
Cldn10 -3261
Pals1 -2577
Cldn23 -1580
Cldn12 -1182
F11r 462
Cldn11 1022
Pard3 3801
Cldn14 5169
Patj 6287


E2F MEDIATED REGULATION OF DNA REPLICATION

E2F MEDIATED REGULATION OF DNA REPLICATION
270
set E2F MEDIATED REGULATION OF DNA REPLICATION
setSize 19
pANOVA 0.0205
s.dist -0.307
p.adjustANOVA 0.236



Top enriched genes

Top 20 genes
GeneID Gene Rank
Orc3 -8141
Ppp2cb -8046
Orc5 -7741
Orc4 -6544
Rb1 -6356
Orc6 -5379
E2f1 -4656
Tfdp2 -3110
Mcm8 -2883
Prim1 -2873
Ppp2ca -2528
Tfdp1 -2272
Orc2 -1709
Ppp2r1b -941
Prim2 -243
Ppp2r1a 137
Pola2 980
Pola1 1144
Ppp2r3d 4405

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Orc3 -8141
Ppp2cb -8046
Orc5 -7741
Orc4 -6544
Rb1 -6356
Orc6 -5379
E2f1 -4656
Tfdp2 -3110
Mcm8 -2883
Prim1 -2873
Ppp2ca -2528
Tfdp1 -2272
Orc2 -1709
Ppp2r1b -941
Prim2 -243
Ppp2r1a 137
Pola2 980
Pola1 1144
Ppp2r3d 4405


P75NTR RECRUITS SIGNALLING COMPLEXES

P75NTR RECRUITS SIGNALLING COMPLEXES
673
set P75NTR RECRUITS SIGNALLING COMPLEXES
setSize 13
pANOVA 0.0553
s.dist 0.307
p.adjustANOVA 0.427



Top enriched genes

Top 20 genes
GeneID Gene Rank
Myd88 6716
Ikbkb 6593
Irak1 6335
Rps27a 5852
Ngfr 5541
Uba52 3876
Ubc 3089
Ubb 2615
Ngf 2468
Sqstm1 727
Ripk2 -3192
Traf6 -3825
Prkci -8596

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Myd88 6716
Ikbkb 6593
Irak1 6335
Rps27a 5852
Ngfr 5541
Uba52 3876
Ubc 3089
Ubb 2615
Ngf 2468
Sqstm1 727
Ripk2 -3192
Traf6 -3825
Prkci -8596


RNA POLYMERASE II TRANSCRIPTION TERMINATION

RNA POLYMERASE II TRANSCRIPTION TERMINATION
874
set RNA POLYMERASE II TRANSCRIPTION TERMINATION
setSize 65
pANOVA 1.88e-05
s.dist 0.307
p.adjustANOVA 0.000998



Top enriched genes

Top 20 genes
GeneID Gene Rank
Srsf4 7950
Zc3h11a 7655
Snrpf 7556
Srsf9 7513
Cpsf1 7480
Dhx38 7462
Pabpn1 7401
Srsf2 7200
Ddx39a 7174
U2af1 7002
Alyref 6744
Srsf6 6718
Cpsf4 6689
Srrm1 6369
Cpsf7 6324
Sympk 5955
U2af1l4 5879
Ddx39b 5833
Upf3b 5809
Snrpb 5626

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Srsf4 7950
Zc3h11a 7655
Snrpf 7556
Srsf9 7513
Cpsf1 7480
Dhx38 7462
Pabpn1 7401
Srsf2 7200
Ddx39a 7174
U2af1 7002
Alyref 6744
Srsf6 6718
Cpsf4 6689
Srrm1 6369
Cpsf7 6324
Sympk 5955
U2af1l4 5879
Ddx39b 5833
Upf3b 5809
Snrpb 5626
U2af2 5490
Cstf3 5338
Srsf1 5312
Srsf11 5304
Rbm8a 5293
Sarnp 5125
Casc3 5113
Thoc6 4876
Eif4a3 4762
Thoc5 4461
Zfp473 4029
Cstf2 3654
Cpsf3 3473
Magohb 3263
Slu7 3125
Srsf5 2852
Poldip3 2055
Rnps1 1880
Ncbp2 1712
Snrpg 1226
Cstf1 1127
Thoc1 1115
Fip1l1 1013
Ncbp1 630
Papola 592
Wdr33 242
Snrpe 67
Chtop -246
Thoc7 -394
Lsm10 -1318
Srsf7 -1588
Magoh -2121
Nudt21 -2125
Cdc40 -2471
Pcf11 -2877
Srsf3 -3336
Thoc2 -3961
Lsm11 -5020
Snrpd3 -6248
Cstf2t -7252
Clp1 -7568
Thoc3 -7896
Slbp -7908
Cpsf2 -8203
Fyttd1 -8539


REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS
781
set REDUCTION OF CYTOSOLIC CA LEVELS
setSize 11
pANOVA 0.0804
s.dist -0.304
p.adjustANOVA 0.48



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc8a1 -8586
Calm1 -6803
Atp2b4 -6663
Atp2a2 -5583
Atp2b1 -4619
Sri -3789
Atp2a3 -1039
Slc8a2 -990
Atp2b3 -261
Atp2b2 400
Slc8a3 5314

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc8a1 -8586
Calm1 -6803
Atp2b4 -6663
Atp2a2 -5583
Atp2b1 -4619
Sri -3789
Atp2a3 -1039
Slc8a2 -990
Atp2b3 -261
Atp2b2 400
Slc8a3 5314


COLLAGEN DEGRADATION

COLLAGEN DEGRADATION
165
set COLLAGEN DEGRADATION
setSize 51
pANOVA 0.000187
s.dist 0.303
p.adjustANOVA 0.00726



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col11a2 7685
Col12a1 7671
Col1a2 7492
Col16a1 7367
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Col6a2 6291
Col3a1 5984
Col6a1 5959
Mmp19 5794
Col4a2 5670
Ctsl 4853
Col6a3 4621
Col15a1 4606
Mmp15 4535

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col13a1 7899
Col26a1 7772
Col9a2 7757
Col11a2 7685
Col12a1 7671
Col1a2 7492
Col16a1 7367
Col2a1 7012
Col5a2 6994
Col7a1 6814
Col5a3 6711
Col6a2 6291
Col3a1 5984
Col6a1 5959
Mmp19 5794
Col4a2 5670
Ctsl 4853
Col6a3 4621
Col15a1 4606
Mmp15 4535
Ctsk 4049
Col9a3 3789
Adam9 3081
Col18a1 3050
Tmprss6 2868
Col1a1 2599
Col4a5 2486
Col17a1 2390
Col6a5 2356
Furin 2198
Mmp9 1954
Col4a3 1850
Col11a1 1221
Phykpl 93
Col14a1 -449
Col19a1 -590
Ctsd -733
Col8a1 -758
Adam17 -843
Col4a1 -844
Col5a1 -939
Ctsb -1721
Mmp14 -3447
Col23a1 -3675
Col9a1 -4500
Col6a6 -5128
Col25a1 -5179
Mmp2 -5447
Adam10 -5747
Mmp11 -7537
Col8a2 -7555


LYSOSPHINGOLIPID AND LPA RECEPTORS

LYSOSPHINGOLIPID AND LPA RECEPTORS
519
set LYSOSPHINGOLIPID AND LPA RECEPTORS
setSize 12
pANOVA 0.0702
s.dist -0.302
p.adjustANOVA 0.449



Top enriched genes

Top 20 genes
GeneID Gene Rank
Plppr5 -8371
Plppr4 -7718
S1pr1 -6232
Plppr1 -6119
S1pr2 -5470
Lpar1 -3230
Lpar2 -2736
Plppr2 -2017
S1pr5 -1545
S1pr4 -703
S1pr3 2254
Plppr3 6567

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plppr5 -8371
Plppr4 -7718
S1pr1 -6232
Plppr1 -6119
S1pr2 -5470
Lpar1 -3230
Lpar2 -2736
Plppr2 -2017
S1pr5 -1545
S1pr4 -703
S1pr3 2254
Plppr3 6567


CGMP EFFECTS

CGMP EFFECTS
141
set CGMP EFFECTS
setSize 15
pANOVA 0.0432
s.dist -0.301
p.adjustANOVA 0.371



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pde1a -8709
Kcnma1 -7641
Prkg1 -6664
Kcnmb1 -5795
Pde11a -4241
Itpr1 -3732
Pde2a -3715
Pde9a -2935
Kcnmb4 -2881
Pde10a -2223
Pde5a -1891
Pde1b 313
Kcnmb2 1566
Irag1 2032
Prkg2 2417

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pde1a -8709
Kcnma1 -7641
Prkg1 -6664
Kcnmb1 -5795
Pde11a -4241
Itpr1 -3732
Pde2a -3715
Pde9a -2935
Kcnmb4 -2881
Pde10a -2223
Pde5a -1891
Pde1b 313
Kcnmb2 1566
Irag1 2032
Prkg2 2417


SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
1029
set SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
setSize 13
pANOVA 0.0602
s.dist 0.301
p.adjustANOVA 0.447



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptgis 7770
Slc27a2 6336
Rxra 5870
Cyp27a1 5848
Acot8 5801
Hsd17b4 4959
Hsd3b7 4665
Scp2 1613
Slc27a5 716
Cyp7b1 -698
Ncoa2 -4279
Ncoa1 -5337
Amacr -5715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptgis 7770
Slc27a2 6336
Rxra 5870
Cyp27a1 5848
Acot8 5801
Hsd17b4 4959
Hsd3b7 4665
Scp2 1613
Slc27a5 716
Cyp7b1 -698
Ncoa2 -4279
Ncoa1 -5337
Amacr -5715


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report