Mitch Report

date generated: 2022-03-15

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                         x
## 0610009B22Rik  0.02592933
## 0610009E02Rik  0.75195906
## 0610009L18Rik -1.06444668
## 0610010K14Rik  0.44760852
## 0610012G03Rik -0.16331991
## 0610030E20Rik -0.62496606

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	1604
num_genes_in_profile	17595
duplicated_genes_present	0
num_profile_genes_in_sets	8418
num_profile_genes_not_in_sets	9177

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	1604
num_genesets_excluded	426
num_genesets_included	1178

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	9.33e-08	0.707	5.50e-06
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.65e-04	0.608	4.00e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	5.67e-04	0.575	7.04e-03
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	7.89e-04	0.560	9.11e-03
RHOBTB3 ATPASE CYCLE	10	2.45e-03	0.553	2.10e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	8.36e-04	0.535	9.38e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	9.28e-06	0.534	2.80e-04
CITRIC ACID CYCLE TCA CYCLE	22	2.49e-05	0.519	6.36e-04
NUCLEOBASE BIOSYNTHESIS	15	6.68e-04	0.507	8.03e-03
KERATAN SULFATE BIOSYNTHESIS	24	2.54e-05	0.497	6.36e-04
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	1.48e-08	0.493	1.16e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	2.52e-05	0.477	6.36e-04
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	2.46e-08	0.465	1.70e-06
KERATAN SULFATE KERATIN METABOLISM	30	1.46e-05	0.457	4.09e-04
CALNEXIN CALRETICULIN CYCLE	26	5.90e-05	0.455	1.20e-03
GLYCOGEN STORAGE DISEASES	12	6.44e-03	0.454	4.24e-02
GAP JUNCTION ASSEMBLY	21	3.14e-04	0.454	4.62e-03
ENDOSOMAL VACUOLAR PATHWAY	10	1.31e-02	-0.453	6.81e-02
RETROGRADE NEUROTROPHIN SIGNALLING	13	4.77e-03	0.452	3.39e-02
GLYCOGEN SYNTHESIS	14	3.63e-03	0.449	2.74e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	2.65e-04	0.439	4.00e-03
LDL CLEARANCE	16	2.46e-03	0.437	2.10e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	1.69e-02	0.436	8.00e-02
OLFACTORY SIGNALING PATHWAY	40	2.56e-06	-0.430	1.12e-04
RHO GTPASES ACTIVATE IQGAPS	23	3.81e-04	0.428	5.21e-03
RECEPTOR MEDIATED MITOPHAGY	11	1.49e-02	0.424	7.49e-02
PURINE SALVAGE	12	1.14e-02	0.422	6.22e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	1.74e-05	0.420	4.75e-04
CD28 DEPENDENT VAV1 PATHWAY	11	1.64e-02	0.418	7.89e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	1.65e-02	0.417	7.89e-02
N GLYCAN ANTENNAE ELONGATION	15	5.19e-03	0.417	3.56e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	1.24e-02	0.417	6.54e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	9.63e-03	0.415	5.44e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	2.35e-02	0.414	1.00e-01
GLYCOGEN METABOLISM	25	3.53e-04	0.413	5.01e-03
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	8.18e-03	0.408	4.92e-02
CYTOSOLIC TRNA AMINOACYLATION	24	5.42e-04	0.408	6.94e-03
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	9.58e-04	0.407	1.05e-02
GLYCOSPHINGOLIPID METABOLISM	38	1.44e-05	0.407	4.09e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	1.61e-03	0.398	1.57e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	2.11e-03	0.397	1.91e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	1.08e-02	0.394	5.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION	12	1.83e-02	0.393	8.39e-02
CS DS DEGRADATION	14	1.24e-02	0.386	6.53e-02
IRE1ALPHA ACTIVATES CHAPERONES	50	2.69e-06	0.384	1.13e-04
KERATAN SULFATE DEGRADATION	11	2.84e-02	0.382	1.14e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	3.36e-03	0.379	2.62e-02
RECYCLING PATHWAY OF L1	40	3.41e-05	0.379	8.20e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	7.01e-03	0.378	4.49e-02
COPI MEDIATED ANTEROGRADE TRANSPORT	91	5.78e-10	0.376	5.23e-08

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	9.33e-08	7.07e-01	5.50e-06
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.65e-04	6.08e-01	4.00e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	5.67e-04	5.75e-01	7.04e-03
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	7.89e-04	5.60e-01	9.11e-03
RHOBTB3 ATPASE CYCLE	10	2.45e-03	5.53e-01	2.10e-02
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	8.36e-04	5.35e-01	9.38e-03
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	9.28e-06	5.34e-01	2.80e-04
CITRIC ACID CYCLE TCA CYCLE	22	2.49e-05	5.19e-01	6.36e-04
NUCLEOBASE BIOSYNTHESIS	15	6.68e-04	5.07e-01	8.03e-03
KERATAN SULFATE BIOSYNTHESIS	24	2.54e-05	4.97e-01	6.36e-04
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	1.48e-08	4.93e-01	1.16e-06
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	2.52e-05	4.77e-01	6.36e-04
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	2.46e-08	4.65e-01	1.70e-06
KERATAN SULFATE KERATIN METABOLISM	30	1.46e-05	4.57e-01	4.09e-04
CALNEXIN CALRETICULIN CYCLE	26	5.90e-05	4.55e-01	1.20e-03
GLYCOGEN STORAGE DISEASES	12	6.44e-03	4.54e-01	4.24e-02
GAP JUNCTION ASSEMBLY	21	3.14e-04	4.54e-01	4.62e-03
ENDOSOMAL VACUOLAR PATHWAY	10	1.31e-02	-4.53e-01	6.81e-02
RETROGRADE NEUROTROPHIN SIGNALLING	13	4.77e-03	4.52e-01	3.39e-02
GLYCOGEN SYNTHESIS	14	3.63e-03	4.49e-01	2.74e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	2.65e-04	4.39e-01	4.00e-03
LDL CLEARANCE	16	2.46e-03	4.37e-01	2.10e-02
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	1.69e-02	4.36e-01	8.00e-02
OLFACTORY SIGNALING PATHWAY	40	2.56e-06	-4.30e-01	1.12e-04
RHO GTPASES ACTIVATE IQGAPS	23	3.81e-04	4.28e-01	5.21e-03
RECEPTOR MEDIATED MITOPHAGY	11	1.49e-02	4.24e-01	7.49e-02
PURINE SALVAGE	12	1.14e-02	4.22e-01	6.22e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	1.74e-05	4.20e-01	4.75e-04
CD28 DEPENDENT VAV1 PATHWAY	11	1.64e-02	4.18e-01	7.89e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	1.65e-02	4.17e-01	7.89e-02
N GLYCAN ANTENNAE ELONGATION	15	5.19e-03	4.17e-01	3.56e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	1.24e-02	4.17e-01	6.54e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	9.63e-03	4.15e-01	5.44e-02
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	2.35e-02	4.14e-01	1.00e-01
GLYCOGEN METABOLISM	25	3.53e-04	4.13e-01	5.01e-03
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	8.18e-03	4.08e-01	4.92e-02
CYTOSOLIC TRNA AMINOACYLATION	24	5.42e-04	4.08e-01	6.94e-03
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	9.58e-04	4.07e-01	1.05e-02
GLYCOSPHINGOLIPID METABOLISM	38	1.44e-05	4.07e-01	4.09e-04
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	1.61e-03	3.98e-01	1.57e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	2.11e-03	3.97e-01	1.91e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	1.08e-02	3.94e-01	5.96e-02
SUPPRESSION OF PHAGOSOMAL MATURATION	12	1.83e-02	3.93e-01	8.39e-02
CS DS DEGRADATION	14	1.24e-02	3.86e-01	6.53e-02
IRE1ALPHA ACTIVATES CHAPERONES	50	2.69e-06	3.84e-01	1.13e-04
KERATAN SULFATE DEGRADATION	11	2.84e-02	3.82e-01	1.14e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	3.36e-03	3.79e-01	2.62e-02
RECYCLING PATHWAY OF L1	40	3.41e-05	3.79e-01	8.20e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	7.01e-03	3.78e-01	4.49e-02
COPI MEDIATED ANTEROGRADE TRANSPORT	91	5.78e-10	3.76e-01	5.23e-08
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	3.33e-02	3.71e-01	1.30e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	21	3.31e-03	3.70e-01	2.60e-02
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	7.34e-06	3.70e-01	2.34e-04
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	4.51e-02	3.66e-01	1.60e-01
INTERFERON ALPHA BETA SIGNALING	53	4.94e-06	-3.63e-01	1.71e-04
BRANCHED CHAIN AMINO ACID CATABOLISM	21	4.42e-03	3.59e-01	3.19e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	2.43e-03	3.57e-01	2.10e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	5.15e-02	3.56e-01	1.75e-01
KILLING MECHANISMS	11	4.23e-02	-3.54e-01	1.53e-01
VLDLR INTERNALISATION AND DEGRADATION	12	3.50e-02	3.52e-01	1.33e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	4.84e-04	3.51e-01	6.34e-03
ER QUALITY CONTROL COMPARTMENT ERQC	21	5.66e-03	3.49e-01	3.83e-02
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	1.99e-02	3.47e-01	8.86e-02
GOLGI TO ER RETROGRADE TRANSPORT	119	6.02e-11	3.47e-01	1.01e-08
INSULIN PROCESSING	24	3.26e-03	3.47e-01	2.59e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.26e-03	3.46e-01	1.31e-02
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	2.34e-04	3.45e-01	3.67e-03
FATTY ACYL COA BIOSYNTHESIS	32	7.84e-04	3.43e-01	9.11e-03
SULFUR AMINO ACID METABOLISM	23	4.78e-03	3.40e-01	3.39e-02
AGGREPHAGY	35	5.23e-04	3.39e-01	6.77e-03
GLUCONEOGENESIS	27	2.37e-03	3.38e-01	2.08e-02
HYALURONAN UPTAKE AND DEGRADATION	11	5.33e-02	3.36e-01	1.78e-01
NUCLEAR ENVELOPE NE REASSEMBLY	64	3.79e-06	3.34e-01	1.39e-04
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	1.90e-03	3.33e-01	1.77e-02
DERMATAN SULFATE BIOSYNTHESIS	11	5.65e-02	3.32e-01	1.87e-01
INTRAFLAGELLAR TRANSPORT	52	3.49e-05	3.32e-01	8.21e-04
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	4.93e-03	3.32e-01	3.43e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	5.11e-05	3.28e-01	1.08e-03
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	3.27e-03	3.27e-01	2.59e-02
INSULIN RECEPTOR RECYCLING	20	1.19e-02	3.25e-01	6.41e-02
HSF1 ACTIVATION	25	5.38e-03	3.22e-01	3.66e-02
SPRY REGULATION OF FGF SIGNALING	16	2.60e-02	3.22e-01	1.07e-01
GLUTAMATE AND GLUTAMINE METABOLISM	13	4.53e-02	3.21e-01	1.61e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	171	5.69e-13	3.20e-01	1.34e-10
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	5.54e-04	3.20e-01	7.02e-03
LYSOSOME VESICLE BIOGENESIS	33	1.53e-03	3.19e-01	1.52e-02
MATURATION OF NUCLEOPROTEIN	10	8.30e-02	-3.17e-01	2.42e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	17	2.42e-02	3.16e-01	1.02e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	3.47e-02	-3.15e-01	1.32e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	142	1.22e-10	3.13e-01	1.44e-08
PEROXISOMAL LIPID METABOLISM	27	4.92e-03	3.13e-01	3.43e-02
PROTEIN METHYLATION	17	2.56e-02	3.13e-01	1.06e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	5.85e-07	3.12e-01	3.00e-05
MHC CLASS II ANTIGEN PRESENTATION	102	5.62e-08	3.11e-01	3.48e-06
RAF ACTIVATION	34	1.69e-03	3.11e-01	1.63e-02
CTLA4 INHIBITORY SIGNALING	20	1.65e-02	3.10e-01	7.89e-02
RAP1 SIGNALLING	15	3.79e-02	3.10e-01	1.41e-01
TRNA AMINOACYLATION	42	5.63e-04	3.08e-01	7.04e-03
HSF1 DEPENDENT TRANSACTIVATION	33	2.39e-03	3.06e-01	2.08e-02
APOPTOSIS INDUCED DNA FRAGMENTATION	10	9.44e-02	-3.05e-01	2.67e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	3.46e-02	-3.05e-01	1.32e-01
ASPARTATE AND ASPARAGINE METABOLISM	10	9.79e-02	3.02e-01	2.72e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	4.24e-03	3.02e-01	3.08e-02
SPHINGOLIPID METABOLISM	80	3.33e-06	3.01e-01	1.27e-04
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	6.12e-02	3.00e-01	1.96e-01
SELECTIVE AUTOPHAGY	72	1.10e-05	3.00e-01	3.24e-04
EPHRIN SIGNALING	19	2.41e-02	2.99e-01	1.02e-01
DARPP 32 EVENTS	23	1.32e-02	2.99e-01	6.82e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	8.66e-02	-2.98e-01	2.49e-01
CARGO CONCENTRATION IN THE ER	31	4.21e-03	2.97e-01	3.08e-02
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	6.65e-02	2.94e-01	2.08e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	9.15e-02	2.94e-01	2.60e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	27	8.69e-03	2.92e-01	5.11e-02
ASPARAGINE N LINKED GLYCOSYLATION	285	2.66e-17	2.91e-01	1.57e-14
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	6.91e-02	2.91e-01	2.14e-01
PEROXISOMAL PROTEIN IMPORT	59	1.12e-04	2.91e-01	2.07e-03
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	25	1.21e-02	-2.90e-01	6.47e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	2.52e-02	2.89e-01	1.05e-01
HDMS DEMETHYLATE HISTONES	30	6.22e-03	-2.89e-01	4.17e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	36	2.75e-03	2.88e-01	2.28e-02
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	29	7.83e-03	-2.85e-01	4.81e-02
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	14	6.46e-02	2.85e-01	2.02e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	3.14e-02	2.85e-01	1.24e-01
IRON UPTAKE AND TRANSPORT	51	4.52e-04	2.84e-01	5.99e-03
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	5.73e-02	2.84e-01	1.88e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	1.71e-04	2.83e-01	2.93e-03
AUTOPHAGY	139	9.74e-09	2.82e-01	8.20e-07
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	36	3.56e-03	2.81e-01	2.73e-02
ACYL CHAIN REMODELLING OF PE	17	4.78e-02	2.77e-01	1.66e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	16	5.49e-02	2.77e-01	1.83e-01
INTERFERON GAMMA SIGNALING	74	3.78e-05	-2.77e-01	8.73e-04
RAB GERANYLGERANYLATION	57	3.61e-04	2.73e-01	5.07e-03
PKMTS METHYLATE HISTONE LYSINES	51	7.53e-04	-2.73e-01	8.87e-03
LYSINE CATABOLISM	11	1.18e-01	2.72e-01	3.08e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	13	8.98e-02	2.72e-01	2.57e-01
RESOLUTION OF D LOOP STRUCTURES	31	9.15e-03	-2.71e-01	5.23e-02
CHOLESTEROL BIOSYNTHESIS	24	2.20e-02	2.70e-01	9.61e-02
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	54	5.98e-04	-2.70e-01	7.26e-03
GAP JUNCTION DEGRADATION	11	1.21e-01	2.70e-01	3.12e-01
COPII MEDIATED VESICLE TRANSPORT	66	1.70e-04	2.68e-01	2.93e-03
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	66	1.73e-04	2.67e-01	2.93e-03
SIGNAL AMPLIFICATION	31	1.00e-02	2.67e-01	5.58e-02
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	6.42e-02	2.67e-01	2.02e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	9.58e-02	2.67e-01	2.70e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	9.61e-02	2.67e-01	2.70e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	4.87e-10	2.65e-01	4.78e-08
BUDDING AND MATURATION OF HIV VIRION	27	1.71e-02	2.65e-01	8.01e-02
SIGNALING BY HEDGEHOG	141	5.58e-08	2.65e-01	3.48e-06
DEPOLYMERISATION OF THE NUCLEAR LAMINA	13	9.80e-02	2.65e-01	2.72e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	28	1.53e-02	2.65e-01	7.60e-02
G ALPHA Z SIGNALLING EVENTS	45	2.20e-03	2.64e-01	1.98e-02
G1 S SPECIFIC TRANSCRIPTION	26	2.08e-02	2.62e-01	9.25e-02
NUCLEOTIDE SALVAGE	21	3.78e-02	2.62e-01	1.40e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	7.92e-02	2.62e-01	2.34e-01
FORMATION OF APOPTOSOME	10	1.52e-01	2.62e-01	3.69e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	3.32e-04	2.61e-01	4.77e-03
PENTOSE PHOSPHATE PATHWAY	13	1.03e-01	2.61e-01	2.84e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	1.53e-01	2.61e-01	3.70e-01
SEROTONIN RECEPTORS	10	1.55e-01	2.60e-01	3.71e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	7.18e-02	2.60e-01	2.19e-01
LAMININ INTERACTIONS	29	1.56e-02	-2.59e-01	7.69e-02
HEDGEHOG OFF STATE	106	3.98e-06	2.59e-01	1.42e-04
ERKS ARE INACTIVATED	13	1.06e-01	2.59e-01	2.86e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	1.81e-02	2.58e-01	8.35e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	4.62e-02	2.57e-01	1.63e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	5.97e-02	2.56e-01	1.93e-01
ACTIVATION OF RAC1	13	1.10e-01	2.56e-01	2.93e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	2.39e-02	2.56e-01	1.01e-01
FGFR2 LIGAND BINDING AND ACTIVATION	12	1.25e-01	-2.56e-01	3.20e-01
GLYCOSAMINOGLYCAN METABOLISM	113	2.78e-06	2.55e-01	1.13e-04
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	1.45e-01	2.54e-01	3.59e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	30	1.64e-02	2.53e-01	7.89e-02
PROCESSING AND ACTIVATION OF SUMO	10	1.66e-01	2.53e-01	3.88e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	8.71e-03	2.53e-01	5.11e-02
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	1.15e-01	-2.53e-01	3.01e-01
CHONDROITIN SULFATE BIOSYNTHESIS	18	6.42e-02	2.52e-01	2.02e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	9.13e-02	2.52e-01	2.60e-01
MITOPHAGY	29	1.94e-02	2.51e-01	8.74e-02
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	1.70e-01	-2.51e-01	3.93e-01
PROTEIN FOLDING	90	4.10e-05	2.50e-01	9.11e-04
O LINKED GLYCOSYLATION OF MUCINS	40	6.63e-03	2.48e-01	4.30e-02
TELOMERE C STRAND SYNTHESIS INITIATION	13	1.24e-01	2.46e-01	3.18e-01
METABOLISM OF POLYAMINES	57	1.34e-03	2.46e-01	1.39e-02
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	2.51e-02	2.45e-01	1.05e-01
RHOBTB2 GTPASE CYCLE	23	4.24e-02	2.45e-01	1.53e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	92	5.23e-05	2.44e-01	1.08e-03
INTERACTION BETWEEN L1 AND ANKYRINS	27	2.84e-02	-2.44e-01	1.14e-01
HEDGEHOG LIGAND BIOGENESIS	61	1.02e-03	2.43e-01	1.12e-02
PROLACTIN RECEPTOR SIGNALING	11	1.63e-01	2.43e-01	3.83e-01
ATTENUATION PHASE	23	4.41e-02	2.43e-01	1.58e-01
PROTEIN LOCALIZATION	158	1.54e-07	2.42e-01	8.66e-06
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	1.87e-01	2.41e-01	4.19e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	1.50e-01	2.40e-01	3.67e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	1.51e-01	2.40e-01	3.69e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	1.69e-01	-2.39e-01	3.93e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	5.79e-02	2.39e-01	1.90e-01
METABOLISM OF CARBOHYDRATES	260	3.79e-11	2.38e-01	7.43e-09
GABA RECEPTOR ACTIVATION	55	2.25e-03	2.38e-01	1.99e-02
PLATELET ADHESION TO EXPOSED COLLAGEN	13	1.37e-01	-2.38e-01	3.43e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.57e-02	2.38e-01	1.34e-01
SIGNALING BY NODAL	15	1.11e-01	-2.38e-01	2.93e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	35	1.54e-02	-2.37e-01	7.60e-02
G0 AND EARLY G1	25	4.06e-02	2.37e-01	1.48e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	6.88e-02	2.35e-01	2.13e-01
TRIGLYCERIDE CATABOLISM	14	1.29e-01	2.34e-01	3.28e-01
REGULATION OF IFNG SIGNALING	13	1.44e-01	2.34e-01	3.58e-01
ABC TRANSPORTER DISORDERS	70	7.36e-04	2.33e-01	8.76e-03
CHEMOKINE RECEPTORS BIND CHEMOKINES	17	9.62e-02	-2.33e-01	2.70e-01
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS	11	1.81e-01	-2.33e-01	4.09e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	1.43e-03	2.32e-01	1.44e-02
UNFOLDED PROTEIN RESPONSE UPR	85	2.14e-04	2.32e-01	3.46e-03
PLASMA LIPOPROTEIN CLEARANCE	28	3.40e-02	2.32e-01	1.31e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	1.11e-01	-2.30e-01	2.93e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	28	3.56e-02	2.29e-01	1.34e-01
GLUTATHIONE SYNTHESIS AND RECYCLING	11	1.88e-01	2.29e-01	4.19e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	12	1.70e-01	2.29e-01	3.93e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	3.04e-04	2.28e-01	4.54e-03
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	6.48e-03	2.27e-01	4.24e-02
EXTRA NUCLEAR ESTROGEN SIGNALING	68	1.20e-03	2.27e-01	1.28e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.73e-01	2.27e-01	3.97e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	73	8.08e-04	2.27e-01	9.16e-03
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	3.22e-02	2.26e-01	1.27e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	34	2.27e-02	2.26e-01	9.78e-02
INTEGRATION OF ENERGY METABOLISM	100	9.94e-05	2.25e-01	1.89e-03
METABOLISM OF NUCLEOTIDES	92	1.97e-04	2.25e-01	3.23e-03
PLATELET SENSITIZATION BY LDL	15	1.34e-01	2.23e-01	3.37e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	5.84e-02	2.23e-01	1.90e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	4.94e-02	2.23e-01	1.70e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	1.13e-01	-2.22e-01	2.97e-01
SYNTHESIS OF PA	29	3.93e-02	2.21e-01	1.44e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	9.64e-03	2.21e-01	5.44e-02
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	1.05e-01	2.20e-01	2.85e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	18	1.07e-01	2.20e-01	2.87e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	6.27e-03	2.19e-01	4.18e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	1.72e-01	-2.19e-01	3.96e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	2.33e-02	2.18e-01	1.00e-01
SCAVENGING OF HEME FROM PLASMA	12	1.91e-01	-2.18e-01	4.24e-01
SIGNAL TRANSDUCTION BY L1	21	8.47e-02	2.17e-01	2.46e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	41	1.61e-02	-2.17e-01	7.85e-02
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	1.45e-01	-2.17e-01	3.59e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	15	1.48e-01	2.16e-01	3.64e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	1.23e-01	2.16e-01	3.17e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	1.04e-01	2.15e-01	2.85e-01
PYRUVATE METABOLISM	27	5.33e-02	2.15e-01	1.78e-01
INTERLEUKIN 10 SIGNALING	19	1.05e-01	-2.15e-01	2.85e-01
SARS COV 2 INFECTION	65	2.78e-03	2.15e-01	2.29e-02
PROTEIN UBIQUITINATION	70	1.93e-03	2.14e-01	1.78e-02
MITOCHONDRIAL TRNA AMINOACYLATION	21	8.95e-02	2.14e-01	2.57e-01
SIALIC ACID METABOLISM	32	3.64e-02	2.14e-01	1.36e-01
PI 3K CASCADE FGFR2	17	1.27e-01	-2.14e-01	3.24e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	2.43e-01	-2.13e-01	4.84e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	24	7.15e-02	2.13e-01	2.19e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	66	2.88e-03	2.12e-01	2.36e-02
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	26	6.20e-02	2.11e-01	1.98e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	39	2.26e-02	2.11e-01	9.78e-02
HS GAG BIOSYNTHESIS	30	4.57e-02	2.11e-01	1.62e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	64	3.75e-03	-2.10e-01	2.82e-02
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	1.60e-01	2.09e-01	3.79e-01
MTORC1 MEDIATED SIGNALLING	24	7.66e-02	2.09e-01	2.30e-01
HDACS DEACETYLATE HISTONES	50	1.09e-02	-2.08e-01	6.03e-02
CGMP EFFECTS	15	1.65e-01	-2.07e-01	3.85e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	1.61e-03	2.07e-01	1.57e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	1.66e-01	-2.07e-01	3.88e-01
ACYL CHAIN REMODELLING OF PG	10	2.59e-01	2.06e-01	5.02e-01
FERTILIZATION	13	1.98e-01	-2.06e-01	4.32e-01
INTEGRIN CELL SURFACE INTERACTIONS	75	2.02e-03	-2.06e-01	1.85e-02
G BETA GAMMA SIGNALLING THROUGH CDC42	19	1.20e-01	2.06e-01	3.10e-01
FCERI MEDIATED NF KB ACTIVATION	76	1.90e-03	2.06e-01	1.77e-02
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	1.67e-01	2.06e-01	3.90e-01
INTRA GOLGI TRAFFIC	43	1.96e-02	2.06e-01	8.81e-02
TRANS GOLGI NETWORK VESICLE BUDDING	70	2.94e-03	2.06e-01	2.39e-02
PROCESSING OF SMDT1	16	1.55e-01	2.06e-01	3.71e-01
BETA CATENIN PHOSPHORYLATION CASCADE	16	1.55e-01	2.05e-01	3.71e-01
SYNTHESIS OF PC	26	7.09e-02	2.05e-01	2.19e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	109	2.30e-04	2.04e-01	3.66e-03
AMINE LIGAND BINDING RECEPTORS	29	5.70e-02	2.04e-01	1.88e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	42	2.24e-02	2.04e-01	9.75e-02
GABA B RECEPTOR ACTIVATION	40	2.62e-02	2.03e-01	1.07e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	4.69e-02	-2.03e-01	1.64e-01
REGULATION OF INSULIN SECRETION	72	2.98e-03	2.02e-01	2.41e-02
MTOR SIGNALLING	40	2.69e-02	2.02e-01	1.09e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	37	3.35e-02	2.02e-01	1.30e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	1.63e-01	-2.01e-01	3.83e-01
LATE ENDOSOMAL MICROAUTOPHAGY	32	4.89e-02	2.01e-01	1.69e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	1.61e-02	2.01e-01	7.85e-02
KINESINS	47	1.77e-02	2.00e-01	8.20e-02
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	84	1.55e-03	2.00e-01	1.53e-02
PROLONGED ERK ACTIVATION EVENTS	13	2.13e-01	1.99e-01	4.51e-01
NCAM1 INTERACTIONS	42	2.55e-02	-1.99e-01	1.06e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	1.44e-01	1.99e-01	3.58e-01
ERYTHROPOIETIN ACTIVATES RAS	13	2.14e-01	1.99e-01	4.51e-01
MEMBRANE TRAFFICKING	582	2.93e-16	1.99e-01	1.15e-13
PEPTIDE HORMONE METABOLISM	60	7.82e-03	1.99e-01	4.81e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	14	1.98e-01	1.99e-01	4.32e-01
CELLULAR RESPONSE TO HEAT STRESS	94	9.54e-04	1.97e-01	1.05e-02
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	51	1.51e-02	-1.97e-01	7.57e-02
ACTIVATION OF BH3 ONLY PROTEINS	30	6.25e-02	1.97e-01	1.99e-01
DEGRADATION OF GLI1 BY THE PROTEASOME	57	1.04e-02	1.96e-01	5.75e-02
HDR THROUGH SINGLE STRAND ANNEALING SSA	37	3.92e-02	-1.96e-01	1.44e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	23	1.04e-01	1.96e-01	2.85e-01
DISEASES OF DNA REPAIR	11	2.62e-01	1.95e-01	5.03e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	1.31e-02	1.95e-01	6.81e-02
REGULATION OF KIT SIGNALING	16	1.77e-01	1.95e-01	4.04e-01
CLATHRIN MEDIATED ENDOCYTOSIS	134	1.01e-04	1.95e-01	1.89e-03
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	1.32e-01	-1.94e-01	3.34e-01
STABILIZATION OF P53	54	1.36e-02	1.94e-01	6.93e-02
CA DEPENDENT EVENTS	36	4.38e-02	1.94e-01	1.57e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	1.33e-01	1.94e-01	3.35e-01
CD28 CO STIMULATION	31	6.21e-02	1.94e-01	1.98e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	182	6.78e-06	1.94e-01	2.22e-04
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	88	1.72e-03	1.93e-01	1.65e-02
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	7.71e-02	1.93e-01	2.30e-01
MITOTIC METAPHASE AND ANAPHASE	207	1.79e-06	1.93e-01	8.44e-05
FATTY ACID METABOLISM	146	6.12e-05	1.92e-01	1.21e-03
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	51	1.76e-02	-1.92e-01	8.20e-02
NEUTROPHIL DEGRANULATION	386	1.15e-10	1.91e-01	1.44e-08
REGULATION OF RAS BY GAPS	66	7.18e-03	1.91e-01	4.57e-02
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	75	4.23e-03	1.91e-01	3.08e-02
PINK1 PRKN MEDIATED MITOPHAGY	22	1.21e-01	1.91e-01	3.12e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	3.11e-03	1.90e-01	2.49e-02
E2F MEDIATED REGULATION OF DNA REPLICATION	19	1.52e-01	1.90e-01	3.69e-01
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	10	2.99e-01	-1.90e-01	5.46e-01
NEDDYLATION	219	1.33e-06	1.90e-01	6.54e-05
METHYLATION	11	2.77e-01	1.89e-01	5.19e-01
VXPX CARGO TARGETING TO CILIUM	19	1.53e-01	1.89e-01	3.70e-01
HEME SIGNALING	46	2.64e-02	-1.89e-01	1.07e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	3.03e-01	1.88e-01	5.50e-01
FC EPSILON RECEPTOR FCERI SIGNALING	123	3.19e-04	1.88e-01	4.65e-03
DSCAM INTERACTIONS	11	2.83e-01	-1.87e-01	5.24e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	8.12e-02	1.87e-01	2.39e-01
SYNTHESIS OF PE	13	2.44e-01	1.87e-01	4.84e-01
TBC RABGAPS	43	3.43e-02	1.87e-01	1.31e-01
AMINO ACIDS REGULATE MTORC1	51	2.15e-02	1.86e-01	9.47e-02
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	1.32e-01	1.86e-01	3.32e-01
VESICLE MEDIATED TRANSPORT	615	4.82e-15	1.85e-01	1.42e-12
NUCLEOBASE CATABOLISM	31	7.40e-02	1.85e-01	2.23e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	1.39e-02	1.85e-01	7.05e-02
NEGATIVE REGULATION OF MET ACTIVITY	20	1.52e-01	1.85e-01	3.70e-01
RHOF GTPASE CYCLE	41	4.11e-02	1.84e-01	1.49e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	23	1.27e-01	1.84e-01	3.24e-01
RESOLUTION OF SISTER CHROMATID COHESION	102	1.37e-03	1.83e-01	1.40e-02
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	2.09e-02	1.83e-01	9.27e-02
FCGR3A MEDIATED IL10 SYNTHESIS	32	7.32e-02	1.83e-01	2.22e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	12	2.74e-01	-1.83e-01	5.15e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	70	8.32e-03	1.82e-01	4.98e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	18	1.81e-01	1.82e-01	4.09e-01
METAL ION SLC TRANSPORTERS	25	1.16e-01	1.82e-01	3.03e-01
INTERFERON SIGNALING	162	6.96e-05	-1.81e-01	1.34e-03
DEFECTS IN COBALAMIN B12 METABOLISM	13	2.59e-01	1.81e-01	5.02e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	14	2.42e-01	1.81e-01	4.82e-01
RORA ACTIVATES GENE EXPRESSION	18	1.85e-01	-1.81e-01	4.15e-01
HEDGEHOG ON STATE	82	4.83e-03	1.80e-01	3.40e-02
METABOLISM OF FAT SOLUBLE VITAMINS	32	7.81e-02	1.80e-01	2.32e-01
CRMPS IN SEMA3A SIGNALING	16	2.14e-01	-1.80e-01	4.51e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	17	2.00e-01	1.79e-01	4.36e-01
CILIUM ASSEMBLY	192	1.94e-05	1.79e-01	5.19e-04
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	3.04e-01	1.79e-01	5.50e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION	34	7.12e-02	1.79e-01	2.19e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	107	1.40e-03	1.79e-01	1.42e-02
REDUCTION OF CYTOSOLIC CA LEVELS	12	2.87e-01	-1.77e-01	5.28e-01
GPCR LIGAND BINDING	271	5.44e-07	1.77e-01	2.91e-05
ASSEMBLY OF THE HIV VIRION	16	2.21e-01	1.77e-01	4.57e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	1.72e-01	1.76e-01	3.96e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	1.21e-01	-1.76e-01	3.12e-01
EPHB MEDIATED FORWARD SIGNALING	42	4.93e-02	1.75e-01	1.70e-01
COMPLEX I BIOGENESIS	56	2.34e-02	-1.75e-01	1.00e-01
COLLAGEN CHAIN TRIMERIZATION	41	5.26e-02	-1.75e-01	1.77e-01
FCERI MEDIATED MAPK ACTIVATION	28	1.10e-01	1.74e-01	2.93e-01
G ALPHA Q SIGNALLING EVENTS	155	1.82e-04	1.74e-01	3.02e-03
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	1.77e-01	1.74e-01	4.04e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	94	3.56e-03	1.74e-01	2.73e-02
EGFR DOWNREGULATION	28	1.11e-01	1.74e-01	2.94e-01
PI 3K CASCADE FGFR1	16	2.29e-01	-1.74e-01	4.69e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	243	3.18e-06	1.74e-01	1.25e-04
STRIATED MUSCLE CONTRACTION	27	1.19e-01	-1.74e-01	3.08e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	95	3.56e-03	1.73e-01	2.73e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	1.84e-02	1.73e-01	8.41e-02
SARS COV 1 INFECTION	48	3.84e-02	1.73e-01	1.42e-01
PCP CE PATHWAY	89	4.99e-03	1.72e-01	3.46e-02
SIGNALING BY FGFR3	34	8.24e-02	1.72e-01	2.41e-01
ACYL CHAIN REMODELLING OF PC	17	2.21e-01	1.72e-01	4.57e-01
SEPARATION OF SISTER CHROMATIDS	166	1.41e-04	1.71e-01	2.56e-03
PHOSPHOLIPID METABOLISM	188	5.25e-05	1.71e-01	1.08e-03
MITOTIC G1 PHASE AND G1 S TRANSITION	142	4.36e-04	1.71e-01	5.91e-03
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	3.13e-02	1.71e-01	1.24e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	9.98e-03	1.71e-01	5.58e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	1.58e-01	-1.70e-01	3.75e-01
G1 S DNA DAMAGE CHECKPOINTS	65	1.78e-02	1.70e-01	8.21e-02
GLUCOSE METABOLISM	81	8.68e-03	1.69e-01	5.11e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	27	1.30e-01	1.68e-01	3.29e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	32	9.98e-02	-1.68e-01	2.77e-01
TRANSCRIPTIONAL REGULATION BY MECP2	59	2.63e-02	-1.67e-01	1.07e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	68	1.74e-02	1.67e-01	8.14e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	24	1.57e-01	1.67e-01	3.74e-01
ANCHORING FIBRIL FORMATION	14	2.81e-01	-1.67e-01	5.22e-01
TIGHT JUNCTION INTERACTIONS	16	2.51e-01	1.66e-01	4.94e-01
NEGATIVE REGULATION OF MAPK PATHWAY	42	6.36e-02	1.65e-01	2.01e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	15	2.68e-01	1.65e-01	5.08e-01
SIGNALING BY FLT3 FUSION PROTEINS	19	2.13e-01	-1.65e-01	4.51e-01
SIGNALING BY FGFR4	34	9.67e-02	1.65e-01	2.70e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	2.70e-01	1.65e-01	5.11e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1230	4.88e-22	1.65e-01	5.75e-19
PRC2 METHYLATES HISTONES AND DNA	33	1.02e-01	-1.65e-01	2.81e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	1.14e-01	1.64e-01	2.98e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	3.06e-01	-1.64e-01	5.51e-01
INTERLEUKIN 12 FAMILY SIGNALING	43	6.30e-02	1.64e-01	2.00e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	3.56e-02	1.64e-01	1.34e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	1.84e-01	1.64e-01	4.14e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	224	2.59e-05	1.63e-01	6.36e-04
INTERLEUKIN 12 SIGNALING	37	8.60e-02	1.63e-01	2.48e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	3.73e-01	1.63e-01	6.07e-01
OPIOID SIGNALLING	87	8.99e-03	1.62e-01	5.21e-02
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	25	1.61e-01	-1.62e-01	3.80e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	3.78e-01	1.61e-01	6.07e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	3.55e-01	1.61e-01	5.98e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	187	1.58e-04	1.60e-01	2.82e-03
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	1.23e-02	1.60e-01	6.52e-02
ORC1 REMOVAL FROM CHROMATIN	67	2.36e-02	1.60e-01	1.00e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	3.60e-01	1.60e-01	6.01e-01
PRE NOTCH PROCESSING IN GOLGI	18	2.42e-01	1.59e-01	4.82e-01
MET ACTIVATES RAP1 AND RAC1	10	3.83e-01	1.59e-01	6.09e-01
RHO GTPASES ACTIVATE FORMINS	119	2.72e-03	1.59e-01	2.27e-02
FRS MEDIATED FGFR3 SIGNALING	15	2.86e-01	1.59e-01	5.26e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS	19	2.30e-01	-1.59e-01	4.71e-01
MITOCHONDRIAL PROTEIN IMPORT	63	2.94e-02	1.59e-01	1.17e-01
MUCOPOLYSACCHARIDOSES	11	3.63e-01	1.58e-01	6.02e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	2.32e-01	1.58e-01	4.72e-01
HOST INTERACTIONS OF HIV FACTORS	125	2.25e-03	1.58e-01	1.99e-02
EPH EPHRIN SIGNALING	92	8.94e-03	1.58e-01	5.21e-02
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	3.08e-01	1.57e-01	5.52e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	51	5.21e-02	1.57e-01	1.76e-01
SIGNALING BY HIPPO	20	2.24e-01	1.57e-01	4.61e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	1.20e-02	1.57e-01	6.43e-02
ENOS ACTIVATION	11	3.68e-01	1.57e-01	6.06e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	7.25e-02	1.57e-01	2.21e-01
DNA METHYLATION	24	1.85e-01	-1.56e-01	4.15e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	39	9.16e-02	-1.56e-01	2.60e-01
PARASITE INFECTION	54	4.74e-02	1.56e-01	1.66e-01
SIGNALING BY THE B CELL RECEPTOR BCR	103	6.35e-03	1.56e-01	4.20e-02
CHAPERONE MEDIATED AUTOPHAGY	21	2.17e-01	1.56e-01	4.53e-01
DNA REPLICATION PRE INITIATION	80	1.67e-02	1.55e-01	7.91e-02
DEGRADATION OF AXIN	53	5.13e-02	1.55e-01	1.75e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	1.61e-02	1.55e-01	7.85e-02
SHC1 EVENTS IN EGFR SIGNALING	11	3.74e-01	1.55e-01	6.07e-01
DEGRADATION OF DVL	55	4.82e-02	1.54e-01	1.67e-01
PHASE 2 PLATEAU PHASE	10	3.99e-01	-1.54e-01	6.24e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	2.59e-01	1.54e-01	5.02e-01
TCR SIGNALING	101	7.61e-03	1.54e-01	4.78e-02
COHESIN LOADING ONTO CHROMATIN	10	4.00e-01	-1.54e-01	6.24e-01
INOSITOL PHOSPHATE METABOLISM	46	7.16e-02	1.54e-01	2.19e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	2.13e-01	1.54e-01	4.51e-01
VITAMIN B5 PANTOTHENATE METABOLISM	15	3.04e-01	1.53e-01	5.50e-01
EUKARYOTIC TRANSLATION ELONGATION	88	1.30e-02	-1.53e-01	6.80e-02
RAB REGULATION OF TRAFFICKING	119	3.91e-03	1.53e-01	2.92e-02
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	12	3.59e-01	-1.53e-01	6.01e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	2.37e-01	1.53e-01	4.78e-01
METABOLISM OF LIPIDS	619	1.05e-10	1.53e-01	1.44e-08
THE NLRP3 INFLAMMASOME	15	3.08e-01	-1.52e-01	5.52e-01
G ALPHA I SIGNALLING EVENTS	207	1.74e-04	1.52e-01	2.93e-03
G PROTEIN MEDIATED EVENTS	52	5.97e-02	1.51e-01	1.93e-01
C TYPE LECTIN RECEPTORS CLRS	112	5.80e-03	1.51e-01	3.90e-02
TRAF6 MEDIATED IRF7 ACTIVATION	15	3.14e-01	-1.50e-01	5.57e-01
SYNAPTIC ADHESION LIKE MOLECULES	21	2.33e-01	1.50e-01	4.73e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	2.84e-01	1.50e-01	5.25e-01
MET ACTIVATES PTK2 SIGNALING	29	1.62e-01	-1.50e-01	3.83e-01
GP1B IX V ACTIVATION SIGNALLING	11	3.90e-01	-1.50e-01	6.16e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	25	1.97e-01	1.49e-01	4.30e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	8.49e-02	1.48e-01	2.46e-01
HYALURONAN METABOLISM	15	3.20e-01	1.48e-01	5.64e-01
INTERLEUKIN 15 SIGNALING	12	3.74e-01	-1.48e-01	6.07e-01
CLEC7A DECTIN 1 SIGNALING	94	1.33e-02	1.48e-01	6.83e-02
DEADENYLATION OF MRNA	25	2.02e-01	1.48e-01	4.36e-01
L1CAM INTERACTIONS	108	8.17e-03	1.47e-01	4.92e-02
AQUAPORIN MEDIATED TRANSPORT	41	1.04e-01	1.47e-01	2.84e-01
CELLULAR RESPONSE TO HYPOXIA	72	3.17e-02	1.46e-01	1.25e-01
DAG AND IP3 SIGNALING	40	1.13e-01	1.45e-01	2.97e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	24	2.19e-01	1.45e-01	4.57e-01
FGFR1 LIGAND BINDING AND ACTIVATION	10	4.28e-01	-1.45e-01	6.46e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	3.87e-01	1.44e-01	6.13e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	4.32e-01	1.44e-01	6.49e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	4.32e-01	1.44e-01	6.49e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	20	2.67e-01	1.43e-01	5.08e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	7.42e-02	1.43e-01	2.23e-01
SIGNALLING TO ERKS	33	1.55e-01	1.43e-01	3.71e-01
TNF SIGNALING	43	1.05e-01	1.43e-01	2.85e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	66	4.47e-02	-1.43e-01	1.60e-01
INTERLEUKIN 6 SIGNALING	10	4.34e-01	1.43e-01	6.50e-01
METABOLISM OF STEROIDS	117	7.75e-03	1.43e-01	4.81e-02
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	3.74e-01	1.42e-01	6.07e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	2.38e-01	1.42e-01	4.78e-01
FRS MEDIATED FGFR4 SIGNALING	15	3.41e-01	1.42e-01	5.84e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	2.85e-01	1.42e-01	5.25e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	59	6.00e-02	1.42e-01	1.93e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	64	5.12e-02	1.41e-01	1.75e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	2.14e-01	1.41e-01	4.51e-01
POLO LIKE KINASE MEDIATED EVENTS	14	3.66e-01	1.40e-01	6.05e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	95	1.89e-02	1.39e-01	8.61e-02
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	3.20e-01	1.39e-01	5.64e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	3.36e-01	-1.39e-01	5.79e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	119	9.07e-03	1.39e-01	5.21e-02
GLUTATHIONE CONJUGATION	30	1.89e-01	1.39e-01	4.20e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	4.26e-01	-1.39e-01	6.46e-01
DISEASES OF GLYCOSYLATION	123	8.06e-03	1.38e-01	4.89e-02
EPIGENETIC REGULATION OF GENE EXPRESSION	107	1.35e-02	-1.38e-01	6.92e-02
PURINE CATABOLISM	16	3.39e-01	1.38e-01	5.84e-01
PHASE II CONJUGATION OF COMPOUNDS	64	5.64e-02	1.38e-01	1.87e-01
PEPTIDE LIGAND BINDING RECEPTORS	112	1.19e-02	1.38e-01	6.42e-02
UNWINDING OF DNA	12	4.09e-01	1.38e-01	6.28e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	69	4.85e-02	-1.37e-01	1.68e-01
SARS COV INFECTIONS	140	5.05e-03	1.37e-01	3.48e-02
SEMA3A PAK DEPENDENT AXON REPULSION	16	3.42e-01	1.37e-01	5.85e-01
NEURONAL SYSTEM	370	6.14e-06	1.37e-01	2.07e-04
INTERLEUKIN 20 FAMILY SIGNALING	14	3.76e-01	-1.37e-01	6.07e-01
SIGNALING BY NTRKS	129	7.43e-03	1.37e-01	4.71e-02
ZINC TRANSPORTERS	16	3.46e-01	1.36e-01	5.88e-01
RMTS METHYLATE HISTONE ARGININES	47	1.08e-01	-1.36e-01	2.88e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	146	4.69e-03	1.36e-01	3.37e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	3.63e-01	1.36e-01	6.02e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	1.01e-01	1.36e-01	2.78e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	96	2.22e-02	-1.35e-01	9.67e-02
INNATE IMMUNE SYSTEM	779	1.71e-10	1.35e-01	1.83e-08
SIGNALING BY RETINOIC ACID	33	1.80e-01	1.35e-01	4.09e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES	316	3.92e-05	1.35e-01	8.88e-04
BIOLOGICAL OXIDATIONS	126	9.06e-03	1.35e-01	5.21e-02
SHC MEDIATED CASCADE FGFR3	13	4.01e-01	1.35e-01	6.24e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	4.02e-01	1.34e-01	6.24e-01
NONSENSE MEDIATED DECAY NMD	110	1.52e-02	-1.34e-01	7.60e-02
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	3.70e-01	1.34e-01	6.07e-01
RAS PROCESSING	24	2.58e-01	1.33e-01	5.02e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	4.05e-01	1.33e-01	6.24e-01
DNA REPLICATION	122	1.10e-02	1.33e-01	6.05e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS	27	2.31e-01	1.33e-01	4.71e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	4.66e-01	1.33e-01	6.77e-01
INTERLEUKIN 1 SIGNALING	96	2.43e-02	1.33e-01	1.02e-01
ADAPTIVE IMMUNE SYSTEM	611	2.37e-08	1.33e-01	1.70e-06
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	3.17e-01	1.33e-01	5.62e-01
SIGNALING BY EGFR	47	1.16e-01	1.32e-01	3.03e-01
GPVI MEDIATED ACTIVATION CASCADE	31	2.02e-01	1.32e-01	4.36e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	7.34e-02	1.32e-01	2.22e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	8.88e-02	1.31e-01	2.55e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	59	8.08e-02	1.31e-01	2.39e-01
CD209 DC SIGN SIGNALING	18	3.35e-01	1.31e-01	5.78e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	4.14e-01	-1.31e-01	6.32e-01
OTHER SEMAPHORIN INTERACTIONS	19	3.26e-01	-1.30e-01	5.69e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	3.82e-01	1.30e-01	6.09e-01
HOMOLOGY DIRECTED REPAIR	111	1.93e-02	-1.29e-01	8.72e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	4.61e-01	1.28e-01	6.74e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	2.17e-01	1.28e-01	4.53e-01
ESTROGEN DEPENDENT GENE EXPRESSION	108	2.15e-02	-1.28e-01	9.47e-02
DAP12 INTERACTIONS	30	2.25e-01	-1.28e-01	4.63e-01
PI3K EVENTS IN ERBB2 SIGNALING	15	3.91e-01	-1.28e-01	6.16e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	1.72e-01	-1.28e-01	3.96e-01
HIV INFECTION	221	1.07e-03	1.28e-01	1.14e-02
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	4.44e-01	1.28e-01	6.57e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	28	2.45e-01	-1.27e-01	4.85e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	26	2.63e-01	1.27e-01	5.03e-01
SIGNALING BY VEGF	103	2.63e-02	1.27e-01	1.07e-01
S PHASE	154	6.68e-03	1.27e-01	4.30e-02
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	2.38e-01	1.27e-01	4.78e-01
NUCLEAR SIGNALING BY ERBB4	31	2.23e-01	1.27e-01	4.60e-01
PI METABOLISM	80	5.04e-02	1.27e-01	1.73e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	27	2.56e-01	1.26e-01	5.01e-01
REGULATION OF TNFR1 SIGNALING	34	2.03e-01	1.26e-01	4.36e-01
REGULATION OF BACH1 ACTIVITY	11	4.69e-01	1.26e-01	6.78e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	3.55e-01	1.26e-01	5.98e-01
PEXOPHAGY	11	4.71e-01	1.26e-01	6.79e-01
SIGNALING BY GPCR	487	2.25e-06	1.25e-01	1.02e-04
FORMATION OF INCISION COMPLEX IN GG NER	43	1.56e-01	1.25e-01	3.71e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	27	2.61e-01	-1.25e-01	5.02e-01
TIE2 SIGNALING	17	3.73e-01	1.25e-01	6.07e-01
FORMATION OF THE CORNIFIED ENVELOPE	32	2.23e-01	1.24e-01	4.60e-01
JOSEPHIN DOMAIN DUBS	11	4.75e-01	1.24e-01	6.80e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	3.24e-01	1.24e-01	5.69e-01
TRANSLESION SYNTHESIS BY POLK	17	3.75e-01	-1.24e-01	6.07e-01
SIGNALING BY ERBB4	57	1.05e-01	1.24e-01	2.85e-01
DISEASES OF IMMUNE SYSTEM	25	2.83e-01	-1.24e-01	5.25e-01
PROGRAMMED CELL DEATH	186	3.60e-03	1.24e-01	2.73e-02
RHOBTB GTPASE CYCLE	35	2.05e-01	1.24e-01	4.38e-01
RHOV GTPASE CYCLE	33	2.20e-01	1.24e-01	4.57e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	4.99e-01	1.23e-01	7.04e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	62	9.34e-02	1.23e-01	2.64e-01
GLYCOLYSIS	67	8.15e-02	1.23e-01	2.39e-01
REGULATION OF FZD BY UBIQUITINATION	19	3.55e-01	1.22e-01	5.98e-01
HS GAG DEGRADATION	20	3.43e-01	1.22e-01	5.86e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	24	3.00e-01	-1.22e-01	5.47e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	288	3.76e-04	1.22e-01	5.21e-03
RESPIRATORY ELECTRON TRANSPORT	102	3.36e-02	-1.22e-01	1.30e-01
CHROMATIN MODIFYING ENZYMES	223	1.77e-03	-1.22e-01	1.68e-02
REGULATION OF IFNA SIGNALING	12	4.67e-01	-1.21e-01	6.77e-01
MITOTIC SPINDLE CHECKPOINT	97	3.96e-02	1.21e-01	1.45e-01
APOPTOSIS	164	7.63e-03	1.21e-01	4.78e-02
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	68	8.58e-02	1.21e-01	2.48e-01
PYRIMIDINE SALVAGE	10	5.10e-01	1.20e-01	7.11e-01
CONDENSATION OF PROPHASE CHROMOSOMES	31	2.47e-01	-1.20e-01	4.88e-01
ACTIVATION OF SMO	16	4.05e-01	1.20e-01	6.24e-01
RHO GTPASE EFFECTORS	253	1.05e-03	1.20e-01	1.13e-02
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	3.20e-01	1.20e-01	5.64e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	4.62e-02	1.20e-01	1.63e-01
OTHER INTERLEUKIN SIGNALING	20	3.56e-01	1.19e-01	5.98e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	5.14e-01	1.19e-01	7.13e-01
DNA DAMAGE RECOGNITION IN GG NER	38	2.03e-01	1.19e-01	4.36e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	3.24e-01	-1.19e-01	5.69e-01
DISEASES OF METABOLISM	197	4.19e-03	1.18e-01	3.08e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	3.48e-01	1.18e-01	5.90e-01
SIGNALING BY WNT IN CANCER	31	2.55e-01	1.18e-01	4.99e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	3.49e-01	1.18e-01	5.90e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	2.35e-01	1.18e-01	4.75e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	4.99e-01	1.18e-01	7.04e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	14	4.46e-01	-1.18e-01	6.59e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	5.00e-01	1.17e-01	7.04e-01
TELOMERE EXTENSION BY TELOMERASE	22	3.46e-01	1.16e-01	5.88e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	2.80e-01	1.16e-01	5.22e-01
METABOLISM OF FOLATE AND PTERINES	15	4.37e-01	1.16e-01	6.54e-01
TRIGLYCERIDE METABOLISM	24	3.27e-01	1.16e-01	5.70e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	15	4.39e-01	-1.15e-01	6.55e-01
METABOLISM OF VITAMINS AND COFACTORS	152	1.43e-02	1.15e-01	7.22e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	2.59e-01	1.15e-01	5.02e-01
TNFR2 NON CANONICAL NF KB PATHWAY	79	7.77e-02	1.15e-01	2.31e-01
SHC MEDIATED CASCADE FGFR4	13	4.73e-01	1.15e-01	6.80e-01
M PHASE	344	2.63e-04	1.15e-01	4.00e-03
INFLUENZA INFECTION	146	1.70e-02	-1.15e-01	8.00e-02
DNA DOUBLE STRAND BREAK REPAIR	140	1.98e-02	-1.14e-01	8.85e-02
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	3.44e-01	1.14e-01	5.87e-01
MITOTIC G2 G2 M PHASES	184	7.80e-03	1.14e-01	4.81e-02
GENE SILENCING BY RNA	86	6.84e-02	-1.14e-01	2.13e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	3.47e-01	-1.13e-01	5.88e-01
MITOTIC TELOPHASE CYTOKINESIS	13	4.81e-01	-1.13e-01	6.84e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	3.82e-01	-1.13e-01	6.09e-01
MAPK6 MAPK4 SIGNALING	83	7.69e-02	1.12e-01	2.30e-01
SIGNALING BY SCF KIT	41	2.13e-01	1.12e-01	4.51e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	53	1.59e-01	1.12e-01	3.77e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	284	1.22e-03	1.12e-01	1.29e-02
CYCLIN D ASSOCIATED EVENTS IN G1	45	1.96e-01	1.11e-01	4.30e-01
COSTIMULATION BY THE CD28 FAMILY	51	1.71e-01	1.11e-01	3.94e-01
BILE ACID AND BILE SALT METABOLISM	26	3.28e-01	1.11e-01	5.72e-01
INWARDLY RECTIFYING K CHANNELS	32	2.78e-01	1.11e-01	5.21e-01
KERATINIZATION	33	2.72e-01	1.11e-01	5.13e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	5.07e-01	-1.11e-01	7.10e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	3.41e-01	1.10e-01	5.84e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	3.72e-01	-1.10e-01	6.07e-01
INTERLEUKIN 1 FAMILY SIGNALING	123	3.59e-02	1.10e-01	1.34e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	29	3.07e-01	-1.10e-01	5.52e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	3.25e-01	1.09e-01	5.69e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	4.50e-01	1.09e-01	6.62e-01
SIGNALING BY FGFR2 IN DISEASE	37	2.52e-01	-1.09e-01	4.94e-01
HEMOSTASIS	478	4.81e-05	1.09e-01	1.05e-03
TRANSPORT OF SMALL MOLECULES	584	7.99e-06	1.08e-01	2.48e-04
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	102	5.92e-02	1.08e-01	1.92e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	348	5.91e-04	1.07e-01	7.25e-03
CELL CYCLE MITOTIC	479	6.17e-05	1.07e-01	1.21e-03
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	4.08e-01	-1.07e-01	6.27e-01
PTEN REGULATION	133	3.35e-02	1.07e-01	1.30e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	52	1.85e-01	-1.06e-01	4.16e-01
RHOBTB1 GTPASE CYCLE	23	3.78e-01	1.06e-01	6.07e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	140	3.07e-02	1.06e-01	1.22e-01
SIGNALING BY WNT	274	2.66e-03	1.06e-01	2.24e-02
FLT3 SIGNALING IN DISEASE	28	3.35e-01	-1.05e-01	5.78e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	2.45e-01	1.05e-01	4.85e-01
BIOTIN TRANSPORT AND METABOLISM	11	5.47e-01	-1.05e-01	7.40e-01
SIGNALING BY PTK6	50	2.03e-01	1.04e-01	4.36e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	2.40e-01	-1.04e-01	4.80e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	3.19e-01	-1.03e-01	5.64e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	51	2.03e-01	1.03e-01	4.36e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	5.20e-01	-1.03e-01	7.17e-01
RUNX3 REGULATES NOTCH SIGNALING	13	5.21e-01	-1.03e-01	7.17e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	15	4.90e-01	1.03e-01	6.94e-01
INITIAL TRIGGERING OF COMPLEMENT	12	5.38e-01	1.03e-01	7.35e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	30	3.32e-01	1.02e-01	5.75e-01
SENSORY PERCEPTION	162	2.56e-02	-1.02e-01	1.06e-01
RHOH GTPASE CYCLE	37	2.86e-01	1.01e-01	5.26e-01
SIGNALING BY NOTCH4	83	1.11e-01	1.01e-01	2.93e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	2.63e-01	1.01e-01	5.03e-01
ECM PROTEOGLYCANS	68	1.51e-01	-1.01e-01	3.69e-01
PHASE 0 RAPID DEPOLARISATION	28	3.58e-01	-1.00e-01	6.00e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	46	2.39e-01	-1.00e-01	4.79e-01
INTERLEUKIN 7 SIGNALING	19	4.49e-01	-1.00e-01	6.62e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	119	5.91e-02	1.00e-01	1.92e-01
RAC2 GTPASE CYCLE	87	1.07e-01	1.00e-01	2.87e-01
MEIOTIC RECOMBINATION	42	2.64e-01	-9.97e-02	5.03e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	5.19e-01	-9.95e-02	7.17e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	21	4.30e-01	9.94e-02	6.49e-01
RHOG GTPASE CYCLE	74	1.40e-01	9.93e-02	3.49e-01
VIRAL MESSENGER RNA SYNTHESIS	42	2.67e-01	-9.91e-02	5.08e-01
FANCONI ANEMIA PATHWAY	36	3.06e-01	-9.86e-02	5.51e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	5.72e-01	9.84e-02	7.61e-01
REGULATION OF PTEN GENE TRANSCRIPTION	58	1.96e-01	9.83e-02	4.29e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	3.87e-01	9.80e-02	6.13e-01
SIGNALING BY CSF3 G CSF	29	3.62e-01	9.79e-02	6.02e-01
INFLAMMASOMES	19	4.63e-01	-9.74e-02	6.76e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	4.11e-01	9.69e-02	6.28e-01
METABOLISM OF STEROID HORMONES	22	4.32e-01	9.68e-02	6.49e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	4.03e-01	9.66e-02	6.24e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	14	5.33e-01	9.62e-02	7.31e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	3.12e-01	-9.61e-02	5.55e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	5.07e-01	9.58e-02	7.10e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	5.67e-01	9.55e-02	7.56e-01
UB SPECIFIC PROCESSING PROTEASES	169	3.34e-02	9.50e-02	1.30e-01
HEME BIOSYNTHESIS	13	5.55e-01	9.46e-02	7.49e-01
DNA DAMAGE BYPASS	47	2.63e-01	-9.44e-02	5.03e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	6.86e-02	-9.44e-02	2.13e-01
G PROTEIN BETA GAMMA SIGNALLING	31	3.64e-01	9.42e-02	6.02e-01
NGF STIMULATED TRANSCRIPTION	36	3.30e-01	9.39e-02	5.73e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	5.90e-01	-9.38e-02	7.77e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	5.16e-01	9.38e-02	7.14e-01
ONCOGENIC MAPK SIGNALING	77	1.55e-01	9.37e-02	3.71e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT	11	5.92e-01	-9.32e-02	7.78e-01
TRANSLATION	287	6.66e-03	9.32e-02	4.30e-02
REPRODUCTION	81	1.49e-01	-9.28e-02	3.66e-01
SCAVENGING BY CLASS A RECEPTORS	14	5.48e-01	9.27e-02	7.40e-01
CELL CELL JUNCTION ORGANIZATION	48	2.67e-01	9.27e-02	5.08e-01
REGULATED PROTEOLYSIS OF P75NTR	12	5.79e-01	9.26e-02	7.67e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	4.66e-01	9.19e-02	6.77e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	57	2.31e-01	-9.18e-02	4.71e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	4.66e-01	9.18e-02	6.77e-01
NOTCH HLH TRANSCRIPTION PATHWAY	28	4.01e-01	-9.18e-02	6.24e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	28	4.03e-01	9.14e-02	6.24e-01
SIGNALING BY INSULIN RECEPTOR	65	2.03e-01	9.13e-02	4.36e-01
INTERLEUKIN 17 SIGNALING	68	1.93e-01	9.12e-02	4.26e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	65	2.04e-01	-9.12e-02	4.37e-01
RNA POLYMERASE I PROMOTER ESCAPE	51	2.61e-01	-9.10e-02	5.02e-01
RHOJ GTPASE CYCLE	54	2.48e-01	9.10e-02	4.89e-01
HIV ELONGATION ARREST AND RECOVERY	32	3.73e-01	-9.09e-02	6.07e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	69	1.92e-01	-9.09e-02	4.24e-01
NICOTINAMIDE SALVAGING	14	5.58e-01	-9.05e-02	7.51e-01
SIGNALING BY NTRK2 TRKB	24	4.43e-01	9.04e-02	6.57e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	3.07e-01	9.01e-02	5.51e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	6.23e-01	8.99e-02	7.98e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	20	4.87e-01	8.98e-02	6.91e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	284	9.58e-03	8.95e-02	5.44e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	4.78e-01	8.95e-02	6.82e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	1.87e-01	-8.94e-02	4.18e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	77	1.75e-01	8.94e-02	4.01e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	2.32e-01	8.93e-02	4.72e-01
CELL CYCLE CHECKPOINTS	245	1.65e-02	8.90e-02	7.89e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT	192	3.42e-02	8.87e-02	1.31e-01
NEUROTRANSMITTER RELEASE CYCLE	48	2.89e-01	8.86e-02	5.29e-01
NEGATIVE REGULATION OF FLT3	14	5.66e-01	-8.85e-02	7.56e-01
SIGNALING BY FGFR1	44	3.10e-01	8.85e-02	5.53e-01
BASE EXCISION REPAIR AP SITE FORMATION	33	3.83e-01	-8.78e-02	6.09e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	4.48e-01	-8.76e-02	6.62e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	6.16e-01	8.74e-02	7.95e-01
MITOTIC PROPHASE	98	1.36e-01	8.73e-02	3.40e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	4.01e-01	-8.72e-02	6.24e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	181	4.33e-02	8.72e-02	1.56e-01
TRAFFICKING OF AMPA RECEPTORS	31	4.02e-01	8.70e-02	6.24e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	2.74e-01	8.69e-02	5.15e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	6.19e-01	-8.66e-02	7.96e-01
INTEGRIN SIGNALING	24	4.63e-01	8.65e-02	6.76e-01
RESOLUTION OF ABASIC SITES AP SITES	38	3.59e-01	-8.60e-02	6.01e-01
G PROTEIN ACTIVATION	23	4.76e-01	8.59e-02	6.80e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	4.01e-01	-8.58e-02	6.24e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	3.91e-01	8.51e-02	6.16e-01
MUSCLE CONTRACTION	161	6.33e-02	-8.49e-02	2.00e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	5.97e-01	-8.47e-02	7.82e-01
MITOTIC PROMETAPHASE	177	5.22e-02	8.47e-02	1.76e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	462	1.90e-03	8.45e-02	1.77e-02
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	12	6.14e-01	8.42e-02	7.95e-01
INTERLEUKIN 6 FAMILY SIGNALING	20	5.16e-01	8.39e-02	7.14e-01
PI 3K CASCADE FGFR4	13	6.01e-01	-8.37e-02	7.83e-01
ADHERENS JUNCTIONS INTERACTIONS	30	4.32e-01	8.29e-02	6.49e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	5.92e-01	8.26e-02	7.78e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	4.42e-01	8.26e-02	6.57e-01
SIGNALING BY INTERLEUKINS	349	8.51e-03	8.21e-02	5.06e-02
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	84	1.94e-01	8.21e-02	4.26e-01
RRNA PROCESSING IN THE MITOCHONDRION	10	6.53e-01	8.20e-02	8.18e-01
RA BIOSYNTHESIS PATHWAY	13	6.11e-01	-8.14e-02	7.94e-01
NEPHRIN FAMILY INTERACTIONS	23	5.00e-01	8.12e-02	7.04e-01
TOLL LIKE RECEPTOR CASCADES	138	1.02e-01	8.07e-02	2.81e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	5.43e-01	8.06e-02	7.37e-01
TRNA PROCESSING IN THE NUCLEUS	56	2.97e-01	8.06e-02	5.43e-01
HDR THROUGH MMEJ ALT NHEJ	10	6.59e-01	-8.05e-02	8.21e-01
CELL CYCLE	598	8.01e-04	8.05e-02	9.16e-03
HCMV INFECTION	107	1.52e-01	8.02e-02	3.69e-01
PLATELET CALCIUM HOMEOSTASIS	26	4.80e-01	-8.00e-02	6.84e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	4.57e-01	7.99e-02	6.70e-01
RHOD GTPASE CYCLE	51	3.24e-01	7.98e-02	5.69e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	5.08e-01	7.97e-02	7.10e-01
ENDOGENOUS STEROLS	20	5.37e-01	-7.97e-02	7.35e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	74	2.40e-01	-7.90e-02	4.80e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	5.14e-01	-7.87e-02	7.13e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	3.01e-01	7.85e-02	5.49e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	36	4.17e-01	-7.81e-02	6.35e-01
O LINKED GLYCOSYLATION	85	2.15e-01	7.79e-02	4.51e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	94	1.92e-01	7.79e-02	4.24e-01
MAP2K AND MAPK ACTIVATION	36	4.19e-01	7.78e-02	6.37e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	183	7.28e-02	-7.70e-02	2.21e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	14	6.18e-01	7.69e-02	7.96e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	6.32e-01	-7.66e-02	8.03e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	369	1.17e-02	7.66e-02	6.34e-02
METABOLISM OF COFACTORS	19	5.64e-01	7.65e-02	7.56e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	44	3.81e-01	7.64e-02	6.09e-01
IRS MEDIATED SIGNALLING	41	3.98e-01	-7.64e-02	6.24e-01
INFECTIOUS DISEASE	739	4.47e-04	7.62e-02	5.98e-03
MYOGENESIS	25	5.11e-01	-7.59e-02	7.11e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	5.48e-01	7.58e-02	7.40e-01
RAC3 GTPASE CYCLE	90	2.20e-01	7.49e-02	4.57e-01
IRAK4 DEFICIENCY TLR2 4	14	6.29e-01	-7.45e-02	8.02e-01
RND3 GTPASE CYCLE	38	4.27e-01	7.44e-02	6.46e-01
PRE NOTCH EXPRESSION AND PROCESSING	68	2.90e-01	-7.42e-02	5.32e-01
FOXO MEDIATED TRANSCRIPTION	57	3.34e-01	-7.41e-02	5.78e-01
RHO GTPASES ACTIVATE CIT	18	5.88e-01	-7.38e-02	7.76e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	43	4.04e-01	7.35e-02	6.24e-01
P38MAPK EVENTS	13	6.48e-01	7.31e-02	8.15e-01
G ALPHA S SIGNALLING EVENTS	108	1.90e-01	7.30e-02	4.22e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	15	6.27e-01	7.24e-02	8.01e-01
TRP CHANNELS	20	5.75e-01	-7.23e-02	7.64e-01
MICRORNA MIRNA BIOGENESIS	24	5.40e-01	-7.22e-02	7.36e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	4.50e-01	-7.17e-02	6.62e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	5.99e-01	-7.17e-02	7.82e-01
RHOU GTPASE CYCLE	34	4.72e-01	7.14e-02	6.79e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	35	4.66e-01	-7.12e-02	6.77e-01
DEUBIQUITINATION	243	5.68e-02	7.10e-02	1.87e-01
MEIOSIS	68	3.12e-01	-7.10e-02	5.55e-01
ONCOGENE INDUCED SENESCENCE	32	4.88e-01	7.09e-02	6.91e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	6.24e-01	-7.09e-02	7.98e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	2.60e-01	7.07e-02	5.02e-01
RNA POLYMERASE I TRANSCRIPTION	71	3.04e-01	-7.06e-02	5.50e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	630	2.58e-03	7.06e-02	2.19e-02
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	97	2.33e-01	7.01e-02	4.73e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	33	4.87e-01	7.00e-02	6.91e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	60	3.49e-01	-6.99e-02	5.90e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS	12	6.76e-01	6.98e-02	8.33e-01
HATS ACETYLATE HISTONES	97	2.36e-01	-6.97e-02	4.77e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	3.78e-01	-6.94e-02	6.07e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	6.78e-01	-6.92e-02	8.33e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	4.41e-01	-6.87e-02	6.57e-01
LEISHMANIA INFECTION	199	9.66e-02	6.84e-02	2.70e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	16	6.37e-01	6.82e-02	8.06e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	6.97e-01	6.79e-02	8.48e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	24	5.66e-01	-6.76e-02	7.56e-01
GAB1 SIGNALOSOME	14	6.61e-01	-6.76e-02	8.23e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	6.85e-01	6.76e-02	8.40e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	5.98e-01	6.65e-02	7.82e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	3.78e-01	6.63e-02	6.07e-01
SIGNALING BY NOTCH2	33	5.10e-01	6.62e-02	7.11e-01
MAPK FAMILY SIGNALING CASCADES	290	5.28e-02	6.62e-02	1.77e-01
POTASSIUM CHANNELS	90	2.79e-01	6.60e-02	5.22e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	6.93e-01	6.58e-02	8.45e-01
INTERLEUKIN 37 SIGNALING	18	6.30e-01	6.57e-02	8.02e-01
THE PHOTOTRANSDUCTION CASCADE	22	5.94e-01	-6.56e-02	7.79e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	33	5.15e-01	6.55e-02	7.14e-01
RNA POLYMERASE III TRANSCRIPTION	41	4.70e-01	-6.52e-02	6.79e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	6.33e-01	6.50e-02	8.03e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	6.66e-01	-6.45e-02	8.24e-01
RHOA GTPASE CYCLE	141	1.88e-01	6.42e-02	4.19e-01
PI 3K CASCADE FGFR3	13	6.89e-01	-6.40e-02	8.43e-01
PLATELET AGGREGATION PLUG FORMATION	32	5.33e-01	6.38e-02	7.31e-01
POTENTIAL THERAPEUTICS FOR SARS	77	3.34e-01	6.37e-02	5.78e-01
METABOLISM OF PORPHYRINS	19	6.31e-01	6.36e-02	8.02e-01
CRISTAE FORMATION	31	5.40e-01	6.36e-02	7.36e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	42	4.76e-01	-6.36e-02	6.80e-01
DUAL INCISION IN TC NER	65	3.76e-01	-6.35e-02	6.07e-01
SIGNALING BY BMP	25	5.84e-01	6.33e-02	7.73e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	23	5.99e-01	-6.33e-02	7.82e-01
MEIOTIC SYNAPSIS	44	4.68e-01	-6.33e-02	6.77e-01
LONG TERM POTENTIATION	23	6.00e-01	6.32e-02	7.82e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	607	8.06e-03	6.32e-02	4.89e-02
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	7.06e-01	6.29e-02	8.56e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	3.17e-01	6.28e-02	5.62e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	4.05e-01	-6.16e-02	6.24e-01
CARDIAC CONDUCTION	107	2.71e-01	-6.16e-02	5.13e-01
CELL JUNCTION ORGANIZATION	73	3.64e-01	6.15e-02	6.02e-01
HIV LIFE CYCLE	142	2.07e-01	6.15e-02	4.41e-01
G2 M CHECKPOINTS	136	2.16e-01	6.14e-02	4.53e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	4.88e-01	-6.12e-02	6.91e-01
BASE EXCISION REPAIR	61	4.09e-01	-6.11e-02	6.28e-01
SEMAPHORIN INTERACTIONS	64	3.99e-01	-6.10e-02	6.24e-01
SELENOAMINO ACID METABOLISM	109	2.74e-01	-6.07e-02	5.15e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	7.41e-01	6.03e-02	8.70e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING	10	7.42e-01	-6.01e-02	8.70e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	108	2.81e-01	6.01e-02	5.22e-01
SIGNALING BY FGFR	74	3.74e-01	5.98e-02	6.07e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	7.22e-01	-5.93e-02	8.67e-01
DNA REPAIR	296	8.12e-02	-5.90e-02	2.39e-01
PLASMA LIPOPROTEIN ASSEMBLY	12	7.24e-01	5.88e-02	8.67e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	6.49e-01	5.88e-02	8.15e-01
SODIUM CALCIUM EXCHANGERS	10	7.48e-01	-5.87e-02	8.72e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	7.37e-01	5.85e-02	8.68e-01
PHOSPHORYLATION OF THE APC C	17	6.79e-01	5.81e-02	8.33e-01
REGULATION OF SIGNALING BY CBL	22	6.38e-01	5.80e-02	8.06e-01
DISEASES OF MITOTIC CELL CYCLE	37	5.43e-01	5.78e-02	7.37e-01
ANTIGEN PROCESSING CROSS PRESENTATION	96	3.29e-01	5.77e-02	5.72e-01
COLLAGEN DEGRADATION	52	4.74e-01	-5.74e-02	6.80e-01
CELL CELL COMMUNICATION	106	3.09e-01	5.72e-02	5.53e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE	39	5.37e-01	-5.71e-02	7.35e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	5.56e-01	5.68e-02	7.49e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	7.37e-01	-5.61e-02	8.68e-01
RHO GTPASES ACTIVATE KTN1	11	7.48e-01	5.60e-02	8.72e-01
RRNA PROCESSING	195	1.79e-01	-5.58e-02	4.08e-01
SUMOYLATION	168	2.13e-01	-5.57e-02	4.51e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	6.15e-01	-5.50e-02	7.95e-01
DUAL INCISION IN GG NER	41	5.43e-01	-5.49e-02	7.37e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	6.17e-01	5.47e-02	7.96e-01
COLLAGEN FORMATION	79	4.02e-01	-5.45e-02	6.24e-01
DEATH RECEPTOR SIGNALLING	132	2.82e-01	5.43e-02	5.24e-01
SIGNALING BY TGFB FAMILY MEMBERS	96	3.63e-01	5.37e-02	6.02e-01
RET SIGNALING	38	5.69e-01	5.34e-02	7.58e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	63	4.64e-01	-5.34e-02	6.76e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	94	3.73e-01	5.32e-02	6.07e-01
APOPTOTIC EXECUTION PHASE	45	5.37e-01	5.31e-02	7.35e-01
MITOCHONDRIAL TRANSLATION	93	3.77e-01	5.31e-02	6.07e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	7.23e-01	5.29e-02	8.67e-01
UCH PROTEINASES	90	3.87e-01	5.28e-02	6.13e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	6.76e-01	-5.28e-02	8.33e-01
SIGNALING BY FGFR2	63	4.73e-01	5.23e-02	6.80e-01
NUCLEAR ENVELOPE BREAKDOWN	49	5.28e-01	5.21e-02	7.26e-01
G2 M DNA DAMAGE CHECKPOINT	69	4.56e-01	-5.19e-02	6.70e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	7.77e-01	5.18e-02	8.94e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	7.39e-01	5.13e-02	8.68e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	6.65e-01	5.11e-02	8.24e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	11	7.70e-01	5.10e-02	8.89e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	92	3.98e-01	5.10e-02	6.24e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	7.09e-01	-5.09e-02	8.58e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	4.11e-01	-5.07e-02	6.28e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	6.09e-01	5.07e-02	7.92e-01
TRIGLYCERIDE BIOSYNTHESIS	10	7.82e-01	-5.05e-02	8.98e-01
MET PROMOTES CELL MOTILITY	39	5.87e-01	-5.03e-02	7.75e-01
COMPLEMENT CASCADE	26	6.62e-01	4.95e-02	8.23e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	4.17e-01	4.93e-02	6.35e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	5.86e-01	4.92e-02	7.75e-01
EFFECTS OF PIP2 HYDROLYSIS	27	6.59e-01	-4.91e-02	8.21e-01
MRNA SPLICING	188	2.49e-01	4.88e-02	4.90e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	83	4.42e-01	4.88e-02	6.57e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	62	5.08e-01	-4.87e-02	7.10e-01
PI3K AKT SIGNALING IN CANCER	91	4.23e-01	4.87e-02	6.42e-01
EUKARYOTIC TRANSLATION INITIATION	115	3.68e-01	-4.86e-02	6.06e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	7.82e-01	4.82e-02	8.98e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	14	7.56e-01	4.80e-02	8.77e-01
RHOC GTPASE CYCLE	73	4.80e-01	4.78e-02	6.84e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	6.58e-01	-4.75e-02	8.21e-01
CYTOPROTECTION BY HMOX1	119	3.72e-01	4.74e-02	6.07e-01
SURFACTANT METABOLISM	16	7.43e-01	4.74e-02	8.70e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	83	4.59e-01	4.70e-02	6.73e-01
VISUAL PHOTOTRANSDUCTION	62	5.23e-01	4.69e-02	7.20e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	50	5.74e-01	-4.60e-02	7.63e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	20	7.22e-01	4.60e-02	8.67e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	108	4.11e-01	-4.58e-02	6.28e-01
BASIGIN INTERACTIONS	22	7.12e-01	4.55e-02	8.61e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	4.43e-01	4.53e-02	6.57e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	6.34e-01	-4.52e-02	8.03e-01
RHO GTPASES ACTIVATE ROCKS	19	7.33e-01	-4.52e-02	8.68e-01
ERBB2 REGULATES CELL MOTILITY	14	7.71e-01	4.49e-02	8.90e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	107	4.23e-01	-4.48e-02	6.42e-01
REGULATION OF TP53 ACTIVITY	152	3.41e-01	4.48e-02	5.84e-01
SLC TRANSPORTER DISORDERS	76	5.02e-01	4.45e-02	7.06e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	6.68e-01	-4.45e-02	8.27e-01
NICOTINATE METABOLISM	23	7.13e-01	4.44e-02	8.61e-01
STIMULI SENSING CHANNELS	76	5.10e-01	-4.38e-02	7.11e-01
RND1 GTPASE CYCLE	38	6.42e-01	4.35e-02	8.09e-01
ERK MAPK TARGETS	22	7.26e-01	4.31e-02	8.67e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	12	7.96e-01	4.30e-02	9.06e-01
RHO GTPASES ACTIVATE PAKS	21	7.34e-01	4.29e-02	8.68e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	7.53e-01	-4.29e-02	8.76e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	7.82e-01	4.27e-02	8.98e-01
SIGNALING BY ACTIVIN	11	8.10e-01	4.19e-02	9.13e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	150	3.77e-01	4.19e-02	6.07e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	7.94e-01	-4.17e-02	9.06e-01
EARLY PHASE OF HIV LIFE CYCLE	13	7.95e-01	4.16e-02	9.06e-01
SIGNALING BY ERBB2	48	6.19e-01	4.16e-02	7.96e-01
RHO GTPASE CYCLE	423	1.44e-01	4.15e-02	3.58e-01
EXTRACELLULAR MATRIX ORGANIZATION	250	2.60e-01	-4.14e-02	5.02e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	7.34e-01	-4.09e-02	8.68e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	11	8.15e-01	-4.08e-02	9.16e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	7.00e-01	4.06e-02	8.50e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	7.25e-01	-4.06e-02	8.67e-01
SIGNALING BY NOTCH1	75	5.47e-01	4.02e-02	7.40e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	33	6.91e-01	-4.00e-02	8.44e-01
ELASTIC FIBRE FORMATION	38	6.72e-01	-3.96e-02	8.31e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	5.61e-01	3.91e-02	7.55e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	7.32e-01	3.89e-02	8.68e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	33	6.99e-01	3.89e-02	8.50e-01
REGULATION OF BETA CELL DEVELOPMENT	30	7.14e-01	-3.87e-02	8.62e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	74	5.66e-01	-3.86e-02	7.56e-01
LGI ADAM INTERACTIONS	14	8.04e-01	3.84e-02	9.11e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	50	6.40e-01	-3.82e-02	8.07e-01
GLUCAGON TYPE LIGAND RECEPTORS	26	7.39e-01	3.77e-02	8.68e-01
SMOOTH MUSCLE CONTRACTION	33	7.08e-01	-3.77e-02	8.58e-01
VOLTAGE GATED POTASSIUM CHANNELS	38	6.88e-01	3.77e-02	8.42e-01
CHROMOSOME MAINTENANCE	106	5.04e-01	-3.75e-02	7.08e-01
MRNA CAPPING	29	7.27e-01	3.74e-02	8.67e-01
SIGNALING BY ERYTHROPOIETIN	24	7.54e-01	-3.70e-02	8.76e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	7.49e-01	3.70e-02	8.72e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	6.26e-01	3.67e-02	8.00e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	6.40e-01	-3.65e-02	8.07e-01
ERBB2 ACTIVATES PTK6 SIGNALING	11	8.34e-01	-3.64e-02	9.22e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	8.20e-01	-3.64e-02	9.17e-01
SIGNALING BY MET	74	5.90e-01	3.63e-02	7.77e-01
POLYMERASE SWITCHING	14	8.15e-01	-3.62e-02	9.16e-01
CROSSLINKING OF COLLAGEN FIBRILS	15	8.09e-01	-3.61e-02	9.13e-01
NRAGE SIGNALS DEATH THROUGH JNK	54	6.48e-01	-3.60e-02	8.15e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	8.45e-01	-3.57e-02	9.24e-01
SIGNALING BY LEPTIN	10	8.45e-01	-3.57e-02	9.24e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	13	8.24e-01	3.56e-02	9.20e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	26	7.55e-01	-3.54e-02	8.77e-01
AMYLOID FIBER FORMATION	62	6.31e-01	-3.52e-02	8.02e-01
GENERATION OF SECOND MESSENGER MOLECULES	19	7.91e-01	-3.51e-02	9.04e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	8.41e-01	3.49e-02	9.24e-01
DNA STRAND ELONGATION	32	7.34e-01	3.47e-02	8.68e-01
SIGNALING BY PDGF	56	6.54e-01	-3.47e-02	8.18e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	8.11e-01	-3.46e-02	9.13e-01
FLT3 SIGNALING	36	7.20e-01	-3.46e-02	8.67e-01
CELLULAR HEXOSE TRANSPORT	12	8.36e-01	3.45e-02	9.22e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	3.63e-01	3.44e-02	6.02e-01
SIGNALING BY FGFR2 IIIA TM	19	7.95e-01	-3.44e-02	9.06e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	7.29e-01	3.39e-02	8.67e-01
METABOLISM OF AMINE DERIVED HORMONES	10	8.53e-01	3.39e-02	9.29e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	87	5.85e-01	3.39e-02	7.75e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	6.90e-01	-3.36e-02	8.43e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	73	6.20e-01	-3.36e-02	7.97e-01
MRNA SPLICING MINOR PATHWAY	52	6.78e-01	3.33e-02	8.33e-01
HCMV EARLY EVENTS	84	6.01e-01	3.30e-02	7.83e-01
SIGNALING BY NOTCH	193	4.37e-01	3.25e-02	6.54e-01
TELOMERE MAINTENANCE	82	6.14e-01	-3.22e-02	7.95e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	7.61e-01	3.21e-02	8.81e-01
NUCLEOTIDE EXCISION REPAIR	110	5.63e-01	3.19e-02	7.56e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	110	5.64e-01	-3.18e-02	7.56e-01
HCMV LATE EVENTS	69	6.50e-01	-3.16e-02	8.15e-01
RND2 GTPASE CYCLE	39	7.39e-01	3.09e-02	8.68e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	6.84e-01	-3.06e-02	8.40e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	7.48e-01	-3.05e-02	8.72e-01
HIV TRANSCRIPTION INITIATION	45	7.25e-01	-3.04e-02	8.67e-01
MITOCHONDRIAL BIOGENESIS	92	6.15e-01	-3.03e-02	7.95e-01
FCERI MEDIATED CA 2 MOBILIZATION	26	7.91e-01	3.00e-02	9.04e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	8.18e-01	2.98e-02	9.16e-01
CA2 PATHWAY	59	6.93e-01	2.97e-02	8.45e-01
INSULIN RECEPTOR SIGNALLING CASCADE	46	7.28e-01	-2.97e-02	8.67e-01
SIGNALING BY NUCLEAR RECEPTORS	229	4.44e-01	2.94e-02	6.57e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	23	8.07e-01	-2.94e-02	9.13e-01
EXTENSION OF TELOMERES	49	7.22e-01	2.94e-02	8.67e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	48	7.26e-01	-2.93e-02	8.67e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	8.30e-01	2.92e-02	9.21e-01
NONHOMOLOGOUS END JOINING NHEJ	46	7.32e-01	-2.92e-02	8.68e-01
REGULATED NECROSIS	46	7.35e-01	2.88e-02	8.68e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	24	8.08e-01	2.87e-02	9.13e-01
OXIDATIVE STRESS INDUCED SENESCENCE	82	6.57e-01	-2.84e-02	8.20e-01
SIGNALING BY KIT IN DISEASE	20	8.27e-01	2.82e-02	9.21e-01
G ALPHA 12 13 SIGNALLING EVENTS	75	6.77e-01	2.79e-02	8.33e-01
PREGNENOLONE BIOSYNTHESIS	12	8.69e-01	-2.75e-02	9.38e-01
LAGGING STRAND SYNTHESIS	20	8.34e-01	-2.70e-02	9.22e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	18	8.45e-01	2.66e-02	9.24e-01
TRANSLESION SYNTHESIS BY POLH	19	8.43e-01	-2.63e-02	9.24e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	8.60e-01	2.62e-02	9.34e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	7.76e-01	2.57e-02	8.94e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	8.46e-01	2.57e-02	9.25e-01
NEUREXINS AND NEUROLIGINS	54	7.44e-01	2.57e-02	8.71e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	8.17e-01	-2.53e-02	9.16e-01
RNA POLYMERASE III CHAIN ELONGATION	18	8.53e-01	-2.52e-02	9.29e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	32	8.09e-01	2.47e-02	9.13e-01
CIRCADIAN CLOCK	68	7.28e-01	-2.44e-02	8.67e-01
FRS MEDIATED FGFR1 SIGNALING	18	8.58e-01	2.43e-02	9.33e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	10	8.95e-01	-2.41e-02	9.46e-01
SIGNALING BY FGFR1 IN DISEASE	33	8.11e-01	2.41e-02	9.13e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	8.42e-01	2.41e-02	9.24e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	26	8.32e-01	-2.41e-02	9.22e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	8.95e-01	2.40e-02	9.46e-01
METABOLISM OF RNA	645	3.02e-01	2.39e-02	5.49e-01
ION CHANNEL TRANSPORT	143	6.23e-01	2.38e-02	7.98e-01
CELLULAR RESPONSE TO STARVATION	147	6.22e-01	-2.36e-02	7.98e-01
SIGNALING BY FGFR4 IN DISEASE	11	8.94e-01	2.32e-02	9.46e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	12	8.92e-01	2.26e-02	9.46e-01
ACYL CHAIN REMODELLING OF PS	14	8.84e-01	2.26e-02	9.45e-01
ANTIMICROBIAL PEPTIDES	15	8.82e-01	2.22e-02	9.45e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	8.21e-01	-2.21e-02	9.17e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	63	7.62e-01	-2.21e-02	8.81e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	8.27e-01	2.20e-02	9.21e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	8.65e-01	2.19e-02	9.38e-01
NERVOUS SYSTEM DEVELOPMENT	554	3.80e-01	2.19e-02	6.08e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	8.88e-01	2.18e-02	9.46e-01
FRS MEDIATED FGFR2 SIGNALING	19	8.70e-01	-2.16e-02	9.39e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	8.30e-01	-2.16e-02	9.21e-01
SIGNALING BY NTRK3 TRKC	17	8.78e-01	-2.16e-02	9.43e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	9.09e-01	-2.09e-02	9.52e-01
RHOQ GTPASE CYCLE	58	7.85e-01	2.07e-02	8.99e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	8.37e-01	2.07e-02	9.22e-01
RNA POLYMERASE II TRANSCRIPTION	1098	2.55e-01	-2.05e-02	4.99e-01
CDC42 GTPASE CYCLE	153	6.63e-01	-2.04e-02	8.23e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	93	7.36e-01	2.02e-02	8.68e-01
PLATELET HOMEOSTASIS	78	7.58e-01	2.02e-02	8.78e-01
IRAK1 RECRUITS IKK COMPLEX	14	8.97e-01	2.00e-02	9.47e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	8.81e-01	-1.98e-02	9.45e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	7.63e-01	1.98e-02	8.82e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	6.56e-01	1.97e-02	8.20e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	7.86e-01	-1.95e-02	9.00e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	8.48e-01	-1.93e-02	9.25e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	8.92e-01	1.91e-02	9.46e-01
PYROPTOSIS	21	8.80e-01	1.90e-02	9.45e-01
NETRIN 1 SIGNALING	50	8.16e-01	1.90e-02	9.16e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	48	8.28e-01	-1.81e-02	9.21e-01
SNRNP ASSEMBLY	51	8.25e-01	1.79e-02	9.20e-01
CARNITINE METABOLISM	14	9.08e-01	-1.79e-02	9.52e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	8.33e-01	-1.76e-02	9.22e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	72	7.98e-01	-1.75e-02	9.06e-01
SIGNALING BY EGFR IN CANCER	22	8.88e-01	1.74e-02	9.46e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	7.96e-01	1.69e-02	9.06e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	9.10e-01	-1.68e-02	9.52e-01
NOD1 2 SIGNALING PATHWAY	35	8.65e-01	1.66e-02	9.38e-01
SIGNALING BY ERBB2 IN CANCER	25	8.87e-01	1.65e-02	9.46e-01
DAP12 SIGNALING	24	8.90e-01	-1.63e-02	9.46e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	8.93e-01	-1.62e-02	9.46e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	8.83e-01	-1.60e-02	9.45e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	9.32e-01	-1.57e-02	9.64e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	8.48e-01	-1.52e-02	9.25e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	9.09e-01	-1.52e-02	9.52e-01
HIV TRANSCRIPTION ELONGATION	42	8.67e-01	-1.50e-02	9.38e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	67	8.35e-01	-1.47e-02	9.22e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	8.73e-01	-1.45e-02	9.41e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	9.16e-01	-1.44e-02	9.56e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	9.23e-01	1.40e-02	9.60e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	9.40e-01	-1.37e-02	9.70e-01
FGFR2 ALTERNATIVE SPLICING	25	9.06e-01	1.36e-02	9.52e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	9.09e-01	-1.36e-02	9.52e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	78	8.37e-01	1.35e-02	9.22e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	9.21e-01	1.35e-02	9.59e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	32	8.95e-01	-1.35e-02	9.46e-01
SYNDECAN INTERACTIONS	27	9.07e-01	1.30e-02	9.52e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	9.41e-01	1.29e-02	9.70e-01
SIGNALING BY FGFR IN DISEASE	57	8.67e-01	-1.28e-02	9.38e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	9.34e-01	1.27e-02	9.65e-01
SHC MEDIATED CASCADE FGFR1	16	9.31e-01	-1.25e-02	9.64e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	9.09e-01	-1.25e-02	9.52e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	9.48e-01	1.20e-02	9.74e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	26	9.19e-01	1.15e-02	9.59e-01
TP53 REGULATES METABOLIC GENES	85	8.55e-01	-1.14e-02	9.30e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	13	9.43e-01	-1.14e-02	9.71e-01
ION HOMEOSTASIS	50	8.91e-01	-1.12e-02	9.46e-01
SIGNALING BY ROBO RECEPTORS	208	7.84e-01	1.10e-02	8.99e-01
PERK REGULATES GENE EXPRESSION	28	9.20e-01	1.09e-02	9.59e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	12	9.49e-01	-1.06e-02	9.75e-01
METALLOPROTEASE DUBS	27	9.25e-01	1.05e-02	9.61e-01
RHOB GTPASE CYCLE	67	8.83e-01	1.04e-02	9.45e-01
RAC1 GTPASE CYCLE	177	8.17e-01	1.01e-02	9.16e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	9.21e-01	1.01e-02	9.59e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	9.46e-01	-1.00e-02	9.74e-01
DNA DOUBLE STRAND BREAK RESPONSE	55	8.98e-01	1.00e-02	9.47e-01
TRANSCRIPTION OF THE HIV GENOME	67	8.91e-01	9.73e-03	9.46e-01
SENSORY PROCESSING OF SOUND	62	9.03e-01	-8.92e-03	9.52e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	9.33e-01	-8.77e-03	9.65e-01
ESR MEDIATED SIGNALING	172	8.44e-01	8.72e-03	9.24e-01
TRNA PROCESSING	105	8.78e-01	8.70e-03	9.43e-01
ARACHIDONIC ACID METABOLISM	38	9.26e-01	8.67e-03	9.61e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	9.28e-01	-7.76e-03	9.63e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS	163	8.68e-01	-7.58e-03	9.38e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	9.15e-01	7.23e-03	9.56e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	542	7.98e-01	-6.43e-03	9.06e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	9.70e-01	5.99e-03	9.90e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	9.57e-01	-5.72e-03	9.81e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	9.63e-01	5.59e-03	9.85e-01
P75NTR SIGNALS VIA NF KB	15	9.72e-01	-5.17e-03	9.91e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	85	9.38e-01	4.91e-03	9.68e-01
TRANSCRIPTIONAL REGULATION BY TP53	343	8.77e-01	4.85e-03	9.43e-01
SIGNALING BY PDGFR IN DISEASE	20	9.70e-01	-4.78e-03	9.90e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	9.51e-01	-4.74e-03	9.76e-01
RHO GTPASES ACTIVATE PKNS	51	9.56e-01	4.49e-03	9.80e-01
DEVELOPMENTAL BIOLOGY	833	8.29e-01	4.43e-03	9.21e-01
SIGNALLING TO RAS	19	9.76e-01	4.00e-03	9.93e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	9.81e-01	3.69e-03	9.94e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	9.78e-01	3.52e-03	9.94e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	9.79e-01	-3.41e-03	9.94e-01
DISEASES OF PROGRAMMED CELL DEATH	58	9.66e-01	-3.28e-03	9.87e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	9.81e-01	3.27e-03	9.94e-01
AURKA ACTIVATION BY TPX2	71	9.63e-01	-3.16e-03	9.85e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	9.76e-01	3.00e-03	9.93e-01
MISMATCH REPAIR	15	9.85e-01	-2.80e-03	9.95e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	9.87e-01	-2.43e-03	9.95e-01
NUCLEAR IMPORT OF REV PROTEIN	32	9.81e-01	2.37e-03	9.94e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	9.86e-01	2.28e-03	9.95e-01
RUNX2 REGULATES BONE DEVELOPMENT	29	9.87e-01	-1.70e-03	9.95e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	9.82e-01	1.69e-03	9.94e-01
PECAM1 INTERACTIONS	12	9.92e-01	1.61e-03	9.99e-01
ION TRANSPORT BY P TYPE ATPASES	50	9.88e-01	-1.27e-03	9.95e-01
REPRESSION OF WNT TARGET GENES	14	9.94e-01	-1.11e-03	1.00e+00
PYRIMIDINE CATABOLISM	10	9.95e-01	1.09e-03	1.00e+00
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	64	9.96e-01	-3.96e-04	1.00e+00
PLASMA LIPOPROTEIN REMODELING	14	9.99e-01	-2.36e-04	1.00e+00
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	9.98e-01	-2.15e-04	1.00e+00
SIGNALING BY NOTCH3	48	9.98e-01	-1.97e-04	1.00e+00
CELLULAR SENESCENCE	146	9.99e-01	8.71e-05	1.00e+00
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	1.00e+00	1.63e-05	1.00e+00

Detailed Gene set reports

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
	340
set	FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize	19
pANOVA	9.33e-08
s.dist	0.707
p.adjustANOVA	5.5e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cct6a	8139
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Cct5	7328
Tuba4a	7208
Cct3	7150
Tuba1a	7067
Tcp1	6639
Cct8	6486
Cct4	6252
Tubb3	5842
Cct7	4843
Tuba1c	4485
Cct2	3832
Tubb6	1806
Tuba8	-5577

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cct6a	8139
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Cct5	7328
Tuba4a	7208
Cct3	7150
Tuba1a	7067
Tcp1	6639
Cct8	6486
Cct4	6252
Tubb3	5842
Cct7	4843
Tuba1c	4485
Cct2	3832
Tubb6	1806
Tuba8	-5577

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
	47
set	ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize	12
pANOVA	0.000265
s.dist	0.608
p.adjustANOVA	0.004

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fads2	8315
Fads1	8229
Elovl1	7473
Hsd17b4	6568
Acox1	6066
Acaa1a	5291
Scp2	3811
Acot8	3545
Acsl1	2715
Elovl5	2632
Elovl2	2613
Abcd1	1865

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fads2	8315
Fads1	8229
Elovl1	7473
Hsd17b4	6568
Acox1	6066
Acaa1a	5291
Scp2	3811
Acot8	3545
Acsl1	2715
Elovl5	2632
Elovl2	2613
Abcd1	1865

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION

GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
	398
set	GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION
setSize	12
pANOVA	0.000567
s.dist	0.575
p.adjustANOVA	0.00704

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mapk3	7701
Gorasp2	7540
Mapk1	7097
Uso1	6853
Rab2a	6470
Rab1b	6316
Rab1a	6145
Ccnb2	5891
Blzf1	4985
Gorasp1	4112
Golga2	-3175
Plk1	-4344

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mapk3	7701
Gorasp2	7540
Mapk1	7097
Uso1	6853
Rab2a	6470
Rab1b	6316
Rab1a	6145
Ccnb2	5891
Blzf1	4985
Gorasp1	4112
Golga2	-3175
Plk1	-4344

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
	757
set	PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
setSize	12
pANOVA	0.000789
s.dist	0.56
p.adjustANOVA	0.00911

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Impdh2	7591
Gart	7383
Paics	7071
Adss	6927
Gmps	6784
Atic	6715
Adsl	5423
Adssl1	5346
Impdh1	3125
Ppat	1917
Lhpp	1163
Pfas	-5437

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Impdh2	7591
Gart	7383
Paics	7071
Adss	6927
Gmps	6784
Atic	6715
Adsl	5423
Adssl1	5346
Impdh1	3125
Ppat	1917
Lhpp	1163
Pfas	-5437

RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
	860
set	RHOBTB3 ATPASE CYCLE
setSize	10
pANOVA	0.00245
s.dist	0.553
p.adjustANOVA	0.021

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Htr7	7894
Ccne1	7431
Rab9b	5924
Cul3	5822
Hgs	5340
Plin3	5265
Lrrc41	4586
Vhl	2253
Rhobtb3	402
Rab9	-457

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Htr7	7894
Ccne1	7431
Rab9b	5924
Cul3	5822
Hgs	5340
Plin3	5265
Lrrc41	4586
Vhl	2253
Rhobtb3	402
Rab9	-457

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE

TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
	1138
set	TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE
setSize	13
pANOVA	0.000836
s.dist	0.535
p.adjustANOVA	0.00938

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Tubb3	5842
Gja1	5105
Tuba1c	4485
Tubb6	1806
Tuba8	-5577
Gjb2	-8878

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Tubb3	5842
Gja1	5105
Tuba1c	4485
Tubb6	1806
Tuba8	-5577
Gjb2	-8878

BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM
	92
set	BBSOME MEDIATED CARGO TARGETING TO CILIUM
setSize	23
pANOVA	9.28e-06
s.dist	0.534
p.adjustANOVA	0.00028

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mkks	8028
Bbs10	7881
Cct5	7328
Mchr1	7255
Bbs9	7234
Cct3	7150
Arl6	6976
Tcp1	6639
Lztfl1	6504
Cct8	6486
Cct4	6252
Rab3ip	6224
Ttc8	6172
Bbs1	5926
Smo	5053
Bbs7	4516
Cct2	3832
Bbs2	2160
Bbip1	1835
Bbs4	1657

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mkks	8028
Bbs10	7881
Cct5	7328
Mchr1	7255
Bbs9	7234
Cct3	7150
Arl6	6976
Tcp1	6639
Lztfl1	6504
Cct8	6486
Cct4	6252
Rab3ip	6224
Ttc8	6172
Bbs1	5926
Smo	5053
Bbs7	4516
Cct2	3832
Bbs2	2160
Bbip1	1835
Bbs4	1657
Sstr3	-5368
Bbs5	-5698
Bbs12	-5783

CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
	154
set	CITRIC ACID CYCLE TCA CYCLE
setSize	22
pANOVA	2.49e-05
s.dist	0.519
p.adjustANOVA	0.000636

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Idh2	8249
Idh3a	7988
Fh1	7915
Sucla2	6928
Dld	6906
Idh3b	6659
Dlst	6472
Suclg2	5337
Mdh2	5325
Sdhd	5079
Aco2	4730
Idh3g	4298
Sdha	4003
Cs	3839
Ogdh	3656
Suclg1	3555
Nnt	3360
Sdhb	2165
Fahd1	1729
Sdhc	1198

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Idh2	8249
Idh3a	7988
Fh1	7915
Sucla2	6928
Dld	6906
Idh3b	6659
Dlst	6472
Suclg2	5337
Mdh2	5325
Sdhd	5079
Aco2	4730
Idh3g	4298
Sdha	4003
Cs	3839
Ogdh	3656
Suclg1	3555
Nnt	3360
Sdhb	2165
Fahd1	1729
Sdhc	1198
Me2	-3407
Me3	-4847

NUCLEOBASE BIOSYNTHESIS

NUCLEOBASE BIOSYNTHESIS
	655
set	NUCLEOBASE BIOSYNTHESIS
setSize	15
pANOVA	0.000668
s.dist	0.507
p.adjustANOVA	0.00803

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Umps	7689
Impdh2	7591
Gart	7383
Paics	7071
Adss	6927
Gmps	6784
Atic	6715
Adsl	5423
Adssl1	5346
Impdh1	3125
Ppat	1917
Lhpp	1163
Dhodh	1010
Cad	-2095
Pfas	-5437

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Umps	7689
Impdh2	7591
Gart	7383
Paics	7071
Adss	6927
Gmps	6784
Atic	6715
Adsl	5423
Adssl1	5346
Impdh1	3125
Ppat	1917
Lhpp	1163
Dhodh	1010
Cad	-2095
Pfas	-5437

KERATAN SULFATE BIOSYNTHESIS

KERATAN SULFATE BIOSYNTHESIS
	505
set	KERATAN SULFATE BIOSYNTHESIS
setSize	24
pANOVA	2.54e-05
s.dist	0.497
p.adjustANOVA	0.000636

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prelp	8307
B4galt4	8133
B4gat1	7867
B4galt1	7206
B4galt2	7053
Chst2	6910
B3gnt2	6456
Chst1	5732
St3gal4	5412
Acan	5261
St3gal2	4804
B4galt6	4181
B3gnt4	4171
Fmod	4018
Lum	3386
Slc35d2	3267
B3gnt7	2820
St3gal1	2423
B4galt3	2030
St3gal3	1871

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prelp	8307
B4galt4	8133
B4gat1	7867
B4galt1	7206
B4galt2	7053
Chst2	6910
B3gnt2	6456
Chst1	5732
St3gal4	5412
Acan	5261
St3gal2	4804
B4galt6	4181
B3gnt4	4171
Fmod	4018
Lum	3386
Slc35d2	3267
B3gnt7	2820
St3gal1	2423
B4galt3	2030
St3gal3	1871
B4galt5	1637
Chst5	1487
Ogn	-1934
St3gal6	-7863

COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC

COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
	182
set	COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC
setSize	44
pANOVA	1.48e-08
s.dist	0.493
p.adjustANOVA	1.16e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Capza2	7704
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Actr1a	7389
Capza1	7253
Tuba4a	7208
Dctn4	7177
Tuba1a	7067
Rab6a	6581
Rab18	6537
Dctn6	6465
Dctn1	6188
Rab3gap1	6072
Tubb3	5842
Dync1i1	5759
Pla2g6	5480
Dctn5	5433

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Capza2	7704
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Actr1a	7389
Capza1	7253
Tuba4a	7208
Dctn4	7177
Tuba1a	7067
Rab6a	6581
Rab18	6537
Dctn6	6465
Dctn1	6188
Rab3gap1	6072
Tubb3	5842
Dync1i1	5759
Pla2g6	5480
Dctn5	5433
Rab6b	5302
Capzb	5208
Pla2g4a	4647
Tuba1c	4485
Galnt1	4231
Dynll1	3613
Dctn2	3314
Actr10	2962
Pafah1b3	2884
Galnt2	2757
Dync1li1	2623
Pafah1b1	2584
Pafah1b2	2292
Rab3gap2	2191
Agpat3	1986
Tubb6	1806
Dync1h1	1341
Dctn3	329
Bicd2	-362
Dynll2	-1891
Dync1li2	-3541
Dync1i2	-3902
Bicd1	-3999
Tuba8	-5577

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
	180
set	COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize	26
pANOVA	2.52e-05
s.dist	0.477
p.adjustANOVA	0.000636

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cct6a	8139
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Cct5	7328
Tuba4a	7208
Cct3	7150
Tuba1a	7067
Tcp1	6639
Cct8	6486
Cct4	6252
Tubb3	5842
Cct7	4843
Pfdn4	4529
Tuba1c	4485
Cct2	3832
Vbp1	3176
Tubb6	1806

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cct6a	8139
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Cct5	7328
Tuba4a	7208
Cct3	7150
Tuba1a	7067
Tcp1	6639
Cct8	6486
Cct4	6252
Tubb3	5842
Cct7	4843
Pfdn4	4529
Tuba1c	4485
Cct2	3832
Vbp1	3176
Tubb6	1806
Pfdn1	574
Pfdn5	-3196
Pfdn6	-3809
Pfdn2	-4915
Tuba8	-5577
Actb	-8390

HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR

HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
	435
set	HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR
setSize	48
pANOVA	2.46e-08
s.dist	0.465
p.adjustANOVA	1.7e-06

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspa2	8280
Hspa1b	8162
Tubb2a	8130
Dnaja2	7983
Tuba1b	7873
Capza2	7704
Tubb4b	7622
Dnaja4	7556
Tubb4a	7517
Tubb2b	7504
Actr1a	7389
Dnaja1	7327
Capza1	7253
Tuba4a	7208
Dctn4	7177
Tuba1a	7067
Stip1	6832
Dctn6	6465
Dctn1	6188
Fkbp5	5985

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspa2	8280
Hspa1b	8162
Tubb2a	8130
Dnaja2	7983
Tuba1b	7873
Capza2	7704
Tubb4b	7622
Dnaja4	7556
Tubb4a	7517
Tubb2b	7504
Actr1a	7389
Dnaja1	7327
Capza1	7253
Tuba4a	7208
Dctn4	7177
Tuba1a	7067
Stip1	6832
Dctn6	6465
Dctn1	6188
Fkbp5	5985
Tubb3	5842
Dync1i1	5759
Fkbp4	5611
Dctn5	5433
Capzb	5208
Hspa8	5004
Tuba1c	4485
Dynll1	3613
Ptges3	3550
Dctn2	3314
Actr10	2962
Dync1li1	2623
Nr3c2	2400
Tubb6	1806
Dnajb1	1793
Dync1h1	1341
Dctn3	329
Ar	266
Nr3c1	-1009
Dynll2	-1891
Hsp90ab1	-2348
Hspa1l	-2920
Hsp90aa1	-2970
Pgr	-3538
Dync1li2	-3541
Dync1i2	-3902
Hspa1a	-5092
Tuba8	-5577

KERATAN SULFATE KERATIN METABOLISM

KERATAN SULFATE KERATIN METABOLISM
	507
set	KERATAN SULFATE KERATIN METABOLISM
setSize	30
pANOVA	1.46e-05
s.dist	0.457
p.adjustANOVA	0.000409

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prelp	8307
B4galt4	8133
B4gat1	7867
B4galt1	7206
B4galt2	7053
Chst2	6910
B3gnt2	6456
Chst1	5732
Hexa	5632
St3gal4	5412
Acan	5261
St3gal2	4804
Gns	4656
Hexb	4301
B4galt6	4181
B3gnt4	4171
Fmod	4018
Lum	3386
Slc35d2	3267
B3gnt7	2820

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prelp	8307
B4galt4	8133
B4gat1	7867
B4galt1	7206
B4galt2	7053
Chst2	6910
B3gnt2	6456
Chst1	5732
Hexa	5632
St3gal4	5412
Acan	5261
St3gal2	4804
Gns	4656
Hexb	4301
B4galt6	4181
B3gnt4	4171
Fmod	4018
Lum	3386
Slc35d2	3267
B3gnt7	2820
St3gal1	2423
Glb1	2200
B4galt3	2030
St3gal3	1871
B4galt5	1637
Chst5	1487
Glb1l	552
Ogn	-1934
Galns	-4080
St3gal6	-7863

CALNEXIN CALRETICULIN CYCLE

CALNEXIN CALRETICULIN CYCLE
	110
set	CALNEXIN CALRETICULIN CYCLE
setSize	26
pANOVA	5.9e-05
s.dist	0.455
p.adjustANOVA	0.0012

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Calr	8220
Derl2	8209
Pdia3	7888
Prkcsh	7715
Ganab	7291
Rnf185	6706
Os9	6588
Canx	6365
Man1b1	6134
Marchf6	5839
Rnf5	5661
Edem2	5636
Amfr	5428
Rnf139	5303
Uggt1	5299
Syvn1	5168
Ubc	4500
Edem3	2269
Ubb	1303
Rps27a	-478

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Calr	8220
Derl2	8209
Pdia3	7888
Prkcsh	7715
Ganab	7291
Rnf185	6706
Os9	6588
Canx	6365
Man1b1	6134
Marchf6	5839
Rnf5	5661
Edem2	5636
Amfr	5428
Rnf139	5303
Uggt1	5299
Syvn1	5168
Ubc	4500
Edem3	2269
Ubb	1303
Rps27a	-478
Rnf103	-721
Edem1	-1059
Sel1l	-2256
Uggt2	-2738
Trim13	-3011
Uba52	-8214

GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
	391
set	GLYCOGEN STORAGE DISEASES
setSize	12
pANOVA	0.00644
s.dist	0.454
p.adjustANOVA	0.0424

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gyg	7709
Gaa	7535
Gbe1	7309
Nhlrc1	6939
G6pc3	6444
Epm2a	5095
Ubc	4500
Ppp1r3c	2878
Gys1	1875
Ubb	1303
Rps27a	-478
Uba52	-8214

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gyg	7709
Gaa	7535
Gbe1	7309
Nhlrc1	6939
G6pc3	6444
Epm2a	5095
Ubc	4500
Ppp1r3c	2878
Gys1	1875
Ubb	1303
Rps27a	-478
Uba52	-8214

GAP JUNCTION ASSEMBLY

GAP JUNCTION ASSEMBLY
	371
set	GAP JUNCTION ASSEMBLY
setSize	21
pANOVA	0.000314
s.dist	0.454
p.adjustANOVA	0.00462

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Gjb6	7577
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Gjd2	6953
Gjd3	5958
Tubb3	5842
Gja1	5105
Tuba1c	4485
Gjb1	3853
Gjc1	2485
Tubb6	1806
Gjc2	1414
Gja4	-1332
Tuba8	-5577
Gja5	-7589

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Gjb6	7577
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Gjd2	6953
Gjd3	5958
Tubb3	5842
Gja1	5105
Tuba1c	4485
Gjb1	3853
Gjc1	2485
Tubb6	1806
Gjc2	1414
Gja4	-1332
Tuba8	-5577
Gja5	-7589
Gjb2	-8878

ENDOSOMAL VACUOLAR PATHWAY

ENDOSOMAL VACUOLAR PATHWAY
	284
set	ENDOSOMAL VACUOLAR PATHWAY
setSize	10
pANOVA	0.0131
s.dist	-0.453
p.adjustANOVA	0.0681

Top enriched genes

Top 20 genes
GeneID	Gene Rank
H2-T23	-9188
H2-M3	-8824
H2-Q7	-7765
B2m	-7131
H2-Q10	-6983
H2-D1	-5043
Lnpep	-4287
H2-Q2	-2917
Ctss	2781
Ctsl	5335

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
H2-T23	-9188
H2-M3	-8824
H2-Q7	-7765
B2m	-7131
H2-Q10	-6983
H2-D1	-5043
Lnpep	-4287
H2-Q2	-2917
Ctss	2781
Ctsl	5335

RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
	842
set	RETROGRADE NEUROTROPHIN SIGNALLING
setSize	13
pANOVA	0.00477
s.dist	0.452
p.adjustANOVA	0.0339

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ap2m1	7792
Dnm2	7614
Ap2b1	7522
Dnal4	7381
Ap2a2	6984
Ap2a1	6110
Cltc	4483
Clta	3556
Sh3gl2	2855
Dnm3	2297
Dnm1	814
Ap2s1	-3475
Ntrk1	-7720

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ap2m1	7792
Dnm2	7614
Ap2b1	7522
Dnal4	7381
Ap2a2	6984
Ap2a1	6110
Cltc	4483
Clta	3556
Sh3gl2	2855
Dnm3	2297
Dnm1	814
Ap2s1	-3475
Ntrk1	-7720

GLYCOGEN SYNTHESIS

GLYCOGEN SYNTHESIS
	392
set	GLYCOGEN SYNTHESIS
setSize	14
pANOVA	0.00363
s.dist	0.449
p.adjustANOVA	0.0274

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pgm1	8318
Ugp2	8093
Gyg	7709
Gbe1	7309
Nhlrc1	6939
Pgm2	6644
Epm2a	5095
Ubc	4500
Ppp1r3c	2878
Gys1	1875
Ubb	1303
Rps27a	-478
Pgm2l1	-2578
Uba52	-8214

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pgm1	8318
Ugp2	8093
Gyg	7709
Gbe1	7309
Nhlrc1	6939
Pgm2	6644
Epm2a	5095
Ubc	4500
Ppp1r3c	2878
Gys1	1875
Ubb	1303
Rps27a	-478
Pgm2l1	-2578
Uba52	-8214

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III

SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
	909
set	SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III
setSize	23
pANOVA	0.000265
s.dist	0.439
p.adjustANOVA	0.004

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Vps4a	7252
Tuba4a	7208
Chmp7	7151
Chmp3	7107
Tuba1a	7067
Chmp2b	6346
Chmp4b	6041
Spast	5925
Tubb3	5842
Tuba1c	4485
Tubb6	1806
Chmp6	1720
Lemd2	-1060
Chmp2a	-2646
Ist1	-4378

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Vps4a	7252
Tuba4a	7208
Chmp7	7151
Chmp3	7107
Tuba1a	7067
Chmp2b	6346
Chmp4b	6041
Spast	5925
Tubb3	5842
Tuba1c	4485
Tubb6	1806
Chmp6	1720
Lemd2	-1060
Chmp2a	-2646
Ist1	-4378
Cc2d1b	-5268
Tuba8	-5577
Chmp4c	-8521

LDL CLEARANCE

LDL CLEARANCE
	516
set	LDL CLEARANCE
setSize	16
pANOVA	0.00246
s.dist	0.437
p.adjustANOVA	0.021

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Lipa	8232
Ap2m1	7792
Ap2b1	7522
Npc1	7221
Ap2a2	6984
Soat1	6714
Ap2a1	6110
Nceh1	5557
Cltc	4483
Clta	3556
Ldlr	1991
Npc2	1627
Lsr	745
Ap2s1	-3475
Pcsk9	-4163
Ldlrap1	-6117

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Lipa	8232
Ap2m1	7792
Ap2b1	7522
Npc1	7221
Ap2a2	6984
Soat1	6714
Ap2a1	6110
Nceh1	5557
Cltc	4483
Clta	3556
Ldlr	1991
Npc2	1627
Lsr	745
Ap2s1	-3475
Pcsk9	-4163
Ldlrap1	-6117

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
	146
set	CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize	10
pANOVA	0.0169
s.dist	0.436
p.adjustANOVA	0.08

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sfn	6246
Chek1	6044
Ywhaq	5968
Ywhab	4891
Ywhah	3722
Wee1	3716
Ywhae	2826
Ywhaz	1182
Ywhag	961
Chek2	-1400

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sfn	6246
Chek1	6044
Ywhaq	5968
Ywhab	4891
Ywhah	3722
Wee1	3716
Ywhae	2826
Ywhaz	1182
Ywhag	961
Chek2	-1400

OLFACTORY SIGNALING PATHWAY

OLFACTORY SIGNALING PATHWAY
	664
set	OLFACTORY SIGNALING PATHWAY
setSize	40
pANOVA	2.56e-06
s.dist	-0.43
p.adjustANOVA	0.000112

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rtp4	-9185
Olfr981	-9130
Olfr354	-9066
Olfr635	-8967
Olfr1310	-8891
Olfr1192-ps1	-8827
Olfr796	-8547
Olfr1564	-8513
Olfr2	-8472
Olfr735	-8412
Olfr63	-8335
Olfr1309	-8324
Olfr986	-8079
Olfr287	-7681
Olfr90	-7344
Olfr78	-7306
Olfr31	-6758
Olfr804	-6712
Gng13	-6622
Olfr1385	-6534

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rtp4	-9185
Olfr981	-9130
Olfr354	-9066
Olfr635	-8967
Olfr1310	-8891
Olfr1192-ps1	-8827
Olfr796	-8547
Olfr1564	-8513
Olfr2	-8472
Olfr735	-8412
Olfr63	-8335
Olfr1309	-8324
Olfr986	-8079
Olfr287	-7681
Olfr90	-7344
Olfr78	-7306
Olfr31	-6758
Olfr804	-6712
Gng13	-6622
Olfr1385	-6534
Olfr161	-5851
Olfr365	-5455
Olfr137	-5449
Olfr713	-5014
Reep4	-4431
Olfr648	-4383
Olfr147	-3210
Olfr558	-2465
Olfr1507	-587
Reep6	-581
Reep3	-347
Olfr446	176
Olfr95	313
Olfr552	353
Reep1	2405
Gnal	4239
Reep2	5124
Olfr464	6000
Gnb1	6352
Reep5	6884

RHO GTPASES ACTIVATE IQGAPS

RHO GTPASES ACTIVATE IQGAPS
	848
set	RHO GTPASES ACTIVATE IQGAPS
setSize	23
pANOVA	0.000381
s.dist	0.428
p.adjustANOVA	0.00521

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Ctnna1	7489
Tuba4a	7208
Tuba1a	7067
Ctnnb1	6810
Men1	6234
Rac1	6022
Tubb3	5842
Tuba1c	4485
Cdc42	3640
Iqgap2	2145
Actg1	1983
Tubb6	1806
Calm1	451
Iqgap1	-602
Cdh1	-3096

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Ctnna1	7489
Tuba4a	7208
Tuba1a	7067
Ctnnb1	6810
Men1	6234
Rac1	6022
Tubb3	5842
Tuba1c	4485
Cdc42	3640
Iqgap2	2145
Actg1	1983
Tubb6	1806
Calm1	451
Iqgap1	-602
Cdh1	-3096
Clip1	-5312
Tuba8	-5577
Actb	-8390

RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY
	777
set	RECEPTOR MEDIATED MITOPHAGY
setSize	11
pANOVA	0.0149
s.dist	0.424
p.adjustANOVA	0.0749

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fundc1	6709
Atg12	6464
Csnk2a2	5876
Csnk2b	5064
Ulk1	4360
Map1lc3b	3536
Src	2551
Pgam5	2243
Atg5	1480
Map1lc3a	861
Csnk2a1	-2742

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fundc1	6709
Atg12	6464
Csnk2a2	5876
Csnk2b	5064
Ulk1	4360
Map1lc3b	3536
Src	2551
Pgam5	2243
Atg5	1480
Map1lc3a	861
Csnk2a1	-2742

PURINE SALVAGE

PURINE SALVAGE
	758
set	PURINE SALVAGE
setSize	12
pANOVA	0.0114
s.dist	0.422
p.adjustANOVA	0.0622

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Adk	6834
Pnp2	6409
Gmpr2	6404
Dck	6351
Dguok	5001
Hprt	4960
Gmpr	3868
Adal	3166
Ampd3	2029
Ampd2	746
Ada	-2926
Aprt	-3368

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Adk	6834
Pnp2	6409
Gmpr2	6404
Dck	6351
Dguok	5001
Hprt	4960
Gmpr	3868
Adal	3166
Ampd3	2029
Ampd2	746
Ada	-2926
Aprt	-3368

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
	595
set	N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
setSize	35
pANOVA	1.74e-05
s.dist	0.42
p.adjustANOVA	0.000475

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Calr	8220
Derl2	8209
Pdia3	7888
Ngly1	7717
Prkcsh	7715
Mlec	7562
Vcp	7408
Ganab	7291
Rnf185	6706
Os9	6588
Derl1	6478
Canx	6365
Man1b1	6134
Marchf6	5839
Rnf5	5661
Edem2	5636
Amfr	5428
Rnf139	5303
Uggt1	5299
Syvn1	5168

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Calr	8220
Derl2	8209
Pdia3	7888
Ngly1	7717
Prkcsh	7715
Mlec	7562
Vcp	7408
Ganab	7291
Rnf185	6706
Os9	6588
Derl1	6478
Canx	6365
Man1b1	6134
Marchf6	5839
Rnf5	5661
Edem2	5636
Amfr	5428
Rnf139	5303
Uggt1	5299
Syvn1	5168
Ubc	4500
Rad23b	3835
Edem3	2269
Ubb	1303
Psmc1	753
Rps27a	-478
Rnf103	-721
Edem1	-1059
Ubxn1	-2035
Sel1l	-2256
Uggt2	-2738
Trim13	-3011
Mogs	-3451
Engase	-7024
Uba52	-8214

CD28 DEPENDENT VAV1 PATHWAY

CD28 DEPENDENT VAV1 PATHWAY
	125
set	CD28 DEPENDENT VAV1 PATHWAY
setSize	11
pANOVA	0.0164
s.dist	0.418
p.adjustANOVA	0.0789

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cd86	6435
Pak1	6372
Rac1	6022
Pak2	5893
Fyn	4408
Cdc42	3640
Pak3	3584
Lck	3286
Vav1	1300
Grb2	-450
Cd80	-4688

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cd86	6435
Pak1	6372
Rac1	6022
Pak2	5893
Fyn	4408
Cdc42	3640
Pak3	3584
Lck	3286
Vav1	1300
Grb2	-450
Cd80	-4688

ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING

ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING
	43
set	ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING
setSize	11
pANOVA	0.0165
s.dist	0.417
p.adjustANOVA	0.0789

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkcsh	7715
Capza2	7704
Mapk3	7701
Capza1	7253
Mapk1	7097
Ddost	5927
App	5597
Hmgb1	-1491
Ager	-2689
Lgals3	-3826
S100b	-5232

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkcsh	7715
Capza2	7704
Mapk3	7701
Capza1	7253
Mapk1	7097
Ddost	5927
App	5597
Hmgb1	-1491
Ager	-2689
Lgals3	-3826
S100b	-5232

N GLYCAN ANTENNAE ELONGATION

N GLYCAN ANTENNAE ELONGATION
	593
set	N GLYCAN ANTENNAE ELONGATION
setSize	15
pANOVA	0.00519
s.dist	0.417
p.adjustANOVA	0.0356

Top enriched genes

Top 20 genes
GeneID	Gene Rank
B4galt4	8133
B4galt1	7206
B4galt2	7053
St8sia3	5894
St3gal4	5412
B4galt6	4181
St8sia2	3411
Mgat4b	3296
B4galt3	2030
B4galt5	1637
St8sia6	1391
Mgat4c	919
Mgat4a	5
St6gal1	-307
Mgat5	-1593

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
B4galt4	8133
B4galt1	7206
B4galt2	7053
St8sia3	5894
St3gal4	5412
B4galt6	4181
St8sia2	3411
Mgat4b	3296
B4galt3	2030
B4galt5	1637
St8sia6	1391
Mgat4c	919
Mgat4a	5
St6gal1	-307
Mgat5	-1593

TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX

TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
	1129
set	TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
setSize	12
pANOVA	0.0124
s.dist	0.417
p.adjustANOVA	0.0654

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Chmp7	7151
Chmp3	7107
Chmp2b	6346
Becn1	6136
Chmp4b	6041
Uvrag	5912
Pik3c3	3997
Map1lc3b	3536
Pik3r4	2154
Chmp6	1720
Chmp2a	-2646
Chmp4c	-8521

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Chmp7	7151
Chmp3	7107
Chmp2b	6346
Becn1	6136
Chmp4b	6041
Uvrag	5912
Pik3c3	3997
Map1lc3b	3536
Pik3r4	2154
Chmp6	1720
Chmp2a	-2646
Chmp4c	-8521

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2

WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
	1173
set	WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2
setSize	13
pANOVA	0.00963
s.dist	0.415
p.adjustANOVA	0.0544

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fzd2	8203
Ap2m1	7792
Ap2b1	7522
Ap2a2	6984
Fzd5	6688
Ap2a1	6110
Cltc	4483
Clta	3556
Ror2	3167
Cltb	3123
Ap2s1	-3475
Wnt5a	-5644
Ror1	-6564

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fzd2	8203
Ap2m1	7792
Ap2b1	7522
Ap2a2	6984
Fzd5	6688
Ap2a1	6110
Cltc	4483
Clta	3556
Ror2	3167
Cltb	3123
Ap2s1	-3475
Wnt5a	-5644
Ror1	-6564

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
	1049
set	SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
setSize	10
pANOVA	0.0235
s.dist	0.414
p.adjustANOVA	0.1

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Itpk1	7922
Nudt11	7798
Ip6k3	7087
Nudt10	5333
Nudt4	3963
Ip6k1	2822
Nudt3	2741
Ippk	610
Ppip5k1	-2554
Ppip5k2	-3534

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Itpk1	7922
Nudt11	7798
Ip6k3	7087
Nudt10	5333
Nudt4	3963
Ip6k1	2822
Nudt3	2741
Ippk	610
Ppip5k1	-2554
Ppip5k2	-3534

GLYCOGEN METABOLISM

GLYCOGEN METABOLISM
	390
set	GLYCOGEN METABOLISM
setSize	25
pANOVA	0.000353
s.dist	0.413
p.adjustANOVA	0.00501

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pgm1	8318
Ugp2	8093
Gyg	7709
Gaa	7535
Pygb	7372
Gbe1	7309
Nhlrc1	6939
Pygm	6866
Pgm2	6644
Phkb	5292
Epm2a	5095
Ubc	4500
Phka1	3669
Ppp1r3c	2878
Gys1	1875
Phkg1	1377
Phkg2	1354
Ubb	1303
Agl	1034
Calm1	451

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pgm1	8318
Ugp2	8093
Gyg	7709
Gaa	7535
Pygb	7372
Gbe1	7309
Nhlrc1	6939
Pygm	6866
Pgm2	6644
Phkb	5292
Epm2a	5095
Ubc	4500
Phka1	3669
Ppp1r3c	2878
Gys1	1875
Phkg1	1377
Phkg2	1354
Ubb	1303
Agl	1034
Calm1	451
Rps27a	-478
Phka2	-1545
Pgm2l1	-2578
Pygl	-2603
Uba52	-8214

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS

REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
	824
set	REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS
setSize	14
pANOVA	0.00818
s.dist	0.408
p.adjustANOVA	0.0492

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pou4f1	7924
Banp	7905
Trp73	7773
Ppp1r13b	7716
Pou4f2	5931
Ppp1r13l	4079
Trp53	3770
Akt1	2876
Zfp385a	2516
Phf20	1127
Akt3	-553
Akt2	-867
Trp53bp2	-1465
Trp63	-4363

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pou4f1	7924
Banp	7905
Trp73	7773
Ppp1r13b	7716
Pou4f2	5931
Ppp1r13l	4079
Trp53	3770
Akt1	2876
Zfp385a	2516
Phf20	1127
Akt3	-553
Akt2	-867
Trp53bp2	-1465
Trp63	-4363

CYTOSOLIC TRNA AMINOACYLATION

CYTOSOLIC TRNA AMINOACYLATION
	204
set	CYTOSOLIC TRNA AMINOACYLATION
setSize	24
pANOVA	0.000542
s.dist	0.408
p.adjustANOVA	0.00694

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hars	8296
Rars	7470
Aimp2	7422
Farsb	7200
Ppa1	7100
Eef1e1	6693
Yars	6613
Mars1	6307
Wars	6255
Aars	5085
Iars	5037
Qars	4241
Gars	3840
Dars	3101
Kars	2794
Nars	1886
Lars	954
Aimp1	-438
Tars	-1336
Cars	-1854

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hars	8296
Rars	7470
Aimp2	7422
Farsb	7200
Ppa1	7100
Eef1e1	6693
Yars	6613
Mars1	6307
Wars	6255
Aars	5085
Iars	5037
Qars	4241
Gars	3840
Dars	3101
Kars	2794
Nars	1886
Lars	954
Aimp1	-438
Tars	-1336
Cars	-1854
Sars	-2074
Eprs	-2545
Vars	-2868
Farsa	-3226

INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE

INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
	455
set	INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE
setSize	22
pANOVA	0.000958
s.dist	0.407
p.adjustANOVA	0.0105

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Get1	8075
Stx1a	7268
Prnp	7171
Get3	7133
Bag6	5899
App	5597
Ubl4a	5381
Sgta	5139
Cyb5a	5083
Vamp2	4705
Emd	4453
Serp1	4344
Vapa	3068
Sec61g	2203
Hmox1	1080
Stx5a	589
Caml	501
Otof	-913
Get4	-945
Sec61b	-1209

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Get1	8075
Stx1a	7268
Prnp	7171
Get3	7133
Bag6	5899
App	5597
Ubl4a	5381
Sgta	5139
Cyb5a	5083
Vamp2	4705
Emd	4453
Serp1	4344
Vapa	3068
Sec61g	2203
Hmox1	1080
Stx5a	589
Caml	501
Otof	-913
Get4	-945
Sec61b	-1209
Aldh3a2	-2412
Ube2j2	-2804

GLYCOSPHINGOLIPID METABOLISM

GLYCOSPHINGOLIPID METABOLISM
	395
set	GLYCOSPHINGOLIPID METABOLISM
setSize	38
pANOVA	1.44e-05
s.dist	0.407
p.adjustANOVA	0.000409

Top enriched genes

Top 20 genes
GeneID	Gene Rank
B3galnt1	8049
B4galnt1	7752
Ugt8a	7448
Galc	7210
Neu2	7012
Smpd1	6878
Gba2	6789
Arsa	6740
Arsb	6727
Neu1	6712
Asah1	6628
Esyt1	6584
Gltp	6313
Gm2a	6086
Neu4	5752
Psap	5640
Hexa	5632
Gba	5555
Gla	4912
Hexb	4301

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
B3galnt1	8049
B4galnt1	7752
Ugt8a	7448
Galc	7210
Neu2	7012
Smpd1	6878
Gba2	6789
Arsa	6740
Arsb	6727
Neu1	6712
Asah1	6628
Esyt1	6584
Gltp	6313
Gm2a	6086
Neu4	5752
Psap	5640
Hexa	5632
Gba	5555
Gla	4912
Hexb	4301
Smpd3	4201
Ugcg	2966
Neu3	2480
Sumf1	2210
Glb1	2200
Sumf2	2175
Arsk	1769
Glb1l	552
Esyt3	-116
Cptp	-917
Smpd4	-2131
Ctsa	-2132
Arsj	-2309
Asah2	-2426
Smpd2	-2819
Arsg	-3310
Cerk	-4543
Esyt2	-6870

WNT LIGAND BIOGENESIS AND TRAFFICKING

WNT LIGAND BIOGENESIS AND TRAFFICKING
	1172
set	WNT LIGAND BIOGENESIS AND TRAFFICKING
setSize	21
pANOVA	0.00161
s.dist	0.398
p.adjustANOVA	0.0157

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Wnt11	8332
Wls	8074
Wnt9b	7248
Snx3	7021
Vps35	6713
Vps26a	4676
Wnt7b	4599
Vps29	4572
Wnt9a	3777
Wnt3	3484
Wnt10a	2478
Wnt2b	2458
Wnt2	2439
Wnt7a	2245
Wnt4	1511
Wnt16	1064
Porcn	771
Tmed5	170
Wnt5b	161
Wnt6	-1598

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Wnt11	8332
Wls	8074
Wnt9b	7248
Snx3	7021
Vps35	6713
Vps26a	4676
Wnt7b	4599
Vps29	4572
Wnt9a	3777
Wnt3	3484
Wnt10a	2478
Wnt2b	2458
Wnt2	2439
Wnt7a	2245
Wnt4	1511
Wnt16	1064
Porcn	771
Tmed5	170
Wnt5b	161
Wnt6	-1598
Wnt5a	-5644

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
	1051
set	SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize	20
pANOVA	0.00211
s.dist	0.397
p.adjustANOVA	0.0191

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acsl4	7747
Acsbg1	7636
Hsd17b12	7631
Elovl1	7473
Tecr	7018
Hacd2	6515
Acsl6	6049
Hacd3	5881
Elovl4	5850
Acsl5	4917
Acsl3	4277
Elovl6	2861
Acsl1	2715
Elovl5	2632
Elovl2	2613
Slc27a3	2119
Acsf3	-1821
Hacd4	-3874
Elovl7	-8098
Hacd1	-8737

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acsl4	7747
Acsbg1	7636
Hsd17b12	7631
Elovl1	7473
Tecr	7018
Hacd2	6515
Acsl6	6049
Hacd3	5881
Elovl4	5850
Acsl5	4917
Acsl3	4277
Elovl6	2861
Acsl1	2715
Elovl5	2632
Elovl2	2613
Slc27a3	2119
Acsf3	-1821
Hacd4	-3874
Elovl7	-8098
Hacd1	-8737

GLYCOGEN BREAKDOWN GLYCOGENOLYSIS

GLYCOGEN BREAKDOWN GLYCOGENOLYSIS
	389
set	GLYCOGEN BREAKDOWN GLYCOGENOLYSIS
setSize	14
pANOVA	0.0108
s.dist	0.394
p.adjustANOVA	0.0596

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gyg	7709
Gaa	7535
Pygb	7372
Pygm	6866
Pgm2	6644
Phkb	5292
Phka1	3669
Phkg1	1377
Phkg2	1354
Agl	1034
Calm1	451
Phka2	-1545
Pgm2l1	-2578
Pygl	-2603

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gyg	7709
Gaa	7535
Pygb	7372
Pygm	6866
Pgm2	6644
Phkb	5292
Phka1	3669
Phkg1	1377
Phkg2	1354
Agl	1034
Calm1	451
Phka2	-1545
Pgm2l1	-2578
Pygl	-2603

SUPPRESSION OF PHAGOSOMAL MATURATION

SUPPRESSION OF PHAGOSOMAL MATURATION
	1029
set	SUPPRESSION OF PHAGOSOMAL MATURATION
setSize	12
pANOVA	0.0183
s.dist	0.393
p.adjustANOVA	0.0839

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rab5a	7203
Atp6v1h	6959
Rab7	5493
Hgs	5340
Kpna1	5148
Ubc	4500
Coro1a	3187
Kpnb1	3095
Vps33b	2935
Ubb	1303
Rps27a	-478
Uba52	-8214

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rab5a	7203
Atp6v1h	6959
Rab7	5493
Hgs	5340
Kpna1	5148
Ubc	4500
Coro1a	3187
Kpnb1	3095
Vps33b	2935
Ubb	1303
Rps27a	-478
Uba52	-8214

CS DS DEGRADATION

CS DS DEGRADATION
	192
set	CS DS DEGRADATION
setSize	14
pANOVA	0.0124
s.dist	0.386
p.adjustANOVA	0.0653

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ids	7281
Arsb	6727
Vcan	6689
Bgn	6560
Hexa	5632
Cspg4	4947
Bcan	4794
Cspg5	4632
Hexb	4301
Hyal3	1783
Hyal1	-217
Dcn	-2326
Ncan	-3335
Idua	-5808

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ids	7281
Arsb	6727
Vcan	6689
Bgn	6560
Hexa	5632
Cspg4	4947
Bcan	4794
Cspg5	4632
Hexb	4301
Hyal3	1783
Hyal1	-217
Dcn	-2326
Ncan	-3335
Idua	-5808

IRE1ALPHA ACTIVATES CHAPERONES

IRE1ALPHA ACTIVATES CHAPERONES
	499
set	IRE1ALPHA ACTIVATES CHAPERONES
setSize	50
pANOVA	2.69e-06
s.dist	0.384
p.adjustANOVA	0.000113

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tpp1	8361
Pdia6	8350
Dnajc3	8341
Hspa5	8305
Xbp1	8257
Srprb	7690
Atp6v0d1	7589
Dnajb11	7552
Gfpt1	7055
Dnajb9	7051
Srpr	6286
Lmna	6276
Dctn1	6188
Preb	6171
Hyou1	6156
Kdelr3	6076
Ppp2r5b	5757
Yif1a	5615
Ssr1	5263
Cxxc1	5183

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tpp1	8361
Pdia6	8350
Dnajc3	8341
Hspa5	8305
Xbp1	8257
Srprb	7690
Atp6v0d1	7589
Dnajb11	7552
Gfpt1	7055
Dnajb9	7051
Srpr	6286
Lmna	6276
Dctn1	6188
Preb	6171
Hyou1	6156
Kdelr3	6076
Ppp2r5b	5757
Yif1a	5615
Ssr1	5263
Cxxc1	5183
Syvn1	5168
Gosr2	4982
Add1	4819
Gsk3a	4754
Serp1	4344
Fkbp14	3752
Klhdc3	3596
Sec31a	2662
Hdgf	2607
Extl2	1797
Zbtb17	1437
Shc1	1324
Tln1	568
Pla2g4b	350
Extl3	129
Ddx11	-7
Tspyl2	-19
Cul7	-176
Mydgf	-424
Sult1a1	-440
Ctdsp2	-499
Arfgap1	-632
Edem1	-1059
Ern1	-1073
Tatdn2	-2662
Wfs1	-2872
Extl1	-3822
Acadvl	-5474
Wipi1	-6579
Pdia5	-6746

KERATAN SULFATE DEGRADATION

KERATAN SULFATE DEGRADATION
	506
set	KERATAN SULFATE DEGRADATION
setSize	11
pANOVA	0.0284
s.dist	0.382
p.adjustANOVA	0.114

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prelp	8307
Hexa	5632
Acan	5261
Gns	4656
Hexb	4301
Fmod	4018
Lum	3386
Glb1	2200
Glb1l	552
Ogn	-1934
Galns	-4080

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prelp	8307
Hexa	5632
Acan	5261
Gns	4656
Hexb	4301
Fmod	4018
Lum	3386
Glb1	2200
Glb1l	552
Ogn	-1934
Galns	-4080

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS

ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
	15
set	ACTIVATION OF AMPK DOWNSTREAM OF NMDARS
setSize	20
pANOVA	0.00336
s.dist	0.379
p.adjustANOVA	0.0262

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Prkab1	6043
Tubb3	5842
Prkag2	5796
Tuba1c	4485
Tubb6	1806
Prkag1	1594
Prkaa1	1545
Prkaa2	1347
Calm1	451
Mapt	-5193
Tuba8	-5577
Prkab2	-5817
Camkk2	-7039

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Prkab1	6043
Tubb3	5842
Prkag2	5796
Tuba1c	4485
Tubb6	1806
Prkag1	1594
Prkaa1	1545
Prkaa2	1347
Calm1	451
Mapt	-5193
Tuba8	-5577
Prkab2	-5817
Camkk2	-7039

RECYCLING PATHWAY OF L1

RECYCLING PATHWAY OF L1
	783
set	RECYCLING PATHWAY OF L1
setSize	40
pANOVA	3.41e-05
s.dist	0.379
p.adjustANOVA	0.00082

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rps6ka6	8267
Tubb2a	8130
Tuba1b	7873
Ap2m1	7792
Tubb4b	7622
Dnm2	7614
Ap2b1	7522
Tubb4a	7517
Tubb2b	7504
Rps6ka4	7347
Tuba4a	7208
Mapk1	7097
Tuba1a	7067
Ap2a2	6984
Ezr	6776
Ap2a1	6110
Tubb3	5842
Tuba1c	4485
Cltc	4483
Clta	3556

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rps6ka6	8267
Tubb2a	8130
Tuba1b	7873
Ap2m1	7792
Tubb4b	7622
Dnm2	7614
Ap2b1	7522
Tubb4a	7517
Tubb2b	7504
Rps6ka4	7347
Tuba4a	7208
Mapk1	7097
Tuba1a	7067
Ap2a2	6984
Ezr	6776
Ap2a1	6110
Tubb3	5842
Tuba1c	4485
Cltc	4483
Clta	3556
L1cam	3330
Sh3gl2	2855
Src	2551
Dnm3	2297
Rps6ka5	2127
Actg1	1983
Tubb6	1806
Numb	1403
Dnm1	814
Msn	773
Shtn1	78
Rps6ka2	-976
Rps6ka3	-1313
Rdx	-1895
Ap2s1	-3475
Rps6ka1	-4789
Tuba8	-5577
Dpysl2	-5750
Actb	-8390
Kif4	-8456

POST CHAPERONIN TUBULIN FOLDING PATHWAY

POST CHAPERONIN TUBULIN FOLDING PATHWAY
	725
set	POST CHAPERONIN TUBULIN FOLDING PATHWAY
setSize	17
pANOVA	0.00701
s.dist	0.378
p.adjustANOVA	0.0449

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Tbcd	7046
Tubb3	5842
Tuba1c	4485
Tubb6	1806
Arl2	-1610
Tbcb	-1675
Tbcc	-2972
Tbca	-5113
Tuba8	-5577
Tbce	-5838

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tubb2a	8130
Tuba1b	7873
Tubb4b	7622
Tubb4a	7517
Tubb2b	7504
Tuba4a	7208
Tuba1a	7067
Tbcd	7046
Tubb3	5842
Tuba1c	4485
Tubb6	1806
Arl2	-1610
Tbcb	-1675
Tbcc	-2972
Tbca	-5113
Tuba8	-5577
Tbce	-5838

COPI MEDIATED ANTEROGRADE TRANSPORT

COPI MEDIATED ANTEROGRADE TRANSPORT
	183
set	COPI MEDIATED ANTEROGRADE TRANSPORT
setSize	91
pANOVA	5.78e-10
s.dist	0.376
p.adjustANOVA	5.23e-08

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tmed9	8187
Tubb2a	8130
Arf4	8012
Tmed2	7972
Tuba1b	7873
Cog4	7856
Capza2	7704
Tmed7	7627
Tubb4b	7622
Cog1	7546
Tubb4a	7517
Tubb2b	7504
Copb1	7477
Actr1a	7389
Capza1	7253
Tuba4a	7208
Dctn4	7177
Tuba1a	7067
Cog6	6960
Arf1	6877

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tmed9	8187
Tubb2a	8130
Arf4	8012
Tmed2	7972
Tuba1b	7873
Cog4	7856
Capza2	7704
Tmed7	7627
Tubb4b	7622
Cog1	7546
Tubb4a	7517
Tubb2b	7504
Copb1	7477
Actr1a	7389
Capza1	7253
Tuba4a	7208
Dctn4	7177
Tuba1a	7067
Cog6	6960
Arf1	6877
Kdelr1	6862
Uso1	6853
Dctn6	6465
Arcn1	6445
Cd55	6367
Rab1b	6316
Dctn1	6188
Rab1a	6145
Kdelr3	6076
Tmed10	6028
Napg	5982
Tubb3	5842
Dync1i1	5759
Arfgap3	5741
Napa	5703
Folr1	5697
Dctn5	5433
Arfgap2	5268
Capzb	5208
Gosr2	4982
Nsf	4518
Tmed3	4493
Tuba1c	4485
Tmem115	4275
Ykt6	4251
Copa	4198
Gorasp1	4112
Copb2	3644
Dynll1	3613
Copz1	3591
Gbf1	3363
Dctn2	3314
Cope	3293
Cog5	3262
Copg1	3114
Actr10	2962
Dync1li1	2623
Napb	2381
Tubb6	1806
Arf3	1385
Dync1h1	1341
Sptbn5	1069
Cog2	852
Copg2	838
Sptan1	630
Stx5a	589
Dctn3	329
Cog7	83
Bet1	-245
Gosr1	-355
Arfgap1	-632
Sptbn1	-845
Arf5	-1490
Cog8	-1844
Dynll2	-1891
Cog3	-2028
Sptbn2	-2336
Sptb	-2663
Golga2	-3175
Sptbn4	-3397
Copz2	-3435
Dync1li2	-3541
Dync1i2	-3902
Ank1	-5320
Cd59b	-5413
Tuba8	-5577
Kdelr2	-5779
Ank2	-6065
Bet1l	-7424
Golgb1	-7435
Ank3	-8754

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-55                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.3      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.1.3          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] prettyunits_1.1.1      colorspace_2.0-2       blob_1.2.2            
##  [22] rvest_1.0.2            haven_2.4.3            xfun_0.29             
##  [25] crayon_1.4.2           RCurl_1.98-1.6         jsonlite_1.7.3        
##  [28] genefilter_1.74.1      survival_3.2-13        glue_1.6.1            
##  [31] polyclip_1.10-0        gtable_0.3.0           zlibbioc_1.38.0       
##  [34] XVector_0.32.0         webshot_0.5.2          DelayedArray_0.18.0   
##  [37] scales_1.1.1           DBI_1.1.2              Rcpp_1.0.8            
##  [40] progress_1.2.2         viridisLite_0.4.0      xtable_1.8-4          
##  [43] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.2            
##  [46] RColorBrewer_1.1-2     ellipsis_0.3.2         farver_2.1.0          
##  [49] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.8          
##  [52] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.4        
##  [55] utf8_1.2.2             labeling_0.4.2         tidyselect_1.1.1      
##  [58] rlang_1.0.1            later_1.3.0            AnnotationDbi_1.54.1  
##  [61] munsell_0.5.0          cellranger_1.1.0       tools_4.1.3           
##  [64] cachem_1.0.6           cli_3.1.1              generics_0.1.2        
##  [67] RSQLite_2.2.9          broom_0.7.12           evaluate_0.14         
##  [70] fastmap_1.1.0          yaml_2.2.2             knitr_1.37            
##  [73] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [76] KEGGREST_1.32.0        mime_0.12              xml2_1.3.3            
##  [79] compiler_4.1.3         rstudioapi_0.13        png_0.1-7             
##  [82] reprex_2.0.1           geneplotter_1.70.0     bslib_0.3.1           
##  [85] stringi_1.7.6          highr_0.9              desc_1.4.0            
##  [88] lattice_0.20-45        Matrix_1.4-0           vctrs_0.3.8           
##  [91] pillar_1.7.0           lifecycle_1.0.1        jquerylib_0.1.4       
##  [94] data.table_1.14.2      bitops_1.0-7           httpuv_1.6.5          
##  [97] R6_2.5.1               promises_1.2.0.1       KernSmooth_2.23-20    
## [100] gridExtra_2.3          assertthat_0.2.1       rprojroot_2.0.2       
## [103] withr_2.4.3            GenomeInfoDbData_1.2.6 hms_1.1.1             
## [106] grid_4.1.3             rmarkdown_2.11         shiny_1.7.1           
## [109] lubridate_1.8.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports