date generated: 2022-03-15

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                        x
## 0610009B22Rik -1.1332185
## 0610009E02Rik -0.3290659
## 0610009L18Rik  0.1306738
## 0610010K14Rik -0.3126674
## 0610012G03Rik -0.2034285
## 0610030E20Rik -0.5747514
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17372
duplicated_genes_present 0
num_profile_genes_in_sets 8443
num_profile_genes_not_in_sets 8929

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene sets metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 425
num_genesets_included 1179

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.27e-05 0.611 5.57e-04
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 1.98e-03 -0.565 2.21e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 3.97e-03 0.502 3.77e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.70e-03 -0.492 4.29e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 7.94e-03 0.485 6.24e-02
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 2.38e-04 0.475 5.02e-03
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 9.56e-03 0.473 7.12e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 6.90e-05 0.451 2.09e-03
RUNX3 REGULATES NOTCH SIGNALING 13 4.89e-03 0.451 4.40e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.61e-04 0.446 8.99e-03
NOTCH HLH TRANSCRIPTION PATHWAY 28 5.01e-05 0.443 1.64e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.70e-02 0.436 1.02e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.47e-04 0.431 6.45e-03
MITOCHONDRIAL TRANSLATION 93 7.30e-13 -0.430 4.30e-10
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 6.19e-05 -0.430 1.92e-03
P75NTR REGULATES AXONOGENESIS 10 1.96e-02 -0.426 1.13e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 1.33e-03 0.425 1.65e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 1.41e-02 0.409 9.16e-02
CRISTAE FORMATION 31 8.21e-05 -0.409 2.31e-03
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 6.28e-03 0.408 5.33e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.53e-03 -0.400 2.69e-02
SIGNALING BY LEPTIN 10 2.84e-02 0.400 1.43e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.41e-05 0.396 9.48e-04
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.18e-04 0.393 3.17e-03
INTERLEUKIN 6 SIGNALING 10 3.18e-02 0.392 1.51e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 4.08e-03 -0.391 3.84e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.48e-02 -0.386 1.56e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 20 3.10e-03 -0.382 3.12e-02
RESPIRATORY ELECTRON TRANSPORT 102 2.96e-11 -0.381 8.73e-09
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 2.90e-02 -0.380 1.45e-01
ASPARTATE AND ASPARAGINE METABOLISM 11 2.92e-02 -0.380 1.45e-01
PHASE 2 PLATEAU PHASE 12 2.28e-02 0.380 1.22e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 9.80e-04 -0.373 1.33e-02
COMPLEX I BIOGENESIS 56 1.98e-06 -0.367 1.17e-04
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 1.75e-02 0.367 1.03e-01
ACTIVATION OF SMO 16 1.13e-02 0.366 7.88e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 2.28e-02 0.365 1.22e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 1.04e-03 0.365 1.37e-02
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 15 1.51e-02 0.362 9.54e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.83e-12 -0.362 1.11e-09
CITRIC ACID CYCLE TCA CYCLE 22 3.40e-03 -0.361 3.31e-02
MITOCHONDRIAL PROTEIN IMPORT 63 7.97e-07 -0.360 6.26e-05
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 3.22e-02 0.357 1.52e-01
CHOLESTEROL BIOSYNTHESIS 24 2.49e-03 -0.357 2.67e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.30e-02 0.356 1.53e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 1.73e-02 0.355 1.03e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 1.52e-03 0.353 1.81e-02
PENTOSE PHOSPHATE PATHWAY 13 2.85e-02 -0.351 1.43e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.52e-02 0.351 9.54e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 2.92e-02 0.349 1.45e-01


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 1.27e-05 6.11e-01 5.57e-04
ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN 10 1.98e-03 -5.65e-01 2.21e-02
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 3.97e-03 5.02e-01 3.77e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.70e-03 -4.92e-01 4.29e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 7.94e-03 4.85e-01 6.24e-02
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 2.38e-04 4.75e-01 5.02e-03
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 9.56e-03 4.73e-01 7.12e-02
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 6.90e-05 4.51e-01 2.09e-03
RUNX3 REGULATES NOTCH SIGNALING 13 4.89e-03 4.51e-01 4.40e-02
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 5.61e-04 4.46e-01 8.99e-03
NOTCH HLH TRANSCRIPTION PATHWAY 28 5.01e-05 4.43e-01 1.64e-03
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 1.70e-02 4.36e-01 1.02e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 3.47e-04 4.31e-01 6.45e-03
MITOCHONDRIAL TRANSLATION 93 7.30e-13 -4.30e-01 4.30e-10
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 6.19e-05 -4.30e-01 1.92e-03
P75NTR REGULATES AXONOGENESIS 10 1.96e-02 -4.26e-01 1.13e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 19 1.33e-03 4.25e-01 1.65e-02
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 1.41e-02 4.09e-01 9.16e-02
CRISTAE FORMATION 31 8.21e-05 -4.09e-01 2.31e-03
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 6.28e-03 4.08e-01 5.33e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 2.53e-03 -4.00e-01 2.69e-02
SIGNALING BY LEPTIN 10 2.84e-02 4.00e-01 1.43e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 2.41e-05 3.96e-01 9.48e-04
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 1.18e-04 3.93e-01 3.17e-03
INTERLEUKIN 6 SIGNALING 10 3.18e-02 3.92e-01 1.51e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 4.08e-03 -3.91e-01 3.84e-02
APOPTOSIS INDUCED DNA FRAGMENTATION 10 3.48e-02 -3.86e-01 1.56e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 20 3.10e-03 -3.82e-01 3.12e-02
RESPIRATORY ELECTRON TRANSPORT 102 2.96e-11 -3.81e-01 8.73e-09
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 11 2.90e-02 -3.80e-01 1.45e-01
ASPARTATE AND ASPARAGINE METABOLISM 11 2.92e-02 -3.80e-01 1.45e-01
PHASE 2 PLATEAU PHASE 12 2.28e-02 3.80e-01 1.22e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 9.80e-04 -3.73e-01 1.33e-02
COMPLEX I BIOGENESIS 56 1.98e-06 -3.67e-01 1.17e-04
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 1.75e-02 3.67e-01 1.03e-01
ACTIVATION OF SMO 16 1.13e-02 3.66e-01 7.88e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 2.28e-02 3.65e-01 1.22e-01
INTERACTION BETWEEN L1 AND ANKYRINS 27 1.04e-03 3.65e-01 1.37e-02
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 15 1.51e-02 3.62e-01 9.54e-02
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 2.83e-12 -3.62e-01 1.11e-09
CITRIC ACID CYCLE TCA CYCLE 22 3.40e-03 -3.61e-01 3.31e-02
MITOCHONDRIAL PROTEIN IMPORT 63 7.97e-07 -3.60e-01 6.26e-05
ORGANIC CATION ANION ZWITTERION TRANSPORT 12 3.22e-02 3.57e-01 1.52e-01
CHOLESTEROL BIOSYNTHESIS 24 2.49e-03 -3.57e-01 2.67e-02
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.30e-02 3.56e-01 1.53e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 1.73e-02 3.55e-01 1.03e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 27 1.52e-03 3.53e-01 1.81e-02
PENTOSE PHOSPHATE PATHWAY 13 2.85e-02 -3.51e-01 1.43e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 1.52e-02 3.51e-01 9.54e-02
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 2.92e-02 3.49e-01 1.45e-01
LGI ADAM INTERACTIONS 14 2.38e-02 3.49e-01 1.26e-01
FGFR2 LIGAND BINDING AND ACTIVATION 13 3.07e-02 -3.46e-01 1.49e-01
EARLY PHASE OF HIV LIFE CYCLE 13 3.15e-02 -3.44e-01 1.50e-01
CS DS DEGRADATION 14 2.73e-02 3.41e-01 1.38e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 5.49e-02 3.34e-01 2.08e-01
RORA ACTIVATES GENE EXPRESSION 18 1.41e-02 3.34e-01 9.16e-02
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 4.36e-14 -3.34e-01 5.15e-11
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 9.82e-03 -3.34e-01 7.15e-02
SCAVENGING OF HEME FROM PLASMA 10 6.92e-02 -3.32e-01 2.44e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 1.41e-03 -3.31e-01 1.70e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 7.04e-02 -3.30e-01 2.44e-01
PROCESSING OF SMDT1 16 2.23e-02 -3.30e-01 1.22e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 40 3.45e-04 3.27e-01 6.45e-03
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 7.41e-02 3.26e-01 2.52e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 7.41e-02 3.26e-01 2.52e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 1.12e-02 3.20e-01 7.88e-02
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 2.42e-02 3.16e-01 1.27e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 3.44e-02 3.16e-01 1.56e-01
ORC1 REMOVAL FROM CHROMATIN 69 5.97e-06 -3.15e-01 3.20e-04
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 7.06e-02 3.15e-01 2.44e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 14 4.17e-02 3.14e-01 1.74e-01
ACTIVATION OF PPARGC1A PGC 1ALPHA BY PHOSPHORYLATION 10 8.69e-02 -3.13e-01 2.71e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.77e-02 -3.12e-01 2.71e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 88 4.77e-07 -3.11e-01 4.32e-05
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 7.45e-02 3.11e-01 2.52e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 5.27e-02 -3.10e-01 2.06e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 6.39e-02 -3.09e-01 2.32e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.68e-02 -3.09e-01 1.02e-01
METALLOPROTEASE DUBS 25 7.73e-03 -3.08e-01 6.16e-02
BIOTIN TRANSPORT AND METABOLISM 11 7.83e-02 3.07e-01 2.57e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 84 1.66e-06 -3.02e-01 1.03e-04
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 25 9.30e-03 3.01e-01 6.99e-02
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 3.35e-03 3.00e-01 3.29e-02
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 59 8.24e-05 -2.96e-01 2.31e-03
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 19 2.54e-02 -2.96e-01 1.30e-01
INTERLEUKIN 7 SIGNALING 19 2.57e-02 2.96e-01 1.30e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 66 3.70e-05 -2.94e-01 1.36e-03
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.95e-04 -2.93e-01 4.34e-03
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY 10 1.09e-01 2.93e-01 3.13e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 6.20e-03 2.89e-01 5.30e-02
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 72 2.58e-05 -2.87e-01 9.81e-04
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 1.16e-01 2.87e-01 3.25e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 27 1.03e-02 -2.85e-01 7.44e-02
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 69 4.33e-05 -2.85e-01 1.55e-03
SIGNALING BY NOTCH3 48 6.66e-04 2.84e-01 9.85e-03
DNA REPLICATION PRE INITIATION 81 1.02e-05 -2.84e-01 4.60e-04
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 21 2.48e-02 -2.83e-01 1.29e-01
HIV TRANSCRIPTION INITIATION 45 1.05e-03 -2.82e-01 1.38e-02
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 8.84e-03 2.81e-01 6.68e-02
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 48 8.05e-04 -2.80e-01 1.13e-02
METABOLISM OF POLYAMINES 59 2.04e-04 -2.80e-01 4.45e-03
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 9.37e-02 -2.79e-01 2.84e-01
ELASTIC FIBRE FORMATION 38 3.01e-03 2.78e-01 3.06e-02
G PROTEIN ACTIVATION 23 2.11e-02 2.78e-01 1.19e-01
INTERLEUKIN 12 SIGNALING 36 3.93e-03 -2.78e-01 3.77e-02
PHOSPHORYLATION OF THE APC C 18 4.15e-02 -2.78e-01 1.74e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 3.74e-02 -2.76e-01 1.63e-01
RECEPTOR MEDIATED MITOPHAGY 11 1.13e-01 -2.76e-01 3.21e-01
MET ACTIVATES RAP1 AND RAC1 10 1.33e-01 -2.75e-01 3.50e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 41 2.40e-03 -2.74e-01 2.59e-02
DEGRADATION OF DVL 57 3.55e-04 -2.74e-01 6.45e-03
TIGHT JUNCTION INTERACTIONS 17 5.11e-02 -2.73e-01 2.03e-01
CRMPS IN SEMA3A SIGNALING 16 5.97e-02 2.72e-01 2.21e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 65 1.55e-04 -2.71e-01 3.73e-03
SIGNALING BY NTRK3 TRKC 17 5.39e-02 2.70e-01 2.07e-01
PLASMA LIPOPROTEIN ASSEMBLY 11 1.22e-01 2.70e-01 3.36e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 55 5.72e-04 -2.69e-01 8.99e-03
DNA REPLICATION 123 2.79e-07 -2.68e-01 2.99e-05
REGULATION OF TLR BY ENDOGENOUS LIGAND 14 8.22e-02 -2.68e-01 2.62e-01
G1 S DNA DAMAGE CHECKPOINTS 67 1.50e-04 -2.68e-01 3.70e-03
REGULATION OF IFNA SIGNALING 12 1.09e-01 2.67e-01 3.14e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 1.31e-02 -2.66e-01 8.68e-02
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 1.91e-02 -2.66e-01 1.11e-01
PROTEIN UBIQUITINATION 70 1.24e-04 -2.65e-01 3.25e-03
SIGNALING BY NOTCH2 33 8.37e-03 2.65e-01 6.49e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 61 3.53e-04 -2.65e-01 6.45e-03
REPRESSION OF WNT TARGET GENES 14 8.67e-02 2.64e-01 2.71e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 4.76e-02 -2.63e-01 1.93e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 80 4.94e-05 -2.63e-01 1.64e-03
STABILIZATION OF P53 56 7.10e-04 -2.62e-01 1.01e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 1.05e-02 2.61e-01 7.54e-02
N GLYCAN ANTENNAE ELONGATION 15 7.99e-02 2.61e-01 2.59e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 6.24e-02 2.61e-01 2.29e-01
REGULATION OF TNFR1 SIGNALING 34 8.48e-03 2.61e-01 6.50e-02
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 1.87e-03 2.60e-01 2.14e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 1.36e-03 -2.59e-01 1.66e-02
FCERI MEDIATED NF KB ACTIVATION 78 7.53e-05 -2.59e-01 2.22e-03
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 71 1.63e-04 -2.59e-01 3.77e-03
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 5.77e-02 2.58e-01 2.16e-01
S PHASE 155 2.87e-08 -2.58e-01 3.77e-06
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 3.63e-02 -2.58e-01 1.62e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.24e-01 2.57e-01 3.39e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 84 4.82e-05 -2.57e-01 1.64e-03
CELLULAR RESPONSE TO HYPOXIA 74 1.47e-04 -2.55e-01 3.69e-03
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 14 1.01e-01 2.53e-01 2.98e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 1.46e-01 2.53e-01 3.74e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS 19 5.71e-02 -2.52e-01 2.15e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 3.65e-02 -2.52e-01 1.62e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 1.68e-01 -2.52e-01 3.98e-01
HYALURONAN METABOLISM 15 9.16e-02 2.52e-01 2.79e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 24 3.30e-02 -2.51e-01 1.53e-01
CYTOSOLIC TRNA AMINOACYLATION 24 3.36e-02 -2.51e-01 1.54e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 5.46e-02 2.48e-01 2.08e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 2.56e-03 2.47e-01 2.69e-02
COHESIN LOADING ONTO CHROMATIN 10 1.77e-01 -2.47e-01 4.13e-01
CD28 DEPENDENT VAV1 PATHWAY 11 1.59e-01 -2.45e-01 3.88e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 22 4.68e-02 -2.45e-01 1.91e-01
RAB GERANYLGERANYLATION 58 1.26e-03 -2.45e-01 1.59e-02
G2 M DNA DAMAGE CHECKPOINT 66 6.16e-04 -2.44e-01 9.43e-03
DEGRADATION OF GLI1 BY THE PROTEASOME 59 1.23e-03 -2.43e-01 1.56e-02
FGFR1 LIGAND BINDING AND ACTIVATION 10 1.85e-01 -2.42e-01 4.22e-01
G2 M CHECKPOINTS 135 1.19e-06 -2.42e-01 8.22e-05
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 2.19e-02 2.42e-01 1.22e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 2.23e-02 -2.41e-01 1.22e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 1.33e-01 -2.41e-01 3.50e-01
NEPHRIN FAMILY INTERACTIONS 23 4.57e-02 2.41e-01 1.88e-01
PEXOPHAGY 11 1.67e-01 2.40e-01 3.98e-01
REGULATION OF BACH1 ACTIVITY 11 1.68e-01 -2.40e-01 3.98e-01
PI 3K CASCADE FGFR2 17 8.74e-02 -2.40e-01 2.71e-01
PYRUVATE METABOLISM 27 3.30e-02 -2.37e-01 1.53e-01
PROTEIN LOCALIZATION 157 3.24e-07 -2.36e-01 3.18e-05
DCC MEDIATED ATTRACTIVE SIGNALING 14 1.26e-01 2.36e-01 3.43e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 1.56e-01 -2.36e-01 3.87e-01
DEGRADATION OF AXIN 55 2.71e-03 -2.34e-01 2.83e-02
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 9.62e-03 2.34e-01 7.12e-02
FRS MEDIATED FGFR2 SIGNALING 19 7.79e-02 -2.34e-01 2.57e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 2.96e-02 -2.33e-01 1.46e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 1.81e-01 2.33e-01 4.18e-01
RND2 GTPASE CYCLE 39 1.19e-02 2.33e-01 8.09e-02
EPHRIN SIGNALING 19 8.08e-02 2.31e-01 2.60e-01
HDMS DEMETHYLATE HISTONES 26 4.12e-02 2.31e-01 1.74e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 4.31e-03 -2.31e-01 4.00e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 1.50e-01 -2.30e-01 3.79e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 1.12e-01 -2.30e-01 3.18e-01
FORMATION OF APOPTOSOME 10 2.09e-01 -2.30e-01 4.59e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 8.36e-02 -2.29e-01 2.65e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 2.27e-02 -2.29e-01 1.22e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 1.38e-01 2.29e-01 3.57e-01
RND3 GTPASE CYCLE 38 1.45e-02 2.29e-01 9.30e-02
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 25 4.76e-02 -2.29e-01 1.93e-01
PROCESSING AND ACTIVATION OF SUMO 10 2.10e-01 -2.29e-01 4.61e-01
GLUTATHIONE CONJUGATION 29 3.33e-02 -2.28e-01 1.53e-01
SIGNALING BY NOTCH1 75 6.68e-04 2.27e-01 9.85e-03
MITOTIC G1 PHASE AND G1 S TRANSITION 141 3.44e-06 -2.27e-01 1.93e-04
TRANSLESION SYNTHESIS BY POLK 17 1.06e-01 -2.26e-01 3.09e-01
CA2 PATHWAY 58 2.87e-03 2.26e-01 2.94e-02
PROTEIN METHYLATION 17 1.06e-01 -2.26e-01 3.09e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 1.29e-01 -2.26e-01 3.49e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 1.74e-02 2.26e-01 1.03e-01
RHOB GTPASE CYCLE 69 1.23e-03 2.25e-01 1.56e-02
RHOC GTPASE CYCLE 74 8.54e-04 2.24e-01 1.17e-02
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 3.11e-02 -2.24e-01 1.50e-01
CLEC7A DECTIN 1 SIGNALING 96 1.61e-04 -2.23e-01 3.77e-03
SEPARATION OF SISTER CHROMATIDS 169 6.23e-07 -2.22e-01 5.25e-05
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 5.24e-03 -2.22e-01 4.61e-02
BRANCHED CHAIN AMINO ACID CATABOLISM 21 7.92e-02 -2.21e-01 2.58e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 30 3.66e-02 2.20e-01 1.62e-01
INSULIN RECEPTOR RECYCLING 20 8.80e-02 -2.20e-01 2.71e-01
CELL CYCLE CHECKPOINTS 245 2.95e-09 -2.20e-01 6.95e-07
REGULATION OF INSULIN SECRETION 72 1.23e-03 2.20e-01 1.56e-02
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 70 1.60e-03 -2.18e-01 1.88e-02
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.92e-01 2.17e-01 4.34e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 1.92e-01 -2.17e-01 4.34e-01
PERK REGULATES GENE EXPRESSION 28 4.78e-02 -2.16e-01 1.94e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 12 1.96e-01 -2.16e-01 4.39e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 4.28e-03 2.15e-01 4.00e-02
SIGNALING BY FGFR2 IN DISEASE 37 2.39e-02 -2.15e-01 1.26e-01
CELLULAR HEXOSE TRANSPORT 11 2.18e-01 2.14e-01 4.74e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 7.59e-02 2.14e-01 2.54e-01
TNF SIGNALING 43 1.53e-02 2.14e-01 9.54e-02
MUCOPOLYSACCHARIDOSES 11 2.21e-01 2.13e-01 4.74e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 2.21e-01 -2.13e-01 4.74e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 7.66e-02 2.13e-01 2.55e-01
GP1B IX V ACTIVATION SIGNALLING 11 2.21e-01 2.13e-01 4.74e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 1.57e-02 2.13e-01 9.72e-02
NRAGE SIGNALS DEATH THROUGH JNK 56 5.85e-03 2.13e-01 5.07e-02
RMTS METHYLATE HISTONE ARGININES 42 1.71e-02 2.13e-01 1.02e-01
G ALPHA 12 13 SIGNALLING EVENTS 76 1.36e-03 2.13e-01 1.66e-02
INTERLEUKIN 12 FAMILY SIGNALING 43 1.60e-02 -2.12e-01 9.80e-02
PYRIMIDINE CATABOLISM 10 2.47e-01 -2.12e-01 5.03e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 14 1.72e-01 -2.11e-01 4.03e-01
INTEGRATION OF ENERGY METABOLISM 100 2.76e-04 2.11e-01 5.52e-03
RHO GTPASES ACTIVATE NADPH OXIDASES 22 8.77e-02 -2.10e-01 2.71e-01
DERMATAN SULFATE BIOSYNTHESIS 11 2.29e-01 2.10e-01 4.80e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 1.14e-01 2.09e-01 3.22e-01
MRNA CAPPING 29 5.18e-02 -2.09e-01 2.04e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 1.63e-01 2.08e-01 3.92e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 2.55e-01 2.08e-01 5.14e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.29e-02 -2.08e-01 8.61e-02
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 1.51e-01 -2.07e-01 3.79e-01
DARPP 32 EVENTS 23 8.62e-02 -2.07e-01 2.70e-01
CDC42 GTPASE CYCLE 155 9.19e-06 2.07e-01 4.36e-04
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 49 1.28e-02 2.06e-01 8.61e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 1.23e-01 2.05e-01 3.38e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 37 3.14e-02 -2.04e-01 1.50e-01
G0 AND EARLY G1 25 7.71e-02 -2.04e-01 2.55e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.36e-01 -2.03e-01 3.54e-01
NEUROTRANSMITTER RELEASE CYCLE 49 1.40e-02 2.03e-01 9.16e-02
G1 S SPECIFIC TRANSCRIPTION 27 7.02e-02 -2.01e-01 2.44e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 1.59e-02 2.01e-01 9.79e-02
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 61 6.58e-03 -2.01e-01 5.42e-02
INTERLEUKIN 15 SIGNALING 13 2.10e-01 2.01e-01 4.61e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 6.24e-02 2.00e-01 2.29e-01
NEUREXINS AND NEUROLIGINS 54 1.12e-02 2.00e-01 7.88e-02
RET SIGNALING 36 3.86e-02 1.99e-01 1.66e-01
INTEGRIN SIGNALING 24 9.16e-02 1.99e-01 2.79e-01
OTHER SEMAPHORIN INTERACTIONS 19 1.33e-01 1.99e-01 3.50e-01
G ALPHA S SIGNALLING EVENTS 109 3.54e-04 1.98e-01 6.45e-03
C TYPE LECTIN RECEPTORS CLRS 115 2.47e-04 -1.98e-01 5.02e-03
FORMATION OF INCISION COMPLEX IN GG NER 43 2.49e-02 -1.98e-01 1.29e-01
INTERLEUKIN 20 FAMILY SIGNALING 14 2.01e-01 1.98e-01 4.48e-01
PRE NOTCH PROCESSING IN GOLGI 17 1.59e-01 1.97e-01 3.88e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 2.38e-01 1.97e-01 4.94e-01
RA BIOSYNTHESIS PATHWAY 14 2.03e-01 -1.97e-01 4.52e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 63 7.02e-03 -1.96e-01 5.75e-02
RESOLUTION OF D LOOP STRUCTURES 31 5.85e-02 -1.96e-01 2.18e-01
MITOTIC TELOPHASE CYTOKINESIS 13 2.21e-01 -1.96e-01 4.74e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 1.30e-01 -1.96e-01 3.49e-01
REGULATION OF PTEN STABILITY AND ACTIVITY 69 4.95e-03 -1.96e-01 4.42e-02
PLASMA LIPOPROTEIN REMODELING 13 2.22e-01 1.95e-01 4.74e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 28 7.36e-02 -1.95e-01 2.51e-01
TRAFFICKING OF AMPA RECEPTORS 31 5.99e-02 1.95e-01 2.21e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 52 1.52e-02 1.95e-01 9.54e-02
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 27 8.04e-02 1.94e-01 2.60e-01
PRE NOTCH EXPRESSION AND PROCESSING 62 8.19e-03 1.94e-01 6.40e-02
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 2.25e-01 1.94e-01 4.78e-01
CHONDROITIN SULFATE BIOSYNTHESIS 18 1.55e-01 1.94e-01 3.85e-01
HS GAG DEGRADATION 22 1.16e-01 1.93e-01 3.25e-01
MITOTIC METAPHASE AND ANAPHASE 210 1.41e-06 -1.93e-01 9.21e-05
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 86 1.98e-03 -1.93e-01 2.21e-02
RHOV GTPASE CYCLE 33 5.51e-02 1.93e-01 2.08e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.46e-01 -1.93e-01 3.73e-01
TRANSLATION 287 2.17e-08 -1.92e-01 3.66e-06
RHOBTB3 ATPASE CYCLE 10 2.94e-01 -1.92e-01 5.60e-01
INTERLEUKIN 37 SIGNALING 18 1.59e-01 1.92e-01 3.88e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 7.93e-02 -1.92e-01 2.58e-01
RHOU GTPASE CYCLE 34 5.33e-02 1.92e-01 2.07e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 24 1.05e-01 1.91e-01 3.07e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 1.86e-01 -1.91e-01 4.24e-01
REGULATION OF RAS BY GAPS 68 6.48e-03 -1.91e-01 5.39e-02
MITOCHONDRIAL FATTY ACID BETA OXIDATION 34 5.41e-02 -1.91e-01 2.07e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 1.62e-01 -1.90e-01 3.91e-01
SIGNALING BY FGFR2 IIIA TM 19 1.51e-01 -1.90e-01 3.79e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 1.07e-01 1.90e-01 3.09e-01
TCR SIGNALING 104 8.30e-04 -1.90e-01 1.15e-02
FORMATION OF TC NER PRE INCISION COMPLEX 53 1.71e-02 -1.89e-01 1.02e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 25 1.01e-01 1.89e-01 2.98e-01
GABA B RECEPTOR ACTIVATION 40 3.83e-02 1.89e-01 1.66e-01
METHYLATION 11 2.78e-01 -1.89e-01 5.46e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 28 8.43e-02 1.89e-01 2.66e-01
PHASE II CONJUGATION OF COMPOUNDS 63 9.72e-03 -1.88e-01 7.12e-02
ION TRANSPORT BY P TYPE ATPASES 49 2.33e-02 1.87e-01 1.24e-01
RHOA GTPASE CYCLE 144 1.06e-04 1.87e-01 2.90e-03
INTERLEUKIN 2 FAMILY SIGNALING 33 6.27e-02 1.87e-01 2.29e-01
COLLAGEN CHAIN TRIMERIZATION 41 3.91e-02 -1.86e-01 1.68e-01
IRON UPTAKE AND TRANSPORT 52 2.03e-02 -1.86e-01 1.16e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 2.86e-01 -1.86e-01 5.54e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 1.31e-01 1.86e-01 3.49e-01
CYTOPROTECTION BY HMOX1 120 4.59e-04 -1.85e-01 8.07e-03
ONCOGENE INDUCED SENESCENCE 32 6.99e-02 1.85e-01 2.44e-01
SULFUR AMINO ACID METABOLISM 23 1.29e-01 -1.83e-01 3.49e-01
IRAK4 DEFICIENCY TLR2 4 15 2.22e-01 -1.82e-01 4.74e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.55e-02 -1.82e-01 2.09e-01
MITOTIC G2 G2 M PHASES 187 1.84e-05 -1.82e-01 7.48e-04
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 1.31e-01 -1.82e-01 3.49e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 9.12e-02 1.81e-01 2.79e-01
HOST INTERACTIONS OF HIV FACTORS 128 4.03e-04 -1.81e-01 7.21e-03
PHASE 0 RAPID DEPOLARISATION 28 9.75e-02 1.81e-01 2.92e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 1.33e-01 1.81e-01 3.50e-01
GLYCOSPHINGOLIPID METABOLISM 38 5.42e-02 -1.81e-01 2.07e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 1.98e-01 -1.80e-01 4.44e-01
METABOLISM OF PORPHYRINS 19 1.75e-01 -1.80e-01 4.09e-01
FC EPSILON RECEPTOR FCERI SIGNALING 125 5.20e-04 -1.80e-01 8.75e-03
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 39 5.20e-02 1.80e-01 2.04e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 9.96e-02 -1.80e-01 2.96e-01
RESOLUTION OF SISTER CHROMATID COHESION 103 1.67e-03 -1.79e-01 1.94e-02
HDR THROUGH MMEJ ALT NHEJ 10 3.26e-01 -1.79e-01 5.92e-01
METABOLISM OF STEROID HORMONES 21 1.56e-01 -1.79e-01 3.86e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 3.04e-01 -1.79e-01 5.70e-01
FCGR3A MEDIATED IL10 SYNTHESIS 33 7.55e-02 1.79e-01 2.54e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 1.15e-01 1.79e-01 3.24e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 1.08e-01 1.79e-01 3.13e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 84 4.73e-03 -1.78e-01 4.29e-02
MITOTIC SPINDLE CHECKPOINT 98 2.29e-03 -1.78e-01 2.50e-02
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 2.06e-01 -1.77e-01 4.55e-01
INTERLEUKIN 6 FAMILY SIGNALING 21 1.61e-01 1.77e-01 3.91e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 4.99e-03 1.76e-01 4.42e-02
REGULATION OF KIT SIGNALING 16 2.22e-01 1.76e-01 4.74e-01
PYROPTOSIS 21 1.62e-01 -1.76e-01 3.91e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 5.15e-02 1.76e-01 2.04e-01
ECM PROTEOGLYCANS 66 1.36e-02 1.76e-01 8.98e-02
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 2.96e-01 1.74e-01 5.61e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 20 1.78e-01 1.74e-01 4.13e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.46e-01 -1.73e-01 5.03e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 17 2.17e-01 -1.73e-01 4.72e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 153 2.35e-04 -1.72e-01 5.02e-03
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 2.82e-01 1.72e-01 5.50e-01
HIV INFECTION 224 9.25e-06 -1.72e-01 4.36e-04
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 20 1.83e-01 -1.72e-01 4.21e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.30e-01 1.72e-01 3.49e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 3.05e-01 1.71e-01 5.71e-01
PECAM1 INTERACTIONS 12 3.06e-01 1.71e-01 5.71e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 71 1.29e-02 1.71e-01 8.61e-02
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 1.57e-01 -1.70e-01 3.87e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 89 5.62e-03 -1.70e-01 4.91e-02
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 2.72e-01 1.70e-01 5.40e-01
SIGNALING BY THE B CELL RECEPTOR BCR 105 2.74e-03 -1.69e-01 2.84e-02
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 38 7.18e-02 1.69e-01 2.47e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 45 5.03e-02 1.69e-01 2.01e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 2.93e-01 -1.68e-01 5.60e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 1.13e-02 -1.68e-01 7.88e-02
RHOBTB1 GTPASE CYCLE 23 1.63e-01 -1.68e-01 3.92e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 13 2.96e-01 -1.67e-01 5.61e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 37 7.92e-02 -1.67e-01 2.58e-01
MAPK6 MAPK4 SIGNALING 86 7.70e-03 -1.66e-01 6.16e-02
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 54 3.48e-02 1.66e-01 1.56e-01
HEDGEHOG LIGAND BIOGENESIS 63 2.29e-02 -1.66e-01 1.22e-01
HSF1 ACTIVATION 26 1.44e-01 -1.66e-01 3.72e-01
HOMOLOGY DIRECTED REPAIR 106 3.28e-03 -1.65e-01 3.25e-02
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 122 1.79e-03 1.64e-01 2.07e-02
PEROXISOMAL LIPID METABOLISM 26 1.48e-01 -1.64e-01 3.77e-01
HDACS DEACETYLATE HISTONES 45 5.82e-02 1.63e-01 2.17e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS 69 1.93e-02 1.63e-01 1.11e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 3.30e-01 1.62e-01 5.94e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 43 6.58e-02 1.62e-01 2.37e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 60 3.04e-02 1.62e-01 1.49e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 2.38e-01 1.61e-01 4.94e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.49e-01 -1.60e-01 3.78e-01
TRNA PROCESSING IN THE NUCLEUS 56 3.85e-02 -1.60e-01 1.66e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 7.45e-02 -1.59e-01 2.52e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 6.84e-02 -1.59e-01 2.42e-01
NCAM1 INTERACTIONS 40 8.24e-02 1.59e-01 2.62e-01
GLYCOSAMINOGLYCAN METABOLISM 116 3.22e-03 1.58e-01 3.21e-02
TRANSCRIPTIONAL REGULATION BY MECP2 60 3.39e-02 1.58e-01 1.55e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 96 7.46e-03 1.58e-01 6.02e-02
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.88e-01 1.58e-01 6.44e-01
G ALPHA Q SIGNALLING EVENTS 161 5.70e-04 1.57e-01 8.99e-03
DAG AND IP3 SIGNALING 40 8.49e-02 1.57e-01 2.67e-01
METABOLISM OF FAT SOLUBLE VITAMINS 32 1.24e-01 1.57e-01 3.40e-01
SHC MEDIATED CASCADE FGFR1 16 2.78e-01 -1.57e-01 5.46e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 2.25e-01 1.57e-01 4.78e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 3.94e-01 1.56e-01 6.51e-01
NONHOMOLOGOUS END JOINING NHEJ 42 8.13e-02 -1.56e-01 2.60e-01
AMINE LIGAND BINDING RECEPTORS 28 1.55e-01 1.55e-01 3.85e-01
HEME BIOSYNTHESIS 13 3.32e-01 -1.55e-01 5.95e-01
TRANSCRIPTIONAL REGULATION BY E2F6 34 1.17e-01 -1.55e-01 3.26e-01
MITOCHONDRIAL BIOGENESIS 93 9.70e-03 -1.55e-01 7.12e-02
RAS PROCESSING 24 1.88e-01 -1.55e-01 4.29e-01
REGULATION OF BETA CELL DEVELOPMENT 29 1.49e-01 1.55e-01 3.77e-01
INTERFERON ALPHA BETA SIGNALING 57 4.32e-02 1.55e-01 1.79e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 13 3.34e-01 -1.55e-01 5.96e-01
METAL ION SLC TRANSPORTERS 25 1.81e-01 1.55e-01 4.18e-01
PROLONGED ERK ACTIVATION EVENTS 14 3.17e-01 -1.55e-01 5.83e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 87 1.28e-02 1.55e-01 8.61e-02
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 4.64e-02 1.54e-01 1.90e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 8.82e-02 1.54e-01 2.71e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 2.03e-01 -1.53e-01 4.52e-01
M PHASE 342 1.17e-06 -1.53e-01 8.22e-05
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 2.28e-02 1.53e-01 1.22e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 64 3.42e-02 -1.53e-01 1.56e-01
GPCR LIGAND BINDING 273 1.39e-05 1.53e-01 5.84e-04
SHC1 EVENTS IN ERBB4 SIGNALING 13 3.43e-01 -1.52e-01 6.02e-01
THE NLRP3 INFLAMMASOME 14 3.29e-01 -1.51e-01 5.94e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 3.47e-01 -1.51e-01 6.06e-01
RHOBTB2 GTPASE CYCLE 23 2.11e-01 -1.51e-01 4.61e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 22 2.22e-01 -1.50e-01 4.74e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.61e-01 1.50e-01 3.91e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 2.23e-01 -1.50e-01 4.75e-01
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 4.12e-01 1.50e-01 6.69e-01
RNA POLYMERASE I PROMOTER ESCAPE 46 7.95e-02 -1.49e-01 2.58e-01
CHROMATIN MODIFYING ENZYMES 219 1.41e-04 1.49e-01 3.62e-03
SIGNAL AMPLIFICATION 31 1.50e-01 1.49e-01 3.79e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 34 1.33e-01 -1.49e-01 3.50e-01
MATURATION OF NUCLEOPROTEIN 10 4.15e-01 -1.49e-01 6.72e-01
GAB1 SIGNALOSOME 14 3.36e-01 1.49e-01 5.97e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 1.90e-01 1.48e-01 4.31e-01
GAP JUNCTION ASSEMBLY 21 2.40e-01 -1.48e-01 4.98e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 2.53e-01 -1.48e-01 5.12e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 29 1.70e-01 1.47e-01 4.00e-01
ANTIGEN PROCESSING CROSS PRESENTATION 101 1.05e-02 -1.47e-01 7.54e-02
MITOTIC PROMETAPHASE 178 7.08e-04 -1.47e-01 1.01e-02
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 77 2.55e-02 -1.47e-01 1.30e-01
G PROTEIN MEDIATED EVENTS 52 6.65e-02 1.47e-01 2.38e-01
SIGNALING BY GPCR 490 2.78e-08 1.47e-01 3.77e-06
CLASS A 1 RHODOPSIN LIKE RECEPTORS 192 4.68e-04 1.47e-01 8.12e-03
NEDDYLATION 221 1.78e-04 -1.46e-01 4.04e-03
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 13 3.61e-01 1.46e-01 6.17e-01
FLT3 SIGNALING 36 1.29e-01 1.46e-01 3.49e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 2.97e-01 -1.46e-01 5.61e-01
ERK MAPK TARGETS 22 2.37e-01 -1.46e-01 4.93e-01
SIALIC ACID METABOLISM 32 1.54e-01 -1.46e-01 3.84e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 23 2.26e-01 1.46e-01 4.78e-01
TRANSCRIPTION OF THE HIV GENOME 67 3.98e-02 -1.45e-01 1.69e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 16 3.15e-01 -1.45e-01 5.81e-01
SYNTHESIS OF PE 13 3.68e-01 1.44e-01 6.26e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 20 2.64e-01 1.44e-01 5.27e-01
GROWTH HORMONE RECEPTOR SIGNALING 21 2.55e-01 1.44e-01 5.14e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 2.92e-01 -1.44e-01 5.59e-01
PEPTIDE LIGAND BINDING RECEPTORS 115 7.90e-03 1.43e-01 6.24e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 74 3.31e-02 1.43e-01 1.53e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 4.33e-01 1.43e-01 6.90e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 3.10e-02 -1.43e-01 1.50e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 24 2.27e-01 -1.43e-01 4.78e-01
TP53 REGULATES METABOLIC GENES 87 2.18e-02 -1.42e-01 1.22e-01
RHO GTPASES ACTIVATE FORMINS 120 7.13e-03 -1.42e-01 5.80e-02
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 1.71e-01 -1.42e-01 4.02e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 2.54e-02 -1.41e-01 1.30e-01
CYCLIN D ASSOCIATED EVENTS IN G1 45 1.02e-01 -1.41e-01 2.99e-01
INOSITOL PHOSPHATE METABOLISM 46 9.89e-02 1.41e-01 2.94e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 196 7.00e-04 1.41e-01 1.01e-02
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 90 2.13e-02 1.41e-01 1.20e-01
ADHERENS JUNCTIONS INTERACTIONS 30 1.83e-01 1.40e-01 4.21e-01
SPHINGOLIPID METABOLISM 79 3.19e-02 -1.40e-01 1.51e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 29 1.94e-01 -1.39e-01 4.37e-01
SIGNALING BY INSULIN RECEPTOR 64 5.41e-02 -1.39e-01 2.07e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 48 9.63e-02 1.39e-01 2.90e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 3.53e-01 -1.39e-01 6.08e-01
CELL CYCLE MITOTIC 476 2.59e-07 -1.38e-01 2.99e-05
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 3.11e-01 -1.38e-01 5.76e-01
INTERLEUKIN 10 SIGNALING 21 2.77e-01 1.37e-01 5.46e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 79 3.58e-02 -1.37e-01 1.60e-01
CHROMOSOME MAINTENANCE 101 1.78e-02 -1.37e-01 1.04e-01
RAF ACTIVATION 34 1.69e-01 -1.36e-01 3.99e-01
CELL CYCLE 594 1.65e-08 -1.36e-01 3.25e-06
DISEASES OF GLYCOSYLATION 126 8.46e-03 1.36e-01 6.50e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 3.97e-01 1.36e-01 6.55e-01
RHO GTPASES ACTIVATE KTN1 11 4.35e-01 -1.36e-01 6.91e-01
MITOPHAGY 29 2.06e-01 -1.36e-01 4.55e-01
ANTIMICROBIAL PEPTIDES 17 3.33e-01 -1.36e-01 5.95e-01
FATTY ACYL COA BIOSYNTHESIS 32 1.84e-01 -1.36e-01 4.22e-01
INTERLEUKIN 1 SIGNALING 98 2.05e-02 -1.35e-01 1.17e-01
TRNA PROCESSING 105 1.70e-02 -1.35e-01 1.02e-01
SENSORY PROCESSING OF SOUND 61 6.90e-02 1.35e-01 2.44e-01
FLT3 SIGNALING IN DISEASE 28 2.19e-01 1.34e-01 4.74e-01
RAC1 GTPASE CYCLE 180 1.97e-03 1.34e-01 2.21e-02
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 53 9.32e-02 -1.33e-01 2.83e-01
KINESINS 48 1.10e-01 1.33e-01 3.16e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 83 3.62e-02 -1.33e-01 1.61e-01
DNA DAMAGE BYPASS 45 1.23e-01 -1.33e-01 3.38e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 7.03e-02 -1.33e-01 2.44e-01
VISUAL PHOTOTRANSDUCTION 59 7.75e-02 1.33e-01 2.56e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 1.68e-01 -1.33e-01 3.98e-01
PKMTS METHYLATE HISTONE LYSINES 47 1.15e-01 1.33e-01 3.24e-01
MHC CLASS II ANTIGEN PRESENTATION 102 2.07e-02 -1.33e-01 1.17e-01
PEROXISOMAL PROTEIN IMPORT 58 8.11e-02 -1.32e-01 2.60e-01
HIV LIFE CYCLE 142 6.49e-03 -1.32e-01 5.39e-02
ATTENUATION PHASE 24 2.62e-01 -1.32e-01 5.24e-01
G ALPHA Z SIGNALLING EVENTS 44 1.29e-01 1.32e-01 3.49e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 8.13e-02 -1.31e-01 2.60e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 4.51e-01 -1.31e-01 7.06e-01
ONCOGENIC MAPK SIGNALING 76 4.87e-02 1.31e-01 1.96e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 64 7.07e-02 -1.31e-01 2.44e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 4.55e-01 -1.30e-01 7.08e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 86 3.73e-02 -1.30e-01 1.63e-01
SYNTHESIS OF PA 29 2.26e-01 1.30e-01 4.78e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 3.28e-01 1.30e-01 5.94e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 3.70e-01 -1.29e-01 6.29e-01
TRANSLESION SYNTHESIS BY POLH 19 3.31e-01 -1.29e-01 5.94e-01
EFFECTS OF PIP2 HYDROLYSIS 27 2.46e-01 1.29e-01 5.03e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 23 2.85e-01 -1.29e-01 5.53e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 4.02e-02 -1.29e-01 1.71e-01
ACYL CHAIN REMODELLING OF PG 10 4.82e-01 -1.28e-01 7.34e-01
SIGNALING BY EGFR 47 1.30e-01 1.28e-01 3.49e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 4.64e-01 1.27e-01 7.17e-01
FRS MEDIATED FGFR1 SIGNALING 18 3.50e-01 -1.27e-01 6.08e-01
RHO GTPASES ACTIVATE IQGAPS 24 2.81e-01 -1.27e-01 5.50e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 3.56e-01 1.26e-01 6.10e-01
GLUCONEOGENESIS 27 2.59e-01 -1.25e-01 5.21e-01
ABC TRANSPORTER DISORDERS 71 6.76e-02 -1.25e-01 2.40e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 2.88e-01 -1.25e-01 5.55e-01
DUAL INCISION IN TC NER 64 8.43e-02 -1.25e-01 2.66e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 37 1.91e-01 1.24e-01 4.32e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 4.39e-01 -1.24e-01 6.94e-01
IRS MEDIATED SIGNALLING 40 1.78e-01 -1.23e-01 4.13e-01
MTORC1 MEDIATED SIGNALLING 24 2.97e-01 -1.23e-01 5.61e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 4.43e-01 1.23e-01 6.99e-01
AURKA ACTIVATION BY TPX2 72 7.23e-02 -1.23e-01 2.48e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 3.82e-01 -1.22e-01 6.39e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 245 1.00e-03 1.22e-01 1.34e-02
SIGNALING BY BMP 25 2.91e-01 1.22e-01 5.59e-01
DNA DOUBLE STRAND BREAK REPAIR 135 1.49e-02 -1.21e-01 9.51e-02
NEURONAL SYSTEM 373 5.94e-05 1.21e-01 1.89e-03
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 31 2.43e-01 1.21e-01 5.00e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 9.42e-02 -1.21e-01 2.85e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 1.06e-01 1.21e-01 3.09e-01
FATTY ACID METABOLISM 147 1.16e-02 -1.21e-01 8.01e-02
OTHER INTERLEUKIN SIGNALING 20 3.51e-01 1.20e-01 6.08e-01
PI 3K CASCADE FGFR1 16 4.05e-01 -1.20e-01 6.63e-01
ERKS ARE INACTIVATED 13 4.53e-01 -1.20e-01 7.06e-01
SENSORY PERCEPTION 149 1.15e-02 1.20e-01 8.01e-02
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 109 3.06e-02 1.20e-01 1.49e-01
PROGRAMMED CELL DEATH 189 4.70e-03 -1.19e-01 4.29e-02
NETRIN 1 SIGNALING 50 1.45e-01 1.19e-01 3.72e-01
SYNDECAN INTERACTIONS 26 2.93e-01 1.19e-01 5.60e-01
SIGNALING BY ERYTHROPOIETIN 24 3.14e-01 1.19e-01 5.79e-01
REGULATED NECROSIS 46 1.63e-01 -1.19e-01 3.92e-01
DEATH RECEPTOR SIGNALLING 134 1.77e-02 1.19e-01 1.04e-01
HYALURONAN UPTAKE AND DEGRADATION 11 4.95e-01 1.19e-01 7.44e-01
NUCLEOTIDE EXCISION REPAIR 109 3.28e-02 -1.18e-01 1.53e-01
KERATAN SULFATE BIOSYNTHESIS 25 3.09e-01 1.17e-01 5.75e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 291 5.84e-04 -1.17e-01 9.06e-03
GRB2 EVENTS IN ERBB2 SIGNALING 15 4.32e-01 -1.17e-01 6.89e-01
GLYCOGEN SYNTHESIS 14 4.48e-01 -1.17e-01 7.05e-01
MRNA SPLICING MINOR PATHWAY 52 1.45e-01 -1.17e-01 3.72e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 29 2.76e-01 1.17e-01 5.46e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 107 3.71e-02 1.17e-01 1.63e-01
L1CAM INTERACTIONS 107 3.76e-02 1.16e-01 1.64e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 2.49e-01 -1.16e-01 5.06e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 34 2.43e-01 -1.16e-01 5.00e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 19 3.84e-01 -1.15e-01 6.41e-01
PREGNENOLONE BIOSYNTHESIS 12 4.91e-01 -1.15e-01 7.41e-01
KERATAN SULFATE KERATIN METABOLISM 31 2.69e-01 1.15e-01 5.36e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 1.11e-01 -1.14e-01 3.18e-01
PYRIMIDINE SALVAGE 10 5.32e-01 1.14e-01 7.71e-01
SIGNALING BY NODAL 15 4.45e-01 1.14e-01 7.02e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 30 2.82e-01 -1.14e-01 5.50e-01
RAP1 SIGNALLING 15 4.49e-01 -1.13e-01 7.05e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 4.52e-01 -1.12e-01 7.06e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 56 1.47e-01 1.12e-01 3.74e-01
TNFR2 NON CANONICAL NF KB PATHWAY 84 7.58e-02 -1.12e-01 2.54e-01
UCH PROTEINASES 91 6.60e-02 -1.12e-01 2.37e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 4.87e-01 -1.11e-01 7.38e-01
MET ACTIVATES PTK2 SIGNALING 28 3.08e-01 1.11e-01 5.74e-01
G ALPHA I SIGNALLING EVENTS 206 6.03e-03 1.11e-01 5.19e-02
DEADENYLATION DEPENDENT MRNA DECAY 55 1.55e-01 -1.11e-01 3.85e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 3.47e-01 1.11e-01 6.06e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 55 1.59e-01 -1.10e-01 3.88e-01
APOPTOSIS 167 1.44e-02 -1.10e-01 9.26e-02
SIGNALING BY NTRK2 TRKB 24 3.53e-01 1.09e-01 6.08e-01
SEMAPHORIN INTERACTIONS 64 1.32e-01 1.09e-01 3.49e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT 96 6.56e-02 -1.09e-01 2.37e-01
KERATAN SULFATE DEGRADATION 12 5.15e-01 1.09e-01 7.60e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 2.74e-01 1.08e-01 5.43e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 5.34e-01 -1.08e-01 7.73e-01
MTOR SIGNALLING 41 2.30e-01 -1.08e-01 4.81e-01
MAP2K AND MAPK ACTIVATION 36 2.61e-01 1.08e-01 5.24e-01
PROLACTIN RECEPTOR SIGNALING 12 5.17e-01 1.08e-01 7.60e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 354 4.99e-04 -1.08e-01 8.53e-03
EXTRACELLULAR MATRIX ORGANIZATION 247 3.54e-03 1.08e-01 3.42e-02
GABA RECEPTOR ACTIVATION 55 1.67e-01 1.08e-01 3.98e-01
AQUAPORIN MEDIATED TRANSPORT 42 2.27e-01 1.08e-01 4.78e-01
CONDENSATION OF PROPHASE CHROMOSOMES 27 3.36e-01 -1.07e-01 5.97e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 4.07e-01 1.07e-01 6.65e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 3.36e-01 -1.07e-01 5.97e-01
PLATELET AGGREGATION PLUG FORMATION 32 2.96e-01 1.07e-01 5.61e-01
DAP12 SIGNALING 24 3.66e-01 1.07e-01 6.25e-01
LAGGING STRAND SYNTHESIS 20 4.10e-01 -1.07e-01 6.67e-01
RNA POLYMERASE III CHAIN ELONGATION 18 4.35e-01 -1.06e-01 6.91e-01
METABOLISM OF COFACTORS 19 4.23e-01 -1.06e-01 6.81e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 5.24e-01 -1.06e-01 7.66e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 1.15e-01 -1.06e-01 3.24e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 3.26e-01 -1.05e-01 5.92e-01
FORMATION OF THE CORNIFIED ENVELOPE 26 3.53e-01 1.05e-01 6.08e-01
KERATINIZATION 26 3.53e-01 1.05e-01 6.08e-01
TELOMERE MAINTENANCE 77 1.13e-01 -1.05e-01 3.21e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 2.73e-01 -1.04e-01 5.41e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 28 3.42e-01 1.04e-01 6.02e-01
METABOLISM OF RNA 647 7.67e-06 -1.03e-01 3.93e-04
KILLING MECHANISMS 11 5.54e-01 1.03e-01 7.89e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.50e-01 -1.03e-01 7.06e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 13 5.22e-01 1.03e-01 7.64e-01
INTERLEUKIN 1 FAMILY SIGNALING 124 4.89e-02 -1.02e-01 1.96e-01
FCERI MEDIATED MAPK ACTIVATION 28 3.50e-01 -1.02e-01 6.08e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 4.95e-01 -1.02e-01 7.44e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 112 6.28e-02 -1.02e-01 2.29e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 2.62e-01 -1.01e-01 5.24e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 5.62e-01 -1.01e-01 7.95e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 5.14e-01 -1.01e-01 7.60e-01
CA DEPENDENT EVENTS 36 2.97e-01 1.01e-01 5.61e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 3.75e-01 -1.01e-01 6.34e-01
PCP CE PATHWAY 91 9.78e-02 -1.00e-01 2.92e-01
BIOLOGICAL OXIDATIONS 125 5.34e-02 -1.00e-01 2.07e-01
CELLULAR RESPONSE TO HEAT STRESS 95 9.57e-02 -9.90e-02 2.89e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 4.11e-01 -9.89e-02 6.69e-01
CD28 CO STIMULATION 31 3.42e-01 -9.87e-02 6.02e-01
INTERLEUKIN 17 SIGNALING 68 1.60e-01 -9.87e-02 3.88e-01
TOLL LIKE RECEPTOR CASCADES 141 4.35e-02 -9.86e-02 1.80e-01
JOSEPHIN DOMAIN DUBS 11 5.73e-01 -9.82e-02 8.01e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 4.08e-01 -9.76e-02 6.65e-01
PURINE CATABOLISM 16 5.00e-01 -9.73e-02 7.50e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 6.68e-02 9.69e-02 2.39e-01
NICOTINATE METABOLISM 25 4.02e-01 -9.69e-02 6.61e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 4.77e-01 9.68e-02 7.32e-01
RHO GTPASE CYCLE 427 6.50e-04 9.65e-02 9.82e-03
RHOBTB GTPASE CYCLE 35 3.24e-01 -9.64e-02 5.89e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 17 4.95e-01 9.57e-02 7.44e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.08e-01 -9.56e-02 7.57e-01
TRANS GOLGI NETWORK VESICLE BUDDING 70 1.67e-01 -9.55e-02 3.98e-01
DAP12 INTERACTIONS 31 3.57e-01 9.55e-02 6.13e-01
PURINE SALVAGE 12 5.69e-01 -9.50e-02 8.00e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 92 1.16e-01 -9.50e-02 3.24e-01
ANCHORING FIBRIL FORMATION 14 5.41e-01 -9.44e-02 7.78e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 3.35e-01 9.42e-02 5.97e-01
O LINKED GLYCOSYLATION 87 1.31e-01 9.36e-02 3.49e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 87 1.34e-01 -9.29e-02 3.52e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 95 1.18e-01 9.28e-02 3.28e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 6.12e-01 9.27e-02 8.25e-01
COLLAGEN DEGRADATION 51 2.53e-01 -9.26e-02 5.12e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 5.49e-01 -9.26e-02 7.84e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 3.24e-01 -9.26e-02 5.89e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 5.80e-01 -9.23e-02 8.05e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 5.98e-01 -9.19e-02 8.17e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 3.77e-01 9.17e-02 6.35e-01
VOLTAGE GATED POTASSIUM CHANNELS 39 3.22e-01 9.17e-02 5.88e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 61 2.16e-01 -9.16e-02 4.71e-01
CELL CELL COMMUNICATION 107 1.02e-01 9.16e-02 2.99e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 64 2.06e-01 -9.14e-02 4.55e-01
INTERLEUKIN 27 SIGNALING 10 6.17e-01 9.13e-02 8.31e-01
COSTIMULATION BY THE CD28 FAMILY 51 2.61e-01 -9.11e-02 5.23e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 4.70e-01 -9.10e-02 7.23e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 2.29e-01 -9.05e-02 4.81e-01
SIGNALLING TO RAS 20 4.84e-01 9.05e-02 7.35e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 4.63e-01 -9.03e-02 7.16e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 3.70e-01 -9.01e-02 6.29e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 5.46e-01 -9.01e-02 7.82e-01
LYSOSOME VESICLE BIOGENESIS 33 3.75e-01 -8.92e-02 6.34e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 4.32e-01 8.91e-02 6.89e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS 166 4.80e-02 -8.90e-02 1.94e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 5.51e-01 8.89e-02 7.86e-01
THE PHOTOTRANSDUCTION CASCADE 21 4.81e-01 8.89e-02 7.34e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 5.65e-01 -8.88e-02 7.97e-01
UNFOLDED PROTEIN RESPONSE UPR 85 1.57e-01 8.88e-02 3.87e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 19 5.03e-01 8.87e-02 7.52e-01
METABOLISM OF FOLATE AND PTERINES 15 5.52e-01 -8.87e-02 7.86e-01
PLASMA LIPOPROTEIN CLEARANCE 27 4.26e-01 8.86e-02 6.84e-01
HS GAG BIOSYNTHESIS 30 4.03e-01 8.82e-02 6.62e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 6.30e-01 -8.81e-02 8.31e-01
SLC TRANSPORTER DISORDERS 78 1.79e-01 8.80e-02 4.16e-01
EXTENSION OF TELOMERES 49 2.88e-01 -8.78e-02 5.55e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 3.20e-01 -8.77e-02 5.86e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 604 2.45e-04 -8.77e-02 5.02e-03
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 14 5.71e-01 -8.75e-02 8.00e-01
OLFACTORY SIGNALING PATHWAY 31 4.00e-01 8.74e-02 6.59e-01
OPIOID SIGNALLING 87 1.59e-01 8.74e-02 3.88e-01
HIV TRANSCRIPTION ELONGATION 42 3.32e-01 -8.65e-02 5.95e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 5.04e-01 8.62e-02 7.53e-01
DNA REPAIR 289 1.18e-02 -8.62e-02 8.09e-02
FERTILIZATION 13 5.91e-01 8.61e-02 8.13e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 5.92e-01 -8.59e-02 8.13e-01
PHOSPHOLIPID METABOLISM 187 4.31e-02 8.58e-02 1.79e-01
MYOGENESIS 25 4.58e-01 8.58e-02 7.09e-01
AMINO ACIDS REGULATE MTORC1 51 2.90e-01 -8.57e-02 5.58e-01
SIGNALING BY NOTCH4 83 1.78e-01 -8.56e-02 4.13e-01
DNA STRAND ELONGATION 32 4.02e-01 -8.56e-02 6.61e-01
TRANSCRIPTIONAL REGULATION BY TP53 347 6.41e-03 -8.53e-02 5.39e-02
MEIOTIC RECOMBINATION 36 3.76e-01 -8.52e-02 6.35e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 26 4.52e-01 8.51e-02 7.06e-01
ADAPTIVE IMMUNE SYSTEM 617 3.22e-04 -8.51e-02 6.32e-03
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 3.04e-01 -8.49e-02 5.70e-01
DISEASES OF METABOLISM 200 3.92e-02 8.47e-02 1.68e-01
INSULIN RECEPTOR SIGNALLING CASCADE 45 3.29e-01 -8.40e-02 5.94e-01
GENERATION OF SECOND MESSENGER MOLECULES 20 5.16e-01 -8.38e-02 7.60e-01
PLATELET HOMEOSTASIS 77 2.04e-01 8.37e-02 4.54e-01
TRNA AMINOACYLATION 42 3.48e-01 -8.37e-02 6.07e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 6.32e-01 8.34e-02 8.32e-01
DNA DAMAGE RECOGNITION IN GG NER 38 3.75e-01 -8.32e-02 6.34e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 13 6.04e-01 -8.30e-02 8.23e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 6.50e-01 -8.30e-02 8.41e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 183 5.32e-02 8.29e-02 2.07e-01
MRNA SPLICING 188 5.06e-02 -8.28e-02 2.02e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 3.60e-01 8.26e-02 6.16e-01
ZINC TRANSPORTERS 16 5.71e-01 8.19e-02 8.00e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 5.37e-01 -8.18e-02 7.75e-01
METABOLISM OF NUCLEOTIDES 92 1.75e-01 -8.18e-02 4.10e-01
RHO GTPASE EFFECTORS 252 2.57e-02 -8.17e-02 1.30e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 6.10e-01 8.17e-02 8.25e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 4.98e-01 8.16e-02 7.47e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 5.28e-01 8.15e-02 7.69e-01
FGFR2 ALTERNATIVE SPLICING 25 4.80e-01 -8.15e-02 7.34e-01
CTLA4 INHIBITORY SIGNALING 20 5.28e-01 -8.15e-02 7.69e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 2.86e-01 -8.10e-02 5.54e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 46 3.42e-01 -8.10e-02 6.02e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 46 3.43e-01 -8.09e-02 6.02e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 3.19e-01 8.07e-02 5.84e-01
CIRCADIAN CLOCK 68 2.51e-01 8.04e-02 5.10e-01
TRP CHANNELS 20 5.35e-01 8.01e-02 7.74e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 24 5.02e-01 -7.92e-02 7.51e-01
SELECTIVE AUTOPHAGY 73 2.43e-01 -7.90e-02 5.00e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 37 4.06e-01 -7.89e-02 6.64e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 5.98e-01 -7.86e-02 8.17e-01
LEISHMANIA INFECTION 201 5.51e-02 7.86e-02 2.08e-01
MYD88 INDEPENDENT TLR4 CASCADE 94 1.90e-01 -7.83e-02 4.31e-01
DSCAM INTERACTIONS 11 6.53e-01 -7.83e-02 8.42e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 95 1.88e-01 -7.83e-02 4.28e-01
POLYMERASE SWITCHING 14 6.12e-01 -7.82e-02 8.25e-01
INFLAMMASOMES 18 5.66e-01 -7.82e-02 7.97e-01
NUCLEAR SIGNALING BY ERBB4 31 4.52e-01 7.80e-02 7.06e-01
EUKARYOTIC TRANSLATION INITIATION 115 1.49e-01 -7.80e-02 3.77e-01
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 5.78e-01 7.80e-02 8.03e-01
SIGNALING BY FGFR2 64 2.82e-01 -7.78e-02 5.50e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 93 1.95e-01 7.78e-02 4.38e-01
COPII MEDIATED VESICLE TRANSPORT 66 2.75e-01 -7.77e-02 5.45e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 55 3.21e-01 7.73e-02 5.87e-01
DISEASES OF PROGRAMMED CELL DEATH 53 3.31e-01 -7.73e-02 5.94e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 4.07e-02 -7.73e-02 1.72e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 36 4.23e-01 -7.73e-02 6.81e-01
SIGNALING BY NOTCH 187 6.95e-02 7.70e-02 2.44e-01
RRNA PROCESSING 195 6.42e-02 -7.70e-02 2.33e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 6.19e-01 -7.68e-02 8.31e-01
POTASSIUM CHANNELS 91 2.06e-01 7.67e-02 4.55e-01
RHO GTPASES ACTIVATE CIT 18 5.76e-01 7.62e-02 8.02e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 36 4.30e-01 -7.60e-02 6.89e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 6.23e-01 7.59e-02 8.31e-01
COMPLEMENT CASCADE 28 4.89e-01 7.55e-02 7.40e-01
ACYL CHAIN REMODELLING OF PS 14 6.25e-01 -7.54e-02 8.31e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 3.49e-01 -7.51e-02 6.08e-01
PLATELET CALCIUM HOMEOSTASIS 25 5.16e-01 7.51e-02 7.60e-01
SODIUM CALCIUM EXCHANGERS 10 6.82e-01 7.48e-02 8.57e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 4.78e-01 -7.48e-02 7.32e-01
INITIAL TRIGGERING OF COMPLEMENT 13 6.41e-01 7.48e-02 8.38e-01
LYSINE CATABOLISM 11 6.69e-01 -7.45e-02 8.50e-01
ION CHANNEL TRANSPORT 142 1.26e-01 7.44e-02 3.44e-01
SARS COV 1 INFECTION 48 3.73e-01 -7.43e-02 6.33e-01
CHAPERONE MEDIATED AUTOPHAGY 21 5.56e-01 -7.43e-02 7.89e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES 321 2.24e-02 -7.43e-02 1.22e-01
RHO GTPASES ACTIVATE PKNS 46 3.86e-01 -7.40e-02 6.41e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 6.57e-01 -7.40e-02 8.44e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 16 6.09e-01 7.38e-02 8.25e-01
ASSEMBLY OF THE HIV VIRION 16 6.10e-01 -7.36e-02 8.25e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 4.66e-01 -7.33e-02 7.18e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 5.10e-01 -7.33e-02 7.57e-01
SIGNALING BY RETINOIC ACID 34 4.60e-01 -7.32e-02 7.12e-01
AUTOPHAGY 140 1.35e-01 -7.32e-02 3.53e-01
SIGNALING BY SCF KIT 41 4.18e-01 7.32e-02 6.75e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 3.82e-01 -7.29e-02 6.39e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 24 5.37e-01 -7.29e-02 7.75e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 6.51e-01 -7.25e-02 8.41e-01
DUAL INCISION IN GG NER 40 4.29e-01 -7.24e-02 6.87e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 5.88e-01 7.19e-02 8.11e-01
HATS ACETYLATE HISTONES 92 2.34e-01 7.19e-02 4.88e-01
DISEASES OF IMMUNE SYSTEM 27 5.19e-01 -7.17e-02 7.62e-01
FOXO MEDIATED TRANSCRIPTION 59 3.43e-01 7.14e-02 6.02e-01
SIGNALING BY FGFR IN DISEASE 57 3.53e-01 -7.12e-02 6.08e-01
PROTEIN FOLDING 90 2.44e-01 -7.11e-02 5.01e-01
DEVELOPMENTAL BIOLOGY 830 5.66e-04 7.08e-02 8.99e-03
SNRNP ASSEMBLY 51 3.83e-01 -7.07e-02 6.39e-01
UB SPECIFIC PROCESSING PROTEASES 170 1.12e-01 -7.07e-02 3.20e-01
SHC1 EVENTS IN EGFR SIGNALING 11 6.86e-01 -7.05e-02 8.59e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 16 6.26e-01 -7.04e-02 8.31e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 5.43e-01 -7.02e-02 7.80e-01
HSF1 DEPENDENT TRANSACTIVATION 34 4.79e-01 -7.01e-02 7.33e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 4.93e-01 -7.00e-02 7.43e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 6.75e-01 7.00e-02 8.52e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 5.15e-01 6.99e-02 7.60e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 5.38e-01 6.98e-02 7.76e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 74 3.03e-01 -6.93e-02 5.69e-01
MITOTIC PROPHASE 93 2.48e-01 -6.93e-02 5.06e-01
DEADENYLATION OF MRNA 25 5.49e-01 -6.92e-02 7.84e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 5.83e-01 6.92e-02 8.08e-01
STIMULI SENSING CHANNELS 76 2.97e-01 6.92e-02 5.61e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 6.55e-01 -6.89e-02 8.44e-01
NEGATIVE REGULATION OF FLT3 14 6.56e-01 6.88e-02 8.44e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 3.15e-01 -6.81e-02 5.81e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 5.57e-01 -6.79e-02 7.90e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 79 2.98e-01 6.77e-02 5.62e-01
REGULATION OF SIGNALING BY CBL 22 5.84e-01 6.75e-02 8.08e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 7.00e-01 -6.72e-02 8.64e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 18 6.22e-01 -6.70e-02 8.31e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 5.98e-01 6.65e-02 8.17e-01
ERBB2 REGULATES CELL MOTILITY 14 6.67e-01 -6.64e-02 8.49e-01
DEUBIQUITINATION 244 7.69e-02 -6.58e-02 2.55e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 7.19e-01 6.57e-02 8.77e-01
RHO GTPASES ACTIVATE ROCKS 19 6.21e-01 -6.55e-02 8.31e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 6.62e-01 -6.51e-02 8.48e-01
SIGNALING BY ERBB2 48 4.37e-01 -6.48e-02 6.92e-01
EPHB MEDIATED FORWARD SIGNALING 42 4.68e-01 -6.48e-02 7.20e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 6.64e-01 -6.47e-02 8.49e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 6.08e-01 -6.47e-02 8.25e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 6.66e-01 -6.44e-02 8.49e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 6.02e-01 -6.42e-02 8.21e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 5.59e-01 -6.39e-02 7.92e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 6.90e-01 -6.38e-02 8.61e-01
REGULATION OF FZD BY UBIQUITINATION 19 6.33e-01 6.33e-02 8.32e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 96 2.85e-01 -6.32e-02 5.53e-01
ARACHIDONIC ACID METABOLISM 40 4.89e-01 -6.32e-02 7.40e-01
TRANSCRIPTIONAL REGULATION BY RUNX1 180 1.45e-01 6.31e-02 3.72e-01
SIGNALING BY FGFR1 IN DISEASE 33 5.31e-01 6.30e-02 7.71e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 286 6.74e-02 -6.30e-02 2.40e-01
RESOLUTION OF ABASIC SITES AP SITES 37 5.09e-01 -6.28e-02 7.57e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 6.20e-01 -6.25e-02 8.31e-01
POLO LIKE KINASE MEDIATED EVENTS 13 6.98e-01 -6.23e-02 8.63e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 6.06e-01 6.22e-02 8.24e-01
RNA POLYMERASE II TRANSCRIPTION 1102 5.41e-04 -6.22e-02 8.99e-03
HCMV LATE EVENTS 64 3.90e-01 -6.21e-02 6.47e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 5.84e-01 -6.20e-02 8.08e-01
TRIGLYCERIDE CATABOLISM 14 6.89e-01 -6.19e-02 8.60e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 62 4.04e-01 -6.13e-02 6.63e-01
HEMOSTASIS 475 2.29e-02 6.11e-02 1.22e-01
ACYL CHAIN REMODELLING OF PC 17 6.66e-01 6.05e-02 8.49e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 6.76e-01 -6.04e-02 8.52e-01
MET PROMOTES CELL MOTILITY 38 5.22e-01 6.01e-02 7.64e-01
INTERFERON GAMMA SIGNALING 80 3.54e-01 6.00e-02 6.08e-01
NICOTINAMIDE SALVAGING 15 6.88e-01 -6.00e-02 8.60e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 6.35e-01 5.98e-02 8.33e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 142 2.19e-01 -5.98e-02 4.74e-01
SIGNALING BY ERBB4 57 4.36e-01 5.96e-02 6.92e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 15 6.90e-01 5.96e-02 8.60e-01
METABOLISM OF CARBOHYDRATES 262 9.75e-02 5.96e-02 2.92e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 3.78e-01 -5.93e-02 6.35e-01
LAMININ INTERACTIONS 28 5.88e-01 5.92e-02 8.11e-01
CGMP EFFECTS 15 6.92e-01 5.91e-02 8.61e-01
CARDIAC CONDUCTION 109 2.88e-01 5.89e-02 5.56e-01
RHOJ GTPASE CYCLE 55 4.53e-01 5.85e-02 7.06e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 5.93e-01 -5.84e-02 8.14e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 7.16e-01 5.82e-02 8.76e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 7.27e-01 5.81e-02 8.81e-01
POTENTIAL THERAPEUTICS FOR SARS 77 3.81e-01 5.78e-02 6.39e-01
RHOD GTPASE CYCLE 51 4.77e-01 5.75e-02 7.32e-01
SIGNALING BY FGFR1 44 5.11e-01 -5.73e-02 7.58e-01
O LINKED GLYCOSYLATION OF MUCINS 40 5.31e-01 5.73e-02 7.71e-01
BASIGIN INTERACTIONS 22 6.43e-01 5.70e-02 8.40e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 6.44e-01 -5.69e-02 8.40e-01
INFLUENZA INFECTION 146 2.41e-01 -5.63e-02 4.98e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 7.07e-01 5.62e-02 8.70e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 7.39e-01 -5.56e-02 8.83e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 5.71e-01 5.54e-02 8.00e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 7.51e-01 -5.53e-02 8.89e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 6.76e-01 -5.53e-02 8.52e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 6.26e-01 -5.53e-02 8.31e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 5.72e-01 -5.53e-02 8.00e-01
TIE2 SIGNALING 17 6.94e-01 -5.52e-02 8.61e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 6.69e-01 5.51e-02 8.50e-01
INNATE IMMUNE SYSTEM 794 8.62e-03 -5.51e-02 6.56e-02
IRAK1 RECRUITS IKK COMPLEX 14 7.22e-01 5.49e-02 8.78e-01
AGGREPHAGY 35 5.76e-01 -5.46e-02 8.02e-01
ESTROGEN DEPENDENT GENE EXPRESSION 102 3.42e-01 5.45e-02 6.02e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 6.98e-01 5.43e-02 8.63e-01
ACTIVATION OF RAC1 13 7.35e-01 -5.42e-02 8.83e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 7.35e-01 5.41e-02 8.83e-01
G BETA GAMMA SIGNALLING THROUGH CDC42 19 6.83e-01 -5.41e-02 8.58e-01
NERVOUS SYSTEM DEVELOPMENT 554 3.00e-02 5.41e-02 1.47e-01
HEDGEHOG ON STATE 84 3.92e-01 -5.40e-02 6.50e-01
VITAMIN B5 PANTOTHENATE METABOLISM 15 7.17e-01 -5.40e-02 8.76e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 6.70e-01 -5.36e-02 8.50e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1226 2.04e-03 -5.28e-02 2.25e-02
COPI MEDIATED ANTEROGRADE TRANSPORT 91 3.85e-01 -5.27e-02 6.41e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 28 6.29e-01 -5.27e-02 8.31e-01
SIGNALING BY MET 74 4.33e-01 5.27e-02 6.90e-01
SIGNALING BY FGFR 75 4.31e-01 -5.26e-02 6.89e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 7.43e-01 5.25e-02 8.83e-01
P75NTR SIGNALS VIA NF KB 16 7.17e-01 5.24e-02 8.76e-01
GLYCOGEN STORAGE DISEASES 12 7.54e-01 5.23e-02 8.91e-01
NEUTROPHIL DEGRANULATION 394 7.55e-02 -5.23e-02 2.54e-01
TRIGLYCERIDE METABOLISM 24 6.59e-01 -5.21e-02 8.45e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 6.23e-01 -5.18e-02 8.31e-01
PI 3K CASCADE FGFR4 12 7.56e-01 5.18e-02 8.91e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 7.38e-01 5.16e-02 8.83e-01
MICRORNA MIRNA BIOGENESIS 24 6.62e-01 5.16e-02 8.48e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 7.21e-01 5.15e-02 8.78e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 7.34e-01 5.07e-02 8.83e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 63 4.86e-01 -5.07e-02 7.38e-01
UNWINDING OF DNA 12 7.62e-01 -5.06e-02 8.92e-01
BASE EXCISION REPAIR 55 5.17e-01 -5.05e-02 7.60e-01
NUCLEOBASE BIOSYNTHESIS 15 7.35e-01 -5.04e-02 8.83e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 5.65e-01 5.01e-02 7.97e-01
SIGNALING BY PDGFR IN DISEASE 20 6.98e-01 5.01e-02 8.63e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 42 5.75e-01 -5.00e-02 8.02e-01
PTEN REGULATION 138 3.12e-01 -4.99e-02 5.77e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 105 3.80e-01 4.96e-02 6.38e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 15 7.40e-01 4.96e-02 8.83e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 25 6.71e-01 -4.90e-02 8.50e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 5.09e-01 -4.90e-02 7.57e-01
CELLULAR RESPONSE TO STARVATION 147 3.10e-01 -4.86e-02 5.75e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 7.82e-01 -4.83e-02 8.99e-01
ION HOMEOSTASIS 49 5.60e-01 4.81e-02 7.93e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 7.74e-01 -4.79e-02 8.97e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 6.45e-01 -4.78e-02 8.40e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 6.30e-01 -4.78e-02 8.31e-01
ENOS ACTIVATION 11 7.87e-01 -4.71e-02 9.03e-01
VIRAL MESSENGER RNA SYNTHESIS 42 5.98e-01 -4.70e-02 8.17e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 222 2.29e-01 4.69e-02 4.81e-01
SIGNALING BY ROBO RECEPTORS 211 2.44e-01 -4.66e-02 5.01e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 7.40e-01 -4.65e-02 8.83e-01
MUSCLE CONTRACTION 164 3.07e-01 4.62e-02 5.73e-01
OXIDATIVE STRESS INDUCED SENESCENCE 77 4.83e-01 4.62e-02 7.35e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 5.23e-01 4.62e-02 7.65e-01
SIGNALING BY HEDGEHOG 143 3.42e-01 4.60e-02 6.02e-01
REDUCTION OF CYTOSOLIC CA LEVELS 11 7.94e-01 -4.55e-02 9.08e-01
RAC3 GTPASE CYCLE 91 4.56e-01 4.53e-02 7.08e-01
CALNEXIN CALRETICULIN CYCLE 26 6.93e-01 4.47e-02 8.61e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 6.12e-01 4.47e-02 8.25e-01
REGULATION OF TP53 ACTIVITY 155 3.40e-01 -4.45e-02 6.02e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 7.58e-01 4.44e-02 8.91e-01
INWARDLY RECTIFYING K CHANNELS 32 6.66e-01 4.41e-02 8.49e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 7.92e-01 -4.40e-02 9.06e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 8.00e-01 -4.40e-02 9.11e-01
RAB REGULATION OF TRAFFICKING 118 4.13e-01 -4.36e-02 6.69e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 24 7.11e-01 4.36e-02 8.74e-01
PI 3K CASCADE FGFR3 13 7.86e-01 4.36e-02 9.03e-01
ASPARAGINE N LINKED GLYCOSYLATION 285 2.12e-01 -4.30e-02 4.63e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 6.89e-01 4.30e-02 8.60e-01
FANCONI ANEMIA PATHWAY 36 6.57e-01 -4.28e-02 8.44e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 68 5.47e-01 -4.23e-02 7.82e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 7.50e-01 4.22e-02 8.89e-01
SIGNALING BY NUCLEAR RECEPTORS 224 2.81e-01 4.18e-02 5.50e-01
SIGNALING BY NTRKS 130 4.13e-01 4.16e-02 6.69e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 8.22e-01 4.11e-02 9.22e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 6.45e-01 4.11e-02 8.40e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 7.15e-01 4.06e-02 8.76e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 8.24e-01 -4.06e-02 9.22e-01
NOD1 2 SIGNALING PATHWAY 35 6.80e-01 -4.03e-02 8.55e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 7.38e-01 4.03e-02 8.83e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 8.03e-01 4.00e-02 9.11e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 631 8.83e-02 3.99e-02 2.71e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 7.16e-01 -3.98e-02 8.76e-01
REGULATION OF IFNG SIGNALING 13 8.04e-01 -3.98e-02 9.11e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 6.21e-01 -3.97e-02 8.31e-01
TRANSPORT OF SMALL MOLECULES 590 1.01e-01 3.96e-02 2.98e-01
GLUCAGON TYPE LIGAND RECEPTORS 26 7.27e-01 3.96e-02 8.81e-01
GOLGI TO ER RETROGRADE TRANSPORT 120 4.57e-01 -3.94e-02 7.09e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 6.49e-01 -3.92e-02 8.41e-01
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.58e-01 3.88e-02 8.91e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 6.50e-01 -3.87e-02 8.41e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.17e-01 3.86e-02 9.22e-01
CARNITINE METABOLISM 14 8.03e-01 -3.85e-02 9.11e-01
TRIGLYCERIDE BIOSYNTHESIS 10 8.34e-01 -3.84e-02 9.28e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 14 8.04e-01 3.83e-02 9.11e-01
LONG TERM POTENTIATION 23 7.51e-01 3.83e-02 8.89e-01
RND1 GTPASE CYCLE 38 6.84e-01 3.82e-02 8.58e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.35e-01 -3.81e-02 9.28e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 56 6.27e-01 3.76e-02 8.31e-01
RNA POLYMERASE I TRANSCRIPTION 66 6.00e-01 -3.74e-02 8.18e-01
MISMATCH REPAIR 15 8.03e-01 -3.72e-02 9.11e-01
GPVI MEDIATED ACTIVATION CASCADE 31 7.24e-01 -3.67e-02 8.79e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 7.04e-01 3.66e-02 8.68e-01
VESICLE MEDIATED TRANSPORT 615 1.23e-01 -3.66e-02 3.38e-01
PI METABOLISM 79 5.75e-01 3.65e-02 8.02e-01
HCMV INFECTION 102 5.26e-01 -3.63e-02 7.68e-01
SIGNALING BY PDGF 57 6.36e-01 3.63e-02 8.33e-01
MEMBRANE TRAFFICKING 583 1.36e-01 -3.62e-02 3.54e-01
SIGNALING BY ACTIVIN 12 8.28e-01 3.61e-02 9.24e-01
INTERFERON SIGNALING 168 4.24e-01 3.58e-02 6.82e-01
INSULIN PROCESSING 24 7.62e-01 3.57e-02 8.92e-01
HIV ELONGATION ARREST AND RECOVERY 32 7.31e-01 3.51e-02 8.83e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 64 6.28e-01 -3.51e-02 8.31e-01
METABOLISM OF LIPIDS 615 1.44e-01 -3.46e-02 3.72e-01
MEIOSIS 63 6.35e-01 -3.46e-02 8.33e-01
RHOQ GTPASE CYCLE 59 6.47e-01 -3.45e-02 8.41e-01
PLATELET SENSITIZATION BY LDL 15 8.22e-01 -3.36e-02 9.22e-01
SMOOTH MUSCLE CONTRACTION 33 7.43e-01 -3.30e-02 8.83e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 8.20e-01 -3.28e-02 9.22e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 97 5.81e-01 -3.24e-02 8.06e-01
SURFACTANT METABOLISM 16 8.22e-01 3.24e-02 9.22e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 85 6.08e-01 -3.22e-02 8.25e-01
RHO GTPASES ACTIVATE PAKS 21 7.99e-01 3.21e-02 9.11e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 32 7.56e-01 3.17e-02 8.91e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 8.38e-01 3.16e-02 9.28e-01
DNA DOUBLE STRAND BREAK RESPONSE 51 6.98e-01 3.14e-02 8.63e-01
G PROTEIN BETA GAMMA SIGNALLING 31 7.62e-01 3.14e-02 8.92e-01
INFECTIOUS DISEASE 737 1.51e-01 -3.12e-02 3.79e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 6.32e-01 -3.12e-02 8.32e-01
SIGNALING BY INTERLEUKINS 355 3.17e-01 -3.10e-02 5.83e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 7.78e-01 3.08e-02 8.97e-01
TELOMERE EXTENSION BY TELOMERASE 22 8.03e-01 -3.08e-02 9.11e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 7.73e-01 3.04e-02 8.97e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 7.71e-01 -3.02e-02 8.97e-01
SIGNALLING TO ERKS 34 7.66e-01 -2.96e-02 8.94e-01
CELLULAR SENESCENCE 140 5.47e-01 2.95e-02 7.82e-01
NGF STIMULATED TRANSCRIPTION 36 7.61e-01 -2.93e-02 8.92e-01
NUCLEAR IMPORT OF REV PROTEIN 32 7.74e-01 -2.93e-02 8.97e-01
P38MAPK EVENTS 13 8.56e-01 -2.92e-02 9.37e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 8.62e-01 -2.90e-02 9.39e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 96 6.29e-01 -2.85e-02 8.31e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 7.74e-01 -2.85e-02 8.97e-01
RHOF GTPASE CYCLE 41 7.54e-01 2.83e-02 8.91e-01
ENDOSOMAL VACUOLAR PATHWAY 11 8.72e-01 -2.81e-02 9.45e-01
NUCLEOTIDE SALVAGE 21 8.25e-01 2.79e-02 9.22e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 21 8.25e-01 -2.78e-02 9.22e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 8.59e-01 2.74e-02 9.38e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 13 8.66e-01 -2.71e-02 9.42e-01
VLDLR INTERNALISATION AND DEGRADATION 12 8.71e-01 -2.71e-02 9.45e-01
GLYCOGEN METABOLISM 25 8.15e-01 2.70e-02 9.21e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 7.76e-01 -2.70e-02 8.97e-01
GLUCOSE METABOLISM 81 6.76e-01 -2.68e-02 8.52e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 8.79e-01 2.66e-02 9.50e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 7.29e-01 -2.66e-02 8.81e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 42 7.66e-01 -2.65e-02 8.94e-01
OVARIAN TUMOR DOMAIN PROTEASES 37 7.81e-01 2.64e-02 8.99e-01
SIGNALING BY ERBB2 IN CANCER 25 8.20e-01 -2.63e-02 9.22e-01
ERYTHROPOIETIN ACTIVATES RAS 13 8.74e-01 2.54e-02 9.46e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 7.69e-01 2.53e-02 8.96e-01
PEPTIDE HORMONE METABOLISM 60 7.35e-01 2.53e-02 8.83e-01
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 107 6.52e-01 -2.53e-02 8.41e-01
ACYL CHAIN REMODELLING OF PE 17 8.57e-01 -2.53e-02 9.37e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 19 8.49e-01 -2.52e-02 9.35e-01
RHOG GTPASE CYCLE 74 7.08e-01 2.52e-02 8.72e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 8.63e-01 -2.49e-02 9.40e-01
SIGNALING BY FGFR3 35 8.01e-01 2.46e-02 9.11e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 8.94e-01 -2.44e-02 9.58e-01
INTEGRIN CELL SURFACE INTERACTIONS 74 7.21e-01 -2.40e-02 8.78e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 21 8.49e-01 -2.40e-02 9.35e-01
EPH EPHRIN SIGNALING 92 6.92e-01 2.39e-02 8.61e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 8.86e-01 -2.39e-02 9.56e-01
SELENOAMINO ACID METABOLISM 110 6.68e-01 -2.37e-02 8.49e-01
ERBB2 ACTIVATES PTK6 SIGNALING 11 8.92e-01 -2.36e-02 9.58e-01
TBC RABGAPS 43 7.92e-01 -2.33e-02 9.06e-01
SIGNALING BY FGFR4 33 8.19e-01 2.30e-02 9.22e-01
CELL CELL JUNCTION ORGANIZATION 49 7.81e-01 2.29e-02 8.99e-01
APOPTOTIC EXECUTION PHASE 45 7.97e-01 -2.22e-02 9.11e-01
PARASITE INFECTION 55 7.78e-01 -2.20e-02 8.97e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 8.91e-01 2.19e-02 9.58e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 8.47e-01 -2.19e-02 9.34e-01
SIGNALING BY CSF3 G CSF 29 8.39e-01 -2.18e-02 9.28e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 171 6.33e-01 -2.12e-02 8.32e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 9.09e-01 2.09e-02 9.65e-01
ESR MEDIATED SIGNALING 166 6.49e-01 2.05e-02 8.41e-01
SYNTHESIS OF PC 27 8.54e-01 2.05e-02 9.37e-01
PI3K AKT SIGNALING IN CANCER 90 7.41e-01 -2.02e-02 8.83e-01
GAP JUNCTION DEGRADATION 11 9.08e-01 2.01e-02 9.65e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 6.46e-01 -2.01e-02 8.40e-01
BILE ACID AND BILE SALT METABOLISM 24 8.67e-01 1.97e-02 9.42e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 9.04e-01 1.94e-02 9.65e-01
SIGNALING BY VEGF 104 7.36e-01 -1.92e-02 8.83e-01
NUCLEAR ENVELOPE BREAKDOWN 49 8.21e-01 1.86e-02 9.22e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 369 5.40e-01 1.86e-02 7.77e-01
DISEASES OF DNA REPAIR 11 9.15e-01 -1.85e-02 9.70e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 288 5.90e-01 -1.85e-02 8.13e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 108 7.40e-01 -1.85e-02 8.83e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 8.55e-01 -1.84e-02 9.37e-01
COLLAGEN FORMATION 81 7.77e-01 -1.82e-02 8.97e-01
FRS MEDIATED FGFR4 SIGNALING 14 9.06e-01 1.82e-02 9.65e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 20 8.89e-01 1.80e-02 9.57e-01
SARS COV INFECTIONS 140 7.14e-01 1.80e-02 8.76e-01
CELL JUNCTION ORGANIZATION 74 7.90e-01 1.79e-02 9.06e-01
RECYCLING PATHWAY OF L1 40 8.46e-01 -1.78e-02 9.34e-01
HEDGEHOG OFF STATE 108 7.51e-01 -1.77e-02 8.89e-01
CILIUM ASSEMBLY 193 6.75e-01 -1.75e-02 8.52e-01
METABOLISM OF VITAMINS AND COFACTORS 153 7.10e-01 1.75e-02 8.72e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 8.59e-01 -1.71e-02 9.38e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 141 7.27e-01 1.70e-02 8.81e-01
MAPK FAMILY SIGNALING CASCADES 290 6.20e-01 -1.70e-02 8.31e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 8.93e-01 1.69e-02 9.58e-01
SIGNALING BY PTK6 50 8.36e-01 1.69e-02 9.28e-01
METABOLISM OF STEROIDS 114 7.61e-01 -1.65e-02 8.92e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 9.12e-01 -1.65e-02 9.68e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 11 9.25e-01 -1.65e-02 9.76e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 8.89e-01 -1.64e-02 9.57e-01
INTRAFLAGELLAR TRANSPORT 52 8.44e-01 1.58e-02 9.33e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 9.22e-01 -1.56e-02 9.75e-01
STRIATED MUSCLE CONTRACTION 28 8.87e-01 1.55e-02 9.56e-01
SIGNALING BY ERBB2 ECD MUTANTS 16 9.16e-01 1.53e-02 9.70e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 8.51e-01 1.51e-02 9.36e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 8.27e-01 -1.49e-02 9.23e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 24 9.00e-01 1.49e-02 9.62e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS 21 9.07e-01 -1.48e-02 9.65e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.85e-01 -1.48e-02 9.56e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 7.68e-01 -1.48e-02 8.96e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 23 9.03e-01 -1.47e-02 9.65e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 8.62e-01 -1.47e-02 9.39e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 9.06e-01 1.43e-02 9.65e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 186 7.43e-01 -1.40e-02 8.83e-01
REPRODUCTION 76 8.34e-01 -1.39e-02 9.28e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 149 7.71e-01 -1.38e-02 8.97e-01
HCMV EARLY EVENTS 79 8.37e-01 1.34e-02 9.28e-01
FRS MEDIATED FGFR3 SIGNALING 15 9.29e-01 1.33e-02 9.78e-01
GENE SILENCING BY RNA 81 8.37e-01 1.33e-02 9.28e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 9.43e-01 -1.30e-02 9.85e-01
GLYCOLYSIS 67 8.54e-01 -1.30e-02 9.37e-01
DNA METHYLATION 19 9.24e-01 -1.26e-02 9.76e-01
INTRA GOLGI TRAFFIC 43 8.97e-01 1.14e-02 9.60e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 102 8.43e-01 1.14e-02 9.32e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 9.46e-01 1.13e-02 9.85e-01
SIGNALING BY WNT 267 7.55e-01 1.11e-02 8.91e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 9.36e-01 1.09e-02 9.80e-01
RNA POLYMERASE III TRANSCRIPTION 41 9.05e-01 -1.08e-02 9.65e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 61 8.85e-01 1.07e-02 9.56e-01
VXPX CARGO TARGETING TO CILIUM 19 9.36e-01 1.06e-02 9.80e-01
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 9.34e-01 1.04e-02 9.80e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 8.57e-01 -1.03e-02 9.37e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 9.46e-01 -9.83e-03 9.85e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 8.71e-01 9.58e-03 9.45e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.48e-01 -8.46e-03 9.85e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 9.63e-01 8.04e-03 9.97e-01
MEIOTIC SYNAPSIS 40 9.31e-01 7.95e-03 9.78e-01
LDL CLEARANCE 16 9.57e-01 7.77e-03 9.93e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 59 9.20e-01 7.57e-03 9.74e-01
BASE EXCISION REPAIR AP SITE FORMATION 28 9.45e-01 7.49e-03 9.85e-01
EGFR DOWNREGULATION 28 9.46e-01 -7.34e-03 9.85e-01
PRC2 METHYLATES HISTONES AND DNA 28 9.51e-01 -6.72e-03 9.88e-01
SARS COV 2 INFECTION 65 9.30e-01 -6.29e-03 9.78e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 467 8.21e-01 6.12e-03 9.22e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 558 8.07e-01 -6.08e-03 9.13e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 9.36e-01 6.08e-03 9.80e-01
SIGNAL TRANSDUCTION BY L1 21 9.62e-01 6.01e-03 9.97e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 9.75e-01 5.73e-03 9.99e-01
TRANSCRIPTIONAL REGULATION BY RUNX3 94 9.30e-01 5.25e-03 9.78e-01
CROSSLINKING OF COLLAGEN FIBRILS 16 9.72e-01 -5.14e-03 9.99e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 9.72e-01 5.11e-03 9.99e-01
NONSENSE MEDIATED DECAY NMD 110 9.29e-01 -4.93e-03 9.78e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 82 9.42e-01 -4.64e-03 9.85e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 9.65e-01 4.31e-03 9.97e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 20 9.74e-01 4.27e-03 9.99e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.78e-01 -4.18e-03 9.99e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 9.45e-01 4.12e-03 9.85e-01
SIGNALING BY KIT IN DISEASE 20 9.78e-01 3.61e-03 9.99e-01
SIGNALING BY HIPPO 20 9.78e-01 3.53e-03 9.99e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 9.79e-01 3.36e-03 9.99e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.79e-01 3.32e-03 9.99e-01
AMYLOID FIBER FORMATION 56 9.66e-01 3.30e-03 9.97e-01
SPRY REGULATION OF FGF SIGNALING 16 9.82e-01 3.23e-03 9.99e-01
ENDOGENOUS STEROLS 20 9.80e-01 -3.23e-03 9.99e-01
SHC MEDIATED CASCADE FGFR4 12 9.85e-01 3.16e-03 1.00e+00
RAC2 GTPASE CYCLE 88 9.61e-01 3.00e-03 9.97e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 9.76e-01 2.89e-03 9.99e-01
HEME SIGNALING 45 9.75e-01 2.75e-03 9.99e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 9.76e-01 -2.71e-03 9.99e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 87 9.66e-01 -2.68e-03 9.97e-01
NUCLEOBASE CATABOLISM 31 9.80e-01 2.55e-03 9.99e-01
RHOH GTPASE CYCLE 37 9.81e-01 2.27e-03 9.99e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 60 9.78e-01 -2.03e-03 9.99e-01
SIGNALING BY EGFR IN CANCER 22 9.88e-01 1.91e-03 1.00e+00
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 9.86e-01 1.81e-03 1.00e+00
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 9.86e-01 -1.79e-03 1.00e+00
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 9.90e-01 -1.49e-03 1.00e+00
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 9.90e-01 -1.42e-03 1.00e+00
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 9.91e-01 1.31e-03 1.00e+00
SHC MEDIATED CASCADE FGFR3 13 9.93e-01 -1.31e-03 1.00e+00
PD 1 SIGNALING 10 9.95e-01 1.23e-03 1.00e+00
SIGNALING BY FGFR4 IN DISEASE 11 9.95e-01 -1.12e-03 1.00e+00
SIGNALING BY WNT IN CANCER 31 9.93e-01 9.62e-04 1.00e+00
CARGO CONCENTRATION IN THE ER 31 9.95e-01 -6.72e-04 1.00e+00
RETINOID CYCLE DISEASE EVENTS 10 9.97e-01 -6.68e-04 1.00e+00
EUKARYOTIC TRANSLATION ELONGATION 88 9.94e-01 -5.01e-04 1.00e+00
SCAVENGING BY CLASS A RECEPTORS 14 9.98e-01 -4.69e-04 1.00e+00
REGULATION OF PTEN GENE TRANSCRIPTION 60 9.96e-01 -4.20e-04 1.00e+00
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 9.96e-01 3.55e-04 1.00e+00
SUMOYLATION 163 9.98e-01 9.95e-05 1.00e+00
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.99e-01 9.16e-05 1.00e+00
CD209 DC SIGN SIGNALING 18 1.00e+00 3.20e-05 1.00e+00


Detailed Gene set reports



REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
818
set REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize 17
pANOVA 1.27e-05
s.dist 0.611
p.adjustANOVA 0.000557



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn11 9216
Ago2 8780
Mov10 8721
Src 8029
Tnrc6b 7816
Ago3 7792
Ago1 7427
Pml 7388
Runx1 7134
Ccnd2 6910
Cdk6 5283
Ccnd3 5010
Tnrc6c 4966
Tnrc6a 4639
Ago4 3109
Cbfb -1400
Ccnd1 -1417

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9216
Ago2 8780
Mov10 8721
Src 8029
Tnrc6b 7816
Ago3 7792
Ago1 7427
Pml 7388
Runx1 7134
Ccnd2 6910
Cdk6 5283
Ccnd3 5010
Tnrc6c 4966
Tnrc6a 4639
Ago4 3109
Cbfb -1400
Ccnd1 -1417


ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN

ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
299
set ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN
setSize 10
pANOVA 0.00198
s.dist -0.565
p.adjustANOVA 0.0221



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cyb5r1 -7231
Hbb-bt -6892
Cyb5r4 -6626
Car2 -6572
Cyb5r2 -6023
Hba-a1 -5814
Hba-a2 -4802
Car4 -2794
Aqp1 -2553
Cyb5rl 5706

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cyb5r1 -7231
Hbb-bt -6892
Cyb5r4 -6626
Car2 -6572
Cyb5r2 -6023
Hba-a1 -5814
Hba-a2 -4802
Car4 -2794
Aqp1 -2553
Cyb5rl 5706


NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
638
set NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 11
pANOVA 0.00397
s.dist 0.502
p.adjustANOVA 0.0377



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hes5 8725
Notch2 8640
Mamld1 7114
Maml2 6126
Hes1 5678
Maml3 5247
Maml1 4758
Ep300 3948
Rbpj 2968
Fcer2a 2926
Creb1 -2266

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hes5 8725
Notch2 8640
Mamld1 7114
Maml2 6126
Hes1 5678
Maml3 5247
Maml1 4758
Ep300 3948
Rbpj 2968
Fcer2a 2926
Creb1 -2266


TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
1106
set TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize 11
pANOVA 0.0047
s.dist -0.492
p.adjustANOVA 0.0429



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tlr3 -8114
Ctsk -6498
Lgmn -6322
Hsp90b1 -6219
Ctss -4519
Tlr7 -4011
Tlr9 -2782
Ctsb -2221
Ctsl -2109
Unc93b1 -1345
Cnpy3 3105

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tlr3 -8114
Ctsk -6498
Lgmn -6322
Hsp90b1 -6219
Ctss -4519
Tlr7 -4011
Tlr9 -2782
Ctsb -2221
Ctsl -2109
Unc93b1 -1345
Cnpy3 3105


ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY
36
set ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize 10
pANOVA 0.00794
s.dist 0.485
p.adjustANOVA 0.0624



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adcy6 8821
Adcy5 8012
Adcy4 7917
Adcy2 7682
Adcy3 4776
Adcy7 4456
Adcy9 3934
Adcy8 3828
Adcy1 -373
Gnal -1542

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8821
Adcy5 8012
Adcy4 7917
Adcy2 7682
Adcy3 4776
Adcy7 4456
Adcy9 3934
Adcy8 3828
Adcy1 -373
Gnal -1542


NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
642
set NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 20
pANOVA 0.000238
s.dist 0.475
p.adjustANOVA 0.00502



Top enriched genes

Top 20 genes
GeneID Gene Rank
Notch1 8999
Hes5 8725
Notch4 8676
Notch2 8640
Crebbp 7942
Mamld1 7114
Hey2 6505
Flt4 6174
Maml2 6126
Hes1 5678
Smad3 5361
Maml3 5247
Maml1 4758
Ep300 3948
Hey1 2985
Rbpj 2968
Snw1 1230
Kat2a -241
Acta2 -2738
Kat2b -4896

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 8999
Hes5 8725
Notch4 8676
Notch2 8640
Crebbp 7942
Mamld1 7114
Hey2 6505
Flt4 6174
Maml2 6126
Hes1 5678
Smad3 5361
Maml3 5247
Maml1 4758
Ep300 3948
Hey1 2985
Rbpj 2968
Snw1 1230
Kat2a -241
Acta2 -2738
Kat2b -4896


ACETYLCHOLINE REGULATES INSULIN SECRETION

ACETYLCHOLINE REGULATES INSULIN SECRETION
10
set ACETYLCHOLINE REGULATES INSULIN SECRETION
setSize 10
pANOVA 0.00956
s.dist 0.473
p.adjustANOVA 0.0712



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gna11 9159
Gna15 8747
Gnaq 8708
Plcb3 7955
Plcb2 5794
Marcks 4849
Prkca 3936
Plcb1 775
Chrm3 -764
Gna14 -2654

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gna11 9159
Gna15 8747
Gnaq 8708
Plcb3 7955
Plcb2 5794
Marcks 4849
Prkca 3936
Plcb1 775
Chrm3 -764
Gna14 -2654


A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
1
set A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS
setSize 26
pANOVA 6.9e-05
s.dist 0.451
p.adjustANOVA 0.00209



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gpc3 9164
Sdc4 9051
Ncan 8843
Cspg4 8709
Xylt2 8160
Gpc4 7880
Hspg2 7534
B4galt7 7465
B3gat2 6157
Sdc3 6007
Gpc5 5911
B3gat1 5345
Dcn 5141
Vcan 4229
Cspg5 4159
Xylt1 3986
B3galt6 3903
Gpc1 3237
Agrn 2428
Bgn 1800

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpc3 9164
Sdc4 9051
Ncan 8843
Cspg4 8709
Xylt2 8160
Gpc4 7880
Hspg2 7534
B4galt7 7465
B3gat2 6157
Sdc3 6007
Gpc5 5911
B3gat1 5345
Dcn 5141
Vcan 4229
Cspg5 4159
Xylt1 3986
B3galt6 3903
Gpc1 3237
Agrn 2428
Bgn 1800
Gpc2 1789
B3gat3 63
Bcan -609
Sdc2 -743
Sdc1 -1206
Gpc6 -2624


RUNX3 REGULATES NOTCH SIGNALING

RUNX3 REGULATES NOTCH SIGNALING
904
set RUNX3 REGULATES NOTCH SIGNALING
setSize 13
pANOVA 0.00489
s.dist 0.451
p.adjustANOVA 0.044



Top enriched genes

Top 20 genes
GeneID Gene Rank
Jag1 9047
Notch1 8999
Crebbp 7942
Mamld1 7114
Maml2 6126
Hes1 5678
Maml3 5247
Maml1 4758
Ep300 3948
Rbpj 2968
Snw1 1230
Kat2a -241
Kat2b -4896

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Jag1 9047
Notch1 8999
Crebbp 7942
Mamld1 7114
Maml2 6126
Hes1 5678
Maml3 5247
Maml1 4758
Ep300 3948
Rbpj 2968
Snw1 1230
Kat2a -241
Kat2b -4896


DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE

DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
216
set DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE
setSize 20
pANOVA 0.000561
s.dist 0.446
p.adjustANOVA 0.00899



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gpc3 9164
Sdc4 9051
Ncan 8843
Cspg4 8709
Gpc4 7880
Hspg2 7534
B4galt7 7465
Sdc3 6007
Gpc5 5911
Dcn 5141
Vcan 4229
Cspg5 4159
Gpc1 3237
Agrn 2428
Bgn 1800
Gpc2 1789
Bcan -609
Sdc2 -743
Sdc1 -1206
Gpc6 -2624

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpc3 9164
Sdc4 9051
Ncan 8843
Cspg4 8709
Gpc4 7880
Hspg2 7534
B4galt7 7465
Sdc3 6007
Gpc5 5911
Dcn 5141
Vcan 4229
Cspg5 4159
Gpc1 3237
Agrn 2428
Bgn 1800
Gpc2 1789
Bcan -609
Sdc2 -743
Sdc1 -1206
Gpc6 -2624


NOTCH HLH TRANSCRIPTION PATHWAY

NOTCH HLH TRANSCRIPTION PATHWAY
635
set NOTCH HLH TRANSCRIPTION PATHWAY
setSize 28
pANOVA 5.01e-05
s.dist 0.443
p.adjustANOVA 0.00164



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hdac5 9081
Notch1 8999
Ncor2 8830
Ncor1 8766
Notch3 8739
Notch4 8676
Notch2 8640
Hdac8 8624
Hdac4 8280
Hdac11 7987
Crebbp 7942
Hdac6 7800
Mamld1 7114
Maml2 6126
Maml3 5247
Maml1 4758
Hdac10 4673
Rbpj 2968
Tbl1x 2490
Hdac1 1732

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hdac5 9081
Notch1 8999
Ncor2 8830
Ncor1 8766
Notch3 8739
Notch4 8676
Notch2 8640
Hdac8 8624
Hdac4 8280
Hdac11 7987
Crebbp 7942
Hdac6 7800
Mamld1 7114
Maml2 6126
Maml3 5247
Maml1 4758
Hdac10 4673
Rbpj 2968
Tbl1x 2490
Hdac1 1732
Hdac7 1610
Snw1 1230
Hdac9 590
Tbl1xr1 124
Kat2a -241
Kat2b -4896
Hdac3 -6297
Hdac2 -6904


REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
792
set REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
setSize 10
pANOVA 0.017
s.dist 0.436
p.adjustANOVA 0.102



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dcc 8033
Src 8029
Slit1 7348
Ntn1 7135
Slit2 5401
Robo3 4617
Nell2 4191
Robo1 3856
Robo2 -1332
Slit3 -4016

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dcc 8033
Src 8029
Slit1 7348
Ntn1 7135
Slit2 5401
Robo3 4617
Nell2 4191
Robo1 3856
Robo2 -1332
Slit3 -4016


NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION

NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
640
set NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION
setSize 23
pANOVA 0.000347
s.dist 0.431
p.adjustANOVA 0.00645



Top enriched genes

Top 20 genes
GeneID Gene Rank
Notch1 8999
Notch3 8739
Hes5 8725
Pbx1 8385
Crebbp 7942
Ikzf1 7835
Mamld1 7114
Heyl 6800
Wwc1 6734
Hey2 6505
Maml2 6126
Hes1 5678
Maml3 5247
Plxnd1 4926
Maml1 4758
Ep300 3948
Hey1 2985
Rbpj 2968
Snw1 1230
Kat2a -241

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 8999
Notch3 8739
Hes5 8725
Pbx1 8385
Crebbp 7942
Ikzf1 7835
Mamld1 7114
Heyl 6800
Wwc1 6734
Hey2 6505
Maml2 6126
Hes1 5678
Maml3 5247
Plxnd1 4926
Maml1 4758
Ep300 3948
Hey1 2985
Rbpj 2968
Snw1 1230
Kat2a -241
Kat2b -4896
Stat1 -5672
Fabp7 -6388


MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION
571
set MITOCHONDRIAL TRANSLATION
setSize 93
pANOVA 7.3e-13
s.dist -0.43
p.adjustANOVA 4.3e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptcd3 -7941
Mtif2 -7708
Mrpl47 -7703
Mrps2 -7665
Mrpl32 -7484
Mrpl42 -7442
Mrpl1 -7429
Mrpl3 -7425
Mrps30 -7389
Mrpl16 -7244
Mrps22 -7208
Mrpl50 -7045
Mrpl18 -6985
Mrps31 -6813
Mrrf -6752
Mrpl22 -6694
Mrpl40 -6637
Chchd1 -6048
Mrps14 -6016
Mrpl10 -5932

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptcd3 -7941
Mtif2 -7708
Mrpl47 -7703
Mrps2 -7665
Mrpl32 -7484
Mrpl42 -7442
Mrpl1 -7429
Mrpl3 -7425
Mrps30 -7389
Mrpl16 -7244
Mrps22 -7208
Mrpl50 -7045
Mrpl18 -6985
Mrps31 -6813
Mrrf -6752
Mrpl22 -6694
Mrpl40 -6637
Chchd1 -6048
Mrps14 -6016
Mrpl10 -5932
Mrpl15 -5922
Mrpl35 -5803
Mrps23 -5679
Mrpl34 -5571
Mrpl11 -5416
Mrpl13 -5399
Mrps36 -5049
Mrpl21 -4899
Mrpl48 -4798
Gfm1 -4708
Mrpl51 -4678
Mrpl30 -4671
Mrpl12 -4670
Mrpl46 -4653
Mrpl39 -4580
Mrpl36 -4538
Mrps33 -4467
Mrps35 -4398
Mrps18a -4382
Mrps27 -4337
Mrps18c -4305
Mrpl33 -4190
Mrpl43 -3987
Mrps12 -3766
Mrps18b -3656
Mrpl27 -3604
Mrpl49 -3507
Mrpl20 -3440
Mrpl37 -3396
Mrps10 -3264
Gfm2 -3139
Mrps9 -2999
Mrps21 -2985
Mrpl54 -2907
Mrpl17 -2833
Oxa1l -2550
Mrpl28 -2389
Gadd45gip1 -2281
Mrps7 -2248
Mrpl44 -2112
Mrpl19 -1978
Mrpl55 -1854
Mrpl53 -1766
Mrps24 -1707
Mrpl9 -1683
Mrpl57 -1563
Mrps11 -1388
Mrpl4 -1331
Mrps25 -1217
Mrpl52 -971
Tsfm -833
Mrps16 -822
Mrpl58 -789
Mrpl24 -682
Mrps17 -544
Mrpl41 -518
Mrps15 -423
Aurkaip1 -327
Mtif3 -259
Mrpl23 -195
Mrps28 -146
Tufm 588
Mtfmt 650
Mrps6 973
Mrps26 978
Mrpl2 1103
Mrps5 1311
Mrpl14 1675
Mrps34 1923
Mrpl38 4193
Eral1 4336
Dap3 5241
Mtrf1l 6440


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
1036
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 6.19e-05
s.dist -0.43
p.adjustANOVA 0.00192



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ube2b -8104
Ube2w -8063
Ube2a -8007
Ube2g1 -8005
Uchl3 -7908
Ube2l3 -7759
Ube2d1 -7672
Ube2e1 -7614
Ube2d2a -7380
Ube2e3 -7216
Ube2k -7089
Uba6 -6485
Ube2t -6180
Ube2q2 -6095
Cdc34 -5028
Ube2s -3423
Usp9x -2842
Ube2r2 -2055
Ubb -2020
Rps27a -1712

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ube2b -8104
Ube2w -8063
Ube2a -8007
Ube2g1 -8005
Uchl3 -7908
Ube2l3 -7759
Ube2d1 -7672
Ube2e1 -7614
Ube2d2a -7380
Ube2e3 -7216
Ube2k -7089
Uba6 -6485
Ube2t -6180
Ube2q2 -6095
Cdc34 -5028
Ube2s -3423
Usp9x -2842
Ube2r2 -2055
Ubb -2020
Rps27a -1712
Usp7 -1294
Otulin 779
Ubc 798
Uba1 2534
Ube2z 3122
Usp5 3548
Uba52 5450
Ube2g2 6056
Ube2h 7329


P75NTR REGULATES AXONOGENESIS

P75NTR REGULATES AXONOGENESIS
679
set P75NTR REGULATES AXONOGENESIS
setSize 10
pANOVA 0.0196
s.dist -0.426
p.adjustANOVA 0.113



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mcf2 -8127
Omg -7605
Rtn4 -5975
Ngf -5721
Rhoa -5052
Rtn4r -4845
Mag -3666
Lingo1 242
Ngfr 781
Arhgdia 8393

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mcf2 -8127
Omg -7605
Rtn4 -5975
Ngf -5721
Rhoa -5052
Rtn4r -4845
Mag -3666
Lingo1 242
Ngfr 781
Arhgdia 8393


TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS

TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
1126
set TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
setSize 19
pANOVA 0.00133
s.dist 0.425
p.adjustANOVA 0.0165



Top enriched genes

Top 20 genes
GeneID Gene Rank
Epas1 9187
Stat3 8846
Nr5a1 8816
Hif3a 8481
Fgf2 8388
Pbx1 8385
Epha1 6596
Sall1 6236
Klf4 4296
Nr6a1 4080
Foxp1 3744
Sox2 3502
Foxd3 2754
Smad4 2273
Smad2 403
Hhex 341
Eomes -1674
Zic3 -1748
Tsc22d1 -2502

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Epas1 9187
Stat3 8846
Nr5a1 8816
Hif3a 8481
Fgf2 8388
Pbx1 8385
Epha1 6596
Sall1 6236
Klf4 4296
Nr6a1 4080
Foxp1 3744
Sox2 3502
Foxd3 2754
Smad4 2273
Smad2 403
Hhex 341
Eomes -1674
Zic3 -1748
Tsc22d1 -2502


YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION

YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
1176
set YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
setSize 12
pANOVA 0.0141
s.dist 0.409
p.adjustANOVA 0.0916



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hipk1 9090
Hipk2 9003
Tead2 8425
Tead3 7940
Tead1 7354
Yap1 6916
Runx2 6638
Tead4 5835
Ccn2 3389
Nppa -3843
Kat2b -4896
Wwtr1 -6715

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hipk1 9090
Hipk2 9003
Tead2 8425
Tead3 7940
Tead1 7354
Yap1 6916
Runx2 6638
Tead4 5835
Ccn2 3389
Nppa -3843
Kat2b -4896
Wwtr1 -6715


CRISTAE FORMATION

CRISTAE FORMATION
188
set CRISTAE FORMATION
setSize 31
pANOVA 8.21e-05
s.dist -0.409
p.adjustANOVA 0.00231



Top enriched genes

Top 20 genes
GeneID Gene Rank
Apoo -8125
Dmac2l -7964
Atp5c1 -7957
Mtx2 -7801
Atp5pb -7747
Apool -6642
Atp5o -6216
Atp5l -6120
Atp5h -5525
Atp5b -5442
Chchd3 -5369
Immt -5216
mt-Atp6 -4706
Micos10 -4068
Atp5g3 -3711
Atp5a1 -3490
Micos13 -2872
Hspa9 -2568
Atp5j2 -2335
Tmem11 -2123

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Apoo -8125
Dmac2l -7964
Atp5c1 -7957
Mtx2 -7801
Atp5pb -7747
Apool -6642
Atp5o -6216
Atp5l -6120
Atp5h -5525
Atp5b -5442
Chchd3 -5369
Immt -5216
mt-Atp6 -4706
Micos10 -4068
Atp5g3 -3711
Atp5a1 -3490
Micos13 -2872
Hspa9 -2568
Atp5j2 -2335
Tmem11 -2123
Atp5d -1654
Atp5j -1396
Chchd6 -299
Samm50 145
Mtx1 280
Atp5g1 398
Atp5g2 801
Atp5e 1074
Atp5k 2318
Dnajc11 2937
mt-Atp8 8362


REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS

REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS
798
set REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS
setSize 15
pANOVA 0.00628
s.dist 0.408
p.adjustANOVA 0.0533



Top enriched genes

Top 20 genes
GeneID Gene Rank
Notch1 8999
Crebbp 7942
Mamld1 7114
Maml2 6126
Onecut1 6083
Hes1 5678
Maml3 5247
Maml1 4758
Ep300 3948
Onecut3 3418
Rbpj 2968
Hnf1b 2818
Snw1 1230
Kat2a -241
Kat2b -4896

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notch1 8999
Crebbp 7942
Mamld1 7114
Maml2 6126
Onecut1 6083
Hes1 5678
Maml3 5247
Maml1 4758
Ep300 3948
Onecut3 3418
Rbpj 2968
Hnf1b 2818
Snw1 1230
Kat2a -241
Kat2b -4896


FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
340
set FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize 19
pANOVA 0.00253
s.dist -0.4
p.adjustANOVA 0.0269



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tuba8 -7123
Cct6a -6799
Tcp1 -6717
Tuba4a -6704
Cct4 -6509
Tubb4b -6350
Tuba1b -5485
Cct7 -5438
Cct2 -5394
Tuba1c -4834
Cct8 -4490
Tubb3 -3833
Cct5 -3393
Cct3 -1065
Tuba1a 675
Tubb4a 976
Tubb6 5057
Tubb2a 5530
Tubb2b 6231

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tuba8 -7123
Cct6a -6799
Tcp1 -6717
Tuba4a -6704
Cct4 -6509
Tubb4b -6350
Tuba1b -5485
Cct7 -5438
Cct2 -5394
Tuba1c -4834
Cct8 -4490
Tubb3 -3833
Cct5 -3393
Cct3 -1065
Tuba1a 675
Tubb4a 976
Tubb6 5057
Tubb2a 5530
Tubb2b 6231


SIGNALING BY LEPTIN

SIGNALING BY LEPTIN
968
set SIGNALING BY LEPTIN
setSize 10
pANOVA 0.0284
s.dist 0.4
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn11 9216
Stat3 8846
Stat5b 8264
Sh2b1 8203
Irs2 2951
Irs1 1960
Socs3 1333
Jak2 418
Lepr 33
Stat5a -1061

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9216
Stat3 8846
Stat5b 8264
Sh2b1 8203
Irs2 2951
Irs1 1960
Socs3 1333
Jak2 418
Lepr 33
Stat5a -1061


NR1H2 AND NR1H3 MEDIATED SIGNALING

NR1H2 AND NR1H3 MEDIATED SIGNALING
643
set NR1H2 AND NR1H3 MEDIATED SIGNALING
setSize 38
pANOVA 2.41e-05
s.dist 0.396
p.adjustANOVA 0.000948



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rxra 9068
Srebf1 8892
Ncor2 8830
Ago2 8780
Ncor1 8766
Mov10 8721
Kdm4a 8056
Tnrc6b 7816
Ago3 7792
Ago1 7427
Fasn 7242
Apoe 6650
Scd2 6102
Gps2 6003
Scd1 5868
Pltp 5735
Abca1 5679
Abcg1 5249
Tnrc6c 4966
Tnrc6a 4639

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rxra 9068
Srebf1 8892
Ncor2 8830
Ago2 8780
Ncor1 8766
Mov10 8721
Kdm4a 8056
Tnrc6b 7816
Ago3 7792
Ago1 7427
Fasn 7242
Apoe 6650
Scd2 6102
Gps2 6003
Scd1 5868
Pltp 5735
Abca1 5679
Abcg1 5249
Tnrc6c 4966
Tnrc6a 4639
Eepd1 3995
Ep300 3948
Nr1h3 3739
Kdm3a 3241
Ago4 3109
Ncoa1 2648
Rxrb 2496
Tbl1x 2490
Mylip 1690
Kdm1b 492
Tbl1xr1 124
Nr1h2 -29
Kdm1a -812
Apoc1 -835
Arl4c -2397
Apod -3647
Nrip1 -5244
Hdac3 -6297


NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX

NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
644
set NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX
setSize 32
pANOVA 0.000118
s.dist 0.393
p.adjustANOVA 0.00317



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rxra 9068
Ncor2 8830
Ago2 8780
Ncor1 8766
Mov10 8721
Kdm4a 8056
Tnrc6b 7816
Ago3 7792
Ago1 7427
Apoe 6650
Gps2 6003
Pltp 5735
Abca1 5679
Abcg1 5249
Tnrc6c 4966
Tnrc6a 4639
Eepd1 3995
Ep300 3948
Nr1h3 3739
Kdm3a 3241

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rxra 9068
Ncor2 8830
Ago2 8780
Ncor1 8766
Mov10 8721
Kdm4a 8056
Tnrc6b 7816
Ago3 7792
Ago1 7427
Apoe 6650
Gps2 6003
Pltp 5735
Abca1 5679
Abcg1 5249
Tnrc6c 4966
Tnrc6a 4639
Eepd1 3995
Ep300 3948
Nr1h3 3739
Kdm3a 3241
Ago4 3109
Ncoa1 2648
Rxrb 2496
Tbl1x 2490
Kdm1b 492
Tbl1xr1 124
Nr1h2 -29
Kdm1a -812
Apoc1 -835
Arl4c -2397
Apod -3647
Hdac3 -6297


INTERLEUKIN 6 SIGNALING

INTERLEUKIN 6 SIGNALING
483
set INTERLEUKIN 6 SIGNALING
setSize 10
pANOVA 0.0318
s.dist 0.392
p.adjustANOVA 0.151



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ptpn11 9216
Stat3 8846
Il6st 8446
Cbl 8343
Il6ra 6903
Tyk2 5685
Socs3 1333
Jak2 418
Jak1 -4063
Stat1 -5672

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ptpn11 9216
Stat3 8846
Il6st 8446
Cbl 8343
Il6ra 6903
Tyk2 5685
Socs3 1333
Jak2 418
Jak1 -4063
Stat1 -5672


FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
331
set FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize 18
pANOVA 0.00408
s.dist -0.391
p.adjustANOVA 0.0384



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dmac2l -7964
Atp5c1 -7957
Atp5pb -7747
Atp5o -6216
Atp5l -6120
Atp5h -5525
Atp5b -5442
mt-Atp6 -4706
Atp5g3 -3711
Atp5a1 -3490
Atp5j2 -2335
Atp5d -1654
Atp5j -1396
Atp5g1 398
Atp5g2 801
Atp5e 1074
Atp5k 2318
mt-Atp8 8362

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dmac2l -7964
Atp5c1 -7957
Atp5pb -7747
Atp5o -6216
Atp5l -6120
Atp5h -5525
Atp5b -5442
mt-Atp6 -4706
Atp5g3 -3711
Atp5a1 -3490
Atp5j2 -2335
Atp5d -1654
Atp5j -1396
Atp5g1 398
Atp5g2 801
Atp5e 1074
Atp5k 2318
mt-Atp8 8362


APOPTOSIS INDUCED DNA FRAGMENTATION

APOPTOSIS INDUCED DNA FRAGMENTATION
67
set APOPTOSIS INDUCED DNA FRAGMENTATION
setSize 10
pANOVA 0.0348
s.dist -0.386
p.adjustANOVA 0.156



Top enriched genes

Top 20 genes
GeneID Gene Rank
H1f0 -7563
Kpna1 -6673
Hmgb1 -5673
H1f2 -3903
Hmgb2 -3802
Dffb -3575
Dffa -3400
Casp3 -1258
H1f4 3449
Kpnb1 4352

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H1f0 -7563
Kpna1 -6673
Hmgb1 -5673
H1f2 -3903
Hmgb2 -3802
Dffb -3575
Dffa -3400
Casp3 -1258
H1f4 3449
Kpnb1 4352


E2F MEDIATED REGULATION OF DNA REPLICATION

E2F MEDIATED REGULATION OF DNA REPLICATION
272
set E2F MEDIATED REGULATION OF DNA REPLICATION
setSize 20
pANOVA 0.0031
s.dist -0.382
p.adjustANOVA 0.0312



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp2cb -8037
Orc5 -8018
Orc4 -8011
Orc6 -7649
Prim1 -7142
Ppp2ca -6584
Rb1 -5019
Orc3 -4888
Cdk1 -4536
Pola2 -4310
Orc2 -3311
Tfdp2 -2762
Ppp2r1a -1577
Pola1 -566
E2f1 -285
Mcm8 1092
Tfdp1 3188
Prim2 3596
Ppp2r1b 4009
Ppp2r3d 5360

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp2cb -8037
Orc5 -8018
Orc4 -8011
Orc6 -7649
Prim1 -7142
Ppp2ca -6584
Rb1 -5019
Orc3 -4888
Cdk1 -4536
Pola2 -4310
Orc2 -3311
Tfdp2 -2762
Ppp2r1a -1577
Pola1 -566
E2f1 -285
Mcm8 1092
Tfdp1 3188
Prim2 3596
Ppp2r1b 4009
Ppp2r3d 5360


RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
837
set RESPIRATORY ELECTRON TRANSPORT
setSize 102
pANOVA 2.96e-11
s.dist -0.381
p.adjustANOVA 8.73e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cycs -8030
Ndufaf4 -7868
mt-Co2 -7681
Ndufv2 -7655
Ndufaf1 -7468
Cox16 -7132
Ndufaf5 -7081
Uqcrc2 -6943
Ndufa10 -6619
Ndufs8 -6345
Etfa -6344
Ndufb5 -6246
Uqcrfs1 -6241
Coq10b -6236
Sco1 -6172
Sdhb -6139
Ndufs4 -5999
Ndufab1 -5905
Ndufaf2 -5869
Cox5a -5846

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8030
Ndufaf4 -7868
mt-Co2 -7681
Ndufv2 -7655
Ndufaf1 -7468
Cox16 -7132
Ndufaf5 -7081
Uqcrc2 -6943
Ndufa10 -6619
Ndufs8 -6345
Etfa -6344
Ndufb5 -6246
Uqcrfs1 -6241
Coq10b -6236
Sco1 -6172
Sdhb -6139
Ndufs4 -5999
Ndufab1 -5905
Ndufaf2 -5869
Cox5a -5846
Ndufc2 -5705
mt-Nd6 -5660
Ndufs1 -5653
Ndufaf6 -5591
Cox7b -5575
Ndufb6 -5470
mt-Co3 -5278
Ndufb10 -5235
Ndufs3 -5121
Etfdh -4903
mt-Nd1 -4841
mt-Nd2 -4778
Ndufb11 -4770
Ndufa11 -4641
Cyc1 -4446
Ndufs5 -4410
Cox6b1 -4379
Ndufa4 -4295
Cox14 -4207
Nubpl -4193
Ndufa9 -4086
Coq10a -4066
mt-Nd4 -3963
Uqcrh -3952
Ndufb2 -3708
Uqcrb -3699
Ndufb8 -3626
mt-Cytb -3522
Ndufb3 -3470
Ndufb9 -3215
Ndufc1 -3161
Surf1 -3104
Ndufa5 -2847
Sdhd -2733
Acad9 -2498
Tmem126b -2434
Cox7a2l -2392
Cox6a1 -2387
mt-Co1 -2372
Taco1 -2352
Lrpprc -2265
Uqcrc1 -2162
Cox4i1 -2089
Cox7c -2026
Ndufv1 -1901
mt-Nd5 -1898
Ndufb4 -1842
Sdhc -1458
Cox20 -1000
Cox6c -980
Ndufa1 -976
Ndufa8 -890
Cox11 -886
Trap1 -876
Ecsit -798
Ndufa6 -729
Ndufs2 -313
Uqcrq -45
Sco2 -39
Timmdc1 127
Ndufa2 192
Ndufb1 287
Ndufb7 525
Ndufv3 527
Ndufs7 539
Ndufa7 676
Ndufa12 817
Etfb 928
Ndufs6 970
Uqcr10 1018
Uqcr11 1032
Cox19 1233
Cox5b 1282
Sdha 1613
Ndufaf3 1638
Cox18 1693
Ndufa3 2455
Cox8a 2984
Ndufa13 3395
Ndufaf7 4174
mt-Nd3 4615
Tmem186 6796


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
146
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 11
pANOVA 0.029
s.dist -0.38
p.adjustANOVA 0.145



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ywhaq -7491
Chek1 -6893
Ywhab -5368
Ywhah -4971
Cdk1 -4536
Wee1 -3597
Ywhae -3459
Ywhaz -2939
Chek2 -1869
Ywhag 3508
Sfn 7281

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ywhaq -7491
Chek1 -6893
Ywhab -5368
Ywhah -4971
Cdk1 -4536
Wee1 -3597
Ywhae -3459
Ywhaz -2939
Chek2 -1869
Ywhag 3508
Sfn 7281


ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
74
set ASPARTATE AND ASPARAGINE METABOLISM
setSize 11
pANOVA 0.0292
s.dist -0.38
p.adjustANOVA 0.145



Top enriched genes

Top 20 genes
GeneID Gene Rank
Aspa -7826
Folh1 -6996
Asns -6372
Slc25a13 -5107
Got1 -4038
Got2 -3411
Gadl1 -1112
Nat8l -570
Slc25a12 1
Naalad2 1185
Aspg 3947

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Aspa -7826
Folh1 -6996
Asns -6372
Slc25a13 -5107
Got1 -4038
Got2 -3411
Gadl1 -1112
Nat8l -570
Slc25a12 1
Naalad2 1185
Aspg 3947


PHASE 2 PLATEAU PHASE

PHASE 2 PLATEAU PHASE
694
set PHASE 2 PLATEAU PHASE
setSize 12
pANOVA 0.0228
s.dist 0.38
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cacng4 9124
Kcne4 8639
Cacng8 8295
Akap9 8138
Cacna1c 6955
Cacnb1 6814
Cacna2d2 3392
Cacng7 2830
Kcne1l 1055
Cacnb2 336
Kcne2 -3117
Kcnq1 -6399

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cacng4 9124
Kcne4 8639
Cacng8 8295
Akap9 8138
Cacna1c 6955
Cacnb1 6814
Cacna2d2 3392
Cacng7 2830
Kcne1l 1055
Cacnb2 336
Kcne2 -3117
Kcnq1 -6399


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
180
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 0.00098
s.dist -0.373
p.adjustANOVA 0.0133



Top enriched genes

Top 20 genes
GeneID Gene Rank
Vbp1 -7976
Pfdn4 -7847
Tuba8 -7123
Cct6a -6799
Tcp1 -6717
Tuba4a -6704
Cct4 -6509
Tubb4b -6350
Tuba1b -5485
Cct7 -5438
Cct2 -5394
Tuba1c -4834
Cct8 -4490
Tubb3 -3833
Pfdn1 -3798
Cct5 -3393
Pfdn6 -1704
Cct3 -1065
Tuba1a 675
Tubb4a 976

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Vbp1 -7976
Pfdn4 -7847
Tuba8 -7123
Cct6a -6799
Tcp1 -6717
Tuba4a -6704
Cct4 -6509
Tubb4b -6350
Tuba1b -5485
Cct7 -5438
Cct2 -5394
Tuba1c -4834
Cct8 -4490
Tubb3 -3833
Pfdn1 -3798
Cct5 -3393
Pfdn6 -1704
Cct3 -1065
Tuba1a 675
Tubb4a 976
Pfdn5 1529
Actb 1819
Pfdn2 3530
Tubb6 5057
Tubb2a 5530
Tubb2b 6231


COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
171
set COMPLEX I BIOGENESIS
setSize 56
pANOVA 1.98e-06
s.dist -0.367
p.adjustANOVA 0.000117



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ndufaf4 -7868
Ndufv2 -7655
Ndufaf1 -7468
Ndufaf5 -7081
Ndufa10 -6619
Ndufs8 -6345
Ndufb5 -6246
Ndufs4 -5999
Ndufab1 -5905
Ndufaf2 -5869
Ndufc2 -5705
mt-Nd6 -5660
Ndufs1 -5653
Ndufaf6 -5591
Ndufb6 -5470
Ndufb10 -5235
Ndufs3 -5121
mt-Nd1 -4841
mt-Nd2 -4778
Ndufb11 -4770

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ndufaf4 -7868
Ndufv2 -7655
Ndufaf1 -7468
Ndufaf5 -7081
Ndufa10 -6619
Ndufs8 -6345
Ndufb5 -6246
Ndufs4 -5999
Ndufab1 -5905
Ndufaf2 -5869
Ndufc2 -5705
mt-Nd6 -5660
Ndufs1 -5653
Ndufaf6 -5591
Ndufb6 -5470
Ndufb10 -5235
Ndufs3 -5121
mt-Nd1 -4841
mt-Nd2 -4778
Ndufb11 -4770
Ndufa11 -4641
Ndufs5 -4410
Nubpl -4193
Ndufa9 -4086
mt-Nd4 -3963
Ndufb2 -3708
Ndufb8 -3626
Ndufb3 -3470
Ndufb9 -3215
Ndufc1 -3161
Ndufa5 -2847
Acad9 -2498
Tmem126b -2434
Ndufv1 -1901
mt-Nd5 -1898
Ndufb4 -1842
Ndufa1 -976
Ndufa8 -890
Ecsit -798
Ndufa6 -729
Ndufs2 -313
Timmdc1 127
Ndufa2 192
Ndufb1 287
Ndufb7 525
Ndufv3 527
Ndufs7 539
Ndufa7 676
Ndufa12 817
Ndufs6 970
Ndufaf3 1638
Ndufa3 2455
Ndufa13 3395
Ndufaf7 4174
mt-Nd3 4615
Tmem186 6796


DEFECTIVE EXT2 CAUSES EXOSTOSES 2

DEFECTIVE EXT2 CAUSES EXOSTOSES 2
218
set DEFECTIVE EXT2 CAUSES EXOSTOSES 2
setSize 14
pANOVA 0.0175
s.dist 0.367
p.adjustANOVA 0.103



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gpc3 9164
Sdc4 9051
Gpc4 7880
Hspg2 7534
Sdc3 6007
Gpc5 5911
Ext2 4928
Gpc1 3237
Agrn 2428
Gpc2 1789
Sdc2 -743
Ext1 -1182
Sdc1 -1206
Gpc6 -2624

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gpc3 9164
Sdc4 9051
Gpc4 7880
Hspg2 7534
Sdc3 6007
Gpc5 5911
Ext2 4928
Gpc1 3237
Agrn 2428
Gpc2 1789
Sdc2 -743
Ext1 -1182
Sdc1 -1206
Gpc6 -2624


ACTIVATION OF SMO

ACTIVATION OF SMO
27
set ACTIVATION OF SMO
setSize 16
pANOVA 0.0113
s.dist 0.366
p.adjustANOVA 0.0788



Top enriched genes

Top 20 genes
GeneID Gene Rank
Arrb1 9183
Evc 8993
Gas8 8538
Smo 7048
Iqce 6496
Ptch1 6098
Kif3a 6075
Cdon 4380
Arrb2 3721
Evc2 3417
Grk2 2586
Efcab7 272
Boc -49
Gas1 -76
Shh -767
Csnk1a1 -6441

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Arrb1 9183
Evc 8993
Gas8 8538
Smo 7048
Iqce 6496
Ptch1 6098
Kif3a 6075
Cdon 4380
Arrb2 3721
Evc2 3417
Grk2 2586
Efcab7 272
Boc -49
Gas1 -76
Shh -767
Csnk1a1 -6441


TRAF3 DEPENDENT IRF ACTIVATION PATHWAY

TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
1101
set TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
setSize 13
pANOVA 0.0228
s.dist 0.365
p.adjustANOVA 0.122



Top enriched genes

Top 20 genes
GeneID Gene Rank
Traf3 8935
Mavs 8896
Crebbp 7942
Irf3 6741
Sike1 6195
Ikbke 5562
Ep300 3948
Ddx58 2906
Rnf135 1572
Ifih1 1500
Irf7 442
Trim25 -926
Tbk1 -5507

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Traf3 8935
Mavs 8896
Crebbp 7942
Irf3 6741
Sike1 6195
Ikbke 5562
Ep300 3948
Ddx58 2906
Rnf135 1572
Ifih1 1500
Irf7 442
Trim25 -926
Tbk1 -5507


INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS
462
set INTERACTION BETWEEN L1 AND ANKYRINS
setSize 27
pANOVA 0.00104
s.dist 0.365
p.adjustANOVA 0.0137



Top enriched genes

Top 20 genes
GeneID Gene Rank
Scn5a 8330
Sptbn4 8118
Sptbn5 7957
Scn2b 7941
Sptbn1 7674
Scn3b 7515
Scn3a 7338
Nfasc 7214
Ank2 7085
Kcnq2 7046
Kcnq3 6351
Sptbn2 6241
L1cam 5044
Scn7a 4955
Sptan1 4939
Scn2a 4473
Sptb 4393
Scn9a 2520
Actb 1819
Ank3 1757

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Scn5a 8330
Sptbn4 8118
Sptbn5 7957
Scn2b 7941
Sptbn1 7674
Scn3b 7515
Scn3a 7338
Nfasc 7214
Ank2 7085
Kcnq2 7046
Kcnq3 6351
Sptbn2 6241
L1cam 5044
Scn7a 4955
Sptan1 4939
Scn2a 4473
Sptb 4393
Scn9a 2520
Actb 1819
Ank3 1757
Scn8a 875
Nrcam 500
Ank1 291
Scn4b -4559
Actg1 -4823
Scn1a -5327
Scn1b -5618


NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS

NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS
596
set NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS
setSize 15
pANOVA 0.0151
s.dist 0.362
p.adjustANOVA 0.0954



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc6a7 9086
Slc6a6 8801
Slc6a11 8629
Slc6a9 8019
Slc6a1 7336
Slc22a2 6592
Slc18a2 5632
Slc6a2 5066
Slc6a20a 3305
Slc6a19 2351
Slc6a13 1499
Slc6a3 1455
Slc6a12 -2737
Slc6a15 -3630
Slc6a5 -6079

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc6a7 9086
Slc6a6 8801
Slc6a11 8629
Slc6a9 8019
Slc6a1 7336
Slc22a2 6592
Slc18a2 5632
Slc6a2 5066
Slc6a20a 3305
Slc6a19 2351
Slc6a13 1499
Slc6a3 1455
Slc6a12 -2737
Slc6a15 -3630
Slc6a5 -6079


RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
838
set RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize 125
pANOVA 2.83e-12
s.dist -0.362
p.adjustANOVA 1.11e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cycs -8030
Dmac2l -7964
Atp5c1 -7957
Ndufaf4 -7868
Atp5pb -7747
mt-Co2 -7681
Ndufv2 -7655
Ndufaf1 -7468
Cox16 -7132
Ndufaf5 -7081
Uqcrc2 -6943
Ndufa10 -6619
Ndufs8 -6345
Etfa -6344
Ndufb5 -6246
Uqcrfs1 -6241
Coq10b -6236
Atp5o -6216
Sco1 -6172
Sdhb -6139

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cycs -8030
Dmac2l -7964
Atp5c1 -7957
Ndufaf4 -7868
Atp5pb -7747
mt-Co2 -7681
Ndufv2 -7655
Ndufaf1 -7468
Cox16 -7132
Ndufaf5 -7081
Uqcrc2 -6943
Ndufa10 -6619
Ndufs8 -6345
Etfa -6344
Ndufb5 -6246
Uqcrfs1 -6241
Coq10b -6236
Atp5o -6216
Sco1 -6172
Sdhb -6139
Atp5l -6120
Ndufs4 -5999
Ndufab1 -5905
Ndufaf2 -5869
Cox5a -5846
Ndufc2 -5705
mt-Nd6 -5660
Ndufs1 -5653
Ndufaf6 -5591
Cox7b -5575
Atp5h -5525
Ndufb6 -5470
Atp5b -5442
mt-Co3 -5278
Ndufb10 -5235
Ndufs3 -5121
Etfdh -4903
mt-Nd1 -4841
mt-Nd2 -4778
Ndufb11 -4770
Ucp3 -4764
mt-Atp6 -4706
Ndufa11 -4641
Cyc1 -4446
Ndufs5 -4410
Cox6b1 -4379
Ndufa4 -4295
Cox14 -4207
Nubpl -4193
Ndufa9 -4086
Coq10a -4066
mt-Nd4 -3963
Uqcrh -3952
Atp5g3 -3711
Ndufb2 -3708
Uqcrb -3699
Ndufb8 -3626
mt-Cytb -3522
Atp5a1 -3490
Ndufb3 -3470
Ndufb9 -3215
Ndufc1 -3161
Surf1 -3104
Ndufa5 -2847
Sdhd -2733
Acad9 -2498
Tmem126b -2434
Cox7a2l -2392
Cox6a1 -2387
mt-Co1 -2372
Taco1 -2352
Atp5j2 -2335
Lrpprc -2265
Uqcrc1 -2162
Cox4i1 -2089
Cox7c -2026
Ndufv1 -1901
mt-Nd5 -1898
Ndufb4 -1842
Atp5d -1654
Sdhc -1458
Atp5j -1396
Cox20 -1000
Cox6c -980
Ndufa1 -976
Ndufa8 -890
Cox11 -886
Trap1 -876
Ecsit -798
Ndufa6 -729
Ndufs2 -313
Uqcrq -45
Sco2 -39
Timmdc1 127
Ndufa2 192
Ndufb1 287
Atp5g1 398
Ndufb7 525
Ndufv3 527
Ndufs7 539
Ndufa7 676
Atp5g2 801
Ndufa12 817
Etfb 928
Ndufs6 970
Slc25a14 1016
Uqcr10 1018
Uqcr11 1032
Atp5e 1074
Cox19 1233
Cox5b 1282
Sdha 1613
Ndufaf3 1638
Cox18 1693
Slc25a27 1706
Atp5k 2318
Ndufa3 2455
Pm20d1 2517
Cox8a 2984
Ndufa13 3395
Ndufaf7 4174
mt-Nd3 4615
Tmem186 6796
mt-Atp8 8362
Ucp2 8829


CITRIC ACID CYCLE TCA CYCLE

CITRIC ACID CYCLE TCA CYCLE
154
set CITRIC ACID CYCLE TCA CYCLE
setSize 22
pANOVA 0.0034
s.dist -0.361
p.adjustANOVA 0.0331



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dld -8061
Sucla2 -7990
Fahd1 -7791
Me3 -7329
Suclg1 -6600
Idh3a -6468
Sdhb -6139
Idh3g -6105
Fh1 -4681
Mdh2 -4198
Aco2 -3962
Idh3b -3767
Sdhd -2733
Me2 -2243
Sdhc -1458
Cs -689
Nnt 958
Sdha 1613
Dlst 2214
Ogdh 2892

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dld -8061
Sucla2 -7990
Fahd1 -7791
Me3 -7329
Suclg1 -6600
Idh3a -6468
Sdhb -6139
Idh3g -6105
Fh1 -4681
Mdh2 -4198
Aco2 -3962
Idh3b -3767
Sdhd -2733
Me2 -2243
Sdhc -1458
Cs -689
Nnt 958
Sdha 1613
Dlst 2214
Ogdh 2892
Suclg2 6469
Idh2 9145


MITOCHONDRIAL PROTEIN IMPORT

MITOCHONDRIAL PROTEIN IMPORT
570
set MITOCHONDRIAL PROTEIN IMPORT
setSize 63
pANOVA 7.97e-07
s.dist -0.36
p.adjustANOVA 6.26e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mtx2 -7801
Timm8a1 -7662
Cmc4 -7636
Timm21 -7062
Tomm70a -7009
Pmpcb -6783
Timm23 -6713
Slc25a4 -6586
Chchd5 -6361
Cmc2 -6357
Idh3g -6105
Hspd1 -5886
Timm44 -5756
Chchd7 -5498
Atp5b -5442
Chchd3 -5369
Chchd2 -5111
Slc25a13 -5107
Grpel2 -5016
Tomm22 -4986

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mtx2 -7801
Timm8a1 -7662
Cmc4 -7636
Timm21 -7062
Tomm70a -7009
Pmpcb -6783
Timm23 -6713
Slc25a4 -6586
Chchd5 -6361
Cmc2 -6357
Idh3g -6105
Hspd1 -5886
Timm44 -5756
Chchd7 -5498
Atp5b -5442
Chchd3 -5369
Chchd2 -5111
Slc25a13 -5107
Grpel2 -5016
Tomm22 -4986
Timm9 -4937
Cyc1 -4446
Fxn -4392
Vdac1 -4135
Aco2 -3962
Tomm20 -3686
Ndufb8 -3626
Atp5a1 -3490
Timm50 -3352
Taz -2875
Hspa9 -2568
Timm10b -2323
Chchd4 -2298
Dnajc19 -2238
Timm8b -2171
Ldhd -2168
Pitrm1 -1889
Pmpca -1849
Chchd10 -1806
Tomm5 -1781
Timm17a -1444
Tomm7 -721
Cs -689
Timm10 -414
Hscb -401
Coa6 -389
Slc25a12 1
Grpel1 11
Samm50 145
Mtx1 280
Atp5g1 398
Gfer 415
Pam16 912
Coa4 923
Timm17b 1088
Cox17 1172
Cox19 1233
Timm13 1374
Timm22 2588
Tomm6 2820
Bcs1l 3575
Coq2 3973
Tomm40 5499


ORGANIC CATION ANION ZWITTERION TRANSPORT

ORGANIC CATION ANION ZWITTERION TRANSPORT
670
set ORGANIC CATION ANION ZWITTERION TRANSPORT
setSize 12
pANOVA 0.0322
s.dist 0.357
p.adjustANOVA 0.152



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc22a18 8860
Runx1 7134
Slc22a12 7133
Slc22a3 6810
Slc22a2 6592
Rsc1a1 4896
Slc22a6 3767
Slc22a4 2861
Slc22a7 2693
Slc22a15 -10
Slc22a8 -3395
Slc22a5 -3627

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc22a18 8860
Runx1 7134
Slc22a12 7133
Slc22a3 6810
Slc22a2 6592
Rsc1a1 4896
Slc22a6 3767
Slc22a4 2861
Slc22a7 2693
Slc22a15 -10
Slc22a8 -3395
Slc22a5 -3627


CHOLESTEROL BIOSYNTHESIS

CHOLESTEROL BIOSYNTHESIS
147
set CHOLESTEROL BIOSYNTHESIS
setSize 24
pANOVA 0.00249
s.dist -0.357
p.adjustANOVA 0.0267



Top enriched genes

Top 20 genes
GeneID Gene Rank
Idi1 -8021
Ggps1 -7744
Msmo1 -7742
Hsd17b7 -7406
Nsdhl -7281
Cyp51 -7217
Plpp6 -6287
Hmgcs1 -5833
Fdft1 -5530
Sqle -3976
Ebp -3120
Dhcr7 -3051
Mvd -3001
Fdps -2857
Lbr -2856
Acat3 -1840
Hmgcr -872
Arv1 648
Pmvk 1853
Sc5d 2342

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Idi1 -8021
Ggps1 -7744
Msmo1 -7742
Hsd17b7 -7406
Nsdhl -7281
Cyp51 -7217
Plpp6 -6287
Hmgcs1 -5833
Fdft1 -5530
Sqle -3976
Ebp -3120
Dhcr7 -3051
Mvd -3001
Fdps -2857
Lbr -2856
Acat3 -1840
Hmgcr -872
Arv1 648
Pmvk 1853
Sc5d 2342
Tm7sf2 3669
Mvk 4049
Lss 4547
Dhcr24 6308


TNFR1 INDUCED PROAPOPTOTIC SIGNALING

TNFR1 INDUCED PROAPOPTOTIC SIGNALING
1085
set TNFR1 INDUCED PROAPOPTOTIC SIGNALING
setSize 12
pANOVA 0.033
s.dist 0.356
p.adjustANOVA 0.153



Top enriched genes

Top 20 genes
GeneID Gene Rank
Otud7b 8178
Ripk1 7898
Usp2 7736
Cyld 5832
Usp21 5544
Fadd 4418
Tnfaip3 3424
Tnfrsf1a 3382
Usp4 2900
Traf2 1889
Casp8 -3463
Tradd -4194

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Otud7b 8178
Ripk1 7898
Usp2 7736
Cyld 5832
Usp21 5544
Fadd 4418
Tnfaip3 3424
Tnfrsf1a 3382
Usp4 2900
Traf2 1889
Casp8 -3463
Tradd -4194


SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER

SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER
974
set SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER
setSize 15
pANOVA 0.0173
s.dist 0.355
p.adjustANOVA 0.103



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mib2 9212
Jag2 9163
Jag1 9047
Notch1 8999
Neurl1b 7247
Uba52 5450
Adam17 5067
Dll1 3321
Mib1 1763
Ubc 798
Adam10 27
Neurl1a -825
Dll4 -1180
Rps27a -1712
Ubb -2020

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mib2 9212
Jag2 9163
Jag1 9047
Notch1 8999
Neurl1b 7247
Uba52 5450
Adam17 5067
Dll1 3321
Mib1 1763
Ubc 798
Adam10 27
Neurl1a -825
Dll4 -1180
Rps27a -1712
Ubb -2020


AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE

AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE
50
set AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE
setSize 27
pANOVA 0.00152
s.dist 0.353
p.adjustANOVA 0.0181



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc7a2 8957
Slc6a6 8801
Slc36a2 8668
Slc7a5 8536
Slc7a7 8460
Slc7a3 7879
Slc43a2 6724
Slc1a5 6648
Slc38a1 6593
Slc3a2 6446
Slc7a11 6116
Slc7a8 5850
Slc1a4 5829
Slc7a1 5812
Slc25a29 4349
Slc38a2 3373
Slc36a1 3366
Slc6a20a 3305
Slc6a19 2351
Slc7a10 -463

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc7a2 8957
Slc6a6 8801
Slc36a2 8668
Slc7a5 8536
Slc7a7 8460
Slc7a3 7879
Slc43a2 6724
Slc1a5 6648
Slc38a1 6593
Slc3a2 6446
Slc7a11 6116
Slc7a8 5850
Slc1a4 5829
Slc7a1 5812
Slc25a29 4349
Slc38a2 3373
Slc36a1 3366
Slc6a20a 3305
Slc6a19 2351
Slc7a10 -463
Slc38a3 -732
Slc7a6 -883
Slc36a4 -957
Slc6a12 -2737
Slc6a15 -3630
Slc16a10 -5299
Slc38a5 -6146


PENTOSE PHOSPHATE PATHWAY

PENTOSE PHOSPHATE PATHWAY
686
set PENTOSE PHOSPHATE PATHWAY
setSize 13
pANOVA 0.0285
s.dist -0.351
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpe -7664
Rbks -7342
Prps2 -6922
Pgm2 -5824
Shpk -5730
Taldo1 -4832
Dera -4718
G6pdx -2577
Rpia -680
Tkt 1010
Prps1 1285
Pgls 4033
Pgd 7422

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpe -7664
Rbks -7342
Prps2 -6922
Pgm2 -5824
Shpk -5730
Taldo1 -4832
Dera -4718
G6pdx -2577
Rpia -680
Tkt 1010
Prps1 1285
Pgls 4033
Pgd 7422


PKA ACTIVATION IN GLUCAGON SIGNALLING

PKA ACTIVATION IN GLUCAGON SIGNALLING
710
set PKA ACTIVATION IN GLUCAGON SIGNALLING
setSize 16
pANOVA 0.0152
s.dist 0.351
p.adjustANOVA 0.0954



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adcy6 8821
Adcy5 8012
Adcy4 7917
Adcy2 7682
Prkaca 5534
Adcy3 4776
Adcy7 4456
Gnas 4019
Adcy9 3934
Adcy8 3828
Prkar2a 2314
Prkar2b 738
Prkar1b 586
Adcy1 -373
Prkacb -1783
Prkar1a -3106

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8821
Adcy5 8012
Adcy4 7917
Adcy2 7682
Prkaca 5534
Adcy3 4776
Adcy7 4456
Gnas 4019
Adcy9 3934
Adcy8 3828
Prkar2a 2314
Prkar2b 738
Prkar1b 586
Adcy1 -373
Prkacb -1783
Prkar1a -3106


ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY
37
set ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize 13
pANOVA 0.0292
s.dist 0.349
p.adjustANOVA 0.145



Top enriched genes

Top 20 genes
GeneID Gene Rank
Adcy6 8821
Gnai2 8537
Adcy5 8012
Adcy4 7917
Adcy2 7682
Adcy3 4776
Adcy7 4456
Adcy9 3934
Adcy8 3828
Adcy1 -373
Gnal -1542
Gnai3 -4516
Gnai1 -5063

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Adcy6 8821
Gnai2 8537
Adcy5 8012
Adcy4 7917
Adcy2 7682
Adcy3 4776
Adcy7 4456
Adcy9 3934
Adcy8 3828
Adcy1 -373
Gnal -1542
Gnai3 -4516
Gnai1 -5063


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] parallel  stats4    stats     graphics  grDevices utils     datasets 
## [8] methods   base     
## 
## other attached packages:
##  [1] pkgload_1.2.4               GGally_2.1.2               
##  [3] gtools_3.9.2                echarts4r_0.4.3            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7                  kableExtra_1.3.4           
##  [9] topconfects_1.8.0           limma_3.48.3               
## [11] eulerr_6.1.1                mitch_1.4.1                
## [13] MASS_7.3-55                 fgsea_1.18.0               
## [15] gplots_3.1.1                DESeq2_1.32.0              
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0             
## [19] MatrixGenerics_1.4.3        matrixStats_0.61.0         
## [21] GenomicRanges_1.44.0        GenomeInfoDb_1.28.4        
## [23] IRanges_2.26.0              S4Vectors_0.30.2           
## [25] BiocGenerics_0.38.0         reshape2_1.4.4             
## [27] forcats_0.5.1               stringr_1.4.0              
## [29] dplyr_1.0.8                 purrr_0.3.4                
## [31] readr_2.1.2                 tidyr_1.2.0                
## [33] tibble_3.1.6                ggplot2_3.3.5              
## [35] tidyverse_1.3.1             zoo_1.8-9                  
## 
## loaded via a namespace (and not attached):
##   [1] readxl_1.3.1           backports_1.4.1        fastmatch_1.1-3       
##   [4] systemfonts_1.0.3      plyr_1.8.6             polylabelr_0.2.0      
##   [7] splines_4.1.3          BiocParallel_1.26.2    digest_0.6.29         
##  [10] htmltools_0.5.2        fansi_1.0.2            magrittr_2.0.2        
##  [13] memoise_2.0.1          tzdb_0.2.0             Biostrings_2.60.2     
##  [16] annotate_1.70.0        modelr_0.1.8           svglite_2.1.0         
##  [19] prettyunits_1.1.1      colorspace_2.0-2       blob_1.2.2            
##  [22] rvest_1.0.2            haven_2.4.3            xfun_0.29             
##  [25] crayon_1.4.2           RCurl_1.98-1.6         jsonlite_1.7.3        
##  [28] genefilter_1.74.1      survival_3.2-13        glue_1.6.1            
##  [31] polyclip_1.10-0        gtable_0.3.0           zlibbioc_1.38.0       
##  [34] XVector_0.32.0         webshot_0.5.2          DelayedArray_0.18.0   
##  [37] scales_1.1.1           DBI_1.1.2              Rcpp_1.0.8            
##  [40] progress_1.2.2         viridisLite_0.4.0      xtable_1.8-4          
##  [43] bit_4.0.4              htmlwidgets_1.5.4      httr_1.4.2            
##  [46] RColorBrewer_1.1-2     ellipsis_0.3.2         farver_2.1.0          
##  [49] pkgconfig_2.0.3        reshape_0.8.8          XML_3.99-0.8          
##  [52] sass_0.4.0             dbplyr_2.1.1           locfit_1.5-9.4        
##  [55] utf8_1.2.2             labeling_0.4.2         tidyselect_1.1.1      
##  [58] rlang_1.0.1            later_1.3.0            AnnotationDbi_1.54.1  
##  [61] munsell_0.5.0          cellranger_1.1.0       tools_4.1.3           
##  [64] cachem_1.0.6           cli_3.1.1              generics_0.1.2        
##  [67] RSQLite_2.2.9          broom_0.7.12           evaluate_0.14         
##  [70] fastmap_1.1.0          yaml_2.2.2             knitr_1.37            
##  [73] bit64_4.0.5            fs_1.5.2               caTools_1.18.2        
##  [76] KEGGREST_1.32.0        mime_0.12              xml2_1.3.3            
##  [79] compiler_4.1.3         rstudioapi_0.13        png_0.1-7             
##  [82] reprex_2.0.1           geneplotter_1.70.0     bslib_0.3.1           
##  [85] stringi_1.7.6          highr_0.9              desc_1.4.0            
##  [88] lattice_0.20-45        Matrix_1.4-0           vctrs_0.3.8           
##  [91] pillar_1.7.0           lifecycle_1.0.1        jquerylib_0.1.4       
##  [94] data.table_1.14.2      bitops_1.0-7           httpuv_1.6.5          
##  [97] R6_2.5.1               promises_1.2.0.1       KernSmooth_2.23-20    
## [100] gridExtra_2.3          assertthat_0.2.1       rprojroot_2.0.2       
## [103] withr_2.4.3            GenomeInfoDbData_1.2.6 hms_1.1.1             
## [106] grid_4.1.3             rmarkdown_2.11         shiny_1.7.1           
## [109] lubridate_1.8.0

END of report