date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik 0.0259293 0.4565576
0610009E02Rik 0.7519591 -0.4069908
0610009L18Rik -1.0644467 -0.1869110
0610010K14Rik 0.4476085 -0.3711485
0610012G03Rik -0.1633199 -0.3421633
0610030E20Rik -0.6249661 0.0842539

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 17476
duplicated_genes_present 0
num_profile_genes_in_sets 8392
num_profile_genes_not_in_sets 9084
profile_pearson_correl 0.66898
profile_spearman_correl 0.65189

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 427
num_genesets_included 1177

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 290

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 9.58e-04 8.23e-03 0.784 0.6080 0.4940 2.65e-04 3.03e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.43e-07 9.85e-06 0.776 0.7070 0.3200 9.37e-08 1.56e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 2.27e-03 1.50e-02 0.741 0.5590 0.4860 7.92e-04 3.59e-03
RHOBTB3 ATPASE CYCLE 10 7.24e-03 3.34e-02 0.729 0.5530 0.4750 2.45e-03 9.33e-03
CITRIC ACID CYCLE TCA CYCLE 22 2.54e-05 4.81e-04 0.728 0.5190 0.5110 2.50e-05 3.39e-05
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.82e-05 5.27e-04 0.700 0.5340 0.4520 9.32e-06 1.73e-04
OLFACTORY SIGNALING PATHWAY 37 1.32e-07 5.97e-06 0.686 -0.4720 -0.4980 6.88e-07 1.55e-07
CALNEXIN CALRETICULIN CYCLE 26 3.26e-05 5.90e-04 0.661 0.4550 0.4790 5.90e-05 2.32e-05
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 2.16e-03 1.46e-02 0.646 0.5750 0.2950 5.68e-04 7.70e-02
NUCLEOBASE BIOSYNTHESIS 15 2.74e-03 1.72e-02 0.636 0.5070 0.3840 6.70e-04 9.94e-03
RETROGRADE NEUROTROPHIN SIGNALLING 13 1.03e-02 4.43e-02 0.622 0.4520 0.4270 4.77e-03 7.74e-03
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.30e-05 2.89e-04 0.595 0.4200 0.4220 1.74e-05 1.53e-05
BRANCHED CHAIN AMINO ACID CATABOLISM 21 8.17e-04 7.40e-03 0.592 0.3590 0.4700 4.42e-03 1.91e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.29e-04 6.86e-03 0.590 0.3490 0.4760 5.66e-03 1.57e-04
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 2.07e-03 1.42e-02 0.582 0.3970 0.4260 2.11e-03 9.74e-04
LDL CLEARANCE 16 7.82e-03 3.51e-02 0.570 0.4370 0.3650 2.47e-03 1.15e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 8.88e-08 4.54e-06 0.567 0.4930 0.2800 1.48e-08 1.31e-03
GLYCOSPHINGOLIPID METABOLISM 38 1.57e-05 3.24e-04 0.566 0.4070 0.3940 1.44e-05 2.58e-05
RECEPTOR MEDIATED MITOPHAGY 11 4.28e-02 1.26e-01 0.554 0.4240 0.3570 1.49e-02 4.03e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 6.23e-02 1.61e-01 0.548 0.4140 0.3590 2.35e-02 4.91e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 4.39e-02 1.29e-01 0.548 0.3020 0.4570 9.79e-02 1.24e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.65e-04 3.24e-03 0.539 0.5350 0.0688 8.36e-04 6.68e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 3.82e-02 1.17e-01 0.537 0.4170 0.3390 1.24e-02 4.20e-02
KERATAN SULFATE BIOSYNTHESIS 24 5.54e-05 9.32e-04 0.536 0.4960 0.2010 2.55e-05 8.80e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 1.51e-02 5.76e-02 0.533 0.2670 0.4620 9.62e-02 3.95e-03
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 7.41e-04 6.92e-03 0.529 0.3270 0.4160 3.27e-03 1.85e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 4.71e-03 2.46e-02 0.525 0.3970 0.3430 1.62e-03 6.46e-03
GLYCOGEN SYNTHESIS 14 1.42e-02 5.55e-02 0.522 0.4490 0.2660 3.63e-03 8.49e-02
GLYCOGEN STORAGE DISEASES 12 2.09e-02 7.39e-02 0.507 0.4540 0.2250 6.45e-03 1.77e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.08e-05 2.51e-04 0.506 0.3700 0.3450 7.34e-06 2.87e-05
INSULIN PROCESSING 24 3.92e-03 2.18e-02 0.504 0.3470 0.3660 3.26e-03 1.94e-03
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.17e-03 1.46e-02 0.502 0.0586 0.4980 7.36e-01 4.20e-03
GLYCOGEN METABOLISM 25 1.68e-03 1.26e-02 0.499 0.4130 0.2800 3.54e-04 1.52e-02
FATTY ACYL COA BIOSYNTHESIS 32 7.26e-04 6.86e-03 0.498 0.3430 0.3620 7.81e-04 4.00e-04
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.99e-05 3.98e-04 0.498 0.4770 0.1420 2.52e-05 2.12e-01
KERATAN SULFATE KERATIN METABOLISM 30 3.75e-05 6.68e-04 0.498 0.4570 0.1970 1.46e-05 6.20e-02
SPHINGOLIPID METABOLISM 80 6.31e-09 4.13e-07 0.495 0.3010 0.3930 3.32e-06 1.22e-09
CD28 DEPENDENT VAV1 PATHWAY 11 5.59e-02 1.50e-01 0.490 0.4180 0.2570 1.64e-02 1.40e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 1.14e-05 2.58e-04 0.489 0.3840 0.3040 2.69e-06 2.05e-04
CTLA4 INHIBITORY SIGNALING 20 1.16e-02 4.80e-02 0.487 0.3100 0.3760 1.65e-02 3.59e-03
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 2.79e-02 9.24e-02 0.487 0.2810 0.3980 5.98e-02 7.60e-03
SCAVENGING OF HEME FROM PLASMA 11 4.81e-02 1.35e-01 0.485 -0.2340 -0.4250 1.79e-01 1.46e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.43e-02 1.09e-01 0.482 0.4150 0.2460 9.62e-03 1.25e-01
MET ACTIVATES RAP1 AND RAC1 10 2.86e-02 9.42e-02 0.480 0.1590 0.4530 3.83e-01 1.32e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.26e-03 2.30e-02 0.479 0.4070 0.2540 9.60e-04 3.92e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.90e-02 1.55e-01 0.479 0.3000 0.3740 6.11e-02 1.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 6.15e-02 1.60e-01 0.478 0.3930 0.2710 1.83e-02 1.04e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.90e-05 5.33e-04 0.475 0.3280 0.3440 5.12e-05 2.16e-05
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 5.18e-10 5.08e-08 0.473 0.4650 0.0873 2.45e-08 2.95e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 1.41e-03 1.13e-02 0.473 0.2380 0.4090 3.57e-02 3.08e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 9.58e-04 8.23e-03 0.78400 6.08e-01 0.494000 2.65e-04 3.03e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.43e-07 9.85e-06 0.77600 7.07e-01 0.320000 9.37e-08 1.56e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 2.27e-03 1.50e-02 0.74100 5.59e-01 0.486000 7.92e-04 3.59e-03
RHOBTB3 ATPASE CYCLE 10 7.24e-03 3.34e-02 0.72900 5.53e-01 0.475000 2.45e-03 9.33e-03
CITRIC ACID CYCLE TCA CYCLE 22 2.54e-05 4.81e-04 0.72800 5.19e-01 0.511000 2.50e-05 3.39e-05
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 2.82e-05 5.27e-04 0.70000 5.34e-01 0.452000 9.32e-06 1.73e-04
OLFACTORY SIGNALING PATHWAY 37 1.32e-07 5.97e-06 0.68600 -4.72e-01 -0.498000 6.88e-07 1.55e-07
CALNEXIN CALRETICULIN CYCLE 26 3.26e-05 5.90e-04 0.66100 4.55e-01 0.479000 5.90e-05 2.32e-05
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 2.16e-03 1.46e-02 0.64600 5.75e-01 0.295000 5.68e-04 7.70e-02
NUCLEOBASE BIOSYNTHESIS 15 2.74e-03 1.72e-02 0.63600 5.07e-01 0.384000 6.70e-04 9.94e-03
RETROGRADE NEUROTROPHIN SIGNALLING 13 1.03e-02 4.43e-02 0.62200 4.52e-01 0.427000 4.77e-03 7.74e-03
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.30e-05 2.89e-04 0.59500 4.20e-01 0.422000 1.74e-05 1.53e-05
BRANCHED CHAIN AMINO ACID CATABOLISM 21 8.17e-04 7.40e-03 0.59200 3.59e-01 0.470000 4.42e-03 1.91e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.29e-04 6.86e-03 0.59000 3.49e-01 0.476000 5.66e-03 1.57e-04
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 2.07e-03 1.42e-02 0.58200 3.97e-01 0.426000 2.11e-03 9.74e-04
LDL CLEARANCE 16 7.82e-03 3.51e-02 0.57000 4.37e-01 0.365000 2.47e-03 1.15e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 8.88e-08 4.54e-06 0.56700 4.93e-01 0.280000 1.48e-08 1.31e-03
GLYCOSPHINGOLIPID METABOLISM 38 1.57e-05 3.24e-04 0.56600 4.07e-01 0.394000 1.44e-05 2.58e-05
RECEPTOR MEDIATED MITOPHAGY 11 4.28e-02 1.26e-01 0.55400 4.24e-01 0.357000 1.49e-02 4.03e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 6.23e-02 1.61e-01 0.54800 4.14e-01 0.359000 2.35e-02 4.91e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 4.39e-02 1.29e-01 0.54800 3.02e-01 0.457000 9.79e-02 1.24e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.65e-04 3.24e-03 0.53900 5.35e-01 0.068800 8.36e-04 6.68e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 3.82e-02 1.17e-01 0.53700 4.17e-01 0.339000 1.24e-02 4.20e-02
KERATAN SULFATE BIOSYNTHESIS 24 5.54e-05 9.32e-04 0.53600 4.96e-01 0.201000 2.55e-05 8.80e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 1.51e-02 5.76e-02 0.53300 2.67e-01 0.462000 9.62e-02 3.95e-03
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 7.41e-04 6.92e-03 0.52900 3.27e-01 0.416000 3.27e-03 1.85e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 4.71e-03 2.46e-02 0.52500 3.97e-01 0.343000 1.62e-03 6.46e-03
GLYCOGEN SYNTHESIS 14 1.42e-02 5.55e-02 0.52200 4.49e-01 0.266000 3.63e-03 8.49e-02
GLYCOGEN STORAGE DISEASES 12 2.09e-02 7.39e-02 0.50700 4.54e-01 0.225000 6.45e-03 1.77e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 1.08e-05 2.51e-04 0.50600 3.70e-01 0.345000 7.34e-06 2.87e-05
INSULIN PROCESSING 24 3.92e-03 2.18e-02 0.50400 3.47e-01 0.366000 3.26e-03 1.94e-03
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.17e-03 1.46e-02 0.50200 5.86e-02 0.498000 7.36e-01 4.20e-03
GLYCOGEN METABOLISM 25 1.68e-03 1.26e-02 0.49900 4.13e-01 0.280000 3.54e-04 1.52e-02
FATTY ACYL COA BIOSYNTHESIS 32 7.26e-04 6.86e-03 0.49800 3.43e-01 0.362000 7.81e-04 4.00e-04
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.99e-05 3.98e-04 0.49800 4.77e-01 0.142000 2.52e-05 2.12e-01
KERATAN SULFATE KERATIN METABOLISM 30 3.75e-05 6.68e-04 0.49800 4.57e-01 0.197000 1.46e-05 6.20e-02
SPHINGOLIPID METABOLISM 80 6.31e-09 4.13e-07 0.49500 3.01e-01 0.393000 3.32e-06 1.22e-09
CD28 DEPENDENT VAV1 PATHWAY 11 5.59e-02 1.50e-01 0.49000 4.18e-01 0.257000 1.64e-02 1.40e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 1.14e-05 2.58e-04 0.48900 3.84e-01 0.304000 2.69e-06 2.05e-04
CTLA4 INHIBITORY SIGNALING 20 1.16e-02 4.80e-02 0.48700 3.10e-01 0.376000 1.65e-02 3.59e-03
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 2.79e-02 9.24e-02 0.48700 2.81e-01 0.398000 5.98e-02 7.60e-03
SCAVENGING OF HEME FROM PLASMA 11 4.81e-02 1.35e-01 0.48500 -2.34e-01 -0.425000 1.79e-01 1.46e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 3.43e-02 1.09e-01 0.48200 4.15e-01 0.246000 9.62e-03 1.25e-01
MET ACTIVATES RAP1 AND RAC1 10 2.86e-02 9.42e-02 0.48000 1.59e-01 0.453000 3.83e-01 1.32e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.26e-03 2.30e-02 0.47900 4.07e-01 0.254000 9.60e-04 3.92e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.90e-02 1.55e-01 0.47900 3.00e-01 0.374000 6.11e-02 1.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 6.15e-02 1.60e-01 0.47800 3.93e-01 0.271000 1.83e-02 1.04e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.90e-05 5.33e-04 0.47500 3.28e-01 0.344000 5.12e-05 2.16e-05
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 5.18e-10 5.08e-08 0.47300 4.65e-01 0.087300 2.45e-08 2.95e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 1.41e-03 1.13e-02 0.47300 2.38e-01 0.409000 3.57e-02 3.08e-04
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.42e-04 1.91e-03 0.47000 1.42e-02 0.470000 9.22e-01 1.14e-03
CYTOSOLIC TRNA AMINOACYLATION 24 2.35e-03 1.53e-02 0.46900 4.08e-01 0.232000 5.42e-04 4.88e-02
PURINE SALVAGE 12 3.40e-02 1.08e-01 0.46600 4.22e-01 0.198000 1.14e-02 2.34e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.85e-04 4.27e-03 0.46300 4.39e-01 0.144000 2.64e-04 2.31e-01
HYALURONAN UPTAKE AND DEGRADATION 11 1.20e-01 2.59e-01 0.46000 3.36e-01 0.314000 5.34e-02 7.17e-02
RAP1 SIGNALLING 15 5.50e-02 1.49e-01 0.46000 3.10e-01 0.340000 3.79e-02 2.26e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 3.81e-02 1.17e-01 0.45800 3.94e-01 0.235000 1.08e-02 1.28e-01
GAP JUNCTION ASSEMBLY 21 6.03e-05 9.72e-04 0.45700 4.54e-01 0.053500 3.14e-04 6.71e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 8.54e-02 2.04e-01 0.45700 3.21e-01 0.325000 4.53e-02 4.24e-02
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 7.84e-02 1.92e-01 0.45600 -2.33e-01 -0.392000 1.81e-01 2.44e-02
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.10e-02 1.96e-01 0.45600 2.94e-01 0.348000 6.65e-02 2.98e-02
ENDOSOMAL VACUOLAR PATHWAY 10 2.26e-03 1.50e-02 0.45500 -4.53e-01 0.045300 1.32e-02 8.04e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.43e-02 5.55e-02 0.45200 2.21e-01 0.394000 1.05e-01 3.80e-03
PEROXISOMAL LIPID METABOLISM 27 6.81e-03 3.17e-02 0.45100 3.13e-01 0.325000 4.92e-03 3.45e-03
RESPONSE OF MTB TO PHAGOCYTOSIS 21 1.33e-02 5.32e-02 0.44800 3.70e-01 0.252000 3.31e-03 4.53e-02
FERTILIZATION 13 4.20e-02 1.25e-01 0.44700 -2.06e-01 -0.397000 1.99e-01 1.32e-02
RHO GTPASES ACTIVATE IQGAPS 23 3.97e-04 4.29e-03 0.44400 4.28e-01 0.120000 3.81e-04 3.20e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 4.50e-09 3.12e-07 0.44400 3.76e-01 0.236000 5.76e-10 9.92e-05
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.34e-01 2.79e-01 0.44200 3.66e-01 0.248000 4.51e-02 1.74e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 9.64e-02 2.21e-01 0.44200 2.91e-01 0.332000 6.91e-02 3.81e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 5.31e-05 9.05e-04 0.44000 2.04e-01 0.390000 2.24e-02 1.22e-05
RAF ACTIVATION 34 2.66e-03 1.67e-02 0.43900 3.11e-01 0.309000 1.69e-03 1.81e-03
VLDLR INTERNALISATION AND DEGRADATION 12 1.05e-01 2.34e-01 0.43800 3.52e-01 0.262000 3.49e-02 1.16e-01
PROLONGED ERK ACTIVATION EVENTS 13 4.67e-02 1.34e-01 0.43800 1.99e-01 0.390000 2.13e-01 1.49e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 3.97e-03 2.18e-02 0.43700 4.36e-01 -0.036400 1.70e-02 8.42e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 1.79e-02 6.62e-02 0.43300 4.08e-01 0.146000 8.18e-03 3.44e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 1.36e-05 2.92e-04 0.43200 3.34e-01 0.274000 3.78e-06 1.54e-04
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 5.68e-02 1.51e-01 0.43200 1.44e-01 0.407000 4.31e-01 2.58e-02
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 5.68e-02 1.51e-01 0.43200 1.44e-01 0.407000 4.31e-01 2.58e-02
PLATELET SENSITIZATION BY LDL 15 4.73e-02 1.34e-01 0.43000 2.23e-01 0.368000 1.34e-01 1.37e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 6.40e-03 3.05e-02 0.43000 -1.55e-02 0.430000 9.32e-01 1.86e-02
KILLING MECHANISMS 11 1.27e-01 2.71e-01 0.42800 -3.53e-01 -0.241000 4.25e-02 1.67e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 1.16e-02 4.80e-02 0.42600 2.92e-01 0.310000 8.69e-03 5.28e-03
RECYCLING PATHWAY OF L1 40 1.39e-04 1.88e-03 0.42500 3.79e-01 0.194000 3.41e-05 3.39e-02
EPHRIN SIGNALING 19 4.42e-02 1.29e-01 0.42500 2.99e-01 0.303000 2.41e-02 2.24e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 1.93e-02 6.92e-02 0.42500 4.18e-01 0.079000 1.65e-02 6.50e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 8.41e-02 2.02e-01 0.42500 -3.14e-01 -0.285000 3.50e-02 5.57e-02
CS DS DEGRADATION 14 3.54e-02 1.12e-01 0.42400 3.86e-01 0.175000 1.24e-02 2.56e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 7.60e-02 1.89e-01 0.42100 -3.05e-01 -0.290000 3.48e-02 4.45e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 1.50e-01 2.99e-01 0.42000 3.56e-01 0.224000 5.14e-02 2.20e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 4.72e-02 1.34e-01 0.42000 2.56e-01 0.332000 5.97e-02 1.47e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 53 1.77e-04 2.29e-03 0.41900 -2.70e-01 -0.320000 6.80e-04 5.56e-05
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 9.91e-03 4.27e-02 0.41700 3.57e-01 0.216000 2.43e-03 6.75e-02
N GLYCAN ANTENNAE ELONGATION 15 1.42e-03 1.13e-02 0.41700 4.17e-01 0.011100 5.20e-03 9.41e-01
SPRY REGULATION OF FGF SIGNALING 16 7.41e-02 1.86e-01 0.41600 3.22e-01 0.264000 2.60e-02 6.76e-02
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.62e-02 2.05e-01 0.41600 2.62e-01 0.323000 7.92e-02 3.02e-02
DERMATAN SULFATE BIOSYNTHESIS 11 1.57e-01 3.07e-01 0.41600 3.32e-01 0.250000 5.65e-02 1.51e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 7.56e-03 3.44e-02 0.41400 3.33e-01 0.247000 1.90e-03 2.15e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 5.65e-02 1.51e-01 0.41300 2.09e-01 0.356000 1.60e-01 1.69e-02
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 1.15e-03 9.58e-03 0.41300 3.45e-01 0.227000 2.34e-04 1.55e-02
COHESIN LOADING ONTO CHROMATIN 10 1.69e-03 1.26e-02 0.41100 -1.53e-01 0.381000 4.01e-01 3.71e-02
INTRA GOLGI TRAFFIC 43 3.03e-04 3.54e-03 0.40900 2.06e-01 0.353000 1.95e-02 6.11e-05
GOLGI TO ER RETROGRADE TRANSPORT 119 4.79e-10 5.08e-08 0.40800 3.47e-01 0.214000 5.98e-11 5.46e-05
CARNITINE METABOLISM 14 1.63e-03 1.24e-02 0.40800 -1.76e-02 0.408000 9.09e-01 8.27e-03
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 1.87e-02 6.79e-02 0.40700 3.32e-01 0.237000 4.93e-03 4.47e-02
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 8.42e-02 2.02e-01 0.40200 3.71e-01 0.156000 3.33e-02 3.70e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 1.16e-02 4.80e-02 0.40200 3.02e-01 0.266000 4.25e-03 1.18e-02
ACYL CHAIN REMODELLING OF PG 10 1.67e-01 3.19e-01 0.40200 2.06e-01 0.345000 2.59e-01 5.92e-02
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 1.51e-01 3.00e-01 0.39800 2.65e-01 0.297000 9.80e-02 6.40e-02
RHOF GTPASE CYCLE 41 3.97e-04 4.29e-03 0.39800 1.85e-01 0.352000 4.09e-02 9.53e-05
ERKS ARE INACTIVATED 13 1.50e-01 2.99e-01 0.39700 2.59e-01 0.301000 1.06e-01 6.03e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 2.32e-01 4.01e-01 0.39400 -3.05e-01 -0.249000 9.46e-02 1.72e-01
LYSOSOME VESICLE BIOGENESIS 33 6.37e-03 3.05e-02 0.39200 3.19e-01 0.228000 1.53e-03 2.36e-02
O LINKED GLYCOSYLATION OF MUCINS 40 3.18e-03 1.89e-02 0.39100 2.48e-01 0.303000 6.63e-03 9.28e-04
KERATAN SULFATE DEGRADATION 11 4.24e-02 1.26e-01 0.39100 3.82e-01 0.086100 2.84e-02 6.21e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 4.57e-12 8.96e-10 0.39100 3.20e-01 0.226000 5.66e-13 3.66e-07
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 10 1.68e-01 3.21e-01 0.39100 -1.90e-01 -0.342000 2.99e-01 6.11e-02
CA DEPENDENT EVENTS 36 1.95e-03 1.37e-02 0.39000 1.94e-01 0.338000 4.38e-02 4.41e-04
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 3.93e-03 2.18e-02 0.39000 3.79e-01 0.092900 3.35e-03 4.72e-01
RHOV GTPASE CYCLE 33 3.57e-04 4.04e-03 0.39000 1.24e-01 0.370000 2.19e-01 2.37e-04
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 9.08e-02 2.13e-01 0.38600 2.06e-01 0.327000 1.67e-01 2.85e-02
NCAM1 INTERACTIONS 42 1.09e-03 9.16e-03 0.38400 -1.99e-01 -0.329000 2.58e-02 2.27e-04
TRNA AMINOACYLATION 42 2.38e-03 1.53e-02 0.38400 3.08e-01 0.230000 5.63e-04 1.00e-02
ER TO GOLGI ANTEROGRADE TRANSPORT 142 9.44e-10 7.72e-08 0.38100 3.13e-01 0.217000 1.22e-10 8.15e-06
GLUCONEOGENESIS 27 8.54e-03 3.79e-02 0.38000 3.38e-01 0.174000 2.38e-03 1.17e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 6.64e-04 6.41e-03 0.38000 3.78e-01 -0.041800 6.99e-03 7.65e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 5.96e-02 1.57e-01 0.37800 2.39e-01 0.293000 5.79e-02 2.03e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.05e-02 4.47e-02 0.37700 5.30e-02 0.374000 7.23e-01 1.22e-02
ACYL CHAIN REMODELLING OF PE 17 1.11e-01 2.43e-01 0.37700 2.77e-01 0.255000 4.78e-02 6.88e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 3.53e-03 2.03e-02 0.37700 3.46e-01 0.149000 1.26e-03 1.66e-01
LYSINE CATABOLISM 11 2.42e-01 4.12e-01 0.37700 2.72e-01 0.261000 1.18e-01 1.35e-01
SULFUR AMINO ACID METABOLISM 23 1.51e-02 5.76e-02 0.37600 3.40e-01 0.162000 4.79e-03 1.79e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 13 1.92e-01 3.54e-01 0.37400 2.61e-01 0.268000 1.03e-01 9.45e-02
PEROXISOMAL PROTEIN IMPORT 59 4.36e-04 4.54e-03 0.37200 2.91e-01 0.232000 1.13e-04 2.03e-03
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 7.85e-02 1.92e-01 0.37200 3.16e-01 0.197000 2.42e-02 1.60e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 8.47e-04 7.55e-03 0.37200 3.51e-01 0.122000 4.84e-04 2.26e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 9.08e-17 2.67e-14 0.37100 2.92e-01 0.229000 2.62e-17 2.83e-11
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 2.47e-01 4.19e-01 0.36900 -2.39e-01 -0.282000 1.70e-01 1.06e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 1.03e-03 8.68e-03 0.36900 2.01e-01 0.310000 1.60e-02 2.07e-04
G PROTEIN MEDIATED EVENTS 52 8.83e-05 1.30e-03 0.36700 1.51e-01 0.335000 5.95e-02 2.95e-05
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 4.15e-02 1.24e-01 0.36600 3.47e-01 0.117000 1.99e-02 4.34e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 6.07e-02 1.59e-01 0.36600 1.90e-01 0.313000 1.52e-01 1.81e-02
INTERFERON ALPHA BETA SIGNALING 53 2.21e-07 9.30e-06 0.36600 -3.63e-01 -0.047900 4.98e-06 5.47e-01
DARPP 32 EVENTS 23 4.56e-02 1.32e-01 0.36600 2.99e-01 0.211000 1.32e-02 8.01e-02
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 3.93e-02 1.19e-01 0.36400 9.62e-02 0.351000 5.33e-01 2.28e-02
ACTIVATION OF RAC1 13 2.09e-01 3.70e-01 0.36400 2.56e-01 0.259000 1.10e-01 1.06e-01
DNA METHYLATION 23 1.82e-02 6.68e-02 0.36300 -1.51e-01 -0.330000 2.09e-01 6.10e-03
REGULATION OF IFNG SIGNALING 13 2.03e-01 3.64e-01 0.36300 2.34e-01 0.277000 1.44e-01 8.34e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 2.08e-01 3.70e-01 0.36200 2.72e-01 0.240000 8.98e-02 1.35e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.40e-02 5.53e-02 0.36200 2.53e-01 0.259000 8.70e-03 7.25e-03
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.39e-01 4.10e-01 0.36100 2.94e-01 0.209000 9.16e-02 2.30e-01
MHC CLASS II ANTIGEN PRESENTATION 102 3.45e-07 1.36e-05 0.36000 3.11e-01 0.181000 5.60e-08 1.61e-03
INSULIN RECEPTOR RECYCLING 20 3.54e-02 1.12e-01 0.36000 3.25e-01 0.154000 1.19e-02 2.33e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 3.74e-02 1.15e-01 0.35800 2.12e-01 0.289000 6.20e-02 1.08e-02
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 1.57e-01 3.07e-01 0.35800 2.84e-01 0.218000 5.73e-02 1.44e-01
SYNTHESIS OF PA 29 2.94e-02 9.63e-02 0.35700 2.21e-01 0.281000 3.93e-02 8.94e-03
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 1.72e-02 6.39e-02 0.35700 2.26e-01 0.276000 2.27e-02 5.35e-03
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 1.14e-01 2.48e-01 0.35600 2.20e-01 0.280000 1.06e-01 3.99e-02
SIGNALING BY HIPPO 20 4.22e-02 1.25e-01 0.35500 1.57e-01 0.318000 2.24e-01 1.38e-02
PKA MEDIATED PHOSPHORYLATION OF CREB 19 9.57e-02 2.21e-01 0.35500 2.85e-01 0.211000 3.14e-02 1.12e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 2.88e-06 8.47e-05 0.35400 3.12e-01 0.168000 5.81e-07 6.95e-03
PROTEIN METHYLATION 17 7.77e-02 1.91e-01 0.35400 3.13e-01 0.165000 2.57e-02 2.38e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 6.72e-02 1.70e-01 0.35300 1.30e-01 0.328000 3.82e-01 2.76e-02
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.36e-01 2.82e-01 0.35300 2.05e-01 0.287000 1.55e-01 4.66e-02
CHONDROITIN SULFATE BIOSYNTHESIS 18 1.32e-01 2.76e-01 0.35200 2.52e-01 0.246000 6.42e-02 7.10e-02
RHOU GTPASE CYCLE 34 3.12e-04 3.59e-03 0.35100 7.15e-02 0.344000 4.71e-01 5.25e-04
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 4.50e-02 1.31e-01 0.35000 2.45e-01 0.250000 2.51e-02 2.23e-02
CD28 CO STIMULATION 31 1.99e-02 7.08e-02 0.34900 1.94e-01 0.290000 6.20e-02 5.14e-03
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 9.83e-10 7.72e-08 0.34900 2.66e-01 0.226000 4.81e-10 1.10e-07
GAP JUNCTION DEGRADATION 11 2.84e-01 4.57e-01 0.34900 2.70e-01 0.221000 1.21e-01 2.05e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 24 2.76e-02 9.19e-02 0.34800 -1.57e-01 -0.310000 1.82e-01 8.50e-03
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.81e-02 2.07e-01 0.34800 2.14e-01 0.274000 8.95e-02 2.98e-02
NEGATIVE REGULATION OF MET ACTIVITY 20 7.69e-02 1.90e-01 0.34600 1.85e-01 0.293000 1.53e-01 2.35e-02
G1 S SPECIFIC TRANSCRIPTION 26 5.64e-02 1.51e-01 0.34600 2.62e-01 0.226000 2.08e-02 4.65e-02
TELOMERE C STRAND SYNTHESIS INITIATION 13 2.46e-01 4.18e-01 0.34500 2.46e-01 0.241000 1.24e-01 1.32e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.36e-03 1.11e-02 0.34500 3.20e-01 0.129000 5.54e-04 1.64e-01
AUTOPHAGY 138 8.71e-08 4.54e-06 0.34400 2.80e-01 0.199000 1.30e-08 5.68e-05
IRON UPTAKE AND TRANSPORT 51 2.12e-03 1.45e-02 0.34200 2.84e-01 0.191000 4.53e-04 1.82e-02
DEFECTS IN COBALAMIN B12 METABOLISM 13 1.93e-01 3.55e-01 0.34200 1.81e-01 0.290000 2.58e-01 6.98e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 1.70e-01 3.22e-01 0.34200 1.81e-01 0.291000 2.42e-01 5.98e-02
COLLAGEN CHAIN TRIMERIZATION 41 4.91e-03 2.53e-02 0.34200 -1.75e-01 -0.294000 5.29e-02 1.15e-03
CARGO CONCENTRATION IN THE ER 31 1.58e-02 5.93e-02 0.34100 2.97e-01 0.168000 4.20e-03 1.06e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 2.78e-01 4.50e-01 0.34100 2.27e-01 0.254000 1.73e-01 1.27e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 3.12e-01 4.84e-01 0.33900 2.54e-01 0.225000 1.45e-01 1.96e-01
ACTIVATION OF SMO 16 6.62e-02 1.69e-01 0.33900 1.20e-01 0.317000 4.05e-01 2.83e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 1.14e-02 4.79e-02 0.33900 1.10e-01 0.320000 3.41e-01 5.58e-03
BUDDING AND MATURATION OF HIV VIRION 27 5.29e-02 1.45e-01 0.33800 2.65e-01 0.210000 1.71e-02 5.91e-02
AGGREPHAGY 34 1.11e-04 1.57e-03 0.33600 3.35e-01 0.022500 7.27e-04 8.20e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 1.75e-01 3.28e-01 0.33500 2.67e-01 0.202000 6.42e-02 1.62e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 3.26e-01 4.98e-01 0.33500 2.29e-01 0.244000 1.88e-01 1.62e-01
INOSITOL PHOSPHATE METABOLISM 46 1.90e-03 1.35e-02 0.33400 1.54e-01 0.297000 7.14e-02 4.90e-04
GLYCOSAMINOGLYCAN METABOLISM 113 8.28e-06 2.03e-04 0.33400 2.55e-01 0.216000 2.77e-06 7.39e-05
INTRAFLAGELLAR TRANSPORT 52 2.97e-06 8.52e-05 0.33400 3.32e-01 0.041000 3.48e-05 6.09e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 2.87e-01 4.61e-01 0.33400 -2.55e-01 -0.216000 1.26e-01 1.95e-01
EUKARYOTIC TRANSLATION ELONGATION 87 1.09e-05 2.51e-04 0.33400 -1.59e-01 -0.293000 1.06e-02 2.25e-06
TRANS GOLGI NETWORK VESICLE BUDDING 70 6.23e-04 6.12e-03 0.33300 2.06e-01 0.262000 2.93e-03 1.55e-04
AMINE LIGAND BINDING RECEPTORS 29 4.62e-02 1.33e-01 0.33300 2.04e-01 0.262000 5.69e-02 1.44e-02
COPII MEDIATED VESICLE TRANSPORT 66 7.79e-04 7.11e-03 0.33200 2.68e-01 0.197000 1.69e-04 5.72e-03
SELECTIVE AUTOPHAGY 71 5.73e-05 9.36e-04 0.33200 2.97e-01 0.147000 1.49e-05 3.17e-02
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 1.31e-06 4.04e-05 0.33100 -1.40e-01 -0.300000 1.86e-02 4.29e-07
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 2.58e-02 8.72e-02 0.32900 -1.19e-01 -0.307000 3.25e-01 1.07e-02
PENTOSE PHOSPHATE PATHWAY 13 2.57e-01 4.31e-01 0.32900 2.61e-01 0.200000 1.03e-01 2.12e-01
COMPLEX I BIOGENESIS 56 1.54e-03 1.21e-02 0.32800 -1.75e-01 -0.278000 2.37e-02 3.22e-04
G0 AND EARLY G1 25 8.81e-02 2.07e-01 0.32700 2.37e-01 0.226000 4.06e-02 5.07e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 2.38e-01 4.09e-01 0.32600 1.99e-01 0.259000 1.98e-01 9.39e-02
BIOTIN TRANSPORT AND METABOLISM 11 1.42e-02 5.55e-02 0.32600 -1.05e-01 0.309000 5.48e-01 7.63e-02
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 3.00e-01 4.73e-01 0.32600 1.63e-01 0.282000 3.73e-01 1.23e-01
FORMATION OF APOPTOSOME 10 3.55e-01 5.22e-01 0.32400 2.62e-01 0.190000 1.52e-01 2.97e-01
RAB GERANYLGERANYLATION 57 1.72e-03 1.26e-02 0.32300 2.73e-01 0.173000 3.60e-04 2.43e-02
DISEASES OF DNA REPAIR 11 3.28e-01 5.00e-01 0.32300 1.95e-01 0.257000 2.62e-01 1.39e-01
HSF1 ACTIVATION 25 5.05e-04 5.11e-03 0.32300 3.22e-01 -0.029200 5.38e-03 8.00e-01
VXPX CARGO TARGETING TO CILIUM 19 1.41e-01 2.89e-01 0.32300 1.89e-01 0.261000 1.53e-01 4.89e-02
DAG AND IP3 SIGNALING 40 5.95e-03 2.89e-02 0.32200 1.45e-01 0.287000 1.13e-01 1.67e-03
CONDENSATION OF PROPHASE CHROMOSOMES 30 1.07e-02 4.54e-02 0.32100 -1.15e-01 -0.300000 2.75e-01 4.50e-03
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 2.02e-01 3.63e-01 0.32100 2.16e-01 0.237000 1.23e-01 9.03e-02
MTOR SIGNALLING 40 2.08e-02 7.36e-02 0.32100 2.02e-01 0.249000 2.69e-02 6.47e-03
GABA RECEPTOR ACTIVATION 55 5.68e-03 2.81e-02 0.32100 2.38e-01 0.215000 2.24e-03 5.93e-03
MATURATION OF NUCLEOPROTEIN 10 1.18e-01 2.56e-01 0.32000 -3.16e-01 -0.050100 8.32e-02 7.84e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 13 2.95e-01 4.67e-01 0.32000 -2.38e-01 -0.214000 1.38e-01 1.81e-01
PARASITE INFECTION 54 1.71e-03 1.26e-02 0.32000 1.56e-01 0.279000 4.72e-02 3.95e-04
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 29 2.58e-02 8.72e-02 0.32000 -2.85e-01 -0.144000 7.90e-03 1.78e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 3.67e-01 5.33e-01 0.31900 1.88e-01 0.257000 3.03e-01 1.59e-01
G ALPHA Z SIGNALLING EVENTS 44 8.58e-03 3.80e-02 0.31800 2.69e-01 0.169000 2.04e-03 5.22e-02
SIGNALING BY HEDGEHOG 141 3.92e-07 1.49e-05 0.31700 2.65e-01 0.174000 5.58e-08 3.59e-04
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 84 3.90e-04 4.29e-03 0.31600 2.00e-01 0.244000 1.54e-03 1.09e-04
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 1.93e-03 1.37e-02 0.31500 -7.19e-02 -0.307000 4.68e-01 1.96e-03
PYRUVATE METABOLISM 27 8.89e-02 2.09e-01 0.31400 2.15e-01 0.229000 5.33e-02 3.97e-02
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 1.59e-03 1.23e-02 0.31400 2.62e-01 0.173000 3.31e-04 1.76e-02
SIGNAL AMPLIFICATION 31 3.58e-02 1.12e-01 0.31300 2.67e-01 0.164000 9.97e-03 1.15e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.98e-01 3.61e-01 0.31300 2.60e-01 0.175000 7.18e-02 2.26e-01
PROCESSING AND ACTIVATION OF SUMO 10 3.80e-01 5.43e-01 0.31300 2.53e-01 0.184000 1.66e-01 3.14e-01
PLASMA LIPOPROTEIN CLEARANCE 28 8.17e-02 1.97e-01 0.31300 2.32e-01 0.210000 3.39e-02 5.44e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 2.03e-04 2.57e-03 0.31200 2.47e-01 0.190000 4.60e-05 1.72e-03
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 5.72e-02 1.51e-01 0.31200 1.49e-01 0.274000 1.96e-01 1.78e-02
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 3.03e-04 3.54e-03 0.31200 1.93e-01 0.244000 1.71e-03 7.57e-05
METABOLISM OF CARBOHYDRATES 260 8.26e-11 1.08e-08 0.31100 2.38e-01 0.200000 3.75e-11 2.78e-08
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.67e-01 3.19e-01 0.31100 -2.98e-01 -0.087600 8.71e-02 6.15e-01
SYNTHESIS OF PE 13 2.96e-01 4.68e-01 0.31000 1.87e-01 0.248000 2.44e-01 1.22e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 1.23e-01 2.65e-01 0.31000 2.23e-01 0.215000 5.83e-02 6.84e-02
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 108 7.47e-05 1.14e-03 0.30900 2.03e-01 0.234000 2.72e-04 2.77e-05
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.90e-02 1.92e-01 0.30900 1.93e-01 0.242000 7.69e-02 2.70e-02
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 3.54e-03 2.03e-02 0.30900 1.64e-01 0.262000 3.55e-02 7.87e-04
PI METABOLISM 79 4.37e-05 7.68e-04 0.30800 1.25e-01 0.281000 5.40e-02 1.53e-05
PKMTS METHYLATE HISTONE LYSINES 51 2.98e-03 1.80e-02 0.30800 -2.72e-01 -0.143000 7.66e-04 7.64e-02
HSF1 DEPENDENT TRANSACTIVATION 33 9.26e-04 8.01e-03 0.30700 3.06e-01 0.033100 2.39e-03 7.42e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 1.49e-01 2.99e-01 0.30700 1.76e-01 0.251000 1.72e-01 5.16e-02
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 4.74e-02 1.34e-01 0.30600 2.19e-01 0.214000 2.33e-02 2.66e-02
MTORC1 MEDIATED SIGNALLING 24 1.30e-01 2.73e-01 0.30600 2.09e-01 0.223000 7.65e-02 5.86e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.09e-01 5.72e-01 0.30600 2.41e-01 0.188000 1.87e-01 3.03e-01
PHOSPHOLIPID METABOLISM 186 1.97e-08 1.16e-06 0.30500 1.70e-01 0.253000 6.54e-05 2.60e-09
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 7.75e-02 1.91e-01 0.30400 1.42e-01 0.269000 2.37e-01 2.56e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 5.13e-03 2.60e-02 0.30400 2.88e-01 0.096400 2.75e-03 3.17e-01
MEMBRANE TRAFFICKING 581 1.19e-21 7.01e-19 0.30400 1.98e-01 0.230000 3.56e-16 3.13e-21
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 2.40e-01 4.11e-01 0.30200 2.52e-01 0.167000 9.12e-02 2.62e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 8.83e-03 3.88e-02 0.30200 2.81e-01 0.111000 3.55e-03 2.47e-01
PRE NOTCH PROCESSING IN GOLGI 18 1.69e-01 3.21e-01 0.30200 1.59e-01 0.257000 2.42e-01 5.95e-02
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 8.10e-02 1.96e-01 0.30200 2.26e-01 0.200000 3.22e-02 5.75e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 4.73e-02 1.34e-01 0.30200 2.89e-01 0.086200 2.52e-02 5.05e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 23 1.34e-01 2.79e-01 0.30100 1.84e-01 0.239000 1.27e-01 4.77e-02
SARS COV 2 INFECTION 65 4.85e-03 2.53e-02 0.30100 2.15e-01 0.211000 2.78e-03 3.27e-03
TBC RABGAPS 43 2.48e-02 8.48e-02 0.30100 1.87e-01 0.236000 3.42e-02 7.49e-03
PRC2 METHYLATES HISTONES AND DNA 32 4.58e-02 1.33e-01 0.30000 -1.61e-01 -0.254000 1.15e-01 1.30e-02
SEROTONIN RECEPTORS 10 3.58e-01 5.26e-01 0.29900 2.60e-01 0.148000 1.54e-01 4.18e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 4.11e-02 1.24e-01 0.29800 3.80e-03 0.298000 9.80e-01 5.33e-02
REGULATION OF KIT SIGNALING 16 2.68e-01 4.40e-01 0.29800 1.95e-01 0.226000 1.77e-01 1.18e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 1.77e-05 3.60e-04 0.29800 1.93e-01 0.228000 1.27e-04 5.85e-06
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.92e-02 6.89e-02 0.29800 2.27e-01 0.193000 6.46e-03 2.10e-02
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.96e-01 3.59e-01 0.29700 1.94e-01 0.225000 1.33e-01 8.18e-02
INTEGRATION OF ENERGY METABOLISM 100 2.94e-04 3.50e-03 0.29700 2.25e-01 0.193000 9.88e-05 8.57e-04
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 4.32e-04 4.54e-03 0.29600 -1.32e-02 0.296000 8.97e-01 3.75e-03
VEGFR2 MEDIATED CELL PROLIFERATION 19 2.19e-01 3.85e-01 0.29600 2.15e-01 0.204000 1.04e-01 1.25e-01
INTERFERON GAMMA SIGNALING 73 1.04e-06 3.41e-05 0.29600 -2.94e-01 -0.039500 1.46e-05 5.60e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 2.89e-01 4.63e-01 0.29600 -2.52e-01 -0.155000 1.16e-01 3.33e-01
NUCLEOTIDE SALVAGE 21 1.09e-01 2.41e-01 0.29600 2.62e-01 0.138000 3.78e-02 2.74e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 2.13e-04 2.64e-03 0.29600 1.84e-01 0.232000 1.36e-03 5.26e-05
UNFOLDED PROTEIN RESPONSE UPR 85 8.55e-04 7.56e-03 0.29500 2.32e-01 0.182000 2.14e-04 3.66e-03
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 5.11e-02 1.41e-01 0.29500 -2.36e-01 -0.176000 1.55e-02 7.12e-02
RHOG GTPASE CYCLE 74 5.67e-05 9.36e-04 0.29500 9.94e-02 0.277000 1.39e-01 3.73e-05
HDACS DEACETYLATE HISTONES 49 2.14e-02 7.54e-02 0.29400 -2.07e-01 -0.210000 1.24e-02 1.11e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 7.54e-02 1.88e-01 0.29400 2.56e-01 0.144000 2.39e-02 2.03e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 58 3.14e-04 3.59e-03 0.29400 2.80e-01 0.089900 2.31e-04 2.36e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 9.31e-03 4.06e-02 0.29200 -2.89e-01 -0.035000 1.22e-02 7.62e-01
HDMS DEMETHYLATE HISTONES 30 4.31e-03 2.32e-02 0.29100 -2.88e-01 -0.039900 6.28e-03 7.05e-01
RHOBTB2 GTPASE CYCLE 23 1.27e-01 2.71e-01 0.29100 2.45e-01 0.157000 4.23e-02 1.91e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 5.58e-02 1.50e-01 0.29000 2.58e-01 0.132000 1.82e-02 2.27e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 3.81e-02 1.17e-01 0.29000 1.28e-01 0.260000 2.17e-01 1.23e-02
RHOJ GTPASE CYCLE 54 7.57e-04 7.01e-03 0.28900 9.11e-02 0.275000 2.47e-01 4.79e-04
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 3.91e-02 1.19e-01 0.28900 6.67e-02 0.282000 5.97e-01 2.55e-02
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 3.40e-03 1.99e-02 0.28800 1.91e-01 0.215000 4.20e-03 1.30e-03
DEADENYLATION OF MRNA 25 1.01e-01 2.29e-01 0.28800 1.48e-01 0.247000 2.01e-01 3.28e-02
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 3.54e-01 5.22e-01 0.28700 2.40e-01 0.158000 1.50e-01 3.44e-01
RHOB GTPASE CYCLE 67 1.14e-06 3.62e-05 0.28700 1.06e-02 0.287000 8.81e-01 4.84e-05
MITOPHAGY 29 6.23e-02 1.61e-01 0.28700 2.51e-01 0.140000 1.94e-02 1.92e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 8.87e-04 7.73e-03 0.28600 1.55e-01 0.241000 1.60e-02 1.78e-04
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 3.05e-01 4.77e-01 0.28600 -2.01e-01 -0.203000 1.64e-01 1.59e-01
PROTEIN LOCALIZATION 158 1.03e-06 3.41e-05 0.28500 2.42e-01 0.151000 1.54e-07 1.09e-03
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 182 1.64e-06 4.95e-05 0.28500 1.94e-01 0.209000 6.70e-06 1.24e-06
FATTY ACID METABOLISM 146 2.27e-05 4.46e-04 0.28400 1.92e-01 0.209000 6.07e-05 1.30e-05
PROLACTIN RECEPTOR SIGNALING 11 3.77e-01 5.42e-01 0.28400 2.43e-01 0.148000 1.63e-01 3.97e-01
HS GAG BIOSYNTHESIS 30 1.09e-01 2.41e-01 0.28400 2.11e-01 0.190000 4.56e-02 7.18e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.30e-01 5.03e-01 0.28400 2.61e-01 0.111000 1.53e-01 5.42e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 50 2.59e-02 8.72e-02 0.28300 -1.90e-01 -0.209000 1.99e-02 1.05e-02
FCGR3A MEDIATED IL10 SYNTHESIS 32 9.28e-02 2.17e-01 0.28300 1.83e-01 0.216000 7.32e-02 3.48e-02
CHOLESTEROL BIOSYNTHESIS 24 4.22e-02 1.25e-01 0.28300 2.70e-01 0.083200 2.19e-02 4.80e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 3.78e-01 5.42e-01 0.28200 -2.51e-01 -0.129000 1.70e-01 4.82e-01
GABA B RECEPTOR ACTIVATION 40 5.63e-02 1.51e-01 0.28200 2.03e-01 0.195000 2.61e-02 3.31e-02
SIALIC ACID METABOLISM 32 9.59e-02 2.21e-01 0.28100 2.14e-01 0.183000 3.64e-02 7.39e-02
THE PHOTOTRANSDUCTION CASCADE 22 4.14e-02 1.24e-01 0.28100 -6.55e-02 -0.273000 5.95e-01 2.66e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.76e-01 4.50e-01 0.28100 -2.22e-01 -0.172000 1.13e-01 2.19e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.80e-01 4.53e-01 0.27900 -2.30e-01 -0.158000 1.11e-01 2.73e-01
OPIOID SIGNALLING 87 1.18e-03 9.75e-03 0.27900 1.62e-01 0.227000 8.94e-03 2.51e-04
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 15 2.12e-01 3.76e-01 0.27900 -1.15e-01 -0.254000 4.40e-01 8.86e-02
NONSENSE MEDIATED DECAY NMD 109 7.03e-05 1.12e-03 0.27800 -1.38e-01 -0.241000 1.28e-02 1.37e-05
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 4.55e-01 6.20e-01 0.27700 1.79e-01 0.212000 3.04e-01 2.24e-01
RESOLUTION OF D LOOP STRUCTURES 31 1.17e-02 4.80e-02 0.27700 -2.70e-01 -0.061600 9.23e-03 5.53e-01
HEDGEHOG OFF STATE 106 5.66e-06 1.46e-04 0.27700 2.59e-01 0.096600 3.99e-06 8.60e-02
BLOOD GROUP SYSTEMS BIOSYNTHESIS 15 3.28e-01 5.00e-01 0.27600 1.65e-01 0.221000 2.67e-01 1.38e-01
NEPHRIN FAMILY INTERACTIONS 23 5.58e-02 1.50e-01 0.27600 8.14e-02 0.264000 4.99e-01 2.86e-02
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 15 1.37e-01 2.82e-01 0.27600 7.26e-02 0.266000 6.26e-01 7.45e-02
NUCLEAR IMPORT OF REV PROTEIN 32 1.99e-03 1.39e-02 0.27500 2.58e-03 0.275000 9.80e-01 7.13e-03
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 4.91e-03 2.53e-02 0.27400 1.10e-01 0.252000 1.71e-01 1.71e-03
TIGHT JUNCTION INTERACTIONS 16 3.11e-01 4.83e-01 0.27400 1.66e-01 0.219000 2.51e-01 1.30e-01
VESICLE MEDIATED TRANSPORT 613 1.95e-18 7.66e-16 0.27400 1.85e-01 0.202000 5.38e-15 1.57e-17
LAMININ INTERACTIONS 29 3.31e-02 1.06e-01 0.27400 -2.59e-01 -0.088400 1.57e-02 4.10e-01
RAC2 GTPASE CYCLE 87 8.72e-05 1.30e-03 0.27300 1.00e-01 0.254000 1.07e-01 4.24e-05
SYNTHESIS OF PC 26 1.69e-01 3.22e-01 0.27200 2.05e-01 0.180000 7.09e-02 1.13e-01
UNWINDING OF DNA 12 3.69e-01 5.35e-01 0.27200 1.38e-01 0.235000 4.09e-01 1.59e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 1.50e-01 2.99e-01 0.27200 1.24e-01 0.242000 3.23e-01 5.52e-02
INTEGRIN CELL SURFACE INTERACTIONS 75 6.08e-03 2.92e-02 0.27100 -2.06e-01 -0.177000 2.05e-03 8.16e-03
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 5.34e-02 1.46e-01 0.27100 1.23e-01 -0.241000 4.99e-01 1.86e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 1.46e-01 2.95e-01 0.27100 2.67e-01 0.048100 9.60e-02 7.64e-01
PEPTIDE HORMONE METABOLISM 60 1.84e-02 6.73e-02 0.27000 1.99e-01 0.183000 7.79e-03 1.40e-02
SCAVENGING BY CLASS A RECEPTORS 14 2.29e-02 7.96e-02 0.27000 9.28e-02 -0.253000 5.48e-01 1.01e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 3.87e-03 2.18e-02 0.27000 3.41e-02 0.268000 7.27e-01 6.13e-03
RAB REGULATION OF TRAFFICKING 119 1.58e-04 2.09e-03 0.27000 1.53e-01 0.222000 3.89e-03 2.93e-05
METABOLISM OF NUCLEOTIDES 92 9.72e-04 8.29e-03 0.26900 2.25e-01 0.148000 1.96e-04 1.39e-02
ATTENUATION PHASE 23 1.41e-03 1.13e-02 0.26900 2.43e-01 -0.117000 4.40e-02 3.31e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 2.56e-01 4.29e-01 0.26900 -1.59e-01 -0.218000 2.31e-01 1.01e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 243 1.01e-07 4.76e-06 0.26900 1.74e-01 0.205000 3.13e-06 3.94e-08
FORMATION OF THE CORNIFIED ENVELOPE 31 1.12e-04 1.57e-03 0.26900 1.33e-01 -0.233000 1.99e-01 2.47e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 9.26e-07 3.20e-05 0.26900 2.67e-01 -0.025300 1.73e-04 7.22e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 3.42e-01 5.12e-01 0.26800 2.40e-01 0.120000 1.51e-01 4.70e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 7.28e-02 1.83e-01 0.26800 1.31e-04 0.268000 9.99e-01 8.25e-02
CELLULAR RESPONSE TO HEAT STRESS 94 2.17e-03 1.46e-02 0.26800 1.97e-01 0.181000 9.47e-04 2.43e-03
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 2.35e-02 8.10e-02 0.26800 2.19e-01 0.153000 6.26e-03 5.57e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 27 9.32e-02 2.17e-01 0.26700 -1.22e-01 -0.238000 2.74e-01 3.22e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 8.43e-02 2.02e-01 0.26700 2.58e-01 0.071400 4.62e-02 5.81e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.14e-02 4.79e-02 0.26600 2.65e-01 0.027900 1.53e-02 7.98e-01
SARS COV 1 INFECTION 48 4.28e-02 1.26e-01 0.26600 1.73e-01 0.202000 3.84e-02 1.53e-02
EPHB MEDIATED FORWARD SIGNALING 42 6.48e-02 1.66e-01 0.26600 1.75e-01 0.200000 4.92e-02 2.49e-02
SIGNALING BY WNT IN CANCER 31 6.41e-02 1.65e-01 0.26600 1.18e-01 0.238000 2.54e-01 2.17e-02
CELLULAR HEXOSE TRANSPORT 12 1.59e-01 3.09e-01 0.26600 3.46e-02 0.264000 8.36e-01 1.14e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 2.78e-01 4.50e-01 0.26600 -1.03e-01 -0.245000 5.20e-01 1.26e-01
PROTEIN UBIQUITINATION 70 7.75e-03 3.51e-02 0.26500 2.14e-01 0.156000 1.92e-03 2.37e-02
MITOTIC TELOPHASE CYTOKINESIS 13 2.80e-02 9.27e-02 0.26500 -1.13e-01 0.240000 4.82e-01 1.34e-01
SIGNAL TRANSDUCTION BY L1 21 2.25e-01 3.91e-01 0.26500 2.17e-01 0.151000 8.46e-02 2.31e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 3.00e-02 9.73e-02 0.26400 -1.42e-02 0.264000 9.17e-01 5.25e-02
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 1.23e-04 1.69e-03 0.26400 -7.15e-02 0.254000 4.52e-01 7.44e-03
TRIGLYCERIDE CATABOLISM 14 3.06e-01 4.77e-01 0.26400 2.34e-01 0.122000 1.29e-01 4.29e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 2.95e-02 9.64e-02 0.26400 2.53e-01 0.074500 1.63e-02 4.80e-01
HEDGEHOG LIGAND BIOGENESIS 61 2.76e-03 1.72e-02 0.26400 2.43e-01 0.102000 1.03e-03 1.67e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 1.38e-03 1.12e-02 0.26300 2.28e-01 0.132000 3.05e-04 3.71e-02
ERYTHROPOIETIN ACTIVATES RAS 13 4.35e-01 5.98e-01 0.26300 1.99e-01 0.172000 2.14e-01 2.83e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 72 6.07e-03 2.92e-02 0.26200 2.18e-01 0.145000 1.40e-03 3.36e-02
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.68e-02 2.21e-01 0.26100 1.29e-02 0.261000 9.33e-01 9.07e-02
FCERI MEDIATED MAPK ACTIVATION 28 1.73e-01 3.27e-01 0.26100 1.74e-01 0.195000 1.10e-01 7.48e-02
EXTRA NUCLEAR ESTROGEN SIGNALING 68 4.95e-03 2.53e-02 0.26100 2.27e-01 0.129000 1.20e-03 6.59e-02
RNA POLYMERASE III CHAIN ELONGATION 18 6.14e-02 1.60e-01 0.26100 -2.50e-02 -0.260000 8.54e-01 5.67e-02
RMTS METHYLATE HISTONE ARGININES 46 3.10e-02 1.00e-01 0.26000 -1.33e-01 -0.224000 1.20e-01 8.60e-03
ERK MAPK TARGETS 22 4.76e-02 1.34e-01 0.26000 4.33e-02 0.256000 7.25e-01 3.74e-02
INTERLEUKIN 10 SIGNALING 19 2.69e-01 4.42e-01 0.25900 -2.15e-01 -0.145000 1.05e-01 2.74e-01
RESPIRATORY ELECTRON TRANSPORT 102 2.92e-04 3.50e-03 0.25900 -1.22e-01 -0.228000 3.39e-02 6.75e-05
METABOLISM OF POLYAMINES 57 2.24e-03 1.50e-02 0.25800 2.46e-01 0.079700 1.34e-03 2.98e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 1.43e-01 2.91e-01 0.25800 -2.40e-02 0.257000 8.95e-01 1.59e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 7.87e-02 1.92e-01 0.25800 6.80e-02 -0.249000 6.96e-01 1.53e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 17 2.33e-01 4.03e-01 0.25700 -2.33e-01 -0.110000 9.68e-02 4.33e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 4.87e-01 6.47e-01 0.25700 -1.82e-01 -0.181000 2.74e-01 2.77e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 1.67e-01 3.19e-01 0.25700 2.35e-01 0.103000 6.87e-02 4.27e-01
REGULATION OF INSULIN SECRETION 72 1.07e-02 4.55e-02 0.25600 2.03e-01 0.157000 2.96e-03 2.11e-02
PROTEIN FOLDING 90 1.33e-05 2.90e-04 0.25600 2.50e-01 0.053600 4.07e-05 3.80e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 5.71e-02 1.51e-01 0.25500 -2.43e-01 -0.077000 2.86e-02 4.89e-01
SIGNALLING TO ERKS 33 1.13e-01 2.48e-01 0.25400 1.43e-01 0.210000 1.55e-01 3.70e-02
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 9.69e-02 2.21e-01 0.25400 2.30e-01 0.108000 3.56e-02 3.22e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 24 1.97e-01 3.61e-01 0.25400 2.13e-01 0.138000 7.15e-02 2.41e-01
MITOTIC METAPHASE AND ANAPHASE 207 5.72e-06 1.46e-04 0.25100 1.93e-01 0.161000 1.78e-06 6.75e-05
METABOLISM OF LIPIDS 616 1.65e-16 3.89e-14 0.25100 1.52e-01 0.200000 1.47e-10 3.16e-17
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 3.91e-02 1.19e-01 0.25000 1.36e-01 0.210000 1.00e-01 1.09e-02
AMINO ACIDS REGULATE MTORC1 51 5.38e-02 1.47e-01 0.25000 1.86e-01 0.167000 2.14e-02 3.91e-02
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 101 5.08e-04 5.11e-03 0.24900 1.15e-01 0.221000 4.51e-02 1.23e-04
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 3.34e-03 1.97e-02 0.24900 2.32e-01 0.090200 1.43e-03 2.16e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 4.10e-01 5.73e-01 0.24900 1.53e-01 0.196000 3.04e-01 1.88e-01
GPVI MEDIATED ACTIVATION CASCADE 31 1.32e-01 2.76e-01 0.24700 1.32e-01 0.209000 2.02e-01 4.43e-02
RHOC GTPASE CYCLE 73 1.69e-04 2.21e-03 0.24700 4.80e-02 0.242000 4.79e-01 3.48e-04
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 4.15e-01 5.79e-01 0.24600 9.01e-02 0.229000 6.22e-01 2.10e-01
HEME BIOSYNTHESIS 13 3.32e-01 5.04e-01 0.24600 9.47e-02 0.227000 5.55e-01 1.56e-01
TRIGLYCERIDE BIOSYNTHESIS 10 1.37e-01 2.82e-01 0.24600 -5.03e-02 0.241000 7.83e-01 1.87e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 12 3.48e-01 5.15e-01 0.24600 2.29e-01 0.089100 1.70e-01 5.93e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 2.62e-01 4.33e-01 0.24400 9.37e-02 0.226000 5.16e-01 1.18e-01
ABC TRANSPORTER DISORDERS 69 1.90e-03 1.35e-02 0.24400 2.30e-01 0.082300 9.63e-04 2.38e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 20 3.13e-01 4.84e-01 0.24300 1.43e-01 0.196000 2.67e-01 1.29e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 5.92e-03 2.89e-02 0.24300 3.19e-03 0.243000 9.74e-01 1.43e-02
CGMP EFFECTS 15 3.80e-01 5.43e-01 0.24200 -2.07e-01 -0.126000 1.65e-01 3.98e-01
KERATINIZATION 32 4.96e-04 5.07e-03 0.24200 1.19e-01 -0.211000 2.45e-01 3.89e-02
RND2 GTPASE CYCLE 39 6.98e-03 3.24e-02 0.24200 3.10e-02 0.240000 7.38e-01 9.48e-03
BILE ACID AND BILE SALT METABOLISM 26 1.56e-01 3.06e-01 0.24200 1.11e-01 0.215000 3.27e-01 5.77e-02
INTERLEUKIN 6 SIGNALING 10 5.61e-01 7.05e-01 0.24200 1.43e-01 0.195000 4.34e-01 2.85e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 7.56e-03 3.44e-02 0.24100 1.71e-01 0.170000 4.42e-03 4.60e-03
PLATELET ACTIVATION SIGNALING AND AGGREGATION 224 8.17e-06 2.03e-04 0.24100 1.63e-01 0.177000 2.57e-05 5.20e-06
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 3.13e-01 4.84e-01 0.24100 1.64e-01 0.176000 1.84e-01 1.52e-01
NUCLEOBASE CATABOLISM 31 1.86e-01 3.47e-01 0.24000 1.86e-01 0.153000 7.37e-02 1.41e-01
RHO GTPASES ACTIVATE FORMINS 119 1.90e-03 1.35e-02 0.24000 1.59e-01 0.180000 2.70e-03 7.20e-04
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 3.18e-03 1.89e-02 0.24000 -4.43e-02 0.236000 6.70e-01 2.30e-02
GLUCOSE METABOLISM 81 1.54e-02 5.83e-02 0.23900 1.69e-01 0.169000 8.65e-03 8.61e-03
RHOBTB1 GTPASE CYCLE 23 1.95e-01 3.58e-01 0.23800 1.06e-01 0.214000 3.78e-01 7.63e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.96e-01 5.61e-01 0.23800 9.56e-02 0.218000 5.66e-01 1.90e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 4.64e-03 2.44e-02 0.23800 -4.72e-02 0.234000 6.60e-01 2.95e-02
SIGNALING BY NODAL 15 9.70e-02 2.21e-01 0.23800 -2.38e-01 0.010100 1.11e-01 9.46e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 2.59e-01 4.32e-01 0.23800 1.18e-01 0.206000 3.48e-01 1.02e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 6.82e-02 1.72e-01 0.23800 2.11e-01 0.109000 2.25e-02 2.39e-01
RHOQ GTPASE CYCLE 57 4.22e-04 4.48e-03 0.23800 1.29e-02 0.237000 8.66e-01 1.96e-03
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 4.12e-03 2.23e-02 0.23600 1.79e-01 0.154000 1.40e-03 5.96e-03
INHIBITION OF DNA RECOMBINATION AT TELOMERE 38 1.86e-02 6.79e-02 0.23600 -5.14e-02 -0.230000 5.83e-01 1.40e-02
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 2.18e-02 7.61e-02 0.23600 1.71e-01 0.162000 9.95e-03 1.46e-02
EGFR DOWNREGULATION 28 2.42e-01 4.12e-01 0.23500 1.74e-01 0.159000 1.11e-01 1.46e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 25 3.63e-02 1.13e-01 0.23500 -1.42e-02 -0.235000 9.02e-01 4.23e-02
NEUTROPHIL DEGRANULATION 386 8.34e-10 7.55e-08 0.23500 1.92e-01 0.135000 1.12e-10 5.22e-06
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 2.23e-01 3.89e-01 0.23400 9.96e-02 0.212000 4.29e-01 9.23e-02
RHOD GTPASE CYCLE 51 1.44e-02 5.60e-02 0.23400 8.00e-02 0.220000 3.23e-01 6.50e-03
HIV ELONGATION ARREST AND RECOVERY 32 8.78e-02 2.07e-01 0.23400 -9.07e-02 -0.216000 3.75e-01 3.48e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.05e-01 3.66e-01 0.23400 -7.15e-02 -0.222000 5.99e-01 1.02e-01
NRAGE SIGNALS DEATH THROUGH JNK 54 1.04e-04 1.51e-03 0.23300 -3.58e-02 0.231000 6.49e-01 3.37e-03
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 9.84e-02 2.24e-01 0.23300 2.23e-01 0.069600 4.93e-02 5.39e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 3.42e-01 5.12e-01 0.23300 1.99e-01 0.122000 1.44e-01 3.72e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 3.69e-01 5.35e-01 0.23300 1.74e-01 0.155000 1.77e-01 2.32e-01
MITOTIC SPINDLE CHECKPOINT 97 3.25e-03 1.92e-02 0.23300 1.21e-01 0.199000 3.94e-02 7.26e-04
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 3.15e-02 1.02e-01 0.23300 5.09e-02 0.227000 6.08e-01 2.20e-02
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 3.37e-01 5.10e-01 0.23200 1.54e-01 0.174000 2.13e-01 1.58e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.72e-02 1.34e-01 0.23200 1.32e-01 0.191000 8.86e-02 1.36e-02
SUMOYLATION OF SUMOYLATION PROTEINS 33 6.07e-03 2.92e-02 0.23200 -1.91e-02 0.231000 8.49e-01 2.18e-02
PLATELET CALCIUM HOMEOSTASIS 26 5.74e-03 2.83e-02 0.23100 -7.98e-02 0.217000 4.81e-01 5.52e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 3.15e-01 4.87e-01 0.23100 1.86e-01 0.138000 1.31e-01 2.63e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 2.68e-02 8.97e-02 0.23100 7.37e-02 0.219000 4.03e-01 1.30e-02
GP1B IX V ACTIVATION SIGNALLING 11 5.81e-01 7.21e-01 0.23100 -1.50e-01 -0.175000 3.90e-01 3.14e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.23e-01 4.95e-01 0.22900 -1.94e-01 -0.122000 1.33e-01 3.45e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 2.42e-01 4.12e-01 0.22900 1.27e-01 0.191000 2.63e-01 9.20e-02
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 3.71e-01 5.36e-01 0.22900 1.09e-01 0.201000 4.50e-01 1.63e-01
INTERLEUKIN 17 SIGNALING 68 8.04e-03 3.60e-02 0.22900 9.13e-02 0.210000 1.93e-01 2.82e-03
NEDDYLATION 217 1.44e-05 3.03e-04 0.22900 1.85e-01 0.134000 2.56e-06 7.07e-04
TNF SIGNALING 43 1.20e-01 2.59e-01 0.22800 1.43e-01 0.178000 1.05e-01 4.35e-02
SIGNALING BY NTRKS 129 1.50e-03 1.18e-02 0.22800 1.37e-01 0.183000 7.39e-03 3.46e-04
METABOLISM OF COFACTORS 19 2.66e-02 8.93e-02 0.22800 7.66e-02 -0.214000 5.63e-01 1.06e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 1.54e-01 3.04e-01 0.22800 -1.12e-02 0.227000 9.44e-01 1.56e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 83 2.73e-04 3.32e-03 0.22800 4.72e-02 0.223000 4.58e-01 4.58e-04
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 9.65e-02 2.21e-01 0.22700 2.02e-01 0.103000 3.34e-02 2.76e-01
MUCOPOLYSACCHARIDOSES 11 5.98e-01 7.32e-01 0.22700 1.58e-01 0.162000 3.63e-01 3.51e-01
RHOA GTPASE CYCLE 141 5.47e-06 1.46e-04 0.22700 6.44e-02 0.217000 1.87e-01 8.35e-06
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 4.67e-01 6.29e-01 0.22700 1.34e-01 0.183000 3.70e-01 2.19e-01
REGULATION OF SIGNALING BY CBL 22 1.36e-01 2.82e-01 0.22700 5.80e-02 0.219000 6.38e-01 7.53e-02
SIGNALING BY FGFR3 34 1.99e-01 3.61e-01 0.22600 1.72e-01 0.147000 8.24e-02 1.38e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 2.35e-01 4.05e-01 0.22600 9.20e-02 0.207000 4.66e-01 1.01e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1225 8.15e-24 9.59e-21 0.22600 1.64e-01 0.156000 7.90e-22 8.57e-20
NUCLEAR ENVELOPE BREAKDOWN 49 1.01e-02 4.34e-02 0.22600 5.23e-02 0.220000 5.27e-01 7.79e-03
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.26e-01 2.69e-01 0.22500 -2.03e-01 -0.097100 4.72e-02 3.42e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 51 5.02e-02 1.39e-01 0.22500 -1.96e-01 -0.109000 1.52e-02 1.77e-01
PROCESSING OF SMDT1 16 3.33e-01 5.06e-01 0.22400 2.06e-01 0.089400 1.54e-01 5.36e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 5.59e-03 2.79e-02 0.22400 2.12e-01 0.072300 2.88e-03 3.10e-01
SIGNALING BY RETINOIC ACID 33 2.00e-01 3.62e-01 0.22400 1.35e-01 0.179000 1.80e-01 7.54e-02
SIGNALING BY VEGF 103 5.29e-03 2.67e-02 0.22400 1.27e-01 0.185000 2.62e-02 1.22e-03
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.86e-01 7.22e-01 0.22300 1.19e-01 0.189000 5.13e-01 3.01e-01
SEPARATION OF SISTER CHROMATIDS 166 4.73e-04 4.89e-03 0.22300 1.71e-01 0.142000 1.40e-04 1.55e-03
PECAM1 INTERACTIONS 12 2.15e-01 3.78e-01 0.22300 1.63e-03 0.223000 9.92e-01 1.82e-01
BASE EXCISION REPAIR AP SITE FORMATION 32 1.02e-01 2.30e-01 0.22200 -8.20e-02 -0.207000 4.22e-01 4.29e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 7.62e-02 1.89e-01 0.22200 2.89e-02 0.221000 8.07e-01 6.15e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 6.70e-03 3.14e-02 0.22200 2.21e-01 0.026200 9.65e-03 7.59e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.32e-01 2.76e-01 0.22200 -2.19e-01 0.036900 1.72e-01 8.18e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 5.59e-02 1.50e-01 0.22200 1.73e-01 0.138000 1.84e-02 5.94e-02
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 2.40e-01 4.11e-01 0.22100 -2.17e-01 -0.044400 1.46e-01 7.66e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 8.66e-02 2.06e-01 0.22100 2.16e-01 -0.048300 1.48e-01 7.46e-01
ACYL CHAIN REMODELLING OF PC 17 4.56e-01 6.20e-01 0.22100 1.72e-01 0.140000 2.21e-01 3.19e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.18e-01 3.84e-01 0.22100 1.87e-01 0.118000 8.12e-02 2.72e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.30e-01 2.73e-01 0.22100 -5.92e-02 0.213000 7.23e-01 2.02e-01
INTEGRIN SIGNALING 24 1.99e-01 3.61e-01 0.22100 8.65e-02 0.203000 4.63e-01 8.48e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 4.08e-01 5.71e-01 0.22100 1.82e-01 0.125000 1.81e-01 3.60e-01
G ALPHA Q SIGNALLING EVENTS 153 6.05e-04 6.04e-03 0.22100 1.80e-01 0.127000 1.24e-04 6.54e-03
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 2.44e-02 8.37e-02 0.22100 4.94e-02 0.215000 5.85e-01 1.73e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 3.43e-03 1.99e-02 0.22000 2.07e-01 0.076000 1.61e-03 2.46e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.54e-01 3.04e-01 0.22000 1.66e-01 0.145000 6.34e-02 1.04e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 4.18e-04 4.47e-03 0.22000 -9.42e-02 -0.199000 6.92e-02 1.23e-04
SIGNALING BY NTRK2 TRKB 24 2.15e-01 3.78e-01 0.22000 9.05e-02 0.200000 4.43e-01 8.99e-02
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 64 6.67e-03 3.14e-02 0.21900 -2.09e-01 -0.066200 3.80e-03 3.60e-01
HYALURONAN METABOLISM 15 5.17e-01 6.72e-01 0.21900 1.48e-01 0.162000 3.20e-01 2.78e-01
COSTIMULATION BY THE CD28 FAMILY 50 6.70e-02 1.70e-01 0.21900 1.11e-01 0.189000 1.76e-01 2.06e-02
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.57e-01 6.20e-01 0.21900 1.54e-01 0.156000 2.59e-01 2.53e-01
HOST INTERACTIONS OF HIV FACTORS 125 4.47e-03 2.37e-02 0.21900 1.58e-01 0.151000 2.24e-03 3.57e-03
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 1.42e-02 5.55e-02 0.21900 -2.17e-01 -0.028400 1.63e-02 7.53e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 4.00e-01 5.64e-01 0.21800 6.75e-02 0.207000 6.86e-01 2.14e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 8.63e-02 2.05e-01 0.21800 -1.53e-01 0.155000 3.60e-01 3.52e-01
METABOLISM OF STEROIDS 116 6.53e-03 3.10e-02 0.21700 1.40e-01 0.165000 9.06e-03 2.15e-03
MYD88 INDEPENDENT TLR4 CASCADE 93 1.09e-02 4.61e-02 0.21700 1.20e-01 0.180000 4.61e-02 2.66e-03
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.54e-01 3.04e-01 0.21600 1.57e-01 0.149000 7.24e-02 8.65e-02
SIGNALING BY BMP 25 1.45e-01 2.94e-01 0.21600 6.35e-02 0.207000 5.82e-01 7.37e-02
HEDGEHOG ON STATE 82 1.88e-02 6.82e-02 0.21600 1.80e-01 0.119000 4.83e-03 6.29e-02
PI 3K CASCADE FGFR2 17 1.91e-01 3.53e-01 0.21600 -2.13e-01 -0.032800 1.28e-01 8.15e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 3.79e-01 5.42e-01 0.21600 -2.13e-01 -0.033100 2.44e-01 8.56e-01
SLC TRANSPORTER DISORDERS 75 8.76e-04 7.70e-03 0.21600 3.73e-02 0.212000 5.77e-01 1.49e-03
REDUCTION OF CYTOSOLIC CA LEVELS 12 9.66e-02 2.21e-01 0.21500 -1.77e-01 0.122000 2.88e-01 4.63e-01
G ALPHA I SIGNALLING EVENTS 204 2.13e-04 2.64e-03 0.21500 1.54e-01 0.149000 1.47e-04 2.38e-04
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 6.29e-01 7.52e-01 0.21400 1.60e-01 0.143000 3.59e-01 4.11e-01
RND1 GTPASE CYCLE 38 3.46e-02 1.10e-01 0.21400 4.36e-02 0.210000 6.42e-01 2.52e-02
FC EPSILON RECEPTOR FCERI SIGNALING 123 1.36e-03 1.11e-02 0.21400 1.88e-01 0.103000 3.19e-04 4.93e-02
FGFR2 MUTANT RECEPTOR ACTIVATION 27 2.91e-01 4.64e-01 0.21400 -1.25e-01 -0.174000 2.62e-01 1.18e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 1.66e-01 3.19e-01 0.21400 1.92e-01 0.094000 6.38e-02 3.65e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 6.52e-02 1.67e-01 0.21400 -1.41e-01 -0.161000 4.98e-02 2.50e-02
MEIOTIC RECOMBINATION 41 9.91e-02 2.25e-01 0.21300 -9.55e-02 -0.190000 2.90e-01 3.49e-02
NEUROTRANSMITTER RELEASE CYCLE 48 5.70e-02 1.51e-01 0.21300 8.87e-02 0.194000 2.88e-01 2.04e-02
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 7.39e-03 3.40e-02 0.21200 -1.75e-01 0.120000 1.22e-01 2.91e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 1.47e-01 2.97e-01 0.21200 1.97e-01 0.080300 6.25e-02 4.47e-01
SHC1 EVENTS IN EGFR SIGNALING 11 1.20e-01 2.59e-01 0.21200 1.55e-01 -0.145000 3.75e-01 4.06e-01
FCERI MEDIATED NF KB ACTIVATION 76 1.74e-03 1.27e-02 0.21100 2.06e-01 0.046400 1.90e-03 4.84e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.16e-01 6.72e-01 0.21100 1.37e-01 0.160000 3.41e-01 2.67e-01
KINESINS 47 3.58e-02 1.12e-01 0.21100 2.00e-01 0.065900 1.76e-02 4.35e-01
SIGNALING BY EGFR 47 1.40e-01 2.87e-01 0.21100 1.32e-01 0.164000 1.16e-01 5.20e-02
RAC3 GTPASE CYCLE 90 2.83e-03 1.75e-02 0.21100 7.50e-02 0.197000 2.19e-01 1.25e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.81e-04 2.32e-03 0.21000 -4.82e-02 -0.205000 3.92e-01 2.74e-04
DOWNSTREAM SIGNAL TRANSDUCTION 29 1.67e-01 3.19e-01 0.20900 7.99e-02 0.194000 4.57e-01 7.12e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 1.25e-01 2.68e-01 0.20900 -2.06e-01 0.034600 1.66e-01 8.16e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 33 1.02e-01 2.30e-01 0.20900 6.56e-02 0.198000 5.14e-01 4.91e-02
NEURONAL SYSTEM 370 5.28e-07 1.88e-05 0.20800 1.37e-01 0.156000 6.01e-06 2.59e-07
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 35 1.04e-01 2.33e-01 0.20800 -7.25e-02 -0.195000 4.58e-01 4.60e-02
MITOTIC G1 PHASE AND G1 S TRANSITION 142 2.03e-03 1.41e-02 0.20700 1.71e-01 0.117000 4.35e-04 1.64e-02
TRIGLYCERIDE METABOLISM 24 3.46e-01 5.15e-01 0.20700 1.16e-01 0.172000 3.27e-01 1.45e-01
EPH EPHRIN SIGNALING 92 2.62e-02 8.80e-02 0.20700 1.58e-01 0.133000 8.91e-03 2.70e-02
G BETA GAMMA SIGNALLING THROUGH CDC42 19 1.39e-01 2.86e-01 0.20700 2.06e-01 0.010400 1.20e-01 9.38e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 5.86e-01 7.22e-01 0.20600 -1.64e-01 -0.124000 3.06e-01 4.37e-01
SIGNALING BY SCF KIT 41 1.62e-01 3.14e-01 0.20600 1.12e-01 0.172000 2.13e-01 5.63e-02
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 6.32e-01 7.53e-01 0.20500 1.44e-01 0.146000 3.86e-01 3.81e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 4.76e-01 6.35e-01 0.20500 1.33e-01 0.156000 3.17e-01 2.38e-01
RND3 GTPASE CYCLE 38 9.88e-02 2.25e-01 0.20500 7.45e-02 0.191000 4.27e-01 4.19e-02
REGULATION OF TNFR1 SIGNALING 34 2.60e-01 4.33e-01 0.20400 1.26e-01 0.160000 2.03e-01 1.06e-01
INTERLEUKIN 37 SIGNALING 18 3.09e-01 4.81e-01 0.20400 6.58e-02 0.193000 6.29e-01 1.56e-01
METABOLISM OF PORPHYRINS 19 2.84e-01 4.57e-01 0.20400 6.36e-02 0.194000 6.31e-01 1.44e-01
REGULATION OF RAS BY GAPS 66 1.58e-02 5.93e-02 0.20300 1.91e-01 0.068900 7.18e-03 3.33e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 1.17e-02 4.80e-02 0.20300 1.39e-01 0.148000 8.99e-03 5.21e-03
PINK1 PRKN MEDIATED MITOPHAGY 22 2.50e-01 4.23e-01 0.20300 1.91e-01 0.067900 1.21e-01 5.81e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 2.01e-01 3.63e-01 0.20200 1.80e-01 0.092600 7.79e-02 3.65e-01
SHC MEDIATED CASCADE FGFR4 13 1.07e-01 2.39e-01 0.20200 1.15e-01 -0.167000 4.74e-01 2.98e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 1.40e-01 2.88e-01 0.20200 1.57e-01 0.126000 5.19e-02 1.19e-01
RORA ACTIVATES GENE EXPRESSION 18 5.56e-02 1.50e-01 0.20100 -1.80e-01 0.089400 1.85e-01 5.11e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 3.87e-01 5.49e-01 0.20100 1.41e-01 0.143000 2.14e-01 2.08e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 6.66e-02 1.70e-01 0.20100 1.80e-01 -0.089400 2.00e-01 5.23e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 49 2.31e-02 8.01e-02 0.20000 -4.13e-02 -0.196000 6.17e-01 1.76e-02
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 5.98e-02 1.57e-01 0.20000 -1.96e-01 -0.042600 3.94e-02 6.54e-01
TRNA PROCESSING IN THE NUCLEUS 56 4.89e-02 1.37e-01 0.20000 8.08e-02 0.183000 2.96e-01 1.79e-02
CD209 DC SIGN SIGNALING 18 5.16e-01 6.72e-01 0.20000 1.31e-01 0.151000 3.35e-01 2.69e-01
GPCR LIGAND BINDING 268 3.26e-06 9.15e-05 0.20000 1.76e-01 0.093400 6.95e-07 8.56e-03
ABC FAMILY PROTEINS MEDIATED TRANSPORT 94 1.73e-02 6.40e-02 0.19900 1.70e-01 0.104000 4.43e-03 8.07e-02
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 144 5.31e-03 2.67e-02 0.19900 1.30e-01 0.151000 7.08e-03 1.83e-03
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 2.90e-01 4.64e-01 0.19900 2.19e-02 0.198000 8.87e-01 2.01e-01
MISMATCH REPAIR 15 2.08e-01 3.70e-01 0.19900 -2.63e-03 0.199000 9.86e-01 1.83e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 191 7.29e-05 1.14e-03 0.19900 8.61e-02 0.179000 4.04e-02 2.06e-05
DEGRADATION OF GLI1 BY THE PROTEASOME 57 8.80e-03 3.88e-02 0.19900 1.96e-01 0.029200 1.04e-02 7.03e-01
LGI ADAM INTERACTIONS 14 1.66e-01 3.19e-01 0.19800 3.86e-02 -0.195000 8.03e-01 2.07e-01
DSCAM INTERACTIONS 11 2.06e-01 3.68e-01 0.19800 -1.87e-01 0.065300 2.83e-01 7.08e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 97 3.82e-03 2.16e-02 0.19800 7.02e-02 0.185000 2.32e-01 1.68e-03
HDR THROUGH MMEJ ALT NHEJ 10 2.22e-01 3.88e-01 0.19700 -8.04e-02 0.180000 6.60e-01 3.24e-01
NETRIN 1 SIGNALING 50 1.25e-02 5.04e-02 0.19600 1.92e-02 0.196000 8.15e-01 1.68e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 9.35e-02 2.17e-01 0.19600 1.96e-01 -0.004560 1.04e-01 9.70e-01
METAL ION SLC TRANSPORTERS 25 2.53e-01 4.27e-01 0.19600 1.82e-01 0.072600 1.16e-01 5.30e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 4.09e-03 2.23e-02 0.19500 1.95e-01 -0.004050 1.31e-02 9.59e-01
STRIATED MUSCLE CONTRACTION 26 1.97e-01 3.61e-01 0.19500 -1.86e-01 -0.058000 1.00e-01 6.09e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 3.39e-01 5.11e-01 0.19500 1.16e-01 0.157000 2.79e-01 1.44e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 3.09e-03 1.85e-02 0.19500 1.90e-01 0.042000 3.11e-03 5.13e-01
CILIUM ASSEMBLY 192 4.75e-05 8.22e-04 0.19500 1.79e-01 0.076100 1.92e-05 6.95e-02
REGULATION OF BACH1 ACTIVITY 11 6.79e-01 7.88e-01 0.19500 1.26e-01 0.148000 4.69e-01 3.95e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 3.72e-01 5.36e-01 0.19400 1.30e-02 0.194000 9.41e-01 2.66e-01
STABILIZATION OF P53 54 3.94e-03 2.18e-02 0.19400 1.94e-01 -0.006590 1.36e-02 9.33e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 67 7.60e-02 1.89e-01 0.19400 1.60e-01 0.109000 2.33e-02 1.22e-01
EUKARYOTIC TRANSLATION INITIATION 114 6.31e-04 6.14e-03 0.19400 -5.17e-02 -0.187000 3.40e-01 5.79e-04
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 1.30e-01 2.73e-01 0.19400 -1.06e-01 -0.162000 1.86e-01 4.33e-02
METHYLATION 11 4.49e-01 6.14e-01 0.19300 1.90e-01 0.038200 2.76e-01 8.26e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 68 1.01e-01 2.28e-01 0.19300 -1.35e-01 -0.138000 5.38e-02 4.95e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 30 3.03e-01 4.75e-01 0.19300 1.02e-01 0.163000 3.31e-01 1.22e-01
INTERFERON SIGNALING 161 3.33e-09 2.45e-07 0.19200 -1.88e-01 0.040300 3.89e-05 3.78e-01
EFFECTS OF PIP2 HYDROLYSIS 27 3.23e-02 1.04e-01 0.19200 -4.90e-02 0.186000 6.60e-01 9.46e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 1.59e-01 3.10e-01 0.19100 1.79e-01 0.067900 7.10e-02 4.93e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 4.58e-01 6.20e-01 0.19100 -1.65e-01 -0.096800 2.13e-01 4.65e-01
SENSORY PERCEPTION 158 2.87e-03 1.77e-02 0.19100 -1.08e-01 -0.158000 1.91e-02 6.31e-04
RHOBTB GTPASE CYCLE 35 3.09e-01 4.81e-01 0.19000 1.24e-01 0.145000 2.04e-01 1.39e-01
ANCHORING FIBRIL FORMATION 14 5.54e-01 7.02e-01 0.19000 -1.66e-01 -0.091500 2.81e-01 5.53e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 4.89e-01 6.49e-01 0.18900 1.58e-01 0.104000 2.32e-01 4.34e-01
RNA POLYMERASE I PROMOTER ESCAPE 50 1.13e-01 2.48e-01 0.18900 -8.73e-02 -0.168000 2.85e-01 3.98e-02
HEME SIGNALING 46 1.81e-02 6.65e-02 0.18900 -1.89e-01 -0.009410 2.65e-02 9.12e-01
SIGNALING BY GPCR 483 1.81e-07 7.89e-06 0.18900 1.25e-01 0.142000 2.72e-06 9.39e-08
RHO GTPASES ACTIVATE KTN1 11 5.23e-01 6.77e-01 0.18900 5.61e-02 0.181000 7.47e-01 3.00e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 3.44e-03 1.99e-02 0.18900 4.94e-02 0.183000 4.16e-01 2.62e-03
SIGNALING BY FGFR4 34 2.47e-01 4.19e-01 0.18900 1.65e-01 0.092900 9.67e-02 3.49e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 2.48e-01 4.19e-01 0.18900 -1.68e-01 -0.086600 1.00e-01 3.97e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 1.50e-01 2.99e-01 0.18800 1.32e-01 0.135000 8.06e-02 7.35e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 4.97e-01 6.56e-01 0.18800 -5.59e-02 -0.180000 7.37e-01 2.81e-01
PYRIMIDINE SALVAGE 10 7.18e-01 8.13e-01 0.18800 1.21e-01 0.144000 5.09e-01 4.29e-01
CRMPS IN SEMA3A SIGNALING 16 3.97e-01 5.62e-01 0.18800 -1.79e-01 -0.056300 2.15e-01 6.97e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 1.20e-02 4.90e-02 0.18800 -4.50e-02 0.182000 6.36e-01 5.52e-02
CYCLIN D ASSOCIATED EVENTS IN G1 45 2.14e-01 3.77e-01 0.18700 1.11e-01 0.150000 1.96e-01 8.09e-02
PHASE II CONJUGATION OF COMPOUNDS 64 1.30e-01 2.73e-01 0.18700 1.38e-01 0.126000 5.63e-02 8.10e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 5.59e-01 7.04e-01 0.18700 1.50e-01 0.111000 2.84e-01 4.28e-01
BIOLOGICAL OXIDATIONS 126 1.91e-02 6.89e-02 0.18600 1.35e-01 0.129000 9.01e-03 1.26e-02
CIRCADIAN CLOCK 68 7.77e-04 7.11e-03 0.18600 -2.42e-02 0.185000 7.30e-01 8.48e-03
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 5.57e-01 7.04e-01 0.18600 5.20e-02 0.178000 7.76e-01 3.29e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 2.92e-03 1.77e-02 0.18600 1.85e-01 -0.014600 1.39e-02 8.46e-01
RAC1 GTPASE CYCLE 177 4.44e-07 1.63e-05 0.18600 1.03e-02 0.185000 8.14e-01 2.13e-05
BASIGIN INTERACTIONS 22 2.61e-01 4.33e-01 0.18500 4.56e-02 0.179000 7.11e-01 1.46e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 4.34e-01 5.97e-01 0.18400 1.26e-01 0.134000 2.56e-01 2.27e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 1.17e-01 2.55e-01 0.18400 -1.50e-01 0.107000 3.14e-01 4.75e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.76e-03 2.83e-02 0.18400 1.83e-01 -0.014800 2.09e-02 8.52e-01
METABOLISM OF VITAMINS AND COFACTORS 151 9.38e-03 4.07e-02 0.18400 1.20e-01 0.139000 1.08e-02 3.28e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 4.64e-03 2.44e-02 0.18300 1.82e-01 0.017000 8.32e-03 8.06e-01
PEXOPHAGY 11 7.16e-01 8.12e-01 0.18300 1.26e-01 0.133000 4.71e-01 4.46e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 3.38e-01 5.10e-01 0.18300 -3.54e-02 0.179000 8.46e-01 3.26e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 4.16e-01 5.80e-01 0.18300 1.10e-01 0.146000 3.24e-01 1.89e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 2.34e-01 4.04e-01 0.18200 -4.16e-02 0.177000 7.95e-01 2.68e-01
ESTROGEN DEPENDENT GENE EXPRESSION 107 4.04e-02 1.22e-01 0.18200 -1.27e-01 -0.131000 2.38e-02 1.92e-02
G ALPHA 12 13 SIGNALLING EVENTS 75 5.61e-03 2.79e-02 0.18200 2.80e-02 0.180000 6.75e-01 7.06e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 5.91e-01 7.26e-01 0.18200 1.39e-01 0.117000 3.20e-01 4.03e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 1.36e-01 2.82e-01 0.18200 3.23e-02 0.179000 7.60e-01 8.97e-02
TRANSPORT OF SMALL MOLECULES 582 1.10e-08 6.79e-07 0.18100 1.07e-01 0.147000 1.08e-05 1.72e-09
RHO GTPASE CYCLE 422 1.06e-11 1.78e-09 0.18100 4.06e-02 0.177000 1.54e-01 5.27e-10
ASSEMBLY OF THE HIV VIRION 16 3.70e-01 5.36e-01 0.18100 1.77e-01 0.038700 2.21e-01 7.88e-01
DNA STRAND ELONGATION 32 1.28e-01 2.72e-01 0.18100 3.49e-02 0.178000 7.33e-01 8.23e-02
COLLAGEN DEGRADATION 52 7.00e-02 1.76e-01 0.18000 -5.73e-02 -0.171000 4.75e-01 3.33e-02
GROWTH HORMONE RECEPTOR SIGNALING 20 4.97e-01 6.56e-01 0.18000 1.53e-01 0.095400 2.37e-01 4.60e-01
INNATE IMMUNE SYSTEM 779 2.16e-10 2.54e-08 0.18000 1.35e-01 0.119000 1.65e-10 1.94e-08
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 7.05e-01 8.06e-01 0.17900 1.28e-01 0.125000 4.43e-01 4.52e-01
FRS MEDIATED FGFR3 SIGNALING 15 5.56e-01 7.02e-01 0.17900 1.59e-01 0.081800 2.86e-01 5.83e-01
CELL CELL COMMUNICATION 106 4.92e-03 2.53e-02 0.17900 5.73e-02 0.169000 3.08e-01 2.59e-03
L1CAM INTERACTIONS 108 2.99e-02 9.73e-02 0.17900 1.47e-01 0.101000 8.13e-03 6.93e-02
INFLUENZA INFECTION 145 1.47e-02 5.70e-02 0.17800 -1.17e-01 -0.134000 1.48e-02 5.32e-03
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 2.62e-01 4.33e-01 0.17800 1.69e-01 0.057600 1.30e-01 6.05e-01
GLUTATHIONE CONJUGATION 30 4.07e-01 5.71e-01 0.17800 1.39e-01 0.111000 1.89e-01 2.91e-01
PCP CE PATHWAY 89 6.59e-03 3.12e-02 0.17800 1.72e-01 0.044000 4.98e-03 4.73e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 185 3.65e-04 4.09e-03 0.17700 1.63e-01 0.070200 1.34e-04 1.00e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 2.71e-01 4.44e-01 0.17700 1.01e-01 0.146000 2.62e-01 1.06e-01
GLYCOLYSIS 67 1.51e-01 3.00e-01 0.17700 1.23e-01 0.126000 8.12e-02 7.36e-02
SARS COV INFECTIONS 140 1.67e-02 6.23e-02 0.17600 1.37e-01 0.110000 5.02e-03 2.42e-02
SIGNALING BY FGFR2 IN DISEASE 37 3.34e-01 5.06e-01 0.17600 -1.09e-01 -0.139000 2.53e-01 1.45e-01
PI 3K CASCADE FGFR1 16 2.08e-01 3.70e-01 0.17600 -1.74e-01 0.029500 2.29e-01 8.38e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 3.95e-03 2.18e-02 0.17600 1.71e-01 -0.041200 3.13e-02 6.04e-01
SIGNALING BY MET 74 1.27e-02 5.10e-02 0.17600 3.64e-02 0.172000 5.89e-01 1.06e-02
SIGNALING BY THE B CELL RECEPTOR BCR 103 2.16e-02 7.56e-02 0.17600 1.56e-01 0.081100 6.34e-03 1.55e-01
S PHASE 154 1.40e-02 5.53e-02 0.17500 1.27e-01 0.121000 6.65e-03 9.56e-03
HIV INFECTION 221 2.30e-03 1.51e-02 0.17500 1.28e-01 0.119000 1.06e-03 2.36e-03
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 2.00e-01 3.62e-01 0.17500 -1.60e-02 -0.174000 8.94e-01 1.49e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 2.32e-02 8.05e-02 0.17400 -7.54e-03 0.174000 9.30e-01 4.32e-02
SELENOAMINO ACID METABOLISM 108 8.95e-03 3.91e-02 0.17400 -6.41e-02 -0.162000 2.50e-01 3.62e-03
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 2.92e-01 4.65e-01 0.17400 1.67e-01 0.048200 1.57e-01 6.83e-01
FGFR1 LIGAND BINDING AND ACTIVATION 10 7.31e-01 8.23e-01 0.17400 -1.45e-01 -0.096400 4.29e-01 5.98e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 2.05e-11 3.02e-09 0.17400 7.06e-02 0.159000 2.61e-03 1.31e-11
DNA REPLICATION PRE INITIATION 80 5.11e-02 1.41e-01 0.17400 1.55e-01 0.078300 1.66e-02 2.26e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 2.63e-01 4.34e-01 0.17300 -5.48e-02 -0.165000 6.16e-01 1.32e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 47 4.90e-02 1.37e-01 0.17300 -2.41e-02 -0.172000 7.75e-01 4.17e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 6.52e-01 7.69e-01 0.17300 1.36e-01 0.108000 3.63e-01 4.70e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 2.25e-01 3.91e-01 0.17300 -1.56e-01 -0.074900 9.20e-02 4.18e-01
G1 S DNA DAMAGE CHECKPOINTS 65 1.96e-03 1.37e-02 0.17300 1.70e-01 -0.031600 1.78e-02 6.60e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.38e-02 5.49e-02 0.17200 -1.93e-02 -0.171000 7.88e-01 1.71e-02
ADAPTIVE IMMUNE SYSTEM 608 9.46e-08 4.64e-06 0.17200 1.31e-01 0.112000 3.83e-08 2.79e-06
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 4.70e-01 6.30e-01 0.17100 1.65e-01 0.046500 2.69e-01 7.55e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 6.09e-01 7.40e-01 0.17100 1.61e-01 0.056700 3.55e-01 7.45e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 2.21e-01 3.87e-01 0.17000 1.49e-01 0.082700 8.47e-02 3.37e-01
TIE2 SIGNALING 17 6.39e-01 7.58e-01 0.17000 1.25e-01 0.116000 3.73e-01 4.10e-01
ONCOGENIC MAPK SIGNALING 77 9.92e-02 2.25e-01 0.17000 9.38e-02 0.142000 1.55e-01 3.16e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.67e-01 3.19e-01 0.17000 -1.70e-01 0.004690 1.59e-01 9.69e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 4.63e-02 1.33e-01 0.17000 1.64e-01 -0.043000 1.13e-01 6.78e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 106 5.02e-02 1.39e-01 0.17000 -1.37e-01 -0.100000 1.50e-02 7.46e-02
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 7.05e-01 8.06e-01 0.16900 -1.31e-01 -0.108000 4.15e-01 5.02e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 1.71e-01 3.23e-01 0.16900 1.15e-02 0.169000 9.19e-01 1.36e-01
REGULATION OF FZD BY UBIQUITINATION 19 6.10e-01 7.40e-01 0.16900 1.23e-01 0.116000 3.55e-01 3.80e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 3.43e-01 5.12e-01 0.16900 -9.58e-02 -0.139000 3.13e-01 1.44e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 2.09e-01 3.70e-01 0.16900 1.34e-01 -0.102000 4.01e-01 5.25e-01
DEATH RECEPTOR SIGNALLING 132 2.91e-03 1.77e-02 0.16900 5.44e-02 0.160000 2.81e-01 1.57e-03
MITOCHONDRIAL TRANSLATION 93 7.33e-05 1.14e-03 0.16800 5.32e-02 -0.160000 3.76e-01 7.76e-03
TRANSCRIPTIONAL REGULATION BY MECP2 59 2.50e-02 8.49e-02 0.16800 -1.67e-01 -0.019300 2.66e-02 7.98e-01
HEMOSTASIS 478 5.22e-06 1.43e-04 0.16800 1.09e-01 0.128000 4.72e-05 1.88e-06
AQUAPORIN MEDIATED TRANSPORT 41 2.59e-01 4.32e-01 0.16800 1.47e-01 0.080600 1.03e-01 3.72e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 6.25e-02 1.61e-01 0.16700 -5.32e-02 -0.158000 4.65e-01 2.97e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 4.73e-01 6.32e-01 0.16700 1.50e-01 0.071900 2.33e-01 5.68e-01
LONG TERM POTENTIATION 23 4.07e-01 5.71e-01 0.16700 6.34e-02 0.154000 5.99e-01 2.01e-01
PI 3K CASCADE FGFR3 13 2.53e-01 4.27e-01 0.16600 -6.38e-02 0.154000 6.90e-01 3.37e-01
MYOGENESIS 25 6.35e-02 1.64e-01 0.16600 -7.57e-02 0.148000 5.12e-01 2.00e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 3.40e-01 5.12e-01 0.16600 4.82e-02 -0.159000 7.82e-01 3.61e-01
TRANSLESION SYNTHESIS BY POLK 17 6.50e-01 7.68e-01 0.16600 -1.24e-01 -0.110000 3.76e-01 4.32e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 1.74e-01 3.27e-01 0.16600 8.94e-02 0.140000 2.31e-01 6.14e-02
NUCLEAR SIGNALING BY ERBB4 31 4.53e-01 6.20e-01 0.16600 1.27e-01 0.107000 2.23e-01 3.04e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 182 2.37e-03 1.53e-02 0.16600 -7.57e-02 -0.147000 7.85e-02 6.23e-04
INTERLEUKIN 12 FAMILY SIGNALING 43 7.93e-02 1.93e-01 0.16500 1.64e-01 0.022100 6.29e-02 8.02e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 162 2.49e-05 4.80e-04 0.16500 -9.50e-03 -0.165000 8.35e-01 2.90e-04
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 2.76e-01 4.50e-01 0.16500 1.18e-01 -0.115000 4.99e-01 5.07e-01
INTERLEUKIN 12 SIGNALING 37 1.12e-01 2.46e-01 0.16400 1.63e-01 0.020200 8.59e-02 8.31e-01
DISEASES OF GLYCOSYLATION 123 2.97e-02 9.68e-02 0.16400 1.39e-01 0.088100 8.01e-03 9.16e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 1.62e-02 6.07e-02 0.16400 1.60e-01 0.036200 1.23e-02 5.71e-01
TOLL LIKE RECEPTOR CASCADES 138 1.48e-02 5.70e-02 0.16400 8.08e-02 0.142000 1.01e-01 3.91e-03
RHO GTPASE EFFECTORS 251 2.46e-03 1.56e-02 0.16300 1.20e-01 0.110000 1.07e-03 2.67e-03
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 5.59e-01 7.04e-01 0.16300 1.42e-01 0.079700 2.84e-01 5.47e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 7.54e-01 8.38e-01 0.16300 9.84e-02 0.130000 5.72e-01 4.57e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 5.16e-01 6.72e-01 0.16300 1.58e-01 0.040400 3.08e-01 7.93e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 3.46e-01 5.15e-01 0.16200 -1.03e-01 -0.125000 2.41e-01 1.55e-01
TCR SIGNALING 101 1.49e-02 5.74e-02 0.16200 1.54e-01 0.050800 7.60e-03 3.78e-01
C TYPE LECTIN RECEPTORS CLRS 112 1.38e-02 5.49e-02 0.16200 1.51e-01 0.058000 5.78e-03 2.89e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 93 5.08e-03 2.59e-02 0.16200 2.04e-02 0.160000 7.35e-01 7.53e-03
ORC1 REMOVAL FROM CHROMATIN 67 2.38e-02 8.18e-02 0.16200 1.60e-01 0.022100 2.36e-02 7.55e-01
MITOCHONDRIAL PROTEIN IMPORT 63 3.73e-02 1.15e-01 0.16100 1.59e-01 0.028800 2.93e-02 6.93e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 5.01e-01 6.58e-01 0.16100 1.61e-01 -0.002690 3.78e-01 9.88e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 6.27e-01 7.52e-01 0.16000 -1.39e-01 -0.080200 3.36e-01 5.78e-01
MITOTIC PROMETAPHASE 177 7.80e-03 3.51e-02 0.16000 8.48e-02 0.136000 5.18e-02 1.85e-03
ENOS ACTIVATION 11 5.77e-01 7.20e-01 0.16000 1.57e-01 0.031200 3.68e-01 8.58e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 1.31e-02 5.28e-02 0.16000 1.57e-01 0.029700 1.20e-02 6.34e-01
CDC42 GTPASE CYCLE 153 8.88e-06 2.13e-04 0.15900 -2.02e-02 0.158000 6.66e-01 7.77e-04
MET PROMOTES CELL MOTILITY 39 2.85e-02 9.40e-02 0.15900 -5.01e-02 0.151000 5.88e-01 1.04e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 2.36e-03 1.53e-02 0.15900 -3.34e-02 0.155000 6.21e-01 2.21e-02
INTERLEUKIN 2 FAMILY SIGNALING 32 3.57e-02 1.12e-01 0.15900 -8.56e-02 0.133000 4.02e-01 1.92e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 5.83e-01 7.21e-01 0.15800 8.39e-02 0.134000 5.16e-01 2.99e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 3.40e-01 5.12e-01 0.15800 9.03e-02 0.129000 3.06e-01 1.43e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 1.61e-03 1.23e-02 0.15700 1.18e-01 0.104000 5.90e-04 2.52e-03
SIGNALING BY PTK6 50 3.21e-01 4.93e-01 0.15700 1.04e-01 0.118000 2.02e-01 1.50e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 2.86e-01 4.59e-01 0.15700 1.42e-01 -0.066300 3.74e-01 6.79e-01
DEGRADATION OF AXIN 53 6.73e-02 1.70e-01 0.15700 1.55e-01 0.024800 5.12e-02 7.55e-01
NICOTINAMIDE SALVAGING 14 2.35e-01 4.05e-01 0.15700 -9.04e-02 0.128000 5.58e-01 4.07e-01
DISEASES OF METABOLISM 197 1.22e-02 4.97e-02 0.15600 1.19e-01 0.101000 4.16e-03 1.42e-02
INTERLEUKIN 1 SIGNALING 96 7.85e-02 1.92e-01 0.15600 1.33e-01 0.081200 2.43e-02 1.69e-01
PHASE 2 PLATEAU PHASE 10 6.10e-01 7.40e-01 0.15600 -1.54e-01 -0.026700 4.01e-01 8.84e-01
CELL CELL JUNCTION ORGANIZATION 48 3.24e-01 4.97e-01 0.15500 9.28e-02 0.124000 2.66e-01 1.37e-01
DEGRADATION OF DVL 55 1.97e-02 7.01e-02 0.15500 1.54e-01 -0.017100 4.81e-02 8.27e-01
REGULATION OF IFNA SIGNALING 12 2.93e-01 4.65e-01 0.15500 -1.21e-01 0.096600 4.67e-01 5.63e-01
SIGNALING BY KIT IN DISEASE 20 3.84e-01 5.45e-01 0.15500 2.83e-02 0.152000 8.27e-01 2.38e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 4.69e-01 6.30e-01 0.15500 1.18e-01 0.100000 2.34e-01 3.12e-01
RNA POLYMERASE III TRANSCRIPTION 41 2.77e-01 4.50e-01 0.15500 -6.50e-02 -0.140000 4.72e-01 1.20e-01
INITIAL TRIGGERING OF COMPLEMENT 12 7.68e-01 8.46e-01 0.15500 1.03e-01 0.116000 5.38e-01 4.88e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 6.72e-04 6.43e-03 0.15400 -8.92e-02 0.126000 1.88e-01 6.27e-02
M PHASE 343 6.24e-04 6.12e-03 0.15400 1.16e-01 0.102000 2.30e-04 1.24e-03
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 7.69e-01 8.46e-01 0.15300 8.75e-02 0.126000 6.16e-01 4.69e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 7.06e-01 8.06e-01 0.15300 -7.65e-02 -0.133000 6.33e-01 4.06e-01
CLEC7A DECTIN 1 SIGNALING 94 2.15e-02 7.56e-02 0.15300 1.48e-01 0.040200 1.32e-02 5.00e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 5.75e-01 7.18e-01 0.15300 9.67e-02 0.119000 4.03e-01 3.04e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 68 2.02e-01 3.63e-01 0.15300 -8.81e-02 -0.125000 2.09e-01 7.41e-02
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 7.25e-01 8.19e-01 0.15300 6.06e-02 0.141000 7.40e-01 4.41e-01
THE NLRP3 INFLAMMASOME 15 3.47e-01 5.15e-01 0.15300 -1.52e-01 0.018800 3.09e-01 9.00e-01
RRNA PROCESSING 194 1.73e-03 1.26e-02 0.15300 -5.76e-02 -0.141000 1.67e-01 6.87e-04
INTRINSIC PATHWAY FOR APOPTOSIS 52 1.63e-01 3.15e-01 0.15300 1.43e-01 0.053100 7.41e-02 5.08e-01
ECM PROTEOGLYCANS 68 2.33e-01 4.03e-01 0.15300 -1.00e-01 -0.115000 1.52e-01 1.01e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 62 2.41e-01 4.11e-01 0.15200 1.23e-01 0.089600 9.31e-02 2.23e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 5.69e-01 7.13e-01 0.15200 9.80e-02 0.117000 3.87e-01 3.03e-01
RHO GTPASES ACTIVATE PKNS 50 3.86e-02 1.18e-01 0.15200 1.00e-02 -0.151000 9.02e-01 6.39e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.43e-01 5.13e-01 0.15200 1.03e-01 0.111000 2.02e-01 1.69e-01
MET ACTIVATES PTK2 SIGNALING 29 1.22e-01 2.62e-01 0.15200 -1.50e-01 0.025000 1.63e-01 8.16e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 44 3.20e-01 4.92e-01 0.15200 7.65e-02 0.131000 3.80e-01 1.33e-01
PURINE CATABOLISM 16 6.12e-01 7.41e-01 0.15100 1.38e-01 0.061900 3.38e-01 6.68e-01
DNA REPLICATION 122 3.68e-02 1.14e-01 0.15100 1.33e-01 0.071800 1.10e-02 1.71e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 3.16e-01 4.87e-01 0.15100 3.70e-03 0.151000 9.77e-01 2.42e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 72 7.48e-03 3.43e-02 0.15100 -1.73e-02 0.150000 7.99e-01 2.79e-02
TRANSCRIPTIONAL REGULATION BY E2F6 34 4.56e-01 6.20e-01 0.15100 8.53e-02 0.124000 3.90e-01 2.10e-01
REPRODUCTION 80 1.72e-01 3.26e-01 0.15000 -9.05e-02 -0.120000 1.62e-01 6.31e-02
INTERLEUKIN 15 SIGNALING 12 5.79e-01 7.21e-01 0.15000 -1.48e-01 -0.026800 3.75e-01 8.72e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 1.57e-01 3.07e-01 0.15000 1.45e-01 -0.037700 2.19e-01 7.49e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 7.07e-01 8.06e-01 0.15000 7.69e-02 0.128000 6.18e-01 4.06e-01
ADHERENS JUNCTIONS INTERACTIONS 30 5.01e-01 6.58e-01 0.14900 8.30e-02 0.124000 4.32e-01 2.40e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 314 7.71e-05 1.16e-03 0.14800 1.37e-01 0.057000 3.22e-05 8.29e-02
FRS MEDIATED FGFR4 SIGNALING 15 3.17e-01 4.88e-01 0.14800 1.42e-01 -0.040900 3.41e-01 7.84e-01
CELL JUNCTION ORGANIZATION 73 1.25e-01 2.67e-01 0.14700 6.16e-02 0.134000 3.63e-01 4.79e-02
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 3.62e-01 5.28e-01 0.14700 -9.36e-02 0.113000 5.91e-01 5.15e-01
CELLULAR RESPONSE TO HYPOXIA 72 1.58e-02 5.93e-02 0.14700 1.46e-01 -0.003770 3.17e-02 9.56e-01
CELL CYCLE MITOTIC 478 1.10e-04 1.57e-03 0.14600 1.08e-01 0.098700 5.42e-05 2.26e-04
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 3.67e-01 5.33e-01 0.14600 -1.39e-01 0.045900 3.87e-01 7.75e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 4.60e-01 6.20e-01 0.14600 1.33e-01 0.058300 2.30e-01 6.00e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.05e-01 8.72e-01 0.14600 8.22e-02 0.120000 6.53e-01 5.11e-01
LAGGING STRAND SYNTHESIS 20 2.56e-01 4.29e-01 0.14500 -2.69e-02 0.143000 8.35e-01 2.68e-01
SIGNALING BY ACTIVIN 11 6.80e-01 7.88e-01 0.14500 4.22e-02 0.139000 8.09e-01 4.25e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 7.55e-01 8.39e-01 0.14500 1.29e-01 0.067300 4.60e-01 6.99e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 5.23e-01 6.77e-01 0.14500 1.15e-01 0.087300 2.59e-01 3.93e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 346 1.60e-03 1.23e-02 0.14400 1.04e-01 0.100000 8.80e-04 1.42e-03
SIGNALING BY ERBB4 57 2.67e-01 4.39e-01 0.14400 1.24e-01 0.073600 1.05e-01 3.37e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 7.95e-02 1.93e-01 0.14400 1.41e-01 0.030300 5.12e-02 6.75e-01
PHASE 0 RAPID DEPOLARISATION 28 5.90e-01 7.25e-01 0.14400 -1.00e-01 -0.104000 3.59e-01 3.42e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 3.61e-01 5.28e-01 0.14400 1.25e-01 0.071400 1.56e-01 4.18e-01
INWARDLY RECTIFYING K CHANNELS 32 5.38e-01 6.90e-01 0.14400 1.11e-01 0.091400 2.78e-01 3.71e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 6.75e-01 7.86e-01 0.14300 -1.13e-01 -0.088800 3.83e-01 4.92e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 5.30e-01 6.83e-01 0.14300 -2.06e-02 0.142000 9.10e-01 4.38e-01
BASE EXCISION REPAIR 60 1.90e-01 3.53e-01 0.14300 -5.76e-02 -0.131000 4.41e-01 7.93e-02
NICOTINATE METABOLISM 23 4.70e-01 6.30e-01 0.14300 4.44e-02 0.136000 7.12e-01 2.59e-01
SNRNP ASSEMBLY 51 1.03e-01 2.31e-01 0.14300 1.81e-02 0.142000 8.23e-01 7.96e-02
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 284 4.44e-03 2.36e-02 0.14300 8.96e-02 0.111000 9.50e-03 1.25e-03
RAS PROCESSING 24 4.87e-01 6.47e-01 0.14300 1.33e-01 0.051500 2.58e-01 6.63e-01
ZINC TRANSPORTERS 16 5.90e-01 7.25e-01 0.14300 1.36e-01 0.043800 3.46e-01 7.62e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 462 1.23e-04 1.69e-03 0.14300 8.46e-02 0.115000 1.87e-03 2.49e-05
DNA DAMAGE RECOGNITION IN GG NER 38 4.45e-01 6.09e-01 0.14300 1.19e-01 0.077900 2.03e-01 4.06e-01
SIGNALING BY EGFR IN CANCER 22 2.60e-01 4.33e-01 0.14200 1.74e-02 -0.141000 8.88e-01 2.51e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 6.16e-01 7.42e-01 0.14200 -7.85e-02 -0.119000 5.15e-01 3.25e-01
PEPTIDE LIGAND BINDING RECEPTORS 110 5.45e-03 2.73e-02 0.14200 1.42e-01 0.010000 1.04e-02 8.56e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 3.74e-01 5.39e-01 0.14200 -1.37e-01 0.038300 3.76e-01 8.04e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 5.09e-02 1.41e-01 0.14200 1.42e-01 0.003620 5.99e-02 9.62e-01
NOD1 2 SIGNALING PATHWAY 35 2.14e-01 3.78e-01 0.14100 1.68e-02 0.140000 8.64e-01 1.51e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 3.14e-01 4.84e-01 0.14100 -1.28e-01 0.059000 3.91e-01 6.92e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 40 3.01e-01 4.74e-01 0.14100 -4.79e-02 -0.132000 6.00e-01 1.48e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 3.31e-01 5.03e-01 0.14000 3.89e-02 0.135000 6.99e-01 1.80e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 94 6.17e-02 1.60e-01 0.14000 1.32e-01 0.047600 2.75e-02 4.26e-01
CHAPERONE MEDIATED AUTOPHAGY 20 3.51e-01 5.18e-01 0.14000 1.40e-01 -0.002840 2.79e-01 9.82e-01
POLO LIKE KINASE MEDIATED EVENTS 14 4.68e-01 6.30e-01 0.14000 1.40e-01 -0.006720 3.65e-01 9.65e-01
CELLULAR RESPONSE TO STARVATION 146 3.62e-03 2.07e-02 0.14000 -2.58e-02 -0.137000 5.91e-01 4.24e-03
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 94 7.73e-02 1.91e-01 0.14000 5.33e-02 0.129000 3.72e-01 3.09e-02
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 5.81e-01 7.21e-01 0.13900 -1.22e-01 -0.067500 3.01e-01 5.67e-01
PLASMA LIPOPROTEIN REMODELING 14 4.92e-01 6.52e-01 0.13900 -9.00e-05 0.139000 1.00e+00 3.67e-01
SIGNALING BY FGFR1 IN DISEASE 33 2.78e-01 4.50e-01 0.13900 2.42e-02 0.136000 8.10e-01 1.75e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 6.01e-01 7.34e-01 0.13900 -1.38e-01 -0.007900 4.27e-01 9.64e-01
O LINKED GLYCOSYLATION 85 1.89e-01 3.51e-01 0.13900 7.80e-02 0.115000 2.14e-01 6.81e-02
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 6.34e-01 7.56e-01 0.13900 1.26e-01 0.057700 3.55e-01 6.72e-01
OTHER SEMAPHORIN INTERACTIONS 19 5.76e-01 7.18e-01 0.13800 -1.30e-01 -0.047100 3.26e-01 7.22e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 6.40e-01 7.59e-01 0.13700 1.33e-01 0.032600 4.05e-01 8.39e-01
MICRORNA MIRNA BIOGENESIS 24 6.14e-01 7.41e-01 0.13700 -7.20e-02 -0.116000 5.41e-01 3.23e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 7.07e-01 8.06e-01 0.13700 1.33e-01 0.031300 4.66e-01 8.64e-01
SHC MEDIATED CASCADE FGFR3 13 4.57e-01 6.20e-01 0.13700 1.35e-01 -0.025000 4.01e-01 8.76e-01
HOMOLOGY DIRECTED REPAIR 111 4.42e-02 1.29e-01 0.13700 -1.28e-01 -0.046900 1.95e-02 3.93e-01
INTERLEUKIN 1 FAMILY SIGNALING 123 1.07e-01 2.38e-01 0.13700 1.10e-01 0.081700 3.58e-02 1.18e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.46e-01 2.95e-01 0.13700 6.29e-02 0.121000 3.16e-01 5.33e-02
GLUCAGON TYPE LIGAND RECEPTORS 26 1.84e-01 3.44e-01 0.13600 3.79e-02 -0.131000 7.38e-01 2.48e-01
RHOH GTPASE CYCLE 37 5.35e-01 6.88e-01 0.13600 1.02e-01 0.090000 2.85e-01 3.44e-01
METABOLISM OF FOLATE AND PTERINES 15 7.38e-01 8.28e-01 0.13500 1.16e-01 0.069600 4.37e-01 6.41e-01
MITOTIC PROPHASE 97 1.99e-01 3.62e-01 0.13500 9.10e-02 0.099900 1.21e-01 8.92e-02
PLASMA LIPOPROTEIN ASSEMBLY 12 7.58e-01 8.41e-01 0.13500 5.90e-02 0.121000 7.24e-01 4.67e-01
CROSSLINKING OF COLLAGEN FIBRILS 15 6.26e-01 7.52e-01 0.13400 -3.58e-02 -0.129000 8.10e-01 3.85e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.82e-01 3.40e-01 0.13400 -1.13e-01 0.071500 3.48e-01 5.53e-01
ION TRANSPORT BY P TYPE ATPASES 50 9.69e-02 2.21e-01 0.13300 -1.09e-03 0.133000 9.89e-01 1.03e-01
CRISTAE FORMATION 31 1.09e-01 2.41e-01 0.13300 6.37e-02 -0.117000 5.39e-01 2.60e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 32 1.61e-01 3.12e-01 0.13300 2.49e-02 -0.131000 8.08e-01 2.01e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 9.11e-02 2.13e-01 0.13200 1.32e-01 0.015600 7.34e-02 8.31e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 77 2.93e-01 4.65e-01 0.13200 8.95e-02 0.097600 1.75e-01 1.39e-01
RUNX3 REGULATES NOTCH SIGNALING 13 3.80e-01 5.43e-01 0.13200 -1.03e-01 0.083100 5.22e-01 6.04e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 3.84e-01 5.45e-01 0.13200 -2.51e-02 -0.129000 8.18e-01 2.36e-01
G PROTEIN ACTIVATION 23 1.81e-01 3.39e-01 0.13200 8.61e-02 -0.099700 4.75e-01 4.08e-01
HCMV INFECTION 106 1.82e-01 3.40e-01 0.13100 8.37e-02 0.101000 1.37e-01 7.20e-02
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 5.29e-01 6.82e-01 0.13100 2.98e-02 0.128000 8.17e-01 3.23e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 3.48e-01 5.15e-01 0.13100 -1.59e-02 -0.130000 8.85e-01 2.34e-01
PI3K AKT SIGNALING IN CANCER 91 1.08e-01 2.40e-01 0.13100 4.88e-02 0.121000 4.22e-01 4.53e-02
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 4.11e-01 5.73e-01 0.13100 1.27e-01 0.032100 2.38e-01 7.65e-01
PROGRAMMED CELL DEATH 186 6.81e-03 3.17e-02 0.13100 1.24e-01 0.041400 3.58e-03 3.31e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.29e-01 7.52e-01 0.13100 1.18e-01 0.055900 3.49e-01 6.57e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 6.50e-01 7.68e-01 0.13000 9.15e-02 0.092800 4.02e-01 3.95e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 5.85e-01 7.22e-01 0.13000 1.20e-01 0.051300 3.20e-01 6.70e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 4.34e-01 5.97e-01 0.13000 6.99e-02 -0.109000 6.75e-01 5.13e-01
GENE SILENCING BY RNA 85 2.03e-01 3.64e-01 0.12900 -1.12e-01 -0.065100 7.51e-02 3.00e-01
DAP12 INTERACTIONS 30 3.46e-01 5.15e-01 0.12900 -1.28e-01 -0.018700 2.26e-01 8.59e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.62e-01 4.33e-01 0.12900 -1.28e-01 -0.018800 1.73e-01 8.41e-01
RNA POLYMERASE I TRANSCRIPTION 70 2.82e-01 4.56e-01 0.12900 -6.76e-02 -0.110000 3.28e-01 1.12e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 5.95e-01 7.28e-01 0.12900 -1.09e-01 -0.068000 3.08e-01 5.26e-01
VIRAL MESSENGER RNA SYNTHESIS 42 5.19e-02 1.43e-01 0.12800 -9.88e-02 0.082100 2.68e-01 3.57e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 5.01e-01 6.58e-01 0.12800 -1.51e-02 -0.127000 9.09e-01 3.36e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 4.00e-01 5.64e-01 0.12800 7.86e-02 0.101000 3.00e-01 1.82e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.30e-01 7.52e-01 0.12800 1.14e-01 0.058800 3.44e-01 6.25e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 4.72e-01 6.32e-01 0.12800 -1.67e-02 0.127000 9.11e-01 3.94e-01
SIGNALING BY INSULIN RECEPTOR 65 3.81e-01 5.43e-01 0.12800 9.14e-02 0.089800 2.03e-01 2.11e-01
RHO GTPASES ACTIVATE CIT 18 7.44e-01 8.33e-01 0.12800 -7.35e-02 -0.105000 5.89e-01 4.42e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 2.74e-01 4.49e-01 0.12800 2.58e-02 0.125000 7.75e-01 1.66e-01
SODIUM CALCIUM EXCHANGERS 10 5.22e-01 6.76e-01 0.12800 -5.86e-02 0.113000 7.48e-01 5.35e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 8.01e-01 8.69e-01 0.12800 -1.10e-01 -0.063800 5.08e-01 7.02e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 6.92e-01 7.98e-01 0.12700 -8.74e-02 -0.092500 4.49e-01 4.24e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 3.67e-03 2.09e-02 0.12700 7.67e-02 0.101000 1.16e-02 9.19e-04
CHROMATIN MODIFYING ENZYMES 222 2.91e-03 1.77e-02 0.12600 -1.21e-01 -0.035900 1.96e-03 3.58e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.52e-01 5.19e-01 0.12500 -4.28e-02 0.118000 7.54e-01 3.87e-01
APOPTOSIS 164 1.16e-02 4.80e-02 0.12500 1.21e-01 0.032900 7.59e-03 4.67e-01
DISEASES OF IMMUNE SYSTEM 25 4.44e-01 6.09e-01 0.12500 -1.24e-01 -0.020000 2.85e-01 8.63e-01
JOSEPHIN DOMAIN DUBS 11 6.76e-01 7.86e-01 0.12500 1.24e-01 0.012300 4.75e-01 9.44e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 5.36e-01 6.88e-01 0.12400 1.18e-01 -0.040900 5.00e-01 8.14e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 284 4.08e-03 2.23e-02 0.12400 1.12e-01 0.054000 1.21e-03 1.18e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 6.10e-01 7.40e-01 0.12400 -1.03e-01 -0.068300 3.20e-01 5.11e-01
UB SPECIFIC PROCESSING PROTEASES 167 9.42e-02 2.19e-01 0.12400 9.49e-02 0.079000 3.45e-02 7.83e-02
P38MAPK EVENTS 13 8.24e-01 8.83e-01 0.12300 7.31e-02 0.099100 6.48e-01 5.36e-01
COLLAGEN FORMATION 79 2.23e-01 3.89e-01 0.12300 -5.43e-02 -0.110000 4.04e-01 9.01e-02
HS GAG DEGRADATION 20 4.60e-01 6.20e-01 0.12300 1.23e-01 0.000556 3.43e-01 9.97e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 18 4.07e-01 5.71e-01 0.12200 2.68e-02 -0.120000 8.44e-01 3.80e-01
TNFR2 NON CANONICAL NF KB PATHWAY 79 1.66e-01 3.19e-01 0.12200 1.15e-01 0.040700 7.75e-02 5.31e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 68 4.68e-02 1.34e-01 0.12200 1.21e-01 -0.016100 8.57e-02 8.18e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 4.56e-01 6.20e-01 0.12100 2.46e-03 0.121000 9.84e-01 3.35e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 7.53e-01 8.38e-01 0.12100 9.17e-02 0.078300 4.67e-01 5.34e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 3.06e-01 4.77e-01 0.12100 8.07e-02 -0.089500 5.42e-01 4.99e-01
SIGNALING BY FGFR1 44 5.60e-01 7.04e-01 0.12000 8.86e-02 0.081100 3.09e-01 3.52e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 3.76e-01 5.40e-01 0.12000 9.59e-02 -0.072300 5.07e-01 6.16e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 6.09e-01 7.40e-01 0.12000 5.48e-02 0.107000 6.16e-01 3.27e-01
NEGATIVE REGULATION OF FLT3 14 4.20e-01 5.83e-01 0.12000 -8.84e-02 0.081200 5.67e-01 5.99e-01
PREGNENOLONE BIOSYNTHESIS 12 7.28e-01 8.20e-01 0.12000 -2.73e-02 -0.116000 8.70e-01 4.85e-01
PLATELET AGGREGATION PLUG FORMATION 32 6.13e-01 7.41e-01 0.12000 6.38e-02 0.101000 5.32e-01 3.23e-01
OTHER INTERLEUKIN SIGNALING 20 4.92e-01 6.52e-01 0.12000 1.19e-01 0.004260 3.55e-01 9.74e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 118 2.03e-01 3.64e-01 0.11900 9.37e-02 0.073900 7.88e-02 1.66e-01
EARLY PHASE OF HIV LIFE CYCLE 13 5.07e-01 6.64e-01 0.11800 4.16e-02 -0.111000 7.95e-01 4.89e-01
INTERLEUKIN 7 SIGNALING 19 7.52e-01 8.37e-01 0.11800 -1.00e-01 -0.063100 4.50e-01 6.34e-01
TRP CHANNELS 20 3.06e-01 4.77e-01 0.11800 -7.20e-02 0.093700 5.77e-01 4.68e-01
MITOTIC G2 G2 M PHASES 184 1.19e-02 4.88e-02 0.11800 1.14e-01 0.031200 7.74e-03 4.66e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 4.31e-01 5.96e-01 0.11800 9.85e-02 0.065100 1.95e-01 3.92e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.53e-01 9.04e-01 0.11700 9.27e-02 0.072100 5.78e-01 6.65e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 5.50e-01 7.02e-01 0.11700 5.11e-02 -0.106000 7.69e-01 5.44e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.98e-01 6.57e-01 0.11700 -6.90e-02 0.094800 6.79e-01 5.70e-01
TRANSLATION 286 8.21e-08 4.54e-06 0.11700 9.25e-02 -0.071200 7.19e-03 3.86e-02
SHC MEDIATED CASCADE FGFR1 16 6.14e-01 7.41e-01 0.11600 -1.24e-02 -0.116000 9.31e-01 4.23e-01
TELOMERE EXTENSION BY TELOMERASE 22 4.36e-01 5.99e-01 0.11600 1.16e-01 -0.006200 3.45e-01 9.60e-01
SIGNALING BY INTERLEUKINS 349 1.50e-02 5.76e-02 0.11600 8.22e-02 0.082200 8.43e-03 8.48e-03
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 5.82e-01 7.21e-01 0.11600 -2.27e-03 0.116000 9.88e-01 4.36e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 7.01e-01 8.04e-01 0.11600 -3.45e-02 -0.111000 8.11e-01 4.42e-01
DNA DOUBLE STRAND BREAK REPAIR 140 2.49e-02 8.49e-02 0.11600 -1.14e-01 -0.022100 2.00e-02 6.51e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 8.63e-01 9.12e-01 0.11600 -5.99e-02 -0.098800 7.43e-01 5.88e-01
ION HOMEOSTASIS 50 1.43e-01 2.91e-01 0.11500 -1.11e-02 0.115000 8.92e-01 1.60e-01
ERBB2 REGULATES CELL MOTILITY 14 7.74e-01 8.51e-01 0.11500 4.48e-02 0.106000 7.71e-01 4.93e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 5.25e-01 6.78e-01 0.11500 8.70e-02 0.074900 2.74e-01 3.46e-01
CELL CYCLE CHECKPOINTS 245 4.97e-02 1.38e-01 0.11500 8.92e-02 0.072100 1.64e-02 5.24e-02
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 5.03e-01 6.60e-01 0.11400 4.27e-02 -0.105000 7.82e-01 4.95e-01
MAPK6 MAPK4 SIGNALING 83 4.50e-02 1.31e-01 0.11300 1.12e-01 -0.011100 7.68e-02 8.61e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 7.99e-01 8.68e-01 0.11300 3.48e-02 0.107000 8.41e-01 5.38e-01
LEISHMANIA INFECTION 198 8.25e-02 1.99e-01 0.11200 6.44e-02 0.092000 1.19e-01 2.58e-02
PTEN REGULATION 133 6.69e-02 1.70e-01 0.11200 1.07e-01 0.033900 3.34e-02 5.00e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 86 1.93e-02 6.92e-02 0.11200 3.74e-02 -0.105000 5.49e-01 9.10e-02
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 92 2.54e-01 4.27e-01 0.11100 5.11e-02 0.098400 3.98e-01 1.03e-01
ONCOGENE INDUCED SENESCENCE 32 6.93e-01 7.98e-01 0.11100 7.09e-02 0.085100 4.88e-01 4.05e-01
TRAFFICKING OF AMPA RECEPTORS 31 6.96e-01 8.00e-01 0.11100 8.72e-02 0.067900 4.01e-01 5.13e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 5.54e-01 7.02e-01 0.11000 -1.10e-01 -0.013300 3.73e-01 9.14e-01
DISEASES OF PROGRAMMED CELL DEATH 57 1.59e-01 3.10e-01 0.11000 1.51e-03 -0.110000 9.84e-01 1.50e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 4.34e-01 5.97e-01 0.11000 -1.07e-01 0.027900 4.09e-01 8.29e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 7.75e-01 8.51e-01 0.11000 8.96e-02 0.063800 4.77e-01 6.13e-01
CELL CYCLE 596 1.69e-03 1.26e-02 0.11000 8.22e-02 0.072600 6.31e-04 2.53e-03
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.43e-01 6.94e-01 0.11000 6.58e-02 -0.087700 6.93e-01 5.99e-01
SIGNALING BY WNT 272 4.36e-03 2.33e-02 0.11000 1.05e-01 0.030900 2.87e-03 3.81e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 2.74e-01 4.48e-01 0.10900 5.39e-02 0.094500 3.62e-01 1.10e-01
HIV TRANSCRIPTION ELONGATION 42 3.47e-01 5.15e-01 0.10800 -1.48e-02 -0.107000 8.68e-01 2.28e-01
MAPK FAMILY SIGNALING CASCADES 290 4.10e-02 1.24e-01 0.10800 6.63e-02 0.085200 5.24e-02 1.27e-02
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 64 1.43e-01 2.92e-01 0.10800 -2.62e-04 0.108000 9.97e-01 1.36e-01
HIV LIFE CYCLE 142 1.91e-01 3.54e-01 0.10800 6.16e-02 0.088300 2.06e-01 6.94e-02
POLYMERASE SWITCHING 14 5.51e-01 7.02e-01 0.10800 -3.60e-02 0.101000 8.15e-01 5.12e-01
SMOOTH MUSCLE CONTRACTION 33 5.68e-01 7.12e-01 0.10700 -3.75e-02 -0.100000 7.09e-01 3.18e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 62 4.17e-01 5.80e-01 0.10700 -4.84e-02 -0.095500 5.10e-01 1.94e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 15 7.46e-01 8.33e-01 0.10700 1.03e-01 0.029200 4.91e-01 8.45e-01
FLT3 SIGNALING IN DISEASE 28 3.64e-01 5.31e-01 0.10700 -1.05e-01 0.017900 3.35e-01 8.70e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 33 2.00e-01 3.62e-01 0.10700 7.01e-02 -0.080400 4.86e-01 4.24e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 6.97e-01 8.00e-01 0.10700 9.70e-02 0.044100 4.11e-01 7.08e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 1.81e-02 6.65e-02 0.10600 1.06e-01 0.001080 3.06e-02 9.82e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 3.47e-01 5.15e-01 0.10500 1.05e-01 0.008630 2.45e-01 9.24e-01
SIGNALING BY LEPTIN 10 6.65e-01 7.79e-01 0.10500 -3.56e-02 0.099000 8.46e-01 5.88e-01
SIGNALING BY NTRK3 TRKC 17 6.97e-01 8.00e-01 0.10500 -2.14e-02 -0.103000 8.78e-01 4.63e-01
RHO GTPASES ACTIVATE ROCKS 19 7.68e-01 8.46e-01 0.10400 -4.50e-02 -0.093900 7.34e-01 4.79e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 7.75e-01 8.51e-01 0.10300 -9.92e-02 -0.028100 5.21e-01 8.56e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 7.95e-01 8.66e-01 0.10300 7.98e-02 0.065000 5.08e-01 5.89e-01
RESOLUTION OF ABASIC SITES AP SITES 38 6.58e-01 7.74e-01 0.10300 -8.58e-02 -0.056300 3.60e-01 5.48e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 2.61e-01 4.33e-01 0.10300 -8.70e-02 0.054200 4.02e-01 6.02e-01
REGULATION OF TP53 ACTIVITY 152 1.36e-01 2.82e-01 0.10200 4.50e-02 0.091800 3.39e-01 5.10e-02
SIGNALING BY NOTCH4 83 1.44e-01 2.92e-01 0.10200 1.01e-01 0.010700 1.10e-01 8.67e-01
INFLAMMASOMES 19 4.93e-01 6.52e-01 0.10200 -9.72e-02 0.030800 4.63e-01 8.16e-01
DEUBIQUITINATION 241 1.07e-01 2.37e-01 0.10200 7.09e-02 0.073100 5.85e-02 5.09e-02
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 3.64e-01 5.31e-01 0.10100 -1.00e-01 -0.013800 2.40e-01 8.72e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 83 3.38e-02 1.08e-01 0.10100 4.89e-02 -0.087900 4.42e-01 1.66e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 1.92e-01 3.54e-01 0.10000 -1.51e-02 0.099000 8.49e-01 2.13e-01
SIGNALING BY ROBO RECEPTORS 207 2.48e-03 1.57e-02 0.10000 9.63e-03 -0.099500 8.12e-01 1.37e-02
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 5.39e-01 6.90e-01 0.09990 -1.96e-02 0.098000 8.82e-01 4.60e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 7.98e-01 8.68e-01 0.09960 -5.26e-02 -0.084600 6.76e-01 5.02e-01
SIGNALING BY CSF3 G CSF 29 5.64e-01 7.07e-01 0.09960 9.79e-02 0.018200 3.62e-01 8.65e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 4.55e-01 6.20e-01 0.09900 -9.16e-02 -0.037500 2.32e-01 6.24e-01
NEUREXINS AND NEUROLIGINS 54 3.98e-01 5.62e-01 0.09890 2.59e-02 0.095400 7.42e-01 2.25e-01
FANCONI ANEMIA PATHWAY 36 3.60e-01 5.28e-01 0.09890 -9.85e-02 0.008750 3.07e-01 9.28e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 7.19e-01 8.13e-01 0.09850 -9.97e-03 -0.098000 9.47e-01 5.11e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 64 4.59e-01 6.20e-01 0.09820 -8.82e-02 -0.043200 2.22e-01 5.50e-01
G PROTEIN BETA GAMMA SIGNALLING 31 5.95e-01 7.28e-01 0.09770 9.44e-02 0.025200 3.63e-01 8.08e-01
NGF STIMULATED TRANSCRIPTION 36 5.53e-01 7.02e-01 0.09750 9.40e-02 0.026000 3.29e-01 7.87e-01
REPRESSION OF WNT TARGET GENES 14 7.11e-01 8.10e-01 0.09730 -9.41e-04 -0.097300 9.95e-01 5.28e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 4.27e-01 5.91e-01 0.09610 8.22e-02 0.049800 1.93e-01 4.30e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 74 5.02e-01 6.59e-01 0.09600 -7.88e-02 -0.054900 2.41e-01 4.14e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 5.73e-01 7.16e-01 0.09580 2.21e-02 0.093200 8.26e-01 3.54e-01
SIGNALLING TO RAS 19 6.57e-01 7.74e-01 0.09480 4.10e-03 0.094700 9.75e-01 4.75e-01
MEIOSIS 67 5.80e-01 7.21e-01 0.09480 -6.79e-02 -0.066200 3.37e-01 3.49e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 8.43e-01 9.00e-01 0.09470 5.88e-02 0.074200 6.49e-01 5.66e-01
FLT3 SIGNALING 36 2.98e-01 4.71e-01 0.09460 -3.45e-02 0.088100 7.21e-01 3.60e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 8.77e-01 9.18e-01 0.09450 4.32e-02 0.084100 7.95e-01 6.14e-01
DNA DAMAGE BYPASS 47 3.71e-01 5.36e-01 0.09450 -9.43e-02 -0.006670 2.64e-01 9.37e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 8.20e-01 8.82e-01 0.09440 -9.29e-02 -0.016400 5.94e-01 9.25e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 1.29e-01 2.73e-01 0.09400 -6.92e-02 0.063700 3.79e-01 4.19e-01
INFECTIOUS DISEASE 736 2.40e-03 1.54e-02 0.09230 7.53e-02 0.053400 5.34e-04 1.40e-02
ION CHANNEL TRANSPORT 143 1.20e-01 2.59e-01 0.09230 2.40e-02 0.089100 6.21e-01 6.61e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 7.27e-01 8.20e-01 0.09220 8.99e-02 0.020400 4.86e-01 8.74e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 60 1.15e-01 2.50e-01 0.09190 -6.96e-02 0.060000 3.51e-01 4.22e-01
TELOMERE MAINTENANCE 81 3.41e-01 5.12e-01 0.09180 -2.92e-02 -0.087000 6.50e-01 1.76e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 5.60e-01 7.04e-01 0.09160 -9.15e-02 -0.003660 4.02e-01 9.73e-01
SIGNALING BY ERBB2 48 6.12e-01 7.41e-01 0.09130 4.16e-02 0.081300 6.18e-01 3.30e-01
SIGNALING BY FGFR4 IN DISEASE 11 7.30e-01 8.22e-01 0.09110 2.33e-02 -0.088100 8.93e-01 6.13e-01
PLATELET HOMEOSTASIS 78 3.02e-01 4.74e-01 0.09100 2.04e-02 0.088700 7.56e-01 1.76e-01
IRAK4 DEFICIENCY TLR2 4 14 8.91e-01 9.30e-01 0.09030 -7.42e-02 -0.051400 6.31e-01 7.39e-01
METABOLISM OF STEROID HORMONES 21 7.99e-01 8.68e-01 0.08990 8.17e-02 0.037300 5.17e-01 7.67e-01
MAP2K AND MAPK ACTIVATION 36 7.18e-01 8.13e-01 0.08960 7.79e-02 0.044300 4.18e-01 6.46e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.92e-01 7.98e-01 0.08880 -8.46e-02 0.027100 5.97e-01 8.66e-01
HCMV LATE EVENTS 68 1.44e-01 2.92e-01 0.08880 -2.79e-02 0.084300 6.91e-01 2.29e-01
VISUAL PHOTOTRANSDUCTION 61 1.48e-01 2.98e-01 0.08830 4.18e-02 -0.077800 5.73e-01 2.94e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 23 7.60e-01 8.42e-01 0.08790 -2.92e-02 -0.082900 8.09e-01 4.91e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 7.59e-01 8.41e-01 0.08790 -8.62e-02 0.017000 6.21e-01 9.22e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 5.53e-01 7.02e-01 0.08760 -1.48e-03 0.087600 9.89e-01 4.15e-01
TRANSLESION SYNTHESIS BY POLH 19 7.88e-01 8.60e-01 0.08760 -2.61e-02 -0.083600 8.44e-01 5.28e-01
ACYL CHAIN REMODELLING OF PS 14 8.29e-01 8.87e-01 0.08750 2.27e-02 0.084500 8.83e-01 5.84e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.47e-01 2.95e-01 0.08730 6.65e-02 -0.056600 3.77e-01 4.52e-01
IRS MEDIATED SIGNALLING 41 2.90e-01 4.63e-01 0.08670 -7.62e-02 0.041300 3.99e-01 6.47e-01
SIGNALING BY NOTCH3 48 3.91e-01 5.54e-01 0.08660 -5.26e-05 0.086600 9.99e-01 2.99e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 179 4.71e-02 1.34e-01 0.08660 8.62e-02 0.007910 4.68e-02 8.55e-01
MUSCLE CONTRACTION 160 4.51e-02 1.31e-01 0.08620 -8.62e-02 0.000526 6.00e-02 9.91e-01
OXIDATIVE STRESS INDUCED SENESCENCE 81 3.71e-01 5.36e-01 0.08620 -2.53e-02 -0.082400 6.94e-01 2.00e-01
AMYLOID FIBER FORMATION 61 5.18e-01 6.73e-01 0.08620 -3.13e-02 -0.080300 6.73e-01 2.78e-01
SIGNALING BY NOTCH2 33 7.96e-01 8.66e-01 0.08590 6.63e-02 0.054600 5.10e-01 5.88e-01
G ALPHA S SIGNALLING EVENTS 107 4.84e-01 6.44e-01 0.08550 6.56e-02 0.054800 2.41e-01 3.28e-01
PRE NOTCH EXPRESSION AND PROCESSING 67 6.03e-01 7.36e-01 0.08520 -7.11e-02 -0.046900 3.14e-01 5.07e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 5.35e-01 6.88e-01 0.08510 -3.05e-02 -0.079400 6.85e-01 2.92e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 13 6.93e-01 7.98e-01 0.08490 3.59e-02 -0.076900 8.23e-01 6.31e-01
PI 3K CASCADE FGFR4 13 7.51e-01 8.37e-01 0.08450 -8.36e-02 0.012200 6.02e-01 9.39e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 16 6.23e-01 7.49e-01 0.08380 6.82e-02 -0.048700 6.37e-01 7.36e-01
PYROPTOSIS 21 6.10e-01 7.40e-01 0.08360 1.92e-02 -0.081400 8.79e-01 5.19e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 5.55e-01 7.02e-01 0.08320 8.28e-02 -0.008010 4.40e-01 9.40e-01
SIGNALING BY NOTCH1 75 5.49e-01 7.01e-01 0.08310 4.03e-02 0.072600 5.46e-01 2.77e-01
MEIOTIC SYNAPSIS 43 7.65e-01 8.44e-01 0.08300 -5.84e-02 -0.059000 5.08e-01 5.03e-01
G2 M DNA DAMAGE CHECKPOINT 69 6.38e-01 7.58e-01 0.08290 -5.17e-02 -0.064800 4.58e-01 3.52e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 7.92e-01 8.64e-01 0.08290 8.27e-02 0.004530 5.92e-01 9.77e-01
RA BIOSYNTHESIS PATHWAY 13 8.40e-01 8.97e-01 0.08260 -8.11e-02 -0.015800 6.13e-01 9.21e-01
RET SIGNALING 38 7.87e-01 8.60e-01 0.08240 5.36e-02 0.062600 5.68e-01 5.04e-01
GAB1 SIGNALOSOME 14 6.72e-01 7.84e-01 0.08220 -6.75e-02 0.047000 6.62e-01 7.61e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 2.89e-01 4.63e-01 0.08200 -6.10e-02 0.054900 4.89e-01 5.34e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 7.47e-01 8.33e-01 0.08190 -3.64e-02 0.073400 8.34e-01 6.73e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 6.87e-01 7.94e-01 0.08170 -6.15e-02 -0.053900 4.06e-01 4.67e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 5.09e-01 6.65e-01 0.08120 5.12e-02 -0.063100 6.64e-01 5.93e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 8.49e-01 9.01e-01 0.08100 -6.75e-02 -0.044800 5.67e-01 7.04e-01
ENDOGENOUS STEROLS 20 6.65e-01 7.79e-01 0.08050 -7.95e-02 0.012900 5.38e-01 9.20e-01
CARDIAC CONDUCTION 107 5.32e-02 1.46e-01 0.08030 -6.14e-02 0.051700 2.73e-01 3.56e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 8.97e-01 9.36e-01 0.08020 -5.07e-02 -0.062200 7.10e-01 6.48e-01
DISEASES OF MITOTIC CELL CYCLE 37 8.07e-01 8.72e-01 0.07990 5.80e-02 0.055000 5.42e-01 5.63e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 9.03e-01 9.37e-01 0.07920 2.42e-02 0.075400 8.95e-01 6.80e-01
SIGNALING BY FGFR2 IIIA TM 19 8.61e-01 9.11e-01 0.07860 -3.41e-02 -0.070800 7.97e-01 5.93e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 5.10e-01 6.67e-01 0.07840 7.09e-02 0.033500 2.59e-01 5.93e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 2.75e-01 4.49e-01 0.07840 7.79e-02 0.008370 1.92e-01 8.89e-01
POTASSIUM CHANNELS 90 5.55e-01 7.02e-01 0.07810 6.62e-02 0.041500 2.78e-01 4.96e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 9.11e-01 9.43e-01 0.07760 -6.44e-02 -0.043200 6.66e-01 7.72e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 8.21e-01 8.82e-01 0.07750 5.69e-02 0.052700 5.55e-01 5.85e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 7.32e-01 8.23e-01 0.07740 -3.63e-02 0.068300 8.21e-01 6.70e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 12 7.76e-01 8.51e-01 0.07710 2.27e-02 -0.073700 8.92e-01 6.59e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 110 4.22e-01 5.85e-01 0.07690 -3.17e-02 -0.070100 5.66e-01 2.04e-01
REGULATED NECROSIS 46 3.58e-01 5.26e-01 0.07680 2.90e-02 -0.071200 7.34e-01 4.04e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 8.07e-01 8.72e-01 0.07680 1.36e-02 0.075600 9.20e-01 5.79e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 6.70e-01 7.84e-01 0.07680 -1.54e-04 0.076800 9.99e-01 4.98e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 7.65e-01 8.44e-01 0.07650 7.59e-02 0.009580 5.47e-01 9.39e-01
MRNA SPLICING 188 9.71e-03 4.20e-02 0.07630 4.90e-02 -0.058500 2.47e-01 1.67e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 150 2.72e-02 9.07e-02 0.07620 4.20e-02 -0.063600 3.75e-01 1.79e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.72e-01 9.15e-01 0.07510 -7.05e-02 -0.025700 6.25e-01 8.59e-01
FGFR2 ALTERNATIVE SPLICING 25 6.37e-01 7.58e-01 0.07480 1.38e-02 -0.073500 9.05e-01 5.25e-01
FOXO MEDIATED TRANSCRIPTION 57 4.73e-01 6.32e-01 0.07400 -7.39e-02 -0.004450 3.35e-01 9.54e-01
INSULIN RECEPTOR SIGNALLING CASCADE 46 3.85e-01 5.47e-01 0.07340 -2.95e-02 0.067200 7.29e-01 4.31e-01
FRS MEDIATED FGFR2 SIGNALING 19 8.45e-01 9.00e-01 0.07320 -2.15e-02 -0.070000 8.71e-01 5.97e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 5.83e-01 7.21e-01 0.07260 3.71e-02 -0.062400 7.48e-01 5.89e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 8.06e-01 8.72e-01 0.07200 3.48e-03 0.071900 9.80e-01 6.08e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 8.99e-01 9.37e-01 0.07200 1.20e-02 0.071000 9.47e-01 6.98e-01
APOPTOTIC EXECUTION PHASE 45 8.11e-01 8.74e-01 0.07130 5.33e-02 0.047400 5.37e-01 5.82e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 8.28e-01 8.87e-01 0.07130 -1.05e-02 0.070500 9.50e-01 6.72e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 9.37e-01 9.62e-01 0.07120 5.15e-02 0.049200 7.39e-01 7.50e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 6.29e-01 7.52e-01 0.07110 -6.31e-02 0.032700 6.00e-01 7.86e-01
UCH PROTEINASES 89 1.54e-01 3.04e-01 0.07060 5.65e-02 -0.042300 3.57e-01 4.90e-01
POTENTIAL THERAPEUTICS FOR SARS 77 6.10e-01 7.40e-01 0.07060 6.38e-02 0.030300 3.33e-01 6.46e-01
CHROMOSOME MAINTENANCE 104 5.22e-01 6.76e-01 0.07040 -3.09e-02 -0.063300 5.86e-01 2.65e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.77e-01 7.86e-01 0.07010 -6.85e-02 -0.015000 4.42e-01 8.66e-01
DUAL INCISION IN TC NER 65 6.61e-01 7.76e-01 0.06970 -6.33e-02 -0.029100 3.77e-01 6.85e-01
VOLTAGE GATED POTASSIUM CHANNELS 38 8.24e-01 8.83e-01 0.06950 3.78e-02 0.058300 6.87e-01 5.34e-01
CYTOPROTECTION BY HMOX1 119 8.79e-02 2.07e-01 0.06910 4.75e-02 -0.050200 3.71e-01 3.45e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 46 6.72e-01 7.84e-01 0.06890 -1.64e-02 -0.067000 8.48e-01 4.32e-01
SUMOYLATION 168 3.63e-02 1.13e-01 0.06870 -5.55e-02 0.040500 2.15e-01 3.66e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 66 5.28e-01 6.82e-01 0.06830 -1.07e-02 -0.067400 8.81e-01 3.44e-01
HCMV EARLY EVENTS 83 6.71e-01 7.84e-01 0.06760 3.68e-02 0.056700 5.62e-01 3.72e-01
HATS ACETYLATE HISTONES 96 3.09e-01 4.81e-01 0.06740 -6.74e-02 0.001970 2.54e-01 9.73e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 7.62e-01 8.43e-01 0.06690 6.51e-02 -0.015600 6.33e-01 9.09e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 11 9.55e-01 9.72e-01 0.06590 -4.06e-02 -0.051900 8.15e-01 7.66e-01
COMPLEMENT CASCADE 26 9.02e-01 9.37e-01 0.06570 4.96e-02 0.043000 6.61e-01 7.04e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 8.73e-01 9.15e-01 0.06540 3.01e-02 0.058100 7.90e-01 6.08e-01
PHOSPHORYLATION OF THE APC C 17 9.14e-01 9.45e-01 0.06540 5.82e-02 0.029700 6.78e-01 8.32e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 33 5.52e-01 7.02e-01 0.06520 -3.97e-02 0.051700 6.93e-01 6.07e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 9.09e-01 9.41e-01 0.06450 6.31e-02 0.013300 7.05e-01 9.36e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 7.82e-01 8.56e-01 0.06440 3.68e-02 0.052800 6.25e-01 4.83e-01
STIMULI SENSING CHANNELS 76 2.64e-01 4.35e-01 0.06400 -4.35e-02 0.046800 5.12e-01 4.80e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 604 8.27e-04 7.43e-03 0.06370 6.33e-02 -0.007360 8.13e-03 7.58e-01
P75NTR SIGNALS VIA NF KB 15 8.68e-01 9.13e-01 0.06360 -5.04e-03 -0.063400 9.73e-01 6.71e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 541 1.61e-03 1.23e-02 0.06350 -8.09e-03 0.063000 7.48e-01 1.25e-02
G2 M CHECKPOINTS 136 1.69e-01 3.21e-01 0.06300 6.15e-02 -0.013500 2.16e-01 7.86e-01
TRNA PROCESSING 105 4.19e-01 5.82e-01 0.06260 8.93e-03 0.062000 8.74e-01 2.73e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 2.31e-01 4.01e-01 0.06250 6.02e-02 -0.016800 2.80e-01 7.63e-01
SEMAPHORIN INTERACTIONS 64 6.29e-01 7.52e-01 0.06240 -6.08e-02 -0.014000 4.00e-01 8.46e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 9.14e-01 9.45e-01 0.06240 -4.05e-02 -0.047500 7.26e-01 6.81e-01
PYRIMIDINE CATABOLISM 10 9.02e-01 9.37e-01 0.06210 1.43e-03 -0.062100 9.94e-01 7.34e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 7.14e-01 8.12e-01 0.06150 -5.05e-02 -0.035100 4.13e-01 5.69e-01
SIGNALING BY FGFR 74 5.82e-01 7.21e-01 0.06110 5.99e-02 0.011700 3.73e-01 8.62e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 1.87e-01 3.48e-01 0.06040 -4.57e-02 0.039400 4.12e-01 4.79e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 6.49e-01 7.67e-01 0.05940 2.08e-02 -0.055700 8.36e-01 5.80e-01
DNA REPAIR 295 1.27e-01 2.71e-01 0.05890 -5.81e-02 -0.009870 8.65e-02 7.71e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.91e-01 9.30e-01 0.05860 -1.36e-02 0.057000 9.41e-01 7.55e-01
ANTIGEN PROCESSING CROSS PRESENTATION 96 3.62e-01 5.28e-01 0.05850 5.78e-02 -0.008810 3.28e-01 8.81e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 4.59e-01 6.20e-01 0.05700 -2.20e-02 0.052600 7.63e-01 4.71e-01
EXTENSION OF TELOMERES 49 8.47e-01 9.00e-01 0.05600 2.95e-02 0.047600 7.21e-01 5.64e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 8.66e-01 9.13e-01 0.05500 -2.19e-02 -0.050400 8.22e-01 6.06e-01
DUAL INCISION IN GG NER 41 7.46e-01 8.33e-01 0.05490 -5.48e-02 -0.003790 5.44e-01 9.67e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.49e-01 2.99e-01 0.05450 1.99e-02 -0.050800 6.54e-01 2.51e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 8.48e-01 9.01e-01 0.05430 4.81e-02 -0.025100 7.55e-01 8.71e-01
ELASTIC FIBRE FORMATION 38 6.32e-01 7.53e-01 0.05310 -3.94e-02 0.035600 6.74e-01 7.05e-01
TP53 REGULATES METABOLIC GENES 85 6.36e-01 7.57e-01 0.05310 -1.13e-02 -0.051900 8.57e-01 4.09e-01
SIGNALING BY FGFR2 63 6.73e-01 7.85e-01 0.05270 5.25e-02 0.005340 4.72e-01 9.42e-01
ANTIMICROBIAL PEPTIDES 15 9.49e-01 9.68e-01 0.05230 2.25e-02 0.047200 8.80e-01 7.52e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 9.29e-01 9.57e-01 0.05170 2.42e-02 0.045700 8.40e-01 7.05e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 7.14e-01 8.11e-01 0.05130 -2.15e-02 0.046500 8.31e-01 6.44e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 20 8.33e-01 8.91e-01 0.04930 4.60e-02 -0.017900 7.22e-01 8.90e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 4.21e-01 5.83e-01 0.04900 4.55e-02 -0.018200 4.41e-01 7.58e-01
RHO GTPASES ACTIVATE PAKS 21 8.18e-01 8.81e-01 0.04880 4.31e-02 -0.023000 7.33e-01 8.55e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 7.35e-01 8.25e-01 0.04870 -4.58e-03 -0.048400 9.52e-01 5.27e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 8.64e-01 9.12e-01 0.04840 2.62e-02 -0.040700 8.61e-01 7.85e-01
SURFACTANT METABOLISM 16 9.26e-01 9.55e-01 0.04810 4.75e-02 0.007420 7.42e-01 9.59e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 7.16e-01 8.12e-01 0.04550 1.85e-03 -0.045500 9.80e-01 5.46e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 6.88e-01 7.94e-01 0.04530 -1.74e-02 0.041800 8.34e-01 6.17e-01
MRNA CAPPING 29 9.41e-01 9.64e-01 0.04480 3.75e-02 0.024400 7.26e-01 8.20e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 8.20e-01 8.82e-01 0.04440 -8.59e-03 0.043500 9.34e-01 6.75e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 8.06e-01 8.72e-01 0.04430 1.70e-02 0.040800 7.93e-01 5.31e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 9.25e-01 9.55e-01 0.04410 6.18e-03 -0.043700 9.69e-01 7.85e-01
EXTRACELLULAR MATRIX ORGANIZATION 250 4.82e-01 6.43e-01 0.04360 -4.12e-02 -0.014200 2.63e-01 6.99e-01
SIGNALING BY NUCLEAR RECEPTORS 228 6.84e-01 7.92e-01 0.04310 3.09e-02 0.030100 4.22e-01 4.35e-01
METABOLISM OF RNA 644 8.33e-03 3.72e-02 0.04300 2.36e-02 -0.036000 3.09e-01 1.21e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 5.85e-01 7.22e-01 0.04290 -3.85e-02 0.018900 5.67e-01 7.79e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 8.53e-01 9.04e-01 0.04280 -1.34e-02 0.040600 9.09e-01 7.31e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 6.62e-01 7.77e-01 0.04270 -3.63e-02 0.022500 6.42e-01 7.73e-01
REGULATION OF BETA CELL DEVELOPMENT 30 9.32e-01 9.59e-01 0.04270 -3.85e-02 -0.018400 7.15e-01 8.62e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 8.65e-01 9.12e-01 0.04240 -4.07e-02 0.011700 7.35e-01 9.22e-01
MRNA SPLICING MINOR PATHWAY 52 6.78e-01 7.87e-01 0.04200 3.34e-02 -0.025500 6.77e-01 7.50e-01
SIGNALING BY PDGFR IN DISEASE 20 9.01e-01 9.37e-01 0.04180 -4.62e-03 0.041500 9.71e-01 7.48e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 50 8.90e-01 9.30e-01 0.04150 -3.80e-02 -0.016700 6.42e-01 8.38e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 9.03e-01 9.37e-01 0.04150 4.08e-02 0.007750 6.99e-01 9.41e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 7.82e-01 8.56e-01 0.04130 7.38e-03 0.040700 9.14e-01 5.51e-01
DNA DOUBLE STRAND BREAK RESPONSE 55 8.46e-01 9.00e-01 0.04120 1.02e-02 0.040000 8.96e-01 6.08e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 9.33e-01 9.59e-01 0.04110 3.90e-02 0.013100 7.31e-01 9.08e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 1.98e-01 3.61e-01 0.04090 3.45e-02 -0.021900 3.61e-01 5.62e-01
SIGNALING BY ERYTHROPOIETIN 24 8.56e-01 9.06e-01 0.04080 -3.69e-02 0.017200 7.54e-01 8.84e-01
CA2 PATHWAY 59 6.59e-01 7.75e-01 0.04060 2.99e-02 -0.027500 6.92e-01 7.15e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 7.12e-01 8.11e-01 0.03940 3.92e-02 -0.004100 5.60e-01 9.51e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 9.65e-01 9.79e-01 0.03930 -3.50e-02 -0.018000 7.92e-01 8.92e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 7.43e-01 8.33e-01 0.03920 -3.35e-02 0.020400 6.92e-01 8.09e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 9.48e-01 9.68e-01 0.03710 3.55e-02 -0.010600 8.38e-01 9.51e-01
NONHOMOLOGOUS END JOINING NHEJ 46 9.42e-01 9.64e-01 0.03690 -2.89e-02 -0.022900 7.34e-01 7.88e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 9.33e-01 9.59e-01 0.03570 -3.53e-02 -0.005610 7.56e-01 9.61e-01
SIGNALING BY NOTCH 192 6.42e-01 7.61e-01 0.03490 3.41e-02 0.007300 4.15e-01 8.62e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 8.72e-01 9.15e-01 0.03460 1.02e-02 -0.033100 9.21e-01 7.46e-01
SIGNALING BY PDGF 56 8.44e-01 9.00e-01 0.03460 -3.46e-02 -0.000609 6.55e-01 9.94e-01
HIV TRANSCRIPTION INITIATION 45 8.11e-01 8.74e-01 0.03410 -3.01e-02 0.015900 7.27e-01 8.53e-01
NUCLEOTIDE EXCISION REPAIR 110 7.84e-01 8.58e-01 0.03240 3.20e-02 0.004690 5.62e-01 9.32e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.42e-01 9.64e-01 0.03210 -3.04e-02 -0.010500 7.49e-01 9.12e-01
IRAK1 RECRUITS IKK COMPLEX 14 9.86e-01 9.93e-01 0.03210 2.01e-02 0.025100 8.96e-01 8.71e-01
MITOCHONDRIAL BIOGENESIS 92 7.45e-01 8.33e-01 0.03100 -3.02e-02 0.006940 6.17e-01 9.08e-01
SIGNALING BY ERBB2 IN CANCER 25 9.75e-01 9.88e-01 0.03080 1.65e-02 0.026000 8.87e-01 8.22e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 9.84e-01 9.92e-01 0.02980 2.21e-02 0.020100 8.64e-01 8.76e-01
FRS MEDIATED FGFR1 SIGNALING 18 9.36e-01 9.62e-01 0.02950 2.44e-02 -0.016700 8.58e-01 9.02e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 9.55e-01 9.72e-01 0.02950 2.94e-02 -0.003090 8.29e-01 9.82e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 9.79e-01 9.90e-01 0.02760 2.58e-02 0.009670 8.45e-01 9.42e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 9.52e-01 9.71e-01 0.02610 2.00e-02 0.016800 7.60e-01 7.98e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 9.45e-01 9.67e-01 0.02580 1.36e-02 0.022000 8.35e-01 7.38e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.98e-01 9.37e-01 0.02500 -1.43e-02 0.020500 8.74e-01 8.21e-01
NERVOUS SYSTEM DEVELOPMENT 553 3.42e-01 5.12e-01 0.02310 2.15e-02 -0.008400 3.89e-01 7.36e-01
METALLOPROTEASE DUBS 26 9.55e-01 9.72e-01 0.02230 2.13e-02 -0.006740 8.51e-01 9.53e-01
SENSORY PROCESSING OF SOUND 62 9.59e-01 9.74e-01 0.02220 -8.75e-03 -0.020400 9.05e-01 7.81e-01
DEVELOPMENTAL BIOLOGY 830 2.94e-01 4.67e-01 0.02150 4.73e-03 -0.021000 8.18e-01 3.06e-01
DAP12 SIGNALING 24 9.90e-01 9.94e-01 0.02130 -1.62e-02 -0.013800 8.91e-01 9.07e-01
RNA POLYMERASE II TRANSCRIPTION 1097 2.96e-01 4.68e-01 0.02020 -2.01e-02 0.001810 2.65e-01 9.20e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 9.86e-01 9.93e-01 0.01930 1.92e-02 0.002290 8.91e-01 9.87e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 9.56e-01 9.72e-01 0.01930 -1.24e-02 0.014800 9.09e-01 8.92e-01
ARACHIDONIC ACID METABOLISM 38 9.83e-01 9.92e-01 0.01930 8.79e-03 0.017200 9.25e-01 8.55e-01
TRANSCRIPTIONAL REGULATION BY TP53 343 8.69e-01 9.13e-01 0.01610 5.01e-03 0.015300 8.74e-01 6.26e-01
SYNDECAN INTERACTIONS 27 9.92e-01 9.96e-01 0.01430 1.32e-02 0.005430 9.05e-01 9.61e-01
ESR MEDIATED SIGNALING 171 8.67e-01 9.13e-01 0.01400 1.05e-02 -0.009290 8.13e-01 8.34e-01
PERK REGULATES GENE EXPRESSION 28 9.79e-01 9.90e-01 0.01360 1.11e-02 -0.007850 9.19e-01 9.43e-01
SIGNALING BY FGFR IN DISEASE 57 9.80e-01 9.90e-01 0.01270 -1.26e-02 -0.001370 8.69e-01 9.86e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 9.97e-01 9.97e-01 0.01130 5.77e-03 0.009660 9.62e-01 9.36e-01
TRANSCRIPTION OF THE HIV GENOME 67 9.89e-01 9.94e-01 0.01070 9.91e-03 0.004010 8.89e-01 9.55e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 9.93e-01 9.96e-01 0.00989 -3.20e-03 0.009360 9.81e-01 9.44e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.97e-01 9.97e-01 0.00972 -5.63e-03 -0.007930 9.58e-01 9.41e-01
CELLULAR SENESCENCE 144 9.76e-01 9.89e-01 0.00875 1.02e-03 0.008690 9.83e-01 8.57e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.88e-01 9.94e-01 0.00590 5.12e-03 -0.002930 9.35e-01 9.63e-01
AURKA ACTIVATION BY TPX2 71 9.97e-01 9.97e-01 0.00315 -2.93e-03 0.001160 9.66e-01 9.86e-01


Detailed Gene set reports


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
metric value
setSize 12
pMANOVA 0.000958
p.adjustMANOVA 0.00823
s.dist 0.784
s.LPS 0.608
s.OVA 0.494
p.LPS 0.000265
p.OVA 0.00303




Top 20 genes
Gene LPS OVA
Fads2 8261 8470
Fads1 8175 7161
Hsd17b4 6523 8886
Acox1 6025 8680
Elovl1 7422 6273
Elovl2 2596 8770
Acsl1 2698 7510
Scp2 3782 4255
Elovl5 2615 6088

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All member genes
LPS OVA
Abcd1 1852 -4213
Acaa1a 5253 -514
Acot8 3521 -2840
Acox1 6025 8680
Acsl1 2698 7510
Elovl1 7422 6273
Elovl2 2596 8770
Elovl5 2615 6088
Fads1 8175 7161
Fads2 8261 8470
Hsd17b4 6523 8886
Scp2 3782 4255



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 2.43e-07
p.adjustMANOVA 9.85e-06
s.dist 0.776
s.LPS 0.707
s.OVA 0.32
p.LPS 9.37e-08
p.OVA 0.0156




Top 20 genes
Gene LPS OVA
Cct6a 8085 8933
Tubb2b 7453 8823
Tcp1 6593 8066
Cct3 7101 6548
Cct5 7277 5981
Tubb2a 8077 4592
Tuba1b 7821 4723
Cct4 6208 5466
Tuba4a 7159 3675
Tubb4a 7466 3029
Cct8 6441 3130
Cct7 4809 3665
Tubb4b 7571 2010
Cct2 3803 3757
Tuba1a 7018 1821

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All member genes
LPS OVA
Cct2 3803 3757
Cct3 7101 6548
Cct4 6208 5466
Cct5 7277 5981
Cct6a 8085 8933
Cct7 4809 3665
Cct8 6441 3130
Tcp1 6593 8066
Tuba1a 7018 1821
Tuba1b 7821 4723
Tuba1c 4454 -1802
Tuba4a 7159 3675
Tuba8 -5535 -1623
Tubb2a 8077 4592
Tubb2b 7453 8823
Tubb3 5803 -2348
Tubb4a 7466 3029
Tubb4b 7571 2010
Tubb6 1793 -4650



PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
metric value
setSize 12
pMANOVA 0.00227
p.adjustMANOVA 0.015
s.dist 0.741
s.LPS 0.559
s.OVA 0.486
p.LPS 0.000792
p.OVA 0.00359




Top 20 genes
Gene LPS OVA
Paics 7022 9071
Gart 7332 7646
Atic 6666 7906
Impdh2 7540 6135
Adss 6878 6718
Adsl 5385 7748
Gmps 6735 3065
Adssl1 5308 2668
Impdh1 3105 3842
Ppat 1904 4974
Lhpp 1152 2702

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All member genes
LPS OVA
Adsl 5385 7748
Adss 6878 6718
Adssl1 5308 2668
Atic 6666 7906
Gart 7332 7646
Gmps 6735 3065
Impdh1 3105 3842
Impdh2 7540 6135
Lhpp 1152 2702
Paics 7022 9071
Pfas -5395 -4860
Ppat 1904 4974



RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
metric value
setSize 10
pMANOVA 0.00724
p.adjustMANOVA 0.0334
s.dist 0.729
s.LPS 0.553
s.OVA 0.475
p.LPS 0.00245
p.OVA 0.00933




Top 20 genes
Gene LPS OVA
Htr7 7842 9008
Cul3 5783 8121
Lrrc41 4554 7806
Plin3 5227 6667
Hgs 5302 5800
Rab9b 5884 4356
Vhl 2238 2563
Rhobtb3 398 6657

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All member genes
LPS OVA
Ccne1 7380 -2650
Cul3 5783 8121
Hgs 5302 5800
Htr7 7842 9008
Lrrc41 4554 7806
Plin3 5227 6667
Rab9 -453 -1250
Rab9b 5884 4356
Rhobtb3 398 6657
Vhl 2238 2563



CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
metric value
setSize 22
pMANOVA 2.54e-05
p.adjustMANOVA 0.000481
s.dist 0.728
s.LPS 0.519
s.OVA 0.511
p.LPS 2.5e-05
p.OVA 3.39e-05




Top 20 genes
Gene LPS OVA
Fh1 7863 9041
Idh3a 7936 8737
Idh2 8195 7982
Dld 6857 8590
Sucla2 6879 7731
Idh3b 6611 7636
Suclg2 5299 8528
Aco2 4696 8516
Dlst 6427 6200
Sdha 3974 6855
Sdhd 5042 4956
Idh3g 4268 4953
Cs 3810 5375
Ogdh 3630 4629
Mdh2 5287 2235
Nnt 3338 3242
Sdhb 2150 1639
Suclg1 3531 978
Sdhc 1187 1343

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All member genes
LPS OVA
Aco2 4696 8516
Cs 3810 5375
Dld 6857 8590
Dlst 6427 6200
Fahd1 1716 -3995
Fh1 7863 9041
Idh2 8195 7982
Idh3a 7936 8737
Idh3b 6611 7636
Idh3g 4268 4953
Mdh2 5287 2235
Me2 -3379 6182
Me3 -4810 -981
Nnt 3338 3242
Ogdh 3630 4629
Sdha 3974 6855
Sdhb 2150 1639
Sdhc 1187 1343
Sdhd 5042 4956
Sucla2 6879 7731
Suclg1 3531 978
Suclg2 5299 8528



BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM
metric value
setSize 23
pMANOVA 2.82e-05
p.adjustMANOVA 0.000527
s.dist 0.7
s.LPS 0.534
s.OVA 0.452
p.LPS 9.32e-06
p.OVA 0.000173




Top 20 genes
Gene LPS OVA
Lztfl1 6459 8899
Mkks 7976 7175
Tcp1 6593 8066
Mchr1 7206 7350
Arl6 6927 7336
Cct3 7101 6548
Bbs10 7829 5566
Cct5 7277 5981
Rab3ip 6180 7022
Bbs1 5886 7036
Ttc8 6129 5688
Cct4 6208 5466
Bbs7 4485 6357
Smo 5017 5074
Cct8 6441 3130
Cct2 3803 3757
Bbs4 1644 5486
Bbs2 2145 306

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All member genes
LPS OVA
Arl6 6927 7336
Bbip1 1822 -684
Bbs1 5886 7036
Bbs10 7829 5566
Bbs12 -5740 -115
Bbs2 2145 306
Bbs4 1644 5486
Bbs5 -5655 -4831
Bbs7 4485 6357
Bbs9 7185 -196
Cct2 3803 3757
Cct3 7101 6548
Cct4 6208 5466
Cct5 7277 5981
Cct8 6441 3130
Lztfl1 6459 8899
Mchr1 7206 7350
Mkks 7976 7175
Rab3ip 6180 7022
Smo 5017 5074
Sstr3 -5327 3299
Tcp1 6593 8066
Ttc8 6129 5688



OLFACTORY SIGNALING PATHWAY

OLFACTORY SIGNALING PATHWAY
metric value
setSize 37
pMANOVA 1.32e-07
p.adjustMANOVA 5.97e-06
s.dist 0.686
s.LPS -0.472
s.OVA -0.498
p.LPS 6.88e-07
p.OVA 1.55e-07




Top 20 genes
Gene LPS OVA
Olfr981 -9067 -8167
Olfr354 -9003 -8150
Olfr1310 -8828 -8166
Olfr635 -8904 -7899
Olfr1192-ps1 -8764 -8005
Olfr1309 -8264 -7776
Olfr796 -8485 -7178
Olfr986 -8019 -7502
Olfr63 -8275 -7036
Olfr90 -7285 -7906
Olfr1564 -8451 -6482
Olfr78 -7248 -6810
Olfr804 -6658 -7410
Gng13 -6569 -7493
Olfr2 -8410 -5773
Olfr1385 -6482 -7472
Olfr735 -8350 -5746
Rtp4 -9122 -4987
Olfr161 -5805 -7312
Olfr365 -5413 -7295

Click HERE to show all gene set members

All member genes
LPS OVA
Gnal 4209 3994
Gnb1 6308 4847
Gng13 -6569 -7493
Olfr1192-ps1 -8764 -8005
Olfr1309 -8264 -7776
Olfr1310 -8828 -8166
Olfr137 -5407 -1228
Olfr1385 -6482 -7472
Olfr147 -3182 -3016
Olfr1507 -581 -6839
Olfr1564 -8451 -6482
Olfr161 -5805 -7312
Olfr2 -8410 -5773
Olfr287 -7622 472
Olfr31 -6704 -5391
Olfr354 -9003 -8150
Olfr365 -5413 -7295
Olfr552 349 -1370
Olfr558 -2442 -7210
Olfr63 -8275 -7036
Olfr635 -8904 -7899
Olfr648 -4349 1866
Olfr735 -8350 -5746
Olfr78 -7248 -6810
Olfr796 -8485 -7178
Olfr804 -6658 -7410
Olfr90 -7285 -7906
Olfr95 310 -2933
Olfr981 -9067 -8167
Olfr986 -8019 -7502
Reep1 2390 6990
Reep2 5086 3114
Reep3 -344 5264
Reep4 -4397 -271
Reep5 6835 6529
Reep6 -575 -268
Rtp4 -9122 -4987



CALNEXIN CALRETICULIN CYCLE

CALNEXIN CALRETICULIN CYCLE
metric value
setSize 26
pMANOVA 3.26e-05
p.adjustMANOVA 0.00059
s.dist 0.661
s.LPS 0.455
s.OVA 0.479
p.LPS 5.9e-05
p.OVA 2.32e-05




Top 20 genes
Gene LPS OVA
Derl2 8155 9168
Pdia3 7836 8348
Ganab 7241 8914
Man1b1 6092 8607
Edem2 5598 9207
Os9 6542 7667
Calr 8166 5149
Amfr 5390 7797
Uggt1 5261 7777
Syvn1 5130 7943
Marchf6 5800 6991
Rnf139 5265 7108
Ubc 4469 5871
Edem3 2254 6454
Rnf185 6657 2119
Canx 6321 1740
Rnf5 5623 1021
Prkcsh 7664 96

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All member genes
LPS OVA
Amfr 5390 7797
Calr 8166 5149
Canx 6321 1740
Derl2 8155 9168
Edem1 -1051 5338
Edem2 5598 9207
Edem3 2254 6454
Ganab 7241 8914
Man1b1 6092 8607
Marchf6 5800 6991
Os9 6542 7667
Pdia3 7836 8348
Prkcsh 7664 96
Rnf103 -715 4985
Rnf139 5265 7108
Rnf185 6657 2119
Rnf5 5623 1021
Rps27a -474 -2051
Sel1l -2235 5032
Syvn1 5130 7943
Trim13 -2986 4140
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871
Uggt1 5261 7777
Uggt2 -2714 3827



GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
metric value
setSize 12
pMANOVA 0.00216
p.adjustMANOVA 0.0146
s.dist 0.646
s.LPS 0.575
s.OVA 0.295
p.LPS 0.000568
p.OVA 0.077




Top 20 genes
Gene LPS OVA
Uso1 6804 8727
Mapk1 7048 7970
Rab2a 6425 7199
Blzf1 4950 9002
Mapk3 7650 5139
Gorasp2 7489 4511
Rab1b 6272 4875
Ccnb2 5852 1125

Click HERE to show all gene set members

All member genes
LPS OVA
Blzf1 4950 9002
Ccnb2 5852 1125
Golga2 -3147 -2784
Gorasp1 4083 -243
Gorasp2 7489 4511
Mapk1 7048 7970
Mapk3 7650 5139
Plk1 -4310 -7778
Rab1a 6103 -112
Rab1b 6272 4875
Rab2a 6425 7199
Uso1 6804 8727



NUCLEOBASE BIOSYNTHESIS

NUCLEOBASE BIOSYNTHESIS
metric value
setSize 15
pMANOVA 0.00274
p.adjustMANOVA 0.0172
s.dist 0.636
s.LPS 0.507
s.OVA 0.384
p.LPS 0.00067
p.OVA 0.00994




Top 20 genes
Gene LPS OVA
Paics 7022 9071
Gart 7332 7646
Atic 6666 7906
Impdh2 7540 6135
Adss 6878 6718
Adsl 5385 7748
Umps 7638 4138
Gmps 6735 3065
Adssl1 5308 2668
Impdh1 3105 3842
Ppat 1904 4974
Lhpp 1152 2702
Dhodh 1000 140

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All member genes
LPS OVA
Adsl 5385 7748
Adss 6878 6718
Adssl1 5308 2668
Atic 6666 7906
Cad -2076 -3121
Dhodh 1000 140
Gart 7332 7646
Gmps 6735 3065
Impdh1 3105 3842
Impdh2 7540 6135
Lhpp 1152 2702
Paics 7022 9071
Pfas -5395 -4860
Ppat 1904 4974
Umps 7638 4138



RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
metric value
setSize 13
pMANOVA 0.0103
p.adjustMANOVA 0.0443
s.dist 0.622
s.LPS 0.452
s.OVA 0.427
p.LPS 0.00477
p.OVA 0.00774




Top 20 genes
Gene LPS OVA
Dnm2 7563 9254
Ap2b1 7471 7369
Ap2a2 6935 7060
Ap2m1 7740 4084
Cltc 4452 6224
Ap2a1 6068 3850
Dnm3 2282 5964
Dnal4 7330 1851
Sh3gl2 2837 3272
Dnm1 806 4286

Click HERE to show all gene set members

All member genes
LPS OVA
Ap2a1 6068 3850
Ap2a2 6935 7060
Ap2b1 7471 7369
Ap2m1 7740 4084
Ap2s1 -3446 -4267
Clta 3532 -54
Cltc 4452 6224
Dnal4 7330 1851
Dnm1 806 4286
Dnm2 7563 9254
Dnm3 2282 5964
Ntrk1 -7661 6826
Sh3gl2 2837 3272



N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
metric value
setSize 35
pMANOVA 1.3e-05
p.adjustMANOVA 0.000289
s.dist 0.595
s.LPS 0.42
s.OVA 0.422
p.LPS 1.74e-05
p.OVA 1.53e-05




Top 20 genes
Gene LPS OVA
Derl2 8155 9168
Pdia3 7836 8348
Ganab 7241 8914
Ngly1 7666 7938
Mlec 7511 8004
Derl1 6433 8377
Man1b1 6092 8607
Edem2 5598 9207
Os9 6542 7667
Calr 8166 5149
Amfr 5390 7797
Uggt1 5261 7777
Syvn1 5130 7943
Marchf6 5800 6991
Rnf139 5265 7108
Vcp 7357 4449
Ubc 4469 5871
Rad23b 3806 4838
Edem3 2254 6454
Rnf185 6657 2119

Click HERE to show all gene set members

All member genes
LPS OVA
Amfr 5390 7797
Calr 8166 5149
Canx 6321 1740
Derl1 6433 8377
Derl2 8155 9168
Edem1 -1051 5338
Edem2 5598 9207
Edem3 2254 6454
Engase -6968 894
Ganab 7241 8914
Man1b1 6092 8607
Marchf6 5800 6991
Mlec 7511 8004
Mogs -3423 -2829
Ngly1 7666 7938
Os9 6542 7667
Pdia3 7836 8348
Prkcsh 7664 96
Psmc1 745 -3975
Rad23b 3806 4838
Rnf103 -715 4985
Rnf139 5265 7108
Rnf185 6657 2119
Rnf5 5623 1021
Rps27a -474 -2051
Sel1l -2235 5032
Syvn1 5130 7943
Trim13 -2986 4140
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871
Ubxn1 -2016 -2510
Uggt1 5261 7777
Uggt2 -2714 3827
Vcp 7357 4449



BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM
metric value
setSize 21
pMANOVA 0.000817
p.adjustMANOVA 0.0074
s.dist 0.592
s.LPS 0.359
s.OVA 0.47
p.LPS 0.00442
p.OVA 0.000191




Top 20 genes
Gene LPS OVA
Aldh6a1 7713 9173
Ivd 7446 8648
Dld 6857 8590
Hibadh 6467 7961
Echs1 5490 8280
Bckdhb 6528 6577
Acadsb 6347 6688
Bcat2 6010 6616
Acat1 4056 8168
Slc25a44 4890 6692
Hsd17b10 5142 3197
Mccc2 2532 5837
Bcat1 3777 2384

Click HERE to show all gene set members

All member genes
LPS OVA
Acad8 -946 7028
Acadsb 6347 6688
Acat1 4056 8168
Aldh6a1 7713 9173
Auh -1870 -1832
Bcat1 3777 2384
Bcat2 6010 6616
Bckdha 225 -1149
Bckdhb 6528 6577
Bckdk -3547 -1040
Dbt -1670 7164
Dld 6857 8590
Echs1 5490 8280
Hibadh 6467 7961
Hibch 3400 -65
Hsd17b10 5142 3197
Ivd 7446 8648
Mccc1 -6589 5294
Mccc2 2532 5837
Ppm1k -5211 -6224
Slc25a44 4890 6692



ER QUALITY CONTROL COMPARTMENT ERQC

ER QUALITY CONTROL COMPARTMENT ERQC
metric value
setSize 21
pMANOVA 0.000729
p.adjustMANOVA 0.00686
s.dist 0.59
s.LPS 0.349
s.OVA 0.476
p.LPS 0.00566
p.OVA 0.000157




Top 20 genes
Gene LPS OVA
Derl2 8155 9168
Man1b1 6092 8607
Edem2 5598 9207
Os9 6542 7667
Amfr 5390 7797
Uggt1 5261 7777
Syvn1 5130 7943
Marchf6 5800 6991
Rnf139 5265 7108
Ubc 4469 5871
Edem3 2254 6454
Rnf185 6657 2119
Rnf5 5623 1021

Click HERE to show all gene set members

All member genes
LPS OVA
Amfr 5390 7797
Derl2 8155 9168
Edem1 -1051 5338
Edem2 5598 9207
Edem3 2254 6454
Man1b1 6092 8607
Marchf6 5800 6991
Os9 6542 7667
Rnf103 -715 4985
Rnf139 5265 7108
Rnf185 6657 2119
Rnf5 5623 1021
Rps27a -474 -2051
Sel1l -2235 5032
Syvn1 5130 7943
Trim13 -2986 4140
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871
Uggt1 5261 7777
Uggt2 -2714 3827



SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
metric value
setSize 20
pMANOVA 0.00207
p.adjustMANOVA 0.0142
s.dist 0.582
s.LPS 0.397
s.OVA 0.426
p.LPS 0.00211
p.OVA 0.000974




Top 20 genes
Gene LPS OVA
Acsbg1 7585 9139
Hsd17b12 7580 7845
Acsl4 7696 7303
Acsl6 6008 8414
Elovl1 7422 6273
Hacd2 6470 7159
Elovl4 5811 6542
Acsl3 4247 8897
Elovl2 2596 8770
Acsl1 2698 7510
Acsl5 4882 3721
Elovl5 2615 6088
Elovl6 2843 3664
Hacd3 5842 1132

Click HERE to show all gene set members

All member genes
LPS OVA
Acsbg1 7585 9139
Acsf3 -1804 4006
Acsl1 2698 7510
Acsl3 4247 8897
Acsl4 7696 7303
Acsl5 4882 3721
Acsl6 6008 8414
Elovl1 7422 6273
Elovl2 2596 8770
Elovl4 5811 6542
Elovl5 2615 6088
Elovl6 2843 3664
Elovl7 -8038 -5822
Hacd1 -8674 -5349
Hacd2 6470 7159
Hacd3 5842 1132
Hacd4 -3842 6671
Hsd17b12 7580 7845
Slc27a3 2104 -2371
Tecr 6969 -4005



LDL CLEARANCE

LDL CLEARANCE
metric value
setSize 16
pMANOVA 0.00782
p.adjustMANOVA 0.0351
s.dist 0.57
s.LPS 0.437
s.OVA 0.365
p.LPS 0.00247
p.OVA 0.0115




Top 20 genes
Gene LPS OVA
Lipa 8178 7907
Soat1 6665 8803
Ap2b1 7471 7369
Ap2a2 6935 7060
Npc1 7172 6327
Nceh1 5519 7620
Ap2m1 7740 4084
Cltc 4452 6224
Ap2a1 6068 3850
Lsr 737 3259

Click HERE to show all gene set members

All member genes
LPS OVA
Ap2a1 6068 3850
Ap2a2 6935 7060
Ap2b1 7471 7369
Ap2m1 7740 4084
Ap2s1 -3446 -4267
Clta 3532 -54
Cltc 4452 6224
Ldlr 1977 -1163
Ldlrap1 -6068 4836
Lipa 8178 7907
Lsr 737 3259
Nceh1 5519 7620
Npc1 7172 6327
Npc2 1614 -185
Pcsk9 -4130 -1686
Soat1 6665 8803



COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC

COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
metric value
setSize 44
pMANOVA 8.88e-08
p.adjustMANOVA 4.54e-06
s.dist 0.567
s.LPS 0.493
s.OVA 0.28
p.LPS 1.48e-08
p.OVA 0.00131




Top 20 genes
Gene LPS OVA
Tubb2b 7453 8823
Capza2 7653 8008
Dctn4 7128 8231
Rab6a 6535 8210
Rab3gap1 6030 7125
Dctn6 6420 6162
Pla2g4a 4614 8558
Tubb2a 8077 4592
Tuba1b 7821 4723
Actr1a 7338 4720
Galnt1 4201 8153
Dync1i1 5720 5691
Dctn1 6145 4917
Capza1 7204 4152
Pla2g6 5442 5370
Rab6b 5264 5274
Tuba4a 7159 3675
Tubb4a 7466 3029
Rab18 6492 3311
Galnt2 2740 6703

Click HERE to show all gene set members

All member genes
LPS OVA
Actr10 2944 5266
Actr1a 7338 4720
Agpat3 1972 7995
Bicd1 -3966 1922
Bicd2 -359 6315
Capza1 7204 4152
Capza2 7653 8008
Capzb 5170 2822
Dctn1 6145 4917
Dctn2 3292 2492
Dctn3 326 -3090
Dctn4 7128 8231
Dctn5 5395 -1094
Dctn6 6420 6162
Dync1h1 1330 2837
Dync1i1 5720 5691
Dync1i2 -3869 -3708
Dync1li1 2606 -771
Dync1li2 -3512 711
Dynll1 3587 -3371
Dynll2 -1873 -1447
Galnt1 4201 8153
Galnt2 2740 6703
Pafah1b1 2567 5226
Pafah1b2 2277 -2438
Pafah1b3 2866 -4344
Pla2g4a 4614 8558
Pla2g6 5442 5370
Rab18 6492 3311
Rab3gap1 6030 7125
Rab3gap2 2176 3917
Rab6a 6535 8210
Rab6b 5264 5274
Tuba1a 7018 1821
Tuba1b 7821 4723
Tuba1c 4454 -1802
Tuba4a 7159 3675
Tuba8 -5535 -1623
Tubb2a 8077 4592
Tubb2b 7453 8823
Tubb3 5803 -2348
Tubb4a 7466 3029
Tubb4b 7571 2010
Tubb6 1793 -4650



GLYCOSPHINGOLIPID METABOLISM

GLYCOSPHINGOLIPID METABOLISM
metric value
setSize 38
pMANOVA 1.57e-05
p.adjustMANOVA 0.000324
s.dist 0.566
s.LPS 0.407
s.OVA 0.394
p.LPS 1.44e-05
p.OVA 2.58e-05




Top 20 genes
Gene LPS OVA
B3galnt1 7997 9137
Galc 7161 8790
Arsa 6691 8889
B4galnt1 7700 7388
Asah1 6582 8559
Arsb 6678 8194
Esyt1 6538 8359
Gba2 6740 7374
Neu4 5713 8437
Ugt8a 7397 6298
Gla 4877 9109
Gltp 6269 5958
Neu1 6663 5369
Neu2 6963 5097
Psap 5602 6261
Gm2a 6044 4988
Gba 5517 3984
Neu3 2465 8852
Hexb 4271 4683
Ugcg 2948 6251

Click HERE to show all gene set members

All member genes
LPS OVA
Arsa 6691 8889
Arsb 6678 8194
Arsg -3282 3763
Arsj -2288 -3265
Arsk 1756 2984
Asah1 6582 8559
Asah2 -2405 -753
B3galnt1 7997 9137
B4galnt1 7700 7388
Cerk -4509 5185
Cptp -910 5038
Ctsa -2112 -3045
Esyt1 6538 8359
Esyt2 -6814 800
Esyt3 -116 -7277
Galc 7161 8790
Gba 5517 3984
Gba2 6740 7374
Gla 4877 9109
Glb1 2185 1248
Glb1l 547 4438
Gltp 6269 5958
Gm2a 6044 4988
Hexa 5594 -480
Hexb 4271 4683
Neu1 6663 5369
Neu2 6963 5097
Neu3 2465 8852
Neu4 5713 8437
Psap 5602 6261
Smpd1 6829 2467
Smpd2 -2794 -411
Smpd3 4171 2157
Smpd4 -2111 -3325
Sumf1 2195 672
Sumf2 2160 -146
Ugcg 2948 6251
Ugt8a 7397 6298



RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY
metric value
setSize 11
pMANOVA 0.0428
p.adjustMANOVA 0.126
s.dist 0.554
s.LPS 0.424
s.OVA 0.357
p.LPS 0.0149
p.OVA 0.0403




Top 20 genes
Gene LPS OVA
Fundc1 6660 8373
Atg12 6419 7411
Pgam5 2228 7190
Csnk2b 5028 3178
Src 2534 5622
Ulk1 4329 2722
Atg5 1468 7547
Map1lc3b 3512 2819

Click HERE to show all gene set members

All member genes
LPS OVA
Atg12 6419 7411
Atg5 1468 7547
Csnk2a1 -2718 -318
Csnk2a2 5837 -486
Csnk2b 5028 3178
Fundc1 6660 8373
Map1lc3a 853 -3573
Map1lc3b 3512 2819
Pgam5 2228 7190
Src 2534 5622
Ulk1 4329 2722



SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
metric value
setSize 10
pMANOVA 0.0623
p.adjustMANOVA 0.161
s.dist 0.548
s.LPS 0.414
s.OVA 0.359
p.LPS 0.0235
p.OVA 0.0491




Top 20 genes
Gene LPS OVA
Itpk1 7870 9023
Ip6k3 7038 5495
Nudt11 7746 3969
Nudt4 3934 6701
Ip6k1 2804 6168
Nudt3 2724 91

Click HERE to show all gene set members

All member genes
LPS OVA
Ip6k1 2804 6168
Ip6k3 7038 5495
Ippk 604 -2211
Itpk1 7870 9023
Nudt10 5295 -2917
Nudt11 7746 3969
Nudt3 2724 91
Nudt4 3934 6701
Ppip5k1 -2530 4251
Ppip5k2 -3505 6431



ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
metric value
setSize 10
pMANOVA 0.0439
p.adjustMANOVA 0.129
s.dist 0.548
s.LPS 0.302
s.OVA 0.457
p.LPS 0.0979
p.OVA 0.0124




Top 20 genes
Gene LPS OVA
Folh1 7926 9236
Slc25a12 6009 7235
Asns 5433 7781
Got2 6799 5913
Got1 4473 6346

Click HERE to show all gene set members

All member genes
LPS OVA
Asns 5433 7781
Aspa -4660 6617
Aspg -6198 1018
Folh1 7926 9236
Got1 4473 6346
Got2 6799 5913
Naalad2 5764 -1293
Nat8l 1218 -149
Slc25a12 6009 7235
Slc25a13 -4518 2785



TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
metric value
setSize 13
pMANOVA 0.000265
p.adjustMANOVA 0.00324
s.dist 0.539
s.LPS 0.535
s.OVA 0.0688
p.LPS 0.000836
p.OVA 0.668




Top 20 genes
Gene LPS OVA
Tubb2b 7453 8823
Tubb2a 8077 4592
Tuba1b 7821 4723
Tuba4a 7159 3675
Tubb4a 7466 3029
Gja1 5067 3858
Tubb4b 7571 2010
Tuba1a 7018 1821

Click HERE to show all gene set members

All member genes
LPS OVA
Gja1 5067 3858
Gjb2 -8815 -6999
Tuba1a 7018 1821
Tuba1b 7821 4723
Tuba1c 4454 -1802
Tuba4a 7159 3675
Tuba8 -5535 -1623
Tubb2a 8077 4592
Tubb2b 7453 8823
Tubb3 5803 -2348
Tubb4a 7466 3029
Tubb4b 7571 2010
Tubb6 1793 -4650



TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX

TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
metric value
setSize 12
pMANOVA 0.0382
p.adjustMANOVA 0.117
s.dist 0.537
s.LPS 0.417
s.OVA 0.339
p.LPS 0.0124
p.OVA 0.042




Top 20 genes
Gene LPS OVA
Chmp3 7058 8270
Uvrag 5872 6872
Chmp2b 6302 4487
Chmp7 7102 3885
Pik3c3 3968 6884
Chmp4b 6000 4385
Pik3r4 2139 6151
Map1lc3b 3512 2819
Chmp6 1707 2683

Click HERE to show all gene set members

All member genes
LPS OVA
Becn1 6094 -943
Chmp2a -2622 -2847
Chmp2b 6302 4487
Chmp3 7058 8270
Chmp4b 6000 4385
Chmp4c -8459 -382
Chmp6 1707 2683
Chmp7 7102 3885
Map1lc3b 3512 2819
Pik3c3 3968 6884
Pik3r4 2139 6151
Uvrag 5872 6872



KERATAN SULFATE BIOSYNTHESIS

KERATAN SULFATE BIOSYNTHESIS
metric value
setSize 24
pMANOVA 5.54e-05
p.adjustMANOVA 0.000932
s.dist 0.536
s.LPS 0.496
s.OVA 0.201
p.LPS 2.55e-05
p.OVA 0.088




Top 20 genes
Gene LPS OVA
B4galt4 8080 9233
B4gat1 7815 6654
Chst2 6861 7316
B3gnt2 6411 7769
St3gal4 5374 8530
Prelp 8253 3935
B4galt2 7004 4079
St3gal2 4770 5945
Chst1 5694 3430
Fmod 3989 4065
St3gal3 1858 8282
Chst5 1475 3783
B4galt3 2015 2089
Slc35d2 3245 879
B4galt5 1624 1346
B3gnt7 2802 561

Click HERE to show all gene set members

All member genes
LPS OVA
Acan 5223 -1262
B3gnt2 6411 7769
B3gnt4 4142 -2699
B3gnt7 2802 561
B4galt1 7157 -2640
B4galt2 7004 4079
B4galt3 2015 2089
B4galt4 8080 9233
B4galt5 1624 1346
B4galt6 4152 -2752
B4gat1 7815 6654
Chst1 5694 3430
Chst2 6861 7316
Chst5 1475 3783
Fmod 3989 4065
Lum 3364 -3694
Ogn -1916 -1340
Prelp 8253 3935
Slc35d2 3245 879
St3gal1 2408 -236
St3gal2 4770 5945
St3gal3 1858 8282
St3gal4 5374 8530
St3gal6 -7804 -7654



INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1

INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
metric value
setSize 13
pMANOVA 0.0151
p.adjustMANOVA 0.0576
s.dist 0.533
s.LPS 0.267
s.OVA 0.462
p.LPS 0.0962
p.OVA 0.00395




Top 20 genes
Gene LPS OVA
Tfdp1 8201 8324
Prim1 5135 7381
Pola2 5131 7073
Prim2 4273 8464
Ppp2ca 6291 5122
Ppp2r1a 5549 4597
Rb1 1665 7157
E2f1 1156 8445
Tfdp2 351 946

Click HERE to show all gene set members

All member genes
LPS OVA
E2f1 1156 8445
Pola1 -4348 5654
Pola2 5131 7073
Ppp2ca 6291 5122
Ppp2cb -500 -1854
Ppp2r1a 5549 4597
Ppp2r1b -4728 3962
Ppp2r3d -3324 -5571
Prim1 5135 7381
Prim2 4273 8464
Rb1 1665 7157
Tfdp1 8201 8324
Tfdp2 351 946



THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS

THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
metric value
setSize 27
pMANOVA 0.000741
p.adjustMANOVA 0.00692
s.dist 0.529
s.LPS 0.327
s.OVA 0.416
p.LPS 0.00327
p.OVA 0.000185




Top 20 genes
Gene LPS OVA
Ap1m1 7255 8999
Elmo1 7267 8749
Ap2b1 7471 7369
Ap1b1 6687 7892
Atp6v1h 6910 7530
Rac1 5981 8506
Pak2 5854 8623
Ap2a2 6935 7060
Fyn 4377 8562
Arf1 6828 4833
Ap2m1 7740 4084
Dock2 4144 6534
Ap2a1 6068 3850
Hck 3098 6685
Ap1m2 3485 5571
Ap1s1 5139 3718
Ap1s2 6206 2182
Pacs1 1480 4480
Lck 3264 1840
Ap1g1 1095 3836

Click HERE to show all gene set members

All member genes
LPS OVA
Ap1b1 6687 7892
Ap1g1 1095 3836
Ap1m1 7255 8999
Ap1m2 3485 5571
Ap1s1 5139 3718
Ap1s2 6206 2182
Ap1s3 -8420 -7032
Ap2a1 6068 3850
Ap2a2 6935 7060
Ap2b1 7471 7369
Ap2m1 7740 4084
Ap2s1 -3446 -4267
Arf1 6828 4833
Atp6v1h 6910 7530
B2m -7075 -114
Dock2 4144 6534
Elmo1 7267 8749
Fyn 4377 8562
H2-D1 -5004 -1996
H2-Q10 -6927 -2358
H2-Q2 -2892 7888
H2-Q7 -7706 40
Hck 3098 6685
Lck 3264 1840
Pacs1 1480 4480
Pak2 5854 8623
Rac1 5981 8506



WNT LIGAND BIOGENESIS AND TRAFFICKING

WNT LIGAND BIOGENESIS AND TRAFFICKING
metric value
setSize 21
pMANOVA 0.00471
p.adjustMANOVA 0.0246
s.dist 0.525
s.LPS 0.397
s.OVA 0.343
p.LPS 0.00162
p.OVA 0.00646




Top 20 genes
Gene LPS OVA
Wls 8022 8310
Wnt9b 7199 9223
Vps35 6664 8865
Wnt11 8278 6743
Vps26a 4642 8130
Wnt9a 3748 8473
Wnt3 3461 5883
Wnt2 2424 5758
Snx3 6972 1957
Wnt7b 4567 2286
Wnt2b 2443 3971
Wnt16 1053 4013
Vps29 4541 898
Porcn 763 4486
Wnt10a 2463 617
Wnt7a 2230 447
Tmed5 169 1726
Wnt5b 160 1739

Click HERE to show all gene set members

All member genes
LPS OVA
Porcn 763 4486
Snx3 6972 1957
Tmed5 169 1726
Vps26a 4642 8130
Vps29 4541 898
Vps35 6664 8865
Wls 8022 8310
Wnt10a 2463 617
Wnt11 8278 6743
Wnt16 1053 4013
Wnt2 2424 5758
Wnt2b 2443 3971
Wnt3 3461 5883
Wnt4 1499 -4212
Wnt5a -5602 -2249
Wnt5b 160 1739
Wnt6 -1583 -2353
Wnt7a 2230 447
Wnt7b 4567 2286
Wnt9a 3748 8473
Wnt9b 7199 9223



GLYCOGEN SYNTHESIS

GLYCOGEN SYNTHESIS
metric value
setSize 14
pMANOVA 0.0142
p.adjustMANOVA 0.0555
s.dist 0.522
s.LPS 0.449
s.OVA 0.266
p.LPS 0.00363
p.OVA 0.0849




Top 20 genes
Gene LPS OVA
Pgm1 8264 9024
Ugp2 8040 8940
Gbe1 7258 8707
Epm2a 5058 6792
Ubc 4469 5871
Gyg 7658 2365
Gys1 1862 7836
Ppp1r3c 2860 3244
Pgm2 6596 1172
Nhlrc1 6890 121

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All member genes
LPS OVA
Epm2a 5058 6792
Gbe1 7258 8707
Gyg 7658 2365
Gys1 1862 7836
Nhlrc1 6890 121
Pgm1 8264 9024
Pgm2 6596 1172
Pgm2l1 -2554 -1763
Ppp1r3c 2860 3244
Rps27a -474 -2051
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871
Ugp2 8040 8940



GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
metric value
setSize 12
pMANOVA 0.0209
p.adjustMANOVA 0.0739
s.dist 0.507
s.LPS 0.454
s.OVA 0.225
p.LPS 0.00645
p.OVA 0.177




Top 20 genes
Gene LPS OVA
Gbe1 7258 8707
Epm2a 5058 6792
G6pc3 6399 4205
Ubc 4469 5871
Gaa 7484 3116
Gyg 7658 2365
Gys1 1862 7836
Ppp1r3c 2860 3244
Nhlrc1 6890 121

Click HERE to show all gene set members

All member genes
LPS OVA
Epm2a 5058 6792
G6pc3 6399 4205
Gaa 7484 3116
Gbe1 7258 8707
Gyg 7658 2365
Gys1 1862 7836
Nhlrc1 6890 121
Ppp1r3c 2860 3244
Rps27a -474 -2051
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871



CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE

CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
metric value
setSize 49
pMANOVA 1.08e-05
p.adjustMANOVA 0.000251
s.dist 0.506
s.LPS 0.37
s.OVA 0.345
p.LPS 7.34e-06
p.OVA 2.87e-05




Top 20 genes
Gene LPS OVA
Rp2 7314 9069
Exoc3 7715 8123
Arf4 7960 7361
Lztfl1 6459 8899
Mkks 7976 7175
Exoc7 6520 8235
Tcp1 6593 8066
Mchr1 7206 7350
Arl6 6927 7336
Cct3 7101 6548
Pde6d 7272 6093
Bbs10 7829 5566
Cct5 7277 5981
Rab3ip 6180 7022
Unc119b 5251 8034
Bbs1 5886 7036
Ttc8 6129 5688
Cct4 6208 5466
Bbs7 4485 6357
Cys1 6069 4242

Click HERE to show all gene set members

All member genes
LPS OVA
Arf4 7960 7361
Arl13b 2450 2786
Arl3 518 -2261
Arl6 6927 7336
Asap1 -601 21
Bbip1 1822 -684
Bbs1 5886 7036
Bbs10 7829 5566
Bbs12 -5740 -115
Bbs2 2145 306
Bbs4 1644 5486
Bbs5 -5655 -4831
Bbs7 4485 6357
Bbs9 7185 -196
Cct2 3803 3757
Cct3 7101 6548
Cct4 6208 5466
Cct5 7277 5981
Cct8 6441 3130
Cnga4 -225 -1799
Cngb1 -9080 -8022
Cys1 6069 4242
Exoc1 2792 4011
Exoc2 -2070 1202
Exoc3 7715 8123
Exoc4 6052 2451
Exoc5 -5528 8344
Exoc6 1636 86
Exoc7 6520 8235
Exoc8 2545 1066
Gbf1 3341 5696
Inpp5e -2184 44
Lztfl1 6459 8899
Mchr1 7206 7350
Mkks 7976 7175
Nphp3 -3914 -3640
Pde6d 7272 6093
Pkd1 -6215 -2849
Pkd2 -4406 -195
Rab11a -152 4123
Rab11fip3 1296 6174
Rab3ip 6180 7022
Rab8a 5768 2908
Rp2 7314 9069
Smo 5017 5074
Sstr3 -5327 3299
Tcp1 6593 8066
Ttc8 6129 5688
Unc119b 5251 8034



INSULIN PROCESSING

INSULIN PROCESSING
metric value
setSize 24
pMANOVA 0.00392
p.adjustMANOVA 0.0218
s.dist 0.504
s.LPS 0.347
s.OVA 0.366
p.LPS 0.00326
p.OVA 0.00194




Top 20 genes
Gene LPS OVA
Pcsk1 7855 8939
Exoc3 7715 8123
Ero1a 6685 8249
Exoc7 6520 8235
Pcsk2 6282 6727
Cpe 6473 6242
Myrip 3917 8690
Slc30a7 4400 6889
Slc30a5 3545 6790
Exoc4 6052 2451
Exoc1 2792 4011
Ero1b 2942 923
Exoc8 2545 1066
Exoc6 1636 86

Click HERE to show all gene set members

All member genes
LPS OVA
Cpe 6473 6242
Ero1a 6685 8249
Ero1b 2942 923
Exoc1 2792 4011
Exoc2 -2070 1202
Exoc3 7715 8123
Exoc4 6052 2451
Exoc5 -5528 8344
Exoc6 1636 86
Exoc7 6520 8235
Exoc8 2545 1066
Kif5a -395 5645
Kif5b -8074 -2093
Kif5c -5658 3803
Myo5a -78 5779
Myrip 3917 8690
Pcsk1 7855 8939
Pcsk2 6282 6727
Rab27a -2295 -33
Slc30a5 3545 6790
Slc30a6 5531 -370
Slc30a7 4400 6889
Stx1a 7219 -4211
Vamp2 4671 -5454



SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
metric value
setSize 11
pMANOVA 0.00217
p.adjustMANOVA 0.0146
s.dist 0.502
s.LPS 0.0586
s.OVA 0.498
p.LPS 0.736
p.OVA 0.0042




Top 20 genes
Gene LPS OVA
Fig4 6197 9162
Vac14 6536 5884
Pik3c3 3968 6884
Pik3r4 2139 6151
Mtmr4 322 4777
Mtmr7 171 5114

Click HERE to show all gene set members

All member genes
LPS OVA
Fig4 6197 9162
Mtm1 -572 5736
Mtmr2 -3342 5999
Mtmr4 322 4777
Mtmr7 171 5114
Mtmr9 -4429 -1093
Pik3c2a -2931 6798
Pik3c3 3968 6884
Pik3r4 2139 6151
Pikfyve -6999 -1351
Vac14 6536 5884



GLYCOGEN METABOLISM

GLYCOGEN METABOLISM
metric value
setSize 25
pMANOVA 0.00168
p.adjustMANOVA 0.0126
s.dist 0.499
s.LPS 0.413
s.OVA 0.28
p.LPS 0.000354
p.OVA 0.0152




Top 20 genes
Gene LPS OVA
Pgm1 8264 9024
Ugp2 8040 8940
Gbe1 7258 8707
Pygm 6817 9147
Pygb 7321 6289
Phkb 5254 8679
Epm2a 5058 6792
Ubc 4469 5871
Phka1 3643 7003
Gaa 7484 3116
Gyg 7658 2365
Gys1 1862 7836
Ppp1r3c 2860 3244
Pgm2 6596 1172
Agl 1023 5048
Phkg2 1343 1262
Phkg1 1365 1145
Nhlrc1 6890 121

Click HERE to show all gene set members

All member genes
LPS OVA
Agl 1023 5048
Calm1 447 -3048
Epm2a 5058 6792
Gaa 7484 3116
Gbe1 7258 8707
Gyg 7658 2365
Gys1 1862 7836
Nhlrc1 6890 121
Pgm1 8264 9024
Pgm2 6596 1172
Pgm2l1 -2554 -1763
Phka1 3643 7003
Phka2 -1531 282
Phkb 5254 8679
Phkg1 1365 1145
Phkg2 1343 1262
Ppp1r3c 2860 3244
Pygb 7321 6289
Pygl -2579 -4086
Pygm 6817 9147
Rps27a -474 -2051
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871
Ugp2 8040 8940



FATTY ACYL COA BIOSYNTHESIS

FATTY ACYL COA BIOSYNTHESIS
metric value
setSize 32
pMANOVA 0.000726
p.adjustMANOVA 0.00686
s.dist 0.498
s.LPS 0.343
s.OVA 0.362
p.LPS 0.000781
p.OVA 4e-04




Top 20 genes
Gene LPS OVA
Ppt1 7985 9079
Acsbg1 7585 9139
Hsd17b12 7580 7845
Rpp14 6558 8924
Acsl4 7696 7303
Acsl6 6008 8414
Elovl1 7422 6273
Hacd2 6470 7159
Elovl4 5811 6542
Acsl3 4247 8897
Scd2 5984 4886
Scd1 5493 4643
Elovl2 2596 8770
Acsl1 2698 7510
Acsl5 4882 3721
Elovl5 2615 6088
Fasn 3298 4731
Elovl6 2843 3664
Hacd3 5842 1132
Acly 1342 4759

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All member genes
LPS OVA
Acaca -3286 3621
Acly 1342 4759
Acsbg1 7585 9139
Acsf3 -1804 4006
Acsl1 2698 7510
Acsl3 4247 8897
Acsl4 7696 7303
Acsl5 4882 3721
Acsl6 6008 8414
Cbr4 -3146 6048
Elovl1 7422 6273
Elovl2 2596 8770
Elovl4 5811 6542
Elovl5 2615 6088
Elovl6 2843 3664
Elovl7 -8038 -5822
Fasn 3298 4731
H2-Ke6 -4702 -6581
Hacd1 -8674 -5349
Hacd2 6470 7159
Hacd3 5842 1132
Hacd4 -3842 6671
Hsd17b12 7580 7845
Morc2a -6251 -4901
Ppt1 7985 9079
Ppt2 1955 -1263
Rpp14 6558 8924
Scd1 5493 4643
Scd2 5984 4886
Slc25a1 6237 -647
Slc27a3 2104 -2371
Tecr 6969 -4005



COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
metric value
setSize 26
pMANOVA 1.99e-05
p.adjustMANOVA 0.000398
s.dist 0.498
s.LPS 0.477
s.OVA 0.142
p.LPS 2.52e-05
p.OVA 0.212




Top 20 genes
Gene LPS OVA
Cct6a 8085 8933
Tubb2b 7453 8823
Tcp1 6593 8066
Cct3 7101 6548
Cct5 7277 5981
Tubb2a 8077 4592
Tuba1b 7821 4723
Cct4 6208 5466
Tuba4a 7159 3675
Tubb4a 7466 3029
Cct8 6441 3130
Cct7 4809 3665
Tubb4b 7571 2010
Cct2 3803 3757
Tuba1a 7018 1821
Pfdn4 4498 2400
Vbp1 3155 1445

Click HERE to show all gene set members

All member genes
LPS OVA
Actb -8328 -7798
Cct2 3803 3757
Cct3 7101 6548
Cct4 6208 5466
Cct5 7277 5981
Cct6a 8085 8933
Cct7 4809 3665
Cct8 6441 3130
Pfdn1 569 -697
Pfdn2 -4877 -5680
Pfdn4 4498 2400
Pfdn5 -3168 -2135
Pfdn6 -3777 -4618
Tcp1 6593 8066
Tuba1a 7018 1821
Tuba1b 7821 4723
Tuba1c 4454 -1802
Tuba4a 7159 3675
Tuba8 -5535 -1623
Tubb2a 8077 4592
Tubb2b 7453 8823
Tubb3 5803 -2348
Tubb4a 7466 3029
Tubb4b 7571 2010
Tubb6 1793 -4650
Vbp1 3155 1445



KERATAN SULFATE KERATIN METABOLISM

KERATAN SULFATE KERATIN METABOLISM
metric value
setSize 30
pMANOVA 3.75e-05
p.adjustMANOVA 0.000668
s.dist 0.498
s.LPS 0.457
s.OVA 0.197
p.LPS 1.46e-05
p.OVA 0.062




Top 20 genes
Gene LPS OVA
B4galt4 8080 9233
B4gat1 7815 6654
Chst2 6861 7316
B3gnt2 6411 7769
St3gal4 5374 8530
Prelp 8253 3935
Gns 4623 6215
B4galt2 7004 4079
St3gal2 4770 5945
Hexb 4271 4683
Chst1 5694 3430
Fmod 3989 4065
St3gal3 1858 8282
Chst5 1475 3783
B4galt3 2015 2089
Slc35d2 3245 879
Glb1 2185 1248
Glb1l 547 4438
B4galt5 1624 1346
B3gnt7 2802 561

Click HERE to show all gene set members

All member genes
LPS OVA
Acan 5223 -1262
B3gnt2 6411 7769
B3gnt4 4142 -2699
B3gnt7 2802 561
B4galt1 7157 -2640
B4galt2 7004 4079
B4galt3 2015 2089
B4galt4 8080 9233
B4galt5 1624 1346
B4galt6 4152 -2752
B4gat1 7815 6654
Chst1 5694 3430
Chst2 6861 7316
Chst5 1475 3783
Fmod 3989 4065
Galns -4047 -3360
Glb1 2185 1248
Glb1l 547 4438
Gns 4623 6215
Hexa 5594 -480
Hexb 4271 4683
Lum 3364 -3694
Ogn -1916 -1340
Prelp 8253 3935
Slc35d2 3245 879
St3gal1 2408 -236
St3gal2 4770 5945
St3gal3 1858 8282
St3gal4 5374 8530
St3gal6 -7804 -7654



SPHINGOLIPID METABOLISM

SPHINGOLIPID METABOLISM
metric value
setSize 80
pMANOVA 6.31e-09
p.adjustMANOVA 4.13e-07
s.dist 0.495
s.LPS 0.301
s.OVA 0.393
p.LPS 3.32e-06
p.OVA 1.22e-09




Top 20 genes
Gene LPS OVA
B3galnt1 7997 9137
Sptlc1 7604 8759
Galc 7161 8790
Arsa 6691 8889
Ormdl1 6336 9141
Degs2 7869 7285
B4galnt1 7700 7388
Asah1 6582 8559
Arsb 6678 8194
Esyt1 6538 8359
Gba2 6740 7374
Fa2h 6118 8042
Neu4 5713 8437
Prkd1 6931 6952
Ugt8a 7397 6298
Degs1 5708 7862
Gla 4877 9109
Plpp1 6448 6764
Ormdl2 5147 7848
Gltp 6269 5958

Click HERE to show all gene set members

All member genes
LPS OVA
Acer2 -9047 -1937
Acer3 -3489 -3224
Aldh3a2 -2391 6593
Aldh3b1 -1320 -2873
Arsa 6691 8889
Arsb 6678 8194
Arsg -3282 3763
Arsj -2288 -3265
Arsk 1756 2984
Asah1 6582 8559
Asah2 -2405 -753
B3galnt1 7997 9137
B4galnt1 7700 7388
Cerk -4509 5185
Cers1 2338 5816
Cers2 4862 3089
Cers4 -6510 -6968
Cers5 -2155 5881
Cers6 5640 4357
Cert1 -2944 5959
Cptp -910 5038
Csnk1g2 2074 5674
Ctsa -2112 -3045
Degs1 5708 7862
Degs2 7869 7285
Esyt1 6538 8359
Esyt2 -6814 800
Esyt3 -116 -7277
Fa2h 6118 8042
Galc 7161 8790
Gba 5517 3984
Gba2 6740 7374
Gla 4877 9109
Glb1 2185 1248
Glb1l 547 4438
Gltp 6269 5958
Gm2a 6044 4988
Hexa 5594 -480
Hexb 4271 4683
Kdsr -2044 -2785
Neu1 6663 5369
Neu2 6963 5097
Neu3 2465 8852
Neu4 5713 8437
Ormdl1 6336 9141
Ormdl2 5147 7848
Ormdl3 3620 4925
Osbp 441 7029
Plpp1 6448 6764
Plpp2 3225 1339
Plpp3 2824 7864
Ppm1l -4939 3758
Prkd1 6931 6952
Prkd2 -58 2895
Prkd3 -1886 6249
Psap 5602 6261
Samd8 -8924 -5739
Sgms1 -3028 7773
Sgms2 4146 5962
Sgpl1 -2913 5081
Sgpp1 3051 5717
Sgpp2 3112 5528
Smpd1 6829 2467
Smpd2 -2794 -411
Smpd3 4171 2157
Smpd4 -2111 -3325
Sphk1 4713 4743
Sphk2 1736 -2002
Spns2 823 2442
Sptlc1 7604 8759
Sptlc2 -7168 4606
Sptlc3 6251 4160
Sptssa 4220 7189
Sptssb 2120 3120
Sumf1 2195 672
Sumf2 2160 -146
Ugcg 2948 6251
Ugt8a 7397 6298
Vapa 3049 -2515
Vapb 5543 4019



CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
metric value
setSize 11
pMANOVA 0.0559
p.adjustMANOVA 0.15
s.dist 0.49
s.LPS 0.418
s.OVA 0.257
p.LPS 0.0164
p.OVA 0.14




Top 20 genes
Gene LPS OVA
Rac1 5981 8506
Pak2 5854 8623
Pak1 6328 7338
Fyn 4377 8562
Cdc42 3614 4269
Vav1 1289 6483
Lck 3264 1840
Cd86 6390 360

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All member genes
LPS OVA
Cd80 -4653 -7617
Cd86 6390 360
Cdc42 3614 4269
Fyn 4377 8562
Grb2 -446 -1867
Lck 3264 1840
Pak1 6328 7338
Pak2 5854 8623
Pak3 3559 -5644
Rac1 5981 8506
Vav1 1289 6483



IRE1ALPHA ACTIVATES CHAPERONES

IRE1ALPHA ACTIVATES CHAPERONES
metric value
setSize 50
pMANOVA 1.14e-05
p.adjustMANOVA 0.000258
s.dist 0.489
s.LPS 0.384
s.OVA 0.304
p.LPS 2.69e-06
p.OVA 0.000205




Top 20 genes
Gene LPS OVA
Hspa5 8251 9072
Xbp1 8203 8916
Dnajc3 8287 8715
Pdia6 8295 8674
Atp6v0d1 7538 8656
Tpp1 8306 7675
Gfpt1 7006 7359
Srpr 6242 8113
Cxxc1 5145 8766
Syvn1 5130 7943
Ppp2r5b 5718 6651
Dnajb11 7501 4823
Dnajb9 7002 5123
Serp1 4314 8196
Srprb 7639 4327
Fkbp14 3723 8877
Dctn1 6145 4917
Hyou1 6114 4937
Ssr1 5225 4052
Gsk3a 4720 4020

Click HERE to show all gene set members

All member genes
LPS OVA
Acadvl -5432 -3860
Add1 4785 3833
Arfgap1 -626 -6796
Atp6v0d1 7538 8656
Ctdsp2 -495 5793
Cul7 -174 -7166
Cxxc1 5145 8766
Dctn1 6145 4917
Ddx11 -7 2096
Dnajb11 7501 4823
Dnajb9 7002 5123
Dnajc3 8287 8715
Edem1 -1051 5338
Ern1 -1065 5813
Extl1 -3790 -874
Extl2 1784 4004
Extl3 128 3895
Fkbp14 3723 8877
Gfpt1 7006 7359
Gosr2 4947 3103
Gsk3a 4720 4020
Hdgf 2590 -1680
Hspa5 8251 9072
Hyou1 6114 4937
Kdelr3 6034 -5755
Klhdc3 3571 363
Lmna 6232 1613
Mydgf -421 -2899
Pdia5 -6692 -3143
Pdia6 8295 8674
Pla2g4b 347 -2448
Ppp2r5b 5718 6651
Preb 6128 -1318
Sec31a 2645 6290
Serp1 4314 8196
Shc1 1313 1269
Srpr 6242 8113
Srprb 7639 4327
Ssr1 5225 4052
Sult1a1 -436 9055
Syvn1 5130 7943
Tatdn2 -2638 3884
Tln1 563 2132
Tpp1 8306 7675
Tspyl2 -19 -786
Wfs1 -2847 -447
Wipi1 -6527 -5539
Xbp1 8203 8916
Yif1a 5577 2627
Zbtb17 1425 2099



CTLA4 INHIBITORY SIGNALING

CTLA4 INHIBITORY SIGNALING
metric value
setSize 20
pMANOVA 0.0116
p.adjustMANOVA 0.048
s.dist 0.487
s.LPS 0.31
s.OVA 0.376
p.LPS 0.0165
p.OVA 0.00359




Top 20 genes
Gene LPS OVA
Ppp2r5d 8125 7956
Ppp2r5c 5693 7367
Ppp2r5b 5718 6651
Fyn 4377 8562
Ptpn11 3739 9203
Ppp2r5e 4528 7330
Ppp2ca 6291 5122
Ppp2r1a 5549 4597
Akt1 2858 6591
Yes1 1961 8566
Src 2534 5622
Lck 3264 1840
Cd86 6390 360
Ppp2r5a 1268 968

Click HERE to show all gene set members

All member genes
LPS OVA
Akt1 2858 6591
Akt2 -860 -504
Akt3 -548 4218
Cd80 -4653 -7617
Cd86 6390 360
Fyn 4377 8562
Lck 3264 1840
Lyn -5269 -2049
Ppp2ca 6291 5122
Ppp2cb -500 -1854
Ppp2r1a 5549 4597
Ppp2r1b -4728 3962
Ppp2r5a 1268 968
Ppp2r5b 5718 6651
Ppp2r5c 5693 7367
Ppp2r5d 8125 7956
Ppp2r5e 4528 7330
Ptpn11 3739 9203
Src 2534 5622
Yes1 1961 8566



SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
metric value
setSize 15
pMANOVA 0.0279
p.adjustMANOVA 0.0924
s.dist 0.487
s.LPS 0.281
s.OVA 0.398
p.LPS 0.0598
p.OVA 0.0076




Top 20 genes
Gene LPS OVA
Fig4 6197 9162
Sacm1l 5903 7665
Pi4k2a 5771 7198
Vac14 6536 5884
Arf1 6828 4833
Pik3c3 3968 6884
Pi4kb 4891 5126
Ocrl 2491 6039
Pik3r4 2139 6151

Click HERE to show all gene set members

All member genes
LPS OVA
Arf1 6828 4833
Arf3 1373 -1712
Fig4 6197 9162
Inpp5e -2184 44
Ocrl 2491 6039
Pi4k2a 5771 7198
Pi4k2b -2585 -2239
Pi4ka -868 74
Pi4kb 4891 5126
Pik3c2a -2931 6798
Pik3c3 3968 6884
Pik3r4 2139 6151
Pikfyve -6999 -1351
Sacm1l 5903 7665
Vac14 6536 5884



SCAVENGING OF HEME FROM PLASMA

SCAVENGING OF HEME FROM PLASMA
metric value
setSize 11
pMANOVA 0.0481
p.adjustMANOVA 0.135
s.dist 0.485
s.LPS -0.234
s.OVA -0.425
p.LPS 0.179
p.OVA 0.0146




Top 20 genes
Gene LPS OVA
Apol7e -7415 -6844
Apol9a -7628 -6576
Jchain -8578 -4981
Hbb-bt -3700 -5451
Hp -391 -6712

Click HERE to show all gene set members

All member genes
LPS OVA
Apoa1 1483 -2810
Apol7e -7415 -6844
Apol8 -1738 1396
Apol9a -7628 -6576
Cd163 -4835 4549
Hba-a1 2099 -5298
Hba-a2 3883 -4206
Hbb-bt -3700 -5451
Hp -391 -6712
Jchain -8578 -4981
Lrp1 -206 2267



WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
metric value
setSize 13
pMANOVA 0.0343
p.adjustMANOVA 0.109
s.dist 0.482
s.LPS 0.415
s.OVA 0.246
p.LPS 0.00962
p.OVA 0.125




Top 20 genes
Gene LPS OVA
Fzd2 8149 7727
Fzd5 6639 8536
Ap2b1 7471 7369
Ap2a2 6935 7060
Ap2m1 7740 4084
Cltc 4452 6224
Ap2a1 6068 3850

Click HERE to show all gene set members

All member genes
LPS OVA
Ap2a1 6068 3850
Ap2a2 6935 7060
Ap2b1 7471 7369
Ap2m1 7740 4084
Ap2s1 -3446 -4267
Clta 3532 -54
Cltb 3103 -3408
Cltc 4452 6224
Fzd2 8149 7727
Fzd5 6639 8536
Ror1 -6512 4468
Ror2 3146 -4163
Wnt5a -5602 -2249



MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
metric value
setSize 10
pMANOVA 0.0286
p.adjustMANOVA 0.0942
s.dist 0.48
s.LPS 0.159
s.OVA 0.453
p.LPS 0.383
p.OVA 0.0132




Top 20 genes
Gene LPS OVA
Rap1b 7961 7714
Rac1 5981 8506
Crkl 5081 7322
Rap1a 1811 5099
Crk 981 6720
Met 1172 3901

Click HERE to show all gene set members

All member genes
LPS OVA
Crk 981 6720
Crkl 5081 7322
Dock7 -7550 -1950
Gab1 -3649 5950
Grb2 -446 -1867
Met 1172 3901
Rac1 5981 8506
Rap1a 1811 5099
Rap1b 7961 7714
Rapgef1 -1579 3754



INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE

INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
metric value
setSize 22
pMANOVA 0.00426
p.adjustMANOVA 0.023
s.dist 0.479
s.LPS 0.407
s.OVA 0.254
p.LPS 0.00096
p.OVA 0.0392




Top 20 genes
Gene LPS OVA
Prnp 7122 8627
Get3 7084 6986
Bag6 5860 7681
App 5559 7605
Serp1 4314 8196
Cyb5a 5046 6101
Emd 4422 6441
Ubl4a 5343 5247
Get1 8023 1980
Hmox1 1069 8479
Sec61g 2188 1296
Caml 497 3896
Stx5a 583 2287

Click HERE to show all gene set members

All member genes
LPS OVA
Aldh3a2 -2391 6593
App 5559 7605
Bag6 5860 7681
Caml 497 3896
Cyb5a 5046 6101
Emd 4422 6441
Get1 8023 1980
Get3 7084 6986
Get4 -937 -2096
Hmox1 1069 8479
Otof -906 -2226
Prnp 7122 8627
Sec61b -1198 -303
Sec61g 2188 1296
Serp1 4314 8196
Sgta 5101 -2913
Stx1a 7219 -4211
Stx5a 583 2287
Ube2j2 -2779 -578
Ubl4a 5343 5247
Vamp2 4671 -5454
Vapa 3049 -2515



ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY
metric value
setSize 13
pMANOVA 0.059
p.adjustMANOVA 0.155
s.dist 0.479
s.LPS 0.3
s.OVA 0.374
p.LPS 0.0611
p.OVA 0.0196




Top 20 genes
Gene LPS OVA
Gnai3 5865 6754
Gnai2 5680 6854
Gnai1 4825 8037
Adcy3 5375 5538
Gnal 4209 3994
Adcy5 3007 5014
Adcy2 4406 3008
Adcy7 2321 1706

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 -7158 3269
Adcy2 4406 3008
Adcy3 5375 5538
Adcy4 6692 -1185
Adcy5 3007 5014
Adcy6 -1992 -2469
Adcy7 2321 1706
Adcy8 -444 7306
Adcy9 -4137 1906
Gnai1 4825 8037
Gnai2 5680 6854
Gnai3 5865 6754
Gnal 4209 3994



SUPPRESSION OF PHAGOSOMAL MATURATION

SUPPRESSION OF PHAGOSOMAL MATURATION
metric value
setSize 12
pMANOVA 0.0615
p.adjustMANOVA 0.16
s.dist 0.478
s.LPS 0.393
s.OVA 0.271
p.LPS 0.0183
p.OVA 0.104




Top 20 genes
Gene LPS OVA
Rab5a 7154 8793
Atp6v1h 6910 7530
Hgs 5302 5800
Ubc 4469 5871
Kpna1 5110 4527
Vps33b 2917 7702
Kpnb1 3075 5559
Rab7 5455 1267
Coro1a 3166 45

Click HERE to show all gene set members

All member genes
LPS OVA
Atp6v1h 6910 7530
Coro1a 3166 45
Hgs 5302 5800
Kpna1 5110 4527
Kpnb1 3075 5559
Rab5a 7154 8793
Rab7 5455 1267
Rps27a -474 -2051
Uba52 -8154 -7789
Ubb 1292 -2095
Ubc 4469 5871
Vps33b 2917 7702



PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE

PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE
metric value
setSize 51
pMANOVA 2.9e-05
p.adjustMANOVA 0.000533
s.dist 0.475
s.LPS 0.328
s.OVA 0.344
p.LPS 5.12e-05
p.OVA 2.16e-05




Top 20 genes
Gene LPS OVA
Fh1 7863 9041
Idh3a 7936 8737
Me1 7753 8870
Idh2 8195 7982
Pdha1 7271 8104
Dld 6857 8590
Pdp1 7237 8088
Sucla2 6879 7731
Idh3b 6611 7636
Suclg2 5299 8528
Rxra 5778 7419
Pdk3 5018 8443
Aco2 4696 8516
Dlst 6427 6200
Sdha 3974 6855
Sdhd 5042 4956
Adhfe1 2849 8258
Idh3g 4268 4953
Cs 3810 5375
Ogdh 3630 4629

Click HERE to show all gene set members

All member genes
LPS OVA
Aco2 4696 8516
Adhfe1 2849 8258
Bsg -1053 -4756
Cs 3810 5375
D2hgdh -971 -1242
Dlat 65 -613
Dld 6857 8590
Dlst 6427 6200
Fahd1 1716 -3995
Fh1 7863 9041
Glo1 5464 434
Gstz1 -2135 -3058
Hagh 5562 1449
Idh2 8195 7982
Idh3a 7936 8737
Idh3b 6611 7636
Idh3g 4268 4953
L2hgdh -450 3573
Ldha 5481 -680
Ldhb 2576 4182
Mdh2 5287 2235
Me1 7753 8870
Me2 -3379 6182
Me3 -4810 -981
Mpc1 2430 2893
Mpc2 -400 3240
Nnt 3338 3242
Ogdh 3630 4629
Pdha1 7271 8104
Pdhb 2060 5160
Pdhx 686 6231
Pdk1 3253 -4262
Pdk2 2226 5944
Pdk3 5018 8443
Pdk4 -1948 2105
Pdp1 7237 8088
Pdp2 -7052 -4444
Pdpr -5544 4528
Ppard -2574 2847
Rxra 5778 7419
Sdha 3974 6855
Sdhb 2150 1639
Sdhc 1187 1343
Sdhd 5042 4956
Slc16a1 -8727 -5307
Slc16a3 -4889 2290
Slc16a8 -903 -1456
Sucla2 6879 7731
Suclg1 3531 978
Suclg2 5299 8528
Vdac1 4917 2792



HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR

HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
metric value
setSize 48
pMANOVA 5.18e-10
p.adjustMANOVA 5.08e-08
s.dist 0.473
s.LPS 0.465
s.OVA 0.0873
p.LPS 2.45e-08
p.OVA 0.295




Top 20 genes
Gene LPS OVA
Tubb2b 7453 8823
Capza2 7653 8008
Hspa2 8226 7167
Dctn4 7128 8231
Fkbp5 5945 8602
Hspa1b 8108 5703
Dnaja2 7931 5634
Dctn6 6420 6162
Tubb2a 8077 4592
Tuba1b 7821 4723
Actr1a 7338 4720
Dync1i1 5720 5691
Dctn1 6145 4917
Capza1 7204 4152
Dnaja1 7276 3992
Tuba4a 7159 3675
Tubb4a 7466 3029
Nr3c2 2385 6675
Actr10 2944 5266
Tubb4b 7571 2010

Click HERE to show all gene set members

All member genes
LPS OVA
Actr10 2944 5266
Actr1a 7338 4720
Ar 264 -5178
Capza1 7204 4152
Capza2 7653 8008
Capzb 5170 2822
Dctn1 6145 4917
Dctn2 3292 2492
Dctn3 326 -3090
Dctn4 7128 8231
Dctn5 5395 -1094
Dctn6 6420 6162
Dnaja1 7276 3992
Dnaja2 7931 5634
Dnaja4 7505 -1427
Dnajb1 1780 -1078
Dync1h1 1330 2837
Dync1i1 5720 5691
Dync1i2 -3869 -3708
Dync1li1 2606 -771
Dync1li2 -3512 711
Dynll1 3587 -3371
Dynll2 -1873 -1447
Fkbp4 5573 -1909
Fkbp5 5945 8602
Hsp90aa1 -2945 -7318
Hsp90ab1 -2327 -3989
Hspa1a -5052 -7003
Hspa1b 8108 5703
Hspa1l -2895 -4112
Hspa2 8226 7167
Hspa8 4969 1013
Nr3c1 -1001 2195
Nr3c2 2385 6675
Pgr -3509 -1617
Ptges3 3526 -5129
Stip1 6783 478
Tuba1a 7018 1821
Tuba1b 7821 4723
Tuba1c 4454 -1802
Tuba4a 7159 3675
Tuba8 -5535 -1623
Tubb2a 8077 4592
Tubb2b 7453 8823
Tubb3 5803 -2348
Tubb4a 7466 3029
Tubb4b 7571 2010
Tubb6 1793 -4650



POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION

POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
metric value
setSize 26
pMANOVA 0.00141
p.adjustMANOVA 0.0113
s.dist 0.473
s.LPS 0.238
s.OVA 0.409
p.LPS 0.0357
p.OVA 0.000308




Top 20 genes
Gene LPS OVA
Nup54 7762 8787
Ndc1 8208 8094
Rcc1 6041 7423
Tnpo1 4904 7000
Sec13 5615 5632
Nup37 5296 5638
Nup107 4389 6283
Ube2i 5452 4351
Pom121 4111 5761
Kpnb1 3075 5559
Ran 4885 2841
Sumo1 4747 2888
Rangap1 4496 2258
Nup205 626 6117
Nup85 792 4472
Ahctf1 404 4446
Nup35 391 1601

Click HERE to show all gene set members

All member genes
LPS OVA
Ahctf1 404 4446
Kpnb1 3075 5559
Ndc1 8208 8094
Nup107 4389 6283
Nup133 -3910 5676
Nup155 -5218 -2890
Nup160 -996 7310
Nup188 -459 3179
Nup205 626 6117
Nup35 391 1601
Nup37 5296 5638
Nup43 -1842 1241
Nup54 7762 8787
Nup62 -1432 -1887
Nup85 792 4472
Nup93 -6226 -1270
Nup98 -2864 2169
Pom121 4111 5761
Ran 4885 2841
Rangap1 4496 2258
Rcc1 6041 7423
Sec13 5615 5632
Seh1l -5053 4673
Sumo1 4747 2888
Tnpo1 4904 7000
Ube2i 5452 4351



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report