date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik 1.8312366
0610009E02Rik -0.1037028
0610009L18Rik -0.0756377
0610010K14Rik 0.4176706
0610012G03Rik 0.0087096
0610030E20Rik -1.6095238

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16611
duplicated_genes_present 0
num_profile_genes_in_sets 8254
num_profile_genes_not_in_sets 8357

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 437
num_genesets_included 1167

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 1.76e-04 0.653 1.66e-03
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 5.35e-04 0.555 4.39e-03
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 4.07e-05 0.544 5.10e-04
ASPARTATE AND ASPARAGINE METABOLISM 10 3.02e-03 0.542 1.72e-02
COMPLEX I BIOGENESIS 56 4.20e-12 0.535 2.88e-10
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 3.51e-05 0.534 4.55e-04
TRIGLYCERIDE CATABOLISM 14 6.68e-04 0.525 5.32e-03
PINK1 PRKN MEDIATED MITOPHAGY 22 2.44e-05 0.520 3.35e-04
FRS MEDIATED FGFR4 SIGNALING 12 1.92e-03 0.517 1.22e-02
SHC MEDIATED CASCADE FGFR4 10 4.74e-03 0.516 2.44e-02
EUKARYOTIC TRANSLATION ELONGATION 87 1.06e-16 0.514 1.12e-14
CRMPS IN SEMA3A SIGNALING 16 3.87e-04 -0.512 3.32e-03
RESPIRATORY ELECTRON TRANSPORT 102 4.50e-19 0.511 8.75e-17
CITRIC ACID CYCLE TCA CYCLE 22 3.54e-05 0.509 4.55e-04
PI 3K CASCADE FGFR4 10 5.34e-03 0.509 2.65e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.14e-22 0.504 5.00e-20
PLATELET SENSITIZATION BY LDL 15 7.66e-04 0.502 5.80e-03
FRS MEDIATED FGFR3 SIGNALING 14 1.21e-03 0.500 8.22e-03
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.28e-03 0.499 3.03e-02
SHC MEDIATED CASCADE FGFR3 12 2.96e-03 0.496 1.69e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 4.08e-06 0.494 8.50e-05
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 2.06e-03 0.494 1.29e-02
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.77e-18 0.490 3.59e-16
PI 3K CASCADE FGFR3 12 3.31e-03 0.490 1.82e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 1.13e-03 0.486 7.83e-03
RHOBTB3 ATPASE CYCLE 10 8.05e-03 0.484 3.70e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 3.84e-04 0.483 3.32e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.91e-10 0.479 1.01e-08
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 9.08e-03 0.476 4.11e-02
FATTY ACYL COA BIOSYNTHESIS 32 3.15e-06 0.476 6.80e-05
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 17 7.16e-04 0.474 5.57e-03
EUKARYOTIC TRANSLATION INITIATION 114 2.33e-18 0.474 3.40e-16
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 1.05e-03 0.473 7.50e-03
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 4.71e-03 0.471 2.43e-02
RAS PROCESSING 23 9.45e-05 0.470 9.89e-04
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.15e-26 0.470 8.35e-24
GLYCOGEN SYNTHESIS 14 2.42e-03 0.468 1.45e-02
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 4.97e-15 0.467 4.46e-13
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 1.97e-03 0.462 1.24e-02
G BETA GAMMA SIGNALLING THROUGH CDC42 18 7.75e-04 0.458 5.80e-03
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 1.23e-02 0.457 5.23e-02
GLYCOGEN STORAGE DISEASES 12 6.47e-03 0.454 3.11e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 4.42e-04 0.454 3.68e-03
PROTEIN METHYLATION 17 1.24e-03 0.452 8.39e-03
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 6.93e-03 0.450 3.26e-02
ENOS ACTIVATION 11 1.00e-02 0.448 4.44e-02
DARPP 32 EVENTS 23 2.28e-04 0.444 2.08e-03
MITOPHAGY 29 5.75e-05 0.432 6.65e-04
CRISTAE FORMATION 31 3.33e-05 0.431 4.46e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 7.20e-03 0.430 3.35e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 1.76e-04 6.53e-01 1.66e-03
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 5.35e-04 5.55e-01 4.39e-03
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 4.07e-05 5.44e-01 5.10e-04
ASPARTATE AND ASPARAGINE METABOLISM 10 3.02e-03 5.42e-01 1.72e-02
COMPLEX I BIOGENESIS 56 4.20e-12 5.35e-01 2.88e-10
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 3.51e-05 5.34e-01 4.55e-04
TRIGLYCERIDE CATABOLISM 14 6.68e-04 5.25e-01 5.32e-03
PINK1 PRKN MEDIATED MITOPHAGY 22 2.44e-05 5.20e-01 3.35e-04
FRS MEDIATED FGFR4 SIGNALING 12 1.92e-03 5.17e-01 1.22e-02
SHC MEDIATED CASCADE FGFR4 10 4.74e-03 5.16e-01 2.44e-02
EUKARYOTIC TRANSLATION ELONGATION 87 1.06e-16 5.14e-01 1.12e-14
CRMPS IN SEMA3A SIGNALING 16 3.87e-04 -5.12e-01 3.32e-03
RESPIRATORY ELECTRON TRANSPORT 102 4.50e-19 5.11e-01 8.75e-17
CITRIC ACID CYCLE TCA CYCLE 22 3.54e-05 5.09e-01 4.55e-04
PI 3K CASCADE FGFR4 10 5.34e-03 5.09e-01 2.65e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.14e-22 5.04e-01 5.00e-20
PLATELET SENSITIZATION BY LDL 15 7.66e-04 5.02e-01 5.80e-03
FRS MEDIATED FGFR3 SIGNALING 14 1.21e-03 5.00e-01 8.22e-03
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.28e-03 4.99e-01 3.03e-02
SHC MEDIATED CASCADE FGFR3 12 2.96e-03 4.96e-01 1.69e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 4.08e-06 4.94e-01 8.50e-05
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 2.06e-03 4.94e-01 1.29e-02
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.77e-18 4.90e-01 3.59e-16
PI 3K CASCADE FGFR3 12 3.31e-03 4.90e-01 1.82e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 15 1.13e-03 4.86e-01 7.83e-03
RHOBTB3 ATPASE CYCLE 10 8.05e-03 4.84e-01 3.70e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 3.84e-04 4.83e-01 3.32e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.91e-10 4.79e-01 1.01e-08
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 9.08e-03 4.76e-01 4.11e-02
FATTY ACYL COA BIOSYNTHESIS 32 3.15e-06 4.76e-01 6.80e-05
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 17 7.16e-04 4.74e-01 5.57e-03
EUKARYOTIC TRANSLATION INITIATION 114 2.33e-18 4.74e-01 3.40e-16
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 1.05e-03 4.73e-01 7.50e-03
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 4.71e-03 4.71e-01 2.43e-02
RAS PROCESSING 23 9.45e-05 4.70e-01 9.89e-04
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.15e-26 4.70e-01 8.35e-24
GLYCOGEN SYNTHESIS 14 2.42e-03 4.68e-01 1.45e-02
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 4.97e-15 4.67e-01 4.46e-13
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 1.97e-03 4.62e-01 1.24e-02
G BETA GAMMA SIGNALLING THROUGH CDC42 18 7.75e-04 4.58e-01 5.80e-03
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 1.23e-02 4.57e-01 5.23e-02
GLYCOGEN STORAGE DISEASES 12 6.47e-03 4.54e-01 3.11e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 4.42e-04 4.54e-01 3.68e-03
PROTEIN METHYLATION 17 1.24e-03 4.52e-01 8.39e-03
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 6.93e-03 4.50e-01 3.26e-02
ENOS ACTIVATION 11 1.00e-02 4.48e-01 4.44e-02
DARPP 32 EVENTS 23 2.28e-04 4.44e-01 2.08e-03
MITOPHAGY 29 5.75e-05 4.32e-01 6.65e-04
CRISTAE FORMATION 31 3.33e-05 4.31e-01 4.46e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 7.20e-03 4.30e-01 3.35e-02
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 1.49e-02 4.24e-01 6.12e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 1.10e-02 4.24e-01 4.76e-02
SIGNAL AMPLIFICATION 30 6.37e-05 4.22e-01 7.22e-04
SELENOAMINO ACID METABOLISM 107 8.65e-14 4.17e-01 6.73e-12
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.35e-02 4.12e-01 5.66e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 8.32e-04 4.12e-01 6.10e-03
BRANCHED CHAIN AMINO ACID CATABOLISM 21 1.11e-03 4.11e-01 7.79e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 7.80e-05 4.10e-01 8.35e-04
CTLA4 INHIBITORY SIGNALING 19 2.04e-03 4.09e-01 1.28e-02
CD28 DEPENDENT VAV1 PATHWAY 10 2.57e-02 4.07e-01 8.98e-02
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.26e-03 4.06e-01 8.43e-03
CALNEXIN CALRETICULIN CYCLE 26 3.51e-04 4.05e-01 3.08e-03
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 2.66e-02 4.05e-01 9.20e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 17 3.96e-03 4.04e-01 2.11e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 19 2.37e-03 4.03e-01 1.43e-02
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 9.77e-08 4.01e-01 3.26e-06
METABOLISM OF POLYAMINES 57 1.88e-07 3.99e-01 5.62e-06
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 7.52e-03 3.99e-01 3.48e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 7.34e-04 3.98e-01 5.64e-03
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 9.01e-07 3.98e-01 2.45e-05
GAP JUNCTION DEGRADATION 11 2.44e-02 3.92e-01 8.76e-02
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 6.35e-05 3.91e-01 7.22e-04
COMPLEMENT CASCADE 22 1.52e-03 3.91e-01 9.95e-03
TRP CHANNELS 19 3.30e-03 -3.89e-01 1.82e-02
GLUTATHIONE CONJUGATION 29 2.88e-04 3.89e-01 2.58e-03
GLYCOGEN METABOLISM 25 7.73e-04 3.88e-01 5.80e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 5.38e-06 3.88e-01 9.66e-05
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 5.84e-03 -3.86e-01 2.84e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 24 1.13e-03 3.84e-01 7.83e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.30e-06 3.81e-01 3.15e-05
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 9.98e-05 3.80e-01 1.03e-03
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 1.78e-02 3.80e-01 7.00e-02
TRANSLATION 286 2.36e-28 3.80e-01 1.38e-25
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.89e-02 3.76e-01 7.31e-02
GLUCONEOGENESIS 27 7.84e-04 3.73e-01 5.82e-03
MITOCHONDRIAL TRANSLATION 93 4.88e-10 3.73e-01 2.28e-08
NONSENSE MEDIATED DECAY NMD 109 2.12e-11 3.71e-01 1.30e-09
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 1.03e-02 3.70e-01 4.50e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES 307 7.70e-29 3.70e-01 8.99e-26
REGULATION OF EXPRESSION OF SLITS AND ROBOS 160 7.02e-16 3.70e-01 6.83e-14
METHYLATION 11 3.49e-02 3.67e-01 1.11e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 3.83e-06 3.67e-01 8.12e-05
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 3.54e-02 3.66e-01 1.11e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 4.32e-06 3.65e-01 8.69e-05
INSULIN RECEPTOR RECYCLING 20 4.85e-03 3.64e-01 2.45e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 2.53e-03 3.64e-01 1.50e-02
ERYTHROPOIETIN ACTIVATES RAS 13 2.34e-02 3.63e-01 8.50e-02
DEGRADATION OF GLI1 BY THE PROTEASOME 57 2.28e-06 3.62e-01 5.13e-05
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 8.84e-07 3.58e-01 2.45e-05
FGFR2 LIGAND BINDING AND ACTIVATION 12 3.18e-02 3.58e-01 1.03e-01
JOSEPHIN DOMAIN DUBS 11 4.02e-02 3.57e-01 1.23e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 4.04e-02 3.57e-01 1.23e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 2.59e-02 3.57e-01 9.03e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 3.27e-02 3.56e-01 1.06e-01
TRIGLYCERIDE METABOLISM 22 3.86e-03 3.56e-01 2.08e-02
HEDGEHOG LIGAND BIOGENESIS 61 1.54e-06 3.56e-01 3.68e-05
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 3.35e-02 3.55e-01 1.07e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 6.89e-08 3.53e-01 2.59e-06
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 3.50e-03 3.52e-01 1.91e-02
FRS MEDIATED FGFR2 SIGNALING 18 1.01e-02 3.50e-01 4.46e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 3.57e-02 3.50e-01 1.11e-01
IRON UPTAKE AND TRANSPORT 52 1.36e-05 3.49e-01 2.11e-04
CELLULAR RESPONSE TO STARVATION 145 5.04e-13 3.48e-01 3.68e-11
PYRUVATE METABOLISM 27 1.78e-03 3.48e-01 1.15e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 4.64e-02 3.47e-01 1.37e-01
STABILIZATION OF P53 54 1.07e-05 3.46e-01 1.74e-04
MITOCHONDRIAL PROTEIN IMPORT 63 2.21e-06 3.45e-01 5.05e-05
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 3.17e-02 3.44e-01 1.03e-01
RECEPTOR MEDIATED MITOPHAGY 11 4.89e-02 3.43e-01 1.41e-01
COLLAGEN CHAIN TRIMERIZATION 39 2.28e-04 -3.41e-01 2.08e-03
DEGRADATION OF AXIN 53 1.75e-05 3.41e-01 2.60e-04
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.02e-02 3.41e-01 1.44e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 6.96e-03 3.40e-01 3.26e-02
PENTOSE PHOSPHATE PATHWAY 13 3.56e-02 3.37e-01 1.11e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 7.85e-06 3.36e-01 1.37e-04
INITIAL TRIGGERING OF COMPLEMENT 10 6.56e-02 3.36e-01 1.78e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 2.09e-03 3.36e-01 1.29e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 1.59e-07 3.35e-01 5.02e-06
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 4.51e-02 3.34e-01 1.34e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 1.05e-05 3.32e-01 1.73e-04
GLUTATHIONE SYNTHESIS AND RECYCLING 11 5.77e-02 3.31e-01 1.59e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 2.28e-02 3.29e-01 8.36e-02
RHO GTPASES ACTIVATE WASPS AND WAVES 36 6.50e-04 3.28e-01 5.26e-03
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 2.80e-02 3.28e-01 9.54e-02
KILLING MECHANISMS 10 7.30e-02 -3.27e-01 1.92e-01
INTERACTION BETWEEN L1 AND ANKYRINS 29 2.29e-03 -3.27e-01 1.39e-02
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 6.04e-02 3.27e-01 1.66e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 7.21e-04 -3.26e-01 5.58e-03
REGULATION OF PTEN STABILITY AND ACTIVITY 66 4.92e-06 3.25e-01 9.19e-05
FCERI MEDIATED NF KB ACTIVATION 76 9.98e-07 3.25e-01 2.53e-05
PI 3K CASCADE FGFR2 16 2.49e-02 3.24e-01 8.76e-02
CELLULAR RESPONSE TO HYPOXIA 71 2.45e-06 3.24e-01 5.39e-05
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 1.05e-02 3.23e-01 4.58e-02
PKMTS METHYLATE HISTONE LYSINES 48 1.18e-04 -3.21e-01 1.16e-03
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 1.85e-02 3.21e-01 7.24e-02
PHASE II CONJUGATION OF COMPOUNDS 60 1.79e-05 3.20e-01 2.61e-04
ANTIGEN PROCESSING CROSS PRESENTATION 93 9.55e-08 3.20e-01 3.26e-06
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 4.77e-03 3.20e-01 2.44e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 1.94e-02 3.18e-01 7.41e-02
LDL CLEARANCE 16 2.78e-02 3.18e-01 9.51e-02
PROTEIN UBIQUITINATION 69 5.11e-06 3.18e-01 9.31e-05
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 3.38e-02 3.16e-01 1.08e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 1.23e-02 3.16e-01 5.23e-02
TIE2 SIGNALING 17 2.46e-02 3.15e-01 8.76e-02
G PROTEIN ACTIVATION 22 1.07e-02 3.14e-01 4.66e-02
SIGNALING BY FGFR4 IN DISEASE 10 8.54e-02 3.14e-01 2.11e-01
PROTEIN LOCALIZATION 156 1.41e-11 3.14e-01 9.14e-10
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 4.09e-03 3.14e-01 2.16e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.20e-02 -3.13e-01 1.90e-01
BUDDING AND MATURATION OF HIV VIRION 27 4.86e-03 3.13e-01 2.45e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 5.25e-04 3.13e-01 4.35e-03
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 3.18e-03 3.11e-01 1.78e-02
INFLAMMASOMES 19 1.90e-02 3.11e-01 7.31e-02
NUCLEOBASE BIOSYNTHESIS 15 3.71e-02 3.11e-01 1.15e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.88e-02 3.11e-01 2.17e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 1.38e-02 -3.11e-01 5.72e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING 23 1.00e-02 3.10e-01 4.44e-02
ANCHORING FIBRIL FORMATION 13 5.33e-02 -3.10e-01 1.50e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 1.48e-05 3.08e-01 2.25e-04
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 4.63e-02 3.08e-01 1.37e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 9.24e-02 -3.07e-01 2.24e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 1.26e-02 3.07e-01 5.33e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 2.09e-02 3.06e-01 7.75e-02
FATTY ACID METABOLISM 146 1.73e-10 3.06e-01 9.63e-09
IRAK4 DEFICIENCY TLR2 4 12 6.64e-02 3.06e-01 1.79e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 9.23e-08 3.05e-01 3.26e-06
INFLUENZA INFECTION 145 2.48e-10 3.05e-01 1.26e-08
DEGRADATION OF DVL 55 9.49e-05 3.04e-01 9.89e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.59e-03 3.03e-01 1.53e-02
SIGNALING BY ROBO RECEPTORS 205 8.18e-14 3.03e-01 6.73e-12
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 1.20e-02 3.03e-01 5.15e-02
SIGNALING BY FGFR4 31 3.57e-03 3.02e-01 1.94e-02
NEGATIVE REGULATION OF FGFR4 SIGNALING 21 1.65e-02 3.02e-01 6.62e-02
RHOBTB2 GTPASE CYCLE 23 1.24e-02 3.01e-01 5.25e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 8.47e-02 3.00e-01 2.11e-01
ORC1 REMOVAL FROM CHROMATIN 67 2.32e-05 2.99e-01 3.23e-04
GPVI MEDIATED ACTIVATION CASCADE 31 3.98e-03 2.99e-01 2.11e-02
FRS MEDIATED FGFR1 SIGNALING 17 3.31e-02 2.99e-01 1.07e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 3.81e-05 2.98e-01 4.83e-04
ABC TRANSPORTER DISORDERS 69 1.95e-05 2.97e-01 2.78e-04
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 8.89e-02 -2.96e-01 2.17e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 32 3.83e-03 2.95e-01 2.07e-02
SULFUR AMINO ACID METABOLISM 22 1.66e-02 2.95e-01 6.62e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 5.70e-02 2.94e-01 1.58e-01
SEROTONIN RECEPTORS 10 1.09e-01 2.93e-01 2.50e-01
AQUAPORIN MEDIATED TRANSPORT 40 1.37e-03 2.93e-01 9.08e-03
CLEC7A DECTIN 1 SIGNALING 94 9.62e-07 2.92e-01 2.49e-05
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 69 2.90e-05 2.91e-01 3.93e-04
SARS COV 2 INFECTION 65 4.96e-05 2.91e-01 6.03e-04
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 6.69e-03 2.91e-01 3.19e-02
SCAVENGING BY CLASS A RECEPTORS 13 6.96e-02 2.91e-01 1.86e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 4.19e-06 2.91e-01 8.58e-05
CHAPERONE MEDIATED AUTOPHAGY 20 2.48e-02 2.90e-01 8.76e-02
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 6.00e-03 -2.90e-01 2.91e-02
LYSOSOME VESICLE BIOGENESIS 33 3.98e-03 2.90e-01 2.11e-02
C TYPE LECTIN RECEPTORS CLRS 111 1.40e-07 2.89e-01 4.53e-06
ANTIMICROBIAL PEPTIDES 14 6.09e-02 2.89e-01 1.67e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.65e-02 2.89e-01 6.62e-02
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 1.08e-02 2.89e-01 4.66e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 3.42e-05 2.89e-01 4.54e-04
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 2.47e-03 2.88e-01 1.47e-02
BIOLOGICAL OXIDATIONS 123 3.92e-08 2.87e-01 1.53e-06
PLATELET ADHESION TO EXPOSED COLLAGEN 12 8.55e-02 2.87e-01 2.11e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 3.54e-02 -2.86e-01 1.11e-01
PROCESSING AND ACTIVATION OF SUMO 10 1.17e-01 2.86e-01 2.65e-01
MET RECEPTOR RECYCLING 10 1.18e-01 2.86e-01 2.65e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 1.02e-01 2.85e-01 2.39e-01
G1 S DNA DAMAGE CHECKPOINTS 65 7.62e-05 2.84e-01 8.31e-04
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 5.52e-03 2.83e-01 2.71e-02
PYROPTOSIS 20 2.91e-02 2.82e-01 9.80e-02
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 1.23e-01 -2.82e-01 2.74e-01
REGULATION OF RAS BY GAPS 66 7.79e-05 2.81e-01 8.35e-04
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 7.92e-02 2.81e-01 2.01e-01
RAF ACTIVATION 34 4.85e-03 2.79e-01 2.45e-02
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 6.55e-04 2.79e-01 5.27e-03
SIGNALING BY FGFR3 34 5.07e-03 2.78e-01 2.55e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.43e-02 2.77e-01 5.91e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 8.38e-02 2.77e-01 2.10e-01
HYALURONAN UPTAKE AND DEGRADATION 11 1.12e-01 2.77e-01 2.55e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 4.96e-06 2.74e-01 9.19e-05
RHO GTPASES ACTIVATE KTN1 11 1.16e-01 2.74e-01 2.63e-01
DERMATAN SULFATE BIOSYNTHESIS 11 1.16e-01 2.73e-01 2.64e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 1.72e-07 2.73e-01 5.28e-06
CELLULAR RESPONSE TO CHEMICAL STRESS 149 9.49e-09 2.73e-01 4.10e-07
INTERLEUKIN 12 SIGNALING 37 4.39e-03 2.71e-01 2.28e-02
SPHINGOLIPID METABOLISM 79 3.54e-05 2.69e-01 4.55e-04
SIGNALING BY RETINOIC ACID 32 8.61e-03 2.68e-01 3.94e-02
SHC MEDIATED CASCADE FGFR1 15 7.20e-02 2.68e-01 1.90e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 1.43e-02 -2.67e-01 5.91e-02
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 1.79e-06 2.67e-01 4.18e-05
TNFR2 NON CANONICAL NF KB PATHWAY 79 4.14e-05 2.67e-01 5.14e-04
CS DS DEGRADATION 14 8.45e-02 2.66e-01 2.11e-01
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 4.51e-02 2.66e-01 1.34e-01
SARS COV 1 INFECTION 48 1.48e-03 2.65e-01 9.77e-03
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 9.44e-03 -2.65e-01 4.22e-02
INTERLEUKIN 1 SIGNALING 95 8.20e-06 2.65e-01 1.41e-04
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 2.81e-02 2.65e-01 9.54e-02
PI 3K CASCADE FGFR1 15 7.71e-02 2.64e-01 1.98e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 7.77e-02 2.63e-01 1.99e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 2.94e-02 2.62e-01 9.89e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 25 2.32e-02 2.62e-01 8.46e-02
DNA REPLICATION PRE INITIATION 79 5.68e-05 2.62e-01 6.65e-04
CROSSLINKING OF COLLAGEN FIBRILS 13 1.03e-01 -2.61e-01 2.41e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 3.80e-04 2.61e-01 3.31e-03
RRNA PROCESSING 194 3.88e-10 2.61e-01 1.89e-08
DISEASES OF CARBOHYDRATE METABOLISM 29 1.52e-02 2.61e-01 6.20e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 80 5.75e-05 2.60e-01 6.65e-04
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.67e-04 2.60e-01 1.59e-03
INTERLEUKIN 12 FAMILY SIGNALING 44 2.87e-03 2.60e-01 1.65e-02
NEUTROPHIL DEGRANULATION 384 3.13e-18 2.59e-01 3.66e-16
FCERI MEDIATED CA 2 MOBILIZATION 26 2.21e-02 2.59e-01 8.15e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 3.98e-02 2.59e-01 1.22e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 1.06e-01 2.59e-01 2.47e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.21e-01 2.58e-01 2.71e-01
PEROXISOMAL LIPID METABOLISM 26 2.28e-02 2.58e-01 8.36e-02
PURINE CATABOLISM 16 7.49e-02 2.57e-01 1.95e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.65e-02 2.57e-01 6.62e-02
TCR SIGNALING 101 8.31e-06 2.57e-01 1.41e-04
SIGNALING BY BMP 24 2.95e-02 2.57e-01 9.89e-02
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 2.17e-02 2.55e-01 8.00e-02
SIGNALING BY NOTCH4 83 6.46e-05 2.54e-01 7.25e-04
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 2.06e-02 2.53e-01 7.68e-02
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 4.50e-02 2.53e-01 1.34e-01
G PROTEIN BETA GAMMA SIGNALLING 30 1.66e-02 2.53e-01 6.62e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 2.60e-02 2.52e-01 9.04e-02
SIGNALING BY INSULIN RECEPTOR 61 6.70e-04 2.52e-01 5.32e-03
KINESINS 47 2.83e-03 -2.52e-01 1.64e-02
INACTIVATION OF CSF3 G CSF SIGNALING 24 3.52e-02 2.48e-01 1.11e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 89 5.21e-05 2.48e-01 6.26e-04
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 81 1.18e-04 2.48e-01 1.16e-03
ARACHIDONIC ACID METABOLISM 40 6.78e-03 2.47e-01 3.21e-02
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 7.75e-02 -2.47e-01 1.99e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 4.04e-02 -2.47e-01 1.23e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 1.24e-01 2.47e-01 2.76e-01
NCAM1 INTERACTIONS 39 7.86e-03 -2.46e-01 3.62e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 8.42e-04 -2.45e-01 6.14e-03
PYRIMIDINE SALVAGE 10 1.80e-01 -2.45e-01 3.56e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 1.60e-01 2.44e-01 3.27e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 3.11e-02 2.44e-01 1.02e-01
MET ACTIVATES RAP1 AND RAC1 11 1.61e-01 2.44e-01 3.28e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 5.97e-02 2.43e-01 1.64e-01
METABOLISM OF COFACTORS 18 7.41e-02 2.43e-01 1.94e-01
INWARDLY RECTIFYING K CHANNELS 31 1.97e-02 2.42e-01 7.53e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.86e-01 -2.42e-01 3.64e-01
SIGNALING BY CSF3 G CSF 29 2.44e-02 2.41e-01 8.76e-02
CYTOPROTECTION BY HMOX1 119 5.68e-06 2.41e-01 1.00e-04
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 1.22e-04 2.40e-01 1.19e-03
GLUCAGON TYPE LIGAND RECEPTORS 23 4.68e-02 2.39e-01 1.38e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 3.20e-02 2.39e-01 1.04e-01
MAPK6 MAPK4 SIGNALING 83 1.82e-04 2.38e-01 1.70e-03
HOST INTERACTIONS OF HIV FACTORS 125 4.80e-06 2.37e-01 9.19e-05
SIGNALING BY ERBB2 ECD MUTANTS 16 1.01e-01 2.37e-01 2.39e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 225 9.53e-10 2.37e-01 4.28e-08
PHASE I FUNCTIONALIZATION OF COMPOUNDS 60 1.72e-03 2.34e-01 1.12e-02
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 5.80e-02 2.34e-01 1.60e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 9.58e-02 2.33e-01 2.31e-01
PROLONGED ERK ACTIVATION EVENTS 14 1.31e-01 2.33e-01 2.85e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 9.70e-04 2.33e-01 7.03e-03
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 23 5.38e-02 2.32e-01 1.51e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 1.08e-01 2.32e-01 2.48e-01
PEXOPHAGY 11 1.83e-01 2.32e-01 3.61e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 3.19e-03 2.30e-01 1.78e-02
S PHASE 153 9.39e-07 2.30e-01 2.49e-05
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.53e-01 -2.29e-01 3.18e-01
METALLOPROTEASE DUBS 25 4.77e-02 2.29e-01 1.39e-01
DAP12 INTERACTIONS 29 3.32e-02 2.28e-01 1.07e-01
INTERLEUKIN 1 FAMILY SIGNALING 123 1.27e-05 2.28e-01 2.03e-04
METABOLISM OF PORPHYRINS 19 8.58e-02 2.28e-01 2.11e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 7.94e-02 2.27e-01 2.01e-01
EARLY PHASE OF HIV LIFE CYCLE 14 1.43e-01 2.26e-01 3.03e-01
EPHRIN SIGNALING 19 8.78e-02 2.26e-01 2.16e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 11 1.97e-01 2.25e-01 3.76e-01
FORMATION OF APOPTOSOME 10 2.19e-01 2.25e-01 3.95e-01
RAB GERANYLGERANYLATION 58 3.16e-03 2.24e-01 1.78e-02
PEROXISOMAL PROTEIN IMPORT 57 3.45e-03 2.24e-01 1.89e-02
SIGNALING BY FGFR1 43 1.11e-02 2.24e-01 4.77e-02
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 5.82e-03 -2.23e-01 2.84e-02
PHASE 0 RAPID DEPOLARISATION 31 3.15e-02 -2.23e-01 1.03e-01
LGI ADAM INTERACTIONS 14 1.49e-01 -2.23e-01 3.12e-01
GABA RECEPTOR ACTIVATION 52 5.51e-03 2.23e-01 2.71e-02
RHO GTPASES ACTIVATE CIT 18 1.03e-01 2.22e-01 2.41e-01
GABA B RECEPTOR ACTIVATION 39 1.65e-02 2.22e-01 6.62e-02
N GLYCAN ANTENNAE ELONGATION 15 1.37e-01 2.22e-01 2.94e-01
GLYCOSPHINGOLIPID METABOLISM 38 1.86e-02 2.21e-01 7.27e-02
SHC1 EVENTS IN EGFR SIGNALING 11 2.06e-01 2.20e-01 3.82e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 2.28e-01 2.20e-01 4.06e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 1.88e-01 2.20e-01 3.65e-01
INNATE IMMUNE SYSTEM 772 7.24e-25 2.19e-01 2.11e-22
THE NLRP3 INFLAMMASOME 15 1.43e-01 2.18e-01 3.03e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 9.96e-02 2.18e-01 2.37e-01
COSTIMULATION BY THE CD28 FAMILY 48 9.05e-03 2.18e-01 4.11e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 92 3.10e-04 2.18e-01 2.76e-03
PARASITE INFECTION 55 5.30e-03 2.17e-01 2.64e-02
SYNDECAN INTERACTIONS 26 5.55e-02 2.17e-01 1.56e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 3.12e-02 2.17e-01 1.02e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 1.76e-01 2.17e-01 3.52e-01
SIGNALING BY FGFR2 IN DISEASE 36 2.45e-02 2.17e-01 8.76e-02
COHESIN LOADING ONTO CHROMATIN 10 2.36e-01 2.16e-01 4.16e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.36e-01 2.16e-01 4.16e-01
FCERI MEDIATED MAPK ACTIVATION 28 5.02e-02 2.14e-01 1.44e-01
SIGNALING BY FGFR2 IIIA TM 19 1.07e-01 2.13e-01 2.48e-01
INTRAFLAGELLAR TRANSPORT 49 9.76e-03 -2.13e-01 4.35e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 1.18e-01 2.13e-01 2.65e-01
BILE ACID AND BILE SALT METABOLISM 24 7.14e-02 2.13e-01 1.90e-01
SMOOTH MUSCLE CONTRACTION 33 3.49e-02 2.12e-01 1.11e-01
CD209 DC SIGN SIGNALING 18 1.19e-01 2.12e-01 2.68e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 2.04e-01 2.12e-01 3.80e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 1.01e-01 2.12e-01 2.39e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 2.25e-01 2.11e-01 4.04e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 2.45e-02 2.11e-01 8.76e-02
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 1.44e-01 2.11e-01 3.05e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 140 1.86e-05 2.10e-01 2.68e-04
IRS MEDIATED SIGNALLING 37 2.77e-02 2.09e-01 9.49e-02
CYTOSOLIC TRNA AMINOACYLATION 24 7.68e-02 2.09e-01 1.98e-01
PERK REGULATES GENE EXPRESSION 28 5.67e-02 2.08e-01 1.58e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.13e-01 2.08e-01 3.89e-01
MRNA SPLICING MINOR PATHWAY 52 1.02e-02 2.06e-01 4.49e-02
FOXO MEDIATED TRANSCRIPTION 59 6.50e-03 2.05e-01 3.11e-02
ERKS ARE INACTIVATED 13 2.02e-01 2.04e-01 3.79e-01
REGULATED PROTEOLYSIS OF P75NTR 12 2.22e-01 2.04e-01 4.00e-01
SIGNALING BY EGFR IN CANCER 22 9.84e-02 2.04e-01 2.35e-01
REGULATION OF BACH1 ACTIVITY 11 2.44e-01 2.03e-01 4.21e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 5.89e-02 2.03e-01 1.62e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 2.01e-02 2.03e-01 7.56e-02
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 1.77e-01 -2.02e-01 3.52e-01
OPIOID SIGNALLING 86 1.26e-03 2.01e-01 8.43e-03
PLASMA LIPOPROTEIN CLEARANCE 26 7.59e-02 2.01e-01 1.97e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 1.65e-03 2.01e-01 1.08e-02
FCGR3A MEDIATED IL10 SYNTHESIS 32 4.92e-02 2.01e-01 1.42e-01
SIGNALING BY WNT IN CANCER 31 5.33e-02 2.01e-01 1.50e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 26 7.69e-02 2.00e-01 1.98e-01
REGULATED NECROSIS 45 2.01e-02 2.00e-01 7.56e-02
DNA REPLICATION 121 1.48e-04 2.00e-01 1.42e-03
PCP CE PATHWAY 90 1.08e-03 1.99e-01 7.64e-03
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 9.82e-02 1.99e-01 2.35e-01
ACTIVATION OF SMO 16 1.68e-01 -1.99e-01 3.38e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 1.33e-01 1.99e-01 2.88e-01
RHOH GTPASE CYCLE 37 3.63e-02 1.99e-01 1.13e-01
KERATAN SULFATE BIOSYNTHESIS 24 9.25e-02 1.98e-01 2.24e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 2.55e-01 1.98e-01 4.32e-01
DAP12 SIGNALING 24 9.30e-02 1.98e-01 2.25e-01
REGULATION OF SIGNALING BY CBL 22 1.08e-01 1.98e-01 2.48e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 1.58e-01 1.98e-01 3.24e-01
PURINE SALVAGE 12 2.36e-01 1.97e-01 4.16e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 2.18e-01 -1.97e-01 3.95e-01
SIGNALING BY ERYTHROPOIETIN 24 9.47e-02 1.97e-01 2.29e-01
RHO GTPASES ACTIVATE PKNS 47 1.99e-02 1.96e-01 7.53e-02
TRANSCRIPTIONAL REGULATION BY RUNX2 110 3.95e-04 1.96e-01 3.34e-03
HEDGEHOG ON STATE 82 2.25e-03 1.95e-01 1.37e-02
SPRY REGULATION OF FGF SIGNALING 16 1.77e-01 1.95e-01 3.52e-01
INFECTIOUS DISEASE 727 1.02e-18 1.93e-01 1.70e-16
EPHB MEDIATED FORWARD SIGNALING 42 3.06e-02 1.93e-01 1.02e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 42 3.07e-02 1.93e-01 1.02e-01
PROLACTIN RECEPTOR SIGNALING 11 2.69e-01 1.93e-01 4.46e-01
GAP JUNCTION ASSEMBLY 21 1.27e-01 1.92e-01 2.80e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 1.05e-01 1.91e-01 2.46e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 3.04e-02 -1.91e-01 1.01e-01
SIGNALING BY NTRK3 TRKC 17 1.76e-01 -1.89e-01 3.52e-01
HEME SIGNALING 44 2.98e-02 -1.89e-01 9.97e-02
UCH PROTEINASES 88 2.16e-03 1.89e-01 1.33e-02
TRANSLESION SYNTHESIS BY POLH 19 1.53e-01 1.89e-01 3.18e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 2.05e-01 1.89e-01 3.81e-01
SARS COV INFECTIONS 139 1.28e-04 1.88e-01 1.23e-03
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 88 2.37e-03 1.88e-01 1.43e-02
PHASE 2 PLATEAU PHASE 13 2.42e-01 -1.87e-01 4.18e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 2.82e-01 -1.87e-01 4.60e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 10 3.06e-01 -1.87e-01 4.83e-01
SIGNALING BY HIPPO 20 1.48e-01 1.87e-01 3.10e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 3.12e-03 1.87e-01 1.77e-02
PROGRAMMED CELL DEATH 185 1.29e-05 1.86e-01 2.03e-04
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.86e-01 1.86e-01 4.64e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 2.47e-01 1.86e-01 4.23e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 1.43e-01 1.85e-01 3.03e-01
VOLTAGE GATED POTASSIUM CHANNELS 40 4.36e-02 -1.84e-01 1.31e-01
ACTIVATION OF RAC1 13 2.50e-01 1.84e-01 4.28e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 77 5.36e-03 1.84e-01 2.65e-02
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 4.22e-02 1.83e-01 1.27e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 2.35e-01 -1.83e-01 4.16e-01
APOPTOSIS 163 5.61e-05 1.83e-01 6.65e-04
LAGGING STRAND SYNTHESIS 20 1.57e-01 1.83e-01 3.23e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 11 2.96e-01 1.82e-01 4.73e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.49e-01 -1.82e-01 3.12e-01
RESOLUTION OF D LOOP STRUCTURES 30 8.49e-02 -1.82e-01 2.11e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 13 2.57e-01 1.82e-01 4.34e-01
RHOBTB GTPASE CYCLE 35 6.31e-02 1.82e-01 1.72e-01
KERATAN SULFATE KERATIN METABOLISM 30 8.53e-02 1.82e-01 2.11e-01
GENERATION OF SECOND MESSENGER MOLECULES 20 1.60e-01 1.81e-01 3.27e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 2.59e-01 1.81e-01 4.36e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 1.61e-01 -1.81e-01 3.28e-01
INTEGRIN SIGNALING 24 1.25e-01 1.81e-01 2.78e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 2.75e-02 -1.80e-01 9.45e-02
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.74e-01 1.80e-01 3.49e-01
CGMP EFFECTS 15 2.27e-01 -1.80e-01 4.06e-01
PRE NOTCH PROCESSING IN GOLGI 17 1.99e-01 1.80e-01 3.78e-01
RAP1 SIGNALLING 15 2.28e-01 1.80e-01 4.06e-01
INTERLEUKIN 7 SIGNALING 20 1.65e-01 -1.79e-01 3.33e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 2.01e-01 1.79e-01 3.79e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 1.15e-01 1.79e-01 2.61e-01
HIV INFECTION 221 4.93e-06 1.79e-01 9.19e-05
SEPARATION OF SISTER CHROMATIDS 164 8.64e-05 1.78e-01 9.16e-04
MUCOPOLYSACCHARIDOSES 11 3.07e-01 1.78e-01 4.83e-01
KERATAN SULFATE DEGRADATION 11 3.09e-01 1.77e-01 4.85e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 62 1.59e-02 1.77e-01 6.48e-02
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.94e-01 -1.77e-01 3.70e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 4.74e-02 1.77e-01 1.39e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 3.31e-03 1.76e-01 1.82e-02
MITOTIC METAPHASE AND ANAPHASE 204 1.45e-05 1.76e-01 2.23e-04
INTERLEUKIN 10 SIGNALING 17 2.09e-01 1.76e-01 3.84e-01
SYNTHESIS OF PC 25 1.28e-01 1.76e-01 2.81e-01
GP1B IX V ACTIVATION SIGNALLING 11 3.13e-01 -1.76e-01 4.88e-01
HEME BIOSYNTHESIS 13 2.73e-01 1.76e-01 4.51e-01
G ALPHA Z SIGNALLING EVENTS 45 4.16e-02 1.76e-01 1.26e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 3.36e-01 -1.76e-01 5.13e-01
SIGNALING BY INTERLEUKINS 346 2.19e-08 1.75e-01 9.13e-07
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 1.38e-01 1.75e-01 2.96e-01
UB SPECIFIC PROCESSING PROTEASES 166 1.14e-04 1.74e-01 1.15e-03
REGULATION OF FZD BY UBIQUITINATION 19 1.91e-01 1.73e-01 3.68e-01
RHO GTPASES ACTIVATE ROCKS 19 1.92e-01 1.73e-01 3.68e-01
TELOMERE EXTENSION BY TELOMERASE 23 1.51e-01 -1.73e-01 3.16e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 3.01e-01 1.72e-01 4.79e-01
COLLAGEN FORMATION 77 9.34e-03 -1.71e-01 4.19e-02
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 1.30e-01 1.71e-01 2.85e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 3.25e-01 1.71e-01 5.03e-01
RHOQ GTPASE CYCLE 58 2.49e-02 1.70e-01 8.76e-02
G ALPHA I SIGNALLING EVENTS 193 4.68e-05 1.70e-01 5.75e-04
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 2.71e-01 -1.70e-01 4.49e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 138 5.96e-04 1.69e-01 4.86e-03
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 4.18e-03 -1.69e-01 2.19e-02
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.29e-01 1.69e-01 2.82e-01
HSF1 ACTIVATION 26 1.39e-01 1.68e-01 2.96e-01
HDMS DEMETHYLATE HISTONES 27 1.31e-01 -1.68e-01 2.86e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.61e-02 1.67e-01 9.04e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 49 4.43e-02 -1.66e-01 1.33e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 3.41e-01 1.66e-01 5.17e-01
SIGNALING BY FGFR1 IN DISEASE 32 1.06e-01 1.65e-01 2.46e-01
RND3 GTPASE CYCLE 38 7.87e-02 -1.65e-01 2.00e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 9.83e-02 1.64e-01 2.35e-01
SIGNALING BY VEGF 102 4.39e-03 1.63e-01 2.28e-02
FORMATION OF INCISION COMPLEX IN GG NER 43 6.40e-02 1.63e-01 1.74e-01
AURKA ACTIVATION BY TPX2 71 1.74e-02 -1.63e-01 6.90e-02
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 1.29e-01 1.63e-01 2.82e-01
G2 M CHECKPOINTS 133 1.19e-03 1.63e-01 8.16e-03
DSCAM INTERACTIONS 11 3.50e-01 -1.63e-01 5.25e-01
POLYMERASE SWITCHING 14 2.93e-01 1.62e-01 4.71e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 59 3.10e-02 -1.62e-01 1.02e-01
AMYLOID FIBER FORMATION 56 3.56e-02 1.62e-01 1.11e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 1.98e-04 1.62e-01 1.83e-03
TOLL LIKE RECEPTOR CASCADES 137 1.05e-03 1.62e-01 7.51e-03
SIGNALING BY FGFR IN DISEASE 55 3.80e-02 1.62e-01 1.17e-01
RUNX3 REGULATES NOTCH SIGNALING 13 3.13e-01 -1.62e-01 4.88e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 2.80e-01 1.61e-01 4.59e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 2.01e-01 1.61e-01 3.79e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 1.47e-01 1.61e-01 3.10e-01
METABOLISM OF CARBOHYDRATES 258 8.87e-06 1.61e-01 1.48e-04
REPRESSION OF WNT TARGET GENES 14 2.98e-01 1.61e-01 4.74e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 2.39e-01 1.60e-01 4.17e-01
AUTOPHAGY 138 1.17e-03 1.60e-01 8.10e-03
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 5.27e-02 1.60e-01 1.49e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 6.80e-03 1.60e-01 3.21e-02
LATE ENDOSOMAL MICROAUTOPHAGY 31 1.25e-01 1.59e-01 2.78e-01
SELECTIVE AUTOPHAGY 72 1.99e-02 1.59e-01 7.53e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 2.08e-01 1.59e-01 3.84e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 2.88e-01 1.58e-01 4.67e-01
METAL ION SLC TRANSPORTERS 24 1.79e-01 1.58e-01 3.55e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 597 5.41e-11 1.58e-01 3.16e-09
PEPTIDE HORMONE METABOLISM 58 3.80e-02 1.58e-01 1.17e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 2.11e-01 1.58e-01 3.87e-01
MET ACTIVATES PTK2 SIGNALING 29 1.42e-01 -1.58e-01 3.03e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 2.75e-01 -1.57e-01 4.53e-01
TRANSLESION SYNTHESIS BY POLK 17 2.61e-01 1.57e-01 4.39e-01
CHROMATIN MODIFYING ENZYMES 217 6.68e-05 -1.57e-01 7.35e-04
HDACS DEACETYLATE HISTONES 45 6.82e-02 -1.57e-01 1.83e-01
RHO GTPASES ACTIVATE PAKS 21 2.13e-01 1.57e-01 3.89e-01
BASIGIN INTERACTIONS 22 2.04e-01 1.57e-01 3.80e-01
NUCLEOBASE CATABOLISM 31 1.32e-01 1.56e-01 2.88e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.30e-01 1.56e-01 5.08e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 1.29e-02 -1.56e-01 5.42e-02
P75NTR REGULATES AXONOGENESIS 10 3.95e-01 1.55e-01 5.63e-01
SIGNALING BY ERBB4 57 4.27e-02 1.55e-01 1.29e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 1.79e-02 -1.55e-01 7.04e-02
MTORC1 MEDIATED SIGNALLING 24 1.89e-01 1.55e-01 3.66e-01
INTERLEUKIN 37 SIGNALING 19 2.45e-01 1.54e-01 4.22e-01
RHOG GTPASE CYCLE 73 2.34e-02 1.53e-01 8.50e-02
FERTILIZATION 12 3.58e-01 -1.53e-01 5.29e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 138 1.91e-03 1.53e-01 1.22e-02
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 3.58e-01 1.53e-01 5.29e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 178 4.33e-04 1.53e-01 3.64e-03
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 2.48e-02 1.53e-01 8.76e-02
NRAGE SIGNALS DEATH THROUGH JNK 56 4.78e-02 -1.53e-01 1.39e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 13 3.40e-01 -1.53e-01 5.17e-01
NEDDYLATION 216 1.12e-04 1.53e-01 1.13e-03
ACYL CHAIN REMODELLING OF PE 16 2.91e-01 1.52e-01 4.71e-01
PROTEIN FOLDING 88 1.38e-02 1.52e-01 5.72e-02
SIGNALING BY WNT 266 2.10e-05 1.52e-01 2.96e-04
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.98e-01 -1.52e-01 3.76e-01
PLATELET AGGREGATION PLUG FORMATION 33 1.34e-01 1.51e-01 2.90e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 2.82e-01 -1.51e-01 4.60e-01
DISEASES OF DNA REPAIR 11 3.87e-01 -1.51e-01 5.57e-01
STIMULI SENSING CHANNELS 74 2.53e-02 -1.50e-01 8.87e-02
SYNTHESIS OF PE 12 3.67e-01 -1.50e-01 5.39e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 3.30e-01 -1.50e-01 5.08e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 3.69e-01 -1.50e-01 5.40e-01
PECAM1 INTERACTIONS 12 3.70e-01 1.49e-01 5.40e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 3.70e-01 1.49e-01 5.40e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 7.40e-02 1.49e-01 1.94e-01
REGULATION OF IFNG SIGNALING 13 3.52e-01 1.49e-01 5.28e-01
SIGNALING BY PDGFR IN DISEASE 20 2.51e-01 1.48e-01 4.28e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 3.05e-01 1.48e-01 4.82e-01
TP53 REGULATES METABOLIC GENES 84 1.89e-02 1.48e-01 7.31e-02
METABOLISM OF NUCLEOTIDES 91 1.47e-02 1.48e-01 6.03e-02
COLLAGEN DEGRADATION 49 7.43e-02 -1.47e-01 1.94e-01
SIGNALING BY ERBB2 48 8.01e-02 1.46e-01 2.02e-01
NEGATIVE REGULATION OF MAPK PATHWAY 43 9.86e-02 1.46e-01 2.35e-01
DISEASES OF IMMUNE SYSTEM 23 2.28e-01 1.45e-01 4.06e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 3.48e-01 1.45e-01 5.24e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 3.52e-01 1.44e-01 5.27e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 1.81e-01 -1.44e-01 3.58e-01
SIGNALING BY PTK6 50 8.01e-02 1.43e-01 2.02e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 3.73e-01 -1.43e-01 5.43e-01
SIALIC ACID METABOLISM 32 1.63e-01 1.42e-01 3.30e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 2.96e-01 -1.42e-01 4.73e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 2.96e-01 -1.42e-01 4.73e-01
UNFOLDED PROTEIN RESPONSE UPR 85 2.37e-02 1.42e-01 8.55e-02
OLFACTORY SIGNALING PATHWAY 23 2.40e-01 1.42e-01 4.18e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 2.51e-01 1.42e-01 4.28e-01
LONG TERM POTENTIATION 23 2.42e-01 -1.41e-01 4.18e-01
SIGNALING BY FGFR2 64 5.11e-02 1.41e-01 1.45e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 28 1.97e-01 1.41e-01 3.76e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 4.00e-01 1.40e-01 5.68e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 1.91e-01 -1.40e-01 3.68e-01
LEISHMANIA INFECTION 193 7.88e-04 1.40e-01 5.82e-03
TRANSCRIPTIONAL REGULATION BY VENTX 35 1.52e-01 -1.40e-01 3.16e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 1.92e-01 1.40e-01 3.68e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 1.36e-01 -1.40e-01 2.94e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 3.35e-01 1.39e-01 5.12e-01
IRAK1 RECRUITS IKK COMPLEX 14 3.67e-01 1.39e-01 5.39e-01
GPCR LIGAND BINDING 259 1.18e-04 1.39e-01 1.16e-03
RA BIOSYNTHESIS PATHWAY 12 4.04e-01 1.39e-01 5.72e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 2.39e-01 1.39e-01 4.17e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 2.39e-01 1.39e-01 4.17e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 3.22e-01 -1.39e-01 4.99e-01
SURFACTANT METABOLISM 16 3.37e-01 1.39e-01 5.14e-01
NGF STIMULATED TRANSCRIPTION 37 1.46e-01 1.38e-01 3.08e-01
INTERLEUKIN 35 SIGNALLING 10 4.50e-01 1.38e-01 6.12e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 17 3.25e-01 -1.38e-01 5.03e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 2.75e-01 1.38e-01 4.53e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.53e-01 -1.37e-01 6.15e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 1.87e-01 -1.37e-01 3.65e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 8.55e-02 1.37e-01 2.11e-01
CD28 CO STIMULATION 29 2.04e-01 1.36e-01 3.80e-01
HEMOSTASIS 471 4.75e-07 1.36e-01 1.39e-05
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 3.80e-01 1.36e-01 5.50e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 6.81e-02 -1.35e-01 1.83e-01
HS GAG BIOSYNTHESIS 29 2.08e-01 1.35e-01 3.84e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 2.53e-01 1.35e-01 4.29e-01
MET ACTIVATES RAS SIGNALING 10 4.61e-01 1.35e-01 6.20e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 2.44e-01 1.35e-01 4.21e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 4.20e-01 1.35e-01 5.84e-01
CELL CYCLE CHECKPOINTS 241 3.33e-04 1.34e-01 2.94e-03
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.18e-01 -1.34e-01 3.95e-01
ASPARAGINE N LINKED GLYCOSYLATION 283 1.09e-04 1.34e-01 1.11e-03
SIGNALING BY EGFR 47 1.12e-01 1.34e-01 2.56e-01
DNA DAMAGE RECOGNITION IN GG NER 38 1.54e-01 1.34e-01 3.18e-01
TRANSCRIPTIONAL REGULATION BY MECP2 60 7.33e-02 -1.34e-01 1.93e-01
DNA STRAND ELONGATION 32 1.90e-01 1.34e-01 3.68e-01
TIGHT JUNCTION INTERACTIONS 18 3.26e-01 1.34e-01 5.03e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 4.43e-01 1.34e-01 6.06e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 34 1.78e-01 1.33e-01 3.54e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 3.66e-02 1.33e-01 1.14e-01
ADAPTIVE IMMUNE SYSTEM 594 3.69e-08 1.33e-01 1.49e-06
SIGNALING BY FGFR 74 4.96e-02 1.32e-01 1.43e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 3.93e-01 1.32e-01 5.62e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.65e-01 1.32e-01 4.42e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 1.91e-01 1.31e-01 3.68e-01
RND2 GTPASE CYCLE 38 1.62e-01 -1.31e-01 3.28e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 9.20e-03 1.31e-01 4.14e-02
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 1.38e-01 1.31e-01 2.96e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 105 2.10e-02 -1.30e-01 7.79e-02
HEDGEHOG OFF STATE 106 2.05e-02 1.30e-01 7.67e-02
CARGO CONCENTRATION IN THE ER 31 2.11e-01 1.30e-01 3.87e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 93 3.12e-02 1.29e-01 1.02e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.58e-01 -1.29e-01 3.24e-01
MATURATION OF NUCLEOPROTEIN 10 4.82e-01 -1.29e-01 6.37e-01
AMINE LIGAND BINDING RECEPTORS 31 2.16e-01 1.28e-01 3.92e-01
DEFECTS IN COBALAMIN B12 METABOLISM 12 4.41e-01 1.28e-01 6.05e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 3.91e-01 1.28e-01 5.60e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 4.85e-01 -1.27e-01 6.40e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 2.28e-01 1.27e-01 4.06e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 3.02e-01 1.27e-01 4.80e-01
REGULATION OF IFNA SIGNALING 12 4.46e-01 -1.27e-01 6.09e-01
ACYL CHAIN REMODELLING OF PG 10 4.88e-01 1.27e-01 6.43e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 6.93e-02 1.27e-01 1.85e-01
ELASTIC FIBRE FORMATION 36 1.89e-01 1.27e-01 3.66e-01
MRNA SPLICING 188 2.82e-03 1.26e-01 1.64e-02
DEUBIQUITINATION 240 7.56e-04 1.26e-01 5.77e-03
SIGNALING BY LEPTIN 10 4.89e-01 -1.26e-01 6.43e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 114 1.99e-02 1.26e-01 7.53e-02
ERBB2 ACTIVATES PTK6 SIGNALING 11 4.69e-01 -1.26e-01 6.26e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 1.63e-01 1.26e-01 3.30e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 341 6.63e-05 1.26e-01 7.35e-04
PROCESSING OF SMDT1 16 3.84e-01 1.26e-01 5.55e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 90 3.96e-02 1.26e-01 1.22e-01
RHO GTPASE EFFECTORS 247 6.98e-04 1.25e-01 5.47e-03
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.46e-01 1.25e-01 3.08e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.61e-02 -1.25e-01 1.37e-01
OTHER SEMAPHORIN INTERACTIONS 19 3.45e-01 -1.25e-01 5.23e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 2.29e-01 -1.25e-01 4.07e-01
RHOV GTPASE CYCLE 32 2.23e-01 -1.25e-01 4.00e-01
AMINO ACIDS REGULATE MTORC1 51 1.25e-01 1.24e-01 2.78e-01
O LINKED GLYCOSYLATION 85 4.80e-02 -1.24e-01 1.39e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 2.33e-01 1.24e-01 4.13e-01
MITOTIC TELOPHASE CYTOKINESIS 13 4.41e-01 1.23e-01 6.05e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 3.54e-01 -1.23e-01 5.29e-01
SIGNALING BY MET 75 6.63e-02 1.23e-01 1.79e-01
G ALPHA Q SIGNALLING EVENTS 154 8.95e-03 1.22e-01 4.08e-02
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.63e-01 1.22e-01 4.41e-01
HDR THROUGH MMEJ ALT NHEJ 10 5.04e-01 -1.22e-01 6.57e-01
PEPTIDE LIGAND BINDING RECEPTORS 101 3.47e-02 1.22e-01 1.11e-01
RHOBTB1 GTPASE CYCLE 23 3.13e-01 1.22e-01 4.88e-01
SIGNALING BY KIT IN DISEASE 20 3.47e-01 1.22e-01 5.23e-01
SIGNAL TRANSDUCTION BY L1 21 3.35e-01 1.22e-01 5.12e-01
TRAFFICKING OF AMPA RECEPTORS 31 2.42e-01 -1.22e-01 4.18e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 1.07e-01 1.22e-01 2.47e-01
CILIUM ASSEMBLY 189 4.14e-03 -1.21e-01 2.17e-02
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 37 2.03e-01 1.21e-01 3.80e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.04e-01 -1.21e-01 3.81e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 2.11e-01 1.20e-01 3.87e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.57e-01 -1.19e-01 5.29e-01
METABOLISM OF LIPIDS 608 6.27e-07 1.19e-01 1.78e-05
RORA ACTIVATES GENE EXPRESSION 18 3.84e-01 -1.18e-01 5.55e-01
INTERLEUKIN 27 SIGNALING 10 5.18e-01 1.18e-01 6.69e-01
SIGNALING BY NUCLEAR RECEPTORS 219 2.76e-03 1.18e-01 1.61e-02
PLATELET HOMEOSTASIS 76 7.80e-02 1.17e-01 1.99e-01
RHOJ GTPASE CYCLE 54 1.38e-01 1.17e-01 2.96e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 4.35e-01 -1.16e-01 5.99e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 34 2.41e-01 -1.16e-01 4.18e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 3.35e-01 -1.16e-01 5.12e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 537 4.50e-06 1.16e-01 8.91e-05
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 6.18e-02 1.16e-01 1.68e-01
RNA POLYMERASE III TRANSCRIPTION 41 2.01e-01 -1.15e-01 3.79e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 4.57e-01 1.15e-01 6.16e-01
COPII MEDIATED VESICLE TRANSPORT 66 1.07e-01 1.15e-01 2.48e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 20 3.75e-01 1.15e-01 5.45e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 1.21e-01 1.14e-01 2.71e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 2.07e-01 -1.14e-01 3.82e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 4.95e-01 1.14e-01 6.49e-01
SIGNALING BY NODAL 15 4.45e-01 1.14e-01 6.08e-01
CELLULAR HEXOSE TRANSPORT 11 5.14e-01 -1.14e-01 6.65e-01
DUAL INCISION IN GG NER 40 2.15e-01 1.13e-01 3.91e-01
TBC RABGAPS 43 2.00e-01 1.13e-01 3.78e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 2.94e-01 1.13e-01 4.71e-01
METABOLISM OF RNA 643 1.30e-06 1.12e-01 3.15e-05
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 2.58e-01 -1.12e-01 4.35e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 5.02e-01 1.12e-01 6.54e-01
INTEGRATION OF ENERGY METABOLISM 98 5.57e-02 1.12e-01 1.56e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 3.77e-01 -1.11e-01 5.47e-01
EGFR DOWNREGULATION 28 3.09e-01 1.11e-01 4.85e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 9.21e-02 1.11e-01 2.24e-01
MAPK FAMILY SIGNALING CASCADES 287 1.23e-03 1.11e-01 8.37e-03
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 3.78e-01 1.11e-01 5.48e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 3.29e-01 -1.11e-01 5.07e-01
SYNTHESIS OF PA 29 3.03e-01 1.10e-01 4.81e-01
RESOLUTION OF SISTER CHROMATID COHESION 100 5.71e-02 1.10e-01 1.58e-01
RND1 GTPASE CYCLE 38 2.41e-01 -1.10e-01 4.18e-01
EPH EPHRIN SIGNALING 90 7.19e-02 1.10e-01 1.90e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 2.35e-01 1.10e-01 4.16e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 1.84e-01 1.10e-01 3.61e-01
NEGATIVE REGULATION OF FLT3 14 4.79e-01 -1.09e-01 6.36e-01
BIOTIN TRANSPORT AND METABOLISM 11 5.30e-01 1.09e-01 6.78e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 1.35e-01 1.09e-01 2.91e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 4.24e-01 -1.09e-01 5.87e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 31 2.94e-01 1.09e-01 4.72e-01
SIGNALING BY ERBB2 IN CANCER 25 3.47e-01 1.09e-01 5.23e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 2.88e-01 1.09e-01 4.67e-01
ASSEMBLY OF THE HIV VIRION 16 4.54e-01 1.08e-01 6.15e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 3.23e-01 1.08e-01 5.00e-01
ZINC TRANSPORTERS 15 4.69e-01 1.08e-01 6.26e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.55e-01 1.08e-01 6.97e-01
TRNA PROCESSING 105 5.64e-02 -1.08e-01 1.57e-01
CHOLESTEROL BIOSYNTHESIS 24 3.61e-01 1.08e-01 5.32e-01
GLYCOSAMINOGLYCAN METABOLISM 114 4.69e-02 1.08e-01 1.38e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 38 2.53e-01 1.07e-01 4.29e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.89e-01 1.07e-01 6.43e-01
PLATELET CALCIUM HOMEOSTASIS 25 3.57e-01 -1.07e-01 5.29e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 7.63e-02 1.06e-01 1.97e-01
TRANSPORT OF SMALL MOLECULES 566 1.76e-05 1.06e-01 2.60e-04
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 5.44e-01 1.06e-01 6.89e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 4.01e-01 1.06e-01 5.69e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 1.11e-01 1.06e-01 2.54e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 2.81e-01 -1.05e-01 4.60e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 3.63e-01 1.05e-01 5.35e-01
FANCONI ANEMIA PATHWAY 36 2.76e-01 -1.05e-01 4.54e-01
CARNITINE METABOLISM 14 4.97e-01 1.05e-01 6.50e-01
GLUCOSE METABOLISM 80 1.05e-01 1.05e-01 2.46e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 43 2.37e-01 -1.04e-01 4.16e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 10 5.68e-01 1.04e-01 7.08e-01
DUAL INCISION IN TC NER 64 1.54e-01 1.03e-01 3.19e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 2.15e-01 1.02e-01 3.91e-01
MICRORNA MIRNA BIOGENESIS 24 3.86e-01 -1.02e-01 5.56e-01
RECYCLING PATHWAY OF L1 40 2.66e-01 1.02e-01 4.44e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 3.39e-01 -1.01e-01 5.15e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.06e-01 1.01e-01 3.81e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 3.85e-01 -1.00e-01 5.55e-01
NUCLEOTIDE EXCISION REPAIR 109 7.05e-02 1.00e-01 1.88e-01
FORMATION OF THE CORNIFIED ENVELOPE 28 3.58e-01 -1.00e-01 5.29e-01
KERATINIZATION 28 3.58e-01 -1.00e-01 5.29e-01
ESR MEDIATED SIGNALING 163 2.81e-02 9.98e-02 9.54e-02
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 59 1.86e-01 -9.96e-02 3.64e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 1.02e-01 9.94e-02 2.39e-01
ERK MAPK TARGETS 22 4.24e-01 9.85e-02 5.87e-01
HIV TRANSCRIPTION INITIATION 45 2.56e-01 9.79e-02 4.34e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 5.58e-01 9.76e-02 6.99e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 5.94e-01 9.75e-02 7.26e-01
MITOTIC SPINDLE CHECKPOINT 96 9.91e-02 9.75e-02 2.36e-01
POTENTIAL THERAPEUTICS FOR SARS 76 1.42e-01 9.74e-02 3.03e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 4.20e-01 9.72e-02 5.84e-01
REGULATION OF INSULIN SECRETION 71 1.58e-01 9.69e-02 3.25e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 2.66e-01 9.69e-02 4.44e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 5.46e-01 9.68e-02 6.91e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 284 5.17e-03 9.66e-02 2.59e-02
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 1.26e-01 -9.66e-02 2.78e-01
METABOLISM OF STEROIDS 111 8.05e-02 9.61e-02 2.02e-01
RAC2 GTPASE CYCLE 86 1.25e-01 9.56e-02 2.78e-01
INSULIN PROCESSING 24 4.23e-01 9.45e-02 5.87e-01
SIGNALING BY HEDGEHOG 141 5.31e-02 9.45e-02 1.50e-01
INTRINSIC PATHWAY FOR APOPTOSIS 50 2.52e-01 9.36e-02 4.29e-01
STRIATED MUSCLE CONTRACTION 26 4.10e-01 -9.33e-02 5.77e-01
RHO GTPASES ACTIVATE FORMINS 118 8.05e-02 9.32e-02 2.02e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 1.26e-01 9.24e-02 2.78e-01
NEUROTRANSMITTER RELEASE CYCLE 48 2.69e-01 9.23e-02 4.46e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1206 9.32e-08 9.21e-02 3.26e-06
EFFECTS OF PIP2 HYDROLYSIS 27 4.08e-01 -9.21e-02 5.75e-01
G PROTEIN MEDIATED EVENTS 52 2.52e-01 9.19e-02 4.29e-01
NERVOUS SYSTEM DEVELOPMENT 546 2.53e-04 9.19e-02 2.29e-03
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 365 2.63e-03 9.19e-02 1.54e-02
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 1.98e-01 -9.17e-02 3.76e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 3.10e-01 9.17e-02 4.85e-01
RAB REGULATION OF TRAFFICKING 118 8.56e-02 9.17e-02 2.11e-01
NUCLEAR IMPORT OF REV PROTEIN 32 3.70e-01 -9.17e-02 5.40e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 2.09e-01 9.15e-02 3.84e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 5.27e-01 -9.14e-02 6.78e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 45 2.94e-01 9.05e-02 4.71e-01
CHONDROITIN SULFATE BIOSYNTHESIS 19 4.95e-01 9.04e-02 6.49e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 4.08e-01 -9.03e-02 5.76e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 5.77e-01 8.95e-02 7.15e-01
GENE SILENCING BY RNA 83 1.60e-01 -8.93e-02 3.27e-01
NETRIN 1 SIGNALING 49 2.81e-01 -8.91e-02 4.60e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.87e-02 8.88e-02 7.28e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 6.10e-01 -8.88e-02 7.40e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 5.15e-01 8.87e-02 6.66e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 5.80e-01 -8.87e-02 7.18e-01
APOPTOTIC EXECUTION PHASE 46 3.00e-01 8.84e-02 4.78e-01
SIGNALING BY GPCR 476 1.01e-03 8.83e-02 7.25e-03
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 169 4.80e-02 8.83e-02 1.39e-01
P75NTR SIGNALS VIA NF KB 16 5.41e-01 8.82e-02 6.89e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 5.29e-01 -8.82e-02 6.78e-01
HS GAG DEGRADATION 20 4.96e-01 -8.79e-02 6.49e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 5.84e-01 8.78e-02 7.19e-01
MEMBRANE TRAFFICKING 579 3.95e-04 8.65e-02 3.34e-03
HCMV EARLY EVENTS 79 1.84e-01 -8.65e-02 3.61e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 4.73e-01 8.65e-02 6.30e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 11 6.20e-01 8.65e-02 7.46e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 5.06e-01 8.59e-02 6.58e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 5.18e-01 8.56e-02 6.69e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 2.64e-01 -8.55e-02 4.42e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 5.69e-01 -8.48e-02 7.09e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 3.05e-01 8.47e-02 4.82e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 5.46e-01 -8.46e-02 6.91e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 463 2.10e-03 8.37e-02 1.29e-02
OXIDATIVE STRESS INDUCED SENESCENCE 78 2.02e-01 -8.36e-02 3.79e-01
LYSINE CATABOLISM 11 6.32e-01 8.33e-02 7.54e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 6.03e-01 8.33e-02 7.36e-01
PTEN REGULATION 134 9.64e-02 8.33e-02 2.32e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 5.42e-01 -8.31e-02 6.89e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 2.71e-01 -8.29e-02 4.49e-01
SIGNALING BY NTRKS 131 1.03e-01 8.25e-02 2.42e-01
HATS ACETYLATE HISTONES 91 1.75e-01 -8.23e-02 3.50e-01
NUCLEAR ENVELOPE NE REASSEMBLY 63 2.61e-01 8.20e-02 4.39e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 5.84e-01 -8.17e-02 7.19e-01
MYOGENESIS 25 4.79e-01 -8.17e-02 6.36e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 4.55e-01 8.17e-02 6.15e-01
HIV LIFE CYCLE 143 9.23e-02 8.16e-02 2.24e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 43 3.55e-01 -8.16e-02 5.29e-01
PRE NOTCH EXPRESSION AND PROCESSING 63 2.64e-01 -8.13e-02 4.42e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 13 6.12e-01 8.13e-02 7.41e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 5.40e-01 8.12e-02 6.89e-01
VESICLE MEDIATED TRANSPORT 607 6.75e-04 8.12e-02 5.32e-03
CONDENSATION OF PROPHASE CHROMOSOMES 27 4.66e-01 8.12e-02 6.23e-01
SODIUM CALCIUM EXCHANGERS 10 6.66e-01 7.89e-02 7.84e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 3.18e-01 -7.86e-02 4.94e-01
TNF SIGNALING 43 3.75e-01 7.82e-02 5.45e-01
ECM PROTEOGLYCANS 64 2.81e-01 -7.80e-02 4.60e-01
METABOLISM OF VITAMINS AND COFACTORS 148 1.03e-01 7.77e-02 2.41e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 1.66e-01 -7.75e-02 3.35e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 3.55e-01 7.72e-02 5.29e-01
MTOR SIGNALLING 40 3.99e-01 7.71e-02 5.67e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 281 2.84e-02 7.61e-02 9.60e-02
SIGNALLING TO ERKS 34 4.46e-01 7.56e-02 6.08e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 3.93e-01 7.54e-02 5.61e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 5.80e-01 7.53e-02 7.18e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 4.56e-01 7.50e-02 6.16e-01
M PHASE 336 1.91e-02 7.46e-02 7.32e-02
POLO LIKE KINASE MEDIATED EVENTS 13 6.44e-01 7.40e-02 7.64e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 5.42e-01 7.35e-02 6.89e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 5.81e-01 7.32e-02 7.18e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 4.68e-01 -7.30e-02 6.26e-01
CELL CYCLE MITOTIC 470 7.02e-03 7.28e-02 3.28e-02
GAB1 SIGNALOSOME 14 6.38e-01 7.27e-02 7.58e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 6.26e-01 7.27e-02 7.51e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 5.47e-01 -7.26e-02 6.91e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 5.00e-01 7.25e-02 6.52e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 6.27e-01 7.24e-02 7.51e-01
CA2 PATHWAY 56 3.53e-01 7.18e-02 5.28e-01
INOSITOL PHOSPHATE METABOLISM 47 3.95e-01 7.17e-02 5.63e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 35 4.64e-01 7.15e-02 6.22e-01
VIRAL MESSENGER RNA SYNTHESIS 42 4.26e-01 -7.10e-02 5.89e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 3.34e-01 -7.09e-02 5.12e-01
CELL JUNCTION ORGANIZATION 75 2.93e-01 7.03e-02 4.71e-01
DNA REPAIR 291 4.12e-02 -6.97e-02 1.25e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 5.64e-01 6.94e-02 7.05e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 5.74e-01 -6.93e-02 7.13e-01
REGULATION OF TNFR1 SIGNALING 34 4.85e-01 6.92e-02 6.40e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 5.75e-01 6.91e-02 7.13e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 5.43e-01 6.89e-02 6.89e-01
ION TRANSPORT BY P TYPE ATPASES 47 4.18e-01 -6.83e-02 5.84e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 5.12e-01 6.81e-02 6.64e-01
SIGNALING BY NTRK2 TRKB 24 5.65e-01 6.79e-02 7.05e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 3.07e-01 6.78e-02 4.83e-01
NEUREXINS AND NEUROLIGINS 54 3.94e-01 -6.71e-02 5.62e-01
TRANSCRIPTION OF THE HIV GENOME 67 3.43e-01 6.70e-02 5.20e-01
ENDOGENOUS STEROLS 21 5.95e-01 6.70e-02 7.27e-01
CELLULAR SENESCENCE 141 1.71e-01 -6.69e-02 3.43e-01
CDC42 GTPASE CYCLE 153 1.54e-01 -6.69e-02 3.18e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 6.07e-01 -6.64e-02 7.38e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 7.17e-01 -6.62e-02 8.27e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 2.38e-01 6.61e-02 4.17e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 6.80e-01 -6.61e-02 7.97e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 6.50e-01 6.56e-02 7.70e-01
RNA POLYMERASE III CHAIN ELONGATION 18 6.32e-01 -6.53e-02 7.54e-01
RAC3 GTPASE CYCLE 88 2.93e-01 6.49e-02 4.71e-01
REGULATION OF PTEN GENE TRANSCRIPTION 59 3.90e-01 -6.47e-02 5.59e-01
DEVELOPMENTAL BIOLOGY 809 1.87e-03 6.47e-02 1.20e-02
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 5.92e-01 -6.46e-02 7.25e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 4.10e-01 -6.43e-02 5.77e-01
SIGNALLING TO RAS 20 6.20e-01 -6.40e-02 7.46e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 6.22e-01 -6.37e-02 7.47e-01
SIGNALING BY NOTCH2 33 5.27e-01 -6.36e-02 6.78e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 4.51e-01 6.35e-02 6.13e-01
REGULATION OF KIT SIGNALING 16 6.61e-01 -6.33e-02 7.80e-01
NUCLEAR ENVELOPE BREAKDOWN 47 4.56e-01 -6.28e-02 6.16e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 4.62e-01 -6.27e-02 6.20e-01
NUCLEAR SIGNALING BY ERBB4 31 5.48e-01 6.24e-02 6.91e-01
METABOLISM OF STEROID HORMONES 20 6.29e-01 6.24e-02 7.52e-01
SEMAPHORIN INTERACTIONS 64 3.90e-01 -6.22e-02 5.59e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 281 7.43e-02 -6.20e-02 1.94e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 4.13e-01 -6.17e-02 5.78e-01
TRNA PROCESSING IN THE NUCLEUS 56 4.27e-01 -6.14e-02 5.89e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 100 2.89e-01 6.14e-02 4.68e-01
MHC CLASS II ANTIGEN PRESENTATION 103 2.83e-01 6.13e-02 4.60e-01
CELL CELL COMMUNICATION 107 2.75e-01 6.12e-02 4.53e-01
SIGNALING BY PDGF 55 4.34e-01 -6.10e-02 5.97e-01
RET SIGNALING 37 5.22e-01 6.09e-02 6.72e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 5.92e-01 -6.08e-02 7.25e-01
MAP2K AND MAPK ACTIVATION 36 5.29e-01 6.07e-02 6.78e-01
CA DEPENDENT EVENTS 36 5.30e-01 6.05e-02 6.78e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 6.75e-01 6.05e-02 7.93e-01
MITOCHONDRIAL BIOGENESIS 92 3.19e-01 6.01e-02 4.96e-01
ONCOGENE INDUCED SENESCENCE 32 5.56e-01 -6.01e-02 6.98e-01
CELLULAR RESPONSE TO HEAT STRESS 95 3.13e-01 5.99e-02 4.88e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 4.95e-01 -5.88e-02 6.49e-01
NICOTINAMIDE SALVAGING 15 6.95e-01 -5.86e-02 8.10e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 141 2.31e-01 5.84e-02 4.11e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.14e-01 5.84e-02 7.42e-01
ION CHANNEL TRANSPORT 138 2.39e-01 -5.81e-02 4.17e-01
RHOF GTPASE CYCLE 40 5.29e-01 5.76e-02 6.78e-01
CIRCADIAN CLOCK 68 4.16e-01 5.70e-02 5.82e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 4.34e-01 5.70e-02 5.97e-01
FGFR2 ALTERNATIVE SPLICING 26 6.15e-01 -5.70e-02 7.43e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.51e-01 -5.67e-02 6.94e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 4.01e-01 -5.64e-02 5.69e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 3.56e-01 5.63e-02 5.29e-01
SIGNALING BY NOTCH 188 1.86e-01 5.60e-02 3.64e-01
THE PHOTOTRANSDUCTION CASCADE 20 6.65e-01 5.60e-02 7.84e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 1.72e-02 5.60e-02 6.83e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT 183 1.92e-01 5.59e-02 3.68e-01
DNA DOUBLE STRAND BREAK REPAIR 136 2.61e-01 -5.59e-02 4.39e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 7.49e-01 -5.57e-02 8.53e-01
REPRODUCTION 75 4.06e-01 -5.55e-02 5.74e-01
DISEASES OF PROGRAMMED CELL DEATH 54 4.81e-01 5.55e-02 6.37e-01
REGULATION OF BETA CELL DEVELOPMENT 24 6.43e-01 -5.46e-02 7.64e-01
MITOTIC PROPHASE 92 3.69e-01 5.43e-02 5.40e-01
DISEASES OF METABOLISM 198 1.89e-01 5.42e-02 3.66e-01
RNA POLYMERASE I TRANSCRIPTION 67 4.44e-01 5.41e-02 6.08e-01
SIGNALING BY NOTCH1 75 4.19e-01 -5.40e-02 5.84e-01
G ALPHA S SIGNALLING EVENTS 103 3.46e-01 5.37e-02 5.23e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 3.47e-01 -5.36e-02 5.23e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 6.82e-01 5.30e-02 7.98e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 6.28e-01 -5.30e-02 7.51e-01
NOD1 2 SIGNALING PATHWAY 35 5.88e-01 5.29e-02 7.22e-01
INTERFERON ALPHA BETA SIGNALING 52 5.18e-01 5.18e-02 6.69e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 61 4.85e-01 5.17e-02 6.40e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 7.78e-01 5.14e-02 8.70e-01
UNWINDING OF DNA 12 7.58e-01 5.14e-02 8.59e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 7.79e-01 5.12e-02 8.70e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 7.32e-01 -5.10e-02 8.40e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 7.71e-01 -5.06e-02 8.67e-01
PI3K AKT SIGNALING IN CANCER 88 4.12e-01 5.06e-02 5.78e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 6.98e-01 5.01e-02 8.12e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 5.53e-01 5.00e-02 6.96e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 7.74e-01 5.00e-02 8.68e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 235 1.88e-01 5.00e-02 3.65e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 7.56e-01 4.98e-02 8.58e-01
MITOTIC G2 G2 M PHASES 184 2.47e-01 4.96e-02 4.23e-01
CHROMOSOME MAINTENANCE 103 3.86e-01 4.94e-02 5.56e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 5.89e-01 4.87e-02 7.23e-01
TRNA AMINOACYLATION 42 5.85e-01 4.87e-02 7.21e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.71e-01 4.86e-02 8.67e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 6.20e-01 -4.85e-02 7.46e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 6.11e-01 -4.84e-02 7.40e-01
SIGNALING BY NOTCH3 48 5.68e-01 -4.77e-02 7.08e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 7.85e-01 4.74e-02 8.73e-01
CELL CYCLE 588 5.06e-02 4.74e-02 1.44e-01
SENSORY PERCEPTION 140 3.34e-01 4.73e-02 5.12e-01
NICOTINATE METABOLISM 24 6.93e-01 -4.66e-02 8.09e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 6.25e-01 -4.64e-02 7.50e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 27 6.77e-01 -4.64e-02 7.94e-01
HOMOLOGY DIRECTED REPAIR 107 4.17e-01 -4.55e-02 5.82e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 4.74e-01 -4.55e-02 6.31e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 4.65e-01 -4.54e-02 6.23e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 6.52e-01 4.54e-02 7.71e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 5.06e-01 -4.47e-02 6.58e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 4.59e-01 -4.40e-02 6.18e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 184 3.06e-01 4.38e-02 4.83e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 7.30e-01 -4.36e-02 8.38e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 117 4.22e-01 -4.30e-02 5.86e-01
METABOLISM OF FOLATE AND PTERINES 15 7.74e-01 4.29e-02 8.68e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 8.16e-01 -4.25e-02 8.93e-01
CARDIAC CONDUCTION 108 4.47e-01 -4.24e-02 6.09e-01
PLASMA LIPOPROTEIN REMODELING 15 7.77e-01 -4.23e-02 8.70e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 5.57e-01 4.22e-02 6.98e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.37e-01 -4.21e-02 7.58e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 8.10e-01 4.19e-02 8.91e-01
PHOSPHORYLATION OF THE APC C 17 7.68e-01 4.13e-02 8.65e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 6.97e-01 4.11e-02 8.12e-01
AGGREPHAGY 35 6.75e-01 4.10e-02 7.93e-01
CD28 DEPENDENT PI3K AKT SIGNALING 19 7.59e-01 -4.07e-02 8.59e-01
ATTENUATION PHASE 24 7.31e-01 4.05e-02 8.39e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 5.53e-01 -4.02e-02 6.96e-01
PYRIMIDINE CATABOLISM 10 8.26e-01 -4.02e-02 9.01e-01
SLC TRANSPORTER DISORDERS 69 5.65e-01 4.01e-02 7.05e-01
SIGNALING BY ACTIVIN 12 8.10e-01 4.01e-02 8.91e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 6.33e-01 -3.98e-02 7.55e-01
LAMININ INTERACTIONS 27 7.20e-01 -3.98e-02 8.30e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 7.27e-01 -3.96e-02 8.35e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 7.67e-01 -3.93e-02 8.65e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 5.47e-01 -3.92e-02 6.91e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 7.07e-01 -3.90e-02 8.19e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.08e-01 -3.90e-02 8.91e-01
DISEASES OF GLYCOSYLATION 124 4.54e-01 -3.89e-02 6.15e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 7.94e-01 -3.89e-02 8.81e-01
PHOSPHOLIPID METABOLISM 185 3.63e-01 3.88e-02 5.35e-01
NEPHRIN FAMILY INTERACTIONS 22 7.55e-01 3.85e-02 8.58e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 7.85e-01 3.83e-02 8.73e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 6.98e-01 3.79e-02 8.12e-01
RHOC GTPASE CYCLE 73 5.84e-01 -3.71e-02 7.19e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 7.09e-01 -3.70e-02 8.20e-01
GLYCOLYSIS 66 6.05e-01 3.68e-02 7.37e-01
MEIOSIS 63 6.14e-01 -3.68e-02 7.42e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 7.25e-01 3.65e-02 8.34e-01
RHOB GTPASE CYCLE 67 6.06e-01 -3.64e-02 7.38e-01
MEIOTIC SYNAPSIS 39 6.94e-01 -3.64e-02 8.10e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 6.68e-01 -3.62e-02 7.85e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 7.67e-01 3.58e-02 8.65e-01
MRNA CAPPING 29 7.42e-01 3.54e-02 8.48e-01
RHO GTPASE CYCLE 427 2.17e-01 3.49e-02 3.94e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 6.10e-01 3.46e-02 7.40e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 6.89e-01 -3.45e-02 8.06e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 175 4.33e-01 3.44e-02 5.97e-01
REGULATION OF TP53 ACTIVITY 148 4.78e-01 -3.39e-02 6.35e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 6.52e-01 -3.34e-02 7.71e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 82 6.03e-01 -3.33e-02 7.36e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 15 8.27e-01 3.26e-02 9.01e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 7.51e-01 3.24e-02 8.54e-01
INTERLEUKIN 17 SIGNALING 66 6.55e-01 3.18e-02 7.73e-01
EXTRACELLULAR MATRIX ORGANIZATION 239 4.12e-01 -3.08e-02 5.78e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 7.03e-01 3.05e-02 8.17e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 51 7.09e-01 3.02e-02 8.20e-01
ACYL CHAIN REMODELLING OF PC 17 8.33e-01 2.96e-02 9.04e-01
GOLGI TO ER RETROGRADE TRANSPORT 118 5.87e-01 2.90e-02 7.22e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 8.58e-01 -2.87e-02 9.23e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 176 5.13e-01 2.86e-02 6.65e-01
NUCLEOTIDE SALVAGE 21 8.22e-01 -2.84e-02 8.98e-01
NONHOMOLOGOUS END JOINING NHEJ 43 7.48e-01 -2.83e-02 8.53e-01
RHOU GTPASE CYCLE 33 7.82e-01 -2.79e-02 8.72e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 8.35e-01 2.76e-02 9.04e-01
METABOLISM OF FAT SOLUBLE VITAMINS 31 7.91e-01 2.75e-02 8.79e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 7.13e-01 2.70e-02 8.23e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 8.35e-01 -2.70e-02 9.04e-01
RAC1 GTPASE CYCLE 177 5.38e-01 2.68e-02 6.87e-01
DNA METHYLATION 20 8.36e-01 -2.68e-02 9.04e-01
OTHER INTERLEUKIN SIGNALING 20 8.41e-01 2.60e-02 9.07e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 8.00e-01 -2.58e-02 8.85e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 8.63e-01 -2.49e-02 9.28e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 8.69e-01 -2.46e-02 9.28e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 8.35e-01 2.45e-02 9.04e-01
ONCOGENIC MAPK SIGNALING 77 7.11e-01 2.45e-02 8.21e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 8.32e-01 -2.41e-02 9.04e-01
INTEGRIN CELL SURFACE INTERACTIONS 68 7.35e-01 -2.37e-02 8.42e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 8.69e-01 2.37e-02 9.28e-01
CELL CELL JUNCTION ORGANIZATION 50 7.72e-01 2.37e-02 8.67e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 8.79e-01 2.35e-02 9.34e-01
INTERLEUKIN 6 SIGNALING 10 8.98e-01 -2.35e-02 9.41e-01
VISUAL PHOTOTRANSDUCTION 58 7.57e-01 2.35e-02 8.58e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 8.14e-01 -2.33e-02 8.93e-01
ACYL CHAIN REMODELLING OF PS 14 8.80e-01 -2.32e-02 9.34e-01
ERBB2 REGULATES CELL MOTILITY 14 8.81e-01 2.31e-02 9.34e-01
POTASSIUM CHANNELS 90 7.06e-01 -2.30e-02 8.19e-01
G1 S SPECIFIC TRANSCRIPTION 26 8.40e-01 2.29e-02 9.07e-01
EXTENSION OF TELOMERES 50 7.83e-01 -2.25e-02 8.72e-01
PREGNENOLONE BIOSYNTHESIS 12 8.94e-01 2.23e-02 9.39e-01
HSF1 DEPENDENT TRANSACTIVATION 34 8.22e-01 2.23e-02 8.98e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 8.03e-01 2.20e-02 8.87e-01
O LINKED GLYCOSYLATION OF MUCINS 40 8.11e-01 2.19e-02 8.91e-01
BASE EXCISION REPAIR 56 7.77e-01 -2.18e-02 8.70e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 8.69e-01 -2.13e-02 9.28e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 8.95e-01 2.12e-02 9.39e-01
MITOTIC PROMETAPHASE 175 6.36e-01 -2.08e-02 7.58e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 7.98e-01 -2.06e-02 8.83e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 9.12e-01 2.03e-02 9.49e-01
RESOLUTION OF ABASIC SITES AP SITES 37 8.32e-01 -2.02e-02 9.04e-01
SENSORY PROCESSING OF SOUND 61 7.85e-01 2.02e-02 8.73e-01
RHOD GTPASE CYCLE 50 8.09e-01 1.98e-02 8.91e-01
MEIOTIC RECOMBINATION 38 8.33e-01 1.97e-02 9.04e-01
TELOMERE MAINTENANCE 79 7.62e-01 1.97e-02 8.61e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 8.71e-01 -1.95e-02 9.29e-01
HCMV INFECTION 102 7.36e-01 -1.94e-02 8.42e-01
P38MAPK EVENTS 13 9.08e-01 -1.86e-02 9.47e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 55 8.12e-01 1.86e-02 8.91e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 8.68e-01 1.79e-02 9.28e-01
INTERLEUKIN 15 SIGNALING 12 9.17e-01 -1.74e-02 9.52e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 7.97e-01 1.72e-02 8.83e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 8.80e-01 1.71e-02 9.34e-01
RMTS METHYLATE HISTONE ARGININES 42 8.49e-01 -1.70e-02 9.14e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 9.14e-01 1.62e-02 9.50e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 8.87e-01 -1.61e-02 9.37e-01
G0 AND EARLY G1 24 8.92e-01 1.60e-02 9.39e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 49 8.47e-01 1.60e-02 9.13e-01
RHOA GTPASE CYCLE 143 7.43e-01 1.59e-02 8.49e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 8.70e-01 -1.58e-02 9.28e-01
SNRNP ASSEMBLY 51 8.47e-01 -1.56e-02 9.13e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 9.02e-01 1.55e-02 9.43e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 9.24e-01 -1.53e-02 9.57e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 85 8.08e-01 -1.52e-02 8.91e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 8.85e-01 1.52e-02 9.37e-01
SUMOYLATION 162 7.44e-01 -1.49e-02 8.49e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.35e-01 1.48e-02 9.60e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 9.10e-01 -1.46e-02 9.48e-01
INTRA GOLGI TRAFFIC 43 8.70e-01 1.44e-02 9.28e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 12 9.31e-01 1.43e-02 9.60e-01
MUSCLE CONTRACTION 162 7.62e-01 -1.38e-02 8.61e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 9.35e-01 -1.36e-02 9.60e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 8.95e-01 1.33e-02 9.39e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 8.65e-01 -1.27e-02 9.28e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 8.95e-01 1.26e-02 9.39e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 8.90e-01 -1.24e-02 9.38e-01
HCMV LATE EVENTS 64 8.67e-01 1.21e-02 9.28e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 12 9.42e-01 1.21e-02 9.63e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 9.30e-01 -1.19e-02 9.60e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 9.39e-01 1.19e-02 9.61e-01
DEATH RECEPTOR SIGNALLING 134 8.17e-01 -1.16e-02 8.94e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 35 9.06e-01 1.15e-02 9.47e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 8.87e-01 -1.09e-02 9.37e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 9.42e-01 -1.08e-02 9.63e-01
INTERLEUKIN 6 FAMILY SIGNALING 18 9.37e-01 -1.07e-02 9.60e-01
HIV ELONGATION ARREST AND RECOVERY 32 9.17e-01 1.07e-02 9.52e-01
G2 M DNA DAMAGE CHECKPOINT 65 8.82e-01 1.06e-02 9.34e-01
SIGNALING BY SCF KIT 41 9.08e-01 1.05e-02 9.47e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 8.80e-01 1.04e-02 9.34e-01
PRC2 METHYLATES HISTONES AND DNA 29 9.30e-01 -9.47e-03 9.60e-01
DAG AND IP3 SIGNALING 40 9.18e-01 -9.44e-03 9.52e-01
HYALURONAN METABOLISM 15 9.52e-01 9.04e-03 9.70e-01
ACTIVATION OF BH3 ONLY PROTEINS 28 9.34e-01 -8.98e-03 9.60e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 9.01e-01 8.90e-03 9.43e-01
PD 1 SIGNALING 10 9.62e-01 -8.70e-03 9.76e-01
INTERFERON GAMMA SIGNALING 73 9.01e-01 8.47e-03 9.43e-01
ADHERENS JUNCTIONS INTERACTIONS 30 9.36e-01 -8.42e-03 9.60e-01
DNA DAMAGE BYPASS 46 9.23e-01 8.20e-03 9.57e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 9.36e-01 7.99e-03 9.60e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 9.66e-01 -7.85e-03 9.79e-01
FLT3 SIGNALING 36 9.36e-01 7.71e-03 9.60e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 9.60e-01 -7.50e-03 9.76e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 9.58e-01 -6.30e-03 9.75e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 9.70e-01 5.49e-03 9.82e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 9.34e-01 5.49e-03 9.60e-01
DEADENYLATION OF MRNA 25 9.62e-01 -5.47e-03 9.76e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 9.46e-01 -5.28e-03 9.65e-01
ION HOMEOSTASIS 48 9.53e-01 4.94e-03 9.70e-01
NEURONAL SYSTEM 363 8.75e-01 -4.80e-03 9.32e-01
L1CAM INTERACTIONS 109 9.32e-01 4.77e-03 9.60e-01
TRANSCRIPTIONAL REGULATION BY TP53 338 8.90e-01 4.39e-03 9.38e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 9.77e-01 4.37e-03 9.85e-01
RNA POLYMERASE II TRANSCRIPTION 1083 8.15e-01 4.25e-03 8.93e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 9.75e-01 -4.09e-03 9.85e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 9.83e-01 3.20e-03 9.88e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 9.76e-01 3.13e-03 9.85e-01
INTERFERON SIGNALING 160 9.47e-01 -3.06e-03 9.66e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 9.79e-01 2.86e-03 9.86e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 9.83e-01 -2.64e-03 9.88e-01
MET PROMOTES CELL MOTILITY 39 9.78e-01 2.61e-03 9.85e-01
VXPX CARGO TARGETING TO CILIUM 19 9.86e-01 -2.36e-03 9.89e-01
HIV TRANSCRIPTION ELONGATION 42 9.80e-01 2.23e-03 9.86e-01
PI METABOLISM 79 9.77e-01 1.85e-03 9.85e-01
ESTROGEN DEPENDENT GENE EXPRESSION 100 9.76e-01 -1.74e-03 9.85e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 9.92e-01 1.55e-03 9.93e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 20 9.92e-01 1.36e-03 9.93e-01
MISMATCH REPAIR 14 9.95e-01 -1.05e-03 9.95e-01
FLT3 SIGNALING IN DISEASE 27 1.00e+00 1.34e-05 1.00e+00


Detailed Gene set reports



TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
1096
set TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize 11
pANOVA 0.000176
s.dist 0.653
p.adjustANOVA 0.00166



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ctss 7951
Lgmn 7925
Ctsb 7844
Tlr7 7102
Hsp90b1 6318
Unc93b1 5764
Ctsl 5477
Tlr3 4653
Ctsk 4393
Cnpy3 1652
Tlr9 -1435

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ctss 7951
Lgmn 7925
Ctsb 7844
Tlr7 7102
Hsp90b1 6318
Unc93b1 5764
Ctsl 5477
Tlr3 4653
Ctsk 4393
Cnpy3 1652
Tlr9 -1435


NUCLEOTIDE LIKE PURINERGIC RECEPTORS

NUCLEOTIDE LIKE PURINERGIC RECEPTORS
656
set NUCLEOTIDE LIKE PURINERGIC RECEPTORS
setSize 13
pANOVA 0.000535
s.dist 0.555
p.adjustANOVA 0.00439



Top enriched genes

Top 20 genes
GeneID Gene Rank
P2ry12 7413
P2ry1 7377
Adora3 7105
P2ry14 7091
P2ry13 5908
Gpr17 5849
Adora2b 5032
Adora2a 4708
P2ry6 3719
Lpar4 2292
Adora1 931
Lpar6 569
P2ry2 -495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
P2ry12 7413
P2ry1 7377
Adora3 7105
P2ry14 7091
P2ry13 5908
Gpr17 5849
Adora2b 5032
Adora2a 4708
P2ry6 3719
Lpar4 2292
Adora1 931
Lpar6 569
P2ry2 -495


ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
39
set ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize 19
pANOVA 4.07e-05
s.dist 0.544
p.adjustANOVA 0.00051



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng12 7806
P2ry12 7413
Gng10 7124
Gng5 7046
Gnai3 7033
Gnb5 6692
Gng11 6628
Gng7 5129
Gnai1 5064
Gng3 4233
Gnai2 4102
Gngt2 2842
Gnb4 2642
Gng8 2077
Gng4 2019
Gng2 1559
Gnb2 1365
Gng13 921
Gnb1 594

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng12 7806
P2ry12 7413
Gng10 7124
Gng5 7046
Gnai3 7033
Gnb5 6692
Gng11 6628
Gng7 5129
Gnai1 5064
Gng3 4233
Gnai2 4102
Gngt2 2842
Gnb4 2642
Gng8 2077
Gng4 2019
Gng2 1559
Gnb2 1365
Gng13 921
Gnb1 594


ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
72
set ASPARTATE AND ASPARAGINE METABOLISM
setSize 10
pANOVA 0.00302
s.dist 0.542
p.adjustANOVA 0.0172



Top enriched genes

Top 20 genes
GeneID Gene Rank
Asns 7504
Slc25a13 7183
Folh1 6671
Got1 6570
Got2 5979
Naalad2 5317
Aspa 4957
Slc25a12 4529
Nat8l 103
Aspg -5663

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Asns 7504
Slc25a13 7183
Folh1 6671
Got1 6570
Got2 5979
Naalad2 5317
Aspa 4957
Slc25a12 4529
Nat8l 103
Aspg -5663


COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
170
set COMPLEX I BIOGENESIS
setSize 56
pANOVA 4.2e-12
s.dist 0.535
p.adjustANOVA 2.88e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ndufb5 7944
Ndufv2 7897
Ndufc1 7879
Ndufaf4 7875
mt-Nd4 7791
mt-Nd3 7696
mt-Nd6 7692
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
Ndufa10 7480
mt-Nd2 7440
Timmdc1 7361
Ndufaf1 7140
Ndufa5 7111
Ndufb9 6752
Ndufaf6 6597
Ndufb4 6558

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufb5 7944
Ndufv2 7897
Ndufc1 7879
Ndufaf4 7875
mt-Nd4 7791
mt-Nd3 7696
mt-Nd6 7692
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
Ndufa10 7480
mt-Nd2 7440
Timmdc1 7361
Ndufaf1 7140
Ndufa5 7111
Ndufb9 6752
Ndufaf6 6597
Ndufb4 6558
Ndufb11 6478
Ndufs1 6380
Ndufaf2 6187
Ndufb8 6186
Ndufs3 6000
Ndufa13 5845
Ndufaf5 5684
Ndufab1 5620
Ndufc2 4815
Ndufa6 4771
Ndufs5 4712
Ndufa7 4534
Ndufb6 4184
Ndufs6 3839
Ndufv1 3473
Ndufb1 3424
Tmem126b 3234
Ndufa1 2822
Ndufb3 2499
Ecsit 2347
Ndufs7 2105
Acad9 1990
Ndufa8 1700
Ndufb7 1370
Ndufb2 1235
Ndufs8 350
Ndufb10 315
Ndufv3 202
Nubpl 24
Ndufa3 -187
Ndufa11 -921
Ndufaf3 -1144
Ndufa9 -1155
Ndufaf7 -1201
Ndufa2 -1362
Tmem186 -7244


SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
1045
set SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize 20
pANOVA 3.51e-05
s.dist 0.534
p.adjustANOVA 0.000455



Top enriched genes

Top 20 genes
GeneID Gene Rank
Elovl1 8118
Hsd17b12 7866
Elovl5 7774
Hacd3 7769
Acsbg1 7556
Acsl3 7541
Hacd1 7417
Hacd2 7201
Elovl4 6855
Acsl4 5771
Elovl2 5586
Tecr 4330
Acsl1 4281
Elovl7 3641
Acsl6 3624
Elovl6 1439
Hacd4 -253
Acsl5 -955
Slc27a3 -5087
Acsf3 -5411

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elovl1 8118
Hsd17b12 7866
Elovl5 7774
Hacd3 7769
Acsbg1 7556
Acsl3 7541
Hacd1 7417
Hacd2 7201
Elovl4 6855
Acsl4 5771
Elovl2 5586
Tecr 4330
Acsl1 4281
Elovl7 3641
Acsl6 3624
Elovl6 1439
Hacd4 -253
Acsl5 -955
Slc27a3 -5087
Acsf3 -5411


TRIGLYCERIDE CATABOLISM

TRIGLYCERIDE CATABOLISM
1137
set TRIGLYCERIDE CATABOLISM
setSize 14
pANOVA 0.000668
s.dist 0.525
p.adjustANOVA 0.00532



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cav1 8035
Plin3 7871
Ppp1cc 7074
Abhd5 7016
Ppp1cb 6637
Prkacb 6521
Fabp5 6248
Lipe 4718
Ppp1ca 4208
Gpd2 3444
Fabp3 1587
Mgll 871
Prkaca 1
Fabp7 -5738

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cav1 8035
Plin3 7871
Ppp1cc 7074
Abhd5 7016
Ppp1cb 6637
Prkacb 6521
Fabp5 6248
Lipe 4718
Ppp1ca 4208
Gpd2 3444
Fabp3 1587
Mgll 871
Prkaca 1
Fabp7 -5738


PINK1 PRKN MEDIATED MITOPHAGY

PINK1 PRKN MEDIATED MITOPHAGY
704
set PINK1 PRKN MEDIATED MITOPHAGY
setSize 22
pANOVA 2.44e-05
s.dist 0.52
p.adjustANOVA 0.000335



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tomm20 7698
Tomm6 6887
Atg5 6462
Rps27a 6287
Map1lc3b 5969
Vdac1 5870
Tomm22 5805
Pink1 5610
Tomm70a 5588
Sqstm1 5432
Atg12 4934
Uba52 4679
Ubb 4462
Map1lc3a 4291
Mterf3 4096
Prkn 4076
Tomm7 2400
Tomm5 1993
Tomm40 1049
Mfn2 -565

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tomm20 7698
Tomm6 6887
Atg5 6462
Rps27a 6287
Map1lc3b 5969
Vdac1 5870
Tomm22 5805
Pink1 5610
Tomm70a 5588
Sqstm1 5432
Atg12 4934
Uba52 4679
Ubb 4462
Map1lc3a 4291
Mterf3 4096
Prkn 4076
Tomm7 2400
Tomm5 1993
Tomm40 1049
Mfn2 -565
Ubc -674
Mfn1 -1475


FRS MEDIATED FGFR4 SIGNALING

FRS MEDIATED FGFR4 SIGNALING
344
set FRS MEDIATED FGFR4 SIGNALING
setSize 12
pANOVA 0.00192
s.dist 0.517
p.adjustANOVA 0.0122



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Frs2 4435
Fgf9 4376
Nras 3869
Fgf18 3657
Ptpn11 3576
Frs3 2469
Grb2 1153
Sos1 677

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Frs2 4435
Fgf9 4376
Nras 3869
Fgf18 3657
Ptpn11 3576
Frs3 2469
Grb2 1153
Sos1 677


SHC MEDIATED CASCADE FGFR4

SHC MEDIATED CASCADE FGFR4
921
set SHC MEDIATED CASCADE FGFR4
setSize 10
pANOVA 0.00474
s.dist 0.516
p.adjustANOVA 0.0244



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Fgf9 4376
Nras 3869
Fgf18 3657
Shc1 2132
Grb2 1153
Sos1 677

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Fgf9 4376
Nras 3869
Fgf18 3657
Shc1 2132
Grb2 1153
Sos1 677


EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
302
set EUKARYOTIC TRANSLATION ELONGATION
setSize 87
pANOVA 1.06e-16
s.dist 0.514
p.adjustANOVA 1.12e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rpl23a 7569
Rpl24 7540
Rps27l 7476
Eef1g 7474
Rps8 7351
Rps3a1 7090
Eef1a1 7063
Rpl22l1 6945
Rps23 6815
Eef1a2 6782
Rpl6 6753
Rps4x 6720
Rpl23 6522
Rps24 6391
Rps7 6301
Rps27a 6287
Rpl37a 6189
Rpl4 6147

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rpl23a 7569
Rpl24 7540
Rps27l 7476
Eef1g 7474
Rps8 7351
Rps3a1 7090
Eef1a1 7063
Rpl22l1 6945
Rps23 6815
Eef1a2 6782
Rpl6 6753
Rps4x 6720
Rpl23 6522
Rps24 6391
Rps7 6301
Rps27a 6287
Rpl37a 6189
Rpl4 6147
Rpl13a 6123
Rpl5 6038
Rpl3 5935
Rplp0 5890
Rpl22 5876
Rps29 5797
Fau 5746
Rpl31 5692
Rpl17 5602
Rpl14 5533
Rps18 5494
Rpl35a 5482
Eef1b2 5431
Rps20 5420
Rpl18a 5350
Rps19 5329
Rpl11 5300
Eef2 5248
Rps26 5233
Rpl27 5209
Rpl30 5196
Rpl9 5140
Rpl7 5019
Rps5 4949
Rpl39 4872
Uba52 4679
Rpl32 4626
Rpl35 4264
Rpl36a 4037
Rpl38 3999
Rps28 3895
Rpl29 3662
Rpl26 3633
Rpl19 3567
Rps11 3518
Rpl34 3514
Eef1d 3439
Rpl13 3236
Rps21 3188
Rpsa 3113
Rpl15 3020
Rpl37 2953
Rpl27a 2791
Rps17 2734
Rpl21 2678
Rpl8 2675
Rpl7a 2288
Rps27 2204
Rps13 2150
Rps6 2046
Rps16 1905
Rpl36al 1812
Rps2 1413
Rps3 1378
Rps10 1099
Rpl28 833
Rplp2 775
Rpl10a 728
Rps15 684
Rpl18 262
Rps15a -368
Rpl36 -379
Rps12 -530
Rplp1 -556
Rps14 -1429
Rpl10 -3715
Rpl12 -7475


CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING
188
set CRMPS IN SEMA3A SIGNALING
setSize 16
pANOVA 0.000387
s.dist -0.512
p.adjustANOVA 0.00332



Top enriched genes

Top 20 genes
GeneID Gene Rank
Plxna4 -7942
Plxna3 -7852
Plxna1 -7441
Dpysl2 -7160
Crmp1 -6316
Dpysl4 -6204
Dpysl3 -5932
Dpysl5 -5623
Plxna2 -4399
Cdk5 -4320
Nrp1 -3883
Cdk5r1 -2371
Gsk3b -1843
Fes -725
Fyn 236
Sema3a 873

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plxna4 -7942
Plxna3 -7852
Plxna1 -7441
Dpysl2 -7160
Crmp1 -6316
Dpysl4 -6204
Dpysl3 -5932
Dpysl5 -5623
Plxna2 -4399
Cdk5 -4320
Nrp1 -3883
Cdk5r1 -2371
Gsk3b -1843
Fes -725
Fyn 236
Sema3a 873


RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
831
set RESPIRATORY ELECTRON TRANSPORT
setSize 102
pANOVA 4.5e-19
s.dist 0.511
p.adjustANOVA 8.75e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
Coq10b 8017
Ndufb5 7944
Ndufv2 7897
Ndufc1 7879
mt-Co1 7877
Ndufaf4 7875
mt-Nd4 7791
Cox7a2l 7766
Sdhc 7740
mt-Nd3 7696
mt-Nd6 7692
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
mt-Co2 7495
Ndufa10 7480
mt-Nd2 7440
mt-Cytb 7410

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Coq10b 8017
Ndufb5 7944
Ndufv2 7897
Ndufc1 7879
mt-Co1 7877
Ndufaf4 7875
mt-Nd4 7791
Cox7a2l 7766
Sdhc 7740
mt-Nd3 7696
mt-Nd6 7692
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
mt-Co2 7495
Ndufa10 7480
mt-Nd2 7440
mt-Cytb 7410
Timmdc1 7361
Cycs 7344
Uqcrb 7297
mt-Co3 7283
Ndufaf1 7140
Ndufa5 7111
Cox5a 7096
Surf1 7002
Ndufa4 6926
Ndufb9 6752
Ndufaf6 6597
Ndufb4 6558
Cox6a1 6525
Ndufb11 6478
Ndufs1 6380
Ndufaf2 6187
Ndufb8 6186
Sco2 6002
Ndufs3 6000
Ndufa13 5845
Cox7c 5828
Ndufaf5 5684
Ndufab1 5620
Uqcrc2 5490
Coq10a 5363
Cox20 5321
Cox5b 5286
Sdha 5219
Sdhd 5008
Taco1 4975
Cox6c 4919
Ndufc2 4815
Ndufa6 4771
Cox16 4725
Ndufs5 4712
Cox8a 4557
Ndufa7 4534
Cox7b 4523
Sdhb 4460
Uqcrq 4400
Cox18 4186
Ndufb6 4184
Uqcrfs1 3896
Ndufs6 3839
Ndufv1 3473
Ndufb1 3424
Uqcrh 3303
Tmem126b 3234
Etfa 3125
Ndufa1 2822
Ndufb3 2499
Ecsit 2347
Cyc1 2327
Ndufs7 2105
Etfb 2001
Acad9 1990
Cox6b1 1748
Ndufa8 1700
Ndufb7 1370
Ndufb2 1235
Etfdh 1105
Uqcr10 944
Uqcrc1 825
Cox4i1 421
Ndufs8 350
Ndufb10 315
Ndufv3 202
Sco1 89
Nubpl 24
Ndufa3 -187
Trap1 -275
Uqcr11 -884
Ndufa11 -921
Ndufaf3 -1144
Ndufa9 -1155
Ndufaf7 -1201
Ndufa2 -1362
Cox14 -2274
Cox19 -4424
Lrpprc -6913
Cox11 -7075
Tmem186 -7244


CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
153
set CITRIC ACID CYCLE TCA CYCLE
setSize 22
pANOVA 3.54e-05
s.dist 0.509
p.adjustANOVA 0.000455



Top enriched genes

Top 20 genes
GeneID Gene Rank
Idh3a 7890
Sdhc 7740
Suclg2 7068
Sucla2 6894
Nnt 6565
Idh2 6267
Suclg1 5310
Sdha 5219
Fh1 5176
Sdhd 5008
Cs 4980
Dld 4601
Sdhb 4460
Aco2 4210
Ogdh 3795
Mdh2 3695
Me2 3460
Fahd1 1568
Me3 55
Dlst -353

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Idh3a 7890
Sdhc 7740
Suclg2 7068
Sucla2 6894
Nnt 6565
Idh2 6267
Suclg1 5310
Sdha 5219
Fh1 5176
Sdhd 5008
Cs 4980
Dld 4601
Sdhb 4460
Aco2 4210
Ogdh 3795
Mdh2 3695
Me2 3460
Fahd1 1568
Me3 55
Dlst -353
Idh3g -2178
Idh3b -2457


PI 3K CASCADE FGFR4

PI 3K CASCADE FGFR4
700
set PI 3K CASCADE FGFR4
setSize 10
pANOVA 0.00534
s.dist 0.509
p.adjustANOVA 0.0265



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gab1 7496
Fgf1 7466
Pik3ca 6278
Fgf2 5927
Frs2 4435
Fgf9 4376
Fgf18 3657
Ptpn11 3576
Grb2 1153
Pik3r1 -3938

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gab1 7496
Fgf1 7466
Pik3ca 6278
Fgf2 5927
Frs2 4435
Fgf9 4376
Fgf18 3657
Ptpn11 3576
Grb2 1153
Pik3r1 -3938


RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
832
set RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize 125
pANOVA 2.14e-22
s.dist 0.504
p.adjustANOVA 5e-20



Top enriched genes

Top 20 genes
GeneID Gene Rank
Coq10b 8017
Ndufb5 7944
Atp5b 7926
Ndufv2 7897
Ndufc1 7879
mt-Co1 7877
Ndufaf4 7875
Atp5a1 7859
mt-Nd4 7791
Cox7a2l 7766
Sdhc 7740
mt-Nd3 7696
mt-Nd6 7692
Atp5c1 7595
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
mt-Co2 7495

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Coq10b 8017
Ndufb5 7944
Atp5b 7926
Ndufv2 7897
Ndufc1 7879
mt-Co1 7877
Ndufaf4 7875
Atp5a1 7859
mt-Nd4 7791
Cox7a2l 7766
Sdhc 7740
mt-Nd3 7696
mt-Nd6 7692
Atp5c1 7595
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
mt-Co2 7495
Ndufa10 7480
mt-Nd2 7440
mt-Cytb 7410
Timmdc1 7361
Cycs 7344
Uqcrb 7297
mt-Co3 7283
Atp5pb 7221
Ndufaf1 7140
Ndufa5 7111
Cox5a 7096
Surf1 7002
Ndufa4 6926
Slc25a14 6823
Ndufb9 6752
Ucp2 6710
Ndufaf6 6597
Ndufb4 6558
mt-Atp6 6538
Cox6a1 6525
Ndufb11 6478
mt-Atp8 6392
Ndufs1 6380
Ndufaf2 6187
Ndufb8 6186
Atp5h 6054
Sco2 6002
Ndufs3 6000
Ndufa13 5845
Cox7c 5828
Ndufaf5 5684
Ndufab1 5620
Uqcrc2 5490
Coq10a 5363
Cox20 5321
Cox5b 5286
Sdha 5219
Sdhd 5008
Taco1 4975
Cox6c 4919
Ndufc2 4815
Ndufa6 4771
Pm20d1 4760
Cox16 4725
Ndufs5 4712
Cox8a 4557
Ndufa7 4534
Cox7b 4523
Sdhb 4460
Uqcrq 4400
Atp5g3 4195
Cox18 4186
Ndufb6 4184
Ucp3 4013
Atp5o 3980
Uqcrfs1 3896
Ndufs6 3839
Atp5j 3778
Ndufv1 3473
Ndufb1 3424
Uqcrh 3303
Tmem126b 3234
Etfa 3125
Ndufa1 2822
Dmac2l 2813
Ndufb3 2499
Ecsit 2347
Cyc1 2327
Ndufs7 2105
Etfb 2001
Acad9 1990
Atp5d 1771
Cox6b1 1748
Atp5l 1715
Ndufa8 1700
Atp5j2 1380
Ndufb7 1370
Atp5e 1326
Ndufb2 1235
Etfdh 1105
Atp5g1 1065
Uqcr10 944
Uqcrc1 825
Cox4i1 421
Atp5k 361
Ndufs8 350
Ndufb10 315
Ndufv3 202
Sco1 89
Nubpl 24
Ndufa3 -187
Trap1 -275
Uqcr11 -884
Ndufa11 -921
Ndufaf3 -1144
Ndufa9 -1155
Ndufaf7 -1201
Ndufa2 -1362
Cox14 -2274
Atp5g2 -3018
Cox19 -4424
Slc25a27 -6531
Lrpprc -6913
Cox11 -7075
Tmem186 -7244


PLATELET SENSITIZATION BY LDL

PLATELET SENSITIZATION BY LDL
718
set PLATELET SENSITIZATION BY LDL
setSize 15
pANOVA 0.000766
s.dist 0.502
p.adjustANOVA 0.0058



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp2cb 7900
Ppp2r5a 7827
Ppp2r5b 7715
Pla2g4a 7167
Pecam1 6291
Ppp2r5c 6221
Ppp2r5d 6074
Ppp2ca 6007
Ppp2r5e 5885
Ppp2r1a 5784
Ptpn6 5291
Ptpn11 3576
Ppp2r1b -3518
Mapk14 -4076
Lrp8 -8388

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2cb 7900
Ppp2r5a 7827
Ppp2r5b 7715
Pla2g4a 7167
Pecam1 6291
Ppp2r5c 6221
Ppp2r5d 6074
Ppp2ca 6007
Ppp2r5e 5885
Ppp2r1a 5784
Ptpn6 5291
Ptpn11 3576
Ppp2r1b -3518
Mapk14 -4076
Lrp8 -8388


FRS MEDIATED FGFR3 SIGNALING

FRS MEDIATED FGFR3 SIGNALING
343
set FRS MEDIATED FGFR3 SIGNALING
setSize 14
pANOVA 0.00121
s.dist 0.5
p.adjustANOVA 0.00822



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fgfr3 7898
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Frs2 4435
Fgf9 4376
Nras 3869
Fgf18 3657
Ptpn11 3576
Frs3 2469
Grb2 1153
Sos1 677
Fgf5 -1717

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fgfr3 7898
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Frs2 4435
Fgf9 4376
Nras 3869
Fgf18 3657
Ptpn11 3576
Frs3 2469
Grb2 1153
Sos1 677
Fgf5 -1717


SIGNALING BY FGFR3 FUSIONS IN CANCER

SIGNALING BY FGFR3 FUSIONS IN CANCER
950
set SIGNALING BY FGFR3 FUSIONS IN CANCER
setSize 10
pANOVA 0.00628
s.dist 0.499
p.adjustANOVA 0.0303



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fgfr3 7898
Gab1 7496
Pik3ca 6278
Hras 6143
Kras 5612
Frs2 4435
Nras 3869
Grb2 1153
Sos1 677
Pik3r1 -3938

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fgfr3 7898
Gab1 7496
Pik3ca 6278
Hras 6143
Kras 5612
Frs2 4435
Nras 3869
Grb2 1153
Sos1 677
Pik3r1 -3938


SHC MEDIATED CASCADE FGFR3

SHC MEDIATED CASCADE FGFR3
920
set SHC MEDIATED CASCADE FGFR3
setSize 12
pANOVA 0.00296
s.dist 0.496
p.adjustANOVA 0.0169



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fgfr3 7898
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Fgf9 4376
Nras 3869
Fgf18 3657
Shc1 2132
Grb2 1153
Sos1 677
Fgf5 -1717

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fgfr3 7898
Fgf1 7466
Hras 6143
Fgf2 5927
Kras 5612
Fgf9 4376
Nras 3869
Fgf18 3657
Shc1 2132
Grb2 1153
Sos1 677
Fgf5 -1717


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
1028
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 4.08e-06
s.dist 0.494
p.adjustANOVA 8.5e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ube2r2 8020
Ube2g1 7707
Ube2l3 7106
Ube2a 6534
Rps27a 6287
Ube2d2a 6130
Ube2d1 5982
Ube2e3 5806
Otulin 5552
Ube2e1 5415
Ube2q2 5320
Ube2w 5304
Ube2b 5258
Usp9x 4842
Uba52 4679
Uba6 4674
Ubb 4462
Ube2z 4172
Cdc34 3659
Uchl3 3250

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2r2 8020
Ube2g1 7707
Ube2l3 7106
Ube2a 6534
Rps27a 6287
Ube2d2a 6130
Ube2d1 5982
Ube2e3 5806
Otulin 5552
Ube2e1 5415
Ube2q2 5320
Ube2w 5304
Ube2b 5258
Usp9x 4842
Uba52 4679
Uba6 4674
Ubb 4462
Ube2z 4172
Cdc34 3659
Uchl3 3250
Ube2h 2615
Usp5 2451
Ube2k 2135
Ube2s 840
Uba1 320
Ubc -674
Ube2t -678
Usp7 -1723
Ube2g2 -1824


BLOOD GROUP SYSTEMS BIOSYNTHESIS

BLOOD GROUP SYSTEMS BIOSYNTHESIS
101
set BLOOD GROUP SYSTEMS BIOSYNTHESIS
setSize 13
pANOVA 0.00206
s.dist 0.494
p.adjustANOVA 0.0129



Top enriched genes

Top 20 genes
GeneID Gene Rank
St3gal4 8093
B3galt5 6528
B3galt2 6470
St3gal6 5385
B3galt1 5293
Fut9 5234
Fut11 4673
Fut10 3978
St6galnac6 3150
Fut2 2113
St3gal3 1139
Fut4 841
B3galt4 -1984

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
St3gal4 8093
B3galt5 6528
B3galt2 6470
St3gal6 5385
B3galt1 5293
Fut9 5234
Fut11 4673
Fut10 3978
St6galnac6 3150
Fut2 2113
St3gal3 1139
Fut4 841
B3galt4 -1984


SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
1005
set SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize 106
pANOVA 2.77e-18
s.dist 0.49
p.adjustANOVA 3.59e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
Spcs1 7967
Rps25 7858
Rps9 7627
Ssr3 7589
Rpl23a 7569
Rpl24 7540
Rps27l 7476
Rps8 7351
Srp72 7263
Rps3a1 7090
Srp54a 7056
Rpl22l1 6945
Sec11c 6816
Rps23 6815
Rpl6 6753
Rps4x 6720
Srpr 6582
Rpl23 6522
Rps24 6391
Rps7 6301

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs1 7967
Rps25 7858
Rps9 7627
Ssr3 7589
Rpl23a 7569
Rpl24 7540
Rps27l 7476
Rps8 7351
Srp72 7263
Rps3a1 7090
Srp54a 7056
Rpl22l1 6945
Sec11c 6816
Rps23 6815
Rpl6 6753
Rps4x 6720
Srpr 6582
Rpl23 6522
Rps24 6391
Rps7 6301
Rps27a 6287
Rpl37a 6189
Rpl4 6147
Rpl13a 6123
Ddost 6104
Spcs3 6039
Rpl5 6038
Rpl3 5935
Rplp0 5890
Rpl22 5876
Rps29 5797
Fau 5746
Rpl31 5692
Srp9 5648
Rpl17 5602
Rpl14 5533
Rps18 5494
Rpl35a 5482
Spcs2 5471
Srprb 5458
Rps20 5420
Rpl18a 5350
Rps19 5329
Rpl11 5300
Rps26 5233
Rpl27 5209
Rpl30 5196
Rpl9 5140
Ssr1 5034
Rpl7 5019
Rps5 4949
Rpl39 4872
Uba52 4679
Rpl32 4626
Rpl35 4264
Srp19 4114
Ssr2 4052
Rpl36a 4037
Rpl38 3999
Rps28 3895
Srp14 3836
Rpl29 3662
Rpl26 3633
Rpl19 3567
Rps11 3518
Rpl34 3514
Rpn2 3270
Rpl13 3236
Sec61g 3229
Rps21 3188
Rpsa 3113
Rpl15 3020
Rpl37 2953
Rpl27a 2791
Rps17 2734
Rpl21 2678
Rpl8 2675
Rpn1 2597
Tram1 2538
Rpl7a 2288
Rps27 2204
Rps13 2150
Sec61b 2098
Rps6 2046
Rps16 1905
Rpl36al 1812
Rps2 1413
Rps3 1378
Rps10 1099
Rpl28 833
Sec11a 819
Rplp2 775
Rpl10a 728
Rps15 684
Rpl18 262
Ssr4 -81
Rps15a -368
Rpl36 -379
Rps12 -530
Rplp1 -556
Srp68 -977
Rps14 -1429
Rpl10 -3715
Sec61a1 -5469
Sec61a2 -6158
Rpl12 -7475


PI 3K CASCADE FGFR3

PI 3K CASCADE FGFR3
699
set PI 3K CASCADE FGFR3
setSize 12
pANOVA 0.00331
s.dist 0.49
p.adjustANOVA 0.0182



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fgfr3 7898
Gab1 7496
Fgf1 7466
Pik3ca 6278
Fgf2 5927
Frs2 4435
Fgf9 4376
Fgf18 3657
Ptpn11 3576
Grb2 1153
Fgf5 -1717
Pik3r1 -3938

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fgfr3 7898
Gab1 7496
Fgf1 7466
Pik3ca 6278
Fgf2 5927
Frs2 4435
Fgf9 4376
Fgf18 3657
Ptpn11 3576
Grb2 1153
Fgf5 -1717
Pik3r1 -3938


TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
1116
set TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
setSize 15
pANOVA 0.00113
s.dist 0.486
p.adjustANOVA 0.00783



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sox2 7746
Smad4 6985
Hhex 6617
Hif3a 6505
Sall1 6354
Klf4 5974
Fgf2 5927
Epas1 3990
Stat3 3875
Tsc22d1 3290
Smad2 3119
Foxp1 2381
Pbx1 579
Zic3 417
Nr6a1 -6007

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sox2 7746
Smad4 6985
Hhex 6617
Hif3a 6505
Sall1 6354
Klf4 5974
Fgf2 5927
Epas1 3990
Stat3 3875
Tsc22d1 3290
Smad2 3119
Foxp1 2381
Pbx1 579
Zic3 417
Nr6a1 -6007


RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
856
set RHOBTB3 ATPASE CYCLE
setSize 10
pANOVA 0.00805
s.dist 0.484
p.adjustANOVA 0.037



Top enriched genes

Top 20 genes
GeneID Gene Rank
Plin3 7871
Rhobtb3 7502
Cul3 7450
Rab9 6893
Vhl 5231
Rab9b 4732
Lrrc41 2739
Htr7 2253
Hgs 613
Ccne1 -6917

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plin3 7871
Rhobtb3 7502
Cul3 7450
Rab9 6893
Vhl 5231
Rab9b 4732
Lrrc41 2739
Htr7 2253
Hgs 613
Ccne1 -6917


FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
326
set FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize 18
pANOVA 0.000384
s.dist 0.483
p.adjustANOVA 0.00332



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5b 7926
Atp5a1 7859
Atp5c1 7595
Atp5pb 7221
mt-Atp6 6538
mt-Atp8 6392
Atp5h 6054
Atp5g3 4195
Atp5o 3980
Atp5j 3778
Dmac2l 2813
Atp5d 1771
Atp5l 1715
Atp5j2 1380
Atp5e 1326
Atp5g1 1065
Atp5k 361
Atp5g2 -3018

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5b 7926
Atp5a1 7859
Atp5c1 7595
Atp5pb 7221
mt-Atp6 6538
mt-Atp8 6392
Atp5h 6054
Atp5g3 4195
Atp5o 3980
Atp5j 3778
Dmac2l 2813
Atp5d 1771
Atp5l 1715
Atp5j2 1380
Atp5e 1326
Atp5g1 1065
Atp5k 361
Atp5g2 -3018


ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
27
set ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
setSize 59
pANOVA 1.91e-10
s.dist 0.479
p.adjustANOVA 1.01e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rps27l 7476
Eif2s2 7384
Eif2s1 7376
Rps8 7351
Eif3j2 7325
Eif2s3x 7320
Rps3a1 7090
Eif3e 6908
Eif3m 6834
Rps23 6815
Rps4x 6720
Eif4e 6693
Pabpc1 6473
Rps24 6391
Rps7 6301
Rps27a 6287
Eif4a2 5815
Rps29 5797

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rps27l 7476
Eif2s2 7384
Eif2s1 7376
Rps8 7351
Eif3j2 7325
Eif2s3x 7320
Rps3a1 7090
Eif3e 6908
Eif3m 6834
Rps23 6815
Rps4x 6720
Eif4e 6693
Pabpc1 6473
Rps24 6391
Rps7 6301
Rps27a 6287
Eif4a2 5815
Rps29 5797
Eif3f 5750
Fau 5746
Rps18 5494
Rps20 5420
Eif3h 5368
Rps19 5329
Rps26 5233
Rps5 4949
Eif4b 4222
Eif3g 4201
Rps28 3895
Eif1ax 3743
Eif3l 3734
Rps11 3518
Rps21 3188
Eif4ebp1 3184
Rpsa 3113
Eif3c 2740
Rps17 2734
Eif3i 2278
Eif4a1 2227
Rps27 2204
Rps13 2150
Rps6 2046
Rps16 1905
Eif3b 1735
Rps2 1413
Rps3 1378
Rps10 1099
Rps15 684
Eif3j1 347
Eif3d 142
Rps15a -368
Rps12 -530
Eif4h -1077
Eif3k -1122
Rps14 -1429
Eif3a -4675
Eif4g1 -6404


ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
81
set ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
setSize 10
pANOVA 0.00908
s.dist 0.476
p.adjustANOVA 0.0411



Top enriched genes

Top 20 genes
GeneID Gene Rank
Xbp1 7923
Calr 7910
Hspa5 7749
Nfyc 6772
Hsp90b1 6318
Nfyb 4927
Ddit3 4261
Atf6 1166
Atf4 -2106
Nfya -7169

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Xbp1 7923
Calr 7910
Hspa5 7749
Nfyc 6772
Hsp90b1 6318
Nfyb 4927
Ddit3 4261
Atf6 1166
Atf4 -2106
Nfya -7169


FATTY ACYL COA BIOSYNTHESIS

FATTY ACYL COA BIOSYNTHESIS
311
set FATTY ACYL COA BIOSYNTHESIS
setSize 32
pANOVA 3.15e-06
s.dist 0.476
p.adjustANOVA 6.8e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Elovl1 8118
Scd2 8076
Scd1 7997
Hsd17b12 7866
Elovl5 7774
Hacd3 7769
Acsbg1 7556
Acsl3 7541
Hacd1 7417
Hacd2 7201
Elovl4 6855
Ppt1 6205
Slc25a1 6125
Acsl4 5771
Elovl2 5586
Tecr 4330
Acsl1 4281
Acly 3707
Elovl7 3641
Acsl6 3624

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elovl1 8118
Scd2 8076
Scd1 7997
Hsd17b12 7866
Elovl5 7774
Hacd3 7769
Acsbg1 7556
Acsl3 7541
Hacd1 7417
Hacd2 7201
Elovl4 6855
Ppt1 6205
Slc25a1 6125
Acsl4 5771
Elovl2 5586
Tecr 4330
Acsl1 4281
Acly 3707
Elovl7 3641
Acsl6 3624
Cbr4 3571
Rpp14 3562
H2-Ke6 2048
Elovl6 1439
Fasn 1074
Ppt2 712
Acaca 149
Hacd4 -253
Acsl5 -955
Slc27a3 -5087
Acsf3 -5411
Morc2a -7767


FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES

FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES
337
set FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES
setSize 17
pANOVA 0.000716
s.dist 0.474
p.adjustANOVA 0.00557



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cav1 8035
Btg1 8014
Smad4 6985
Mstn 6803
Cdkn1b 6120
Klf4 5974
Ccng2 5735
Rbl2 5403
Foxg1 5259
Foxo1 4366
Smad3 3892
Smad2 3119
Pcbp4 3011
Foxo3 1080
Gadd45a -2055
Foxo4 -3211
Cdkn1a -4735

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cav1 8035
Btg1 8014
Smad4 6985
Mstn 6803
Cdkn1b 6120
Klf4 5974
Ccng2 5735
Rbl2 5403
Foxg1 5259
Foxo1 4366
Smad3 3892
Smad2 3119
Pcbp4 3011
Foxo3 1080
Gadd45a -2055
Foxo4 -3211
Cdkn1a -4735


EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION
303
set EUKARYOTIC TRANSLATION INITIATION
setSize 114
pANOVA 2.33e-18
s.dist 0.474
p.adjustANOVA 3.4e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rpl23a 7569
Rpl24 7540
Rps27l 7476
Eif2s2 7384
Eif2s1 7376
Rps8 7351
Eif3j2 7325
Eif2s3x 7320
Rps3a1 7090
Rpl22l1 6945
Eif3e 6908
Eif3m 6834
Rps23 6815
Rpl6 6753
Rps4x 6720
Eif4e 6693
Rpl23 6522
Pabpc1 6473

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rpl23a 7569
Rpl24 7540
Rps27l 7476
Eif2s2 7384
Eif2s1 7376
Rps8 7351
Eif3j2 7325
Eif2s3x 7320
Rps3a1 7090
Rpl22l1 6945
Eif3e 6908
Eif3m 6834
Rps23 6815
Rpl6 6753
Rps4x 6720
Eif4e 6693
Rpl23 6522
Pabpc1 6473
Rps24 6391
Rps7 6301
Rps27a 6287
Rpl37a 6189
Rpl4 6147
Rpl13a 6123
Rpl5 6038
Rpl3 5935
Rplp0 5890
Rpl22 5876
Eif4a2 5815
Rps29 5797
Eif3f 5750
Fau 5746
Rpl31 5692
Rpl17 5602
Rpl14 5533
Rps18 5494
Rpl35a 5482
Eif5b 5446
Rps20 5420
Eif3h 5368
Rpl18a 5350
Rps19 5329
Rpl11 5300
Rps26 5233
Rpl27 5209
Rpl30 5196
Rpl9 5140
Rpl7 5019
Rps5 4949
Eif5 4917
Rpl39 4872
Uba52 4679
Rpl32 4626
Eif2b2 4507
Rpl35 4264
Eif4b 4222
Eif3g 4201
Rpl36a 4037
Rpl38 3999
Rps28 3895
Eif1ax 3743
Eif3l 3734
Rpl29 3662
Rpl26 3633
Rpl19 3567
Rps11 3518
Rpl34 3514
Eif2b5 3325
Rpl13 3236
Rps21 3188
Eif4ebp1 3184
Rpsa 3113
Rpl15 3020
Eif2b4 3006
Rpl37 2953
Rpl27a 2791
Eif3c 2740
Rps17 2734
Rpl21 2678
Rpl8 2675
Rpl7a 2288
Eif3i 2278
Eif4a1 2227
Rps27 2204
Rps13 2150
Rps6 2046
Rps16 1905
Rpl36al 1812
Eif3b 1735
Rps2 1413
Rps3 1378
Rps10 1099
Rpl28 833
Rplp2 775
Rpl10a 728
Rps15 684
Eif3j1 347
Rpl18 262
Eif3d 142
Rps15a -368
Rpl36 -379
Rps12 -530
Rplp1 -556
Eif4h -1077
Eif3k -1122
Eif2b3 -1343
Rps14 -1429
Eif2b1 -2155
Rpl10 -3715
Eif3a -4675
Eif4g1 -6404
Rpl12 -7475


PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR

PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR
746
set PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR
setSize 16
pANOVA 0.00105
s.dist 0.473
p.adjustANOVA 0.0075



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng12 7806
Gng10 7124
Gng5 7046
Gnb5 6692
Gng11 6628
Gng7 5129
Gng3 4233
Gngt2 2842
Gnb4 2642
Gng8 2077
Gng4 2019
Gng2 1559
Gnb2 1365
Gnas 1269
Gng13 921
Gnb1 594

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng12 7806
Gng10 7124
Gng5 7046
Gnb5 6692
Gng11 6628
Gng7 5129
Gng3 4233
Gngt2 2842
Gnb4 2642
Gng8 2077
Gng4 2019
Gng2 1559
Gnb2 1365
Gnas 1269
Gng13 921
Gnb1 594


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
45
set ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize 12
pANOVA 0.00471
s.dist 0.471
p.adjustANOVA 0.0243



Top enriched genes

Top 20 genes
GeneID Gene Rank
Elovl1 8118
Elovl5 7774
Scp2 7637
Hsd17b4 7396
Elovl2 5586
Acox1 5292
Fads2 4736
Acsl1 4281
Fads1 4276
Acot8 -1056
Abcd1 -2475
Acaa1a -6796

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elovl1 8118
Elovl5 7774
Scp2 7637
Hsd17b4 7396
Elovl2 5586
Acox1 5292
Fads2 4736
Acsl1 4281
Fads1 4276
Acot8 -1056
Abcd1 -2475
Acaa1a -6796


RAS PROCESSING

RAS PROCESSING
774
set RAS PROCESSING
setSize 23
pANOVA 9.45e-05
s.dist 0.47
p.adjustANOVA 0.000989



Top enriched genes

Top 20 genes
GeneID Gene Rank
Abhd17b 7891
Abhd17c 7874
Golga7 7400
Fnta 7322
Zdhhc9 6874
Bcl2l1 6711
Rps27a 6287
Hras 6143
Lypla1 5859
Kras 5612
Pde6d 5591
Calm1 5542
Uba52 4679
Ubb 4462
Abhd17a 4110
Nras 3869
Prkcq 3124
Prkg2 2320
Ubc -674
Fntb -1258

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Abhd17b 7891
Abhd17c 7874
Golga7 7400
Fnta 7322
Zdhhc9 6874
Bcl2l1 6711
Rps27a 6287
Hras 6143
Lypla1 5859
Kras 5612
Pde6d 5591
Calm1 5542
Uba52 4679
Ubb 4462
Abhd17a 4110
Nras 3869
Prkcq 3124
Prkg2 2320
Ubc -674
Fntb -1258
Arl2 -2069
Rce1 -4926
Icmt -7173


THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
1060
set THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
setSize 172
pANOVA 2.15e-26
s.dist 0.47
p.adjustANOVA 8.35e-24



Top enriched genes

Top 20 genes
GeneID Gene Rank
Coq10b 8017
Pdk3 7973
Ndufb5 7944
Atp5b 7926
Ndufv2 7897
Idh3a 7890
Ndufc1 7879
mt-Co1 7877
Ndufaf4 7875
Atp5a1 7859
mt-Nd4 7791
Cox7a2l 7766
Sdhc 7740
mt-Nd3 7696
mt-Nd6 7692
Dlat 7600
Atp5c1 7595
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Coq10b 8017
Pdk3 7973
Ndufb5 7944
Atp5b 7926
Ndufv2 7897
Idh3a 7890
Ndufc1 7879
mt-Co1 7877
Ndufaf4 7875
Atp5a1 7859
mt-Nd4 7791
Cox7a2l 7766
Sdhc 7740
mt-Nd3 7696
mt-Nd6 7692
Dlat 7600
Atp5c1 7595
mt-Nd1 7590
Ndufa12 7566
Ndufs4 7517
Ndufs2 7516
mt-Nd5 7514
mt-Co2 7495
Ndufa10 7480
mt-Nd2 7440
mt-Cytb 7410
Timmdc1 7361
Cycs 7344
Uqcrb 7297
mt-Co3 7283
Pdha1 7264
Atp5pb 7221
Mpc1 7215
Ndufaf1 7140
Ndufa5 7111
Cox5a 7096
Suclg2 7068
Surf1 7002
Ndufa4 6926
Sucla2 6894
Slc25a14 6823
Ndufb9 6752
Glo1 6716
Ucp2 6710
Ndufaf6 6597
Nnt 6565
Ndufb4 6558
mt-Atp6 6538
Cox6a1 6525
Ndufb11 6478
mt-Atp8 6392
Ndufs1 6380
Rxra 6289
Idh2 6267
Ndufaf2 6187
Ndufb8 6186
Atp5h 6054
Sco2 6002
Ndufs3 6000
Pdk4 5986
Ldhb 5921
Vdac1 5870
Ndufa13 5845
Pdp1 5830
Cox7c 5828
Me1 5757
Ndufaf5 5684
Ndufab1 5620
Uqcrc2 5490
Coq10a 5363
Mpc2 5346
Cox20 5321
Suclg1 5310
Cox5b 5286
Sdha 5219
Fh1 5176
Pdhb 5141
Sdhd 5008
Cs 4980
Taco1 4975
Cox6c 4919
Pdhx 4836
Ndufc2 4815
Ndufa6 4771
Pm20d1 4760
Cox16 4725
Ndufs5 4712
Dld 4601
Cox8a 4557
Ndufa7 4534
Cox7b 4523
Adhfe1 4469
Sdhb 4460
Uqcrq 4400
Aco2 4210
Atp5g3 4195
Cox18 4186
Ndufb6 4184
Slc16a1 4038
Ucp3 4013
Atp5o 3980
Uqcrfs1 3896
Ndufs6 3839
Ogdh 3795
Atp5j 3778
Mdh2 3695
Ndufv1 3473
Me2 3460
Ndufb1 3424
Bsg 3344
Uqcrh 3303
Ppard 3261
Tmem126b 3234
Etfa 3125
Ndufa1 2822
Dmac2l 2813
Ndufb3 2499
Ecsit 2347
Cyc1 2327
Ndufs7 2105
Etfb 2001
Acad9 1990
Atp5d 1771
Cox6b1 1748
Atp5l 1715
Ndufa8 1700
Hagh 1628
Fahd1 1568
Atp5j2 1380
Ndufb7 1370
Atp5e 1326
Ndufb2 1235
Etfdh 1105
Atp5g1 1065
Uqcr10 944
Uqcrc1 825
Cox4i1 421
Atp5k 361
Ndufs8 350
Pdk2 329
Ndufb10 315
Ndufv3 202
Sco1 89
Me3 55
Nubpl 24
Ldha -113
Ndufa3 -187
Trap1 -275
Dlst -353
Uqcr11 -884
Ndufa11 -921
Ndufaf3 -1144
D2hgdh -1145
Ndufa9 -1155
Ndufaf7 -1201
Ndufa2 -1362
L2hgdh -1916
Slc16a3 -1977
Idh3g -2178
Cox14 -2274
Idh3b -2457
Pdpr -2918
Atp5g2 -3018
Gstz1 -4290
Cox19 -4424
Slc25a27 -6531
Lrpprc -6913
Pdp2 -6928
Cox11 -7075
Tmem186 -7244
Slc16a8 -7493
Pdk1 -8282


GLYCOGEN SYNTHESIS

GLYCOGEN SYNTHESIS
387
set GLYCOGEN SYNTHESIS
setSize 14
pANOVA 0.00242
s.dist 0.468
p.adjustANOVA 0.0145



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pgm1 8125
Ugp2 7604
Gbe1 7449
Gyg 7282
Rps27a 6287
Nhlrc1 5027
Ppp1r3c 4989
Uba52 4679
Ubb 4462
Gys1 3094
Pgm2 724
Pgm2l1 -550
Ubc -674
Epm2a -6621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pgm1 8125
Ugp2 7604
Gbe1 7449
Gyg 7282
Rps27a 6287
Nhlrc1 5027
Ppp1r3c 4989
Uba52 4679
Ubb 4462
Gys1 3094
Pgm2 724
Pgm2l1 -550
Ubc -674
Epm2a -6621


RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
834
set RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize 94
pANOVA 4.97e-15
s.dist 0.467
p.adjustANOVA 4.46e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rpl23a 7569
Rpl24 7540
Asns 7504
Rps27l 7476
Eif2s2 7384
Eif2s1 7376
Rps8 7351
Eif2s3x 7320
Rps3a1 7090
Rpl22l1 6945
Rps23 6815
Rpl6 6753
Rps4x 6720
Rpl23 6522
Rps24 6391
Rps7 6301
Rps27a 6287
Rpl37a 6189

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps25 7858
Rps9 7627
Rpl23a 7569
Rpl24 7540
Asns 7504
Rps27l 7476
Eif2s2 7384
Eif2s1 7376
Rps8 7351
Eif2s3x 7320
Rps3a1 7090
Rpl22l1 6945
Rps23 6815
Rpl6 6753
Rps4x 6720
Rpl23 6522
Rps24 6391
Rps7 6301
Rps27a 6287
Rpl37a 6189
Rpl4 6147
Rpl13a 6123
Rpl5 6038
Rpl3 5935
Rplp0 5890
Rpl22 5876
Rps29 5797
Fau 5746
Rpl31 5692
Rpl17 5602
Impact 5553
Rpl14 5533
Rps18 5494
Rpl35a 5482
Rps20 5420
Rpl18a 5350
Rps19 5329
Rpl11 5300
Rps26 5233
Rpl27 5209
Rpl30 5196
Rpl9 5140
Rpl7 5019
Rps5 4949
Rpl39 4872
Uba52 4679
Rpl32 4626
Cebpb 4517
Rpl35 4264
Ddit3 4261
Rpl36a 4037
Rpl38 3999
Rps28 3895
Rpl29 3662
Rpl26 3633
Rpl19 3567
Rps11 3518
Rpl34 3514
Rpl13 3236
Rps21 3188
Rpsa 3113
Rpl15 3020
Rpl37 2953
Rpl27a 2791
Rps17 2734
Rpl21 2678
Rpl8 2675
Rpl7a 2288
Rps27 2204
Rps13 2150
Rps6 2046
Rps16 1905
Rpl36al 1812
Atf2 1701
Rps2 1413
Rps3 1378
Rps10 1099
Rpl28 833
Rplp2 775
Rpl10a 728
Rps15 684
Cebpg 649
Rpl18 262
Rps15a -368
Rpl36 -379
Rps12 -530
Rplp1 -556
Atf3 -1131
Rps14 -1429
Atf4 -2106
Rpl10 -3715
Rpl12 -7475
Gcn1 -7718
Eif2ak4 -8362


METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION

METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION
547
set METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION
setSize 15
pANOVA 0.00197
s.dist 0.462
p.adjustANOVA 0.0124



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cav1 8035
Ddah1 7708
Wasl 7633
Cygb 5958
Lypla1 5859
Hsp90aa1 5561
Calm1 5542
Nostrin 5529
Ddah2 5412
Akt1 1895
Dnm2 1477
Nosip 1160
Spr 474
Nos3 164
Zdhhc21 -7662

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cav1 8035
Ddah1 7708
Wasl 7633
Cygb 5958
Lypla1 5859
Hsp90aa1 5561
Calm1 5542
Nostrin 5529
Ddah2 5412
Akt1 1895
Dnm2 1477
Nosip 1160
Spr 474
Nos3 164
Zdhhc21 -7662


G BETA GAMMA SIGNALLING THROUGH CDC42

G BETA GAMMA SIGNALLING THROUGH CDC42
350
set G BETA GAMMA SIGNALLING THROUGH CDC42
setSize 18
pANOVA 0.000775
s.dist 0.458
p.adjustANOVA 0.0058



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng12 7806
Gng10 7124
Gng5 7046
Gnb5 6692
Gng11 6628
Cdc42 6360
Gng7 5129
Pak1 4487
Gng3 4233
Gngt2 2842
Gnb4 2642
Gng8 2077
Gng4 2019
Gng2 1559
Gnb2 1365
Gng13 921
Gnb1 594
Arhgef6 -4422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng12 7806
Gng10 7124
Gng5 7046
Gnb5 6692
Gng11 6628
Cdc42 6360
Gng7 5129
Pak1 4487
Gng3 4233
Gngt2 2842
Gnb4 2642
Gng8 2077
Gng4 2019
Gng2 1559
Gnb2 1365
Gng13 921
Gnb1 594
Arhgef6 -4422


METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS

METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS
541
set METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS
setSize 10
pANOVA 0.0123
s.dist 0.457
p.adjustANOVA 0.0523



Top enriched genes

Top 20 genes
GeneID Gene Rank
Agt 7606
Ctsd 7188
Atp6ap2 6697
Ctsz 6129
Anpep 6059
Ace2 5655
Ace 4117
Mme 3650
Enpep -4525
Aopep -6417

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Agt 7606
Ctsd 7188
Atp6ap2 6697
Ctsz 6129
Anpep 6059
Ace2 5655
Ace 4117
Mme 3650
Enpep -4525
Aopep -6417


GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
386
set GLYCOGEN STORAGE DISEASES
setSize 12
pANOVA 0.00647
s.dist 0.454
p.adjustANOVA 0.0311



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gbe1 7449
Gyg 7282
Rps27a 6287
Nhlrc1 5027
Ppp1r3c 4989
Uba52 4679
Ubb 4462
Gaa 3614
G6pc3 3464
Gys1 3094
Ubc -674
Epm2a -6621

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gbe1 7449
Gyg 7282
Rps27a 6287
Nhlrc1 5027
Ppp1r3c 4989
Uba52 4679
Ubb 4462
Gaa 3614
G6pc3 3464
Gys1 3094
Ubc -674
Epm2a -6621


CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT

CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
158
set CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
setSize 20
pANOVA 0.000442
s.dist 0.454
p.adjustANOVA 0.00368



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc25a17 8077
Pex2 7870
Atad1 7415
Abcd3 7379
Pex13 7006
Fis1 7005
Pex19 6866
Abcd2 6373
Gdap1 4773
Acbd5 4665
Pxmp2 3668
Aldh3a2 3588
Pex11b 3172
Pex3 1834
Pex12 1617
Pxmp4 1131
Pex14 -1275
Pex16 -1370
Abcd1 -2475
Pex26 -5619

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc25a17 8077
Pex2 7870
Atad1 7415
Abcd3 7379
Pex13 7006
Fis1 7005
Pex19 6866
Abcd2 6373
Gdap1 4773
Acbd5 4665
Pxmp2 3668
Aldh3a2 3588
Pex11b 3172
Pex3 1834
Pex12 1617
Pxmp4 1131
Pex14 -1275
Pex16 -1370
Abcd1 -2475
Pex26 -5619


PROTEIN METHYLATION

PROTEIN METHYLATION
749
set PROTEIN METHYLATION
setSize 17
pANOVA 0.00124
s.dist 0.452
p.adjustANOVA 0.00839



Top enriched genes

Top 20 genes
GeneID Gene Rank
Vcp 7130
Eef1a1 7063
Camkmt 5732
Kin 5704
Calm1 5542
Hspa8 5342
Eef2 5248
Prmt3 5086
Eef1akmt1 4898
Eef1akmt2 3787
Mettl21a 3585
Etfb 2001
Rps2 1413
Mettl22 1306
Vcpkmt 181
Etfbkmt -988
Eef2kmt -2295

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Vcp 7130
Eef1a1 7063
Camkmt 5732
Kin 5704
Calm1 5542
Hspa8 5342
Eef2 5248
Prmt3 5086
Eef1akmt1 4898
Eef1akmt2 3787
Mettl21a 3585
Etfb 2001
Rps2 1413
Mettl22 1306
Vcpkmt 181
Etfbkmt -988
Eef2kmt -2295


SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
1030
set SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
setSize 12
pANOVA 0.00693
s.dist 0.45
p.adjustANOVA 0.0326



Top enriched genes

Top 20 genes
GeneID Gene Rank
Scp2 7637
Hsd3b7 7511
Hsd17b4 7396
Rxra 6289
Ptgis 6078
Cyp7b1 4727
Cyp27a1 4437
Slc27a2 2607
Amacr 2242
Acot8 -1056
Ncoa2 -2259
Ncoa1 -2932

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Scp2 7637
Hsd3b7 7511
Hsd17b4 7396
Rxra 6289
Ptgis 6078
Cyp7b1 4727
Cyp27a1 4437
Slc27a2 2607
Amacr 2242
Acot8 -1056
Ncoa2 -2259
Ncoa1 -2932


ENOS ACTIVATION

ENOS ACTIVATION
283
set ENOS ACTIVATION
setSize 11
pANOVA 0.01
s.dist 0.448
p.adjustANOVA 0.0444



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cav1 8035
Ddah1 7708
Cygb 5958
Lypla1 5859
Hsp90aa1 5561
Calm1 5542
Ddah2 5412
Akt1 1895
Spr 474
Nos3 164
Zdhhc21 -7662

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cav1 8035
Ddah1 7708
Cygb 5958
Lypla1 5859
Hsp90aa1 5561
Calm1 5542
Ddah2 5412
Akt1 1895
Spr 474
Nos3 164
Zdhhc21 -7662


DARPP 32 EVENTS

DARPP 32 EVENTS
207
set DARPP 32 EVENTS
setSize 23
pANOVA 0.000228
s.dist 0.444
p.adjustANOVA 0.00208



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp2cb 7900
Prkar2b 6989
Ppp3r1 6923
Ppp3ca 6774
Prkar2a 6573
Prkacb 6521
Ppp3cb 6517
Prkar1a 6081
Ppp2r5d 6074
Ppp2ca 6007
Ppp2r1a 5784
Pde4b 5604
Calm1 5542
Ppp1r1b 5017
Ppp1ca 4208
Prkar1b 3052
Pde4c 790
Prkaca 1
Pde4a -425
Ppp2r1b -3518

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2cb 7900
Prkar2b 6989
Ppp3r1 6923
Ppp3ca 6774
Prkar2a 6573
Prkacb 6521
Ppp3cb 6517
Prkar1a 6081
Ppp2r5d 6074
Ppp2ca 6007
Ppp2r1a 5784
Pde4b 5604
Calm1 5542
Ppp1r1b 5017
Ppp1ca 4208
Prkar1b 3052
Pde4c 790
Prkaca 1
Pde4a -425
Ppp2r1b -3518
Ppp3cc -3740
Pde4d -3800
Cdk5 -4320


MITOPHAGY

MITOPHAGY
570
set MITOPHAGY
setSize 29
pANOVA 5.75e-05
s.dist 0.432
p.adjustANOVA 0.000665



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tomm20 7698
Fundc1 7515
Tomm6 6887
Atg5 6462
Rps27a 6287
Map1lc3b 5969
Vdac1 5870
Tomm22 5805
Pink1 5610
Tomm70a 5588
Sqstm1 5432
Csnk2a1 4960
Atg12 4934
Uba52 4679
Ubb 4462
Map1lc3a 4291
Mterf3 4096
Prkn 4076
Csnk2b 4024
Tomm7 2400

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tomm20 7698
Fundc1 7515
Tomm6 6887
Atg5 6462
Rps27a 6287
Map1lc3b 5969
Vdac1 5870
Tomm22 5805
Pink1 5610
Tomm70a 5588
Sqstm1 5432
Csnk2a1 4960
Atg12 4934
Uba52 4679
Ubb 4462
Map1lc3a 4291
Mterf3 4096
Prkn 4076
Csnk2b 4024
Tomm7 2400
Pgam5 2302
Tomm5 1993
Tomm40 1049
Mfn2 -565
Ubc -674
Mfn1 -1475
Csnk2a2 -2246
Ulk1 -3158
Src -5723


CRISTAE FORMATION

CRISTAE FORMATION
187
set CRISTAE FORMATION
setSize 31
pANOVA 3.33e-05
s.dist 0.431
p.adjustANOVA 0.000446



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5b 7926
Atp5a1 7859
Atp5c1 7595
Immt 7357
Atp5pb 7221
Apoo 6687
mt-Atp6 6538
mt-Atp8 6392
Chchd3 6319
Apool 6095
Atp5h 6054
Micos13 5290
Hspa9 4465
Atp5g3 4195
Atp5o 3980
Atp5j 3778
Mtx2 3332
Dmac2l 2813
Atp5d 1771
Atp5l 1715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5b 7926
Atp5a1 7859
Atp5c1 7595
Immt 7357
Atp5pb 7221
Apoo 6687
mt-Atp6 6538
mt-Atp8 6392
Chchd3 6319
Apool 6095
Atp5h 6054
Micos13 5290
Hspa9 4465
Atp5g3 4195
Atp5o 3980
Atp5j 3778
Mtx2 3332
Dmac2l 2813
Atp5d 1771
Atp5l 1715
Atp5j2 1380
Atp5e 1326
Atp5g1 1065
Micos10 1030
Tmem11 546
Atp5k 361
Chchd6 -14
Dnajc11 -1025
Mtx1 -1760
Samm50 -2183
Atp5g2 -3018


SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX

SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
1042
set SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
setSize 13
pANOVA 0.0072
s.dist 0.43
p.adjustANOVA 0.0335



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptgds 7968
Ptgr2 6513
Ptgis 6078
Ptges3 5824
Ptgs1 5375
Hpgd 4920
Hpgds 4780
Ptges 4713
Prxl2b 4285
Ptges2 1260
Tbxas1 541
Ptgs2 -3988
Cbr1 -4165

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptgds 7968
Ptgr2 6513
Ptgis 6078
Ptges3 5824
Ptgs1 5375
Hpgd 4920
Hpgds 4780
Ptges 4713
Prxl2b 4285
Ptges2 1260
Tbxas1 541
Ptgs2 -3988
Cbr1 -4165


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report