date generated: 2022-10-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                        x
## 0610009B22Rik -1.1049767
## 0610009E02Rik  0.6328195
## 0610009L18Rik -1.8903112
## 0610010K14Rik  0.5240337
## 0610012G03Rik -0.2555955
## 0610030E20Rik  0.7313254
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 17516
duplicated_genes_present 0
num_profile_genes_in_sets 8436
num_profile_genes_not_in_sets 9080

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene sets metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 423
num_genesets_included 1181

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 2.96e-04 -0.580 3.39e-03
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 8.60e-04 -0.556 8.54e-03
HSF1 ACTIVATION 27 8.90e-07 -0.546 3.09e-05
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 4.78e-03 -0.515 3.25e-02
ATTENUATION PHASE 25 8.44e-06 -0.515 1.89e-04
EUKARYOTIC TRANSLATION ELONGATION 87 2.50e-16 -0.508 5.91e-14
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 5.76e-03 0.504 3.72e-02
COMPLEX I BIOGENESIS 56 8.77e-11 -0.501 5.76e-09
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 21 9.99e-05 0.490 1.39e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.81e-05 -0.486 3.50e-04
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 5.28e-04 0.486 5.64e-03
CHOLESTEROL BIOSYNTHESIS 24 3.84e-05 -0.485 6.30e-04
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 4.52e-16 -0.482 8.91e-14
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.90e-17 -0.478 7.48e-15
CGMP EFFECTS 15 1.77e-03 0.466 1.53e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 7.40e-04 -0.447 7.47e-03
REDUCTION OF CYTOSOLIC CA LEVELS 11 1.04e-02 0.446 6.23e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.28e-09 -0.445 1.80e-07
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 1.48e-02 0.445 8.09e-02
LONG TERM POTENTIATION 23 2.45e-04 0.442 2.89e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 1.66e-03 0.440 1.48e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 1.17e-02 -0.439 6.69e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 5.24e-04 0.437 5.64e-03
RESPIRATORY ELECTRON TRANSPORT 102 2.50e-14 -0.437 3.28e-12
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 8.65e-06 -0.434 1.89e-04
VOLTAGE GATED POTASSIUM CHANNELS 39 4.31e-06 0.425 1.21e-04
GLYCOGEN STORAGE DISEASES 12 1.08e-02 -0.425 6.35e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 7.53e-05 -0.425 1.11e-03
EUKARYOTIC TRANSLATION INITIATION 114 6.04e-15 -0.423 8.91e-13
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.10e-07 -0.422 4.80e-06
RHOBTB2 GTPASE CYCLE 23 4.91e-04 -0.420 5.37e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.23e-02 -0.417 1.10e-01
EFFECTS OF PIP2 HYDROLYSIS 27 1.77e-04 0.417 2.20e-03
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 1.06e-19 -0.415 6.27e-17
TRAFFICKING OF AMPA RECEPTORS 31 7.78e-05 0.410 1.13e-03
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 60 5.02e-08 -0.407 2.47e-06
SELENOAMINO ACID METABOLISM 110 3.40e-13 -0.402 3.34e-11
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 2.80e-02 0.401 1.32e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 2.48e-03 -0.401 1.96e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.49e-03 0.401 1.96e-02
SIGNALING BY HIPPO 20 2.00e-03 -0.399 1.66e-02
G PROTEIN ACTIVATION 22 1.25e-03 -0.397 1.18e-02
HEDGEHOG LIGAND BIOGENESIS 61 7.95e-08 -0.397 3.76e-06
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.33e-02 -0.397 7.45e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 2.33e-02 0.395 1.14e-01
PD 1 SIGNALING 10 3.16e-02 0.393 1.45e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 9.22e-07 -0.390 3.11e-05
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 8.49e-14 -0.386 1.00e-11
DEGRADATION OF DVL 55 8.10e-07 -0.385 2.97e-05
NONSENSE MEDIATED DECAY NMD 109 5.77e-12 -0.382 4.26e-10


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 13 2.96e-04 -0.580000 3.39e-03
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 8.60e-04 -0.556000 8.54e-03
HSF1 ACTIVATION 27 8.90e-07 -0.546000 3.09e-05
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 4.78e-03 -0.515000 3.25e-02
ATTENUATION PHASE 25 8.44e-06 -0.515000 1.89e-04
EUKARYOTIC TRANSLATION ELONGATION 87 2.50e-16 -0.508000 5.91e-14
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 5.76e-03 0.504000 3.72e-02
COMPLEX I BIOGENESIS 56 8.77e-11 -0.501000 5.76e-09
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 21 9.99e-05 0.490000 1.39e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 1.81e-05 -0.486000 3.50e-04
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 5.28e-04 0.486000 5.64e-03
CHOLESTEROL BIOSYNTHESIS 24 3.84e-05 -0.485000 6.30e-04
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 4.52e-16 -0.482000 8.91e-14
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 1.90e-17 -0.478000 7.48e-15
CGMP EFFECTS 15 1.77e-03 0.466000 1.53e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 7.40e-04 -0.447000 7.47e-03
REDUCTION OF CYTOSOLIC CA LEVELS 11 1.04e-02 0.446000 6.23e-02
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 3.28e-09 -0.445000 1.80e-07
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 1.48e-02 0.445000 8.09e-02
LONG TERM POTENTIATION 23 2.45e-04 0.442000 2.89e-03
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 1.66e-03 0.440000 1.48e-02
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 1.17e-02 -0.439000 6.69e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 5.24e-04 0.437000 5.64e-03
RESPIRATORY ELECTRON TRANSPORT 102 2.50e-14 -0.437000 3.28e-12
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 8.65e-06 -0.434000 1.89e-04
VOLTAGE GATED POTASSIUM CHANNELS 39 4.31e-06 0.425000 1.21e-04
GLYCOGEN STORAGE DISEASES 12 1.08e-02 -0.425000 6.35e-02
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 29 7.53e-05 -0.425000 1.11e-03
EUKARYOTIC TRANSLATION INITIATION 114 6.04e-15 -0.423000 8.91e-13
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 1.10e-07 -0.422000 4.80e-06
RHOBTB2 GTPASE CYCLE 23 4.91e-04 -0.420000 5.37e-03
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 2.23e-02 -0.417000 1.10e-01
EFFECTS OF PIP2 HYDROLYSIS 27 1.77e-04 0.417000 2.20e-03
REGULATION OF EXPRESSION OF SLITS AND ROBOS 161 1.06e-19 -0.415000 6.27e-17
TRAFFICKING OF AMPA RECEPTORS 31 7.78e-05 0.410000 1.13e-03
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 60 5.02e-08 -0.407000 2.47e-06
SELENOAMINO ACID METABOLISM 110 3.40e-13 -0.402000 3.34e-11
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS 10 2.80e-02 0.401000 1.32e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 2.48e-03 -0.401000 1.96e-02
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 2.49e-03 0.401000 1.96e-02
SIGNALING BY HIPPO 20 2.00e-03 -0.399000 1.66e-02
G PROTEIN ACTIVATION 22 1.25e-03 -0.397000 1.18e-02
HEDGEHOG LIGAND BIOGENESIS 61 7.95e-08 -0.397000 3.76e-06
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.33e-02 -0.397000 7.45e-02
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 2.33e-02 0.395000 1.14e-01
PD 1 SIGNALING 10 3.16e-02 0.393000 1.45e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 9.22e-07 -0.390000 3.11e-05
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 8.49e-14 -0.386000 1.00e-11
DEGRADATION OF DVL 55 8.10e-07 -0.385000 2.97e-05
NONSENSE MEDIATED DECAY NMD 109 5.77e-12 -0.382000 4.26e-10
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.72e-02 -0.382000 8.90e-02
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 1.38e-06 -0.380000 4.53e-05
DEGRADATION OF AXIN 53 1.82e-06 -0.379000 5.80e-05
INTERLEUKIN 6 FAMILY SIGNALING 19 4.40e-03 0.377000 3.06e-02
HDR THROUGH MMEJ ALT NHEJ 10 4.17e-02 0.372000 1.78e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 1.10e-02 -0.367000 6.44e-02
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 6.36e-04 -0.366000 6.59e-03
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 1.97e-05 -0.364000 3.76e-04
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 8.81e-09 -0.363000 4.52e-07
CALNEXIN CALRETICULIN CYCLE 26 1.36e-03 -0.363000 1.26e-02
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 2.54e-04 -0.363000 2.97e-03
DEGRADATION OF GLI1 BY THE PROTEASOME 57 2.23e-06 -0.362000 6.74e-05
STABILIZATION OF P53 54 5.19e-06 -0.359000 1.30e-04
PLASMA LIPOPROTEIN REMODELING 17 1.07e-02 0.358000 6.33e-02
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 2.04e-06 -0.358000 6.33e-05
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 5.46e-07 -0.357000 2.15e-05
INFLUENZA INFECTION 145 1.43e-13 -0.356000 1.54e-11
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.22e-03 0.352000 3.47e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 3.57e-03 -0.351000 2.53e-02
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 25 2.43e-03 -0.350000 1.95e-02
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 5.58e-02 0.349000 2.28e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 1.06e-02 0.348000 6.31e-02
ELASTIC FIBRE FORMATION 38 2.28e-04 0.346000 2.75e-03
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 5.06e-03 -0.345000 3.37e-02
CD28 DEPENDENT VAV1 PATHWAY 11 4.93e-02 -0.342000 2.07e-01
LGI ADAM INTERACTIONS 14 2.67e-02 0.342000 1.27e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 70 8.31e-07 -0.341000 2.97e-05
ER QUALITY CONTROL COMPARTMENT ERQC 21 7.15e-03 -0.339000 4.49e-02
SIGNAL AMPLIFICATION 30 1.42e-03 -0.337000 1.30e-02
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 5.26e-03 -0.336000 3.47e-02
SIGNALING BY LEPTIN 10 6.57e-02 0.336000 2.51e-01
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 10 6.61e-02 -0.336000 2.52e-01
SIGNALING BY ROBO RECEPTORS 206 1.04e-16 -0.336000 3.06e-14
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 85 1.09e-07 -0.333000 4.80e-06
TRANSLATION 286 4.41e-22 -0.332000 5.21e-19
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 4.64e-02 -0.332000 1.97e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS 10 7.13e-02 0.329000 2.61e-01
SYNAPTIC ADHESION LIKE MOLECULES 21 9.16e-03 0.329000 5.63e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 1.13e-05 -0.322000 2.38e-04
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 58 2.19e-05 -0.322000 3.99e-04
G1 S DNA DAMAGE CHECKPOINTS 65 7.46e-06 -0.321000 1.78e-04
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 32 1.68e-03 -0.321000 1.48e-02
G BETA GAMMA SIGNALLING THROUGH CDC42 18 1.89e-02 -0.320000 9.64e-02
PREGNENOLONE BIOSYNTHESIS 12 5.61e-02 -0.319000 2.28e-01
INTERACTION BETWEEN L1 AND ANKYRINS 28 3.57e-03 0.318000 2.53e-02
NEPHRIN FAMILY INTERACTIONS 22 9.92e-03 0.318000 6.01e-02
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 6.90e-02 -0.317000 2.57e-01
RHOBTB GTPASE CYCLE 35 1.21e-03 -0.316000 1.15e-02
PYROPTOSIS 21 1.23e-02 -0.316000 6.91e-02
MITOCHONDRIAL TRANSLATION 93 1.53e-07 -0.315000 6.45e-06
METABOLISM OF POLYAMINES 57 4.14e-05 -0.314000 6.69e-04
DAP12 INTERACTIONS 31 2.48e-03 -0.314000 1.96e-02
RORA ACTIVATES GENE EXPRESSION 18 2.16e-02 0.313000 1.08e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 32 2.21e-03 0.313000 1.82e-02
RHOBTB3 ATPASE CYCLE 10 8.71e-02 -0.312000 2.87e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 12 6.15e-02 -0.312000 2.38e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 1.90e-04 -0.311000 2.34e-03
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 3.13e-02 -0.311000 1.44e-01
FGFR1 LIGAND BINDING AND ACTIVATION 10 8.90e-02 0.311000 2.91e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 1.47e-03 -0.311000 1.34e-02
REGULATION OF PTEN STABILITY AND ACTIVITY 66 1.30e-05 -0.310000 2.70e-04
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 2.18e-05 -0.309000 3.99e-04
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 2.33e-02 0.309000 1.14e-01
REGULATION OF RAS BY GAPS 66 1.46e-05 -0.309000 2.97e-04
ANTIGEN PROCESSING CROSS PRESENTATION 94 2.48e-07 -0.308000 1.01e-05
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 6.54e-02 -0.307000 2.51e-01
INTERLEUKIN 7 SIGNALING 18 2.46e-02 0.306000 1.19e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 7.90e-02 -0.306000 2.71e-01
DSCAM INTERACTIONS 10 9.52e-02 0.305000 3.03e-01
STIMULI SENSING CHANNELS 79 2.85e-06 0.305000 8.40e-05
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 2.54e-02 -0.304000 1.22e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 3.37e-03 -0.304000 2.44e-02
CELLULAR RESPONSE TO HYPOXIA 72 8.16e-06 -0.304000 1.89e-04
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 23 1.18e-02 -0.303000 6.75e-02
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 9.81e-02 0.302000 3.10e-01
CELLULAR RESPONSE TO STARVATION 146 3.10e-10 -0.302000 1.93e-08
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 22 1.43e-02 -0.302000 7.87e-02
TRP CHANNELS 21 1.69e-02 0.301000 8.81e-02
METABOLISM OF STEROID HORMONES 22 1.49e-02 -0.300000 8.11e-02
NEUREXINS AND NEUROLIGINS 54 1.39e-04 0.300000 1.83e-03
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 1.01e-01 0.299000 3.15e-01
ORC1 REMOVAL FROM CHROMATIN 68 2.05e-05 -0.299000 3.84e-04
CHONDROITIN SULFATE BIOSYNTHESIS 18 2.83e-02 0.299000 1.33e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 7.51e-02 -0.297000 2.65e-01
ZINC TRANSPORTERS 15 4.69e-02 0.296000 1.99e-01
NEUROTRANSMITTER RELEASE CYCLE 49 3.43e-04 0.296000 3.90e-03
REGULATION OF TLR BY ENDOGENOUS LIGAND 10 1.06e-01 -0.296000 3.20e-01
ION HOMEOSTASIS 48 4.05e-04 0.295000 4.52e-03
KERATAN SULFATE DEGRADATION 12 7.72e-02 0.295000 2.68e-01
INTERLEUKIN 6 SIGNALING 10 1.07e-01 0.294000 3.22e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 3.21e-06 -0.294000 9.26e-05
DAG AND IP3 SIGNALING 40 1.35e-03 0.293000 1.26e-02
HEDGEHOG ON STATE 82 5.02e-06 -0.292000 1.30e-04
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 5.06e-06 -0.291000 1.30e-04
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 82 5.14e-06 -0.291000 1.30e-04
INITIAL TRIGGERING OF COMPLEMENT 11 9.46e-02 0.291000 3.03e-01
DAP12 SIGNALING 24 1.37e-02 -0.291000 7.63e-02
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 1.59e-02 0.290000 8.55e-02
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 1.14e-01 0.289000 3.35e-01
RRNA PROCESSING 194 5.36e-12 -0.287000 4.22e-10
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 1.18e-01 0.285000 3.43e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 4.74e-06 -0.284000 1.30e-04
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 2.01e-02 0.280000 1.02e-01
PHASE 0 RAPID DEPOLARISATION 29 9.31e-03 0.279000 5.68e-02
PERK REGULATES GENE EXPRESSION 28 1.07e-02 -0.279000 6.33e-02
PROTEIN UBIQUITINATION 70 5.63e-05 -0.278000 8.86e-04
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 1.28e-01 -0.278000 3.62e-01
HSF1 DEPENDENT TRANSACTIVATION 35 4.45e-03 -0.278000 3.07e-02
MRNA SPLICING MINOR PATHWAY 52 5.30e-04 -0.278000 5.64e-03
TRIGLYCERIDE CATABOLISM 14 7.39e-02 -0.276000 2.65e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 6.44e-02 0.276000 2.48e-01
GP1B IX V ACTIVATION SIGNALLING 10 1.32e-01 0.275000 3.68e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 1.37e-04 -0.274000 1.82e-03
INTERLEUKIN 12 SIGNALING 36 4.52e-03 -0.273000 3.11e-02
MAPK6 MAPK4 SIGNALING 83 1.76e-05 -0.273000 3.47e-04
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 29 1.11e-02 -0.273000 6.44e-02
CRISTAE FORMATION 31 8.66e-03 -0.272000 5.38e-02
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.03e-01 -0.272000 3.17e-01
HEME SIGNALING 44 1.89e-03 0.271000 1.59e-02
IRAK4 DEFICIENCY TLR2 4 11 1.23e-01 -0.268000 3.51e-01
RNA POLYMERASE I PROMOTER ESCAPE 48 1.32e-03 -0.268000 1.23e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 7.48e-02 -0.266000 2.65e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 68 1.56e-04 -0.265000 2.00e-03
SIGNALING BY ERBB2 ECD MUTANTS 16 6.81e-02 -0.263000 2.56e-01
PLATELET CALCIUM HOMEOSTASIS 26 2.04e-02 0.263000 1.03e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 2.80e-09 -0.263000 1.65e-07
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 4.86e-02 -0.261000 2.05e-01
CONDENSATION OF PROPHASE CHROMOSOMES 28 1.69e-02 -0.261000 8.81e-02
ENDOSOMAL VACUOLAR PATHWAY 11 1.37e-01 -0.259000 3.76e-01
CELLULAR HEXOSE TRANSPORT 11 1.38e-01 0.259000 3.76e-01
PURINE SALVAGE 12 1.22e-01 -0.258000 3.48e-01
SODIUM CALCIUM EXCHANGERS 10 1.59e-01 0.257000 4.06e-01
APOPTOTIC FACTOR MEDIATED RESPONSE 18 5.94e-02 -0.257000 2.35e-01
ABC TRANSPORTER DISORDERS 69 2.36e-04 -0.256000 2.81e-03
TNFR2 NON CANONICAL NF KB PATHWAY 82 6.63e-05 -0.255000 1.00e-03
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 3.95e-04 -0.254000 4.45e-03
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 9.04e-02 -0.253000 2.94e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 2.70e-02 0.251000 1.28e-01
GLYCOGEN SYNTHESIS 14 1.05e-01 -0.250000 3.19e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 1.80e-03 0.250000 1.54e-02
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 9.53e-02 0.249000 3.03e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 6.12e-02 0.248000 2.38e-01
MET ACTIVATES RAP1 AND RAC1 10 1.77e-01 -0.247000 4.35e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 51 2.37e-03 -0.246000 1.92e-02
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 7.91e-02 0.246000 2.71e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 1.27e-01 0.244000 3.61e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 21 5.36e-02 0.243000 2.20e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 1.46e-01 0.242000 3.86e-01
RHO GTPASES ACTIVATE NADPH OXIDASES 20 6.16e-02 0.241000 2.38e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 25 3.81e-02 -0.240000 1.66e-01
REGULATED NECROSIS 46 5.05e-03 -0.239000 3.37e-02
SIGNALING BY NOTCH4 83 1.73e-04 -0.239000 2.19e-03
SCAVENGING OF HEME FROM PLASMA 10 1.92e-01 0.238000 4.54e-01
MITOCHONDRIAL PROTEIN IMPORT 63 1.13e-03 -0.237000 1.09e-02
MUCOPOLYSACCHARIDOSES 11 1.74e-01 0.237000 4.31e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 19 7.41e-02 -0.237000 2.65e-01
CA DEPENDENT EVENTS 36 1.41e-02 0.236000 7.83e-02
CLASS B 2 SECRETIN FAMILY RECEPTORS 71 6.09e-04 -0.235000 6.42e-03
AMINE LIGAND BINDING RECEPTORS 31 2.35e-02 0.235000 1.15e-01
INACTIVATION OF CSF3 G CSF SIGNALING 24 4.64e-02 -0.235000 1.97e-01
HEDGEHOG OFF STATE 106 3.09e-05 -0.234000 5.21e-04
PCP CE PATHWAY 89 1.33e-04 -0.234000 1.79e-03
TRANSCRIPTIONAL REGULATION BY MECP2 59 1.89e-03 0.234000 1.59e-02
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 1.45e-01 0.234000 3.86e-01
METALLOPROTEASE DUBS 26 3.93e-02 -0.234000 1.71e-01
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 2.02e-01 0.233000 4.64e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE 36 1.59e-02 -0.232000 8.55e-02
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 21 6.63e-02 -0.231000 2.52e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 1.22e-01 -0.231000 3.48e-01
MEIOTIC RECOMBINATION 40 1.16e-02 -0.231000 6.69e-02
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 79 4.16e-04 -0.230000 4.59e-03
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 1.02e-01 -0.229000 3.16e-01
MATURATION OF NUCLEOPROTEIN 10 2.10e-01 -0.229000 4.75e-01
UCH PROTEINASES 89 1.97e-04 -0.228000 2.39e-03
DNA METHYLATION 21 7.08e-02 -0.228000 2.60e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 2.91e-04 0.227000 3.36e-03
METABOLISM OF AMINO ACIDS AND DERIVATIVES 318 3.85e-12 -0.227000 3.25e-10
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 14 1.43e-01 -0.226000 3.83e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 8.08e-02 0.226000 2.74e-01
RETROGRADE NEUROTROPHIN SIGNALLING 14 1.48e-01 0.223000 3.86e-01
DISEASES OF DNA REPAIR 11 2.00e-01 -0.223000 4.62e-01
CROSSLINKING OF COLLAGEN FIBRILS 17 1.14e-01 0.221000 3.36e-01
PHOSPHORYLATION OF THE APC C 17 1.16e-01 -0.220000 3.37e-01
ERK MAPK TARGETS 22 7.38e-02 0.220000 2.65e-01
HYALURONAN METABOLISM 16 1.27e-01 0.220000 3.61e-01
NRAGE SIGNALS DEATH THROUGH JNK 55 4.84e-03 0.220000 3.27e-02
DNA REPLICATION PRE INITIATION 81 6.36e-04 -0.220000 6.59e-03
SIGNALING BY EGFR IN CANCER 22 7.46e-02 -0.220000 2.65e-01
CYCLIN D ASSOCIATED EVENTS IN G1 46 1.01e-02 -0.219000 6.10e-02
SIGNALING BY HEDGEHOG 141 7.52e-06 -0.219000 1.78e-04
SMOOTH MUSCLE CONTRACTION 32 3.28e-02 0.218000 1.48e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 64 2.59e-03 -0.218000 2.03e-02
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 5.96e-02 -0.218000 2.35e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 178 5.72e-07 -0.217000 2.18e-05
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 1.21e-01 -0.217000 3.48e-01
CONSTITUTIVE SIGNALING BY EGFRVIII 15 1.46e-01 -0.217000 3.86e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 4.00e-02 0.217000 1.73e-01
ION CHANNEL TRANSPORT 144 8.59e-06 0.215000 1.89e-04
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 1.06e-01 -0.214000 3.21e-01
VLDLR INTERNALISATION AND DEGRADATION 12 2.00e-01 0.213000 4.62e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 64 3.16e-03 -0.213000 2.34e-02
METAL ION SLC TRANSPORTERS 24 7.14e-02 0.213000 2.61e-01
RAS PROCESSING 24 7.20e-02 -0.212000 2.62e-01
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 2.46e-01 -0.212000 5.25e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 33 3.54e-02 0.212000 1.57e-01
PINK1 PRKN MEDIATED MITOPHAGY 22 8.61e-02 -0.211000 2.85e-01
TRANSCRIPTIONAL REGULATION BY RUNX2 109 1.43e-04 -0.211000 1.86e-03
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 8.01e-02 -0.211000 2.73e-01
ASSEMBLY OF THE HIV VIRION 16 1.45e-01 -0.210000 3.86e-01
G2 M CHECKPOINTS 134 2.81e-05 -0.210000 4.87e-04
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 5.45e-03 -0.209000 3.56e-02
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.92e-01 -0.209000 4.54e-01
KERATINIZATION 33 3.82e-02 0.209000 1.66e-01
HIV TRANSCRIPTION INITIATION 45 1.56e-02 -0.208000 8.46e-02
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 1.96e-01 0.207000 4.57e-01
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 5.81e-02 0.207000 2.34e-01
RHOBTB1 GTPASE CYCLE 23 8.61e-02 -0.207000 2.85e-01
FGFR2 ALTERNATIVE SPLICING 25 7.48e-02 -0.206000 2.65e-01
DNA REPLICATION 123 8.13e-05 -0.206000 1.17e-03
MISMATCH REPAIR 14 1.83e-01 -0.206000 4.40e-01
SIGNALING BY FGFR4 IN DISEASE 10 2.61e-01 -0.205000 5.45e-01
JOSEPHIN DOMAIN DUBS 11 2.39e-01 -0.205000 5.16e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 9.10e-02 -0.204000 2.94e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 1.88e-01 0.203000 4.48e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 2.06e-01 -0.203000 4.69e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 87 1.13e-03 0.202000 1.09e-02
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 14 1.93e-01 0.201000 4.55e-01
PROTEIN FOLDING 89 1.09e-03 -0.200000 1.06e-02
S PHASE 156 1.64e-05 -0.200000 3.29e-04
NICOTINAMIDE SALVAGING 16 1.69e-01 -0.199000 4.25e-01
INTERLEUKIN 20 FAMILY SIGNALING 13 2.18e-01 0.197000 4.89e-01
CELLULAR RESPONSE TO CHEMICAL STRESS 151 2.95e-05 -0.197000 5.06e-04
RHOU GTPASE CYCLE 33 5.15e-02 0.196000 2.14e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 3.01e-02 -0.196000 1.40e-01
PI 3K CASCADE FGFR1 16 1.76e-01 0.196000 4.34e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A 25 9.06e-02 -0.196000 2.94e-01
SUMOYLATION OF TRANSCRIPTION FACTORS 17 1.63e-01 -0.195000 4.15e-01
HYALURONAN UPTAKE AND DEGRADATION 12 2.43e-01 0.195000 5.21e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 2.24e-01 0.195000 4.97e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 1.93e-01 0.194000 4.55e-01
HOST INTERACTIONS OF HIV FACTORS 126 1.74e-04 -0.194000 2.19e-03
SURFACTANT METABOLISM 16 1.81e-01 -0.193000 4.39e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 8.94e-02 -0.192000 2.92e-01
FORMATION OF THE CORNIFIED ENVELOPE 32 5.97e-02 0.192000 2.35e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 28 7.87e-02 0.192000 2.71e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 2.71e-01 0.192000 5.54e-01
HS GAG DEGRADATION 21 1.29e-01 0.192000 3.62e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 23 1.12e-01 0.191000 3.34e-01
MRNA SPLICING 188 6.37e-06 -0.191000 1.57e-04
AMYLOID FIBER FORMATION 58 1.20e-02 -0.191000 6.78e-02
INTERLEUKIN 12 FAMILY SIGNALING 42 3.25e-02 -0.191000 1.48e-01
VXPX CARGO TARGETING TO CILIUM 20 1.41e-01 0.190000 3.81e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 21 1.32e-01 0.190000 3.67e-01
SIGNALING BY CSF3 G CSF 29 7.65e-02 -0.190000 2.67e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 2.55e-01 -0.190000 5.37e-01
PI METABOLISM 80 3.41e-03 0.189000 2.45e-02
HDMS DEMETHYLATE HISTONES 28 8.40e-02 0.189000 2.83e-01
METABOLISM OF NUCLEOTIDES 93 1.77e-03 -0.188000 1.53e-02
MRNA CAPPING 29 8.09e-02 -0.187000 2.74e-01
MITOTIC G1 PHASE AND G1 S TRANSITION 144 1.07e-04 -0.187000 1.45e-03
FCERI MEDIATED NF KB ACTIVATION 77 4.55e-03 -0.187000 3.11e-02
ANTIMICROBIAL PEPTIDES 17 1.82e-01 0.187000 4.40e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 1.00e-01 0.186000 3.13e-01
SEPARATION OF SISTER CHROMATIDS 168 3.28e-05 -0.186000 5.46e-04
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 7.83e-02 0.186000 2.70e-01
INWARDLY RECTIFYING K CHANNELS 31 7.45e-02 -0.185000 2.65e-01
METABOLISM OF RNA 645 1.61e-15 -0.184000 2.71e-13
PRC2 METHYLATES HISTONES AND DNA 30 8.07e-02 -0.184000 2.74e-01
DISEASES OF MITOTIC CELL CYCLE 37 5.26e-02 -0.184000 2.18e-01
DCC MEDIATED ATTRACTIVE SIGNALING 14 2.33e-01 -0.184000 5.10e-01
SHC1 EVENTS IN EGFR SIGNALING 11 2.90e-01 -0.184000 5.72e-01
GLYCOGEN METABOLISM 25 1.11e-01 -0.184000 3.33e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 45 3.28e-02 -0.184000 1.48e-01
EXTRA NUCLEAR ESTROGEN SIGNALING 67 9.33e-03 -0.184000 5.68e-02
ADHERENS JUNCTIONS INTERACTIONS 31 7.69e-02 -0.184000 2.68e-01
ECM PROTEOGLYCANS 68 9.01e-03 0.183000 5.57e-02
TRANSCRIPTIONAL REGULATION BY RUNX3 93 2.33e-03 -0.183000 1.91e-02
RETINOID CYCLE DISEASE EVENTS 11 2.95e-01 0.183000 5.74e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 77 5.67e-03 -0.182000 3.68e-02
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 7.49e-02 0.182000 2.65e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING 27 1.02e-01 0.182000 3.16e-01
MUSCLE CONTRACTION 157 9.64e-05 0.180000 1.36e-03
FANCONI ANEMIA PATHWAY 36 6.10e-02 0.180000 2.38e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 3.24e-01 -0.180000 5.98e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 2.13e-01 0.180000 4.79e-01
NEURONAL SYSTEM 369 3.36e-09 0.180000 1.80e-07
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 91 3.18e-03 0.179000 2.34e-02
ENOS ACTIVATION 11 3.04e-01 -0.179000 5.85e-01
SIGNALING BY THE B CELL RECEPTOR BCR 104 1.63e-03 -0.179000 1.46e-02
GLUCAGON TYPE LIGAND RECEPTORS 26 1.15e-01 -0.178000 3.37e-01
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 3.30e-01 0.178000 6.00e-01
BUDDING AND MATURATION OF HIV VIRION 27 1.10e-01 -0.178000 3.29e-01
SIGNALING BY NODAL 16 2.20e-01 0.177000 4.92e-01
NETRIN 1 SIGNALING 49 3.22e-02 0.177000 1.47e-01
CLEC7A DECTIN 1 SIGNALING 94 3.07e-03 -0.177000 2.31e-02
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 3.27e-03 -0.177000 2.38e-02
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 3.13e-01 0.176000 5.93e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 6.15e-02 0.175000 2.38e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 8.62e-02 -0.175000 2.85e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 2.59e-02 0.175000 1.24e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 32 8.65e-02 0.175000 2.85e-01
TRAF6 MEDIATED IRF7 ACTIVATION 15 2.42e-01 -0.175000 5.21e-01
RIPK1 MEDIATED REGULATED NECROSIS 25 1.32e-01 -0.174000 3.68e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 14 2.62e-01 0.173000 5.45e-01
NUCLEOBASE BIOSYNTHESIS 15 2.46e-01 -0.173000 5.24e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 2.81e-01 -0.173000 5.65e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 3.22e-01 0.173000 5.97e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 2.48e-01 -0.172000 5.26e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 68 1.43e-02 0.172000 7.87e-02
NUCLEOTIDE SALVAGE 21 1.74e-01 -0.172000 4.31e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI 604 7.66e-13 -0.171000 6.96e-11
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 48 4.08e-02 -0.171000 1.76e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT 193 4.48e-05 0.171000 7.15e-04
ESTROGEN DEPENDENT GENE EXPRESSION 105 2.62e-03 -0.170000 2.04e-02
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 66 1.73e-02 -0.170000 8.90e-02
TP53 REGULATES METABOLIC GENES 85 7.11e-03 -0.169000 4.49e-02
FERTILIZATION 12 3.12e-01 -0.168000 5.93e-01
BASE EXCISION REPAIR AP SITE FORMATION 30 1.11e-01 -0.168000 3.32e-01
INTERLEUKIN 17 SIGNALING 66 1.83e-02 0.168000 9.33e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 2.94e-01 -0.168000 5.74e-01
ACTIVATION OF RAC1 13 2.95e-01 -0.168000 5.74e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 9.12e-06 -0.168000 1.96e-04
RESOLUTION OF D LOOP STRUCTURES 30 1.13e-01 0.167000 3.34e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 2.97e-01 0.167000 5.74e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 1.42e-01 -0.167000 3.82e-01
CYTOPROTECTION BY HMOX1 120 1.64e-03 -0.167000 1.46e-02
SULFUR AMINO ACID METABOLISM 24 1.58e-01 -0.166000 4.05e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 1.21e-01 -0.166000 3.48e-01
CARDIAC CONDUCTION 107 2.95e-03 0.166000 2.24e-02
CS DS DEGRADATION 14 2.83e-01 0.166000 5.66e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 71 1.61e-02 -0.165000 8.61e-02
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 1.06e-01 -0.165000 3.20e-01
SIGNALING BY NOTCH 189 9.39e-05 -0.165000 1.34e-03
GABA B RECEPTOR ACTIVATION 39 7.83e-02 -0.163000 2.70e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 3.29e-01 0.163000 5.99e-01
MITOTIC METAPHASE AND ANAPHASE 209 5.73e-05 -0.162000 8.90e-04
NUCLEAR ENVELOPE BREAKDOWN 49 5.05e-02 0.162000 2.11e-01
ION TRANSPORT BY P TYPE ATPASES 48 5.32e-02 0.161000 2.20e-01
SUPPRESSION OF PHAGOSOMAL MATURATION 13 3.14e-01 -0.161000 5.94e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 3.81e-01 0.160000 6.60e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 2.85e-01 -0.160000 5.68e-01
SHC MEDIATED CASCADE FGFR4 13 3.19e-01 -0.160000 5.96e-01
TRIGLYCERIDE METABOLISM 24 1.78e-01 -0.159000 4.35e-01
SYNTHESIS OF PC 26 1.61e-01 0.159000 4.10e-01
SLC TRANSPORTER DISORDERS 77 1.64e-02 0.158000 8.66e-02
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 6.97e-02 -0.158000 2.58e-01
RHO GTPASES ACTIVATE PKNS 48 5.96e-02 -0.157000 2.35e-01
MITOPHAGY 29 1.44e-01 -0.157000 3.84e-01
METABOLISM OF COFACTORS 19 2.36e-01 -0.157000 5.14e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 1.94e-01 -0.156000 4.56e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 15 2.95e-01 0.156000 5.74e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 2.27e-01 0.156000 5.03e-01
CELL CYCLE CHECKPOINTS 245 2.70e-05 -0.156000 4.77e-04
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 1.40e-01 -0.156000 3.81e-01
REPRESSION OF WNT TARGET GENES 14 3.13e-01 -0.156000 5.93e-01
HIV INFECTION 222 6.48e-05 -0.156000 9.94e-04
G2 M DNA DAMAGE CHECKPOINT 66 2.88e-02 -0.156000 1.35e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 33 1.22e-01 -0.156000 3.48e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES 13 3.33e-01 -0.155000 6.03e-01
SCAVENGING BY CLASS A RECEPTORS 14 3.16e-01 0.155000 5.94e-01
SENSORY PROCESSING OF SOUND 62 3.51e-02 0.155000 1.56e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 1.72e-01 0.155000 4.31e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 2.57e-01 -0.154000 5.41e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 1.58e-01 -0.154000 4.05e-01
BETA CATENIN INDEPENDENT WNT SIGNALING 137 1.90e-03 -0.154000 1.59e-02
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 11 3.77e-01 -0.154000 6.56e-01
SIGNALING BY ERBB2 IN CANCER 25 1.84e-01 -0.154000 4.40e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 3.21e-01 -0.153000 5.96e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 1.76e-01 0.153000 4.35e-01
CD28 DEPENDENT PI3K AKT SIGNALING 21 2.24e-01 0.153000 4.97e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 2.05e-01 -0.153000 4.69e-01
FORMATION OF THE EARLY ELONGATION COMPLEX 33 1.29e-01 -0.153000 3.64e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 3.83e-01 0.152000 6.60e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 2.93e-01 -0.152000 5.74e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 2.65e-01 -0.152000 5.46e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 3.64e-01 0.151000 6.40e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 11 3.85e-01 0.151000 6.60e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 3.86e-01 0.151000 6.60e-01
ESR MEDIATED SIGNALING 168 7.49e-04 -0.151000 7.50e-03
SIGNALING BY WNT 268 2.40e-05 -0.150000 4.29e-04
RAP1 SIGNALLING 15 3.17e-01 0.149000 5.94e-01
G0 AND EARLY G1 25 1.97e-01 -0.149000 4.57e-01
NOTCH HLH TRANSCRIPTION PATHWAY 28 1.73e-01 0.149000 4.31e-01
PHASE 2 PLATEAU PHASE 11 3.94e-01 0.148000 6.60e-01
C TYPE LECTIN RECEPTORS CLRS 113 6.55e-03 -0.148000 4.20e-02
TRANSCRIPTION OF THE HIV GENOME 67 3.70e-02 -0.147000 1.63e-01
INFECTIOUS DISEASE 738 1.23e-11 -0.147000 8.56e-10
PIWI INTERACTING RNA PIRNA BIOGENESIS 21 2.46e-01 -0.146000 5.24e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 2.96e-01 -0.146000 5.74e-01
SEROTONIN RECEPTORS 10 4.24e-01 0.146000 6.79e-01
RNA POLYMERASE I TRANSCRIPTION 68 3.80e-02 -0.146000 1.66e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES 241 1.01e-04 0.146000 1.39e-03
FCERI MEDIATED MAPK ACTIVATION 28 1.84e-01 -0.145000 4.40e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 3.39e-02 -0.145000 1.52e-01
GENERATION OF SECOND MESSENGER MOLECULES 20 2.64e-01 0.144000 5.46e-01
INTERFERON ALPHA BETA SIGNALING 58 5.89e-02 -0.143000 2.35e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 4.11e-01 -0.143000 6.75e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 3.23e-01 0.143000 5.97e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 2.36e-01 -0.143000 5.14e-01
CELLULAR RESPONSE TO HEAT STRESS 96 1.62e-02 -0.142000 8.62e-02
TRANSCRIPTIONAL REGULATION BY RUNX1 179 1.08e-03 -0.142000 1.06e-02
PI3K AKT SIGNALING IN CANCER 89 2.09e-02 0.142000 1.05e-01
GABA RECEPTOR ACTIVATION 53 7.43e-02 -0.142000 2.65e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 35 1.47e-01 0.142000 3.86e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 1.73e-01 0.141000 4.31e-01
SIGNALING BY TGFB FAMILY MEMBERS 97 1.63e-02 -0.141000 8.62e-02
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 47 9.44e-02 -0.141000 3.03e-01
CARNITINE METABOLISM 14 3.62e-01 0.141000 6.39e-01
PLATELET SENSITIZATION BY LDL 15 3.45e-01 -0.141000 6.17e-01
ASPARTATE AND ASPARAGINE METABOLISM 11 4.21e-01 0.140000 6.78e-01
COMPLEMENT CASCADE 27 2.07e-01 0.140000 4.70e-01
CDC42 GTPASE CYCLE 154 2.69e-03 0.140000 2.08e-02
PROTEIN LOCALIZATION 158 2.37e-03 -0.140000 1.92e-02
CTLA4 INHIBITORY SIGNALING 20 2.78e-01 -0.140000 5.62e-01
SIGNALING BY ERBB4 57 6.75e-02 -0.140000 2.55e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 19 2.91e-01 -0.140000 5.72e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 1.78e-01 -0.140000 4.35e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 36 1.46e-01 0.140000 3.86e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 4.22e-01 0.140000 6.78e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 21 2.67e-01 -0.140000 5.50e-01
E2F MEDIATED REGULATION OF DNA REPLICATION 20 2.79e-01 -0.140000 5.63e-01
POTASSIUM CHANNELS 90 2.21e-02 0.140000 1.09e-01
CYTOSOLIC TRNA AMINOACYLATION 24 2.38e-01 -0.139000 5.15e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 3.85e-01 -0.139000 6.60e-01
FC EPSILON RECEPTOR FCERI SIGNALING 124 7.51e-03 -0.139000 4.69e-02
RHO GTPASES ACTIVATE KTN1 11 4.25e-01 -0.139000 6.80e-01
FRS MEDIATED FGFR1 SIGNALING 18 3.09e-01 0.138000 5.92e-01
TELOMERE C STRAND SYNTHESIS INITIATION 13 3.88e-01 0.138000 6.60e-01
SEMA3A PAK DEPENDENT AXON REPULSION 16 3.40e-01 -0.138000 6.10e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 48 9.85e-02 0.138000 3.10e-01
G PROTEIN MEDIATED EVENTS 52 8.59e-02 0.138000 2.85e-01
P75NTR RECRUITS SIGNALLING COMPLEXES 13 3.91e-01 -0.137000 6.60e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 90 2.50e-02 0.137000 1.21e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 1.17e-01 -0.137000 3.41e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 39 1.41e-01 -0.136000 3.81e-01
DUAL INCISION IN TC NER 65 5.82e-02 -0.136000 2.34e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING 25 2.40e-01 0.136000 5.17e-01
PTEN REGULATION 134 6.75e-03 -0.136000 4.30e-02
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 2.71e-01 0.136000 5.54e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 20 2.95e-01 -0.135000 5.74e-01
BASIGIN INTERACTIONS 22 2.73e-01 -0.135000 5.56e-01
RHOB GTPASE CYCLE 67 5.63e-02 0.135000 2.29e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 22 2.76e-01 -0.134000 5.61e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 3.25e-01 0.134000 5.98e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 36 1.64e-01 -0.134000 4.17e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 3.54e-01 -0.134000 6.27e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 4.64e-01 -0.134000 7.04e-01
CELL CELL JUNCTION ORGANIZATION 50 1.02e-01 -0.134000 3.16e-01
RHO GTPASES ACTIVATE PAKS 21 2.90e-01 0.133000 5.72e-01
EARLY PHASE OF HIV LIFE CYCLE 14 3.88e-01 -0.133000 6.60e-01
PEPTIDE HORMONE METABOLISM 62 7.02e-02 -0.133000 2.59e-01
SYNDECAN INTERACTIONS 27 2.34e-01 0.132000 5.11e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 3.76e-01 -0.132000 6.54e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 58 8.21e-02 0.132000 2.77e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS 13 4.10e-01 -0.132000 6.75e-01
NOD1 2 SIGNALING PATHWAY 34 1.83e-01 0.132000 4.40e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING 21 2.97e-01 -0.132000 5.74e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 40 1.51e-01 0.131000 3.91e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 29 2.23e-01 0.131000 4.97e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 62 7.60e-02 -0.130000 2.67e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 4.54e-01 -0.130000 7.01e-01
OTHER INTERLEUKIN SIGNALING 21 3.02e-01 0.130000 5.82e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 2.02e-01 -0.130000 4.64e-01
NONHOMOLOGOUS END JOINING NHEJ 44 1.37e-01 -0.130000 3.76e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 4.39e-01 -0.129000 6.92e-01
RUNX3 REGULATES NOTCH SIGNALING 13 4.22e-01 0.129000 6.78e-01
G PROTEIN BETA GAMMA SIGNALLING 30 2.23e-01 -0.129000 4.97e-01
MET ACTIVATES PTK2 SIGNALING 29 2.32e-01 0.128000 5.09e-01
INTRAFLAGELLAR TRANSPORT 51 1.13e-01 -0.128000 3.34e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 2.77e-01 -0.128000 5.62e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS 15 3.91e-01 0.128000 6.60e-01
MITOTIC G2 G2 M PHASES 184 2.89e-03 -0.127000 2.21e-02
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 11 4.64e-01 -0.127000 7.04e-01
SIGNALING BY FGFR2 IN DISEASE 37 1.81e-01 -0.127000 4.39e-01
APOPTOSIS 163 5.37e-03 -0.126000 3.53e-02
TRANSCRIPTIONAL REGULATION BY E2F6 34 2.02e-01 -0.126000 4.64e-01
PHOSPHOLIPID METABOLISM 187 2.91e-03 0.126000 2.21e-02
PROGRAMMED CELL DEATH 185 3.14e-03 -0.126000 2.34e-02
FORMATION OF TC NER PRE INCISION COMPLEX 53 1.13e-01 -0.126000 3.34e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 30 2.34e-01 0.126000 5.11e-01
ENDOGENOUS STEROLS 21 3.19e-01 0.126000 5.96e-01
PYRIMIDINE SALVAGE 10 4.92e-01 -0.126000 7.21e-01
INTERLEUKIN 1 SIGNALING 96 3.37e-02 -0.125000 1.52e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 4.55e-01 0.124000 7.01e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 12 4.56e-01 -0.124000 7.01e-01
THE NLRP3 INFLAMMASOME 15 4.05e-01 -0.124000 6.72e-01
OVARIAN TUMOR DOMAIN PROTEASES 36 1.97e-01 -0.124000 4.57e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 5.88e-02 -0.124000 2.35e-01
MITOCHONDRIAL TRNA AMINOACYLATION 21 3.26e-01 -0.124000 5.98e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 28 2.57e-01 -0.124000 5.41e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 20 3.39e-01 -0.124000 6.10e-01
TRNA AMINOACYLATION 42 1.68e-01 -0.123000 4.24e-01
DOWNREGULATION OF ERBB2 SIGNALING 28 2.62e-01 -0.122000 5.45e-01
ANCHORING FIBRIL FORMATION 15 4.12e-01 0.122000 6.75e-01
SIGNALING BY ACTIVIN 12 4.64e-01 0.122000 7.04e-01
FGFR2 LIGAND BINDING AND ACTIVATION 12 4.64e-01 0.122000 7.04e-01
TRANSLESION SYNTHESIS BY POLK 17 3.84e-01 -0.122000 6.60e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 4.30e-01 -0.122000 6.85e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 12 4.66e-01 0.122000 7.05e-01
TCR SIGNALING 102 3.40e-02 -0.122000 1.52e-01
RHO GTPASES ACTIVATE CIT 18 3.73e-01 0.121000 6.52e-01
UB SPECIFIC PROCESSING PROTEASES 168 6.78e-03 -0.121000 4.30e-02
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 3.27e-01 0.121000 5.98e-01
BILE ACID AND BILE SALT METABOLISM 25 2.96e-01 0.121000 5.74e-01
PHASE II CONJUGATION OF COMPOUNDS 62 1.00e-01 -0.121000 3.13e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 4.88e-01 0.121000 7.21e-01
GLYCOSAMINOGLYCAN METABOLISM 117 2.46e-02 0.120000 1.19e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 42 1.78e-01 0.120000 4.35e-01
RUNX2 REGULATES BONE DEVELOPMENT 29 2.63e-01 -0.120000 5.46e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 4.22e-01 0.120000 6.78e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 4.23e-01 -0.120000 6.78e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 3.93e-01 0.120000 6.60e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 3.46e-01 -0.119000 6.17e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 50 1.46e-01 -0.119000 3.86e-01
OLFACTORY SIGNALING PATHWAY 30 2.61e-01 0.119000 5.45e-01
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 4.43e-01 -0.119000 6.96e-01
ACYL CHAIN REMODELLING OF PC 16 4.12e-01 -0.118000 6.75e-01
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.28e-01 -0.118000 5.98e-01
NUCLEAR IMPORT OF REV PROTEIN 32 2.49e-01 0.118000 5.27e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 24 3.21e-01 0.117000 5.96e-01
BETA CATENIN PHOSPHORYLATION CASCADE 16 4.18e-01 -0.117000 6.78e-01
ERYTHROPOIETIN ACTIVATES RAS 13 4.69e-01 -0.116000 7.07e-01
PLATELET HOMEOSTASIS 78 7.64e-02 0.116000 2.67e-01
PI 3K CASCADE FGFR3 14 4.53e-01 0.116000 7.01e-01
STRIATED MUSCLE CONTRACTION 24 3.27e-01 0.116000 5.98e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 61 1.19e-01 0.116000 3.44e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 1.80e-01 -0.115000 4.39e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 5.27e-01 -0.115000 7.38e-01
FORMATION OF APOPTOSOME 10 5.28e-01 -0.115000 7.38e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 3.38e-01 0.115000 6.10e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS 13 4.72e-01 -0.115000 7.10e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 84 6.84e-02 0.115000 2.56e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS 16 4.27e-01 0.115000 6.81e-01
UNWINDING OF DNA 12 4.92e-01 0.115000 7.21e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 3.88e-01 -0.114000 6.60e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 1.58e-01 0.114000 4.05e-01
PROCESSING AND ACTIVATION OF SUMO 10 5.32e-01 -0.114000 7.41e-01
GLUTATHIONE CONJUGATION 29 2.88e-01 -0.114000 5.71e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 12 4.96e-01 0.113000 7.21e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS 12 4.97e-01 -0.113000 7.21e-01
REPRODUCTION 78 8.55e-02 -0.113000 2.85e-01
RHOJ GTPASE CYCLE 54 1.53e-01 0.112000 3.95e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION 21 3.75e-01 0.112000 6.54e-01
BIOTIN TRANSPORT AND METABOLISM 11 5.21e-01 0.112000 7.38e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 4.54e-01 -0.112000 7.01e-01
SIGNALING BY WNT IN CANCER 31 2.82e-01 -0.112000 5.66e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 4.57e-01 -0.111000 7.01e-01
PROLONGED ERK ACTIVATION EVENTS 14 4.72e-01 0.111000 7.10e-01
MYOGENESIS 24 3.47e-01 0.111000 6.18e-01
HEME BIOSYNTHESIS 13 4.90e-01 0.111000 7.21e-01
PECAM1 INTERACTIONS 12 5.09e-01 0.110000 7.29e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 4.20e-01 0.110000 6.78e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 53 1.68e-01 0.110000 4.23e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 3.16e-01 -0.109000 5.94e-01
CELL JUNCTION ORGANIZATION 74 1.04e-01 -0.109000 3.18e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 15 4.63e-01 -0.109000 7.04e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 62 1.37e-01 0.109000 3.76e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 2.16e-01 0.109000 4.85e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 2.94e-01 -0.109000 5.74e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 63 1.35e-01 -0.109000 3.75e-01
RA BIOSYNTHESIS PATHWAY 13 4.99e-01 -0.108000 7.22e-01
METHYLATION 12 5.16e-01 -0.108000 7.35e-01
NICOTINATE METABOLISM 26 3.40e-01 -0.108000 6.10e-01
PROLACTIN RECEPTOR SIGNALING 12 5.17e-01 -0.108000 7.35e-01
SIGNALING BY NOTCH3 48 1.97e-01 -0.108000 4.57e-01
INTERLEUKIN RECEPTOR SHC SIGNALING 20 4.06e-01 -0.107000 6.72e-01
HIV TRANSCRIPTION ELONGATION 42 2.29e-01 -0.107000 5.06e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 5.38e-01 0.107000 7.46e-01
RHO GTPASES ACTIVATE ROCKS 19 4.21e-01 0.107000 6.78e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 14 4.93e-01 -0.106000 7.21e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 5.63e-01 0.106000 7.59e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 5.63e-01 0.106000 7.59e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 5.11e-01 0.105000 7.29e-01
EPHB MEDIATED FORWARD SIGNALING 42 2.38e-01 -0.105000 5.15e-01
RESPONSE OF MTB TO PHAGOCYTOSIS 22 3.94e-01 -0.105000 6.60e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 17 4.54e-01 -0.105000 7.01e-01
INSULIN RECEPTOR SIGNALLING CASCADE 45 2.24e-01 0.105000 4.97e-01
DISEASES OF IMMUNE SYSTEM 22 3.95e-01 -0.105000 6.60e-01
GAP JUNCTION ASSEMBLY 21 4.07e-01 -0.105000 6.72e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 4.98e-01 -0.105000 7.22e-01
MITOTIC SPINDLE CHECKPOINT 99 7.33e-02 -0.104000 2.65e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 4.44e-01 -0.104000 6.96e-01
PENTOSE PHOSPHATE PATHWAY 13 5.17e-01 -0.104000 7.35e-01
APOPTOSIS INDUCED DNA FRAGMENTATION 10 5.72e-01 0.103000 7.66e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 45 2.32e-01 -0.103000 5.09e-01
MAP2K AND MAPK ACTIVATION 36 2.87e-01 -0.103000 5.70e-01
MEIOSIS 66 1.51e-01 -0.102000 3.91e-01
UNFOLDED PROTEIN RESPONSE UPR 86 1.01e-01 -0.102000 3.15e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 12 5.40e-01 0.102000 7.48e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 3.04e-01 0.102000 5.85e-01
METABOLISM OF STEROIDS 116 5.86e-02 -0.102000 2.35e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 4.96e-01 0.102000 7.21e-01
TELOMERE MAINTENANCE 79 1.20e-01 -0.101000 3.47e-01
REGULATION OF IFNG SIGNALING 13 5.28e-01 0.101000 7.38e-01
PLASMA LIPOPROTEIN CLEARANCE 27 3.64e-01 -0.101000 6.40e-01
SIGNALING BY NTRKS 128 4.91e-02 0.101000 2.06e-01
SENSORY PERCEPTION 154 3.12e-02 0.101000 1.44e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 2.53e-01 -0.101000 5.36e-01
RAC1 GTPASE CYCLE 177 2.15e-02 0.100000 1.08e-01
NEUTROPHIL DEGRANULATION 390 7.05e-04 -0.100000 7.24e-03
RAB GERANYLGERANYLATION 58 1.88e-01 -0.100000 4.48e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 46 2.47e-01 0.098800 5.25e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 344 1.69e-03 -0.098700 1.48e-02
O LINKED GLYCOSYLATION 86 1.15e-01 0.098300 3.37e-01
BRANCHED CHAIN AMINO ACID CATABOLISM 21 4.36e-01 -0.098200 6.90e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS 58 1.96e-01 0.098200 4.57e-01
ACYL CHAIN REMODELLING OF PG 10 5.91e-01 -0.098200 7.73e-01
FGFR2 MUTANT RECEPTOR ACTIVATION 27 3.78e-01 -0.098000 6.57e-01
CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX 10 5.92e-01 -0.098000 7.73e-01
SIGNALING BY FGFR2 IIIA TM 19 4.60e-01 -0.098000 7.04e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 95 9.92e-02 0.097900 3.11e-01
TRANS GOLGI NETWORK VESICLE BUDDING 69 1.61e-01 -0.097600 4.10e-01
SIALIC ACID METABOLISM 32 3.40e-01 0.097500 6.10e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 5.43e-01 -0.097500 7.49e-01
SARS COV 2 INFECTION 65 1.74e-01 -0.097500 4.32e-01
P38MAPK EVENTS 12 5.60e-01 -0.097200 7.58e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 4.53e-01 0.096900 7.01e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 79 1.37e-01 -0.096800 3.76e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 5.46e-01 0.096700 7.49e-01
LYSOSOME VESICLE BIOGENESIS 32 3.46e-01 -0.096300 6.17e-01
DISEASES OF GLYCOSYLATION 125 6.35e-02 0.096200 2.45e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 1.40e-01 -0.096100 3.81e-01
TRANSPORT OF SMALL MOLECULES 587 7.47e-05 0.096000 1.11e-03
L1CAM INTERACTIONS 109 8.43e-02 0.095800 2.83e-01
OXIDATIVE STRESS INDUCED SENESCENCE 79 1.42e-01 -0.095600 3.82e-01
RMTS METHYLATE HISTONE ARGININES 44 2.73e-01 -0.095600 5.56e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 4.84e-01 -0.095400 7.18e-01
PHASE 4 RESTING MEMBRANE POTENTIAL 14 5.38e-01 -0.095000 7.46e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION 35 3.32e-01 -0.094800 6.03e-01
SIGNALING BY EGFR 47 2.64e-01 -0.094300 5.46e-01
EXTRACELLULAR MATRIX ORGANIZATION 245 1.15e-02 0.093900 6.65e-02
SIGNALING BY BMP 25 4.17e-01 -0.093900 6.78e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 25 4.17e-01 -0.093800 6.78e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 4.10e-01 -0.093400 6.75e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX 108 9.44e-02 0.093200 3.03e-01
NGF STIMULATED TRANSCRIPTION 36 3.34e-01 0.093000 6.04e-01
M PHASE 343 3.19e-03 -0.092800 2.34e-02
SIGNALING BY NUCLEAR RECEPTORS 225 1.77e-02 -0.091900 9.07e-02
SIGNALING BY ERBB2 49 2.68e-01 -0.091500 5.50e-01
DOWNSTREAM SIGNAL TRANSDUCTION 29 3.95e-01 0.091300 6.60e-01
COPII MEDIATED VESICLE TRANSPORT 65 2.04e-01 0.091200 4.66e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 1.78e-01 0.091100 4.35e-01
BASE EXCISION REPAIR 58 2.31e-01 -0.091000 5.08e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 5.71e-01 -0.090800 7.66e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING 28 4.06e-01 0.090700 6.72e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 3.28e-01 -0.090600 5.98e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 12 5.89e-01 -0.090200 7.73e-01
SARS COV INFECTIONS 140 6.65e-02 -0.089900 2.52e-01
FORMATION OF INCISION COMPLEX IN GG NER 43 3.08e-01 -0.089800 5.91e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 3.20e-01 0.089700 5.96e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 4.13e-01 0.089400 6.75e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 21 4.81e-01 -0.088900 7.16e-01
RHOD GTPASE CYCLE 50 2.82e-01 0.088000 5.66e-01
TELOMERE EXTENSION BY TELOMERASE 22 4.77e-01 -0.087600 7.14e-01
NEGATIVE REGULATION OF FLT3 14 5.72e-01 0.087300 7.66e-01
MYD88 INDEPENDENT TLR4 CASCADE 92 1.48e-01 0.087300 3.86e-01
INTERLEUKIN 37 SIGNALING 18 5.22e-01 0.087100 7.38e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 4.34e-01 -0.086900 6.89e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 5.03e-01 -0.086600 7.25e-01
RECYCLING PATHWAY OF L1 40 3.43e-01 0.086600 6.15e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 13 5.89e-01 0.086500 7.73e-01
SIGNALING BY RETINOIC ACID 33 3.91e-01 0.086300 6.60e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 58 2.58e-01 0.085800 5.42e-01
SIGNALING BY PTK6 52 2.85e-01 -0.085700 5.68e-01
ERBB2 REGULATES CELL MOTILITY 14 5.80e-01 -0.085500 7.69e-01
INTERLEUKIN 1 FAMILY SIGNALING 122 1.03e-01 -0.085400 3.17e-01
EPHA MEDIATED GROWTH CONE COLLAPSE 28 4.34e-01 0.085400 6.89e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 20 5.11e-01 -0.085000 7.29e-01
DNA DOUBLE STRAND BREAK RESPONSE 53 2.85e-01 -0.084900 5.68e-01
INTERFERON GAMMA SIGNALING 80 1.90e-01 -0.084900 4.51e-01
SYNTHESIS OF PE 13 5.96e-01 0.084900 7.76e-01
COLLAGEN FORMATION 79 1.93e-01 -0.084800 4.55e-01
NERVOUS SYSTEM DEVELOPMENT 550 7.20e-04 -0.084600 7.33e-03
CD209 DC SIGN SIGNALING 18 5.35e-01 -0.084400 7.44e-01
REGULATION OF SIGNALING BY CBL 22 4.94e-01 -0.084300 7.21e-01
CLATHRIN MEDIATED ENDOCYTOSIS 134 9.23e-02 0.084300 2.98e-01
AQUAPORIN MEDIATED TRANSPORT 39 3.64e-01 -0.084000 6.40e-01
METABOLISM OF PORPHYRINS 19 5.28e-01 0.083700 7.38e-01
PEROXISOMAL LIPID METABOLISM 26 4.61e-01 0.083600 7.04e-01
PKMTS METHYLATE HISTONE LYSINES 49 3.13e-01 0.083400 5.93e-01
TIGHT JUNCTION INTERACTIONS 17 5.54e-01 -0.082900 7.52e-01
PRE NOTCH PROCESSING IN GOLGI 17 5.54e-01 0.082900 7.52e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 5.93e-01 0.082600 7.74e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 5.68e-01 0.082500 7.64e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 6.21e-01 0.082500 7.97e-01
SPRY REGULATION OF FGF SIGNALING 16 5.68e-01 0.082400 7.64e-01
NUCLEOTIDE EXCISION REPAIR 110 1.37e-01 -0.082100 3.76e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 4.44e-01 0.082100 6.96e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 22 5.05e-01 0.082100 7.27e-01
RHO GTPASES ACTIVATE IQGAPS 24 4.87e-01 -0.082000 7.21e-01
DEUBIQUITINATION 242 2.84e-02 -0.081900 1.33e-01
HDACS DEACETYLATE HISTONES 47 3.33e-01 -0.081600 6.03e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 3.67e-01 -0.081400 6.43e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 6.40e-01 -0.081400 8.09e-01
FORMATION OF RNA POL II ELONGATION COMPLEX 57 2.89e-01 -0.081300 5.71e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 52 3.11e-01 0.081300 5.93e-01
RESOLUTION OF SISTER CHROMATID COHESION 104 1.53e-01 -0.081200 3.95e-01
HIV LIFE CYCLE 143 9.53e-02 -0.080900 3.03e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 5.32e-01 0.080800 7.41e-01
INSULIN PROCESSING 24 4.94e-01 0.080700 7.21e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 91 1.84e-01 0.080700 4.40e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 6.15e-01 -0.080700 7.92e-01
RHOA GTPASE CYCLE 143 9.65e-02 0.080600 3.06e-01
TRANSCRIPTIONAL REGULATION BY VENTX 35 4.12e-01 -0.080200 6.75e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 5.80e-01 -0.079900 7.69e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 4.02e-01 0.079700 6.68e-01
SHC MEDIATED CASCADE FGFR1 16 5.82e-01 0.079500 7.69e-01
KETONE BODY METABOLISM 10 6.64e-01 -0.079300 8.26e-01
DISEASES OF CARBOHYDRATE METABOLISM 29 4.61e-01 -0.079100 7.04e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 83 2.14e-01 0.079000 4.80e-01
PI3K EVENTS IN ERBB2 SIGNALING 15 5.97e-01 -0.078900 7.76e-01
INTRA GOLGI TRAFFIC 43 3.71e-01 0.078900 6.49e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 30 4.55e-01 -0.078900 7.01e-01
IRON UPTAKE AND TRANSPORT 52 3.26e-01 -0.078800 5.98e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 180 6.87e-02 0.078700 2.57e-01
HIV ELONGATION ARREST AND RECOVERY 32 4.41e-01 -0.078700 6.95e-01
CHROMOSOME MAINTENANCE 103 1.70e-01 -0.078400 4.25e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 5.44e-01 -0.078300 7.49e-01
MEIOTIC SYNAPSIS 41 3.88e-01 -0.077900 6.60e-01
NUCLEOBASE CATABOLISM 32 4.48e-01 -0.077500 7.00e-01
SIGNALING BY FGFR 74 2.51e-01 -0.077200 5.31e-01
CELL CYCLE MITOTIC 480 3.87e-03 -0.077200 2.70e-02
REGULATION OF FZD BY UBIQUITINATION 20 5.51e-01 -0.077100 7.50e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 1.97e-01 0.077000 4.57e-01
RHOF GTPASE CYCLE 40 4.00e-01 0.076900 6.66e-01
SYNTHESIS OF PA 30 4.67e-01 -0.076800 7.05e-01
RHOQ GTPASE CYCLE 58 3.12e-01 0.076700 5.93e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 5.84e-01 -0.076600 7.70e-01
RAF ACTIVATION 34 4.39e-01 -0.076600 6.93e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 26 5.00e-01 -0.076500 7.22e-01
LDL CLEARANCE 16 5.99e-01 -0.075900 7.79e-01
GAP JUNCTION TRAFFICKING AND REGULATION 33 4.54e-01 -0.075400 7.01e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 94 2.07e-01 0.075300 4.70e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 11 6.66e-01 -0.075100 8.28e-01
SIGNALING BY NOTCH1 75 2.62e-01 -0.075000 5.45e-01
RHO GTPASES ACTIVATE FORMINS 121 1.55e-01 -0.074800 4.01e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 2.38e-01 -0.074500 5.16e-01
SIGNALING BY NOTCH2 33 4.62e-01 -0.074000 7.04e-01
METABOLISM OF FOLATE AND PTERINES 15 6.20e-01 -0.073900 7.97e-01
DEATH RECEPTOR SIGNALLING 133 1.42e-01 0.073800 3.82e-01
SIGNALING BY FGFR2 63 3.15e-01 -0.073200 5.94e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 286 3.40e-02 -0.073000 1.52e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 108 1.97e-01 0.071900 4.57e-01
CILIUM ASSEMBLY 192 8.76e-02 -0.071600 2.87e-01
NUCLEAR SIGNALING BY ERBB4 31 4.91e-01 -0.071400 7.21e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 17 6.10e-01 -0.071400 7.88e-01
NEDDYLATION 219 6.95e-02 -0.071300 2.58e-01
PEPTIDE LIGAND BINDING RECEPTORS 118 1.82e-01 -0.071100 4.40e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 4.55e-01 0.070900 7.01e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 6.84e-01 0.070900 8.35e-01
P75NTR SIGNALS VIA NF KB 16 6.24e-01 -0.070900 7.98e-01
G ALPHA S SIGNALLING EVENTS 107 2.07e-01 0.070600 4.70e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 51 3.84e-01 -0.070400 6.60e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 31 5.00e-01 -0.070000 7.22e-01
RET SIGNALING 38 4.57e-01 0.069800 7.01e-01
HOMOLOGY DIRECTED REPAIR 108 2.11e-01 -0.069700 4.77e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 4.82e-01 0.069600 7.18e-01
CELL CYCLE 598 3.79e-03 -0.069500 2.67e-02
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 5.17e-01 -0.069500 7.35e-01
PYRIMIDINE CATABOLISM 11 6.90e-01 -0.069400 8.38e-01
SARS COV 1 INFECTION 48 4.07e-01 -0.069200 6.72e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 5.26e-01 -0.069200 7.38e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 4.80e-01 0.069000 7.16e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 5.20e-01 0.069000 7.38e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 3.05e-01 -0.068900 5.86e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 62 3.50e-01 -0.068700 6.21e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 6.94e-01 0.068500 8.39e-01
COMMON PATHWAY OF FIBRIN CLOT FORMATION 11 6.94e-01 0.068500 8.39e-01
RAC3 GTPASE CYCLE 89 2.65e-01 0.068400 5.46e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 3.66e-01 -0.068100 6.42e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS 27 5.43e-01 -0.067600 7.49e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 4.44e-01 -0.067500 6.96e-01
REGULATION OF BETA CELL DEVELOPMENT 30 5.22e-01 -0.067500 7.38e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 2.78e-01 -0.067400 5.62e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 5.10e-01 0.067300 7.29e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS 42 4.52e-01 -0.067100 7.01e-01
REGULATION OF IFNA SIGNALING 12 6.88e-01 0.067000 8.36e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 20 6.07e-01 -0.066500 7.85e-01
GPCR LIGAND BINDING 286 5.34e-02 -0.066500 2.20e-01
ACTIVATION OF MATRIX METALLOPROTEINASES 14 6.67e-01 -0.066400 8.28e-01
HCMV LATE EVENTS 66 3.51e-01 -0.066300 6.23e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 5.27e-01 0.065700 7.38e-01
RHO GTPASES ACTIVATE WASPS AND WAVES 36 4.96e-01 0.065600 7.21e-01
SNRNP ASSEMBLY 51 4.18e-01 -0.065500 6.78e-01
MITOTIC TELOPHASE CYTOKINESIS 13 6.84e-01 0.065100 8.35e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING 24 5.83e-01 0.064800 7.69e-01
INTERFERON SIGNALING 168 1.48e-01 -0.064800 3.86e-01
IRAK1 RECRUITS IKK COMPLEX 14 6.77e-01 -0.064400 8.30e-01
GLUCONEOGENESIS 27 5.63e-01 -0.064300 7.59e-01
RND1 GTPASE CYCLE 38 4.93e-01 0.064300 7.21e-01
MICRORNA MIRNA BIOGENESIS 24 5.87e-01 -0.064100 7.71e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 3.85e-01 0.063900 6.60e-01
CIRCADIAN CLOCK 68 3.63e-01 0.063800 6.40e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 7.16e-01 -0.063300 8.46e-01
SIGNALING BY BRAF AND RAF FUSIONS 60 3.97e-01 0.063200 6.63e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 6.72e-01 -0.063100 8.28e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 3.94e-01 -0.063100 6.60e-01
G ALPHA 12 13 SIGNALLING EVENTS 74 3.49e-01 0.063000 6.20e-01
GRB2 EVENTS IN ERBB2 SIGNALING 15 6.73e-01 -0.063000 8.28e-01
HCMV INFECTION 104 2.68e-01 -0.062900 5.50e-01
RAC2 GTPASE CYCLE 86 3.16e-01 0.062600 5.94e-01
SIGNALING BY FGFR IN DISEASE 56 4.18e-01 -0.062500 6.78e-01
CARGO CONCENTRATION IN THE ER 30 5.55e-01 0.062300 7.52e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 5.09e-01 -0.061900 7.29e-01
SIGNALING BY NTRK2 TRKB 23 6.09e-01 0.061700 7.87e-01
NUCLEAR ENVELOPE NE REASSEMBLY 64 3.95e-01 -0.061500 6.60e-01
FGFR1 MUTANT RECEPTOR ACTIVATION 27 5.80e-01 0.061500 7.69e-01
FRS MEDIATED FGFR3 SIGNALING 16 6.71e-01 0.061400 8.28e-01
ACTIVATION OF SMO 16 6.73e-01 -0.061000 8.28e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 6.37e-01 -0.060900 8.08e-01
INFLAMMASOMES 19 6.46e-01 -0.060900 8.14e-01
MHC CLASS II ANTIGEN PRESENTATION 103 2.86e-01 0.060900 5.68e-01
COSTIMULATION BY THE CD28 FAMILY 52 4.48e-01 0.060900 7.00e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 7.04e-01 -0.060800 8.40e-01
ACYL CHAIN REMODELLING OF PS 14 6.94e-01 0.060700 8.39e-01
GAB1 SIGNALOSOME 14 6.94e-01 -0.060700 8.39e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 14 6.95e-01 0.060500 8.39e-01
INTERLEUKIN 15 SIGNALING 13 7.06e-01 0.060400 8.40e-01
KERATAN SULFATE BIOSYNTHESIS 26 5.95e-01 0.060300 7.75e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT 11 7.30e-01 0.060200 8.57e-01
CHROMATIN MODIFYING ENZYMES 219 1.30e-01 0.059400 3.65e-01
G ALPHA Z SIGNALLING EVENTS 45 4.92e-01 -0.059200 7.21e-01
GPVI MEDIATED ACTIVATION CASCADE 31 5.68e-01 -0.059200 7.64e-01
VITAMIN B5 PANTOTHENATE METABOLISM 14 7.02e-01 0.059000 8.40e-01
PEROXISOMAL PROTEIN IMPORT 59 4.35e-01 -0.058800 6.89e-01
ARACHIDONIC ACID METABOLISM 38 5.34e-01 0.058300 7.44e-01
INOSITOL PHOSPHATE METABOLISM 47 4.91e-01 0.058100 7.21e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 20 6.53e-01 -0.058100 8.19e-01
THE PHOTOTRANSDUCTION CASCADE 22 6.38e-01 0.058000 8.08e-01
POTENTIAL THERAPEUTICS FOR SARS 77 3.81e-01 -0.057800 6.60e-01
FRS MEDIATED FGFR4 SIGNALING 15 7.03e-01 -0.056900 8.40e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 26 6.16e-01 0.056800 7.93e-01
RND3 GTPASE CYCLE 38 5.48e-01 -0.056400 7.49e-01
RHOV GTPASE CYCLE 32 5.82e-01 0.056300 7.69e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 7.59e-01 0.056000 8.75e-01
SUMOYLATION OF SUMOYLATION PROTEINS 33 5.79e-01 0.055800 7.69e-01
CRMPS IN SEMA3A SIGNALING 16 6.99e-01 0.055800 8.40e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 6.44e-01 0.055700 8.12e-01
MAPK FAMILY SIGNALING CASCADES 289 1.04e-01 -0.055700 3.18e-01
DEADENYLATION OF MRNA 25 6.31e-01 0.055600 8.04e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 4.97e-01 0.054500 7.21e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 7.44e-01 0.054500 8.66e-01
AGGREPHAGY 35 5.78e-01 -0.054400 7.69e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 6.39e-01 -0.054100 8.09e-01
KILLING MECHANISMS 11 7.57e-01 0.053800 8.75e-01
IRE1ALPHA ACTIVATES CHAPERONES 50 5.10e-01 -0.053800 7.29e-01
LYSINE CATABOLISM 11 7.58e-01 0.053700 8.75e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 6.56e-01 -0.053700 8.21e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 5.25e-01 -0.053600 7.38e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 6.79e-01 0.053500 8.32e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 5.91e-01 -0.053300 7.73e-01
IRS MEDIATED SIGNALLING 40 5.61e-01 0.053100 7.59e-01
REGULATION OF KIT SIGNALING 16 7.14e-01 -0.052800 8.45e-01
RNA POLYMERASE II TRANSCRIPTION 1092 3.43e-03 -0.052800 2.45e-02
RND2 GTPASE CYCLE 38 5.76e-01 0.052500 7.69e-01
TRAF6 MEDIATED NF KB ACTIVATION 22 6.71e-01 -0.052400 8.28e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 7.01e-01 -0.052300 8.40e-01
GAP JUNCTION DEGRADATION 11 7.64e-01 -0.052200 8.78e-01
HCMV EARLY EVENTS 81 4.18e-01 -0.052100 6.78e-01
DEVELOPMENTAL BIOLOGY 827 1.19e-02 -0.051700 6.75e-02
LAMININ INTERACTIONS 30 6.26e-01 0.051400 8.00e-01
COHESIN LOADING ONTO CHROMATIN 10 7.80e-01 0.051000 8.91e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM 549 4.17e-02 -0.051000 1.78e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 5.42e-01 -0.050900 7.49e-01
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 7.80e-01 0.050900 8.91e-01
INNATE IMMUNE SYSTEM 786 1.66e-02 -0.050500 8.69e-02
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 3.95e-01 -0.050300 6.60e-01
TRANSCRIPTIONAL REGULATION BY TP53 342 1.12e-01 -0.050100 3.34e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 7.02e-01 -0.049400 8.40e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 26 6.64e-01 -0.049200 8.26e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 6.77e-01 0.049200 8.30e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 12 7.69e-01 0.049000 8.81e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 5.49e-01 0.048600 7.49e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 74 4.70e-01 0.048500 7.09e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.75e-01 0.048400 8.30e-01
CELLULAR SENESCENCE 143 3.20e-01 -0.048200 5.96e-01
GLUTAMATE AND GLUTAMINE METABOLISM 13 7.65e-01 -0.048000 8.78e-01
SEMA4D IN SEMAPHORIN SIGNALING 24 6.85e-01 0.047800 8.35e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 3.91e-01 0.047800 6.60e-01
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 7.77e-01 0.047300 8.89e-01
PARASITE INFECTION 56 5.47e-01 0.046500 7.49e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 36 6.30e-01 -0.046400 8.04e-01
OTHER SEMAPHORIN INTERACTIONS 19 7.27e-01 0.046400 8.55e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 6.55e-01 0.046300 8.21e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 7.01e-01 -0.046300 8.40e-01
SIGNALING BY PDGF 57 5.46e-01 0.046300 7.49e-01
ONCOGENIC MAPK SIGNALING 77 4.86e-01 0.046000 7.21e-01
LATE ENDOSOMAL MICROAUTOPHAGY 32 6.54e-01 -0.045800 8.19e-01
SIGNALING BY INSULIN RECEPTOR 64 5.26e-01 0.045800 7.38e-01
SIGNALING BY ERYTHROPOIETIN 24 7.00e-01 0.045500 8.40e-01
SELECTIVE AUTOPHAGY 72 5.06e-01 -0.045300 7.28e-01
PI 3K CASCADE FGFR2 17 7.47e-01 0.045100 8.70e-01
BIOLOGICAL OXIDATIONS 127 3.82e-01 -0.044900 6.60e-01
N GLYCAN ANTENNAE ELONGATION 15 7.64e-01 -0.044800 8.78e-01
EGFR DOWNREGULATION 28 6.82e-01 -0.044800 8.34e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 7.18e-01 -0.044500 8.46e-01
DISEASES OF METABOLISM 200 2.79e-01 0.044500 5.63e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 367 1.45e-01 -0.044400 3.86e-01
DUAL INCISION IN GG NER 41 6.24e-01 -0.044300 7.98e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION 35 6.53e-01 0.043900 8.19e-01
VEGFR2 MEDIATED CELL PROLIFERATION 19 7.41e-01 0.043800 8.64e-01
RECEPTOR MEDIATED MITOPHAGY 11 8.02e-01 -0.043700 8.98e-01
INSULIN RECEPTOR RECYCLING 20 7.36e-01 -0.043600 8.60e-01
TOLL LIKE RECEPTOR CASCADES 135 3.87e-01 0.043100 6.60e-01
PYRUVATE METABOLISM 27 6.99e-01 0.043000 8.40e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 5.86e-01 -0.042900 7.71e-01
DERMATAN SULFATE BIOSYNTHESIS 11 8.06e-01 0.042900 8.99e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 30 6.86e-01 0.042600 8.36e-01
INTEGRIN SIGNALING 24 7.18e-01 -0.042600 8.46e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 45 6.24e-01 -0.042200 7.98e-01
CHAPERONE MEDIATED AUTOPHAGY 21 7.40e-01 -0.041900 8.64e-01
GLYCOLYSIS 67 5.55e-01 0.041800 7.52e-01
NCAM1 INTERACTIONS 42 6.41e-01 -0.041600 8.09e-01
FCERI MEDIATED CA 2 MOBILIZATION 26 7.14e-01 -0.041600 8.45e-01
EPIGENETIC REGULATION OF GENE EXPRESSION 104 4.66e-01 -0.041400 7.05e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 6.83e-01 0.041100 8.35e-01
RHO GTPASE CYCLE 427 1.47e-01 0.041000 3.86e-01
RHOC GTPASE CYCLE 73 5.46e-01 0.040900 7.49e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 6.64e-01 -0.040800 8.26e-01
PURINE CATABOLISM 16 7.78e-01 -0.040700 8.90e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 7.05e-01 -0.040700 8.40e-01
ORGANELLE BIOGENESIS AND MAINTENANCE 284 2.44e-01 -0.040200 5.24e-01
INTEGRATION OF ENERGY METABOLISM 99 4.90e-01 0.040200 7.21e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 5.83e-01 -0.040000 7.69e-01
COLLAGEN CHAIN TRIMERIZATION 40 6.62e-01 -0.039900 8.26e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 5.50e-01 0.039700 7.50e-01
SPHINGOLIPID METABOLISM 80 5.43e-01 -0.039300 7.49e-01
SHC1 EVENTS IN ERBB4 SIGNALING 13 8.06e-01 -0.039300 8.99e-01
SUMOYLATION OF RNA BINDING PROTEINS 45 6.49e-01 0.039300 8.17e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 21 7.58e-01 0.038900 8.75e-01
NEGATIVE REGULATION OF MAPK PATHWAY 42 6.64e-01 -0.038700 8.26e-01
ACYL CHAIN REMODELLING OF PE 16 7.89e-01 -0.038600 8.94e-01
G1 S SPECIFIC TRANSCRIPTION 27 7.29e-01 -0.038500 8.57e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 6.75e-01 -0.038300 8.30e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 146 4.31e-01 -0.037800 6.86e-01
INTRINSIC PATHWAY FOR APOPTOSIS 52 6.38e-01 -0.037700 8.08e-01
PROTEIN METHYLATION 17 7.88e-01 -0.037700 8.93e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 120 4.80e-01 -0.037400 7.16e-01
GROWTH HORMONE RECEPTOR SIGNALING 21 7.68e-01 0.037200 8.81e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 94 5.35e-01 -0.037100 7.44e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 15 8.06e-01 0.036600 8.99e-01
AMINO ACIDS REGULATE MTORC1 51 6.53e-01 0.036400 8.19e-01
ADAPTIVE IMMUNE SYSTEM 606 1.30e-01 -0.036100 3.65e-01
SIGNALING BY GPCR 503 1.68e-01 0.036000 4.23e-01
METABOLISM OF CARBOHYDRATES 262 3.17e-01 0.036000 5.94e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 75 5.91e-01 -0.035900 7.73e-01
DNA DOUBLE STRAND BREAK REPAIR 137 4.79e-01 -0.035100 7.16e-01
DNA DAMAGE RECOGNITION IN GG NER 38 7.09e-01 0.035000 8.42e-01
RHOG GTPASE CYCLE 73 6.07e-01 0.034900 7.85e-01
MET PROMOTES CELL MOTILITY 39 7.07e-01 0.034800 8.40e-01
ER TO GOLGI ANTEROGRADE TRANSPORT 141 4.76e-01 0.034800 7.14e-01
INTERLEUKIN 10 SIGNALING 20 7.88e-01 -0.034800 8.93e-01
MITOTIC PROMETAPHASE 179 4.25e-01 -0.034600 6.80e-01
PRE NOTCH EXPRESSION AND PROCESSING 64 6.33e-01 -0.034500 8.06e-01
PEXOPHAGY 11 8.43e-01 0.034400 9.25e-01
GOLGI TO ER RETROGRADE TRANSPORT 120 5.20e-01 -0.034000 7.38e-01
DNA DAMAGE BYPASS 48 6.97e-01 -0.032500 8.40e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 21 7.99e-01 0.032200 8.97e-01
VIRAL MESSENGER RNA SYNTHESIS 42 7.21e-01 0.031800 8.49e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 5.82e-01 0.031400 7.69e-01
ONCOGENE INDUCED SENESCENCE 32 7.59e-01 -0.031400 8.75e-01
APOPTOTIC EXECUTION PHASE 45 7.16e-01 -0.031300 8.46e-01
SIGNALING BY INTERLEUKINS 346 3.22e-01 -0.031000 5.97e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 8.15e-01 0.031000 9.05e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 8.53e-01 0.030900 9.30e-01
VISUAL PHOTOTRANSDUCTION 64 6.70e-01 0.030800 8.28e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 88 6.19e-01 -0.030700 7.96e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 7.87e-01 -0.030600 8.93e-01
MTOR SIGNALLING 40 7.40e-01 0.030300 8.64e-01
REGULATION OF TP53 ACTIVITY 151 5.27e-01 0.029900 7.38e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 7.54e-01 0.029700 8.74e-01
PKA MEDIATED PHOSPHORYLATION OF CREB 19 8.23e-01 -0.029700 9.09e-01
METABOLISM OF FAT SOLUBLE VITAMINS 35 7.64e-01 0.029400 8.78e-01
TRNA PROCESSING 105 6.04e-01 0.029300 7.83e-01
REGULATED PROTEOLYSIS OF P75NTR 12 8.60e-01 -0.029300 9.34e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 7.96e-01 0.029300 8.95e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 8.61e-01 -0.029300 9.34e-01
FLT3 SIGNALING IN DISEASE 28 7.93e-01 0.028700 8.95e-01
CITRIC ACID CYCLE TCA CYCLE 22 8.16e-01 0.028700 9.05e-01
O LINKED GLYCOSYLATION OF MUCINS 42 7.48e-01 0.028600 8.70e-01
EICOSANOID LIGAND BINDING RECEPTORS 10 8.76e-01 -0.028400 9.45e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 8.77e-01 0.028200 9.45e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 7.52e-01 -0.028200 8.73e-01
PLASMA LIPOPROTEIN ASSEMBLY 13 8.61e-01 0.028100 9.34e-01
DNA STRAND ELONGATION 32 7.83e-01 0.028100 8.93e-01
DARPP 32 EVENTS 23 8.17e-01 -0.027800 9.06e-01
OPIOID SIGNALLING 86 6.60e-01 0.027500 8.25e-01
KERATAN SULFATE KERATIN METABOLISM 32 7.88e-01 0.027500 8.93e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 7.32e-01 -0.026500 8.58e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 8.65e-01 0.026300 9.38e-01
FCGR3A MEDIATED IL10 SYNTHESIS 33 7.95e-01 -0.026200 8.95e-01
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 10 8.87e-01 -0.025900 9.49e-01
MITOCHONDRIAL BIOGENESIS 92 6.69e-01 0.025800 8.28e-01
FGFRL1 MODULATION OF FGFR1 SIGNALING 10 8.88e-01 0.025800 9.49e-01
RNA POLYMERASE III CHAIN ELONGATION 18 8.50e-01 0.025800 9.28e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 283 4.60e-01 0.025600 7.04e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 8.80e-01 -0.025300 9.45e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS 62 7.32e-01 0.025200 8.58e-01
SIGNALING BY MET 75 7.07e-01 -0.025100 8.40e-01
RRNA PROCESSING IN THE MITOCHONDRION 10 8.91e-01 0.025100 9.50e-01
ASPARAGINE N LINKED GLYCOSYLATION 284 4.77e-01 -0.024600 7.14e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 53 7.58e-01 0.024500 8.75e-01
FLT3 SIGNALING 36 8.00e-01 0.024400 8.97e-01
GLUCOSE METABOLISM 81 7.04e-01 0.024400 8.40e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 8.68e-01 -0.024000 9.40e-01
LAGGING STRAND SYNTHESIS 20 8.54e-01 -0.023800 9.30e-01
REGULATION OF TNFR1 SIGNALING 34 8.14e-01 0.023400 9.04e-01
RNA POLYMERASE III TRANSCRIPTION 41 8.06e-01 0.022200 8.99e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION 223 5.75e-01 -0.021800 7.69e-01
HEMOSTASIS 476 4.22e-01 0.021500 6.78e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS 50 7.93e-01 -0.021500 8.95e-01
LEISHMANIA INFECTION 201 6.00e-01 -0.021500 7.79e-01
HS GAG BIOSYNTHESIS 30 8.39e-01 -0.021400 9.24e-01
G ALPHA Q SIGNALLING EVENTS 171 6.33e-01 -0.021200 8.06e-01
SUMOYLATION OF DNA REPLICATION PROTEINS 43 8.14e-01 -0.020800 9.04e-01
SHC1 EVENTS IN ERBB2 SIGNALING 21 8.70e-01 0.020600 9.41e-01
REGULATION OF BACH1 ACTIVITY 11 9.06e-01 -0.020600 9.58e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 34 8.36e-01 0.020500 9.21e-01
TRANSLESION SYNTHESIS BY POLH 19 8.78e-01 -0.020300 9.45e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 186 6.34e-01 -0.020200 8.06e-01
MITOTIC PROPHASE 95 7.35e-01 0.020100 8.60e-01
TBC RABGAPS 42 8.23e-01 0.020000 9.09e-01
PROCESSING OF INTRONLESS PRE MRNAS 19 8.82e-01 0.019600 9.46e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 63 7.88e-01 -0.019600 8.93e-01
MTORC1 MEDIATED SIGNALLING 24 8.68e-01 0.019500 9.40e-01
SUMOYLATION OF DNA METHYLATION PROTEINS 16 8.94e-01 -0.019300 9.52e-01
CA2 PATHWAY 56 8.03e-01 0.019300 8.99e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 34 8.47e-01 -0.019100 9.28e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 9.09e-01 0.019100 9.60e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 8.71e-01 0.018400 9.41e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 633 4.37e-01 0.018200 6.90e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 15 9.03e-01 0.018100 9.56e-01
PROCESSING OF SMDT1 16 9.00e-01 -0.018100 9.55e-01
SIGNALING BY FGFR4 34 8.57e-01 -0.017800 9.33e-01
TNF SIGNALING 43 8.40e-01 0.017800 9.24e-01
SHC MEDIATED CASCADE FGFR3 14 9.13e-01 -0.016900 9.61e-01
PI 3K CASCADE FGFR4 13 9.17e-01 -0.016700 9.62e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS 203 6.87e-01 -0.016400 8.36e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 85 7.95e-01 -0.016300 8.95e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 8.28e-01 -0.016300 9.14e-01
SIGNALING BY PDGFR IN DISEASE 20 9.03e-01 0.015700 9.56e-01
HATS ACETYLATE HISTONES 93 7.98e-01 0.015400 8.97e-01
COLLAGEN DEGRADATION 52 8.48e-01 -0.015300 9.28e-01
GLUTATHIONE SYNTHESIS AND RECYCLING 11 9.31e-01 -0.015100 9.71e-01
ERBB2 ACTIVATES PTK6 SIGNALING 12 9.29e-01 0.014800 9.70e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 90 8.09e-01 0.014700 9.02e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 8.72e-01 0.014500 9.42e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 9.16e-01 -0.014400 9.62e-01
VESICLE MEDIATED TRANSPORT 612 5.47e-01 0.014300 7.49e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 170 7.49e-01 0.014200 8.70e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 9.29e-01 0.014200 9.70e-01
REGULATION OF INSULIN SECRETION 71 8.41e-01 0.013700 9.24e-01
DEFECTS IN COBALAMIN B12 METABOLISM 13 9.32e-01 -0.013600 9.71e-01
MEMBRANE TRAFFICKING 580 5.78e-01 0.013600 7.69e-01
RHO GTPASE EFFECTORS 253 7.11e-01 -0.013500 8.43e-01
AUTOPHAGY 139 7.86e-01 -0.013300 8.93e-01
RHOH GTPASE CYCLE 37 8.89e-01 0.013300 9.49e-01
RAB REGULATION OF TRAFFICKING 118 8.10e-01 -0.012800 9.02e-01
SIGNAL TRANSDUCTION BY L1 21 9.21e-01 0.012600 9.65e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 9.34e-01 0.012300 9.71e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 8.83e-01 0.012300 9.46e-01
SIGNALLING TO RAS 19 9.27e-01 0.012100 9.69e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 8.99e-01 -0.012100 9.55e-01
COPI MEDIATED ANTEROGRADE TRANSPORT 91 8.42e-01 0.012100 9.24e-01
GENE SILENCING BY RNA 86 8.51e-01 -0.011800 9.28e-01
CD28 CO STIMULATION 31 9.10e-01 0.011700 9.60e-01
EPH EPHRIN SIGNALING 91 8.50e-01 -0.011500 9.28e-01
INTERLEUKIN 2 FAMILY SIGNALING 33 9.11e-01 0.011200 9.60e-01
FATTY ACID METABOLISM 146 8.19e-01 0.011000 9.07e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 66 8.80e-01 -0.010700 9.45e-01
SIGNALING BY NTRK3 TRKC 16 9.41e-01 0.010600 9.73e-01
FATTY ACYL COA BIOSYNTHESIS 32 9.17e-01 -0.010600 9.62e-01
SIGNALING BY RECEPTOR TYROSINE KINASES 465 7.00e-01 0.010500 8.40e-01
NEGATIVE REGULATION OF MET ACTIVITY 20 9.36e-01 0.010400 9.71e-01
PLATELET ADHESION TO EXPOSED COLLAGEN 12 9.51e-01 0.010300 9.77e-01
EPHRIN SIGNALING 19 9.40e-01 -0.009980 9.73e-01
METABOLISM OF VITAMINS AND COFACTORS 156 8.30e-01 0.009950 9.16e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 8.84e-01 -0.009530 9.47e-01
KINESINS 48 9.10e-01 0.009480 9.60e-01
SIGNALING BY KIT IN DISEASE 20 9.42e-01 0.009470 9.73e-01
AURKA ACTIVATION BY TPX2 71 8.91e-01 -0.009430 9.50e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 26 9.34e-01 0.009320 9.71e-01
SIGNALING BY FGFR3 36 9.24e-01 0.009210 9.67e-01
GLYCOSPHINGOLIPID METABOLISM 38 9.28e-01 -0.008520 9.69e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 8.77e-01 0.008180 9.45e-01
REGULATION OF PTEN GENE TRANSCRIPTION 59 9.16e-01 -0.007970 9.62e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 9.00e-01 -0.007920 9.55e-01
ACTIVATION OF BH3 ONLY PROTEINS 30 9.41e-01 -0.007770 9.73e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 24 9.50e-01 -0.007450 9.77e-01
ERKS ARE INACTIVATED 13 9.63e-01 0.007380 9.81e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 9.64e-01 0.006950 9.81e-01
CELL CELL COMMUNICATION 106 9.02e-01 0.006930 9.56e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 9.50e-01 0.006890 9.77e-01
FRS MEDIATED FGFR2 SIGNALING 19 9.59e-01 0.006810 9.81e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 9.65e-01 0.006530 9.81e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 9.59e-01 0.006440 9.81e-01
METABOLISM OF LIPIDS 619 7.91e-01 0.006260 8.95e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 9.61e-01 0.005860 9.81e-01
P75NTR REGULATES AXONOGENESIS 10 9.76e-01 0.005530 9.87e-01
TRNA PROCESSING IN THE NUCLEUS 56 9.44e-01 -0.005390 9.75e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 51 9.48e-01 -0.005330 9.77e-01
SIGNALING BY SCF KIT 41 9.54e-01 0.005260 9.79e-01
DEADENYLATION DEPENDENT MRNA DECAY 55 9.48e-01 -0.005050 9.77e-01
RESOLUTION OF ABASIC SITES AP SITES 38 9.59e-01 0.004840 9.81e-01
TRIGLYCERIDE BIOSYNTHESIS 10 9.79e-01 0.004800 9.88e-01
POLO LIKE KINASE MEDIATED EVENTS 14 9.76e-01 0.004620 9.87e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 105 9.35e-01 -0.004590 9.71e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 9.67e-01 0.004510 9.82e-01
DNA REPAIR 293 8.96e-01 -0.004430 9.54e-01
POST TRANSLATIONAL PROTEIN MODIFICATION 1225 7.96e-01 -0.004430 8.95e-01
SIGNALING BY VEGF 102 9.39e-01 -0.004360 9.73e-01
PLATELET AGGREGATION PLUG FORMATION 32 9.70e-01 -0.003890 9.84e-01
INTEGRIN CELL SURFACE INTERACTIONS 74 9.57e-01 -0.003640 9.81e-01
FOXO MEDIATED TRANSCRIPTION 58 9.64e-01 0.003440 9.81e-01
DISEASES OF PROGRAMMED CELL DEATH 55 9.65e-01 0.003440 9.81e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH 62 9.65e-01 0.003260 9.81e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 87 9.65e-01 0.002730 9.81e-01
SIGNALING BY FGFR1 44 9.76e-01 0.002590 9.87e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 9.71e-01 0.002480 9.84e-01
SIGNALING BY FGFR1 IN DISEASE 34 9.80e-01 -0.002420 9.88e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 9.80e-01 -0.002410 9.88e-01
SIGNALLING TO ERKS 33 9.84e-01 0.001980 9.90e-01
SEMAPHORIN INTERACTIONS 64 9.79e-01 -0.001950 9.88e-01
EXTENSION OF TELOMERES 49 9.81e-01 -0.001920 9.88e-01
TIE2 SIGNALING 17 9.89e-01 0.001900 9.93e-01
POLYMERASE SWITCHING 14 9.92e-01 -0.001610 9.94e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 9.96e-01 0.000752 9.98e-01
SUMOYLATION 165 9.87e-01 -0.000746 9.92e-01
SIGNALING BY FLT3 FUSION PROTEINS 19 9.97e-01 -0.000532 9.98e-01
G ALPHA I SIGNALLING EVENTS 207 9.90e-01 0.000485 9.94e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 9.98e-01 -0.000321 9.98e-01


Detailed Gene set reports



INCRETIN SYNTHESIS SECRETION AND INACTIVATION

INCRETIN SYNTHESIS SECRETION AND INACTIVATION
443
set INCRETIN SYNTHESIS SECRETION AND INACTIVATION
setSize 13
pANOVA 0.000296
s.dist -0.58
p.adjustANOVA 0.00339



Top enriched genes

Top 20 genes
GeneID Gene Rank
Isl1 -7810
Sec11a -7800
Gng13 -7337
Sec11c -7082
Grp -6663
Spcs2 -6336
Spcs3 -6189
Tcf7l2 -5682
Spcs1 -4766
Pax6 -4664
Dpp4 -3478
Ctnnb1 -3040
Pcsk1 2114

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Isl1 -7810
Sec11a -7800
Gng13 -7337
Sec11c -7082
Grp -6663
Spcs2 -6336
Spcs3 -6189
Tcf7l2 -5682
Spcs1 -4766
Pax6 -4664
Dpp4 -3478
Ctnnb1 -3040
Pcsk1 2114


SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1

SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
1057
set SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1
setSize 12
pANOVA 0.00086
s.dist -0.556
p.adjustANOVA 0.00854



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sec11a -7800
Gng13 -7337
Sec11c -7082
Grp -6663
Spcs2 -6336
Spcs3 -6189
Tcf7l2 -5682
Spcs1 -4766
Pax6 -4664
Dpp4 -3478
Ctnnb1 -3040
Pcsk1 2114

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sec11a -7800
Gng13 -7337
Sec11c -7082
Grp -6663
Spcs2 -6336
Spcs3 -6189
Tcf7l2 -5682
Spcs1 -4766
Pax6 -4664
Dpp4 -3478
Ctnnb1 -3040
Pcsk1 2114


HSF1 ACTIVATION

HSF1 ACTIVATION
434
set HSF1 ACTIVATION
setSize 27
pANOVA 8.9e-07
s.dist -0.546
p.adjustANOVA 3.09e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Serpinh1 -8963
Hspa1b -8925
Dnajb1 -8909
Hsph1 -8886
Hspa1a -8857
Fkbp4 -8855
Hspb1 -8786
Hsp90aa1 -8747
Ptges3 -8484
Hsp90ab1 -8390
Rpa1 -7213
Dedd2 -7114
Mrpl18 -6432
Hsbp1 -6298
Cryba4 -5971
Dnajb6 -5640
Hsf1 -5595
Rpa2 -5048
Eef1a1 -4814
Ubb -4777

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Serpinh1 -8963
Hspa1b -8925
Dnajb1 -8909
Hsph1 -8886
Hspa1a -8857
Fkbp4 -8855
Hspb1 -8786
Hsp90aa1 -8747
Ptges3 -8484
Hsp90ab1 -8390
Rpa1 -7213
Dedd2 -7114
Mrpl18 -6432
Hsbp1 -6298
Cryba4 -5971
Dnajb6 -5640
Hsf1 -5595
Rpa2 -5048
Eef1a1 -4814
Ubb -4777
Ywhae -4529
Vcp -1938
Tnfrsf21 -484
Rpa3 945
Rln1 4395
Hdac6 5084
Col4a6 8449


ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
82
set ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
setSize 10
pANOVA 0.00478
s.dist -0.515
p.adjustANOVA 0.0325



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspa5 -8934
Ddit3 -8873
Xbp1 -8778
Hsp90b1 -8470
Calr -8053
Nfyb -7194
Atf4 -5578
Nfya -1797
Nfyc 2139
Atf6 8296

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspa5 -8934
Ddit3 -8873
Xbp1 -8778
Hsp90b1 -8470
Calr -8053
Nfyb -7194
Atf4 -5578
Nfya -1797
Nfyc 2139
Atf6 8296


ATTENUATION PHASE

ATTENUATION PHASE
84
set ATTENUATION PHASE
setSize 25
pANOVA 8.44e-06
s.dist -0.515
p.adjustANOVA 0.000189



Top enriched genes

Top 20 genes
GeneID Gene Rank
Serpinh1 -8963
Hspa1b -8925
Dnajb1 -8909
Hsph1 -8886
Hspa1a -8857
Fkbp4 -8855
Hspb1 -8786
Hsp90aa1 -8747
Ptges3 -8484
Hsp90ab1 -8390
Hspa8 -8371
Dedd2 -7114
Mrpl18 -6432
Hsbp1 -6298
Cryba4 -5971
Dnajb6 -5640
Hsf1 -5595
Ubb -4777
Hspa1l -2421
Tnfrsf21 -484

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Serpinh1 -8963
Hspa1b -8925
Dnajb1 -8909
Hsph1 -8886
Hspa1a -8857
Fkbp4 -8855
Hspb1 -8786
Hsp90aa1 -8747
Ptges3 -8484
Hsp90ab1 -8390
Hspa8 -8371
Dedd2 -7114
Mrpl18 -6432
Hsbp1 -6298
Cryba4 -5971
Dnajb6 -5640
Hsf1 -5595
Ubb -4777
Hspa1l -2421
Tnfrsf21 -484
Ep300 1462
Hspa2 2346
Rln1 4395
Crebbp 6396
Col4a6 8449


EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION
306
set EUKARYOTIC TRANSLATION ELONGATION
setSize 87
pANOVA 2.5e-16
s.dist -0.508
p.adjustANOVA 5.91e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Fau -6452

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Fau -6452
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Rps17 -5738
Rpl21 -5718
Rpl37a -5672
Rpl7 -5582
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Rpl23 -5330
Rps18 -5277
Rps20 -5257
Eef1g -5256
Rpl37 -5237
Rps16 -5226
Rpl10a -5182
Rpl32 -5161
Eef1b2 -5136
Rps21 -4966
Eef1a1 -4814
Rpl3 -4794
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Rpl36 -4525
Rplp0 -4097
Eef1d -4059
Rpl8 -4033
Rps14 -4004
Rplp1 -3988
Rpl18 -3948
Rpl7a -3883
Rps4x -3874
Rpl30 -3803
Rps28 -3120
Rps13 -2924
Eef1a2 -2828
Uba52 -2734
Rps2 -2210
Rplp2 -1540
Rpl12 -1415
Rpl28 -1401
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Rps29 -259
Rps15a 399
Rpl22 2503
Eef2 3684
Rpl5 6278
Rpl10 8261


NEUROTOXICITY OF CLOSTRIDIUM TOXINS

NEUROTOXICITY OF CLOSTRIDIUM TOXINS
621
set NEUROTOXICITY OF CLOSTRIDIUM TOXINS
setSize 10
pANOVA 0.00576
s.dist 0.504
p.adjustANOVA 0.0372



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sv2c 8175
Vamp1 6699
Syt1 6183
Sv2b 5353
Stx1b 4779
Syt2 3856
Vamp2 3219
Snap25 2565
Stx1a 667
Sv2a 498

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sv2c 8175
Vamp1 6699
Syt1 6183
Sv2b 5353
Stx1b 4779
Syt2 3856
Vamp2 3219
Snap25 2565
Stx1a 667
Sv2a 498


COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS
172
set COMPLEX I BIOGENESIS
setSize 56
pANOVA 8.77e-11
s.dist -0.501
p.adjustANOVA 5.76e-09



Top enriched genes

Top 20 genes
GeneID Gene Rank
mt-Nd6 -8802
mt-Nd2 -8617
mt-Nd3 -8399
Ndufaf2 -8280
mt-Nd4 -8047
Ndufaf5 -7997
Ndufaf4 -7906
mt-Nd5 -7797
mt-Nd1 -7586
Ndufa6 -7485
Ndufaf6 -7045
Ndufb5 -6979
Tmem186 -6968
Ndufv2 -6747
Ndufc1 -6577
Acad9 -6205
Ndufb2 -5991
Ndufb8 -5944
Tmem126b -5928
Ndufs5 -5901

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
mt-Nd6 -8802
mt-Nd2 -8617
mt-Nd3 -8399
Ndufaf2 -8280
mt-Nd4 -8047
Ndufaf5 -7997
Ndufaf4 -7906
mt-Nd5 -7797
mt-Nd1 -7586
Ndufa6 -7485
Ndufaf6 -7045
Ndufb5 -6979
Tmem186 -6968
Ndufv2 -6747
Ndufc1 -6577
Acad9 -6205
Ndufb2 -5991
Ndufb8 -5944
Tmem126b -5928
Ndufs5 -5901
Ndufb7 -5832
Ndufaf1 -5819
Ndufb6 -5617
Ndufb1 -5610
Ndufb9 -5554
Ndufb11 -5506
Nubpl -5459
Ndufs4 -5453
Ndufb3 -5347
Ndufa7 -5328
Ndufa11 -5284
Timmdc1 -5194
Ndufa2 -4952
Ndufb4 -4836
Ndufc2 -4687
Ndufa8 -4285
Ndufs6 -4125
Ndufs8 -3266
Ndufb10 -3215
Ndufv3 -3043
Ndufa3 -2882
Ndufa5 -2863
Ndufa9 -2263
Ndufa1 -1801
Ndufa10 -1508
Ndufa12 -1388
Ndufs3 -1228
Ecsit -1156
Ndufs7 -1125
Ndufv1 -937
Ndufaf7 -936
Ndufab1 -800
Ndufa13 -554
Ndufs2 484
Ndufaf3 2156
Ndufs1 3474


NITRIC OXIDE STIMULATES GUANYLATE CYCLASE

NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
630
set NITRIC OXIDE STIMULATES GUANYLATE CYCLASE
setSize 21
pANOVA 9.99e-05
s.dist 0.49
p.adjustANOVA 0.00139



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pde1a 8170
Pde2a 8151
Kcnma1 7305
Irag1 6527
Nos2 6519
Itpr1 6448
Pde9a 6422
Nos1 6341
Prkg1 6273
Kcnmb4 5894
Gucy1a1 5825
Pde11a 5655
Pde10a 5262
Pde1b 5227
Gucy1b1 3822
Pde5a 3744
Nos3 3283
Gucy1a2 1831
Kcnmb2 -641
Kcnmb1 -7801

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pde1a 8170
Pde2a 8151
Kcnma1 7305
Irag1 6527
Nos2 6519
Itpr1 6448
Pde9a 6422
Nos1 6341
Prkg1 6273
Kcnmb4 5894
Gucy1a1 5825
Pde11a 5655
Pde10a 5262
Pde1b 5227
Gucy1b1 3822
Pde5a 3744
Nos3 3283
Gucy1a2 1831
Kcnmb2 -641
Kcnmb1 -7801
Prkg2 -8674


COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING

COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
181
set COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING
setSize 26
pANOVA 1.81e-05
s.dist -0.486
p.adjustANOVA 0.00035



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cct6a -8719
Vbp1 -8711
Cct4 -8600
Pfdn4 -8596
Cct3 -8472
Tubb2b -8362
Cct7 -8082
Cct5 -7980
Cct2 -7639
Tcp1 -6822
Tubb4b -6225
Pfdn5 -6102
Tuba1a -5910
Pfdn1 -5324
Tubb2a -4830
Pfdn6 -4828
Cct8 -4816
Pfdn2 -4239
Tuba1b -3302
Tubb3 -2952

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a -8719
Vbp1 -8711
Cct4 -8600
Pfdn4 -8596
Cct3 -8472
Tubb2b -8362
Cct7 -8082
Cct5 -7980
Cct2 -7639
Tcp1 -6822
Tubb4b -6225
Pfdn5 -6102
Tuba1a -5910
Pfdn1 -5324
Tubb2a -4830
Pfdn6 -4828
Cct8 -4816
Pfdn2 -4239
Tuba1b -3302
Tubb3 -2952
Tubb4a -2063
Tuba4a -520
Actb 188
Tubb6 373
Tuba8 8044
Tuba1c 8476


ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE

ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE
9
set ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE
setSize 17
pANOVA 0.000528
s.dist 0.486
p.adjustANOVA 0.00564



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc18a3 8193
Slc5a7 7967
Chat 7695
Cplx1 6715
Syt1 6183
Ppfia4 6170
Rims1 6058
Unc13b 5558
Ppfia2 3818
Vamp2 3219
Ppfia1 2673
Snap25 2565
Stxbp1 1550
Stx1a 667
Ppfia3 569
Tspoap1 -373
Rab3a -655

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc18a3 8193
Slc5a7 7967
Chat 7695
Cplx1 6715
Syt1 6183
Ppfia4 6170
Rims1 6058
Unc13b 5558
Ppfia2 3818
Vamp2 3219
Ppfia1 2673
Snap25 2565
Stxbp1 1550
Stx1a 667
Ppfia3 569
Tspoap1 -373
Rab3a -655


CHOLESTEROL BIOSYNTHESIS

CHOLESTEROL BIOSYNTHESIS
148
set CHOLESTEROL BIOSYNTHESIS
setSize 24
pANOVA 3.84e-05
s.dist -0.485
p.adjustANOVA 0.00063



Top enriched genes

Top 20 genes
GeneID Gene Rank
Idi1 -8905
Msmo1 -8816
Sqle -8815
Cyp51 -8456
Acat3 -8369
Mvd -8188
Sc5d -8185
Hmgcs1 -7923
Fdps -7793
Mvk -7773
Ebp -6416
Hsd17b7 -6386
Fdft1 -6244
Ggps1 -6129
Pmvk -4568
Lbr -4403
Nsdhl -3436
Lss -2755
Dhcr24 -2128
Hmgcr 1279

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Idi1 -8905
Msmo1 -8816
Sqle -8815
Cyp51 -8456
Acat3 -8369
Mvd -8188
Sc5d -8185
Hmgcs1 -7923
Fdps -7793
Mvk -7773
Ebp -6416
Hsd17b7 -6386
Fdft1 -6244
Ggps1 -6129
Pmvk -4568
Lbr -4403
Nsdhl -3436
Lss -2755
Dhcr24 -2128
Hmgcr 1279
Arv1 2846
Dhcr7 4058
Tm7sf2 5062
Plpp6 5401


RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
841
set RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize 95
pANOVA 4.52e-16
s.dist -0.482
p.adjustANOVA 8.91e-14



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ddit3 -8873
Atf3 -8436
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Eif2s1 -7333
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ddit3 -8873
Atf3 -8436
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Eif2s1 -7333
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Impact -6590
Rps3a1 -6556
Cebpg -6496
Fau -6452
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Rps17 -5738
Rpl21 -5718
Rpl37a -5672
Rpl7 -5582
Atf4 -5578
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Rpl23 -5330
Rps18 -5277
Rps20 -5257
Rpl37 -5237
Rps16 -5226
Rpl10a -5182
Rpl32 -5161
Rps21 -4966
Eif2s2 -4953
Rpl3 -4794
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Rpl36 -4525
Rplp0 -4097
Rpl8 -4033
Rps14 -4004
Rplp1 -3988
Rpl18 -3948
Rpl7a -3883
Rps4x -3874
Rpl30 -3803
Trib3 -3166
Rps28 -3120
Rps13 -2924
Uba52 -2734
Atf2 -2467
Rps2 -2210
Rplp2 -1540
Rpl12 -1415
Rpl28 -1401
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Rps29 -259
Eif2s3x 18
Rps15a 399
Cebpb 2021
Rpl22 2503
Asns 4233
Rpl5 6278
Eif2ak4 6628
Gcn1 7143
Rpl10 8261


SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
1014
set SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize 106
pANOVA 1.9e-17
s.dist -0.478
p.adjustANOVA 7.48e-15



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sec11a -7800
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Rpl26 -7286
Srp14 -7210
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Sec11c -7082
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sec11a -7800
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Rpl26 -7286
Srp14 -7210
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Sec11c -7082
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Fau -6452
Spcs2 -6336
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Spcs3 -6189
Ssr3 -6185
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Srp19 -5747
Rps17 -5738
Rpl21 -5718
Rpl37a -5672
Rpl7 -5582
Tram1 -5545
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Rpl23 -5330
Rps18 -5277
Rps20 -5257
Rpl37 -5237
Rps16 -5226
Srp9 -5217
Rpl10a -5182
Rpl32 -5161
Ssr4 -5160
Rps21 -4966
Rpl3 -4794
Spcs1 -4766
Rpn1 -4732
Srprb -4700
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Rpl36 -4525
Rplp0 -4097
Rpl8 -4033
Rps14 -4004
Rplp1 -3988
Sec61b -3987
Rpl18 -3948
Rpl7a -3883
Rps4x -3874
Rpl30 -3803
Ddost -3644
Ssr2 -3395
Sec61g -3212
Rps28 -3120
Rps13 -2924
Uba52 -2734
Rps2 -2210
Sec61a1 -1917
Rplp2 -1540
Rpl12 -1415
Rpl28 -1401
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Rps29 -259
Rps15a 399
Rpn2 610
Srp68 1093
Ssr1 1530
Srp54a 2064
Rpl22 2503
Srpr 2632
Sec61a2 2848
Srp72 4040
Rpl5 6278
Rpl10 8261


CGMP EFFECTS

CGMP EFFECTS
144
set CGMP EFFECTS
setSize 15
pANOVA 0.00177
s.dist 0.466
p.adjustANOVA 0.0153



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pde1a 8170
Pde2a 8151
Kcnma1 7305
Irag1 6527
Itpr1 6448
Pde9a 6422
Prkg1 6273
Kcnmb4 5894
Pde11a 5655
Pde10a 5262
Pde1b 5227
Pde5a 3744
Kcnmb2 -641
Kcnmb1 -7801
Prkg2 -8674

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pde1a 8170
Pde2a 8151
Kcnma1 7305
Irag1 6527
Itpr1 6448
Pde9a 6422
Prkg1 6273
Kcnmb4 5894
Pde11a 5655
Pde10a 5262
Pde1b 5227
Pde5a 3744
Kcnmb2 -641
Kcnmb1 -7801
Prkg2 -8674


FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC

FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
341
set FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC
setSize 19
pANOVA 0.00074
s.dist -0.447
p.adjustANOVA 0.00747



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cct6a -8719
Cct4 -8600
Cct3 -8472
Tubb2b -8362
Cct7 -8082
Cct5 -7980
Cct2 -7639
Tcp1 -6822
Tubb4b -6225
Tuba1a -5910
Tubb2a -4830
Cct8 -4816
Tuba1b -3302
Tubb3 -2952
Tubb4a -2063
Tuba4a -520
Tubb6 373
Tuba8 8044
Tuba1c 8476

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a -8719
Cct4 -8600
Cct3 -8472
Tubb2b -8362
Cct7 -8082
Cct5 -7980
Cct2 -7639
Tcp1 -6822
Tubb4b -6225
Tuba1a -5910
Tubb2a -4830
Cct8 -4816
Tuba1b -3302
Tubb3 -2952
Tubb4a -2063
Tuba4a -520
Tubb6 373
Tuba8 8044
Tuba1c 8476


REDUCTION OF CYTOSOLIC CA LEVELS

REDUCTION OF CYTOSOLIC CA LEVELS
787
set REDUCTION OF CYTOSOLIC CA LEVELS
setSize 11
pANOVA 0.0104
s.dist 0.446
p.adjustANOVA 0.0623



Top enriched genes

Top 20 genes
GeneID Gene Rank
Atp2b1 7624
Atp2b4 7525
Atp2a3 7380
Slc8a2 7173
Atp2b2 6848
Slc8a3 5990
Atp2b3 5886
Slc8a1 1694
Atp2a2 -2163
Calm1 -3498
Sri -3863

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Atp2b1 7624
Atp2b4 7525
Atp2a3 7380
Slc8a2 7173
Atp2b2 6848
Slc8a3 5990
Atp2b3 5886
Slc8a1 1694
Atp2a2 -2163
Calm1 -3498
Sri -3863


ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
28
set ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
setSize 59
pANOVA 3.28e-09
s.dist -0.445
p.adjustANOVA 1.8e-07



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif3j2 -8498
Rps23 -7621
Eif3a -7614
Rps8 -7336
Eif2s1 -7333
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Eif4a2 -6837
Eif3g -6727
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Eif3k -6484
Eif4a1 -6470
Fau -6452
Eif3h -6311
Rps7 -6226
Rps15 -6157

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif3j2 -8498
Rps23 -7621
Eif3a -7614
Rps8 -7336
Eif2s1 -7333
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Eif4a2 -6837
Eif3g -6727
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Eif3k -6484
Eif4a1 -6470
Fau -6452
Eif3h -6311
Rps7 -6226
Rps15 -6157
Rps3 -6040
Rps27 -5938
Rps10 -5925
Rps26 -5809
Rps17 -5738
Eif3i -5680
Eif1ax -5511
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rps18 -5277
Rps20 -5257
Rps16 -5226
Rps21 -4966
Eif2s2 -4953
Rps5 -4675
Rps6 -4661
Pabpc1 -4581
Eif3e -4358
Rps14 -4004
Rps4x -3874
Eif3m -3404
Eif4e -3136
Rps28 -3120
Rps13 -2924
Rps2 -2210
Eif3f -1564
Eif3j1 -1026
Eif4ebp1 -975
Eif3d -274
Rps29 -259
Eif2s3x 18
Rps15a 399
Eif3b 1266
Eif3l 1306
Eif4g1 3758
Eif4h 4068
Eif3c 5492
Eif4b 7706


ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES

ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
75
set ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES
setSize 10
pANOVA 0.0148
s.dist 0.445
p.adjustANOVA 0.0809



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mbtps1 8232
Angptl4 7492
Furin 7476
Creb3l3 7315
Pcsk5 5812
Lmf1 5802
Lpl 3697
Mbtps2 1558
Pcsk6 -5185
Lmf2 -5383

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mbtps1 8232
Angptl4 7492
Furin 7476
Creb3l3 7315
Pcsk5 5812
Lmf1 5802
Lpl 3697
Mbtps2 1558
Pcsk6 -5185
Lmf2 -5383


LONG TERM POTENTIATION

LONG TERM POTENTIATION
522
set LONG TERM POTENTIATION
setSize 23
pANOVA 0.000245
s.dist 0.442
p.adjustANOVA 0.00289



Top enriched genes

Top 20 genes
GeneID Gene Rank
Grin2a 8460
Grin2c 8431
Nrgn 8390
Camk2b 8091
Grin2b 7962
Camk2a 7879
Gria1 6723
Dlg2 6327
Dlg4 5548
Actn2 5460
Erbb4 5208
Camk2d 3958
Grin1 3087
Gria2 2478
Dlg3 2466
Lrrc7 2033
Src 1697
Nefl -170
Nrg1 -429
Grin2d -693

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grin2a 8460
Grin2c 8431
Nrgn 8390
Camk2b 8091
Grin2b 7962
Camk2a 7879
Gria1 6723
Dlg2 6327
Dlg4 5548
Actn2 5460
Erbb4 5208
Camk2d 3958
Grin1 3087
Gria2 2478
Dlg3 2466
Lrrc7 2033
Src 1697
Nefl -170
Nrg1 -429
Grin2d -693
Camk2g -2707
Dlg1 -2759
Calm1 -3498


TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS

TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS
1111
set TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS
setSize 17
pANOVA 0.00166
s.dist 0.44
p.adjustANOVA 0.0148



Top enriched genes

Top 20 genes
GeneID Gene Rank
Grip1 7822
Prkcb 7805
Prkca 7669
Gria3 7618
Ap2b1 6804
Gria1 6723
Prkcg 5625
Nsf 4890
Ap2a1 4290
Grip2 4139
Gria2 2478
Pick1 1581
Tspan7 803
Ap2m1 557
Gria4 -890
Ap2a2 -1871
Ap2s1 -4173

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grip1 7822
Prkcb 7805
Prkca 7669
Gria3 7618
Ap2b1 6804
Gria1 6723
Prkcg 5625
Nsf 4890
Ap2a1 4290
Grip2 4139
Gria2 2478
Pick1 1581
Tspan7 803
Ap2m1 557
Gria4 -890
Ap2a2 -1871
Ap2s1 -4173


SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS

SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS
1004
set SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS
setSize 11
pANOVA 0.0117
s.dist -0.439
p.adjustANOVA 0.0669



Top enriched genes

Top 20 genes
GeneID Gene Rank
Snrpf -7226
Snrpd3 -6649
Lsm11 -6397
Slbp -6299
Snrpe -5664
Snrpb -4087
Lsm10 -2996
Ncbp2 -2209
Snrpg -1906
Zfp473 -1716
Ncbp1 509

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Snrpf -7226
Snrpd3 -6649
Lsm11 -6397
Slbp -6299
Snrpe -5664
Snrpb -4087
Lsm10 -2996
Ncbp2 -2209
Snrpg -1906
Zfp473 -1716
Ncbp1 509


UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION

UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION
1161
set UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION
setSize 21
pANOVA 0.000524
s.dist 0.437
p.adjustANOVA 0.00564



Top enriched genes

Top 20 genes
GeneID Gene Rank
Grin2a 8460
Grin2c 8431
Camk2b 8091
Grin2b 7962
Camk2a 7879
Gria3 7618
Gria1 6723
Dlg2 6327
Dlg4 5548
Actn2 5460
Camk2d 3958
Grin1 3087
Gria2 2478
Dlg3 2466
Lrrc7 2033
Nefl -170
Grin2d -693
Gria4 -890
Camk2g -2707
Dlg1 -2759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grin2a 8460
Grin2c 8431
Camk2b 8091
Grin2b 7962
Camk2a 7879
Gria3 7618
Gria1 6723
Dlg2 6327
Dlg4 5548
Actn2 5460
Camk2d 3958
Grin1 3087
Gria2 2478
Dlg3 2466
Lrrc7 2033
Nefl -170
Grin2d -693
Gria4 -890
Camk2g -2707
Dlg1 -2759
Calm1 -3498


RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT
838
set RESPIRATORY ELECTRON TRANSPORT
setSize 102
pANOVA 2.5e-14
s.dist -0.437
p.adjustANOVA 3.28e-12



Top enriched genes

Top 20 genes
GeneID Gene Rank
mt-Nd6 -8802
mt-Nd2 -8617
mt-Nd3 -8399
Ndufaf2 -8280
mt-Nd4 -8047
Ndufaf5 -7997
Ndufaf4 -7906
mt-Nd5 -7797
mt-Co3 -7668
mt-Co2 -7592
mt-Nd1 -7586
Ndufa6 -7485
Coq10b -7404
mt-Co1 -7188
Ndufaf6 -7045
Ndufb5 -6979
Tmem186 -6968
Cox16 -6867
mt-Cytb -6802
Ndufv2 -6747

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
mt-Nd6 -8802
mt-Nd2 -8617
mt-Nd3 -8399
Ndufaf2 -8280
mt-Nd4 -8047
Ndufaf5 -7997
Ndufaf4 -7906
mt-Nd5 -7797
mt-Co3 -7668
mt-Co2 -7592
mt-Nd1 -7586
Ndufa6 -7485
Coq10b -7404
mt-Co1 -7188
Ndufaf6 -7045
Ndufb5 -6979
Tmem186 -6968
Cox16 -6867
mt-Cytb -6802
Ndufv2 -6747
Ndufc1 -6577
Cox11 -6479
Uqcr10 -6314
Acad9 -6205
Uqcrh -6107
Ndufa4 -6059
Ndufb2 -5991
Ndufb8 -5944
Tmem126b -5928
Ndufs5 -5901
Ndufb7 -5832
Ndufaf1 -5819
Cox19 -5623
Ndufb6 -5617
Ndufb1 -5610
Ndufb9 -5554
Ndufb11 -5506
Nubpl -5459
Ndufs4 -5453
Cycs -5431
Cox6c -5366
Ndufb3 -5347
Ndufa7 -5328
Ndufa11 -5284
Timmdc1 -5194
Cox7c -5170
Uqcrq -5122
Cox7a2l -5118
Ndufa2 -4952
Cox7b -4937
Sco2 -4847
Ndufb4 -4836
Ndufc2 -4687
Cox5a -4660
Ndufa8 -4285
Uqcrc2 -4226
Ndufs6 -4125
Sdhc -4031
Uqcrb -3805
Cox4i1 -3773
Uqcrc1 -3688
Cox6b1 -3552
Cox18 -3386
Sdhb -3338
Ndufs8 -3266
Ndufb10 -3215
Cox8a -3134
Ndufv3 -3043
Cox5b -2962
Ndufa3 -2882
Ndufa5 -2863
Cyc1 -2440
Etfdh -2320
Ndufa9 -2263
Uqcr11 -2258
Taco1 -2193
Uqcrfs1 -2059
Cox6a1 -1961
Ndufa1 -1801
Sdhd -1687
Etfb -1615
Ndufa10 -1508
Ndufa12 -1388
Ndufs3 -1228
Ecsit -1156
Cox20 -1148
Ndufs7 -1125
Coq10a -963
Ndufv1 -937
Ndufaf7 -936
Etfa -835
Ndufab1 -800
Ndufa13 -554
Surf1 -326
Ndufs2 484
Cox14 759
Sdha 1760
Ndufaf3 2156
Trap1 3342
Ndufs1 3474
Lrpprc 5296
Sco1 6559


COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING

COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING
180
set COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING
setSize 35
pANOVA 8.65e-06
s.dist -0.434
p.adjustANOVA 0.000189



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cct6a -8719
Cct4 -8600
Gng5 -8487
Cct3 -8472
Cct7 -8082
Cct5 -7980
Gna14 -7943
Gng11 -7683
Cct2 -7639
Gng13 -7337
Gng10 -6910
Gng2 -6879
Tcp1 -6822
Rgs7 -6598
Gngt2 -6500
Csnk2a1 -6471
Gnb4 -6235
Gnaq -5480
Cct8 -4816
Gng3 -4364

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cct6a -8719
Cct4 -8600
Gng5 -8487
Cct3 -8472
Cct7 -8082
Cct5 -7980
Gna14 -7943
Gng11 -7683
Cct2 -7639
Gng13 -7337
Gng10 -6910
Gng2 -6879
Tcp1 -6822
Rgs7 -6598
Gngt2 -6500
Csnk2a1 -6471
Gnb4 -6235
Gnaq -5480
Cct8 -4816
Gng3 -4364
Rgs11 -3585
Gna11 -3107
Gna15 -2602
Gnb5 -2168
Gnb2 -2000
Gnb1 -1413
Rgs6 -874
Pdcl -395
Gng8 -185
Csnk2b -168
Gng4 1097
Csnk2a2 1549
Gng12 1797
Rgs9 6688
Gng7 6965


VOLTAGE GATED POTASSIUM CHANNELS

VOLTAGE GATED POTASSIUM CHANNELS
1174
set VOLTAGE GATED POTASSIUM CHANNELS
setSize 39
pANOVA 4.31e-06
s.dist 0.425
p.adjustANOVA 0.000121



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kcnf1 8468
Kcna5 8440
Kcnd1 8141
Kcng1 8072
Kcnh3 8018
Kcng2 7849
Kcnh8 7748
Kcnab2 7592
Kcnq5 7555
Kcns2 7490
Kcnab3 7401
Kcnab1 7219
Kcnv1 6837
Kcnq3 6767
Kcnq2 6412
Kcnh7 6320
Kcnb1 5744
Kcnd3 5156
Kcna1 5098
Kcnc1 4914

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kcnf1 8468
Kcna5 8440
Kcnd1 8141
Kcng1 8072
Kcnh3 8018
Kcng2 7849
Kcnh8 7748
Kcnab2 7592
Kcnq5 7555
Kcns2 7490
Kcnab3 7401
Kcnab1 7219
Kcnv1 6837
Kcnq3 6767
Kcnq2 6412
Kcnh7 6320
Kcnb1 5744
Kcnd3 5156
Kcna1 5098
Kcnc1 4914
Kcnh1 4798
Kcnc2 4352
Kcnh6 4244
Kcnc4 3861
Kcna2 3842
Kcnh4 1902
Kcnh5 1813
Kcns1 1324
Kcnd2 820
Kcnq4 122
Kcng4 -51
Kcnc3 -681
Kcnh2 -2652
Kcna3 -2904
Kcnb2 -3221
Kcna4 -3835
Kcna6 -5517
Kcnq1 -5542
Kcns3 -7345


GLYCOGEN STORAGE DISEASES

GLYCOGEN STORAGE DISEASES
392
set GLYCOGEN STORAGE DISEASES
setSize 12
pANOVA 0.0108
s.dist -0.425
p.adjustANOVA 0.0635



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ppp1r3c -8232
G6pc3 -8009
Gbe1 -7817
Gyg -7417
Rps27a -6969
Ubb -4777
Gaa -4751
Uba52 -2734
Nhlrc1 -1594
Ubc -1368
Gys1 -859
Epm2a 7324

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ppp1r3c -8232
G6pc3 -8009
Gbe1 -7817
Gyg -7417
Rps27a -6969
Ubb -4777
Gaa -4751
Uba52 -2734
Nhlrc1 -1594
Ubc -1368
Gys1 -859
Epm2a 7324


SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES

SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
1038
set SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES
setSize 29
pANOVA 7.53e-05
s.dist -0.425
p.adjustANOVA 0.00111



Top enriched genes

Top 20 genes
GeneID Gene Rank
Uchl3 -8664
Ube2g1 -8540
Uba6 -8424
Ube2r2 -8423
Ube2q2 -8239
Ube2a -7963
Ube2e3 -7698
Ube2b -7423
Ube2w -7079
Rps27a -6969
Ube2d1 -6673
Ube2e1 -5840
Ube2k -5688
Ubb -4777
Ube2s -4597
Usp5 -4082
Ube2d2a -3441
Usp7 -2796
Uba52 -2734
Usp9x -2601

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Uchl3 -8664
Ube2g1 -8540
Uba6 -8424
Ube2r2 -8423
Ube2q2 -8239
Ube2a -7963
Ube2e3 -7698
Ube2b -7423
Ube2w -7079
Rps27a -6969
Ube2d1 -6673
Ube2e1 -5840
Ube2k -5688
Ubb -4777
Ube2s -4597
Usp5 -4082
Ube2d2a -3441
Usp7 -2796
Uba52 -2734
Usp9x -2601
Ube2l3 -2221
Cdc34 -1886
Ubc -1368
Ube2h -334
Ube2g2 -207
Uba1 1239
Ube2z 1521
Ube2t 5970
Otulin 6027


EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION
307
set EUKARYOTIC TRANSLATION INITIATION
setSize 114
pANOVA 6.04e-15
s.dist -0.423
p.adjustANOVA 8.91e-13



Top enriched genes

Top 20 genes
GeneID Gene Rank
Eif3j2 -8498
Rpl11 -7708
Rps23 -7621
Eif3a -7614
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Eif2s1 -7333
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Eif4a2 -6837
Rpl39 -6805
Eif3g -6727
Rpl17 -6723
Rpl19 -6713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Eif3j2 -8498
Rpl11 -7708
Rps23 -7621
Eif3a -7614
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Eif2s1 -7333
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Eif4a2 -6837
Rpl39 -6805
Eif3g -6727
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Eif3k -6484
Eif4a1 -6470
Fau -6452
Eif3h -6311
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Eif2b2 -6017
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Rps17 -5738
Rpl21 -5718
Eif3i -5680
Rpl37a -5672
Rpl7 -5582
Eif1ax -5511
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Rpl23 -5330
Rps18 -5277
Rps20 -5257
Rpl37 -5237
Rps16 -5226
Rpl10a -5182
Rpl32 -5161
Rps21 -4966
Eif2s2 -4953
Rpl3 -4794
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Pabpc1 -4581
Rpl36 -4525
Eif3e -4358
Rplp0 -4097
Rpl8 -4033
Rps14 -4004
Rplp1 -3988
Rpl18 -3948
Rpl7a -3883
Rps4x -3874
Rpl30 -3803
Eif3m -3404
Eif4e -3136
Rps28 -3120
Rps13 -2924
Uba52 -2734
Rps2 -2210
Eif3f -1564
Rplp2 -1540
Eif5b -1448
Rpl12 -1415
Rpl28 -1401
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Eif3j1 -1026
Eif4ebp1 -975
Eif3d -274
Rps29 -259
Eif2s3x 18
Rps15a 399
Eif3b 1266
Eif3l 1306
Eif2b5 1397
Eif5 2012
Eif2b3 2399
Rpl22 2503
Eif2b1 3257
Eif4g1 3758
Eif4h 4068
Eif3c 5492
Rpl5 6278
Eif4b 7706
Eif2b4 7959
Rpl10 8261


AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA

AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
85
set AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA
setSize 53
pANOVA 1.1e-07
s.dist -0.422
p.adjustANOVA 4.8e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspa1a -8857
Hspb1 -8786
Hspa8 -8371
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Psmc6 -7536
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Psmb1 -6399
Psmb6 -6200

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspa1a -8857
Hspb1 -8786
Hspa8 -8371
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Psmc6 -7536
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Psmb1 -6399
Psmb6 -6200
Psma2 -6169
Psmd10 -5518
Psmd6 -5516
Psme1 -5290
Psmb9 -4797
Ubb -4777
Psmb4 -4713
Pabpc1 -4581
Psmb8 -4445
Psmd11 -4311
Psmb5 -3923
Psmb10 -3806
Psmd4 -3790
Psmc5 -3637
Psmc1 -3600
Psmc3 -3073
Uba52 -2734
Psma5 -2323
Psmc4 -1980
Ubc -1368
Psmb7 -1285
Psmd8 -1101
Psmd9 -960
Psmb2 -709
Psmd13 -469
Psmd3 6
Psmd7 94
Psme3 2393
Psmf1 2577
Hnrnpd 2868
Eif4g1 3758
Psmd2 6444
Psme4 6731


RHOBTB2 GTPASE CYCLE

RHOBTB2 GTPASE CYCLE
863
set RHOBTB2 GTPASE CYCLE
setSize 23
pANOVA 0.000491
s.dist -0.42
p.adjustANOVA 0.00537



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsp90aa1 -8747
Cct6a -8719
Txnl1 -8636
Tra2b -8448
Hsp90ab1 -8390
Cct7 -8082
Cct2 -7639
Phip -7120
Hnrnpc -6170
Rhobtb2 -5762
Tmod3 -5346
Cul3 -5038
Actn1 -4466
Actg1 -2753
Cdc37 -2743
Twf1 -1625
Ddx39b -1194
Msi2 -842
Stk38 -318
Myo6 1081

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsp90aa1 -8747
Cct6a -8719
Txnl1 -8636
Tra2b -8448
Hsp90ab1 -8390
Cct7 -8082
Cct2 -7639
Phip -7120
Hnrnpc -6170
Rhobtb2 -5762
Tmod3 -5346
Cul3 -5038
Actn1 -4466
Actg1 -2753
Cdc37 -2743
Twf1 -1625
Ddx39b -1194
Msi2 -842
Stk38 -318
Myo6 1081
Srrm1 1991
Dbn1 2458
Rbmx 7118


CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX

CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
147
set CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX
setSize 10
pANOVA 0.0223
s.dist -0.417
p.adjustANOVA 0.11



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ywhaq -7442
Chek2 -6324
Chek1 -6321
Ywhab -6041
Ywhah -4995
Ywhae -4529
Wee1 -3670
Sfn -451
Ywhaz 364
Ywhag 735

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ywhaq -7442
Chek2 -6324
Chek1 -6321
Ywhab -6041
Ywhah -4995
Ywhae -4529
Wee1 -3670
Sfn -451
Ywhaz 364
Ywhag 735


EFFECTS OF PIP2 HYDROLYSIS

EFFECTS OF PIP2 HYDROLYSIS
277
set EFFECTS OF PIP2 HYDROLYSIS
setSize 27
pANOVA 0.000177
s.dist 0.417
p.adjustANOVA 0.0022



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rasgrp1 8463
Daglb 8136
Trpc3 7237
Dgkz 7169
Dgke 6963
Prkce 6907
Itpr1 6448
Dgkg 6136
Dgkh 6101
Dagla 5723
Rasgrp2 5523
Itpr3 5255
Dgkd 4810
Dgka 4614
Prkcq 4210
Dgkb 3652
Prkcd 3422
Mgll 3420
Dgki 2434
Dgkq 2366

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rasgrp1 8463
Daglb 8136
Trpc3 7237
Dgkz 7169
Dgke 6963
Prkce 6907
Itpr1 6448
Dgkg 6136
Dgkh 6101
Dagla 5723
Rasgrp2 5523
Itpr3 5255
Dgkd 4810
Dgka 4614
Prkcq 4210
Dgkb 3652
Prkcd 3422
Mgll 3420
Dgki 2434
Dgkq 2366
Dgkk 1818
Prkch -1728
Itpr2 -2124
Abhd12 -3156
Trpc7 -3402
Trpc6 -3864
Abhd6 -3891


REGULATION OF EXPRESSION OF SLITS AND ROBOS

REGULATION OF EXPRESSION OF SLITS AND ROBOS
794
set REGULATION OF EXPRESSION OF SLITS AND ROBOS
setSize 161
pANOVA 1.06e-19
s.dist -0.415
p.adjustANOVA 6.27e-17



Top enriched genes

Top 20 genes
GeneID Gene Rank
Magohb -8868
Rbm8a -8725
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Isl1 -7810
Rpl11 -7708
Rps23 -7621
Psmc6 -7536
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Magoh -7335
Rpl26 -7286
Cul2 -7279
Eloc -7250
Rpl24 -7198
Rps25 -7195
Lhx3 -7168

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Magohb -8868
Rbm8a -8725
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Isl1 -7810
Rpl11 -7708
Rps23 -7621
Psmc6 -7536
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Magoh -7335
Rpl26 -7286
Cul2 -7279
Eloc -7250
Rpl24 -7198
Rps25 -7195
Lhx3 -7168
Rps12 -7156
Psmc2 -7131
Psmd14 -7122
Rps24 -6975
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Rpl22l1 -6859
Rpl39 -6805
Psmd1 -6789
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Psma3 -6623
Usp33 -6601
Sem1 -6563
Rps3a1 -6556
Psma6 -6549
Psme2 -6497
Fau -6452
Psmb1 -6399
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Psmb6 -6200
Psma2 -6169
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Rps17 -5738
Rpl21 -5718
Rpl37a -5672
Gspt2 -5653
Upf3b -5630
Rpl7 -5582
Psmd10 -5518
Psmd6 -5516
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Rpl23 -5330
Psme1 -5290
Rps18 -5277
Rps20 -5257
Rpl37 -5237
Rps16 -5226
Rpl10a -5182
Rpl32 -5161
Elob -5042
Rps21 -4966
Etf1 -4927
Psmb9 -4797
Rpl3 -4794
Ubb -4777
Psmb4 -4713
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Pabpc1 -4581
Rpl36 -4525
Slit2 -4481
Psmb8 -4445
Psmd11 -4311
Rplp0 -4097
Rpl8 -4033
Rps14 -4004
Rplp1 -3988
Rpl18 -3948
Psmb5 -3923
Rpl7a -3883
Rps4x -3874
Psmb10 -3806
Rpl30 -3803
Psmd4 -3790
Upf2 -3777
Psmc5 -3637
Psmc1 -3600
Col4a5 -3522
Rps28 -3120
Psmc3 -3073
Robo1 -2972
Rps13 -2924
Uba52 -2734
Rnps1 -2644
Psma5 -2323
Rps2 -2210
Ncbp2 -2209
Psmc4 -1980
Rplp2 -1540
Rpl12 -1415
Rpl28 -1401
Ubc -1368
Psmb7 -1285
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Psmd8 -1101
Psmd9 -960
Dag1 -957
Msi1 -814
Psmb2 -709
Psmd13 -469
Rps29 -259
Psmd3 6
Psmd7 94
Rbx1 254
Rps15a 399
Ncbp1 509
Ldb1 1371
Eif4a3 1717
Lhx9 1718
Gspt1 1743
Zswim8 2125
Psme3 2393
Rpl22 2503
Psmf1 2577
Eif4g1 3758
Slit1 4222
Casc3 5442
Rpl5 6278
Psmd2 6444
Psme4 6731
Robo3 6841
Upf3a 6897
Robo2 7529
Rpl10 8261
Lhx2 8445


TRAFFICKING OF AMPA RECEPTORS

TRAFFICKING OF AMPA RECEPTORS
1110
set TRAFFICKING OF AMPA RECEPTORS
setSize 31
pANOVA 7.78e-05
s.dist 0.41
p.adjustANOVA 0.00113



Top enriched genes

Top 20 genes
GeneID Gene Rank
Camk2b 8091
Camk2a 7879
Grip1 7822
Prkcb 7805
Prkca 7669
Gria3 7618
Cacng8 7544
Ap2b1 6804
Gria1 6723
Akap5 6720
Epb41l1 6521
Cacng3 5787
Prkcg 5625
Dlg4 5548
Mdm2 4949
Nsf 4890
Ap2a1 4290
Grip2 4139
Camk2d 3958
Gria2 2478

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Camk2b 8091
Camk2a 7879
Grip1 7822
Prkcb 7805
Prkca 7669
Gria3 7618
Cacng8 7544
Ap2b1 6804
Gria1 6723
Akap5 6720
Epb41l1 6521
Cacng3 5787
Prkcg 5625
Dlg4 5548
Mdm2 4949
Nsf 4890
Ap2a1 4290
Grip2 4139
Camk2d 3958
Gria2 2478
Pick1 1581
Myo6 1081
Tspan7 803
Ap2m1 557
Gria4 -890
Ap2a2 -1871
Camk2g -2707
Dlg1 -2759
Ap2s1 -4173
Cacng2 -4848
Cacng4 -5166


SCF SKP2 MEDIATED DEGRADATION OF P27 P21

SCF SKP2 MEDIATED DEGRADATION OF P27 P21
912
set SCF SKP2 MEDIATED DEGRADATION OF P27 P21
setSize 60
pANOVA 5.02e-08
s.dist -0.407
p.adjustANOVA 2.47e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ccnd1 -8489
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Ccne2 -8004
Psmd12 -7812
Skp1 -7696
Ccna1 -7547
Psmc6 -7536
Cks1b -7205
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ccnd1 -8489
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Ccne2 -8004
Psmd12 -7812
Skp1 -7696
Ccna1 -7547
Psmc6 -7536
Cks1b -7205
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Cdkn1b -6455
Psmb1 -6399
Psmb6 -6200
Psma2 -6169
Psmd10 -5518
Psmd6 -5516
Psme1 -5290
Psmb9 -4797
Cdk2 -4790
Ubb -4777
Psmb4 -4713
Psmb8 -4445
Psmd11 -4311
Cdk4 -3955
Psmb5 -3923
Psmb10 -3806
Psmd4 -3790
Psmc5 -3637
Psmc1 -3600
Psmc3 -3073
Uba52 -2734
Psma5 -2323
Ccna2 -2156
Psmc4 -1980
Ubc -1368
Psmb7 -1285
Psmd8 -1101
Psmd9 -960
Psmb2 -709
Psmd13 -469
Psmd3 6
Psmd7 94
Ptk6 357
Skp2 1496
Psme3 2393
Psmf1 2577
Ccne1 4569
Cul1 5941
Psmd2 6444
Cdkn1a 7257


SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM
915
set SELENOAMINO ACID METABOLISM
setSize 110
pANOVA 3.4e-13
s.dist -0.402
p.adjustANOVA 3.34e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
Dars -8650
Gsr -8534
Hnmt -8159
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Aimp2 -7104
Txnrd1 -7012
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Dars -8650
Gsr -8534
Hnmt -8159
Rpl11 -7708
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Aimp2 -7104
Txnrd1 -7012
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Fau -6452
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Rps17 -5738
Rpl21 -5718
Rpl37a -5672
Sephs2 -5621
Rpl7 -5582
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Papss2 -5334
Rpl23 -5330
Rps18 -5277
Rps20 -5257
Rpl37 -5237
Rps16 -5226
Rpl10a -5182
Rpl32 -5161
Rps21 -4966
Rpl3 -4794
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Rpl36 -4525
Eef1e1 -4455
Kars -4270
Rplp0 -4097
Rpl8 -4033
Rps14 -4004
Rplp1 -3988
Rpl18 -3948
Rpl7a -3883
Rps4x -3874
Rpl30 -3803
Secisbp2 -3220
Rps28 -3120
Aimp1 -3085
Rps13 -2924
Uba52 -2734
Rps2 -2210
Rars -1631
Rplp2 -1540
Cth -1423
Rpl12 -1415
Rpl28 -1401
Ahcy -1310
Qars -1292
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Pstk -1081
Sars -588
Rps29 -259
Papss1 169
Rps15a 399
Inmt 482
Mars1 1183
Nnmt 2106
Rpl22 2503
Gnmt 3157
Scly 3531
Iars 3800
Eefsec 4448
Rpl5 6278
Sepsecs 7338
Lars 7807
Cbs 7892
Eprs 8243
Rpl10 8261


STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS

STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS
1016
set STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS
setSize 10
pANOVA 0.028
s.dist 0.401
p.adjustANOVA 0.132



Top enriched genes

Top 20 genes
GeneID Gene Rank
Bcl2l1 7588
Stat5a 7340
Cdkn1a 7257
Ptpn11 7155
Pim1 3119
Flt3 2865
Nox4 1526
Stat5b 335
Grb2 -921
Gab2 -3280

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bcl2l1 7588
Stat5a 7340
Cdkn1a 7257
Ptpn11 7155
Pim1 3119
Flt3 2865
Nox4 1526
Stat5b 335
Grb2 -921
Gab2 -3280


ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
40
set ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12
setSize 19
pANOVA 0.00248
s.dist -0.401
p.adjustANOVA 0.0196



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng5 -8487
Gnai1 -8311
Gng11 -7683
Gng13 -7337
Gng10 -6910
Gng2 -6879
Gngt2 -6500
Gnb4 -6235
Gnai2 -5305
Gng3 -4364
P2ry12 -4332
Gnai3 -2476
Gnb5 -2168
Gnb2 -2000
Gnb1 -1413
Gng8 -185
Gng4 1097
Gng12 1797
Gng7 6965

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng5 -8487
Gnai1 -8311
Gng11 -7683
Gng13 -7337
Gng10 -6910
Gng2 -6879
Gngt2 -6500
Gnb4 -6235
Gnai2 -5305
Gng3 -4364
P2ry12 -4332
Gnai3 -2476
Gnb5 -2168
Gnb2 -2000
Gnb1 -1413
Gng8 -185
Gng4 1097
Gng12 1797
Gng7 6965


GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION

GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION
369
set GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION
setSize 19
pANOVA 0.00249
s.dist 0.401
p.adjustANOVA 0.0196



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc6a1 7904
Cplx1 6715
Slc32a1 6480
Slc6a13 6375
Gad1 6214
Syt1 6183
Slc6a12 6157
Rims1 6058
Gad2 4846
Dnajc5 3788
Abat 3356
Vamp2 3219
Aldh5a1 3218
Snap25 2565
Stxbp1 1550
Stx1a 667
Rab3a -655
Slc6a11 -3724
Hspa8 -8371

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc6a1 7904
Cplx1 6715
Slc32a1 6480
Slc6a13 6375
Gad1 6214
Syt1 6183
Slc6a12 6157
Rims1 6058
Gad2 4846
Dnajc5 3788
Abat 3356
Vamp2 3219
Aldh5a1 3218
Snap25 2565
Stxbp1 1550
Stx1a 667
Rab3a -655
Slc6a11 -3724
Hspa8 -8371


SIGNALING BY HIPPO

SIGNALING BY HIPPO
966
set SIGNALING BY HIPPO
setSize 20
pANOVA 0.002
s.dist -0.399
p.adjustANOVA 0.0166



Top enriched genes

Top 20 genes
GeneID Gene Rank
Amotl2 -8930
Wwtr1 -8746
Wwc1 -8592
Tjp2 -8464
Yap1 -7838
Casp3 -7787
Amot -7034
Stk3 -6995
Amotl1 -6394
Ywhab -6041
Tjp1 -5599
Ywhae -4529
Sav1 -3646
Stk4 -3450
Lats1 86
Mob1b 592
Dvl2 2182
Lats2 2834
Mob1a 5891
Nphp4 8319

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Amotl2 -8930
Wwtr1 -8746
Wwc1 -8592
Tjp2 -8464
Yap1 -7838
Casp3 -7787
Amot -7034
Stk3 -6995
Amotl1 -6394
Ywhab -6041
Tjp1 -5599
Ywhae -4529
Sav1 -3646
Stk4 -3450
Lats1 86
Mob1b 592
Dvl2 2182
Lats2 2834
Mob1a 5891
Nphp4 8319


G PROTEIN ACTIVATION

G PROTEIN ACTIVATION
358
set G PROTEIN ACTIVATION
setSize 22
pANOVA 0.00125
s.dist -0.397
p.adjustANOVA 0.0118



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gng5 -8487
Gna14 -7943
Gng11 -7683
Gng13 -7337
Gng10 -6910
Gng2 -6879
Gngt2 -6500
Gnb4 -6235
Pomc -6154
Gnaq -5480
Gng3 -4364
Pdyn -4151
Gna11 -3107
Gna15 -2602
Gnb5 -2168
Gnb2 -2000
Oprm1 -1470
Gnb1 -1413
Gng8 -185
Gng4 1097

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gng5 -8487
Gna14 -7943
Gng11 -7683
Gng13 -7337
Gng10 -6910
Gng2 -6879
Gngt2 -6500
Gnb4 -6235
Pomc -6154
Gnaq -5480
Gng3 -4364
Pdyn -4151
Gna11 -3107
Gna15 -2602
Gnb5 -2168
Gnb2 -2000
Oprm1 -1470
Gnb1 -1413
Gng8 -185
Gng4 1097
Gng12 1797
Gng7 6965


HEDGEHOG LIGAND BIOGENESIS

HEDGEHOG LIGAND BIOGENESIS
416
set HEDGEHOG LIGAND BIOGENESIS
setSize 61
pANOVA 7.95e-08
s.dist -0.397
p.adjustANOVA 3.76e-06



Top enriched genes

Top 20 genes
GeneID Gene Rank
Notum -8940
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Gpc5 -8079
Psmd12 -7812
Derl2 -7715
Psmc6 -7536
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Adam17 -6621
Sem1 -6563
Psma6 -6549
Shh -6509
Psme2 -6497

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Notum -8940
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Gpc5 -8079
Psmd12 -7812
Derl2 -7715
Psmc6 -7536
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Adam17 -6621
Sem1 -6563
Psma6 -6549
Shh -6509
Psme2 -6497
Psmb1 -6399
Psmb6 -6200
Psma2 -6169
Os9 -5535
Psmd10 -5518
Psmd6 -5516
Psme1 -5290
P4hb -5239
Syvn1 -4895
Psmb9 -4797
Ubb -4777
Psmb4 -4713
Psmb8 -4445
Psmd11 -4311
Psmb5 -3923
Psmb10 -3806
Psmd4 -3790
Psmc5 -3637
Psmc1 -3600
Psmc3 -3073
Uba52 -2734
Erlec1 -2501
Psma5 -2323
Psmc4 -1980
Vcp -1938
Ubc -1368
Psmb7 -1285
Psmd8 -1101
Psmd9 -960
Psmb2 -709
Sel1l -632
Psmd13 -469
Psmd3 6
Psmd7 94
Psme3 2393
Psmf1 2577
Disp2 2722
Hhat 5464
Psmd2 6444
Psme4 6731
Scube2 8271


MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS

MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
570
set MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
setSize 13
pANOVA 0.0133
s.dist -0.397
p.adjustANOVA 0.0745



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fdx1 -8842
Slc25a28 -8219
Fxn -7931
Lyrm4 -7646
Fdxr -5019
Iscu -4427
Glrx5 -3504
Isca2 -1713
Hscb -1351
Nfs1 -773
Fdx2 -485
Slc25a37 268
Isca1 1738

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fdx1 -8842
Slc25a28 -8219
Fxn -7931
Lyrm4 -7646
Fdxr -5019
Iscu -4427
Glrx5 -3504
Isca2 -1713
Hscb -1351
Nfs1 -773
Fdx2 -485
Slc25a37 268
Isca1 1738


PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
738
set PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
setSize 11
pANOVA 0.0233
s.dist 0.395
p.adjustANOVA 0.114



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cacnb3 6899
Cacna1e 6774
Cacna2d3 6369
Cacna1b 5457
Cacnb2 5250
Cacna2d2 4713
Cacnb4 4421
Cacna1a 4144
Cacnb1 1649
Cacng2 -4848
Cacng4 -5166

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cacnb3 6899
Cacna1e 6774
Cacna2d3 6369
Cacna1b 5457
Cacnb2 5250
Cacna2d2 4713
Cacnb4 4421
Cacna1a 4144
Cacnb1 1649
Cacng2 -4848
Cacng4 -5166


PD 1 SIGNALING

PD 1 SIGNALING
685
set PD 1 SIGNALING
setSize 10
pANOVA 0.0316
s.dist 0.393
p.adjustANOVA 0.145



Top enriched genes

Top 20 genes
GeneID Gene Rank
H2-Eb1 8451
H2-Ab1 8374
H2-Aa 8315
Cd4 7561
Ptpn11 7155
Cd247 6302
Cd274 6041
Lck -2803
Csk -8465
Ptpn6 -8713

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
H2-Eb1 8451
H2-Ab1 8374
H2-Aa 8315
Cd4 7561
Ptpn11 7155
Cd247 6302
Cd274 6041
Lck -2803
Csk -8465
Ptpn6 -8713


REGULATION OF RUNX3 EXPRESSION AND ACTIVITY

REGULATION OF RUNX3 EXPRESSION AND ACTIVITY
821
set REGULATION OF RUNX3 EXPRESSION AND ACTIVITY
setSize 53
pANOVA 9.22e-07
s.dist -0.39
p.adjustANOVA 3.11e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Cbfb -8474
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Psmc6 -7536
Tgfb1 -7445
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Psmb1 -6399
Psmb6 -6200
Psma2 -6169

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Cbfb -8474
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Psmc6 -7536
Tgfb1 -7445
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Psmb1 -6399
Psmb6 -6200
Psma2 -6169
Psmd10 -5518
Psmd6 -5516
Psme1 -5290
Psmb9 -4797
Ubb -4777
Psmb4 -4713
Psmb8 -4445
Psmd11 -4311
Psmb5 -3923
Psmb10 -3806
Psmd4 -3790
Psmc5 -3637
Psmc1 -3600
Psmc3 -3073
Uba52 -2734
Psma5 -2323
Psmc4 -1980
Smurf2 -1709
Ubc -1368
Psmb7 -1285
Psmd8 -1101
Psmd9 -960
Psmb2 -709
Psmd13 -469
Psmd3 6
Psmd7 94
Ep300 1462
Src 1697
Psme3 2393
Psmf1 2577
Mdm2 4949
Psmd2 6444
Smurf1 7044


RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
839
set RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize 125
pANOVA 8.49e-14
s.dist -0.386
p.adjustANOVA 1e-11



Top enriched genes

Top 20 genes
GeneID Gene Rank
mt-Nd6 -8802
mt-Nd2 -8617
mt-Nd3 -8399
Ndufaf2 -8280
mt-Nd4 -8047
Ndufaf5 -7997
Ndufaf4 -7906
mt-Nd5 -7797
mt-Co3 -7668
mt-Co2 -7592
mt-Nd1 -7586
Ndufa6 -7485
Coq10b -7404
mt-Co1 -7188
Ndufaf6 -7045
Ndufb5 -6979
Tmem186 -6968
Atp5h -6957
Atp5pb -6909
Cox16 -6867

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
mt-Nd6 -8802
mt-Nd2 -8617
mt-Nd3 -8399
Ndufaf2 -8280
mt-Nd4 -8047
Ndufaf5 -7997
Ndufaf4 -7906
mt-Nd5 -7797
mt-Co3 -7668
mt-Co2 -7592
mt-Nd1 -7586
Ndufa6 -7485
Coq10b -7404
mt-Co1 -7188
Ndufaf6 -7045
Ndufb5 -6979
Tmem186 -6968
Atp5h -6957
Atp5pb -6909
Cox16 -6867
mt-Cytb -6802
Ndufv2 -6747
Ndufc1 -6577
Cox11 -6479
mt-Atp6 -6402
Uqcr10 -6314
Acad9 -6205
Uqcrh -6107
Ndufa4 -6059
Ndufb2 -5991
Ndufb8 -5944
Tmem126b -5928
Ndufs5 -5901
Ndufb7 -5832
Ndufaf1 -5819
Cox19 -5623
Ndufb6 -5617
Ndufb1 -5610
Ndufb9 -5554
Atp5l -5513
Ndufb11 -5506
Nubpl -5459
Ndufs4 -5453
Cycs -5431
Cox6c -5366
Ndufb3 -5347
Ndufa7 -5328
Ndufa11 -5284
Timmdc1 -5194
Cox7c -5170
Atp5j2 -5123
Uqcrq -5122
Cox7a2l -5118
Atp5g1 -5117
Atp5o -5087
Slc25a14 -4971
Ndufa2 -4952
Atp5c1 -4943
Cox7b -4937
Sco2 -4847
Ndufb4 -4836
Ndufc2 -4687
Cox5a -4660
Ndufa8 -4285
Uqcrc2 -4226
Atp5j -4220
Ndufs6 -4125
Sdhc -4031
Uqcrb -3805
Atp5e -3789
Cox4i1 -3773
Uqcrc1 -3688
Cox6b1 -3552
Cox18 -3386
Sdhb -3338
Ndufs8 -3266
Ndufb10 -3215
Cox8a -3134
Ndufv3 -3043
Cox5b -2962
Ndufa3 -2882
Ndufa5 -2863
Cyc1 -2440
Etfdh -2320
Ndufa9 -2263
Uqcr11 -2258
Taco1 -2193
Uqcrfs1 -2059
Cox6a1 -1961
Ndufa1 -1801
Sdhd -1687
Etfb -1615
Atp5k -1551
Ndufa10 -1508
Ndufa12 -1388
Ndufs3 -1228
Ecsit -1156
Cox20 -1148
Ndufs7 -1125
mt-Atp8 -995
Coq10a -963
Atp5g3 -955
Ndufv1 -937
Ndufaf7 -936
Etfa -835
Ndufab1 -800
Ndufa13 -554
Pm20d1 -515
Surf1 -326
Atp5b -255
Atp5g2 29
Atp5a1 91
Ndufs2 484
Cox14 759
Sdha 1760
Ndufaf3 2156
Atp5d 2427
Slc25a27 3270
Trap1 3342
Ndufs1 3474
Dmac2l 3489
Lrpprc 5296
Sco1 6559
Ucp2 8275
Ucp3 8522


DEGRADATION OF DVL

DEGRADATION OF DVL
225
set DEGRADATION OF DVL
setSize 55
pANOVA 8.1e-07
s.dist -0.385
p.adjustANOVA 2.97e-05



Top enriched genes

Top 20 genes
GeneID Gene Rank
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Hecw1 -7743
Psmc6 -7536
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Psmb1 -6399
Psmb6 -6200
Psma2 -6169
Psmd10 -5518

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Psma4 -8222
Psma1 -8126
Psmd5 -8116
Psmd12 -7812
Hecw1 -7743
Psmc6 -7536
Psmc2 -7131
Psmd14 -7122
Rps27a -6969
Psmb3 -6924
Psma7 -6871
Psmd1 -6789
Psma3 -6623
Sem1 -6563
Psma6 -6549
Psme2 -6497
Psmb1 -6399
Psmb6 -6200
Psma2 -6169
Psmd10 -5518
Psmd6 -5516
Dact1 -5349
Psme1 -5290
Cul3 -5038
Psmb9 -4797
Ubb -4777
Psmb4 -4713
Psmb8 -4445
Psmd11 -4311
Psmb5 -3923
Psmb10 -3806
Psmd4 -3790
Psmc5 -3637
Psmc1 -3600
Psmc3 -3073
Dvl1 -3071
Uba52 -2734
Psma5 -2323
Psmc4 -1980
Ubc -1368
Psmb7 -1285
Psmd8 -1101
Psmd9 -960
Psmb2 -709
Psmd13 -469
Psmd3 6
Psmd7 94
Rbx1 254
Klhl12 2142
Dvl2 2182
Psme3 2393
Psmf1 2577
Dvl3 2680
Psmd2 6444
Psme4 6731


NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD
634
set NONSENSE MEDIATED DECAY NMD
setSize 109
pANOVA 5.77e-12
s.dist -0.382
p.adjustANOVA 4.26e-10



Top enriched genes

Top 20 genes
GeneID Gene Rank
Magohb -8868
Rbm8a -8725
Rpl11 -7708
Pnrc2 -7691
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Magoh -7335
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Magohb -8868
Rbm8a -8725
Rpl11 -7708
Pnrc2 -7691
Rps23 -7621
Rpl27 -7486
Rpl31 -7476
Rps8 -7336
Magoh -7335
Rpl26 -7286
Rpl24 -7198
Rps25 -7195
Rps12 -7156
Rps24 -6975
Rps27a -6969
Rpl22l1 -6859
Rpl39 -6805
Rpl17 -6723
Rpl19 -6713
Rpl13a -6693
Rps19 -6667
Rps11 -6647
Rps3a1 -6556
Fau -6452
Rpl35 -6281
Rpl36a -6272
Rps7 -6226
Rpl23a -6214
Rps15 -6157
Rps3 -6040
Rpl27a -6018
Rpl36al -6014
Rpl9 -6004
Rpl35a -5975
Rpl34 -5963
Rps27 -5938
Rps10 -5925
Rpl13 -5924
Rpl6 -5898
Rps26 -5809
Rps17 -5738
Rpl21 -5718
Rpl37a -5672
Gspt2 -5653
Upf3b -5630
Rpl7 -5582
Rpsa -5493
Rps9 -5458
Rps27l -5441
Rpl14 -5423
Rpl4 -5373
Rpl23 -5330
Rps18 -5277
Rps20 -5257
Rpl37 -5237
Rps16 -5226
Rpl10a -5182
Rpl32 -5161
Rps21 -4966
Etf1 -4927
Rpl3 -4794
Rpl38 -4676
Rps5 -4675
Rps6 -4661
Pabpc1 -4581
Rpl36 -4525
Rplp0 -4097
Rpl8 -4033
Rps14 -4004
Ppp2r2a -4000
Rplp1 -3988
Rpl18 -3948
Rpl7a -3883
Rps4x -3874
Rpl30 -3803
Upf2 -3777
Rps28 -3120
Rps13 -2924
Uba52 -2734
Rnps1 -2644
Rps2 -2210
Ncbp2 -2209
Ppp2ca -1882
Rplp2 -1540
Rpl12 -1415
Rpl28 -1401
Rpl29 -1236
Rpl18a -1198
Rpl15 -1189
Rps29 -259
Rps15a 399
Ncbp1 509
Eif4a3 1717
Gspt1 1743
Rpl22 2503
Ppp2r1a 2658
Smg7 2856
Eif4g1 3758
Upf1 4027
Smg1 4271
Smg8 5067
Casc3 5442
Rpl5 6278
Smg9 6307
Upf3a 6897
Dcp1a 7048
Smg6 7408
Smg5 8166
Rpl10 8261


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.3                echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.4               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58.1               fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.1        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.4        
## [23] IRanges_2.30.1              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.2               stringr_1.4.1              
## [29] dplyr_1.0.10                purrr_0.3.5                
## [31] readr_2.1.3                 tidyr_1.2.1                
## [33] tibble_3.1.8                ggplot2_3.3.6              
## [35] tidyverse_1.3.2             zoo_1.8-11                 
## 
## loaded via a namespace (and not attached):
##   [1] googledrive_2.0.0      colorspace_2.0-3       ellipsis_0.3.2        
##   [4] XVector_0.36.0         fs_1.5.2               rstudioapi_0.14       
##   [7] bit64_4.0.5            AnnotationDbi_1.58.0   fansi_1.0.3           
##  [10] lubridate_1.8.0        xml2_1.3.3             codetools_0.2-18      
##  [13] splines_4.2.1          cachem_1.0.6           knitr_1.40            
##  [16] geneplotter_1.74.0     jsonlite_1.8.2         broom_1.0.1           
##  [19] annotate_1.74.0        dbplyr_2.2.1           png_0.1-7             
##  [22] shiny_1.7.2            compiler_4.2.1         httr_1.4.4            
##  [25] backports_1.4.1        assertthat_0.2.1       Matrix_1.5-1          
##  [28] fastmap_1.1.0          gargle_1.2.1           cli_3.4.1             
##  [31] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
##  [34] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
##  [37] fastmatch_1.1-3        Rcpp_1.0.9             jquerylib_0.1.4       
##  [40] cellranger_1.1.0       vctrs_0.4.2            Biostrings_2.64.1     
##  [43] svglite_2.1.0          xfun_0.33              rvest_1.0.3           
##  [46] mime_0.12              lifecycle_1.0.3        XML_3.99-0.11         
##  [49] googlesheets4_1.0.1    zlibbioc_1.42.0        scales_1.2.1          
##  [52] hms_1.1.2              promises_1.2.0.1       parallel_4.2.1        
##  [55] RColorBrewer_1.1-3     yaml_2.3.5             memoise_2.0.1         
##  [58] gridExtra_2.3          sass_0.4.2             reshape_0.8.9         
##  [61] stringi_1.7.8          RSQLite_2.2.18         highr_0.9             
##  [64] genefilter_1.78.0      caTools_1.18.2         BiocParallel_1.30.3   
##  [67] systemfonts_1.0.4      rlang_1.0.6            pkgconfig_2.0.3       
##  [70] bitops_1.0-7           evaluate_0.17          lattice_0.20-45       
##  [73] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.2.0      
##  [76] plyr_1.8.7             magrittr_2.0.3         R6_2.5.1              
##  [79] generics_0.1.3         DelayedArray_0.22.0    DBI_1.1.3             
##  [82] pillar_1.8.1           haven_2.5.1            withr_2.5.0           
##  [85] survival_3.4-0         KEGGREST_1.36.3        RCurl_1.98-1.9        
##  [88] modelr_0.1.9           crayon_1.5.2           KernSmooth_2.23-20    
##  [91] utf8_1.2.2             rmarkdown_2.17         tzdb_0.3.0            
##  [94] locfit_1.5-9.6         grid_4.2.1             readxl_1.4.1          
##  [97] data.table_1.14.2      blob_1.2.3             webshot_0.5.4         
## [100] reprex_2.0.2           digest_0.6.29          xtable_1.8-4          
## [103] httpuv_1.6.6           munsell_0.5.0          viridisLite_0.4.1     
## [106] bslib_0.4.0

END of report