Mitch Report

date generated: 2022-03-15

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                      LPS          OVA
## 0610009B22Rik  0.2684894  1.831236577
## 0610009E02Rik -0.7521235 -0.103702849
## 0610009L18Rik -1.1838923 -0.075637695
## 0610010K14Rik -0.0433030  0.417670579
## 0610012G03Rik -0.1930476  0.008709563
## 0610030E20Rik  1.0496464 -1.609523779

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genes_in_profile	16550
duplicated_genes_present	0
num_profile_genes_in_sets	8251
num_profile_genes_not_in_sets	8299
profile_pearson_correl	0.09156
profile_spearman_correl	0.0695

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	438
num_genesets_included	1166

Gene sets by quadrant

Number of significant gene sets (FDR<0.05)= 264

Interactive enrichment scatterplot

All sets with FDR<0.05. Try hovering over the points.

Top N sets irrespective of FDR. Try hovering over the points.

A heatmap of S values for top results

A plot of effect size versus significance

Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.

Results table

Top N= 50 gene sets

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.LPS	s.OVA	p.LPS	p.OVA
EUKARYOTIC TRANSLATION ELONGATION	87	3.59e-25	1.05e-22	0.680	0.44300	0.5150	9.24e-13	9.30e-17
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	8.53e-04	6.42e-03	0.658	0.07890	0.6540	6.50e-01	1.74e-04
MET ACTIVATES RAP1 AND RAC1	11	1.29e-03	8.88e-03	0.618	-0.56700	0.2450	1.12e-03	1.60e-01
COMPLEX I BIOGENESIS	56	1.26e-13	7.33e-12	0.612	0.29500	0.5360	1.33e-04	3.88e-12
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	1.66e-21	2.15e-19	0.603	0.38000	0.4680	1.94e-10	4.37e-15
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.27e-03	1.43e-02	0.601	0.37200	0.4720	2.57e-02	4.65e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	3.87e-23	6.45e-21	0.588	0.32400	0.4910	8.10e-09	2.38e-18
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	3.08e-05	4.27e-04	0.588	-0.22200	0.5450	9.34e-02	3.94e-05
INITIAL TRIGGERING OF COMPLEMENT	10	8.52e-03	3.96e-02	0.582	0.47400	0.3370	9.42e-03	6.49e-02
CD28 DEPENDENT VAV1 PATHWAY	10	4.58e-03	2.45e-02	0.578	-0.40900	0.4080	2.51e-02	2.53e-02
EUKARYOTIC TRANSLATION INITIATION	114	6.39e-23	9.31e-21	0.565	0.30600	0.4750	1.75e-08	1.98e-18
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	2.44e-03	1.49e-02	0.557	0.03560	0.5560	8.24e-01	5.24e-04
RESPIRATORY ELECTRON TRANSPORT	102	4.13e-20	4.38e-18	0.553	0.21000	0.5120	2.46e-04	3.92e-19
PINK1 PRKN MEDIATED MITOPHAGY	22	6.14e-05	7.38e-04	0.553	0.18800	0.5210	1.27e-01	2.36e-05
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	12	5.73e-03	2.83e-02	0.553	0.32000	0.4510	5.53e-02	6.81e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	9.83e-12	4.77e-10	0.551	0.27000	0.4800	3.32e-04	1.75e-10
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	4.65e-03	2.45e-02	0.551	-0.43200	0.3420	1.30e-02	4.97e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	4.86e-24	1.13e-21	0.549	0.21600	0.5050	3.17e-05	1.81e-22
COLLAGEN CHAIN TRIMERIZATION	39	9.52e-09	3.36e-07	0.543	0.42300	-0.3400	4.80e-06	2.40e-04
ASPARTATE AND ASPARAGINE METABOLISM	10	1.21e-02	5.23e-02	0.542	0.01360	0.5420	9.40e-01	2.99e-03
SHC MEDIATED CASCADE FGFR3	12	6.60e-03	3.20e-02	0.541	0.21400	0.4970	1.98e-01	2.90e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.52e-06	3.63e-05	0.540	-0.21600	0.4950	4.42e-02	3.90e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.77e-04	1.72e-03	0.535	-0.00703	0.5350	9.57e-01	3.43e-05
SELENOAMINO ACID METABOLISM	107	2.87e-19	2.78e-17	0.534	0.33200	0.4180	3.09e-09	7.55e-14
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	1.13e-02	4.97e-02	0.534	-0.18700	0.5000	3.06e-01	6.19e-03
SCAVENGING BY CLASS A RECEPTORS	13	5.54e-03	2.75e-02	0.532	0.44600	0.2910	5.40e-03	6.91e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	8.63e-03	3.98e-02	0.532	-0.53000	0.0488	2.34e-03	7.79e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	1.83e-02	6.99e-02	0.530	0.23100	0.4770	2.06e-01	8.98e-03
ACTIVATION OF RAC1	13	3.20e-03	1.84e-02	0.530	-0.49600	0.1850	1.95e-03	2.47e-01
TRIGLYCERIDE CATABOLISM	14	2.55e-03	1.54e-02	0.529	-0.05210	0.5260	7.36e-01	6.55e-04
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	15	2.65e-03	1.59e-02	0.525	0.19800	0.4870	1.85e-01	1.10e-03
PI 3K CASCADE FGFR3	12	8.60e-03	3.98e-02	0.525	0.18800	0.4910	2.60e-01	3.26e-03
SHC MEDIATED CASCADE FGFR4	10	1.76e-02	6.84e-02	0.524	0.08370	0.5170	6.47e-01	4.65e-03
FRS MEDIATED FGFR3 SIGNALING	14	3.89e-03	2.15e-02	0.523	0.15100	0.5010	3.27e-01	1.18e-03
COMPLEMENT CASCADE	22	2.31e-04	2.17e-03	0.521	0.34400	0.3910	5.24e-03	1.48e-03
FRS MEDIATED FGFR4 SIGNALING	12	7.96e-03	3.74e-02	0.519	0.03200	0.5180	8.48e-01	1.88e-03
CITRIC ACID CYCLE TCA CYCLE	22	1.67e-04	1.69e-03	0.519	0.09520	0.5100	4.40e-01	3.43e-05
CRMPS IN SEMA3A SIGNALING	16	1.82e-03	1.17e-02	0.517	-0.07660	-0.5110	5.96e-01	3.99e-04
NONSENSE MEDIATED DECAY NMD	109	4.07e-18	3.39e-16	0.513	0.35300	0.3720	2.01e-10	1.88e-11
PI 3K CASCADE FGFR4	10	2.03e-02	7.51e-02	0.512	0.05190	0.5100	7.76e-01	5.26e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS	13	5.16e-03	2.64e-02	0.510	-0.12500	0.4950	4.35e-01	2.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42	18	5.93e-04	4.70e-03	0.510	-0.22300	0.4590	1.02e-01	7.54e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	1.18e-03	8.37e-03	0.509	0.15700	0.4840	2.49e-01	3.73e-04
PLATELET SENSITIZATION BY LDL	15	3.41e-03	1.92e-02	0.505	0.05480	0.5020	7.13e-01	7.57e-04
RHOBTB3 ATPASE CYCLE	10	1.87e-02	7.05e-02	0.505	-0.14100	0.4850	4.40e-01	7.95e-03
GLYCOGEN STORAGE DISEASES	12	1.58e-02	6.32e-02	0.491	0.18600	0.4550	2.66e-01	6.37e-03
SEROTONIN RECEPTORS	10	2.08e-02	7.64e-02	0.491	-0.39300	0.2940	3.13e-02	1.07e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.20e-26	4.68e-24	0.491	0.14000	0.4710	1.59e-03	1.72e-26
DARPP 32 EVENTS	23	1.70e-04	1.70e-03	0.488	-0.20100	0.4450	9.54e-02	2.22e-04
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	4.62e-03	2.45e-02	0.486	0.43700	0.2120	2.46e-03	1.42e-01

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Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pMANOVA	p.adjustMANOVA	s.dist	s.LPS	s.OVA	p.LPS	p.OVA
EUKARYOTIC TRANSLATION ELONGATION	87	3.59e-25	1.05e-22	0.68000	4.43e-01	0.515000	9.24e-13	9.30e-17
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	8.53e-04	6.42e-03	0.65800	7.89e-02	0.654000	6.50e-01	1.74e-04
MET ACTIVATES RAP1 AND RAC1	11	1.29e-03	8.88e-03	0.61800	-5.67e-01	0.245000	1.12e-03	1.60e-01
COMPLEX I BIOGENESIS	56	1.26e-13	7.33e-12	0.61200	2.95e-01	0.536000	1.33e-04	3.88e-12
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	94	1.66e-21	2.15e-19	0.60300	3.80e-01	0.468000	1.94e-10	4.37e-15
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.27e-03	1.43e-02	0.60100	3.72e-01	0.472000	2.57e-02	4.65e-03
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	3.87e-23	6.45e-21	0.58800	3.24e-01	0.491000	8.10e-09	2.38e-18
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	3.08e-05	4.27e-04	0.58800	-2.22e-01	0.545000	9.34e-02	3.94e-05
INITIAL TRIGGERING OF COMPLEMENT	10	8.52e-03	3.96e-02	0.58200	4.74e-01	0.337000	9.42e-03	6.49e-02
CD28 DEPENDENT VAV1 PATHWAY	10	4.58e-03	2.45e-02	0.57800	-4.09e-01	0.408000	2.51e-02	2.53e-02
EUKARYOTIC TRANSLATION INITIATION	114	6.39e-23	9.31e-21	0.56500	3.06e-01	0.475000	1.75e-08	1.98e-18
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	2.44e-03	1.49e-02	0.55700	3.56e-02	0.556000	8.24e-01	5.24e-04
RESPIRATORY ELECTRON TRANSPORT	102	4.13e-20	4.38e-18	0.55300	2.10e-01	0.512000	2.46e-04	3.92e-19
PINK1 PRKN MEDIATED MITOPHAGY	22	6.14e-05	7.38e-04	0.55300	1.88e-01	0.521000	1.27e-01	2.36e-05
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	12	5.73e-03	2.83e-02	0.55300	3.20e-01	0.451000	5.53e-02	6.81e-03
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	9.83e-12	4.77e-10	0.55100	2.70e-01	0.480000	3.32e-04	1.75e-10
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	4.65e-03	2.45e-02	0.55100	-4.32e-01	0.342000	1.30e-02	4.97e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	4.86e-24	1.13e-21	0.54900	2.16e-01	0.505000	3.17e-05	1.81e-22
COLLAGEN CHAIN TRIMERIZATION	39	9.52e-09	3.36e-07	0.54300	4.23e-01	-0.340000	4.80e-06	2.40e-04
ASPARTATE AND ASPARAGINE METABOLISM	10	1.21e-02	5.23e-02	0.54200	1.36e-02	0.542000	9.40e-01	2.99e-03
SHC MEDIATED CASCADE FGFR3	12	6.60e-03	3.20e-02	0.54100	2.14e-01	0.497000	1.98e-01	2.90e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.52e-06	3.63e-05	0.54000	-2.16e-01	0.495000	4.42e-02	3.90e-06
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.77e-04	1.72e-03	0.53500	-7.03e-03	0.535000	9.57e-01	3.43e-05
SELENOAMINO ACID METABOLISM	107	2.87e-19	2.78e-17	0.53400	3.32e-01	0.418000	3.09e-09	7.55e-14
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	1.13e-02	4.97e-02	0.53400	-1.87e-01	0.500000	3.06e-01	6.19e-03
SCAVENGING BY CLASS A RECEPTORS	13	5.54e-03	2.75e-02	0.53200	4.46e-01	0.291000	5.40e-03	6.91e-02
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	8.63e-03	3.98e-02	0.53200	-5.30e-01	0.048800	2.34e-03	7.79e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	1.83e-02	6.99e-02	0.53000	2.31e-01	0.477000	2.06e-01	8.98e-03
ACTIVATION OF RAC1	13	3.20e-03	1.84e-02	0.53000	-4.96e-01	0.185000	1.95e-03	2.47e-01
TRIGLYCERIDE CATABOLISM	14	2.55e-03	1.54e-02	0.52900	-5.21e-02	0.526000	7.36e-01	6.55e-04
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	15	2.65e-03	1.59e-02	0.52500	1.98e-01	0.487000	1.85e-01	1.10e-03
PI 3K CASCADE FGFR3	12	8.60e-03	3.98e-02	0.52500	1.88e-01	0.491000	2.60e-01	3.26e-03
SHC MEDIATED CASCADE FGFR4	10	1.76e-02	6.84e-02	0.52400	8.37e-02	0.517000	6.47e-01	4.65e-03
FRS MEDIATED FGFR3 SIGNALING	14	3.89e-03	2.15e-02	0.52300	1.51e-01	0.501000	3.27e-01	1.18e-03
COMPLEMENT CASCADE	22	2.31e-04	2.17e-03	0.52100	3.44e-01	0.391000	5.24e-03	1.48e-03
FRS MEDIATED FGFR4 SIGNALING	12	7.96e-03	3.74e-02	0.51900	3.20e-02	0.518000	8.48e-01	1.88e-03
CITRIC ACID CYCLE TCA CYCLE	22	1.67e-04	1.69e-03	0.51900	9.52e-02	0.510000	4.40e-01	3.43e-05
CRMPS IN SEMA3A SIGNALING	16	1.82e-03	1.17e-02	0.51700	-7.66e-02	-0.511000	5.96e-01	3.99e-04
NONSENSE MEDIATED DECAY NMD	109	4.07e-18	3.39e-16	0.51300	3.53e-01	0.372000	2.01e-10	1.88e-11
PI 3K CASCADE FGFR4	10	2.03e-02	7.51e-02	0.51200	5.19e-02	0.510000	7.76e-01	5.26e-03
BLOOD GROUP SYSTEMS BIOSYNTHESIS	13	5.16e-03	2.64e-02	0.51000	-1.25e-01	0.495000	4.35e-01	2.01e-03
G BETA GAMMA SIGNALLING THROUGH CDC42	18	5.93e-04	4.70e-03	0.51000	-2.23e-01	0.459000	1.02e-01	7.54e-04
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	1.18e-03	8.37e-03	0.50900	1.57e-01	0.484000	2.49e-01	3.73e-04
PLATELET SENSITIZATION BY LDL	15	3.41e-03	1.92e-02	0.50500	5.48e-02	0.502000	7.13e-01	7.57e-04
RHOBTB3 ATPASE CYCLE	10	1.87e-02	7.05e-02	0.50500	-1.41e-01	0.485000	4.40e-01	7.95e-03
GLYCOGEN STORAGE DISEASES	12	1.58e-02	6.32e-02	0.49100	1.86e-01	0.455000	2.66e-01	6.37e-03
SEROTONIN RECEPTORS	10	2.08e-02	7.64e-02	0.49100	-3.93e-01	0.294000	3.13e-02	1.07e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.20e-26	4.68e-24	0.49100	1.40e-01	0.471000	1.59e-03	1.72e-26
DARPP 32 EVENTS	23	1.70e-04	1.70e-03	0.48800	-2.01e-01	0.445000	9.54e-02	2.22e-04
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	4.62e-03	2.45e-02	0.48600	4.37e-01	0.212000	2.46e-03	1.42e-01
CROSSLINKING OF COLLAGEN FIBRILS	13	7.69e-03	3.65e-02	0.48400	4.07e-01	-0.260000	1.10e-02	1.04e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	3.30e-03	1.89e-02	0.48100	-8.17e-02	0.474000	5.71e-01	1.02e-03
FATTY ACYL COA BIOSYNTHESIS	32	1.80e-05	2.80e-04	0.48000	5.65e-02	0.477000	5.80e-01	3.02e-06
GLYCOGEN SYNTHESIS	14	8.97e-03	4.10e-02	0.48000	1.01e-01	0.469000	5.15e-01	2.38e-03
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	1.49e-02	6.09e-02	0.47500	4.39e-01	0.182000	6.12e-03	2.56e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	17	3.15e-03	1.83e-02	0.47500	8.47e-03	0.475000	9.52e-01	6.99e-04
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	1.54e-02	6.21e-02	0.47400	1.97e-01	0.431000	2.19e-01	7.08e-03
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	1.68e-02	6.62e-02	0.47300	2.86e-01	0.377000	7.45e-02	1.87e-02
RAS PROCESSING	23	4.75e-04	3.99e-03	0.47200	2.10e-02	0.471000	8.62e-01	9.20e-05
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	3.97e-02	1.22e-01	0.47000	1.05e-01	0.458000	5.64e-01	1.22e-02
JOSEPHIN DOMAIN DUBS	11	3.41e-02	1.10e-01	0.46800	3.01e-01	0.358000	8.42e-02	3.97e-02
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	7.99e-03	3.74e-02	0.46200	-9.23e-04	0.462000	9.95e-01	1.93e-03
MITOPHAGY	29	1.59e-04	1.65e-03	0.45700	1.49e-01	0.433000	1.65e-01	5.53e-05
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	1.68e-03	1.09e-02	0.45700	-4.76e-02	0.455000	7.12e-01	4.30e-04
REGULATION OF EXPRESSION OF SLITS AND ROBOS	160	5.08e-21	5.93e-19	0.45700	2.67e-01	0.371000	5.61e-09	5.84e-16
FGFR2 LIGAND BINDING AND ACTIVATION	12	2.98e-02	9.99e-02	0.45700	2.82e-01	0.359000	9.10e-02	3.12e-02
ENOS ACTIVATION	11	3.05e-02	1.01e-01	0.45400	-6.88e-02	0.449000	6.93e-01	9.93e-03
PROTEIN METHYLATION	17	5.22e-03	2.64e-02	0.45300	3.21e-03	0.453000	9.82e-01	1.21e-03
CRISTAE FORMATION	31	1.06e-04	1.16e-03	0.45200	1.33e-01	0.432000	2.00e-01	3.18e-05
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	1.69e-02	6.65e-02	0.45000	4.42e-01	-0.087600	5.81e-03	5.84e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	62	2.40e-09	9.03e-08	0.44700	3.75e-01	-0.244000	3.27e-07	8.92e-04
TRANSLATION	286	3.64e-35	4.25e-32	0.44600	2.32e-01	0.381000	1.72e-11	1.66e-28
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	3.35e-02	1.09e-01	0.44400	-1.30e-01	0.425000	4.56e-01	1.47e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	9.54e-03	4.31e-02	0.44200	-1.90e-01	0.399000	2.04e-01	7.41e-03
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	19	5.03e-03	2.62e-02	0.44200	1.79e-01	0.404000	1.77e-01	2.32e-03
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	5.05e-02	1.46e-01	0.44000	-3.10e-01	-0.312000	7.48e-02	7.31e-02
GLYCOGEN METABOLISM	25	1.06e-03	7.76e-03	0.43900	2.03e-01	0.389000	7.88e-02	7.52e-04
MITOCHONDRIAL TRANSLATION	93	1.79e-11	8.04e-10	0.43400	2.20e-01	0.375000	2.46e-04	4.31e-10
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	3.31e-03	1.89e-02	0.43400	4.33e-01	-0.025800	8.02e-04	8.42e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	5.21e-02	1.49e-01	0.43300	-1.51e-01	0.406000	4.08e-01	2.62e-02
CELLULAR RESPONSE TO STARVATION	145	7.89e-17	5.75e-15	0.42800	2.47e-01	0.349000	2.76e-07	4.31e-13
CTLA4 INHIBITORY SIGNALING	19	4.45e-03	2.39e-02	0.42700	-1.21e-01	0.410000	3.63e-01	1.99e-03
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	3.60e-02	1.14e-01	0.42600	-3.83e-02	0.425000	8.18e-01	1.09e-02
SIGNAL AMPLIFICATION	30	2.40e-04	2.22e-03	0.42600	-5.22e-02	0.423000	6.21e-01	6.11e-05
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	4.30e-02	1.28e-01	0.42400	9.64e-02	0.413000	5.63e-01	1.33e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	17	1.36e-02	5.80e-02	0.41600	9.79e-02	0.405000	4.85e-01	3.87e-03
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	31	3.70e-04	3.19e-03	0.41600	6.68e-02	0.411000	5.20e-01	7.54e-05
METABOLISM OF AMINO ACIDS AND DERIVATIVES	307	6.70e-33	3.91e-30	0.41500	1.85e-01	0.371000	2.49e-08	5.44e-29
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	3.33e-03	1.89e-02	0.41300	-2.32e-02	0.413000	8.51e-01	8.03e-04
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	4.48e-07	1.27e-05	0.41200	8.92e-02	0.402000	2.36e-01	9.03e-08
BRANCHED CHAIN AMINO ACID CATABOLISM	21	4.68e-03	2.46e-02	0.41200	2.37e-03	0.412000	9.85e-01	1.08e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	1.36e-05	2.23e-04	0.41100	1.35e-01	0.389000	1.14e-01	5.06e-06
ER QUALITY CONTROL COMPARTMENT ERQC	21	4.63e-03	2.45e-02	0.40900	-4.10e-02	0.407000	7.45e-01	1.23e-03
PROCESSING AND ACTIVATION OF SUMO	10	6.77e-02	1.74e-01	0.40900	-2.91e-01	0.287000	1.11e-01	1.16e-01
GAP JUNCTION DEGRADATION	11	6.95e-02	1.77e-01	0.40900	1.13e-01	0.393000	5.16e-01	2.41e-02
METABOLISM OF POLYAMINES	57	9.57e-07	2.37e-05	0.40800	7.73e-02	0.400000	3.13e-01	1.74e-07
CALNEXIN CALRETICULIN CYCLE	26	1.62e-03	1.07e-02	0.40600	1.50e-02	0.406000	8.94e-01	3.40e-04
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	3.06e-06	6.61e-05	0.40300	-5.91e-02	0.399000	4.65e-01	8.51e-07
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	7.91e-02	1.93e-01	0.40200	1.64e-01	0.367000	3.47e-01	3.51e-02
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	2.50e-02	8.66e-02	0.40100	1.51e-01	0.371000	2.95e-01	1.01e-02
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	3.02e-03	1.77e-02	0.39900	-1.97e-02	0.399000	8.68e-01	7.18e-04
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	6.66e-06	1.21e-04	0.39700	1.53e-01	0.366000	5.39e-02	4.05e-06
GLUTATHIONE CONJUGATION	29	1.26e-03	8.70e-03	0.39600	6.64e-02	0.390000	5.36e-01	2.77e-04
PYRUVATE METABOLISM	27	1.24e-03	8.65e-03	0.39500	-1.85e-01	0.348000	9.55e-02	1.73e-03
GLUCONEOGENESIS	27	2.37e-03	1.48e-02	0.39400	1.23e-01	0.374000	2.69e-01	7.63e-04
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	49	6.04e-06	1.15e-04	0.39400	3.57e-01	-0.165000	1.51e-05	4.57e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	24	4.37e-03	2.37e-02	0.39300	8.03e-02	0.385000	4.96e-01	1.09e-03
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	2.73e-04	2.47e-03	0.39300	-2.89e-02	0.392000	7.67e-01	6.07e-05
PEXOPHAGY	11	9.30e-02	2.15e-01	0.39200	3.15e-01	0.233000	7.03e-02	1.81e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	2.44e-02	8.55e-02	0.39100	-3.90e-01	0.024800	6.91e-03	8.64e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	6.17e-06	1.16e-04	0.39000	7.78e-02	0.382000	3.23e-01	1.21e-06
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	4.04e-02	1.23e-01	0.38900	2.09e-01	0.329000	1.61e-01	2.76e-02
METHYLATION	11	9.09e-02	2.12e-01	0.38900	1.25e-01	0.368000	4.73e-01	3.45e-02
TRP CHANNELS	19	1.37e-02	5.83e-02	0.38900	-2.18e-02	-0.388000	8.69e-01	3.41e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	1.20e-01	2.58e-01	0.38900	-2.39e-01	-0.306000	1.90e-01	9.37e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	9.99e-06	1.66e-04	0.38800	1.24e-01	0.368000	1.18e-01	3.58e-06
GLUTAMATE AND GLUTAMINE METABOLISM	13	6.42e-02	1.69e-01	0.38800	2.98e-01	0.248000	6.24e-02	1.22e-01
BETA CATENIN PHOSPHORYLATION CASCADE	16	2.13e-02	7.76e-02	0.38800	-2.05e-01	0.329000	1.56e-01	2.25e-02
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	2.12e-02	7.76e-02	0.38600	2.71e-02	-0.385000	8.47e-01	5.96e-03
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	2.80e-02	9.64e-02	0.38500	-2.19e-01	0.317000	1.42e-01	3.34e-02
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	5.32e-02	1.50e-01	0.38500	3.83e-01	-0.037800	1.69e-02	8.13e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	7.64e-02	1.89e-01	0.38400	-1.62e-01	0.348000	3.51e-01	4.58e-02
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	6.65e-02	1.73e-01	0.38300	1.65e-01	0.345000	3.03e-01	3.11e-02
HEDGEHOG LIGAND BIOGENESIS	61	2.85e-06	6.27e-05	0.38200	1.37e-01	0.357000	6.48e-02	1.43e-06
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	7.55e-02	1.88e-01	0.38200	2.42e-01	-0.295000	1.64e-01	8.99e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	4.97e-04	4.08e-03	0.38200	2.74e-02	0.381000	7.79e-01	9.59e-05
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	13	5.94e-02	1.61e-01	0.38200	2.82e-02	0.381000	8.60e-01	1.75e-02
CS DS DEGRADATION	14	5.77e-02	1.58e-01	0.38100	2.72e-01	0.267000	7.81e-02	8.34e-02
CHAPERONE MEDIATED AUTOPHAGY	20	1.70e-02	6.66e-02	0.38100	2.47e-01	0.291000	5.64e-02	2.44e-02
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	5.15e-03	2.64e-02	0.38100	-1.44e-01	0.353000	2.33e-01	3.40e-03
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	8.18e-02	1.96e-01	0.38000	-1.28e-01	0.358000	4.61e-01	3.98e-02
RHO GTPASES ACTIVATE WASPS AND WAVES	36	2.53e-04	2.30e-03	0.38000	-1.89e-01	0.330000	5.00e-02	6.22e-04
ANCHORING FIBRIL FORMATION	13	4.94e-02	1.44e-01	0.38000	2.21e-01	-0.309000	1.67e-01	5.41e-02
INSULIN RECEPTOR RECYCLING	20	1.14e-02	5.02e-02	0.37900	-1.01e-01	0.365000	4.33e-01	4.73e-03
DEGRADATION OF GLI1 BY THE PROTEASOME	57	7.46e-06	1.28e-04	0.37800	1.07e-01	0.363000	1.64e-01	2.13e-06
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	6.56e-02	1.71e-01	0.37800	-1.74e-01	0.335000	2.97e-01	4.44e-02
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	10	1.33e-01	2.78e-01	0.37700	-3.34e-01	-0.174000	6.74e-02	3.40e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	11	1.12e-01	2.46e-01	0.37600	3.01e-01	0.226000	8.35e-02	1.95e-01
PYRIMIDINE SALVAGE	10	1.38e-01	2.83e-01	0.37600	-2.86e-01	-0.244000	1.17e-01	1.82e-01
INFLUENZA INFECTION	145	4.85e-13	2.69e-11	0.37400	2.15e-01	0.306000	7.61e-06	2.16e-10
E2F MEDIATED REGULATION OF DNA REPLICATION	19	1.44e-02	6.01e-02	0.37300	-3.01e-01	0.219000	2.29e-02	9.78e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	3.54e-06	7.38e-05	0.37000	8.98e-02	0.359000	2.18e-01	8.22e-07
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	9.29e-02	2.15e-01	0.36900	1.01e-01	0.355000	5.45e-01	3.30e-02
SIGNALING BY FGFR4 IN DISEASE	10	1.13e-01	2.48e-01	0.36900	-1.92e-01	0.315000	2.93e-01	8.45e-02
CYTOSOLIC TRNA AMINOACYLATION	24	1.02e-02	4.58e-02	0.36800	3.03e-01	0.210000	1.03e-02	7.53e-02
COLLAGEN FORMATION	77	6.48e-08	2.16e-06	0.36800	3.26e-01	-0.170000	7.50e-07	9.79e-03
PENTOSE PHOSPHATE PATHWAY	13	6.28e-02	1.67e-01	0.36700	-1.44e-01	0.338000	3.69e-01	3.51e-02
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	1.44e-02	6.01e-02	0.36600	3.43e-01	0.128000	5.36e-03	2.98e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	1.00e-02	4.50e-02	0.36500	4.67e-03	0.365000	9.69e-01	2.45e-03
ERYTHROPOIETIN ACTIVATES RAS	13	7.51e-02	1.87e-01	0.36500	1.42e-02	0.364000	9.30e-01	2.29e-02
STABILIZATION OF P53	54	3.31e-05	4.48e-04	0.36400	1.08e-01	0.347000	1.70e-01	1.01e-05
ACTIVATION OF SMO	16	3.38e-02	1.09e-01	0.36400	3.05e-01	-0.198000	3.48e-02	1.70e-01
GLUTATHIONE SYNTHESIS AND RECYCLING	11	1.26e-01	2.65e-01	0.36300	1.49e-01	0.332000	3.94e-01	5.69e-02
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	3.42e-02	1.10e-01	0.36200	-3.33e-01	-0.141000	1.44e-02	2.99e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	12	9.90e-02	2.26e-01	0.36200	5.66e-02	0.357000	7.34e-01	3.22e-02
RHO GTPASES ACTIVATE ROCKS	19	2.96e-02	9.96e-02	0.36200	3.17e-01	0.174000	1.68e-02	1.89e-01
SMOOTH MUSCLE CONTRACTION	33	2.39e-03	1.48e-02	0.36100	2.91e-01	0.213000	3.81e-03	3.40e-02
MITOCHONDRIAL PROTEIN IMPORT	63	7.34e-06	1.28e-04	0.36000	1.00e-01	0.346000	1.68e-01	2.06e-06
SYNTHESIS OF BILE ACIDS AND BILE SALTS	21	2.26e-02	8.01e-02	0.35900	2.47e-01	0.260000	4.99e-02	3.90e-02
TRIGLYCERIDE METABOLISM	22	1.32e-02	5.68e-02	0.35900	-3.82e-02	0.357000	7.56e-01	3.77e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	7.95e-02	1.93e-01	0.35800	-1.98e-02	0.358000	9.02e-01	2.55e-02
FERTILIZATION	12	8.88e-02	2.07e-01	0.35700	3.23e-01	-0.152000	5.31e-02	3.62e-01
DEGRADATION OF AXIN	53	6.10e-05	7.38e-04	0.35600	9.68e-02	0.342000	2.23e-01	1.65e-05
IRON UPTAKE AND TRANSPORT	51	4.33e-05	5.55e-04	0.35500	-1.05e-01	0.339000	1.95e-01	2.79e-05
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	4.30e-07	1.25e-05	0.35400	9.76e-03	0.354000	8.82e-01	6.31e-08
SUPPRESSION OF PHAGOSOMAL MATURATION	12	1.08e-01	2.41e-01	0.35400	4.51e-02	0.351000	7.87e-01	3.54e-02
FRS MEDIATED FGFR2 SIGNALING	18	3.56e-02	1.13e-01	0.35400	3.91e-02	0.351000	7.74e-01	9.86e-03
RRNA PROCESSING	194	2.61e-15	1.60e-13	0.35300	2.37e-01	0.262000	1.38e-08	3.25e-10
SIGNALING BY ROBO RECEPTORS	205	3.49e-16	2.40e-14	0.35200	1.78e-01	0.304000	1.17e-05	6.74e-14
NOTCH HLH TRANSCRIPTION PATHWAY	28	4.03e-03	2.22e-02	0.35000	2.27e-01	-0.267000	3.78e-02	1.47e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	11	1.15e-01	2.51e-01	0.34900	-2.48e-01	0.246000	1.54e-01	1.58e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	4.35e-02	1.29e-01	0.34900	1.41e-01	0.319000	3.00e-01	1.90e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	59	3.05e-05	4.27e-04	0.34800	8.59e-02	0.338000	2.54e-01	7.34e-06
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	9.16e-02	2.13e-01	0.34800	1.84e-01	0.295000	2.33e-01	5.61e-02
AGGREPHAGY	35	1.94e-03	1.24e-02	0.34700	3.45e-01	0.042100	4.17e-04	6.67e-01
COLLAGEN DEGRADATION	49	8.75e-05	9.91e-04	0.34700	3.15e-01	-0.146000	1.39e-04	7.64e-02
KILLING MECHANISMS	10	1.53e-01	3.08e-01	0.34600	1.14e-01	-0.327000	5.34e-01	7.38e-02
CGMP EFFECTS	15	7.95e-02	1.93e-01	0.34600	-2.96e-01	-0.179000	4.74e-02	2.31e-01
RECEPTOR MEDIATED MITOPHAGY	11	1.42e-01	2.90e-01	0.34500	2.97e-02	0.344000	8.64e-01	4.83e-02
PROLONGED ERK ACTIVATION EVENTS	14	6.82e-02	1.75e-01	0.34500	-2.53e-01	0.234000	1.01e-01	1.29e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	1.97e-02	7.36e-02	0.34500	-3.26e-01	0.112000	9.64e-03	3.73e-01
PROTEIN UBIQUITINATION	69	2.39e-06	5.36e-05	0.34500	-1.33e-01	0.319000	5.70e-02	4.77e-06
RESPONSE OF MTB TO PHAGOCYTOSIS	21	2.30e-02	8.10e-02	0.34300	-3.63e-02	0.341000	7.74e-01	6.83e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	66	1.77e-05	2.79e-04	0.34100	1.44e-01	0.309000	4.29e-02	1.38e-05
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	8.67e-07	2.20e-05	0.34100	5.68e-02	0.336000	3.74e-01	1.46e-07
P75NTR SIGNALS VIA NF KB	16	6.74e-02	1.74e-01	0.34100	3.29e-01	0.089300	2.28e-02	5.36e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	7.47e-02	1.87e-01	0.34000	2.87e-01	-0.182000	6.28e-02	2.38e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	28	7.36e-03	3.53e-02	0.33900	-3.47e-02	0.337000	7.50e-01	2.01e-03
SEMA4D IN SEMAPHORIN SIGNALING	24	1.65e-02	6.54e-02	0.33900	3.38e-01	0.025600	4.17e-03	8.28e-01
RHOBTB2 GTPASE CYCLE	23	2.35e-02	8.26e-02	0.33900	1.53e-01	0.302000	2.03e-01	1.22e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	5.29e-05	6.49e-04	0.33700	5.22e-02	0.333000	4.88e-01	9.83e-06
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	4.15e-02	1.25e-01	0.33600	-9.78e-02	0.322000	4.72e-01	1.81e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	1.19e-01	2.57e-01	0.33600	3.24e-01	0.089000	4.32e-02	5.79e-01
RHO GTPASES ACTIVATE CIT	18	5.83e-02	1.59e-01	0.33600	2.51e-01	0.223000	6.57e-02	1.01e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	11	1.63e-01	3.25e-01	0.33600	7.11e-02	0.328000	6.83e-01	5.97e-02
DERMATAN SULFATE BIOSYNTHESIS	11	1.75e-01	3.44e-01	0.33500	1.93e-01	0.274000	2.67e-01	1.15e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	5.12e-02	1.47e-01	0.33500	3.24e-01	-0.086900	2.09e-02	5.35e-01
ANTIGEN PROCESSING CROSS PRESENTATION	93	2.99e-07	8.94e-06	0.33400	9.31e-02	0.321000	1.21e-01	8.68e-08
CELLULAR RESPONSE TO HYPOXIA	71	9.98e-06	1.66e-04	0.33400	7.94e-02	0.324000	2.48e-01	2.28e-06
REGULATION OF PTEN STABILITY AND ACTIVITY	66	2.22e-05	3.32e-04	0.33300	6.85e-02	0.326000	3.36e-01	4.56e-06
TIGHT JUNCTION INTERACTIONS	18	4.23e-02	1.27e-01	0.33300	-3.05e-01	0.135000	2.53e-02	3.22e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	21	3.37e-02	1.09e-01	0.33300	7.86e-02	0.323000	5.33e-01	1.03e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	36	3.02e-03	1.77e-02	0.33200	-7.08e-02	-0.325000	4.62e-01	7.54e-04
MET ACTIVATES PTK2 SIGNALING	29	6.19e-03	3.02e-02	0.33200	2.93e-01	-0.156000	6.37e-03	1.45e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	1.16e-02	5.07e-02	0.33200	-8.46e-02	0.321000	4.55e-01	4.63e-03
SYNDECAN INTERACTIONS	26	1.82e-02	6.99e-02	0.33200	2.50e-01	0.218000	2.74e-02	5.46e-02
FCERI MEDIATED NF KB ACTIVATION	76	5.14e-06	1.03e-04	0.33100	5.68e-02	0.326000	3.92e-01	9.18e-07
DEGRADATION OF DVL	55	1.94e-04	1.86e-03	0.33000	1.24e-01	0.305000	1.11e-01	8.98e-05
PI 3K CASCADE FGFR2	16	7.77e-02	1.91e-01	0.32900	5.24e-02	0.325000	7.17e-01	2.44e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS	12	1.27e-01	2.69e-01	0.32900	-2.97e-01	0.141000	7.49e-02	3.97e-01
INTERLEUKIN 37 SIGNALING	19	5.50e-02	1.54e-01	0.32800	2.89e-01	0.155000	2.92e-02	2.42e-01
INTERACTION BETWEEN L1 AND ANKYRINS	29	8.52e-03	3.96e-02	0.32800	3.63e-02	-0.326000	7.35e-01	2.38e-03
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	1.63e-01	3.24e-01	0.32700	2.78e-01	0.174000	9.60e-02	2.98e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	1.98e-02	7.36e-02	0.32700	1.71e-01	0.279000	1.31e-01	1.40e-02
P75NTR RECRUITS SIGNALLING COMPLEXES	13	1.34e-01	2.78e-01	0.32700	3.12e-01	0.097700	5.14e-02	5.42e-01
REGULATION OF IFNG SIGNALING	13	1.10e-01	2.43e-01	0.32700	-2.90e-01	0.150000	6.98e-02	3.49e-01
ELASTIC FIBRE FORMATION	36	4.20e-03	2.30e-02	0.32600	3.00e-01	0.127000	1.83e-03	1.86e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	7.31e-02	1.84e-01	0.32500	-3.14e-01	-0.083500	2.48e-02	5.51e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	23	2.96e-02	9.96e-02	0.32500	9.46e-02	0.311000	4.32e-01	9.81e-03
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	3.35e-02	1.09e-01	0.32500	-2.32e-01	0.228000	7.29e-02	7.81e-02
INSULIN PROCESSING	24	1.99e-02	7.38e-02	0.32300	-3.09e-01	0.095700	8.89e-03	4.17e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	4.06e-02	1.24e-01	0.32300	6.33e-02	0.316000	6.16e-01	1.21e-02
NCAM1 INTERACTIONS	39	1.46e-03	9.86e-03	0.32300	2.10e-01	-0.245000	2.32e-02	8.14e-03
LDL CLEARANCE	16	8.61e-02	2.03e-01	0.32200	4.74e-02	0.319000	7.43e-01	2.73e-02
PLATELET ADHESION TO EXPOSED COLLAGEN	12	1.70e-01	3.36e-01	0.32200	1.45e-01	0.288000	3.85e-01	8.45e-02
RAB GERANYLGERANYLATION	57	7.48e-05	8.72e-04	0.32200	-2.32e-01	0.224000	2.48e-03	3.52e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	1.89e-01	3.63e-01	0.32100	-2.37e-01	0.217000	1.94e-01	2.35e-01
PHASE II CONJUGATION OF COMPOUNDS	60	9.41e-05	1.05e-03	0.32100	1.07e-02	0.321000	8.86e-01	1.68e-05
PKMTS METHYLATE HISTONE LYSINES	48	5.44e-04	4.43e-03	0.32100	2.38e-02	-0.320000	7.76e-01	1.24e-04
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	1.45e-02	6.01e-02	0.32000	-1.36e-01	0.290000	2.29e-01	1.05e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	2.96e-02	9.96e-02	0.32000	-8.71e-02	0.308000	4.80e-01	1.23e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	8.62e-02	2.03e-01	0.32000	-2.77e-01	0.159000	6.29e-02	2.85e-01
ECM PROTEOGLYCANS	64	3.95e-05	5.14e-04	0.32000	3.10e-01	-0.077000	1.78e-05	2.87e-01
BUDDING AND MATURATION OF HIV VIRION	27	1.78e-02	6.86e-02	0.31800	5.16e-02	0.314000	6.43e-01	4.71e-03
ROS AND RNS PRODUCTION IN PHAGOCYTES	28	1.53e-02	6.19e-02	0.31800	4.86e-02	0.315000	6.56e-01	3.96e-03
ABC TRANSPORTER DISORDERS	69	4.56e-05	5.71e-04	0.31800	1.09e-01	0.298000	1.17e-01	1.82e-05
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	2.26e-01	3.99e-01	0.31700	-3.15e-01	-0.041100	8.50e-02	8.22e-01
TIE2 SIGNALING	17	7.85e-02	1.91e-01	0.31700	1.78e-02	0.316000	8.99e-01	2.41e-02
G PROTEIN ACTIVATION	22	3.50e-02	1.12e-01	0.31600	-2.61e-02	0.315000	8.32e-01	1.05e-02
MET RECEPTOR RECYCLING	10	2.05e-01	3.82e-01	0.31600	-1.33e-01	0.287000	4.67e-01	1.16e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	23	3.60e-02	1.14e-01	0.31600	8.63e-02	0.304000	4.74e-01	1.17e-02
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	5.35e-02	1.50e-01	0.31500	-7.03e-02	0.307000	5.96e-01	2.04e-02
NUCLEOBASE BIOSYNTHESIS	15	1.01e-01	2.29e-01	0.31500	-4.62e-02	0.312000	7.57e-01	3.66e-02
PROTEIN LOCALIZATION	156	8.85e-11	3.82e-09	0.31500	-5.27e-03	0.315000	9.10e-01	1.21e-11
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	3.85e-02	1.19e-01	0.31500	1.22e-01	0.290000	3.11e-01	1.61e-02
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	2.34e-03	1.47e-02	0.31400	9.26e-03	0.314000	9.18e-01	5.06e-04
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	1.24e-02	5.38e-02	0.31400	3.18e-02	0.312000	7.63e-01	3.07e-03
INFLAMMASOMES	19	5.73e-02	1.57e-01	0.31400	-3.39e-02	0.312000	7.98e-01	1.86e-02
SULFUR AMINO ACID METABOLISM	22	4.45e-02	1.32e-01	0.31300	1.03e-01	0.296000	4.03e-01	1.62e-02
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	2.32e-01	4.08e-01	0.31300	3.15e-02	0.312000	8.63e-01	8.78e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	7.27e-02	1.84e-01	0.31300	1.63e-01	0.267000	2.18e-01	4.43e-02
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	7.89e-05	9.11e-04	0.31200	3.12e-01	0.010100	1.40e-05	8.88e-01
SIGNALING BY BMP	24	2.48e-02	8.61e-02	0.31000	-1.73e-01	0.258000	1.43e-01	2.89e-02
SYNAPTIC ADHESION LIKE MOLECULES	21	4.91e-02	1.44e-01	0.31000	-1.79e-02	-0.309000	8.87e-01	1.41e-02
PURINE CATABOLISM	16	1.15e-01	2.51e-01	0.31000	1.71e-01	0.258000	2.37e-01	7.36e-02
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	1.19e-02	5.17e-02	0.30900	-1.70e-01	0.258000	1.14e-01	1.61e-02
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	1.35e-01	2.80e-01	0.30900	7.30e-03	0.309000	9.62e-01	4.56e-02
FATTY ACID METABOLISM	146	1.24e-09	4.97e-08	0.30900	2.95e-02	0.307000	5.39e-01	1.52e-10
IRAK4 DEFICIENCY TLR2 4	12	1.83e-01	3.55e-01	0.30800	2.81e-02	0.307000	8.66e-01	6.54e-02
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	1.41e-01	2.88e-01	0.30800	-1.33e-01	0.278000	4.07e-01	8.27e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	9.99e-03	4.50e-02	0.30800	4.94e-02	0.304000	6.24e-01	2.51e-03
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	1.22e-01	2.59e-01	0.30800	-2.76e-01	0.136000	7.40e-02	3.77e-01
MRNA SPLICING	188	1.22e-11	5.68e-10	0.30700	2.80e-01	0.128000	3.85e-11	2.58e-03
G PROTEIN BETA GAMMA SIGNALLING	30	1.07e-02	4.77e-02	0.30700	-1.73e-01	0.254000	1.01e-01	1.61e-02
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	11	2.33e-01	4.09e-01	0.30600	2.53e-01	0.173000	1.46e-01	3.22e-01
SIGNALING BY THE B CELL RECEPTOR BCR	103	5.15e-07	1.43e-05	0.30600	-5.37e-03	0.306000	9.25e-01	8.27e-08
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	32	1.38e-02	5.84e-02	0.30500	2.85e-01	0.109000	5.26e-03	2.84e-01
GPVI MEDIATED ACTIVATION CASCADE	31	1.45e-02	6.01e-02	0.30500	5.75e-02	0.300000	5.80e-01	3.87e-03
SIGNALING BY FGFR4	31	1.39e-02	5.84e-02	0.30500	3.26e-02	0.303000	7.53e-01	3.47e-03
BIOLOGICAL OXIDATIONS	123	8.33e-08	2.70e-06	0.30400	9.72e-02	0.288000	6.28e-02	3.51e-08
NEGATIVE REGULATION OF FGFR4 SIGNALING	21	5.56e-02	1.54e-01	0.30400	2.09e-02	0.303000	8.68e-01	1.62e-02
REDUCTION OF CYTOSOLIC CA LEVELS	11	2.26e-01	3.99e-01	0.30300	-2.99e-01	-0.049700	8.59e-02	7.75e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	21	6.62e-02	1.72e-01	0.30300	1.65e-01	0.254000	1.89e-01	4.42e-02
GAP JUNCTION ASSEMBLY	21	6.76e-02	1.74e-01	0.30200	2.33e-01	0.193000	6.50e-02	1.25e-01
FRS MEDIATED FGFR1 SIGNALING	17	1.01e-01	2.28e-01	0.30200	3.64e-02	0.300000	7.95e-01	3.24e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	1.13e-01	2.48e-01	0.30200	-1.46e-01	0.264000	3.28e-01	7.64e-02
RAP1 SIGNALLING	15	1.12e-01	2.46e-01	0.30200	-2.41e-01	0.181000	1.05e-01	2.25e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	2.25e-01	3.99e-01	0.30200	1.99e-02	0.301000	9.09e-01	8.39e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	1.92e-01	3.66e-01	0.30100	2.07e-01	0.218000	1.96e-01	1.74e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	2.15e-01	3.92e-01	0.30100	1.52e-01	0.259000	3.60e-01	1.20e-01
RAF ACTIVATION	34	7.98e-03	3.74e-02	0.30000	-1.09e-01	0.280000	2.74e-01	4.71e-03
ANTIMICROBIAL PEPTIDES	13	1.92e-01	3.66e-01	0.30000	1.75e-01	0.244000	2.76e-01	1.27e-01
ORC1 REMOVAL FROM CHROMATIN	67	1.16e-04	1.26e-03	0.30000	7.52e-04	0.300000	9.92e-01	2.17e-05
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	1.77e-02	6.84e-02	0.30000	-6.68e-02	0.292000	5.33e-01	6.49e-03
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	64	1.67e-04	1.69e-03	0.30000	-1.91e-02	0.299000	7.92e-01	3.55e-05
MRNA SPLICING MINOR PATHWAY	52	1.49e-03	9.98e-03	0.29900	2.16e-01	0.207000	7.12e-03	9.77e-03
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	69	1.26e-04	1.33e-03	0.29900	6.07e-02	0.292000	3.83e-01	2.69e-05
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	2.79e-01	4.56e-01	0.29800	-9.87e-02	-0.281000	5.89e-01	1.24e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	12	1.83e-01	3.55e-01	0.29700	-2.54e-01	0.154000	1.27e-01	3.55e-01
G1 S DNA DAMAGE CHECKPOINTS	65	2.48e-04	2.27e-03	0.29700	8.54e-02	0.285000	2.34e-01	7.16e-05
GABA RECEPTOR ACTIVATION	52	6.21e-04	4.86e-03	0.29700	-1.96e-01	0.224000	1.46e-02	5.28e-03
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	50	1.00e-03	7.39e-03	0.29700	-9.93e-02	0.280000	2.24e-01	6.28e-04
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	8.48e-02	2.01e-01	0.29600	7.98e-02	-0.286000	5.58e-01	3.60e-02
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	32	1.48e-02	6.06e-02	0.29600	7.49e-03	0.296000	9.42e-01	3.72e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	2.15e-02	7.82e-02	0.29600	-6.47e-02	-0.289000	5.40e-01	6.18e-03
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	2.87e-01	4.67e-01	0.29600	-2.68e-01	-0.126000	1.43e-01	4.90e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	69	1.49e-04	1.56e-03	0.29600	5.98e-02	0.290000	3.90e-01	3.20e-05
CLEC7A DECTIN 1 SIGNALING	94	5.46e-06	1.06e-04	0.29600	3.42e-02	0.294000	5.67e-01	8.76e-07
P75NTR REGULATES AXONOGENESIS	10	2.47e-01	4.22e-01	0.29600	-2.51e-01	0.156000	1.69e-01	3.93e-01
LYSOSOME VESICLE BIOGENESIS	33	1.46e-02	6.05e-02	0.29500	5.03e-02	0.291000	6.17e-01	3.84e-03
SARS COV 2 INFECTION	65	1.76e-04	1.72e-03	0.29500	-4.00e-02	0.292000	5.77e-01	4.67e-05
INTERFERON ALPHA BETA SIGNALING	52	9.58e-04	7.16e-03	0.29500	-2.90e-01	0.053100	3.01e-04	5.08e-01
AQUAPORIN MEDIATED TRANSPORT	40	5.24e-03	2.64e-02	0.29400	-1.83e-02	0.294000	8.41e-01	1.31e-03
DISEASES OF DNA REPAIR	11	2.19e-01	3.93e-01	0.29400	2.54e-01	-0.149000	1.45e-01	3.92e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	60	7.21e-04	5.46e-03	0.29300	1.75e-01	0.235000	1.89e-02	1.64e-03
LGI ADAM INTERACTIONS	14	1.44e-01	2.93e-01	0.29300	1.92e-01	-0.222000	2.15e-01	1.51e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	2.90e-02	9.86e-02	0.29300	1.33e-01	0.261000	2.17e-01	1.48e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	2.32e-05	3.38e-04	0.29300	2.74e-02	0.292000	6.65e-01	3.86e-06
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	37	7.68e-03	3.65e-02	0.29300	-4.76e-02	0.289000	6.17e-01	2.38e-03
CELLULAR RESPONSE TO CHEMICAL STRESS	149	1.28e-08	4.38e-07	0.29200	1.03e-01	0.274000	2.95e-02	8.42e-09
TNFR2 NON CANONICAL NF KB PATHWAY	79	6.85e-05	8.07e-04	0.29200	1.16e-01	0.268000	7.57e-02	3.85e-05
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	1.48e-02	6.06e-02	0.29200	-6.40e-02	0.285000	5.31e-01	5.35e-03
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	8.89e-02	2.07e-01	0.29100	-2.66e-01	-0.118000	3.93e-02	3.62e-01
C TYPE LECTIN RECEPTORS CLRS	111	8.61e-07	2.20e-05	0.29100	1.84e-02	0.290000	7.38e-01	1.26e-07
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	5.93e-04	4.70e-03	0.29000	-1.76e-01	0.231000	2.42e-02	3.05e-03
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	2.05e-01	3.82e-01	0.28900	-2.66e-01	0.113000	1.11e-01	4.97e-01
REPRESSION OF WNT TARGET GENES	14	1.93e-01	3.66e-01	0.28900	2.39e-01	0.162000	1.21e-01	2.95e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	2.13e-02	7.76e-02	0.28900	1.89e-01	0.218000	5.98e-02	3.04e-02
REGULATION OF RAS BY GAPS	66	3.31e-04	2.92e-03	0.28800	5.86e-02	0.282000	4.11e-01	7.32e-05
CD28 CO STIMULATION	29	2.19e-02	7.92e-02	0.28800	-2.53e-01	0.137000	1.85e-02	2.01e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	2.87e-02	9.81e-02	0.28800	-1.30e-01	0.256000	2.41e-01	2.11e-02
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	2.59e-01	4.35e-01	0.28700	1.80e-02	0.286000	9.18e-01	1.00e-01
PYROPTOSIS	20	7.97e-02	1.93e-01	0.28700	-4.60e-02	0.283000	7.22e-01	2.85e-02
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	6.24e-02	1.66e-01	0.28700	-2.18e-01	0.186000	8.33e-02	1.41e-01
SHC1 EVENTS IN EGFR SIGNALING	11	2.34e-01	4.09e-01	0.28600	-1.82e-01	0.221000	2.97e-01	2.04e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	2.09e-01	3.85e-01	0.28600	-2.52e-01	0.136000	1.31e-01	4.15e-01
SIGNALING BY HIPPO	20	7.26e-02	1.84e-01	0.28500	-2.15e-01	0.188000	9.64e-02	1.45e-01
SIGNALING BY FGFR3	34	1.76e-02	6.84e-02	0.28500	6.02e-02	0.279000	5.44e-01	4.93e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	1.42e-01	2.90e-01	0.28500	-1.43e-01	-0.246000	3.08e-01	7.88e-02
PRE NOTCH PROCESSING IN GOLGI	17	1.45e-01	2.94e-01	0.28500	2.20e-01	0.181000	1.17e-01	1.97e-01
RHO GTPASES ACTIVATE KTN1	11	2.74e-01	4.52e-01	0.28400	7.42e-02	0.275000	6.70e-01	1.15e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	67	1.74e-04	1.72e-03	0.28400	-1.61e-01	0.234000	2.28e-02	9.17e-04
BILE ACID AND BILE SALT METABOLISM	24	6.66e-02	1.73e-01	0.28400	1.87e-01	0.214000	1.13e-01	7.00e-02
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	13	2.02e-01	3.79e-01	0.28400	-3.05e-02	0.282000	8.49e-01	7.82e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	23	5.17e-02	1.49e-01	0.28300	-1.61e-01	0.233000	1.82e-01	5.28e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	23	5.48e-02	1.53e-01	0.28300	-1.04e-01	0.263000	3.89e-01	2.89e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT	93	2.03e-05	3.12e-04	0.28300	6.54e-02	0.275000	2.76e-01	4.57e-06
SIGNALING BY RETINOIC ACID	32	1.85e-02	7.04e-02	0.28200	-8.47e-02	0.269000	4.07e-01	8.40e-03
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	11	2.95e-01	4.74e-01	0.28100	2.14e-01	0.183000	2.20e-01	2.93e-01
HYALURONAN UPTAKE AND DEGRADATION	11	2.64e-01	4.39e-01	0.28100	-4.02e-02	0.278000	8.17e-01	1.11e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	107	5.44e-06	1.06e-04	0.28000	8.18e-02	0.268000	1.44e-01	1.65e-06
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	3.31e-01	5.04e-01	0.28000	-1.42e-01	-0.241000	4.36e-01	1.88e-01
SHC MEDIATED CASCADE FGFR1	15	1.83e-01	3.55e-01	0.27900	7.16e-02	0.270000	6.31e-01	7.06e-02
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	2.43e-01	4.18e-01	0.27900	2.07e-01	0.187000	1.97e-01	2.44e-01
KINESINS	47	3.12e-03	1.82e-02	0.27800	1.21e-01	-0.251000	1.51e-01	2.96e-03
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	2.21e-02	7.94e-02	0.27600	8.07e-02	-0.264000	4.29e-01	9.73e-03
KERATAN SULFATE DEGRADATION	11	3.10e-01	4.82e-01	0.27500	2.10e-01	0.178000	2.28e-01	3.06e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	7.98e-02	1.93e-01	0.27500	2.65e-01	0.074600	2.78e-02	5.36e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	5.62e-02	1.55e-01	0.27500	-1.16e-01	0.249000	3.25e-01	3.45e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	1.16e-03	8.33e-03	0.27500	8.28e-02	0.262000	2.60e-01	3.59e-04
FC EPSILON RECEPTOR FCERI SIGNALING	123	8.59e-07	2.20e-05	0.27400	-1.33e-02	0.274000	7.99e-01	1.53e-07
SARS COV 1 INFECTION	48	5.21e-03	2.64e-02	0.27400	6.65e-02	0.266000	4.25e-01	1.42e-03
PHASE 0 RAPID DEPOLARISATION	31	3.77e-02	1.18e-01	0.27400	-1.61e-01	-0.222000	1.20e-01	3.25e-02
INTERLEUKIN 1 SIGNALING	95	3.18e-05	4.37e-04	0.27400	6.66e-02	0.266000	2.62e-01	7.54e-06
FORMATION OF APOPTOSOME	10	3.00e-01	4.75e-01	0.27400	-1.55e-01	0.226000	3.95e-01	2.16e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	12	2.75e-01	4.52e-01	0.27300	-9.51e-02	-0.256000	5.68e-01	1.24e-01
BIOTIN TRANSPORT AND METABOLISM	11	3.12e-01	4.83e-01	0.27200	2.49e-01	0.111000	1.53e-01	5.25e-01
INTERLEUKIN 12 SIGNALING	37	1.59e-02	6.34e-02	0.27200	-1.32e-02	0.272000	8.89e-01	4.26e-03
N GLYCAN ANTENNAE ELONGATION	15	1.69e-01	3.34e-01	0.27200	-1.56e-01	0.223000	2.97e-01	1.35e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	1.28e-01	2.69e-01	0.27100	-2.03e-01	-0.180000	1.17e-01	1.64e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	1.50e-02	6.10e-02	0.27100	1.98e-01	0.185000	2.84e-02	4.09e-02
SPHINGOLIPID METABOLISM	79	1.68e-04	1.69e-03	0.27000	-7.27e-03	0.270000	9.11e-01	3.32e-05
PI 3K CASCADE FGFR1	15	2.02e-01	3.79e-01	0.27000	5.03e-02	0.265000	7.36e-01	7.58e-02
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	25	7.05e-02	1.79e-01	0.26900	5.64e-02	0.263000	6.25e-01	2.27e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	2.54e-01	4.29e-01	0.26900	7.07e-02	0.260000	6.59e-01	1.05e-01
COSTIMULATION BY THE CD28 FAMILY	48	3.80e-03	2.11e-02	0.26900	-1.57e-01	0.219000	6.03e-02	8.73e-03
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	4.14e-02	1.25e-01	0.26900	-8.91e-02	0.254000	4.15e-01	2.00e-02
PYRIMIDINE CATABOLISM	10	3.44e-01	5.17e-01	0.26900	-2.66e-01	-0.038800	1.45e-01	8.32e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	6.99e-02	1.78e-01	0.26800	-1.78e-01	0.200000	1.39e-01	9.63e-02
AMINE LIGAND BINDING RECEPTORS	31	2.88e-02	9.83e-02	0.26800	-2.35e-01	0.130000	2.38e-02	2.12e-01
SIGNALING BY CSF3 G CSF	29	3.80e-02	1.18e-01	0.26700	-1.11e-01	0.243000	3.00e-01	2.38e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	1.23e-01	2.60e-01	0.26700	-1.96e-01	-0.181000	1.19e-01	1.52e-01
TRANS GOLGI NETWORK VESICLE BUDDING	70	4.65e-04	3.93e-03	0.26700	-5.31e-02	0.261000	4.43e-01	1.57e-04
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	5.42e-02	1.52e-01	0.26600	-1.04e-01	0.245000	3.60e-01	3.04e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	8.66e-02	2.04e-01	0.26600	-9.55e-04	0.266000	9.94e-01	2.74e-02
THE NLRP3 INFLAMMASOME	15	1.84e-01	3.56e-01	0.26500	-1.49e-01	0.220000	3.18e-01	1.41e-01
SIGNALING BY INSULIN RECEPTOR	61	1.24e-03	8.65e-03	0.26500	-7.87e-02	0.253000	2.88e-01	6.33e-04
DNA REPLICATION PRE INITIATION	79	2.13e-04	2.02e-03	0.26500	-3.00e-02	0.263000	6.45e-01	5.25e-05
CYTOPROTECTION BY HMOX1	119	7.13e-06	1.28e-04	0.26500	1.08e-01	0.242000	4.27e-02	5.20e-06
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	2.60e-01	4.36e-01	0.26500	-1.46e-01	0.221000	3.81e-01	1.85e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	12	3.09e-01	4.81e-01	0.26400	2.17e-01	0.151000	1.94e-01	3.66e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	80	2.75e-04	2.47e-03	0.26400	3.51e-02	0.261000	5.88e-01	5.32e-05
INTERLEUKIN 12 FAMILY SIGNALING	44	1.12e-02	4.95e-02	0.26300	3.46e-02	0.261000	6.91e-01	2.77e-03
HSF1 DEPENDENT TRANSACTIVATION	34	3.03e-02	1.01e-01	0.26300	2.62e-01	0.023400	8.20e-03	8.14e-01
TCR SIGNALING	101	3.97e-05	5.14e-04	0.26200	4.54e-02	0.258000	4.31e-01	7.58e-06
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	89	1.55e-04	1.62e-03	0.26200	8.00e-02	0.249000	1.93e-01	4.88e-05
PEROXISOMAL LIPID METABOLISM	26	6.51e-02	1.70e-01	0.26200	-3.78e-02	0.259000	7.39e-01	2.23e-02
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	2.99e-01	4.75e-01	0.26100	-1.82e-01	0.187000	2.96e-01	2.83e-01
SIGNALING BY KIT IN DISEASE	20	1.15e-01	2.51e-01	0.26100	-2.30e-01	0.123000	7.50e-02	3.42e-01
FCERI MEDIATED CA 2 MOBILIZATION	26	7.09e-02	1.80e-01	0.26000	5.29e-03	0.260000	9.63e-01	2.16e-02
NEUTROPHIL DEGRANULATION	383	4.33e-17	3.36e-15	0.26000	2.96e-02	0.259000	3.21e-01	4.24e-18
VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	6.52e-02	1.70e-01	0.26000	-5.97e-02	0.253000	5.98e-01	2.54e-02
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	2.22e-02	7.97e-02	0.25900	-2.26e-01	-0.128000	1.35e-02	1.62e-01
CELL CELL JUNCTION ORGANIZATION	50	5.99e-03	2.93e-02	0.25900	-2.58e-01	0.024800	1.60e-03	7.62e-01
SIGNALING BY NOTCH4	83	2.92e-04	2.60e-03	0.25900	4.44e-02	0.255000	4.85e-01	6.01e-05
INWARDLY RECTIFYING K CHANNELS	31	3.90e-02	1.20e-01	0.25800	-8.70e-02	0.243000	4.02e-01	1.92e-02
INTERLEUKIN 10 SIGNALING	17	1.64e-01	3.26e-01	0.25700	-1.86e-01	0.177000	1.85e-01	2.06e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	1.21e-01	2.58e-01	0.25700	-1.43e-01	0.213000	2.67e-01	9.93e-02
DAP12 INTERACTIONS	29	4.84e-02	1.42e-01	0.25600	-1.14e-01	0.230000	2.87e-01	3.24e-02
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	22	1.02e-01	2.31e-01	0.25600	-1.02e-01	0.235000	4.07e-01	5.67e-02
ARACHIDONIC ACID METABOLISM	40	2.24e-02	7.98e-02	0.25500	5.94e-02	0.248000	5.16e-01	6.57e-03
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	1.12e-01	2.46e-01	0.25500	-1.99e-01	0.159000	1.14e-01	2.08e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	3.56e-01	5.23e-01	0.25400	2.15e-01	-0.136000	2.40e-01	4.57e-01
EARLY PHASE OF HIV LIFE CYCLE	14	2.44e-01	4.18e-01	0.25200	-1.09e-01	0.227000	4.80e-01	1.41e-01
POLO LIKE KINASE MEDIATED EVENTS	13	3.05e-01	4.79e-01	0.25100	2.40e-01	0.075100	1.35e-01	6.39e-01
RMTS METHYLATE HISTONE ARGININES	42	1.82e-02	6.99e-02	0.25100	2.50e-01	-0.015700	5.01e-03	8.61e-01
MET ACTIVATES RAS SIGNALING	10	3.67e-01	5.32e-01	0.25000	-2.10e-01	0.136000	2.50e-01	4.57e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	81	5.58e-04	4.49e-03	0.25000	2.67e-02	0.249000	6.78e-01	1.10e-04
SIGNALING BY ERBB2 ECD MUTANTS	16	2.09e-01	3.85e-01	0.25000	-7.58e-02	0.238000	6.00e-01	9.94e-02
METABOLISM OF COFACTORS	18	1.94e-01	3.68e-01	0.24900	4.86e-02	0.244000	7.21e-01	7.26e-02
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	29	5.71e-02	1.57e-01	0.24900	-2.22e-01	0.114000	3.90e-02	2.88e-01
IRE1ALPHA ACTIVATES CHAPERONES	49	1.33e-02	5.71e-02	0.24900	2.23e-01	0.111000	6.89e-03	1.80e-01
ATTENUATION PHASE	24	1.12e-01	2.46e-01	0.24900	2.46e-01	0.041600	3.73e-02	7.24e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	1.12e-01	2.46e-01	0.24900	3.90e-02	-0.246000	7.46e-01	4.12e-02
INTERLEUKIN 1 FAMILY SIGNALING	123	2.12e-05	3.20e-04	0.24800	9.48e-02	0.229000	6.96e-02	1.16e-05
GLUCAGON TYPE LIGAND RECEPTORS	23	1.14e-01	2.49e-01	0.24700	-5.54e-02	0.241000	6.46e-01	4.58e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	18	2.12e-01	3.87e-01	0.24700	1.23e-01	0.214000	3.66e-01	1.16e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	1.48e-09	5.74e-08	0.24600	2.29e-01	0.090000	1.31e-09	1.72e-02
MAPK6 MAPK4 SIGNALING	83	7.09e-04	5.44e-03	0.24500	5.56e-02	0.239000	3.82e-01	1.71e-04
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	20	1.62e-01	3.23e-01	0.24500	-1.29e-02	0.245000	9.20e-01	5.84e-02
PEROXISOMAL PROTEIN IMPORT	57	4.74e-03	2.48e-02	0.24400	-9.45e-02	0.225000	2.17e-01	3.31e-03
CD28 DEPENDENT PI3K AKT SIGNALING	19	1.91e-01	3.64e-01	0.24300	-2.40e-01	-0.039500	6.99e-02	7.65e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	4.19e-04	3.56e-03	0.24300	-3.38e-02	0.241000	5.88e-01	1.13e-04
LATE ENDOSOMAL MICROAUTOPHAGY	31	7.67e-02	1.89e-01	0.24300	1.83e-01	0.160000	7.82e-02	1.22e-01
COHESIN LOADING ONTO CHROMATIN	10	4.32e-01	5.90e-01	0.24300	1.08e-01	0.217000	5.53e-01	2.34e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	17	2.10e-01	3.85e-01	0.24300	-6.22e-02	0.235000	6.57e-01	9.41e-02
SIGNALING BY FLT3 FUSION PROTEINS	18	2.18e-01	3.93e-01	0.24300	-2.28e-01	-0.081900	9.35e-02	5.48e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	13	3.42e-01	5.17e-01	0.24200	1.59e-01	0.183000	3.21e-01	2.53e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	225	5.01e-09	1.83e-07	0.24200	4.33e-02	0.238000	2.63e-01	8.07e-10
ERKS ARE INACTIVATED	13	2.97e-01	4.74e-01	0.24200	-1.28e-01	0.205000	4.26e-01	2.00e-01
DAP12 SIGNALING	24	1.07e-01	2.39e-01	0.24100	-1.36e-01	0.199000	2.48e-01	9.12e-02
NEGATIVE REGULATION OF FGFR2 SIGNALING	27	9.77e-02	2.24e-01	0.24100	2.81e-02	0.240000	8.00e-01	3.12e-02
HEDGEHOG ON STATE	82	1.25e-03	8.65e-03	0.24100	1.40e-01	0.196000	2.82e-02	2.13e-03
EPHRIN SIGNALING	19	1.78e-01	3.48e-01	0.24100	-7.92e-02	0.227000	5.50e-01	8.65e-02
METABOLISM OF PORPHYRINS	19	1.79e-01	3.51e-01	0.24000	-7.36e-02	0.229000	5.79e-01	8.43e-02
HEME SIGNALING	44	2.86e-02	9.81e-02	0.24000	-1.49e-01	-0.188000	8.76e-02	3.08e-02
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	4.07e-01	5.64e-01	0.24000	1.12e-01	0.212000	5.20e-01	2.23e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	16	2.42e-01	4.17e-01	0.23900	-5.32e-02	0.233000	7.12e-01	1.06e-01
S PHASE	153	1.40e-06	3.40e-05	0.23900	-6.02e-02	0.231000	1.99e-01	8.25e-07
HOST INTERACTIONS OF HIV FACTORS	125	2.50e-05	3.60e-04	0.23800	1.06e-03	0.238000	9.84e-01	4.35e-06
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	11	4.09e-01	5.65e-01	0.23800	2.21e-01	0.087900	2.04e-01	6.14e-01
SIGNALING BY WNT IN CANCER	31	6.04e-02	1.63e-01	0.23800	-1.26e-01	0.202000	2.23e-01	5.20e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	33	5.12e-02	1.47e-01	0.23700	-1.97e-01	0.133000	5.06e-02	1.88e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	7.42e-02	1.86e-01	0.23700	-1.21e-01	0.204000	2.60e-01	5.75e-02
SELECTIVE AUTOPHAGY	72	3.59e-03	2.00e-02	0.23700	1.74e-01	0.160000	1.05e-02	1.91e-02
PROCESSING OF INTRONLESS PRE MRNAS	19	1.85e-01	3.58e-01	0.23600	2.02e-01	-0.122000	1.28e-01	3.59e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	2.00e-01	3.77e-01	0.23600	1.57e-01	-0.176000	2.50e-01	1.96e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	2.21e-01	3.96e-01	0.23500	1.91e-01	-0.138000	1.74e-01	3.24e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	4.25e-01	5.82e-01	0.23500	-1.44e-01	-0.186000	4.08e-01	2.86e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	2.07e-02	7.63e-02	0.23500	-1.18e-01	0.204000	1.77e-01	1.95e-02
PLASMA LIPOPROTEIN ASSEMBLY	11	3.78e-01	5.40e-01	0.23400	-1.65e-01	0.167000	3.44e-01	3.38e-01
FOXO MEDIATED TRANSCRIPTION	59	5.86e-03	2.88e-02	0.23400	-1.11e-01	0.206000	1.39e-01	6.25e-03
PKA MEDIATED PHOSPHORYLATION OF CREB	19	1.88e-01	3.62e-01	0.23400	-1.48e-01	0.181000	2.64e-01	1.71e-01
METALLOPROTEASE DUBS	25	1.22e-01	2.60e-01	0.23400	-4.14e-02	0.230000	7.20e-01	4.67e-02
REGULATION OF IFNA SIGNALING	12	3.99e-01	5.57e-01	0.23300	-1.96e-01	-0.126000	2.40e-01	4.50e-01
DISEASES OF MITOTIC CELL CYCLE	37	5.54e-02	1.54e-01	0.23200	-2.25e-01	-0.055400	1.79e-02	5.60e-01
REGULATION OF KIT SIGNALING	16	2.88e-01	4.67e-01	0.23200	-2.23e-01	-0.062200	1.22e-01	6.67e-01
MITOTIC TELOPHASE CYTOKINESIS	13	3.74e-01	5.37e-01	0.23200	1.95e-01	0.124000	2.23e-01	4.37e-01
VOLTAGE GATED POTASSIUM CHANNELS	40	5.03e-02	1.46e-01	0.23100	-1.40e-01	-0.183000	1.25e-01	4.50e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	3.30e-01	5.04e-01	0.23000	-1.68e-01	0.157000	2.94e-01	3.26e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	2.93e-02	9.94e-02	0.22900	1.73e-01	0.150000	3.81e-02	7.17e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	3.64e-01	5.29e-01	0.22800	-1.74e-02	-0.228000	9.14e-01	1.55e-01
SIGNALING BY NTRK3 TRKC	17	2.42e-01	4.17e-01	0.22800	1.29e-01	-0.188000	3.58e-01	1.79e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	1.81e-03	1.17e-02	0.22800	2.25e-01	-0.038000	5.46e-04	5.59e-01
GABA B RECEPTOR ACTIVATION	39	4.35e-02	1.29e-01	0.22800	-4.73e-02	0.223000	6.10e-01	1.60e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	88	1.65e-03	1.08e-02	0.22800	1.28e-01	0.189000	3.83e-02	2.25e-03
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	6.95e-02	1.77e-01	0.22800	-2.27e-01	0.009320	2.17e-02	9.25e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	1.76e-01	3.46e-01	0.22700	-1.70e-01	-0.151000	1.49e-01	2.02e-01
INTRAFLAGELLAR TRANSPORT	49	1.91e-02	7.15e-02	0.22700	7.94e-02	-0.212000	3.36e-01	1.01e-02
TRANSCRIPTIONAL REGULATION BY RUNX3	92	1.12e-03	8.10e-03	0.22600	5.57e-02	0.219000	3.56e-01	2.89e-04
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	30	1.04e-01	2.33e-01	0.22500	2.25e-01	0.016100	3.33e-02	8.78e-01
SIGNALING BY FGFR2 IIIA TM	19	2.49e-01	4.23e-01	0.22500	6.70e-02	0.215000	6.13e-01	1.05e-01
SIGNALING BY FGFR1	43	3.81e-02	1.18e-01	0.22500	1.28e-04	0.225000	9.99e-01	1.08e-02
PARASITE INFECTION	55	1.35e-02	5.76e-02	0.22500	-5.25e-02	0.219000	5.01e-01	5.07e-03
CD209 DC SIGN SIGNALING	18	2.43e-01	4.18e-01	0.22400	-6.93e-02	0.213000	6.11e-01	1.18e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	4.63e-01	6.17e-01	0.22400	-3.45e-02	0.221000	8.50e-01	2.26e-01
RHOBTB GTPASE CYCLE	35	8.57e-02	2.03e-01	0.22300	1.29e-01	0.182000	1.87e-01	6.18e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	3.41e-01	5.16e-01	0.22300	-2.08e-01	-0.080500	1.62e-01	5.89e-01
GLYCOSPHINGOLIPID METABOLISM	38	5.57e-02	1.54e-01	0.22300	-2.51e-02	0.222000	7.89e-01	1.81e-02
DNA DAMAGE BYPASS	46	3.14e-02	1.04e-01	0.22300	-2.23e-01	0.009390	8.94e-03	9.12e-01
RHO GTPASES ACTIVATE PAKS	21	2.32e-01	4.07e-01	0.22300	1.57e-01	0.158000	2.12e-01	2.10e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	4.80e-04	4.00e-03	0.22300	1.46e-01	-0.168000	1.33e-02	4.43e-03
EPHB MEDIATED FORWARD SIGNALING	42	3.63e-02	1.14e-01	0.22300	-1.09e-01	0.194000	2.20e-01	2.97e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS	26	1.34e-01	2.78e-01	0.22200	-2.11e-01	0.070100	6.28e-02	5.36e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	51	2.29e-02	8.10e-02	0.22200	-3.24e-03	-0.222000	9.68e-01	6.07e-03
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	9.58e-02	2.20e-01	0.22200	-2.19e-01	0.037600	3.53e-02	7.17e-01
IRS MEDIATED SIGNALLING	37	5.83e-02	1.59e-01	0.22100	-6.91e-02	0.210000	4.67e-01	2.68e-02
INNATE IMMUNE SYSTEM	771	9.18e-24	1.78e-21	0.22000	1.85e-02	0.219000	3.85e-01	7.12e-25
HDR THROUGH MMEJ ALT NHEJ	10	4.63e-01	6.17e-01	0.21900	1.83e-01	-0.121000	3.16e-01	5.09e-01
UNWINDING OF DNA	12	4.08e-01	5.65e-01	0.21900	-2.13e-01	0.052800	2.02e-01	7.51e-01
REGULATED PROTEOLYSIS OF P75NTR	12	4.38e-01	5.96e-01	0.21900	7.74e-02	0.205000	6.43e-01	2.20e-01
SIGNALING BY FGFR2 IN DISEASE	36	7.75e-02	1.91e-01	0.21900	1.91e-02	0.218000	8.43e-01	2.37e-02
INTERFERON GAMMA SIGNALING	73	5.35e-03	2.69e-02	0.21800	-2.18e-01	0.009670	1.31e-03	8.86e-01
LYSINE CATABOLISM	11	4.74e-01	6.29e-01	0.21800	2.01e-01	0.084600	2.49e-01	6.27e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	3.39e-01	5.13e-01	0.21800	-2.17e-01	0.017400	1.46e-01	9.07e-01
HDACS DEACETYLATE HISTONES	45	3.26e-02	1.07e-01	0.21700	1.52e-01	-0.156000	7.86e-02	7.03e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	28	1.20e-01	2.58e-01	0.21700	-1.64e-01	0.142000	1.33e-01	1.93e-01
HEME BIOSYNTHESIS	13	3.74e-01	5.37e-01	0.21700	-1.26e-01	0.177000	4.32e-01	2.70e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	140	3.93e-05	5.14e-04	0.21700	-5.02e-02	0.211000	3.06e-01	1.67e-05
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	3.24e-01	4.96e-01	0.21700	1.84e-01	-0.115000	2.18e-01	4.40e-01
FCERI MEDIATED MAPK ACTIVATION	28	1.33e-01	2.78e-01	0.21700	-2.84e-02	0.215000	7.95e-01	4.91e-02
PCP CE PATHWAY	90	2.43e-03	1.49e-02	0.21700	8.16e-02	0.201000	1.81e-01	1.01e-03
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	2.60e-01	4.36e-01	0.21700	1.88e-01	-0.108000	1.68e-01	4.29e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	10	5.15e-01	6.63e-01	0.21700	-1.11e-01	-0.186000	5.44e-01	3.09e-01
LONG TERM POTENTIATION	23	2.22e-01	3.98e-01	0.21600	-1.65e-01	-0.140000	1.72e-01	2.46e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	24	2.05e-01	3.82e-01	0.21600	9.73e-02	0.192000	4.09e-01	1.03e-01
OPIOID SIGNALLING	86	1.95e-03	1.24e-02	0.21500	-7.33e-02	0.202000	2.40e-01	1.18e-03
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	4.46e-01	6.03e-01	0.21500	5.28e-02	0.208000	7.51e-01	2.11e-01
PROCESSING OF SMDT1	16	3.07e-01	4.80e-01	0.21400	-1.72e-01	0.127000	2.32e-01	3.78e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	3.00e-01	4.75e-01	0.21400	-2.11e-01	0.039600	1.33e-01	7.78e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	59	2.20e-02	7.94e-02	0.21400	-1.90e-01	-0.098300	1.18e-02	1.92e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	4.35e-01	5.92e-01	0.21400	-1.40e-02	0.213000	9.33e-01	2.01e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	3.79e-02	1.18e-01	0.21300	-1.72e-01	0.126000	4.66e-02	1.43e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	7.45e-02	1.86e-01	0.21200	-1.19e-02	0.212000	8.99e-01	2.37e-02
INTERLEUKIN 27 SIGNALING	10	5.31e-01	6.70e-01	0.21200	1.75e-01	0.119000	3.38e-01	5.14e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	82	5.13e-03	2.64e-02	0.21100	6.04e-02	0.202000	3.45e-01	1.55e-03
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	12	4.51e-01	6.07e-01	0.21100	2.10e-01	0.015500	2.07e-01	9.26e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	34	1.21e-01	2.58e-01	0.21100	1.62e-01	0.135000	1.02e-01	1.74e-01
ADHERENS JUNCTIONS INTERACTIONS	30	1.37e-01	2.82e-01	0.21000	-2.10e-01	-0.007220	4.62e-02	9.45e-01
PLASMA LIPOPROTEIN CLEARANCE	26	1.89e-01	3.63e-01	0.21000	5.75e-02	0.202000	6.12e-01	7.41e-02
INTEGRIN SIGNALING	24	2.23e-01	3.98e-01	0.21000	1.05e-01	0.182000	3.74e-01	1.23e-01
PERK REGULATES GENE EXPRESSION	28	1.55e-01	3.11e-01	0.20900	-1.28e-02	0.209000	9.07e-01	5.55e-02
DISEASES OF IMMUNE SYSTEM	23	2.44e-01	4.19e-01	0.20900	1.49e-01	0.146000	2.15e-01	2.24e-01
REGULATION OF BACH1 ACTIVITY	11	4.78e-01	6.32e-01	0.20800	-4.26e-02	0.204000	8.07e-01	2.42e-01
SIGNALING BY ERYTHROPOIETIN	24	2.23e-01	3.98e-01	0.20800	6.39e-02	0.198000	5.88e-01	9.30e-02
SIALIC ACID METABOLISM	32	1.07e-01	2.41e-01	0.20800	-1.51e-01	0.144000	1.40e-01	1.60e-01
RESOLUTION OF D LOOP STRUCTURES	30	1.60e-01	3.20e-01	0.20800	-1.03e-01	-0.181000	3.31e-01	8.70e-02
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	3.29e-01	5.03e-01	0.20800	-1.44e-01	0.149000	3.18e-01	3.01e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	3.05e-01	4.79e-01	0.20700	5.38e-02	0.200000	6.85e-01	1.31e-01
TRNA AMINOACYLATION	42	7.36e-02	1.85e-01	0.20700	2.01e-01	0.049800	2.46e-02	5.76e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	26	2.09e-01	3.85e-01	0.20600	1.00e-01	0.180000	3.76e-01	1.12e-01
FCGR3A MEDIATED IL10 SYNTHESIS	32	1.37e-01	2.82e-01	0.20600	3.96e-02	0.202000	6.98e-01	4.80e-02
COPII MEDIATED VESICLE TRANSPORT	66	1.15e-02	5.02e-02	0.20600	-1.70e-01	0.116000	1.68e-02	1.04e-01
DNA REPLICATION	121	3.90e-04	3.34e-03	0.20500	-4.17e-02	0.201000	4.28e-01	1.35e-04
CELLULAR HEXOSE TRANSPORT	11	5.21e-01	6.63e-01	0.20500	-1.71e-01	-0.113000	3.25e-01	5.18e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	3.70e-01	5.35e-01	0.20500	-7.61e-02	0.190000	6.10e-01	2.02e-01
SIGNALING BY EGFR IN CANCER	22	2.51e-01	4.26e-01	0.20500	7.54e-03	0.205000	9.51e-01	9.68e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	3.91e-01	5.51e-01	0.20500	1.15e-01	-0.169000	4.56e-01	2.73e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	3.99e-01	5.57e-01	0.20400	-4.08e-02	-0.200000	7.85e-01	1.79e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	15	3.73e-01	5.36e-01	0.20400	-1.91e-01	0.073600	2.01e-01	6.22e-01
HSF1 ACTIVATION	26	2.18e-01	3.93e-01	0.20400	1.15e-01	0.169000	3.12e-01	1.36e-01
INTERLEUKIN 7 SIGNALING	20	3.08e-01	4.81e-01	0.20400	-9.90e-02	-0.178000	4.43e-01	1.68e-01
REGULATION OF SIGNALING BY CBL	22	2.63e-01	4.39e-01	0.20400	4.29e-02	0.199000	7.28e-01	1.06e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	3.93e-01	5.52e-01	0.20400	-1.42e-01	0.146000	3.58e-01	3.44e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	3.57e-01	5.23e-01	0.20400	4.33e-02	0.199000	7.57e-01	1.56e-01
UCH PROTEINASES	88	5.44e-03	2.72e-02	0.20400	7.19e-02	0.190000	2.44e-01	2.03e-03
MATURATION OF NUCLEOPROTEIN	10	5.59e-01	6.93e-01	0.20400	-1.59e-01	-0.127000	3.85e-01	4.86e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	26	2.05e-01	3.82e-01	0.20300	2.60e-02	0.202000	8.19e-01	7.53e-02
RHOH GTPASE CYCLE	37	9.56e-02	2.20e-01	0.20300	-3.54e-02	0.200000	7.09e-01	3.54e-02
REGULATED NECROSIS	45	6.19e-02	1.66e-01	0.20200	-1.30e-02	0.201000	8.80e-01	1.94e-02
PLATELET CALCIUM HOMEOSTASIS	25	2.40e-01	4.15e-01	0.20100	-1.71e-01	-0.105000	1.38e-01	3.62e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	24	2.10e-01	3.85e-01	0.20100	-1.48e-01	0.136000	2.10e-01	2.48e-01
INFECTIOUS DISEASE	727	2.04e-18	1.83e-16	0.20000	4.80e-02	0.194000	2.84e-02	6.32e-19
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	3.61e-02	1.14e-01	0.20000	1.07e-01	0.169000	1.54e-01	2.50e-02
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	5.19e-01	6.63e-01	0.20000	1.22e-02	0.200000	9.44e-01	2.52e-01
METAL ION SLC TRANSPORTERS	24	2.15e-01	3.92e-01	0.20000	-1.20e-01	0.160000	3.09e-01	1.76e-01
KERATAN SULFATE BIOSYNTHESIS	24	2.36e-01	4.11e-01	0.19900	-8.45e-03	0.199000	9.43e-01	9.11e-02
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	93	2.94e-03	1.74e-02	0.19900	-9.01e-02	0.177000	1.33e-01	3.12e-03
ACYL CHAIN REMODELLING OF PE	16	3.61e-01	5.25e-01	0.19900	-1.27e-01	0.153000	3.80e-01	2.89e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	17	3.45e-01	5.17e-01	0.19900	-8.36e-02	0.180000	5.51e-01	1.99e-01
PURINE SALVAGE	12	4.91e-01	6.47e-01	0.19900	3.79e-03	0.199000	9.82e-01	2.34e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	5.34e-01	6.70e-01	0.19800	-1.91e-01	-0.054500	2.73e-01	7.54e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	8.72e-03	4.00e-02	0.19800	6.36e-02	0.188000	3.14e-01	2.94e-03
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	2.73e-01	4.51e-01	0.19800	1.85e-01	0.070800	1.24e-01	5.57e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	1.16e-01	2.52e-01	0.19800	1.64e-01	0.111000	7.59e-02	2.31e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	110	1.40e-03	9.53e-03	0.19800	-2.33e-02	0.197000	6.73e-01	3.67e-04
METABOLISM OF RNA	643	1.58e-15	1.02e-13	0.19800	1.62e-01	0.114000	3.15e-12	1.00e-06
GP1B IX V ACTIVATION SIGNALLING	11	5.04e-01	6.56e-01	0.19800	9.26e-02	-0.175000	5.95e-01	3.16e-01
SPRY REGULATION OF FGF SIGNALING	16	3.84e-01	5.46e-01	0.19700	-2.57e-02	0.196000	8.59e-01	1.75e-01
RHO GTPASES ACTIVATE PKNS	47	6.36e-02	1.68e-01	0.19700	-9.67e-05	0.197000	9.99e-01	1.92e-02
G ALPHA I SIGNALLING EVENTS	193	7.33e-06	1.28e-04	0.19700	-9.72e-02	0.171000	2.00e-02	4.17e-05
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	3.48e-01	5.19e-01	0.19700	1.27e-01	-0.150000	3.64e-01	2.85e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	7.56e-02	1.88e-01	0.19600	5.13e-02	-0.190000	5.61e-01	3.15e-02
NON INTEGRIN MEMBRANE ECM INTERACTIONS	55	4.31e-02	1.28e-01	0.19600	1.95e-01	0.019500	1.22e-02	8.02e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	2.98e-01	4.75e-01	0.19600	1.85e-01	-0.065600	1.52e-01	6.12e-01
LAGGING STRAND SYNTHESIS	20	3.31e-01	5.04e-01	0.19600	6.61e-02	0.184000	6.09e-01	1.53e-01
MUCOPOLYSACCHARIDOSES	11	5.12e-01	6.61e-01	0.19600	-8.01e-02	0.179000	6.46e-01	3.05e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	42	8.48e-02	2.01e-01	0.19600	-2.68e-02	0.194000	7.64e-01	2.97e-02
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	5.51e-03	2.74e-02	0.19600	1.19e-01	-0.155000	5.77e-02	1.35e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX	105	1.64e-03	1.08e-02	0.19500	1.46e-01	-0.129000	9.67e-03	2.21e-02
PROLACTIN RECEPTOR SIGNALING	11	5.26e-01	6.66e-01	0.19500	-2.46e-02	0.194000	8.88e-01	2.66e-01
SYNTHESIS OF PC	25	2.58e-01	4.34e-01	0.19500	8.24e-02	0.177000	4.76e-01	1.26e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	6.36e-02	1.68e-01	0.19500	1.92e-01	-0.034900	2.28e-02	6.79e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	3.44e-01	5.17e-01	0.19400	1.73e-01	0.087200	1.80e-01	5.00e-01
INSULIN RECEPTOR SIGNALLING CASCADE	42	8.29e-02	1.98e-01	0.19400	-7.65e-02	0.178000	3.91e-01	4.60e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	50	5.22e-02	1.49e-01	0.19400	7.28e-02	-0.179000	3.73e-01	2.83e-02
NRAGE SIGNALS DEATH THROUGH JNK	56	3.52e-02	1.12e-01	0.19300	1.19e-01	-0.152000	1.23e-01	4.95e-02
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	7.73e-02	1.91e-01	0.19300	1.06e-01	0.161000	2.01e-01	5.11e-02
PEPTIDE HORMONE METABOLISM	58	3.20e-02	1.05e-01	0.19300	-1.09e-01	0.159000	1.50e-01	3.68e-02
TRANSLESION SYNTHESIS BY POLH	19	3.54e-01	5.23e-01	0.19200	2.77e-02	0.190000	8.34e-01	1.51e-01
HEDGEHOG OFF STATE	106	4.28e-03	2.33e-02	0.19200	1.40e-01	0.131000	1.27e-02	1.95e-02
SARS COV INFECTIONS	139	5.56e-04	4.49e-03	0.19200	3.19e-02	0.189000	5.16e-01	1.17e-04
GENERATION OF SECOND MESSENGER MOLECULES	20	3.45e-01	5.17e-01	0.19200	5.93e-02	0.183000	6.46e-01	1.57e-01
TELOMERE EXTENSION BY TELOMERASE	23	2.61e-01	4.36e-01	0.19200	8.57e-02	-0.172000	4.77e-01	1.54e-01
RHO GTPASES ACTIVATE IQGAPS	24	2.93e-01	4.72e-01	0.19100	1.38e-01	0.133000	2.43e-01	2.61e-01
PHASE 2 PLATEAU PHASE	13	5.00e-01	6.52e-01	0.19100	-4.22e-02	-0.186000	7.92e-01	2.45e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	3.45e-01	5.17e-01	0.19100	-1.89e-01	0.028900	1.55e-01	8.27e-01
O LINKED GLYCOSYLATION OF MUCINS	40	1.08e-01	2.41e-01	0.19100	-1.89e-01	0.023100	3.85e-02	8.01e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	2.25e-01	3.99e-01	0.19000	-7.96e-02	0.173000	4.82e-01	1.28e-01
INTERFERON SIGNALING	160	1.84e-04	1.77e-03	0.19000	-1.90e-01	-0.001910	3.47e-05	9.67e-01
IRAK1 RECRUITS IKK COMPLEX	14	4.94e-01	6.47e-01	0.19000	1.28e-01	0.140000	4.08e-01	3.64e-01
AUTOPHAGY	138	9.64e-04	7.16e-03	0.18900	9.95e-02	0.161000	4.38e-02	1.09e-03
SIGNALING BY FGFR2	64	4.12e-02	1.25e-01	0.18900	1.24e-01	0.142000	8.60e-02	4.92e-02
NGF STIMULATED TRANSCRIPTION	37	1.20e-01	2.58e-01	0.18900	-1.27e-01	0.139000	1.80e-01	1.43e-01
REGULATION OF FZD BY UBIQUITINATION	19	3.44e-01	5.17e-01	0.18900	-7.09e-02	0.175000	5.93e-01	1.87e-01
SEPARATION OF SISTER CHROMATIDS	164	2.38e-04	2.22e-03	0.18900	5.92e-02	0.179000	1.92e-01	7.76e-05
FGFR2 ALTERNATIVE SPLICING	26	2.37e-01	4.12e-01	0.18800	1.80e-01	-0.055600	1.12e-01	6.24e-01
SODIUM CALCIUM EXCHANGERS	10	5.70e-01	7.02e-01	0.18800	-1.70e-01	0.080100	3.51e-01	6.61e-01
UNFOLDED PROTEIN RESPONSE UPR	85	1.53e-02	6.19e-02	0.18800	1.21e-01	0.143000	5.32e-02	2.27e-02
SIGNALING BY ACTIVIN	12	5.20e-01	6.63e-01	0.18800	-1.83e-01	0.041300	2.73e-01	8.04e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	24	2.97e-01	4.74e-01	0.18800	6.37e-02	0.176000	5.89e-01	1.35e-01
POLYMERASE SWITCHING	14	4.98e-01	6.51e-01	0.18700	9.10e-02	0.164000	5.55e-01	2.88e-01
AURKA ACTIVATION BY TPX2	71	1.91e-02	7.15e-02	0.18700	9.35e-02	-0.162000	1.73e-01	1.82e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	5.79e-01	7.07e-01	0.18700	-1.79e-01	0.052700	3.26e-01	7.73e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	5.72e-01	7.03e-01	0.18700	-1.59e-01	0.098400	3.84e-01	5.90e-01
NEDDYLATION	216	6.45e-06	1.19e-04	0.18700	-1.06e-01	0.154000	7.32e-03	1.00e-04
NCAM SIGNALING FOR NEURITE OUT GROWTH	59	3.79e-02	1.18e-01	0.18700	9.40e-02	-0.161000	2.12e-01	3.23e-02
ENDOGENOUS STEROLS	21	3.50e-01	5.20e-01	0.18700	1.74e-01	0.068000	1.68e-01	5.89e-01
SIGNALING BY TGFB FAMILY MEMBERS	96	5.05e-03	2.62e-02	0.18600	-9.35e-02	0.161000	1.14e-01	6.44e-03
CELLULAR RESPONSES TO EXTERNAL STIMULI	596	6.81e-13	3.61e-11	0.18600	9.70e-02	0.158000	5.65e-05	4.97e-11
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	2.30e-01	4.04e-01	0.18500	-7.51e-02	0.170000	5.00e-01	1.27e-01
PROGRAMMED CELL DEATH	184	8.18e-05	9.35e-04	0.18500	3.62e-03	0.185000	9.33e-01	1.47e-05
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	3.55e-01	5.23e-01	0.18500	-1.63e-01	0.087000	2.17e-01	5.12e-01
MITOTIC METAPHASE AND ANAPHASE	204	4.56e-05	5.71e-04	0.18500	5.18e-02	0.177000	2.03e-01	1.27e-05
RHOQ GTPASE CYCLE	58	6.05e-02	1.63e-01	0.18400	6.65e-02	0.171000	3.81e-01	2.40e-02
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	1.53e-02	6.19e-02	0.18300	9.93e-02	-0.154000	1.30e-01	1.87e-02
KERATAN SULFATE KERATIN METABOLISM	30	2.24e-01	3.99e-01	0.18300	1.00e-02	0.182000	9.24e-01	8.38e-02
PLATELET AGGREGATION PLUG FORMATION	33	2.12e-01	3.88e-01	0.18300	1.01e-01	0.152000	3.14e-01	1.31e-01
APOPTOSIS	162	3.43e-04	3.00e-03	0.18200	8.91e-03	0.182000	8.45e-01	6.50e-05
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	3.19e-01	4.91e-01	0.18200	-1.82e-01	-0.005250	1.31e-01	9.65e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	2.26e-02	8.01e-02	0.18200	-9.62e-02	0.154000	1.58e-01	2.38e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	5.33e-01	6.70e-01	0.18100	1.03e-01	-0.149000	5.37e-01	3.72e-01
HDMS DEMETHYLATE HISTONES	27	2.84e-01	4.62e-01	0.18100	-7.01e-02	-0.166000	5.29e-01	1.34e-01
G ALPHA Z SIGNALLING EVENTS	45	1.03e-01	2.33e-01	0.18100	-3.75e-02	0.177000	6.64e-01	4.03e-02
TRANSCRIPTIONAL REGULATION BY MECP2	60	6.50e-02	1.70e-01	0.18100	-1.22e-01	-0.133000	1.01e-01	7.54e-02
RHOA GTPASE CYCLE	143	1.04e-03	7.66e-03	0.18000	1.80e-01	0.017000	2.12e-04	7.26e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	4.62e-02	1.36e-01	0.18000	-1.32e-01	0.123000	7.96e-02	1.04e-01
HIV INFECTION	221	2.58e-05	3.67e-04	0.18000	1.27e-02	0.180000	7.45e-01	4.30e-06
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	26	2.76e-01	4.53e-01	0.18000	1.78e-01	-0.023000	1.16e-01	8.39e-01
SIGNALING BY PDGFR IN DISEASE	20	3.56e-01	5.23e-01	0.18000	-9.96e-02	0.149000	4.41e-01	2.47e-01
PROTEIN FOLDING	88	1.85e-02	7.04e-02	0.18000	9.38e-02	0.153000	1.29e-01	1.31e-02
ERBB2 ACTIVATES PTK6 SIGNALING	11	6.10e-01	7.29e-01	0.17900	-1.28e-01	-0.125000	4.61e-01	4.73e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA	12	5.57e-01	6.92e-01	0.17900	-1.78e-01	0.013000	2.84e-01	9.38e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	30	2.26e-01	3.99e-01	0.17900	-1.74e-01	0.042400	1.00e-01	6.88e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	62	5.27e-02	1.50e-01	0.17800	6.83e-03	0.178000	9.26e-01	1.53e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	76	2.50e-02	8.66e-02	0.17800	-2.98e-02	0.175000	6.53e-01	8.26e-03
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	284	7.17e-07	1.94e-05	0.17800	-1.48e-01	0.097800	1.74e-05	4.66e-03
SIGNALING BY INTERLEUKINS	345	1.59e-07	5.00e-06	0.17800	3.33e-02	0.174000	2.90e-01	2.77e-08
DSCAM INTERACTIONS	11	6.11e-01	7.29e-01	0.17700	-7.15e-02	-0.162000	6.81e-01	3.52e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	1.21e-01	2.58e-01	0.17700	-6.45e-02	0.164000	4.64e-01	6.21e-02
PLASMA LIPOPROTEIN REMODELING	15	5.07e-01	6.58e-01	0.17600	-1.71e-01	-0.041100	2.51e-01	7.83e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	4.17e-01	5.73e-01	0.17500	-6.85e-02	0.161000	6.15e-01	2.36e-01
SIGNALING BY MET	75	4.00e-02	1.22e-01	0.17500	1.24e-01	0.124000	6.30e-02	6.41e-02
UB SPECIFIC PROCESSING PROTEASES	166	4.92e-04	4.07e-03	0.17500	-5.14e-03	0.175000	9.09e-01	1.03e-04
EXTRACELLULAR MATRIX ORGANIZATION	239	1.54e-05	2.47e-04	0.17500	1.72e-01	-0.029800	4.80e-06	4.28e-01
CILIUM ASSEMBLY	189	1.18e-04	1.26e-03	0.17300	1.25e-01	-0.120000	3.10e-03	4.48e-03
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	34	1.94e-01	3.68e-01	0.17300	1.29e-01	-0.115000	1.92e-01	2.46e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	5.28e-01	6.67e-01	0.17300	-1.73e-01	0.012900	2.63e-01	9.33e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	6.23e-02	1.66e-01	0.17300	1.62e-01	-0.060400	3.13e-02	4.22e-01
G2 M CHECKPOINTS	133	2.02e-03	1.28e-02	0.17300	-5.50e-02	0.164000	2.74e-01	1.10e-03
RHOG GTPASE CYCLE	73	4.58e-02	1.35e-01	0.17300	7.69e-02	0.155000	2.56e-01	2.25e-02
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	4.70e-01	6.25e-01	0.17200	7.28e-02	-0.156000	6.14e-01	2.79e-01
ERK MAPK TARGETS	22	3.50e-01	5.20e-01	0.17200	-1.41e-01	0.099500	2.53e-01	4.19e-01
BASE EXCISION REPAIR AP SITE FORMATION	29	2.54e-01	4.29e-01	0.17200	9.66e-02	-0.142000	3.68e-01	1.85e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	5.43e-01	6.80e-01	0.17200	-1.49e-01	0.084500	3.51e-01	5.98e-01
BASIGIN INTERACTIONS	22	3.59e-01	5.24e-01	0.17200	-6.82e-02	0.157000	5.80e-01	2.01e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	2.69e-01	4.45e-01	0.17100	1.46e-01	-0.088900	1.80e-01	4.16e-01
ACTIVATION OF BH3 ONLY PROTEINS	28	2.94e-01	4.74e-01	0.17100	-1.71e-01	-0.007830	1.18e-01	9.43e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	2.69e-01	4.45e-01	0.17100	-1.18e-01	0.123000	2.80e-01	2.58e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	138	2.50e-03	1.52e-02	0.17100	1.97e-03	0.171000	9.68e-01	5.49e-04
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	177	6.38e-04	4.96e-03	0.17000	4.71e-02	0.163000	2.80e-01	1.79e-04
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	341	1.77e-07	5.43e-06	0.17000	-1.13e-01	0.127000	3.59e-04	5.71e-05
CARGO CONCENTRATION IN THE ER	31	2.39e-01	4.15e-01	0.17000	-1.08e-01	0.131000	2.99e-01	2.08e-01
INTEGRIN CELL SURFACE INTERACTIONS	68	5.05e-02	1.46e-01	0.16900	1.68e-01	-0.022800	1.67e-02	7.45e-01
ACYL CHAIN REMODELLING OF PG	10	6.31e-01	7.43e-01	0.16900	-1.11e-01	0.128000	5.44e-01	4.84e-01
CHROMATIN MODIFYING ENZYMES	217	6.30e-05	7.50e-04	0.16900	6.46e-02	-0.156000	1.02e-01	7.55e-05
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	3.03e-01	4.77e-01	0.16900	1.09e-01	0.128000	3.00e-01	2.24e-01
LAMININ INTERACTIONS	27	3.05e-01	4.79e-01	0.16800	1.64e-01	-0.038800	1.41e-01	7.27e-01
RA BIOSYNTHESIS PATHWAY	12	5.80e-01	7.07e-01	0.16800	-9.34e-02	0.140000	5.76e-01	4.01e-01
NEGATIVE REGULATION OF MET ACTIVITY	21	3.98e-01	5.57e-01	0.16800	-4.29e-02	0.162000	7.34e-01	1.98e-01
CDC42 GTPASE CYCLE	153	1.16e-03	8.33e-03	0.16800	1.54e-01	-0.065800	9.95e-04	1.61e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	5.15e-01	6.63e-01	0.16700	-1.66e-01	-0.023600	2.51e-01	8.70e-01
O LINKED GLYCOSYLATION	85	3.64e-02	1.14e-01	0.16700	-1.13e-01	-0.123000	7.15e-02	5.02e-02
SIGNALING BY FGFR1 IN DISEASE	32	2.66e-01	4.41e-01	0.16700	1.21e-02	0.166000	9.06e-01	1.04e-01
SIGNALING BY FGFR IN DISEASE	55	1.08e-01	2.41e-01	0.16600	3.36e-02	0.163000	6.67e-01	3.65e-02
METABOLISM OF NUCLEOTIDES	91	1.87e-02	7.05e-02	0.16600	-7.33e-02	0.149000	2.27e-01	1.39e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	3.14e-01	4.85e-01	0.16600	-3.75e-02	0.162000	7.36e-01	1.45e-01
PLATELET HOMEOSTASIS	76	3.46e-02	1.11e-01	0.16600	-1.17e-01	0.118000	7.84e-02	7.54e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	4.35e-01	5.92e-01	0.16600	-1.44e-01	0.082600	2.79e-01	5.33e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	34	2.42e-01	4.18e-01	0.16600	-1.37e-02	0.165000	8.90e-01	9.61e-02
SIGNALING BY VEGF	102	1.63e-02	6.47e-02	0.16500	1.72e-02	0.164000	7.64e-01	4.13e-03
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	29	3.10e-01	4.81e-01	0.16500	2.02e-02	0.164000	8.50e-01	1.26e-01
TOLL LIKE RECEPTOR CASCADES	137	3.36e-03	1.90e-02	0.16500	-2.44e-02	0.163000	6.22e-01	9.78e-04
MTORC1 MEDIATED SIGNALLING	24	3.90e-01	5.51e-01	0.16500	5.28e-02	0.156000	6.54e-01	1.85e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	5.81e-01	7.07e-01	0.16500	-7.08e-02	-0.149000	6.47e-01	3.35e-01
FORMATION OF THE CORNIFIED ENVELOPE	28	2.96e-01	4.74e-01	0.16500	1.31e-01	-0.099000	2.29e-01	3.65e-01
KERATINIZATION	28	2.96e-01	4.74e-01	0.16500	1.31e-01	-0.099000	2.29e-01	3.65e-01
AMYLOID FIBER FORMATION	56	9.97e-02	2.27e-01	0.16400	-1.72e-02	0.163000	8.24e-01	3.44e-02
RND3 GTPASE CYCLE	38	2.17e-01	3.93e-01	0.16400	-5.56e-03	-0.164000	9.53e-01	8.05e-02
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	2.49e-01	4.23e-01	0.16400	-1.12e-01	-0.120000	2.38e-01	2.08e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	178	6.01e-04	4.73e-03	0.16400	-5.47e-02	0.154000	2.09e-01	3.93e-04
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	5.52e-01	6.88e-01	0.16300	1.18e-02	0.163000	9.37e-01	2.76e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	37	2.24e-01	3.99e-01	0.16300	-1.62e-01	0.013800	8.74e-02	8.84e-01
OTHER SEMAPHORIN INTERACTIONS	19	4.93e-01	6.47e-01	0.16300	-1.06e-01	-0.124000	4.25e-01	3.50e-01
METABOLISM OF CARBOHYDRATES	258	3.68e-05	4.93e-04	0.16200	-1.24e-02	0.162000	7.32e-01	7.78e-06
RHOC GTPASE CYCLE	73	5.22e-02	1.49e-01	0.16200	1.58e-01	-0.036100	1.99e-02	5.94e-01
TP53 REGULATES METABOLIC GENES	84	3.16e-02	1.04e-01	0.16200	-6.22e-02	0.149000	3.24e-01	1.82e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	21	4.46e-01	6.03e-01	0.16100	2.29e-02	0.160000	8.56e-01	2.05e-01
RUNX3 REGULATES NOTCH SIGNALING	13	6.00e-01	7.21e-01	0.16100	9.31e-03	-0.161000	9.54e-01	3.16e-01
SIGNALING BY ERBB4	57	1.05e-01	2.35e-01	0.16000	-3.43e-02	0.156000	6.54e-01	4.13e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	5.20e-01	6.63e-01	0.16000	-7.58e-02	-0.141000	5.78e-01	3.01e-01
SIGNALING BY HEDGEHOG	141	6.61e-03	3.20e-02	0.16000	1.28e-01	0.095500	8.74e-03	5.04e-02
NUCLEOBASE CATABOLISM	31	2.98e-01	4.75e-01	0.15900	-2.53e-02	0.157000	8.08e-01	1.30e-01
RHOBTB1 GTPASE CYCLE	23	4.42e-01	5.99e-01	0.15900	1.01e-01	0.123000	4.00e-01	3.09e-01
TRANSLESION SYNTHESIS BY POLK	17	5.20e-01	6.63e-01	0.15900	-1.17e-02	0.159000	9.33e-01	2.58e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	4.63e-02	1.36e-01	0.15900	-1.17e-01	0.107000	7.73e-02	1.07e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	2.18e-01	3.93e-01	0.15900	7.70e-02	-0.139000	4.12e-01	1.39e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	3.01e-01	4.75e-01	0.15800	1.22e-01	-0.099800	2.46e-01	3.44e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	2.39e-01	4.15e-01	0.15800	9.28e-02	0.127000	3.04e-01	1.58e-01
NEGATIVE REGULATION OF FLT3	14	5.71e-01	7.03e-01	0.15800	1.14e-01	-0.108000	4.59e-01	4.83e-01
SIGNALING BY FGFR	74	7.78e-02	1.91e-01	0.15700	8.24e-02	0.133000	2.21e-01	4.77e-02
INTERLEUKIN 35 SIGNALLING	10	7.06e-01	8.00e-01	0.15600	7.18e-02	0.139000	6.94e-01	4.47e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	5.78e-01	7.07e-01	0.15600	-1.05e-01	0.116000	4.98e-01	4.54e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	1.89e-01	3.63e-01	0.15600	-1.36e-01	0.076500	1.23e-01	3.85e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	6.55e-01	7.58e-01	0.15500	-7.67e-02	0.135000	6.60e-01	4.38e-01
PREGNENOLONE BIOSYNTHESIS	12	6.53e-01	7.57e-01	0.15500	1.53e-01	0.023600	3.58e-01	8.88e-01
ASPARAGINE N LINKED GLYCOSYLATION	283	2.26e-05	3.34e-04	0.15500	-7.62e-02	0.135000	2.76e-02	9.48e-05
REGULATION OF TNFR1 SIGNALING	34	3.13e-01	4.84e-01	0.15500	1.38e-01	0.070300	1.63e-01	4.78e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	13	6.16e-01	7.32e-01	0.15500	3.17e-02	-0.152000	8.43e-01	3.43e-01
MICRORNA MIRNA BIOGENESIS	24	3.96e-01	5.55e-01	0.15500	1.18e-01	-0.101000	3.19e-01	3.92e-01
CA2 PATHWAY	56	1.18e-01	2.56e-01	0.15500	-1.37e-01	0.072800	7.70e-02	3.46e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	3.49e-01	5.19e-01	0.15500	1.46e-01	-0.051700	1.82e-01	6.36e-01
PI3K EVENTS IN ERBB2 SIGNALING	15	5.82e-01	7.07e-01	0.15500	-1.54e-01	0.002700	3.00e-01	9.86e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	3.17e-01	4.88e-01	0.15500	1.50e-01	-0.037600	1.49e-01	7.17e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	138	7.57e-03	3.62e-02	0.15400	8.91e-03	0.154000	8.57e-01	1.78e-03
NEGATIVE REGULATION OF MAPK PATHWAY	43	2.01e-01	3.79e-01	0.15400	-4.79e-02	0.147000	5.87e-01	9.62e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	3.46e-01	5.17e-01	0.15400	7.78e-02	-0.133000	4.76e-01	2.23e-01
STIMULI SENSING CHANNELS	74	7.81e-02	1.91e-01	0.15400	-3.80e-02	-0.149000	5.72e-01	2.64e-02
CARNITINE METABOLISM	14	5.88e-01	7.11e-01	0.15300	-1.11e-01	0.106000	4.71e-01	4.93e-01
ADAPTIVE IMMUNE SYSTEM	594	4.52e-10	1.88e-08	0.15300	-7.47e-02	0.134000	1.96e-03	2.82e-08
SIGNALING BY WNT	266	1.02e-04	1.13e-03	0.15300	3.78e-03	0.153000	9.16e-01	1.84e-05
OLFACTORY SIGNALING PATHWAY	23	4.62e-01	6.17e-01	0.15300	5.45e-02	0.143000	6.51e-01	2.36e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	93	3.17e-02	1.04e-01	0.15300	-7.94e-02	0.130000	1.86e-01	2.98e-02
G2 M DNA DAMAGE CHECKPOINT	65	1.00e-01	2.28e-01	0.15300	-1.52e-01	0.011800	3.38e-02	8.70e-01
PECAM1 INTERACTIONS	12	6.63e-01	7.63e-01	0.15300	2.44e-02	0.151000	8.83e-01	3.67e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	2.64e-01	4.39e-01	0.15200	-9.11e-02	0.121000	3.44e-01	2.07e-01
SIGNALING BY PTK6	50	1.90e-01	3.64e-01	0.15200	4.77e-02	0.144000	5.60e-01	7.79e-02
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	43	2.51e-01	4.25e-01	0.15200	-1.11e-01	-0.103000	2.07e-01	2.43e-01
SYNTHESIS OF PE	12	6.67e-01	7.67e-01	0.15200	-2.62e-02	-0.149000	8.75e-01	3.71e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	73	8.85e-02	2.07e-01	0.15100	-1.46e-01	-0.039100	3.08e-02	5.64e-01
STRIATED MUSCLE CONTRACTION	26	3.85e-01	5.46e-01	0.15100	1.20e-01	-0.092200	2.90e-01	4.16e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	5.10e-01	6.58e-01	0.15100	-1.50e-01	-0.020200	2.47e-01	8.76e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	5.78e-01	7.07e-01	0.15100	1.26e-01	-0.083800	4.00e-01	5.74e-01
SIGNALING BY PDGF	55	1.39e-01	2.84e-01	0.15100	1.39e-01	-0.059900	7.57e-02	4.43e-01
GPCR LIGAND BINDING	259	1.06e-04	1.16e-03	0.15100	-5.51e-02	0.140000	1.28e-01	1.03e-04
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	46	1.92e-01	3.66e-01	0.15100	1.37e-01	-0.061700	1.07e-01	4.69e-01
EGFR DOWNREGULATION	28	3.60e-01	5.24e-01	0.15100	-1.01e-01	0.112000	3.57e-01	3.05e-01
CA DEPENDENT EVENTS	36	2.75e-01	4.52e-01	0.15000	-1.37e-01	0.061700	1.54e-01	5.22e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	3.23e-01	4.96e-01	0.15000	-5.73e-02	-0.139000	5.57e-01	1.55e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	5.97e-01	7.19e-01	0.15000	5.22e-02	0.140000	7.18e-01	3.31e-01
RND1 GTPASE CYCLE	38	3.04e-01	4.78e-01	0.15000	-1.03e-01	-0.109000	2.73e-01	2.46e-01
CLATHRIN MEDIATED ENDOCYTOSIS	133	9.27e-03	4.21e-02	0.14900	-6.95e-02	0.132000	1.67e-01	8.62e-03
SIGNALING BY ERBB2 IN CANCER	25	4.09e-01	5.65e-01	0.14900	-1.01e-01	0.110000	3.83e-01	3.42e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	6.36e-01	7.46e-01	0.14900	3.31e-02	0.145000	8.30e-01	3.47e-01
ASSEMBLY OF THE HIV VIRION	16	6.10e-01	7.29e-01	0.14900	1.00e-01	0.109000	4.87e-01	4.49e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	6.53e-01	7.57e-01	0.14900	-9.41e-02	0.115000	5.73e-01	4.91e-01
DUAL INCISION IN GG NER	40	2.91e-01	4.70e-01	0.14800	9.43e-02	0.115000	3.02e-01	2.10e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	57	1.73e-01	3.41e-01	0.14800	-1.22e-01	-0.084500	1.13e-01	2.70e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	4.39e-01	5.96e-01	0.14800	-4.68e-02	0.140000	6.92e-01	2.34e-01
SIGNALING BY ERBB2	48	2.07e-01	3.85e-01	0.14700	-5.96e-03	0.147000	9.43e-01	7.77e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	4.04e-01	5.60e-01	0.14700	9.82e-02	-0.110000	3.86e-01	3.33e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	25	4.68e-01	6.23e-01	0.14700	-1.09e-01	-0.099300	3.47e-01	3.90e-01
ACYL CHAIN REMODELLING OF PS	14	6.40e-01	7.49e-01	0.14700	-1.45e-01	-0.022500	3.47e-01	8.84e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	1.17e-01	2.54e-01	0.14700	-9.10e-02	0.115000	2.16e-01	1.17e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	5.10e-01	6.58e-01	0.14600	-1.37e-01	0.051200	2.89e-01	6.92e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	6.00e-01	7.21e-01	0.14600	-6.91e-02	0.129000	6.43e-01	3.87e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	3.89e-01	5.49e-01	0.14600	-5.34e-02	-0.136000	6.07e-01	1.91e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	4.87e-01	6.43e-01	0.14500	-2.92e-02	0.143000	8.12e-01	2.47e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	2.96e-01	4.74e-01	0.14500	1.38e-01	-0.045300	1.47e-01	6.34e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	5.89e-01	7.11e-01	0.14400	-1.31e-01	0.061400	3.65e-01	6.70e-01
RNA POLYMERASE I TRANSCRIPTION	67	1.36e-01	2.81e-01	0.14400	1.33e-01	0.055300	5.90e-02	4.34e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	5.05e-01	6.56e-01	0.14400	-3.97e-02	0.139000	7.53e-01	2.71e-01
HS GAG BIOSYNTHESIS	29	3.87e-01	5.49e-01	0.14400	-4.81e-02	0.136000	6.54e-01	2.05e-01
CELL JUNCTION ORGANIZATION	75	8.38e-02	2.00e-01	0.14400	-1.25e-01	0.071300	6.08e-02	2.86e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	43	2.44e-01	4.18e-01	0.14400	-5.85e-02	0.132000	5.07e-01	1.35e-01
LEISHMANIA INFECTION	193	2.40e-03	1.48e-02	0.14300	-2.26e-02	0.141000	5.89e-01	7.11e-04
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	2.08e-01	3.85e-01	0.14300	3.83e-02	0.138000	6.30e-01	8.30e-02
CHOLESTEROL BIOSYNTHESIS	24	4.55e-01	6.11e-01	0.14300	-9.23e-02	0.109000	4.34e-01	3.55e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	84	6.39e-02	1.69e-01	0.14300	1.06e-01	-0.095500	9.25e-02	1.30e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	62	1.58e-01	3.17e-01	0.14300	1.40e-01	0.028200	5.69e-02	7.01e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	6.76e-01	7.74e-01	0.14200	-1.33e-02	-0.142000	9.34e-01	3.77e-01
RHOV GTPASE CYCLE	32	4.02e-01	5.59e-01	0.14200	-6.95e-02	-0.124000	4.96e-01	2.26e-01
SURFACTANT METABOLISM	16	6.23e-01	7.36e-01	0.14200	2.52e-02	0.140000	8.61e-01	3.34e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	4.14e-01	5.70e-01	0.14100	-1.07e-02	0.141000	9.21e-01	1.89e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	90	5.82e-02	1.59e-01	0.14100	-6.26e-02	0.127000	3.05e-01	3.78e-02
RNA POLYMERASE III TRANSCRIPTION	41	2.71e-01	4.47e-01	0.14100	8.28e-02	-0.114000	3.59e-01	2.06e-01
POTENTIAL THERAPEUTICS FOR SARS	76	1.23e-01	2.60e-01	0.14100	1.00e-01	0.098500	1.30e-01	1.38e-01
DNA STRAND ELONGATION	32	3.73e-01	5.36e-01	0.14100	-3.85e-02	0.135000	7.06e-01	1.86e-01
ERBB2 REGULATES CELL MOTILITY	14	6.53e-01	7.57e-01	0.14100	-1.38e-01	0.024300	3.70e-01	8.75e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	17	6.13e-01	7.30e-01	0.14000	-3.12e-02	-0.137000	8.24e-01	3.28e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	32	4.00e-01	5.58e-01	0.14000	1.36e-01	0.033500	1.82e-01	7.43e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	24	4.90e-01	6.46e-01	0.14000	-4.59e-03	0.140000	9.69e-01	2.35e-01
HEMOSTASIS	471	1.94e-06	4.53e-05	0.14000	2.94e-02	0.137000	2.77e-01	3.87e-07
CELL CYCLE CHECKPOINTS	241	7.13e-04	5.44e-03	0.14000	-3.47e-02	0.136000	3.55e-01	2.95e-04
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	45	2.92e-01	4.71e-01	0.14000	1.06e-01	0.091500	2.20e-01	2.89e-01
RHOB GTPASE CYCLE	67	1.31e-01	2.75e-01	0.14000	1.35e-01	-0.035400	5.58e-02	6.17e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	4.31e-01	5.88e-01	0.13900	-7.08e-03	-0.139000	9.47e-01	1.94e-01
ZINC TRANSPORTERS	15	6.26e-01	7.38e-01	0.13900	-8.66e-02	0.109000	5.61e-01	4.64e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	15	6.36e-01	7.46e-01	0.13900	-1.35e-01	0.033800	3.65e-01	8.21e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	4.90e-01	6.46e-01	0.13900	7.79e-02	-0.115000	5.18e-01	3.38e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	6.26e-01	7.38e-01	0.13900	-1.39e-01	0.006710	3.37e-01	9.63e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	62	1.86e-01	3.59e-01	0.13900	-1.20e-01	-0.069700	1.02e-01	3.43e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	2.21e-01	3.96e-01	0.13900	-9.21e-02	0.104000	2.65e-01	2.10e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	6.46e-01	7.53e-01	0.13700	1.35e-01	-0.023300	3.64e-01	8.76e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	69	1.31e-01	2.75e-01	0.13700	-4.91e-02	0.128000	4.81e-01	6.65e-02
DEADENYLATION OF MRNA	25	4.97e-01	6.50e-01	0.13700	-1.37e-01	-0.004670	2.37e-01	9.68e-01
HCMV EARLY EVENTS	79	9.39e-02	2.16e-01	0.13700	1.07e-01	-0.085300	1.01e-01	1.90e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	5.91e-01	7.13e-01	0.13700	7.26e-02	0.116000	5.74e-01	3.70e-01
RHO GTPASE EFFECTORS	247	1.50e-03	9.98e-03	0.13600	5.10e-02	0.127000	1.69e-01	6.24e-04
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	83	9.27e-02	2.15e-01	0.13600	-2.60e-02	0.134000	6.83e-01	3.50e-02
RIPK1 MEDIATED REGULATED NECROSIS	25	5.01e-01	6.53e-01	0.13600	1.34e-02	0.136000	9.08e-01	2.40e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	63	1.53e-01	3.08e-01	0.13600	-1.00e-01	0.092700	1.70e-01	2.04e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	5.80e-01	7.07e-01	0.13600	-7.95e-02	-0.110000	5.28e-01	3.82e-01
SIGNALING BY EGFR	47	2.77e-01	4.54e-01	0.13600	1.58e-02	0.135000	8.52e-01	1.10e-01
DNA DAMAGE RECOGNITION IN GG NER	38	3.55e-01	5.23e-01	0.13500	1.19e-02	0.135000	8.99e-01	1.50e-01
HIV ELONGATION ARREST AND RECOVERY	32	4.20e-01	5.76e-01	0.13500	1.35e-01	0.012000	1.88e-01	9.07e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	8.03e-02	1.94e-01	0.13500	-6.74e-02	0.117000	2.77e-01	5.94e-02
SIGNALING BY LEPTIN	10	7.50e-01	8.37e-01	0.13500	5.02e-02	-0.125000	7.83e-01	4.93e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	49	2.58e-01	4.34e-01	0.13400	-1.33e-01	0.017100	1.06e-01	8.36e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	1.95e-01	3.68e-01	0.13400	-1.19e-02	-0.134000	8.73e-01	7.06e-02
DEFECTS IN COBALAMIN B12 METABOLISM	12	7.32e-01	8.24e-01	0.13400	3.37e-02	0.129000	8.40e-01	4.38e-01
VITAMIN B5 PANTOTHENATE METABOLISM	14	6.84e-01	7.81e-01	0.13400	-8.86e-03	0.133000	9.54e-01	3.88e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	7.63e-01	8.47e-01	0.13300	1.33e-01	-0.006490	4.66e-01	9.72e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	3.36e-01	5.10e-01	0.13300	9.00e-02	0.098000	3.02e-01	2.61e-01
RECYCLING PATHWAY OF L1	40	3.73e-01	5.36e-01	0.13300	8.38e-02	0.103000	3.59e-01	2.61e-01
SIGNALING BY NTRK2 TRKB	24	5.09e-01	6.58e-01	0.13300	-1.13e-01	0.068900	3.36e-01	5.59e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	31	4.60e-01	6.17e-01	0.13200	-4.63e-02	-0.124000	6.55e-01	2.33e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	1.21e-01	2.58e-01	0.13200	-4.35e-02	-0.124000	4.89e-01	4.80e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	4.25e-01	5.82e-01	0.13200	1.29e-01	-0.024800	2.06e-01	8.08e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	25	5.46e-01	6.82e-01	0.13100	7.71e-02	0.106000	5.05e-01	3.58e-01
RND2 GTPASE CYCLE	38	3.73e-01	5.36e-01	0.13100	1.12e-02	-0.130000	9.05e-01	1.65e-01
NERVOUS SYSTEM DEVELOPMENT	546	3.37e-06	7.14e-05	0.13000	9.14e-02	0.093100	2.76e-04	2.12e-04
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	35	3.88e-01	5.49e-01	0.13000	7.78e-02	-0.104000	4.26e-01	2.87e-01
RESOLUTION OF ABASIC SITES AP SITES	37	3.86e-01	5.48e-01	0.12900	1.28e-01	-0.018800	1.78e-01	8.43e-01
SIGNALING BY SCF KIT	41	3.54e-01	5.23e-01	0.12900	-1.29e-01	0.011600	1.55e-01	8.98e-01
INTERLEUKIN 6 FAMILY SIGNALING	18	6.35e-01	7.46e-01	0.12900	1.28e-01	-0.009540	3.46e-01	9.44e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	37	4.13e-01	5.70e-01	0.12900	4.10e-02	0.122000	6.66e-01	1.99e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	83	1.39e-01	2.86e-01	0.12900	-1.21e-01	-0.044400	5.71e-02	4.85e-01
DEUBIQUITINATION	240	2.65e-03	1.59e-02	0.12800	-1.22e-02	0.128000	7.46e-01	6.78e-04
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	38	4.17e-01	5.73e-01	0.12800	6.75e-02	0.109000	4.72e-01	2.47e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	114	6.05e-02	1.63e-01	0.12800	-7.47e-03	0.127000	8.90e-01	1.88e-02
RESOLUTION OF SISTER CHROMATID COHESION	100	1.01e-01	2.28e-01	0.12800	6.24e-02	0.111000	2.81e-01	5.45e-02
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	6.91e-01	7.87e-01	0.12800	1.27e-01	-0.006180	3.93e-01	9.67e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	31	4.60e-01	6.17e-01	0.12700	-2.53e-02	0.125000	8.08e-01	2.29e-01
SIGNALING BY NUCLEAR RECEPTORS	219	4.45e-03	2.39e-02	0.12600	-4.27e-02	0.119000	2.77e-01	2.51e-03
NETRIN 1 SIGNALING	49	3.37e-01	5.12e-01	0.12600	-9.01e-02	-0.088000	2.76e-01	2.87e-01
MET PROMOTES CELL MOTILITY	39	3.96e-01	5.55e-01	0.12600	1.26e-01	0.003570	1.74e-01	9.69e-01
PHOSPHORYLATION OF THE APC C	17	6.56e-01	7.58e-01	0.12600	-1.18e-01	0.042700	3.99e-01	7.60e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	3.59e-01	5.24e-01	0.12600	5.51e-02	-0.113000	5.42e-01	2.11e-01
SYNTHESIS OF PA	29	5.24e-01	6.65e-01	0.12500	5.73e-02	0.111000	5.93e-01	2.99e-01
AMINO ACIDS REGULATE MTORC1	51	3.01e-01	4.75e-01	0.12500	8.97e-04	0.125000	9.91e-01	1.22e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	7.85e-01	8.62e-01	0.12500	-1.23e-01	0.021600	4.99e-01	9.06e-01
PEPTIDE LIGAND BINDING RECEPTORS	101	8.79e-02	2.06e-01	0.12500	-2.42e-02	0.123000	6.75e-01	3.31e-02
NEPHRIN FAMILY INTERACTIONS	22	6.12e-01	7.29e-01	0.12500	1.18e-01	0.039600	3.38e-01	7.48e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	21	5.96e-01	7.19e-01	0.12400	-6.31e-02	0.107000	6.17e-01	3.96e-01
SIGNAL TRANSDUCTION BY L1	21	6.21e-01	7.34e-01	0.12400	1.97e-02	0.123000	8.76e-01	3.31e-01
GLYCOSAMINOGLYCAN METABOLISM	114	6.21e-02	1.66e-01	0.12400	-5.94e-02	0.109000	2.73e-01	4.48e-02
POST TRANSLATIONAL PROTEIN MODIFICATION	1205	9.82e-13	4.98e-11	0.12400	-8.16e-02	0.093100	2.28e-06	6.88e-08
INTRA GOLGI TRAFFIC	43	3.67e-01	5.32e-01	0.12300	-1.22e-01	0.015600	1.65e-01	8.59e-01
G ALPHA Q SIGNALLING EVENTS	154	3.01e-02	1.01e-01	0.12300	-9.54e-04	0.123000	9.84e-01	8.32e-03
INTRINSIC PATHWAY FOR APOPTOSIS	50	2.96e-01	4.74e-01	0.12300	-7.86e-02	0.094800	3.36e-01	2.46e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	536	4.38e-06	8.96e-05	0.12300	-4.13e-02	0.116000	1.03e-01	4.94e-06
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	175	1.67e-02	6.61e-02	0.12300	-1.18e-01	0.035500	7.35e-03	4.18e-01
RNA POLYMERASE III CHAIN ELONGATION	18	6.49e-01	7.55e-01	0.12300	1.05e-01	-0.063900	4.43e-01	6.39e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	7.93e-01	8.66e-01	0.12200	5.81e-02	0.107000	7.38e-01	5.38e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	7.78e-01	8.58e-01	0.12200	7.13e-02	0.098900	6.69e-01	5.53e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	281	1.42e-03	9.63e-03	0.12200	1.06e-01	-0.060900	2.38e-03	7.94e-02
TRAFFICKING OF AMPA RECEPTORS	31	4.94e-01	6.47e-01	0.12200	1.83e-02	-0.120000	8.60e-01	2.46e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	4.24e-01	5.81e-01	0.12100	1.10e-01	0.049700	2.21e-01	5.82e-01
METABOLISM OF LIPIDS	608	1.98e-06	4.53e-05	0.12100	-1.52e-02	0.120000	5.23e-01	4.95e-07
SIGNALLING TO ERKS	34	4.51e-01	6.07e-01	0.12100	-9.33e-02	0.076700	3.47e-01	4.39e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	71	2.08e-01	3.85e-01	0.12100	-1.20e-01	0.011500	8.05e-02	8.67e-01
ESR MEDIATED SIGNALING	163	2.46e-02	8.58e-02	0.12000	-6.44e-02	0.101000	1.57e-01	2.64e-02
RHOJ GTPASE CYCLE	54	3.24e-01	4.96e-01	0.11900	1.65e-02	0.118000	8.33e-01	1.34e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	5.68e-01	7.02e-01	0.11900	4.71e-02	0.109000	6.66e-01	3.17e-01
RAC1 GTPASE CYCLE	177	2.69e-02	9.27e-02	0.11900	1.16e-01	0.028000	8.04e-03	5.22e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	6.42e-01	7.49e-01	0.11900	-1.19e-01	-0.001360	3.47e-01	9.91e-01
SIGNALING BY NTRKS	131	5.32e-02	1.50e-01	0.11800	-8.38e-02	0.083500	9.80e-02	9.91e-02
MAPK FAMILY SIGNALING CASCADES	287	3.42e-03	1.92e-02	0.11800	3.68e-02	0.112000	2.85e-01	1.10e-03
FORMATION OF RNA POL II ELONGATION COMPLEX	57	3.03e-01	4.77e-01	0.11700	1.17e-01	-0.009630	1.26e-01	9.00e-01
RORA ACTIVATES GENE EXPRESSION	18	6.88e-01	7.84e-01	0.11700	1.42e-03	-0.117000	9.92e-01	3.88e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	6.16e-01	7.32e-01	0.11700	1.01e-01	0.059900	3.84e-01	6.04e-01
TBC RABGAPS	43	4.01e-01	5.58e-01	0.11700	-2.67e-02	0.114000	7.62e-01	1.96e-01
INTERLEUKIN 15 SIGNALING	12	7.86e-01	8.62e-01	0.11600	-1.15e-01	-0.015900	4.89e-01	9.24e-01
METABOLISM OF FOLATE AND PTERINES	15	7.47e-01	8.36e-01	0.11600	1.08e-01	0.043900	4.70e-01	7.69e-01
PTEN REGULATION	134	8.11e-02	1.95e-01	0.11600	7.97e-02	0.084400	1.12e-01	9.19e-02
EPH EPHRIN SIGNALING	90	1.52e-01	3.08e-01	0.11600	-3.37e-02	0.111000	5.80e-01	6.93e-02
INTEGRATION OF ENERGY METABOLISM	98	1.50e-01	3.03e-01	0.11500	2.30e-02	0.113000	6.94e-01	5.33e-02
SIGNALING BY NODAL	15	7.43e-01	8.32e-01	0.11500	8.23e-03	0.115000	9.56e-01	4.41e-01
TNF SIGNALING	43	4.51e-01	6.07e-01	0.11500	8.34e-02	0.079400	3.44e-01	3.68e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	3.29e-01	5.03e-01	0.11500	-5.36e-02	0.102000	5.00e-01	2.01e-01
FANCONI ANEMIA PATHWAY	36	4.74e-01	6.29e-01	0.11400	4.84e-02	-0.104000	6.15e-01	2.82e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	31	5.32e-01	6.70e-01	0.11400	-3.08e-02	0.110000	7.66e-01	2.89e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	169	3.09e-02	1.03e-01	0.11400	-7.02e-02	0.089400	1.16e-01	4.52e-02
TRANSPORT OF SMALL MOLECULES	565	1.53e-05	2.47e-04	0.11300	-4.12e-02	0.106000	9.53e-02	1.90e-05
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	2.85e-01	4.63e-01	0.11300	-2.78e-02	0.110000	7.03e-01	1.31e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	7.92e-01	8.66e-01	0.11300	7.74e-02	0.082300	6.29e-01	6.07e-01
SLC TRANSPORTER DISORDERS	69	2.51e-01	4.25e-01	0.11300	-1.05e-01	0.041200	1.31e-01	5.55e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	1.59e-01	3.18e-01	0.11300	-3.38e-02	0.107000	5.74e-01	7.35e-02
CHONDROITIN SULFATE BIOSYNTHESIS	19	6.80e-01	7.76e-01	0.11300	-6.52e-02	0.091700	6.23e-01	4.89e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	77	2.29e-01	4.04e-01	0.11200	-6.25e-03	0.112000	9.24e-01	8.86e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	10	8.34e-01	8.99e-01	0.11200	3.89e-02	0.105000	8.31e-01	5.64e-01
G PROTEIN MEDIATED EVENTS	52	3.53e-01	5.23e-01	0.11200	-6.21e-02	0.093100	4.39e-01	2.45e-01
SEMAPHORIN INTERACTIONS	64	2.78e-01	4.55e-01	0.11200	9.38e-02	-0.061100	1.95e-01	3.98e-01
RETROGRADE NEUROTROPHIN SIGNALLING	14	7.75e-01	8.55e-01	0.11200	2.84e-02	0.108000	8.54e-01	4.83e-01
NUCLEAR ENVELOPE NE REASSEMBLY	63	3.33e-01	5.06e-01	0.11200	7.48e-02	0.083000	3.05e-01	2.55e-01
TRNA PROCESSING	105	1.31e-01	2.75e-01	0.11200	3.27e-02	-0.107000	5.62e-01	5.92e-02
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	5.33e-01	6.70e-01	0.11100	-2.98e-03	-0.111000	9.76e-01	2.63e-01
TELOMERE C STRAND SYNTHESIS INITIATION	13	7.79e-01	8.58e-01	0.11100	1.08e-01	-0.027100	5.01e-01	8.66e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	18	7.37e-01	8.27e-01	0.11000	6.29e-02	0.089900	6.44e-01	5.09e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	1.80e-01	3.52e-01	0.10900	-4.32e-02	0.100000	4.77e-01	9.79e-02
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	8.36e-01	9.00e-01	0.10900	1.70e-03	0.109000	9.93e-01	5.50e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	4.62e-01	6.17e-01	0.10900	-1.04e-01	-0.033500	2.29e-01	6.98e-01
BASE EXCISION REPAIR	56	3.60e-01	5.24e-01	0.10900	1.07e-01	-0.020500	1.66e-01	7.91e-01
SENSORY PROCESSING OF SOUND	61	3.48e-01	5.19e-01	0.10900	1.07e-01	0.021200	1.50e-01	7.75e-01
RHOU GTPASE CYCLE	33	5.70e-01	7.02e-01	0.10800	-1.05e-01	-0.026800	2.97e-01	7.90e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	5.84e-01	7.08e-01	0.10800	-8.05e-02	-0.071900	4.23e-01	4.75e-01
NICOTINAMIDE SALVAGING	15	7.57e-01	8.41e-01	0.10800	9.13e-02	-0.057400	5.41e-01	7.01e-01
POTASSIUM CHANNELS	90	2.18e-01	3.93e-01	0.10800	-1.06e-01	-0.021900	8.37e-02	7.20e-01
RAC2 GTPASE CYCLE	86	2.47e-01	4.22e-01	0.10700	4.55e-02	0.096800	4.66e-01	1.21e-01
GLUCOSE METABOLISM	80	2.62e-01	4.37e-01	0.10700	1.35e-02	0.106000	8.35e-01	1.02e-01
MITOTIC PROPHASE	92	1.96e-01	3.70e-01	0.10500	-8.97e-02	0.055400	1.37e-01	3.59e-01
NUCLEOTIDE EXCISION REPAIR	109	1.54e-01	3.10e-01	0.10500	-2.74e-02	0.102000	6.21e-01	6.72e-02
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	42	5.19e-01	6.63e-01	0.10500	-4.44e-02	-0.094800	6.18e-01	2.88e-01
DUAL INCISION IN TC NER	64	3.48e-01	5.19e-01	0.10400	-5.09e-03	0.104000	9.44e-01	1.49e-01
INTERLEUKIN 2 FAMILY SIGNALING	33	6.09e-01	7.29e-01	0.10400	7.00e-02	0.076300	4.86e-01	4.48e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	92	2.11e-01	3.85e-01	0.10400	-4.45e-02	0.093500	4.61e-01	1.21e-01
MITOTIC G2 G2 M PHASES	184	6.31e-02	1.68e-01	0.10300	9.02e-02	0.050700	3.50e-02	2.36e-01
RHO GTPASES ACTIVATE FORMINS	118	1.68e-01	3.32e-01	0.10300	4.19e-02	0.094400	4.32e-01	7.69e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS	20	7.25e-01	8.18e-01	0.10300	-1.03e-01	0.002700	4.25e-01	9.83e-01
MEIOTIC SYNAPSIS	39	5.25e-01	6.66e-01	0.10200	9.62e-02	-0.035300	2.98e-01	7.03e-01
RUNX2 REGULATES BONE DEVELOPMENT	29	6.17e-01	7.32e-01	0.10200	-7.04e-02	0.073500	5.12e-01	4.94e-01
FLT3 SIGNALING	36	5.69e-01	7.02e-01	0.10100	-1.01e-01	0.008880	2.94e-01	9.27e-01
RAB REGULATION OF TRAFFICKING	118	1.48e-01	3.01e-01	0.10100	-4.09e-02	0.092800	4.43e-01	8.21e-02
REGULATION OF PTEN GENE TRANSCRIPTION	59	3.81e-01	5.42e-01	0.10100	7.85e-02	-0.063600	2.97e-01	3.99e-01
HIV TRANSCRIPTION INITIATION	45	4.93e-01	6.47e-01	0.10100	-1.93e-02	0.099100	8.23e-01	2.50e-01
CELL CELL COMMUNICATION	107	1.81e-01	3.53e-01	0.09990	-7.82e-02	0.062300	1.63e-01	2.66e-01
NUCLEAR IMPORT OF REV PROTEIN	32	6.34e-01	7.46e-01	0.09990	-4.22e-02	-0.090600	6.80e-01	3.75e-01
SIGNALING BY GPCR	476	6.47e-04	4.99e-03	0.09990	-4.44e-02	0.089500	9.79e-02	8.60e-04
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	74	3.09e-01	4.81e-01	0.09970	8.29e-02	-0.055300	2.18e-01	4.11e-01
MITOTIC SPINDLE CHECKPOINT	96	2.34e-01	4.09e-01	0.09960	-1.33e-02	0.098700	8.22e-01	9.50e-02
MEIOTIC RECOMBINATION	38	5.62e-01	6.96e-01	0.09900	-9.68e-02	0.020900	3.02e-01	8.24e-01
EFFECTS OF PIP2 HYDROLYSIS	27	6.62e-01	7.62e-01	0.09840	3.76e-02	-0.091000	7.35e-01	4.13e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	7.15e-01	8.10e-01	0.09830	-1.28e-03	0.098300	9.92e-01	4.14e-01
REGULATION OF INSULIN SECRETION	71	3.55e-01	5.23e-01	0.09820	-6.27e-03	0.098000	9.27e-01	1.54e-01
METABOLISM OF STEROIDS	111	2.10e-01	3.85e-01	0.09760	8.73e-03	0.097200	8.74e-01	7.71e-02
NEUROTRANSMITTER RELEASE CYCLE	48	5.19e-01	6.63e-01	0.09720	2.79e-02	0.093200	7.38e-01	2.64e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	6.32e-01	7.44e-01	0.09710	9.60e-02	0.014700	3.40e-01	8.84e-01
INTERLEUKIN 17 SIGNALING	66	3.78e-01	5.40e-01	0.09700	-9.12e-02	0.032900	2.00e-01	6.44e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	8.64e-01	9.15e-01	0.09630	-3.98e-02	-0.087700	8.19e-01	6.14e-01
INOSITOL PHOSPHATE METABOLISM	47	5.45e-01	6.82e-01	0.09610	6.27e-02	0.072800	4.57e-01	3.88e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	8.41e-01	9.02e-01	0.09610	3.22e-02	0.090500	8.41e-01	5.72e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	8.04e-01	8.74e-01	0.09600	8.83e-02	-0.037600	5.54e-01	8.01e-01
DEVELOPMENTAL BIOLOGY	809	5.10e-05	6.33e-04	0.09570	6.94e-02	0.065900	8.60e-04	1.54e-03
MEMBRANE TRAFFICKING	579	3.49e-04	3.04e-03	0.09490	-3.63e-02	0.087700	1.37e-01	3.31e-04
DISEASES OF METABOLISM	198	8.43e-02	2.01e-01	0.09480	7.69e-02	0.055300	6.23e-02	1.80e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	8.29e-01	8.95e-01	0.09440	5.90e-02	0.073700	6.93e-01	6.21e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	3.60e-01	5.24e-01	0.09430	-8.73e-02	0.035600	1.97e-01	5.99e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	5.88e-01	7.11e-01	0.09360	1.20e-02	0.092800	8.94e-01	3.04e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	8.05e-01	8.74e-01	0.09340	2.32e-02	-0.090500	8.72e-01	5.31e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	365	9.04e-03	4.12e-02	0.09320	-5.08e-03	0.093000	8.68e-01	2.33e-03
SIGNALING BY NOTCH2	33	6.70e-01	7.69e-01	0.09310	-6.89e-02	-0.062600	4.93e-01	5.34e-01
MYOGENESIS	25	7.38e-01	8.27e-01	0.09270	-4.59e-02	-0.080600	6.91e-01	4.86e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	235	4.13e-02	1.25e-01	0.09260	-7.73e-02	0.051000	4.16e-02	1.79e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	66	4.18e-01	5.74e-01	0.09260	1.90e-02	-0.090600	7.89e-01	2.03e-01
NUCLEOTIDE SALVAGE	21	7.74e-01	8.55e-01	0.09170	-8.76e-02	-0.027200	4.87e-01	8.29e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	6.45e-01	7.52e-01	0.09160	-7.85e-02	-0.047200	4.09e-01	6.19e-01
SIGNALLING TO RAS	20	7.64e-01	8.47e-01	0.09140	6.64e-02	-0.062900	6.07e-01	6.26e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	4.91e-01	6.46e-01	0.09090	4.74e-02	-0.077600	5.47e-01	3.24e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	7.49e-01	8.37e-01	0.09000	-2.00e-02	0.087700	8.68e-01	4.67e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	103	2.65e-01	4.40e-01	0.08990	7.30e-02	-0.052500	2.01e-01	3.58e-01
APOPTOTIC EXECUTION PHASE	45	5.63e-01	6.97e-01	0.08970	-4.12e-02	0.079700	6.33e-01	3.55e-01
GENE SILENCING BY RNA	83	3.79e-01	5.40e-01	0.08940	-1.47e-02	-0.088100	8.17e-01	1.65e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	7.27e-01	8.18e-01	0.08930	3.32e-02	0.082900	7.61e-01	4.48e-01
OXIDATIVE STRESS INDUCED SENESCENCE	78	3.79e-01	5.40e-01	0.08900	3.33e-02	-0.082500	6.11e-01	2.08e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	6.60e-01	7.62e-01	0.08860	-8.75e-02	-0.014500	3.64e-01	8.81e-01
MITOCHONDRIAL BIOGENESIS	92	3.68e-01	5.33e-01	0.08820	6.35e-02	0.061200	2.93e-01	3.11e-01
CARDIAC CONDUCTION	108	3.06e-01	4.79e-01	0.08820	-7.79e-02	-0.041200	1.62e-01	4.60e-01
HS GAG DEGRADATION	20	7.96e-01	8.69e-01	0.08780	-1.13e-02	-0.087000	9.30e-01	5.01e-01
HIV LIFE CYCLE	143	2.08e-01	3.85e-01	0.08760	2.85e-02	0.082800	5.56e-01	8.77e-02
REGULATION OF LIPID METABOLISM BY PPARALPHA	107	3.15e-01	4.86e-01	0.08760	-4.28e-02	-0.076400	4.45e-01	1.73e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	12	8.74e-01	9.23e-01	0.08710	-8.62e-02	-0.012300	6.05e-01	9.41e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	49	5.82e-01	7.07e-01	0.08650	1.12e-02	0.085800	8.92e-01	2.99e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	463	7.14e-03	3.44e-02	0.08650	1.68e-02	0.084800	5.36e-01	1.82e-03
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	7.86e-01	8.62e-01	0.08650	5.96e-02	-0.062700	6.45e-01	6.28e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	47	6.12e-01	7.29e-01	0.08630	6.95e-02	0.051300	4.10e-01	5.43e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	35	6.94e-01	7.89e-01	0.08610	4.65e-02	0.072500	6.34e-01	4.58e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	7.96e-01	8.69e-01	0.08610	8.51e-02	-0.013400	5.10e-01	9.17e-01
HATS ACETYLATE HISTONES	91	3.81e-01	5.42e-01	0.08600	-2.86e-02	-0.081100	6.38e-01	1.81e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	5.73e-01	7.03e-01	0.08570	-3.49e-02	0.078300	6.76e-01	3.48e-01
VESICLE MEDIATED TRANSPORT	607	1.23e-03	8.65e-03	0.08560	-2.37e-02	0.082300	3.21e-01	5.67e-04
TRANSCRIPTION OF THE HIV GENOME	67	5.09e-01	6.58e-01	0.08480	5.03e-02	0.068300	4.77e-01	3.34e-01
NICOTINATE METABOLISM	24	7.59e-01	8.43e-01	0.08470	7.15e-02	-0.045400	5.44e-01	7.00e-01
METABOLISM OF VITAMINS AND COFACTORS	148	2.22e-01	3.98e-01	0.08440	3.01e-02	0.078900	5.28e-01	9.79e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	8.92e-01	9.32e-01	0.08430	5.38e-02	-0.064900	7.68e-01	7.22e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	5.28e-01	6.67e-01	0.08380	1.74e-02	-0.081900	8.17e-01	2.77e-01
THE PHOTOTRANSDUCTION CASCADE	20	7.98e-01	8.70e-01	0.08370	-6.13e-02	0.057000	6.35e-01	6.59e-01
DNA REPAIR	291	5.95e-02	1.61e-01	0.08370	-4.80e-02	-0.068500	1.59e-01	4.47e-02
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	628	2.85e-03	1.70e-02	0.08310	6.04e-02	0.057100	1.01e-02	1.51e-02
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	61	5.09e-01	6.58e-01	0.08310	-6.41e-02	0.052900	3.87e-01	4.75e-01
CONDENSATION OF PROPHASE CHROMOSOMES	27	7.52e-01	8.38e-01	0.08300	-1.01e-02	0.082400	9.28e-01	4.59e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	95	3.57e-01	5.23e-01	0.08260	7.05e-02	-0.042900	2.35e-01	4.70e-01
M PHASE	336	4.19e-02	1.26e-01	0.08200	3.15e-02	0.075700	3.23e-01	1.73e-02
PI3K AKT SIGNALING IN CANCER	88	3.94e-01	5.54e-01	0.08130	-6.26e-02	0.051800	3.10e-01	4.01e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	65	5.47e-01	6.82e-01	0.08130	6.87e-02	0.043300	3.38e-01	5.46e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	9.03e-01	9.38e-01	0.08120	6.34e-02	0.050800	7.16e-01	7.70e-01
PRE NOTCH EXPRESSION AND PROCESSING	63	5.29e-01	6.68e-01	0.08120	1.19e-02	-0.080300	8.70e-01	2.70e-01
VISUAL PHOTOTRANSDUCTION	58	5.55e-01	6.90e-01	0.08070	-7.69e-02	0.024500	3.11e-01	7.47e-01
MTOR SIGNALLING	40	6.67e-01	7.67e-01	0.08070	-2.01e-02	0.078100	8.26e-01	3.93e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	8.64e-01	9.15e-01	0.08060	4.53e-02	0.066700	7.54e-01	6.44e-01
NUCLEAR SIGNALING BY ERBB4	31	7.54e-01	8.39e-01	0.08050	4.95e-02	0.063500	6.33e-01	5.41e-01
DISEASES OF PROGRAMMED CELL DEATH	54	6.18e-01	7.32e-01	0.07980	5.62e-02	0.056600	4.75e-01	4.72e-01
RNA POLYMERASE I PROMOTER ESCAPE	47	6.61e-01	7.62e-01	0.07920	4.56e-02	0.064800	5.89e-01	4.42e-01
GAB1 SIGNALOSOME	14	8.83e-01	9.26e-01	0.07870	2.71e-02	0.073800	8.60e-01	6.32e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	8.00e-01	8.70e-01	0.07840	3.26e-02	-0.071300	7.87e-01	5.54e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	107	4.01e-01	5.58e-01	0.07790	3.96e-02	0.067100	4.79e-01	2.31e-01
NOD1 2 SIGNALING PATHWAY	35	7.44e-01	8.32e-01	0.07780	5.60e-02	0.054000	5.67e-01	5.80e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	281	8.40e-02	2.00e-01	0.07760	7.35e-03	0.077300	8.32e-01	2.61e-02
INTERLEUKIN 20 FAMILY SIGNALING	14	8.82e-01	9.26e-01	0.07760	7.75e-02	0.004370	6.16e-01	9.77e-01
NUCLEAR ENVELOPE BREAKDOWN	47	6.74e-01	7.71e-01	0.07740	-4.67e-02	-0.061700	5.79e-01	4.64e-01
G ALPHA 12 13 SIGNALLING EVENTS	75	5.24e-01	6.65e-01	0.07700	7.48e-02	0.018300	2.63e-01	7.84e-01
NEUREXINS AND NEUROLIGINS	54	6.01e-01	7.22e-01	0.07690	3.94e-02	-0.066100	6.17e-01	4.01e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	8.52e-01	9.08e-01	0.07670	-2.69e-03	0.076700	9.84e-01	5.73e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	8.52e-01	9.08e-01	0.07570	1.43e-02	0.074300	9.14e-01	5.75e-01
CELL CYCLE MITOTIC	470	2.23e-02	7.97e-02	0.07530	1.39e-02	0.074000	6.08e-01	6.15e-03
MITOTIC PROMETAPHASE	175	2.18e-01	3.93e-01	0.07510	7.25e-02	-0.019600	9.83e-02	6.54e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	8.78e-01	9.25e-01	0.07510	7.45e-02	-0.009980	6.18e-01	9.47e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	176	2.48e-01	4.22e-01	0.07480	6.87e-02	0.029700	1.16e-01	4.97e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	9.02e-01	9.37e-01	0.07480	-3.72e-02	-0.064900	8.17e-01	6.85e-01
DAG AND IP3 SIGNALING	40	7.20e-01	8.13e-01	0.07460	-7.41e-02	-0.008280	4.18e-01	9.28e-01
VLDLR INTERNALISATION AND DEGRADATION	12	9.00e-01	9.36e-01	0.07370	-5.41e-02	0.050100	7.46e-01	7.64e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	8.32e-01	8.98e-01	0.07310	-2.02e-02	0.070200	8.70e-01	5.68e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	6.61e-01	7.62e-01	0.07300	-3.64e-02	-0.063300	6.41e-01	4.17e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	9.11e-01	9.43e-01	0.07280	-5.86e-02	0.043200	7.36e-01	8.04e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	8.46e-01	9.04e-01	0.07200	-4.74e-02	0.054200	7.14e-01	6.75e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	141	3.13e-01	4.84e-01	0.07200	-4.03e-02	0.059600	4.09e-01	2.22e-01
OTHER INTERLEUKIN SIGNALING	20	8.65e-01	9.15e-01	0.07120	6.59e-02	0.027000	6.10e-01	8.34e-01
NEURONAL SYSTEM	363	6.84e-02	1.75e-01	0.07110	-7.10e-02	-0.003700	2.06e-02	9.04e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	7.85e-01	8.62e-01	0.07100	-1.60e-02	0.069200	8.78e-01	5.05e-01
CELLULAR SENESCENCE	140	3.42e-01	5.17e-01	0.07080	1.07e-02	-0.070000	8.26e-01	1.53e-01
VIRAL MESSENGER RNA SYNTHESIS	42	7.34e-01	8.25e-01	0.07080	-1.18e-02	-0.069800	8.95e-01	4.34e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	117	3.93e-01	5.52e-01	0.07080	5.70e-02	-0.041900	2.87e-01	4.34e-01
RHO GTPASE CYCLE	427	5.31e-02	1.50e-01	0.07060	6.07e-02	0.036000	3.19e-02	2.03e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	76	5.57e-01	6.92e-01	0.07060	-1.55e-02	0.068900	8.15e-01	3.00e-01
G1 S SPECIFIC TRANSCRIPTION	26	8.16e-01	8.84e-01	0.07050	-6.62e-02	0.024200	5.59e-01	8.31e-01
HOMOLOGY DIRECTED REPAIR	107	4.76e-01	6.31e-01	0.07050	-5.48e-02	-0.044300	3.28e-01	4.29e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	22	8.45e-01	9.04e-01	0.07020	1.78e-02	-0.067900	8.85e-01	5.81e-01
HCMV INFECTION	102	4.61e-01	6.17e-01	0.07000	6.76e-02	-0.018100	2.38e-01	7.52e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	8.55e-01	9.09e-01	0.06950	5.91e-02	0.036600	6.24e-01	7.61e-01
ION TRANSPORT BY P TYPE ATPASES	47	7.20e-01	8.13e-01	0.06930	-1.70e-02	-0.067200	8.40e-01	4.26e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	8.99e-01	9.36e-01	0.06930	-6.48e-02	0.024600	6.75e-01	8.73e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	9.05e-01	9.38e-01	0.06890	-4.76e-02	-0.049800	7.49e-01	7.38e-01
MAP2K AND MAPK ACTIVATION	36	7.85e-01	8.62e-01	0.06880	3.07e-02	0.061600	7.50e-01	5.22e-01
RAC3 GTPASE CYCLE	88	5.24e-01	6.65e-01	0.06870	-1.90e-02	0.066000	7.59e-01	2.85e-01
SIGNALING BY NOTCH	188	2.90e-01	4.70e-01	0.06870	3.82e-02	0.057100	3.67e-01	1.78e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	100	5.14e-01	6.62e-01	0.06840	2.77e-02	0.062600	6.33e-01	2.80e-01
CELLULAR RESPONSE TO HEAT STRESS	95	5.35e-01	6.70e-01	0.06830	3.08e-02	0.060900	6.04e-01	3.05e-01
REPRODUCTION	75	5.75e-01	7.05e-01	0.06790	4.06e-02	-0.054400	5.43e-01	4.16e-01
ION HOMEOSTASIS	48	7.18e-01	8.12e-01	0.06740	-6.71e-02	0.006080	4.21e-01	9.42e-01
RHOF GTPASE CYCLE	40	7.53e-01	8.38e-01	0.06680	-3.21e-02	0.058600	7.25e-01	5.22e-01
SIGNALING BY NOTCH1	75	5.87e-01	7.11e-01	0.06660	4.03e-02	-0.053100	5.46e-01	4.27e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	183	2.82e-01	4.59e-01	0.06620	-3.35e-02	0.057100	4.35e-01	1.84e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	9.13e-01	9.44e-01	0.06610	6.59e-02	0.005130	6.69e-01	9.73e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	7.01e-01	7.96e-01	0.06520	-6.51e-02	-0.004130	3.99e-01	9.57e-01
G ALPHA S SIGNALLING EVENTS	103	5.00e-01	6.52e-01	0.06500	-3.47e-02	0.054900	5.43e-01	3.36e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	7.66e-01	8.48e-01	0.06460	-2.92e-02	-0.057600	7.35e-01	5.04e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	9.27e-01	9.51e-01	0.06440	3.95e-02	0.050900	8.05e-01	7.51e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	8.39e-01	9.01e-01	0.06440	-6.43e-02	0.003900	5.56e-01	9.71e-01
DNA DOUBLE STRAND BREAK REPAIR	136	4.54e-01	6.11e-01	0.06430	-3.38e-02	-0.054700	4.96e-01	2.71e-01
ION CHANNEL TRANSPORT	138	4.48e-01	6.06e-01	0.06420	-2.94e-02	-0.057100	5.51e-01	2.48e-01
METABOLISM OF STEROID HORMONES	20	8.86e-01	9.28e-01	0.06410	8.46e-03	0.063500	9.48e-01	6.23e-01
PI METABOLISM	79	6.17e-01	7.32e-01	0.06370	-6.36e-02	0.002970	3.29e-01	9.64e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	8.69e-01	9.17e-01	0.06350	3.81e-03	-0.063400	9.75e-01	5.99e-01
MHC CLASS II ANTIGEN PRESENTATION	103	5.45e-01	6.82e-01	0.06350	1.14e-02	0.062400	8.42e-01	2.74e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	8.46e-01	9.04e-01	0.06340	5.02e-02	-0.038700	6.58e-01	7.33e-01
CIRCADIAN CLOCK	68	6.53e-01	7.57e-01	0.06310	-2.47e-02	0.058000	7.25e-01	4.08e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	8.48e-01	9.05e-01	0.06270	5.97e-02	0.019100	5.78e-01	8.59e-01
RRNA PROCESSING IN THE MITOCHONDRION	10	9.47e-01	9.66e-01	0.06210	3.32e-02	0.052400	8.56e-01	7.74e-01
RET SIGNALING	37	8.07e-01	8.77e-01	0.06200	-1.62e-04	0.062000	9.99e-01	5.14e-01
NONHOMOLOGOUS END JOINING NHEJ	43	7.91e-01	8.66e-01	0.06200	-5.56e-02	-0.027400	5.28e-01	7.56e-01
ONCOGENE INDUCED SENESCENCE	32	8.41e-01	9.02e-01	0.06090	-1.51e-02	-0.059000	8.83e-01	5.63e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	8.62e-01	9.15e-01	0.06090	1.10e-02	-0.059900	9.23e-01	5.97e-01
REGULATION OF BETA CELL DEVELOPMENT	24	8.82e-01	9.26e-01	0.06090	-2.92e-02	-0.053400	8.05e-01	6.51e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	63	6.98e-01	7.93e-01	0.06050	-1.65e-02	0.058300	8.21e-01	4.24e-01
TRNA PROCESSING IN THE NUCLEUS	56	7.38e-01	8.27e-01	0.06050	-5.86e-03	-0.060200	9.40e-01	4.36e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	8.43e-01	9.03e-01	0.05890	-3.50e-02	-0.047400	7.20e-01	6.28e-01
CHROMOSOME MAINTENANCE	103	6.05e-01	7.26e-01	0.05890	2.98e-02	0.050800	6.01e-01	3.74e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	9.12e-01	9.43e-01	0.05890	-4.51e-02	-0.037800	7.34e-01	7.75e-01
SENSORY PERCEPTION	140	5.23e-01	6.65e-01	0.05750	3.11e-02	0.048400	5.26e-01	3.24e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	90	6.40e-01	7.49e-01	0.05750	-3.31e-04	0.057500	9.96e-01	3.46e-01
HIV TRANSCRIPTION ELONGATION	42	8.15e-01	8.84e-01	0.05720	5.71e-02	0.003540	5.22e-01	9.68e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	82	7.02e-01	7.97e-01	0.05550	-4.52e-02	-0.032200	4.80e-01	6.15e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	8.62e-01	9.15e-01	0.05530	-5.07e-02	-0.022200	6.09e-01	8.23e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	8.97e-01	9.36e-01	0.05490	5.16e-02	-0.018500	6.68e-01	8.78e-01
PRC2 METHYLATES HISTONES AND DNA	29	8.83e-01	9.26e-01	0.05280	5.22e-02	-0.008290	6.27e-01	9.38e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	8.79e-01	9.25e-01	0.05250	2.38e-02	0.046800	8.13e-01	6.42e-01
DEATH RECEPTOR SIGNALLING	134	5.70e-01	7.02e-01	0.05220	5.12e-02	-0.010500	3.07e-01	8.35e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	9.18e-01	9.45e-01	0.05090	-4.80e-02	0.016800	7.03e-01	8.94e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	9.30e-01	9.53e-01	0.05080	4.97e-02	-0.010700	7.15e-01	9.37e-01
VXPX CARGO TARGETING TO CILIUM	19	9.29e-01	9.53e-01	0.05060	5.06e-02	-0.001210	7.03e-01	9.93e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	8.27e-01	8.95e-01	0.04960	3.08e-02	-0.038900	7.12e-01	6.41e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	8.91e-01	9.32e-01	0.04910	-3.36e-02	-0.035900	7.35e-01	7.17e-01
L1CAM INTERACTIONS	109	6.79e-01	7.76e-01	0.04910	4.88e-02	0.005980	3.79e-01	9.14e-01
CELL CYCLE	588	1.33e-01	2.78e-01	0.04900	6.19e-03	0.048600	7.98e-01	4.51e-02
MITOCHONDRIAL TRNA AMINOACYLATION	21	9.24e-01	9.50e-01	0.04860	2.37e-02	-0.042400	8.51e-01	7.37e-01
SIGNALING BY NOTCH3	48	8.39e-01	9.01e-01	0.04850	1.32e-02	-0.046600	8.74e-01	5.76e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	51	8.25e-01	8.93e-01	0.04850	-3.70e-02	0.031300	6.47e-01	6.99e-01
SUMOYLATION	162	5.81e-01	7.07e-01	0.04830	-4.63e-02	-0.013800	3.09e-01	7.63e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	9.36e-01	9.58e-01	0.04810	4.80e-02	-0.003050	7.17e-01	9.82e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	9.00e-01	9.36e-01	0.04800	-4.79e-02	0.004100	6.50e-01	9.69e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	184	5.17e-01	6.63e-01	0.04800	-1.68e-02	0.044900	6.95e-01	2.94e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	7.68e-01	8.50e-01	0.04750	1.92e-02	-0.043500	7.75e-01	5.18e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	27	9.18e-01	9.45e-01	0.04560	5.95e-03	-0.045200	9.57e-01	6.85e-01
REGULATION OF TP53 ACTIVITY	148	6.19e-01	7.32e-01	0.04510	3.10e-02	-0.032700	5.15e-01	4.92e-01
DISEASES OF GLYCOSYLATION	124	6.71e-01	7.69e-01	0.04500	2.44e-02	-0.037800	6.39e-01	4.68e-01
DNA METHYLATION	20	9.38e-01	9.58e-01	0.04470	3.66e-02	-0.025700	7.77e-01	8.42e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	87	7.75e-01	8.55e-01	0.04420	-5.40e-04	-0.044200	9.93e-01	4.76e-01
EXTENSION OF TELOMERES	50	8.59e-01	9.13e-01	0.04370	3.82e-02	-0.021200	6.41e-01	7.95e-01
HCMV LATE EVENTS	64	8.28e-01	8.95e-01	0.04350	-4.14e-02	0.013300	5.67e-01	8.54e-01
RNA POLYMERASE II TRANSCRIPTION	1083	5.34e-02	1.50e-01	0.04340	-4.31e-02	0.005450	1.75e-02	7.64e-01
PD 1 SIGNALING	10	9.72e-01	9.83e-01	0.04280	4.22e-02	-0.007330	8.17e-01	9.68e-01
ACYL CHAIN REMODELLING OF PC	17	9.59e-01	9.75e-01	0.04200	2.90e-02	0.030500	8.36e-01	8.28e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	8.99e-01	9.36e-01	0.04100	6.26e-04	-0.041000	9.94e-01	6.46e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	9.67e-01	9.81e-01	0.04000	-3.34e-02	0.022000	8.35e-01	8.91e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE	35	9.17e-01	9.45e-01	0.04000	-7.60e-03	0.039300	9.38e-01	6.88e-01
PHOSPHOLIPID METABOLISM	185	6.41e-01	7.49e-01	0.04000	-2.77e-03	0.039900	9.48e-01	3.50e-01
MRNA CAPPING	29	9.37e-01	9.58e-01	0.03970	1.51e-02	0.036700	8.88e-01	7.32e-01
MEIOSIS	63	8.77e-01	9.25e-01	0.03800	-1.33e-02	-0.035600	8.55e-01	6.25e-01
GLYCOLYSIS	66	8.68e-01	9.17e-01	0.03780	-6.25e-05	0.037800	9.99e-01	5.95e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	61	8.92e-01	9.32e-01	0.03640	-1.70e-02	-0.032200	8.19e-01	6.64e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	9.48e-01	9.66e-01	0.03580	-3.07e-02	0.018400	7.86e-01	8.71e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	9.16e-01	9.45e-01	0.03460	-2.86e-02	-0.019400	7.21e-01	8.08e-01
DNA DOUBLE STRAND BREAK RESPONSE	52	9.18e-01	9.45e-01	0.03390	1.22e-02	0.031600	8.79e-01	6.94e-01
HYALURONAN METABOLISM	15	9.76e-01	9.86e-01	0.03190	-3.03e-02	0.009980	8.39e-01	9.47e-01
GOLGI TO ER RETROGRADE TRANSPORT	118	8.38e-01	9.01e-01	0.03110	-7.72e-03	0.030100	8.85e-01	5.72e-01
INTERLEUKIN 6 SIGNALING	10	9.89e-01	9.93e-01	0.02860	-1.79e-02	-0.022400	9.22e-01	9.02e-01
METABOLISM OF FAT SOLUBLE VITAMINS	31	9.63e-01	9.79e-01	0.02860	2.92e-03	0.028500	9.78e-01	7.84e-01
ONCOGENIC MAPK SIGNALING	77	9.25e-01	9.50e-01	0.02580	-3.43e-03	0.025600	9.59e-01	6.98e-01
RHOD GTPASE CYCLE	50	9.55e-01	9.72e-01	0.02580	1.51e-02	0.020900	8.54e-01	7.98e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	9.66e-01	9.80e-01	0.02350	3.97e-03	0.023100	9.64e-01	7.93e-01
TELOMERE MAINTENANCE	79	9.41e-01	9.61e-01	0.02330	9.99e-03	0.021100	8.78e-01	7.46e-01
P38MAPK EVENTS	13	9.89e-01	9.93e-01	0.02320	1.53e-02	-0.017400	9.24e-01	9.13e-01
G0 AND EARLY G1	24	9.80e-01	9.89e-01	0.02280	-1.52e-02	0.017000	8.98e-01	8.85e-01
MISMATCH REPAIR	14	9.90e-01	9.93e-01	0.02160	2.16e-02	0.000337	8.89e-01	9.98e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	9.93e-01	9.94e-01	0.01990	-1.40e-02	-0.014200	9.30e-01	9.30e-01
MUSCLE CONTRACTION	162	9.04e-01	9.38e-01	0.01970	1.51e-02	-0.012700	7.40e-01	7.81e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	9.69e-01	9.82e-01	0.01930	-1.54e-02	-0.011600	8.36e-01	8.76e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	85	9.64e-01	9.79e-01	0.01760	-1.06e-02	-0.014100	8.66e-01	8.22e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	35	9.87e-01	9.93e-01	0.01640	1.06e-02	0.012500	9.13e-01	8.98e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	77	9.71e-01	9.83e-01	0.01630	1.49e-02	0.006650	8.22e-01	9.20e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	9.91e-01	9.93e-01	0.01510	1.68e-03	-0.015100	9.88e-01	8.94e-01
SNRNP ASSEMBLY	51	9.83e-01	9.91e-01	0.01500	-4.36e-03	-0.014400	9.57e-01	8.59e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	42	9.91e-01	9.93e-01	0.01160	2.71e-03	-0.011300	9.76e-01	8.99e-01
ESTROGEN DEPENDENT GENE EXPRESSION	100	9.88e-01	9.93e-01	0.00920	-9.18e-03	-0.000556	8.74e-01	9.92e-01
TRANSCRIPTIONAL REGULATION BY TP53	338	9.76e-01	9.86e-01	0.00682	-4.05e-03	0.005490	8.98e-01	8.63e-01
FLT3 SIGNALING IN DISEASE	27	1.00e+00	1.00e+00	0.00120	-3.30e-04	0.001150	9.98e-01	9.92e-01

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Detailed Gene set reports

EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION

metric	value
setSize	87
pMANOVA	3.59e-25
p.adjustMANOVA	1.05e-22
s.dist	0.68
s.LPS	0.443
s.OVA	0.515
p.LPS	9.24e-13
p.OVA	9.3e-17

Top 20 genes

Gene	LPS	OVA
Rps8	7269	7309
Rpl23a	6015	7526
Rps9	5470	7584
Eef1a2	6134	6745
Rps29	6454	5764
Rps4x	5413	6683
Rps27a	5721	6253
Rpl23	5508	6486
Rpl6	5265	6716
Rps27l	4686	7434
Eef1g	4576	7432
Rpl37a	5424	6156
Rps25	4264	7814
Rpl24	4398	7497
Eef2	6018	5219
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300

Click HERE to show all gene set members

All member genes

	LPS	OVA
Eef1a1	-2823	7023
Eef1a2	6134	6745
Eef1b2	2756	5400
Eef1d	6661	3423
Eef1g	4576	7432
Eef2	6018	5219
Fau	3642	5713
Rpl10	3681	-3707
Rpl10a	887	725
Rpl11	2278	5271
Rpl12	3715	-7459
Rpl13	3904	3220
Rpl13a	405	6090
Rpl14	3947	5501
Rpl15	-3300	3005
Rpl17	-2674	5569
Rpl18	1839	261
Rpl18a	3851	5321
Rpl19	2619	3550
Rpl21	2971	2664
Rpl22	727	5843
Rpl22l1	-3342	6907
Rpl23	5508	6486
Rpl23a	6015	7526
Rpl24	4398	7497
Rpl26	7183	3616
Rpl27	526	5180
Rpl27a	2840	2777
Rpl28	6951	830
Rpl29	-308	3645
Rpl3	2605	5902
Rpl30	3372	5167
Rpl31	3208	5659
Rpl32	3941	4603
Rpl34	-368	3497
Rpl35	6121	4242
Rpl35a	4654	5451
Rpl36	2400	-378
Rpl36a	919	4018
Rpl36al	2700	1803
Rpl37	5410	2939
Rpl37a	5424	6156
Rpl38	6478	3980
Rpl39	-2409	4847
Rpl4	866	6114
Rpl5	1278	6005
Rpl6	5265	6716
Rpl7	-1345	4991
Rpl7a	4402	2277
Rpl8	5073	2661
Rpl9	1473	5111
Rplp0	-305	5857
Rplp1	4410	-555
Rplp2	6464	772
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098
Uba52	3801	4656

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TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

metric	value
setSize	11
pMANOVA	0.000853
p.adjustMANOVA	0.00642
s.dist	0.658
s.LPS	0.0789
s.OVA	0.654
p.LPS	0.65
p.OVA	0.000174

Top 20 genes

Gene	LPS	OVA
Unc93b1	5057	5731
Ctsl	4754	5446
Ctsk	3969	4371
Tlr7	2249	7062
Hsp90b1	2500	6284
Lgmn	922	7880

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cnpy3	-1459	1644
Ctsb	-1703	7800
Ctsk	3969	4371
Ctsl	4754	5446
Ctss	-1895	7906
Hsp90b1	2500	6284
Lgmn	922	7880
Tlr3	-7409	4630
Tlr7	2249	7062
Tlr9	-5004	-1431
Unc93b1	5057	5731

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MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1

metric	value
setSize	11
pMANOVA	0.00129
p.adjustMANOVA	0.00888
s.dist	0.618
s.LPS	-0.567
s.OVA	0.245
p.LPS	0.00112
p.OVA	0.16

Top 20 genes

Gene	LPS	OVA
Rap1b	-8318	6947
Rac1	-7036	7670
Gab1	-4803	7454
Rap1a	-5206	6754
Crk	-5149	6483
Crkl	-5466	4716
Grb2	-3203	1149

Click HERE to show all gene set members

All member genes

	LPS	OVA
Crk	-5149	6483
Crkl	-5466	4716
Dock7	-6766	-8138
Gab1	-4803	7454
Grb2	-3203	1149
Hgf	-7725	-5021
Met	-7731	-4405
Rac1	-7036	7670
Rap1a	-5206	6754
Rap1b	-8318	6947
Rapgef1	4587	-3482

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COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS

metric	value
setSize	56
pMANOVA	1.26e-13
p.adjustMANOVA	7.33e-12
s.dist	0.612
s.LPS	0.295
s.OVA	0.536
p.LPS	0.000133
p.OVA	3.88e-12

Top 20 genes

Gene	LPS	OVA
Timmdc1	7357	7319
Ndufa12	6998	7523
Ndufa10	5715	7438
Ndufaf1	5653	7100
Ndufa13	6592	5812
Ndufs2	4508	7474
Ndufaf2	4874	6154
Ndufaf6	4271	6561
Ndufs5	5914	4689
Ndufa6	5352	4748
Tmem126b	7101	3219
Ndufs6	5835	3821
Ndufb8	3172	6153
Ndufv1	5328	3456
Ndufs4	2427	7475
Ndufb5	2197	7899
Ndufb3	6621	2486
Ndufb9	2239	6715
Ndufa5	1897	7071
Ndufaf5	2350	5651

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acad9	608	1981
Ecsit	1595	2336
mt-Nd1	-3437	7547
mt-Nd2	-4161	7398
mt-Nd3	-125	7652
mt-Nd4	-4483	7747
mt-Nd5	-4792	7472
mt-Nd6	-5972	7648
Ndufa1	4455	2808
Ndufa10	5715	7438
Ndufa11	2653	-920
Ndufa12	6998	7523
Ndufa13	6592	5812
Ndufa2	3298	-1358
Ndufa3	5066	-187
Ndufa5	1897	7071
Ndufa6	5352	4748
Ndufa7	1187	4511
Ndufa8	3953	1692
Ndufa9	214	-1151
Ndufab1	1653	5587
Ndufaf1	5653	7100
Ndufaf2	4874	6154
Ndufaf3	-710	-1141
Ndufaf4	-86	7830
Ndufaf5	2350	5651
Ndufaf6	4271	6561
Ndufaf7	952	-1197
Ndufb1	-3377	3408
Ndufb10	7581	314
Ndufb11	56	6442
Ndufb2	5312	1230
Ndufb3	6621	2486
Ndufb4	-1779	6522
Ndufb5	2197	7899
Ndufb6	2316	4162
Ndufb7	4405	1364
Ndufb8	3172	6153
Ndufb9	2239	6715
Ndufc1	575	7834
Ndufc2	-860	4791
Ndufs1	-1826	6346
Ndufs2	4508	7474
Ndufs3	-2761	5967
Ndufs4	2427	7475
Ndufs5	5914	4689
Ndufs6	5835	3821
Ndufs7	4329	2096
Ndufs8	2347	349
Ndufv1	5328	3456
Ndufv2	-2931	7852
Ndufv3	1927	201
Nubpl	-4045	24
Timmdc1	7357	7319
Tmem126b	7101	3219
Tmem186	333	-7228

---

---

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

metric	value
setSize	94
pMANOVA	1.66e-21
p.adjustMANOVA	2.15e-19
s.dist	0.603
s.LPS	0.38
s.OVA	0.468
p.LPS	1.94e-10
p.OVA	4.37e-15

Top 20 genes

Gene	LPS	OVA
Rps8	7269	7309
Rpl23a	6015	7526
Rps9	5470	7584
Rps29	6454	5764
Rps4x	5413	6683
Rps27a	5721	6253
Rpl23	5508	6486
Rpl6	5265	6716
Rps27l	4686	7434
Rpl37a	5424	6156
Rps25	4264	7814
Rpl24	4398	7497
Ddit3	7454	4239
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300
Rpl26	7183	3616
Rpl35	6121	4242

Click HERE to show all gene set members

All member genes

	LPS	OVA
Asns	-6224	7462
Atf2	-8293	1693
Atf3	2584	-1128
Atf4	3752	-2098
Cebpb	-4190	4494
Cebpg	-1728	646
Ddit3	7454	4239
Eif2ak4	833	-8346
Eif2s1	-1078	7334
Eif2s2	-1382	7342
Eif2s3x	-1911	7278
Fau	3642	5713
Gcn1	6033	-7702
Impact	871	5521
Rpl10	3681	-3707
Rpl10a	887	725
Rpl11	2278	5271
Rpl12	3715	-7459
Rpl13	3904	3220
Rpl13a	405	6090
Rpl14	3947	5501
Rpl15	-3300	3005
Rpl17	-2674	5569
Rpl18	1839	261
Rpl18a	3851	5321
Rpl19	2619	3550
Rpl21	2971	2664
Rpl22	727	5843
Rpl22l1	-3342	6907
Rpl23	5508	6486
Rpl23a	6015	7526
Rpl24	4398	7497
Rpl26	7183	3616
Rpl27	526	5180
Rpl27a	2840	2777
Rpl28	6951	830
Rpl29	-308	3645
Rpl3	2605	5902
Rpl30	3372	5167
Rpl31	3208	5659
Rpl32	3941	4603
Rpl34	-368	3497
Rpl35	6121	4242
Rpl35a	4654	5451
Rpl36	2400	-378
Rpl36a	919	4018
Rpl36al	2700	1803
Rpl37	5410	2939
Rpl37a	5424	6156
Rpl38	6478	3980
Rpl39	-2409	4847
Rpl4	866	6114
Rpl5	1278	6005
Rpl6	5265	6716
Rpl7	-1345	4991
Rpl7a	4402	2277
Rpl8	5073	2661
Rpl9	1473	5111
Rplp0	-305	5857
Rplp1	4410	-555
Rplp2	6464	772
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098
Uba52	3801	4656

---

---

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

metric	value
setSize	12
pMANOVA	0.00227
p.adjustMANOVA	0.0143
s.dist	0.601
s.LPS	0.372
s.OVA	0.472
p.LPS	0.0257
p.OVA	0.00465

Top 20 genes

Gene	LPS	OVA
Elovl1	7795	8073
Hsd17b4	4859	7354
Fads2	4719	4713
Fads1	5080	4254
Scp2	1586	7594
Elovl5	403	7730

Click HERE to show all gene set members

All member genes

	LPS	OVA
Abcd1	5577	-2467
Acaa1a	5943	-6780
Acot8	5671	-1053
Acox1	-5295	5263
Acsl1	-4198	4259
Elovl1	7795	8073
Elovl2	-895	5553
Elovl5	403	7730
Fads1	5080	4254
Fads2	4719	4713
Hsd17b4	4859	7354
Scp2	1586	7594

---

---

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

metric	value
setSize	106
pMANOVA	3.87e-23
p.adjustMANOVA	6.45e-21
s.dist	0.588
s.LPS	0.324
s.OVA	0.491
p.LPS	8.1e-09
p.OVA	2.38e-18

Top 20 genes

Gene	LPS	OVA
Rps8	7269	7309
Rpl23a	6015	7526
Rps9	5470	7584
Rps29	6454	5764
Srp72	5011	7221
Rps4x	5413	6683
Rps27a	5721	6253
Rpl23	5508	6486
Rpl6	5265	6716
Rps27l	4686	7434
Rpl37a	5424	6156
Rps25	4264	7814
Rpl24	4398	7497
Srpr	4716	6546
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300
Sec11c	4096	6779

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ddost	-1461	6071
Fau	3642	5713
Rpl10	3681	-3707
Rpl10a	887	725
Rpl11	2278	5271
Rpl12	3715	-7459
Rpl13	3904	3220
Rpl13a	405	6090
Rpl14	3947	5501
Rpl15	-3300	3005
Rpl17	-2674	5569
Rpl18	1839	261
Rpl18a	3851	5321
Rpl19	2619	3550
Rpl21	2971	2664
Rpl22	727	5843
Rpl22l1	-3342	6907
Rpl23	5508	6486
Rpl23a	6015	7526
Rpl24	4398	7497
Rpl26	7183	3616
Rpl27	526	5180
Rpl27a	2840	2777
Rpl28	6951	830
Rpl29	-308	3645
Rpl3	2605	5902
Rpl30	3372	5167
Rpl31	3208	5659
Rpl32	3941	4603
Rpl34	-368	3497
Rpl35	6121	4242
Rpl35a	4654	5451
Rpl36	2400	-378
Rpl36a	919	4018
Rpl36al	2700	1803
Rpl37	5410	2939
Rpl37a	5424	6156
Rpl38	6478	3980
Rpl39	-2409	4847
Rpl4	866	6114
Rpl5	1278	6005
Rpl6	5265	6716
Rpl7	-1345	4991
Rpl7a	4402	2277
Rpl8	5073	2661
Rpl9	1473	5111
Rplp0	-305	5857
Rplp1	4410	-555
Rplp2	6464	772
Rpn1	-4160	2583
Rpn2	1732	3254
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098
Sec11a	3183	816
Sec11c	4096	6779
Sec61a1	-2394	-5455
Sec61a2	1707	-6142
Sec61b	1066	2089
Sec61g	-4233	3214
Spcs1	759	7922
Spcs2	-1136	5440
Spcs3	-7044	6006
Srp14	938	3818
Srp19	3296	4093
Srp54a	-5651	7016
Srp68	968	-975
Srp72	5011	7221
Srp9	-3091	5615
Srpr	4716	6546
Srprb	3731	5427
Ssr1	-5626	5006
Ssr2	-2630	4033
Ssr3	-5720	7546
Ssr4	-186	-81
Tram1	-8098	2524
Uba52	3801	4656

---

---

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

metric	value
setSize	19
pMANOVA	3.08e-05
p.adjustMANOVA	0.000427
s.dist	0.588
s.LPS	-0.222
s.OVA	0.545
p.LPS	0.0934
p.OVA	3.94e-05

Top 20 genes

Gene	LPS	OVA
P2ry12	-6746	7371
Gng12	-6342	7762
Gnai1	-8727	5036
Gng10	-5606	7084
Gnai3	-5034	6993
Gnb4	-8083	2628
Gng2	-8001	1552
Gng5	-818	7006
Gnai2	-1157	4083
Gnb1	-6678	592
Gng13	-3686	918
Gng11	-360	6592
Gng7	-405	5101
Gnb2	-173	1359

Click HERE to show all gene set members

All member genes

	LPS	OVA
Gnai1	-8727	5036
Gnai2	-1157	4083
Gnai3	-5034	6993
Gnb1	-6678	592
Gnb2	-173	1359
Gnb4	-8083	2628
Gnb5	2322	6656
Gng10	-5606	7084
Gng11	-360	6592
Gng12	-6342	7762
Gng13	-3686	918
Gng2	-8001	1552
Gng3	4649	4211
Gng4	688	2010
Gng5	-818	7006
Gng7	-405	5101
Gng8	5762	2068
Gngt2	4501	2828
P2ry12	-6746	7371

---

---

INITIAL TRIGGERING OF COMPLEMENT

INITIAL TRIGGERING OF COMPLEMENT

metric	value
setSize	10
pMANOVA	0.00852
p.adjustMANOVA	0.0396
s.dist	0.582
s.LPS	0.474
s.OVA	0.337
p.LPS	0.00942
p.OVA	0.0649

Top 20 genes

Gene	LPS	OVA
C1qb	6799	7122
C2	7641	5519
C1qc	4296	7483
C1qa	2948	7430
Masp1	2774	7044
C4b	4806	3711

Click HERE to show all gene set members

All member genes

	LPS	OVA
C1qa	2948	7430
C1qb	6799	7122
C1qc	4296	7483
C2	7641	5519
C4b	4806	3711
Cfb	-7654	-6022
Cfp	7564	-1864
Gzmm	-541	-2227
Masp1	2774	7044
Masp2	5858	-2258

---

---

CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY

metric	value
setSize	10
pMANOVA	0.00458
p.adjustMANOVA	0.0245
s.dist	0.578
s.LPS	-0.409
s.OVA	0.408
p.LPS	0.0251
p.OVA	0.0253

Top 20 genes

Gene	LPS	OVA
Rac1	-7036	7670
Cdc42	-6734	6326
Pak1	-7207	4464
Cd86	-6899	4265
Pak2	-2249	7894
Pak3	-3652	4264
Grb2	-3203	1149
Fyn	-3965	235

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cd86	-6899	4265
Cdc42	-6734	6326
Fyn	-3965	235
Grb2	-3203	1149
Lck	-5195	-4236
Pak1	-7207	4464
Pak2	-2249	7894
Pak3	-3652	4264
Rac1	-7036	7670
Vav1	7575	-197

---

---

EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION

metric	value
setSize	114
pMANOVA	6.39e-23
p.adjustMANOVA	9.31e-21
s.dist	0.565
s.LPS	0.306
s.OVA	0.475
p.LPS	1.75e-08
p.OVA	1.98e-18

Top 20 genes

Gene	LPS	OVA
Rps8	7269	7309
Rpl23a	6015	7526
Rps9	5470	7584
Eif5b	7138	5415
Rps29	6454	5764
Rps4x	5413	6683
Rps27a	5721	6253
Rpl23	5508	6486
Rpl6	5265	6716
Rps27l	4686	7434
Rpl37a	5424	6156
Rps25	4264	7814
Rpl24	4398	7497
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300
Rpl26	7183	3616
Rpl35	6121	4242

Click HERE to show all gene set members

All member genes

	LPS	OVA
Eif1ax	-7593	3725
Eif2b1	-7905	-2147
Eif2b2	4322	4484
Eif2b3	-6509	-1339
Eif2b4	6272	2991
Eif2b5	2116	3309
Eif2s1	-1078	7334
Eif2s2	-1382	7342
Eif2s3x	-1911	7278
Eif3a	7515	-4662
Eif3b	3392	1727
Eif3c	2560	2726
Eif3d	384	142
Eif3e	-7886	6871
Eif3f	2086	5717
Eif3g	3250	4179
Eif3h	2547	5339
Eif3i	2097	2268
Eif3j1	2129	346
Eif3j2	-2616	7283
Eif3k	-2270	-1119
Eif3l	-593	3716
Eif3m	-7076	6797
Eif4a1	-1988	2217
Eif4a2	-7548	5782
Eif4b	-1893	4200
Eif4e	-4688	6657
Eif4ebp1	1853	3169
Eif4g1	5626	-6388
Eif4h	-2503	-1074
Eif5	-7015	4890
Eif5b	7138	5415
Fau	3642	5713
Pabpc1	-1115	6437
Rpl10	3681	-3707
Rpl10a	887	725
Rpl11	2278	5271
Rpl12	3715	-7459
Rpl13	3904	3220
Rpl13a	405	6090
Rpl14	3947	5501
Rpl15	-3300	3005
Rpl17	-2674	5569
Rpl18	1839	261
Rpl18a	3851	5321
Rpl19	2619	3550
Rpl21	2971	2664
Rpl22	727	5843
Rpl22l1	-3342	6907
Rpl23	5508	6486
Rpl23a	6015	7526
Rpl24	4398	7497
Rpl26	7183	3616
Rpl27	526	5180
Rpl27a	2840	2777
Rpl28	6951	830
Rpl29	-308	3645
Rpl3	2605	5902
Rpl30	3372	5167
Rpl31	3208	5659
Rpl32	3941	4603
Rpl34	-368	3497
Rpl35	6121	4242
Rpl35a	4654	5451
Rpl36	2400	-378
Rpl36a	919	4018
Rpl36al	2700	1803
Rpl37	5410	2939
Rpl37a	5424	6156
Rpl38	6478	3980
Rpl39	-2409	4847
Rpl4	866	6114
Rpl5	1278	6005
Rpl6	5265	6716
Rpl7	-1345	4991
Rpl7a	4402	2277
Rpl8	5073	2661
Rpl9	1473	5111
Rplp0	-305	5857
Rplp1	4410	-555
Rplp2	6464	772
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098
Uba52	3801	4656

---

---

NUCLEOTIDE LIKE PURINERGIC RECEPTORS

NUCLEOTIDE LIKE PURINERGIC RECEPTORS

metric	value
setSize	13
pMANOVA	0.00244
p.adjustMANOVA	0.0149
s.dist	0.557
s.LPS	0.0356
s.OVA	0.556
p.LPS	0.824
p.OVA	0.000524

Top 20 genes

Gene	LPS	OVA
Adora3	6377	7065
Gpr17	7438	5816
P2ry1	4895	7335
Adora2b	4071	5004
P2ry13	1703	5875
Lpar6	2149	567

Click HERE to show all gene set members

All member genes

	LPS	OVA
Adora1	-3794	928
Adora2a	-426	4685
Adora2b	4071	5004
Adora3	6377	7065
Gpr17	7438	5816
Lpar4	-7642	2281
Lpar6	2149	567
P2ry1	4895	7335
P2ry12	-6746	7371
P2ry13	1703	5875
P2ry14	-794	7051
P2ry2	-6591	-494
P2ry6	-2960	3701

---

---

RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT

metric	value
setSize	102
pMANOVA	4.13e-20
p.adjustMANOVA	4.38e-18
s.dist	0.553
s.LPS	0.21
s.OVA	0.512
p.LPS	0.000246
p.OVA	3.92e-19

Top 20 genes

Gene	LPS	OVA
Timmdc1	7357	7319
Ndufa12	6998	7523
Ndufa10	5715	7438
Ndufaf1	5653	7100
Ndufa13	6592	5812
Ndufs2	4508	7474
Ndufaf2	4874	6154
Ndufaf6	4271	6561
Ndufs5	5914	4689
Sco2	4448	5969
Ndufa6	5352	4748
Taco1	5103	4947
Cox5b	4770	5257
Surf1	3345	6962
Tmem126b	7101	3219
Ndufs6	5835	3821
Cox5a	2967	7056
Coq10a	3815	5334
Ndufb8	3172	6153
Ndufv1	5328	3456

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acad9	608	1981
Coq10a	3815	5334
Coq10b	-3900	7972
Cox11	4944	-7059
Cox14	-791	-2266
Cox16	-5837	4702
Cox18	1918	4164
Cox19	6179	-4411
Cox20	494	5292
Cox4i1	2759	419
Cox5a	2967	7056
Cox5b	4770	5257
Cox6a1	533	6489
Cox6b1	3314	1740
Cox6c	1236	4892
Cox7a2l	1780	7722
Cox7b	367	4500
Cox7c	1266	5795
Cox8a	139	4534
Cyc1	1431	2316
Cycs	-4448	7302
Ecsit	1595	2336
Etfa	-2755	3110
Etfb	-1009	1992
Etfdh	-5075	1102
Lrpprc	-4802	-6897
mt-Co1	-2709	7832
mt-Co2	-2570	7453
mt-Co3	-1213	7241
mt-Cytb	-1700	7368
mt-Nd1	-3437	7547
mt-Nd2	-4161	7398
mt-Nd3	-125	7652
mt-Nd4	-4483	7747
mt-Nd5	-4792	7472
mt-Nd6	-5972	7648
Ndufa1	4455	2808
Ndufa10	5715	7438
Ndufa11	2653	-920
Ndufa12	6998	7523
Ndufa13	6592	5812
Ndufa2	3298	-1358
Ndufa3	5066	-187
Ndufa4	647	6888
Ndufa5	1897	7071
Ndufa6	5352	4748
Ndufa7	1187	4511
Ndufa8	3953	1692
Ndufa9	214	-1151
Ndufab1	1653	5587
Ndufaf1	5653	7100
Ndufaf2	4874	6154
Ndufaf3	-710	-1141
Ndufaf4	-86	7830
Ndufaf5	2350	5651
Ndufaf6	4271	6561
Ndufaf7	952	-1197
Ndufb1	-3377	3408
Ndufb10	7581	314
Ndufb11	56	6442
Ndufb2	5312	1230
Ndufb3	6621	2486
Ndufb4	-1779	6522
Ndufb5	2197	7899
Ndufb6	2316	4162
Ndufb7	4405	1364
Ndufb8	3172	6153
Ndufb9	2239	6715
Ndufc1	575	7834
Ndufc2	-860	4791
Ndufs1	-1826	6346
Ndufs2	4508	7474
Ndufs3	-2761	5967
Ndufs4	2427	7475
Ndufs5	5914	4689
Ndufs6	5835	3821
Ndufs7	4329	2096
Ndufs8	2347	349
Ndufv1	5328	3456
Ndufv2	-2931	7852
Ndufv3	1927	201
Nubpl	-4045	24
Sco1	-8421	89
Sco2	4448	5969
Sdha	-195	5190
Sdhb	-706	4437
Sdhc	266	7696
Sdhd	-1586	4980
Surf1	3345	6962
Taco1	5103	4947
Timmdc1	7357	7319
Tmem126b	7101	3219
Tmem186	333	-7228
Trap1	6956	-274
Uqcr10	2812	941
Uqcr11	2518	-883
Uqcrb	2530	7255
Uqcrc1	3152	822
Uqcrc2	-6454	5459
Uqcrfs1	-1373	3878
Uqcrh	1339	3287
Uqcrq	2765	4378

---

---

PINK1 PRKN MEDIATED MITOPHAGY

PINK1 PRKN MEDIATED MITOPHAGY

metric	value
setSize	22
pMANOVA	6.14e-05
p.adjustMANOVA	0.000738
s.dist	0.553
s.LPS	0.188
s.OVA	0.521
p.LPS	0.127
p.OVA	2.36e-05

Top 20 genes

Gene	LPS	OVA
Rps27a	5721	6253
Prkn	7375	4057
Map1lc3a	5523	4269
Tomm6	3226	6850
Uba52	3801	4656
Map1lc3b	2143	5936
Ubb	2566	4439
Vdac1	1584	5837
Tomm7	2623	2388
Mterf3	1370	4077
Sqstm1	722	5401
Tomm40	3703	1046
Tomm5	1860	1984

Click HERE to show all gene set members

All member genes

	LPS	OVA
Atg12	-4513	4907
Atg5	-3858	6426
Map1lc3a	5523	4269
Map1lc3b	2143	5936
Mfn1	5450	-1471
Mfn2	4722	-564
Mterf3	1370	4077
Pink1	-1899	5577
Prkn	7375	4057
Rps27a	5721	6253
Sqstm1	722	5401
Tomm20	-7837	7654
Tomm22	-5399	5772
Tomm40	3703	1046
Tomm5	1860	1984
Tomm6	3226	6850
Tomm7	2623	2388
Tomm70a	-8174	5555
Uba52	3801	4656
Ubb	2566	4439
Ubc	3034	-673
Vdac1	1584	5837

---

---

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL

metric	value
setSize	12
pMANOVA	0.00573
p.adjustMANOVA	0.0283
s.dist	0.553
s.LPS	0.32
s.OVA	0.451
p.LPS	0.0553
p.OVA	0.00681

Top 20 genes

Gene	LPS	OVA
Ptgis	7582	6045
Rxra	5738	6255
Hsd17b4	4859	7354
Hsd3b7	4571	7469
Cyp27a1	5717	4414
Slc27a2	6192	2593
Scp2	1586	7594

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acot8	5671	-1053
Amacr	-5665	2232
Cyp27a1	5717	4414
Cyp7b1	-691	4704
Hsd17b4	4859	7354
Hsd3b7	4571	7469
Ncoa1	-5288	-2924
Ncoa2	-4236	-2251
Ptgis	7582	6045
Rxra	5738	6255
Scp2	1586	7594
Slc27a2	6192	2593

---

---

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

metric	value
setSize	59
pMANOVA	9.83e-12
p.adjustMANOVA	4.77e-10
s.dist	0.551
s.LPS	0.27
s.OVA	0.48
p.LPS	0.000332
p.OVA	1.75e-10

Top 20 genes

Gene	LPS	OVA
Rps8	7269	7309
Rps9	5470	7584
Rps29	6454	5764
Rps4x	5413	6683
Rps27a	5721	6253
Rps27l	4686	7434
Rps25	4264	7814
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300
Fau	3642	5713
Rps24	3022	6357
Rps21	5587	3173
Rps7	2681	6267
Eif3h	2547	5339
Eif3g	3250	4179
Rps11	3856	3501
Rps13	5831	2141

Click HERE to show all gene set members

All member genes

	LPS	OVA
Eif1ax	-7593	3725
Eif2s1	-1078	7334
Eif2s2	-1382	7342
Eif2s3x	-1911	7278
Eif3a	7515	-4662
Eif3b	3392	1727
Eif3c	2560	2726
Eif3d	384	142
Eif3e	-7886	6871
Eif3f	2086	5717
Eif3g	3250	4179
Eif3h	2547	5339
Eif3i	2097	2268
Eif3j1	2129	346
Eif3j2	-2616	7283
Eif3k	-2270	-1119
Eif3l	-593	3716
Eif3m	-7076	6797
Eif4a1	-1988	2217
Eif4a2	-7548	5782
Eif4b	-1893	4200
Eif4e	-4688	6657
Eif4ebp1	1853	3169
Eif4g1	5626	-6388
Eif4h	-2503	-1074
Fau	3642	5713
Pabpc1	-1115	6437
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098

---

---

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

metric	value
setSize	11
pMANOVA	0.00465
p.adjustMANOVA	0.0245
s.dist	0.551
s.LPS	-0.432
s.OVA	0.342
p.LPS	0.013
p.OVA	0.0497

Top 20 genes

Gene	LPS	OVA
Prkar2b	-8282	6950
Prkacb	-8480	6485
Prkar1a	-7928	6048
Creb1	-7585	5215
Calm1	-6747	5510
Prkx	-7100	4041
Prkar1b	-540	3037

Click HERE to show all gene set members

All member genes

	LPS	OVA
Adcy1	-4526	-7621
Adcy8	658	-7261
Calm1	-6747	5510
Creb1	-7585	5215
Prkaca	1753	1
Prkacb	-8480	6485
Prkar1a	-7928	6048
Prkar1b	-540	3037
Prkar2a	4256	6537
Prkar2b	-8282	6950
Prkx	-7100	4041

---

---

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

metric	value
setSize	125
pMANOVA	4.86e-24
p.adjustMANOVA	1.13e-21
s.dist	0.549
s.LPS	0.216
s.OVA	0.505
p.LPS	3.17e-05
p.OVA	1.81e-22

Top 20 genes

Gene	LPS	OVA
Timmdc1	7357	7319
Ndufa12	6998	7523
Ndufa10	5715	7438
Ndufaf1	5653	7100
Ndufa13	6592	5812
Ndufs2	4508	7474
Ndufaf2	4874	6154
Ndufaf6	4271	6561
Ndufs5	5914	4689
Sco2	4448	5969
Ucp2	3845	6673
Ndufa6	5352	4748
Taco1	5103	4947
Cox5b	4770	5257
Pm20d1	5121	4737
Surf1	3345	6962
Tmem126b	7101	3219
Ndufs6	5835	3821
Atp5b	2777	7881
Cox5a	2967	7056

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acad9	608	1981
Atp5a1	-4979	7815
Atp5b	2777	7881
Atp5c1	-5844	7552
Atp5d	3989	1763
Atp5e	1649	1321
Atp5g1	5849	1062
Atp5g2	-6493	-3010
Atp5g3	3186	4173
Atp5h	1671	6021
Atp5j	4104	3760
Atp5j2	4355	1374
Atp5k	7163	360
Atp5l	-831	1707
Atp5o	3993	3961
Atp5pb	-1235	7179
Coq10a	3815	5334
Coq10b	-3900	7972
Cox11	4944	-7059
Cox14	-791	-2266
Cox16	-5837	4702
Cox18	1918	4164
Cox19	6179	-4411
Cox20	494	5292
Cox4i1	2759	419
Cox5a	2967	7056
Cox5b	4770	5257
Cox6a1	533	6489
Cox6b1	3314	1740
Cox6c	1236	4892
Cox7a2l	1780	7722
Cox7b	367	4500
Cox7c	1266	5795
Cox8a	139	4534
Cyc1	1431	2316
Cycs	-4448	7302
Dmac2l	-2606	2799
Ecsit	1595	2336
Etfa	-2755	3110
Etfb	-1009	1992
Etfdh	-5075	1102
Lrpprc	-4802	-6897
mt-Atp6	-2868	6502
mt-Atp8	994	6358
mt-Co1	-2709	7832
mt-Co2	-2570	7453
mt-Co3	-1213	7241
mt-Cytb	-1700	7368
mt-Nd1	-3437	7547
mt-Nd2	-4161	7398
mt-Nd3	-125	7652
mt-Nd4	-4483	7747
mt-Nd5	-4792	7472
mt-Nd6	-5972	7648
Ndufa1	4455	2808
Ndufa10	5715	7438
Ndufa11	2653	-920
Ndufa12	6998	7523
Ndufa13	6592	5812
Ndufa2	3298	-1358
Ndufa3	5066	-187
Ndufa4	647	6888
Ndufa5	1897	7071
Ndufa6	5352	4748
Ndufa7	1187	4511
Ndufa8	3953	1692
Ndufa9	214	-1151
Ndufab1	1653	5587
Ndufaf1	5653	7100
Ndufaf2	4874	6154
Ndufaf3	-710	-1141
Ndufaf4	-86	7830
Ndufaf5	2350	5651
Ndufaf6	4271	6561
Ndufaf7	952	-1197
Ndufb1	-3377	3408
Ndufb10	7581	314
Ndufb11	56	6442
Ndufb2	5312	1230
Ndufb3	6621	2486
Ndufb4	-1779	6522
Ndufb5	2197	7899
Ndufb6	2316	4162
Ndufb7	4405	1364
Ndufb8	3172	6153
Ndufb9	2239	6715
Ndufc1	575	7834
Ndufc2	-860	4791
Ndufs1	-1826	6346
Ndufs2	4508	7474
Ndufs3	-2761	5967
Ndufs4	2427	7475
Ndufs5	5914	4689
Ndufs6	5835	3821
Ndufs7	4329	2096
Ndufs8	2347	349
Ndufv1	5328	3456
Ndufv2	-2931	7852
Ndufv3	1927	201
Nubpl	-4045	24
Pm20d1	5121	4737
Sco1	-8421	89
Sco2	4448	5969
Sdha	-195	5190
Sdhb	-706	4437
Sdhc	266	7696
Sdhd	-1586	4980
Slc25a14	475	6786
Slc25a27	7307	-6515
Surf1	3345	6962
Taco1	5103	4947
Timmdc1	7357	7319
Tmem126b	7101	3219
Tmem186	333	-7228
Trap1	6956	-274
Ucp2	3845	6673
Ucp3	2554	3994
Uqcr10	2812	941
Uqcr11	2518	-883
Uqcrb	2530	7255
Uqcrc1	3152	822
Uqcrc2	-6454	5459
Uqcrfs1	-1373	3878
Uqcrh	1339	3287
Uqcrq	2765	4378

---

---

COLLAGEN CHAIN TRIMERIZATION

COLLAGEN CHAIN TRIMERIZATION

metric	value
setSize	39
pMANOVA	9.52e-09
p.adjustMANOVA	3.36e-07
s.dist	0.543
s.LPS	0.423
s.OVA	-0.34
p.LPS	4.8e-06
p.OVA	0.00024

Top 20 genes

Gene	LPS	OVA
Col12a1	7484	-6936
Col4a2	5545	-8019
Col26a1	7584	-5443
Col5a2	6824	-5299
Col2a1	6841	-4900
Col5a3	6553	-5014
Col27a1	7549	-4072
Col15a1	4514	-5174
Col6a2	6148	-2781
Col1a1	2552	-6406
Col6a3	4528	-3519
Col20a1	1833	-7961
Col6a1	5823	-2243
Col17a1	2348	-4166
Col16a1	7191	-959
Col9a3	3714	-1615
Col28a1	4668	-1079
Col6a5	2314	-1938
Col24a1	2944	-944
Col11a1	1206	-2090

Click HERE to show all gene set members

All member genes

	LPS	OVA
Col11a1	1206	-2090
Col11a2	7498	56
Col12a1	7484	-6936
Col13a1	7709	1905
Col14a1	-443	-4932
Col15a1	4514	-5174
Col16a1	7191	-959
Col17a1	2348	-4166
Col18a1	2997	366
Col19a1	-584	-7443
Col1a1	2552	-6406
Col1a2	7309	5847
Col20a1	1833	-7961
Col22a1	-5297	-7873
Col23a1	-3639	-8072
Col24a1	2944	-944
Col25a1	-5131	-4678
Col26a1	7584	-5443
Col27a1	7549	-4072
Col28a1	4668	-1079
Col2a1	6841	-4900
Col3a1	5848	1993
Col4a1	-836	-8183
Col4a2	5545	-8019
Col4a3	1820	-751
Col4a5	2442	175
Col5a1	-930	-7207
Col5a2	6824	-5299
Col5a3	6553	-5014
Col6a1	5823	-2243
Col6a2	6148	-2781
Col6a3	4528	-3519
Col6a5	2314	-1938
Col6a6	-5080	-3951
Col7a1	6652	703
Col8a1	-750	5025
Col8a2	-7493	-2433
Col9a2	7569	2976
Col9a3	3714	-1615

---

---

ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM

metric	value
setSize	10
pMANOVA	0.0121
p.adjustMANOVA	0.0523
s.dist	0.542
s.LPS	0.0136
s.OVA	0.542
p.LPS	0.94
p.OVA	0.00299

Top 20 genes

Gene	LPS	OVA
Got1	4368	6534
Naalad2	4078	5288
Folh1	2863	6635
Got2	2738	5946
Nat8l	1600	103

Click HERE to show all gene set members

All member genes

	LPS	OVA
Asns	-6224	7462
Aspa	-7661	4930
Aspg	4189	-5649
Folh1	2863	6635
Got1	4368	6534
Got2	2738	5946
Naalad2	4078	5288
Nat8l	1600	103
Slc25a12	-2950	4506
Slc25a13	-6598	7142

---

---

SHC MEDIATED CASCADE FGFR3

SHC MEDIATED CASCADE FGFR3

metric	value
setSize	12
pMANOVA	0.0066
p.adjustMANOVA	0.032
s.dist	0.541
s.LPS	0.214
s.OVA	0.497
p.LPS	0.198
p.OVA	0.0029

Top 20 genes

Gene	LPS	OVA
Fgfr3	7713	7853
Fgf1	3813	7424
Hras	4447	6110
Fgf9	3659	4354
Fgf2	2651	5894
Shc1	7110	2123
Fgf18	620	3640

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgf1	3813	7424
Fgf18	620	3640
Fgf2	2651	5894
Fgf5	5693	-1711
Fgf9	3659	4354
Fgfr3	7713	7853
Grb2	-3203	1149
Hras	4447	6110
Kras	-6543	5579
Nras	-4446	3851
Shc1	7110	2123
Sos1	-5907	674

---

---

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

metric	value
setSize	29
pMANOVA	1.52e-06
p.adjustMANOVA	3.63e-05
s.dist	0.54
s.LPS	-0.216
s.OVA	0.495
p.LPS	0.0442
p.OVA	3.9e-06

Top 20 genes

Gene	LPS	OVA
Ube2d1	-7897	5949
Ube2d2a	-7238	6097
Ube2l3	-5959	7066
Ube2a	-6093	6498
Ube2w	-7199	5275
Ube2g1	-4772	7663
Usp9x	-7115	4817
Ube2b	-6419	5229
Ube2e3	-5540	5773
Ube2q2	-5143	5291
Uchl3	-7805	3234
Ube2e1	-3586	5385
Uba6	-3042	4651
Ube2k	-5377	2126
Ube2z	-2081	4150
Ube2r2	-1047	7975
Ube2h	-1763	2601
Cdc34	-124	3642

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cdc34	-124	3642
Otulin	1050	5520
Rps27a	5721	6253
Uba1	1005	319
Uba52	3801	4656
Uba6	-3042	4651
Ubb	2566	4439
Ubc	3034	-673
Ube2a	-6093	6498
Ube2b	-6419	5229
Ube2d1	-7897	5949
Ube2d2a	-7238	6097
Ube2e1	-3586	5385
Ube2e3	-5540	5773
Ube2g1	-4772	7663
Ube2g2	-128	-1818
Ube2h	-1763	2601
Ube2k	-5377	2126
Ube2l3	-5959	7066
Ube2q2	-5143	5291
Ube2r2	-1047	7975
Ube2s	23	837
Ube2t	4163	-677
Ube2w	-7199	5275
Ube2z	-2081	4150
Uchl3	-7805	3234
Usp5	2410	2438
Usp7	-882	-1717
Usp9x	-7115	4817

---

---

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

metric	value
setSize	20
pMANOVA	0.000177
p.adjustMANOVA	0.00172
s.dist	0.535
s.LPS	-0.00703
s.OVA	0.535
p.LPS	0.957
p.OVA	3.43e-05

Top 20 genes

Gene	LPS	OVA
Elovl4	-7080	6818
Acsl4	-6764	5738
Acsl3	-3920	7498
Elovl7	-7998	3624
Hacd2	-3847	7159
Acsl1	-4198	4259
Elovl2	-895	5553
Hsd17b12	-297	7821

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acsbg1	7214	7513
Acsf3	-2701	-5397
Acsl1	-4198	4259
Acsl3	-3920	7498
Acsl4	-6764	5738
Acsl5	-5012	-954
Acsl6	433	3607
Elovl1	7795	8073
Elovl2	-895	5553
Elovl4	-7080	6818
Elovl5	403	7730
Elovl6	3612	1433
Elovl7	-7998	3624
Hacd1	2225	7375
Hacd2	-3847	7159
Hacd3	3734	7725
Hacd4	-3161	-252
Hsd17b12	-297	7821
Slc27a3	2678	-5073
Tecr	7167	4308

---

---

SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM

metric	value
setSize	107
pMANOVA	2.87e-19
p.adjustMANOVA	2.78e-17
s.dist	0.534
s.LPS	0.332
s.OVA	0.418
p.LPS	3.09e-09
p.OVA	7.55e-14

Top 20 genes

Gene	LPS	OVA
Ahcy	7507	7405
Rps8	7269	7309
Rpl23a	6015	7526
Rps9	5470	7584
Rps29	6454	5764
Rps4x	5413	6683
Rps27a	5721	6253
Rpl23	5508	6486
Rpl6	5265	6716
Rps27l	4686	7434
Rpl37a	5424	6156
Rps25	4264	7814
Rpl24	4398	7497
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300
Rpl26	7183	3616
Rpl35	6121	4242

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ahcy	7507	7405
Aimp1	1355	4825
Aimp2	6142	268
Cbs	2626	-568
Cth	-1307	6923
Dars	-7224	5278
Eef1e1	-1249	7098
Eefsec	40	-1800
Eprs	2558	863
Fau	3642	5713
Gsr	-3324	5238
Hnmt	-7289	7637
Iars	3348	-5243
Kars	-281	7920
Lars	-1610	-5960
Mars1	6048	-6552
Papss1	1035	6823
Papss2	-5682	5110
Pstk	-3535	-5964
Qars	-3239	1323
Rars	-2988	1479
Rpl10	3681	-3707
Rpl10a	887	725
Rpl11	2278	5271
Rpl12	3715	-7459
Rpl13	3904	3220
Rpl13a	405	6090
Rpl14	3947	5501
Rpl15	-3300	3005
Rpl17	-2674	5569
Rpl18	1839	261
Rpl18a	3851	5321
Rpl19	2619	3550
Rpl21	2971	2664
Rpl22	727	5843
Rpl22l1	-3342	6907
Rpl23	5508	6486
Rpl23a	6015	7526
Rpl24	4398	7497
Rpl26	7183	3616
Rpl27	526	5180
Rpl27a	2840	2777
Rpl28	6951	830
Rpl29	-308	3645
Rpl3	2605	5902
Rpl30	3372	5167
Rpl31	3208	5659
Rpl32	3941	4603
Rpl34	-368	3497
Rpl35	6121	4242
Rpl35a	4654	5451
Rpl36	2400	-378
Rpl36a	919	4018
Rpl36al	2700	1803
Rpl37	5410	2939
Rpl37a	5424	6156
Rpl38	6478	3980
Rpl39	-2409	4847
Rpl4	866	6114
Rpl5	1278	6005
Rpl6	5265	6716
Rpl7	-1345	4991
Rpl7a	4402	2277
Rpl8	5073	2661
Rpl9	1473	5111
Rplp0	-305	5857
Rplp1	4410	-555
Rplp2	6464	772
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098
Sars	6473	110
Scly	906	-3430
Secisbp2	5871	-6789
Sephs2	-7561	3363
Sepsecs	-6555	-5667
Txnrd1	-3548	610
Uba52	3801	4656

---

---

SIGNALING BY FGFR3 FUSIONS IN CANCER

SIGNALING BY FGFR3 FUSIONS IN CANCER

metric	value
setSize	10
pMANOVA	0.0113
p.adjustMANOVA	0.0497
s.dist	0.534
s.LPS	-0.187
s.OVA	0.5
p.LPS	0.306
p.OVA	0.00619

Top 20 genes

Gene	LPS	OVA
Kras	-6543	5579
Gab1	-4803	7454
Frs2	-6071	4412
Nras	-4446	3851
Sos1	-5907	674
Grb2	-3203	1149

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgfr3	7713	7853
Frs2	-6071	4412
Gab1	-4803	7454
Grb2	-3203	1149
Hras	4447	6110
Kras	-6543	5579
Nras	-4446	3851
Pik3ca	1378	6244
Pik3r1	-2748	-3930
Sos1	-5907	674

---

---

SCAVENGING BY CLASS A RECEPTORS

SCAVENGING BY CLASS A RECEPTORS

metric	value
setSize	13
pMANOVA	0.00554
p.adjustMANOVA	0.0275
s.dist	0.532
s.LPS	0.446
s.OVA	0.291
p.LPS	0.0054
p.OVA	0.0691

Top 20 genes

Gene	LPS	OVA
Calr	7700	7865
Colec12	7152	7767
Col1a2	7309	5847
Apoe	5886	6055
Masp1	2774	7044
Hsp90b1	2500	6284
Col3a1	5848	1993
Ftl1	1716	4538

Click HERE to show all gene set members

All member genes

	LPS	OVA
Apoe	5886	6055
Calr	7700	7865
Col1a1	2552	-6406
Col1a2	7309	5847
Col3a1	5848	1993
Col4a1	-836	-8183
Col4a2	5545	-8019
Colec12	7152	7767
Fth1	-274	6240
Ftl1	1716	4538
Hsp90b1	2500	6284
Masp1	2774	7044
Scara5	-6113	-2249

---

---

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

metric	value
setSize	11
pMANOVA	0.00863
p.adjustMANOVA	0.0398
s.dist	0.532
s.LPS	-0.53
s.OVA	0.0488
p.LPS	0.00234
p.OVA	0.779

Top 20 genes

Gene	LPS	OVA
Pik3c3	-6228	6553
Fig4	-4246	6474
Mtmr2	-7580	2591
Mtmr7	-5718	2935
Pik3c2a	-7898	293

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fig4	-4246	6474
Mtm1	392	-321
Mtmr2	-7580	2591
Mtmr4	-5564	-3684
Mtmr7	-5718	2935
Mtmr9	-5915	-2156
Pik3c2a	-7898	293
Pik3c3	-6228	6553
Pik3r4	-3270	-2475
Pikfyve	-8013	-6161
Vac14	635	-1753

---

---

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

metric	value
setSize	10
pMANOVA	0.0183
p.adjustMANOVA	0.0699
s.dist	0.53
s.LPS	0.231
s.OVA	0.477
p.LPS	0.206
p.OVA	0.00898

Top 20 genes

Gene	LPS	OVA
Calr	7700	7865
Nfyc	6347	6735
Hspa5	5094	7705
Ddit3	7454	4239
Xbp1	3568	7878
Hsp90b1	2500	6284

Click HERE to show all gene set members

All member genes

	LPS	OVA
Atf4	3752	-2098
Atf6	-7140	1162
Calr	7700	7865
Ddit3	7454	4239
Hsp90b1	2500	6284
Hspa5	5094	7705
Nfya	-6484	-7153
Nfyb	-8425	4900
Nfyc	6347	6735
Xbp1	3568	7878

---

---

ACTIVATION OF RAC1

ACTIVATION OF RAC1

metric	value
setSize	13
pMANOVA	0.0032
p.adjustMANOVA	0.0184
s.dist	0.53
s.LPS	-0.496
s.OVA	0.185
p.LPS	0.00195
p.OVA	0.247

Top 20 genes

Gene	LPS	OVA
Rac1	-7036	7670
Pak1	-7207	4464
Sos2	-6231	4047
Pak5	-5207	3531
Pak2	-2249	7894
Pak3	-3652	4264
Robo1	-7094	1594
Sos1	-5907	674
Nck1	-524	4851

Click HERE to show all gene set members

All member genes

	LPS	OVA
Nck1	-524	4851
Nck2	-1091	-3949
Pak1	-7207	4464
Pak2	-2249	7894
Pak3	-3652	4264
Pak4	-1892	-2843
Pak5	-5207	3531
Pak6	-2699	-7845
Rac1	-7036	7670
Robo1	-7094	1594
Slit2	-8699	-6961
Sos1	-5907	674
Sos2	-6231	4047

---

---

TRIGLYCERIDE CATABOLISM

TRIGLYCERIDE CATABOLISM

metric	value
setSize	14
pMANOVA	0.00255
p.adjustMANOVA	0.0154
s.dist	0.529
s.LPS	-0.0521
s.OVA	0.526
p.LPS	0.736
p.OVA	0.000655

Top 20 genes

Gene	LPS	OVA
Prkacb	-8480	6485
Ppp1cb	-5958	6601
Abhd5	-4555	6976
Gpd2	-7538	3428
Mgll	-3056	868
Ppp1ca	-155	4186

Click HERE to show all gene set members

All member genes

	LPS	OVA
Abhd5	-4555	6976
Cav1	4231	7990
Fabp3	1086	1580
Fabp5	5922	6214
Fabp7	-7505	-5723
Gpd2	-7538	3428
Lipe	3390	4695
Mgll	-3056	868
Plin3	6767	7826
Ppp1ca	-155	4186
Ppp1cb	-5958	6601
Ppp1cc	1454	7034
Prkaca	1753	1
Prkacb	-8480	6485

---

---

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

metric	value
setSize	15
pMANOVA	0.00265
p.adjustMANOVA	0.0159
s.dist	0.525
s.LPS	0.198
s.OVA	0.487
p.LPS	0.185
p.OVA	0.0011

Top 20 genes

Gene	LPS	OVA
Hif3a	7456	6469
Sall1	6659	6320
Klf4	6480	5941
Hhex	5761	6581
Epas1	6948	3971
Sox2	3257	7702
Stat3	6305	3857
Fgf2	2651	5894
Smad4	1312	6946

Click HERE to show all gene set members

All member genes

	LPS	OVA
Epas1	6948	3971
Fgf2	2651	5894
Foxp1	-3594	2369
Hhex	5761	6581
Hif3a	7456	6469
Klf4	6480	5941
Nr6a1	-2712	-5991
Pbx1	-2581	577
Sall1	6659	6320
Smad2	-7381	3104
Smad4	1312	6946
Sox2	3257	7702
Stat3	6305	3857
Tsc22d1	-7050	3274
Zic3	-6059	415

---

---

PI 3K CASCADE FGFR3

PI 3K CASCADE FGFR3

metric	value
setSize	12
pMANOVA	0.0086
p.adjustMANOVA	0.0398
s.dist	0.525
s.LPS	0.188
s.OVA	0.491
p.LPS	0.26
p.OVA	0.00326

Top 20 genes

Gene	LPS	OVA
Fgfr3	7713	7853
Fgf1	3813	7424
Fgf9	3659	4354
Fgf2	2651	5894
Ptpn11	4272	3559
Pik3ca	1378	6244
Fgf18	620	3640

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgf1	3813	7424
Fgf18	620	3640
Fgf2	2651	5894
Fgf5	5693	-1711
Fgf9	3659	4354
Fgfr3	7713	7853
Frs2	-6071	4412
Gab1	-4803	7454
Grb2	-3203	1149
Pik3ca	1378	6244
Pik3r1	-2748	-3930
Ptpn11	4272	3559

---

---

SHC MEDIATED CASCADE FGFR4

SHC MEDIATED CASCADE FGFR4

metric	value
setSize	10
pMANOVA	0.0176
p.adjustMANOVA	0.0684
s.dist	0.524
s.LPS	0.0837
s.OVA	0.517
p.LPS	0.647
p.OVA	0.00465

Top 20 genes

Gene	LPS	OVA
Fgf1	3813	7424
Hras	4447	6110
Fgf9	3659	4354
Fgf2	2651	5894
Shc1	7110	2123
Fgf18	620	3640

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgf1	3813	7424
Fgf18	620	3640
Fgf2	2651	5894
Fgf9	3659	4354
Grb2	-3203	1149
Hras	4447	6110
Kras	-6543	5579
Nras	-4446	3851
Shc1	7110	2123
Sos1	-5907	674

---

---

FRS MEDIATED FGFR3 SIGNALING

FRS MEDIATED FGFR3 SIGNALING

metric	value
setSize	14
pMANOVA	0.00389
p.adjustMANOVA	0.0215
s.dist	0.523
s.LPS	0.151
s.OVA	0.501
p.LPS	0.327
p.OVA	0.00118

Top 20 genes

Gene	LPS	OVA
Fgfr3	7713	7853
Fgf1	3813	7424
Hras	4447	6110
Fgf9	3659	4354
Fgf2	2651	5894
Ptpn11	4272	3559
Frs3	4211	2456
Fgf18	620	3640

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgf1	3813	7424
Fgf18	620	3640
Fgf2	2651	5894
Fgf5	5693	-1711
Fgf9	3659	4354
Fgfr3	7713	7853
Frs2	-6071	4412
Frs3	4211	2456
Grb2	-3203	1149
Hras	4447	6110
Kras	-6543	5579
Nras	-4446	3851
Ptpn11	4272	3559
Sos1	-5907	674

---

---

COMPLEMENT CASCADE

COMPLEMENT CASCADE

metric	value
setSize	22
pMANOVA	0.000231
p.adjustMANOVA	0.00217
s.dist	0.521
s.LPS	0.344
s.OVA	0.391
p.LPS	0.00524
p.OVA	0.00148

Top 20 genes

Gene	LPS	OVA
C1qb	6799	7122
C2	7641	5519
Serping1	6697	6016
C1qc	4296	7483
Clu	4694	6250
C1qa	2948	7430
Cfh	2523	7997
Masp1	2774	7044
C4b	4806	3711
Cr1l	1896	4805
Pros1	1017	7565
Cd81	862	7404
Cd55	761	4841

Click HERE to show all gene set members

All member genes

	LPS	OVA
C1qa	2948	7430
C1qb	6799	7122
C1qc	4296	7483
C2	7641	5519
C3ar1	-2324	5338
C4b	4806	3711
C8g	2961	-6233
Cd46	4159	-2940
Cd55	761	4841
Cd59b	-1250	-2386
Cd81	862	7404
Cfb	-7654	-6022
Cfh	2523	7997
Cfp	7564	-1864
Clu	4694	6250
Cr1l	1896	4805
Gzmm	-541	-2227
Masp1	2774	7044
Masp2	5858	-2258
Pros1	1017	7565
Serping1	6697	6016
Vtn	-4358	2287

---

---

FRS MEDIATED FGFR4 SIGNALING

FRS MEDIATED FGFR4 SIGNALING

metric	value
setSize	12
pMANOVA	0.00796
p.adjustMANOVA	0.0374
s.dist	0.519
s.LPS	0.032
s.OVA	0.518
p.LPS	0.848
p.OVA	0.00188

Top 20 genes

Gene	LPS	OVA
Fgf1	3813	7424
Hras	4447	6110
Fgf9	3659	4354
Fgf2	2651	5894
Ptpn11	4272	3559
Frs3	4211	2456
Fgf18	620	3640

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgf1	3813	7424
Fgf18	620	3640
Fgf2	2651	5894
Fgf9	3659	4354
Frs2	-6071	4412
Frs3	4211	2456
Grb2	-3203	1149
Hras	4447	6110
Kras	-6543	5579
Nras	-4446	3851
Ptpn11	4272	3559
Sos1	-5907	674

---

---

CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE

metric	value
setSize	22
pMANOVA	0.000167
p.adjustMANOVA	0.00169
s.dist	0.519
s.LPS	0.0952
s.OVA	0.51
p.LPS	0.44
p.OVA	3.43e-05

Top 20 genes

Gene	LPS	OVA
Idh2	7463	6233
Suclg2	3744	7028
Suclg1	3076	5281
Nnt	2362	6529
Ogdh	2803	3777
Aco2	1817	4188
Fahd1	3260	1561
Mdh2	1031	3677
Sdhc	266	7696

Click HERE to show all gene set members

All member genes

	LPS	OVA
Aco2	1817	4188
Cs	-3349	4952
Dld	-7038	4578
Dlst	7422	-352
Fahd1	3260	1561
Fh1	-3924	5147
Idh2	7463	6233
Idh3a	-3029	7845
Idh3b	-152	-2449
Idh3g	3631	-2170
Mdh2	1031	3677
Me2	-3929	3443
Me3	-2878	55
Nnt	2362	6529
Ogdh	2803	3777
Sdha	-195	5190
Sdhb	-706	4437
Sdhc	266	7696
Sdhd	-1586	4980
Sucla2	-3182	6857
Suclg1	3076	5281
Suclg2	3744	7028

---

---

CRMPS IN SEMA3A SIGNALING

CRMPS IN SEMA3A SIGNALING

metric	value
setSize	16
pMANOVA	0.00182
p.adjustMANOVA	0.0117
s.dist	0.517
s.LPS	-0.0766
s.OVA	-0.511
p.LPS	0.596
p.OVA	0.000399

Top 20 genes

Gene	LPS	OVA
Plxna4	-4981	-7926
Crmp1	-4700	-6300
Cdk5r1	-8262	-2363
Plxna1	-1783	-7425
Plxna2	-2660	-4386
Gsk3b	-5884	-1837
Nrp1	-1539	-3875

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cdk5	3038	-4307
Cdk5r1	-8262	-2363
Crmp1	-4700	-6300
Dpysl2	1167	-7144
Dpysl3	585	-5916
Dpysl4	3567	-6188
Dpysl5	2267	-5609
Fes	4946	-724
Fyn	-3965	235
Gsk3b	-5884	-1837
Nrp1	-1539	-3875
Plxna1	-1783	-7425
Plxna2	-2660	-4386
Plxna3	6888	-7836
Plxna4	-4981	-7926
Sema3a	-6381	870

---

---

NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD

metric	value
setSize	109
pMANOVA	4.07e-18
p.adjustMANOVA	3.39e-16
s.dist	0.513
s.LPS	0.353
s.OVA	0.372
p.LPS	2.01e-10
p.OVA	1.88e-11

Top 20 genes

Gene	LPS	OVA
Rps8	7269	7309
Rpl23a	6015	7526
Rps9	5470	7584
Rbm8a	5181	7524
Rps29	6454	5764
Rps4x	5413	6683
Rps27a	5721	6253
Rpl23	5508	6486
Rpl6	5265	6716
Rps27l	4686	7434
Rpl37a	5424	6156
Rps25	4264	7814
Rpl24	4398	7497
Rps3a1	4131	7050
Rps28	7413	3877
Rps26	5411	5204
Rps18	5147	5463
Rps19	5284	5300
Rpl26	7183	3616
Rpl35	6121	4242

Click HERE to show all gene set members

All member genes

	LPS	OVA
Casc3	5006	-8124
Dcp1a	-2682	-3375
Eif4a3	4667	4491
Eif4g1	5626	-6388
Etf1	-6353	5115
Fau	3642	5713
Gspt1	-5185	4874
Gspt2	1399	-2982
Magoh	-2101	-2345
Magohb	3204	4725
Ncbp1	627	4292
Ncbp2	1684	-2073
Pabpc1	-1115	6437
Pnrc2	-7671	6686
Ppp2ca	-2506	5974
Ppp2r1a	137	5751
Ppp2r2a	-4836	7646
Rbm8a	5181	7524
Rnps1	1850	1663
Rpl10	3681	-3707
Rpl10a	887	725
Rpl11	2278	5271
Rpl12	3715	-7459
Rpl13	3904	3220
Rpl13a	405	6090
Rpl14	3947	5501
Rpl15	-3300	3005
Rpl17	-2674	5569
Rpl18	1839	261
Rpl18a	3851	5321
Rpl19	2619	3550
Rpl21	2971	2664
Rpl22	727	5843
Rpl22l1	-3342	6907
Rpl23	5508	6486
Rpl23a	6015	7526
Rpl24	4398	7497
Rpl26	7183	3616
Rpl27	526	5180
Rpl27a	2840	2777
Rpl28	6951	830
Rpl29	-308	3645
Rpl3	2605	5902
Rpl30	3372	5167
Rpl31	3208	5659
Rpl32	3941	4603
Rpl34	-368	3497
Rpl35	6121	4242
Rpl35a	4654	5451
Rpl36	2400	-378
Rpl36a	919	4018
Rpl36al	2700	1803
Rpl37	5410	2939
Rpl37a	5424	6156
Rpl38	6478	3980
Rpl39	-2409	4847
Rpl4	866	6114
Rpl5	1278	6005
Rpl6	5265	6716
Rpl7	-1345	4991
Rpl7a	4402	2277
Rpl8	5073	2661
Rpl9	1473	5111
Rplp0	-305	5857
Rplp1	4410	-555
Rplp2	6464	772
Rps10	2927	1096
Rps11	3856	3501
Rps12	1202	-529
Rps13	5831	2141
Rps14	3092	-1425
Rps15	2974	681
Rps15a	-1928	-367
Rps16	3363	1896
Rps17	3862	2720
Rps18	5147	5463
Rps19	5284	5300
Rps2	5568	1407
Rps20	-237	5390
Rps21	5587	3173
Rps23	865	6778
Rps24	3022	6357
Rps25	4264	7814
Rps26	5411	5204
Rps27	1642	2194
Rps27a	5721	6253
Rps27l	4686	7434
Rps28	7413	3877
Rps29	6454	5764
Rps3	-767	1372
Rps3a1	4131	7050
Rps4x	5413	6683
Rps5	2207	4922
Rps6	3673	2037
Rps7	2681	6267
Rps8	7269	7309
Rps9	5470	7584
Rpsa	2565	3098
Smg1	-2419	-8045
Smg5	2158	-6468
Smg6	-4231	-8330
Smg7	-3525	-5976
Smg8	-2111	3842
Smg9	1677	-4675
Uba52	3801	4656
Upf1	4553	-7635
Upf2	5788	-5907
Upf3a	7289	-3312
Upf3b	5678	2082

---

---

PI 3K CASCADE FGFR4

PI 3K CASCADE FGFR4

metric	value
setSize	10
pMANOVA	0.0203
p.adjustMANOVA	0.0751
s.dist	0.512
s.LPS	0.0519
s.OVA	0.51
p.LPS	0.776
p.OVA	0.00526

Top 20 genes

Gene	LPS	OVA
Fgf1	3813	7424
Fgf9	3659	4354
Fgf2	2651	5894
Ptpn11	4272	3559
Pik3ca	1378	6244
Fgf18	620	3640

Click HERE to show all gene set members

All member genes

	LPS	OVA
Fgf1	3813	7424
Fgf18	620	3640
Fgf2	2651	5894
Fgf9	3659	4354
Frs2	-6071	4412
Gab1	-4803	7454
Grb2	-3203	1149
Pik3ca	1378	6244
Pik3r1	-2748	-3930
Ptpn11	4272	3559

---

---

BLOOD GROUP SYSTEMS BIOSYNTHESIS

BLOOD GROUP SYSTEMS BIOSYNTHESIS

metric	value
setSize	13
pMANOVA	0.00516
p.adjustMANOVA	0.0264
s.dist	0.51
s.LPS	-0.125
s.OVA	0.495
p.LPS	0.435
p.OVA	0.00201

Top 20 genes

Gene	LPS	OVA
B3galt1	-7820	5264
Fut9	-7504	5205
B3galt2	-5774	6434
B3galt5	-4695	6492
St3gal6	-1938	5356
Fut10	-1390	3959
Fut2	-1200	2104
St6galnac6	-701	3135

Click HERE to show all gene set members

All member genes

	LPS	OVA
B3galt1	-7820	5264
B3galt2	-5774	6434
B3galt4	-8291	-1976
B3galt5	-4695	6492
Fut10	-1390	3959
Fut11	6253	4650
Fut2	-1200	2104
Fut4	544	838
Fut9	-7504	5205
St3gal3	6212	1136
St3gal4	6713	8048
St3gal6	-1938	5356
St6galnac6	-701	3135

---

---

G BETA GAMMA SIGNALLING THROUGH CDC42

G BETA GAMMA SIGNALLING THROUGH CDC42

metric	value
setSize	18
pMANOVA	0.000593
p.adjustMANOVA	0.0047
s.dist	0.51
s.LPS	-0.223
s.OVA	0.459
p.LPS	0.102
p.OVA	0.000754

Top 20 genes

Gene	LPS	OVA
Gng12	-6342	7762
Cdc42	-6734	6326
Gng10	-5606	7084
Pak1	-7207	4464
Gnb4	-8083	2628
Gng2	-8001	1552
Gng5	-818	7006
Gnb1	-6678	592
Gng13	-3686	918
Gng11	-360	6592
Gng7	-405	5101
Gnb2	-173	1359

Click HERE to show all gene set members

All member genes

	LPS	OVA
Arhgef6	-5440	-4409
Cdc42	-6734	6326
Gnb1	-6678	592
Gnb2	-173	1359
Gnb4	-8083	2628
Gnb5	2322	6656
Gng10	-5606	7084
Gng11	-360	6592
Gng12	-6342	7762
Gng13	-3686	918
Gng2	-8001	1552
Gng3	4649	4211
Gng4	688	2010
Gng5	-818	7006
Gng7	-405	5101
Gng8	5762	2068
Gngt2	4501	2828
Pak1	-7207	4464

---

---

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

metric	value
setSize	18
pMANOVA	0.00118
p.adjustMANOVA	0.00837
s.dist	0.509
s.LPS	0.157
s.OVA	0.484
p.LPS	0.249
p.OVA	0.000373

Top 20 genes

Gene	LPS	OVA
Atp5b	2777	7881
Atp5o	3993	3961
Atp5j	4104	3760
Atp5g3	3186	4173
Atp5h	1671	6021
Atp5d	3989	1763
mt-Atp8	994	6358
Atp5g1	5849	1062
Atp5j2	4355	1374
Atp5k	7163	360
Atp5e	1649	1321

Click HERE to show all gene set members

All member genes

	LPS	OVA
Atp5a1	-4979	7815
Atp5b	2777	7881
Atp5c1	-5844	7552
Atp5d	3989	1763
Atp5e	1649	1321
Atp5g1	5849	1062
Atp5g2	-6493	-3010
Atp5g3	3186	4173
Atp5h	1671	6021
Atp5j	4104	3760
Atp5j2	4355	1374
Atp5k	7163	360
Atp5l	-831	1707
Atp5o	3993	3961
Atp5pb	-1235	7179
Dmac2l	-2606	2799
mt-Atp6	-2868	6502
mt-Atp8	994	6358

---

---

PLATELET SENSITIZATION BY LDL

PLATELET SENSITIZATION BY LDL

metric	value
setSize	15
pMANOVA	0.00341
p.adjustMANOVA	0.0192
s.dist	0.505
s.LPS	0.0548
s.OVA	0.502
p.LPS	0.713
p.OVA	0.000757

Top 20 genes

Gene	LPS	OVA
Ppp2r5b	7586	7671
Ptpn6	7460	5262
Ppp2r5d	5356	6041
Ptpn11	4272	3559
Pla2g4a	2008	7127
Ppp2r1a	137	5751

Click HERE to show all gene set members

All member genes

	LPS	OVA
Lrp8	-934	-8372
Mapk14	2007	-4067
Pecam1	-7440	6257
Pla2g4a	2008	7127
Ppp2ca	-2506	5974
Ppp2cb	-7982	7855
Ppp2r1a	137	5751
Ppp2r1b	-932	-3510
Ppp2r5a	-1874	7783
Ppp2r5b	7586	7671
Ppp2r5c	-5782	6187
Ppp2r5d	5356	6041
Ppp2r5e	-1666	5852
Ptpn11	4272	3559
Ptpn6	7460	5262

---

---

RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE

metric	value
setSize	10
pMANOVA	0.0187
p.adjustMANOVA	0.0705
s.dist	0.505
s.LPS	-0.141
s.OVA	0.485
p.LPS	0.44
p.OVA	0.00795

Top 20 genes

Gene	LPS	OVA
Rhobtb3	-7960	7460
Cul3	-7372	7408
Vhl	-7890	5202
Rab9b	-3608	4709
Lrrc41	-5186	2725
Rab9	-478	6856

Click HERE to show all gene set members

All member genes

	LPS	OVA
Ccne1	2893	-6901
Cul3	-7372	7408
Hgs	4706	611
Htr7	1747	2243
Lrrc41	-5186	2725
Plin3	6767	7826
Rab9	-478	6856
Rab9b	-3608	4709
Rhobtb3	-7960	7460
Vhl	-7890	5202

---

---

GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES

metric	value
setSize	12
pMANOVA	0.0158
p.adjustMANOVA	0.0632
s.dist	0.491
s.LPS	0.186
s.OVA	0.455
p.LPS	0.266
p.OVA	0.00637

Top 20 genes

Gene	LPS	OVA
Rps27a	5721	6253
Gys1	7521	3079
Uba52	3801	4656
Nhlrc1	2572	4999
Ubb	2566	4439
Gaa	452	3597
Ppp1r3c	175	4961

Click HERE to show all gene set members

All member genes

	LPS	OVA
Epm2a	-8649	-6605
G6pc3	-100	3447
Gaa	452	3597
Gbe1	-3440	7407
Gyg	-912	7240
Gys1	7521	3079
Nhlrc1	2572	4999
Ppp1r3c	175	4961
Rps27a	5721	6253
Uba52	3801	4656
Ubb	2566	4439
Ubc	3034	-673

---

---

SEROTONIN RECEPTORS

SEROTONIN RECEPTORS

metric	value
setSize	10
pMANOVA	0.0208
p.adjustMANOVA	0.0764
s.dist	0.491
s.LPS	-0.393
s.OVA	0.294
p.LPS	0.0313
p.OVA	0.107

Top 20 genes

Gene	LPS	OVA
Htr2a	-7122	6384
Htr2c	-6679	4036
Htr1d	-5039	3421
Htr1f	-2692	3773

Click HERE to show all gene set members

All member genes

	LPS	OVA
Htr1a	57	3366
Htr1b	1177	5911
Htr1d	-5039	3421
Htr1f	-2692	3773
Htr2a	-7122	6384
Htr2c	-6679	4036
Htr4	-8665	-2931
Htr5a	-7168	-1892
Htr6	-2860	-1931
Htr7	1747	2243

---

---

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

metric	value
setSize	172
pMANOVA	1.2e-26
p.adjustMANOVA	4.68e-24
s.dist	0.491
s.LPS	0.14
s.OVA	0.471
p.LPS	0.00159
p.OVA	1.72e-26

Top 20 genes

Gene	LPS	OVA
Timmdc1	7357	7319
Ndufa12	6998	7523
Idh2	7463	6233
Ndufa10	5715	7438
Ndufaf1	5653	7100
Ndufa13	6592	5812
Rxra	5738	6255
Ldhb	5971	5888
Ndufs2	4508	7474
Ndufaf2	4874	6154
Ndufaf6	4271	6561
Ndufs5	5914	4689
Sco2	4448	5969
Suclg2	3744	7028
Ucp2	3845	6673
Ndufa6	5352	4748
Taco1	5103	4947
Cox5b	4770	5257
Pm20d1	5121	4737
Surf1	3345	6962

Click HERE to show all gene set members

All member genes

	LPS	OVA
Acad9	608	1981
Aco2	1817	4188
Adhfe1	-4171	4446
Atp5a1	-4979	7815
Atp5b	2777	7881
Atp5c1	-5844	7552
Atp5d	3989	1763
Atp5e	1649	1321
Atp5g1	5849	1062
Atp5g2	-6493	-3010
Atp5g3	3186	4173
Atp5h	1671	6021
Atp5j	4104	3760
Atp5j2	4355	1374
Atp5k	7163	360
Atp5l	-831	1707
Atp5o	3993	3961
Atp5pb	-1235	7179
Bsg	-2241	3328
Coq10a	3815	5334
Coq10b	-3900	7972
Cox11	4944	-7059
Cox14	-791	-2266
Cox16	-5837	4702
Cox18	1918	4164
Cox19	6179	-4411
Cox20	494	5292
Cox4i1	2759	419
Cox5a	2967	7056
Cox5b	4770	5257
Cox6a1	533	6489
Cox6b1	3314	1740
Cox6c	1236	4892
Cox7a2l	1780	7722
Cox7b	367	4500
Cox7c	1266	5795
Cox8a	139	4534
Cs	-3349	4952
Cyc1	1431	2316
Cycs	-4448	7302
D2hgdh	-1034	-1142
Dlat	-460	7557
Dld	-7038	4578
Dlst	7422	-352
Dmac2l	-2606	2799
Ecsit	1595	2336
Etfa	-2755	3110
Etfb	-1009	1992
Etfdh	-5075	1102
Fahd1	3260	1561
Fh1	-3924	5147
Glo1	-64	6679
Gstz1	-1247	-4277
Hagh	3304	1620
Idh2	7463	6233
Idh3a	-3029	7845
Idh3b	-152	-2449
Idh3g	3631	-2170
L2hgdh	-3603	-1909
Ldha	-3157	-113
Ldhb	5971	5888
Lrpprc	-4802	-6897
Mdh2	1031	3677
Me1	-1764	5724
Me2	-3929	3443
Me3	-2878	55
Mpc1	-92	7173
Mpc2	-2652	5317
mt-Atp6	-2868	6502
mt-Atp8	994	6358
mt-Co1	-2709	7832
mt-Co2	-2570	7453
mt-Co3	-1213	7241
mt-Cytb	-1700	7368
mt-Nd1	-3437	7547
mt-Nd2	-4161	7398
mt-Nd3	-125	7652
mt-Nd4	-4483	7747
mt-Nd5	-4792	7472
mt-Nd6	-5972	7648
Ndufa1	4455	2808
Ndufa10	5715	7438
Ndufa11	2653	-920
Ndufa12	6998	7523
Ndufa13	6592	5812
Ndufa2	3298	-1358
Ndufa3	5066	-187
Ndufa4	647	6888
Ndufa5	1897	7071
Ndufa6	5352	4748
Ndufa7	1187	4511
Ndufa8	3953	1692
Ndufa9	214	-1151
Ndufab1	1653	5587
Ndufaf1	5653	7100
Ndufaf2	4874	6154
Ndufaf3	-710	-1141
Ndufaf4	-86	7830
Ndufaf5	2350	5651
Ndufaf6	4271	6561
Ndufaf7	952	-1197
Ndufb1	-3377	3408
Ndufb10	7581	314
Ndufb11	56	6442
Ndufb2	5312	1230
Ndufb3	6621	2486
Ndufb4	-1779	6522
Ndufb5	2197	7899
Ndufb6	2316	4162
Ndufb7	4405	1364
Ndufb8	3172	6153
Ndufb9	2239	6715
Ndufc1	575	7834
Ndufc2	-860	4791
Ndufs1	-1826	6346
Ndufs2	4508	7474
Ndufs3	-2761	5967
Ndufs4	2427	7475
Ndufs5	5914	4689
Ndufs6	5835	3821
Ndufs7	4329	2096
Ndufs8	2347	349
Ndufv1	5328	3456
Ndufv2	-2931	7852
Ndufv3	1927	201
Nnt	2362	6529
Nubpl	-4045	24
Ogdh	2803	3777
Pdha1	-458	7222
Pdhb	-1925	5112
Pdhx	-6801	4811
Pdk1	-5355	-8266
Pdk2	294	328
Pdk3	-3876	7928
Pdk4	-7648	5953
Pdp1	-670	5797
Pdp2	-7246	-6912
Pdpr	-3295	-2910
Pm20d1	5121	4737
Ppard	5742	3245
Rxra	5738	6255
Sco1	-8421	89
Sco2	4448	5969
Sdha	-195	5190
Sdhb	-706	4437
Sdhc	266	7696
Sdhd	-1586	4980
Slc16a1	-8745	4019
Slc16a3	-3570	-1969
Slc16a8	-8439	-7477
Slc25a14	475	6786
Slc25a27	7307	-6515
Sucla2	-3182	6857
Suclg1	3076	5281
Suclg2	3744	7028
Surf1	3345	6962
Taco1	5103	4947
Timmdc1	7357	7319
Tmem126b	7101	3219
Tmem186	333	-7228
Trap1	6956	-274
Ucp2	3845	6673
Ucp3	2554	3994
Uqcr10	2812	941
Uqcr11	2518	-883
Uqcrb	2530	7255
Uqcrc1	3152	822
Uqcrc2	-6454	5459
Uqcrfs1	-1373	3878
Uqcrh	1339	3287
Uqcrq	2765	4378
Vdac1	1584	5837

---

---

DARPP 32 EVENTS

DARPP 32 EVENTS

metric	value
setSize	23
pMANOVA	0.00017
p.adjustMANOVA	0.0017
s.dist	0.488
s.LPS	-0.201
s.OVA	0.445
p.LPS	0.0954
p.OVA	0.000222

Top 20 genes

Gene	LPS	OVA
Ppp2cb	-7982	7855
Prkar2b	-8282	6950
Prkacb	-8480	6485
Ppp3r1	-7651	6885
Ppp3cb	-7423	6481
Prkar1a	-7928	6048
Calm1	-6747	5510
Ppp3ca	-4157	6737
Pde4b	-4169	5571
Ppp2ca	-2506	5974
Prkar1b	-540	3037
Ppp1ca	-155	4186

Click HERE to show all gene set members

All member genes

	LPS	OVA
Calm1	-6747	5510
Cdk5	3038	-4307
Pde4a	5033	-424
Pde4b	-4169	5571
Pde4c	7631	787
Pde4d	-4825	-3792
Ppp1ca	-155	4186
Ppp1r1b	925	4989
Ppp2ca	-2506	5974
Ppp2cb	-7982	7855
Ppp2r1a	137	5751
Ppp2r1b	-932	-3510
Ppp2r5d	5356	6041
Ppp3ca	-4157	6737
Ppp3cb	-7423	6481
Ppp3cc	-5405	-3732
Ppp3r1	-7651	6885
Prkaca	1753	1
Prkacb	-8480	6485
Prkar1a	-7928	6048
Prkar1b	-540	3037
Prkar2a	4256	6537
Prkar2b	-8282	6950

---

---

ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON

ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON

metric	value
setSize	16
pMANOVA	0.00462
p.adjustMANOVA	0.0245
s.dist	0.486
s.LPS	0.437
s.OVA	0.212
p.LPS	0.00246
p.OVA	0.142

Top 20 genes

Gene	LPS	OVA
Cd14	6394	7711
Ticam2	6672	5844
Rps27a	5721	6253
Uba52	3801	4656
Tank	2704	6341
Tlr4	3818	4141
Ptpn11	4272	3559
Ticam1	4213	2893
Ubb	2566	4439
Ikbke	4860	1022

Click HERE to show all gene set members

All member genes

	LPS	OVA
Cd14	6394	7711
Ikbke	4860	1022
Irf3	7038	-2565
Irf7	-8747	1140
Ptpn11	4272	3559
Rps27a	5721	6253
Sarm1	-164	-6600
Tank	2704	6341
Tbk1	640	-6084
Ticam1	4213	2893
Ticam2	6672	5844
Tlr4	3818	4141
Traf3	3450	-7165
Uba52	3801	4656
Ubb	2566	4439
Ubc	3034	-673

---

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-55                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.3      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.1.3          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] prettyunits_1.1.1      colorspace_2.0-2       blob_1.2.2            
##  [22] rvest_1.0.2            haven_2.4.3            xfun_0.29             
##  [25] crayon_1.4.2           RCurl_1.98-1.6         jsonlite_1.7.3        
##  [28] genefilter_1.74.1      survival_3.2-13        glue_1.6.1            
##  [31] polyclip_1.10-0        gtable_0.3.0           zlibbioc_1.38.0       
##  [34] XVector_0.32.0         webshot_0.5.2          DelayedArray_0.18.0   
##  [37] scales_1.1.1           DBI_1.1.2              Rcpp_1.0.8            
##  [40] progress_1.2.2         viridisLite_0.4.0      xtable_1.8-4          
##  [43] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.2            
##  [46] RColorBrewer_1.1-2     ellipsis_0.3.2         farver_2.1.0          
##  [49] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.8          
##  [52] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.4        
##  [55] utf8_1.2.2             labeling_0.4.2         tidyselect_1.1.1      
##  [58] rlang_1.0.1            later_1.3.0            AnnotationDbi_1.54.1  
##  [61] munsell_0.5.0          cellranger_1.1.0       tools_4.1.3           
##  [64] cachem_1.0.6           cli_3.1.1              generics_0.1.2        
##  [67] RSQLite_2.2.9          broom_0.7.12           evaluate_0.14         
##  [70] fastmap_1.1.0          yaml_2.2.2             knitr_1.37            
##  [73] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [76] KEGGREST_1.32.0        mime_0.12              xml2_1.3.3            
##  [79] compiler_4.1.3         rstudioapi_0.13        png_0.1-7             
##  [82] reprex_2.0.1           geneplotter_1.70.0     bslib_0.3.1           
##  [85] stringi_1.7.6          highr_0.9              desc_1.4.0            
##  [88] lattice_0.20-45        Matrix_1.4-0           vctrs_0.3.8           
##  [91] pillar_1.7.0           lifecycle_1.0.1        jquerylib_0.1.4       
##  [94] data.table_1.14.2      bitops_1.0-7           httpuv_1.6.5          
##  [97] R6_2.5.1               promises_1.2.0.1       KernSmooth_2.23-20    
## [100] gridExtra_2.3          assertthat_0.2.1       rprojroot_2.0.2       
## [103] withr_2.4.3            GenomeInfoDbData_1.2.6 hms_1.1.1             
## [106] grid_4.1.3             rmarkdown_2.11         shiny_1.7.1           
## [109] lubridate_1.8.0

END of report