date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik -2.2697336
0610009E02Rik -0.3519839
0610009L18Rik -0.9139963
0610010K14Rik -0.1751685
0610012G03Rik 0.5678859
0610030E20Rik 1.4359134

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16937
duplicated_genes_present 0
num_profile_genes_in_sets 8287
num_profile_genes_not_in_sets 8650

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 433
num_genesets_included 1171

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

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## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 8.74e-05 -0.654 9.59e-04
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 5.27e-05 -0.648 6.23e-04
EUKARYOTIC TRANSLATION ELONGATION 87 1.86e-20 -0.575 4.36e-18
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 8.89e-08 -0.555 2.57e-06
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.92e-13 -0.553 1.25e-11
EUKARYOTIC TRANSLATION INITIATION 114 3.62e-24 -0.549 2.12e-21
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 4.81e-22 -0.542 1.45e-19
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 2.31e-19 -0.537 3.86e-17
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 1.55e-03 -0.528 1.19e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.91e-03 0.514 3.02e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.40e-06 -0.498 5.85e-05
COMPLEX I BIOGENESIS 56 1.50e-10 -0.495 8.35e-09
CD28 DEPENDENT VAV1 PATHWAY 11 4.94e-03 -0.489 3.03e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 7.48e-03 0.488 4.21e-02
CRMPS IN SEMA3A SIGNALING 16 7.19e-04 0.488 6.33e-03
SELENOAMINO ACID METABOLISM 109 2.85e-18 -0.483 3.71e-16
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.03e-03 -0.477 4.85e-02
PROTEIN METHYLATION 17 7.85e-04 -0.470 6.81e-03
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.39e-03 -0.459 4.61e-02
RESPIRATORY ELECTRON TRANSPORT 102 1.34e-15 -0.458 1.21e-13
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 5.94e-04 -0.455 5.31e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.38e-02 0.450 6.84e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.79e-03 0.447 2.49e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.43e-03 0.447 1.12e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 1.20e-07 -0.446 3.28e-06
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.46e-08 -0.446 5.50e-07
NONSENSE MEDIATED DECAY NMD 109 9.02e-16 -0.446 9.49e-14
TRIGLYCERIDE CATABOLISM 14 4.25e-03 -0.441 2.75e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 4.97e-22 -0.441 1.45e-19
CRISTAE FORMATION 31 2.30e-05 -0.439 3.06e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.82e-17 -0.438 3.30e-15
NRAGE SIGNALS DEATH THROUGH JNK 55 2.09e-08 0.437 7.63e-07
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 6.58e-09 -0.437 2.85e-07
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 8.00e-09 -0.434 3.23e-07
SIGNALING BY LEPTIN 10 1.78e-02 0.433 8.24e-02
INTERLEUKIN 12 SIGNALING 37 5.34e-06 -0.432 8.61e-05
PROCESSING OF SMDT1 16 2.91e-03 -0.430 2.02e-02
GLYCOGEN SYNTHESIS 14 5.60e-03 -0.428 3.33e-02
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 7.14e-08 -0.424 2.20e-06
TRANSLATION 286 7.33e-35 -0.423 8.59e-32
MITOCHONDRIAL TRANSLATION 93 1.81e-12 -0.423 1.11e-10
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.91e-03 -0.423 1.40e-02
METABOLISM OF POLYAMINES 58 3.07e-08 -0.420 1.06e-06
SYNAPTIC ADHESION LIKE MOLECULES 21 8.84e-04 0.419 7.50e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.51e-04 -0.415 2.44e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.37e-02 -0.413 1.04e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.46e-03 -0.412 1.75e-02
ACTIVATION OF SMO 16 4.72e-03 0.408 2.96e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.88e-20 -0.408 5.63e-18
CROSSLINKING OF COLLAGEN FIBRILS 15 6.47e-03 0.406 3.68e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 8.74e-05 -0.654000 9.59e-04
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 5.27e-05 -0.648000 6.23e-04
EUKARYOTIC TRANSLATION ELONGATION 87 1.86e-20 -0.575000 4.36e-18
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 8.89e-08 -0.555000 2.57e-06
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.92e-13 -0.553000 1.25e-11
EUKARYOTIC TRANSLATION INITIATION 114 3.62e-24 -0.549000 2.12e-21
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 4.81e-22 -0.542000 1.45e-19
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 94 2.31e-19 -0.537000 3.86e-17
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 1.55e-03 -0.528000 1.19e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 4.91e-03 0.514000 3.02e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.40e-06 -0.498000 5.85e-05
COMPLEX I BIOGENESIS 56 1.50e-10 -0.495000 8.35e-09
CD28 DEPENDENT VAV1 PATHWAY 11 4.94e-03 -0.489000 3.03e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 7.48e-03 0.488000 4.21e-02
CRMPS IN SEMA3A SIGNALING 16 7.19e-04 0.488000 6.33e-03
SELENOAMINO ACID METABOLISM 109 2.85e-18 -0.483000 3.71e-16
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.03e-03 -0.477000 4.85e-02
PROTEIN METHYLATION 17 7.85e-04 -0.470000 6.81e-03
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.39e-03 -0.459000 4.61e-02
RESPIRATORY ELECTRON TRANSPORT 102 1.34e-15 -0.458000 1.21e-13
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 5.94e-04 -0.455000 5.31e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.38e-02 0.450000 6.84e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 3.79e-03 0.447000 2.49e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.43e-03 0.447000 1.12e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 1.20e-07 -0.446000 3.28e-06
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.46e-08 -0.446000 5.50e-07
NONSENSE MEDIATED DECAY NMD 109 9.02e-16 -0.446000 9.49e-14
TRIGLYCERIDE CATABOLISM 14 4.25e-03 -0.441000 2.75e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 4.97e-22 -0.441000 1.45e-19
CRISTAE FORMATION 31 2.30e-05 -0.439000 3.06e-04
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.82e-17 -0.438000 3.30e-15
NRAGE SIGNALS DEATH THROUGH JNK 55 2.09e-08 0.437000 7.63e-07
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 6.58e-09 -0.437000 2.85e-07
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 8.00e-09 -0.434000 3.23e-07
SIGNALING BY LEPTIN 10 1.78e-02 0.433000 8.24e-02
INTERLEUKIN 12 SIGNALING 37 5.34e-06 -0.432000 8.61e-05
PROCESSING OF SMDT1 16 2.91e-03 -0.430000 2.02e-02
GLYCOGEN SYNTHESIS 14 5.60e-03 -0.428000 3.33e-02
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 7.14e-08 -0.424000 2.20e-06
TRANSLATION 286 7.33e-35 -0.423000 8.59e-32
MITOCHONDRIAL TRANSLATION 93 1.81e-12 -0.423000 1.11e-10
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.91e-03 -0.423000 1.40e-02
METABOLISM OF POLYAMINES 58 3.07e-08 -0.420000 1.06e-06
SYNAPTIC ADHESION LIKE MOLECULES 21 8.84e-04 0.419000 7.50e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.51e-04 -0.415000 2.44e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.37e-02 -0.413000 1.04e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.46e-03 -0.412000 1.75e-02
ACTIVATION OF SMO 16 4.72e-03 0.408000 2.96e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.88e-20 -0.408000 5.63e-18
CROSSLINKING OF COLLAGEN FIBRILS 15 6.47e-03 0.406000 3.68e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 2.16e-02 -0.400000 9.56e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 2.62e-04 0.399000 2.54e-03
INTERACTION BETWEEN L1 AND ANKYRINS 27 3.41e-04 0.398000 3.17e-03
RORA ACTIVATES GENE EXPRESSION 18 3.48e-03 0.398000 2.33e-02
STABILIZATION OF P53 55 3.34e-07 -0.398000 7.39e-06
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 6.05e-03 -0.396000 3.52e-02
TRANSLESION SYNTHESIS BY POLH 19 2.91e-03 -0.394000 2.02e-02
METHYLATION 11 2.51e-02 -0.390000 1.09e-01
PYRUVATE METABOLISM 27 4.60e-04 -0.390000 4.21e-03
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 1.00e-06 -0.388000 1.95e-05
INTERLEUKIN 37 SIGNALING 17 5.56e-03 0.388000 3.32e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 1.54e-02 0.388000 7.40e-02
EARLY PHASE OF HIV LIFE CYCLE 13 1.54e-02 -0.388000 7.40e-02
NCAM1 INTERACTIONS 40 2.21e-05 0.388000 3.01e-04
TRANSLESION SYNTHESIS BY POLK 17 6.24e-03 -0.383000 3.62e-02
RUNX3 REGULATES NOTCH SIGNALING 13 1.77e-02 0.380000 8.24e-02
CELLULAR RESPONSE TO STARVATION 145 4.52e-15 -0.377000 3.53e-13
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 1.64e-07 -0.376000 4.08e-06
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 14 1.50e-02 0.375000 7.33e-02
CHOLESTEROL BIOSYNTHESIS 24 1.48e-03 -0.375000 1.15e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 9.76e-04 0.374000 8.04e-03
DEGRADATION OF DVL 56 1.33e-06 -0.374000 2.50e-05
IRAK4 DEFICIENCY TLR2 4 12 2.52e-02 -0.373000 1.09e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 64 2.47e-07 -0.373000 5.78e-06
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 2.11e-04 -0.373000 2.08e-03
ORC1 REMOVAL FROM CHROMATIN 68 1.24e-07 -0.371000 3.29e-06
INTERLEUKIN 12 FAMILY SIGNALING 44 2.37e-05 -0.368000 3.12e-04
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 3.92e-04 -0.368000 3.62e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 1.70e-04 -0.367000 1.72e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 3.55e-02 0.366000 1.42e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 10 4.57e-02 0.365000 1.66e-01
DEGRADATION OF AXIN 54 3.52e-06 -0.365000 5.97e-05
HEDGEHOG LIGAND BIOGENESIS 62 6.85e-07 -0.365000 1.39e-05
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 4.86e-03 0.364000 3.01e-02
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.36e-03 0.363000 1.07e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 1.53e-07 -0.363000 3.88e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 5.00e-03 -0.363000 3.05e-02
ANTIGEN PROCESSING CROSS PRESENTATION 94 1.30e-09 -0.362000 6.63e-08
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 6.47e-09 -0.360000 2.85e-07
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 70 1.94e-07 -0.360000 4.71e-06
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 6.56e-04 0.359000 5.82e-03
PROCESSING AND ACTIVATION OF SUMO 10 5.05e-02 -0.357000 1.77e-01
INTERLEUKIN 6 SIGNALING 10 5.11e-02 0.356000 1.79e-01
PENTOSE PHOSPHATE PATHWAY 13 2.62e-02 -0.356000 1.12e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 58 2.73e-06 -0.356000 4.78e-05
MITOCHONDRIAL PROTEIN IMPORT 63 1.02e-06 -0.356000 1.96e-05
INFLUENZA INFECTION 145 1.78e-13 -0.354000 1.22e-11
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.03e-03 0.354000 3.05e-02
REGULATION OF TLR BY ENDOGENOUS LIGAND 11 4.34e-02 -0.352000 1.61e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 1.69e-06 0.352000 3.05e-05
G1 S DNA DAMAGE CHECKPOINTS 66 8.58e-07 -0.350000 1.70e-05
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 5.91e-08 -0.349000 1.87e-06
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 3.68e-02 -0.348000 1.44e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 4.71e-03 -0.348000 2.96e-02
RRNA PROCESSING IN THE MITOCHONDRION 10 5.76e-02 -0.347000 1.97e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 2.03e-02 0.346000 9.10e-02
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 3.66e-03 -0.343000 2.42e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.66e-05 -0.340000 3.43e-04
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 1.46e-06 -0.338000 2.71e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 1.10e-02 -0.337000 5.79e-02
CELLULAR RESPONSE TO HYPOXIA 73 6.88e-07 -0.336000 1.39e-05
PROTEIN UBIQUITINATION 69 1.64e-06 -0.334000 3.01e-05
HDMS DEMETHYLATE HISTONES 27 2.69e-03 0.334000 1.89e-02
COLLAGEN CHAIN TRIMERIZATION 39 3.21e-04 0.333000 3.01e-03
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 8.49e-06 -0.332000 1.26e-04
CITRIC ACID CYCLE TCA CYCLE 22 7.30e-03 -0.330000 4.13e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.29e-02 -0.330000 6.49e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 4.28e-07 -0.329000 9.28e-06
PHOSPHORYLATION OF THE APC C 17 1.91e-02 -0.328000 8.74e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.45e-03 -0.328000 3.68e-02
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 4.05e-02 0.328000 1.55e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 4.11e-02 0.327000 1.56e-01
PRE NOTCH PROCESSING IN GOLGI 18 1.71e-02 0.325000 8.06e-02
CHAPERONE MEDIATED AUTOPHAGY 20 1.22e-02 -0.324000 6.24e-02
RHOBTB3 ATPASE CYCLE 10 7.63e-02 -0.324000 2.38e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 4.35e-02 0.323000 1.61e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 53 4.78e-05 0.323000 5.78e-04
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 1.04e-02 -0.323000 5.51e-02
DNA REPLICATION PRE INITIATION 80 6.74e-07 -0.321000 1.39e-05
SIGNALING BY ROBO RECEPTORS 206 2.94e-15 -0.319000 2.46e-13
RRNA PROCESSING 194 2.55e-14 -0.317000 1.87e-12
AMINE LIGAND BINDING RECEPTORS 29 3.17e-03 0.317000 2.17e-02
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 50 1.12e-04 -0.316000 1.17e-03
NEPHRIN FAMILY INTERACTIONS 22 1.04e-02 0.316000 5.50e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.48e-02 -0.315000 7.27e-02
CELLULAR HEXOSE TRANSPORT 11 7.26e-02 0.313000 2.30e-01
INSULIN RECEPTOR RECYCLING 20 1.69e-02 -0.309000 7.99e-02
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 4.32e-03 -0.306000 2.78e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.91e-02 0.306000 2.43e-01
PYROPTOSIS 21 1.54e-02 -0.305000 7.40e-02
REPRESSION OF WNT TARGET GENES 14 4.84e-02 0.305000 1.73e-01
REGULATION OF RAS BY GAPS 67 1.70e-05 -0.304000 2.37e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 5.81e-02 -0.304000 1.98e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.89e-02 -0.303000 8.66e-02
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 9.79e-02 0.302000 2.77e-01
LONG TERM POTENTIATION 23 1.22e-02 0.302000 6.24e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 5.56e-05 0.301000 6.45e-04
REGULATION OF BACH1 ACTIVITY 11 8.45e-02 -0.300000 2.53e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 11 8.47e-02 -0.300000 2.53e-01
DNA REPLICATION 122 1.12e-08 -0.300000 4.37e-07
REGULATION OF PTEN STABILITY AND ACTIVITY 67 2.44e-05 -0.298000 3.17e-04
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 37 1.71e-03 0.298000 1.28e-02
NEUREXINS AND NEUROLIGINS 54 1.53e-04 0.298000 1.55e-03
SYNTHESIS OF PE 13 6.36e-02 0.297000 2.11e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 5.08e-03 -0.296000 3.06e-02
COLLAGEN FORMATION 78 7.56e-06 0.293000 1.15e-04
METABOLISM OF AMINO ACIDS AND DERIVATIVES 316 4.08e-19 -0.293000 5.97e-17
INTERLEUKIN 20 FAMILY SIGNALING 13 6.80e-02 0.292000 2.20e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 4.07e-06 -0.291000 6.80e-05
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 5.13e-02 0.291000 1.79e-01
CDC42 GTPASE CYCLE 152 6.45e-10 0.291000 3.43e-08
RAS PROCESSING 24 1.40e-02 -0.290000 6.90e-02
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.79e-03 0.288000 2.98e-02
ABC TRANSPORTER DISORDERS 69 3.51e-05 -0.288000 4.41e-04
RHOB GTPASE CYCLE 67 4.79e-05 0.287000 5.78e-04
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 5.37e-06 -0.287000 8.61e-05
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 2.28e-05 0.287000 3.06e-04
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 1.00e-01 -0.286000 2.80e-01
FCERI MEDIATED NF KB ACTIVATION 77 1.74e-05 -0.283000 2.40e-04
LGI ADAM INTERACTIONS 14 6.73e-02 0.282000 2.19e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 6.85e-06 -0.282000 1.07e-04
BRANCHED CHAIN AMINO ACID CATABOLISM 21 2.57e-02 -0.281000 1.10e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 1.32e-02 0.281000 6.59e-02
PURINE CATABOLISM 16 5.19e-02 -0.281000 1.80e-01
INTERLEUKIN 6 FAMILY SIGNALING 19 3.48e-02 0.280000 1.40e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.37e-02 -0.279000 6.82e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 3.61e-02 -0.278000 1.43e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 4.18e-02 -0.277000 1.57e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 5.53e-04 0.277000 4.98e-03
PKMTS METHYLATE HISTONE LYSINES 48 9.45e-04 0.276000 7.91e-03
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 4.31e-02 0.275000 1.61e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 6.52e-02 -0.275000 2.15e-01
ENOS ACTIVATION 11 1.15e-01 -0.275000 3.10e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 8.76e-02 0.274000 2.59e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.98e-02 -0.272000 1.53e-01
METABOLISM OF COFACTORS 18 4.57e-02 -0.272000 1.66e-01
SCAVENGING BY CLASS A RECEPTORS 13 9.16e-02 -0.270000 2.64e-01
S PHASE 154 7.33e-09 -0.270000 3.06e-07
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.68e-05 0.270000 2.37e-04
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 1.21e-01 -0.270000 3.21e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.53e-02 -0.270000 7.40e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 1.21e-02 -0.269000 6.23e-02
FATTY ACYL COA BIOSYNTHESIS 32 8.43e-03 -0.269000 4.61e-02
REGULATED NECROSIS 46 1.76e-03 -0.267000 1.31e-02
TRP CHANNELS 18 5.25e-02 0.264000 1.82e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 37 5.75e-03 -0.262000 3.39e-02
IRON UPTAKE AND TRANSPORT 52 1.07e-03 -0.262000 8.75e-03
G ALPHA 12 13 SIGNALLING EVENTS 74 9.76e-05 0.262000 1.04e-03
PLATELET ADHESION TO EXPOSED COLLAGEN 11 1.34e-01 -0.261000 3.42e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 3.87e-02 0.261000 1.50e-01
G PROTEIN ACTIVATION 22 3.54e-02 -0.259000 1.41e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 8.02e-03 0.259000 4.47e-02
INTEGRIN SIGNALING 24 2.84e-02 0.259000 1.20e-01
SIGNALING BY FGFR4 IN DISEASE 10 1.57e-01 -0.258000 3.79e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 20 4.59e-02 -0.258000 1.66e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.59e-01 -0.258000 3.81e-01
G2 M CHECKPOINTS 135 2.57e-07 -0.257000 5.90e-06
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 4.69e-02 0.257000 1.68e-01
HSF1 ACTIVATION 25 2.65e-02 -0.256000 1.13e-01
PROTEIN LOCALIZATION 156 3.75e-08 -0.255000 1.25e-06
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.94e-02 -0.255000 8.82e-02
RET SIGNALING 36 8.24e-03 0.255000 4.57e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 1.29e-02 0.254000 6.49e-02
CELLULAR RESPONSE TO CHEMICAL STRESS 150 8.09e-08 -0.254000 2.43e-06
INOSITOL PHOSPHATE METABOLISM 47 2.64e-03 0.254000 1.86e-02
PHASE 2 PLATEAU PHASE 13 1.14e-01 0.253000 3.08e-01
MTORC1 MEDIATED SIGNALLING 24 3.16e-02 -0.253000 1.29e-01
PI METABOLISM 79 1.05e-04 0.252000 1.11e-03
PEPTIDE HORMONE METABOLISM 59 8.11e-04 -0.252000 6.94e-03
LAMININ INTERACTIONS 28 2.14e-02 0.251000 9.48e-02
COLLAGEN DEGRADATION 51 1.93e-03 0.251000 1.41e-02
REGULATION OF BETA CELL DEVELOPMENT 25 3.00e-02 0.251000 1.24e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 1.70e-01 0.251000 3.97e-01
O LINKED GLYCOSYLATION 87 5.45e-05 0.250000 6.39e-04
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 9.44e-02 0.249000 2.70e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 8.76e-05 -0.249000 9.59e-04
MITOPHAGY 29 2.03e-02 -0.249000 9.10e-02
VOLTAGE GATED POTASSIUM CHANNELS 40 6.46e-03 0.249000 3.68e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 9.67e-02 -0.248000 2.76e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 8.32e-03 0.247000 4.60e-02
TRAF6 MEDIATED IRF7 ACTIVATION 15 9.74e-02 0.247000 2.77e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 3.56e-05 0.247000 4.44e-04
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.39e-01 -0.246000 3.53e-01
RHOBTB2 GTPASE CYCLE 23 4.15e-02 -0.246000 1.57e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 7.13e-02 0.246000 2.28e-01
SEPARATION OF SISTER CHROMATIDS 165 5.40e-08 -0.246000 1.76e-06
MET ACTIVATES RAS SIGNALING 10 1.80e-01 -0.245000 4.14e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.00e-01 0.245000 2.80e-01
ACTIVATION OF RAC1 13 1.26e-01 -0.245000 3.28e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 1.82e-01 0.244000 4.14e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 1.28e-01 0.244000 3.33e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 86 9.60e-05 0.243000 1.03e-03
EFFECTS OF PIP2 HYDROLYSIS 27 2.99e-02 0.242000 1.24e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.39e-02 -0.240000 6.87e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.50e-01 -0.240000 3.70e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 7.89e-02 -0.239000 2.43e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 9.80e-02 0.239000 2.77e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 1.71e-01 0.238000 3.99e-01
SIGNALING BY THE B CELL RECEPTOR BCR 104 2.96e-05 -0.237000 3.77e-04
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 1.56e-01 -0.237000 3.77e-01
CALNEXIN CALRETICULIN CYCLE 26 3.68e-02 -0.237000 1.44e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 1.57e-01 -0.236000 3.79e-01
FORMATION OF APOPTOSOME 10 1.96e-01 -0.236000 4.32e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 1.24e-03 -0.235000 1.00e-02
PRE NOTCH EXPRESSION AND PROCESSING 64 1.15e-03 0.235000 9.32e-03
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.99e-01 -0.235000 4.35e-01
METABOLISM OF STEROID HORMONES 20 7.00e-02 -0.234000 2.25e-01
MET ACTIVATES RAP1 AND RAC1 11 1.80e-01 -0.234000 4.14e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.45e-01 -0.234000 3.62e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 4.33e-02 -0.234000 1.61e-01
IRE1ALPHA ACTIVATES CHAPERONES 49 4.70e-03 0.234000 2.96e-02
CARNITINE METABOLISM 14 1.30e-01 0.233000 3.37e-01
RAB GERANYLGERANYLATION 59 2.02e-03 -0.232000 1.47e-02
MITOTIC G1 PHASE AND G1 S TRANSITION 141 1.93e-06 -0.232000 3.43e-05
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.72e-02 -0.231000 2.19e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 2.66e-02 -0.230000 1.13e-01
CYTOPROTECTION BY HMOX1 120 1.40e-05 -0.230000 2.03e-04
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 1.52e-01 -0.229000 3.73e-01
ECM PROTEOGLYCANS 66 1.28e-03 0.229000 1.02e-02
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 1.52e-01 0.229000 3.73e-01
SHC MEDIATED CASCADE FGFR4 11 1.88e-01 -0.229000 4.23e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 8.44e-02 -0.229000 2.53e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 2.11e-01 -0.229000 4.51e-01
OLFACTORY SIGNALING PATHWAY 30 3.04e-02 -0.228000 1.25e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 3.04e-02 0.228000 1.25e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 2.56e-02 0.228000 1.10e-01
RAC1 GTPASE CYCLE 176 1.97e-07 0.228000 4.71e-06
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 1.92e-01 -0.227000 4.26e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 106 5.71e-05 0.226000 6.56e-04
CLEC7A DECTIN 1 SIGNALING 95 1.40e-04 -0.226000 1.45e-03
TERMINATION OF TRANSLESION DNA SYNTHESIS 31 3.01e-02 -0.225000 1.25e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 14 1.45e-01 -0.225000 3.62e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 3.97e-02 -0.225000 1.53e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 5.81e-02 -0.223000 1.98e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 51 5.98e-03 0.223000 3.50e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 4.96e-02 0.222000 1.75e-01
CELL CYCLE CHECKPOINTS 243 2.89e-09 -0.221000 1.35e-07
TNFR2 NON CANONICAL NF KB PATHWAY 83 4.98e-04 -0.221000 4.52e-03
INACTIVATION OF CSF3 G CSF SIGNALING 24 6.19e-02 -0.220000 2.07e-01
O LINKED GLYCOSYLATION OF MUCINS 40 1.67e-02 0.219000 7.95e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 2.71e-04 -0.219000 2.60e-03
TRANSCRIPTIONAL REGULATION BY RUNX2 111 7.60e-05 -0.218000 8.56e-04
ERBB2 ACTIVATES PTK6 SIGNALING 10 2.34e-01 0.217000 4.80e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.78e-02 -0.217000 8.24e-02
DEATH RECEPTOR SIGNALLING 133 1.65e-05 0.216000 2.35e-04
CYTOSOLIC TRNA AMINOACYLATION 24 6.64e-02 -0.216000 2.17e-01
C TYPE LECTIN RECEPTORS CLRS 113 7.22e-05 -0.216000 8.21e-04
TIE2 SIGNALING 17 1.23e-01 -0.216000 3.24e-01
DAG AND IP3 SIGNALING 40 1.84e-02 0.215000 8.49e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 23 7.40e-02 -0.215000 2.34e-01
NETRIN 1 SIGNALING 48 1.01e-02 0.215000 5.39e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 50 8.72e-03 0.214000 4.72e-02
GAP JUNCTION ASSEMBLY 22 8.19e-02 -0.214000 2.50e-01
HOST INTERACTIONS OF HIV FACTORS 124 3.90e-05 -0.214000 4.81e-04
RHOC GTPASE CYCLE 73 1.63e-03 0.213000 1.23e-02
PROGRAMMED CELL DEATH 187 5.07e-07 -0.213000 1.08e-05
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 1.18e-01 0.213000 3.15e-01
P75NTR REGULATES AXONOGENESIS 10 2.45e-01 -0.212000 4.88e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 6.17e-02 0.212000 2.07e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.04e-01 0.212000 4.42e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.11e-01 -0.211000 3.02e-01
SIGNALING BY NOTCH1 75 1.62e-03 0.211000 1.23e-02
CHROMATIN MODIFYING ENZYMES 218 9.00e-08 0.210000 2.57e-06
GAP JUNCTION DEGRADATION 11 2.30e-01 -0.209000 4.76e-01
RHOBTB1 GTPASE CYCLE 23 8.29e-02 -0.209000 2.52e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 2.30e-01 0.209000 4.76e-01
TCR SIGNALING 101 2.96e-04 -0.208000 2.80e-03
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 1.63e-01 0.208000 3.83e-01
SMOOTH MUSCLE CONTRACTION 33 3.91e-02 -0.208000 1.51e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.08e-01 0.207000 2.96e-01
MITOTIC METAPHASE AND ANAPHASE 206 2.97e-07 -0.207000 6.69e-06
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 30 4.95e-02 0.207000 1.75e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 2.14e-01 -0.207000 4.52e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 9.36e-02 0.207000 2.69e-01
GP1B IX V ACTIVATION SIGNALLING 10 2.60e-01 0.206000 5.02e-01
GLYCOGEN METABOLISM 25 7.52e-02 -0.206000 2.35e-01
G2 M DNA DAMAGE CHECKPOINT 65 4.23e-03 -0.205000 2.75e-02
FC EPSILON RECEPTOR FCERI SIGNALING 124 8.10e-05 -0.205000 9.03e-04
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 2.19e-01 0.205000 4.58e-01
PHASE II CONJUGATION OF COMPOUNDS 61 5.68e-03 -0.205000 3.36e-02
APOPTOSIS 165 6.54e-06 -0.204000 1.04e-04
ANCHORING FIBRIL FORMATION 14 1.87e-01 0.203000 4.23e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 9.14e-02 -0.203000 2.64e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 2.44e-01 0.203000 4.88e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 7.49e-02 -0.202000 2.35e-01
MEIOTIC RECOMBINATION 38 3.19e-02 -0.201000 1.30e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.12e-01 -0.200000 3.05e-01
GLUCAGON TYPE LIGAND RECEPTORS 25 8.34e-02 -0.200000 2.52e-01
INTRA GOLGI TRAFFIC 43 2.33e-02 0.200000 1.02e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 2.31e-01 -0.200000 4.76e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 1.96e-01 0.199000 4.32e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.74e-02 -0.198000 8.20e-02
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 4.54e-02 -0.198000 1.66e-01
STIMULI SENSING CHANNELS 74 3.24e-03 0.198000 2.18e-02
EXTRACELLULAR MATRIX ORGANIZATION 240 1.41e-07 0.197000 3.68e-06
PHASE 0 RAPID DEPOLARISATION 29 6.63e-02 0.197000 2.17e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 9.02e-02 -0.196000 2.62e-01
SIGNALING BY NOTCH4 83 2.10e-03 -0.195000 1.52e-02
DNA DAMAGE BYPASS 47 2.11e-02 -0.195000 9.38e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 2.90e-01 -0.193000 5.28e-01
LAGGING STRAND SYNTHESIS 20 1.35e-01 -0.193000 3.44e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 2.68e-01 0.193000 5.11e-01
UCH PROTEINASES 90 1.57e-03 -0.193000 1.20e-02
NUCLEAR IMPORT OF REV PROTEIN 32 5.96e-02 0.192000 2.02e-01
MAPK6 MAPK4 SIGNALING 84 2.32e-03 -0.192000 1.66e-02
PLATELET AGGREGATION PLUG FORMATION 32 6.03e-02 0.192000 2.03e-01
PHOSPHOLIPID METABOLISM 185 7.07e-06 0.192000 1.09e-04
GLYCOGEN STORAGE DISEASES 12 2.53e-01 -0.191000 4.94e-01
KILLING MECHANISMS 10 2.97e-01 0.190000 5.36e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 8.84e-02 0.189000 2.59e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 38 4.37e-02 -0.189000 1.61e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 1.54e-01 -0.189000 3.76e-01
REGULATION OF IFNG SIGNALING 13 2.38e-01 -0.189000 4.84e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.63e-02 0.189000 1.44e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.18e-01 0.188000 3.16e-01
TRANSCRIPTIONAL REGULATION BY MECP2 60 1.19e-02 0.188000 6.20e-02
SIGNALING BY NOTCH2 33 6.26e-02 0.187000 2.08e-01
TRIGLYCERIDE METABOLISM 23 1.20e-01 -0.187000 3.19e-01
BIOTIN TRANSPORT AND METABOLISM 11 2.83e-01 0.187000 5.24e-01
RMTS METHYLATE HISTONE ARGININES 43 3.41e-02 0.187000 1.38e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.97e-01 0.187000 4.32e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 5.00e-02 0.186000 1.76e-01
METABOLISM OF RNA 644 9.73e-16 -0.186000 9.49e-14
MET ACTIVATES PTK2 SIGNALING 29 8.31e-02 0.186000 2.52e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 1.23e-01 0.186000 3.24e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 2.87e-01 0.186000 5.26e-01
RHO GTPASES ACTIVATE KTN1 11 2.87e-01 -0.185000 5.26e-01
MRNA SPLICING 188 1.23e-05 -0.185000 1.80e-04
RHOA GTPASE CYCLE 141 1.52e-04 0.185000 1.55e-03
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 1.35e-01 -0.184000 3.44e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 2.18e-01 0.184000 4.57e-01
RHOBTB GTPASE CYCLE 35 6.01e-02 -0.184000 2.03e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.95e-01 0.182000 5.33e-01
INTERLEUKIN 15 SIGNALING 12 2.75e-01 0.182000 5.17e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 1.60e-01 0.181000 3.83e-01
DARPP 32 EVENTS 23 1.32e-01 -0.181000 3.39e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 8.10e-02 0.181000 2.48e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 3.22e-01 0.181000 5.62e-01
REGULATED PROTEOLYSIS OF P75NTR 12 2.80e-01 0.180000 5.21e-01
DSCAM INTERACTIONS 10 3.25e-01 0.180000 5.64e-01
SIGNALING BY FGFR2 IN DISEASE 36 6.22e-02 -0.180000 2.08e-01
POLYMERASE SWITCHING 14 2.45e-01 -0.179000 4.88e-01
SHC1 EVENTS IN EGFR SIGNALING 10 3.27e-01 -0.179000 5.67e-01
FATTY ACID METABOLISM 145 2.10e-04 -0.178000 2.08e-03
SIGNALING BY NOTCH3 48 3.27e-02 0.178000 1.32e-01
SIGNALING BY CSF3 G CSF 29 9.80e-02 -0.178000 2.77e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 2.50e-01 0.178000 4.92e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 2.36e-01 -0.177000 4.83e-01
INWARDLY RECTIFYING K CHANNELS 31 8.86e-02 -0.177000 2.59e-01
RHO GTPASES ACTIVATE PKNS 47 3.68e-02 -0.176000 1.44e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 1.97e-01 0.176000 4.32e-01
MITOTIC SPINDLE CHECKPOINT 96 2.99e-03 -0.175000 2.06e-02
HIV INFECTION 220 7.94e-06 -0.175000 1.19e-04
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 2.04e-02 0.175000 9.14e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 1.04e-01 0.174000 2.87e-01
FRS MEDIATED FGFR4 SIGNALING 13 2.76e-01 -0.174000 5.18e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 8.84e-02 -0.174000 2.59e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 6.87e-02 0.173000 2.22e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 1.19e-02 -0.173000 6.20e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.82e-01 0.173000 4.14e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 3.46e-01 0.172000 5.87e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 24 1.45e-01 -0.172000 3.62e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 92 4.43e-03 -0.172000 2.84e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 1.55e-01 -0.172000 3.77e-01
ION TRANSPORT BY P TYPE ATPASES 48 4.00e-02 0.171000 1.53e-01
RHOU GTPASE CYCLE 33 8.87e-02 0.171000 2.59e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.55e-01 -0.171000 3.77e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 8.46e-02 0.171000 2.53e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 16 2.37e-01 -0.171000 4.84e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 1.65e-01 -0.171000 3.87e-01
SIGNAL AMPLIFICATION 30 1.06e-01 -0.171000 2.90e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.34e-02 -0.171000 1.03e-01
HIV TRANSCRIPTION INITIATION 45 4.77e-02 -0.171000 1.71e-01
DISEASES OF GLYCOSYLATION 126 9.75e-04 0.170000 8.04e-03
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 1.26e-01 0.170000 3.28e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 1.60e-01 0.169000 3.83e-01
FGFR2 LIGAND BINDING AND ACTIVATION 11 3.31e-01 -0.169000 5.72e-01
RNA POLYMERASE III CHAIN ELONGATION 18 2.14e-01 -0.169000 4.52e-01
GLUTATHIONE CONJUGATION 29 1.15e-01 -0.169000 3.10e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 598 3.12e-12 -0.167000 1.83e-10
NEUTROPHIL DEGRANULATION 384 2.31e-08 -0.166000 8.19e-07
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 1.58e-01 -0.166000 3.81e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 3.02e-01 -0.166000 5.39e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 3.18e-03 0.165000 2.17e-02
SIGNALING BY PDGF 57 3.11e-02 0.165000 1.27e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 15 2.68e-01 0.165000 5.11e-01
OTHER SEMAPHORIN INTERACTIONS 19 2.14e-01 0.165000 4.52e-01
GABA RECEPTOR ACTIVATION 53 3.84e-02 -0.164000 1.50e-01
ASSEMBLY OF THE HIV VIRION 16 2.55e-01 -0.164000 4.96e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 1.73e-01 0.164000 4.03e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 1.29e-02 0.164000 6.49e-02
MISMATCH REPAIR 14 2.91e-01 -0.163000 5.28e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.91e-02 0.162000 2.22e-01
G PROTEIN BETA GAMMA SIGNALLING 30 1.25e-01 -0.162000 3.28e-01
CA DEPENDENT EVENTS 36 9.41e-02 0.161000 2.69e-01
INTERLEUKIN 1 SIGNALING 96 6.35e-03 -0.161000 3.66e-02
RHOH GTPASE CYCLE 37 8.97e-02 -0.161000 2.61e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 2.32e-03 0.161000 1.66e-02
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.84e-01 0.160000 4.18e-01
THE PHOTOTRANSDUCTION CASCADE 21 2.05e-01 -0.160000 4.42e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 3.19e-01 0.160000 5.60e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 4.32e-02 -0.159000 1.61e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.61e-01 -0.159000 6.06e-01
FRS MEDIATED FGFR2 SIGNALING 18 2.43e-01 -0.159000 4.88e-01
GAB1 SIGNALOSOME 13 3.21e-01 0.159000 5.62e-01
PROTEIN FOLDING 89 9.73e-03 -0.159000 5.20e-02
COHESIN LOADING ONTO CHROMATIN 10 3.86e-01 -0.158000 6.32e-01
NUCLEAR ENVELOPE BREAKDOWN 49 5.54e-02 0.158000 1.90e-01
INSULIN PROCESSING 24 1.81e-01 -0.158000 4.14e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.44e-01 -0.158000 5.86e-01
KINESINS 48 5.87e-02 0.158000 1.99e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 4.14e-02 0.158000 1.57e-01
RHO GTPASES ACTIVATE ROCKS 19 2.39e-01 -0.156000 4.84e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 2.85e-01 -0.154000 5.24e-01
RND2 GTPASE CYCLE 38 1.00e-01 0.154000 2.80e-01
SIGNALING BY FGFR2 IIIA TM 19 2.45e-01 -0.154000 4.88e-01
SIGNALING BY EGFR IN CANCER 21 2.22e-01 -0.154000 4.62e-01
INFLAMMASOMES 19 2.49e-01 -0.153000 4.90e-01
GAP JUNCTION TRAFFICKING AND REGULATION 34 1.24e-01 -0.153000 3.24e-01
RHOV GTPASE CYCLE 32 1.35e-01 0.153000 3.44e-01
PCP CE PATHWAY 91 1.21e-02 -0.152000 6.23e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 1.66e-02 0.152000 7.92e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 2.07e-01 -0.152000 4.45e-01
METALLOPROTEASE DUBS 26 1.80e-01 -0.152000 4.14e-01
CHROMOSOME MAINTENANCE 101 8.69e-03 -0.151000 4.72e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 1.63e-01 -0.150000 3.83e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 3.91e-01 -0.149000 6.37e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 26 1.88e-01 -0.149000 4.23e-01
BIOLOGICAL OXIDATIONS 122 4.56e-03 -0.149000 2.90e-02
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 2.62e-01 -0.149000 5.03e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 2.89e-01 0.149000 5.28e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 2.39e-01 0.149000 4.84e-01
RECEPTOR MEDIATED MITOPHAGY 11 3.94e-01 -0.149000 6.38e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 7.57e-02 0.148000 2.36e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 1.42e-01 -0.148000 3.57e-01
DISEASES OF MITOTIC CELL CYCLE 37 1.20e-01 -0.148000 3.19e-01
TRAFFICKING OF AMPA RECEPTORS 31 1.55e-01 0.148000 3.77e-01
MRNA SPLICING MINOR PATHWAY 52 6.58e-02 -0.148000 2.17e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 2.11e-01 -0.147000 4.51e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 3.97e-01 -0.147000 6.41e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 2.25e-01 -0.146000 4.68e-01
CARDIAC CONDUCTION 108 8.74e-03 0.146000 4.72e-02
TNF SIGNALING 43 9.83e-02 0.146000 2.77e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 1.30e-01 -0.146000 3.37e-01
INTERLEUKIN 10 SIGNALING 20 2.60e-01 -0.146000 5.02e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 2.37e-01 0.146000 4.84e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 1.49e-01 0.145000 3.66e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 4.26e-01 -0.145000 6.62e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 3.31e-01 0.145000 5.72e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.02e-01 -0.145000 5.39e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 1.60e-01 0.143000 3.83e-01
LYSOSOME VESICLE BIOGENESIS 32 1.62e-01 -0.143000 3.83e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 1.91e-01 0.143000 4.26e-01
RHO GTPASES ACTIVATE PAKS 21 2.58e-01 -0.143000 5.00e-01
ONCOGENE INDUCED SENESCENCE 32 1.63e-01 0.143000 3.83e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 80 2.81e-02 -0.142000 1.19e-01
CD28 DEPENDENT PI3K AKT SIGNALING 20 2.72e-01 0.142000 5.13e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.85e-01 -0.142000 5.24e-01
G PROTEIN MEDIATED EVENTS 52 7.70e-02 0.142000 2.39e-01
SYNTHESIS OF PA 29 1.87e-01 0.141000 4.23e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 2.04e-01 -0.141000 4.41e-01
HATS ACETYLATE HISTONES 92 1.93e-02 0.141000 8.80e-02
SIGNALING BY WNT IN CANCER 30 1.82e-01 0.141000 4.14e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 65 4.98e-02 -0.141000 1.76e-01
APOPTOTIC EXECUTION PHASE 45 1.03e-01 -0.141000 2.85e-01
SHC MEDIATED CASCADE FGFR1 14 3.63e-01 -0.140000 6.07e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 4.21e-01 0.140000 6.57e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 107 1.25e-02 0.140000 6.37e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 3.33e-01 0.140000 5.74e-01
SIGNALLING TO RAS 18 3.08e-01 0.139000 5.48e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 4.06e-01 0.139000 6.45e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 4.67e-02 -0.139000 1.68e-01
INTERLEUKIN 7 SIGNALING 20 2.84e-01 0.138000 5.24e-01
RNA POLYMERASE I PROMOTER ESCAPE 47 1.02e-01 -0.138000 2.83e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 30 1.92e-01 -0.138000 4.26e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 2.73e-04 -0.137000 2.60e-03
PURINE SALVAGE 12 4.10e-01 -0.137000 6.49e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 2.01e-01 0.137000 4.38e-01
SHC MEDIATED CASCADE FGFR3 13 3.92e-01 -0.137000 6.38e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 3.95e-01 0.136000 6.38e-01
RND3 GTPASE CYCLE 38 1.46e-01 0.136000 3.64e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 1.83e-01 0.136000 4.15e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 4.57e-01 0.136000 6.87e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 9.10e-02 -0.136000 2.63e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 57 7.77e-02 0.135000 2.40e-01
COMPLEMENT CASCADE 24 2.52e-01 -0.135000 4.94e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 188 1.43e-03 0.135000 1.12e-02
SARS COV 1 INFECTION 48 1.07e-01 -0.135000 2.93e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 8.73e-02 0.135000 2.59e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 2.77e-01 0.134000 5.18e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 4.06e-01 0.133000 6.45e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 40 1.45e-01 0.133000 3.62e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 2.42e-01 0.133000 4.88e-01
ION CHANNEL TRANSPORT 139 7.64e-03 0.131000 4.28e-02
INFECTIOUS DISEASE 723 2.52e-09 -0.131000 1.23e-07
RHO GTPASE CYCLE 422 4.40e-06 0.131000 7.26e-05
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 23 2.78e-01 -0.131000 5.19e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 1.14e-01 0.131000 3.08e-01
KERATAN SULFATE BIOSYNTHESIS 24 2.70e-01 0.130000 5.12e-01
NOD1 2 SIGNALING PATHWAY 34 1.90e-01 0.130000 4.25e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.38e-01 0.129000 6.71e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 4.02e-01 0.129000 6.44e-01
RESOLUTION OF SISTER CHROMATID COHESION 101 2.48e-02 -0.129000 1.08e-01
ACYL CHAIN REMODELLING OF PS 14 4.03e-01 0.129000 6.44e-01
SENSORY PROCESSING OF SOUND 60 8.58e-02 0.128000 2.55e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 4.42e-01 0.128000 6.76e-01
TP53 REGULATES METABOLIC GENES 85 4.29e-02 -0.127000 1.61e-01
CIRCADIAN CLOCK 68 7.06e-02 0.127000 2.26e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 3.15e-01 0.127000 5.57e-01
INTEGRIN CELL SURFACE INTERACTIONS 71 6.52e-02 0.127000 2.15e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 9.03e-02 0.126000 2.62e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.47e-01 -0.126000 4.89e-01
MITOTIC G2 G2 M PHASES 186 3.21e-03 -0.125000 2.17e-02
PROLACTIN RECEPTOR SIGNALING 11 4.72e-01 0.125000 6.96e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 12 4.53e-01 -0.125000 6.85e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 53 1.16e-01 0.125000 3.10e-01
PI 3K CASCADE FGFR4 11 4.73e-01 -0.125000 6.96e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 2.64e-01 -0.124000 5.05e-01
TBC RABGAPS 43 1.62e-01 0.123000 3.83e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 2.96e-01 -0.123000 5.34e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 2.14e-01 0.123000 4.52e-01
PI 3K CASCADE FGFR2 16 3.94e-01 -0.123000 6.38e-01
THE NLRP3 INFLAMMASOME 15 4.09e-01 -0.123000 6.49e-01
ELASTIC FIBRE FORMATION 36 2.02e-01 0.123000 4.39e-01
ERK MAPK TARGETS 22 3.20e-01 0.123000 5.61e-01
PEROXISOMAL PROTEIN IMPORT 57 1.10e-01 -0.122000 3.00e-01
LDL CLEARANCE 16 3.97e-01 -0.122000 6.41e-01
ION HOMEOSTASIS 49 1.40e-01 0.122000 3.55e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 35 2.13e-01 -0.122000 4.52e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.07e-01 0.121000 7.20e-01
INTEGRATION OF ENERGY METABOLISM 98 3.88e-02 0.121000 1.50e-01
METABOLISM OF NUCLEOTIDES 92 4.56e-02 -0.121000 1.66e-01
CHONDROITIN SULFATE BIOSYNTHESIS 19 3.65e-01 0.120000 6.08e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 2.08e-01 0.120000 4.46e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 4.24e-01 -0.119000 6.62e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 1.05e-01 -0.119000 2.89e-01
VIRAL MESSENGER RNA SYNTHESIS 42 1.82e-01 0.119000 4.14e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 4.26e-01 -0.119000 6.62e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 2.61e-01 -0.118000 5.03e-01
HS GAG BIOSYNTHESIS 30 2.62e-01 0.118000 5.03e-01
FCERI MEDIATED MAPK ACTIVATION 28 2.79e-01 -0.118000 5.19e-01
HCMV EARLY EVENTS 80 6.82e-02 0.118000 2.21e-01
DNA STRAND ELONGATION 32 2.49e-01 -0.118000 4.90e-01
MUCOPOLYSACCHARIDOSES 11 4.99e-01 0.118000 7.12e-01
M PHASE 339 2.05e-04 -0.118000 2.05e-03
RA BIOSYNTHESIS PATHWAY 14 4.46e-01 -0.118000 6.80e-01
ADHERENS JUNCTIONS INTERACTIONS 29 2.73e-01 -0.118000 5.16e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 139 1.76e-02 -0.117000 8.24e-02
PLASMA LIPOPROTEIN REMODELING 15 4.34e-01 -0.117000 6.68e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 1.78e-01 0.116000 4.12e-01
HEME BIOSYNTHESIS 13 4.69e-01 0.116000 6.96e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 2.35e-01 0.116000 4.81e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 3.28e-01 0.115000 5.68e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 5.29e-01 -0.115000 7.32e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 46 1.77e-01 0.115000 4.12e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 1.92e-01 -0.115000 4.26e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.85e-01 -0.114000 4.20e-01
GLYCOSAMINOGLYCAN METABOLISM 115 3.47e-02 0.114000 1.39e-01
ARACHIDONIC ACID METABOLISM 39 2.18e-01 -0.114000 4.57e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.79e-01 0.114000 6.26e-01
ANTIMICROBIAL PEPTIDES 13 4.78e-01 -0.114000 7.00e-01
HS GAG DEGRADATION 21 3.67e-01 0.114000 6.12e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 35 2.47e-01 0.113000 4.89e-01
MHC CLASS II ANTIGEN PRESENTATION 102 4.86e-02 -0.113000 1.73e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 3.94e-01 0.113000 6.38e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.49e-01 -0.113000 5.91e-01
INNATE IMMUNE SYSTEM 773 1.10e-07 -0.113000 3.06e-06
AQUAPORIN MEDIATED TRANSPORT 40 2.17e-01 -0.113000 4.57e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 5.18e-01 0.113000 7.32e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 2.13e-01 0.112000 4.52e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 144 2.02e-02 -0.112000 9.10e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 4.38e-01 0.112000 6.71e-01
HEDGEHOG ON STATE 83 7.91e-02 -0.112000 2.43e-01
SEMAPHORIN INTERACTIONS 64 1.23e-01 0.111000 3.24e-01
MET PROMOTES CELL MOTILITY 39 2.30e-01 0.111000 4.76e-01
SULFUR AMINO ACID METABOLISM 22 3.68e-01 -0.111000 6.12e-01
NUCLEOBASE CATABOLISM 31 2.90e-01 -0.110000 5.28e-01
NEDDYLATION 218 5.36e-03 -0.110000 3.22e-02
MYOGENESIS 25 3.44e-01 0.109000 5.86e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 24 3.54e-01 -0.109000 5.97e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 5.33e-01 0.109000 7.34e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 3.89e-01 -0.109000 6.36e-01
SARS COV 2 INFECTION 65 1.31e-01 -0.108000 3.39e-01
SIGNALING BY ERYTHROPOIETIN 24 3.59e-01 0.108000 6.04e-01
PEXOPHAGY 11 5.35e-01 0.108000 7.35e-01
ONCOGENIC MAPK SIGNALING 77 1.02e-01 0.108000 2.83e-01
FRS MEDIATED FGFR1 SIGNALING 16 4.59e-01 -0.107000 6.89e-01
PI3K AKT SIGNALING IN CANCER 87 8.48e-02 0.107000 2.53e-01
PLATELET CALCIUM HOMEOSTASIS 27 3.39e-01 0.106000 5.82e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 1.90e-01 0.106000 4.25e-01
STRIATED MUSCLE CONTRACTION 28 3.33e-01 -0.106000 5.74e-01
PYRIMIDINE CATABOLISM 10 5.64e-01 -0.105000 7.50e-01
CELL CYCLE MITOTIC 474 9.36e-05 -0.105000 1.01e-03
REGULATION OF TNFR1 SIGNALING 34 2.93e-01 0.104000 5.30e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 11 5.50e-01 -0.104000 7.41e-01
KERATAN SULFATE DEGRADATION 11 5.53e-01 -0.103000 7.42e-01
MITOTIC TELOPHASE CYTOKINESIS 13 5.22e-01 -0.103000 7.32e-01
HEME SIGNALING 44 2.40e-01 0.102000 4.85e-01
NEURONAL SYSTEM 366 8.05e-04 0.102000 6.94e-03
MEIOSIS 63 1.61e-01 -0.102000 3.83e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.53e-01 0.102000 6.85e-01
PEPTIDE LIGAND BINDING RECEPTORS 94 8.79e-02 -0.102000 2.59e-01
FRS MEDIATED FGFR3 SIGNALING 15 4.95e-01 -0.102000 7.10e-01
CTLA4 INHIBITORY SIGNALING 20 4.31e-01 -0.102000 6.64e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 343 1.28e-03 -0.101000 1.02e-02
SIGNALING BY RETINOIC ACID 34 3.06e-01 -0.101000 5.46e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 2.62e-01 0.101000 5.03e-01
PERK REGULATES GENE EXPRESSION 28 3.55e-01 -0.101000 5.97e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 5.29e-01 -0.101000 7.32e-01
INTERLEUKIN 1 FAMILY SIGNALING 122 5.49e-02 -0.101000 1.89e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 5.30e-01 0.101000 7.32e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 3.41e-01 0.100000 5.85e-01
L1CAM INTERACTIONS 107 7.31e-02 0.100000 2.31e-01
KERATAN SULFATE KERATIN METABOLISM 30 3.42e-01 0.100000 5.86e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 5.50e-01 -0.099800 7.41e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 4.66e-01 0.099300 6.95e-01
MICRORNA MIRNA BIOGENESIS 24 4.00e-01 0.099200 6.42e-01
SIGNALING BY NTRK3 TRKC 17 4.79e-01 0.099200 7.00e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 5.37e-01 0.098800 7.37e-01
INTERLEUKIN 27 SIGNALING 10 5.88e-01 0.098800 7.68e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 5.22e-01 0.098800 7.32e-01
NICOTINATE METABOLISM 24 4.02e-01 0.098800 6.44e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 5.22e-01 -0.098700 7.32e-01
CELL CYCLE 591 4.92e-05 -0.098100 5.88e-04
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 5.26e-01 0.097800 7.32e-01
PEROXISOMAL LIPID METABOLISM 26 3.88e-01 -0.097700 6.36e-01
SIGNALING BY EGFR 46 2.53e-01 0.097500 4.94e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 25 3.99e-01 -0.097400 6.42e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 13 5.45e-01 0.097100 7.41e-01
TELOMERE MAINTENANCE 78 1.39e-01 -0.097000 3.53e-01
REPRODUCTION 75 1.48e-01 -0.096800 3.64e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 4.54e-01 -0.096700 6.85e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 5.04e-01 -0.096500 7.17e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 1.80e-01 -0.096200 4.14e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 21 4.47e-01 -0.095900 6.80e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 3.14e-01 -0.095700 5.57e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 5.22e-01 -0.095400 7.32e-01
RND1 GTPASE CYCLE 37 3.16e-01 0.095300 5.58e-01
SODIUM CALCIUM EXCHANGERS 10 6.02e-01 0.095300 7.78e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 4.54e-01 0.094400 6.85e-01
INITIAL TRIGGERING OF COMPLEMENT 11 5.88e-01 0.094200 7.68e-01
HDACS DEACETYLATE HISTONES 46 2.70e-01 0.094100 5.12e-01
SIGNALING BY INSULIN RECEPTOR 61 2.04e-01 -0.094000 4.42e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 58 2.22e-01 -0.092800 4.62e-01
CELL CELL COMMUNICATION 106 9.95e-02 0.092700 2.79e-01
RETROGRADE NEUROTROPHIN SIGNALLING 13 5.64e-01 0.092500 7.50e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.41e-01 0.092500 3.55e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 5.65e-01 -0.092200 7.50e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 25 4.27e-01 -0.091800 6.62e-01
INTERLEUKIN 17 SIGNALING 66 1.98e-01 0.091600 4.34e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 3.63e-01 -0.091600 6.07e-01
BILE ACID AND BILE SALT METABOLISM 25 4.28e-01 0.091500 6.62e-01
OXIDATIVE STRESS INDUCED SENESCENCE 78 1.62e-01 0.091500 3.83e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 5.53e-01 0.091500 7.42e-01
SIGNALING BY INTERLEUKINS 347 3.50e-03 -0.091400 2.33e-02
ERBB2 REGULATES CELL MOTILITY 13 5.69e-01 0.091200 7.53e-01
DUAL INCISION IN TC NER 64 2.07e-01 -0.091200 4.46e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 4.92e-01 -0.091100 7.08e-01
DAP12 SIGNALING 24 4.41e-01 -0.090800 6.76e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 4.51e-01 -0.090700 6.84e-01
SIGNALING BY GPCR 459 9.35e-04 0.090400 7.88e-03
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.45e-01 -0.090400 7.41e-01
REGULATION OF IFNA SIGNALING 12 5.88e-01 0.090300 7.68e-01
DISEASES OF METABOLISM 201 2.87e-02 0.089600 1.20e-01
G ALPHA S SIGNALLING EVENTS 98 1.26e-01 0.089500 3.28e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 4.90e-01 0.089200 7.08e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 1.62e-01 -0.088900 3.83e-01
HYALURONAN METABOLISM 15 5.53e-01 0.088600 7.42e-01
TRANSCRIPTION OF THE HIV GENOME 67 2.12e-01 -0.088300 4.52e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 1.16e-01 -0.088100 3.10e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 10 6.30e-01 -0.088100 7.97e-01
GLUCONEOGENESIS 27 4.29e-01 -0.088000 6.62e-01
SELECTIVE AUTOPHAGY 71 2.00e-01 -0.088000 4.37e-01
SIGNALING BY FLT3 FUSION PROTEINS 18 5.21e-01 -0.087400 7.32e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 19 5.12e-01 -0.086900 7.24e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 5.12e-01 -0.086900 7.24e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 61 2.41e-01 0.086900 4.87e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 4.19e-01 0.086700 6.56e-01
ZINC TRANSPORTERS 16 5.49e-01 -0.086500 7.41e-01
MAP2K AND MAPK ACTIVATION 36 3.72e-01 0.086100 6.17e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 5.64e-01 -0.086000 7.50e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.34e-01 -0.085500 4.80e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 4.27e-01 -0.085300 6.62e-01
FORMATION OF THE CORNIFIED ENVELOPE 29 4.27e-01 0.085300 6.62e-01
KERATINIZATION 29 4.27e-01 0.085300 6.62e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 6.10e-01 -0.085100 7.83e-01
DISEASES OF PROGRAMMED CELL DEATH 54 2.80e-01 -0.085000 5.20e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 6.25e-01 0.085000 7.95e-01
SIGNALING BY KIT IN DISEASE 20 5.12e-01 -0.084800 7.24e-01
FGFR2 ALTERNATIVE SPLICING 25 4.63e-01 -0.084800 6.94e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 4.15e-01 -0.084600 6.54e-01
JOSEPHIN DOMAIN DUBS 11 6.27e-01 -0.084500 7.96e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.91e-01 -0.083900 5.28e-01
DEADENYLATION OF MRNA 25 4.68e-01 -0.083800 6.96e-01
HIV LIFE CYCLE 142 8.53e-02 -0.083700 2.54e-01
RHOQ GTPASE CYCLE 57 2.76e-01 0.083500 5.17e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 4.17e-01 0.082900 6.55e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 5.43e-01 -0.082800 7.41e-01
SIGNALING BY FGFR1 42 3.55e-01 -0.082600 5.97e-01
FOXO MEDIATED TRANSCRIPTION 57 2.83e-01 -0.082300 5.24e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 4.90e-01 0.081400 7.08e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 5.75e-01 0.080900 7.60e-01
AMINO ACIDS REGULATE MTORC1 51 3.25e-01 -0.079800 5.64e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 6.06e-01 -0.079600 7.81e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 2.64e-01 0.079500 5.05e-01
UB SPECIFIC PROCESSING PROTEASES 169 7.49e-02 -0.079500 2.35e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 622 7.60e-04 0.079400 6.64e-03
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 43 3.68e-01 -0.079300 6.12e-01
CD209 DC SIGN SIGNALING 18 5.62e-01 -0.079000 7.50e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 31 4.49e-01 0.078600 6.81e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 3.75e-01 0.078200 6.21e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 22 5.27e-01 -0.078000 7.32e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 6.55e-01 0.077900 8.12e-01
RHO GTPASES ACTIVATE FORMINS 118 1.47e-01 -0.077300 3.64e-01
DUAL INCISION IN GG NER 40 3.99e-01 -0.077100 6.42e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 5.94e-01 -0.077000 7.71e-01
REGULATION OF KIT SIGNALING 16 5.94e-01 0.077000 7.71e-01
BASE EXCISION REPAIR AP SITE FORMATION 29 4.73e-01 -0.077000 6.96e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 7.76e-02 -0.077000 2.40e-01
RAB REGULATION OF TRAFFICKING 119 1.47e-01 0.077000 3.64e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 5.23e-01 -0.076900 7.32e-01
PRC2 METHYLATES HISTONES AND DNA 29 4.74e-01 -0.076900 6.96e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 4.74e-01 0.076900 6.96e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 4.13e-01 -0.076700 6.53e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 6.46e-01 0.076600 8.09e-01
N GLYCAN ANTENNAE ELONGATION 15 6.07e-01 0.076600 7.82e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 6.33e-01 -0.076600 7.98e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 4.18e-01 -0.076000 6.55e-01
SIGNALING BY FGFR2 62 3.02e-01 -0.075900 5.39e-01
EGFR DOWNREGULATION 27 4.97e-01 0.075600 7.10e-01
RHO GTPASES ACTIVATE CIT 18 5.79e-01 -0.075500 7.63e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 3.01e-01 -0.075400 5.39e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 6.65e-01 0.075300 8.18e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 6.52e-01 0.075200 8.12e-01
ADAPTIVE IMMUNE SYSTEM 596 1.84e-03 -0.075000 1.36e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.57e-01 -0.074800 4.99e-01
GLUCOSE METABOLISM 81 2.45e-01 0.074800 4.88e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.68e-01 0.074700 8.19e-01
NUCLEAR SIGNALING BY ERBB4 30 4.80e-01 0.074600 7.00e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 2.44e-01 0.074500 4.88e-01
METABOLISM OF FOLATE AND PTERINES 15 6.17e-01 0.074500 7.92e-01
AUTOPHAGY 138 1.32e-01 -0.074400 3.39e-01
DAP12 INTERACTIONS 29 4.89e-01 -0.074300 7.07e-01
SIGNALING BY BMP 24 5.30e-01 -0.074100 7.32e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 5.98e-01 0.074000 7.75e-01
SIGNALING BY ACTIVIN 12 6.58e-01 0.073900 8.13e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 31 4.78e-01 0.073700 7.00e-01
ATTENUATION PHASE 23 5.44e-01 -0.073200 7.41e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 63 3.17e-01 -0.072900 5.58e-01
REGULATION OF FZD BY UBIQUITINATION 19 5.83e-01 -0.072800 7.66e-01
SHC1 EVENTS IN ERBB4 SIGNALING 12 6.63e-01 -0.072700 8.18e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 2.21e-01 0.072400 4.61e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 545 4.00e-03 -0.072400 2.61e-02
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 6.52e-01 -0.072300 8.12e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 6.94e-01 -0.071900 8.37e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 4.62e-01 0.071900 6.92e-01
MRNA CAPPING 29 5.03e-01 -0.071800 7.17e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 2.54e-01 -0.070800 4.95e-01
GLYCOLYSIS 67 3.17e-01 0.070700 5.58e-01
INTERFERON GAMMA SIGNALING 75 2.90e-01 -0.070700 5.28e-01
REGULATION OF SIGNALING BY CBL 22 5.68e-01 -0.070300 7.53e-01
G ALPHA Z SIGNALLING EVENTS 45 4.16e-01 -0.070100 6.54e-01
PTEN REGULATION 134 1.62e-01 -0.070000 3.83e-01
GENE SILENCING BY RNA 82 2.74e-01 0.069900 5.16e-01
CARGO CONCENTRATION IN THE ER 30 5.09e-01 0.069700 7.22e-01
G0 AND EARLY G1 25 5.47e-01 -0.069600 7.41e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 4.38e-02 -0.069400 1.61e-01
ERKS ARE INACTIVATED 13 6.67e-01 0.068800 8.19e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 47 4.16e-01 -0.068700 6.54e-01
PECAM1 INTERACTIONS 12 6.81e-01 0.068600 8.30e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 6.57e-01 0.068600 8.13e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 4.32e-01 -0.068500 6.65e-01
FERTILIZATION 12 6.85e-01 -0.067700 8.32e-01
AGGREPHAGY 34 4.97e-01 -0.067300 7.10e-01
NONHOMOLOGOUS END JOINING NHEJ 43 4.46e-01 -0.067200 6.80e-01
COSTIMULATION BY THE CD28 FAMILY 49 4.16e-01 -0.067200 6.54e-01
RESOLUTION OF ABASIC SITES AP SITES 37 4.79e-01 -0.067200 7.00e-01
BASE EXCISION REPAIR 56 3.85e-01 -0.067100 6.32e-01
CD28 CO STIMULATION 30 5.27e-01 -0.066800 7.32e-01
GABA B RECEPTOR ACTIVATION 39 4.72e-01 -0.066600 6.96e-01
SIGNALING BY ERBB4 56 3.91e-01 -0.066400 6.37e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 6.46e-01 -0.066300 8.09e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 3.82e-01 0.066300 6.30e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 23 5.83e-01 -0.066100 7.66e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 5.46e-01 -0.066000 7.41e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 4.45e-01 0.065800 6.79e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 168 1.42e-01 0.065800 3.57e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 7.20e-01 0.065500 8.51e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 5.98e-01 0.064900 7.75e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 6.25e-01 -0.064700 7.95e-01
RHOG GTPASE CYCLE 73 3.39e-01 0.064700 5.82e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 90 2.89e-01 -0.064700 5.28e-01
P75NTR SIGNALS VIA NF KB 16 6.54e-01 0.064700 8.12e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 139 1.89e-01 0.064500 4.25e-01
SIGNALING BY WNT 268 7.20e-02 -0.064000 2.29e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 6.21e-01 0.063900 7.93e-01
PI3K EVENTS IN ERBB2 SIGNALING 14 6.83e-01 0.063100 8.32e-01
TRNA AMINOACYLATION 42 4.80e-01 -0.063000 7.00e-01
MATURATION OF NUCLEOPROTEIN 10 7.30e-01 -0.063000 8.55e-01
SIGNALING BY MET 75 3.46e-01 0.063000 5.87e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 6.26e-01 -0.062900 7.95e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 44 4.73e-01 -0.062500 6.96e-01
SARS COV INFECTIONS 140 2.02e-01 -0.062500 4.40e-01
POTASSIUM CHANNELS 90 3.07e-01 0.062400 5.46e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 102 2.78e-01 0.062200 5.19e-01
HEDGEHOG OFF STATE 107 2.68e-01 -0.062000 5.11e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 6.72e-01 -0.061100 8.23e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 6.95e-01 0.060600 8.38e-01
FANCONI ANEMIA PATHWAY 36 5.31e-01 0.060400 7.32e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 64 4.04e-01 -0.060300 6.44e-01
SIGNALING BY VEGF 101 3.01e-01 0.059600 5.39e-01
PREGNENOLONE BIOSYNTHESIS 12 7.21e-01 -0.059500 8.51e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 4.71e-01 -0.059500 6.96e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 3.45e-01 0.059300 5.87e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 7.11e-01 -0.059300 8.46e-01
MUSCLE CONTRACTION 163 1.93e-01 0.059200 4.26e-01
SIGNALING BY FGFR 72 3.90e-01 -0.058600 6.37e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 7.25e-01 -0.058600 8.52e-01
PI 3K CASCADE FGFR1 14 7.05e-01 -0.058500 8.44e-01
MTOR SIGNALLING 40 5.23e-01 -0.058400 7.32e-01
SIGNALING BY NODAL 16 6.87e-01 0.058200 8.33e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 6.88e-01 -0.058000 8.33e-01
GRB2 EVENTS IN ERBB2 SIGNALING 14 7.08e-01 -0.057900 8.45e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 6.40e-01 -0.057600 8.04e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 6.84e-01 -0.057100 8.32e-01
PARASITE INFECTION 55 4.64e-01 0.057100 6.94e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 3.81e-01 0.057100 6.28e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 5.77e-01 0.057000 7.61e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 90 3.52e-01 0.056700 5.95e-01
EXTENSION OF TELOMERES 49 4.93e-01 -0.056700 7.08e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.46e-01 -0.056500 8.63e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 6.78e-01 0.056400 8.28e-01
SIGNALING BY NTRKS 129 2.71e-01 0.056100 5.13e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 4.05e-01 -0.056000 6.45e-01
CELLULAR SENESCENCE 141 2.52e-01 0.055900 4.94e-01
REGULATION OF TP53 ACTIVITY 151 2.44e-01 0.055000 4.88e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 5.53e-01 0.054900 7.42e-01
SIGNALING BY SCF KIT 41 5.46e-01 0.054500 7.41e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 6.33e-01 -0.054000 7.98e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.85e-01 0.054000 7.05e-01
SIGNALING BY HIPPO 20 6.78e-01 -0.053600 8.28e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 6.19e-01 -0.053400 7.93e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 3.80e-01 0.053300 6.28e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 459 5.14e-02 0.053200 1.79e-01
SYNTHESIS OF PC 25 6.45e-01 0.053200 8.09e-01
TRNA PROCESSING IN THE NUCLEUS 56 4.95e-01 0.052700 7.10e-01
RECYCLING PATHWAY OF L1 40 5.65e-01 0.052600 7.50e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.51e-01 -0.052400 8.12e-01
NUCLEOBASE BIOSYNTHESIS 15 7.27e-01 -0.052200 8.52e-01
BASIGIN INTERACTIONS 23 6.65e-01 -0.052100 8.18e-01
SIGNALING BY PTK6 50 5.25e-01 0.052000 7.32e-01
RNA POLYMERASE III TRANSCRIPTION 41 5.65e-01 -0.051900 7.50e-01
NUCLEOTIDE EXCISION REPAIR 109 3.50e-01 -0.051800 5.92e-01
RNA POLYMERASE I TRANSCRIPTION 67 4.65e-01 -0.051600 6.95e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 16 7.25e-01 0.050900 8.52e-01
MITOTIC PROMETAPHASE 176 2.46e-01 -0.050800 4.88e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 5.66e-01 0.050600 7.50e-01
SLC TRANSPORTER DISORDERS 75 4.49e-01 0.050600 6.81e-01
POLO LIKE KINASE MEDIATED EVENTS 14 7.44e-01 0.050500 8.62e-01
PLATELET SENSITIZATION BY LDL 15 7.37e-01 -0.050200 8.60e-01
SIGNALING BY FGFR4 32 6.26e-01 -0.049800 7.95e-01
NUCLEOTIDE SALVAGE 21 6.97e-01 -0.049100 8.39e-01
PI 3K CASCADE FGFR3 13 7.60e-01 -0.048900 8.74e-01
SIALIC ACID METABOLISM 32 6.33e-01 -0.048800 7.98e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.70e-01 0.048700 8.82e-01
ESR MEDIATED SIGNALING 163 2.84e-01 -0.048700 5.24e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 7.21e-01 -0.048600 8.51e-01
INTERFERON ALPHA BETA SIGNALING 53 5.47e-01 -0.047800 7.41e-01
PLATELET HOMEOSTASIS 78 4.67e-01 -0.047600 6.96e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 5.21e-01 -0.047200 7.32e-01
NICOTINAMIDE SALVAGING 15 7.52e-01 -0.047100 8.69e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 7.38e-01 0.047000 8.60e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 7.70e-01 0.046900 8.82e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 4.81e-01 -0.046800 7.01e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 5.25e-01 -0.046300 7.32e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 60 5.36e-01 0.046200 7.35e-01
RESOLUTION OF D LOOP STRUCTURES 30 6.62e-01 0.046200 8.17e-01
INTERFERON SIGNALING 163 3.15e-01 -0.045700 5.57e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 7.38e-01 -0.045600 8.60e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 6.05e-01 0.045600 7.80e-01
COPII MEDIATED VESICLE TRANSPORT 64 5.30e-01 0.045400 7.32e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 238 2.30e-01 0.045200 4.76e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 5.00e-01 -0.045100 7.13e-01
ERYTHROPOIETIN ACTIVATES RAS 13 7.79e-01 -0.044900 8.90e-01
RAC3 GTPASE CYCLE 88 4.71e-01 0.044400 6.96e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 5.48e-01 0.044400 7.41e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 50 5.89e-01 -0.044200 7.68e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 5.72e-01 -0.044100 7.55e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 8.10e-01 0.044000 9.02e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 8.10e-01 0.044000 9.02e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 4.85e-01 0.043600 7.05e-01
ENDOGENOUS STEROLS 20 7.38e-01 -0.043200 8.60e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 6.78e-01 0.043000 8.28e-01
SIGNALING BY NUCLEAR RECEPTORS 221 2.72e-01 -0.043000 5.13e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 6.28e-01 -0.042700 7.96e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 7.99e-01 -0.042500 8.99e-01
HIV TRANSCRIPTION ELONGATION 42 6.36e-01 -0.042300 7.99e-01
FLT3 SIGNALING IN DISEASE 27 7.05e-01 -0.042000 8.44e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 92 4.87e-01 0.041900 7.07e-01
METABOLISM OF CARBOHYDRATES 259 2.47e-01 0.041900 4.89e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 6.03e-01 0.041700 7.79e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 7.54e-01 -0.041500 8.70e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 7.09e-01 -0.041500 8.45e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 44 6.35e-01 0.041400 7.99e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 7.58e-01 0.040900 8.72e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 15 7.87e-01 0.040300 8.94e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 41 6.56e-01 0.040300 8.12e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 7.88e-01 -0.040200 8.94e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 7.13e-01 -0.039500 8.46e-01
RNA POLYMERASE II TRANSCRIPTION 1085 2.96e-02 -0.039400 1.24e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 85 5.34e-01 -0.039100 7.34e-01
MET RECEPTOR RECYCLING 10 8.31e-01 -0.039000 9.13e-01
SIGNALING BY FGFR IN DISEASE 55 6.19e-01 -0.038700 7.93e-01
DEUBIQUITINATION 243 3.02e-01 -0.038500 5.39e-01
CILIUM ASSEMBLY 190 3.62e-01 0.038400 6.06e-01
DNA DAMAGE RECOGNITION IN GG NER 38 6.86e-01 -0.037900 8.33e-01
METABOLISM OF STEROIDS 113 4.88e-01 -0.037800 7.07e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 7.71e-01 -0.037600 8.82e-01
PROLONGED ERK ACTIVATION EVENTS 13 8.15e-01 -0.037500 9.04e-01
NEGATIVE REGULATION OF FLT3 15 8.02e-01 0.037400 8.99e-01
REGULATION OF INSULIN SECRETION 71 5.87e-01 0.037300 7.68e-01
ACYL CHAIN REMODELLING OF PC 17 7.91e-01 0.037100 8.97e-01
RAC2 GTPASE CYCLE 86 5.61e-01 0.036300 7.50e-01
HSF1 DEPENDENT TRANSACTIVATION 33 7.18e-01 0.036300 8.50e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 5.50e-01 0.036100 7.41e-01
SIGNALLING TO ERKS 32 7.25e-01 0.036000 8.52e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 4.07e-01 0.036000 6.45e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.42e-01 0.036000 8.62e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 8.30e-01 -0.035900 9.13e-01
RAF ACTIVATION 34 7.17e-01 -0.035900 8.50e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 7.45e-01 0.035500 8.63e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 6.97e-01 -0.035100 8.39e-01
SHC1 EVENTS IN ERBB2 SIGNALING 20 7.87e-01 0.034900 8.94e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 8.09e-01 0.034800 9.02e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 8.04e-01 -0.034800 8.99e-01
HCMV INFECTION 103 5.43e-01 0.034700 7.41e-01
EPHRIN SIGNALING 19 7.94e-01 0.034700 8.98e-01
DERMATAN SULFATE BIOSYNTHESIS 11 8.43e-01 0.034600 9.20e-01
TELOMERE EXTENSION BY TELOMERASE 22 7.80e-01 0.034400 8.90e-01
ACYL CHAIN REMODELLING OF PG 10 8.51e-01 -0.034300 9.23e-01
HOMOLOGY DIRECTED REPAIR 107 5.40e-01 -0.034300 7.39e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 280 3.24e-01 0.034300 5.64e-01
EPHB MEDIATED FORWARD SIGNALING 42 7.01e-01 -0.034200 8.42e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 20 7.92e-01 -0.034100 8.97e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 41 7.07e-01 0.033900 8.45e-01
RHO GTPASES ACTIVATE IQGAPS 23 7.81e-01 -0.033500 8.90e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 7.37e-01 -0.033300 8.60e-01
CELL CELL JUNCTION ORGANIZATION 50 6.87e-01 -0.032900 8.33e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 8.14e-01 -0.032900 9.04e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 88 5.94e-01 -0.032900 7.71e-01
MAPK FAMILY SIGNALING CASCADES 286 3.43e-01 0.032600 5.86e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 7.00e-01 0.032500 8.41e-01
RHO GTPASE EFFECTORS 245 3.85e-01 -0.032300 6.32e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 6.24e-01 0.032100 7.95e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 7.40e-01 -0.031900 8.61e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 6.49e-01 -0.031700 8.11e-01
SPHINGOLIPID METABOLISM 80 6.26e-01 -0.031600 7.95e-01
SUMOYLATION 161 4.92e-01 0.031400 7.08e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 8.65e-01 -0.031000 9.30e-01
AURKA ACTIVATION BY TPX2 71 6.55e-01 0.030700 8.12e-01
CLATHRIN MEDIATED ENDOCYTOSIS 130 5.51e-01 0.030300 7.41e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 8.15e-01 0.030200 9.04e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 364 3.23e-01 0.030200 5.64e-01
RHOD GTPASE CYCLE 50 7.12e-01 0.030200 8.46e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 8.63e-01 -0.030000 9.30e-01
SIGNALING BY ERBB2 47 7.26e-01 -0.029600 8.52e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 8.39e-01 -0.029300 9.18e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 8.73e-01 -0.029200 9.33e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 25 8.01e-01 0.029100 8.99e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 8.56e-01 0.029100 9.25e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 6.31e-01 0.028900 7.98e-01
SYNDECAN INTERACTIONS 26 8.02e-01 -0.028500 8.99e-01
NGF STIMULATED TRANSCRIPTION 37 7.67e-01 -0.028200 8.80e-01
SIGNALING BY ERBB2 IN CANCER 24 8.11e-01 -0.028100 9.03e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 7.09e-01 0.028100 8.45e-01
SIGNALING BY PDGFR IN DISEASE 20 8.30e-01 -0.027800 9.13e-01
GLYCOSPHINGOLIPID METABOLISM 39 7.65e-01 -0.027700 8.78e-01
METABOLISM OF PORPHYRINS 19 8.36e-01 0.027400 9.18e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 8.20e-01 0.027300 9.07e-01
CELLULAR RESPONSE TO HEAT STRESS 94 6.48e-01 -0.027200 8.11e-01
DOWNREGULATION OF ERBB2 SIGNALING 27 8.07e-01 0.027200 9.02e-01
TIGHT JUNCTION INTERACTIONS 19 8.38e-01 0.027000 9.18e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 8.67e-01 0.026900 9.31e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 4.91e-01 -0.026800 7.08e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 6.64e-01 0.026800 8.18e-01
DNA DOUBLE STRAND BREAK RESPONSE 52 7.39e-01 -0.026700 8.60e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 7.81e-01 -0.026400 8.90e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 8.55e-01 0.026300 9.25e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 6.55e-01 -0.025600 8.12e-01
METABOLISM OF VITAMINS AND COFACTORS 151 6.00e-01 0.024800 7.76e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 35 8.00e-01 0.024800 8.99e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 7.49e-01 -0.024600 8.65e-01
G1 S SPECIFIC TRANSCRIPTION 26 8.29e-01 0.024500 9.13e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 8.91e-01 -0.024000 9.40e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 22 8.46e-01 -0.023900 9.21e-01
CELL JUNCTION ORGANIZATION 74 7.23e-01 0.023800 8.52e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 8.13e-01 -0.023800 9.04e-01
VXPX CARGO TARGETING TO CILIUM 19 8.58e-01 0.023700 9.27e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.74e-01 -0.023600 9.33e-01
TRANSCRIPTIONAL REGULATION BY TP53 342 4.56e-01 -0.023500 6.87e-01
SIGNALING BY NOTCH 189 5.83e-01 0.023200 7.66e-01
NEUROTRANSMITTER RELEASE CYCLE 47 7.83e-01 0.023200 8.91e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 16 8.72e-01 0.023200 9.33e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 8.48e-01 -0.023000 9.21e-01
P38MAPK EVENTS 12 8.92e-01 0.022600 9.40e-01
MITOCHONDRIAL BIOGENESIS 92 7.11e-01 -0.022300 8.46e-01
INSULIN RECEPTOR SIGNALLING CASCADE 42 8.03e-01 0.022200 8.99e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 8.32e-01 0.022000 9.14e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 8.84e-01 -0.021700 9.40e-01
NERVOUS SYSTEM DEVELOPMENT 547 3.99e-01 -0.021200 6.42e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 8.44e-01 -0.021100 9.21e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 9.09e-01 -0.020800 9.50e-01
DEVELOPMENTAL BIOLOGY 814 3.18e-01 0.020700 5.60e-01
GPVI MEDIATED ACTIVATION CASCADE 31 8.45e-01 -0.020300 9.21e-01
INTERLEUKIN 35 SIGNALLING 10 9.13e-01 0.020100 9.50e-01
EPH EPHRIN SIGNALING 92 7.43e-01 0.019800 8.62e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1213 2.52e-01 -0.019700 4.94e-01
POTENTIAL THERAPEUTICS FOR SARS 77 7.65e-01 -0.019700 8.78e-01
TOLL LIKE RECEPTOR CASCADES 137 6.92e-01 -0.019600 8.36e-01
AMYLOID FIBER FORMATION 57 7.98e-01 -0.019600 8.99e-01
NEGATIVE REGULATION OF MET ACTIVITY 21 8.77e-01 -0.019500 9.36e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.11e-01 0.019400 9.50e-01
MEMBRANE TRAFFICKING 576 4.29e-01 0.019300 6.62e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 9.05e-01 0.019200 9.48e-01
PLASMA LIPOPROTEIN CLEARANCE 27 8.65e-01 -0.019000 9.30e-01
HCMV LATE EVENTS 65 7.94e-01 0.018700 8.98e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 282 5.91e-01 0.018700 7.69e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 8.67e-01 0.018600 9.31e-01
RHOF GTPASE CYCLE 40 8.39e-01 0.018600 9.18e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 8.89e-01 0.018600 9.40e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 6.67e-01 0.018400 8.19e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 7.56e-01 -0.018400 8.71e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 9.02e-01 0.018400 9.46e-01
SIGNAL TRANSDUCTION BY L1 21 8.88e-01 0.017800 9.40e-01
CA2 PATHWAY 56 8.19e-01 -0.017600 9.07e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 7.95e-01 0.017600 8.98e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 8.47e-01 0.017400 9.21e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 7.97e-01 -0.017300 8.99e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 9.12e-01 -0.017000 9.50e-01
SIGNALING BY NTRK2 TRKB 24 8.86e-01 0.016900 9.40e-01
SPRY REGULATION OF FGF SIGNALING 16 9.08e-01 0.016600 9.50e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 8.19e-01 -0.016600 9.07e-01
DNA METHYLATION 20 8.98e-01 -0.016600 9.43e-01
SIGNALING BY FGFR1 IN DISEASE 32 8.72e-01 -0.016400 9.33e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 8.82e-01 -0.016200 9.38e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 8.30e-01 0.016200 9.13e-01
G ALPHA I SIGNALLING EVENTS 189 7.03e-01 -0.016100 8.43e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 29 8.81e-01 -0.016000 9.38e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 9.16e-01 -0.015800 9.51e-01
SIGNALING BY FGFR3 35 8.72e-01 -0.015700 9.33e-01
ACYL CHAIN REMODELLING OF PE 16 9.15e-01 -0.015400 9.51e-01
DISEASES OF DNA REPAIR 11 9.30e-01 -0.015300 9.60e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 90 8.04e-01 -0.015200 8.99e-01
METABOLISM OF LIPIDS 610 5.26e-01 0.015100 7.32e-01
HDR THROUGH MMEJ ALT NHEJ 10 9.35e-01 0.014900 9.63e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 62 8.42e-01 -0.014700 9.20e-01
LEISHMANIA INFECTION 190 7.29e-01 0.014600 8.54e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 8.97e-01 0.014600 9.43e-01
HIV ELONGATION ARREST AND RECOVERY 32 8.91e-01 0.014000 9.40e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 57 8.55e-01 -0.014000 9.25e-01
IRAK1 RECRUITS IKK COMPLEX 14 9.28e-01 0.013900 9.60e-01
HEMOSTASIS 474 6.08e-01 0.013800 7.82e-01
FLT3 SIGNALING 37 8.87e-01 -0.013500 9.40e-01
ASPARAGINE N LINKED GLYCOSYLATION 282 6.99e-01 -0.013400 8.40e-01
METAL ION SLC TRANSPORTERS 25 9.08e-01 0.013400 9.50e-01
SURFACTANT METABOLISM 17 9.24e-01 0.013300 9.58e-01
VESICLE MEDIATED TRANSPORT 604 5.89e-01 0.012900 7.68e-01
MEIOTIC SYNAPSIS 39 8.91e-01 -0.012700 9.40e-01
RHOJ GTPASE CYCLE 54 8.74e-01 -0.012500 9.33e-01
OPIOID SIGNALLING 86 8.48e-01 -0.012000 9.21e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 8.61e-01 -0.011900 9.30e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 8.97e-01 -0.011300 9.43e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 9.21e-01 -0.011300 9.55e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 103 8.46e-01 0.011100 9.21e-01
LYSINE CATABOLISM 11 9.50e-01 0.010900 9.70e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 9.46e-01 0.010900 9.69e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 9.48e-01 0.010400 9.69e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 164 8.27e-01 -0.009890 9.13e-01
TRANSPORT OF SMALL MOLECULES 574 6.88e-01 0.009830 8.33e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 9.56e-01 0.009290 9.75e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 9.19e-01 -0.009050 9.54e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 18 9.47e-01 0.009010 9.69e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 9.40e-01 0.008900 9.67e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 9.28e-01 -0.008650 9.60e-01
SIGNALING BY HEDGEHOG 142 8.62e-01 -0.008450 9.30e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 9.32e-01 -0.008410 9.62e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 110 8.81e-01 0.008260 9.38e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.49e-01 -0.008110 9.69e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 26 9.45e-01 0.007790 9.69e-01
UNWINDING OF DNA 12 9.63e-01 0.007770 9.80e-01
OTHER INTERLEUKIN SIGNALING 19 9.57e-01 0.007070 9.76e-01
IRS MEDIATED SIGNALLING 37 9.42e-01 -0.006850 9.68e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 9.35e-01 -0.006800 9.63e-01
SENSORY PERCEPTION 148 8.87e-01 0.006790 9.40e-01
MITOTIC PROPHASE 94 9.10e-01 -0.006720 9.50e-01
SNRNP ASSEMBLY 51 9.41e-01 -0.006010 9.67e-01
PYRIMIDINE SALVAGE 10 9.74e-01 0.005970 9.86e-01
CGMP EFFECTS 15 9.69e-01 -0.005780 9.83e-01
DNA DOUBLE STRAND BREAK REPAIR 136 9.10e-01 -0.005630 9.50e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.30e-01 -0.005510 9.60e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 9.79e-01 0.004880 9.88e-01
GPCR LIGAND BINDING 244 8.96e-01 -0.004850 9.43e-01
RAP1 SIGNALLING 15 9.75e-01 -0.004610 9.86e-01
DISEASES OF IMMUNE SYSTEM 23 9.70e-01 0.004490 9.84e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 32 9.69e-01 0.004030 9.83e-01
VISUAL PHOTOTRANSDUCTION 60 9.58e-01 0.003920 9.76e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 9.83e-01 0.003780 9.90e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 179 9.48e-01 -0.002860 9.69e-01
INTRAFLAGELLAR TRANSPORT 50 9.72e-01 -0.002840 9.85e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 9.84e-01 -0.002430 9.90e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 9.89e-01 -0.002170 9.94e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 9.84e-01 -0.002080 9.90e-01
GOLGI TO ER RETROGRADE TRANSPORT 119 9.76e-01 0.001580 9.86e-01
DNA REPAIR 292 9.66e-01 -0.001430 9.82e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 9.92e-01 -0.001330 9.95e-01
CS DS DEGRADATION 14 9.93e-01 0.001320 9.95e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 25 9.92e-01 0.001220 9.95e-01
TRNA PROCESSING 105 9.84e-01 0.001160 9.90e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 9.96e-01 0.000709 9.97e-01
G ALPHA Q SIGNALLING EVENTS 146 9.90e-01 0.000586 9.95e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 9.97e-01 0.000473 9.97e-01


Detailed Gene set reports



SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
1049
set SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize 12
pANOVA 8.74e-05
s.dist -0.654
p.adjustANOVA 0.000959



Top enriched genes

Top 20 genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7834
Spcs3 -7739
Spcs1 -6626
Pcsk1 -6429
Sec11a -6393
Sec11c -5203
Grp -4619
Tcf7l2 -3842
Pax6 -3357
Ctnnb1 -2569
Gng13 -2173

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7834
Spcs3 -7739
Spcs1 -6626
Pcsk1 -6429
Sec11a -6393
Sec11c -5203
Grp -4619
Tcf7l2 -3842
Pax6 -3357
Ctnnb1 -2569
Gng13 -2173


INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION
438
set INCRETIN SYNTHESIS SECRETION AND INACTIVATION
setSize 13
pANOVA 5.27e-05
s.dist -0.648
p.adjustANOVA 0.000623



Top enriched genes

Top 20 genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7834
Spcs3 -7739
Spcs1 -6626
Pcsk1 -6429
Sec11a -6393
Sec11c -5203
Isl1 -4715
Grp -4619
Tcf7l2 -3842
Pax6 -3357
Ctnnb1 -2569
Gng13 -2173

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8284
Dpp4 -7834
Spcs3 -7739
Spcs1 -6626
Pcsk1 -6429
Sec11a -6393
Sec11c -5203
Isl1 -4715
Grp -4619
Tcf7l2 -3842
Pax6 -3357
Ctnnb1 -2569
Gng13 -2173


EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
303
set EUKARYOTIC TRANSLATION ELONGATION
setSize 87
pANOVA 1.86e-20
s.dist -0.575
p.adjustANOVA 4.36e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8141
Rplp0 -8066
Rpl5 -8040
Rpl27a -7806
Rps2 -7768
Eef1g -7647
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Rps3a1 -7247
Rpl15 -7145
Rps4x -7101
Rpl6 -6987
Eef1b2 -6800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8141
Rplp0 -8066
Rpl5 -8040
Rpl27a -7806
Rps2 -7768
Eef1g -7647
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Rps3a1 -7247
Rpl15 -7145
Rps4x -7101
Rpl6 -6987
Eef1b2 -6800
Rps6 -6778
Rpl9 -6764
Rpl24 -6731
Rps3 -6619
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Rpl11 -6314
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Rps13 -6050
Rps27l -5975
Eef1a1 -5772
Rps25 -5718
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Rps9 -5358
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Rps19 -4737
Rpsa -4551
Rps11 -4519
Rpl7a -4362
Rps10 -4314
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Rps15a -3370
Fau -3267
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Eef1d -1550
Rps21 -1427
Eef1a2 -1005
Eef2 -752
Rplp2 -429
Rpl36 -165
Rpl37 145
Rpl10 514
Rpl12 951
Rpl38 1302
Rps28 2422
Rps29 4006


GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
371
set GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
setSize 31
pANOVA 8.89e-08
s.dist -0.555
p.adjustANOVA 2.57e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8066
Hnrnpdl -7924
Rap1b -7871
Ppia -7845
Hspa9 -7462
Rala -7435
Hnrnpa2b1 -7378
Pdcd4 -6988
Mtap -6818
Psme2 -6584
Lcp1 -5846
Capza1 -5795
Gsto1 -5545
Snrpa1 -5224
Cnn2 -5021
Pak2 -4999
Hnrnpf -4672
Taldo1 -3813

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8066
Hnrnpdl -7924
Rap1b -7871
Ppia -7845
Hspa9 -7462
Rala -7435
Hnrnpa2b1 -7378
Pdcd4 -6988
Mtap -6818
Psme2 -6584
Lcp1 -5846
Capza1 -5795
Gsto1 -5545
Snrpa1 -5224
Cnn2 -5021
Pak2 -4999
Hnrnpf -4672
Taldo1 -3813
Sod2 -3755
Sod1 -3215
Cfl1 -3018
Aip -2618
Pitpna -1698
Msn -1261
Arf1 -564
Bola2 -8
Anxa2 509
Lmnb1 1473
Mif 4007


ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
28
set ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
setSize 59
pANOVA 1.92e-13
s.dist -0.553
p.adjustANOVA 1.25e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Eif2s2 -8324
Eif4a2 -8274
Eif3j2 -8206
Eif3e -8202
Eif4e -8156
Eif2s1 -8079
Eif3m -8002
Rps2 -7768
Rps24 -7591
Pabpc1 -7327
Rps3a1 -7247
Eif3h -7126
Rps4x -7101
Rps6 -6778
Eif1ax -6714
Eif2s3x -6648
Rps3 -6619
Rps8 -6582

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Eif2s2 -8324
Eif4a2 -8274
Eif3j2 -8206
Eif3e -8202
Eif4e -8156
Eif2s1 -8079
Eif3m -8002
Rps2 -7768
Rps24 -7591
Pabpc1 -7327
Rps3a1 -7247
Eif3h -7126
Rps4x -7101
Rps6 -6778
Eif1ax -6714
Eif2s3x -6648
Rps3 -6619
Rps8 -6582
Rps23 -6540
Rps27a -6495
Rps14 -6141
Rps13 -6050
Eif3a -6011
Rps27l -5975
Eif4b -5755
Rps25 -5718
Rps9 -5358
Eif3g -5313
Rps16 -5184
Rps20 -5080
Rps19 -4737
Rpsa -4551
Rps11 -4519
Rps10 -4314
Eif4a1 -4206
Eif3j1 -4145
Rps26 -3865
Rps17 -3848
Rps27 -3639
Rps15a -3370
Eif4ebp1 -3362
Fau -3267
Rps5 -3041
Eif3c -2718
Eif3k -2431
Eif3d -2344
Rps15 -2201
Rps12 -1815
Eif3f -1745
Rps21 -1427
Eif3i 284
Eif4h 1596
Eif3l 2389
Rps28 2422
Eif3b 3053
Eif4g1 3969
Rps29 4006


EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION
304
set EUKARYOTIC TRANSLATION INITIATION
setSize 114
pANOVA 3.62e-24
s.dist -0.549
p.adjustANOVA 2.12e-21



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Eif5b -8297
Rpl30 -8293
Eif4a2 -8274
Eif5 -8213
Eif3j2 -8206
Eif3e -8202
Eif4e -8156
Rpl22l1 -8141
Eif2s1 -8079
Rplp0 -8066
Rpl5 -8040
Eif3m -8002
Rpl27a -7806
Rps2 -7768
Rpl36a -7624
Rps24 -7591

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Eif5b -8297
Rpl30 -8293
Eif4a2 -8274
Eif5 -8213
Eif3j2 -8206
Eif3e -8202
Eif4e -8156
Rpl22l1 -8141
Eif2s1 -8079
Rplp0 -8066
Rpl5 -8040
Eif3m -8002
Rpl27a -7806
Rps2 -7768
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Pabpc1 -7327
Rps3a1 -7247
Rpl15 -7145
Eif3h -7126
Rps4x -7101
Rpl6 -6987
Eif2b3 -6845
Rps6 -6778
Rpl9 -6764
Rpl24 -6731
Eif1ax -6714
Eif2s3x -6648
Rps3 -6619
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Rpl11 -6314
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Rps13 -6050
Eif3a -6011
Rps27l -5975
Eif4b -5755
Rps25 -5718
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Rps9 -5358
Eif3g -5313
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Rps19 -4737
Rpsa -4551
Rps11 -4519
Rpl7a -4362
Rps10 -4314
Eif4a1 -4206
Eif3j1 -4145
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Rps15a -3370
Eif4ebp1 -3362
Fau -3267
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Eif3c -2718
Rplp1 -2691
Rpl8 -2622
Eif2b5 -2578
Eif3k -2431
Eif3d -2344
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Eif3f -1745
Rps21 -1427
Rplp2 -429
Rpl36 -165
Rpl37 145
Eif3i 284
Rpl10 514
Rpl12 951
Rpl38 1302
Eif4h 1596
Eif2b4 2120
Eif3l 2389
Rps28 2422
Eif2b1 2549
Eif3b 3053
Eif4g1 3969
Rps29 4006
Eif2b2 6854


SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
1007
set SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize 106
pANOVA 4.81e-22
s.dist -0.542
p.adjustANOVA 1.45e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Spcs2 -8284
Rpl22l1 -8141
Rplp0 -8066
Rpl5 -8040
Srp54a -7879
Rpl27a -7806
Rps2 -7768
Spcs3 -7739
Rpl36a -7624
Srp19 -7606
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Ssr3 -7313
Rps3a1 -7247

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Spcs2 -8284
Rpl22l1 -8141
Rplp0 -8066
Rpl5 -8040
Srp54a -7879
Rpl27a -7806
Rps2 -7768
Spcs3 -7739
Rpl36a -7624
Srp19 -7606
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Ssr3 -7313
Rps3a1 -7247
Ssr1 -7167
Rpl15 -7145
Rps4x -7101
Rpl6 -6987
Rps6 -6778
Rpl9 -6764
Sec61g -6747
Rpl24 -6731
Srp14 -6719
Spcs1 -6626
Rps3 -6619
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Sec11a -6393
Rpl11 -6314
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Srp9 -6063
Rps13 -6050
Rps27l -5975
Rps25 -5718
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Rps9 -5358
Sec11c -5203
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Rps19 -4737
Rpsa -4551
Rps11 -4519
Rpl7a -4362
Rps10 -4314
Rpn1 -4191
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Rps15a -3370
Fau -3267
Tram1 -3222
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Sec61b -2933
Rpl39 -2737
Srp72 -2721
Ssr4 -2693
Rplp1 -2691
Rpl8 -2622
Ssr2 -2440
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Rps21 -1427
Rplp2 -429
Rpn2 -246
Rpl36 -165
Srprb 131
Rpl37 145
Ddost 192
Rpl10 514
Rpl12 951
Rpl38 1302
Sec61a2 1781
Rps28 2422
Srpr 2709
Rps29 4006
Srp68 6072
Sec61a1 7338


RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
837
set RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize 94
pANOVA 2.31e-19
s.dist -0.537
p.adjustANOVA 3.86e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Rpl30 -8293
Rpl22l1 -8141
Eif2s1 -8079
Rplp0 -8066
Rpl5 -8040
Rpl27a -7806
Cebpg -7782
Rps2 -7768
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Rps3a1 -7247
Rpl15 -7145
Rps4x -7101

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
Rpl30 -8293
Rpl22l1 -8141
Eif2s1 -8079
Rplp0 -8066
Rpl5 -8040
Rpl27a -7806
Cebpg -7782
Rps2 -7768
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Rps3a1 -7247
Rpl15 -7145
Rps4x -7101
Rpl6 -6987
Rps6 -6778
Rpl9 -6764
Rpl24 -6731
Eif2s3x -6648
Rps3 -6619
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Asns -6350
Rpl11 -6314
Impact -6270
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Rps13 -6050
Rps27l -5975
Rps25 -5718
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Atf2 -5437
Rps9 -5358
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Rps19 -4737
Rpsa -4551
Rps11 -4519
Rpl7a -4362
Rps10 -4314
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Rps15a -3370
Fau -3267
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Rps21 -1427
Atf3 -1057
Rplp2 -429
Atf4 -352
Rpl36 -165
Rpl37 145
Ddit3 207
Rpl10 514
Rpl12 951
Rpl38 1302
Rps28 2422
Rps29 4006
Cebpb 6857
Eif2ak4 8309
Gcn1 8499


SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN

SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
1048
set SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
setSize 12
pANOVA 0.00155
s.dist -0.528
p.adjustANOVA 0.0119



Top enriched genes

Top 20 genes
GeneID Gene Rank
Spcs2 -8284
Pla2g7 -8192
Spcs3 -7739
Spcs1 -6626
Pcsk1 -6429
Sec11a -6393
Bche -5750
Sec11c -5203
Igf1 -3521
Klf4 -2316
Crhr2 3746
Ache 4463

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Spcs2 -8284
Pla2g7 -8192
Spcs3 -7739
Spcs1 -6626
Pcsk1 -6429
Sec11a -6393
Bche -5750
Sec11c -5203
Igf1 -3521
Klf4 -2316
Crhr2 3746
Ache 4463


ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY
35
set ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize 10
pANOVA 0.00491
s.dist 0.514
p.adjustANOVA 0.0302



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adcy6 8343
Adcy1 7876
Adcy4 7558
Adcy3 6270
Adcy5 6103
Adcy9 6004
Adcy7 5768
Gnal 1960
Adcy2 -1367
Adcy8 -3914

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8343
Adcy1 7876
Adcy4 7558
Adcy3 6270
Adcy5 6103
Adcy9 6004
Adcy7 5768
Gnal 1960
Adcy2 -1367
Adcy8 -3914


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
1030
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 3.4e-06
s.dist -0.498
p.adjustANOVA 5.85e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ube2b -8167
Ube2d2a -8123
Ube2l3 -8107
Ube2d1 -8100
Ube2e1 -8074
Ube2k -7794
Ube2a -7638
Ube2w -7489
Ube2e3 -7471
Ube2r2 -7384
Ube2t -7149
Ube2g1 -7107
Ube2q2 -6665
Rps27a -6495
Uchl3 -6205
Uba52 -3960
Otulin -3806
Ube2s -3359
Uba6 -2871
Usp9x -2098

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2b -8167
Ube2d2a -8123
Ube2l3 -8107
Ube2d1 -8100
Ube2e1 -8074
Ube2k -7794
Ube2a -7638
Ube2w -7489
Ube2e3 -7471
Ube2r2 -7384
Ube2t -7149
Ube2g1 -7107
Ube2q2 -6665
Rps27a -6495
Uchl3 -6205
Uba52 -3960
Otulin -3806
Ube2s -3359
Uba6 -2871
Usp9x -2098
Ubb -1705
Cdc34 -1533
Usp7 -413
Ubc 176
Ube2z 993
Ube2h 1794
Usp5 1843
Uba1 2293
Ube2g2 5693


COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
171
set COMPLEX I BIOGENESIS
setSize 56
pANOVA 1.5e-10
s.dist -0.495
p.adjustANOVA 8.35e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
Ndufaf2 -8036
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
mt-Nd2 -7691
Ndufa10 -7690
Ndufb4 -7616
Ndufaf1 -7515
mt-Nd4 -7348
Ndufaf5 -7171
Ndufb5 -7049
mt-Nd6 -7046
Ndufb6 -6773
mt-Nd5 -6712
Ndufc1 -6489
Nubpl -6400
Ndufa8 -6288

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
Ndufaf2 -8036
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
mt-Nd2 -7691
Ndufa10 -7690
Ndufb4 -7616
Ndufaf1 -7515
mt-Nd4 -7348
Ndufaf5 -7171
Ndufb5 -7049
mt-Nd6 -7046
Ndufb6 -6773
mt-Nd5 -6712
Ndufc1 -6489
Nubpl -6400
Ndufa8 -6288
Ndufa9 -6258
Ndufs2 -6093
Ndufb3 -6047
Ndufb9 -5882
Ndufa12 -5878
Ndufa5 -5746
Ndufs5 -5271
Ndufb2 -5052
Ndufs6 -5003
Ndufs1 -4858
Ndufb11 -4703
Ndufb8 -4574
Tmem126b -4549
Ndufaf6 -4409
Ndufa6 -3969
Ndufs8 -3711
Ndufs3 -3557
Ndufaf7 -2652
Ndufv1 -2446
Ndufa1 -2342
Ndufb1 -1848
Timmdc1 -1652
Ndufab1 -1622
Ndufaf3 -1006
Ndufa7 -922
Ndufb7 -677
Ndufa13 -112
Ndufb10 93
Ndufa2 115
Ndufa11 761
Ndufv3 1316
Acad9 1432
Ndufs7 2959
Ndufa3 3432
Ecsit 5455
Tmem186 5506


CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
125
set CD28 DEPENDENT VAV1 PATHWAY
setSize 11
pANOVA 0.00494
s.dist -0.489
p.adjustANOVA 0.0303



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cdc42 -8238
Pak1 -8116
Pak3 -6854
Rac1 -5803
Cd86 -5012
Pak2 -4999
Cd80 -2882
Grb2 -2784
Lck -1794
Fyn 1001
Vav1 1149

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cdc42 -8238
Pak1 -8116
Pak3 -6854
Rac1 -5803
Cd86 -5012
Pak2 -4999
Cd80 -2882
Grb2 -2784
Lck -1794
Fyn 1001
Vav1 1149


TERMINATION OF O GLYCAN BIOSYNTHESIS

TERMINATION OF O GLYCAN BIOSYNTHESIS
1058
set TERMINATION OF O GLYCAN BIOSYNTHESIS
setSize 10
pANOVA 0.00748
s.dist 0.488
p.adjustANOVA 0.0421



Top enriched genes

Top 20 genes
GeneID Gene Rank
St3gal3 7969
St6galnac2 7809
St3gal1 7172
St3gal2 5158
Muc3a 5143
St6galnac4 5022
St6galnac3 3407
Muc6 2068
St3gal4 -442
St6gal1 -847

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
St3gal3 7969
St6galnac2 7809
St3gal1 7172
St3gal2 5158
Muc3a 5143
St6galnac4 5022
St6galnac3 3407
Muc6 2068
St3gal4 -442
St6gal1 -847


CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING
189
set CRMPS IN SEMA3A SIGNALING
setSize 16
pANOVA 0.000719
s.dist 0.488
p.adjustANOVA 0.00633



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dpysl5 8431
Plxna1 8242
Plxna3 7928
Dpysl4 7605
Fes 7245
Plxna2 6985
Plxna4 6955
Crmp1 6150
Nrp1 6030
Dpysl2 2869
Cdk5 2570
Fyn 1001
Gsk3b -138
Cdk5r1 -305
Dpysl3 -1629
Sema3a -2039

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dpysl5 8431
Plxna1 8242
Plxna3 7928
Dpysl4 7605
Fes 7245
Plxna2 6985
Plxna4 6955
Crmp1 6150
Nrp1 6030
Dpysl2 2869
Cdk5 2570
Fyn 1001
Gsk3b -138
Cdk5r1 -305
Dpysl3 -1629
Sema3a -2039


SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM
909
set SELENOAMINO ACID METABOLISM
setSize 109
pANOVA 2.85e-18
s.dist -0.483
p.adjustANOVA 3.71e-16



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8141
Hnmt -8090
Rplp0 -8066
Rpl5 -8040
Rpl27a -7806
Rps2 -7768
Rars -7667
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Ahcy -7587
Aimp1 -7569
Rpl26 -7528
Dars -7464
Rpl3 -7423

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8141
Hnmt -8090
Rplp0 -8066
Rpl5 -8040
Rpl27a -7806
Rps2 -7768
Rars -7667
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Ahcy -7587
Aimp1 -7569
Rpl26 -7528
Dars -7464
Rpl3 -7423
Rps3a1 -7247
Sars -7189
Rpl15 -7145
Rps4x -7101
Rpl6 -6987
Rps6 -6778
Rpl9 -6764
Rpl24 -6731
Rps3 -6619
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Rpl11 -6314
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Rps13 -6050
Rps27l -5975
Rps25 -5718
Pstk -5613
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Rps9 -5358
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Eprs -5045
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Papss2 -4778
Rps19 -4737
Sephs2 -4674
Rpsa -4551
Rps11 -4519
Rpl7a -4362
Rps10 -4314
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Kars -3398
Rps15a -3370
Fau -3267
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Papss1 -2803
Rpl39 -2737
Rplp1 -2691
Gsr -2684
Rpl8 -2622
Cbs -2611
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Rps21 -1427
Lars -1221
Aimp2 -461
Inmt -456
Rplp2 -429
Rpl36 -165
Rpl37 145
Rpl10 514
Rpl12 951
Eefsec 1273
Rpl38 1302
Scly 1988
Sepsecs 2320
Rps28 2422
Cth 2453
Txnrd1 3664
Rps29 4006
Iars 5545
Gnmt 6059
Qars 6325
Mars1 6721
Secisbp2 8325


APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION
66
set APOPTOSIS INDUCED DNA FRAGMENTATION
setSize 10
pANOVA 0.00903
s.dist -0.477
p.adjustANOVA 0.0485



Top enriched genes

Top 20 genes
GeneID Gene Rank
H1f2 -8340
Casp3 -8259
Hmgb1 -8226
H1f0 -8175
Hmgb2 -7878
H1f4 -5807
Kpna1 -5448
Kpnb1 1223
Dffb 5687
Dffa 5989

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H1f2 -8340
Casp3 -8259
Hmgb1 -8226
H1f0 -8175
Hmgb2 -7878
H1f4 -5807
Kpna1 -5448
Kpnb1 1223
Dffb 5687
Dffa 5989


PROTEIN METHYLATION

PROTEIN METHYLATION
751
set PROTEIN METHYLATION
setSize 17
pANOVA 0.000785
s.dist -0.47
p.adjustANOVA 0.00681



Top enriched genes

Top 20 genes
GeneID Gene Rank
Calm1 -8268
Hspa8 -7919
Rps2 -7768
Eef1akmt2 -7275
Kin -7228
Vcpkmt -7225
Vcp -6370
Eef1a1 -5772
Etfb -5388
Etfbkmt -5260
Eef1akmt1 -4743
Camkmt -2777
Mettl21a -1900
Eef2 -752
Eef2kmt 2336
Prmt3 5164
Mettl22 5398

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calm1 -8268
Hspa8 -7919
Rps2 -7768
Eef1akmt2 -7275
Kin -7228
Vcpkmt -7225
Vcp -6370
Eef1a1 -5772
Etfb -5388
Etfbkmt -5260
Eef1akmt1 -4743
Camkmt -2777
Mettl21a -1900
Eef2 -752
Eef2kmt 2336
Prmt3 5164
Mettl22 5398


TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
1099
set TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize 11
pANOVA 0.00839
s.dist -0.459
p.adjustANOVA 0.0461



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsp90b1 -8325
Tlr3 -8233
Ctsl -7964
Ctss -7943
Ctsb -6536
Lgmn -5798
Tlr7 -1935
Ctsk -1464
Cnpy3 1852
Tlr9 2356
Unc93b1 2491

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsp90b1 -8325
Tlr3 -8233
Ctsl -7964
Ctss -7943
Ctsb -6536
Lgmn -5798
Tlr7 -1935
Ctsk -1464
Cnpy3 1852
Tlr9 2356
Unc93b1 2491


RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
834
set RESPIRATORY ELECTRON TRANSPORT
setSize 102
pANOVA 1.34e-15
s.dist -0.458
p.adjustANOVA 1.21e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
mt-Co1 -8117
Ndufaf2 -8036
Uqcrc2 -7974
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
mt-Nd2 -7691
Ndufa10 -7690
Cox20 -7655
Ndufb4 -7616
Ndufaf1 -7515
Cox7a2l -7370
Etfa -7356
mt-Nd4 -7348
mt-Co2 -7285
mt-Cytb -7188

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
mt-Co1 -8117
Ndufaf2 -8036
Uqcrc2 -7974
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
mt-Nd2 -7691
Ndufa10 -7690
Cox20 -7655
Ndufb4 -7616
Ndufaf1 -7515
Cox7a2l -7370
Etfa -7356
mt-Nd4 -7348
mt-Co2 -7285
mt-Cytb -7188
Ndufaf5 -7171
Sco1 -7112
Ndufb5 -7049
mt-Nd6 -7046
mt-Co3 -7028
Cox7b -6990
Ndufb6 -6773
Ndufa4 -6744
Coq10b -6737
mt-Nd5 -6712
Ndufc1 -6489
Nubpl -6400
Ndufa8 -6288
Ndufa9 -6258
Cox16 -6207
Uqcrb -6105
Ndufs2 -6093
Ndufb3 -6047
Sdhc -5905
Ndufb9 -5882
Ndufa12 -5878
Ndufa5 -5746
Cox6c -5703
Etfb -5388
Ndufs5 -5271
Ndufb2 -5052
Ndufs6 -5003
Sdhd -4864
Ndufs1 -4858
Etfdh -4829
Ndufb11 -4703
Ndufb8 -4574
Surf1 -4552
Tmem126b -4549
Uqcrh -4432
Ndufaf6 -4409
Cox5a -4305
Cox7c -4253
Sdha -4022
Cox4i1 -3971
Ndufa6 -3969
Ndufs8 -3711
Ndufs3 -3557
Sdhb -3435
Sco2 -3311
Uqcrq -2949
Ndufaf7 -2652
Ndufv1 -2446
Cox14 -2445
Ndufa1 -2342
Ndufb1 -1848
Cox19 -1734
Timmdc1 -1652
Ndufab1 -1622
Cox6b1 -1294
Lrpprc -1274
Cox6a1 -1024
Ndufaf3 -1006
Ndufa7 -922
Uqcrfs1 -898
Ndufb7 -677
Uqcr10 -620
Ndufa13 -112
Ndufb10 93
Ndufa2 115
Cox5b 523
Coq10a 573
Cox8a 688
Ndufa11 761
Cyc1 765
Uqcr11 1036
Cox11 1132
Ndufv3 1316
Acad9 1432
Uqcrc1 1965
Ndufs7 2959
Ndufa3 3432
Ecsit 5455
Tmem186 5506
Cox18 6026
Taco1 6075
Trap1 6575


ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
40
set ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize 19
pANOVA 0.000594
s.dist -0.455
p.adjustANOVA 0.00531



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng11 -8252
P2ry12 -7451
Gng10 -7220
Gnai3 -7219
Gng12 -7193
Gnai1 -6304
Gnb4 -5408
Gngt2 -5362
Gnb1 -5114
Gng5 -4383
Gng2 -4118
Gng3 -4032
Gng4 -2468
Gng13 -2173
Gnb5 -453
Gnai2 477
Gng8 917
Gnb2 2170
Gng7 2566

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng11 -8252
P2ry12 -7451
Gng10 -7220
Gnai3 -7219
Gng12 -7193
Gnai1 -6304
Gnb4 -5408
Gngt2 -5362
Gnb1 -5114
Gng5 -4383
Gng2 -4118
Gng3 -4032
Gng4 -2468
Gng13 -2173
Gnb5 -453
Gnai2 477
Gng8 917
Gnb2 2170
Gng7 2566


REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
790
set REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
setSize 10
pANOVA 0.0138
s.dist 0.45
p.adjustANOVA 0.0684



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slit1 8421
Src 8036
Slit3 7063
Nell2 5337
Robo1 4327
Robo3 3267
Ntn1 3114
Dcc 2128
Robo2 1898
Slit2 -4402

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slit1 8421
Src 8036
Slit3 7063
Nell2 5337
Robo1 4327
Robo3 3267
Ntn1 3114
Dcc 2128
Robo2 1898
Slit2 -4402


SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION

SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
911
set SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
setSize 14
pANOVA 0.00379
s.dist 0.447
p.adjustANOVA 0.0249



Top enriched genes

Top 20 genes
GeneID Gene Rank
Plxna1 8242
Plxna3 7928
Tln1 7271
Fes 7245
Plxna2 6985
Plxna4 6955
Pip5k1c 6851
Nrp1 6030
Farp2 4925
Rras 1710
Fyn 1001
Sema3a -2039
Rnd1 -2788
Rac1 -5803

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Plxna1 8242
Plxna3 7928
Tln1 7271
Fes 7245
Plxna2 6985
Plxna4 6955
Pip5k1c 6851
Nrp1 6030
Farp2 4925
Rras 1710
Fyn 1001
Sema3a -2039
Rnd1 -2788
Rac1 -5803


REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
815
set REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize 17
pANOVA 0.00143
s.dist 0.447
p.adjustANOVA 0.0112



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mov10 8303
Src 8036
Tnrc6c 7552
Ago2 7472
Pml 7138
Ago3 7117
Ago1 7076
Ptpn11 6108
Cdk6 6065
Tnrc6a 5731
Tnrc6b 5465
Ccnd3 3485
Ccnd2 2989
Runx1 -2910
Ago4 -3818
Cbfb -4532
Ccnd1 -5131

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mov10 8303
Src 8036
Tnrc6c 7552
Ago2 7472
Pml 7138
Ago3 7117
Ago1 7076
Ptpn11 6108
Cdk6 6065
Tnrc6a 5731
Tnrc6b 5465
Ccnd3 3485
Ccnd2 2989
Runx1 -2910
Ago4 -3818
Cbfb -4532
Ccnd1 -5131


CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
190
set CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize 47
pANOVA 1.2e-07
s.dist -0.446
p.adjustANOVA 3.28e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Psmd8 -6421

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Psmd8 -6421
Mrc1 -5916
Psma7 -5400
Psmc5 -4628
Psmb4 -4130
Fcgr1 -3874
Psme3 -3372
Sem1 -3270
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Psmb6 -1711
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Psmd9 182
Psmf1 393
Mrc2 451
Psmd11 661
Psmb2 1247
Psmd4 1519
Psmc4 2323
Psmb11 2711
Psme4 3582
Psmb5 4171
Psmd3 7171


NEGATIVE REGULATION OF NOTCH4 SIGNALING

NEGATIVE REGULATION OF NOTCH4 SIGNALING
610
set NEGATIVE REGULATION OF NOTCH4 SIGNALING
setSize 54
pANOVA 1.46e-08
s.dist -0.446
p.adjustANOVA 5.5e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Fbxw7 -8219
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Rbx1 -6792
Psma1 -6696

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Fbxw7 -8219
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Rbx1 -6792
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Rps27a -6495
Psmd8 -6421
Ywhaz -6204
Psma7 -5400
Psmc5 -4628
Psmb4 -4130
Uba52 -3960
Psme3 -3372
Sem1 -3270
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Cul1 -2786
Psmb10 -2592
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 393
Psmd11 661
Psmb2 1247
Psmd4 1519
Psmc4 2323
Tacc3 2328
Psmb5 4171
Akt1 5806
Psmd3 7171
Notch4 7821


NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD
632
set NONSENSE MEDIATED DECAY NMD
setSize 109
pANOVA 9.02e-16
s.dist -0.446
p.adjustANOVA 9.49e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8141
Rplp0 -8066
Rpl5 -8040
Rbm8a -7969
Ppp2r2a -7843
Rpl27a -7806
Rps2 -7768
Ncbp2 -7698
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Pabpc1 -7327
Etf1 -7308
Rps3a1 -7247

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Rpl22l1 -8141
Rplp0 -8066
Rpl5 -8040
Rbm8a -7969
Ppp2r2a -7843
Rpl27a -7806
Rps2 -7768
Ncbp2 -7698
Rpl36a -7624
Rps24 -7591
Rpl29 -7590
Rpl26 -7528
Rpl3 -7423
Pabpc1 -7327
Etf1 -7308
Rps3a1 -7247
Ppp2ca -7194
Rpl15 -7145
Rps4x -7101
Pnrc2 -7015
Rpl6 -6987
Rps6 -6778
Rpl9 -6764
Rpl24 -6731
Magoh -6642
Rps3 -6619
Upf3b -6617
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Rpl11 -6314
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Rps13 -6050
Rps27l -5975
Rps25 -5718
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Rps9 -5358
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Rps19 -4737
Rpsa -4551
Rps11 -4519
Rpl7a -4362
Rps10 -4314
Upf2 -4067
Magohb -4000
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Rps15a -3370
Fau -3267
Rpl37a -3095
Rps5 -3041
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Upf3a -2326
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Eif4a3 -1511
Rps21 -1427
Rplp2 -429
Rpl36 -165
Rpl37 145
Gspt2 283
Rpl10 514
Ppp2r1a 824
Rnps1 916
Rpl12 951
Rpl38 1302
Gspt1 2174
Rps28 2422
Ncbp1 3139
Eif4g1 3969
Rps29 4006
Smg8 4278
Smg7 5010
Smg6 5352
Dcp1a 5376
Smg9 6453
Casc3 7238
Smg1 7531
Upf1 7910
Smg5 8469


TRIGLYCERIDE CATABOLISM

TRIGLYCERIDE CATABOLISM
1140
set TRIGLYCERIDE CATABOLISM
setSize 14
pANOVA 0.00425
s.dist -0.441
p.adjustANOVA 0.0275



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fabp7 -8292
Prkacb -7640
Fabp5 -7221
Ppp1cb -7098
Abhd5 -6324
Gpd2 -5443
Ppp1ca -4020
Ppp1cc -3616
Fabp3 -3553
Cav1 -3345
Plin3 -3306
Mgll 751
Lipe 2686
Prkaca 5710

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fabp7 -8292
Prkacb -7640
Fabp5 -7221
Ppp1cb -7098
Abhd5 -6324
Gpd2 -5443
Ppp1ca -4020
Ppp1cc -3616
Fabp3 -3553
Cav1 -3345
Plin3 -3306
Mgll 751
Lipe 2686
Prkaca 5710


REGULATION OF EXPRESSION OF SLITS AND ROBOS

REGULATION OF EXPRESSION OF SLITS AND ROBOS
791
set REGULATION OF EXPRESSION OF SLITS AND ROBOS
setSize 161
pANOVA 4.97e-22
s.dist -0.441
p.adjustANOVA 1.45e-19



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Psmc1 -8281
Psmd12 -8214
Rpl22l1 -8141
Psma6 -8083
Rplp0 -8066
Rpl5 -8040
Psma3 -8008
Rbm8a -7969
Psmc6 -7952
Eloc -7935
Rpl27a -7806
Rps2 -7768
Ncbp2 -7698
Rpl36a -7624
Psmb1 -7592
Rps24 -7591

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Rps7 -8344
Rpl35a -8326
Rpl30 -8293
Psmc1 -8281
Psmd12 -8214
Rpl22l1 -8141
Psma6 -8083
Rplp0 -8066
Rpl5 -8040
Psma3 -8008
Rbm8a -7969
Psmc6 -7952
Eloc -7935
Rpl27a -7806
Rps2 -7768
Ncbp2 -7698
Rpl36a -7624
Psmb1 -7592
Rps24 -7591
Rpl29 -7590
Psmd14 -7555
Rpl26 -7528
Psmd6 -7433
Rpl3 -7423
Psma2 -7377
Psmb7 -7343
Pabpc1 -7327
Etf1 -7308
Rps3a1 -7247
Psmd10 -7234
Psma4 -7157
Rpl15 -7145
Psma5 -7119
Rps4x -7101
Psmd1 -7050
Rpl6 -6987
Cul2 -6925
Psmc2 -6811
Psmb8 -6795
Rbx1 -6792
Rps6 -6778
Rpl9 -6764
Rpl24 -6731
Psma1 -6696
Psmd7 -6678
Magoh -6642
Rps3 -6619
Upf3b -6617
Rpl7 -6613
Psme2 -6584
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Psmd8 -6421
Rpl11 -6314
Rpl14 -6262
Rpl4 -6223
Rpl22 -6168
Rps14 -6141
Rps13 -6050
Rps27l -5975
Rps25 -5718
Rpl23a -5554
Rpl18a -5540
Rpl23 -5442
Psma7 -5400
Rps9 -5358
Rpl31 -5187
Rps16 -5184
Rps20 -5080
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Rpl10a -4803
Rps19 -4737
Isl1 -4715
Psmc5 -4628
Rpsa -4551
Rps11 -4519
Slit2 -4402
Rpl7a -4362
Rps10 -4314
Psmb4 -4130
Upf2 -4067
Magohb -4000
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Rpl19 -3712
Rpl32 -3656
Rps27 -3639
Psme3 -3372
Rps15a -3370
Sem1 -3270
Fau -3267
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Rpl37a -3095
Elob -3074
Usp33 -3067
Rps5 -3041
Psmb9 -3039
Rpl34 -3010
Rpl18 -2938
Rpl39 -2737
Rplp1 -2691
Rpl8 -2622
Psmb10 -2592
Upf3a -2326
Rps15 -2201
Rpl13 -1947
Rpl35 -1857
Rps12 -1815
Psmb6 -1711
Ubb -1705
Eif4a3 -1511
Psmd13 -1434
Rps21 -1427
Psmb3 -868
Rplp2 -429
Rpl36 -165
Psmd2 -105
Rpl37 145
Ubc 176
Psmd9 182
Gspt2 283
Psmf1 393
Rpl10 514
Psmd11 661
Rnps1 916
Rpl12 951
Psmb2 1247
Lhx9 1292
Rpl38 1302
Psmd4 1519
Robo2 1898
Dag1 1968
Gspt1 2174
Psmc4 2323
Rps28 2422
Lhx2 2616
Psmb11 2711
Ncbp1 3139
Robo3 3267
Psme4 3582
Eif4g1 3969
Rps29 4006
Psmb5 4171
Robo1 4327
Col4a5 5231
Msi1 5486
Ldb1 6869
Psmd3 7171
Casc3 7238
Zswim8 8269
Slit1 8421


CRISTAE FORMATION

CRISTAE FORMATION
188
set CRISTAE FORMATION
setSize 31
pANOVA 2.3e-05
s.dist -0.439
p.adjustANOVA 0.000306



Top enriched genes

Top 20 genes
GeneID Gene Rank
Apoo -8251
Atp5pb -7848
Mtx2 -7791
Atp5c1 -7618
Hspa9 -7462
Dmac2l -7416
mt-Atp6 -7410
Atp5h -7400
Micos10 -7239
Atp5b -6701
Atp5a1 -6246
Atp5j -6240
Atp5l -5922
Atp5g3 -5787
Immt -5462
Apool -5075
Atp5o -4857
Chchd3 -4146
Atp5j2 -3789
Tmem11 -3632

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Apoo -8251
Atp5pb -7848
Mtx2 -7791
Atp5c1 -7618
Hspa9 -7462
Dmac2l -7416
mt-Atp6 -7410
Atp5h -7400
Micos10 -7239
Atp5b -6701
Atp5a1 -6246
Atp5j -6240
Atp5l -5922
Atp5g3 -5787
Immt -5462
Apool -5075
Atp5o -4857
Chchd3 -4146
Atp5j2 -3789
Tmem11 -3632
Atp5e -3319
Samm50 -2911
Chchd6 -2414
Micos13 -2255
mt-Atp8 -20
Atp5d 1601
Mtx1 3627
Dnajc11 3699
Atp5g1 4677
Atp5k 5443
Atp5g2 6507


RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
835
set RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize 125
pANOVA 2.82e-17
s.dist -0.438
p.adjustANOVA 3.3e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
mt-Co1 -8117
Ndufaf2 -8036
Uqcrc2 -7974
Atp5pb -7848
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
mt-Nd2 -7691
Ndufa10 -7690
Ucp3 -7686
Cox20 -7655
Atp5c1 -7618
Ndufb4 -7616
Ndufaf1 -7515
Dmac2l -7416
mt-Atp6 -7410

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8327
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
mt-Co1 -8117
Ndufaf2 -8036
Uqcrc2 -7974
Atp5pb -7848
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
mt-Nd2 -7691
Ndufa10 -7690
Ucp3 -7686
Cox20 -7655
Atp5c1 -7618
Ndufb4 -7616
Ndufaf1 -7515
Dmac2l -7416
mt-Atp6 -7410
Atp5h -7400
Cox7a2l -7370
Etfa -7356
mt-Nd4 -7348
mt-Co2 -7285
mt-Cytb -7188
Ndufaf5 -7171
Sco1 -7112
Ndufb5 -7049
mt-Nd6 -7046
mt-Co3 -7028
Slc25a14 -7019
Cox7b -6990
Ndufb6 -6773
Ndufa4 -6744
Coq10b -6737
mt-Nd5 -6712
Atp5b -6701
Ndufc1 -6489
Nubpl -6400
Ndufa8 -6288
Ndufa9 -6258
Atp5a1 -6246
Atp5j -6240
Cox16 -6207
Uqcrb -6105
Ndufs2 -6093
Ndufb3 -6047
Atp5l -5922
Sdhc -5905
Ndufb9 -5882
Ndufa12 -5878
Atp5g3 -5787
Ndufa5 -5746
Cox6c -5703
Etfb -5388
Ndufs5 -5271
Ndufb2 -5052
Ndufs6 -5003
Sdhd -4864
Ndufs1 -4858
Atp5o -4857
Etfdh -4829
Ndufb11 -4703
Ndufb8 -4574
Surf1 -4552
Tmem126b -4549
Uqcrh -4432
Ndufaf6 -4409
Cox5a -4305
Cox7c -4253
Sdha -4022
Cox4i1 -3971
Ndufa6 -3969
Atp5j2 -3789
Ndufs8 -3711
Ndufs3 -3557
Sdhb -3435
Atp5e -3319
Sco2 -3311
Uqcrq -2949
Ndufaf7 -2652
Ndufv1 -2446
Cox14 -2445
Ndufa1 -2342
Pm20d1 -1959
Ndufb1 -1848
Cox19 -1734
Timmdc1 -1652
Ndufab1 -1622
Cox6b1 -1294
Lrpprc -1274
Cox6a1 -1024
Ndufaf3 -1006
Ndufa7 -922
Uqcrfs1 -898
Ndufb7 -677
Uqcr10 -620
Ndufa13 -112
mt-Atp8 -20
Ndufb10 93
Ndufa2 115
Cox5b 523
Coq10a 573
Cox8a 688
Ndufa11 761
Cyc1 765
Uqcr11 1036
Cox11 1132
Ndufv3 1316
Acad9 1432
Atp5d 1601
Uqcrc1 1965
Ndufs7 2959
Ndufa3 3432
Atp5g1 4677
Atp5k 5443
Ecsit 5455
Tmem186 5506
Cox18 6026
Taco1 6075
Atp5g2 6507
Trap1 6575
Slc25a27 7257
Ucp2 7420


NRAGE SIGNALS DEATH THROUGH JNK

NRAGE SIGNALS DEATH THROUGH JNK
644
set NRAGE SIGNALS DEATH THROUGH JNK
setSize 55
pANOVA 2.09e-08
s.dist 0.437
p.adjustANOVA 7.63e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Obscn 8445
Vav2 8423
Arhgef10 8316
Mcf2l 8253
Plekhg2 8207
Arhgef5 8173
Plekhg5 8020
Akap13 7920
Arhgef4 7919
Arhgef18 7879
Kalrn 7815
Arhgef7 7761
Arhgef17 7754
Arhgef2 7731
Arhgef1 7709
Trio 7554
Arhgef11 7503
Abr 7479
Rasgrf2 7289
Prex1 6987

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Obscn 8445
Vav2 8423
Arhgef10 8316
Mcf2l 8253
Plekhg2 8207
Arhgef5 8173
Plekhg5 8020
Akap13 7920
Arhgef4 7919
Arhgef18 7879
Kalrn 7815
Arhgef7 7761
Arhgef17 7754
Arhgef2 7731
Arhgef1 7709
Trio 7554
Arhgef11 7503
Abr 7479
Rasgrf2 7289
Prex1 6987
Arhgef40 6957
Arhgef19 6752
Fgd1 6592
Arhgef10l 6441
Itsn1 6345
Arhgef12 6278
Arhgef6 6116
Arhgef33 5616
Fgd2 5476
Tiam1 5244
Arhgef37 4214
Tiam2 3403
Maged1 2776
Arhgef16 2421
Arhgef26 1975
Fgd3 1899
Ngf 1659
Arhgef3 1641
Vav1 1149
Aatf 1000
Gna13 947
Arhgef9 447
Net1 121
Sos1 -264
Fgd4 -322
Bad -378
Bcl2l11 -1041
Vav3 -1069
Ngef -1236
Sos2 -1968
Arhgef15 -3897
Ngfr -5353
Mapk8 -5712
Rac1 -5803
Mcf2 -6586


SCF SKP2 MEDIATED DEGRADATION OF P27 P21

SCF SKP2 MEDIATED DEGRADATION OF P27 P21
906
set SCF SKP2 MEDIATED DEGRADATION OF P27 P21
setSize 59
pANOVA 6.58e-09
s.dist -0.437
p.adjustANOVA 2.85e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Ccne2 -7699
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Skp1 -8308
Psmc1 -8281
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Ccne2 -7699
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Rps27a -6495
Psmd8 -6421
Ccna2 -5415
Psma7 -5400
Ccnd1 -5131
Psmc5 -4628
Psmb4 -4130
Uba52 -3960
Cdkn1a -3492
Psme3 -3372
Cks1b -3320
Sem1 -3270
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Cdkn1b -2999
Cdk4 -2980
Cul1 -2786
Psmb10 -2592
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Psmb3 -868
Ccne1 -728
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 393
Psmd11 661
Psmb2 1247
Psmd4 1519
Psmc4 2323
Skp2 4008
Ccna1 4014
Psmb5 4171
Cdk2 4827
Psmd3 7171


DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS

DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
217
set DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
setSize 59
pANOVA 8e-09
s.dist -0.434
p.adjustANOVA 3.23e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Erlec1 -8118
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Derl2 -7847
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Erlec1 -8118
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Derl2 -7847
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Rps27a -6495
Rnf5 -6487
Psmd8 -6421
Vcp -6370
Psma7 -5400
Psmc5 -4628
Derl1 -4452
Psmb4 -4130
Uba52 -3960
Psme3 -3372
Sem1 -3270
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Erlin1 -2579
Rnf185 -1770
Os9 -1766
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Derl3 -1361
Psmb3 -868
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 393
Psmd11 661
Psmb2 1247
Psmd4 1519
Psmc4 2323
Sel1l 2625
Psmb11 2711
Erlin2 3055
Psme4 3582
Psmb5 4171
Psmd3 7171


SIGNALING BY LEPTIN

SIGNALING BY LEPTIN
963
set SIGNALING BY LEPTIN
setSize 10
pANOVA 0.0178
s.dist 0.433
p.adjustANOVA 0.0824



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sh2b1 8211
Stat3 6485
Ptpn11 6108
Stat5b 4875
Irs1 4502
Jak2 4364
Irs2 3402
Stat5a 2969
Socs3 -685
Lepr -2482

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sh2b1 8211
Stat3 6485
Ptpn11 6108
Stat5b 4875
Irs1 4502
Jak2 4364
Irs2 3402
Stat5a 2969
Socs3 -685
Lepr -2482


INTERLEUKIN 12 SIGNALING

INTERLEUKIN 12 SIGNALING
469
set INTERLEUKIN 12 SIGNALING
setSize 37
pANOVA 5.34e-06
s.dist -0.432
p.adjustANOVA 8.61e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8066
Hnrnpdl -7924
Rap1b -7871
Ppia -7845
Hspa9 -7462
Rala -7435
Hnrnpa2b1 -7378
Pdcd4 -6988
Mtap -6818
Psme2 -6584
Lcp1 -5846
Capza1 -5795
Gsto1 -5545
Snrpa1 -5224
Cnn2 -5021
Pak2 -4999
Hnrnpf -4672
P4hb -4375

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tcp1 -8258
Cdc42 -8238
Rplp0 -8066
Hnrnpdl -7924
Rap1b -7871
Ppia -7845
Hspa9 -7462
Rala -7435
Hnrnpa2b1 -7378
Pdcd4 -6988
Mtap -6818
Psme2 -6584
Lcp1 -5846
Capza1 -5795
Gsto1 -5545
Snrpa1 -5224
Cnn2 -5021
Pak2 -4999
Hnrnpf -4672
P4hb -4375
Taldo1 -3813
Sod2 -3755
Sod1 -3215
Cfl1 -3018
Aip -2618
Jak1 -2019
Pitpna -1698
Msn -1261
Arf1 -564
Il12a -358
Bola2 -8
Anxa2 509
Lmnb1 1473
Mif 4007
Jak2 4364
Il12rb1 5221
Tyk2 8074


PROCESSING OF SMDT1

PROCESSING OF SMDT1
742
set PROCESSING OF SMDT1
setSize 16
pANOVA 0.00291
s.dist -0.43
p.adjustANOVA 0.0202



Top enriched genes

Top 20 genes
GeneID Gene Rank
Maip1 -7981
Pmpcb -7895
Micu2 -7860
Micu3 -7016
Yme1l1 -7007
Phb -6580
Mcub -6561
Parl -6114
Smdt1 -4004
Stoml2 -3740
Micu1 -1008
Phb2 -100
Pmpca 348
Spg7 1923
Mcu 2786
Afg3l2 4406

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Maip1 -7981
Pmpcb -7895
Micu2 -7860
Micu3 -7016
Yme1l1 -7007
Phb -6580
Mcub -6561
Parl -6114
Smdt1 -4004
Stoml2 -3740
Micu1 -1008
Phb2 -100
Pmpca 348
Spg7 1923
Mcu 2786
Afg3l2 4406


GLYCOGEN SYNTHESIS

GLYCOGEN SYNTHESIS
388
set GLYCOGEN SYNTHESIS
setSize 14
pANOVA 0.0056
s.dist -0.428
p.adjustANOVA 0.0333



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ugp2 -8317
Ppp1r3c -8314
Gyg -6830
Rps27a -6495
Pgm2l1 -6098
Pgm2 -5623
Uba52 -3960
Epm2a -3490
Gbe1 -3313
Pgm1 -2590
Ubb -1705
Nhlrc1 143
Ubc 176
Gys1 7324

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ugp2 -8317
Ppp1r3c -8314
Gyg -6830
Rps27a -6495
Pgm2l1 -6098
Pgm2 -5623
Uba52 -3960
Epm2a -3490
Gbe1 -3313
Pgm1 -2590
Ubb -1705
Nhlrc1 143
Ubc 176
Gys1 7324


AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA

AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
85
set AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
setSize 54
pANOVA 7.14e-08
s.dist -0.424
p.adjustANOVA 2.2e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Hspa8 -7919
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Pabpc1 -7327
Hnrnpd -7317
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Psma6 -8083
Psma3 -8008
Psmc6 -7952
Hspa8 -7919
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Pabpc1 -7327
Hnrnpd -7317
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Psmd1 -7050
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Rps27a -6495
Psmd8 -6421
Psma7 -5400
Psmc5 -4628
Psmb4 -4130
Uba52 -3960
Psme3 -3372
Sem1 -3270
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Psmb6 -1711
Ubb -1705
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Ubc 176
Psmd9 182
Psmf1 393
Psmd11 661
Hspa1a 1010
Psmb2 1247
Psmd4 1519
Psmc4 2323
Psmb11 2711
Psme4 3582
Eif4g1 3969
Psmb5 4171
Hspb1 4930
Psmd3 7171


TRANSLATION

TRANSLATION
1122
set TRANSLATION
setSize 286
pANOVA 7.33e-35
s.dist -0.423
p.adjustANOVA 8.59e-32



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
N6amt1 -8311
Eif5b -8297
Rpl30 -8293
Spcs2 -8284
Eif4a2 -8274
Ppa1 -8273
Eif5 -8213
Eif3j2 -8206
Eif3e -8202
Eif4e -8156
Mrpl50 -8144
Rpl22l1 -8141
Mrps31 -8106
Eif2s1 -8079
Rplp0 -8066

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps18 -8356
Eef1e1 -8345
Rps7 -8344
Rpl35a -8326
Eif2s2 -8324
N6amt1 -8311
Eif5b -8297
Rpl30 -8293
Spcs2 -8284
Eif4a2 -8274
Ppa1 -8273
Eif5 -8213
Eif3j2 -8206
Eif3e -8202
Eif4e -8156
Mrpl50 -8144
Rpl22l1 -8141
Mrps31 -8106
Eif2s1 -8079
Rplp0 -8066
Mrps22 -8059
Rpl5 -8040
Eif3m -8002
Mrps30 -7993
Nars -7987
Srp54a -7879
Mrpl15 -7863
Mrps18c -7808
Rpl27a -7806
Rps2 -7768
Spcs3 -7739
Rars -7667
Eef1g -7647
Mrpl48 -7642
Rpl36a -7624
Srp19 -7606
Mrpl1 -7604
Rps24 -7591
Rpl29 -7590
Aimp1 -7569
Ptcd3 -7536
Rpl26 -7528
Mrps36 -7475
Dars -7464
Rpl3 -7423
Gars -7392
Mrpl13 -7390
Mrpl33 -7361
Pabpc1 -7327
Mrps23 -7315
Ssr3 -7313
Etf1 -7308
Rps3a1 -7247
Sars -7189
Mrpl19 -7180
Ssr1 -7167
Rpl15 -7145
Eif3h -7126
Mrpl32 -7120
Mrpl16 -7108
Rps4x -7101
Ppa2 -7040
Rpl6 -6987
Chchd1 -6871
Mrpl47 -6859
Eif2b3 -6845
Mrpl34 -6826
Eef1b2 -6800
Rps6 -6778
Rpl9 -6764
Sec61g -6747
Rpl24 -6731
Srp14 -6719
Eif1ax -6714
Mrps25 -6671
Eif2s3x -6648
Spcs1 -6626
Mrps5 -6624
Mrps35 -6621
Rps3 -6619
Rpl7 -6613
Rps8 -6582
Rpl13a -6546
Rpl17 -6544
Rps23 -6540
Rps27a -6495
Mrpl54 -6411
Sec11a -6393
Hars -6384
Mrpl39 -6377
Mrps10 -6372
Mrpl35 -6327
Rpl11 -6314
Rpl14 -6262
Mrpl42 -6237
Rpl4 -6223
Mtif3 -6198
Rpl22 -6168
Mrpl11 -6165
Rps14 -6141
Mrpl30 -6085
Srp9 -6063
Rps13 -6050
Eif3a -6011
Trmt112 -6003
Rps27l -5975
Mrps14 -5890
Eef1a1 -5772
Eif4b -5755
Rps25 -5718
Mrpl18 -5711
Mrps33 -5649
Mrps2 -5634
Rpl23a -5554
Rpl18a -5540
Mrpl40 -5479
Tsfm -5467
Rpl23 -5442
Rps9 -5358
Eif3g -5313
Mrpl17 -5226
Sec11c -5203
Rpl31 -5187
Rps16 -5184
Mrps7 -5182
Mtrf1l -5086
Rps20 -5080
Eprs -5045
Rpl21 -5011
Rpl27 -4994
Rpl36al -4919
Mrpl24 -4884
Mrpl3 -4810
Rpl10a -4803
Mrpl23 -4772
Mrpl10 -4753
Rps19 -4737
Mtif2 -4710
Mrpl43 -4558
Rpsa -4551
Mrps18b -4540
Aurkaip1 -4521
Rps11 -4519
Rpl7a -4362
Mrpl12 -4341
Rps10 -4314
Mrpl44 -4260
Mrps18a -4231
Eif4a1 -4206
Rpn1 -4191
Eif3j1 -4145
Dars2 -4141
Mrps9 -4127
Mrps16 -4124
Mrps28 -4082
Rars2 -4079
Uba52 -3960
Rpl28 -3949
Rps26 -3865
Rps17 -3848
Mrps6 -3721
Rpl19 -3712
Mrpl49 -3668
Rpl32 -3656
Rps27 -3639
Kars -3398
Rps15a -3370
Eif4ebp1 -3362
Mrpl51 -3295
Mrpl9 -3284
Fau -3267
Tram1 -3222
Yars2 -3212
Rpl37a -3095
Mars2 -3057
Yars -3043
Rps5 -3041
Fars2 -3040
Mrps17 -3013
Rpl34 -3010
Mrpl46 -2970
Rpl18 -2938
Sec61b -2933
Mrpl41 -2811
Rpl39 -2737
Srp72 -2721
Eif3c -2718
Ssr4 -2693
Rplp1 -2691
Mrpl27 -2636
Rpl8 -2622
Eif2b5 -2578
Mrps21 -2509
Mrpl22 -2443
Ssr2 -2440
Eif3k -2431
Eif3d -2344
Mrps24 -2317
Mrpl21 -2283
Rps15 -2201
Farsb -2005
Rpl13 -1947
Mrpl52 -1931
Mrpl28 -1883
Rpl35 -1857
Rps12 -1815
Eif3f -1745
Eef1d -1550
Gadd45gip1 -1433
Rps21 -1427
Gfm1 -1293
Mrrf -1288
Lars -1221
Mrpl36 -1190
Eef1a2 -1005
Eef2 -752
Mrps12 -732
Mrps15 -684
Mrpl14 -672
Mrpl55 -612
Aimp2 -461
Rplp2 -429
Mrpl20 -371
Mrps26 -247
Rpn2 -246
Rpl36 -165
Nars2 17
Srprb 131
Rpl37 145
Ddost 192
Tars 251
Mrpl53 258
Gspt2 283
Eif3i 284
Aars 355
Rpl10 514
Mrpl2 760
Mrpl57 904
Rpl12 951
Tufm 1249
Rpl38 1302
Pars2 1528
Eif4h 1596
Mtfmt 1692
Sec61a2 1781
Mrps11 1827
Mrps34 1876
Ears2 1928
Mrpl58 1955
Hars2 2071
Eif2b4 2120
Gspt1 2174
Eif3l 2389
Rps28 2422
Eif2b1 2549
Tars2 2665
Srpr 2709
Eif3b 3053
Mrpl38 3067
Iars2 3149
Dap3 3316
Apeh 3619
Lars2 3659
Gfm2 3691
Mrps27 3875
Eif4g1 3969
Rps29 4006
Wars2 4219
Wars 4475
Iars 5545
Mrpl37 5577
Cars 5765
Oxa1l 6029
Srp68 6072
Sars2 6259
Qars 6325
Farsa 6334
Vars 6427
Mars1 6721
Eif2b2 6854
Cars2 7047
Mrpl4 7211
Sec61a1 7338
Eral1 7587
Vars2 7733
Aars2 7882


MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION
570
set MITOCHONDRIAL TRANSLATION
setSize 93
pANOVA 1.81e-12
s.dist -0.423
p.adjustANOVA 1.11e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mrpl50 -8144
Mrps31 -8106
Mrps22 -8059
Mrps30 -7993
Mrpl15 -7863
Mrps18c -7808
Mrpl48 -7642
Mrpl1 -7604
Ptcd3 -7536
Mrps36 -7475
Mrpl13 -7390
Mrpl33 -7361
Mrps23 -7315
Mrpl19 -7180
Mrpl32 -7120
Mrpl16 -7108
Chchd1 -6871
Mrpl47 -6859
Mrpl34 -6826
Mrps25 -6671

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mrpl50 -8144
Mrps31 -8106
Mrps22 -8059
Mrps30 -7993
Mrpl15 -7863
Mrps18c -7808
Mrpl48 -7642
Mrpl1 -7604
Ptcd3 -7536
Mrps36 -7475
Mrpl13 -7390
Mrpl33 -7361
Mrps23 -7315
Mrpl19 -7180
Mrpl32 -7120
Mrpl16 -7108
Chchd1 -6871
Mrpl47 -6859
Mrpl34 -6826
Mrps25 -6671
Mrps5 -6624
Mrps35 -6621
Mrpl54 -6411
Mrpl39 -6377
Mrps10 -6372
Mrpl35 -6327
Mrpl42 -6237
Mtif3 -6198
Mrpl11 -6165
Mrpl30 -6085
Mrps14 -5890
Mrpl18 -5711
Mrps33 -5649
Mrps2 -5634
Mrpl40 -5479
Tsfm -5467
Mrpl17 -5226
Mrps7 -5182
Mtrf1l -5086
Mrpl24 -4884
Mrpl3 -4810
Mrpl23 -4772
Mrpl10 -4753
Mtif2 -4710
Mrpl43 -4558
Mrps18b -4540
Aurkaip1 -4521
Mrpl12 -4341
Mrpl44 -4260
Mrps18a -4231
Mrps9 -4127
Mrps16 -4124
Mrps28 -4082
Mrps6 -3721
Mrpl49 -3668
Mrpl51 -3295
Mrpl9 -3284
Mrps17 -3013
Mrpl46 -2970
Mrpl41 -2811
Mrpl27 -2636
Mrps21 -2509
Mrpl22 -2443
Mrps24 -2317
Mrpl21 -2283
Mrpl52 -1931
Mrpl28 -1883
Gadd45gip1 -1433
Gfm1 -1293
Mrrf -1288
Mrpl36 -1190
Mrps12 -732
Mrps15 -684
Mrpl14 -672
Mrpl55 -612
Mrpl20 -371
Mrps26 -247
Mrpl53 258
Mrpl2 760
Mrpl57 904
Tufm 1249
Mtfmt 1692
Mrps11 1827
Mrps34 1876
Mrpl58 1955
Mrpl38 3067
Dap3 3316
Gfm2 3691
Mrps27 3875
Mrpl37 5577
Oxa1l 6029
Mrpl4 7211
Eral1 7587


FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
327
set FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize 18
pANOVA 0.00191
s.dist -0.423
p.adjustANOVA 0.014



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp5pb -7848
Atp5c1 -7618
Dmac2l -7416
mt-Atp6 -7410
Atp5h -7400
Atp5b -6701
Atp5a1 -6246
Atp5j -6240
Atp5l -5922
Atp5g3 -5787
Atp5o -4857
Atp5j2 -3789
Atp5e -3319
mt-Atp8 -20
Atp5d 1601
Atp5g1 4677
Atp5k 5443
Atp5g2 6507

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp5pb -7848
Atp5c1 -7618
Dmac2l -7416
mt-Atp6 -7410
Atp5h -7400
Atp5b -6701
Atp5a1 -6246
Atp5j -6240
Atp5l -5922
Atp5g3 -5787
Atp5o -4857
Atp5j2 -3789
Atp5e -3319
mt-Atp8 -20
Atp5d 1601
Atp5g1 4677
Atp5k 5443
Atp5g2 6507


METABOLISM OF POLYAMINES

METABOLISM OF POLYAMINES
551
set METABOLISM OF POLYAMINES
setSize 58
pANOVA 3.07e-08
s.dist -0.42
p.adjustANOVA 1.06e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Amd1 -8099
Psma6 -8083
Sat1 -8037
Psma3 -8008
Psmc6 -7952
Sms -7780
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Oaz3 -7086
Psmd1 -7050
Oaz2 -6911
Psmc2 -6811

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psmc1 -8281
Psmd12 -8214
Amd1 -8099
Psma6 -8083
Sat1 -8037
Psma3 -8008
Psmc6 -7952
Sms -7780
Psmb1 -7592
Psmd14 -7555
Psmd6 -7433
Psma2 -7377
Psmb7 -7343
Psmd10 -7234
Psma4 -7157
Psma5 -7119
Oaz3 -7086
Psmd1 -7050
Oaz2 -6911
Psmc2 -6811
Psmb8 -6795
Psma1 -6696
Psmd7 -6678
Psme2 -6584
Psmd8 -6421
Nqo1 -5963
Psma7 -5400
Psmc5 -4628
Azin1 -4611
Psmb4 -4130
Oaz1 -4001
Odc1 -3909
Paox -3581
Psme3 -3372
Sem1 -3270
Psmd5 -3241
Psme1 -3149
Psmc3 -3144
Psmb9 -3039
Psmb10 -2592
Psmb6 -1711
Psmd13 -1434
Psmb3 -868
Psmd2 -105
Psmd9 182
Psmf1 393
Psmd11 661
Psmb2 1247
Psmd4 1519
Agmat 1990
Psmc4 2323
Psmb11 2711
Psme4 3582
Psmb5 4171
Azin2 5123
Psmd3 7171
Srm 7557
Smox 8548


SYNAPTIC ADHESION LIKE MOLECULES

SYNAPTIC ADHESION LIKE MOLECULES
1028
set SYNAPTIC ADHESION LIKE MOLECULES
setSize 21
pANOVA 0.000884
s.dist 0.419
p.adjustANOVA 0.0075



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptprs 8535
Grin2c 8250
Grin1 8150
Ptprf 7633
Lrfn2 7441
Grin2d 7182
Grin2a 7145
Grin2b 6025
Lrfn1 5728
Gria1 5625
Lrfn4 5582
Dlg4 4881
Flot2 4865
Lrfn3 4373
Dlg3 2731
Flot1 2121
Ptprd 795
Gria3 -1082
Dlg1 -6018
Gria4 -6217

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptprs 8535
Grin2c 8250
Grin1 8150
Ptprf 7633
Lrfn2 7441
Grin2d 7182
Grin2a 7145
Grin2b 6025
Lrfn1 5728
Gria1 5625
Lrfn4 5582
Dlg4 4881
Flot2 4865
Lrfn3 4373
Dlg3 2731
Flot1 2121
Ptprd 795
Gria3 -1082
Dlg1 -6018
Gria4 -6217
Rtn3 -6949


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
180
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 0.000251
s.dist -0.415
p.adjustANOVA 0.00244



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cct6a -8302
Tcp1 -8258
Vbp1 -8131
Cct2 -8114
Pfdn4 -8042
Cct4 -7975
Cct8 -7759
Pfdn1 -6376
Cct3 -6259
Cct7 -5893
Pfdn2 -5607
Pfdn5 -4226
Cct5 -4077
Pfdn6 -3885
Tuba4a -3429
Tuba1b -3400
Tuba1a -3146
Tuba8 -1901
Tubb6 -1519
Actb -1167

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a -8302
Tcp1 -8258
Vbp1 -8131
Cct2 -8114
Pfdn4 -8042
Cct4 -7975
Cct8 -7759
Pfdn1 -6376
Cct3 -6259
Cct7 -5893
Pfdn2 -5607
Pfdn5 -4226
Cct5 -4077
Pfdn6 -3885
Tuba4a -3429
Tuba1b -3400
Tuba1a -3146
Tuba8 -1901
Tubb6 -1519
Actb -1167
Tubb4b -822
Tubb3 440
Tubb2b 1631
Tubb2a 4725
Tubb4a 4793
Tuba1c 8404


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
146
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 10
pANOVA 0.0237
s.dist -0.413
p.adjustANOVA 0.104



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ywhaq -8300
Ywhab -8049
Ywhae -7948
Ywhah -6972
Ywhaz -6204
Chek2 -5935
Chek1 -3066
Wee1 952
Ywhag 4934
Sfn 6755

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ywhaq -8300
Ywhab -8049
Ywhae -7948
Ywhah -6972
Ywhaz -6204
Chek2 -5935
Chek1 -3066
Wee1 952
Ywhag 4934
Sfn 6755


G BETA GAMMA SIGNALLING THROUGH CDC42

G BETA GAMMA SIGNALLING THROUGH CDC42
351
set G BETA GAMMA SIGNALLING THROUGH CDC42
setSize 18
pANOVA 0.00246
s.dist -0.412
p.adjustANOVA 0.0175



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng11 -8252
Cdc42 -8238
Pak1 -8116
Gng10 -7220
Gng12 -7193
Gnb4 -5408
Gngt2 -5362
Gnb1 -5114
Gng5 -4383
Gng2 -4118
Gng3 -4032
Gng4 -2468
Gng13 -2173
Gnb5 -453
Gng8 917
Gnb2 2170
Gng7 2566
Arhgef6 6116

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng11 -8252
Cdc42 -8238
Pak1 -8116
Gng10 -7220
Gng12 -7193
Gnb4 -5408
Gngt2 -5362
Gnb1 -5114
Gng5 -4383
Gng2 -4118
Gng3 -4032
Gng4 -2468
Gng13 -2173
Gnb5 -453
Gng8 917
Gnb2 2170
Gng7 2566
Arhgef6 6116


ACTIVATION OF SMO

ACTIVATION OF SMO
26
set ACTIVATION OF SMO
setSize 16
pANOVA 0.00472
s.dist 0.408
p.adjustANOVA 0.0296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Arrb2 8039
Evc2 7665
Smo 7653
Boc 6967
Iqce 6685
Cdon 6010
Gas8 5833
Arrb1 5258
Evc 5254
Grk2 5048
Ptch1 4944
Gas1 1456
Kif3a -2304
Csnk1a1 -2327
Shh -3498
Efcab7 -5660

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Arrb2 8039
Evc2 7665
Smo 7653
Boc 6967
Iqce 6685
Cdon 6010
Gas8 5833
Arrb1 5258
Evc 5254
Grk2 5048
Ptch1 4944
Gas1 1456
Kif3a -2304
Csnk1a1 -2327
Shh -3498
Efcab7 -5660


THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
1063
set THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
setSize 172
pANOVA 2.88e-20
s.dist -0.408
p.adjustANOVA 5.63e-18



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cycs -8327
Slc16a1 -8316
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
mt-Co1 -8117
Dld -8103
Ndufaf2 -8036
Uqcrc2 -7974
Atp5pb -7848
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
Fh1 -7716
mt-Nd2 -7691
Ndufa10 -7690
Ucp3 -7686
Cox20 -7655
Glo1 -7630
Atp5c1 -7618

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8327
Slc16a1 -8316
Ndufv2 -8225
mt-Nd3 -8217
Ndufc2 -8184
mt-Co1 -8117
Dld -8103
Ndufaf2 -8036
Uqcrc2 -7974
Atp5pb -7848
Ndufaf4 -7811
Ndufs4 -7781
mt-Nd1 -7775
Fh1 -7716
mt-Nd2 -7691
Ndufa10 -7690
Ucp3 -7686
Cox20 -7655
Glo1 -7630
Atp5c1 -7618
Ndufb4 -7616
Ndufaf1 -7515
Mpc2 -7458
Sucla2 -7429
Dmac2l -7416
mt-Atp6 -7410
Pdha1 -7404
Atp5h -7400
Cox7a2l -7370
Pdhb -7363
Etfa -7356
mt-Nd4 -7348
Vdac1 -7307
mt-Co2 -7285
mt-Cytb -7188
Ndufaf5 -7171
Sco1 -7112
Idh3a -7067
Ndufb5 -7049
Suclg2 -7048
mt-Nd6 -7046
mt-Co3 -7028
Slc25a14 -7019
Me1 -6992
Cox7b -6990
Mpc1 -6940
Pdp1 -6808
Ndufb6 -6773
Ndufa4 -6744
Coq10b -6737
mt-Nd5 -6712
Atp5b -6701
Ndufc1 -6489
Nubpl -6400
Bsg -6399
Ndufa8 -6288
Ndufa9 -6258
Atp5a1 -6246
Atp5j -6240
Fahd1 -6232
Cox16 -6207
Uqcrb -6105
Ndufs2 -6093
Ndufb3 -6047
Atp5l -5922
Sdhc -5905
Ndufb9 -5882
Ndufa12 -5878
Atp5g3 -5787
Ndufa5 -5746
Cox6c -5703
Adhfe1 -5510
Pdhx -5464
Suclg1 -5405
Pdk3 -5398
Etfb -5388
Ldha -5319
Ndufs5 -5271
Ndufb2 -5052
Ndufs6 -5003
Sdhd -4864
Ndufs1 -4858
Atp5o -4857
Etfdh -4829
Ldhb -4796
Ndufb11 -4703
Me2 -4666
Ndufb8 -4574
L2hgdh -4572
Surf1 -4552
Tmem126b -4549
Dlat -4457
Uqcrh -4432
Ndufaf6 -4409
Cox5a -4305
Cox7c -4253
Sdha -4022
Pdp2 -3998
Cox4i1 -3971
Ndufa6 -3969
Atp5j2 -3789
Ndufs8 -3711
Ndufs3 -3557
Sdhb -3435
Atp5e -3319
Sco2 -3311
Uqcrq -2949
Pdk4 -2902
Ndufaf7 -2652
Cs -2586
Ndufv1 -2446
Cox14 -2445
Ndufa1 -2342
Pm20d1 -1959
Gstz1 -1919
Ndufb1 -1848
Cox19 -1734
Timmdc1 -1652
Ndufab1 -1622
Cox6b1 -1294
Lrpprc -1274
Cox6a1 -1024
Ndufaf3 -1006
Ndufa7 -922
Uqcrfs1 -898
Aco2 -835
Slc16a3 -829
Nnt -698
Ndufb7 -677
Uqcr10 -620
Hagh -385
Idh3b -364
Ndufa13 -112
mt-Atp8 -20
Ndufb10 93
Ndufa2 115
Mdh2 162
Cox5b 523
Coq10a 573
Cox8a 688
Ndufa11 761
Cyc1 765
Me3 941
Uqcr11 1036
Cox11 1132
Ndufv3 1316
Acad9 1432
Atp5d 1601
Uqcrc1 1965
Pdk2 2092
Ogdh 2420
Dlst 2717
Ndufs7 2959
Ndufa3 3432
Pdk1 3939
Pdpr 4069
Idh3g 4362
Atp5g1 4677
Atp5k 5443
Ecsit 5455
Tmem186 5506
Rxra 5911
Cox18 6026
Taco1 6075
D2hgdh 6188
Slc16a8 6235
Atp5g2 6507
Trap1 6575
Idh2 6751
Slc25a27 7257
Ucp2 7420
Ppard 8045


CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS
191
set CROSSLINKING OF COLLAGEN FIBRILS
setSize 15
pANOVA 0.00647
s.dist 0.406
p.adjustANOVA 0.0368



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pxdn 8424
Col4a3 7549
Loxl3 7501
Col4a2 6279
Col4a1 5895
Col4a5 5231
Bmp1 4599
Col4a4 4592
Loxl1 4222
Tll2 2651
Col1a1 1861
Pcolce 67
Loxl2 -1046
Tll1 -1920
Col1a2 -2692

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pxdn 8424
Col4a3 7549
Loxl3 7501
Col4a2 6279
Col4a1 5895
Col4a5 5231
Bmp1 4599
Col4a4 4592
Loxl1 4222
Tll2 2651
Col1a1 1861
Pcolce 67
Loxl2 -1046
Tll1 -1920
Col1a2 -2692


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report