Mitch Report
Antony Kaspi & Mark Ziemann
date generated: 2022-03-15
Background
Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch
Input profiles
Here is the first few lines of the input profile.
## hyp amy hip pag ni
## 0610009B22Rik 0.09722066 1.831236577 -2.2697336 0.45655760 -1.1332185
## 0610009E02Rik 1.26326253 -0.103702849 -0.3519839 -0.40699076 -0.3290659
## 0610009L18Rik -0.66374969 -0.075637695 -0.9139963 -0.18691102 0.1306738
## 0610010K14Rik -0.45368981 0.417670579 -0.1751685 -0.37114848 -0.3126674
## 0610012G03Rik 0.12236243 0.008709563 0.5678859 -0.34216334 -0.2034285
## 0610030E20Rik -0.04562294 -1.609523779 1.4359134 0.08425395 -0.5747514| Profile metrics | |
|---|---|
| num_genes_in_profile | 15857 |
| duplicated_genes_present | 0 |
| num_profile_genes_in_sets | 8073 |
| num_profile_genes_not_in_sets | 7784 |
Here is a plot of the input profiles. Note the dynamic ranges. 
Here is the contour plot of the profile including all detected genes. 
Input genesets
Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt| Gene sets metrics | |
|---|---|
| num_genesets | 1604 |
| num_genesets_excluded | 444 |
| num_genesets_included | 1160 |
| hyp | amy | hip | pag | ni | Count | |
|---|---|---|---|---|---|---|
| 1 | -1 | -1 | -1 | -1 | -1 | 506 |
| 2 | 1 | -1 | -1 | -1 | -1 | 354 |
| 3 | 1 | 0 | -1 | -1 | -1 | 1 |
| 4 | -1 | 1 | -1 | -1 | -1 | 489 |
| 5 | 1 | 1 | -1 | -1 | -1 | 828 |
| 6 | -1 | -1 | 1 | -1 | -1 | 410 |
| 7 | 1 | -1 | 1 | -1 | -1 | 241 |
| 8 | -1 | 1 | 1 | -1 | -1 | 134 |
| 9 | 1 | 1 | 1 | -1 | -1 | 133 |
| 10 | -1 | 1 | -1 | 0 | -1 | 1 |
| 11 | -1 | -1 | -1 | 1 | -1 | 383 |
| 12 | 1 | -1 | -1 | 1 | -1 | 231 |
| 13 | -1 | 1 | -1 | 1 | -1 | 1091 |
| 14 | 1 | 1 | -1 | 1 | -1 | 1306 |
| 15 | -1 | -1 | 1 | 1 | -1 | 531 |
| 16 | 1 | -1 | 1 | 1 | -1 | 233 |
| 17 | -1 | 1 | 1 | 1 | -1 | 302 |
| 18 | 0 | 1 | 1 | 1 | -1 | 1 |
| 19 | 1 | 1 | 1 | 1 | -1 | 274 |
| 20 | -1 | 1 | -1 | 1 | 0 | 1 |
| 21 | -1 | -1 | -1 | -1 | 1 | 335 |
| 22 | 1 | -1 | -1 | -1 | 1 | 455 |
| 23 | -1 | 1 | -1 | -1 | 1 | 192 |
| 24 | 1 | 1 | -1 | -1 | 1 | 529 |
| 25 | -1 | -1 | 1 | -1 | 1 | 1045 |
| 26 | 1 | -1 | 1 | -1 | 1 | 810 |
| 27 | -1 | 1 | 1 | -1 | 1 | 179 |
| 28 | 1 | 1 | 1 | -1 | 1 | 328 |
| 29 | -1 | -1 | -1 | 1 | 1 | 186 |
| 30 | 1 | -1 | -1 | 1 | 1 | 167 |
| 31 | -1 | 1 | -1 | 1 | 1 | 234 |
| 32 | 1 | 1 | -1 | 1 | 1 | 541 |
| 33 | 1 | 1 | 0 | 1 | 1 | 1 |
| 34 | -1 | -1 | 1 | 1 | 1 | 1300 |
| 35 | 1 | -1 | 1 | 1 | 1 | 837 |
| 36 | -1 | 1 | 1 | 1 | 1 | 513 |
| 37 | 1 | 1 | 1 | 1 | 1 | 755 |
Gene sets by sector
| s.hyp | s.amy | s.hip | s.pag | s.ni | Count | |
|---|---|---|---|---|---|---|
| 1 | -1 | -1 | -1 | -1 | -1 | 5 |
| 2 | -1 | 1 | -1 | -1 | -1 | 2 |
| 3 | 1 | 1 | -1 | -1 | -1 | 70 |
| 4 | -1 | -1 | 1 | -1 | -1 | 11 |
| 5 | -1 | -1 | -1 | 1 | -1 | 3 |
| 6 | -1 | 1 | -1 | 1 | -1 | 25 |
| 7 | 1 | 1 | -1 | 1 | -1 | 84 |
| 8 | -1 | -1 | 1 | 1 | -1 | 14 |
| 9 | -1 | 1 | 1 | 1 | -1 | 21 |
| 10 | 1 | 1 | 1 | 1 | -1 | 3 |
| 11 | 1 | 1 | -1 | -1 | 1 | 8 |
| 12 | -1 | -1 | 1 | -1 | 1 | 20 |
| 13 | 1 | -1 | 1 | -1 | 1 | 7 |
| 14 | -1 | 1 | 1 | -1 | 1 | 1 |
| 15 | 1 | 1 | 1 | -1 | 1 | 4 |
| 16 | -1 | -1 | -1 | 1 | 1 | 1 |
| 17 | -1 | 1 | -1 | 1 | 1 | 8 |
| 18 | 1 | 1 | -1 | 1 | 1 | 31 |
| 19 | -1 | -1 | 1 | 1 | 1 | 33 |
| 20 | 1 | -1 | 1 | 1 | 1 | 7 |
| 21 | -1 | 1 | 1 | 1 | 1 | 29 |
| 22 | 1 | 1 | 1 | 1 | 1 | 26 |
Interactive enrichment scatterplot
All sets with FDR<0.05. Try hovering over the points.
Top N sets irrespective of FDR. Try hovering over the points.
A heatmap of S values for top results
A plot of effect size versus significance
Significance is the -log2(p.adjustMANOVA) and effect size is the s.dist which is the hypotenuse of the s scores.
Results table
Top N= 50 gene sets| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.hyp | s.amy | s.hip | s.pag | s.ni | p.hyp | p.amy | p.hip | p.pag | p.ni |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EUKARYOTIC TRANSLATION ELONGATION | 87 | 2.18e-55 | 1.27e-52 | 1.130 | 0.7590 | 0.50600 | -0.5680 | -0.34200 | -0.00591 | 1.61e-34 | 3.15e-16 | 5.18e-20 | 3.61e-08 | 9.24e-01 |
| SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 106 | 1.50e-53 | 5.81e-51 | 1.020 | 0.6790 | 0.48200 | -0.5360 | -0.25200 | -0.02970 | 1.19e-33 | 9.62e-18 | 1.41e-21 | 7.51e-06 | 5.97e-01 |
| RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY | 94 | 2.62e-48 | 6.08e-46 | 1.020 | 0.6580 | 0.45900 | -0.5300 | -0.34100 | -0.03780 | 2.50e-28 | 1.41e-14 | 6.09e-19 | 1.17e-08 | 5.26e-01 |
| COMPLEX I BIOGENESIS | 56 | 6.50e-25 | 4.43e-23 | 1.020 | 0.5240 | 0.52900 | -0.4900 | -0.32200 | -0.36400 | 1.16e-11 | 7.71e-12 | 2.29e-10 | 3.03e-05 | 2.48e-06 |
| EUKARYOTIC TRANSLATION INITIATION | 114 | 1.10e-51 | 3.18e-49 | 0.987 | 0.6320 | 0.46600 | -0.5440 | -0.23200 | -0.08240 | 1.68e-31 | 8.59e-18 | 1.05e-23 | 1.85e-05 | 1.29e-01 |
| FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 18 | 7.33e-07 | 8.59e-06 | 0.959 | 0.5450 | 0.47600 | -0.4190 | -0.26600 | -0.38800 | 6.34e-05 | 4.74e-04 | 2.10e-03 | 5.07e-02 | 4.38e-03 |
| ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 59 | 3.50e-22 | 2.03e-20 | 0.946 | 0.5880 | 0.47200 | -0.5480 | -0.10100 | -0.13000 | 5.30e-15 | 3.69e-10 | 3.40e-13 | 1.79e-01 | 8.38e-02 |
| RESPIRATORY ELECTRON TRANSPORT | 102 | 2.82e-39 | 3.14e-37 | 0.944 | 0.4630 | 0.50400 | -0.4530 | -0.27100 | -0.37800 | 6.25e-16 | 1.31e-18 | 2.63e-15 | 2.28e-06 | 4.50e-11 |
| REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO | 10 | 1.15e-03 | 5.67e-03 | 0.941 | -0.6280 | -0.31100 | 0.4450 | 0.09860 | 0.43200 | 5.85e-04 | 8.86e-02 | 1.48e-02 | 5.89e-01 | 1.81e-02 |
| TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | 11 | 3.27e-03 | 1.31e-02 | 0.935 | 0.0864 | 0.64700 | -0.4570 | 0.02500 | -0.48900 | 6.20e-01 | 2.02e-04 | 8.62e-03 | 8.86e-01 | 5.02e-03 |
| RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 125 | 2.47e-45 | 4.77e-43 | 0.916 | 0.4660 | 0.49700 | -0.4330 | -0.24100 | -0.35900 | 2.19e-19 | 7.83e-22 | 5.89e-17 | 3.19e-06 | 4.44e-12 |
| ASPARTATE AND ASPARAGINE METABOLISM | 10 | 1.05e-03 | 5.25e-03 | 0.897 | -0.3790 | 0.53500 | -0.1920 | 0.42600 | -0.39500 | 3.81e-02 | 3.38e-03 | 2.94e-01 | 1.97e-02 | 3.04e-02 |
| SELENOAMINO ACID METABOLISM | 107 | 4.03e-41 | 5.19e-39 | 0.895 | 0.5890 | 0.41000 | -0.4930 | -0.20600 | -0.02890 | 5.63e-26 | 2.40e-13 | 1.31e-18 | 2.43e-04 | 6.06e-01 |
| REGULATION OF RUNX1 EXPRESSION AND ACTIVITY | 17 | 4.88e-04 | 2.66e-03 | 0.873 | 0.0136 | -0.38900 | 0.4430 | -0.21300 | 0.60700 | 9.23e-01 | 5.44e-03 | 1.56e-03 | 1.29e-01 | 1.48e-05 |
| SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES | 29 | 4.47e-06 | 4.47e-05 | 0.851 | 0.2190 | 0.48600 | -0.4950 | 0.10900 | -0.42800 | 4.09e-02 | 5.85e-06 | 3.97e-06 | 3.09e-01 | 6.64e-05 |
| CITRIC ACID CYCLE TCA CYCLE | 22 | 2.56e-05 | 2.17e-04 | 0.850 | 0.0601 | 0.50200 | -0.3270 | 0.48300 | -0.35800 | 6.26e-01 | 4.66e-05 | 7.95e-03 | 8.90e-05 | 3.64e-03 |
| YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 10 | 2.71e-03 | 1.14e-02 | 0.842 | 0.6410 | 0.09850 | 0.2450 | 0.02910 | 0.47800 | 4.50e-04 | 5.90e-01 | 1.80e-01 | 8.73e-01 | 8.87e-03 |
| CRISTAE FORMATION | 31 | 5.06e-08 | 7.33e-07 | 0.841 | 0.3860 | 0.42300 | -0.4350 | -0.16000 | -0.40600 | 1.97e-04 | 4.59e-05 | 2.74e-05 | 1.23e-01 | 9.30e-05 |
| NONSENSE MEDIATED DECAY NMD | 109 | 1.64e-37 | 1.58e-35 | 0.831 | 0.5290 | 0.36400 | -0.4410 | -0.28900 | -0.00929 | 1.31e-21 | 5.21e-11 | 1.89e-15 | 1.96e-07 | 8.67e-01 |
| TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS | 15 | 1.58e-05 | 1.42e-04 | 0.820 | 0.3650 | 0.47800 | 0.0412 | 0.35600 | 0.42600 | 1.43e-02 | 1.35e-03 | 7.82e-01 | 1.70e-02 | 4.27e-03 |
| SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | 20 | 2.77e-04 | 1.63e-03 | 0.817 | 0.0615 | 0.52900 | -0.3600 | 0.39900 | -0.30700 | 6.34e-01 | 4.21e-05 | 5.33e-03 | 1.99e-03 | 1.74e-02 |
| MITOCHONDRIAL TRANSLATION | 93 | 2.05e-25 | 1.48e-23 | 0.815 | 0.3630 | 0.36500 | -0.4180 | -0.20700 | -0.42700 | 1.48e-09 | 1.18e-09 | 3.34e-12 | 5.55e-04 | 1.16e-12 |
| BRANCHED CHAIN AMINO ACID CATABOLISM | 21 | 3.85e-05 | 3.10e-04 | 0.809 | 0.4110 | 0.40500 | -0.2790 | 0.44300 | -0.22000 | 1.12e-03 | 1.33e-03 | 2.71e-02 | 4.37e-04 | 8.07e-02 |
| ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM | 12 | 1.97e-03 | 8.56e-03 | 0.804 | 0.4120 | 0.46600 | -0.0991 | 0.46900 | 0.16900 | 1.34e-02 | 5.22e-03 | 5.52e-01 | 4.87e-03 | 3.12e-01 |
| CD28 DEPENDENT VAV1 PATHWAY | 10 | 3.58e-02 | 8.61e-02 | 0.783 | 0.1440 | 0.40000 | -0.4980 | 0.34600 | -0.25200 | 4.29e-01 | 2.84e-02 | 6.38e-03 | 5.79e-02 | 1.67e-01 |
| CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 46 | 8.14e-10 | 1.93e-08 | 0.783 | 0.4190 | 0.38000 | -0.4580 | -0.01820 | -0.28700 | 8.57e-07 | 8.36e-06 | 7.51e-08 | 8.31e-01 | 7.68e-04 |
| ADENYLATE CYCLASE ACTIVATING PATHWAY | 10 | 2.23e-02 | 5.93e-02 | 0.781 | -0.2300 | -0.14300 | 0.5090 | 0.21500 | 0.48100 | 2.08e-01 | 4.33e-01 | 5.29e-03 | 2.38e-01 | 8.44e-03 |
| THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 172 | 2.98e-39 | 3.14e-37 | 0.780 | 0.3370 | 0.46300 | -0.4040 | -0.09090 | -0.33100 | 2.52e-14 | 1.12e-25 | 6.74e-20 | 4.00e-02 | 7.28e-14 |
| ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 | 19 | 1.23e-04 | 8.42e-04 | 0.780 | 0.3350 | 0.53600 | -0.4500 | 0.07930 | -0.01710 | 1.16e-02 | 5.26e-05 | 6.85e-04 | 5.50e-01 | 8.97e-01 |
| REGULATION OF EXPRESSION OF SLITS AND ROBOS | 160 | 2.36e-44 | 3.42e-42 | 0.777 | 0.4750 | 0.36200 | -0.4410 | -0.21200 | -0.08640 | 3.04e-25 | 2.67e-15 | 6.67e-22 | 3.65e-06 | 5.96e-02 |
| CRMPS IN SEMA3A SIGNALING | 16 | 6.18e-03 | 2.13e-02 | 0.774 | -0.1260 | -0.51500 | 0.4850 | -0.09840 | 0.26900 | 3.84e-01 | 3.57e-04 | 7.90e-04 | 4.96e-01 | 6.23e-02 |
| BLOOD GROUP SYSTEMS BIOSYNTHESIS | 12 | 1.14e-02 | 3.48e-02 | 0.766 | -0.0543 | 0.51700 | -0.1980 | 0.41800 | -0.32100 | 7.45e-01 | 1.94e-03 | 2.35e-01 | 1.21e-02 | 5.44e-02 |
| INCRETIN SYNTHESIS SECRETION AND INACTIVATION | 13 | 1.09e-03 | 5.40e-03 | 0.763 | 0.2880 | 0.27100 | -0.6400 | -0.03370 | -0.12500 | 7.24e-02 | 9.07e-02 | 6.45e-05 | 8.33e-01 | 4.34e-01 |
| SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 | 12 | 3.16e-03 | 1.28e-02 | 0.760 | 0.2540 | 0.21300 | -0.6470 | -0.05050 | -0.21500 | 1.27e-01 | 2.01e-01 | 1.05e-04 | 7.62e-01 | 1.98e-01 |
| RHOBTB3 ATPASE CYCLE | 10 | 3.15e-02 | 7.77e-02 | 0.757 | -0.0796 | 0.47800 | -0.3210 | 0.44600 | -0.19100 | 6.63e-01 | 8.88e-03 | 7.92e-02 | 1.46e-02 | 2.95e-01 |
| PROTEIN METHYLATION | 17 | 5.45e-03 | 1.95e-02 | 0.754 | 0.2950 | 0.44400 | -0.4660 | 0.12900 | -0.22500 | 3.52e-02 | 1.53e-03 | 8.69e-04 | 3.55e-01 | 1.09e-01 |
| GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION | 31 | 7.72e-06 | 7.23e-05 | 0.747 | 0.2230 | 0.30300 | -0.5490 | -0.08300 | -0.32900 | 3.19e-02 | 3.48e-03 | 1.19e-07 | 4.24e-01 | 1.54e-03 |
| SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | 12 | 6.57e-03 | 2.24e-02 | 0.741 | 0.0634 | 0.46600 | -0.5230 | 0.21500 | -0.08530 | 7.04e-01 | 5.18e-03 | 1.70e-03 | 1.97e-01 | 6.09e-01 |
| METABOLISM OF POLYAMINES | 57 | 3.27e-10 | 9.02e-09 | 0.738 | 0.3540 | 0.39100 | -0.4290 | 0.03830 | -0.28500 | 3.80e-06 | 3.24e-07 | 2.09e-08 | 6.17e-01 | 2.00e-04 |
| SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | 12 | 4.36e-03 | 1.63e-02 | 0.738 | 0.4330 | 0.44300 | 0.0929 | 0.35500 | 0.16100 | 9.37e-03 | 7.82e-03 | 5.77e-01 | 3.33e-02 | 3.34e-01 |
| NEGATIVE REGULATION OF NOTCH4 SIGNALING | 54 | 7.18e-10 | 1.83e-08 | 0.736 | 0.3490 | 0.37300 | -0.4420 | -0.04600 | -0.29100 | 9.42e-06 | 2.14e-06 | 1.96e-08 | 5.59e-01 | 2.19e-04 |
| TRANSLATION | 286 | 5.56e-62 | 6.46e-59 | 0.733 | 0.4160 | 0.37200 | -0.4190 | -0.11600 | -0.19300 | 1.12e-33 | 2.83e-27 | 3.35e-34 | 7.69e-04 | 2.01e-08 |
| AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA | 53 | 7.28e-10 | 1.83e-08 | 0.730 | 0.3660 | 0.35700 | -0.4340 | -0.08530 | -0.27400 | 4.10e-06 | 6.84e-06 | 4.63e-08 | 2.83e-01 | 5.57e-04 |
| PHASE 2 PLATEAU PHASE | 10 | 2.53e-02 | 6.56e-02 | 0.726 | -0.1630 | -0.09540 | 0.3960 | -0.06820 | 0.57400 | 3.73e-01 | 6.02e-01 | 3.00e-02 | 7.09e-01 | 1.66e-03 |
| APOPTOSIS INDUCED DNA FRAGMENTATION | 10 | 3.18e-02 | 7.81e-02 | 0.716 | -0.2360 | 0.00964 | -0.4770 | -0.29000 | -0.38300 | 1.96e-01 | 9.58e-01 | 9.07e-03 | 1.13e-01 | 3.62e-02 |
| DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS | 58 | 3.21e-10 | 9.02e-09 | 0.716 | 0.3490 | 0.38900 | -0.4430 | 0.04860 | -0.20400 | 4.18e-06 | 3.09e-07 | 5.43e-09 | 5.22e-01 | 7.20e-03 |
| INTERACTION BETWEEN L1 AND ANKYRINS | 27 | 3.23e-04 | 1.86e-03 | 0.712 | -0.2910 | -0.34800 | 0.3940 | -0.12000 | 0.36200 | 8.82e-03 | 1.73e-03 | 3.90e-04 | 2.80e-01 | 1.14e-03 |
| ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS | 10 | 1.39e-02 | 4.06e-02 | 0.709 | -0.5540 | -0.24600 | -0.0696 | 0.15500 | -0.32700 | 2.43e-03 | 1.77e-01 | 7.03e-01 | 3.95e-01 | 7.37e-02 |
| SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX | 13 | 1.08e-02 | 3.33e-02 | 0.707 | 0.4770 | 0.42300 | -0.3000 | -0.00582 | 0.05740 | 2.92e-03 | 8.26e-03 | 6.14e-02 | 9.71e-01 | 7.20e-01 |
| GLYCOGEN SYNTHESIS | 14 | 1.76e-02 | 4.96e-02 | 0.706 | 0.1980 | 0.46200 | -0.4220 | 0.23400 | -0.11600 | 1.99e-01 | 2.78e-03 | 6.23e-03 | 1.30e-01 | 4.51e-01 |
Results (complete table)
Click HERE to show results for all gene sets
| set | setSize | pMANOVA | p.adjustMANOVA | s.dist | s.hyp | s.amy | s.hip | s.pag | s.ni | p.hyp | p.amy | p.hip | p.pag | p.ni |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EUKARYOTIC TRANSLATION ELONGATION | 87 | 2.18e-55 | 1.27e-52 | 1.1300 | 7.59e-01 | 0.506000 | -0.568000 | -0.342000 | -0.005910 | 1.61e-34 | 3.15e-16 | 5.18e-20 | 3.61e-08 | 9.24e-01 |
| SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 106 | 1.50e-53 | 5.81e-51 | 1.0200 | 6.79e-01 | 0.482000 | -0.536000 | -0.252000 | -0.029700 | 1.19e-33 | 9.62e-18 | 1.41e-21 | 7.51e-06 | 5.97e-01 |
| RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY | 94 | 2.62e-48 | 6.08e-46 | 1.0200 | 6.58e-01 | 0.459000 | -0.530000 | -0.341000 | -0.037800 | 2.50e-28 | 1.41e-14 | 6.09e-19 | 1.17e-08 | 5.26e-01 |
| COMPLEX I BIOGENESIS | 56 | 6.50e-25 | 4.43e-23 | 1.0200 | 5.24e-01 | 0.529000 | -0.490000 | -0.322000 | -0.364000 | 1.16e-11 | 7.71e-12 | 2.29e-10 | 3.03e-05 | 2.48e-06 |
| EUKARYOTIC TRANSLATION INITIATION | 114 | 1.10e-51 | 3.18e-49 | 0.9870 | 6.32e-01 | 0.466000 | -0.544000 | -0.232000 | -0.082400 | 1.68e-31 | 8.59e-18 | 1.05e-23 | 1.85e-05 | 1.29e-01 |
| FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | 18 | 7.33e-07 | 8.59e-06 | 0.9590 | 5.45e-01 | 0.476000 | -0.419000 | -0.266000 | -0.388000 | 6.34e-05 | 4.74e-04 | 2.10e-03 | 5.07e-02 | 4.38e-03 |
| ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 59 | 3.50e-22 | 2.03e-20 | 0.9460 | 5.88e-01 | 0.472000 | -0.548000 | -0.101000 | -0.130000 | 5.30e-15 | 3.69e-10 | 3.40e-13 | 1.79e-01 | 8.38e-02 |
| RESPIRATORY ELECTRON TRANSPORT | 102 | 2.82e-39 | 3.14e-37 | 0.9440 | 4.63e-01 | 0.504000 | -0.453000 | -0.271000 | -0.378000 | 6.25e-16 | 1.31e-18 | 2.63e-15 | 2.28e-06 | 4.50e-11 |
| REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO | 10 | 1.15e-03 | 5.67e-03 | 0.9410 | -6.28e-01 | -0.311000 | 0.445000 | 0.098600 | 0.432000 | 5.85e-04 | 8.86e-02 | 1.48e-02 | 5.89e-01 | 1.81e-02 |
| TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | 11 | 3.27e-03 | 1.31e-02 | 0.9350 | 8.64e-02 | 0.647000 | -0.457000 | 0.025000 | -0.489000 | 6.20e-01 | 2.02e-04 | 8.62e-03 | 8.86e-01 | 5.02e-03 |
| RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | 125 | 2.47e-45 | 4.77e-43 | 0.9160 | 4.66e-01 | 0.497000 | -0.433000 | -0.241000 | -0.359000 | 2.19e-19 | 7.83e-22 | 5.89e-17 | 3.19e-06 | 4.44e-12 |
| ASPARTATE AND ASPARAGINE METABOLISM | 10 | 1.05e-03 | 5.25e-03 | 0.8970 | -3.79e-01 | 0.535000 | -0.192000 | 0.426000 | -0.395000 | 3.81e-02 | 3.38e-03 | 2.94e-01 | 1.97e-02 | 3.04e-02 |
| SELENOAMINO ACID METABOLISM | 107 | 4.03e-41 | 5.19e-39 | 0.8950 | 5.89e-01 | 0.410000 | -0.493000 | -0.206000 | -0.028900 | 5.63e-26 | 2.40e-13 | 1.31e-18 | 2.43e-04 | 6.06e-01 |
| REGULATION OF RUNX1 EXPRESSION AND ACTIVITY | 17 | 4.88e-04 | 2.66e-03 | 0.8730 | 1.36e-02 | -0.389000 | 0.443000 | -0.213000 | 0.607000 | 9.23e-01 | 5.44e-03 | 1.56e-03 | 1.29e-01 | 1.48e-05 |
| SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES | 29 | 4.47e-06 | 4.47e-05 | 0.8510 | 2.19e-01 | 0.486000 | -0.495000 | 0.109000 | -0.428000 | 4.09e-02 | 5.85e-06 | 3.97e-06 | 3.09e-01 | 6.64e-05 |
| CITRIC ACID CYCLE TCA CYCLE | 22 | 2.56e-05 | 2.17e-04 | 0.8500 | 6.01e-02 | 0.502000 | -0.327000 | 0.483000 | -0.358000 | 6.26e-01 | 4.66e-05 | 7.95e-03 | 8.90e-05 | 3.64e-03 |
| YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | 10 | 2.71e-03 | 1.14e-02 | 0.8420 | 6.41e-01 | 0.098500 | 0.245000 | 0.029100 | 0.478000 | 4.50e-04 | 5.90e-01 | 1.80e-01 | 8.73e-01 | 8.87e-03 |
| CRISTAE FORMATION | 31 | 5.06e-08 | 7.33e-07 | 0.8410 | 3.86e-01 | 0.423000 | -0.435000 | -0.160000 | -0.406000 | 1.97e-04 | 4.59e-05 | 2.74e-05 | 1.23e-01 | 9.30e-05 |
| NONSENSE MEDIATED DECAY NMD | 109 | 1.64e-37 | 1.58e-35 | 0.8310 | 5.29e-01 | 0.364000 | -0.441000 | -0.289000 | -0.009290 | 1.31e-21 | 5.21e-11 | 1.89e-15 | 1.96e-07 | 8.67e-01 |
| TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS | 15 | 1.58e-05 | 1.42e-04 | 0.8200 | 3.65e-01 | 0.478000 | 0.041200 | 0.356000 | 0.426000 | 1.43e-02 | 1.35e-03 | 7.82e-01 | 1.70e-02 | 4.27e-03 |
| SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | 20 | 2.77e-04 | 1.63e-03 | 0.8170 | 6.15e-02 | 0.529000 | -0.360000 | 0.399000 | -0.307000 | 6.34e-01 | 4.21e-05 | 5.33e-03 | 1.99e-03 | 1.74e-02 |
| MITOCHONDRIAL TRANSLATION | 93 | 2.05e-25 | 1.48e-23 | 0.8150 | 3.63e-01 | 0.365000 | -0.418000 | -0.207000 | -0.427000 | 1.48e-09 | 1.18e-09 | 3.34e-12 | 5.55e-04 | 1.16e-12 |
| BRANCHED CHAIN AMINO ACID CATABOLISM | 21 | 3.85e-05 | 3.10e-04 | 0.8090 | 4.11e-01 | 0.405000 | -0.279000 | 0.443000 | -0.220000 | 1.12e-03 | 1.33e-03 | 2.71e-02 | 4.37e-04 | 8.07e-02 |
| ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM | 12 | 1.97e-03 | 8.56e-03 | 0.8040 | 4.12e-01 | 0.466000 | -0.099100 | 0.469000 | 0.169000 | 1.34e-02 | 5.22e-03 | 5.52e-01 | 4.87e-03 | 3.12e-01 |
| CD28 DEPENDENT VAV1 PATHWAY | 10 | 3.58e-02 | 8.61e-02 | 0.7830 | 1.44e-01 | 0.400000 | -0.498000 | 0.346000 | -0.252000 | 4.29e-01 | 2.84e-02 | 6.38e-03 | 5.79e-02 | 1.67e-01 |
| CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 46 | 8.14e-10 | 1.93e-08 | 0.7830 | 4.19e-01 | 0.380000 | -0.458000 | -0.018200 | -0.287000 | 8.57e-07 | 8.36e-06 | 7.51e-08 | 8.31e-01 | 7.68e-04 |
| ADENYLATE CYCLASE ACTIVATING PATHWAY | 10 | 2.23e-02 | 5.93e-02 | 0.7810 | -2.30e-01 | -0.143000 | 0.509000 | 0.215000 | 0.481000 | 2.08e-01 | 4.33e-01 | 5.29e-03 | 2.38e-01 | 8.44e-03 |
| THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 172 | 2.98e-39 | 3.14e-37 | 0.7800 | 3.37e-01 | 0.463000 | -0.404000 | -0.090900 | -0.331000 | 2.52e-14 | 1.12e-25 | 6.74e-20 | 4.00e-02 | 7.28e-14 |
| ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 | 19 | 1.23e-04 | 8.42e-04 | 0.7800 | 3.35e-01 | 0.536000 | -0.450000 | 0.079300 | -0.017100 | 1.16e-02 | 5.26e-05 | 6.85e-04 | 5.50e-01 | 8.97e-01 |
| REGULATION OF EXPRESSION OF SLITS AND ROBOS | 160 | 2.36e-44 | 3.42e-42 | 0.7770 | 4.75e-01 | 0.362000 | -0.441000 | -0.212000 | -0.086400 | 3.04e-25 | 2.67e-15 | 6.67e-22 | 3.65e-06 | 5.96e-02 |
| CRMPS IN SEMA3A SIGNALING | 16 | 6.18e-03 | 2.13e-02 | 0.7740 | -1.26e-01 | -0.515000 | 0.485000 | -0.098400 | 0.269000 | 3.84e-01 | 3.57e-04 | 7.90e-04 | 4.96e-01 | 6.23e-02 |
| BLOOD GROUP SYSTEMS BIOSYNTHESIS | 12 | 1.14e-02 | 3.48e-02 | 0.7660 | -5.43e-02 | 0.517000 | -0.198000 | 0.418000 | -0.321000 | 7.45e-01 | 1.94e-03 | 2.35e-01 | 1.21e-02 | 5.44e-02 |
| INCRETIN SYNTHESIS SECRETION AND INACTIVATION | 13 | 1.09e-03 | 5.40e-03 | 0.7630 | 2.88e-01 | 0.271000 | -0.640000 | -0.033700 | -0.125000 | 7.24e-02 | 9.07e-02 | 6.45e-05 | 8.33e-01 | 4.34e-01 |
| SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 | 12 | 3.16e-03 | 1.28e-02 | 0.7600 | 2.54e-01 | 0.213000 | -0.647000 | -0.050500 | -0.215000 | 1.27e-01 | 2.01e-01 | 1.05e-04 | 7.62e-01 | 1.98e-01 |
| RHOBTB3 ATPASE CYCLE | 10 | 3.15e-02 | 7.77e-02 | 0.7570 | -7.96e-02 | 0.478000 | -0.321000 | 0.446000 | -0.191000 | 6.63e-01 | 8.88e-03 | 7.92e-02 | 1.46e-02 | 2.95e-01 |
| PROTEIN METHYLATION | 17 | 5.45e-03 | 1.95e-02 | 0.7540 | 2.95e-01 | 0.444000 | -0.466000 | 0.129000 | -0.225000 | 3.52e-02 | 1.53e-03 | 8.69e-04 | 3.55e-01 | 1.09e-01 |
| GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION | 31 | 7.72e-06 | 7.23e-05 | 0.7470 | 2.23e-01 | 0.303000 | -0.549000 | -0.083000 | -0.329000 | 3.19e-02 | 3.48e-03 | 1.19e-07 | 4.24e-01 | 1.54e-03 |
| SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | 12 | 6.57e-03 | 2.24e-02 | 0.7410 | 6.34e-02 | 0.466000 | -0.523000 | 0.215000 | -0.085300 | 7.04e-01 | 5.18e-03 | 1.70e-03 | 1.97e-01 | 6.09e-01 |
| METABOLISM OF POLYAMINES | 57 | 3.27e-10 | 9.02e-09 | 0.7380 | 3.54e-01 | 0.391000 | -0.429000 | 0.038300 | -0.285000 | 3.80e-06 | 3.24e-07 | 2.09e-08 | 6.17e-01 | 2.00e-04 |
| SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | 12 | 4.36e-03 | 1.63e-02 | 0.7380 | 4.33e-01 | 0.443000 | 0.092900 | 0.355000 | 0.161000 | 9.37e-03 | 7.82e-03 | 5.77e-01 | 3.33e-02 | 3.34e-01 |
| NEGATIVE REGULATION OF NOTCH4 SIGNALING | 54 | 7.18e-10 | 1.83e-08 | 0.7360 | 3.49e-01 | 0.373000 | -0.442000 | -0.046000 | -0.291000 | 9.42e-06 | 2.14e-06 | 1.96e-08 | 5.59e-01 | 2.19e-04 |
| TRANSLATION | 286 | 5.56e-62 | 6.46e-59 | 0.7330 | 4.16e-01 | 0.372000 | -0.419000 | -0.116000 | -0.193000 | 1.12e-33 | 2.83e-27 | 3.35e-34 | 7.69e-04 | 2.01e-08 |
| AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA | 53 | 7.28e-10 | 1.83e-08 | 0.7300 | 3.66e-01 | 0.357000 | -0.434000 | -0.085300 | -0.274000 | 4.10e-06 | 6.84e-06 | 4.63e-08 | 2.83e-01 | 5.57e-04 |
| PHASE 2 PLATEAU PHASE | 10 | 2.53e-02 | 6.56e-02 | 0.7260 | -1.63e-01 | -0.095400 | 0.396000 | -0.068200 | 0.574000 | 3.73e-01 | 6.02e-01 | 3.00e-02 | 7.09e-01 | 1.66e-03 |
| APOPTOSIS INDUCED DNA FRAGMENTATION | 10 | 3.18e-02 | 7.81e-02 | 0.7160 | -2.36e-01 | 0.009640 | -0.477000 | -0.290000 | -0.383000 | 1.96e-01 | 9.58e-01 | 9.07e-03 | 1.13e-01 | 3.62e-02 |
| DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS | 58 | 3.21e-10 | 9.02e-09 | 0.7160 | 3.49e-01 | 0.389000 | -0.443000 | 0.048600 | -0.204000 | 4.18e-06 | 3.09e-07 | 5.43e-09 | 5.22e-01 | 7.20e-03 |
| INTERACTION BETWEEN L1 AND ANKYRINS | 27 | 3.23e-04 | 1.86e-03 | 0.7120 | -2.91e-01 | -0.348000 | 0.394000 | -0.120000 | 0.362000 | 8.82e-03 | 1.73e-03 | 3.90e-04 | 2.80e-01 | 1.14e-03 |
| ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS | 10 | 1.39e-02 | 4.06e-02 | 0.7090 | -5.54e-01 | -0.246000 | -0.069600 | 0.155000 | -0.327000 | 2.43e-03 | 1.77e-01 | 7.03e-01 | 3.95e-01 | 7.37e-02 |
| SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX | 13 | 1.08e-02 | 3.33e-02 | 0.7070 | 4.77e-01 | 0.423000 | -0.300000 | -0.005820 | 0.057400 | 2.92e-03 | 8.26e-03 | 6.14e-02 | 9.71e-01 | 7.20e-01 |
| GLYCOGEN SYNTHESIS | 14 | 1.76e-02 | 4.96e-02 | 0.7060 | 1.98e-01 | 0.462000 | -0.422000 | 0.234000 | -0.116000 | 1.99e-01 | 2.78e-03 | 6.23e-03 | 1.30e-01 | 4.51e-01 |
| PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | 16 | 9.00e-04 | 4.54e-03 | 0.7060 | 3.36e-01 | 0.465000 | -0.391000 | -0.106000 | 0.074800 | 2.01e-02 | 1.28e-03 | 6.73e-03 | 4.65e-01 | 6.04e-01 |
| STABILIZATION OF P53 | 54 | 3.46e-09 | 7.05e-08 | 0.6990 | 3.67e-01 | 0.339000 | -0.407000 | -0.050800 | -0.267000 | 3.05e-06 | 1.68e-05 | 2.29e-07 | 5.19e-01 | 6.94e-04 |
| TRIGLYCERIDE CATABOLISM | 14 | 8.26e-03 | 2.71e-02 | 0.6990 | 1.34e-01 | 0.519000 | -0.436000 | 0.085400 | -0.061200 | 3.84e-01 | 7.76e-04 | 4.69e-03 | 5.80e-01 | 6.92e-01 |
| SCF SKP2 MEDIATED DEGRADATION OF P27 P21 | 59 | 7.41e-10 | 1.83e-08 | 0.6990 | 3.26e-01 | 0.324000 | -0.432000 | -0.058700 | -0.294000 | 1.52e-05 | 1.65e-05 | 9.20e-09 | 4.36e-01 | 9.30e-05 |
| DETOXIFICATION OF REACTIVE OXYGEN SPECIES | 31 | 6.22e-06 | 6.01e-05 | 0.6980 | 4.05e-01 | 0.404000 | -0.363000 | -0.140000 | -0.089100 | 9.42e-05 | 9.96e-05 | 4.64e-04 | 1.76e-01 | 3.91e-01 |
| NUCLEOTIDE LIKE PURINERGIC RECEPTORS | 13 | 9.00e-03 | 2.89e-02 | 0.6950 | 2.86e-01 | 0.547000 | -0.059800 | 0.313000 | -0.014800 | 7.46e-02 | 6.38e-04 | 7.09e-01 | 5.07e-02 | 9.26e-01 |
| PINK1 PRKN MEDIATED MITOPHAGY | 22 | 1.26e-03 | 6.08e-03 | 0.6920 | 2.75e-01 | 0.511000 | -0.344000 | 0.031300 | -0.149000 | 2.56e-02 | 3.28e-05 | 5.27e-03 | 7.99e-01 | 2.26e-01 |
| G BETA GAMMA SIGNALLING THROUGH CDC42 | 18 | 4.23e-03 | 1.60e-02 | 0.6880 | 3.13e-01 | 0.450000 | -0.408000 | -0.001780 | -0.080000 | 2.15e-02 | 9.55e-04 | 2.70e-03 | 9.90e-01 | 5.57e-01 |
| NCAM1 INTERACTIONS | 38 | 1.05e-07 | 1.35e-06 | 0.6850 | -2.72e-01 | -0.280000 | 0.393000 | -0.360000 | 0.180000 | 3.68e-03 | 2.85e-03 | 2.78e-05 | 1.22e-04 | 5.46e-02 |
| CELLULAR RESPONSE TO STARVATION | 145 | 1.21e-30 | 1.08e-28 | 0.6820 | 4.21e-01 | 0.340000 | -0.373000 | -0.174000 | -0.054600 | 2.23e-18 | 1.55e-12 | 9.71e-15 | 2.91e-04 | 2.57e-01 |
| SEROTONIN NEUROTRANSMITTER RELEASE CYCLE | 18 | 1.64e-03 | 7.39e-03 | 0.6750 | -5.08e-01 | -0.290000 | 0.211000 | -0.057900 | 0.256000 | 1.91e-04 | 3.30e-02 | 1.22e-01 | 6.71e-01 | 5.99e-02 |
| FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | 19 | 5.19e-03 | 1.87e-02 | 0.6720 | 1.99e-01 | 0.259000 | -0.327000 | 0.284000 | -0.397000 | 1.32e-01 | 5.06e-02 | 1.36e-02 | 3.23e-02 | 2.77e-03 |
| NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 11 | 8.19e-02 | 1.62e-01 | 0.6720 | -1.05e-01 | -0.318000 | 0.303000 | -0.021900 | 0.497000 | 5.46e-01 | 6.82e-02 | 8.20e-02 | 9.00e-01 | 4.30e-03 |
| LGI ADAM INTERACTIONS | 14 | 1.28e-02 | 3.80e-02 | 0.6720 | -3.77e-01 | -0.227000 | 0.280000 | -0.242000 | 0.347000 | 1.47e-02 | 1.41e-01 | 6.94e-02 | 1.17e-01 | 2.44e-02 |
| CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT | 20 | 9.36e-03 | 2.98e-02 | 0.6670 | 1.03e-02 | 0.447000 | -0.311000 | 0.193000 | -0.332000 | 9.36e-01 | 5.33e-04 | 1.60e-02 | 1.36e-01 | 1.01e-02 |
| REGULATION OF HMOX1 EXPRESSION AND ACTIVITY | 63 | 4.72e-09 | 8.83e-08 | 0.6670 | 3.13e-01 | 0.351000 | -0.380000 | 0.048800 | -0.276000 | 1.71e-05 | 1.47e-06 | 1.78e-07 | 5.03e-01 | 1.54e-04 |
| MITOCHONDRIAL PROTEIN IMPORT | 63 | 2.09e-09 | 4.64e-08 | 0.6650 | 2.78e-01 | 0.338000 | -0.352000 | -0.012100 | -0.356000 | 1.35e-04 | 3.61e-06 | 1.38e-06 | 8.68e-01 | 1.01e-06 |
| COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING | 26 | 1.33e-03 | 6.35e-03 | 0.6630 | 2.23e-01 | 0.271000 | -0.411000 | 0.103000 | -0.371000 | 4.94e-02 | 1.68e-02 | 2.86e-04 | 3.65e-01 | 1.07e-03 |
| REGULATION OF RUNX3 EXPRESSION AND ACTIVITY | 53 | 6.39e-08 | 8.95e-07 | 0.6620 | 3.32e-01 | 0.359000 | -0.384000 | -0.058300 | -0.220000 | 2.96e-05 | 6.06e-06 | 1.30e-06 | 4.63e-01 | 5.60e-03 |
| CALNEXIN CALRETICULIN CYCLE | 26 | 1.97e-05 | 1.73e-04 | 0.6570 | 1.04e-01 | 0.398000 | -0.236000 | 0.453000 | 0.044800 | 3.59e-01 | 4.39e-04 | 3.75e-02 | 6.41e-05 | 6.93e-01 |
| MITOCHONDRIAL FATTY ACID BETA OXIDATION | 33 | 4.10e-05 | 3.27e-04 | 0.6570 | 4.09e-01 | 0.296000 | -0.369000 | 0.028100 | -0.198000 | 4.81e-05 | 3.21e-03 | 2.46e-04 | 7.80e-01 | 4.85e-02 |
| PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | 12 | 2.79e-02 | 7.03e-02 | 0.6550 | -1.08e-01 | 0.417000 | -0.155000 | 0.457000 | -0.105000 | 5.19e-01 | 1.24e-02 | 3.51e-01 | 6.13e-03 | 5.30e-01 |
| DEGRADATION OF DVL | 55 | 3.02e-08 | 4.68e-07 | 0.6550 | 3.37e-01 | 0.297000 | -0.382000 | -0.060400 | -0.279000 | 1.58e-05 | 1.39e-04 | 9.48e-07 | 4.39e-01 | 3.43e-04 |
| CELLULAR RESPONSE TO HYPOXIA | 71 | 5.13e-11 | 1.61e-09 | 0.6540 | 3.68e-01 | 0.317000 | -0.348000 | -0.047200 | -0.263000 | 8.50e-08 | 4.01e-06 | 3.90e-07 | 4.92e-01 | 1.25e-04 |
| PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 51 | 2.81e-07 | 3.51e-06 | 0.6540 | 2.47e-03 | 0.391000 | -0.336000 | 0.310000 | -0.257000 | 9.76e-01 | 1.39e-06 | 3.24e-05 | 1.29e-04 | 1.50e-03 |
| NOTCH HLH TRANSCRIPTION PATHWAY | 28 | 1.48e-03 | 6.82e-03 | 0.6530 | -1.71e-02 | -0.271000 | 0.395000 | -0.044000 | 0.441000 | 8.76e-01 | 1.30e-02 | 2.96e-04 | 6.87e-01 | 5.47e-05 |
| ANTIGEN PROCESSING CROSS PRESENTATION | 93 | 1.31e-15 | 5.61e-14 | 0.6520 | 4.14e-01 | 0.313000 | -0.366000 | -0.051000 | -0.142000 | 5.49e-12 | 1.83e-07 | 1.09e-09 | 3.96e-01 | 1.83e-02 |
| ACTIVATION OF SMO | 16 | 1.34e-02 | 3.94e-02 | 0.6520 | 8.88e-02 | -0.203000 | 0.404000 | 0.284000 | 0.364000 | 5.39e-01 | 1.59e-01 | 5.18e-03 | 4.91e-02 | 1.18e-02 |
| DEGRADATION OF AXIN | 53 | 1.35e-07 | 1.72e-06 | 0.6520 | 3.42e-01 | 0.333000 | -0.374000 | -0.018800 | -0.239000 | 1.70e-05 | 2.69e-05 | 2.46e-06 | 8.13e-01 | 2.67e-03 |
| FATTY ACYL COA BIOSYNTHESIS | 32 | 5.27e-05 | 3.95e-04 | 0.6520 | 5.51e-02 | 0.470000 | -0.268000 | 0.332000 | -0.135000 | 5.89e-01 | 4.18e-06 | 8.73e-03 | 1.14e-03 | 1.86e-01 |
| GLUTATHIONE CONJUGATION | 29 | 4.22e-05 | 3.31e-04 | 0.6500 | 4.38e-01 | 0.382000 | -0.167000 | 0.077900 | -0.227000 | 4.53e-05 | 3.73e-04 | 1.19e-01 | 4.68e-01 | 3.47e-02 |
| SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | 11 | 1.56e-02 | 4.50e-02 | 0.6490 | -3.65e-01 | 0.040500 | 0.180000 | 0.469000 | -0.185000 | 3.60e-02 | 8.16e-01 | 3.02e-01 | 7.03e-03 | 2.88e-01 |
| DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING | 59 | 1.18e-08 | 1.99e-07 | 0.6470 | 3.47e-01 | 0.329000 | -0.341000 | -0.039900 | -0.269000 | 3.94e-06 | 1.25e-05 | 6.10e-06 | 5.97e-01 | 3.45e-04 |
| DEGRADATION OF GLI1 BY THE PROTEASOME | 57 | 8.86e-08 | 1.21e-06 | 0.6460 | 3.11e-01 | 0.354000 | -0.365000 | -0.013500 | -0.248000 | 4.83e-05 | 3.74e-06 | 1.94e-06 | 8.60e-01 | 1.23e-03 |
| NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | 11 | 8.82e-04 | 4.49e-03 | 0.6440 | 3.15e-02 | 0.219000 | -0.049200 | 0.290000 | 0.528000 | 8.57e-01 | 2.09e-01 | 7.78e-01 | 9.54e-02 | 2.42e-03 |
| HEDGEHOG LIGAND BIOGENESIS | 61 | 1.16e-08 | 1.99e-07 | 0.6410 | 3.46e-01 | 0.348000 | -0.372000 | 0.062600 | -0.168000 | 3.06e-06 | 2.57e-06 | 5.01e-07 | 3.98e-01 | 2.33e-02 |
| SYNAPTIC ADHESION LIKE MOLECULES | 21 | 1.58e-02 | 4.53e-02 | 0.6380 | -1.83e-01 | -0.315000 | 0.415000 | 0.031900 | 0.317000 | 1.46e-01 | 1.24e-02 | 9.92e-04 | 8.00e-01 | 1.18e-02 |
| MET ACTIVATES RAP1 AND RAC1 | 10 | 1.55e-01 | 2.55e-01 | 0.6370 | -1.62e-02 | 0.322000 | -0.222000 | 0.422000 | -0.273000 | 9.29e-01 | 7.78e-02 | 2.24e-01 | 2.08e-02 | 1.35e-01 |
| RAS PROCESSING | 23 | 4.29e-03 | 1.62e-02 | 0.6360 | 2.70e-01 | 0.464000 | -0.287000 | 0.056700 | -0.177000 | 2.50e-02 | 1.18e-04 | 1.74e-02 | 6.38e-01 | 1.42e-01 |
| ER QUALITY CONTROL COMPARTMENT ERQC | 21 | 3.63e-04 | 2.04e-03 | 0.6350 | 1.65e-02 | 0.399000 | -0.199000 | 0.451000 | 0.038700 | 8.96e-01 | 1.55e-03 | 1.14e-01 | 3.49e-04 | 7.59e-01 |
| P75NTR REGULATES AXONOGENESIS | 10 | 1.03e-01 | 1.90e-01 | 0.6350 | -3.31e-01 | 0.150000 | -0.210000 | 0.219000 | -0.423000 | 6.99e-02 | 4.11e-01 | 2.49e-01 | 2.30e-01 | 2.06e-02 |
| G PROTEIN ACTIVATION | 22 | 3.24e-05 | 2.67e-04 | 0.6330 | 3.91e-01 | 0.307000 | -0.256000 | -0.122000 | 0.270000 | 1.49e-03 | 1.27e-02 | 3.76e-02 | 3.23e-01 | 2.83e-02 |
| REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS | 11 | 1.79e-02 | 5.01e-02 | 0.6320 | -2.87e-01 | 0.078500 | 0.382000 | 0.243000 | 0.326000 | 9.93e-02 | 6.52e-01 | 2.81e-02 | 1.64e-01 | 6.15e-02 |
| COLLAGEN CHAIN TRIMERIZATION | 37 | 2.66e-09 | 5.62e-08 | 0.6310 | -2.07e-01 | -0.348000 | 0.335000 | -0.314000 | -0.155000 | 2.95e-02 | 2.49e-04 | 4.27e-04 | 9.69e-04 | 1.03e-01 |
| INTERLEUKIN 12 SIGNALING | 36 | 1.30e-04 | 8.72e-04 | 0.6310 | 2.32e-01 | 0.276000 | -0.438000 | 0.007830 | -0.275000 | 1.62e-02 | 4.16e-03 | 5.34e-06 | 9.35e-01 | 4.24e-03 |
| INTERLEUKIN 6 SIGNALING | 10 | 1.09e-01 | 2.00e-01 | 0.6290 | 3.04e-01 | -0.029800 | 0.353000 | 0.157000 | 0.391000 | 9.56e-02 | 8.70e-01 | 5.35e-02 | 3.91e-01 | 3.23e-02 |
| METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS | 10 | 1.58e-01 | 2.58e-01 | 0.6260 | 3.19e-01 | 0.452000 | -0.225000 | 0.188000 | -0.024700 | 8.11e-02 | 1.34e-02 | 2.18e-01 | 3.04e-01 | 8.93e-01 |
| ORC1 REMOVAL FROM CHROMATIN | 67 | 1.94e-08 | 3.13e-07 | 0.6240 | 2.42e-01 | 0.291000 | -0.378000 | -0.022000 | -0.320000 | 6.20e-04 | 3.73e-05 | 9.03e-08 | 7.56e-01 | 5.76e-06 |
| THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | 22 | 2.22e-04 | 1.36e-03 | 0.6220 | 3.87e-01 | 0.403000 | -0.182000 | -0.021100 | 0.204000 | 1.69e-03 | 1.06e-03 | 1.39e-01 | 8.64e-01 | 9.82e-02 |
| MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS | 13 | 1.38e-02 | 4.04e-02 | 0.6210 | 1.24e-01 | 0.370000 | -0.231000 | -0.293000 | -0.307000 | 4.40e-01 | 2.10e-02 | 1.49e-01 | 6.76e-02 | 5.51e-02 |
| ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES | 10 | 1.45e-01 | 2.44e-01 | 0.6210 | 3.14e-01 | 0.472000 | -0.144000 | 0.192000 | -0.081700 | 8.58e-02 | 9.82e-03 | 4.29e-01 | 2.93e-01 | 6.55e-01 |
| RUNX3 REGULATES NOTCH SIGNALING | 13 | 8.30e-02 | 1.63e-01 | 0.6210 | -1.18e-01 | -0.166000 | 0.376000 | 0.043400 | 0.448000 | 4.62e-01 | 3.01e-01 | 1.89e-02 | 7.86e-01 | 5.20e-03 |
| PENTOSE PHOSPHATE PATHWAY | 13 | 1.67e-01 | 2.69e-01 | 0.6190 | 4.86e-02 | 0.330000 | -0.351000 | 0.165000 | -0.348000 | 7.62e-01 | 3.91e-02 | 2.83e-02 | 3.02e-01 | 2.99e-02 |
| APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 69 | 8.09e-09 | 1.44e-07 | 0.6180 | 2.86e-01 | 0.283000 | -0.369000 | -0.011700 | -0.288000 | 4.08e-05 | 4.71e-05 | 1.12e-07 | 8.67e-01 | 3.60e-05 |
| SHC MEDIATED CASCADE FGFR4 | 10 | 7.66e-02 | 1.53e-01 | 0.6170 | 1.14e-01 | 0.507000 | -0.294000 | -0.115000 | -0.104000 | 5.34e-01 | 5.49e-03 | 1.08e-01 | 5.28e-01 | 5.69e-01 |
| ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 64 | 8.97e-08 | 1.21e-06 | 0.6160 | 2.44e-01 | 0.290000 | -0.383000 | -0.013200 | -0.299000 | 7.48e-04 | 6.04e-05 | 1.20e-07 | 8.55e-01 | 3.59e-05 |
| INFLUENZA INFECTION | 145 | 9.08e-25 | 5.85e-23 | 0.6150 | 3.64e-01 | 0.298000 | -0.351000 | -0.177000 | -0.059500 | 4.18e-14 | 6.36e-10 | 3.28e-13 | 2.36e-04 | 2.17e-01 |
| FGFR2 LIGAND BINDING AND ACTIVATION | 10 | 6.63e-02 | 1.38e-01 | 0.6140 | 2.07e-02 | 0.298000 | -0.228000 | -0.232000 | -0.427000 | 9.10e-01 | 1.03e-01 | 2.13e-01 | 2.04e-01 | 1.95e-02 |
| THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT | 65 | 4.81e-08 | 7.07e-07 | 0.6110 | 2.56e-01 | 0.297000 | -0.366000 | -0.070100 | -0.283000 | 3.53e-04 | 3.53e-05 | 3.31e-07 | 3.28e-01 | 8.02e-05 |
| N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | 35 | 2.15e-06 | 2.27e-05 | 0.6100 | 1.33e-01 | 0.374000 | -0.239000 | 0.394000 | 0.055200 | 1.73e-01 | 1.30e-04 | 1.45e-02 | 5.59e-05 | 5.72e-01 |
| REGULATION OF MECP2 EXPRESSION AND ACTIVITY | 29 | 4.26e-03 | 1.61e-02 | 0.6100 | -1.42e-01 | -0.327000 | 0.339000 | -0.188000 | 0.309000 | 1.85e-01 | 2.34e-03 | 1.59e-03 | 8.01e-02 | 4.03e-03 |
| SIGNALING BY LEPTIN | 10 | 2.11e-01 | 3.16e-01 | 0.6090 | 9.24e-02 | -0.132000 | 0.427000 | 0.062100 | 0.399000 | 6.13e-01 | 4.69e-01 | 1.95e-02 | 7.34e-01 | 2.90e-02 |
| G1 S DNA DAMAGE CHECKPOINTS | 65 | 2.33e-08 | 3.71e-07 | 0.6080 | 2.94e-01 | 0.277000 | -0.357000 | -0.076400 | -0.272000 | 4.29e-05 | 1.16e-04 | 6.37e-07 | 2.87e-01 | 1.50e-04 |
| METABOLISM OF AMINO ACIDS AND DERIVATIVES | 303 | 1.32e-44 | 2.18e-42 | 0.6080 | 3.71e-01 | 0.367000 | -0.300000 | 0.040800 | -0.079000 | 1.44e-28 | 5.65e-28 | 2.92e-19 | 2.23e-01 | 1.83e-02 |
| DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 78 | 4.26e-09 | 8.09e-08 | 0.6080 | 2.57e-01 | 0.346000 | -0.334000 | 0.034800 | -0.266000 | 8.58e-05 | 1.30e-07 | 3.32e-07 | 5.95e-01 | 5.05e-05 |
| CS DS DEGRADATION | 14 | 1.26e-02 | 3.77e-02 | 0.6060 | 4.05e-01 | 0.261000 | 0.000117 | 0.144000 | 0.338000 | 8.69e-03 | 9.10e-02 | 9.99e-01 | 3.52e-01 | 2.85e-02 |
| DARPP 32 EVENTS | 23 | 2.09e-04 | 1.31e-03 | 0.6060 | -2.66e-01 | 0.437000 | -0.181000 | 0.173000 | -0.206000 | 2.74e-02 | 2.84e-04 | 1.33e-01 | 1.50e-01 | 8.72e-02 |
| REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS | 12 | 1.28e-01 | 2.23e-01 | 0.6060 | -2.05e-01 | -0.204000 | 0.345000 | 0.039200 | 0.403000 | 2.19e-01 | 2.22e-01 | 3.84e-02 | 8.14e-01 | 1.56e-02 |
| PLATELET SENSITIZATION BY LDL | 15 | 8.42e-03 | 2.75e-02 | 0.6020 | -8.17e-03 | 0.497000 | -0.050500 | 0.335000 | -0.033200 | 9.56e-01 | 8.68e-04 | 7.35e-01 | 2.46e-02 | 8.24e-01 |
| CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | 11 | 2.00e-02 | 5.48e-02 | 0.6020 | -5.03e-01 | 0.008950 | 0.237000 | 0.090900 | 0.211000 | 3.88e-03 | 9.59e-01 | 1.74e-01 | 6.02e-01 | 2.25e-01 |
| TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX | 12 | 1.69e-01 | 2.69e-01 | 0.6010 | 6.46e-02 | 0.404000 | -0.238000 | 0.302000 | -0.216000 | 6.99e-01 | 1.54e-02 | 1.54e-01 | 6.98e-02 | 1.95e-01 |
| PYRUVATE METABOLISM | 27 | 2.92e-03 | 1.22e-02 | 0.6000 | -5.03e-02 | 0.341000 | -0.386000 | 0.191000 | -0.235000 | 6.51e-01 | 2.15e-03 | 5.19e-04 | 8.56e-02 | 3.46e-02 |
| REGULATION OF RUNX2 EXPRESSION AND ACTIVITY | 67 | 3.12e-08 | 4.77e-07 | 0.5990 | 2.80e-01 | 0.269000 | -0.363000 | -0.062400 | -0.270000 | 7.62e-05 | 1.41e-04 | 2.73e-07 | 3.78e-01 | 1.35e-04 |
| REGULATION OF TLR BY ENDOGENOUS LIGAND | 11 | 2.09e-01 | 3.14e-01 | 0.5990 | 3.09e-01 | 0.320000 | -0.350000 | -0.046300 | -0.192000 | 7.64e-02 | 6.61e-02 | 4.44e-02 | 7.90e-01 | 2.71e-01 |
| CTLA4 INHIBITORY SIGNALING | 19 | 3.48e-03 | 1.37e-02 | 0.5980 | -1.04e-01 | 0.403000 | -0.088300 | 0.414000 | -0.077200 | 4.33e-01 | 2.38e-03 | 5.05e-01 | 1.78e-03 | 5.60e-01 |
| PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING | 11 | 5.98e-02 | 1.27e-01 | 0.5980 | -3.24e-01 | -0.094400 | 0.362000 | -0.131000 | 0.308000 | 6.26e-02 | 5.88e-01 | 3.75e-02 | 4.53e-01 | 7.66e-02 |
| APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS | 80 | 6.68e-10 | 1.80e-08 | 0.5980 | 2.80e-01 | 0.253000 | -0.354000 | 0.011800 | -0.300000 | 1.52e-05 | 9.47e-05 | 4.61e-08 | 8.55e-01 | 3.59e-06 |
| COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING | 35 | 2.18e-04 | 1.34e-03 | 0.5970 | 2.47e-01 | 0.383000 | -0.364000 | 0.090700 | -0.089800 | 1.15e-02 | 8.70e-05 | 1.96e-04 | 3.53e-01 | 3.58e-01 |
| SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | 16 | 5.03e-03 | 1.83e-02 | 0.5950 | -3.22e-01 | 0.017900 | 0.112000 | 0.442000 | -0.205000 | 2.59e-02 | 9.01e-01 | 4.38e-01 | 2.22e-03 | 1.56e-01 |
| NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 20 | 3.97e-03 | 1.52e-02 | 0.5940 | -2.79e-02 | -0.020200 | 0.361000 | -0.012700 | 0.471000 | 8.29e-01 | 8.76e-01 | 5.25e-03 | 9.22e-01 | 2.65e-04 |
| METHYLATION | 11 | 2.48e-01 | 3.58e-01 | 0.5940 | 1.92e-01 | 0.362000 | -0.386000 | 0.009990 | -0.188000 | 2.71e-01 | 3.75e-02 | 2.67e-02 | 9.54e-01 | 2.80e-01 |
| BBSOME MEDIATED CARGO TARGETING TO CILIUM | 23 | 4.33e-03 | 1.62e-02 | 0.5930 | 1.81e-01 | 0.282000 | -0.170000 | 0.421000 | -0.181000 | 1.33e-01 | 1.92e-02 | 1.57e-01 | 4.70e-04 | 1.34e-01 |
| SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | 14 | 6.26e-02 | 1.32e-01 | 0.5920 | -1.36e-01 | -0.174000 | 0.443000 | 0.231000 | 0.227000 | 3.79e-01 | 2.60e-01 | 4.08e-03 | 1.34e-01 | 1.41e-01 |
| CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX | 10 | 2.86e-01 | 3.97e-01 | 0.5920 | -5.36e-02 | 0.211000 | -0.411000 | -0.079900 | -0.357000 | 7.69e-01 | 2.48e-01 | 2.44e-02 | 6.62e-01 | 5.07e-02 |
| EARLY PHASE OF HIV LIFE CYCLE | 13 | 1.18e-01 | 2.10e-01 | 0.5880 | -1.30e-01 | 0.202000 | -0.386000 | -0.148000 | -0.342000 | 4.18e-01 | 2.07e-01 | 1.59e-02 | 3.54e-01 | 3.30e-02 |
| SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL | 25 | 1.24e-03 | 5.99e-03 | 0.5860 | -9.37e-02 | -0.048300 | 0.403000 | 0.285000 | 0.299000 | 4.18e-01 | 6.76e-01 | 4.84e-04 | 1.37e-02 | 9.79e-03 |
| RECEPTOR MEDIATED MITOPHAGY | 11 | 1.42e-01 | 2.41e-01 | 0.5820 | -1.59e-01 | 0.336000 | -0.147000 | 0.322000 | -0.274000 | 3.60e-01 | 5.37e-02 | 4.00e-01 | 6.41e-02 | 1.16e-01 |
| METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES | 20 | 2.25e-03 | 9.52e-03 | 0.5810 | 4.60e-01 | 0.280000 | -0.097000 | -0.020200 | -0.194000 | 3.70e-04 | 3.04e-02 | 4.53e-01 | 8.76e-01 | 1.34e-01 |
| GLUTATHIONE SYNTHESIS AND RECYCLING | 11 | 2.60e-02 | 6.68e-02 | 0.5800 | 3.72e-01 | 0.323000 | 0.074300 | 0.209000 | -0.212000 | 3.27e-02 | 6.36e-02 | 6.70e-01 | 2.30e-01 | 2.23e-01 |
| ADENYLATE CYCLASE INHIBITORY PATHWAY | 13 | 2.90e-02 | 7.19e-02 | 0.5800 | -1.63e-01 | 0.043100 | 0.271000 | 0.338000 | 0.347000 | 3.09e-01 | 7.88e-01 | 9.03e-02 | 3.49e-02 | 3.03e-02 |
| FCERI MEDIATED NF KB ACTIVATION | 76 | 1.17e-08 | 1.99e-07 | 0.5790 | 2.86e-01 | 0.317000 | -0.289000 | 0.002560 | -0.263000 | 1.60e-05 | 1.77e-06 | 1.35e-05 | 9.69e-01 | 7.60e-05 |
| SIGNAL AMPLIFICATION | 30 | 9.82e-05 | 6.94e-04 | 0.5780 | 3.02e-01 | 0.414000 | -0.169000 | 0.151000 | 0.140000 | 4.25e-03 | 8.53e-05 | 1.09e-01 | 1.53e-01 | 1.85e-01 |
| SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS | 15 | 1.41e-02 | 4.11e-02 | 0.5780 | -2.34e-01 | 0.393000 | -0.086300 | 0.295000 | -0.172000 | 1.17e-01 | 8.35e-03 | 5.63e-01 | 4.76e-02 | 2.48e-01 |
| FRS MEDIATED FGFR4 SIGNALING | 12 | 7.35e-02 | 1.49e-01 | 0.5750 | 1.29e-01 | 0.508000 | -0.224000 | 0.030400 | -0.068100 | 4.39e-01 | 2.29e-03 | 1.79e-01 | 8.55e-01 | 6.83e-01 |
| NRAGE SIGNALS DEATH THROUGH JNK | 55 | 2.92e-07 | 3.61e-06 | 0.5730 | -1.56e-01 | -0.173000 | 0.434000 | 0.202000 | 0.213000 | 4.52e-02 | 2.63e-02 | 2.59e-08 | 9.73e-03 | 6.29e-03 |
| FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES | 15 | 4.81e-02 | 1.09e-01 | 0.5730 | 2.76e-01 | 0.431000 | -0.116000 | 0.229000 | 0.029000 | 6.47e-02 | 3.88e-03 | 4.35e-01 | 1.24e-01 | 8.46e-01 |
| SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE | 86 | 2.16e-09 | 4.64e-08 | 0.5730 | 2.05e-01 | 0.232000 | -0.365000 | -0.014200 | -0.314000 | 1.01e-03 | 1.99e-04 | 5.07e-09 | 8.20e-01 | 4.73e-07 |
| NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX | 32 | 3.25e-03 | 1.31e-02 | 0.5720 | -3.60e-02 | -0.270000 | 0.286000 | -0.139000 | 0.390000 | 7.25e-01 | 8.31e-03 | 5.16e-03 | 1.73e-01 | 1.33e-04 |
| ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | 11 | 2.04e-01 | 3.09e-01 | 0.5720 | 2.03e-01 | 0.341000 | -0.397000 | 0.041800 | -0.099400 | 2.45e-01 | 5.04e-02 | 2.25e-02 | 8.11e-01 | 5.68e-01 |
| SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | 15 | 2.40e-02 | 6.27e-02 | 0.5670 | -3.07e-01 | -0.087400 | 0.288000 | 0.365000 | 0.055900 | 3.97e-02 | 5.58e-01 | 5.36e-02 | 1.43e-02 | 7.08e-01 |
| SIGNALING BY FGFR3 FUSIONS IN CANCER | 10 | 1.32e-01 | 2.29e-01 | 0.5650 | 1.10e-01 | 0.492000 | -0.253000 | 0.035700 | -0.012200 | 5.45e-01 | 7.05e-03 | 1.66e-01 | 8.45e-01 | 9.47e-01 |
| CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE | 11 | 5.83e-02 | 1.26e-01 | 0.5650 | -3.07e-01 | 0.335000 | -0.267000 | 0.173000 | -0.108000 | 7.78e-02 | 5.46e-02 | 1.25e-01 | 3.20e-01 | 5.37e-01 |
| ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | 15 | 3.37e-02 | 8.20e-02 | 0.5640 | -4.14e-01 | -0.249000 | 0.164000 | 0.052200 | 0.233000 | 5.46e-03 | 9.49e-02 | 2.71e-01 | 7.26e-01 | 1.17e-01 |
| PROTEIN UBIQUITINATION | 69 | 2.28e-06 | 2.38e-05 | 0.5640 | 1.57e-01 | 0.311000 | -0.331000 | 0.107000 | -0.275000 | 2.44e-02 | 8.01e-06 | 1.98e-06 | 1.24e-01 | 8.09e-05 |
| NUCLEAR PORE COMPLEX NPC DISASSEMBLY | 31 | 8.15e-05 | 5.84e-04 | 0.5640 | -4.22e-01 | -0.130000 | 0.225000 | 0.268000 | 0.003920 | 4.74e-05 | 2.11e-01 | 3.03e-02 | 9.73e-03 | 9.70e-01 |
| SIGNALING BY ROBO RECEPTORS | 205 | 3.04e-29 | 2.52e-27 | 0.5620 | 3.22e-01 | 0.296000 | -0.319000 | -0.145000 | -0.043500 | 2.02e-15 | 3.02e-13 | 3.48e-15 | 3.59e-04 | 2.84e-01 |
| PROCESSING OF SMDT1 | 16 | 5.50e-02 | 1.20e-01 | 0.5600 | 8.84e-02 | 0.118000 | -0.426000 | 0.053200 | -0.327000 | 5.40e-01 | 4.15e-01 | 3.16e-03 | 7.13e-01 | 2.35e-02 |
| CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY | 84 | 9.87e-09 | 1.73e-07 | 0.5590 | 2.76e-01 | 0.283000 | -0.288000 | 0.093000 | -0.255000 | 1.28e-05 | 7.16e-06 | 5.04e-06 | 1.41e-01 | 5.48e-05 |
| E2F MEDIATED REGULATION OF DNA REPLICATION | 19 | 3.66e-02 | 8.74e-02 | 0.5590 | -9.39e-02 | 0.211000 | -0.210000 | 0.279000 | -0.370000 | 4.79e-01 | 1.11e-01 | 1.13e-01 | 3.53e-02 | 5.29e-03 |
| COMPLEMENT CASCADE | 22 | 4.38e-03 | 1.63e-02 | 0.5560 | 3.62e-01 | 0.385000 | -0.147000 | 0.006400 | 0.093000 | 3.32e-03 | 1.76e-03 | 2.33e-01 | 9.59e-01 | 4.50e-01 |
| INTERLEUKIN 12 FAMILY SIGNALING | 42 | 5.06e-04 | 2.74e-03 | 0.5560 | 1.96e-01 | 0.278000 | -0.380000 | 0.004190 | -0.221000 | 2.79e-02 | 1.80e-03 | 2.05e-05 | 9.63e-01 | 1.32e-02 |
| O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS | 34 | 1.55e-03 | 7.03e-03 | 0.5550 | -2.33e-01 | -0.326000 | 0.305000 | -0.203000 | 0.115000 | 1.89e-02 | 9.96e-04 | 2.10e-03 | 4.06e-02 | 2.44e-01 |
| REGULATION OF PTEN STABILITY AND ACTIVITY | 66 | 1.65e-06 | 1.80e-05 | 0.5550 | 2.75e-01 | 0.317000 | -0.305000 | 0.029800 | -0.193000 | 1.12e-04 | 8.23e-06 | 1.87e-05 | 6.75e-01 | 6.61e-03 |
| RRNA PROCESSING | 194 | 1.34e-26 | 1.04e-24 | 0.5530 | 3.21e-01 | 0.253000 | -0.314000 | -0.184000 | -0.079300 | 1.36e-14 | 1.24e-09 | 4.66e-14 | 9.72e-06 | 5.72e-02 |
| PI 3K CASCADE FGFR4 | 10 | 9.19e-02 | 1.76e-01 | 0.5530 | -6.21e-02 | 0.501000 | -0.180000 | 0.128000 | -0.045200 | 7.34e-01 | 6.04e-03 | 3.25e-01 | 4.82e-01 | 8.04e-01 |
| DNA REPLICATION PRE INITIATION | 79 | 9.61e-08 | 1.28e-06 | 0.5530 | 2.22e-01 | 0.254000 | -0.326000 | 0.048800 | -0.287000 | 6.45e-04 | 9.38e-05 | 5.29e-07 | 4.53e-01 | 1.03e-05 |
| CROSSLINKING OF COLLAGEN FIBRILS | 13 | 7.64e-02 | 1.53e-01 | 0.5520 | -1.59e-01 | -0.266000 | 0.433000 | -0.121000 | 0.081800 | 3.22e-01 | 9.72e-02 | 6.81e-03 | 4.51e-01 | 6.10e-01 |
| DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE | 20 | 8.78e-03 | 2.84e-02 | 0.5510 | 2.70e-01 | -0.069800 | 0.170000 | 0.037300 | 0.443000 | 3.64e-02 | 5.89e-01 | 1.88e-01 | 7.73e-01 | 6.11e-04 |
| PHASE 0 RAPID DEPOLARISATION | 28 | 2.06e-03 | 8.80e-03 | 0.5490 | -3.92e-01 | -0.215000 | 0.218000 | -0.146000 | 0.179000 | 3.29e-04 | 4.88e-02 | 4.63e-02 | 1.80e-01 | 1.00e-01 |
| NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS | 10 | 2.72e-01 | 3.82e-01 | 0.5480 | 2.14e-01 | -0.222000 | 0.361000 | 0.021900 | 0.274000 | 2.40e-01 | 2.25e-01 | 4.82e-02 | 9.05e-01 | 1.34e-01 |
| ACETYLCHOLINE REGULATES INSULIN SECRETION | 10 | 1.40e-01 | 2.37e-01 | 0.5470 | -6.81e-02 | -0.014200 | 0.246000 | 0.108000 | 0.471000 | 7.09e-01 | 9.38e-01 | 1.78e-01 | 5.55e-01 | 9.92e-03 |
| TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT | 18 | 7.74e-02 | 1.54e-01 | 0.5460 | 3.23e-01 | 0.314000 | -0.275000 | 0.015900 | -0.138000 | 1.75e-02 | 2.13e-02 | 4.32e-02 | 9.07e-01 | 3.10e-01 |
| GLYCOGEN STORAGE DISEASES | 12 | 1.07e-01 | 1.96e-01 | 0.5460 | 1.56e-01 | 0.446000 | -0.188000 | 0.190000 | 0.052500 | 3.49e-01 | 7.41e-03 | 2.59e-01 | 2.54e-01 | 7.53e-01 |
| REGULATION OF RAS BY GAPS | 66 | 2.09e-06 | 2.22e-05 | 0.5410 | 2.88e-01 | 0.274000 | -0.310000 | 0.027200 | -0.193000 | 5.19e-05 | 1.16e-04 | 1.31e-05 | 7.03e-01 | 6.64e-03 |
| TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | 13 | 2.73e-01 | 3.82e-01 | 0.5410 | 2.57e-02 | -0.234000 | 0.325000 | -0.000825 | 0.362000 | 8.72e-01 | 1.44e-01 | 4.27e-02 | 9.96e-01 | 2.37e-02 |
| ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 | 10 | 2.25e-01 | 3.34e-01 | 0.5400 | 1.82e-01 | 0.396000 | -0.233000 | 0.213000 | 0.041900 | 3.18e-01 | 3.01e-02 | 2.01e-01 | 2.45e-01 | 8.18e-01 |
| INTERLEUKIN 37 SIGNALING | 17 | 6.69e-03 | 2.26e-02 | 0.5400 | 9.02e-02 | 0.161000 | 0.384000 | 0.217000 | 0.250000 | 5.20e-01 | 2.51e-01 | 6.12e-03 | 1.21e-01 | 7.39e-02 |
| SHC MEDIATED CASCADE FGFR3 | 12 | 5.61e-02 | 1.22e-01 | 0.5400 | 9.53e-02 | 0.488000 | -0.183000 | -0.074400 | -0.072400 | 5.68e-01 | 3.44e-03 | 2.73e-01 | 6.55e-01 | 6.64e-01 |
| RORA ACTIVATES GENE EXPRESSION | 18 | 7.11e-02 | 1.46e-01 | 0.5380 | 7.91e-02 | -0.123000 | 0.394000 | 0.049000 | 0.331000 | 5.61e-01 | 3.67e-01 | 3.77e-03 | 7.19e-01 | 1.49e-02 |
| GLYCOGEN METABOLISM | 25 | 6.13e-03 | 2.12e-02 | 0.5370 | 1.99e-01 | 0.382000 | -0.204000 | 0.247000 | 0.026700 | 8.59e-02 | 9.53e-04 | 7.80e-02 | 3.28e-02 | 8.18e-01 |
| MITOPHAGY | 29 | 7.22e-03 | 2.41e-02 | 0.5360 | 1.37e-01 | 0.424000 | -0.246000 | 0.103000 | -0.135000 | 2.02e-01 | 7.81e-05 | 2.21e-02 | 3.36e-01 | 2.09e-01 |
| PKA ACTIVATION IN GLUCAGON SIGNALLING | 16 | 2.25e-03 | 9.52e-03 | 0.5360 | -3.10e-01 | 0.133000 | 0.185000 | 0.134000 | 0.348000 | 3.16e-02 | 3.58e-01 | 2.00e-01 | 3.53e-01 | 1.60e-02 |
| INSULIN RECEPTOR RECYCLING | 20 | 9.56e-02 | 1.80e-01 | 0.5330 | 4.91e-02 | 0.356000 | -0.305000 | 0.121000 | -0.219000 | 7.04e-01 | 5.80e-03 | 1.84e-02 | 3.50e-01 | 9.05e-02 |
| SUPPRESSION OF PHAGOSOMAL MATURATION | 12 | 2.90e-01 | 4.01e-01 | 0.5310 | -3.17e-02 | 0.345000 | -0.244000 | 0.239000 | -0.214000 | 8.49e-01 | 3.87e-02 | 1.44e-01 | 1.51e-01 | 1.99e-01 |
| IRAK4 DEFICIENCY TLR2 4 | 12 | 2.30e-01 | 3.40e-01 | 0.5300 | 2.15e-01 | 0.298000 | -0.370000 | -0.015300 | -0.091000 | 1.96e-01 | 7.36e-02 | 2.63e-02 | 9.27e-01 | 5.85e-01 |
| GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION | 11 | 1.86e-01 | 2.88e-01 | 0.5290 | -2.57e-01 | 0.236000 | -0.114000 | 0.287000 | -0.249000 | 1.39e-01 | 1.75e-01 | 5.13e-01 | 9.92e-02 | 1.53e-01 |
| PROTEIN LOCALIZATION | 156 | 2.83e-14 | 1.06e-12 | 0.5290 | 2.31e-01 | 0.307000 | -0.253000 | 0.120000 | -0.232000 | 6.83e-07 | 3.89e-11 | 5.29e-08 | 9.98e-03 | 5.60e-07 |
| PROCESSING AND ACTIVATION OF SUMO | 10 | 4.55e-01 | 5.47e-01 | 0.5280 | 5.64e-02 | 0.281000 | -0.354000 | 0.140000 | -0.227000 | 7.58e-01 | 1.24e-01 | 5.27e-02 | 4.43e-01 | 2.13e-01 |
| REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 15 | 6.06e-02 | 1.29e-01 | 0.5270 | -9.78e-02 | 0.311000 | -0.245000 | 0.325000 | -0.077600 | 5.12e-01 | 3.71e-02 | 1.00e-01 | 2.94e-02 | 6.03e-01 |
| HDMS DEMETHYLATE HISTONES | 26 | 8.70e-03 | 2.82e-02 | 0.5270 | -2.84e-01 | -0.160000 | 0.344000 | -0.016800 | 0.230000 | 1.22e-02 | 1.58e-01 | 2.40e-03 | 8.82e-01 | 4.27e-02 |
| FRS MEDIATED FGFR3 SIGNALING | 14 | 4.39e-02 | 1.02e-01 | 0.5270 | 1.11e-01 | 0.492000 | -0.139000 | 0.044600 | -0.046100 | 4.72e-01 | 1.45e-03 | 3.68e-01 | 7.73e-01 | 7.65e-01 |
| CAMK IV MEDIATED PHOSPHORYLATION OF CREB | 10 | 1.37e-01 | 2.34e-01 | 0.5270 | -2.54e-01 | -0.133000 | 0.169000 | 0.398000 | -0.087800 | 1.64e-01 | 4.66e-01 | 3.54e-01 | 2.92e-02 | 6.31e-01 |
| DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | 23 | 1.57e-02 | 4.53e-02 | 0.5260 | -3.65e-01 | -0.251000 | 0.186000 | -0.032400 | 0.211000 | 2.43e-03 | 3.71e-02 | 1.22e-01 | 7.88e-01 | 7.94e-02 |
| CHOLESTEROL BIOSYNTHESIS | 24 | 2.01e-02 | 5.48e-02 | 0.5260 | -2.16e-02 | 0.101000 | -0.372000 | 0.041900 | -0.354000 | 8.55e-01 | 3.92e-01 | 1.60e-03 | 7.23e-01 | 2.65e-03 |
| REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | 29 | 1.04e-03 | 5.18e-03 | 0.5260 | -4.10e-01 | -0.145000 | 0.217000 | 0.196000 | 0.042800 | 1.35e-04 | 1.75e-01 | 4.30e-02 | 6.79e-02 | 6.90e-01 |
| ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 | 23 | 2.95e-03 | 1.22e-02 | 0.5250 | 3.04e-01 | 0.356000 | -0.150000 | 0.035000 | 0.180000 | 1.15e-02 | 3.08e-03 | 2.13e-01 | 7.71e-01 | 1.35e-01 |
| A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 26 | 4.94e-03 | 1.81e-02 | 0.5250 | 1.33e-01 | -0.115000 | 0.209000 | 0.031900 | 0.448000 | 2.41e-01 | 3.12e-01 | 6.53e-02 | 7.78e-01 | 7.76e-05 |
| METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION | 15 | 6.63e-02 | 1.38e-01 | 0.5240 | 1.82e-01 | 0.455000 | -0.174000 | 0.012400 | -0.064700 | 2.22e-01 | 2.30e-03 | 2.43e-01 | 9.34e-01 | 6.64e-01 |
| AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | 24 | 5.16e-03 | 1.86e-02 | 0.5230 | 1.06e-01 | -0.071100 | 0.225000 | 0.276000 | 0.362000 | 3.70e-01 | 5.47e-01 | 5.66e-02 | 1.92e-02 | 2.15e-03 |
| ENOS ACTIVATION | 11 | 1.63e-01 | 2.64e-01 | 0.5230 | 5.51e-02 | 0.442000 | -0.271000 | -0.004150 | -0.047600 | 7.52e-01 | 1.12e-02 | 1.19e-01 | 9.81e-01 | 7.84e-01 |
| HDR THROUGH MMEJ ALT NHEJ | 10 | 1.87e-01 | 2.89e-01 | 0.5210 | -4.50e-01 | -0.127000 | 0.014900 | 0.144000 | -0.178000 | 1.37e-02 | 4.87e-01 | 9.35e-01 | 4.30e-01 | 3.30e-01 |
| RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA | 24 | 3.84e-03 | 1.48e-02 | 0.5200 | -4.19e-01 | -0.157000 | -0.122000 | -0.046700 | -0.230000 | 3.81e-04 | 1.84e-01 | 3.01e-01 | 6.92e-01 | 5.10e-02 |
| CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY | 13 | 1.18e-02 | 3.56e-02 | 0.5190 | 2.98e-01 | -0.093500 | 0.385000 | -0.142000 | 0.053500 | 6.30e-02 | 5.59e-01 | 1.62e-02 | 3.75e-01 | 7.38e-01 |
| GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION | 24 | 3.34e-02 | 8.16e-02 | 0.5190 | 1.53e-01 | 0.377000 | -0.231000 | 0.205000 | -0.089800 | 1.95e-01 | 1.39e-03 | 4.99e-02 | 8.26e-02 | 4.46e-01 |
| INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | 13 | 8.44e-02 | 1.65e-01 | 0.5180 | 2.49e-02 | 0.150000 | -0.000806 | 0.434000 | -0.240000 | 8.77e-01 | 3.49e-01 | 9.96e-01 | 6.74e-03 | 1.35e-01 |
| ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | 30 | 2.65e-02 | 6.76e-02 | 0.5180 | 8.44e-02 | 0.304000 | -0.292000 | 0.164000 | -0.239000 | 4.24e-01 | 3.99e-03 | 5.60e-03 | 1.21e-01 | 2.34e-02 |
| INITIAL TRIGGERING OF COMPLEMENT | 10 | 1.25e-01 | 2.19e-01 | 0.5160 | 3.35e-01 | 0.331000 | 0.086400 | 0.000114 | 0.192000 | 6.68e-02 | 6.98e-02 | 6.36e-01 | 1.00e+00 | 2.92e-01 |
| GLYCOSPHINGOLIPID METABOLISM | 38 | 1.10e-04 | 7.73e-04 | 0.5150 | 2.33e-01 | 0.214000 | -0.039100 | 0.363000 | -0.179000 | 1.30e-02 | 2.25e-02 | 6.77e-01 | 1.08e-04 | 5.64e-02 |
| PEROXISOMAL LIPID METABOLISM | 26 | 9.17e-03 | 2.94e-02 | 0.5150 | 2.56e-01 | 0.252000 | -0.096400 | 0.316000 | -0.163000 | 2.36e-02 | 2.62e-02 | 3.95e-01 | 5.34e-03 | 1.50e-01 |
| IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | 20 | 5.45e-02 | 1.20e-01 | 0.5130 | 3.66e-01 | 0.288000 | -0.202000 | 0.058100 | -0.043900 | 4.64e-03 | 2.56e-02 | 1.17e-01 | 6.53e-01 | 7.34e-01 |
| RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS | 80 | 7.98e-08 | 1.10e-06 | 0.5130 | 2.82e-01 | 0.250000 | -0.290000 | -0.114000 | -0.155000 | 1.28e-05 | 1.11e-04 | 7.57e-06 | 7.89e-02 | 1.66e-02 |
| E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS | 50 | 9.00e-04 | 4.54e-03 | 0.5130 | 1.60e-01 | 0.273000 | -0.314000 | 0.072100 | -0.244000 | 5.00e-02 | 8.53e-04 | 1.26e-04 | 3.78e-01 | 2.88e-03 |
| TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 26 | 5.87e-02 | 1.26e-01 | 0.5130 | 8.73e-02 | 0.313000 | -0.275000 | 0.109000 | -0.264000 | 4.41e-01 | 5.81e-03 | 1.52e-02 | 3.36e-01 | 1.98e-02 |
| PI 3K CASCADE FGFR3 | 12 | 5.05e-02 | 1.13e-01 | 0.5110 | -5.12e-02 | 0.483000 | -0.087900 | 0.129000 | -0.023400 | 7.59e-01 | 3.77e-03 | 5.98e-01 | 4.41e-01 | 8.88e-01 |
| SCAVENGING BY CLASS A RECEPTORS | 13 | 5.17e-02 | 1.15e-01 | 0.5090 | 1.35e-01 | 0.286000 | -0.268000 | -0.289000 | 0.064800 | 3.99e-01 | 7.40e-02 | 9.45e-02 | 7.13e-02 | 6.86e-01 |
| EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS | 31 | 7.38e-04 | 3.93e-03 | 0.5090 | -4.08e-01 | -0.142000 | 0.179000 | 0.199000 | -0.029600 | 8.43e-05 | 1.72e-01 | 8.51e-02 | 5.47e-02 | 7.76e-01 |
| ABC TRANSPORTER DISORDERS | 68 | 6.13e-06 | 6.01e-05 | 0.5090 | 2.72e-01 | 0.284000 | -0.294000 | 0.047800 | -0.125000 | 1.08e-04 | 5.07e-05 | 2.73e-05 | 4.96e-01 | 7.46e-02 |
| DEGRADATION OF CYSTEINE AND HOMOCYSTEINE | 12 | 2.14e-01 | 3.21e-01 | 0.5090 | 2.43e-01 | 0.349000 | -0.123000 | 0.094000 | -0.232000 | 1.44e-01 | 3.63e-02 | 4.62e-01 | 5.73e-01 | 1.65e-01 |
| CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION | 11 | 1.40e-01 | 2.37e-01 | 0.5080 | -1.43e-01 | 0.416000 | -0.157000 | 0.178000 | -0.090900 | 4.11e-01 | 1.68e-02 | 3.67e-01 | 3.08e-01 | 6.02e-01 |
| BETA CATENIN PHOSPHORYLATION CASCADE | 16 | 2.83e-02 | 7.07e-02 | 0.5080 | -2.59e-01 | 0.324000 | -0.067000 | 0.255000 | -0.129000 | 7.27e-02 | 2.50e-02 | 6.43e-01 | 7.79e-02 | 3.72e-01 |
| CELLULAR RESPONSE TO CHEMICAL STRESS | 148 | 9.27e-15 | 3.58e-13 | 0.5080 | 2.88e-01 | 0.266000 | -0.261000 | -0.099900 | -0.160000 | 1.45e-09 | 2.35e-08 | 4.19e-08 | 3.62e-02 | 7.65e-04 |
| CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND | 10 | 1.48e-01 | 2.47e-01 | 0.5070 | -4.46e-01 | -0.050500 | 0.121000 | 0.147000 | 0.142000 | 1.47e-02 | 7.82e-01 | 5.09e-01 | 4.22e-01 | 4.37e-01 |
| ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING | 10 | 2.16e-01 | 3.22e-01 | 0.5070 | -3.08e-01 | -0.286000 | 0.135000 | 0.140000 | 0.206000 | 9.15e-02 | 1.17e-01 | 4.60e-01 | 4.44e-01 | 2.59e-01 |
| DSCAM INTERACTIONS | 10 | 3.05e-01 | 4.15e-01 | 0.5060 | -4.22e-01 | -0.213000 | 0.177000 | -0.034200 | 0.003290 | 2.09e-02 | 2.43e-01 | 3.32e-01 | 8.51e-01 | 9.86e-01 |
| PHASE II CONJUGATION OF COMPOUNDS | 60 | 4.17e-05 | 3.29e-04 | 0.5030 | 2.58e-01 | 0.314000 | -0.194000 | 0.109000 | -0.197000 | 5.53e-04 | 2.66e-05 | 9.22e-03 | 1.44e-01 | 8.48e-03 |
| COHESIN LOADING ONTO CHROMATIN | 10 | 3.78e-01 | 4.79e-01 | 0.5020 | 4.61e-02 | 0.209000 | -0.156000 | 0.350000 | -0.244000 | 8.01e-01 | 2.52e-01 | 3.93e-01 | 5.54e-02 | 1.81e-01 |
| TRP CHANNELS | 18 | 1.15e-01 | 2.06e-01 | 0.5010 | -1.43e-01 | -0.382000 | 0.261000 | 0.002600 | 0.127000 | 2.93e-01 | 4.99e-03 | 5.53e-02 | 9.85e-01 | 3.52e-01 |
| RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION | 49 | 4.37e-05 | 3.39e-04 | 0.4980 | 3.66e-02 | -0.178000 | 0.218000 | -0.355000 | 0.204000 | 6.58e-01 | 3.15e-02 | 8.35e-03 | 1.75e-05 | 1.34e-02 |
| IRON UPTAKE AND TRANSPORT | 52 | 7.94e-04 | 4.09e-03 | 0.4980 | 1.03e-01 | 0.342000 | -0.259000 | 0.137000 | -0.185000 | 1.97e-01 | 1.98e-05 | 1.26e-03 | 8.75e-02 | 2.09e-02 |
| SYNTHESIS OF PE | 12 | 1.50e-01 | 2.48e-01 | 0.4980 | 1.59e-01 | -0.154000 | 0.293000 | 0.292000 | 0.167000 | 3.41e-01 | 3.56e-01 | 7.91e-02 | 8.02e-02 | 3.18e-01 |
| SPHINGOLIPID METABOLISM | 79 | 1.38e-08 | 2.25e-07 | 0.4970 | 1.65e-01 | 0.263000 | -0.036600 | 0.361000 | -0.139000 | 1.14e-02 | 5.46e-05 | 5.75e-01 | 2.80e-08 | 3.34e-02 |
| DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX | 82 | 1.11e-06 | 1.27e-05 | 0.4970 | 2.07e-01 | 0.328000 | -0.254000 | -0.006120 | -0.180000 | 1.21e-03 | 2.86e-07 | 7.09e-05 | 9.24e-01 | 4.88e-03 |
| INTERLEUKIN 6 FAMILY SIGNALING | 18 | 2.29e-02 | 6.06e-02 | 0.4970 | 3.20e-01 | -0.017100 | 0.307000 | 0.151000 | 0.164000 | 1.87e-02 | 9.00e-01 | 2.40e-02 | 2.66e-01 | 2.29e-01 |
| ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | 15 | 8.84e-02 | 1.71e-01 | 0.4960 | 3.51e-01 | 0.170000 | 0.078800 | 0.262000 | 0.136000 | 1.85e-02 | 2.55e-01 | 5.97e-01 | 7.87e-02 | 3.63e-01 |
| TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX | 17 | 4.97e-02 | 1.12e-01 | 0.4950 | 1.97e-01 | 0.173000 | -0.027100 | 0.383000 | -0.171000 | 1.61e-01 | 2.18e-01 | 8.47e-01 | 6.31e-03 | 2.21e-01 |
| TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES | 10 | 1.81e-01 | 2.84e-01 | 0.4950 | -2.83e-01 | -0.191000 | 0.126000 | -0.287000 | -0.174000 | 1.21e-01 | 2.95e-01 | 4.91e-01 | 1.17e-01 | 3.40e-01 |
| SPHINGOLIPID DE NOVO BIOSYNTHESIS | 41 | 3.58e-04 | 2.03e-03 | 0.4940 | 1.01e-01 | 0.307000 | -0.034100 | 0.358000 | -0.100000 | 2.64e-01 | 6.83e-04 | 7.06e-01 | 7.22e-05 | 2.66e-01 |
| NEPHRIN FAMILY INTERACTIONS | 22 | 1.98e-02 | 5.45e-02 | 0.4930 | -7.14e-03 | 0.032600 | 0.313000 | 0.265000 | 0.272000 | 9.54e-01 | 7.92e-01 | 1.11e-02 | 3.15e-02 | 2.71e-02 |
| ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS | 18 | 1.57e-02 | 4.53e-02 | 0.4930 | 3.73e-01 | -0.115000 | 0.271000 | 0.034600 | 0.124000 | 6.11e-03 | 3.99e-01 | 4.64e-02 | 7.99e-01 | 3.61e-01 |
| NUCLEOBASE BIOSYNTHESIS | 15 | 7.15e-02 | 1.46e-01 | 0.4930 | -1.46e-01 | 0.304000 | -0.050700 | 0.352000 | -0.049700 | 3.28e-01 | 4.13e-02 | 7.34e-01 | 1.84e-02 | 7.39e-01 |
| NUCLEAR IMPORT OF REV PROTEIN | 32 | 7.41e-04 | 3.93e-03 | 0.4920 | -3.73e-01 | -0.096800 | 0.190000 | 0.238000 | -0.028900 | 2.56e-04 | 3.43e-01 | 6.36e-02 | 1.99e-02 | 7.77e-01 |
| ASYMMETRIC LOCALIZATION OF PCP PROTEINS | 62 | 2.03e-05 | 1.77e-04 | 0.4920 | 3.18e-01 | 0.254000 | -0.242000 | -0.026700 | -0.132000 | 1.50e-05 | 5.55e-04 | 9.97e-04 | 7.16e-01 | 7.27e-02 |
| PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES | 13 | 1.86e-01 | 2.88e-01 | 0.4910 | -3.47e-02 | 0.351000 | -0.071300 | 0.298000 | -0.153000 | 8.29e-01 | 2.87e-02 | 6.56e-01 | 6.28e-02 | 3.38e-01 |
| GAP JUNCTION DEGRADATION | 11 | 2.75e-01 | 3.84e-01 | 0.4900 | 1.23e-01 | 0.384000 | -0.204000 | 0.189000 | 0.020400 | 4.79e-01 | 2.74e-02 | 2.41e-01 | 2.79e-01 | 9.07e-01 |
| NR1H2 AND NR1H3 MEDIATED SIGNALING | 38 | 3.15e-03 | 1.28e-02 | 0.4900 | 3.63e-02 | -0.144000 | 0.245000 | -0.059600 | 0.393000 | 6.99e-01 | 1.24e-01 | 8.99e-03 | 5.25e-01 | 2.77e-05 |
| TNFR1 INDUCED PROAPOPTOTIC SIGNALING | 12 | 1.33e-01 | 2.30e-01 | 0.4900 | 2.67e-01 | 0.090300 | 0.074700 | 0.176000 | 0.352000 | 1.10e-01 | 5.88e-01 | 6.54e-01 | 2.90e-01 | 3.47e-02 |
| NEUROTOXICITY OF CLOSTRIDIUM TOXINS | 10 | 1.13e-01 | 2.04e-01 | 0.4900 | -4.53e-01 | -0.072600 | 0.004220 | 0.070500 | 0.157000 | 1.32e-02 | 6.91e-01 | 9.82e-01 | 6.99e-01 | 3.89e-01 |
| PROLONGED ERK ACTIVATION EVENTS | 13 | 1.60e-01 | 2.61e-01 | 0.4890 | -1.85e-01 | 0.178000 | -0.038500 | 0.344000 | -0.231000 | 2.48e-01 | 2.68e-01 | 8.10e-01 | 3.17e-02 | 1.49e-01 |
| CLEC7A DECTIN 1 SIGNALING | 94 | 1.02e-07 | 1.33e-06 | 0.4890 | 2.33e-01 | 0.285000 | -0.230000 | -0.002360 | -0.225000 | 9.82e-05 | 1.79e-06 | 1.17e-04 | 9.69e-01 | 1.66e-04 |
| FATTY ACID METABOLISM | 144 | 3.54e-12 | 1.17e-10 | 0.4890 | 2.60e-01 | 0.307000 | -0.184000 | 0.171000 | -0.116000 | 6.98e-08 | 1.96e-10 | 1.45e-04 | 4.03e-04 | 1.63e-02 |
| TRANSLESION SYNTHESIS BY POLK | 17 | 1.44e-01 | 2.42e-01 | 0.4890 | 2.84e-02 | 0.150000 | -0.377000 | -0.151000 | -0.224000 | 8.39e-01 | 2.86e-01 | 7.08e-03 | 2.80e-01 | 1.10e-01 |
| FRS MEDIATED FGFR2 SIGNALING | 17 | 8.30e-02 | 1.63e-01 | 0.4880 | 6.80e-02 | 0.346000 | -0.193000 | -0.079500 | -0.266000 | 6.27e-01 | 1.36e-02 | 1.69e-01 | 5.70e-01 | 5.73e-02 |
| PRE NOTCH PROCESSING IN GOLGI | 17 | 1.53e-02 | 4.44e-02 | 0.4880 | 1.24e-01 | 0.175000 | 0.342000 | 0.191000 | 0.197000 | 3.77e-01 | 2.13e-01 | 1.46e-02 | 1.73e-01 | 1.59e-01 |
| CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 | 11 | 2.56e-01 | 3.65e-01 | 0.4870 | 1.95e-01 | 0.348000 | -0.226000 | -0.154000 | -0.055500 | 2.63e-01 | 4.55e-02 | 1.94e-01 | 3.75e-01 | 7.50e-01 |
| REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM | 11 | 3.47e-02 | 8.40e-02 | 0.4870 | -3.76e-01 | 0.181000 | 0.188000 | 0.105000 | -0.130000 | 3.10e-02 | 3.00e-01 | 2.80e-01 | 5.46e-01 | 4.55e-01 |
| CYTOCHROME C MEDIATED APOPTOTIC RESPONSE | 12 | 2.61e-01 | 3.71e-01 | 0.4870 | 1.88e-01 | 0.127000 | -0.345000 | 0.107000 | -0.234000 | 2.59e-01 | 4.46e-01 | 3.86e-02 | 5.20e-01 | 1.60e-01 |
| GP1B IX V ACTIVATION SIGNALLING | 10 | 4.85e-01 | 5.76e-01 | 0.4860 | -1.32e-01 | -0.232000 | 0.206000 | -0.132000 | 0.324000 | 4.68e-01 | 2.05e-01 | 2.58e-01 | 4.69e-01 | 7.57e-02 |
| NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | 17 | 1.29e-02 | 3.82e-02 | 0.4860 | -3.71e-01 | -0.155000 | 0.046900 | 0.069800 | 0.259000 | 8.09e-03 | 2.68e-01 | 7.38e-01 | 6.18e-01 | 6.45e-02 |
| MITOCHONDRIAL CALCIUM ION TRANSPORT | 23 | 1.15e-01 | 2.06e-01 | 0.4850 | -2.36e-03 | 0.257000 | -0.327000 | 0.018600 | -0.250000 | 9.84e-01 | 3.30e-02 | 6.69e-03 | 8.77e-01 | 3.80e-02 |
| BUDDING AND MATURATION OF HIV VIRION | 27 | 6.09e-02 | 1.29e-01 | 0.4830 | 1.15e-01 | 0.306000 | -0.267000 | 0.173000 | -0.159000 | 3.02e-01 | 5.94e-03 | 1.62e-02 | 1.19e-01 | 1.52e-01 |
| PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | 15 | 9.87e-02 | 1.85e-01 | 0.4830 | 2.86e-01 | 0.154000 | -0.096500 | 0.339000 | -0.064000 | 5.53e-02 | 3.03e-01 | 5.18e-01 | 2.31e-02 | 6.68e-01 |
| IRE1ALPHA ACTIVATES CHAPERONES | 49 | 1.83e-05 | 1.62e-04 | 0.4810 | 1.20e-01 | 0.105000 | 0.231000 | 0.291000 | 0.260000 | 1.46e-01 | 2.05e-01 | 5.15e-03 | 4.20e-04 | 1.65e-03 |
| INFECTION WITH MYCOBACTERIUM TUBERCULOSIS | 24 | 3.53e-02 | 8.51e-02 | 0.4800 | 9.64e-02 | 0.392000 | -0.146000 | 0.202000 | -0.072100 | 4.14e-01 | 8.76e-04 | 2.16e-01 | 8.68e-02 | 5.41e-01 |
| NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 23 | 5.64e-03 | 2.00e-02 | 0.4800 | -1.28e-01 | -0.069800 | 0.159000 | 0.032900 | 0.428000 | 2.87e-01 | 5.62e-01 | 1.88e-01 | 7.85e-01 | 3.84e-04 |
| TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS | 11 | 7.51e-02 | 1.51e-01 | 0.4800 | -2.15e-01 | 0.092700 | 0.093700 | 0.253000 | 0.321000 | 2.17e-01 | 5.94e-01 | 5.90e-01 | 1.46e-01 | 6.55e-02 |
| G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | 23 | 2.37e-02 | 6.21e-02 | 0.4800 | 2.58e-01 | 0.344000 | -0.202000 | -0.059900 | 0.027000 | 3.21e-02 | 4.28e-03 | 9.38e-02 | 6.19e-01 | 8.23e-01 |
| POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION | 26 | 3.88e-03 | 1.49e-02 | 0.4800 | -2.62e-01 | -0.021500 | 0.130000 | 0.374000 | -0.061600 | 2.08e-02 | 8.50e-01 | 2.50e-01 | 9.57e-04 | 5.87e-01 |
| FORMATION OF APOPTOSOME | 10 | 5.08e-01 | 5.96e-01 | 0.4790 | 2.29e-01 | 0.217000 | -0.233000 | 0.155000 | -0.228000 | 2.09e-01 | 2.36e-01 | 2.02e-01 | 3.97e-01 | 2.13e-01 |
| DNA REPLICATION | 121 | 3.56e-09 | 7.12e-08 | 0.4790 | 1.64e-01 | 0.192000 | -0.302000 | 0.037600 | -0.270000 | 1.81e-03 | 2.63e-04 | 9.80e-09 | 4.76e-01 | 2.99e-07 |
| REPRESSION OF WNT TARGET GENES | 14 | 2.37e-02 | 6.21e-02 | 0.4790 | 1.52e-01 | 0.155000 | 0.302000 | -0.147000 | 0.263000 | 3.24e-01 | 3.16e-01 | 5.04e-02 | 3.41e-01 | 8.86e-02 |
| SULFUR AMINO ACID METABOLISM | 22 | 5.71e-02 | 1.23e-01 | 0.4790 | 2.65e-01 | 0.288000 | -0.109000 | 0.176000 | -0.181000 | 3.15e-02 | 1.93e-02 | 3.76e-01 | 1.52e-01 | 1.42e-01 |
| PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 | 10 | 1.33e-01 | 2.29e-01 | 0.4780 | -1.33e-01 | 0.154000 | -0.075400 | -0.191000 | -0.381000 | 4.67e-01 | 4.00e-01 | 6.80e-01 | 2.97e-01 | 3.69e-02 |
| FERTILIZATION | 12 | 1.94e-01 | 2.97e-01 | 0.4780 | -1.47e-01 | -0.158000 | -0.065700 | -0.421000 | 0.017800 | 3.79e-01 | 3.43e-01 | 6.94e-01 | 1.16e-02 | 9.15e-01 |
| VOLTAGE GATED POTASSIUM CHANNELS | 38 | 1.36e-03 | 6.41e-03 | 0.4770 | -3.46e-01 | -0.158000 | 0.263000 | 0.016100 | 0.114000 | 2.25e-04 | 9.11e-02 | 5.02e-03 | 8.64e-01 | 2.23e-01 |
| PKMTS METHYLATE HISTONE LYSINES | 47 | 1.38e-03 | 6.47e-03 | 0.4760 | -3.87e-02 | -0.321000 | 0.280000 | -0.164000 | 0.132000 | 6.46e-01 | 1.42e-04 | 9.15e-04 | 5.23e-02 | 1.17e-01 |
| FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES | 15 | 1.55e-01 | 2.55e-01 | 0.4760 | 2.50e-01 | -0.015900 | 0.243000 | -0.079800 | 0.314000 | 9.33e-02 | 9.15e-01 | 1.04e-01 | 5.92e-01 | 3.55e-02 |
| RRNA PROCESSING IN THE MITOCHONDRION | 10 | 3.72e-01 | 4.75e-01 | 0.4760 | -6.03e-02 | 0.044900 | -0.344000 | 0.080700 | -0.310000 | 7.41e-01 | 8.06e-01 | 5.99e-02 | 6.59e-01 | 8.95e-02 |
| DCC MEDIATED ATTRACTIVE SIGNALING | 14 | 4.88e-02 | 1.10e-01 | 0.4750 | -2.62e-01 | 0.110000 | 0.198000 | 0.226000 | 0.234000 | 8.92e-02 | 4.75e-01 | 1.99e-01 | 1.44e-01 | 1.29e-01 |
| BIOTIN TRANSPORT AND METABOLISM | 11 | 2.48e-01 | 3.58e-01 | 0.4740 | 1.18e-01 | 0.101000 | 0.184000 | 0.270000 | 0.305000 | 4.97e-01 | 5.60e-01 | 2.91e-01 | 1.21e-01 | 7.96e-02 |
| C TYPE LECTIN RECEPTORS CLRS | 110 | 4.11e-08 | 6.11e-07 | 0.4740 | 2.09e-01 | 0.291000 | -0.231000 | 0.017500 | -0.205000 | 1.56e-04 | 1.30e-07 | 2.96e-05 | 7.51e-01 | 2.01e-04 |
| PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS | 19 | 2.17e-02 | 5.82e-02 | 0.4730 | 2.41e-01 | 0.299000 | -0.226000 | 0.006890 | 0.160000 | 6.91e-02 | 2.41e-02 | 8.85e-02 | 9.59e-01 | 2.27e-01 |
| INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | 19 | 7.91e-02 | 1.57e-01 | 0.4730 | 1.26e-01 | 0.077800 | -0.334000 | 0.061200 | -0.294000 | 3.41e-01 | 5.57e-01 | 1.18e-02 | 6.44e-01 | 2.64e-02 |
| LDL CLEARANCE | 16 | 8.93e-02 | 1.72e-01 | 0.4720 | -3.61e-02 | 0.311000 | -0.120000 | 0.331000 | 0.008410 | 8.02e-01 | 3.14e-02 | 4.05e-01 | 2.17e-02 | 9.54e-01 |
| THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 27 | 3.37e-03 | 1.35e-02 | 0.4710 | 2.36e-01 | 0.333000 | -0.122000 | 0.094300 | 0.179000 | 3.39e-02 | 2.79e-03 | 2.72e-01 | 3.97e-01 | 1.07e-01 |
| APC CDC20 MEDIATED DEGRADATION OF NEK2A | 24 | 5.53e-02 | 1.20e-01 | 0.4710 | 1.67e-01 | 0.131000 | -0.339000 | 0.001770 | -0.250000 | 1.57e-01 | 2.66e-01 | 4.08e-03 | 9.88e-01 | 3.42e-02 |
| INTERLEUKIN 7 SIGNALING | 19 | 6.12e-02 | 1.29e-01 | 0.4710 | -2.69e-01 | -0.163000 | 0.160000 | -0.105000 | 0.293000 | 4.24e-02 | 2.18e-01 | 2.26e-01 | 4.28e-01 | 2.68e-02 |
| CYTOPROTECTION BY HMOX1 | 118 | 8.14e-10 | 1.93e-08 | 0.4700 | 2.55e-01 | 0.234000 | -0.240000 | -0.093800 | -0.186000 | 1.76e-06 | 1.13e-05 | 7.01e-06 | 7.87e-02 | 4.98e-04 |
| S PHASE | 153 | 1.24e-10 | 3.77e-09 | 0.4700 | 1.50e-01 | 0.222000 | -0.271000 | 0.088200 | -0.259000 | 1.43e-03 | 2.09e-06 | 7.02e-09 | 6.02e-02 | 3.23e-08 |
| ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | 23 | 8.78e-02 | 1.70e-01 | 0.4680 | 2.72e-01 | 0.257000 | -0.214000 | 0.154000 | -0.094800 | 2.39e-02 | 3.29e-02 | 7.55e-02 | 2.00e-01 | 4.31e-01 |
| PURINE CATABOLISM | 16 | 2.47e-01 | 3.58e-01 | 0.4670 | 2.63e-01 | 0.249000 | -0.277000 | 0.025600 | -0.096600 | 6.86e-02 | 8.41e-02 | 5.52e-02 | 8.59e-01 | 5.04e-01 |
| METABOLISM OF COFACTORS | 18 | 1.20e-01 | 2.13e-01 | 0.4660 | 1.28e-01 | 0.235000 | -0.270000 | -0.223000 | -0.151000 | 3.49e-01 | 8.47e-02 | 4.71e-02 | 1.02e-01 | 2.67e-01 |
| TRANSLESION SYNTHESIS BY POLH | 19 | 7.15e-02 | 1.46e-01 | 0.4650 | -8.00e-03 | 0.181000 | -0.389000 | -0.125000 | -0.128000 | 9.52e-01 | 1.71e-01 | 3.33e-03 | 3.46e-01 | 3.35e-01 |
| AMINE LIGAND BINDING RECEPTORS | 27 | 2.04e-03 | 8.79e-03 | 0.4650 | -1.41e-01 | 0.071400 | 0.333000 | 0.253000 | 0.128000 | 2.04e-01 | 5.21e-01 | 2.74e-03 | 2.31e-02 | 2.51e-01 |
| NCAM SIGNALING FOR NEURITE OUT GROWTH | 58 | 1.60e-04 | 1.05e-03 | 0.4630 | -2.14e-01 | -0.185000 | 0.301000 | -0.111000 | 0.175000 | 4.87e-03 | 1.47e-02 | 7.25e-05 | 1.43e-01 | 2.10e-02 |
| RA BIOSYNTHESIS PATHWAY | 10 | 3.70e-01 | 4.74e-01 | 0.4620 | 3.47e-01 | 0.142000 | -0.169000 | 0.120000 | -0.173000 | 5.71e-02 | 4.37e-01 | 3.54e-01 | 5.11e-01 | 3.43e-01 |
| COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES | 59 | 1.00e-07 | 1.32e-06 | 0.4620 | -3.89e-02 | -0.251000 | 0.342000 | -0.177000 | -0.012900 | 6.05e-01 | 8.50e-04 | 5.43e-06 | 1.85e-02 | 8.64e-01 |
| REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 1.54e-06 | 1.70e-05 | 0.4620 | 2.16e-01 | 0.179000 | -0.287000 | -0.120000 | -0.195000 | 6.29e-04 | 4.49e-03 | 5.48e-06 | 5.82e-02 | 2.07e-03 |
| PYROPTOSIS | 20 | 1.59e-01 | 2.60e-01 | 0.4620 | 8.16e-02 | 0.275000 | -0.303000 | -0.094200 | -0.174000 | 5.28e-01 | 3.34e-02 | 1.88e-02 | 4.66e-01 | 1.79e-01 |
| COMMON PATHWAY OF FIBRIN CLOT FORMATION | 11 | 1.93e-01 | 2.96e-01 | 0.4610 | -3.67e-02 | 0.362000 | -0.283000 | 0.022300 | 0.007860 | 8.33e-01 | 3.77e-02 | 1.05e-01 | 8.98e-01 | 9.64e-01 |
| SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL | 13 | 1.24e-01 | 2.18e-01 | 0.4610 | -2.91e-01 | -0.021400 | 0.320000 | 0.136000 | 0.081900 | 6.93e-02 | 8.94e-01 | 4.59e-02 | 3.96e-01 | 6.09e-01 |
| THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS | 25 | 2.63e-02 | 6.73e-02 | 0.4600 | 1.23e-02 | 0.267000 | -0.091400 | 0.362000 | -0.032600 | 9.15e-01 | 2.11e-02 | 4.29e-01 | 1.74e-03 | 7.78e-01 |
| HYALURONAN UPTAKE AND DEGRADATION | 11 | 3.11e-01 | 4.18e-01 | 0.4600 | 2.07e-01 | 0.271000 | -0.055700 | 0.279000 | 0.118000 | 2.36e-01 | 1.19e-01 | 7.49e-01 | 1.09e-01 | 4.97e-01 |
| SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 18 | 1.04e-02 | 3.24e-02 | 0.4590 | -1.20e-01 | -0.148000 | -0.045200 | 0.363000 | -0.201000 | 3.78e-01 | 2.76e-01 | 7.40e-01 | 7.66e-03 | 1.39e-01 |
| TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS | 41 | 4.03e-04 | 2.24e-03 | 0.4590 | -3.60e-01 | -0.119000 | 0.186000 | 0.178000 | -0.002560 | 6.54e-05 | 1.87e-01 | 3.90e-02 | 4.88e-02 | 9.77e-01 |
| PI 3K CASCADE FGFR2 | 15 | 1.42e-01 | 2.41e-01 | 0.4580 | -6.76e-02 | 0.319000 | -0.159000 | -0.028900 | -0.278000 | 6.50e-01 | 3.23e-02 | 2.87e-01 | 8.47e-01 | 6.28e-02 |
| CARNITINE METABOLISM | 14 | 8.31e-02 | 1.63e-01 | 0.4580 | 5.37e-02 | 0.099200 | 0.230000 | 0.377000 | -0.036900 | 7.28e-01 | 5.21e-01 | 1.36e-01 | 1.45e-02 | 8.11e-01 |
| DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM | 39 | 2.84e-04 | 1.66e-03 | 0.4570 | 2.87e-01 | 0.105000 | 0.054500 | 0.090700 | 0.323000 | 1.93e-03 | 2.59e-01 | 5.56e-01 | 3.27e-01 | 4.85e-04 |
| NS1 MEDIATED EFFECTS ON HOST PATHWAYS | 37 | 7.87e-04 | 4.09e-03 | 0.4570 | -3.60e-01 | -0.125000 | 0.118000 | 0.220000 | -0.026800 | 1.52e-04 | 1.87e-01 | 2.14e-01 | 2.03e-02 | 7.78e-01 |
| ATF6 ATF6 ALPHA ACTIVATES CHAPERONES | 12 | 3.37e-01 | 4.42e-01 | 0.4550 | 1.56e-01 | 0.349000 | -0.057800 | 0.222000 | -0.091200 | 3.50e-01 | 3.61e-02 | 7.29e-01 | 1.82e-01 | 5.85e-01 |
| RIP MEDIATED NFKB ACTIVATION VIA ZBP1 | 15 | 6.74e-02 | 1.40e-01 | 0.4550 | 3.90e-01 | -0.014400 | 0.205000 | 0.073200 | 0.087500 | 8.92e-03 | 9.23e-01 | 1.70e-01 | 6.24e-01 | 5.57e-01 |
| SUMOYLATION OF SUMOYLATION PROTEINS | 33 | 2.05e-03 | 8.80e-03 | 0.4550 | -3.78e-01 | -0.078100 | 0.143000 | 0.192000 | -0.018200 | 1.73e-04 | 4.38e-01 | 1.56e-01 | 5.58e-02 | 8.57e-01 |
| P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | 12 | 9.39e-02 | 1.78e-01 | 0.4540 | -5.85e-03 | 0.253000 | 0.209000 | 0.183000 | 0.256000 | 9.72e-01 | 1.29e-01 | 2.11e-01 | 2.73e-01 | 1.25e-01 |
| SIGNALING BY THE B CELL RECEPTOR BCR | 103 | 1.52e-06 | 1.69e-05 | 0.4540 | 1.71e-01 | 0.297000 | -0.240000 | 0.040300 | -0.170000 | 2.71e-03 | 1.93e-07 | 2.55e-05 | 4.80e-01 | 2.92e-03 |
| INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION | 12 | 2.68e-01 | 3.78e-01 | 0.4530 | 1.93e-01 | 0.270000 | -0.233000 | -0.201000 | -0.015800 | 2.46e-01 | 1.05e-01 | 1.63e-01 | 2.28e-01 | 9.24e-01 |
| CYTOSOLIC TRNA AMINOACYLATION | 24 | 9.17e-02 | 1.76e-01 | 0.4530 | -1.33e-01 | 0.202000 | -0.216000 | 0.195000 | -0.249000 | 2.61e-01 | 8.64e-02 | 6.68e-02 | 9.84e-02 | 3.50e-02 |
| DERMATAN SULFATE BIOSYNTHESIS | 11 | 2.69e-01 | 3.79e-01 | 0.4520 | 2.03e-01 | 0.268000 | 0.033800 | 0.216000 | 0.209000 | 2.43e-01 | 1.24e-01 | 8.46e-01 | 2.15e-01 | 2.30e-01 |
| ARACHIDONIC ACID METABOLISM | 38 | 3.04e-03 | 1.25e-02 | 0.4520 | 3.33e-01 | 0.266000 | -0.136000 | -0.051200 | -0.039100 | 3.83e-04 | 4.53e-03 | 1.46e-01 | 5.85e-01 | 6.77e-01 |
| CELLULAR HEXOSE TRANSPORT | 11 | 4.30e-01 | 5.24e-01 | 0.4520 | 2.88e-02 | -0.117000 | 0.310000 | 0.220000 | 0.214000 | 8.69e-01 | 5.02e-01 | 7.55e-02 | 2.06e-01 | 2.20e-01 |
| PIWI INTERACTING RNA PIRNA BIOGENESIS | 17 | 1.35e-01 | 2.32e-01 | 0.4520 | 8.88e-02 | 0.081600 | -0.229000 | -0.248000 | -0.275000 | 5.26e-01 | 5.60e-01 | 1.02e-01 | 7.64e-02 | 4.99e-02 |
| REGULATION OF BACH1 ACTIVITY | 11 | 5.41e-01 | 6.23e-01 | 0.4510 | -8.29e-02 | 0.198000 | -0.297000 | 0.112000 | -0.238000 | 6.34e-01 | 2.56e-01 | 8.81e-02 | 5.20e-01 | 1.72e-01 |
| RHOV GTPASE CYCLE | 32 | 1.54e-03 | 7.03e-03 | 0.4510 | -1.30e-01 | -0.129000 | 0.150000 | 0.325000 | 0.203000 | 2.03e-01 | 2.08e-01 | 1.42e-01 | 1.44e-03 | 4.67e-02 |
| SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER | 15 | 2.84e-01 | 3.95e-01 | 0.4510 | 4.98e-02 | -0.090000 | 0.249000 | 0.071300 | 0.354000 | 7.39e-01 | 5.46e-01 | 9.45e-02 | 6.32e-01 | 1.76e-02 |
| KILLING MECHANISMS | 10 | 5.04e-01 | 5.92e-01 | 0.4490 | 2.65e-02 | -0.330000 | 0.189000 | -0.214000 | 0.102000 | 8.85e-01 | 7.06e-02 | 2.99e-01 | 2.42e-01 | 5.77e-01 |
| ABC TRANSPORTERS IN LIPID HOMEOSTASIS | 13 | 1.78e-01 | 2.81e-01 | 0.4490 | -1.77e-01 | 0.083700 | 0.136000 | 0.379000 | 0.018400 | 2.69e-01 | 6.01e-01 | 3.95e-01 | 1.79e-02 | 9.09e-01 |
| KERATAN SULFATE DEGRADATION | 11 | 3.47e-01 | 4.51e-01 | 0.4490 | 3.90e-01 | 0.172000 | -0.103000 | 0.040900 | 0.082300 | 2.49e-02 | 3.22e-01 | 5.56e-01 | 8.14e-01 | 6.36e-01 |
| FGFR2 MUTANT RECEPTOR ACTIVATION | 25 | 1.79e-02 | 5.01e-02 | 0.4480 | 8.56e-02 | 0.167000 | -0.171000 | -0.199000 | -0.311000 | 4.59e-01 | 1.49e-01 | 1.38e-01 | 8.47e-02 | 7.18e-03 |
| BIOLOGICAL OXIDATIONS | 120 | 4.82e-09 | 8.87e-08 | 0.4480 | 2.77e-01 | 0.293000 | -0.139000 | 0.101000 | -0.092400 | 1.71e-07 | 3.02e-08 | 8.51e-03 | 5.53e-02 | 8.08e-02 |
| RHOB GTPASE CYCLE | 67 | 8.11e-06 | 7.52e-05 | 0.4480 | -8.90e-02 | -0.041700 | 0.285000 | 0.237000 | 0.231000 | 2.08e-01 | 5.56e-01 | 5.37e-05 | 8.05e-04 | 1.09e-03 |
| INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | 34 | 1.76e-03 | 7.80e-03 | 0.4440 | -3.68e-01 | -0.042100 | 0.121000 | 0.208000 | -0.047300 | 2.05e-04 | 6.71e-01 | 2.21e-01 | 3.59e-02 | 6.33e-01 |
| TRIGLYCERIDE METABOLISM | 22 | 1.15e-01 | 2.07e-01 | 0.4440 | 9.48e-02 | 0.350000 | -0.207000 | 0.140000 | -0.062500 | 4.42e-01 | 4.53e-03 | 9.35e-02 | 2.57e-01 | 6.12e-01 |
| RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES | 20 | 1.34e-01 | 2.30e-01 | 0.4430 | -2.85e-01 | -0.185000 | 0.255000 | 0.091600 | 0.085700 | 2.74e-02 | 1.52e-01 | 4.87e-02 | 4.78e-01 | 5.07e-01 |
| NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION | 21 | 4.72e-02 | 1.09e-01 | 0.4430 | -1.65e-01 | -0.118000 | 0.349000 | 0.172000 | 0.059200 | 1.92e-01 | 3.49e-01 | 5.58e-03 | 1.73e-01 | 6.39e-01 |
| PEROXISOMAL PROTEIN IMPORT | 57 | 2.52e-04 | 1.53e-03 | 0.4430 | 2.67e-01 | 0.218000 | -0.121000 | 0.218000 | -0.124000 | 5.02e-04 | 4.43e-03 | 1.13e-01 | 4.51e-03 | 1.06e-01 |
| TNFR2 NON CANONICAL NF KB PATHWAY | 78 | 4.69e-05 | 3.60e-04 | 0.4420 | 2.50e-01 | 0.254000 | -0.232000 | 0.027000 | -0.119000 | 1.38e-04 | 1.05e-04 | 4.06e-04 | 6.80e-01 | 7.04e-02 |
| TCR SIGNALING | 99 | 2.53e-06 | 2.62e-05 | 0.4420 | 2.13e-01 | 0.254000 | -0.216000 | 0.020100 | -0.196000 | 2.49e-04 | 1.28e-05 | 2.08e-04 | 7.30e-01 | 7.72e-04 |
| RHOBTB2 GTPASE CYCLE | 23 | 1.96e-01 | 2.98e-01 | 0.4410 | 1.07e-01 | 0.295000 | -0.244000 | 0.120000 | -0.150000 | 3.76e-01 | 1.44e-02 | 4.26e-02 | 3.18e-01 | 2.13e-01 |
| INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS | 35 | 1.68e-03 | 7.54e-03 | 0.4410 | -3.51e-01 | -0.053900 | 0.114000 | 0.230000 | -0.054600 | 3.32e-04 | 5.81e-01 | 2.43e-01 | 1.83e-02 | 5.76e-01 |
| DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS | 48 | 6.49e-03 | 2.21e-02 | 0.4410 | -8.58e-02 | -0.211000 | 0.325000 | -0.038400 | 0.188000 | 3.04e-01 | 1.17e-02 | 9.93e-05 | 6.46e-01 | 2.39e-02 |
| EPHRIN SIGNALING | 19 | 1.22e-02 | 3.66e-02 | 0.4410 | -1.27e-01 | 0.220000 | 0.033200 | 0.275000 | 0.229000 | 3.37e-01 | 9.63e-02 | 8.02e-01 | 3.79e-02 | 8.35e-02 |
| INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | 28 | 5.86e-02 | 1.26e-01 | 0.4410 | 1.70e-01 | 0.133000 | -0.276000 | -0.022600 | -0.266000 | 1.19e-01 | 2.24e-01 | 1.16e-02 | 8.36e-01 | 1.47e-02 |
| TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | 17 | 1.79e-01 | 2.82e-01 | 0.4400 | -3.11e-01 | -0.252000 | 0.147000 | 0.078900 | 0.077400 | 2.65e-02 | 7.18e-02 | 2.95e-01 | 5.73e-01 | 5.81e-01 |
| RET SIGNALING | 36 | 2.10e-04 | 1.31e-03 | 0.4390 | -2.96e-01 | 0.032400 | 0.252000 | 0.038900 | 0.198000 | 2.11e-03 | 7.37e-01 | 8.84e-03 | 6.86e-01 | 3.98e-02 |
| PROCESSING OF INTRONLESS PRE MRNAS | 19 | 7.08e-02 | 1.46e-01 | 0.4390 | -3.14e-01 | -0.129000 | -0.041400 | -0.032600 | -0.274000 | 1.78e-02 | 3.31e-01 | 7.55e-01 | 8.06e-01 | 3.89e-02 |
| CHAPERONE MEDIATED AUTOPHAGY | 19 | 9.22e-02 | 1.77e-01 | 0.4380 | 5.48e-02 | 0.264000 | -0.341000 | -0.032600 | -0.040800 | 6.79e-01 | 4.64e-02 | 1.01e-02 | 8.06e-01 | 7.58e-01 |
| DAG AND IP3 SIGNALING | 40 | 8.19e-04 | 4.21e-03 | 0.4370 | -2.40e-01 | -0.015500 | 0.214000 | 0.250000 | 0.156000 | 8.53e-03 | 8.65e-01 | 1.94e-02 | 6.23e-03 | 8.72e-02 |
| RAB GERANYLGERANYLATION | 57 | 2.00e-03 | 8.66e-03 | 0.4360 | -8.47e-02 | 0.217000 | -0.233000 | 0.136000 | -0.252000 | 2.69e-01 | 4.62e-03 | 2.32e-03 | 7.68e-02 | 1.01e-03 |
| BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS | 11 | 3.63e-01 | 4.67e-01 | 0.4360 | 3.13e-01 | 0.044600 | 0.111000 | 0.123000 | 0.250000 | 7.20e-02 | 7.98e-01 | 5.24e-01 | 4.80e-01 | 1.51e-01 |
| MOLECULES ASSOCIATED WITH ELASTIC FIBRES | 31 | 6.20e-03 | 2.13e-02 | 0.4360 | 2.85e-01 | 0.092700 | 0.072900 | 0.020800 | 0.306000 | 5.95e-03 | 3.72e-01 | 4.82e-01 | 8.41e-01 | 3.15e-03 |
| PHASE 4 RESTING MEMBRANE POTENTIAL | 14 | 9.25e-02 | 1.77e-01 | 0.4350 | -4.24e-01 | 0.017000 | 0.060000 | -0.076900 | 0.000225 | 6.08e-03 | 9.12e-01 | 6.98e-01 | 6.19e-01 | 9.99e-01 |
| IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | 42 | 4.73e-04 | 2.59e-03 | 0.4350 | 3.56e-01 | 0.087200 | -0.058200 | -0.184000 | 0.132000 | 6.69e-05 | 3.28e-01 | 5.14e-01 | 3.87e-02 | 1.39e-01 |
| INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE | 22 | 1.56e-01 | 2.56e-01 | 0.4340 | 1.36e-01 | 0.299000 | -0.170000 | 0.218000 | -0.063300 | 2.69e-01 | 1.52e-02 | 1.69e-01 | 7.64e-02 | 6.07e-01 |
| SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS | 11 | 3.83e-01 | 4.82e-01 | 0.4330 | 1.18e-01 | 0.034600 | 0.184000 | 0.165000 | 0.333000 | 5.00e-01 | 8.42e-01 | 2.91e-01 | 3.42e-01 | 5.59e-02 |
| DEFECTIVE EXT2 CAUSES EXOSTOSES 2 | 14 | 2.64e-01 | 3.73e-01 | 0.4320 | 1.53e-01 | 0.000334 | 0.175000 | 0.004080 | 0.364000 | 3.22e-01 | 9.98e-01 | 2.56e-01 | 9.79e-01 | 1.82e-02 |
| APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B | 21 | 1.83e-01 | 2.85e-01 | 0.4320 | 1.23e-01 | 0.130000 | -0.320000 | -0.032600 | -0.227000 | 3.31e-01 | 3.04e-01 | 1.13e-02 | 7.96e-01 | 7.15e-02 |
| GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | 23 | 5.19e-02 | 1.16e-01 | 0.4310 | -2.82e-01 | -0.121000 | 0.184000 | 0.233000 | 0.061900 | 1.91e-02 | 3.17e-01 | 1.27e-01 | 5.35e-02 | 6.07e-01 |
| SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL | 10 | 2.72e-01 | 3.82e-01 | 0.4310 | 1.47e-02 | 0.214000 | 0.179000 | 0.325000 | -0.039700 | 9.36e-01 | 2.40e-01 | 3.26e-01 | 7.50e-02 | 8.28e-01 |
| TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY | 29 | 2.30e-02 | 6.06e-02 | 0.4310 | 2.52e-01 | 0.011400 | 0.173000 | 0.118000 | 0.279000 | 1.88e-02 | 9.15e-01 | 1.06e-01 | 2.70e-01 | 9.42e-03 |
| MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | 31 | 6.66e-03 | 2.25e-02 | 0.4310 | -2.91e-01 | 0.030600 | -0.002020 | 0.224000 | -0.222000 | 4.99e-03 | 7.68e-01 | 9.84e-01 | 3.08e-02 | 3.24e-02 |
| INTERLEUKIN 15 SIGNALING | 12 | 2.00e-01 | 3.03e-01 | 0.4310 | -2.92e-01 | -0.025100 | 0.179000 | -0.073800 | 0.249000 | 8.03e-02 | 8.80e-01 | 2.82e-01 | 6.58e-01 | 1.35e-01 |
| IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS | 12 | 1.10e-01 | 2.01e-01 | 0.4300 | 2.88e-01 | 0.007680 | 0.269000 | 0.173000 | -0.000831 | 8.41e-02 | 9.63e-01 | 1.07e-01 | 3.01e-01 | 9.96e-01 |
| PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR | 20 | 2.31e-01 | 3.41e-01 | 0.4290 | 4.22e-02 | 0.235000 | -0.300000 | -0.088500 | -0.170000 | 7.44e-01 | 6.93e-02 | 2.02e-02 | 4.93e-01 | 1.87e-01 |
| ACTIVATION OF RAC1 | 13 | 1.66e-01 | 2.68e-01 | 0.4280 | -2.00e-01 | 0.178000 | -0.243000 | 0.223000 | -0.053600 | 2.11e-01 | 2.66e-01 | 1.30e-01 | 1.64e-01 | 7.38e-01 |
| TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA | 34 | 6.13e-03 | 2.12e-02 | 0.4280 | -3.24e-01 | -0.117000 | 0.168000 | 0.189000 | 0.000290 | 1.07e-03 | 2.36e-01 | 8.99e-02 | 5.61e-02 | 9.98e-01 |
| PHOSPHORYLATION OF THE APC C | 17 | 1.67e-01 | 2.68e-01 | 0.4280 | 9.53e-02 | 0.033700 | -0.325000 | -0.010800 | -0.258000 | 4.96e-01 | 8.10e-01 | 2.02e-02 | 9.38e-01 | 6.56e-02 |
| RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX | 28 | 1.38e-01 | 2.35e-01 | 0.4260 | 6.38e-02 | 0.236000 | -0.290000 | -0.016800 | -0.194000 | 5.59e-01 | 3.10e-02 | 7.86e-03 | 8.78e-01 | 7.60e-02 |
| ELEVATION OF CYTOSOLIC CA2 LEVELS | 14 | 2.93e-01 | 4.03e-01 | 0.4250 | -3.92e-02 | -0.156000 | 0.237000 | 0.265000 | 0.169000 | 7.99e-01 | 3.11e-01 | 1.25e-01 | 8.61e-02 | 2.74e-01 |
| FORMATION OF FIBRIN CLOT CLOTTING CASCADE | 20 | 1.47e-01 | 2.46e-01 | 0.4250 | 1.10e-01 | 0.316000 | -0.255000 | -0.037700 | -0.048800 | 3.94e-01 | 1.46e-02 | 4.87e-02 | 7.70e-01 | 7.06e-01 |
| TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST | 15 | 2.35e-01 | 3.46e-01 | 0.4240 | -9.43e-03 | -0.122000 | 0.342000 | 0.185000 | 0.116000 | 9.50e-01 | 4.14e-01 | 2.20e-02 | 2.15e-01 | 4.35e-01 |
| ELASTIC FIBRE FORMATION | 35 | 3.41e-03 | 1.36e-02 | 0.4240 | 2.18e-01 | 0.112000 | 0.129000 | 0.014200 | 0.320000 | 2.56e-02 | 2.51e-01 | 1.86e-01 | 8.85e-01 | 1.06e-03 |
| CELL EXTRACELLULAR MATRIX INTERACTIONS | 18 | 2.50e-02 | 6.49e-02 | 0.4230 | 2.15e-01 | 0.312000 | 0.101000 | 0.122000 | -0.102000 | 1.14e-01 | 2.19e-02 | 4.60e-01 | 3.72e-01 | 4.56e-01 |
| RHOU GTPASE CYCLE | 33 | 5.63e-03 | 2.00e-02 | 0.4220 | -1.43e-01 | -0.033300 | 0.169000 | 0.296000 | 0.201000 | 1.56e-01 | 7.41e-01 | 9.30e-02 | 3.23e-03 | 4.52e-02 |
| GLUCONEOGENESIS | 27 | 2.07e-02 | 5.58e-02 | 0.4220 | -2.67e-02 | 0.367000 | -0.087600 | 0.138000 | -0.124000 | 8.11e-01 | 9.53e-04 | 4.31e-01 | 2.13e-01 | 2.65e-01 |
| ROS AND RNS PRODUCTION IN PHAGOCYTES | 28 | 7.65e-02 | 1.53e-01 | 0.4220 | 1.21e-01 | 0.306000 | -0.251000 | -0.008350 | -0.079100 | 2.68e-01 | 5.09e-03 | 2.14e-02 | 9.39e-01 | 4.69e-01 |
| ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA | 15 | 1.93e-01 | 2.96e-01 | 0.4220 | -2.32e-01 | 0.152000 | -0.275000 | 0.076500 | -0.138000 | 1.19e-01 | 3.07e-01 | 6.51e-02 | 6.08e-01 | 3.56e-01 |
| SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS | 12 | 2.08e-01 | 3.13e-01 | 0.4210 | -9.59e-02 | 0.326000 | -0.233000 | 0.086200 | 0.011700 | 5.65e-01 | 5.03e-02 | 1.62e-01 | 6.05e-01 | 9.44e-01 |
| MITOTIC G1 PHASE AND G1 S TRANSITION | 140 | 6.40e-08 | 8.95e-07 | 0.4210 | 1.61e-01 | 0.203000 | -0.229000 | 0.093000 | -0.222000 | 1.06e-03 | 3.50e-05 | 2.90e-06 | 5.79e-02 | 5.61e-06 |
| MAPK6 MAPK4 SIGNALING | 83 | 2.50e-05 | 2.13e-04 | 0.4210 | 2.37e-01 | 0.231000 | -0.197000 | -0.053100 | -0.162000 | 1.94e-04 | 2.78e-04 | 1.95e-03 | 4.04e-01 | 1.06e-02 |
| RESOLUTION OF D LOOP STRUCTURES | 30 | 1.21e-02 | 3.63e-02 | 0.4200 | -3.08e-01 | -0.187000 | 0.045700 | -0.080900 | -0.196000 | 3.50e-03 | 7.69e-02 | 6.65e-01 | 4.43e-01 | 6.32e-02 |
| CA DEPENDENT EVENTS | 36 | 1.97e-03 | 8.56e-03 | 0.4200 | -2.14e-01 | 0.054200 | 0.159000 | 0.303000 | 0.099500 | 2.60e-02 | 5.74e-01 | 9.80e-02 | 1.63e-03 | 3.02e-01 |
| RETROGRADE NEUROTROPHIN SIGNALLING | 13 | 2.49e-01 | 3.59e-01 | 0.4200 | -1.42e-01 | 0.039700 | 0.092500 | 0.381000 | -0.031400 | 3.77e-01 | 8.04e-01 | 5.64e-01 | 1.75e-02 | 8.45e-01 |
| INOSITOL PHOSPHATE METABOLISM | 46 | 2.53e-04 | 1.53e-03 | 0.4190 | -1.18e-01 | 0.057800 | 0.266000 | 0.261000 | 0.140000 | 1.68e-01 | 4.98e-01 | 1.78e-03 | 2.22e-03 | 1.00e-01 |
| ANTIMICROBIAL PEPTIDES | 13 | 4.01e-01 | 4.98e-01 | 0.4190 | 2.93e-01 | 0.270000 | -0.111000 | 0.012100 | -0.067600 | 6.71e-02 | 9.23e-02 | 4.89e-01 | 9.40e-01 | 6.73e-01 |
| SUMOYLATION OF RNA BINDING PROTEINS | 45 | 3.42e-04 | 1.95e-03 | 0.4190 | -3.75e-01 | -0.039200 | 0.114000 | 0.137000 | -0.039400 | 1.33e-05 | 6.49e-01 | 1.86e-01 | 1.13e-01 | 6.48e-01 |
| RESPONSE OF MTB TO PHAGOCYTOSIS | 21 | 1.23e-01 | 2.17e-01 | 0.4190 | 5.93e-02 | 0.334000 | -0.107000 | 0.219000 | -0.023600 | 6.38e-01 | 7.99e-03 | 3.95e-01 | 8.22e-02 | 8.52e-01 |
| DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 | 17 | 7.24e-02 | 1.48e-01 | 0.4190 | 6.25e-02 | 0.396000 | -0.113000 | 0.024400 | 0.035300 | 6.56e-01 | 4.69e-03 | 4.22e-01 | 8.62e-01 | 8.01e-01 |
| IRF3 MEDIATED INDUCTION OF TYPE I IFN | 11 | 2.62e-01 | 3.72e-01 | 0.4180 | 7.39e-02 | -0.299000 | 0.199000 | -0.196000 | -0.047800 | 6.71e-01 | 8.61e-02 | 2.53e-01 | 2.61e-01 | 7.84e-01 |
| FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF | 13 | 1.83e-01 | 2.86e-01 | 0.4180 | -3.36e-01 | -0.201000 | 0.010100 | 0.013500 | 0.145000 | 3.58e-02 | 2.09e-01 | 9.50e-01 | 9.33e-01 | 3.65e-01 |
| METALLOPROTEASE DUBS | 24 | 1.40e-01 | 2.37e-01 | 0.4180 | 1.66e-02 | 0.219000 | -0.191000 | -0.015500 | -0.300000 | 8.88e-01 | 6.33e-02 | 1.06e-01 | 8.95e-01 | 1.11e-02 |
| VEGFR2 MEDIATED VASCULAR PERMEABILITY | 26 | 4.10e-02 | 9.65e-02 | 0.4170 | 5.88e-02 | 0.246000 | 0.006760 | 0.331000 | 0.027000 | 6.04e-01 | 3.02e-02 | 9.52e-01 | 3.46e-03 | 8.12e-01 |
| RAF ACTIVATION | 34 | 1.06e-02 | 3.28e-02 | 0.4170 | -7.03e-02 | 0.273000 | -0.036600 | 0.274000 | -0.136000 | 4.78e-01 | 5.83e-03 | 7.12e-01 | 5.79e-03 | 1.71e-01 |
| GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | 18 | 3.46e-03 | 1.37e-02 | 0.4160 | -2.36e-01 | 0.207000 | -0.110000 | 0.086600 | 0.236000 | 8.37e-02 | 1.29e-01 | 4.20e-01 | 5.25e-01 | 8.35e-02 |
| KSRP KHSRP BINDS AND DESTABILIZES MRNA | 16 | 1.73e-01 | 2.74e-01 | 0.4160 | -1.62e-01 | -0.163000 | 0.080300 | -0.331000 | -0.059700 | 2.61e-01 | 2.58e-01 | 5.78e-01 | 2.19e-02 | 6.79e-01 |
| ABC FAMILY PROTEINS MEDIATED TRANSPORT | 92 | 4.38e-05 | 3.39e-04 | 0.4150 | 1.98e-01 | 0.263000 | -0.222000 | 0.068100 | -0.101000 | 1.06e-03 | 1.34e-05 | 2.28e-04 | 2.60e-01 | 9.50e-02 |
| LYSOSPHINGOLIPID AND LPA RECEPTORS | 11 | 5.34e-02 | 1.18e-01 | 0.4150 | -1.46e-01 | 0.121000 | -0.297000 | -0.135000 | 0.173000 | 4.03e-01 | 4.87e-01 | 8.81e-02 | 4.38e-01 | 3.20e-01 |
| RHO GTPASES ACTIVATE WASPS AND WAVES | 36 | 6.05e-03 | 2.11e-02 | 0.4140 | 6.15e-03 | 0.321000 | -0.030600 | 0.225000 | -0.131000 | 9.49e-01 | 8.67e-04 | 7.50e-01 | 1.96e-02 | 1.74e-01 |
| OLFACTORY SIGNALING PATHWAY | 21 | 2.07e-02 | 5.58e-02 | 0.4140 | 9.93e-03 | 0.078400 | -0.277000 | -0.291000 | 0.063100 | 9.37e-01 | 5.34e-01 | 2.82e-02 | 2.10e-02 | 6.17e-01 |
| RNA POLYMERASE III TRANSCRIPTION TERMINATION | 23 | 5.38e-02 | 1.19e-01 | 0.4140 | 7.26e-03 | -0.079500 | -0.170000 | -0.355000 | -0.098700 | 9.52e-01 | 5.09e-01 | 1.59e-01 | 3.19e-03 | 4.13e-01 |
| PKA MEDIATED PHOSPHORYLATION OF CREB | 19 | 1.70e-02 | 4.83e-02 | 0.4140 | -2.36e-01 | 0.174000 | 0.112000 | 0.172000 | 0.208000 | 7.44e-02 | 1.90e-01 | 4.00e-01 | 1.95e-01 | 1.17e-01 |
| G2 M CHECKPOINTS | 130 | 3.16e-07 | 3.86e-06 | 0.4140 | 1.06e-01 | 0.156000 | -0.276000 | -0.040100 | -0.240000 | 3.75e-02 | 2.13e-03 | 5.72e-08 | 4.30e-01 | 2.29e-06 |
| BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION | 26 | 4.09e-02 | 9.65e-02 | 0.4130 | 3.79e-02 | -0.065400 | 0.359000 | 0.083500 | 0.170000 | 7.38e-01 | 5.64e-01 | 1.52e-03 | 4.61e-01 | 1.33e-01 |
| RHO GTPASES ACTIVATE KTN1 | 11 | 6.76e-01 | 7.31e-01 | 0.4130 | 1.61e-01 | 0.269000 | -0.187000 | 0.139000 | -0.135000 | 3.55e-01 | 1.23e-01 | 2.83e-01 | 4.24e-01 | 4.38e-01 |
| NETRIN 1 SIGNALING | 48 | 1.54e-03 | 7.03e-03 | 0.4120 | -2.60e-01 | -0.102000 | 0.213000 | 0.149000 | 0.155000 | 1.81e-03 | 2.20e-01 | 1.07e-02 | 7.33e-02 | 6.28e-02 |
| RHO GTPASES ACTIVATE CIT | 18 | 1.23e-01 | 2.17e-01 | 0.4120 | 2.99e-01 | 0.216000 | -0.075500 | -0.149000 | 0.076900 | 2.82e-02 | 1.13e-01 | 5.79e-01 | 2.75e-01 | 5.72e-01 |
| ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS | 19 | 9.52e-02 | 1.80e-01 | 0.4120 | 1.21e-01 | 0.020400 | -0.270000 | 0.116000 | -0.261000 | 3.62e-01 | 8.77e-01 | 4.15e-02 | 3.83e-01 | 4.89e-02 |
| SIGNALING BY FGFR4 IN DISEASE | 10 | 3.70e-01 | 4.74e-01 | 0.4110 | -4.48e-02 | 0.307000 | -0.254000 | -0.087900 | -0.023100 | 8.06e-01 | 9.24e-02 | 1.64e-01 | 6.30e-01 | 9.00e-01 |
| LONG TERM POTENTIATION | 23 | 7.92e-02 | 1.57e-01 | 0.4110 | -2.07e-01 | -0.147000 | 0.299000 | 0.118000 | 0.038100 | 8.64e-02 | 2.22e-01 | 1.31e-02 | 3.26e-01 | 7.52e-01 |
| DNA METHYLATION | 19 | 6.67e-02 | 1.39e-01 | 0.4110 | 2.07e-01 | -0.006140 | -0.016600 | -0.355000 | -0.012200 | 1.18e-01 | 9.63e-01 | 9.01e-01 | 7.47e-03 | 9.27e-01 |
| G PROTEIN MEDIATED EVENTS | 52 | 5.06e-05 | 3.83e-04 | 0.4110 | -1.73e-01 | 0.085100 | 0.140000 | 0.301000 | 0.146000 | 3.12e-02 | 2.89e-01 | 8.05e-02 | 1.74e-04 | 6.78e-02 |
| CHONDROITIN SULFATE BIOSYNTHESIS | 18 | 1.70e-01 | 2.70e-01 | 0.4090 | 2.44e-01 | 0.065600 | 0.149000 | 0.211000 | 0.192000 | 7.37e-02 | 6.30e-01 | 2.73e-01 | 1.20e-01 | 1.59e-01 |
| MATURATION OF SARS COV 2 SPIKE PROTEIN | 29 | 1.71e-02 | 4.83e-02 | 0.4090 | 1.77e-01 | 0.250000 | 0.085400 | 0.210000 | 0.149000 | 9.91e-02 | 1.99e-02 | 4.26e-01 | 5.06e-02 | 1.65e-01 |
| DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 | 19 | 3.85e-02 | 9.17e-02 | 0.4080 | 5.63e-02 | 0.396000 | -0.061500 | 0.035500 | 0.040700 | 6.71e-01 | 2.84e-03 | 6.43e-01 | 7.89e-01 | 7.59e-01 |
| INSULIN PROCESSING | 24 | 6.65e-03 | 2.25e-02 | 0.4080 | -1.49e-01 | 0.087200 | -0.156000 | 0.333000 | 0.035900 | 2.05e-01 | 4.60e-01 | 1.86e-01 | 4.79e-03 | 7.61e-01 |
| WNT LIGAND BIOGENESIS AND TRAFFICKING | 18 | 2.32e-01 | 3.41e-01 | 0.4070 | -3.89e-02 | 0.223000 | -0.159000 | 0.287000 | -0.085500 | 7.75e-01 | 1.02e-01 | 2.44e-01 | 3.51e-02 | 5.30e-01 |
| INACTIVATION OF CSF3 G CSF SIGNALING | 24 | 1.47e-01 | 2.45e-01 | 0.4070 | 1.97e-01 | 0.241000 | -0.219000 | -0.107000 | -0.096800 | 9.42e-02 | 4.07e-02 | 6.39e-02 | 3.66e-01 | 4.12e-01 |
| ERYTHROPOIETIN ACTIVATES RAS | 13 | 3.06e-01 | 4.15e-01 | 0.4070 | 1.39e-01 | 0.355000 | -0.045300 | 0.131000 | 0.026000 | 3.84e-01 | 2.67e-02 | 7.77e-01 | 4.13e-01 | 8.71e-01 |
| INTERLEUKIN 1 SIGNALING | 95 | 2.42e-05 | 2.09e-04 | 0.4060 | 2.20e-01 | 0.258000 | -0.165000 | 0.047800 | -0.144000 | 2.09e-04 | 1.42e-05 | 5.39e-03 | 4.21e-01 | 1.56e-02 |
| PHASE I FUNCTIONALIZATION OF COMPOUNDS | 57 | 7.77e-04 | 4.08e-03 | 0.4060 | 2.90e-01 | 0.251000 | -0.083600 | 0.097900 | 0.031300 | 1.55e-04 | 1.04e-03 | 2.75e-01 | 2.01e-01 | 6.83e-01 |
| DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | 36 | 2.86e-02 | 7.12e-02 | 0.4060 | 1.77e-01 | 0.117000 | -0.266000 | -0.141000 | -0.170000 | 6.58e-02 | 2.24e-01 | 5.77e-03 | 1.43e-01 | 7.78e-02 |
| INTERLEUKIN 20 FAMILY SIGNALING | 12 | 4.51e-01 | 5.43e-01 | 0.4060 | 1.42e-01 | -0.023500 | 0.296000 | 0.051700 | 0.231000 | 3.96e-01 | 8.88e-01 | 7.55e-02 | 7.56e-01 | 1.66e-01 |
| APOPTOTIC FACTOR MEDIATED RESPONSE | 18 | 3.25e-01 | 4.28e-01 | 0.4060 | 2.17e-01 | 0.153000 | -0.237000 | -0.043700 | -0.189000 | 1.10e-01 | 2.60e-01 | 8.19e-02 | 7.48e-01 | 1.65e-01 |
| RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY | 14 | 4.00e-01 | 4.97e-01 | 0.4050 | -3.81e-02 | 0.301000 | -0.225000 | -0.019700 | -0.146000 | 8.05e-01 | 5.11e-02 | 1.46e-01 | 8.99e-01 | 3.45e-01 |
| INTEGRIN SIGNALING | 24 | 1.69e-02 | 4.81e-02 | 0.4050 | 3.43e-02 | 0.174000 | 0.255000 | 0.168000 | 0.198000 | 7.71e-01 | 1.40e-01 | 3.03e-02 | 1.54e-01 | 9.36e-02 |
| PLATELET ADHESION TO EXPOSED COLLAGEN | 11 | 3.13e-01 | 4.19e-01 | 0.4050 | 6.81e-02 | 0.275000 | -0.260000 | -0.114000 | 0.052300 | 6.96e-01 | 1.14e-01 | 1.35e-01 | 5.13e-01 | 7.64e-01 |
| SIGNALING BY FGFR2 IN DISEASE | 35 | 2.03e-02 | 5.51e-02 | 0.4050 | 4.84e-02 | 0.207000 | -0.195000 | -0.168000 | -0.229000 | 6.20e-01 | 3.39e-02 | 4.57e-02 | 8.63e-02 | 1.93e-02 |
| RAP1 SIGNALLING | 15 | 2.52e-01 | 3.61e-01 | 0.4050 | -1.58e-01 | 0.173000 | -0.004780 | 0.310000 | -0.112000 | 2.89e-01 | 2.45e-01 | 9.74e-01 | 3.77e-02 | 4.53e-01 |
| SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | 11 | 4.15e-01 | 5.13e-01 | 0.4040 | 2.09e-01 | 0.097900 | -0.147000 | -0.294000 | -0.043700 | 2.29e-01 | 5.74e-01 | 3.98e-01 | 9.16e-02 | 8.02e-01 |
| FC EPSILON RECEPTOR FCERI SIGNALING | 123 | 5.55e-06 | 5.50e-05 | 0.4040 | 1.13e-01 | 0.266000 | -0.208000 | 0.062400 | -0.180000 | 3.07e-02 | 3.61e-07 | 7.14e-05 | 2.33e-01 | 5.61e-04 |
| SUMOYLATION OF UBIQUITINYLATION PROTEINS | 37 | 4.30e-03 | 1.62e-02 | 0.4030 | -3.25e-01 | -0.054000 | 0.184000 | 0.143000 | 0.002970 | 6.21e-04 | 5.70e-01 | 5.33e-02 | 1.33e-01 | 9.75e-01 |
| GLUCAGON TYPE LIGAND RECEPTORS | 23 | 1.00e-01 | 1.87e-01 | 0.4030 | 1.76e-01 | 0.232000 | -0.262000 | -0.094200 | -0.000621 | 1.45e-01 | 5.40e-02 | 2.95e-02 | 4.34e-01 | 9.96e-01 |
| ANCHORING FIBRIL FORMATION | 13 | 3.41e-01 | 4.45e-01 | 0.4020 | -1.39e-01 | -0.313000 | 0.175000 | -0.097300 | -0.068800 | 3.87e-01 | 5.07e-02 | 2.75e-01 | 5.44e-01 | 6.68e-01 |
| UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION | 21 | 1.48e-01 | 2.46e-01 | 0.4020 | -2.30e-01 | -0.188000 | 0.258000 | 0.084400 | 0.010000 | 6.86e-02 | 1.36e-01 | 4.09e-02 | 5.03e-01 | 9.37e-01 |
| SYNTHESIS OF BILE ACIDS AND BILE SALTS | 21 | 4.75e-02 | 1.09e-01 | 0.4010 | 6.16e-02 | 0.253000 | 0.132000 | 0.274000 | -0.014800 | 6.25e-01 | 4.45e-02 | 2.95e-01 | 2.96e-02 | 9.07e-01 |
| HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE | 40 | 1.43e-03 | 6.64e-03 | 0.4010 | -1.36e-01 | -0.135000 | -0.214000 | -0.051600 | -0.275000 | 1.37e-01 | 1.40e-01 | 1.90e-02 | 5.72e-01 | 2.65e-03 |
| ACYL CHAIN REMODELLING OF PG | 10 | 4.93e-01 | 5.83e-01 | 0.4010 | 1.83e-01 | 0.121000 | -0.033800 | 0.308000 | -0.128000 | 3.15e-01 | 5.09e-01 | 8.53e-01 | 9.16e-02 | 4.84e-01 |
| ERKS ARE INACTIVATED | 13 | 2.43e-01 | 3.53e-01 | 0.4000 | -1.74e-01 | 0.199000 | 0.066000 | 0.268000 | -0.120000 | 2.77e-01 | 2.14e-01 | 6.80e-01 | 9.44e-02 | 4.55e-01 |
| INFLAMMASOMES | 18 | 3.24e-01 | 4.28e-01 | 0.4000 | 1.53e-01 | 0.304000 | -0.197000 | -0.006250 | -0.076700 | 2.62e-01 | 2.57e-02 | 1.48e-01 | 9.63e-01 | 5.73e-01 |
| PI METABOLISM | 79 | 4.61e-07 | 5.57e-06 | 0.4000 | -1.87e-01 | -0.003510 | 0.250000 | 0.247000 | 0.036400 | 4.08e-03 | 9.57e-01 | 1.20e-04 | 1.47e-04 | 5.76e-01 |
| TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | 16 | 7.07e-02 | 1.46e-01 | 0.3990 | 1.07e-01 | 0.364000 | -0.060100 | -0.109000 | -0.009180 | 4.59e-01 | 1.18e-02 | 6.77e-01 | 4.48e-01 | 9.49e-01 |
| MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | 15 | 2.63e-01 | 3.73e-01 | 0.3990 | -4.24e-02 | -0.207000 | 0.017400 | -0.332000 | -0.063700 | 7.76e-01 | 1.66e-01 | 9.07e-01 | 2.58e-02 | 6.69e-01 |
| MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS | 18 | 2.51e-01 | 3.60e-01 | 0.3980 | -1.83e-02 | -0.147000 | 0.244000 | 0.228000 | 0.160000 | 8.93e-01 | 2.80e-01 | 7.33e-02 | 9.44e-02 | 2.41e-01 |
| LYSOSOME VESICLE BIOGENESIS | 32 | 1.93e-02 | 5.33e-02 | 0.3980 | -9.75e-02 | 0.304000 | -0.141000 | 0.182000 | -0.064200 | 3.40e-01 | 2.96e-03 | 1.68e-01 | 7.53e-02 | 5.30e-01 |
| RND2 GTPASE CYCLE | 38 | 6.09e-03 | 2.12e-02 | 0.3980 | -1.49e-01 | -0.136000 | 0.153000 | 0.188000 | 0.242000 | 1.11e-01 | 1.46e-01 | 1.03e-01 | 4.46e-02 | 9.84e-03 |
| GLUTAMATE AND GLUTAMINE METABOLISM | 13 | 3.32e-01 | 4.37e-01 | 0.3980 | -9.35e-02 | 0.240000 | 0.009890 | 0.297000 | -0.062700 | 5.60e-01 | 1.34e-01 | 9.51e-01 | 6.42e-02 | 6.96e-01 |
| CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | 19 | 2.17e-01 | 3.23e-01 | 0.3980 | 1.54e-01 | 0.073300 | -0.275000 | 0.036500 | -0.228000 | 2.46e-01 | 5.80e-01 | 3.77e-02 | 7.83e-01 | 8.53e-02 |
| TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY | 12 | 4.37e-01 | 5.30e-01 | 0.3980 | 1.82e-01 | -0.039900 | 0.280000 | 0.114000 | 0.178000 | 2.75e-01 | 8.11e-01 | 9.26e-02 | 4.93e-01 | 2.85e-01 |
| SIGNALING BY NOTCH4 | 83 | 1.18e-04 | 8.16e-04 | 0.3980 | 2.27e-01 | 0.247000 | -0.194000 | -0.029900 | -0.084800 | 3.55e-04 | 1.02e-04 | 2.29e-03 | 6.38e-01 | 1.82e-01 |
| TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | 13 | 4.27e-01 | 5.23e-01 | 0.3960 | 1.07e-01 | 0.336000 | -0.164000 | -0.015200 | -0.072200 | 5.04e-01 | 3.59e-02 | 3.07e-01 | 9.24e-01 | 6.52e-01 |
| GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | 14 | 4.22e-01 | 5.19e-01 | 0.3940 | 1.56e-01 | 0.287000 | -0.098400 | 0.196000 | 0.027300 | 3.13e-01 | 6.33e-02 | 5.24e-01 | 2.04e-01 | 8.60e-01 |
| REGULATION OF TNFR1 SIGNALING | 34 | 1.70e-02 | 4.82e-02 | 0.3940 | 2.42e-01 | 0.062600 | 0.104000 | 0.121000 | 0.259000 | 1.45e-02 | 5.28e-01 | 2.94e-01 | 2.21e-01 | 9.08e-03 |
| MATURATION OF NUCLEOPROTEIN | 10 | 5.42e-01 | 6.23e-01 | 0.3940 | -3.19e-01 | -0.133000 | -0.063100 | -0.097700 | -0.148000 | 8.06e-02 | 4.65e-01 | 7.30e-01 | 5.93e-01 | 4.18e-01 |
| SEPARATION OF SISTER CHROMATIDS | 163 | 5.16e-08 | 7.39e-07 | 0.3940 | 8.33e-02 | 0.171000 | -0.247000 | 0.110000 | -0.214000 | 6.68e-02 | 1.67e-04 | 5.77e-08 | 1.56e-02 | 2.40e-06 |
| SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION | 23 | 1.01e-01 | 1.87e-01 | 0.3940 | 1.44e-01 | 0.161000 | -0.177000 | -0.247000 | -0.128000 | 2.32e-01 | 1.82e-01 | 1.42e-01 | 4.07e-02 | 2.89e-01 |
| ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING | 28 | 1.09e-02 | 3.35e-02 | 0.3930 | 1.60e-01 | 0.245000 | -0.223000 | 0.009820 | 0.137000 | 1.43e-01 | 2.47e-02 | 4.12e-02 | 9.28e-01 | 2.10e-01 |
| INTRA GOLGI TRAFFIC | 43 | 1.68e-03 | 7.54e-03 | 0.3920 | -1.07e-01 | 0.007250 | 0.199000 | 0.320000 | 0.011300 | 2.25e-01 | 9.34e-01 | 2.42e-02 | 2.77e-04 | 8.98e-01 |
| METABOLISM OF STEROID HORMONES | 19 | 2.41e-01 | 3.51e-01 | 0.3910 | 2.13e-01 | 0.081100 | -0.251000 | -0.077600 | -0.177000 | 1.07e-01 | 5.41e-01 | 5.80e-02 | 5.58e-01 | 1.81e-01 |
| TRANS GOLGI NETWORK VESICLE BUDDING | 69 | 1.30e-04 | 8.72e-04 | 0.3910 | -8.92e-02 | 0.263000 | -0.137000 | 0.223000 | -0.083600 | 2.01e-01 | 1.62e-04 | 4.93e-02 | 1.35e-03 | 2.30e-01 |
| CD28 CO STIMULATION | 29 | 4.89e-02 | 1.10e-01 | 0.3900 | 2.45e-02 | 0.130000 | -0.057000 | 0.345000 | -0.113000 | 8.20e-01 | 2.25e-01 | 5.95e-01 | 1.31e-03 | 2.93e-01 |
| GOLGI ASSOCIATED VESICLE BIOGENESIS | 54 | 1.34e-03 | 6.35e-03 | 0.3900 | -1.19e-01 | 0.234000 | -0.157000 | 0.222000 | -0.095100 | 1.32e-01 | 2.89e-03 | 4.57e-02 | 4.76e-03 | 2.27e-01 |
| TIE2 SIGNALING | 17 | 3.48e-01 | 4.52e-01 | 0.3890 | 5.38e-02 | 0.307000 | -0.214000 | 0.076900 | -0.054200 | 7.01e-01 | 2.87e-02 | 1.26e-01 | 5.83e-01 | 6.99e-01 |
| SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | 52 | 1.70e-04 | 1.10e-03 | 0.3890 | -1.66e-01 | -0.025800 | 0.274000 | 0.218000 | 0.015100 | 3.83e-02 | 7.48e-01 | 6.23e-04 | 6.61e-03 | 8.51e-01 |
| BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS | 12 | 5.52e-01 | 6.29e-01 | 0.3880 | 2.08e-01 | 0.205000 | -0.204000 | -0.137000 | -0.072900 | 2.13e-01 | 2.20e-01 | 2.21e-01 | 4.10e-01 | 6.62e-01 |
| TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 77 | 4.77e-05 | 3.64e-04 | 0.3880 | 2.11e-02 | -0.015300 | 0.259000 | 0.215000 | 0.192000 | 7.48e-01 | 8.17e-01 | 8.79e-05 | 1.13e-03 | 3.67e-03 |
| HOST INTERACTIONS OF HIV FACTORS | 123 | 2.83e-05 | 2.38e-04 | 0.3880 | 7.43e-02 | 0.234000 | -0.217000 | 0.103000 | -0.181000 | 1.55e-01 | 7.84e-06 | 3.34e-05 | 4.92e-02 | 5.40e-04 |
| LYSINE CATABOLISM | 11 | 3.87e-01 | 4.86e-01 | 0.3880 | 2.91e-01 | 0.076500 | 0.008670 | 0.232000 | -0.074900 | 9.44e-02 | 6.61e-01 | 9.60e-01 | 1.83e-01 | 6.67e-01 |
| JOSEPHIN DOMAIN DUBS | 11 | 3.86e-01 | 4.85e-01 | 0.3870 | 1.01e-01 | 0.350000 | -0.083100 | -0.029200 | -0.097100 | 5.63e-01 | 4.42e-02 | 6.33e-01 | 8.67e-01 | 5.77e-01 |
| RMTS METHYLATE HISTONE ARGININES | 41 | 3.01e-03 | 1.24e-02 | 0.3870 | 7.66e-02 | -0.011300 | 0.193000 | -0.234000 | 0.228000 | 3.96e-01 | 9.00e-01 | 3.24e-02 | 9.42e-03 | 1.17e-02 |
| CDC42 GTPASE CYCLE | 152 | 3.24e-09 | 6.71e-08 | 0.3870 | -6.41e-02 | -0.068100 | 0.288000 | 0.121000 | 0.209000 | 1.73e-01 | 1.48e-01 | 9.23e-10 | 1.01e-02 | 8.80e-06 |
| SIGNALING BY NTRK3 TRKC | 17 | 3.24e-01 | 4.28e-01 | 0.3860 | -8.90e-02 | -0.194000 | 0.099500 | -0.147000 | 0.268000 | 5.25e-01 | 1.66e-01 | 4.77e-01 | 2.94e-01 | 5.55e-02 |
| ACTIVATION OF MATRIX METALLOPROTEINASES | 14 | 2.05e-01 | 3.09e-01 | 0.3850 | -3.52e-01 | 0.005960 | 0.127000 | 0.032800 | -0.088300 | 2.28e-02 | 9.69e-01 | 4.12e-01 | 8.32e-01 | 5.67e-01 |
| ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 | 20 | 7.41e-02 | 1.50e-01 | 0.3850 | 1.07e-01 | 0.130000 | -0.099000 | -0.332000 | 0.018400 | 4.09e-01 | 3.13e-01 | 4.43e-01 | 1.03e-02 | 8.87e-01 |
| O LINKED GLYCOSYLATION OF MUCINS | 37 | 8.24e-03 | 2.71e-02 | 0.3850 | 3.33e-02 | 0.065800 | 0.210000 | 0.302000 | 0.085800 | 7.26e-01 | 4.89e-01 | 2.71e-02 | 1.45e-03 | 3.67e-01 |
| SHC1 EVENTS IN EGFR SIGNALING | 10 | 5.24e-01 | 6.11e-01 | 0.3840 | 1.09e-01 | 0.289000 | -0.177000 | -0.140000 | -0.031600 | 5.50e-01 | 1.13e-01 | 3.31e-01 | 4.44e-01 | 8.63e-01 |
| LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME | 13 | 5.31e-01 | 6.15e-01 | 0.3840 | -1.76e-01 | -0.148000 | 0.156000 | -0.202000 | 0.171000 | 2.72e-01 | 3.55e-01 | 3.31e-01 | 2.08e-01 | 2.85e-01 |
| VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS | 36 | 7.78e-04 | 4.08e-03 | 0.3830 | 5.00e-02 | 0.305000 | -0.121000 | 0.080100 | 0.175000 | 6.03e-01 | 1.55e-03 | 2.11e-01 | 4.06e-01 | 6.95e-02 |
| REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION | 30 | 1.04e-01 | 1.92e-01 | 0.3830 | -8.56e-02 | -0.107000 | 0.225000 | 0.141000 | 0.240000 | 4.17e-01 | 3.12e-01 | 3.26e-02 | 1.80e-01 | 2.31e-02 |
| CD28 DEPENDENT PI3K AKT SIGNALING | 19 | 1.38e-01 | 2.35e-01 | 0.3810 | -6.01e-02 | -0.046900 | 0.165000 | 0.334000 | -0.008680 | 6.50e-01 | 7.23e-01 | 2.12e-01 | 1.16e-02 | 9.48e-01 |
| PROTEIN PROTEIN INTERACTIONS AT SYNAPSES | 85 | 2.62e-04 | 1.58e-03 | 0.3810 | -1.37e-01 | -0.131000 | 0.267000 | 0.082700 | 0.175000 | 2.90e-02 | 3.76e-02 | 2.04e-05 | 1.88e-01 | 5.21e-03 |
| PEXOPHAGY | 11 | 3.63e-01 | 4.67e-01 | 0.3810 | 1.28e-01 | 0.225000 | 0.108000 | 0.096600 | 0.239000 | 4.62e-01 | 1.96e-01 | 5.36e-01 | 5.79e-01 | 1.70e-01 |
| ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES | 48 | 6.40e-05 | 4.68e-04 | 0.3800 | -1.47e-01 | -0.164000 | 0.228000 | -0.177000 | -0.111000 | 7.72e-02 | 4.95e-02 | 6.39e-03 | 3.38e-02 | 1.83e-01 |
| SIGNALING BY RETINOIC ACID | 30 | 1.06e-01 | 1.95e-01 | 0.3790 | 6.09e-02 | 0.274000 | -0.117000 | 0.221000 | -0.049000 | 5.64e-01 | 9.42e-03 | 2.69e-01 | 3.62e-02 | 6.42e-01 |
| PLASMA LIPOPROTEIN ASSEMBLY | 11 | 1.63e-01 | 2.64e-01 | 0.3790 | 8.11e-02 | 0.161000 | -0.149000 | 0.134000 | 0.266000 | 6.41e-01 | 3.57e-01 | 3.93e-01 | 4.41e-01 | 1.26e-01 |
| MTORC1 MEDIATED SIGNALLING | 24 | 1.59e-01 | 2.59e-01 | 0.3780 | 8.85e-02 | 0.148000 | -0.251000 | 0.188000 | -0.122000 | 4.53e-01 | 2.09e-01 | 3.33e-02 | 1.10e-01 | 3.01e-01 |
| CONDENSATION OF PROPHASE CHROMOSOMES | 26 | 4.35e-02 | 1.01e-01 | 0.3780 | -4.41e-03 | 0.097300 | -0.146000 | -0.323000 | -0.087700 | 9.69e-01 | 3.91e-01 | 1.98e-01 | 4.32e-03 | 4.39e-01 |
| MISMATCH REPAIR | 14 | 1.34e-01 | 2.30e-01 | 0.3780 | 2.62e-01 | -0.008190 | -0.162000 | 0.217000 | -0.028600 | 9.01e-02 | 9.58e-01 | 2.94e-01 | 1.60e-01 | 8.53e-01 |
| TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 | 15 | 2.45e-01 | 3.56e-01 | 0.3780 | 1.93e-01 | 0.066900 | -0.021800 | 0.296000 | -0.115000 | 1.97e-01 | 6.54e-01 | 8.84e-01 | 4.74e-02 | 4.42e-01 |
| DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE | 26 | 4.00e-02 | 9.48e-02 | 0.3770 | -1.19e-02 | 0.175000 | 0.153000 | 0.258000 | 0.147000 | 9.16e-01 | 1.22e-01 | 1.78e-01 | 2.27e-02 | 1.95e-01 |
| COLLAGEN DEGRADATION | 47 | 3.28e-04 | 1.88e-03 | 0.3750 | -1.65e-01 | -0.168000 | 0.228000 | -0.162000 | -0.082500 | 4.99e-02 | 4.64e-02 | 6.74e-03 | 5.50e-02 | 3.28e-01 |
| PCP CE PATHWAY | 89 | 1.54e-04 | 1.02e-03 | 0.3750 | 2.54e-01 | 0.198000 | -0.164000 | 0.002450 | -0.101000 | 3.53e-05 | 1.22e-03 | 7.64e-03 | 9.68e-01 | 1.01e-01 |
| EFFECTS OF PIP2 HYDROLYSIS | 27 | 1.28e-01 | 2.23e-01 | 0.3750 | -1.88e-01 | -0.097600 | 0.241000 | 0.146000 | 0.128000 | 9.06e-02 | 3.80e-01 | 3.05e-02 | 1.88e-01 | 2.50e-01 |
| RNA POLYMERASE III CHAIN ELONGATION | 18 | 2.25e-01 | 3.34e-01 | 0.3730 | 1.86e-02 | -0.072500 | -0.167000 | -0.308000 | -0.106000 | 8.91e-01 | 5.95e-01 | 2.20e-01 | 2.38e-02 | 4.38e-01 |
| SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX | 12 | 9.48e-02 | 1.79e-01 | 0.3720 | 2.46e-01 | 0.162000 | 0.201000 | -0.106000 | -0.023900 | 1.41e-01 | 3.33e-01 | 2.27e-01 | 5.25e-01 | 8.86e-01 |
| REGULATION OF IFNG SIGNALING | 13 | 4.33e-01 | 5.27e-01 | 0.3710 | 1.44e-01 | 0.143000 | -0.187000 | 0.245000 | -0.038100 | 3.67e-01 | 3.71e-01 | 2.44e-01 | 1.26e-01 | 8.12e-01 |
| TRANSCRIPTIONAL REGULATION BY RUNX2 | 107 | 3.27e-05 | 2.67e-04 | 0.3710 | 1.97e-01 | 0.190000 | -0.223000 | -0.060800 | -0.098900 | 4.47e-04 | 6.83e-04 | 6.97e-05 | 2.77e-01 | 7.73e-02 |
| TRAFFICKING OF AMPA RECEPTORS | 31 | 6.29e-02 | 1.32e-01 | 0.3710 | -2.49e-01 | -0.127000 | 0.146000 | 0.030300 | 0.194000 | 1.66e-02 | 2.21e-01 | 1.60e-01 | 7.70e-01 | 6.17e-02 |
| SHC MEDIATED CASCADE FGFR1 | 14 | 3.52e-01 | 4.56e-01 | 0.3710 | 1.65e-02 | 0.259000 | -0.139000 | -0.126000 | -0.187000 | 9.15e-01 | 9.28e-02 | 3.69e-01 | 4.13e-01 | 2.25e-01 |
| TRANSCRIPTIONAL REGULATION BY RUNX3 | 92 | 3.15e-05 | 2.61e-04 | 0.3710 | 2.51e-01 | 0.211000 | -0.170000 | -0.040600 | 0.003550 | 3.31e-05 | 4.76e-04 | 4.94e-03 | 5.01e-01 | 9.53e-01 |
| DEPOLYMERISATION OF THE NUCLEAR LAMINA | 12 | 4.10e-01 | 5.08e-01 | 0.3710 | 4.77e-02 | 0.007860 | 0.084000 | 0.343000 | 0.103000 | 7.75e-01 | 9.62e-01 | 6.14e-01 | 3.98e-02 | 5.35e-01 |
| GABA RECEPTOR ACTIVATION | 52 | 8.80e-06 | 8.10e-05 | 0.3710 | -1.02e-01 | 0.215000 | -0.182000 | 0.190000 | 0.107000 | 2.05e-01 | 7.21e-03 | 2.36e-02 | 1.76e-02 | 1.80e-01 |
| ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | 32 | 9.35e-02 | 1.78e-01 | 0.3710 | 4.42e-02 | -0.030700 | 0.253000 | 0.053000 | 0.260000 | 6.65e-01 | 7.63e-01 | 1.34e-02 | 6.04e-01 | 1.08e-02 |
| KERATAN SULFATE BIOSYNTHESIS | 23 | 7.80e-02 | 1.56e-01 | 0.3700 | 1.46e-01 | 0.239000 | 0.115000 | 0.172000 | 0.128000 | 2.26e-01 | 4.76e-02 | 3.40e-01 | 1.54e-01 | 2.88e-01 |
| G ALPHA 12 13 SIGNALLING EVENTS | 74 | 2.09e-04 | 1.31e-03 | 0.3700 | 4.57e-02 | 0.002150 | 0.260000 | 0.152000 | 0.210000 | 4.97e-01 | 9.75e-01 | 1.08e-04 | 2.35e-02 | 1.84e-03 |
| NEUREXINS AND NEUROLIGINS | 54 | 7.56e-03 | 2.50e-02 | 0.3700 | -4.13e-02 | -0.073100 | 0.295000 | 0.055800 | 0.199000 | 6.00e-01 | 3.53e-01 | 1.77e-04 | 4.78e-01 | 1.15e-02 |
| CYTOSOLIC SULFONATION OF SMALL MOLECULES | 15 | 4.30e-01 | 5.24e-01 | 0.3700 | 7.38e-02 | 0.182000 | -0.016100 | 0.296000 | -0.101000 | 6.21e-01 | 2.21e-01 | 9.14e-01 | 4.72e-02 | 4.99e-01 |
| GLUCAGON SIGNALING IN METABOLIC REGULATION | 29 | 3.50e-03 | 1.37e-02 | 0.3690 | 3.00e-02 | 0.284000 | -0.083900 | 0.051100 | 0.212000 | 7.80e-01 | 8.20e-03 | 4.34e-01 | 6.34e-01 | 4.83e-02 |
| TIGHT JUNCTION INTERACTIONS | 16 | 3.21e-01 | 4.26e-01 | 0.3690 | -7.45e-02 | 0.173000 | -0.040300 | 0.179000 | -0.259000 | 6.06e-01 | 2.30e-01 | 7.80e-01 | 2.16e-01 | 7.34e-02 |
| RHOC GTPASE CYCLE | 73 | 4.27e-04 | 2.35e-03 | 0.3680 | -8.39e-03 | -0.042200 | 0.212000 | 0.191000 | 0.228000 | 9.01e-01 | 5.34e-01 | 1.74e-03 | 4.72e-03 | 7.58e-04 |
| CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE | 49 | 7.64e-03 | 2.52e-02 | 0.3680 | 6.49e-02 | 0.153000 | -0.058200 | 0.312000 | -0.084300 | 4.32e-01 | 6.33e-02 | 4.81e-01 | 1.61e-04 | 3.07e-01 |
| NEUTROPHIL DEGRANULATION | 376 | 5.21e-19 | 2.88e-17 | 0.3680 | 1.78e-01 | 0.255000 | -0.165000 | 0.099100 | -0.039600 | 3.76e-09 | 2.15e-17 | 4.53e-08 | 1.00e-03 | 1.89e-01 |
| UCH PROTEINASES | 88 | 2.75e-04 | 1.63e-03 | 0.3670 | 2.10e-01 | 0.182000 | -0.199000 | -0.077700 | -0.108000 | 6.48e-04 | 3.19e-03 | 1.26e-03 | 2.08e-01 | 7.92e-02 |
| SUMOYLATION OF DNA METHYLATION PROTEINS | 16 | 2.82e-01 | 3.93e-01 | 0.3670 | -2.51e-01 | -0.095200 | 0.237000 | -0.069000 | 0.042600 | 8.24e-02 | 5.10e-01 | 1.01e-01 | 6.33e-01 | 7.68e-01 |
| CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 48 | 4.53e-03 | 1.68e-02 | 0.3670 | 1.36e-01 | 0.072200 | 0.140000 | 0.158000 | 0.258000 | 1.03e-01 | 3.87e-01 | 9.25e-02 | 5.90e-02 | 2.03e-03 |
| NUCLEAR ENVELOPE BREAKDOWN | 47 | 4.96e-03 | 1.81e-02 | 0.3650 | -2.49e-01 | -0.068000 | 0.152000 | 0.207000 | 0.034600 | 3.16e-03 | 4.20e-01 | 7.16e-02 | 1.43e-02 | 6.82e-01 |
| ACTIVATION OF THE PRE REPLICATIVE COMPLEX | 29 | 1.55e-01 | 2.55e-01 | 0.3650 | -6.83e-02 | 0.105000 | -0.149000 | 0.159000 | -0.264000 | 5.24e-01 | 3.28e-01 | 1.66e-01 | 1.37e-01 | 1.38e-02 |
| SIGNALING BY FGFR2 IIIA TM | 19 | 3.24e-01 | 4.28e-01 | 0.3650 | 1.43e-01 | 0.206000 | -0.153000 | -0.107000 | -0.188000 | 2.82e-01 | 1.21e-01 | 2.47e-01 | 4.21e-01 | 1.55e-01 |
| CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | 73 | 4.12e-04 | 2.28e-03 | 0.3650 | -1.10e-01 | -0.071900 | 0.285000 | 0.119000 | 0.143000 | 1.04e-01 | 2.88e-01 | 2.60e-05 | 7.94e-02 | 3.53e-02 |
| NEGATIVE REGULATION OF FGFR4 SIGNALING | 21 | 1.73e-01 | 2.74e-01 | 0.3640 | -3.76e-02 | 0.296000 | -0.045100 | 0.193000 | -0.066900 | 7.65e-01 | 1.90e-02 | 7.20e-01 | 1.25e-01 | 5.96e-01 |
| DEFECTS IN COBALAMIN B12 METABOLISM | 12 | 5.38e-01 | 6.22e-01 | 0.3640 | 1.91e-01 | 0.123000 | -0.080700 | 0.263000 | -0.074800 | 2.53e-01 | 4.62e-01 | 6.29e-01 | 1.14e-01 | 6.54e-01 |
| PLASMA LIPOPROTEIN REMODELING | 13 | 1.21e-01 | 2.15e-01 | 0.3640 | -2.62e-01 | 0.053500 | -0.055500 | 0.143000 | 0.193000 | 1.02e-01 | 7.38e-01 | 7.29e-01 | 3.74e-01 | 2.29e-01 |
| NF KB IS ACTIVATED AND SIGNALS SURVIVAL | 13 | 2.98e-01 | 4.08e-01 | 0.3640 | 2.31e-01 | 0.174000 | 0.048300 | -0.168000 | 0.135000 | 1.50e-01 | 2.77e-01 | 7.63e-01 | 2.94e-01 | 4.01e-01 |
| SARS COV 2 INFECTION | 65 | 1.77e-03 | 7.85e-03 | 0.3640 | 1.00e-01 | 0.284000 | -0.107000 | 0.173000 | -0.006300 | 1.63e-01 | 7.52e-05 | 1.35e-01 | 1.60e-02 | 9.30e-01 |
| AQUAPORIN MEDIATED TRANSPORT | 39 | 1.21e-03 | 5.88e-03 | 0.3630 | -4.12e-04 | 0.308000 | -0.136000 | 0.075900 | 0.114000 | 9.96e-01 | 8.75e-04 | 1.43e-01 | 4.12e-01 | 2.17e-01 |
| COLLAGEN FORMATION | 74 | 6.86e-06 | 6.47e-05 | 0.3630 | -4.17e-02 | -0.174000 | 0.289000 | -0.127000 | 0.010000 | 5.36e-01 | 9.77e-03 | 1.70e-05 | 5.89e-02 | 8.82e-01 |
| NEGATIVE REGULATION OF FGFR3 SIGNALING | 23 | 9.27e-02 | 1.77e-01 | 0.3630 | -3.41e-02 | 0.304000 | -0.008810 | 0.188000 | -0.053600 | 7.77e-01 | 1.16e-02 | 9.42e-01 | 1.19e-01 | 6.56e-01 |
| REGULATED NECROSIS | 45 | 3.22e-02 | 7.89e-02 | 0.3620 | 3.12e-02 | 0.193000 | -0.263000 | -0.098800 | -0.116000 | 7.17e-01 | 2.48e-02 | 2.26e-03 | 2.52e-01 | 1.77e-01 |
| PRC2 METHYLATES HISTONES AND DNA | 28 | 5.60e-02 | 1.22e-01 | 0.3610 | 2.25e-01 | 0.002890 | -0.077800 | -0.272000 | -0.006510 | 3.94e-02 | 9.79e-01 | 4.76e-01 | 1.28e-02 | 9.52e-01 |
| TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX | 14 | 3.62e-01 | 4.66e-01 | 0.3610 | 1.40e-01 | 0.293000 | 0.031200 | 0.156000 | -0.000676 | 3.66e-01 | 5.80e-02 | 8.40e-01 | 3.11e-01 | 9.97e-01 |
| RNA POLYMERASE I PROMOTER ESCAPE | 46 | 5.81e-03 | 2.04e-02 | 0.3610 | 2.21e-01 | 0.069600 | -0.140000 | -0.186000 | -0.148000 | 9.47e-03 | 4.14e-01 | 1.01e-01 | 2.89e-02 | 8.20e-02 |
| N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | 23 | 2.78e-02 | 7.03e-02 | 0.3600 | -8.91e-02 | 0.226000 | 0.113000 | 0.159000 | 0.180000 | 4.60e-01 | 6.06e-02 | 3.46e-01 | 1.87e-01 | 1.35e-01 |
| NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 | 11 | 5.56e-01 | 6.30e-01 | 0.3590 | 1.39e-01 | -0.061900 | 0.075700 | -0.050100 | 0.312000 | 4.24e-01 | 7.22e-01 | 6.64e-01 | 7.74e-01 | 7.28e-02 |
| BILE ACID AND BILE SALT METABOLISM | 24 | 1.20e-01 | 2.13e-01 | 0.3590 | 1.46e-01 | 0.207000 | 0.088500 | 0.238000 | 0.019300 | 2.17e-01 | 7.96e-02 | 4.53e-01 | 4.35e-02 | 8.70e-01 |
| SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS | 56 | 1.75e-03 | 7.80e-03 | 0.3590 | -3.15e-01 | -0.082300 | 0.136000 | 0.055200 | 0.037200 | 4.54e-05 | 2.87e-01 | 7.95e-02 | 4.75e-01 | 6.30e-01 |
| HSF1 ACTIVATION | 25 | 3.24e-01 | 4.28e-01 | 0.3590 | 7.25e-02 | 0.181000 | -0.255000 | -0.072000 | -0.144000 | 5.31e-01 | 1.16e-01 | 2.76e-02 | 5.33e-01 | 2.13e-01 |
| DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | 26 | 7.59e-02 | 1.53e-01 | 0.3580 | -7.17e-02 | 0.282000 | -0.199000 | -0.027400 | -0.054700 | 5.27e-01 | 1.28e-02 | 7.90e-02 | 8.09e-01 | 6.29e-01 |
| RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN | 37 | 2.29e-02 | 6.06e-02 | 0.3580 | -1.11e-01 | -0.051700 | 0.171000 | -0.183000 | 0.224000 | 2.43e-01 | 5.86e-01 | 7.12e-02 | 5.46e-02 | 1.83e-02 |
| MITOTIC METAPHASE AND ANAPHASE | 203 | 4.07e-08 | 6.11e-07 | 0.3570 | 6.71e-02 | 0.170000 | -0.210000 | 0.128000 | -0.184000 | 9.99e-02 | 3.17e-05 | 2.62e-07 | 1.68e-03 | 6.40e-06 |
| SIGNALING BY CSF3 G CSF | 29 | 1.68e-01 | 2.69e-01 | 0.3570 | 2.00e-01 | 0.234000 | -0.176000 | -0.023400 | -0.021100 | 6.20e-02 | 2.90e-02 | 1.00e-01 | 8.28e-01 | 8.44e-01 |
| SIGNALING BY BMP | 24 | 3.64e-02 | 8.73e-02 | 0.3560 | -1.28e-02 | 0.251000 | -0.073200 | 0.183000 | 0.158000 | 9.14e-01 | 3.35e-02 | 5.35e-01 | 1.20e-01 | 1.80e-01 |
| INTERLEUKIN RECEPTOR SHC SIGNALING | 20 | 1.62e-01 | 2.62e-01 | 0.3550 | -6.01e-02 | 0.078500 | 0.205000 | 0.115000 | 0.247000 | 6.42e-01 | 5.43e-01 | 1.12e-01 | 3.72e-01 | 5.59e-02 |
| RHOBTB1 GTPASE CYCLE | 23 | 2.73e-01 | 3.82e-01 | 0.3550 | 9.50e-02 | 0.116000 | -0.208000 | 0.180000 | -0.167000 | 4.30e-01 | 3.34e-01 | 8.42e-02 | 1.36e-01 | 1.65e-01 |
| GPVI MEDIATED ACTIVATION CASCADE | 31 | 7.04e-02 | 1.46e-01 | 0.3550 | 9.21e-02 | 0.292000 | -0.021400 | 0.174000 | -0.035800 | 3.75e-01 | 4.87e-03 | 8.37e-01 | 9.35e-02 | 7.30e-01 |
| KERATAN SULFATE KERATIN METABOLISM | 29 | 6.49e-02 | 1.36e-01 | 0.3550 | 1.77e-01 | 0.212000 | 0.086600 | 0.164000 | 0.123000 | 9.97e-02 | 4.83e-02 | 4.20e-01 | 1.26e-01 | 2.53e-01 |
| SIGNALING BY HIPPO | 20 | 2.02e-01 | 3.06e-01 | 0.3540 | -9.67e-02 | 0.180000 | -0.053800 | 0.284000 | 0.003730 | 4.54e-01 | 1.64e-01 | 6.77e-01 | 2.78e-02 | 9.77e-01 |
| DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 | 22 | 1.47e-01 | 2.45e-01 | 0.3530 | 3.05e-02 | 0.296000 | -0.113000 | -0.059200 | -0.141000 | 8.05e-01 | 1.63e-02 | 3.57e-01 | 6.31e-01 | 2.51e-01 |
| SARS COV 1 INFECTION | 48 | 4.68e-02 | 1.08e-01 | 0.3530 | 8.84e-02 | 0.258000 | -0.134000 | 0.163000 | -0.073700 | 2.89e-01 | 1.97e-03 | 1.09e-01 | 5.06e-02 | 3.77e-01 |
| SIGNALING BY WNT IN CANCER | 30 | 1.67e-02 | 4.77e-02 | 0.3520 | -1.02e-01 | 0.198000 | 0.139000 | 0.235000 | 0.007120 | 3.34e-01 | 6.09e-02 | 1.88e-01 | 2.58e-02 | 9.46e-01 |
| RND3 GTPASE CYCLE | 37 | 4.48e-02 | 1.03e-01 | 0.3520 | -5.41e-02 | -0.148000 | 0.151000 | 0.139000 | 0.239000 | 5.69e-01 | 1.19e-01 | 1.11e-01 | 1.43e-01 | 1.20e-02 |
| GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER | 24 | 2.95e-01 | 4.05e-01 | 0.3520 | 1.60e-01 | 0.183000 | -0.221000 | -0.101000 | -0.078400 | 1.75e-01 | 1.21e-01 | 6.15e-02 | 3.90e-01 | 5.06e-01 |
| PEPTIDE HORMONE METABOLISM | 57 | 2.79e-04 | 1.64e-03 | 0.3520 | 4.81e-02 | 0.167000 | -0.268000 | 0.149000 | 0.000517 | 5.31e-01 | 2.91e-02 | 4.74e-04 | 5.21e-02 | 9.95e-01 |
| FCGR3A MEDIATED IL10 SYNTHESIS | 32 | 6.45e-03 | 2.21e-02 | 0.3520 | -1.06e-01 | 0.194000 | 0.082800 | 0.178000 | 0.192000 | 3.01e-01 | 5.77e-02 | 4.18e-01 | 8.12e-02 | 6.08e-02 |
| ERK MAPK TARGETS | 22 | 8.04e-02 | 1.59e-01 | 0.3520 | -1.77e-01 | 0.092400 | 0.120000 | 0.220000 | -0.145000 | 1.50e-01 | 4.53e-01 | 3.28e-01 | 7.42e-02 | 2.38e-01 |
| ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION | 26 | 5.93e-02 | 1.27e-01 | 0.3520 | 1.71e-01 | 0.237000 | -0.052900 | 0.038900 | 0.185000 | 1.31e-01 | 3.65e-02 | 6.41e-01 | 7.31e-01 | 1.03e-01 |
| THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION | 13 | 2.16e-01 | 3.22e-01 | 0.3520 | 3.01e-01 | 0.067100 | 0.123000 | 0.075400 | -0.089000 | 6.06e-02 | 6.76e-01 | 4.41e-01 | 6.38e-01 | 5.78e-01 |
| PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION | 21 | 4.97e-01 | 5.87e-01 | 0.3510 | 8.53e-02 | 0.222000 | -0.197000 | -0.014400 | -0.166000 | 4.99e-01 | 7.79e-02 | 1.18e-01 | 9.09e-01 | 1.89e-01 |
| HIV TRANSCRIPTION INITIATION | 45 | 2.83e-02 | 7.07e-02 | 0.3500 | 8.34e-02 | 0.091000 | -0.169000 | -0.018800 | -0.280000 | 3.33e-01 | 2.91e-01 | 4.94e-02 | 8.27e-01 | 1.16e-03 |
| ACYL CHAIN REMODELLING OF PE | 16 | 4.27e-01 | 5.23e-01 | 0.3490 | 1.99e-01 | 0.148000 | -0.015500 | 0.236000 | -0.068700 | 1.69e-01 | 3.06e-01 | 9.14e-01 | 1.02e-01 | 6.34e-01 |
| N GLYCAN ANTENNAE ELONGATION | 15 | 1.40e-01 | 2.37e-01 | 0.3490 | 3.56e-02 | 0.216000 | 0.077200 | -0.031900 | 0.259000 | 8.12e-01 | 1.48e-01 | 6.05e-01 | 8.30e-01 | 8.26e-02 |
| ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K | 11 | 1.99e-01 | 3.02e-01 | 0.3480 | -1.29e-01 | 0.295000 | 0.106000 | 0.077800 | 0.026700 | 4.60e-01 | 9.08e-02 | 5.44e-01 | 6.55e-01 | 8.78e-01 |
| FRS MEDIATED FGFR1 SIGNALING | 16 | 3.80e-01 | 4.80e-01 | 0.3470 | 4.02e-02 | 0.291000 | -0.106000 | -0.015700 | -0.150000 | 7.81e-01 | 4.36e-02 | 4.64e-01 | 9.14e-01 | 3.00e-01 |
| POLYMERASE SWITCHING | 14 | 6.29e-01 | 6.96e-01 | 0.3450 | 2.32e-01 | 0.154000 | -0.178000 | 0.065100 | -0.077600 | 1.33e-01 | 3.19e-01 | 2.49e-01 | 6.73e-01 | 6.15e-01 |
| REDUCTION OF CYTOSOLIC CA LEVELS | 11 | 5.77e-01 | 6.50e-01 | 0.3450 | -3.37e-01 | -0.055800 | 0.006980 | 0.013400 | -0.044500 | 5.26e-02 | 7.48e-01 | 9.68e-01 | 9.39e-01 | 7.98e-01 |
| DISEASES OF CARBOHYDRATE METABOLISM | 28 | 9.33e-02 | 1.77e-01 | 0.3450 | 1.71e-01 | 0.269000 | -0.069600 | 0.055800 | 0.095900 | 1.17e-01 | 1.36e-02 | 5.24e-01 | 6.09e-01 | 3.80e-01 |
| SUMOYLATION OF DNA REPLICATION PROTEINS | 42 | 1.36e-02 | 4.01e-02 | 0.3440 | -2.56e-01 | -0.017600 | 0.087200 | 0.211000 | -0.026200 | 4.14e-03 | 8.43e-01 | 3.28e-01 | 1.80e-02 | 7.69e-01 |
| MISCELLANEOUS TRANSPORT AND BINDING EVENTS | 20 | 1.14e-01 | 2.06e-01 | 0.3430 | -3.68e-02 | 0.221000 | 0.128000 | 0.226000 | -0.022500 | 7.76e-01 | 8.77e-02 | 3.20e-01 | 8.07e-02 | 8.62e-01 |
| RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 104 | 1.73e-05 | 1.54e-04 | 0.3430 | 1.49e-01 | 0.268000 | -0.094900 | 0.111000 | 0.044800 | 8.58e-03 | 2.36e-06 | 9.47e-02 | 4.99e-02 | 4.31e-01 |
| HEDGEHOG ON STATE | 82 | 1.48e-03 | 6.82e-03 | 0.3430 | 2.44e-01 | 0.189000 | -0.115000 | 0.079200 | -0.053300 | 1.37e-04 | 3.16e-03 | 7.10e-02 | 2.16e-01 | 4.04e-01 |
| CELL CYCLE CHECKPOINTS | 237 | 8.01e-09 | 1.44e-07 | 0.3430 | 2.67e-02 | 0.127000 | -0.230000 | 0.041700 | -0.214000 | 4.80e-01 | 7.50e-04 | 1.08e-09 | 2.70e-01 | 1.52e-08 |
| ECM PROTEOGLYCANS | 63 | 5.68e-03 | 2.01e-02 | 0.3420 | 1.05e-01 | -0.079400 | 0.228000 | -0.108000 | 0.191000 | 1.52e-01 | 2.76e-01 | 1.79e-03 | 1.38e-01 | 8.75e-03 |
| SIGNALING BY NOTCH3 | 48 | 2.37e-02 | 6.21e-02 | 0.3420 | -2.92e-02 | -0.052600 | 0.177000 | 0.051000 | 0.282000 | 7.26e-01 | 5.28e-01 | 3.40e-02 | 5.41e-01 | 7.16e-04 |
| TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 | 12 | 6.48e-01 | 7.08e-01 | 0.3420 | 2.38e-01 | 0.165000 | -0.035200 | 0.172000 | -0.047700 | 1.54e-01 | 3.22e-01 | 8.33e-01 | 3.01e-01 | 7.75e-01 |
| NUCLEOBASE CATABOLISM | 31 | 1.31e-01 | 2.27e-01 | 0.3420 | 2.62e-01 | 0.150000 | -0.109000 | 0.118000 | 0.002510 | 1.15e-02 | 1.49e-01 | 2.95e-01 | 2.57e-01 | 9.81e-01 |
| CGMP EFFECTS | 15 | 4.79e-01 | 5.70e-01 | 0.3410 | -2.21e-01 | -0.186000 | -0.006610 | -0.172000 | 0.059000 | 1.39e-01 | 2.13e-01 | 9.65e-01 | 2.48e-01 | 6.92e-01 |
| INTERLEUKIN 1 FAMILY SIGNALING | 119 | 5.08e-05 | 3.83e-04 | 0.3400 | 1.85e-01 | 0.235000 | -0.107000 | 0.061400 | -0.104000 | 4.90e-04 | 9.81e-06 | 4.43e-02 | 2.48e-01 | 4.92e-02 |
| GABA B RECEPTOR ACTIVATION | 39 | 1.80e-03 | 7.94e-03 | 0.3400 | -2.88e-02 | 0.215000 | -0.065500 | 0.175000 | 0.182000 | 7.56e-01 | 2.01e-02 | 4.79e-01 | 5.82e-02 | 4.89e-02 |
| FREE FATTY ACIDS REGULATE INSULIN SECRETION | 10 | 3.52e-01 | 4.56e-01 | 0.3390 | -1.98e-03 | 0.101000 | -0.032500 | 0.148000 | 0.286000 | 9.91e-01 | 5.80e-01 | 8.59e-01 | 4.18e-01 | 1.17e-01 |
| G0 AND EARLY G1 | 24 | 7.93e-02 | 1.57e-01 | 0.3390 | 1.30e-01 | 0.010500 | -0.055100 | 0.244000 | -0.187000 | 2.69e-01 | 9.29e-01 | 6.40e-01 | 3.84e-02 | 1.13e-01 |
| KINESINS | 47 | 5.13e-02 | 1.15e-01 | 0.3380 | -5.39e-02 | -0.256000 | 0.168000 | 0.023800 | 0.131000 | 5.23e-01 | 2.36e-03 | 4.70e-02 | 7.78e-01 | 1.20e-01 |
| MUCOPOLYSACCHARIDOSES | 11 | 5.50e-01 | 6.27e-01 | 0.3380 | 1.01e-01 | 0.172000 | 0.116000 | 0.127000 | 0.212000 | 5.64e-01 | 3.23e-01 | 5.06e-01 | 4.65e-01 | 2.24e-01 |
| ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS | 35 | 5.22e-02 | 1.16e-01 | 0.3380 | -7.03e-02 | -0.112000 | 0.257000 | 0.170000 | 0.037000 | 4.72e-01 | 2.53e-01 | 8.51e-03 | 8.10e-02 | 7.05e-01 |
| UPTAKE AND FUNCTION OF ANTHRAX TOXINS | 11 | 5.46e-01 | 6.25e-01 | 0.3370 | 5.91e-02 | 0.190000 | 0.137000 | 0.199000 | 0.126000 | 7.35e-01 | 2.76e-01 | 4.31e-01 | 2.54e-01 | 4.69e-01 |
| BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA | 16 | 2.73e-01 | 3.82e-01 | 0.3370 | -1.28e-01 | -0.001420 | -0.030100 | -0.246000 | -0.189000 | 3.74e-01 | 9.92e-01 | 8.35e-01 | 8.86e-02 | 1.90e-01 |
| TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN | 11 | 3.77e-01 | 4.79e-01 | 0.3370 | -1.14e-01 | 0.175000 | 0.167000 | 0.201000 | -0.041700 | 5.14e-01 | 3.16e-01 | 3.36e-01 | 2.49e-01 | 8.11e-01 |
| WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 | 13 | 5.02e-01 | 5.91e-01 | 0.3370 | 5.10e-02 | 0.251000 | 0.029500 | 0.210000 | 0.052600 | 7.50e-01 | 1.18e-01 | 8.54e-01 | 1.89e-01 | 7.43e-01 |
| BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS | 30 | 5.92e-02 | 1.27e-01 | 0.3360 | 3.76e-02 | 0.010500 | -0.136000 | -0.303000 | 0.039500 | 7.22e-01 | 9.21e-01 | 1.97e-01 | 4.14e-03 | 7.08e-01 |
| RHO GTPASES ACTIVATE PKNS | 46 | 1.87e-02 | 5.19e-02 | 0.3360 | 6.83e-02 | 0.206000 | -0.179000 | -0.169000 | -0.073100 | 4.23e-01 | 1.59e-02 | 3.59e-02 | 4.75e-02 | 3.91e-01 |
| HDACS DEACETYLATE HISTONES | 44 | 7.10e-02 | 1.46e-01 | 0.3360 | -2.72e-02 | -0.154000 | 0.096600 | -0.219000 | 0.176000 | 7.55e-01 | 7.66e-02 | 2.68e-01 | 1.22e-02 | 4.32e-02 |
| SIGNALING BY INSULIN RECEPTOR | 60 | 8.41e-03 | 2.75e-02 | 0.3360 | -6.56e-02 | 0.244000 | -0.102000 | 0.114000 | -0.159000 | 3.80e-01 | 1.08e-03 | 1.73e-01 | 1.26e-01 | 3.28e-02 |
| TRAF6 MEDIATED IRF7 ACTIVATION | 15 | 6.31e-01 | 6.97e-01 | 0.3360 | 4.33e-02 | -0.057000 | 0.245000 | 0.070200 | 0.206000 | 7.71e-01 | 7.02e-01 | 1.00e-01 | 6.38e-01 | 1.67e-01 |
| SYNTHESIS OF PA | 29 | 1.15e-01 | 2.06e-01 | 0.3350 | 7.21e-02 | 0.105000 | 0.141000 | 0.245000 | 0.129000 | 5.02e-01 | 3.30e-01 | 1.90e-01 | 2.24e-02 | 2.31e-01 |
| TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | 32 | 2.85e-02 | 7.12e-02 | 0.3350 | -2.47e-02 | 0.277000 | -0.171000 | -0.074400 | -0.001450 | 8.09e-01 | 6.69e-03 | 9.33e-02 | 4.67e-01 | 9.89e-01 |
| SIGNALING BY NOTCH2 | 33 | 1.94e-01 | 2.97e-01 | 0.3350 | 5.49e-02 | -0.068000 | 0.187000 | 0.017800 | 0.264000 | 5.86e-01 | 4.99e-01 | 6.37e-02 | 8.60e-01 | 8.78e-03 |
| PARASITE INFECTION | 54 | 2.64e-03 | 1.11e-02 | 0.3350 | 7.57e-03 | 0.217000 | 0.068800 | 0.245000 | -0.016700 | 9.23e-01 | 5.92e-03 | 3.82e-01 | 1.84e-03 | 8.32e-01 |
| FCERI MEDIATED MAPK ACTIVATION | 28 | 1.60e-01 | 2.61e-01 | 0.3350 | -1.41e-01 | 0.207000 | -0.117000 | 0.159000 | -0.101000 | 1.95e-01 | 5.76e-02 | 2.85e-01 | 1.46e-01 | 3.57e-01 |
| FORMATION OF THE CORNIFIED ENVELOPE | 22 | 1.22e-01 | 2.16e-01 | 0.3350 | -6.74e-02 | -0.034900 | 0.228000 | -0.201000 | 0.118000 | 5.84e-01 | 7.77e-01 | 6.39e-02 | 1.03e-01 | 3.39e-01 |
| KERATINIZATION | 22 | 1.22e-01 | 2.16e-01 | 0.3350 | -6.74e-02 | -0.034900 | 0.228000 | -0.201000 | 0.118000 | 5.84e-01 | 7.77e-01 | 6.39e-02 | 1.03e-01 | 3.39e-01 |
| CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND | 12 | 6.48e-01 | 7.07e-01 | 0.3350 | 2.19e-01 | 0.134000 | -0.183000 | -0.112000 | 0.003500 | 1.89e-01 | 4.21e-01 | 2.73e-01 | 5.02e-01 | 9.83e-01 |
| TNF SIGNALING | 43 | 3.14e-02 | 7.74e-02 | 0.3340 | 1.47e-01 | 0.071800 | 0.145000 | 0.139000 | 0.212000 | 9.61e-02 | 4.16e-01 | 1.01e-01 | 1.15e-01 | 1.62e-02 |
| RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK | 48 | 1.03e-02 | 3.22e-02 | 0.3340 | -1.54e-01 | 0.070900 | -0.006500 | 0.279000 | -0.072100 | 6.47e-02 | 3.96e-01 | 9.38e-01 | 8.33e-04 | 3.88e-01 |
| DEFECTS IN VITAMIN AND COFACTOR METABOLISM | 20 | 3.08e-01 | 4.15e-01 | 0.3340 | 1.91e-01 | 0.108000 | -0.008180 | 0.249000 | 0.039100 | 1.39e-01 | 4.03e-01 | 9.50e-01 | 5.41e-02 | 7.62e-01 |
| SMOOTH MUSCLE CONTRACTION | 33 | 9.44e-02 | 1.79e-01 | 0.3340 | 8.76e-02 | 0.206000 | -0.205000 | -0.135000 | -0.032700 | 3.84e-01 | 4.09e-02 | 4.14e-02 | 1.79e-01 | 7.46e-01 |
| TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS | 42 | 5.16e-03 | 1.86e-02 | 0.3330 | 1.72e-01 | 0.140000 | 0.044400 | -0.176000 | 0.169000 | 5.38e-02 | 1.17e-01 | 6.19e-01 | 4.84e-02 | 5.80e-02 |
| LAGGING STRAND SYNTHESIS | 20 | 5.55e-01 | 6.29e-01 | 0.3330 | 1.45e-01 | 0.175000 | -0.192000 | 0.106000 | -0.105000 | 2.63e-01 | 1.76e-01 | 1.37e-01 | 4.13e-01 | 4.15e-01 |
| COSTIMULATION BY THE CD28 FAMILY | 47 | 5.26e-02 | 1.17e-01 | 0.3320 | -6.19e-05 | 0.206000 | -0.072300 | 0.227000 | -0.104000 | 9.99e-01 | 1.44e-02 | 3.91e-01 | 7.20e-03 | 2.16e-01 |
| PECAM1 INTERACTIONS | 12 | 6.03e-01 | 6.72e-01 | 0.3310 | 1.34e-01 | 0.143000 | 0.068100 | 0.193000 | 0.170000 | 4.21e-01 | 3.91e-01 | 6.83e-01 | 2.48e-01 | 3.07e-01 |
| FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES | 23 | 8.93e-02 | 1.72e-01 | 0.3300 | 1.62e-01 | 0.158000 | -0.128000 | -0.072400 | 0.190000 | 1.78e-01 | 1.90e-01 | 2.87e-01 | 5.48e-01 | 1.14e-01 |
| GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS | 12 | 3.75e-01 | 4.79e-01 | 0.3300 | 3.35e-02 | 0.202000 | 0.128000 | 0.060100 | 0.217000 | 8.41e-01 | 2.25e-01 | 4.44e-01 | 7.18e-01 | 1.94e-01 |
| G PROTEIN BETA GAMMA SIGNALLING | 30 | 1.68e-01 | 2.69e-01 | 0.3290 | 1.48e-01 | 0.246000 | -0.161000 | 0.002070 | 0.018100 | 1.62e-01 | 1.99e-02 | 1.26e-01 | 9.84e-01 | 8.64e-01 |
| HYALURONAN METABOLISM | 15 | 4.75e-01 | 5.66e-01 | 0.3290 | 1.51e-01 | 0.004640 | 0.088300 | 0.123000 | 0.250000 | 3.11e-01 | 9.75e-01 | 5.54e-01 | 4.09e-01 | 9.37e-02 |
| PRE NOTCH EXPRESSION AND PROCESSING | 62 | 1.43e-02 | 4.16e-02 | 0.3290 | -3.13e-02 | -0.078800 | 0.241000 | -0.075000 | 0.193000 | 6.71e-01 | 2.84e-01 | 1.04e-03 | 3.07e-01 | 8.54e-03 |
| ACYL CHAIN REMODELLING OF PC | 16 | 3.87e-01 | 4.86e-01 | 0.3290 | 3.05e-01 | 0.050300 | 0.014000 | 0.109000 | 0.022300 | 3.48e-02 | 7.27e-01 | 9.23e-01 | 4.49e-01 | 8.77e-01 |
| OTHER SEMAPHORIN INTERACTIONS | 19 | 5.53e-01 | 6.29e-01 | 0.3290 | -1.36e-01 | -0.130000 | 0.163000 | -0.083300 | 0.197000 | 3.03e-01 | 3.26e-01 | 2.18e-01 | 5.30e-01 | 1.37e-01 |
| TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA | 16 | 3.89e-01 | 4.87e-01 | 0.3290 | -9.32e-02 | -0.031700 | -0.077200 | -0.201000 | -0.228000 | 5.19e-01 | 8.26e-01 | 5.93e-01 | 1.64e-01 | 1.15e-01 |
| INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL | 15 | 6.34e-01 | 7.00e-01 | 0.3280 | -3.06e-03 | 0.256000 | -0.116000 | 0.145000 | -0.089200 | 9.84e-01 | 8.64e-02 | 4.38e-01 | 3.32e-01 | 5.50e-01 |
| REGULATION OF BETA CELL DEVELOPMENT | 23 | 3.16e-01 | 4.22e-01 | 0.3280 | -1.84e-01 | -0.080700 | 0.223000 | -0.018000 | 0.131000 | 1.28e-01 | 5.03e-01 | 6.38e-02 | 8.82e-01 | 2.77e-01 |
| ACTIVATION OF BH3 ONLY PROTEINS | 28 | 8.39e-02 | 1.64e-01 | 0.3270 | -3.09e-01 | -0.015000 | -0.081700 | 0.046200 | -0.050300 | 4.66e-03 | 8.91e-01 | 4.54e-01 | 6.73e-01 | 6.45e-01 |
| METABOLISM OF PORPHYRINS | 19 | 2.25e-01 | 3.34e-01 | 0.3270 | 2.19e-03 | 0.221000 | 0.026100 | 0.160000 | -0.179000 | 9.87e-01 | 9.59e-02 | 8.44e-01 | 2.27e-01 | 1.78e-01 |
| G2 M DNA DAMAGE CHECKPOINT | 64 | 9.71e-03 | 3.06e-02 | 0.3270 | -3.71e-02 | 0.013000 | -0.207000 | -0.076700 | -0.238000 | 6.08e-01 | 8.57e-01 | 4.23e-03 | 2.89e-01 | 9.85e-04 |
| O LINKED GLYCOSYLATION | 80 | 2.42e-03 | 1.02e-02 | 0.3270 | -9.98e-02 | -0.105000 | 0.251000 | 0.104000 | 0.108000 | 1.23e-01 | 1.04e-01 | 1.05e-04 | 1.07e-01 | 9.39e-02 |
| INHIBITION OF DNA RECOMBINATION AT TELOMERE | 34 | 7.11e-02 | 1.46e-01 | 0.3260 | 1.19e-01 | 0.047400 | -0.124000 | -0.248000 | -0.114000 | 2.29e-01 | 6.33e-01 | 2.11e-01 | 1.22e-02 | 2.48e-01 |
| MITOCHONDRIAL TRNA AMINOACYLATION | 21 | 1.83e-01 | 2.85e-01 | 0.3260 | 1.82e-01 | -0.049200 | 0.093500 | 0.240000 | 0.068900 | 1.49e-01 | 6.96e-01 | 4.58e-01 | 5.70e-02 | 5.85e-01 |
| MITOTIC TELOPHASE CYTOKINESIS | 13 | 7.02e-01 | 7.56e-01 | 0.3260 | -4.10e-02 | 0.116000 | -0.101000 | 0.208000 | -0.194000 | 7.98e-01 | 4.68e-01 | 5.28e-01 | 1.94e-01 | 2.25e-01 |
| ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | 37 | 8.31e-02 | 1.63e-01 | 0.3260 | 1.99e-01 | 0.115000 | -0.084500 | 0.200000 | -0.077200 | 3.59e-02 | 2.27e-01 | 3.74e-01 | 3.55e-02 | 4.16e-01 |
| HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR | 48 | 1.29e-01 | 2.24e-01 | 0.3250 | -4.98e-02 | 0.142000 | -0.197000 | 0.046100 | -0.206000 | 5.51e-01 | 8.82e-02 | 1.84e-02 | 5.81e-01 | 1.36e-02 |
| HEME BIOSYNTHESIS | 13 | 3.21e-01 | 4.26e-01 | 0.3250 | 5.58e-02 | 0.168000 | 0.114000 | 0.193000 | -0.154000 | 7.28e-01 | 2.93e-01 | 4.76e-01 | 2.28e-01 | 3.37e-01 |
| NEGATIVE REGULATION OF FGFR2 SIGNALING | 26 | 1.85e-01 | 2.87e-01 | 0.3250 | -4.55e-02 | 0.230000 | -0.058800 | 0.090100 | -0.197000 | 6.88e-01 | 4.22e-02 | 6.04e-01 | 4.27e-01 | 8.24e-02 |
| CHROMATIN MODIFYING ENZYMES | 216 | 6.44e-07 | 7.63e-06 | 0.3250 | -9.54e-02 | -0.161000 | 0.210000 | -0.062900 | 0.149000 | 1.59e-02 | 4.69e-05 | 1.05e-07 | 1.12e-01 | 1.65e-04 |
| NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | 20 | 3.18e-01 | 4.23e-01 | 0.3240 | -1.99e-01 | -0.125000 | 0.030000 | -0.168000 | 0.144000 | 1.23e-01 | 3.33e-01 | 8.16e-01 | 1.93e-01 | 2.66e-01 |
| RHOH GTPASE CYCLE | 37 | 1.37e-01 | 2.35e-01 | 0.3240 | 2.00e-01 | 0.193000 | -0.159000 | 0.049100 | 0.002530 | 3.52e-02 | 4.23e-02 | 9.39e-02 | 6.05e-01 | 9.79e-01 |
| EXTRA NUCLEAR ESTROGEN SIGNALING | 65 | 1.75e-02 | 4.94e-02 | 0.3240 | 7.20e-02 | 0.251000 | -0.139000 | 0.124000 | -0.045700 | 3.16e-01 | 4.66e-04 | 5.25e-02 | 8.44e-02 | 5.24e-01 |
| NEGATIVE REGULATION OF MET ACTIVITY | 20 | 3.94e-01 | 4.91e-01 | 0.3240 | 4.34e-02 | 0.192000 | -0.002740 | 0.257000 | -0.007960 | 7.37e-01 | 1.38e-01 | 9.83e-01 | 4.63e-02 | 9.51e-01 |
| SIGNALING BY FGFR4 | 31 | 8.62e-02 | 1.67e-01 | 0.3230 | 1.57e-02 | 0.296000 | -0.064400 | 0.111000 | -0.010300 | 8.79e-01 | 4.36e-03 | 5.35e-01 | 2.84e-01 | 9.21e-01 |
| THE PHOTOTRANSDUCTION CASCADE | 19 | 1.59e-01 | 2.59e-01 | 0.3230 | -1.34e-01 | 0.082700 | -0.178000 | -0.216000 | 0.032000 | 3.11e-01 | 5.33e-01 | 1.79e-01 | 1.03e-01 | 8.09e-01 |
| ACTIVATION OF AMPK DOWNSTREAM OF NMDARS | 20 | 5.11e-02 | 1.14e-01 | 0.3230 | -4.22e-02 | -0.069200 | 0.088300 | 0.052300 | -0.295000 | 7.44e-01 | 5.92e-01 | 4.94e-01 | 6.85e-01 | 2.24e-02 |
| MRNA SPLICING MINOR PATHWAY | 52 | 4.87e-02 | 1.10e-01 | 0.3220 | 1.59e-01 | 0.198000 | -0.147000 | -0.066400 | -0.116000 | 4.75e-02 | 1.34e-02 | 6.71e-02 | 4.08e-01 | 1.50e-01 |
| DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX | 41 | 7.50e-03 | 2.49e-02 | 0.3220 | 1.32e-01 | 0.176000 | 0.018600 | -0.033200 | 0.232000 | 1.43e-01 | 5.12e-02 | 8.37e-01 | 7.13e-01 | 1.01e-02 |
| PI 3K CASCADE FGFR1 | 14 | 4.32e-01 | 5.27e-01 | 0.3220 | -1.09e-01 | 0.255000 | -0.057200 | 0.047700 | -0.145000 | 4.80e-01 | 9.81e-02 | 7.11e-01 | 7.57e-01 | 3.47e-01 |
| SIGNALING BY EGFR IN CANCER | 21 | 1.56e-01 | 2.56e-01 | 0.3220 | 1.88e-02 | 0.233000 | -0.152000 | -0.159000 | 0.023400 | 8.82e-01 | 6.48e-02 | 2.28e-01 | 2.07e-01 | 8.53e-01 |
| LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS | 19 | 3.05e-01 | 4.15e-01 | 0.3210 | -3.67e-02 | 0.191000 | -0.084400 | 0.237000 | 0.043400 | 7.82e-01 | 1.49e-01 | 5.24e-01 | 7.34e-02 | 7.44e-01 |
| REGULATION OF IFNA SIGNALING | 12 | 6.12e-01 | 6.80e-01 | 0.3210 | 6.05e-02 | -0.132000 | 0.091500 | 0.055800 | 0.266000 | 7.17e-01 | 4.29e-01 | 5.83e-01 | 7.38e-01 | 1.11e-01 |
| G1 S SPECIFIC TRANSCRIPTION | 26 | 4.95e-02 | 1.12e-01 | 0.3210 | 1.73e-01 | 0.016400 | 0.024600 | 0.195000 | -0.185000 | 1.26e-01 | 8.85e-01 | 8.28e-01 | 8.58e-02 | 1.03e-01 |
| AURKA ACTIVATION BY TPX2 | 71 | 1.97e-03 | 8.56e-03 | 0.3200 | -2.42e-01 | -0.168000 | 0.030300 | -0.042000 | -0.115000 | 4.29e-04 | 1.43e-02 | 6.59e-01 | 5.41e-01 | 9.39e-02 |
| RHOF GTPASE CYCLE | 40 | 2.83e-02 | 7.07e-02 | 0.3200 | -5.03e-02 | 0.052100 | 0.020000 | 0.309000 | 0.033400 | 5.82e-01 | 5.69e-01 | 8.27e-01 | 7.13e-04 | 7.15e-01 |
| ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS | 22 | 1.65e-01 | 2.67e-01 | 0.3200 | -1.95e-02 | 0.121000 | 0.206000 | 0.136000 | 0.163000 | 8.74e-01 | 3.28e-01 | 9.52e-02 | 2.69e-01 | 1.85e-01 |
| B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION | 46 | 1.16e-02 | 3.52e-02 | 0.3200 | 1.82e-01 | 0.056000 | -0.069200 | -0.234000 | -0.080100 | 3.24e-02 | 5.11e-01 | 4.17e-01 | 6.16e-03 | 3.47e-01 |
| TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX | 11 | 6.01e-01 | 6.69e-01 | 0.3190 | 5.16e-02 | 0.278000 | -0.024400 | 0.068100 | -0.131000 | 7.67e-01 | 1.11e-01 | 8.89e-01 | 6.96e-01 | 4.53e-01 |
| PLASMA LIPOPROTEIN CLEARANCE | 26 | 1.86e-01 | 2.88e-01 | 0.3180 | 1.05e-01 | 0.194000 | -0.019000 | 0.196000 | 0.118000 | 3.54e-01 | 8.72e-02 | 8.67e-01 | 8.38e-02 | 2.97e-01 |
| P75 NTR RECEPTOR MEDIATED SIGNALLING | 94 | 2.23e-04 | 1.36e-03 | 0.3180 | -1.16e-01 | -0.057100 | 0.245000 | 0.127000 | 0.091800 | 5.24e-02 | 3.39e-01 | 4.10e-05 | 3.40e-02 | 1.24e-01 |
| REGULATION OF KIT SIGNALING | 16 | 3.71e-01 | 4.75e-01 | 0.3180 | -1.60e-01 | -0.068200 | 0.077500 | 0.185000 | 0.175000 | 2.69e-01 | 6.37e-01 | 5.92e-01 | 2.00e-01 | 2.26e-01 |
| RHOA GTPASE CYCLE | 141 | 1.14e-06 | 1.29e-05 | 0.3170 | -3.62e-02 | 0.012300 | 0.184000 | 0.174000 | 0.188000 | 4.59e-01 | 8.02e-01 | 1.65e-04 | 3.72e-04 | 1.21e-04 |
| CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING | 28 | 8.53e-02 | 1.66e-01 | 0.3170 | -1.42e-01 | 0.114000 | 0.141000 | 0.216000 | 0.030800 | 1.94e-01 | 2.95e-01 | 1.96e-01 | 4.84e-02 | 7.78e-01 |
| RNA POLYMERASE I TRANSCRIPTION TERMINATION | 31 | 3.84e-02 | 9.16e-02 | 0.3170 | 2.45e-01 | -0.045800 | -0.084200 | -0.107000 | -0.141000 | 1.83e-02 | 6.59e-01 | 4.17e-01 | 3.01e-01 | 1.75e-01 |
| RESOLUTION OF SISTER CHROMATID COHESION | 99 | 5.82e-04 | 3.14e-03 | 0.3170 | -8.26e-02 | 0.103000 | -0.130000 | 0.199000 | -0.162000 | 1.56e-01 | 7.59e-02 | 2.52e-02 | 6.12e-04 | 5.38e-03 |
| CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION | 21 | 4.01e-01 | 4.98e-01 | 0.3160 | -4.58e-02 | 0.152000 | -0.072200 | 0.107000 | -0.241000 | 7.16e-01 | 2.27e-01 | 5.67e-01 | 3.98e-01 | 5.63e-02 |
| SIGNALING BY NOTCH1 | 75 | 1.16e-02 | 3.52e-02 | 0.3160 | -1.00e-02 | -0.058600 | 0.209000 | 0.035000 | 0.226000 | 8.81e-01 | 3.80e-01 | 1.78e-03 | 6.00e-01 | 7.09e-04 |
| SIGNALING BY ERBB2 ECD MUTANTS | 16 | 3.55e-01 | 4.59e-01 | 0.3150 | 3.36e-02 | 0.230000 | -0.153000 | -0.147000 | 0.014900 | 8.16e-01 | 1.11e-01 | 2.89e-01 | 3.08e-01 | 9.18e-01 |
| PERK REGULATES GENE EXPRESSION | 28 | 1.74e-01 | 2.75e-01 | 0.3150 | -2.54e-02 | 0.202000 | -0.101000 | -0.043600 | -0.214000 | 8.16e-01 | 6.41e-02 | 3.57e-01 | 6.90e-01 | 5.00e-02 |
| COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC | 44 | 6.06e-02 | 1.29e-01 | 0.3150 | -5.17e-02 | 0.090500 | -0.067800 | 0.243000 | -0.158000 | 5.53e-01 | 2.99e-01 | 4.37e-01 | 5.35e-03 | 7.03e-02 |
| REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | 86 | 1.29e-04 | 8.72e-04 | 0.3150 | 1.45e-01 | 0.177000 | -0.038000 | 0.156000 | 0.145000 | 2.04e-02 | 4.64e-03 | 5.43e-01 | 1.22e-02 | 2.00e-02 |
| FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX | 45 | 4.81e-02 | 1.09e-01 | 0.3140 | 7.32e-02 | -0.058000 | 0.118000 | -0.219000 | 0.168000 | 3.96e-01 | 5.01e-01 | 1.71e-01 | 1.11e-02 | 5.13e-02 |
| DISEASES OF DNA REPAIR | 11 | 4.83e-01 | 5.74e-01 | 0.3140 | -1.60e-01 | -0.157000 | -0.014900 | 0.219000 | -0.018400 | 3.59e-01 | 3.68e-01 | 9.32e-01 | 2.09e-01 | 9.16e-01 |
| GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION | 38 | 2.13e-02 | 5.72e-02 | 0.3140 | 1.18e-01 | 0.204000 | -0.074400 | 0.086200 | 0.173000 | 2.09e-01 | 2.94e-02 | 4.28e-01 | 3.58e-01 | 6.58e-02 |
| RHOBTB GTPASE CYCLE | 35 | 3.03e-01 | 4.14e-01 | 0.3130 | 1.14e-01 | 0.176000 | -0.183000 | 0.108000 | -0.096100 | 2.45e-01 | 7.20e-02 | 6.15e-02 | 2.67e-01 | 3.25e-01 |
| ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | 33 | 1.26e-01 | 2.20e-01 | 0.3130 | 8.48e-03 | -0.011700 | -0.214000 | 0.004910 | -0.228000 | 9.33e-01 | 9.07e-01 | 3.31e-02 | 9.61e-01 | 2.35e-02 |
| INWARDLY RECTIFYING K CHANNELS | 31 | 4.80e-02 | 1.09e-01 | 0.3130 | -7.80e-02 | 0.235000 | -0.175000 | 0.071800 | 0.031900 | 4.52e-01 | 2.35e-02 | 9.22e-02 | 4.89e-01 | 7.58e-01 |
| HIV INFECTION | 219 | 3.96e-06 | 4.03e-05 | 0.3130 | 4.53e-02 | 0.173000 | -0.176000 | 0.075400 | -0.171000 | 2.49e-01 | 1.03e-05 | 7.23e-06 | 5.49e-02 | 1.32e-05 |
| INTEGRATION OF ENERGY METABOLISM | 98 | 1.10e-05 | 1.01e-04 | 0.3130 | -1.92e-02 | 0.106000 | 0.119000 | 0.175000 | 0.204000 | 7.42e-01 | 7.09e-02 | 4.11e-02 | 2.82e-03 | 4.90e-04 |
| GAP JUNCTION ASSEMBLY | 21 | 6.59e-01 | 7.16e-01 | 0.3130 | 8.74e-02 | 0.186000 | -0.184000 | 0.012100 | -0.147000 | 4.88e-01 | 1.40e-01 | 1.45e-01 | 9.24e-01 | 2.44e-01 |
| NEGATIVE REGULATION OF THE PI3K AKT NETWORK | 88 | 1.22e-04 | 8.37e-04 | 0.3130 | -1.01e-01 | 0.152000 | 0.044100 | 0.240000 | -0.069900 | 1.00e-01 | 1.38e-02 | 4.75e-01 | 1.01e-04 | 2.57e-01 |
| SYNTHESIS OF PC | 24 | 3.07e-01 | 4.15e-01 | 0.3120 | 1.75e-01 | 0.157000 | 0.042100 | 0.200000 | 0.016400 | 1.39e-01 | 1.84e-01 | 7.21e-01 | 8.94e-02 | 8.89e-01 |
| PHOSPHOLIPID METABOLISM | 183 | 2.16e-09 | 4.64e-08 | 0.3110 | -3.66e-02 | 0.033200 | 0.188000 | 0.228000 | 0.082700 | 3.94e-01 | 4.39e-01 | 1.17e-05 | 1.13e-07 | 5.42e-02 |
| PYRIMIDINE CATABOLISM | 10 | 6.07e-01 | 6.75e-01 | 0.3100 | 1.70e-01 | -0.047300 | -0.105000 | -0.099600 | -0.211000 | 3.53e-01 | 7.96e-01 | 5.64e-01 | 5.85e-01 | 2.49e-01 |
| THE NLRP3 INFLAMMASOME | 14 | 7.71e-01 | 8.14e-01 | 0.3100 | -6.10e-03 | 0.205000 | -0.178000 | -0.020400 | -0.149000 | 9.68e-01 | 1.84e-01 | 2.49e-01 | 8.95e-01 | 3.34e-01 |
| MITOTIC SPINDLE CHECKPOINT | 95 | 1.30e-03 | 6.25e-03 | 0.3100 | -6.61e-02 | 0.090400 | -0.173000 | 0.163000 | -0.165000 | 2.66e-01 | 1.28e-01 | 3.59e-03 | 6.19e-03 | 5.54e-03 |
| RAC1 GTPASE CYCLE | 176 | 1.25e-08 | 2.07e-07 | 0.3100 | -4.97e-02 | 0.017200 | 0.226000 | 0.150000 | 0.141000 | 2.56e-01 | 6.94e-01 | 2.48e-07 | 6.10e-04 | 1.31e-03 |
| IRS MEDIATED SIGNALLING | 36 | 4.28e-02 | 1.00e-01 | 0.3100 | -1.48e-01 | 0.200000 | -0.019400 | 0.097900 | -0.156000 | 1.26e-01 | 3.78e-02 | 8.40e-01 | 3.10e-01 | 1.06e-01 |
| LATE ENDOSOMAL MICROAUTOPHAGY | 30 | 2.07e-01 | 3.12e-01 | 0.3100 | 1.21e-01 | 0.136000 | -0.238000 | 0.062000 | -0.048200 | 2.50e-01 | 1.99e-01 | 2.41e-02 | 5.57e-01 | 6.48e-01 |
| NEUROTRANSMITTER RELEASE CYCLE | 46 | 2.83e-03 | 1.18e-02 | 0.3090 | -1.68e-01 | 0.062100 | 0.038300 | 0.170000 | 0.183000 | 4.81e-02 | 4.66e-01 | 6.53e-01 | 4.67e-02 | 3.22e-02 |
| GLYCOSAMINOGLYCAN METABOLISM | 112 | 2.45e-05 | 2.11e-04 | 0.3090 | 1.06e-01 | 0.108000 | 0.112000 | 0.181000 | 0.166000 | 5.24e-02 | 4.89e-02 | 4.07e-02 | 9.45e-04 | 2.50e-03 |
| TRAF6 MEDIATED NF KB ACTIVATION | 22 | 3.05e-01 | 4.15e-01 | 0.3080 | 1.83e-01 | 0.062700 | 0.143000 | -0.055200 | 0.185000 | 1.37e-01 | 6.11e-01 | 2.45e-01 | 6.54e-01 | 1.34e-01 |
| IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX | 10 | 5.17e-01 | 6.04e-01 | 0.3080 | 1.62e-02 | 0.304000 | 0.005600 | 0.016600 | -0.037600 | 9.29e-01 | 9.57e-02 | 9.76e-01 | 9.28e-01 | 8.37e-01 |
| PURINE SALVAGE | 12 | 8.47e-01 | 8.76e-01 | 0.3070 | 7.23e-02 | 0.191000 | -0.135000 | 0.161000 | -0.094300 | 6.64e-01 | 2.53e-01 | 4.18e-01 | 3.36e-01 | 5.72e-01 |
| RHO GTPASES ACTIVATE NADPH OXIDASES | 18 | 4.13e-01 | 5.11e-01 | 0.3070 | 4.57e-02 | 0.082500 | 0.009250 | 0.250000 | -0.151000 | 7.37e-01 | 5.45e-01 | 9.46e-01 | 6.65e-02 | 2.68e-01 |
| GLUCOSE METABOLISM | 80 | 6.42e-05 | 4.68e-04 | 0.3060 | -2.37e-01 | 0.099300 | 0.076100 | 0.145000 | -0.034000 | 2.55e-04 | 1.25e-01 | 2.40e-01 | 2.49e-02 | 5.99e-01 |
| DOWNSTREAM SIGNAL TRANSDUCTION | 29 | 5.51e-02 | 1.20e-01 | 0.3060 | -1.13e-01 | 0.133000 | 0.077000 | 0.158000 | 0.180000 | 2.93e-01 | 2.15e-01 | 4.73e-01 | 1.41e-01 | 9.27e-02 |
| ADHERENS JUNCTIONS INTERACTIONS | 29 | 8.04e-03 | 2.65e-02 | 0.3060 | -2.26e-01 | -0.031500 | -0.115000 | 0.101000 | 0.135000 | 3.48e-02 | 7.69e-01 | 2.85e-01 | 3.47e-01 | 2.10e-01 |
| GAB1 SIGNALOSOME | 13 | 4.16e-01 | 5.13e-01 | 0.3060 | -1.17e-01 | 0.114000 | 0.157000 | 0.064900 | 0.194000 | 4.64e-01 | 4.75e-01 | 3.26e-01 | 6.85e-01 | 2.26e-01 |
| UPTAKE AND ACTIONS OF BACTERIAL TOXINS | 28 | 2.83e-02 | 7.07e-02 | 0.3060 | -2.05e-01 | 0.175000 | -0.031000 | 0.096600 | 0.103000 | 6.07e-02 | 1.09e-01 | 7.77e-01 | 3.76e-01 | 3.47e-01 |
| GLYCOLYSIS | 66 | 1.18e-03 | 5.76e-03 | 0.3050 | -2.75e-01 | 0.031500 | 0.072600 | 0.104000 | -0.021800 | 1.11e-04 | 6.58e-01 | 3.08e-01 | 1.46e-01 | 7.60e-01 |
| INTERLEUKIN 2 FAMILY SIGNALING | 32 | 5.52e-02 | 1.20e-01 | 0.3050 | -1.28e-01 | 0.075200 | 0.141000 | 0.094300 | 0.205000 | 2.09e-01 | 4.62e-01 | 1.66e-01 | 3.56e-01 | 4.52e-02 |
| CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER | 26 | 1.16e-01 | 2.07e-01 | 0.3050 | -6.22e-04 | 0.010100 | 0.278000 | 0.104000 | 0.069500 | 9.96e-01 | 9.29e-01 | 1.43e-02 | 3.57e-01 | 5.40e-01 |
| NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS | 26 | 4.03e-01 | 4.99e-01 | 0.3040 | 5.48e-02 | -0.044300 | 0.221000 | 0.084000 | 0.178000 | 6.29e-01 | 6.96e-01 | 5.11e-02 | 4.59e-01 | 1.16e-01 |
| PROCESSING OF CAPPED INTRONLESS PRE MRNA | 28 | 1.98e-01 | 3.01e-01 | 0.3040 | -1.36e-01 | -0.059500 | -0.065700 | -0.173000 | -0.190000 | 2.14e-01 | 5.86e-01 | 5.47e-01 | 1.12e-01 | 8.17e-02 |
| TRNA PROCESSING IN THE NUCLEUS | 56 | 7.07e-03 | 2.37e-02 | 0.3030 | -1.97e-01 | -0.067200 | 0.051300 | 0.144000 | -0.159000 | 1.06e-02 | 3.85e-01 | 5.07e-01 | 6.30e-02 | 4.01e-02 |
| RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | 78 | 1.55e-03 | 7.03e-03 | 0.3030 | -2.18e-01 | -0.160000 | 0.031800 | -0.026400 | -0.130000 | 8.83e-04 | 1.45e-02 | 6.28e-01 | 6.87e-01 | 4.74e-02 |
| DEGRADATION OF THE EXTRACELLULAR MATRIX | 102 | 6.28e-05 | 4.64e-04 | 0.3030 | -1.32e-01 | -0.148000 | 0.214000 | -0.081800 | -0.011700 | 2.18e-02 | 9.93e-03 | 1.93e-04 | 1.54e-01 | 8.38e-01 |
| PROGRAMMED CELL DEATH | 182 | 4.12e-05 | 3.27e-04 | 0.3020 | 5.91e-02 | 0.174000 | -0.210000 | 0.006560 | -0.117000 | 1.70e-01 | 5.52e-05 | 1.05e-06 | 8.79e-01 | 6.58e-03 |
| TRANSCRIPTIONAL REGULATION BY MECP2 | 58 | 1.24e-01 | 2.18e-01 | 0.3020 | -8.65e-02 | -0.141000 | 0.176000 | -0.047000 | 0.175000 | 2.55e-01 | 6.29e-02 | 2.05e-02 | 5.36e-01 | 2.09e-02 |
| RHO GTPASES ACTIVATE ROCKS | 19 | 5.40e-01 | 6.22e-01 | 0.3020 | 1.30e-01 | 0.166000 | -0.155000 | -0.137000 | -0.064300 | 3.26e-01 | 2.11e-01 | 2.41e-01 | 3.03e-01 | 6.28e-01 |
| COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM | 13 | 6.47e-01 | 7.07e-01 | 0.3020 | 1.17e-01 | 0.075700 | -0.017000 | 0.262000 | -0.053900 | 4.66e-01 | 6.36e-01 | 9.15e-01 | 1.02e-01 | 7.36e-01 |
| MEIOTIC RECOMBINATION | 36 | 1.12e-01 | 2.04e-01 | 0.3020 | 2.15e-02 | 0.012100 | -0.220000 | -0.187000 | -0.084300 | 8.23e-01 | 9.00e-01 | 2.25e-02 | 5.22e-02 | 3.81e-01 |
| SUMOYLATION OF IMMUNE RESPONSE PROTEINS | 11 | 6.37e-01 | 7.01e-01 | 0.3010 | 2.34e-01 | 0.126000 | 0.073700 | -0.087900 | 0.082000 | 1.79e-01 | 4.69e-01 | 6.72e-01 | 6.14e-01 | 6.38e-01 |
| PLATELET AGGREGATION PLUG FORMATION | 31 | 4.76e-02 | 1.09e-01 | 0.3010 | -3.45e-02 | 0.125000 | 0.211000 | 0.099400 | 0.139000 | 7.40e-01 | 2.29e-01 | 4.23e-02 | 3.38e-01 | 1.80e-01 |
| FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS | 81 | 1.61e-04 | 1.05e-03 | 0.3000 | -3.32e-02 | 0.198000 | 0.082400 | 0.207000 | -0.000963 | 6.06e-01 | 2.07e-03 | 2.00e-01 | 1.31e-03 | 9.88e-01 |
| CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS | 19 | 2.86e-01 | 3.96e-01 | 0.2990 | 3.63e-02 | 0.193000 | -0.147000 | -0.167000 | 0.041800 | 7.84e-01 | 1.46e-01 | 2.68e-01 | 2.07e-01 | 7.53e-01 |
| PLATELET CALCIUM HOMEOSTASIS | 25 | 3.62e-01 | 4.67e-01 | 0.2990 | -1.71e-01 | -0.112000 | 0.136000 | 0.154000 | 0.075000 | 1.40e-01 | 3.32e-01 | 2.40e-01 | 1.82e-01 | 5.16e-01 |
| CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 89 | 8.90e-05 | 6.33e-04 | 0.2990 | 9.73e-02 | 0.242000 | -0.068900 | 0.066000 | 0.111000 | 1.13e-01 | 7.85e-05 | 2.61e-01 | 2.82e-01 | 7.16e-02 |
| SPRY REGULATION OF FGF SIGNALING | 16 | 5.73e-01 | 6.46e-01 | 0.2990 | 7.91e-03 | 0.189000 | 0.017500 | 0.230000 | 0.003790 | 9.56e-01 | 1.91e-01 | 9.04e-01 | 1.11e-01 | 9.79e-01 |
| PYRIMIDINE SALVAGE | 10 | 4.58e-01 | 5.50e-01 | 0.2980 | 5.38e-02 | -0.251000 | 0.007930 | 0.102000 | 0.114000 | 7.68e-01 | 1.70e-01 | 9.65e-01 | 5.78e-01 | 5.33e-01 |
| OPIOID SIGNALLING | 86 | 8.05e-05 | 5.80e-04 | 0.2970 | -6.03e-02 | 0.194000 | -0.012000 | 0.200000 | 0.082900 | 3.34e-01 | 1.84e-03 | 8.48e-01 | 1.38e-03 | 1.84e-01 |
| SIGNALING BY FGFR3 | 34 | 9.57e-02 | 1.80e-01 | 0.2970 | 2.96e-02 | 0.272000 | -0.028100 | 0.113000 | 0.000175 | 7.65e-01 | 6.14e-03 | 7.77e-01 | 2.56e-01 | 9.99e-01 |
| ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS | 83 | 6.16e-04 | 3.29e-03 | 0.2970 | -1.38e-01 | -0.051300 | 0.151000 | 0.206000 | -0.032900 | 3.02e-02 | 4.19e-01 | 1.73e-02 | 1.18e-03 | 6.05e-01 |
| APOPTOSIS | 160 | 2.75e-04 | 1.63e-03 | 0.2960 | 8.55e-02 | 0.170000 | -0.200000 | -0.001100 | -0.107000 | 6.24e-02 | 2.17e-04 | 1.30e-05 | 9.81e-01 | 1.98e-02 |
| PROLACTIN RECEPTOR SIGNALING | 11 | 6.38e-01 | 7.01e-01 | 0.2960 | 1.48e-01 | 0.186000 | 0.122000 | 0.113000 | 0.056500 | 3.94e-01 | 2.87e-01 | 4.82e-01 | 5.17e-01 | 7.46e-01 |
| GLYCEROPHOSPHOLIPID BIOSYNTHESIS | 105 | 2.11e-04 | 1.31e-03 | 0.2950 | 8.02e-02 | 0.060800 | 0.134000 | 0.214000 | 0.116000 | 1.56e-01 | 2.82e-01 | 1.76e-02 | 1.55e-04 | 4.06e-02 |
| FGFR2 ALTERNATIVE SPLICING | 25 | 1.50e-01 | 2.48e-01 | 0.2950 | 2.37e-01 | -0.066400 | -0.083400 | -0.114000 | -0.080600 | 4.03e-02 | 5.65e-01 | 4.71e-01 | 3.24e-01 | 4.86e-01 |
| INITIATION OF NUCLEAR ENVELOPE NE REFORMATION | 16 | 6.61e-01 | 7.18e-01 | 0.2940 | 3.71e-02 | 0.226000 | -0.074800 | 0.168000 | -0.012500 | 7.97e-01 | 1.18e-01 | 6.05e-01 | 2.44e-01 | 9.31e-01 |
| REGULATION OF TP53 EXPRESSION AND DEGRADATION | 34 | 1.68e-01 | 2.69e-01 | 0.2920 | -3.24e-02 | 0.157000 | 0.022700 | 0.240000 | -0.041300 | 7.44e-01 | 1.14e-01 | 8.19e-01 | 1.55e-02 | 6.77e-01 |
| PROCESSING OF DNA DOUBLE STRAND BREAK ENDS | 69 | 1.71e-02 | 4.83e-02 | 0.2920 | 7.86e-03 | 0.006080 | -0.182000 | -0.068300 | -0.218000 | 9.10e-01 | 9.30e-01 | 9.02e-03 | 3.27e-01 | 1.78e-03 |
| EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION | 26 | 2.37e-01 | 3.47e-01 | 0.2920 | 1.14e-01 | 0.187000 | 0.027700 | 0.123000 | 0.147000 | 3.14e-01 | 9.96e-02 | 8.07e-01 | 2.80e-01 | 1.95e-01 |
| SLC TRANSPORTER DISORDERS | 67 | 3.70e-03 | 1.44e-02 | 0.2920 | -1.54e-01 | 0.037800 | 0.079600 | 0.222000 | 0.067200 | 2.94e-02 | 5.93e-01 | 2.60e-01 | 1.70e-03 | 3.42e-01 |
| DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS | 17 | 3.87e-01 | 4.86e-01 | 0.2920 | -8.00e-02 | 0.031700 | 0.074400 | 0.203000 | -0.176000 | 5.68e-01 | 8.21e-01 | 5.95e-01 | 1.46e-01 | 2.10e-01 |
| RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | 28 | 1.91e-01 | 2.94e-01 | 0.2920 | -1.43e-02 | -0.141000 | -0.125000 | -0.213000 | -0.063300 | 8.95e-01 | 1.97e-01 | 2.53e-01 | 5.12e-02 | 5.62e-01 |
| CARDIAC CONDUCTION | 102 | 1.11e-04 | 7.73e-04 | 0.2920 | -2.25e-01 | -0.036000 | 0.163000 | -0.000742 | 0.079500 | 8.67e-05 | 5.31e-01 | 4.37e-03 | 9.90e-01 | 1.66e-01 |
| PLATELET ACTIVATION SIGNALING AND AGGREGATION | 219 | 1.57e-09 | 3.64e-08 | 0.2910 | 8.36e-02 | 0.231000 | -0.027300 | 0.146000 | 0.047300 | 3.34e-02 | 3.80e-09 | 4.87e-01 | 1.93e-04 | 2.28e-01 |
| RIPK1 MEDIATED REGULATED NECROSIS | 25 | 3.77e-01 | 4.79e-01 | 0.2910 | -9.20e-03 | 0.128000 | -0.230000 | -0.102000 | -0.069900 | 9.37e-01 | 2.69e-01 | 4.63e-02 | 3.76e-01 | 5.45e-01 |
| HDR THROUGH SINGLE STRAND ANNEALING SSA | 36 | 2.05e-01 | 3.09e-01 | 0.2900 | -1.29e-01 | -0.022600 | -0.144000 | -0.067400 | -0.204000 | 1.80e-01 | 8.14e-01 | 1.34e-01 | 4.84e-01 | 3.40e-02 |
| CELLULAR RESPONSES TO EXTERNAL STIMULI | 594 | 4.91e-18 | 2.28e-16 | 0.2900 | 1.52e-01 | 0.153000 | -0.169000 | -0.041600 | -0.084000 | 2.90e-10 | 2.12e-10 | 2.57e-12 | 8.52e-02 | 5.03e-04 |
| SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER | 59 | 1.10e-01 | 2.01e-01 | 0.2900 | 1.50e-02 | -0.087400 | 0.173000 | 0.014200 | 0.214000 | 8.42e-01 | 2.46e-01 | 2.15e-02 | 8.51e-01 | 4.47e-03 |
| DAP12 INTERACTIONS | 29 | 1.43e-01 | 2.41e-01 | 0.2890 | 1.27e-01 | 0.222000 | -0.072700 | -0.091100 | 0.067900 | 2.36e-01 | 3.89e-02 | 4.98e-01 | 3.96e-01 | 5.27e-01 |
| DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | 13 | 3.07e-01 | 4.15e-01 | 0.2880 | -8.10e-02 | 0.208000 | 0.131000 | 0.031600 | 0.122000 | 6.13e-01 | 1.93e-01 | 4.12e-01 | 8.44e-01 | 4.47e-01 |
| RHOG GTPASE CYCLE | 73 | 5.10e-03 | 1.85e-02 | 0.2880 | 2.70e-02 | 0.147000 | 0.064900 | 0.235000 | 0.027700 | 6.90e-01 | 2.97e-02 | 3.38e-01 | 5.16e-04 | 6.83e-01 |
| NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | 19 | 6.32e-01 | 6.97e-01 | 0.2870 | 2.04e-02 | 0.164000 | -0.086800 | 0.212000 | -0.048600 | 8.78e-01 | 2.16e-01 | 5.12e-01 | 1.09e-01 | 7.14e-01 |
| CLASS B 2 SECRETIN FAMILY RECEPTORS | 62 | 1.42e-03 | 6.64e-03 | 0.2870 | 9.13e-02 | 0.147000 | -0.073900 | 0.132000 | 0.172000 | 2.14e-01 | 4.61e-02 | 3.14e-01 | 7.26e-02 | 1.93e-02 |
| RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | 85 | 1.34e-03 | 6.35e-03 | 0.2860 | -1.93e-01 | -0.161000 | 0.058900 | -0.009650 | -0.124000 | 2.14e-03 | 1.02e-02 | 3.49e-01 | 8.78e-01 | 4.91e-02 |
| ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION | 31 | 1.66e-01 | 2.68e-01 | 0.2860 | 1.51e-01 | 0.044400 | 0.004050 | -0.206000 | 0.120000 | 1.46e-01 | 6.69e-01 | 9.69e-01 | 4.75e-02 | 2.46e-01 |
| GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | 30 | 1.02e-01 | 1.90e-01 | 0.2850 | 1.33e-01 | -0.002320 | 0.067400 | 0.231000 | -0.073800 | 2.06e-01 | 9.82e-01 | 5.23e-01 | 2.84e-02 | 4.84e-01 |
| NUCLEAR ENVELOPE NE REASSEMBLY | 63 | 2.09e-02 | 5.63e-02 | 0.2850 | -6.84e-02 | 0.076000 | -0.020700 | 0.240000 | -0.113000 | 3.48e-01 | 2.97e-01 | 7.77e-01 | 1.01e-03 | 1.22e-01 |
| INNATE IMMUNE SYSTEM | 759 | 2.11e-22 | 1.29e-20 | 0.2840 | 1.14e-01 | 0.214000 | -0.114000 | 0.082700 | -0.046400 | 9.95e-08 | 1.70e-23 | 1.21e-07 | 1.18e-04 | 3.08e-02 |
| REGULATION OF SIGNALING BY CBL | 22 | 3.78e-01 | 4.79e-01 | 0.2840 | 2.64e-02 | 0.191000 | -0.068000 | 0.186000 | 0.067500 | 8.30e-01 | 1.22e-01 | 5.81e-01 | 1.32e-01 | 5.84e-01 |
| REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION | 10 | 7.75e-01 | 8.17e-01 | 0.2840 | 1.83e-01 | 0.092100 | -0.020100 | -0.172000 | 0.092700 | 3.16e-01 | 6.14e-01 | 9.12e-01 | 3.45e-01 | 6.12e-01 |
| CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | 31 | 1.49e-01 | 2.48e-01 | 0.2840 | 2.28e-01 | 0.161000 | 0.020100 | 0.013100 | -0.046700 | 2.79e-02 | 1.22e-01 | 8.47e-01 | 9.00e-01 | 6.53e-01 |
| DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | 23 | 7.08e-02 | 1.46e-01 | 0.2840 | -2.01e-01 | 0.193000 | 0.000170 | -0.039100 | 0.040200 | 9.57e-02 | 1.10e-01 | 9.99e-01 | 7.46e-01 | 7.39e-01 |
| RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR | 20 | 3.77e-01 | 4.79e-01 | 0.2840 | -1.45e-01 | 0.045600 | 0.179000 | 0.119000 | 0.106000 | 2.63e-01 | 7.24e-01 | 1.66e-01 | 3.56e-01 | 4.12e-01 |
| HS GAG DEGRADATION | 20 | 5.99e-01 | 6.69e-01 | 0.2830 | 1.03e-01 | -0.092100 | 0.096900 | -0.037500 | 0.224000 | 4.26e-01 | 4.76e-01 | 4.53e-01 | 7.71e-01 | 8.26e-02 |
| ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING | 20 | 4.99e-01 | 5.88e-01 | 0.2830 | -1.10e-01 | 0.136000 | -0.033200 | 0.215000 | -0.044300 | 3.95e-01 | 2.91e-01 | 7.97e-01 | 9.63e-02 | 7.32e-01 |
| BETA CATENIN INDEPENDENT WNT SIGNALING | 137 | 1.49e-04 | 9.93e-04 | 0.2820 | 2.03e-01 | 0.150000 | -0.123000 | -0.025000 | 0.011100 | 4.07e-05 | 2.45e-03 | 1.28e-02 | 6.14e-01 | 8.23e-01 |
| PROTEIN FOLDING | 88 | 2.18e-02 | 5.83e-02 | 0.2820 | 1.66e-01 | 0.145000 | -0.161000 | 0.021500 | -0.069400 | 7.28e-03 | 1.85e-02 | 9.10e-03 | 7.28e-01 | 2.61e-01 |
| INTERLEUKIN 10 SIGNALING | 17 | 2.73e-01 | 3.82e-01 | 0.2820 | 6.12e-03 | 0.169000 | -0.128000 | -0.134000 | 0.129000 | 9.65e-01 | 2.29e-01 | 3.62e-01 | 3.39e-01 | 3.56e-01 |
| SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | 20 | 5.57e-01 | 6.30e-01 | 0.2820 | 1.56e-01 | -0.032600 | 0.113000 | -0.130000 | 0.156000 | 2.26e-01 | 8.01e-01 | 3.82e-01 | 3.16e-01 | 2.27e-01 |
| TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 60 | 3.65e-03 | 1.42e-02 | 0.2820 | 7.26e-02 | 0.184000 | -0.041700 | 0.108000 | 0.164000 | 3.31e-01 | 1.38e-02 | 5.76e-01 | 1.49e-01 | 2.81e-02 |
| REGULATED PROTEOLYSIS OF P75NTR | 12 | 3.75e-01 | 4.79e-01 | 0.2810 | 7.36e-02 | 0.198000 | 0.178000 | 0.037100 | 0.038100 | 6.59e-01 | 2.35e-01 | 2.85e-01 | 8.24e-01 | 8.19e-01 |
| VEGFR2 MEDIATED CELL PROLIFERATION | 19 | 3.97e-01 | 4.94e-01 | 0.2810 | -9.35e-02 | 0.066200 | 0.040900 | 0.167000 | -0.191000 | 4.80e-01 | 6.18e-01 | 7.58e-01 | 2.08e-01 | 1.50e-01 |
| NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS | 23 | 4.61e-01 | 5.53e-01 | 0.2810 | 1.35e-01 | 0.031400 | 0.164000 | 0.014800 | 0.180000 | 2.62e-01 | 7.95e-01 | 1.73e-01 | 9.02e-01 | 1.34e-01 |
| RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | 24 | 5.74e-01 | 6.46e-01 | 0.2810 | -2.78e-02 | 0.167000 | -0.165000 | -0.056200 | -0.141000 | 8.14e-01 | 1.57e-01 | 1.61e-01 | 6.34e-01 | 2.32e-01 |
| SEMA3A PAK DEPENDENT AXON REPULSION | 16 | 5.58e-01 | 6.31e-01 | 0.2810 | -2.23e-01 | 0.054400 | 0.035000 | 0.126000 | -0.095700 | 1.22e-01 | 7.06e-01 | 8.08e-01 | 3.84e-01 | 5.08e-01 |
| G ALPHA Z SIGNALLING EVENTS | 43 | 3.93e-02 | 9.35e-02 | 0.2810 | 6.69e-02 | 0.178000 | -0.075300 | 0.147000 | 0.125000 | 4.48e-01 | 4.37e-02 | 3.93e-01 | 9.66e-02 | 1.57e-01 |
| NEURONAL SYSTEM | 359 | 6.65e-17 | 2.97e-15 | 0.2810 | -1.98e-01 | -0.010200 | 0.103000 | 0.121000 | 0.118000 | 1.23e-10 | 7.42e-01 | 8.26e-04 | 8.57e-05 | 1.21e-04 |
| PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE | 47 | 9.87e-03 | 3.10e-02 | 0.2800 | -4.17e-02 | 0.130000 | -0.025200 | 0.187000 | 0.155000 | 6.21e-01 | 1.23e-01 | 7.65e-01 | 2.67e-02 | 6.59e-02 |
| INTERLEUKIN 17 SIGNALING | 66 | 6.82e-03 | 2.29e-02 | 0.2800 | -1.65e-01 | 0.026000 | 0.090200 | 0.190000 | -0.076200 | 2.03e-02 | 7.16e-01 | 2.05e-01 | 7.50e-03 | 2.85e-01 |
| POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 57 | 2.06e-02 | 5.58e-02 | 0.2790 | -2.23e-01 | -0.106000 | -0.014100 | 0.101000 | -0.081900 | 3.64e-03 | 1.66e-01 | 8.54e-01 | 1.87e-01 | 2.85e-01 |
| DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 | 24 | 2.37e-01 | 3.47e-01 | 0.2790 | -3.32e-02 | 0.255000 | -0.108000 | -0.016400 | -0.006540 | 7.78e-01 | 3.07e-02 | 3.61e-01 | 8.90e-01 | 9.56e-01 |
| VIRAL MESSENGER RNA SYNTHESIS | 42 | 1.06e-01 | 1.94e-01 | 0.2790 | -2.33e-01 | -0.076900 | 0.117000 | 0.044400 | -0.046200 | 9.14e-03 | 3.89e-01 | 1.88e-01 | 6.19e-01 | 6.04e-01 |
| DEATH RECEPTOR SIGNALLING | 133 | 1.11e-04 | 7.73e-04 | 0.2790 | -4.32e-02 | -0.022400 | 0.215000 | 0.124000 | 0.118000 | 3.90e-01 | 6.55e-01 | 1.92e-05 | 1.35e-02 | 1.90e-02 |
| NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS | 12 | 4.97e-01 | 5.87e-01 | 0.2790 | 1.68e-01 | 0.109000 | 0.138000 | -0.123000 | 0.058700 | 3.14e-01 | 5.15e-01 | 4.09e-01 | 4.60e-01 | 7.25e-01 |
| FORMATION OF INCISION COMPLEX IN GG NER | 43 | 2.56e-01 | 3.65e-01 | 0.2790 | -9.69e-03 | 0.157000 | -0.115000 | 0.032300 | -0.196000 | 9.13e-01 | 7.57e-02 | 1.91e-01 | 7.14e-01 | 2.59e-02 |
| STIMULI SENSING CHANNELS | 71 | 6.59e-02 | 1.38e-01 | 0.2780 | -7.53e-02 | -0.164000 | 0.196000 | 0.022900 | 0.075200 | 2.73e-01 | 1.68e-02 | 4.27e-03 | 7.38e-01 | 2.73e-01 |
| DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS | 19 | 4.48e-01 | 5.41e-01 | 0.2780 | -2.32e-01 | -0.009570 | -0.002230 | -0.130000 | -0.081000 | 8.03e-02 | 9.42e-01 | 9.87e-01 | 3.27e-01 | 5.41e-01 |
| REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE | 75 | 1.20e-02 | 3.62e-02 | 0.2780 | -1.46e-01 | 0.067400 | -0.045000 | 0.177000 | -0.134000 | 2.91e-02 | 3.13e-01 | 5.01e-01 | 8.07e-03 | 4.45e-02 |
| G ALPHA I SIGNALLING EVENTS | 179 | 2.02e-10 | 6.02e-09 | 0.2770 | -6.58e-02 | 0.172000 | -0.015000 | 0.168000 | 0.120000 | 1.30e-01 | 7.19e-05 | 7.29e-01 | 1.06e-04 | 5.57e-03 |
| ONCOGENE INDUCED SENESCENCE | 32 | 3.76e-01 | 4.79e-01 | 0.2770 | 1.28e-01 | -0.065900 | 0.141000 | 0.048800 | 0.184000 | 2.10e-01 | 5.19e-01 | 1.66e-01 | 6.33e-01 | 7.21e-02 |
| NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | 17 | 7.48e-01 | 7.93e-01 | 0.2770 | 4.80e-02 | 0.193000 | -0.143000 | -0.050800 | -0.121000 | 7.32e-01 | 1.69e-01 | 3.09e-01 | 7.17e-01 | 3.87e-01 |
| METABOLISM OF RNA | 643 | 9.34e-19 | 4.92e-17 | 0.2770 | 1.20e-01 | 0.106000 | -0.186000 | -0.077300 | -0.104000 | 2.69e-07 | 5.39e-06 | 1.29e-15 | 8.85e-04 | 7.32e-06 |
| SUMOYLATION OF TRANSCRIPTION FACTORS | 16 | 2.07e-01 | 3.11e-01 | 0.2770 | -7.22e-03 | 0.250000 | 0.022600 | -0.103000 | -0.052800 | 9.60e-01 | 8.30e-02 | 8.76e-01 | 4.76e-01 | 7.15e-01 |
| ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION | 14 | 5.03e-01 | 5.91e-01 | 0.2770 | -1.55e-01 | 0.137000 | -0.079200 | 0.158000 | 0.051600 | 3.17e-01 | 3.74e-01 | 6.08e-01 | 3.06e-01 | 7.38e-01 |
| SLC MEDIATED TRANSMEMBRANE TRANSPORT | 176 | 9.91e-07 | 1.14e-05 | 0.2770 | 4.08e-02 | 0.066100 | 0.139000 | 0.168000 | 0.152000 | 3.52e-01 | 1.31e-01 | 1.54e-03 | 1.27e-04 | 5.00e-04 |
| POTASSIUM CHANNELS | 88 | 3.83e-04 | 2.14e-03 | 0.2770 | -2.58e-01 | -0.011600 | 0.065000 | 0.012500 | 0.074600 | 2.97e-05 | 8.51e-01 | 2.93e-01 | 8.40e-01 | 2.26e-01 |
| ION TRANSPORT BY P TYPE ATPASES | 47 | 2.25e-01 | 3.34e-01 | 0.2770 | -1.42e-02 | -0.073200 | 0.173000 | 0.078200 | 0.186000 | 8.66e-01 | 3.86e-01 | 3.98e-02 | 3.54e-01 | 2.72e-02 |
| TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL | 43 | 5.33e-02 | 1.18e-01 | 0.2760 | -8.46e-03 | -0.196000 | -0.041800 | -0.169000 | -0.087200 | 9.24e-01 | 2.61e-02 | 6.35e-01 | 5.57e-02 | 3.23e-01 |
| NEGATIVE REGULATION OF MAPK PATHWAY | 41 | 1.06e-01 | 1.95e-01 | 0.2760 | -1.26e-01 | 0.146000 | -0.013700 | 0.136000 | -0.142000 | 1.61e-01 | 1.05e-01 | 8.79e-01 | 1.31e-01 | 1.16e-01 |
| REGULATION OF TP53 ACTIVITY THROUGH METHYLATION | 18 | 6.26e-01 | 6.93e-01 | 0.2760 | -3.12e-02 | -0.182000 | 0.175000 | -0.107000 | 0.011300 | 8.19e-01 | 1.81e-01 | 2.00e-01 | 4.34e-01 | 9.34e-01 |
| MET ACTIVATES PTK2 SIGNALING | 28 | 5.91e-01 | 6.62e-01 | 0.2760 | -3.84e-02 | -0.147000 | 0.200000 | 0.018100 | 0.111000 | 7.25e-01 | 1.79e-01 | 6.65e-02 | 8.68e-01 | 3.08e-01 |
| TBC RABGAPS | 43 | 4.11e-02 | 9.65e-02 | 0.2750 | -1.01e-01 | 0.107000 | 0.124000 | 0.196000 | -0.023600 | 2.53e-01 | 2.23e-01 | 1.61e-01 | 2.64e-02 | 7.89e-01 |
| SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS | 73 | 4.53e-03 | 1.68e-02 | 0.2750 | -2.50e-01 | 0.029300 | 0.017100 | 0.087100 | -0.067700 | 2.27e-04 | 6.66e-01 | 8.01e-01 | 1.98e-01 | 3.18e-01 |
| STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES | 14 | 5.27e-01 | 6.13e-01 | 0.2750 | 8.57e-02 | -0.187000 | 0.089800 | -0.142000 | -0.068100 | 5.79e-01 | 2.25e-01 | 5.61e-01 | 3.56e-01 | 6.59e-01 |
| GAP JUNCTION TRAFFICKING AND REGULATION | 33 | 4.64e-01 | 5.56e-01 | 0.2740 | 4.39e-02 | 0.210000 | -0.130000 | 0.083600 | -0.072600 | 6.63e-01 | 3.68e-02 | 1.96e-01 | 4.06e-01 | 4.70e-01 |
| TRANSMISSION ACROSS CHEMICAL SYNAPSES | 233 | 3.51e-12 | 1.17e-10 | 0.2730 | -1.67e-01 | 0.038500 | 0.044800 | 0.172000 | 0.117000 | 1.23e-05 | 3.12e-01 | 2.39e-01 | 5.99e-06 | 2.17e-03 |
| METABOLISM OF NUCLEOTIDES | 91 | 2.75e-02 | 6.97e-02 | 0.2730 | 1.32e-01 | 0.141000 | -0.120000 | 0.121000 | -0.090200 | 3.00e-02 | 1.99e-02 | 4.75e-02 | 4.63e-02 | 1.37e-01 |
| RUNX2 REGULATES BONE DEVELOPMENT | 29 | 3.14e-01 | 4.20e-01 | 0.2730 | 9.43e-02 | 0.067000 | 0.138000 | 0.050900 | 0.198000 | 3.79e-01 | 5.32e-01 | 1.99e-01 | 6.35e-01 | 6.45e-02 |
| DISEASES OF IMMUNE SYSTEM | 23 | 4.18e-01 | 5.15e-01 | 0.2730 | 2.34e-01 | 0.138000 | 0.003550 | -0.019500 | 0.003940 | 5.19e-02 | 2.52e-01 | 9.76e-01 | 8.72e-01 | 9.74e-01 |
| NEGATIVE REGULATION OF FGFR1 SIGNALING | 25 | 3.22e-01 | 4.27e-01 | 0.2730 | -6.79e-02 | 0.191000 | 0.002050 | 0.138000 | -0.119000 | 5.57e-01 | 9.86e-02 | 9.86e-01 | 2.33e-01 | 3.01e-01 |
| TERMINATION OF TRANSLESION DNA SYNTHESIS | 30 | 3.39e-01 | 4.44e-01 | 0.2720 | 5.88e-02 | 0.034000 | -0.227000 | -0.070500 | -0.113000 | 5.78e-01 | 7.47e-01 | 3.13e-02 | 5.04e-01 | 2.86e-01 |
| CHROMOSOME MAINTENANCE | 100 | 3.64e-03 | 1.42e-02 | 0.2710 | 1.46e-01 | 0.053000 | -0.151000 | -0.089000 | -0.136000 | 1.15e-02 | 3.60e-01 | 9.05e-03 | 1.24e-01 | 1.85e-02 |
| REGULATION OF INSULIN SECRETION | 71 | 1.21e-03 | 5.88e-03 | 0.2710 | -6.60e-05 | 0.090700 | 0.037000 | 0.130000 | 0.217000 | 9.99e-01 | 1.87e-01 | 5.90e-01 | 5.92e-02 | 1.60e-03 |
| JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | 22 | 2.92e-01 | 4.02e-01 | 0.2710 | -1.71e-01 | 0.135000 | 0.064200 | 0.136000 | -0.056500 | 1.66e-01 | 2.72e-01 | 6.02e-01 | 2.68e-01 | 6.46e-01 |
| PREGNENOLONE BIOSYNTHESIS | 12 | 7.05e-01 | 7.57e-01 | 0.2710 | 1.81e-01 | 0.015400 | -0.057600 | -0.155000 | -0.114000 | 2.78e-01 | 9.26e-01 | 7.30e-01 | 3.53e-01 | 4.94e-01 |
| RHOJ GTPASE CYCLE | 54 | 1.99e-02 | 5.48e-02 | 0.2710 | -9.41e-02 | 0.111000 | -0.012000 | 0.219000 | 0.062500 | 2.32e-01 | 1.58e-01 | 8.79e-01 | 5.40e-03 | 4.27e-01 |
| RAB GEFS EXCHANGE GTP FOR GDP ON RABS | 87 | 3.07e-03 | 1.25e-02 | 0.2700 | -5.42e-02 | 0.110000 | 0.033600 | 0.220000 | -0.092700 | 3.82e-01 | 7.68e-02 | 5.88e-01 | 4.00e-04 | 1.35e-01 |
| SIALIC ACID METABOLISM | 32 | 3.42e-01 | 4.46e-01 | 0.2700 | -1.01e-01 | 0.136000 | -0.048000 | 0.145000 | -0.144000 | 3.21e-01 | 1.84e-01 | 6.38e-01 | 1.55e-01 | 1.58e-01 |
| LAMININ INTERACTIONS | 27 | 2.31e-01 | 3.41e-01 | 0.2700 | -5.27e-02 | -0.044900 | 0.236000 | -0.079100 | 0.076200 | 6.36e-01 | 6.86e-01 | 3.35e-02 | 4.77e-01 | 4.93e-01 |
| HEME SIGNALING | 44 | 2.44e-01 | 3.54e-01 | 0.2690 | -1.54e-01 | -0.194000 | 0.102000 | -0.022800 | 0.013600 | 7.68e-02 | 2.62e-02 | 2.40e-01 | 7.93e-01 | 8.76e-01 |
| BASE EXCISION REPAIR AP SITE FORMATION | 28 | 3.07e-01 | 4.15e-01 | 0.2690 | -1.10e-02 | -0.136000 | -0.078200 | -0.218000 | 0.007410 | 9.20e-01 | 2.14e-01 | 4.74e-01 | 4.58e-02 | 9.46e-01 |
| RHOQ GTPASE CYCLE | 57 | 1.12e-02 | 3.46e-02 | 0.2680 | -8.69e-02 | 0.155000 | 0.083200 | 0.181000 | -0.028400 | 2.57e-01 | 4.26e-02 | 2.77e-01 | 1.83e-02 | 7.11e-01 |
| INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING | 76 | 1.14e-02 | 3.49e-02 | 0.2680 | 1.15e-01 | 0.188000 | -0.127000 | 0.066500 | 0.055200 | 8.36e-02 | 4.71e-03 | 5.59e-02 | 3.17e-01 | 4.06e-01 |
| NEDDYLATION | 212 | 6.19e-05 | 4.61e-04 | 0.2680 | 7.08e-02 | 0.151000 | -0.105000 | 0.100000 | -0.152000 | 7.61e-02 | 1.51e-04 | 8.32e-03 | 1.22e-02 | 1.47e-04 |
| RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL | 59 | 1.20e-01 | 2.13e-01 | 0.2670 | 3.71e-02 | 0.160000 | -0.170000 | -0.084200 | -0.089700 | 6.22e-01 | 3.35e-02 | 2.39e-02 | 2.64e-01 | 2.33e-01 |
| SIGNALING BY EGFR | 46 | 5.99e-02 | 1.27e-01 | 0.2660 | 3.17e-02 | 0.142000 | 0.096400 | 0.145000 | 0.139000 | 7.10e-01 | 9.53e-02 | 2.58e-01 | 8.93e-02 | 1.02e-01 |
| FGFR1 MUTANT RECEPTOR ACTIVATION | 25 | 2.38e-01 | 3.47e-01 | 0.2660 | -1.96e-01 | 0.098600 | 0.030100 | 0.137000 | 0.054400 | 8.98e-02 | 3.93e-01 | 7.94e-01 | 2.37e-01 | 6.38e-01 |
| INSULIN RECEPTOR SIGNALLING CASCADE | 41 | 7.41e-02 | 1.50e-01 | 0.2650 | -1.30e-01 | 0.167000 | 0.011400 | 0.115000 | -0.109000 | 1.49e-01 | 6.40e-02 | 9.00e-01 | 2.01e-01 | 2.27e-01 |
| SIGNALING BY FLT3 FUSION PROTEINS | 18 | 2.37e-01 | 3.47e-01 | 0.2650 | -1.16e-01 | -0.089100 | -0.086300 | -0.087200 | 0.184000 | 3.96e-01 | 5.13e-01 | 5.26e-01 | 5.22e-01 | 1.78e-01 |
| HS GAG BIOSYNTHESIS | 29 | 3.12e-01 | 4.18e-01 | 0.2650 | 7.70e-02 | 0.129000 | 0.105000 | 0.159000 | 0.106000 | 4.73e-01 | 2.29e-01 | 3.30e-01 | 1.38e-01 | 3.25e-01 |
| ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | 28 | 2.65e-01 | 3.74e-01 | 0.2640 | -7.14e-02 | -0.002590 | 0.036300 | 0.207000 | -0.143000 | 5.14e-01 | 9.81e-01 | 7.40e-01 | 5.81e-02 | 1.89e-01 |
| RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE | 21 | 5.30e-01 | 6.15e-01 | 0.2640 | 4.06e-02 | -0.054000 | -0.080200 | -0.241000 | -0.027500 | 7.47e-01 | 6.69e-01 | 5.25e-01 | 5.63e-02 | 8.27e-01 |
| EPHB MEDIATED FORWARD SIGNALING | 42 | 2.59e-01 | 3.69e-01 | 0.2630 | 4.23e-02 | 0.187000 | -0.034200 | 0.165000 | -0.064300 | 6.36e-01 | 3.64e-02 | 7.02e-01 | 6.38e-02 | 4.71e-01 |
| HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 51 | 1.12e-01 | 2.03e-01 | 0.2630 | 8.28e-02 | 0.024700 | 0.111000 | 0.118000 | 0.188000 | 3.06e-01 | 7.60e-01 | 1.72e-01 | 1.45e-01 | 2.01e-02 |
| MRNA SPLICING | 188 | 6.46e-05 | 4.68e-04 | 0.2620 | 6.23e-02 | 0.120000 | -0.184000 | -0.100000 | -0.081800 | 1.41e-01 | 4.63e-03 | 1.45e-05 | 1.79e-02 | 5.36e-02 |
| REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION | 84 | 9.35e-03 | 2.98e-02 | 0.2620 | -2.03e-01 | -0.102000 | -0.008210 | -0.046500 | -0.122000 | 1.33e-03 | 1.07e-01 | 8.97e-01 | 4.61e-01 | 5.26e-02 |
| ERBB2 ACTIVATES PTK6 SIGNALING | 10 | 8.41e-01 | 8.72e-01 | 0.2610 | -3.22e-02 | -0.089400 | 0.215000 | 0.114000 | 0.019600 | 8.60e-01 | 6.24e-01 | 2.40e-01 | 5.34e-01 | 9.14e-01 |
| RND1 GTPASE CYCLE | 37 | 2.31e-01 | 3.41e-01 | 0.2610 | -1.44e-01 | -0.111000 | 0.094200 | 0.156000 | 0.043900 | 1.29e-01 | 2.43e-01 | 3.21e-01 | 1.00e-01 | 6.44e-01 |
| SYNDECAN INTERACTIONS | 26 | 2.50e-01 | 3.60e-01 | 0.2610 | 9.14e-02 | 0.212000 | -0.028800 | 0.002810 | 0.119000 | 4.20e-01 | 6.12e-02 | 8.00e-01 | 9.80e-01 | 2.94e-01 |
| HDR THROUGH HOMOLOGOUS RECOMBINATION HRR | 62 | 3.07e-02 | 7.60e-02 | 0.2610 | -5.59e-02 | -0.077000 | -0.118000 | -0.084000 | -0.195000 | 4.47e-01 | 2.94e-01 | 1.09e-01 | 2.53e-01 | 7.80e-03 |
| FOXO MEDIATED TRANSCRIPTION | 56 | 4.08e-02 | 9.64e-02 | 0.2610 | 1.23e-01 | 0.193000 | -0.097500 | -0.025900 | 0.075100 | 1.11e-01 | 1.26e-02 | 2.07e-01 | 7.37e-01 | 3.31e-01 |
| INFECTIOUS DISEASE | 711 | 4.79e-18 | 2.28e-16 | 0.2610 | 1.12e-01 | 0.189000 | -0.134000 | 0.020900 | -0.034400 | 4.04e-07 | 1.12e-17 | 1.63e-09 | 3.46e-01 | 1.20e-01 |
| HIV ELONGATION ARREST AND RECOVERY | 32 | 1.89e-01 | 2.91e-01 | 0.2610 | 1.30e-02 | 0.003970 | 0.013300 | -0.257000 | 0.035400 | 8.99e-01 | 9.69e-01 | 8.97e-01 | 1.17e-02 | 7.29e-01 |
| RNA POLYMERASE II TRANSCRIPTION TERMINATION | 65 | 2.49e-02 | 6.48e-02 | 0.2600 | 3.71e-02 | 0.002600 | -0.085400 | -0.215000 | -0.113000 | 6.05e-01 | 9.71e-01 | 2.34e-01 | 2.70e-03 | 1.15e-01 |
| NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION | 64 | 3.45e-02 | 8.37e-02 | 0.2600 | 1.63e-01 | 0.044700 | -0.096700 | -0.147000 | -0.090800 | 2.42e-02 | 5.37e-01 | 1.81e-01 | 4.21e-02 | 2.09e-01 |
| SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III | 23 | 5.86e-01 | 6.57e-01 | 0.2590 | 1.04e-01 | 0.067000 | -0.111000 | 0.104000 | -0.169000 | 3.90e-01 | 5.78e-01 | 3.55e-01 | 3.87e-01 | 1.61e-01 |
| ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE | 96 | 1.33e-02 | 3.94e-02 | 0.2590 | -1.64e-01 | -0.174000 | 0.071600 | -0.061800 | -0.026600 | 5.50e-03 | 3.20e-03 | 2.25e-01 | 2.96e-01 | 6.52e-01 |
| UNFOLDED PROTEIN RESPONSE UPR | 84 | 3.96e-03 | 1.52e-02 | 0.2580 | 5.16e-02 | 0.146000 | 0.093200 | 0.158000 | 0.095200 | 4.14e-01 | 2.09e-02 | 1.40e-01 | 1.22e-02 | 1.32e-01 |
| INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING | 41 | 1.18e-01 | 2.11e-01 | 0.2580 | 5.87e-02 | 0.119000 | 0.100000 | 0.090000 | 0.175000 | 5.15e-01 | 1.89e-01 | 2.66e-01 | 3.19e-01 | 5.23e-02 |
| CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | 12 | 5.42e-01 | 6.23e-01 | 0.2570 | -3.58e-02 | -0.154000 | -0.042800 | -0.029100 | 0.196000 | 8.30e-01 | 3.55e-01 | 7.98e-01 | 8.61e-01 | 2.40e-01 |
| MTOR SIGNALLING | 40 | 2.49e-01 | 3.59e-01 | 0.2570 | -3.13e-03 | 0.071000 | -0.057600 | 0.213000 | -0.110000 | 9.73e-01 | 4.38e-01 | 5.28e-01 | 1.96e-02 | 2.27e-01 |
| TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST | 13 | 6.90e-01 | 7.45e-01 | 0.2560 | -8.54e-02 | -0.072000 | 0.018200 | -0.175000 | -0.149000 | 5.94e-01 | 6.53e-01 | 9.10e-01 | 2.75e-01 | 3.51e-01 |
| AMYLOID FIBER FORMATION | 55 | 3.25e-02 | 7.95e-02 | 0.2560 | 1.67e-01 | 0.169000 | -0.016200 | -0.094400 | 0.012800 | 3.22e-02 | 3.06e-02 | 8.36e-01 | 2.26e-01 | 8.70e-01 |
| FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 117 | 3.07e-03 | 1.25e-02 | 0.2560 | -9.13e-02 | -0.048200 | 0.175000 | 0.127000 | 0.090800 | 8.82e-02 | 3.68e-01 | 1.09e-03 | 1.78e-02 | 9.02e-02 |
| CLATHRIN MEDIATED ENDOCYTOSIS | 129 | 2.11e-04 | 1.31e-03 | 0.2560 | -8.63e-02 | 0.118000 | 0.024100 | 0.207000 | -0.027300 | 9.10e-02 | 2.12e-02 | 6.37e-01 | 4.83e-05 | 5.93e-01 |
| SIGNALING BY ERYTHROPOIETIN | 24 | 9.70e-02 | 1.82e-01 | 0.2560 | -5.78e-02 | 0.190000 | 0.106000 | -0.023200 | 0.118000 | 6.24e-01 | 1.06e-01 | 3.67e-01 | 8.44e-01 | 3.16e-01 |
| TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | 31 | 2.61e-01 | 3.72e-01 | 0.2560 | 3.75e-02 | 0.102000 | 0.124000 | 0.195000 | 0.014900 | 7.18e-01 | 3.24e-01 | 2.34e-01 | 6.07e-02 | 8.86e-01 |
| NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | 11 | 9.26e-01 | 9.41e-01 | 0.2550 | 3.67e-02 | 0.197000 | -0.104000 | 0.101000 | -0.062900 | 8.33e-01 | 2.57e-01 | 5.51e-01 | 5.63e-01 | 7.18e-01 |
| NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | 48 | 2.51e-01 | 3.60e-01 | 0.2540 | -2.76e-02 | -0.044500 | 0.147000 | 0.001970 | 0.200000 | 7.41e-01 | 5.94e-01 | 7.86e-02 | 9.81e-01 | 1.64e-02 |
| FCERI MEDIATED CA 2 MOBILIZATION | 26 | 2.12e-01 | 3.18e-01 | 0.2540 | 5.98e-04 | 0.252000 | -0.010800 | 0.019300 | -0.021500 | 9.96e-01 | 2.64e-02 | 9.24e-01 | 8.65e-01 | 8.50e-01 |
| RNA POLYMERASE I TRANSCRIPTION | 66 | 2.93e-02 | 7.27e-02 | 0.2530 | 1.99e-01 | 0.056500 | -0.052200 | -0.130000 | -0.036900 | 5.10e-03 | 4.28e-01 | 4.64e-01 | 6.72e-02 | 6.04e-01 |
| AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS | 10 | 6.97e-01 | 7.51e-01 | 0.2530 | -6.78e-02 | 0.012800 | 0.241000 | 0.029600 | 0.021700 | 7.10e-01 | 9.44e-01 | 1.88e-01 | 8.71e-01 | 9.06e-01 |
| SIGNALING BY FGFR1 | 42 | 1.84e-01 | 2.87e-01 | 0.2530 | -4.92e-02 | 0.216000 | -0.080900 | 0.065100 | -0.062500 | 5.81e-01 | 1.53e-02 | 3.64e-01 | 4.66e-01 | 4.84e-01 |
| DAP12 SIGNALING | 24 | 3.08e-01 | 4.15e-01 | 0.2520 | 6.97e-02 | 0.191000 | -0.088700 | -0.053800 | 0.106000 | 5.55e-01 | 1.05e-01 | 4.52e-01 | 6.48e-01 | 3.71e-01 |
| NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION | 175 | 2.30e-07 | 2.90e-06 | 0.2520 | -1.59e-01 | 0.028100 | 0.031300 | 0.170000 | 0.085600 | 2.84e-04 | 5.22e-01 | 4.75e-01 | 1.09e-04 | 5.12e-02 |
| VITAMIN B5 PANTOTHENATE METABOLISM | 14 | 7.12e-01 | 7.63e-01 | 0.2510 | -5.50e-02 | 0.123000 | 0.067900 | 0.188000 | -0.070900 | 7.22e-01 | 4.25e-01 | 6.60e-01 | 2.23e-01 | 6.46e-01 |
| BASIGIN INTERACTIONS | 22 | 3.46e-01 | 4.51e-01 | 0.2510 | -1.15e-01 | 0.152000 | -0.071400 | 0.137000 | 0.056400 | 3.51e-01 | 2.18e-01 | 5.62e-01 | 2.67e-01 | 6.47e-01 |
| POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION | 61 | 3.41e-02 | 8.30e-02 | 0.2510 | 1.66e-01 | 0.029800 | -0.014600 | -0.185000 | 0.010900 | 2.54e-02 | 6.88e-01 | 8.44e-01 | 1.24e-02 | 8.83e-01 |
| DISEASES OF MITOTIC CELL CYCLE | 37 | 1.14e-01 | 2.06e-01 | 0.2510 | 6.58e-02 | -0.062900 | -0.147000 | 0.014700 | -0.181000 | 4.89e-01 | 5.08e-01 | 1.23e-01 | 8.77e-01 | 5.69e-02 |
| CD209 DC SIGN SIGNALING | 18 | 7.25e-01 | 7.75e-01 | 0.2500 | 2.61e-02 | 0.206000 | -0.078400 | 0.115000 | -0.000582 | 8.48e-01 | 1.30e-01 | 5.65e-01 | 3.96e-01 | 9.97e-01 |
| REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA | 13 | 7.09e-01 | 7.60e-01 | 0.2500 | 1.98e-01 | -0.045000 | 0.097600 | -0.105000 | 0.022600 | 2.16e-01 | 7.79e-01 | 5.42e-01 | 5.12e-01 | 8.88e-01 |
| TP53 REGULATES METABOLIC GENES | 84 | 4.12e-02 | 9.66e-02 | 0.2500 | 3.33e-02 | 0.143000 | -0.124000 | -0.084100 | -0.137000 | 5.98e-01 | 2.41e-02 | 5.02e-02 | 1.83e-01 | 3.07e-02 |
| SIGNALING BY NTRKS | 128 | 3.84e-05 | 3.10e-04 | 0.2490 | -1.79e-01 | 0.072300 | 0.057700 | 0.141000 | 0.042300 | 4.78e-04 | 1.58e-01 | 2.60e-01 | 5.95e-03 | 4.09e-01 |
| METABOLISM OF CARBOHYDRATES | 255 | 3.66e-09 | 7.19e-08 | 0.2490 | -3.46e-03 | 0.158000 | 0.040700 | 0.179000 | 0.056100 | 9.24e-01 | 1.42e-05 | 2.64e-01 | 8.50e-07 | 1.24e-01 |
| SIGNALING BY GPCR | 437 | 4.03e-18 | 2.03e-16 | 0.2480 | -6.79e-02 | 0.082900 | 0.089600 | 0.139000 | 0.150000 | 1.53e-02 | 3.06e-03 | 1.38e-03 | 7.15e-07 | 7.84e-08 |
| AUTOPHAGY | 137 | 5.72e-03 | 2.01e-02 | 0.2480 | 3.83e-02 | 0.150000 | -0.074400 | 0.165000 | -0.068800 | 4.40e-01 | 2.47e-03 | 1.33e-01 | 8.92e-04 | 1.65e-01 |
| DISORDERS OF TRANSMEMBRANE TRANSPORTERS | 135 | 4.96e-03 | 1.81e-02 | 0.2470 | 6.07e-02 | 0.163000 | -0.109000 | 0.135000 | -0.029800 | 2.24e-01 | 1.12e-03 | 2.87e-02 | 6.93e-03 | 5.51e-01 |
| SIGNALING BY FGFR1 IN DISEASE | 32 | 1.43e-01 | 2.42e-01 | 0.2470 | -1.55e-01 | 0.159000 | -0.014900 | 0.100000 | 0.038400 | 1.30e-01 | 1.20e-01 | 8.84e-01 | 3.27e-01 | 7.07e-01 |
| SIGNALING BY NODAL | 14 | 5.44e-01 | 6.24e-01 | 0.2460 | -6.93e-02 | 0.137000 | 0.103000 | 0.034100 | 0.159000 | 6.54e-01 | 3.74e-01 | 5.06e-01 | 8.25e-01 | 3.02e-01 |
| CA2 PATHWAY | 56 | 2.01e-02 | 5.48e-02 | 0.2460 | 9.41e-02 | 0.065600 | -0.017100 | -0.031300 | 0.215000 | 2.23e-01 | 3.96e-01 | 8.25e-01 | 6.86e-01 | 5.38e-03 |
| DNA STRAND ELONGATION | 32 | 6.00e-01 | 6.69e-01 | 0.2460 | 6.93e-02 | 0.126000 | -0.117000 | 0.138000 | -0.084800 | 4.98e-01 | 2.19e-01 | 2.52e-01 | 1.75e-01 | 4.06e-01 |
| CYCLIN D ASSOCIATED EVENTS IN G1 | 45 | 4.51e-01 | 5.43e-01 | 0.2460 | 2.21e-02 | 0.119000 | -0.113000 | 0.115000 | -0.140000 | 7.98e-01 | 1.66e-01 | 1.90e-01 | 1.82e-01 | 1.04e-01 |
| MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | 15 | 6.52e-01 | 7.10e-01 | 0.2460 | -3.65e-02 | -0.031200 | -0.039000 | -0.079500 | -0.224000 | 8.07e-01 | 8.35e-01 | 7.94e-01 | 5.94e-01 | 1.33e-01 |
| RHO GTPASES ACTIVATE PAKS | 21 | 6.23e-01 | 6.91e-01 | 0.2450 | 1.12e-01 | 0.151000 | -0.141000 | -0.062100 | 0.031900 | 3.76e-01 | 2.30e-01 | 2.62e-01 | 6.22e-01 | 8.00e-01 |
| ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS | 23 | 2.51e-01 | 3.60e-01 | 0.2450 | -6.35e-02 | 0.090900 | -0.002450 | -0.158000 | -0.151000 | 5.98e-01 | 4.51e-01 | 9.84e-01 | 1.90e-01 | 2.09e-01 |
| DEADENYLATION OF MRNA | 25 | 3.60e-01 | 4.65e-01 | 0.2430 | -5.25e-02 | -0.010100 | -0.082900 | 0.212000 | -0.069100 | 6.50e-01 | 9.30e-01 | 4.73e-01 | 6.72e-02 | 5.50e-01 |
| INTEGRIN CELL SURFACE INTERACTIONS | 67 | 4.05e-03 | 1.54e-02 | 0.2430 | -7.24e-03 | -0.036100 | 0.123000 | -0.206000 | -0.014700 | 9.18e-01 | 6.10e-01 | 8.21e-02 | 3.55e-03 | 8.36e-01 |
| TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 30 | 1.88e-01 | 2.90e-01 | 0.2430 | 1.80e-01 | 0.121000 | 0.098700 | -0.036100 | 0.030000 | 8.80e-02 | 2.51e-01 | 3.50e-01 | 7.33e-01 | 7.76e-01 |
| ASSEMBLY OF THE HIV VIRION | 16 | 8.66e-01 | 8.91e-01 | 0.2420 | 1.29e-01 | 0.101000 | -0.163000 | 0.001560 | -0.072900 | 3.72e-01 | 4.83e-01 | 2.59e-01 | 9.91e-01 | 6.14e-01 |
| INTERFERON ALPHA BETA SIGNALING | 51 | 8.84e-02 | 1.71e-01 | 0.2420 | 1.56e-01 | 0.030300 | -0.046800 | -0.109000 | 0.139000 | 5.44e-02 | 7.08e-01 | 5.63e-01 | 1.80e-01 | 8.56e-02 |
| TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE | 63 | 1.82e-01 | 2.85e-01 | 0.2420 | -5.68e-03 | 0.103000 | -0.074800 | 0.135000 | -0.154000 | 9.38e-01 | 1.57e-01 | 3.05e-01 | 6.35e-02 | 3.40e-02 |
| SIGNALING BY VEGF | 101 | 7.90e-04 | 4.09e-03 | 0.2420 | -7.82e-02 | 0.155000 | 0.058700 | 0.157000 | -0.006410 | 1.75e-01 | 7.12e-03 | 3.09e-01 | 6.36e-03 | 9.11e-01 |
| G ALPHA Q SIGNALLING EVENTS | 142 | 3.81e-06 | 3.91e-05 | 0.2420 | 2.03e-03 | 0.128000 | -0.001550 | 0.128000 | 0.161000 | 9.67e-01 | 8.68e-03 | 9.75e-01 | 8.79e-03 | 9.70e-04 |
| TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE | 13 | 8.67e-01 | 8.91e-01 | 0.2410 | 1.21e-01 | 0.081400 | -0.090400 | 0.026700 | -0.167000 | 4.50e-01 | 6.11e-01 | 5.73e-01 | 8.68e-01 | 2.97e-01 |
| TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS | 44 | 1.96e-01 | 2.98e-01 | 0.2410 | 6.96e-02 | 0.196000 | -0.011400 | 0.111000 | 0.049700 | 4.25e-01 | 2.47e-02 | 8.96e-01 | 2.04e-01 | 5.68e-01 |
| GPCR LIGAND BINDING | 224 | 6.84e-10 | 1.80e-08 | 0.2400 | 1.75e-02 | 0.140000 | -0.012300 | 0.109000 | 0.160000 | 6.52e-01 | 3.22e-04 | 7.52e-01 | 5.09e-03 | 3.88e-05 |
| MRNA CAPPING | 29 | 3.56e-01 | 4.60e-01 | 0.2390 | 9.05e-02 | 0.028300 | -0.072200 | -0.010100 | -0.207000 | 3.99e-01 | 7.92e-01 | 5.01e-01 | 9.25e-01 | 5.40e-02 |
| CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS | 89 | 8.86e-03 | 2.85e-02 | 0.2390 | -8.21e-02 | 0.162000 | -0.023800 | 0.153000 | -0.013200 | 1.81e-01 | 8.35e-03 | 6.98e-01 | 1.29e-02 | 8.29e-01 |
| NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | 58 | 2.46e-02 | 6.42e-02 | 0.2390 | -1.74e-01 | 0.125000 | 0.020700 | 0.065800 | -0.080600 | 2.22e-02 | 1.01e-01 | 7.85e-01 | 3.86e-01 | 2.89e-01 |
| TELOMERE C STRAND SYNTHESIS INITIATION | 13 | 7.03e-01 | 7.56e-01 | 0.2390 | 3.88e-02 | -0.035800 | 0.026900 | 0.203000 | -0.110000 | 8.09e-01 | 8.23e-01 | 8.67e-01 | 2.05e-01 | 4.91e-01 |
| EXTRACELLULAR MATRIX ORGANIZATION | 232 | 6.47e-06 | 6.20e-05 | 0.2380 | 5.30e-02 | -0.040600 | 0.189000 | -0.029000 | 0.125000 | 1.65e-01 | 2.88e-01 | 6.91e-07 | 4.47e-01 | 1.04e-03 |
| INTRAFLAGELLAR TRANSPORT | 49 | 8.66e-03 | 2.81e-02 | 0.2380 | 8.83e-02 | -0.218000 | 0.002040 | 0.038700 | 0.005630 | 2.85e-01 | 8.31e-03 | 9.80e-01 | 6.39e-01 | 9.46e-01 |
| VXPX CARGO TARGETING TO CILIUM | 19 | 6.27e-01 | 6.94e-01 | 0.2380 | -7.19e-02 | -0.008690 | 0.024700 | 0.226000 | 0.010100 | 5.88e-01 | 9.48e-01 | 8.52e-01 | 8.87e-02 | 9.39e-01 |
| NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING | 33 | 4.25e-01 | 5.22e-01 | 0.2370 | 9.70e-02 | 0.125000 | -0.147000 | 0.099200 | 0.004630 | 3.35e-01 | 2.14e-01 | 1.45e-01 | 3.24e-01 | 9.63e-01 |
| RAB REGULATION OF TRAFFICKING | 118 | 7.82e-04 | 4.09e-03 | 0.2370 | -5.58e-02 | 0.085800 | 0.082300 | 0.192000 | -0.043800 | 2.96e-01 | 1.08e-01 | 1.23e-01 | 3.13e-04 | 4.12e-01 |
| COPI MEDIATED ANTEROGRADE TRANSPORT | 90 | 1.26e-02 | 3.77e-02 | 0.2360 | -5.84e-02 | 0.049800 | 0.056200 | 0.211000 | -0.046900 | 3.39e-01 | 4.15e-01 | 3.57e-01 | 5.56e-04 | 4.42e-01 |
| PEPTIDE LIGAND BINDING RECEPTORS | 86 | 1.50e-04 | 9.95e-04 | 0.2360 | 3.73e-02 | 0.115000 | -0.108000 | 0.046700 | 0.165000 | 5.51e-01 | 6.50e-02 | 8.36e-02 | 4.54e-01 | 8.36e-03 |
| GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 16 | 8.36e-01 | 8.68e-01 | 0.2360 | 6.73e-03 | 0.140000 | -0.094000 | 0.162000 | -0.024400 | 9.63e-01 | 3.31e-01 | 5.15e-01 | 2.61e-01 | 8.66e-01 |
| VLDLR INTERNALISATION AND DEGRADATION | 12 | 8.56e-01 | 8.85e-01 | 0.2350 | 2.38e-02 | 0.040500 | 0.048300 | 0.224000 | -0.026300 | 8.87e-01 | 8.08e-01 | 7.72e-01 | 1.79e-01 | 8.75e-01 |
| ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY | 11 | 8.18e-01 | 8.53e-01 | 0.2350 | 2.29e-02 | 0.205000 | 0.019600 | 0.088400 | -0.066500 | 8.95e-01 | 2.38e-01 | 9.10e-01 | 6.12e-01 | 7.02e-01 |
| WNT5A DEPENDENT INTERNALIZATION OF FZD4 | 15 | 7.96e-01 | 8.35e-01 | 0.2350 | -1.24e-01 | -0.045800 | 0.145000 | 0.129000 | -0.004030 | 4.06e-01 | 7.59e-01 | 3.32e-01 | 3.87e-01 | 9.78e-01 |
| ACTIVATION OF GENE EXPRESSION BY SREBF SREBP | 43 | 1.26e-01 | 2.21e-01 | 0.2350 | 1.40e-02 | 0.016200 | 0.044400 | 0.088900 | 0.211000 | 8.74e-01 | 8.55e-01 | 6.15e-01 | 3.13e-01 | 1.65e-02 |
| ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT | 23 | 4.70e-01 | 5.61e-01 | 0.2350 | 6.74e-02 | 0.061700 | -0.023700 | -0.215000 | 0.002200 | 5.76e-01 | 6.09e-01 | 8.44e-01 | 7.47e-02 | 9.85e-01 |
| BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | 76 | 7.30e-02 | 1.48e-01 | 0.2350 | -9.57e-04 | 0.099100 | -0.046000 | 0.124000 | -0.167000 | 9.88e-01 | 1.35e-01 | 4.89e-01 | 6.28e-02 | 1.20e-02 |
| RAC2 GTPASE CYCLE | 86 | 2.72e-02 | 6.93e-02 | 0.2340 | 1.58e-02 | 0.089200 | 0.036700 | 0.212000 | 0.014700 | 8.00e-01 | 1.53e-01 | 5.57e-01 | 6.71e-04 | 8.14e-01 |
| TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 73 | 5.41e-02 | 1.19e-01 | 0.2340 | 5.82e-02 | 0.022300 | 0.159000 | -0.010500 | 0.159000 | 3.91e-01 | 7.42e-01 | 1.86e-02 | 8.77e-01 | 1.86e-02 |
| G ALPHA S SIGNALLING EVENTS | 94 | 3.71e-03 | 1.44e-02 | 0.2330 | -3.03e-02 | 0.041000 | 0.087400 | 0.049100 | 0.204000 | 6.12e-01 | 4.93e-01 | 1.43e-01 | 4.11e-01 | 6.17e-04 |
| ASPARAGINE N LINKED GLYCOSYLATION | 281 | 7.48e-07 | 8.68e-06 | 0.2330 | -7.84e-03 | 0.127000 | -0.014000 | 0.191000 | -0.041700 | 8.22e-01 | 2.69e-04 | 6.88e-01 | 4.03e-08 | 2.31e-01 |
| RHO GTPASES ACTIVATE FORMINS | 117 | 1.90e-02 | 5.28e-02 | 0.2330 | -6.00e-02 | 0.086600 | -0.074900 | 0.143000 | -0.130000 | 2.63e-01 | 1.06e-01 | 1.62e-01 | 7.40e-03 | 1.50e-02 |
| SIGNALLING TO RAS | 18 | 8.99e-01 | 9.21e-01 | 0.2330 | -6.66e-02 | -0.143000 | 0.138000 | 0.009150 | 0.102000 | 6.25e-01 | 2.95e-01 | 3.12e-01 | 9.46e-01 | 4.55e-01 |
| CLASS A 1 RHODOPSIN LIKE RECEPTORS | 151 | 6.84e-06 | 6.47e-05 | 0.2320 | 2.51e-02 | 0.145000 | -0.005040 | 0.099500 | 0.149000 | 5.94e-01 | 2.11e-03 | 9.15e-01 | 3.50e-02 | 1.54e-03 |
| SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA | 38 | 2.33e-01 | 3.42e-01 | 0.2320 | 4.48e-02 | 0.077500 | 0.138000 | 0.014900 | 0.164000 | 6.33e-01 | 4.09e-01 | 1.42e-01 | 8.74e-01 | 8.12e-02 |
| ION HOMEOSTASIS | 47 | 1.70e-01 | 2.71e-01 | 0.2320 | -1.74e-01 | -0.005880 | 0.129000 | 0.063000 | 0.051800 | 3.90e-02 | 9.44e-01 | 1.25e-01 | 4.55e-01 | 5.39e-01 |
| SIGNALING BY INTERLEUKINS | 337 | 2.07e-06 | 2.22e-05 | 0.2310 | 9.41e-02 | 0.177000 | -0.089600 | 0.064800 | -0.031500 | 3.08e-03 | 2.77e-08 | 4.82e-03 | 4.15e-02 | 3.22e-01 |
| FORMATION OF TC NER PRE INCISION COMPLEX | 53 | 2.90e-01 | 4.01e-01 | 0.2300 | 9.48e-04 | 0.094200 | -0.083800 | 0.041900 | -0.188000 | 9.90e-01 | 2.36e-01 | 2.91e-01 | 5.98e-01 | 1.79e-02 |
| MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION | 16 | 6.67e-01 | 7.22e-01 | 0.2300 | -4.43e-02 | 0.059500 | 0.137000 | 0.166000 | -0.033000 | 7.59e-01 | 6.81e-01 | 3.42e-01 | 2.51e-01 | 8.19e-01 |
| HATS ACETYLATE HISTONES | 90 | 7.37e-02 | 1.49e-01 | 0.2300 | -1.43e-01 | -0.083200 | 0.143000 | -0.000965 | 0.072700 | 1.95e-02 | 1.73e-01 | 1.94e-02 | 9.87e-01 | 2.34e-01 |
| RNA POLYMERASE III TRANSCRIPTION | 41 | 2.97e-01 | 4.07e-01 | 0.2290 | -8.76e-03 | -0.122000 | -0.051400 | -0.187000 | -0.011000 | 9.23e-01 | 1.77e-01 | 5.69e-01 | 3.84e-02 | 9.03e-01 |
| SEMA4D IN SEMAPHORIN SIGNALING | 24 | 6.51e-01 | 7.09e-01 | 0.2290 | 1.83e-01 | 0.019300 | 0.080800 | 0.003140 | 0.111000 | 1.21e-01 | 8.70e-01 | 4.93e-01 | 9.79e-01 | 3.48e-01 |
| GENERATION OF SECOND MESSENGER MOLECULES | 19 | 7.98e-01 | 8.35e-01 | 0.2290 | 1.02e-01 | 0.159000 | -0.089800 | -0.057200 | -0.073000 | 4.41e-01 | 2.29e-01 | 4.98e-01 | 6.66e-01 | 5.82e-01 |
| DNA DAMAGE BYPASS | 45 | 3.40e-01 | 4.45e-01 | 0.2280 | -6.77e-03 | 0.022800 | -0.185000 | -0.005520 | -0.132000 | 9.37e-01 | 7.91e-01 | 3.22e-02 | 9.49e-01 | 1.26e-01 |
| SUMOYLATION OF INTRACELLULAR RECEPTORS | 24 | 7.36e-01 | 7.84e-01 | 0.2280 | 1.62e-01 | 0.083800 | -0.106000 | 0.044400 | -0.074300 | 1.71e-01 | 4.77e-01 | 3.69e-01 | 7.07e-01 | 5.29e-01 |
| REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF | 56 | 7.47e-02 | 1.51e-01 | 0.2280 | -5.00e-02 | -0.011000 | 0.053000 | 0.152000 | 0.153000 | 5.17e-01 | 8.87e-01 | 4.93e-01 | 4.95e-02 | 4.81e-02 |
| DISEASES OF GLYCOSYLATION | 121 | 1.91e-02 | 5.28e-02 | 0.2280 | 5.94e-02 | -0.032900 | 0.164000 | 0.058900 | 0.129000 | 2.60e-01 | 5.32e-01 | 1.81e-03 | 2.63e-01 | 1.43e-02 |
| ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | 73 | 4.30e-02 | 1.00e-01 | 0.2270 | -1.77e-01 | -0.045600 | -0.019400 | 0.120000 | -0.055500 | 8.95e-03 | 5.01e-01 | 7.74e-01 | 7.62e-02 | 4.12e-01 |
| MITOTIC G2 G2 M PHASES | 183 | 2.09e-03 | 8.91e-03 | 0.2260 | -1.42e-02 | 0.040700 | -0.132000 | -0.010900 | -0.178000 | 7.41e-01 | 3.43e-01 | 2.10e-03 | 7.99e-01 | 3.23e-05 |
| MEMBRANE TRAFFICKING | 572 | 2.80e-15 | 1.16e-13 | 0.2260 | -6.26e-02 | 0.078600 | 0.021100 | 0.198000 | -0.037000 | 1.09e-02 | 1.38e-03 | 3.90e-01 | 8.30e-16 | 1.33e-01 |
| MITOTIC PROMETAPHASE | 174 | 1.73e-04 | 1.12e-03 | 0.2260 | -1.40e-01 | -0.027500 | -0.050600 | 0.096700 | -0.136000 | 1.42e-03 | 5.32e-01 | 2.50e-01 | 2.80e-02 | 1.95e-03 |
| TRANSCRIPTIONAL REGULATION BY VENTX | 35 | 5.14e-01 | 6.02e-01 | 0.2260 | 8.45e-02 | -0.146000 | 0.071700 | -0.093100 | 0.093100 | 3.87e-01 | 1.36e-01 | 4.63e-01 | 3.41e-01 | 3.41e-01 |
| TELOMERE MAINTENANCE | 77 | 5.62e-02 | 1.22e-01 | 0.2250 | 1.34e-01 | 0.026800 | -0.097500 | -0.109000 | -0.103000 | 4.19e-02 | 6.84e-01 | 1.39e-01 | 9.76e-02 | 1.18e-01 |
| TCF DEPENDENT SIGNALING IN RESPONSE TO WNT | 174 | 1.38e-03 | 6.47e-03 | 0.2250 | 1.29e-01 | 0.163000 | -0.082100 | -0.018600 | -0.018300 | 3.40e-03 | 2.14e-04 | 6.21e-02 | 6.73e-01 | 6.78e-01 |
| MHC CLASS II ANTIGEN PRESENTATION | 101 | 4.05e-02 | 9.58e-02 | 0.2250 | -3.86e-02 | 0.056800 | -0.105000 | 0.138000 | -0.125000 | 5.03e-01 | 3.25e-01 | 6.73e-02 | 1.63e-02 | 3.05e-02 |
| MICRORNA MIRNA BIOGENESIS | 24 | 7.07e-01 | 7.59e-01 | 0.2250 | 4.05e-02 | -0.108000 | 0.098400 | -0.157000 | 0.051400 | 7.31e-01 | 3.59e-01 | 4.04e-01 | 1.83e-01 | 6.63e-01 |
| TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE | 17 | 9.10e-01 | 9.30e-01 | 0.2240 | -1.11e-01 | -0.142000 | 0.095800 | -0.029700 | 0.086700 | 4.27e-01 | 3.09e-01 | 4.94e-01 | 8.32e-01 | 5.36e-01 |
| CELL CELL JUNCTION ORGANIZATION | 47 | 8.41e-02 | 1.64e-01 | 0.2240 | -1.92e-01 | 0.018700 | -0.058100 | 0.094200 | 0.028000 | 2.28e-02 | 8.25e-01 | 4.91e-01 | 2.64e-01 | 7.40e-01 |
| TRNA AMINOACYLATION | 42 | 3.12e-01 | 4.18e-01 | 0.2240 | 7.69e-03 | 0.042500 | -0.063400 | 0.193000 | -0.082900 | 9.31e-01 | 6.33e-01 | 4.77e-01 | 3.02e-02 | 3.53e-01 |
| SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R | 40 | 9.97e-02 | 1.86e-01 | 0.2240 | -9.69e-02 | 0.171000 | 0.023300 | 0.040700 | -0.096000 | 2.89e-01 | 6.11e-02 | 7.99e-01 | 6.56e-01 | 2.93e-01 |
| DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS | 18 | 4.02e-01 | 4.99e-01 | 0.2240 | 9.25e-02 | 0.068300 | 0.097500 | 0.083800 | -0.142000 | 4.97e-01 | 6.16e-01 | 4.74e-01 | 5.38e-01 | 2.97e-01 |
| TOLL LIKE RECEPTOR 9 TLR9 CASCADE | 90 | 9.59e-03 | 3.03e-02 | 0.2230 | -8.64e-02 | 0.086200 | 0.061000 | 0.155000 | -0.084100 | 1.57e-01 | 1.58e-01 | 3.18e-01 | 1.09e-02 | 1.68e-01 |
| RHO GTPASE CYCLE | 421 | 4.99e-11 | 1.61e-09 | 0.2230 | -5.04e-02 | 0.029800 | 0.131000 | 0.139000 | 0.098900 | 7.72e-02 | 2.96e-01 | 4.21e-06 | 1.06e-06 | 5.23e-04 |
| ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION | 105 | 3.04e-04 | 1.76e-03 | 0.2220 | -8.14e-03 | 0.120000 | 0.006140 | 0.068400 | 0.174000 | 8.86e-01 | 3.37e-02 | 9.14e-01 | 2.26e-01 | 2.07e-03 |
| CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER | 56 | 1.44e-01 | 2.42e-01 | 0.2220 | -6.03e-02 | 0.083600 | 0.050900 | 0.183000 | -0.051800 | 4.35e-01 | 2.80e-01 | 5.10e-01 | 1.79e-02 | 5.03e-01 |
| REGULATION OF LIPID METABOLISM BY PPARALPHA | 105 | 9.27e-02 | 1.77e-01 | 0.2220 | -2.66e-02 | -0.074200 | 0.169000 | 0.021300 | 0.118000 | 6.37e-01 | 1.90e-01 | 2.75e-03 | 7.06e-01 | 3.64e-02 |
| METAL ION SLC TRANSPORTERS | 24 | 3.78e-01 | 4.79e-01 | 0.2220 | 4.26e-04 | 0.151000 | 0.034400 | 0.039100 | 0.154000 | 9.97e-01 | 2.00e-01 | 7.71e-01 | 7.40e-01 | 1.92e-01 |
| NGF STIMULATED TRANSCRIPTION | 36 | 1.50e-01 | 2.48e-01 | 0.2220 | -1.62e-01 | 0.147000 | -0.021000 | -0.007990 | -0.029000 | 9.29e-02 | 1.26e-01 | 8.27e-01 | 9.34e-01 | 7.63e-01 |
| POST CHAPERONIN TUBULIN FOLDING PATHWAY | 17 | 6.55e-01 | 7.12e-01 | 0.2220 | -4.63e-03 | -0.094000 | -0.032500 | -0.085700 | -0.178000 | 9.74e-01 | 5.02e-01 | 8.17e-01 | 5.41e-01 | 2.03e-01 |
| REGULATION OF FZD BY UBIQUITINATION | 19 | 7.49e-01 | 7.93e-01 | 0.2210 | 7.86e-02 | 0.166000 | -0.071500 | 0.079200 | 0.063200 | 5.53e-01 | 2.11e-01 | 5.89e-01 | 5.50e-01 | 6.34e-01 |
| TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | 167 | 1.89e-04 | 1.21e-03 | 0.2210 | -6.08e-02 | 0.079900 | 0.064500 | 0.185000 | -0.018800 | 1.76e-01 | 7.54e-02 | 1.51e-01 | 3.69e-05 | 6.75e-01 |
| METABOLISM OF LIPIDS | 600 | 8.90e-14 | 3.23e-12 | 0.2210 | 7.66e-02 | 0.117000 | 0.010600 | 0.168000 | -0.033400 | 1.44e-03 | 1.12e-06 | 6.60e-01 | 2.80e-12 | 1.65e-01 |
| CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN | 34 | 4.68e-01 | 5.60e-01 | 0.2210 | -1.27e-01 | -0.122000 | 0.100000 | 0.077400 | -0.039000 | 1.99e-01 | 2.17e-01 | 3.12e-01 | 4.35e-01 | 6.94e-01 |
| TELOMERE EXTENSION BY TELOMERASE | 22 | 4.28e-01 | 5.23e-01 | 0.2200 | 1.33e-01 | -0.163000 | 0.033100 | -0.046900 | -0.030200 | 2.80e-01 | 1.86e-01 | 7.88e-01 | 7.03e-01 | 8.07e-01 |
| CIRCADIAN CLOCK | 68 | 1.00e-01 | 1.87e-01 | 0.2180 | -3.00e-04 | 0.051700 | 0.126000 | 0.151000 | 0.080100 | 9.97e-01 | 4.61e-01 | 7.17e-02 | 3.19e-02 | 2.53e-01 |
| TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE | 37 | 3.84e-01 | 4.84e-01 | 0.2180 | 2.56e-02 | 0.005840 | -0.190000 | -0.069900 | -0.078400 | 7.87e-01 | 9.51e-01 | 4.59e-02 | 4.62e-01 | 4.09e-01 |
| SELECTIVE AUTOPHAGY | 71 | 3.10e-01 | 4.17e-01 | 0.2180 | 3.35e-02 | 0.145000 | -0.086600 | 0.109000 | -0.077800 | 6.26e-01 | 3.46e-02 | 2.07e-01 | 1.11e-01 | 2.58e-01 |
| SIGNALING BY PDGFR IN DISEASE | 20 | 4.23e-01 | 5.20e-01 | 0.2180 | -1.56e-01 | 0.142000 | -0.027800 | 0.001070 | 0.050000 | 2.28e-01 | 2.72e-01 | 8.30e-01 | 9.93e-01 | 6.99e-01 |
| METABOLISM OF FAT SOLUBLE VITAMINS | 30 | 5.14e-01 | 6.02e-01 | 0.2180 | 1.35e-01 | 0.035700 | 0.020500 | 0.063600 | 0.153000 | 2.00e-01 | 7.35e-01 | 8.46e-01 | 5.47e-01 | 1.47e-01 |
| SIGNALING BY PDGF | 54 | 1.90e-01 | 2.93e-01 | 0.2180 | -1.30e-01 | -0.051300 | 0.162000 | -0.014900 | 0.038300 | 9.76e-02 | 5.15e-01 | 3.98e-02 | 8.50e-01 | 6.27e-01 |
| SIGNALING BY MET | 73 | 6.61e-02 | 1.38e-01 | 0.2180 | 3.53e-02 | 0.118000 | 0.074900 | 0.149000 | 0.065800 | 6.03e-01 | 8.22e-02 | 2.69e-01 | 2.73e-02 | 3.32e-01 |
| ATTENUATION PHASE | 23 | 6.62e-01 | 7.18e-01 | 0.2170 | 4.54e-02 | 0.050200 | -0.072800 | -0.160000 | -0.107000 | 7.06e-01 | 6.77e-01 | 5.46e-01 | 1.84e-01 | 3.73e-01 |
| M PHASE | 334 | 3.01e-05 | 2.51e-04 | 0.2160 | -2.70e-02 | 0.069900 | -0.120000 | 0.072900 | -0.147000 | 3.98e-01 | 2.87e-02 | 1.69e-04 | 2.23e-02 | 4.40e-06 |
| CELL CELL COMMUNICATION | 103 | 1.14e-02 | 3.49e-02 | 0.2150 | -4.77e-02 | 0.062200 | 0.083600 | 0.149000 | 0.105000 | 4.03e-01 | 2.76e-01 | 1.43e-01 | 9.06e-03 | 6.52e-02 |
| TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN | 20 | 8.21e-01 | 8.55e-01 | 0.2150 | -1.22e-01 | 0.044300 | -0.061400 | 0.064600 | -0.146000 | 3.44e-01 | 7.32e-01 | 6.35e-01 | 6.17e-01 | 2.57e-01 |
| CELLULAR RESPONSE TO HEAT STRESS | 94 | 4.73e-02 | 1.09e-01 | 0.2150 | -1.15e-01 | 0.058400 | -0.027100 | 0.143000 | -0.091700 | 5.45e-02 | 3.28e-01 | 6.50e-01 | 1.65e-02 | 1.25e-01 |
| SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS | 18 | 7.42e-01 | 7.91e-01 | 0.2150 | -1.63e-01 | -0.018200 | 0.057600 | 0.079900 | 0.097400 | 2.31e-01 | 8.93e-01 | 6.72e-01 | 5.57e-01 | 4.74e-01 |
| EGFR DOWNREGULATION | 27 | 5.35e-01 | 6.19e-01 | 0.2140 | 2.07e-03 | 0.129000 | 0.074700 | 0.153000 | 0.009120 | 9.85e-01 | 2.44e-01 | 5.02e-01 | 1.70e-01 | 9.35e-01 |
| SIGNALING BY NTRK2 TRKB | 24 | 5.47e-01 | 6.25e-01 | 0.2140 | -5.06e-02 | 0.062000 | 0.016600 | 0.164000 | 0.109000 | 6.68e-01 | 5.99e-01 | 8.88e-01 | 1.64e-01 | 3.54e-01 |
| AMINO ACIDS REGULATE MTORC1 | 51 | 4.75e-01 | 5.66e-01 | 0.2130 | -2.05e-02 | 0.118000 | -0.078300 | 0.133000 | -0.084700 | 8.01e-01 | 1.46e-01 | 3.34e-01 | 1.01e-01 | 2.95e-01 |
| PI3K AKT SIGNALING IN CANCER | 83 | 2.19e-02 | 5.83e-02 | 0.2120 | -3.63e-02 | 0.069800 | 0.112000 | 0.161000 | -0.018400 | 5.67e-01 | 2.72e-01 | 7.77e-02 | 1.13e-02 | 7.73e-01 |
| ER TO GOLGI ANTEROGRADE TRANSPORT | 139 | 1.91e-03 | 8.37e-03 | 0.2120 | -5.80e-02 | 0.049200 | 0.063600 | 0.179000 | -0.054400 | 2.39e-01 | 3.18e-01 | 1.96e-01 | 2.75e-04 | 2.68e-01 |
| UNWINDING OF DNA | 12 | 9.14e-01 | 9.32e-01 | 0.2120 | -5.66e-02 | 0.043400 | 0.008240 | 0.193000 | -0.050300 | 7.34e-01 | 7.95e-01 | 9.61e-01 | 2.48e-01 | 7.63e-01 |
| IRAK1 RECRUITS IKK COMPLEX | 14 | 8.59e-01 | 8.86e-01 | 0.2120 | 1.54e-01 | 0.133000 | 0.014000 | -0.018500 | 0.054000 | 3.19e-01 | 3.89e-01 | 9.28e-01 | 9.04e-01 | 7.26e-01 |
| TRANSCRIPTIONAL REGULATION BY RUNX1 | 175 | 1.76e-04 | 1.13e-03 | 0.2110 | 1.07e-01 | 0.025900 | 0.001580 | -0.172000 | 0.055300 | 1.47e-02 | 5.54e-01 | 9.71e-01 | 9.12e-05 | 2.07e-01 |
| CONSTITUTIVE SIGNALING BY EGFRVIII | 15 | 7.19e-01 | 7.69e-01 | 0.2110 | -1.27e-02 | 0.122000 | -0.089700 | -0.138000 | 0.050200 | 9.32e-01 | 4.14e-01 | 5.48e-01 | 3.54e-01 | 7.36e-01 |
| ONCOGENIC MAPK SIGNALING | 76 | 1.29e-01 | 2.24e-01 | 0.2110 | 3.83e-02 | 0.025800 | 0.106000 | 0.120000 | 0.130000 | 5.64e-01 | 6.97e-01 | 1.12e-01 | 7.11e-02 | 5.00e-02 |
| MYOGENESIS | 25 | 7.64e-01 | 8.07e-01 | 0.2110 | -7.24e-02 | -0.087400 | 0.109000 | 0.112000 | 0.085200 | 5.31e-01 | 4.50e-01 | 3.47e-01 | 3.31e-01 | 4.61e-01 |
| ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS | 64 | 1.82e-01 | 2.85e-01 | 0.2110 | 4.68e-02 | -0.085300 | 0.086100 | -0.160000 | 0.042200 | 5.18e-01 | 2.38e-01 | 2.34e-01 | 2.66e-02 | 5.59e-01 |
| SIGNALING BY FGFR2 | 61 | 3.40e-01 | 4.45e-01 | 0.2100 | 1.28e-01 | 0.121000 | -0.082900 | -0.022700 | -0.077500 | 8.51e-02 | 1.03e-01 | 2.63e-01 | 7.59e-01 | 2.96e-01 |
| SARS COV INFECTIONS | 139 | 4.85e-03 | 1.79e-02 | 0.2100 | 4.01e-02 | 0.182000 | -0.061200 | 0.071900 | 0.020800 | 4.15e-01 | 2.17e-04 | 2.14e-01 | 1.44e-01 | 6.72e-01 |
| ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS | 26 | 3.06e-01 | 4.15e-01 | 0.2100 | -8.84e-02 | 0.163000 | 0.014600 | 0.036800 | 0.089000 | 4.35e-01 | 1.50e-01 | 8.97e-01 | 7.45e-01 | 4.32e-01 |
| ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION | 81 | 3.51e-03 | 1.37e-02 | 0.2100 | 5.48e-03 | 0.120000 | -0.046500 | 0.047600 | 0.159000 | 9.32e-01 | 6.31e-02 | 4.70e-01 | 4.59e-01 | 1.36e-02 |
| IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | 10 | 7.01e-01 | 7.55e-01 | 0.2080 | -5.99e-02 | 0.044200 | -0.117000 | -0.012100 | 0.155000 | 7.43e-01 | 8.09e-01 | 5.22e-01 | 9.47e-01 | 3.95e-01 |
| SENSORY PROCESSING OF SOUND | 58 | 9.79e-02 | 1.83e-01 | 0.2080 | -6.95e-02 | 0.035600 | 0.130000 | -0.027000 | 0.140000 | 3.60e-01 | 6.39e-01 | 8.58e-02 | 7.22e-01 | 6.59e-02 |
| CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 337 | 3.56e-04 | 2.02e-03 | 0.2080 | 5.22e-02 | 0.121000 | -0.102000 | 0.063400 | -0.107000 | 1.01e-01 | 1.48e-04 | 1.38e-03 | 4.61e-02 | 7.34e-04 |
| REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION | 87 | 4.38e-02 | 1.02e-01 | 0.2080 | -4.04e-02 | -0.051300 | -0.070100 | -0.070000 | -0.171000 | 5.15e-01 | 4.09e-01 | 2.59e-01 | 2.60e-01 | 6.01e-03 |
| SIGNALING BY ERBB4 | 56 | 1.92e-01 | 2.95e-01 | 0.2070 | 7.46e-02 | 0.161000 | -0.065700 | 0.048200 | 0.068600 | 3.34e-01 | 3.67e-02 | 3.95e-01 | 5.33e-01 | 3.75e-01 |
| TOLL LIKE RECEPTOR CASCADES | 136 | 1.03e-02 | 3.22e-02 | 0.2070 | 7.37e-03 | 0.152000 | -0.014700 | 0.114000 | -0.081700 | 8.82e-01 | 2.28e-03 | 7.68e-01 | 2.24e-02 | 1.00e-01 |
| NON INTEGRIN MEMBRANE ECM INTERACTIONS | 55 | 2.05e-01 | 3.09e-01 | 0.2070 | 5.62e-02 | 0.013600 | 0.148000 | -0.051900 | 0.121000 | 4.71e-01 | 8.62e-01 | 5.72e-02 | 5.06e-01 | 1.20e-01 |
| ERBB2 REGULATES CELL MOTILITY | 13 | 8.38e-01 | 8.70e-01 | 0.2060 | 1.12e-01 | 0.061000 | 0.089300 | 0.130000 | -0.036100 | 4.83e-01 | 7.03e-01 | 5.77e-01 | 4.17e-01 | 8.22e-01 |
| MITOTIC PROPHASE | 91 | 4.34e-02 | 1.01e-01 | 0.2060 | -1.63e-01 | 0.054600 | -0.013200 | 0.094200 | -0.062300 | 7.23e-03 | 3.68e-01 | 8.28e-01 | 1.21e-01 | 3.05e-01 |
| RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER | 28 | 6.43e-01 | 7.05e-01 | 0.2060 | 5.81e-03 | -0.097000 | -0.016000 | -0.176000 | -0.039800 | 9.58e-01 | 3.74e-01 | 8.84e-01 | 1.06e-01 | 7.15e-01 |
| NUCLEAR SIGNALING BY ERBB4 | 30 | 6.39e-01 | 7.02e-01 | 0.2060 | 1.15e-01 | 0.077700 | 0.073700 | 0.093100 | 0.095300 | 2.77e-01 | 4.62e-01 | 4.85e-01 | 3.78e-01 | 3.66e-01 |
| HEDGEHOG OFF STATE | 106 | 1.05e-01 | 1.94e-01 | 0.2060 | 1.39e-01 | 0.124000 | -0.064500 | 0.056500 | -0.016800 | 1.34e-02 | 2.77e-02 | 2.52e-01 | 3.15e-01 | 7.66e-01 |
| L1CAM INTERACTIONS | 107 | 2.00e-02 | 5.48e-02 | 0.2050 | -1.16e-01 | 0.000535 | 0.099500 | 0.074000 | 0.116000 | 3.83e-02 | 9.92e-01 | 7.56e-02 | 1.86e-01 | 3.90e-02 |
| GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER | 83 | 2.45e-01 | 3.56e-01 | 0.2050 | -1.11e-02 | 0.126000 | -0.089000 | 0.021800 | -0.133000 | 8.62e-01 | 4.78e-02 | 1.61e-01 | 7.31e-01 | 3.68e-02 |
| SNRNP ASSEMBLY | 51 | 3.00e-01 | 4.10e-01 | 0.2050 | -1.60e-01 | -0.022000 | -0.006090 | 0.104000 | -0.070000 | 4.81e-02 | 7.86e-01 | 9.40e-01 | 1.99e-01 | 3.87e-01 |
| TRNA PROCESSING | 105 | 9.55e-03 | 3.03e-02 | 0.2040 | -1.02e-01 | -0.113000 | 0.000801 | 0.020800 | -0.134000 | 7.06e-02 | 4.48e-02 | 9.89e-01 | 7.12e-01 | 1.78e-02 |
| SIGNALING BY BRAF AND RAF FUSIONS | 60 | 3.35e-01 | 4.40e-01 | 0.2040 | -2.34e-02 | -0.018200 | 0.125000 | 0.103000 | 0.120000 | 7.54e-01 | 8.08e-01 | 9.47e-02 | 1.66e-01 | 1.07e-01 |
| INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC | 184 | 5.92e-04 | 3.18e-03 | 0.2040 | -3.45e-02 | 0.037500 | 0.020500 | 0.196000 | -0.012200 | 4.20e-01 | 3.81e-01 | 6.32e-01 | 4.69e-06 | 7.75e-01 |
| SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | 62 | 3.35e-01 | 4.41e-01 | 0.2040 | 2.52e-02 | 0.107000 | -0.046700 | 0.098800 | -0.132000 | 7.32e-01 | 1.44e-01 | 5.25e-01 | 1.79e-01 | 7.28e-02 |
| RAF INDEPENDENT MAPK1 3 ACTIVATION | 20 | 7.97e-01 | 8.35e-01 | 0.2040 | 5.39e-02 | 0.034700 | 0.146000 | 0.079000 | 0.098700 | 6.76e-01 | 7.88e-01 | 2.58e-01 | 5.41e-01 | 4.45e-01 |
| METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS | 100 | 3.48e-02 | 8.40e-02 | 0.2030 | 1.41e-02 | 0.054900 | 0.069300 | 0.182000 | -0.008250 | 8.07e-01 | 3.43e-01 | 2.31e-01 | 1.63e-03 | 8.87e-01 |
| SHC1 EVENTS IN ERBB4 SIGNALING | 12 | 9.64e-01 | 9.69e-01 | 0.2030 | 4.41e-02 | 0.129000 | -0.071300 | 0.042800 | -0.126000 | 7.92e-01 | 4.39e-01 | 6.69e-01 | 7.97e-01 | 4.52e-01 |
| UB SPECIFIC PROCESSING PROTEASES | 164 | 1.82e-02 | 5.08e-02 | 0.2030 | 1.33e-02 | 0.162000 | -0.078000 | 0.054200 | -0.075700 | 7.70e-01 | 3.45e-04 | 8.50e-02 | 2.32e-01 | 9.47e-02 |
| SIGNALING BY HEDGEHOG | 141 | 1.15e-02 | 3.49e-02 | 0.2030 | 1.11e-01 | 0.088400 | -0.010300 | 0.136000 | 0.047200 | 2.28e-02 | 7.03e-02 | 8.33e-01 | 5.30e-03 | 3.34e-01 |
| COPII MEDIATED VESICLE TRANSPORT | 64 | 1.22e-01 | 2.16e-01 | 0.2020 | -5.10e-02 | 0.104000 | 0.044200 | 0.142000 | -0.074400 | 4.81e-01 | 1.51e-01 | 5.41e-01 | 4.99e-02 | 3.04e-01 |
| VESICLE MEDIATED TRANSPORT | 600 | 1.21e-12 | 4.26e-11 | 0.2020 | -6.06e-02 | 0.073300 | 0.014700 | 0.175000 | -0.033800 | 1.17e-02 | 2.27e-03 | 5.42e-01 | 3.59e-13 | 1.60e-01 |
| SIGNALING BY PTK6 | 49 | 2.87e-01 | 3.97e-01 | 0.2020 | 7.72e-02 | 0.151000 | 0.040800 | 0.097500 | 0.027000 | 3.50e-01 | 6.74e-02 | 6.21e-01 | 2.38e-01 | 7.44e-01 |
| SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS | 41 | 3.93e-01 | 4.91e-01 | 0.2020 | 4.71e-02 | 0.085600 | 0.111000 | 0.110000 | 0.082200 | 6.02e-01 | 3.43e-01 | 2.21e-01 | 2.23e-01 | 3.62e-01 |
| DISEASES OF METABOLISM | 193 | 8.32e-04 | 4.25e-03 | 0.2010 | 1.34e-01 | 0.060700 | 0.082300 | 0.064700 | 0.087300 | 1.30e-03 | 1.46e-01 | 4.90e-02 | 1.22e-01 | 3.69e-02 |
| RHO GTPASES ACTIVATE IQGAPS | 23 | 7.91e-01 | 8.31e-01 | 0.2000 | 1.04e-02 | 0.111000 | -0.033000 | 0.076900 | -0.144000 | 9.31e-01 | 3.58e-01 | 7.84e-01 | 5.23e-01 | 2.33e-01 |
| SIGNALLING TO ERKS | 32 | 5.87e-01 | 6.58e-01 | 0.2000 | -1.17e-01 | 0.037100 | 0.035300 | 0.150000 | -0.030000 | 2.51e-01 | 7.16e-01 | 7.30e-01 | 1.41e-01 | 7.69e-01 |
| TRANSCRIPTIONAL REGULATION BY E2F6 | 34 | 2.81e-01 | 3.91e-01 | 0.1980 | 8.52e-02 | -0.028000 | -0.008320 | 0.086100 | -0.154000 | 3.90e-01 | 7.77e-01 | 9.33e-01 | 3.85e-01 | 1.20e-01 |
| EPIGENETIC REGULATION OF GENE EXPRESSION | 102 | 2.64e-02 | 6.74e-02 | 0.1980 | 1.40e-01 | -0.054700 | 0.011300 | -0.128000 | 0.011400 | 1.50e-02 | 3.40e-01 | 8.43e-01 | 2.52e-02 | 8.43e-01 |
| CELL CYCLE MITOTIC | 467 | 4.07e-06 | 4.11e-05 | 0.1980 | -2.42e-02 | 0.066400 | -0.107000 | 0.071200 | -0.132000 | 3.72e-01 | 1.43e-02 | 7.61e-05 | 8.69e-03 | 1.03e-06 |
| RECYCLING PATHWAY OF L1 | 40 | 4.36e-01 | 5.30e-01 | 0.1970 | -4.69e-02 | 0.094700 | 0.053700 | 0.157000 | -0.017400 | 6.08e-01 | 3.00e-01 | 5.57e-01 | 8.60e-02 | 8.49e-01 |
| CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA | 59 | 1.80e-01 | 2.83e-01 | 0.1970 | 1.36e-01 | -0.067800 | 0.027700 | -0.122000 | 0.006000 | 7.07e-02 | 3.68e-01 | 7.13e-01 | 1.06e-01 | 9.36e-01 |
| MET PROMOTES CELL MOTILITY | 38 | 5.54e-01 | 6.29e-01 | 0.1970 | -1.70e-02 | 0.013400 | 0.120000 | 0.142000 | 0.060500 | 8.56e-01 | 8.86e-01 | 2.01e-01 | 1.30e-01 | 5.19e-01 |
| RAC3 GTPASE CYCLE | 88 | 1.03e-01 | 1.91e-01 | 0.1960 | 4.53e-02 | 0.058900 | 0.044500 | 0.166000 | 0.056500 | 4.63e-01 | 3.40e-01 | 4.71e-01 | 7.00e-03 | 3.60e-01 |
| P75NTR SIGNALS VIA NF KB | 16 | 8.01e-01 | 8.37e-01 | 0.1960 | 1.42e-01 | 0.082000 | 0.065200 | -0.068400 | 0.051800 | 3.27e-01 | 5.70e-01 | 6.52e-01 | 6.36e-01 | 7.20e-01 |
| REPRODUCTION | 73 | 8.81e-02 | 1.71e-01 | 0.1960 | -9.18e-02 | -0.064000 | -0.103000 | -0.123000 | -0.008100 | 1.75e-01 | 3.45e-01 | 1.28e-01 | 6.96e-02 | 9.05e-01 |
| ADAPTIVE IMMUNE SYSTEM | 582 | 6.07e-07 | 7.26e-06 | 0.1950 | 3.93e-02 | 0.130000 | -0.076500 | 0.084900 | -0.081900 | 1.07e-01 | 9.80e-08 | 1.70e-03 | 4.95e-04 | 7.79e-04 |
| MYD88 INDEPENDENT TLR4 CASCADE | 92 | 6.12e-02 | 1.29e-01 | 0.1950 | 1.13e-02 | 0.093600 | 0.036500 | 0.153000 | -0.067500 | 8.51e-01 | 1.21e-01 | 5.46e-01 | 1.12e-02 | 2.64e-01 |
| DUAL INCISION IN TC NER | 64 | 3.79e-01 | 4.79e-01 | 0.1950 | 5.21e-02 | 0.095800 | -0.090500 | -0.052600 | -0.124000 | 4.71e-01 | 1.85e-01 | 2.11e-01 | 4.67e-01 | 8.72e-02 |
| NONHOMOLOGOUS END JOINING NHEJ | 42 | 5.27e-01 | 6.13e-01 | 0.1950 | -9.06e-02 | -0.021400 | -0.067500 | -0.029900 | -0.155000 | 3.10e-01 | 8.10e-01 | 4.49e-01 | 7.38e-01 | 8.25e-02 |
| AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | 14 | 6.41e-01 | 7.03e-01 | 0.1950 | -4.97e-02 | 0.136000 | 0.098300 | -0.039700 | 0.075000 | 7.48e-01 | 3.77e-01 | 5.24e-01 | 7.97e-01 | 6.27e-01 |
| SIGNALING BY KIT IN DISEASE | 20 | 7.77e-01 | 8.19e-01 | 0.1950 | -6.91e-02 | 0.115000 | -0.083900 | 0.113000 | 0.004090 | 5.93e-01 | 3.73e-01 | 5.16e-01 | 3.81e-01 | 9.75e-01 |
| TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER | 77 | 2.63e-01 | 3.73e-01 | 0.1950 | 8.85e-03 | 0.104000 | -0.074500 | -0.001890 | -0.146000 | 8.93e-01 | 1.15e-01 | 2.59e-01 | 9.77e-01 | 2.67e-02 |
| TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES | 61 | 2.91e-01 | 4.01e-01 | 0.1940 | -6.94e-02 | -0.141000 | 0.043000 | -0.094500 | -0.048300 | 3.48e-01 | 5.71e-02 | 5.61e-01 | 2.02e-01 | 5.14e-01 |
| HIV LIFE CYCLE | 142 | 5.84e-02 | 1.26e-01 | 0.1940 | -7.49e-02 | 0.072500 | -0.083500 | 0.051500 | -0.131000 | 1.24e-01 | 1.36e-01 | 8.61e-02 | 2.90e-01 | 7.02e-03 |
| SIGNALING BY WNT | 261 | 2.75e-04 | 1.63e-03 | 0.1940 | 9.88e-02 | 0.151000 | -0.071100 | 0.003740 | 0.011200 | 6.10e-03 | 2.85e-05 | 4.85e-02 | 9.17e-01 | 7.55e-01 |
| DISEASES OF PROGRAMMED CELL DEATH | 53 | 3.92e-01 | 4.90e-01 | 0.1940 | 6.77e-02 | 0.060200 | -0.085300 | -0.128000 | -0.076400 | 3.94e-01 | 4.48e-01 | 2.83e-01 | 1.08e-01 | 3.36e-01 |
| RHOD GTPASE CYCLE | 50 | 3.00e-01 | 4.10e-01 | 0.1940 | -5.48e-02 | 0.013900 | 0.031000 | 0.172000 | 0.061900 | 5.03e-01 | 8.65e-01 | 7.05e-01 | 3.57e-02 | 4.49e-01 |
| HOMOLOGY DIRECTED REPAIR | 105 | 2.31e-02 | 6.09e-02 | 0.1940 | -5.09e-02 | -0.051400 | -0.038700 | -0.061200 | -0.164000 | 3.68e-01 | 3.64e-01 | 4.94e-01 | 2.79e-01 | 3.66e-03 |
| HCMV EARLY EVENTS | 78 | 2.54e-01 | 3.63e-01 | 0.1930 | -1.11e-01 | -0.086600 | 0.120000 | 0.052600 | 0.019600 | 8.98e-02 | 1.86e-01 | 6.82e-02 | 4.22e-01 | 7.65e-01 |
| TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS | 28 | 3.82e-01 | 4.82e-01 | 0.1920 | -6.32e-02 | 0.107000 | -0.022800 | -0.141000 | 0.029900 | 5.63e-01 | 3.26e-01 | 8.35e-01 | 1.98e-01 | 7.84e-01 |
| GOLGI TO ER RETROGRADE TRANSPORT | 118 | 2.55e-02 | 6.60e-02 | 0.1910 | -1.80e-02 | 0.023000 | 0.004730 | 0.186000 | -0.037000 | 7.35e-01 | 6.66e-01 | 9.29e-01 | 5.05e-04 | 4.88e-01 |
| POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE | 25 | 7.81e-01 | 8.21e-01 | 0.1890 | 1.40e-01 | 0.050400 | -0.051900 | 0.079800 | -0.067200 | 2.25e-01 | 6.63e-01 | 6.54e-01 | 4.90e-01 | 5.61e-01 |
| PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 237 | 5.39e-03 | 1.93e-02 | 0.1880 | 1.43e-02 | 0.082500 | -0.137000 | -0.063200 | -0.076400 | 7.05e-01 | 2.90e-02 | 2.98e-04 | 9.43e-02 | 4.33e-02 |
| SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP | 62 | 3.45e-01 | 4.49e-01 | 0.1880 | 1.23e-01 | 0.059500 | -0.072600 | -0.087100 | -0.060600 | 9.29e-02 | 4.18e-01 | 3.23e-01 | 2.36e-01 | 4.10e-01 |
| SIGNALING BY FLT3 ITD AND TKD MUTANTS | 15 | 6.86e-01 | 7.41e-01 | 0.1870 | -2.53e-02 | 0.066100 | -0.118000 | -0.056800 | 0.112000 | 8.65e-01 | 6.58e-01 | 4.27e-01 | 7.03e-01 | 4.53e-01 |
| MITOCHONDRIAL BIOGENESIS | 92 | 2.57e-02 | 6.62e-02 | 0.1860 | 7.69e-02 | 0.054300 | -0.022200 | -0.032400 | -0.156000 | 2.03e-01 | 3.69e-01 | 7.13e-01 | 5.92e-01 | 9.88e-03 |
| ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS | 17 | 7.51e-01 | 7.94e-01 | 0.1830 | 4.38e-02 | -0.089800 | -0.032700 | -0.037100 | -0.145000 | 7.55e-01 | 5.22e-01 | 8.16e-01 | 7.91e-01 | 3.00e-01 |
| TRANSCRIPTION OF THE HIV GENOME | 67 | 4.34e-01 | 5.28e-01 | 0.1830 | 1.86e-02 | 0.060400 | -0.088100 | -0.032500 | -0.144000 | 7.93e-01 | 3.93e-01 | 2.13e-01 | 6.46e-01 | 4.18e-02 |
| REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS | 12 | 8.86e-01 | 9.10e-01 | 0.1820 | -7.47e-02 | 0.105000 | 0.073500 | 0.079300 | 0.069600 | 6.54e-01 | 5.31e-01 | 6.60e-01 | 6.35e-01 | 6.76e-01 |
| SUMOYLATION OF TRANSCRIPTION COFACTORS | 42 | 4.48e-01 | 5.41e-01 | 0.1810 | -7.46e-03 | -0.047300 | 0.160000 | -0.057700 | 0.040400 | 9.33e-01 | 5.96e-01 | 7.26e-02 | 5.17e-01 | 6.51e-01 |
| MAP2K AND MAPK ACTIVATION | 36 | 6.37e-01 | 7.01e-01 | 0.1810 | 1.04e-01 | 0.055100 | 0.085100 | 0.007570 | 0.108000 | 2.78e-01 | 5.68e-01 | 3.77e-01 | 9.37e-01 | 2.63e-01 |
| DNA DAMAGE RECOGNITION IN GG NER | 38 | 5.79e-01 | 6.51e-01 | 0.1810 | -8.18e-02 | 0.127000 | -0.038200 | 0.040000 | -0.083300 | 3.83e-01 | 1.75e-01 | 6.84e-01 | 6.70e-01 | 3.75e-01 |
| P75NTR RECRUITS SIGNALLING COMPLEXES | 13 | 9.31e-01 | 9.44e-01 | 0.1810 | 1.35e-01 | 0.091200 | -0.000981 | -0.068000 | 0.039600 | 3.99e-01 | 5.69e-01 | 9.95e-01 | 6.71e-01 | 8.05e-01 |
| SIGNALING BY FGFR IN DISEASE | 54 | 3.10e-01 | 4.17e-01 | 0.1810 | -2.46e-02 | 0.153000 | -0.046400 | -0.016600 | -0.080300 | 7.55e-01 | 5.25e-02 | 5.55e-01 | 8.33e-01 | 3.07e-01 |
| FLT3 SIGNALING IN DISEASE | 27 | 4.44e-01 | 5.38e-01 | 0.1810 | 3.94e-02 | -0.006180 | -0.041300 | 0.018800 | 0.171000 | 7.23e-01 | 9.56e-01 | 7.10e-01 | 8.66e-01 | 1.25e-01 |
| DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE | 42 | 5.22e-01 | 6.09e-01 | 0.1800 | -1.12e-01 | -0.076400 | -0.080400 | -0.072000 | -0.049700 | 2.09e-01 | 3.92e-01 | 3.68e-01 | 4.19e-01 | 5.78e-01 |
| GENE SILENCING BY RNA | 79 | 2.99e-01 | 4.10e-01 | 0.1800 | -1.26e-01 | -0.073900 | 0.067100 | -0.080800 | 0.014500 | 5.36e-02 | 2.56e-01 | 3.03e-01 | 2.15e-01 | 8.24e-01 |
| CHEMOKINE RECEPTORS BIND CHEMOKINES | 14 | 8.12e-01 | 8.48e-01 | 0.1800 | -1.85e-02 | 0.005370 | -0.170000 | -0.054700 | 0.013600 | 9.04e-01 | 9.72e-01 | 2.71e-01 | 7.23e-01 | 9.30e-01 |
| INTRINSIC PATHWAY FOR APOPTOSIS | 50 | 5.96e-01 | 6.67e-01 | 0.1800 | -7.55e-02 | 0.087000 | -0.115000 | 0.015100 | -0.074700 | 3.56e-01 | 2.87e-01 | 1.59e-01 | 8.54e-01 | 3.61e-01 |
| HEMOSTASIS | 463 | 1.97e-09 | 4.47e-08 | 0.1800 | 1.04e-02 | 0.131000 | 0.016700 | 0.102000 | 0.066000 | 7.03e-01 | 1.54e-06 | 5.40e-01 | 1.79e-04 | 1.53e-02 |
| SIGNALING BY ERBB2 | 47 | 5.60e-01 | 6.33e-01 | 0.1790 | 2.96e-02 | 0.154000 | -0.029300 | 0.060100 | -0.056100 | 7.25e-01 | 6.82e-02 | 7.28e-01 | 4.76e-01 | 5.06e-01 |
| ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 280 | 5.71e-03 | 2.01e-02 | 0.1790 | -6.19e-03 | 0.091000 | -0.069500 | 0.066900 | -0.120000 | 8.59e-01 | 8.96e-03 | 4.60e-02 | 5.48e-02 | 5.58e-04 |
| SODIUM CALCIUM EXCHANGERS | 10 | 9.39e-01 | 9.49e-01 | 0.1790 | -8.00e-02 | 0.072500 | 0.093300 | 0.077700 | 0.074700 | 6.62e-01 | 6.91e-01 | 6.10e-01 | 6.71e-01 | 6.82e-01 |
| SEMAPHORIN INTERACTIONS | 64 | 6.23e-01 | 6.91e-01 | 0.1780 | -1.98e-02 | -0.067400 | 0.110000 | -0.051600 | 0.108000 | 7.85e-01 | 3.51e-01 | 1.27e-01 | 4.76e-01 | 1.35e-01 |
| ION CHANNEL TRANSPORT | 135 | 1.48e-01 | 2.46e-01 | 0.1770 | -3.99e-02 | -0.066100 | 0.130000 | 0.053700 | 0.075900 | 4.24e-01 | 1.85e-01 | 9.29e-03 | 2.82e-01 | 1.28e-01 |
| HIV TRANSCRIPTION ELONGATION | 42 | 5.27e-01 | 6.13e-01 | 0.1770 | 2.50e-02 | -0.004590 | -0.043000 | -0.147000 | -0.085500 | 7.79e-01 | 9.59e-01 | 6.30e-01 | 1.00e-01 | 3.38e-01 |
| ACYL CHAIN REMODELLING OF PS | 14 | 7.48e-01 | 7.93e-01 | 0.1770 | 8.36e-02 | -0.027300 | 0.127000 | 0.043400 | -0.075000 | 5.88e-01 | 8.60e-01 | 4.12e-01 | 7.79e-01 | 6.27e-01 |
| STRIATED MUSCLE CONTRACTION | 22 | 8.20e-01 | 8.54e-01 | 0.1760 | 9.95e-02 | -0.015000 | -0.107000 | -0.095400 | -0.018500 | 4.19e-01 | 9.03e-01 | 3.83e-01 | 4.39e-01 | 8.81e-01 |
| CELL CYCLE | 582 | 1.87e-06 | 2.03e-05 | 0.1760 | -1.74e-02 | 0.040200 | -0.101000 | 0.045300 | -0.129000 | 4.76e-01 | 9.95e-02 | 3.16e-05 | 6.31e-02 | 1.13e-07 |
| SIGNAL TRANSDUCTION BY L1 | 21 | 8.33e-01 | 8.66e-01 | 0.1760 | -5.11e-02 | 0.115000 | 0.017400 | 0.121000 | 0.005940 | 6.85e-01 | 3.60e-01 | 8.90e-01 | 3.36e-01 | 9.62e-01 |
| EPHA MEDIATED GROWTH CONE COLLAPSE | 27 | 7.17e-01 | 7.67e-01 | 0.1760 | 2.77e-02 | -0.052300 | -0.057400 | -0.138000 | 0.071300 | 8.03e-01 | 6.38e-01 | 6.05e-01 | 2.15e-01 | 5.22e-01 |
| NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | 40 | 3.92e-01 | 4.90e-01 | 0.1750 | 4.03e-02 | -0.092800 | 0.038000 | 0.130000 | 0.044000 | 6.59e-01 | 3.10e-01 | 6.78e-01 | 1.54e-01 | 6.30e-01 |
| LEISHMANIA INFECTION | 182 | 9.20e-04 | 4.62e-03 | 0.1750 | 5.71e-03 | 0.135000 | 0.012600 | 0.079800 | 0.076100 | 8.94e-01 | 1.72e-03 | 7.70e-01 | 6.37e-02 | 7.72e-02 |
| ENDOGENOUS STEROLS | 20 | 9.14e-01 | 9.32e-01 | 0.1750 | 1.43e-01 | 0.085500 | -0.044300 | -0.028700 | -0.002630 | 2.69e-01 | 5.08e-01 | 7.32e-01 | 8.24e-01 | 9.84e-01 |
| METABOLISM OF STEROIDS | 109 | 1.69e-01 | 2.69e-01 | 0.1740 | 4.86e-02 | 0.092200 | -0.049200 | 0.131000 | -0.005410 | 3.81e-01 | 9.66e-02 | 3.76e-01 | 1.83e-02 | 9.22e-01 |
| SIGNALING BY FGFR | 71 | 5.17e-01 | 6.04e-01 | 0.1740 | 9.97e-02 | 0.114000 | -0.064300 | 0.008130 | -0.055100 | 1.47e-01 | 9.76e-02 | 3.50e-01 | 9.06e-01 | 4.23e-01 |
| NICOTINATE METABOLISM | 24 | 5.50e-01 | 6.27e-01 | 0.1730 | -1.35e-03 | -0.052200 | 0.097700 | 0.069800 | -0.113000 | 9.91e-01 | 6.58e-01 | 4.08e-01 | 5.54e-01 | 3.36e-01 |
| ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | 23 | 7.31e-01 | 7.80e-01 | 0.1730 | -2.55e-02 | -0.025100 | 0.167000 | 0.022600 | 0.013600 | 8.32e-01 | 8.35e-01 | 1.65e-01 | 8.51e-01 | 9.10e-01 |
| TRANSPORT OF SMALL MOLECULES | 552 | 2.44e-08 | 3.83e-07 | 0.1720 | 3.56e-02 | 0.109000 | 0.007370 | 0.120000 | 0.044400 | 1.54e-01 | 1.27e-05 | 7.68e-01 | 1.52e-06 | 7.58e-02 |
| SIGNALING BY ACTIVIN | 12 | 9.61e-01 | 9.66e-01 | 0.1720 | -5.03e-02 | 0.033800 | 0.072900 | 0.138000 | 0.035800 | 7.63e-01 | 8.40e-01 | 6.62e-01 | 4.06e-01 | 8.30e-01 |
| CARGO CONCENTRATION IN THE ER | 30 | 6.44e-01 | 7.06e-01 | 0.1700 | -5.15e-02 | 0.095400 | 0.068300 | 0.111000 | -0.016800 | 6.26e-01 | 3.66e-01 | 5.17e-01 | 2.93e-01 | 8.73e-01 |
| SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 | 619 | 3.10e-10 | 8.98e-09 | 0.1700 | -4.56e-02 | 0.050700 | 0.080600 | 0.125000 | 0.046000 | 5.39e-02 | 3.23e-02 | 6.61e-04 | 1.16e-07 | 5.21e-02 |
| RNA POLYMERASE I TRANSCRIPTION INITIATION | 47 | 3.51e-01 | 4.55e-01 | 0.1700 | 1.60e-01 | -0.042500 | 0.031700 | -0.018100 | -0.014600 | 5.78e-02 | 6.15e-01 | 7.07e-01 | 8.30e-01 | 8.63e-01 |
| POST TRANSLATIONAL PROTEIN MODIFICATION | 1185 | 8.40e-15 | 3.36e-13 | 0.1700 | -2.92e-02 | 0.089300 | -0.021000 | 0.129000 | -0.053100 | 9.43e-02 | 3.04e-07 | 2.29e-01 | 1.09e-13 | 2.31e-03 |
| OXIDATIVE STRESS INDUCED SENESCENCE | 77 | 4.45e-01 | 5.39e-01 | 0.1690 | -1.76e-02 | -0.083300 | 0.092200 | -0.104000 | 0.046000 | 7.90e-01 | 2.07e-01 | 1.62e-01 | 1.14e-01 | 4.86e-01 |
| APOPTOTIC EXECUTION PHASE | 44 | 5.70e-01 | 6.43e-01 | 0.1690 | 2.24e-03 | 0.067000 | -0.152000 | 0.014400 | -0.028400 | 9.79e-01 | 4.42e-01 | 8.07e-02 | 8.69e-01 | 7.44e-01 |
| TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS | 54 | 5.03e-01 | 5.91e-01 | 0.1690 | -5.51e-02 | -0.083600 | 0.133000 | 0.026700 | 0.000539 | 4.84e-01 | 2.88e-01 | 9.01e-02 | 7.34e-01 | 9.95e-01 |
| SIGNALING BY TGFB FAMILY MEMBERS | 96 | 8.25e-02 | 1.63e-01 | 0.1690 | -1.22e-02 | 0.154000 | -0.018000 | 0.063400 | 0.018100 | 8.36e-01 | 9.19e-03 | 7.61e-01 | 2.83e-01 | 7.60e-01 |
| TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE | 92 | 1.17e-01 | 2.09e-01 | 0.1660 | -6.52e-02 | 0.086200 | 0.035000 | 0.104000 | -0.062700 | 2.80e-01 | 1.53e-01 | 5.62e-01 | 8.58e-02 | 2.99e-01 |
| APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | 33 | 5.98e-01 | 6.69e-01 | 0.1660 | 8.96e-02 | 0.043700 | -0.046200 | 0.069900 | 0.103000 | 3.73e-01 | 6.64e-01 | 6.46e-01 | 4.87e-01 | 3.06e-01 |
| TELOMERE C STRAND LAGGING STRAND SYNTHESIS | 33 | 8.46e-01 | 8.75e-01 | 0.1660 | 4.13e-02 | 0.038000 | -0.091000 | 0.053700 | -0.115000 | 6.82e-01 | 7.06e-01 | 3.66e-01 | 5.94e-01 | 2.54e-01 |
| RHO GTPASE EFFECTORS | 243 | 9.58e-03 | 3.03e-02 | 0.1650 | -1.30e-02 | 0.118000 | -0.031200 | 0.086300 | -0.069400 | 7.28e-01 | 1.58e-03 | 4.03e-01 | 2.07e-02 | 6.31e-02 |
| EPH EPHRIN MEDIATED REPULSION OF CELLS | 49 | 5.44e-01 | 6.24e-01 | 0.1640 | -9.50e-02 | 0.010100 | 0.101000 | 0.068100 | 0.054000 | 2.50e-01 | 9.03e-01 | 2.22e-01 | 4.09e-01 | 5.14e-01 |
| BASE EXCISION REPAIR | 55 | 5.50e-01 | 6.27e-01 | 0.1630 | 6.35e-04 | -0.019500 | -0.067500 | -0.139000 | -0.050100 | 9.94e-01 | 8.02e-01 | 3.87e-01 | 7.50e-02 | 5.21e-01 |
| SIGNALING BY SCF KIT | 41 | 6.88e-01 | 7.43e-01 | 0.1630 | 1.69e-02 | 0.004720 | 0.054700 | 0.134000 | 0.073200 | 8.52e-01 | 9.58e-01 | 5.45e-01 | 1.38e-01 | 4.17e-01 |
| ESTROGEN DEPENDENT GENE EXPRESSION | 99 | 1.47e-01 | 2.45e-01 | 0.1610 | 1.18e-02 | -0.002710 | -0.015500 | -0.153000 | 0.048100 | 8.40e-01 | 9.63e-01 | 7.90e-01 | 8.68e-03 | 4.09e-01 |
| NUCLEOTIDE EXCISION REPAIR | 109 | 1.78e-01 | 2.81e-01 | 0.1610 | 5.51e-03 | 0.093600 | -0.052100 | -0.025200 | -0.118000 | 9.21e-01 | 9.16e-02 | 3.48e-01 | 6.49e-01 | 3.37e-02 |
| NOD1 2 SIGNALING PATHWAY | 34 | 5.29e-01 | 6.14e-01 | 0.1600 | 1.13e-02 | 0.039100 | 0.128000 | 0.084900 | -0.015300 | 9.09e-01 | 6.93e-01 | 1.95e-01 | 3.92e-01 | 8.78e-01 |
| NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS | 51 | 4.68e-01 | 5.60e-01 | 0.1600 | 8.06e-02 | 0.123000 | 0.028800 | 0.050300 | -0.022600 | 3.20e-01 | 1.28e-01 | 7.22e-01 | 5.35e-01 | 7.80e-01 |
| MEIOSIS | 61 | 2.81e-01 | 3.91e-01 | 0.1580 | -8.09e-02 | -0.045300 | -0.110000 | -0.063900 | -0.013200 | 2.75e-01 | 5.41e-01 | 1.37e-01 | 3.88e-01 | 8.59e-01 |
| NUCLEOTIDE SALVAGE | 21 | 7.48e-01 | 7.93e-01 | 0.1580 | 1.08e-01 | -0.034500 | -0.047300 | 0.096000 | 0.027800 | 3.94e-01 | 7.84e-01 | 7.07e-01 | 4.46e-01 | 8.26e-01 |
| FLT3 SIGNALING | 36 | 4.55e-01 | 5.47e-01 | 0.1570 | -2.73e-02 | 0.001430 | -0.013100 | 0.049500 | 0.145000 | 7.77e-01 | 9.88e-01 | 8.92e-01 | 6.07e-01 | 1.31e-01 |
| MUSCLE CONTRACTION | 152 | 1.60e-02 | 4.59e-02 | 0.1560 | -1.19e-01 | 0.003910 | 0.072300 | -0.047400 | 0.053800 | 1.16e-02 | 9.34e-01 | 1.24e-01 | 3.14e-01 | 2.53e-01 |
| PTEN REGULATION | 132 | 3.07e-01 | 4.15e-01 | 0.1550 | 9.67e-02 | 0.084100 | -0.073600 | 0.000679 | -0.047300 | 5.54e-02 | 9.57e-02 | 1.45e-01 | 9.89e-01 | 3.49e-01 |
| PLATELET HOMEOSTASIS | 76 | 1.11e-01 | 2.02e-01 | 0.1550 | -4.06e-02 | 0.111000 | -0.041000 | 0.046300 | 0.079000 | 5.41e-01 | 9.46e-02 | 5.37e-01 | 4.85e-01 | 2.34e-01 |
| CELL JUNCTION ORGANIZATION | 71 | 3.15e-01 | 4.20e-01 | 0.1550 | -7.69e-02 | 0.075100 | 0.008920 | 0.108000 | 0.027000 | 2.63e-01 | 2.74e-01 | 8.97e-01 | 1.16e-01 | 6.95e-01 |
| SIGNALING BY TGF BETA RECEPTOR COMPLEX | 72 | 1.50e-01 | 2.48e-01 | 0.1540 | -4.31e-02 | 0.147000 | -0.011700 | 0.000324 | -0.014400 | 5.27e-01 | 3.09e-02 | 8.64e-01 | 9.96e-01 | 8.32e-01 |
| DNA DOUBLE STRAND BREAK REPAIR | 134 | 5.45e-02 | 1.20e-01 | 0.1530 | -5.91e-02 | -0.061700 | -0.008600 | -0.040800 | -0.120000 | 2.38e-01 | 2.18e-01 | 8.64e-01 | 4.15e-01 | 1.64e-02 |
| DUAL INCISION IN GG NER | 40 | 8.30e-01 | 8.63e-01 | 0.1520 | -2.30e-02 | 0.106000 | -0.076700 | -0.021100 | -0.071600 | 8.01e-01 | 2.48e-01 | 4.02e-01 | 8.17e-01 | 4.34e-01 |
| TRANSCRIPTIONAL REGULATION BY SMALL RNAS | 60 | 4.50e-01 | 5.43e-01 | 0.1520 | -1.06e-01 | -0.031000 | 0.087200 | -0.056800 | -0.001610 | 1.56e-01 | 6.78e-01 | 2.43e-01 | 4.47e-01 | 9.83e-01 |
| COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC | 85 | 2.78e-01 | 3.88e-01 | 0.1510 | 6.37e-03 | -0.021100 | 0.048200 | 0.142000 | 0.001210 | 9.19e-01 | 7.37e-01 | 4.42e-01 | 2.40e-02 | 9.85e-01 |
| EXTENSION OF TELOMERES | 49 | 4.89e-01 | 5.80e-01 | 0.1510 | 1.08e-01 | -0.019200 | -0.056700 | 0.008120 | -0.086700 | 1.92e-01 | 8.16e-01 | 4.93e-01 | 9.22e-01 | 2.94e-01 |
| CILIUM ASSEMBLY | 189 | 1.08e-02 | 3.33e-02 | 0.1510 | -5.19e-02 | -0.126000 | 0.039700 | 0.046000 | -0.017600 | 2.19e-01 | 2.78e-03 | 3.48e-01 | 2.77e-01 | 6.76e-01 |
| NEGATIVE REGULATION OF FLT3 | 14 | 9.51e-01 | 9.60e-01 | 0.1500 | 3.74e-02 | -0.114000 | 0.042200 | 0.041100 | 0.068200 | 8.08e-01 | 4.61e-01 | 7.84e-01 | 7.90e-01 | 6.59e-01 |
| GROWTH HORMONE RECEPTOR SIGNALING | 20 | 9.55e-01 | 9.62e-01 | 0.1490 | 2.45e-02 | -0.027200 | 0.063300 | 0.056100 | 0.116000 | 8.50e-01 | 8.33e-01 | 6.24e-01 | 6.64e-01 | 3.67e-01 |
| CYTOKINE SIGNALING IN IMMUNE SYSTEM | 525 | 3.81e-04 | 2.13e-03 | 0.1480 | 4.99e-02 | 0.113000 | -0.071200 | 0.039600 | -0.012900 | 5.14e-02 | 1.09e-05 | 5.47e-03 | 1.22e-01 | 6.14e-01 |
| SIGNALING BY NUCLEAR RECEPTORS | 214 | 1.48e-02 | 4.29e-02 | 0.1480 | 5.62e-02 | 0.121000 | -0.039300 | 0.023500 | 0.044000 | 1.57e-01 | 2.33e-03 | 3.22e-01 | 5.54e-01 | 2.68e-01 |
| FORMATION OF THE EARLY ELONGATION COMPLEX | 33 | 7.48e-01 | 7.93e-01 | 0.1480 | 6.65e-02 | 0.005970 | -0.024900 | -0.093700 | -0.088900 | 5.08e-01 | 9.53e-01 | 8.05e-01 | 3.52e-01 | 3.77e-01 |
| HCMV LATE EVENTS | 63 | 5.56e-01 | 6.30e-01 | 0.1470 | -9.78e-02 | 0.014300 | 0.018300 | 0.092000 | -0.055400 | 1.80e-01 | 8.44e-01 | 8.02e-01 | 2.07e-01 | 4.47e-01 |
| SENSORY PERCEPTION | 132 | 2.76e-02 | 7.00e-02 | 0.1470 | -7.41e-03 | 0.042100 | 0.006870 | -0.085800 | 0.111000 | 8.83e-01 | 4.04e-01 | 8.92e-01 | 8.91e-02 | 2.76e-02 |
| DEUBIQUITINATION | 237 | 3.60e-02 | 8.66e-02 | 0.1460 | -8.61e-03 | 0.115000 | -0.039800 | 0.043200 | -0.067000 | 8.20e-01 | 2.25e-03 | 2.92e-01 | 2.53e-01 | 7.61e-02 |
| DEADENYLATION DEPENDENT MRNA DECAY | 55 | 5.46e-01 | 6.25e-01 | 0.1460 | -4.55e-02 | -0.069600 | -0.043700 | -0.016300 | -0.110000 | 5.60e-01 | 3.72e-01 | 5.76e-01 | 8.34e-01 | 1.58e-01 |
| SIGNALING BY NOTCH | 187 | 4.73e-02 | 1.09e-01 | 0.1440 | 1.04e-01 | 0.053500 | 0.023500 | -0.026800 | 0.076900 | 1.46e-02 | 2.08e-01 | 5.81e-01 | 5.28e-01 | 7.01e-02 |
| INTERFERON GAMMA SIGNALING | 71 | 4.21e-01 | 5.18e-01 | 0.1440 | 6.84e-02 | 0.000605 | -0.077300 | -0.094900 | 0.032100 | 3.20e-01 | 9.93e-01 | 2.60e-01 | 1.67e-01 | 6.41e-01 |
| METABOLISM OF VITAMINS AND COFACTORS | 147 | 1.71e-01 | 2.72e-01 | 0.1440 | 5.35e-02 | 0.074400 | 0.021300 | 0.108000 | 0.011900 | 2.64e-01 | 1.20e-01 | 6.56e-01 | 2.38e-02 | 8.03e-01 |
| SURFACTANT METABOLISM | 16 | 9.00e-01 | 9.21e-01 | 0.1440 | 2.87e-02 | 0.132000 | 0.005010 | -0.035300 | 0.033000 | 8.43e-01 | 3.61e-01 | 9.72e-01 | 8.07e-01 | 8.19e-01 |
| NICOTINAMIDE SALVAGING | 15 | 9.56e-01 | 9.63e-01 | 0.1430 | -9.52e-02 | -0.064300 | -0.046800 | 0.038200 | -0.059300 | 5.23e-01 | 6.66e-01 | 7.54e-01 | 7.98e-01 | 6.91e-01 |
| VISUAL PHOTOTRANSDUCTION | 55 | 5.42e-01 | 6.23e-01 | 0.1430 | 5.91e-02 | 0.019500 | -0.014100 | -0.061200 | 0.112000 | 4.49e-01 | 8.02e-01 | 8.57e-01 | 4.33e-01 | 1.51e-01 |
| DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS | 358 | 1.12e-03 | 5.54e-03 | 0.1420 | 4.64e-02 | 0.094000 | 0.029100 | 0.088400 | 0.023400 | 1.33e-01 | 2.32e-03 | 3.46e-01 | 4.17e-03 | 4.49e-01 |
| TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | 43 | 4.95e-01 | 5.85e-01 | 0.1420 | -1.03e-01 | 0.069500 | 0.050200 | 0.014300 | 0.044500 | 2.42e-01 | 4.31e-01 | 5.69e-01 | 8.71e-01 | 6.14e-01 |
| RNA POLYMERASE II TRANSCRIBES SNRNA GENES | 74 | 4.85e-01 | 5.76e-01 | 0.1420 | -4.07e-02 | -0.051100 | -0.055300 | -0.043200 | -0.105000 | 5.45e-01 | 4.48e-01 | 4.11e-01 | 5.21e-01 | 1.20e-01 |
| EPH EPHRIN SIGNALING | 90 | 3.31e-01 | 4.36e-01 | 0.1420 | -1.54e-02 | 0.104000 | 0.015300 | 0.093300 | 0.008180 | 8.00e-01 | 8.88e-02 | 8.02e-01 | 1.26e-01 | 8.93e-01 |
| METABOLISM OF FOLATE AND PTERINES | 15 | 8.61e-01 | 8.88e-01 | 0.1410 | 6.21e-02 | 0.036900 | 0.074900 | 0.034800 | -0.087800 | 6.77e-01 | 8.05e-01 | 6.16e-01 | 8.16e-01 | 5.56e-01 |
| FANCONI ANEMIA PATHWAY | 36 | 7.98e-01 | 8.35e-01 | 0.1400 | -3.14e-02 | -0.111000 | 0.060000 | -0.033100 | -0.042400 | 7.45e-01 | 2.51e-01 | 5.33e-01 | 7.31e-01 | 6.60e-01 |
| ZINC TRANSPORTERS | 15 | 9.19e-01 | 9.36e-01 | 0.1400 | -3.41e-03 | 0.100000 | -0.059300 | 0.014400 | 0.077200 | 9.82e-01 | 5.02e-01 | 6.91e-01 | 9.23e-01 | 6.05e-01 |
| POLO LIKE KINASE MEDIATED EVENTS | 13 | 9.24e-01 | 9.40e-01 | 0.1390 | 8.80e-02 | 0.068200 | 0.037000 | -0.041600 | -0.061900 | 5.83e-01 | 6.70e-01 | 8.18e-01 | 7.95e-01 | 6.99e-01 |
| DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA | 63 | 6.48e-01 | 7.07e-01 | 0.1390 | 8.63e-02 | 0.085100 | -0.046200 | 0.013800 | 0.046600 | 2.36e-01 | 2.43e-01 | 5.27e-01 | 8.49e-01 | 5.22e-01 |
| INTRACELLULAR SIGNALING BY SECOND MESSENGERS | 274 | 5.99e-03 | 2.09e-02 | 0.1380 | -1.76e-02 | 0.081700 | 0.033400 | 0.103000 | -0.017500 | 6.17e-01 | 2.03e-02 | 3.42e-01 | 3.35e-03 | 6.18e-01 |
| SIGNALING BY RECEPTOR TYROSINE KINASES | 452 | 1.52e-05 | 1.37e-04 | 0.1370 | -3.56e-02 | 0.076200 | 0.053500 | 0.094000 | 0.007410 | 1.97e-01 | 5.69e-03 | 5.21e-02 | 6.42e-04 | 7.88e-01 |
| DOWNREGULATION OF ERBB2 SIGNALING | 27 | 7.45e-01 | 7.92e-01 | 0.1350 | -1.78e-03 | 0.125000 | 0.026100 | 0.004670 | -0.043500 | 9.87e-01 | 2.61e-01 | 8.14e-01 | 9.67e-01 | 6.96e-01 |
| GRB2 EVENTS IN ERBB2 SIGNALING | 14 | 9.87e-01 | 9.90e-01 | 0.1340 | 5.04e-02 | 0.050000 | -0.057200 | -0.035900 | -0.092100 | 7.44e-01 | 7.46e-01 | 7.11e-01 | 8.16e-01 | 5.51e-01 |
| SIGNALING BY ERBB2 IN CANCER | 24 | 9.15e-01 | 9.32e-01 | 0.1340 | 3.37e-03 | 0.130000 | -0.028100 | 0.017100 | -0.008480 | 9.77e-01 | 2.72e-01 | 8.12e-01 | 8.84e-01 | 9.43e-01 |
| MAPK FAMILY SIGNALING CASCADES | 281 | 2.96e-03 | 1.22e-02 | 0.1340 | 2.34e-02 | 0.107000 | 0.031400 | 0.068700 | -0.012800 | 5.00e-01 | 2.03e-03 | 3.66e-01 | 4.80e-02 | 7.12e-01 |
| TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES | 45 | 6.62e-01 | 7.18e-01 | 0.1340 | -5.05e-02 | -0.064200 | 0.065400 | 0.045900 | -0.069300 | 5.58e-01 | 4.56e-01 | 4.48e-01 | 5.94e-01 | 4.22e-01 |
| TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | 79 | 5.80e-01 | 6.52e-01 | 0.1300 | -1.05e-01 | -0.044800 | 0.055700 | 0.001060 | -0.030600 | 1.08e-01 | 4.91e-01 | 3.93e-01 | 9.87e-01 | 6.39e-01 |
| OTHER INTERLEUKIN SIGNALING | 19 | 9.43e-01 | 9.53e-01 | 0.1280 | 2.06e-02 | -0.002650 | 0.008220 | -0.011000 | 0.126000 | 8.77e-01 | 9.84e-01 | 9.51e-01 | 9.34e-01 | 3.42e-01 |
| RESOLUTION OF ABASIC SITES AP SITES | 37 | 9.04e-01 | 9.25e-01 | 0.1280 | -3.79e-02 | -0.027100 | -0.066600 | -0.076800 | -0.062200 | 6.90e-01 | 7.75e-01 | 4.84e-01 | 4.19e-01 | 5.13e-01 |
| NERVOUS SYSTEM DEVELOPMENT | 541 | 6.22e-06 | 6.01e-05 | 0.1280 | 5.51e-02 | 0.085400 | -0.022800 | -0.047700 | 0.056100 | 2.91e-02 | 7.16e-04 | 3.67e-01 | 5.88e-02 | 2.64e-02 |
| CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY | 22 | 8.42e-01 | 8.72e-01 | 0.1260 | -8.31e-02 | 0.050300 | -0.044800 | 0.005590 | 0.066500 | 5.00e-01 | 6.83e-01 | 7.16e-01 | 9.64e-01 | 5.90e-01 |
| DEVELOPMENTAL BIOLOGY | 792 | 3.96e-09 | 7.66e-08 | 0.1260 | 4.61e-02 | 0.064100 | 0.021400 | -0.050400 | 0.081600 | 2.87e-02 | 2.34e-03 | 3.10e-01 | 1.66e-02 | 1.05e-04 |
| DNA REPAIR | 288 | 7.32e-03 | 2.44e-02 | 0.1260 | -4.49e-02 | -0.072700 | -0.000445 | -0.035700 | -0.085500 | 1.91e-01 | 3.43e-02 | 9.90e-01 | 2.99e-01 | 1.28e-02 |
| PI3K EVENTS IN ERBB2 SIGNALING | 14 | 9.79e-01 | 9.83e-01 | 0.1250 | -6.79e-02 | 0.035200 | 0.062600 | 0.075600 | 0.014900 | 6.60e-01 | 8.19e-01 | 6.85e-01 | 6.24e-01 | 9.23e-01 |
| OVARIAN TUMOR DOMAIN PROTEASES | 36 | 7.43e-01 | 7.91e-01 | 0.1250 | -1.99e-02 | 0.114000 | -0.009050 | 0.013500 | 0.043200 | 8.36e-01 | 2.35e-01 | 9.25e-01 | 8.88e-01 | 6.54e-01 |
| ESR MEDIATED SIGNALING | 160 | 1.73e-01 | 2.74e-01 | 0.1240 | 4.20e-02 | 0.106000 | -0.042400 | -0.020000 | 0.015600 | 3.60e-01 | 2.13e-02 | 3.55e-01 | 6.64e-01 | 7.34e-01 |
| REGULATION OF TP53 ACTIVITY | 148 | 2.37e-01 | 3.47e-01 | 0.1210 | -6.63e-02 | -0.039700 | 0.054900 | 0.066700 | -0.035800 | 1.65e-01 | 4.05e-01 | 2.49e-01 | 1.62e-01 | 4.53e-01 |
| SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | 31 | 8.82e-01 | 9.06e-01 | 0.1200 | 1.92e-02 | 0.062300 | 0.043200 | 0.004520 | 0.090900 | 8.53e-01 | 5.49e-01 | 6.77e-01 | 9.65e-01 | 3.81e-01 |
| TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES | 35 | 7.78e-01 | 8.19e-01 | 0.1180 | -5.22e-03 | 0.006330 | 0.009940 | -0.051600 | -0.106000 | 9.57e-01 | 9.48e-01 | 9.19e-01 | 5.98e-01 | 2.79e-01 |
| REGULATION OF PTEN GENE TRANSCRIPTION | 57 | 8.65e-01 | 8.91e-01 | 0.1140 | -5.81e-02 | -0.058800 | 0.064900 | 0.045100 | -0.001240 | 4.49e-01 | 4.43e-01 | 3.97e-01 | 5.56e-01 | 9.87e-01 |
| PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE | 19 | 9.32e-01 | 9.44e-01 | 0.1130 | 2.17e-02 | -0.045800 | -0.065200 | 0.055200 | -0.054700 | 8.70e-01 | 7.30e-01 | 6.23e-01 | 6.77e-01 | 6.80e-01 |
| POTENTIAL THERAPEUTICS FOR SARS | 76 | 4.26e-01 | 5.23e-01 | 0.1130 | -5.44e-03 | 0.091300 | -0.017500 | -0.009520 | 0.063300 | 9.35e-01 | 1.69e-01 | 7.92e-01 | 8.86e-01 | 3.40e-01 |
| HCMV INFECTION | 101 | 5.31e-01 | 6.15e-01 | 0.1130 | -4.11e-02 | -0.020500 | 0.034700 | 0.091900 | -0.031700 | 4.76e-01 | 7.23e-01 | 5.47e-01 | 1.11e-01 | 5.82e-01 |
| SHC1 EVENTS IN ERBB2 SIGNALING | 20 | 9.66e-01 | 9.71e-01 | 0.1120 | 6.36e-02 | 0.018100 | 0.034200 | 0.076500 | -0.033200 | 6.22e-01 | 8.89e-01 | 7.91e-01 | 5.54e-01 | 7.97e-01 |
| TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS | 28 | 9.52e-01 | 9.60e-01 | 0.1080 | 2.28e-02 | 0.075300 | 0.034500 | 0.065800 | -0.001240 | 8.35e-01 | 4.91e-01 | 7.52e-01 | 5.47e-01 | 9.91e-01 |
| SUMOYLATION | 158 | 4.65e-01 | 5.57e-01 | 0.1020 | -9.00e-02 | -0.014100 | 0.033200 | 0.030900 | 0.003630 | 5.11e-02 | 7.60e-01 | 4.72e-01 | 5.04e-01 | 9.37e-01 |
| CELLULAR SENESCENCE | 140 | 7.94e-01 | 8.33e-01 | 0.1010 | -3.16e-02 | -0.069300 | 0.056000 | -0.018800 | 0.029300 | 5.19e-01 | 1.57e-01 | 2.53e-01 | 7.01e-01 | 5.50e-01 |
| FORMATION OF RNA POL II ELONGATION COMPLEX | 57 | 8.95e-01 | 9.18e-01 | 0.0989 | 2.59e-02 | -0.017300 | -0.024800 | -0.086800 | -0.026000 | 7.35e-01 | 8.21e-01 | 7.47e-01 | 2.57e-01 | 7.35e-01 |
| MEIOTIC SYNAPSIS | 38 | 9.29e-01 | 9.43e-01 | 0.0988 | -6.54e-02 | -0.029200 | -0.012800 | -0.050600 | 0.043800 | 4.86e-01 | 7.55e-01 | 8.92e-01 | 5.90e-01 | 6.41e-01 |
| ORGANELLE BIOGENESIS AND MAINTENANCE | 281 | 2.58e-02 | 6.64e-02 | 0.0974 | -9.63e-03 | -0.067500 | 0.019500 | 0.020400 | -0.063500 | 7.82e-01 | 5.21e-02 | 5.75e-01 | 5.58e-01 | 6.75e-02 |
| P38MAPK EVENTS | 12 | 9.98e-01 | 9.98e-01 | 0.0967 | -6.46e-02 | -0.052200 | 0.022900 | 0.009920 | 0.042800 | 6.99e-01 | 7.54e-01 | 8.91e-01 | 9.53e-01 | 7.97e-01 |
| TRANSCRIPTIONAL REGULATION BY TP53 | 338 | 1.28e-01 | 2.23e-01 | 0.0922 | -3.27e-02 | -0.001450 | -0.020800 | -0.021600 | -0.080800 | 3.03e-01 | 9.64e-01 | 5.12e-01 | 4.96e-01 | 1.09e-02 |
| RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION | 23 | 9.92e-01 | 9.93e-01 | 0.0904 | 2.36e-02 | -0.011600 | 0.029200 | 0.009710 | 0.080900 | 8.44e-01 | 9.23e-01 | 8.09e-01 | 9.36e-01 | 5.02e-01 |
| AGGREPHAGY | 34 | 9.91e-01 | 9.93e-01 | 0.0867 | -7.54e-03 | 0.016400 | -0.066000 | -0.019900 | -0.049500 | 9.39e-01 | 8.69e-01 | 5.06e-01 | 8.41e-01 | 6.18e-01 |
| RNA POLYMERASE II TRANSCRIPTION | 1070 | 3.47e-03 | 1.37e-02 | 0.0847 | -2.37e-02 | -0.002510 | -0.038600 | -0.035600 | -0.062100 | 1.95e-01 | 8.91e-01 | 3.46e-02 | 5.17e-02 | 6.83e-04 |
| HSF1 DEPENDENT TRANSACTIVATION | 33 | 9.27e-01 | 9.41e-01 | 0.0769 | 3.54e-02 | 0.026800 | 0.035800 | -0.007530 | -0.051000 | 7.25e-01 | 7.90e-01 | 7.22e-01 | 9.40e-01 | 6.12e-01 |
| DNA DOUBLE STRAND BREAK RESPONSE | 51 | 9.36e-01 | 9.47e-01 | 0.0715 | -2.95e-02 | 0.035400 | -0.026300 | 0.036400 | 0.031200 | 7.16e-01 | 6.62e-01 | 7.46e-01 | 6.53e-01 | 7.00e-01 |
| INTERFERON SIGNALING | 158 | 5.39e-01 | 6.22e-01 | 0.0639 | -3.78e-02 | -0.009900 | -0.046500 | -0.004000 | 0.019300 | 4.13e-01 | 8.30e-01 | 3.13e-01 | 9.31e-01 | 6.75e-01 |
Detailed Gene set reports
EUKARYOTIC TRANSLATION ELONGATION
| metric | value |
|---|---|
| setSize | 87 |
| pMANOVA | 2.18e-55 |
| p.adjustMANOVA | 1.27e-52 |
| s.dist | 1.13 |
| s.hyp | 0.759 |
| s.amy | 0.506 |
| s.hip | -0.568 |
| s.pag | -0.342 |
| s.ni | -0.00591 |
| p.hyp | 1.61e-34 |
| p.amy | 3.15e-16 |
| p.hip | 5.18e-20 |
| p.pag | 3.61e-08 |
| p.ni | 0.924 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Rpl27a | 6827 | -7289 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Rps3a1 | 6917 | -6741 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Rps6 | 6941 | -6279 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
| Rpl9 | 6697 | -6266 |
| Eef1b2 | 6448 | -6301 |
| Rpl5 | 5400 | -7518 |
| Rps23 | 6623 | -6052 |
| Rps4x | 6042 | -6597 |
| Rps14 | 6673 | -5672 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Eef1a1 | 5841 | 6783 | -5328 | 5851 | 3479 |
| Eef1a2 | -4541 | 6507 | -920 | 6158 | 482 |
| Eef1b2 | 6448 | 5196 | -6301 | 898 | -3560 |
| Eef1d | 6612 | 3276 | -1430 | -1602 | 2645 |
| Eef1g | 5280 | 7188 | -7133 | -2018 | -2269 |
| Eef2 | 4311 | 5018 | -692 | 5850 | 6536 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
| metric | value |
|---|---|
| setSize | 106 |
| pMANOVA | 1.5e-53 |
| p.adjustMANOVA | 5.81e-51 |
| s.dist | 1.02 |
| s.hyp | 0.679 |
| s.amy | 0.482 |
| s.hip | -0.536 |
| s.pag | -0.252 |
| s.ni | -0.0297 |
| p.hyp | 1.19e-33 |
| p.amy | 9.62e-18 |
| p.hip | 1.41e-21 |
| p.pag | 7.51e-06 |
| p.ni | 0.597 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Rpl27a | 6827 | -7289 |
| Ssr3 | 7258 | -6804 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Sec61g | 7493 | -6250 |
| Rps3a1 | 6917 | -6741 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Spcs1 | 7108 | -6132 |
| Rps6 | 6941 | -6279 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
| Rpl9 | 6697 | -6266 |
| Rpl5 | 5400 | -7518 |
| Rps23 | 6623 | -6052 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ddost | 2688 | 5850 | 178 | -222 | 6349 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rpn1 | 3181 | 2470 | -3846 | 5558 | 205 |
| Rpn2 | 5171 | 3111 | -226 | 1699 | 5261 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Sec11a | 2809 | 776 | -5915 | 4139 | 3309 |
| Sec11c | 5061 | 6539 | -4786 | -1444 | -4511 |
| Sec61a1 | 471 | -5145 | 6810 | -1055 | 6419 |
| Sec61a2 | -5126 | -5801 | 1624 | 2244 | 2521 |
| Sec61b | 7049 | 1997 | -2692 | -267 | 3838 |
| Sec61g | 7493 | 3077 | -6250 | 1215 | -3192 |
| Spcs1 | 7108 | 7675 | -6132 | -1456 | -3634 |
| Spcs2 | 4593 | 5233 | -7758 | -940 | -1234 |
| Spcs3 | -950 | 5786 | -7224 | 8019 | -4665 |
| Srp14 | 2490 | 3653 | -6223 | -2174 | -1928 |
| Srp19 | 5501 | 3921 | -7093 | -2045 | -5225 |
| Srp54a | 2370 | 6776 | -7360 | -583 | -3682 |
| Srp68 | 146 | -924 | 5591 | 8778 | 5105 |
| Srp72 | -1718 | 6980 | -2498 | 1964 | 18 |
| Srp9 | 3900 | 5401 | -5596 | 1838 | -5694 |
| Srpr | 57 | 6313 | 2479 | 7734 | -275 |
| Srprb | -3531 | 5220 | 123 | 4085 | 5974 |
| Ssr1 | -1008 | 4809 | -6662 | 3819 | -2277 |
| Ssr2 | 4502 | 3864 | -2249 | 4457 | -1371 |
| Ssr3 | 7258 | 7300 | -6804 | 7907 | -4378 |
| Ssr4 | 6055 | -77 | -2472 | -2165 | 869 |
| Tram1 | 6285 | 2413 | -2959 | 6418 | -2138 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
| metric | value |
|---|---|
| setSize | 94 |
| pMANOVA | 2.62e-48 |
| p.adjustMANOVA | 6.08e-46 |
| s.dist | 1.02 |
| s.hyp | 0.658 |
| s.amy | 0.459 |
| s.hip | -0.53 |
| s.pag | -0.341 |
| s.ni | -0.0378 |
| p.hyp | 2.5e-28 |
| p.amy | 1.41e-14 |
| p.hip | 6.09e-19 |
| p.pag | 1.17e-08 |
| p.ni | 0.526 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Rpl27a | 6827 | -7289 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Rps3a1 | 6917 | -6741 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Rps6 | 6941 | -6279 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
| Rpl9 | 6697 | -6266 |
| Rpl5 | 5400 | -7518 |
| Rps23 | 6623 | -6052 |
| Rps4x | 6042 | -6597 |
| Rps14 | 6673 | -5672 |
| Rps13 | 6657 | -5583 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Asns | -5965 | 7217 | -5876 | 7416 | -5779 |
| Atf2 | -5851 | 1618 | -5007 | 8379 | -4104 |
| Atf3 | 1402 | -1068 | -969 | -5186 | 420 |
| Atf4 | -499 | -1984 | -321 | -2853 | -5478 |
| Cebpb | -2662 | 4309 | 6343 | 544 | 51 |
| Cebpg | -920 | 613 | -7265 | 647 | -4600 |
| Ddit3 | 3796 | 4066 | 191 | -6362 | 6968 |
| Eif2ak4 | -6880 | -7902 | 7760 | -429 | 5233 |
| Eif2s1 | -2003 | 7090 | -7556 | 8513 | -7288 |
| Eif2s2 | 3573 | 7098 | -7798 | -5067 | -5729 |
| Eif2s3x | 3602 | 7035 | -6154 | 5580 | -3406 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Gcn1 | 1817 | -7285 | 7949 | -4593 | 8244 |
| Impact | 2196 | 5310 | -5797 | -2551 | 2158 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
COMPLEX I BIOGENESIS
| metric | value |
|---|---|
| setSize | 56 |
| pMANOVA | 6.5e-25 |
| p.adjustMANOVA | 4.43e-23 |
| s.dist | 1.02 |
| s.hyp | 0.524 |
| s.amy | 0.529 |
| s.hip | -0.49 |
| s.pag | -0.322 |
| s.ni | -0.364 |
| p.hyp | 1.16e-11 |
| p.amy | 7.71e-12 |
| p.hip | 2.29e-10 |
| p.pag | 3.03e-05 |
| p.ni | 2.48e-06 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hyp |
|---|---|---|
| mt-Nd3 | 7407 | 7337 |
| mt-Nd6 | 7403 | 6944 |
| mt-Nd5 | 7227 | 6492 |
| mt-Nd4 | 7499 | 6181 |
| mt-Nd2 | 7154 | 6171 |
| Timmdc1 | 7075 | 6226 |
| Ndufaf1 | 6859 | 6359 |
| mt-Nd1 | 7301 | 5713 |
| Ndufc1 | 7587 | 5478 |
| Ndufb9 | 6479 | 6089 |
| Ndufb11 | 6212 | 6180 |
| Ndufs3 | 5747 | 6664 |
| Ndufaf5 | 5437 | 6834 |
| Ndufaf6 | 6328 | 5592 |
| Ndufb4 | 6289 | 5445 |
| Ndufb5 | 7652 | 4385 |
| Ndufb8 | 5931 | 5591 |
| Ndufa5 | 6830 | 4781 |
| Ndufa13 | 5596 | 4994 |
| Ndufab1 | 5374 | 5137 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acad9 | -223 | 1892 | 1303 | 8381 | -2268 |
| Ecsit | 5803 | 2232 | 5019 | -1685 | -732 |
| mt-Nd1 | 5713 | 7301 | -7258 | -2320 | -4384 |
| mt-Nd2 | 6171 | 7154 | -7176 | -1627 | -4323 |
| mt-Nd3 | 7337 | 7407 | -7691 | -6837 | 4148 |
| mt-Nd4 | 6181 | 7499 | -6839 | -1057 | -3590 |
| mt-Nd5 | 6492 | 7227 | -6216 | 322 | -1727 |
| mt-Nd6 | 6944 | 7403 | -6543 | -3132 | -5121 |
| Ndufa1 | 6747 | 2682 | -2157 | -6310 | -902 |
| Ndufa10 | -2896 | 7194 | -7175 | -8 | -6007 |
| Ndufa11 | 4790 | -871 | 691 | -2899 | -4199 |
| Ndufa12 | 3410 | 7277 | -5424 | -6559 | 746 |
| Ndufa13 | 4994 | 5596 | -100 | -5971 | 3048 |
| Ndufa2 | 7370 | -1281 | 108 | -3655 | 175 |
| Ndufa3 | 5608 | -178 | 3142 | -6518 | 2193 |
| Ndufa5 | 4781 | 6830 | -5303 | -6063 | -2583 |
| Ndufa6 | 5333 | 4557 | -3639 | -3895 | -669 |
| Ndufa7 | 5517 | 4326 | -848 | -4990 | 617 |
| Ndufa8 | 3070 | 1617 | -5815 | -3232 | -821 |
| Ndufa9 | 822 | -1091 | -5785 | 788 | -3694 |
| Ndufab1 | 5137 | 5374 | -1496 | -5016 | -5345 |
| Ndufaf1 | 6359 | 6859 | -7003 | 5348 | -6792 |
| Ndufaf2 | 1248 | 5932 | -7514 | -5943 | -5310 |
| Ndufaf3 | 4088 | -1081 | -921 | -2257 | 1465 |
| Ndufaf4 | -1870 | 7583 | -7294 | 5308 | -7177 |
| Ndufaf5 | 6834 | 5437 | -6666 | 3093 | -6428 |
| Ndufaf6 | 5592 | 6328 | -4055 | 6157 | -5058 |
| Ndufaf7 | 6165 | -1131 | -2436 | 3533 | 3755 |
| Ndufb1 | 6049 | 3262 | -1698 | -1494 | 262 |
| Ndufb10 | 6235 | 295 | 87 | -1803 | -4744 |
| Ndufb11 | 6180 | 6212 | -4331 | -1647 | -4316 |
| Ndufb2 | 7123 | 1176 | -4654 | -3514 | -3366 |
| Ndufb3 | 1907 | 2377 | -5581 | -2620 | -3148 |
| Ndufb4 | 5445 | 6289 | -7102 | -1954 | -1675 |
| Ndufb5 | 4385 | 7652 | -6546 | -596 | -5663 |
| Ndufb6 | 4453 | 3990 | -6274 | -853 | -4948 |
| Ndufb7 | 4612 | 1304 | -626 | -4763 | 476 |
| Ndufb8 | 5591 | 5931 | -4210 | 862 | -3292 |
| Ndufb9 | 6089 | 6479 | -5428 | -3371 | -2916 |
| Ndufc1 | 5478 | 7587 | -6002 | -6112 | -2866 |
| Ndufc2 | 5494 | 4597 | -7659 | 2151 | -5165 |
| Ndufs1 | -3679 | 6120 | -4473 | 7932 | -5114 |
| Ndufs2 | 3514 | 7229 | -5625 | 403 | -291 |
| Ndufs3 | 6664 | 5747 | -3258 | -3881 | -4640 |
| Ndufs4 | 3311 | 7230 | -7264 | -2562 | -5432 |
| Ndufs5 | 5008 | 4499 | -4848 | -3718 | -3992 |
| Ndufs6 | 5789 | 3656 | -4610 | -5995 | 876 |
| Ndufs7 | 3848 | 2004 | 2701 | -5625 | 490 |
| Ndufs8 | 2818 | 330 | -3398 | 275 | -5753 |
| Ndufv1 | 6126 | 3309 | -2255 | -132 | -1730 |
| Ndufv2 | 2238 | 7605 | -7699 | -248 | -6974 |
| Ndufv3 | 2869 | 189 | 1197 | -6383 | 478 |
| Nubpl | 3656 | 22 | -5922 | -2803 | -3789 |
| Timmdc1 | 6226 | 7075 | -1523 | 4742 | 115 |
| Tmem126b | -1106 | 3081 | -4186 | 1886 | -2207 |
| Tmem186 | -6615 | -6828 | 5066 | -23 | 6133 |
EUKARYOTIC TRANSLATION INITIATION
| metric | value |
|---|---|
| setSize | 114 |
| pMANOVA | 1.1e-51 |
| p.adjustMANOVA | 3.18e-49 |
| s.dist | 0.987 |
| s.hyp | 0.632 |
| s.amy | 0.466 |
| s.hip | -0.544 |
| s.pag | -0.232 |
| s.ni | -0.0824 |
| p.hyp | 1.68e-31 |
| p.amy | 8.59e-18 |
| p.hip | 1.05e-23 |
| p.pag | 1.85e-05 |
| p.ni | 0.129 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Eif3j2 | 7061 | -7680 |
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Rpl27a | 6827 | -7289 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Rps3a1 | 6917 | -6741 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Rps6 | 6941 | -6279 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Eif3m | 5667 | -7481 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
| Rpl9 | 6697 | -6266 |
| Eif3e | 5337 | -7676 |
| Rpl5 | 5400 | -7518 |
| Rps23 | 6623 | -6052 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Eif1ax | -4858 | 3565 | -6218 | 8683 | -7134 |
| Eif2b1 | -5292 | -2030 | 2328 | 5382 | -4101 |
| Eif2b2 | 1073 | 4300 | 6340 | 2198 | 7043 |
| Eif2b3 | 418 | -1265 | -6346 | -1028 | -5688 |
| Eif2b4 | 5390 | 2862 | 1930 | -4306 | -3768 |
| Eif2b5 | 6016 | 3165 | -2373 | 2009 | -172 |
| Eif2s1 | -2003 | 7090 | -7556 | 8513 | -7288 |
| Eif2s2 | 3573 | 7098 | -7798 | -5067 | -5729 |
| Eif2s3x | 3602 | 7035 | -6154 | 5580 | -3406 |
| Eif3a | -5464 | -4405 | -5546 | -5480 | 7635 |
| Eif3b | 6718 | 1649 | 2789 | -781 | 5675 |
| Eif3c | 379 | 2604 | -2495 | 4506 | 2925 |
| Eif3d | 5186 | 133 | -2159 | -111 | -1035 |
| Eif3e | 5337 | 6630 | -7676 | 5701 | -6208 |
| Eif3f | 7577 | 5502 | -1607 | 232 | 1095 |
| Eif3g | 1910 | 4006 | -4890 | -1946 | -1789 |
| Eif3h | 3906 | 5135 | -6622 | 6092 | -5021 |
| Eif3i | 5030 | 2167 | 259 | 584 | -3995 |
| Eif3j1 | 447 | 327 | -3801 | 1562 | -3312 |
| Eif3j2 | 7061 | 7040 | -7680 | 1109 | -6230 |
| Eif3k | 4693 | -1060 | -2241 | -2251 | 122 |
| Eif3l | 6166 | 3556 | 2180 | 2515 | -2101 |
| Eif3m | 5667 | 6557 | -7481 | 6973 | -6900 |
| Eif4a1 | 7213 | 2118 | -3860 | 8473 | -2900 |
| Eif4a2 | -1907 | 5567 | -7748 | 8454 | -7228 |
| Eif4b | -2518 | 4027 | -5312 | 7202 | 3030 |
| Eif4e | 3459 | 6422 | -7631 | 5585 | -5425 |
| Eif4ebp1 | 4191 | 3036 | -3085 | 6170 | 2111 |
| Eif4g1 | -2092 | -6035 | 3639 | 39 | 6314 |
| Eif4h | -20 | -1019 | 1450 | 1660 | 6194 |
| Eif5 | -3504 | 4695 | -7687 | -4318 | -7378 |
| Eif5b | 922 | 5210 | -7771 | -6787 | 3979 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Pabpc1 | 5165 | 6207 | -6818 | -150 | 1038 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
| metric | value |
|---|---|
| setSize | 18 |
| pMANOVA | 7.33e-07 |
| p.adjustMANOVA | 8.59e-06 |
| s.dist | 0.959 |
| s.hyp | 0.545 |
| s.amy | 0.476 |
| s.hip | -0.419 |
| s.pag | -0.266 |
| s.ni | -0.388 |
| p.hyp | 6.34e-05 |
| p.amy | 0.000474 |
| p.hip | 0.0021 |
| p.pag | 0.0507 |
| p.ni | 0.00438 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | amy |
|---|---|---|
| mt-Atp8 | 7480 | 6132 |
| mt-Atp6 | 5939 | 6269 |
| Atp5h | 5830 | 5801 |
| Atp5a1 | 3259 | 7567 |
| Atp5c1 | 3289 | 7306 |
| Atp5g3 | 5588 | 4000 |
| Atp5b | 2580 | 7634 |
| Atp5j | 3593 | 3599 |
| Atp5l | 6034 | 1630 |
| Atp5e | 6876 | 1262 |
| Atp5d | 4949 | 1682 |
| Atp5pb | 768 | 6938 |
| Dmac2l | 1829 | 2673 |
| Atp5j2 | 3630 | 1314 |
| Atp5g1 | 3139 | 1013 |
| Atp5k | 6670 | 340 |
| Atp5o | 89 | 3792 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Atp5a1 | 3259 | 7567 | -5773 | 6434 | -3165 |
| Atp5b | 2580 | 7634 | -6205 | 5297 | -4923 |
| Atp5c1 | 3289 | 7306 | -7104 | 6710 | -7264 |
| Atp5d | 4949 | 1682 | 1455 | -4840 | -1505 |
| Atp5e | 6876 | 1262 | -3047 | -6025 | 971 |
| Atp5g1 | 3139 | 1013 | 4289 | 1068 | 361 |
| Atp5g2 | 7811 | -2849 | 6005 | -4684 | 731 |
| Atp5g3 | 5588 | 4000 | -5342 | -1122 | -3369 |
| Atp5h | 5830 | 5801 | -6889 | -3993 | -4997 |
| Atp5j | 3593 | 3599 | -5767 | -2771 | -1274 |
| Atp5j2 | 3630 | 1314 | -3474 | -3387 | -2120 |
| Atp5k | 6670 | 340 | 5008 | -6472 | 2070 |
| Atp5l | 6034 | 1630 | -5464 | 364 | -5543 |
| Atp5o | 89 | 3792 | -4472 | -1017 | -5634 |
| Atp5pb | 768 | 6938 | -7330 | 3305 | -7063 |
| Dmac2l | 1829 | 2673 | -6905 | -2688 | -7271 |
| mt-Atp6 | 5939 | 6269 | -6899 | -2601 | -4258 |
| mt-Atp8 | 7480 | 6132 | -19 | -4236 | 7576 |
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
| metric | value |
|---|---|
| setSize | 59 |
| pMANOVA | 3.5e-22 |
| p.adjustMANOVA | 2.03e-20 |
| s.dist | 0.946 |
| s.hyp | 0.588 |
| s.amy | 0.472 |
| s.hip | -0.548 |
| s.pag | -0.101 |
| s.ni | -0.13 |
| p.hyp | 5.3e-15 |
| p.amy | 3.69e-10 |
| p.hip | 3.4e-13 |
| p.pag | 0.179 |
| p.ni | 0.0838 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Eif3j2 | 7061 | -7680 |
| Rps24 | 6708 | -7078 |
| Rps3a1 | 6917 | -6741 |
| Rps6 | 6941 | -6279 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Eif3m | 5667 | -7481 |
| Rps8 | 6896 | -6090 |
| Eif3e | 5337 | -7676 |
| Rps23 | 6623 | -6052 |
| Rps4x | 6042 | -6597 |
| Rps14 | 6673 | -5672 |
| Rps13 | 6657 | -5583 |
| Rps27l | 6485 | -5513 |
| Pabpc1 | 5165 | -6818 |
| Rps20 | 7419 | -4679 |
| Rps9 | 7029 | -4931 |
| Rps18 | 4183 | -7830 |
| Rps19 | 7296 | -4361 |
| Rps16 | 6661 | -4770 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Eif1ax | -4858 | 3565 | -6218 | 8683 | -7134 |
| Eif2s1 | -2003 | 7090 | -7556 | 8513 | -7288 |
| Eif2s2 | 3573 | 7098 | -7798 | -5067 | -5729 |
| Eif2s3x | 3602 | 7035 | -6154 | 5580 | -3406 |
| Eif3a | -5464 | -4405 | -5546 | -5480 | 7635 |
| Eif3b | 6718 | 1649 | 2789 | -781 | 5675 |
| Eif3c | 379 | 2604 | -2495 | 4506 | 2925 |
| Eif3d | 5186 | 133 | -2159 | -111 | -1035 |
| Eif3e | 5337 | 6630 | -7676 | 5701 | -6208 |
| Eif3f | 7577 | 5502 | -1607 | 232 | 1095 |
| Eif3g | 1910 | 4006 | -4890 | -1946 | -1789 |
| Eif3h | 3906 | 5135 | -6622 | 6092 | -5021 |
| Eif3i | 5030 | 2167 | 259 | 584 | -3995 |
| Eif3j1 | 447 | 327 | -3801 | 1562 | -3312 |
| Eif3j2 | 7061 | 7040 | -7680 | 1109 | -6230 |
| Eif3k | 4693 | -1060 | -2241 | -2251 | 122 |
| Eif3l | 6166 | 3556 | 2180 | 2515 | -2101 |
| Eif3m | 5667 | 6557 | -7481 | 6973 | -6900 |
| Eif4a1 | 7213 | 2118 | -3860 | 8473 | -2900 |
| Eif4a2 | -1907 | 5567 | -7748 | 8454 | -7228 |
| Eif4b | -2518 | 4027 | -5312 | 7202 | 3030 |
| Eif4e | 3459 | 6422 | -7631 | 5585 | -5425 |
| Eif4ebp1 | 4191 | 3036 | -3085 | 6170 | 2111 |
| Eif4g1 | -2092 | -6035 | 3639 | 39 | 6314 |
| Eif4h | -20 | -1019 | 1450 | 1660 | 6194 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Pabpc1 | 5165 | 6207 | -6818 | -150 | 1038 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
RESPIRATORY ELECTRON TRANSPORT
| metric | value |
|---|---|
| setSize | 102 |
| pMANOVA | 2.82e-39 |
| p.adjustMANOVA | 3.14e-37 |
| s.dist | 0.944 |
| s.hyp | 0.463 |
| s.amy | 0.504 |
| s.hip | -0.453 |
| s.pag | -0.271 |
| s.ni | -0.378 |
| p.hyp | 6.25e-16 |
| p.amy | 1.31e-18 |
| p.hip | 2.63e-15 |
| p.pag | 2.28e-06 |
| p.ni | 4.5e-11 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hyp |
|---|---|---|
| mt-Nd3 | 7407 | 7337 |
| mt-Nd6 | 7403 | 6944 |
| mt-Co1 | 7585 | 6248 |
| mt-Nd5 | 7227 | 6492 |
| mt-Nd4 | 7499 | 6181 |
| mt-Nd2 | 7154 | 6171 |
| Timmdc1 | 7075 | 6226 |
| Ndufaf1 | 6859 | 6359 |
| Surf1 | 6722 | 6477 |
| Cox7a2l | 7474 | 5822 |
| Coq10b | 7725 | 5602 |
| Cox6a1 | 6256 | 6831 |
| mt-Nd1 | 7301 | 5713 |
| Ndufc1 | 7587 | 5478 |
| mt-Co2 | 7208 | 5704 |
| mt-Cytb | 7124 | 5767 |
| Ndufb9 | 6479 | 6089 |
| Ndufb11 | 6212 | 6180 |
| Ndufs3 | 5747 | 6664 |
| mt-Co3 | 6999 | 5441 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acad9 | -223 | 1892 | 1303 | 8381 | -2268 |
| Coq10a | 1571 | 5130 | 519 | -5431 | -3676 |
| Coq10b | 5602 | 7725 | -6240 | 7945 | -5653 |
| Cox11 | 1247 | -6664 | 1029 | 4408 | -817 |
| Cox14 | 1992 | -2141 | -2254 | -6080 | -3801 |
| Cox16 | 5115 | 4512 | -5735 | -650 | -6476 |
| Cox18 | 2726 | 3991 | 5549 | 8672 | 1514 |
| Cox19 | -963 | -4171 | -1598 | -3117 | 1112 |
| Cox20 | 4823 | 5088 | -7140 | -5870 | -922 |
| Cox4i1 | 5752 | 396 | -3641 | -2516 | -1900 |
| Cox5a | 4851 | 6815 | -3955 | -1299 | -5292 |
| Cox5b | 5594 | 5054 | 476 | -6692 | 1155 |
| Cox6a1 | 6831 | 6256 | -938 | -4503 | -2165 |
| Cox6b1 | 5128 | 1661 | -1189 | -4984 | -3965 |
| Cox6c | 4661 | 4697 | -5262 | -3482 | -905 |
| Cox7a2l | 5822 | 7474 | -6861 | -2784 | -2169 |
| Cox7b | 2531 | 4315 | -6488 | -4310 | -5044 |
| Cox7c | 4839 | 5580 | -3904 | -4569 | -1844 |
| Cox8a | 5257 | 4348 | 625 | -4317 | 2677 |
| Cyc1 | 5208 | 2214 | 695 | 4719 | -4024 |
| Cycs | 1049 | 7058 | -7801 | -4513 | -7336 |
| Ecsit | 5803 | 2232 | 5019 | -1685 | -732 |
| Etfa | 3333 | 2979 | -6847 | 5560 | -5752 |
| Etfb | 5300 | 1903 | -4960 | -4885 | 845 |
| Etfdh | -4233 | 1052 | -4448 | 7841 | -4439 |
| Lrpprc | -5902 | -6510 | -1170 | 5618 | -2059 |
| mt-Co1 | 6248 | 7585 | -7593 | 1521 | -2151 |
| mt-Co2 | 5704 | 7208 | -6777 | 710 | -7000 |
| mt-Co3 | 5441 | 6999 | -6525 | -442 | -4781 |
| mt-Cytb | 5767 | 7124 | -6683 | -491 | -3194 |
| mt-Nd1 | 5713 | 7301 | -7258 | -2320 | -4384 |
| mt-Nd2 | 6171 | 7154 | -7176 | -1627 | -4323 |
| mt-Nd3 | 7337 | 7407 | -7691 | -6837 | 4148 |
| mt-Nd4 | 6181 | 7499 | -6839 | -1057 | -3590 |
| mt-Nd5 | 6492 | 7227 | -6216 | 322 | -1727 |
| mt-Nd6 | 6944 | 7403 | -6543 | -3132 | -5121 |
| Ndufa1 | 6747 | 2682 | -2157 | -6310 | -902 |
| Ndufa10 | -2896 | 7194 | -7175 | -8 | -6007 |
| Ndufa11 | 4790 | -871 | 691 | -2899 | -4199 |
| Ndufa12 | 3410 | 7277 | -5424 | -6559 | 746 |
| Ndufa13 | 4994 | 5596 | -100 | -5971 | 3048 |
| Ndufa2 | 7370 | -1281 | 108 | -3655 | 175 |
| Ndufa3 | 5608 | -178 | 3142 | -6518 | 2193 |
| Ndufa4 | 4002 | 6647 | -6247 | -3408 | -3885 |
| Ndufa5 | 4781 | 6830 | -5303 | -6063 | -2583 |
| Ndufa6 | 5333 | 4557 | -3639 | -3895 | -669 |
| Ndufa7 | 5517 | 4326 | -848 | -4990 | 617 |
| Ndufa8 | 3070 | 1617 | -5815 | -3232 | -821 |
| Ndufa9 | 822 | -1091 | -5785 | 788 | -3694 |
| Ndufab1 | 5137 | 5374 | -1496 | -5016 | -5345 |
| Ndufaf1 | 6359 | 6859 | -7003 | 5348 | -6792 |
| Ndufaf2 | 1248 | 5932 | -7514 | -5943 | -5310 |
| Ndufaf3 | 4088 | -1081 | -921 | -2257 | 1465 |
| Ndufaf4 | -1870 | 7583 | -7294 | 5308 | -7177 |
| Ndufaf5 | 6834 | 5437 | -6666 | 3093 | -6428 |
| Ndufaf6 | 5592 | 6328 | -4055 | 6157 | -5058 |
| Ndufaf7 | 6165 | -1131 | -2436 | 3533 | 3755 |
| Ndufb1 | 6049 | 3262 | -1698 | -1494 | 262 |
| Ndufb10 | 6235 | 295 | 87 | -1803 | -4744 |
| Ndufb11 | 6180 | 6212 | -4331 | -1647 | -4316 |
| Ndufb2 | 7123 | 1176 | -4654 | -3514 | -3366 |
| Ndufb3 | 1907 | 2377 | -5581 | -2620 | -3148 |
| Ndufb4 | 5445 | 6289 | -7102 | -1954 | -1675 |
| Ndufb5 | 4385 | 7652 | -6546 | -596 | -5663 |
| Ndufb6 | 4453 | 3990 | -6274 | -853 | -4948 |
| Ndufb7 | 4612 | 1304 | -626 | -4763 | 476 |
| Ndufb8 | 5591 | 5931 | -4210 | 862 | -3292 |
| Ndufb9 | 6089 | 6479 | -5428 | -3371 | -2916 |
| Ndufc1 | 5478 | 7587 | -6002 | -6112 | -2866 |
| Ndufc2 | 5494 | 4597 | -7659 | 2151 | -5165 |
| Ndufs1 | -3679 | 6120 | -4473 | 7932 | -5114 |
| Ndufs2 | 3514 | 7229 | -5625 | 403 | -291 |
| Ndufs3 | 6664 | 5747 | -3258 | -3881 | -4640 |
| Ndufs4 | 3311 | 7230 | -7264 | -2562 | -5432 |
| Ndufs5 | 5008 | 4499 | -4848 | -3718 | -3992 |
| Ndufs6 | 5789 | 3656 | -4610 | -5995 | 876 |
| Ndufs7 | 3848 | 2004 | 2701 | -5625 | 490 |
| Ndufs8 | 2818 | 330 | -3398 | 275 | -5753 |
| Ndufv1 | 6126 | 3309 | -2255 | -132 | -1730 |
| Ndufv2 | 2238 | 7605 | -7699 | -248 | -6974 |
| Ndufv3 | 2869 | 189 | 1197 | -6383 | 478 |
| Nubpl | 3656 | 22 | -5922 | -2803 | -3789 |
| Sco1 | -5380 | 82 | -6608 | -5698 | -5592 |
| Sco2 | -1097 | 5749 | -3040 | -4639 | -34 |
| Sdha | -4231 | 4989 | -3687 | 6522 | 1446 |
| Sdhb | 2636 | 4256 | -3152 | 1532 | -5561 |
| Sdhc | 4351 | 7450 | -5449 | 1259 | -1330 |
| Sdhd | 2383 | 4784 | -4479 | 4685 | -2482 |
| Surf1 | 6477 | 6722 | -4189 | 10 | -2818 |
| Taco1 | 3660 | 4751 | 5594 | 5249 | -2134 |
| Timmdc1 | 6226 | 7075 | -1523 | 4742 | 115 |
| Tmem126b | -1106 | 3081 | -4186 | 1886 | -2207 |
| Tmem186 | -6615 | -6828 | 5066 | -23 | 6133 |
| Trap1 | 2487 | -260 | 6069 | 6860 | -807 |
| Uqcr10 | 5291 | 895 | -572 | -5539 | 919 |
| Uqcr11 | 5354 | -835 | 945 | -5641 | 931 |
| Uqcrb | 2763 | 7013 | -5636 | -6221 | -3359 |
| Uqcrc1 | 3404 | 782 | 1788 | 127 | -1968 |
| Uqcrc2 | -1038 | 5252 | -7454 | 8035 | -6299 |
| Uqcrfs1 | 1307 | 3712 | -825 | -1154 | -5658 |
| Uqcrh | 5525 | 3144 | -4076 | -3417 | -3580 |
| Uqcrq | 5570 | 4200 | -2706 | -5670 | -40 |
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00115 |
| p.adjustMANOVA | 0.00567 |
| s.dist | 0.941 |
| s.hyp | -0.628 |
| s.amy | -0.311 |
| s.hip | 0.445 |
| s.pag | 0.0986 |
| s.ni | 0.432 |
| p.hyp | 0.000585 |
| p.amy | 0.0886 |
| p.hip | 0.0148 |
| p.pag | 0.589 |
| p.ni | 0.0181 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Slit1 | -6537 | 7872 |
| Slit3 | -6843 | 6543 |
| Nell2 | -7041 | 4906 |
| Src | -4246 | 7491 |
| Robo3 | -5608 | 2988 |
| Ntn1 | -4584 | 2848 |
| Robo1 | -2990 | 3969 |
| Robo2 | -4859 | 1732 |
| Dcc | -1683 | 1938 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Dcc | -1683 | -4182 | 1938 | -2669 | 7266 |
| Nell2 | -7041 | -3071 | 4906 | 7290 | 3772 |
| Ntn1 | -4584 | 6164 | 2848 | -3793 | 6433 |
| Robo1 | -2990 | 1523 | 3969 | 1415 | 3468 |
| Robo2 | -4859 | 1007 | 1732 | -138 | -1215 |
| Robo3 | -5608 | -5609 | 2988 | -2413 | 4150 |
| Slit1 | -6537 | -6659 | 7872 | 3768 | 6633 |
| Slit2 | -4398 | -6570 | -4048 | 4732 | 4862 |
| Slit3 | -6843 | -2818 | 6543 | 3887 | -3635 |
| Src | -4246 | -5388 | 7491 | 5320 | 7262 |
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
| metric | value |
|---|---|
| setSize | 11 |
| pMANOVA | 0.00327 |
| p.adjustMANOVA | 0.0131 |
| s.dist | 0.935 |
| s.hyp | 0.0864 |
| s.amy | 0.647 |
| s.hip | -0.457 |
| s.pag | 0.025 |
| s.ni | -0.489 |
| p.hyp | 0.62 |
| p.amy | 0.000202 |
| p.hip | 0.00862 |
| p.pag | 0.886 |
| p.ni | 0.00502 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | ni |
|---|---|---|
| Lgmn | 7633 | -5731 |
| Hsp90b1 | 6059 | -5637 |
| Tlr3 | 4440 | -7420 |
| Ctss | 7659 | -4089 |
| Tlr7 | 6821 | -3630 |
| Ctsk | 4194 | -5896 |
| Ctsb | 7552 | -2018 |
| Ctsl | 5239 | -1918 |
| Unc93b1 | 5516 | -1228 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Cnpy3 | -4479 | 1570 | 1690 | -1962 | 2785 |
| Ctsb | 1591 | 7552 | -6048 | 4256 | -2018 |
| Ctsk | 5098 | 4194 | -1349 | -1583 | -5896 |
| Ctsl | 4600 | 5239 | -7444 | 4306 | -1918 |
| Ctss | 2751 | 7659 | -7423 | 5242 | -4089 |
| Hsp90b1 | -1002 | 6059 | -7799 | -1708 | -5637 |
| Lgmn | 4685 | 7633 | -5353 | 6981 | -5731 |
| Tlr3 | -1483 | 4440 | -7707 | 4920 | -7420 |
| Tlr7 | 923 | 6821 | -1779 | -3082 | -3630 |
| Tlr9 | -7083 | -1352 | 2149 | 512 | -2525 |
| Unc93b1 | 2986 | 5516 | 2274 | -5156 | -1228 |
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
| metric | value |
|---|---|
| setSize | 125 |
| pMANOVA | 2.47e-45 |
| p.adjustMANOVA | 4.77e-43 |
| s.dist | 0.916 |
| s.hyp | 0.466 |
| s.amy | 0.497 |
| s.hip | -0.433 |
| s.pag | -0.241 |
| s.ni | -0.359 |
| p.hyp | 2.19e-19 |
| p.amy | 7.83e-22 |
| p.hip | 5.89e-17 |
| p.pag | 3.19e-06 |
| p.ni | 4.44e-12 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hyp |
|---|---|---|
| mt-Nd3 | 7407 | 7337 |
| mt-Nd6 | 7403 | 6944 |
| Slc25a14 | 6546 | 7413 |
| mt-Co1 | 7585 | 6248 |
| mt-Nd5 | 7227 | 6492 |
| mt-Nd4 | 7499 | 6181 |
| mt-Atp8 | 6132 | 7480 |
| Ucp2 | 6438 | 7104 |
| mt-Nd2 | 7154 | 6171 |
| Timmdc1 | 7075 | 6226 |
| Ndufaf1 | 6859 | 6359 |
| Surf1 | 6722 | 6477 |
| Cox7a2l | 7474 | 5822 |
| Coq10b | 7725 | 5602 |
| Cox6a1 | 6256 | 6831 |
| mt-Nd1 | 7301 | 5713 |
| Ndufc1 | 7587 | 5478 |
| mt-Co2 | 7208 | 5704 |
| mt-Cytb | 7124 | 5767 |
| Ndufb9 | 6479 | 6089 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acad9 | -223 | 1892 | 1303 | 8381 | -2268 |
| Atp5a1 | 3259 | 7567 | -5773 | 6434 | -3165 |
| Atp5b | 2580 | 7634 | -6205 | 5297 | -4923 |
| Atp5c1 | 3289 | 7306 | -7104 | 6710 | -7264 |
| Atp5d | 4949 | 1682 | 1455 | -4840 | -1505 |
| Atp5e | 6876 | 1262 | -3047 | -6025 | 971 |
| Atp5g1 | 3139 | 1013 | 4289 | 1068 | 361 |
| Atp5g2 | 7811 | -2849 | 6005 | -4684 | 731 |
| Atp5g3 | 5588 | 4000 | -5342 | -1122 | -3369 |
| Atp5h | 5830 | 5801 | -6889 | -3993 | -4997 |
| Atp5j | 3593 | 3599 | -5767 | -2771 | -1274 |
| Atp5j2 | 3630 | 1314 | -3474 | -3387 | -2120 |
| Atp5k | 6670 | 340 | 5008 | -6472 | 2070 |
| Atp5l | 6034 | 1630 | -5464 | 364 | -5543 |
| Atp5o | 89 | 3792 | -4472 | -1017 | -5634 |
| Atp5pb | 768 | 6938 | -7330 | 3305 | -7063 |
| Coq10a | 1571 | 5130 | 519 | -5431 | -3676 |
| Coq10b | 5602 | 7725 | -6240 | 7945 | -5653 |
| Cox11 | 1247 | -6664 | 1029 | 4408 | -817 |
| Cox14 | 1992 | -2141 | -2254 | -6080 | -3801 |
| Cox16 | 5115 | 4512 | -5735 | -650 | -6476 |
| Cox18 | 2726 | 3991 | 5549 | 8672 | 1514 |
| Cox19 | -963 | -4171 | -1598 | -3117 | 1112 |
| Cox20 | 4823 | 5088 | -7140 | -5870 | -922 |
| Cox4i1 | 5752 | 396 | -3641 | -2516 | -1900 |
| Cox5a | 4851 | 6815 | -3955 | -1299 | -5292 |
| Cox5b | 5594 | 5054 | 476 | -6692 | 1155 |
| Cox6a1 | 6831 | 6256 | -938 | -4503 | -2165 |
| Cox6b1 | 5128 | 1661 | -1189 | -4984 | -3965 |
| Cox6c | 4661 | 4697 | -5262 | -3482 | -905 |
| Cox7a2l | 5822 | 7474 | -6861 | -2784 | -2169 |
| Cox7b | 2531 | 4315 | -6488 | -4310 | -5044 |
| Cox7c | 4839 | 5580 | -3904 | -4569 | -1844 |
| Cox8a | 5257 | 4348 | 625 | -4317 | 2677 |
| Cyc1 | 5208 | 2214 | 695 | 4719 | -4024 |
| Cycs | 1049 | 7058 | -7801 | -4513 | -7336 |
| Dmac2l | 1829 | 2673 | -6905 | -2688 | -7271 |
| Ecsit | 5803 | 2232 | 5019 | -1685 | -732 |
| Etfa | 3333 | 2979 | -6847 | 5560 | -5752 |
| Etfb | 5300 | 1903 | -4960 | -4885 | 845 |
| Etfdh | -4233 | 1052 | -4448 | 7841 | -4439 |
| Lrpprc | -5902 | -6510 | -1170 | 5618 | -2059 |
| mt-Atp6 | 5939 | 6269 | -6899 | -2601 | -4258 |
| mt-Atp8 | 7480 | 6132 | -19 | -4236 | 7576 |
| mt-Co1 | 6248 | 7585 | -7593 | 1521 | -2151 |
| mt-Co2 | 5704 | 7208 | -6777 | 710 | -7000 |
| mt-Co3 | 5441 | 6999 | -6525 | -442 | -4781 |
| mt-Cytb | 5767 | 7124 | -6683 | -491 | -3194 |
| mt-Nd1 | 5713 | 7301 | -7258 | -2320 | -4384 |
| mt-Nd2 | 6171 | 7154 | -7176 | -1627 | -4323 |
| mt-Nd3 | 7337 | 7407 | -7691 | -6837 | 4148 |
| mt-Nd4 | 6181 | 7499 | -6839 | -1057 | -3590 |
| mt-Nd5 | 6492 | 7227 | -6216 | 322 | -1727 |
| mt-Nd6 | 6944 | 7403 | -6543 | -3132 | -5121 |
| Ndufa1 | 6747 | 2682 | -2157 | -6310 | -902 |
| Ndufa10 | -2896 | 7194 | -7175 | -8 | -6007 |
| Ndufa11 | 4790 | -871 | 691 | -2899 | -4199 |
| Ndufa12 | 3410 | 7277 | -5424 | -6559 | 746 |
| Ndufa13 | 4994 | 5596 | -100 | -5971 | 3048 |
| Ndufa2 | 7370 | -1281 | 108 | -3655 | 175 |
| Ndufa3 | 5608 | -178 | 3142 | -6518 | 2193 |
| Ndufa4 | 4002 | 6647 | -6247 | -3408 | -3885 |
| Ndufa5 | 4781 | 6830 | -5303 | -6063 | -2583 |
| Ndufa6 | 5333 | 4557 | -3639 | -3895 | -669 |
| Ndufa7 | 5517 | 4326 | -848 | -4990 | 617 |
| Ndufa8 | 3070 | 1617 | -5815 | -3232 | -821 |
| Ndufa9 | 822 | -1091 | -5785 | 788 | -3694 |
| Ndufab1 | 5137 | 5374 | -1496 | -5016 | -5345 |
| Ndufaf1 | 6359 | 6859 | -7003 | 5348 | -6792 |
| Ndufaf2 | 1248 | 5932 | -7514 | -5943 | -5310 |
| Ndufaf3 | 4088 | -1081 | -921 | -2257 | 1465 |
| Ndufaf4 | -1870 | 7583 | -7294 | 5308 | -7177 |
| Ndufaf5 | 6834 | 5437 | -6666 | 3093 | -6428 |
| Ndufaf6 | 5592 | 6328 | -4055 | 6157 | -5058 |
| Ndufaf7 | 6165 | -1131 | -2436 | 3533 | 3755 |
| Ndufb1 | 6049 | 3262 | -1698 | -1494 | 262 |
| Ndufb10 | 6235 | 295 | 87 | -1803 | -4744 |
| Ndufb11 | 6180 | 6212 | -4331 | -1647 | -4316 |
| Ndufb2 | 7123 | 1176 | -4654 | -3514 | -3366 |
| Ndufb3 | 1907 | 2377 | -5581 | -2620 | -3148 |
| Ndufb4 | 5445 | 6289 | -7102 | -1954 | -1675 |
| Ndufb5 | 4385 | 7652 | -6546 | -596 | -5663 |
| Ndufb6 | 4453 | 3990 | -6274 | -853 | -4948 |
| Ndufb7 | 4612 | 1304 | -626 | -4763 | 476 |
| Ndufb8 | 5591 | 5931 | -4210 | 862 | -3292 |
| Ndufb9 | 6089 | 6479 | -5428 | -3371 | -2916 |
| Ndufc1 | 5478 | 7587 | -6002 | -6112 | -2866 |
| Ndufc2 | 5494 | 4597 | -7659 | 2151 | -5165 |
| Ndufs1 | -3679 | 6120 | -4473 | 7932 | -5114 |
| Ndufs2 | 3514 | 7229 | -5625 | 403 | -291 |
| Ndufs3 | 6664 | 5747 | -3258 | -3881 | -4640 |
| Ndufs4 | 3311 | 7230 | -7264 | -2562 | -5432 |
| Ndufs5 | 5008 | 4499 | -4848 | -3718 | -3992 |
| Ndufs6 | 5789 | 3656 | -4610 | -5995 | 876 |
| Ndufs7 | 3848 | 2004 | 2701 | -5625 | 490 |
| Ndufs8 | 2818 | 330 | -3398 | 275 | -5753 |
| Ndufv1 | 6126 | 3309 | -2255 | -132 | -1730 |
| Ndufv2 | 2238 | 7605 | -7699 | -248 | -6974 |
| Ndufv3 | 2869 | 189 | 1197 | -6383 | 478 |
| Nubpl | 3656 | 22 | -5922 | -2803 | -3789 |
| Pm20d1 | 6709 | 4547 | -1801 | 8437 | 2251 |
| Sco1 | -5380 | 82 | -6608 | -5698 | -5592 |
| Sco2 | -1097 | 5749 | -3040 | -4639 | -34 |
| Sdha | -4231 | 4989 | -3687 | 6522 | 1446 |
| Sdhb | 2636 | 4256 | -3152 | 1532 | -5561 |
| Sdhc | 4351 | 7450 | -5449 | 1259 | -1330 |
| Sdhd | 2383 | 4784 | -4479 | 4685 | -2482 |
| Slc25a14 | 7413 | 6546 | -6517 | 1916 | 917 |
| Slc25a27 | -6852 | -6154 | 6731 | 2552 | 1526 |
| Surf1 | 6477 | 6722 | -4189 | 10 | -2818 |
| Taco1 | 3660 | 4751 | 5594 | 5249 | -2134 |
| Timmdc1 | 6226 | 7075 | -1523 | 4742 | 115 |
| Tmem126b | -1106 | 3081 | -4186 | 1886 | -2207 |
| Tmem186 | -6615 | -6828 | 5066 | -23 | 6133 |
| Trap1 | 2487 | -260 | 6069 | 6860 | -807 |
| Ucp2 | 7104 | 6438 | 6890 | 4528 | 8022 |
| Ucp3 | -5308 | 3825 | -7171 | 5651 | -4310 |
| Uqcr10 | 5291 | 895 | -572 | -5539 | 919 |
| Uqcr11 | 5354 | -835 | 945 | -5641 | 931 |
| Uqcrb | 2763 | 7013 | -5636 | -6221 | -3359 |
| Uqcrc1 | 3404 | 782 | 1788 | 127 | -1968 |
| Uqcrc2 | -1038 | 5252 | -7454 | 8035 | -6299 |
| Uqcrfs1 | 1307 | 3712 | -825 | -1154 | -5658 |
| Uqcrh | 5525 | 3144 | -4076 | -3417 | -3580 |
| Uqcrq | 5570 | 4200 | -2706 | -5670 | -40 |
ASPARTATE AND ASPARAGINE METABOLISM
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00105 |
| p.adjustMANOVA | 0.00525 |
| s.dist | 0.897 |
| s.hyp | -0.379 |
| s.amy | 0.535 |
| s.hip | -0.192 |
| s.pag | 0.426 |
| s.ni | -0.395 |
| p.hyp | 0.0381 |
| p.amy | 0.00338 |
| p.hip | 0.294 |
| p.pag | 0.0197 |
| p.ni | 0.0304 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | pag |
|---|---|---|
| Folh1 | 6400 | 8825 |
| Asns | 7217 | 7416 |
| Got1 | 6301 | 6028 |
| Got2 | 5726 | 5604 |
| Aspa | 4733 | 6295 |
| Slc25a12 | 4321 | 6890 |
| Slc25a13 | 6900 | 2607 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Asns | -5965 | 7217 | -5876 | 7416 | -5779 |
| Aspa | -5353 | 4733 | -7315 | 6295 | -7137 |
| Aspg | -3106 | -5332 | 1567 | 957 | 3550 |
| Folh1 | -207 | 6400 | -1322 | 8825 | -6350 |
| Got1 | -6762 | 6301 | 692 | 6028 | -3652 |
| Got2 | -5513 | 5726 | -3253 | 5604 | -3094 |
| Naalad2 | 1436 | 5084 | -4387 | -1165 | 1071 |
| Nat8l | -6343 | 95 | 4704 | -128 | -520 |
| Slc25a12 | -4129 | 4321 | 1142 | 6890 | 1 |
| Slc25a13 | 6897 | 6900 | -149 | 2607 | -4628 |
SELENOAMINO ACID METABOLISM
| metric | value |
|---|---|
| setSize | 107 |
| pMANOVA | 4.03e-41 |
| p.adjustMANOVA | 5.19e-39 |
| s.dist | 0.895 |
| s.hyp | 0.589 |
| s.amy | 0.41 |
| s.hip | -0.493 |
| s.pag | -0.206 |
| s.ni | -0.0289 |
| p.hyp | 5.63e-26 |
| p.amy | 2.4e-13 |
| p.hip | 1.31e-18 |
| p.pag | 0.000243 |
| p.ni | 0.606 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Ahcy | 7874 | -7074 |
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Rpl27a | 6827 | -7289 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Rps3a1 | 6917 | -6741 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Rps6 | 6941 | -6279 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
| Rpl9 | 6697 | -6266 |
| Eef1e1 | 5265 | -7819 |
| Aimp1 | 5817 | -7057 |
| Rpl5 | 5400 | -7518 |
| Rps23 | 6623 | -6052 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ahcy | 7874 | 7161 | -7074 | -3141 | -1720 |
| Aimp1 | 5817 | 4631 | -7057 | -1374 | -4457 |
| Aimp2 | 7341 | 252 | -422 | 921 | -1134 |
| Cbs | 1208 | -539 | -2401 | 333 | 1581 |
| Cth | 6698 | 6682 | 2239 | 8870 | 4288 |
| Dars | -5221 | 5074 | -6953 | 6210 | -6615 |
| Eef1e1 | 5265 | 6857 | -7819 | 3031 | -5614 |
| Eefsec | 685 | -1701 | 1157 | 6308 | 342 |
| Eprs | -4001 | 821 | -4647 | -527 | 2281 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Gsr | 1846 | 5035 | -2463 | 6734 | 778 |
| Hnmt | -2746 | 7392 | -7567 | 6827 | -7060 |
| Iars | -7221 | -4947 | 5103 | 7856 | 1949 |
| Kars | 950 | 7673 | -3115 | 2957 | -4638 |
| Lars | -4308 | -5633 | -1119 | 6070 | 5759 |
| Mars1 | -2912 | -6189 | 6209 | 7802 | 3193 |
| Papss1 | 2218 | 6583 | -2573 | 8705 | 1746 |
| Papss2 | 2762 | 4910 | -4400 | 8421 | 2493 |
| Pstk | 5620 | -5637 | -5174 | 940 | -6336 |
| Qars | 6731 | 1265 | 5830 | 8728 | 4236 |
| Rars | -2964 | 1416 | -7152 | 1903 | -4214 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Sars | -7518 | 102 | -6684 | 1263 | -3619 |
| Scly | -2677 | -3250 | 1810 | 6494 | -1129 |
| Secisbp2 | -6913 | -6410 | 7776 | -4405 | 7851 |
| Sephs2 | 4567 | 3218 | -4304 | 2077 | 2101 |
| Sepsecs | -6331 | -5349 | 2115 | 382 | 60 |
| Txnrd1 | -4882 | 579 | 3348 | 2245 | 4482 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.000488 |
| p.adjustMANOVA | 0.00266 |
| s.dist | 0.873 |
| s.hyp | 0.0136 |
| s.amy | -0.389 |
| s.hip | 0.443 |
| s.pag | -0.213 |
| s.ni | 0.607 |
| p.hyp | 0.923 |
| p.amy | 0.00544 |
| p.hip | 0.00156 |
| p.pag | 0.129 |
| p.ni | 1.48e-05 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | ni | hip |
|---|---|---|
| Mov10 | 7917 | 7754 |
| Ago2 | 7975 | 6940 |
| Src | 7262 | 7491 |
| Ptpn11 | 8397 | 5624 |
| Ago3 | 7042 | 6595 |
| Pml | 6668 | 6616 |
| Ago1 | 6705 | 6556 |
| Tnrc6b | 7064 | 5028 |
| Tnrc6c | 4474 | 7019 |
| Cdk6 | 4761 | 5584 |
| Tnrc6a | 4171 | 5273 |
| Ccnd2 | 6231 | 2728 |
| Ccnd3 | 4513 | 3191 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ago1 | -2282 | -5558 | 6556 | 1397 | 6705 |
| Ago2 | 2134 | -6025 | 6940 | -1554 | 7975 |
| Ago3 | 4652 | -3438 | 6595 | 147 | 7042 |
| Ago4 | -5570 | -3507 | -3500 | -129 | 2789 |
| Cbfb | 350 | 6142 | -4169 | 6499 | -1278 |
| Ccnd1 | -2911 | -2591 | -4725 | -4100 | -1293 |
| Ccnd2 | -2199 | -5876 | 2728 | -5108 | 6231 |
| Ccnd3 | 7212 | 2775 | 3191 | 2960 | 4513 |
| Cdk6 | 4071 | -5666 | 5584 | -1312 | 4761 |
| Mov10 | 1197 | -7382 | 7754 | -6460 | 7917 |
| Pml | 37 | 5120 | 6616 | -688 | 6668 |
| Ptpn11 | 7411 | 3409 | 5624 | 8794 | 8397 |
| Runx1 | 2867 | -2438 | -2671 | -285 | 6432 |
| Src | -4246 | -5388 | 7491 | 5320 | 7262 |
| Tnrc6a | -4482 | -7683 | 5273 | -6071 | 4171 |
| Tnrc6b | 2654 | -7962 | 5028 | -5374 | 7064 |
| Tnrc6c | -7430 | -7993 | 7019 | -6366 | 4474 |
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
| metric | value |
|---|---|
| setSize | 29 |
| pMANOVA | 4.47e-06 |
| p.adjustMANOVA | 4.47e-05 |
| s.dist | 0.851 |
| s.hyp | 0.219 |
| s.amy | 0.486 |
| s.hip | -0.495 |
| s.pag | 0.109 |
| s.ni | -0.428 |
| p.hyp | 0.0409 |
| p.amy | 5.85e-06 |
| p.hip | 3.97e-06 |
| p.pag | 0.309 |
| p.ni | 6.64e-05 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Ube2r2 | -6874 | 7728 |
| Ube2l3 | -7583 | 6825 |
| Ube2g1 | -6603 | 7418 |
| Ube2d2a | -7598 | 5875 |
| Ube2a | -7124 | 6265 |
| Ube2d1 | -7577 | 5729 |
| Ube2e1 | -7551 | 5180 |
| Ube2e3 | -6960 | 5558 |
| Ube2b | -7642 | 5027 |
| Rps27a | -6007 | 6029 |
| Ube2w | -6978 | 5071 |
| Ube2q2 | -6171 | 5087 |
| Otulin | -3491 | 5309 |
| Uchl3 | -5733 | 3093 |
| Uba52 | -3631 | 4466 |
| Ube2k | -7277 | 2034 |
| Uba6 | -2637 | 4461 |
| Usp9x | -1929 | 4623 |
| Ubb | -1569 | 4257 |
| Cdc34 | -1415 | 3486 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Cdc34 | 395 | 3486 | -1415 | 62 | -4555 |
| Otulin | 3146 | 5309 | -3491 | -3454 | 711 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Uba1 | -5011 | 300 | 2090 | 6633 | 2267 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Uba6 | 3197 | 4461 | -2637 | 6979 | -5885 |
| Ubb | 78 | 4257 | -1569 | -1899 | -1838 |
| Ubc | -6658 | -637 | 164 | 5562 | 728 |
| Ube2a | 4045 | 6265 | -7124 | 5658 | -7314 |
| Ube2b | 4282 | 5027 | -7642 | 1083 | -7410 |
| Ube2d1 | 1352 | 5729 | -7577 | -3637 | -6991 |
| Ube2d2a | 3936 | 5875 | -7598 | 1933 | -6706 |
| Ube2e1 | 5911 | 5180 | -7551 | 1797 | -6934 |
| Ube2e3 | 3577 | 5558 | -6960 | 3862 | -6552 |
| Ube2g1 | 3323 | 7418 | -6603 | 7460 | -7312 |
| Ube2g2 | -1411 | -1719 | 5237 | -65 | 5462 |
| Ube2h | -1043 | 2486 | 1636 | -175 | 6615 |
| Ube2k | 1047 | 2034 | -7277 | -2961 | -6435 |
| Ube2l3 | 2394 | 6825 | -7583 | 2937 | -7074 |
| Ube2q2 | -4955 | 5087 | -6171 | 4499 | -5520 |
| Ube2r2 | 7034 | 7728 | -6874 | -4733 | -1871 |
| Ube2s | 4341 | 797 | -3082 | -1514 | -3104 |
| Ube2t | -5181 | -640 | -6644 | 268 | -5599 |
| Ube2w | 6616 | 5071 | -6978 | 6306 | -7369 |
| Ube2z | 2243 | 3979 | 904 | 3171 | 2799 |
| Uchl3 | 6280 | 3093 | -5733 | 7194 | -7217 |
| Usp5 | 3585 | 2330 | 1681 | 7371 | 3189 |
| Usp7 | -3856 | -1621 | -376 | 2483 | -1184 |
| Usp9x | 544 | 4623 | -1929 | 4615 | -2578 |
CITRIC ACID CYCLE TCA CYCLE
| metric | value |
|---|---|
| setSize | 22 |
| pMANOVA | 2.56e-05 |
| p.adjustMANOVA | 0.000217 |
| s.dist | 0.85 |
| s.hyp | 0.0601 |
| s.amy | 0.502 |
| s.hip | -0.327 |
| s.pag | 0.483 |
| s.ni | -0.358 |
| p.hyp | 0.626 |
| p.amy | 4.66e-05 |
| p.hip | 0.00795 |
| p.pag | 8.9e-05 |
| p.ni | 0.00364 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | pag |
|---|---|---|
| Idh3a | 7598 | 8335 |
| Suclg2 | 6788 | 8136 |
| Sucla2 | 6616 | 7368 |
| Idh2 | 6009 | 7609 |
| Fh1 | 4947 | 8633 |
| Dld | 4391 | 8197 |
| Aco2 | 4015 | 8125 |
| Sdha | 4989 | 6522 |
| Cs | 4756 | 5085 |
| Sdhd | 4784 | 4685 |
| Me2 | 3296 | 5869 |
| Nnt | 6296 | 3040 |
| Ogdh | 3615 | 4378 |
| Sdhc | 7450 | 1259 |
| Mdh2 | 3520 | 2088 |
| Sdhb | 4256 | 1532 |
| Suclg1 | 5077 | 919 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Aco2 | -2898 | 4015 | -767 | 8125 | -3589 |
| Cs | -6853 | 4756 | -2380 | 5085 | -632 |
| Dld | -3367 | 4391 | -7579 | 8197 | -7367 |
| Dlst | 7101 | -334 | 2486 | 5886 | 1978 |
| Fahd1 | 5601 | 1492 | -5760 | -3587 | -7105 |
| Fh1 | 3678 | 4947 | -7201 | 8633 | -4235 |
| Idh2 | 7941 | 6009 | 6237 | 7609 | 8326 |
| Idh3a | -5971 | 7598 | -6563 | 8335 | -5869 |
| Idh3b | -309 | -2317 | -330 | 7275 | -3419 |
| Idh3g | -5877 | -2052 | 4001 | 4683 | -5530 |
| Mdh2 | 3349 | 3520 | 153 | 2088 | -3794 |
| Me2 | -4206 | 3296 | -4297 | 5869 | -2039 |
| Me3 | -5546 | 51 | 855 | -876 | -6656 |
| Nnt | 4718 | 6296 | -643 | 3040 | 866 |
| Ogdh | -5190 | 3615 | 2209 | 4378 | 2595 |
| Sdha | -4231 | 4989 | -3687 | 6522 | 1446 |
| Sdhb | 2636 | 4256 | -3152 | 1532 | -5561 |
| Sdhc | 4351 | 7450 | -5449 | 1259 | -1330 |
| Sdhd | 2383 | 4784 | -4479 | 4685 | -2482 |
| Sucla2 | 1545 | 6616 | -6918 | 7368 | -7297 |
| Suclg1 | 5821 | 5077 | -4976 | 919 | -5990 |
| Suclg2 | 7899 | 6788 | -6545 | 8136 | 5835 |
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.00271 |
| p.adjustMANOVA | 0.0114 |
| s.dist | 0.842 |
| s.hyp | 0.641 |
| s.amy | 0.0985 |
| s.hip | 0.245 |
| s.pag | 0.0291 |
| s.ni | 0.478 |
| p.hyp | 0.00045 |
| p.amy | 0.59 |
| p.hip | 0.18 |
| p.pag | 0.873 |
| p.ni | 0.00887 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | ni |
|---|---|---|
| Tead2 | 7750 | 7634 |
| Yap1 | 7943 | 6237 |
| Hipk2 | 5959 | 8189 |
| Tead1 | 7093 | 6638 |
| Ccn2 | 7564 | 3043 |
| Runx2 | 2858 | 5990 |
| Tead3 | 1987 | 7183 |
| Hipk1 | 1038 | 8273 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ccn2 | 7564 | 1018 | -1418 | 8675 | 3043 |
| Hipk1 | 1038 | -2946 | 4890 | 676 | 8273 |
| Hipk2 | 5959 | -3213 | 5714 | -5307 | 8189 |
| Kat2b | 3613 | 7259 | -294 | 6080 | -4433 |
| Runx2 | 2858 | -5786 | 7741 | -5631 | 5990 |
| Tead1 | 7093 | 3324 | 7300 | 7573 | 6638 |
| Tead2 | 7750 | 5581 | -2571 | -5292 | 7634 |
| Tead3 | 1987 | 1461 | 3882 | -1941 | 7183 |
| Wwtr1 | 5926 | 6221 | -5519 | -823 | -6095 |
| Yap1 | 7943 | -6078 | 678 | 7888 | 6237 |
CRISTAE FORMATION
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 5.06e-08 |
| p.adjustMANOVA | 7.33e-07 |
| s.dist | 0.841 |
| s.hyp | 0.386 |
| s.amy | 0.423 |
| s.hip | -0.435 |
| s.pag | -0.16 |
| s.ni | -0.406 |
| p.hyp | 0.000197 |
| p.amy | 4.59e-05 |
| p.hip | 2.74e-05 |
| p.pag | 0.123 |
| p.ni | 9.3e-05 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Atp5c1 | -7104 | 7306 |
| Atp5pb | -7330 | 6938 |
| Apoo | -7725 | 6416 |
| Atp5b | -6205 | 7634 |
| Atp5a1 | -5773 | 7567 |
| mt-Atp6 | -6899 | 6269 |
| Atp5h | -6889 | 5801 |
| Immt | -5030 | 7071 |
| Hspa9 | -6951 | 4260 |
| Apool | -4674 | 5841 |
| Mtx2 | -7274 | 3171 |
| Chchd3 | -3802 | 6060 |
| Atp5g3 | -5342 | 4000 |
| Atp5j | -5767 | 3599 |
| Dmac2l | -6905 | 2673 |
| Atp5o | -4472 | 3792 |
| Micos13 | -2073 | 5058 |
| Atp5l | -5464 | 1630 |
| Micos10 | -6733 | 980 |
| Atp5j2 | -3474 | 1314 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Apoo | -1045 | 6416 | -7725 | -2024 | -7431 |
| Apool | -6773 | 5841 | -4674 | 5986 | -6028 |
| Atp5a1 | 3259 | 7567 | -5773 | 6434 | -3165 |
| Atp5b | 2580 | 7634 | -6205 | 5297 | -4923 |
| Atp5c1 | 3289 | 7306 | -7104 | 6710 | -7264 |
| Atp5d | 4949 | 1682 | 1455 | -4840 | -1505 |
| Atp5e | 6876 | 1262 | -3047 | -6025 | 971 |
| Atp5g1 | 3139 | 1013 | 4289 | 1068 | 361 |
| Atp5g2 | 7811 | -2849 | 6005 | -4684 | 731 |
| Atp5g3 | 5588 | 4000 | -5342 | -1122 | -3369 |
| Atp5h | 5830 | 5801 | -6889 | -3993 | -4997 |
| Atp5j | 3593 | 3599 | -5767 | -2771 | -1274 |
| Atp5j2 | 3630 | 1314 | -3474 | -3387 | -2120 |
| Atp5k | 6670 | 340 | 5008 | -6472 | 2070 |
| Atp5l | 6034 | 1630 | -5464 | 364 | -5543 |
| Atp5o | 89 | 3792 | -4472 | -1017 | -5634 |
| Atp5pb | 768 | 6938 | -7330 | 3305 | -7063 |
| Chchd3 | 4655 | 6060 | -3802 | 6132 | -4864 |
| Chchd6 | 6133 | -13 | -2225 | -2861 | -279 |
| Dmac2l | 1829 | 2673 | -6905 | -2688 | -7271 |
| Dnajc11 | -6373 | -969 | 3383 | 25 | 2635 |
| Hspa9 | -4745 | 4260 | -6951 | 3401 | -2332 |
| Immt | 986 | 7071 | -5030 | 8554 | -4728 |
| Micos10 | 4354 | 980 | -6733 | -3725 | -3678 |
| Micos13 | 6748 | 5058 | -2073 | -2196 | -2605 |
| mt-Atp6 | 5939 | 6269 | -6899 | -2601 | -4258 |
| mt-Atp8 | 7480 | 6132 | -19 | -4236 | 7576 |
| Mtx1 | 4675 | -1658 | 3314 | -2612 | 255 |
| Mtx2 | 5285 | 3171 | -7274 | 1341 | -7115 |
| Samm50 | 3591 | -2057 | -2672 | 4133 | 132 |
| Tmem11 | 911 | 514 | -3326 | -5014 | -1931 |
NONSENSE MEDIATED DECAY NMD
| metric | value |
|---|---|
| setSize | 109 |
| pMANOVA | 1.64e-37 |
| p.adjustMANOVA | 1.58e-35 |
| s.dist | 0.831 |
| s.hyp | 0.529 |
| s.amy | 0.364 |
| s.hip | -0.441 |
| s.pag | -0.289 |
| s.ni | -0.00929 |
| p.hyp | 1.31e-21 |
| p.amy | 5.21e-11 |
| p.hip | 1.89e-15 |
| p.pag | 1.96e-07 |
| p.ni | 0.867 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Rpl27a | 6827 | -7289 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Rps3a1 | 6917 | -6741 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Magoh | 7230 | -6148 |
| Rps6 | 6941 | -6279 |
| Rbm8a | 5810 | -7449 |
| Rps3 | 7019 | -6125 |
| Rps27a | 7081 | -6007 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
| Rpl9 | 6697 | -6266 |
| Rpl5 | 5400 | -7518 |
| Rps23 | 6623 | -6052 |
| Rps4x | 6042 | -6597 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Casc3 | -3775 | -7687 | 6712 | -2910 | 5520 |
| Dcp1a | -4782 | -3197 | 4943 | -604 | -785 |
| Eif4a3 | 3288 | 4306 | -1393 | 4988 | 1088 |
| Eif4g1 | -2092 | -6035 | 3639 | 39 | 6314 |
| Etf1 | -5023 | 4915 | -6799 | 1359 | -5204 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Gspt1 | -2197 | 4678 | 1979 | 6292 | -1787 |
| Gspt2 | -4475 | -2821 | 258 | 4156 | -1367 |
| Magoh | 7230 | -2216 | -6148 | 3227 | -6790 |
| Magohb | -6311 | 4535 | -3666 | -1774 | -6282 |
| Ncbp1 | 6211 | 4117 | 2870 | 8014 | 3604 |
| Ncbp2 | -4956 | -1964 | -7183 | 1836 | -5504 |
| Pabpc1 | 5165 | 6207 | -6818 | -150 | 1038 |
| Pnrc2 | 4844 | 6451 | -6513 | 7159 | -4879 |
| Ppp2ca | -2555 | 5754 | -6689 | 4842 | -5975 |
| Ppp2r1a | -4108 | 5536 | 750 | 4346 | -1435 |
| Ppp2r2a | -4979 | 7401 | -7325 | 6875 | -5280 |
| Rbm8a | 5810 | 7278 | -7449 | -4576 | -2717 |
| Rnps1 | -1892 | 1589 | 834 | -2071 | 4411 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Smg1 | 250 | -7612 | 6998 | 4031 | 3053 |
| Smg5 | -3666 | -6111 | 7920 | -649 | 5249 |
| Smg6 | -6219 | -7886 | 4920 | -3783 | 6702 |
| Smg7 | -269 | -5648 | 4600 | 2523 | 4661 |
| Smg8 | -4940 | 3676 | 3925 | -571 | -1839 |
| Smg9 | -6354 | -4418 | 5953 | -2268 | 4832 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Upf1 | -2577 | -7221 | 7369 | -1152 | 7847 |
| Upf2 | -48 | -5580 | -3727 | -6134 | 1775 |
| Upf3a | -1347 | -3136 | -2142 | -3867 | 4797 |
| Upf3b | -562 | 1990 | -6123 | -6205 | 2886 |
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS
| metric | value |
|---|---|
| setSize | 15 |
| pMANOVA | 1.58e-05 |
| p.adjustMANOVA | 0.000142 |
| s.dist | 0.82 |
| s.hyp | 0.365 |
| s.amy | 0.478 |
| s.hip | 0.0412 |
| s.pag | 0.356 |
| s.ni | 0.426 |
| p.hyp | 0.0143 |
| p.amy | 0.00135 |
| p.hip | 0.782 |
| p.pag | 0.017 |
| p.ni | 0.00427 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | ni |
|---|---|---|
| Hif3a | 6236 | 7689 |
| Fgf2 | 5674 | 7600 |
| Sall1 | 6095 | 5627 |
| Epas1 | 3802 | 8368 |
| Stat3 | 3691 | 8038 |
| Sox2 | 7455 | 3146 |
| Klf4 | 5721 | 3866 |
| Smad4 | 6705 | 2031 |
| Foxp1 | 2262 | 3370 |
| Pbx1 | 547 | 7597 |
| Hhex | 6347 | 311 |
| Smad2 | 2973 | 366 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Epas1 | 7777 | 3802 | 5400 | 6669 | 8368 |
| Fgf2 | 7788 | 5674 | 4948 | 7943 | 7600 |
| Foxp1 | 766 | 2262 | -6590 | -2450 | 3370 |
| Hhex | -4210 | 6347 | -2643 | 2716 | 311 |
| Hif3a | 7469 | 6236 | 7941 | 8273 | 7689 |
| Klf4 | 6588 | 5721 | -2132 | 5766 | 3866 |
| Nr6a1 | 6435 | -5663 | 7229 | 3523 | 3670 |
| Pbx1 | 5249 | 547 | -5224 | -6003 | 7597 |
| Sall1 | 3542 | 6095 | 6255 | 8154 | 5627 |
| Smad2 | -2839 | 2973 | -5287 | 5900 | 366 |
| Smad4 | 744 | 6705 | 628 | 414 | 2031 |
| Sox2 | 1027 | 7455 | -6629 | 1626 | 3146 |
| Stat3 | -1618 | 3691 | 5985 | 1202 | 8038 |
| Tsc22d1 | 3719 | 3131 | -1813 | 5124 | -2272 |
| Zic3 | 2427 | 392 | -1700 | 7834 | -1592 |
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS
| metric | value |
|---|---|
| setSize | 20 |
| pMANOVA | 0.000277 |
| p.adjustMANOVA | 0.00163 |
| s.dist | 0.817 |
| s.hyp | 0.0615 |
| s.amy | 0.529 |
| s.hip | -0.36 |
| s.pag | 0.399 |
| s.ni | -0.307 |
| p.hyp | 0.634 |
| p.amy | 4.21e-05 |
| p.hip | 0.00533 |
| p.pag | 0.00199 |
| p.ni | 0.0174 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | pag |
|---|---|---|
| Acsbg1 | 7267 | 8731 |
| Acsl3 | 7252 | 8490 |
| Hsd17b12 | 7574 | 7479 |
| Hacd2 | 6918 | 6815 |
| Elovl1 | 7825 | 5957 |
| Elovl2 | 5340 | 8367 |
| Elovl5 | 7482 | 5777 |
| Elovl4 | 6578 | 6221 |
| Acsl4 | 5523 | 6958 |
| Acsl1 | 4086 | 7155 |
| Acsl6 | 3453 | 8026 |
| Hacd3 | 7477 | 1061 |
| Elovl6 | 1372 | 3449 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acsbg1 | 4886 | 7267 | -20 | 8731 | 3249 |
| Acsf3 | -278 | -5090 | -388 | 3775 | 467 |
| Acsl1 | -7442 | 4086 | 1606 | 7155 | 3316 |
| Acsl3 | -4551 | 7252 | -6509 | 8490 | -6017 |
| Acsl4 | -70 | 5523 | -6182 | 6958 | -89 |
| Acsl5 | -7674 | -902 | -7197 | 3498 | 491 |
| Acsl6 | -3740 | 3453 | -2019 | 8026 | -5542 |
| Elovl1 | 6176 | 7825 | 4111 | 5957 | 1577 |
| Elovl2 | 7708 | 5340 | -5840 | 8367 | -6904 |
| Elovl4 | 3659 | 6578 | -6222 | 6221 | -7068 |
| Elovl5 | 956 | 7482 | -7068 | 5777 | -5835 |
| Elovl6 | -774 | 1372 | 2800 | 3449 | 2537 |
| Elovl7 | -3777 | 3470 | -7162 | -5180 | -7233 |
| Hacd1 | 6455 | 7131 | -5397 | -4770 | -3705 |
| Hacd2 | 6558 | 6918 | -1590 | 6815 | -1480 |
| Hacd3 | 1435 | 7477 | -7338 | 1061 | -5578 |
| Hacd4 | 1229 | -239 | -406 | 6346 | -910 |
| Hsd17b12 | 1896 | 7574 | -7757 | 7479 | -6879 |
| Slc27a3 | -1379 | -4791 | 7438 | -2143 | 4412 |
| Tecr | 381 | 4133 | 95 | -3595 | 2116 |
MITOCHONDRIAL TRANSLATION
| metric | value |
|---|---|
| setSize | 93 |
| pMANOVA | 2.05e-25 |
| p.adjustMANOVA | 1.48e-23 |
| s.dist | 0.815 |
| s.hyp | 0.363 |
| s.amy | 0.365 |
| s.hip | -0.418 |
| s.pag | -0.207 |
| s.ni | -0.427 |
| p.hyp | 1.48e-09 |
| p.amy | 1.18e-09 |
| p.hip | 3.34e-12 |
| p.pag | 0.000555 |
| p.ni | 1.16e-12 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | ni | hip |
|---|---|---|
| Ptcd3 | -7248 | -7024 |
| Mrps30 | -6715 | -7472 |
| Mrps22 | -6544 | -7537 |
| Mrpl50 | -6395 | -7619 |
| Mrpl1 | -6755 | -7091 |
| Mrps31 | -6182 | -7582 |
| Mrpl32 | -6808 | -6616 |
| Mrpl47 | -7021 | -6360 |
| Mrpl16 | -6577 | -6604 |
| Mrpl15 | -5360 | -7344 |
| Mrpl42 | -6768 | -5765 |
| Mrps2 | -6984 | -5195 |
| Mrps23 | -5139 | -6806 |
| Chchd1 | -5475 | -6372 |
| Mrpl13 | -4887 | -6880 |
| Mrpl18 | -6340 | -5270 |
| Mrpl34 | -5040 | -6327 |
| Mrps36 | -4574 | -6964 |
| Mrpl48 | -4342 | -7128 |
| Mrpl35 | -5251 | -5854 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Aurkaip1 | 4611 | 5556 | -4158 | -2250 | -302 |
| Chchd1 | 6264 | 4827 | -6372 | -732 | -5475 |
| Dap3 | 5422 | 520 | 3034 | 5017 | 4722 |
| Eral1 | 7642 | 1983 | 7054 | -1828 | 3903 |
| Gadd45gip1 | 2719 | -314 | -1319 | -4764 | -2072 |
| Gfm1 | -3979 | 2933 | -1188 | 3419 | -4260 |
| Gfm2 | 1937 | -6041 | 3375 | 2699 | -2848 |
| Mrpl1 | -7178 | 5783 | -7091 | 3983 | -6755 |
| Mrpl10 | -1128 | 2986 | -4377 | -1158 | -5370 |
| Mrpl11 | 5623 | 3943 | -5694 | -3025 | -4901 |
| Mrpl12 | 5558 | 1587 | -3991 | -1298 | -4224 |
| Mrpl13 | 2854 | 6529 | -6880 | 172 | -4887 |
| Mrpl14 | 6766 | 965 | -621 | -3626 | 1497 |
| Mrpl15 | 4456 | 7743 | -7344 | 3568 | -5360 |
| Mrpl16 | 6605 | 591 | -6604 | 8092 | -6577 |
| Mrpl17 | 4328 | 5406 | -4805 | 2558 | -2569 |
| Mrpl18 | 2426 | 4850 | -5270 | -355 | -6340 |
| Mrpl19 | -1350 | 1193 | -6675 | -3826 | -1800 |
| Mrpl2 | 4076 | 3303 | 690 | -1587 | 996 |
| Mrpl20 | 4100 | -706 | -337 | -3007 | -3120 |
| Mrpl21 | 3578 | 2582 | -2101 | -4464 | -4436 |
| Mrpl22 | -3187 | 4922 | -2252 | 3050 | -6076 |
| Mrpl23 | 7764 | 926 | -4395 | -4346 | -180 |
| Mrpl24 | 5256 | 4553 | -4499 | -3876 | -625 |
| Mrpl27 | 3425 | -2044 | -2424 | -3073 | -3270 |
| Mrpl28 | 5329 | 4608 | -1730 | -3885 | -2166 |
| Mrpl3 | 1819 | -797 | -4430 | 5608 | -6751 |
| Mrpl30 | 2374 | 6913 | -5617 | -771 | -4225 |
| Mrpl32 | 6512 | 6672 | -6616 | 2589 | -6808 |
| Mrpl33 | 4617 | 4413 | -6852 | -4555 | -3786 |
| Mrpl34 | 5230 | 7082 | -6327 | 318 | -5040 |
| Mrpl35 | 6295 | 3588 | -5854 | 2455 | -5251 |
| Mrpl36 | 6195 | 355 | -1090 | 525 | -4105 |
| Mrpl37 | 5532 | -1016 | 5131 | 6906 | -3080 |
| Mrpl38 | 234 | 960 | 2803 | -706 | 3774 |
| Mrpl39 | -775 | 4604 | -5900 | 1226 | -4144 |
| Mrpl4 | 5367 | -1136 | 6687 | 743 | -1214 |
| Mrpl40 | 654 | 3610 | -5046 | -183 | -6023 |
| Mrpl41 | 5151 | 2195 | -2580 | -2536 | -471 |
| Mrpl42 | 4374 | 6563 | -5765 | -1981 | -6768 |
| Mrpl43 | 5125 | 3935 | -4195 | -1598 | -3610 |
| Mrpl44 | -3001 | 4165 | -3911 | -2584 | -1920 |
| Mrpl46 | 5011 | 2591 | -2727 | -1258 | -4210 |
| Mrpl47 | 6599 | 6552 | -6360 | 350 | -7021 |
| Mrpl48 | 4330 | 7384 | -7128 | -5139 | -4342 |
| Mrpl49 | 502 | 1746 | -3362 | 3399 | -3180 |
| Mrpl50 | 960 | 5194 | -7619 | 2546 | -6395 |
| Mrpl51 | 7705 | 5527 | -3026 | -5198 | -4232 |
| Mrpl52 | 6884 | 3947 | -1776 | -2919 | -897 |
| Mrpl53 | 5844 | -1840 | 239 | -2804 | -1608 |
| Mrpl54 | 4382 | 6379 | -5931 | -4562 | -2637 |
| Mrpl55 | -4624 | -978 | -564 | -5392 | -1687 |
| Mrpl57 | 4421 | 1933 | 823 | -4634 | -1422 |
| Mrpl58 | 1874 | -766 | 1779 | -2467 | -723 |
| Mrpl9 | 7160 | -3583 | -3015 | 2967 | -1532 |
| Mrps10 | 215 | 6504 | -5895 | -4119 | -2964 |
| Mrps11 | 2034 | -159 | 1667 | -561 | -1266 |
| Mrps12 | 587 | -103 | -673 | -3985 | -3418 |
| Mrps14 | 4293 | 4594 | -5435 | -71 | -5446 |
| Mrps15 | 5880 | 6004 | -631 | -595 | -388 |
| Mrps16 | 4560 | 1621 | -3780 | -669 | -755 |
| Mrps17 | 5913 | 45 | -2768 | -3133 | -496 |
| Mrps18a | 738 | 4318 | -3884 | -2801 | -3967 |
| Mrps18b | 1743 | 900 | -4177 | -4600 | -3320 |
| Mrps18c | 6156 | 3946 | -7291 | -2160 | -3895 |
| Mrps2 | -679 | 6952 | -5195 | -5968 | -6984 |
| Mrps21 | 4226 | 1794 | -2311 | -6158 | -2708 |
| Mrps22 | 1962 | 6321 | -7537 | 4373 | -6544 |
| Mrps23 | 5780 | 2985 | -6806 | -4090 | -5139 |
| Mrps24 | 3531 | 4277 | -2133 | -1323 | -1552 |
| Mrps25 | 1236 | 1177 | -6177 | -2178 | -1114 |
| Mrps26 | 3476 | -1196 | -227 | -2826 | 883 |
| Mrps27 | 4176 | -1009 | 3551 | -1848 | -3926 |
| Mrps28 | 416 | -534 | -3742 | 2382 | -134 |
| Mrps30 | 5314 | 5326 | -7472 | 7828 | -6715 |
| Mrps31 | -6680 | 7791 | -7582 | 8342 | -6182 |
| Mrps33 | 4152 | 4822 | -5210 | -3517 | -4042 |
| Mrps34 | 3686 | -2321 | 1713 | -4718 | 1723 |
| Mrps35 | 7589 | 3518 | -6127 | 550 | -3981 |
| Mrps36 | 105 | 7223 | -6964 | -949 | -4574 |
| Mrps5 | -6447 | 4310 | -6130 | -2534 | 1182 |
| Mrps6 | 7256 | 3068 | -3407 | 2688 | 879 |
| Mrps7 | 4784 | 3071 | -4768 | 673 | -2043 |
| Mrps9 | 6322 | 2199 | -3783 | -1118 | -2721 |
| Mrrf | -1481 | 2372 | -1183 | 5134 | -6127 |
| Mtfmt | 2567 | 2832 | 1541 | -5836 | 595 |
| Mtif2 | 48 | -3943 | -4337 | 4826 | -7026 |
| Mtif3 | -4101 | 403 | -5727 | -1994 | -240 |
| Mtrf1l | 2219 | -622 | -4685 | 5295 | 5810 |
| Oxa1l | 3524 | 5316 | 5552 | -1536 | -2315 |
| Ptcd3 | -7510 | 3652 | -7024 | 6757 | -7248 |
| Tsfm | 2540 | 1880 | -5035 | -5900 | -765 |
| Tufm | 4153 | 3962 | 1136 | -2235 | 538 |
BRANCHED CHAIN AMINO ACID CATABOLISM
| metric | value |
|---|---|
| setSize | 21 |
| pMANOVA | 3.85e-05 |
| p.adjustMANOVA | 0.00031 |
| s.dist | 0.809 |
| s.hyp | 0.411 |
| s.amy | 0.405 |
| s.hip | -0.279 |
| s.pag | 0.443 |
| s.ni | -0.22 |
| p.hyp | 0.00112 |
| p.amy | 0.00133 |
| p.hip | 0.0271 |
| p.pag | 0.000437 |
| p.ni | 0.0807 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | pag | hyp |
|---|---|---|
| Ivd | 8250 | 7410 |
| Acad8 | 6686 | 7823 |
| Aldh6a1 | 8764 | 5718 |
| Bcat2 | 6294 | 7892 |
| Acadsb | 6362 | 7431 |
| Dbt | 6820 | 6057 |
| Mccc1 | 5006 | 7648 |
| Bckdhb | 6255 | 5887 |
| Echs1 | 7893 | 4460 |
| Mccc2 | 5530 | 5560 |
| Hibadh | 7590 | 2304 |
| Hsd17b10 | 2998 | 4706 |
| Acat1 | 7789 | 1455 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acad8 | 7823 | -177 | 5884 | 6686 | -3399 |
| Acadsb | 7431 | 4845 | -5875 | 6362 | -5068 |
| Acat1 | 1455 | 1790 | -5123 | 7789 | -7012 |
| Aldh6a1 | 5718 | 7107 | -5430 | 8764 | -6183 |
| Auh | -3149 | 6791 | -5346 | -1656 | -6472 |
| Bcat1 | -5453 | 7125 | 780 | 2229 | 1924 |
| Bcat2 | 7892 | -7042 | 6679 | 6294 | 7554 |
| Bckdha | 5548 | 3055 | -541 | -1030 | 4693 |
| Bckdhb | 5887 | 7753 | -4443 | 6255 | -6786 |
| Bckdk | -3412 | 1541 | -1829 | -931 | -2433 |
| Dbt | 6057 | 5753 | -2087 | 6820 | 4712 |
| Dld | -3367 | 4391 | -7579 | 8197 | -7367 |
| Echs1 | 4460 | 3959 | -6302 | 7893 | -3861 |
| Hibadh | 2304 | 7761 | -7777 | 7590 | -6545 |
| Hibch | 1028 | 2938 | -7413 | -57 | -4447 |
| Hsd17b10 | 4706 | 6108 | -7313 | 2998 | -4748 |
| Ivd | 7410 | 4950 | 7121 | 8250 | 6831 |
| Mccc1 | 7648 | -1814 | 4737 | 5006 | 5590 |
| Mccc2 | 5560 | 1102 | -2431 | 5530 | -2733 |
| Ppm1k | 6370 | -5636 | -5403 | -5506 | 2879 |
| Slc25a44 | -1607 | 2947 | 5405 | 6366 | 6319 |
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00197 |
| p.adjustMANOVA | 0.00856 |
| s.dist | 0.804 |
| s.hyp | 0.412 |
| s.amy | 0.466 |
| s.hip | -0.0991 |
| s.pag | 0.469 |
| s.ni | 0.169 |
| p.hyp | 0.0134 |
| p.amy | 0.00522 |
| p.hip | 0.552 |
| p.pag | 0.00487 |
| p.ni | 0.312 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | pag | amy |
|---|---|---|
| Hsd17b4 | 8480 | 7110 |
| Elovl1 | 5957 | 7825 |
| Elovl2 | 8367 | 5340 |
| Elovl5 | 5777 | 7482 |
| Acox1 | 8281 | 5060 |
| Fads2 | 8081 | 4523 |
| Scp2 | 4015 | 7348 |
| Acsl1 | 7155 | 4086 |
| Fads1 | 6817 | 4081 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Abcd1 | 2137 | -2334 | 7118 | -3778 | 4568 |
| Acaa1a | 7035 | -6401 | 2835 | -454 | 2085 |
| Acot8 | 6151 | -1000 | 2978 | -2563 | 5117 |
| Acox1 | -1875 | 5060 | 91 | 8281 | 6012 |
| Acsl1 | -7442 | 4086 | 1606 | 7155 | 3316 |
| Elovl1 | 6176 | 7825 | 4111 | 5957 | 1577 |
| Elovl2 | 7708 | 5340 | -5840 | 8367 | -6904 |
| Elovl5 | 956 | 7482 | -7068 | 5777 | -5835 |
| Fads1 | 4538 | 4081 | -3681 | 6817 | 5541 |
| Fads2 | 6799 | 4523 | -681 | 8081 | 7420 |
| Hsd17b4 | 1745 | 7110 | -3023 | 8480 | 4136 |
| Scp2 | 6439 | 7348 | -6691 | 4015 | -5244 |
CD28 DEPENDENT VAV1 PATHWAY
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0358 |
| p.adjustMANOVA | 0.0861 |
| s.dist | 0.783 |
| s.hyp | 0.144 |
| s.amy | 0.4 |
| s.hip | -0.498 |
| s.pag | 0.346 |
| s.ni | -0.252 |
| p.hyp | 0.429 |
| p.amy | 0.0284 |
| p.hip | 0.00638 |
| p.pag | 0.0579 |
| p.ni | 0.167 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Cdc42 | -7712 | 6100 |
| Rac1 | -5356 | 7425 |
| Pak2 | -4607 | 7647 |
| Pak1 | -7592 | 4281 |
| Pak3 | -6355 | 4091 |
| Cd86 | -4618 | 4092 |
| Grb2 | -2556 | 1098 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Cd86 | 1176 | 4092 | -4618 | 338 | -273 |
| Cdc42 | 3468 | 6100 | -7712 | 4029 | -7011 |
| Fyn | -2944 | 222 | 912 | 8170 | 924 |
| Grb2 | -1664 | 1098 | -2556 | -1688 | 330 |
| Lck | 3317 | -4004 | -1650 | 1715 | 890 |
| Pak1 | -6015 | 4281 | -7592 | 6992 | -6412 |
| Pak2 | 1090 | 7647 | -4607 | 8226 | -21 |
| Pak3 | 2365 | 4091 | -6355 | -5027 | 1707 |
| Rac1 | 4034 | 7425 | -5356 | 8115 | -4860 |
| Vav1 | 7571 | -188 | 1045 | 6163 | -489 |
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
| metric | value |
|---|---|
| setSize | 46 |
| pMANOVA | 8.14e-10 |
| p.adjustMANOVA | 1.93e-08 |
| s.dist | 0.783 |
| s.hyp | 0.419 |
| s.amy | 0.38 |
| s.hip | -0.458 |
| s.pag | -0.0182 |
| s.ni | -0.287 |
| p.hyp | 8.57e-07 |
| p.amy | 8.36e-06 |
| p.hip | 7.51e-08 |
| p.pag | 0.831 |
| p.ni | 0.000768 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | hyp |
|---|---|---|
| Psma3 | -7487 | 6689 |
| Psme2 | -6092 | 7551 |
| Psmd14 | -7043 | 6263 |
| Psmd10 | -6728 | 6334 |
| Psmb7 | -6834 | 5788 |
| Psmb1 | -7079 | 5425 |
| Psma1 | -6200 | 5607 |
| Psmd7 | -6184 | 5456 |
| Psmd8 | -5938 | 5672 |
| Psmd6 | -6922 | 4797 |
| Psma6 | -7560 | 4239 |
| Psma2 | -6867 | 4294 |
| Psmc5 | -4264 | 6183 |
| Psma5 | -6615 | 3320 |
| Psmb4 | -3786 | 5773 |
| Psma7 | -4971 | 4346 |
| Psmb8 | -6296 | 3416 |
| Sem1 | -3003 | 6676 |
| Psmc3 | -2887 | 5782 |
| Psmb10 | -2384 | 5365 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Fcgr1 | 1799 | 4046 | -3549 | 3468 | 13 |
| Mrc1 | -3658 | 5311 | -5459 | -686 | -878 |
| Mrc2 | 5533 | 1301 | 408 | 5234 | 7899 |
| Psma1 | 5607 | 5569 | -6200 | 4740 | -6762 |
| Psma2 | 4294 | 5063 | -6867 | 4100 | -6533 |
| Psma3 | 6689 | 6045 | -7487 | -1551 | -2236 |
| Psma4 | 1744 | 4583 | -6652 | -1795 | -5550 |
| Psma5 | 3320 | -1473 | -6615 | 3565 | -4790 |
| Psma6 | 4239 | 5429 | -7560 | 5363 | -5732 |
| Psma7 | 4346 | 2253 | -4971 | -1615 | -2288 |
| Psmb1 | 5425 | 6831 | -7079 | 1873 | -5397 |
| Psmb10 | 5365 | -1177 | -2384 | -3872 | 1032 |
| Psmb2 | 6873 | 4670 | 1134 | -1064 | 289 |
| Psmb3 | 5155 | 748 | -798 | -1634 | -2798 |
| Psmb4 | 5773 | 5075 | -3786 | -2698 | 2437 |
| Psmb5 | 5738 | 551 | 3823 | -5056 | 1805 |
| Psmb6 | 5242 | -395 | -1575 | -982 | -213 |
| Psmb7 | 5788 | 3928 | -6834 | 520 | -5744 |
| Psmb8 | 3416 | 2736 | -6296 | -2898 | 3473 |
| Psmb9 | 840 | -4740 | -2793 | -4567 | 167 |
| Psmc1 | 1281 | 7562 | -7755 | -3569 | -2836 |
| Psmc2 | 399 | 6669 | -6312 | 1437 | -4040 |
| Psmc3 | 5782 | 1161 | -2887 | 2021 | -4413 |
| Psmc4 | 5458 | 8 | 2117 | 455 | 272 |
| Psmc5 | 6183 | 5192 | -4264 | 1969 | -5209 |
| Psmc6 | -4948 | 6646 | -7432 | 8559 | -7419 |
| Psmd1 | -1909 | 7524 | -6547 | -2340 | -251 |
| Psmd10 | 6334 | 1117 | -6728 | 3839 | -5682 |
| Psmd11 | 770 | 979 | 599 | -3449 | -1053 |
| Psmd12 | -7347 | 6210 | -7688 | 6526 | -7219 |
| Psmd13 | 6486 | -1504 | -1320 | 4364 | -2359 |
| Psmd14 | 6263 | 5290 | -7043 | 6717 | -6867 |
| Psmd2 | -866 | -163 | -93 | 7544 | 1305 |
| Psmd3 | 6426 | -50 | 6648 | 4126 | 3080 |
| Psmd4 | 3267 | 645 | 1378 | -3443 | 2189 |
| Psmd5 | -1200 | 4463 | -2977 | 7366 | -2872 |
| Psmd6 | 4797 | 5500 | -6922 | 6782 | -5316 |
| Psmd7 | 5456 | 5672 | -6184 | -1999 | 2849 |
| Psmd8 | 5672 | 7146 | -5938 | 526 | -6055 |
| Psmd9 | 6230 | 3553 | 169 | -2327 | 6271 |
| Psme1 | 4248 | 89 | -2892 | -1726 | 7024 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Psme3 | 3038 | 4952 | -3093 | 1529 | -1447 |
| Psme4 | -2265 | -7768 | 3276 | 1950 | -3256 |
| Psmf1 | -357 | 3223 | 354 | -1461 | -3409 |
| Sem1 | 6676 | 1611 | -3003 | -2719 | -2139 |
ADENYLATE CYCLASE ACTIVATING PATHWAY
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0223 |
| p.adjustMANOVA | 0.0593 |
| s.dist | 0.781 |
| s.hyp | -0.23 |
| s.amy | -0.143 |
| s.hip | 0.509 |
| s.pag | 0.215 |
| s.ni | 0.481 |
| p.hyp | 0.208 |
| p.amy | 0.433 |
| p.hip | 0.00529 |
| p.pag | 0.238 |
| p.ni | 0.00844 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | ni |
|---|---|---|
| Adcy6 | 7794 | 8014 |
| Adcy4 | 7025 | 7160 |
| Adcy5 | 5620 | 7247 |
| Adcy3 | 5779 | 4299 |
| Adcy7 | 5309 | 4012 |
| Adcy9 | 5530 | 3537 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Adcy1 | -3123 | -7207 | 7336 | 3068 | -343 |
| Adcy2 | -464 | 1491 | -1257 | 2820 | 6940 |
| Adcy3 | -546 | 2036 | 5779 | 5238 | 4299 |
| Adcy4 | 6996 | 3862 | 7025 | -1063 | 7160 |
| Adcy5 | -1845 | 3620 | 5620 | 4738 | 7247 |
| Adcy6 | 1885 | -7721 | 7794 | -2234 | 8014 |
| Adcy7 | -6225 | -1963 | 5309 | 1594 | 4012 |
| Adcy8 | -7777 | -6860 | -3587 | 6961 | 3443 |
| Adcy9 | -4539 | -1195 | 5530 | 1771 | 3537 |
| Gnal | -1641 | 1625 | 1784 | 3763 | -1405 |
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
| metric | value |
|---|---|
| setSize | 172 |
| pMANOVA | 2.98e-39 |
| p.adjustMANOVA | 3.14e-37 |
| s.dist | 0.78 |
| s.hyp | 0.337 |
| s.amy | 0.463 |
| s.hip | -0.404 |
| s.pag | -0.0909 |
| s.ni | -0.331 |
| p.hyp | 2.52e-14 |
| p.amy | 1.12e-25 |
| p.hip | 6.74e-20 |
| p.pag | 0.04 |
| p.ni | 7.28e-14 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hip |
|---|---|---|
| Ndufv2 | 7605 | -7699 |
| mt-Co1 | 7585 | -7593 |
| mt-Nd3 | 7407 | -7691 |
| Ndufaf4 | 7583 | -7294 |
| Cycs | 7058 | -7801 |
| mt-Nd1 | 7301 | -7258 |
| Ndufs4 | 7230 | -7264 |
| Atp5c1 | 7306 | -7104 |
| Ndufa10 | 7194 | -7175 |
| mt-Nd2 | 7154 | -7176 |
| mt-Nd4 | 7499 | -6839 |
| Cox7a2l | 7474 | -6861 |
| Atp5pb | 6938 | -7330 |
| Ndufb5 | 7652 | -6546 |
| Idh3a | 7598 | -6563 |
| mt-Co2 | 7208 | -6777 |
| mt-Nd6 | 7403 | -6543 |
| Coq10b | 7725 | -6240 |
| Pdha1 | 6981 | -6893 |
| Ndufaf1 | 6859 | -7003 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acad9 | -223 | 1892 | 1303 | 8381 | -2268 |
| Aco2 | -2898 | 4015 | -767 | 8125 | -3589 |
| Adhfe1 | 2107 | 4264 | -5074 | 7871 | -3746 |
| Atp5a1 | 3259 | 7567 | -5773 | 6434 | -3165 |
| Atp5b | 2580 | 7634 | -6205 | 5297 | -4923 |
| Atp5c1 | 3289 | 7306 | -7104 | 6710 | -7264 |
| Atp5d | 4949 | 1682 | 1455 | -4840 | -1505 |
| Atp5e | 6876 | 1262 | -3047 | -6025 | 971 |
| Atp5g1 | 3139 | 1013 | 4289 | 1068 | 361 |
| Atp5g2 | 7811 | -2849 | 6005 | -4684 | 731 |
| Atp5g3 | 5588 | 4000 | -5342 | -1122 | -3369 |
| Atp5h | 5830 | 5801 | -6889 | -3993 | -4997 |
| Atp5j | 3593 | 3599 | -5767 | -2771 | -1274 |
| Atp5j2 | 3630 | 1314 | -3474 | -3387 | -2120 |
| Atp5k | 6670 | 340 | 5008 | -6472 | 2070 |
| Atp5l | 6034 | 1630 | -5464 | 364 | -5543 |
| Atp5o | 89 | 3792 | -4472 | -1017 | -5634 |
| Atp5pb | 768 | 6938 | -7330 | 3305 | -7063 |
| Bsg | 3052 | 3183 | -5921 | -4256 | -4777 |
| Coq10a | 1571 | 5130 | 519 | -5431 | -3676 |
| Coq10b | 5602 | 7725 | -6240 | 7945 | -5653 |
| Cox11 | 1247 | -6664 | 1029 | 4408 | -817 |
| Cox14 | 1992 | -2141 | -2254 | -6080 | -3801 |
| Cox16 | 5115 | 4512 | -5735 | -650 | -6476 |
| Cox18 | 2726 | 3991 | 5549 | 8672 | 1514 |
| Cox19 | -963 | -4171 | -1598 | -3117 | 1112 |
| Cox20 | 4823 | 5088 | -7140 | -5870 | -922 |
| Cox4i1 | 5752 | 396 | -3641 | -2516 | -1900 |
| Cox5a | 4851 | 6815 | -3955 | -1299 | -5292 |
| Cox5b | 5594 | 5054 | 476 | -6692 | 1155 |
| Cox6a1 | 6831 | 6256 | -938 | -4503 | -2165 |
| Cox6b1 | 5128 | 1661 | -1189 | -4984 | -3965 |
| Cox6c | 4661 | 4697 | -5262 | -3482 | -905 |
| Cox7a2l | 5822 | 7474 | -6861 | -2784 | -2169 |
| Cox7b | 2531 | 4315 | -6488 | -4310 | -5044 |
| Cox7c | 4839 | 5580 | -3904 | -4569 | -1844 |
| Cox8a | 5257 | 4348 | 625 | -4317 | 2677 |
| Cs | -6853 | 4756 | -2380 | 5085 | -632 |
| Cyc1 | 5208 | 2214 | 695 | 4719 | -4024 |
| Cycs | 1049 | 7058 | -7801 | -4513 | -7336 |
| D2hgdh | -527 | -1082 | 5699 | -1117 | 5723 |
| Dlat | -3061 | 7311 | -4099 | -546 | -6309 |
| Dld | -3367 | 4391 | -7579 | 8197 | -7367 |
| Dlst | 7101 | -334 | 2486 | 5886 | 1978 |
| Dmac2l | 1829 | 2673 | -6905 | -2688 | -7271 |
| Ecsit | 5803 | 2232 | 5019 | -1685 | -732 |
| Etfa | 3333 | 2979 | -6847 | 5560 | -5752 |
| Etfb | 5300 | 1903 | -4960 | -4885 | 845 |
| Etfdh | -4233 | 1052 | -4448 | 7841 | -4439 |
| Fahd1 | 5601 | 1492 | -5760 | -3587 | -7105 |
| Fh1 | 3678 | 4947 | -7201 | 8633 | -4235 |
| Glo1 | 3356 | 6444 | -7116 | 409 | -4241 |
| Gstz1 | 2456 | -4044 | -1765 | -2760 | 1470 |
| Hagh | 1432 | 1547 | -350 | 1360 | -3023 |
| Idh2 | 7941 | 6009 | 6237 | 7609 | 8326 |
| Idh3a | -5971 | 7598 | -6563 | 8335 | -5869 |
| Idh3b | -309 | -2317 | -330 | 7275 | -3419 |
| Idh3g | -5877 | -2052 | 4001 | 4683 | -5530 |
| L2hgdh | -3482 | -1804 | -4209 | 3361 | 600 |
| Ldha | 2220 | -105 | -4896 | -608 | 5789 |
| Ldhb | 2508 | 5668 | -4417 | 3943 | -4975 |
| Lrpprc | -5902 | -6510 | -1170 | 5618 | -2059 |
| Mdh2 | 3349 | 3520 | 153 | 2088 | -3794 |
| Me1 | 1271 | 5509 | -6490 | 8464 | -5998 |
| Me2 | -4206 | 3296 | -4297 | 5869 | -2039 |
| Me3 | -5546 | 51 | 855 | -876 | -6656 |
| Mpc1 | 3967 | 6932 | -6441 | 2709 | -6482 |
| Mpc2 | 3949 | 5113 | -6947 | 3038 | -4995 |
| mt-Atp6 | 5939 | 6269 | -6899 | -2601 | -4258 |
| mt-Atp8 | 7480 | 6132 | -19 | -4236 | 7576 |
| mt-Co1 | 6248 | 7585 | -7593 | 1521 | -2151 |
| mt-Co2 | 5704 | 7208 | -6777 | 710 | -7000 |
| mt-Co3 | 5441 | 6999 | -6525 | -442 | -4781 |
| mt-Cytb | 5767 | 7124 | -6683 | -491 | -3194 |
| mt-Nd1 | 5713 | 7301 | -7258 | -2320 | -4384 |
| mt-Nd2 | 6171 | 7154 | -7176 | -1627 | -4323 |
| mt-Nd3 | 7337 | 7407 | -7691 | -6837 | 4148 |
| mt-Nd4 | 6181 | 7499 | -6839 | -1057 | -3590 |
| mt-Nd5 | 6492 | 7227 | -6216 | 322 | -1727 |
| mt-Nd6 | 6944 | 7403 | -6543 | -3132 | -5121 |
| Ndufa1 | 6747 | 2682 | -2157 | -6310 | -902 |
| Ndufa10 | -2896 | 7194 | -7175 | -8 | -6007 |
| Ndufa11 | 4790 | -871 | 691 | -2899 | -4199 |
| Ndufa12 | 3410 | 7277 | -5424 | -6559 | 746 |
| Ndufa13 | 4994 | 5596 | -100 | -5971 | 3048 |
| Ndufa2 | 7370 | -1281 | 108 | -3655 | 175 |
| Ndufa3 | 5608 | -178 | 3142 | -6518 | 2193 |
| Ndufa4 | 4002 | 6647 | -6247 | -3408 | -3885 |
| Ndufa5 | 4781 | 6830 | -5303 | -6063 | -2583 |
| Ndufa6 | 5333 | 4557 | -3639 | -3895 | -669 |
| Ndufa7 | 5517 | 4326 | -848 | -4990 | 617 |
| Ndufa8 | 3070 | 1617 | -5815 | -3232 | -821 |
| Ndufa9 | 822 | -1091 | -5785 | 788 | -3694 |
| Ndufab1 | 5137 | 5374 | -1496 | -5016 | -5345 |
| Ndufaf1 | 6359 | 6859 | -7003 | 5348 | -6792 |
| Ndufaf2 | 1248 | 5932 | -7514 | -5943 | -5310 |
| Ndufaf3 | 4088 | -1081 | -921 | -2257 | 1465 |
| Ndufaf4 | -1870 | 7583 | -7294 | 5308 | -7177 |
| Ndufaf5 | 6834 | 5437 | -6666 | 3093 | -6428 |
| Ndufaf6 | 5592 | 6328 | -4055 | 6157 | -5058 |
| Ndufaf7 | 6165 | -1131 | -2436 | 3533 | 3755 |
| Ndufb1 | 6049 | 3262 | -1698 | -1494 | 262 |
| Ndufb10 | 6235 | 295 | 87 | -1803 | -4744 |
| Ndufb11 | 6180 | 6212 | -4331 | -1647 | -4316 |
| Ndufb2 | 7123 | 1176 | -4654 | -3514 | -3366 |
| Ndufb3 | 1907 | 2377 | -5581 | -2620 | -3148 |
| Ndufb4 | 5445 | 6289 | -7102 | -1954 | -1675 |
| Ndufb5 | 4385 | 7652 | -6546 | -596 | -5663 |
| Ndufb6 | 4453 | 3990 | -6274 | -853 | -4948 |
| Ndufb7 | 4612 | 1304 | -626 | -4763 | 476 |
| Ndufb8 | 5591 | 5931 | -4210 | 862 | -3292 |
| Ndufb9 | 6089 | 6479 | -5428 | -3371 | -2916 |
| Ndufc1 | 5478 | 7587 | -6002 | -6112 | -2866 |
| Ndufc2 | 5494 | 4597 | -7659 | 2151 | -5165 |
| Ndufs1 | -3679 | 6120 | -4473 | 7932 | -5114 |
| Ndufs2 | 3514 | 7229 | -5625 | 403 | -291 |
| Ndufs3 | 6664 | 5747 | -3258 | -3881 | -4640 |
| Ndufs4 | 3311 | 7230 | -7264 | -2562 | -5432 |
| Ndufs5 | 5008 | 4499 | -4848 | -3718 | -3992 |
| Ndufs6 | 5789 | 3656 | -4610 | -5995 | 876 |
| Ndufs7 | 3848 | 2004 | 2701 | -5625 | 490 |
| Ndufs8 | 2818 | 330 | -3398 | 275 | -5753 |
| Ndufv1 | 6126 | 3309 | -2255 | -132 | -1730 |
| Ndufv2 | 2238 | 7605 | -7699 | -248 | -6974 |
| Ndufv3 | 2869 | 189 | 1197 | -6383 | 478 |
| Nnt | 4718 | 6296 | -643 | 3040 | 866 |
| Nubpl | 3656 | 22 | -5922 | -2803 | -3789 |
| Ogdh | -5190 | 3615 | 2209 | 4378 | 2595 |
| Pdha1 | -5481 | 6981 | -6893 | 7725 | -4988 |
| Pdhb | -3009 | 4912 | -6854 | 4879 | -6776 |
| Pdhx | -434 | 4617 | -5032 | 5917 | -5018 |
| Pdk1 | -1753 | -7826 | 3610 | -3820 | 8280 |
| Pdk2 | -2393 | 309 | 1905 | 5636 | 3890 |
| Pdk3 | -544 | 7681 | -4969 | 8055 | -6437 |
| Pdk4 | 1378 | 5733 | -2664 | 1962 | 3628 |
| Pdp1 | 4487 | 5582 | -6309 | 7709 | -4579 |
| Pdp2 | -2825 | -6525 | -3664 | -3981 | 3419 |
| Pdpr | -3762 | -2753 | 3730 | 4280 | 2949 |
| Pm20d1 | 6709 | 4547 | -1801 | 8437 | 2251 |
| Ppard | 3112 | 3102 | 7500 | 2666 | 7551 |
| Rxra | 5013 | 6031 | 5441 | 7066 | 8252 |
| Sco1 | -5380 | 82 | -6608 | -5698 | -5592 |
| Sco2 | -1097 | 5749 | -3040 | -4639 | -34 |
| Sdha | -4231 | 4989 | -3687 | 6522 | 1446 |
| Sdhb | 2636 | 4256 | -3152 | 1532 | -5561 |
| Sdhc | 4351 | 7450 | -5449 | 1259 | -1330 |
| Sdhd | 2383 | 4784 | -4479 | 4685 | -2482 |
| Slc16a1 | -5943 | 3850 | -7790 | -4734 | -7414 |
| Slc16a3 | -6810 | -1862 | -761 | 2139 | 7077 |
| Slc16a8 | -5521 | -7068 | 5746 | -1318 | -2475 |
| Slc25a14 | 7413 | 6546 | -6517 | 1916 | 917 |
| Slc25a27 | -6852 | -6154 | 6731 | 2552 | 1526 |
| Sucla2 | 1545 | 6616 | -6918 | 7368 | -7297 |
| Suclg1 | 5821 | 5077 | -4976 | 919 | -5990 |
| Suclg2 | 7899 | 6788 | -6545 | 8136 | 5835 |
| Surf1 | 6477 | 6722 | -4189 | 10 | -2818 |
| Taco1 | 3660 | 4751 | 5594 | 5249 | -2134 |
| Timmdc1 | 6226 | 7075 | -1523 | 4742 | 115 |
| Tmem126b | -1106 | 3081 | -4186 | 1886 | -2207 |
| Tmem186 | -6615 | -6828 | 5066 | -23 | 6133 |
| Trap1 | 2487 | -260 | 6069 | 6860 | -807 |
| Ucp2 | 7104 | 6438 | 6890 | 4528 | 8022 |
| Ucp3 | -5308 | 3825 | -7171 | 5651 | -4310 |
| Uqcr10 | 5291 | 895 | -572 | -5539 | 919 |
| Uqcr11 | 5354 | -835 | 945 | -5641 | 931 |
| Uqcrb | 2763 | 7013 | -5636 | -6221 | -3359 |
| Uqcrc1 | 3404 | 782 | 1788 | 127 | -1968 |
| Uqcrc2 | -1038 | 5252 | -7454 | 8035 | -6299 |
| Uqcrfs1 | 1307 | 3712 | -825 | -1154 | -5658 |
| Uqcrh | 5525 | 3144 | -4076 | -3417 | -3580 |
| Uqcrq | 5570 | 4200 | -2706 | -5670 | -40 |
| Vdac1 | -1447 | 5620 | -6798 | 2614 | -3737 |
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
| metric | value |
|---|---|
| setSize | 19 |
| pMANOVA | 0.000123 |
| p.adjustMANOVA | 0.000842 |
| s.dist | 0.78 |
| s.hyp | 0.335 |
| s.amy | 0.536 |
| s.hip | -0.45 |
| s.pag | 0.0793 |
| s.ni | -0.0171 |
| p.hyp | 0.0116 |
| p.amy | 5.26e-05 |
| p.hip | 0.000685 |
| p.pag | 0.55 |
| p.ni | 0.897 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hip |
|---|---|---|
| Gng12 | 7514 | -6688 |
| P2ry12 | 7127 | -6940 |
| Gng11 | 6358 | -7726 |
| Gng10 | 6843 | -6715 |
| Gnai3 | 6753 | -6714 |
| Gnai1 | 4838 | -5831 |
| Gng5 | 6766 | -4031 |
| Gng3 | 4038 | -3696 |
| Gngt2 | 2702 | -4935 |
| Gnb4 | 2512 | -4979 |
| Gng2 | 1484 | -3774 |
| Gng4 | 1921 | -2274 |
| Gnb5 | 6421 | -415 |
| Gnb1 | 561 | -4709 |
| Gng13 | 875 | -2000 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Gnai1 | -924 | 4838 | -5831 | 7661 | -4587 |
| Gnai2 | 4200 | 3912 | 432 | 6521 | 7740 |
| Gnai3 | -1545 | 6753 | -6714 | 6426 | -4086 |
| Gnb1 | 2423 | 561 | -4709 | 4581 | 2804 |
| Gnb2 | 2991 | 1299 | 1976 | -3128 | 6751 |
| Gnb4 | 5819 | 2512 | -4979 | -4204 | 1087 |
| Gnb5 | -4146 | 6421 | -415 | 6663 | -54 |
| Gng10 | 7095 | 6843 | -6715 | -307 | -2430 |
| Gng11 | 4237 | 6358 | -7726 | -4003 | -6171 |
| Gng12 | 7151 | 7514 | -6688 | 8503 | -1241 |
| Gng13 | 5363 | 875 | -2000 | -6507 | 1166 |
| Gng2 | -5580 | 1484 | -3774 | 7437 | 114 |
| Gng3 | 3292 | 4038 | -3696 | -2838 | 914 |
| Gng4 | -97 | 1921 | -2274 | -2434 | 7956 |
| Gng5 | 7546 | 6766 | -4031 | -917 | -722 |
| Gng7 | 2143 | 4902 | 2345 | 7620 | -624 |
| Gng8 | 5083 | 1976 | 835 | 3400 | 1193 |
| Gngt2 | 5942 | 2702 | -4935 | -6945 | 2786 |
| P2ry12 | 1186 | 7127 | -6940 | 2622 | -6071 |
REGULATION OF EXPRESSION OF SLITS AND ROBOS
| metric | value |
|---|---|
| setSize | 160 |
| pMANOVA | 2.36e-44 |
| p.adjustMANOVA | 3.42e-42 |
| s.dist | 0.777 |
| s.hyp | 0.475 |
| s.amy | 0.362 |
| s.hip | -0.441 |
| s.pag | -0.212 |
| s.ni | -0.0864 |
| p.hyp | 3.04e-25 |
| p.amy | 2.67e-15 |
| p.hip | 6.67e-22 |
| p.pag | 3.65e-06 |
| p.ni | 0.0596 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | hip |
|---|---|---|
| Rpl22l1 | 6909 | -7616 |
| Rpl3 | 7452 | -6912 |
| Psma3 | 6689 | -7487 |
| Rpl27a | 6827 | -7289 |
| Rps24 | 6708 | -7078 |
| Rpl35a | 6017 | -7800 |
| Rps3a1 | 6917 | -6741 |
| Psme2 | 7551 | -6092 |
| Rpl30 | 5835 | -7767 |
| Rplp0 | 5927 | -7543 |
| Magoh | 7230 | -6148 |
| Psmd14 | 6263 | -7043 |
| Rps6 | 6941 | -6279 |
| Rbm8a | 5810 | -7449 |
| Rps3 | 7019 | -6125 |
| Psmd10 | 6334 | -6728 |
| Rps27a | 7081 | -6007 |
| Rpl13a | 6978 | -6057 |
| Rps8 | 6896 | -6090 |
| Rpl36a | 5903 | -7110 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Casc3 | -3775 | -7687 | 6712 | -2910 | 5520 |
| Col4a5 | 2302 | 164 | 4803 | 2367 | 463 |
| Cul2 | -3551 | 4503 | -6426 | 8646 | -5581 |
| Dag1 | 861 | 5972 | 1791 | 6641 | 5237 |
| Eif4a3 | 3288 | 4306 | -1393 | 4988 | 1088 |
| Eif4g1 | -2092 | -6035 | 3639 | 39 | 6314 |
| Elob | 5907 | 3938 | -2825 | -4920 | -2778 |
| Eloc | 1013 | 5164 | -7415 | -3909 | -6714 |
| Etf1 | -5023 | 4915 | -6799 | 1359 | -5204 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Gspt1 | -2197 | 4678 | 1979 | 6292 | -1787 |
| Gspt2 | -4475 | -2821 | 258 | 4156 | -1367 |
| Isl1 | 5559 | 7531 | -4341 | 2288 | 7989 |
| Ldb1 | -2376 | -4222 | 6355 | -3980 | 7670 |
| Lhx2 | -4397 | -4671 | 2393 | 2850 | -1824 |
| Lhx9 | -5879 | -2318 | 1174 | 813 | 1280 |
| Magoh | 7230 | -2216 | -6148 | 3227 | -6790 |
| Magohb | -6311 | 4535 | -3666 | -1774 | -6282 |
| Msi1 | -3759 | -6083 | 5048 | -6710 | 6328 |
| Ncbp1 | 6211 | 4117 | 2870 | 8014 | 3604 |
| Ncbp2 | -4956 | -1964 | -7183 | 1836 | -5504 |
| Pabpc1 | 5165 | 6207 | -6818 | -150 | 1038 |
| Psma1 | 5607 | 5569 | -6200 | 4740 | -6762 |
| Psma2 | 4294 | 5063 | -6867 | 4100 | -6533 |
| Psma3 | 6689 | 6045 | -7487 | -1551 | -2236 |
| Psma4 | 1744 | 4583 | -6652 | -1795 | -5550 |
| Psma5 | 3320 | -1473 | -6615 | 3565 | -4790 |
| Psma6 | 4239 | 5429 | -7560 | 5363 | -5732 |
| Psma7 | 4346 | 2253 | -4971 | -1615 | -2288 |
| Psmb1 | 5425 | 6831 | -7079 | 1873 | -5397 |
| Psmb10 | 5365 | -1177 | -2384 | -3872 | 1032 |
| Psmb2 | 6873 | 4670 | 1134 | -1064 | 289 |
| Psmb3 | 5155 | 748 | -798 | -1634 | -2798 |
| Psmb4 | 5773 | 5075 | -3786 | -2698 | 2437 |
| Psmb5 | 5738 | 551 | 3823 | -5056 | 1805 |
| Psmb6 | 5242 | -395 | -1575 | -982 | -213 |
| Psmb7 | 5788 | 3928 | -6834 | 520 | -5744 |
| Psmb8 | 3416 | 2736 | -6296 | -2898 | 3473 |
| Psmb9 | 840 | -4740 | -2793 | -4567 | 167 |
| Psmc1 | 1281 | 7562 | -7755 | -3569 | -2836 |
| Psmc2 | 399 | 6669 | -6312 | 1437 | -4040 |
| Psmc3 | 5782 | 1161 | -2887 | 2021 | -4413 |
| Psmc4 | 5458 | 8 | 2117 | 455 | 272 |
| Psmc5 | 6183 | 5192 | -4264 | 1969 | -5209 |
| Psmc6 | -4948 | 6646 | -7432 | 8559 | -7419 |
| Psmd1 | -1909 | 7524 | -6547 | -2340 | -251 |
| Psmd10 | 6334 | 1117 | -6728 | 3839 | -5682 |
| Psmd11 | 770 | 979 | 599 | -3449 | -1053 |
| Psmd12 | -7347 | 6210 | -7688 | 6526 | -7219 |
| Psmd13 | 6486 | -1504 | -1320 | 4364 | -2359 |
| Psmd14 | 6263 | 5290 | -7043 | 6717 | -6867 |
| Psmd2 | -866 | -163 | -93 | 7544 | 1305 |
| Psmd3 | 6426 | -50 | 6648 | 4126 | 3080 |
| Psmd4 | 3267 | 645 | 1378 | -3443 | 2189 |
| Psmd5 | -1200 | 4463 | -2977 | 7366 | -2872 |
| Psmd6 | 4797 | 5500 | -6922 | 6782 | -5316 |
| Psmd7 | 5456 | 5672 | -6184 | -1999 | 2849 |
| Psmd8 | 5672 | 7146 | -5938 | 526 | -6055 |
| Psmd9 | 6230 | 3553 | 169 | -2327 | 6271 |
| Psme1 | 4248 | 89 | -2892 | -1726 | 7024 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Psme3 | 3038 | 4952 | -3093 | 1529 | -1447 |
| Psme4 | -2265 | -7768 | 3276 | 1950 | -3256 |
| Psmf1 | -357 | 3223 | 354 | -1461 | -3409 |
| Rbm8a | 5810 | 7278 | -7449 | -4576 | -2717 |
| Rbx1 | 1679 | 5615 | -6293 | -3312 | -4293 |
| Rnps1 | -1892 | 1589 | 834 | -2071 | 4411 |
| Robo1 | -2990 | 1523 | 3969 | 1415 | 3468 |
| Robo2 | -4859 | 1007 | 1732 | -138 | -1215 |
| Robo3 | -5608 | -5609 | 2988 | -2413 | 4150 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Sem1 | 6676 | 1611 | -3003 | -2719 | -2139 |
| Slit1 | -6537 | -6659 | 7872 | 3768 | 6633 |
| Slit2 | -4398 | -6570 | -4048 | 4732 | 4862 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Ubb | 78 | 4257 | -1569 | -1899 | -1838 |
| Ubc | -6658 | -637 | 164 | 5562 | 728 |
| Upf2 | -48 | -5580 | -3727 | -6134 | 1775 |
| Upf3a | -1347 | -3136 | -2142 | -3867 | 4797 |
| Upf3b | -562 | 1990 | -6123 | -6205 | 2886 |
| Usp33 | -3776 | 5410 | -2819 | 8239 | -6344 |
| Zswim8 | -3469 | -6983 | 7721 | 1207 | 7103 |
CRMPS IN SEMA3A SIGNALING
| metric | value |
|---|---|
| setSize | 16 |
| pMANOVA | 0.00618 |
| p.adjustMANOVA | 0.0213 |
| s.dist | 0.774 |
| s.hyp | -0.126 |
| s.amy | -0.515 |
| s.hip | 0.485 |
| s.pag | -0.0984 |
| s.ni | 0.269 |
| p.hyp | 0.384 |
| p.amy | 0.000357 |
| p.hip | 0.00079 |
| p.pag | 0.496 |
| p.ni | 0.0623 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hip |
|---|---|---|
| Plxna3 | -7417 | 7386 |
| Plxna1 | -7017 | 7694 |
| Plxna4 | -7504 | 6439 |
| Dpysl5 | -5293 | 7882 |
| Dpysl4 | -5846 | 7072 |
| Crmp1 | -5951 | 5662 |
| Plxna2 | -4146 | 6467 |
| Nrp1 | -3669 | 5553 |
| Dpysl2 | -6747 | 2622 |
| Cdk5 | -4071 | 2349 |
| Fes | -686 | 6719 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Cdk5 | 4276 | -4071 | 2349 | -1051 | -2367 |
| Cdk5r1 | -3991 | -2234 | -276 | -5166 | 99 |
| Crmp1 | -6231 | -5951 | 5662 | 3345 | 3677 |
| Dpysl2 | 7486 | -6747 | 2622 | -6760 | 5493 |
| Dpysl3 | -1877 | -5589 | -1502 | -3967 | 2380 |
| Dpysl4 | 2236 | -5846 | 7072 | 989 | 4102 |
| Dpysl5 | -2519 | -5293 | 7882 | 1698 | 8096 |
| Fes | 7914 | -686 | 6719 | 857 | 3888 |
| Fyn | -2944 | 222 | 912 | 8170 | 924 |
| Gsk3b | -1833 | -1738 | -125 | -3712 | -789 |
| Nrp1 | -4623 | -3669 | 5553 | -284 | 3962 |
| Plxna1 | -5898 | -7017 | 7694 | 2775 | 7376 |
| Plxna2 | -2055 | -4146 | 6467 | 3086 | 1916 |
| Plxna3 | 402 | -7417 | 7386 | 538 | 4151 |
| Plxna4 | -4258 | -7504 | 6439 | -4670 | 5863 |
| Sema3a | -495 | 828 | -1872 | 7022 | -6992 |
BLOOD GROUP SYSTEMS BIOSYNTHESIS
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.0114 |
| p.adjustMANOVA | 0.0348 |
| s.dist | 0.766 |
| s.hyp | -0.0543 |
| s.amy | 0.517 |
| s.hip | -0.198 |
| s.pag | 0.418 |
| s.ni | -0.321 |
| p.hyp | 0.745 |
| p.amy | 0.00194 |
| p.hip | 0.235 |
| p.pag | 0.0121 |
| p.ni | 0.0544 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | pag |
|---|---|---|
| St3gal4 | 7800 | 8138 |
| B3galt2 | 6205 | 8815 |
| B3galt5 | 6259 | 7547 |
| Fut10 | 3790 | 8632 |
| Fut11 | 4460 | 6445 |
| Fut9 | 5004 | 4867 |
| St6galnac6 | 3004 | 7398 |
| B3galt1 | 5061 | 3605 |
| St3gal3 | 1084 | 7895 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| B3galt1 | -1778 | 5061 | -4034 | 3605 | -3659 |
| B3galt2 | -6332 | 6205 | -7064 | 8815 | -6652 |
| B3galt4 | -3962 | -1869 | -1636 | -2013 | -2954 |
| B3galt5 | -1453 | 6259 | 5387 | 7547 | -891 |
| Fut10 | -712 | 3790 | -3256 | 8632 | 2019 |
| Fut11 | -1881 | 4460 | 2909 | 6445 | -1945 |
| Fut2 | -4953 | 2012 | -3127 | -3421 | -3238 |
| Fut9 | 2918 | 5004 | -7121 | 4867 | -7131 |
| St3gal3 | -969 | 1084 | 7425 | 7895 | 129 |
| St3gal4 | 7908 | 7800 | -405 | 8138 | -482 |
| St3gal6 | 1687 | 5152 | -7672 | -6615 | -6130 |
| St6galnac6 | 5519 | 3004 | 933 | 7398 | 6190 |
INCRETIN SYNTHESIS SECRETION AND INACTIVATION
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.00109 |
| p.adjustMANOVA | 0.0054 |
| s.dist | 0.763 |
| s.hyp | 0.288 |
| s.amy | 0.271 |
| s.hip | -0.64 |
| s.pag | -0.0337 |
| s.ni | -0.125 |
| p.hyp | 0.0724 |
| p.amy | 0.0907 |
| p.hip | 6.45e-05 |
| p.pag | 0.833 |
| p.ni | 0.434 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | hyp |
|---|---|---|
| Spcs1 | -6132 | 7108 |
| Spcs2 | -7758 | 4593 |
| Sec11c | -4786 | 5061 |
| Isl1 | -4341 | 5559 |
| Sec11a | -5915 | 2809 |
| Gng13 | -2000 | 5363 |
| Dpp4 | -7317 | 1133 |
| Ctnnb1 | -2365 | 2910 |
| Tcf7l2 | -3518 | 1541 |
| Grp | -4255 | 306 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ctnnb1 | 2910 | -460 | -2365 | 8252 | 5467 |
| Dpp4 | 1133 | -5682 | -7317 | -5566 | -4021 |
| Gng13 | 5363 | 875 | -2000 | -6507 | 1166 |
| Grp | 306 | -4796 | -4255 | -4526 | 1127 |
| Isl1 | 5559 | 7531 | -4341 | 2288 | 7989 |
| Pax6 | -4489 | -3066 | -3080 | 1635 | -6729 |
| Pcsk1 | -58 | 1039 | -5945 | 8532 | 1457 |
| Sec11a | 2809 | 776 | -5915 | 4139 | 3309 |
| Sec11c | 5061 | 6539 | -4786 | -1444 | -4511 |
| Spcs1 | 7108 | 7675 | -6132 | -1456 | -3634 |
| Spcs2 | 4593 | 5233 | -7758 | -940 | -1234 |
| Spcs3 | -950 | 5786 | -7224 | 8019 | -4665 |
| Tcf7l2 | 1541 | 5215 | -3518 | -3431 | -2410 |
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00316 |
| p.adjustMANOVA | 0.0128 |
| s.dist | 0.76 |
| s.hyp | 0.254 |
| s.amy | 0.213 |
| s.hip | -0.647 |
| s.pag | -0.0505 |
| s.ni | -0.215 |
| p.hyp | 0.127 |
| p.amy | 0.201 |
| p.hip | 0.000105 |
| p.pag | 0.762 |
| p.ni | 0.198 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | hyp |
|---|---|---|
| Spcs1 | -6132 | 7108 |
| Spcs2 | -7758 | 4593 |
| Sec11c | -4786 | 5061 |
| Sec11a | -5915 | 2809 |
| Gng13 | -2000 | 5363 |
| Dpp4 | -7317 | 1133 |
| Ctnnb1 | -2365 | 2910 |
| Tcf7l2 | -3518 | 1541 |
| Grp | -4255 | 306 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ctnnb1 | 2910 | -460 | -2365 | 8252 | 5467 |
| Dpp4 | 1133 | -5682 | -7317 | -5566 | -4021 |
| Gng13 | 5363 | 875 | -2000 | -6507 | 1166 |
| Grp | 306 | -4796 | -4255 | -4526 | 1127 |
| Pax6 | -4489 | -3066 | -3080 | 1635 | -6729 |
| Pcsk1 | -58 | 1039 | -5945 | 8532 | 1457 |
| Sec11a | 2809 | 776 | -5915 | 4139 | 3309 |
| Sec11c | 5061 | 6539 | -4786 | -1444 | -4511 |
| Spcs1 | 7108 | 7675 | -6132 | -1456 | -3634 |
| Spcs2 | 4593 | 5233 | -7758 | -940 | -1234 |
| Spcs3 | -950 | 5786 | -7224 | 8019 | -4665 |
| Tcf7l2 | 1541 | 5215 | -3518 | -3431 | -2410 |
RHOBTB3 ATPASE CYCLE
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0315 |
| p.adjustMANOVA | 0.0777 |
| s.dist | 0.757 |
| s.hyp | -0.0796 |
| s.amy | 0.478 |
| s.hip | -0.321 |
| s.pag | 0.446 |
| s.ni | -0.191 |
| p.hyp | 0.663 |
| p.amy | 0.00888 |
| p.hip | 0.0792 |
| p.pag | 0.0146 |
| p.ni | 0.295 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | pag |
|---|---|---|
| Cul3 | 7164 | 7742 |
| Plin3 | 7579 | 6342 |
| Rhobtb3 | 7215 | 6332 |
| Lrrc41 | 2603 | 7441 |
| Rab9b | 4519 | 4113 |
| Htr7 | 2142 | 8600 |
| Vhl | 5001 | 2398 |
| Hgs | 580 | 5494 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ccne1 | -7293 | -6514 | -669 | -2397 | -3318 |
| Cul3 | -5617 | 7164 | -6982 | 7742 | -7238 |
| Hgs | -5489 | 580 | 5653 | 5494 | 4646 |
| Htr7 | -2048 | 2142 | -1098 | 8600 | 2488 |
| Lrrc41 | -4375 | 2603 | 1242 | 7441 | 4505 |
| Plin3 | 7407 | 7579 | -3035 | 6342 | 6698 |
| Rab9 | 721 | 6615 | -7160 | -1124 | -6440 |
| Rab9b | 506 | 4519 | -1354 | 4113 | -2196 |
| Rhobtb3 | 3731 | 7215 | -6526 | 6332 | -6601 |
| Vhl | 7111 | 5001 | -4497 | 2398 | -2908 |
PROTEIN METHYLATION
| metric | value |
|---|---|
| setSize | 17 |
| pMANOVA | 0.00545 |
| p.adjustMANOVA | 0.0195 |
| s.dist | 0.754 |
| s.hyp | 0.295 |
| s.amy | 0.444 |
| s.hip | -0.466 |
| s.pag | 0.129 |
| s.ni | -0.225 |
| p.hyp | 0.0352 |
| p.amy | 0.00153 |
| p.hip | 0.000869 |
| p.pag | 0.355 |
| p.ni | 0.109 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Calm1 | -7742 | 5299 |
| Vcp | -5893 | 6849 |
| Hspa8 | -7399 | 5109 |
| Kin | -6722 | 5457 |
| Eef1a1 | -5328 | 6783 |
| Eef1akmt2 | -6769 | 3608 |
| Eef1akmt1 | -4367 | 4677 |
| Camkmt | -2549 | 5484 |
| Rps2 | -7251 | 1347 |
| Etfb | -4960 | 1903 |
| Mettl21a | -1747 | 3417 |
| Eef2 | -692 | 5018 |
| Vcpkmt | -6719 | 169 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Calm1 | 1411 | 5299 | -7742 | -2751 | -6837 |
| Camkmt | -6873 | 5484 | -2549 | 8420 | -2310 |
| Eef1a1 | 5841 | 6783 | -5328 | 5851 | 3479 |
| Eef1akmt1 | 4078 | 4677 | -4367 | 1361 | -4696 |
| Eef1akmt2 | 6238 | 3608 | -6769 | 6847 | 906 |
| Eef2 | 4311 | 5018 | -692 | 5850 | 6536 |
| Eef2kmt | 5952 | -2161 | 2129 | -4273 | 1132 |
| Etfb | 5300 | 1903 | -4960 | -4885 | 845 |
| Etfbkmt | 2970 | -934 | -4837 | 5605 | 1990 |
| Hspa8 | -4011 | 5109 | -7399 | 952 | -5664 |
| Kin | -3922 | 5457 | -6722 | -5724 | -6135 |
| Mettl21a | 3071 | 3417 | -1747 | 6642 | 2459 |
| Mettl22 | 5459 | 1242 | 4965 | 7072 | -2541 |
| Prmt3 | 1356 | 4859 | 4741 | 2388 | -4510 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Vcp | 2535 | 6849 | -5893 | 4204 | 2960 |
| Vcpkmt | 5650 | 169 | -6719 | -33 | -6708 |
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION
| metric | value |
|---|---|
| setSize | 31 |
| pMANOVA | 7.72e-06 |
| p.adjustMANOVA | 7.23e-05 |
| s.dist | 0.747 |
| s.hyp | 0.223 |
| s.amy | 0.303 |
| s.hip | -0.549 |
| s.pag | -0.083 |
| s.ni | -0.329 |
| p.hyp | 0.0319 |
| p.amy | 0.00348 |
| p.hip | 1.19e-07 |
| p.pag | 0.424 |
| p.ni | 0.00154 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | ni |
|---|---|---|
| Cdc42 | -7712 | -7011 |
| Tcp1 | -7732 | -6097 |
| Hnrnpdl | -7404 | -6324 |
| Mtap | -6319 | -6891 |
| Rap1b | -7352 | -5668 |
| Ppia | -7327 | -5255 |
| Rala | -6924 | -5243 |
| Lcp1 | -5395 | -6703 |
| Capza1 | -5350 | -6346 |
| Hnrnpa2b1 | -6868 | -4749 |
| Hspa9 | -6951 | -2332 |
| Taldo1 | -3496 | -4375 |
| Cfl1 | -2773 | -4819 |
| Gsto1 | -5108 | -2261 |
| Snrpa1 | -4803 | -2398 |
| Psme2 | -6092 | -1590 |
| Pdcd4 | -6486 | -1304 |
| Pitpna | -1562 | -5074 |
| Aip | -2408 | -1712 |
| Arf1 | -519 | -3483 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Aip | 1383 | -4376 | -2408 | 428 | -1712 |
| Anxa2 | 6858 | 908 | 463 | -493 | 5077 |
| Arf1 | 1958 | 4498 | -519 | 4567 | -3483 |
| Bola2 | 7023 | -1847 | -8 | -3807 | 965 |
| Capza1 | -5516 | 4771 | -5350 | 3916 | -6346 |
| Cdc42 | 3468 | 6100 | -7712 | 4029 | -7011 |
| Cfl1 | 267 | 2234 | -2773 | 802 | -4819 |
| Cnn2 | 3698 | 5607 | -4626 | -4968 | 2046 |
| Gsto1 | 7059 | 6847 | -5108 | 2520 | -2261 |
| Hnrnpa2b1 | -1269 | -5294 | -6868 | -2055 | -4749 |
| Hnrnpdl | -7124 | -5621 | -7404 | -4073 | -6324 |
| Hnrnpf | 6511 | 264 | -4302 | 7946 | 6588 |
| Hspa9 | -4745 | 4260 | -6951 | 3401 | -2332 |
| Lcp1 | -5434 | 2573 | -5395 | -6274 | -6703 |
| Lmnb1 | -3673 | -7598 | 1336 | 3410 | 5181 |
| Mif | 4000 | 529 | 3675 | -4791 | -729 |
| Msn | 7689 | 6652 | -1159 | -1758 | 3282 |
| Mtap | -5828 | 5195 | -6319 | 4097 | -6891 |
| Pak2 | 1090 | 7647 | -4607 | 8226 | -21 |
| Pdcd4 | 5520 | -1377 | -6486 | -6327 | -1304 |
| Pitpna | -6165 | -5727 | -1562 | 594 | -5074 |
| Ppia | 3802 | 5236 | -7327 | -1038 | -5255 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Rala | -3514 | 2929 | -6924 | 3965 | -5243 |
| Rap1b | 5736 | 6706 | -7352 | 7351 | -5668 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Snrpa1 | 6228 | 4770 | -4803 | -3103 | -2398 |
| Sod1 | 5318 | 5472 | -2952 | -5289 | 1246 |
| Sod2 | 2926 | -196 | -3441 | -6001 | 435 |
| Taldo1 | 5293 | 5303 | -3496 | 3136 | -4375 |
| Tcp1 | 1564 | 7700 | -7732 | 7689 | -6097 |
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00657 |
| p.adjustMANOVA | 0.0224 |
| s.dist | 0.741 |
| s.hyp | 0.0634 |
| s.amy | 0.466 |
| s.hip | -0.523 |
| s.pag | 0.215 |
| s.ni | -0.0853 |
| p.hyp | 0.704 |
| p.amy | 0.00518 |
| p.hip | 0.0017 |
| p.pag | 0.197 |
| p.ni | 0.609 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Pla2g7 | -7667 | 7362 |
| Spcs1 | -6132 | 7675 |
| Spcs3 | -7224 | 5786 |
| Spcs2 | -7758 | 5233 |
| Sec11c | -4786 | 6539 |
| Klf4 | -2132 | 5721 |
| Pcsk1 | -5945 | 1039 |
| Sec11a | -5915 | 776 |
| Bche | -5307 | 585 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Ache | -2145 | 6238 | 4094 | 3948 | 7144 |
| Bche | -2586 | 585 | -5307 | 1167 | -4768 |
| Crhr2 | -1887 | -1507 | 3424 | 1640 | 7327 |
| Igf1 | -6454 | -2287 | -3225 | -4533 | 679 |
| Klf4 | 6588 | 5721 | -2132 | 5766 | 3866 |
| Pcsk1 | -58 | 1039 | -5945 | 8532 | 1457 |
| Pla2g7 | -4898 | 7362 | -7667 | 7144 | -7330 |
| Sec11a | 2809 | 776 | -5915 | 4139 | 3309 |
| Sec11c | 5061 | 6539 | -4786 | -1444 | -4511 |
| Spcs1 | 7108 | 7675 | -6132 | -1456 | -3634 |
| Spcs2 | 4593 | 5233 | -7758 | -940 | -1234 |
| Spcs3 | -950 | 5786 | -7224 | 8019 | -4665 |
METABOLISM OF POLYAMINES
| metric | value |
|---|---|
| setSize | 57 |
| pMANOVA | 3.27e-10 |
| p.adjustMANOVA | 9.02e-09 |
| s.dist | 0.738 |
| s.hyp | 0.354 |
| s.amy | 0.391 |
| s.hip | -0.429 |
| s.pag | 0.0383 |
| s.ni | -0.285 |
| p.hyp | 3.8e-06 |
| p.amy | 3.24e-07 |
| p.hip | 2.09e-08 |
| p.pag | 0.617 |
| p.ni | 2e-04 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Psmc1 | -7755 | 7562 |
| Amd1 | -7576 | 7557 |
| Psmc6 | -7432 | 6646 |
| Psmd1 | -6547 | 7524 |
| Psmb1 | -7079 | 6831 |
| Psmd12 | -7688 | 6210 |
| Psma3 | -7487 | 6045 |
| Psmd8 | -5938 | 7146 |
| Psmc2 | -6312 | 6669 |
| Psma6 | -7560 | 5429 |
| Nqo1 | -5501 | 6953 |
| Psmd6 | -6922 | 5500 |
| Psmd14 | -7043 | 5290 |
| Psmd7 | -6184 | 5672 |
| Psma2 | -6867 | 5063 |
| Psma1 | -6200 | 5569 |
| Psma4 | -6652 | 4583 |
| Sms | -7263 | 3832 |
| Psmb7 | -6834 | 3928 |
| Azin1 | -4247 | 6237 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Agmat | -954 | 4621 | 1812 | -517 | -5646 |
| Amd1 | 1294 | 7557 | -7576 | 5515 | -5128 |
| Azin1 | 6973 | 6237 | -4247 | 8779 | -6226 |
| Azin2 | -3541 | -1868 | 4702 | 5600 | 4941 |
| Nqo1 | 7978 | 6953 | -5501 | 6509 | -1783 |
| Oaz1 | 6522 | -700 | -3667 | 1591 | 1473 |
| Oaz2 | 1971 | 3268 | -6412 | -999 | 4 |
| Oaz3 | -7659 | 2558 | -6582 | -6877 | 7188 |
| Odc1 | 2806 | -834 | -3582 | 5954 | -146 |
| Paox | -4497 | 2309 | -3279 | -555 | -405 |
| Psma1 | 5607 | 5569 | -6200 | 4740 | -6762 |
| Psma2 | 4294 | 5063 | -6867 | 4100 | -6533 |
| Psma3 | 6689 | 6045 | -7487 | -1551 | -2236 |
| Psma4 | 1744 | 4583 | -6652 | -1795 | -5550 |
| Psma5 | 3320 | -1473 | -6615 | 3565 | -4790 |
| Psma6 | 4239 | 5429 | -7560 | 5363 | -5732 |
| Psma7 | 4346 | 2253 | -4971 | -1615 | -2288 |
| Psmb1 | 5425 | 6831 | -7079 | 1873 | -5397 |
| Psmb10 | 5365 | -1177 | -2384 | -3872 | 1032 |
| Psmb2 | 6873 | 4670 | 1134 | -1064 | 289 |
| Psmb3 | 5155 | 748 | -798 | -1634 | -2798 |
| Psmb4 | 5773 | 5075 | -3786 | -2698 | 2437 |
| Psmb5 | 5738 | 551 | 3823 | -5056 | 1805 |
| Psmb6 | 5242 | -395 | -1575 | -982 | -213 |
| Psmb7 | 5788 | 3928 | -6834 | 520 | -5744 |
| Psmb8 | 3416 | 2736 | -6296 | -2898 | 3473 |
| Psmb9 | 840 | -4740 | -2793 | -4567 | 167 |
| Psmc1 | 1281 | 7562 | -7755 | -3569 | -2836 |
| Psmc2 | 399 | 6669 | -6312 | 1437 | -4040 |
| Psmc3 | 5782 | 1161 | -2887 | 2021 | -4413 |
| Psmc4 | 5458 | 8 | 2117 | 455 | 272 |
| Psmc5 | 6183 | 5192 | -4264 | 1969 | -5209 |
| Psmc6 | -4948 | 6646 | -7432 | 8559 | -7419 |
| Psmd1 | -1909 | 7524 | -6547 | -2340 | -251 |
| Psmd10 | 6334 | 1117 | -6728 | 3839 | -5682 |
| Psmd11 | 770 | 979 | 599 | -3449 | -1053 |
| Psmd12 | -7347 | 6210 | -7688 | 6526 | -7219 |
| Psmd13 | 6486 | -1504 | -1320 | 4364 | -2359 |
| Psmd14 | 6263 | 5290 | -7043 | 6717 | -6867 |
| Psmd2 | -866 | -163 | -93 | 7544 | 1305 |
| Psmd3 | 6426 | -50 | 6648 | 4126 | 3080 |
| Psmd4 | 3267 | 645 | 1378 | -3443 | 2189 |
| Psmd5 | -1200 | 4463 | -2977 | 7366 | -2872 |
| Psmd6 | 4797 | 5500 | -6922 | 6782 | -5316 |
| Psmd7 | 5456 | 5672 | -6184 | -1999 | 2849 |
| Psmd8 | 5672 | 7146 | -5938 | 526 | -6055 |
| Psmd9 | 6230 | 3553 | 169 | -2327 | 6271 |
| Psme1 | 4248 | 89 | -2892 | -1726 | 7024 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Psme3 | 3038 | 4952 | -3093 | 1529 | -1447 |
| Psme4 | -2265 | -7768 | 3276 | 1950 | -3256 |
| Psmf1 | -357 | 3223 | 354 | -1461 | -3409 |
| Sat1 | 496 | 1643 | -7515 | 2654 | -5915 |
| Sem1 | 6676 | 1611 | -3003 | -2719 | -2139 |
| Smox | 7826 | 7771 | 7996 | 8796 | 8291 |
| Sms | -6157 | 3832 | -7263 | -64 | -6862 |
| Srm | -1465 | 4336 | 7024 | 6041 | -1487 |
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL
| metric | value |
|---|---|
| setSize | 12 |
| pMANOVA | 0.00436 |
| p.adjustMANOVA | 0.0163 |
| s.dist | 0.738 |
| s.hyp | 0.433 |
| s.amy | 0.443 |
| s.hip | 0.0929 |
| s.pag | 0.355 |
| s.ni | 0.161 |
| p.hyp | 0.00937 |
| p.amy | 0.00782 |
| p.hip | 0.577 |
| p.pag | 0.0333 |
| p.ni | 0.334 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hyp |
|---|---|---|
| Hsd3b7 | 7224 | 7901 |
| Scp2 | 7348 | 6439 |
| Ptgis | 5824 | 7917 |
| Cyp7b1 | 4514 | 7437 |
| Rxra | 6031 | 5013 |
| Slc27a2 | 2480 | 6774 |
| Hsd17b4 | 7110 | 1745 |
| Amacr | 2132 | 2553 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Acot8 | 6151 | -1000 | 2978 | -2563 | 5117 |
| Amacr | 2553 | 2132 | -3078 | 5473 | -4740 |
| Cyp27a1 | -4724 | 4234 | 2722 | -2371 | -3876 |
| Cyp7b1 | 7437 | 4514 | -4659 | 5105 | 418 |
| Hsd17b4 | 1745 | 7110 | -3023 | 8480 | 4136 |
| Hsd3b7 | 7901 | 7224 | 155 | 8622 | 4685 |
| Ncoa1 | -2819 | -2767 | 5129 | -2379 | 2372 |
| Ncoa2 | -2054 | -2127 | 5281 | 1272 | 1664 |
| Ptgis | 7917 | 5824 | 2069 | 5673 | 6564 |
| Rxra | 5013 | 6031 | 5441 | 7066 | 8252 |
| Scp2 | 6439 | 7348 | -6691 | 4015 | -5244 |
| Slc27a2 | 6774 | 2480 | 3684 | 6849 | 1727 |
NEGATIVE REGULATION OF NOTCH4 SIGNALING
| metric | value |
|---|---|
| setSize | 54 |
| pMANOVA | 7.18e-10 |
| p.adjustMANOVA | 1.83e-08 |
| s.dist | 0.736 |
| s.hyp | 0.349 |
| s.amy | 0.373 |
| s.hip | -0.442 |
| s.pag | -0.046 |
| s.ni | -0.291 |
| p.hyp | 9.42e-06 |
| p.amy | 2.14e-06 |
| p.hip | 1.96e-08 |
| p.pag | 0.559 |
| p.ni | 0.000219 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Psmc1 | -7755 | 7562 |
| Skp1 | -7782 | 7447 |
| Psmc6 | -7432 | 6646 |
| Psmd1 | -6547 | 7524 |
| Psmb1 | -7079 | 6831 |
| Psmd12 | -7688 | 6210 |
| Psma3 | -7487 | 6045 |
| Psmd8 | -5938 | 7146 |
| Psmc2 | -6312 | 6669 |
| Psma6 | -7560 | 5429 |
| Psmd6 | -6922 | 5500 |
| Psmd14 | -7043 | 5290 |
| Rps27a | -6007 | 6029 |
| Rbx1 | -6293 | 5615 |
| Psmd7 | -6184 | 5672 |
| Psma2 | -6867 | 5063 |
| Psma1 | -6200 | 5569 |
| Psma4 | -6652 | 4583 |
| Psmb7 | -6834 | 3928 |
| Psmc5 | -4264 | 5192 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Akt1 | -5046 | 1799 | 5344 | 6269 | 3459 |
| Cul1 | -7461 | 1004 | -2558 | 8662 | -6598 |
| Fbxw7 | -1322 | -1588 | -7693 | -5513 | -6505 |
| Notch4 | 5655 | 2566 | 7282 | -2458 | 7873 |
| Psma1 | 5607 | 5569 | -6200 | 4740 | -6762 |
| Psma2 | 4294 | 5063 | -6867 | 4100 | -6533 |
| Psma3 | 6689 | 6045 | -7487 | -1551 | -2236 |
| Psma4 | 1744 | 4583 | -6652 | -1795 | -5550 |
| Psma5 | 3320 | -1473 | -6615 | 3565 | -4790 |
| Psma6 | 4239 | 5429 | -7560 | 5363 | -5732 |
| Psma7 | 4346 | 2253 | -4971 | -1615 | -2288 |
| Psmb1 | 5425 | 6831 | -7079 | 1873 | -5397 |
| Psmb10 | 5365 | -1177 | -2384 | -3872 | 1032 |
| Psmb2 | 6873 | 4670 | 1134 | -1064 | 289 |
| Psmb3 | 5155 | 748 | -798 | -1634 | -2798 |
| Psmb4 | 5773 | 5075 | -3786 | -2698 | 2437 |
| Psmb5 | 5738 | 551 | 3823 | -5056 | 1805 |
| Psmb6 | 5242 | -395 | -1575 | -982 | -213 |
| Psmb7 | 5788 | 3928 | -6834 | 520 | -5744 |
| Psmb8 | 3416 | 2736 | -6296 | -2898 | 3473 |
| Psmb9 | 840 | -4740 | -2793 | -4567 | 167 |
| Psmc1 | 1281 | 7562 | -7755 | -3569 | -2836 |
| Psmc2 | 399 | 6669 | -6312 | 1437 | -4040 |
| Psmc3 | 5782 | 1161 | -2887 | 2021 | -4413 |
| Psmc4 | 5458 | 8 | 2117 | 455 | 272 |
| Psmc5 | 6183 | 5192 | -4264 | 1969 | -5209 |
| Psmc6 | -4948 | 6646 | -7432 | 8559 | -7419 |
| Psmd1 | -1909 | 7524 | -6547 | -2340 | -251 |
| Psmd10 | 6334 | 1117 | -6728 | 3839 | -5682 |
| Psmd11 | 770 | 979 | 599 | -3449 | -1053 |
| Psmd12 | -7347 | 6210 | -7688 | 6526 | -7219 |
| Psmd13 | 6486 | -1504 | -1320 | 4364 | -2359 |
| Psmd14 | 6263 | 5290 | -7043 | 6717 | -6867 |
| Psmd2 | -866 | -163 | -93 | 7544 | 1305 |
| Psmd3 | 6426 | -50 | 6648 | 4126 | 3080 |
| Psmd4 | 3267 | 645 | 1378 | -3443 | 2189 |
| Psmd5 | -1200 | 4463 | -2977 | 7366 | -2872 |
| Psmd6 | 4797 | 5500 | -6922 | 6782 | -5316 |
| Psmd7 | 5456 | 5672 | -6184 | -1999 | 2849 |
| Psmd8 | 5672 | 7146 | -5938 | 526 | -6055 |
| Psmd9 | 6230 | 3553 | 169 | -2327 | 6271 |
| Psme1 | 4248 | 89 | -2892 | -1726 | 7024 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Psme3 | 3038 | 4952 | -3093 | 1529 | -1447 |
| Psmf1 | -357 | 3223 | 354 | -1461 | -3409 |
| Rbx1 | 1679 | 5615 | -6293 | -3312 | -4293 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Sem1 | 6676 | 1611 | -3003 | -2719 | -2139 |
| Skp1 | 1880 | 7447 | -7782 | 3194 | -6886 |
| Tacc3 | -5085 | -7030 | 2122 | 8673 | 1179 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Ubb | 78 | 4257 | -1569 | -1899 | -1838 |
| Ubc | -6658 | -637 | 164 | 5562 | 728 |
| Ywhaz | 725 | -794 | -5732 | -5975 | -2666 |
TRANSLATION
| metric | value |
|---|---|
| setSize | 286 |
| pMANOVA | 5.56e-62 |
| p.adjustMANOVA | 6.46e-59 |
| s.dist | 0.733 |
| s.hyp | 0.416 |
| s.amy | 0.372 |
| s.hip | -0.419 |
| s.pag | -0.116 |
| s.ni | -0.193 |
| p.hyp | 1.12e-33 |
| p.amy | 2.83e-27 |
| p.hip | 3.35e-34 |
| p.pag | 0.000769 |
| p.ni | 2.01e-08 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | hyp |
|---|---|---|
| Eif3j2 | -7680 | 7061 |
| Rpl22l1 | -7616 | 6909 |
| Rpl3 | -6912 | 7452 |
| Rpl27a | -7289 | 6827 |
| Ssr3 | -6804 | 7258 |
| Rps24 | -7078 | 6708 |
| Rpl35a | -7800 | 6017 |
| Sec61g | -6250 | 7493 |
| Rps3a1 | -6741 | 6917 |
| Mrps35 | -6127 | 7589 |
| Rpl30 | -7767 | 5835 |
| Mrps18c | -7291 | 6156 |
| Rplp0 | -7543 | 5927 |
| Mrpl16 | -6604 | 6605 |
| Spcs1 | -6132 | 7108 |
| Rps6 | -6279 | 6941 |
| Mrpl32 | -6616 | 6512 |
| Rps3 | -6125 | 7019 |
| Rps27a | -6007 | 7081 |
| Eif3m | -7481 | 5667 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Aars | -4869 | 3500 | 323 | 5911 | 666 |
| Aars2 | -2719 | -5885 | 7342 | -996 | 3913 |
| Aimp1 | 5817 | 4631 | -7057 | -1374 | -4457 |
| Aimp2 | 7341 | 252 | -422 | 921 | -1134 |
| Apeh | 7822 | 4359 | 3307 | 2560 | 5951 |
| Aurkaip1 | 4611 | 5556 | -4158 | -2250 | -302 |
| Cars | 41 | -1605 | 5306 | -5532 | 936 |
| Cars2 | 2369 | -5222 | 6527 | -3652 | 2726 |
| Chchd1 | 6264 | 4827 | -6372 | -732 | -5475 |
| Dap3 | 5422 | 520 | 3034 | 5017 | 4722 |
| Dars | -5221 | 5074 | -6953 | 6210 | -6615 |
| Dars2 | 3030 | 2712 | -3797 | 8550 | -3073 |
| Ddost | 2688 | 5850 | 178 | -222 | 6349 |
| Ears2 | 1973 | -6665 | 1759 | 8556 | 4624 |
| Eef1a1 | 5841 | 6783 | -5328 | 5851 | 3479 |
| Eef1a2 | -4541 | 6507 | -920 | 6158 | 482 |
| Eef1b2 | 6448 | 5196 | -6301 | 898 | -3560 |
| Eef1d | 6612 | 3276 | -1430 | -1602 | 2645 |
| Eef1e1 | 5265 | 6857 | -7819 | 3031 | -5614 |
| Eef1g | 5280 | 7188 | -7133 | -2018 | -2269 |
| Eef2 | 4311 | 5018 | -692 | 5850 | 6536 |
| Eif1ax | -4858 | 3565 | -6218 | 8683 | -7134 |
| Eif2b1 | -5292 | -2030 | 2328 | 5382 | -4101 |
| Eif2b2 | 1073 | 4300 | 6340 | 2198 | 7043 |
| Eif2b3 | 418 | -1265 | -6346 | -1028 | -5688 |
| Eif2b4 | 5390 | 2862 | 1930 | -4306 | -3768 |
| Eif2b5 | 6016 | 3165 | -2373 | 2009 | -172 |
| Eif2s1 | -2003 | 7090 | -7556 | 8513 | -7288 |
| Eif2s2 | 3573 | 7098 | -7798 | -5067 | -5729 |
| Eif2s3x | 3602 | 7035 | -6154 | 5580 | -3406 |
| Eif3a | -5464 | -4405 | -5546 | -5480 | 7635 |
| Eif3b | 6718 | 1649 | 2789 | -781 | 5675 |
| Eif3c | 379 | 2604 | -2495 | 4506 | 2925 |
| Eif3d | 5186 | 133 | -2159 | -111 | -1035 |
| Eif3e | 5337 | 6630 | -7676 | 5701 | -6208 |
| Eif3f | 7577 | 5502 | -1607 | 232 | 1095 |
| Eif3g | 1910 | 4006 | -4890 | -1946 | -1789 |
| Eif3h | 3906 | 5135 | -6622 | 6092 | -5021 |
| Eif3i | 5030 | 2167 | 259 | 584 | -3995 |
| Eif3j1 | 447 | 327 | -3801 | 1562 | -3312 |
| Eif3j2 | 7061 | 7040 | -7680 | 1109 | -6230 |
| Eif3k | 4693 | -1060 | -2241 | -2251 | 122 |
| Eif3l | 6166 | 3556 | 2180 | 2515 | -2101 |
| Eif3m | 5667 | 6557 | -7481 | 6973 | -6900 |
| Eif4a1 | 7213 | 2118 | -3860 | 8473 | -2900 |
| Eif4a2 | -1907 | 5567 | -7748 | 8454 | -7228 |
| Eif4b | -2518 | 4027 | -5312 | 7202 | 3030 |
| Eif4e | 3459 | 6422 | -7631 | 5585 | -5425 |
| Eif4ebp1 | 4191 | 3036 | -3085 | 6170 | 2111 |
| Eif4g1 | -2092 | -6035 | 3639 | 39 | 6314 |
| Eif4h | -20 | -1019 | 1450 | 1660 | 6194 |
| Eif5 | -3504 | 4695 | -7687 | -4318 | -7378 |
| Eif5b | 922 | 5210 | -7771 | -6787 | 3979 |
| Eprs | -4001 | 821 | -4647 | -527 | 2281 |
| Eral1 | 7642 | 1983 | 7054 | -1828 | 3903 |
| Etf1 | -5023 | 4915 | -6799 | 1359 | -5204 |
| Fars2 | 6473 | -2263 | -2794 | 2111 | 4052 |
| Farsa | 4490 | -7228 | 5839 | -2588 | 7045 |
| Farsb | -4641 | 4417 | -1840 | 1466 | -5369 |
| Fau | 6946 | 5498 | -3001 | -4264 | 2262 |
| Gadd45gip1 | 2719 | -314 | -1319 | -4764 | -2072 |
| Gars | -4895 | 6891 | -6882 | 3918 | -6422 |
| Gfm1 | -3979 | 2933 | -1188 | 3419 | -4260 |
| Gfm2 | 1937 | -6041 | 3375 | 2699 | -2848 |
| Gspt1 | -2197 | 4678 | 1979 | 6292 | -1787 |
| Gspt2 | -4475 | -2821 | 258 | 4156 | -1367 |
| Hars | -458 | 4884 | -5907 | 6419 | -2301 |
| Hars2 | 1579 | -1720 | 1884 | 5932 | 1140 |
| Iars | -7221 | -4947 | 5103 | 7856 | 1949 |
| Iars2 | 872 | 834 | 2879 | 219 | 747 |
| Kars | 950 | 7673 | -3115 | 2957 | -4638 |
| Lars | -4308 | -5633 | -1119 | 6070 | 5759 |
| Lars2 | 7967 | 4778 | 3343 | -6904 | 8134 |
| Mars1 | -2912 | -6189 | 6209 | 7802 | 3193 |
| Mars2 | -186 | -3261 | -2810 | 3836 | 70 |
| Mrpl1 | -7178 | 5783 | -7091 | 3983 | -6755 |
| Mrpl10 | -1128 | 2986 | -4377 | -1158 | -5370 |
| Mrpl11 | 5623 | 3943 | -5694 | -3025 | -4901 |
| Mrpl12 | 5558 | 1587 | -3991 | -1298 | -4224 |
| Mrpl13 | 2854 | 6529 | -6880 | 172 | -4887 |
| Mrpl14 | 6766 | 965 | -621 | -3626 | 1497 |
| Mrpl15 | 4456 | 7743 | -7344 | 3568 | -5360 |
| Mrpl16 | 6605 | 591 | -6604 | 8092 | -6577 |
| Mrpl17 | 4328 | 5406 | -4805 | 2558 | -2569 |
| Mrpl18 | 2426 | 4850 | -5270 | -355 | -6340 |
| Mrpl19 | -1350 | 1193 | -6675 | -3826 | -1800 |
| Mrpl2 | 4076 | 3303 | 690 | -1587 | 996 |
| Mrpl20 | 4100 | -706 | -337 | -3007 | -3120 |
| Mrpl21 | 3578 | 2582 | -2101 | -4464 | -4436 |
| Mrpl22 | -3187 | 4922 | -2252 | 3050 | -6076 |
| Mrpl23 | 7764 | 926 | -4395 | -4346 | -180 |
| Mrpl24 | 5256 | 4553 | -4499 | -3876 | -625 |
| Mrpl27 | 3425 | -2044 | -2424 | -3073 | -3270 |
| Mrpl28 | 5329 | 4608 | -1730 | -3885 | -2166 |
| Mrpl3 | 1819 | -797 | -4430 | 5608 | -6751 |
| Mrpl30 | 2374 | 6913 | -5617 | -771 | -4225 |
| Mrpl32 | 6512 | 6672 | -6616 | 2589 | -6808 |
| Mrpl33 | 4617 | 4413 | -6852 | -4555 | -3786 |
| Mrpl34 | 5230 | 7082 | -6327 | 318 | -5040 |
| Mrpl35 | 6295 | 3588 | -5854 | 2455 | -5251 |
| Mrpl36 | 6195 | 355 | -1090 | 525 | -4105 |
| Mrpl37 | 5532 | -1016 | 5131 | 6906 | -3080 |
| Mrpl38 | 234 | 960 | 2803 | -706 | 3774 |
| Mrpl39 | -775 | 4604 | -5900 | 1226 | -4144 |
| Mrpl4 | 5367 | -1136 | 6687 | 743 | -1214 |
| Mrpl40 | 654 | 3610 | -5046 | -183 | -6023 |
| Mrpl41 | 5151 | 2195 | -2580 | -2536 | -471 |
| Mrpl42 | 4374 | 6563 | -5765 | -1981 | -6768 |
| Mrpl43 | 5125 | 3935 | -4195 | -1598 | -3610 |
| Mrpl44 | -3001 | 4165 | -3911 | -2584 | -1920 |
| Mrpl46 | 5011 | 2591 | -2727 | -1258 | -4210 |
| Mrpl47 | 6599 | 6552 | -6360 | 350 | -7021 |
| Mrpl48 | 4330 | 7384 | -7128 | -5139 | -4342 |
| Mrpl49 | 502 | 1746 | -3362 | 3399 | -3180 |
| Mrpl50 | 960 | 5194 | -7619 | 2546 | -6395 |
| Mrpl51 | 7705 | 5527 | -3026 | -5198 | -4232 |
| Mrpl52 | 6884 | 3947 | -1776 | -2919 | -897 |
| Mrpl53 | 5844 | -1840 | 239 | -2804 | -1608 |
| Mrpl54 | 4382 | 6379 | -5931 | -4562 | -2637 |
| Mrpl55 | -4624 | -978 | -564 | -5392 | -1687 |
| Mrpl57 | 4421 | 1933 | 823 | -4634 | -1422 |
| Mrpl58 | 1874 | -766 | 1779 | -2467 | -723 |
| Mrpl9 | 7160 | -3583 | -3015 | 2967 | -1532 |
| Mrps10 | 215 | 6504 | -5895 | -4119 | -2964 |
| Mrps11 | 2034 | -159 | 1667 | -561 | -1266 |
| Mrps12 | 587 | -103 | -673 | -3985 | -3418 |
| Mrps14 | 4293 | 4594 | -5435 | -71 | -5446 |
| Mrps15 | 5880 | 6004 | -631 | -595 | -388 |
| Mrps16 | 4560 | 1621 | -3780 | -669 | -755 |
| Mrps17 | 5913 | 45 | -2768 | -3133 | -496 |
| Mrps18a | 738 | 4318 | -3884 | -2801 | -3967 |
| Mrps18b | 1743 | 900 | -4177 | -4600 | -3320 |
| Mrps18c | 6156 | 3946 | -7291 | -2160 | -3895 |
| Mrps2 | -679 | 6952 | -5195 | -5968 | -6984 |
| Mrps21 | 4226 | 1794 | -2311 | -6158 | -2708 |
| Mrps22 | 1962 | 6321 | -7537 | 4373 | -6544 |
| Mrps23 | 5780 | 2985 | -6806 | -4090 | -5139 |
| Mrps24 | 3531 | 4277 | -2133 | -1323 | -1552 |
| Mrps25 | 1236 | 1177 | -6177 | -2178 | -1114 |
| Mrps26 | 3476 | -1196 | -227 | -2826 | 883 |
| Mrps27 | 4176 | -1009 | 3551 | -1848 | -3926 |
| Mrps28 | 416 | -534 | -3742 | 2382 | -134 |
| Mrps30 | 5314 | 5326 | -7472 | 7828 | -6715 |
| Mrps31 | -6680 | 7791 | -7582 | 8342 | -6182 |
| Mrps33 | 4152 | 4822 | -5210 | -3517 | -4042 |
| Mrps34 | 3686 | -2321 | 1713 | -4718 | 1723 |
| Mrps35 | 7589 | 3518 | -6127 | 550 | -3981 |
| Mrps36 | 105 | 7223 | -6964 | -949 | -4574 |
| Mrps5 | -6447 | 4310 | -6130 | -2534 | 1182 |
| Mrps6 | 7256 | 3068 | -3407 | 2688 | 879 |
| Mrps7 | 4784 | 3071 | -4768 | 673 | -2043 |
| Mrps9 | 6322 | 2199 | -3783 | -1118 | -2721 |
| Mrrf | -1481 | 2372 | -1183 | 5134 | -6127 |
| Mtfmt | 2567 | 2832 | 1541 | -5836 | 595 |
| Mtif2 | 48 | -3943 | -4337 | 4826 | -7026 |
| Mtif3 | -4101 | 403 | -5727 | -1994 | -240 |
| Mtrf1l | 2219 | -622 | -4685 | 5295 | 5810 |
| N6amt1 | -1258 | -5602 | -7785 | -6794 | -3377 |
| Nars | -1697 | 4076 | -7466 | 720 | -6112 |
| Nars2 | 3 | 3785 | 14 | 7543 | -4475 |
| Oxa1l | 3524 | 5316 | 5552 | -1536 | -2315 |
| Pabpc1 | 5165 | 6207 | -6818 | -150 | 1038 |
| Pars2 | 3733 | -117 | 1387 | -752 | 6886 |
| Ppa1 | 3976 | 6359 | -7747 | 288 | -6841 |
| Ppa2 | 2310 | 4221 | -6537 | 3691 | -6647 |
| Ptcd3 | -7510 | 3652 | -7024 | 6757 | -7248 |
| Qars | 6731 | 1265 | 5830 | 8728 | 4236 |
| Rars | -2964 | 1416 | -7152 | 1903 | -4214 |
| Rars2 | -1912 | -6541 | -3739 | 1926 | 1773 |
| Rpl10 | 5452 | -3511 | 468 | 8620 | 7196 |
| Rpl10a | 5664 | 689 | -4423 | -6298 | 5663 |
| Rpl11 | 5347 | 5067 | -5841 | 1152 | -414 |
| Rpl12 | 4559 | -7050 | 864 | -4856 | 1444 |
| Rpl13 | 6713 | 3082 | -1790 | 702 | 3578 |
| Rpl13a | 6978 | 5869 | -6057 | -2568 | 1551 |
| Rpl14 | 6153 | 5291 | -5789 | -2393 | -1458 |
| Rpl15 | 5109 | 2876 | -6640 | -3809 | -869 |
| Rpl17 | 5894 | 5356 | -6054 | 315 | -3728 |
| Rpl18 | 6357 | 247 | -2697 | -1047 | -741 |
| Rpl18a | 6732 | 5117 | -5103 | -1206 | 821 |
| Rpl19 | 6400 | 3400 | -3399 | -1734 | 49 |
| Rpl21 | 5967 | 2547 | -4617 | 6067 | -5094 |
| Rpl22 | 5187 | 5626 | -5697 | 1684 | -3687 |
| Rpl22l1 | 6909 | 6666 | -7616 | -1467 | -4410 |
| Rpl23 | 6428 | 6253 | -5012 | -4035 | 281 |
| Rpl23a | 6099 | 7280 | -5116 | 228 | -2552 |
| Rpl24 | 5486 | 7251 | -6234 | -3348 | -3969 |
| Rpl26 | 5084 | 3462 | -7016 | -4428 | 4099 |
| Rpl27 | 6543 | 4979 | -4602 | -2574 | 3444 |
| Rpl27a | 6827 | 2652 | -7289 | -1354 | 291 |
| Rpl28 | 3879 | 790 | -3620 | -5524 | 3938 |
| Rpl29 | 4488 | 3489 | -7077 | -4817 | 483 |
| Rpl3 | 7452 | 5682 | -6912 | -6590 | 2424 |
| Rpl30 | 5835 | 4967 | -7767 | -3474 | 2226 |
| Rpl31 | 6275 | 5445 | -4772 | -5951 | 4211 |
| Rpl32 | 6367 | 4415 | -3350 | -3613 | 693 |
| Rpl34 | 6549 | 3347 | -2765 | -634 | -1305 |
| Rpl35 | 7153 | 4069 | -1706 | -3647 | 1717 |
| Rpl35a | 6017 | 5244 | -7800 | -2633 | 2093 |
| Rpl36 | 7134 | -360 | -150 | -2663 | -103 |
| Rpl36a | 5903 | 3849 | -7110 | -3074 | 888 |
| Rpl36al | 6601 | 1722 | -4533 | -3168 | -3707 |
| Rpl37 | 6385 | 2812 | 136 | -3791 | 2625 |
| Rpl37a | 6863 | 5934 | -2841 | -5373 | 2167 |
| Rpl38 | 7297 | 3811 | 1184 | -5897 | 2991 |
| Rpl39 | 7597 | 4652 | -2511 | -589 | -691 |
| Rpl4 | 5755 | 5892 | -5751 | 1569 | -2602 |
| Rpl5 | 5400 | 5785 | -7518 | -6708 | 4133 |
| Rpl6 | 4272 | 6480 | -6485 | -1115 | -2119 |
| Rpl7 | 5698 | 4794 | -6119 | 1551 | -4296 |
| Rpl7a | 4022 | 2176 | -4012 | 2017 | -2081 |
| Rpl8 | 6940 | 2544 | -2412 | -2513 | 438 |
| Rpl9 | 6697 | 4911 | -6266 | 1209 | -366 |
| Rplp0 | 5927 | 5639 | -7543 | -1113 | -209 |
| Rplp1 | 7126 | -527 | -2470 | -3081 | 2320 |
| Rplp2 | 7150 | 735 | -392 | -3098 | 909 |
| Rpn1 | 3181 | 2470 | -3846 | 5558 | 205 |
| Rpn2 | 5171 | 3111 | -226 | 1699 | 5261 |
| Rps10 | 6733 | 1046 | -3964 | -573 | -737 |
| Rps11 | 5426 | 3351 | -4157 | -1915 | -9 |
| Rps12 | 6717 | -503 | -1668 | -1219 | 3083 |
| Rps13 | 6657 | 2049 | -5583 | -3253 | 2043 |
| Rps14 | 6673 | -1346 | -5672 | -3045 | 2037 |
| Rps15 | 6536 | 647 | -2023 | -3379 | 1025 |
| Rps15a | 5999 | -349 | -3091 | 2258 | -571 |
| Rps16 | 6661 | 1809 | -4770 | -5146 | -316 |
| Rps17 | 6229 | 2599 | -3524 | -1304 | -95 |
| Rps18 | 4183 | 5256 | -7830 | 1768 | -2582 |
| Rps19 | 7296 | 5096 | -4361 | -3135 | 468 |
| Rps2 | 1984 | 1347 | -7251 | -3789 | -2991 |
| Rps20 | 7419 | 5185 | -4679 | -3202 | 278 |
| Rps21 | 7549 | 3040 | -1313 | -2611 | 1590 |
| Rps23 | 6623 | 6538 | -6052 | -4249 | 2973 |
| Rps24 | 6708 | 6131 | -7078 | -610 | -3722 |
| Rps25 | 5860 | 7566 | -5277 | -2169 | -1110 |
| Rps26 | 5292 | 5003 | -3541 | -3077 | 352 |
| Rps27 | 7345 | 2095 | -3333 | -2879 | 789 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Rps27l | 6485 | 7190 | -5513 | -556 | -522 |
| Rps28 | 7315 | 3711 | 2211 | -5637 | 3286 |
| Rps29 | 7692 | 5549 | 3674 | -6435 | 6007 |
| Rps3 | 7019 | 1312 | -6125 | 3717 | 897 |
| Rps3a1 | 6917 | 6809 | -6741 | 1310 | -4090 |
| Rps4x | 6042 | 6448 | -6597 | -736 | -3787 |
| Rps5 | 6900 | 4726 | -2795 | -1890 | 990 |
| Rps6 | 6941 | 1946 | -6279 | 2694 | -2540 |
| Rps7 | 3046 | 6043 | -7818 | -720 | -2249 |
| Rps8 | 6896 | 7065 | -6090 | -3416 | 2664 |
| Rps9 | 7029 | 7338 | -4931 | -3397 | 2222 |
| Rpsa | 7236 | 2967 | -4188 | -1679 | 1042 |
| Sars | -7518 | 102 | -6684 | 1263 | -3619 |
| Sars2 | -3202 | 1232 | 5769 | -172 | 4628 |
| Sec11a | 2809 | 776 | -5915 | 4139 | 3309 |
| Sec11c | 5061 | 6539 | -4786 | -1444 | -4511 |
| Sec61a1 | 471 | -5145 | 6810 | -1055 | 6419 |
| Sec61a2 | -5126 | -5801 | 1624 | 2244 | 2521 |
| Sec61b | 7049 | 1997 | -2692 | -267 | 3838 |
| Sec61g | 7493 | 3077 | -6250 | 1215 | -3192 |
| Spcs1 | 7108 | 7675 | -6132 | -1456 | -3634 |
| Spcs2 | 4593 | 5233 | -7758 | -940 | -1234 |
| Spcs3 | -950 | 5786 | -7224 | 8019 | -4665 |
| Srp14 | 2490 | 3653 | -6223 | -2174 | -1928 |
| Srp19 | 5501 | 3921 | -7093 | -2045 | -5225 |
| Srp54a | 2370 | 6776 | -7360 | -583 | -3682 |
| Srp68 | 146 | -924 | 5591 | 8778 | 5105 |
| Srp72 | -1718 | 6980 | -2498 | 1964 | 18 |
| Srp9 | 3900 | 5401 | -5596 | 1838 | -5694 |
| Srpr | 57 | 6313 | 2479 | 7734 | -275 |
| Srprb | -3531 | 5220 | 123 | 4085 | 5974 |
| Ssr1 | -1008 | 4809 | -6662 | 3819 | -2277 |
| Ssr2 | 4502 | 3864 | -2249 | 4457 | -1371 |
| Ssr3 | 7258 | 7300 | -6804 | 7907 | -4378 |
| Ssr4 | 6055 | -77 | -2472 | -2165 | 869 |
| Tars | -2271 | 3353 | 233 | -785 | -6286 |
| Tars2 | 3352 | -4637 | 2437 | -2504 | 699 |
| Tram1 | 6285 | 2413 | -2959 | 6418 | -2138 |
| Trmt112 | 2647 | -1538 | -5539 | -6491 | 4484 |
| Tsfm | 2540 | 1880 | -5035 | -5900 | -765 |
| Tufm | 4153 | 3962 | 1136 | -2235 | 538 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Vars | 3358 | -6440 | 5928 | -5544 | 4942 |
| Vars2 | 1929 | -6605 | 7196 | 4429 | 5193 |
| Wars | -3579 | 840 | 4106 | 6357 | -78 |
| Wars2 | -3883 | -84 | 3868 | 5154 | 423 |
| Yars | -4293 | 5757 | -2797 | 4575 | -3049 |
| Yars2 | 5777 | -589 | -2949 | 7474 | -2480 |
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
| metric | value |
|---|---|
| setSize | 53 |
| pMANOVA | 7.28e-10 |
| p.adjustMANOVA | 1.83e-08 |
| s.dist | 0.73 |
| s.hyp | 0.366 |
| s.amy | 0.357 |
| s.hip | -0.434 |
| s.pag | -0.0853 |
| s.ni | -0.274 |
| p.hyp | 4.1e-06 |
| p.amy | 6.84e-06 |
| p.hip | 4.63e-08 |
| p.pag | 0.283 |
| p.ni | 0.000557 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | hyp |
|---|---|---|
| Psma3 | -7487 | 6689 |
| Psme2 | -6092 | 7551 |
| Psmd14 | -7043 | 6263 |
| Psmd10 | -6728 | 6334 |
| Rps27a | -6007 | 7081 |
| Psmb7 | -6834 | 5788 |
| Psmb1 | -7079 | 5425 |
| Pabpc1 | -6818 | 5165 |
| Psma1 | -6200 | 5607 |
| Psmd7 | -6184 | 5456 |
| Psmd8 | -5938 | 5672 |
| Psmd6 | -6922 | 4797 |
| Psma6 | -7560 | 4239 |
| Psma2 | -6867 | 4294 |
| Psmc5 | -4264 | 6183 |
| Uba52 | -3631 | 6847 |
| Psma5 | -6615 | 3320 |
| Psmb4 | -3786 | 5773 |
| Psma7 | -4971 | 4346 |
| Psmb8 | -6296 | 3416 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Eif4g1 | -2092 | -6035 | 3639 | 39 | 6314 |
| Hnrnpd | -1175 | 1712 | -6808 | -6145 | 2487 |
| Hspa1a | -7589 | -4972 | 920 | -6129 | -3821 |
| Hspa8 | -4011 | 5109 | -7399 | 952 | -5664 |
| Hspb1 | 7377 | 5380 | 4524 | 1943 | -2752 |
| Pabpc1 | 5165 | 6207 | -6818 | -150 | 1038 |
| Psma1 | 5607 | 5569 | -6200 | 4740 | -6762 |
| Psma2 | 4294 | 5063 | -6867 | 4100 | -6533 |
| Psma3 | 6689 | 6045 | -7487 | -1551 | -2236 |
| Psma4 | 1744 | 4583 | -6652 | -1795 | -5550 |
| Psma5 | 3320 | -1473 | -6615 | 3565 | -4790 |
| Psma6 | 4239 | 5429 | -7560 | 5363 | -5732 |
| Psma7 | 4346 | 2253 | -4971 | -1615 | -2288 |
| Psmb1 | 5425 | 6831 | -7079 | 1873 | -5397 |
| Psmb10 | 5365 | -1177 | -2384 | -3872 | 1032 |
| Psmb2 | 6873 | 4670 | 1134 | -1064 | 289 |
| Psmb3 | 5155 | 748 | -798 | -1634 | -2798 |
| Psmb4 | 5773 | 5075 | -3786 | -2698 | 2437 |
| Psmb5 | 5738 | 551 | 3823 | -5056 | 1805 |
| Psmb6 | 5242 | -395 | -1575 | -982 | -213 |
| Psmb7 | 5788 | 3928 | -6834 | 520 | -5744 |
| Psmb8 | 3416 | 2736 | -6296 | -2898 | 3473 |
| Psmb9 | 840 | -4740 | -2793 | -4567 | 167 |
| Psmc1 | 1281 | 7562 | -7755 | -3569 | -2836 |
| Psmc2 | 399 | 6669 | -6312 | 1437 | -4040 |
| Psmc3 | 5782 | 1161 | -2887 | 2021 | -4413 |
| Psmc4 | 5458 | 8 | 2117 | 455 | 272 |
| Psmc5 | 6183 | 5192 | -4264 | 1969 | -5209 |
| Psmc6 | -4948 | 6646 | -7432 | 8559 | -7419 |
| Psmd1 | -1909 | 7524 | -6547 | -2340 | -251 |
| Psmd10 | 6334 | 1117 | -6728 | 3839 | -5682 |
| Psmd11 | 770 | 979 | 599 | -3449 | -1053 |
| Psmd12 | -7347 | 6210 | -7688 | 6526 | -7219 |
| Psmd13 | 6486 | -1504 | -1320 | 4364 | -2359 |
| Psmd14 | 6263 | 5290 | -7043 | 6717 | -6867 |
| Psmd2 | -866 | -163 | -93 | 7544 | 1305 |
| Psmd3 | 6426 | -50 | 6648 | 4126 | 3080 |
| Psmd4 | 3267 | 645 | 1378 | -3443 | 2189 |
| Psmd5 | -1200 | 4463 | -2977 | 7366 | -2872 |
| Psmd6 | 4797 | 5500 | -6922 | 6782 | -5316 |
| Psmd7 | 5456 | 5672 | -6184 | -1999 | 2849 |
| Psmd8 | 5672 | 7146 | -5938 | 526 | -6055 |
| Psmd9 | 6230 | 3553 | 169 | -2327 | 6271 |
| Psme1 | 4248 | 89 | -2892 | -1726 | 7024 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Psme3 | 3038 | 4952 | -3093 | 1529 | -1447 |
| Psme4 | -2265 | -7768 | 3276 | 1950 | -3256 |
| Psmf1 | -357 | 3223 | 354 | -1461 | -3409 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Sem1 | 6676 | 1611 | -3003 | -2719 | -2139 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Ubb | 78 | 4257 | -1569 | -1899 | -1838 |
| Ubc | -6658 | -637 | 164 | 5562 | 728 |
PHASE 2 PLATEAU PHASE
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0253 |
| p.adjustMANOVA | 0.0656 |
| s.dist | 0.726 |
| s.hyp | -0.163 |
| s.amy | -0.0954 |
| s.hip | 0.396 |
| s.pag | -0.0682 |
| s.ni | 0.574 |
| p.hyp | 0.373 |
| p.amy | 0.602 |
| p.hip | 0.03 |
| p.pag | 0.709 |
| p.ni | 0.00166 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | ni | hip |
|---|---|---|
| Cacng8 | 7513 | 7554 |
| Cacna1c | 6273 | 6741 |
| Cacnb1 | 6148 | 6228 |
| Cacng4 | 8306 | 2975 |
| Akap9 | 7366 | 2314 |
| Cacng7 | 2539 | 5540 |
| Cacna2d2 | 3045 | 4151 |
| Cacnb2 | 307 | 3775 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Akap9 | -1069 | -5045 | 2314 | 665 | 7366 |
| Cacna1c | 249 | -7361 | 6741 | 975 | 6273 |
| Cacna2d2 | -2409 | 564 | 4151 | -2288 | 3045 |
| Cacnb1 | -6451 | -1073 | 6228 | 1398 | 6148 |
| Cacnb2 | -6294 | -2252 | 3775 | 436 | 307 |
| Cacng4 | -2369 | 5655 | 2975 | -5980 | 8306 |
| Cacng7 | -6541 | -2389 | 5540 | 1265 | 2539 |
| Cacng8 | -2086 | -6808 | 7554 | -5940 | 7513 |
| Kcne1l | 7131 | 7697 | -4203 | 6937 | 952 |
| Kcne4 | 7918 | 2496 | -2696 | 6718 | 7839 |
APOPTOSIS INDUCED DNA FRAGMENTATION
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0318 |
| p.adjustMANOVA | 0.0781 |
| s.dist | 0.716 |
| s.hyp | -0.236 |
| s.amy | 0.00964 |
| s.hip | -0.477 |
| s.pag | -0.29 |
| s.ni | -0.383 |
| p.hyp | 0.196 |
| p.amy | 0.958 |
| p.hip | 0.00907 |
| p.pag | 0.113 |
| p.ni | 0.0362 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | ni |
|---|---|---|
| H1f0 | -7650 | -6884 |
| Hmgb1 | -7700 | -5133 |
| Kpna1 | -5018 | -6057 |
| H1f2 | -7814 | -3537 |
| Hmgb2 | -7359 | -3450 |
| Casp3 | -7733 | -1152 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Casp3 | -1290 | -577 | -7733 | 1744 | -1152 |
| Dffa | -5800 | -6004 | 5515 | -2594 | -3084 |
| Dffb | -4128 | -6156 | 5231 | -4438 | -3243 |
| H1f0 | -7810 | -5608 | -7650 | -6454 | -6884 |
| H1f2 | -2593 | 1081 | -7814 | -6211 | -3537 |
| H1f4 | -2340 | 3953 | -5359 | 3554 | 3098 |
| Hmgb1 | 5406 | 6613 | -7700 | -3480 | -5133 |
| Hmgb2 | 2988 | -3470 | -7359 | -5025 | -3450 |
| Kpna1 | 1019 | 7522 | -5018 | 4279 | -6057 |
| Kpnb1 | -3209 | 2450 | 1110 | 5259 | 3916 |
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS
| metric | value |
|---|---|
| setSize | 58 |
| pMANOVA | 3.21e-10 |
| p.adjustMANOVA | 9.02e-09 |
| s.dist | 0.716 |
| s.hyp | 0.349 |
| s.amy | 0.389 |
| s.hip | -0.443 |
| s.pag | 0.0486 |
| s.ni | -0.204 |
| p.hyp | 4.18e-06 |
| p.amy | 3.09e-07 |
| p.hip | 5.43e-09 |
| p.pag | 0.522 |
| p.ni | 0.0072 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | amy |
|---|---|---|
| Psmc1 | -7755 | 7562 |
| Psmc6 | -7432 | 6646 |
| Psmd1 | -6547 | 7524 |
| Psmb1 | -7079 | 6831 |
| Psmd12 | -7688 | 6210 |
| Erlec1 | -7594 | 5978 |
| Psma3 | -7487 | 6045 |
| Psmd8 | -5938 | 7146 |
| Psmc2 | -6312 | 6669 |
| Psma6 | -7560 | 5429 |
| Vcp | -5893 | 6849 |
| Psmd6 | -6922 | 5500 |
| Psmd14 | -7043 | 5290 |
| Rps27a | -6007 | 6029 |
| Psmd7 | -6184 | 5672 |
| Psma2 | -6867 | 5063 |
| Psma1 | -6200 | 5569 |
| Psma4 | -6652 | 4583 |
| Psmb7 | -6834 | 3928 |
| Rnf5 | -6000 | 4470 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Derl1 | 3934 | 3710 | -4094 | 7989 | 1875 |
| Derl2 | 7719 | 879 | -7329 | 8760 | 155 |
| Derl3 | -2739 | 5321 | -1251 | 7759 | 2393 |
| Erlec1 | 4850 | 5978 | -7594 | 2781 | -5642 |
| Erlin1 | -1804 | -2920 | -2374 | 2846 | 597 |
| Erlin2 | -3881 | 1580 | 2791 | 3975 | 6778 |
| Os9 | 2975 | -179 | -1626 | 7305 | 7489 |
| Psma1 | 5607 | 5569 | -6200 | 4740 | -6762 |
| Psma2 | 4294 | 5063 | -6867 | 4100 | -6533 |
| Psma3 | 6689 | 6045 | -7487 | -1551 | -2236 |
| Psma4 | 1744 | 4583 | -6652 | -1795 | -5550 |
| Psma5 | 3320 | -1473 | -6615 | 3565 | -4790 |
| Psma6 | 4239 | 5429 | -7560 | 5363 | -5732 |
| Psma7 | 4346 | 2253 | -4971 | -1615 | -2288 |
| Psmb1 | 5425 | 6831 | -7079 | 1873 | -5397 |
| Psmb10 | 5365 | -1177 | -2384 | -3872 | 1032 |
| Psmb2 | 6873 | 4670 | 1134 | -1064 | 289 |
| Psmb3 | 5155 | 748 | -798 | -1634 | -2798 |
| Psmb4 | 5773 | 5075 | -3786 | -2698 | 2437 |
| Psmb5 | 5738 | 551 | 3823 | -5056 | 1805 |
| Psmb6 | 5242 | -395 | -1575 | -982 | -213 |
| Psmb7 | 5788 | 3928 | -6834 | 520 | -5744 |
| Psmb8 | 3416 | 2736 | -6296 | -2898 | 3473 |
| Psmb9 | 840 | -4740 | -2793 | -4567 | 167 |
| Psmc1 | 1281 | 7562 | -7755 | -3569 | -2836 |
| Psmc2 | 399 | 6669 | -6312 | 1437 | -4040 |
| Psmc3 | 5782 | 1161 | -2887 | 2021 | -4413 |
| Psmc4 | 5458 | 8 | 2117 | 455 | 272 |
| Psmc5 | 6183 | 5192 | -4264 | 1969 | -5209 |
| Psmc6 | -4948 | 6646 | -7432 | 8559 | -7419 |
| Psmd1 | -1909 | 7524 | -6547 | -2340 | -251 |
| Psmd10 | 6334 | 1117 | -6728 | 3839 | -5682 |
| Psmd11 | 770 | 979 | 599 | -3449 | -1053 |
| Psmd12 | -7347 | 6210 | -7688 | 6526 | -7219 |
| Psmd13 | 6486 | -1504 | -1320 | 4364 | -2359 |
| Psmd14 | 6263 | 5290 | -7043 | 6717 | -6867 |
| Psmd2 | -866 | -163 | -93 | 7544 | 1305 |
| Psmd3 | 6426 | -50 | 6648 | 4126 | 3080 |
| Psmd4 | 3267 | 645 | 1378 | -3443 | 2189 |
| Psmd5 | -1200 | 4463 | -2977 | 7366 | -2872 |
| Psmd6 | 4797 | 5500 | -6922 | 6782 | -5316 |
| Psmd7 | 5456 | 5672 | -6184 | -1999 | 2849 |
| Psmd8 | 5672 | 7146 | -5938 | 526 | -6055 |
| Psmd9 | 6230 | 3553 | 169 | -2327 | 6271 |
| Psme1 | 4248 | 89 | -2892 | -1726 | 7024 |
| Psme2 | 7551 | 1605 | -6092 | -5621 | -1590 |
| Psme3 | 3038 | 4952 | -3093 | 1529 | -1447 |
| Psme4 | -2265 | -7768 | 3276 | 1950 | -3256 |
| Psmf1 | -357 | 3223 | 354 | -1461 | -3409 |
| Rnf185 | -7244 | 5645 | -1629 | 1976 | 1047 |
| Rnf5 | 635 | 4470 | -6000 | 960 | 884 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Sel1l | -1928 | 3976 | 2401 | 4754 | 2772 |
| Sem1 | 6676 | 1611 | -3003 | -2719 | -2139 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Ubb | 78 | 4257 | -1569 | -1899 | -1838 |
| Ubc | -6658 | -637 | 164 | 5562 | 728 |
| Vcp | 2535 | 6849 | -5893 | 4204 | 2960 |
INTERACTION BETWEEN L1 AND ANKYRINS
| metric | value |
|---|---|
| setSize | 27 |
| pMANOVA | 0.000323 |
| p.adjustMANOVA | 0.00186 |
| s.dist | 0.712 |
| s.hyp | -0.291 |
| s.amy | -0.348 |
| s.hip | 0.394 |
| s.pag | -0.12 |
| s.ni | 0.362 |
| p.hyp | 0.00882 |
| p.amy | 0.00173 |
| p.hip | 0.00039 |
| p.pag | 0.28 |
| p.ni | 0.00114 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hip | ni |
|---|---|---|
| Sptbn4 | 7719 | 7346 |
| Scn3b | 7504 | 6790 |
| Nfasc | 7644 | 6507 |
| Kcnq2 | 7020 | 6354 |
| Ank2 | 6882 | 6390 |
| Scn3a | 5563 | 6623 |
| Sptbn2 | 6445 | 5631 |
| Scn5a | 4358 | 7547 |
| Sptb | 6667 | 3954 |
| Scn2b | 3554 | 7184 |
| Kcnq3 | 4388 | 5728 |
| Sptbn1 | 3546 | 6933 |
| Sptan1 | 5424 | 4448 |
| L1cam | 5150 | 4543 |
| Scn8a | 7241 | 796 |
| Ank3 | 3361 | 1573 |
| Scn2a | 522 | 4027 |
| Ank1 | 2994 | 266 |
| Nrcam | 1354 | 453 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Actb | 429 | 1896 | -1069 | -6720 | 1629 |
| Actg1 | -5450 | 5417 | -5545 | -2668 | -4367 |
| Ank1 | -2332 | -4028 | 2994 | 2818 | 266 |
| Ank2 | -210 | -7907 | 6882 | -86 | 6390 |
| Ank3 | -127 | 538 | 3361 | -4769 | 1573 |
| Kcnq2 | -4329 | -4989 | 7020 | 2630 | 6354 |
| Kcnq3 | -1346 | -1937 | 4388 | -4613 | 5728 |
| L1cam | -6003 | -6349 | 5150 | 2273 | 4543 |
| Nfasc | -4991 | -4388 | 7644 | 286 | 6507 |
| Nrcam | -5070 | -6027 | 1354 | 6422 | 453 |
| Scn1a | -2200 | -678 | -77 | 4424 | -4825 |
| Scn1b | -5890 | 539 | 1196 | -1381 | -5081 |
| Scn2a | -1851 | -4877 | 522 | -4255 | 4027 |
| Scn2b | -3366 | -3790 | 3554 | -2254 | 7184 |
| Scn3a | -812 | -2337 | 5563 | -4728 | 6623 |
| Scn3b | -7016 | -3147 | 7504 | 81 | 6790 |
| Scn4b | -3480 | 3213 | 1528 | 1525 | -4124 |
| Scn5a | -4368 | -1961 | 4358 | -4736 | 7547 |
| Scn7a | 3999 | -549 | -3449 | 1630 | 4463 |
| Scn8a | -3254 | -7040 | 7241 | -4925 | 796 |
| Scn9a | 5423 | -6264 | -504 | -6019 | 2254 |
| Sptan1 | -4418 | -6816 | 5424 | 6263 | 4448 |
| Sptb | -5039 | 716 | 6667 | 5416 | 3954 |
| Sptbn1 | 35 | -4655 | 3546 | 5268 | 6933 |
| Sptbn2 | -2264 | -1447 | 6445 | 5447 | 5631 |
| Sptbn4 | -488 | -5715 | 7719 | 1385 | 7346 |
| Sptbn5 | 4771 | -4447 | -2485 | 1526 | 7199 |
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
| metric | value |
|---|---|
| setSize | 10 |
| pMANOVA | 0.0139 |
| p.adjustMANOVA | 0.0406 |
| s.dist | 0.709 |
| s.hyp | -0.554 |
| s.amy | -0.246 |
| s.hip | -0.0696 |
| s.pag | 0.155 |
| s.ni | -0.327 |
| p.hyp | 0.00243 |
| p.amy | 0.177 |
| p.hip | 0.703 |
| p.pag | 0.395 |
| p.ni | 0.0737 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | ni |
|---|---|---|
| Fos | -7377 | -5505 |
| Mapk8 | -6995 | -4957 |
| Atf2 | -5851 | -4104 |
| Mapk9 | -5419 | -3632 |
| Mapk1 | -2283 | -4082 |
| Mapk10 | -5815 | -566 |
| Mapk11 | -4484 | -636 |
| Jun | -7114 | -136 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Atf2 | -5851 | 1618 | -5007 | 8379 | -4104 |
| Fos | -7377 | -4896 | -4344 | -5893 | -5505 |
| Jun | -7114 | -4864 | 3196 | -502 | -136 |
| Mapk1 | -2283 | 2892 | -1870 | 7598 | -4082 |
| Mapk10 | -5815 | -4650 | 667 | -881 | -566 |
| Mapk11 | -4484 | -7856 | 4615 | -5476 | -636 |
| Mapk14 | -1531 | -3847 | 7115 | 1815 | 4054 |
| Mapk3 | 3963 | 1325 | -786 | 4859 | -1528 |
| Mapk8 | -6995 | -5159 | -5271 | 5643 | -4957 |
| Mapk9 | -5419 | 4955 | -2853 | 6354 | -3632 |
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX
| metric | value |
|---|---|
| setSize | 13 |
| pMANOVA | 0.0108 |
| p.adjustMANOVA | 0.0333 |
| s.dist | 0.707 |
| s.hyp | 0.477 |
| s.amy | 0.423 |
| s.hip | -0.3 |
| s.pag | -0.00582 |
| s.ni | 0.0574 |
| p.hyp | 0.00292 |
| p.amy | 0.00826 |
| p.hip | 0.0614 |
| p.pag | 0.971 |
| p.ni | 0.72 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | hyp | amy |
|---|---|---|
| Ptgds | 7543 | 7676 |
| Ptgis | 7917 | 5824 |
| Ptges3 | 6899 | 5576 |
| Hpgd | 7485 | 4698 |
| Prxl2b | 7402 | 4090 |
| Ptgr2 | 1977 | 6244 |
| Ptges | 2268 | 4500 |
| Hpgds | 1936 | 4566 |
| Ptges2 | 6630 | 1199 |
| Tbxas1 | 7842 | 509 |
| Ptgs1 | 144 | 5142 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Cbr1 | -35 | -3929 | 818 | 791 | 2409 |
| Hpgd | 7485 | 4698 | -2015 | 1515 | -6146 |
| Hpgds | 1936 | 4566 | -1531 | 5122 | -576 |
| Prxl2b | 7402 | 4090 | -3338 | -3314 | 424 |
| Ptgds | 7543 | 7676 | 1087 | 8390 | 1533 |
| Ptges | 2268 | 4500 | -2029 | -5864 | 6263 |
| Ptges2 | 6630 | 1199 | -2188 | 1824 | 4480 |
| Ptges3 | 6899 | 5576 | -7452 | -4574 | -4753 |
| Ptgis | 7917 | 5824 | 2069 | 5673 | 6564 |
| Ptgr2 | 1977 | 6244 | -6385 | 646 | 2041 |
| Ptgs1 | 144 | 5142 | -4253 | 5979 | 4087 |
| Ptgs2 | -7660 | -3767 | -2730 | -4284 | -595 |
| Tbxas1 | 7842 | 509 | -1640 | -36 | -3596 |
GLYCOGEN SYNTHESIS
| metric | value |
|---|---|
| setSize | 14 |
| pMANOVA | 0.0176 |
| p.adjustMANOVA | 0.0496 |
| s.dist | 0.706 |
| s.hyp | 0.198 |
| s.amy | 0.462 |
| s.hip | -0.422 |
| s.pag | 0.234 |
| s.ni | -0.116 |
| p.hyp | 0.199 |
| p.amy | 0.00278 |
| p.hip | 0.00623 |
| p.pag | 0.13 |
| p.ni | 0.451 |
Warning in xtfrm.data.frame(x): cannot xtfrm data frames
| Gene | amy | hip |
|---|---|---|
| Ugp2 | 7315 | -7791 |
| Gyg | 6998 | -6331 |
| Ppp1r3c | 4765 | -7788 |
| Rps27a | 6029 | -6007 |
| Gbe1 | 7163 | -3042 |
| Pgm1 | 7832 | -2382 |
| Uba52 | 4466 | -3631 |
| Ubb | 4257 | -1569 |
| Pgm2 | 685 | -5184 |
Click HERE to show all gene set members
| hyp | amy | hip | pag | ni | |
|---|---|---|---|---|---|
| Epm2a | -4826 | -6238 | -3200 | 6462 | 5643 |
| Gbe1 | 2119 | 7163 | -3042 | 8307 | -4172 |
| Gyg | 1849 | 6998 | -6331 | 2210 | -5267 |
| Gys1 | 2516 | 2948 | 6796 | 7471 | 2893 |
| Nhlrc1 | -2216 | 4802 | 134 | 115 | 6414 |
| Pgm1 | 7861 | 7832 | -2382 | 8616 | 7190 |
| Pgm2 | 276 | 685 | -5184 | 1099 | -5272 |
| Pgm2l1 | -1862 | -522 | -5629 | -1591 | -3163 |
| Ppp1r3c | 5103 | 4765 | -7788 | 3042 | -5379 |
| Rps27a | 7081 | 6029 | -6007 | -1859 | -1557 |
| Uba52 | 6847 | 4466 | -3631 | -6715 | 4904 |
| Ubb | 78 | 4257 | -1569 | -1899 | -1838 |
| Ubc | -6658 | -637 | 164 | 5562 | 728 |
| Ugp2 | 5164 | 7315 | -7791 | 8533 | -7310 |
Here is the session info with all the versions of packages used.
sessionInfo()## R version 4.1.3 (2022-03-10)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 20.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/blas/libblas.so.3.9.0
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.9.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
## [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
## [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
## [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## attached base packages:
## [1] parallel stats4 stats graphics grDevices utils datasets
## [8] methods base
##
## other attached packages:
## [1] pkgload_1.2.4 GGally_2.1.2
## [3] gtools_3.9.2 echarts4r_0.4.3
## [5] beeswarm_0.4.0 vioplot_0.3.7
## [7] sm_2.2-5.7 kableExtra_1.3.4
## [9] topconfects_1.8.0 limma_3.48.3
## [11] eulerr_6.1.1 mitch_1.4.1
## [13] MASS_7.3-55 fgsea_1.18.0
## [15] gplots_3.1.1 DESeq2_1.32.0
## [17] SummarizedExperiment_1.22.0 Biobase_2.52.0
## [19] MatrixGenerics_1.4.3 matrixStats_0.61.0
## [21] GenomicRanges_1.44.0 GenomeInfoDb_1.28.4
## [23] IRanges_2.26.0 S4Vectors_0.30.2
## [25] BiocGenerics_0.38.0 reshape2_1.4.4
## [27] forcats_0.5.1 stringr_1.4.0
## [29] dplyr_1.0.8 purrr_0.3.4
## [31] readr_2.1.2 tidyr_1.2.0
## [33] tibble_3.1.6 ggplot2_3.3.5
## [35] tidyverse_1.3.1 zoo_1.8-9
##
## loaded via a namespace (and not attached):
## [1] readxl_1.3.1 backports_1.4.1 fastmatch_1.1-3
## [4] systemfonts_1.0.3 plyr_1.8.6 polylabelr_0.2.0
## [7] splines_4.1.3 BiocParallel_1.26.2 digest_0.6.29
## [10] htmltools_0.5.2 fansi_1.0.2 magrittr_2.0.2
## [13] memoise_2.0.1 tzdb_0.2.0 Biostrings_2.60.2
## [16] annotate_1.70.0 modelr_0.1.8 svglite_2.1.0
## [19] prettyunits_1.1.1 colorspace_2.0-2 blob_1.2.2
## [22] rvest_1.0.2 haven_2.4.3 xfun_0.29
## [25] crayon_1.4.2 RCurl_1.98-1.6 jsonlite_1.7.3
## [28] genefilter_1.74.1 survival_3.2-13 glue_1.6.1
## [31] polyclip_1.10-0 gtable_0.3.0 zlibbioc_1.38.0
## [34] XVector_0.32.0 webshot_0.5.2 DelayedArray_0.18.0
## [37] scales_1.1.1 DBI_1.1.2 Rcpp_1.0.8
## [40] progress_1.2.2 viridisLite_0.4.0 xtable_1.8-4
## [43] bit_4.0.4 htmlwidgets_1.5.4 httr_1.4.2
## [46] RColorBrewer_1.1-2 ellipsis_0.3.2 farver_2.1.0
## [49] pkgconfig_2.0.3 reshape_0.8.8 XML_3.99-0.8
## [52] sass_0.4.0 dbplyr_2.1.1 locfit_1.5-9.4
## [55] utf8_1.2.2 labeling_0.4.2 tidyselect_1.1.1
## [58] rlang_1.0.1 later_1.3.0 AnnotationDbi_1.54.1
## [61] munsell_0.5.0 cellranger_1.1.0 tools_4.1.3
## [64] cachem_1.0.6 cli_3.1.1 generics_0.1.2
## [67] RSQLite_2.2.9 broom_0.7.12 evaluate_0.14
## [70] fastmap_1.1.0 yaml_2.2.2 knitr_1.37
## [73] bit64_4.0.5 fs_1.5.2 caTools_1.18.2
## [76] KEGGREST_1.32.0 mime_0.12 xml2_1.3.3
## [79] compiler_4.1.3 rstudioapi_0.13 png_0.1-7
## [82] reprex_2.0.1 geneplotter_1.70.0 bslib_0.3.1
## [85] stringi_1.7.6 highr_0.9 desc_1.4.0
## [88] lattice_0.20-45 Matrix_1.4-0 vctrs_0.3.8
## [91] pillar_1.7.0 lifecycle_1.0.1 jquerylib_0.1.4
## [94] data.table_1.14.2 bitops_1.0-7 httpuv_1.6.5
## [97] R6_2.5.1 promises_1.2.0.1 KernSmooth_2.23-20
## [100] gridExtra_2.3 assertthat_0.2.1 rprojroot_2.0.2
## [103] withr_2.4.3 GenomeInfoDbData_1.2.6 hms_1.1.1
## [106] grid_4.1.3 rmarkdown_2.11 shiny_1.7.1
## [109] lubridate_1.8.0END of report