date generated: 2023-08-29

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
x
0610009B22Rik 0.4565576
0610009E02Rik -0.4069908
0610009L18Rik -0.1869110
0610010K14Rik -0.3711485
0610012G03Rik -0.3421633
0610030E20Rik 0.0842539

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17643
duplicated_genes_present 0
num_profile_genes_in_sets 8424
num_profile_genes_not_in_sets 9219

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 426
num_genesets_included 1178

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pANOVA s.dist p.adjustANOVA
CITRIC ACID CYCLE TCA CYCLE 22 3.44e-05 0.510 9.41e-04
OLFACTORY SIGNALING PATHWAY 37 1.51e-07 -0.499 1.11e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 4.20e-03 0.498 3.30e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.04e-03 0.494 2.58e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.62e-03 0.485 2.96e-02
CALNEXIN CALRETICULIN CYCLE 26 2.35e-05 0.479 7.68e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.58e-04 0.476 2.98e-03
RHOBTB3 ATPASE CYCLE 10 9.36e-03 0.475 5.82e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 1.92e-04 0.470 3.37e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.14e-03 0.470 1.27e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.98e-03 0.461 3.17e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 1.25e-02 0.456 7.13e-02
MET ACTIVATES RAP1 AND RAC1 10 1.33e-02 0.452 7.32e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.75e-04 0.452 3.21e-03
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.82e-03 0.435 3.64e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.87e-02 0.429 8.96e-02
SCAVENGING OF HEME FROM PLASMA 11 1.44e-02 -0.426 7.61e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.82e-04 0.426 1.14e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.56e-05 0.422 5.81e-04
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 1.88e-04 0.415 3.35e-03
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.13e-04 0.408 4.60e-03
CARNITINE METABOLISM 14 8.34e-03 0.407 5.35e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 2.60e-02 0.407 1.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 2.60e-02 0.407 1.11e-01
PROLONGED ERK ACTIVATION EVENTS 14 9.38e-03 0.401 5.82e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.62e-03 0.398 5.04e-02
FERTILIZATION 13 1.30e-02 -0.398 7.27e-02
GLYCOSPHINGOLIPID METABOLISM 38 2.63e-05 0.394 7.96e-04
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 3.83e-03 0.394 3.07e-02
SPHINGOLIPID METABOLISM 80 1.27e-09 0.393 1.87e-07
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 2.42e-02 -0.392 1.07e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 1.25e-05 0.390 5.22e-04
NUCLEOBASE BIOSYNTHESIS 15 1.00e-02 0.384 6.10e-02
COHESIN LOADING ONTO CHROMATIN 10 3.74e-02 0.380 1.43e-01
CTLA4 INHIBITORY SIGNALING 20 3.62e-03 0.376 2.96e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 1.98e-02 0.373 9.44e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.24e-02 0.373 7.10e-02
RHOV GTPASE CYCLE 33 2.41e-04 0.369 3.89e-03
PLATELET SENSITIZATION BY LDL 15 1.38e-02 0.367 7.45e-02
INSULIN PROCESSING 24 1.96e-03 0.365 1.88e-02
LDL CLEARANCE 16 1.15e-02 0.365 6.71e-02
FATTY ACYL COA BIOSYNTHESIS 32 4.06e-04 0.361 5.69e-03
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 4.93e-02 0.359 1.73e-01
RECEPTOR MEDIATED MITOPHAGY 11 4.06e-02 0.357 1.52e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.70e-02 0.356 8.53e-02
INTRA GOLGI TRAFFIC 43 6.28e-05 0.353 1.45e-03
RHOF GTPASE CYCLE 41 9.74e-05 0.352 2.05e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 2.38e-02 0.349 1.07e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 3.01e-02 0.347 1.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.94e-05 0.345 8.65e-04


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
CITRIC ACID CYCLE TCA CYCLE 22 3.44e-05 0.510000 9.41e-04
OLFACTORY SIGNALING PATHWAY 37 1.51e-07 -0.499000 1.11e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 4.20e-03 0.498000 3.30e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.04e-03 0.494000 2.58e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 3.62e-03 0.485000 2.96e-02
CALNEXIN CALRETICULIN CYCLE 26 2.35e-05 0.479000 7.68e-04
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.58e-04 0.476000 2.98e-03
RHOBTB3 ATPASE CYCLE 10 9.36e-03 0.475000 5.82e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 1.92e-04 0.470000 3.37e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.14e-03 0.470000 1.27e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.98e-03 0.461000 3.17e-02
ASPARTATE AND ASPARAGINE METABOLISM 10 1.25e-02 0.456000 7.13e-02
MET ACTIVATES RAP1 AND RAC1 10 1.33e-02 0.452000 7.32e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.75e-04 0.452000 3.21e-03
RETROGRADE NEUROTROPHIN SIGNALLING 14 4.82e-03 0.435000 3.64e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.87e-02 0.429000 8.96e-02
SCAVENGING OF HEME FROM PLASMA 11 1.44e-02 -0.426000 7.61e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 9.82e-04 0.426000 1.14e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.56e-05 0.422000 5.81e-04
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 1.88e-04 0.415000 3.35e-03
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 3.13e-04 0.408000 4.60e-03
CARNITINE METABOLISM 14 8.34e-03 0.407000 5.35e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 2.60e-02 0.407000 1.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 2.60e-02 0.407000 1.11e-01
PROLONGED ERK ACTIVATION EVENTS 14 9.38e-03 0.401000 5.82e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.62e-03 0.398000 5.04e-02
FERTILIZATION 13 1.30e-02 -0.398000 7.27e-02
GLYCOSPHINGOLIPID METABOLISM 38 2.63e-05 0.394000 7.96e-04
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 3.83e-03 0.394000 3.07e-02
SPHINGOLIPID METABOLISM 80 1.27e-09 0.393000 1.87e-07
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS 11 2.42e-02 -0.392000 1.07e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 1.25e-05 0.390000 5.22e-04
NUCLEOBASE BIOSYNTHESIS 15 1.00e-02 0.384000 6.10e-02
COHESIN LOADING ONTO CHROMATIN 10 3.74e-02 0.380000 1.43e-01
CTLA4 INHIBITORY SIGNALING 20 3.62e-03 0.376000 2.96e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 1.98e-02 0.373000 9.44e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.24e-02 0.373000 7.10e-02
RHOV GTPASE CYCLE 33 2.41e-04 0.369000 3.89e-03
PLATELET SENSITIZATION BY LDL 15 1.38e-02 0.367000 7.45e-02
INSULIN PROCESSING 24 1.96e-03 0.365000 1.88e-02
LDL CLEARANCE 16 1.15e-02 0.365000 6.71e-02
FATTY ACYL COA BIOSYNTHESIS 32 4.06e-04 0.361000 5.69e-03
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 4.93e-02 0.359000 1.73e-01
RECEPTOR MEDIATED MITOPHAGY 11 4.06e-02 0.357000 1.52e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.70e-02 0.356000 8.53e-02
INTRA GOLGI TRAFFIC 43 6.28e-05 0.353000 1.45e-03
RHOF GTPASE CYCLE 41 9.74e-05 0.352000 2.05e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 2.38e-02 0.349000 1.07e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 3.01e-02 0.347000 1.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 2.94e-05 0.345000 8.65e-04
ACYL CHAIN REMODELLING OF PG 10 5.97e-02 0.344000 1.94e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.23e-05 0.343000 7.51e-04
RHOU GTPASE CYCLE 34 5.35e-04 0.343000 7.16e-03
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 6.55e-03 0.343000 4.52e-02
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS 10 6.07e-02 -0.343000 1.94e-01
RAP1 SIGNALLING 15 2.28e-02 0.340000 1.04e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.23e-02 0.339000 1.56e-01
CA DEPENDENT EVENTS 36 4.51e-04 0.338000 6.25e-03
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 15 2.42e-02 0.336000 1.07e-01
G PROTEIN MEDIATED EVENTS 52 3.04e-05 0.334000 8.65e-04
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 1.48e-02 0.332000 7.70e-02
DNA METHYLATION 23 6.01e-03 -0.331000 4.26e-02
NCAM1 INTERACTIONS 42 2.20e-04 -0.330000 3.59e-03
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 2.79e-02 0.328000 1.17e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.88e-02 0.326000 1.19e-01
PEROXISOMAL LIPID METABOLISM 27 3.49e-03 0.325000 2.89e-02
GLUTAMATE AND GLUTAMINE METABOLISM 13 4.26e-02 0.325000 1.56e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 3.04e-02 0.323000 1.23e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 53 5.37e-05 -0.321000 1.35e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.58e-02 0.320000 8.00e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 5.68e-03 0.320000 4.08e-02
SIGNALING BY HIPPO 20 1.39e-02 0.318000 7.45e-02
ACTIVATION OF SMO 16 2.85e-02 0.316000 1.19e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.23e-02 0.313000 2.17e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 19 1.83e-02 0.313000 8.84e-02
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 24 8.35e-03 -0.311000 5.35e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 5.32e-03 0.310000 3.91e-02
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 2.11e-04 0.309000 3.50e-03
RAF ACTIVATION 34 1.85e-03 0.309000 1.82e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 1.05e-02 -0.308000 6.30e-02
BIOTIN TRANSPORT AND METABOLISM 11 7.69e-02 0.308000 2.22e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 1.91e-03 -0.308000 1.86e-02
IRE1ALPHA ACTIVATES CHAPERONES 50 2.10e-04 0.303000 3.50e-03
EPHRIN SIGNALING 19 2.26e-02 0.302000 1.03e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 4.02e-07 -0.301000 2.50e-05
ERKS ARE INACTIVATED 13 6.07e-02 0.300000 1.94e-01
CONDENSATION OF PROPHASE CHROMOSOMES 30 4.41e-03 -0.300000 3.42e-02
O LINKED GLYCOSYLATION OF MUCINS 41 9.25e-04 0.299000 1.09e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 5.37e-02 0.298000 1.82e-01
INOSITOL PHOSPHATE METABOLISM 46 5.03e-04 0.297000 6.81e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 6.45e-02 0.296000 2.01e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 3.81e-03 0.296000 3.07e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 7.73e-02 0.295000 2.23e-01
COLLAGEN CHAIN TRIMERIZATION 41 1.11e-03 -0.294000 1.26e-02
EUKARYOTIC TRANSLATION ELONGATION 87 2.12e-06 -0.294000 1.19e-04
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 2.05e-02 0.292000 9.76e-02
NEGATIVE REGULATION OF MET ACTIVITY 20 2.38e-02 0.292000 1.07e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 4.40e-02 -0.291000 1.60e-01
CD28 CO STIMULATION 31 5.19e-03 0.290000 3.84e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 6.04e-02 0.290000 1.94e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 7.04e-02 0.290000 2.15e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 1.09e-02 0.289000 6.41e-02
BETA CATENIN PHOSPHORYLATION CASCADE 16 4.69e-02 0.287000 1.67e-01
DAG AND IP3 SIGNALING 40 1.71e-03 0.287000 1.75e-02
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 5.51e-02 -0.286000 1.85e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 1.05e-01 -0.283000 2.74e-01
RHOB GTPASE CYCLE 69 5.02e-05 0.282000 1.29e-03
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 1.23e-01 0.281000 3.05e-01
PI METABOLISM 79 1.58e-05 0.281000 5.81e-04
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 2.58e-02 0.281000 1.11e-01
GLYCOGEN METABOLISM 25 1.54e-02 0.280000 7.89e-02
SYNTHESIS OF PA 29 9.09e-03 0.280000 5.70e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.35e-03 0.279000 1.43e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 4.03e-02 0.279000 1.51e-01
COMPLEX I BIOGENESIS 56 3.11e-04 -0.279000 4.60e-03
PARASITE INFECTION 54 4.04e-04 0.278000 5.69e-03
REGULATION OF IFNG SIGNALING 13 8.40e-02 0.277000 2.35e-01
RHOG GTPASE CYCLE 74 3.86e-05 0.277000 1.01e-03
REGULATION OF TP53 EXPRESSION AND DEGRADATION 34 5.43e-03 0.276000 3.95e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 14 7.46e-02 0.275000 2.19e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 26 1.52e-02 0.275000 7.83e-02
NUCLEAR IMPORT OF REV PROTEIN 32 7.24e-03 0.274000 4.90e-02
THE PHOTOTRANSDUCTION CASCADE 22 2.63e-02 -0.274000 1.12e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 3.01e-02 0.273000 1.22e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 1.59e-04 0.273000 2.98e-03
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 14 7.87e-02 0.271000 2.26e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.04e-01 0.271000 2.74e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 2.59e-02 0.268000 1.11e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 8.33e-02 0.267000 2.34e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 6.22e-03 0.267000 4.34e-02
GLYCOGEN SYNTHESIS 14 8.54e-02 0.266000 2.38e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 15 7.51e-02 0.265000 2.19e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 1.20e-02 0.265000 6.90e-02
RHOJ GTPASE CYCLE 55 6.83e-04 0.265000 8.65e-03
SPRY REGULATION OF FGF SIGNALING 16 6.80e-02 0.264000 2.10e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 5.30e-02 0.263000 1.81e-01
NEPHRIN FAMILY INTERACTIONS 23 2.88e-02 0.263000 1.19e-01
CELLULAR HEXOSE TRANSPORT 12 1.14e-01 0.263000 2.91e-01
AMINE LIGAND BINDING RECEPTORS 29 1.46e-02 0.262000 7.64e-02
VLDLR INTERNALISATION AND DEGRADATION 12 1.17e-01 0.261000 2.96e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 8.05e-04 0.261000 9.68e-03
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.59e-04 0.261000 2.98e-03
DCC MEDIATED ATTRACTIVE SIGNALING 14 9.12e-02 0.261000 2.47e-01
VXPX CARGO TARGETING TO CILIUM 19 4.93e-02 0.261000 1.73e-01
RNA POLYMERASE III CHAIN ELONGATION 18 5.60e-02 -0.260000 1.86e-01
LYSINE CATABOLISM 11 1.35e-01 0.260000 3.25e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 1.25e-02 0.259000 7.14e-02
ACTIVATION OF RAC1 13 1.07e-01 0.258000 2.77e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 14 9.44e-02 0.258000 2.53e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 7.36e-03 0.258000 4.95e-02
P75NTR REGULATES AXONOGENESIS 10 1.60e-01 0.257000 3.59e-01
DISEASES OF DNA REPAIR 11 1.40e-01 0.257000 3.33e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 1.60e-01 0.257000 3.59e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.60e-01 0.257000 3.59e-01
CD28 DEPENDENT VAV1 PATHWAY 11 1.41e-01 0.256000 3.33e-01
PRE NOTCH PROCESSING IN GOLGI 18 5.99e-02 0.256000 1.94e-01
ERK MAPK TARGETS 22 3.79e-02 0.256000 1.45e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 15 8.78e-02 -0.255000 2.43e-01
PRC2 METHYLATES HISTONES AND DNA 32 1.28e-02 -0.254000 7.26e-02
SCAVENGING BY CLASS A RECEPTORS 14 9.96e-02 -0.254000 2.65e-01
ACYL CHAIN REMODELLING OF PE 18 6.21e-02 0.254000 1.97e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.28e-01 0.254000 3.12e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 7.55e-03 0.254000 5.02e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 3.96e-02 0.253000 1.50e-01
PHOSPHOLIPID METABOLISM 187 2.54e-09 0.253000 3.00e-07
RESPONSE OF MTB TO PHAGOCYTOSIS 21 4.57e-02 0.252000 1.64e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 1.73e-03 0.251000 1.75e-02
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 5.21e-02 0.251000 1.80e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 1.71e-01 -0.250000 3.73e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 1.51e-01 -0.250000 3.48e-01
DERMATAN SULFATE BIOSYNTHESIS 11 1.52e-01 0.249000 3.49e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.26e-02 0.249000 1.03e-01
MTOR SIGNALLING 40 6.56e-03 0.248000 4.52e-02
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 1.75e-01 0.248000 3.79e-01
SYNTHESIS OF PE 13 1.22e-01 0.247000 3.04e-01
DEADENYLATION OF MRNA 25 3.32e-02 0.246000 1.31e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 2.18e-02 0.246000 1.02e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.25e-01 -0.246000 3.07e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 7.15e-02 0.245000 2.17e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 1.26e-01 0.245000 3.09e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 84 1.13e-04 0.244000 2.26e-03
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 7.85e-05 0.244000 1.68e-03
GLUTATHIONE SYNTHESIS AND RECYCLING 11 1.62e-01 0.243000 3.60e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 1.45e-02 0.242000 7.62e-02
NONSENSE MEDIATED DECAY NMD 109 1.29e-05 -0.242000 5.22e-04
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 1.85e-01 -0.242000 3.92e-01
KILLING MECHANISMS 11 1.66e-01 -0.241000 3.66e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 5.56e-02 0.241000 1.86e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 2.72e-02 0.241000 1.14e-01
NRAGE SIGNALS DEATH THROUGH JNK 56 1.81e-03 0.241000 1.79e-02
TELOMERE C STRAND SYNTHESIS INITIATION 13 1.33e-01 0.241000 3.21e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 1.83e-04 0.241000 3.32e-03
TRIGLYCERIDE BIOSYNTHESIS 10 1.88e-01 0.240000 3.97e-01
RAC2 GTPASE CYCLE 88 9.92e-05 0.240000 2.05e-03
RND2 GTPASE CYCLE 39 9.68e-03 0.239000 5.91e-02
MITOTIC TELOPHASE CYTOKINESIS 13 1.35e-01 0.239000 3.25e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 27 3.17e-02 -0.239000 1.28e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 23 4.80e-02 0.238000 1.70e-01
SIGNALING BY WNT IN CANCER 31 2.20e-02 0.238000 1.02e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 9.09e-02 0.237000 2.47e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 4.51e-02 0.236000 1.62e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 1.03e-04 0.236000 2.09e-03
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 2.33e-02 0.235000 1.06e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 25 4.17e-02 -0.235000 1.55e-01
RHOC GTPASE CYCLE 74 4.73e-04 0.235000 6.48e-03
TBC RABGAPS 43 7.69e-03 0.235000 5.06e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 1.29e-01 0.235000 3.13e-01
UNWINDING OF DNA 12 1.61e-01 0.234000 3.60e-01
FORMATION OF THE CORNIFIED ENVELOPE 31 2.42e-02 -0.234000 1.07e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 2.63e-05 0.233000 7.96e-04
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 2.99e-02 0.233000 1.22e-01
PEROXISOMAL PROTEIN IMPORT 59 2.07e-03 0.232000 1.95e-02
CYTOSOLIC TRNA AMINOACYLATION 24 4.94e-02 0.232000 1.73e-01
RESOLUTION OF SISTER CHROMATID COHESION 102 5.49e-05 0.231000 1.35e-03
INHIBITION OF DNA RECOMBINATION AT TELOMERE 38 1.37e-02 -0.231000 7.45e-02
SUMOYLATION OF SUMOYLATION PROTEINS 33 2.21e-02 0.230000 1.02e-01
MEMBRANE TRAFFICKING 581 3.96e-21 0.230000 4.66e-18
TRNA AMINOACYLATION 42 1.02e-02 0.229000 6.13e-02
RESPIRATORY ELECTRON TRANSPORT 102 6.43e-05 -0.229000 1.46e-03
ASPARAGINE N LINKED GLYCOSYLATION 285 3.17e-11 0.229000 6.23e-09
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 2.11e-01 0.228000 4.31e-01
RHOQ GTPASE CYCLE 58 2.65e-03 0.228000 2.35e-02
PYRUVATE METABOLISM 27 4.03e-02 0.228000 1.51e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 6.12e-06 0.227000 3.00e-04
LYSOSOME VESICLE BIOGENESIS 33 2.40e-02 0.227000 1.07e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 1.57e-01 0.227000 3.56e-01
HEME BIOSYNTHESIS 13 1.57e-01 0.227000 3.56e-01
OPIOID SIGNALLING 87 2.60e-04 0.227000 4.04e-03
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 2.23e-02 0.226000 1.03e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 1.58e-02 0.226000 8.00e-02
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 1.18e-07 0.226000 9.96e-06
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 16 1.19e-01 0.225000 2.98e-01
G0 AND EARLY G1 25 5.11e-02 0.225000 1.77e-01
G1 S SPECIFIC TRANSCRIPTION 26 4.69e-02 0.225000 1.67e-01
REGULATION OF KIT SIGNALING 16 1.19e-01 0.225000 2.98e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 3.92e-07 0.225000 2.50e-05
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 85 3.38e-04 0.225000 4.92e-03
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 1.97e-01 0.225000 4.07e-01
RMTS METHYLATE HISTONE ARGININES 46 8.40e-03 -0.225000 5.35e-02
GLYCOGEN STORAGE DISEASES 12 1.78e-01 0.225000 3.83e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 8.24e-02 0.224000 2.32e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.21e-01 0.224000 4.41e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.01e-01 -0.223000 2.69e-01
MTORC1 MEDIATED SIGNALLING 24 5.92e-02 0.222000 1.93e-01
PECAM1 INTERACTIONS 12 1.82e-01 0.222000 3.88e-01
RAB REGULATION OF TRAFFICKING 119 3.08e-05 0.221000 8.65e-04
BLOOD GROUP SYSTEMS BIOSYNTHESIS 15 1.39e-01 0.221000 3.31e-01
GAP JUNCTION DEGRADATION 11 2.06e-01 0.220000 4.21e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 6.20e-02 0.220000 1.97e-01
RHOD GTPASE CYCLE 51 6.63e-03 0.220000 4.54e-02
NUCLEAR ENVELOPE BREAKDOWN 49 7.94e-03 0.219000 5.17e-02
SIGNALLING TO ERKS 34 2.70e-02 0.219000 1.14e-01
REGULATION OF SIGNALING BY CBL 22 7.58e-02 0.219000 2.20e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 1.32e-02 0.218000 7.32e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 9.97e-02 -0.218000 2.65e-01
TIGHT JUNCTION INTERACTIONS 16 1.31e-01 0.218000 3.18e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 1.92e-01 0.218000 4.01e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 1.45e-01 0.218000 3.39e-01
PLATELET CALCIUM HOMEOSTASIS 26 5.58e-02 0.217000 1.86e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 1.94e-01 -0.217000 4.03e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 8.59e-06 0.216000 3.75e-04
HIV ELONGATION ARREST AND RECOVERY 32 3.43e-02 -0.216000 1.34e-01
RHOA GTPASE CYCLE 143 8.44e-06 0.216000 3.75e-04
GLYCOSAMINOGLYCAN METABOLISM 113 7.73e-05 0.215000 1.68e-03
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 6.82e-02 0.215000 2.10e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 3.53e-02 0.215000 1.37e-01
METABOLISM OF COFACTORS 19 1.05e-01 -0.215000 2.74e-01
BILE ACID AND BILE SALT METABOLISM 26 5.82e-02 0.215000 1.91e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 13 1.80e-01 -0.215000 3.85e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 1.75e-02 0.214000 8.63e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 6.91e-02 0.214000 2.12e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 75 1.34e-03 0.214000 1.43e-02
GABA RECEPTOR ACTIVATION 55 6.04e-03 0.214000 4.26e-02
SLC TRANSPORTER DISORDERS 76 1.27e-03 0.214000 1.40e-02
GOLGI TO ER RETROGRADE TRANSPORT 119 5.70e-05 0.214000 1.37e-03
RHOBTB1 GTPASE CYCLE 23 7.70e-02 0.213000 2.22e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 2.70e-02 0.213000 1.14e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.02e-01 0.213000 4.17e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 102 2.10e-04 0.212000 3.50e-03
KERATINIZATION 32 3.82e-02 -0.212000 1.46e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 9.31e-02 0.212000 2.50e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 2.25e-01 0.211000 4.48e-01
SARS COV 2 INFECTION 65 3.35e-03 0.210000 2.82e-02
HDACS DEACETYLATE HISTONES 49 1.09e-02 -0.210000 6.41e-02
DARPP 32 EVENTS 23 8.09e-02 0.210000 2.29e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.13e-01 0.210000 2.89e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 50 1.02e-02 -0.210000 6.13e-02
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 1.11e-02 0.210000 6.51e-02
PLASMA LIPOPROTEIN CLEARANCE 28 5.50e-02 0.210000 1.85e-01
BUDDING AND MATURATION OF HIV VIRION 27 5.97e-02 0.209000 1.94e-01
RND1 GTPASE CYCLE 38 2.56e-02 0.209000 1.11e-01
INTERLEUKIN 17 SIGNALING 68 2.90e-03 0.209000 2.48e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.31e-01 0.208000 4.53e-01
GPVI MEDIATED ACTIVATION CASCADE 31 4.48e-02 0.208000 1.62e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 182 1.33e-06 0.208000 7.81e-05
BASE EXCISION REPAIR AP SITE FORMATION 32 4.22e-02 -0.207000 1.56e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 2.15e-01 0.207000 4.34e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 1.02e-01 0.206000 2.69e-01
SIGNALING BY BMP 25 7.48e-02 0.206000 2.19e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 1.03e-01 0.206000 2.71e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.61e-04 -0.205000 4.04e-03
TRANSMISSION ACROSS CHEMICAL SYNAPSES 244 3.73e-08 0.205000 3.66e-06
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 1.57e-01 -0.204000 3.56e-01
FATTY ACID METABOLISM 147 2.16e-05 0.203000 7.50e-04
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.26e-01 0.203000 3.09e-01
INTEGRIN SIGNALING 24 8.56e-02 0.203000 2.38e-01
SARS COV 1 INFECTION 48 1.55e-02 0.202000 7.92e-02
VESICLE MEDIATED TRANSPORT 613 1.95e-17 0.201000 7.67e-15
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 1.63e-01 0.201000 3.62e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 1.65e-01 0.201000 3.64e-01
KERATAN SULFATE BIOSYNTHESIS 24 8.89e-02 0.201000 2.45e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 5.81e-02 0.200000 1.91e-01
METABOLISM OF CARBOHYDRATES 260 3.05e-08 0.200000 3.27e-06
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.17e-04 -0.200000 2.30e-03
EPHB MEDIATED FORWARD SIGNALING 42 2.53e-02 0.200000 1.10e-01
PENTOSE PHOSPHATE PATHWAY 13 2.13e-01 0.199000 4.33e-01
SIGNALING BY NTRK2 TRKB 24 9.09e-02 0.199000 2.47e-01
AUTOPHAGY 138 5.92e-05 0.198000 1.39e-03
MISMATCH REPAIR 15 1.84e-01 0.198000 3.91e-01
MITOTIC SPINDLE CHECKPOINT 97 7.52e-04 0.198000 9.23e-03
METABOLISM OF LIPIDS 618 5.42e-17 0.198000 1.60e-14
PURINE SALVAGE 12 2.36e-01 0.198000 4.56e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 33 4.98e-02 0.197000 1.74e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 2.02e-01 0.197000 4.17e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 49 1.72e-02 -0.197000 8.56e-02
KERATAN SULFATE KERATIN METABOLISM 30 6.28e-02 0.196000 1.97e-01
COPII MEDIATED VESICLE TRANSPORT 66 5.84e-03 0.196000 4.17e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 1.62e-01 0.196000 3.60e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 1.90e-01 0.196000 3.99e-01
NEUROTRANSMITTER RELEASE CYCLE 49 1.79e-02 0.196000 8.75e-02
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 35 4.54e-02 -0.196000 1.63e-01
LGI ADAM INTERACTIONS 14 2.05e-01 -0.195000 4.21e-01
NETRIN 1 SIGNALING 50 1.71e-02 0.195000 8.53e-02
INTERLEUKIN 6 SIGNALING 10 2.87e-01 0.195000 5.21e-01
GABA B RECEPTOR ACTIVATION 40 3.35e-02 0.194000 1.32e-01
FCERI MEDIATED MAPK ACTIVATION 28 7.56e-02 0.194000 2.20e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 2.66e-01 0.194000 4.97e-01
RECYCLING PATHWAY OF L1 40 3.44e-02 0.193000 1.34e-01
METABOLISM OF PORPHYRINS 19 1.45e-01 0.193000 3.39e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 7.20e-02 0.193000 2.17e-01
INTERLEUKIN 37 SIGNALING 18 1.57e-01 0.193000 3.56e-01
INTEGRATION OF ENERGY METABOLISM 100 8.88e-04 0.192000 1.06e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 2.14e-02 0.192000 1.01e-01
MEIOTIC RECOMBINATION 41 3.43e-02 -0.191000 1.34e-01
PEPTIDE HORMONE METABOLISM 62 9.44e-03 0.191000 5.82e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 9.26e-02 0.191000 2.50e-01
RND3 GTPASE CYCLE 38 4.26e-02 0.190000 1.56e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 1.39e-02 0.190000 7.45e-02
FORMATION OF APOPTOSOME 10 2.99e-01 0.190000 5.34e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 1.78e-03 0.190000 1.78e-02
HS GAG BIOSYNTHESIS 30 7.27e-02 0.189000 2.17e-01
COSTIMULATION BY THE CD28 FAMILY 50 2.08e-02 0.189000 9.86e-02
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 3.04e-01 0.188000 5.39e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 3.04e-01 0.188000 5.39e-01
EUKARYOTIC TRANSLATION INITIATION 114 5.52e-04 -0.187000 7.30e-03
UNFOLDED PROTEIN RESPONSE UPR 86 2.80e-03 0.187000 2.41e-02
EFFECTS OF PIP2 HYDROLYSIS 27 9.59e-02 0.185000 2.57e-01
SIGNALING BY NTRKS 130 2.76e-04 0.185000 4.17e-03
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 97 1.73e-03 0.184000 1.75e-02
CIRCADIAN CLOCK 68 8.67e-03 0.184000 5.49e-02
RAC3 GTPASE CYCLE 91 2.42e-03 0.184000 2.23e-02
G ALPHA 12 13 SIGNALLING EVENTS 76 5.58e-03 0.184000 4.03e-02
PROCESSING AND ACTIVATION OF SUMO 10 3.16e-01 0.183000 5.52e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 2.21e-01 0.183000 4.41e-01
TRNA PROCESSING IN THE NUCLEUS 56 1.83e-02 0.182000 8.84e-02
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 2.71e-03 0.182000 2.36e-02
SIALIC ACID METABOLISM 32 7.49e-02 0.182000 2.19e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 2.75e-01 -0.182000 5.07e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 5.60e-02 0.182000 1.86e-01
CELLULAR RESPONSE TO HEAT STRESS 94 2.51e-03 0.180000 2.25e-02
MHC CLASS II ANTIGEN PRESENTATION 102 1.67e-03 0.180000 1.72e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT 193 1.63e-05 0.180000 5.81e-04
RHO GTPASES ACTIVATE KTN1 11 3.01e-01 0.180000 5.36e-01
MYD88 INDEPENDENT TLR4 CASCADE 93 2.75e-03 0.180000 2.38e-02
HDR THROUGH MMEJ ALT NHEJ 10 3.25e-01 0.180000 5.64e-01
SYNTHESIS OF PC 26 1.14e-01 0.179000 2.91e-01
RHO GTPASES ACTIVATE FORMINS 119 7.50e-04 0.179000 9.23e-03
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 3.28e-01 0.179000 5.67e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 9.06e-02 0.179000 2.47e-01
SIGNALING BY RETINOIC ACID 33 7.64e-02 0.178000 2.22e-01
RAC1 GTPASE CYCLE 180 3.81e-05 0.178000 1.01e-03
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 3.30e-01 0.178000 5.68e-01
BASIGIN INTERACTIONS 22 1.48e-01 0.178000 3.42e-01
SIGNALING BY ACTIVIN 12 2.86e-01 0.178000 5.20e-01
TNF SIGNALING 43 4.42e-02 0.177000 1.60e-01
INTEGRIN CELL SURFACE INTERACTIONS 75 7.94e-03 -0.177000 5.17e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 7.00e-02 -0.177000 2.14e-01
DNA STRAND ELONGATION 32 8.34e-02 0.177000 2.34e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 2.70e-01 0.177000 5.02e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 1.53e-01 0.176000 3.50e-01
GP1B IX V ACTIVATION SIGNALLING 11 3.12e-01 -0.176000 5.49e-01
CS DS DEGRADATION 14 2.57e-01 0.175000 4.85e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 27 1.16e-01 -0.175000 2.95e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.47e-01 -0.175000 3.40e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 2.28e-01 0.174000 4.51e-01
GLUCONEOGENESIS 27 1.18e-01 0.174000 2.98e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 4.39e-02 0.174000 1.60e-01
SIGNALING BY HEDGEHOG 141 3.75e-04 0.174000 5.39e-03
SIGNALING BY VEGF 104 2.26e-03 0.173000 2.09e-02
RHO GTPASE CYCLE 425 9.79e-10 0.173000 1.65e-07
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 1.60e-01 0.173000 3.59e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.18e-01 -0.173000 4.38e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 47 4.09e-02 -0.172000 1.53e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 225 8.54e-06 0.172000 3.75e-04
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 1.80e-02 0.172000 8.78e-02
RAB GERANYLGERANYLATION 57 2.48e-02 0.172000 1.09e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.66e-02 -0.172000 8.35e-02
SIGNALING BY SCF KIT 41 5.73e-02 0.172000 1.89e-01
IRON UPTAKE AND TRANSPORT 52 3.24e-02 0.172000 1.29e-01
ERYTHROPOIETIN ACTIVATES RAS 13 2.85e-01 0.171000 5.19e-01
COLLAGEN DEGRADATION 52 3.26e-02 -0.171000 1.29e-01
SIGNALING BY MET 74 1.09e-02 0.171000 6.41e-02
TRIGLYCERIDE METABOLISM 24 1.46e-01 0.171000 3.40e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 4.72e-03 0.170000 3.59e-02
CELL CELL COMMUNICATION 106 2.66e-03 0.169000 2.35e-02
INTERLEUKIN 10 SIGNALING 20 1.91e-01 -0.169000 4.01e-01
RNA POLYMERASE I PROMOTER ESCAPE 50 3.91e-02 -0.169000 1.48e-01
G ALPHA Z SIGNALLING EVENTS 44 5.30e-02 0.169000 1.81e-01
GLUCOSE METABOLISM 81 8.84e-03 0.168000 5.57e-02
FGFR1 MUTANT RECEPTOR ACTIVATION 26 1.37e-01 0.168000 3.29e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 7.13e-03 0.168000 4.85e-02
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 4.73e-03 0.168000 3.59e-02
SHC MEDIATED CASCADE FGFR4 13 2.96e-01 -0.167000 5.32e-01
CARGO CONCENTRATION IN THE ER 31 1.07e-01 0.167000 2.77e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 2.64e-01 0.167000 4.94e-01
AMINO ACIDS REGULATE MTORC1 51 3.96e-02 0.167000 1.50e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 162 2.73e-04 -0.166000 4.17e-03
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 1.30e-01 -0.165000 3.16e-01
PROTEIN METHYLATION 17 2.40e-01 0.165000 4.61e-01
DEATH RECEPTOR SIGNALLING 134 1.01e-03 0.165000 1.16e-02
METABOLISM OF STEROIDS 116 2.23e-03 0.164000 2.08e-02
SIGNALING BY EGFR 47 5.28e-02 0.163000 1.81e-01
SIGNAL AMPLIFICATION 31 1.16e-01 0.163000 2.95e-01
SELENOAMINO ACID METABOLISM 108 3.48e-03 -0.163000 2.89e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 52 4.24e-02 -0.163000 1.56e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 30 1.24e-01 0.162000 3.05e-01
MUCOPOLYSACCHARIDOSES 11 3.53e-01 0.162000 5.89e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 65 2.44e-02 -0.162000 1.07e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 1.50e-02 0.161000 7.79e-02
SULFUR AMINO ACID METABOLISM 23 1.80e-01 0.161000 3.85e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 14 2.97e-01 0.161000 5.32e-01
HYALURONAN METABOLISM 15 2.80e-01 0.161000 5.13e-01
MITOCHONDRIAL TRANSLATION 93 7.48e-03 -0.161000 5.01e-02
MITOTIC METAPHASE AND ANAPHASE 207 7.19e-05 0.160000 1.60e-03
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 1.74e-02 0.160000 8.63e-02
SEMA3A PAK DEPENDENT AXON REPULSION 16 2.69e-01 0.160000 5.01e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 3.60e-01 -0.160000 5.96e-01
REGULATION OF TNFR1 SIGNALING 34 1.08e-01 0.159000 2.78e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 2.90e-02 -0.159000 1.19e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.71e-01 -0.159000 5.02e-01
CYCLIN D ASSOCIATED EVENTS IN G1 46 6.20e-02 0.159000 1.97e-01
SENSORY PERCEPTION 158 6.00e-04 -0.158000 7.77e-03
EGFR DOWNREGULATION 28 1.47e-01 0.158000 3.40e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 3.45e-01 0.158000 5.80e-01
RHOBTB2 GTPASE CYCLE 23 1.93e-01 0.157000 4.03e-01
CDC42 GTPASE CYCLE 155 7.64e-04 0.157000 9.28e-03
REGULATION OF INSULIN SECRETION 72 2.16e-02 0.157000 1.01e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 631 2.39e-11 0.156000 5.62e-09
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 1.46e-01 0.156000 3.39e-01
NEURONAL SYSTEM 371 2.57e-07 0.156000 1.78e-05
PROTEIN UBIQUITINATION 70 2.42e-02 0.156000 1.07e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 2.40e-01 0.156000 4.61e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 3.31e-01 -0.156000 5.68e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 3.71e-01 0.156000 6.08e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 2.54e-01 0.155000 4.79e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 33 1.23e-01 -0.155000 3.05e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1226 1.18e-19 0.155000 6.97e-17
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 2.33e-01 0.154000 4.54e-01
INSULIN RECEPTOR RECYCLING 20 2.35e-01 0.154000 4.55e-01
LONG TERM POTENTIATION 23 2.03e-01 0.153000 4.17e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 107 6.14e-03 0.153000 4.31e-02
PI 3K CASCADE FGFR3 13 3.39e-01 0.153000 5.75e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 5.68e-02 0.153000 1.88e-01
NUCLEOBASE CATABOLISM 31 1.42e-01 0.152000 3.35e-01
RHO GTPASES ACTIVATE PKNS 50 6.28e-02 -0.152000 1.97e-01
SIGNALING BY KIT IN DISEASE 20 2.40e-01 0.152000 4.61e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 1.60e-03 0.151000 1.68e-02
INTERLEUKIN RECEPTOR SHC SIGNALING 20 2.43e-01 0.151000 4.64e-01
SIGNAL TRANSDUCTION BY L1 21 2.33e-01 0.150000 4.54e-01
HOST INTERACTIONS OF HIV FACTORS 125 3.70e-03 0.150000 3.01e-02
PROTEIN LOCALIZATION 158 1.14e-03 0.150000 1.27e-02
MET PROMOTES CELL MOTILITY 39 1.05e-01 0.150000 2.74e-01
CD209 DC SIGN SIGNALING 18 2.71e-01 0.150000 5.02e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 8.76e-02 0.149000 2.43e-01
G ALPHA I SIGNALLING EVENTS 204 2.52e-04 0.149000 4.02e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 1.67e-01 0.148000 3.67e-01
METABOLISM OF NUCLEOTIDES 92 1.43e-02 0.148000 7.59e-02
TRANSCRIPTIONAL REGULATION BY RUNX1 182 5.89e-04 -0.148000 7.71e-03
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 5.38e-03 0.148000 3.94e-02
MYOGENESIS 25 2.01e-01 0.148000 4.16e-01
SEROTONIN RECEPTORS 10 4.19e-01 0.148000 6.48e-01
REGULATION OF BACH1 ACTIVITY 11 3.97e-01 0.148000 6.30e-01
SIGNALING BY FGFR3 35 1.32e-01 0.147000 3.19e-01
PROLACTIN RECEPTOR SIGNALING 11 3.99e-01 0.147000 6.31e-01
SELECTIVE AUTOPHAGY 71 3.23e-02 0.147000 1.29e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 3.46e-01 0.146000 5.81e-01
SHC1 EVENTS IN EGFR SIGNALING 11 4.03e-01 -0.145000 6.36e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.91e-01 0.145000 4.01e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 3.83e-01 0.145000 6.18e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 1.08e-01 0.145000 2.78e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 29 1.76e-01 -0.145000 3.80e-01
ACYL CHAIN REMODELLING OF PC 18 2.87e-01 0.145000 5.21e-01
TRANSPORT OF SMALL MOLECULES 586 2.25e-09 0.145000 2.95e-07
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.05e-01 0.144000 2.74e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 72 3.43e-02 0.144000 1.34e-01
PKMTS METHYLATE HISTONE LYSINES 51 7.49e-02 -0.144000 2.19e-01
RHOBTB GTPASE CYCLE 35 1.41e-01 0.144000 3.33e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 2.05e-01 0.144000 4.20e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 2.33e-01 0.144000 4.54e-01
PYRIMIDINE SALVAGE 10 4.31e-01 0.144000 6.56e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 4.13e-01 0.143000 6.42e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 21 2.58e-01 0.142000 4.85e-01
LAGGING STRAND SYNTHESIS 20 2.71e-01 0.142000 5.02e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 2.09e-01 0.142000 4.27e-01
RRNA PROCESSING 194 6.48e-04 -0.142000 8.30e-03
SIGNALING BY EGFR IN CANCER 22 2.49e-01 -0.142000 4.72e-01
SEPARATION OF SISTER CHROMATIDS 166 1.62e-03 0.142000 1.69e-02
SNRNP ASSEMBLY 51 8.08e-02 0.141000 2.29e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 4.39e-01 0.141000 6.58e-01
RNA POLYMERASE III TRANSCRIPTION 41 1.18e-01 -0.141000 2.98e-01
ONCOGENIC MAPK SIGNALING 77 3.24e-02 0.141000 1.29e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.14e-01 0.141000 4.33e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 3.66e-02 0.141000 1.41e-01
SIGNALING BY GPCR 486 1.28e-07 0.140000 1.01e-05
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 4.44e-01 0.140000 6.62e-01
NOD1 2 SIGNALING PATHWAY 35 1.52e-01 0.140000 3.49e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.42e-01 -0.140000 3.35e-01
MITOPHAGY 29 1.94e-01 0.139000 4.03e-01
SIGNALING BY FGFR2 IN DISEASE 37 1.43e-01 -0.139000 3.35e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 6.25e-02 0.139000 1.97e-01
PLASMA LIPOPROTEIN REMODELING 14 3.69e-01 0.139000 6.06e-01
TOLL LIKE RECEPTOR CASCADES 139 4.89e-03 0.138000 3.67e-02
CELLULAR RESPONSE TO STARVATION 146 4.06e-03 -0.138000 3.21e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 6.07e-02 0.138000 1.94e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 24 2.43e-01 0.138000 4.64e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 2.65e-01 0.137000 4.95e-01
NUCLEOTIDE SALVAGE 21 2.77e-01 0.137000 5.08e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 85 2.99e-02 0.136000 1.22e-01
SIGNALING BY FGFR1 IN DISEASE 33 1.77e-01 0.136000 3.81e-01
MITOTIC PROMETAPHASE 177 1.94e-03 0.135000 1.88e-02
INFLUENZA INFECTION 145 5.10e-03 -0.135000 3.80e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 3.10e-01 0.135000 5.46e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 7.45e-02 0.134000 2.19e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 2.29e-01 0.134000 4.51e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 4.04e-01 -0.134000 6.36e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 3.01e-01 0.134000 5.36e-01
CELL JUNCTION ORGANIZATION 73 4.87e-02 0.133000 1.72e-01
METABOLISM OF VITAMINS AND COFACTORS 152 4.62e-03 0.133000 3.56e-02
NEDDYLATION 217 7.47e-04 0.133000 9.23e-03
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 40 1.46e-01 -0.133000 3.39e-01
EPH EPHRIN SIGNALING 92 2.76e-02 0.133000 1.16e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 1.93e-01 0.133000 4.03e-01
ION TRANSPORT BY P TYPE ATPASES 50 1.05e-01 0.133000 2.74e-01
PEXOPHAGY 11 4.47e-01 0.132000 6.65e-01
ESTROGEN DEPENDENT GENE EXPRESSION 107 1.86e-02 -0.132000 8.95e-02
BASE EXCISION REPAIR 60 7.77e-02 -0.132000 2.23e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 2.29e-01 0.131000 4.51e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 2.47e-01 -0.131000 4.69e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 2.31e-01 -0.131000 4.53e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 2.33e-01 -0.130000 4.54e-01
CROSSLINKING OF COLLAGEN FIBRILS 15 3.83e-01 -0.130000 6.18e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 4.78e-01 -0.129000 6.92e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 4.59e-01 0.129000 6.79e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 1.45e-01 0.129000 3.39e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 6.70e-02 0.128000 2.08e-01
BIOLOGICAL OXIDATIONS 126 1.30e-02 0.128000 7.27e-02
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 94 3.17e-02 0.128000 1.28e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.66e-01 0.128000 3.66e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 3.34e-01 -0.128000 5.72e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 4.07e-01 0.128000 6.37e-01
NEUTROPHIL DEGRANULATION 389 1.61e-05 0.128000 5.81e-04
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 3.26e-01 0.127000 5.64e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 15 3.96e-01 0.127000 6.29e-01
CGMP EFFECTS 15 3.96e-01 -0.127000 6.29e-01
SIGNALING BY PTK6 51 1.19e-01 0.126000 2.98e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 1.53e-01 -0.126000 3.50e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 68 7.28e-02 -0.126000 2.17e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 1.20e-01 0.126000 3.01e-01
GLYCOLYSIS 67 7.50e-02 0.126000 2.19e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 4.71e-01 0.126000 6.88e-01
PHASE II CONJUGATION OF COMPOUNDS 64 8.24e-02 0.126000 2.32e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 6.40e-02 0.125000 2.00e-01
HEMOSTASIS 479 2.84e-06 0.125000 1.52e-04
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 13 4.35e-01 -0.125000 6.58e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 4.54e-01 0.125000 6.74e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 1.67e-01 0.125000 3.67e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 4.39e-01 -0.124000 6.58e-01
CELL CELL JUNCTION ORGANIZATION 48 1.38e-01 0.124000 3.30e-01
ADHERENS JUNCTIONS INTERACTIONS 30 2.41e-01 0.124000 4.61e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 2.13e-01 0.124000 4.33e-01
S PHASE 155 8.05e-03 0.123000 5.21e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 3.42e-01 -0.123000 5.77e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 2.17e-01 0.122000 4.38e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 69 8.00e-02 -0.122000 2.29e-01
REDUCTION OF CYTOSOLIC CA LEVELS 12 4.65e-01 0.122000 6.83e-01
TRIGLYCERIDE CATABOLISM 14 4.31e-01 0.122000 6.56e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 2.28e-01 0.121000 4.51e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 3.74e-01 0.121000 6.11e-01
REPRODUCTION 80 6.16e-02 -0.121000 1.97e-01
PI3K AKT SIGNALING IN CANCER 91 4.63e-02 0.121000 1.65e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 3.38e-01 0.121000 5.75e-01
PLASMA LIPOPROTEIN ASSEMBLY 12 4.69e-01 0.121000 6.87e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 5.46e-02 0.121000 1.84e-01
G ALPHA Q SIGNALLING EVENTS 155 9.67e-03 0.121000 5.91e-02
SUMOYLATION OF TRANSCRIPTION FACTORS 18 3.77e-01 -0.120000 6.11e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 4.73e-01 0.120000 6.90e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 143 1.38e-02 0.119000 7.45e-02
RRNA PROCESSING IN THE MITOCHONDRION 10 5.14e-01 0.119000 7.11e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 52 1.37e-01 -0.119000 3.29e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 3.23e-01 -0.119000 5.61e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 2.93e-01 0.119000 5.30e-01
HEDGEHOG ON STATE 82 6.41e-02 0.118000 2.00e-01
HIV INFECTION 221 2.47e-03 0.118000 2.24e-02
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 3.07e-01 0.118000 5.42e-01
ATTENUATION PHASE 23 3.29e-01 -0.118000 5.67e-01
CRISTAE FORMATION 31 2.58e-01 -0.117000 4.85e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 2.74e-01 0.117000 5.06e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 3.89e-01 0.117000 6.24e-01
MICRORNA MIRNA BIOGENESIS 24 3.21e-01 -0.117000 5.58e-01
PREGNENOLONE BIOSYNTHESIS 12 4.83e-01 -0.117000 6.95e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 4.65e-01 0.117000 6.83e-01
SIGNALLING TO RAS 20 3.66e-01 0.117000 6.02e-01
SHC MEDIATED CASCADE FGFR1 16 4.19e-01 -0.117000 6.48e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 4.06e-01 0.116000 6.37e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 3.05e-01 0.116000 5.39e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 5.05e-01 -0.116000 7.07e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 4.36e-01 0.116000 6.58e-01
REGULATION OF FZD BY UBIQUITINATION 19 3.82e-01 0.116000 6.18e-01
ECM PROTEOGLYCANS 68 9.97e-02 -0.116000 2.65e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 4.39e-01 0.115000 6.58e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 1.80e-01 0.115000 3.85e-01
INITIAL TRIGGERING OF COMPLEMENT 12 4.90e-01 0.115000 6.97e-01
TIE2 SIGNALING 17 4.12e-01 0.115000 6.42e-01
O LINKED GLYCOSYLATION 86 6.63e-02 0.115000 2.06e-01
ERBB2 ACTIVATES PTK6 SIGNALING 12 4.92e-01 0.114000 6.98e-01
ION HOMEOSTASIS 50 1.62e-01 0.114000 3.60e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 466 2.59e-05 0.114000 7.96e-04
INNATE IMMUNE SYSTEM 784 7.26e-08 0.114000 6.58e-06
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 5.16e-01 0.113000 7.12e-01
SODIUM CALCIUM EXCHANGERS 10 5.37e-01 0.113000 7.28e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 68 1.10e-01 0.112000 2.83e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 4.40e-01 -0.111000 6.58e-01
EARLY PHASE OF HIV LIFE CYCLE 13 4.87e-01 -0.111000 6.96e-01
COLLAGEN FORMATION 79 8.81e-02 -0.111000 2.43e-01
DISEASES OF PROGRAMMED CELL DEATH 57 1.47e-01 -0.111000 3.40e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 2.49e-01 0.111000 4.72e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 284 1.32e-03 0.111000 1.43e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 1.71e-01 0.111000 3.73e-01
TRANSLESION SYNTHESIS BY POLK 17 4.29e-01 -0.111000 6.56e-01
GLUTATHIONE CONJUGATION 30 2.94e-01 0.111000 5.30e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 5.44e-01 0.111000 7.30e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 17 4.30e-01 -0.110000 6.56e-01
RNA POLYMERASE I TRANSCRIPTION 70 1.10e-01 -0.110000 2.83e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 4.32e-01 0.110000 6.56e-01
SARS COV INFECTIONS 140 2.49e-02 0.110000 1.09e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 5.10e-01 -0.110000 7.09e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 2.41e-01 0.108000 4.61e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 4.99e-01 -0.108000 7.03e-01
ADAPTIVE IMMUNE SYSTEM 610 5.51e-06 0.108000 2.82e-04
HIV TRANSCRIPTION ELONGATION 42 2.26e-01 -0.108000 4.48e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 64 1.38e-01 0.107000 3.29e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 4.72e-01 0.107000 6.89e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 5.40e-01 0.107000 7.29e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 3.30e-01 0.106000 5.68e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 5.42e-01 -0.106000 7.29e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 86 8.91e-02 -0.106000 2.45e-01
NUCLEAR SIGNALING BY ERBB4 31 3.07e-01 0.106000 5.42e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 4.78e-01 0.106000 6.92e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 4.93e-01 -0.106000 6.98e-01
RHO GTPASES ACTIVATE CIT 18 4.39e-01 -0.105000 6.58e-01
ERBB2 REGULATES CELL MOTILITY 14 4.95e-01 0.105000 7.01e-01
PHASE 0 RAPID DEPOLARISATION 28 3.39e-01 -0.104000 5.75e-01
NICOTINATE METABOLISM 24 3.76e-01 0.104000 6.11e-01
RHO GTPASE EFFECTORS 253 4.40e-03 0.104000 3.42e-02
RHO GTPASES ACTIVATE IQGAPS 24 3.78e-01 0.104000 6.12e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 8.02e-02 0.104000 2.29e-01
SIGNALING BY NTRK3 TRKC 17 4.60e-01 -0.103000 6.80e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 2.68e-03 0.103000 2.36e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 4.37e-01 0.103000 6.58e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 2.79e-01 0.103000 5.11e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 5.22e-01 -0.103000 7.14e-01
FC EPSILON RECEPTOR FCERI SIGNALING 123 5.07e-02 0.102000 1.76e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 4.30e-01 0.102000 6.56e-01
HEDGEHOG LIGAND BIOGENESIS 61 1.70e-01 0.102000 3.71e-01
DISEASES OF METABOLISM 198 1.42e-02 0.101000 7.59e-02
M PHASE 343 1.33e-03 0.101000 1.43e-02
SMOOTH MUSCLE CONTRACTION 33 3.16e-01 -0.101000 5.52e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 106 7.29e-02 -0.101000 2.17e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 1.84e-01 0.101000 3.91e-01
L1CAM INTERACTIONS 108 7.08e-02 0.101000 2.16e-01
POLYMERASE SWITCHING 14 5.14e-01 0.101000 7.11e-01
HCMV INFECTION 106 7.35e-02 0.101000 2.19e-01
PLATELET AGGREGATION PLUG FORMATION 32 3.25e-01 0.101000 5.64e-01
SIGNALING BY ROBO RECEPTORS 207 1.30e-02 -0.100000 7.27e-02
G PROTEIN ACTIVATION 23 4.06e-01 -0.100000 6.37e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 9.89e-04 0.100000 1.14e-02
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 3.14e-01 0.099700 5.51e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 5.86e-01 -0.099400 7.64e-01
MITOTIC PROPHASE 97 9.10e-02 0.099400 2.47e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 5.51e-01 -0.099300 7.35e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 9.11e-02 0.099300 2.47e-01
CELL CYCLE MITOTIC 479 2.11e-04 0.099100 3.50e-03
CONSTITUTIVE SIGNALING BY EGFRVIII 15 5.09e-01 -0.098600 7.07e-01
SIGNALING BY LEPTIN 10 5.89e-01 0.098600 7.65e-01
P38MAPK EVENTS 13 5.39e-01 0.098400 7.28e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 53 2.16e-01 0.098300 4.35e-01
REPRESSION OF WNT TARGET GENES 14 5.25e-01 -0.098200 7.16e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 92 1.05e-01 0.097800 2.74e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 3.39e-01 -0.097800 5.75e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 4.62e-01 -0.097400 6.81e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 4.63e-01 0.097200 6.81e-01
FGFR1 LIGAND BINDING AND ACTIVATION 10 5.95e-01 -0.097100 7.68e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 347 2.07e-03 0.096400 1.95e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH 62 1.91e-01 -0.096200 4.01e-01
REGULATION OF IFNA SIGNALING 12 5.65e-01 0.096000 7.49e-01
HEDGEHOG OFF STATE 106 8.80e-02 0.096000 2.43e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 3.21e-01 0.095700 5.58e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 4.63e-01 0.094900 6.81e-01
NEUREXINS AND NEUROLIGINS 54 2.29e-01 0.094800 4.51e-01
RHO GTPASES ACTIVATE ROCKS 19 4.75e-01 -0.094700 6.90e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 5.72e-01 0.094300 7.53e-01
LATE ENDOSOMAL MICROAUTOPHAGY 31 3.68e-01 0.093400 6.06e-01
TRP CHANNELS 20 4.70e-01 0.093200 6.88e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 4.20e-01 -0.093100 6.49e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 3.58e-01 0.092500 5.94e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 4.75e-01 0.092400 6.90e-01
SIGNALING BY FGFR4 34 3.52e-01 0.092300 5.87e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 3.98e-01 0.092200 6.31e-01
ANCHORING FIBRIL FORMATION 14 5.50e-01 -0.092200 7.35e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 3.69e-01 0.091900 6.06e-01
LEISHMANIA INFECTION 198 2.67e-02 0.091400 1.14e-01
REGULATION OF TP53 ACTIVITY 152 5.24e-02 0.091200 1.81e-01
INWARDLY RECTIFYING K CHANNELS 32 3.73e-01 0.090900 6.11e-01
SIGNALING BY ERBB2 49 2.72e-01 0.090800 5.02e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 4.96e-01 -0.090200 7.01e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 5.21e-01 -0.089900 7.14e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 4.88e-01 -0.089600 6.96e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 2.19e-01 0.089500 4.39e-01
GPCR LIGAND BINDING 270 1.16e-02 0.089400 6.71e-02
RHOH GTPASE CYCLE 37 3.47e-01 0.089300 5.82e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 58 2.40e-01 0.089300 4.61e-01
SIGNALING BY INSULIN RECEPTOR 65 2.13e-01 0.089300 4.33e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 62 2.25e-01 0.089100 4.48e-01
LAMININ INTERACTIONS 29 4.07e-01 -0.089100 6.37e-01
SIGNALING BY FGFR4 IN DISEASE 11 6.10e-01 -0.088900 7.76e-01
PROCESSING OF SMDT1 16 5.39e-01 0.088800 7.28e-01
RORA ACTIVATES GENE EXPRESSION 18 5.14e-01 0.088800 7.11e-01
ION CHANNEL TRANSPORT 143 6.78e-02 0.088500 2.10e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 6.12e-01 -0.088300 7.76e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.96e-01 -0.088300 7.69e-01
DISEASES OF GLYCOSYLATION 124 9.01e-02 0.088200 2.47e-01
PLATELET HOMEOSTASIS 78 1.79e-01 0.088100 3.84e-01
HIV LIFE CYCLE 142 7.12e-02 0.087800 2.16e-01
TELOMERE MAINTENANCE 81 1.73e-01 -0.087700 3.75e-01
FLT3 SIGNALING 36 3.64e-01 0.087500 6.00e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 3.93e-01 -0.087200 6.29e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 4.18e-01 0.087000 6.47e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 3.95e-01 0.086800 6.29e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.99e-01 0.086700 5.34e-01
SIGNALING BY NOTCH3 48 3.02e-01 0.086100 5.37e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 5.07e-01 0.085800 7.07e-01
KERATAN SULFATE DEGRADATION 11 6.24e-01 0.085500 7.85e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 4.98e-01 -0.085400 7.02e-01
ONCOGENE INDUCED SENESCENCE 32 4.07e-01 0.084700 6.37e-01
MAPK FAMILY SIGNALING CASCADES 290 1.33e-02 0.084600 7.32e-02
TRANSLESION SYNTHESIS BY POLH 19 5.25e-01 -0.084200 7.16e-01
ACYL CHAIN REMODELLING OF PS 14 5.87e-01 0.083800 7.64e-01
HCMV LATE EVENTS 68 2.32e-01 0.083800 4.54e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 23 4.88e-01 -0.083500 6.96e-01
OXIDATIVE STRESS INDUCED SENESCENCE 81 1.97e-01 -0.083000 4.07e-01
CHOLESTEROL BIOSYNTHESIS 24 4.84e-01 0.082500 6.95e-01
RUNX3 REGULATES NOTCH SIGNALING 13 6.07e-01 0.082400 7.74e-01
ABC TRANSPORTER DISORDERS 70 2.34e-01 0.082300 4.54e-01
PYROPTOSIS 21 5.15e-01 -0.082100 7.11e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 3.41e-01 0.082100 5.76e-01
VIRAL MESSENGER RNA SYNTHESIS 42 3.60e-01 0.081600 5.96e-01
FRS MEDIATED FGFR3 SIGNALING 15 5.87e-01 0.081100 7.64e-01
INTERLEUKIN 1 FAMILY SIGNALING 123 1.21e-01 0.081100 3.01e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 33 4.21e-01 -0.081000 6.49e-01
AMYLOID FIBER FORMATION 61 2.74e-01 -0.080900 5.06e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 5.75e-01 -0.080900 7.57e-01
NEGATIVE REGULATION OF FLT3 14 6.02e-01 0.080600 7.71e-01
INTERLEUKIN 1 SIGNALING 96 1.73e-01 0.080500 3.75e-01
SIGNALING BY FGFR1 44 3.55e-01 0.080500 5.91e-01
SIGNALING BY THE B CELL RECEPTOR BCR 103 1.58e-01 0.080500 3.57e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 2.88e-01 -0.080000 5.22e-01
AQUAPORIN MEDIATED TRANSPORT 41 3.75e-01 0.080000 6.11e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 29 4.57e-01 0.079900 6.77e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 4.49e-01 0.079800 6.68e-01
METABOLISM OF POLYAMINES 57 3.01e-01 0.079200 5.36e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 5.51e-01 0.079100 7.35e-01
VISUAL PHOTOTRANSDUCTION 61 2.90e-01 -0.078400 5.24e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 6.52e-01 0.078400 8.09e-01
UB SPECIFIC PROCESSING PROTEASES 167 8.09e-02 0.078400 2.29e-01
NICOTINAMIDE SALVAGING 15 6.00e-01 0.078200 7.71e-01
DNA REPLICATION PRE INITIATION 80 2.30e-01 0.077700 4.51e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 4.85e-01 -0.077700 6.95e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 5.38e-01 0.077700 7.28e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 2.19e-01 -0.077600 4.39e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND 13 6.29e-01 -0.077500 7.90e-01
DNA DAMAGE RECOGNITION IN GG NER 38 4.09e-01 0.077400 6.38e-01
SIGNALING BY INTERLEUKINS 351 1.34e-02 0.077000 7.32e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 79 2.39e-01 0.076600 4.61e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 5.01e-01 0.076300 7.04e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 4.14e-01 -0.075600 6.44e-01
CILIUM ASSEMBLY 192 7.18e-02 0.075400 2.17e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 2.50e-01 0.075400 4.73e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 5.82e-01 0.075000 7.63e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.83e-01 0.074700 8.30e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 3.49e-01 0.074400 5.83e-01
FGFR2 ALTERNATIVE SPLICING 25 5.21e-01 -0.074200 7.14e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 4.84e-01 0.073900 6.95e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 5.69e-01 0.073500 7.53e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 118 1.69e-01 0.073300 3.71e-01
SIGNALING BY ERBB4 57 3.41e-01 0.073000 5.76e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 111 1.85e-01 -0.072900 3.92e-01
CELL CYCLE 597 2.44e-03 0.072800 2.23e-02
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 6.14e-01 -0.072800 7.76e-01
DEUBIQUITINATION 241 5.32e-02 0.072400 1.81e-01
METAL ION SLC TRANSPORTERS 25 5.32e-01 0.072200 7.24e-01
SIGNALING BY NOTCH1 75 2.81e-01 0.072000 5.14e-01
TRANSLATION 286 3.68e-02 -0.071900 1.42e-01
REGULATED NECROSIS 46 4.00e-01 -0.071800 6.32e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 66 3.14e-01 0.071700 5.51e-01
REGULATED PROTEOLYSIS OF P75NTR 12 6.68e-01 0.071600 8.24e-01
CELL CYCLE CHECKPOINTS 245 5.46e-02 0.071400 1.84e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 5.71e-01 0.071300 7.53e-01
SIGNALING BY FGFR2 IIIA TM 19 5.90e-01 -0.071300 7.65e-01
DNA REPLICATION 122 1.75e-01 0.071100 3.79e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 6.12e-01 0.071100 7.76e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 5.56e-01 0.070900 7.40e-01
FRS MEDIATED FGFR2 SIGNALING 19 5.93e-01 -0.070800 7.67e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.84e-01 0.070800 7.64e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 4.22e-01 0.070700 6.50e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.01e-01 0.070200 8.45e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 6.75e-01 0.069900 8.26e-01
METABOLISM OF FOLATE AND PTERINES 15 6.43e-01 0.069100 8.03e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 5.07e-01 -0.068900 7.07e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 5.43e-01 0.068900 7.30e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 5.23e-01 -0.068600 7.14e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 5.63e-01 -0.068300 7.46e-01
REGULATION OF RAS BY GAPS 66 3.38e-01 0.068200 5.75e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 6.71e-01 0.068100 8.26e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 66 3.39e-01 -0.068100 5.75e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 6.72e-01 0.067900 8.26e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 46 4.28e-01 -0.067600 6.56e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 5.84e-01 0.067500 7.64e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 4.97e-01 0.067400 7.01e-01
TRAFFICKING OF AMPA RECEPTORS 31 5.17e-01 0.067300 7.12e-01
MEIOSIS 67 3.44e-01 -0.066800 5.80e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 64 3.55e-01 -0.066800 5.91e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 6.77e-01 -0.066800 8.26e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 7.02e-01 0.066700 8.45e-01
INSULIN RECEPTOR SIGNALLING CASCADE 46 4.35e-01 0.066600 6.58e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 152 1.62e-01 -0.065700 3.60e-01
GENE SILENCING BY RNA 85 2.95e-01 -0.065700 5.31e-01
G2 M DNA DAMAGE CHECKPOINT 69 3.47e-01 -0.065500 5.82e-01
KINESINS 47 4.39e-01 0.065200 6.58e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 187 1.26e-01 0.064900 3.09e-01
DSCAM INTERACTIONS 11 7.10e-01 0.064800 8.50e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 6.99e-01 -0.064600 8.45e-01
REGULATION OF PTEN GENE TRANSCRIPTION 58 3.95e-01 0.064500 6.29e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 5.94e-01 0.064300 7.67e-01
CHROMOSOME MAINTENANCE 104 2.60e-01 -0.064000 4.87e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 5.89e-01 -0.063800 7.65e-01
INTERFERON ALPHA BETA SIGNALING 54 4.18e-01 -0.063800 6.47e-01
INTERLEUKIN 7 SIGNALING 19 6.31e-01 -0.063600 7.92e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 6.16e-01 0.063200 7.78e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 4.23e-01 0.063100 6.50e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 5.86e-01 -0.063000 7.64e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 6.44e-01 -0.062900 8.04e-01
PYRIMIDINE CATABOLISM 10 7.32e-01 -0.062600 8.71e-01
RESOLUTION OF D LOOP STRUCTURES 31 5.49e-01 -0.062200 7.35e-01
RET SIGNALING 38 5.08e-01 0.062100 7.07e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 317 5.84e-02 0.061900 1.91e-01
PURINE CATABOLISM 16 6.71e-01 0.061400 8.26e-01
TRNA PROCESSING 105 2.78e-01 0.061300 5.10e-01
MEIOTIC SYNAPSIS 43 4.98e-01 -0.059700 7.02e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 549 1.76e-02 0.059400 8.63e-02
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 60 4.27e-01 0.059400 6.55e-01
MRNA SPLICING 188 1.62e-01 -0.059100 3.60e-01
STRIATED MUSCLE CONTRACTION 26 6.05e-01 -0.058600 7.73e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 6.95e-01 0.058500 8.42e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 6.30e-01 0.058100 7.91e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 6.04e-01 0.057700 7.73e-01
VOLTAGE GATED POTASSIUM CHANNELS 38 5.39e-01 0.057600 7.28e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 6.12e-01 0.057500 7.76e-01
C TYPE LECTIN RECEPTORS CLRS 112 2.95e-01 0.057400 5.31e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 4.47e-01 -0.057200 6.65e-01
CRMPS IN SEMA3A SIGNALING 16 6.92e-01 -0.057100 8.40e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 6.08e-01 0.057000 7.75e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 6.75e-01 0.057000 8.26e-01
RESOLUTION OF ABASIC SITES AP SITES 38 5.43e-01 -0.057000 7.30e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 7.57e-01 0.056500 8.85e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 5.76e-01 -0.056300 7.57e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 7.47e-01 0.056200 8.80e-01
HCMV EARLY EVENTS 83 3.77e-01 0.056200 6.11e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 74 4.08e-01 -0.055700 6.37e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 21 6.61e-01 0.055300 8.18e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 4.62e-01 -0.054500 6.81e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.68e-01 0.054300 7.51e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 5.38e-01 0.054300 7.28e-01
G ALPHA S SIGNALLING EVENTS 107 3.33e-01 0.054200 5.71e-01
SIGNALING BY NOTCH2 33 5.91e-01 0.054000 7.65e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 6.05e-01 0.053700 7.73e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 284 1.23e-01 0.053300 3.04e-01
PROTEIN FOLDING 90 3.86e-01 0.052900 6.21e-01
GAP JUNCTION ASSEMBLY 21 6.75e-01 0.052800 8.26e-01
INFECTIOUS DISEASE 736 1.52e-02 0.052800 7.83e-02
INTRINSIC PATHWAY FOR APOPTOSIS 52 5.12e-01 0.052600 7.10e-01
TP53 REGULATES METABOLIC GENES 85 4.03e-01 -0.052500 6.36e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 4.89e-01 0.052100 6.96e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 5.89e-01 0.052000 7.65e-01
IRAK4 DEFICIENCY TLR2 4 14 7.37e-01 -0.051900 8.75e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.45e-01 -0.051400 4.67e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 33 6.11e-01 0.051200 7.76e-01
CARDIAC CONDUCTION 107 3.62e-01 0.051000 5.98e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 6.02e-01 -0.051000 7.71e-01
RAS PROCESSING 24 6.66e-01 0.050900 8.22e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 6.73e-01 0.050800 8.26e-01
MATURATION OF NUCLEOPROTEIN 10 7.81e-01 -0.050800 8.94e-01
TCR SIGNALING 101 3.84e-01 0.050100 6.19e-01
TNFR2 NON CANONICAL NF KB PATHWAY 82 4.35e-01 0.049900 6.58e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 4.36e-01 0.049200 6.58e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 5.22e-01 -0.049000 7.14e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 7.44e-01 -0.048800 8.80e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 7.53e-01 0.048600 8.83e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 6.76e-01 -0.048200 8.26e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 6.85e-01 0.047900 8.32e-01
OTHER SEMAPHORIN INTERACTIONS 19 7.18e-01 -0.047800 8.57e-01
HOMOLOGY DIRECTED REPAIR 111 3.87e-01 -0.047600 6.21e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 7.67e-01 0.047500 8.88e-01
PRE NOTCH EXPRESSION AND PROCESSING 67 5.02e-01 -0.047500 7.04e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 94 4.31e-01 0.047000 6.56e-01
EXTENSION OF TELOMERES 49 5.70e-01 0.046900 7.53e-01
APOPTOTIC EXECUTION PHASE 45 5.87e-01 0.046800 7.64e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 5.17e-01 0.046800 7.12e-01
GAB1 SIGNALOSOME 14 7.63e-01 0.046500 8.86e-01
INTERFERON GAMMA SIGNALING 76 4.84e-01 -0.046500 6.95e-01
STIMULI SENSING CHANNELS 76 4.85e-01 0.046400 6.95e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 7.57e-01 0.046100 8.85e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 5.41e-01 -0.046000 7.29e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 6.48e-01 0.045900 8.08e-01
FCERI MEDIATED NF KB ACTIVATION 76 4.91e-01 0.045800 6.97e-01
CYTOPROTECTION BY HMOX1 120 3.88e-01 -0.045600 6.23e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 6.99e-01 -0.045500 8.45e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 7.77e-01 0.045400 8.94e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 7.08e-01 0.045100 8.50e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 7.64e-01 -0.044800 8.86e-01
ENDOSOMAL VACUOLAR PATHWAY 10 8.06e-01 0.044800 9.14e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 7.83e-01 -0.044200 8.95e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 7.69e-01 -0.043800 8.89e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 6.73e-01 -0.043800 8.26e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 64 5.45e-01 -0.043800 7.30e-01
MAP2K AND MAPK ACTIVATION 36 6.50e-01 0.043700 8.09e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 7.12e-01 0.043500 8.52e-01
ZINC TRANSPORTERS 16 7.64e-01 0.043400 8.86e-01
PCP CE PATHWAY 89 4.80e-01 0.043400 6.93e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 6.49e-01 -0.043300 8.08e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 6.78e-01 0.043100 8.27e-01
UCH PROTEINASES 89 4.83e-01 -0.043000 6.95e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 7.61e-01 -0.042600 8.86e-01
COMPLEMENT CASCADE 26 7.08e-01 0.042400 8.50e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 8.10e-01 -0.041900 9.15e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 5.99e-01 -0.041800 7.71e-01
FRS MEDIATED FGFR4 SIGNALING 15 7.80e-01 -0.041700 8.94e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 7.81e-01 -0.041400 8.94e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 81 5.20e-01 0.041400 7.14e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 6.22e-01 0.041100 7.84e-01
POTASSIUM CHANNELS 90 5.03e-01 0.040900 7.05e-01
SIGNALING BY PDGFR IN DISEASE 20 7.52e-01 0.040800 8.83e-01
PROGRAMMED CELL DEATH 186 3.38e-01 0.040800 5.75e-01
IRS MEDIATED SIGNALLING 41 6.52e-01 0.040800 8.09e-01
HDMS DEMETHYLATE HISTONES 30 7.01e-01 -0.040500 8.45e-01
INTRAFLAGELLAR TRANSPORT 52 6.14e-01 0.040400 7.76e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 5.37e-01 0.040200 7.28e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 5.57e-01 0.040100 7.40e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 7.35e-01 0.039900 8.74e-01
SUMOYLATION 168 3.74e-01 0.039800 6.11e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 7.97e-01 0.039700 9.06e-01
CLEC7A DECTIN 1 SIGNALING 94 5.08e-01 0.039600 7.07e-01
DNA DOUBLE STRAND BREAK RESPONSE 55 6.14e-01 0.039400 7.76e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 4.86e-01 0.038800 6.96e-01
ASSEMBLY OF THE HIV VIRION 16 7.91e-01 0.038300 9.01e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 7.46e-01 -0.038300 8.80e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 6.18e-01 -0.038200 7.80e-01
METHYLATION 11 8.28e-01 0.037700 9.22e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 8.07e-01 0.037700 9.14e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 8.39e-01 -0.037100 9.27e-01
METABOLISM OF STEROID HORMONES 21 7.70e-01 0.036900 8.89e-01
CHROMATIN MODIFYING ENZYMES 222 3.48e-01 -0.036600 5.83e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 8.21e-01 0.036300 9.19e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 5.62e-01 -0.035800 7.46e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 7.58e-01 -0.035600 8.85e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 5.78e-01 0.035600 7.59e-01
INTERFERON SIGNALING 164 4.35e-01 0.035300 6.58e-01
METABOLISM OF RNA 645 1.28e-01 -0.035200 3.12e-01
ELASTIC FIBRE FORMATION 38 7.08e-01 0.035100 8.50e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 8.29e-01 0.034500 9.23e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 8.20e-01 0.033900 9.19e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 7.42e-01 -0.033700 8.80e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 8.54e-01 -0.033600 9.35e-01
PI 3K CASCADE FGFR2 17 8.11e-01 -0.033500 9.15e-01
PTEN REGULATION 133 5.07e-01 0.033400 7.07e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 6.02e-01 0.032800 7.71e-01
DISEASES OF IMMUNE SYSTEM 26 7.73e-01 -0.032700 8.92e-01
HSF1 DEPENDENT TRANSACTIVATION 33 7.47e-01 0.032500 8.80e-01
APOPTOSIS 164 4.75e-01 0.032300 6.90e-01
G1 S DNA DAMAGE CHECKPOINTS 65 6.53e-01 -0.032300 8.09e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 7.91e-01 0.031900 9.01e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 8.43e-01 0.031700 9.29e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 7.68e-01 0.031600 8.89e-01
ENOS ACTIVATION 11 8.60e-01 0.030800 9.36e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 8.66e-01 0.030800 9.39e-01
MITOTIC G2 G2 M PHASES 184 4.76e-01 0.030500 6.90e-01
SIGNALING BY WNT 272 3.91e-01 0.030300 6.26e-01
INFLAMMASOMES 19 8.20e-01 0.030100 9.19e-01
HSF1 ACTIVATION 25 7.96e-01 -0.029800 9.06e-01
DUAL INCISION IN TC NER 65 6.79e-01 -0.029700 8.27e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 6.81e-01 0.029700 8.29e-01
POTENTIAL THERAPEUTICS FOR SARS 77 6.53e-01 0.029700 8.09e-01
SIGNALING BY NUCLEAR RECEPTORS 228 4.44e-01 0.029500 6.62e-01
PHOSPHORYLATION OF THE APC C 17 8.36e-01 0.029100 9.27e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 86 6.42e-01 0.029000 8.03e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 7.48e-01 -0.029000 8.80e-01
PI 3K CASCADE FGFR1 16 8.42e-01 0.028900 9.29e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 8.52e-01 -0.028800 9.35e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 57 7.09e-01 0.028600 8.50e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 15 8.48e-01 0.028500 9.33e-01
MITOCHONDRIAL PROTEIN IMPORT 63 6.99e-01 0.028200 8.45e-01
CA2 PATHWAY 59 7.10e-01 -0.028000 8.50e-01
INTERLEUKIN 15 SIGNALING 12 8.69e-01 -0.027500 9.39e-01
PHASE 2 PLATEAU PHASE 10 8.81e-01 -0.027400 9.43e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 8.33e-01 0.027200 9.26e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.55e-01 -0.026400 9.35e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 8.69e-01 0.026400 9.39e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 8.70e-01 -0.026200 9.39e-01
MRNA SPLICING MINOR PATHWAY 52 7.44e-01 -0.026200 8.80e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 7.15e-01 -0.026000 8.55e-01
SHC MEDIATED CASCADE FGFR3 13 8.72e-01 -0.025800 9.39e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 8.68e-01 -0.025700 9.39e-01
P75NTR SIGNALS VIA NF KB 16 8.59e-01 -0.025600 9.36e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 7.65e-01 0.025500 8.87e-01
NGF STIMULATED TRANSCRIPTION 36 7.92e-01 0.025500 9.01e-01
SIGNALING BY ERBB2 IN CANCER 25 8.26e-01 0.025400 9.21e-01
G PROTEIN BETA GAMMA SIGNALLING 31 8.13e-01 0.024600 9.15e-01
IRAK1 RECRUITS IKK COMPLEX 14 8.74e-01 0.024400 9.39e-01
MET ACTIVATES PTK2 SIGNALING 29 8.21e-01 0.024300 9.19e-01
DEGRADATION OF AXIN 53 7.61e-01 0.024200 8.86e-01
MRNA CAPPING 29 8.24e-01 0.023900 9.21e-01
NONHOMOLOGOUS END JOINING NHEJ 46 7.81e-01 -0.023700 8.94e-01
RHO GTPASES ACTIVATE PAKS 21 8.51e-01 -0.023700 9.35e-01
DNA DOUBLE STRAND BREAK REPAIR 140 6.42e-01 -0.022800 8.03e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 5.51e-01 -0.022500 7.35e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 7.78e-01 0.021900 8.94e-01
AGGREPHAGY 34 8.26e-01 0.021900 9.21e-01
INTERLEUKIN 12 FAMILY SIGNALING 43 8.08e-01 0.021400 9.14e-01
ORC1 REMOVAL FROM CHROMATIN 67 7.62e-01 0.021400 8.86e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 7.44e-01 0.021400 8.80e-01
SENSORY PROCESSING OF SOUND 62 7.74e-01 -0.021100 8.92e-01
DEVELOPMENTAL BIOLOGY 831 3.20e-01 -0.020400 5.58e-01
TRANSCRIPTIONAL REGULATION BY MECP2 59 7.91e-01 -0.019900 9.01e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 8.78e-01 0.019900 9.42e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 8.14e-01 0.019800 9.16e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.26e-01 0.019800 9.21e-01
INTERLEUKIN 12 SIGNALING 37 8.36e-01 0.019600 9.27e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 8.80e-01 0.019500 9.43e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 8.36e-01 -0.019400 9.27e-01
DAP12 INTERACTIONS 30 8.55e-01 -0.019300 9.35e-01
REGULATION OF BETA CELL DEVELOPMENT 30 8.56e-01 -0.019100 9.36e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 7.49e-01 -0.018900 8.80e-01
ANTIGEN PROCESSING CROSS PRESENTATION 97 7.48e-01 -0.018900 8.80e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 20 8.86e-01 -0.018600 9.48e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 8.89e-01 -0.018500 9.50e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 7.86e-01 0.018200 8.99e-01
THE NLRP3 INFLAMMASOME 15 9.04e-01 0.018000 9.61e-01
DEGRADATION OF DVL 55 8.20e-01 -0.017700 9.19e-01
SIGNALING BY CSF3 G CSF 29 8.70e-01 0.017500 9.39e-01
FRS MEDIATED FGFR1 SIGNALING 18 8.98e-01 -0.017500 9.56e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 108 7.54e-01 -0.017400 8.84e-01
FLT3 SIGNALING IN DISEASE 28 8.74e-01 0.017300 9.39e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 9.22e-01 -0.017000 9.72e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 68 8.11e-01 -0.016800 9.15e-01
RA BIOSYNTHESIS PATHWAY 13 9.18e-01 -0.016600 9.69e-01
SIGNALING BY ERYTHROPOIETIN 24 8.88e-01 0.016600 9.49e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 8.13e-01 0.016400 9.15e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 9.04e-01 -0.016400 9.61e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 9.25e-01 0.016300 9.74e-01
EXTRACELLULAR MATRIX ORGANIZATION 251 6.63e-01 -0.016000 8.19e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 8.07e-01 0.016000 9.14e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 8.59e-01 -0.015800 9.36e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 8.46e-01 -0.015400 9.31e-01
HIV TRANSCRIPTION INITIATION 45 8.58e-01 0.015400 9.36e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 8.38e-01 0.015000 9.27e-01
TRANSCRIPTIONAL REGULATION BY TP53 343 6.40e-01 0.014700 8.02e-01
SEMAPHORIN INTERACTIONS 64 8.39e-01 -0.014700 9.27e-01
DAP12 SIGNALING 24 9.02e-01 -0.014500 9.60e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 8.66e-01 -0.014400 9.39e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 8.96e-01 0.014300 9.56e-01
G2 M CHECKPOINTS 136 7.75e-01 -0.014200 8.93e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 9.09e-01 -0.014100 9.63e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 9.21e-01 -0.013900 9.72e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 8.66e-01 -0.013600 9.39e-01
SIGNALING BY FGFR 75 8.43e-01 0.013200 9.29e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 9.39e-01 0.012700 9.76e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 9.11e-01 0.012600 9.64e-01
ENDOGENOUS STEROLS 20 9.24e-01 0.012400 9.73e-01
JOSEPHIN DOMAIN DUBS 11 9.46e-01 0.011800 9.76e-01
MAPK6 MAPK4 SIGNALING 83 8.53e-01 -0.011800 9.35e-01
PI 3K CASCADE FGFR4 13 9.42e-01 0.011600 9.76e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 9.48e-01 -0.011400 9.76e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 23 9.27e-01 0.011000 9.74e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 9.08e-01 -0.010900 9.63e-01
DNA REPAIR 295 7.56e-01 -0.010500 8.85e-01
N GLYCAN ANTENNAE ELONGATION 15 9.45e-01 0.010300 9.76e-01
HEME SIGNALING 46 9.06e-01 -0.010100 9.61e-01
SIGNALING BY NOTCH4 83 8.74e-01 0.010100 9.39e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 9.40e-01 0.009930 9.76e-01
ESR MEDIATED SIGNALING 171 8.24e-01 -0.009870 9.21e-01
SIGNALING BY NODAL 15 9.50e-01 0.009360 9.77e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 9.44e-01 0.009260 9.76e-01
NERVOUS SYSTEM DEVELOPMENT 553 7.16e-01 -0.009080 8.55e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 9.43e-01 0.008980 9.76e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 9.42e-01 0.008840 9.76e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 9.35e-01 -0.008720 9.76e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 606 7.19e-01 -0.008580 8.57e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 9.48e-01 0.008570 9.76e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 9.61e-01 -0.008550 9.80e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 29 9.37e-01 -0.008520 9.76e-01
PERK REGULATES GENE EXPRESSION 28 9.39e-01 -0.008380 9.76e-01
FANCONI ANEMIA PATHWAY 36 9.33e-01 0.008140 9.76e-01
CELLULAR SENESCENCE 144 8.68e-01 0.008050 9.39e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 9.30e-01 0.007960 9.76e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 8.97e-01 0.007760 9.56e-01
METALLOPROTEASE DUBS 26 9.48e-01 -0.007340 9.76e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 179 8.67e-01 0.007280 9.39e-01
DNA DAMAGE BYPASS 47 9.31e-01 -0.007270 9.76e-01
STABILIZATION OF P53 54 9.27e-01 -0.007250 9.74e-01
POLO LIKE KINASE MEDIATED EVENTS 14 9.63e-01 -0.007170 9.80e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 9.47e-01 0.007010 9.76e-01
TELOMERE EXTENSION BY TELOMERASE 22 9.55e-01 -0.006880 9.79e-01
SIGNALING BY NOTCH 192 8.73e-01 0.006710 9.39e-01
SURFACTANT METABOLISM 16 9.63e-01 0.006700 9.80e-01
ANTIMICROBIAL PEPTIDES 16 9.64e-01 -0.006450 9.81e-01
MITOCHONDRIAL BIOGENESIS 92 9.16e-01 0.006360 9.69e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 9.56e-01 -0.006320 9.79e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 60 9.42e-01 -0.005470 9.76e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 9.61e-01 -0.005240 9.80e-01
FOXO MEDIATED TRANSCRIPTION 57 9.48e-01 -0.005000 9.76e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 9.67e-01 -0.004980 9.82e-01
SYNDECAN INTERACTIONS 27 9.66e-01 0.004800 9.81e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 9.44e-01 -0.004750 9.76e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 9.53e-01 -0.004660 9.78e-01
SIGNALING BY FGFR2 63 9.49e-01 0.004650 9.76e-01
CELLULAR RESPONSE TO HYPOXIA 72 9.48e-01 -0.004430 9.76e-01
DUAL INCISION IN GG NER 41 9.61e-01 -0.004380 9.80e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 9.68e-01 -0.004330 9.82e-01
NUCLEOTIDE EXCISION REPAIR 110 9.41e-01 0.004070 9.76e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 9.74e-01 0.003990 9.85e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 9.79e-01 0.003970 9.87e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 9.53e-01 -0.003680 9.78e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 9.79e-01 -0.003620 9.87e-01
OTHER INTERLEUKIN SIGNALING 20 9.78e-01 0.003500 9.87e-01
TRANSCRIPTION OF THE HIV GENOME 67 9.61e-01 0.003430 9.80e-01
CHAPERONE MEDIATED AUTOPHAGY 20 9.80e-01 -0.003300 9.87e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 9.86e-01 -0.003100 9.92e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 59 9.69e-01 0.002950 9.82e-01
PEPTIDE LIGAND BINDING RECEPTORS 112 9.61e-01 0.002710 9.80e-01
SIGNALING BY FGFR IN DISEASE 57 9.79e-01 -0.002010 9.87e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 9.91e-01 0.001650 9.95e-01
HATS ACETYLATE HISTONES 96 9.83e-01 0.001290 9.89e-01
SIGNALING BY PDGF 56 9.87e-01 -0.001250 9.92e-01
RNA POLYMERASE II TRANSCRIPTION 1098 9.73e-01 0.000604 9.85e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 9.92e-01 0.000471 9.96e-01
AURKA ACTIVATION BY TPX2 71 9.95e-01 0.000398 9.98e-01
ARACHIDONIC ACID METABOLISM 39 9.97e-01 0.000323 9.99e-01
HS GAG DEGRADATION 20 9.99e-01 -0.000233 9.99e-01
MUSCLE CONTRACTION 160 9.98e-01 -0.000098 9.99e-01


Detailed Gene set reports



CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
154
set CITRIC ACID CYCLE TCA CYCLE
setSize 22
pANOVA 3.44e-05
s.dist 0.51
p.adjustANOVA 0.000941



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fh1 9133
Idh3a 8827
Dld 8678
Suclg2 8614
Aco2 8602
Idh2 8064
Sucla2 7808
Idh3b 7713
Sdha 6929
Dlst 6267
Me2 6249
Cs 5426
Sdhd 5004
Idh3g 5001
Ogdh 4675
Nnt 3267
Mdh2 2250
Sdhb 1649
Sdhc 1351
Suclg1 982

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fh1 9133
Idh3a 8827
Dld 8678
Suclg2 8614
Aco2 8602
Idh2 8064
Sucla2 7808
Idh3b 7713
Sdha 6929
Dlst 6267
Me2 6249
Cs 5426
Sdhd 5004
Idh3g 5001
Ogdh 4675
Nnt 3267
Mdh2 2250
Sdhb 1649
Sdhc 1351
Suclg1 982
Me3 -990
Fahd1 -4036


OLFACTORY SIGNALING PATHWAY

OLFACTORY SIGNALING PATHWAY
663
set OLFACTORY SIGNALING PATHWAY
setSize 37
pANOVA 1.51e-07
s.dist -0.499
p.adjustANOVA 1.11e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Olfr981 -8240
Olfr1310 -8239
Olfr354 -8223
Olfr1192-ps1 -8078
Olfr90 -7978
Olfr635 -7971
Olfr1309 -7846
Olfr986 -7571
Gng13 -7562
Olfr1385 -7541
Olfr804 -7478
Olfr161 -7379
Olfr365 -7362
Olfr558 -7277
Olfr796 -7245
Olfr63 -7101
Olfr1507 -6904
Olfr78 -6875
Olfr1564 -6546
Olfr2 -5832

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Olfr981 -8240
Olfr1310 -8239
Olfr354 -8223
Olfr1192-ps1 -8078
Olfr90 -7978
Olfr635 -7971
Olfr1309 -7846
Olfr986 -7571
Gng13 -7562
Olfr1385 -7541
Olfr804 -7478
Olfr161 -7379
Olfr365 -7362
Olfr558 -7277
Olfr796 -7245
Olfr63 -7101
Olfr1507 -6904
Olfr78 -6875
Olfr1564 -6546
Olfr2 -5832
Olfr735 -5804
Olfr31 -5445
Rtp4 -5038
Olfr147 -3047
Olfr95 -2964
Olfr552 -1382
Olfr137 -1240
Reep4 -272
Reep6 -269
Olfr287 473
Olfr648 1879
Reep2 3136
Gnal 4031
Gnb1 4895
Reep3 5314
Reep5 6599
Reep1 7064


SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
1046
set SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
setSize 11
pANOVA 0.0042
s.dist 0.498
p.adjustANOVA 0.033



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fig4 9255
Pik3c3 6958
Pik3c2a 6871
Pik3r4 6218
Mtmr2 6064
Vac14 5945
Mtm1 5796
Mtmr7 5163
Mtmr4 4824
Mtmr9 -1103
Pikfyve -1363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fig4 9255
Pik3c3 6958
Pik3c2a 6871
Pik3r4 6218
Mtmr2 6064
Vac14 5945
Mtm1 5796
Mtmr7 5163
Mtmr4 4824
Mtmr9 -1103
Pikfyve -1363


ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
47
set ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize 12
pANOVA 0.00304
s.dist 0.494
p.adjustANOVA 0.0258



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsd17b4 8978
Elovl2 8860
Acox1 8768
Fads2 8555
Acsl1 7586
Fads1 7236
Elovl1 6340
Elovl5 6153
Scp2 4295
Acaa1a -518
Acot8 -2870
Abcd1 -4259

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsd17b4 8978
Elovl2 8860
Acox1 8768
Fads2 8555
Acsl1 7586
Fads1 7236
Elovl1 6340
Elovl5 6153
Scp2 4295
Acaa1a -518
Acot8 -2870
Abcd1 -4259


PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
757
set PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
setSize 12
pANOVA 0.00362
s.dist 0.485
p.adjustANOVA 0.0296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6791
Impdh2 6200
Ppat 5022
Impdh1 3875
Gmps 3087
Lhpp 2720
Adssl1 2686
Pfas -4910

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6791
Impdh2 6200
Ppat 5022
Impdh1 3875
Gmps 3087
Lhpp 2720
Adssl1 2686
Pfas -4910


CALNEXIN CALRETICULIN CYCLE

CALNEXIN CALRETICULIN CYCLE
110
set CALNEXIN CALRETICULIN CYCLE
setSize 26
pANOVA 2.35e-05
s.dist 0.479
p.adjustANOVA 0.000768



Top enriched genes

Top 20 genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Pdia3 8431
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6523
Ubc 5932
Edem1 5389
Calr 5198
Sel1l 5080
Rnf103 5033
Trim13 4178
Uggt2 3860
Rnf185 2134

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Pdia3 8431
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6523
Ubc 5932
Edem1 5389
Calr 5198
Sel1l 5080
Rnf103 5033
Trim13 4178
Uggt2 3860
Rnf185 2134
Canx 1752
Rnf5 1025
Prkcsh 96
Rps27a -2071
Ubb -2115
Uba52 -7859


ER QUALITY CONTROL COMPARTMENT ERQC

ER QUALITY CONTROL COMPARTMENT ERQC
293
set ER QUALITY CONTROL COMPARTMENT ERQC
setSize 21
pANOVA 0.000158
s.dist 0.476
p.adjustANOVA 0.00298



Top enriched genes

Top 20 genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Man1b1 8695
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6523
Ubc 5932
Edem1 5389
Sel1l 5080
Rnf103 5033
Trim13 4178
Uggt2 3860
Rnf185 2134
Rnf5 1025
Rps27a -2071
Ubb -2115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Man1b1 8695
Syvn1 8025
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6523
Ubc 5932
Edem1 5389
Sel1l 5080
Rnf103 5033
Trim13 4178
Uggt2 3860
Rnf185 2134
Rnf5 1025
Rps27a -2071
Ubb -2115
Uba52 -7859


RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
860
set RHOBTB3 ATPASE CYCLE
setSize 10
pANOVA 0.00936
s.dist 0.475
p.adjustANOVA 0.0582



Top enriched genes

Top 20 genes
GeneID Gene Rank
Htr7 9100
Cul3 8203
Lrrc41 7885
Plin3 6740
Rhobtb3 6730
Hgs 5861
Rab9b 4398
Vhl 2581
Rab9 -1262
Ccne1 -2675

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Htr7 9100
Cul3 8203
Lrrc41 7885
Plin3 6740
Rhobtb3 6730
Hgs 5861
Rab9b 4398
Vhl 2581
Rab9 -1262
Ccne1 -2675


BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM
104
set BRANCHED CHAIN AMINO ACID CATABOLISM
setSize 21
pANOVA 0.000192
s.dist 0.47
p.adjustANOVA 0.00337



Top enriched genes

Top 20 genes
GeneID Gene Rank
Aldh6a1 9266
Ivd 8736
Dld 8678
Echs1 8363
Acat1 8250
Hibadh 8043
Dbt 7239
Acad8 7102
Slc25a44 6765
Acadsb 6761
Bcat2 6689
Bckdhb 6648
Mccc2 5898
Mccc1 5344
Hsd17b10 3221
Bcat1 2399
Hibch -65
Bckdk -1049
Bckdha -1160
Auh -1850

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aldh6a1 9266
Ivd 8736
Dld 8678
Echs1 8363
Acat1 8250
Hibadh 8043
Dbt 7239
Acad8 7102
Slc25a44 6765
Acadsb 6761
Bcat2 6689
Bckdhb 6648
Mccc2 5898
Mccc1 5344
Hsd17b10 3221
Bcat1 2399
Hibch -65
Bckdk -1049
Bckdha -1160
Auh -1850
Ppm1k -6285


SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
1044
set SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
setSize 16
pANOVA 0.00114
s.dist 0.47
p.adjustANOVA 0.0127



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fig4 9255
Mtmr10 8910
Inpp5f 7618
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6871
Pik3r4 6218
Mtmr2 6064
Vac14 5945
Mtm1 5796
Inpp4b 5661
Mtmr4 4824
Mtmr12 2421
Pikfyve -1363
Pi4k2b -2260
Inpp4a -4795

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fig4 9255
Mtmr10 8910
Inpp5f 7618
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6871
Pik3r4 6218
Mtmr2 6064
Vac14 5945
Mtm1 5796
Inpp4b 5661
Mtmr4 4824
Mtmr12 2421
Pikfyve -1363
Pi4k2b -2260
Inpp4a -4795


INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1

INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
448
set INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
setSize 13
pANOVA 0.00398
s.dist 0.461
p.adjustANOVA 0.0317



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prim2 8549
E2f1 8530
Tfdp1 8407
Prim1 7456
Rb1 7232
Pola2 7148
Pola1 5712
Ppp2ca 5171
Ppp2r1a 4643
Ppp2r1b 3997
Tfdp2 950
Ppp2cb -1872
Ppp2r3d -5628

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prim2 8549
E2f1 8530
Tfdp1 8407
Prim1 7456
Rb1 7232
Pola2 7148
Pola1 5712
Ppp2ca 5171
Ppp2r1a 4643
Ppp2r1b 3997
Tfdp2 950
Ppp2cb -1872
Ppp2r3d -5628


ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
74
set ASPARTATE AND ASPARAGINE METABOLISM
setSize 10
pANOVA 0.0125
s.dist 0.456
p.adjustANOVA 0.0713



Top enriched genes

Top 20 genes
GeneID Gene Rank
Folh1 9329
Asns 7860
Slc25a12 7310
Aspa 6690
Got1 6414
Got2 5975
Slc25a13 2805
Aspg 1022
Nat8l -149
Naalad2 -1305

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Folh1 9329
Asns 7860
Slc25a12 7310
Aspa 6690
Got1 6414
Got2 5975
Slc25a13 2805
Aspg 1022
Nat8l -149
Naalad2 -1305


MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
539
set MET ACTIVATES RAP1 AND RAC1
setSize 10
pANOVA 0.0133
s.dist 0.452
p.adjustANOVA 0.0732



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rac1 8591
Rap1b 7791
Crkl 7397
Crk 6793
Gab1 6014
Rap1a 5148
Met 3935
Rapgef1 3784
Grb2 -1885
Dock7 -1969

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rac1 8591
Rap1b 7791
Crkl 7397
Crk 6793
Gab1 6014
Rap1a 5148
Met 3935
Rapgef1 3784
Grb2 -1885
Dock7 -1969


BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM
92
set BBSOME MEDIATED CARGO TARGETING TO CILIUM
setSize 23
pANOVA 0.000175
s.dist 0.452
p.adjustANOVA 0.00321



Top enriched genes

Top 20 genes
GeneID Gene Rank
Lztfl1 8991
Tcp1 8148
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6618
Bbs7 6425
Cct5 6045
Ttc8 5746
Bbs10 5621
Bbs4 5540
Cct4 5520
Smo 5122
Cct2 3787
Sstr3 3325
Cct8 3153
Bbs2 306
Bbs12 -115

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Lztfl1 8991
Tcp1 8148
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6618
Bbs7 6425
Cct5 6045
Ttc8 5746
Bbs10 5621
Bbs4 5540
Cct4 5520
Smo 5122
Cct2 3787
Sstr3 3325
Cct8 3153
Bbs2 306
Bbs12 -115
Bbs9 -196
Bbip1 -690
Bbs5 -4881


RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
842
set RETROGRADE NEUROTROPHIN SIGNALLING
setSize 14
pANOVA 0.00482
s.dist 0.435
p.adjustANOVA 0.0364



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dnm2 9347
Ap2b1 7444
Ap2a2 7134
Ntrk1 6899
Cltc 6291
Dnm3 6028
Ngf 5435
Dnm1 4326
Ap2m1 4122
Ap2a1 3883
Sh3gl2 3298
Dnal4 1863
Clta -54
Ap2s1 -4313

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dnm2 9347
Ap2b1 7444
Ap2a2 7134
Ntrk1 6899
Cltc 6291
Dnm3 6028
Ngf 5435
Dnm1 4326
Ap2m1 4122
Ap2a1 3883
Sh3gl2 3298
Dnal4 1863
Clta -54
Ap2s1 -4313


CAMK IV MEDIATED PHOSPHORYLATION OF CREB

CAMK IV MEDIATED PHOSPHORYLATION OF CREB
111
set CAMK IV MEDIATED PHOSPHORYLATION OF CREB
setSize 10
pANOVA 0.0187
s.dist 0.429
p.adjustANOVA 0.0896



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kpna2 9344
Creb1 8392
Camk2a 7843
Camkk1 6095
Camk2g 5543
Camk4 5130
Camk2d 3322
Camk2b 943
Camkk2 43
Calm1 -3079

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kpna2 9344
Creb1 8392
Camk2a 7843
Camkk1 6095
Camk2g 5543
Camk4 5130
Camk2d 3322
Camk2b 943
Camkk2 43
Calm1 -3079


SCAVENGING OF HEME FROM PLASMA

SCAVENGING OF HEME FROM PLASMA
907
set SCAVENGING OF HEME FROM PLASMA
setSize 11
pANOVA 0.0144
s.dist -0.426
p.adjustANOVA 0.0761



Top enriched genes

Top 20 genes
GeneID Gene Rank
Apol7e -6909
Hp -6777
Apol9a -6641
Hbb-bt -5506
Hba-a1 -5351
Jchain -5032
Hba-a2 -4252
Apoa1 -2839
Apol8 1404
Lrp1 2282
Cd163 4594

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Apol7e -6909
Hp -6777
Apol9a -6641
Hbb-bt -5506
Hba-a1 -5351
Jchain -5032
Hba-a2 -4252
Apoa1 -2839
Apol8 1404
Lrp1 2282
Cd163 4594


SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
1051
set SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize 20
pANOVA 0.000982
s.dist 0.426
p.adjustANOVA 0.0114



Top enriched genes

Top 20 genes
GeneID Gene Rank
Acsbg1 9232
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6744
Elovl4 6612
Elovl1 6340
Elovl5 6153
Acsf3 4043
Acsl5 3751
Elovl6 3694
Hacd3 1138
Slc27a3 -2394
Tecr -4047
Hacd1 -5403
Elovl7 -5881

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acsbg1 9232
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6744
Elovl4 6612
Elovl1 6340
Elovl5 6153
Acsf3 4043
Acsl5 3751
Elovl6 3694
Hacd3 1138
Slc27a3 -2394
Tecr -4047
Hacd1 -5403
Elovl7 -5881


N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
594
set N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
setSize 35
pANOVA 1.56e-05
s.dist 0.422
p.adjustANOVA 0.000581



Top enriched genes

Top 20 genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Derl1 8460
Pdia3 8431
Mlec 8086
Syvn1 8025
Ngly1 8020
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6523
Ubc 5932
Edem1 5389
Calr 5198
Sel1l 5080
Rnf103 5033

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Edem2 9300
Derl2 9261
Ganab 9006
Man1b1 8695
Derl1 8460
Pdia3 8431
Mlec 8086
Syvn1 8025
Ngly1 8020
Amfr 7876
Uggt1 7856
Os9 7744
Rnf139 7183
Marchf6 7065
Edem3 6523
Ubc 5932
Edem1 5389
Calr 5198
Sel1l 5080
Rnf103 5033
Rad23b 4886
Vcp 4493
Trim13 4178
Uggt2 3860
Rnf185 2134
Canx 1752
Rnf5 1025
Engase 897
Prkcsh 96
Rps27a -2071
Ubb -2115
Ubxn1 -2534
Mogs -2859
Psmc1 -4016
Uba52 -7859


THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS

THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
1073
set THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
setSize 27
pANOVA 0.000188
s.dist 0.415
p.adjustANOVA 0.00335



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ap1m1 9091
Elmo1 8839
Pak2 8711
Fyn 8650
Rac1 8591
Ap1b1 7973
H2-Q2 7969
Atp6v1h 7606
Ap2b1 7444
Ap2a2 7134
Hck 6758
Dock2 6604
Ap1m2 5627
Arf1 4881
Pacs1 4524
Ap2m1 4122
Ap2a1 3883
Ap1g1 3869
Ap1s1 3748
Ap1s2 2197

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ap1m1 9091
Elmo1 8839
Pak2 8711
Fyn 8650
Rac1 8591
Ap1b1 7973
H2-Q2 7969
Atp6v1h 7606
Ap2b1 7444
Ap2a2 7134
Hck 6758
Dock2 6604
Ap1m2 5627
Arf1 4881
Pacs1 4524
Ap2m1 4122
Ap2a1 3883
Ap1g1 3869
Ap1s1 3748
Ap1s2 2197
Lck 1852
H2-Q7 40
B2m -114
H2-D1 -2015
H2-Q10 -2381
Ap2s1 -4313
Ap1s3 -7097


POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION

POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
728
set POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
setSize 26
pANOVA 0.000313
s.dist 0.408
p.adjustANOVA 0.0046



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nup54 8879
Ndc1 8176
Rcc1 7498
Nup160 7385
Tnpo1 7074
Nup107 6351
Nup205 6182
Pom121 5822
Nup133 5734
Nup37 5696
Sec13 5690
Kpnb1 5613
Seh1l 4719
Nup85 4516
Ahctf1 4490
Ube2i 4393
Nup188 3203
Sumo1 2910
Ran 2863
Rangap1 2273

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nup54 8879
Ndc1 8176
Rcc1 7498
Nup160 7385
Tnpo1 7074
Nup107 6351
Nup205 6182
Pom121 5822
Nup133 5734
Nup37 5696
Sec13 5690
Kpnb1 5613
Seh1l 4719
Nup85 4516
Ahctf1 4490
Ube2i 4393
Nup188 3203
Sumo1 2910
Ran 2863
Rangap1 2273
Nup98 2184
Nup35 1611
Nup43 1247
Nup93 -1282
Nup62 -1905
Nup155 -2921


CARNITINE METABOLISM

CARNITINE METABOLISM
117
set CARNITINE METABOLISM
setSize 14
pANOVA 0.00834
s.dist 0.407
p.adjustANOVA 0.0535



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cpt1a 8349
Prkag2 7700
Cpt2 7512
Rxra 7494
Prkaa2 7318
Cpt1b 6931
Mid1ip1 6514
Acacb 4802
Acaca 3651
Ppard 2869
Slc25a20 2357
Thrsp 18
Prkab2 -699
Slc22a5 -6559

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cpt1a 8349
Prkag2 7700
Cpt2 7512
Rxra 7494
Prkaa2 7318
Cpt1b 6931
Mid1ip1 6514
Acacb 4802
Acaca 3651
Ppard 2869
Slc25a20 2357
Thrsp 18
Prkab2 -699
Slc22a5 -6559


ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS

ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
8
set ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
setSize 10
pANOVA 0.026
s.dist 0.407
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6848
Chrna5 6009
Chrnb4 5457
Chrnb2 4195
Chrnb3 2106
Chrna2 1054
Chrna7 1
Chrna1 -542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6848
Chrna5 6009
Chrnb4 5457
Chrnb2 4195
Chrnb3 2106
Chrna2 1054
Chrna7 1
Chrna1 -542


HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS

HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
422
set HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
setSize 10
pANOVA 0.026
s.dist 0.407
p.adjustANOVA 0.111



Top enriched genes

Top 20 genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6848
Chrna5 6009
Chrnb4 5457
Chrnb2 4195
Chrnb3 2106
Chrna2 1054
Chrna7 1
Chrna1 -542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Chrna3 9155
Chrna4 7286
Chrna6 6848
Chrna5 6009
Chrnb4 5457
Chrnb2 4195
Chrnb3 2106
Chrna2 1054
Chrna7 1
Chrna1 -542


PROLONGED ERK ACTIVATION EVENTS

PROLONGED ERK ACTIVATION EVENTS
747
set PROLONGED ERK ACTIVATION EVENTS
setSize 14
pANOVA 0.00938
s.dist 0.401
p.adjustANOVA 0.0582



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mapk1 8052
Map2k1 7865
Crkl 7397
Ntrk1 6899
Crk 6793
Ngf 5435
Mapk3 5188
Rap1a 5148
Frs2 3800
Rapgef1 3784
Ywhab 3617
Braf 1445
Kidins220 -3045
Map2k2 -4884

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk1 8052
Map2k1 7865
Crkl 7397
Ntrk1 6899
Crk 6793
Ngf 5435
Mapk3 5188
Rap1a 5148
Frs2 3800
Rapgef1 3784
Ywhab 3617
Braf 1445
Kidins220 -3045
Map2k2 -4884


SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
1045
set SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
setSize 15
pANOVA 0.00762
s.dist 0.398
p.adjustANOVA 0.0504



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fig4 9255
Sacm1l 7742
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6871
Pik3r4 6218
Ocrl 6104
Vac14 5945
Pi4kb 5175
Arf1 4881
Pi4ka 74
Inpp5e 44
Pikfyve -1363
Arf3 -1726
Pi4k2b -2260

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fig4 9255
Sacm1l 7742
Pi4k2a 7273
Pik3c3 6958
Pik3c2a 6871
Pik3r4 6218
Ocrl 6104
Vac14 5945
Pi4kb 5175
Arf1 4881
Pi4ka 74
Inpp5e 44
Pikfyve -1363
Arf3 -1726
Pi4k2b -2260


FERTILIZATION

FERTILIZATION
321
set FERTILIZATION
setSize 13
pANOVA 0.013
s.dist -0.398
p.adjustANOVA 0.0727



Top enriched genes

Top 20 genes
GeneID Gene Rank
Acr -7105
Ovgp1 -6722
Catsperd -6267
Adam21 -5799
Catsper3 -5156
Catsperg1 -4963
Hvcn1 -3776
B4galt1 -2665
Izumo4 -2140
Catsper2 -1857
Kcnu1 -1465
Cd9 3074
Catsperg2 6686

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acr -7105
Ovgp1 -6722
Catsperd -6267
Adam21 -5799
Catsper3 -5156
Catsperg1 -4963
Hvcn1 -3776
B4galt1 -2665
Izumo4 -2140
Catsper2 -1857
Kcnu1 -1465
Cd9 3074
Catsperg2 6686


GLYCOSPHINGOLIPID METABOLISM

GLYCOSPHINGOLIPID METABOLISM
395
set GLYCOSPHINGOLIPID METABOLISM
setSize 38
pANOVA 2.63e-05
s.dist 0.394
p.adjustANOVA 0.000796



Top enriched genes

Top 20 genes
GeneID Gene Rank
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
B4galnt1 7463
Gba2 7449
Ugt8a 6366
Psap 6328
Ugcg 6318
Gltp 6022
Neu1 5420
Cerk 5234
Neu2 5146
Cptp 5086
Gm2a 5036

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
B4galnt1 7463
Gba2 7449
Ugt8a 6366
Psap 6328
Ugcg 6318
Gltp 6022
Neu1 5420
Cerk 5234
Neu2 5146
Cptp 5086
Gm2a 5036
Hexb 4729
Glb1l 4482
Gba 4021
Arsg 3793
Arsk 3006
Smpd1 2483
Smpd3 2172
Glb1 1254
Esyt2 802
Sumf1 674
Sumf2 -146
Smpd2 -414
Hexa -484
Asah2 -759
Ctsa -3076
Arsj -3299
Smpd4 -3359
Esyt3 -7344


SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI

SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI
1037
set SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI
setSize 18
pANOVA 0.00383
s.dist 0.394
p.adjustANOVA 0.0307



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pigw 9250
Pigf 8812
Pigv 8682
Piga 8636
Pigx 8506
Pigq 6606
Pign 6041
Pigg 5972
Pigc 5803
Pigm 5616
Pigz 4578
Pigo 2824
Pigl 1731
Dpm2 768
Pigh -1609
Pigp -1967
Pigyl -2299
Pigb -5198

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pigw 9250
Pigf 8812
Pigv 8682
Piga 8636
Pigx 8506
Pigq 6606
Pign 6041
Pigg 5972
Pigc 5803
Pigm 5616
Pigz 4578
Pigo 2824
Pigl 1731
Dpm2 768
Pigh -1609
Pigp -1967
Pigyl -2299
Pigb -5198


SPHINGOLIPID METABOLISM

SPHINGOLIPID METABOLISM
1008
set SPHINGOLIPID METABOLISM
setSize 80
pANOVA 1.27e-09
s.dist 0.393
p.adjustANOVA 1.87e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ormdl1 9234
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Sptlc1 8849
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
B4galnt1 7463
Gba2 7449
Degs2 7360
Sptssa 7264

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ormdl1 9234
B3galnt1 9230
Gla 9201
Arsa 8981
Neu3 8944
Galc 8882
Sptlc1 8849
Asah1 8647
Neu4 8522
Esyt1 8442
Arsb 8276
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
B4galnt1 7463
Gba2 7449
Degs2 7360
Sptssa 7264
Osbp 7103
Prkd1 7026
Plpp1 6837
Aldh3a2 6664
Ugt8a 6366
Psap 6328
Ugcg 6318
Prkd3 6316
Sgms2 6026
Cert1 6023
Gltp 6022
Cers5 5942
Cers1 5877
Sgpp1 5776
Csnk1g2 5732
Sgpp2 5582
Neu1 5420
Cerk 5234
Neu2 5146
Sgpl1 5129
Cptp 5086
Gm2a 5036
Ormdl3 4973
Sphk1 4789
Hexb 4729
Sptlc2 4652
Glb1l 4482
Cers6 4399
Sptlc3 4198
Vapb 4056
Gba 4021
Arsg 3793
Ppm1l 3788
Sptssb 3143
Cers2 3111
Arsk 3006
Prkd2 2917
Smpd1 2483
Spns2 2458
Smpd3 2172
Plpp2 1347
Glb1 1254
Esyt2 802
Sumf1 674
Sumf2 -146
Smpd2 -414
Hexa -484
Asah2 -759
Acer2 -1956
Sphk2 -2021
Vapa -2539
Kdsr -2813
Aldh3b1 -2904
Ctsa -3076
Acer3 -3257
Arsj -3299
Smpd4 -3359
Samd8 -5797
Cers4 -7033
Esyt3 -7344


DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS

DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS
221
set DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS
setSize 11
pANOVA 0.0242
s.dist -0.392
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gp1ba -8198
Gp1bb -8001
Ggcx -6806
Tpst1 -5527
Serping1 -5474
Klkb1 -4297
F12 -2627
F8 -2132
Gp5 -310
Vwf 3862
Tpst2 7745

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gp1ba -8198
Gp1bb -8001
Ggcx -6806
Tpst1 -5527
Serping1 -5474
Klkb1 -4297
F12 -2627
F8 -2132
Gp5 -310
Vwf 3862
Tpst2 7745


SPHINGOLIPID DE NOVO BIOSYNTHESIS

SPHINGOLIPID DE NOVO BIOSYNTHESIS
1007
set SPHINGOLIPID DE NOVO BIOSYNTHESIS
setSize 42
pANOVA 1.25e-05
s.dist 0.39
p.adjustANOVA 0.000522



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ormdl1 9234
Sptlc1 8849
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
Degs2 7360
Sptssa 7264
Osbp 7103
Prkd1 7026
Plpp1 6837
Aldh3a2 6664
Prkd3 6316
Sgms2 6026
Cert1 6023
Cers5 5942
Cers1 5877
Sgpp1 5776
Csnk1g2 5732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ormdl1 9234
Sptlc1 8849
Fa2h 8124
Plpp3 7944
Degs1 7942
Ormdl2 7928
Sgms1 7852
Degs2 7360
Sptssa 7264
Osbp 7103
Prkd1 7026
Plpp1 6837
Aldh3a2 6664
Prkd3 6316
Sgms2 6026
Cert1 6023
Cers5 5942
Cers1 5877
Sgpp1 5776
Csnk1g2 5732
Sgpp2 5582
Sgpl1 5129
Ormdl3 4973
Sphk1 4789
Sptlc2 4652
Cers6 4399
Sptlc3 4198
Vapb 4056
Ppm1l 3788
Sptssb 3143
Cers2 3111
Prkd2 2917
Spns2 2458
Plpp2 1347
Acer2 -1956
Sphk2 -2021
Vapa -2539
Kdsr -2813
Aldh3b1 -2904
Acer3 -3257
Samd8 -5797
Cers4 -7033


NUCLEOBASE BIOSYNTHESIS

NUCLEOBASE BIOSYNTHESIS
654
set NUCLEOBASE BIOSYNTHESIS
setSize 15
pANOVA 0.01
s.dist 0.384
p.adjustANOVA 0.061



Top enriched genes

Top 20 genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6791
Impdh2 6200
Ppat 5022
Umps 4176
Impdh1 3875
Gmps 3087
Lhpp 2720
Adssl1 2686
Dhodh 140
Cad -3152
Pfas -4910

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Paics 9163
Atic 7987
Adsl 7826
Gart 7723
Adss 6791
Impdh2 6200
Ppat 5022
Umps 4176
Impdh1 3875
Gmps 3087
Lhpp 2720
Adssl1 2686
Dhodh 140
Cad -3152
Pfas -4910


COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN
164
set COHESIN LOADING ONTO CHROMATIN
setSize 10
pANOVA 0.0374
s.dist 0.38
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rad21 8790
Stag2 8475
Pds5b 8032
Stag1 7069
Mau2 3628
Smc1a 3616
Pds5a 3446
Wapl 1482
Nipbl 1043
Smc3 -6346

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rad21 8790
Stag2 8475
Pds5b 8032
Stag1 7069
Mau2 3628
Smc1a 3616
Pds5a 3446
Wapl 1482
Nipbl 1043
Smc3 -6346


CTLA4 INHIBITORY SIGNALING

CTLA4 INHIBITORY SIGNALING
193
set CTLA4 INHIBITORY SIGNALING
setSize 20
pANOVA 0.00362
s.dist 0.376
p.adjustANOVA 0.0296



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn11 9296
Yes1 8654
Fyn 8650
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6724
Akt1 6662
Src 5680
Ppp2ca 5171
Ppp2r1a 4643
Akt3 4257
Ppp2r1b 3997
Lck 1852
Ppp2r5a 972
Cd86 361
Akt2 -508
Ppp2cb -1872
Lyn -2069
Cd80 -7687

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9296
Yes1 8654
Fyn 8650
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6724
Akt1 6662
Src 5680
Ppp2ca 5171
Ppp2r1a 4643
Akt3 4257
Ppp2r1b 3997
Lck 1852
Ppp2r5a 972
Cd86 361
Akt2 -508
Ppp2cb -1872
Lyn -2069
Cd80 -7687


ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY
37
set ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize 13
pANOVA 0.0198
s.dist 0.373
p.adjustANOVA 0.0944



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gnai1 8119
Adcy8 7381
Gnai2 6928
Gnai3 6827
Adcy3 5592
Adcy5 5062
Gnal 4031
Adcy1 3295
Adcy2 3030
Adcy9 1919
Adcy7 1718
Adcy4 -1197
Adcy6 -2493

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gnai1 8119
Adcy8 7381
Gnai2 6928
Gnai3 6827
Adcy3 5592
Adcy5 5062
Gnal 4031
Adcy1 3295
Adcy2 3030
Adcy9 1919
Adcy7 1718
Adcy4 -1197
Adcy6 -2493


PROCESSIVE SYNTHESIS ON THE LAGGING STRAND

PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
744
set PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
setSize 15
pANOVA 0.0124
s.dist 0.373
p.adjustANOVA 0.071



Top enriched genes

Top 20 genes
GeneID Gene Rank
Prim2 8549
Prim1 7456
Fen1 7372
Pola2 7148
Pcna 7097
Rpa1 6737
Pola1 5712
Pold2 2951
Pold3 2918
Rpa2 2323
Rpa3 2109
Pold1 1587
Dna2 1476
Pold4 -1605
Lig1 -3924

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Prim2 8549
Prim1 7456
Fen1 7372
Pola2 7148
Pcna 7097
Rpa1 6737
Pola1 5712
Pold2 2951
Pold3 2918
Rpa2 2323
Rpa3 2109
Pold1 1587
Dna2 1476
Pold4 -1605
Lig1 -3924


RHOV GTPASE CYCLE

RHOV GTPASE CYCLE
869
set RHOV GTPASE CYCLE
setSize 33
pANOVA 0.000241
s.dist 0.369
p.adjustANOVA 0.00389



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tpm4 9047
Git1 8959
Nck1 8828
Pak2 8711
Sh3rf1 7833
Wdr6 7605
Peak1 7447
Pak1 7413
Depdc1b 6978
Arhgap12 6937
Sptan1 6656
Cltc 6291
Wasl 6063
Sptbn1 5623
Txnl1 5486
Pik3r1 5024
Usp9x 4932
Epha2 4386
Arhgef7 4333
Cdc42 4309

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tpm4 9047
Git1 8959
Nck1 8828
Pak2 8711
Sh3rf1 7833
Wdr6 7605
Peak1 7447
Pak1 7413
Depdc1b 6978
Arhgap12 6937
Sptan1 6656
Cltc 6291
Wasl 6063
Sptbn1 5623
Txnl1 5486
Pik3r1 5024
Usp9x 4932
Epha2 4386
Arhgef7 4333
Cdc42 4309
Pak6 4038
Dlg5 2786
Tpm3 2377
Vangl1 1703
Rhov 543
Iqgap1 25
Ccp110 -28
Myo9a -37
Dst -927
Nck2 -2459
Git2 -3117
Zfp512b -5052
Cep97 -6532


PLATELET SENSITIZATION BY LDL

PLATELET SENSITIZATION BY LDL
720
set PLATELET SENSITIZATION BY LDL
setSize 15
pANOVA 0.0138
s.dist 0.367
p.adjustANOVA 0.0745



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn11 9296
Pla2g4a 8646
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6724
Ppp2ca 5171
Ppp2r1a 4643
Ppp2r1b 3997
Mapk14 1963
Ppp2r5a 972
Lrp8 629
Ptpn6 -278
Ppp2cb -1872
Pecam1 -5637

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9296
Pla2g4a 8646
Ppp2r5d 8038
Ppp2r5c 7442
Ppp2r5e 7405
Ppp2r5b 6724
Ppp2ca 5171
Ppp2r1a 4643
Ppp2r1b 3997
Mapk14 1963
Ppp2r5a 972
Lrp8 629
Ptpn6 -278
Ppp2cb -1872
Pecam1 -5637


INSULIN PROCESSING

INSULIN PROCESSING
456
set INSULIN PROCESSING
setSize 24
pANOVA 0.00196
s.dist 0.365
p.adjustANOVA 0.0188



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pcsk1 9031
Myrip 8778
Exoc5 8427
Ero1a 8332
Exoc7 8318
Exoc3 8205
Slc30a7 6963
Slc30a5 6863
Pcsk2 6800
Cpe 6309
Myo5a 5840
Kif5a 5703
Exoc1 4048
Kif5c 3833
Exoc4 2467
Exoc2 1208
Exoc8 1072
Ero1b 927
Exoc6 86
Rab27a -33

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pcsk1 9031
Myrip 8778
Exoc5 8427
Ero1a 8332
Exoc7 8318
Exoc3 8205
Slc30a7 6963
Slc30a5 6863
Pcsk2 6800
Cpe 6309
Myo5a 5840
Kif5a 5703
Exoc1 4048
Kif5c 3833
Exoc4 2467
Exoc2 1208
Exoc8 1072
Ero1b 927
Exoc6 86
Rab27a -33
Slc30a6 -372
Kif5b -2113
Stx1a -4257
Vamp2 -5509


LDL CLEARANCE

LDL CLEARANCE
516
set LDL CLEARANCE
setSize 16
pANOVA 0.0115
s.dist 0.365
p.adjustANOVA 0.0671



Top enriched genes

Top 20 genes
GeneID Gene Rank
Soat1 8895
Lipa 7988
Nceh1 7697
Ap2b1 7444
Ap2a2 7134
Npc1 6395
Cltc 6291
Ldlrap1 4884
Ap2m1 4122
Ap2a1 3883
Lsr 3285
Clta -54
Npc2 -185
Ldlr -1174
Pcsk9 -1699
Ap2s1 -4313

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Soat1 8895
Lipa 7988
Nceh1 7697
Ap2b1 7444
Ap2a2 7134
Npc1 6395
Cltc 6291
Ldlrap1 4884
Ap2m1 4122
Ap2a1 3883
Lsr 3285
Clta -54
Npc2 -185
Ldlr -1174
Pcsk9 -1699
Ap2s1 -4313


FATTY ACYL COA BIOSYNTHESIS

FATTY ACYL COA BIOSYNTHESIS
314
set FATTY ACYL COA BIOSYNTHESIS
setSize 32
pANOVA 0.000406
s.dist 0.361
p.adjustANOVA 0.00569



Top enriched genes

Top 20 genes
GeneID Gene Rank
Acsbg1 9232
Ppt1 9171
Rpp14 9016
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6744
Elovl4 6612
Elovl1 6340
Elovl5 6153
Cbr4 6113
Scd2 4934
Acly 4805
Fasn 4777
Scd1 4689
Acsf3 4043

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acsbg1 9232
Ppt1 9171
Rpp14 9016
Acsl3 8989
Elovl2 8860
Acsl6 8499
Hsd17b12 7925
Acsl1 7586
Acsl4 7378
Hacd2 7234
Hacd4 6744
Elovl4 6612
Elovl1 6340
Elovl5 6153
Cbr4 6113
Scd2 4934
Acly 4805
Fasn 4777
Scd1 4689
Acsf3 4043
Acsl5 3751
Elovl6 3694
Acaca 3651
Hacd3 1138
Slc25a1 -653
Ppt2 -1275
Slc27a3 -2394
Tecr -4047
Morc2a -4952
Hacd1 -5403
Elovl7 -5881
H2-Ke6 -6646


SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
1049
set SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
setSize 10
pANOVA 0.0493
s.dist 0.359
p.adjustANOVA 0.173



Top enriched genes

Top 20 genes
GeneID Gene Rank
Itpk1 9115
Nudt4 6774
Ppip5k2 6500
Ip6k1 6235
Ip6k3 5549
Ppip5k1 4291
Nudt11 4005
Nudt3 91
Ippk -2232
Nudt10 -2948

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Itpk1 9115
Nudt4 6774
Ppip5k2 6500
Ip6k1 6235
Ip6k3 5549
Ppip5k1 4291
Nudt11 4005
Nudt3 91
Ippk -2232
Nudt10 -2948


RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY
777
set RECEPTOR MEDIATED MITOPHAGY
setSize 11
pANOVA 0.0406
s.dist 0.357
p.adjustANOVA 0.152



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fundc1 8456
Atg5 7623
Atg12 7486
Pgam5 7265
Src 5680
Csnk2b 3202
Map1lc3b 2839
Ulk1 2740
Csnk2a1 -320
Csnk2a2 -490
Map1lc3a -3610

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fundc1 8456
Atg5 7623
Atg12 7486
Pgam5 7265
Src 5680
Csnk2b 3202
Map1lc3b 2839
Ulk1 2740
Csnk2a1 -320
Csnk2a2 -490
Map1lc3a -3610


REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
814
set REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize 15
pANOVA 0.017
s.dist 0.356
p.adjustANOVA 0.0853



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dld 8678
Pdk3 8528
Pdha1 8186
Pdp1 8170
Rxra 7494
Pdhx 6298
Pdk2 6007
Pdhb 5209
Pdpr 4573
Ppard 2869
Pdk4 2120
Dlat -619
Gstz1 -3089
Pdk1 -4308
Pdp2 -4491

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dld 8678
Pdk3 8528
Pdha1 8186
Pdp1 8170
Rxra 7494
Pdhx 6298
Pdk2 6007
Pdhb 5209
Pdpr 4573
Ppard 2869
Pdk4 2120
Dlat -619
Gstz1 -3089
Pdk1 -4308
Pdp2 -4491


INTRA GOLGI TRAFFIC

INTRA GOLGI TRAFFIC
486
set INTRA GOLGI TRAFFIC
setSize 43
pANOVA 6.28e-05
s.dist 0.353
p.adjustANOVA 0.00145



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cog6 8754
Stx6 8556
Cux1 8537
Man1a 8443
Rab6a 8292
Cog1 7895
Snap29 7684
Cog4 7680
Vps45 7604
Vti1a 7461
Man2a1 6911
Cog2 6693
Napb 6585
Nsf 6550
Napa 6289
Napg 6084
Man1a2 5666
Ric1 5576
Rab30 5442
Golim4 5329

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cog6 8754
Stx6 8556
Cux1 8537
Man1a 8443
Rab6a 8292
Cog1 7895
Snap29 7684
Cog4 7680
Vps45 7604
Vti1a 7461
Man2a1 6911
Cog2 6693
Napb 6585
Nsf 6550
Napa 6289
Napg 6084
Man1a2 5666
Ric1 5576
Rab30 5442
Golim4 5329
Arf1 4881
Golga5 4558
Cog5 4246
Cyth3 4231
Cog3 3938
Gosr2 3125
Rab33b 2428
Stx5a 2302
Ykt6 2265
Man2a2 2234
Gosr1 2163
Rgp1 1998
Cog8 1608
Trip11 1607
Rab39 1406
Cyth1 447
Man1c1 264
Cog7 -2694
Stx16 -3185
Cyth2 -3562
Rab36 -4132
Bet1l -6282
Cyth4 -7803


RHOF GTPASE CYCLE

RHOF GTPASE CYCLE
863
set RHOF GTPASE CYCLE
setSize 41
pANOVA 9.74e-05
s.dist 0.352
p.adjustANOVA 0.00205



Top enriched genes

Top 20 genes
GeneID Gene Rank
Farp1 9236
Snap23 9078
Tor1aip1 9062
Baiap2l1 8815
Esyt1 8442
Rhof 8157
Add3 8016
Sowahc 7962
Diaph1 7686
Cav1 7322
Depdc1b 6978
Arhgap32 6944
Arhgap12 6937
Tmpo 6444
Arhgap21 5835
Steap3 5651
Pik3r1 5024
Arhgap1 4996
Arhgap39 4865
Pik3r2 4622

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Farp1 9236
Snap23 9078
Tor1aip1 9062
Baiap2l1 8815
Esyt1 8442
Rhof 8157
Add3 8016
Sowahc 7962
Diaph1 7686
Cav1 7322
Depdc1b 6978
Arhgap32 6944
Arhgap12 6937
Tmpo 6444
Arhgap21 5835
Steap3 5651
Pik3r1 5024
Arhgap1 4996
Arhgap39 4865
Pik3r2 4622
Mtmr1 4448
Arhgap5 3725
Lmnb1 3654
Fam169a 3591
Akap12 3187
Diaph2 2912
Capzb 2842
Diaph3 1929
Vangl1 1703
Rab7 1273
Actn1 1213
Srgap2 1106
Syde1 -22
Basp1 -724
Slc4a7 -912
Mcam -1153
Baiap2l2 -2596
Myo9b -3015
Vamp3 -3112
Senp1 -3882
Actb -7868


PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES

PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
755
set PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
setSize 14
pANOVA 0.0238
s.dist 0.349
p.adjustANOVA 0.107



Top enriched genes

Top 20 genes
GeneID Gene Rank
Elmo1 8839
Rac1 8591
Rasa1 8289
Crk 6793
Arhgap35 6277
Ptk6 5618
Bcar1 4183
Kras 3745
Elmo2 3368
Dock1 2201
Rhoa 2051
Pxn -949
Hras -3603
Nras -4341

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Elmo1 8839
Rac1 8591
Rasa1 8289
Crk 6793
Arhgap35 6277
Ptk6 5618
Bcar1 4183
Kras 3745
Elmo2 3368
Dock1 2201
Rhoa 2051
Pxn -949
Hras -3603
Nras -4341


NUCLEOTIDE LIKE PURINERGIC RECEPTORS

NUCLEOTIDE LIKE PURINERGIC RECEPTORS
658
set NUCLEOTIDE LIKE PURINERGIC RECEPTORS
setSize 13
pANOVA 0.0301
s.dist 0.347
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gpr17 9197
P2ry1 9156
Adora1 8007
P2ry13 7043
Adora2a 5291
Lpar4 4674
Adora2b 3472
P2ry12 2821
P2ry6 2631
P2ry14 68
Lpar6 33
Adora3 -1046
P2ry2 -4090

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpr17 9197
P2ry1 9156
Adora1 8007
P2ry13 7043
Adora2a 5291
Lpar4 4674
Adora2b 3472
P2ry12 2821
P2ry6 2631
P2ry14 68
Lpar6 33
Adora3 -1046
P2ry2 -4090


CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE

CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
116
set CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
setSize 49
pANOVA 2.94e-05
s.dist 0.345
p.adjustANOVA 0.000865



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rp2 9161
Lztfl1 8991
Exoc5 8427
Exoc7 8318
Exoc3 8205
Tcp1 8148
Unc119b 8116
Arf4 7436
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6618
Bbs7 6425
Rab11fip3 6241
Pde6d 6158
Cct5 6045
Gbf1 5754
Ttc8 5746

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rp2 9161
Lztfl1 8991
Exoc5 8427
Exoc7 8318
Exoc3 8205
Tcp1 8148
Unc119b 8116
Arf4 7436
Mchr1 7425
Arl6 7411
Mkks 7250
Bbs1 7110
Rab3ip 7096
Cct3 6618
Bbs7 6425
Rab11fip3 6241
Pde6d 6158
Cct5 6045
Gbf1 5754
Ttc8 5746
Bbs10 5621
Bbs4 5540
Cct4 5520
Smo 5122
Cys1 4281
Rab11a 4161
Exoc1 4048
Cct2 3787
Sstr3 3325
Cct8 3153
Rab8a 2930
Arl13b 2806
Exoc4 2467
Exoc2 1208
Exoc8 1072
Bbs2 306
Exoc6 86
Inpp5e 44
Asap1 21
Bbs12 -115
Pkd2 -195
Bbs9 -196
Bbip1 -690
Cnga4 -1815
Arl3 -2282
Pkd1 -2879
Nphp3 -3678
Bbs5 -4881
Cngb1 -8095


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report