Mitch Report

date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch

	LPS	OVA
0610009B22Rik	-3.3814425	-2.2697336
0610009E02Rik	-0.3557659	-0.3519839
0610009L18Rik	-0.8507498	-0.9139963
0610010K14Rik	1.2510787	-0.1751685
0610012G03Rik	3.9729326	0.5678859
0610030E20Rik	0.1581737	1.4359134

Here are some metrics about the input data profile:

Profiling data metrics

	Profile metrics
num_genes_in_profile	16806
duplicated_genes_present	0
num_profile_genes_in_sets	8269
num_profile_genes_not_in_sets	8537
profile_pearson_correl	0.82048
profile_spearman_correl	0.81468

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene set metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	434
num_genesets_included	1170

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 281

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

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## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.LPS	s.OVA	p.LPS	p.OVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	4.73e-04	3.46e-03	0.841	-0.530	-0.6520	1.46e-03	9.11e-05
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	2.93e-04	2.24e-03	0.828	-0.517	-0.6460	1.24e-03	5.52e-05
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	1.33e-02	5.37e-02	0.718	0.527	0.4880	3.92e-03	7.49e-03
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	6.57e-03	3.11e-02	0.696	-0.455	-0.5270	6.39e-03	1.58e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.72e-02	6.53e-02	0.694	0.467	0.5140	1.06e-02	4.91e-03
APOPTOSIS INDUCED DNA FRAGMENTATION	10	2.25e-02	8.04e-02	0.678	-0.482	-0.4770	8.32e-03	9.07e-03
CD28 DEPENDENT VAV1 PATHWAY	11	1.81e-02	6.78e-02	0.656	-0.439	-0.4880	1.17e-02	5.08e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	2.17e-05	2.28e-04	0.639	-0.402	-0.4970	1.80e-04	3.58e-06
CROSSLINKING OF COLLAGEN FIBRILS	15	4.19e-03	2.14e-02	0.639	0.493	0.4060	9.37e-04	6.46e-03
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	2.31e-08	4.92e-07	0.627	-0.295	-0.5530	4.47e-03	9.60e-08
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	1.49e-02	5.85e-02	0.606	0.464	0.3890	3.74e-03	1.53e-02
PROCESSING AND ACTIVATION OF SUMO	10	2.96e-02	1.00e-01	0.598	-0.481	-0.3560	8.49e-03	5.15e-02
ACTIVATION OF SMO	16	9.13e-03	4.00e-02	0.594	0.432	0.4080	2.79e-03	4.73e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	4.01e-19	2.34e-17	0.589	-0.207	-0.5520	5.93e-03	2.23e-13
EUKARYOTIC TRANSLATION ELONGATION	87	1.08e-38	4.22e-36	0.587	-0.128	-0.5730	3.95e-02	2.39e-20
CRMPS IN SEMA3A SIGNALING	16	2.13e-03	1.26e-02	0.585	0.321	0.4890	2.63e-02	7.13e-04
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	1.51e-02	5.90e-02	0.577	0.365	0.4470	1.80e-02	3.78e-03
EUKARYOTIC TRANSLATION INITIATION	114	3.89e-40	2.27e-37	0.573	-0.168	-0.5480	2.02e-03	4.80e-24
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.58e-35	3.70e-33	0.568	-0.173	-0.5410	2.08e-03	6.32e-22
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	7.08e-02	1.92e-01	0.563	-0.383	-0.4120	3.59e-02	2.40e-02
NRAGE SIGNALS DEATH THROUGH JNK	55	1.46e-07	2.54e-06	0.559	0.348	0.4370	8.08e-06	2.04e-08
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	5.19e-33	8.68e-31	0.556	-0.151	-0.5350	1.15e-02	2.93e-19
SYNAPTIC ADHESION LIKE MOLECULES	21	3.82e-03	2.00e-02	0.554	0.362	0.4190	4.06e-03	8.85e-04
COHESIN LOADING ONTO CHROMATIN	10	4.94e-04	3.54e-03	0.554	-0.531	-0.1570	3.63e-03	3.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	2.21e-03	1.29e-02	0.552	-0.314	-0.4530	1.77e-02	6.21e-04
PROTEIN METHYLATION	17	1.36e-03	8.70e-03	0.540	-0.268	-0.4690	5.57e-02	8.09e-04
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	3.80e-02	1.25e-01	0.538	0.294	0.4500	1.07e-01	1.37e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	3.63e-03	1.93e-02	0.527	0.280	0.4470	4.55e-02	1.43e-03
COMPLEX I BIOGENESIS	56	1.50e-16	8.35e-15	0.515	-0.149	-0.4930	5.46e-02	1.69e-10
EARLY PHASE OF HIV LIFE CYCLE	13	5.21e-02	1.54e-01	0.515	-0.339	-0.3870	3.44e-02	1.56e-02
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	2.82e-10	9.17e-09	0.512	0.511	-0.0335	2.65e-04	8.11e-01
TRIGLYCERIDE CATABOLISM	14	9.20e-03	4.00e-02	0.510	-0.258	-0.4400	9.46e-02	4.38e-03
G BETA GAMMA SIGNALLING THROUGH CDC42	18	9.62e-03	4.16e-02	0.509	-0.301	-0.4110	2.70e-02	2.55e-03
SELENOAMINO ACID METABOLISM	109	3.67e-31	4.29e-29	0.500	-0.135	-0.4820	1.53e-02	3.61e-18
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.58e-02	6.12e-02	0.500	-0.345	-0.3620	7.51e-03	5.13e-03
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	6.78e-03	3.17e-02	0.498	-0.196	-0.4580	2.60e-01	8.53e-03
SIGNALING BY LEPTIN	10	3.67e-02	1.21e-01	0.498	0.247	0.4330	1.77e-01	1.78e-02
NCAM1 INTERACTIONS	40	1.24e-04	1.06e-03	0.498	0.312	0.3880	6.29e-04	2.22e-05
REPRESSION OF WNT TARGET GENES	14	4.09e-02	1.31e-01	0.495	0.390	0.3050	1.16e-02	4.79e-02
INTERLEUKIN 12 SIGNALING	37	4.64e-06	6.23e-05	0.494	-0.241	-0.4310	1.11e-02	5.70e-06
CELLULAR HEXOSE TRANSPORT	11	9.18e-02	2.31e-01	0.493	0.380	0.3130	2.89e-02	7.21e-02
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.02e-03	6.86e-03	0.489	0.283	0.3990	9.61e-03	2.60e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	2.29e-10	8.12e-09	0.488	-0.201	-0.4450	1.06e-02	1.60e-08
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.15e-09	9.44e-08	0.487	-0.198	-0.4450	1.88e-02	1.31e-07
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	1.79e-02	6.70e-02	0.486	0.321	0.3640	1.29e-02	4.83e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	3.44e-10	1.09e-08	0.482	-0.211	-0.4330	5.03e-03	8.89e-09
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	26	4.36e-03	2.21e-02	0.481	0.303	0.3740	7.54e-03	9.77e-04
RUNX3 REGULATES NOTCH SIGNALING	13	5.90e-02	1.69e-01	0.480	0.293	0.3800	6.71e-02	1.77e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	62	6.79e-06	8.63e-05	0.480	0.326	0.3520	8.95e-06	1.68e-06
INTERLEUKIN 37 SIGNALING	17	1.90e-02	7.03e-02	0.477	0.277	0.3880	4.82e-02	5.56e-03

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.LPS	s.OVA	p.LPS	p.OVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	4.73e-04	3.46e-03	0.84100	-0.530000	-0.652000	1.46e-03	9.11e-05
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	2.93e-04	2.24e-03	0.82800	-0.517000	-0.646000	1.24e-03	5.52e-05
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	1.33e-02	5.37e-02	0.71800	0.527000	0.488000	3.92e-03	7.49e-03
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	6.57e-03	3.11e-02	0.69600	-0.455000	-0.527000	6.39e-03	1.58e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.72e-02	6.53e-02	0.69400	0.467000	0.514000	1.06e-02	4.91e-03
APOPTOSIS INDUCED DNA FRAGMENTATION	10	2.25e-02	8.04e-02	0.67800	-0.482000	-0.477000	8.32e-03	9.07e-03
CD28 DEPENDENT VAV1 PATHWAY	11	1.81e-02	6.78e-02	0.65600	-0.439000	-0.488000	1.17e-02	5.08e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	2.17e-05	2.28e-04	0.63900	-0.402000	-0.497000	1.80e-04	3.58e-06
CROSSLINKING OF COLLAGEN FIBRILS	15	4.19e-03	2.14e-02	0.63900	0.493000	0.406000	9.37e-04	6.46e-03
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	2.31e-08	4.92e-07	0.62700	-0.295000	-0.553000	4.47e-03	9.60e-08
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	1.49e-02	5.85e-02	0.60600	0.464000	0.389000	3.74e-03	1.53e-02
PROCESSING AND ACTIVATION OF SUMO	10	2.96e-02	1.00e-01	0.59800	-0.481000	-0.356000	8.49e-03	5.15e-02
ACTIVATION OF SMO	16	9.13e-03	4.00e-02	0.59400	0.432000	0.408000	2.79e-03	4.73e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	4.01e-19	2.34e-17	0.58900	-0.207000	-0.552000	5.93e-03	2.23e-13
EUKARYOTIC TRANSLATION ELONGATION	87	1.08e-38	4.22e-36	0.58700	-0.128000	-0.573000	3.95e-02	2.39e-20
CRMPS IN SEMA3A SIGNALING	16	2.13e-03	1.26e-02	0.58500	0.321000	0.489000	2.63e-02	7.13e-04
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	1.51e-02	5.90e-02	0.57700	0.365000	0.447000	1.80e-02	3.78e-03
EUKARYOTIC TRANSLATION INITIATION	114	3.89e-40	2.27e-37	0.57300	-0.168000	-0.548000	2.02e-03	4.80e-24
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.58e-35	3.70e-33	0.56800	-0.173000	-0.541000	2.08e-03	6.32e-22
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	7.08e-02	1.92e-01	0.56300	-0.383000	-0.412000	3.59e-02	2.40e-02
NRAGE SIGNALS DEATH THROUGH JNK	55	1.46e-07	2.54e-06	0.55900	0.348000	0.437000	8.08e-06	2.04e-08
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	5.19e-33	8.68e-31	0.55600	-0.151000	-0.535000	1.15e-02	2.93e-19
SYNAPTIC ADHESION LIKE MOLECULES	21	3.82e-03	2.00e-02	0.55400	0.362000	0.419000	4.06e-03	8.85e-04
COHESIN LOADING ONTO CHROMATIN	10	4.94e-04	3.54e-03	0.55400	-0.531000	-0.157000	3.63e-03	3.89e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	2.21e-03	1.29e-02	0.55200	-0.314000	-0.453000	1.77e-02	6.21e-04
PROTEIN METHYLATION	17	1.36e-03	8.70e-03	0.54000	-0.268000	-0.469000	5.57e-02	8.09e-04
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	3.80e-02	1.25e-01	0.53800	0.294000	0.450000	1.07e-01	1.37e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	3.63e-03	1.93e-02	0.52700	0.280000	0.447000	4.55e-02	1.43e-03
COMPLEX I BIOGENESIS	56	1.50e-16	8.35e-15	0.51500	-0.149000	-0.493000	5.46e-02	1.69e-10
EARLY PHASE OF HIV LIFE CYCLE	13	5.21e-02	1.54e-01	0.51500	-0.339000	-0.387000	3.44e-02	1.56e-02
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	2.82e-10	9.17e-09	0.51200	0.511000	-0.033500	2.65e-04	8.11e-01
TRIGLYCERIDE CATABOLISM	14	9.20e-03	4.00e-02	0.51000	-0.258000	-0.440000	9.46e-02	4.38e-03
G BETA GAMMA SIGNALLING THROUGH CDC42	18	9.62e-03	4.16e-02	0.50900	-0.301000	-0.411000	2.70e-02	2.55e-03
SELENOAMINO ACID METABOLISM	109	3.67e-31	4.29e-29	0.50000	-0.135000	-0.482000	1.53e-02	3.61e-18
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.58e-02	6.12e-02	0.50000	-0.345000	-0.362000	7.51e-03	5.13e-03
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	6.78e-03	3.17e-02	0.49800	-0.196000	-0.458000	2.60e-01	8.53e-03
SIGNALING BY LEPTIN	10	3.67e-02	1.21e-01	0.49800	0.247000	0.433000	1.77e-01	1.78e-02
NCAM1 INTERACTIONS	40	1.24e-04	1.06e-03	0.49800	0.312000	0.388000	6.29e-04	2.22e-05
REPRESSION OF WNT TARGET GENES	14	4.09e-02	1.31e-01	0.49500	0.390000	0.305000	1.16e-02	4.79e-02
INTERLEUKIN 12 SIGNALING	37	4.64e-06	6.23e-05	0.49400	-0.241000	-0.431000	1.11e-02	5.70e-06
CELLULAR HEXOSE TRANSPORT	11	9.18e-02	2.31e-01	0.49300	0.380000	0.313000	2.89e-02	7.21e-02
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.02e-03	6.86e-03	0.48900	0.283000	0.399000	9.61e-03	2.60e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	2.29e-10	8.12e-09	0.48800	-0.201000	-0.445000	1.06e-02	1.60e-08
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	3.15e-09	9.44e-08	0.48700	-0.198000	-0.445000	1.88e-02	1.31e-07
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	1.79e-02	6.70e-02	0.48600	0.321000	0.364000	1.29e-02	4.83e-03
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	3.44e-10	1.09e-08	0.48200	-0.211000	-0.433000	5.03e-03	8.89e-09
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	26	4.36e-03	2.21e-02	0.48100	0.303000	0.374000	7.54e-03	9.77e-04
RUNX3 REGULATES NOTCH SIGNALING	13	5.90e-02	1.69e-01	0.48000	0.293000	0.380000	6.71e-02	1.77e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	62	6.79e-06	8.63e-05	0.48000	0.326000	0.352000	8.95e-06	1.68e-06
INTERLEUKIN 37 SIGNALING	17	1.90e-02	7.03e-02	0.47700	0.277000	0.388000	4.82e-02	5.56e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	1.10e-01	2.58e-01	0.47500	0.303000	0.366000	8.18e-02	3.55e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	4.64e-11	1.94e-09	0.47500	-0.191000	-0.435000	1.14e-02	7.31e-09
METABOLISM OF POLYAMINES	58	5.45e-09	1.45e-07	0.47400	-0.220000	-0.419000	3.69e-03	3.35e-08
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	7.86e-02	2.08e-01	0.47000	-0.385000	-0.269000	2.70e-02	1.22e-01
RESPIRATORY ELECTRON TRANSPORT	102	5.52e-28	5.87e-26	0.47000	-0.111000	-0.456000	5.39e-02	1.64e-15
PROCESSING OF SMDT1	16	2.07e-03	1.23e-02	0.47000	-0.192000	-0.429000	1.85e-01	2.99e-03
METHYLATION	11	6.98e-02	1.91e-01	0.46700	-0.259000	-0.389000	1.37e-01	2.55e-02
PRE NOTCH PROCESSING IN GOLGI	18	3.87e-02	1.25e-01	0.46700	0.335000	0.325000	1.37e-02	1.69e-02
GLYCOGEN SYNTHESIS	14	4.80e-03	2.39e-02	0.46700	-0.191000	-0.426000	2.17e-01	5.76e-03
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	13	6.35e-02	1.79e-01	0.46600	0.278000	0.373000	8.26e-02	1.97e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	7.20e-08	1.34e-06	0.46500	0.456000	-0.091100	4.44e-03	5.70e-01
NONSENSE MEDIATED DECAY NMD	109	9.97e-26	8.33e-24	0.46400	-0.133000	-0.444000	1.65e-02	1.11e-15
REGULATION OF EXPRESSION OF SLITS AND ROBOS	161	8.50e-35	1.66e-32	0.46300	-0.146000	-0.439000	1.42e-03	6.67e-22
INTERACTION BETWEEN L1 AND ANKYRINS	27	5.42e-04	3.82e-03	0.46000	0.229000	0.398000	3.95e-02	3.39e-04
MET ACTIVATES RAP1 AND RAC1	11	5.13e-02	1.53e-01	0.45900	-0.395000	-0.232000	2.32e-02	1.82e-01
PYRUVATE METABOLISM	27	1.15e-03	7.52e-03	0.45800	-0.242000	-0.388000	2.95e-02	4.77e-04
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	4.35e-02	1.35e-01	0.45600	-0.222000	-0.399000	2.02e-01	2.21e-02
CRISTAE FORMATION	31	4.60e-08	8.96e-07	0.45300	-0.117000	-0.438000	2.61e-01	2.42e-05
ACTIVATION OF RAC1	13	4.92e-02	1.48e-01	0.44900	-0.378000	-0.244000	1.84e-02	1.28e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	13	1.13e-01	2.63e-01	0.44800	0.305000	0.329000	5.68e-02	4.03e-02
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	7.05e-04	4.82e-03	0.44800	-0.259000	-0.366000	8.02e-03	1.79e-04
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	5.56e-11	2.24e-09	0.44800	-0.149000	-0.423000	5.84e-02	7.77e-08
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	3.83e-32	5.61e-30	0.44700	-0.098400	-0.436000	5.77e-02	3.51e-17
PROTEIN UBIQUITINATION	69	9.22e-06	1.11e-04	0.44500	-0.295000	-0.333000	2.21e-05	1.78e-06
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	8.01e-03	3.58e-02	0.44100	-0.198000	-0.395000	1.71e-01	6.28e-03
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	10	1.20e-01	2.75e-01	0.44000	0.246000	0.365000	1.78e-01	4.55e-02
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	35	1.18e-03	7.67e-03	0.44000	0.355000	0.259000	2.79e-04	7.90e-03
STABILIZATION OF P53	55	2.27e-08	4.91e-07	0.43800	-0.185000	-0.397000	1.77e-02	3.64e-07
TRANSLESION SYNTHESIS BY POLH	19	2.60e-03	1.47e-02	0.43400	-0.185000	-0.393000	1.63e-01	3.02e-03
TRANSLATION	286	3.19e-66	3.73e-63	0.43400	-0.100000	-0.422000	3.68e-03	1.20e-34
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	6.55e-02	1.83e-01	0.43300	0.261000	0.346000	8.06e-02	2.03e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	4.93e-05	4.85e-04	0.43100	-0.090900	-0.422000	5.04e-01	1.95e-03
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	5.62e-02	1.64e-01	0.42800	0.351000	0.246000	1.86e-02	9.96e-02
COLLAGEN CHAIN TRIMERIZATION	39	1.54e-03	9.73e-03	0.42700	0.267000	0.333000	3.94e-03	3.20e-04
MITOCHONDRIAL TRANSLATION	93	8.61e-27	8.39e-25	0.42400	-0.051200	-0.421000	3.94e-01	2.17e-12
RORA ACTIVATES GENE EXPRESSION	18	1.08e-03	7.13e-03	0.42400	0.145000	0.398000	2.85e-01	3.47e-03
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	53	2.48e-04	1.97e-03	0.42300	0.273000	0.323000	5.97e-04	4.70e-05
SIGNALING BY FGFR4 IN DISEASE	10	1.83e-01	3.63e-01	0.42200	-0.335000	-0.257000	6.64e-02	1.60e-01
ORC1 REMOVAL FROM CHROMATIN	68	5.10e-08	9.78e-07	0.42200	-0.203000	-0.370000	3.75e-03	1.35e-07
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.05e-01	2.52e-01	0.42100	-0.240000	-0.347000	1.51e-01	3.77e-02
TRANSLESION SYNTHESIS BY POLK	17	6.38e-03	3.05e-02	0.42100	-0.178000	-0.382000	2.05e-01	6.45e-03
CHOLESTEROL BIOSYNTHESIS	24	1.66e-03	1.03e-02	0.42000	-0.191000	-0.374000	1.05e-01	1.52e-03
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	3.95e-36	1.15e-33	0.42000	-0.104000	-0.406000	1.82e-02	3.78e-20
IRAK4 DEFICIENCY TLR2 4	12	4.37e-02	1.35e-01	0.41900	-0.193000	-0.372000	2.47e-01	2.58e-02
REGULATION OF TLR BY ENDOGENOUS LIGAND	11	1.11e-01	2.61e-01	0.41800	-0.227000	-0.351000	1.92e-01	4.40e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	1.94e-01	3.77e-01	0.41800	-0.330000	-0.256000	7.07e-02	1.61e-01
MITOTIC TELOPHASE CYTOKINESIS	13	2.01e-03	1.20e-02	0.41700	-0.405000	-0.101000	1.15e-02	5.27e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	1.75e-08	3.93e-07	0.41700	-0.184000	-0.374000	1.04e-02	1.80e-07
INTERLEUKIN 12 FAMILY SIGNALING	44	1.65e-05	1.85e-04	0.41500	-0.195000	-0.367000	2.56e-02	2.52e-05
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	2.55e-10	8.52e-09	0.41500	0.027700	-0.414000	8.07e-01	2.61e-04
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	50	5.84e-04	4.04e-03	0.41400	-0.268000	-0.315000	1.03e-03	1.18e-04
COLLAGEN FORMATION	78	1.82e-05	1.98e-04	0.41200	0.289000	0.294000	9.92e-06	7.45e-06
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	5.33e-09	1.45e-07	0.41200	-0.141000	-0.387000	7.56e-02	1.09e-06
ANTIGEN PROCESSING CROSS PRESENTATION	94	2.45e-10	8.44e-09	0.41200	-0.198000	-0.361000	9.16e-04	1.49e-09
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	1.11e-02	4.68e-02	0.41100	0.210000	0.354000	9.53e-02	5.02e-03
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	1.98e-09	6.11e-08	0.41100	-0.200000	-0.359000	1.27e-03	7.22e-09
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	64	1.62e-08	3.79e-07	0.41100	-0.174000	-0.372000	1.60e-02	2.71e-07
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	70	9.27e-08	1.65e-06	0.41000	-0.198000	-0.359000	4.15e-03	2.14e-07
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	5.49e-03	2.66e-02	0.40500	0.345000	0.212000	2.30e-03	6.13e-02
LGI ADAM INTERACTIONS	14	1.49e-01	3.14e-01	0.40500	0.290000	0.283000	6.02e-02	6.68e-02
DEGRADATION OF DVL	56	3.75e-08	7.56e-07	0.40300	-0.155000	-0.372000	4.47e-02	1.43e-06
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.23e-02	1.55e-01	0.40100	-0.250000	-0.314000	5.31e-02	1.52e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	70	1.10e-08	2.67e-07	0.40100	-0.173000	-0.362000	1.25e-02	1.67e-07
RHOBTB3 ATPASE CYCLE	10	2.04e-01	3.88e-01	0.39900	-0.235000	-0.322000	1.97e-01	7.75e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	3.04e-02	1.02e-01	0.39900	-0.215000	-0.336000	1.04e-01	1.13e-02
DEGRADATION OF AXIN	54	2.46e-07	4.17e-06	0.39700	-0.159000	-0.364000	4.34e-02	3.79e-06
PHOSPHORYLATION OF THE APC C	17	5.69e-02	1.66e-01	0.39600	-0.224000	-0.327000	1.10e-01	1.95e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	1.90e-08	4.18e-07	0.39500	-0.189000	-0.347000	3.30e-03	6.54e-08
HEDGEHOG LIGAND BIOGENESIS	62	1.21e-08	2.90e-07	0.39300	-0.149000	-0.363000	4.27e-02	7.46e-07
INTERLEUKIN 6 SIGNALING	10	7.22e-02	1.95e-01	0.39200	0.163000	0.356000	3.72e-01	5.10e-02
DEGRADATION OF GLI1 BY THE PROTEASOME	58	3.18e-07	5.02e-06	0.39100	-0.164000	-0.355000	3.06e-02	2.94e-06
CELLULAR RESPONSE TO STARVATION	145	1.53e-26	1.37e-24	0.38700	-0.094300	-0.376000	5.03e-02	5.67e-15
E2F MEDIATED REGULATION OF DNA REPLICATION	19	3.83e-02	1.25e-01	0.38700	-0.325000	-0.211000	1.41e-02	1.12e-01
MET ACTIVATES RAS SIGNALING	10	2.58e-01	4.46e-01	0.38700	-0.301000	-0.244000	9.96e-02	1.82e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	2.02e-01	3.87e-01	0.38600	0.272000	0.274000	8.96e-02	8.73e-02
G1 S DNA DAMAGE CHECKPOINTS	66	7.93e-08	1.45e-06	0.38500	-0.163000	-0.349000	2.20e-02	9.37e-07
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	1.26e-01	2.83e-01	0.38400	0.324000	0.206000	5.20e-02	2.17e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	2.09e-01	3.95e-01	0.38300	0.230000	0.306000	1.87e-01	7.86e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	5.38e-07	8.17e-06	0.38300	-0.197000	-0.328000	2.50e-03	4.68e-07
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	1.85e-01	3.66e-01	0.38200	0.294000	0.245000	6.64e-02	1.27e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	60	2.85e-04	2.19e-03	0.38200	0.235000	0.301000	1.65e-03	5.49e-05
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	1.52e-01	3.18e-01	0.38200	0.288000	0.250000	5.33e-02	9.34e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	73	1.13e-04	9.83e-04	0.38100	0.250000	0.287000	2.21e-04	2.21e-05
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	31	8.13e-06	1.01e-04	0.38000	-0.099200	-0.366000	3.39e-01	4.14e-04
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	3.31e-04	2.47e-03	0.37900	0.369000	0.089900	4.33e-03	4.86e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	9.50e-05	8.55e-04	0.37900	0.107000	0.363000	3.44e-01	1.35e-03
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	2.05e-01	3.90e-01	0.37900	-0.297000	-0.235000	7.53e-02	1.58e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	1.56e-01	3.25e-01	0.37800	-0.286000	-0.247000	5.47e-02	9.81e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	37	7.03e-03	3.26e-02	0.37700	0.230000	0.298000	1.55e-02	1.69e-03
INFLUENZA INFECTION	145	7.72e-20	5.02e-18	0.37400	-0.125000	-0.353000	9.61e-03	2.18e-13
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	2.81e-03	1.58e-02	0.37400	-0.153000	-0.341000	1.96e-01	3.80e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	1.85e-05	2.01e-04	0.37300	0.097800	0.360000	3.54e-01	6.54e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	5.34e-09	1.45e-07	0.37200	-0.014000	-0.371000	8.89e-01	2.24e-04
CDC42 GTPASE CYCLE	152	4.76e-09	1.36e-07	0.37100	0.231000	0.291000	9.50e-07	6.16e-10
PHASE 2 PLATEAU PHASE	13	2.27e-01	4.14e-01	0.37000	0.270000	0.254000	9.22e-02	1.13e-01
PENTOSE PHOSPHATE PATHWAY	13	1.26e-02	5.14e-02	0.37000	-0.107000	-0.355000	5.06e-01	2.69e-02
CELLULAR RESPONSE TO HYPOXIA	72	7.92e-09	2.01e-07	0.36900	-0.140000	-0.341000	4.02e-02	5.52e-07
BRANCHED CHAIN AMINO ACID CATABOLISM	21	8.41e-02	2.17e-01	0.36600	-0.235000	-0.280000	6.20e-02	2.62e-02
REGULATION OF BACH1 ACTIVITY	11	2.18e-01	4.06e-01	0.36600	-0.211000	-0.299000	2.25e-01	8.61e-02
DNA REPLICATION PRE INITIATION	80	3.87e-07	6.04e-06	0.36600	-0.177000	-0.320000	6.24e-03	7.38e-07
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	8.49e-09	2.11e-07	0.36600	0.160000	-0.329000	2.27e-01	1.31e-02
PYROPTOSIS	21	4.43e-02	1.37e-01	0.36500	-0.201000	-0.304000	1.11e-01	1.58e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	7.64e-03	3.47e-02	0.36400	-0.159000	-0.327000	1.86e-01	6.58e-03
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	1.26e-02	5.14e-02	0.36300	-0.197000	-0.305000	6.59e-02	4.48e-03
GAP JUNCTION ASSEMBLY	22	1.24e-10	4.68e-09	0.36200	0.293000	-0.213000	1.75e-02	8.41e-02
SYNTHESIS OF PE	13	1.66e-01	3.42e-01	0.36200	0.206000	0.297000	1.98e-01	6.36e-02
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	1.28e-01	2.87e-01	0.36200	0.234000	0.276000	8.53e-02	4.30e-02
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	4.57e-02	1.40e-01	0.36200	0.227000	0.281000	4.53e-02	1.30e-02
INTERLEUKIN 20 FAMILY SIGNALING	13	1.80e-01	3.61e-01	0.36100	0.211000	0.293000	1.87e-01	6.75e-02
PEPTIDE HORMONE METABOLISM	58	1.93e-03	1.17e-02	0.36000	-0.247000	-0.262000	1.13e-03	5.57e-04
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	5.06e-07	7.79e-06	0.35800	-0.117000	-0.339000	1.48e-01	2.85e-05
PINK1 PRKN MEDIATED MITOPHAGY	22	4.78e-04	3.47e-03	0.35800	-0.088600	-0.347000	4.72e-01	4.88e-03
NEPHRIN FAMILY INTERACTIONS	22	1.69e-02	6.41e-02	0.35800	0.168000	0.316000	1.74e-01	1.03e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	23	5.74e-02	1.66e-01	0.35800	-0.286000	-0.214000	1.75e-02	7.52e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	60	2.90e-07	4.71e-06	0.35600	-0.130000	-0.331000	8.11e-02	9.09e-06
IRE1ALPHA ACTIVATES CHAPERONES	49	4.95e-03	2.43e-02	0.35600	0.268000	0.234000	1.19e-03	4.63e-03
MITOCHONDRIAL PROTEIN IMPORT	63	8.44e-15	4.49e-13	0.35500	-0.018100	-0.355000	8.04e-01	1.14e-06
HDMS DEMETHYLATE HISTONES	27	5.65e-04	3.93e-03	0.35400	0.115000	0.334000	2.99e-01	2.65e-03
RRNA PROCESSING IN THE MITOCHONDRION	10	2.41e-02	8.48e-02	0.35300	-0.073100	-0.346000	6.89e-01	5.85e-02
AMINE LIGAND BINDING RECEPTORS	29	3.30e-03	1.80e-02	0.35300	0.156000	0.317000	1.47e-01	3.15e-03
CARNITINE METABOLISM	14	2.29e-01	4.15e-01	0.35200	0.263000	0.234000	8.85e-02	1.30e-01
PURINE CATABOLISM	16	1.49e-01	3.14e-01	0.34800	-0.207000	-0.279000	1.52e-01	5.31e-02
CHAPERONE MEDIATED AUTOPHAGY	19	3.29e-04	2.47e-03	0.34700	-0.046000	-0.344000	7.28e-01	9.42e-03
MATURATION OF NUCLEOPROTEIN	10	2.15e-02	7.80e-02	0.34700	-0.342000	-0.061700	6.14e-02	7.35e-01
RHOBTB1 GTPASE CYCLE	23	6.86e-02	1.89e-01	0.34700	-0.277000	-0.208000	2.14e-02	8.40e-02
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	3.84e-02	1.25e-01	0.34700	-0.170000	-0.302000	1.89e-01	1.93e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	1.82e-01	3.62e-01	0.34600	-0.211000	-0.274000	1.57e-01	6.57e-02
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	1.25e-01	2.83e-01	0.34600	-0.209000	-0.276000	1.25e-01	4.25e-02
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	1.22e-01	2.77e-01	0.34500	-0.213000	-0.271000	1.08e-01	4.05e-02
DNA REPLICATION	122	6.52e-09	1.70e-07	0.34500	-0.173000	-0.298000	9.72e-04	1.27e-08
NEUREXINS AND NEUROLIGINS	54	2.26e-04	1.82e-03	0.34500	0.172000	0.298000	2.85e-02	1.49e-04
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	3.85e-02	1.25e-01	0.34500	0.119000	0.324000	4.59e-01	4.34e-02
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	6.04e-03	2.90e-02	0.34400	-0.121000	-0.322000	3.37e-01	1.07e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	4.17e-02	1.32e-01	0.34300	0.230000	0.255000	2.45e-02	1.27e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	4.84e-02	1.47e-01	0.34200	0.296000	0.173000	2.21e-02	1.81e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	1.27e-02	5.14e-02	0.34200	0.184000	0.289000	7.18e-02	4.71e-03
RMTS METHYLATE HISTONE ARGININES	43	3.40e-03	1.84e-02	0.34200	0.286000	0.187000	1.16e-03	3.35e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	35	1.39e-04	1.19e-03	0.34200	0.322000	0.114000	9.73e-04	2.43e-01
INSULIN PROCESSING	24	1.56e-02	6.07e-02	0.34100	-0.303000	-0.157000	1.03e-02	1.84e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	1.66e-08	3.82e-07	0.34100	0.322000	-0.112000	7.55e-03	3.53e-01
G ALPHA 12 13 SIGNALLING EVENTS	74	4.90e-04	3.54e-03	0.34000	0.216000	0.263000	1.33e-03	9.46e-05
RHOB GTPASE CYCLE	67	1.07e-04	9.44e-04	0.34000	0.181000	0.288000	1.06e-02	4.68e-05
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	1.58e-01	3.27e-01	0.33900	-0.300000	-0.158000	8.51e-02	3.64e-01
REGULATION OF BETA CELL DEVELOPMENT	24	1.02e-01	2.46e-01	0.33900	0.234000	0.245000	4.70e-02	3.77e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	68	5.27e-13	2.46e-11	0.33900	-0.039000	-0.337000	5.78e-01	1.59e-06
S PHASE	154	5.31e-08	1.00e-06	0.33700	-0.203000	-0.269000	1.34e-05	8.47e-09
SIGNALING BY ROBO RECEPTORS	206	5.40e-23	3.72e-21	0.33600	-0.110000	-0.318000	6.69e-03	3.69e-15
P75 NTR RECEPTOR MEDIATED SIGNALLING	94	1.40e-04	1.19e-03	0.33600	0.228000	0.247000	1.35e-04	3.43e-05
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	3.92e-01	5.74e-01	0.33500	0.229000	0.244000	2.09e-01	1.81e-01
LONG TERM POTENTIATION	23	1.41e-02	5.61e-02	0.33400	0.142000	0.302000	2.39e-01	1.21e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	1.11e-02	4.69e-02	0.33400	0.063400	0.328000	6.92e-01	4.07e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS	11	1.46e-01	3.10e-01	0.33400	-0.148000	-0.299000	3.95e-01	8.59e-02
REGULATION OF RAS BY GAPS	67	3.37e-06	4.63e-05	0.33400	-0.140000	-0.303000	4.80e-02	1.81e-05
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	2.22e-01	4.09e-01	0.33300	-0.173000	-0.285000	3.20e-01	1.02e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	67	1.12e-05	1.32e-04	0.33200	-0.149000	-0.297000	3.47e-02	2.62e-05
FATTY ACYL COA BIOSYNTHESIS	32	2.89e-02	9.87e-02	0.33100	-0.193000	-0.268000	5.89e-02	8.63e-03
RRNA PROCESSING	194	5.22e-23	3.72e-21	0.33000	-0.095700	-0.316000	2.17e-02	3.23e-14
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	3.71e-01	5.54e-01	0.32900	-0.239000	-0.226000	1.69e-01	1.94e-01
CITRIC ACID CYCLE TCA CYCLE	22	3.87e-05	3.83e-04	0.32900	-0.008780	-0.329000	9.43e-01	7.55e-03
LAMININ INTERACTIONS	28	7.06e-02	1.92e-01	0.32800	0.211000	0.251000	5.31e-02	2.14e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	51	1.03e-02	4.43e-02	0.32800	0.240000	0.223000	2.99e-03	5.92e-03
SHC MEDIATED CASCADE FGFR4	11	3.80e-01	5.64e-01	0.32600	-0.233000	-0.228000	1.81e-01	1.90e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	1.59e-06	2.33e-05	0.32600	-0.149000	-0.290000	1.82e-02	4.45e-06
ANCHORING FIBRIL FORMATION	14	2.62e-01	4.49e-01	0.32400	0.253000	0.204000	1.02e-01	1.87e-01
PEXOPHAGY	11	8.25e-02	2.15e-01	0.32400	0.305000	0.109000	7.96e-02	5.32e-01
FCERI MEDIATED NF KB ACTIVATION	77	1.74e-05	1.94e-04	0.32300	-0.157000	-0.282000	1.70e-02	1.87e-05
TRP CHANNELS	18	1.42e-01	3.02e-01	0.32300	0.186000	0.264000	1.73e-01	5.22e-02
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	4.21e-01	5.99e-01	0.32300	-0.223000	-0.233000	2.23e-01	2.01e-01
INTEGRIN SIGNALING	24	8.64e-02	2.21e-01	0.32200	0.192000	0.259000	1.04e-01	2.81e-02
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	20	1.36e-01	2.97e-01	0.32200	-0.194000	-0.257000	1.32e-01	4.70e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	1.09e-01	2.58e-01	0.32100	0.231000	0.223000	4.17e-02	4.88e-02
RHOBTB2 GTPASE CYCLE	23	1.26e-01	2.83e-01	0.32100	-0.207000	-0.245000	8.59e-02	4.21e-02
INTERLEUKIN 6 FAMILY SIGNALING	19	6.90e-02	1.89e-01	0.32000	0.156000	0.280000	2.40e-01	3.46e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	3.44e-02	1.14e-01	0.32000	-0.174000	-0.268000	1.05e-01	1.25e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	5.19e-02	1.54e-01	0.31900	-0.103000	-0.302000	5.20e-01	5.95e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	7.62e-02	2.04e-01	0.31800	-0.157000	-0.277000	2.36e-01	3.68e-02
INSULIN RECEPTOR RECYCLING	20	4.19e-03	2.14e-02	0.31700	-0.078200	-0.307000	5.45e-01	1.73e-02
O LINKED GLYCOSYLATION	87	2.66e-04	2.07e-03	0.31600	0.192000	0.251000	1.97e-03	5.27e-05
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	85	2.82e-06	3.92e-05	0.31600	-0.144000	-0.281000	2.19e-02	7.43e-06
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	6.06e-02	1.73e-01	0.31500	0.121000	0.291000	4.16e-01	5.10e-02
KINESINS	48	2.01e-03	1.20e-02	0.31500	0.273000	0.158000	1.08e-03	5.79e-02
COLLAGEN DEGRADATION	51	7.65e-03	3.47e-02	0.31400	0.188000	0.251000	1.99e-02	1.92e-03
RET SIGNALING	36	2.73e-02	9.39e-02	0.31400	0.183000	0.255000	5.74e-02	8.12e-03
ECM PROTEOGLYCANS	66	4.46e-03	2.25e-02	0.31400	0.214000	0.230000	2.67e-03	1.25e-03
REGULATED NECROSIS	46	4.73e-03	2.36e-02	0.31300	-0.166000	-0.265000	5.08e-02	1.85e-03
INOSITOL PHOSPHATE METABOLISM	47	9.65e-03	4.16e-02	0.31300	0.183000	0.254000	2.96e-02	2.62e-03
RAB GERANYLGERANYLATION	59	7.86e-03	3.54e-02	0.31300	-0.210000	-0.231000	5.22e-03	2.12e-03
TIE2 SIGNALING	17	2.56e-01	4.45e-01	0.31100	-0.225000	-0.215000	1.09e-01	1.25e-01
OLFACTORY SIGNALING PATHWAY	30	9.11e-02	2.30e-01	0.30900	-0.210000	-0.227000	4.67e-02	3.15e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX	106	2.23e-04	1.81e-03	0.30900	0.209000	0.227000	1.96e-04	5.58e-05
PRE NOTCH EXPRESSION AND PROCESSING	64	4.88e-03	2.41e-02	0.30800	0.199000	0.236000	6.00e-03	1.12e-03
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	1.14e-05	1.33e-04	0.30700	0.146000	0.271000	2.01e-02	1.63e-05
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	12	3.70e-01	5.54e-01	0.30700	-0.198000	-0.235000	2.34e-01	1.59e-01
G PROTEIN ACTIVATION	22	9.28e-02	2.32e-01	0.30700	-0.166000	-0.258000	1.77e-01	3.63e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	1.69e-02	6.41e-02	0.30700	0.303000	0.047900	5.85e-02	7.65e-01
ABC TRANSPORTER DISORDERS	69	1.62e-06	2.34e-05	0.30700	-0.108000	-0.287000	1.20e-01	3.76e-05
METABOLISM OF AMINO ACIDS AND DERIVATIVES	314	1.03e-31	1.34e-29	0.30400	-0.086200	-0.292000	8.78e-03	6.17e-19
RETROGRADE NEUROTROPHIN SIGNALLING	13	6.01e-02	1.72e-01	0.30400	0.290000	0.093600	7.05e-02	5.59e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	4.70e-02	1.43e-01	0.30400	-0.215000	-0.215000	1.85e-02	1.85e-02
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	1.82e-01	3.62e-01	0.30400	0.223000	0.207000	7.01e-02	9.27e-02
BIOTIN TRANSPORT AND METABOLISM	11	3.87e-01	5.71e-01	0.30400	0.239000	0.187000	1.69e-01	2.83e-01
G2 M CHECKPOINTS	135	5.70e-07	8.55e-06	0.30400	-0.163000	-0.256000	1.05e-03	2.88e-07
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	4.29e-01	6.07e-01	0.30200	0.224000	0.203000	1.99e-01	2.43e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	3.22e-04	2.43e-03	0.30100	-0.063400	-0.294000	5.48e-01	5.28e-03
PLATELET ADHESION TO EXPOSED COLLAGEN	11	2.73e-01	4.63e-01	0.30100	-0.151000	-0.260000	3.86e-01	1.35e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	3.39e-02	1.13e-01	0.29900	0.276000	0.114000	3.24e-02	3.76e-01
MTORC1 MEDIATED SIGNALLING	24	8.13e-02	2.13e-01	0.29900	-0.160000	-0.252000	1.74e-01	3.24e-02
ENOS ACTIVATION	11	1.72e-01	3.51e-01	0.29900	-0.120000	-0.274000	4.92e-01	1.16e-01
SIGNALING BY FLT3 FUSION PROTEINS	18	2.03e-02	7.45e-02	0.29800	-0.285000	-0.086200	3.63e-02	5.27e-01
METABOLISM OF COFACTORS	18	6.26e-02	1.77e-01	0.29700	-0.122000	-0.271000	3.71e-01	4.64e-02
REGULATION OF IFNG SIGNALING	13	3.57e-01	5.45e-01	0.29700	-0.230000	-0.188000	1.51e-01	2.41e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	15	2.97e-01	4.84e-01	0.29700	0.232000	0.185000	1.19e-01	2.16e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	84	4.05e-09	1.18e-07	0.29600	-0.077300	-0.286000	2.21e-01	5.86e-06
RAS PROCESSING	24	2.37e-03	1.36e-02	0.29600	-0.066200	-0.289000	5.75e-01	1.44e-02
PKMTS METHYLATE HISTONE LYSINES	48	1.90e-04	1.56e-03	0.29600	0.105000	0.276000	2.08e-01	9.27e-04
GAP JUNCTION TRAFFICKING AND REGULATION	34	1.43e-10	5.24e-09	0.29500	0.253000	-0.151000	1.05e-02	1.27e-01
RHO GTPASES ACTIVATE IQGAPS	23	2.70e-05	2.77e-04	0.29500	0.293000	-0.032500	1.49e-02	7.87e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	2.22e-02	7.99e-02	0.29400	0.159000	0.248000	9.02e-02	8.20e-03
EFFECTS OF PIP2 HYDROLYSIS	27	8.28e-02	2.16e-01	0.29400	0.166000	0.242000	1.36e-01	2.94e-02
SUMOYLATION OF DNA METHYLATION PROTEINS	16	2.42e-01	4.28e-01	0.29200	0.168000	0.239000	2.44e-01	9.78e-02
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	2.77e-01	4.65e-01	0.29200	0.200000	0.214000	1.42e-01	1.17e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	3.09e-05	3.12e-04	0.29100	0.088000	0.277000	2.72e-01	5.42e-04
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	4.13e-02	1.31e-01	0.29000	0.272000	0.100000	4.55e-02	4.62e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	2.02e-01	3.87e-01	0.28900	0.256000	0.134000	1.10e-01	4.03e-01
DARPP 32 EVENTS	23	1.74e-01	3.53e-01	0.28900	-0.225000	-0.181000	6.15e-02	1.34e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	1.06e-01	2.54e-01	0.28700	0.270000	0.099700	9.25e-02	5.34e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	9.30e-02	2.32e-01	0.28700	0.173000	0.229000	1.00e-01	3.01e-02
IRON UPTAKE AND TRANSPORT	51	7.19e-04	4.89e-03	0.28600	-0.118000	-0.261000	1.45e-01	1.26e-03
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	85	1.07e-04	9.44e-04	0.28500	0.141000	0.247000	2.43e-02	8.06e-05
VOLTAGE GATED POTASSIUM CHANNELS	40	1.09e-02	4.63e-02	0.28400	0.136000	0.249000	1.36e-01	6.37e-03
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	3.60e-01	5.47e-01	0.28300	0.221000	0.178000	1.53e-01	2.50e-01
SIGNALING BY THE B CELL RECEPTOR BCR	104	9.50e-05	8.55e-04	0.28300	-0.156000	-0.236000	6.16e-03	3.23e-05
SEPARATION OF SISTER CHROMATIDS	165	3.90e-08	7.74e-07	0.28200	-0.141000	-0.244000	1.73e-03	6.26e-08
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	1.20e-03	7.77e-03	0.28200	-0.047600	-0.278000	6.75e-01	1.41e-02
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	37	3.62e-03	1.93e-02	0.28200	-0.107000	-0.261000	2.61e-01	6.00e-03
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	2.96e-01	4.84e-01	0.28000	0.126000	0.251000	4.91e-01	1.70e-01
DNA DAMAGE BYPASS	46	5.13e-02	1.53e-01	0.28000	-0.199000	-0.196000	1.93e-02	2.14e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	3.70e-01	5.54e-01	0.28000	0.187000	0.208000	2.11e-01	1.63e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	30	8.53e-02	2.19e-01	0.27900	-0.159000	-0.229000	1.32e-01	2.99e-02
DISEASES OF GLYCOSYLATION	126	1.07e-04	9.44e-04	0.27900	0.220000	0.171000	1.99e-05	9.37e-04
CELL CYCLE CHECKPOINTS	243	2.38e-08	4.97e-07	0.27800	-0.170000	-0.220000	5.26e-06	3.45e-09
RECYCLING PATHWAY OF L1	40	7.33e-05	7.03e-04	0.27800	0.273000	0.053700	2.83e-03	5.57e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	141	6.43e-06	8.27e-05	0.27800	-0.154000	-0.231000	1.59e-03	2.16e-06
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	50	3.15e-02	1.05e-01	0.27800	0.176000	0.215000	3.17e-02	8.54e-03
THE PHOTOTRANSDUCTION CASCADE	21	1.83e-01	3.63e-01	0.27800	-0.228000	-0.159000	7.08e-02	2.08e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	6.59e-02	1.84e-01	0.27800	0.258000	0.103000	5.82e-02	4.51e-01
EXTRACELLULAR MATRIX ORGANIZATION	240	2.81e-07	4.64e-06	0.27800	0.194000	0.198000	2.19e-07	1.32e-07
PLATELET AGGREGATION PLUG FORMATION	32	1.30e-01	2.90e-01	0.27700	0.200000	0.193000	5.05e-02	5.95e-02
RHOBTB GTPASE CYCLE	35	1.01e-01	2.46e-01	0.27700	-0.208000	-0.183000	3.35e-02	6.12e-02
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	2.97e-01	4.84e-01	0.27600	0.212000	0.177000	1.19e-01	1.95e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	2.85e-02	9.76e-02	0.27600	0.089700	0.261000	4.77e-01	3.84e-02
DEATH RECEPTOR SIGNALLING	133	8.59e-05	7.91e-04	0.27500	0.169000	0.217000	7.49e-04	1.56e-05
GP1B IX V ACTIVATION SIGNALLING	10	5.23e-01	6.83e-01	0.27500	0.182000	0.207000	3.20e-01	2.58e-01
FORMATION OF APOPTOSOME	10	3.99e-01	5.80e-01	0.27500	-0.144000	-0.234000	4.31e-01	2.00e-01
PI METABOLISM	79	1.76e-05	1.94e-04	0.27500	0.108000	0.253000	9.86e-02	1.02e-04
CALNEXIN CALRETICULIN CYCLE	26	8.55e-02	2.19e-01	0.27500	-0.141000	-0.236000	2.12e-01	3.75e-02
G2 M DNA DAMAGE CHECKPOINT	65	1.62e-02	6.24e-02	0.27400	-0.182000	-0.204000	1.12e-02	4.42e-03
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	2.69e-01	4.58e-01	0.27300	0.231000	0.146000	1.22e-01	3.28e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	2.58e-02	8.94e-02	0.27200	-0.130000	-0.239000	1.83e-01	1.43e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	2.06e-01	3.90e-01	0.27200	-0.149000	-0.227000	2.61e-01	8.63e-02
SCAVENGING BY CLASS A RECEPTORS	13	8.02e-03	3.58e-02	0.27000	0.023400	-0.269000	8.84e-01	9.29e-02
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	26	2.03e-01	3.88e-01	0.27000	0.182000	0.200000	1.09e-01	7.81e-02
GLUCONEOGENESIS	27	2.07e-06	2.91e-05	0.27000	0.255000	-0.086900	2.17e-02	4.35e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	9.84e-02	2.40e-01	0.27000	-0.137000	-0.232000	2.36e-01	4.46e-02
BUDDING AND MATURATION OF HIV VIRION	27	3.81e-04	2.82e-03	0.26900	-0.015900	-0.269000	8.86e-01	1.57e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	1.32e-05	1.53e-04	0.26900	-0.103000	-0.248000	1.04e-01	9.41e-05
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	2.99e-01	4.85e-01	0.26800	0.121000	0.239000	4.86e-01	1.70e-01
SIGNALING BY NOTCH2	33	1.41e-01	3.02e-01	0.26800	0.191000	0.188000	5.75e-02	6.15e-02
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	1.06e-01	2.56e-01	0.26800	-0.148000	-0.224000	1.75e-01	4.07e-02
RAC1 GTPASE CYCLE	176	2.56e-07	4.27e-06	0.26800	0.141000	0.228000	1.32e-03	1.86e-07
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	2.31e-01	4.19e-01	0.26700	-0.206000	-0.170000	8.71e-02	1.57e-01
ASPARTATE AND ASPARAGINE METABOLISM	10	5.55e-01	7.08e-01	0.26700	-0.185000	-0.192000	3.12e-01	2.93e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	1.33e-01	2.92e-01	0.26500	-0.177000	-0.197000	7.43e-02	4.66e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	8.31e-02	2.16e-01	0.26400	-0.235000	-0.122000	4.68e-02	3.01e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	4.00e-01	5.81e-01	0.26300	0.185000	0.187000	1.99e-01	1.96e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	1.42e-02	5.66e-02	0.26200	0.049900	0.257000	6.99e-01	4.65e-02
CELLULAR RESPONSE TO CHEMICAL STRESS	150	1.53e-12	6.88e-11	0.26100	-0.066400	-0.253000	1.61e-01	9.25e-08
CLEC7A DECTIN 1 SIGNALING	95	2.50e-04	1.98e-03	0.26100	-0.132000	-0.225000	2.59e-02	1.50e-04
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	1.43e-03	9.12e-03	0.26100	0.118000	-0.233000	4.60e-01	1.46e-01
PROTEIN LOCALIZATION	156	5.57e-14	2.71e-12	0.26100	-0.057200	-0.254000	2.18e-01	4.36e-08
KERATAN SULFATE BIOSYNTHESIS	23	8.63e-02	2.21e-01	0.26100	0.234000	0.116000	5.26e-02	3.38e-01
SIGNALLING TO RAS	18	2.39e-01	4.28e-01	0.26000	0.220000	0.139000	1.06e-01	3.06e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	2.57e-01	4.46e-01	0.25800	0.199000	0.165000	9.92e-02	1.71e-01
FC EPSILON RECEPTOR FCERI SIGNALING	124	4.43e-04	3.26e-03	0.25800	-0.158000	-0.204000	2.37e-03	8.82e-05
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	3.82e-01	5.66e-01	0.25800	-0.121000	-0.227000	5.08e-01	2.13e-01
HSF1 ACTIVATION	25	1.65e-04	1.39e-03	0.25700	0.028800	-0.256000	8.03e-01	2.69e-02
HSF1 DEPENDENT TRANSACTIVATION	33	6.03e-04	4.15e-03	0.25600	0.254000	0.036900	1.17e-02	7.14e-01
C TYPE LECTIN RECEPTORS CLRS	113	1.90e-04	1.56e-03	0.25500	-0.136000	-0.215000	1.23e-02	7.74e-05
VLDLR INTERNALISATION AND DEGRADATION	12	9.13e-02	2.30e-01	0.25500	0.250000	0.049700	1.34e-01	7.66e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	28	2.42e-04	1.94e-03	0.25400	0.005530	-0.254000	9.60e-01	2.01e-02
FRS MEDIATED FGFR4 SIGNALING	13	4.98e-01	6.62e-01	0.25400	-0.185000	-0.173000	2.48e-01	2.79e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	5.53e-01	7.06e-01	0.25400	0.172000	0.186000	3.23e-01	2.85e-01
MET ACTIVATES PTK2 SIGNALING	29	2.10e-01	3.96e-01	0.25400	0.172000	0.186000	1.08e-01	8.29e-02
INTERLEUKIN 10 SIGNALING	20	2.55e-01	4.44e-01	0.25400	-0.209000	-0.144000	1.06e-01	2.65e-01
MITOPHAGY	29	3.69e-03	1.94e-02	0.25300	-0.051200	-0.248000	6.33e-01	2.09e-02
PI 3K CASCADE FGFR4	11	3.86e-01	5.70e-01	0.25300	-0.220000	-0.124000	2.06e-01	4.77e-01
SIGNALING BY NOTCH1	75	4.73e-03	2.36e-02	0.25300	0.139000	0.211000	3.75e-02	1.58e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	13	2.42e-01	4.28e-01	0.25300	0.105000	0.230000	5.12e-01	1.52e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	32	1.76e-01	3.55e-01	0.25200	-0.189000	-0.167000	6.41e-02	1.02e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	9.80e-02	2.40e-01	0.25200	-0.103000	-0.230000	4.14e-01	6.84e-02
APOPTOTIC FACTOR MEDIATED RESPONSE	18	7.92e-02	2.08e-01	0.25100	-0.081500	-0.238000	5.49e-01	8.07e-02
RHOC GTPASE CYCLE	73	3.85e-03	2.00e-02	0.25100	0.132000	0.214000	5.12e-02	1.59e-03
ER QUALITY CONTROL COMPARTMENT ERQC	21	2.85e-01	4.73e-01	0.25100	-0.153000	-0.199000	2.25e-01	1.14e-01
SIGNALING BY BMP	24	2.55e-02	8.88e-02	0.25100	-0.240000	-0.073000	4.20e-02	5.36e-01
CHROMATIN MODIFYING ENZYMES	218	1.51e-07	2.61e-06	0.25000	0.134000	0.211000	6.35e-04	8.34e-08
TCR SIGNALING	101	1.01e-03	6.84e-03	0.25000	-0.139000	-0.208000	1.60e-02	3.16e-04
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	1.71e-01	3.48e-01	0.25000	-0.200000	-0.149000	6.19e-02	1.65e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	1.83e-03	1.12e-02	0.24900	-0.040700	0.246000	7.65e-01	7.07e-02
HOST INTERACTIONS OF HIV FACTORS	124	7.82e-05	7.44e-04	0.24900	-0.129000	-0.213000	1.29e-02	4.22e-05
SUPPRESSION OF PHAGOSOMAL MATURATION	12	9.01e-02	2.28e-01	0.24900	-0.042700	-0.245000	7.98e-01	1.41e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	2.97e-01	4.84e-01	0.24900	0.165000	0.186000	1.70e-01	1.22e-01
MITOTIC SPINDLE CHECKPOINT	96	7.53e-03	3.44e-02	0.24900	-0.178000	-0.174000	2.66e-03	3.18e-03
TRAF6 MEDIATED IRF7 ACTIVATION	15	1.07e-02	4.58e-02	0.24800	-0.015200	0.248000	9.19e-01	9.65e-02
LATE ENDOSOMAL MICROAUTOPHAGY	30	9.24e-06	1.11e-04	0.24800	0.064600	-0.239000	5.40e-01	2.32e-02
KILLING MECHANISMS	10	5.79e-01	7.24e-01	0.24800	0.158000	0.191000	3.87e-01	2.96e-01
MITOTIC METAPHASE AND ANAPHASE	206	8.91e-07	1.32e-05	0.24700	-0.136000	-0.206000	7.87e-04	3.44e-07
NETRIN 1 SIGNALING	48	1.67e-02	6.41e-02	0.24400	0.115000	0.215000	1.67e-01	9.92e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	4.80e-01	6.54e-01	0.24400	-0.141000	-0.199000	3.96e-01	2.33e-01
SIGNALING BY NOTCH3	48	9.21e-02	2.31e-01	0.24400	0.166000	0.179000	4.70e-02	3.20e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	8.00e-05	7.55e-04	0.24400	-0.067400	-0.234000	3.55e-01	1.31e-03
CHONDROITIN SULFATE BIOSYNTHESIS	19	2.22e-01	4.09e-01	0.24400	0.212000	0.121000	1.10e-01	3.63e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	2.25e-01	4.12e-01	0.24400	-0.136000	-0.202000	2.59e-01	9.34e-02
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	1.31e-01	2.91e-01	0.24400	-0.151000	-0.191000	1.13e-01	4.41e-02
O LINKED GLYCOSYLATION OF MUCINS	40	2.17e-02	7.87e-02	0.24300	0.106000	0.219000	2.48e-01	1.64e-02
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	3.84e-01	5.67e-01	0.24300	0.120000	0.212000	4.74e-01	2.04e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	120	2.54e-03	1.44e-02	0.24300	0.181000	0.162000	6.08e-04	2.26e-03
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	1.98e-01	3.83e-01	0.24300	-0.083500	-0.228000	6.02e-01	1.55e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	15	4.83e-01	6.55e-01	0.24200	0.176000	0.166000	2.39e-01	2.66e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	3.23e-01	5.09e-01	0.24100	0.189000	0.149000	1.33e-01	2.36e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	8.84e-02	2.24e-01	0.24000	-0.097800	-0.219000	4.07e-01	6.31e-02
MEIOTIC RECOMBINATION	38	8.77e-02	2.23e-01	0.24000	-0.132000	-0.200000	1.59e-01	3.29e-02
ELASTIC FIBRE FORMATION	36	7.80e-02	2.07e-01	0.23900	0.205000	0.124000	3.37e-02	1.99e-01
P75NTR SIGNALS VIA NF KB	16	9.89e-02	2.41e-01	0.23900	0.230000	0.065700	1.12e-01	6.49e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	3.39e-01	5.26e-01	0.23900	0.168000	0.170000	1.64e-01	1.58e-01
HIV TRANSCRIPTION INITIATION	45	1.21e-01	2.75e-01	0.23900	-0.168000	-0.170000	5.15e-02	4.90e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	4.70e-02	1.43e-01	0.23900	0.000635	-0.239000	9.97e-01	1.52e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	4.48e-01	6.27e-01	0.23900	-0.183000	-0.153000	2.06e-01	2.88e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	111	2.47e-05	2.55e-04	0.23800	-0.099800	-0.216000	6.94e-02	8.34e-05
CYTOPROTECTION BY HMOX1	120	3.61e-08	7.41e-07	0.23800	-0.065300	-0.229000	2.17e-01	1.54e-05
PROGRAMMED CELL DEATH	187	9.31e-08	1.65e-06	0.23700	-0.106000	-0.212000	1.26e-02	5.78e-07
AGGREPHAGY	34	4.93e-06	6.48e-05	0.23700	0.227000	-0.066300	2.18e-02	5.03e-01
STIMULI SENSING CHANNELS	74	8.94e-03	3.93e-02	0.23700	0.129000	0.199000	5.57e-02	3.15e-03
GABA RECEPTOR ACTIVATION	53	8.69e-02	2.21e-01	0.23600	-0.170000	-0.163000	3.19e-02	3.97e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT	93	6.66e-05	6.44e-04	0.23600	-0.091300	-0.218000	1.28e-01	2.89e-04
PHOSPHOLIPID METABOLISM	185	2.89e-05	2.94e-04	0.23600	0.137000	0.192000	1.34e-03	6.71e-06
DEADENYLATION OF MRNA	25	5.71e-02	1.66e-01	0.23600	-0.221000	-0.083000	5.63e-02	4.73e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	49	5.06e-02	1.52e-01	0.23600	0.196000	0.131000	1.78e-02	1.13e-01
METABOLISM OF STEROID HORMONES	20	2.10e-02	7.70e-02	0.23500	-0.030900	-0.233000	8.11e-01	7.17e-02
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	1.47e-01	3.11e-01	0.23300	-0.220000	-0.076100	1.28e-01	5.98e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	6.91e-02	1.89e-01	0.23300	0.218000	0.082000	6.50e-02	4.87e-01
INITIAL TRIGGERING OF COMPLEMENT	11	3.58e-01	5.46e-01	0.23200	0.211000	0.095000	2.25e-01	5.85e-01
DAG AND IP3 SIGNALING	40	1.25e-02	5.14e-02	0.23100	0.081300	0.216000	3.74e-01	1.82e-02
GAB1 SIGNALOSOME	13	5.66e-01	7.18e-01	0.23000	0.166000	0.160000	3.01e-01	3.19e-01
KERATAN SULFATE KERATIN METABOLISM	29	5.46e-02	1.60e-01	0.23000	0.213000	0.087700	4.75e-02	4.14e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	2.62e-01	4.49e-01	0.23000	0.149000	0.175000	1.66e-01	1.02e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	2.79e-01	4.66e-01	0.23000	0.131000	0.189000	2.75e-01	1.17e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	32	1.58e-03	9.93e-03	0.22900	0.019500	0.228000	8.49e-01	2.54e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	1.08e-01	2.58e-01	0.22900	-0.045500	-0.224000	7.68e-01	1.47e-01
PHASE II CONJUGATION OF COMPOUNDS	61	7.54e-03	3.44e-02	0.22800	-0.102000	-0.204000	1.68e-01	5.94e-03
ERBB2 ACTIVATES PTK6 SIGNALING	10	2.79e-01	4.66e-01	0.22800	0.065500	0.218000	7.20e-01	2.32e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	31	1.67e-01	3.42e-01	0.22800	0.190000	0.125000	6.74e-02	2.27e-01
CGMP EFFECTS	15	3.59e-02	1.19e-01	0.22700	-0.227000	-0.004920	1.28e-01	9.74e-01
TNFR2 NON CANONICAL NF KB PATHWAY	83	8.51e-06	1.05e-04	0.22700	-0.055300	-0.220000	3.84e-01	5.30e-04
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	2.23e-02	7.99e-02	0.22700	-0.043500	-0.222000	7.12e-01	5.93e-02
RHOA GTPASE CYCLE	141	5.28e-04	3.74e-03	0.22500	0.128000	0.185000	8.69e-03	1.45e-04
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	46	5.39e-02	1.58e-01	0.22500	0.193000	0.116000	2.34e-02	1.74e-01
APOPTOSIS	165	1.71e-06	2.43e-05	0.22500	-0.098500	-0.203000	2.92e-02	7.30e-06
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	1.89e-01	3.71e-01	0.22500	0.143000	0.174000	1.32e-01	6.79e-02
GAP JUNCTION DEGRADATION	11	2.10e-02	7.70e-02	0.22400	0.084200	-0.208000	6.29e-01	2.33e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	3.62e-01	5.47e-01	0.22400	0.131000	0.182000	3.12e-01	1.60e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	2.41e-01	4.28e-01	0.22400	-0.207000	-0.085100	1.66e-01	5.68e-01
SYNTHESIS OF PA	29	2.80e-01	4.66e-01	0.22300	0.171000	0.142000	1.10e-01	1.85e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	25	1.36e-01	2.97e-01	0.22200	-0.200000	-0.096600	8.31e-02	4.03e-01
INTRA GOLGI TRAFFIC	43	3.00e-02	1.02e-01	0.22200	0.094300	0.201000	2.85e-01	2.28e-02
SIGNALING BY FLT3 ITD AND TKD MUTANTS	15	4.19e-01	5.98e-01	0.22200	-0.188000	-0.118000	2.09e-01	4.28e-01
DSCAM INTERACTIONS	10	6.06e-01	7.48e-01	0.22100	0.129000	0.180000	4.82e-01	3.24e-01
APOPTOTIC EXECUTION PHASE	45	1.40e-01	3.01e-01	0.22100	-0.171000	-0.140000	4.72e-02	1.05e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	11	4.62e-01	6.38e-01	0.22000	-0.195000	-0.103000	2.64e-01	5.52e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	1.13e-01	2.64e-01	0.22000	0.070200	0.208000	5.87e-01	1.07e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	12	1.10e-02	4.64e-02	0.21900	0.181000	-0.124000	2.79e-01	4.58e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	2.75e-01	4.63e-01	0.21900	0.063100	0.210000	7.17e-01	2.29e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	56	1.10e-01	2.60e-01	0.21800	0.150000	0.158000	5.18e-02	4.10e-02
FRS MEDIATED FGFR2 SIGNALING	18	4.93e-01	6.60e-01	0.21700	-0.150000	-0.158000	2.72e-01	2.46e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	9.79e-02	2.40e-01	0.21700	-0.082500	-0.201000	4.67e-01	7.68e-02
PHASE 0 RAPID DEPOLARISATION	29	9.43e-02	2.34e-01	0.21700	0.088900	0.197000	4.07e-01	6.58e-02
CYTOSOLIC TRNA AMINOACYLATION	24	1.16e-02	4.81e-02	0.21600	-0.014400	-0.216000	9.03e-01	6.72e-02
FGFR2 LIGAND BINDING AND ACTIVATION	11	6.28e-01	7.60e-01	0.21600	-0.136000	-0.168000	4.35e-01	3.34e-01
GLYCOGEN STORAGE DISEASES	12	1.49e-02	5.86e-02	0.21600	0.104000	-0.189000	5.34e-01	2.56e-01
LAGGING STRAND SYNTHESIS	20	2.40e-01	4.28e-01	0.21500	-0.096700	-0.192000	4.54e-01	1.37e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	71	4.25e-02	1.33e-01	0.21500	-0.130000	-0.172000	5.91e-02	1.24e-02
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	2.59e-01	4.47e-01	0.21500	-0.062500	-0.206000	7.08e-01	2.17e-01
SIGNALING BY PDGFR IN DISEASE	20	3.86e-02	1.25e-01	0.21400	-0.212000	-0.026800	1.00e-01	8.35e-01
GLUCAGON TYPE LIGAND RECEPTORS	25	1.07e-01	2.57e-01	0.21400	-0.079400	-0.199000	4.92e-01	8.57e-02
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	5.99e-02	1.71e-01	0.21400	0.122000	0.175000	1.04e-01	2.00e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	2.14e-02	7.80e-02	0.21300	-0.110000	0.183000	5.28e-01	2.93e-01
MAPK6 MAPK4 SIGNALING	84	2.23e-03	1.29e-02	0.21300	-0.092400	-0.191000	1.44e-01	2.43e-03
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	6.28e-01	7.60e-01	0.21200	0.173000	0.122000	3.43e-01	5.04e-01
P75NTR REGULATES AXONOGENESIS	10	1.15e-01	2.68e-01	0.21200	0.010600	-0.211000	9.54e-01	2.47e-01
HDACS DEACETYLATE HISTONES	46	4.34e-02	1.35e-01	0.21100	0.188000	0.094900	2.72e-02	2.66e-01
HYALURONAN METABOLISM	15	3.30e-01	5.17e-01	0.21100	0.191000	0.089300	2.01e-01	5.49e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	25	1.19e-01	2.74e-01	0.21000	-0.079000	-0.195000	4.94e-01	9.20e-02
GLYCOGEN METABOLISM	25	4.14e-02	1.31e-01	0.21000	-0.046200	-0.205000	6.89e-01	7.66e-02
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	30	7.81e-03	3.53e-02	0.20900	0.021500	0.208000	8.39e-01	4.90e-02
REGULATED PROTEOLYSIS OF P75NTR	12	5.03e-01	6.66e-01	0.20900	0.104000	0.181000	5.32e-01	2.78e-01
PI 3K CASCADE FGFR2	16	4.94e-01	6.60e-01	0.20900	-0.169000	-0.122000	2.41e-01	3.99e-01
SHC1 EVENTS IN EGFR SIGNALING	10	5.88e-01	7.33e-01	0.20800	-0.109000	-0.178000	5.51e-01	3.31e-01
G PROTEIN BETA GAMMA SIGNALLING	30	3.13e-01	5.00e-01	0.20800	-0.133000	-0.161000	2.09e-01	1.28e-01
HIV INFECTION	220	2.41e-05	2.52e-04	0.20800	-0.114000	-0.174000	3.69e-03	8.85e-06
MRNA SPLICING	188	7.53e-06	9.47e-05	0.20800	-0.096800	-0.184000	2.23e-02	1.38e-05
ASSEMBLY OF THE HIV VIRION	16	4.15e-03	2.14e-02	0.20700	0.127000	-0.163000	3.77e-01	2.58e-01
SMOOTH MUSCLE CONTRACTION	33	2.47e-03	1.41e-02	0.20700	-0.005370	-0.206000	9.57e-01	4.01e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	5.48e-01	7.02e-01	0.20700	0.098700	0.181000	5.89e-01	3.20e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	1.97e-01	3.82e-01	0.20600	0.050900	0.200000	7.42e-01	1.95e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	2.48e-01	4.37e-01	0.20600	-0.094100	-0.183000	4.45e-01	1.38e-01
METABOLISM OF RNA	644	3.16e-19	1.94e-17	0.20500	-0.088700	-0.185000	1.32e-04	1.39e-15
GOLGI ASSOCIATED VESICLE BIOGENESIS	54	1.33e-01	2.92e-01	0.20500	-0.131000	-0.158000	9.62e-02	4.47e-02
SHC MEDIATED CASCADE FGFR1	14	6.12e-01	7.53e-01	0.20500	-0.150000	-0.139000	3.31e-01	3.66e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	107	2.45e-02	8.55e-02	0.20500	0.149000	0.140000	7.80e-03	1.22e-02
SIGNALING BY NOTCH4	83	3.20e-04	2.43e-03	0.20400	-0.062900	-0.194000	3.22e-01	2.21e-03
INTERFERON ALPHA BETA SIGNALING	52	2.81e-03	1.58e-02	0.20400	-0.198000	-0.050600	1.36e-02	5.28e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	4.10e-01	5.92e-01	0.20400	0.126000	0.161000	2.95e-01	1.82e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	77	4.21e-02	1.33e-01	0.20400	0.121000	0.164000	6.70e-02	1.26e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	40	2.42e-01	4.28e-01	0.20300	0.153000	0.134000	9.37e-02	1.43e-01
SIGNALING BY FGFR2 IN DISEASE	36	1.25e-01	2.83e-01	0.20300	-0.097700	-0.178000	3.10e-01	6.41e-02
OTHER SEMAPHORIN INTERACTIONS	19	4.48e-01	6.27e-01	0.20200	0.117000	0.165000	3.77e-01	2.13e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	31	9.89e-02	2.41e-01	0.20200	0.186000	0.079400	7.36e-02	4.44e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	2.98e-01	4.85e-01	0.20200	-0.140000	-0.145000	1.45e-01	1.33e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	2.95e-01	4.84e-01	0.20200	0.178000	0.095200	1.59e-01	4.50e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	1.84e-02	6.82e-02	0.20100	0.194000	0.055600	3.65e-02	5.48e-01
MISMATCH REPAIR	14	5.71e-01	7.20e-01	0.20100	-0.119000	-0.162000	4.41e-01	2.94e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	1.45e-05	1.65e-04	0.20100	0.036900	-0.197000	6.58e-01	1.81e-02
SIGNALING BY KIT IN DISEASE	20	2.55e-01	4.44e-01	0.20100	-0.182000	-0.083800	1.58e-01	5.17e-01
DISEASES OF METABOLISM	200	5.54e-06	7.21e-05	0.20000	0.179000	0.090700	1.37e-05	2.71e-02
TBC RABGAPS	43	2.03e-01	3.88e-01	0.20000	0.157000	0.124000	7.46e-02	1.59e-01
SIGNALING BY CSF3 G CSF	29	1.88e-01	3.70e-01	0.20000	-0.094300	-0.177000	3.80e-01	9.97e-02
ORGANIC CATION ANION ZWITTERION TRANSPORT	10	5.48e-02	1.60e-01	0.19900	0.179000	-0.086900	3.26e-01	6.34e-01
MUCOPOLYSACCHARIDOSES	11	6.52e-01	7.80e-01	0.19900	0.160000	0.119000	3.59e-01	4.96e-01
RHO GTPASES ACTIVATE KTN1	11	4.21e-01	5.99e-01	0.19900	-0.072300	-0.185000	6.78e-01	2.88e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	1.24e-02	5.13e-02	0.19800	-0.196000	0.031100	1.30e-01	8.10e-01
ONCOGENE INDUCED SENESCENCE	32	3.53e-01	5.41e-01	0.19800	0.137000	0.143000	1.80e-01	1.61e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	24	3.50e-01	5.37e-01	0.19700	-0.165000	-0.108000	1.62e-01	3.58e-01
TRIGLYCERIDE METABOLISM	23	1.39e-01	3.01e-01	0.19700	-0.064500	-0.186000	5.92e-01	1.22e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	1.82e-01	3.62e-01	0.19700	-0.160000	-0.114000	6.89e-02	1.95e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	1.77e-01	3.57e-01	0.19600	0.175000	0.087400	1.02e-01	4.15e-01
INTERFERON GAMMA SIGNALING	73	3.79e-03	1.99e-02	0.19500	-0.182000	-0.070300	7.23e-03	3.00e-01
SIGNAL AMPLIFICATION	30	2.12e-01	3.98e-01	0.19400	-0.094200	-0.170000	3.72e-01	1.08e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	4.45e-01	6.23e-01	0.19400	-0.169000	-0.095200	2.43e-01	5.10e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	2.33e-01	4.20e-01	0.19400	0.091000	0.171000	4.13e-01	1.25e-01
HS GAG DEGRADATION	21	4.58e-01	6.35e-01	0.19300	0.156000	0.114000	2.16e-01	3.65e-01
NUCLEAR IMPORT OF REV PROTEIN	32	2.97e-03	1.66e-02	0.19300	-0.011300	0.193000	9.12e-01	5.92e-02
UCH PROTEINASES	90	4.72e-06	6.27e-05	0.19300	-0.021000	-0.192000	7.31e-01	1.66e-03
INWARDLY RECTIFYING K CHANNELS	31	1.37e-01	2.99e-01	0.19300	-0.079500	-0.176000	4.43e-01	9.09e-02
TRAFFICKING OF AMPA RECEPTORS	31	3.61e-01	5.47e-01	0.19200	0.122000	0.148000	2.40e-01	1.53e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	5.66e-01	7.18e-01	0.19100	0.119000	0.149000	3.94e-01	2.86e-01
SIGNALING BY PDGF	57	6.37e-02	1.79e-01	0.19100	0.094500	0.166000	2.17e-01	3.05e-02
EXTRA NUCLEAR ESTROGEN SIGNALING	65	1.40e-01	3.02e-01	0.19100	-0.130000	-0.140000	7.10e-02	5.16e-02
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	4.25e-03	2.16e-02	0.19000	0.020500	0.189000	8.20e-01	3.60e-02
POLYMERASE SWITCHING	14	3.40e-01	5.26e-01	0.19000	-0.064200	-0.178000	6.77e-01	2.48e-01
GLUTAMATE AND GLUTAMINE METABOLISM	13	1.51e-01	3.17e-01	0.19000	0.189000	0.011000	2.37e-01	9.45e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	1.27e-02	5.14e-02	0.18900	0.188000	-0.022100	1.19e-01	8.54e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	9.47e-02	2.34e-01	0.18900	-0.127000	-0.140000	5.15e-02	3.21e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS	19	7.69e-02	2.05e-01	0.18800	-0.017000	-0.188000	8.98e-01	1.57e-01
TRANSCRIPTIONAL REGULATION BY MECP2	60	8.34e-05	7.74e-04	0.18800	0.000902	0.188000	9.90e-01	1.16e-02
INFLAMMASOMES	19	5.11e-01	6.73e-01	0.18800	-0.111000	-0.152000	4.02e-01	2.51e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	1.44e-01	3.06e-01	0.18800	0.186000	0.027200	1.97e-01	8.50e-01
SHC MEDIATED CASCADE FGFR3	13	6.83e-01	8.00e-01	0.18800	-0.130000	-0.136000	4.17e-01	3.96e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	1.65e-03	1.02e-02	0.18700	-0.012800	0.187000	8.93e-01	4.94e-02
FORMATION OF THE CORNIFIED ENVELOPE	29	2.22e-01	4.09e-01	0.18700	0.166000	0.086400	1.22e-01	4.21e-01
KERATINIZATION	29	2.22e-01	4.09e-01	0.18700	0.166000	0.086400	1.22e-01	4.21e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	1.19e-01	2.74e-01	0.18700	-0.071100	-0.173000	4.87e-01	9.06e-02
RHOH GTPASE CYCLE	37	1.99e-01	3.84e-01	0.18700	-0.096200	-0.160000	3.12e-01	9.21e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	3.20e-01	5.06e-01	0.18700	-0.061800	-0.176000	6.78e-01	2.38e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	6.69e-01	7.93e-01	0.18600	0.134000	0.130000	3.87e-01	4.01e-01
SIGNALING BY HIPPO	20	1.81e-01	3.62e-01	0.18600	-0.178000	-0.052900	1.68e-01	6.82e-01
SIGNALING BY FGFR1 IN DISEASE	32	1.46e-02	5.77e-02	0.18500	-0.185000	-0.015300	7.09e-02	8.81e-01
HEME BIOSYNTHESIS	13	6.70e-01	7.93e-01	0.18500	0.143000	0.117000	3.71e-01	4.66e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	2.44e-02	8.53e-02	0.18400	-0.071500	-0.170000	3.42e-01	2.41e-02
REGULATION OF LIPID METABOLISM BY PPARALPHA	107	3.01e-03	1.67e-02	0.18400	0.080000	0.166000	1.53e-01	3.09e-03
P75NTR RECRUITS SIGNALLING COMPLEXES	13	1.39e-01	3.01e-01	0.18400	0.184000	-0.000976	2.52e-01	9.95e-01
RND2 GTPASE CYCLE	38	2.24e-01	4.11e-01	0.18400	0.098600	0.155000	2.93e-01	9.85e-02
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	2.68e-01	4.57e-01	0.18400	-0.079300	-0.166000	5.01e-01	1.60e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	7.21e-01	8.23e-01	0.18400	0.118000	0.141000	4.98e-01	4.19e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	3.62e-01	5.47e-01	0.18300	0.173000	0.061600	2.63e-01	6.90e-01
INTERLEUKIN 15 SIGNALING	12	1.95e-01	3.78e-01	0.18300	0.009860	0.183000	9.53e-01	2.73e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	2.18e-01	4.06e-01	0.18300	-0.067000	-0.170000	5.78e-01	1.58e-01
SENSORY PROCESSING OF SOUND	60	1.93e-01	3.75e-01	0.18300	0.129000	0.129000	8.34e-02	8.42e-02
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	23	5.33e-01	6.90e-01	0.18200	-0.128000	-0.130000	2.88e-01	2.82e-01
METALLOPROTEASE DUBS	26	3.90e-01	5.72e-01	0.18200	-0.101000	-0.151000	3.72e-01	1.83e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	1.12e-02	4.69e-02	0.18200	0.001410	0.182000	9.89e-01	8.03e-02
DISEASES OF CARBOHYDRATE METABOLISM	29	2.14e-03	1.26e-02	0.18100	0.173000	-0.052300	1.06e-01	6.26e-01
ION TRANSPORT BY P TYPE ATPASES	48	2.67e-02	9.22e-02	0.18100	0.056500	0.172000	4.98e-01	3.92e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	83	4.11e-02	1.31e-01	0.18100	0.096100	0.153000	1.30e-01	1.61e-02
RHO GTPASES ACTIVATE PKNS	47	1.46e-02	5.77e-02	0.18100	-0.043300	-0.175000	6.07e-01	3.77e-02
FATTY ACID METABOLISM	145	2.94e-07	4.71e-06	0.18000	-0.031100	-0.177000	5.18e-01	2.29e-04
HATS ACETYLATE HISTONES	92	6.26e-02	1.77e-01	0.18000	0.110000	0.142000	6.76e-02	1.88e-02
METABOLISM OF FOLATE AND PTERINES	15	4.44e-01	6.23e-01	0.17900	0.163000	0.075300	2.76e-01	6.14e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	1.85e-01	3.66e-01	0.17900	0.099600	0.149000	2.33e-01	7.46e-02
ACYL CHAIN REMODELLING OF PS	14	6.89e-01	8.03e-01	0.17900	0.124000	0.130000	4.24e-01	4.01e-01
INTERLEUKIN 1 SIGNALING	96	8.08e-03	3.60e-02	0.17900	-0.078900	-0.160000	1.82e-01	6.67e-03
BETA CATENIN PHOSPHORYLATION CASCADE	16	3.66e-01	5.50e-01	0.17800	-0.166000	-0.065400	2.51e-01	6.50e-01
CARDIAC CONDUCTION	108	2.64e-02	9.14e-02	0.17800	0.101000	0.147000	6.98e-02	8.43e-03
FGFR1 MUTANT RECEPTOR ACTIVATION	25	1.14e-02	4.78e-02	0.17800	-0.175000	0.030100	1.30e-01	7.95e-01
TNF SIGNALING	43	2.33e-01	4.20e-01	0.17700	0.099500	0.147000	2.59e-01	9.64e-02
SEMAPHORIN INTERACTIONS	64	1.66e-01	3.42e-01	0.17700	0.137000	0.112000	5.82e-02	1.21e-01
ATTENUATION PHASE	23	5.72e-03	2.75e-02	0.17700	0.161000	-0.072600	1.80e-01	5.47e-01
PLASMA LIPOPROTEIN ASSEMBLY	11	6.73e-01	7.95e-01	0.17700	-0.096000	-0.149000	5.81e-01	3.93e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	6.70e-01	7.93e-01	0.17700	-0.132000	-0.117000	3.75e-01	4.31e-01
ADHERENS JUNCTIONS INTERACTIONS	29	4.58e-01	6.35e-01	0.17700	-0.134000	-0.116000	2.13e-01	2.80e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	7.32e-01	8.33e-01	0.17700	0.121000	0.129000	4.68e-01	4.40e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	16	2.77e-01	4.65e-01	0.17600	-0.046600	-0.169000	7.47e-01	2.41e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	186	6.61e-03	3.12e-02	0.17500	0.112000	0.135000	8.31e-03	1.54e-03
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	8.50e-02	2.19e-01	0.17500	0.066500	0.162000	4.56e-01	6.88e-02
HCMV EARLY EVENTS	80	1.29e-01	2.88e-01	0.17500	0.129000	0.119000	4.65e-02	6.65e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	24	1.17e-01	2.70e-01	0.17500	-0.037900	-0.171000	7.48e-01	1.47e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	1.68e-02	6.41e-02	0.17500	0.040200	-0.170000	7.44e-01	1.68e-01
DISEASES OF MITOTIC CELL CYCLE	37	2.74e-01	4.63e-01	0.17500	-0.094800	-0.147000	3.19e-01	1.22e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	1.79e-03	1.10e-02	0.17400	-0.112000	0.133000	3.21e-01	2.41e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	92	1.90e-04	1.56e-03	0.17400	-0.033200	-0.171000	5.82e-01	4.69e-03
DNA METHYLATION	20	4.57e-02	1.40e-01	0.17400	0.173000	-0.015800	1.80e-01	9.03e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	5.68e-01	7.19e-01	0.17400	-0.149000	-0.089400	3.19e-01	5.49e-01
NEUTROPHIL DEGRANULATION	383	3.14e-12	1.36e-10	0.17300	-0.052900	-0.165000	7.62e-02	3.07e-08
GLUTATHIONE SYNTHESIS AND RECYCLING	11	6.03e-01	7.46e-01	0.17300	0.155000	0.078000	3.75e-01	6.54e-01
GLYCOSAMINOGLYCAN METABOLISM	114	5.14e-02	1.53e-01	0.17300	0.132000	0.112000	1.50e-02	3.98e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	2.72e-01	4.61e-01	0.17300	0.001920	0.173000	9.92e-01	3.45e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	6.50e-03	3.09e-02	0.17200	-0.013500	0.171000	8.92e-01	8.40e-02
MICRORNA MIRNA BIOGENESIS	24	4.88e-01	6.57e-01	0.17200	0.139000	0.100000	2.37e-01	3.97e-01
RHOU GTPASE CYCLE	33	1.37e-02	5.47e-02	0.17100	0.000638	0.171000	9.95e-01	8.83e-02
PLASMA LIPOPROTEIN REMODELING	15	2.85e-02	9.76e-02	0.17100	0.127000	-0.115000	3.96e-01	4.39e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	90	3.64e-03	1.93e-02	0.17100	0.161000	0.057500	8.46e-03	3.46e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	597	4.12e-23	3.22e-21	0.17000	-0.032900	-0.167000	1.72e-01	3.81e-12
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	31	2.40e-01	4.28e-01	0.17000	0.153000	0.074500	1.41e-01	4.73e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	3.66e-01	5.50e-01	0.17000	0.127000	0.113000	1.60e-01	2.12e-01
RNA POLYMERASE III CHAIN ELONGATION	18	1.74e-01	3.53e-01	0.17000	-0.025400	-0.168000	8.52e-01	2.18e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	3.19e-01	5.05e-01	0.17000	-0.158000	-0.061900	2.22e-01	6.32e-01
RND3 GTPASE CYCLE	38	3.37e-01	5.25e-01	0.17000	0.100000	0.137000	2.86e-01	1.45e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	3.65e-01	5.50e-01	0.16900	-0.076600	-0.151000	5.25e-01	2.10e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	6.86e-01	8.02e-01	0.16900	0.098700	0.137000	5.38e-01	3.92e-01
RESOLUTION OF SISTER CHROMATID COHESION	101	8.31e-02	2.16e-01	0.16900	-0.110000	-0.128000	5.68e-02	2.61e-02
CA DEPENDENT EVENTS	36	7.85e-02	2.08e-01	0.16900	0.047500	0.162000	6.22e-01	9.33e-02
GLUTATHIONE CONJUGATION	29	4.22e-02	1.33e-01	0.16900	-0.014200	-0.168000	8.95e-01	1.18e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	5.69e-01	7.19e-01	0.16800	0.122000	0.116000	3.02e-01	3.24e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	1.08e-01	2.58e-01	0.16800	0.037500	-0.164000	8.15e-01	3.06e-01
TRANS GOLGI NETWORK VESICLE BUDDING	69	1.30e-01	2.90e-01	0.16700	-0.094600	-0.137000	1.75e-01	4.85e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	5.41e-01	6.96e-01	0.16700	-0.089700	-0.141000	4.98e-01	2.89e-01
RUNX2 REGULATES BONE DEVELOPMENT	29	4.15e-01	5.96e-01	0.16700	0.093200	0.138000	3.85e-01	1.98e-01
SODIUM CALCIUM EXCHANGERS	10	1.13e-01	2.64e-01	0.16600	-0.136000	0.095700	4.56e-01	6.00e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	6.88e-01	8.02e-01	0.16600	0.133000	0.100000	3.90e-01	5.17e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	1.09e-03	7.17e-03	0.16600	-0.094600	-0.137000	1.22e-02	3.00e-04
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	4.55e-01	6.33e-01	0.16600	-0.075700	-0.148000	5.68e-01	2.66e-01
INTERLEUKIN 7 SIGNALING	20	5.33e-01	6.90e-01	0.16500	0.089100	0.139000	4.90e-01	2.82e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	1.32e-01	2.92e-01	0.16400	0.159000	-0.041900	3.41e-01	8.01e-01
P38MAPK EVENTS	12	3.31e-01	5.19e-01	0.16400	0.162000	0.023200	3.31e-01	8.89e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	51	3.10e-01	4.99e-01	0.16300	0.123000	0.107000	1.27e-01	1.87e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	3.16e-01	5.02e-01	0.16300	0.112000	0.119000	1.62e-01	1.39e-01
L1CAM INTERACTIONS	107	7.25e-02	1.95e-01	0.16300	0.128000	0.101000	2.21e-02	7.12e-02
FCERI MEDIATED MAPK ACTIVATION	28	5.41e-01	6.96e-01	0.16300	-0.113000	-0.117000	3.00e-01	2.83e-01
INTERFERON SIGNALING	161	2.14e-05	2.28e-04	0.16300	-0.157000	-0.044700	6.16e-04	3.29e-01
CHROMOSOME MAINTENANCE	101	6.70e-03	3.15e-02	0.16300	-0.062300	-0.150000	2.79e-01	9.17e-03
RHOV GTPASE CYCLE	32	3.61e-03	1.93e-02	0.16200	-0.053200	0.153000	6.03e-01	1.34e-01
RHO GTPASES ACTIVATE ROCKS	19	4.15e-02	1.31e-01	0.16200	0.045200	-0.155000	7.33e-01	2.41e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	1.52e-01	3.18e-01	0.16200	-0.024500	0.160000	8.78e-01	3.18e-01
PURINE SALVAGE	12	6.95e-01	8.09e-01	0.16200	-0.087100	-0.136000	6.01e-01	4.14e-01
FRS MEDIATED FGFR1 SIGNALING	16	7.00e-01	8.10e-01	0.16100	-0.121000	-0.106000	4.00e-01	4.63e-01
ION CHANNEL TRANSPORT	139	2.38e-02	8.44e-02	0.16100	0.092400	0.132000	6.01e-02	7.30e-03
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	23	3.73e-01	5.57e-01	0.16000	-0.068000	-0.145000	5.73e-01	2.28e-01
CS DS DEGRADATION	14	2.09e-01	3.95e-01	0.16000	0.160000	0.001930	3.00e-01	9.90e-01
NUCLEAR ENVELOPE BREAKDOWN	49	9.18e-03	4.00e-02	0.16000	0.015200	0.159000	8.54e-01	5.45e-02
G ALPHA S SIGNALLING EVENTS	97	9.42e-02	2.34e-01	0.15900	0.127000	0.095800	3.06e-02	1.03e-01
DERMATAN SULFATE BIOSYNTHESIS	11	4.49e-01	6.27e-01	0.15900	0.155000	0.035400	3.74e-01	8.39e-01
SIGNALING BY EGFR IN CANCER	21	2.50e-01	4.40e-01	0.15800	-0.041100	-0.153000	7.44e-01	2.26e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	3.06e-02	1.03e-01	0.15800	-0.158000	-0.007660	1.11e-01	9.38e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	30	3.35e-03	1.82e-02	0.15800	0.079100	-0.137000	4.53e-01	1.94e-01
PROTEIN FOLDING	89	1.40e-05	1.61e-04	0.15800	0.012900	-0.158000	8.33e-01	1.03e-02
SHC1 EVENTS IN ERBB4 SIGNALING	12	6.34e-01	7.64e-01	0.15800	-0.141000	-0.071500	3.98e-01	6.68e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	3.36e-01	5.25e-01	0.15800	-0.017900	-0.157000	9.15e-01	3.47e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	6.30e-01	7.61e-01	0.15800	-0.137000	-0.078400	3.75e-01	6.12e-01
CONDENSATION OF PROPHASE CHROMOSOMES	27	3.61e-01	5.47e-01	0.15800	-0.071600	-0.141000	5.20e-01	2.06e-01
SULFUR AMINO ACID METABOLISM	22	1.22e-02	5.06e-02	0.15700	0.113000	-0.110000	3.59e-01	3.73e-01
REGULATION OF TNFR1 SIGNALING	34	4.93e-01	6.60e-01	0.15700	0.117000	0.105000	2.40e-01	2.88e-01
GRB2 EVENTS IN ERBB2 SIGNALING	14	5.01e-01	6.65e-01	0.15700	-0.146000	-0.056600	3.44e-01	7.14e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	3.40e-01	5.26e-01	0.15700	0.057000	0.146000	6.44e-01	2.36e-01
MEIOSIS	63	2.61e-01	4.48e-01	0.15600	-0.119000	-0.101000	1.02e-01	1.65e-01
MRNA SPLICING MINOR PATHWAY	52	1.78e-04	1.48e-03	0.15600	0.054200	-0.146000	4.99e-01	6.77e-02
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	1.38e-01	3.00e-01	0.15600	0.155000	-0.020700	2.99e-01	8.90e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	7.12e-01	8.18e-01	0.15600	0.126000	0.092200	4.15e-01	5.50e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	5.69e-03	2.75e-02	0.15600	0.150000	0.044300	1.65e-02	4.78e-01
INTEGRATION OF ENERGY METABOLISM	97	1.41e-01	3.02e-01	0.15600	0.106000	0.114000	7.06e-02	5.26e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	5.35e-01	6.91e-01	0.15600	0.067700	0.140000	6.39e-01	3.32e-01
METABOLISM OF FAT SOLUBLE VITAMINS	32	2.20e-01	4.08e-01	0.15600	0.144000	0.057600	1.57e-01	5.73e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	2.73e-01	4.63e-01	0.15500	-0.101000	-0.118000	1.70e-01	1.08e-01
CD28 CO STIMULATION	30	3.02e-01	4.87e-01	0.15500	-0.140000	-0.066000	1.83e-01	5.32e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	3.86e-01	5.70e-01	0.15500	0.152000	0.030300	3.44e-01	8.50e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	2.10e-01	3.96e-01	0.15400	0.054500	0.144000	5.94e-01	1.58e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	3.37e-01	5.25e-01	0.15400	0.153000	0.020000	3.40e-01	9.01e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	2.18e-01	4.06e-01	0.15300	0.086100	0.127000	2.49e-01	8.91e-02
JOSEPHIN DOMAIN DUBS	11	1.34e-01	2.93e-01	0.15300	0.129000	-0.083700	4.60e-01	6.31e-01
SIGNALING BY FGFR2 IIIA TM	19	1.09e-01	2.58e-01	0.15300	0.010800	-0.153000	9.35e-01	2.49e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	73	2.23e-03	1.29e-02	0.15300	-0.152000	-0.018800	2.47e-02	7.81e-01
PROLACTIN RECEPTOR SIGNALING	11	1.32e-01	2.92e-01	0.15300	-0.087500	0.126000	6.15e-01	4.71e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	8.19e-01	8.85e-01	0.15300	-0.101000	-0.115000	5.79e-01	5.30e-01
NEGATIVE REGULATION OF FLT3	15	3.94e-01	5.75e-01	0.15200	0.147000	0.038400	3.23e-01	7.97e-01
ION HOMEOSTASIS	49	3.26e-01	5.13e-01	0.15200	0.090000	0.122000	2.76e-01	1.38e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	7.49e-03	3.44e-02	0.15200	-0.043100	0.146000	6.68e-01	1.48e-01
INTEGRIN CELL SURFACE INTERACTIONS	71	1.56e-01	3.25e-01	0.15200	0.082600	0.127000	2.29e-01	6.39e-02
RHO GTPASE CYCLE	422	3.93e-06	5.34e-05	0.15200	0.075700	0.131000	7.85e-03	3.94e-06
RECEPTOR MEDIATED MITOPHAGY	11	4.88e-01	6.57e-01	0.15200	-0.034600	-0.148000	8.42e-01	3.97e-01
PI 3K CASCADE FGFR1	14	5.43e-01	6.97e-01	0.15100	-0.140000	-0.057500	3.65e-01	7.10e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	4.72e-01	6.48e-01	0.15100	0.069500	0.134000	5.72e-01	2.75e-01
PCP CE PATHWAY	91	8.18e-05	7.66e-04	0.15100	0.001730	-0.151000	9.77e-01	1.27e-02
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	3.21e-01	5.06e-01	0.15100	-0.148000	-0.028400	3.04e-01	8.44e-01
OXIDATIVE STRESS INDUCED SENESCENCE	78	1.88e-01	3.70e-01	0.15100	0.120000	0.092200	6.81e-02	1.59e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	1.36e-03	8.70e-03	0.15000	-0.089700	0.120000	3.45e-01	2.06e-01
PLASMA LIPOPROTEIN CLEARANCE	26	4.35e-02	1.35e-01	0.15000	0.149000	-0.018900	1.89e-01	8.67e-01
FANCONI ANEMIA PATHWAY	36	2.42e-01	4.28e-01	0.15000	0.137000	0.061100	1.55e-01	5.26e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	13	7.77e-01	8.61e-01	0.15000	0.113000	0.097700	4.79e-01	5.42e-01
DAP12 INTERACTIONS	29	4.16e-01	5.96e-01	0.14900	-0.130000	-0.073200	2.25e-01	4.95e-01
BIOLOGICAL OXIDATIONS	122	9.43e-05	8.55e-04	0.14900	-0.021400	-0.148000	6.84e-01	4.84e-03
PEROXISOMAL LIPID METABOLISM	26	6.04e-01	7.47e-01	0.14900	-0.114000	-0.096600	3.16e-01	3.94e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	6.11e-02	1.74e-01	0.14800	-0.137000	0.057500	3.15e-01	6.73e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	26	9.40e-02	2.34e-01	0.14800	-0.006150	-0.148000	9.57e-01	1.92e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	1.91e-01	3.73e-01	0.14800	0.036700	0.143000	7.37e-01	1.90e-01
G PROTEIN MEDIATED EVENTS	52	4.91e-02	1.48e-01	0.14700	0.037000	0.142000	6.44e-01	7.60e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	3.91e-01	5.72e-01	0.14700	-0.010200	-0.147000	9.53e-01	4.00e-01
M PHASE	339	1.08e-03	7.13e-03	0.14700	-0.089100	-0.117000	4.90e-03	2.31e-04
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	1.12e-01	2.62e-01	0.14700	-0.004030	-0.146000	9.73e-01	2.14e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	6.38e-02	1.79e-01	0.14600	-0.093200	0.113000	5.19e-01	4.34e-01
RHO GTPASES ACTIVATE PAKS	21	2.82e-01	4.69e-01	0.14600	-0.033300	-0.142000	7.92e-01	2.60e-01
LDL CLEARANCE	16	7.07e-02	1.92e-01	0.14600	0.080900	-0.121000	5.75e-01	4.02e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	1.30e-01	2.90e-01	0.14500	0.024700	-0.143000	8.60e-01	3.06e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	1.22e-01	2.77e-01	0.14500	-0.055000	-0.135000	4.93e-01	9.32e-02
SIGNALING BY WNT IN CANCER	30	1.65e-01	3.41e-01	0.14500	0.033100	0.141000	7.54e-01	1.80e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	18	6.66e-01	7.90e-01	0.14500	-0.120000	-0.081900	3.79e-01	5.47e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	6.71e-01	7.93e-01	0.14500	-0.117000	-0.085600	3.76e-01	5.18e-01
ERK MAPK TARGETS	22	5.73e-01	7.20e-01	0.14400	0.075800	0.123000	5.38e-01	3.18e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	4.11e-01	5.92e-01	0.14400	-0.003790	-0.144000	9.83e-01	4.29e-01
REDUCTION OF CYTOSOLIC CA LEVELS	12	2.89e-01	4.78e-01	0.14400	-0.144000	0.009990	3.88e-01	9.52e-01
CD28 DEPENDENT PI3K AKT SIGNALING	20	2.47e-01	4.36e-01	0.14400	0.021900	0.143000	8.65e-01	2.70e-01
PERK REGULATES GENE EXPRESSION	28	6.19e-01	7.59e-01	0.14400	-0.103000	-0.100000	3.44e-01	3.59e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	4.21e-01	5.99e-01	0.14400	-0.088700	-0.113000	3.04e-01	1.89e-01
FRS MEDIATED FGFR3 SIGNALING	15	7.75e-01	8.60e-01	0.14400	-0.102000	-0.101000	4.93e-01	4.99e-01
LYSOSOME VESICLE BIOGENESIS	32	9.74e-02	2.39e-01	0.14300	-0.017600	-0.142000	8.64e-01	1.65e-01
COSTIMULATION BY THE CD28 FAMILY	49	2.36e-01	4.24e-01	0.14200	-0.126000	-0.066400	1.28e-01	4.21e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	139	1.53e-02	5.98e-02	0.14200	0.126000	0.065200	1.02e-02	1.85e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	1.81e-01	3.62e-01	0.14100	-0.119000	0.076300	4.94e-01	6.61e-01
GLUCOSE METABOLISM	80	9.70e-02	2.39e-01	0.14100	0.125000	0.065800	5.31e-02	3.09e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	2.90e-01	4.78e-01	0.14100	-0.035100	0.137000	8.48e-01	4.54e-01
UNFOLDED PROTEIN RESPONSE UPR	85	2.36e-01	4.24e-01	0.14100	0.106000	0.093000	9.13e-02	1.38e-01
REPRODUCTION	75	2.89e-01	4.78e-01	0.14100	-0.103000	-0.095700	1.22e-01	1.52e-01
PYRIMIDINE SALVAGE	10	4.45e-01	6.23e-01	0.14100	0.141000	0.007140	4.41e-01	9.69e-01
MAP2K AND MAPK ACTIVATION	36	5.23e-01	6.83e-01	0.14000	0.110000	0.086600	2.56e-01	3.69e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	3.81e-01	5.65e-01	0.14000	0.006330	0.139000	9.70e-01	4.03e-01
RNA POLYMERASE I PROMOTER ESCAPE	47	5.89e-02	1.69e-01	0.14000	-0.026600	-0.137000	7.53e-01	1.04e-01
COMPLEMENT CASCADE	24	3.13e-01	5.00e-01	0.13900	-0.039200	-0.134000	7.40e-01	2.57e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	6.18e-01	7.58e-01	0.13900	0.095800	0.101000	3.64e-01	3.39e-01
PEROXISOMAL PROTEIN IMPORT	57	2.22e-01	4.09e-01	0.13900	-0.067700	-0.121000	3.77e-01	1.13e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	23	6.78e-01	7.97e-01	0.13900	-0.106000	-0.089600	3.78e-01	4.57e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	5.35e-02	1.58e-01	0.13900	0.032100	0.135000	6.84e-01	8.63e-02
PROLONGED ERK ACTIVATION EVENTS	13	5.24e-01	6.83e-01	0.13800	-0.133000	-0.036500	4.06e-01	8.20e-01
TP53 REGULATES METABOLIC GENES	85	5.78e-02	1.67e-01	0.13800	-0.056000	-0.126000	3.73e-01	4.43e-02
ONCOGENIC MAPK SIGNALING	77	2.59e-01	4.46e-01	0.13800	0.085300	0.108000	1.96e-01	1.00e-01
HIV ELONGATION ARREST AND RECOVERY	32	1.07e-01	2.56e-01	0.13800	0.137000	0.014900	1.80e-01	8.84e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA	13	8.13e-01	8.80e-01	0.13800	0.093200	0.101000	5.61e-01	5.26e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	4.93e-01	6.60e-01	0.13700	-0.070800	-0.118000	5.02e-01	2.64e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	343	5.15e-03	2.52e-02	0.13700	-0.092600	-0.101000	3.28e-03	1.41e-03
PROCESSING OF INTRONLESS PRE MRNAS	19	4.27e-01	6.06e-01	0.13700	-0.130000	-0.040500	3.25e-01	7.60e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	57	3.50e-03	1.89e-02	0.13700	-0.016600	0.136000	8.29e-01	7.67e-02
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	7.97e-01	8.70e-01	0.13600	0.075200	0.113000	6.66e-01	5.15e-01
NUCLEOBASE CATABOLISM	31	5.73e-01	7.20e-01	0.13600	-0.081600	-0.109000	4.32e-01	2.94e-01
NOD1 2 SIGNALING PATHWAY	34	2.01e-01	3.87e-01	0.13600	0.036900	0.131000	7.10e-01	1.87e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	3.40e-01	5.26e-01	0.13600	-0.136000	0.001210	3.98e-01	9.94e-01
MITOTIC G2 G2 M PHASES	186	1.77e-03	1.09e-02	0.13500	-0.051400	-0.125000	2.27e-01	3.44e-03
SARS COV 1 INFECTION	48	4.51e-02	1.39e-01	0.13500	-0.016600	-0.134000	8.42e-01	1.09e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	5.18e-01	6.78e-01	0.13400	-0.121000	-0.057000	3.24e-01	6.44e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	10	7.87e-01	8.66e-01	0.13400	0.116000	0.066300	5.24e-01	7.17e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	168	1.92e-02	7.09e-02	0.13400	0.116000	0.066600	9.46e-03	1.37e-01
CELL CYCLE MITOTIC	474	5.56e-04	3.89e-03	0.13300	-0.083400	-0.104000	1.93e-03	1.09e-04
THE NLRP3 INFLAMMASOME	15	6.17e-01	7.58e-01	0.13300	-0.052900	-0.122000	7.23e-01	4.12e-01
INFECTIOUS DISEASE	721	9.83e-15	5.00e-13	0.13300	-0.034900	-0.129000	1.13e-01	4.72e-09
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	1.25e-01	2.82e-01	0.13300	0.118000	-0.060300	4.13e-01	6.76e-01
VIRAL MESSENGER RNA SYNTHESIS	42	2.96e-01	4.84e-01	0.13300	0.056600	0.120000	5.26e-01	1.79e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.21e-01	6.81e-01	0.13200	0.025000	0.130000	8.81e-01	4.36e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	2.33e-01	4.20e-01	0.13200	0.004680	0.132000	9.71e-01	3.08e-01
METABOLISM OF NUCLEOTIDES	92	6.65e-02	1.85e-01	0.13100	-0.054600	-0.120000	3.66e-01	4.76e-02
CELL CYCLE	591	2.56e-04	2.01e-03	0.13100	-0.087900	-0.097200	2.78e-04	5.84e-05
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	66	3.48e-01	5.36e-01	0.13100	0.103000	0.080400	1.47e-01	2.59e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	44	3.37e-01	5.25e-01	0.13100	-0.115000	-0.061400	1.85e-01	4.81e-01
CA2 PATHWAY	56	3.43e-02	1.14e-01	0.13100	-0.130000	-0.016700	9.36e-02	8.29e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	3.13e-01	5.00e-01	0.13100	-0.038000	-0.125000	7.28e-01	2.52e-01
SIGNALING BY ERBB4	56	2.87e-01	4.76e-01	0.13100	-0.113000	-0.065300	1.44e-01	3.98e-01
MET PROMOTES CELL MOTILITY	39	4.43e-01	6.23e-01	0.13000	0.067800	0.111000	4.64e-01	2.29e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	1.27e-02	5.14e-02	0.13000	-0.058200	0.117000	5.52e-01	2.33e-01
SPRY REGULATION OF FGF SIGNALING	16	3.90e-01	5.72e-01	0.13000	0.129000	0.017700	3.72e-01	9.03e-01
METABOLISM OF PORPHYRINS	19	3.94e-01	5.75e-01	0.13000	0.127000	0.028200	3.40e-01	8.32e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	5.52e-01	7.05e-01	0.12900	-0.120000	-0.047400	3.77e-01	7.28e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE	35	1.83e-02	6.82e-02	0.12900	0.045900	-0.121000	6.38e-01	2.17e-01
DNA STRAND ELONGATION	32	4.10e-01	5.92e-01	0.12900	-0.054400	-0.117000	5.94e-01	2.53e-01
CIRCADIAN CLOCK	68	2.20e-02	7.94e-02	0.12900	0.019200	0.127000	7.85e-01	6.92e-02
TRANSCRIPTION OF THE HIV GENOME	67	3.97e-01	5.79e-01	0.12900	-0.094300	-0.087400	1.82e-01	2.16e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	44	2.01e-01	3.87e-01	0.12800	0.121000	0.042100	1.64e-01	6.29e-01
PI 3K CASCADE FGFR3	13	6.59e-01	7.86e-01	0.12800	-0.119000	-0.047900	4.57e-01	7.65e-01
SIGNALING BY ERYTHROPOIETIN	24	6.26e-01	7.60e-01	0.12800	0.068200	0.109000	5.63e-01	3.57e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	10	4.84e-01	6.55e-01	0.12800	0.000738	0.128000	9.97e-01	4.83e-01
ERKS ARE INACTIVATED	13	7.82e-01	8.64e-01	0.12800	0.108000	0.069200	5.02e-01	6.66e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	21	7.23e-02	1.95e-01	0.12700	0.067800	-0.108000	5.91e-01	3.93e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	3.12e-01	5.00e-01	0.12700	-0.113000	-0.058700	1.73e-01	4.77e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	2.40e-01	4.28e-01	0.12700	-0.093100	0.086000	5.93e-01	6.22e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	143	3.76e-02	1.24e-01	0.12600	-0.059400	-0.112000	2.21e-01	2.13e-02
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	6.47e-01	7.76e-01	0.12600	-0.088000	-0.090600	3.82e-01	3.68e-01
SELECTIVE AUTOPHAGY	71	1.11e-04	9.72e-04	0.12600	0.091300	-0.087000	1.83e-01	2.05e-01
ZINC TRANSPORTERS	16	8.10e-01	8.78e-01	0.12600	-0.092200	-0.085400	5.23e-01	5.54e-01
KERATAN SULFATE DEGRADATION	11	2.55e-01	4.44e-01	0.12600	0.072700	-0.102000	6.76e-01	5.57e-01
PLATELET CALCIUM HOMEOSTASIS	27	5.93e-01	7.37e-01	0.12500	0.065100	0.107000	5.58e-01	3.36e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	27	2.66e-01	4.54e-01	0.12500	-0.023300	-0.123000	8.34e-01	2.68e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	139	1.58e-02	6.12e-02	0.12500	-0.046900	-0.116000	3.40e-01	1.86e-02
SIGNALING BY NTRK3 TRKC	17	7.72e-01	8.60e-01	0.12500	0.074400	0.100000	5.95e-01	4.75e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	3.46e-01	5.33e-01	0.12500	0.092900	0.083000	1.49e-01	1.97e-01
MHC CLASS II ANTIGEN PRESENTATION	102	1.11e-05	1.32e-04	0.12400	0.053600	-0.112000	3.50e-01	5.06e-02
NEDDYLATION	218	1.02e-02	4.37e-02	0.12400	-0.060100	-0.109000	1.27e-01	5.75e-03
NEURONAL SYSTEM	366	2.32e-03	1.34e-02	0.12400	0.068500	0.103000	2.48e-02	7.42e-04
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	1.02e-01	2.46e-01	0.12400	0.000884	0.124000	9.93e-01	2.12e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	7.02e-01	8.10e-01	0.12300	-0.105000	-0.063800	4.28e-01	6.30e-01
G0 AND EARLY G1	25	6.63e-01	7.87e-01	0.12300	-0.102000	-0.068500	3.78e-01	5.54e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	7.79e-01	8.63e-01	0.12300	0.056100	0.109000	7.47e-01	5.31e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	1.27e-02	5.14e-02	0.12200	-0.036400	0.116000	6.73e-01	1.77e-01
DAP12 SIGNALING	24	7.42e-01	8.43e-01	0.12200	-0.082300	-0.089600	4.85e-01	4.47e-01
PI3K AKT SIGNALING IN CANCER	87	1.50e-01	3.14e-01	0.12200	0.056100	0.108000	3.66e-01	8.22e-02
SIGNALING BY GPCR	458	3.27e-03	1.80e-02	0.12100	0.078400	0.092400	4.16e-03	7.33e-04
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	32	1.42e-01	3.02e-01	0.12100	0.121000	0.004740	2.37e-01	9.63e-01
SIGNALING BY EGFR	46	5.04e-01	6.67e-01	0.12000	0.069600	0.098200	4.14e-01	2.49e-01
AQUAPORIN MEDIATED TRANSPORT	40	3.14e-01	5.00e-01	0.12000	-0.042800	-0.112000	6.39e-01	2.22e-01
METABOLISM OF CARBOHYDRATES	257	2.68e-04	2.08e-03	0.11900	0.113000	0.037800	1.81e-03	2.98e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	2.09e-01	3.95e-01	0.11900	-0.111000	-0.043300	1.54e-01	5.79e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	4.69e-01	6.45e-01	0.11900	-0.083500	-0.084700	2.45e-01	2.38e-01
CELL CELL COMMUNICATION	106	2.51e-01	4.40e-01	0.11900	0.073100	0.093500	1.94e-01	9.67e-02
RA BIOSYNTHESIS PATHWAY	14	5.26e-01	6.83e-01	0.11800	-0.019300	-0.117000	9.01e-01	4.50e-01
INNATE IMMUNE SYSTEM	770	8.85e-11	3.45e-09	0.11800	-0.037800	-0.112000	7.62e-02	1.49e-07
ARACHIDONIC ACID METABOLISM	39	2.95e-02	1.00e-01	0.11800	0.034600	-0.113000	7.09e-01	2.23e-01
ANTIMICROBIAL PEPTIDES	12	2.74e-01	4.63e-01	0.11800	0.063100	-0.099700	7.05e-01	5.50e-01
SIGNALING BY ERBB2 IN CANCER	24	3.89e-01	5.72e-01	0.11800	-0.115000	-0.027200	3.31e-01	8.18e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	8.23e-03	3.65e-02	0.11800	0.096600	-0.067600	2.68e-01	4.38e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	63	1.08e-03	7.13e-03	0.11700	0.091900	-0.072000	2.07e-01	3.23e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	62	3.00e-01	4.87e-01	0.11600	-0.102000	-0.054500	1.63e-01	4.58e-01
GENERATION OF SECOND MESSENGER MOLECULES	19	7.93e-01	8.69e-01	0.11500	-0.070900	-0.090200	5.93e-01	4.96e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	4.85e-03	2.40e-02	0.11400	-0.113000	0.018200	9.53e-02	7.88e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	2.62e-01	4.49e-01	0.11400	-0.015000	0.113000	9.10e-01	3.93e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	61	4.97e-01	6.62e-01	0.11400	0.072900	0.087500	3.25e-01	2.37e-01
HIV LIFE CYCLE	142	2.19e-01	4.07e-01	0.11400	-0.077800	-0.082900	1.10e-01	8.84e-02
CTLA4 INHIBITORY SIGNALING	20	6.78e-01	7.97e-01	0.11300	-0.051400	-0.101000	6.90e-01	4.35e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	4.22e-01	5.99e-01	0.11300	0.048200	0.102000	5.93e-01	2.58e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	3.16e-01	5.02e-01	0.11300	0.054600	-0.098800	7.43e-01	5.53e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	8.80e-01	9.22e-01	0.11300	0.082900	0.076400	6.19e-01	6.47e-01
DISEASES OF DNA REPAIR	11	6.12e-01	7.53e-01	0.11200	-0.111000	-0.014000	5.24e-01	9.36e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	22	1.09e-01	2.58e-01	0.11200	0.081100	-0.076800	5.10e-01	5.33e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	8.37e-01	8.96e-01	0.11100	0.082500	0.074900	5.56e-01	5.93e-01
SIGNALING BY RETINOIC ACID	34	4.97e-01	6.62e-01	0.11100	-0.047100	-0.101000	6.35e-01	3.10e-01
INTERLEUKIN 1 FAMILY SIGNALING	122	9.07e-02	2.29e-01	0.11100	-0.048400	-0.099900	3.56e-01	5.69e-02
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	101	2.75e-01	4.63e-01	0.11100	0.090900	0.063700	1.15e-01	2.69e-01
HEDGEHOG ON STATE	83	7.46e-03	3.44e-02	0.11100	0.005550	-0.111000	9.30e-01	8.13e-02
CD209 DC SIGN SIGNALING	18	8.33e-01	8.94e-01	0.11100	-0.078400	-0.078400	5.65e-01	5.65e-01
HEME SIGNALING	44	2.40e-02	8.47e-02	0.11100	-0.040300	0.103000	6.44e-01	2.36e-01
RHO GTPASES ACTIVATE CIT	18	1.69e-01	3.46e-01	0.11100	0.081600	-0.074700	5.49e-01	5.83e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	7.76e-01	8.60e-01	0.11100	-0.051100	-0.098100	7.41e-01	5.25e-01
PREGNENOLONE BIOSYNTHESIS	12	3.24e-01	5.09e-01	0.11000	0.094000	-0.058100	5.73e-01	7.27e-01
MYOGENESIS	25	2.66e-01	4.54e-01	0.11000	0.001480	0.110000	9.90e-01	3.40e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	8.87e-01	9.28e-01	0.11000	0.078300	0.076900	6.39e-01	6.45e-01
INTERLEUKIN 27 SIGNALING	10	8.17e-01	8.83e-01	0.11000	0.046300	0.099500	8.00e-01	5.86e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	6.99e-01	8.10e-01	0.11000	0.082200	0.072600	4.00e-01	4.58e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	15	7.11e-01	8.18e-01	0.10900	0.101000	0.041100	4.99e-01	7.83e-01
HCMV INFECTION	103	6.79e-02	1.88e-01	0.10900	0.103000	0.035600	7.14e-02	5.33e-01
REGULATION OF IFNA SIGNALING	12	8.50e-01	9.05e-01	0.10900	0.059000	0.091300	7.23e-01	5.84e-01
SARS COV 2 INFECTION	65	7.45e-02	2.00e-01	0.10800	-0.015800	-0.107000	8.26e-01	1.35e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	7.50e-01	8.47e-01	0.10800	-0.103000	-0.030700	5.71e-01	8.67e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	7.53e-01	8.49e-01	0.10800	0.044200	0.098300	7.75e-01	5.24e-01
ERBB2 REGULATES CELL MOTILITY	13	3.13e-01	5.00e-01	0.10800	-0.056300	0.091900	7.25e-01	5.66e-01
STRIATED MUSCLE CONTRACTION	28	1.41e-01	3.02e-01	0.10700	0.024700	-0.104000	8.21e-01	3.39e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	12	4.19e-01	5.98e-01	0.10700	0.028200	-0.104000	8.66e-01	5.35e-01
EPHRIN SIGNALING	19	6.21e-01	7.59e-01	0.10700	0.101000	0.035100	4.47e-01	7.91e-01
HS GAG BIOSYNTHESIS	29	1.93e-01	3.75e-01	0.10700	-0.008000	0.106000	9.41e-01	3.22e-01
SIGNALING BY INSULIN RECEPTOR	61	3.91e-01	5.72e-01	0.10700	-0.052100	-0.093000	4.82e-01	2.09e-01
PECAM1 INTERACTIONS	12	8.88e-01	9.28e-01	0.10700	0.080900	0.069300	6.28e-01	6.78e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	7.71e-01	8.60e-01	0.10600	-0.047800	-0.094800	7.48e-01	5.25e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	542	6.80e-03	3.17e-02	0.10600	-0.078700	-0.071100	1.79e-03	4.77e-03
RHO GTPASES ACTIVATE NADPH OXIDASES	18	4.67e-01	6.43e-01	0.10600	0.106000	0.010100	4.38e-01	9.41e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	87	4.35e-01	6.14e-01	0.10600	-0.079700	-0.069800	1.99e-01	2.61e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	21	1.80e-01	3.61e-01	0.10600	0.046500	-0.094900	7.13e-01	4.51e-01
NICOTINATE METABOLISM	24	5.42e-01	6.96e-01	0.10500	0.032600	0.099800	7.82e-01	3.97e-01
SIGNALING BY PTK6	50	4.94e-01	6.60e-01	0.10500	0.090300	0.052800	2.69e-01	5.18e-01
PYRIMIDINE CATABOLISM	10	6.06e-01	7.48e-01	0.10400	0.001950	-0.104000	9.91e-01	5.67e-01
LYSINE CATABOLISM	10	7.59e-01	8.53e-01	0.10400	0.099900	0.028300	5.84e-01	8.77e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	37	4.96e-01	6.62e-01	0.10400	-0.041900	-0.094700	6.59e-01	3.19e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	3.39e-01	5.26e-01	0.10400	-0.054100	-0.088300	3.95e-01	1.65e-01
UB SPECIFIC PROCESSING PROTEASES	169	2.11e-01	3.96e-01	0.10300	-0.066800	-0.078600	1.34e-01	7.83e-02
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	2.29e-02	8.16e-02	0.10300	0.093100	-0.044300	2.60e-01	5.92e-01
SIGNALING BY NTRKS	129	2.26e-01	4.13e-01	0.10300	0.085300	0.056900	9.47e-02	2.65e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	5.50e-01	7.04e-01	0.10200	0.095600	0.036300	3.81e-01	7.39e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	25	6.78e-01	7.97e-01	0.10200	-0.047000	-0.090800	6.84e-01	4.32e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	622	3.05e-03	1.68e-02	0.10200	0.062800	0.080200	7.73e-03	6.76e-04
MUSCLE CONTRACTION	163	1.90e-01	3.73e-01	0.10200	0.082000	0.060100	7.12e-02	1.86e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	7.74e-01	8.60e-01	0.10200	-0.078100	-0.065000	4.75e-01	5.52e-01
DUAL INCISION IN TC NER	64	3.68e-01	5.52e-01	0.10100	-0.045700	-0.090300	5.27e-01	2.12e-01
SIGNALING BY INTERLEUKINS	346	5.37e-03	2.62e-02	0.10100	-0.046300	-0.090000	1.40e-01	4.10e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	8.72e-01	9.20e-01	0.10100	-0.055800	-0.084400	7.38e-01	6.13e-01
N GLYCAN ANTENNAE ELONGATION	15	8.73e-01	9.20e-01	0.10100	0.064500	0.077600	6.65e-01	6.03e-01
FCERI MEDIATED CA 2 MOBILIZATION	26	3.76e-01	5.59e-01	0.10100	-0.100000	-0.010400	3.77e-01	9.27e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	17	8.29e-01	8.91e-01	0.10000	-0.083300	-0.056000	5.52e-01	6.89e-01
FOXO MEDIATED TRANSCRIPTION	57	5.61e-01	7.14e-01	0.10000	-0.058600	-0.081400	4.44e-01	2.88e-01
NONHOMOLOGOUS END JOINING NHEJ	43	6.94e-01	8.08e-01	0.10000	-0.074800	-0.066300	3.96e-01	4.52e-01
NEGATIVE REGULATION OF MAPK PATHWAY	42	1.20e-01	2.75e-01	0.09990	0.099600	-0.008300	2.64e-01	9.26e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	58	1.75e-02	6.61e-02	0.09960	0.038500	-0.091900	6.12e-01	2.26e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	2.92e-01	4.81e-01	0.09920	0.025500	-0.095800	8.43e-01	4.58e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	6.99e-01	8.10e-01	0.09910	-0.053000	-0.083700	6.10e-01	4.20e-01
REGULATION OF PTEN GENE TRANSCRIPTION	58	6.21e-01	7.59e-01	0.09910	0.072900	0.067100	3.37e-01	3.77e-01
AUTOPHAGY	137	2.15e-05	2.28e-04	0.09900	0.065100	-0.074600	1.89e-01	1.32e-01
EGFR DOWNREGULATION	27	7.90e-01	8.67e-01	0.09860	0.062300	0.076400	5.75e-01	4.92e-01
SIGNALING BY FGFR1	42	6.44e-01	7.74e-01	0.09860	-0.055400	-0.081500	5.34e-01	3.61e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	4.58e-01	6.35e-01	0.09850	0.078200	0.060000	2.13e-01	3.40e-01
RND1 GTPASE CYCLE	37	1.16e-01	2.69e-01	0.09840	-0.021900	0.095900	8.18e-01	3.13e-01
DNA DAMAGE RECOGNITION IN GG NER	38	7.66e-02	2.04e-01	0.09840	0.091100	-0.037200	3.31e-01	6.92e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	9.23e-01	9.50e-01	0.09810	-0.068000	-0.070600	7.10e-01	6.99e-01
PEPTIDE LIGAND BINDING RECEPTORS	93	4.69e-02	1.43e-01	0.09790	-0.013700	-0.096900	8.19e-01	1.06e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	286	1.09e-01	2.58e-01	0.09770	-0.069600	-0.068600	4.33e-02	4.63e-02
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	2.98e-01	4.85e-01	0.09750	0.095800	0.018400	2.89e-01	8.38e-01
FLT3 SIGNALING IN DISEASE	27	6.59e-01	7.86e-01	0.09650	-0.087300	-0.041000	4.32e-01	7.12e-01
TELOMERE MAINTENANCE	78	4.23e-02	1.33e-01	0.09600	-0.000552	-0.096000	9.93e-01	1.43e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	65	8.39e-02	2.17e-01	0.09540	-0.003330	-0.095300	9.63e-01	1.84e-01
GLYCOLYSIS	66	5.79e-01	7.24e-01	0.09540	0.074400	0.059600	2.96e-01	4.02e-01
ADAPTIVE IMMUNE SYSTEM	596	8.72e-03	3.85e-02	0.09500	-0.059400	-0.074100	1.36e-02	2.08e-03
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	4.63e-01	6.39e-01	0.09500	0.095000	-0.000473	4.74e-01	9.97e-01
INTERLEUKIN 17 SIGNALING	66	1.90e-01	3.73e-01	0.09500	0.022300	0.092300	7.54e-01	1.95e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	5.14e-01	6.75e-01	0.09430	-0.076600	-0.055100	2.55e-01	4.13e-01
RAB REGULATION OF TRAFFICKING	119	3.27e-01	5.14e-01	0.09410	0.053400	0.077600	3.15e-01	1.44e-01
RESOLUTION OF D LOOP STRUCTURES	30	1.33e-01	2.92e-01	0.09410	-0.081400	0.047100	4.40e-01	6.55e-01
TRNA AMINOACYLATION	42	5.10e-02	1.53e-01	0.09380	0.070100	-0.062300	4.32e-01	4.85e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	8.75e-01	9.20e-01	0.09350	-0.074300	-0.056900	6.07e-01	6.94e-01
FCGR3A MEDIATED IL10 SYNTHESIS	32	6.51e-01	7.79e-01	0.09350	0.042100	0.083500	6.80e-01	4.14e-01
BILE ACID AND BILE SALT METABOLISM	25	4.80e-01	6.54e-01	0.09320	0.014000	0.092100	9.04e-01	4.25e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	6.53e-01	7.80e-01	0.09270	-0.038500	-0.084300	7.19e-01	4.32e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	4.83e-01	6.55e-01	0.09270	0.089900	0.022600	3.86e-01	8.28e-01
SIGNALING BY ACTIVIN	12	4.44e-01	6.23e-01	0.09240	-0.054900	0.074300	7.42e-01	6.56e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	5.11e-01	6.73e-01	0.09160	-0.085100	-0.033900	3.46e-01	7.07e-01
RHOQ GTPASE CYCLE	57	4.17e-01	5.96e-01	0.09140	0.035700	0.084100	6.41e-01	2.72e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	43	6.77e-02	1.88e-01	0.09090	-0.045400	0.078700	6.07e-01	3.72e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	9.05e-01	9.41e-01	0.09080	-0.056000	-0.071500	7.27e-01	6.56e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	3.14e-01	5.00e-01	0.09060	-0.080300	0.041800	5.45e-01	7.52e-01
METAL ION SLC TRANSPORTERS	25	3.20e-01	5.06e-01	0.09040	-0.089300	0.014200	4.40e-01	9.02e-01
CELLULAR SENESCENCE	141	3.62e-01	5.47e-01	0.08970	0.069600	0.056600	1.54e-01	2.46e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	7.27e-01	8.29e-01	0.08970	0.089400	0.006040	6.24e-01	9.74e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	4.33e-01	6.13e-01	0.08940	-0.032700	-0.083100	6.80e-01	2.95e-01
FGFR2 ALTERNATIVE SPLICING	25	2.58e-01	4.46e-01	0.08910	0.031000	-0.083600	7.89e-01	4.69e-01
AMYLOID FIBER FORMATION	57	6.83e-02	1.89e-01	0.08910	0.087100	-0.018700	2.55e-01	8.07e-01
SYNTHESIS OF PC	25	8.28e-01	8.91e-01	0.08880	0.070700	0.053700	5.41e-01	6.42e-01
MITOTIC PROMETAPHASE	176	2.28e-01	4.15e-01	0.08870	-0.073300	-0.049900	9.38e-02	2.54e-01
PI3K EVENTS IN ERBB2 SIGNALING	14	4.14e-01	5.96e-01	0.08830	-0.060600	0.064200	6.95e-01	6.77e-01
PARASITE INFECTION	54	6.79e-01	7.97e-01	0.08830	0.054900	0.069100	4.86e-01	3.80e-01
NUCLEAR SIGNALING BY ERBB4	30	7.49e-01	8.47e-01	0.08820	0.045600	0.075500	6.65e-01	4.74e-01
OTHER INTERLEUKIN SIGNALING	19	5.72e-01	7.20e-01	0.08810	0.087700	0.008190	5.08e-01	9.51e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	43	6.02e-01	7.46e-01	0.08800	-0.039800	-0.078500	6.52e-01	3.73e-01
TELOMERE C STRAND SYNTHESIS INITIATION	13	5.14e-01	6.75e-01	0.08790	-0.083400	0.027800	6.03e-01	8.62e-01
SIGNALING BY SCF KIT	41	8.13e-02	2.13e-01	0.08750	-0.067700	0.055400	4.53e-01	5.40e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	2.04e-01	3.89e-01	0.08740	0.084300	-0.023100	4.02e-01	8.18e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	107	3.33e-02	1.11e-01	0.08720	-0.003070	-0.087200	9.56e-01	1.19e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	19	6.20e-01	7.59e-01	0.08720	-0.013900	-0.086100	9.16e-01	5.16e-01
G1 S SPECIFIC TRANSCRIPTION	26	2.80e-01	4.66e-01	0.08690	-0.083100	0.025500	4.63e-01	8.22e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	6.63e-01	7.87e-01	0.08660	0.084500	0.019200	5.24e-01	8.85e-01
ACYL CHAIN REMODELLING OF PG	10	8.70e-01	9.19e-01	0.08640	-0.079700	-0.033400	6.63e-01	8.55e-01
SIGNALING BY TGFB FAMILY MEMBERS	96	1.20e-01	2.75e-01	0.08590	-0.084100	-0.017500	1.55e-01	7.67e-01
METABOLISM OF VITAMINS AND COFACTORS	150	7.51e-02	2.01e-01	0.08560	0.081600	0.025700	8.47e-02	5.87e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	6.78e-01	7.97e-01	0.08540	-0.040800	-0.075000	6.63e-01	4.24e-01
GLYCOSPHINGOLIPID METABOLISM	39	1.55e-01	3.24e-01	0.08490	0.080600	-0.026800	3.84e-01	7.72e-01
DEFECTS IN COBALAMIN B12 METABOLISM	12	7.85e-01	8.65e-01	0.08480	-0.019900	-0.082500	9.05e-01	6.21e-01
POTASSIUM CHANNELS	90	5.79e-01	7.24e-01	0.08480	0.056600	0.063200	3.54e-01	3.01e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	8.79e-01	9.21e-01	0.08430	0.069600	0.047700	6.20e-01	7.34e-01
DISEASES OF PROGRAMMED CELL DEATH	54	1.70e-01	3.48e-01	0.08400	0.002270	-0.084000	9.77e-01	2.86e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	4.77e-01	6.52e-01	0.08400	-0.084000	0.001280	4.86e-01	9.92e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	4.86e-01	6.56e-01	0.08370	0.083300	-0.008120	5.19e-01	9.50e-01
SIGNALING BY NODAL	16	9.12e-01	9.44e-01	0.08360	0.059100	0.059100	6.82e-01	6.82e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	7.14e-01	8.19e-01	0.08340	0.016800	0.081700	9.07e-01	5.72e-01
RHO GTPASES ACTIVATE FORMINS	118	2.28e-01	4.15e-01	0.08310	-0.032800	-0.076400	5.39e-01	1.52e-01
RNA POLYMERASE II TRANSCRIPTION	1085	3.67e-05	3.67e-04	0.08280	-0.073300	-0.038500	5.26e-05	3.37e-02
PLATELET HOMEOSTASIS	78	5.64e-01	7.18e-01	0.08280	-0.068300	-0.046700	2.97e-01	4.76e-01
REGULATION OF KIT SIGNALING	16	4.83e-01	6.55e-01	0.08250	-0.026700	0.078100	8.53e-01	5.89e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	7.71e-01	8.60e-01	0.08230	-0.079200	-0.022400	5.95e-01	8.81e-01
SHC1 EVENTS IN ERBB2 SIGNALING	20	3.74e-01	5.58e-01	0.08200	-0.073700	0.035900	5.68e-01	7.81e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	6.23e-01	7.59e-01	0.08100	0.022900	0.077800	8.31e-01	4.69e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	3.59e-01	5.46e-01	0.08080	0.028000	-0.075800	8.16e-01	5.29e-01
HEDGEHOG OFF STATE	107	4.07e-03	2.11e-02	0.08020	0.051900	-0.061100	3.54e-01	2.75e-01
MTOR SIGNALLING	40	8.10e-01	8.78e-01	0.07990	-0.055400	-0.057500	5.44e-01	5.29e-01
BASE EXCISION REPAIR AP SITE FORMATION	29	2.95e-01	4.84e-01	0.07980	0.025000	-0.075800	8.16e-01	4.80e-01
GOLGI TO ER RETROGRADE TRANSPORT	119	4.14e-02	1.31e-01	0.07970	0.079600	0.002350	1.34e-01	9.65e-01
AMINO ACIDS REGULATE MTORC1	51	1.74e-01	3.53e-01	0.07950	0.010900	-0.078700	8.93e-01	3.31e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	4.80e-01	6.54e-01	0.07930	0.073800	0.029000	3.27e-01	7.00e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	1.17e-01	2.69e-01	0.07890	-0.059800	0.051400	4.97e-01	5.60e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	5.37e-01	6.92e-01	0.07850	-0.020100	-0.075900	8.30e-01	4.18e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	3.07e-01	4.94e-01	0.07830	0.028200	0.073100	6.33e-01	2.16e-01
DUAL INCISION IN GG NER	40	4.93e-01	6.60e-01	0.07830	-0.017400	-0.076300	8.49e-01	4.04e-01
RAP1 SIGNALLING	15	6.88e-01	8.02e-01	0.07830	-0.078200	-0.004110	6.00e-01	9.78e-01
SIGNALING BY MET	75	6.28e-01	7.60e-01	0.07830	0.045600	0.063600	4.95e-01	3.41e-01
INTERLEUKIN 35 SIGNALLING	10	6.79e-01	7.97e-01	0.07810	-0.075200	0.021100	6.81e-01	9.08e-01
GENE SILENCING BY RNA	82	4.41e-01	6.22e-01	0.07810	0.033500	0.070500	6.01e-01	2.70e-01
RHOG GTPASE CYCLE	73	6.01e-01	7.46e-01	0.07790	0.042100	0.065500	5.34e-01	3.33e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	6.23e-01	7.59e-01	0.07740	-0.063200	0.044800	7.29e-01	8.06e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	6.23e-01	7.59e-01	0.07740	-0.063200	0.044800	7.29e-01	8.06e-01
PRC2 METHYLATES HISTONES AND DNA	29	5.74e-01	7.20e-01	0.07700	-0.013200	-0.075900	9.02e-01	4.79e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	3.12e-01	5.00e-01	0.07690	-0.020800	-0.074000	7.52e-01	2.62e-01
NGF STIMULATED TRANSCRIPTION	37	2.24e-01	4.11e-01	0.07690	0.072000	-0.027000	4.49e-01	7.76e-01
HCMV LATE EVENTS	65	3.63e-01	5.47e-01	0.07660	0.074100	0.019500	3.02e-01	7.86e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	177	2.42e-02	8.49e-02	0.07650	-0.008780	-0.076000	8.41e-01	8.15e-02
MRNA CAPPING	29	7.15e-01	8.19e-01	0.07620	-0.027800	-0.071000	7.96e-01	5.08e-01
CARGO CONCENTRATION IN THE ER	30	7.17e-01	8.20e-01	0.07590	0.028500	0.070400	7.87e-01	5.05e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	7.95e-01	8.70e-01	0.07560	0.008570	0.075100	9.61e-01	6.66e-01
G ALPHA Z SIGNALLING EVENTS	45	6.36e-01	7.66e-01	0.07550	-0.030600	-0.069000	7.23e-01	4.23e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	2.87e-01	4.76e-01	0.07520	-0.009910	-0.074600	8.92e-01	3.06e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	16	4.82e-01	6.55e-01	0.07510	-0.054600	0.051700	7.05e-01	7.21e-01
SIGNALING BY FGFR2	62	2.53e-01	4.43e-01	0.07490	-0.005160	-0.074700	9.44e-01	3.09e-01
EPH EPHRIN SIGNALING	92	2.76e-01	4.64e-01	0.07460	0.071700	0.020600	2.35e-01	7.33e-01
SUMOYLATION	161	1.62e-03	1.01e-02	0.07440	-0.067100	0.032000	1.42e-01	4.84e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	3.98e-01	5.79e-01	0.07430	0.072400	0.017000	3.37e-01	8.21e-01
SIGNALING BY VEGF	101	5.71e-01	7.20e-01	0.07420	0.043400	0.060200	4.51e-01	2.96e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	8.65e-01	9.15e-01	0.07390	-0.064100	-0.036700	6.20e-01	7.76e-01
SIGNALING BY FGFR IN DISEASE	55	6.84e-01	8.01e-01	0.07380	-0.063500	-0.037600	4.16e-01	6.30e-01
NEGATIVE REGULATION OF MET ACTIVITY	21	7.36e-01	8.37e-01	0.07350	-0.071200	-0.018300	5.72e-01	8.84e-01
HYALURONAN UPTAKE AND DEGRADATION	11	6.23e-01	7.59e-01	0.07310	0.047500	-0.055500	7.85e-01	7.50e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	7.15e-02	1.94e-01	0.07300	0.056400	-0.046300	4.43e-01	5.29e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	47	1.78e-01	3.58e-01	0.07280	0.026800	-0.067700	7.51e-01	4.22e-01
REGULATION OF SIGNALING BY CBL	22	7.69e-01	8.60e-01	0.07270	-0.023300	-0.068900	8.50e-01	5.76e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	459	1.36e-01	2.97e-01	0.07270	0.048600	0.054000	7.51e-02	4.81e-02
REGULATION OF FZD BY UBIQUITINATION	19	7.12e-01	8.18e-01	0.07250	-0.010600	-0.071700	9.36e-01	5.88e-01
ERYTHROPOIETIN ACTIVATES RAS	13	9.38e-01	9.60e-01	0.07210	-0.057000	-0.044200	7.22e-01	7.83e-01
NUCLEOTIDE SALVAGE	21	4.16e-01	5.96e-01	0.07190	0.053600	-0.047900	6.71e-01	7.04e-01
EXTENSION OF TELOMERES	49	7.96e-01	8.70e-01	0.07170	-0.044900	-0.055800	5.86e-01	4.99e-01
SIGNALING BY HEDGEHOG	142	2.32e-02	8.25e-02	0.07140	0.071000	-0.007690	1.44e-01	8.74e-01
PTEN REGULATION	134	1.62e-01	3.34e-01	0.07140	-0.018000	-0.069100	7.20e-01	1.68e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	63	7.01e-01	8.10e-01	0.07130	-0.039300	-0.059400	5.89e-01	4.15e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	88	3.87e-02	1.25e-01	0.07090	0.063300	-0.031900	3.05e-01	6.05e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	4.68e-01	6.45e-01	0.07060	-0.025800	0.065700	8.34e-01	5.94e-01
VITAMIN B5 PANTOTHENATE METABOLISM	14	7.20e-01	8.22e-01	0.06960	-0.003750	0.069500	9.81e-01	6.52e-01
COPII MEDIATED VESICLE TRANSPORT	64	7.69e-01	8.60e-01	0.06940	0.052000	0.045900	4.72e-01	5.25e-01
BASE EXCISION REPAIR	56	1.76e-01	3.55e-01	0.06920	0.020400	-0.066100	7.92e-01	3.92e-01
FERTILIZATION	12	8.63e-01	9.15e-01	0.06900	-0.018600	-0.066500	9.11e-01	6.90e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	5.66e-01	7.18e-01	0.06880	0.017400	0.066600	8.40e-01	4.40e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	75	7.33e-01	8.34e-01	0.06880	-0.052600	-0.044300	4.31e-01	5.07e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	69	9.50e-02	2.35e-01	0.06810	0.060800	-0.030700	3.83e-01	6.59e-01
RESOLUTION OF ABASIC SITES AP SITES	37	5.83e-01	7.28e-01	0.06740	-0.011600	-0.066300	9.03e-01	4.85e-01
INTRAFLAGELLAR TRANSPORT	50	3.49e-01	5.37e-01	0.06720	0.067200	-0.001900	4.11e-01	9.81e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	6.60e-01	7.86e-01	0.06710	0.057400	-0.034900	7.31e-01	8.34e-01
SIGNALING BY WNT	268	7.92e-02	2.08e-01	0.06700	-0.022700	-0.063000	5.23e-01	7.63e-02
NUCLEOBASE BIOSYNTHESIS	15	5.84e-01	7.29e-01	0.06680	0.042800	-0.051300	7.74e-01	7.31e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	7.81e-01	8.63e-01	0.06670	0.015800	0.064800	9.03e-01	6.16e-01
RHOJ GTPASE CYCLE	54	4.74e-01	6.51e-01	0.06600	-0.064900	-0.011800	4.09e-01	8.81e-01
DEVELOPMENTAL BIOLOGY	813	5.15e-04	3.68e-03	0.06580	0.062400	0.021000	2.66e-03	3.11e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	23	5.92e-01	7.37e-01	0.06570	0.007530	-0.065300	9.50e-01	5.88e-01
GABA B RECEPTOR ACTIVATION	39	5.06e-01	6.69e-01	0.06570	-0.003600	-0.065600	9.69e-01	4.79e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	8.22e-01	8.85e-01	0.06560	-0.057100	-0.032400	5.65e-01	7.44e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	90	3.35e-01	5.24e-01	0.06550	-0.014900	-0.063700	8.07e-01	2.96e-01
SARS COV INFECTIONS	140	1.77e-02	6.66e-02	0.06540	0.022300	-0.061600	6.50e-01	2.09e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	9.12e-01	9.44e-01	0.06470	-0.027200	-0.058800	8.65e-01	7.14e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	16	6.31e-01	7.62e-01	0.06420	-0.059500	0.024000	6.80e-01	8.68e-01
RHOD GTPASE CYCLE	50	2.15e-01	4.03e-01	0.06390	-0.055700	0.031200	4.95e-01	7.03e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	20	9.04e-01	9.41e-01	0.06370	-0.054500	-0.033000	6.73e-01	7.99e-01
MAPK FAMILY SIGNALING CASCADES	286	2.52e-01	4.43e-01	0.06350	0.054100	0.033300	1.16e-01	3.34e-01
HIV TRANSCRIPTION ELONGATION	42	2.67e-01	4.55e-01	0.06250	0.046700	-0.041500	6.00e-01	6.42e-01
POTENTIAL THERAPEUTICS FOR SARS	77	1.41e-01	3.02e-01	0.06250	0.059600	-0.018900	3.66e-01	7.75e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	1.16e-01	2.69e-01	0.06240	-0.024000	0.057600	7.13e-01	3.76e-01
IRAK1 RECRUITS IKK COMPLEX	14	8.60e-01	9.12e-01	0.06210	0.060300	0.014600	6.96e-01	9.24e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	5.37e-01	6.92e-01	0.06200	-0.060000	0.015600	5.96e-01	8.90e-01
PLATELET SENSITIZATION BY LDL	15	9.46e-01	9.64e-01	0.06200	-0.037200	-0.049600	8.03e-01	7.39e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	62	2.40e-01	4.28e-01	0.06180	0.060200	-0.013800	4.12e-01	8.51e-01
ASPARAGINE N LINKED GLYCOSYLATION	282	1.93e-03	1.17e-02	0.06170	0.060400	-0.012600	8.13e-02	7.17e-01
DEUBIQUITINATION	243	4.36e-01	6.15e-01	0.06100	-0.048000	-0.037700	1.98e-01	3.13e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	6.11e-01	7.53e-01	0.06100	0.028400	0.054000	6.39e-01	3.74e-01
BASIGIN INTERACTIONS	23	5.25e-01	6.83e-01	0.06040	0.031500	-0.051600	7.94e-01	6.69e-01
ESR MEDIATED SIGNALING	163	5.74e-01	7.20e-01	0.06020	-0.036800	-0.047700	4.19e-01	2.94e-01
SIGNALING BY NOTCH	189	3.01e-01	4.87e-01	0.05990	0.054900	0.024000	1.94e-01	5.70e-01
DOWNREGULATION OF ERBB2 SIGNALING	27	8.77e-01	9.20e-01	0.05880	0.051700	0.028100	6.42e-01	8.00e-01
NICOTINAMIDE SALVAGING	15	9.54e-01	9.72e-01	0.05880	-0.037100	-0.045600	8.04e-01	7.60e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	5.29e-01	6.87e-01	0.05830	0.024300	-0.053100	8.30e-01	6.40e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	8.07e-01	8.78e-01	0.05810	0.006730	-0.057700	9.68e-01	7.29e-01
SIGNALING BY ERBB2	47	8.10e-01	8.78e-01	0.05790	-0.050400	-0.028600	5.50e-01	7.35e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	109	3.58e-01	5.46e-01	0.05790	0.056400	0.013400	3.10e-01	8.10e-01
SIGNALING BY FGFR	72	4.09e-01	5.92e-01	0.05780	-0.005770	-0.057500	9.33e-01	3.99e-01
RNA POLYMERASE I TRANSCRIPTION	67	1.92e-01	3.75e-01	0.05750	0.026900	-0.050900	7.03e-01	4.72e-01
RHOF GTPASE CYCLE	40	4.08e-01	5.92e-01	0.05750	-0.054000	0.019600	5.54e-01	8.30e-01
CELL CELL JUNCTION ORGANIZATION	50	8.33e-01	8.94e-01	0.05740	-0.047800	-0.031700	5.59e-01	6.98e-01
CLATHRIN MEDIATED ENDOCYTOSIS	130	6.26e-01	7.60e-01	0.05680	0.047500	0.031200	3.51e-01	5.39e-01
DISEASES OF IMMUNE SYSTEM	23	7.56e-01	8.50e-01	0.05660	0.056400	0.005150	6.40e-01	9.66e-01
REGULATION OF TP53 ACTIVITY	151	1.95e-01	3.79e-01	0.05640	0.008060	0.055800	8.64e-01	2.37e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	238	4.58e-01	6.35e-01	0.05580	0.031700	0.046000	4.01e-01	2.22e-01
POLO LIKE KINASE MEDIATED EVENTS	14	7.37e-01	8.37e-01	0.05580	-0.021300	0.051600	8.91e-01	7.38e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	7.88e-01	8.66e-01	0.05570	0.054900	0.009860	6.42e-01	9.33e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	1.58e-01	3.28e-01	0.05570	0.031600	-0.045800	6.34e-01	4.90e-01
ACYL CHAIN REMODELLING OF PC	17	9.57e-01	9.73e-01	0.05570	0.040900	0.037800	7.70e-01	7.87e-01
EPHB MEDIATED FORWARD SIGNALING	42	3.56e-01	5.45e-01	0.05570	0.044500	-0.033500	6.18e-01	7.07e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	8.54e-01	9.08e-01	0.05570	-0.055400	0.004870	7.61e-01	9.79e-01
OPIOID SIGNALLING	86	4.53e-01	6.31e-01	0.05540	-0.054200	-0.011200	3.85e-01	8.57e-01
SLC TRANSPORTER DISORDERS	74	2.58e-01	4.46e-01	0.05450	-0.013300	0.052900	8.43e-01	4.32e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	4.83e-01	6.55e-01	0.05440	0.000407	0.054400	9.96e-01	4.81e-01
TRNA PROCESSING IN THE NUCLEUS	56	3.77e-01	5.60e-01	0.05440	-0.011200	0.053200	8.85e-01	4.91e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	8.21e-01	8.85e-01	0.05440	0.030300	0.045200	6.83e-01	5.42e-01
SIGNALLING TO ERKS	32	9.24e-01	9.50e-01	0.05440	0.040000	0.036800	6.95e-01	7.19e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	8.48e-01	9.04e-01	0.05440	-0.017500	-0.051500	8.79e-01	6.56e-01
NUCLEOTIDE EXCISION REPAIR	109	5.00e-01	6.64e-01	0.05430	-0.018100	-0.051100	7.44e-01	3.57e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	3.50e-01	5.37e-01	0.05330	0.049700	0.019200	2.44e-01	6.53e-01
SIGNAL TRANSDUCTION BY L1	21	8.85e-01	9.27e-01	0.05310	0.049600	0.018700	6.94e-01	8.82e-01
RNA POLYMERASE III TRANSCRIPTION	41	7.50e-01	8.47e-01	0.05300	-0.014900	-0.050900	8.69e-01	5.73e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	7.13e-01	8.18e-01	0.05270	-0.052200	-0.007840	5.88e-01	9.35e-01
SIGNALING BY FGFR4	32	8.43e-01	9.01e-01	0.05260	-0.019700	-0.048800	8.47e-01	6.33e-01
GPVI MEDIATED ACTIVATION CASCADE	31	5.54e-01	7.06e-01	0.05230	0.048600	-0.019500	6.40e-01	8.51e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	8.47e-01	9.04e-01	0.05230	0.025000	0.046000	7.77e-01	6.02e-01
MITOTIC PROPHASE	94	4.15e-01	5.96e-01	0.05100	-0.050700	-0.005980	3.96e-01	9.20e-01
SIGNALING BY NTRK2 TRKB	24	6.55e-01	7.82e-01	0.05090	-0.047700	0.017700	6.86e-01	8.81e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	8.77e-01	9.20e-01	0.05050	0.046700	0.019100	6.74e-01	8.64e-01
IRS MEDIATED SIGNALLING	37	7.13e-01	8.18e-01	0.05040	-0.050100	-0.005990	5.98e-01	9.50e-01
NERVOUS SYSTEM DEVELOPMENT	547	6.65e-05	6.44e-04	0.05040	0.046100	-0.020400	6.60e-02	4.17e-01
HEMOSTASIS	474	5.75e-02	1.66e-01	0.05030	0.048200	0.014600	7.32e-02	5.88e-01
LEISHMANIA INFECTION	188	4.53e-01	6.31e-01	0.05010	0.045500	0.021000	2.83e-01	6.20e-01
METABOLISM OF STEROIDS	112	7.88e-01	8.66e-01	0.05010	-0.033300	-0.037400	5.43e-01	4.94e-01
INSULIN RECEPTOR SIGNALLING CASCADE	42	4.59e-01	6.35e-01	0.05000	-0.044400	0.023000	6.19e-01	7.96e-01
SNRNP ASSEMBLY	51	6.26e-01	7.60e-01	0.04980	-0.049600	-0.005220	5.40e-01	9.49e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	9.06e-01	9.41e-01	0.04980	0.037200	0.033100	6.59e-01	6.94e-01
RAC3 GTPASE CYCLE	88	2.29e-01	4.15e-01	0.04900	-0.018700	0.045200	7.62e-01	4.64e-01
CELL JUNCTION ORGANIZATION	74	7.98e-01	8.70e-01	0.04890	0.042100	0.024800	5.31e-01	7.13e-01
HDR THROUGH MMEJ ALT NHEJ	10	8.54e-01	9.08e-01	0.04870	-0.046200	0.015500	8.00e-01	9.32e-01
SIALIC ACID METABOLISM	32	6.99e-01	8.10e-01	0.04800	0.002750	-0.047900	9.78e-01	6.39e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	179	1.44e-01	3.06e-01	0.04790	0.047900	-0.002030	2.70e-01	9.63e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	60	5.40e-01	6.95e-01	0.04730	-0.000985	0.047300	9.89e-01	5.27e-01
SIGNALING BY NUCLEAR RECEPTORS	221	4.75e-01	6.51e-01	0.04710	-0.021200	-0.042100	5.88e-01	2.82e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	84	2.24e-01	4.11e-01	0.04710	0.033300	-0.033200	5.98e-01	5.99e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	6.46e-01	7.75e-01	0.04680	-0.045400	-0.011100	5.05e-01	8.71e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	9.38e-01	9.60e-01	0.04610	-0.034200	-0.030900	7.23e-01	7.48e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	5.16e-01	6.77e-01	0.04610	0.019600	-0.041700	8.24e-01	6.36e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	8.76e-01	9.20e-01	0.04510	-0.005330	-0.044800	9.69e-01	7.42e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	41	8.64e-01	9.15e-01	0.04490	0.018200	0.041100	8.40e-01	6.49e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	41	5.18e-01	6.79e-01	0.04480	-0.028200	0.034700	7.54e-01	7.00e-01
REGULATION OF INSULIN SECRETION	71	8.43e-01	9.01e-01	0.04450	0.023300	0.038000	7.34e-01	5.80e-01
HOMOLOGY DIRECTED REPAIR	107	8.35e-01	8.94e-01	0.04450	-0.029200	-0.033500	6.01e-01	5.50e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	7.75e-01	8.60e-01	0.04400	-0.043900	-0.001260	6.72e-01	9.90e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	7.65e-01	8.58e-01	0.04390	-0.000252	0.043900	9.98e-01	6.72e-01
ENDOGENOUS STEROLS	20	8.90e-01	9.29e-01	0.04340	-0.008190	-0.042600	9.49e-01	7.42e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	92	8.11e-01	8.79e-01	0.04320	0.022500	0.036800	7.09e-01	5.42e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	92	5.34e-01	6.91e-01	0.04310	0.004540	0.042800	9.40e-01	4.78e-01
RAC2 GTPASE CYCLE	86	3.05e-01	4.92e-01	0.04280	-0.021100	0.037200	7.35e-01	5.51e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	52	6.31e-01	7.62e-01	0.04250	-0.002620	0.042500	9.74e-01	5.96e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	7.62e-01	8.55e-01	0.04230	-0.041500	0.008320	7.14e-01	9.42e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	6.87e-01	8.02e-01	0.04220	-0.020600	0.036800	8.50e-01	7.36e-01
VXPX CARGO TARGETING TO CILIUM	19	7.67e-01	8.59e-01	0.04210	-0.034200	0.024600	7.96e-01	8.53e-01
RAF ACTIVATION	34	9.32e-01	9.56e-01	0.04180	-0.022200	-0.035400	8.23e-01	7.21e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	280	5.70e-01	7.20e-01	0.04150	0.022100	0.035100	5.26e-01	3.13e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	9.76e-01	9.85e-01	0.04140	-0.036300	-0.019800	8.42e-01	9.13e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	29	9.03e-01	9.41e-01	0.04100	-0.014200	-0.038500	8.95e-01	7.20e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	27	7.82e-01	8.63e-01	0.04080	0.005830	-0.040400	9.58e-01	7.16e-01
GPCR LIGAND BINDING	243	1.46e-01	3.10e-01	0.04080	0.040700	-0.002040	2.75e-01	9.56e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	11	9.85e-01	9.92e-01	0.04050	-0.028300	-0.029000	8.71e-01	8.68e-01
NUCLEAR ENVELOPE NE REASSEMBLY	64	4.89e-01	6.57e-01	0.03980	0.036500	-0.015800	6.14e-01	8.28e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	9.30e-01	9.55e-01	0.03960	-0.007640	-0.038800	9.59e-01	7.95e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	9.62e-01	9.75e-01	0.03950	0.017600	0.035400	9.03e-01	8.06e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	223	6.46e-02	1.81e-01	0.03930	0.029500	-0.025900	4.48e-01	5.05e-01
CILIUM ASSEMBLY	190	2.53e-01	4.43e-01	0.03920	-0.001650	0.039100	9.69e-01	3.53e-01
TRANSPORT OF SMALL MOLECULES	569	1.17e-01	2.69e-01	0.03880	0.037400	0.010400	1.29e-01	6.74e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	88	3.45e-01	5.33e-01	0.03870	-0.027300	0.027400	6.58e-01	6.57e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	179	5.13e-01	6.75e-01	0.03820	0.010300	0.036800	8.13e-01	3.96e-01
MET RECEPTOR RECYCLING	10	9.35e-01	9.57e-01	0.03740	0.002010	-0.037300	9.91e-01	8.38e-01
MEMBRANE TRAFFICKING	576	4.15e-01	5.96e-01	0.03710	0.031200	0.020200	2.03e-01	4.10e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	8.74e-01	9.20e-01	0.03710	0.032500	-0.018000	8.39e-01	9.11e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	8.55e-01	9.08e-01	0.03690	-0.031800	0.018800	8.31e-01	9.00e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	25	8.76e-01	9.20e-01	0.03630	0.036200	0.002170	7.54e-01	9.85e-01
VESICLE MEDIATED TRANSPORT	604	2.32e-01	4.20e-01	0.03630	0.033500	0.013800	1.61e-01	5.65e-01
METABOLISM OF LIPIDS	609	2.98e-01	4.85e-01	0.03610	0.032400	0.015900	1.74e-01	5.05e-01
TELOMERE EXTENSION BY TELOMERASE	22	9.17e-01	9.47e-01	0.03580	0.006980	0.035100	9.55e-01	7.75e-01
SURFACTANT METABOLISM	17	9.62e-01	9.75e-01	0.03560	0.032700	0.014100	8.15e-01	9.20e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	7.02e-01	8.10e-01	0.03530	0.033700	-0.010300	6.99e-01	9.06e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	35	7.05e-01	8.13e-01	0.03520	-0.024200	0.025500	8.04e-01	7.94e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	364	5.11e-01	6.73e-01	0.03460	0.015300	0.031000	6.18e-01	3.11e-01
RHO GTPASE EFFECTORS	245	1.31e-01	2.91e-01	0.03430	0.013800	-0.031400	7.10e-01	3.98e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	9.70e-01	9.80e-01	0.03380	0.018100	0.028600	8.81e-01	8.13e-01
SYNDECAN INTERACTIONS	26	7.93e-01	8.69e-01	0.03370	0.019200	-0.027700	8.65e-01	8.07e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	7.73e-01	8.60e-01	0.03350	0.007110	0.032700	9.14e-01	6.17e-01
TRANSCRIPTIONAL REGULATION BY TP53	342	7.44e-01	8.44e-01	0.03260	-0.023500	-0.022600	4.56e-01	4.73e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	8.92e-01	9.30e-01	0.03210	0.028500	-0.014700	8.49e-01	9.21e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	9.18e-01	9.47e-01	0.03200	0.001950	-0.031900	9.89e-01	8.20e-01
AURKA ACTIVATION BY TPX2	71	6.97e-01	8.10e-01	0.03150	-0.002980	0.031300	9.65e-01	6.48e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	9.64e-01	9.77e-01	0.03130	-0.018400	-0.025300	8.46e-01	7.90e-01
SPHINGOLIPID METABOLISM	80	7.70e-01	8.60e-01	0.03080	-0.004320	-0.030500	9.47e-01	6.37e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	13	9.19e-01	9.47e-01	0.03070	-0.028500	0.011200	8.59e-01	9.44e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	22	8.48e-01	9.04e-01	0.03050	0.020000	-0.022900	8.71e-01	8.52e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	6.01e-01	7.46e-01	0.03030	-0.006580	0.029500	9.13e-01	6.23e-01
TIGHT JUNCTION INTERACTIONS	19	9.66e-01	9.77e-01	0.02970	0.010300	0.027900	9.38e-01	8.34e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	9.76e-01	9.85e-01	0.02900	-0.006180	-0.028400	9.73e-01	8.77e-01
TOLL LIKE RECEPTOR CASCADES	137	9.13e-01	9.45e-01	0.02810	-0.020900	-0.018800	6.73e-01	7.04e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	163	4.87e-01	6.57e-01	0.02700	0.026300	-0.006240	5.63e-01	8.91e-01
CELLULAR RESPONSE TO HEAT STRESS	94	7.45e-01	8.44e-01	0.02650	0.000132	-0.026500	9.98e-01	6.58e-01
DNA DOUBLE STRAND BREAK RESPONSE	52	8.20e-01	8.85e-01	0.02620	0.004140	-0.025800	9.59e-01	7.47e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	103	9.07e-01	9.41e-01	0.02550	0.022600	0.011900	6.92e-01	8.35e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	29	9.82e-01	9.89e-01	0.02490	-0.014500	-0.020300	8.93e-01	8.50e-01
ESTROGEN DEPENDENT GENE EXPRESSION	102	7.84e-01	8.65e-01	0.02470	-0.001810	-0.024600	9.75e-01	6.67e-01
NEUROTRANSMITTER RELEASE CYCLE	47	9.21e-01	9.49e-01	0.02460	0.005430	0.024000	9.49e-01	7.76e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	8.26e-01	8.89e-01	0.02410	0.004410	-0.023700	9.54e-01	7.57e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	9.62e-01	9.75e-01	0.02390	0.005920	-0.023100	9.73e-01	8.94e-01
MITOCHONDRIAL BIOGENESIS	92	7.56e-01	8.50e-01	0.02230	0.005280	-0.021700	9.30e-01	7.19e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	57	8.01e-01	8.73e-01	0.02220	0.017900	-0.013200	8.16e-01	8.64e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1213	4.77e-01	6.52e-01	0.02140	-0.010100	-0.018900	5.58e-01	2.73e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	9.69e-01	9.80e-01	0.02120	-0.005990	0.020300	9.73e-01	9.07e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	85	9.09e-01	9.42e-01	0.02020	-0.019600	-0.004780	7.55e-01	9.39e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	282	6.44e-01	7.74e-01	0.01940	0.000624	0.019400	9.86e-01	5.77e-01
FLT3 SIGNALING	37	9.89e-01	9.92e-01	0.01900	-0.014300	-0.012400	8.80e-01	8.96e-01
SENSORY PERCEPTION	148	9.16e-01	9.47e-01	0.01860	0.016900	0.007670	7.23e-01	8.72e-01
UNWINDING OF DNA	12	9.94e-01	9.95e-01	0.01850	0.016200	0.008870	9.23e-01	9.58e-01
VISUAL PHOTOTRANSDUCTION	60	9.54e-01	9.72e-01	0.01740	0.016800	0.004670	8.22e-01	9.50e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	9.39e-01	9.60e-01	0.01730	0.008240	-0.015200	9.40e-01	8.89e-01
SIGNALING BY FGFR3	35	9.41e-01	9.61e-01	0.01580	0.005780	-0.014700	9.53e-01	8.80e-01
G ALPHA Q SIGNALLING EVENTS	145	7.96e-01	8.70e-01	0.01560	-0.014900	0.004660	7.58e-01	9.23e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	29	9.59e-01	9.75e-01	0.01550	0.003200	-0.015200	9.76e-01	8.87e-01
G ALPHA I SIGNALLING EVENTS	189	8.07e-01	8.78e-01	0.01530	0.001010	-0.015200	9.81e-01	7.19e-01
DNA REPAIR	291	7.52e-01	8.49e-01	0.01520	-0.015200	-0.000372	6.55e-01	9.91e-01
MEIOTIC SYNAPSIS	39	9.92e-01	9.95e-01	0.01520	-0.009620	-0.011800	9.17e-01	8.99e-01
ACYL CHAIN REMODELLING OF PE	16	9.86e-01	9.92e-01	0.01460	-0.000811	-0.014600	9.96e-01	9.19e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	90	9.27e-01	9.52e-01	0.01420	-0.000536	-0.014200	9.93e-01	8.16e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	9.95e-01	9.95e-01	0.01050	-0.008580	-0.005980	9.18e-01	9.43e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	9.88e-01	9.92e-01	0.00996	0.009850	-0.001460	9.35e-01	9.90e-01
DNA DOUBLE STRAND BREAK REPAIR	136	9.88e-01	9.92e-01	0.00892	-0.007500	-0.004830	8.80e-01	9.23e-01
TRNA PROCESSING	105	9.99e-01	9.99e-01	0.00218	0.001080	0.001890	9.85e-01	9.73e-01

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Detailed Gene set reports

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

metric	value
setSize	12
pMANOVA	0.000473
p.adjustMANOVA	0.00346
s.dist	0.841
s.LPS	-0.53
s.OVA	-0.652
p.LPS	0.00146
p.OVA	9.11e-05

Top 20 genes

Gene	LPS	OVA
Spcs2	-8004	-8233
Spcs3	-7865	-7688
Dpp4	-7065	-7783
Pcsk1	-7249	-6380
Spcs1	-5579	-6577
Sec11a	-3692	-6344
Sec11c	-3673	-5156
Tcf7l2	-2870	-3804
Pax6	-1816	-3325
Grp	-1309	-4577
Ctnnb1	-2282	-2544

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ctnnb1	-2282	-2544
Dpp4	-7065	-7783
Gng13	874	-2150
Grp	-1309	-4577
Pax6	-1816	-3325
Pcsk1	-7249	-6380
Sec11a	-3692	-6344
Sec11c	-3673	-5156
Spcs1	-5579	-6577
Spcs2	-8004	-8233
Spcs3	-7865	-7688
Tcf7l2	-2870	-3804

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INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

metric	value
setSize	13
pMANOVA	0.000293
p.adjustMANOVA	0.00224
s.dist	0.828
s.LPS	-0.517
s.OVA	-0.646
p.LPS	0.00124
p.OVA	5.52e-05

Top 20 genes

Gene	LPS	OVA
Spcs2	-8004	-8233
Spcs3	-7865	-7688
Dpp4	-7065	-7783
Pcsk1	-7249	-6380
Spcs1	-5579	-6577
Sec11a	-3692	-6344
Sec11c	-3673	-5156
Isl1	-2779	-4672
Tcf7l2	-2870	-3804
Pax6	-1816	-3325
Grp	-1309	-4577
Ctnnb1	-2282	-2544

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ctnnb1	-2282	-2544
Dpp4	-7065	-7783
Gng13	874	-2150
Grp	-1309	-4577
Isl1	-2779	-4672
Pax6	-1816	-3325
Pcsk1	-7249	-6380
Sec11a	-3692	-6344
Sec11c	-3673	-5156
Spcs1	-5579	-6577
Spcs2	-8004	-8233
Spcs3	-7865	-7688
Tcf7l2	-2870	-3804

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TERMINATION OF O GLYCAN BIOSYNTHESIS

TERMINATION OF O GLYCAN BIOSYNTHESIS

metric	value
setSize	10
pMANOVA	0.0133
p.adjustMANOVA	0.0537
s.dist	0.718
s.LPS	0.527
s.OVA	0.488
p.LPS	0.00392
p.OVA	0.00749

Top 20 genes

Gene	LPS	OVA
St3gal3	8596	7890
St6galnac2	8045	7731
St6galnac4	7848	4960
St3gal2	7036	5092
St3gal1	4016	7099
Muc3a	3662	5077
St6galnac3	3340	3369
Muc6	4004	2045

Click HERE to show all gene set members

All member genes

	LPS	OVA
Muc3a	3662	5077
Muc6	4004	2045
St3gal1	4016	7099
St3gal2	7036	5092
St3gal3	8596	7890
St3gal4	2129	-435
St6gal1	-2003	-838
St6galnac2	8045	7731
St6galnac3	3340	3369
St6galnac4	7848	4960

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SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

metric	value
setSize	12
pMANOVA	0.00657
p.adjustMANOVA	0.0311
s.dist	0.696
s.LPS	-0.455
s.OVA	-0.527
p.LPS	0.00639
p.OVA	0.00158

Top 20 genes

Gene	LPS	OVA
Spcs2	-8004	-8233
Spcs3	-7865	-7688
Pla2g7	-7284	-8141
Pcsk1	-7249	-6380
Spcs1	-5579	-6577
Bche	-6160	-5703
Igf1	-6894	-3486
Sec11a	-3692	-6344
Sec11c	-3673	-5156

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ache	7273	4404
Bche	-6160	-5703
Crhr2	3223	3699
Igf1	-6894	-3486
Klf4	3012	-2292
Pcsk1	-7249	-6380
Pla2g7	-7284	-8141
Sec11a	-3692	-6344
Sec11c	-3673	-5156
Spcs1	-5579	-6577
Spcs2	-8004	-8233
Spcs3	-7865	-7688

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ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY

metric	value
setSize	10
pMANOVA	0.0172
p.adjustMANOVA	0.0653
s.dist	0.694
s.LPS	0.467
s.OVA	0.514
p.LPS	0.0106
p.OVA	0.00491

Top 20 genes

Gene	LPS	OVA
Adcy6	7846	8264
Adcy4	7443	7481
Adcy1	6225	7797
Adcy5	7191	6031
Adcy3	6162	6198
Adcy9	3746	5934
Gnal	2338	1937
Adcy7	496	5699

Click HERE to show all gene set members

All member genes

	LPS	OVA
Adcy1	6225	7797
Adcy2	1741	-1351
Adcy3	6162	6198
Adcy4	7443	7481
Adcy5	7191	6031
Adcy6	7846	8264
Adcy7	496	5699
Adcy8	-1543	-3876
Adcy9	3746	5934
Gnal	2338	1937

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APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION

metric	value
setSize	10
pMANOVA	0.0225
p.adjustMANOVA	0.0804
s.dist	0.678
s.LPS	-0.482
s.OVA	-0.477
p.LPS	0.00832
p.OVA	0.00907

Top 20 genes

Gene	LPS	OVA
Hmgb1	-7984	-8175
H1f2	-7844	-8289
H1f0	-7400	-8124
Casp3	-7215	-8208
Hmgb2	-5352	-7827
Kpna1	-7594	-5401
H1f4	-5921	-5760

Click HERE to show all gene set members

All member genes

	LPS	OVA
Casp3	-7215	-8208
Dffa	7112	5919
Dffb	6004	5618
H1f0	-7400	-8124
H1f2	-7844	-8289
H1f4	-5921	-5760
Hmgb1	-7984	-8175
Hmgb2	-5352	-7827
Kpna1	-7594	-5401
Kpnb1	-1839	1205

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CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY

metric	value
setSize	11
pMANOVA	0.0181
p.adjustMANOVA	0.0678
s.dist	0.656
s.LPS	-0.439
s.OVA	-0.488
p.LPS	0.0117
p.OVA	0.00508

Top 20 genes

Gene	LPS	OVA
Cdc42	-8072	-8187
Pak1	-6861	-8065
Pak3	-7891	-6805
Pak2	-6917	-4954
Rac1	-4940	-5756
Cd86	-3440	-4967
Cd80	-2930	-2853
Grb2	-1143	-2755

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cd80	-2930	-2853
Cd86	-3440	-4967
Cdc42	-8072	-8187
Fyn	1063	990
Grb2	-1143	-2755
Lck	1370	-1777
Pak1	-6861	-8065
Pak2	-6917	-4954
Pak3	-7891	-6805
Rac1	-4940	-5756
Vav1	1898	1134

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SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

metric	value
setSize	29
pMANOVA	2.17e-05
p.adjustMANOVA	0.000228
s.dist	0.639
s.LPS	-0.402
s.OVA	-0.497
p.LPS	0.00018
p.OVA	3.58e-06

Top 20 genes

Gene	LPS	OVA
Ube2e1	-7960	-8023
Ube2b	-7679	-8116
Ube2d1	-7736	-8049
Ube2k	-8002	-7743
Ube2l3	-7415	-8056
Ube2w	-7938	-7438
Ube2d2a	-6979	-8072
Ube2e3	-7434	-7420
Ube2g1	-7670	-7056
Ube2a	-6990	-7587
Ube2q2	-7811	-6616
Ube2r2	-4347	-7333
Uchl3	-5104	-6156
Rps27a	-4151	-6446
Ube2t	-2638	-7098
Uba6	-6159	-2842
Usp9x	-7159	-2078
Otulin	-3285	-3769
Usp7	-3130	-406

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cdc34	2933	-1517
Otulin	-3285	-3769
Rps27a	-4151	-6446
Uba1	3160	2268
Uba52	1246	-3922
Uba6	-6159	-2842
Ubb	5592	-1688
Ubc	4950	173
Ube2a	-6990	-7587
Ube2b	-7679	-8116
Ube2d1	-7736	-8049
Ube2d2a	-6979	-8072
Ube2e1	-7960	-8023
Ube2e3	-7434	-7420
Ube2g1	-7670	-7056
Ube2g2	6338	5624
Ube2h	-2978	1772
Ube2k	-8002	-7743
Ube2l3	-7415	-8056
Ube2q2	-7811	-6616
Ube2r2	-4347	-7333
Ube2s	509	-3327
Ube2t	-2638	-7098
Ube2w	-7938	-7438
Ube2z	2304	982
Uchl3	-5104	-6156
Usp5	4834	1821
Usp7	-3130	-406
Usp9x	-7159	-2078

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CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS

metric	value
setSize	15
pMANOVA	0.00419
p.adjustMANOVA	0.0214
s.dist	0.639
s.LPS	0.493
s.OVA	0.406
p.LPS	0.000937
p.OVA	0.00646

Top 20 genes

Gene	LPS	OVA
Pxdn	7327	8345
Loxl3	7645	7425
Col4a2	6176	6207
Loxl1	8247	4169
Col4a1	5565	5825
Col4a3	3771	7472
Bmp1	5174	4539
Col4a5	4191	5165
Tll2	4692	2626
Col1a1	6151	1839
Col4a4	2341	4532
Pcolce	7297	66

Click HERE to show all gene set members

All member genes

	LPS	OVA
Bmp1	5174	4539
Col1a1	6151	1839
Col1a2	2456	-2665
Col4a1	5565	5825
Col4a2	6176	6207
Col4a3	3771	7472
Col4a4	2341	4532
Col4a5	4191	5165
Loxl1	8247	4169
Loxl2	-2777	-1036
Loxl3	7645	7425
Pcolce	7297	66
Pxdn	7327	8345
Tll1	-2464	-1902
Tll2	4692	2626

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GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

metric	value
setSize	31
pMANOVA	2.31e-08
p.adjustMANOVA	4.92e-07
s.dist	0.627
s.LPS	-0.295
s.OVA	-0.553
p.LPS	0.00447
p.OVA	9.6e-08

Top 20 genes

Gene	LPS	OVA
Cdc42	-8072	-8187
Tcp1	-7623	-8207
Rap1b	-7859	-7820
Hnrnpdl	-6738	-7873
Pdcd4	-7509	-6937
Hnrnpa2b1	-7014	-7327
Rala	-6902	-7384
Hspa9	-6630	-7411
Ppia	-4873	-7794
Capza1	-6506	-5748
Pak2	-6917	-4954
Mtap	-3884	-6769
Rplp0	-2961	-8015
Sod2	-6103	-3718
Psme2	-3439	-6535
Hnrnpf	-4212	-4629
Snrpa1	-3603	-5177
Lcp1	-2724	-5799
Pitpna	-2644	-1681
Gsto1	-779	-5498

Click HERE to show all gene set members

All member genes

	LPS	OVA
Aip	4000	-2593
Anxa2	5321	502
Arf1	2085	-556
Bola2	4079	-8
Capza1	-6506	-5748
Cdc42	-8072	-8187
Cfl1	4853	-2988
Cnn2	51	-4976
Gsto1	-779	-5498
Hnrnpa2b1	-7014	-7327
Hnrnpdl	-6738	-7873
Hnrnpf	-4212	-4629
Hspa9	-6630	-7411
Lcp1	-2724	-5799
Lmnb1	2923	1452
Mif	7925	3959
Msn	-491	-1247
Mtap	-3884	-6769
Pak2	-6917	-4954
Pdcd4	-7509	-6937
Pitpna	-2644	-1681
Ppia	-4873	-7794
Psme2	-3439	-6535
Rala	-6902	-7384
Rap1b	-7859	-7820
Rplp0	-2961	-8015
Snrpa1	-3603	-5177
Sod1	3519	-3184
Sod2	-6103	-3718
Taldo1	3561	-3776
Tcp1	-7623	-8207

---

---

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

metric	value
setSize	13
pMANOVA	0.0149
p.adjustMANOVA	0.0585
s.dist	0.606
s.LPS	0.464
s.OVA	0.389
p.LPS	0.00374
p.OVA	0.0153

Top 20 genes

Gene	LPS	OVA
Ndor1	8331	8471
Ercc2	8598	7716
Mms19	7655	7760
Nubp1	7690	6684
Ciao3	7550	5677
Rtel1	5315	6272
Pold1	6009	4493
Ciapin1	4369	3802
Ciao2b	3894	106
Ciao1	1931	140

Click HERE to show all gene set members

All member genes

	LPS	OVA
Abcb7	-7667	-5144
Brip1	-4757	-2173
Ciao1	1931	140
Ciao2b	3894	106
Ciao3	7550	5677
Ciapin1	4369	3802
Ercc2	8598	7716
Mms19	7655	7760
Ndor1	8331	8471
Nubp1	7690	6684
Nubp2	4943	-123
Pold1	6009	4493
Rtel1	5315	6272

---

---

PROCESSING AND ACTIVATION OF SUMO

PROCESSING AND ACTIVATION OF SUMO

metric	value
setSize	10
pMANOVA	0.0296
p.adjustMANOVA	0.1
s.dist	0.598
s.LPS	-0.481
s.OVA	-0.356
p.LPS	0.00849
p.OVA	0.0515

Top 20 genes

Gene	LPS	OVA
Sumo2	-7592	-8114
Sumo1	-7690	-7606
Rwdd3	-6476	-4334
Ube2i	-5430	-1977
Sumo3	-1631	-4747
Uba2	-3118	-2238
Sae1	-1001	-5690
Senp5	-4297	-144

Click HERE to show all gene set members

All member genes

	LPS	OVA
Rwdd3	-6476	-4334
Sae1	-1001	-5690
Senp1	2845	3832
Senp2	-3542	2121
Senp5	-4297	-144
Sumo1	-7690	-7606
Sumo2	-7592	-8114
Sumo3	-1631	-4747
Uba2	-3118	-2238
Ube2i	-5430	-1977

---

---

ACTIVATION OF SMO

ACTIVATION OF SMO

metric	value
setSize	16
pMANOVA	0.00913
p.adjustMANOVA	0.04
s.dist	0.594
s.LPS	0.432
s.OVA	0.408
p.LPS	0.00279
p.OVA	0.00473

Top 20 genes

Gene	LPS	OVA
Arrb2	8346	7960
Evc2	8119	7588
Smo	7752	7576
Boc	6718	6894
Iqce	6874	6612
Gas8	6950	5763
Evc	7312	5188
Grk2	7604	4985
Arrb1	4508	5192
Cdon	2793	5940
Gas1	6425	1435
Ptch1	1767	4882

Click HERE to show all gene set members

All member genes

	LPS	OVA
Arrb1	4508	5192
Arrb2	8346	7960
Boc	6718	6894
Cdon	2793	5940
Csnk1a1	-6609	-2303
Efcab7	-5222	-5613
Evc	7312	5188
Evc2	8119	7588
Gas1	6425	1435
Gas8	6950	5763
Grk2	7604	4985
Iqce	6874	6612
Kif3a	-1359	-2280
Ptch1	1767	4882
Shh	-83	-3463
Smo	7752	7576

---

---

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

metric	value
setSize	59
pMANOVA	4.01e-19
p.adjustMANOVA	2.34e-17
s.dist	0.589
s.LPS	-0.207
s.OVA	-0.552
p.LPS	0.00593
p.OVA	2.23e-13

Top 20 genes

Gene	LPS	OVA
Rps18	-8130	-8305
Eif4a2	-8151	-8223
Eif3j2	-7973	-8155
Eif2s2	-7828	-8273
Eif3e	-7918	-8151
Eif4e	-7931	-8105
Eif2s1	-7854	-8028
Rps7	-7425	-8293
Eif3m	-7110	-7951
Eif1ax	-7995	-6665
Rps2	-6487	-7717
Eif2s3x	-7524	-6599
Rps3a1	-4714	-7196
Eif4b	-5660	-5708
Rps4x	-4466	-7050
Rps24	-4142	-7540
Pabpc1	-4248	-7276
Eif3a	-4921	-5962
Rps27a	-4151	-6446
Rps3	-3359	-6570

Click HERE to show all gene set members

All member genes

	LPS	OVA
Eif1ax	-7995	-6665
Eif2s1	-7854	-8028
Eif2s2	-7828	-8273
Eif2s3x	-7524	-6599
Eif3a	-4921	-5962
Eif3b	5878	3019
Eif3c	3368	-2690
Eif3d	3254	-2320
Eif3e	-7918	-8151
Eif3f	3235	-1728
Eif3g	-209	-5266
Eif3h	-2198	-7075
Eif3i	4160	280
Eif3j1	-3806	-4106
Eif3j2	-7973	-8155
Eif3k	3181	-2407
Eif3l	5085	2364
Eif3m	-7110	-7951
Eif4a1	-394	-4167
Eif4a2	-8151	-8223
Eif4b	-5660	-5708
Eif4e	-7931	-8105
Eif4ebp1	902	-3330
Eif4g1	4138	3921
Eif4h	4064	1575
Fau	2620	-3235
Pabpc1	-4248	-7276
Rps10	1539	-4274
Rps11	539	-4477
Rps12	3920	-1797
Rps13	-3077	-6001
Rps14	-1149	-6092
Rps15	2979	-2178
Rps15a	-263	-3337
Rps16	-1649	-5137
Rps17	355	-3810
Rps18	-8130	-8305
Rps19	-304	-4694
Rps2	-6487	-7717
Rps20	789	-5035
Rps21	1676	-1411
Rps23	-2519	-6491
Rps24	-4142	-7540
Rps25	-1835	-5671
Rps26	726	-3827
Rps27	256	-3603
Rps27a	-4151	-6446
Rps27l	-3637	-5926
Rps28	4824	2397
Rps29	5536	3958
Rps3	-3359	-6570
Rps3a1	-4714	-7196
Rps4x	-4466	-7050
Rps5	2415	-3011
Rps6	-2212	-6729
Rps7	-7425	-8293
Rps8	-2385	-6533
Rps9	-1060	-5311
Rpsa	1252	-4509

---

---

EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION

metric	value
setSize	87
pMANOVA	1.08e-38
p.adjustMANOVA	4.22e-36
s.dist	0.587
s.LPS	-0.128
s.OVA	-0.573
p.LPS	0.0395
p.OVA	2.39e-20

Top 20 genes

Gene	LPS	OVA
Rps18	-8130	-8305
Rps7	-7425	-8293
Rpl22l1	-7570	-8090
Rpl35a	-7115	-8275
Rpl30	-6706	-8242
Rpl5	-6827	-7989
Rps2	-6487	-7717
Eef1g	-5451	-7596
Rpl3	-5307	-7372
Rpl27a	-4837	-7755
Rps3a1	-4714	-7196
Rpl15	-4648	-7094
Rpl29	-4310	-7539
Rpl24	-4859	-6682
Rps4x	-4466	-7050
Rps24	-4142	-7540
Rpl6	-4396	-6936
Rpl26	-4005	-7477
Rps27a	-4151	-6446
Rpl36a	-3373	-7573

Click HERE to show all gene set members

All member genes

	LPS	OVA
Eef1a1	-435	-5725
Eef1a2	4945	-995
Eef1b2	-2894	-6751
Eef1d	4917	-1533
Eef1g	-5451	-7596
Eef2	5946	-743
Fau	2620	-3235
Rpl10	2424	507
Rpl10a	991	-4758
Rpl11	-2505	-6265
Rpl12	3956	941
Rpl13	3375	-1929
Rpl13a	-2547	-6497
Rpl14	-3851	-6213
Rpl15	-4648	-7094
Rpl17	-3127	-6495
Rpl18	2994	-2908
Rpl18a	304	-5493
Rpl19	1011	-3676
Rpl21	1147	-4966
Rpl22	-4097	-6119
Rpl22l1	-7570	-8090
Rpl23	-2534	-5395
Rpl23a	-428	-5507
Rpl24	-4859	-6682
Rpl26	-4005	-7477
Rpl27	-285	-4949
Rpl27a	-4837	-7755
Rpl28	1738	-3911
Rpl29	-4310	-7539
Rpl3	-5307	-7372
Rpl30	-6706	-8242
Rpl31	108	-5140
Rpl32	552	-3620
Rpl34	2271	-2980
Rpl35	1205	-1839
Rpl35a	-7115	-8275
Rpl36	4587	-161
Rpl36a	-3373	-7573
Rpl36al	1237	-4874
Rpl37	3844	143
Rpl37a	2789	-3065
Rpl38	4255	1284
Rpl39	520	-2708
Rpl4	-3201	-6174
Rpl5	-6827	-7989
Rpl6	-4396	-6936
Rpl7	-3881	-6564
Rpl7a	1582	-4322
Rpl8	2864	-2597
Rpl9	-3187	-6715
Rplp0	-2961	-8015
Rplp1	2427	-2664
Rplp2	3909	-422
Rps10	1539	-4274
Rps11	539	-4477
Rps12	3920	-1797
Rps13	-3077	-6001
Rps14	-1149	-6092
Rps15	2979	-2178
Rps15a	-263	-3337
Rps16	-1649	-5137
Rps17	355	-3810
Rps18	-8130	-8305
Rps19	-304	-4694
Rps2	-6487	-7717
Rps20	789	-5035
Rps21	1676	-1411
Rps23	-2519	-6491
Rps24	-4142	-7540
Rps25	-1835	-5671
Rps26	726	-3827
Rps27	256	-3603
Rps27a	-4151	-6446
Rps27l	-3637	-5926
Rps28	4824	2397
Rps29	5536	3958
Rps3	-3359	-6570
Rps3a1	-4714	-7196
Rps4x	-4466	-7050
Rps5	2415	-3011
Rps6	-2212	-6729
Rps7	-7425	-8293
Rps8	-2385	-6533
Rps9	-1060	-5311
Rpsa	1252	-4509
Uba52	1246	-3922

---

---

CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING

metric	value
setSize	16
pMANOVA	0.00213
p.adjustMANOVA	0.0126
s.dist	0.585
s.LPS	0.321
s.OVA	0.489
p.LPS	0.0263
p.OVA	0.000713

Top 20 genes

Gene	LPS	OVA
Dpysl5	7607	8352
Plxna3	8053	7849
Dpysl4	8231	7528
Plxna1	7406	8163
Fes	7782	7170
Crmp1	7096	6078
Plxna4	4595	6882
Nrp1	3781	5959
Plxna2	2437	6912
Cdk5	6378	2545
Fyn	1063	990

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cdk5	6378	2545
Cdk5r1	-2860	-299
Crmp1	7096	6078
Dpysl2	-161	2837
Dpysl3	-3245	-1612
Dpysl4	8231	7528
Dpysl5	7607	8352
Fes	7782	7170
Fyn	1063	990
Gsk3b	-5313	-134
Nrp1	3781	5959
Plxna1	7406	8163
Plxna2	2437	6912
Plxna3	8053	7849
Plxna4	4595	6882
Sema3a	-5852	-2019

---

---

SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION

SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION

metric	value
setSize	14
pMANOVA	0.0151
p.adjustMANOVA	0.059
s.dist	0.577
s.LPS	0.365
s.OVA	0.447
p.LPS	0.018
p.OVA	0.00378

Top 20 genes

Gene	LPS	OVA
Plxna3	8053	7849
Plxna1	7406	8163
Tln1	8297	7196
Fes	7782	7170
Pip5k1c	7427	6778
Plxna4	4595	6882
Nrp1	3781	5959
Plxna2	2437	6912
Farp2	1706	4863
Rras	4439	1688
Fyn	1063	990

Click HERE to show all gene set members

All member genes

	LPS	OVA
Farp2	1706	4863
Fes	7782	7170
Fyn	1063	990
Nrp1	3781	5959
Pip5k1c	7427	6778
Plxna1	7406	8163
Plxna2	2437	6912
Plxna3	8053	7849
Plxna4	4595	6882
Rac1	-4940	-5756
Rnd1	145	-2759
Rras	4439	1688
Sema3a	-5852	-2019
Tln1	8297	7196

---

---

EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION

metric	value
setSize	114
pMANOVA	3.89e-40
p.adjustMANOVA	2.27e-37
s.dist	0.573
s.LPS	-0.168
s.OVA	-0.548
p.LPS	0.00202
p.OVA	4.8e-24

Top 20 genes

Gene	LPS	OVA
Rps18	-8130	-8305
Eif4a2	-8151	-8223
Eif5	-8119	-8162
Eif3j2	-7973	-8155
Eif2s2	-7828	-8273
Eif3e	-7918	-8151
Eif4e	-7931	-8105
Eif2s1	-7854	-8028
Eif5b	-7555	-8246
Rps7	-7425	-8293
Rpl22l1	-7570	-8090
Rpl35a	-7115	-8275
Eif3m	-7110	-7951
Rpl30	-6706	-8242
Rpl5	-6827	-7989
Eif1ax	-7995	-6665
Rps2	-6487	-7717
Eif2s3x	-7524	-6599
Rpl3	-5307	-7372
Rpl27a	-4837	-7755

Click HERE to show all gene set members

All member genes

	LPS	OVA
Eif1ax	-7995	-6665
Eif2b1	3110	2524
Eif2b2	7724	6781
Eif2b3	-4488	-6796
Eif2b4	5924	2097
Eif2b5	4974	-2553
Eif2s1	-7854	-8028
Eif2s2	-7828	-8273
Eif2s3x	-7524	-6599
Eif3a	-4921	-5962
Eif3b	5878	3019
Eif3c	3368	-2690
Eif3d	3254	-2320
Eif3e	-7918	-8151
Eif3f	3235	-1728
Eif3g	-209	-5266
Eif3h	-2198	-7075
Eif3i	4160	280
Eif3j1	-3806	-4106
Eif3j2	-7973	-8155
Eif3k	3181	-2407
Eif3l	5085	2364
Eif3m	-7110	-7951
Eif4a1	-394	-4167
Eif4a2	-8151	-8223
Eif4b	-5660	-5708
Eif4e	-7931	-8105
Eif4ebp1	902	-3330
Eif4g1	4138	3921
Eif4h	4064	1575
Eif5	-8119	-8162
Eif5b	-7555	-8246
Fau	2620	-3235
Pabpc1	-4248	-7276
Rpl10	2424	507
Rpl10a	991	-4758
Rpl11	-2505	-6265
Rpl12	3956	941
Rpl13	3375	-1929
Rpl13a	-2547	-6497
Rpl14	-3851	-6213
Rpl15	-4648	-7094
Rpl17	-3127	-6495
Rpl18	2994	-2908
Rpl18a	304	-5493
Rpl19	1011	-3676
Rpl21	1147	-4966
Rpl22	-4097	-6119
Rpl22l1	-7570	-8090
Rpl23	-2534	-5395
Rpl23a	-428	-5507
Rpl24	-4859	-6682
Rpl26	-4005	-7477
Rpl27	-285	-4949
Rpl27a	-4837	-7755
Rpl28	1738	-3911
Rpl29	-4310	-7539
Rpl3	-5307	-7372
Rpl30	-6706	-8242
Rpl31	108	-5140
Rpl32	552	-3620
Rpl34	2271	-2980
Rpl35	1205	-1839
Rpl35a	-7115	-8275
Rpl36	4587	-161
Rpl36a	-3373	-7573
Rpl36al	1237	-4874
Rpl37	3844	143
Rpl37a	2789	-3065
Rpl38	4255	1284
Rpl39	520	-2708
Rpl4	-3201	-6174
Rpl5	-6827	-7989
Rpl6	-4396	-6936
Rpl7	-3881	-6564
Rpl7a	1582	-4322
Rpl8	2864	-2597
Rpl9	-3187	-6715
Rplp0	-2961	-8015
Rplp1	2427	-2664
Rplp2	3909	-422
Rps10	1539	-4274
Rps11	539	-4477
Rps12	3920	-1797
Rps13	-3077	-6001
Rps14	-1149	-6092
Rps15	2979	-2178
Rps15a	-263	-3337
Rps16	-1649	-5137
Rps17	355	-3810
Rps18	-8130	-8305
Rps19	-304	-4694
Rps2	-6487	-7717
Rps20	789	-5035
Rps21	1676	-1411
Rps23	-2519	-6491
Rps24	-4142	-7540
Rps25	-1835	-5671
Rps26	726	-3827
Rps27	256	-3603
Rps27a	-4151	-6446
Rps27l	-3637	-5926
Rps28	4824	2397
Rps29	5536	3958
Rps3	-3359	-6570
Rps3a1	-4714	-7196
Rps4x	-4466	-7050
Rps5	2415	-3011
Rps6	-2212	-6729
Rps7	-7425	-8293
Rps8	-2385	-6533
Rps9	-1060	-5311
Rpsa	1252	-4509
Uba52	1246	-3922

---

---

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

metric	value
setSize	106
pMANOVA	1.58e-35
p.adjustMANOVA	3.7e-33
s.dist	0.568
s.LPS	-0.173
s.OVA	-0.541
p.LPS	0.00208
p.OVA	6.32e-22

Top 20 genes

Gene	LPS	OVA
Rps18	-8130	-8305
Spcs2	-8004	-8233
Rps7	-7425	-8293
Rpl22l1	-7570	-8090
Spcs3	-7865	-7688
Srp54a	-7590	-7828
Rpl35a	-7115	-8275
Ssr1	-7954	-7116
Ssr3	-7793	-7262
Rpl30	-6706	-8242
Rpl5	-6827	-7989
Rps2	-6487	-7717
Srp19	-5666	-7555
Sec61g	-6200	-6698
Rpl3	-5307	-7372
Rpl27a	-4837	-7755
Spcs1	-5579	-6577
Rps3a1	-4714	-7196
Rpl15	-4648	-7094
Rpl29	-4310	-7539

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ddost	3975	189
Fau	2620	-3235
Rpl10	2424	507
Rpl10a	991	-4758
Rpl11	-2505	-6265
Rpl12	3956	941
Rpl13	3375	-1929
Rpl13a	-2547	-6497
Rpl14	-3851	-6213
Rpl15	-4648	-7094
Rpl17	-3127	-6495
Rpl18	2994	-2908
Rpl18a	304	-5493
Rpl19	1011	-3676
Rpl21	1147	-4966
Rpl22	-4097	-6119
Rpl22l1	-7570	-8090
Rpl23	-2534	-5395
Rpl23a	-428	-5507
Rpl24	-4859	-6682
Rpl26	-4005	-7477
Rpl27	-285	-4949
Rpl27a	-4837	-7755
Rpl28	1738	-3911
Rpl29	-4310	-7539
Rpl3	-5307	-7372
Rpl30	-6706	-8242
Rpl31	108	-5140
Rpl32	552	-3620
Rpl34	2271	-2980
Rpl35	1205	-1839
Rpl35a	-7115	-8275
Rpl36	4587	-161
Rpl36a	-3373	-7573
Rpl36al	1237	-4874
Rpl37	3844	143
Rpl37a	2789	-3065
Rpl38	4255	1284
Rpl39	520	-2708
Rpl4	-3201	-6174
Rpl5	-6827	-7989
Rpl6	-4396	-6936
Rpl7	-3881	-6564
Rpl7a	1582	-4322
Rpl8	2864	-2597
Rpl9	-3187	-6715
Rplp0	-2961	-8015
Rplp1	2427	-2664
Rplp2	3909	-422
Rpn1	1261	-4152
Rpn2	4493	-241
Rps10	1539	-4274
Rps11	539	-4477
Rps12	3920	-1797
Rps13	-3077	-6001
Rps14	-1149	-6092
Rps15	2979	-2178
Rps15a	-263	-3337
Rps16	-1649	-5137
Rps17	355	-3810
Rps18	-8130	-8305
Rps19	-304	-4694
Rps2	-6487	-7717
Rps20	789	-5035
Rps21	1676	-1411
Rps23	-2519	-6491
Rps24	-4142	-7540
Rps25	-1835	-5671
Rps26	726	-3827
Rps27	256	-3603
Rps27a	-4151	-6446
Rps27l	-3637	-5926
Rps28	4824	2397
Rps29	5536	3958
Rps3	-3359	-6570
Rps3a1	-4714	-7196
Rps4x	-4466	-7050
Rps5	2415	-3011
Rps6	-2212	-6729
Rps7	-7425	-8293
Rps8	-2385	-6533
Rps9	-1060	-5311
Rpsa	1252	-4509
Sec11a	-3692	-6344
Sec11c	-3673	-5156
Sec61a1	8160	7263
Sec61a2	-205	1759
Sec61b	-198	-2903
Sec61g	-6200	-6698
Spcs1	-5579	-6577
Spcs2	-8004	-8233
Spcs3	-7865	-7688
Srp14	-3345	-6670
Srp19	-5666	-7555
Srp54a	-7590	-7828
Srp68	5874	6000
Srp72	-4722	-2693
Srp9	-4213	-6014
Srpr	3249	2683
Srprb	4576	130
Ssr1	-7954	-7116
Ssr2	2082	-2416
Ssr3	-7793	-7262
Ssr4	1240	-2666
Tram1	-6914	-3190
Uba52	1246	-3922

---

---

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

metric	value
setSize	10
pMANOVA	0.0708
p.adjustMANOVA	0.192
s.dist	0.563
s.LPS	-0.383
s.OVA	-0.412
p.LPS	0.0359
p.OVA	0.024

Top 20 genes

Gene	LPS	OVA
Ywhab	-7666	-7998
Ywhae	-7717	-7897
Ywhaq	-7028	-8249
Ywhaz	-7536	-6155
Chek2	-4877	-5886
Ywhah	-2652	-6922
Chek1	-2083	-3036

Click HERE to show all gene set members

All member genes

	LPS	OVA
Chek1	-2083	-3036
Chek2	-4877	-5886
Sfn	5926	6682
Wee1	-1035	942
Ywhab	-7666	-7998
Ywhae	-7717	-7897
Ywhag	4921	4872
Ywhah	-2652	-6922
Ywhaq	-7028	-8249
Ywhaz	-7536	-6155

---

---

NRAGE SIGNALS DEATH THROUGH JNK

NRAGE SIGNALS DEATH THROUGH JNK

metric	value
setSize	55
pMANOVA	1.46e-07
p.adjustMANOVA	2.54e-06
s.dist	0.559
s.LPS	0.348
s.OVA	0.437
p.LPS	8.08e-06
p.OVA	2.04e-08

Top 20 genes

Gene	LPS	OVA
Arhgef10	8005	8237
Arhgef5	8080	8094
Arhgef4	8317	7840
Plekhg5	8197	7941
Plekhg2	7996	8128
Arhgef18	7825	7800
Vav2	7277	8344
Arhgef17	7804	7676
Mcf2l	7256	8174
Obscn	6928	8366
Arhgef2	7503	7653
Arhgef1	7309	7632
Arhgef7	7227	7683
Prex1	7906	6914
Arhgef11	7310	7427
Abr	6956	7403
Arhgef40	7431	6884
Fgd1	7753	6519
Arhgef10l	7914	6369
Kalrn	6510	7737

Click HERE to show all gene set members

All member genes

	LPS	OVA
Aatf	813	989
Abr	6956	7403
Akap13	5814	7841
Arhgef1	7309	7632
Arhgef10	8005	8237
Arhgef10l	7914	6369
Arhgef11	7310	7427
Arhgef12	2142	6206
Arhgef15	3329	-3859
Arhgef16	3069	2396
Arhgef17	7804	7676
Arhgef18	7825	7800
Arhgef19	7205	6679
Arhgef2	7503	7653
Arhgef26	442	1952
Arhgef3	-2851	1619
Arhgef33	4095	5549
Arhgef37	373	4162
Arhgef4	8317	7840
Arhgef40	7431	6884
Arhgef5	8080	8094
Arhgef6	3312	6044
Arhgef7	7227	7683
Arhgef9	-3514	441
Bad	6722	-372
Bcl2l11	-588	-1031
Fgd1	7753	6519
Fgd2	4918	5410
Fgd3	5702	1877
Fgd4	-6723	-316
Gna13	-1920	937
Itsn1	4988	6273
Kalrn	6510	7737
Maged1	3563	2749
Mapk8	-7571	-5665
Mcf2	-6006	-6537
Mcf2l	7256	8174
Net1	-3807	120
Ngef	1287	-1222
Ngf	4685	1637
Ngfr	-1273	-5306
Obscn	6928	8366
Plekhg2	7996	8128
Plekhg5	8197	7941
Prex1	7906	6914
Rac1	-4940	-5756
Rasgrf2	4351	7214
Sos1	-5267	-258
Sos2	-5539	-1950
Tiam1	2545	5178
Tiam2	-856	3365
Trio	5357	7477
Vav1	1898	1134
Vav2	7277	8344
Vav3	-3584	-1058

---

---

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

metric	value
setSize	94
pMANOVA	5.19e-33
p.adjustMANOVA	8.68e-31
s.dist	0.556
s.LPS	-0.151
s.OVA	-0.535
p.LPS	0.0115
p.OVA	2.93e-19

Top 20 genes

Gene	LPS	OVA
Rps18	-8130	-8305
Eif2s2	-7828	-8273
Eif2s1	-7854	-8028
Rps7	-7425	-8293
Rpl22l1	-7570	-8090
Cebpg	-7908	-7731
Rpl35a	-7115	-8275
Rpl30	-6706	-8242
Rpl5	-6827	-7989
Rps2	-6487	-7717
Eif2s3x	-7524	-6599
Impact	-7873	-6221
Atf2	-7751	-5390
Rpl3	-5307	-7372
Rpl27a	-4837	-7755
Rps3a1	-4714	-7196
Rpl15	-4648	-7094
Rpl29	-4310	-7539
Rpl24	-4859	-6682
Rps4x	-4466	-7050

Click HERE to show all gene set members

All member genes

	LPS	OVA
Asns	-4905	-6301
Atf2	-7751	-5390
Atf3	1030	-1046
Atf4	4881	-346
Cebpb	7945	6784
Cebpg	-7908	-7731
Ddit3	7049	204
Eif2ak4	5311	8230
Eif2s1	-7854	-8028
Eif2s2	-7828	-8273
Eif2s3x	-7524	-6599
Fau	2620	-3235
Gcn1	8529	8420
Impact	-7873	-6221
Rpl10	2424	507
Rpl10a	991	-4758
Rpl11	-2505	-6265
Rpl12	3956	941
Rpl13	3375	-1929
Rpl13a	-2547	-6497
Rpl14	-3851	-6213
Rpl15	-4648	-7094
Rpl17	-3127	-6495
Rpl18	2994	-2908
Rpl18a	304	-5493
Rpl19	1011	-3676
Rpl21	1147	-4966
Rpl22	-4097	-6119
Rpl22l1	-7570	-8090
Rpl23	-2534	-5395
Rpl23a	-428	-5507
Rpl24	-4859	-6682
Rpl26	-4005	-7477
Rpl27	-285	-4949
Rpl27a	-4837	-7755
Rpl28	1738	-3911
Rpl29	-4310	-7539
Rpl3	-5307	-7372
Rpl30	-6706	-8242
Rpl31	108	-5140
Rpl32	552	-3620
Rpl34	2271	-2980
Rpl35	1205	-1839
Rpl35a	-7115	-8275
Rpl36	4587	-161
Rpl36a	-3373	-7573
Rpl36al	1237	-4874
Rpl37	3844	143
Rpl37a	2789	-3065
Rpl38	4255	1284
Rpl39	520	-2708
Rpl4	-3201	-6174
Rpl5	-6827	-7989
Rpl6	-4396	-6936
Rpl7	-3881	-6564
Rpl7a	1582	-4322
Rpl8	2864	-2597
Rpl9	-3187	-6715
Rplp0	-2961	-8015
Rplp1	2427	-2664
Rplp2	3909	-422
Rps10	1539	-4274
Rps11	539	-4477
Rps12	3920	-1797
Rps13	-3077	-6001
Rps14	-1149	-6092
Rps15	2979	-2178
Rps15a	-263	-3337
Rps16	-1649	-5137
Rps17	355	-3810
Rps18	-8130	-8305
Rps19	-304	-4694
Rps2	-6487	-7717
Rps20	789	-5035
Rps21	1676	-1411
Rps23	-2519	-6491
Rps24	-4142	-7540
Rps25	-1835	-5671
Rps26	726	-3827
Rps27	256	-3603
Rps27a	-4151	-6446
Rps27l	-3637	-5926
Rps28	4824	2397
Rps29	5536	3958
Rps3	-3359	-6570
Rps3a1	-4714	-7196
Rps4x	-4466	-7050
Rps5	2415	-3011
Rps6	-2212	-6729
Rps7	-7425	-8293
Rps8	-2385	-6533
Rps9	-1060	-5311
Rpsa	1252	-4509
Uba52	1246	-3922

---

---

SYNAPTIC ADHESION LIKE MOLECULES

SYNAPTIC ADHESION LIKE MOLECULES

metric	value
setSize	21
pMANOVA	0.00382
p.adjustMANOVA	0.02
s.dist	0.554
s.LPS	0.362
s.OVA	0.419
p.LPS	0.00406
p.OVA	0.000885

Top 20 genes

Gene	LPS	OVA
Ptprs	8485	8456
Grin2c	8520	8171
Grin1	8383	8071
Grin2d	8015	7109
Ptprf	7532	7556
Lrfn2	7220	7365
Lrfn1	8142	5659
Lrfn4	8242	5515
Flot2	7150	4803
Lrfn3	7439	4318
Dlg4	6434	4819
Gria1	3655	5558
Flot1	4877	2098
Dlg3	2867	2705
Grin2a	982	7072
Grin2b	1076	5954

Click HERE to show all gene set members

All member genes

	LPS	OVA
Dlg1	-7124	-5969
Dlg3	2867	2705
Dlg4	6434	4819
Flot1	4877	2098
Flot2	7150	4803
Gria1	3655	5558
Gria3	-6641	-1071
Gria4	-6450	-6168
Grin1	8383	8071
Grin2a	982	7072
Grin2b	1076	5954
Grin2c	8520	8171
Grin2d	8015	7109
Lrfn1	8142	5659
Lrfn2	7220	7365
Lrfn3	7439	4318
Lrfn4	8242	5515
Ptprd	-3396	787
Ptprf	7532	7556
Ptprs	8485	8456
Rtn3	-6456	-6900

---

---

COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN

metric	value
setSize	10
pMANOVA	0.000494
p.adjustMANOVA	0.00354
s.dist	0.554
s.LPS	-0.531
s.OVA	-0.157
p.LPS	0.00363
p.OVA	0.389

Top 20 genes

Gene	LPS	OVA
Smc3	-7944	-7952
Rad21	-7700	-7071
Stag2	-7545	-4624
Smc1a	-3179	-3968
Wapl	-5842	-1401
Stag1	-4158	-1106
Pds5b	-6317	-701

Click HERE to show all gene set members

All member genes

	LPS	OVA
Mau2	8610	8498
Nipbl	-4828	1846
Pds5a	-3266	4251
Pds5b	-6317	-701
Rad21	-7700	-7071
Smc1a	-3179	-3968
Smc3	-7944	-7952
Stag1	-4158	-1106
Stag2	-7545	-4624
Wapl	-5842	-1401

---

---

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

metric	value
setSize	19
pMANOVA	0.00221
p.adjustMANOVA	0.0129
s.dist	0.552
s.LPS	-0.314
s.OVA	-0.453
p.LPS	0.0177
p.OVA	0.000621

Top 20 genes

Gene	LPS	OVA
P2ry12	-7204	-7400
Gnai3	-6909	-7168
Gng12	-6644	-7142
Gng11	-5717	-8201
Gnai1	-6633	-6255
Gng10	-5616	-7169
Gnb4	-5892	-5361
Gng2	-7333	-4079
Gnb1	-5182	-5068
Gng5	-4101	-4343
Gng4	-2566	-2443
Gng3	-1007	-3994

Click HERE to show all gene set members

All member genes

	LPS	OVA
Gnai1	-6633	-6255
Gnai2	4743	470
Gnai3	-6909	-7168
Gnb1	-5182	-5068
Gnb2	6733	2146
Gnb4	-5892	-5361
Gnb5	1596	-445
Gng10	-5616	-7169
Gng11	-5717	-8201
Gng12	-6644	-7142
Gng13	874	-2150
Gng2	-7333	-4079
Gng3	-1007	-3994
Gng4	-2566	-2443
Gng5	-4101	-4343
Gng7	4482	2541
Gng8	846	908
Gngt2	30	-5315
P2ry12	-7204	-7400

---

---

PROTEIN METHYLATION

PROTEIN METHYLATION

metric	value
setSize	17
pMANOVA	0.00136
p.adjustMANOVA	0.0087
s.dist	0.54
s.LPS	-0.268
s.OVA	-0.469
p.LPS	0.0557
p.OVA	0.000809

Top 20 genes

Gene	LPS	OVA
Calm1	-7789	-8217
Rps2	-6487	-7717
Eef1akmt2	-6807	-7224
Kin	-4854	-7177
Vcpkmt	-3985	-7174
Etfbkmt	-5146	-5213
Vcp	-2647	-6321
Etfb	-2465	-5341
Camkmt	-3870	-2748
Hspa8	-1270	-7868
Mettl21a	-4417	-1882
Eef1a1	-435	-5725

Click HERE to show all gene set members

All member genes

	LPS	OVA
Calm1	-7789	-8217
Camkmt	-3870	-2748
Eef1a1	-435	-5725
Eef1akmt1	1257	-4700
Eef1akmt2	-6807	-7224
Eef2	5946	-743
Eef2kmt	2909	2311
Etfb	-2465	-5341
Etfbkmt	-5146	-5213
Hspa8	-1270	-7868
Kin	-4854	-7177
Mettl21a	-4417	-1882
Mettl22	6246	5332
Prmt3	-297	5098
Rps2	-6487	-7717
Vcp	-2647	-6321
Vcpkmt	-3985	-7174

---

---

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

metric	value
setSize	10
pMANOVA	0.038
p.adjustMANOVA	0.125
s.dist	0.538
s.LPS	0.294
s.OVA	0.45
p.LPS	0.107
p.OVA	0.0137

Top 20 genes

Gene	LPS	OVA
Slit1	8332	8342
Src	8214	7957
Slit3	5953	6990
Nell2	6156	5271
Robo3	4449	3230
Ntn1	4246	3080
Robo1	1075	4273

Click HERE to show all gene set members

All member genes

	LPS	OVA
Dcc	-2818	2105
Nell2	6156	5271
Ntn1	4246	3080
Robo1	1075	4273
Robo2	-2641	1876
Robo3	4449	3230
Slit1	8332	8342
Slit2	-5836	-4362
Slit3	5953	6990
Src	8214	7957

---

---

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

metric	value
setSize	17
pMANOVA	0.00363
p.adjustMANOVA	0.0193
s.dist	0.527
s.LPS	0.28
s.OVA	0.447
p.LPS	0.0455
p.OVA	0.00143

Top 20 genes

Gene	LPS	OVA
Src	8214	7957
Mov10	7342	8224
Pml	6835	7065
Ptpn11	6123	6036
Ago1	4775	7003
Ago2	4451	7396
Ccnd3	7747	3446
Tnrc6c	2918	7475
Cdk6	2166	5993
Ago3	1717	7044
Ccnd2	3993	2955
Tnrc6a	113	5662

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ago1	4775	7003
Ago2	4451	7396
Ago3	1717	7044
Ago4	-2337	-3780
Cbfb	-7186	-4490
Ccnd1	-1471	-5085
Ccnd2	3993	2955
Ccnd3	7747	3446
Cdk6	2166	5993
Mov10	7342	8224
Pml	6835	7065
Ptpn11	6123	6036
Runx1	-1056	-2880
Src	8214	7957
Tnrc6a	113	5662
Tnrc6b	-222	5399
Tnrc6c	2918	7475

---

---

COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS

metric	value
setSize	56
pMANOVA	1.5e-16
p.adjustMANOVA	8.35e-15
s.dist	0.515
s.LPS	-0.149
s.OVA	-0.493
p.LPS	0.0546
p.OVA	1.69e-10

Top 20 genes

Gene	LPS	OVA
mt-Nd3	-7874	-8166
Ndufv2	-7326	-8174
Ndufc2	-6810	-8133
Ndufaf2	-6865	-7985
Ndufaf4	-6918	-7760
Ndufaf1	-7033	-7464
Ndufs4	-6419	-7730
mt-Nd2	-6413	-7640
mt-Nd1	-6074	-7724
Ndufb4	-5840	-7565
mt-Nd6	-6017	-6995
mt-Nd4	-5657	-7297
mt-Nd5	-5992	-6663
Ndufb5	-5144	-6998
Nubpl	-5268	-6351
Ndufaf5	-4413	-7120
Ndufc1	-4784	-6440
Ndufb6	-3958	-6724
Ndufs1	-5457	-4813
Ndufa9	-4215	-6209

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acad9	1997	1412
Ecsit	7341	5389
mt-Nd1	-6074	-7724
mt-Nd2	-6413	-7640
mt-Nd3	-7874	-8166
mt-Nd4	-5657	-7297
mt-Nd5	-5992	-6663
mt-Nd6	-6017	-6995
Ndufa1	965	-2318
Ndufa10	-2857	-7639
Ndufa11	6108	753
Ndufa12	-1350	-5830
Ndufa13	5331	-109
Ndufa2	3798	114
Ndufa3	6144	3394
Ndufa5	-2848	-5699
Ndufa6	1534	-3931
Ndufa7	3623	-913
Ndufa8	-2090	-6239
Ndufa9	-4215	-6209
Ndufab1	2826	-1605
Ndufaf1	-7033	-7464
Ndufaf2	-6865	-7985
Ndufaf3	3747	-996
Ndufaf4	-6918	-7760
Ndufaf5	-4413	-7120
Ndufaf6	26	-4369
Ndufaf7	-5794	-2627
Ndufb1	457	-1830
Ndufb10	4607	92
Ndufb11	1375	-4660
Ndufb2	734	-5007
Ndufb3	-1524	-5998
Ndufb4	-5840	-7565
Ndufb5	-5144	-6998
Ndufb6	-3958	-6724
Ndufb7	4620	-668
Ndufb8	3270	-4532
Ndufb9	-1641	-5834
Ndufc1	-4784	-6440
Ndufc2	-6810	-8133
Ndufs1	-5457	-4813
Ndufs2	220	-6044
Ndufs3	-419	-3522
Ndufs4	-6419	-7730
Ndufs5	-164	-5224
Ndufs6	-957	-4958
Ndufs7	6908	2926
Ndufs8	5988	-3675
Ndufv1	3480	-2422
Ndufv2	-7326	-8174
Ndufv3	5345	1298
Nubpl	-5268	-6351
Timmdc1	-82	-1635
Tmem126b	-2541	-4507
Tmem186	4284	5440

---

---

EARLY PHASE OF HIV LIFE CYCLE

EARLY PHASE OF HIV LIFE CYCLE

metric	value
setSize	13
pMANOVA	0.0521
p.adjustMANOVA	0.154
s.dist	0.515
s.LPS	-0.339
s.OVA	-0.387
p.LPS	0.0344
p.OVA	0.0156

Top 20 genes

Gene	LPS	OVA
Psip1	-7852	-8153
Xrcc5	-7450	-7499
Xrcc4	-6692	-7585
Ccr5	-5665	-7552
Kpna1	-7594	-5401
Ppia	-4873	-7794
Lig4	-5815	-4769
Xrcc6	-2281	-35

Click HERE to show all gene set members

All member genes

	LPS	OVA
Banf1	1758	-2543
Ccr5	-5665	-7552
Cxcr4	2211	-1631
Fen1	-374	1428
Hmga1	6774	6859
Kpna1	-7594	-5401
Lig1	4021	3673
Lig4	-5815	-4769
Ppia	-4873	-7794
Psip1	-7852	-8153
Xrcc4	-6692	-7585
Xrcc5	-7450	-7499
Xrcc6	-2281	-35

---

---

POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY

metric	value
setSize	17
pMANOVA	2.82e-10
p.adjustMANOVA	9.17e-09
s.dist	0.512
s.LPS	0.511
s.OVA	-0.0335
p.LPS	0.000265
p.OVA	0.811

Top 20 genes

Gene	LPS	OVA
Tuba1b	6002	-3366
Tuba4a	4457	-3395
Tuba1a	4327	-3116
Tbcb	3297	-3946
Tubb6	6723	-1503
Tubb4b	7725	-813
Tbcc	1406	-2663
Tuba8	1016	-1883

Click HERE to show all gene set members

All member genes

	LPS	OVA
Arl2	6749	42
Tbca	-6605	-7082
Tbcb	3297	-3946
Tbcc	1406	-2663
Tbcd	8112	7664
Tbce	-2703	-2820
Tuba1a	4327	-3116
Tuba1b	6002	-3366
Tuba1c	7230	8325
Tuba4a	4457	-3395
Tuba8	1016	-1883
Tubb2a	7755	4663
Tubb2b	5462	1609
Tubb3	7736	434
Tubb4a	8354	4731
Tubb4b	7725	-813
Tubb6	6723	-1503

---

---

TRIGLYCERIDE CATABOLISM

TRIGLYCERIDE CATABOLISM

metric	value
setSize	14
pMANOVA	0.0092
p.adjustMANOVA	0.04
s.dist	0.51
s.LPS	-0.258
s.OVA	-0.44
p.LPS	0.0946
p.OVA	0.00438

Top 20 genes

Gene	LPS	OVA
Fabp7	-7382	-8241
Prkacb	-7699	-7589
Ppp1cb	-8086	-7047
Abhd5	-5682	-6275
Gpd2	-6603	-5396
Fabp5	-4419	-7170
Ppp1cc	-2452	-3580
Cav1	-2380	-3313
Plin3	-383	-3274

Click HERE to show all gene set members

All member genes

	LPS	OVA
Abhd5	-5682	-6275
Cav1	-2380	-3313
Fabp3	2207	-3518
Fabp5	-4419	-7170
Fabp7	-7382	-8241
Gpd2	-6603	-5396
Lipe	6933	2661
Mgll	4080	743
Plin3	-383	-3274
Ppp1ca	537	-3982
Ppp1cb	-8086	-7047
Ppp1cc	-2452	-3580
Prkaca	4407	5641
Prkacb	-7699	-7589

---

---

G BETA GAMMA SIGNALLING THROUGH CDC42

G BETA GAMMA SIGNALLING THROUGH CDC42

metric	value
setSize	18
pMANOVA	0.00962
p.adjustMANOVA	0.0416
s.dist	0.509
s.LPS	-0.301
s.OVA	-0.411
p.LPS	0.027
p.OVA	0.00255

Top 20 genes

Gene	LPS	OVA
Cdc42	-8072	-8187
Pak1	-6861	-8065
Gng12	-6644	-7142
Gng11	-5717	-8201
Gng10	-5616	-7169
Gnb4	-5892	-5361
Gng2	-7333	-4079
Gnb1	-5182	-5068
Gng5	-4101	-4343
Gng4	-2566	-2443
Gng3	-1007	-3994

Click HERE to show all gene set members

All member genes

	LPS	OVA
Arhgef6	3312	6044
Cdc42	-8072	-8187
Gnb1	-5182	-5068
Gnb2	6733	2146
Gnb4	-5892	-5361
Gnb5	1596	-445
Gng10	-5616	-7169
Gng11	-5717	-8201
Gng12	-6644	-7142
Gng13	874	-2150
Gng2	-7333	-4079
Gng3	-1007	-3994
Gng4	-2566	-2443
Gng5	-4101	-4343
Gng7	4482	2541
Gng8	846	908
Gngt2	30	-5315
Pak1	-6861	-8065

---

---

SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM

metric	value
setSize	109
pMANOVA	3.67e-31
p.adjustMANOVA	4.29e-29
s.dist	0.5
s.LPS	-0.135
s.OVA	-0.482
p.LPS	0.0153
p.OVA	3.61e-18

Top 20 genes

Gene	LPS	OVA
Rps18	-8130	-8305
Hnmt	-8095	-8039
Rps7	-7425	-8293
Rpl22l1	-7570	-8090
Eef1e1	-7294	-8294
Dars	-8019	-7413
Rpl35a	-7115	-8275
Rpl30	-6706	-8242
Rpl5	-6827	-7989
Rars	-6882	-7616
Rps2	-6487	-7717
Aimp1	-5656	-7518
Rpl3	-5307	-7372
Rpl27a	-4837	-7755
Rps3a1	-4714	-7196
Rpl15	-4648	-7094
Rpl29	-4310	-7539
Rpl24	-4859	-6682
Rps4x	-4466	-7050
Rps24	-4142	-7540

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ahcy	-4027	-7536
Aimp1	-5656	-7518
Aimp2	3815	-453
Cbs	1897	-2586
Cth	-3046	2428
Dars	-8019	-7413
Eef1e1	-7294	-8294
Eefsec	5343	1255
Eprs	-4406	-5000
Fau	2620	-3235
Gnmt	3597	5987
Gsr	-3581	-2658
Hnmt	-8095	-8039
Iars	4556	5479
Inmt	1351	-448
Kars	1436	-3364
Lars	-3742	-1207
Mars1	7941	6648
Papss1	144	-2774
Papss2	-3569	-4734
Pstk	-1355	-5566
Qars	5733	6253
Rars	-6882	-7616
Rpl10	2424	507
Rpl10a	991	-4758
Rpl11	-2505	-6265
Rpl12	3956	941
Rpl13	3375	-1929
Rpl13a	-2547	-6497
Rpl14	-3851	-6213
Rpl15	-4648	-7094
Rpl17	-3127	-6495
Rpl18	2994	-2908
Rpl18a	304	-5493
Rpl19	1011	-3676
Rpl21	1147	-4966
Rpl22	-4097	-6119
Rpl22l1	-7570	-8090
Rpl23	-2534	-5395
Rpl23a	-428	-5507
Rpl24	-4859	-6682
Rpl26	-4005	-7477
Rpl27	-285	-4949
Rpl27a	-4837	-7755
Rpl28	1738	-3911
Rpl29	-4310	-7539
Rpl3	-5307	-7372
Rpl30	-6706	-8242
Rpl31	108	-5140
Rpl32	552	-3620
Rpl34	2271	-2980
Rpl35	1205	-1839
Rpl35a	-7115	-8275
Rpl36	4587	-161
Rpl36a	-3373	-7573
Rpl36al	1237	-4874
Rpl37	3844	143
Rpl37a	2789	-3065
Rpl38	4255	1284
Rpl39	520	-2708
Rpl4	-3201	-6174
Rpl5	-6827	-7989
Rpl6	-4396	-6936
Rpl7	-3881	-6564
Rpl7a	1582	-4322
Rpl8	2864	-2597
Rpl9	-3187	-6715
Rplp0	-2961	-8015
Rplp1	2427	-2664
Rplp2	3909	-422
Rps10	1539	-4274
Rps11	539	-4477
Rps12	3920	-1797
Rps13	-3077	-6001
Rps14	-1149	-6092
Rps15	2979	-2178
Rps15a	-263	-3337
Rps16	-1649	-5137
Rps17	355	-3810
Rps18	-8130	-8305
Rps19	-304	-4694
Rps2	-6487	-7717
Rps20	789	-5035
Rps21	1676	-1411
Rps23	-2519	-6491
Rps24	-4142	-7540
Rps25	-1835	-5671
Rps26	726	-3827
Rps27	256	-3603
Rps27a	-4151	-6446
Rps27l	-3637	-5926
Rps28	4824	2397
Rps29	5536	3958
Rps3	-3359	-6570
Rps3a1	-4714	-7196
Rps4x	-4466	-7050
Rps5	2415	-3011
Rps6	-2212	-6729
Rps7	-7425	-8293
Rps8	-2385	-6533
Rps9	-1060	-5311
Rpsa	1252	-4509
Sars	-1743	-7138
Scly	5491	1965
Secisbp2	7285	8246
Sephs2	-219	-4631
Sepsecs	-4025	2295
Txnrd1	-41	3618
Uba52	1246	-3922

---

---

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

metric	value
setSize	20
pMANOVA	0.0158
p.adjustMANOVA	0.0612
s.dist	0.5
s.LPS	-0.345
s.OVA	-0.362
p.LPS	0.00751
p.OVA	0.00513

Top 20 genes

Gene	LPS	OVA
Hsd17b12	-7216	-8232
Acsl3	-8046	-6960
Hacd3	-7137	-7805
Acsl4	-8070	-6627
Elovl7	-7004	-7626
Elovl4	-7421	-6669
Elovl5	-6073	-7530
Acsl5	-5501	-7661
Elovl2	-5378	-6264
Hacd1	-5120	-5801
Hacd2	-3819	-1709
Acsl6	-2677	-2174
Hacd4	-3325	-436

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acsbg1	7061	-21
Acsf3	484	-418
Acsl1	-2927	1741
Acsl3	-8046	-6960
Acsl4	-8070	-6627
Acsl5	-5501	-7661
Acsl6	-2677	-2174
Elovl1	7393	4421
Elovl2	-5378	-6264
Elovl4	-7421	-6669
Elovl5	-6073	-7530
Elovl6	-938	3030
Elovl7	-7004	-7626
Hacd1	-5120	-5801
Hacd2	-3819	-1709
Hacd3	-7137	-7805
Hacd4	-3325	-436
Hsd17b12	-7216	-8232
Slc27a3	8426	7903
Tecr	4188	101

---

---

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

metric	value
setSize	11
pMANOVA	0.00678
p.adjustMANOVA	0.0317
s.dist	0.498
s.LPS	-0.196
s.OVA	-0.458
p.LPS	0.26
p.OVA	0.00853

Top 20 genes

Gene	LPS	OVA
Hsp90b1	-8033	-8274
Tlr3	-7845	-8182
Ctsl	-6093	-7913
Ctss	-5275	-7892
Ctsb	-2008	-6487
Lgmn	-1645	-5751
Tlr7	-1297	-1917

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cnpy3	6272	1830
Ctsb	-2008	-6487
Ctsk	736	-1448
Ctsl	-6093	-7913
Ctss	-5275	-7892
Hsp90b1	-8033	-8274
Lgmn	-1645	-5751
Tlr3	-7845	-8182
Tlr7	-1297	-1917
Tlr9	6137	2331
Unc93b1	3603	2466

---

---

SIGNALING BY LEPTIN

SIGNALING BY LEPTIN

metric	value
setSize	10
pMANOVA	0.0367
p.adjustMANOVA	0.121
s.dist	0.498
s.LPS	0.247
s.OVA	0.433
p.LPS	0.177
p.OVA	0.0178

Top 20 genes

Gene	LPS	OVA
Sh2b1	8630	8132
Ptpn11	6123	6036
Stat3	5605	6413
Irs1	2144	4443
Stat5a	3244	2936
Irs2	2423	3364
Stat5b	1313	4813

Click HERE to show all gene set members

All member genes

	LPS	OVA
Irs1	2144	4443
Irs2	2423	3364
Jak2	-3206	4310
Lepr	-6178	-2457
Ptpn11	6123	6036
Sh2b1	8630	8132
Socs3	3062	-676
Stat3	5605	6413
Stat5a	3244	2936
Stat5b	1313	4813

---

---

NCAM1 INTERACTIONS

NCAM1 INTERACTIONS

metric	value
setSize	40
pMANOVA	0.000124
p.adjustMANOVA	0.00106
s.dist	0.498
s.LPS	0.312
s.OVA	0.388
p.LPS	0.000629
p.OVA	2.22e-05

Top 20 genes

Gene	LPS	OVA
Cacna1h	8563	8467
Agrn	7350	7835
Cacna1d	6141	8256
Col9a3	6333	7595
Cacna1i	6624	7188
Cacnb1	6553	6668
Cacna1c	5583	7192
Ncan	5753	6785
Col4a2	6176	6207
Cacnb3	7266	5273
Cacna1g	5761	5813
Col4a1	5565	5825
Cntn2	5749	5516
Col4a3	3771	7472
Col2a1	4614	5090
Col4a5	4191	5165
Gfra4	5402	3976
Col6a3	3129	5432
Gfra1	3200	4827
Gfra2	2108	5584

Click HERE to show all gene set members

All member genes

	LPS	OVA
Agrn	7350	7835
Artn	2802	-529
Cacna1c	5583	7192
Cacna1d	6141	8256
Cacna1g	5761	5813
Cacna1h	8563	8467
Cacna1i	6624	7188
Cacna1s	1888	2965
Cacnb1	6553	6668
Cacnb2	64	4065
Cacnb3	7266	5273
Cacnb4	-7846	-6578
Cntn2	5749	5516
Col2a1	4614	5090
Col3a1	-3803	-6704
Col4a1	5565	5825
Col4a2	6176	6207
Col4a3	3771	7472
Col4a4	2341	4532
Col4a5	4191	5165
Col5a1	424	3729
Col5a2	1371	2650
Col5a3	1099	2890
Col6a1	1086	3260
Col6a2	-506	2525
Col6a3	3129	5432
Col6a5	1486	1978
Col6a6	-567	4355
Col9a1	-1525	-1142
Col9a2	2078	-1024
Col9a3	6333	7595
Gfra1	3200	4827
Gfra2	2108	5584
Gfra4	5402	3976
Ncam1	3044	3569
Ncan	5753	6785
Nrtn	7211	-2203
Prnp	-3183	-6388
St8sia2	4364	1346
St8sia4	-7160	-5585

---

---

REPRESSION OF WNT TARGET GENES

REPRESSION OF WNT TARGET GENES

metric	value
setSize	14
pMANOVA	0.0409
p.adjustMANOVA	0.131
s.dist	0.495
s.LPS	0.39
s.OVA	0.305
p.LPS	0.0116
p.OVA	0.0479

Top 20 genes

Gene	LPS	OVA
Axin2	7319	7119
Tle1	7197	7082
Myc	5722	7516
Ctbp2	6780	6218
Tle2	6414	5747
Tle3	4785	7093
Tcf7l1	5057	1304
Ctbp1	6289	876
Hdac1	1578	396

Click HERE to show all gene set members

All member genes

	LPS	OVA
Axin2	7319	7119
Ctbp1	6289	876
Ctbp2	6780	6218
Hdac1	1578	396
Lef1	-1884	-238
Myc	5722	7516
Tcf7	-221	-254
Tcf7l1	5057	1304
Tcf7l2	-2870	-3804
Tle1	7197	7082
Tle2	6414	5747
Tle3	4785	7093
Tle4	-2468	-1216
Tle5	5516	-581

---

---

INTERLEUKIN 12 SIGNALING

INTERLEUKIN 12 SIGNALING

metric	value
setSize	37
pMANOVA	4.64e-06
p.adjustMANOVA	6.23e-05
s.dist	0.494
s.LPS	-0.241
s.OVA	-0.431
p.LPS	0.0111
p.OVA	5.7e-06

Top 20 genes

Gene	LPS	OVA
Cdc42	-8072	-8187
Tcp1	-7623	-8207
Rap1b	-7859	-7820
Hnrnpdl	-6738	-7873
Pdcd4	-7509	-6937
Hnrnpa2b1	-7014	-7327
Rala	-6902	-7384
Hspa9	-6630	-7411
Ppia	-4873	-7794
Capza1	-6506	-5748
Pak2	-6917	-4954
Mtap	-3884	-6769
Rplp0	-2961	-8015
Sod2	-6103	-3718
Psme2	-3439	-6535
Hnrnpf	-4212	-4629
Snrpa1	-3603	-5177
Lcp1	-2724	-5799
Jak1	-3163	-2000
Pitpna	-2644	-1681

Click HERE to show all gene set members

All member genes

	LPS	OVA
Aip	4000	-2593
Anxa2	5321	502
Arf1	2085	-556
Bola2	4079	-8
Capza1	-6506	-5748
Cdc42	-8072	-8187
Cfl1	4853	-2988
Cnn2	51	-4976
Gsto1	-779	-5498
Hnrnpa2b1	-7014	-7327
Hnrnpdl	-6738	-7873
Hnrnpf	-4212	-4629
Hspa9	-6630	-7411
Il12a	-1770	-352
Il12rb1	4184	5155
Jak1	-3163	-2000
Jak2	-3206	4310
Lcp1	-2724	-5799
Lmnb1	2923	1452
Mif	7925	3959
Msn	-491	-1247
Mtap	-3884	-6769
P4hb	-598	-4335
Pak2	-6917	-4954
Pdcd4	-7509	-6937
Pitpna	-2644	-1681
Ppia	-4873	-7794
Psme2	-3439	-6535
Rala	-6902	-7384
Rap1b	-7859	-7820
Rplp0	-2961	-8015
Snrpa1	-3603	-5177
Sod1	3519	-3184
Sod2	-6103	-3718
Taldo1	3561	-3776
Tcp1	-7623	-8207
Tyk2	7875	7995

---

---

CELLULAR HEXOSE TRANSPORT

CELLULAR HEXOSE TRANSPORT

metric	value
setSize	11
pMANOVA	0.0918
p.adjustMANOVA	0.231
s.dist	0.493
s.LPS	0.38
s.OVA	0.313
p.LPS	0.0289
p.OVA	0.0721

Top 20 genes

Gene	LPS	OVA
Slc2a6	8637	7974
Slc2a8	8399	8055
Slc2a1	6638	5084
Slc50a1	5949	4696
Slc2a10	3462	1059
Slc2a4	1952	706
Slc2a9	176	3850

Click HERE to show all gene set members

All member genes

	LPS	OVA
Mfsd4b1	2643	-2956
Slc2a1	6638	5084
Slc2a10	3462	1059
Slc2a12	-1998	170
Slc2a3	-960	2430
Slc2a4	1952	706
Slc2a6	8637	7974
Slc2a8	8399	8055
Slc2a9	176	3850
Slc45a3	2928	-1070
Slc50a1	5949	4696

---

---

NOTCH HLH TRANSCRIPTION PATHWAY

NOTCH HLH TRANSCRIPTION PATHWAY

metric	value
setSize	28
pMANOVA	0.00102
p.adjustMANOVA	0.00686
s.dist	0.489
s.LPS	0.283
s.OVA	0.399
p.LPS	0.00961
p.OVA	0.00026

Top 20 genes

Gene	LPS	OVA
Ncor2	8539	8430
Crebbp	7827	8435
Notch1	8134	8108
Notch3	8253	7807
Hdac6	8153	7363
Notch4	7740	7742
Hdac7	7581	7714
Notch2	6888	8155
Hdac5	7994	6650
Hdac4	4562	7043
Kat2a	6234	4505
Hdac11	5663	4415
Hdac10	4839	4744
Maml3	5015	4293
Maml1	4890	3645
Mamld1	2228	7789
Hdac3	3531	1874
Maml2	1073	3309
Hdac8	3198	896
Hdac1	1578	396

Click HERE to show all gene set members

All member genes

	LPS	OVA
Crebbp	7827	8435
Hdac1	1578	396
Hdac10	4839	4744
Hdac11	5663	4415
Hdac2	-7492	-7511
Hdac3	3531	1874
Hdac4	4562	7043
Hdac5	7994	6650
Hdac6	8153	7363
Hdac7	7581	7714
Hdac8	3198	896
Hdac9	-6276	-3777
Kat2a	6234	4505
Kat2b	-5129	-319
Maml1	4890	3645
Maml2	1073	3309
Maml3	5015	4293
Mamld1	2228	7789
Ncor1	-57	2989
Ncor2	8539	8430
Notch1	8134	8108
Notch2	6888	8155
Notch3	8253	7807
Notch4	7740	7742
Rbpj	-1272	2623
Snw1	-7194	-7749
Tbl1x	-6207	-2518
Tbl1xr1	-7052	-665

---

---

NEGATIVE REGULATION OF NOTCH4 SIGNALING

NEGATIVE REGULATION OF NOTCH4 SIGNALING

metric	value
setSize	54
pMANOVA	2.29e-10
p.adjustMANOVA	8.12e-09
s.dist	0.488
s.LPS	-0.201
s.OVA	-0.445
p.LPS	0.0106
p.OVA	1.6e-08

Top 20 genes

Gene	LPS	OVA
Skp1	-8036	-8257
Fbxw7	-7812	-8168
Psmc6	-7882	-7901
Psmd12	-7584	-8163
Psmc1	-7198	-8230
Psma3	-7260	-7957
Psma6	-6854	-8032
Psmd14	-7258	-7504
Psmd10	-6563	-7183
Ywhaz	-7536	-6155
Psmd1	-6197	-6999
Psmd6	-5728	-7382
Psmb7	-5546	-7292
Psma5	-5426	-7068
Psma4	-5360	-7106
Psma2	-4918	-7326
Psma1	-5113	-6647
Psmb1	-4485	-7541
Rbx1	-4537	-6743
Psmc2	-4304	-6762

Click HERE to show all gene set members

All member genes

	LPS	OVA
Akt1	6930	5737
Cul1	-5866	-2757
Fbxw7	-7812	-8168
Notch4	7740	7742
Psma1	-5113	-6647
Psma2	-4918	-7326
Psma3	-7260	-7957
Psma4	-5360	-7106
Psma5	-5426	-7068
Psma6	-6854	-8032
Psma7	480	-5353
Psmb1	-4485	-7541
Psmb10	2000	-2567
Psmb2	2335	1229
Psmb3	5158	-859
Psmb4	1500	-4091
Psmb5	7077	4120
Psmb6	2730	-1694
Psmb7	-5546	-7292
Psmb8	-3413	-6746
Psmb9	-4243	-3009
Psmc1	-7198	-8230
Psmc2	-4304	-6762
Psmc3	4535	-3114
Psmc4	7152	2298
Psmc5	-127	-4586
Psmc6	-7882	-7901
Psmd1	-6197	-6999
Psmd10	-6563	-7183
Psmd11	-2032	653
Psmd12	-7584	-8163
Psmd13	2543	-1418
Psmd14	-7258	-7504
Psmd2	2200	-102
Psmd3	8278	7098
Psmd4	5879	1498
Psmd5	-2929	-3209
Psmd6	-5728	-7382
Psmd7	-3757	-6629
Psmd8	-81	-6372
Psmd9	3730	179
Psme1	-2092	-3119
Psme2	-3439	-6535
Psme3	-2906	-3339
Psmf1	116	387
Rbx1	-4537	-6743
Rps27a	-4151	-6446
Sem1	942	-3238
Skp1	-8036	-8257
Tacc3	-336	2303
Uba52	1246	-3922
Ubb	5592	-1688
Ubc	4950	173
Ywhaz	-7536	-6155

---

---

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

metric	value
setSize	47
pMANOVA	3.15e-09
p.adjustMANOVA	9.44e-08
s.dist	0.487
s.LPS	-0.198
s.OVA	-0.445
p.LPS	0.0188
p.OVA	1.31e-07

Top 20 genes

Gene	LPS	OVA
Psmc6	-7882	-7901
Psmd12	-7584	-8163
Psmc1	-7198	-8230
Psma3	-7260	-7957
Psma6	-6854	-8032
Psmd14	-7258	-7504
Psmd10	-6563	-7183
Psmd1	-6197	-6999
Psmd6	-5728	-7382
Psmb7	-5546	-7292
Psma5	-5426	-7068
Psma4	-5360	-7106
Psma2	-4918	-7326
Psma1	-5113	-6647
Psmb1	-4485	-7541
Psmc2	-4304	-6762
Mrc1	-4806	-5867
Psmd7	-3757	-6629
Psmb8	-3413	-6746
Psme2	-3439	-6535

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fcgr1	-983	-3836
Mrc1	-4806	-5867
Mrc2	5289	445
Psma1	-5113	-6647
Psma2	-4918	-7326
Psma3	-7260	-7957
Psma4	-5360	-7106
Psma5	-5426	-7068
Psma6	-6854	-8032
Psma7	480	-5353
Psmb1	-4485	-7541
Psmb10	2000	-2567
Psmb11	1940	2685
Psmb2	2335	1229
Psmb3	5158	-859
Psmb4	1500	-4091
Psmb5	7077	4120
Psmb6	2730	-1694
Psmb7	-5546	-7292
Psmb8	-3413	-6746
Psmb9	-4243	-3009
Psmc1	-7198	-8230
Psmc2	-4304	-6762
Psmc3	4535	-3114
Psmc4	7152	2298
Psmc5	-127	-4586
Psmc6	-7882	-7901
Psmd1	-6197	-6999
Psmd10	-6563	-7183
Psmd11	-2032	653
Psmd12	-7584	-8163
Psmd13	2543	-1418
Psmd14	-7258	-7504
Psmd2	2200	-102
Psmd3	8278	7098
Psmd4	5879	1498
Psmd5	-2929	-3209
Psmd6	-5728	-7382
Psmd7	-3757	-6629
Psmd8	-81	-6372
Psmd9	3730	179
Psme1	-2092	-3119
Psme2	-3439	-6535
Psme3	-2906	-3339
Psme4	-2014	3540
Psmf1	116	387
Sem1	942	-3238

---

---

NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

metric	value
setSize	20
pMANOVA	0.0179
p.adjustMANOVA	0.067
s.dist	0.486
s.LPS	0.321
s.OVA	0.364
p.LPS	0.0129
p.OVA	0.00483

Top 20 genes

Gene	LPS	OVA
Crebbp	7827	8435
Notch1	8134	8108
Notch4	7740	7742
Notch2	6888	8155
Smad3	5238	6348
Flt4	5278	5704
Kat2a	6234	4505
Ep300	3578	7132
Maml3	5015	4293
Maml1	4890	3645
Mamld1	2228	7789
Hes5	5386	2999
Maml2	1073	3309

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acta2	914	-2362
Crebbp	7827	8435
Ep300	3578	7132
Flt4	5278	5704
Hes1	4432	-5464
Hes5	5386	2999
Hey1	-422	-1082
Hey2	-2038	-757
Kat2a	6234	4505
Kat2b	-5129	-319
Maml1	4890	3645
Maml2	1073	3309
Maml3	5015	4293
Mamld1	2228	7789
Notch1	8134	8108
Notch2	6888	8155
Notch4	7740	7742
Rbpj	-1272	2623
Smad3	5238	6348
Snw1	-7194	-7749

---

---

DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS

DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS

metric	value
setSize	59
pMANOVA	3.44e-10
p.adjustMANOVA	1.09e-08
s.dist	0.482
s.LPS	-0.211
s.OVA	-0.433
p.LPS	0.00503
p.OVA	8.89e-09

Top 20 genes

Gene	LPS	OVA
Erlec1	-8034	-8067
Psmc6	-7882	-7901
Psmd12	-7584	-8163
Derl2	-7839	-7796
Psmc1	-7198	-8230
Psma3	-7260	-7957
Psma6	-6854	-8032
Psmd14	-7258	-7504
Psmd10	-6563	-7183
Psmd1	-6197	-6999
Psmd6	-5728	-7382
Psmb7	-5546	-7292
Psma5	-5426	-7068
Psma4	-5360	-7106
Psma2	-4918	-7326
Psma1	-5113	-6647
Psmb1	-4485	-7541
Psmc2	-4304	-6762
Rps27a	-4151	-6446
Psmd7	-3757	-6629

Click HERE to show all gene set members

All member genes

	LPS	OVA
Derl1	-431	-4411
Derl2	-7839	-7796
Derl3	55	-1345
Erlec1	-8034	-8067
Erlin1	-4637	-2554
Erlin2	-4093	3021
Os9	849	-1749
Psma1	-5113	-6647
Psma2	-4918	-7326
Psma3	-7260	-7957
Psma4	-5360	-7106
Psma5	-5426	-7068
Psma6	-6854	-8032
Psma7	480	-5353
Psmb1	-4485	-7541
Psmb10	2000	-2567
Psmb11	1940	2685
Psmb2	2335	1229
Psmb3	5158	-859
Psmb4	1500	-4091
Psmb5	7077	4120
Psmb6	2730	-1694
Psmb7	-5546	-7292
Psmb8	-3413	-6746
Psmb9	-4243	-3009
Psmc1	-7198	-8230
Psmc2	-4304	-6762
Psmc3	4535	-3114
Psmc4	7152	2298
Psmc5	-127	-4586
Psmc6	-7882	-7901
Psmd1	-6197	-6999
Psmd10	-6563	-7183
Psmd11	-2032	653
Psmd12	-7584	-8163
Psmd13	2543	-1418
Psmd14	-7258	-7504
Psmd2	2200	-102
Psmd3	8278	7098
Psmd4	5879	1498
Psmd5	-2929	-3209
Psmd6	-5728	-7382
Psmd7	-3757	-6629
Psmd8	-81	-6372
Psmd9	3730	179
Psme1	-2092	-3119
Psme2	-3439	-6535
Psme3	-2906	-3339
Psme4	-2014	3540
Psmf1	116	387
Rnf185	-1846	-1753
Rnf5	-579	-6438
Rps27a	-4151	-6446
Sel1l	-2301	2600
Sem1	942	-3238
Uba52	1246	-3922
Ubb	5592	-1688
Ubc	4950	173
Vcp	-2647	-6321

---

---

SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL

SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL

metric	value
setSize	26
pMANOVA	0.00436
p.adjustMANOVA	0.0221
s.dist	0.481
s.LPS	0.303
s.OVA	0.374
p.LPS	0.00754
p.OVA	0.000977

Top 20 genes

Gene	LPS	OVA
Itpk1	8641	8300
Inppl1	8333	8288
Plcg1	8017	8348
Plch2	7949	8172
Inpp5j	8116	7767
Itpka	7005	5760
Plcb2	5675	6881
Inpp5b	4951	7117
Pld4	6550	4996
Plcb3	7249	4119
Plcg2	5526	5215
Inpp5d	5815	4944
Plcd1	5473	4380
Itpkc	5836	4043
Itpkb	4540	3899
Plcd3	5040	1798
Plce1	152	4795

Click HERE to show all gene set members

All member genes

	LPS	OVA
Calm1	-7789	-8217
Inpp5b	4951	7117
Inpp5d	5815	4944
Inpp5j	8116	7767
Inppl1	8333	8288
Itpk1	8641	8300
Itpka	7005	5760
Itpkb	4540	3899
Itpkc	5836	4043
Ocrl	-1271	5322
Plcb1	-5291	-2015
Plcb2	5675	6881
Plcb3	7249	4119
Plcb4	-4294	-4607
Plcd1	5473	4380
Plcd3	5040	1798
Plcd4	-152	1704
Plce1	152	4795
Plcg1	8017	8348
Plcg2	5526	5215
Plch1	-2998	183
Plch2	7949	8172
Plcz1	-859	-3927
Pld4	6550	4996
Pten	-7959	-6623
Synj1	-1883	3388

---

---

RUNX3 REGULATES NOTCH SIGNALING

RUNX3 REGULATES NOTCH SIGNALING

metric	value
setSize	13
pMANOVA	0.059
p.adjustMANOVA	0.169
s.dist	0.48
s.LPS	0.293
s.OVA	0.38
p.LPS	0.0671
p.OVA	0.0177

Top 20 genes

Gene	LPS	OVA
Crebbp	7827	8435
Notch1	8134	8108
Jag1	5368	6447
Kat2a	6234	4505
Ep300	3578	7132
Maml3	5015	4293
Maml1	4890	3645
Mamld1	2228	7789
Maml2	1073	3309

Click HERE to show all gene set members

All member genes

	LPS	OVA
Crebbp	7827	8435
Ep300	3578	7132
Hes1	4432	-5464
Jag1	5368	6447
Kat2a	6234	4505
Kat2b	-5129	-319
Maml1	4890	3645
Maml2	1073	3309
Maml3	5015	4293
Mamld1	2228	7789
Notch1	8134	8108
Rbpj	-1272	2623
Snw1	-7194	-7749

---

---

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES

metric	value
setSize	62
pMANOVA	6.79e-06
p.adjustMANOVA	8.63e-05
s.dist	0.48
s.LPS	0.326
s.OVA	0.352
p.LPS	8.95e-06
p.OVA	1.68e-06

Top 20 genes

Gene	LPS	OVA
Plod3	8446	7666
Plod1	7400	7469
Adamts14	7086	7743
P3h3	7063	7200
P3h1	7139	6948
Colgalt1	7165	6893
Col9a3	6333	7595
P3h2	6121	7361
P4ha2	6062	7204
Serpinh1	8128	5151
Col26a1	5772	6836
Col4a2	6176	6207
Col27a1	5687	5951
Col4a1	5565	5825
Col4a3	3771	7472
Col11a2	5305	4516
Col2a1	4614	5090
Bmp1	5174	4539
Col4a5	4191	5165
Col18a1	5856	3619

Click HERE to show all gene set members

All member genes

	LPS	OVA
Adamts14	7086	7743
Adamts2	1976	4524
Adamts3	2750	6702
Bmp1	5174	4539
Col11a1	3150	2892
Col11a2	5305	4516
Col12a1	4186	3636
Col13a1	5010	3865
Col14a1	-1843	666
Col15a1	2121	348
Col16a1	3676	4684
Col18a1	5856	3619
Col19a1	1918	5916
Col1a1	6151	1839
Col1a2	2456	-2665
Col20a1	3696	1920
Col22a1	2218	3719
Col23a1	-918	-1768
Col24a1	-1357	-5794
Col25a1	-1584	3154
Col26a1	5772	6836
Col27a1	5687	5951
Col2a1	4614	5090
Col3a1	-3803	-6704
Col4a1	5565	5825
Col4a2	6176	6207
Col4a3	3771	7472
Col4a4	2341	4532
Col4a5	4191	5165
Col5a1	424	3729
Col5a2	1371	2650
Col5a3	1099	2890
Col6a1	1086	3260
Col6a2	-506	2525
Col6a3	3129	5432
Col6a5	1486	1978
Col6a6	-567	4355
Col7a1	2963	3166
Col8a1	952	1336
Col8a2	4069	5007
Col9a1	-1525	-1142
Col9a2	2078	-1024
Col9a3	6333	7595
Colgalt1	7165	6893
Colgalt2	-1838	-1163
Crtap	4056	2337
P3h1	7139	6948
P3h2	6121	7361
P3h3	7063	7200
P4ha1	-1031	-2398
P4ha2	6062	7204
P4ha3	3959	2435
P4hb	-598	-4335
Pcolce	7297	66
Pcolce2	-93	2776
Plod1	7400	7469
Plod2	-5502	-5513
Plod3	8446	7666
Ppib	4667	1591
Serpinh1	8128	5151
Tll1	-2464	-1902
Tll2	4692	2626

---

---

INTERLEUKIN 37 SIGNALING

INTERLEUKIN 37 SIGNALING

metric	value
setSize	17
pMANOVA	0.019
p.adjustMANOVA	0.0703
s.dist	0.477
s.LPS	0.277
s.OVA	0.388
p.LPS	0.0482
p.OVA	0.00556

Top 20 genes

Gene	LPS	OVA
Ptpn23	8192	8189
Ptpn5	8552	7780
Ptpn13	7288	7449
Ptpn14	6069	7357
Ptpn11	6123	6036
Stat3	5605	6413
Smad3	5238	6348
Sigirr	6325	3178
Il18bp	3968	4612
Ptpn9	2868	5230
Ptpn6	2595	2579
Ptpn18	1220	2169

Click HERE to show all gene set members

All member genes

	LPS	OVA
Casp1	-5810	-5382
Il18bp	3968	4612
Ptpn11	6123	6036
Ptpn12	-1235	3669
Ptpn13	7288	7449
Ptpn14	6069	7357
Ptpn18	1220	2169
Ptpn2	-5831	-6002
Ptpn23	8192	8189
Ptpn4	-6582	-5037
Ptpn5	8552	7780
Ptpn6	2595	2579
Ptpn9	2868	5230
Sigirr	6325	3178
Smad3	5238	6348
Stat3	5605	6413
Tbk1	-947	2506

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report