date generated: 2023-08-30

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

The profiling data being passed to mitch
LPS OVA
0610009B22Rik -2.3583781 -1.1332185
0610009E02Rik -0.4921631 -0.3290659
0610009L18Rik -1.5061599 0.1306738
0610010K14Rik -0.7608005 -0.3126674
0610012G03Rik -0.6314820 -0.2034285
0610030E20Rik 1.2199694 -0.5747514

Here are some metrics about the input data profile:

Profiling data metrics
Profile metrics
num_genes_in_profile 17243
duplicated_genes_present 0
num_profile_genes_in_sets 8411
num_profile_genes_not_in_sets 8832
profile_pearson_correl 0.75041
profile_spearman_correl 0.73456

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used:

GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene set metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 428
num_genesets_included 1176

Gene sets by quadrant


Number of significant gene sets (FDR<0.05)= 285

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results


A plot of effect size versus significance


Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

## Warning in kable_styling(., "hover", full_width = FALSE): Please specify format
## in kable. kableExtra can customize either HTML or LaTeX outputs. See
## https://haozhu233.github.io/kableExtra/ for details.
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 6.93e-04 5.61e-03 0.892 -0.692 -0.56300 1.51e-04 2.05e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 8.89e-04 6.61e-03 0.839 0.684 0.48600 1.79e-04 7.77e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.42e-05 5.43e-04 0.833 0.564 0.61200 5.62e-05 1.23e-05
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.06e-03 3.66e-02 0.711 -0.515 -0.49000 3.10e-03 4.90e-03
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.36e-02 5.44e-02 0.669 0.452 0.49300 9.41e-03 4.62e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 2.63e-05 4.61e-04 0.643 -0.480 -0.42800 7.69e-06 6.59e-05
INTERACTION BETWEEN L1 AND ANKYRINS 27 2.15e-05 3.88e-04 0.632 0.515 0.36600 3.59e-06 9.86e-04
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.35e-03 9.32e-03 0.617 0.426 0.44700 9.78e-04 5.37e-04
P75NTR REGULATES AXONOGENESIS 10 3.97e-02 1.25e-01 0.610 -0.439 -0.42400 1.62e-02 2.02e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.81e-04 2.85e-03 0.592 0.381 0.45200 7.68e-04 6.51e-05
MITOCHONDRIAL TRANSLATION 93 9.54e-13 2.24e-10 0.586 -0.400 -0.42800 2.52e-11 9.76e-13
LGI ADAM INTERACTIONS 14 1.05e-02 4.46e-02 0.583 0.466 0.35000 2.54e-03 2.32e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 2.30e-04 2.48e-03 0.572 0.361 0.44400 9.48e-04 4.78e-05
CRISTAE FORMATION 31 1.75e-04 2.00e-03 0.568 -0.397 -0.40600 1.30e-04 8.97e-05
SIGNALING BY LEPTIN 10 6.15e-02 1.69e-01 0.568 0.401 0.40200 2.80e-02 2.78e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 5.97e-03 2.93e-02 0.558 -0.392 -0.39800 3.13e-03 2.66e-03
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 2.72e-03 1.65e-02 0.554 -0.444 -0.33200 5.89e-04 1.02e-02
RUNX3 REGULATES NOTCH SIGNALING 13 1.84e-02 7.04e-02 0.552 0.316 0.45200 4.85e-02 4.75e-03
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 6.86e-04 5.60e-03 0.544 0.262 0.47600 4.22e-02 2.29e-04
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 5.87e-03 2.90e-02 0.543 0.205 0.50300 2.38e-01 3.86e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 3.82e-02 1.22e-01 0.543 0.444 0.31200 1.07e-02 7.35e-02
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 5.69e-02 1.60e-01 0.542 0.319 0.43700 8.03e-02 1.66e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.37e-03 9.33e-03 0.541 -0.393 -0.37100 5.26e-04 1.04e-03
RESPIRATORY ELECTRON TRANSPORT 102 8.30e-12 9.77e-10 0.539 -0.384 -0.37800 2.12e-11 3.99e-11
RORA ACTIVATES GENE EXPRESSION 18 8.98e-03 3.93e-02 0.534 0.416 0.33600 2.27e-03 1.37e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.20e-02 4.97e-02 0.531 -0.362 -0.38900 7.88e-03 4.29e-03
ENDOSOMAL VACUOLAR PATHWAY 10 8.04e-04 6.10e-03 0.529 -0.523 -0.07970 4.17e-03 6.62e-01
INTERLEUKIN 6 SIGNALING 10 8.60e-02 2.08e-01 0.529 0.353 0.39300 5.32e-02 3.13e-02
PENTOSE PHOSPHATE PATHWAY 13 4.25e-02 1.31e-01 0.525 -0.393 -0.34900 1.42e-02 2.94e-02
E2F MEDIATED REGULATION OF DNA REPLICATION 20 8.88e-03 3.90e-02 0.521 -0.357 -0.38000 5.72e-03 3.25e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 7.53e-02 1.91e-01 0.521 -0.358 -0.37800 3.98e-02 3.00e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 4.73e-02 1.42e-01 0.519 0.382 0.35100 1.71e-02 2.85e-02
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 1.04e-04 1.26e-03 0.517 0.331 0.39700 4.23e-04 2.24e-05
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.71e-04 4.10e-03 0.516 0.333 0.39500 1.11e-03 1.11e-04
COMPLEX I BIOGENESIS 56 3.00e-06 6.66e-05 0.513 -0.361 -0.36500 3.04e-06 2.32e-06
ACTIVATION OF SMO 16 2.63e-02 9.15e-02 0.513 0.358 0.36700 1.32e-02 1.09e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 7.92e-03 3.62e-02 0.504 0.389 0.32100 2.05e-03 1.09e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.45e-12 2.44e-10 0.504 -0.353 -0.35900 9.86e-12 3.97e-12
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.06e-03 7.66e-03 0.500 -0.376 -0.32900 2.91e-04 1.51e-03
MITOCHONDRIAL PROTEIN IMPORT 63 1.38e-06 3.30e-05 0.498 -0.347 -0.35700 1.88e-06 9.49e-07
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 3.41e-07 9.78e-06 0.495 -0.391 -0.30400 5.16e-08 2.20e-05
ORC1 REMOVAL FROM CHROMATIN 68 4.81e-07 1.26e-05 0.493 -0.370 -0.32600 1.35e-07 3.41e-06
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 6.28e-09 2.64e-07 0.493 -0.376 -0.31800 1.33e-09 2.86e-07
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 5.12e-02 1.49e-01 0.491 -0.405 -0.27800 1.50e-02 9.59e-02
METABOLISM OF POLYAMINES 58 1.56e-06 3.53e-05 0.489 -0.393 -0.29200 2.33e-07 1.22e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 4.01e-06 8.58e-05 0.488 -0.392 -0.29100 6.20e-07 2.17e-04
RECEPTOR MEDIATED MITOPHAGY 11 6.94e-02 1.81e-01 0.486 -0.401 -0.27400 2.13e-02 1.16e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 2.82e-05 4.81e-04 0.485 -0.386 -0.29500 4.82e-06 4.67e-04
RETINOID CYCLE DISEASE EVENTS 10 4.57e-04 4.01e-03 0.485 -0.485 0.00193 7.98e-03 9.92e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 1.10e-01 2.44e-01 0.484 -0.295 -0.38300 1.06e-01 3.59e-02


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pMANOVA p.adjustMANOVA s.dist s.LPS s.OVA p.LPS p.OVA
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 6.93e-04 5.61e-03 0.89200 -0.692000 -0.563000 1.51e-04 2.05e-03
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 8.89e-04 6.61e-03 0.83900 0.684000 0.486000 1.79e-04 7.77e-03
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.42e-05 5.43e-04 0.83300 0.564000 0.612000 5.62e-05 1.23e-05
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 8.06e-03 3.66e-02 0.71100 -0.515000 -0.490000 3.10e-03 4.90e-03
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 11 1.36e-02 5.44e-02 0.66900 0.452000 0.493000 9.41e-03 4.62e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 2.63e-05 4.61e-04 0.64300 -0.480000 -0.428000 7.69e-06 6.59e-05
INTERACTION BETWEEN L1 AND ANKYRINS 27 2.15e-05 3.88e-04 0.63200 0.515000 0.366000 3.59e-06 9.86e-04
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.35e-03 9.32e-03 0.61700 0.426000 0.447000 9.78e-04 5.37e-04
P75NTR REGULATES AXONOGENESIS 10 3.97e-02 1.25e-01 0.61000 -0.439000 -0.424000 1.62e-02 2.02e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 2.81e-04 2.85e-03 0.59200 0.381000 0.452000 7.68e-04 6.51e-05
MITOCHONDRIAL TRANSLATION 93 9.54e-13 2.24e-10 0.58600 -0.400000 -0.428000 2.52e-11 9.76e-13
LGI ADAM INTERACTIONS 14 1.05e-02 4.46e-02 0.58300 0.466000 0.350000 2.54e-03 2.32e-02
NOTCH HLH TRANSCRIPTION PATHWAY 28 2.30e-04 2.48e-03 0.57200 0.361000 0.444000 9.48e-04 4.78e-05
CRISTAE FORMATION 31 1.75e-04 2.00e-03 0.56800 -0.397000 -0.406000 1.30e-04 8.97e-05
SIGNALING BY LEPTIN 10 6.15e-02 1.69e-01 0.56800 0.401000 0.402000 2.80e-02 2.78e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 5.97e-03 2.93e-02 0.55800 -0.392000 -0.398000 3.13e-03 2.66e-03
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 2.72e-03 1.65e-02 0.55400 -0.444000 -0.332000 5.89e-04 1.02e-02
RUNX3 REGULATES NOTCH SIGNALING 13 1.84e-02 7.04e-02 0.55200 0.316000 0.452000 4.85e-02 4.75e-03
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 6.86e-04 5.60e-03 0.54400 0.262000 0.476000 4.22e-02 2.29e-04
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 5.87e-03 2.90e-02 0.54300 0.205000 0.503000 2.38e-01 3.86e-03
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 3.82e-02 1.22e-01 0.54300 0.444000 0.312000 1.07e-02 7.35e-02
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 5.69e-02 1.60e-01 0.54200 0.319000 0.437000 8.03e-02 1.66e-02
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.37e-03 9.33e-03 0.54100 -0.393000 -0.371000 5.26e-04 1.04e-03
RESPIRATORY ELECTRON TRANSPORT 102 8.30e-12 9.77e-10 0.53900 -0.384000 -0.378000 2.12e-11 3.99e-11
RORA ACTIVATES GENE EXPRESSION 18 8.98e-03 3.93e-02 0.53400 0.416000 0.336000 2.27e-03 1.37e-02
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 1.20e-02 4.97e-02 0.53100 -0.362000 -0.389000 7.88e-03 4.29e-03
ENDOSOMAL VACUOLAR PATHWAY 10 8.04e-04 6.10e-03 0.52900 -0.523000 -0.079700 4.17e-03 6.62e-01
INTERLEUKIN 6 SIGNALING 10 8.60e-02 2.08e-01 0.52900 0.353000 0.393000 5.32e-02 3.13e-02
PENTOSE PHOSPHATE PATHWAY 13 4.25e-02 1.31e-01 0.52500 -0.393000 -0.349000 1.42e-02 2.94e-02
E2F MEDIATED REGULATION OF DNA REPLICATION 20 8.88e-03 3.90e-02 0.52100 -0.357000 -0.380000 5.72e-03 3.25e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 7.53e-02 1.91e-01 0.52100 -0.358000 -0.378000 3.98e-02 3.00e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 4.73e-02 1.42e-01 0.51900 0.382000 0.351000 1.71e-02 2.85e-02
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 1.04e-04 1.26e-03 0.51700 0.331000 0.397000 4.23e-04 2.24e-05
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 4.71e-04 4.10e-03 0.51600 0.333000 0.395000 1.11e-03 1.11e-04
COMPLEX I BIOGENESIS 56 3.00e-06 6.66e-05 0.51300 -0.361000 -0.365000 3.04e-06 2.32e-06
ACTIVATION OF SMO 16 2.63e-02 9.15e-02 0.51300 0.358000 0.367000 1.32e-02 1.09e-02
SYNAPTIC ADHESION LIKE MOLECULES 21 7.92e-03 3.62e-02 0.50400 0.389000 0.321000 2.05e-03 1.09e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.45e-12 2.44e-10 0.50400 -0.353000 -0.359000 9.86e-12 3.97e-12
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.06e-03 7.66e-03 0.50000 -0.376000 -0.329000 2.91e-04 1.51e-03
MITOCHONDRIAL PROTEIN IMPORT 63 1.38e-06 3.30e-05 0.49800 -0.347000 -0.357000 1.88e-06 9.49e-07
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 3.41e-07 9.78e-06 0.49500 -0.391000 -0.304000 5.16e-08 2.20e-05
ORC1 REMOVAL FROM CHROMATIN 68 4.81e-07 1.26e-05 0.49300 -0.370000 -0.326000 1.35e-07 3.41e-06
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 6.28e-09 2.64e-07 0.49300 -0.376000 -0.318000 1.33e-09 2.86e-07
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 5.12e-02 1.49e-01 0.49100 -0.405000 -0.278000 1.50e-02 9.59e-02
METABOLISM OF POLYAMINES 58 1.56e-06 3.53e-05 0.48900 -0.393000 -0.292000 2.33e-07 1.22e-04
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 4.01e-06 8.58e-05 0.48800 -0.392000 -0.291000 6.20e-07 2.17e-04
RECEPTOR MEDIATED MITOPHAGY 11 6.94e-02 1.81e-01 0.48600 -0.401000 -0.274000 2.13e-02 1.16e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 47 2.82e-05 4.81e-04 0.48500 -0.386000 -0.295000 4.82e-06 4.67e-04
RETINOID CYCLE DISEASE EVENTS 10 4.57e-04 4.01e-03 0.48500 -0.485000 0.001930 7.98e-03 9.92e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 1.10e-01 2.44e-01 0.48400 -0.295000 -0.383000 1.06e-01 3.59e-02
PHASE 2 PLATEAU PHASE 12 7.29e-02 1.87e-01 0.48100 0.293000 0.381000 7.92e-02 2.23e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 2.04e-02 7.50e-02 0.47900 0.250000 0.409000 9.43e-02 6.07e-03
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 4.69e-03 2.53e-02 0.47600 0.318000 0.354000 4.26e-03 1.45e-03
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 5.86e-03 2.90e-02 0.47600 0.367000 0.302000 1.47e-03 8.94e-03
CD28 DEPENDENT VAV1 PATHWAY 11 5.64e-02 1.59e-01 0.47500 -0.409000 -0.243000 1.89e-02 1.64e-01
TIGHT JUNCTION INTERACTIONS 17 2.03e-02 7.49e-02 0.47500 -0.390000 -0.271000 5.32e-03 5.32e-02
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 4.35e-02 1.34e-01 0.47200 0.314000 0.352000 2.97e-02 1.47e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 6.40e-06 1.30e-04 0.47000 -0.366000 -0.294000 1.14e-06 9.32e-05
PHOSPHORYLATION OF THE APC C 18 2.01e-02 7.48e-02 0.47000 -0.380000 -0.276000 5.20e-03 4.30e-02
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 6.96e-04 5.61e-03 0.47000 -0.461000 -0.090200 2.83e-03 5.59e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 71 7.84e-07 1.96e-05 0.46700 -0.361000 -0.296000 1.44e-07 1.58e-05
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 5.71e-02 1.60e-01 0.46700 0.286000 0.369000 6.36e-02 1.69e-02
EARLY PHASE OF HIV LIFE CYCLE 13 8.56e-02 2.07e-01 0.46600 -0.316000 -0.342000 4.88e-02 3.26e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 83 1.88e-07 6.15e-06 0.46200 -0.343000 -0.310000 6.85e-08 1.01e-06
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.55e-02 9.00e-02 0.46200 -0.356000 -0.294000 7.27e-03 2.65e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.52e-14 9.87e-12 0.46000 -0.319000 -0.332000 5.09e-13 6.46e-14
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 5.51e-02 1.58e-01 0.45900 0.289000 0.357000 5.26e-02 1.67e-02
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 1.46e-04 1.72e-03 0.45400 0.139000 0.432000 2.50e-01 3.33e-04
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 54 3.52e-05 5.52e-04 0.45300 -0.355000 -0.281000 6.42e-06 3.47e-04
DNA REPLICATION PRE INITIATION 80 4.09e-07 1.12e-05 0.45300 -0.346000 -0.292000 8.49e-08 6.40e-06
BRANCHED CHAIN AMINO ACID CATABOLISM 21 5.16e-03 2.67e-02 0.45300 -0.396000 -0.220000 1.70e-03 8.14e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 64 5.87e-06 1.21e-04 0.45200 -0.353000 -0.282000 1.03e-06 9.56e-05
PROTEIN UBIQUITINATION 70 7.52e-07 1.92e-05 0.45200 -0.367000 -0.264000 1.10e-07 1.38e-04
PROCESSING OF SMDT1 16 5.93e-02 1.64e-01 0.45100 -0.310000 -0.328000 3.17e-02 2.33e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 68 4.64e-06 9.74e-05 0.45100 -0.342000 -0.295000 1.12e-06 2.64e-05
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 15 5.05e-02 1.48e-01 0.44500 0.256000 0.364000 8.58e-02 1.47e-02
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 5.65e-02 1.59e-01 0.44200 0.308000 0.317000 2.81e-02 2.35e-02
DEGRADATION OF DVL 56 6.42e-05 8.68e-04 0.44000 -0.334000 -0.286000 1.52e-05 2.14e-04
INTERLEUKIN 12 SIGNALING 36 1.69e-03 1.11e-02 0.43900 -0.342000 -0.276000 3.79e-04 4.23e-03
HIV TRANSCRIPTION INITIATION 45 3.89e-04 3.63e-03 0.43900 -0.338000 -0.280000 8.65e-05 1.15e-03
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 3.59e-02 1.16e-01 0.43900 -0.314000 -0.307000 1.52e-02 1.75e-02
CRMPS IN SEMA3A SIGNALING 16 5.87e-02 1.63e-01 0.43800 0.342000 0.274000 1.78e-02 5.81e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 60 2.92e-05 4.90e-04 0.43700 -0.339000 -0.276000 5.66e-06 2.19e-04
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 3.11e-02 1.04e-01 0.43600 -0.349000 -0.261000 8.45e-03 4.93e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 18 6.54e-03 3.17e-02 0.43500 0.178000 0.398000 1.92e-01 3.50e-03
DNA REPLICATION 122 7.35e-10 5.33e-08 0.43400 -0.338000 -0.273000 1.13e-10 1.95e-07
ASPARTATE AND ASPARAGINE METABOLISM 11 8.21e-02 2.03e-01 0.43300 -0.213000 -0.378000 2.22e-01 3.02e-02
RAB GERANYLGERANYLATION 58 1.44e-05 2.82e-04 0.43200 -0.357000 -0.243000 2.51e-06 1.38e-03
PROCESSING AND ACTIVATION OF SUMO 10 1.27e-01 2.67e-01 0.43000 -0.366000 -0.227000 4.51e-02 2.14e-01
CITRIC ACID CYCLE TCA CYCLE 22 1.36e-02 5.45e-02 0.43000 -0.237000 -0.359000 5.47e-02 3.57e-03
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.11e-02 4.70e-02 0.43000 -0.339000 -0.264000 2.75e-03 2.00e-02
S PHASE 154 2.73e-12 3.91e-10 0.42900 -0.340000 -0.261000 3.14e-13 2.17e-08
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 3.19e-03 1.87e-02 0.42900 -0.356000 -0.239000 7.36e-04 2.35e-02
MET ACTIVATES RAP1 AND RAC1 10 1.89e-01 3.56e-01 0.42800 -0.330000 -0.273000 7.04e-02 1.35e-01
CS DS DEGRADATION 14 8.51e-02 2.07e-01 0.42700 0.255000 0.343000 9.90e-02 2.64e-02
GLUTATHIONE CONJUGATION 29 4.13e-03 2.29e-02 0.41900 -0.352000 -0.226000 1.03e-03 3.50e-02
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 3.15e-02 1.04e-01 0.41800 -0.384000 -0.165000 1.65e-02 3.03e-01
METHYLATION 11 7.58e-02 1.92e-01 0.41800 -0.374000 -0.187000 3.18e-02 2.83e-01
STABILIZATION OF P53 55 2.12e-04 2.33e-03 0.41700 -0.314000 -0.274000 5.55e-05 4.39e-04
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 9.42e-05 1.15e-03 0.41600 -0.347000 -0.229000 1.86e-05 4.62e-03
RRNA PROCESSING IN THE MITOCHONDRION 10 2.19e-01 3.93e-01 0.41500 -0.276000 -0.310000 1.30e-01 8.95e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 3.32e-05 5.35e-04 0.41500 -0.304000 -0.282000 1.23e-05 5.23e-05
CHOLESTEROL BIOSYNTHESIS 24 9.04e-03 3.94e-02 0.41300 -0.212000 -0.355000 7.24e-02 2.64e-03
DEGRADATION OF AXIN 54 1.61e-04 1.88e-03 0.41100 -0.329000 -0.246000 2.94e-05 1.76e-03
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 28 2.62e-03 1.61e-02 0.41000 -0.361000 -0.193000 9.39e-04 7.68e-02
RHOBTB3 ATPASE CYCLE 10 1.18e-01 2.55e-01 0.40800 -0.361000 -0.190000 4.81e-02 2.98e-01
DEGRADATION OF GLI1 BY THE PROTEASOME 58 1.39e-04 1.66e-03 0.40800 -0.318000 -0.255000 2.73e-05 7.90e-04
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 8.37e-03 3.77e-02 0.40700 -0.370000 -0.170000 4.15e-03 1.88e-01
PROTEIN METHYLATION 17 5.19e-02 1.51e-01 0.40600 -0.339000 -0.224000 1.56e-02 1.10e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 2.00e-01 3.68e-01 0.40600 -0.239000 -0.328000 1.90e-01 7.26e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 3.28e-06 7.15e-05 0.40500 -0.315000 -0.254000 5.81e-07 5.61e-05
CELLULAR RESPONSE TO HYPOXIA 73 2.67e-05 4.61e-04 0.40400 -0.305000 -0.264000 6.63e-06 9.49e-05
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 1.49e-02 5.81e-02 0.40300 0.279000 0.290000 8.09e-03 5.97e-03
PYRUVATE METABOLISM 27 1.34e-02 5.41e-02 0.40300 -0.327000 -0.236000 3.32e-03 3.41e-02
INTERLEUKIN 7 SIGNALING 19 6.91e-02 1.81e-01 0.40100 0.269000 0.297000 4.24e-02 2.49e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 1.70e-05 3.17e-04 0.40000 -0.294000 -0.271000 6.16e-06 3.20e-05
INSULIN RECEPTOR RECYCLING 20 3.34e-02 1.10e-01 0.39900 -0.334000 -0.218000 9.65e-03 9.11e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.14e-01 2.49e-01 0.39600 0.321000 0.231000 3.73e-02 1.35e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 2.00e-04 2.25e-03 0.39300 -0.326000 -0.220000 3.96e-05 5.71e-03
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 2.01e-02 7.48e-02 0.39200 -0.290000 -0.264000 6.78e-03 1.39e-02
FCERI MEDIATED NF KB ACTIVATION 77 3.72e-05 5.75e-04 0.39100 -0.285000 -0.268000 1.52e-05 4.91e-05
REGULATION OF TLR BY ENDOGENOUS LIGAND 14 1.56e-01 3.09e-01 0.39000 -0.286000 -0.266000 6.36e-02 8.54e-02
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 1.74e-03 1.13e-02 0.39000 0.212000 0.327000 2.20e-02 4.05e-04
UNWINDING OF DNA 12 7.84e-03 3.62e-02 0.38900 -0.386000 -0.048400 2.05e-02 7.72e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 3.76e-02 1.20e-01 0.38900 -0.299000 -0.249000 1.13e-02 3.45e-02
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 60 6.32e-05 8.65e-04 0.38800 -0.326000 -0.211000 1.28e-05 4.62e-03
SCAVENGING OF HEME FROM PLASMA 10 1.85e-01 3.51e-01 0.38600 -0.201000 -0.330000 2.70e-01 7.08e-02
REGULATION OF BACH1 ACTIVITY 11 2.17e-01 3.92e-01 0.38600 -0.303000 -0.238000 8.14e-02 1.72e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 2.86e-02 9.81e-02 0.38600 0.120000 0.366000 4.53e-01 2.22e-02
G1 S DNA DAMAGE CHECKPOINTS 66 2.18e-04 2.37e-03 0.38400 -0.266000 -0.278000 1.91e-04 9.46e-05
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.58e-01 3.11e-01 0.38400 -0.230000 -0.308000 1.51e-01 5.47e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 5.32e-02 1.53e-01 0.38200 0.135000 0.357000 4.20e-01 3.22e-02
PERK REGULATES GENE EXPRESSION 28 1.48e-02 5.81e-02 0.38200 -0.316000 -0.214000 3.81e-03 5.01e-02
FGFR2 MUTANT RECEPTOR ACTIVATION 27 3.26e-02 1.07e-01 0.38000 -0.253000 -0.283000 2.26e-02 1.09e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 6.77e-05 9.04e-04 0.37900 -0.379000 0.006570 3.33e-03 9.59e-01
FGFR2 LIGAND BINDING AND ACTIVATION 13 6.74e-02 1.78e-01 0.37900 -0.158000 -0.344000 3.25e-01 3.15e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 1.99e-02 7.46e-02 0.37900 -0.300000 -0.231000 5.20e-03 3.13e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.73e-01 3.33e-01 0.37800 -0.311000 -0.215000 6.18e-02 1.97e-01
PROTEIN LOCALIZATION 157 9.55e-10 5.91e-08 0.37800 -0.297000 -0.234000 1.32e-10 4.16e-07
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 2.20e-02 7.94e-02 0.37800 -0.369000 -0.083900 2.69e-02 6.15e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 22 5.88e-02 1.63e-01 0.37800 -0.290000 -0.243000 1.86e-02 4.87e-02
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 13 2.73e-02 9.46e-02 0.37800 0.109000 0.362000 4.98e-01 2.39e-02
MITOTIC G1 PHASE AND G1 S TRANSITION 141 5.47e-09 2.48e-07 0.37500 -0.301000 -0.224000 6.94e-10 4.28e-06
METALLOPROTEASE DUBS 25 3.02e-02 1.01e-01 0.37500 -0.217000 -0.306000 6.03e-02 8.18e-03
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 2.99e-04 2.94e-03 0.37200 0.319000 0.190000 7.97e-05 1.91e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 1.26e-06 3.09e-05 0.36900 -0.346000 -0.129000 4.27e-06 8.71e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 1.93e-01 3.61e-01 0.36800 -0.290000 -0.228000 7.07e-02 1.55e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 9.30e-02 2.20e-01 0.36700 -0.288000 -0.227000 2.98e-02 8.64e-02
SIGNALING BY NTRK3 TRKC 17 1.37e-01 2.84e-01 0.36500 0.244000 0.272000 8.22e-02 5.24e-02
PHASE II CONJUGATION OF COMPOUNDS 63 6.94e-05 9.09e-04 0.36400 -0.312000 -0.186000 1.80e-05 1.05e-02
HYALURONAN METABOLISM 15 1.80e-01 3.42e-01 0.36400 0.261000 0.254000 8.04e-02 8.91e-02
INTERLEUKIN RECEPTOR SHC SIGNALING 20 1.01e-01 2.33e-01 0.36400 0.264000 0.250000 4.10e-02 5.29e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 2.47e-02 8.73e-02 0.36300 -0.346000 -0.110000 2.03e-02 4.59e-01
INTERLEUKIN 15 SIGNALING 12 2.54e-01 4.36e-01 0.36300 0.262000 0.252000 1.17e-01 1.31e-01
G2 M CHECKPOINTS 133 2.73e-07 8.03e-06 0.36200 -0.265000 -0.247000 1.27e-07 9.03e-07
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 1.02e-02 4.38e-02 0.36100 -0.302000 -0.197000 2.64e-03 4.98e-02
OTHER SEMAPHORIN INTERACTIONS 19 7.70e-02 1.93e-01 0.36000 0.299000 0.201000 2.41e-02 1.30e-01
DARPP 32 EVENTS 23 4.81e-02 1.44e-01 0.36000 -0.296000 -0.205000 1.40e-02 8.92e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 3.39e-03 1.96e-02 0.35900 -0.251000 -0.258000 1.96e-03 1.47e-03
INTERLEUKIN 37 SIGNALING 18 8.27e-02 2.04e-01 0.35800 0.301000 0.193000 2.70e-02 1.56e-01
INTERLEUKIN 12 FAMILY SIGNALING 43 4.93e-03 2.63e-02 0.35600 -0.287000 -0.210000 1.11e-03 1.70e-02
REGULATION OF PTEN STABILITY AND ACTIVITY 68 1.73e-04 1.99e-03 0.35600 -0.292000 -0.204000 3.22e-05 3.58e-03
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 1.38e-01 2.86e-01 0.35500 0.136000 0.328000 4.58e-01 7.24e-02
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 1.38e-01 2.86e-01 0.35500 0.136000 0.328000 4.58e-01 7.24e-02
FORMATION OF APOPTOSOME 10 3.21e-01 5.04e-01 0.35500 -0.272000 -0.228000 1.36e-01 2.13e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 2.68e-01 4.52e-01 0.35300 0.195000 0.295000 2.86e-01 1.07e-01
TRANSLATION 287 2.46e-17 2.89e-14 0.35300 -0.297000 -0.190000 4.73e-18 3.23e-08
RAS PROCESSING 24 1.60e-02 6.22e-02 0.35300 -0.318000 -0.153000 7.05e-03 1.94e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 2.98e-02 1.01e-01 0.35200 -0.273000 -0.221000 8.43e-03 3.29e-02
MATURATION OF NUCLEOPROTEIN 10 1.68e-01 3.26e-01 0.35200 -0.320000 -0.147000 8.01e-02 4.22e-01
TRANSLESION SYNTHESIS BY POLK 17 1.52e-01 3.05e-01 0.35000 -0.269000 -0.224000 5.48e-02 1.10e-01
TRIGLYCERIDE CATABOLISM 14 1.55e-02 6.04e-02 0.34900 -0.344000 -0.060100 2.60e-02 6.97e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 1.46e-01 2.98e-01 0.34800 0.232000 0.260000 8.86e-02 5.60e-02
RHOC GTPASE CYCLE 74 3.82e-04 3.62e-03 0.34600 0.262000 0.226000 9.59e-05 7.90e-04
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 85 3.91e-05 5.89e-04 0.34600 -0.283000 -0.200000 6.74e-06 1.47e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 4.48e-02 1.37e-01 0.34600 -0.295000 -0.180000 1.43e-02 1.35e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 3.65e-02 1.18e-01 0.34600 0.335000 0.083600 3.63e-02 6.02e-01
RHOB GTPASE CYCLE 68 7.81e-04 6.04e-03 0.34500 0.260000 0.228000 2.15e-04 1.15e-03
CLEC7A DECTIN 1 SIGNALING 95 5.05e-05 7.24e-04 0.34500 -0.258000 -0.229000 1.45e-05 1.15e-04
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 9.29e-02 2.20e-01 0.34300 -0.297000 -0.171000 3.39e-02 2.23e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 1.09e-02 4.61e-02 0.34200 -0.204000 -0.275000 2.58e-02 2.63e-03
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.98e-01 4.83e-01 0.34100 -0.248000 -0.234000 1.37e-01 1.60e-01
NRAGE SIGNALS DEATH THROUGH JNK 55 2.99e-03 1.78e-02 0.34100 0.264000 0.216000 7.17e-04 5.56e-03
GP1B IX V ACTIVATION SIGNALLING 11 3.14e-01 4.96e-01 0.34000 0.263000 0.214000 1.30e-01 2.18e-01
INTERFERON ALPHA BETA SIGNALING 56 4.53e-15 2.66e-12 0.33800 -0.303000 0.150000 8.85e-05 5.16e-02
BIOTIN TRANSPORT AND METABOLISM 11 1.59e-01 3.13e-01 0.33800 0.139000 0.308000 4.24e-01 7.68e-02
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 1.04e-02 4.46e-02 0.33700 -0.028000 0.336000 8.72e-01 5.38e-02
NEUREXINS AND NEUROLIGINS 54 2.76e-03 1.66e-02 0.33700 0.270000 0.201000 5.97e-04 1.05e-02
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 2.06e-01 3.77e-01 0.33600 -0.248000 -0.227000 8.61e-02 1.15e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 9.79e-04 7.20e-03 0.33500 0.315000 0.115000 1.08e-03 2.33e-01
MRNA CAPPING 29 4.82e-02 1.44e-01 0.33500 -0.264000 -0.206000 1.40e-02 5.44e-02
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 2.46e-01 4.25e-01 0.33400 0.216000 0.255000 1.61e-01 9.82e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 9.63e-02 2.24e-01 0.33400 -0.319000 -0.099100 6.66e-02 5.69e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 1.04e-01 2.36e-01 0.33400 -0.222000 -0.250000 6.56e-02 3.81e-02
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 83 6.20e-05 8.57e-04 0.33400 -0.278000 -0.185000 1.19e-05 3.58e-03
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 2.86e-02 9.81e-02 0.33400 0.178000 0.283000 9.76e-02 8.41e-03
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 1.27e-01 2.67e-01 0.33300 -0.129000 -0.307000 4.39e-01 6.52e-02
GLUTATHIONE SYNTHESIS AND RECYCLING 11 3.29e-01 5.13e-01 0.33300 -0.258000 -0.212000 1.39e-01 2.24e-01
HS GAG DEGRADATION 21 9.38e-02 2.21e-01 0.33300 0.274000 0.189000 2.99e-02 1.34e-01
BUDDING AND MATURATION OF HIV VIRION 27 2.39e-02 8.55e-02 0.33200 -0.292000 -0.158000 8.58e-03 1.54e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 1.11e-01 2.45e-01 0.33200 -0.212000 -0.256000 8.55e-02 3.79e-02
DERMATAN SULFATE BIOSYNTHESIS 11 3.33e-01 5.18e-01 0.33200 0.256000 0.212000 1.42e-01 2.24e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 6.34e-03 3.08e-02 0.33200 -0.332000 0.002170 3.17e-02 9.89e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 5.24e-03 2.67e-02 0.33100 -0.327000 -0.051800 1.35e-02 6.96e-01
SULFUR AMINO ACID METABOLISM 23 6.75e-02 1.78e-01 0.33100 -0.278000 -0.180000 2.12e-02 1.35e-01
REGULATION OF RAS BY GAPS 67 9.56e-04 7.07e-03 0.33100 -0.263000 -0.200000 1.94e-04 4.65e-03
SIGNALING BY FGFR2 IIIA TM 19 1.21e-01 2.58e-01 0.33100 -0.272000 -0.188000 4.02e-02 1.56e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 4.39e-02 1.35e-01 0.33100 -0.240000 -0.227000 1.70e-02 2.39e-02
MET ACTIVATES PTK2 SIGNALING 28 5.24e-03 2.67e-02 0.33100 0.311000 0.113000 4.44e-03 3.00e-01
KINESINS 47 7.67e-04 6.01e-03 0.33000 0.298000 0.142000 4.04e-04 9.29e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 7.29e-03 3.43e-02 0.33000 0.201000 0.261000 1.58e-02 1.73e-03
FGFR1 LIGAND BINDING AND ACTIVATION 10 3.88e-01 5.78e-01 0.33000 -0.226000 -0.241000 2.16e-01 1.88e-01
FORMATION OF TC NER PRE INCISION COMPLEX 53 2.86e-03 1.71e-02 0.33000 -0.271000 -0.187000 6.36e-04 1.84e-02
PYROPTOSIS 21 7.96e-02 1.99e-01 0.32900 -0.280000 -0.174000 2.65e-02 1.68e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 4.86e-02 1.44e-01 0.32800 -0.313000 -0.099900 3.59e-02 5.03e-01
NEPHRIN FAMILY INTERACTIONS 23 1.17e-01 2.53e-01 0.32600 0.218000 0.242000 6.99e-02 4.42e-02
FORMATION OF INCISION COMPLEX IN GG NER 43 1.31e-02 5.35e-02 0.32500 -0.259000 -0.196000 3.26e-03 2.66e-02
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 4.37e-03 2.40e-02 0.32400 0.119000 0.301000 2.43e-01 3.18e-03
HEDGEHOG LIGAND BIOGENESIS 62 1.05e-03 7.65e-03 0.32200 -0.270000 -0.175000 2.39e-04 1.71e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 5.32e-02 1.53e-01 0.32100 -0.310000 -0.085200 4.49e-02 5.81e-01
RNA POLYMERASE I PROMOTER ESCAPE 46 2.24e-03 1.41e-02 0.32000 -0.284000 -0.147000 8.69e-04 8.38e-02
SEPARATION OF SISTER CHROMATIDS 166 4.80e-07 1.26e-05 0.32000 -0.226000 -0.226000 5.23e-07 4.93e-07
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION 10 1.14e-02 4.79e-02 0.32000 0.077500 -0.310000 6.71e-01 8.96e-02
C TYPE LECTIN RECEPTORS CLRS 114 2.64e-05 4.61e-04 0.32000 -0.247000 -0.202000 5.20e-06 1.89e-04
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 1.37e-02 5.48e-02 0.31900 -0.038500 0.317000 8.25e-01 6.90e-02
NGF STIMULATED TRANSCRIPTION 36 3.08e-05 5.09e-04 0.31900 -0.317000 -0.027500 9.81e-04 7.76e-01
ANTIGEN PROCESSING CROSS PRESENTATION 99 6.95e-06 1.39e-04 0.31900 -0.276000 -0.159000 2.08e-06 6.33e-03
IRON UPTAKE AND TRANSPORT 52 5.23e-03 2.67e-02 0.31800 -0.260000 -0.184000 1.20e-03 2.17e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 3.52e-02 1.14e-01 0.31800 0.178000 0.263000 8.07e-02 9.94e-03
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 1.20e-02 4.96e-02 0.31800 0.022500 0.317000 8.80e-01 3.34e-02
DNA STRAND ELONGATION 32 1.36e-03 9.33e-03 0.31800 -0.307000 -0.083600 2.67e-03 4.13e-01
N GLYCAN ANTENNAE ELONGATION 15 2.60e-04 2.73e-03 0.31700 -0.177000 0.263000 2.35e-01 7.78e-02
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 2.13e-01 3.86e-01 0.31600 -0.254000 -0.189000 7.86e-02 1.91e-01
CDC42 GTPASE CYCLE 154 1.40e-06 3.30e-05 0.31600 0.237000 0.209000 3.86e-07 7.88e-06
G2 M DNA DAMAGE CHECKPOINT 65 2.87e-03 1.71e-02 0.31600 -0.202000 -0.243000 4.97e-03 7.01e-04
CONDENSATION OF PROPHASE CHROMOSOMES 27 8.88e-03 3.90e-02 0.31600 -0.298000 -0.105000 7.42e-03 3.46e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 24 5.08e-03 2.67e-02 0.31500 -0.307000 -0.070500 9.14e-03 5.50e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 7.28e-03 3.43e-02 0.31400 -0.293000 -0.111000 5.43e-03 2.91e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 3.59e-01 5.47e-01 0.31300 -0.229000 -0.214000 1.69e-01 2.00e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 9.84e-03 4.24e-02 0.31300 0.190000 0.248000 2.01e-02 2.39e-03
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 1.42e-01 2.93e-01 0.31300 0.227000 0.215000 5.96e-02 7.42e-02
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 4.43e-02 1.36e-01 0.31200 -0.279000 -0.141000 1.81e-02 2.33e-01
EUKARYOTIC TRANSLATION INITIATION 115 4.86e-11 4.40e-09 0.31200 -0.303000 -0.075600 2.07e-08 1.62e-01
G PROTEIN ACTIVATION 22 2.69e-04 2.77e-03 0.31100 -0.039300 0.309000 7.50e-01 1.21e-02
CELL CYCLE CHECKPOINTS 241 2.43e-09 1.24e-07 0.31000 -0.216000 -0.223000 7.76e-09 2.70e-09
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 2.80e-04 2.85e-03 0.31000 0.254000 0.178000 5.34e-05 4.58e-03
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 1.70e-01 3.29e-01 0.31000 -0.183000 -0.250000 1.67e-01 5.96e-02
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 83 5.25e-05 7.44e-04 0.30900 -0.271000 -0.147000 1.93e-05 2.03e-02
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 23 4.04e-02 1.26e-01 0.30900 -0.281000 -0.127000 1.95e-02 2.93e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 7.09e-02 1.83e-01 0.30800 0.046900 0.304000 7.88e-01 8.04e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 1.62e-01 3.16e-01 0.30800 0.161000 0.263000 2.52e-01 6.07e-02
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 6.90e-02 1.81e-01 0.30500 0.184000 0.244000 8.13e-02 2.08e-02
HOST INTERACTIONS OF HIV FACTORS 126 1.58e-05 3.04e-04 0.30500 -0.243000 -0.184000 2.61e-06 3.59e-04
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 2.93e-01 4.79e-01 0.30400 0.161000 0.258000 3.33e-01 1.22e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 1.58e-01 3.11e-01 0.30400 -0.271000 -0.137000 6.88e-02 3.59e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 3.28e-02 1.08e-01 0.30300 0.214000 0.215000 1.50e-02 1.49e-02
SIGNALING BY FGFR2 IN DISEASE 37 5.31e-02 1.53e-01 0.30300 -0.216000 -0.213000 2.29e-02 2.53e-02
METABOLISM OF PORPHYRINS 19 1.80e-01 3.42e-01 0.30300 -0.246000 -0.178000 6.40e-02 1.80e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 34 7.02e-03 3.34e-02 0.30300 -0.281000 -0.113000 4.64e-03 2.53e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 3.28e-01 5.12e-01 0.30200 -0.184000 -0.239000 2.50e-01 1.36e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 2.26e-01 4.01e-01 0.30100 0.214000 0.211000 1.06e-01 1.11e-01
ACTIVATION OF RAC1 13 5.69e-02 1.60e-01 0.30100 -0.296000 -0.052300 6.44e-02 7.44e-01
PHASE 0 RAPID DEPOLARISATION 28 9.05e-02 2.16e-01 0.30100 0.239000 0.182000 2.85e-02 9.47e-02
RND2 GTPASE CYCLE 39 3.95e-02 1.25e-01 0.30000 0.187000 0.234000 4.34e-02 1.14e-02
DNA DAMAGE BYPASS 45 4.18e-03 2.31e-02 0.29800 -0.268000 -0.131000 1.87e-03 1.29e-01
SIGNALING BY NOTCH3 48 2.38e-04 2.55e-03 0.29800 0.084000 0.286000 3.14e-01 6.14e-04
ELASTIC FIBRE FORMATION 38 3.12e-03 1.84e-02 0.29800 0.102000 0.280000 2.75e-01 2.85e-03
RNA POLYMERASE III CHAIN ELONGATION 18 6.73e-02 1.78e-01 0.29800 -0.279000 -0.104000 4.04e-02 4.45e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 3.85e-01 5.75e-01 0.29800 -0.161000 -0.250000 3.78e-01 1.71e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 3.12e-05 5.10e-04 0.29700 -0.287000 -0.079000 1.61e-04 2.98e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 21 3.59e-02 1.16e-01 0.29700 -0.095100 -0.281000 4.51e-01 2.59e-02
ECM PROTEOGLYCANS 66 3.91e-03 2.19e-02 0.29600 0.237000 0.178000 8.71e-04 1.27e-02
REGULATION OF IFNA SIGNALING 12 2.19e-01 3.93e-01 0.29500 0.122000 0.269000 4.64e-01 1.07e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 14 3.51e-01 5.38e-01 0.29400 -0.207000 -0.209000 1.79e-01 1.76e-01
PURINE CATABOLISM 16 8.39e-02 2.06e-01 0.29400 -0.278000 -0.095300 5.39e-02 5.09e-01
METABOLISM OF COFACTORS 19 6.46e-02 1.74e-01 0.29400 -0.275000 -0.104000 3.81e-02 4.31e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 1.10e-01 2.44e-01 0.29400 -0.285000 -0.071700 8.73e-02 6.67e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 107 2.99e-12 3.91e-10 0.29400 -0.293000 -0.022700 1.68e-07 6.85e-01
REGULATION OF TNFR1 SIGNALING 34 1.98e-02 7.46e-02 0.29400 0.132000 0.263000 1.84e-01 8.07e-03
TRANSLESION SYNTHESIS BY POLH 19 1.02e-01 2.34e-01 0.29400 -0.265000 -0.127000 4.56e-02 3.39e-01
CYTOSOLIC TRNA AMINOACYLATION 24 1.03e-01 2.34e-01 0.29400 -0.156000 -0.249000 1.85e-01 3.50e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.43e-01 5.29e-01 0.29300 0.243000 0.164000 1.45e-01 3.25e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 1.36e-03 9.33e-03 0.29300 -0.285000 -0.066700 3.47e-03 4.95e-01
INTERLEUKIN 2 FAMILY SIGNALING 32 9.42e-02 2.21e-01 0.29200 0.207000 0.207000 4.31e-02 4.27e-02
MITOTIC METAPHASE AND ANAPHASE 207 2.28e-07 7.26e-06 0.29200 -0.217000 -0.196000 8.06e-08 1.24e-06
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 1.61e-01 3.15e-01 0.29200 0.245000 0.158000 5.82e-02 2.20e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 1.10e-01 2.44e-01 0.29100 -0.249000 -0.151000 3.89e-02 2.10e-01
HEME BIOSYNTHESIS 13 2.94e-01 4.80e-01 0.29000 -0.247000 -0.153000 1.23e-01 3.40e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 1.49e-02 5.81e-02 0.28900 -0.266000 -0.114000 8.20e-03 2.58e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 1.20e-01 2.57e-01 0.28900 -0.248000 -0.148000 4.38e-02 2.30e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 3.19e-01 5.02e-01 0.28900 -0.183000 -0.224000 2.21e-01 1.33e-01
PRE NOTCH PROCESSING IN GOLGI 17 2.94e-01 4.80e-01 0.28800 0.209000 0.199000 1.36e-01 1.56e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 1.18e-03 8.35e-03 0.28800 -0.271000 0.098100 5.35e-02 4.84e-01
CYTOPROTECTION BY HMOX1 119 1.81e-04 2.05e-03 0.28700 -0.216000 -0.189000 4.87e-05 3.62e-04
SIGNALING BY THE B CELL RECEPTOR BCR 104 3.33e-04 3.24e-03 0.28600 -0.227000 -0.174000 6.41e-05 2.17e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 34 4.11e-02 1.28e-01 0.28600 -0.245000 -0.147000 1.33e-02 1.39e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 3.87e-04 3.63e-03 0.28500 -0.282000 0.046100 1.69e-02 6.96e-01
PI 3K CASCADE FGFR2 17 2.34e-01 4.11e-01 0.28500 -0.158000 -0.238000 2.60e-01 8.98e-02
ION TRANSPORT BY P TYPE ATPASES 49 3.05e-02 1.02e-01 0.28500 0.213000 0.189000 9.96e-03 2.21e-02
HIV INFECTION 222 4.73e-08 1.74e-06 0.28500 -0.226000 -0.173000 6.53e-09 9.28e-06
MITOPHAGY 29 5.11e-02 1.49e-01 0.28400 -0.251000 -0.134000 1.94e-02 2.13e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 2.32e-02 8.33e-02 0.28400 -0.252000 -0.131000 8.89e-03 1.74e-01
NCAM1 INTERACTIONS 40 3.71e-02 1.19e-01 0.28400 0.234000 0.161000 1.05e-02 7.88e-02
G0 AND EARLY G1 25 1.77e-01 3.39e-01 0.28300 -0.199000 -0.202000 8.54e-02 8.05e-02
RND3 GTPASE CYCLE 38 4.84e-02 1.44e-01 0.28300 0.163000 0.231000 8.16e-02 1.39e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.78e-01 3.40e-01 0.28200 -0.267000 -0.090300 1.09e-01 5.88e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 1.41e-02 5.57e-02 0.28100 -0.281000 0.007470 5.20e-02 9.59e-01
MAPK6 MAPK4 SIGNALING 85 1.98e-03 1.26e-02 0.28000 -0.221000 -0.173000 4.31e-04 5.94e-03
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 2.93e-02 9.97e-02 0.28000 -0.275000 -0.053100 3.78e-02 6.88e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 152 1.77e-05 3.24e-04 0.28000 -0.219000 -0.175000 3.20e-06 1.98e-04
TCR SIGNALING 102 1.02e-03 7.42e-03 0.28000 -0.202000 -0.194000 4.30e-04 7.11e-04
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 96 7.75e-10 5.33e-08 0.27900 -0.278000 -0.026000 2.51e-06 6.60e-01
DISEASES OF MITOTIC CELL CYCLE 37 7.55e-02 1.91e-01 0.27900 -0.213000 -0.180000 2.48e-02 5.83e-02
LAGGING STRAND SYNTHESIS 20 8.39e-02 2.06e-01 0.27900 -0.259000 -0.105000 4.53e-02 4.18e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 1.48e-01 3.00e-01 0.27900 -0.158000 -0.230000 1.81e-01 5.14e-02
CHONDROITIN SULFATE BIOSYNTHESIS 18 3.02e-01 4.87e-01 0.27800 0.197000 0.195000 1.48e-01 1.51e-01
SIGNALING BY NOTCH2 33 5.72e-03 2.85e-02 0.27700 0.072900 0.267000 4.69e-01 7.89e-03
POLYMERASE SWITCHING 14 1.19e-01 2.56e-01 0.27700 -0.266000 -0.076500 8.50e-02 6.20e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 1.46e-01 2.98e-01 0.27700 0.190000 0.201000 7.69e-02 6.07e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 63 3.60e-03 2.07e-02 0.27600 -0.239000 -0.139000 1.06e-03 5.58e-02
PEXOPHAGY 11 3.51e-01 5.38e-01 0.27500 0.131000 0.242000 4.52e-01 1.64e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 1.92e-02 7.30e-02 0.27500 -0.029500 -0.274000 8.24e-01 3.89e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 4.49e-01 6.41e-01 0.27500 0.230000 0.151000 2.09e-01 4.07e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 2.84e-04 2.86e-03 0.27500 -0.204000 -0.184000 8.59e-05 4.14e-04
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 1.61e-03 1.07e-02 0.27500 -0.233000 -0.145000 4.04e-04 2.78e-02
FRS MEDIATED FGFR2 SIGNALING 19 2.10e-01 3.82e-01 0.27500 -0.147000 -0.232000 2.66e-01 8.04e-02
APOPTOTIC FACTOR MEDIATED RESPONSE 18 3.08e-01 4.91e-01 0.27500 -0.200000 -0.188000 1.42e-01 1.67e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 2.63e-01 4.45e-01 0.27400 0.101000 0.255000 5.61e-01 1.43e-01
G ALPHA 12 13 SIGNALLING EVENTS 75 5.35e-03 2.70e-02 0.27400 0.169000 0.215000 1.14e-02 1.26e-03
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.98e-02 7.46e-02 0.27400 -0.236000 -0.139000 6.18e-03 1.07e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 4.45e-04 3.96e-03 0.27400 -0.240000 -0.131000 1.54e-04 3.91e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.43e-01 4.23e-01 0.27300 -0.260000 -0.080900 1.54e-01 6.58e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 7.02e-02 1.83e-01 0.27300 0.258000 0.088300 4.59e-02 4.94e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 4.05e-01 5.97e-01 0.27200 0.185000 0.200000 2.30e-01 1.96e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 4.80e-01 6.66e-01 0.27200 0.221000 0.159000 2.26e-01 3.85e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 5.47e-02 1.57e-01 0.27200 0.149000 0.228000 1.16e-01 1.66e-02
PLASMA LIPOPROTEIN ASSEMBLY 11 9.59e-02 2.23e-01 0.27200 0.021600 0.271000 9.01e-01 1.19e-01
REGULATED NECROSIS 46 8.49e-03 3.80e-02 0.27200 -0.246000 -0.117000 3.93e-03 1.71e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 36 8.51e-02 2.07e-01 0.27200 -0.213000 -0.169000 2.70e-02 7.96e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 6.25e-02 1.71e-01 0.27000 -0.252000 -0.096700 3.64e-02 4.22e-01
THE NLRP3 INFLAMMASOME 14 3.43e-01 5.29e-01 0.26900 -0.225000 -0.148000 1.46e-01 3.37e-01
REPRESSION OF WNT TARGET GENES 14 7.24e-02 1.86e-01 0.26900 0.037700 0.266000 8.07e-01 8.45e-02
RHOA GTPASE CYCLE 143 1.40e-04 1.66e-03 0.26900 0.191000 0.189000 8.11e-05 9.38e-05
ERKS ARE INACTIVATED 13 2.79e-01 4.62e-01 0.26800 -0.241000 -0.118000 1.33e-01 4.62e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 8.85e-03 3.90e-02 0.26800 0.251000 0.093600 6.67e-03 3.12e-01
EUKARYOTIC TRANSLATION ELONGATION 88 1.11e-09 6.55e-08 0.26700 -0.267000 0.002140 1.49e-05 9.72e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 22 2.34e-01 4.11e-01 0.26700 0.209000 0.166000 8.97e-02 1.77e-01
DUAL INCISION IN TC NER 64 2.68e-03 1.63e-02 0.26700 -0.237000 -0.123000 1.05e-03 9.00e-02
HDMS DEMETHYLATE HISTONES 26 1.05e-01 2.36e-01 0.26700 0.130000 0.233000 2.51e-01 3.98e-02
TRAFFICKING OF AMPA RECEPTORS 31 1.46e-01 2.98e-01 0.26600 0.180000 0.197000 8.36e-02 5.79e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 4.73e-01 6.58e-01 0.26600 0.177000 0.199000 2.88e-01 2.33e-01
COHESIN LOADING ONTO CHROMATIN 10 3.42e-01 5.29e-01 0.26600 -0.105000 -0.244000 5.64e-01 1.81e-01
MUCOPOLYSACCHARIDOSES 11 4.66e-01 6.52e-01 0.26600 0.156000 0.215000 3.71e-01 2.16e-01
ANCHORING FIBRIL FORMATION 14 8.66e-03 3.86e-02 0.26600 0.249000 -0.091700 1.06e-01 5.53e-01
PEROXISOMAL PROTEIN IMPORT 58 7.39e-03 3.45e-02 0.26500 -0.231000 -0.130000 2.37e-03 8.60e-02
DCC MEDIATED ATTRACTIVE SIGNALING 14 2.62e-01 4.45e-01 0.26500 0.117000 0.238000 4.50e-01 1.24e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 2.66e-01 4.50e-01 0.26400 -0.241000 -0.109000 1.33e-01 4.96e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 7.88e-03 3.62e-02 0.26400 -0.205000 -0.166000 1.97e-03 1.24e-02
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 2.39e-01 4.18e-01 0.26400 -0.226000 -0.136000 9.69e-02 3.17e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 69 7.59e-03 3.52e-02 0.26400 -0.150000 -0.217000 3.12e-02 1.82e-03
G1 S SPECIFIC TRANSCRIPTION 27 1.91e-01 3.58e-01 0.26300 -0.172000 -0.199000 1.23e-01 7.37e-02
REGULATION OF EXPRESSION OF SLITS AND ROBOS 165 4.39e-09 2.07e-07 0.26200 -0.246000 -0.090600 4.85e-08 4.49e-02
TNFR2 NON CANONICAL NF KB PATHWAY 82 5.59e-04 4.78e-03 0.26100 -0.233000 -0.116000 2.59e-04 6.94e-02
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 7.65e-02 1.93e-01 0.26000 -0.260000 0.010200 1.35e-01 9.53e-01
SIGNALING BY NOTCH1 75 1.73e-03 1.13e-02 0.26000 0.124000 0.229000 6.44e-02 6.10e-04
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 3.15e-02 1.04e-01 0.25800 -0.250000 -0.065800 3.07e-02 5.69e-01
RET SIGNALING 36 1.11e-01 2.45e-01 0.25700 0.160000 0.201000 9.71e-02 3.68e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 1.41e-03 9.50e-03 0.25400 -0.076400 0.242000 5.35e-01 4.92e-02
EFFECTS OF PIP2 HYDROLYSIS 27 1.36e-01 2.83e-01 0.25400 0.218000 0.131000 5.02e-02 2.40e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 4.60e-01 6.49e-01 0.25200 0.185000 0.172000 2.31e-01 2.66e-01
FERTILIZATION 13 2.49e-01 4.29e-01 0.25200 0.236000 0.088300 1.41e-01 5.82e-01
NEUROTRANSMITTER RELEASE CYCLE 49 4.61e-02 1.39e-01 0.25200 0.146000 0.205000 7.66e-02 1.31e-02
ERK MAPK TARGETS 22 2.45e-01 4.25e-01 0.25100 -0.206000 -0.144000 9.39e-02 2.43e-01
SHC MEDIATED CASCADE FGFR1 16 3.90e-01 5.80e-01 0.25100 -0.198000 -0.155000 1.71e-01 2.84e-01
REGULATION OF INSULIN SECRETION 71 1.18e-03 8.35e-03 0.25100 0.099600 0.230000 1.47e-01 7.95e-04
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 1.16e-02 4.82e-02 0.25000 0.084200 0.236000 3.51e-01 9.04e-03
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 3.08e-01 4.91e-01 0.25000 0.085800 0.235000 6.22e-01 1.77e-01
RMTS METHYLATE HISTONE ARGININES 42 4.87e-02 1.44e-01 0.25000 0.127000 0.215000 1.53e-01 1.61e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 6.39e-02 1.73e-01 0.24900 -0.237000 -0.077000 4.46e-02 5.14e-01
FCGR3A MEDIATED IL10 SYNTHESIS 32 1.61e-01 3.15e-01 0.24800 0.155000 0.194000 1.30e-01 5.70e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 3.84e-02 1.22e-01 0.24800 0.187000 0.164000 1.24e-02 2.85e-02
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 3.92e-01 5.82e-01 0.24800 0.117000 0.219000 4.83e-01 1.89e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 1.46e-01 2.98e-01 0.24800 -0.240000 -0.062800 1.08e-01 6.74e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 4.66e-02 1.40e-01 0.24800 -0.138000 -0.206000 9.77e-02 1.37e-02
ENOS ACTIVATION 11 2.01e-01 3.69e-01 0.24800 -0.243000 -0.046100 1.63e-01 7.91e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 5.31e-01 7.09e-01 0.24700 0.173000 0.176000 2.99e-01 2.90e-01
DAG AND IP3 SIGNALING 40 1.12e-01 2.46e-01 0.24700 0.189000 0.159000 3.89e-02 8.13e-02
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 21 2.90e-02 9.92e-02 0.24700 -0.246000 -0.025300 5.15e-02 8.41e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 1.53e-01 3.05e-01 0.24700 -0.238000 -0.063800 1.10e-01 6.69e-01
SELENOAMINO ACID METABOLISM 110 6.18e-09 2.64e-07 0.24600 -0.245000 -0.021100 8.82e-06 7.02e-01
TNF SIGNALING 43 4.02e-02 1.26e-01 0.24600 0.118000 0.216000 1.79e-01 1.44e-02
PEROXISOMAL LIPID METABOLISM 26 2.49e-01 4.29e-01 0.24600 -0.185000 -0.162000 1.02e-01 1.53e-01
CELLULAR RESPONSE TO STARVATION 147 8.16e-10 5.33e-08 0.24600 -0.241000 -0.046200 4.43e-07 3.34e-01
INOSITOL PHOSPHATE METABOLISM 46 6.36e-02 1.72e-01 0.24600 0.200000 0.142000 1.90e-02 9.46e-02
INTEGRATION OF ENERGY METABOLISM 99 4.27e-04 3.87e-03 0.24500 0.112000 0.218000 5.33e-02 1.78e-04
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 1.71e-02 6.59e-02 0.24500 -0.233000 -0.076700 1.43e-02 4.19e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 62 2.95e-02 1.00e-01 0.24400 -0.147000 -0.195000 4.59e-02 7.97e-03
INTERFERON GAMMA SIGNALING 78 3.95e-09 1.94e-07 0.24400 -0.239000 0.048400 2.65e-04 4.60e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 4.63e-01 6.52e-01 0.24400 -0.174000 -0.171000 2.44e-01 2.52e-01
RA BIOSYNTHESIS PATHWAY 14 4.53e-01 6.44e-01 0.24300 -0.147000 -0.194000 3.42e-01 2.08e-01
INTEGRIN SIGNALING 24 2.34e-01 4.11e-01 0.24300 0.138000 0.201000 2.42e-01 8.91e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.10e-01 4.94e-01 0.24300 -0.175000 -0.168000 1.47e-01 1.62e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 5.01e-01 6.84e-01 0.24200 0.122000 0.209000 5.06e-01 2.52e-01
INTERLEUKIN 1 SIGNALING 96 5.26e-03 2.67e-02 0.24200 -0.191000 -0.148000 1.22e-03 1.23e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 9.42e-02 2.21e-01 0.24100 -0.237000 -0.044500 9.05e-02 7.51e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 4.31e-04 3.87e-03 0.24100 -0.146000 0.192000 2.17e-01 1.03e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 22 2.22e-01 3.95e-01 0.24000 -0.120000 -0.208000 3.31e-01 9.10e-02
NUCLEOTIDE EXCISION REPAIR 109 4.57e-04 4.01e-03 0.24000 -0.210000 -0.116000 1.51e-04 3.61e-02
MITOTIC SPINDLE CHECKPOINT 96 8.14e-03 3.68e-02 0.24000 -0.160000 -0.178000 6.62e-03 2.59e-03
RHOV GTPASE CYCLE 33 1.54e-01 3.06e-01 0.23900 0.140000 0.194000 1.65e-01 5.32e-02
PRE NOTCH EXPRESSION AND PROCESSING 62 2.80e-02 9.66e-02 0.23800 0.136000 0.196000 6.47e-02 7.61e-03
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 2.43e-02 8.67e-02 0.23800 -0.199000 -0.131000 6.76e-03 7.52e-02
RHOU GTPASE CYCLE 34 1.50e-01 3.03e-01 0.23800 0.139000 0.193000 1.60e-01 5.15e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.78e-01 4.62e-01 0.23800 0.118000 0.206000 3.73e-01 1.20e-01
TRANSCRIPTION OF THE HIV GENOME 67 2.73e-02 9.46e-02 0.23800 -0.190000 -0.143000 7.31e-03 4.27e-02
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 7.52e-03 3.50e-02 0.23800 0.097000 0.217000 1.98e-01 3.98e-03
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 4.14e-01 6.07e-01 0.23700 0.173000 0.162000 2.03e-01 2.34e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 1.21e-01 2.58e-01 0.23700 -0.216000 -0.098700 5.70e-02 3.84e-01
GLYCOGEN SYNTHESIS 14 3.82e-01 5.71e-01 0.23700 -0.207000 -0.115000 1.80e-01 4.56e-01
SIGNALING BY NOTCH4 83 4.20e-04 3.86e-03 0.23700 -0.222000 -0.083600 4.85e-04 1.88e-01
ABC TRANSPORTER DISORDERS 70 1.78e-02 6.83e-02 0.23700 -0.196000 -0.133000 4.66e-03 5.46e-02
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 1.34e-01 2.80e-01 0.23600 0.177000 0.156000 4.99e-02 8.41e-02
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 9.50e-02 2.22e-01 0.23600 -0.118000 -0.204000 2.19e-01 3.44e-02
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 1.60e-01 3.13e-01 0.23500 -0.218000 -0.089100 8.41e-02 4.80e-01
INTERLEUKIN 6 FAMILY SIGNALING 20 3.66e-01 5.55e-01 0.23500 0.149000 0.182000 2.50e-01 1.59e-01
SIALIC ACID METABOLISM 32 1.96e-01 3.64e-01 0.23300 -0.184000 -0.143000 7.17e-02 1.60e-01
EPHRIN SIGNALING 19 4.52e-02 1.37e-01 0.23300 0.012700 0.233000 9.24e-01 7.88e-02
CA2 PATHWAY 58 7.38e-04 5.82e-03 0.23300 0.047800 0.228000 5.29e-01 2.67e-03
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 64 4.56e-03 2.47e-02 0.23300 -0.215000 -0.089400 2.96e-03 2.16e-01
GLYCOSPHINGOLIPID METABOLISM 38 1.57e-01 3.11e-01 0.23300 -0.150000 -0.178000 1.11e-01 5.73e-02
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.51e-01 5.38e-01 0.23200 -0.199000 -0.120000 1.56e-01 3.92e-01
CHROMOSOME MAINTENANCE 100 5.27e-03 2.67e-02 0.23100 -0.188000 -0.136000 1.20e-03 1.92e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 4.26e-01 6.17e-01 0.23100 -0.206000 -0.104000 2.16e-01 5.32e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 19 2.93e-01 4.80e-01 0.23100 -0.201000 -0.114000 1.29e-01 3.92e-01
ONCOGENE INDUCED SENESCENCE 32 1.87e-01 3.53e-01 0.23100 0.135000 0.187000 1.86e-01 6.70e-02
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 7.93e-04 6.06e-03 0.23000 -0.091400 0.211000 4.11e-01 5.76e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 6.46e-02 1.74e-01 0.23000 0.165000 0.160000 2.70e-02 3.20e-02
RAF ACTIVATION 34 1.70e-01 3.29e-01 0.23000 -0.186000 -0.134000 5.99e-02 1.75e-01
TRIGLYCERIDE METABOLISM 24 5.96e-02 1.65e-01 0.23000 -0.224000 -0.050400 5.75e-02 6.69e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 4.48e-01 6.41e-01 0.23000 -0.149000 -0.175000 2.89e-01 2.12e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 5.51e-01 7.28e-01 0.22900 -0.170000 -0.153000 2.88e-01 3.41e-01
FATTY ACYL COA BIOSYNTHESIS 32 1.95e-01 3.62e-01 0.22800 -0.185000 -0.134000 7.05e-02 1.90e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 87 1.99e-02 7.46e-02 0.22800 0.166000 0.156000 7.42e-03 1.17e-02
SYNTHESIS OF PA 29 2.24e-01 3.99e-01 0.22800 0.186000 0.132000 8.39e-02 2.20e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 8.80e-02 2.11e-01 0.22700 -0.217000 -0.068200 6.08e-02 5.55e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 1.73e-01 3.33e-01 0.22700 -0.227000 0.006920 2.14e-01 9.70e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 5.19e-03 2.67e-02 0.22600 -0.060700 0.217000 6.15e-01 7.12e-02
METABOLISM OF AMINO ACIDS AND DERIVATIVES 319 1.26e-12 2.44e-10 0.22500 -0.212000 -0.077100 8.31e-11 1.82e-02
ANTIMICROBIAL PEPTIDES 17 4.31e-01 6.24e-01 0.22500 -0.182000 -0.133000 1.95e-01 3.42e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 2.03e-02 7.49e-02 0.22500 0.032600 0.223000 7.57e-01 3.49e-02
G PROTEIN MEDIATED EVENTS 51 1.08e-01 2.42e-01 0.22500 0.159000 0.159000 4.94e-02 4.95e-02
FATTY ACID METABOLISM 146 3.51e-04 3.39e-03 0.22400 -0.189000 -0.120000 7.96e-05 1.23e-02
RESOLUTION OF SISTER CHROMATID COHESION 101 8.02e-03 3.66e-02 0.22400 -0.135000 -0.179000 1.91e-02 1.90e-03
MTORC1 MEDIATED SIGNALLING 24 2.74e-01 4.56e-01 0.22400 -0.188000 -0.121000 1.11e-01 3.05e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 2.62e-02 9.14e-02 0.22300 0.167000 -0.148000 2.98e-01 3.55e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 1.44e-01 2.95e-01 0.22300 0.135000 0.178000 1.35e-01 4.91e-02
PROGRAMMED CELL DEATH 188 4.71e-05 7.01e-04 0.22300 -0.187000 -0.121000 9.61e-06 4.31e-03
IRAK4 DEFICIENCY TLR2 4 15 4.85e-01 6.68e-01 0.22300 -0.132000 -0.179000 3.76e-01 2.29e-01
UCH PROTEINASES 90 7.07e-03 3.35e-02 0.22200 -0.189000 -0.117000 1.93e-03 5.55e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 49 1.86e-02 7.12e-02 0.22200 0.080200 0.207000 3.32e-01 1.20e-02
NEDDYLATION 220 8.18e-05 1.02e-03 0.22200 -0.165000 -0.148000 2.39e-05 1.62e-04
CELLULAR HEXOSE TRANSPORT 11 3.01e-01 4.86e-01 0.22200 0.049100 0.216000 7.78e-01 2.14e-01
PKMTS METHYLATE HISTONE LYSINES 47 1.13e-01 2.47e-01 0.22200 0.176000 0.135000 3.69e-02 1.10e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 2.49e-01 4.30e-01 0.22200 -0.172000 -0.140000 9.80e-02 1.77e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 4.19e-01 6.12e-01 0.22200 -0.167000 -0.146000 1.96e-01 2.60e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 2.96e-02 1.00e-01 0.22100 0.088700 0.203000 2.88e-01 1.51e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 2.85e-01 4.71e-01 0.22100 -0.082600 -0.205000 5.68e-01 1.55e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 5.70e-01 7.39e-01 0.22100 -0.146000 -0.166000 3.64e-01 2.99e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 3.08e-01 4.91e-01 0.22100 0.137000 0.173000 2.27e-01 1.26e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 5.61e-01 7.35e-01 0.22000 0.171000 0.138000 2.85e-01 3.88e-01
BILE ACID AND BILE SALT METABOLISM 24 3.96e-02 1.25e-01 0.22000 0.219000 0.021600 6.37e-02 8.55e-01
INFLUENZA INFECTION 146 3.62e-07 1.01e-05 0.22000 -0.213000 -0.053900 8.98e-06 2.62e-01
NICOTINAMIDE SALVAGING 15 2.29e-01 4.06e-01 0.21900 -0.212000 -0.057900 1.56e-01 6.98e-01
RAC1 GTPASE CYCLE 179 3.78e-04 3.61e-03 0.21900 0.172000 0.136000 7.60e-05 1.77e-03
MITOTIC G2 G2 M PHASES 186 7.41e-05 9.58e-04 0.21800 -0.117000 -0.184000 6.09e-03 1.59e-05
DISEASES OF PROGRAMMED CELL DEATH 53 1.40e-02 5.55e-02 0.21800 -0.204000 -0.075100 1.01e-02 3.45e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 5.55e-01 7.31e-01 0.21700 0.130000 0.174000 4.16e-01 2.78e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 2.79e-01 4.62e-01 0.21700 0.185000 0.113000 1.16e-01 3.40e-01
MISMATCH REPAIR 14 1.73e-01 3.33e-01 0.21700 -0.215000 -0.026900 1.63e-01 8.62e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 5.62e-03 2.83e-02 0.21700 -0.126000 0.176000 3.30e-01 1.72e-01
HSF1 ACTIVATION 26 3.39e-01 5.25e-01 0.21700 -0.142000 -0.164000 2.10e-01 1.49e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 4.40e-01 6.34e-01 0.21600 0.175000 0.128000 2.00e-01 3.49e-01
OLFACTORY SIGNALING PATHWAY 31 1.23e-01 2.60e-01 0.21600 0.197000 0.089500 5.81e-02 3.88e-01
M PHASE 339 1.49e-06 3.43e-05 0.21600 -0.152000 -0.154000 1.61e-06 1.23e-06
RRNA PROCESSING 195 2.42e-07 7.50e-06 0.21500 -0.202000 -0.074800 1.16e-06 7.22e-02
PYRIMIDINE CATABOLISM 10 3.63e-01 5.51e-01 0.21500 -0.049200 -0.209000 7.88e-01 2.52e-01
SYNTHESIS OF PE 13 5.93e-01 7.52e-01 0.21500 0.158000 0.146000 3.25e-01 3.62e-01
NONSENSE MEDIATED DECAY NMD 110 9.83e-08 3.30e-06 0.21500 -0.215000 -0.002450 1.02e-04 9.65e-01
FCERI MEDIATED MAPK ACTIVATION 28 1.92e-01 3.59e-01 0.21400 -0.190000 -0.099900 8.23e-02 3.60e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 2.62e-01 4.45e-01 0.21400 -0.119000 -0.178000 2.75e-01 1.03e-01
SENSORY PROCESSING OF SOUND 61 8.05e-02 2.01e-01 0.21400 0.165000 0.137000 2.62e-02 6.52e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 6.73e-02 1.78e-01 0.21400 -0.205000 0.060400 2.01e-01 7.06e-01
TELOMERE MAINTENANCE 77 1.29e-02 5.26e-02 0.21300 -0.187000 -0.102000 4.49e-03 1.21e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 5.25e-02 1.52e-01 0.21300 -0.083700 0.196000 6.01e-01 2.21e-01
RHO GTPASES ACTIVATE KTN1 11 6.33e-01 7.83e-01 0.21300 -0.166000 -0.134000 3.42e-01 4.42e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 1.48e-01 3.00e-01 0.21300 -0.204000 -0.062300 9.84e-02 6.13e-01
HIV LIFE CYCLE 142 2.55e-03 1.58e-02 0.21200 -0.168000 -0.130000 5.62e-04 7.38e-03
TRNA PROCESSING IN THE NUCLEUS 56 1.10e-01 2.44e-01 0.21200 -0.142000 -0.158000 6.61e-02 4.11e-02
COLLAGEN CHAIN TRIMERIZATION 41 5.58e-05 7.82e-04 0.21200 0.106000 -0.184000 2.42e-01 4.17e-02
METABOLISM OF STEROID HORMONES 21 3.69e-01 5.58e-01 0.21200 -0.116000 -0.177000 3.57e-01 1.61e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 1.93e-01 3.61e-01 0.21200 -0.142000 -0.157000 1.12e-01 7.86e-02
G ALPHA S SIGNALLING EVENTS 108 6.42e-04 5.32e-03 0.21100 0.082600 0.194000 1.38e-01 4.87e-04
TRAF6 MEDIATED IRF7 ACTIVATION 15 7.93e-02 1.99e-01 0.21100 -0.023900 0.210000 8.73e-01 1.60e-01
CHROMATIN MODIFYING ENZYMES 219 2.43e-04 2.57e-03 0.21100 0.147000 0.151000 1.85e-04 1.16e-04
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 1.15e-01 2.50e-01 0.21000 0.142000 0.156000 6.69e-02 4.40e-02
COPII MEDIATED VESICLE TRANSPORT 66 8.42e-03 3.78e-02 0.21000 -0.196000 -0.075800 5.94e-03 2.87e-01
RHOBTB2 GTPASE CYCLE 23 4.20e-01 6.12e-01 0.20900 -0.147000 -0.149000 2.23e-01 2.16e-01
DUAL INCISION IN GG NER 40 4.90e-02 1.45e-01 0.20800 -0.196000 -0.070200 3.18e-02 4.42e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 5.20e-01 6.99e-01 0.20800 -0.165000 -0.127000 2.54e-01 3.78e-01
CELL CYCLE MITOTIC 473 2.33e-08 8.82e-07 0.20800 -0.156000 -0.138000 7.00e-09 3.11e-07
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 4.10e-03 2.28e-02 0.20800 -0.067400 0.196000 5.44e-01 7.73e-02
PCP CE PATHWAY 90 1.14e-02 4.79e-02 0.20700 -0.179000 -0.106000 3.43e-03 8.35e-02
SEMAPHORIN INTERACTIONS 64 4.95e-02 1.46e-01 0.20700 0.175000 0.111000 1.53e-02 1.25e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 6.73e-02 1.78e-01 0.20700 0.147000 0.145000 2.94e-02 3.17e-02
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 53 1.15e-01 2.51e-01 0.20700 0.125000 0.165000 1.16e-01 3.77e-02
APOPTOSIS 166 4.97e-04 4.30e-03 0.20700 -0.174000 -0.112000 1.11e-04 1.30e-02
SIGNALING BY INSULIN RECEPTOR 64 9.04e-02 2.16e-01 0.20700 -0.155000 -0.137000 3.25e-02 5.76e-02
DISEASES OF GLYCOSYLATION 124 8.84e-03 3.90e-02 0.20600 0.158000 0.133000 2.37e-03 1.08e-02
SARS COV 1 INFECTION 48 3.18e-02 1.05e-01 0.20600 -0.193000 -0.072000 2.05e-02 3.88e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 4.69e-01 6.55e-01 0.20600 0.195000 0.067200 2.86e-01 7.13e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 14 8.56e-02 2.07e-01 0.20500 -0.201000 0.040000 1.92e-01 7.96e-01
G PROTEIN BETA GAMMA SIGNALLING 31 5.26e-03 2.67e-02 0.20500 -0.202000 0.033600 5.13e-02 7.46e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.90e-01 3.57e-01 0.20500 -0.131000 -0.157000 1.32e-01 7.16e-02
SPHINGOLIPID METABOLISM 79 5.64e-02 1.59e-01 0.20400 -0.151000 -0.138000 2.02e-02 3.47e-02
GAP JUNCTION ASSEMBLY 21 4.71e-01 6.56e-01 0.20400 -0.142000 -0.146000 2.61e-01 2.47e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 7.41e-02 1.89e-01 0.20300 -0.165000 -0.119000 2.25e-02 9.99e-02
METABOLISM OF FAT SOLUBLE VITAMINS 32 2.96e-01 4.81e-01 0.20300 0.127000 0.159000 2.15e-01 1.20e-01
MITOTIC PROPHASE 93 1.21e-03 8.44e-03 0.20300 -0.192000 -0.067400 1.41e-03 2.62e-01
DNA DAMAGE RECOGNITION IN GG NER 38 9.54e-02 2.23e-01 0.20300 -0.186000 -0.080900 4.73e-02 3.88e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 4.04e-01 5.97e-01 0.20300 0.177000 0.098200 1.93e-01 4.71e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 1.90e-01 3.57e-01 0.20300 0.087200 0.183000 4.16e-01 8.85e-02
FLT3 SIGNALING IN DISEASE 28 3.68e-01 5.58e-01 0.20200 0.149000 0.136000 1.71e-01 2.13e-01
COSTIMULATION BY THE CD28 FAMILY 50 5.75e-02 1.61e-01 0.20100 -0.182000 -0.085500 2.60e-02 2.96e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.14e-01 2.49e-01 0.20100 -0.011300 -0.201000 9.34e-01 1.40e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 6.69e-01 8.14e-01 0.20100 -0.154000 -0.129000 3.75e-01 4.60e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 4.10e-01 6.04e-01 0.20100 -0.092700 -0.178000 5.08e-01 2.03e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 1.47e-01 2.98e-01 0.20100 0.195000 -0.046600 2.62e-01 7.89e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 3.36e-01 5.21e-01 0.20000 -0.199000 -0.022700 2.76e-01 9.01e-01
SIGNAL AMPLIFICATION 30 1.46e-03 9.81e-03 0.20000 -0.108000 0.168000 3.04e-01 1.11e-01
BIOLOGICAL OXIDATIONS 125 2.48e-03 1.54e-02 0.20000 -0.174000 -0.098100 7.83e-04 5.85e-02
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 1.88e-01 3.55e-01 0.20000 -0.050200 -0.193000 6.98e-01 1.34e-01
RESOLUTION OF D LOOP STRUCTURES 30 6.35e-02 1.72e-01 0.19900 -0.040200 -0.195000 7.03e-01 6.41e-02
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 1.29e-01 2.72e-01 0.19900 -0.061900 -0.189000 5.71e-01 8.29e-02
PLASMA LIPOPROTEIN REMODELING 13 2.75e-01 4.57e-01 0.19900 0.031400 0.197000 8.45e-01 2.20e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 16 5.78e-01 7.42e-01 0.19900 -0.139000 -0.143000 3.37e-01 3.23e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 25 1.36e-01 2.83e-01 0.19900 0.052900 0.191000 6.47e-01 9.77e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 6.26e-01 7.79e-01 0.19800 0.154000 0.125000 3.36e-01 4.36e-01
PROLONGED ERK ACTIVATION EVENTS 14 6.08e-01 7.68e-01 0.19800 -0.126000 -0.152000 4.14e-01 3.23e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 2.14e-01 3.87e-01 0.19800 -0.050400 -0.191000 7.03e-01 1.49e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 5.46e-01 7.24e-01 0.19700 -0.138000 -0.141000 3.13e-01 3.00e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 5.63e-01 7.36e-01 0.19700 0.095000 0.173000 5.69e-01 3.01e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 20 5.57e-02 1.59e-01 0.19600 -0.195000 0.020300 1.31e-01 8.75e-01
HOMOLOGY DIRECTED REPAIR 105 1.47e-02 5.81e-02 0.19600 -0.109000 -0.163000 5.42e-02 3.85e-03
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 5.69e-01 7.38e-01 0.19500 -0.132000 -0.144000 3.47e-01 3.05e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 3.86e-01 5.76e-01 0.19500 0.186000 0.056300 2.45e-01 7.25e-01
NONHOMOLOGOUS END JOINING NHEJ 42 2.26e-01 4.01e-01 0.19500 -0.119000 -0.154000 1.80e-01 8.50e-02
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 2.01e-01 3.69e-01 0.19400 0.070300 0.181000 5.35e-01 1.10e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 110 1.67e-02 6.46e-02 0.19400 -0.158000 -0.113000 4.24e-03 4.12e-02
CELL CYCLE 590 8.46e-09 3.37e-07 0.19400 -0.139000 -0.135000 8.53e-09 2.27e-08
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 2.22e-03 1.41e-02 0.19400 -0.124000 0.149000 2.49e-01 1.64e-01
MITOTIC TELOPHASE CYTOKINESIS 13 1.83e-01 3.47e-01 0.19400 0.008800 -0.194000 9.56e-01 2.27e-01
SIGNALING BY ROBO RECEPTORS 210 6.19e-08 2.14e-06 0.19400 -0.188000 -0.047200 2.71e-06 2.39e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 6.00e-02 1.66e-01 0.19400 0.193000 -0.012900 1.25e-01 9.19e-01
LAMININ INTERACTIONS 28 1.49e-01 3.01e-01 0.19300 0.183000 0.061200 9.31e-02 5.75e-01
GABA B RECEPTOR ACTIVATION 40 2.02e-02 7.48e-02 0.19300 0.025900 0.191000 7.77e-01 3.62e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 2.34e-01 4.11e-01 0.19300 -0.180000 -0.070900 1.28e-01 5.48e-01
PECAM1 INTERACTIONS 12 5.52e-01 7.29e-01 0.19300 0.087000 0.172000 6.02e-01 3.02e-01
INTERFERON SIGNALING 166 2.11e-11 2.25e-09 0.19300 -0.190000 0.031000 2.38e-05 4.91e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 1.24e-01 2.62e-01 0.19200 -0.159000 -0.108000 4.16e-02 1.66e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 1.42e-01 2.93e-01 0.19200 -0.167000 0.094600 3.62e-01 6.04e-01
PI 3K CASCADE FGFR1 16 5.81e-01 7.44e-01 0.19100 -0.150000 -0.118000 2.99e-01 4.13e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 3.60e-03 2.07e-02 0.19100 -0.187000 -0.040000 7.76e-03 5.68e-01
REGULATION OF KIT SIGNALING 16 3.76e-01 5.66e-01 0.19000 0.065700 0.178000 6.49e-01 2.18e-01
AMINO ACIDS REGULATE MTORC1 51 8.36e-02 2.06e-01 0.18900 -0.170000 -0.083600 3.59e-02 3.02e-01
ARACHIDONIC ACID METABOLISM 40 7.65e-02 1.93e-01 0.18900 -0.179000 -0.060800 5.00e-02 5.06e-01
TP53 REGULATES METABOLIC GENES 87 6.65e-02 1.77e-01 0.18900 -0.127000 -0.140000 4.10e-02 2.40e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 95 4.04e-02 1.26e-01 0.18900 -0.150000 -0.114000 1.14e-02 5.56e-02
TRAF6 MEDIATED NF KB ACTIVATION 22 1.03e-01 2.35e-01 0.18800 0.013800 0.188000 9.11e-01 1.27e-01
DNA METHYLATION 19 1.35e-01 2.81e-01 0.18800 -0.188000 -0.010400 1.57e-01 9.37e-01
FRS MEDIATED FGFR1 SIGNALING 18 5.73e-01 7.40e-01 0.18800 -0.140000 -0.125000 3.04e-01 3.58e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.08e-01 3.79e-01 0.18700 0.032800 -0.184000 8.51e-01 2.90e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 1.57e-01 3.11e-01 0.18700 0.038100 0.183000 7.52e-01 1.29e-01
MET PROMOTES CELL MOTILITY 38 9.71e-02 2.25e-01 0.18700 0.176000 0.061900 6.00e-02 5.09e-01
INITIAL TRIGGERING OF COMPLEMENT 13 5.15e-01 6.95e-01 0.18700 0.170000 0.076800 2.88e-01 6.32e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 119 1.25e-02 5.12e-02 0.18600 0.156000 0.101000 3.32e-03 5.71e-02
CD28 CO STIMULATION 31 3.02e-01 4.87e-01 0.18500 -0.158000 -0.096600 1.28e-01 3.52e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 4.92e-01 6.75e-01 0.18500 -0.055700 -0.176000 7.49e-01 3.11e-01
CHAPERONE MEDIATED AUTOPHAGY 21 3.33e-01 5.18e-01 0.18500 -0.170000 -0.072400 1.77e-01 5.66e-01
BASE EXCISION REPAIR 55 2.17e-02 7.88e-02 0.18500 -0.178000 -0.048300 2.23e-02 5.36e-01
MEIOTIC RECOMBINATION 36 1.96e-01 3.64e-01 0.18400 -0.165000 -0.082800 8.74e-02 3.90e-01
NUCLEOBASE BIOSYNTHESIS 15 3.54e-01 5.40e-01 0.18400 -0.178000 -0.048500 2.33e-01 7.45e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 88 1.23e-02 5.04e-02 0.18300 -0.073800 -0.168000 2.32e-01 6.52e-03
FLT3 SIGNALING 36 3.07e-01 4.91e-01 0.18300 0.108000 0.148000 2.61e-01 1.24e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.19e-01 2.55e-01 0.18300 0.035200 0.180000 7.51e-01 1.06e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 2.74e-01 4.56e-01 0.18300 -0.152000 -0.102000 1.09e-01 2.83e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 5.78e-01 7.42e-01 0.18300 0.127000 0.131000 3.37e-01 3.22e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 5.69e-01 7.38e-01 0.18300 -0.162000 -0.084000 3.11e-01 6.00e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 5.02e-01 6.84e-01 0.18300 -0.167000 -0.074400 2.80e-01 6.30e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 6.46e-01 7.95e-01 0.18200 -0.104000 -0.150000 5.15e-01 3.51e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 2.14e-02 7.78e-02 0.18200 0.010500 0.182000 9.09e-01 4.96e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 2.37e-01 4.15e-01 0.18200 -0.152000 -0.099200 9.21e-02 2.72e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 4.23e-01 6.14e-01 0.18100 -0.176000 -0.041900 2.90e-01 8.02e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 2.71e-01 4.55e-01 0.18000 -0.157000 -0.088000 1.18e-01 3.82e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 7.04e-01 8.37e-01 0.18000 -0.146000 -0.106000 4.02e-01 5.43e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 64 1.09e-01 2.43e-01 0.18000 -0.098200 -0.151000 1.75e-01 3.65e-02
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 6.29e-02 1.71e-01 0.18000 0.092000 0.155000 1.71e-01 2.13e-02
METABOLISM OF RNA 646 1.47e-09 8.21e-08 0.17900 -0.147000 -0.102000 1.93e-10 9.86e-06
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 2.41e-01 4.20e-01 0.17900 -0.164000 -0.072700 1.21e-01 4.91e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 4.83e-01 6.67e-01 0.17900 -0.099900 -0.148000 4.18e-01 2.29e-01
INFLAMMASOMES 18 4.48e-01 6.41e-01 0.17800 -0.161000 -0.075900 2.37e-01 5.77e-01
DAP12 INTERACTIONS 30 6.96e-03 3.33e-02 0.17800 -0.157000 0.083700 1.37e-01 4.28e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 352 3.84e-05 5.86e-04 0.17800 -0.140000 -0.110000 6.88e-06 4.21e-04
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 38 4.46e-03 2.43e-02 0.17800 -0.048800 0.171000 6.03e-01 6.85e-02
HDR THROUGH MMEJ ALT NHEJ 10 4.12e-01 6.05e-01 0.17800 -0.016500 -0.177000 9.28e-01 3.33e-01
METAL ION SLC TRANSPORTERS 25 3.67e-01 5.57e-01 0.17800 0.083400 0.157000 4.70e-01 1.75e-01
RHO GTPASES ACTIVATE FORMINS 118 3.02e-02 1.01e-01 0.17700 -0.108000 -0.141000 4.33e-02 8.21e-03
RHOBTB1 GTPASE CYCLE 23 2.91e-01 4.77e-01 0.17700 -0.060700 -0.166000 6.14e-01 1.67e-01
L1CAM INTERACTIONS 107 5.36e-02 1.54e-01 0.17700 0.132000 0.118000 1.87e-02 3.47e-02
LATE ENDOSOMAL MICROAUTOPHAGY 32 2.11e-01 3.83e-01 0.17700 -0.163000 -0.068000 1.10e-01 5.06e-01
HDACS DEACETYLATE HISTONES 45 9.49e-02 2.22e-01 0.17700 0.062100 0.165000 4.71e-01 5.51e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 4.05e-01 5.97e-01 0.17600 0.092300 0.150000 4.15e-01 1.85e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 4.60e-01 6.49e-01 0.17500 0.129000 0.119000 2.29e-01 2.69e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 2.17e-01 3.92e-01 0.17500 0.133000 0.114000 8.59e-02 1.39e-01
SARS COV 2 INFECTION 65 1.97e-03 1.26e-02 0.17500 -0.175000 -0.004160 1.48e-02 9.54e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 1.22e-01 2.59e-01 0.17400 0.161000 -0.067100 2.97e-01 6.64e-01
NEURONAL SYSTEM 373 6.95e-05 9.09e-04 0.17400 0.123000 0.123000 4.65e-05 4.55e-05
SHC1 EVENTS IN EGFR SIGNALING 11 6.02e-01 7.61e-01 0.17400 -0.160000 -0.067900 3.59e-01 6.97e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 70 3.35e-02 1.10e-01 0.17400 0.064000 0.161000 3.55e-01 1.97e-02
CTLA4 INHIBITORY SIGNALING 20 4.55e-01 6.46e-01 0.17300 -0.154000 -0.079400 2.33e-01 5.39e-01
PRC2 METHYLATES HISTONES AND DNA 28 7.20e-02 1.85e-01 0.17300 -0.173000 -0.004640 1.12e-01 9.66e-01
CROSSLINKING OF COLLAGEN FIBRILS 16 2.03e-01 3.71e-01 0.17300 0.173000 -0.002730 2.31e-01 9.85e-01
RHO GTPASES ACTIVATE IQGAPS 24 5.37e-01 7.15e-01 0.17300 -0.119000 -0.125000 3.13e-01 2.88e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 290 6.05e-04 5.08e-03 0.17300 -0.126000 -0.118000 2.19e-04 5.72e-04
DEADENYLATION OF MRNA 25 3.19e-01 5.02e-01 0.17300 -0.159000 -0.067300 1.69e-01 5.60e-01
MRNA SPLICING MINOR PATHWAY 52 2.58e-01 4.41e-01 0.17200 -0.129000 -0.115000 1.09e-01 1.53e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 603 1.57e-09 8.42e-08 0.17200 -0.149000 -0.086600 5.18e-10 2.94e-04
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 46 1.72e-01 3.33e-01 0.17100 -0.152000 -0.078800 7.41e-02 3.55e-01
EXTRACELLULAR MATRIX ORGANIZATION 247 1.58e-03 1.06e-02 0.17100 0.131000 0.110000 3.84e-04 2.96e-03
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 45 2.38e-02 8.52e-02 0.17100 0.015000 0.171000 8.62e-01 4.77e-02
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 64 4.24e-04 3.87e-03 0.17100 0.168000 -0.032800 2.02e-02 6.50e-01
G ALPHA Z SIGNALLING EVENTS 44 7.90e-04 6.06e-03 0.17100 -0.105000 0.134000 2.26e-01 1.23e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 2.51e-01 4.32e-01 0.17000 -0.162000 -0.053200 1.53e-01 6.39e-01
NICOTINATE METABOLISM 25 4.71e-01 6.56e-01 0.17000 -0.141000 -0.094900 2.22e-01 4.12e-01
GLUCONEOGENESIS 27 5.08e-01 6.90e-01 0.17000 -0.117000 -0.123000 2.91e-01 2.69e-01
GLYCOSAMINOGLYCAN METABOLISM 114 5.98e-03 2.93e-02 0.17000 0.065000 0.157000 2.31e-01 3.81e-03
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 5.62e-01 7.35e-01 0.16900 -0.161000 -0.053100 3.56e-01 7.60e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 6.17e-01 7.76e-01 0.16900 -0.144000 -0.088200 3.33e-01 5.54e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 3.79e-01 5.67e-01 0.16900 -0.157000 -0.062200 2.12e-01 6.22e-01
SENSORY PERCEPTION 149 2.59e-02 9.09e-02 0.16900 0.117000 0.122000 1.38e-02 1.03e-02
PURINE SALVAGE 12 6.98e-01 8.34e-01 0.16900 -0.141000 -0.093200 3.99e-01 5.76e-01
AMINE LIGAND BINDING RECEPTORS 28 2.73e-01 4.56e-01 0.16900 0.061600 0.157000 5.73e-01 1.50e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 3.00e-04 2.94e-03 0.16800 -0.032700 0.165000 6.38e-01 1.78e-02
DEADENYLATION DEPENDENT MRNA DECAY 55 2.55e-01 4.38e-01 0.16700 -0.127000 -0.109000 1.04e-01 1.63e-01
TRNA PROCESSING 105 6.29e-02 1.71e-01 0.16700 -0.101000 -0.133000 7.43e-02 1.87e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 5.02e-01 6.84e-01 0.16700 0.080100 0.146000 5.35e-01 2.58e-01
HIV TRANSCRIPTION ELONGATION 42 2.58e-01 4.41e-01 0.16600 -0.143000 -0.084400 1.08e-01 3.44e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 1.16e-01 2.51e-01 0.16600 0.161000 0.038300 9.37e-02 6.91e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 4.22e-02 1.31e-01 0.16600 -0.161000 0.041900 1.57e-01 7.11e-01
HCMV LATE EVENTS 64 5.64e-02 1.59e-01 0.16600 -0.154000 -0.060000 3.27e-02 4.07e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 9.74e-02 2.25e-01 0.16600 -0.086600 -0.141000 1.92e-01 3.36e-02
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 120 2.07e-04 2.29e-03 0.16500 0.023000 0.164000 6.64e-01 1.95e-03
METABOLISM OF NUCLEOTIDES 92 4.62e-02 1.39e-01 0.16500 -0.145000 -0.079800 1.66e-02 1.86e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 4.84e-01 6.68e-01 0.16500 -0.129000 -0.103000 2.31e-01 3.36e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 3.86e-02 1.22e-01 0.16500 0.016200 0.164000 8.54e-01 6.26e-02
RHO GTPASES ACTIVATE PKNS 46 1.79e-01 3.42e-01 0.16500 -0.148000 -0.072000 8.18e-02 3.99e-01
GAB1 SIGNALOSOME 14 5.67e-01 7.38e-01 0.16500 0.066200 0.151000 6.68e-01 3.29e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 1.94e-01 3.61e-01 0.16400 0.164000 0.012000 1.95e-01 9.24e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 4.37e-02 1.35e-01 0.16400 -0.164000 0.006010 9.84e-02 9.52e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 2.50e-01 4.30e-01 0.16400 0.163000 0.013100 2.31e-01 9.23e-01
CARGO CONCENTRATION IN THE ER 31 6.51e-02 1.74e-01 0.16400 -0.164000 0.001280 1.15e-01 9.90e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 29 4.35e-01 6.29e-01 0.16300 -0.088600 -0.137000 4.09e-01 2.01e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 48 2.27e-01 4.03e-01 0.16300 0.083100 0.141000 3.20e-01 9.22e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 3.06e-01 4.91e-01 0.16300 -0.042700 0.157000 8.15e-01 3.90e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 2.44e-02 8.67e-02 0.16300 -0.057500 0.152000 5.92e-01 1.56e-01
INTERLEUKIN 1 FAMILY SIGNALING 122 6.29e-02 1.71e-01 0.16200 -0.118000 -0.111000 2.47e-02 3.36e-02
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.60e-01 3.13e-01 0.16200 -0.132000 -0.093600 5.56e-02 1.76e-01
AMYLOID FIBER FORMATION 55 4.99e-03 2.64e-02 0.16200 -0.161000 0.014800 3.88e-02 8.50e-01
INTERLEUKIN 10 SIGNALING 19 6.15e-02 1.69e-01 0.16100 -0.111000 0.118000 4.04e-01 3.75e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 26 5.61e-01 7.35e-01 0.16000 -0.116000 -0.111000 3.07e-01 3.28e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 6.24e-01 7.78e-01 0.16000 -0.140000 -0.077300 3.48e-01 6.04e-01
NETRIN 1 SIGNALING 50 3.22e-01 5.05e-01 0.16000 0.105000 0.121000 2.01e-01 1.40e-01
MITOCHONDRIAL BIOGENESIS 93 9.84e-03 4.24e-02 0.16000 -0.045300 -0.153000 4.50e-01 1.07e-02
SIGNALING BY GPCR 483 8.60e-09 3.37e-07 0.16000 0.061800 0.147000 2.04e-02 3.25e-08
G ALPHA Q SIGNALLING EVENTS 157 7.67e-05 9.70e-04 0.15900 0.028400 0.156000 5.40e-01 7.40e-04
REGULATION OF BETA CELL DEVELOPMENT 29 1.51e-01 3.04e-01 0.15800 0.021900 0.157000 8.38e-01 1.44e-01
RNA POLYMERASE I TRANSCRIPTION 66 2.60e-02 9.10e-02 0.15800 -0.154000 -0.035400 3.02e-02 6.19e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 4.43e-01 6.39e-01 0.15800 0.146000 0.061200 2.47e-01 6.27e-01
TOLL LIKE RECEPTOR CASCADES 141 3.71e-02 1.19e-01 0.15800 -0.125000 -0.096500 1.04e-02 4.82e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT 195 2.68e-03 1.63e-02 0.15800 0.076300 0.138000 6.65e-02 8.89e-04
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 5.76e-01 7.41e-01 0.15700 -0.152000 -0.041800 3.84e-01 8.10e-01
NEUTROPHIL DEGRANULATION 393 5.29e-08 1.88e-06 0.15700 -0.148000 -0.051800 4.82e-07 7.88e-02
ACTIVATION OF MATRIX METALLOPROTEINASES 14 6.96e-01 8.34e-01 0.15700 -0.131000 -0.086800 3.97e-01 5.74e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 8.75e-02 2.11e-01 0.15700 0.098800 0.122000 7.49e-02 2.83e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 3.54e-01 5.40e-01 0.15600 -0.144000 -0.061600 1.89e-01 5.73e-01
MITOTIC PROMETAPHASE 176 8.59e-04 6.48e-03 0.15600 -0.055600 -0.146000 2.04e-01 8.59e-04
MTOR SIGNALLING 41 4.20e-01 6.12e-01 0.15600 -0.114000 -0.106000 2.06e-01 2.39e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 5.67e-01 7.38e-01 0.15600 0.050400 0.148000 7.53e-01 3.57e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 5.09e-01 6.90e-01 0.15600 0.145000 0.056200 3.01e-01 6.88e-01
EXTENSION OF TELOMERES 49 2.87e-01 4.71e-01 0.15500 -0.130000 -0.085600 1.16e-01 3.00e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 5.72e-01 7.40e-01 0.15400 -0.113000 -0.105000 3.09e-01 3.45e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 1.02e-01 2.34e-01 0.15400 0.098400 0.119000 7.88e-02 3.43e-02
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 6.58e-01 8.06e-01 0.15400 0.050900 0.145000 7.81e-01 4.26e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 5.69e-01 7.38e-01 0.15400 0.142000 0.057800 3.39e-01 6.98e-01
SIGNALING BY EGFR 47 3.01e-01 4.86e-01 0.15400 0.082800 0.129000 3.26e-01 1.25e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 95 1.16e-03 8.34e-03 0.15300 0.006930 0.153000 9.07e-01 9.92e-03
TRANSCRIPTIONAL REGULATION BY E2F6 34 7.05e-02 1.83e-01 0.15300 0.002410 -0.153000 9.81e-01 1.22e-01
GPCR LIGAND BINDING 268 2.71e-07 8.03e-06 0.15200 0.025700 0.150000 4.70e-01 2.34e-05
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 6.69e-01 8.14e-01 0.15200 0.107000 0.109000 4.07e-01 4.01e-01
PLATELET AGGREGATION PLUG FORMATION 32 5.27e-01 7.06e-01 0.15200 0.107000 0.108000 2.95e-01 2.89e-01
PLATELET SENSITIZATION BY LDL 15 4.55e-01 6.46e-01 0.15200 -0.149000 -0.031900 3.19e-01 8.30e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 62 1.11e-01 2.45e-01 0.15200 -0.140000 -0.059100 5.69e-02 4.21e-01
STIMULI SENSING CHANNELS 76 1.10e-01 2.44e-01 0.15100 0.134000 0.071000 4.41e-02 2.85e-01
BASE EXCISION REPAIR AP SITE FORMATION 28 1.02e-01 2.34e-01 0.15100 -0.151000 0.009940 1.67e-01 9.27e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 27 3.00e-01 4.86e-01 0.15100 -0.145000 -0.042700 1.93e-01 7.01e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 245 3.67e-03 2.10e-02 0.15000 0.085100 0.124000 2.20e-02 8.37e-04
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 7.31e-01 8.54e-01 0.15000 -0.126000 -0.081200 4.32e-01 6.12e-01
GPVI MEDIATED ACTIVATION CASCADE 31 2.20e-01 3.94e-01 0.15000 -0.146000 -0.034500 1.61e-01 7.40e-01
ADHERENS JUNCTIONS INTERACTIONS 30 2.87e-01 4.71e-01 0.14900 0.045500 0.142000 6.67e-01 1.78e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 7.39e-01 8.60e-01 0.14900 -0.095000 -0.115000 5.24e-01 4.41e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 7.30e-01 8.54e-01 0.14900 0.118000 0.090900 4.28e-01 5.42e-01
PLATELET CALCIUM HOMEOSTASIS 25 5.33e-01 7.11e-01 0.14900 0.127000 0.077100 2.70e-01 5.05e-01
MHC CLASS II ANTIGEN PRESENTATION 101 6.43e-02 1.73e-01 0.14900 -0.071500 -0.130000 2.15e-01 2.38e-02
DEATH RECEPTOR SIGNALLING 133 5.59e-02 1.59e-01 0.14800 0.086300 0.121000 8.58e-02 1.64e-02
INTERLEUKIN 17 SIGNALING 68 2.66e-01 4.50e-01 0.14800 -0.112000 -0.096600 1.09e-01 1.68e-01
COLLAGEN FORMATION 81 1.32e-03 9.20e-03 0.14800 0.147000 -0.016000 2.25e-02 8.04e-01
ONCOGENIC MAPK SIGNALING 76 1.05e-01 2.36e-01 0.14700 0.064500 0.132000 3.31e-01 4.60e-02
RESOLUTION OF ABASIC SITES AP SITES 37 3.13e-01 4.96e-01 0.14700 -0.134000 -0.060600 1.59e-01 5.23e-01
LONG TERM POTENTIATION 23 3.70e-01 5.58e-01 0.14700 0.141000 0.039800 2.41e-01 7.41e-01
CA DEPENDENT EVENTS 36 5.12e-01 6.92e-01 0.14700 0.105000 0.102000 2.75e-01 2.88e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 187 2.65e-04 2.76e-03 0.14700 0.037600 0.142000 3.76e-01 8.45e-04
AQUAPORIN MEDIATED TRANSPORT 42 6.60e-03 3.17e-02 0.14600 -0.096100 0.110000 2.81e-01 2.19e-01
ATTENUATION PHASE 24 7.46e-02 1.90e-01 0.14500 0.063600 -0.130000 5.90e-01 2.69e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 3.15e-01 4.99e-01 0.14400 -0.114000 -0.088500 1.29e-01 2.40e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 1.16e-02 4.82e-02 0.14400 -0.135000 0.052200 1.22e-01 5.49e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 31 3.08e-02 1.03e-01 0.14400 -0.075500 0.123000 4.67e-01 2.35e-01
IRS MEDIATED SIGNALLING 40 4.09e-01 6.02e-01 0.14400 -0.077800 -0.121000 3.94e-01 1.85e-01
OTHER INTERLEUKIN SIGNALING 20 6.31e-01 7.81e-01 0.14400 0.076000 0.122000 5.57e-01 3.44e-01
PROTEIN FOLDING 89 9.11e-02 2.16e-01 0.14400 -0.128000 -0.065800 3.73e-02 2.84e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 79 3.98e-04 3.69e-03 0.14400 0.050000 -0.135000 4.42e-01 3.86e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 90 7.24e-04 5.76e-03 0.14400 -0.019800 0.142000 7.46e-01 1.97e-02
O LINKED GLYCOSYLATION 86 2.01e-01 3.69e-01 0.14300 0.111000 0.090500 7.53e-02 1.47e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 6.99e-01 8.35e-01 0.14300 0.118000 0.079900 3.99e-01 5.68e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 61 3.21e-01 5.04e-01 0.14300 -0.111000 -0.089500 1.34e-01 2.27e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 5.60e-01 7.35e-01 0.14200 -0.070900 -0.124000 5.48e-01 2.95e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 1.66e-05 3.14e-04 0.14200 -0.136000 -0.041000 7.71e-05 2.34e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 4.44e-01 6.39e-01 0.14200 -0.140000 -0.022400 3.31e-01 8.77e-01
PEPTIDE LIGAND BINDING RECEPTORS 111 3.90e-03 2.19e-02 0.14200 0.022700 0.140000 6.80e-01 1.09e-02
FOXO MEDIATED TRANSCRIPTION 59 1.74e-03 1.13e-02 0.14200 -0.121000 0.073400 1.07e-01 3.30e-01
RHO GTPASE CYCLE 426 7.20e-04 5.76e-03 0.14200 0.102000 0.098200 3.08e-04 5.24e-04
EPHB MEDIATED FORWARD SIGNALING 42 3.23e-01 5.05e-01 0.14100 -0.127000 -0.063000 1.56e-01 4.80e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 18 6.27e-01 7.79e-01 0.14100 -0.125000 -0.065200 3.57e-01 6.32e-01
REGULATION OF IFNG SIGNALING 13 5.92e-01 7.52e-01 0.14100 -0.136000 -0.037900 3.96e-01 8.13e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 53 5.70e-03 2.85e-02 0.14100 0.052600 -0.131000 5.08e-01 9.93e-02
INNATE IMMUNE SYSTEM 790 9.28e-11 7.79e-09 0.14100 -0.130000 -0.054800 6.68e-10 9.19e-03
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 1.16e-01 2.51e-01 0.14100 -0.128000 -0.057300 5.61e-02 3.94e-01
PYRIMIDINE SALVAGE 10 8.15e-01 9.09e-01 0.13900 0.077000 0.116000 6.73e-01 5.24e-01
NEGATIVE REGULATION OF FLT3 14 7.29e-01 8.54e-01 0.13900 0.120000 0.070400 4.37e-01 6.48e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 2.08e-01 3.79e-01 0.13900 0.102000 0.094400 8.79e-02 1.14e-01
SNRNP ASSEMBLY 51 3.11e-01 4.95e-01 0.13800 -0.120000 -0.068600 1.38e-01 3.97e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 7.30e-01 8.54e-01 0.13800 -0.065100 -0.122000 6.85e-01 4.47e-01
AUTOPHAGY 140 4.97e-02 1.46e-01 0.13800 -0.118000 -0.071200 1.61e-02 1.46e-01
DNA REPAIR 288 6.61e-03 3.17e-02 0.13700 -0.109000 -0.083800 1.56e-03 1.46e-02
VISUAL PHOTOTRANSDUCTION 59 6.83e-02 1.80e-01 0.13700 0.024000 0.135000 7.50e-01 7.33e-02
P75NTR SIGNALS VIA NF KB 16 6.38e-01 7.86e-01 0.13700 0.125000 0.054700 3.86e-01 7.05e-01
HYALURONAN UPTAKE AND DEGRADATION 11 7.67e-01 8.80e-01 0.13700 0.063500 0.121000 7.15e-01 4.87e-01
SYNDECAN INTERACTIONS 26 5.31e-01 7.09e-01 0.13600 0.061900 0.121000 5.85e-01 2.85e-01
SIGNALING BY FGFR4 IN DISEASE 11 5.12e-01 6.92e-01 0.13600 -0.136000 0.001100 4.35e-01 9.95e-01
KERATAN SULFATE BIOSYNTHESIS 24 8.57e-02 2.07e-01 0.13600 -0.081900 0.108000 4.88e-01 3.58e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 6.85e-01 8.26e-01 0.13500 0.041100 0.129000 8.14e-01 4.58e-01
DISEASES OF METABOLISM 198 3.39e-02 1.10e-01 0.13500 0.107000 0.082800 9.39e-03 4.48e-02
SIGNALING BY NODAL 15 2.31e-01 4.08e-01 0.13500 -0.069300 0.116000 6.42e-01 4.37e-01
SIGNALING BY BMP 25 1.02e-01 2.34e-01 0.13500 -0.054500 0.124000 6.37e-01 2.85e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 108 5.61e-04 4.78e-03 0.13500 0.134000 -0.016200 1.62e-02 7.71e-01
ADAPTIVE IMMUNE SYSTEM 613 5.05e-05 7.24e-04 0.13500 -0.105000 -0.084700 9.70e-06 3.62e-04
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 86 6.81e-04 5.60e-03 0.13500 0.042400 -0.128000 4.97e-01 4.03e-02
INFECTIOUS DISEASE 734 7.08e-13 2.08e-10 0.13500 -0.131000 -0.030700 1.75e-09 1.58e-01
SIGNALING BY RETINOIC ACID 34 5.07e-01 6.90e-01 0.13400 -0.114000 -0.071400 2.50e-01 4.72e-01
DAP12 SIGNALING 24 9.10e-02 2.16e-01 0.13400 -0.079200 0.109000 5.02e-01 3.57e-01
DNA DOUBLE STRAND BREAK REPAIR 134 4.48e-02 1.37e-01 0.13400 -0.062100 -0.119000 2.15e-01 1.74e-02
INTRINSIC PATHWAY FOR APOPTOSIS 52 3.70e-01 5.58e-01 0.13400 -0.112000 -0.073000 1.62e-01 3.62e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 3.12e-01 4.96e-01 0.13400 -0.113000 0.072000 4.99e-01 6.66e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 6.92e-01 8.31e-01 0.13300 -0.092500 -0.095900 4.33e-01 4.16e-01
LYSINE CATABOLISM 11 3.46e-01 5.32e-01 0.13300 0.112000 -0.072400 5.21e-01 6.78e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 2.21e-01 3.95e-01 0.13200 -0.115000 -0.066000 9.08e-02 3.30e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 1.52e-01 3.04e-01 0.13200 -0.132000 0.003540 1.96e-01 9.72e-01
KILLING MECHANISMS 11 8.33e-01 9.21e-01 0.13200 0.079700 0.105000 6.47e-01 5.46e-01
GENERATION OF SECOND MESSENGER MOLECULES 19 7.03e-01 8.37e-01 0.13200 -0.110000 -0.071900 4.05e-01 5.88e-01
MYD88 INDEPENDENT TLR4 CASCADE 94 1.99e-01 3.68e-01 0.13200 -0.107000 -0.076300 7.26e-02 2.01e-01
ION CHANNEL TRANSPORT 142 8.79e-02 2.11e-01 0.13200 0.107000 0.076200 2.75e-02 1.17e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 6.63e-01 8.10e-01 0.13200 -0.030900 -0.128000 8.59e-01 4.63e-01
LYSOSOME VESICLE BIOGENESIS 33 6.09e-01 7.68e-01 0.13100 -0.097600 -0.087200 3.32e-01 3.86e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 176 5.90e-04 4.99e-03 0.13100 -0.129000 -0.021300 3.15e-03 6.27e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 6.21e-01 7.77e-01 0.13100 0.114000 0.064200 3.44e-01 5.94e-01
PLASMA LIPOPROTEIN CLEARANCE 27 6.74e-01 8.17e-01 0.13000 0.093300 0.090700 4.02e-01 4.15e-01
CD209 DC SIGN SIGNALING 18 3.63e-01 5.51e-01 0.13000 -0.130000 0.002060 3.39e-01 9.88e-01
POLO LIKE KINASE MEDIATED EVENTS 13 7.52e-01 8.68e-01 0.13000 -0.115000 -0.060000 4.71e-01 7.08e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 53 7.31e-03 3.43e-02 0.12900 -0.103000 0.077800 1.93e-01 3.27e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 1.61e-01 3.15e-01 0.12900 0.040200 0.122000 5.90e-01 1.01e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 3.21e-01 5.04e-01 0.12900 0.113000 -0.061500 4.80e-01 7.01e-01
RAP1 SIGNALLING 15 7.47e-01 8.66e-01 0.12900 -0.064900 -0.111000 6.63e-01 4.56e-01
SIGNALING BY NTRK2 TRKB 24 6.21e-01 7.77e-01 0.12800 0.062800 0.112000 5.95e-01 3.44e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 4.95e-03 2.63e-02 0.12800 0.015800 -0.127000 8.01e-01 4.34e-02
AURKA ACTIVATION BY TPX2 72 3.85e-03 2.18e-02 0.12800 0.042200 -0.121000 5.36e-01 7.71e-02
MITOCHONDRIAL TRNA AMINOACYLATION 21 7.02e-01 8.37e-01 0.12700 0.106000 0.071300 4.02e-01 5.72e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 4.96e-01 6.79e-01 0.12700 -0.096100 -0.083200 2.45e-01 3.14e-01
ACYL CHAIN REMODELLING OF PG 10 6.35e-01 7.84e-01 0.12700 -0.011700 -0.127000 9.49e-01 4.88e-01
ACYL CHAIN REMODELLING OF PS 14 7.97e-01 8.99e-01 0.12700 -0.104000 -0.073100 5.01e-01 6.36e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 3.53e-01 5.40e-01 0.12600 -0.116000 -0.047900 1.92e-01 5.91e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 9.24e-02 2.19e-01 0.12600 0.117000 -0.045700 2.60e-01 6.60e-01
SIGNALING BY ERYTHROPOIETIN 24 4.65e-01 6.52e-01 0.12600 0.033500 0.121000 7.76e-01 3.05e-01
INWARDLY RECTIFYING K CHANNELS 32 8.52e-02 2.07e-01 0.12500 -0.116000 0.046500 2.54e-01 6.49e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 550 2.45e-11 2.40e-09 0.12500 -0.125000 -0.008690 6.01e-07 7.28e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 92 2.86e-01 4.71e-01 0.12500 -0.083500 -0.092800 1.67e-01 1.24e-01
RHO GTPASES ACTIVATE PAKS 21 5.19e-01 6.98e-01 0.12500 0.120000 0.033600 3.41e-01 7.90e-01
RHO GTPASES ACTIVATE CIT 18 7.74e-01 8.84e-01 0.12400 0.097100 0.077800 4.76e-01 5.68e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 7.10e-02 1.83e-01 0.12400 0.124000 0.002140 1.14e-01 9.78e-01
ASSEMBLY OF THE HIV VIRION 16 7.80e-01 8.88e-01 0.12400 -0.102000 -0.071600 4.81e-01 6.20e-01
METABOLISM OF FOLATE AND PTERINES 15 2.71e-01 4.55e-01 0.12400 0.089000 -0.086500 5.51e-01 5.62e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 3.77e-01 5.66e-01 0.12400 -0.108000 0.060500 5.17e-01 7.17e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 6.76e-01 8.19e-01 0.12400 -0.108000 -0.060600 3.91e-01 6.31e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 3.17e-01 5.00e-01 0.12300 -0.083100 -0.091100 1.81e-01 1.42e-01
GROWTH HORMONE RECEPTOR SIGNALING 20 2.73e-01 4.56e-01 0.12200 -0.028900 0.119000 8.23e-01 3.59e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 7.14e-02 1.84e-01 0.12200 -0.107000 -0.057900 2.72e-02 2.34e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 7.47e-01 8.66e-01 0.12100 0.087800 0.083100 4.66e-01 4.90e-01
MYOGENESIS 25 7.30e-01 8.54e-01 0.12000 0.082700 0.087500 4.74e-01 4.49e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 6.15e-01 7.75e-01 0.12000 -0.078700 -0.090800 4.01e-01 3.33e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 6.51e-01 7.99e-01 0.12000 0.117000 0.029100 4.50e-01 8.50e-01
G ALPHA I SIGNALLING EVENTS 204 1.19e-03 8.35e-03 0.12000 0.024000 0.118000 5.56e-01 3.84e-03
KERATAN SULFATE KERATIN METABOLISM 30 1.09e-01 2.43e-01 0.12000 -0.052700 0.108000 6.18e-01 3.07e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 97 2.13e-03 1.36e-02 0.12000 0.116000 -0.030600 4.87e-02 6.03e-01
MRNA SPLICING 188 9.67e-02 2.24e-01 0.12000 -0.088600 -0.080600 3.64e-02 5.69e-02
MEIOSIS 63 1.66e-01 3.22e-01 0.11900 -0.115000 -0.032400 1.15e-01 6.57e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 2.42e-03 1.51e-02 0.11900 -0.118000 -0.019300 7.90e-03 6.63e-01
ACYL CHAIN REMODELLING OF PC 17 7.62e-01 8.77e-01 0.11900 0.102000 0.062400 4.68e-01 6.56e-01
KERATAN SULFATE DEGRADATION 11 8.74e-01 9.46e-01 0.11900 0.083200 0.085300 6.33e-01 6.24e-01
MAP2K AND MAPK ACTIVATION 36 4.51e-01 6.42e-01 0.11900 0.045800 0.110000 6.35e-01 2.53e-01
UB SPECIFIC PROCESSING PROTEASES 169 1.06e-01 2.39e-01 0.11900 -0.094400 -0.072200 3.44e-02 1.06e-01
TIE2 SIGNALING 17 7.26e-01 8.54e-01 0.11800 -0.106000 -0.053100 4.50e-01 7.05e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 4.97e-01 6.80e-01 0.11800 -0.116000 -0.022100 3.57e-01 8.61e-01
HEME SIGNALING 45 1.45e-01 2.98e-01 0.11800 0.118000 0.004620 1.70e-01 9.57e-01
MEIOTIC SYNAPSIS 40 1.30e-01 2.73e-01 0.11800 -0.118000 0.010100 1.98e-01 9.12e-01
PREGNENOLONE BIOSYNTHESIS 12 7.31e-01 8.54e-01 0.11800 -0.035500 -0.112000 8.31e-01 5.01e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1223 6.05e-10 4.74e-08 0.11800 -0.105000 -0.052600 7.48e-10 2.13e-03
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 7.96e-01 8.98e-01 0.11700 -0.086300 -0.079600 5.15e-01 5.48e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.78e-01 3.40e-01 0.11700 -0.033600 -0.112000 6.40e-01 1.18e-01
CELLULAR RESPONSE TO HEAT STRESS 95 2.62e-01 4.45e-01 0.11700 -0.065500 -0.096900 2.70e-01 1.03e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 7.71e-01 8.83e-01 0.11700 -0.101000 -0.058200 4.83e-01 6.87e-01
COLLAGEN DEGRADATION 51 2.06e-02 7.55e-02 0.11700 0.074100 -0.090200 3.60e-01 2.65e-01
RHOBTB GTPASE CYCLE 35 6.25e-01 7.79e-01 0.11700 -0.068100 -0.094700 4.86e-01 3.33e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 7.34e-01 8.56e-01 0.11600 0.077700 0.086600 4.93e-01 4.45e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 7.68e-01 8.80e-01 0.11600 -0.074800 -0.088400 5.44e-01 4.73e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 6.88e-01 8.28e-01 0.11600 -0.115000 -0.010900 5.29e-01 9.53e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 6.61e-01 8.09e-01 0.11500 0.113000 0.020900 4.79e-01 8.96e-01
TRANSCRIPTIONAL REGULATION BY TP53 346 2.07e-02 7.57e-02 0.11500 -0.079300 -0.083000 1.14e-02 8.12e-03
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 8.52e-01 9.33e-01 0.11400 -0.090400 -0.070000 5.73e-01 6.62e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 1.32e-02 5.35e-02 0.11400 -0.114000 0.007150 5.66e-02 9.05e-01
ION HOMEOSTASIS 49 4.18e-01 6.11e-01 0.11400 0.103000 0.049900 2.14e-01 5.45e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 95 3.41e-01 5.28e-01 0.11400 -0.084700 -0.076100 1.54e-01 2.00e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 5.62e-01 7.35e-01 0.11400 0.042600 0.105000 6.96e-01 3.34e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 3.05e-01 4.91e-01 0.11400 -0.114000 0.000797 2.98e-01 9.94e-01
GABA RECEPTOR ACTIVATION 55 4.59e-02 1.39e-01 0.11300 -0.027400 0.110000 7.25e-01 1.59e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 3.78e-01 5.67e-01 0.11300 0.024500 0.110000 8.04e-01 2.65e-01
SMOOTH MUSCLE CONTRACTION 33 1.53e-01 3.05e-01 0.11200 0.108000 -0.030900 2.83e-01 7.58e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 7.32e-01 8.54e-01 0.11200 -0.048900 -0.101000 7.20e-01 4.58e-01
FGFR2 ALTERNATIVE SPLICING 25 7.62e-01 8.77e-01 0.11200 -0.079100 -0.079500 4.94e-01 4.92e-01
SELECTIVE AUTOPHAGY 73 4.58e-01 6.48e-01 0.11100 -0.080300 -0.077100 2.36e-01 2.55e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 2.20e-01 3.94e-01 0.11100 -0.039600 -0.104000 5.56e-01 1.23e-01
HEDGEHOG ON STATE 83 3.31e-01 5.16e-01 0.11100 -0.093500 -0.059400 1.41e-01 3.50e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 8.31e-02 2.05e-01 0.11100 -0.081000 -0.075200 3.20e-02 4.66e-02
TRANSCRIPTIONAL REGULATION BY VENTX 35 6.00e-01 7.59e-01 0.11000 0.054700 0.096000 5.76e-01 3.26e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 2.80e-01 4.63e-01 0.11000 -0.110000 0.000243 2.80e-01 9.98e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 8.07e-01 9.04e-01 0.11000 0.071500 0.083300 5.80e-01 5.19e-01
TBC RABGAPS 43 3.00e-01 4.86e-01 0.11000 -0.108000 -0.021600 2.23e-01 8.07e-01
PHOSPHOLIPID METABOLISM 187 1.18e-01 2.55e-01 0.11000 0.065900 0.087700 1.21e-01 3.89e-02
DEUBIQUITINATION 243 6.50e-02 1.74e-01 0.11000 -0.087200 -0.066400 1.95e-02 7.53e-02
RHO GTPASES ACTIVATE ROCKS 19 2.86e-01 4.71e-01 0.10900 0.088900 -0.063600 5.03e-01 6.31e-01
DISEASES OF DNA REPAIR 11 5.96e-01 7.55e-01 0.10900 0.108000 -0.016100 5.35e-01 9.26e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 7.08e-01 8.40e-01 0.10900 -0.082000 -0.071300 4.15e-01 4.78e-01
FORMATION OF THE CORNIFIED ENVELOPE 26 4.48e-01 6.41e-01 0.10800 0.014500 0.108000 8.99e-01 3.43e-01
KERATINIZATION 26 4.48e-01 6.41e-01 0.10800 0.014500 0.108000 8.99e-01 3.43e-01
TRP CHANNELS 20 8.11e-01 9.08e-01 0.10800 0.070500 0.082300 5.85e-01 5.24e-01
PTEN REGULATION 136 1.51e-01 3.04e-01 0.10800 -0.094000 -0.053700 5.87e-02 2.80e-01
COMPLEMENT CASCADE 27 7.61e-01 8.77e-01 0.10700 0.080700 0.069500 4.68e-01 5.32e-01
SIGNALING BY MET 74 3.90e-01 5.80e-01 0.10600 0.090500 0.054500 1.78e-01 4.18e-01
PEPTIDE HORMONE METABOLISM 59 7.36e-02 1.88e-01 0.10600 -0.104000 0.016100 1.66e-01 8.30e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 2.57e-02 9.05e-02 0.10500 -0.093500 0.047900 1.96e-01 5.08e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 5.85e-01 7.46e-01 0.10500 -0.010800 0.104000 9.46e-01 5.15e-01
POTASSIUM CHANNELS 91 4.16e-01 6.09e-01 0.10500 0.068900 0.078700 2.56e-01 1.95e-01
RHO GTPASE EFFECTORS 250 9.05e-02 2.16e-01 0.10400 -0.067200 -0.079600 6.76e-02 3.05e-02
SIGNALING BY FGFR IN DISEASE 57 5.82e-01 7.44e-01 0.10400 -0.077500 -0.069300 3.11e-01 3.66e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 7.76e-01 8.86e-01 0.10300 0.048500 0.090600 7.14e-01 4.94e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 140 3.03e-03 1.79e-02 0.10300 -0.102000 0.015100 3.81e-02 7.57e-01
IRAK1 RECRUITS IKK COMPLEX 14 8.57e-01 9.35e-01 0.10300 0.085300 0.056900 5.81e-01 7.12e-01
INTERLEUKIN 27 SIGNALING 10 8.57e-01 9.35e-01 0.10200 0.041700 0.093300 8.19e-01 6.09e-01
SIGNALLING TO RAS 20 7.48e-01 8.66e-01 0.10200 0.044000 0.092100 7.33e-01 4.76e-01
HSF1 DEPENDENT TRANSACTIVATION 34 1.36e-01 2.83e-01 0.10200 0.076000 -0.068200 4.43e-01 4.91e-01
ESR MEDIATED SIGNALING 166 6.43e-04 5.32e-03 0.10200 -0.099500 0.022600 2.71e-02 6.16e-01
INSULIN RECEPTOR SIGNALLING CASCADE 45 6.35e-01 7.84e-01 0.10200 -0.060500 -0.082100 4.83e-01 3.41e-01
RHOH GTPASE CYCLE 37 2.72e-01 4.56e-01 0.10100 -0.101000 0.004210 2.88e-01 9.65e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 2.60e-01 4.43e-01 0.10100 -0.043300 0.091000 7.02e-01 4.22e-01
JOSEPHIN DOMAIN DUBS 11 8.17e-01 9.11e-01 0.10000 -0.031800 -0.095300 8.55e-01 5.84e-01
SIGNALING BY INTERLEUKINS 351 1.88e-03 1.21e-02 0.10000 -0.095000 -0.031700 2.28e-03 3.08e-01
SIGNALING BY WNT 266 4.85e-05 7.14e-04 0.10000 -0.099500 0.011000 5.27e-03 7.57e-01
RNA POLYMERASE II TRANSCRIPTION 1097 7.50e-05 9.59e-04 0.09970 -0.078200 -0.061800 1.40e-05 5.98e-04
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 8.00e-01 9.01e-01 0.09950 0.068600 0.072000 5.45e-01 5.25e-01
SIGNALING BY FGFR1 44 6.37e-01 7.86e-01 0.09930 -0.082400 -0.055400 3.45e-01 5.25e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 6.78e-01 8.20e-01 0.09920 -0.008990 -0.098700 9.54e-01 5.22e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 183 1.31e-01 2.75e-01 0.09910 0.051200 0.084900 2.33e-01 4.79e-02
THE PHOTOTRANSDUCTION CASCADE 21 7.23e-01 8.52e-01 0.09770 0.036000 0.090800 7.75e-01 4.71e-01
RHOJ GTPASE CYCLE 55 6.16e-01 7.76e-01 0.09730 0.076500 0.060100 3.26e-01 4.41e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 7.22e-01 8.52e-01 0.09730 -0.083500 -0.049900 4.29e-01 6.36e-01
SIGNALING BY ERBB2 48 6.68e-01 8.14e-01 0.09700 -0.073900 -0.062800 3.76e-01 4.52e-01
P38MAPK EVENTS 13 7.89e-01 8.93e-01 0.09660 -0.092600 -0.027400 5.63e-01 8.64e-01
CELL CELL COMMUNICATION 107 1.20e-01 2.57e-01 0.09620 0.022900 0.093500 6.82e-01 9.50e-02
SIGNALING BY FGFR2 64 5.76e-01 7.41e-01 0.09600 -0.058900 -0.075800 4.16e-01 2.94e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 5.13e-01 6.92e-01 0.09570 0.018400 0.094000 8.59e-01 3.65e-01
PARASITE INFECTION 54 2.97e-01 4.82e-01 0.09530 -0.094000 -0.015500 2.32e-01 8.43e-01
OPIOID SIGNALLING 86 1.08e-01 2.42e-01 0.09480 0.007120 0.094500 9.09e-01 1.30e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 96 4.65e-01 6.52e-01 0.09460 -0.072100 -0.061200 2.22e-01 3.00e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 6.86e-01 8.26e-01 0.09460 -0.086700 -0.037700 4.27e-01 7.30e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 8.96e-01 9.59e-01 0.09450 -0.078000 -0.053300 6.40e-01 7.49e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 105 6.28e-03 3.06e-02 0.09450 -0.079200 0.051500 1.61e-01 3.63e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 6.72e-01 8.16e-01 0.09420 -0.009080 -0.093800 9.50e-01 5.16e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 78 2.18e-02 7.88e-02 0.09350 -0.062900 0.069100 3.37e-01 2.91e-01
HCMV INFECTION 102 2.42e-01 4.22e-01 0.09300 -0.086400 -0.034300 1.32e-01 5.50e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 5.56e-01 7.31e-01 0.09210 -0.034000 -0.085600 7.00e-01 3.32e-01
HS GAG BIOSYNTHESIS 30 5.55e-01 7.31e-01 0.09210 0.018500 0.090200 8.61e-01 3.93e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 7.80e-01 8.88e-01 0.09170 -0.011100 -0.091000 9.49e-01 6.01e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 4.51e-01 6.42e-01 0.09160 -0.076200 -0.050800 2.09e-01 4.03e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.98e-01 3.66e-01 0.09100 -0.070500 0.057500 4.71e-01 5.56e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 16 8.69e-01 9.44e-01 0.09080 0.049800 0.075900 7.30e-01 5.99e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.03e-01 2.35e-01 0.09060 -0.000254 0.090600 9.97e-01 1.49e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 16 4.82e-01 6.67e-01 0.09000 0.059200 -0.067800 6.82e-01 6.39e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 74 5.91e-01 7.52e-01 0.08980 -0.059400 -0.067400 3.77e-01 3.17e-01
ZINC TRANSPORTERS 16 8.04e-01 9.02e-01 0.08950 0.030900 0.084000 8.30e-01 5.61e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 6.96e-01 8.34e-01 0.08920 -0.053900 -0.071000 5.18e-01 3.95e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 6.83e-01 8.24e-01 0.08910 0.086400 -0.021500 6.20e-01 9.02e-01
SIGNALING BY NTRKS 130 4.76e-03 2.56e-02 0.08840 -0.076900 0.043500 1.30e-01 3.92e-01
PROLACTIN RECEPTOR SIGNALING 11 6.18e-01 7.76e-01 0.08820 -0.066700 0.057700 7.02e-01 7.40e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 8.38e-01 9.25e-01 0.08820 -0.018400 -0.086200 9.20e-01 6.37e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 9.03e-01 9.62e-01 0.08810 0.069800 0.053800 6.51e-01 7.27e-01
SARS COV INFECTIONS 140 9.59e-03 4.16e-02 0.08800 -0.085700 0.020100 8.04e-02 6.82e-01
PLATELET HOMEOSTASIS 77 8.06e-02 2.01e-01 0.08780 -0.018800 0.085800 7.75e-01 1.93e-01
CIRCADIAN CLOCK 68 4.13e-01 6.06e-01 0.08750 0.030200 0.082100 6.67e-01 2.42e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 5.17e-01 6.96e-01 0.08700 0.021000 0.084400 8.16e-01 3.50e-01
APOPTOTIC EXECUTION PHASE 45 4.78e-01 6.64e-01 0.08680 -0.084500 -0.020100 3.27e-01 8.15e-01
MUSCLE CONTRACTION 162 2.71e-01 4.55e-01 0.08630 0.072900 0.046300 1.10e-01 3.10e-01
HATS ACETYLATE HISTONES 92 4.58e-01 6.48e-01 0.08600 0.044000 0.073900 4.66e-01 2.21e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 7.43e-01 8.64e-01 0.08590 -0.007250 0.085500 9.67e-01 6.23e-01
SIGNAL TRANSDUCTION BY L1 21 5.64e-01 7.36e-01 0.08580 -0.085400 0.008100 4.98e-01 9.49e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 4.46e-01 6.40e-01 0.08470 -0.062700 0.056900 6.27e-01 6.59e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 147 1.24e-01 2.63e-01 0.08390 -0.080900 -0.022300 9.07e-02 6.41e-01
SIGNALING BY SCF KIT 41 6.81e-01 8.23e-01 0.08390 0.037700 0.074900 6.76e-01 4.07e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 8.48e-01 9.32e-01 0.08340 0.029000 0.078200 8.51e-01 6.12e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 9.33e-01 9.73e-01 0.08340 -0.052600 -0.064600 7.62e-01 7.10e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 1.89e-02 7.18e-02 0.08330 -0.061200 0.056500 2.86e-01 3.25e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 7.19e-01 8.51e-01 0.08300 0.071100 0.042900 4.26e-01 6.31e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.12e-01 4.95e-01 0.08290 -0.001420 0.082800 9.86e-01 3.06e-01
SODIUM CALCIUM EXCHANGERS 10 7.12e-01 8.44e-01 0.08260 -0.032200 0.076000 8.60e-01 6.77e-01
SIGNALING BY NUCLEAR RECEPTORS 224 2.92e-04 2.91e-03 0.08250 -0.069800 0.043800 7.21e-02 2.59e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 6.31e-01 7.81e-01 0.08240 -0.080500 0.017400 5.77e-01 9.04e-01
SIGNALING BY NOTCH 187 3.25e-03 1.89e-02 0.08240 -0.023500 0.078900 5.81e-01 6.29e-02
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 46 5.49e-01 7.26e-01 0.08230 -0.023900 -0.078800 7.79e-01 3.55e-01
TRNA AMINOACYLATION 42 4.72e-01 6.56e-01 0.08230 -0.010600 -0.081600 9.06e-01 3.60e-01
O LINKED GLYCOSYLATION OF MUCINS 40 2.18e-01 3.93e-01 0.08220 -0.056900 0.059300 5.34e-01 5.16e-01
SLC TRANSPORTER DISORDERS 77 3.72e-01 5.61e-01 0.08210 0.024100 0.078400 7.15e-01 2.34e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 7.23e-01 8.52e-01 0.08190 -0.080900 0.013300 6.28e-01 9.37e-01
CARDIAC CONDUCTION 107 5.43e-01 7.20e-01 0.08150 0.057200 0.058100 3.07e-01 3.00e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 7.82e-01 8.89e-01 0.08130 0.037900 0.072000 7.24e-01 5.02e-01
MICRORNA MIRNA BIOGENESIS 24 8.70e-01 9.44e-01 0.08120 0.060900 0.053800 6.06e-01 6.49e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 93 8.16e-02 2.02e-01 0.08110 -0.014900 0.079700 8.04e-01 1.84e-01
NUCLEAR SIGNALING BY ERBB4 31 5.93e-01 7.52e-01 0.08100 0.011700 0.080200 9.10e-01 4.40e-01
LEISHMANIA INFECTION 199 3.73e-03 2.12e-02 0.08090 -0.018900 0.078600 6.45e-01 5.62e-02
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 9.14e-01 9.67e-01 0.07990 0.059600 0.053100 6.80e-01 7.13e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 5.12e-01 6.92e-01 0.07970 -0.075800 -0.024500 3.22e-01 7.49e-01
DSCAM INTERACTIONS 11 7.32e-01 8.54e-01 0.07960 0.020900 -0.076900 9.05e-01 6.59e-01
VLDLR INTERNALISATION AND DEGRADATION 12 7.02e-01 8.37e-01 0.07950 0.075600 -0.024700 6.50e-01 8.82e-01
SIGNALING BY FGFR 75 6.53e-01 8.01e-01 0.07930 -0.061100 -0.050600 3.61e-01 4.49e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 9.29e-01 9.72e-01 0.07890 -0.064000 -0.046200 7.01e-01 7.82e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 8.21e-01 9.14e-01 0.07890 -0.077700 -0.013700 6.28e-01 9.32e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 8.66e-01 9.43e-01 0.07840 -0.050500 -0.059900 6.56e-01 5.97e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 4.89e-01 6.73e-01 0.07830 -0.077300 -0.012800 3.60e-01 8.79e-01
RAB REGULATION OF TRAFFICKING 118 4.56e-01 6.46e-01 0.07830 -0.066100 -0.041800 2.15e-01 4.33e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 24 5.35e-01 7.13e-01 0.07800 -0.076100 0.017200 5.19e-01 8.84e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.78e-01 7.42e-01 0.07800 -0.025600 0.073700 8.47e-01 5.78e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 60 3.05e-01 4.90e-01 0.07800 -0.078000 0.000171 2.96e-01 9.98e-01
SIGNALING BY FGFR1 IN DISEASE 33 8.12e-01 9.08e-01 0.07780 0.043400 0.064600 6.67e-01 5.21e-01
REGULATED PROTEOLYSIS OF P75NTR 12 9.23e-01 9.70e-01 0.07770 0.065800 0.041300 6.93e-01 8.04e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 61 2.28e-01 4.03e-01 0.07770 -0.076600 0.012800 3.01e-01 8.63e-01
BASIGIN INTERACTIONS 22 4.80e-01 6.66e-01 0.07710 -0.049800 0.058800 6.86e-01 6.33e-01
SIGNALING BY PDGF 57 6.70e-01 8.14e-01 0.07690 0.066700 0.038300 3.84e-01 6.18e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 4.22e-01 6.13e-01 0.07660 -0.063800 0.042300 5.66e-01 7.04e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 7.63e-01 8.77e-01 0.07630 -0.072700 0.023200 6.91e-01 8.99e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 9.28e-01 9.72e-01 0.07590 -0.055100 -0.052200 7.12e-01 7.26e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 221 8.82e-04 6.61e-03 0.07560 -0.056100 0.050700 1.51e-01 1.95e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 8.43e-01 9.29e-01 0.07520 -0.053100 -0.053200 5.87e-01 5.86e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 36 6.23e-01 7.78e-01 0.07520 -0.014800 -0.073700 8.78e-01 4.44e-01
CELL CELL JUNCTION ORGANIZATION 49 2.69e-01 4.53e-01 0.07520 -0.070900 0.025000 3.91e-01 7.62e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 4.28e-01 6.20e-01 0.07480 0.073300 -0.015300 4.47e-01 8.74e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 8.79e-01 9.48e-01 0.07460 -0.071500 -0.021400 6.68e-01 8.98e-01
ENDOGENOUS STEROLS 20 6.95e-01 8.34e-01 0.07390 0.073900 -0.001230 5.67e-01 9.92e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 3.85e-01 5.75e-01 0.07390 -0.072800 -0.012900 2.86e-01 8.50e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 179 5.26e-03 2.67e-02 0.07380 -0.039900 0.062200 3.58e-01 1.52e-01
RHOD GTPASE CYCLE 51 7.64e-01 8.78e-01 0.07350 0.043300 0.059400 5.93e-01 4.63e-01
SIGNALLING TO ERKS 34 7.49e-01 8.66e-01 0.07320 -0.067800 -0.027600 4.94e-01 7.80e-01
RHOQ GTPASE CYCLE 59 1.98e-01 3.66e-01 0.07300 0.065400 -0.032600 3.85e-01 6.65e-01
DEVELOPMENTAL BIOLOGY 828 8.74e-05 1.08e-03 0.07290 0.016100 0.071100 4.35e-01 5.43e-04
CILIUM ASSEMBLY 193 1.35e-02 5.42e-02 0.07270 0.071000 -0.015700 8.93e-02 7.07e-01
REGULATION OF SIGNALING BY CBL 22 7.99e-01 9.00e-01 0.07270 0.021000 0.069600 8.65e-01 5.72e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 9.34e-01 9.73e-01 0.07250 0.059000 0.042200 7.13e-01 7.92e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 9.03e-01 9.62e-01 0.07210 -0.046900 -0.054700 7.04e-01 6.57e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 14 9.39e-01 9.76e-01 0.07150 0.053400 0.047600 7.30e-01 7.58e-01
VXPX CARGO TARGETING TO CILIUM 19 7.88e-01 8.93e-01 0.07150 0.070500 0.012300 5.95e-01 9.26e-01
VIRAL MESSENGER RNA SYNTHESIS 42 8.25e-01 9.16e-01 0.07100 -0.055000 -0.044800 5.37e-01 6.15e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 7.79e-01 8.88e-01 0.07080 -0.060100 -0.037400 4.85e-01 6.64e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 93 2.40e-01 4.18e-01 0.07050 -0.070500 -0.002210 2.41e-01 9.71e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.94e-01 9.58e-01 0.07040 0.066300 0.023900 6.79e-01 8.82e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 5.67e-01 7.38e-01 0.07000 -0.056700 0.041100 6.53e-01 7.45e-01
DISEASES OF IMMUNE SYSTEM 27 6.23e-01 7.78e-01 0.06960 0.005390 -0.069300 9.61e-01 5.33e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 286 7.72e-04 6.01e-03 0.06950 0.033300 -0.061000 3.34e-01 7.62e-02
SIGNALING BY TGFB FAMILY MEMBERS 97 1.53e-01 3.05e-01 0.06940 -0.068500 0.011500 2.44e-01 8.45e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 6.72e-01 8.16e-01 0.06910 -0.010500 0.068300 9.34e-01 5.88e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 7.46e-01 8.66e-01 0.06910 0.053800 -0.043400 7.58e-01 8.03e-01
SHC MEDIATED CASCADE FGFR4 12 8.14e-01 9.09e-01 0.06900 -0.068800 0.005110 6.80e-01 9.76e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 6.92e-01 8.31e-01 0.06770 -0.067600 0.003530 5.75e-01 9.77e-01
RAC3 GTPASE CYCLE 91 7.03e-01 8.37e-01 0.06710 0.047900 0.047000 4.30e-01 4.38e-01
TRIGLYCERIDE BIOSYNTHESIS 10 9.54e-01 9.84e-01 0.06690 -0.056000 -0.036700 7.59e-01 8.41e-01
REGULATION OF FZD BY UBIQUITINATION 19 8.26e-01 9.16e-01 0.06660 0.014100 0.065100 9.15e-01 6.23e-01
INTRAFLAGELLAR TRANSPORT 52 6.30e-01 7.81e-01 0.06630 0.063900 0.017700 4.25e-01 8.25e-01
GAP JUNCTION DEGRADATION 11 7.95e-01 8.98e-01 0.06600 -0.062100 0.022400 7.21e-01 8.98e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 8.83e-01 9.51e-01 0.06520 -0.046300 -0.045800 6.40e-01 6.44e-01
HEMOSTASIS 473 4.41e-03 2.41e-02 0.06480 0.006120 0.064500 8.20e-01 1.66e-02
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 628 1.04e-01 2.36e-01 0.06480 0.049200 0.042100 3.62e-02 7.26e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 5.83e-01 7.44e-01 0.06470 -0.049000 0.042200 6.84e-01 7.26e-01
ERBB2 REGULATES CELL MOTILITY 14 8.24e-01 9.16e-01 0.06460 0.000688 -0.064600 9.96e-01 6.75e-01
SIGNALING BY EGFR IN CANCER 22 7.22e-01 8.52e-01 0.06450 -0.064300 0.004140 6.01e-01 9.73e-01
CALNEXIN CALRETICULIN CYCLE 26 5.46e-01 7.24e-01 0.06430 -0.044000 0.046800 6.98e-01 6.79e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 8.79e-01 9.48e-01 0.06430 -0.016200 -0.062200 9.14e-01 6.77e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 8.04e-01 9.02e-01 0.06420 -0.044000 -0.046800 5.53e-01 5.27e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 8.25e-01 9.16e-01 0.06390 0.062300 -0.014000 7.20e-01 9.36e-01
OVARIAN TUMOR DOMAIN PROTEASES 37 4.63e-01 6.52e-01 0.06350 -0.056800 0.028400 5.50e-01 7.65e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 9.46e-01 9.82e-01 0.06340 0.043700 0.046000 7.62e-01 7.50e-01
CGMP EFFECTS 15 8.76e-01 9.48e-01 0.06270 0.013500 0.061200 9.28e-01 6.81e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 9.07e-01 9.64e-01 0.06230 0.043100 0.044900 6.88e-01 6.75e-01
METABOLISM OF LIPIDS 614 8.12e-02 2.02e-01 0.06190 -0.052500 -0.032800 2.69e-02 1.66e-01
SIGNALING BY ERBB4 57 4.69e-01 6.55e-01 0.06170 -0.003090 0.061600 9.68e-01 4.21e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 8.52e-01 9.33e-01 0.06140 -0.060900 -0.007800 6.73e-01 9.57e-01
AGGREPHAGY 35 4.95e-01 6.78e-01 0.06130 0.031300 -0.052700 7.49e-01 5.89e-01
RND1 GTPASE CYCLE 38 8.84e-01 9.51e-01 0.06060 0.045800 0.039700 6.25e-01 6.72e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 32 5.28e-01 7.06e-01 0.06050 -0.050200 0.033700 6.23e-01 7.42e-01
METABOLISM OF CARBOHYDRATES 260 1.08e-01 2.42e-01 0.06030 0.011100 0.059300 7.58e-01 1.00e-01
POTENTIAL THERAPEUTICS FOR SARS 77 4.02e-01 5.95e-01 0.05990 -0.000767 0.059900 9.91e-01 3.64e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 9.32e-01 9.73e-01 0.05900 0.022700 0.054400 8.87e-01 7.34e-01
MEMBRANE TRAFFICKING 581 1.54e-01 3.06e-01 0.05900 -0.047100 -0.035500 5.31e-02 1.45e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 8.33e-01 9.21e-01 0.05890 -0.017700 -0.056200 8.72e-01 6.07e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 85 2.11e-01 3.83e-01 0.05850 0.050000 -0.030300 4.25e-01 6.30e-01
SIGNALING BY HEDGEHOG 142 6.52e-01 8.00e-01 0.05830 0.037800 0.044400 4.37e-01 3.62e-01
CLATHRIN MEDIATED ENDOCYTOSIS 133 4.46e-01 6.40e-01 0.05830 -0.055200 -0.018700 2.72e-01 7.10e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 102 2.31e-01 4.08e-01 0.05780 -0.056200 0.013300 3.27e-01 8.17e-01
PI 3K CASCADE FGFR3 13 9.61e-01 9.84e-01 0.05660 0.034100 0.045200 8.31e-01 7.78e-01
VESICLE MEDIATED TRANSPORT 613 1.78e-01 3.40e-01 0.05650 -0.043800 -0.035800 6.52e-02 1.32e-01
SIGNALING BY KIT IN DISEASE 20 7.90e-01 8.94e-01 0.05610 -0.055800 0.005690 6.66e-01 9.65e-01
REPRODUCTION 76 5.81e-01 7.44e-01 0.05610 -0.054800 -0.011700 4.09e-01 8.60e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 9.04e-01 9.62e-01 0.05580 -0.021700 -0.051500 8.63e-01 6.83e-01
NERVOUS SYSTEM DEVELOPMENT 553 1.17e-02 4.87e-02 0.05560 0.006710 0.055200 7.88e-01 2.69e-02
PLATELET ADHESION TO EXPOSED COLLAGEN 12 8.24e-01 9.16e-01 0.05520 0.048100 -0.026900 7.73e-01 8.72e-01
SCAVENGING BY CLASS A RECEPTORS 14 8.66e-01 9.43e-01 0.05500 -0.055000 0.001580 7.22e-01 9.92e-01
GLYCOGEN STORAGE DISEASES 12 8.66e-01 9.43e-01 0.05500 -0.008120 0.054400 9.61e-01 7.44e-01
NUCLEAR ENVELOPE BREAKDOWN 49 4.85e-01 6.68e-01 0.05490 -0.050900 0.020500 5.38e-01 8.04e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 9.62e-01 9.84e-01 0.05430 0.042800 0.033500 7.82e-01 8.28e-01
PI 3K CASCADE FGFR4 12 8.78e-01 9.48e-01 0.05390 -0.005330 0.053600 9.75e-01 7.48e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 7.84e-01 8.90e-01 0.05340 -0.053400 0.000375 6.37e-01 9.97e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 8.82e-01 9.50e-01 0.05300 -0.037400 -0.037600 6.41e-01 6.40e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 8.88e-01 9.54e-01 0.05290 0.004800 0.052700 9.74e-01 7.24e-01
GLYCOGEN METABOLISM 25 9.28e-01 9.72e-01 0.05270 0.044200 0.028800 7.02e-01 8.03e-01
SIGNALING BY PDGFR IN DISEASE 20 8.51e-01 9.33e-01 0.05230 0.003230 0.052200 9.80e-01 6.86e-01
SPRY REGULATION OF FGF SIGNALING 16 8.52e-01 9.33e-01 0.05170 -0.051500 0.005190 7.21e-01 9.71e-01
METABOLISM OF STEROIDS 114 2.58e-01 4.41e-01 0.05110 0.049000 -0.014600 3.67e-01 7.87e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 63 7.35e-01 8.56e-01 0.05110 -0.015500 -0.048700 8.32e-01 5.04e-01
TELOMERE EXTENSION BY TELOMERASE 22 7.32e-01 8.54e-01 0.05090 0.042200 -0.028500 7.32e-01 8.17e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 5.75e-01 7.41e-01 0.05080 -0.020000 0.046700 8.20e-01 5.96e-01
RNA POLYMERASE III TRANSCRIPTION 41 7.73e-01 8.84e-01 0.05070 -0.049900 -0.008670 5.80e-01 9.24e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 7.08e-01 8.40e-01 0.05040 0.050400 -0.000737 5.77e-01 9.93e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 8.03e-01 9.02e-01 0.04960 0.038800 -0.030900 7.88e-01 8.31e-01
OXIDATIVE STRESS INDUCED SENESCENCE 77 5.38e-01 7.16e-01 0.04830 -0.001990 0.048300 9.76e-01 4.64e-01
FANCONI ANEMIA PATHWAY 36 9.14e-01 9.67e-01 0.04760 -0.025100 -0.040400 7.94e-01 6.75e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 56 5.02e-01 6.84e-01 0.04750 -0.026500 0.039400 7.31e-01 6.10e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 8.72e-01 9.46e-01 0.04740 -0.037400 0.029000 8.30e-01 8.68e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 9.81e-01 9.91e-01 0.04690 -0.030900 -0.035300 8.66e-01 8.47e-01
ERYTHROPOIETIN ACTIVATES RAS 13 8.54e-01 9.35e-01 0.04670 -0.037600 0.027800 8.15e-01 8.62e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 9.11e-01 9.65e-01 0.04640 -0.028200 -0.036900 7.41e-01 6.65e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 8.46e-01 9.31e-01 0.04540 -0.009960 0.044300 9.40e-01 7.38e-01
SIGNALING BY CSF3 G CSF 29 9.23e-01 9.70e-01 0.04530 -0.040600 -0.020200 7.05e-01 8.51e-01
RAC2 GTPASE CYCLE 88 6.20e-01 7.77e-01 0.04470 0.044400 0.004940 4.71e-01 9.36e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 18 9.11e-01 9.65e-01 0.04460 -0.044200 -0.006040 7.46e-01 9.65e-01
ACYL CHAIN REMODELLING OF PE 17 9.65e-01 9.84e-01 0.04370 -0.037000 -0.023300 7.92e-01 8.68e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 9.49e-01 9.83e-01 0.04340 0.004130 0.043200 9.82e-01 8.13e-01
PI METABOLISM 79 8.27e-01 9.16e-01 0.04340 0.020200 0.038400 7.56e-01 5.55e-01
INSULIN PROCESSING 24 7.89e-01 8.93e-01 0.04320 -0.021100 0.037800 8.58e-01 7.49e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 6.19e-01 7.77e-01 0.04240 0.042400 0.001270 4.97e-01 9.84e-01
SIGNALING BY ACTIVIN 12 8.99e-01 9.61e-01 0.04180 -0.017400 0.038100 9.17e-01 8.19e-01
REGULATION OF TP53 ACTIVITY 154 4.64e-01 6.52e-01 0.04180 -0.003270 -0.041600 9.44e-01 3.73e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.19e-01 9.69e-01 0.04130 -0.040700 -0.006690 7.53e-01 9.59e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 9.53e-01 9.84e-01 0.04110 0.025000 0.032600 8.13e-01 7.57e-01
MAPK FAMILY SIGNALING CASCADES 289 5.23e-01 7.02e-01 0.04020 -0.036300 -0.017100 2.89e-01 6.18e-01
SURFACTANT METABOLISM 16 8.73e-01 9.46e-01 0.04000 -0.019900 0.034700 8.90e-01 8.10e-01
DNA DOUBLE STRAND BREAK RESPONSE 51 9.17e-01 9.69e-01 0.03980 0.021700 0.033400 7.88e-01 6.80e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 286 5.75e-01 7.41e-01 0.03970 -0.034900 -0.019000 3.11e-01 5.81e-01
NOD1 2 SIGNALING PATHWAY 35 8.05e-01 9.02e-01 0.03890 0.007090 -0.038300 9.42e-01 6.95e-01
RHOG GTPASE CYCLE 74 9.08e-01 9.64e-01 0.03880 0.027800 0.027100 6.79e-01 6.87e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 9.46e-01 9.82e-01 0.03870 0.003710 -0.038500 9.84e-01 8.33e-01
TRANSPORT OF SMALL MOLECULES 587 6.92e-02 1.81e-01 0.03770 -0.000451 0.037700 9.85e-01 1.20e-01
HIV ELONGATION ARREST AND RECOVERY 32 8.39e-01 9.26e-01 0.03750 -0.005040 0.037200 9.61e-01 7.16e-01
CELLULAR SENESCENCE 140 3.51e-01 5.38e-01 0.03730 -0.019900 0.031500 6.84e-01 5.20e-01
GLUCOSE METABOLISM 81 9.07e-01 9.64e-01 0.03710 -0.027800 -0.024600 6.66e-01 7.01e-01
CARNITINE METABOLISM 14 9.49e-01 9.83e-01 0.03700 -0.004000 -0.036800 9.79e-01 8.12e-01
GOLGI TO ER RETROGRADE TRANSPORT 119 6.70e-01 8.14e-01 0.03680 -0.005830 -0.036300 9.13e-01 4.94e-01
SIGNALING BY HIPPO 20 9.34e-01 9.73e-01 0.03640 0.036000 0.005350 7.80e-01 9.67e-01
RHOF GTPASE CYCLE 41 7.49e-01 8.66e-01 0.03600 -0.019800 0.030000 8.26e-01 7.39e-01
SIGNALING BY VEGF 104 8.51e-01 9.33e-01 0.03570 -0.031200 -0.017300 5.83e-01 7.61e-01
SIGNALING BY ERBB2 IN CANCER 25 9.73e-01 9.88e-01 0.03540 -0.025800 -0.024200 8.23e-01 8.34e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 9.56e-01 9.84e-01 0.03540 -0.025400 -0.024600 7.76e-01 7.83e-01
EPH EPHRIN SIGNALING 92 5.27e-01 7.06e-01 0.03520 -0.024000 0.025800 6.91e-01 6.69e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 5.89e-01 7.50e-01 0.03510 0.019500 -0.029200 7.65e-01 6.53e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 9.66e-01 9.84e-01 0.03470 0.030500 0.016500 8.00e-01 8.91e-01
EGFR DOWNREGULATION 28 9.22e-01 9.70e-01 0.03390 -0.033500 -0.005290 7.59e-01 9.61e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 9.60e-01 9.84e-01 0.03360 -0.031100 -0.012800 7.96e-01 9.15e-01
STRIATED MUSCLE CONTRACTION 28 9.67e-01 9.84e-01 0.03310 0.028000 0.017500 7.97e-01 8.72e-01
SIGNALING BY FGFR3 35 9.64e-01 9.84e-01 0.03280 0.019400 0.026400 8.42e-01 7.87e-01
NUCLEAR IMPORT OF REV PROTEIN 32 9.65e-01 9.84e-01 0.03280 -0.018200 -0.027300 8.59e-01 7.89e-01
NUCLEOTIDE SALVAGE 21 8.93e-01 9.57e-01 0.03270 -0.013500 0.029800 9.14e-01 8.13e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 9.01e-01 9.62e-01 0.03270 -0.001620 0.032700 9.88e-01 7.65e-01
SUMOYLATION 162 6.31e-01 7.81e-01 0.03270 -0.032400 -0.003910 4.77e-01 9.32e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 368 1.38e-01 2.85e-01 0.03140 -0.024900 0.019100 4.12e-01 5.30e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 81 7.88e-01 8.93e-01 0.02980 -0.029800 0.000416 6.43e-01 9.95e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 9.52e-01 9.84e-01 0.02980 -0.009610 -0.028200 9.26e-01 7.86e-01
METABOLISM OF VITAMINS AND COFACTORS 153 4.90e-01 6.74e-01 0.02890 -0.021400 0.019400 6.48e-01 6.79e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.61e-01 9.84e-01 0.02850 0.028000 0.005530 8.24e-01 9.65e-01
CELL JUNCTION ORGANIZATION 74 7.18e-01 8.50e-01 0.02820 -0.020000 0.019900 7.66e-01 7.67e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 8.56e-01 9.35e-01 0.02810 -0.026900 -0.008290 6.37e-01 8.85e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 9.58e-01 9.84e-01 0.02710 -0.010100 -0.025100 9.15e-01 7.92e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 9.27e-01 9.72e-01 0.02670 -0.000704 -0.026700 9.94e-01 7.88e-01
SIGNALING BY FGFR4 33 8.93e-01 9.57e-01 0.02660 -0.009380 0.024900 9.26e-01 8.04e-01
FRS MEDIATED FGFR3 SIGNALING 15 9.89e-01 9.94e-01 0.02660 0.021900 0.015100 8.83e-01 9.20e-01
SHC MEDIATED CASCADE FGFR3 13 9.74e-01 9.88e-01 0.02450 -0.024500 0.000411 8.79e-01 9.98e-01
FRS MEDIATED FGFR4 SIGNALING 14 9.58e-01 9.84e-01 0.02380 -0.012800 0.020100 9.34e-01 8.96e-01
HEDGEHOG OFF STATE 107 9.17e-01 9.69e-01 0.02290 -0.008920 -0.021100 8.73e-01 7.06e-01
SYNTHESIS OF PC 27 9.66e-01 9.84e-01 0.02250 0.003410 0.022200 9.76e-01 8.41e-01
INTEGRIN CELL SURFACE INTERACTIONS 74 8.85e-01 9.51e-01 0.02180 0.001120 -0.021800 9.87e-01 7.46e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 9.86e-01 9.92e-01 0.02170 -0.014300 -0.016400 8.87e-01 8.71e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 9.78e-01 9.90e-01 0.02170 0.013500 0.017000 8.66e-01 8.32e-01
RECYCLING PATHWAY OF L1 40 9.84e-01 9.92e-01 0.02120 -0.014100 -0.015800 8.77e-01 8.63e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 9.75e-01 9.88e-01 0.02080 -0.001330 -0.020700 9.92e-01 8.73e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 9.72e-01 9.88e-01 0.02050 -0.002930 -0.020300 9.79e-01 8.58e-01
REGULATION OF PTEN GENE TRANSCRIPTION 59 9.30e-01 9.72e-01 0.02010 -0.020100 -0.000846 7.89e-01 9.91e-01
SIGNALING BY PTK6 50 9.21e-01 9.70e-01 0.01940 -0.004750 0.018800 9.54e-01 8.18e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 467 4.21e-01 6.12e-01 0.01940 -0.017600 0.008070 5.15e-01 7.66e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 44 9.73e-01 9.88e-01 0.01880 0.017800 0.006050 8.38e-01 9.45e-01
PI3K AKT SIGNALING IN CANCER 90 9.02e-01 9.62e-01 0.01810 0.000992 -0.018100 9.87e-01 7.67e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 9.50e-01 9.83e-01 0.01750 -0.016800 0.004900 8.60e-01 9.59e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 9.92e-01 9.95e-01 0.01700 -0.008610 -0.014600 9.42e-01 9.01e-01
NUCLEOBASE CATABOLISM 31 9.62e-01 9.84e-01 0.01660 -0.015900 0.004590 8.78e-01 9.65e-01
GENE SILENCING BY RNA 81 9.23e-01 9.70e-01 0.01560 -0.002670 0.015400 9.67e-01 8.11e-01
HCMV EARLY EVENTS 79 9.50e-01 9.83e-01 0.01550 0.001860 0.015400 9.77e-01 8.13e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 9.92e-01 9.95e-01 0.01450 -0.002140 -0.014300 9.89e-01 9.23e-01
SIGNALING BY WNT IN CANCER 31 9.86e-01 9.92e-01 0.01430 0.014000 0.003060 8.93e-01 9.76e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 9.35e-01 9.73e-01 0.01420 -0.010400 0.009680 8.90e-01 8.98e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.80e-01 9.91e-01 0.01410 -0.013100 0.005210 9.17e-01 9.67e-01
INTRA GOLGI TRAFFIC 43 9.82e-01 9.91e-01 0.01370 0.002740 0.013400 9.75e-01 8.79e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 9.82e-01 9.91e-01 0.01280 0.000683 -0.012800 9.95e-01 9.00e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 9.63e-01 9.84e-01 0.01270 -0.005950 -0.011200 8.89e-01 7.93e-01
GLYCOLYSIS 67 9.83e-01 9.91e-01 0.01130 -0.002900 -0.010900 9.67e-01 8.78e-01
LDL CLEARANCE 16 9.97e-01 9.97e-01 0.01040 0.003310 0.009820 9.82e-01 9.46e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.94e-01 9.96e-01 0.00971 0.009540 -0.001800 9.49e-01 9.90e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 9.91e-01 9.95e-01 0.00836 0.001940 0.008130 9.79e-01 9.14e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.97e-01 9.97e-01 0.00727 0.006970 0.002070 9.44e-01 9.83e-01


Detailed Gene set reports


ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN

ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
metric value
setSize 10
pMANOVA 0.000693
p.adjustMANOVA 0.00561
s.dist 0.892
s.LPS -0.692
s.OVA -0.563
p.LPS 0.000151
p.OVA 0.00205




Top 20 genes
Gene LPS OVA
Hbb-bt -7983 -6857
Cyb5r4 -7554 -6591
Cyb5r1 -5406 -7196
Cyb5r2 -6099 -5988
Hba-a1 -6310 -5779
Car2 -4699 -6537
Hba-a2 -5245 -4769
Aqp1 -8362 -2533
Car4 -6780 -2773

Click HERE to show all gene set members

All member genes
LPS OVA
Aqp1 -8362 -2533
Car2 -4699 -6537
Car4 -6780 -2773
Cyb5r1 -5406 -7196
Cyb5r2 -6099 -5988
Cyb5r4 -7554 -6591
Cyb5rl 1416 5646
Hba-a1 -6310 -5779
Hba-a2 -5245 -4769
Hbb-bt -7983 -6857



ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY
metric value
setSize 10
pMANOVA 0.000889
p.adjustMANOVA 0.00661
s.dist 0.839
s.LPS 0.684
s.OVA 0.486
p.LPS 0.000179
p.OVA 0.00777




Top 20 genes
Gene LPS OVA
Adcy6 8621 8729
Adcy4 8609 7834
Adcy5 7309 7928
Adcy2 5996 7601
Adcy8 7062 3791
Adcy3 5422 4730
Adcy7 5307 4413
Adcy9 5434 3895

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All member genes
LPS OVA
Adcy1 3240 -372
Adcy2 5996 7601
Adcy3 5422 4730
Adcy4 8609 7834
Adcy5 7309 7928
Adcy6 8621 8729
Adcy7 5307 4413
Adcy8 7062 3791
Adcy9 5434 3895
Gnal 4534 -1529



REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
metric value
setSize 17
pMANOVA 3.42e-05
p.adjustMANOVA 0.000543
s.dist 0.833
s.LPS 0.564
s.OVA 0.612
p.LPS 5.62e-05
p.OVA 1.23e-05




Top 20 genes
Gene LPS OVA
Ago2 8143 8690
Tnrc6b 8541 7734
Ptpn11 7236 9122
Ago3 8553 7711
Mov10 7233 8631
Ago1 6730 7354
Pml 6706 7315
Src 5353 7945
Runx1 5472 7062
Tnrc6a 7942 4593
Cdk6 6500 5231
Tnrc6c 5067 4920
Ccnd2 3324 6840
Ago4 5678 3081
Ccnd3 2192 4962

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All member genes
LPS OVA
Ago1 6730 7354
Ago2 8143 8690
Ago3 8553 7711
Ago4 5678 3081
Cbfb -2811 -1387
Ccnd1 -4838 -1404
Ccnd2 3324 6840
Ccnd3 2192 4962
Cdk6 6500 5231
Mov10 7233 8631
Pml 6706 7315
Ptpn11 7236 9122
Runx1 5472 7062
Src 5353 7945
Tnrc6a 7942 4593
Tnrc6b 8541 7734
Tnrc6c 5067 4920



TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
metric value
setSize 11
pMANOVA 0.00806
p.adjustMANOVA 0.0366
s.dist 0.711
s.LPS -0.515
s.OVA -0.49
p.LPS 0.0031
p.OVA 0.0049




Top 20 genes
Gene LPS OVA
Tlr3 -7448 -8079
Hsp90b1 -6938 -6184
Lgmn -6680 -6287
Ctss -5870 -4487
Ctsk -2416 -6463
Tlr7 -3873 -3980
Ctsl -6194 -2091
Ctsb -5407 -2202
Unc93b1 -977 -1333

Click HERE to show all gene set members

All member genes
LPS OVA
Cnpy3 -3393 3077
Ctsb -5407 -2202
Ctsk -2416 -6463
Ctsl -6194 -2091
Ctss -5870 -4487
Hsp90b1 -6938 -6184
Lgmn -6680 -6287
Tlr3 -7448 -8079
Tlr7 -3873 -3980
Tlr9 3230 -2761
Unc93b1 -977 -1333



YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
metric value
setSize 11
pMANOVA 0.0136
p.adjustMANOVA 0.0544
s.dist 0.669
s.LPS 0.452
s.OVA 0.493
p.LPS 0.00941
p.OVA 0.00462




Top 20 genes
Gene LPS OVA
Hipk2 8640 8909
Tead2 8312 8338
Hipk1 7534 8996
Tead3 8063 7857
Tead1 7083 7281
Yap1 6510 6846
Runx2 6452 6570
Tead4 1769 5775
Ccn2 1394 3356

Click HERE to show all gene set members

All member genes
LPS OVA
Ccn2 1394 3356
Hipk1 7534 8996
Hipk2 8640 8909
Kat2b -7861 -4863
Runx2 6452 6570
Tead1 7083 7281
Tead2 8312 8338
Tead3 8063 7857
Tead4 1769 5775
Wwtr1 -2193 -6680
Yap1 6510 6846



SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
metric value
setSize 29
pMANOVA 2.63e-05
p.adjustMANOVA 0.000461
s.dist 0.643
s.LPS -0.48
s.OVA -0.428
p.LPS 7.69e-06
p.OVA 6.59e-05




Top 20 genes
Gene LPS OVA
Ube2w -8315 -8028
Ube2g1 -8258 -7970
Ube2b -7902 -8069
Uchl3 -7998 -7873
Ube2a -7881 -7972
Ube2d1 -8181 -7637
Ube2l3 -7791 -7724
Ube2e1 -7933 -7579
Ube2e3 -8312 -7181
Ube2d2a -7661 -7345
Ube2k -7765 -7054
Ube2q2 -8138 -6060
Cdc34 -4437 -4995
Uba6 -3363 -6450
Ube2t -3494 -6145
Ube2s -4614 -3396
Ube2r2 -5497 -2037
Ubb -4186 -2003
Rps27a -4089 -1699
Usp9x -2397 -2821

Click HERE to show all gene set members

All member genes
LPS OVA
Cdc34 -4437 -4995
Otulin -4488 776
Rps27a -4089 -1699
Uba1 4425 2511
Uba52 3633 5393
Uba6 -3363 -6450
Ubb -4186 -2003
Ubc 3428 795
Ube2a -7881 -7972
Ube2b -7902 -8069
Ube2d1 -8181 -7637
Ube2d2a -7661 -7345
Ube2e1 -7933 -7579
Ube2e3 -8312 -7181
Ube2g1 -8258 -7970
Ube2g2 2712 5995
Ube2h 2237 7256
Ube2k -7765 -7054
Ube2l3 -7791 -7724
Ube2q2 -8138 -6060
Ube2r2 -5497 -2037
Ube2s -4614 -3396
Ube2t -3494 -6145
Ube2w -8315 -8028
Ube2z -1169 3093
Uchl3 -7998 -7873
Usp5 2209 3514
Usp7 2943 -1282
Usp9x -2397 -2821



INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS
metric value
setSize 27
pMANOVA 2.15e-05
p.adjustMANOVA 0.000388
s.dist 0.632
s.LPS 0.515
s.OVA 0.366
p.LPS 3.59e-06
p.OVA 0.000986




Top 20 genes
Gene LPS OVA
Sptbn4 8842 8034
Sptbn5 8318 7874
Nfasc 8774 7142
Kcnq2 8355 6975
Ank2 8276 7014
Scn5a 6331 8243
Sptbn1 6529 7593
Scn2b 6070 7858
Sptbn2 6654 6179
Sptan1 6674 4893
L1cam 6433 4996
Sptb 6808 4350
Scn3a 3351 7265
Scn7a 3921 4909
Scn3b 2204 7440
Scn9a 5323 2497
Ank3 7544 1741
Kcnq3 2085 6286
Scn2a 2447 4429
Scn8a 8067 871

Click HERE to show all gene set members

All member genes
LPS OVA
Actb -2601 1802
Actg1 -6150 -4790
Ank1 6581 290
Ank2 8276 7014
Ank3 7544 1741
Kcnq2 8355 6975
Kcnq3 2085 6286
L1cam 6433 4996
Nfasc 8774 7142
Nrcam 3422 498
Scn1a 1571 -5294
Scn1b -2514 -5584
Scn2a 2447 4429
Scn2b 6070 7858
Scn3a 3351 7265
Scn3b 2204 7440
Scn4b 3407 -4527
Scn5a 6331 8243
Scn7a 3921 4909
Scn8a 8067 871
Scn9a 5323 2497
Sptan1 6674 4893
Sptb 6808 4350
Sptbn1 6529 7593
Sptbn2 6654 6179
Sptbn4 8842 8034
Sptbn5 8318 7874



DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
metric value
setSize 20
pMANOVA 0.00135
p.adjustMANOVA 0.00932
s.dist 0.617
s.LPS 0.426
s.OVA 0.447
p.LPS 0.000978
p.OVA 0.000537




Top 20 genes
Gene LPS OVA
Cspg4 8265 8619
Ncan 7974 8751
Sdc4 7787 8957
Gpc4 6738 7797
Gpc3 5274 9070
Hspg2 4337 7459
Sdc3 4361 5946
B4galt7 2971 7391
Agrn 7613 2406
Vcan 3986 4189
Gpc2 7889 1773
Gpc1 4296 3208
Bgn 3992 1784
Dcn 235 5090

Click HERE to show all gene set members

All member genes
LPS OVA
Agrn 7613 2406
B4galt7 2971 7391
Bcan 7180 -606
Bgn 3992 1784
Cspg4 8265 8619
Cspg5 -573 4119
Dcn 235 5090
Gpc1 4296 3208
Gpc2 7889 1773
Gpc3 5274 9070
Gpc4 6738 7797
Gpc5 -311 5850
Gpc6 1253 -2604
Hspg2 4337 7459
Ncan 7974 8751
Sdc1 -59 -1194
Sdc2 -4687 -738
Sdc3 4361 5946
Sdc4 7787 8957
Vcan 3986 4189



P75NTR REGULATES AXONOGENESIS

P75NTR REGULATES AXONOGENESIS
metric value
setSize 10
pMANOVA 0.0397
p.adjustMANOVA 0.125
s.dist 0.61
s.LPS -0.439
s.OVA -0.424
p.LPS 0.0162
p.OVA 0.0202




Top 20 genes
Gene LPS OVA
Mcf2 -7420 -8092
Omg -7588 -7570
Rtn4 -6541 -5940
Rhoa -7488 -5019
Rtn4r -6421 -4812
Ngf -5404 -5686
Mag -1744 -3638

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All member genes
LPS OVA
Arhgdia 2827 8306
Lingo1 -238 241
Mag -1744 -3638
Mcf2 -7420 -8092
Ngf -5404 -5686
Ngfr 4789 778
Omg -7588 -7570
Rhoa -7488 -5019
Rtn4 -6541 -5940
Rtn4r -6421 -4812



A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
metric value
setSize 26
pMANOVA 0.000281
p.adjustMANOVA 0.00285
s.dist 0.592
s.LPS 0.381
s.OVA 0.452
p.LPS 0.000768
p.OVA 6.51e-05




Top 20 genes
Gene LPS OVA
Cspg4 8265 8619
Ncan 7974 8751
Sdc4 7787 8957
Xylt2 6799 8076
Gpc4 6738 7797
Gpc3 5274 9070
Hspg2 4337 7459
B3gat1 5118 5289
Sdc3 4361 5946
B4galt7 2971 7391
Agrn 7613 2406
Vcan 3986 4189
Gpc2 7889 1773
Gpc1 4296 3208
Xylt1 2326 3947
Bgn 3992 1784
B3gat2 268 6096
Dcn 235 5090
B3galt6 285 3865

Click HERE to show all gene set members

All member genes
LPS OVA
Agrn 7613 2406
B3galt6 285 3865
B3gat1 5118 5289
B3gat2 268 6096
B3gat3 -1268 63
B4galt7 2971 7391
Bcan 7180 -606
Bgn 3992 1784
Cspg4 8265 8619
Cspg5 -573 4119
Dcn 235 5090
Gpc1 4296 3208
Gpc2 7889 1773
Gpc3 5274 9070
Gpc4 6738 7797
Gpc5 -311 5850
Gpc6 1253 -2604
Hspg2 4337 7459
Ncan 7974 8751
Sdc1 -59 -1194
Sdc2 -4687 -738
Sdc3 4361 5946
Sdc4 7787 8957
Vcan 3986 4189
Xylt1 2326 3947
Xylt2 6799 8076



MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION
metric value
setSize 93
pMANOVA 9.54e-13
p.adjustMANOVA 2.24e-10
s.dist 0.586
s.LPS -0.4
s.OVA -0.428
p.LPS 2.52e-11
p.OVA 9.76e-13




Top 20 genes
Gene LPS OVA
Mrpl1 -8332 -7394
Mrps30 -8012 -7354
Mrpl16 -8130 -7209
Mrpl50 -8272 -7010
Mrpl3 -7472 -7390
Mrps31 -7947 -6778
Mrps22 -7509 -7173
Mrpl47 -7009 -7668
Mrpl32 -7187 -7449
Mrps2 -6728 -7630
Mrpl40 -7741 -6602
Mrpl10 -7816 -5897
Mrpl22 -6849 -6659
Ptcd3 -5492 -7906
Mrps23 -7129 -5644
Mrpl42 -5119 -7407
Mrps14 -6331 -5981
Mtif2 -4835 -7673
Mrpl15 -5853 -5887
Chchd1 -5250 -6013

Click HERE to show all gene set members

All member genes
LPS OVA
Aurkaip1 381 -326
Chchd1 -5250 -6013
Dap3 5439 5189
Eral1 3141 4293
Gadd45gip1 -3583 -2262
Gfm1 3876 -4676
Gfm2 6874 -3115
Mrpl1 -8332 -7394
Mrpl10 -7816 -5897
Mrpl11 -4921 -5383
Mrpl12 -3185 -4638
Mrpl13 -5777 -5366
Mrpl14 -653 1661
Mrpl15 -5853 -5887
Mrpl16 -8130 -7209
Mrpl17 -6185 -2812
Mrpl18 -3667 -6950
Mrpl19 -3124 -1962
Mrpl2 -2553 1097
Mrpl20 -3174 -3413
Mrpl21 -2929 -4866
Mrpl22 -6849 -6659
Mrpl23 -2021 -195
Mrpl24 -1549 -679
Mrpl27 -5367 -3576
Mrpl28 -3284 -2369
Mrpl3 -7472 -7390
Mrpl30 -5438 -4639
Mrpl32 -7187 -7449
Mrpl33 -5015 -4159
Mrpl34 -5587 -5537
Mrpl35 -2832 -5768
Mrpl36 -1407 -4506
Mrpl37 399 -3369
Mrpl38 2944 4153
Mrpl39 -4965 -4548
Mrpl4 5852 -1319
Mrpl40 -7741 -6602
Mrpl41 -1971 -515
Mrpl42 -5119 -7407
Mrpl43 -3273 -3957
Mrpl44 -3794 -2094
Mrpl46 -4620 -4621
Mrpl47 -7009 -7668
Mrpl48 -5037 -4765
Mrpl49 -5378 -3480
Mrpl50 -8272 -7010
Mrpl51 -3013 -4646
Mrpl52 -2852 -964
Mrpl53 -1913 -1753
Mrpl54 -3524 -2885
Mrpl55 -1632 -1840
Mrpl57 -5268 -1550
Mrpl58 -1603 -783
Mrpl9 -4916 -1670
Mrps10 -3511 -3240
Mrps11 -100 -1375
Mrps12 -2662 -3737
Mrps14 -6331 -5981
Mrps15 -2918 -421
Mrps16 -3079 -816
Mrps17 -4490 -541
Mrps18a -3195 -4351
Mrps18b -3825 -3628
Mrps18c -5075 -4274
Mrps2 -6728 -7630
Mrps21 -790 -2961
Mrps22 -7509 -7173
Mrps23 -7129 -5644
Mrps24 -2198 -1694
Mrps25 -3005 -1205
Mrps26 -3513 973
Mrps27 -3923 -4306
Mrps28 -3408 -146
Mrps30 -8012 -7354
Mrps31 -7947 -6778
Mrps33 -4098 -4435
Mrps34 380 1904
Mrps35 1561 -4367
Mrps36 -4558 -5016
Mrps5 -159 1304
Mrps6 680 968
Mrps7 -2486 -2229
Mrps9 -2460 -2975
Mrrf -4386 -6717
Mtfmt 5002 647
Mtif2 -4835 -7673
Mtif3 -3779 -259
Mtrf1l 5570 6374
Oxa1l -4478 -2530
Ptcd3 -5492 -7906
Tsfm -4273 -827
Tufm 4137 585



LGI ADAM INTERACTIONS

LGI ADAM INTERACTIONS
metric value
setSize 14
pMANOVA 0.0105
p.adjustMANOVA 0.0446
s.dist 0.583
s.LPS 0.466
s.OVA 0.35
p.LPS 0.00254
p.OVA 0.0232




Top 20 genes
Gene LPS OVA
Cacng8 7712 8208
Stx1a 6669 9047
Cacng4 6358 9030
Dlg4 6134 8965
Stx1b 7545 6444
Cacng3 5143 7314
Adam22 7853 4027
Lgi2 7064 2145
Cacng2 3124 3224
Adam11 7419 442

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All member genes
LPS OVA
Adam11 7419 442
Adam22 7853 4027
Adam23 1625 -4303
Cacng2 3124 3224
Cacng3 5143 7314
Cacng4 6358 9030
Cacng8 7712 8208
Dlg4 6134 8965
Lgi1 -6303 -6476
Lgi2 7064 2145
Lgi3 4193 -2980
Lgi4 -4719 4352
Stx1a 6669 9047
Stx1b 7545 6444



NOTCH HLH TRANSCRIPTION PATHWAY

NOTCH HLH TRANSCRIPTION PATHWAY
metric value
setSize 28
pMANOVA 0.00023
p.adjustMANOVA 0.00248
s.dist 0.572
s.LPS 0.361
s.OVA 0.444
p.LPS 0.000948
p.OVA 4.78e-05




Top 20 genes
Gene LPS OVA
Hdac5 8806 8987
Notch1 8721 8905
Ncor2 8756 8738
Notch3 8799 8649
Notch4 8781 8586
Hdac6 8728 7719
Crebbp 8422 7859
Ncor1 7485 8676
Hdac8 7520 8534
Notch2 6569 8550
Hdac4 6826 8193
Hdac11 4232 7903
Mamld1 4133 7043
Maml3 4126 5195
Hdac10 4258 4627
Maml2 1672 6065
Hdac7 6267 1598
Maml1 1125 4712
Tbl1x 326 2467

Click HERE to show all gene set members

All member genes
LPS OVA
Crebbp 8422 7859
Hdac1 -3681 1716
Hdac10 4258 4627
Hdac11 4232 7903
Hdac2 -7007 -6869
Hdac3 2499 -6262
Hdac4 6826 8193
Hdac5 8806 8987
Hdac6 8728 7719
Hdac7 6267 1598
Hdac8 7520 8534
Hdac9 -715 587
Kat2a 6280 -241
Kat2b -7861 -4863
Maml1 1125 4712
Maml2 1672 6065
Maml3 4126 5195
Mamld1 4133 7043
Ncor1 7485 8676
Ncor2 8756 8738
Notch1 8721 8905
Notch2 6569 8550
Notch3 8799 8649
Notch4 8781 8586
Rbpj -3061 2942
Snw1 -3468 1223
Tbl1x 326 2467
Tbl1xr1 -4299 124



CRISTAE FORMATION

CRISTAE FORMATION
metric value
setSize 31
pMANOVA 0.000175
p.adjustMANOVA 0.002
s.dist 0.568
s.LPS -0.397
s.OVA -0.406
p.LPS 0.00013
p.OVA 8.97e-05




Top 20 genes
Gene LPS OVA
Apoo -8099 -8090
Atp5c1 -8036 -7922
Mtx2 -7994 -7766
Atp5pb -7460 -7712
Dmac2l -7239 -7929
Apool -5489 -6607
Atp5o -4661 -6181
Atp5l -4647 -6085
Atp5h -4775 -5491
Atp5b -4848 -5408
Chchd3 -4600 -5336
mt-Atp6 -5033 -4674
Immt -3500 -5183
Atp5g3 -4423 -3683
Atp5a1 -4467 -3463
Micos10 -3115 -4037
Hspa9 -3309 -2548
Micos13 -2545 -2850
Tmem11 -3438 -2105
Atp5j2 -1497 -2315

Click HERE to show all gene set members

All member genes
LPS OVA
Apoo -8099 -8090
Apool -5489 -6607
Atp5a1 -4467 -3463
Atp5b -4848 -5408
Atp5c1 -8036 -7922
Atp5d 317 -1641
Atp5e -1106 1068
Atp5g1 1337 396
Atp5g2 -3028 798
Atp5g3 -4423 -3683
Atp5h -4775 -5491
Atp5j -1090 -1383
Atp5j2 -1497 -2315
Atp5k 2026 2297
Atp5l -4647 -6085
Atp5o -4661 -6181
Atp5pb -7460 -7712
Chchd3 -4600 -5336
Chchd6 -3265 -299
Dmac2l -7239 -7929
Dnajc11 3650 2911
Hspa9 -3309 -2548
Immt -3500 -5183
Micos10 -3115 -4037
Micos13 -2545 -2850
mt-Atp6 -5033 -4674
mt-Atp8 7204 8275
Mtx1 -5695 279
Mtx2 -7994 -7766
Samm50 893 145
Tmem11 -3438 -2105



SIGNALING BY LEPTIN

SIGNALING BY LEPTIN
metric value
setSize 10
pMANOVA 0.0615
p.adjustMANOVA 0.169
s.dist 0.568
s.LPS 0.401
s.OVA 0.402
p.LPS 0.028
p.OVA 0.0278




Top 20 genes
Gene LPS OVA
Sh2b1 8659 8117
Stat3 7736 8754
Ptpn11 7236 9122
Stat5b 5493 8177
Irs2 3197 2925
Irs1 3394 1941
Socs3 2035 1326

Click HERE to show all gene set members

All member genes
LPS OVA
Irs1 3394 1941
Irs2 3197 2925
Jak2 -2161 416
Lepr -2517 33
Ptpn11 7236 9122
Sh2b1 8659 8117
Socs3 2035 1326
Stat3 7736 8754
Stat5a 4103 -1051
Stat5b 5493 8177



FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
metric value
setSize 19
pMANOVA 0.00597
p.adjustMANOVA 0.0293
s.dist 0.558
s.LPS -0.392
s.OVA -0.398
p.LPS 0.00313
p.OVA 0.00266




Top 20 genes
Gene LPS OVA
Cct6a -7913 -6764
Tcp1 -7344 -6682
Cct4 -7393 -6474
Tuba1c -7887 -4801
Cct2 -6927 -5361
Tuba8 -4951 -7088
Cct7 -5812 -5404
Tuba4a -3766 -6669
Cct8 -5431 -4458
Tuba1b -4403 -5451
Cct5 -5831 -3366
Tubb4b -2611 -6315
Cct3 -2847 -1055

Click HERE to show all gene set members

All member genes
LPS OVA
Cct2 -6927 -5361
Cct3 -2847 -1055
Cct4 -7393 -6474
Cct5 -5831 -3366
Cct6a -7913 -6764
Cct7 -5812 -5404
Cct8 -5431 -4458
Tcp1 -7344 -6682
Tuba1a -1704 672
Tuba1b -4403 -5451
Tuba1c -7887 -4801
Tuba4a -3766 -6669
Tuba8 -4951 -7088
Tubb2a 873 5471
Tubb2b 4225 6170
Tubb3 478 -3804
Tubb4a 4648 971
Tubb4b -2611 -6315
Tubb6 5449 5009



CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT

CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT
metric value
setSize 20
pMANOVA 0.00272
p.adjustMANOVA 0.0165
s.dist 0.554
s.LPS -0.444
s.OVA -0.332
p.LPS 0.000589
p.OVA 0.0102




Top 20 genes
Gene LPS OVA
Pex3 -8008 -7909
Atad1 -8302 -7540
Acbd5 -7579 -8017
Abcd2 -7474 -8106
Pex13 -7477 -7061
Gdap1 -6664 -7062
Slc25a17 -7760 -5755
Pex2 -7281 -5273
Pex11b -6323 -3421
Aldh3a2 -3281 -3906
Abcd3 -3402 -3044
Pex19 -2624 -1036
Fis1 -2104 -420

Click HERE to show all gene set members

All member genes
LPS OVA
Abcd1 7792 5023
Abcd2 -7474 -8106
Abcd3 -3402 -3044
Acbd5 -7579 -8017
Aldh3a2 -3281 -3906
Atad1 -8302 -7540
Fis1 -2104 -420
Gdap1 -6664 -7062
Pex11b -6323 -3421
Pex12 169 -2808
Pex13 -7477 -7061
Pex14 -2335 3346
Pex16 954 3531
Pex19 -2624 -1036
Pex2 -7281 -5273
Pex26 2501 5758
Pex3 -8008 -7909
Pxmp2 -993 5067
Pxmp4 -1078 1760
Slc25a17 -7760 -5755



RUNX3 REGULATES NOTCH SIGNALING

RUNX3 REGULATES NOTCH SIGNALING
metric value
setSize 13
pMANOVA 0.0184
p.adjustMANOVA 0.0704
s.dist 0.552
s.LPS 0.316
s.OVA 0.452
p.LPS 0.0485
p.OVA 0.00475




Top 20 genes
Gene LPS OVA
Jag1 8698 8953
Notch1 8721 8905
Crebbp 8422 7859
Hes1 5501 5618
Mamld1 4133 7043
Maml3 4126 5195
Ep300 4472 3909
Maml2 1672 6065
Maml1 1125 4712

Click HERE to show all gene set members

All member genes
LPS OVA
Crebbp 8422 7859
Ep300 4472 3909
Hes1 5501 5618
Jag1 8698 8953
Kat2a 6280 -241
Kat2b -7861 -4863
Maml1 1125 4712
Maml2 1672 6065
Maml3 4126 5195
Mamld1 4133 7043
Notch1 8721 8905
Rbpj -3061 2942
Snw1 -3468 1223



NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
metric value
setSize 20
pMANOVA 0.000686
p.adjustMANOVA 0.0056
s.dist 0.544
s.LPS 0.262
s.OVA 0.476
p.LPS 0.0422
p.OVA 0.000229




Top 20 genes
Gene LPS OVA
Notch1 8721 8905
Notch4 8781 8586
Crebbp 8422 7859
Notch2 6569 8550
Hes1 5501 5618
Mamld1 4133 7043
Maml3 4126 5195
Hes5 2065 8635
Ep300 4472 3909
Smad3 3231 5305
Flt4 1965 6113
Maml2 1672 6065
Maml1 1125 4712

Click HERE to show all gene set members

All member genes
LPS OVA
Acta2 2961 -2717
Crebbp 8422 7859
Ep300 4472 3909
Flt4 1965 6113
Hes1 5501 5618
Hes5 2065 8635
Hey1 -4130 2959
Hey2 -1116 6439
Kat2a 6280 -241
Kat2b -7861 -4863
Maml1 1125 4712
Maml2 1672 6065
Maml3 4126 5195
Mamld1 4133 7043
Notch1 8721 8905
Notch2 6569 8550
Notch4 8781 8586
Rbpj -3061 2942
Smad3 3231 5305
Snw1 -3468 1223



NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
metric value
setSize 11
pMANOVA 0.00587
p.adjustMANOVA 0.029
s.dist 0.543
s.LPS 0.205
s.OVA 0.503
p.LPS 0.238
p.OVA 0.00386




Top 20 genes
Gene LPS OVA
Notch2 6569 8550
Hes1 5501 5618
Mamld1 4133 7043
Maml3 4126 5195
Hes5 2065 8635
Ep300 4472 3909
Maml2 1672 6065
Maml1 1125 4712

Click HERE to show all gene set members

All member genes
LPS OVA
Creb1 -4058 -2247
Ep300 4472 3909
Fcer2a -222 2900
Hes1 5501 5618
Hes5 2065 8635
Maml1 1125 4712
Maml2 1672 6065
Maml3 4126 5195
Mamld1 4133 7043
Notch2 6569 8550
Rbpj -3061 2942



PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
metric value
setSize 11
pMANOVA 0.0382
p.adjustMANOVA 0.122
s.dist 0.543
s.LPS 0.444
s.OVA 0.312
p.LPS 0.0107
p.OVA 0.0735




Top 20 genes
Gene LPS OVA
Cacna1b 8068 8049
Cacna1e 7398 8154
Cacng4 6358 9030
Cacnb3 6553 8648
Cacnb1 6043 6744
Cacna2d2 5706 3359
Cacna1a 6579 2429
Cacng2 3124 3224
Cacnb2 919 335

Click HERE to show all gene set members

All member genes
LPS OVA
Cacna1a 6579 2429
Cacna1b 8068 8049
Cacna1e 7398 8154
Cacna2d2 5706 3359
Cacna2d3 420 -7075
Cacnb1 6043 6744
Cacnb2 919 335
Cacnb3 6553 8648
Cacnb4 -6199 -7718
Cacng2 3124 3224
Cacng4 6358 9030



REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
metric value
setSize 10
pMANOVA 0.0569
p.adjustMANOVA 0.16
s.dist 0.542
s.LPS 0.319
s.OVA 0.437
p.LPS 0.0803
p.OVA 0.0166




Top 20 genes
Gene LPS OVA
Slit1 6679 7275
Src 5353 7945
Robo3 6899 4571
Slit2 4632 5344
Dcc 3072 7949
Ntn1 2696 7063
Robo1 4384 3818
Nell2 554 4151

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All member genes
LPS OVA
Dcc 3072 7949
Nell2 554 4151
Ntn1 2696 7063
Robo1 4384 3818
Robo2 -974 -1320
Robo3 6899 4571
Slit1 6679 7275
Slit2 4632 5344
Slit3 -3183 -3985
Src 5353 7945



COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
metric value
setSize 26
pMANOVA 0.00137
p.adjustMANOVA 0.00933
s.dist 0.541
s.LPS -0.393
s.OVA -0.371
p.LPS 0.000526
p.OVA 0.00104




Top 20 genes
Gene LPS OVA
Vbp1 -8222 -7941
Pfdn4 -7351 -7812
Cct6a -7913 -6764
Tcp1 -7344 -6682
Cct4 -7393 -6474
Tuba1c -7887 -4801
Cct2 -6927 -5361
Tuba8 -4951 -7088
Cct7 -5812 -5404
Tuba4a -3766 -6669
Cct8 -5431 -4458
Tuba1b -4403 -5451
Cct5 -5831 -3366
Tubb4b -2611 -6315
Pfdn1 -4284 -3769
Cct3 -2847 -1055
Pfdn6 -1510 -1691

Click HERE to show all gene set members

All member genes
LPS OVA
Actb -2601 1802
Cct2 -6927 -5361
Cct3 -2847 -1055
Cct4 -7393 -6474
Cct5 -5831 -3366
Cct6a -7913 -6764
Cct7 -5812 -5404
Cct8 -5431 -4458
Pfdn1 -4284 -3769
Pfdn2 3971 3496
Pfdn4 -7351 -7812
Pfdn5 -2044 1518
Pfdn6 -1510 -1691
Tcp1 -7344 -6682
Tuba1a -1704 672
Tuba1b -4403 -5451
Tuba1c -7887 -4801
Tuba4a -3766 -6669
Tuba8 -4951 -7088
Tubb2a 873 5471
Tubb2b 4225 6170
Tubb3 478 -3804
Tubb4a 4648 971
Tubb4b -2611 -6315
Tubb6 5449 5009
Vbp1 -8222 -7941



RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
metric value
setSize 102
pMANOVA 8.3e-12
p.adjustMANOVA 9.77e-10
s.dist 0.539
s.LPS -0.384
s.OVA -0.378
p.LPS 2.12e-11
p.OVA 3.99e-11




Top 20 genes
Gene LPS OVA
Ndufaf4 -7518 -7833
Ndufaf1 -7740 -7433
Ndufv2 -7248 -7620
Cycs -6806 -7995
Uqcrc2 -6971 -6908
Coq10b -7478 -6201
Ndufaf5 -6087 -7046
Etfa -6677 -6309
mt-Co2 -5501 -7646
Ndufc2 -6854 -5670
Uqcrfs1 -6258 -6206
Sdhb -6037 -6104
Ndufs4 -6153 -5964
mt-Nd6 -6506 -5625
Ndufb5 -5725 -6211
Etfdh -7098 -4870
Ndufaf2 -5918 -5834
mt-Nd2 -7018 -4746
Ndufs1 -5615 -5618
Sco1 -5118 -6137

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 -677 -2478
Coq10a -2669 -4035
Coq10b -7478 -6201
Cox11 -2192 -880
Cox14 -2673 -4176
Cox16 -3224 -7097
Cox18 -1085 1678
Cox19 1626 1226
Cox20 -1698 -992
Cox4i1 -2474 -2071
Cox5a -4253 -5811
Cox5b 1144 1275
Cox6a1 -2751 -2367
Cox6b1 -3826 -4348
Cox6c -1376 -973
Cox7a2l -4676 -2372
Cox7b -3286 -5541
Cox7c -2914 -2009
Cox8a -1251 2958
Cyc1 -4060 -4414
Cycs -6806 -7995
Ecsit -2853 -792
Etfa -6677 -6309
Etfb -4034 923
Etfdh -7098 -4870
Lrpprc 2463 -2246
mt-Co1 -5609 -2352
mt-Co2 -5501 -7646
mt-Co3 -5091 -5245
mt-Cytb -5464 -3495
mt-Nd1 -5959 -4808
mt-Nd2 -7018 -4746
mt-Nd3 254 4569
mt-Nd4 -6158 -3933
mt-Nd5 -5883 -1883
mt-Nd6 -6506 -5625
Ndufa1 -459 -969
Ndufa10 -4264 -6584
Ndufa11 -3098 -4609
Ndufa12 3430 814
Ndufa13 1607 3362
Ndufa2 -1508 192
Ndufa3 1785 2432
Ndufa4 -3802 -4264
Ndufa5 -1322 -2826
Ndufa6 -550 -725
Ndufa7 -2619 673
Ndufa8 -1957 -884
Ndufa9 -2826 -4055
Ndufab1 -4234 -5870
Ndufaf1 -7740 -7433
Ndufaf2 -5918 -5834
Ndufaf3 -1229 1625
Ndufaf4 -7518 -7833
Ndufaf5 -6087 -7046
Ndufaf6 356 -5557
Ndufaf7 1828 4134
Ndufb1 -1089 286
Ndufb10 -2923 -5202
Ndufb11 -4941 -4738
Ndufb2 -2450 -3680
Ndufb3 -4203 -3443
Ndufb4 -4219 -1828
Ndufb5 -5725 -6211
Ndufb6 -3321 -5436
Ndufb7 -637 522
Ndufb8 -3888 -3598
Ndufb9 -4205 -3191
Ndufc1 -2328 -3137
Ndufc2 -6854 -5670
Ndufs1 -5615 -5618
Ndufs2 -2560 -313
Ndufs3 -4323 -5088
Ndufs4 -6153 -5964
Ndufs5 -2817 -4378
Ndufs6 983 965
Ndufs7 1862 536
Ndufs8 -4515 -6310
Ndufv1 -1535 -1886
Ndufv2 -7248 -7620
Ndufv3 1170 524
Nubpl -7141 -4162
Sco1 -5118 -6137
Sco2 -8317 -39
Sdha -732 1601
Sdhb -6037 -6104
Sdhc -5010 -1445
Sdhd -5537 -2712
Surf1 -4280 -3080
Taco1 748 -2332
Timmdc1 -802 127
Tmem126b -3311 -2414
Tmem186 6858 6726
Trap1 4891 -870
Uqcr10 649 1013
Uqcr11 -113 1026
Uqcrb -3702 -3671
Uqcrc1 -1843 -2143
Uqcrc2 -6971 -6908
Uqcrfs1 -6258 -6206
Uqcrh -4394 -3922
Uqcrq -1273 -45



RORA ACTIVATES GENE EXPRESSION

RORA ACTIVATES GENE EXPRESSION
metric value
setSize 18
pMANOVA 0.00898
p.adjustMANOVA 0.0393
s.dist 0.534
s.LPS 0.416
s.OVA 0.336
p.LPS 0.00227
p.OVA 0.0137




Top 20 genes
Gene LPS OVA
Rxra 7923 8974
Srebf1 7830 8799
Crebbp 8422 7859
Helz2 6328 8330
Chd9 7334 6607
Carm1 6205 4892
Ppara 4271 6024
Ep300 4472 3909
Med1 6680 2439
Ncoa6 5813 2409
Ncoa1 4369 2625
Cpt1a 2843 3108
Ncoa2 2516 1840
Tbl1x 326 2467

Click HERE to show all gene set members

All member genes
LPS OVA
Carm1 6205 4892
Chd9 7334 6607
Cpt1a 2843 3108
Crebbp 8422 7859
Ep300 4472 3909
Helz2 6328 8330
Med1 6680 2439
Ncoa1 4369 2625
Ncoa2 2516 1840
Ncoa6 5813 2409
Ppara 4271 6024
Rora -2337 -7221
Rxra 7923 8974
Smarcd3 1686 -451
Srebf1 7830 8799
Tbl1x 326 2467
Tbl1xr1 -4299 124
Tgs1 -1297 -1454



FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
metric value
setSize 18
pMANOVA 0.012
p.adjustMANOVA 0.0497
s.dist 0.531
s.LPS -0.362
s.OVA -0.389
p.LPS 0.00788
p.OVA 0.00429




Top 20 genes
Gene LPS OVA
Atp5c1 -8036 -7922
Atp5pb -7460 -7712
Dmac2l -7239 -7929
Atp5o -4661 -6181
Atp5l -4647 -6085
Atp5h -4775 -5491
Atp5b -4848 -5408
mt-Atp6 -5033 -4674
Atp5g3 -4423 -3683
Atp5a1 -4467 -3463
Atp5j2 -1497 -2315
Atp5j -1090 -1383

Click HERE to show all gene set members

All member genes
LPS OVA
Atp5a1 -4467 -3463
Atp5b -4848 -5408
Atp5c1 -8036 -7922
Atp5d 317 -1641
Atp5e -1106 1068
Atp5g1 1337 396
Atp5g2 -3028 798
Atp5g3 -4423 -3683
Atp5h -4775 -5491
Atp5j -1090 -1383
Atp5j2 -1497 -2315
Atp5k 2026 2297
Atp5l -4647 -6085
Atp5o -4661 -6181
Atp5pb -7460 -7712
Dmac2l -7239 -7929
mt-Atp6 -5033 -4674
mt-Atp8 7204 8275



ENDOSOMAL VACUOLAR PATHWAY

ENDOSOMAL VACUOLAR PATHWAY
metric value
setSize 10
pMANOVA 0.000804
p.adjustMANOVA 0.0061
s.dist 0.529
s.LPS -0.523
s.OVA -0.0797
p.LPS 0.00417
p.OVA 0.662




Top 20 genes
Gene LPS OVA
B2m -7287 -4887
Ctss -5870 -4487
Ctsl -6194 -2091

Click HERE to show all gene set members

All member genes
LPS OVA
B2m -7287 -4887
Ctsl -6194 -2091
Ctss -5870 -4487
H2-D1 -5796 3215
H2-M3 -6856 899
H2-Q10 700 -6023
H2-Q2 -3120 4472
H2-Q7 -4522 1733
H2-T23 -7956 2463
Lnpep 4409 2965



INTERLEUKIN 6 SIGNALING

INTERLEUKIN 6 SIGNALING
metric value
setSize 10
pMANOVA 0.086
p.adjustMANOVA 0.208
s.dist 0.529
s.LPS 0.353
s.OVA 0.393
p.LPS 0.0532
p.OVA 0.0313




Top 20 genes
Gene LPS OVA
Stat3 7736 8754
Ptpn11 7236 9122
Cbl 7975 8256
Il6st 7675 8359
Tyk2 7451 5625
Il6ra 1228 6833
Socs3 2035 1326

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All member genes
LPS OVA
Cbl 7975 8256
Il6ra 1228 6833
Il6st 7675 8359
Jak1 -688 -4032
Jak2 -2161 416
Ptpn11 7236 9122
Socs3 2035 1326
Stat1 -5473 -5637
Stat3 7736 8754
Tyk2 7451 5625



PENTOSE PHOSPHATE PATHWAY

PENTOSE PHOSPHATE PATHWAY
metric value
setSize 13
pMANOVA 0.0425
p.adjustMANOVA 0.131
s.dist 0.525
s.LPS -0.393
s.OVA -0.349
p.LPS 0.0142
p.OVA 0.0294




Top 20 genes
Gene LPS OVA
Rpe -7836 -7629
Prps2 -8230 -6887
Rbks -7572 -7307
Pgm2 -6585 -5789
Taldo1 -6826 -4799
Shpk -2508 -5695
G6pdx -1608 -2557

Click HERE to show all gene set members

All member genes
LPS OVA
Dera 1596 -4686
G6pdx -1608 -2557
Pgd 1827 7349
Pgls -212 3994
Pgm2 -6585 -5789
Prps1 -4869 1278
Prps2 -8230 -6887
Rbks -7572 -7307
Rpe -7836 -7629
Rpia 3162 -677
Shpk -2508 -5695
Taldo1 -6826 -4799
Tkt -947 1005



E2F MEDIATED REGULATION OF DNA REPLICATION

E2F MEDIATED REGULATION OF DNA REPLICATION
metric value
setSize 20
pMANOVA 0.00888
p.adjustMANOVA 0.039
s.dist 0.521
s.LPS -0.357
s.OVA -0.38
p.LPS 0.00572
p.OVA 0.00325




Top 20 genes
Gene LPS OVA
Ppp2cb -8331 -8002
Orc5 -7766 -7983
Orc6 -7733 -7614
Orc4 -7332 -7976
Prim1 -7055 -7107
Ppp2ca -6912 -6549
Cdk1 -6950 -4504
Orc2 -5769 -3286
Rb1 -3721 -4986
Ppp2r1a -4966 -1564
Orc3 -1276 -4855
Pola2 -697 -4279

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk1 -6950 -4504
E2f1 3805 -285
Mcm8 -2225 1086
Orc2 -5769 -3286
Orc3 -1276 -4855
Orc4 -7332 -7976
Orc5 -7766 -7983
Orc6 -7733 -7614
Pola1 3966 -563
Pola2 -697 -4279
Ppp2ca -6912 -6549
Ppp2cb -8331 -8002
Ppp2r1a -4966 -1564
Ppp2r1b 651 3970
Ppp2r3d 3711 5304
Prim1 -7055 -7107
Prim2 -3346 3562
Rb1 -3721 -4986
Tfdp1 5577 3159
Tfdp2 67 -2741



CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
metric value
setSize 11
pMANOVA 0.0753
p.adjustMANOVA 0.191
s.dist 0.521
s.LPS -0.358
s.OVA -0.378
p.LPS 0.0398
p.OVA 0.03




Top 20 genes
Gene LPS OVA
Ywhaq -8288 -7456
Ywhab -7624 -5335
Cdk1 -6950 -4504
Ywhah -5184 -4938
Ywhae -7268 -3432
Ywhaz -6933 -2916
Wee1 -4171 -3569

Click HERE to show all gene set members

All member genes
LPS OVA
Cdk1 -6950 -4504
Chek1 1162 -6858
Chek2 1383 -1855
Sfn 8391 7209
Wee1 -4171 -3569
Ywhab -7624 -5335
Ywhae -7268 -3432
Ywhag 4402 3474
Ywhah -5184 -4938
Ywhaq -8288 -7456
Ywhaz -6933 -2916



ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY
metric value
setSize 13
pMANOVA 0.0473
p.adjustMANOVA 0.142
s.dist 0.519
s.LPS 0.382
s.OVA 0.351
p.LPS 0.0171
p.OVA 0.0285




Top 20 genes
Gene LPS OVA
Adcy6 8621 8729
Adcy4 8609 7834
Adcy5 7309 7928
Adcy2 5996 7601
Adcy8 7062 3791
Adcy3 5422 4730
Adcy7 5307 4413
Adcy9 5434 3895

Click HERE to show all gene set members

All member genes
LPS OVA
Adcy1 3240 -372
Adcy2 5996 7601
Adcy3 5422 4730
Adcy4 8609 7834
Adcy5 7309 7928
Adcy6 8621 8729
Adcy7 5307 4413
Adcy8 7062 3791
Adcy9 5434 3895
Gnai1 -6416 -5030
Gnai2 -2209 8448
Gnai3 -6773 -4484
Gnal 4534 -1529



NR1H2 AND NR1H3 MEDIATED SIGNALING

NR1H2 AND NR1H3 MEDIATED SIGNALING
metric value
setSize 38
pMANOVA 0.000104
p.adjustMANOVA 0.00126
s.dist 0.517
s.LPS 0.331
s.OVA 0.397
p.LPS 0.000423
p.OVA 2.24e-05




Top 20 genes
Gene LPS OVA
Ncor2 8756 8738
Rxra 7923 8974
Ago2 8143 8690
Srebf1 7830 8799
Tnrc6b 8541 7734
Ago3 8553 7711
Ncor1 7485 8676
Mov10 7233 8631
Kdm4a 7344 7972
Ago1 6730 7354
Fasn 6573 7170
Tnrc6a 7942 4593
Gps2 6076 5942
Tnrc6c 5067 4920
Scd2 3823 6041
Abca1 3299 5619
Ago4 5678 3081
Ep300 4472 3909
Nr1h3 4216 3703
Ncoa1 4369 2625

Click HERE to show all gene set members

All member genes
LPS OVA
Abca1 3299 5619
Abcg1 1531 5197
Ago1 6730 7354
Ago2 8143 8690
Ago3 8553 7711
Ago4 5678 3081
Apoc1 -6072 -829
Apod -6601 -3619
Apoe -96 6582
Arl4c -3091 -2377
Eepd1 750 3956
Ep300 4472 3909
Fasn 6573 7170
Gps2 6076 5942
Hdac3 2499 -6262
Kdm1a -1184 -806
Kdm1b -3822 490
Kdm3a 2416 3212
Kdm4a 7344 7972
Mov10 7233 8631
Mylip 1647 1675
Ncoa1 4369 2625
Ncor1 7485 8676
Ncor2 8756 8738
Nr1h2 4686 -29
Nr1h3 4216 3703
Nrip1 -3027 -5211
Pltp 1192 5675
Rxra 7923 8974
Rxrb -75 2473
Scd1 1053 5807
Scd2 3823 6041
Srebf1 7830 8799
Tbl1x 326 2467
Tbl1xr1 -4299 124
Tnrc6a 7942 4593
Tnrc6b 8541 7734
Tnrc6c 5067 4920



NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX

NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
metric value
setSize 32
pMANOVA 0.000471
p.adjustMANOVA 0.0041
s.dist 0.516
s.LPS 0.333
s.OVA 0.395
p.LPS 0.00111
p.OVA 0.000111




Top 20 genes
Gene LPS OVA
Ncor2 8756 8738
Rxra 7923 8974
Ago2 8143 8690
Tnrc6b 8541 7734
Ago3 8553 7711
Ncor1 7485 8676
Mov10 7233 8631
Kdm4a 7344 7972
Ago1 6730 7354
Tnrc6a 7942 4593
Gps2 6076 5942
Tnrc6c 5067 4920
Abca1 3299 5619
Ago4 5678 3081
Ep300 4472 3909
Nr1h3 4216 3703
Ncoa1 4369 2625
Abcg1 1531 5197
Kdm3a 2416 3212
Pltp 1192 5675

Click HERE to show all gene set members

All member genes
LPS OVA
Abca1 3299 5619
Abcg1 1531 5197
Ago1 6730 7354
Ago2 8143 8690
Ago3 8553 7711
Ago4 5678 3081
Apoc1 -6072 -829
Apod -6601 -3619
Apoe -96 6582
Arl4c -3091 -2377
Eepd1 750 3956
Ep300 4472 3909
Gps2 6076 5942
Hdac3 2499 -6262
Kdm1a -1184 -806
Kdm1b -3822 490
Kdm3a 2416 3212
Kdm4a 7344 7972
Mov10 7233 8631
Ncoa1 4369 2625
Ncor1 7485 8676
Ncor2 8756 8738
Nr1h2 4686 -29
Nr1h3 4216 3703
Pltp 1192 5675
Rxra 7923 8974
Rxrb -75 2473
Tbl1x 326 2467
Tbl1xr1 -4299 124
Tnrc6a 7942 4593
Tnrc6b 8541 7734
Tnrc6c 5067 4920



COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
metric value
setSize 56
pMANOVA 3e-06
p.adjustMANOVA 6.66e-05
s.dist 0.513
s.LPS -0.361
s.OVA -0.365
p.LPS 3.04e-06
p.OVA 2.32e-06




Top 20 genes
Gene LPS OVA
Ndufaf4 -7518 -7833
Ndufaf1 -7740 -7433
Ndufv2 -7248 -7620
Ndufaf5 -6087 -7046
Ndufc2 -6854 -5670
Ndufs4 -6153 -5964
mt-Nd6 -6506 -5625
Ndufb5 -5725 -6211
Ndufaf2 -5918 -5834
mt-Nd2 -7018 -4746
Ndufs1 -5615 -5618
Nubpl -7141 -4162
mt-Nd1 -5959 -4808
Ndufs8 -4515 -6310
Ndufa10 -4264 -6584
Ndufab1 -4234 -5870
mt-Nd4 -6158 -3933
Ndufb11 -4941 -4738
Ndufs3 -4323 -5088
Ndufb6 -3321 -5436

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 -677 -2478
Ecsit -2853 -792
mt-Nd1 -5959 -4808
mt-Nd2 -7018 -4746
mt-Nd3 254 4569
mt-Nd4 -6158 -3933
mt-Nd5 -5883 -1883
mt-Nd6 -6506 -5625
Ndufa1 -459 -969
Ndufa10 -4264 -6584
Ndufa11 -3098 -4609
Ndufa12 3430 814
Ndufa13 1607 3362
Ndufa2 -1508 192
Ndufa3 1785 2432
Ndufa5 -1322 -2826
Ndufa6 -550 -725
Ndufa7 -2619 673
Ndufa8 -1957 -884
Ndufa9 -2826 -4055
Ndufab1 -4234 -5870
Ndufaf1 -7740 -7433
Ndufaf2 -5918 -5834
Ndufaf3 -1229 1625
Ndufaf4 -7518 -7833
Ndufaf5 -6087 -7046
Ndufaf6 356 -5557
Ndufaf7 1828 4134
Ndufb1 -1089 286
Ndufb10 -2923 -5202
Ndufb11 -4941 -4738
Ndufb2 -2450 -3680
Ndufb3 -4203 -3443
Ndufb4 -4219 -1828
Ndufb5 -5725 -6211
Ndufb6 -3321 -5436
Ndufb7 -637 522
Ndufb8 -3888 -3598
Ndufb9 -4205 -3191
Ndufc1 -2328 -3137
Ndufc2 -6854 -5670
Ndufs1 -5615 -5618
Ndufs2 -2560 -313
Ndufs3 -4323 -5088
Ndufs4 -6153 -5964
Ndufs5 -2817 -4378
Ndufs6 983 965
Ndufs7 1862 536
Ndufs8 -4515 -6310
Ndufv1 -1535 -1886
Ndufv2 -7248 -7620
Ndufv3 1170 524
Nubpl -7141 -4162
Timmdc1 -802 127
Tmem126b -3311 -2414
Tmem186 6858 6726



ACTIVATION OF SMO

ACTIVATION OF SMO
metric value
setSize 16
pMANOVA 0.0263
p.adjustMANOVA 0.0915
s.dist 0.513
s.LPS 0.358
s.OVA 0.367
p.LPS 0.0132
p.OVA 0.0109




Top 20 genes
Gene LPS OVA
Evc 8801 8899
Arrb1 8562 9089
Gas8 8157 8449
Iqce 8325 6430
Kif3a 8294 6014
Ptch1 7202 6037
Arrb2 7670 3686
Smo 3062 6977
Evc2 4863 3384
Cdon 1096 4337
Efcab7 819 271

Click HERE to show all gene set members

All member genes
LPS OVA
Arrb1 8562 9089
Arrb2 7670 3686
Boc -2213 -49
Cdon 1096 4337
Csnk1a1 -6830 -6406
Efcab7 819 271
Evc 8801 8899
Evc2 4863 3384
Gas1 -101 -76
Gas8 8157 8449
Grk2 -836 2563
Iqce 8325 6430
Kif3a 8294 6014
Ptch1 7202 6037
Shh -3432 -762
Smo 3062 6977



SYNAPTIC ADHESION LIKE MOLECULES

SYNAPTIC ADHESION LIKE MOLECULES
metric value
setSize 21
pMANOVA 0.00792
p.adjustMANOVA 0.0362
s.dist 0.504
s.LPS 0.389
s.OVA 0.321
p.LPS 0.00205
p.OVA 0.0109




Top 20 genes
Gene LPS OVA
Ptprf 8141 8673
Lrfn4 7206 8086
Grin2d 7882 7197
Dlg4 6134 8965
Grin2b 6672 7727
Ptprs 8425 5589
Lrfn3 5165 8317
Flot2 5543 7412
Grin1 7273 5560
Lrfn1 6801 4757
Lrfn2 3864 7765
Gria1 3571 5930
Flot1 2102 6653

Click HERE to show all gene set members

All member genes
LPS OVA
Dlg1 -6923 -5872
Dlg3 -137 5096
Dlg4 6134 8965
Flot1 2102 6653
Flot2 5543 7412
Gria1 3571 5930
Gria3 -3662 -7912
Gria4 711 -3297
Grin1 7273 5560
Grin2a 4883 -458
Grin2b 6672 7727
Grin2c 2534 -5733
Grin2d 7882 7197
Lrfn1 6801 4757
Lrfn2 3864 7765
Lrfn3 5165 8317
Lrfn4 7206 8086
Ptprd 5905 -601
Ptprf 8141 8673
Ptprs 8425 5589
Rtn3 -6364 -5063



RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
metric value
setSize 125
pMANOVA 1.45e-12
p.adjustMANOVA 2.44e-10
s.dist 0.504
s.LPS -0.353
s.OVA -0.359
p.LPS 9.86e-12
p.OVA 3.97e-12




Top 20 genes
Gene LPS OVA
Atp5c1 -8036 -7922
Ndufaf4 -7518 -7833
Atp5pb -7460 -7712
Ndufaf1 -7740 -7433
Dmac2l -7239 -7929
Ndufv2 -7248 -7620
Cycs -6806 -7995
Uqcrc2 -6971 -6908
Coq10b -7478 -6201
Ndufaf5 -6087 -7046
Etfa -6677 -6309
mt-Co2 -5501 -7646
Ndufc2 -6854 -5670
Uqcrfs1 -6258 -6206
Sdhb -6037 -6104
Ndufs4 -6153 -5964
mt-Nd6 -6506 -5625
Ndufb5 -5725 -6211
Etfdh -7098 -4870
Ndufaf2 -5918 -5834

Click HERE to show all gene set members

All member genes
LPS OVA
Acad9 -677 -2478
Atp5a1 -4467 -3463
Atp5b -4848 -5408
Atp5c1 -8036 -7922
Atp5d 317 -1641
Atp5e -1106 1068
Atp5g1 1337 396
Atp5g2 -3028 798
Atp5g3 -4423 -3683
Atp5h -4775 -5491
Atp5j -1090 -1383
Atp5j2 -1497 -2315
Atp5k 2026 2297
Atp5l -4647 -6085
Atp5o -4661 -6181
Atp5pb -7460 -7712
Coq10a -2669 -4035
Coq10b -7478 -6201
Cox11 -2192 -880
Cox14 -2673 -4176
Cox16 -3224 -7097
Cox18 -1085 1678
Cox19 1626 1226
Cox20 -1698 -992
Cox4i1 -2474 -2071
Cox5a -4253 -5811
Cox5b 1144 1275
Cox6a1 -2751 -2367
Cox6b1 -3826 -4348
Cox6c -1376 -973
Cox7a2l -4676 -2372
Cox7b -3286 -5541
Cox7c -2914 -2009
Cox8a -1251 2958
Cyc1 -4060 -4414
Cycs -6806 -7995
Dmac2l -7239 -7929
Ecsit -2853 -792
Etfa -6677 -6309
Etfb -4034 923
Etfdh -7098 -4870
Lrpprc 2463 -2246
mt-Atp6 -5033 -4674
mt-Atp8 7204 8275
mt-Co1 -5609 -2352
mt-Co2 -5501 -7646
mt-Co3 -5091 -5245
mt-Cytb -5464 -3495
mt-Nd1 -5959 -4808
mt-Nd2 -7018 -4746
mt-Nd3 254 4569
mt-Nd4 -6158 -3933
mt-Nd5 -5883 -1883
mt-Nd6 -6506 -5625
Ndufa1 -459 -969
Ndufa10 -4264 -6584
Ndufa11 -3098 -4609
Ndufa12 3430 814
Ndufa13 1607 3362
Ndufa2 -1508 192
Ndufa3 1785 2432
Ndufa4 -3802 -4264
Ndufa5 -1322 -2826
Ndufa6 -550 -725
Ndufa7 -2619 673
Ndufa8 -1957 -884
Ndufa9 -2826 -4055
Ndufab1 -4234 -5870
Ndufaf1 -7740 -7433
Ndufaf2 -5918 -5834
Ndufaf3 -1229 1625
Ndufaf4 -7518 -7833
Ndufaf5 -6087 -7046
Ndufaf6 356 -5557
Ndufaf7 1828 4134
Ndufb1 -1089 286
Ndufb10 -2923 -5202
Ndufb11 -4941 -4738
Ndufb2 -2450 -3680
Ndufb3 -4203 -3443
Ndufb4 -4219 -1828
Ndufb5 -5725 -6211
Ndufb6 -3321 -5436
Ndufb7 -637 522
Ndufb8 -3888 -3598
Ndufb9 -4205 -3191
Ndufc1 -2328 -3137
Ndufc2 -6854 -5670
Ndufs1 -5615 -5618
Ndufs2 -2560 -313
Ndufs3 -4323 -5088
Ndufs4 -6153 -5964
Ndufs5 -2817 -4378
Ndufs6 983 965
Ndufs7 1862 536
Ndufs8 -4515 -6310
Ndufv1 -1535 -1886
Ndufv2 -7248 -7620
Ndufv3 1170 524
Nubpl -7141 -4162
Pm20d1 5183 2494
Sco1 -5118 -6137
Sco2 -8317 -39
Sdha -732 1601
Sdhb -6037 -6104
Sdhc -5010 -1445
Sdhd -5537 -2712
Slc25a14 -1539 1011
Slc25a27 5942 1690
Surf1 -4280 -3080
Taco1 748 -2332
Timmdc1 -802 127
Tmem126b -3311 -2414
Tmem186 6858 6726
Trap1 4891 -870
Ucp2 6396 8737
Ucp3 -398 -4732
Uqcr10 649 1013
Uqcr11 -113 1026
Uqcrb -3702 -3671
Uqcrc1 -1843 -2143
Uqcrc2 -6971 -6908
Uqcrfs1 -6258 -6206
Uqcrh -4394 -3922
Uqcrq -1273 -45



GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION

GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
metric value
setSize 31
pMANOVA 0.00106
p.adjustMANOVA 0.00766
s.dist 0.5
s.LPS -0.376
s.OVA -0.329
p.LPS 0.000291
p.OVA 0.00151




Top 20 genes
Gene LPS OVA
Cdc42 -7980 -7658
Mtap -7869 -7535
Capza1 -7237 -6957
Tcp1 -7344 -6682
Hnrnpdl -6857 -6934
Rap1b -7561 -6216
Rala -5838 -5759
Taldo1 -6826 -4799
Ppia -5315 -5772
Arf1 -5496 -3807
Gsto1 -7774 -2470
Pitpna -2965 -5575
Cfl1 -3095 -5288
Lcp1 -2055 -7342
Hspa9 -3309 -2548
Psme2 -4086 -1733
Snrpa1 -2366 -2623
Hnrnpa2b1 -961 -5207
Aip -2274 -1868
Pdcd4 -2784 -1418

Click HERE to show all gene set members

All member genes
LPS OVA
Aip -2274 -1868
Anxa2 6787 5587
Arf1 -5496 -3807
Bola2 321 1062
Capza1 -7237 -6957
Cdc42 -7980 -7658
Cfl1 -3095 -5288
Cnn2 2167 2270
Gsto1 -7774 -2470
Hnrnpa2b1 -961 -5207
Hnrnpdl -6857 -6934
Hnrnpf -994 7227
Hspa9 -3309 -2548
Lcp1 -2055 -7342
Lmnb1 7 5695
Mif 1942 -789
Msn 4042 3611
Mtap -7869 -7535
Pak2 -4811 -23
Pdcd4 -2784 -1418
Pitpna -2965 -5575
Ppia -5315 -5772
Psme2 -4086 -1733
Rala -5838 -5759
Rap1b -7561 -6216
Rplp0 -3828 -225
Snrpa1 -2366 -2623
Sod1 389 1377
Sod2 1679 478
Taldo1 -6826 -4799
Tcp1 -7344 -6682



MITOCHONDRIAL PROTEIN IMPORT

MITOCHONDRIAL PROTEIN IMPORT
metric value
setSize 63
pMANOVA 1.38e-06
p.adjustMANOVA 3.3e-05
s.dist 0.498
s.LPS -0.347
s.OVA -0.357
p.LPS 1.88e-06
p.OVA 9.49e-07




Top 20 genes
Gene LPS OVA
Mtx2 -7994 -7766
Timm8a1 -7093 -7627
Tomm70a -7663 -6974
Pmpcb -7156 -6748
Timm23 -6976 -6678
Timm21 -6397 -7027
Slc25a4 -6615 -6551
Cmc4 -5596 -7601
Hspd1 -6227 -5851
Slc25a13 -7125 -5074
Chchd5 -5011 -6326
Tomm22 -6240 -4953
Grpel2 -6028 -4983
Atp5b -4848 -5408
Chchd3 -4600 -5336
Tomm20 -6633 -3658
Chchd2 -4455 -5078
Cmc2 -3283 -6322
Vdac1 -4594 -4104
Cyc1 -4060 -4414

Click HERE to show all gene set members

All member genes
LPS OVA
Aco2 78 -3932
Atp5a1 -4467 -3463
Atp5b -4848 -5408
Atp5g1 1337 396
Bcs1l 7055 3541
Chchd10 -1615 -1792
Chchd2 -4455 -5078
Chchd3 -4600 -5336
Chchd4 -3953 -2279
Chchd5 -5011 -6326
Chchd7 -2583 -5464
Cmc2 -3283 -6322
Cmc4 -5596 -7601
Coa4 -1133 918
Coa6 -4917 -388
Coq2 -3427 3934
Cox17 922 1165
Cox19 1626 1226
Cs -429 -686
Cyc1 -4060 -4414
Dnajc19 -1259 -2219
Fxn -2819 -4361
Gfer -2821 413
Grpel1 -4656 11
Grpel2 -6028 -4983
Hscb -4166 -400
Hspa9 -3309 -2548
Hspd1 -6227 -5851
Idh3g 805 -6070
Ldhd 3090 -2149
Mtx1 -5695 279
Mtx2 -7994 -7766
Ndufb8 -3888 -3598
Pam16 1309 907
Pitrm1 2055 -1874
Pmpca -2197 -1835
Pmpcb -7156 -6748
Samm50 893 145
Slc25a12 1762 1
Slc25a13 -7125 -5074
Slc25a4 -6615 -6551
Taz 4810 -2853
Timm10 -3877 -412
Timm10b -3125 -2304
Timm13 505 1366
Timm17a -1488 -1431
Timm17b -2943 1082
Timm21 -6397 -7027
Timm22 -2245 2565
Timm23 -6976 -6678
Timm44 -367 -5721
Timm50 -3306 -3326
Timm8a1 -7093 -7627
Timm8b -1901 -2152
Timm9 -2931 -4904
Tomm20 -6633 -3658
Tomm22 -6240 -4953
Tomm40 2435 5440
Tomm5 -2459 -1768
Tomm6 -1220 2794
Tomm7 -2498 -718
Tomm70a -7663 -6974
Vdac1 -4594 -4104



ASSEMBLY OF THE PRE REPLICATIVE COMPLEX

ASSEMBLY OF THE PRE REPLICATIVE COMPLEX
metric value
setSize 65
pMANOVA 3.41e-07
p.adjustMANOVA 9.78e-06
s.dist 0.495
s.LPS -0.391
s.OVA -0.304
p.LPS 5.16e-08
p.OVA 2.2e-05




Top 20 genes
Gene LPS OVA
Psmc6 -8164 -8078
Orc5 -7766 -7983
Psmd12 -7838 -7875
Psmd14 -7925 -7511
Orc6 -7733 -7614
Orc4 -7332 -7976
Psma2 -7138 -7161
Psma1 -6516 -7401
Psma6 -7540 -6288
Psmd6 -7133 -5840
Psmd8 -6155 -6636
Psmd10 -5459 -6231
Psmb7 -5363 -6301
Mcm3 -7024 -4767
Psmb1 -5468 -5925
Psma5 -5762 -5255
Psma4 -4778 -6092
E2f2 -6937 -4119
Psmf1 -6993 -3727
Psmc2 -5026 -4433

Click HERE to show all gene set members

All member genes
LPS OVA
Cdt1 -1081 -2222
E2f1 3805 -285
E2f2 -6937 -4119
E2f3 -4076 -3622
Gmnn -580 -2254
Mcm2 -30 6274
Mcm3 -7024 -4767
Mcm4 -4042 -4191
Mcm5 -3584 3580
Mcm6 -1082 2561
Mcm7 438 3388
Mcm8 -2225 1086
Orc2 -5769 -3286
Orc3 -1276 -4855
Orc4 -7332 -7976
Orc5 -7766 -7983
Orc6 -7733 -7614
Psma1 -6516 -7401
Psma2 -7138 -7161
Psma3 -4482 -2445
Psma4 -4778 -6092
Psma5 -5762 -5255
Psma6 -7540 -6288
Psma7 -3945 -2499
Psma8 -3850 -5256
Psmb1 -5468 -5925
Psmb10 -2128 1135
Psmb2 -1614 316
Psmb3 -4555 -3060
Psmb4 -1460 2693
Psmb5 722 2001
Psmb6 -1637 -229
Psmb7 -5363 -6301
Psmb8 -6149 3823
Psmb9 -7822 184
Psmc1 -1668 -3102
Psmc2 -5026 -4433
Psmc3 -2318 -4842
Psmc4 120 297
Psmc5 -1532 -5723
Psmc6 -8164 -8078
Psmd1 1038 -270
Psmd10 -5459 -6231
Psmd11 -126 -1140
Psmd12 -7838 -7875
Psmd13 -2419 -2577
Psmd14 -7925 -7511
Psmd2 3302 1444
Psmd3 2878 3397
Psmd4 2222 2428
Psmd5 -4568 -3144
Psmd6 -7133 -5840
Psmd7 1440 3146
Psmd8 -6155 -6636
Psmd9 -3301 6883
Psme1 704 7691
Psme2 -4086 -1733
Psme3 -2344 -1577
Psme4 3537 -3560
Psmf1 -6993 -3727
Rps27a -4089 -1699
Sem1 -2402 -2337
Uba52 3633 5393
Ubb -4186 -2003
Ubc 3428 795



ORC1 REMOVAL FROM CHROMATIN

ORC1 REMOVAL FROM CHROMATIN
metric value
setSize 68
pMANOVA 4.81e-07
p.adjustMANOVA 1.26e-05
s.dist 0.493
s.LPS -0.37
s.OVA -0.326
p.LPS 1.35e-07
p.OVA 3.41e-06




Top 20 genes
Gene LPS OVA
Psmc6 -8164 -8078
Orc5 -7766 -7983
Psmd12 -7838 -7875
Psmd14 -7925 -7511
Orc6 -7733 -7614
Orc4 -7332 -7976
Skp1 -7724 -7530
Cul1 -7411 -7232
Psma2 -7138 -7161
Psma1 -6516 -7401
Psma6 -7540 -6288
Psmd6 -7133 -5840
Psmd8 -6155 -6636
Psmd10 -5459 -6231
Psmb7 -5363 -6301
Mcm3 -7024 -4767
Psmb1 -5468 -5925
Psma5 -5762 -5255
Psma4 -4778 -6092
Psmf1 -6993 -3727

Click HERE to show all gene set members

All member genes
LPS OVA
Ccna1 3395 542
Ccna2 5358 -4215
Cdk2 6623 -3919
Cdt1 -1081 -2222
Cul1 -7411 -7232
Mcm2 -30 6274
Mcm3 -7024 -4767
Mcm4 -4042 -4191
Mcm5 -3584 3580
Mcm6 -1082 2561
Mcm7 438 3388
Mcm8 -2225 1086
Orc2 -5769 -3286
Orc3 -1276 -4855
Orc4 -7332 -7976
Orc5 -7766 -7983
Orc6 -7733 -7614
Psma1 -6516 -7401
Psma2 -7138 -7161
Psma3 -4482 -2445
Psma4 -4778 -6092
Psma5 -5762 -5255
Psma6 -7540 -6288
Psma7 -3945 -2499
Psma8 -3850 -5256
Psmb1 -5468 -5925
Psmb10 -2128 1135
Psmb2 -1614 316
Psmb3 -4555 -3060
Psmb4 -1460 2693
Psmb5 722 2001
Psmb6 -1637 -229
Psmb7 -5363 -6301
Psmb8 -6149 3823
Psmb9 -7822 184
Psmc1 -1668 -3102
Psmc2 -5026 -4433
Psmc3 -2318 -4842
Psmc4 120 297
Psmc5 -1532 -5723
Psmc6 -8164 -8078
Psmd1 1038 -270
Psmd10 -5459 -6231
Psmd11 -126 -1140
Psmd12 -7838 -7875
Psmd13 -2419 -2577
Psmd14 -7925 -7511
Psmd2 3302 1444
Psmd3 2878 3397
Psmd4 2222 2428
Psmd5 -4568 -3144
Psmd6 -7133 -5840
Psmd7 1440 3146
Psmd8 -6155 -6636
Psmd9 -3301 6883
Psme1 704 7691
Psme2 -4086 -1733
Psme3 -2344 -1577
Psme4 3537 -3560
Psmf1 -6993 -3727
Rbx1 -4690 -4712
Rps27a -4089 -1699
Sem1 -2402 -2337
Skp1 -7724 -7530
Skp2 -439 -1946
Uba52 3633 5393
Ubb -4186 -2003
Ubc 3428 795



SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE

SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
metric value
setSize 87
pMANOVA 6.28e-09
p.adjustMANOVA 2.64e-07
s.dist 0.493
s.LPS -0.376
s.OVA -0.318
p.LPS 1.33e-09
p.OVA 2.86e-07




Top 20 genes
Gene LPS OVA
Psmc6 -8164 -8078
Ccne2 -8177 -8050
Ube2d1 -8181 -7637
Orc5 -7766 -7983
Psmd12 -7838 -7875
Ube2e1 -7933 -7579
Psmd14 -7925 -7511
Anapc10 -7408 -8014
Orc6 -7733 -7614
Orc4 -7332 -7976
Skp1 -7724 -7530
Cul1 -7411 -7232
Psma2 -7138 -7161
Psma1 -6516 -7401
Psma6 -7540 -6288
Psmd6 -7133 -5840
Psmd8 -6155 -6636
Cdc26 -6690 -5810
Cdc16 -6443 -5490
Psmd10 -5459 -6231

Click HERE to show all gene set members

All member genes
LPS OVA
Anapc1 5734 6018
Anapc10 -7408 -8014
Anapc11 -2230 2052
Anapc15 -2429 -3318
Anapc16 -4000 2437
Anapc2 7262 8061
Anapc4 -3066 -5639
Anapc5 5857 -536
Anapc7 -4484 1863
Ccna1 3395 542
Ccna2 5358 -4215
Ccne1 -3649 -3626
Ccne2 -8177 -8050
Cdc16 -6443 -5490
Cdc23 -3423 3026
Cdc26 -6690 -5810
Cdc27 -4993 -4307
Cdk2 6623 -3919
Cdt1 -1081 -2222
Cul1 -7411 -7232
Fzr1 -989 2317
Mcm2 -30 6274
Mcm3 -7024 -4767
Mcm4 -4042 -4191
Mcm5 -3584 3580
Mcm6 -1082 2561
Mcm7 438 3388
Mcm8 -2225 1086
Orc2 -5769 -3286
Orc3 -1276 -4855
Orc4 -7332 -7976
Orc5 -7766 -7983
Orc6 -7733 -7614
Psma1 -6516 -7401
Psma2 -7138 -7161
Psma3 -4482 -2445
Psma4 -4778 -6092
Psma5 -5762 -5255
Psma6 -7540 -6288
Psma7 -3945 -2499
Psma8 -3850 -5256
Psmb1 -5468 -5925
Psmb10 -2128 1135
Psmb2 -1614 316
Psmb3 -4555 -3060
Psmb4 -1460 2693
Psmb5 722 2001
Psmb6 -1637 -229
Psmb7 -5363 -6301
Psmb8 -6149 3823
Psmb9 -7822 184
Psmc1 -1668 -3102
Psmc2 -5026 -4433
Psmc3 -2318 -4842
Psmc4 120 297
Psmc5 -1532 -5723
Psmc6 -8164 -8078
Psmd1 1038 -270
Psmd10 -5459 -6231
Psmd11 -126 -1140
Psmd12 -7838 -7875
Psmd13 -2419 -2577
Psmd14 -7925 -7511
Psmd2 3302 1444
Psmd3 2878 3397
Psmd4 2222 2428
Psmd5 -4568 -3144
Psmd6 -7133 -5840
Psmd7 1440 3146
Psmd8 -6155 -6636
Psmd9 -3301 6883
Psme1 704 7691
Psme2 -4086 -1733
Psme3 -2344 -1577
Psme4 3537 -3560
Psmf1 -6993 -3727
Rbx1 -4690 -4712
Rps27a -4089 -1699
Sem1 -2402 -2337
Skp1 -7724 -7530
Skp2 -439 -1946
Uba52 3633 5393
Ubb -4186 -2003
Ubc 3428 795
Ube2d1 -8181 -7637
Ube2e1 -7933 -7579
Ube2s -4614 -3396



GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
metric value
setSize 12
pMANOVA 0.0512
p.adjustMANOVA 0.149
s.dist 0.491
s.LPS -0.405
s.OVA -0.278
p.LPS 0.015
p.OVA 0.0959




Top 20 genes
Gene LPS OVA
Rab2a -8285 -7769
Blzf1 -7245 -7379
Rab1a -7360 -6910
Cdk1 -6950 -4504
Uso1 -5292 -5375
Mapk1 -6064 -4480
Mapk3 -5102 -1666
Plk1 -330 -712
Gorasp2 -4145 -47

Click HERE to show all gene set members

All member genes
LPS OVA
Blzf1 -7245 -7379
Cdk1 -6950 -4504
Golga2 8579 8782
Gorasp1 6170 6337
Gorasp2 -4145 -47
Mapk1 -6064 -4480
Mapk3 -5102 -1666
Plk1 -330 -712
Rab1a -7360 -6910
Rab1b -2783 1180
Rab2a -8285 -7769
Uso1 -5292 -5375



METABOLISM OF POLYAMINES

METABOLISM OF POLYAMINES
metric value
setSize 58
pMANOVA 1.56e-06
p.adjustMANOVA 3.53e-05
s.dist 0.489
s.LPS -0.393
s.OVA -0.292
p.LPS 2.33e-07
p.OVA 0.000122




Top 20 genes
Gene LPS OVA
Psmc6 -8164 -8078
Psmd12 -7838 -7875
Psmd14 -7925 -7511
Sms -7722 -7506
Psma2 -7138 -7161
Psma1 -6516 -7401
Psma6 -7540 -6288
Azin1 -6538 -6827
Amd1 -7547 -5632
Psmd6 -7133 -5840
Psmd8 -6155 -6636
Psmd10 -5459 -6231
Psmb7 -5363 -6301
Psmb1 -5468 -5925
Psma5 -5762 -5255
Psma4 -4778 -6092
Sat1 -4090 -6484
Psmf1 -6993 -3727
Psmc2 -5026 -4433
Psma8 -3850 -5256

Click HERE to show all gene set members

All member genes
LPS OVA
Agmat 1845 -6193
Amd1 -7547 -5632
Azin1 -6538 -6827
Azin2 -397 5434
Nqo1 -7852 -1942
Oaz1 -1496 1634
Oaz2 -3920 5
Oaz3 6186 7862
Odc1 -4294 -158
Paox -5430 -438
Psma1 -6516 -7401
Psma2 -7138 -7161
Psma3 -4482 -2445
Psma4 -4778 -6092
Psma5 -5762 -5255
Psma6 -7540 -6288
Psma7 -3945 -2499
Psma8 -3850 -5256
Psmb1 -5468 -5925
Psmb10 -2128 1135
Psmb2 -1614 316
Psmb3 -4555 -3060
Psmb4 -1460 2693
Psmb5 722 2001
Psmb6 -1637 -229
Psmb7 -5363 -6301
Psmb8 -6149 3823
Psmb9 -7822 184
Psmc1 -1668 -3102
Psmc2 -5026 -4433
Psmc3 -2318 -4842
Psmc4 120 297
Psmc5 -1532 -5723
Psmc6 -8164 -8078
Psmd1 1038 -270
Psmd10 -5459 -6231
Psmd11 -126 -1140
Psmd12 -7838 -7875
Psmd13 -2419 -2577
Psmd14 -7925 -7511
Psmd2 3302 1444
Psmd3 2878 3397
Psmd4 2222 2428
Psmd5 -4568 -3144
Psmd6 -7133 -5840
Psmd7 1440 3146
Psmd8 -6155 -6636
Psmd9 -3301 6883
Psme1 704 7691
Psme2 -4086 -1733
Psme3 -2344 -1577
Psme4 3537 -3560
Psmf1 -6993 -3727
Sat1 -4090 -6484
Sem1 -2402 -2337
Smox 8655 9015
Sms -7722 -7506
Srm -4298 -1622



NEGATIVE REGULATION OF NOTCH4 SIGNALING

NEGATIVE REGULATION OF NOTCH4 SIGNALING
metric value
setSize 54
pMANOVA 4.01e-06
p.adjustMANOVA 8.58e-05
s.dist 0.488
s.LPS -0.392
s.OVA -0.291
p.LPS 6.2e-07
p.OVA 0.000217




Top 20 genes
Gene LPS OVA
Psmc6 -8164 -8078
Psmd12 -7838 -7875
Psmd14 -7925 -7511
Skp1 -7724 -7530
Cul1 -7411 -7232
Psma2 -7138 -7161
Psma1 -6516 -7401
Psma6 -7540 -6288
Psmd6 -7133 -5840
Psmd8 -6155 -6636
Psmd10 -5459 -6231
Psmb7 -5363 -6301
Psmb1 -5468 -5925
Fbxw7 -4306 -7129
Psma5 -5762 -5255
Psma4 -4778 -6092
Psmf1 -6993 -3727
Psmc2 -5026 -4433
Rbx1 -4690 -4712
Ywhaz -6933 -2916

Click HERE to show all gene set members

All member genes
LPS OVA
Akt1 436 3808
Cul1 -7411 -7232
Fbxw7 -4306 -7129
Notch4 8781 8586
Psma1 -6516 -7401
Psma2 -7138 -7161
Psma3 -4482 -2445
Psma4 -4778 -6092
Psma5 -5762 -5255
Psma6 -7540 -6288
Psma7 -3945 -2499
Psmb1 -5468 -5925
Psmb10 -2128 1135
Psmb2 -1614 316
Psmb3 -4555 -3060
Psmb4 -1460 2693
Psmb5 722 2001
Psmb6 -1637 -229
Psmb7 -5363 -6301
Psmb8 -6149 3823
Psmb9 -7822 184
Psmc1 -1668 -3102
Psmc2 -5026 -4433
Psmc3 -2318 -4842
Psmc4 120 297
Psmc5 -1532 -5723
Psmc6 -8164 -8078
Psmd1 1038 -270
Psmd10 -5459 -6231
Psmd11 -126 -1140
Psmd12 -7838 -7875
Psmd13 -2419 -2577
Psmd14 -7925 -7511
Psmd2 3302 1444
Psmd3 2878 3397
Psmd4 2222 2428
Psmd5 -4568 -3144
Psmd6 -7133 -5840
Psmd7 1440 3146
Psmd8 -6155 -6636
Psmd9 -3301 6883
Psme1 704 7691
Psme2 -4086 -1733
Psme3 -2344 -1577
Psmf1 -6993 -3727
Rbx1 -4690 -4712
Rps27a -4089 -1699
Sem1 -2402 -2337
Skp1 -7724 -7530
Tacc3 -1565 1301
Uba52 3633 5393
Ubb -4186 -2003
Ubc 3428 795
Ywhaz -6933 -2916



RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY
metric value
setSize 11
pMANOVA 0.0694
p.adjustMANOVA 0.181
s.dist 0.486
s.LPS -0.401
s.OVA -0.274
p.LPS 0.0213
p.OVA 0.116




Top 20 genes
Gene LPS OVA
Fundc1 -7969 -7901
Atg5 -7797 -7729
Atg12 -8165 -4949
Pgam5 -6769 -4372
Map1lc3b -4623 -5168
Csnk2a2 -5289 -2889
Map1lc3a -840 -696
Csnk2b -4311 -125

Click HERE to show all gene set members

All member genes
LPS OVA
Atg12 -8165 -4949
Atg5 -7797 -7729
Csnk2a1 -2155 1228
Csnk2a2 -5289 -2889
Csnk2b -4311 -125
Fundc1 -7969 -7901
Map1lc3a -840 -696
Map1lc3b -4623 -5168
Pgam5 -6769 -4372
Src 5353 7945
Ulk1 7400 4355



CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
metric value
setSize 47
pMANOVA 2.82e-05
p.adjustMANOVA 0.000481
s.dist 0.485
s.LPS -0.386
s.OVA -0.295
p.LPS 4.82e-06
p.OVA 0.000467




Top 20 genes
Gene LPS OVA
Psmc6 -8164 -8078
Psmd12 -7838 -7875
Psmd14 -7925 -7511
Psma2 -7138 -7161
Psma1 -6516 -7401
Psma6 -7540 -6288
Psmd6 -7133 -5840
Psmd8 -6155 -6636
Psmd10 -5459 -6231
Psmb7 -5363 -6301
Psmb1 -5468 -5925
Psma5 -5762 -5255
Psma4 -4778 -6092
Psmf1 -6993 -3727
Psmc2 -5026 -4433
Psma8 -3850 -5256
Psmd5 -4568 -3144
Psmb3 -4555 -3060
Psmc3 -2318 -4842
Psma3 -4482 -2445

Click HERE to show all gene set members

All member genes
LPS OVA
Fcgr1 -5345 16
Mrc1 -1861 -945
Mrc2 7288 8613
Psma1 -6516 -7401
Psma2 -7138 -7161
Psma3 -4482 -2445
Psma4 -4778 -6092
Psma5 -5762 -5255
Psma6 -7540 -6288
Psma7 -3945 -2499
Psma8 -3850 -5256
Psmb1 -5468 -5925
Psmb10 -2128 1135
Psmb2 -1614 316
Psmb3 -4555 -3060
Psmb4 -1460 2693
Psmb5 722 2001
Psmb6 -1637 -229
Psmb7 -5363 -6301
Psmb8 -6149 3823
Psmb9 -7822 184
Psmc1 -1668 -3102
Psmc2 -5026 -4433
Psmc3 -2318 -4842
Psmc4 120 297
Psmc5 -1532 -5723
Psmc6 -8164 -8078
Psmd1 1038 -270
Psmd10 -5459 -6231
Psmd11 -126 -1140
Psmd12 -7838 -7875
Psmd13 -2419 -2577
Psmd14 -7925 -7511
Psmd2 3302 1444
Psmd3 2878 3397
Psmd4 2222 2428
Psmd5 -4568 -3144
Psmd6 -7133 -5840
Psmd7 1440 3146
Psmd8 -6155 -6636
Psmd9 -3301 6883
Psme1 704 7691
Psme2 -4086 -1733
Psme3 -2344 -1577
Psme4 3537 -3560
Psmf1 -6993 -3727
Sem1 -2402 -2337



RETINOID CYCLE DISEASE EVENTS

RETINOID CYCLE DISEASE EVENTS
metric value
setSize 10
pMANOVA 0.000457
p.adjustMANOVA 0.00401
s.dist 0.485
s.LPS -0.485
s.OVA 0.00193
p.LPS 0.00798
p.OVA 0.992




Top 20 genes
Gene LPS OVA
Rbp1 -3582 5248
Stra6 -8185 696

Click HERE to show all gene set members

All member genes
LPS OVA
Abca4 -8123 -2142
Lrat 781 -552
Napepld -5176 -1148
Rbp1 -3582 5248
Rbp4 2206 3991
Rdh12 -4983 -3962
Rdh5 -6198 -1310
Rlbp1 1472 7422
Stra6 -8185 696
Ttr -7369 -2947



APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION
metric value
setSize 10
pMANOVA 0.11
p.adjustMANOVA 0.244
s.dist 0.484
s.LPS -0.295
s.OVA -0.383
p.LPS 0.106
p.OVA 0.0359




Top 20 genes
Gene LPS OVA
H1f0 -7839 -7528
Kpna1 -6863 -6638
Hmgb1 -6597 -5638
H1f2 -7903 -3873
Hmgb2 -8094 -3773

Click HERE to show all gene set members

All member genes
LPS OVA
Casp3 1555 -1246
Dffa 4523 -3373
Dffb 4067 -3547
H1f0 -7839 -7528
H1f2 -7903 -3873
H1f4 1402 3416
Hmgb1 -6597 -5638
Hmgb2 -8094 -3773
Kpna1 -6863 -6638
Kpnb1 2909 4309



Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.3.1 (2023-06-16)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so;  LAPACK version 3.10.0
## 
## locale:
##  [1] LC_CTYPE=en_AU.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_AU.UTF-8        LC_COLLATE=en_AU.UTF-8    
##  [5] LC_MONETARY=en_AU.UTF-8    LC_MESSAGES=en_AU.UTF-8   
##  [7] LC_PAPER=en_AU.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_AU.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: /usr/share/zoneinfo/Australia/Melbourne
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] GGally_2.1.2                gtools_3.9.4               
##  [3] echarts4r_0.4.5             beeswarm_0.4.0             
##  [5] pkgload_1.3.2.1             vioplot_0.4.0              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.16.0          limma_3.56.2               
## [11] eulerr_7.0.0                mitch_1.12.0               
## [13] MASS_7.3-60                 fgsea_1.26.0               
## [15] gplots_3.1.3                DESeq2_1.40.2              
## [17] SummarizedExperiment_1.30.2 Biobase_2.60.0             
## [19] MatrixGenerics_1.12.3       matrixStats_1.0.0          
## [21] GenomicRanges_1.52.0        GenomeInfoDb_1.36.2        
## [23] IRanges_2.34.1              S4Vectors_0.38.1           
## [25] BiocGenerics_0.46.0         reshape2_1.4.4             
## [27] lubridate_1.9.2             forcats_1.0.0              
## [29] stringr_1.5.0               dplyr_1.1.2                
## [31] purrr_1.0.2                 readr_2.1.4                
## [33] tidyr_1.3.0                 tibble_3.2.1               
## [35] ggplot2_3.4.3               tidyverse_2.0.0            
## [37] zoo_1.8-12                 
## 
## loaded via a namespace (and not attached):
##  [1] bitops_1.0-7            gridExtra_2.3           rlang_1.1.1            
##  [4] magrittr_2.0.3          compiler_4.3.1          polylabelr_0.2.0       
##  [7] systemfonts_1.0.4       vctrs_0.6.3             rvest_1.0.3            
## [10] pkgconfig_2.0.3         crayon_1.5.2            fastmap_1.1.1          
## [13] XVector_0.40.0          ellipsis_0.3.2          labeling_0.4.2         
## [16] caTools_1.18.2          utf8_1.2.3              promises_1.2.1         
## [19] rmarkdown_2.24          tzdb_0.4.0              xfun_0.40              
## [22] zlibbioc_1.46.0         cachem_1.0.8            jsonlite_1.8.7         
## [25] highr_0.10              later_1.3.1             DelayedArray_0.26.7    
## [28] reshape_0.8.9           BiocParallel_1.34.2     parallel_4.3.1         
## [31] R6_2.5.1                bslib_0.5.1             stringi_1.7.12         
## [34] RColorBrewer_1.1-3      jquerylib_0.1.4         assertthat_0.2.1       
## [37] Rcpp_1.0.11             knitr_1.43              httpuv_1.6.11          
## [40] Matrix_1.6-1            timechange_0.2.0        tidyselect_1.2.0       
## [43] rstudioapi_0.15.0       abind_1.4-5             yaml_2.3.7             
## [46] codetools_0.2-19        lattice_0.21-8          plyr_1.8.8             
## [49] shiny_1.7.5             withr_2.5.0             evaluate_0.21          
## [52] polyclip_1.10-4         xml2_1.3.5              pillar_1.9.0           
## [55] KernSmooth_2.23-22      generics_0.1.3          RCurl_1.98-1.12        
## [58] hms_1.1.3               munsell_0.5.0           scales_1.2.1           
## [61] xtable_1.8-4            glue_1.6.2              tools_4.3.1            
## [64] data.table_1.14.8       webshot_0.5.5           locfit_1.5-9.8         
## [67] fastmatch_1.1-4         cowplot_1.1.1           grid_4.3.1             
## [70] colorspace_2.1-0        GenomeInfoDbData_1.2.10 cli_3.6.1              
## [73] fansi_1.0.4             viridisLite_0.4.2       S4Arrays_1.0.5         
## [76] svglite_2.1.1           gtable_0.3.4            sass_0.4.7             
## [79] digest_0.6.33           farver_2.1.1            htmlwidgets_1.6.2      
## [82] htmltools_0.5.6         lifecycle_1.0.3         httr_1.4.7             
## [85] mime_0.12

END of report