Mitch Report

date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
	x
0610009B22Rik	-3.3814425
0610009E02Rik	-0.3557659
0610009L18Rik	-0.8507498
0610010K14Rik	1.2510787
0610012G03Rik	3.9729326
0610030E20Rik	0.1581737

Here are some metrics about the input data profile:

Profiling data metrics
	Profile metrics
num_genesets	1604
num_genes_in_profile	16911
duplicated_genes_present	0
num_profile_genes_in_sets	8289
num_profile_genes_not_in_sets	8622

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene set metrics
	Gene sets metrics
num_genesets	1604
num_genesets_excluded	434
num_genesets_included	1170

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.

set	setSize	pANOVA	s.dist	p.adjustANOVA
COHESIN LOADING ONTO CHROMATIN	10	3.53e-03	-0.533	0.05990
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	1.40e-03	-0.533	0.03760
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.18e-03	-0.520	0.03710
TERMINATION OF O GLYCAN BIOSYNTHESIS	11	3.28e-03	0.512	0.05900
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	2.65e-04	0.511	0.01740
CROSSLINKING OF COLLAGEN FIBRILS	15	9.38e-04	0.493	0.03710
PROCESSING AND ACTIVATION OF SUMO	10	8.22e-03	-0.483	0.10100
APOPTOSIS INDUCED DNA FRAGMENTATION	10	8.22e-03	-0.483	0.10100
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.06e-02	0.467	0.11100
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	3.73e-03	0.465	0.06230
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	4.42e-03	0.456	0.06710
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	6.28e-03	-0.456	0.08640
CD28 DEPENDENT VAV1 PATHWAY	11	1.14e-02	-0.441	0.11200
ACTIVATION OF SMO	16	2.80e-03	0.432	0.05560
MITOTIC TELOPHASE CYTOKINESIS	13	1.12e-02	-0.406	0.11200
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.73e-04	-0.403	0.01450
MET ACTIVATES RAP1 AND RAC1	11	2.26e-02	-0.397	0.16500
REPRESSION OF WNT TARGET GENES	14	1.17e-02	0.389	0.11400
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	2.67e-02	-0.386	0.18100
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	3.53e-02	-0.384	0.21900
CELLULAR HEXOSE TRANSPORT	11	2.92e-02	0.380	0.19300
ACTIVATION OF RAC1	13	1.82e-02	-0.378	0.14400
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	4.32e-03	0.369	0.06710
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	1.81e-02	0.365	0.14400
SYNAPTIC ADHESION LIKE MOLECULES	21	4.09e-03	0.362	0.06550
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	35	2.82e-04	0.355	0.01740
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	1.87e-02	0.351	0.14700
NRAGE SIGNALS DEATH THROUGH JNK	55	8.30e-06	0.347	0.00203
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	7.28e-03	-0.347	0.09800
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	2.32e-03	0.345	0.04970
MATURATION OF NUCLEOPROTEIN	10	5.99e-02	-0.344	0.28800
EARLY PHASE OF HIV LIFE CYCLE	13	3.38e-02	-0.340	0.21400
SIGNALING BY FGFR4 IN DISEASE	10	6.56e-02	-0.336	0.30600
PRE NOTCH PROCESSING IN GOLGI	18	1.39e-02	0.335	0.12800
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	6.99e-02	-0.331	0.31000
E2F MEDIATED REGULATION OF DNA REPLICATION	19	1.37e-02	-0.327	0.12800
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	62	9.27e-06	0.326	0.00203
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	5.23e-02	0.324	0.27800
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	35	9.83e-04	0.322	0.03710
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	7.59e-03	0.322	0.09860
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	1.30e-02	0.321	0.12100
CRMPS IN SEMA3A SIGNALING	16	2.66e-02	0.320	0.18100
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	1.72e-02	-0.316	0.14300
NCAM1 INTERACTIONS	40	6.39e-04	0.312	0.03120
PEXOPHAGY	11	8.02e-02	0.305	0.33300
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	13	5.75e-02	0.304	0.28600
INSULIN PROCESSING	24	9.90e-03	-0.304	0.10900
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	8.23e-02	0.303	0.33700
G BETA GAMMA SIGNALLING THROUGH CDC42	18	2.63e-02	-0.303	0.18100
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	5.91e-02	0.302	0.28800

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
COHESIN LOADING ONTO CHROMATIN	10	3.53e-03	-5.33e-01	0.059900
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	1.40e-03	-5.33e-01	0.037600
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.18e-03	-5.20e-01	0.037100
TERMINATION OF O GLYCAN BIOSYNTHESIS	11	3.28e-03	5.12e-01	0.059000
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	2.65e-04	5.11e-01	0.017400
CROSSLINKING OF COLLAGEN FIBRILS	15	9.38e-04	4.93e-01	0.037100
PROCESSING AND ACTIVATION OF SUMO	10	8.22e-03	-4.83e-01	0.101000
APOPTOSIS INDUCED DNA FRAGMENTATION	10	8.22e-03	-4.83e-01	0.101000
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.06e-02	4.67e-01	0.111000
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	3.73e-03	4.65e-01	0.062300
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	4.42e-03	4.56e-01	0.067100
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	12	6.28e-03	-4.56e-01	0.086400
CD28 DEPENDENT VAV1 PATHWAY	11	1.14e-02	-4.41e-01	0.112000
ACTIVATION OF SMO	16	2.80e-03	4.32e-01	0.055600
MITOTIC TELOPHASE CYTOKINESIS	13	1.12e-02	-4.06e-01	0.112000
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.73e-04	-4.03e-01	0.014500
MET ACTIVATES RAP1 AND RAC1	11	2.26e-02	-3.97e-01	0.165000
REPRESSION OF WNT TARGET GENES	14	1.17e-02	3.89e-01	0.114000
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	2.67e-02	-3.86e-01	0.181000
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	3.53e-02	-3.84e-01	0.219000
CELLULAR HEXOSE TRANSPORT	11	2.92e-02	3.80e-01	0.193000
ACTIVATION OF RAC1	13	1.82e-02	-3.78e-01	0.144000
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	4.32e-03	3.69e-01	0.067100
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	1.81e-02	3.65e-01	0.144000
SYNAPTIC ADHESION LIKE MOLECULES	21	4.09e-03	3.62e-01	0.065500
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	35	2.82e-04	3.55e-01	0.017400
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	1.87e-02	3.51e-01	0.147000
NRAGE SIGNALS DEATH THROUGH JNK	55	8.30e-06	3.47e-01	0.002030
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	7.28e-03	-3.47e-01	0.098000
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	2.32e-03	3.45e-01	0.049700
MATURATION OF NUCLEOPROTEIN	10	5.99e-02	-3.44e-01	0.288000
EARLY PHASE OF HIV LIFE CYCLE	13	3.38e-02	-3.40e-01	0.214000
SIGNALING BY FGFR4 IN DISEASE	10	6.56e-02	-3.36e-01	0.306000
PRE NOTCH PROCESSING IN GOLGI	18	1.39e-02	3.35e-01	0.128000
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	6.99e-02	-3.31e-01	0.310000
E2F MEDIATED REGULATION OF DNA REPLICATION	19	1.37e-02	-3.27e-01	0.128000
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	62	9.27e-06	3.26e-01	0.002030
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	5.23e-02	3.24e-01	0.278000
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	35	9.83e-04	3.22e-01	0.037100
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	7.59e-03	3.22e-01	0.098600
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	1.30e-02	3.21e-01	0.121000
CRMPS IN SEMA3A SIGNALING	16	2.66e-02	3.20e-01	0.181000
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	1.72e-02	-3.16e-01	0.143000
NCAM1 INTERACTIONS	40	6.39e-04	3.12e-01	0.031200
PEXOPHAGY	11	8.02e-02	3.05e-01	0.333000
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	13	5.75e-02	3.04e-01	0.286000
INSULIN PROCESSING	24	9.90e-03	-3.04e-01	0.109000
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	8.23e-02	3.03e-01	0.337000
G BETA GAMMA SIGNALLING THROUGH CDC42	18	2.63e-02	-3.03e-01	0.181000
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	5.91e-02	3.02e-01	0.288000
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	26	7.63e-03	3.02e-01	0.098600
MET ACTIVATES RAS SIGNALING	10	9.87e-02	-3.02e-01	0.372000
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	8.35e-02	-3.01e-01	0.339000
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	7.41e-02	-2.98e-01	0.314000
PROTEIN UBIQUITINATION	69	2.04e-05	-2.97e-01	0.002390
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	4.31e-03	-2.96e-01	0.067100
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	2.23e-02	2.95e-01	0.164000
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	6.69e-02	2.94e-01	0.306000
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	1.08e-01	2.93e-01	0.383000
RUNX3 REGULATES NOTCH SIGNALING	13	6.73e-02	2.93e-01	0.306000
RHO GTPASES ACTIVATE IQGAPS	23	1.50e-02	2.93e-01	0.135000
GAP JUNCTION ASSEMBLY	22	1.76e-02	2.92e-01	0.144000
LGI ADAM INTERACTIONS	14	6.09e-02	2.89e-01	0.290000
RETROGRADE NEUROTROPHIN SIGNALLING	13	7.10e-02	2.89e-01	0.311000
COLLAGEN FORMATION	78	1.04e-05	2.89e-01	0.002030
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	5.35e-02	-2.88e-01	0.278000
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	5.37e-02	2.88e-01	0.278000
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	23	1.70e-02	-2.87e-01	0.143000
SIGNALING BY FLT3 FUSION PROTEINS	18	3.54e-02	-2.86e-01	0.219000
RMTS METHYLATE HISTONE ARGININES	43	1.18e-03	2.86e-01	0.037100
NOTCH HLH TRANSCRIPTION PATHWAY	28	9.69e-03	2.82e-01	0.109000
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	4.61e-02	2.79e-01	0.262000
RHOBTB1 GTPASE CYCLE	23	2.09e-02	-2.78e-01	0.157000
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	13	8.29e-02	2.78e-01	0.338000
INTERLEUKIN 37 SIGNALING	17	4.85e-02	2.76e-01	0.267000
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	3.26e-02	2.76e-01	0.210000
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	54	5.04e-04	2.74e-01	0.029500
RECYCLING PATHWAY OF L1	40	2.87e-03	2.72e-01	0.055900
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	4.56e-02	2.72e-01	0.262000
KINESINS	48	1.11e-03	2.72e-01	0.037100
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	9.00e-02	2.72e-01	0.354000
PROTEIN METHYLATION	17	5.42e-02	-2.70e-01	0.278000
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	50	9.79e-04	-2.70e-01	0.037100
PHASE 2 PLATEAU PHASE	13	9.31e-02	2.69e-01	0.356000
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	9.32e-02	2.69e-01	0.356000
IRE1ALPHA ACTIVATES CHAPERONES	49	1.21e-03	2.67e-01	0.037100
COLLAGEN CHAIN TRIMERIZATION	39	4.03e-03	2.66e-01	0.065500
CARNITINE METABOLISM	14	8.92e-02	2.62e-01	0.353000
METHYLATION	11	1.35e-01	-2.60e-01	0.432000
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	7.75e-03	-2.60e-01	0.098600
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	8.13e-02	2.60e-01	0.335000
TRIGLYCERIDE CATABOLISM	14	9.32e-02	-2.59e-01	0.356000
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	5.86e-02	2.58e-01	0.287000
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	1.11e-01	2.55e-01	0.387000
GLUCONEOGENESIS	27	2.22e-02	2.54e-01	0.164000
GAP JUNCTION TRAFFICKING AND REGULATION	34	1.07e-02	2.53e-01	0.111000
REGULATION OF TLR BY ENDOGENOUS LIGAND	12	1.30e-01	-2.52e-01	0.422000
ANCHORING FIBRIL FORMATION	14	1.03e-01	2.52e-01	0.376000
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	5.22e-02	-2.51e-01	0.278000
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	73	2.29e-04	2.49e-01	0.017400
VLDLR INTERNALISATION AND DEGRADATION	12	1.35e-01	2.49e-01	0.432000
PEPTIDE HORMONE METABOLISM	58	1.06e-03	-2.49e-01	0.037100
HSF1 DEPENDENT TRANSACTIVATION	35	1.11e-02	2.48e-01	0.112000
SIGNALING BY LEPTIN	10	1.78e-01	2.46e-01	0.483000
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	10	1.80e-01	2.45e-01	0.484000
PYRUVATE METABOLISM	27	2.86e-02	-2.43e-01	0.191000
INTERLEUKIN 12 SIGNALING	37	1.07e-02	-2.43e-01	0.111000
SIGNALING BY BMP	24	4.10e-02	-2.41e-01	0.243000
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.49e-01	-2.41e-01	0.452000
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	1.68e-01	-2.40e-01	0.475000
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	51	3.09e-03	2.40e-01	0.058000
BIOTIN TRANSPORT AND METABOLISM	11	1.71e-01	2.38e-01	0.475000
RHOBTB3 ATPASE CYCLE	10	1.96e-01	-2.36e-01	0.505000
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	4.51e-02	-2.36e-01	0.261000
BRANCHED CHAIN AMINO ACID CATABOLISM	21	6.09e-02	-2.36e-01	0.290000
NCAM SIGNALING FOR NEURITE OUT GROWTH	60	1.68e-03	2.35e-01	0.042700
SHC MEDIATED CASCADE FGFR4	11	1.79e-01	-2.34e-01	0.484000
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	8.61e-02	2.34e-01	0.344000
REGULATION OF BETA CELL DEVELOPMENT	24	4.78e-02	2.33e-01	0.266000
KERATAN SULFATE BIOSYNTHESIS	23	5.32e-02	2.33e-01	0.278000
REGULATION OF IFNG SIGNALING	13	1.48e-01	-2.32e-01	0.452000
ELEVATION OF CYTOSOLIC CA2 LEVELS	15	1.21e-01	2.31e-01	0.410000
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	4.23e-02	2.30e-01	0.249000
CDC42 GTPASE CYCLE	152	1.01e-06	2.30e-01	0.000589
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	1.23e-01	2.30e-01	0.414000
THE PHOTOTRANSDUCTION CASCADE	21	6.86e-02	-2.30e-01	0.308000
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	1.88e-01	2.29e-01	0.493000
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	37	1.59e-02	2.29e-01	0.139000
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	2.49e-02	2.29e-01	0.174000
P75NTR SIGNALS VIA NF KB	16	1.13e-01	2.29e-01	0.391000
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	2.11e-01	2.29e-01	0.523000
CGMP EFFECTS	15	1.25e-01	-2.29e-01	0.415000
INTERACTION BETWEEN L1 AND ANKYRINS	27	4.01e-02	2.28e-01	0.242000
P75 NTR RECEPTOR MEDIATED SIGNALLING	94	1.40e-04	2.27e-01	0.012600
AGGREPHAGY	34	2.21e-02	2.27e-01	0.164000
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	4.60e-02	2.26e-01	0.262000
DARPP 32 EVENTS	23	6.05e-02	-2.26e-01	0.290000
TIE2 SIGNALING	17	1.07e-01	-2.26e-01	0.383000
PHOSPHORYLATION OF THE APC C	17	1.09e-01	-2.25e-01	0.383000
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	2.20e-01	-2.24e-01	0.534000
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	2.00e-01	2.23e-01	0.511000
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	2.00e-01	-2.23e-01	0.511000
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	7.12e-02	2.22e-01	0.311000
METABOLISM OF POLYAMINES	58	3.47e-03	-2.22e-01	0.059900
DEADENYLATION OF MRNA	25	5.50e-02	-2.22e-01	0.279000
PI 3K CASCADE FGFR4	11	2.03e-01	-2.22e-01	0.514000
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	1.25e-01	-2.21e-01	0.415000
DISEASES OF GLYCOSYLATION	127	1.76e-05	2.21e-01	0.002280
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	1.54e-01	2.20e-01	0.460000
SIGNALLING TO RAS	18	1.07e-01	2.20e-01	0.382000
IRAK4 DEFICIENCY TLR2 4	13	1.71e-01	-2.19e-01	0.475000
SEMA4D IN SEMAPHORIN SIGNALING	24	6.56e-02	2.17e-01	0.306000
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	1.75e-02	-2.17e-01	0.144000
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	1.03e-01	-2.16e-01	0.376000
G ALPHA 12 13 SIGNALLING EVENTS	74	1.37e-03	2.15e-01	0.037600
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	1.06e-01	-2.14e-01	0.382000
SIGNALING BY PDGFR IN DISEASE	20	9.82e-02	-2.14e-01	0.372000
ECM PROTEOGLYCANS	66	2.75e-03	2.13e-01	0.055500
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	4.71e-03	-2.13e-01	0.070700
REGULATION OF BACH1 ACTIVITY	11	2.22e-01	-2.13e-01	0.535000
KERATAN SULFATE KERATIN METABOLISM	29	4.82e-02	2.12e-01	0.266000
OLFACTORY SIGNALING PATHWAY	30	4.47e-02	-2.12e-01	0.260000
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	1.56e-01	-2.12e-01	0.461000
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	1.21e-01	2.11e-01	0.410000
RAB GERANYLGERANYLATION	59	5.05e-03	-2.11e-01	0.074800
CHONDROITIN SULFATE BIOSYNTHESIS	19	1.11e-01	2.11e-01	0.387000
LAMININ INTERACTIONS	28	5.35e-02	2.11e-01	0.278000
INTERLEUKIN 10 SIGNALING	20	1.03e-01	-2.11e-01	0.376000
INTERLEUKIN 20 FAMILY SIGNALING	13	1.89e-01	2.11e-01	0.494000
INITIAL TRIGGERING OF COMPLEMENT	11	2.28e-01	2.10e-01	0.546000
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	1.23e-01	-2.10e-01	0.414000
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	9.65e-02	2.10e-01	0.368000
PURINE CATABOLISM	16	1.49e-01	-2.09e-01	0.452000
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	5.60e-03	-2.09e-01	0.080900
RHOBTB GTPASE CYCLE	35	3.28e-02	-2.08e-01	0.210000
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	1.63e-01	-2.08e-01	0.468000
RHOBTB2 GTPASE CYCLE	23	8.47e-02	-2.08e-01	0.342000
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	8.55e-02	-2.07e-01	0.343000
SYNTHESIS OF PE	13	1.99e-01	2.06e-01	0.511000
ORC1 REMOVAL FROM CHROMATIN	68	3.52e-03	-2.05e-01	0.059900
ELASTIC FIBRE FORMATION	36	3.43e-02	2.04e-01	0.216000
DEGRADATION OF THE EXTRACELLULAR MATRIX	107	2.73e-04	2.04e-01	0.017400
ANTIGEN PROCESSING CROSS PRESENTATION	95	6.38e-04	-2.03e-01	0.031200
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	1.01e-02	-2.02e-01	0.110000
PYROPTOSIS	21	1.09e-01	-2.02e-01	0.384000
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	87	1.18e-03	-2.01e-01	0.037100
SUMOYLATION OF INTRACELLULAR RECEPTORS	25	8.17e-02	-2.01e-01	0.336000
S PHASE	155	1.60e-05	-2.01e-01	0.002280
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	12	2.29e-01	-2.01e-01	0.548000
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	47	1.79e-02	-2.00e-01	0.144000
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	70	3.90e-03	-2.00e-01	0.064300
INTERFERON ALPHA BETA SIGNALING	52	1.29e-02	-1.99e-01	0.121000
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	1.68e-01	-1.99e-01	0.475000
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	1.44e-01	1.99e-01	0.444000
PLATELET AGGREGATION PLUG FORMATION	32	5.15e-02	1.99e-01	0.278000
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	79	2.34e-03	-1.98e-01	0.049700
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	1.00e-01	1.98e-01	0.375000
PRE NOTCH EXPRESSION AND PROCESSING	64	6.20e-03	1.98e-01	0.086300
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.57e-01	-1.97e-01	0.580000
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	1.27e-01	-1.97e-01	0.417000
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	20	1.28e-01	-1.97e-01	0.418000
O LINKED GLYCOSYLATION	89	1.40e-03	1.96e-01	0.037600
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	11	2.61e-01	-1.96e-01	0.585000
INTERLEUKIN 12 FAMILY SIGNALING	44	2.47e-02	-1.96e-01	0.174000
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	49	1.82e-02	1.95e-01	0.144000
FATTY ACYL COA BIOSYNTHESIS	32	5.76e-02	-1.94e-01	0.286000
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	3.70e-02	1.93e-01	0.227000
PROCESSING OF SMDT1	16	1.82e-01	-1.93e-01	0.486000
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	46	2.40e-02	1.92e-01	0.171000
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	1.08e-02	-1.92e-01	0.111000
CHOLESTEROL BIOSYNTHESIS	24	1.04e-01	-1.92e-01	0.378000
GLYCOGEN SYNTHESIS	14	2.14e-01	-1.92e-01	0.527000
EXTRACELLULAR MATRIX ORGANIZATION	241	3.14e-07	1.92e-01	0.000367
INTEGRIN SIGNALING	24	1.05e-01	1.91e-01	0.381000
SIGNALING BY NOTCH2	33	5.81e-02	1.91e-01	0.287000
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	32	6.24e-02	-1.90e-01	0.296000
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	3.08e-03	-1.90e-01	0.058000
HYALURONAN METABOLISM	15	2.03e-01	1.90e-01	0.514000
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	31	6.79e-02	1.90e-01	0.308000
GLUTAMATE AND GLUTAMINE METABOLISM	13	2.39e-01	1.89e-01	0.561000
SIGNALING BY FLT3 ITD AND TKD MUTANTS	15	2.06e-01	-1.89e-01	0.519000
DNA DAMAGE BYPASS	47	2.56e-02	-1.88e-01	0.177000
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	1.36e-01	1.88e-01	0.434000
HDACS DEACETYLATE HISTONES	46	2.77e-02	1.88e-01	0.186000
COLLAGEN DEGRADATION	51	2.05e-02	1.88e-01	0.157000
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	1.20e-01	1.87e-01	0.409000
STABILIZATION OF P53	55	1.68e-02	-1.87e-01	0.143000
TRANSLESION SYNTHESIS BY POLH	19	1.60e-01	-1.86e-01	0.465000
ASPARTATE AND ASPARAGINE METABOLISM	10	3.07e-01	-1.86e-01	0.646000
FRS MEDIATED FGFR4 SIGNALING	13	2.45e-01	-1.86e-01	0.566000
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	2.12e-01	1.86e-01	0.525000
SIGNALING BY FGFR1 IN DISEASE	32	6.92e-02	-1.86e-01	0.309000
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	9.82e-03	-1.85e-01	0.109000
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	2.00e-01	1.85e-01	0.511000
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	31	7.45e-02	1.85e-01	0.314000
TRP CHANNELS	18	1.76e-01	1.84e-01	0.480000
SIGNALING BY KIT IN DISEASE	20	1.55e-01	-1.83e-01	0.461000
SIGNALING BY ERBB2 ECD MUTANTS	16	2.04e-01	-1.83e-01	0.515000
INTERFERON GAMMA SIGNALING	73	6.82e-03	-1.83e-01	0.092800
G2 M DNA DAMAGE CHECKPOINT	65	1.07e-02	-1.83e-01	0.111000
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	7.32e-02	1.83e-01	0.312000
INOSITOL PHOSPHATE METABOLISM	47	3.04e-02	1.83e-01	0.198000
P75NTR RECRUITS SIGNALLING COMPLEXES	13	2.54e-01	1.83e-01	0.579000
RET SIGNALING	36	5.85e-02	1.82e-01	0.287000
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	30	8.50e-02	-1.82e-01	0.342000
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	26	1.10e-01	1.81e-01	0.385000
GP1B IX V ACTIVATION SIGNALLING	10	3.22e-01	1.81e-01	0.660000
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	120	6.40e-04	1.81e-01	0.031200
RHOB GTPASE CYCLE	67	1.09e-02	1.80e-01	0.111000
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	12	2.82e-01	1.79e-01	0.617000
SIGNALING BY HIPPO	20	1.65e-01	-1.79e-01	0.472000
TRANSLESION SYNTHESIS BY POLK	17	2.01e-01	-1.79e-01	0.512000
MITOTIC SPINDLE CHECKPOINT	96	2.45e-03	-1.79e-01	0.051300
DISEASES OF METABOLISM	201	1.26e-05	1.79e-01	0.002110
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	30	9.01e-02	-1.79e-01	0.354000
ORGANIC CATION ANION ZWITTERION TRANSPORT	10	3.29e-01	1.78e-01	0.667000
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	7.19e-02	-1.78e-01	0.312000
MITOCHONDRIAL TRNA AMINOACYLATION	21	1.62e-01	1.76e-01	0.467000
FGFR1 MUTANT RECEPTOR ACTIVATION	25	1.27e-01	-1.76e-01	0.417000
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	1.01e-01	-1.76e-01	0.376000
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	64	1.52e-02	-1.76e-01	0.136000
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	3.15e-01	-1.75e-01	0.653000
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	1.03e-01	1.75e-01	0.376000
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	15	2.41e-01	1.75e-01	0.561000
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	50	3.25e-02	1.75e-01	0.210000
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.89e-03	-1.75e-01	0.043300
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	70	1.19e-02	-1.74e-01	0.114000
DISEASES OF CARBOHYDRATE METABOLISM	29	1.07e-01	1.73e-01	0.383000
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	1.02e-01	1.73e-01	0.376000
DNA METHYLATION	20	1.82e-01	1.73e-01	0.486000
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	3.45e-01	1.72e-01	0.678000
APOPTOTIC EXECUTION PHASE	45	4.57e-02	-1.72e-01	0.262000
MET ACTIVATES PTK2 SIGNALING	29	1.10e-01	1.72e-01	0.384000
GABA RECEPTOR ACTIVATION	53	3.07e-02	-1.72e-01	0.200000
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	3.25e-01	1.72e-01	0.664000
NEUREXINS AND NEUROLIGINS	54	2.93e-02	1.72e-01	0.193000
PHASE 4 RESTING MEMBRANE POTENTIAL	14	2.67e-01	1.71e-01	0.596000
DNA REPLICATION PRE INITIATION	81	7.73e-03	-1.71e-01	0.098600
CELL CYCLE CHECKPOINTS	243	4.44e-06	-1.71e-01	0.001730
PI 3K CASCADE FGFR2	16	2.37e-01	-1.71e-01	0.560000
SYNTHESIS OF PA	29	1.12e-01	1.71e-01	0.388000
DNA REPLICATION	123	1.16e-03	-1.70e-01	0.037100
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	2.40e-01	-1.70e-01	0.561000
HIV TRANSCRIPTION INITIATION	45	4.97e-02	-1.69e-01	0.271000
EUKARYOTIC TRANSLATION INITIATION	114	1.84e-03	-1.69e-01	0.043300
DEATH RECEPTOR SIGNALLING	133	7.93e-04	1.69e-01	0.034400
SUMOYLATION OF DNA METHYLATION PROTEINS	16	2.45e-01	1.68e-01	0.566000
G PROTEIN ACTIVATION	22	1.73e-01	-1.68e-01	0.476000
REGULATED NECROSIS	46	4.94e-02	-1.68e-01	0.270000
BETA CATENIN PHOSPHORYLATION CASCADE	16	2.47e-01	-1.67e-01	0.568000
NEPHRIN FAMILY INTERACTIONS	22	1.75e-01	1.67e-01	0.479000
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	1.67e-01	1.66e-01	0.475000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	24	1.60e-01	-1.66e-01	0.465000
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	6.68e-02	1.65e-01	0.306000
DEGRADATION OF GLI1 BY THE PROTEASOME	58	2.94e-02	-1.65e-01	0.193000
SIGNALING BY NOTCH3	48	4.80e-02	1.65e-01	0.266000
GAB1 SIGNALOSOME	13	3.03e-01	1.65e-01	0.644000
G2 M CHECKPOINTS	135	9.61e-04	-1.65e-01	0.037100
FORMATION OF THE CORNIFIED ENVELOPE	29	1.25e-01	1.65e-01	0.415000
KERATINIZATION	29	1.25e-01	1.65e-01	0.415000
EFFECTS OF PIP2 HYDROLYSIS	27	1.39e-01	1.65e-01	0.437000
G1 S DNA DAMAGE CHECKPOINTS	66	2.09e-02	-1.65e-01	0.157000
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	1.72e-01	1.64e-01	0.476000
P38MAPK EVENTS	12	3.32e-01	1.62e-01	0.667000
INTERLEUKIN 6 SIGNALING	10	3.75e-01	1.62e-01	0.694000
METABOLISM OF FOLATE AND PTERINES	15	2.78e-01	1.62e-01	0.612000
FORMATION OF INCISION COMPLEX IN GG NER	43	6.72e-02	-1.61e-01	0.306000
MTORC1 MEDIATED SIGNALLING	24	1.72e-01	-1.61e-01	0.476000
ATTENUATION PHASE	25	1.64e-01	1.61e-01	0.470000
DEGRADATION OF AXIN	54	4.15e-02	-1.60e-01	0.245000
COPI MEDIATED ANTEROGRADE TRANSPORT	90	8.72e-03	1.60e-01	0.103000
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	1.84e-01	-1.60e-01	0.488000
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	2.28e-01	1.60e-01	0.546000
CS DS DEGRADATION	14	3.01e-01	1.60e-01	0.644000
FC EPSILON RECEPTOR FCERI SIGNALING	124	2.17e-03	-1.60e-01	0.047900
TRANSCRIPTIONAL REGULATION BY E2F6	34	1.08e-01	-1.59e-01	0.383000
MUCOPOLYSACCHARIDOSES	11	3.61e-01	1.59e-01	0.694000
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	2.19e-01	-1.59e-01	0.532000
FCERI MEDIATED NF KB ACTIVATION	77	1.60e-02	-1.59e-01	0.139000
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	3.42e-01	1.58e-01	0.676000
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	2.33e-01	-1.58e-01	0.555000
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	9.22e-02	1.58e-01	0.356000
INTERFERON SIGNALING	161	5.56e-04	-1.58e-01	0.031000
KILLING MECHANISMS	10	3.89e-01	1.57e-01	0.707000
SIGNALING BY THE B CELL RECEPTOR BCR	104	5.72e-03	-1.57e-01	0.081600
TBC RABGAPS	43	7.56e-02	1.57e-01	0.317000
DEGRADATION OF DVL	56	4.29e-02	-1.56e-01	0.251000
HS GAG DEGRADATION	21	2.18e-01	1.55e-01	0.532000
AMINE LIGAND BINDING RECEPTORS	29	1.49e-01	1.55e-01	0.452000
DERMATAN SULFATE BIOSYNTHESIS	11	3.75e-01	1.55e-01	0.694000
GLUTATHIONE SYNTHESIS AND RECYCLING	11	3.76e-01	1.54e-01	0.694000
ER QUALITY CONTROL COMPARTMENT ERQC	21	2.22e-01	-1.54e-01	0.535000
INTERLEUKIN 6 FAMILY SIGNALING	20	2.34e-01	1.54e-01	0.555000
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	1.93e-01	-1.54e-01	0.501000
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	73	2.36e-02	-1.53e-01	0.169000
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	1.07e-02	-1.52e-01	0.111000
PLATELET ADHESION TO EXPOSED COLLAGEN	11	3.81e-01	-1.52e-01	0.698000
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	3.42e-01	1.52e-01	0.676000
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	31	1.43e-01	1.52e-01	0.443000
MITOTIC G1 PHASE AND G1 S TRANSITION	142	1.82e-03	-1.52e-01	0.043300
SHC MEDIATED CASCADE FGFR1	14	3.28e-01	-1.51e-01	0.666000
FRS MEDIATED FGFR2 SIGNALING	18	2.68e-01	-1.51e-01	0.597000
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	3.47e-01	1.51e-01	0.679000
REGULATION OF PTEN STABILITY AND ACTIVITY	67	3.31e-02	-1.51e-01	0.211000
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	1.72e-02	-1.51e-01	0.143000
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	2.57e-01	-1.50e-01	0.580000
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	54	5.62e-02	-1.50e-01	0.283000
HEDGEHOG LIGAND BIOGENESIS	62	4.08e-02	-1.50e-01	0.243000
COMPLEX I BIOGENESIS	56	5.26e-02	-1.50e-01	0.278000
NON INTEGRIN MEMBRANE ECM INTERACTIONS	56	5.30e-02	1.50e-01	0.278000
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	3.00e-01	-1.50e-01	0.644000
LYSOSPHINGOLIPID AND LPA RECEPTORS	11	3.91e-01	-1.50e-01	0.707000
CONSTITUTIVE SIGNALING BY EGFRVIII	15	3.16e-01	-1.49e-01	0.654000
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	1.72e-01	-1.49e-01	0.476000
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	1.70e-02	1.49e-01	0.143000
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	107	8.09e-03	1.48e-01	0.101000
PLASMA LIPOPROTEIN CLEARANCE	26	1.92e-01	1.48e-01	0.501000
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	1.69e-01	1.47e-01	0.475000
GRB2 EVENTS IN ERBB2 SIGNALING	14	3.40e-01	-1.47e-01	0.676000
REGULATION OF EXPRESSION OF SLITS AND ROBOS	161	1.27e-03	-1.47e-01	0.037600
NEGATIVE REGULATION OF FLT3	15	3.26e-01	1.46e-01	0.666000
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	85	2.07e-02	-1.45e-01	0.157000
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	2.08e-02	1.45e-01	0.157000
REDUCTION OF CYTOSOLIC CA LEVELS	12	3.85e-01	-1.45e-01	0.703000
RORA ACTIVATES GENE EXPRESSION	18	2.88e-01	1.45e-01	0.627000
FORMATION OF APOPTOSOME	10	4.28e-01	-1.45e-01	0.737000
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	17	3.03e-01	1.44e-01	0.644000
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	2.53e-01	-1.44e-01	0.578000
METABOLISM OF FAT SOLUBLE VITAMINS	32	1.60e-01	1.44e-01	0.465000
SEPARATION OF SISTER CHROMATIDS	165	1.57e-03	-1.43e-01	0.040800
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	1.33e-01	1.43e-01	0.430000
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	7.29e-02	-1.42e-01	0.312000
CALNEXIN CALRETICULIN CYCLE	26	2.09e-01	-1.42e-01	0.522000
TERMINATION OF TRANSLESION DNA SYNTHESIS	31	1.70e-01	-1.42e-01	0.475000
HEME BIOSYNTHESIS	13	3.74e-01	1.42e-01	0.694000
BLOOD GROUP SYSTEMS BIOSYNTHESIS	12	3.93e-01	-1.42e-01	0.708000
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	1.40e-01	-1.42e-01	0.439000
SHC1 EVENTS IN ERBB4 SIGNALING	12	3.95e-01	-1.42e-01	0.709000
CD28 CO STIMULATION	30	1.80e-01	-1.42e-01	0.484000
PI 3K CASCADE FGFR1	14	3.60e-01	-1.41e-01	0.694000
LONG TERM POTENTIATION	23	2.41e-01	1.41e-01	0.561000
CELLULAR RESPONSE TO HYPOXIA	72	3.85e-02	-1.41e-01	0.233000
REGULATION OF RAS BY GAPS	67	4.63e-02	-1.41e-01	0.262000
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	85	2.51e-02	1.41e-01	0.175000
RAC1 GTPASE CYCLE	176	1.40e-03	1.40e-01	0.037600
PYRIMIDINE SALVAGE	10	4.44e-01	1.40e-01	0.750000
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	3.69e-01	-1.39e-01	0.694000
MICRORNA MIRNA BIOGENESIS	24	2.40e-01	1.39e-01	0.561000
SIGNALING BY NOTCH1	75	3.84e-02	1.38e-01	0.233000
RIPK1 MEDIATED REGULATED NECROSIS	25	2.32e-01	-1.38e-01	0.553000
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	3.11e-01	-1.38e-01	0.650000
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	38	1.42e-01	-1.38e-01	0.441000
FGFR2 LIGAND BINDING AND ACTIVATION	11	4.29e-01	-1.38e-01	0.738000
SENSORY PROCESSING OF SOUND	61	6.30e-02	1.38e-01	0.297000
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	2.55e-01	-1.37e-01	0.579000
MITOTIC METAPHASE AND ANAPHASE	206	7.01e-04	-1.37e-01	0.031500
SODIUM CALCIUM EXCHANGERS	10	4.53e-01	-1.37e-01	0.757000
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	3.93e-01	-1.37e-01	0.708000
HIV ELONGATION ARREST AND RECOVERY	32	1.82e-01	1.36e-01	0.486000
SEMAPHORIN INTERACTIONS	64	5.95e-02	1.36e-01	0.288000
PHOSPHOLIPID METABOLISM	185	1.41e-03	1.36e-01	0.037600
SELENOAMINO ACID METABOLISM	109	1.41e-02	-1.36e-01	0.128000
FANCONI ANEMIA PATHWAY	36	1.58e-01	1.36e-01	0.465000
ONCOGENE INDUCED SENESCENCE	32	1.84e-01	1.36e-01	0.488000
TCR SIGNALING	102	1.83e-02	-1.35e-01	0.144000
ADHERENS JUNCTIONS INTERACTIONS	29	2.08e-01	-1.35e-01	0.522000
VOLTAGE GATED POTASSIUM CHANNELS	40	1.39e-01	1.35e-01	0.437000
NONSENSE MEDIATED DECAY NMD	109	1.53e-02	-1.35e-01	0.136000
PROLONGED ERK ACTIVATION EVENTS	13	4.02e-01	-1.34e-01	0.716000
G PROTEIN BETA GAMMA SIGNALLING	30	2.05e-01	-1.34e-01	0.517000
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	3.70e-01	-1.34e-01	0.694000
CHROMATIN MODIFYING ENZYMES	218	6.84e-04	1.34e-01	0.031500
MEIOTIC RECOMBINATION	38	1.54e-01	-1.34e-01	0.460000
CLEC7A DECTIN 1 SIGNALING	95	2.45e-02	-1.34e-01	0.174000
C TYPE LECTIN RECEPTORS CLRS	114	1.41e-02	-1.33e-01	0.128000
GOLGI ASSOCIATED VESICLE BIOGENESIS	54	9.32e-02	-1.32e-01	0.356000
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	3.94e-01	1.32e-01	0.708000
PROCESSING OF INTRONLESS PRE MRNAS	19	3.21e-01	-1.32e-01	0.658000
DAP12 INTERACTIONS	29	2.20e-01	-1.32e-01	0.534000
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	60	7.83e-02	-1.31e-01	0.327000
GLYCOSAMINOGLYCAN METABOLISM	114	1.56e-02	1.31e-01	0.137000
RHOC GTPASE CYCLE	73	5.26e-02	1.31e-01	0.278000
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	1.80e-01	-1.31e-01	0.484000
SHC MEDIATED CASCADE FGFR3	13	4.14e-01	-1.31e-01	0.726000
CA2 PATHWAY	56	9.03e-02	-1.31e-01	0.354000
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	71	5.69e-02	-1.31e-01	0.286000
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	2.78e-01	1.31e-01	0.612000
HOST INTERACTIONS OF HIV FACTORS	124	1.21e-02	-1.31e-01	0.115000
EXTRA NUCLEAR ESTROGEN SIGNALING	65	6.87e-02	-1.31e-01	0.308000
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	3.13e-01	1.30e-01	0.652000
EUKARYOTIC TRANSLATION ELONGATION	87	3.69e-02	-1.29e-01	0.227000
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	23	2.83e-01	-1.29e-01	0.618000
DSCAM INTERACTIONS	10	4.83e-01	1.28e-01	0.781000
HCMV EARLY EVENTS	80	4.77e-02	1.28e-01	0.266000
SPRY REGULATION OF FGF SIGNALING	16	3.75e-01	1.28e-01	0.694000
JOSEPHIN DOMAIN DUBS	11	4.63e-01	1.28e-01	0.766000
STIMULI SENSING CHANNELS	74	5.76e-02	1.28e-01	0.286000
L1CAM INTERACTIONS	107	2.27e-02	1.28e-01	0.165000
RHOA GTPASE CYCLE	141	9.15e-03	1.27e-01	0.106000
COSTIMULATION BY THE CD28 FAMILY	49	1.24e-01	-1.27e-01	0.415000
ASSEMBLY OF THE HIV VIRION	16	3.79e-01	1.27e-01	0.698000
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	1.61e-01	1.26e-01	0.467000
INFLUENZA INFECTION	145	8.79e-03	-1.26e-01	0.103000
PLASMA LIPOPROTEIN REMODELING	15	3.99e-01	1.26e-01	0.711000
ER TO GOLGI ANTEROGRADE TRANSPORT	139	1.05e-02	1.26e-01	0.111000
METABOLISM OF PORPHYRINS	19	3.44e-01	1.26e-01	0.677000
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	2.98e-01	1.25e-01	0.640000
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	4.94e-01	1.25e-01	0.783000
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	4.19e-01	1.25e-01	0.727000
GLUCOSE METABOLISM	80	5.48e-02	1.24e-01	0.279000
G ALPHA S SIGNALLING EVENTS	98	3.50e-02	1.23e-01	0.219000
METABOLISM OF COFACTORS	18	3.66e-01	-1.23e-01	0.694000
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	22	3.18e-01	-1.23e-01	0.656000
ACYL CHAIN REMODELLING OF PS	14	4.27e-01	1.23e-01	0.737000
EPH EPHRIN MEDIATED REPULSION OF CELLS	51	1.30e-01	1.23e-01	0.422000
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	3.20e-01	-1.23e-01	0.658000
FRS MEDIATED FGFR1 SIGNALING	16	3.96e-01	-1.23e-01	0.709000
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	3.33e-01	-1.22e-01	0.667000
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	3.70e-01	-1.22e-01	0.694000
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	80	5.92e-02	-1.22e-01	0.288000
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	5.05e-01	-1.22e-01	0.787000
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	1.06e-01	1.22e-01	0.382000
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	4.86e-01	-1.21e-01	0.782000
TRAFFICKING OF AMPA RECEPTORS	31	2.43e-01	1.21e-01	0.565000
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	3.05e-01	1.21e-01	0.644000
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	44	1.66e-01	1.21e-01	0.473000
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	4.18e-01	1.21e-01	0.727000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	18	3.76e-01	-1.21e-01	0.694000
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	4.89e-01	1.21e-01	0.782000
MISMATCH REPAIR	14	4.35e-01	-1.20e-01	0.743000
PI 3K CASCADE FGFR3	13	4.52e-01	-1.20e-01	0.757000
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	32	2.39e-01	1.20e-01	0.561000
ENOS ACTIVATION	11	4.91e-01	-1.20e-01	0.782000
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	77	6.87e-02	1.20e-01	0.308000
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	4.72e-01	1.20e-01	0.772000
IRON UPTAKE AND TRANSPORT	51	1.41e-01	-1.19e-01	0.441000
O LINKED GLYCOSYLATION OF MUCINS	42	1.82e-01	1.19e-01	0.486000
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	4.76e-01	1.19e-01	0.776000
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	3.97e-01	1.19e-01	0.709000
OXIDATIVE STRESS INDUCED SENESCENCE	78	7.02e-02	1.19e-01	0.310000
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	3.71e-01	-1.19e-01	0.694000
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	1.44e-01	-1.18e-01	0.444000
CRISTAE FORMATION	31	2.56e-01	-1.18e-01	0.580000
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	4.63e-01	1.18e-01	0.766000
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	4.15e-01	1.18e-01	0.727000
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	4.65e-01	1.17e-01	0.766000
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	5.02e-01	1.17e-01	0.787000
OTHER SEMAPHORIN INTERACTIONS	19	3.81e-01	1.16e-01	0.698000
MEIOSIS	64	1.09e-01	-1.16e-01	0.383000
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	14	4.53e-01	-1.16e-01	0.757000
SIGNALING BY ERBB2 IN CANCER	24	3.27e-01	-1.16e-01	0.666000
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	10	5.27e-01	1.16e-01	0.805000
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	168	9.86e-03	1.16e-01	0.109000
REGULATION OF TNFR1 SIGNALING	34	2.44e-01	1.15e-01	0.566000
PEROXISOMAL LIPID METABOLISM	26	3.10e-01	-1.15e-01	0.649000
HIV INFECTION	220	3.36e-03	-1.15e-01	0.059600
NETRIN 1 SIGNALING	48	1.70e-01	1.14e-01	0.475000
HDMS DEMETHYLATE HISTONES	27	3.04e-01	1.14e-01	0.644000
SIGNALING BY ERBB4	56	1.39e-01	-1.14e-01	0.437000
FCERI MEDIATED MAPK ACTIVATION	28	2.95e-01	-1.14e-01	0.638000
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	9.23e-02	-1.14e-01	0.356000
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	45	1.87e-01	-1.14e-01	0.493000
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.16e-01	-1.14e-01	0.654000
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	1.69e-01	-1.14e-01	0.475000
DISEASES OF DNA REPAIR	11	5.16e-01	-1.13e-01	0.795000
METABOLISM OF CARBOHYDRATES	257	1.94e-03	1.12e-01	0.043800
DEADENYLATION DEPENDENT MRNA DECAY	55	1.49e-01	-1.12e-01	0.452000
INFLAMMASOMES	19	3.97e-01	-1.12e-01	0.709000
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	13	4.83e-01	1.12e-01	0.781000
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	16	4.39e-01	1.12e-01	0.744000
RESPIRATORY ELECTRON TRANSPORT	102	5.13e-02	-1.12e-01	0.278000
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	5.22e-01	-1.12e-01	0.801000
SULFUR AMINO ACID METABOLISM	22	3.65e-01	1.12e-01	0.694000
SLC MEDIATED TRANSMEMBRANE TRANSPORT	186	8.77e-03	1.12e-01	0.103000
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	1.65e-01	1.11e-01	0.471000
SIGNALING BY ROBO RECEPTORS	206	6.05e-03	-1.11e-01	0.085300
RESOLUTION OF SISTER CHROMATID COHESION	101	5.40e-02	-1.11e-01	0.278000
SHC1 EVENTS IN EGFR SIGNALING	10	5.47e-01	-1.10e-01	0.812000
ABC TRANSPORTER DISORDERS	69	1.15e-01	-1.10e-01	0.397000
HATS ACETYLATE HISTONES	92	6.94e-02	1.10e-01	0.309000
PROGRAMMED CELL DEATH	188	9.87e-03	-1.09e-01	0.109000
MAP2K AND MAPK ACTIVATION	36	2.58e-01	1.09e-01	0.582000
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	37	2.56e-01	-1.08e-01	0.580000
PENTOSE PHOSPHATE PATHWAY	13	5.02e-01	-1.07e-01	0.787000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	23	3.74e-01	-1.07e-01	0.694000
ERKS ARE INACTIVATED	13	5.04e-01	1.07e-01	0.787000
PI METABOLISM	79	1.01e-01	1.07e-01	0.376000
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	3.47e-01	1.06e-01	0.679000
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	14	4.92e-01	1.06e-01	0.782000
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	4.23e-01	-1.06e-01	0.733000
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.69e-02	-1.06e-01	0.143000
INTEGRATION OF ENERGY METABOLISM	97	7.26e-02	1.06e-01	0.312000
UNFOLDED PROTEIN RESPONSE UPR	85	9.31e-02	1.05e-01	0.356000
RHO GTPASES ACTIVATE NADPH OXIDASES	18	4.43e-01	1.04e-01	0.750000
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	83	1.00e-01	-1.04e-01	0.375000
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	5.15e-01	-1.04e-01	0.795000
PERK REGULATES GENE EXPRESSION	28	3.40e-01	-1.04e-01	0.676000
PKMTS METHYLATE HISTONE LYSINES	48	2.13e-01	1.04e-01	0.525000
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	5.70e-01	-1.04e-01	0.829000
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	62	1.59e-01	-1.04e-01	0.465000
PHASE II CONJUGATION OF COMPOUNDS	61	1.62e-01	-1.04e-01	0.467000
G0 AND EARLY G1	25	3.71e-01	-1.03e-01	0.694000
FRS MEDIATED FGFR3 SIGNALING	15	4.89e-01	-1.03e-01	0.782000
GLYCOGEN STORAGE DISEASES	12	5.37e-01	1.03e-01	0.811000
ACTIVATION OF MATRIX METALLOPROTEINASES	15	4.90e-01	1.03e-01	0.782000
REGULATED PROTEOLYSIS OF P75NTR	12	5.37e-01	1.03e-01	0.811000
METALLOPROTEASE DUBS	26	3.66e-01	-1.02e-01	0.694000
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	66	1.50e-01	1.02e-01	0.454000
HCMV INFECTION	103	7.34e-02	1.02e-01	0.312000
APOPTOSIS	166	2.33e-02	-1.02e-01	0.168000
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	5.77e-01	-1.02e-01	0.831000
FCERI MEDIATED CA 2 MOBILIZATION	26	3.69e-01	-1.02e-01	0.694000
TRANSLATION	286	3.25e-03	-1.01e-01	0.059000
TRANSCRIPTIONAL REGULATION BY RUNX2	111	6.58e-02	-1.01e-01	0.306000
REPRODUCTION	76	1.28e-01	-1.01e-01	0.418000
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	31	3.32e-01	-1.01e-01	0.667000
EPHRIN SIGNALING	19	4.49e-01	1.00e-01	0.755000
CARDIAC CONDUCTION	108	7.23e-02	1.00e-01	0.312000
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	5.45e-02	-9.96e-02	0.279000
RND3 GTPASE CYCLE	38	2.89e-01	9.95e-02	0.628000
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	15	5.05e-01	9.94e-02	0.787000
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	2.35e-01	9.91e-02	0.557000
LYSINE CATABOLISM	10	5.88e-01	9.91e-02	0.835000
SIGNALING BY FGFR2 IN DISEASE	36	3.05e-01	-9.88e-02	0.644000
NEGATIVE REGULATION OF MAPK PATHWAY	42	2.68e-01	9.88e-02	0.597000
INACTIVATION OF CSF3 G CSF SIGNALING	24	4.02e-01	-9.87e-02	0.716000
TNF SIGNALING	43	2.64e-01	9.84e-02	0.593000
LAGGING STRAND SYNTHESIS	20	4.47e-01	-9.82e-02	0.754000
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	5.40e-01	9.81e-02	0.811000
MRNA SPLICING	188	2.09e-02	-9.78e-02	0.157000
RND2 GTPASE CYCLE	38	2.97e-01	9.77e-02	0.640000
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	5.94e-01	9.74e-02	0.838000
RHOH GTPASE CYCLE	37	3.06e-01	-9.72e-02	0.645000
PLASMA LIPOPROTEIN ASSEMBLY	11	5.77e-01	-9.71e-02	0.831000
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	3.57e-01	9.71e-02	0.694000
RRNA PROCESSING	194	2.00e-02	-9.70e-02	0.156000
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	2.70e-01	9.61e-02	0.600000
DISEASES OF MITOTIC CELL CYCLE	37	3.13e-01	-9.58e-02	0.653000
TRANS GOLGI NETWORK VESICLE BUDDING	69	1.69e-01	-9.57e-02	0.475000
CELLULAR RESPONSE TO STARVATION	145	4.70e-02	-9.56e-02	0.265000
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	1.13e-02	-9.56e-02	0.112000
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	83	1.33e-01	9.55e-02	0.429000
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	4.38e-01	-9.55e-02	0.744000
SIGNAL AMPLIFICATION	30	3.66e-01	-9.54e-02	0.694000
TRANSCRIPTION OF THE HIV GENOME	67	1.78e-01	-9.53e-02	0.483000
SIGNALING BY CSF3 G CSF	29	3.75e-01	-9.52e-02	0.694000
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	344	2.53e-03	-9.50e-02	0.052000
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	3.85e-01	9.49e-02	0.703000
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	5.86e-01	-9.48e-02	0.835000
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	2.94e-01	9.47e-02	0.636000
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	3.69e-01	9.47e-02	0.694000
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	5.13e-01	-9.44e-02	0.795000
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	63	1.95e-01	-9.44e-02	0.505000
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	4.76e-01	9.44e-02	0.776000
ZINC TRANSPORTERS	16	5.18e-01	-9.34e-02	0.797000
MAPK6 MAPK4 SIGNALING	84	1.39e-01	-9.34e-02	0.437000
SIGNALING BY PDGF	57	2.23e-01	9.34e-02	0.536000
INTRA GOLGI TRAFFIC	43	2.90e-01	9.33e-02	0.628000
PREGNENOLONE BIOSYNTHESIS	12	5.77e-01	9.30e-02	0.831000
DEPOLYMERISATION OF THE NUCLEAR LAMINA	13	5.63e-01	9.28e-02	0.827000
ABC FAMILY PROTEINS MEDIATED TRANSPORT	93	1.23e-01	-9.25e-02	0.414000
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	4.97e-01	-9.24e-02	0.784000
RUNX2 REGULATES BONE DEVELOPMENT	29	3.91e-01	9.21e-02	0.707000
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	2.65e-01	9.21e-02	0.593000
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	1.53e-01	9.19e-02	0.460000
ION CHANNEL TRANSPORT	139	6.32e-02	9.14e-02	0.297000
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	63	2.11e-01	9.13e-02	0.523000
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	4.92e-01	-9.11e-02	0.782000
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	3.39e-01	-9.09e-02	0.675000
SELECTIVE AUTOPHAGY	71	1.88e-01	9.05e-02	0.493000
METAL ION SLC TRANSPORTERS	25	4.34e-01	-9.04e-02	0.743000
DNA DAMAGE RECOGNITION IN GG NER	38	3.35e-01	9.04e-02	0.669000
M PHASE	339	4.38e-03	-9.02e-02	0.067100
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	4.18e-01	9.01e-02	0.727000
CYCLIN D ASSOCIATED EVENTS IN G1	45	2.97e-01	-9.00e-02	0.639000
METABOLISM OF RNA	644	1.07e-04	-8.99e-02	0.010400
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	101	1.19e-01	8.98e-02	0.409000
PINK1 PRKN MEDIATED MITOPHAGY	22	4.66e-01	-8.97e-02	0.768000
SIGNALING BY PTK6	50	2.73e-01	8.97e-02	0.603000
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	3.74e-01	-8.94e-02	0.694000
ION HOMEOSTASIS	49	2.80e-01	8.92e-02	0.614000
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	4.80e-01	8.91e-02	0.779000
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	3.91e-01	8.90e-02	0.707000
PROLACTIN RECEPTOR SIGNALING	11	6.11e-01	-8.86e-02	0.845000
FLT3 SIGNALING IN DISEASE	27	4.27e-01	-8.84e-02	0.737000
PHASE 0 RAPID DEPOLARISATION	29	4.11e-01	8.83e-02	0.724000
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	6.30e-01	8.81e-02	0.860000
INTERLEUKIN 7 SIGNALING	20	4.96e-01	8.80e-02	0.784000
CELL CYCLE	593	2.74e-04	-8.78e-02	0.017400
PURINE SALVAGE	12	5.99e-01	-8.78e-02	0.838000
METABOLISM OF AMINO ACIDS AND DERIVATIVES	314	7.76e-03	-8.76e-02	0.098600
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	2.77e-01	8.72e-02	0.611000
OTHER INTERLEUKIN SIGNALING	19	5.13e-01	8.66e-02	0.795000
AMYLOID FIBER FORMATION	57	2.60e-01	8.63e-02	0.585000
SIGNALING BY BRAF AND RAF FUSIONS	60	2.52e-01	8.55e-02	0.578000
SIGNALING BY TGFB FAMILY MEMBERS	96	1.49e-01	-8.52e-02	0.452000
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	4.80e-01	-8.50e-02	0.779000
TELOMERE C STRAND SYNTHESIS INITIATION	13	5.96e-01	-8.49e-02	0.838000
G1 S SPECIFIC TRANSCRIPTION	26	4.55e-01	-8.47e-02	0.758000
ONCOGENIC MAPK SIGNALING	77	1.99e-01	8.46e-02	0.511000
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	17	5.46e-01	-8.46e-02	0.811000
SIGNALING BY NTRKS	129	9.75e-02	8.46e-02	0.370000
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	2.40e-01	-8.44e-02	0.561000
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	5.27e-01	8.39e-02	0.805000
CELL CYCLE MITOTIC	475	1.86e-03	-8.36e-02	0.043300
FORMATION OF THE EARLY ELONGATION COMPLEX	33	4.06e-01	8.36e-02	0.719000
GAP JUNCTION DEGRADATION	11	6.31e-01	8.35e-02	0.860000
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	4.62e-01	-8.34e-02	0.766000
DAP12 SIGNALING	24	4.80e-01	-8.33e-02	0.779000
NUCLEOBASE CATABOLISM	31	4.23e-01	-8.31e-02	0.733000
SPHINGOLIPID DE NOVO BIOSYNTHESIS	42	3.52e-01	-8.31e-02	0.686000
RESOLUTION OF D LOOP STRUCTURES	30	4.32e-01	-8.30e-02	0.741000
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	5.24e-01	8.24e-02	0.803000
APOPTOTIC FACTOR MEDIATED RESPONSE	18	5.46e-01	-8.22e-02	0.811000
INTEGRIN CELL SURFACE INTERACTIONS	71	2.35e-01	8.16e-02	0.557000
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	5.60e-01	8.16e-02	0.827000
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	6.25e-01	8.16e-02	0.858000
VEGFR2 MEDIATED CELL PROLIFERATION	19	5.39e-01	-8.15e-02	0.811000
RHO GTPASES ACTIVATE CIT	18	5.51e-01	8.12e-02	0.815000
TRANSCRIPTIONAL REGULATION BY VENTX	35	4.06e-01	8.12e-02	0.719000
MUSCLE CONTRACTION	163	7.43e-02	8.11e-02	0.314000
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	87	1.92e-01	-8.10e-02	0.501000
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	5.87e-01	-8.10e-02	0.835000
INWARDLY RECTIFYING K CHANNELS	31	4.35e-01	-8.09e-02	0.743000
ACYL CHAIN REMODELLING OF PG	10	6.58e-01	-8.08e-02	0.877000
GLUCAGON TYPE LIGAND RECEPTORS	25	4.85e-01	-8.07e-02	0.782000
METABOLISM OF VITAMINS AND COFACTORS	150	8.87e-02	8.06e-02	0.353000
DAG AND IP3 SIGNALING	40	3.79e-01	8.04e-02	0.698000
INTERLEUKIN 1 SIGNALING	96	1.75e-01	-8.02e-02	0.479000
PECAM1 INTERACTIONS	12	6.31e-01	8.02e-02	0.860000
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	22	5.15e-01	8.01e-02	0.795000
LDL CLEARANCE	16	5.80e-01	8.00e-02	0.831000
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	25	4.89e-01	-8.00e-02	0.782000
GLYCOSPHINGOLIPID METABOLISM	39	3.89e-01	7.98e-02	0.707000
INSULIN RECEPTOR RECYCLING	20	5.37e-01	-7.97e-02	0.811000
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	4.69e-01	-7.91e-02	0.770000
REGULATION OF LIPID METABOLISM BY PPARALPHA	107	1.58e-01	7.90e-02	0.465000
GOLGI TO ER RETROGRADE TRANSPORT	119	1.37e-01	7.89e-02	0.436000
RAP1 SIGNALLING	15	5.97e-01	-7.89e-02	0.838000
HIV LIFE CYCLE	142	1.05e-01	-7.89e-02	0.381000
CYTOKINE SIGNALING IN IMMUNE SYSTEM	544	1.77e-03	-7.87e-02	0.043300
CD209 DC SIGN SIGNALING	18	5.64e-01	-7.86e-02	0.827000
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	84	2.14e-01	-7.85e-02	0.526000
CELL CELL COMMUNICATION	107	1.62e-01	7.84e-02	0.467000
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	2.47e-01	-7.79e-02	0.568000
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	5.18e-01	-7.78e-02	0.797000
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	6.41e-01	7.78e-02	0.869000
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	2.17e-01	7.76e-02	0.530000
INTERLEUKIN 35 SIGNALLING	10	6.74e-01	-7.68e-02	0.879000
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	5.64e-01	-7.64e-02	0.827000
SIGNALING BY GPCR	462	5.28e-03	7.60e-02	0.077200
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	6.00e-01	-7.57e-02	0.838000
ERK MAPK TARGETS	22	5.39e-01	7.56e-02	0.811000
NONHOMOLOGOUS END JOINING NHEJ	43	3.91e-01	-7.56e-02	0.707000
SHC1 EVENTS IN ERBB2 SIGNALING	20	5.61e-01	-7.51e-02	0.827000
RHO GTPASE CYCLE	422	8.63e-03	7.48e-02	0.103000
RNA POLYMERASE II TRANSCRIPTION	1085	3.93e-05	-7.45e-02	0.004180
MITOTIC PROMETAPHASE	176	8.91e-02	-7.44e-02	0.353000
RRNA PROCESSING IN THE MITOCHONDRION	10	6.84e-01	-7.44e-02	0.883000
SIGNALING BY NTRK3 TRKC	17	5.98e-01	7.38e-02	0.838000
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	6.73e-01	7.36e-02	0.879000
GLYCOLYSIS	66	3.02e-01	7.35e-02	0.644000
HCMV LATE EVENTS	65	3.08e-01	7.32e-02	0.646000
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	3.33e-01	7.29e-02	0.667000
RHO GTPASES ACTIVATE KTN1	11	6.76e-01	-7.27e-02	0.879000
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	3.35e-01	-7.26e-02	0.669000
CONDENSATION OF PROPHASE CHROMOSOMES	27	5.14e-01	-7.25e-02	0.795000
NEGATIVE REGULATION OF MET ACTIVITY	21	5.66e-01	-7.24e-02	0.827000
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	4.80e-01	-7.22e-02	0.779000
GENERATION OF SECOND MESSENGER MOLECULES	19	5.86e-01	-7.21e-02	0.835000
REGULATION OF PTEN GENE TRANSCRIPTION	58	3.43e-01	7.21e-02	0.676000
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	61	3.31e-01	7.20e-02	0.667000
KERATAN SULFATE DEGRADATION	11	6.80e-01	7.18e-02	0.880000
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	3.41e-01	7.17e-02	0.676000
ACTIVATION OF BH3 ONLY PROTEINS	30	4.97e-01	-7.16e-02	0.784000
NGF STIMULATED TRANSCRIPTION	37	4.54e-01	7.11e-02	0.758000
EPH EPHRIN SIGNALING	92	2.40e-01	7.10e-02	0.561000
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	286	4.04e-02	-7.06e-02	0.242000
SIGNALING BY HEDGEHOG	142	1.49e-01	7.02e-02	0.452000
SYNTHESIS OF PC	25	5.46e-01	6.97e-02	0.811000
PLATELET HOMEOSTASIS	78	2.89e-01	-6.94e-02	0.628000
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	31	5.04e-01	6.94e-02	0.787000
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	23	5.65e-01	-6.93e-02	0.827000
SIGNALING BY SCF KIT	41	4.44e-01	-6.91e-02	0.750000
TRNA AMINOACYLATION	42	4.39e-01	6.91e-02	0.744000
INTERLEUKIN RECEPTOR SHC SIGNALING	20	5.93e-01	6.90e-02	0.838000
SIGNALING BY EGFR	46	4.19e-01	6.90e-02	0.727000
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	7.06e-01	-6.89e-02	0.893000
PEROXISOMAL PROTEIN IMPORT	57	3.69e-01	-6.89e-02	0.694000
CELLULAR SENESCENCE	141	1.59e-01	6.88e-02	0.465000
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	63	3.46e-01	-6.87e-02	0.678000
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	6.24e-01	6.86e-02	0.858000
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	5.79e-01	6.84e-02	0.831000
SUMOYLATION	161	1.37e-01	-6.80e-02	0.436000
UB SPECIFIC PROCESSING PROTEASES	169	1.27e-01	-6.80e-02	0.418000
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	5.73e-01	-6.79e-02	0.830000
CELLULAR RESPONSE TO CHEMICAL STRESS	150	1.53e-01	-6.76e-02	0.460000
NEURONAL SYSTEM	366	2.68e-02	6.76e-02	0.181000
SIGNALING BY ERYTHROPOIETIN	24	5.67e-01	6.74e-02	0.827000
RESPONSE OF MTB TO PHAGOCYTOSIS	21	5.94e-01	6.71e-02	0.838000
MET PROMOTES CELL MOTILITY	39	4.70e-01	6.69e-02	0.771000
RAS PROCESSING	24	5.71e-01	-6.68e-02	0.829000
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	6.44e-01	6.68e-02	0.869000
CYTOPROTECTION BY HMOX1	120	2.09e-01	-6.64e-02	0.522000
INTRAFLAGELLAR TRANSPORT	50	4.19e-01	6.61e-02	0.727000
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	4.60e-01	6.59e-02	0.765000
RHOJ GTPASE CYCLE	54	4.03e-01	-6.58e-02	0.716000
POLYMERASE SWITCHING	14	6.70e-01	-6.57e-02	0.879000
TRIGLYCERIDE METABOLISM	23	5.87e-01	-6.54e-02	0.835000
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	6.15e-01	-6.49e-02	0.850000
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	6.99e-01	-6.45e-02	0.891000
SIGNALING BY FGFR IN DISEASE	55	4.08e-01	-6.45e-02	0.720000
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	7.24e-01	-6.45e-02	0.895000
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	7.24e-01	-6.45e-02	0.895000
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	5.42e-01	-6.44e-02	0.811000
ERBB2 ACTIVATES PTK6 SIGNALING	10	7.25e-01	6.43e-02	0.895000
AUTOPHAGY	137	1.95e-01	6.42e-02	0.505000
PLATELET CALCIUM HOMEOSTASIS	27	5.64e-01	6.41e-02	0.827000
SIGNALING BY NOTCH4	83	3.14e-01	-6.39e-02	0.653000
LATE ENDOSOMAL MICROAUTOPHAGY	30	5.46e-01	6.38e-02	0.811000
N GLYCAN ANTENNAE ELONGATION	15	6.69e-01	6.37e-02	0.879000
CHROMOSOME MAINTENANCE	101	2.71e-01	-6.34e-02	0.600000
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	6.76e-01	-6.24e-02	0.879000
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	6.98e-01	6.21e-02	0.891000
PI3K EVENTS IN ERBB2 SIGNALING	14	6.88e-01	-6.19e-02	0.884000
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	622	8.69e-03	6.19e-02	0.103000
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	7.23e-01	6.17e-02	0.895000
ANTIMICROBIAL PEPTIDES	12	7.12e-01	6.16e-02	0.895000
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	5.94e-01	-6.15e-02	0.838000
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	5.88e-01	-6.14e-02	0.835000
EGFR DOWNREGULATION	27	5.81e-01	6.14e-02	0.832000
DEVELOPMENTAL BIOLOGY	813	3.12e-03	6.13e-02	0.058000
NEDDYLATION	218	1.20e-01	-6.12e-02	0.409000
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	4.89e-01	-6.10e-02	0.782000
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	143	2.11e-01	-6.06e-02	0.523000
ADAPTIVE IMMUNE SYSTEM	599	1.18e-02	-6.05e-02	0.114000
SUMOYLATION OF TRANSCRIPTION FACTORS	16	6.76e-01	-6.04e-02	0.879000
ASPARAGINE N LINKED GLYCOSYLATION	282	8.51e-02	5.97e-02	0.342000
FOXO MEDIATED TRANSCRIPTION	57	4.36e-01	-5.96e-02	0.743000
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	89	3.32e-01	5.95e-02	0.667000
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	62	4.18e-01	5.95e-02	0.727000
IRAK1 RECRUITS IKK COMPLEX	14	7.01e-01	5.94e-02	0.892000
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	5.43e-01	-5.94e-02	0.811000
POTENTIAL THERAPEUTICS FOR SARS	77	3.73e-01	5.88e-02	0.694000
PROTEIN LOCALIZATION	156	2.09e-01	-5.84e-02	0.522000
SIGNALING BY NODAL	16	6.86e-01	5.84e-02	0.884000
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	5.56e-01	-5.83e-02	0.822000
ERYTHROPOIETIN ACTIVATES RAS	13	7.17e-01	-5.81e-02	0.895000
REGULATION OF IFNA SIGNALING	12	7.29e-01	5.79e-02	0.897000
ERBB2 REGULATES CELL MOTILITY	13	7.20e-01	-5.75e-02	0.895000
TP53 REGULATES METABOLIC GENES	85	3.64e-01	-5.70e-02	0.694000
RHOD GTPASE CYCLE	50	4.87e-01	-5.68e-02	0.782000
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	7.56e-01	-5.68e-02	0.909000
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	7.34e-01	5.67e-02	0.900000
CLASS B 2 SECRETIN FAMILY RECEPTORS	70	4.13e-01	5.67e-02	0.726000
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	7.24e-01	-5.66e-02	0.895000
TNFR2 NON CANONICAL NF KB PATHWAY	83	3.74e-01	-5.65e-02	0.694000
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	7.35e-01	-5.64e-02	0.900000
MTOR SIGNALLING	40	5.38e-01	-5.62e-02	0.811000
SIGNALING BY FGFR1	42	5.29e-01	-5.62e-02	0.806000
DNA STRAND ELONGATION	32	5.85e-01	-5.59e-02	0.835000
METABOLISM OF NUCLEOTIDES	92	3.55e-01	-5.58e-02	0.691000
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	16	6.99e-01	-5.58e-02	0.891000
INTRINSIC PATHWAY FOR APOPTOSIS	52	4.87e-01	-5.57e-02	0.782000
TRAF6 MEDIATED NF KB ACTIVATION	22	6.51e-01	5.57e-02	0.872000
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	20	6.67e-01	-5.56e-02	0.879000
SIGNALING BY ACTIVIN	12	7.39e-01	-5.56e-02	0.901000
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	4.49e-01	5.56e-02	0.755000
VIRAL MESSENGER RNA SYNTHESIS	42	5.34e-01	5.55e-02	0.811000
ION TRANSPORT BY P TYPE ATPASES	48	5.06e-01	5.55e-02	0.787000
POTASSIUM CHANNELS	90	3.64e-01	5.54e-02	0.694000
OPIOID SIGNALLING	86	3.76e-01	-5.53e-02	0.694000
RHOF GTPASE CYCLE	40	5.46e-01	-5.52e-02	0.811000
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	7.52e-01	5.51e-02	0.905000
PI3K AKT SIGNALING IN CANCER	87	3.76e-01	5.49e-02	0.694000
THE NLRP3 INFLAMMASOME	15	7.17e-01	-5.41e-02	0.895000
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	6.02e-01	-5.41e-02	0.838000
SIGNALING BY NOTCH	189	2.01e-01	5.40e-02	0.512000
RHOV GTPASE CYCLE	32	5.98e-01	-5.39e-02	0.838000
PARASITE INFECTION	54	4.94e-01	5.39e-02	0.783000
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	6.48e-01	5.39e-02	0.870000
NEUTROPHIL DEGRANULATION	384	7.12e-02	-5.38e-02	0.311000
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	110	3.33e-01	5.35e-02	0.667000
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	7.49e-01	5.34e-02	0.904000
SIGNALING BY INSULIN RECEPTOR	61	4.71e-01	-5.33e-02	0.772000
OVARIAN TUMOR DOMAIN PROTEASES	36	5.80e-01	-5.33e-02	0.831000
MRNA SPLICING MINOR PATHWAY	52	5.06e-01	5.33e-02	0.787000
INTERLEUKIN 2 FAMILY SIGNALING	32	6.02e-01	5.33e-02	0.838000
MAPK FAMILY SIGNALING CASCADES	286	1.22e-01	5.32e-02	0.414000
NUCLEOTIDE SALVAGE	21	6.75e-01	5.29e-02	0.879000
RAB REGULATION OF TRAFFICKING	119	3.20e-01	5.28e-02	0.658000
CTLA4 INHIBITORY SIGNALING	20	6.83e-01	-5.28e-02	0.883000
MHC CLASS II ANTIGEN PRESENTATION	102	3.58e-01	5.27e-02	0.694000
MITOCHONDRIAL TRANSLATION	93	3.81e-01	-5.26e-02	0.698000
MITOTIC G2 G2 M PHASES	186	2.18e-01	-5.25e-02	0.532000
CHEMOKINE RECEPTORS BIND CHEMOKINES	17	7.08e-01	-5.24e-02	0.894000
MITOPHAGY	29	6.27e-01	-5.22e-02	0.859000
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	7.37e-01	-5.18e-02	0.900000
HEME SIGNALING	45	5.48e-01	-5.17e-02	0.812000
MITOTIC PROPHASE	94	3.88e-01	-5.16e-02	0.707000
COPII MEDIATED VESICLE TRANSPORT	64	4.76e-01	5.15e-02	0.776000
SIGNALING BY ERBB2	47	5.43e-01	-5.14e-02	0.811000
IRS MEDIATED SIGNALLING	37	5.90e-01	-5.12e-02	0.836000
HEDGEHOG OFF STATE	107	3.62e-01	5.10e-02	0.694000
SNRNP ASSEMBLY	51	5.30e-01	-5.09e-02	0.807000
DOWNREGULATION OF ERBB2 SIGNALING	27	6.48e-01	5.07e-02	0.870000
CELL JUNCTION ORGANIZATION	75	4.52e-01	5.02e-02	0.757000
DCC MEDIATED ATTRACTIVE SIGNALING	14	7.46e-01	5.00e-02	0.902000
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	84	4.32e-01	-4.96e-02	0.741000
INTERLEUKIN 1 FAMILY SIGNALING	122	3.45e-01	-4.96e-02	0.678000
DEUBIQUITINATION	243	1.88e-01	-4.91e-02	0.493000
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	7.42e-01	-4.91e-02	0.902000
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	6.66e-01	-4.90e-02	0.879000
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	2.51e-01	4.89e-02	0.577000
SIGNAL TRANSDUCTION BY L1	21	6.98e-01	4.89e-02	0.891000
SIGNALING BY NTRK2 TRKB	24	6.79e-01	-4.88e-02	0.880000
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	7.06e-01	4.87e-02	0.893000
SIGNALING BY RETINOIC ACID	34	6.25e-01	-4.84e-02	0.858000
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	77	4.65e-01	-4.82e-02	0.766000
BETA CATENIN INDEPENDENT WNT SIGNALING	139	3.28e-01	-4.81e-02	0.666000
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	25	6.77e-01	-4.81e-02	0.879000
SIGNALING BY RECEPTOR TYROSINE KINASES	459	8.11e-02	4.77e-02	0.335000
GPVI MEDIATED ACTIVATION CASCADE	31	6.46e-01	4.76e-02	0.870000
HDR THROUGH MMEJ ALT NHEJ	10	7.96e-01	-4.73e-02	0.931000
CHAPERONE MEDIATED AUTOPHAGY	19	7.21e-01	-4.73e-02	0.895000
HEMOSTASIS	474	7.93e-02	4.72e-02	0.330000
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	6.02e-01	4.71e-02	0.838000
GLYCOGEN METABOLISM	25	6.84e-01	-4.70e-02	0.883000
TRANSCRIPTIONAL REGULATION BY RUNX1	179	2.80e-01	4.69e-02	0.614000
CA DEPENDENT EVENTS	36	6.28e-01	4.67e-02	0.859000
CLATHRIN MEDIATED ENDOCYTOSIS	130	3.60e-01	4.65e-02	0.694000
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	4.95e-01	-4.65e-02	0.784000
SUMOYLATION OF DNA REPLICATION PROTEINS	43	5.98e-01	-4.65e-02	0.838000
HYALURONAN UPTAKE AND DEGRADATION	11	7.90e-01	4.64e-02	0.931000
EXTENSION OF TELOMERES	49	5.77e-01	-4.61e-02	0.831000
HIV TRANSCRIPTION ELONGATION	42	6.06e-01	4.60e-02	0.841000
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	7.66e-01	-4.59e-02	0.916000
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	6.80e-01	4.58e-02	0.880000
SIGNALING BY INTERLEUKINS	348	1.44e-01	-4.57e-02	0.444000
INSULIN RECEPTOR SIGNALLING CASCADE	42	6.09e-01	-4.56e-02	0.845000
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	21	7.18e-01	4.55e-02	0.895000
TIGHT JUNCTION INTERACTIONS	20	7.26e-01	4.52e-02	0.896000
NERVOUS SYSTEM DEVELOPMENT	547	7.21e-02	4.51e-02	0.312000
INHIBITION OF DNA RECOMBINATION AT TELOMERE	35	6.44e-01	4.51e-02	0.869000
INTERLEUKIN 27 SIGNALING	10	8.05e-01	4.50e-02	0.937000
SIGNALING BY MET	75	5.02e-01	4.49e-02	0.787000
RHO GTPASES ACTIVATE ROCKS	19	7.35e-01	4.48e-02	0.900000
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	6.69e-01	-4.44e-02	0.879000
NUCLEAR SIGNALING BY ERBB4	30	6.74e-01	4.43e-02	0.879000
SUMOYLATION OF SUMOYLATION PROTEINS	33	6.60e-01	-4.42e-02	0.878000
RHO GTPASES ACTIVATE PKNS	47	6.01e-01	-4.41e-02	0.838000
EPHB MEDIATED FORWARD SIGNALING	42	6.22e-01	4.39e-02	0.857000
AQUAPORIN MEDIATED TRANSPORT	40	6.32e-01	-4.37e-02	0.860000
LEISHMANIA INFECTION	189	3.04e-01	4.34e-02	0.644000
SUPPRESSION OF PHAGOSOMAL MATURATION	12	7.95e-01	-4.33e-02	0.931000
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	7.81e-01	4.28e-02	0.930000
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	37	6.53e-01	-4.27e-02	0.872000
SIGNALING BY VEGF	101	4.60e-01	4.26e-02	0.765000
VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	7.08e-01	-4.25e-02	0.894000
NUCLEOBASE BIOSYNTHESIS	15	7.76e-01	4.24e-02	0.926000
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	6.55e-01	-4.20e-02	0.873000
SIGNALING BY EGFR IN CANCER	21	7.40e-01	-4.18e-02	0.901000
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	7.59e-01	-4.18e-02	0.911000
RHOG GTPASE CYCLE	73	5.43e-01	4.12e-02	0.811000
FCGR3A MEDIATED IL10 SYNTHESIS	32	6.87e-01	4.12e-02	0.884000
COMPLEMENT CASCADE	24	7.31e-01	-4.06e-02	0.898000
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	43	6.46e-01	-4.06e-02	0.870000
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	63	5.80e-01	-4.04e-02	0.831000
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	68	5.67e-01	-4.01e-02	0.827000
DUAL INCISION IN TC NER	65	5.77e-01	-4.00e-02	0.831000
ACYL CHAIN REMODELLING OF PC	17	7.76e-01	3.98e-02	0.926000
SIGNALLING TO ERKS	32	6.99e-01	3.95e-02	0.891000
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	7.13e-01	-3.94e-02	0.895000
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	7.50e-01	3.92e-02	0.904000
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	7.20e-01	-3.92e-02	0.895000
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	24	7.41e-01	-3.90e-02	0.901000
INNATE IMMUNE SYSTEM	773	6.73e-02	-3.89e-02	0.306000
NICOTINAMIDE SALVAGING	15	7.97e-01	-3.84e-02	0.931000
PLATELET SENSITIZATION BY LDL	15	7.99e-01	-3.80e-02	0.932000
HSF1 ACTIVATION	27	7.34e-01	3.78e-02	0.900000
ESR MEDIATED SIGNALING	163	4.07e-01	-3.77e-02	0.719000
GPCR LIGAND BINDING	247	3.10e-01	3.76e-02	0.649000
PHASE I FUNCTIONALIZATION OF COMPOUNDS	58	6.22e-01	3.74e-02	0.857000
SUMOYLATION OF RNA BINDING PROTEINS	45	6.65e-01	-3.73e-02	0.879000
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	8.38e-01	-3.73e-02	0.948000
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	8.38e-01	-3.73e-02	0.948000
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	8.19e-01	3.67e-02	0.946000
TRANSPORT OF SMALL MOLECULES	569	1.39e-01	3.64e-02	0.437000
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	6.63e-01	3.63e-02	0.879000
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	6.67e-01	3.63e-02	0.879000
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	7.40e-01	3.63e-02	0.901000
INFECTIOUS DISEASE	722	9.97e-02	-3.62e-02	0.375000
G PROTEIN MEDIATED EVENTS	52	6.52e-01	3.61e-02	0.872000
NUCLEAR ENVELOPE NE REASSEMBLY	64	6.22e-01	3.56e-02	0.857000
NOD1 2 SIGNALING PATHWAY	34	7.20e-01	3.56e-02	0.895000
RHO GTPASES ACTIVATE WASPS AND WAVES	36	7.14e-01	-3.53e-02	0.895000
NEGATIVE REGULATION OF FGFR1 SIGNALING	25	7.61e-01	3.52e-02	0.912000
RECEPTOR MEDIATED MITOPHAGY	11	8.40e-01	-3.51e-02	0.950000
VXPX CARGO TARGETING TO CILIUM	19	7.91e-01	-3.51e-02	0.931000
RHOQ GTPASE CYCLE	57	6.47e-01	3.51e-02	0.870000
TRANSCRIPTIONAL REGULATION BY RUNX3	92	5.68e-01	-3.45e-02	0.827000
METABOLISM OF STEROIDS	112	5.30e-01	-3.44e-02	0.807000
CELLULAR RESPONSES TO EXTERNAL STIMULI	600	1.55e-01	-3.42e-02	0.461000
RHO GTPASES ACTIVATE FORMINS	118	5.25e-01	-3.39e-02	0.804000
CELL CELL JUNCTION ORGANIZATION	51	6.76e-01	-3.38e-02	0.879000
FORMATION OF TC NER PRE INCISION COMPLEX	53	6.70e-01	-3.38e-02	0.879000
RHO GTPASES ACTIVATE PAKS	21	7.89e-01	-3.37e-02	0.931000
ARACHIDONIC ACID METABOLISM	39	7.17e-01	3.35e-02	0.895000
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	8.25e-01	-3.30e-02	0.947000
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	7.06e-01	3.29e-02	0.893000
GENE SILENCING BY RNA	83	6.11e-01	3.24e-02	0.845000
VESICLE MEDIATED TRANSPORT	605	1.77e-01	3.23e-02	0.482000
FATTY ACID METABOLISM	145	5.04e-01	-3.22e-02	0.787000
METABOLISM OF STEROID HORMONES	20	8.03e-01	-3.22e-02	0.935000
SIGNALING BY WNT IN CANCER	30	7.61e-01	3.20e-02	0.912000
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	8.43e-01	3.18e-02	0.950000
G ALPHA Z SIGNALLING EVENTS	45	7.13e-01	-3.17e-02	0.895000
SURFACTANT METABOLISM	17	8.21e-01	3.16e-02	0.947000
DISEASES OF IMMUNE SYSTEM	24	7.89e-01	3.15e-02	0.931000
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	6.89e-01	3.15e-02	0.884000
METABOLISM OF LIPIDS	610	1.86e-01	3.15e-02	0.493000
NICOTINATE METABOLISM	24	7.91e-01	3.13e-02	0.931000
BASIGIN INTERACTIONS	23	7.97e-01	3.09e-02	0.931000
TRANSMISSION ACROSS CHEMICAL SYNAPSES	238	4.14e-01	3.08e-02	0.726000
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	6.43e-01	3.08e-02	0.869000
MEMBRANE TRAFFICKING	576	2.15e-01	3.03e-02	0.528000
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	85	6.30e-01	3.02e-02	0.860000
FGFR2 ALTERNATIVE SPLICING	25	7.95e-01	3.00e-02	0.931000
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	11	8.64e-01	-2.99e-02	0.959000
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	41	7.46e-01	-2.93e-02	0.902000
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	6.93e-01	2.92e-02	0.889000
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	13	8.57e-01	-2.88e-02	0.955000
MRNA CAPPING	29	7.89e-01	-2.87e-02	0.931000
PLATELET ACTIVATION SIGNALING AND AGGREGATION	223	4.64e-01	2.85e-02	0.766000
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	8.60e-01	-2.82e-02	0.957000
REGULATION OF KIT SIGNALING	16	8.45e-01	-2.82e-02	0.950000
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	88	6.50e-01	-2.80e-02	0.871000
CARGO CONCENTRATION IN THE ER	30	7.92e-01	2.78e-02	0.931000
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	12	8.69e-01	2.75e-02	0.962000
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	6.43e-01	2.74e-02	0.869000
RNA POLYMERASE I PROMOTER ESCAPE	47	7.45e-01	-2.74e-02	0.902000
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	8.55e-01	2.73e-02	0.954000
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	8.25e-01	-2.73e-02	0.947000
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	8.11e-01	2.71e-02	0.942000
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	8.16e-01	-2.69e-02	0.945000
RNA POLYMERASE III CHAIN ELONGATION	18	8.46e-01	-2.65e-02	0.950000
HOMOLOGY DIRECTED REPAIR	108	6.36e-01	-2.63e-02	0.865000
RNA POLYMERASE I TRANSCRIPTION	67	7.12e-01	2.61e-02	0.895000
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	47	7.58e-01	2.60e-02	0.911000
BASE EXCISION REPAIR	57	7.36e-01	2.58e-02	0.900000
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	8.73e-01	-2.56e-02	0.962000
TOLL LIKE RECEPTOR CASCADES	138	6.06e-01	-2.55e-02	0.841000
REGULATION OF TP53 EXPRESSION AND DEGRADATION	35	7.95e-01	-2.54e-02	0.931000
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	7.02e-01	-2.49e-02	0.893000
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	8.49e-01	2.47e-02	0.950000
TRANSCRIPTIONAL REGULATION BY TP53	342	4.35e-01	-2.46e-02	0.743000
REGULATION OF SIGNALING BY CBL	22	8.42e-01	-2.46e-02	0.950000
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	27	8.26e-01	-2.45e-02	0.947000
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	7.83e-01	2.43e-02	0.930000
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	8.85e-01	2.40e-02	0.965000
BASE EXCISION REPAIR AP SITE FORMATION	29	8.25e-01	2.38e-02	0.947000
SIGNALING BY WNT	268	5.04e-01	-2.37e-02	0.787000
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	8.67e-01	2.36e-02	0.961000
CLASS A 1 RHODOPSIN LIKE RECEPTORS	166	6.01e-01	2.35e-02	0.838000
STRIATED MUSCLE CONTRACTION	28	8.30e-01	2.34e-02	0.947000
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	8.37e-01	2.33e-02	0.948000
RND1 GTPASE CYCLE	37	8.10e-01	-2.29e-02	0.941000
RAF ACTIVATION	34	8.18e-01	-2.28e-02	0.946000
POLO LIKE KINASE MEDIATED EVENTS	14	8.84e-01	-2.26e-02	0.965000
BIOLOGICAL OXIDATIONS	122	6.67e-01	-2.26e-02	0.879000
REGULATION OF INSULIN SECRETION	71	7.45e-01	2.24e-02	0.902000
SCAVENGING BY CLASS A RECEPTORS	13	8.90e-01	2.22e-02	0.967000
SIGNALING BY NUCLEAR RECEPTORS	221	5.70e-01	-2.22e-02	0.829000
RAC2 GTPASE CYCLE	86	7.23e-01	-2.22e-02	0.895000
UCH PROTEINASES	90	7.18e-01	-2.21e-02	0.895000
DOWNSTREAM SIGNAL TRANSDUCTION	29	8.38e-01	2.19e-02	0.948000
EPIGENETIC REGULATION OF GENE EXPRESSION	103	7.03e-01	2.18e-02	0.893000
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	92	7.19e-01	2.17e-02	0.895000
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	8.44e-01	-2.15e-02	0.950000
INTERLEUKIN 17 SIGNALING	66	7.63e-01	2.15e-02	0.913000
SARS COV INFECTIONS	140	6.62e-01	2.14e-02	0.879000
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	280	5.47e-01	2.10e-02	0.811000
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	8.23e-01	-2.10e-02	0.947000
RA BIOSYNTHESIS PATHWAY	14	8.92e-01	-2.09e-02	0.969000
CD28 DEPENDENT PI3K AKT SIGNALING	20	8.72e-01	2.08e-02	0.962000
DEFECTS IN COBALAMIN B12 METABOLISM	12	9.01e-01	-2.07e-02	0.975000
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	85	7.44e-01	-2.05e-02	0.902000
SIGNALING BY FGFR4	32	8.41e-01	-2.05e-02	0.950000
FERTILIZATION	12	9.03e-01	-2.04e-02	0.975000
SENSORY PERCEPTION	149	6.70e-01	2.02e-02	0.879000
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	30	8.48e-01	2.02e-02	0.950000
RAC3 GTPASE CYCLE	88	7.50e-01	-1.97e-02	0.904000
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	8.37e-01	-1.96e-02	0.948000
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	8.28e-01	1.96e-02	0.947000
MITOCHONDRIAL PROTEIN IMPORT	63	7.90e-01	-1.94e-02	0.931000
NEGATIVE REGULATION OF FGFR4 SIGNALING	22	8.77e-01	1.91e-02	0.965000
PTEN REGULATION	134	7.04e-01	-1.90e-02	0.893000
LYSOSOME VESICLE BIOGENESIS	32	8.53e-01	-1.89e-02	0.953000
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	8.71e-01	-1.88e-02	0.962000
G ALPHA Q SIGNALLING EVENTS	146	6.97e-01	-1.87e-02	0.891000
CIRCADIAN CLOCK	68	7.91e-01	1.86e-02	0.931000
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	8.34e-01	1.84e-02	0.948000
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	32	8.57e-01	1.84e-02	0.955000
SYNDECAN INTERACTIONS	26	8.73e-01	1.81e-02	0.962000
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	9.14e-01	-1.81e-02	0.977000
SARS COV 1 INFECTION	48	8.33e-01	-1.76e-02	0.948000
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	57	8.19e-01	-1.75e-02	0.946000
SEMA3A PAK DEPENDENT AXON REPULSION	16	9.06e-01	1.71e-02	0.977000
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	41	8.51e-01	1.70e-02	0.951000
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	8.88e-01	1.69e-02	0.967000
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	57	8.26e-01	1.68e-02	0.947000
BUDDING AND MATURATION OF HIV VIRION	27	8.80e-01	-1.68e-02	0.965000
TRAF6 MEDIATED IRF7 ACTIVATION	15	9.11e-01	-1.67e-02	0.977000
SARS COV 2 INFECTION	65	8.16e-01	-1.67e-02	0.945000
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	8.48e-01	1.65e-02	0.950000
PEPTIDE LIGAND BINDING RECEPTORS	96	7.80e-01	-1.65e-02	0.929000
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	78	8.01e-01	-1.65e-02	0.934000
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	29	8.82e-01	-1.59e-02	0.965000
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	9.12e-01	1.59e-02	0.977000
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	90	7.94e-01	-1.59e-02	0.931000
RNA POLYMERASE III TRANSCRIPTION	41	8.60e-01	-1.59e-02	0.957000
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	93	7.92e-01	1.58e-02	0.931000
PIWI INTERACTING RNA PIRNA BIOGENESIS	20	9.03e-01	-1.57e-02	0.975000
PKA MEDIATED PHOSPHORYLATION OF CREB	19	9.06e-01	-1.56e-02	0.977000
VISUAL PHOTOTRANSDUCTION	60	8.35e-01	1.55e-02	0.948000
GLUTATHIONE CONJUGATION	29	8.85e-01	-1.55e-02	0.965000
CYTOSOLIC TRNA AMINOACYLATION	24	8.96e-01	-1.54e-02	0.972000
FLT3 SIGNALING	37	8.72e-01	-1.54e-02	0.962000
EPHA MEDIATED GROWTH CONE COLLAPSE	29	8.87e-01	-1.52e-02	0.966000
NUCLEOTIDE EXCISION REPAIR	110	7.82e-01	-1.52e-02	0.930000
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	8.81e-01	-1.50e-02	0.965000
DNA REPAIR	292	6.61e-01	-1.50e-02	0.878000
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	19	9.11e-01	-1.49e-02	0.977000
UNWINDING OF DNA	12	9.30e-01	1.47e-02	0.990000
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	8.84e-01	-1.45e-02	0.965000
SLC TRANSPORTER DISORDERS	74	8.30e-01	-1.44e-02	0.947000
GROWTH HORMONE RECEPTOR SIGNALING	20	9.11e-01	1.44e-02	0.977000
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	364	6.41e-01	1.43e-02	0.869000
NUCLEAR ENVELOPE BREAKDOWN	49	8.63e-01	1.42e-02	0.959000
PRC2 METHYLATES HISTONES AND DNA	29	8.96e-01	-1.40e-02	0.972000
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	8.83e-01	-1.40e-02	0.965000
MYD88 INDEPENDENT TLR4 CASCADE	94	8.29e-01	-1.29e-02	0.947000
RHO GTPASE EFFECTORS	245	7.29e-01	1.29e-02	0.897000
BILE ACID AND BILE SALT METABOLISM	25	9.12e-01	1.27e-02	0.977000
NUCLEAR IMPORT OF REV PROTEIN	32	9.03e-01	-1.25e-02	0.975000
TRNA PROCESSING IN THE NUCLEUS	56	8.74e-01	-1.23e-02	0.962000
PROTEIN FOLDING	89	8.45e-01	1.20e-02	0.950000
REGULATION OF FZD BY UBIQUITINATION	19	9.29e-01	-1.19e-02	0.989000
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	9.50e-01	-1.08e-02	0.996000
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	8.84e-01	-1.06e-02	0.965000
POST TRANSLATIONAL PROTEIN MODIFICATION	1216	5.41e-01	-1.05e-02	0.811000
P75NTR REGULATES AXONOGENESIS	10	9.55e-01	1.02e-02	0.996000
AMINO ACIDS REGULATE MTORC1	51	9.02e-01	9.96e-03	0.975000
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	177	8.20e-01	-9.91e-03	0.947000
SIGNALING BY FGFR2 IIIA TM	19	9.41e-01	9.85e-03	0.995000
CITRIC ACID CYCLE TCA CYCLE	22	9.36e-01	-9.82e-03	0.994000
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	179	8.28e-01	9.40e-03	0.947000
ENDOGENOUS STEROLS	20	9.43e-01	-9.29e-03	0.995000
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	9.13e-01	-9.10e-03	0.977000
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	9.41e-01	8.97e-03	0.995000
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	9.52e-01	-8.92e-03	0.996000
HS GAG BIOSYNTHESIS	29	9.35e-01	-8.71e-03	0.994000
INTERLEUKIN 15 SIGNALING	12	9.59e-01	8.63e-03	0.996000
DUAL INCISION IN GG NER	41	9.26e-01	-8.34e-03	0.988000
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	9.66e-01	-7.42e-03	0.996000
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	9.66e-01	7.37e-03	0.996000
FGFR2 MUTANT RECEPTOR ACTIVATION	26	9.49e-01	-7.28e-03	0.996000
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	9.47e-01	7.22e-03	0.996000
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	9.69e-01	-7.15e-03	0.997000
REGULATION OF TP53 ACTIVITY	151	8.84e-01	6.91e-03	0.965000
WNT LIGAND BIOGENESIS AND TRAFFICKING	23	9.55e-01	6.78e-03	0.996000
SIGNALING BY FGFR	72	9.22e-01	-6.66e-03	0.985000
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	9.62e-01	-6.41e-03	0.996000
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	9.23e-01	6.32e-03	0.985000
SIGNALING BY FGFR2	62	9.34e-01	-6.12e-03	0.993000
SMOOTH MUSCLE CONTRACTION	33	9.52e-01	-6.11e-03	0.996000
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	9.71e-01	6.03e-03	0.997000
TELOMERE EXTENSION BY TELOMERASE	22	9.61e-01	5.97e-03	0.996000
MEIOTIC SYNAPSIS	40	9.48e-01	-5.93e-03	0.996000
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	9.73e-01	5.61e-03	0.997000
DNA DOUBLE STRAND BREAK REPAIR	137	9.12e-01	-5.50e-03	0.977000
VITAMIN B5 PANTOTHENATE METABOLISM	14	9.74e-01	-5.11e-03	0.997000
SIGNALING BY FGFR3	35	9.59e-01	4.97e-03	0.996000
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	9.67e-01	-4.81e-03	0.996000
GABA B RECEPTOR ACTIVATION	39	9.60e-01	-4.68e-03	0.996000
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	9.79e-01	4.67e-03	0.999000
SPHINGOLIPID METABOLISM	81	9.42e-01	-4.65e-03	0.995000
NEGATIVE REGULATION OF FGFR2 SIGNALING	27	9.67e-01	4.63e-03	0.996000
HEDGEHOG ON STATE	83	9.42e-01	4.61e-03	0.995000
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	9.80e-01	-4.53e-03	0.999000
MITOCHONDRIAL BIOGENESIS	92	9.40e-01	4.51e-03	0.995000
NEUROTRANSMITTER RELEASE CYCLE	47	9.59e-01	4.35e-03	0.996000
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	24	9.71e-01	4.30e-03	0.997000
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	65	9.54e-01	-4.18e-03	0.996000
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	9.74e-01	4.15e-03	0.997000
ROS AND RNS PRODUCTION IN PHAGOCYTES	28	9.70e-01	4.06e-03	0.997000
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	107	9.43e-01	-4.01e-03	0.995000
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	52	9.61e-01	-3.92e-03	0.996000
AURKA ACTIVATION BY TPX2	71	9.55e-01	-3.86e-03	0.996000
FORMATION OF RNA POL II ELONGATION COMPLEX	57	9.64e-01	3.44e-03	0.996000
DNA DOUBLE STRAND BREAK RESPONSE	52	9.67e-01	3.37e-03	0.996000
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	92	9.56e-01	3.32e-03	0.996000
ESTROGEN DEPENDENT GENE EXPRESSION	102	9.62e-01	-2.75e-03	0.996000
CILIUM ASSEMBLY	190	9.51e-01	-2.59e-03	0.996000
CELLULAR RESPONSE TO HEAT STRESS	96	9.66e-01	2.52e-03	0.996000
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	29	9.82e-01	2.38e-03	0.999000
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	60	9.75e-01	-2.38e-03	0.997000
RESOLUTION OF ABASIC SITES AP SITES	38	9.82e-01	-2.17e-03	0.999000
SIALIC ACID METABOLISM	32	9.85e-01	1.87e-03	0.999000
ACYL CHAIN REMODELLING OF PE	16	9.91e-01	-1.69e-03	0.999000
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	90	9.79e-01	-1.60e-03	0.999000
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	9.88e-01	-1.60e-03	0.999000
TELOMERE MAINTENANCE	78	9.81e-01	-1.54e-03	0.999000
DISEASES OF PROGRAMMED CELL DEATH	54	9.87e-01	1.32e-03	0.999000
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	9.95e-01	1.24e-03	0.999000
G ALPHA I SIGNALLING EVENTS	192	9.80e-01	-1.04e-03	0.999000
MET RECEPTOR RECYCLING	10	9.96e-01	8.64e-04	0.999000
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	9.95e-01	8.64e-04	0.999000
PYRIMIDINE CATABOLISM	10	9.97e-01	7.10e-04	0.999000
PCP CE PATHWAY	91	9.93e-01	5.61e-04	0.999000
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	9.96e-01	-4.30e-04	0.999000
MYOGENESIS	25	9.97e-01	3.88e-04	0.999000
ORGANELLE BIOGENESIS AND MAINTENANCE	282	9.94e-01	-2.66e-04	0.999000
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	9.98e-01	2.56e-04	0.999000
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	10	9.99e-01	2.49e-04	0.999000
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	9.99e-01	-2.47e-04	0.999000
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	9.98e-01	-1.92e-04	0.999000
TRANSCRIPTIONAL REGULATION BY MECP2	60	9.98e-01	-1.56e-04	0.999000
RHOU GTPASE CYCLE	33	9.99e-01	9.70e-05	0.999000
TRNA PROCESSING	105	9.99e-01	-4.53e-05	0.999000

Detailed Gene set reports

COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN
	164
set	COHESIN LOADING ONTO CHROMATIN
setSize	10
pANOVA	0.00353
s.dist	-0.533
p.adjustANOVA	0.0599

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Smc3	-7975
Rad21	-7731
Stag2	-7576
Pds5b	-6348
Wapl	-5873
Nipbl	-4859
Stag1	-4187
Pds5a	-3294
Smc1a	-3206
Mau2	8684

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Smc3	-7975
Rad21	-7731
Stag2	-7576
Pds5b	-6348
Wapl	-5873
Nipbl	-4859
Stag1	-4187
Pds5a	-3294
Smc1a	-3206
Mau2	8684

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
	1048
set	SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize	12
pANOVA	0.0014
s.dist	-0.533
p.adjustANOVA	0.0376

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Spcs2	-8035
Spcs3	-7896
Pcsk1	-7280
Dpp4	-7096
Spcs1	-5610
Sec11a	-3720
Sec11c	-3701
Tcf7l2	-2896
Ctnnb1	-2304
Pax6	-1837
Grp	-1325
Gng13	885

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Spcs2	-8035
Spcs3	-7896
Pcsk1	-7280
Dpp4	-7096
Spcs1	-5610
Sec11a	-3720
Sec11c	-3701
Tcf7l2	-2896
Ctnnb1	-2304
Pax6	-1837
Grp	-1325
Gng13	885

INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION
	438
set	INCRETIN SYNTHESIS SECRETION AND INACTIVATION
setSize	13
pANOVA	0.00118
s.dist	-0.52
p.adjustANOVA	0.0371

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Spcs2	-8035
Spcs3	-7896
Pcsk1	-7280
Dpp4	-7096
Spcs1	-5610
Sec11a	-3720
Sec11c	-3701
Tcf7l2	-2896
Isl1	-2805
Ctnnb1	-2304
Pax6	-1837
Grp	-1325
Gng13	885

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Spcs2	-8035
Spcs3	-7896
Pcsk1	-7280
Dpp4	-7096
Spcs1	-5610
Sec11a	-3720
Sec11c	-3701
Tcf7l2	-2896
Isl1	-2805
Ctnnb1	-2304
Pax6	-1837
Grp	-1325
Gng13	885

TERMINATION OF O GLYCAN BIOSYNTHESIS

TERMINATION OF O GLYCAN BIOSYNTHESIS
	1057
set	TERMINATION OF O GLYCAN BIOSYNTHESIS
setSize	11
pANOVA	0.00328
s.dist	0.512
p.adjustANOVA	0.059

Top enriched genes

Top 20 genes
GeneID	Gene Rank
St3gal3	8670
St6galnac2	8117
St6galnac4	7920
St3gal2	7108
St3gal1	4068
Muc6	4056
Muc3a	3708
St6galnac3	3380
Muc1	3351
St3gal4	2155
St6gal1	-2025

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
St3gal3	8670
St6galnac2	8117
St6galnac4	7920
St3gal2	7108
St3gal1	4068
Muc6	4056
Muc3a	3708
St6galnac3	3380
Muc1	3351
St3gal4	2155
St6gal1	-2025

POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
	725
set	POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize	17
pANOVA	0.000265
s.dist	0.511
p.adjustANOVA	0.0174

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb4a	8426
Tbcd	8184
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Arl2	6821
Tubb6	6795
Tuba1b	6068
Tubb2b	5525
Tuba4a	4512
Tuba1a	4381
Tbcb	3336
Tbcc	1422
Tuba8	1029
Tbce	-2728
Tbca	-6636

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb4a	8426
Tbcd	8184
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Arl2	6821
Tubb6	6795
Tuba1b	6068
Tubb2b	5525
Tuba4a	4512
Tuba1a	4381
Tbcb	3336
Tbcc	1422
Tuba8	1029
Tbce	-2728
Tbca	-6636

CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS
	191
set	CROSSLINKING OF COLLAGEN FIBRILS
setSize	15
pANOVA	0.000938
s.dist	0.493
p.adjustANOVA	0.0371

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Loxl1	8319
Loxl3	7717
Pxdn	7399
Pcolce	7369
Col4a2	6243
Col1a1	6218
Col4a1	5628
Bmp1	5233
Tll2	4748
Col4a5	4244
Col4a3	3817
Col1a2	2483
Col4a4	2367
Tll1	-2487
Loxl2	-2802

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Loxl1	8319
Loxl3	7717
Pxdn	7399
Pcolce	7369
Col4a2	6243
Col1a1	6218
Col4a1	5628
Bmp1	5233
Tll2	4748
Col4a5	4244
Col4a3	3817
Col1a2	2483
Col4a4	2367
Tll1	-2487
Loxl2	-2802

PROCESSING AND ACTIVATION OF SUMO

PROCESSING AND ACTIVATION OF SUMO
	737
set	PROCESSING AND ACTIVATION OF SUMO
setSize	10
pANOVA	0.00822
s.dist	-0.483
p.adjustANOVA	0.101

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sumo1	-7721
Sumo2	-7623
Rwdd3	-6507
Ube2i	-5461
Senp5	-4326
Senp2	-3570
Uba2	-3145
Sumo3	-1650
Sae1	-1012
Senp1	2877

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sumo1	-7721
Sumo2	-7623
Rwdd3	-6507
Ube2i	-5461
Senp5	-4326
Senp2	-3570
Uba2	-3145
Sumo3	-1650
Sae1	-1012
Senp1	2877

APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION
	66
set	APOPTOSIS INDUCED DNA FRAGMENTATION
setSize	10
pANOVA	0.00822
s.dist	-0.483
p.adjustANOVA	0.101

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hmgb1	-8015
H1f2	-7875
Kpna1	-7625
H1f0	-7431
Casp3	-7246
H1f4	-5952
Hmgb2	-5383
Kpnb1	-1861
Dffb	6070
Dffa	7184

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hmgb1	-8015
H1f2	-7875
Kpna1	-7625
H1f0	-7431
Casp3	-7246
H1f4	-5952
Hmgb2	-5383
Kpnb1	-1861
Dffb	6070
Dffa	7184

ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY
	35
set	ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize	10
pANOVA	0.0106
s.dist	0.467
p.adjustANOVA	0.111

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Adcy6	7918
Adcy4	7515
Adcy5	7263
Adcy1	6292
Adcy3	6229
Adcy9	3792
Gnal	2364
Adcy2	1762
Adcy7	502
Adcy8	-1560

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Adcy6	7918
Adcy4	7515
Adcy5	7263
Adcy1	6292
Adcy3	6229
Adcy9	3792
Gnal	2364
Adcy2	1762
Adcy7	502
Adcy8	-1560

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY

CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
	201
set	CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY
setSize	13
pANOVA	0.00373
s.dist	0.465
p.adjustANOVA	0.0623

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ercc2	8672
Ndor1	8403
Nubp1	7762
Mms19	7727
Ciao3	7622
Pold1	6075
Rtel1	5377
Nubp2	5000
Ciapin1	4423
Ciao2b	3942
Ciao1	1954
Brip1	-4788
Abcb7	-7698

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ercc2	8672
Ndor1	8403
Nubp1	7762
Mms19	7727
Ciao3	7622
Pold1	6075
Rtel1	5377
Nubp2	5000
Ciapin1	4423
Ciao2b	3942
Ciao1	1954
Brip1	-4788
Abcb7	-7698

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
	1131
set	TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize	13
pANOVA	0.00442
s.dist	0.456
p.adjustANOVA	0.0671

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb4a	8426
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Tubb6	6795
Tuba1b	6068
Tubb2b	5525
Tuba4a	4512
Tuba1a	4381
Tuba8	1029
Gja1	-6681
Gjb2	-7257

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb4a	8426
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Tubb6	6795
Tuba1b	6068
Tubb2b	5525
Tuba4a	4512
Tuba1a	4381
Tuba8	1029
Gja1	-6681
Gjb2	-7257

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
	1047
set	SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
setSize	12
pANOVA	0.00628
s.dist	-0.456
p.adjustANOVA	0.0864

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Spcs2	-8035
Spcs3	-7896
Pla2g7	-7315
Pcsk1	-7280
Igf1	-6925
Bche	-6191
Spcs1	-5610
Sec11a	-3720
Sec11c	-3701
Klf4	3048
Crhr2	3261
Ache	7345

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Spcs2	-8035
Spcs3	-7896
Pla2g7	-7315
Pcsk1	-7280
Igf1	-6925
Bche	-6191
Spcs1	-5610
Sec11a	-3720
Sec11c	-3701
Klf4	3048
Crhr2	3261
Ache	7345

CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
	125
set	CD28 DEPENDENT VAV1 PATHWAY
setSize	11
pANOVA	0.0114
s.dist	-0.441
p.adjustANOVA	0.112

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdc42	-8103
Pak3	-7922
Pak2	-6948
Pak1	-6892
Rac1	-4971
Cd86	-3468
Cd80	-2956
Grb2	-1158
Fyn	1077
Lck	1386
Vav1	1921

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdc42	-8103
Pak3	-7922
Pak2	-6948
Pak1	-6892
Rac1	-4971
Cd86	-3468
Cd80	-2956
Grb2	-1158
Fyn	1077
Lck	1386
Vav1	1921

ACTIVATION OF SMO

ACTIVATION OF SMO
	26
set	ACTIVATION OF SMO
setSize	16
pANOVA	0.0028
s.dist	0.432
p.adjustANOVA	0.0556

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Arrb2	8418
Evc2	8191
Smo	7824
Grk2	7676
Evc	7384
Gas8	7022
Iqce	6946
Boc	6790
Gas1	6495
Arrb1	4563
Cdon	2825
Ptch1	1788
Shh	-84
Kif3a	-1376
Efcab7	-5253
Csnk1a1	-6640

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Arrb2	8418
Evc2	8191
Smo	7824
Grk2	7676
Evc	7384
Gas8	7022
Iqce	6946
Boc	6790
Gas1	6495
Arrb1	4563
Cdon	2825
Ptch1	1788
Shh	-84
Kif3a	-1376
Efcab7	-5253
Csnk1a1	-6640

MITOTIC TELOPHASE CYTOKINESIS

MITOTIC TELOPHASE CYTOKINESIS
	579
set	MITOTIC TELOPHASE CYTOKINESIS
setSize	13
pANOVA	0.0112
s.dist	-0.406
p.adjustANOVA	0.112

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Smc3	-7975
Rad21	-7731
Stag2	-7576
Pds5b	-6348
Wapl	-5873
Nipbl	-4859
Stag1	-4187
Pds5a	-3294
Smc1a	-3206
Plk1	-584
Kif23	-564
Kif20a	2338
Mau2	8684

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Smc3	-7975
Rad21	-7731
Stag2	-7576
Pds5b	-6348
Wapl	-5873
Nipbl	-4859
Stag1	-4187
Pds5a	-3294
Smc1a	-3206
Plk1	-584
Kif23	-564
Kif20a	2338
Mau2	8684

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
	1029
set	SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize	29
pANOVA	0.000173
s.dist	-0.403
p.adjustANOVA	0.0145

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ube2k	-8033
Ube2e1	-7991
Ube2w	-7969
Ube2q2	-7842
Ube2d1	-7767
Ube2b	-7710
Ube2g1	-7701
Ube2e3	-7465
Ube2l3	-7446
Usp9x	-7190
Ube2a	-7021
Ube2d2a	-7010
Uba6	-6190
Uchl3	-5135
Ube2r2	-4376
Rps27a	-4180
Otulin	-3313
Usp7	-3157
Ube2h	-3004
Ube2t	-2663

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ube2k	-8033
Ube2e1	-7991
Ube2w	-7969
Ube2q2	-7842
Ube2d1	-7767
Ube2b	-7710
Ube2g1	-7701
Ube2e3	-7465
Ube2l3	-7446
Usp9x	-7190
Ube2a	-7021
Ube2d2a	-7010
Uba6	-6190
Uchl3	-5135
Ube2r2	-4376
Rps27a	-4180
Otulin	-3313
Usp7	-3157
Ube2h	-3004
Ube2t	-2663
Ube2s	515
Uba52	1260
Ube2z	2330
Cdc34	2968
Uba1	3197
Usp5	4890
Ubc	5007
Ubb	5655
Ube2g2	6406

MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
	537
set	MET ACTIVATES RAP1 AND RAC1
setSize	11
pANOVA	0.0226
s.dist	-0.397
p.adjustANOVA	0.165

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rap1a	-8158
Rap1b	-7890
Hgf	-5700
Met	-5187
Crk	-5173
Rac1	-4971
Crkl	-4466
Dock7	-2596
Grb2	-1158
Gab1	3019
Rapgef1	8297

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rap1a	-8158
Rap1b	-7890
Hgf	-5700
Met	-5187
Crk	-5173
Rac1	-4971
Crkl	-4466
Dock7	-2596
Grb2	-1158
Gab1	3019
Rapgef1	8297

REPRESSION OF WNT TARGET GENES

REPRESSION OF WNT TARGET GENES
	826
set	REPRESSION OF WNT TARGET GENES
setSize	14
pANOVA	0.0117
s.dist	0.389
p.adjustANOVA	0.114

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Axin2	7391
Tle1	7269
Ctbp2	6852
Tle2	6484
Ctbp1	6357
Myc	5785
Tle5	5579
Tcf7l1	5115
Tle3	4841
Hdac1	1596
Tcf7	-222
Lef1	-1906
Tle4	-2491
Tcf7l2	-2896

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Axin2	7391
Tle1	7269
Ctbp2	6852
Tle2	6484
Ctbp1	6357
Myc	5785
Tle5	5579
Tcf7l1	5115
Tle3	4841
Hdac1	1596
Tcf7	-222
Lef1	-1906
Tle4	-2491
Tcf7l2	-2896

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
	187
set	CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
setSize	11
pANOVA	0.0267
s.dist	-0.386
p.adjustANOVA	0.181

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Calm1	-7820
Prkacb	-7730
Creb1	-7577
Prkar1a	-7404
Prkar2b	-7026
Prkx	-4930
Prkar2a	-3055
Adcy8	-1560
Prkar1b	3391
Prkaca	4461
Adcy1	6292

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Calm1	-7820
Prkacb	-7730
Creb1	-7577
Prkar1a	-7404
Prkar2b	-7026
Prkx	-4930
Prkar2a	-3055
Adcy8	-1560
Prkar1b	3391
Prkaca	4461
Adcy1	6292

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
	146
set	CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize	10
pANOVA	0.0353
s.dist	-0.384
p.adjustANOVA	0.219

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ywhae	-7748
Ywhab	-7697
Ywhaz	-7567
Ywhaq	-7059
Chek2	-4908
Ywhah	-2677
Chek1	-2105
Wee1	-1047
Ywhag	4978
Sfn	5992

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ywhae	-7748
Ywhab	-7697
Ywhaz	-7567
Ywhaq	-7059
Chek2	-4908
Ywhah	-2677
Chek1	-2105
Wee1	-1047
Ywhag	4978
Sfn	5992

CELLULAR HEXOSE TRANSPORT

CELLULAR HEXOSE TRANSPORT
	136
set	CELLULAR HEXOSE TRANSPORT
setSize	11
pANOVA	0.0292
s.dist	0.38
p.adjustANOVA	0.193

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Slc2a6	8711
Slc2a8	8471
Slc2a1	6710
Slc50a1	6015
Slc2a10	3503
Slc45a3	2963
Mfsd4b1	2673
Slc2a4	1975
Slc2a9	178
Slc2a3	-969
Slc2a12	-2020

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Slc2a6	8711
Slc2a8	8471
Slc2a1	6710
Slc50a1	6015
Slc2a10	3503
Slc45a3	2963
Mfsd4b1	2673
Slc2a4	1975
Slc2a9	178
Slc2a3	-969
Slc2a12	-2020

ACTIVATION OF RAC1

ACTIVATION OF RAC1
	25
set	ACTIVATION OF RAC1
setSize	13
pANOVA	0.0182
s.dist	-0.378
p.adjustANOVA	0.144

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pak3	-7922
Pak5	-7375
Pak2	-6948
Pak1	-6892
Nck1	-6619
Slit2	-5867
Sos2	-5570
Sos1	-5298
Rac1	-4971
Robo1	1089
Pak6	3641
Nck2	6160
Pak4	8451

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pak3	-7922
Pak5	-7375
Pak2	-6948
Pak1	-6892
Nck1	-6619
Slit2	-5867
Sos2	-5570
Sos1	-5298
Rac1	-4971
Robo1	1089
Pak6	3641
Nck2	6160
Pak4	8451

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
	15
set	ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
setSize	20
pANOVA	0.00432
s.dist	0.369
p.adjustANOVA	0.0671

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb4a	8426
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Tubb6	6795
Mapt	6126
Tuba1b	6068
Tubb2b	5525
Camkk2	4771
Tuba4a	4512
Tuba1a	4381
Prkag1	3219
Prkab1	2678
Prkag2	2416
Prkab2	1960
Tuba8	1029
Prkaa2	-6371
Prkaa1	-6882
Calm1	-7820

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb4a	8426
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Tubb6	6795
Mapt	6126
Tuba1b	6068
Tubb2b	5525
Camkk2	4771
Tuba4a	4512
Tuba1a	4381
Prkag1	3219
Prkab1	2678
Prkag2	2416
Prkab2	1960
Tuba8	1029
Prkaa2	-6371
Prkaa1	-6882
Calm1	-7820

SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION

SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
	910
set	SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
setSize	14
pANOVA	0.0181
s.dist	0.365
p.adjustANOVA	0.144

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tln1	8369
Plxna3	8125
Fes	7854
Pip5k1c	7499
Plxna1	7478
Plxna4	4651
Rras	4494
Nrp1	3828
Plxna2	2464
Farp2	1725
Fyn	1077
Rnd1	146
Rac1	-4971
Sema3a	-5883

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tln1	8369
Plxna3	8125
Fes	7854
Pip5k1c	7499
Plxna1	7478
Plxna4	4651
Rras	4494
Nrp1	3828
Plxna2	2464
Farp2	1725
Fyn	1077
Rnd1	146
Rac1	-4971
Sema3a	-5883

SYNAPTIC ADHESION LIKE MOLECULES

SYNAPTIC ADHESION LIKE MOLECULES
	1027
set	SYNAPTIC ADHESION LIKE MOLECULES
setSize	21
pANOVA	0.00409
s.dist	0.362
p.adjustANOVA	0.0655

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Grin2c	8593
Ptprs	8558
Grin1	8455
Lrfn4	8314
Lrfn1	8214
Grin2d	8087
Ptprf	7604
Lrfn3	7511
Lrfn2	7292
Flot2	7222
Dlg4	6504
Flot1	4933
Gria1	3701
Dlg3	2900
Grin2b	1090
Grin2a	994
Ptprd	-3424
Gria4	-6481
Rtn3	-6487
Gria3	-6672

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Grin2c	8593
Ptprs	8558
Grin1	8455
Lrfn4	8314
Lrfn1	8214
Grin2d	8087
Ptprf	7604
Lrfn3	7511
Lrfn2	7292
Flot2	7222
Dlg4	6504
Flot1	4933
Gria1	3701
Dlg3	2900
Grin2b	1090
Grin2a	994
Ptprd	-3424
Gria4	-6481
Rtn3	-6487
Gria3	-6672
Dlg1	-7155

ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS

ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS
	74
set	ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS
setSize	35
pANOVA	0.000282
s.dist	0.355
p.adjustANOVA	0.0174

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Grin2c	8593
Grin1	8455
Tubb4a	8426
Grin2d	8087
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Lin7b	7432
Camk2b	7337
Tuba1c	7302
Actn2	7146
Tubb6	6795
Dlg4	6504
Kif17	6124
Tuba1b	6068
Camk2a	6018
Tubb2b	5525
Apba1	4876
Tuba4a	4512
Tuba1a	4381

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Grin2c	8593
Grin1	8455
Tubb4a	8426
Grin2d	8087
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Lin7b	7432
Camk2b	7337
Tuba1c	7302
Actn2	7146
Tubb6	6795
Dlg4	6504
Kif17	6124
Tuba1b	6068
Camk2a	6018
Tubb2b	5525
Apba1	4876
Tuba4a	4512
Tuba1a	4381
Nefl	3455
Dlg3	2900
Camk2g	1604
Grin2b	1090
Tuba8	1029
Grin2a	994
Nbea	511
Lrrc7	-100
Lin7a	-1366
Dlg2	-1832
Grin3a	-2172
Cask	-6477
Dlg1	-7155
Camk2d	-7443
Lin7c	-8023

FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES

FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES
	339
set	FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES
setSize	15
pANOVA	0.0187
s.dist	0.351
p.adjustANOVA	0.147

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Crebbp	7899
Stk11	7364
Nfyc	7279
Ddit3	7121
Bcl6	6400
Foxo4	5873
Nfya	4396
Bbc3	3848
Ep300	3623
Foxo3	1752
Pink1	1707
Cited2	-209
Bcl2l11	-592
Foxo1	-730
Nfyb	-7310

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Crebbp	7899
Stk11	7364
Nfyc	7279
Ddit3	7121
Bcl6	6400
Foxo4	5873
Nfya	4396
Bbc3	3848
Ep300	3623
Foxo3	1752
Pink1	1707
Cited2	-209
Bcl2l11	-592
Foxo1	-730
Nfyb	-7310

NRAGE SIGNALS DEATH THROUGH JNK

NRAGE SIGNALS DEATH THROUGH JNK
	644
set	NRAGE SIGNALS DEATH THROUGH JNK
setSize	55
pANOVA	8.3e-06
s.dist	0.347
p.adjustANOVA	0.00203

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Arhgef4	8389
Plekhg5	8269
Arhgef5	8152
Arhgef10	8077
Plekhg2	8068
Arhgef10l	7986
Prex1	7978
Arhgef18	7897
Arhgef17	7876
Fgd1	7825
Arhgef2	7575
Arhgef40	7503
Arhgef11	7382
Arhgef1	7381
Vav2	7349
Mcf2l	7328
Arhgef7	7299
Arhgef19	7277
Abr	7028
Obscn	7000

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Arhgef4	8389
Plekhg5	8269
Arhgef5	8152
Arhgef10	8077
Plekhg2	8068
Arhgef10l	7986
Prex1	7978
Arhgef18	7897
Arhgef17	7876
Fgd1	7825
Arhgef2	7575
Arhgef40	7503
Arhgef11	7382
Arhgef1	7381
Vav2	7349
Mcf2l	7328
Arhgef7	7299
Arhgef19	7277
Abr	7028
Obscn	7000
Bad	6794
Kalrn	6581
Akap13	5878
Fgd3	5765
Trio	5419
Itsn1	5046
Fgd2	4975
Ngf	4741
Rasgrf2	4405
Arhgef33	4147
Maged1	3608
Arhgef15	3369
Arhgef6	3352
Arhgef16	3105
Tiam1	2573
Arhgef12	2168
Vav1	1921
Ngef	1301
Aatf	824
Arhgef26	447
Arhgef37	377
Bcl2l11	-592
Tiam2	-863
Ngfr	-1288
Gna13	-1942
Arhgef3	-2877
Arhgef9	-3542
Vav3	-3612
Net1	-3835
Rac1	-4971
Sos1	-5298
Sos2	-5570
Mcf2	-6037
Fgd4	-6754
Mapk8	-7602

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
	1046
set	SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize	20
pANOVA	0.00728
s.dist	-0.347
p.adjustANOVA	0.098

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acsl4	-8101
Acsl3	-8077
Elovl4	-7452
Hsd17b12	-7247
Hacd3	-7168
Elovl7	-7035
Elovl5	-6104
Acsl5	-5532
Elovl2	-5409
Hacd1	-5151
Hacd2	-3847
Hacd4	-3353
Acsl1	-2953
Acsl6	-2702
Elovl6	-947
Acsf3	489
Tecr	4241
Acsbg1	7133
Elovl1	7465
Slc27a3	8499

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acsl4	-8101
Acsl3	-8077
Elovl4	-7452
Hsd17b12	-7247
Hacd3	-7168
Elovl7	-7035
Elovl5	-6104
Acsl5	-5532
Elovl2	-5409
Hacd1	-5151
Hacd2	-3847
Hacd4	-3353
Acsl1	-2953
Acsl6	-2702
Elovl6	-947
Acsf3	489
Tecr	4241
Acsbg1	7133
Elovl1	7465
Slc27a3	8499

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
	1
set	A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize	26
pANOVA	0.00232
s.dist	0.345
p.adjustANOVA	0.0497

Top enriched genes

Top 20 genes
GeneID	Gene Rank
B3gat1	8150
Bcan	7924
Xylt2	7494
Hspg2	7484
Agrn	7422
B3galt6	7400
Gpc1	7370
Gpc4	7127
Cspg4	6486
B3gat3	6049
Ncan	5816
Sdc3	5762
Bgn	5436
Gpc2	4209
Sdc4	3495
B4galt7	3220
Gpc6	2499
Cspg5	1965
B3gat2	1194
Vcan	694

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
B3gat1	8150
Bcan	7924
Xylt2	7494
Hspg2	7484
Agrn	7422
B3galt6	7400
Gpc1	7370
Gpc4	7127
Cspg4	6486
B3gat3	6049
Ncan	5816
Sdc3	5762
Bgn	5436
Gpc2	4209
Sdc4	3495
B4galt7	3220
Gpc6	2499
Cspg5	1965
B3gat2	1194
Vcan	694
Sdc1	-1455
Gpc3	-2330
Xylt1	-2808
Gpc5	-4617
Dcn	-5719
Sdc2	-7629

MATURATION OF NUCLEOPROTEIN

MATURATION OF NUCLEOPROTEIN
	529
set	MATURATION OF NUCLEOPROTEIN
setSize	10
pANOVA	0.0599
s.dist	-0.344
p.adjustANOVA	0.288

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sumo1	-7721
Ube2i	-5461
Gsk3b	-5344
Parp14	-4901
Parp9	-4764
Parp10	-1986
Parp4	-1382
Parp16	649
Parp6	1819
Parp8	2704

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sumo1	-7721
Ube2i	-5461
Gsk3b	-5344
Parp14	-4901
Parp9	-4764
Parp10	-1986
Parp4	-1382
Parp16	649
Parp6	1819
Parp8	2704

EARLY PHASE OF HIV LIFE CYCLE

EARLY PHASE OF HIV LIFE CYCLE
	274
set	EARLY PHASE OF HIV LIFE CYCLE
setSize	13
pANOVA	0.0338
s.dist	-0.34
p.adjustANOVA	0.214

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Psip1	-7883
Kpna1	-7625
Xrcc5	-7481
Xrcc4	-6723
Lig4	-5846
Ccr5	-5696
Ppia	-4904
Xrcc6	-2303
Fen1	-376
Banf1	1779
Cxcr4	2237
Lig1	4073
Hmga1	6846

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Psip1	-7883
Kpna1	-7625
Xrcc5	-7481
Xrcc4	-6723
Lig4	-5846
Ccr5	-5696
Ppia	-4904
Xrcc6	-2303
Fen1	-376
Banf1	1779
Cxcr4	2237
Lig1	4073
Hmga1	6846

SIGNALING BY FGFR4 IN DISEASE

SIGNALING BY FGFR4 IN DISEASE
	953
set	SIGNALING BY FGFR4 IN DISEASE
setSize	10
pANOVA	0.0656
s.dist	-0.336
p.adjustANOVA	0.306

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Kras	-8145
Nras	-7416
Pik3ca	-7221
Pik3r1	-6335
Frs2	-5382
Sos1	-5298
Grb2	-1158
Gab1	3019
Hras	4086
Plcg1	8089

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Kras	-8145
Nras	-7416
Pik3ca	-7221
Pik3r1	-6335
Frs2	-5382
Sos1	-5298
Grb2	-1158
Gab1	3019
Hras	4086
Plcg1	8089

PRE NOTCH PROCESSING IN GOLGI

PRE NOTCH PROCESSING IN GOLGI
	733
set	PRE NOTCH PROCESSING IN GOLGI
setSize	18
pANOVA	0.0139
s.dist	0.335
p.adjustANOVA	0.128

Top enriched genes

Top 20 genes
GeneID	Gene Rank
St3gal3	8670
Lfng	8472
Furin	8438
Notch3	8325
Notch1	8206
Rfng	8033
Notch4	7812
Notch2	6960
B4galt1	6162
Atp2a3	4830
Atp2a1	4134
St3gal4	2155
Mfng	659
Sel1l	-2323
Atp2a2	-3230
Tmed2	-6842
Rab6a	-6963
St3gal6	-7783

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
St3gal3	8670
Lfng	8472
Furin	8438
Notch3	8325
Notch1	8206
Rfng	8033
Notch4	7812
Notch2	6960
B4galt1	6162
Atp2a3	4830
Atp2a1	4134
St3gal4	2155
Mfng	659
Sel1l	-2323
Atp2a2	-3230
Tmed2	-6842
Rab6a	-6963
St3gal6	-7783

SIGNALING BY FGFR3 FUSIONS IN CANCER

SIGNALING BY FGFR3 FUSIONS IN CANCER
	951
set	SIGNALING BY FGFR3 FUSIONS IN CANCER
setSize	10
pANOVA	0.0699
s.dist	-0.331
p.adjustANOVA	0.31

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Kras	-8145
Nras	-7416
Pik3ca	-7221
Pik3r1	-6335
Frs2	-5382
Sos1	-5298
Grb2	-1158
Gab1	3019
Hras	4086
Fgfr3	8528

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Kras	-8145
Nras	-7416
Pik3ca	-7221
Pik3r1	-6335
Frs2	-5382
Sos1	-5298
Grb2	-1158
Gab1	3019
Hras	4086
Fgfr3	8528

E2F MEDIATED REGULATION OF DNA REPLICATION

E2F MEDIATED REGULATION OF DNA REPLICATION
	272
set	E2F MEDIATED REGULATION OF DNA REPLICATION
setSize	19
pANOVA	0.0137
s.dist	-0.327
p.adjustANOVA	0.128

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Orc2	-7525
Orc4	-7512
Rb1	-7076
Orc5	-7050
Ppp2cb	-6716
Orc3	-6566
Ppp2ca	-6103
Orc6	-6082
Prim2	-5680
Prim1	-3038
Ppp2r1b	-2845
Tfdp2	-1912
Pola1	-1352
Mcm8	-1037
E2f1	1562
Tfdp1	3785
Ppp2r1a	4452
Pola2	5123
Ppp2r3d	8204

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Orc2	-7525
Orc4	-7512
Rb1	-7076
Orc5	-7050
Ppp2cb	-6716
Orc3	-6566
Ppp2ca	-6103
Orc6	-6082
Prim2	-5680
Prim1	-3038
Ppp2r1b	-2845
Tfdp2	-1912
Pola1	-1352
Mcm8	-1037
E2f1	1562
Tfdp1	3785
Ppp2r1a	4452
Pola2	5123
Ppp2r3d	8204

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES

COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
	165
set	COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES
setSize	62
pANOVA	9.27e-06
s.dist	0.326
p.adjustANOVA	0.00203

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Plod3	8519
Serpinh1	8200
Plod1	7472
Pcolce	7369
Colgalt1	7237
P3h1	7211
Adamts14	7158
P3h3	7135
Col9a3	6401
Col4a2	6243
Col1a1	6218
P3h2	6188
P4ha2	6129
Col18a1	5921
Col26a1	5835
Col27a1	5750
Col4a1	5628
Col11a2	5366
Bmp1	5233
Col13a1	5068

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Plod3	8519
Serpinh1	8200
Plod1	7472
Pcolce	7369
Colgalt1	7237
P3h1	7211
Adamts14	7158
P3h3	7135
Col9a3	6401
Col4a2	6243
Col1a1	6218
P3h2	6188
P4ha2	6129
Col18a1	5921
Col26a1	5835
Col27a1	5750
Col4a1	5628
Col11a2	5366
Bmp1	5233
Col13a1	5068
Tll2	4748
Ppib	4723
Col2a1	4670
Col4a5	4244
Col12a1	4239
Col8a2	4121
Crtap	4108
P4ha3	4011
Col4a3	3817
Col20a1	3742
Col16a1	3722
Col11a1	3187
Col6a3	3166
Col7a1	2998
Adamts3	2781
Col1a2	2483
Col4a4	2367
Col22a1	2244
Col15a1	2147
Col9a2	2103
Adamts2	1999
Col19a1	1941
Col6a5	1503
Col5a2	1387
Col5a3	1113
Col6a1	1100
Col8a1	964
Col5a1	429
Pcolce2	-94
Col6a2	-508
Col6a6	-570
P4hb	-602
Col23a1	-927
P4ha1	-1043
Col24a1	-1374
Col9a1	-1542
Col25a1	-1602
Colgalt2	-1860
Col14a1	-1865
Tll1	-2487
Col3a1	-3831
Plod2	-5533

SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX

SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX
	1035
set	SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX
setSize	12
pANOVA	0.0523
s.dist	0.324
p.adjustANOVA	0.278

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mapkapk2	6591
Cyp4f14	6035
Ltc4s	5961
Abcc1	5855
Ggt5	5054
Cyp4f15	3833
Alox5ap	3477
Alox5	1484
Ggt1	1439
Cyp4f16	1016
Ptgr1	-2289
Lta4h	-2469

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mapkapk2	6591
Cyp4f14	6035
Ltc4s	5961
Abcc1	5855
Ggt5	5054
Cyp4f15	3833
Alox5ap	3477
Alox5	1484
Ggt1	1439
Cyp4f16	1016
Ptgr1	-2289
Lta4h	-2469

CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN

CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
	112
set	CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN
setSize	35
pANOVA	0.000983
s.dist	0.322
p.adjustANOVA	0.0371

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb4a	8426
Tpgs1	7987
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Ttll11	7542
Tuba1c	7302
Ttll3	7130
Ttll12	6965
Tubb6	6795
Agbl5	6653
Tuba1b	6068
Ttll8	5681
Ttll5	5549
Ttll1	5548
Vash1	5529
Tubb2b	5525
Ttll4	5094
Tuba4a	4512
Ttll9	4387

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb4a	8426
Tpgs1	7987
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Ttll11	7542
Tuba1c	7302
Ttll3	7130
Ttll12	6965
Tubb6	6795
Agbl5	6653
Tuba1b	6068
Ttll8	5681
Ttll5	5549
Ttll1	5548
Vash1	5529
Tubb2b	5525
Ttll4	5094
Tuba4a	4512
Ttll9	4387
Tuba1a	4381
Ttl	3394
Agbl2	1901
Ttll13	1856
Ttll6	1213
Tuba8	1029
Nicn1	-1701
Svbp	-2542
Agtpbp1	-2942
Lrrc49	-3371
Agbl4	-4441
Vash2	-5030
Tpgs2	-5646
Agbl3	-6881
Ttll7	-7006

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
	906
set	SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
setSize	23
pANOVA	0.00759
s.dist	0.322
p.adjustANOVA	0.0986

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Lemd2	8553
Tubb4a	8426
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Tubb6	6795
Tuba1b	6068
Cc2d1b	5969
Tubb2b	5525
Chmp4b	4930
Tuba4a	4512
Chmp6	4395
Tuba1a	4381
Chmp7	2981
Tuba8	1029
Chmp4c	76
Ist1	-208
Chmp2a	-791
Vps4a	-4072

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Lemd2	8553
Tubb4a	8426
Tubb2a	7827
Tubb3	7808
Tubb4b	7797
Tuba1c	7302
Tubb6	6795
Tuba1b	6068
Cc2d1b	5969
Tubb2b	5525
Chmp4b	4930
Tuba4a	4512
Chmp6	4395
Tuba1a	4381
Chmp7	2981
Tuba8	1029
Chmp4c	76
Ist1	-208
Chmp2a	-791
Vps4a	-4072
Chmp3	-6145
Chmp2b	-6778
Spast	-7828

NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
	641
set	NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize	20
pANOVA	0.013
s.dist	0.321
p.adjustANOVA	0.121

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Notch1	8206
Crebbp	7899
Notch4	7812
Notch2	6960
Kat2a	6302
Hes5	5449
Flt4	5339
Smad3	5298
Maml3	5073
Maml1	4946
Hes1	4487
Ep300	3623
Mamld1	2254
Maml2	1087
Acta2	926
Hey1	-424
Rbpj	-1287
Hey2	-2060
Kat2b	-5160
Snw1	-7225

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Notch1	8206
Crebbp	7899
Notch4	7812
Notch2	6960
Kat2a	6302
Hes5	5449
Flt4	5339
Smad3	5298
Maml3	5073
Maml1	4946
Hes1	4487
Ep300	3623
Mamld1	2254
Maml2	1087
Acta2	926
Hey1	-424
Rbpj	-1287
Hey2	-2060
Kat2b	-5160
Snw1	-7225

CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING
	189
set	CRMPS IN SEMA3A SIGNALING
setSize	16
pANOVA	0.0266
s.dist	0.32
p.adjustANOVA	0.181

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dpysl4	8303
Plxna3	8125
Fes	7854
Dpysl5	7679
Plxna1	7478
Crmp1	7168
Cdk5	6446
Plxna4	4651
Nrp1	3828
Plxna2	2464
Fyn	1077
Dpysl2	-162
Cdk5r1	-2886
Dpysl3	-3273
Gsk3b	-5344
Sema3a	-5883

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dpysl4	8303
Plxna3	8125
Fes	7854
Dpysl5	7679
Plxna1	7478
Crmp1	7168
Cdk5	6446
Plxna4	4651
Nrp1	3828
Plxna2	2464
Fyn	1077
Dpysl2	-162
Cdk5r1	-2886
Dpysl3	-3273
Gsk3b	-5344
Sema3a	-5883

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
	40
set	ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize	19
pANOVA	0.0172
s.dist	-0.316
p.adjustANOVA	0.143

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gng2	-7364
P2ry12	-7235
Gnai3	-6940
Gng12	-6675
Gnai1	-6664
Gnb4	-5923
Gng11	-5748
Gng10	-5647
Gnb1	-5213
Gng5	-4130
Gng4	-2590
Gng3	-1019
Gngt2	30
Gng8	857
Gng13	885
Gnb5	1614
Gng7	4537
Gnai2	4799
Gnb2	6805

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gng2	-7364
P2ry12	-7235
Gnai3	-6940
Gng12	-6675
Gnai1	-6664
Gnb4	-5923
Gng11	-5748
Gng10	-5647
Gnb1	-5213
Gng5	-4130
Gng4	-2590
Gng3	-1019
Gngt2	30
Gng8	857
Gng13	885
Gnb5	1614
Gng7	4537
Gnai2	4799
Gnb2	6805

NCAM1 INTERACTIONS

NCAM1 INTERACTIONS
	597
set	NCAM1 INTERACTIONS
setSize	40
pANOVA	0.000639
s.dist	0.312
p.adjustANOVA	0.0312

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cacna1h	8637
Agrn	7422
Cacnb3	7338
Nrtn	7283
Cacna1i	6696
Cacnb1	6624
Col9a3	6401
Col4a2	6243
Cacna1d	6208
Cacna1g	5824
Ncan	5816
Cntn2	5812
Cacna1c	5646
Col4a1	5628
Gfra4	5465
Col2a1	4670
St8sia2	4418
Col4a5	4244
Col4a3	3817
Gfra1	3238

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cacna1h	8637
Agrn	7422
Cacnb3	7338
Nrtn	7283
Cacna1i	6696
Cacnb1	6624
Col9a3	6401
Col4a2	6243
Cacna1d	6208
Cacna1g	5824
Ncan	5816
Cntn2	5812
Cacna1c	5646
Col4a1	5628
Gfra4	5465
Col2a1	4670
St8sia2	4418
Col4a5	4244
Col4a3	3817
Gfra1	3238
Col6a3	3166
Ncam1	3080
Artn	2834
Col4a4	2367
Gfra2	2134
Col9a2	2103
Cacna1s	1911
Col6a5	1503
Col5a2	1387
Col5a3	1113
Col6a1	1100
Col5a1	429
Cacnb2	65
Col6a2	-508
Col6a6	-570
Col9a1	-1542
Prnp	-3210
Col3a1	-3831
St8sia4	-7191
Cacnb4	-7877

PEXOPHAGY

PEXOPHAGY
	690
set	PEXOPHAGY
setSize	11
pANOVA	0.0802
s.dist	0.305
p.adjustANOVA	0.333

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Usp30	7412
Pex5	7015
Epas1	5775
Ubb	5655
Ubc	5007
Map1lc3b	4910
Sqstm1	1772
Uba52	1260
Atm	-1121
Nbr1	-2275
Rps27a	-4180

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Usp30	7412
Pex5	7015
Epas1	5775
Ubb	5655
Ubc	5007
Map1lc3b	4910
Sqstm1	1772
Uba52	1260
Atm	-1121
Nbr1	-2275
Rps27a	-4180

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
	822
set	REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
setSize	13
pANOVA	0.0575
s.dist	0.304
p.adjustANOVA	0.286

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Banp	8273
Ppp1r13b	7980
Trp73	7470
Akt1	7002
Ppp1r13l	6778
Zfp385a	6521
Trp53	5412
Akt2	2310
Pou4f1	-1631
Akt3	-1938
Trp53bp2	-2940
Trp63	-3963
Phf20	-4408

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Banp	8273
Ppp1r13b	7980
Trp73	7470
Akt1	7002
Ppp1r13l	6778
Zfp385a	6521
Trp53	5412
Akt2	2310
Pou4f1	-1631
Akt3	-1938
Trp53bp2	-2940
Trp63	-3963
Phf20	-4408

INSULIN PROCESSING

INSULIN PROCESSING
	452
set	INSULIN PROCESSING
setSize	24
pANOVA	0.0099
s.dist	-0.304
p.adjustANOVA	0.109

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Exoc5	-8010
Pcsk1	-7280
Exoc6	-7180
Kif5b	-6789
Ero1a	-6533
Exoc2	-6109
Kif5c	-5854
Ero1b	-5811
Slc30a5	-5549
Cpe	-5245
Exoc3	-4703
Myo5a	-3776
Slc30a7	-3659
Vamp2	-2508
Pcsk2	-1769
Exoc1	-1445
Slc30a6	345
Stx1a	2182
Exoc4	2219
Kif5a	2288

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Exoc5	-8010
Pcsk1	-7280
Exoc6	-7180
Kif5b	-6789
Ero1a	-6533
Exoc2	-6109
Kif5c	-5854
Ero1b	-5811
Slc30a5	-5549
Cpe	-5245
Exoc3	-4703
Myo5a	-3776
Slc30a7	-3659
Vamp2	-2508
Pcsk2	-1769
Exoc1	-1445
Slc30a6	345
Stx1a	2182
Exoc4	2219
Kif5a	2288
Exoc8	2444
Rab27a	3706
Myrip	6423
Exoc7	7331

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
	735
set	PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
setSize	11
pANOVA	0.0823
s.dist	0.303
p.adjustANOVA	0.337

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cacna1a	7945
Cacnb3	7338
Cacng4	6639
Cacnb1	6624
Cacna1b	6418
Cacna2d2	2588
Cacna1e	1062
Cacng2	315
Cacnb2	65
Cacna2d3	-77
Cacnb4	-7877

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cacna1a	7945
Cacnb3	7338
Cacng4	6639
Cacnb1	6624
Cacna1b	6418
Cacna2d2	2588
Cacna1e	1062
Cacng2	315
Cacnb2	65
Cacna2d3	-77
Cacnb4	-7877

G BETA GAMMA SIGNALLING THROUGH CDC42

G BETA GAMMA SIGNALLING THROUGH CDC42
	351
set	G BETA GAMMA SIGNALLING THROUGH CDC42
setSize	18
pANOVA	0.0263
s.dist	-0.303
p.adjustANOVA	0.181

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cdc42	-8103
Gng2	-7364
Pak1	-6892
Gng12	-6675
Gnb4	-5923
Gng11	-5748
Gng10	-5647
Gnb1	-5213
Gng5	-4130
Gng4	-2590
Gng3	-1019
Gngt2	30
Gng8	857
Gng13	885
Gnb5	1614
Arhgef6	3352
Gng7	4537
Gnb2	6805

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cdc42	-8103
Gng2	-7364
Pak1	-6892
Gng12	-6675
Gnb4	-5923
Gng11	-5748
Gng10	-5647
Gnb1	-5213
Gng5	-4130
Gng4	-2590
Gng3	-1019
Gngt2	30
Gng8	857
Gng13	885
Gnb5	1614
Arhgef6	3352
Gng7	4537
Gnb2	6805

NF KB IS ACTIVATED AND SIGNALS SURVIVAL

NF KB IS ACTIVATED AND SIGNALS SURVIVAL
	624
set	NF KB IS ACTIVATED AND SIGNALS SURVIVAL
setSize	13
pANOVA	0.0591
s.dist	0.302
p.adjustANOVA	0.288

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ikbkb	7710
Rela	7692
Irak1	6187
Ubb	5655
Ubc	5007
Ngf	4741
Nfkb1	4060
Sqstm1	1772
Uba52	1260
Nfkbia	-111
Ngfr	-1288
Traf6	-1853
Rps27a	-4180

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ikbkb	7710
Rela	7692
Irak1	6187
Ubb	5655
Ubc	5007
Ngf	4741
Nfkb1	4060
Sqstm1	1772
Uba52	1260
Nfkbia	-111
Ngfr	-1288
Traf6	-1853
Rps27a	-4180

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports