Mitch Report

date generated: 2022-03-15

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                         x
## 0610009B22Rik  0.45655760
## 0610009E02Rik -0.40699076
## 0610009L18Rik -0.18691102
## 0610010K14Rik -0.37114848
## 0610012G03Rik -0.34216334
## 0610030E20Rik  0.08425395

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	1604
num_genes_in_profile	17643
duplicated_genes_present	0
num_profile_genes_in_sets	8424
num_profile_genes_not_in_sets	9219

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	1604
num_genesets_excluded	426
num_genesets_included	1178

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
CITRIC ACID CYCLE TCA CYCLE	22	3.44e-05	0.510	9.41e-04
OLFACTORY SIGNALING PATHWAY	37	1.51e-07	-0.499	1.11e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	4.20e-03	0.498	3.30e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	3.04e-03	0.494	2.58e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	3.62e-03	0.485	2.96e-02
CALNEXIN CALRETICULIN CYCLE	26	2.35e-05	0.479	7.68e-04
ER QUALITY CONTROL COMPARTMENT ERQC	21	1.58e-04	0.476	2.98e-03
RHOBTB3 ATPASE CYCLE	10	9.36e-03	0.475	5.82e-02
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.92e-04	0.470	3.37e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	1.14e-03	0.470	1.27e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	3.98e-03	0.461	3.17e-02
ASPARTATE AND ASPARAGINE METABOLISM	10	1.25e-02	0.456	7.13e-02
MET ACTIVATES RAP1 AND RAC1	10	1.33e-02	0.452	7.32e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.75e-04	0.452	3.21e-03
RETROGRADE NEUROTROPHIN SIGNALLING	14	4.82e-03	0.435	3.64e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	1.87e-02	0.429	8.96e-02
SCAVENGING OF HEME FROM PLASMA	11	1.44e-02	-0.426	7.61e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	9.82e-04	0.426	1.14e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	1.56e-05	0.422	5.81e-04
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	1.88e-04	0.415	3.35e-03
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.13e-04	0.408	4.60e-03
CARNITINE METABOLISM	14	8.34e-03	0.407	5.35e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	2.60e-02	0.407	1.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	2.60e-02	0.407	1.11e-01
PROLONGED ERK ACTIVATION EVENTS	14	9.38e-03	0.401	5.82e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	7.62e-03	0.398	5.04e-02
FERTILIZATION	13	1.30e-02	-0.398	7.27e-02
GLYCOSPHINGOLIPID METABOLISM	38	2.63e-05	0.394	7.96e-04
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	3.83e-03	0.394	3.07e-02
SPHINGOLIPID METABOLISM	80	1.27e-09	0.393	1.87e-07
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS	11	2.42e-02	-0.392	1.07e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	42	1.25e-05	0.390	5.22e-04
NUCLEOBASE BIOSYNTHESIS	15	1.00e-02	0.384	6.10e-02
COHESIN LOADING ONTO CHROMATIN	10	3.74e-02	0.380	1.43e-01
CTLA4 INHIBITORY SIGNALING	20	3.62e-03	0.376	2.96e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.98e-02	0.373	9.44e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	1.24e-02	0.373	7.10e-02
RHOV GTPASE CYCLE	33	2.41e-04	0.369	3.89e-03
PLATELET SENSITIZATION BY LDL	15	1.38e-02	0.367	7.45e-02
INSULIN PROCESSING	24	1.96e-03	0.365	1.88e-02
LDL CLEARANCE	16	1.15e-02	0.365	6.71e-02
FATTY ACYL COA BIOSYNTHESIS	32	4.06e-04	0.361	5.69e-03
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	4.93e-02	0.359	1.73e-01
RECEPTOR MEDIATED MITOPHAGY	11	4.06e-02	0.357	1.52e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	1.70e-02	0.356	8.53e-02
INTRA GOLGI TRAFFIC	43	6.28e-05	0.353	1.45e-03
RHOF GTPASE CYCLE	41	9.74e-05	0.352	2.05e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	14	2.38e-02	0.349	1.07e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	3.01e-02	0.347	1.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	2.94e-05	0.345	8.65e-04

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
CITRIC ACID CYCLE TCA CYCLE	22	3.44e-05	0.510000	9.41e-04
OLFACTORY SIGNALING PATHWAY	37	1.51e-07	-0.499000	1.11e-05
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	4.20e-03	0.498000	3.30e-02
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	3.04e-03	0.494000	2.58e-02
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	3.62e-03	0.485000	2.96e-02
CALNEXIN CALRETICULIN CYCLE	26	2.35e-05	0.479000	7.68e-04
ER QUALITY CONTROL COMPARTMENT ERQC	21	1.58e-04	0.476000	2.98e-03
RHOBTB3 ATPASE CYCLE	10	9.36e-03	0.475000	5.82e-02
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.92e-04	0.470000	3.37e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	1.14e-03	0.470000	1.27e-02
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	3.98e-03	0.461000	3.17e-02
ASPARTATE AND ASPARAGINE METABOLISM	10	1.25e-02	0.456000	7.13e-02
MET ACTIVATES RAP1 AND RAC1	10	1.33e-02	0.452000	7.32e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.75e-04	0.452000	3.21e-03
RETROGRADE NEUROTROPHIN SIGNALLING	14	4.82e-03	0.435000	3.64e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	1.87e-02	0.429000	8.96e-02
SCAVENGING OF HEME FROM PLASMA	11	1.44e-02	-0.426000	7.61e-02
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	9.82e-04	0.426000	1.14e-02
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	1.56e-05	0.422000	5.81e-04
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	27	1.88e-04	0.415000	3.35e-03
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.13e-04	0.408000	4.60e-03
CARNITINE METABOLISM	14	8.34e-03	0.407000	5.35e-02
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	2.60e-02	0.407000	1.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	2.60e-02	0.407000	1.11e-01
PROLONGED ERK ACTIVATION EVENTS	14	9.38e-03	0.401000	5.82e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	7.62e-03	0.398000	5.04e-02
FERTILIZATION	13	1.30e-02	-0.398000	7.27e-02
GLYCOSPHINGOLIPID METABOLISM	38	2.63e-05	0.394000	7.96e-04
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	3.83e-03	0.394000	3.07e-02
SPHINGOLIPID METABOLISM	80	1.27e-09	0.393000	1.87e-07
DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS	11	2.42e-02	-0.392000	1.07e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	42	1.25e-05	0.390000	5.22e-04
NUCLEOBASE BIOSYNTHESIS	15	1.00e-02	0.384000	6.10e-02
COHESIN LOADING ONTO CHROMATIN	10	3.74e-02	0.380000	1.43e-01
CTLA4 INHIBITORY SIGNALING	20	3.62e-03	0.376000	2.96e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	1.98e-02	0.373000	9.44e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	1.24e-02	0.373000	7.10e-02
RHOV GTPASE CYCLE	33	2.41e-04	0.369000	3.89e-03
PLATELET SENSITIZATION BY LDL	15	1.38e-02	0.367000	7.45e-02
INSULIN PROCESSING	24	1.96e-03	0.365000	1.88e-02
LDL CLEARANCE	16	1.15e-02	0.365000	6.71e-02
FATTY ACYL COA BIOSYNTHESIS	32	4.06e-04	0.361000	5.69e-03
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	4.93e-02	0.359000	1.73e-01
RECEPTOR MEDIATED MITOPHAGY	11	4.06e-02	0.357000	1.52e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	1.70e-02	0.356000	8.53e-02
INTRA GOLGI TRAFFIC	43	6.28e-05	0.353000	1.45e-03
RHOF GTPASE CYCLE	41	9.74e-05	0.352000	2.05e-03
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	14	2.38e-02	0.349000	1.07e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	3.01e-02	0.347000	1.22e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	2.94e-05	0.345000	8.65e-04
ACYL CHAIN REMODELLING OF PG	10	5.97e-02	0.344000	1.94e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	2.23e-05	0.343000	7.51e-04
RHOU GTPASE CYCLE	34	5.35e-04	0.343000	7.16e-03
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	6.55e-03	0.343000	4.52e-02
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	10	6.07e-02	-0.343000	1.94e-01
RAP1 SIGNALLING	15	2.28e-02	0.340000	1.04e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	4.23e-02	0.339000	1.56e-01
CA DEPENDENT EVENTS	36	4.51e-04	0.338000	6.25e-03
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	15	2.42e-02	0.336000	1.07e-01
G PROTEIN MEDIATED EVENTS	52	3.04e-05	0.334000	8.65e-04
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	1.48e-02	0.332000	7.70e-02
DNA METHYLATION	23	6.01e-03	-0.331000	4.26e-02
NCAM1 INTERACTIONS	42	2.20e-04	-0.330000	3.59e-03
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	2.79e-02	0.328000	1.17e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	2.88e-02	0.326000	1.19e-01
PEROXISOMAL LIPID METABOLISM	27	3.49e-03	0.325000	2.89e-02
GLUTAMATE AND GLUTAMINE METABOLISM	13	4.26e-02	0.325000	1.56e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	3.04e-02	0.323000	1.23e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	53	5.37e-05	-0.321000	1.35e-03
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	1.58e-02	0.320000	8.00e-02
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	5.68e-03	0.320000	4.08e-02
SIGNALING BY HIPPO	20	1.39e-02	0.318000	7.45e-02
ACTIVATION OF SMO	16	2.85e-02	0.316000	1.19e-01
HYALURONAN UPTAKE AND DEGRADATION	11	7.23e-02	0.313000	2.17e-01
E2F MEDIATED REGULATION OF DNA REPLICATION	19	1.83e-02	0.313000	8.84e-02
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	24	8.35e-03	-0.311000	5.35e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY	27	5.32e-03	0.310000	3.91e-02
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	2.11e-04	0.309000	3.50e-03
RAF ACTIVATION	34	1.85e-03	0.309000	1.82e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	1.05e-02	-0.308000	6.30e-02
BIOTIN TRANSPORT AND METABOLISM	11	7.69e-02	0.308000	2.22e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	34	1.91e-03	-0.308000	1.86e-02
IRE1ALPHA ACTIVATES CHAPERONES	50	2.10e-04	0.303000	3.50e-03
EPHRIN SIGNALING	19	2.26e-02	0.302000	1.03e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	95	4.02e-07	-0.301000	2.50e-05
ERKS ARE INACTIVATED	13	6.07e-02	0.300000	1.94e-01
CONDENSATION OF PROPHASE CHROMOSOMES	30	4.41e-03	-0.300000	3.42e-02
O LINKED GLYCOSYLATION OF MUCINS	41	9.25e-04	0.299000	1.09e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	5.37e-02	0.298000	1.82e-01
INOSITOL PHOSPHATE METABOLISM	46	5.03e-04	0.297000	6.81e-03
DEPOLYMERISATION OF THE NUCLEAR LAMINA	13	6.45e-02	0.296000	2.01e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	32	3.81e-03	0.296000	3.07e-02
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	7.73e-02	0.295000	2.23e-01
COLLAGEN CHAIN TRIMERIZATION	41	1.11e-03	-0.294000	1.26e-02
EUKARYOTIC TRANSLATION ELONGATION	87	2.12e-06	-0.294000	1.19e-04
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	2.05e-02	0.292000	9.76e-02
NEGATIVE REGULATION OF MET ACTIVITY	20	2.38e-02	0.292000	1.07e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	4.40e-02	-0.291000	1.60e-01
CD28 CO STIMULATION	31	5.19e-03	0.290000	3.84e-02
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	14	6.04e-02	0.290000	1.94e-01
DEFECTS IN COBALAMIN B12 METABOLISM	13	7.04e-02	0.290000	2.15e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	26	1.09e-02	0.289000	6.41e-02
BETA CATENIN PHOSPHORYLATION CASCADE	16	4.69e-02	0.287000	1.67e-01
DAG AND IP3 SIGNALING	40	1.71e-03	0.287000	1.75e-02
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	5.51e-02	-0.286000	1.85e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	1.05e-01	-0.283000	2.74e-01
RHOB GTPASE CYCLE	69	5.02e-05	0.282000	1.29e-03
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	1.23e-01	0.281000	3.05e-01
PI METABOLISM	79	1.58e-05	0.281000	5.81e-04
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	2.58e-02	0.281000	1.11e-01
GLYCOGEN METABOLISM	25	1.54e-02	0.280000	7.89e-02
SYNTHESIS OF PA	29	9.09e-03	0.280000	5.70e-02
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	1.35e-03	0.279000	1.43e-02
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	18	4.03e-02	0.279000	1.51e-01
COMPLEX I BIOGENESIS	56	3.11e-04	-0.279000	4.60e-03
PARASITE INFECTION	54	4.04e-04	0.278000	5.69e-03
REGULATION OF IFNG SIGNALING	13	8.40e-02	0.277000	2.35e-01
RHOG GTPASE CYCLE	74	3.86e-05	0.277000	1.01e-03
REGULATION OF TP53 EXPRESSION AND DEGRADATION	34	5.43e-03	0.276000	3.95e-02
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	14	7.46e-02	0.275000	2.19e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	26	1.52e-02	0.275000	7.83e-02
NUCLEAR IMPORT OF REV PROTEIN	32	7.24e-03	0.274000	4.90e-02
THE PHOTOTRANSDUCTION CASCADE	22	2.63e-02	-0.274000	1.12e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	3.01e-02	0.273000	1.22e-01
NUCLEAR ENVELOPE NE REASSEMBLY	64	1.59e-04	0.273000	2.98e-03
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	14	7.87e-02	0.271000	2.26e-01
SUPPRESSION OF PHAGOSOMAL MATURATION	12	1.04e-01	0.271000	2.74e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	2.59e-02	0.268000	1.11e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	8.33e-02	0.267000	2.34e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	6.22e-03	0.267000	4.34e-02
GLYCOGEN SYNTHESIS	14	8.54e-02	0.266000	2.38e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	15	7.51e-02	0.265000	2.19e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	1.20e-02	0.265000	6.90e-02
RHOJ GTPASE CYCLE	55	6.83e-04	0.265000	8.65e-03
SPRY REGULATION OF FGF SIGNALING	16	6.80e-02	0.264000	2.10e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	5.30e-02	0.263000	1.81e-01
NEPHRIN FAMILY INTERACTIONS	23	2.88e-02	0.263000	1.19e-01
CELLULAR HEXOSE TRANSPORT	12	1.14e-01	0.263000	2.91e-01
AMINE LIGAND BINDING RECEPTORS	29	1.46e-02	0.262000	7.64e-02
VLDLR INTERNALISATION AND DEGRADATION	12	1.17e-01	0.261000	2.96e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	8.05e-04	0.261000	9.68e-03
TRANS GOLGI NETWORK VESICLE BUDDING	70	1.59e-04	0.261000	2.98e-03
DCC MEDIATED ATTRACTIVE SIGNALING	14	9.12e-02	0.261000	2.47e-01
VXPX CARGO TARGETING TO CILIUM	19	4.93e-02	0.261000	1.73e-01
RNA POLYMERASE III CHAIN ELONGATION	18	5.60e-02	-0.260000	1.86e-01
LYSINE CATABOLISM	11	1.35e-01	0.260000	3.25e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	1.25e-02	0.259000	7.14e-02
ACTIVATION OF RAC1	13	1.07e-01	0.258000	2.77e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	14	9.44e-02	0.258000	2.53e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	7.36e-03	0.258000	4.95e-02
P75NTR REGULATES AXONOGENESIS	10	1.60e-01	0.257000	3.59e-01
DISEASES OF DNA REPAIR	11	1.40e-01	0.257000	3.33e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	10	1.60e-01	0.257000	3.59e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	1.60e-01	0.257000	3.59e-01
CD28 DEPENDENT VAV1 PATHWAY	11	1.41e-01	0.256000	3.33e-01
PRE NOTCH PROCESSING IN GOLGI	18	5.99e-02	0.256000	1.94e-01
ERK MAPK TARGETS	22	3.79e-02	0.256000	1.45e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	15	8.78e-02	-0.255000	2.43e-01
PRC2 METHYLATES HISTONES AND DNA	32	1.28e-02	-0.254000	7.26e-02
SCAVENGING BY CLASS A RECEPTORS	14	9.96e-02	-0.254000	2.65e-01
ACYL CHAIN REMODELLING OF PE	18	6.21e-02	0.254000	1.97e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.28e-01	0.254000	3.12e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	7.55e-03	0.254000	5.02e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	3.96e-02	0.253000	1.50e-01
PHOSPHOLIPID METABOLISM	187	2.54e-09	0.253000	3.00e-07
RESPONSE OF MTB TO PHAGOCYTOSIS	21	4.57e-02	0.252000	1.64e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	1.73e-03	0.251000	1.75e-02
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	5.21e-02	0.251000	1.80e-01
APOPTOSIS INDUCED DNA FRAGMENTATION	10	1.71e-01	-0.250000	3.73e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	1.51e-01	-0.250000	3.48e-01
DERMATAN SULFATE BIOSYNTHESIS	11	1.52e-01	0.249000	3.49e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	2.26e-02	0.249000	1.03e-01
MTOR SIGNALLING	40	6.56e-03	0.248000	4.52e-02
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	1.75e-01	0.248000	3.79e-01
SYNTHESIS OF PE	13	1.22e-01	0.247000	3.04e-01
DEADENYLATION OF MRNA	25	3.32e-02	0.246000	1.31e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	2.18e-02	0.246000	1.02e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	1.25e-01	-0.246000	3.07e-01
CHONDROITIN SULFATE BIOSYNTHESIS	18	7.15e-02	0.245000	2.17e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	1.26e-01	0.245000	3.09e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	84	1.13e-04	0.244000	2.26e-03
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	88	7.85e-05	0.244000	1.68e-03
GLUTATHIONE SYNTHESIS AND RECYCLING	11	1.62e-01	0.243000	3.60e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	1.45e-02	0.242000	7.62e-02
NONSENSE MEDIATED DECAY NMD	109	1.29e-05	-0.242000	5.22e-04
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	1.85e-01	-0.242000	3.92e-01
KILLING MECHANISMS	11	1.66e-01	-0.241000	3.66e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	5.56e-02	0.241000	1.86e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	2.72e-02	0.241000	1.14e-01
NRAGE SIGNALS DEATH THROUGH JNK	56	1.81e-03	0.241000	1.79e-02
TELOMERE C STRAND SYNTHESIS INITIATION	13	1.33e-01	0.241000	3.21e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	81	1.83e-04	0.241000	3.32e-03
TRIGLYCERIDE BIOSYNTHESIS	10	1.88e-01	0.240000	3.97e-01
RAC2 GTPASE CYCLE	88	9.92e-05	0.240000	2.05e-03
RND2 GTPASE CYCLE	39	9.68e-03	0.239000	5.91e-02
MITOTIC TELOPHASE CYTOKINESIS	13	1.35e-01	0.239000	3.25e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	27	3.17e-02	-0.239000	1.28e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	23	4.80e-02	0.238000	1.70e-01
SIGNALING BY WNT IN CANCER	31	2.20e-02	0.238000	1.02e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	9.09e-02	0.237000	2.47e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	24	4.51e-02	0.236000	1.62e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	91	1.03e-04	0.236000	2.09e-03
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	2.33e-02	0.235000	1.06e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	25	4.17e-02	-0.235000	1.55e-01
RHOC GTPASE CYCLE	74	4.73e-04	0.235000	6.48e-03
TBC RABGAPS	43	7.69e-03	0.235000	5.06e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	1.29e-01	0.235000	3.13e-01
UNWINDING OF DNA	12	1.61e-01	0.234000	3.60e-01
FORMATION OF THE CORNIFIED ENVELOPE	31	2.42e-02	-0.234000	1.07e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	109	2.63e-05	0.233000	7.96e-04
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	2.99e-02	0.233000	1.22e-01
PEROXISOMAL PROTEIN IMPORT	59	2.07e-03	0.232000	1.95e-02
CYTOSOLIC TRNA AMINOACYLATION	24	4.94e-02	0.232000	1.73e-01
RESOLUTION OF SISTER CHROMATID COHESION	102	5.49e-05	0.231000	1.35e-03
INHIBITION OF DNA RECOMBINATION AT TELOMERE	38	1.37e-02	-0.231000	7.45e-02
SUMOYLATION OF SUMOYLATION PROTEINS	33	2.21e-02	0.230000	1.02e-01
MEMBRANE TRAFFICKING	581	3.96e-21	0.230000	4.66e-18
TRNA AMINOACYLATION	42	1.02e-02	0.229000	6.13e-02
RESPIRATORY ELECTRON TRANSPORT	102	6.43e-05	-0.229000	1.46e-03
ASPARAGINE N LINKED GLYCOSYLATION	285	3.17e-11	0.229000	6.23e-09
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	2.11e-01	0.228000	4.31e-01
RHOQ GTPASE CYCLE	58	2.65e-03	0.228000	2.35e-02
PYRUVATE METABOLISM	27	4.03e-02	0.228000	1.51e-01
CLATHRIN MEDIATED ENDOCYTOSIS	133	6.12e-06	0.227000	3.00e-04
LYSOSOME VESICLE BIOGENESIS	33	2.40e-02	0.227000	1.07e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	13	1.57e-01	0.227000	3.56e-01
HEME BIOSYNTHESIS	13	1.57e-01	0.227000	3.56e-01
OPIOID SIGNALLING	87	2.60e-04	0.227000	4.04e-03
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	2.23e-02	0.226000	1.03e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	1.58e-02	0.226000	8.00e-02
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	1.18e-07	0.226000	9.96e-06
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	1.19e-01	0.225000	2.98e-01
G0 AND EARLY G1	25	5.11e-02	0.225000	1.77e-01
G1 S SPECIFIC TRANSCRIPTION	26	4.69e-02	0.225000	1.67e-01
REGULATION OF KIT SIGNALING	16	1.19e-01	0.225000	2.98e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	171	3.92e-07	0.225000	2.50e-05
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	85	3.38e-04	0.225000	4.92e-03
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	1.97e-01	0.225000	4.07e-01
RMTS METHYLATE HISTONE ARGININES	46	8.40e-03	-0.225000	5.35e-02
GLYCOGEN STORAGE DISEASES	12	1.78e-01	0.225000	3.83e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	8.24e-02	0.224000	2.32e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	2.21e-01	0.224000	4.41e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	1.01e-01	-0.223000	2.69e-01
MTORC1 MEDIATED SIGNALLING	24	5.92e-02	0.222000	1.93e-01
PECAM1 INTERACTIONS	12	1.82e-01	0.222000	3.88e-01
RAB REGULATION OF TRAFFICKING	119	3.08e-05	0.221000	8.65e-04
BLOOD GROUP SYSTEMS BIOSYNTHESIS	15	1.39e-01	0.221000	3.31e-01
GAP JUNCTION DEGRADATION	11	2.06e-01	0.220000	4.21e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	24	6.20e-02	0.220000	1.97e-01
RHOD GTPASE CYCLE	51	6.63e-03	0.220000	4.54e-02
NUCLEAR ENVELOPE BREAKDOWN	49	7.94e-03	0.219000	5.17e-02
SIGNALLING TO ERKS	34	2.70e-02	0.219000	1.14e-01
REGULATION OF SIGNALING BY CBL	22	7.58e-02	0.219000	2.20e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	43	1.32e-02	0.218000	7.32e-02
PIWI INTERACTING RNA PIRNA BIOGENESIS	19	9.97e-02	-0.218000	2.65e-01
TIGHT JUNCTION INTERACTIONS	16	1.31e-01	0.218000	3.18e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	1.92e-01	0.218000	4.01e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	1.45e-01	0.218000	3.39e-01
PLATELET CALCIUM HOMEOSTASIS	26	5.58e-02	0.217000	1.86e-01
FGFR2 LIGAND BINDING AND ACTIVATION	12	1.94e-01	-0.217000	4.03e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	142	8.59e-06	0.216000	3.75e-04
HIV ELONGATION ARREST AND RECOVERY	32	3.43e-02	-0.216000	1.34e-01
RHOA GTPASE CYCLE	143	8.44e-06	0.216000	3.75e-04
GLYCOSAMINOGLYCAN METABOLISM	113	7.73e-05	0.215000	1.68e-03
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	6.82e-02	0.215000	2.10e-01
FCGR3A MEDIATED IL10 SYNTHESIS	32	3.53e-02	0.215000	1.37e-01
METABOLISM OF COFACTORS	19	1.05e-01	-0.215000	2.74e-01
BILE ACID AND BILE SALT METABOLISM	26	5.82e-02	0.215000	1.91e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	13	1.80e-01	-0.215000	3.85e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	1.75e-02	0.214000	8.63e-02
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	6.91e-02	0.214000	2.12e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	75	1.34e-03	0.214000	1.43e-02
GABA RECEPTOR ACTIVATION	55	6.04e-03	0.214000	4.26e-02
SLC TRANSPORTER DISORDERS	76	1.27e-03	0.214000	1.40e-02
GOLGI TO ER RETROGRADE TRANSPORT	119	5.70e-05	0.214000	1.37e-03
RHOBTB1 GTPASE CYCLE	23	7.70e-02	0.213000	2.22e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	2.70e-02	0.213000	1.14e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	2.02e-01	0.213000	4.17e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	102	2.10e-04	0.212000	3.50e-03
KERATINIZATION	32	3.82e-02	-0.212000	1.46e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	21	9.31e-02	0.212000	2.50e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	2.25e-01	0.211000	4.48e-01
SARS COV 2 INFECTION	65	3.35e-03	0.210000	2.82e-02
HDACS DEACETYLATE HISTONES	49	1.09e-02	-0.210000	6.41e-02
DARPP 32 EVENTS	23	8.09e-02	0.210000	2.29e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	1.13e-01	0.210000	2.89e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	50	1.02e-02	-0.210000	6.13e-02
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	1.11e-02	0.210000	6.51e-02
PLASMA LIPOPROTEIN CLEARANCE	28	5.50e-02	0.210000	1.85e-01
BUDDING AND MATURATION OF HIV VIRION	27	5.97e-02	0.209000	1.94e-01
RND1 GTPASE CYCLE	38	2.56e-02	0.209000	1.11e-01
INTERLEUKIN 17 SIGNALING	68	2.90e-03	0.209000	2.48e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	2.31e-01	0.208000	4.53e-01
GPVI MEDIATED ACTIVATION CASCADE	31	4.48e-02	0.208000	1.62e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	182	1.33e-06	0.208000	7.81e-05
BASE EXCISION REPAIR AP SITE FORMATION	32	4.22e-02	-0.207000	1.56e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	2.15e-01	0.207000	4.34e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	1.02e-01	0.206000	2.69e-01
SIGNALING BY BMP	25	7.48e-02	0.206000	2.19e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	1.03e-01	0.206000	2.71e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	2.61e-04	-0.205000	4.04e-03
TRANSMISSION ACROSS CHEMICAL SYNAPSES	244	3.73e-08	0.205000	3.66e-06
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	1.57e-01	-0.204000	3.56e-01
FATTY ACID METABOLISM	147	2.16e-05	0.203000	7.50e-04
VEGFR2 MEDIATED CELL PROLIFERATION	19	1.26e-01	0.203000	3.09e-01
INTEGRIN SIGNALING	24	8.56e-02	0.203000	2.38e-01
SARS COV 1 INFECTION	48	1.55e-02	0.202000	7.92e-02
VESICLE MEDIATED TRANSPORT	613	1.95e-17	0.201000	7.67e-15
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	1.63e-01	0.201000	3.62e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	1.65e-01	0.201000	3.64e-01
KERATAN SULFATE BIOSYNTHESIS	24	8.89e-02	0.201000	2.45e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	5.81e-02	0.200000	1.91e-01
METABOLISM OF CARBOHYDRATES	260	3.05e-08	0.200000	3.27e-06
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	1.17e-04	-0.200000	2.30e-03
EPHB MEDIATED FORWARD SIGNALING	42	2.53e-02	0.200000	1.10e-01
PENTOSE PHOSPHATE PATHWAY	13	2.13e-01	0.199000	4.33e-01
SIGNALING BY NTRK2 TRKB	24	9.09e-02	0.199000	2.47e-01
AUTOPHAGY	138	5.92e-05	0.198000	1.39e-03
MISMATCH REPAIR	15	1.84e-01	0.198000	3.91e-01
MITOTIC SPINDLE CHECKPOINT	97	7.52e-04	0.198000	9.23e-03
METABOLISM OF LIPIDS	618	5.42e-17	0.198000	1.60e-14
PURINE SALVAGE	12	2.36e-01	0.198000	4.56e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	33	4.98e-02	0.197000	1.74e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	2.02e-01	0.197000	4.17e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	49	1.72e-02	-0.197000	8.56e-02
KERATAN SULFATE KERATIN METABOLISM	30	6.28e-02	0.196000	1.97e-01
COPII MEDIATED VESICLE TRANSPORT	66	5.84e-03	0.196000	4.17e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	17	1.62e-01	0.196000	3.60e-01
VITAMIN B5 PANTOTHENATE METABOLISM	15	1.90e-01	0.196000	3.99e-01
NEUROTRANSMITTER RELEASE CYCLE	49	1.79e-02	0.196000	8.75e-02
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	35	4.54e-02	-0.196000	1.63e-01
LGI ADAM INTERACTIONS	14	2.05e-01	-0.195000	4.21e-01
NETRIN 1 SIGNALING	50	1.71e-02	0.195000	8.53e-02
INTERLEUKIN 6 SIGNALING	10	2.87e-01	0.195000	5.21e-01
GABA B RECEPTOR ACTIVATION	40	3.35e-02	0.194000	1.32e-01
FCERI MEDIATED MAPK ACTIVATION	28	7.56e-02	0.194000	2.20e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	2.66e-01	0.194000	4.97e-01
RECYCLING PATHWAY OF L1	40	3.44e-02	0.193000	1.34e-01
METABOLISM OF PORPHYRINS	19	1.45e-01	0.193000	3.39e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	7.20e-02	0.193000	2.17e-01
INTERLEUKIN 37 SIGNALING	18	1.57e-01	0.193000	3.56e-01
INTEGRATION OF ENERGY METABOLISM	100	8.88e-04	0.192000	1.06e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	2.14e-02	0.192000	1.01e-01
MEIOTIC RECOMBINATION	41	3.43e-02	-0.191000	1.34e-01
PEPTIDE HORMONE METABOLISM	62	9.44e-03	0.191000	5.82e-02
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	26	9.26e-02	0.191000	2.50e-01
RND3 GTPASE CYCLE	38	4.26e-02	0.190000	1.56e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	1.39e-02	0.190000	7.45e-02
FORMATION OF APOPTOSOME	10	2.99e-01	0.190000	5.34e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	91	1.78e-03	0.190000	1.78e-02
HS GAG BIOSYNTHESIS	30	7.27e-02	0.189000	2.17e-01
COSTIMULATION BY THE CD28 FAMILY	50	2.08e-02	0.189000	9.86e-02
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	3.04e-01	0.188000	5.39e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	3.04e-01	0.188000	5.39e-01
EUKARYOTIC TRANSLATION INITIATION	114	5.52e-04	-0.187000	7.30e-03
UNFOLDED PROTEIN RESPONSE UPR	86	2.80e-03	0.187000	2.41e-02
EFFECTS OF PIP2 HYDROLYSIS	27	9.59e-02	0.185000	2.57e-01
SIGNALING BY NTRKS	130	2.76e-04	0.185000	4.17e-03
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	97	1.73e-03	0.184000	1.75e-02
CIRCADIAN CLOCK	68	8.67e-03	0.184000	5.49e-02
RAC3 GTPASE CYCLE	91	2.42e-03	0.184000	2.23e-02
G ALPHA 12 13 SIGNALLING EVENTS	76	5.58e-03	0.184000	4.03e-02
PROCESSING AND ACTIVATION OF SUMO	10	3.16e-01	0.183000	5.52e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	2.21e-01	0.183000	4.41e-01
TRNA PROCESSING IN THE NUCLEUS	56	1.83e-02	0.182000	8.84e-02
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	2.71e-03	0.182000	2.36e-02
SIALIC ACID METABOLISM	32	7.49e-02	0.182000	2.19e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	12	2.75e-01	-0.182000	5.07e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	5.60e-02	0.182000	1.86e-01
CELLULAR RESPONSE TO HEAT STRESS	94	2.51e-03	0.180000	2.25e-02
MHC CLASS II ANTIGEN PRESENTATION	102	1.67e-03	0.180000	1.72e-02
SLC MEDIATED TRANSMEMBRANE TRANSPORT	193	1.63e-05	0.180000	5.81e-04
RHO GTPASES ACTIVATE KTN1	11	3.01e-01	0.180000	5.36e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	2.75e-03	0.180000	2.38e-02
HDR THROUGH MMEJ ALT NHEJ	10	3.25e-01	0.180000	5.64e-01
SYNTHESIS OF PC	26	1.14e-01	0.179000	2.91e-01
RHO GTPASES ACTIVATE FORMINS	119	7.50e-04	0.179000	9.23e-03
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	3.28e-01	0.179000	5.67e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	9.06e-02	0.179000	2.47e-01
SIGNALING BY RETINOIC ACID	33	7.64e-02	0.178000	2.22e-01
RAC1 GTPASE CYCLE	180	3.81e-05	0.178000	1.01e-03
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	3.30e-01	0.178000	5.68e-01
BASIGIN INTERACTIONS	22	1.48e-01	0.178000	3.42e-01
SIGNALING BY ACTIVIN	12	2.86e-01	0.178000	5.20e-01
TNF SIGNALING	43	4.42e-02	0.177000	1.60e-01
INTEGRIN CELL SURFACE INTERACTIONS	75	7.94e-03	-0.177000	5.17e-02
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	35	7.00e-02	-0.177000	2.14e-01
DNA STRAND ELONGATION	32	8.34e-02	0.177000	2.34e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	2.70e-01	0.177000	5.02e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	1.53e-01	0.176000	3.50e-01
GP1B IX V ACTIVATION SIGNALLING	11	3.12e-01	-0.176000	5.49e-01
CS DS DEGRADATION	14	2.57e-01	0.175000	4.85e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	27	1.16e-01	-0.175000	2.95e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	1.47e-01	-0.175000	3.40e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	2.28e-01	0.174000	4.51e-01
GLUCONEOGENESIS	27	1.18e-01	0.174000	2.98e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	4.39e-02	0.174000	1.60e-01
SIGNALING BY HEDGEHOG	141	3.75e-04	0.174000	5.39e-03
SIGNALING BY VEGF	104	2.26e-03	0.173000	2.09e-02
RHO GTPASE CYCLE	425	9.79e-10	0.173000	1.65e-07
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	1.60e-01	0.173000	3.59e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	2.18e-01	-0.173000	4.38e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	47	4.09e-02	-0.172000	1.53e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	225	8.54e-06	0.172000	3.75e-04
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	1.80e-02	0.172000	8.78e-02
RAB GERANYLGERANYLATION	57	2.48e-02	0.172000	1.09e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	1.66e-02	-0.172000	8.35e-02
SIGNALING BY SCF KIT	41	5.73e-02	0.172000	1.89e-01
IRON UPTAKE AND TRANSPORT	52	3.24e-02	0.172000	1.29e-01
ERYTHROPOIETIN ACTIVATES RAS	13	2.85e-01	0.171000	5.19e-01
COLLAGEN DEGRADATION	52	3.26e-02	-0.171000	1.29e-01
SIGNALING BY MET	74	1.09e-02	0.171000	6.41e-02
TRIGLYCERIDE METABOLISM	24	1.46e-01	0.171000	3.40e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	93	4.72e-03	0.170000	3.59e-02
CELL CELL COMMUNICATION	106	2.66e-03	0.169000	2.35e-02
INTERLEUKIN 10 SIGNALING	20	1.91e-01	-0.169000	4.01e-01
RNA POLYMERASE I PROMOTER ESCAPE	50	3.91e-02	-0.169000	1.48e-01
G ALPHA Z SIGNALLING EVENTS	44	5.30e-02	0.169000	1.81e-01
GLUCOSE METABOLISM	81	8.84e-03	0.168000	5.57e-02
FGFR1 MUTANT RECEPTOR ACTIVATION	26	1.37e-01	0.168000	3.29e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	7.13e-03	0.168000	4.85e-02
P75 NTR RECEPTOR MEDIATED SIGNALLING	95	4.73e-03	0.168000	3.59e-02
SHC MEDIATED CASCADE FGFR4	13	2.96e-01	-0.167000	5.32e-01
CARGO CONCENTRATION IN THE ER	31	1.07e-01	0.167000	2.77e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	2.64e-01	0.167000	4.94e-01
AMINO ACIDS REGULATE MTORC1	51	3.96e-02	0.167000	1.50e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS	162	2.73e-04	-0.166000	4.17e-03
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	1.30e-01	-0.165000	3.16e-01
PROTEIN METHYLATION	17	2.40e-01	0.165000	4.61e-01
DEATH RECEPTOR SIGNALLING	134	1.01e-03	0.165000	1.16e-02
METABOLISM OF STEROIDS	116	2.23e-03	0.164000	2.08e-02
SIGNALING BY EGFR	47	5.28e-02	0.163000	1.81e-01
SIGNAL AMPLIFICATION	31	1.16e-01	0.163000	2.95e-01
SELENOAMINO ACID METABOLISM	108	3.48e-03	-0.163000	2.89e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	52	4.24e-02	-0.163000	1.56e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	30	1.24e-01	0.162000	3.05e-01
MUCOPOLYSACCHARIDOSES	11	3.53e-01	0.162000	5.89e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	65	2.44e-02	-0.162000	1.07e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	1.50e-02	0.161000	7.79e-02
SULFUR AMINO ACID METABOLISM	23	1.80e-01	0.161000	3.85e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	14	2.97e-01	0.161000	5.32e-01
HYALURONAN METABOLISM	15	2.80e-01	0.161000	5.13e-01
MITOCHONDRIAL TRANSLATION	93	7.48e-03	-0.161000	5.01e-02
MITOTIC METAPHASE AND ANAPHASE	207	7.19e-05	0.160000	1.60e-03
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	74	1.74e-02	0.160000	8.63e-02
SEMA3A PAK DEPENDENT AXON REPULSION	16	2.69e-01	0.160000	5.01e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	3.60e-01	-0.160000	5.96e-01
REGULATION OF TNFR1 SIGNALING	34	1.08e-01	0.159000	2.78e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	63	2.90e-02	-0.159000	1.19e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	2.71e-01	-0.159000	5.02e-01
CYCLIN D ASSOCIATED EVENTS IN G1	46	6.20e-02	0.159000	1.97e-01
SENSORY PERCEPTION	158	6.00e-04	-0.158000	7.77e-03
EGFR DOWNREGULATION	28	1.47e-01	0.158000	3.40e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	3.45e-01	0.158000	5.80e-01
RHOBTB2 GTPASE CYCLE	23	1.93e-01	0.157000	4.03e-01
CDC42 GTPASE CYCLE	155	7.64e-04	0.157000	9.28e-03
REGULATION OF INSULIN SECRETION	72	2.16e-02	0.157000	1.01e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	631	2.39e-11	0.156000	5.62e-09
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	1.46e-01	0.156000	3.39e-01
NEURONAL SYSTEM	371	2.57e-07	0.156000	1.78e-05
PROTEIN UBIQUITINATION	70	2.42e-02	0.156000	1.07e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	2.40e-01	0.156000	4.61e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	3.31e-01	-0.156000	5.68e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	3.71e-01	0.156000	6.08e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	2.54e-01	0.155000	4.79e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	33	1.23e-01	-0.155000	3.05e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1226	1.18e-19	0.155000	6.97e-17
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	2.33e-01	0.154000	4.54e-01
INSULIN RECEPTOR RECYCLING	20	2.35e-01	0.154000	4.55e-01
LONG TERM POTENTIATION	23	2.03e-01	0.153000	4.17e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	107	6.14e-03	0.153000	4.31e-02
PI 3K CASCADE FGFR3	13	3.39e-01	0.153000	5.75e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	5.68e-02	0.153000	1.88e-01
NUCLEOBASE CATABOLISM	31	1.42e-01	0.152000	3.35e-01
RHO GTPASES ACTIVATE PKNS	50	6.28e-02	-0.152000	1.97e-01
SIGNALING BY KIT IN DISEASE	20	2.40e-01	0.152000	4.61e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	146	1.60e-03	0.151000	1.68e-02
INTERLEUKIN RECEPTOR SHC SIGNALING	20	2.43e-01	0.151000	4.64e-01
SIGNAL TRANSDUCTION BY L1	21	2.33e-01	0.150000	4.54e-01
HOST INTERACTIONS OF HIV FACTORS	125	3.70e-03	0.150000	3.01e-02
PROTEIN LOCALIZATION	158	1.14e-03	0.150000	1.27e-02
MET PROMOTES CELL MOTILITY	39	1.05e-01	0.150000	2.74e-01
CD209 DC SIGN SIGNALING	18	2.71e-01	0.150000	5.02e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	8.76e-02	0.149000	2.43e-01
G ALPHA I SIGNALLING EVENTS	204	2.52e-04	0.149000	4.02e-03
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.67e-01	0.148000	3.67e-01
METABOLISM OF NUCLEOTIDES	92	1.43e-02	0.148000	7.59e-02
TRANSCRIPTIONAL REGULATION BY RUNX1	182	5.89e-04	-0.148000	7.71e-03
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	119	5.38e-03	0.148000	3.94e-02
MYOGENESIS	25	2.01e-01	0.148000	4.16e-01
SEROTONIN RECEPTORS	10	4.19e-01	0.148000	6.48e-01
REGULATION OF BACH1 ACTIVITY	11	3.97e-01	0.148000	6.30e-01
SIGNALING BY FGFR3	35	1.32e-01	0.147000	3.19e-01
PROLACTIN RECEPTOR SIGNALING	11	3.99e-01	0.147000	6.31e-01
SELECTIVE AUTOPHAGY	71	3.23e-02	0.147000	1.29e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	3.46e-01	0.146000	5.81e-01
SHC1 EVENTS IN EGFR SIGNALING	11	4.03e-01	-0.145000	6.36e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	1.91e-01	0.145000	4.01e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	3.83e-01	0.145000	6.18e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	1.08e-01	0.145000	2.78e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	29	1.76e-01	-0.145000	3.80e-01
ACYL CHAIN REMODELLING OF PC	18	2.87e-01	0.145000	5.21e-01
TRANSPORT OF SMALL MOLECULES	586	2.25e-09	0.145000	2.95e-07
NEGATIVE REGULATION OF MAPK PATHWAY	42	1.05e-01	0.144000	2.74e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	72	3.43e-02	0.144000	1.34e-01
PKMTS METHYLATE HISTONE LYSINES	51	7.49e-02	-0.144000	2.19e-01
RHOBTB GTPASE CYCLE	35	1.41e-01	0.144000	3.33e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	2.05e-01	0.144000	4.20e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	2.33e-01	0.144000	4.54e-01
PYRIMIDINE SALVAGE	10	4.31e-01	0.144000	6.56e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	11	4.13e-01	0.143000	6.42e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	21	2.58e-01	0.142000	4.85e-01
LAGGING STRAND SYNTHESIS	20	2.71e-01	0.142000	5.02e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	2.09e-01	0.142000	4.27e-01
RRNA PROCESSING	194	6.48e-04	-0.142000	8.30e-03
SIGNALING BY EGFR IN CANCER	22	2.49e-01	-0.142000	4.72e-01
SEPARATION OF SISTER CHROMATIDS	166	1.62e-03	0.142000	1.69e-02
SNRNP ASSEMBLY	51	8.08e-02	0.141000	2.29e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	4.39e-01	0.141000	6.58e-01
RNA POLYMERASE III TRANSCRIPTION	41	1.18e-01	-0.141000	2.98e-01
ONCOGENIC MAPK SIGNALING	77	3.24e-02	0.141000	1.29e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	2.14e-01	0.141000	4.33e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	74	3.66e-02	0.141000	1.41e-01
SIGNALING BY GPCR	486	1.28e-07	0.140000	1.01e-05
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	4.44e-01	0.140000	6.62e-01
NOD1 2 SIGNALING PATHWAY	35	1.52e-01	0.140000	3.49e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	1.42e-01	-0.140000	3.35e-01
MITOPHAGY	29	1.94e-01	0.139000	4.03e-01
SIGNALING BY FGFR2 IN DISEASE	37	1.43e-01	-0.139000	3.35e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	6.25e-02	0.139000	1.97e-01
PLASMA LIPOPROTEIN REMODELING	14	3.69e-01	0.139000	6.06e-01
TOLL LIKE RECEPTOR CASCADES	139	4.89e-03	0.138000	3.67e-02
CELLULAR RESPONSE TO STARVATION	146	4.06e-03	-0.138000	3.21e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	6.07e-02	0.138000	1.94e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	24	2.43e-01	0.138000	4.64e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	2.65e-01	0.137000	4.95e-01
NUCLEOTIDE SALVAGE	21	2.77e-01	0.137000	5.08e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	85	2.99e-02	0.136000	1.22e-01
SIGNALING BY FGFR1 IN DISEASE	33	1.77e-01	0.136000	3.81e-01
MITOTIC PROMETAPHASE	177	1.94e-03	0.135000	1.88e-02
INFLUENZA INFECTION	145	5.10e-03	-0.135000	3.80e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	19	3.10e-01	0.135000	5.46e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	59	7.45e-02	0.134000	2.19e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	27	2.29e-01	0.134000	4.51e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	4.04e-01	-0.134000	6.36e-01
INTERLEUKIN 6 FAMILY SIGNALING	20	3.01e-01	0.134000	5.36e-01
CELL JUNCTION ORGANIZATION	73	4.87e-02	0.133000	1.72e-01
METABOLISM OF VITAMINS AND COFACTORS	152	4.62e-03	0.133000	3.56e-02
NEDDYLATION	217	7.47e-04	0.133000	9.23e-03
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	40	1.46e-01	-0.133000	3.39e-01
EPH EPHRIN SIGNALING	92	2.76e-02	0.133000	1.16e-01
INTERLEUKIN 2 FAMILY SIGNALING	32	1.93e-01	0.133000	4.03e-01
ION TRANSPORT BY P TYPE ATPASES	50	1.05e-01	0.133000	2.74e-01
PEXOPHAGY	11	4.47e-01	0.132000	6.65e-01
ESTROGEN DEPENDENT GENE EXPRESSION	107	1.86e-02	-0.132000	8.95e-02
BASE EXCISION REPAIR	60	7.77e-02	-0.132000	2.23e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	2.29e-01	0.131000	4.51e-01
GLUCAGON TYPE LIGAND RECEPTORS	26	2.47e-01	-0.131000	4.69e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	2.31e-01	-0.131000	4.53e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	2.33e-01	-0.130000	4.54e-01
CROSSLINKING OF COLLAGEN FIBRILS	15	3.83e-01	-0.130000	6.18e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	4.78e-01	-0.129000	6.92e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	4.59e-01	0.129000	6.79e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	1.45e-01	0.129000	3.39e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	68	6.70e-02	0.128000	2.08e-01
BIOLOGICAL OXIDATIONS	126	1.30e-02	0.128000	7.27e-02
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	94	3.17e-02	0.128000	1.28e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	1.66e-01	0.128000	3.66e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	3.34e-01	-0.128000	5.72e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	14	4.07e-01	0.128000	6.37e-01
NEUTROPHIL DEGRANULATION	389	1.61e-05	0.128000	5.81e-04
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	3.26e-01	0.127000	5.64e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	3.96e-01	0.127000	6.29e-01
CGMP EFFECTS	15	3.96e-01	-0.127000	6.29e-01
SIGNALING BY PTK6	51	1.19e-01	0.126000	2.98e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	1.53e-01	-0.126000	3.50e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	68	7.28e-02	-0.126000	2.17e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	51	1.20e-01	0.126000	3.01e-01
GLYCOLYSIS	67	7.50e-02	0.126000	2.19e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	4.71e-01	0.126000	6.88e-01
PHASE II CONJUGATION OF COMPOUNDS	64	8.24e-02	0.126000	2.32e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	6.40e-02	0.125000	2.00e-01
HEMOSTASIS	479	2.84e-06	0.125000	1.52e-04
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	4.35e-01	-0.125000	6.58e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	4.54e-01	0.125000	6.74e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	1.67e-01	0.125000	3.67e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	4.39e-01	-0.124000	6.58e-01
CELL CELL JUNCTION ORGANIZATION	48	1.38e-01	0.124000	3.30e-01
ADHERENS JUNCTIONS INTERACTIONS	30	2.41e-01	0.124000	4.61e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	2.13e-01	0.124000	4.33e-01
S PHASE	155	8.05e-03	0.123000	5.21e-02
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	20	3.42e-01	-0.123000	5.77e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	2.17e-01	0.122000	4.38e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	69	8.00e-02	-0.122000	2.29e-01
REDUCTION OF CYTOSOLIC CA LEVELS	12	4.65e-01	0.122000	6.83e-01
TRIGLYCERIDE CATABOLISM	14	4.31e-01	0.122000	6.56e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	2.28e-01	0.121000	4.51e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	3.74e-01	0.121000	6.11e-01
REPRODUCTION	80	6.16e-02	-0.121000	1.97e-01
PI3K AKT SIGNALING IN CANCER	91	4.63e-02	0.121000	1.65e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	3.38e-01	0.121000	5.75e-01
PLASMA LIPOPROTEIN ASSEMBLY	12	4.69e-01	0.121000	6.87e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	5.46e-02	0.121000	1.84e-01
G ALPHA Q SIGNALLING EVENTS	155	9.67e-03	0.121000	5.91e-02
SUMOYLATION OF TRANSCRIPTION FACTORS	18	3.77e-01	-0.120000	6.11e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	4.73e-01	0.120000	6.90e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	143	1.38e-02	0.119000	7.45e-02
RRNA PROCESSING IN THE MITOCHONDRION	10	5.14e-01	0.119000	7.11e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	52	1.37e-01	-0.119000	3.29e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	3.23e-01	-0.119000	5.61e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	2.93e-01	0.119000	5.30e-01
HEDGEHOG ON STATE	82	6.41e-02	0.118000	2.00e-01
HIV INFECTION	221	2.47e-03	0.118000	2.24e-02
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	3.07e-01	0.118000	5.42e-01
ATTENUATION PHASE	23	3.29e-01	-0.118000	5.67e-01
CRISTAE FORMATION	31	2.58e-01	-0.117000	4.85e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	2.74e-01	0.117000	5.06e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	3.89e-01	0.117000	6.24e-01
MICRORNA MIRNA BIOGENESIS	24	3.21e-01	-0.117000	5.58e-01
PREGNENOLONE BIOSYNTHESIS	12	4.83e-01	-0.117000	6.95e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	13	4.65e-01	0.117000	6.83e-01
SIGNALLING TO RAS	20	3.66e-01	0.117000	6.02e-01
SHC MEDIATED CASCADE FGFR1	16	4.19e-01	-0.117000	6.48e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	4.06e-01	0.116000	6.37e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	3.05e-01	0.116000	5.39e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	5.05e-01	-0.116000	7.07e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	4.36e-01	0.116000	6.58e-01
REGULATION OF FZD BY UBIQUITINATION	19	3.82e-01	0.116000	6.18e-01
ECM PROTEOGLYCANS	68	9.97e-02	-0.116000	2.65e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	4.39e-01	0.115000	6.58e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	45	1.80e-01	0.115000	3.85e-01
INITIAL TRIGGERING OF COMPLEMENT	12	4.90e-01	0.115000	6.97e-01
TIE2 SIGNALING	17	4.12e-01	0.115000	6.42e-01
O LINKED GLYCOSYLATION	86	6.63e-02	0.115000	2.06e-01
ERBB2 ACTIVATES PTK6 SIGNALING	12	4.92e-01	0.114000	6.98e-01
ION HOMEOSTASIS	50	1.62e-01	0.114000	3.60e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	466	2.59e-05	0.114000	7.96e-04
INNATE IMMUNE SYSTEM	784	7.26e-08	0.114000	6.58e-06
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	5.16e-01	0.113000	7.12e-01
SODIUM CALCIUM EXCHANGERS	10	5.37e-01	0.113000	7.28e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	68	1.10e-01	0.112000	2.83e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	4.40e-01	-0.111000	6.58e-01
EARLY PHASE OF HIV LIFE CYCLE	13	4.87e-01	-0.111000	6.96e-01
COLLAGEN FORMATION	79	8.81e-02	-0.111000	2.43e-01
DISEASES OF PROGRAMMED CELL DEATH	57	1.47e-01	-0.111000	3.40e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	36	2.49e-01	0.111000	4.72e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	284	1.32e-03	0.111000	1.43e-02
EPH EPHRIN MEDIATED REPULSION OF CELLS	51	1.71e-01	0.111000	3.73e-01
TRANSLESION SYNTHESIS BY POLK	17	4.29e-01	-0.111000	6.56e-01
GLUTATHIONE CONJUGATION	30	2.94e-01	0.111000	5.30e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	5.44e-01	0.111000	7.30e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	17	4.30e-01	-0.110000	6.56e-01
RNA POLYMERASE I TRANSCRIPTION	70	1.10e-01	-0.110000	2.83e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	4.32e-01	0.110000	6.56e-01
SARS COV INFECTIONS	140	2.49e-02	0.110000	1.09e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS	12	5.10e-01	-0.110000	7.09e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	39	2.41e-01	0.108000	4.61e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	4.99e-01	-0.108000	7.03e-01
ADAPTIVE IMMUNE SYSTEM	610	5.51e-06	0.108000	2.82e-04
HIV TRANSCRIPTION ELONGATION	42	2.26e-01	-0.108000	4.48e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	64	1.38e-01	0.107000	3.29e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	4.72e-01	0.107000	6.89e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	5.40e-01	0.107000	7.29e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	3.30e-01	0.106000	5.68e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	11	5.42e-01	-0.106000	7.29e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	86	8.91e-02	-0.106000	2.45e-01
NUCLEAR SIGNALING BY ERBB4	31	3.07e-01	0.106000	5.42e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	4.78e-01	0.106000	6.92e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	4.93e-01	-0.106000	6.98e-01
RHO GTPASES ACTIVATE CIT	18	4.39e-01	-0.105000	6.58e-01
ERBB2 REGULATES CELL MOTILITY	14	4.95e-01	0.105000	7.01e-01
PHASE 0 RAPID DEPOLARISATION	28	3.39e-01	-0.104000	5.75e-01
NICOTINATE METABOLISM	24	3.76e-01	0.104000	6.11e-01
RHO GTPASE EFFECTORS	253	4.40e-03	0.104000	3.42e-02
RHO GTPASES ACTIVATE IQGAPS	24	3.78e-01	0.104000	6.12e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	95	8.02e-02	0.104000	2.29e-01
SIGNALING BY NTRK3 TRKC	17	4.60e-01	-0.103000	6.80e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	286	2.68e-03	0.103000	2.36e-02
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	19	4.37e-01	0.103000	6.58e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	37	2.79e-01	0.103000	5.11e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	5.22e-01	-0.103000	7.14e-01
FC EPSILON RECEPTOR FCERI SIGNALING	123	5.07e-02	0.102000	1.76e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	4.30e-01	0.102000	6.56e-01
HEDGEHOG LIGAND BIOGENESIS	61	1.70e-01	0.102000	3.71e-01
DISEASES OF METABOLISM	198	1.42e-02	0.101000	7.59e-02
M PHASE	343	1.33e-03	0.101000	1.43e-02
SMOOTH MUSCLE CONTRACTION	33	3.16e-01	-0.101000	5.52e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	106	7.29e-02	-0.101000	2.17e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	1.84e-01	0.101000	3.91e-01
L1CAM INTERACTIONS	108	7.08e-02	0.101000	2.16e-01
POLYMERASE SWITCHING	14	5.14e-01	0.101000	7.11e-01
HCMV INFECTION	106	7.35e-02	0.101000	2.19e-01
PLATELET AGGREGATION PLUG FORMATION	32	3.25e-01	0.101000	5.64e-01
SIGNALING BY ROBO RECEPTORS	207	1.30e-02	-0.100000	7.27e-02
G PROTEIN ACTIVATION	23	4.06e-01	-0.100000	6.37e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	369	9.89e-04	0.100000	1.14e-02
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	3.14e-01	0.099700	5.51e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING	10	5.86e-01	-0.099400	7.64e-01
MITOTIC PROPHASE	97	9.10e-02	0.099400	2.47e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	5.51e-01	-0.099300	7.35e-01
SIGNALING BY TGFB FAMILY MEMBERS	97	9.11e-02	0.099300	2.47e-01
CELL CYCLE MITOTIC	479	2.11e-04	0.099100	3.50e-03
CONSTITUTIVE SIGNALING BY EGFRVIII	15	5.09e-01	-0.098600	7.07e-01
SIGNALING BY LEPTIN	10	5.89e-01	0.098600	7.65e-01
P38MAPK EVENTS	13	5.39e-01	0.098400	7.28e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	2.16e-01	0.098300	4.35e-01
REPRESSION OF WNT TARGET GENES	14	5.25e-01	-0.098200	7.16e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	92	1.05e-01	0.097800	2.74e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	3.39e-01	-0.097800	5.75e-01
SIGNALING BY FLT3 FUSION PROTEINS	19	4.62e-01	-0.097400	6.81e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	4.63e-01	0.097200	6.81e-01
FGFR1 LIGAND BINDING AND ACTIVATION	10	5.95e-01	-0.097100	7.68e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	347	2.07e-03	0.096400	1.95e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH	62	1.91e-01	-0.096200	4.01e-01
REGULATION OF IFNA SIGNALING	12	5.65e-01	0.096000	7.49e-01
HEDGEHOG OFF STATE	106	8.80e-02	0.096000	2.43e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	36	3.21e-01	0.095700	5.58e-01
GROWTH HORMONE RECEPTOR SIGNALING	20	4.63e-01	0.094900	6.81e-01
NEUREXINS AND NEUROLIGINS	54	2.29e-01	0.094800	4.51e-01
RHO GTPASES ACTIVATE ROCKS	19	4.75e-01	-0.094700	6.90e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.72e-01	0.094300	7.53e-01
LATE ENDOSOMAL MICROAUTOPHAGY	31	3.68e-01	0.093400	6.06e-01
TRP CHANNELS	20	4.70e-01	0.093200	6.88e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	4.20e-01	-0.093100	6.49e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	3.58e-01	0.092500	5.94e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	4.75e-01	0.092400	6.90e-01
SIGNALING BY FGFR4	34	3.52e-01	0.092300	5.87e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	28	3.98e-01	0.092200	6.31e-01
ANCHORING FIBRIL FORMATION	14	5.50e-01	-0.092200	7.35e-01
METABOLISM OF FAT SOLUBLE VITAMINS	32	3.69e-01	0.091900	6.06e-01
LEISHMANIA INFECTION	198	2.67e-02	0.091400	1.14e-01
REGULATION OF TP53 ACTIVITY	152	5.24e-02	0.091200	1.81e-01
INWARDLY RECTIFYING K CHANNELS	32	3.73e-01	0.090900	6.11e-01
SIGNALING BY ERBB2	49	2.72e-01	0.090800	5.02e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	4.96e-01	-0.090200	7.01e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	17	5.21e-01	-0.089900	7.14e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	4.88e-01	-0.089600	6.96e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	2.19e-01	0.089500	4.39e-01
GPCR LIGAND BINDING	270	1.16e-02	0.089400	6.71e-02
RHOH GTPASE CYCLE	37	3.47e-01	0.089300	5.82e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	58	2.40e-01	0.089300	4.61e-01
SIGNALING BY INSULIN RECEPTOR	65	2.13e-01	0.089300	4.33e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	62	2.25e-01	0.089100	4.48e-01
LAMININ INTERACTIONS	29	4.07e-01	-0.089100	6.37e-01
SIGNALING BY FGFR4 IN DISEASE	11	6.10e-01	-0.088900	7.76e-01
PROCESSING OF SMDT1	16	5.39e-01	0.088800	7.28e-01
RORA ACTIVATES GENE EXPRESSION	18	5.14e-01	0.088800	7.11e-01
ION CHANNEL TRANSPORT	143	6.78e-02	0.088500	2.10e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	6.12e-01	-0.088300	7.76e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	5.96e-01	-0.088300	7.69e-01
DISEASES OF GLYCOSYLATION	124	9.01e-02	0.088200	2.47e-01
PLATELET HOMEOSTASIS	78	1.79e-01	0.088100	3.84e-01
HIV LIFE CYCLE	142	7.12e-02	0.087800	2.16e-01
TELOMERE MAINTENANCE	81	1.73e-01	-0.087700	3.75e-01
FLT3 SIGNALING	36	3.64e-01	0.087500	6.00e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	32	3.93e-01	-0.087200	6.29e-01
RUNX2 REGULATES BONE DEVELOPMENT	29	4.18e-01	0.087000	6.47e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	3.95e-01	0.086800	6.29e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	2.99e-01	0.086700	5.34e-01
SIGNALING BY NOTCH3	48	3.02e-01	0.086100	5.37e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	20	5.07e-01	0.085800	7.07e-01
KERATAN SULFATE DEGRADATION	11	6.24e-01	0.085500	7.85e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	4.98e-01	-0.085400	7.02e-01
ONCOGENE INDUCED SENESCENCE	32	4.07e-01	0.084700	6.37e-01
MAPK FAMILY SIGNALING CASCADES	290	1.33e-02	0.084600	7.32e-02
TRANSLESION SYNTHESIS BY POLH	19	5.25e-01	-0.084200	7.16e-01
ACYL CHAIN REMODELLING OF PS	14	5.87e-01	0.083800	7.64e-01
HCMV LATE EVENTS	68	2.32e-01	0.083800	4.54e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	23	4.88e-01	-0.083500	6.96e-01
OXIDATIVE STRESS INDUCED SENESCENCE	81	1.97e-01	-0.083000	4.07e-01
CHOLESTEROL BIOSYNTHESIS	24	4.84e-01	0.082500	6.95e-01
RUNX3 REGULATES NOTCH SIGNALING	13	6.07e-01	0.082400	7.74e-01
ABC TRANSPORTER DISORDERS	70	2.34e-01	0.082300	4.54e-01
PYROPTOSIS	21	5.15e-01	-0.082100	7.11e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	3.41e-01	0.082100	5.76e-01
VIRAL MESSENGER RNA SYNTHESIS	42	3.60e-01	0.081600	5.96e-01
FRS MEDIATED FGFR3 SIGNALING	15	5.87e-01	0.081100	7.64e-01
INTERLEUKIN 1 FAMILY SIGNALING	123	1.21e-01	0.081100	3.01e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	33	4.21e-01	-0.081000	6.49e-01
AMYLOID FIBER FORMATION	61	2.74e-01	-0.080900	5.06e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	5.75e-01	-0.080900	7.57e-01
NEGATIVE REGULATION OF FLT3	14	6.02e-01	0.080600	7.71e-01
INTERLEUKIN 1 SIGNALING	96	1.73e-01	0.080500	3.75e-01
SIGNALING BY FGFR1	44	3.55e-01	0.080500	5.91e-01
SIGNALING BY THE B CELL RECEPTOR BCR	103	1.58e-01	0.080500	3.57e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	2.88e-01	-0.080000	5.22e-01
AQUAPORIN MEDIATED TRANSPORT	41	3.75e-01	0.080000	6.11e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	29	4.57e-01	0.079900	6.77e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	4.49e-01	0.079800	6.68e-01
METABOLISM OF POLYAMINES	57	3.01e-01	0.079200	5.36e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	5.51e-01	0.079100	7.35e-01
VISUAL PHOTOTRANSDUCTION	61	2.90e-01	-0.078400	5.24e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	6.52e-01	0.078400	8.09e-01
UB SPECIFIC PROCESSING PROTEASES	167	8.09e-02	0.078400	2.29e-01
NICOTINAMIDE SALVAGING	15	6.00e-01	0.078200	7.71e-01
DNA REPLICATION PRE INITIATION	80	2.30e-01	0.077700	4.51e-01
INTERACTION BETWEEN L1 AND ANKYRINS	27	4.85e-01	-0.077700	6.95e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	5.38e-01	0.077700	7.28e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	2.19e-01	-0.077600	4.39e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	13	6.29e-01	-0.077500	7.90e-01
DNA DAMAGE RECOGNITION IN GG NER	38	4.09e-01	0.077400	6.38e-01
SIGNALING BY INTERLEUKINS	351	1.34e-02	0.077000	7.32e-02
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	2.39e-01	0.076600	4.61e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	5.01e-01	0.076300	7.04e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	39	4.14e-01	-0.075600	6.44e-01
CILIUM ASSEMBLY	192	7.18e-02	0.075400	2.17e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	2.50e-01	0.075400	4.73e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	5.82e-01	0.075000	7.63e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	6.83e-01	0.074700	8.30e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	3.49e-01	0.074400	5.83e-01
FGFR2 ALTERNATIVE SPLICING	25	5.21e-01	-0.074200	7.14e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	30	4.84e-01	0.073900	6.95e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	5.69e-01	0.073500	7.53e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	118	1.69e-01	0.073300	3.71e-01
SIGNALING BY ERBB4	57	3.41e-01	0.073000	5.76e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	111	1.85e-01	-0.072900	3.92e-01
CELL CYCLE	597	2.44e-03	0.072800	2.23e-02
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	6.14e-01	-0.072800	7.76e-01
DEUBIQUITINATION	241	5.32e-02	0.072400	1.81e-01
METAL ION SLC TRANSPORTERS	25	5.32e-01	0.072200	7.24e-01
SIGNALING BY NOTCH1	75	2.81e-01	0.072000	5.14e-01
TRANSLATION	286	3.68e-02	-0.071900	1.42e-01
REGULATED NECROSIS	46	4.00e-01	-0.071800	6.32e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	66	3.14e-01	0.071700	5.51e-01
REGULATED PROTEOLYSIS OF P75NTR	12	6.68e-01	0.071600	8.24e-01
CELL CYCLE CHECKPOINTS	245	5.46e-02	0.071400	1.84e-01
SYNAPTIC ADHESION LIKE MOLECULES	21	5.71e-01	0.071300	7.53e-01
SIGNALING BY FGFR2 IIIA TM	19	5.90e-01	-0.071300	7.65e-01
DNA REPLICATION	122	1.75e-01	0.071100	3.79e-01
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	6.12e-01	0.071100	7.76e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	5.56e-01	0.070900	7.40e-01
FRS MEDIATED FGFR2 SIGNALING	19	5.93e-01	-0.070800	7.67e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	5.84e-01	0.070800	7.64e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	4.22e-01	0.070700	6.50e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	7.01e-01	0.070200	8.45e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	12	6.75e-01	0.069900	8.26e-01
METABOLISM OF FOLATE AND PTERINES	15	6.43e-01	0.069100	8.03e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	5.07e-01	-0.068900	7.07e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	5.43e-01	0.068900	7.30e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	29	5.23e-01	-0.068600	7.14e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	24	5.63e-01	-0.068300	7.46e-01
REGULATION OF RAS BY GAPS	66	3.38e-01	0.068200	5.75e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	6.71e-01	0.068100	8.26e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	66	3.39e-01	-0.068100	5.75e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	6.72e-01	0.067900	8.26e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	46	4.28e-01	-0.067600	6.56e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	5.84e-01	0.067500	7.64e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION	34	4.97e-01	0.067400	7.01e-01
TRAFFICKING OF AMPA RECEPTORS	31	5.17e-01	0.067300	7.12e-01
MEIOSIS	67	3.44e-01	-0.066800	5.80e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	64	3.55e-01	-0.066800	5.91e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	6.77e-01	-0.066800	8.26e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	7.02e-01	0.066700	8.45e-01
INSULIN RECEPTOR SIGNALLING CASCADE	46	4.35e-01	0.066600	6.58e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	152	1.62e-01	-0.065700	3.60e-01
GENE SILENCING BY RNA	85	2.95e-01	-0.065700	5.31e-01
G2 M DNA DAMAGE CHECKPOINT	69	3.47e-01	-0.065500	5.82e-01
KINESINS	47	4.39e-01	0.065200	6.58e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	187	1.26e-01	0.064900	3.09e-01
DSCAM INTERACTIONS	11	7.10e-01	0.064800	8.50e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	6.99e-01	-0.064600	8.45e-01
REGULATION OF PTEN GENE TRANSCRIPTION	58	3.95e-01	0.064500	6.29e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	5.94e-01	0.064300	7.67e-01
CHROMOSOME MAINTENANCE	104	2.60e-01	-0.064000	4.87e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	5.89e-01	-0.063800	7.65e-01
INTERFERON ALPHA BETA SIGNALING	54	4.18e-01	-0.063800	6.47e-01
INTERLEUKIN 7 SIGNALING	19	6.31e-01	-0.063600	7.92e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	6.16e-01	0.063200	7.78e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	4.23e-01	0.063100	6.50e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	5.86e-01	-0.063000	7.64e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	6.44e-01	-0.062900	8.04e-01
PYRIMIDINE CATABOLISM	10	7.32e-01	-0.062600	8.71e-01
RESOLUTION OF D LOOP STRUCTURES	31	5.49e-01	-0.062200	7.35e-01
RET SIGNALING	38	5.08e-01	0.062100	7.07e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES	317	5.84e-02	0.061900	1.91e-01
PURINE CATABOLISM	16	6.71e-01	0.061400	8.26e-01
TRNA PROCESSING	105	2.78e-01	0.061300	5.10e-01
MEIOTIC SYNAPSIS	43	4.98e-01	-0.059700	7.02e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	549	1.76e-02	0.059400	8.63e-02
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	60	4.27e-01	0.059400	6.55e-01
MRNA SPLICING	188	1.62e-01	-0.059100	3.60e-01
STRIATED MUSCLE CONTRACTION	26	6.05e-01	-0.058600	7.73e-01
PI3K EVENTS IN ERBB2 SIGNALING	15	6.95e-01	0.058500	8.42e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	6.30e-01	0.058100	7.91e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	27	6.04e-01	0.057700	7.73e-01
VOLTAGE GATED POTASSIUM CHANNELS	38	5.39e-01	0.057600	7.28e-01
FCERI MEDIATED CA 2 MOBILIZATION	26	6.12e-01	0.057500	7.76e-01
C TYPE LECTIN RECEPTORS CLRS	112	2.95e-01	0.057400	5.31e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	4.47e-01	-0.057200	6.65e-01
CRMPS IN SEMA3A SIGNALING	16	6.92e-01	-0.057100	8.40e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	27	6.08e-01	0.057000	7.75e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	6.75e-01	0.057000	8.26e-01
RESOLUTION OF ABASIC SITES AP SITES	38	5.43e-01	-0.057000	7.30e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	7.57e-01	0.056500	8.85e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	5.76e-01	-0.056300	7.57e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	7.47e-01	0.056200	8.80e-01
HCMV EARLY EVENTS	83	3.77e-01	0.056200	6.11e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	74	4.08e-01	-0.055700	6.37e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	6.61e-01	0.055300	8.18e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	4.62e-01	-0.054500	6.81e-01
DISEASES OF MITOTIC CELL CYCLE	37	5.68e-01	0.054300	7.51e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	5.38e-01	0.054300	7.28e-01
G ALPHA S SIGNALLING EVENTS	107	3.33e-01	0.054200	5.71e-01
SIGNALING BY NOTCH2	33	5.91e-01	0.054000	7.65e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	6.05e-01	0.053700	7.73e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	284	1.23e-01	0.053300	3.04e-01
PROTEIN FOLDING	90	3.86e-01	0.052900	6.21e-01
GAP JUNCTION ASSEMBLY	21	6.75e-01	0.052800	8.26e-01
INFECTIOUS DISEASE	736	1.52e-02	0.052800	7.83e-02
INTRINSIC PATHWAY FOR APOPTOSIS	52	5.12e-01	0.052600	7.10e-01
TP53 REGULATES METABOLIC GENES	85	4.03e-01	-0.052500	6.36e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	4.89e-01	0.052100	6.96e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	5.89e-01	0.052000	7.65e-01
IRAK4 DEFICIENCY TLR2 4	14	7.37e-01	-0.051900	8.75e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	2.45e-01	-0.051400	4.67e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	33	6.11e-01	0.051200	7.76e-01
CARDIAC CONDUCTION	107	3.62e-01	0.051000	5.98e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	6.02e-01	-0.051000	7.71e-01
RAS PROCESSING	24	6.66e-01	0.050900	8.22e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	6.73e-01	0.050800	8.26e-01
MATURATION OF NUCLEOPROTEIN	10	7.81e-01	-0.050800	8.94e-01
TCR SIGNALING	101	3.84e-01	0.050100	6.19e-01
TNFR2 NON CANONICAL NF KB PATHWAY	82	4.35e-01	0.049900	6.58e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	84	4.36e-01	0.049200	6.58e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	5.22e-01	-0.049000	7.14e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	15	7.44e-01	-0.048800	8.80e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	7.53e-01	0.048600	8.83e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	6.76e-01	-0.048200	8.26e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	24	6.85e-01	0.047900	8.32e-01
OTHER SEMAPHORIN INTERACTIONS	19	7.18e-01	-0.047800	8.57e-01
HOMOLOGY DIRECTED REPAIR	111	3.87e-01	-0.047600	6.21e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	7.67e-01	0.047500	8.88e-01
PRE NOTCH EXPRESSION AND PROCESSING	67	5.02e-01	-0.047500	7.04e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	94	4.31e-01	0.047000	6.56e-01
EXTENSION OF TELOMERES	49	5.70e-01	0.046900	7.53e-01
APOPTOTIC EXECUTION PHASE	45	5.87e-01	0.046800	7.64e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	64	5.17e-01	0.046800	7.12e-01
GAB1 SIGNALOSOME	14	7.63e-01	0.046500	8.86e-01
INTERFERON GAMMA SIGNALING	76	4.84e-01	-0.046500	6.95e-01
STIMULI SENSING CHANNELS	76	4.85e-01	0.046400	6.95e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	7.57e-01	0.046100	8.85e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	5.41e-01	-0.046000	7.29e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	33	6.48e-01	0.045900	8.08e-01
FCERI MEDIATED NF KB ACTIVATION	76	4.91e-01	0.045800	6.97e-01
CYTOPROTECTION BY HMOX1	120	3.88e-01	-0.045600	6.23e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	24	6.99e-01	-0.045500	8.45e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	13	7.77e-01	0.045400	8.94e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	7.08e-01	0.045100	8.50e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	7.64e-01	-0.044800	8.86e-01
ENDOSOMAL VACUOLAR PATHWAY	10	8.06e-01	0.044800	9.14e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	13	7.83e-01	-0.044200	8.95e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	7.69e-01	-0.043800	8.89e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	6.73e-01	-0.043800	8.26e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	64	5.45e-01	-0.043800	7.30e-01
MAP2K AND MAPK ACTIVATION	36	6.50e-01	0.043700	8.09e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	24	7.12e-01	0.043500	8.52e-01
ZINC TRANSPORTERS	16	7.64e-01	0.043400	8.86e-01
PCP CE PATHWAY	89	4.80e-01	0.043400	6.93e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	37	6.49e-01	-0.043300	8.08e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	6.78e-01	0.043100	8.27e-01
UCH PROTEINASES	89	4.83e-01	-0.043000	6.95e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	7.61e-01	-0.042600	8.86e-01
COMPLEMENT CASCADE	26	7.08e-01	0.042400	8.50e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	8.10e-01	-0.041900	9.15e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	5.99e-01	-0.041800	7.71e-01
FRS MEDIATED FGFR4 SIGNALING	15	7.80e-01	-0.041700	8.94e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	7.81e-01	-0.041400	8.94e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	5.20e-01	0.041400	7.14e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	6.22e-01	0.041100	7.84e-01
POTASSIUM CHANNELS	90	5.03e-01	0.040900	7.05e-01
SIGNALING BY PDGFR IN DISEASE	20	7.52e-01	0.040800	8.83e-01
PROGRAMMED CELL DEATH	186	3.38e-01	0.040800	5.75e-01
IRS MEDIATED SIGNALLING	41	6.52e-01	0.040800	8.09e-01
HDMS DEMETHYLATE HISTONES	30	7.01e-01	-0.040500	8.45e-01
INTRAFLAGELLAR TRANSPORT	52	6.14e-01	0.040400	7.76e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	5.37e-01	0.040200	7.28e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	5.57e-01	0.040100	7.40e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	7.35e-01	0.039900	8.74e-01
SUMOYLATION	168	3.74e-01	0.039800	6.11e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	7.97e-01	0.039700	9.06e-01
CLEC7A DECTIN 1 SIGNALING	94	5.08e-01	0.039600	7.07e-01
DNA DOUBLE STRAND BREAK RESPONSE	55	6.14e-01	0.039400	7.76e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	108	4.86e-01	0.038800	6.96e-01
ASSEMBLY OF THE HIV VIRION	16	7.91e-01	0.038300	9.01e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	24	7.46e-01	-0.038300	8.80e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	57	6.18e-01	-0.038200	7.80e-01
METHYLATION	11	8.28e-01	0.037700	9.22e-01
INTERLEUKIN 20 FAMILY SIGNALING	14	8.07e-01	0.037700	9.14e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	8.39e-01	-0.037100	9.27e-01
METABOLISM OF STEROID HORMONES	21	7.70e-01	0.036900	8.89e-01
CHROMATIN MODIFYING ENZYMES	222	3.48e-01	-0.036600	5.83e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	8.21e-01	0.036300	9.19e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	5.62e-01	-0.035800	7.46e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	25	7.58e-01	-0.035600	8.85e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	5.78e-01	0.035600	7.59e-01
INTERFERON SIGNALING	164	4.35e-01	0.035300	6.58e-01
METABOLISM OF RNA	645	1.28e-01	-0.035200	3.12e-01
ELASTIC FIBRE FORMATION	38	7.08e-01	0.035100	8.50e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	8.29e-01	0.034500	9.23e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	8.20e-01	0.033900	9.19e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	7.42e-01	-0.033700	8.80e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	8.54e-01	-0.033600	9.35e-01
PI 3K CASCADE FGFR2	17	8.11e-01	-0.033500	9.15e-01
PTEN REGULATION	133	5.07e-01	0.033400	7.07e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	6.02e-01	0.032800	7.71e-01
DISEASES OF IMMUNE SYSTEM	26	7.73e-01	-0.032700	8.92e-01
HSF1 DEPENDENT TRANSACTIVATION	33	7.47e-01	0.032500	8.80e-01
APOPTOSIS	164	4.75e-01	0.032300	6.90e-01
G1 S DNA DAMAGE CHECKPOINTS	65	6.53e-01	-0.032300	8.09e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	23	7.91e-01	0.031900	9.01e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	8.43e-01	0.031700	9.29e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	29	7.68e-01	0.031600	8.89e-01
ENOS ACTIVATION	11	8.60e-01	0.030800	9.36e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	8.66e-01	0.030800	9.39e-01
MITOTIC G2 G2 M PHASES	184	4.76e-01	0.030500	6.90e-01
SIGNALING BY WNT	272	3.91e-01	0.030300	6.26e-01
INFLAMMASOMES	19	8.20e-01	0.030100	9.19e-01
HSF1 ACTIVATION	25	7.96e-01	-0.029800	9.06e-01
DUAL INCISION IN TC NER	65	6.79e-01	-0.029700	8.27e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	64	6.81e-01	0.029700	8.29e-01
POTENTIAL THERAPEUTICS FOR SARS	77	6.53e-01	0.029700	8.09e-01
SIGNALING BY NUCLEAR RECEPTORS	228	4.44e-01	0.029500	6.62e-01
PHOSPHORYLATION OF THE APC C	17	8.36e-01	0.029100	9.27e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	6.42e-01	0.029000	8.03e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	41	7.48e-01	-0.029000	8.80e-01
PI 3K CASCADE FGFR1	16	8.42e-01	0.028900	9.29e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	8.52e-01	-0.028800	9.35e-01
DEGRADATION OF GLI1 BY THE PROTEASOME	57	7.09e-01	0.028600	8.50e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	15	8.48e-01	0.028500	9.33e-01
MITOCHONDRIAL PROTEIN IMPORT	63	6.99e-01	0.028200	8.45e-01
CA2 PATHWAY	59	7.10e-01	-0.028000	8.50e-01
INTERLEUKIN 15 SIGNALING	12	8.69e-01	-0.027500	9.39e-01
PHASE 2 PLATEAU PHASE	10	8.81e-01	-0.027400	9.43e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	8.33e-01	0.027200	9.26e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	8.55e-01	-0.026400	9.35e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	8.69e-01	0.026400	9.39e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	8.70e-01	-0.026200	9.39e-01
MRNA SPLICING MINOR PATHWAY	52	7.44e-01	-0.026200	8.80e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	66	7.15e-01	-0.026000	8.55e-01
SHC MEDIATED CASCADE FGFR3	13	8.72e-01	-0.025800	9.39e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	14	8.68e-01	-0.025700	9.39e-01
P75NTR SIGNALS VIA NF KB	16	8.59e-01	-0.025600	9.36e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	7.65e-01	0.025500	8.87e-01
NGF STIMULATED TRANSCRIPTION	36	7.92e-01	0.025500	9.01e-01
SIGNALING BY ERBB2 IN CANCER	25	8.26e-01	0.025400	9.21e-01
G PROTEIN BETA GAMMA SIGNALLING	31	8.13e-01	0.024600	9.15e-01
IRAK1 RECRUITS IKK COMPLEX	14	8.74e-01	0.024400	9.39e-01
MET ACTIVATES PTK2 SIGNALING	29	8.21e-01	0.024300	9.19e-01
DEGRADATION OF AXIN	53	7.61e-01	0.024200	8.86e-01
MRNA CAPPING	29	8.24e-01	0.023900	9.21e-01
NONHOMOLOGOUS END JOINING NHEJ	46	7.81e-01	-0.023700	8.94e-01
RHO GTPASES ACTIVATE PAKS	21	8.51e-01	-0.023700	9.35e-01
DNA DOUBLE STRAND BREAK REPAIR	140	6.42e-01	-0.022800	8.03e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	5.51e-01	-0.022500	7.35e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	7.78e-01	0.021900	8.94e-01
AGGREPHAGY	34	8.26e-01	0.021900	9.21e-01
INTERLEUKIN 12 FAMILY SIGNALING	43	8.08e-01	0.021400	9.14e-01
ORC1 REMOVAL FROM CHROMATIN	67	7.62e-01	0.021400	8.86e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	78	7.44e-01	0.021400	8.80e-01
SENSORY PROCESSING OF SOUND	62	7.74e-01	-0.021100	8.92e-01
DEVELOPMENTAL BIOLOGY	831	3.20e-01	-0.020400	5.58e-01
TRANSCRIPTIONAL REGULATION BY MECP2	59	7.91e-01	-0.019900	9.01e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	20	8.78e-01	0.019900	9.42e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	8.14e-01	0.019800	9.16e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	8.26e-01	0.019800	9.21e-01
INTERLEUKIN 12 SIGNALING	37	8.36e-01	0.019600	9.27e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	8.80e-01	0.019500	9.43e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	8.36e-01	-0.019400	9.27e-01
DAP12 INTERACTIONS	30	8.55e-01	-0.019300	9.35e-01
REGULATION OF BETA CELL DEVELOPMENT	30	8.56e-01	-0.019100	9.36e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	7.49e-01	-0.018900	8.80e-01
ANTIGEN PROCESSING CROSS PRESENTATION	97	7.48e-01	-0.018900	8.80e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	20	8.86e-01	-0.018600	9.48e-01
GENERATION OF SECOND MESSENGER MOLECULES	19	8.89e-01	-0.018500	9.50e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	74	7.86e-01	0.018200	8.99e-01
THE NLRP3 INFLAMMASOME	15	9.04e-01	0.018000	9.61e-01
DEGRADATION OF DVL	55	8.20e-01	-0.017700	9.19e-01
SIGNALING BY CSF3 G CSF	29	8.70e-01	0.017500	9.39e-01
FRS MEDIATED FGFR1 SIGNALING	18	8.98e-01	-0.017500	9.56e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	108	7.54e-01	-0.017400	8.84e-01
FLT3 SIGNALING IN DISEASE	28	8.74e-01	0.017300	9.39e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT	11	9.22e-01	-0.017000	9.72e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	68	8.11e-01	-0.016800	9.15e-01
RA BIOSYNTHESIS PATHWAY	13	9.18e-01	-0.016600	9.69e-01
SIGNALING BY ERYTHROPOIETIN	24	8.88e-01	0.016600	9.49e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	70	8.13e-01	0.016400	9.15e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	9.04e-01	-0.016400	9.61e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	9.25e-01	0.016300	9.74e-01
EXTRACELLULAR MATRIX ORGANIZATION	251	6.63e-01	-0.016000	8.19e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	8.07e-01	0.016000	9.14e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	8.59e-01	-0.015800	9.36e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	8.46e-01	-0.015400	9.31e-01
HIV TRANSCRIPTION INITIATION	45	8.58e-01	0.015400	9.36e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	8.38e-01	0.015000	9.27e-01
TRANSCRIPTIONAL REGULATION BY TP53	343	6.40e-01	0.014700	8.02e-01
SEMAPHORIN INTERACTIONS	64	8.39e-01	-0.014700	9.27e-01
DAP12 SIGNALING	24	9.02e-01	-0.014500	9.60e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	46	8.66e-01	-0.014400	9.39e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	8.96e-01	0.014300	9.56e-01
G2 M CHECKPOINTS	136	7.75e-01	-0.014200	8.93e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	9.09e-01	-0.014100	9.63e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	9.21e-01	-0.013900	9.72e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	51	8.66e-01	-0.013600	9.39e-01
SIGNALING BY FGFR	75	8.43e-01	0.013200	9.29e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	9.39e-01	0.012700	9.76e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	9.11e-01	0.012600	9.64e-01
ENDOGENOUS STEROLS	20	9.24e-01	0.012400	9.73e-01
JOSEPHIN DOMAIN DUBS	11	9.46e-01	0.011800	9.76e-01
MAPK6 MAPK4 SIGNALING	83	8.53e-01	-0.011800	9.35e-01
PI 3K CASCADE FGFR4	13	9.42e-01	0.011600	9.76e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	9.48e-01	-0.011400	9.76e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	9.27e-01	0.011000	9.74e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	9.08e-01	-0.010900	9.63e-01
DNA REPAIR	295	7.56e-01	-0.010500	8.85e-01
N GLYCAN ANTENNAE ELONGATION	15	9.45e-01	0.010300	9.76e-01
HEME SIGNALING	46	9.06e-01	-0.010100	9.61e-01
SIGNALING BY NOTCH4	83	8.74e-01	0.010100	9.39e-01
G BETA GAMMA SIGNALLING THROUGH CDC42	19	9.40e-01	0.009930	9.76e-01
ESR MEDIATED SIGNALING	171	8.24e-01	-0.009870	9.21e-01
SIGNALING BY NODAL	15	9.50e-01	0.009360	9.77e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	9.44e-01	0.009260	9.76e-01
NERVOUS SYSTEM DEVELOPMENT	553	7.16e-01	-0.009080	8.55e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	9.43e-01	0.008980	9.76e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	9.42e-01	0.008840	9.76e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	9.35e-01	-0.008720	9.76e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	606	7.19e-01	-0.008580	8.57e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	9.48e-01	0.008570	9.76e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	9.61e-01	-0.008550	9.80e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	29	9.37e-01	-0.008520	9.76e-01
PERK REGULATES GENE EXPRESSION	28	9.39e-01	-0.008380	9.76e-01
FANCONI ANEMIA PATHWAY	36	9.33e-01	0.008140	9.76e-01
CELLULAR SENESCENCE	144	8.68e-01	0.008050	9.39e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	9.30e-01	0.007960	9.76e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	94	8.97e-01	0.007760	9.56e-01
METALLOPROTEASE DUBS	26	9.48e-01	-0.007340	9.76e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	179	8.67e-01	0.007280	9.39e-01
DNA DAMAGE BYPASS	47	9.31e-01	-0.007270	9.76e-01
STABILIZATION OF P53	54	9.27e-01	-0.007250	9.74e-01
POLO LIKE KINASE MEDIATED EVENTS	14	9.63e-01	-0.007170	9.80e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	9.47e-01	0.007010	9.76e-01
TELOMERE EXTENSION BY TELOMERASE	22	9.55e-01	-0.006880	9.79e-01
SIGNALING BY NOTCH	192	8.73e-01	0.006710	9.39e-01
SURFACTANT METABOLISM	16	9.63e-01	0.006700	9.80e-01
ANTIMICROBIAL PEPTIDES	16	9.64e-01	-0.006450	9.81e-01
MITOCHONDRIAL BIOGENESIS	92	9.16e-01	0.006360	9.69e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	26	9.56e-01	-0.006320	9.79e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	60	9.42e-01	-0.005470	9.76e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	9.61e-01	-0.005240	9.80e-01
FOXO MEDIATED TRANSCRIPTION	57	9.48e-01	-0.005000	9.76e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	23	9.67e-01	-0.004980	9.82e-01
SYNDECAN INTERACTIONS	27	9.66e-01	0.004800	9.81e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	9.44e-01	-0.004750	9.76e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	9.53e-01	-0.004660	9.78e-01
SIGNALING BY FGFR2	63	9.49e-01	0.004650	9.76e-01
CELLULAR RESPONSE TO HYPOXIA	72	9.48e-01	-0.004430	9.76e-01
DUAL INCISION IN GG NER	41	9.61e-01	-0.004380	9.80e-01
NOTCH HLH TRANSCRIPTION PATHWAY	28	9.68e-01	-0.004330	9.82e-01
NUCLEOTIDE EXCISION REPAIR	110	9.41e-01	0.004070	9.76e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	9.74e-01	0.003990	9.85e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	9.79e-01	0.003970	9.87e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	85	9.53e-01	-0.003680	9.78e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	9.79e-01	-0.003620	9.87e-01
OTHER INTERLEUKIN SIGNALING	20	9.78e-01	0.003500	9.87e-01
TRANSCRIPTION OF THE HIV GENOME	67	9.61e-01	0.003430	9.80e-01
CHAPERONE MEDIATED AUTOPHAGY	20	9.80e-01	-0.003300	9.87e-01
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	9.86e-01	-0.003100	9.92e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	59	9.69e-01	0.002950	9.82e-01
PEPTIDE LIGAND BINDING RECEPTORS	112	9.61e-01	0.002710	9.80e-01
SIGNALING BY FGFR IN DISEASE	57	9.79e-01	-0.002010	9.87e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	9.91e-01	0.001650	9.95e-01
HATS ACETYLATE HISTONES	96	9.83e-01	0.001290	9.89e-01
SIGNALING BY PDGF	56	9.87e-01	-0.001250	9.92e-01
RNA POLYMERASE II TRANSCRIPTION	1098	9.73e-01	0.000604	9.85e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	140	9.92e-01	0.000471	9.96e-01
AURKA ACTIVATION BY TPX2	71	9.95e-01	0.000398	9.98e-01
ARACHIDONIC ACID METABOLISM	39	9.97e-01	0.000323	9.99e-01
HS GAG DEGRADATION	20	9.99e-01	-0.000233	9.99e-01
MUSCLE CONTRACTION	160	9.98e-01	-0.000098	9.99e-01

Detailed Gene set reports

CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
	154
set	CITRIC ACID CYCLE TCA CYCLE
setSize	22
pANOVA	3.44e-05
s.dist	0.51
p.adjustANOVA	0.000941

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fh1	9133
Idh3a	8827
Dld	8678
Suclg2	8614
Aco2	8602
Idh2	8064
Sucla2	7808
Idh3b	7713
Sdha	6929
Dlst	6267
Me2	6249
Cs	5426
Sdhd	5004
Idh3g	5001
Ogdh	4675
Nnt	3267
Mdh2	2250
Sdhb	1649
Sdhc	1351
Suclg1	982

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fh1	9133
Idh3a	8827
Dld	8678
Suclg2	8614
Aco2	8602
Idh2	8064
Sucla2	7808
Idh3b	7713
Sdha	6929
Dlst	6267
Me2	6249
Cs	5426
Sdhd	5004
Idh3g	5001
Ogdh	4675
Nnt	3267
Mdh2	2250
Sdhb	1649
Sdhc	1351
Suclg1	982
Me3	-990
Fahd1	-4036

OLFACTORY SIGNALING PATHWAY

OLFACTORY SIGNALING PATHWAY
	663
set	OLFACTORY SIGNALING PATHWAY
setSize	37
pANOVA	1.51e-07
s.dist	-0.499
p.adjustANOVA	1.11e-05

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Olfr981	-8240
Olfr1310	-8239
Olfr354	-8223
Olfr1192-ps1	-8078
Olfr90	-7978
Olfr635	-7971
Olfr1309	-7846
Olfr986	-7571
Gng13	-7562
Olfr1385	-7541
Olfr804	-7478
Olfr161	-7379
Olfr365	-7362
Olfr558	-7277
Olfr796	-7245
Olfr63	-7101
Olfr1507	-6904
Olfr78	-6875
Olfr1564	-6546
Olfr2	-5832

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Olfr981	-8240
Olfr1310	-8239
Olfr354	-8223
Olfr1192-ps1	-8078
Olfr90	-7978
Olfr635	-7971
Olfr1309	-7846
Olfr986	-7571
Gng13	-7562
Olfr1385	-7541
Olfr804	-7478
Olfr161	-7379
Olfr365	-7362
Olfr558	-7277
Olfr796	-7245
Olfr63	-7101
Olfr1507	-6904
Olfr78	-6875
Olfr1564	-6546
Olfr2	-5832
Olfr735	-5804
Olfr31	-5445
Rtp4	-5038
Olfr147	-3047
Olfr95	-2964
Olfr552	-1382
Olfr137	-1240
Reep4	-272
Reep6	-269
Olfr287	473
Olfr648	1879
Reep2	3136
Gnal	4031
Gnb1	4895
Reep3	5314
Reep5	6599
Reep1	7064

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
	1046
set	SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE
setSize	11
pANOVA	0.0042
s.dist	0.498
p.adjustANOVA	0.033

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fig4	9255
Pik3c3	6958
Pik3c2a	6871
Pik3r4	6218
Mtmr2	6064
Vac14	5945
Mtm1	5796
Mtmr7	5163
Mtmr4	4824
Mtmr9	-1103
Pikfyve	-1363

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fig4	9255
Pik3c3	6958
Pik3c2a	6871
Pik3r4	6218
Mtmr2	6064
Vac14	5945
Mtm1	5796
Mtmr7	5163
Mtmr4	4824
Mtmr9	-1103
Pikfyve	-1363

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM

ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
	47
set	ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
setSize	12
pANOVA	0.00304
s.dist	0.494
p.adjustANOVA	0.0258

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hsd17b4	8978
Elovl2	8860
Acox1	8768
Fads2	8555
Acsl1	7586
Fads1	7236
Elovl1	6340
Elovl5	6153
Scp2	4295
Acaa1a	-518
Acot8	-2870
Abcd1	-4259

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hsd17b4	8978
Elovl2	8860
Acox1	8768
Fads2	8555
Acsl1	7586
Fads1	7236
Elovl1	6340
Elovl5	6153
Scp2	4295
Acaa1a	-518
Acot8	-2870
Abcd1	-4259

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS

PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
	757
set	PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS
setSize	12
pANOVA	0.00362
s.dist	0.485
p.adjustANOVA	0.0296

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Paics	9163
Atic	7987
Adsl	7826
Gart	7723
Adss	6791
Impdh2	6200
Ppat	5022
Impdh1	3875
Gmps	3087
Lhpp	2720
Adssl1	2686
Pfas	-4910

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Paics	9163
Atic	7987
Adsl	7826
Gart	7723
Adss	6791
Impdh2	6200
Ppat	5022
Impdh1	3875
Gmps	3087
Lhpp	2720
Adssl1	2686
Pfas	-4910

CALNEXIN CALRETICULIN CYCLE

CALNEXIN CALRETICULIN CYCLE
	110
set	CALNEXIN CALRETICULIN CYCLE
setSize	26
pANOVA	2.35e-05
s.dist	0.479
p.adjustANOVA	0.000768

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Edem2	9300
Derl2	9261
Ganab	9006
Man1b1	8695
Pdia3	8431
Syvn1	8025
Amfr	7876
Uggt1	7856
Os9	7744
Rnf139	7183
Marchf6	7065
Edem3	6523
Ubc	5932
Edem1	5389
Calr	5198
Sel1l	5080
Rnf103	5033
Trim13	4178
Uggt2	3860
Rnf185	2134

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Edem2	9300
Derl2	9261
Ganab	9006
Man1b1	8695
Pdia3	8431
Syvn1	8025
Amfr	7876
Uggt1	7856
Os9	7744
Rnf139	7183
Marchf6	7065
Edem3	6523
Ubc	5932
Edem1	5389
Calr	5198
Sel1l	5080
Rnf103	5033
Trim13	4178
Uggt2	3860
Rnf185	2134
Canx	1752
Rnf5	1025
Prkcsh	96
Rps27a	-2071
Ubb	-2115
Uba52	-7859

ER QUALITY CONTROL COMPARTMENT ERQC

ER QUALITY CONTROL COMPARTMENT ERQC
	293
set	ER QUALITY CONTROL COMPARTMENT ERQC
setSize	21
pANOVA	0.000158
s.dist	0.476
p.adjustANOVA	0.00298

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Edem2	9300
Derl2	9261
Man1b1	8695
Syvn1	8025
Amfr	7876
Uggt1	7856
Os9	7744
Rnf139	7183
Marchf6	7065
Edem3	6523
Ubc	5932
Edem1	5389
Sel1l	5080
Rnf103	5033
Trim13	4178
Uggt2	3860
Rnf185	2134
Rnf5	1025
Rps27a	-2071
Ubb	-2115

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Edem2	9300
Derl2	9261
Man1b1	8695
Syvn1	8025
Amfr	7876
Uggt1	7856
Os9	7744
Rnf139	7183
Marchf6	7065
Edem3	6523
Ubc	5932
Edem1	5389
Sel1l	5080
Rnf103	5033
Trim13	4178
Uggt2	3860
Rnf185	2134
Rnf5	1025
Rps27a	-2071
Ubb	-2115
Uba52	-7859

RHOBTB3 ATPASE CYCLE

RHOBTB3 ATPASE CYCLE
	860
set	RHOBTB3 ATPASE CYCLE
setSize	10
pANOVA	0.00936
s.dist	0.475
p.adjustANOVA	0.0582

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Htr7	9100
Cul3	8203
Lrrc41	7885
Plin3	6740
Rhobtb3	6730
Hgs	5861
Rab9b	4398
Vhl	2581
Rab9	-1262
Ccne1	-2675

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Htr7	9100
Cul3	8203
Lrrc41	7885
Plin3	6740
Rhobtb3	6730
Hgs	5861
Rab9b	4398
Vhl	2581
Rab9	-1262
Ccne1	-2675

BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM
	104
set	BRANCHED CHAIN AMINO ACID CATABOLISM
setSize	21
pANOVA	0.000192
s.dist	0.47
p.adjustANOVA	0.00337

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Aldh6a1	9266
Ivd	8736
Dld	8678
Echs1	8363
Acat1	8250
Hibadh	8043
Dbt	7239
Acad8	7102
Slc25a44	6765
Acadsb	6761
Bcat2	6689
Bckdhb	6648
Mccc2	5898
Mccc1	5344
Hsd17b10	3221
Bcat1	2399
Hibch	-65
Bckdk	-1049
Bckdha	-1160
Auh	-1850

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Aldh6a1	9266
Ivd	8736
Dld	8678
Echs1	8363
Acat1	8250
Hibadh	8043
Dbt	7239
Acad8	7102
Slc25a44	6765
Acadsb	6761
Bcat2	6689
Bckdhb	6648
Mccc2	5898
Mccc1	5344
Hsd17b10	3221
Bcat1	2399
Hibch	-65
Bckdk	-1049
Bckdha	-1160
Auh	-1850
Ppm1k	-6285

SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE

SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
	1044
set	SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE
setSize	16
pANOVA	0.00114
s.dist	0.47
p.adjustANOVA	0.0127

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fig4	9255
Mtmr10	8910
Inpp5f	7618
Pi4k2a	7273
Pik3c3	6958
Pik3c2a	6871
Pik3r4	6218
Mtmr2	6064
Vac14	5945
Mtm1	5796
Inpp4b	5661
Mtmr4	4824
Mtmr12	2421
Pikfyve	-1363
Pi4k2b	-2260
Inpp4a	-4795

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fig4	9255
Mtmr10	8910
Inpp5f	7618
Pi4k2a	7273
Pik3c3	6958
Pik3c2a	6871
Pik3r4	6218
Mtmr2	6064
Vac14	5945
Mtm1	5796
Inpp4b	5661
Mtmr4	4824
Mtmr12	2421
Pikfyve	-1363
Pi4k2b	-2260
Inpp4a	-4795

INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1

INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
	448
set	INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1
setSize	13
pANOVA	0.00398
s.dist	0.461
p.adjustANOVA	0.0317

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prim2	8549
E2f1	8530
Tfdp1	8407
Prim1	7456
Rb1	7232
Pola2	7148
Pola1	5712
Ppp2ca	5171
Ppp2r1a	4643
Ppp2r1b	3997
Tfdp2	950
Ppp2cb	-1872
Ppp2r3d	-5628

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prim2	8549
E2f1	8530
Tfdp1	8407
Prim1	7456
Rb1	7232
Pola2	7148
Pola1	5712
Ppp2ca	5171
Ppp2r1a	4643
Ppp2r1b	3997
Tfdp2	950
Ppp2cb	-1872
Ppp2r3d	-5628

ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
	74
set	ASPARTATE AND ASPARAGINE METABOLISM
setSize	10
pANOVA	0.0125
s.dist	0.456
p.adjustANOVA	0.0713

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Folh1	9329
Asns	7860
Slc25a12	7310
Aspa	6690
Got1	6414
Got2	5975
Slc25a13	2805
Aspg	1022
Nat8l	-149
Naalad2	-1305

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Folh1	9329
Asns	7860
Slc25a12	7310
Aspa	6690
Got1	6414
Got2	5975
Slc25a13	2805
Aspg	1022
Nat8l	-149
Naalad2	-1305

MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
	539
set	MET ACTIVATES RAP1 AND RAC1
setSize	10
pANOVA	0.0133
s.dist	0.452
p.adjustANOVA	0.0732

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rac1	8591
Rap1b	7791
Crkl	7397
Crk	6793
Gab1	6014
Rap1a	5148
Met	3935
Rapgef1	3784
Grb2	-1885
Dock7	-1969

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rac1	8591
Rap1b	7791
Crkl	7397
Crk	6793
Gab1	6014
Rap1a	5148
Met	3935
Rapgef1	3784
Grb2	-1885
Dock7	-1969

BBSOME MEDIATED CARGO TARGETING TO CILIUM

BBSOME MEDIATED CARGO TARGETING TO CILIUM
	92
set	BBSOME MEDIATED CARGO TARGETING TO CILIUM
setSize	23
pANOVA	0.000175
s.dist	0.452
p.adjustANOVA	0.00321

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Lztfl1	8991
Tcp1	8148
Mchr1	7425
Arl6	7411
Mkks	7250
Bbs1	7110
Rab3ip	7096
Cct3	6618
Bbs7	6425
Cct5	6045
Ttc8	5746
Bbs10	5621
Bbs4	5540
Cct4	5520
Smo	5122
Cct2	3787
Sstr3	3325
Cct8	3153
Bbs2	306
Bbs12	-115

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Lztfl1	8991
Tcp1	8148
Mchr1	7425
Arl6	7411
Mkks	7250
Bbs1	7110
Rab3ip	7096
Cct3	6618
Bbs7	6425
Cct5	6045
Ttc8	5746
Bbs10	5621
Bbs4	5540
Cct4	5520
Smo	5122
Cct2	3787
Sstr3	3325
Cct8	3153
Bbs2	306
Bbs12	-115
Bbs9	-196
Bbip1	-690
Bbs5	-4881

RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
	842
set	RETROGRADE NEUROTROPHIN SIGNALLING
setSize	14
pANOVA	0.00482
s.dist	0.435
p.adjustANOVA	0.0364

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dnm2	9347
Ap2b1	7444
Ap2a2	7134
Ntrk1	6899
Cltc	6291
Dnm3	6028
Ngf	5435
Dnm1	4326
Ap2m1	4122
Ap2a1	3883
Sh3gl2	3298
Dnal4	1863
Clta	-54
Ap2s1	-4313

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dnm2	9347
Ap2b1	7444
Ap2a2	7134
Ntrk1	6899
Cltc	6291
Dnm3	6028
Ngf	5435
Dnm1	4326
Ap2m1	4122
Ap2a1	3883
Sh3gl2	3298
Dnal4	1863
Clta	-54
Ap2s1	-4313

CAMK IV MEDIATED PHOSPHORYLATION OF CREB

CAMK IV MEDIATED PHOSPHORYLATION OF CREB
	111
set	CAMK IV MEDIATED PHOSPHORYLATION OF CREB
setSize	10
pANOVA	0.0187
s.dist	0.429
p.adjustANOVA	0.0896

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Kpna2	9344
Creb1	8392
Camk2a	7843
Camkk1	6095
Camk2g	5543
Camk4	5130
Camk2d	3322
Camk2b	943
Camkk2	43
Calm1	-3079

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Kpna2	9344
Creb1	8392
Camk2a	7843
Camkk1	6095
Camk2g	5543
Camk4	5130
Camk2d	3322
Camk2b	943
Camkk2	43
Calm1	-3079

SCAVENGING OF HEME FROM PLASMA

SCAVENGING OF HEME FROM PLASMA
	907
set	SCAVENGING OF HEME FROM PLASMA
setSize	11
pANOVA	0.0144
s.dist	-0.426
p.adjustANOVA	0.0761

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Apol7e	-6909
Hp	-6777
Apol9a	-6641
Hbb-bt	-5506
Hba-a1	-5351
Jchain	-5032
Hba-a2	-4252
Apoa1	-2839
Apol8	1404
Lrp1	2282
Cd163	4594

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Apol7e	-6909
Hp	-6777
Apol9a	-6641
Hbb-bt	-5506
Hba-a1	-5351
Jchain	-5032
Hba-a2	-4252
Apoa1	-2839
Apol8	1404
Lrp1	2282
Cd163	4594

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS

SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
	1051
set	SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
setSize	20
pANOVA	0.000982
s.dist	0.426
p.adjustANOVA	0.0114

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acsbg1	9232
Acsl3	8989
Elovl2	8860
Acsl6	8499
Hsd17b12	7925
Acsl1	7586
Acsl4	7378
Hacd2	7234
Hacd4	6744
Elovl4	6612
Elovl1	6340
Elovl5	6153
Acsf3	4043
Acsl5	3751
Elovl6	3694
Hacd3	1138
Slc27a3	-2394
Tecr	-4047
Hacd1	-5403
Elovl7	-5881

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acsbg1	9232
Acsl3	8989
Elovl2	8860
Acsl6	8499
Hsd17b12	7925
Acsl1	7586
Acsl4	7378
Hacd2	7234
Hacd4	6744
Elovl4	6612
Elovl1	6340
Elovl5	6153
Acsf3	4043
Acsl5	3751
Elovl6	3694
Hacd3	1138
Slc27a3	-2394
Tecr	-4047
Hacd1	-5403
Elovl7	-5881

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE

N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
	594
set	N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE
setSize	35
pANOVA	1.56e-05
s.dist	0.422
p.adjustANOVA	0.000581

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Edem2	9300
Derl2	9261
Ganab	9006
Man1b1	8695
Derl1	8460
Pdia3	8431
Mlec	8086
Syvn1	8025
Ngly1	8020
Amfr	7876
Uggt1	7856
Os9	7744
Rnf139	7183
Marchf6	7065
Edem3	6523
Ubc	5932
Edem1	5389
Calr	5198
Sel1l	5080
Rnf103	5033

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Edem2	9300
Derl2	9261
Ganab	9006
Man1b1	8695
Derl1	8460
Pdia3	8431
Mlec	8086
Syvn1	8025
Ngly1	8020
Amfr	7876
Uggt1	7856
Os9	7744
Rnf139	7183
Marchf6	7065
Edem3	6523
Ubc	5932
Edem1	5389
Calr	5198
Sel1l	5080
Rnf103	5033
Rad23b	4886
Vcp	4493
Trim13	4178
Uggt2	3860
Rnf185	2134
Canx	1752
Rnf5	1025
Engase	897
Prkcsh	96
Rps27a	-2071
Ubb	-2115
Ubxn1	-2534
Mogs	-2859
Psmc1	-4016
Uba52	-7859

THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS

THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
	1073
set	THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS
setSize	27
pANOVA	0.000188
s.dist	0.415
p.adjustANOVA	0.00335

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ap1m1	9091
Elmo1	8839
Pak2	8711
Fyn	8650
Rac1	8591
Ap1b1	7973
H2-Q2	7969
Atp6v1h	7606
Ap2b1	7444
Ap2a2	7134
Hck	6758
Dock2	6604
Ap1m2	5627
Arf1	4881
Pacs1	4524
Ap2m1	4122
Ap2a1	3883
Ap1g1	3869
Ap1s1	3748
Ap1s2	2197

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ap1m1	9091
Elmo1	8839
Pak2	8711
Fyn	8650
Rac1	8591
Ap1b1	7973
H2-Q2	7969
Atp6v1h	7606
Ap2b1	7444
Ap2a2	7134
Hck	6758
Dock2	6604
Ap1m2	5627
Arf1	4881
Pacs1	4524
Ap2m1	4122
Ap2a1	3883
Ap1g1	3869
Ap1s1	3748
Ap1s2	2197
Lck	1852
H2-Q7	40
B2m	-114
H2-D1	-2015
H2-Q10	-2381
Ap2s1	-4313
Ap1s3	-7097

POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION

POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
	728
set	POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION
setSize	26
pANOVA	0.000313
s.dist	0.408
p.adjustANOVA	0.0046

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nup54	8879
Ndc1	8176
Rcc1	7498
Nup160	7385
Tnpo1	7074
Nup107	6351
Nup205	6182
Pom121	5822
Nup133	5734
Nup37	5696
Sec13	5690
Kpnb1	5613
Seh1l	4719
Nup85	4516
Ahctf1	4490
Ube2i	4393
Nup188	3203
Sumo1	2910
Ran	2863
Rangap1	2273

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nup54	8879
Ndc1	8176
Rcc1	7498
Nup160	7385
Tnpo1	7074
Nup107	6351
Nup205	6182
Pom121	5822
Nup133	5734
Nup37	5696
Sec13	5690
Kpnb1	5613
Seh1l	4719
Nup85	4516
Ahctf1	4490
Ube2i	4393
Nup188	3203
Sumo1	2910
Ran	2863
Rangap1	2273
Nup98	2184
Nup35	1611
Nup43	1247
Nup93	-1282
Nup62	-1905
Nup155	-2921

CARNITINE METABOLISM

CARNITINE METABOLISM
	117
set	CARNITINE METABOLISM
setSize	14
pANOVA	0.00834
s.dist	0.407
p.adjustANOVA	0.0535

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cpt1a	8349
Prkag2	7700
Cpt2	7512
Rxra	7494
Prkaa2	7318
Cpt1b	6931
Mid1ip1	6514
Acacb	4802
Acaca	3651
Ppard	2869
Slc25a20	2357
Thrsp	18
Prkab2	-699
Slc22a5	-6559

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cpt1a	8349
Prkag2	7700
Cpt2	7512
Rxra	7494
Prkaa2	7318
Cpt1b	6931
Mid1ip1	6514
Acacb	4802
Acaca	3651
Ppard	2869
Slc25a20	2357
Thrsp	18
Prkab2	-699
Slc22a5	-6559

ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS

ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
	8
set	ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS
setSize	10
pANOVA	0.026
s.dist	0.407
p.adjustANOVA	0.111

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Chrna3	9155
Chrna4	7286
Chrna6	6848
Chrna5	6009
Chrnb4	5457
Chrnb2	4195
Chrnb3	2106
Chrna2	1054
Chrna7	1
Chrna1	-542

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Chrna3	9155
Chrna4	7286
Chrna6	6848
Chrna5	6009
Chrnb4	5457
Chrnb2	4195
Chrnb3	2106
Chrna2	1054
Chrna7	1
Chrna1	-542

HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS

HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
	422
set	HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS
setSize	10
pANOVA	0.026
s.dist	0.407
p.adjustANOVA	0.111

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Chrna3	9155
Chrna4	7286
Chrna6	6848
Chrna5	6009
Chrnb4	5457
Chrnb2	4195
Chrnb3	2106
Chrna2	1054
Chrna7	1
Chrna1	-542

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Chrna3	9155
Chrna4	7286
Chrna6	6848
Chrna5	6009
Chrnb4	5457
Chrnb2	4195
Chrnb3	2106
Chrna2	1054
Chrna7	1
Chrna1	-542

PROLONGED ERK ACTIVATION EVENTS

PROLONGED ERK ACTIVATION EVENTS
	747
set	PROLONGED ERK ACTIVATION EVENTS
setSize	14
pANOVA	0.00938
s.dist	0.401
p.adjustANOVA	0.0582

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mapk1	8052
Map2k1	7865
Crkl	7397
Ntrk1	6899
Crk	6793
Ngf	5435
Mapk3	5188
Rap1a	5148
Frs2	3800
Rapgef1	3784
Ywhab	3617
Braf	1445
Kidins220	-3045
Map2k2	-4884

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mapk1	8052
Map2k1	7865
Crkl	7397
Ntrk1	6899
Crk	6793
Ngf	5435
Mapk3	5188
Rap1a	5148
Frs2	3800
Rapgef1	3784
Ywhab	3617
Braf	1445
Kidins220	-3045
Map2k2	-4884

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
	1045
set	SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
setSize	15
pANOVA	0.00762
s.dist	0.398
p.adjustANOVA	0.0504

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fig4	9255
Sacm1l	7742
Pi4k2a	7273
Pik3c3	6958
Pik3c2a	6871
Pik3r4	6218
Ocrl	6104
Vac14	5945
Pi4kb	5175
Arf1	4881
Pi4ka	74
Inpp5e	44
Pikfyve	-1363
Arf3	-1726
Pi4k2b	-2260

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fig4	9255
Sacm1l	7742
Pi4k2a	7273
Pik3c3	6958
Pik3c2a	6871
Pik3r4	6218
Ocrl	6104
Vac14	5945
Pi4kb	5175
Arf1	4881
Pi4ka	74
Inpp5e	44
Pikfyve	-1363
Arf3	-1726
Pi4k2b	-2260

FERTILIZATION

FERTILIZATION
	321
set	FERTILIZATION
setSize	13
pANOVA	0.013
s.dist	-0.398
p.adjustANOVA	0.0727

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acr	-7105
Ovgp1	-6722
Catsperd	-6267
Adam21	-5799
Catsper3	-5156
Catsperg1	-4963
Hvcn1	-3776
B4galt1	-2665
Izumo4	-2140
Catsper2	-1857
Kcnu1	-1465
Cd9	3074
Catsperg2	6686

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acr	-7105
Ovgp1	-6722
Catsperd	-6267
Adam21	-5799
Catsper3	-5156
Catsperg1	-4963
Hvcn1	-3776
B4galt1	-2665
Izumo4	-2140
Catsper2	-1857
Kcnu1	-1465
Cd9	3074
Catsperg2	6686

GLYCOSPHINGOLIPID METABOLISM

GLYCOSPHINGOLIPID METABOLISM
	395
set	GLYCOSPHINGOLIPID METABOLISM
setSize	38
pANOVA	2.63e-05
s.dist	0.394
p.adjustANOVA	0.000796

Top enriched genes

Top 20 genes
GeneID	Gene Rank
B3galnt1	9230
Gla	9201
Arsa	8981
Neu3	8944
Galc	8882
Asah1	8647
Neu4	8522
Esyt1	8442
Arsb	8276
B4galnt1	7463
Gba2	7449
Ugt8a	6366
Psap	6328
Ugcg	6318
Gltp	6022
Neu1	5420
Cerk	5234
Neu2	5146
Cptp	5086
Gm2a	5036

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
B3galnt1	9230
Gla	9201
Arsa	8981
Neu3	8944
Galc	8882
Asah1	8647
Neu4	8522
Esyt1	8442
Arsb	8276
B4galnt1	7463
Gba2	7449
Ugt8a	6366
Psap	6328
Ugcg	6318
Gltp	6022
Neu1	5420
Cerk	5234
Neu2	5146
Cptp	5086
Gm2a	5036
Hexb	4729
Glb1l	4482
Gba	4021
Arsg	3793
Arsk	3006
Smpd1	2483
Smpd3	2172
Glb1	1254
Esyt2	802
Sumf1	674
Sumf2	-146
Smpd2	-414
Hexa	-484
Asah2	-759
Ctsa	-3076
Arsj	-3299
Smpd4	-3359
Esyt3	-7344

SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI

SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI
	1037
set	SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI
setSize	18
pANOVA	0.00383
s.dist	0.394
p.adjustANOVA	0.0307

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pigw	9250
Pigf	8812
Pigv	8682
Piga	8636
Pigx	8506
Pigq	6606
Pign	6041
Pigg	5972
Pigc	5803
Pigm	5616
Pigz	4578
Pigo	2824
Pigl	1731
Dpm2	768
Pigh	-1609
Pigp	-1967
Pigyl	-2299
Pigb	-5198

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pigw	9250
Pigf	8812
Pigv	8682
Piga	8636
Pigx	8506
Pigq	6606
Pign	6041
Pigg	5972
Pigc	5803
Pigm	5616
Pigz	4578
Pigo	2824
Pigl	1731
Dpm2	768
Pigh	-1609
Pigp	-1967
Pigyl	-2299
Pigb	-5198

SPHINGOLIPID METABOLISM

SPHINGOLIPID METABOLISM
	1008
set	SPHINGOLIPID METABOLISM
setSize	80
pANOVA	1.27e-09
s.dist	0.393
p.adjustANOVA	1.87e-07

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ormdl1	9234
B3galnt1	9230
Gla	9201
Arsa	8981
Neu3	8944
Galc	8882
Sptlc1	8849
Asah1	8647
Neu4	8522
Esyt1	8442
Arsb	8276
Fa2h	8124
Plpp3	7944
Degs1	7942
Ormdl2	7928
Sgms1	7852
B4galnt1	7463
Gba2	7449
Degs2	7360
Sptssa	7264

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ormdl1	9234
B3galnt1	9230
Gla	9201
Arsa	8981
Neu3	8944
Galc	8882
Sptlc1	8849
Asah1	8647
Neu4	8522
Esyt1	8442
Arsb	8276
Fa2h	8124
Plpp3	7944
Degs1	7942
Ormdl2	7928
Sgms1	7852
B4galnt1	7463
Gba2	7449
Degs2	7360
Sptssa	7264
Osbp	7103
Prkd1	7026
Plpp1	6837
Aldh3a2	6664
Ugt8a	6366
Psap	6328
Ugcg	6318
Prkd3	6316
Sgms2	6026
Cert1	6023
Gltp	6022
Cers5	5942
Cers1	5877
Sgpp1	5776
Csnk1g2	5732
Sgpp2	5582
Neu1	5420
Cerk	5234
Neu2	5146
Sgpl1	5129
Cptp	5086
Gm2a	5036
Ormdl3	4973
Sphk1	4789
Hexb	4729
Sptlc2	4652
Glb1l	4482
Cers6	4399
Sptlc3	4198
Vapb	4056
Gba	4021
Arsg	3793
Ppm1l	3788
Sptssb	3143
Cers2	3111
Arsk	3006
Prkd2	2917
Smpd1	2483
Spns2	2458
Smpd3	2172
Plpp2	1347
Glb1	1254
Esyt2	802
Sumf1	674
Sumf2	-146
Smpd2	-414
Hexa	-484
Asah2	-759
Acer2	-1956
Sphk2	-2021
Vapa	-2539
Kdsr	-2813
Aldh3b1	-2904
Ctsa	-3076
Acer3	-3257
Arsj	-3299
Smpd4	-3359
Samd8	-5797
Cers4	-7033
Esyt3	-7344

DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS

DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS
	221
set	DEFECTS OF CONTACT ACTIVATION SYSTEM CAS AND KALLIKREIN KININ SYSTEM KKS
setSize	11
pANOVA	0.0242
s.dist	-0.392
p.adjustANOVA	0.107

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gp1ba	-8198
Gp1bb	-8001
Ggcx	-6806
Tpst1	-5527
Serping1	-5474
Klkb1	-4297
F12	-2627
F8	-2132
Gp5	-310
Vwf	3862
Tpst2	7745

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gp1ba	-8198
Gp1bb	-8001
Ggcx	-6806
Tpst1	-5527
Serping1	-5474
Klkb1	-4297
F12	-2627
F8	-2132
Gp5	-310
Vwf	3862
Tpst2	7745

SPHINGOLIPID DE NOVO BIOSYNTHESIS

SPHINGOLIPID DE NOVO BIOSYNTHESIS
	1007
set	SPHINGOLIPID DE NOVO BIOSYNTHESIS
setSize	42
pANOVA	1.25e-05
s.dist	0.39
p.adjustANOVA	0.000522

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ormdl1	9234
Sptlc1	8849
Fa2h	8124
Plpp3	7944
Degs1	7942
Ormdl2	7928
Sgms1	7852
Degs2	7360
Sptssa	7264
Osbp	7103
Prkd1	7026
Plpp1	6837
Aldh3a2	6664
Prkd3	6316
Sgms2	6026
Cert1	6023
Cers5	5942
Cers1	5877
Sgpp1	5776
Csnk1g2	5732

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ormdl1	9234
Sptlc1	8849
Fa2h	8124
Plpp3	7944
Degs1	7942
Ormdl2	7928
Sgms1	7852
Degs2	7360
Sptssa	7264
Osbp	7103
Prkd1	7026
Plpp1	6837
Aldh3a2	6664
Prkd3	6316
Sgms2	6026
Cert1	6023
Cers5	5942
Cers1	5877
Sgpp1	5776
Csnk1g2	5732
Sgpp2	5582
Sgpl1	5129
Ormdl3	4973
Sphk1	4789
Sptlc2	4652
Cers6	4399
Sptlc3	4198
Vapb	4056
Ppm1l	3788
Sptssb	3143
Cers2	3111
Prkd2	2917
Spns2	2458
Plpp2	1347
Acer2	-1956
Sphk2	-2021
Vapa	-2539
Kdsr	-2813
Aldh3b1	-2904
Acer3	-3257
Samd8	-5797
Cers4	-7033

NUCLEOBASE BIOSYNTHESIS

NUCLEOBASE BIOSYNTHESIS
	654
set	NUCLEOBASE BIOSYNTHESIS
setSize	15
pANOVA	0.01
s.dist	0.384
p.adjustANOVA	0.061

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Paics	9163
Atic	7987
Adsl	7826
Gart	7723
Adss	6791
Impdh2	6200
Ppat	5022
Umps	4176
Impdh1	3875
Gmps	3087
Lhpp	2720
Adssl1	2686
Dhodh	140
Cad	-3152
Pfas	-4910

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Paics	9163
Atic	7987
Adsl	7826
Gart	7723
Adss	6791
Impdh2	6200
Ppat	5022
Umps	4176
Impdh1	3875
Gmps	3087
Lhpp	2720
Adssl1	2686
Dhodh	140
Cad	-3152
Pfas	-4910

COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN
	164
set	COHESIN LOADING ONTO CHROMATIN
setSize	10
pANOVA	0.0374
s.dist	0.38
p.adjustANOVA	0.143

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rad21	8790
Stag2	8475
Pds5b	8032
Stag1	7069
Mau2	3628
Smc1a	3616
Pds5a	3446
Wapl	1482
Nipbl	1043
Smc3	-6346

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rad21	8790
Stag2	8475
Pds5b	8032
Stag1	7069
Mau2	3628
Smc1a	3616
Pds5a	3446
Wapl	1482
Nipbl	1043
Smc3	-6346

CTLA4 INHIBITORY SIGNALING

CTLA4 INHIBITORY SIGNALING
	193
set	CTLA4 INHIBITORY SIGNALING
setSize	20
pANOVA	0.00362
s.dist	0.376
p.adjustANOVA	0.0296

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ptpn11	9296
Yes1	8654
Fyn	8650
Ppp2r5d	8038
Ppp2r5c	7442
Ppp2r5e	7405
Ppp2r5b	6724
Akt1	6662
Src	5680
Ppp2ca	5171
Ppp2r1a	4643
Akt3	4257
Ppp2r1b	3997
Lck	1852
Ppp2r5a	972
Cd86	361
Akt2	-508
Ppp2cb	-1872
Lyn	-2069
Cd80	-7687

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ptpn11	9296
Yes1	8654
Fyn	8650
Ppp2r5d	8038
Ppp2r5c	7442
Ppp2r5e	7405
Ppp2r5b	6724
Akt1	6662
Src	5680
Ppp2ca	5171
Ppp2r1a	4643
Akt3	4257
Ppp2r1b	3997
Lck	1852
Ppp2r5a	972
Cd86	361
Akt2	-508
Ppp2cb	-1872
Lyn	-2069
Cd80	-7687

ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY
	37
set	ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize	13
pANOVA	0.0198
s.dist	0.373
p.adjustANOVA	0.0944

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gnai1	8119
Adcy8	7381
Gnai2	6928
Gnai3	6827
Adcy3	5592
Adcy5	5062
Gnal	4031
Adcy1	3295
Adcy2	3030
Adcy9	1919
Adcy7	1718
Adcy4	-1197
Adcy6	-2493

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gnai1	8119
Adcy8	7381
Gnai2	6928
Gnai3	6827
Adcy3	5592
Adcy5	5062
Gnal	4031
Adcy1	3295
Adcy2	3030
Adcy9	1919
Adcy7	1718
Adcy4	-1197
Adcy6	-2493

PROCESSIVE SYNTHESIS ON THE LAGGING STRAND

PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
	744
set	PROCESSIVE SYNTHESIS ON THE LAGGING STRAND
setSize	15
pANOVA	0.0124
s.dist	0.373
p.adjustANOVA	0.071

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prim2	8549
Prim1	7456
Fen1	7372
Pola2	7148
Pcna	7097
Rpa1	6737
Pola1	5712
Pold2	2951
Pold3	2918
Rpa2	2323
Rpa3	2109
Pold1	1587
Dna2	1476
Pold4	-1605
Lig1	-3924

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prim2	8549
Prim1	7456
Fen1	7372
Pola2	7148
Pcna	7097
Rpa1	6737
Pola1	5712
Pold2	2951
Pold3	2918
Rpa2	2323
Rpa3	2109
Pold1	1587
Dna2	1476
Pold4	-1605
Lig1	-3924

RHOV GTPASE CYCLE

RHOV GTPASE CYCLE
	869
set	RHOV GTPASE CYCLE
setSize	33
pANOVA	0.000241
s.dist	0.369
p.adjustANOVA	0.00389

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tpm4	9047
Git1	8959
Nck1	8828
Pak2	8711
Sh3rf1	7833
Wdr6	7605
Peak1	7447
Pak1	7413
Depdc1b	6978
Arhgap12	6937
Sptan1	6656
Cltc	6291
Wasl	6063
Sptbn1	5623
Txnl1	5486
Pik3r1	5024
Usp9x	4932
Epha2	4386
Arhgef7	4333
Cdc42	4309

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tpm4	9047
Git1	8959
Nck1	8828
Pak2	8711
Sh3rf1	7833
Wdr6	7605
Peak1	7447
Pak1	7413
Depdc1b	6978
Arhgap12	6937
Sptan1	6656
Cltc	6291
Wasl	6063
Sptbn1	5623
Txnl1	5486
Pik3r1	5024
Usp9x	4932
Epha2	4386
Arhgef7	4333
Cdc42	4309
Pak6	4038
Dlg5	2786
Tpm3	2377
Vangl1	1703
Rhov	543
Iqgap1	25
Ccp110	-28
Myo9a	-37
Dst	-927
Nck2	-2459
Git2	-3117
Zfp512b	-5052
Cep97	-6532

PLATELET SENSITIZATION BY LDL

PLATELET SENSITIZATION BY LDL
	720
set	PLATELET SENSITIZATION BY LDL
setSize	15
pANOVA	0.0138
s.dist	0.367
p.adjustANOVA	0.0745

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ptpn11	9296
Pla2g4a	8646
Ppp2r5d	8038
Ppp2r5c	7442
Ppp2r5e	7405
Ppp2r5b	6724
Ppp2ca	5171
Ppp2r1a	4643
Ppp2r1b	3997
Mapk14	1963
Ppp2r5a	972
Lrp8	629
Ptpn6	-278
Ppp2cb	-1872
Pecam1	-5637

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ptpn11	9296
Pla2g4a	8646
Ppp2r5d	8038
Ppp2r5c	7442
Ppp2r5e	7405
Ppp2r5b	6724
Ppp2ca	5171
Ppp2r1a	4643
Ppp2r1b	3997
Mapk14	1963
Ppp2r5a	972
Lrp8	629
Ptpn6	-278
Ppp2cb	-1872
Pecam1	-5637

INSULIN PROCESSING

INSULIN PROCESSING
	456
set	INSULIN PROCESSING
setSize	24
pANOVA	0.00196
s.dist	0.365
p.adjustANOVA	0.0188

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pcsk1	9031
Myrip	8778
Exoc5	8427
Ero1a	8332
Exoc7	8318
Exoc3	8205
Slc30a7	6963
Slc30a5	6863
Pcsk2	6800
Cpe	6309
Myo5a	5840
Kif5a	5703
Exoc1	4048
Kif5c	3833
Exoc4	2467
Exoc2	1208
Exoc8	1072
Ero1b	927
Exoc6	86
Rab27a	-33

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pcsk1	9031
Myrip	8778
Exoc5	8427
Ero1a	8332
Exoc7	8318
Exoc3	8205
Slc30a7	6963
Slc30a5	6863
Pcsk2	6800
Cpe	6309
Myo5a	5840
Kif5a	5703
Exoc1	4048
Kif5c	3833
Exoc4	2467
Exoc2	1208
Exoc8	1072
Ero1b	927
Exoc6	86
Rab27a	-33
Slc30a6	-372
Kif5b	-2113
Stx1a	-4257
Vamp2	-5509

LDL CLEARANCE

LDL CLEARANCE
	516
set	LDL CLEARANCE
setSize	16
pANOVA	0.0115
s.dist	0.365
p.adjustANOVA	0.0671

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Soat1	8895
Lipa	7988
Nceh1	7697
Ap2b1	7444
Ap2a2	7134
Npc1	6395
Cltc	6291
Ldlrap1	4884
Ap2m1	4122
Ap2a1	3883
Lsr	3285
Clta	-54
Npc2	-185
Ldlr	-1174
Pcsk9	-1699
Ap2s1	-4313

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Soat1	8895
Lipa	7988
Nceh1	7697
Ap2b1	7444
Ap2a2	7134
Npc1	6395
Cltc	6291
Ldlrap1	4884
Ap2m1	4122
Ap2a1	3883
Lsr	3285
Clta	-54
Npc2	-185
Ldlr	-1174
Pcsk9	-1699
Ap2s1	-4313

FATTY ACYL COA BIOSYNTHESIS

FATTY ACYL COA BIOSYNTHESIS
	314
set	FATTY ACYL COA BIOSYNTHESIS
setSize	32
pANOVA	0.000406
s.dist	0.361
p.adjustANOVA	0.00569

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Acsbg1	9232
Ppt1	9171
Rpp14	9016
Acsl3	8989
Elovl2	8860
Acsl6	8499
Hsd17b12	7925
Acsl1	7586
Acsl4	7378
Hacd2	7234
Hacd4	6744
Elovl4	6612
Elovl1	6340
Elovl5	6153
Cbr4	6113
Scd2	4934
Acly	4805
Fasn	4777
Scd1	4689
Acsf3	4043

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Acsbg1	9232
Ppt1	9171
Rpp14	9016
Acsl3	8989
Elovl2	8860
Acsl6	8499
Hsd17b12	7925
Acsl1	7586
Acsl4	7378
Hacd2	7234
Hacd4	6744
Elovl4	6612
Elovl1	6340
Elovl5	6153
Cbr4	6113
Scd2	4934
Acly	4805
Fasn	4777
Scd1	4689
Acsf3	4043
Acsl5	3751
Elovl6	3694
Acaca	3651
Hacd3	1138
Slc25a1	-653
Ppt2	-1275
Slc27a3	-2394
Tecr	-4047
Morc2a	-4952
Hacd1	-5403
Elovl7	-5881
H2-Ke6	-6646

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL

SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
	1049
set	SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL
setSize	10
pANOVA	0.0493
s.dist	0.359
p.adjustANOVA	0.173

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Itpk1	9115
Nudt4	6774
Ppip5k2	6500
Ip6k1	6235
Ip6k3	5549
Ppip5k1	4291
Nudt11	4005
Nudt3	91
Ippk	-2232
Nudt10	-2948

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Itpk1	9115
Nudt4	6774
Ppip5k2	6500
Ip6k1	6235
Ip6k3	5549
Ppip5k1	4291
Nudt11	4005
Nudt3	91
Ippk	-2232
Nudt10	-2948

RECEPTOR MEDIATED MITOPHAGY

RECEPTOR MEDIATED MITOPHAGY
	777
set	RECEPTOR MEDIATED MITOPHAGY
setSize	11
pANOVA	0.0406
s.dist	0.357
p.adjustANOVA	0.152

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fundc1	8456
Atg5	7623
Atg12	7486
Pgam5	7265
Src	5680
Csnk2b	3202
Map1lc3b	2839
Ulk1	2740
Csnk2a1	-320
Csnk2a2	-490
Map1lc3a	-3610

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fundc1	8456
Atg5	7623
Atg12	7486
Pgam5	7265
Src	5680
Csnk2b	3202
Map1lc3b	2839
Ulk1	2740
Csnk2a1	-320
Csnk2a2	-490
Map1lc3a	-3610

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX

REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
	814
set	REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX
setSize	15
pANOVA	0.017
s.dist	0.356
p.adjustANOVA	0.0853

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dld	8678
Pdk3	8528
Pdha1	8186
Pdp1	8170
Rxra	7494
Pdhx	6298
Pdk2	6007
Pdhb	5209
Pdpr	4573
Ppard	2869
Pdk4	2120
Dlat	-619
Gstz1	-3089
Pdk1	-4308
Pdp2	-4491

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dld	8678
Pdk3	8528
Pdha1	8186
Pdp1	8170
Rxra	7494
Pdhx	6298
Pdk2	6007
Pdhb	5209
Pdpr	4573
Ppard	2869
Pdk4	2120
Dlat	-619
Gstz1	-3089
Pdk1	-4308
Pdp2	-4491

INTRA GOLGI TRAFFIC

INTRA GOLGI TRAFFIC
	486
set	INTRA GOLGI TRAFFIC
setSize	43
pANOVA	6.28e-05
s.dist	0.353
p.adjustANOVA	0.00145

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cog6	8754
Stx6	8556
Cux1	8537
Man1a	8443
Rab6a	8292
Cog1	7895
Snap29	7684
Cog4	7680
Vps45	7604
Vti1a	7461
Man2a1	6911
Cog2	6693
Napb	6585
Nsf	6550
Napa	6289
Napg	6084
Man1a2	5666
Ric1	5576
Rab30	5442
Golim4	5329

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cog6	8754
Stx6	8556
Cux1	8537
Man1a	8443
Rab6a	8292
Cog1	7895
Snap29	7684
Cog4	7680
Vps45	7604
Vti1a	7461
Man2a1	6911
Cog2	6693
Napb	6585
Nsf	6550
Napa	6289
Napg	6084
Man1a2	5666
Ric1	5576
Rab30	5442
Golim4	5329
Arf1	4881
Golga5	4558
Cog5	4246
Cyth3	4231
Cog3	3938
Gosr2	3125
Rab33b	2428
Stx5a	2302
Ykt6	2265
Man2a2	2234
Gosr1	2163
Rgp1	1998
Cog8	1608
Trip11	1607
Rab39	1406
Cyth1	447
Man1c1	264
Cog7	-2694
Stx16	-3185
Cyth2	-3562
Rab36	-4132
Bet1l	-6282
Cyth4	-7803

RHOF GTPASE CYCLE

RHOF GTPASE CYCLE
	863
set	RHOF GTPASE CYCLE
setSize	41
pANOVA	9.74e-05
s.dist	0.352
p.adjustANOVA	0.00205

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Farp1	9236
Snap23	9078
Tor1aip1	9062
Baiap2l1	8815
Esyt1	8442
Rhof	8157
Add3	8016
Sowahc	7962
Diaph1	7686
Cav1	7322
Depdc1b	6978
Arhgap32	6944
Arhgap12	6937
Tmpo	6444
Arhgap21	5835
Steap3	5651
Pik3r1	5024
Arhgap1	4996
Arhgap39	4865
Pik3r2	4622

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Farp1	9236
Snap23	9078
Tor1aip1	9062
Baiap2l1	8815
Esyt1	8442
Rhof	8157
Add3	8016
Sowahc	7962
Diaph1	7686
Cav1	7322
Depdc1b	6978
Arhgap32	6944
Arhgap12	6937
Tmpo	6444
Arhgap21	5835
Steap3	5651
Pik3r1	5024
Arhgap1	4996
Arhgap39	4865
Pik3r2	4622
Mtmr1	4448
Arhgap5	3725
Lmnb1	3654
Fam169a	3591
Akap12	3187
Diaph2	2912
Capzb	2842
Diaph3	1929
Vangl1	1703
Rab7	1273
Actn1	1213
Srgap2	1106
Syde1	-22
Basp1	-724
Slc4a7	-912
Mcam	-1153
Baiap2l2	-2596
Myo9b	-3015
Vamp3	-3112
Senp1	-3882
Actb	-7868

PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES

PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
	755
set	PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES
setSize	14
pANOVA	0.0238
s.dist	0.349
p.adjustANOVA	0.107

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Elmo1	8839
Rac1	8591
Rasa1	8289
Crk	6793
Arhgap35	6277
Ptk6	5618
Bcar1	4183
Kras	3745
Elmo2	3368
Dock1	2201
Rhoa	2051
Pxn	-949
Hras	-3603
Nras	-4341

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Elmo1	8839
Rac1	8591
Rasa1	8289
Crk	6793
Arhgap35	6277
Ptk6	5618
Bcar1	4183
Kras	3745
Elmo2	3368
Dock1	2201
Rhoa	2051
Pxn	-949
Hras	-3603
Nras	-4341

NUCLEOTIDE LIKE PURINERGIC RECEPTORS

NUCLEOTIDE LIKE PURINERGIC RECEPTORS
	658
set	NUCLEOTIDE LIKE PURINERGIC RECEPTORS
setSize	13
pANOVA	0.0301
s.dist	0.347
p.adjustANOVA	0.122

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gpr17	9197
P2ry1	9156
Adora1	8007
P2ry13	7043
Adora2a	5291
Lpar4	4674
Adora2b	3472
P2ry12	2821
P2ry6	2631
P2ry14	68
Lpar6	33
Adora3	-1046
P2ry2	-4090

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gpr17	9197
P2ry1	9156
Adora1	8007
P2ry13	7043
Adora2a	5291
Lpar4	4674
Adora2b	3472
P2ry12	2821
P2ry6	2631
P2ry14	68
Lpar6	33
Adora3	-1046
P2ry2	-4090

CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE

CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
	116
set	CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE
setSize	49
pANOVA	2.94e-05
s.dist	0.345
p.adjustANOVA	0.000865

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Rp2	9161
Lztfl1	8991
Exoc5	8427
Exoc7	8318
Exoc3	8205
Tcp1	8148
Unc119b	8116
Arf4	7436
Mchr1	7425
Arl6	7411
Mkks	7250
Bbs1	7110
Rab3ip	7096
Cct3	6618
Bbs7	6425
Rab11fip3	6241
Pde6d	6158
Cct5	6045
Gbf1	5754
Ttc8	5746

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Rp2	9161
Lztfl1	8991
Exoc5	8427
Exoc7	8318
Exoc3	8205
Tcp1	8148
Unc119b	8116
Arf4	7436
Mchr1	7425
Arl6	7411
Mkks	7250
Bbs1	7110
Rab3ip	7096
Cct3	6618
Bbs7	6425
Rab11fip3	6241
Pde6d	6158
Cct5	6045
Gbf1	5754
Ttc8	5746
Bbs10	5621
Bbs4	5540
Cct4	5520
Smo	5122
Cys1	4281
Rab11a	4161
Exoc1	4048
Cct2	3787
Sstr3	3325
Cct8	3153
Rab8a	2930
Arl13b	2806
Exoc4	2467
Exoc2	1208
Exoc8	1072
Bbs2	306
Exoc6	86
Inpp5e	44
Asap1	21
Bbs12	-115
Pkd2	-195
Bbs9	-196
Bbip1	-690
Cnga4	-1815
Arl3	-2282
Pkd1	-2879
Nphp3	-3678
Bbs5	-4881
Cngb1	-8095

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-55                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.3      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.1.3          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] prettyunits_1.1.1      colorspace_2.0-2       blob_1.2.2            
##  [22] rvest_1.0.2            haven_2.4.3            xfun_0.29             
##  [25] crayon_1.4.2           RCurl_1.98-1.6         jsonlite_1.7.3        
##  [28] genefilter_1.74.1      survival_3.2-13        glue_1.6.1            
##  [31] polyclip_1.10-0        gtable_0.3.0           zlibbioc_1.38.0       
##  [34] XVector_0.32.0         webshot_0.5.2          DelayedArray_0.18.0   
##  [37] scales_1.1.1           DBI_1.1.2              Rcpp_1.0.8            
##  [40] progress_1.2.2         viridisLite_0.4.0      xtable_1.8-4          
##  [43] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.2            
##  [46] RColorBrewer_1.1-2     ellipsis_0.3.2         farver_2.1.0          
##  [49] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.8          
##  [52] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.4        
##  [55] utf8_1.2.2             labeling_0.4.2         tidyselect_1.1.1      
##  [58] rlang_1.0.1            later_1.3.0            AnnotationDbi_1.54.1  
##  [61] munsell_0.5.0          cellranger_1.1.0       tools_4.1.3           
##  [64] cachem_1.0.6           cli_3.1.1              generics_0.1.2        
##  [67] RSQLite_2.2.9          broom_0.7.12           evaluate_0.14         
##  [70] fastmap_1.1.0          yaml_2.2.2             knitr_1.37            
##  [73] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [76] KEGGREST_1.32.0        mime_0.12              xml2_1.3.3            
##  [79] compiler_4.1.3         rstudioapi_0.13        png_0.1-7             
##  [82] reprex_2.0.1           geneplotter_1.70.0     bslib_0.3.1           
##  [85] stringi_1.7.6          highr_0.9              desc_1.4.0            
##  [88] lattice_0.20-45        Matrix_1.4-0           vctrs_0.3.8           
##  [91] pillar_1.7.0           lifecycle_1.0.1        jquerylib_0.1.4       
##  [94] data.table_1.14.2      bitops_1.0-7           httpuv_1.6.5          
##  [97] R6_2.5.1               promises_1.2.0.1       KernSmooth_2.23-20    
## [100] gridExtra_2.3          assertthat_0.2.1       rprojroot_2.0.2       
## [103] withr_2.4.3            GenomeInfoDbData_1.2.6 hms_1.1.1             
## [106] grid_4.1.3             rmarkdown_2.11         shiny_1.7.1           
## [109] lubridate_1.8.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports