date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik 0.0259293
0610009E02Rik 0.7519591
0610009L18Rik -1.0644467
0610010K14Rik 0.4476085
0610012G03Rik -0.1633199
0610030E20Rik -0.6249661

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17595
duplicated_genes_present 0
num_profile_genes_in_sets 8418
num_profile_genes_not_in_sets 9177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 426
num_genesets_included 1178

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 9.33e-08 0.707 5.50e-06
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.65e-04 0.608 4.00e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 5.67e-04 0.575 7.04e-03
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 7.89e-04 0.560 9.11e-03
RHOBTB3 ATPASE CYCLE 10 2.45e-03 0.553 2.10e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 8.36e-04 0.535 9.38e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 9.28e-06 0.534 2.80e-04
CITRIC ACID CYCLE TCA CYCLE 22 2.49e-05 0.519 6.36e-04
NUCLEOBASE BIOSYNTHESIS 15 6.68e-04 0.507 8.03e-03
KERATAN SULFATE BIOSYNTHESIS 24 2.54e-05 0.497 6.36e-04
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.48e-08 0.493 1.16e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.52e-05 0.477 6.36e-04
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.46e-08 0.465 1.70e-06
KERATAN SULFATE KERATIN METABOLISM 30 1.46e-05 0.457 4.09e-04
CALNEXIN CALRETICULIN CYCLE 26 5.90e-05 0.455 1.20e-03
GLYCOGEN STORAGE DISEASES 12 6.44e-03 0.454 4.24e-02
GAP JUNCTION ASSEMBLY 21 3.14e-04 0.454 4.62e-03
ENDOSOMAL VACUOLAR PATHWAY 10 1.31e-02 -0.453 6.81e-02
RETROGRADE NEUROTROPHIN SIGNALLING 13 4.77e-03 0.452 3.39e-02
GLYCOGEN SYNTHESIS 14 3.63e-03 0.449 2.74e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 2.65e-04 0.439 4.00e-03
LDL CLEARANCE 16 2.46e-03 0.437 2.10e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 1.69e-02 0.436 8.00e-02
OLFACTORY SIGNALING PATHWAY 40 2.56e-06 -0.430 1.12e-04
RHO GTPASES ACTIVATE IQGAPS 23 3.81e-04 0.428 5.21e-03
RECEPTOR MEDIATED MITOPHAGY 11 1.49e-02 0.424 7.49e-02
PURINE SALVAGE 12 1.14e-02 0.422 6.22e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.74e-05 0.420 4.75e-04
CD28 DEPENDENT VAV1 PATHWAY 11 1.64e-02 0.418 7.89e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 1.65e-02 0.417 7.89e-02
N GLYCAN ANTENNAE ELONGATION 15 5.19e-03 0.417 3.56e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.24e-02 0.417 6.54e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 9.63e-03 0.415 5.44e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 2.35e-02 0.414 1.00e-01
GLYCOGEN METABOLISM 25 3.53e-04 0.413 5.01e-03
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 8.18e-03 0.408 4.92e-02
CYTOSOLIC TRNA AMINOACYLATION 24 5.42e-04 0.408 6.94e-03
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 9.58e-04 0.407 1.05e-02
GLYCOSPHINGOLIPID METABOLISM 38 1.44e-05 0.407 4.09e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 1.61e-03 0.398 1.57e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 2.11e-03 0.397 1.91e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 1.08e-02 0.394 5.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.83e-02 0.393 8.39e-02
CS DS DEGRADATION 14 1.24e-02 0.386 6.53e-02
IRE1ALPHA ACTIVATES CHAPERONES 50 2.69e-06 0.384 1.13e-04
KERATAN SULFATE DEGRADATION 11 2.84e-02 0.382 1.14e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 3.36e-03 0.379 2.62e-02
RECYCLING PATHWAY OF L1 40 3.41e-05 0.379 8.20e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 7.01e-03 0.378 4.49e-02
COPI MEDIATED ANTEROGRADE TRANSPORT 91 5.78e-10 0.376 5.23e-08


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 9.33e-08 7.07e-01 5.50e-06
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 2.65e-04 6.08e-01 4.00e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 5.67e-04 5.75e-01 7.04e-03
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 7.89e-04 5.60e-01 9.11e-03
RHOBTB3 ATPASE CYCLE 10 2.45e-03 5.53e-01 2.10e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 8.36e-04 5.35e-01 9.38e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 9.28e-06 5.34e-01 2.80e-04
CITRIC ACID CYCLE TCA CYCLE 22 2.49e-05 5.19e-01 6.36e-04
NUCLEOBASE BIOSYNTHESIS 15 6.68e-04 5.07e-01 8.03e-03
KERATAN SULFATE BIOSYNTHESIS 24 2.54e-05 4.97e-01 6.36e-04
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.48e-08 4.93e-01 1.16e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.52e-05 4.77e-01 6.36e-04
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.46e-08 4.65e-01 1.70e-06
KERATAN SULFATE KERATIN METABOLISM 30 1.46e-05 4.57e-01 4.09e-04
CALNEXIN CALRETICULIN CYCLE 26 5.90e-05 4.55e-01 1.20e-03
GLYCOGEN STORAGE DISEASES 12 6.44e-03 4.54e-01 4.24e-02
GAP JUNCTION ASSEMBLY 21 3.14e-04 4.54e-01 4.62e-03
ENDOSOMAL VACUOLAR PATHWAY 10 1.31e-02 -4.53e-01 6.81e-02
RETROGRADE NEUROTROPHIN SIGNALLING 13 4.77e-03 4.52e-01 3.39e-02
GLYCOGEN SYNTHESIS 14 3.63e-03 4.49e-01 2.74e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 2.65e-04 4.39e-01 4.00e-03
LDL CLEARANCE 16 2.46e-03 4.37e-01 2.10e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 1.69e-02 4.36e-01 8.00e-02
OLFACTORY SIGNALING PATHWAY 40 2.56e-06 -4.30e-01 1.12e-04
RHO GTPASES ACTIVATE IQGAPS 23 3.81e-04 4.28e-01 5.21e-03
RECEPTOR MEDIATED MITOPHAGY 11 1.49e-02 4.24e-01 7.49e-02
PURINE SALVAGE 12 1.14e-02 4.22e-01 6.22e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.74e-05 4.20e-01 4.75e-04
CD28 DEPENDENT VAV1 PATHWAY 11 1.64e-02 4.18e-01 7.89e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 1.65e-02 4.17e-01 7.89e-02
N GLYCAN ANTENNAE ELONGATION 15 5.19e-03 4.17e-01 3.56e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.24e-02 4.17e-01 6.54e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 9.63e-03 4.15e-01 5.44e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 2.35e-02 4.14e-01 1.00e-01
GLYCOGEN METABOLISM 25 3.53e-04 4.13e-01 5.01e-03
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 8.18e-03 4.08e-01 4.92e-02
CYTOSOLIC TRNA AMINOACYLATION 24 5.42e-04 4.08e-01 6.94e-03
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 9.58e-04 4.07e-01 1.05e-02
GLYCOSPHINGOLIPID METABOLISM 38 1.44e-05 4.07e-01 4.09e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 1.61e-03 3.98e-01 1.57e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 2.11e-03 3.97e-01 1.91e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 1.08e-02 3.94e-01 5.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.83e-02 3.93e-01 8.39e-02
CS DS DEGRADATION 14 1.24e-02 3.86e-01 6.53e-02
IRE1ALPHA ACTIVATES CHAPERONES 50 2.69e-06 3.84e-01 1.13e-04
KERATAN SULFATE DEGRADATION 11 2.84e-02 3.82e-01 1.14e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 3.36e-03 3.79e-01 2.62e-02
RECYCLING PATHWAY OF L1 40 3.41e-05 3.79e-01 8.20e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 7.01e-03 3.78e-01 4.49e-02
COPI MEDIATED ANTEROGRADE TRANSPORT 91 5.78e-10 3.76e-01 5.23e-08
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 3.33e-02 3.71e-01 1.30e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 3.31e-03 3.70e-01 2.60e-02
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 7.34e-06 3.70e-01 2.34e-04
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 4.51e-02 3.66e-01 1.60e-01
INTERFERON ALPHA BETA SIGNALING 53 4.94e-06 -3.63e-01 1.71e-04
BRANCHED CHAIN AMINO ACID CATABOLISM 21 4.42e-03 3.59e-01 3.19e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 2.43e-03 3.57e-01 2.10e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 5.15e-02 3.56e-01 1.75e-01
KILLING MECHANISMS 11 4.23e-02 -3.54e-01 1.53e-01
VLDLR INTERNALISATION AND DEGRADATION 12 3.50e-02 3.52e-01 1.33e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 4.84e-04 3.51e-01 6.34e-03
ER QUALITY CONTROL COMPARTMENT ERQC 21 5.66e-03 3.49e-01 3.83e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.99e-02 3.47e-01 8.86e-02
GOLGI TO ER RETROGRADE TRANSPORT 119 6.02e-11 3.47e-01 1.01e-08
INSULIN PROCESSING 24 3.26e-03 3.47e-01 2.59e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.26e-03 3.46e-01 1.31e-02
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 2.34e-04 3.45e-01 3.67e-03
FATTY ACYL COA BIOSYNTHESIS 32 7.84e-04 3.43e-01 9.11e-03
SULFUR AMINO ACID METABOLISM 23 4.78e-03 3.40e-01 3.39e-02
AGGREPHAGY 35 5.23e-04 3.39e-01 6.77e-03
GLUCONEOGENESIS 27 2.37e-03 3.38e-01 2.08e-02
HYALURONAN UPTAKE AND DEGRADATION 11 5.33e-02 3.36e-01 1.78e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 3.79e-06 3.34e-01 1.39e-04
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.90e-03 3.33e-01 1.77e-02
DERMATAN SULFATE BIOSYNTHESIS 11 5.65e-02 3.32e-01 1.87e-01
INTRAFLAGELLAR TRANSPORT 52 3.49e-05 3.32e-01 8.21e-04
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 4.93e-03 3.32e-01 3.43e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 5.11e-05 3.28e-01 1.08e-03
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 3.27e-03 3.27e-01 2.59e-02
INSULIN RECEPTOR RECYCLING 20 1.19e-02 3.25e-01 6.41e-02
HSF1 ACTIVATION 25 5.38e-03 3.22e-01 3.66e-02
SPRY REGULATION OF FGF SIGNALING 16 2.60e-02 3.22e-01 1.07e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 4.53e-02 3.21e-01 1.61e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 5.69e-13 3.20e-01 1.34e-10
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 5.54e-04 3.20e-01 7.02e-03
LYSOSOME VESICLE BIOGENESIS 33 1.53e-03 3.19e-01 1.52e-02
MATURATION OF NUCLEOPROTEIN 10 8.30e-02 -3.17e-01 2.42e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 2.42e-02 3.16e-01 1.02e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 3.47e-02 -3.15e-01 1.32e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 1.22e-10 3.13e-01 1.44e-08
PEROXISOMAL LIPID METABOLISM 27 4.92e-03 3.13e-01 3.43e-02
PROTEIN METHYLATION 17 2.56e-02 3.13e-01 1.06e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 5.85e-07 3.12e-01 3.00e-05
MHC CLASS II ANTIGEN PRESENTATION 102 5.62e-08 3.11e-01 3.48e-06
RAF ACTIVATION 34 1.69e-03 3.11e-01 1.63e-02
CTLA4 INHIBITORY SIGNALING 20 1.65e-02 3.10e-01 7.89e-02
RAP1 SIGNALLING 15 3.79e-02 3.10e-01 1.41e-01
TRNA AMINOACYLATION 42 5.63e-04 3.08e-01 7.04e-03
HSF1 DEPENDENT TRANSACTIVATION 33 2.39e-03 3.06e-01 2.08e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 9.44e-02 -3.05e-01 2.67e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 3.46e-02 -3.05e-01 1.32e-01
ASPARTATE AND ASPARAGINE METABOLISM 10 9.79e-02 3.02e-01 2.72e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 4.24e-03 3.02e-01 3.08e-02
SPHINGOLIPID METABOLISM 80 3.33e-06 3.01e-01 1.27e-04
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 6.12e-02 3.00e-01 1.96e-01
SELECTIVE AUTOPHAGY 72 1.10e-05 3.00e-01 3.24e-04
EPHRIN SIGNALING 19 2.41e-02 2.99e-01 1.02e-01
DARPP 32 EVENTS 23 1.32e-02 2.99e-01 6.82e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 8.66e-02 -2.98e-01 2.49e-01
CARGO CONCENTRATION IN THE ER 31 4.21e-03 2.97e-01 3.08e-02
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 6.65e-02 2.94e-01 2.08e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 9.15e-02 2.94e-01 2.60e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 8.69e-03 2.92e-01 5.11e-02
ASPARAGINE N LINKED GLYCOSYLATION 285 2.66e-17 2.91e-01 1.57e-14
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 6.91e-02 2.91e-01 2.14e-01
PEROXISOMAL PROTEIN IMPORT 59 1.12e-04 2.91e-01 2.07e-03
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 1.21e-02 -2.90e-01 6.47e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 2.52e-02 2.89e-01 1.05e-01
HDMS DEMETHYLATE HISTONES 30 6.22e-03 -2.89e-01 4.17e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 2.75e-03 2.88e-01 2.28e-02
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 29 7.83e-03 -2.85e-01 4.81e-02
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 14 6.46e-02 2.85e-01 2.02e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 3.14e-02 2.85e-01 1.24e-01
IRON UPTAKE AND TRANSPORT 51 4.52e-04 2.84e-01 5.99e-03
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 5.73e-02 2.84e-01 1.88e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 1.71e-04 2.83e-01 2.93e-03
AUTOPHAGY 139 9.74e-09 2.82e-01 8.20e-07
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 3.56e-03 2.81e-01 2.73e-02
ACYL CHAIN REMODELLING OF PE 17 4.78e-02 2.77e-01 1.66e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 16 5.49e-02 2.77e-01 1.83e-01
INTERFERON GAMMA SIGNALING 74 3.78e-05 -2.77e-01 8.73e-04
RAB GERANYLGERANYLATION 57 3.61e-04 2.73e-01 5.07e-03
PKMTS METHYLATE HISTONE LYSINES 51 7.53e-04 -2.73e-01 8.87e-03
LYSINE CATABOLISM 11 1.18e-01 2.72e-01 3.08e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 8.98e-02 2.72e-01 2.57e-01
RESOLUTION OF D LOOP STRUCTURES 31 9.15e-03 -2.71e-01 5.23e-02
CHOLESTEROL BIOSYNTHESIS 24 2.20e-02 2.70e-01 9.61e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 54 5.98e-04 -2.70e-01 7.26e-03
GAP JUNCTION DEGRADATION 11 1.21e-01 2.70e-01 3.12e-01
COPII MEDIATED VESICLE TRANSPORT 66 1.70e-04 2.68e-01 2.93e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 1.73e-04 2.67e-01 2.93e-03
SIGNAL AMPLIFICATION 31 1.00e-02 2.67e-01 5.58e-02
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 6.42e-02 2.67e-01 2.02e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 9.58e-02 2.67e-01 2.70e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 9.61e-02 2.67e-01 2.70e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 4.87e-10 2.65e-01 4.78e-08
BUDDING AND MATURATION OF HIV VIRION 27 1.71e-02 2.65e-01 8.01e-02
SIGNALING BY HEDGEHOG 141 5.58e-08 2.65e-01 3.48e-06
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 9.80e-02 2.65e-01 2.72e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 28 1.53e-02 2.65e-01 7.60e-02
G ALPHA Z SIGNALLING EVENTS 45 2.20e-03 2.64e-01 1.98e-02
G1 S SPECIFIC TRANSCRIPTION 26 2.08e-02 2.62e-01 9.25e-02
NUCLEOTIDE SALVAGE 21 3.78e-02 2.62e-01 1.40e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 7.92e-02 2.62e-01 2.34e-01
FORMATION OF APOPTOSOME 10 1.52e-01 2.62e-01 3.69e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 3.32e-04 2.61e-01 4.77e-03
PENTOSE PHOSPHATE PATHWAY 13 1.03e-01 2.61e-01 2.84e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 1.53e-01 2.61e-01 3.70e-01
SEROTONIN RECEPTORS 10 1.55e-01 2.60e-01 3.71e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 7.18e-02 2.60e-01 2.19e-01
LAMININ INTERACTIONS 29 1.56e-02 -2.59e-01 7.69e-02
HEDGEHOG OFF STATE 106 3.98e-06 2.59e-01 1.42e-04
ERKS ARE INACTIVATED 13 1.06e-01 2.59e-01 2.86e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 1.81e-02 2.58e-01 8.35e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 4.62e-02 2.57e-01 1.63e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 5.97e-02 2.56e-01 1.93e-01
ACTIVATION OF RAC1 13 1.10e-01 2.56e-01 2.93e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 2.39e-02 2.56e-01 1.01e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 1.25e-01 -2.56e-01 3.20e-01
GLYCOSAMINOGLYCAN METABOLISM 113 2.78e-06 2.55e-01 1.13e-04
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 1.45e-01 2.54e-01 3.59e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 1.64e-02 2.53e-01 7.89e-02
PROCESSING AND ACTIVATION OF SUMO 10 1.66e-01 2.53e-01 3.88e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 8.71e-03 2.53e-01 5.11e-02
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 1.15e-01 -2.53e-01 3.01e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 6.42e-02 2.52e-01 2.02e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.13e-02 2.52e-01 2.60e-01
MITOPHAGY 29 1.94e-02 2.51e-01 8.74e-02
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 1.70e-01 -2.51e-01 3.93e-01
PROTEIN FOLDING 90 4.10e-05 2.50e-01 9.11e-04
O LINKED GLYCOSYLATION OF MUCINS 40 6.63e-03 2.48e-01 4.30e-02
TELOMERE C STRAND SYNTHESIS INITIATION 13 1.24e-01 2.46e-01 3.18e-01
METABOLISM OF POLYAMINES 57 1.34e-03 2.46e-01 1.39e-02
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.51e-02 2.45e-01 1.05e-01
RHOBTB2 GTPASE CYCLE 23 4.24e-02 2.45e-01 1.53e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 92 5.23e-05 2.44e-01 1.08e-03
INTERACTION BETWEEN L1 AND ANKYRINS 27 2.84e-02 -2.44e-01 1.14e-01
HEDGEHOG LIGAND BIOGENESIS 61 1.02e-03 2.43e-01 1.12e-02
PROLACTIN RECEPTOR SIGNALING 11 1.63e-01 2.43e-01 3.83e-01
ATTENUATION PHASE 23 4.41e-02 2.43e-01 1.58e-01
PROTEIN LOCALIZATION 158 1.54e-07 2.42e-01 8.66e-06
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 1.87e-01 2.41e-01 4.19e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 1.50e-01 2.40e-01 3.67e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 1.51e-01 2.40e-01 3.69e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 1.69e-01 -2.39e-01 3.93e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 5.79e-02 2.39e-01 1.90e-01
METABOLISM OF CARBOHYDRATES 260 3.79e-11 2.38e-01 7.43e-09
GABA RECEPTOR ACTIVATION 55 2.25e-03 2.38e-01 1.99e-02
PLATELET ADHESION TO EXPOSED COLLAGEN 13 1.37e-01 -2.38e-01 3.43e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.57e-02 2.38e-01 1.34e-01
SIGNALING BY NODAL 15 1.11e-01 -2.38e-01 2.93e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 1.54e-02 -2.37e-01 7.60e-02
G0 AND EARLY G1 25 4.06e-02 2.37e-01 1.48e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 6.88e-02 2.35e-01 2.13e-01
TRIGLYCERIDE CATABOLISM 14 1.29e-01 2.34e-01 3.28e-01
REGULATION OF IFNG SIGNALING 13 1.44e-01 2.34e-01 3.58e-01
ABC TRANSPORTER DISORDERS 70 7.36e-04 2.33e-01 8.76e-03
CHEMOKINE RECEPTORS BIND CHEMOKINES 17 9.62e-02 -2.33e-01 2.70e-01
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 1.81e-01 -2.33e-01 4.09e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 1.43e-03 2.32e-01 1.44e-02
UNFOLDED PROTEIN RESPONSE UPR 85 2.14e-04 2.32e-01 3.46e-03
PLASMA LIPOPROTEIN CLEARANCE 28 3.40e-02 2.32e-01 1.31e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 1.11e-01 -2.30e-01 2.93e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 3.56e-02 2.29e-01 1.34e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.88e-01 2.29e-01 4.19e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 12 1.70e-01 2.29e-01 3.93e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 3.04e-04 2.28e-01 4.54e-03
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 6.48e-03 2.27e-01 4.24e-02
EXTRA NUCLEAR ESTROGEN SIGNALING 68 1.20e-03 2.27e-01 1.28e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.73e-01 2.27e-01 3.97e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 73 8.08e-04 2.27e-01 9.16e-03
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 3.22e-02 2.26e-01 1.27e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 2.27e-02 2.26e-01 9.78e-02
INTEGRATION OF ENERGY METABOLISM 100 9.94e-05 2.25e-01 1.89e-03
METABOLISM OF NUCLEOTIDES 92 1.97e-04 2.25e-01 3.23e-03
PLATELET SENSITIZATION BY LDL 15 1.34e-01 2.23e-01 3.37e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 5.84e-02 2.23e-01 1.90e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 4.94e-02 2.23e-01 1.70e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.13e-01 -2.22e-01 2.97e-01
SYNTHESIS OF PA 29 3.93e-02 2.21e-01 1.44e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 9.64e-03 2.21e-01 5.44e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.05e-01 2.20e-01 2.85e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 1.07e-01 2.20e-01 2.87e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 6.27e-03 2.19e-01 4.18e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.72e-01 -2.19e-01 3.96e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 2.33e-02 2.18e-01 1.00e-01
SCAVENGING OF HEME FROM PLASMA 12 1.91e-01 -2.18e-01 4.24e-01
SIGNAL TRANSDUCTION BY L1 21 8.47e-02 2.17e-01 2.46e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 1.61e-02 -2.17e-01 7.85e-02
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.45e-01 -2.17e-01 3.59e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 1.48e-01 2.16e-01 3.64e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 1.23e-01 2.16e-01 3.17e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.04e-01 2.15e-01 2.85e-01
PYRUVATE METABOLISM 27 5.33e-02 2.15e-01 1.78e-01
INTERLEUKIN 10 SIGNALING 19 1.05e-01 -2.15e-01 2.85e-01
SARS COV 2 INFECTION 65 2.78e-03 2.15e-01 2.29e-02
PROTEIN UBIQUITINATION 70 1.93e-03 2.14e-01 1.78e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 8.95e-02 2.14e-01 2.57e-01
SIALIC ACID METABOLISM 32 3.64e-02 2.14e-01 1.36e-01
PI 3K CASCADE FGFR2 17 1.27e-01 -2.14e-01 3.24e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 2.43e-01 -2.13e-01 4.84e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 24 7.15e-02 2.13e-01 2.19e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 2.88e-03 2.12e-01 2.36e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 6.20e-02 2.11e-01 1.98e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 2.26e-02 2.11e-01 9.78e-02
HS GAG BIOSYNTHESIS 30 4.57e-02 2.11e-01 1.62e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 64 3.75e-03 -2.10e-01 2.82e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.60e-01 2.09e-01 3.79e-01
MTORC1 MEDIATED SIGNALLING 24 7.66e-02 2.09e-01 2.30e-01
HDACS DEACETYLATE HISTONES 50 1.09e-02 -2.08e-01 6.03e-02
CGMP EFFECTS 15 1.65e-01 -2.07e-01 3.85e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 1.61e-03 2.07e-01 1.57e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 1.66e-01 -2.07e-01 3.88e-01
ACYL CHAIN REMODELLING OF PG 10 2.59e-01 2.06e-01 5.02e-01
FERTILIZATION 13 1.98e-01 -2.06e-01 4.32e-01
INTEGRIN CELL SURFACE INTERACTIONS 75 2.02e-03 -2.06e-01 1.85e-02
G BETA GAMMA SIGNALLING THROUGH CDC42 19 1.20e-01 2.06e-01 3.10e-01
FCERI MEDIATED NF KB ACTIVATION 76 1.90e-03 2.06e-01 1.77e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 1.67e-01 2.06e-01 3.90e-01
INTRA GOLGI TRAFFIC 43 1.96e-02 2.06e-01 8.81e-02
TRANS GOLGI NETWORK VESICLE BUDDING 70 2.94e-03 2.06e-01 2.39e-02
PROCESSING OF SMDT1 16 1.55e-01 2.06e-01 3.71e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 1.55e-01 2.05e-01 3.71e-01
SYNTHESIS OF PC 26 7.09e-02 2.05e-01 2.19e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 2.30e-04 2.04e-01 3.66e-03
AMINE LIGAND BINDING RECEPTORS 29 5.70e-02 2.04e-01 1.88e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 2.24e-02 2.04e-01 9.75e-02
GABA B RECEPTOR ACTIVATION 40 2.62e-02 2.03e-01 1.07e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.69e-02 -2.03e-01 1.64e-01
REGULATION OF INSULIN SECRETION 72 2.98e-03 2.02e-01 2.41e-02
MTOR SIGNALLING 40 2.69e-02 2.02e-01 1.09e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 3.35e-02 2.02e-01 1.30e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 1.63e-01 -2.01e-01 3.83e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 4.89e-02 2.01e-01 1.69e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 1.61e-02 2.01e-01 7.85e-02
KINESINS 47 1.77e-02 2.00e-01 8.20e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 84 1.55e-03 2.00e-01 1.53e-02
PROLONGED ERK ACTIVATION EVENTS 13 2.13e-01 1.99e-01 4.51e-01
NCAM1 INTERACTIONS 42 2.55e-02 -1.99e-01 1.06e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 1.44e-01 1.99e-01 3.58e-01
ERYTHROPOIETIN ACTIVATES RAS 13 2.14e-01 1.99e-01 4.51e-01
MEMBRANE TRAFFICKING 582 2.93e-16 1.99e-01 1.15e-13
PEPTIDE HORMONE METABOLISM 60 7.82e-03 1.99e-01 4.81e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 1.98e-01 1.99e-01 4.32e-01
CELLULAR RESPONSE TO HEAT STRESS 94 9.54e-04 1.97e-01 1.05e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 51 1.51e-02 -1.97e-01 7.57e-02
ACTIVATION OF BH3 ONLY PROTEINS 30 6.25e-02 1.97e-01 1.99e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 1.04e-02 1.96e-01 5.75e-02
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 3.92e-02 -1.96e-01 1.44e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 1.04e-01 1.96e-01 2.85e-01
DISEASES OF DNA REPAIR 11 2.62e-01 1.95e-01 5.03e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.31e-02 1.95e-01 6.81e-02
REGULATION OF KIT SIGNALING 16 1.77e-01 1.95e-01 4.04e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 1.01e-04 1.95e-01 1.89e-03
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 1.32e-01 -1.94e-01 3.34e-01
STABILIZATION OF P53 54 1.36e-02 1.94e-01 6.93e-02
CA DEPENDENT EVENTS 36 4.38e-02 1.94e-01 1.57e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.33e-01 1.94e-01 3.35e-01
CD28 CO STIMULATION 31 6.21e-02 1.94e-01 1.98e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 182 6.78e-06 1.94e-01 2.22e-04
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 1.72e-03 1.93e-01 1.65e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.71e-02 1.93e-01 2.30e-01
MITOTIC METAPHASE AND ANAPHASE 207 1.79e-06 1.93e-01 8.44e-05
FATTY ACID METABOLISM 146 6.12e-05 1.92e-01 1.21e-03
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 51 1.76e-02 -1.92e-01 8.20e-02
NEUTROPHIL DEGRANULATION 386 1.15e-10 1.91e-01 1.44e-08
REGULATION OF RAS BY GAPS 66 7.18e-03 1.91e-01 4.57e-02
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 4.23e-03 1.91e-01 3.08e-02
PINK1 PRKN MEDIATED MITOPHAGY 22 1.21e-01 1.91e-01 3.12e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 3.11e-03 1.90e-01 2.49e-02
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.52e-01 1.90e-01 3.69e-01
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 10 2.99e-01 -1.90e-01 5.46e-01
NEDDYLATION 219 1.33e-06 1.90e-01 6.54e-05
METHYLATION 11 2.77e-01 1.89e-01 5.19e-01
VXPX CARGO TARGETING TO CILIUM 19 1.53e-01 1.89e-01 3.70e-01
HEME SIGNALING 46 2.64e-02 -1.89e-01 1.07e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 3.03e-01 1.88e-01 5.50e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 3.19e-04 1.88e-01 4.65e-03
DSCAM INTERACTIONS 11 2.83e-01 -1.87e-01 5.24e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 8.12e-02 1.87e-01 2.39e-01
SYNTHESIS OF PE 13 2.44e-01 1.87e-01 4.84e-01
TBC RABGAPS 43 3.43e-02 1.87e-01 1.31e-01
AMINO ACIDS REGULATE MTORC1 51 2.15e-02 1.86e-01 9.47e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 1.32e-01 1.86e-01 3.32e-01
VESICLE MEDIATED TRANSPORT 615 4.82e-15 1.85e-01 1.42e-12
NUCLEOBASE CATABOLISM 31 7.40e-02 1.85e-01 2.23e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 1.39e-02 1.85e-01 7.05e-02
NEGATIVE REGULATION OF MET ACTIVITY 20 1.52e-01 1.85e-01 3.70e-01
RHOF GTPASE CYCLE 41 4.11e-02 1.84e-01 1.49e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 23 1.27e-01 1.84e-01 3.24e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 1.37e-03 1.83e-01 1.40e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 2.09e-02 1.83e-01 9.27e-02
FCGR3A MEDIATED IL10 SYNTHESIS 32 7.32e-02 1.83e-01 2.22e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 2.74e-01 -1.83e-01 5.15e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 8.32e-03 1.82e-01 4.98e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 18 1.81e-01 1.82e-01 4.09e-01
METAL ION SLC TRANSPORTERS 25 1.16e-01 1.82e-01 3.03e-01
INTERFERON SIGNALING 162 6.96e-05 -1.81e-01 1.34e-03
DEFECTS IN COBALAMIN B12 METABOLISM 13 2.59e-01 1.81e-01 5.02e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 2.42e-01 1.81e-01 4.82e-01
RORA ACTIVATES GENE EXPRESSION 18 1.85e-01 -1.81e-01 4.15e-01
HEDGEHOG ON STATE 82 4.83e-03 1.80e-01 3.40e-02
METABOLISM OF FAT SOLUBLE VITAMINS 32 7.81e-02 1.80e-01 2.32e-01
CRMPS IN SEMA3A SIGNALING 16 2.14e-01 -1.80e-01 4.51e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 2.00e-01 1.79e-01 4.36e-01
CILIUM ASSEMBLY 192 1.94e-05 1.79e-01 5.19e-04
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 3.04e-01 1.79e-01 5.50e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 7.12e-02 1.79e-01 2.19e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 1.40e-03 1.79e-01 1.42e-02
REDUCTION OF CYTOSOLIC CA LEVELS 12 2.87e-01 -1.77e-01 5.28e-01
GPCR LIGAND BINDING 271 5.44e-07 1.77e-01 2.91e-05
ASSEMBLY OF THE HIV VIRION 16 2.21e-01 1.77e-01 4.57e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 1.72e-01 1.76e-01 3.96e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.21e-01 -1.76e-01 3.12e-01
EPHB MEDIATED FORWARD SIGNALING 42 4.93e-02 1.75e-01 1.70e-01
COMPLEX I BIOGENESIS 56 2.34e-02 -1.75e-01 1.00e-01
COLLAGEN CHAIN TRIMERIZATION 41 5.26e-02 -1.75e-01 1.77e-01
FCERI MEDIATED MAPK ACTIVATION 28 1.10e-01 1.74e-01 2.93e-01
G ALPHA Q SIGNALLING EVENTS 155 1.82e-04 1.74e-01 3.02e-03
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 1.77e-01 1.74e-01 4.04e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 3.56e-03 1.74e-01 2.73e-02
EGFR DOWNREGULATION 28 1.11e-01 1.74e-01 2.94e-01
PI 3K CASCADE FGFR1 16 2.29e-01 -1.74e-01 4.69e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 243 3.18e-06 1.74e-01 1.25e-04
STRIATED MUSCLE CONTRACTION 27 1.19e-01 -1.74e-01 3.08e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 3.56e-03 1.73e-01 2.73e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 1.84e-02 1.73e-01 8.41e-02
SARS COV 1 INFECTION 48 3.84e-02 1.73e-01 1.42e-01
PCP CE PATHWAY 89 4.99e-03 1.72e-01 3.46e-02
SIGNALING BY FGFR3 34 8.24e-02 1.72e-01 2.41e-01
ACYL CHAIN REMODELLING OF PC 17 2.21e-01 1.72e-01 4.57e-01
SEPARATION OF SISTER CHROMATIDS 166 1.41e-04 1.71e-01 2.56e-03
PHOSPHOLIPID METABOLISM 188 5.25e-05 1.71e-01 1.08e-03
MITOTIC G1 PHASE AND G1 S TRANSITION 142 4.36e-04 1.71e-01 5.91e-03
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 3.13e-02 1.71e-01 1.24e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 9.98e-03 1.71e-01 5.58e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.58e-01 -1.70e-01 3.75e-01
G1 S DNA DAMAGE CHECKPOINTS 65 1.78e-02 1.70e-01 8.21e-02
GLUCOSE METABOLISM 81 8.68e-03 1.69e-01 5.11e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 1.30e-01 1.68e-01 3.29e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 9.98e-02 -1.68e-01 2.77e-01
TRANSCRIPTIONAL REGULATION BY MECP2 59 2.63e-02 -1.67e-01 1.07e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 68 1.74e-02 1.67e-01 8.14e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 1.57e-01 1.67e-01 3.74e-01
ANCHORING FIBRIL FORMATION 14 2.81e-01 -1.67e-01 5.22e-01
TIGHT JUNCTION INTERACTIONS 16 2.51e-01 1.66e-01 4.94e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 6.36e-02 1.65e-01 2.01e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 15 2.68e-01 1.65e-01 5.08e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 2.13e-01 -1.65e-01 4.51e-01
SIGNALING BY FGFR4 34 9.67e-02 1.65e-01 2.70e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 2.70e-01 1.65e-01 5.11e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1230 4.88e-22 1.65e-01 5.75e-19
PRC2 METHYLATES HISTONES AND DNA 33 1.02e-01 -1.65e-01 2.81e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.14e-01 1.64e-01 2.98e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 3.06e-01 -1.64e-01 5.51e-01
INTERLEUKIN 12 FAMILY SIGNALING 43 6.30e-02 1.64e-01 2.00e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 3.56e-02 1.64e-01 1.34e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 1.84e-01 1.64e-01 4.14e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 224 2.59e-05 1.63e-01 6.36e-04
INTERLEUKIN 12 SIGNALING 37 8.60e-02 1.63e-01 2.48e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 3.73e-01 1.63e-01 6.07e-01
OPIOID SIGNALLING 87 8.99e-03 1.62e-01 5.21e-02
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 25 1.61e-01 -1.62e-01 3.80e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 3.78e-01 1.61e-01 6.07e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 3.55e-01 1.61e-01 5.98e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 187 1.58e-04 1.60e-01 2.82e-03
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 1.23e-02 1.60e-01 6.52e-02
ORC1 REMOVAL FROM CHROMATIN 67 2.36e-02 1.60e-01 1.00e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 3.60e-01 1.60e-01 6.01e-01
PRE NOTCH PROCESSING IN GOLGI 18 2.42e-01 1.59e-01 4.82e-01
MET ACTIVATES RAP1 AND RAC1 10 3.83e-01 1.59e-01 6.09e-01
RHO GTPASES ACTIVATE FORMINS 119 2.72e-03 1.59e-01 2.27e-02
FRS MEDIATED FGFR3 SIGNALING 15 2.86e-01 1.59e-01 5.26e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 2.30e-01 -1.59e-01 4.71e-01
MITOCHONDRIAL PROTEIN IMPORT 63 2.94e-02 1.59e-01 1.17e-01
MUCOPOLYSACCHARIDOSES 11 3.63e-01 1.58e-01 6.02e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.32e-01 1.58e-01 4.72e-01
HOST INTERACTIONS OF HIV FACTORS 125 2.25e-03 1.58e-01 1.99e-02
EPH EPHRIN SIGNALING 92 8.94e-03 1.58e-01 5.21e-02
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 3.08e-01 1.57e-01 5.52e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 5.21e-02 1.57e-01 1.76e-01
SIGNALING BY HIPPO 20 2.24e-01 1.57e-01 4.61e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 1.20e-02 1.57e-01 6.43e-02
ENOS ACTIVATION 11 3.68e-01 1.57e-01 6.06e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 7.25e-02 1.57e-01 2.21e-01
DNA METHYLATION 24 1.85e-01 -1.56e-01 4.15e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 9.16e-02 -1.56e-01 2.60e-01
PARASITE INFECTION 54 4.74e-02 1.56e-01 1.66e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 6.35e-03 1.56e-01 4.20e-02
CHAPERONE MEDIATED AUTOPHAGY 21 2.17e-01 1.56e-01 4.53e-01
DNA REPLICATION PRE INITIATION 80 1.67e-02 1.55e-01 7.91e-02
DEGRADATION OF AXIN 53 5.13e-02 1.55e-01 1.75e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 1.61e-02 1.55e-01 7.85e-02
SHC1 EVENTS IN EGFR SIGNALING 11 3.74e-01 1.55e-01 6.07e-01
DEGRADATION OF DVL 55 4.82e-02 1.54e-01 1.67e-01
PHASE 2 PLATEAU PHASE 10 3.99e-01 -1.54e-01 6.24e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 2.59e-01 1.54e-01 5.02e-01
TCR SIGNALING 101 7.61e-03 1.54e-01 4.78e-02
COHESIN LOADING ONTO CHROMATIN 10 4.00e-01 -1.54e-01 6.24e-01
INOSITOL PHOSPHATE METABOLISM 46 7.16e-02 1.54e-01 2.19e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 2.13e-01 1.54e-01 4.51e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 3.04e-01 1.53e-01 5.50e-01
EUKARYOTIC TRANSLATION ELONGATION 88 1.30e-02 -1.53e-01 6.80e-02
RAB REGULATION OF TRAFFICKING 119 3.91e-03 1.53e-01 2.92e-02
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 3.59e-01 -1.53e-01 6.01e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 2.37e-01 1.53e-01 4.78e-01
METABOLISM OF LIPIDS 619 1.05e-10 1.53e-01 1.44e-08
THE NLRP3 INFLAMMASOME 15 3.08e-01 -1.52e-01 5.52e-01
G ALPHA I SIGNALLING EVENTS 207 1.74e-04 1.52e-01 2.93e-03
G PROTEIN MEDIATED EVENTS 52 5.97e-02 1.51e-01 1.93e-01
C TYPE LECTIN RECEPTORS CLRS 112 5.80e-03 1.51e-01 3.90e-02
TRAF6 MEDIATED IRF7 ACTIVATION 15 3.14e-01 -1.50e-01 5.57e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 2.33e-01 1.50e-01 4.73e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 2.84e-01 1.50e-01 5.25e-01
MET ACTIVATES PTK2 SIGNALING 29 1.62e-01 -1.50e-01 3.83e-01
GP1B IX V ACTIVATION SIGNALLING 11 3.90e-01 -1.50e-01 6.16e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 25 1.97e-01 1.49e-01 4.30e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 8.49e-02 1.48e-01 2.46e-01
HYALURONAN METABOLISM 15 3.20e-01 1.48e-01 5.64e-01
INTERLEUKIN 15 SIGNALING 12 3.74e-01 -1.48e-01 6.07e-01
CLEC7A DECTIN 1 SIGNALING 94 1.33e-02 1.48e-01 6.83e-02
DEADENYLATION OF MRNA 25 2.02e-01 1.48e-01 4.36e-01
L1CAM INTERACTIONS 108 8.17e-03 1.47e-01 4.92e-02
AQUAPORIN MEDIATED TRANSPORT 41 1.04e-01 1.47e-01 2.84e-01
CELLULAR RESPONSE TO HYPOXIA 72 3.17e-02 1.46e-01 1.25e-01
DAG AND IP3 SIGNALING 40 1.13e-01 1.45e-01 2.97e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 2.19e-01 1.45e-01 4.57e-01
FGFR1 LIGAND BINDING AND ACTIVATION 10 4.28e-01 -1.45e-01 6.46e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 3.87e-01 1.44e-01 6.13e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 4.32e-01 1.44e-01 6.49e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 4.32e-01 1.44e-01 6.49e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 20 2.67e-01 1.43e-01 5.08e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 7.42e-02 1.43e-01 2.23e-01
SIGNALLING TO ERKS 33 1.55e-01 1.43e-01 3.71e-01
TNF SIGNALING 43 1.05e-01 1.43e-01 2.85e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 66 4.47e-02 -1.43e-01 1.60e-01
INTERLEUKIN 6 SIGNALING 10 4.34e-01 1.43e-01 6.50e-01
METABOLISM OF STEROIDS 117 7.75e-03 1.43e-01 4.81e-02
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 3.74e-01 1.42e-01 6.07e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 2.38e-01 1.42e-01 4.78e-01
FRS MEDIATED FGFR4 SIGNALING 15 3.41e-01 1.42e-01 5.84e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 2.85e-01 1.42e-01 5.25e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 6.00e-02 1.42e-01 1.93e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 5.12e-02 1.41e-01 1.75e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 2.14e-01 1.41e-01 4.51e-01
POLO LIKE KINASE MEDIATED EVENTS 14 3.66e-01 1.40e-01 6.05e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 95 1.89e-02 1.39e-01 8.61e-02
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 3.20e-01 1.39e-01 5.64e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 3.36e-01 -1.39e-01 5.79e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 9.07e-03 1.39e-01 5.21e-02
GLUTATHIONE CONJUGATION 30 1.89e-01 1.39e-01 4.20e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 4.26e-01 -1.39e-01 6.46e-01
DISEASES OF GLYCOSYLATION 123 8.06e-03 1.38e-01 4.89e-02
EPIGENETIC REGULATION OF GENE EXPRESSION 107 1.35e-02 -1.38e-01 6.92e-02
PURINE CATABOLISM 16 3.39e-01 1.38e-01 5.84e-01
PHASE II CONJUGATION OF COMPOUNDS 64 5.64e-02 1.38e-01 1.87e-01
PEPTIDE LIGAND BINDING RECEPTORS 112 1.19e-02 1.38e-01 6.42e-02
UNWINDING OF DNA 12 4.09e-01 1.38e-01 6.28e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 69 4.85e-02 -1.37e-01 1.68e-01
SARS COV INFECTIONS 140 5.05e-03 1.37e-01 3.48e-02
SEMA3A PAK DEPENDENT AXON REPULSION 16 3.42e-01 1.37e-01 5.85e-01
NEURONAL SYSTEM 370 6.14e-06 1.37e-01 2.07e-04
INTERLEUKIN 20 FAMILY SIGNALING 14 3.76e-01 -1.37e-01 6.07e-01
SIGNALING BY NTRKS 129 7.43e-03 1.37e-01 4.71e-02
ZINC TRANSPORTERS 16 3.46e-01 1.36e-01 5.88e-01
RMTS METHYLATE HISTONE ARGININES 47 1.08e-01 -1.36e-01 2.88e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 4.69e-03 1.36e-01 3.37e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 3.63e-01 1.36e-01 6.02e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 1.01e-01 1.36e-01 2.78e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 96 2.22e-02 -1.35e-01 9.67e-02
INNATE IMMUNE SYSTEM 779 1.71e-10 1.35e-01 1.83e-08
SIGNALING BY RETINOIC ACID 33 1.80e-01 1.35e-01 4.09e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 316 3.92e-05 1.35e-01 8.88e-04
BIOLOGICAL OXIDATIONS 126 9.06e-03 1.35e-01 5.21e-02
SHC MEDIATED CASCADE FGFR3 13 4.01e-01 1.35e-01 6.24e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 4.02e-01 1.34e-01 6.24e-01
NONSENSE MEDIATED DECAY NMD 110 1.52e-02 -1.34e-01 7.60e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 3.70e-01 1.34e-01 6.07e-01
RAS PROCESSING 24 2.58e-01 1.33e-01 5.02e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 4.05e-01 1.33e-01 6.24e-01
DNA REPLICATION 122 1.10e-02 1.33e-01 6.05e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 2.31e-01 1.33e-01 4.71e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 4.66e-01 1.33e-01 6.77e-01
INTERLEUKIN 1 SIGNALING 96 2.43e-02 1.33e-01 1.02e-01
ADAPTIVE IMMUNE SYSTEM 611 2.37e-08 1.33e-01 1.70e-06
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.17e-01 1.33e-01 5.62e-01
SIGNALING BY EGFR 47 1.16e-01 1.32e-01 3.03e-01
GPVI MEDIATED ACTIVATION CASCADE 31 2.02e-01 1.32e-01 4.36e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 7.34e-02 1.32e-01 2.22e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 8.88e-02 1.31e-01 2.55e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 8.08e-02 1.31e-01 2.39e-01
CD209 DC SIGN SIGNALING 18 3.35e-01 1.31e-01 5.78e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 4.14e-01 -1.31e-01 6.32e-01
OTHER SEMAPHORIN INTERACTIONS 19 3.26e-01 -1.30e-01 5.69e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 3.82e-01 1.30e-01 6.09e-01
HOMOLOGY DIRECTED REPAIR 111 1.93e-02 -1.29e-01 8.72e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.61e-01 1.28e-01 6.74e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 2.17e-01 1.28e-01 4.53e-01
ESTROGEN DEPENDENT GENE EXPRESSION 108 2.15e-02 -1.28e-01 9.47e-02
DAP12 INTERACTIONS 30 2.25e-01 -1.28e-01 4.63e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 3.91e-01 -1.28e-01 6.16e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 1.72e-01 -1.28e-01 3.96e-01
HIV INFECTION 221 1.07e-03 1.28e-01 1.14e-02
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 4.44e-01 1.28e-01 6.57e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 28 2.45e-01 -1.27e-01 4.85e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 2.63e-01 1.27e-01 5.03e-01
SIGNALING BY VEGF 103 2.63e-02 1.27e-01 1.07e-01
S PHASE 154 6.68e-03 1.27e-01 4.30e-02
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 2.38e-01 1.27e-01 4.78e-01
NUCLEAR SIGNALING BY ERBB4 31 2.23e-01 1.27e-01 4.60e-01
PI METABOLISM 80 5.04e-02 1.27e-01 1.73e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 2.56e-01 1.26e-01 5.01e-01
REGULATION OF TNFR1 SIGNALING 34 2.03e-01 1.26e-01 4.36e-01
REGULATION OF BACH1 ACTIVITY 11 4.69e-01 1.26e-01 6.78e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 3.55e-01 1.26e-01 5.98e-01
PEXOPHAGY 11 4.71e-01 1.26e-01 6.79e-01
SIGNALING BY GPCR 487 2.25e-06 1.25e-01 1.02e-04
FORMATION OF INCISION COMPLEX IN GG NER 43 1.56e-01 1.25e-01 3.71e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 27 2.61e-01 -1.25e-01 5.02e-01
TIE2 SIGNALING 17 3.73e-01 1.25e-01 6.07e-01
FORMATION OF THE CORNIFIED ENVELOPE 32 2.23e-01 1.24e-01 4.60e-01
JOSEPHIN DOMAIN DUBS 11 4.75e-01 1.24e-01 6.80e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 3.24e-01 1.24e-01 5.69e-01
TRANSLESION SYNTHESIS BY POLK 17 3.75e-01 -1.24e-01 6.07e-01
SIGNALING BY ERBB4 57 1.05e-01 1.24e-01 2.85e-01
DISEASES OF IMMUNE SYSTEM 25 2.83e-01 -1.24e-01 5.25e-01
PROGRAMMED CELL DEATH 186 3.60e-03 1.24e-01 2.73e-02
RHOBTB GTPASE CYCLE 35 2.05e-01 1.24e-01 4.38e-01
RHOV GTPASE CYCLE 33 2.20e-01 1.24e-01 4.57e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 4.99e-01 1.23e-01 7.04e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 62 9.34e-02 1.23e-01 2.64e-01
GLYCOLYSIS 67 8.15e-02 1.23e-01 2.39e-01
REGULATION OF FZD BY UBIQUITINATION 19 3.55e-01 1.22e-01 5.98e-01
HS GAG DEGRADATION 20 3.43e-01 1.22e-01 5.86e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 3.00e-01 -1.22e-01 5.47e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 288 3.76e-04 1.22e-01 5.21e-03
RESPIRATORY ELECTRON TRANSPORT 102 3.36e-02 -1.22e-01 1.30e-01
CHROMATIN MODIFYING ENZYMES 223 1.77e-03 -1.22e-01 1.68e-02
REGULATION OF IFNA SIGNALING 12 4.67e-01 -1.21e-01 6.77e-01
MITOTIC SPINDLE CHECKPOINT 97 3.96e-02 1.21e-01 1.45e-01
APOPTOSIS 164 7.63e-03 1.21e-01 4.78e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 68 8.58e-02 1.21e-01 2.48e-01
PYRIMIDINE SALVAGE 10 5.10e-01 1.20e-01 7.11e-01
CONDENSATION OF PROPHASE CHROMOSOMES 31 2.47e-01 -1.20e-01 4.88e-01
ACTIVATION OF SMO 16 4.05e-01 1.20e-01 6.24e-01
RHO GTPASE EFFECTORS 253 1.05e-03 1.20e-01 1.13e-02
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 3.20e-01 1.20e-01 5.64e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 4.62e-02 1.20e-01 1.63e-01
OTHER INTERLEUKIN SIGNALING 20 3.56e-01 1.19e-01 5.98e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 5.14e-01 1.19e-01 7.13e-01
DNA DAMAGE RECOGNITION IN GG NER 38 2.03e-01 1.19e-01 4.36e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 3.24e-01 -1.19e-01 5.69e-01
DISEASES OF METABOLISM 197 4.19e-03 1.18e-01 3.08e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 3.48e-01 1.18e-01 5.90e-01
SIGNALING BY WNT IN CANCER 31 2.55e-01 1.18e-01 4.99e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 3.49e-01 1.18e-01 5.90e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 2.35e-01 1.18e-01 4.75e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 4.99e-01 1.18e-01 7.04e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 14 4.46e-01 -1.18e-01 6.59e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 5.00e-01 1.17e-01 7.04e-01
TELOMERE EXTENSION BY TELOMERASE 22 3.46e-01 1.16e-01 5.88e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 2.80e-01 1.16e-01 5.22e-01
METABOLISM OF FOLATE AND PTERINES 15 4.37e-01 1.16e-01 6.54e-01
TRIGLYCERIDE METABOLISM 24 3.27e-01 1.16e-01 5.70e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 15 4.39e-01 -1.15e-01 6.55e-01
METABOLISM OF VITAMINS AND COFACTORS 152 1.43e-02 1.15e-01 7.22e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 2.59e-01 1.15e-01 5.02e-01
TNFR2 NON CANONICAL NF KB PATHWAY 79 7.77e-02 1.15e-01 2.31e-01
SHC MEDIATED CASCADE FGFR4 13 4.73e-01 1.15e-01 6.80e-01
M PHASE 344 2.63e-04 1.15e-01 4.00e-03
INFLUENZA INFECTION 146 1.70e-02 -1.15e-01 8.00e-02
DNA DOUBLE STRAND BREAK REPAIR 140 1.98e-02 -1.14e-01 8.85e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 3.44e-01 1.14e-01 5.87e-01
MITOTIC G2 G2 M PHASES 184 7.80e-03 1.14e-01 4.81e-02
GENE SILENCING BY RNA 86 6.84e-02 -1.14e-01 2.13e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.47e-01 -1.13e-01 5.88e-01
MITOTIC TELOPHASE CYTOKINESIS 13 4.81e-01 -1.13e-01 6.84e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 3.82e-01 -1.13e-01 6.09e-01
MAPK6 MAPK4 SIGNALING 83 7.69e-02 1.12e-01 2.30e-01
SIGNALING BY SCF KIT 41 2.13e-01 1.12e-01 4.51e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 53 1.59e-01 1.12e-01 3.77e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 284 1.22e-03 1.12e-01 1.29e-02
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.96e-01 1.11e-01 4.30e-01
COSTIMULATION BY THE CD28 FAMILY 51 1.71e-01 1.11e-01 3.94e-01
BILE ACID AND BILE SALT METABOLISM 26 3.28e-01 1.11e-01 5.72e-01
INWARDLY RECTIFYING K CHANNELS 32 2.78e-01 1.11e-01 5.21e-01
KERATINIZATION 33 2.72e-01 1.11e-01 5.13e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 5.07e-01 -1.11e-01 7.10e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 3.41e-01 1.10e-01 5.84e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 3.72e-01 -1.10e-01 6.07e-01
INTERLEUKIN 1 FAMILY SIGNALING 123 3.59e-02 1.10e-01 1.34e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 3.07e-01 -1.10e-01 5.52e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 3.25e-01 1.09e-01 5.69e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 4.50e-01 1.09e-01 6.62e-01
SIGNALING BY FGFR2 IN DISEASE 37 2.52e-01 -1.09e-01 4.94e-01
HEMOSTASIS 478 4.81e-05 1.09e-01 1.05e-03
TRANSPORT OF SMALL MOLECULES 584 7.99e-06 1.08e-01 2.48e-04
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 102 5.92e-02 1.08e-01 1.92e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 348 5.91e-04 1.07e-01 7.25e-03
CELL CYCLE MITOTIC 479 6.17e-05 1.07e-01 1.21e-03
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 4.08e-01 -1.07e-01 6.27e-01
PTEN REGULATION 133 3.35e-02 1.07e-01 1.30e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 1.85e-01 -1.06e-01 4.16e-01
RHOBTB1 GTPASE CYCLE 23 3.78e-01 1.06e-01 6.07e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 3.07e-02 1.06e-01 1.22e-01
SIGNALING BY WNT 274 2.66e-03 1.06e-01 2.24e-02
FLT3 SIGNALING IN DISEASE 28 3.35e-01 -1.05e-01 5.78e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 2.45e-01 1.05e-01 4.85e-01
BIOTIN TRANSPORT AND METABOLISM 11 5.47e-01 -1.05e-01 7.40e-01
SIGNALING BY PTK6 50 2.03e-01 1.04e-01 4.36e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 2.40e-01 -1.04e-01 4.80e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 3.19e-01 -1.03e-01 5.64e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 2.03e-01 1.03e-01 4.36e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 5.20e-01 -1.03e-01 7.17e-01
RUNX3 REGULATES NOTCH SIGNALING 13 5.21e-01 -1.03e-01 7.17e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 15 4.90e-01 1.03e-01 6.94e-01
INITIAL TRIGGERING OF COMPLEMENT 12 5.38e-01 1.03e-01 7.35e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 30 3.32e-01 1.02e-01 5.75e-01
SENSORY PERCEPTION 162 2.56e-02 -1.02e-01 1.06e-01
RHOH GTPASE CYCLE 37 2.86e-01 1.01e-01 5.26e-01
SIGNALING BY NOTCH4 83 1.11e-01 1.01e-01 2.93e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 2.63e-01 1.01e-01 5.03e-01
ECM PROTEOGLYCANS 68 1.51e-01 -1.01e-01 3.69e-01
PHASE 0 RAPID DEPOLARISATION 28 3.58e-01 -1.00e-01 6.00e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 2.39e-01 -1.00e-01 4.79e-01
INTERLEUKIN 7 SIGNALING 19 4.49e-01 -1.00e-01 6.62e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 119 5.91e-02 1.00e-01 1.92e-01
RAC2 GTPASE CYCLE 87 1.07e-01 1.00e-01 2.87e-01
MEIOTIC RECOMBINATION 42 2.64e-01 -9.97e-02 5.03e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 5.19e-01 -9.95e-02 7.17e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 4.30e-01 9.94e-02 6.49e-01
RHOG GTPASE CYCLE 74 1.40e-01 9.93e-02 3.49e-01
VIRAL MESSENGER RNA SYNTHESIS 42 2.67e-01 -9.91e-02 5.08e-01
FANCONI ANEMIA PATHWAY 36 3.06e-01 -9.86e-02 5.51e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 5.72e-01 9.84e-02 7.61e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 1.96e-01 9.83e-02 4.29e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 3.87e-01 9.80e-02 6.13e-01
SIGNALING BY CSF3 G CSF 29 3.62e-01 9.79e-02 6.02e-01
INFLAMMASOMES 19 4.63e-01 -9.74e-02 6.76e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 4.11e-01 9.69e-02 6.28e-01
METABOLISM OF STEROID HORMONES 22 4.32e-01 9.68e-02 6.49e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 4.03e-01 9.66e-02 6.24e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 14 5.33e-01 9.62e-02 7.31e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 3.12e-01 -9.61e-02 5.55e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 5.07e-01 9.58e-02 7.10e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 5.67e-01 9.55e-02 7.56e-01
UB SPECIFIC PROCESSING PROTEASES 169 3.34e-02 9.50e-02 1.30e-01
HEME BIOSYNTHESIS 13 5.55e-01 9.46e-02 7.49e-01
DNA DAMAGE BYPASS 47 2.63e-01 -9.44e-02 5.03e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 6.86e-02 -9.44e-02 2.13e-01
G PROTEIN BETA GAMMA SIGNALLING 31 3.64e-01 9.42e-02 6.02e-01
NGF STIMULATED TRANSCRIPTION 36 3.30e-01 9.39e-02 5.73e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 5.90e-01 -9.38e-02 7.77e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 5.16e-01 9.38e-02 7.14e-01
ONCOGENIC MAPK SIGNALING 77 1.55e-01 9.37e-02 3.71e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 5.92e-01 -9.32e-02 7.78e-01
TRANSLATION 287 6.66e-03 9.32e-02 4.30e-02
REPRODUCTION 81 1.49e-01 -9.28e-02 3.66e-01
SCAVENGING BY CLASS A RECEPTORS 14 5.48e-01 9.27e-02 7.40e-01
CELL CELL JUNCTION ORGANIZATION 48 2.67e-01 9.27e-02 5.08e-01
REGULATED PROTEOLYSIS OF P75NTR 12 5.79e-01 9.26e-02 7.67e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 4.66e-01 9.19e-02 6.77e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 2.31e-01 -9.18e-02 4.71e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 4.66e-01 9.18e-02 6.77e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 4.01e-01 -9.18e-02 6.24e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 4.03e-01 9.14e-02 6.24e-01
SIGNALING BY INSULIN RECEPTOR 65 2.03e-01 9.13e-02 4.36e-01
INTERLEUKIN 17 SIGNALING 68 1.93e-01 9.12e-02 4.26e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 65 2.04e-01 -9.12e-02 4.37e-01
RNA POLYMERASE I PROMOTER ESCAPE 51 2.61e-01 -9.10e-02 5.02e-01
RHOJ GTPASE CYCLE 54 2.48e-01 9.10e-02 4.89e-01
HIV ELONGATION ARREST AND RECOVERY 32 3.73e-01 -9.09e-02 6.07e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 69 1.92e-01 -9.09e-02 4.24e-01
NICOTINAMIDE SALVAGING 14 5.58e-01 -9.05e-02 7.51e-01
SIGNALING BY NTRK2 TRKB 24 4.43e-01 9.04e-02 6.57e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 3.07e-01 9.01e-02 5.51e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 6.23e-01 8.99e-02 7.98e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 4.87e-01 8.98e-02 6.91e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 284 9.58e-03 8.95e-02 5.44e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 4.78e-01 8.95e-02 6.82e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.87e-01 -8.94e-02 4.18e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 77 1.75e-01 8.94e-02 4.01e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 2.32e-01 8.93e-02 4.72e-01
CELL CYCLE CHECKPOINTS 245 1.65e-02 8.90e-02 7.89e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT 192 3.42e-02 8.87e-02 1.31e-01
NEUROTRANSMITTER RELEASE CYCLE 48 2.89e-01 8.86e-02 5.29e-01
NEGATIVE REGULATION OF FLT3 14 5.66e-01 -8.85e-02 7.56e-01
SIGNALING BY FGFR1 44 3.10e-01 8.85e-02 5.53e-01
BASE EXCISION REPAIR AP SITE FORMATION 33 3.83e-01 -8.78e-02 6.09e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 4.48e-01 -8.76e-02 6.62e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 6.16e-01 8.74e-02 7.95e-01
MITOTIC PROPHASE 98 1.36e-01 8.73e-02 3.40e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 4.01e-01 -8.72e-02 6.24e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 181 4.33e-02 8.72e-02 1.56e-01
TRAFFICKING OF AMPA RECEPTORS 31 4.02e-01 8.70e-02 6.24e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.74e-01 8.69e-02 5.15e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 6.19e-01 -8.66e-02 7.96e-01
INTEGRIN SIGNALING 24 4.63e-01 8.65e-02 6.76e-01
RESOLUTION OF ABASIC SITES AP SITES 38 3.59e-01 -8.60e-02 6.01e-01
G PROTEIN ACTIVATION 23 4.76e-01 8.59e-02 6.80e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 4.01e-01 -8.58e-02 6.24e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 3.91e-01 8.51e-02 6.16e-01
MUSCLE CONTRACTION 161 6.33e-02 -8.49e-02 2.00e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 5.97e-01 -8.47e-02 7.82e-01
MITOTIC PROMETAPHASE 177 5.22e-02 8.47e-02 1.76e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 462 1.90e-03 8.45e-02 1.77e-02
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 12 6.14e-01 8.42e-02 7.95e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 5.16e-01 8.39e-02 7.14e-01
PI 3K CASCADE FGFR4 13 6.01e-01 -8.37e-02 7.83e-01
ADHERENS JUNCTIONS INTERACTIONS 30 4.32e-01 8.29e-02 6.49e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 5.92e-01 8.26e-02 7.78e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 4.42e-01 8.26e-02 6.57e-01
SIGNALING BY INTERLEUKINS 349 8.51e-03 8.21e-02 5.06e-02
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 1.94e-01 8.21e-02 4.26e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 6.53e-01 8.20e-02 8.18e-01
RA BIOSYNTHESIS PATHWAY 13 6.11e-01 -8.14e-02 7.94e-01
NEPHRIN FAMILY INTERACTIONS 23 5.00e-01 8.12e-02 7.04e-01
TOLL LIKE RECEPTOR CASCADES 138 1.02e-01 8.07e-02 2.81e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 5.43e-01 8.06e-02 7.37e-01
TRNA PROCESSING IN THE NUCLEUS 56 2.97e-01 8.06e-02 5.43e-01
HDR THROUGH MMEJ ALT NHEJ 10 6.59e-01 -8.05e-02 8.21e-01
CELL CYCLE 598 8.01e-04 8.05e-02 9.16e-03
HCMV INFECTION 107 1.52e-01 8.02e-02 3.69e-01
PLATELET CALCIUM HOMEOSTASIS 26 4.80e-01 -8.00e-02 6.84e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 4.57e-01 7.99e-02 6.70e-01
RHOD GTPASE CYCLE 51 3.24e-01 7.98e-02 5.69e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 5.08e-01 7.97e-02 7.10e-01
ENDOGENOUS STEROLS 20 5.37e-01 -7.97e-02 7.35e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 74 2.40e-01 -7.90e-02 4.80e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 5.14e-01 -7.87e-02 7.13e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 3.01e-01 7.85e-02 5.49e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 36 4.17e-01 -7.81e-02 6.35e-01
O LINKED GLYCOSYLATION 85 2.15e-01 7.79e-02 4.51e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 1.92e-01 7.79e-02 4.24e-01
MAP2K AND MAPK ACTIVATION 36 4.19e-01 7.78e-02 6.37e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 183 7.28e-02 -7.70e-02 2.21e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 6.18e-01 7.69e-02 7.96e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 6.32e-01 -7.66e-02 8.03e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 1.17e-02 7.66e-02 6.34e-02
METABOLISM OF COFACTORS 19 5.64e-01 7.65e-02 7.56e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 44 3.81e-01 7.64e-02 6.09e-01
IRS MEDIATED SIGNALLING 41 3.98e-01 -7.64e-02 6.24e-01
INFECTIOUS DISEASE 739 4.47e-04 7.62e-02 5.98e-03
MYOGENESIS 25 5.11e-01 -7.59e-02 7.11e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 5.48e-01 7.58e-02 7.40e-01
RAC3 GTPASE CYCLE 90 2.20e-01 7.49e-02 4.57e-01
IRAK4 DEFICIENCY TLR2 4 14 6.29e-01 -7.45e-02 8.02e-01
RND3 GTPASE CYCLE 38 4.27e-01 7.44e-02 6.46e-01
PRE NOTCH EXPRESSION AND PROCESSING 68 2.90e-01 -7.42e-02 5.32e-01
FOXO MEDIATED TRANSCRIPTION 57 3.34e-01 -7.41e-02 5.78e-01
RHO GTPASES ACTIVATE CIT 18 5.88e-01 -7.38e-02 7.76e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 4.04e-01 7.35e-02 6.24e-01
P38MAPK EVENTS 13 6.48e-01 7.31e-02 8.15e-01
G ALPHA S SIGNALLING EVENTS 108 1.90e-01 7.30e-02 4.22e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 15 6.27e-01 7.24e-02 8.01e-01
TRP CHANNELS 20 5.75e-01 -7.23e-02 7.64e-01
MICRORNA MIRNA BIOGENESIS 24 5.40e-01 -7.22e-02 7.36e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 4.50e-01 -7.17e-02 6.62e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 5.99e-01 -7.17e-02 7.82e-01
RHOU GTPASE CYCLE 34 4.72e-01 7.14e-02 6.79e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 35 4.66e-01 -7.12e-02 6.77e-01
DEUBIQUITINATION 243 5.68e-02 7.10e-02 1.87e-01
MEIOSIS 68 3.12e-01 -7.10e-02 5.55e-01
ONCOGENE INDUCED SENESCENCE 32 4.88e-01 7.09e-02 6.91e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 6.24e-01 -7.09e-02 7.98e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 2.60e-01 7.07e-02 5.02e-01
RNA POLYMERASE I TRANSCRIPTION 71 3.04e-01 -7.06e-02 5.50e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 630 2.58e-03 7.06e-02 2.19e-02
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 97 2.33e-01 7.01e-02 4.73e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 33 4.87e-01 7.00e-02 6.91e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 60 3.49e-01 -6.99e-02 5.90e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 6.76e-01 6.98e-02 8.33e-01
HATS ACETYLATE HISTONES 97 2.36e-01 -6.97e-02 4.77e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 3.78e-01 -6.94e-02 6.07e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 6.78e-01 -6.92e-02 8.33e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 4.41e-01 -6.87e-02 6.57e-01
LEISHMANIA INFECTION 199 9.66e-02 6.84e-02 2.70e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 16 6.37e-01 6.82e-02 8.06e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 6.97e-01 6.79e-02 8.48e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 5.66e-01 -6.76e-02 7.56e-01
GAB1 SIGNALOSOME 14 6.61e-01 -6.76e-02 8.23e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 6.85e-01 6.76e-02 8.40e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 5.98e-01 6.65e-02 7.82e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.78e-01 6.63e-02 6.07e-01
SIGNALING BY NOTCH2 33 5.10e-01 6.62e-02 7.11e-01
MAPK FAMILY SIGNALING CASCADES 290 5.28e-02 6.62e-02 1.77e-01
POTASSIUM CHANNELS 90 2.79e-01 6.60e-02 5.22e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 6.93e-01 6.58e-02 8.45e-01
INTERLEUKIN 37 SIGNALING 18 6.30e-01 6.57e-02 8.02e-01
THE PHOTOTRANSDUCTION CASCADE 22 5.94e-01 -6.56e-02 7.79e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 33 5.15e-01 6.55e-02 7.14e-01
RNA POLYMERASE III TRANSCRIPTION 41 4.70e-01 -6.52e-02 6.79e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 6.33e-01 6.50e-02 8.03e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 6.66e-01 -6.45e-02 8.24e-01
RHOA GTPASE CYCLE 141 1.88e-01 6.42e-02 4.19e-01
PI 3K CASCADE FGFR3 13 6.89e-01 -6.40e-02 8.43e-01
PLATELET AGGREGATION PLUG FORMATION 32 5.33e-01 6.38e-02 7.31e-01
POTENTIAL THERAPEUTICS FOR SARS 77 3.34e-01 6.37e-02 5.78e-01
METABOLISM OF PORPHYRINS 19 6.31e-01 6.36e-02 8.02e-01
CRISTAE FORMATION 31 5.40e-01 6.36e-02 7.36e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 42 4.76e-01 -6.36e-02 6.80e-01
DUAL INCISION IN TC NER 65 3.76e-01 -6.35e-02 6.07e-01
SIGNALING BY BMP 25 5.84e-01 6.33e-02 7.73e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 5.99e-01 -6.33e-02 7.82e-01
MEIOTIC SYNAPSIS 44 4.68e-01 -6.33e-02 6.77e-01
LONG TERM POTENTIATION 23 6.00e-01 6.32e-02 7.82e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 607 8.06e-03 6.32e-02 4.89e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 7.06e-01 6.29e-02 8.56e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 3.17e-01 6.28e-02 5.62e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 4.05e-01 -6.16e-02 6.24e-01
CARDIAC CONDUCTION 107 2.71e-01 -6.16e-02 5.13e-01
CELL JUNCTION ORGANIZATION 73 3.64e-01 6.15e-02 6.02e-01
HIV LIFE CYCLE 142 2.07e-01 6.15e-02 4.41e-01
G2 M CHECKPOINTS 136 2.16e-01 6.14e-02 4.53e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 4.88e-01 -6.12e-02 6.91e-01
BASE EXCISION REPAIR 61 4.09e-01 -6.11e-02 6.28e-01
SEMAPHORIN INTERACTIONS 64 3.99e-01 -6.10e-02 6.24e-01
SELENOAMINO ACID METABOLISM 109 2.74e-01 -6.07e-02 5.15e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 7.41e-01 6.03e-02 8.70e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 7.42e-01 -6.01e-02 8.70e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 2.81e-01 6.01e-02 5.22e-01
SIGNALING BY FGFR 74 3.74e-01 5.98e-02 6.07e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 7.22e-01 -5.93e-02 8.67e-01
DNA REPAIR 296 8.12e-02 -5.90e-02 2.39e-01
PLASMA LIPOPROTEIN ASSEMBLY 12 7.24e-01 5.88e-02 8.67e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 6.49e-01 5.88e-02 8.15e-01
SODIUM CALCIUM EXCHANGERS 10 7.48e-01 -5.87e-02 8.72e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 7.37e-01 5.85e-02 8.68e-01
PHOSPHORYLATION OF THE APC C 17 6.79e-01 5.81e-02 8.33e-01
REGULATION OF SIGNALING BY CBL 22 6.38e-01 5.80e-02 8.06e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.43e-01 5.78e-02 7.37e-01
ANTIGEN PROCESSING CROSS PRESENTATION 96 3.29e-01 5.77e-02 5.72e-01
COLLAGEN DEGRADATION 52 4.74e-01 -5.74e-02 6.80e-01
CELL CELL COMMUNICATION 106 3.09e-01 5.72e-02 5.53e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 39 5.37e-01 -5.71e-02 7.35e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 5.56e-01 5.68e-02 7.49e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 12 7.37e-01 -5.61e-02 8.68e-01
RHO GTPASES ACTIVATE KTN1 11 7.48e-01 5.60e-02 8.72e-01
RRNA PROCESSING 195 1.79e-01 -5.58e-02 4.08e-01
SUMOYLATION 168 2.13e-01 -5.57e-02 4.51e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 6.15e-01 -5.50e-02 7.95e-01
DUAL INCISION IN GG NER 41 5.43e-01 -5.49e-02 7.37e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 6.17e-01 5.47e-02 7.96e-01
COLLAGEN FORMATION 79 4.02e-01 -5.45e-02 6.24e-01
DEATH RECEPTOR SIGNALLING 132 2.82e-01 5.43e-02 5.24e-01
SIGNALING BY TGFB FAMILY MEMBERS 96 3.63e-01 5.37e-02 6.02e-01
RET SIGNALING 38 5.69e-01 5.34e-02 7.58e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 4.64e-01 -5.34e-02 6.76e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 94 3.73e-01 5.32e-02 6.07e-01
APOPTOTIC EXECUTION PHASE 45 5.37e-01 5.31e-02 7.35e-01
MITOCHONDRIAL TRANSLATION 93 3.77e-01 5.31e-02 6.07e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 7.23e-01 5.29e-02 8.67e-01
UCH PROTEINASES 90 3.87e-01 5.28e-02 6.13e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 6.76e-01 -5.28e-02 8.33e-01
SIGNALING BY FGFR2 63 4.73e-01 5.23e-02 6.80e-01
NUCLEAR ENVELOPE BREAKDOWN 49 5.28e-01 5.21e-02 7.26e-01
G2 M DNA DAMAGE CHECKPOINT 69 4.56e-01 -5.19e-02 6.70e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 7.77e-01 5.18e-02 8.94e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 7.39e-01 5.13e-02 8.68e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 6.65e-01 5.11e-02 8.24e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 7.70e-01 5.10e-02 8.89e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 92 3.98e-01 5.10e-02 6.24e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 7.09e-01 -5.09e-02 8.58e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 4.11e-01 -5.07e-02 6.28e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 6.09e-01 5.07e-02 7.92e-01
TRIGLYCERIDE BIOSYNTHESIS 10 7.82e-01 -5.05e-02 8.98e-01
MET PROMOTES CELL MOTILITY 39 5.87e-01 -5.03e-02 7.75e-01
COMPLEMENT CASCADE 26 6.62e-01 4.95e-02 8.23e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 4.17e-01 4.93e-02 6.35e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 5.86e-01 4.92e-02 7.75e-01
EFFECTS OF PIP2 HYDROLYSIS 27 6.59e-01 -4.91e-02 8.21e-01
MRNA SPLICING 188 2.49e-01 4.88e-02 4.90e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 83 4.42e-01 4.88e-02 6.57e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 62 5.08e-01 -4.87e-02 7.10e-01
PI3K AKT SIGNALING IN CANCER 91 4.23e-01 4.87e-02 6.42e-01
EUKARYOTIC TRANSLATION INITIATION 115 3.68e-01 -4.86e-02 6.06e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 7.82e-01 4.82e-02 8.98e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 7.56e-01 4.80e-02 8.77e-01
RHOC GTPASE CYCLE 73 4.80e-01 4.78e-02 6.84e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 6.58e-01 -4.75e-02 8.21e-01
CYTOPROTECTION BY HMOX1 119 3.72e-01 4.74e-02 6.07e-01
SURFACTANT METABOLISM 16 7.43e-01 4.74e-02 8.70e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 83 4.59e-01 4.70e-02 6.73e-01
VISUAL PHOTOTRANSDUCTION 62 5.23e-01 4.69e-02 7.20e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 50 5.74e-01 -4.60e-02 7.63e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 20 7.22e-01 4.60e-02 8.67e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 4.11e-01 -4.58e-02 6.28e-01
BASIGIN INTERACTIONS 22 7.12e-01 4.55e-02 8.61e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 4.43e-01 4.53e-02 6.57e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 6.34e-01 -4.52e-02 8.03e-01
RHO GTPASES ACTIVATE ROCKS 19 7.33e-01 -4.52e-02 8.68e-01
ERBB2 REGULATES CELL MOTILITY 14 7.71e-01 4.49e-02 8.90e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 107 4.23e-01 -4.48e-02 6.42e-01
REGULATION OF TP53 ACTIVITY 152 3.41e-01 4.48e-02 5.84e-01
SLC TRANSPORTER DISORDERS 76 5.02e-01 4.45e-02 7.06e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 6.68e-01 -4.45e-02 8.27e-01
NICOTINATE METABOLISM 23 7.13e-01 4.44e-02 8.61e-01
STIMULI SENSING CHANNELS 76 5.10e-01 -4.38e-02 7.11e-01
RND1 GTPASE CYCLE 38 6.42e-01 4.35e-02 8.09e-01
ERK MAPK TARGETS 22 7.26e-01 4.31e-02 8.67e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 12 7.96e-01 4.30e-02 9.06e-01
RHO GTPASES ACTIVATE PAKS 21 7.34e-01 4.29e-02 8.68e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 7.53e-01 -4.29e-02 8.76e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 7.82e-01 4.27e-02 8.98e-01
SIGNALING BY ACTIVIN 11 8.10e-01 4.19e-02 9.13e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 150 3.77e-01 4.19e-02 6.07e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 7.94e-01 -4.17e-02 9.06e-01
EARLY PHASE OF HIV LIFE CYCLE 13 7.95e-01 4.16e-02 9.06e-01
SIGNALING BY ERBB2 48 6.19e-01 4.16e-02 7.96e-01
RHO GTPASE CYCLE 423 1.44e-01 4.15e-02 3.58e-01
EXTRACELLULAR MATRIX ORGANIZATION 250 2.60e-01 -4.14e-02 5.02e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 7.34e-01 -4.09e-02 8.68e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 11 8.15e-01 -4.08e-02 9.16e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 7.00e-01 4.06e-02 8.50e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 7.25e-01 -4.06e-02 8.67e-01
SIGNALING BY NOTCH1 75 5.47e-01 4.02e-02 7.40e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 33 6.91e-01 -4.00e-02 8.44e-01
ELASTIC FIBRE FORMATION 38 6.72e-01 -3.96e-02 8.31e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 5.61e-01 3.91e-02 7.55e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 7.32e-01 3.89e-02 8.68e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 33 6.99e-01 3.89e-02 8.50e-01
REGULATION OF BETA CELL DEVELOPMENT 30 7.14e-01 -3.87e-02 8.62e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 5.66e-01 -3.86e-02 7.56e-01
LGI ADAM INTERACTIONS 14 8.04e-01 3.84e-02 9.11e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 50 6.40e-01 -3.82e-02 8.07e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 7.39e-01 3.77e-02 8.68e-01
SMOOTH MUSCLE CONTRACTION 33 7.08e-01 -3.77e-02 8.58e-01
VOLTAGE GATED POTASSIUM CHANNELS 38 6.88e-01 3.77e-02 8.42e-01
CHROMOSOME MAINTENANCE 106 5.04e-01 -3.75e-02 7.08e-01
MRNA CAPPING 29 7.27e-01 3.74e-02 8.67e-01
SIGNALING BY ERYTHROPOIETIN 24 7.54e-01 -3.70e-02 8.76e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 7.49e-01 3.70e-02 8.72e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 6.26e-01 3.67e-02 8.00e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 6.40e-01 -3.65e-02 8.07e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 8.34e-01 -3.64e-02 9.22e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 8.20e-01 -3.64e-02 9.17e-01
SIGNALING BY MET 74 5.90e-01 3.63e-02 7.77e-01
POLYMERASE SWITCHING 14 8.15e-01 -3.62e-02 9.16e-01
CROSSLINKING OF COLLAGEN FIBRILS 15 8.09e-01 -3.61e-02 9.13e-01
NRAGE SIGNALS DEATH THROUGH JNK 54 6.48e-01 -3.60e-02 8.15e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 8.45e-01 -3.57e-02 9.24e-01
SIGNALING BY LEPTIN 10 8.45e-01 -3.57e-02 9.24e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 13 8.24e-01 3.56e-02 9.20e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 7.55e-01 -3.54e-02 8.77e-01
AMYLOID FIBER FORMATION 62 6.31e-01 -3.52e-02 8.02e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 7.91e-01 -3.51e-02 9.04e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 8.41e-01 3.49e-02 9.24e-01
DNA STRAND ELONGATION 32 7.34e-01 3.47e-02 8.68e-01
SIGNALING BY PDGF 56 6.54e-01 -3.47e-02 8.18e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 8.11e-01 -3.46e-02 9.13e-01
FLT3 SIGNALING 36 7.20e-01 -3.46e-02 8.67e-01
CELLULAR HEXOSE TRANSPORT 12 8.36e-01 3.45e-02 9.22e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 3.63e-01 3.44e-02 6.02e-01
SIGNALING BY FGFR2 IIIA TM 19 7.95e-01 -3.44e-02 9.06e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 7.29e-01 3.39e-02 8.67e-01
METABOLISM OF AMINE DERIVED HORMONES 10 8.53e-01 3.39e-02 9.29e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 87 5.85e-01 3.39e-02 7.75e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 6.90e-01 -3.36e-02 8.43e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 73 6.20e-01 -3.36e-02 7.97e-01
MRNA SPLICING MINOR PATHWAY 52 6.78e-01 3.33e-02 8.33e-01
HCMV EARLY EVENTS 84 6.01e-01 3.30e-02 7.83e-01
SIGNALING BY NOTCH 193 4.37e-01 3.25e-02 6.54e-01
TELOMERE MAINTENANCE 82 6.14e-01 -3.22e-02 7.95e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 7.61e-01 3.21e-02 8.81e-01
NUCLEOTIDE EXCISION REPAIR 110 5.63e-01 3.19e-02 7.56e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 110 5.64e-01 -3.18e-02 7.56e-01
HCMV LATE EVENTS 69 6.50e-01 -3.16e-02 8.15e-01
RND2 GTPASE CYCLE 39 7.39e-01 3.09e-02 8.68e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 6.84e-01 -3.06e-02 8.40e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 7.48e-01 -3.05e-02 8.72e-01
HIV TRANSCRIPTION INITIATION 45 7.25e-01 -3.04e-02 8.67e-01
MITOCHONDRIAL BIOGENESIS 92 6.15e-01 -3.03e-02 7.95e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 7.91e-01 3.00e-02 9.04e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 8.18e-01 2.98e-02 9.16e-01
CA2 PATHWAY 59 6.93e-01 2.97e-02 8.45e-01
INSULIN RECEPTOR SIGNALLING CASCADE 46 7.28e-01 -2.97e-02 8.67e-01
SIGNALING BY NUCLEAR RECEPTORS 229 4.44e-01 2.94e-02 6.57e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 23 8.07e-01 -2.94e-02 9.13e-01
EXTENSION OF TELOMERES 49 7.22e-01 2.94e-02 8.67e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 48 7.26e-01 -2.93e-02 8.67e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 8.30e-01 2.92e-02 9.21e-01
NONHOMOLOGOUS END JOINING NHEJ 46 7.32e-01 -2.92e-02 8.68e-01
REGULATED NECROSIS 46 7.35e-01 2.88e-02 8.68e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 8.08e-01 2.87e-02 9.13e-01
OXIDATIVE STRESS INDUCED SENESCENCE 82 6.57e-01 -2.84e-02 8.20e-01
SIGNALING BY KIT IN DISEASE 20 8.27e-01 2.82e-02 9.21e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 6.77e-01 2.79e-02 8.33e-01
PREGNENOLONE BIOSYNTHESIS 12 8.69e-01 -2.75e-02 9.38e-01
LAGGING STRAND SYNTHESIS 20 8.34e-01 -2.70e-02 9.22e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 18 8.45e-01 2.66e-02 9.24e-01
TRANSLESION SYNTHESIS BY POLH 19 8.43e-01 -2.63e-02 9.24e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 8.60e-01 2.62e-02 9.34e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 7.76e-01 2.57e-02 8.94e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 8.46e-01 2.57e-02 9.25e-01
NEUREXINS AND NEUROLIGINS 54 7.44e-01 2.57e-02 8.71e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 8.17e-01 -2.53e-02 9.16e-01
RNA POLYMERASE III CHAIN ELONGATION 18 8.53e-01 -2.52e-02 9.29e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 32 8.09e-01 2.47e-02 9.13e-01
CIRCADIAN CLOCK 68 7.28e-01 -2.44e-02 8.67e-01
FRS MEDIATED FGFR1 SIGNALING 18 8.58e-01 2.43e-02 9.33e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 8.95e-01 -2.41e-02 9.46e-01
SIGNALING BY FGFR1 IN DISEASE 33 8.11e-01 2.41e-02 9.13e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 8.42e-01 2.41e-02 9.24e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 26 8.32e-01 -2.41e-02 9.22e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 8.95e-01 2.40e-02 9.46e-01
METABOLISM OF RNA 645 3.02e-01 2.39e-02 5.49e-01
ION CHANNEL TRANSPORT 143 6.23e-01 2.38e-02 7.98e-01
CELLULAR RESPONSE TO STARVATION 147 6.22e-01 -2.36e-02 7.98e-01
SIGNALING BY FGFR4 IN DISEASE 11 8.94e-01 2.32e-02 9.46e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 12 8.92e-01 2.26e-02 9.46e-01
ACYL CHAIN REMODELLING OF PS 14 8.84e-01 2.26e-02 9.45e-01
ANTIMICROBIAL PEPTIDES 15 8.82e-01 2.22e-02 9.45e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 8.21e-01 -2.21e-02 9.17e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 7.62e-01 -2.21e-02 8.81e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 8.27e-01 2.20e-02 9.21e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 8.65e-01 2.19e-02 9.38e-01
NERVOUS SYSTEM DEVELOPMENT 554 3.80e-01 2.19e-02 6.08e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 8.88e-01 2.18e-02 9.46e-01
FRS MEDIATED FGFR2 SIGNALING 19 8.70e-01 -2.16e-02 9.39e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 8.30e-01 -2.16e-02 9.21e-01
SIGNALING BY NTRK3 TRKC 17 8.78e-01 -2.16e-02 9.43e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 9.09e-01 -2.09e-02 9.52e-01
RHOQ GTPASE CYCLE 58 7.85e-01 2.07e-02 8.99e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 8.37e-01 2.07e-02 9.22e-01
RNA POLYMERASE II TRANSCRIPTION 1098 2.55e-01 -2.05e-02 4.99e-01
CDC42 GTPASE CYCLE 153 6.63e-01 -2.04e-02 8.23e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 93 7.36e-01 2.02e-02 8.68e-01
PLATELET HOMEOSTASIS 78 7.58e-01 2.02e-02 8.78e-01
IRAK1 RECRUITS IKK COMPLEX 14 8.97e-01 2.00e-02 9.47e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 8.81e-01 -1.98e-02 9.45e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 7.63e-01 1.98e-02 8.82e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 6.56e-01 1.97e-02 8.20e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 7.86e-01 -1.95e-02 9.00e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 8.48e-01 -1.93e-02 9.25e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 8.92e-01 1.91e-02 9.46e-01
PYROPTOSIS 21 8.80e-01 1.90e-02 9.45e-01
NETRIN 1 SIGNALING 50 8.16e-01 1.90e-02 9.16e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 48 8.28e-01 -1.81e-02 9.21e-01
SNRNP ASSEMBLY 51 8.25e-01 1.79e-02 9.20e-01
CARNITINE METABOLISM 14 9.08e-01 -1.79e-02 9.52e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 8.33e-01 -1.76e-02 9.22e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 72 7.98e-01 -1.75e-02 9.06e-01
SIGNALING BY EGFR IN CANCER 22 8.88e-01 1.74e-02 9.46e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 7.96e-01 1.69e-02 9.06e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 9.10e-01 -1.68e-02 9.52e-01
NOD1 2 SIGNALING PATHWAY 35 8.65e-01 1.66e-02 9.38e-01
SIGNALING BY ERBB2 IN CANCER 25 8.87e-01 1.65e-02 9.46e-01
DAP12 SIGNALING 24 8.90e-01 -1.63e-02 9.46e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 8.93e-01 -1.62e-02 9.46e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 8.83e-01 -1.60e-02 9.45e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 9.32e-01 -1.57e-02 9.64e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 8.48e-01 -1.52e-02 9.25e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 9.09e-01 -1.52e-02 9.52e-01
HIV TRANSCRIPTION ELONGATION 42 8.67e-01 -1.50e-02 9.38e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 67 8.35e-01 -1.47e-02 9.22e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.73e-01 -1.45e-02 9.41e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 9.16e-01 -1.44e-02 9.56e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 9.23e-01 1.40e-02 9.60e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 9.40e-01 -1.37e-02 9.70e-01
FGFR2 ALTERNATIVE SPLICING 25 9.06e-01 1.36e-02 9.52e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 9.09e-01 -1.36e-02 9.52e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 8.37e-01 1.35e-02 9.22e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 9.21e-01 1.35e-02 9.59e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.95e-01 -1.35e-02 9.46e-01
SYNDECAN INTERACTIONS 27 9.07e-01 1.30e-02 9.52e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 9.41e-01 1.29e-02 9.70e-01
SIGNALING BY FGFR IN DISEASE 57 8.67e-01 -1.28e-02 9.38e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.34e-01 1.27e-02 9.65e-01
SHC MEDIATED CASCADE FGFR1 16 9.31e-01 -1.25e-02 9.64e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 9.09e-01 -1.25e-02 9.52e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 9.48e-01 1.20e-02 9.74e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 9.19e-01 1.15e-02 9.59e-01
TP53 REGULATES METABOLIC GENES 85 8.55e-01 -1.14e-02 9.30e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 9.43e-01 -1.14e-02 9.71e-01
ION HOMEOSTASIS 50 8.91e-01 -1.12e-02 9.46e-01
SIGNALING BY ROBO RECEPTORS 208 7.84e-01 1.10e-02 8.99e-01
PERK REGULATES GENE EXPRESSION 28 9.20e-01 1.09e-02 9.59e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 9.49e-01 -1.06e-02 9.75e-01
METALLOPROTEASE DUBS 27 9.25e-01 1.05e-02 9.61e-01
RHOB GTPASE CYCLE 67 8.83e-01 1.04e-02 9.45e-01
RAC1 GTPASE CYCLE 177 8.17e-01 1.01e-02 9.16e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 9.21e-01 1.01e-02 9.59e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 9.46e-01 -1.00e-02 9.74e-01
DNA DOUBLE STRAND BREAK RESPONSE 55 8.98e-01 1.00e-02 9.47e-01
TRANSCRIPTION OF THE HIV GENOME 67 8.91e-01 9.73e-03 9.46e-01
SENSORY PROCESSING OF SOUND 62 9.03e-01 -8.92e-03 9.52e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 9.33e-01 -8.77e-03 9.65e-01
ESR MEDIATED SIGNALING 172 8.44e-01 8.72e-03 9.24e-01
TRNA PROCESSING 105 8.78e-01 8.70e-03 9.43e-01
ARACHIDONIC ACID METABOLISM 38 9.26e-01 8.67e-03 9.61e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 9.28e-01 -7.76e-03 9.63e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 163 8.68e-01 -7.58e-03 9.38e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 9.15e-01 7.23e-03 9.56e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 542 7.98e-01 -6.43e-03 9.06e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 9.70e-01 5.99e-03 9.90e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.57e-01 -5.72e-03 9.81e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 9.63e-01 5.59e-03 9.85e-01
P75NTR SIGNALS VIA NF KB 15 9.72e-01 -5.17e-03 9.91e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.38e-01 4.91e-03 9.68e-01
TRANSCRIPTIONAL REGULATION BY TP53 343 8.77e-01 4.85e-03 9.43e-01
SIGNALING BY PDGFR IN DISEASE 20 9.70e-01 -4.78e-03 9.90e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 9.51e-01 -4.74e-03 9.76e-01
RHO GTPASES ACTIVATE PKNS 51 9.56e-01 4.49e-03 9.80e-01
DEVELOPMENTAL BIOLOGY 833 8.29e-01 4.43e-03 9.21e-01
SIGNALLING TO RAS 19 9.76e-01 4.00e-03 9.93e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 9.81e-01 3.69e-03 9.94e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 9.78e-01 3.52e-03 9.94e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 9.79e-01 -3.41e-03 9.94e-01
DISEASES OF PROGRAMMED CELL DEATH 58 9.66e-01 -3.28e-03 9.87e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 9.81e-01 3.27e-03 9.94e-01
AURKA ACTIVATION BY TPX2 71 9.63e-01 -3.16e-03 9.85e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 9.76e-01 3.00e-03 9.93e-01
MISMATCH REPAIR 15 9.85e-01 -2.80e-03 9.95e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 9.87e-01 -2.43e-03 9.95e-01
NUCLEAR IMPORT OF REV PROTEIN 32 9.81e-01 2.37e-03 9.94e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 9.86e-01 2.28e-03 9.95e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 9.87e-01 -1.70e-03 9.95e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 9.82e-01 1.69e-03 9.94e-01
PECAM1 INTERACTIONS 12 9.92e-01 1.61e-03 9.99e-01
ION TRANSPORT BY P TYPE ATPASES 50 9.88e-01 -1.27e-03 9.95e-01
REPRESSION OF WNT TARGET GENES 14 9.94e-01 -1.11e-03 1.00e+00
PYRIMIDINE CATABOLISM 10 9.95e-01 1.09e-03 1.00e+00
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 64 9.96e-01 -3.96e-04 1.00e+00
PLASMA LIPOPROTEIN REMODELING 14 9.99e-01 -2.36e-04 1.00e+00
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 9.98e-01 -2.15e-04 1.00e+00
SIGNALING BY NOTCH3 48 9.98e-01 -1.97e-04 1.00e+00
CELLULAR SENESCENCE 146 9.99e-01 8.71e-05 1.00e+00
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.00e+00 1.63e-05 1.00e+00


Detailed Gene set reports



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
340
set FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize 19
pANOVA 9.33e-08
s.dist 0.707
p.adjustANOVA 5.5e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cct6a 8139
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Cct5 7328
Tuba4a 7208
Cct3 7150
Tuba1a 7067
Tcp1 6639
Cct8 6486
Cct4 6252
Tubb3 5842
Cct7 4843
Tuba1c 4485
Cct2 3832
Tubb6 1806
Tuba8 -5577

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a 8139
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Cct5 7328
Tuba4a 7208
Cct3 7150
Tuba1a 7067
Tcp1 6639
Cct8 6486
Cct4 6252
Tubb3 5842
Cct7 4843
Tuba1c 4485
Cct2 3832
Tubb6 1806
Tuba8 -5577


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
47
set ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize 12
pANOVA 0.000265
s.dist 0.608
p.adjustANOVA 0.004



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fads2 8315
Fads1 8229
Elovl1 7473
Hsd17b4 6568
Acox1 6066
Acaa1a 5291
Scp2 3811
Acot8 3545
Acsl1 2715
Elovl5 2632
Elovl2 2613
Abcd1 1865

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fads2 8315
Fads1 8229
Elovl1 7473
Hsd17b4 6568
Acox1 6066
Acaa1a 5291
Scp2 3811
Acot8 3545
Acsl1 2715
Elovl5 2632
Elovl2 2613
Abcd1 1865


GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
398
set GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
setSize 12
pANOVA 0.000567
s.dist 0.575
p.adjustANOVA 0.00704



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mapk3 7701
Gorasp2 7540
Mapk1 7097
Uso1 6853
Rab2a 6470
Rab1b 6316
Rab1a 6145
Ccnb2 5891
Blzf1 4985
Gorasp1 4112
Golga2 -3175
Plk1 -4344

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk3 7701
Gorasp2 7540
Mapk1 7097
Uso1 6853
Rab2a 6470
Rab1b 6316
Rab1a 6145
Ccnb2 5891
Blzf1 4985
Gorasp1 4112
Golga2 -3175
Plk1 -4344


PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
757
set PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
setSize 12
pANOVA 0.000789
s.dist 0.56
p.adjustANOVA 0.00911



Top enriched genes

Top 20 genes
GeneID Gene Rank
Impdh2 7591
Gart 7383
Paics 7071
Adss 6927
Gmps 6784
Atic 6715
Adsl 5423
Adssl1 5346
Impdh1 3125
Ppat 1917
Lhpp 1163
Pfas -5437

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Impdh2 7591
Gart 7383
Paics 7071
Adss 6927
Gmps 6784
Atic 6715
Adsl 5423
Adssl1 5346
Impdh1 3125
Ppat 1917
Lhpp 1163
Pfas -5437


RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
860
set RHOBTB3 ATPASE CYCLE
setSize 10
pANOVA 0.00245
s.dist 0.553
p.adjustANOVA 0.021



Top enriched genes

Top 20 genes
GeneID Gene Rank
Htr7 7894
Ccne1 7431
Rab9b 5924
Cul3 5822
Hgs 5340
Plin3 5265
Lrrc41 4586
Vhl 2253
Rhobtb3 402
Rab9 -457

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Htr7 7894
Ccne1 7431
Rab9b 5924
Cul3 5822
Hgs 5340
Plin3 5265
Lrrc41 4586
Vhl 2253
Rhobtb3 402
Rab9 -457


TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
1138
set TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize 13
pANOVA 0.000836
s.dist 0.535
p.adjustANOVA 0.00938



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Tubb3 5842
Gja1 5105
Tuba1c 4485
Tubb6 1806
Tuba8 -5577
Gjb2 -8878

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Tubb3 5842
Gja1 5105
Tuba1c 4485
Tubb6 1806
Tuba8 -5577
Gjb2 -8878


BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM
92
set BBSOME MEDIATED CARGO TARGETING TO CILIUM
setSize 23
pANOVA 9.28e-06
s.dist 0.534
p.adjustANOVA 0.00028



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mkks 8028
Bbs10 7881
Cct5 7328
Mchr1 7255
Bbs9 7234
Cct3 7150
Arl6 6976
Tcp1 6639
Lztfl1 6504
Cct8 6486
Cct4 6252
Rab3ip 6224
Ttc8 6172
Bbs1 5926
Smo 5053
Bbs7 4516
Cct2 3832
Bbs2 2160
Bbip1 1835
Bbs4 1657

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mkks 8028
Bbs10 7881
Cct5 7328
Mchr1 7255
Bbs9 7234
Cct3 7150
Arl6 6976
Tcp1 6639
Lztfl1 6504
Cct8 6486
Cct4 6252
Rab3ip 6224
Ttc8 6172
Bbs1 5926
Smo 5053
Bbs7 4516
Cct2 3832
Bbs2 2160
Bbip1 1835
Bbs4 1657
Sstr3 -5368
Bbs5 -5698
Bbs12 -5783


CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
154
set CITRIC ACID CYCLE TCA CYCLE
setSize 22
pANOVA 2.49e-05
s.dist 0.519
p.adjustANOVA 0.000636



Top enriched genes

Top 20 genes
GeneID Gene Rank
Idh2 8249
Idh3a 7988
Fh1 7915
Sucla2 6928
Dld 6906
Idh3b 6659
Dlst 6472
Suclg2 5337
Mdh2 5325
Sdhd 5079
Aco2 4730
Idh3g 4298
Sdha 4003
Cs 3839
Ogdh 3656
Suclg1 3555
Nnt 3360
Sdhb 2165
Fahd1 1729
Sdhc 1198

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Idh2 8249
Idh3a 7988
Fh1 7915
Sucla2 6928
Dld 6906
Idh3b 6659
Dlst 6472
Suclg2 5337
Mdh2 5325
Sdhd 5079
Aco2 4730
Idh3g 4298
Sdha 4003
Cs 3839
Ogdh 3656
Suclg1 3555
Nnt 3360
Sdhb 2165
Fahd1 1729
Sdhc 1198
Me2 -3407
Me3 -4847


NUCLEOBASE BIOSYNTHESIS

NUCLEOBASE BIOSYNTHESIS
655
set NUCLEOBASE BIOSYNTHESIS
setSize 15
pANOVA 0.000668
s.dist 0.507
p.adjustANOVA 0.00803



Top enriched genes

Top 20 genes
GeneID Gene Rank
Umps 7689
Impdh2 7591
Gart 7383
Paics 7071
Adss 6927
Gmps 6784
Atic 6715
Adsl 5423
Adssl1 5346
Impdh1 3125
Ppat 1917
Lhpp 1163
Dhodh 1010
Cad -2095
Pfas -5437

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Umps 7689
Impdh2 7591
Gart 7383
Paics 7071
Adss 6927
Gmps 6784
Atic 6715
Adsl 5423
Adssl1 5346
Impdh1 3125
Ppat 1917
Lhpp 1163
Dhodh 1010
Cad -2095
Pfas -5437


KERATAN SULFATE BIOSYNTHESIS

KERATAN SULFATE BIOSYNTHESIS
505
set KERATAN SULFATE BIOSYNTHESIS
setSize 24
pANOVA 2.54e-05
s.dist 0.497
p.adjustANOVA 0.000636



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prelp 8307
B4galt4 8133
B4gat1 7867
B4galt1 7206
B4galt2 7053
Chst2 6910
B3gnt2 6456
Chst1 5732
St3gal4 5412
Acan 5261
St3gal2 4804
B4galt6 4181
B3gnt4 4171
Fmod 4018
Lum 3386
Slc35d2 3267
B3gnt7 2820
St3gal1 2423
B4galt3 2030
St3gal3 1871

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prelp 8307
B4galt4 8133
B4gat1 7867
B4galt1 7206
B4galt2 7053
Chst2 6910
B3gnt2 6456
Chst1 5732
St3gal4 5412
Acan 5261
St3gal2 4804
B4galt6 4181
B3gnt4 4171
Fmod 4018
Lum 3386
Slc35d2 3267
B3gnt7 2820
St3gal1 2423
B4galt3 2030
St3gal3 1871
B4galt5 1637
Chst5 1487
Ogn -1934
St3gal6 -7863


COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC

COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
182
set COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
setSize 44
pANOVA 1.48e-08
s.dist 0.493
p.adjustANOVA 1.16e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Capza2 7704
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Actr1a 7389
Capza1 7253
Tuba4a 7208
Dctn4 7177
Tuba1a 7067
Rab6a 6581
Rab18 6537
Dctn6 6465
Dctn1 6188
Rab3gap1 6072
Tubb3 5842
Dync1i1 5759
Pla2g6 5480
Dctn5 5433

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Capza2 7704
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Actr1a 7389
Capza1 7253
Tuba4a 7208
Dctn4 7177
Tuba1a 7067
Rab6a 6581
Rab18 6537
Dctn6 6465
Dctn1 6188
Rab3gap1 6072
Tubb3 5842
Dync1i1 5759
Pla2g6 5480
Dctn5 5433
Rab6b 5302
Capzb 5208
Pla2g4a 4647
Tuba1c 4485
Galnt1 4231
Dynll1 3613
Dctn2 3314
Actr10 2962
Pafah1b3 2884
Galnt2 2757
Dync1li1 2623
Pafah1b1 2584
Pafah1b2 2292
Rab3gap2 2191
Agpat3 1986
Tubb6 1806
Dync1h1 1341
Dctn3 329
Bicd2 -362
Dynll2 -1891
Dync1li2 -3541
Dync1i2 -3902
Bicd1 -3999
Tuba8 -5577


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
180
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 2.52e-05
s.dist 0.477
p.adjustANOVA 0.000636



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cct6a 8139
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Cct5 7328
Tuba4a 7208
Cct3 7150
Tuba1a 7067
Tcp1 6639
Cct8 6486
Cct4 6252
Tubb3 5842
Cct7 4843
Pfdn4 4529
Tuba1c 4485
Cct2 3832
Vbp1 3176
Tubb6 1806

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a 8139
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Cct5 7328
Tuba4a 7208
Cct3 7150
Tuba1a 7067
Tcp1 6639
Cct8 6486
Cct4 6252
Tubb3 5842
Cct7 4843
Pfdn4 4529
Tuba1c 4485
Cct2 3832
Vbp1 3176
Tubb6 1806
Pfdn1 574
Pfdn5 -3196
Pfdn6 -3809
Pfdn2 -4915
Tuba8 -5577
Actb -8390


HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR

HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
435
set HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
setSize 48
pANOVA 2.46e-08
s.dist 0.465
p.adjustANOVA 1.7e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspa2 8280
Hspa1b 8162
Tubb2a 8130
Dnaja2 7983
Tuba1b 7873
Capza2 7704
Tubb4b 7622
Dnaja4 7556
Tubb4a 7517
Tubb2b 7504
Actr1a 7389
Dnaja1 7327
Capza1 7253
Tuba4a 7208
Dctn4 7177
Tuba1a 7067
Stip1 6832
Dctn6 6465
Dctn1 6188
Fkbp5 5985

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspa2 8280
Hspa1b 8162
Tubb2a 8130
Dnaja2 7983
Tuba1b 7873
Capza2 7704
Tubb4b 7622
Dnaja4 7556
Tubb4a 7517
Tubb2b 7504
Actr1a 7389
Dnaja1 7327
Capza1 7253
Tuba4a 7208
Dctn4 7177
Tuba1a 7067
Stip1 6832
Dctn6 6465
Dctn1 6188
Fkbp5 5985
Tubb3 5842
Dync1i1 5759
Fkbp4 5611
Dctn5 5433
Capzb 5208
Hspa8 5004
Tuba1c 4485
Dynll1 3613
Ptges3 3550
Dctn2 3314
Actr10 2962
Dync1li1 2623
Nr3c2 2400
Tubb6 1806
Dnajb1 1793
Dync1h1 1341
Dctn3 329
Ar 266
Nr3c1 -1009
Dynll2 -1891
Hsp90ab1 -2348
Hspa1l -2920
Hsp90aa1 -2970
Pgr -3538
Dync1li2 -3541
Dync1i2 -3902
Hspa1a -5092
Tuba8 -5577


KERATAN SULFATE KERATIN METABOLISM

KERATAN SULFATE KERATIN METABOLISM
507
set KERATAN SULFATE KERATIN METABOLISM
setSize 30
pANOVA 1.46e-05
s.dist 0.457
p.adjustANOVA 0.000409



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prelp 8307
B4galt4 8133
B4gat1 7867
B4galt1 7206
B4galt2 7053
Chst2 6910
B3gnt2 6456
Chst1 5732
Hexa 5632
St3gal4 5412
Acan 5261
St3gal2 4804
Gns 4656
Hexb 4301
B4galt6 4181
B3gnt4 4171
Fmod 4018
Lum 3386
Slc35d2 3267
B3gnt7 2820

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prelp 8307
B4galt4 8133
B4gat1 7867
B4galt1 7206
B4galt2 7053
Chst2 6910
B3gnt2 6456
Chst1 5732
Hexa 5632
St3gal4 5412
Acan 5261
St3gal2 4804
Gns 4656
Hexb 4301
B4galt6 4181
B3gnt4 4171
Fmod 4018
Lum 3386
Slc35d2 3267
B3gnt7 2820
St3gal1 2423
Glb1 2200
B4galt3 2030
St3gal3 1871
B4galt5 1637
Chst5 1487
Glb1l 552
Ogn -1934
Galns -4080
St3gal6 -7863


CALNEXIN CALRETICULIN CYCLE

CALNEXIN CALRETICULIN CYCLE
110
set CALNEXIN CALRETICULIN CYCLE
setSize 26
pANOVA 5.9e-05
s.dist 0.455
p.adjustANOVA 0.0012



Top enriched genes

Top 20 genes
GeneID Gene Rank
Calr 8220
Derl2 8209
Pdia3 7888
Prkcsh 7715
Ganab 7291
Rnf185 6706
Os9 6588
Canx 6365
Man1b1 6134
Marchf6 5839
Rnf5 5661
Edem2 5636
Amfr 5428
Rnf139 5303
Uggt1 5299
Syvn1 5168
Ubc 4500
Edem3 2269
Ubb 1303
Rps27a -478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calr 8220
Derl2 8209
Pdia3 7888
Prkcsh 7715
Ganab 7291
Rnf185 6706
Os9 6588
Canx 6365
Man1b1 6134
Marchf6 5839
Rnf5 5661
Edem2 5636
Amfr 5428
Rnf139 5303
Uggt1 5299
Syvn1 5168
Ubc 4500
Edem3 2269
Ubb 1303
Rps27a -478
Rnf103 -721
Edem1 -1059
Sel1l -2256
Uggt2 -2738
Trim13 -3011
Uba52 -8214


GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
391
set GLYCOGEN STORAGE DISEASES
setSize 12
pANOVA 0.00644
s.dist 0.454
p.adjustANOVA 0.0424



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gyg 7709
Gaa 7535
Gbe1 7309
Nhlrc1 6939
G6pc3 6444
Epm2a 5095
Ubc 4500
Ppp1r3c 2878
Gys1 1875
Ubb 1303
Rps27a -478
Uba52 -8214

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gyg 7709
Gaa 7535
Gbe1 7309
Nhlrc1 6939
G6pc3 6444
Epm2a 5095
Ubc 4500
Ppp1r3c 2878
Gys1 1875
Ubb 1303
Rps27a -478
Uba52 -8214


GAP JUNCTION ASSEMBLY

GAP JUNCTION ASSEMBLY
371
set GAP JUNCTION ASSEMBLY
setSize 21
pANOVA 0.000314
s.dist 0.454
p.adjustANOVA 0.00462



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Gjb6 7577
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Gjd2 6953
Gjd3 5958
Tubb3 5842
Gja1 5105
Tuba1c 4485
Gjb1 3853
Gjc1 2485
Tubb6 1806
Gjc2 1414
Gja4 -1332
Tuba8 -5577
Gja5 -7589

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Gjb6 7577
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Gjd2 6953
Gjd3 5958
Tubb3 5842
Gja1 5105
Tuba1c 4485
Gjb1 3853
Gjc1 2485
Tubb6 1806
Gjc2 1414
Gja4 -1332
Tuba8 -5577
Gja5 -7589
Gjb2 -8878


ENDOSOMAL VACUOLAR PATHWAY

ENDOSOMAL VACUOLAR PATHWAY
284
set ENDOSOMAL VACUOLAR PATHWAY
setSize 10
pANOVA 0.0131
s.dist -0.453
p.adjustANOVA 0.0681



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2-T23 -9188
H2-M3 -8824
H2-Q7 -7765
B2m -7131
H2-Q10 -6983
H2-D1 -5043
Lnpep -4287
H2-Q2 -2917
Ctss 2781
Ctsl 5335

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2-T23 -9188
H2-M3 -8824
H2-Q7 -7765
B2m -7131
H2-Q10 -6983
H2-D1 -5043
Lnpep -4287
H2-Q2 -2917
Ctss 2781
Ctsl 5335


RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
842
set RETROGRADE NEUROTROPHIN SIGNALLING
setSize 13
pANOVA 0.00477
s.dist 0.452
p.adjustANOVA 0.0339



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ap2m1 7792
Dnm2 7614
Ap2b1 7522
Dnal4 7381
Ap2a2 6984
Ap2a1 6110
Cltc 4483
Clta 3556
Sh3gl2 2855
Dnm3 2297
Dnm1 814
Ap2s1 -3475
Ntrk1 -7720

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ap2m1 7792
Dnm2 7614
Ap2b1 7522
Dnal4 7381
Ap2a2 6984
Ap2a1 6110
Cltc 4483
Clta 3556
Sh3gl2 2855
Dnm3 2297
Dnm1 814
Ap2s1 -3475
Ntrk1 -7720


GLYCOGEN SYNTHESIS

GLYCOGEN SYNTHESIS
392
set GLYCOGEN SYNTHESIS
setSize 14
pANOVA 0.00363
s.dist 0.449
p.adjustANOVA 0.0274



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pgm1 8318
Ugp2 8093
Gyg 7709
Gbe1 7309
Nhlrc1 6939
Pgm2 6644
Epm2a 5095
Ubc 4500
Ppp1r3c 2878
Gys1 1875
Ubb 1303
Rps27a -478
Pgm2l1 -2578
Uba52 -8214

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pgm1 8318
Ugp2 8093
Gyg 7709
Gbe1 7309
Nhlrc1 6939
Pgm2 6644
Epm2a 5095
Ubc 4500
Ppp1r3c 2878
Gys1 1875
Ubb 1303
Rps27a -478
Pgm2l1 -2578
Uba52 -8214


SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
909
set SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
setSize 23
pANOVA 0.000265
s.dist 0.439
p.adjustANOVA 0.004



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Vps4a 7252
Tuba4a 7208
Chmp7 7151
Chmp3 7107
Tuba1a 7067
Chmp2b 6346
Chmp4b 6041
Spast 5925
Tubb3 5842
Tuba1c 4485
Tubb6 1806
Chmp6 1720
Lemd2 -1060
Chmp2a -2646
Ist1 -4378

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Vps4a 7252
Tuba4a 7208
Chmp7 7151
Chmp3 7107
Tuba1a 7067
Chmp2b 6346
Chmp4b 6041
Spast 5925
Tubb3 5842
Tuba1c 4485
Tubb6 1806
Chmp6 1720
Lemd2 -1060
Chmp2a -2646
Ist1 -4378
Cc2d1b -5268
Tuba8 -5577
Chmp4c -8521


LDL CLEARANCE

LDL CLEARANCE
516
set LDL CLEARANCE
setSize 16
pANOVA 0.00246
s.dist 0.437
p.adjustANOVA 0.021



Top enriched genes

Top 20 genes
GeneID Gene Rank
Lipa 8232
Ap2m1 7792
Ap2b1 7522
Npc1 7221
Ap2a2 6984
Soat1 6714
Ap2a1 6110
Nceh1 5557
Cltc 4483
Clta 3556
Ldlr 1991
Npc2 1627
Lsr 745
Ap2s1 -3475
Pcsk9 -4163
Ldlrap1 -6117

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lipa 8232
Ap2m1 7792
Ap2b1 7522
Npc1 7221
Ap2a2 6984
Soat1 6714
Ap2a1 6110
Nceh1 5557
Cltc 4483
Clta 3556
Ldlr 1991
Npc2 1627
Lsr 745
Ap2s1 -3475
Pcsk9 -4163
Ldlrap1 -6117


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
146
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 10
pANOVA 0.0169
s.dist 0.436
p.adjustANOVA 0.08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sfn 6246
Chek1 6044
Ywhaq 5968
Ywhab 4891
Ywhah 3722
Wee1 3716
Ywhae 2826
Ywhaz 1182
Ywhag 961
Chek2 -1400

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sfn 6246
Chek1 6044
Ywhaq 5968
Ywhab 4891
Ywhah 3722
Wee1 3716
Ywhae 2826
Ywhaz 1182
Ywhag 961
Chek2 -1400


OLFACTORY SIGNALING PATHWAY

OLFACTORY SIGNALING PATHWAY
664
set OLFACTORY SIGNALING PATHWAY
setSize 40
pANOVA 2.56e-06
s.dist -0.43
p.adjustANOVA 0.000112



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rtp4 -9185
Olfr981 -9130
Olfr354 -9066
Olfr635 -8967
Olfr1310 -8891
Olfr1192-ps1 -8827
Olfr796 -8547
Olfr1564 -8513
Olfr2 -8472
Olfr735 -8412
Olfr63 -8335
Olfr1309 -8324
Olfr986 -8079
Olfr287 -7681
Olfr90 -7344
Olfr78 -7306
Olfr31 -6758
Olfr804 -6712
Gng13 -6622
Olfr1385 -6534

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rtp4 -9185
Olfr981 -9130
Olfr354 -9066
Olfr635 -8967
Olfr1310 -8891
Olfr1192-ps1 -8827
Olfr796 -8547
Olfr1564 -8513
Olfr2 -8472
Olfr735 -8412
Olfr63 -8335
Olfr1309 -8324
Olfr986 -8079
Olfr287 -7681
Olfr90 -7344
Olfr78 -7306
Olfr31 -6758
Olfr804 -6712
Gng13 -6622
Olfr1385 -6534
Olfr161 -5851
Olfr365 -5455
Olfr137 -5449
Olfr713 -5014
Reep4 -4431
Olfr648 -4383
Olfr147 -3210
Olfr558 -2465
Olfr1507 -587
Reep6 -581
Reep3 -347
Olfr446 176
Olfr95 313
Olfr552 353
Reep1 2405
Gnal 4239
Reep2 5124
Olfr464 6000
Gnb1 6352
Reep5 6884


RHO GTPASES ACTIVATE IQGAPS

RHO GTPASES ACTIVATE IQGAPS
848
set RHO GTPASES ACTIVATE IQGAPS
setSize 23
pANOVA 0.000381
s.dist 0.428
p.adjustANOVA 0.00521



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Ctnna1 7489
Tuba4a 7208
Tuba1a 7067
Ctnnb1 6810
Men1 6234
Rac1 6022
Tubb3 5842
Tuba1c 4485
Cdc42 3640
Iqgap2 2145
Actg1 1983
Tubb6 1806
Calm1 451
Iqgap1 -602
Cdh1 -3096

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Ctnna1 7489
Tuba4a 7208
Tuba1a 7067
Ctnnb1 6810
Men1 6234
Rac1 6022
Tubb3 5842
Tuba1c 4485
Cdc42 3640
Iqgap2 2145
Actg1 1983
Tubb6 1806
Calm1 451
Iqgap1 -602
Cdh1 -3096
Clip1 -5312
Tuba8 -5577
Actb -8390


RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY
777
set RECEPTOR MEDIATED MITOPHAGY
setSize 11
pANOVA 0.0149
s.dist 0.424
p.adjustANOVA 0.0749



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fundc1 6709
Atg12 6464
Csnk2a2 5876
Csnk2b 5064
Ulk1 4360
Map1lc3b 3536
Src 2551
Pgam5 2243
Atg5 1480
Map1lc3a 861
Csnk2a1 -2742

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fundc1 6709
Atg12 6464
Csnk2a2 5876
Csnk2b 5064
Ulk1 4360
Map1lc3b 3536
Src 2551
Pgam5 2243
Atg5 1480
Map1lc3a 861
Csnk2a1 -2742


PURINE SALVAGE

PURINE SALVAGE
758
set PURINE SALVAGE
setSize 12
pANOVA 0.0114
s.dist 0.422
p.adjustANOVA 0.0622



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adk 6834
Pnp2 6409
Gmpr2 6404
Dck 6351
Dguok 5001
Hprt 4960
Gmpr 3868
Adal 3166
Ampd3 2029
Ampd2 746
Ada -2926
Aprt -3368

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adk 6834
Pnp2 6409
Gmpr2 6404
Dck 6351
Dguok 5001
Hprt 4960
Gmpr 3868
Adal 3166
Ampd3 2029
Ampd2 746
Ada -2926
Aprt -3368


N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
595
set N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
setSize 35
pANOVA 1.74e-05
s.dist 0.42
p.adjustANOVA 0.000475



Top enriched genes

Top 20 genes
GeneID Gene Rank
Calr 8220
Derl2 8209
Pdia3 7888
Ngly1 7717
Prkcsh 7715
Mlec 7562
Vcp 7408
Ganab 7291
Rnf185 6706
Os9 6588
Derl1 6478
Canx 6365
Man1b1 6134
Marchf6 5839
Rnf5 5661
Edem2 5636
Amfr 5428
Rnf139 5303
Uggt1 5299
Syvn1 5168

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Calr 8220
Derl2 8209
Pdia3 7888
Ngly1 7717
Prkcsh 7715
Mlec 7562
Vcp 7408
Ganab 7291
Rnf185 6706
Os9 6588
Derl1 6478
Canx 6365
Man1b1 6134
Marchf6 5839
Rnf5 5661
Edem2 5636
Amfr 5428
Rnf139 5303
Uggt1 5299
Syvn1 5168
Ubc 4500
Rad23b 3835
Edem3 2269
Ubb 1303
Psmc1 753
Rps27a -478
Rnf103 -721
Edem1 -1059
Ubxn1 -2035
Sel1l -2256
Uggt2 -2738
Trim13 -3011
Mogs -3451
Engase -7024
Uba52 -8214


CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
125
set CD28 DEPENDENT VAV1 PATHWAY
setSize 11
pANOVA 0.0164
s.dist 0.418
p.adjustANOVA 0.0789



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cd86 6435
Pak1 6372
Rac1 6022
Pak2 5893
Fyn 4408
Cdc42 3640
Pak3 3584
Lck 3286
Vav1 1300
Grb2 -450
Cd80 -4688

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cd86 6435
Pak1 6372
Rac1 6022
Pak2 5893
Fyn 4408
Cdc42 3640
Pak3 3584
Lck 3286
Vav1 1300
Grb2 -450
Cd80 -4688


ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING

ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING
43
set ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING
setSize 11
pANOVA 0.0165
s.dist 0.417
p.adjustANOVA 0.0789



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prkcsh 7715
Capza2 7704
Mapk3 7701
Capza1 7253
Mapk1 7097
Ddost 5927
App 5597
Hmgb1 -1491
Ager -2689
Lgals3 -3826
S100b -5232

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prkcsh 7715
Capza2 7704
Mapk3 7701
Capza1 7253
Mapk1 7097
Ddost 5927
App 5597
Hmgb1 -1491
Ager -2689
Lgals3 -3826
S100b -5232


N GLYCAN ANTENNAE ELONGATION

N GLYCAN ANTENNAE ELONGATION
593
set N GLYCAN ANTENNAE ELONGATION
setSize 15
pANOVA 0.00519
s.dist 0.417
p.adjustANOVA 0.0356



Top enriched genes

Top 20 genes
GeneID Gene Rank
B4galt4 8133
B4galt1 7206
B4galt2 7053
St8sia3 5894
St3gal4 5412
B4galt6 4181
St8sia2 3411
Mgat4b 3296
B4galt3 2030
B4galt5 1637
St8sia6 1391
Mgat4c 919
Mgat4a 5
St6gal1 -307
Mgat5 -1593

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B4galt4 8133
B4galt1 7206
B4galt2 7053
St8sia3 5894
St3gal4 5412
B4galt6 4181
St8sia2 3411
Mgat4b 3296
B4galt3 2030
B4galt5 1637
St8sia6 1391
Mgat4c 919
Mgat4a 5
St6gal1 -307
Mgat5 -1593


TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX

TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
1129
set TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
setSize 12
pANOVA 0.0124
s.dist 0.417
p.adjustANOVA 0.0654



Top enriched genes

Top 20 genes
GeneID Gene Rank
Chmp7 7151
Chmp3 7107
Chmp2b 6346
Becn1 6136
Chmp4b 6041
Uvrag 5912
Pik3c3 3997
Map1lc3b 3536
Pik3r4 2154
Chmp6 1720
Chmp2a -2646
Chmp4c -8521

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Chmp7 7151
Chmp3 7107
Chmp2b 6346
Becn1 6136
Chmp4b 6041
Uvrag 5912
Pik3c3 3997
Map1lc3b 3536
Pik3r4 2154
Chmp6 1720
Chmp2a -2646
Chmp4c -8521


WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
1173
set WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
setSize 13
pANOVA 0.00963
s.dist 0.415
p.adjustANOVA 0.0544



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fzd2 8203
Ap2m1 7792
Ap2b1 7522
Ap2a2 6984
Fzd5 6688
Ap2a1 6110
Cltc 4483
Clta 3556
Ror2 3167
Cltb 3123
Ap2s1 -3475
Wnt5a -5644
Ror1 -6564

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fzd2 8203
Ap2m1 7792
Ap2b1 7522
Ap2a2 6984
Fzd5 6688
Ap2a1 6110
Cltc 4483
Clta 3556
Ror2 3167
Cltb 3123
Ap2s1 -3475
Wnt5a -5644
Ror1 -6564


SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
1049
set SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
setSize 10
pANOVA 0.0235
s.dist 0.414
p.adjustANOVA 0.1



Top enriched genes

Top 20 genes
GeneID Gene Rank
Itpk1 7922
Nudt11 7798
Ip6k3 7087
Nudt10 5333
Nudt4 3963
Ip6k1 2822
Nudt3 2741
Ippk 610
Ppip5k1 -2554
Ppip5k2 -3534

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itpk1 7922
Nudt11 7798
Ip6k3 7087
Nudt10 5333
Nudt4 3963
Ip6k1 2822
Nudt3 2741
Ippk 610
Ppip5k1 -2554
Ppip5k2 -3534


GLYCOGEN METABOLISM

GLYCOGEN METABOLISM
390
set GLYCOGEN METABOLISM
setSize 25
pANOVA 0.000353
s.dist 0.413
p.adjustANOVA 0.00501



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pgm1 8318
Ugp2 8093
Gyg 7709
Gaa 7535
Pygb 7372
Gbe1 7309
Nhlrc1 6939
Pygm 6866
Pgm2 6644
Phkb 5292
Epm2a 5095
Ubc 4500
Phka1 3669
Ppp1r3c 2878
Gys1 1875
Phkg1 1377
Phkg2 1354
Ubb 1303
Agl 1034
Calm1 451

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pgm1 8318
Ugp2 8093
Gyg 7709
Gaa 7535
Pygb 7372
Gbe1 7309
Nhlrc1 6939
Pygm 6866
Pgm2 6644
Phkb 5292
Epm2a 5095
Ubc 4500
Phka1 3669
Ppp1r3c 2878
Gys1 1875
Phkg1 1377
Phkg2 1354
Ubb 1303
Agl 1034
Calm1 451
Rps27a -478
Phka2 -1545
Pgm2l1 -2578
Pygl -2603
Uba52 -8214


REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
824
set REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
setSize 14
pANOVA 0.00818
s.dist 0.408
p.adjustANOVA 0.0492



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pou4f1 7924
Banp 7905
Trp73 7773
Ppp1r13b 7716
Pou4f2 5931
Ppp1r13l 4079
Trp53 3770
Akt1 2876
Zfp385a 2516
Phf20 1127
Akt3 -553
Akt2 -867
Trp53bp2 -1465
Trp63 -4363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pou4f1 7924
Banp 7905
Trp73 7773
Ppp1r13b 7716
Pou4f2 5931
Ppp1r13l 4079
Trp53 3770
Akt1 2876
Zfp385a 2516
Phf20 1127
Akt3 -553
Akt2 -867
Trp53bp2 -1465
Trp63 -4363


CYTOSOLIC TRNA AMINOACYLATION

CYTOSOLIC TRNA AMINOACYLATION
204
set CYTOSOLIC TRNA AMINOACYLATION
setSize 24
pANOVA 0.000542
s.dist 0.408
p.adjustANOVA 0.00694



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hars 8296
Rars 7470
Aimp2 7422
Farsb 7200
Ppa1 7100
Eef1e1 6693
Yars 6613
Mars1 6307
Wars 6255
Aars 5085
Iars 5037
Qars 4241
Gars 3840
Dars 3101
Kars 2794
Nars 1886
Lars 954
Aimp1 -438
Tars -1336
Cars -1854

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hars 8296
Rars 7470
Aimp2 7422
Farsb 7200
Ppa1 7100
Eef1e1 6693
Yars 6613
Mars1 6307
Wars 6255
Aars 5085
Iars 5037
Qars 4241
Gars 3840
Dars 3101
Kars 2794
Nars 1886
Lars 954
Aimp1 -438
Tars -1336
Cars -1854
Sars -2074
Eprs -2545
Vars -2868
Farsa -3226


INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE

INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
455
set INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
setSize 22
pANOVA 0.000958
s.dist 0.407
p.adjustANOVA 0.0105



Top enriched genes

Top 20 genes
GeneID Gene Rank
Get1 8075
Stx1a 7268
Prnp 7171
Get3 7133
Bag6 5899
App 5597
Ubl4a 5381
Sgta 5139
Cyb5a 5083
Vamp2 4705
Emd 4453
Serp1 4344
Vapa 3068
Sec61g 2203
Hmox1 1080
Stx5a 589
Caml 501
Otof -913
Get4 -945
Sec61b -1209

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Get1 8075
Stx1a 7268
Prnp 7171
Get3 7133
Bag6 5899
App 5597
Ubl4a 5381
Sgta 5139
Cyb5a 5083
Vamp2 4705
Emd 4453
Serp1 4344
Vapa 3068
Sec61g 2203
Hmox1 1080
Stx5a 589
Caml 501
Otof -913
Get4 -945
Sec61b -1209
Aldh3a2 -2412
Ube2j2 -2804


GLYCOSPHINGOLIPID METABOLISM

GLYCOSPHINGOLIPID METABOLISM
395
set GLYCOSPHINGOLIPID METABOLISM
setSize 38
pANOVA 1.44e-05
s.dist 0.407
p.adjustANOVA 0.000409



Top enriched genes

Top 20 genes
GeneID Gene Rank
B3galnt1 8049
B4galnt1 7752
Ugt8a 7448
Galc 7210
Neu2 7012
Smpd1 6878
Gba2 6789
Arsa 6740
Arsb 6727
Neu1 6712
Asah1 6628
Esyt1 6584
Gltp 6313
Gm2a 6086
Neu4 5752
Psap 5640
Hexa 5632
Gba 5555
Gla 4912
Hexb 4301

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3galnt1 8049
B4galnt1 7752
Ugt8a 7448
Galc 7210
Neu2 7012
Smpd1 6878
Gba2 6789
Arsa 6740
Arsb 6727
Neu1 6712
Asah1 6628
Esyt1 6584
Gltp 6313
Gm2a 6086
Neu4 5752
Psap 5640
Hexa 5632
Gba 5555
Gla 4912
Hexb 4301
Smpd3 4201
Ugcg 2966
Neu3 2480
Sumf1 2210
Glb1 2200
Sumf2 2175
Arsk 1769
Glb1l 552
Esyt3 -116
Cptp -917
Smpd4 -2131
Ctsa -2132
Arsj -2309
Asah2 -2426
Smpd2 -2819
Arsg -3310
Cerk -4543
Esyt2 -6870


WNT LIGAND BIOGENESIS AND TRAFFICKING

WNT LIGAND BIOGENESIS AND TRAFFICKING
1172
set WNT LIGAND BIOGENESIS AND TRAFFICKING
setSize 21
pANOVA 0.00161
s.dist 0.398
p.adjustANOVA 0.0157



Top enriched genes

Top 20 genes
GeneID Gene Rank
Wnt11 8332
Wls 8074
Wnt9b 7248
Snx3 7021
Vps35 6713
Vps26a 4676
Wnt7b 4599
Vps29 4572
Wnt9a 3777
Wnt3 3484
Wnt10a 2478
Wnt2b 2458
Wnt2 2439
Wnt7a 2245
Wnt4 1511
Wnt16 1064
Porcn 771
Tmed5 170
Wnt5b 161
Wnt6 -1598

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Wnt11 8332
Wls 8074
Wnt9b 7248
Snx3 7021
Vps35 6713
Vps26a 4676
Wnt7b 4599
Vps29 4572
Wnt9a 3777
Wnt3 3484
Wnt10a 2478
Wnt2b 2458
Wnt2 2439
Wnt7a 2245
Wnt4 1511
Wnt16 1064
Porcn 771
Tmed5 170
Wnt5b 161
Wnt6 -1598
Wnt5a -5644


SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
1051
set SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize 20
pANOVA 0.00211
s.dist 0.397
p.adjustANOVA 0.0191



Top enriched genes

Top 20 genes
GeneID Gene Rank
Acsl4 7747
Acsbg1 7636
Hsd17b12 7631
Elovl1 7473
Tecr 7018
Hacd2 6515
Acsl6 6049
Hacd3 5881
Elovl4 5850
Acsl5 4917
Acsl3 4277
Elovl6 2861
Acsl1 2715
Elovl5 2632
Elovl2 2613
Slc27a3 2119
Acsf3 -1821
Hacd4 -3874
Elovl7 -8098
Hacd1 -8737

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acsl4 7747
Acsbg1 7636
Hsd17b12 7631
Elovl1 7473
Tecr 7018
Hacd2 6515
Acsl6 6049
Hacd3 5881
Elovl4 5850
Acsl5 4917
Acsl3 4277
Elovl6 2861
Acsl1 2715
Elovl5 2632
Elovl2 2613
Slc27a3 2119
Acsf3 -1821
Hacd4 -3874
Elovl7 -8098
Hacd1 -8737


GLYCOGEN BREAKDOWN GLYCOGENOLYSIS

GLYCOGEN BREAKDOWN GLYCOGENOLYSIS
389
set GLYCOGEN BREAKDOWN GLYCOGENOLYSIS
setSize 14
pANOVA 0.0108
s.dist 0.394
p.adjustANOVA 0.0596



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gyg 7709
Gaa 7535
Pygb 7372
Pygm 6866
Pgm2 6644
Phkb 5292
Phka1 3669
Phkg1 1377
Phkg2 1354
Agl 1034
Calm1 451
Phka2 -1545
Pgm2l1 -2578
Pygl -2603

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gyg 7709
Gaa 7535
Pygb 7372
Pygm 6866
Pgm2 6644
Phkb 5292
Phka1 3669
Phkg1 1377
Phkg2 1354
Agl 1034
Calm1 451
Phka2 -1545
Pgm2l1 -2578
Pygl -2603


SUPPRESSION OF PHAGOSOMAL MATURATION

SUPPRESSION OF PHAGOSOMAL MATURATION
1029
set SUPPRESSION OF PHAGOSOMAL MATURATION
setSize 12
pANOVA 0.0183
s.dist 0.393
p.adjustANOVA 0.0839



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rab5a 7203
Atp6v1h 6959
Rab7 5493
Hgs 5340
Kpna1 5148
Ubc 4500
Coro1a 3187
Kpnb1 3095
Vps33b 2935
Ubb 1303
Rps27a -478
Uba52 -8214

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rab5a 7203
Atp6v1h 6959
Rab7 5493
Hgs 5340
Kpna1 5148
Ubc 4500
Coro1a 3187
Kpnb1 3095
Vps33b 2935
Ubb 1303
Rps27a -478
Uba52 -8214


CS DS DEGRADATION

CS DS DEGRADATION
192
set CS DS DEGRADATION
setSize 14
pANOVA 0.0124
s.dist 0.386
p.adjustANOVA 0.0653



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ids 7281
Arsb 6727
Vcan 6689
Bgn 6560
Hexa 5632
Cspg4 4947
Bcan 4794
Cspg5 4632
Hexb 4301
Hyal3 1783
Hyal1 -217
Dcn -2326
Ncan -3335
Idua -5808

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ids 7281
Arsb 6727
Vcan 6689
Bgn 6560
Hexa 5632
Cspg4 4947
Bcan 4794
Cspg5 4632
Hexb 4301
Hyal3 1783
Hyal1 -217
Dcn -2326
Ncan -3335
Idua -5808


IRE1ALPHA ACTIVATES CHAPERONES

IRE1ALPHA ACTIVATES CHAPERONES
499
set IRE1ALPHA ACTIVATES CHAPERONES
setSize 50
pANOVA 2.69e-06
s.dist 0.384
p.adjustANOVA 0.000113



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tpp1 8361
Pdia6 8350
Dnajc3 8341
Hspa5 8305
Xbp1 8257
Srprb 7690
Atp6v0d1 7589
Dnajb11 7552
Gfpt1 7055
Dnajb9 7051
Srpr 6286
Lmna 6276
Dctn1 6188
Preb 6171
Hyou1 6156
Kdelr3 6076
Ppp2r5b 5757
Yif1a 5615
Ssr1 5263
Cxxc1 5183

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tpp1 8361
Pdia6 8350
Dnajc3 8341
Hspa5 8305
Xbp1 8257
Srprb 7690
Atp6v0d1 7589
Dnajb11 7552
Gfpt1 7055
Dnajb9 7051
Srpr 6286
Lmna 6276
Dctn1 6188
Preb 6171
Hyou1 6156
Kdelr3 6076
Ppp2r5b 5757
Yif1a 5615
Ssr1 5263
Cxxc1 5183
Syvn1 5168
Gosr2 4982
Add1 4819
Gsk3a 4754
Serp1 4344
Fkbp14 3752
Klhdc3 3596
Sec31a 2662
Hdgf 2607
Extl2 1797
Zbtb17 1437
Shc1 1324
Tln1 568
Pla2g4b 350
Extl3 129
Ddx11 -7
Tspyl2 -19
Cul7 -176
Mydgf -424
Sult1a1 -440
Ctdsp2 -499
Arfgap1 -632
Edem1 -1059
Ern1 -1073
Tatdn2 -2662
Wfs1 -2872
Extl1 -3822
Acadvl -5474
Wipi1 -6579
Pdia5 -6746


KERATAN SULFATE DEGRADATION

KERATAN SULFATE DEGRADATION
506
set KERATAN SULFATE DEGRADATION
setSize 11
pANOVA 0.0284
s.dist 0.382
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prelp 8307
Hexa 5632
Acan 5261
Gns 4656
Hexb 4301
Fmod 4018
Lum 3386
Glb1 2200
Glb1l 552
Ogn -1934
Galns -4080

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prelp 8307
Hexa 5632
Acan 5261
Gns 4656
Hexb 4301
Fmod 4018
Lum 3386
Glb1 2200
Glb1l 552
Ogn -1934
Galns -4080


ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
15
set ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
setSize 20
pANOVA 0.00336
s.dist 0.379
p.adjustANOVA 0.0262



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Prkab1 6043
Tubb3 5842
Prkag2 5796
Tuba1c 4485
Tubb6 1806
Prkag1 1594
Prkaa1 1545
Prkaa2 1347
Calm1 451
Mapt -5193
Tuba8 -5577
Prkab2 -5817
Camkk2 -7039

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Prkab1 6043
Tubb3 5842
Prkag2 5796
Tuba1c 4485
Tubb6 1806
Prkag1 1594
Prkaa1 1545
Prkaa2 1347
Calm1 451
Mapt -5193
Tuba8 -5577
Prkab2 -5817
Camkk2 -7039


RECYCLING PATHWAY OF L1

RECYCLING PATHWAY OF L1
783
set RECYCLING PATHWAY OF L1
setSize 40
pANOVA 3.41e-05
s.dist 0.379
p.adjustANOVA 0.00082



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rps6ka6 8267
Tubb2a 8130
Tuba1b 7873
Ap2m1 7792
Tubb4b 7622
Dnm2 7614
Ap2b1 7522
Tubb4a 7517
Tubb2b 7504
Rps6ka4 7347
Tuba4a 7208
Mapk1 7097
Tuba1a 7067
Ap2a2 6984
Ezr 6776
Ap2a1 6110
Tubb3 5842
Tuba1c 4485
Cltc 4483
Clta 3556

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rps6ka6 8267
Tubb2a 8130
Tuba1b 7873
Ap2m1 7792
Tubb4b 7622
Dnm2 7614
Ap2b1 7522
Tubb4a 7517
Tubb2b 7504
Rps6ka4 7347
Tuba4a 7208
Mapk1 7097
Tuba1a 7067
Ap2a2 6984
Ezr 6776
Ap2a1 6110
Tubb3 5842
Tuba1c 4485
Cltc 4483
Clta 3556
L1cam 3330
Sh3gl2 2855
Src 2551
Dnm3 2297
Rps6ka5 2127
Actg1 1983
Tubb6 1806
Numb 1403
Dnm1 814
Msn 773
Shtn1 78
Rps6ka2 -976
Rps6ka3 -1313
Rdx -1895
Ap2s1 -3475
Rps6ka1 -4789
Tuba8 -5577
Dpysl2 -5750
Actb -8390
Kif4 -8456


POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
725
set POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize 17
pANOVA 0.00701
s.dist 0.378
p.adjustANOVA 0.0449



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Tbcd 7046
Tubb3 5842
Tuba1c 4485
Tubb6 1806
Arl2 -1610
Tbcb -1675
Tbcc -2972
Tbca -5113
Tuba8 -5577
Tbce -5838

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tubb2a 8130
Tuba1b 7873
Tubb4b 7622
Tubb4a 7517
Tubb2b 7504
Tuba4a 7208
Tuba1a 7067
Tbcd 7046
Tubb3 5842
Tuba1c 4485
Tubb6 1806
Arl2 -1610
Tbcb -1675
Tbcc -2972
Tbca -5113
Tuba8 -5577
Tbce -5838


COPI MEDIATED ANTEROGRADE TRANSPORT

COPI MEDIATED ANTEROGRADE TRANSPORT
183
set COPI MEDIATED ANTEROGRADE TRANSPORT
setSize 91
pANOVA 5.78e-10
s.dist 0.376
p.adjustANOVA 5.23e-08



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tmed9 8187
Tubb2a 8130
Arf4 8012
Tmed2 7972
Tuba1b 7873
Cog4 7856
Capza2 7704
Tmed7 7627
Tubb4b 7622
Cog1 7546
Tubb4a 7517
Tubb2b 7504
Copb1 7477
Actr1a 7389
Capza1 7253
Tuba4a 7208
Dctn4 7177
Tuba1a 7067
Cog6 6960
Arf1 6877

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tmed9 8187
Tubb2a 8130
Arf4 8012
Tmed2 7972
Tuba1b 7873
Cog4 7856
Capza2 7704
Tmed7 7627
Tubb4b 7622
Cog1 7546
Tubb4a 7517
Tubb2b 7504
Copb1 7477
Actr1a 7389
Capza1 7253
Tuba4a 7208
Dctn4 7177
Tuba1a 7067
Cog6 6960
Arf1 6877
Kdelr1 6862
Uso1 6853
Dctn6 6465
Arcn1 6445
Cd55 6367
Rab1b 6316
Dctn1 6188
Rab1a 6145
Kdelr3 6076
Tmed10 6028
Napg 5982
Tubb3 5842
Dync1i1 5759
Arfgap3 5741
Napa 5703
Folr1 5697
Dctn5 5433
Arfgap2 5268
Capzb 5208
Gosr2 4982
Nsf 4518
Tmed3 4493
Tuba1c 4485
Tmem115 4275
Ykt6 4251
Copa 4198
Gorasp1 4112
Copb2 3644
Dynll1 3613
Copz1 3591
Gbf1 3363
Dctn2 3314
Cope 3293
Cog5 3262
Copg1 3114
Actr10 2962
Dync1li1 2623
Napb 2381
Tubb6 1806
Arf3 1385
Dync1h1 1341
Sptbn5 1069
Cog2 852
Copg2 838
Sptan1 630
Stx5a 589
Dctn3 329
Cog7 83
Bet1 -245
Gosr1 -355
Arfgap1 -632
Sptbn1 -845
Arf5 -1490
Cog8 -1844
Dynll2 -1891
Cog3 -2028
Sptbn2 -2336
Sptb -2663
Golga2 -3175
Sptbn4 -3397
Copz2 -3435
Dync1li2 -3541
Dync1i2 -3902
Ank1 -5320
Cd59b -5413
Tuba8 -5577
Kdelr2 -5779
Ank2 -6065
Bet1l -7424
Golgb1 -7435
Ank3 -8754


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report