date generated: 2022-10-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                         x
## 0610009B22Rik -0.23239644
## 0610009E02Rik -1.02165121
## 0610009L18Rik -0.01240851
## 0610010K14Rik -0.07303716
## 0610012G03Rik  0.88341789
## 0610030E20Rik  0.32408607
Here are some metrics about the input data profile:
Profile metrics
Profile metrics
num_genesets 1604
num_genes_in_profile 16956
duplicated_genes_present 0
num_profile_genes_in_sets 8310
num_profile_genes_not_in_sets 8646

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt
Gene sets metrics
Gene sets metrics
num_genesets 1604
num_genesets_excluded 431
num_genesets_included 1173

Differential pathway expression


Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets
set setSize pANOVA s.dist p.adjustANOVA
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.87e-04 -0.662 0.01510
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 2.64e-04 -0.635 0.01510
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 19 2.49e-06 0.624 0.00122
COMMON PATHWAY OF FIBRIN CLOT FORMATION 10 7.10e-04 0.618 0.02520
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 3.32e-04 0.598 0.01560
BIOTIN TRANSPORT AND METABOLISM 11 1.60e-03 0.549 0.04080
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 8.74e-03 -0.479 0.11200
ATTENUATION PHASE 24 8.72e-05 -0.463 0.00731
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 4.25e-03 -0.458 0.07450
PURINE CATABOLISM 16 1.69e-03 0.453 0.04160
P38MAPK EVENTS 12 6.81e-03 -0.451 0.09400
TRAF6 MEDIATED IRF7 ACTIVATION 15 2.62e-03 -0.449 0.05430
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 4.39e-03 -0.440 0.07460
ERYTHROPOIETIN ACTIVATES RAS 13 6.39e-03 -0.437 0.08920
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.19e-03 -0.429 0.04840
SIGNALING BY FGFR4 IN DISEASE 10 1.88e-02 -0.429 0.16900
MET ACTIVATES RAP1 AND RAC1 11 1.39e-02 -0.428 0.14700
MUCOPOLYSACCHARIDOSES 11 1.42e-02 0.427 0.14800
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.00e-02 -0.405 0.17700
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.53e-02 -0.404 0.15500
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.34e-03 -0.402 0.08340
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.21e-02 -0.402 0.13600
HSF1 ACTIVATION 26 5.44e-04 -0.392 0.02270
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 1.02e-04 0.391 0.00753
SIGNALING BY ERYTHROPOIETIN 24 1.03e-03 -0.387 0.03170
PKA MEDIATED PHOSPHORYLATION OF CREB 19 3.53e-03 -0.387 0.06460
RHOBTB2 GTPASE CYCLE 23 1.37e-03 -0.386 0.03660
MET ACTIVATES RAS SIGNALING 10 3.69e-02 -0.381 0.24400
INTERLEUKIN 27 SIGNALING 10 4.16e-02 -0.372 0.25400
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.30e-02 -0.370 0.25900
CONSTITUTIVE SIGNALING BY EGFRVIII 15 1.34e-02 -0.369 0.14300
INTERLEUKIN 35 SIGNALLING 10 4.91e-02 -0.359 0.26400
EPHRIN SIGNALING 19 6.92e-03 -0.358 0.09440
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 5.24e-02 0.354 0.27300
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.51e-03 -0.350 0.08340
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 9.54e-04 -0.349 0.03050
ANTIMICROBIAL PEPTIDES 15 2.19e-02 0.342 0.18400
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 6.19e-02 -0.341 0.29800
PLASMA LIPOPROTEIN ASSEMBLY 11 5.17e-02 0.339 0.27100
GP1B IX V ACTIVATION SIGNALLING 10 6.52e-02 0.337 0.30700
NUCLEOBASE CATABOLISM 31 1.19e-03 0.336 0.03390
INSULIN PROCESSING 24 4.39e-03 -0.336 0.07460
SIGNALING BY KIT IN DISEASE 20 9.73e-03 -0.334 0.11600
PLATELET ADHESION TO EXPOSED COLLAGEN 11 5.66e-02 0.332 0.28500
ASPARTATE AND ASPARAGINE METABOLISM 11 5.68e-02 0.332 0.28500
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.72e-02 -0.331 0.26400
REGULATION OF IFNA SIGNALING 12 4.85e-02 -0.329 0.26400
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.32e-02 -0.328 0.14300
CD209 DC SIGN SIGNALING 18 1.60e-02 -0.328 0.15800
BRANCHED CHAIN AMINO ACID CATABOLISM 21 9.75e-03 0.326 0.11600


Results (complete table)


Click HERE to show results for all gene sets

Complete results
set setSize pANOVA s.dist p.adjustANOVA
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES 10 2.87e-04 -0.662000 0.01510
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K 11 2.64e-04 -0.635000 0.01510
FORMATION OF FIBRIN CLOT CLOTTING CASCADE 19 2.49e-06 0.624000 0.00122
COMMON PATHWAY OF FIBRIN CLOT FORMATION 10 7.10e-04 0.618000 0.02520
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION 12 3.32e-04 0.598000 0.01560
BIOTIN TRANSPORT AND METABOLISM 11 1.60e-03 0.549000 0.04080
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS 10 8.74e-03 -0.479000 0.11200
ATTENUATION PHASE 24 8.72e-05 -0.463000 0.00731
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME 13 4.25e-03 -0.458000 0.07450
PURINE CATABOLISM 16 1.69e-03 0.453000 0.04160
P38MAPK EVENTS 12 6.81e-03 -0.451000 0.09400
TRAF6 MEDIATED IRF7 ACTIVATION 15 2.62e-03 -0.449000 0.05430
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 14 4.39e-03 -0.440000 0.07460
ERYTHROPOIETIN ACTIVATES RAS 13 6.39e-03 -0.437000 0.08920
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY 17 2.19e-03 -0.429000 0.04840
SIGNALING BY FGFR4 IN DISEASE 10 1.88e-02 -0.429000 0.16900
MET ACTIVATES RAP1 AND RAC1 11 1.39e-02 -0.428000 0.14700
MUCOPOLYSACCHARIDOSES 11 1.42e-02 0.427000 0.14800
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE 11 2.00e-02 -0.405000 0.17700
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES 12 1.53e-02 -0.404000 0.15500
SEMA3A PAK DEPENDENT AXON REPULSION 16 5.34e-03 -0.402000 0.08340
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 13 1.21e-02 -0.402000 0.13600
HSF1 ACTIVATION 26 5.44e-04 -0.392000 0.02270
MITOCHONDRIAL FATTY ACID BETA OXIDATION 33 1.02e-04 0.391000 0.00753
SIGNALING BY ERYTHROPOIETIN 24 1.03e-03 -0.387000 0.03170
PKA MEDIATED PHOSPHORYLATION OF CREB 19 3.53e-03 -0.387000 0.06460
RHOBTB2 GTPASE CYCLE 23 1.37e-03 -0.386000 0.03660
MET ACTIVATES RAS SIGNALING 10 3.69e-02 -0.381000 0.24400
INTERLEUKIN 27 SIGNALING 10 4.16e-02 -0.372000 0.25400
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS 10 4.30e-02 -0.370000 0.25900
CONSTITUTIVE SIGNALING BY EGFRVIII 15 1.34e-02 -0.369000 0.14300
INTERLEUKIN 35 SIGNALLING 10 4.91e-02 -0.359000 0.26400
EPHRIN SIGNALING 19 6.92e-03 -0.358000 0.09440
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS 10 5.24e-02 0.354000 0.27300
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION 21 5.51e-03 -0.350000 0.08340
REGULATION OF MECP2 EXPRESSION AND ACTIVITY 30 9.54e-04 -0.349000 0.03050
ANTIMICROBIAL PEPTIDES 15 2.19e-02 0.342000 0.18400
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS 10 6.19e-02 -0.341000 0.29800
PLASMA LIPOPROTEIN ASSEMBLY 11 5.17e-02 0.339000 0.27100
GP1B IX V ACTIVATION SIGNALLING 10 6.52e-02 0.337000 0.30700
NUCLEOBASE CATABOLISM 31 1.19e-03 0.336000 0.03390
INSULIN PROCESSING 24 4.39e-03 -0.336000 0.07460
SIGNALING BY KIT IN DISEASE 20 9.73e-03 -0.334000 0.11600
PLATELET ADHESION TO EXPOSED COLLAGEN 11 5.66e-02 0.332000 0.28500
ASPARTATE AND ASPARAGINE METABOLISM 11 5.68e-02 0.332000 0.28500
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 4.72e-02 -0.331000 0.26400
REGULATION OF IFNA SIGNALING 12 4.85e-02 -0.329000 0.26400
VEGFR2 MEDIATED CELL PROLIFERATION 19 1.32e-02 -0.328000 0.14300
CD209 DC SIGN SIGNALING 18 1.60e-02 -0.328000 0.15800
BRANCHED CHAIN AMINO ACID CATABOLISM 21 9.75e-03 0.326000 0.11600
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING 35 8.70e-04 -0.325000 0.02920
HSF1 DEPENDENT TRANSACTIVATION 34 1.21e-03 -0.321000 0.03390
REGULATION OF SIGNALING BY CBL 22 9.81e-03 -0.318000 0.11600
CHEMOKINE RECEPTORS BIND CHEMOKINES 13 4.76e-02 -0.317000 0.26400
LYSINE CATABOLISM 11 7.11e-02 0.314000 0.31800
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP 43 3.84e-04 -0.313000 0.01670
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL 13 5.14e-02 0.312000 0.27000
GAP JUNCTION ASSEMBLY 20 1.61e-02 0.311000 0.15800
PROCESSING OF SMDT1 16 3.29e-02 0.308000 0.22700
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION 14 4.63e-02 0.308000 0.26400
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 23 1.08e-02 -0.307000 0.12600
RAF INDEPENDENT MAPK1 3 ACTIVATION 20 1.78e-02 -0.306000 0.16400
SIGNALING BY ERBB2 ECD MUTANTS 16 3.45e-02 -0.305000 0.23400
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY 13 5.86e-02 -0.303000 0.29100
REGULATION OF BACH1 ACTIVITY 11 8.28e-02 0.302000 0.33700
PYRIMIDINE CATABOLISM 10 9.82e-02 0.302000 0.35800
FCERI MEDIATED MAPK ACTIVATION 28 6.04e-03 -0.300000 0.08850
INTERFERON ALPHA BETA SIGNALING 53 1.66e-04 -0.299000 0.01150
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 16 3.92e-02 -0.298000 0.24900
DERMATAN SULFATE BIOSYNTHESIS 11 8.77e-02 0.297000 0.34100
APOPTOSIS INDUCED DNA FRAGMENTATION 11 8.86e-02 0.297000 0.34100
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 10 1.05e-01 -0.296000 0.36700
EPHB MEDIATED FORWARD SIGNALING 42 9.64e-04 -0.294000 0.03050
SIGNALING BY FGFR3 FUSIONS IN CANCER 10 1.07e-01 -0.294000 0.36700
SIGNALLING TO RAS 18 3.18e-02 -0.292000 0.22400
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN 37 2.15e-03 -0.292000 0.04840
ONCOGENIC MAPK SIGNALING 76 1.17e-05 -0.291000 0.00216
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES 14 6.01e-02 -0.290000 0.29600
LONG TERM POTENTIATION 23 1.63e-02 -0.290000 0.15800
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2 13 7.10e-02 0.289000 0.31800
RHOBTB GTPASE CYCLE 35 3.27e-03 -0.287000 0.06190
CALNEXIN CALRETICULIN CYCLE 26 1.14e-02 -0.287000 0.13000
RORA ACTIVATES GENE EXPRESSION 18 3.55e-02 -0.286000 0.23900
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2 11 1.02e-01 -0.285000 0.36500
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM 12 8.85e-02 0.284000 0.34100
MET RECEPTOR RECYCLING 10 1.20e-01 -0.284000 0.39200
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 12 9.00e-02 0.283000 0.34300
PKMTS METHYLATE HISTONE LYSINES 49 6.35e-04 -0.282000 0.02400
TIGHT JUNCTION INTERACTIONS 18 3.83e-02 0.282000 0.24900
CRMPS IN SEMA3A SIGNALING 16 5.14e-02 -0.281000 0.27000
NEUREXINS AND NEUROLIGINS 54 3.75e-04 -0.280000 0.01670
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES 20 3.08e-02 -0.279000 0.22000
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION 21 2.74e-02 -0.278000 0.20800
GLUTATHIONE CONJUGATION 29 9.57e-03 0.278000 0.11600
RNA POLYMERASE III CHAIN ELONGATION 18 4.13e-02 0.278000 0.25400
SUMOYLATION OF DNA METHYLATION PROTEINS 16 5.50e-02 -0.277000 0.28000
KERATAN SULFATE DEGRADATION 11 1.16e-01 0.274000 0.38500
DSCAM INTERACTIONS 10 1.35e-01 -0.273000 0.41800
METHYLATION 12 1.02e-01 0.272000 0.36600
IRE1ALPHA ACTIVATES CHAPERONES 49 1.08e-03 -0.270000 0.03180
CA DEPENDENT EVENTS 36 5.17e-03 -0.269000 0.08340
OVARIAN TUMOR DOMAIN PROTEASES 36 5.20e-03 -0.269000 0.08340
TRANSLESION SYNTHESIS BY POLK 17 5.53e-02 0.269000 0.28100
DISSOLUTION OF FIBRIN CLOT 10 1.46e-01 0.266000 0.43100
DAG AND IP3 SIGNALING 40 3.76e-03 -0.265000 0.06780
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS 12 1.13e-01 -0.264000 0.38000
INTERLEUKIN 6 SIGNALING 10 1.49e-01 -0.264000 0.43200
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING 20 4.20e-02 -0.263000 0.25500
TYPE I HEMIDESMOSOME ASSEMBLY 10 1.51e-01 -0.262000 0.43300
ADENYLATE CYCLASE ACTIVATING PATHWAY 10 1.52e-01 -0.262000 0.43400
PEROXISOMAL LIPID METABOLISM 26 2.10e-02 0.262000 0.18400
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION 25 2.39e-02 0.261000 0.19700
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS 54 1.07e-03 -0.257000 0.03180
HEME SIGNALING 45 2.83e-03 -0.257000 0.05640
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR 20 4.65e-02 -0.257000 0.26400
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS 12 1.24e-01 -0.257000 0.40200
CAMK IV MEDIATED PHOSPHORYLATION OF CREB 10 1.61e-01 -0.256000 0.44400
NS1 MEDIATED EFFECTS ON HOST PATHWAYS 37 7.08e-03 -0.256000 0.09550
PKA ACTIVATION IN GLUCAGON SIGNALLING 16 7.66e-02 -0.256000 0.32700
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 19 5.40e-02 0.255000 0.27800
COHESIN LOADING ONTO CHROMATIN 10 1.63e-01 -0.255000 0.44400
ACTIVATION OF SMO 16 7.84e-02 -0.254000 0.33000
MITOCHONDRIAL TRANSLATION 93 2.29e-05 0.254000 0.00244
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 22 4.10e-02 -0.252000 0.25400
SIGNAL AMPLIFICATION 30 1.80e-02 -0.250000 0.16400
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1 23 3.93e-02 -0.248000 0.24900
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS 18 7.02e-02 -0.246000 0.31800
PHASE II CONJUGATION OF COMPOUNDS 62 7.98e-04 0.246000 0.02750
SIGNALING BY PDGFR IN DISEASE 20 5.69e-02 -0.246000 0.28500
RUNX2 REGULATES BONE DEVELOPMENT 29 2.20e-02 -0.246000 0.18400
VXPX CARGO TARGETING TO CILIUM 19 6.51e-02 -0.244000 0.30700
INTERACTION BETWEEN L1 AND ANKYRINS 27 2.82e-02 -0.244000 0.21100
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS 17 8.17e-02 -0.244000 0.33600
DAP12 INTERACTIONS 28 2.55e-02 -0.244000 0.20500
FERTILIZATION 10 1.82e-01 -0.244000 0.47200
INTERLEUKIN 10 SIGNALING 20 6.06e-02 -0.242000 0.29600
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION 10 1.85e-01 -0.242000 0.47300
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS 19 6.79e-02 -0.242000 0.31400
UNWINDING OF DNA 12 1.48e-01 0.241000 0.43100
VEGFR2 MEDIATED VASCULAR PERMEABILITY 27 3.01e-02 -0.241000 0.21600
ANCHORING FIBRIL FORMATION 15 1.07e-01 -0.241000 0.36700
PENTOSE PHOSPHATE PATHWAY 13 1.33e-01 0.241000 0.41800
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS 41 7.84e-03 -0.240000 0.10200
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION 31 2.12e-02 0.239000 0.18400
SIGNALING BY RETINOIC ACID 33 1.75e-02 0.239000 0.16300
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 31 2.14e-02 -0.239000 0.18400
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS 11 1.71e-01 -0.238000 0.46200
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION 26 3.58e-02 -0.238000 0.24000
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX 15 1.11e-01 0.238000 0.37800
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING 28 2.97e-02 -0.237000 0.21500
CELLULAR HEXOSE TRANSPORT 11 1.75e-01 0.236000 0.46500
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS 31 2.31e-02 -0.236000 0.19200
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES 85 1.82e-04 -0.235000 0.01190
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE 13 1.43e-01 0.235000 0.43000
ERKS ARE INACTIVATED 13 1.43e-01 -0.235000 0.43000
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN 20 7.07e-02 -0.233000 0.31800
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING 11 1.81e-01 -0.233000 0.47200
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 17 9.67e-02 -0.233000 0.35500
SIGNALING BY BRAF AND RAF FUSIONS 60 1.85e-03 -0.232000 0.04330
ERK MAPK TARGETS 22 6.16e-02 -0.230000 0.29800
BIOLOGICAL OXIDATIONS 123 1.06e-05 0.230000 0.00216
INTERLEUKIN RECEPTOR SHC SIGNALING 20 7.54e-02 -0.230000 0.32500
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF 56 2.96e-03 -0.230000 0.05790
COMPLEMENT CASCADE 30 2.95e-02 0.230000 0.21500
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 23 5.73e-02 -0.229000 0.28600
OTHER SEMAPHORIN INTERACTIONS 19 8.44e-02 -0.229000 0.33900
ELASTIC FIBRE FORMATION 37 1.61e-02 0.229000 0.15800
G PROTEIN ACTIVATION 22 6.44e-02 -0.228000 0.30600
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS 87 2.45e-04 0.228000 0.01510
UNFOLDED PROTEIN RESPONSE UPR 85 2.91e-04 -0.227000 0.01510
INTERFERON GAMMA SIGNALING 75 6.88e-04 -0.227000 0.02520
PERK REGULATES GENE EXPRESSION 28 3.91e-02 -0.225000 0.24900
ACETYLCHOLINE REGULATES INSULIN SECRETION 10 2.17e-01 -0.225000 0.52000
EARLY PHASE OF HIV LIFE CYCLE 13 1.61e-01 0.224000 0.44400
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 22 6.86e-02 -0.224000 0.31400
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER 28 4.00e-02 0.224000 0.25200
G PROTEIN MEDIATED EVENTS 52 5.26e-03 -0.224000 0.08340
ADENYLATE CYCLASE INHIBITORY PATHWAY 13 1.65e-01 -0.222000 0.44800
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS 12 1.86e-01 -0.221000 0.47400
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE 35 2.42e-02 -0.220000 0.19700
INTEGRIN SIGNALING 24 6.20e-02 -0.220000 0.29800
RAF ACTIVATION 34 2.65e-02 -0.220000 0.20600
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING 34 2.65e-02 -0.220000 0.20600
CIRCADIAN CLOCK 68 1.72e-03 -0.220000 0.04160
TRANSCRIPTIONAL REGULATION BY E2F6 34 2.67e-02 -0.220000 0.20600
REGULATION OF TP53 EXPRESSION AND DEGRADATION 35 2.48e-02 -0.219000 0.20100
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS 13 1.72e-01 0.219000 0.46200
SIGNALLING TO ERKS 32 3.25e-02 -0.218000 0.22600
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS 13 1.74e-01 -0.218000 0.46300
GENERATION OF SECOND MESSENGER MOLECULES 17 1.20e-01 0.218000 0.39200
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS 83 6.05e-04 -0.218000 0.02360
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION 14 1.60e-01 -0.217000 0.44400
CHOLESTEROL BIOSYNTHESIS 24 6.57e-02 -0.217000 0.30700
FCGR3A MEDIATED IL10 SYNTHESIS 34 2.88e-02 -0.217000 0.21300
FATTY ACID METABOLISM 144 7.62e-06 0.216000 0.00216
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC 19 1.03e-01 -0.216000 0.36600
SIGNALING BY ERBB2 IN CANCER 24 6.74e-02 -0.216000 0.31300
MOLECULES ASSOCIATED WITH ELASTIC FIBRES 31 3.78e-02 0.216000 0.24800
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 23 7.36e-02 -0.215000 0.32300
RHOBTB1 GTPASE CYCLE 23 7.44e-02 -0.215000 0.32300
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA 63 3.26e-03 -0.214000 0.06190
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS 18 1.16e-01 -0.214000 0.38500
FORMATION OF THE CORNIFIED ENVELOPE 31 3.93e-02 0.214000 0.24900
KERATINIZATION 31 3.93e-02 0.214000 0.24900
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS 26 6.00e-02 -0.213000 0.29600
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA 13 1.85e-01 -0.212000 0.47300
INTERFERON SIGNALING 163 3.11e-06 -0.212000 0.00122
TRANSCRIPTIONAL REGULATION BY MECP2 60 4.58e-03 -0.212000 0.07680
MTORC1 MEDIATED SIGNALLING 24 7.27e-02 0.212000 0.32200
NCAM SIGNALING FOR NEURITE OUT GROWTH 58 5.55e-03 -0.211000 0.08340
GAP JUNCTION TRAFFICKING AND REGULATION 32 4.14e-02 0.208000 0.25400
MEIOTIC RECOMBINATION 38 2.63e-02 0.208000 0.20600
P75NTR REGULATES AXONOGENESIS 10 2.54e-01 0.208000 0.55900
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI 18 1.26e-01 -0.208000 0.40700
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE 76 1.74e-03 -0.208000 0.04160
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS 58 6.23e-03 -0.208000 0.08920
DAP12 SIGNALING 24 7.85e-02 -0.207000 0.33000
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL 12 2.15e-01 0.207000 0.51800
CELLULAR RESPONSE TO HEAT STRESS 95 5.60e-04 -0.205000 0.02270
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3 10 2.62e-01 -0.205000 0.57000
RHOV GTPASE CYCLE 32 4.54e-02 -0.204000 0.26400
SIGNALING BY FGFR1 IN DISEASE 32 4.64e-02 -0.204000 0.26400
DETOXIFICATION OF REACTIVE OXYGEN SPECIES 31 5.01e-02 0.203000 0.26700
CTLA4 INHIBITORY SIGNALING 20 1.16e-01 -0.203000 0.38500
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1 24 8.63e-02 -0.202000 0.34100
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 74 2.64e-03 -0.202000 0.05430
NCAM1 INTERACTIONS 38 3.11e-02 -0.202000 0.22100
FORMATION OF INCISION COMPLEX IN GG NER 43 2.20e-02 0.202000 0.18400
MITOTIC TELOPHASE CYTOKINESIS 13 2.08e-01 -0.202000 0.51000
INTERLEUKIN 20 FAMILY SIGNALING 13 2.10e-01 -0.201000 0.51400
NEGATIVE REGULATION OF MAPK PATHWAY 41 2.65e-02 -0.200000 0.20600
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION 26 7.75e-02 -0.200000 0.32800
INTERLEUKIN 2 FAMILY SIGNALING 33 4.79e-02 -0.199000 0.26400
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER 26 7.90e-02 -0.199000 0.33100
SIGNALING BY FLT3 FUSION PROTEINS 18 1.45e-01 -0.198000 0.43100
CITRIC ACID CYCLE TCA CYCLE 22 1.08e-01 0.198000 0.36700
SEMAPHORIN INTERACTIONS 64 6.25e-03 -0.198000 0.08920
MATURATION OF NUCLEOPROTEIN 10 2.79e-01 -0.198000 0.58400
SIGNALING BY BMP 25 8.73e-02 -0.198000 0.34100
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION 23 1.01e-01 -0.197000 0.36400
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 12 2.37e-01 0.197000 0.53800
SIGNALING BY FGFR1 42 2.81e-02 -0.196000 0.21100
DOWNSTREAM SIGNAL TRANSDUCTION 29 6.84e-02 -0.196000 0.31400
NOD1 2 SIGNALING PATHWAY 34 4.86e-02 -0.195000 0.26400
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS 10 2.86e-01 -0.195000 0.58700
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS 10 2.86e-01 -0.195000 0.58700
FORMATION OF APOPTOSOME 10 2.88e-01 -0.194000 0.58700
CHONDROITIN SULFATE BIOSYNTHESIS 19 1.43e-01 0.194000 0.43000
UPTAKE AND ACTIONS OF BACTERIAL TOXINS 29 7.15e-02 -0.193000 0.31800
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3 22 1.16e-01 0.193000 0.38500
NUCLEOTIDE SALVAGE 21 1.27e-01 0.192000 0.40800
RA BIOSYNTHESIS PATHWAY 13 2.30e-01 0.192000 0.52900
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING 41 3.32e-02 -0.192000 0.22800
TRAF6 MEDIATED NF KB ACTIVATION 21 1.28e-01 -0.192000 0.41000
PURINE SALVAGE 12 2.50e-01 0.192000 0.55300
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS 26 9.18e-02 0.191000 0.34400
OTHER INTERLEUKIN SIGNALING 19 1.50e-01 -0.191000 0.43300
MITOCHONDRIAL CALCIUM ION TRANSPORT 23 1.13e-01 0.191000 0.38000
NUCLEAR IMPORT OF REV PROTEIN 32 6.19e-02 -0.191000 0.29800
APC CDC20 MEDIATED DEGRADATION OF NEK2A 26 9.24e-02 0.191000 0.34500
SUMOYLATION OF UBIQUITINYLATION PROTEINS 37 4.51e-02 -0.190000 0.26400
ACTIVATION OF MATRIX METALLOPROTEINASES 14 2.18e-01 0.190000 0.52000
SIGNALING BY NTRK3 TRKC 17 1.77e-01 -0.189000 0.46700
ER QUALITY CONTROL COMPARTMENT ERQC 21 1.34e-01 -0.189000 0.41800
EXTRA NUCLEAR ESTROGEN SIGNALING 65 8.76e-03 -0.188000 0.11200
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 27 9.14e-02 -0.188000 0.34400
SYNTHESIS OF PE 13 2.42e-01 -0.188000 0.54100
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS 20 1.47e-01 0.187000 0.43100
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 28 8.62e-02 -0.187000 0.34100
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 59 1.28e-02 -0.187000 0.14100
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 51 2.10e-02 0.187000 0.18400
MISCELLANEOUS TRANSPORT AND BINDING EVENTS 20 1.48e-01 -0.187000 0.43100
NEUROTOXICITY OF CLOSTRIDIUM TOXINS 10 3.07e-01 -0.187000 0.60300
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 17 1.83e-01 -0.186000 0.47300
PHASE I FUNCTIONALIZATION OF COMPOUNDS 58 1.41e-02 0.186000 0.14800
DNA DAMAGE RECOGNITION IN GG NER 38 4.72e-02 0.186000 0.26400
GAP JUNCTION DEGRADATION 11 2.86e-01 0.186000 0.58700
INITIAL TRIGGERING OF COMPLEMENT 14 2.31e-01 0.185000 0.52900
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 11 2.89e-01 0.185000 0.58700
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2 23 1.25e-01 -0.185000 0.40500
DNA STRAND ELONGATION 32 7.10e-02 0.184000 0.31800
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR 48 2.72e-02 -0.184000 0.20800
GABA B RECEPTOR ACTIVATION 39 4.69e-02 -0.184000 0.26400
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT 20 1.59e-01 0.182000 0.44400
PHASE 2 PLATEAU PHASE 13 2.59e-01 0.181000 0.56600
CD28 CO STIMULATION 31 8.16e-02 -0.181000 0.33600
PLATELET SENSITIZATION BY LDL 15 2.28e-01 -0.180000 0.52800
SIGNALING BY NTRK2 TRKB 24 1.29e-01 -0.179000 0.41100
PI 3K CASCADE FGFR2 16 2.15e-01 -0.179000 0.51800
MAP2K AND MAPK ACTIVATION 36 6.43e-02 -0.178000 0.30600
SIGNALING BY SCF KIT 41 4.86e-02 -0.178000 0.26400
PROLONGED ERK ACTIVATION EVENTS 13 2.68e-01 -0.177000 0.57800
POLYMERASE SWITCHING 14 2.51e-01 0.177000 0.55300
NUCLEAR PORE COMPLEX NPC DISASSEMBLY 31 8.85e-02 -0.177000 0.34100
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES 16 2.21e-01 -0.177000 0.52200
MEIOSIS 64 1.50e-02 0.176000 0.15300
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12 19 1.84e-01 -0.176000 0.47300
REGULATION OF KIT SIGNALING 16 2.24e-01 -0.176000 0.52400
RETROGRADE NEUROTROPHIN SIGNALLING 13 2.73e-01 0.175000 0.58100
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE 20 1.74e-01 0.175000 0.46400
FORMATION OF THE EARLY ELONGATION COMPLEX 33 8.13e-02 0.175000 0.33600
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX 13 2.76e-01 0.175000 0.58300
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS 35 7.43e-02 -0.174000 0.32300
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS 18 2.00e-01 0.174000 0.49900
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL 10 3.41e-01 0.174000 0.63700
MITOCHONDRIAL PROTEIN IMPORT 63 1.71e-02 0.174000 0.16300
SMOOTH MUSCLE CONTRACTION 32 8.90e-02 0.174000 0.34100
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 18 2.03e-01 -0.173000 0.50200
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS 35 7.63e-02 -0.173000 0.32700
IRF3 MEDIATED INDUCTION OF TYPE I IFN 11 3.21e-01 -0.173000 0.61800
GLUCAGON SIGNALING IN METABOLIC REGULATION 29 1.07e-01 -0.173000 0.36700
SIALIC ACID METABOLISM 32 9.17e-02 0.172000 0.34400
SIGNALING BY EGFR IN CANCER 21 1.72e-01 -0.172000 0.46200
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B 22 1.63e-01 0.172000 0.44400
INTRAFLAGELLAR TRANSPORT 50 3.63e-02 0.171000 0.24200
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 23 1.56e-01 -0.171000 0.44000
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES 11 3.29e-01 -0.170000 0.62800
DISEASES OF CARBOHYDRATE METABOLISM 29 1.14e-01 0.170000 0.38100
SUMOYLATION OF RNA BINDING PROTEINS 45 4.89e-02 -0.170000 0.26400
MITOCHONDRIAL BIOGENESIS 92 4.95e-03 -0.170000 0.08180
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 23 1.61e-01 -0.169000 0.44400
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS 18 2.15e-01 -0.169000 0.51800
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE 18 2.16e-01 -0.169000 0.51800
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN 35 8.56e-02 0.168000 0.34100
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR 21 1.83e-01 0.168000 0.47300
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS 10 3.59e-01 0.167000 0.65500
KERATAN SULFATE BIOSYNTHESIS 25 1.47e-01 0.167000 0.43100
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA 34 9.11e-02 -0.167000 0.34400
EFFECTS OF PIP2 HYDROLYSIS 27 1.33e-01 -0.167000 0.41800
REGULATION OF TNFR1 SIGNALING 34 9.26e-02 -0.167000 0.34500
GLYCOSAMINOGLYCAN METABOLISM 115 2.03e-03 0.167000 0.04680
ONCOGENE INDUCED SENESCENCE 32 1.05e-01 -0.166000 0.36700
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES 32 1.07e-01 0.165000 0.36700
PROTEIN METHYLATION 17 2.40e-01 0.164000 0.53900
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 22 1.82e-01 -0.164000 0.47200
G PROTEIN BETA GAMMA SIGNALLING 30 1.20e-01 -0.164000 0.39200
SIGNALING BY VEGF 102 4.19e-03 -0.164000 0.07440
HYALURONAN METABOLISM 15 2.72e-01 0.164000 0.57900
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7 12 3.26e-01 -0.164000 0.62300
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS 11 3.47e-01 0.164000 0.64300
NUCLEOTIDE LIKE PURINERGIC RECEPTORS 13 3.08e-01 -0.163000 0.60300
GABA RECEPTOR ACTIVATION 53 4.02e-02 -0.163000 0.25200
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 52 4.23e-02 -0.163000 0.25600
GAB1 SIGNALOSOME 13 3.10e-01 -0.163000 0.60300
HYALURONAN UPTAKE AND DEGRADATION 11 3.51e-01 0.163000 0.64800
PYRUVATE METABOLISM 27 1.44e-01 0.162000 0.43100
CHROMATIN MODIFYING ENZYMES 219 3.57e-05 -0.162000 0.00349
NGF STIMULATED TRANSCRIPTION 37 8.80e-02 -0.162000 0.34100
DEFECTS IN VITAMIN AND COFACTOR METABOLISM 21 2.01e-01 0.161000 0.49900
SIGNALING BY ACTIVIN 12 3.34e-01 -0.161000 0.63100
SIGNALING BY ERBB2 48 5.36e-02 -0.161000 0.27800
METABOLISM OF NUCLEOTIDES 92 7.68e-03 0.161000 0.10100
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM 39 8.23e-02 0.161000 0.33700
RNA POLYMERASE II TRANSCRIBES SNRNA GENES 74 1.75e-02 -0.160000 0.16300
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION 30 1.31e-01 -0.159000 0.41300
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS 45 6.54e-02 0.159000 0.30700
SIGNALING BY NOTCH1 75 1.76e-02 -0.159000 0.16300
TRANSLESION SYNTHESIS BY POLH 19 2.31e-01 0.159000 0.52900
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES 15 2.89e-01 -0.158000 0.58800
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS 14 3.06e-01 -0.158000 0.60300
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL 14 3.07e-01 -0.158000 0.60300
MATURATION OF SARS COV 2 SPIKE PROTEIN 29 1.42e-01 -0.158000 0.43000
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 43 7.40e-02 -0.158000 0.32300
PEXOPHAGY 11 3.67e-01 0.157000 0.65800
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER 15 2.92e-01 -0.157000 0.58900
IRS MEDIATED SIGNALLING 38 9.48e-02 -0.157000 0.35000
FCERI MEDIATED CA 2 MOBILIZATION 25 1.76e-01 -0.156000 0.46500
OPIOID SIGNALLING 86 1.22e-02 -0.156000 0.13600
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION 179 3.12e-04 -0.156000 0.01520
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT 23 1.95e-01 0.156000 0.49000
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 63 3.25e-02 0.156000 0.22600
FANCONI ANEMIA PATHWAY 36 1.06e-01 0.156000 0.36700
FREE FATTY ACIDS REGULATE INSULIN SECRETION 10 3.95e-01 -0.155000 0.67900
METABOLISM OF AMINO ACIDS AND DERIVATIVES 316 2.39e-06 0.155000 0.00122
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF 15 3.01e-01 0.154000 0.60100
NICOTINAMIDE SALVAGING 16 2.86e-01 0.154000 0.58700
PI METABOLISM 80 1.74e-02 -0.154000 0.16300
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN 30 1.45e-01 -0.154000 0.43100
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX 41 8.96e-02 -0.153000 0.34200
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR 11 3.79e-01 0.153000 0.67000
INWARDLY RECTIFYING K CHANNELS 31 1.40e-01 -0.153000 0.43000
TNF SIGNALING 43 8.25e-02 -0.153000 0.33700
RHOQ GTPASE CYCLE 58 4.40e-02 -0.153000 0.26300
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM 49 6.41e-02 0.153000 0.30600
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2 11 3.82e-01 -0.152000 0.67300
SUMOYLATION OF SUMOYLATION PROTEINS 33 1.31e-01 -0.152000 0.41300
NOTCH HLH TRANSCRIPTION PATHWAY 28 1.64e-01 -0.152000 0.44600
MAPK FAMILY SIGNALING CASCADES 282 1.29e-05 -0.151000 0.00216
RHO GTPASES ACTIVATE KTN1 11 3.86e-01 0.151000 0.67600
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 21 2.31e-01 0.151000 0.52900
G BETA GAMMA SIGNALLING THROUGH CDC42 18 2.68e-01 -0.151000 0.57800
LAGGING STRAND SYNTHESIS 20 2.46e-01 0.150000 0.54800
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON 17 2.87e-01 -0.149000 0.58700
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY 29 1.65e-01 -0.149000 0.44800
TIE2 SIGNALING 17 2.89e-01 -0.149000 0.58700
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER 84 1.89e-02 0.148000 0.16900
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES 37 1.19e-01 0.148000 0.39200
UPTAKE AND FUNCTION OF ANTHRAX TOXINS 11 3.98e-01 -0.147000 0.68000
MEIOTIC SYNAPSIS 41 1.03e-01 0.147000 0.36600
HIV TRANSCRIPTION ELONGATION 42 9.94e-02 0.147000 0.35900
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE 12 3.79e-01 -0.147000 0.67000
HEPARAN SULFATE HEPARIN HS GAG METABOLISM 52 6.74e-02 0.147000 0.31300
KERATAN SULFATE KERATIN METABOLISM 31 1.60e-01 0.146000 0.44400
SUMOYLATION OF TRANSCRIPTION COFACTORS 42 1.03e-01 -0.145000 0.36600
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT 18 2.87e-01 -0.145000 0.58700
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS 20 2.62e-01 0.145000 0.57000
RHOU GTPASE CYCLE 33 1.50e-01 -0.145000 0.43300
CONDENSATION OF PROPHASE CHROMOSOMES 28 1.85e-01 0.145000 0.47300
RNA POLYMERASE I PROMOTER ESCAPE 48 8.31e-02 0.145000 0.33700
GLUTATHIONE SYNTHESIS AND RECYCLING 11 4.07e-01 0.144000 0.68900
SELENOAMINO ACID METABOLISM 110 9.08e-03 0.144000 0.11200
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 48 8.44e-02 -0.144000 0.33900
SUMOYLATION OF DNA REPLICATION PROTEINS 43 1.03e-01 -0.144000 0.36600
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY 25 2.14e-01 0.144000 0.51800
MICRORNA MIRNA BIOGENESIS 24 2.24e-01 -0.143000 0.52400
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS 19 2.80e-01 -0.143000 0.58400
INOSITOL PHOSPHATE METABOLISM 47 9.04e-02 0.143000 0.34300
CYTOSOLIC SULFONATION OF SMALL MOLECULES 15 3.39e-01 0.143000 0.63600
G ALPHA Z SIGNALLING EVENTS 45 9.90e-02 -0.142000 0.35900
INTERLEUKIN 6 FAMILY SIGNALING 19 2.84e-01 -0.142000 0.58700
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 23 2.40e-01 -0.142000 0.53900
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE 49 8.83e-02 -0.141000 0.34100
ASSEMBLY OF THE HIV VIRION 16 3.32e-01 -0.140000 0.63000
GLUCONEOGENESIS 27 2.08e-01 0.140000 0.51000
REPRESSION OF WNT TARGET GENES 14 3.65e-01 0.140000 0.65800
PROTEIN LOCALIZATION 157 2.52e-03 0.140000 0.05370
DUAL INCISION IN GG NER 41 1.23e-01 0.139000 0.39800
INACTIVATION OF CSF3 G CSF SIGNALING 24 2.38e-01 -0.139000 0.53900
TRANSLATION 286 5.46e-05 0.139000 0.00492
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION 25 2.30e-01 0.139000 0.52900
DCC MEDIATED ATTRACTIVE SIGNALING 14 3.70e-01 -0.138000 0.66100
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS 37 1.47e-01 -0.138000 0.43100
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 39 1.38e-01 0.137000 0.42500
ACTIVATION OF RAC1 13 3.94e-01 -0.137000 0.67900
VLDLR INTERNALISATION AND DEGRADATION 11 4.33e-01 0.137000 0.70700
DNA METHYLATION 21 2.79e-01 0.136000 0.58400
INTERLEUKIN 17 SIGNALING 67 5.40e-02 -0.136000 0.27800
RNA POLYMERASE III TRANSCRIPTION TERMINATION 23 2.59e-01 0.136000 0.56600
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE 19 3.06e-01 0.136000 0.60300
SIGNALING BY TGFB FAMILY MEMBERS 97 2.13e-02 -0.135000 0.18400
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING 26 2.33e-01 -0.135000 0.53200
EUKARYOTIC TRANSLATION ELONGATION 87 2.96e-02 0.135000 0.21500
LDL CLEARANCE 15 3.65e-01 -0.135000 0.65800
INTRACELLULAR SIGNALING BY SECOND MESSENGERS 282 1.03e-04 -0.135000 0.00753
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA 41 1.37e-01 0.134000 0.42500
BASIGIN INTERACTIONS 22 2.77e-01 0.134000 0.58300
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX 12 4.23e-01 0.134000 0.69900
RAP1 SIGNALLING 15 3.71e-01 -0.133000 0.66100
PROCESSING OF INTRONLESS PRE MRNAS 19 3.14e-01 -0.133000 0.60900
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS 15 3.71e-01 -0.133000 0.66100
SIGNALING BY TGF BETA RECEPTOR COMPLEX 72 5.05e-02 -0.133000 0.26800
SIGNALING BY NTRKS 129 8.98e-03 -0.133000 0.11200
SUMOYLATION 163 3.38e-03 -0.133000 0.06300
FORMATION OF TC NER PRE INCISION COMPLEX 53 9.44e-02 0.133000 0.34900
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS 362 1.48e-05 -0.133000 0.00217
G ALPHA 12 13 SIGNALLING EVENTS 74 4.90e-02 -0.132000 0.26400
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS 17 3.45e-01 -0.132000 0.64100
NEGATIVE REGULATION OF THE PI3K AKT NETWORK 93 2.76e-02 -0.132000 0.20900
VITAMIN B5 PANTOTHENATE METABOLISM 14 3.92e-01 0.132000 0.67900
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE 13 4.10e-01 0.132000 0.69000
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS 10 4.70e-01 0.132000 0.73500
PRE NOTCH PROCESSING IN GOLGI 18 3.33e-01 0.132000 0.63100
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE 23 2.75e-01 0.132000 0.58300
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION 11 4.50e-01 -0.131000 0.72100
NUCLEAR SIGNALING BY ERBB4 30 2.13e-01 0.131000 0.51800
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 10 4.72e-01 0.131000 0.73600
MYOGENESIS 24 2.67e-01 -0.131000 0.57700
CS DS DEGRADATION 14 3.97e-01 0.131000 0.67900
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS 13 4.14e-01 -0.131000 0.69100
BASE EXCISION REPAIR AP SITE FORMATION 30 2.17e-01 0.130000 0.51900
CLASS B 2 SECRETIN FAMILY RECEPTORS 70 6.05e-02 0.130000 0.29600
MAPK6 MAPK4 SIGNALING 83 4.12e-02 -0.130000 0.25400
FRS MEDIATED FGFR2 SIGNALING 18 3.43e-01 -0.129000 0.64100
POST CHAPERONIN TUBULIN FOLDING PATHWAY 17 3.58e-01 0.129000 0.65300
APOPTOTIC EXECUTION PHASE 46 1.32e-01 0.128000 0.41700
SODIUM CALCIUM EXCHANGERS 10 4.83e-01 -0.128000 0.74200
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION 21 3.11e-01 -0.128000 0.60300
RIP MEDIATED NFKB ACTIVATION VIA ZBP1 15 3.93e-01 -0.127000 0.67900
MYD88 INDEPENDENT TLR4 CASCADE 93 3.42e-02 -0.127000 0.23300
SHC1 EVENTS IN ERBB2 SIGNALING 20 3.25e-01 -0.127000 0.62300
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR 10 4.88e-01 0.127000 0.74800
ELEVATION OF CYTOSOLIC CA2 LEVELS 14 4.13e-01 0.126000 0.69100
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS 41 1.62e-01 -0.126000 0.44400
DISEASES OF DNA REPAIR 11 4.69e-01 -0.126000 0.73500
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 31 2.26e-01 0.126000 0.52400
BILE ACID AND BILE SALT METABOLISM 25 2.77e-01 0.126000 0.58300
SHC1 EVENTS IN EGFR SIGNALING 10 4.94e-01 -0.125000 0.75000
NEGATIVE REGULATION OF MET ACTIVITY 21 3.22e-01 -0.125000 0.61800
TNFR1 INDUCED PROAPOPTOTIC SIGNALING 12 4.56e-01 -0.124000 0.72400
SYNAPTIC ADHESION LIKE MOLECULES 21 3.26e-01 -0.124000 0.62300
ARACHIDONIC ACID METABOLISM 38 1.90e-01 0.123000 0.48200
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS 103 3.16e-02 0.123000 0.22300
VISUAL PHOTOTRANSDUCTION 58 1.07e-01 0.122000 0.36700
LGI ADAM INTERACTIONS 14 4.28e-01 -0.122000 0.70200
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE 63 9.36e-02 -0.122000 0.34700
GROWTH HORMONE RECEPTOR SIGNALING 20 3.45e-01 -0.122000 0.64100
FOXO MEDIATED TRANSCRIPTION 57 1.12e-01 -0.122000 0.37900
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER 59 1.06e-01 -0.122000 0.36700
TOLL LIKE RECEPTOR 9 TLR9 CASCADE 91 4.55e-02 -0.121000 0.26400
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS 24 3.05e-01 -0.121000 0.60300
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE 46 1.56e-01 0.121000 0.44000
NUCLEOTIDE EXCISION REPAIR 110 2.89e-02 0.121000 0.21300
CD28 DEPENDENT VAV1 PATHWAY 11 4.90e-01 -0.120000 0.74800
TRANSMISSION ACROSS CHEMICAL SYNAPSES 240 1.37e-03 -0.120000 0.03660
METABOLISM OF VITAMINS AND COFACTORS 152 1.09e-02 0.120000 0.12600
AQUAPORIN MEDIATED TRANSPORT 39 1.96e-01 -0.120000 0.49000
EPH EPHRIN SIGNALING 92 4.76e-02 -0.120000 0.26400
NICOTINATE METABOLISM 25 3.02e-01 0.119000 0.60200
SIGNALING BY EGFR 46 1.62e-01 -0.119000 0.44400
REPRODUCTION 74 7.64e-02 0.119000 0.32700
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS 11 4.94e-01 0.119000 0.75000
RET SIGNALING 35 2.25e-01 -0.118000 0.52400
SHC MEDIATED CASCADE FGFR1 14 4.44e-01 -0.118000 0.71700
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 20 3.61e-01 0.118000 0.65700
SIGNALING BY FLT3 ITD AND TKD MUTANTS 15 4.32e-01 0.117000 0.70700
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE 20 3.65e-01 0.117000 0.65800
REGULATION OF TP53 ACTIVITY 151 1.34e-02 -0.117000 0.14300
OXIDATIVE STRESS INDUCED SENESCENCE 79 7.32e-02 -0.117000 0.32300
SYNTHESIS OF PA 31 2.62e-01 -0.117000 0.57000
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS 30 2.69e-01 0.117000 0.57800
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM 79 7.51e-02 -0.116000 0.32500
TRNA PROCESSING IN THE NUCLEUS 56 1.34e-01 -0.116000 0.41800
INTEGRATION OF ENERGY METABOLISM 97 4.92e-02 -0.116000 0.26400
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES 45 1.80e-01 -0.115000 0.47200
INSULIN RECEPTOR SIGNALLING CASCADE 43 1.92e-01 -0.115000 0.48400
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 52 1.52e-01 -0.115000 0.43400
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS 83 7.15e-02 -0.114000 0.31800
PROLACTIN RECEPTOR SIGNALING 11 5.12e-01 0.114000 0.76100
SIGNALING BY PDGF 56 1.40e-01 -0.114000 0.43000
UB SPECIFIC PROCESSING PROTEASES 168 1.12e-02 -0.114000 0.12900
PHOSPHORYLATION OF THE APC C 18 4.06e-01 0.113000 0.68800
CDC42 GTPASE CYCLE 152 1.62e-02 -0.113000 0.15800
NF KB IS ACTIVATED AND SIGNALS SURVIVAL 13 4.82e-01 0.113000 0.74200
CARNITINE METABOLISM 14 4.66e-01 0.113000 0.73300
COLLAGEN DEGRADATION 52 1.61e-01 0.112000 0.44400
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION 16 4.38e-01 0.112000 0.70900
RHOBTB3 ATPASE CYCLE 10 5.41e-01 0.112000 0.78400
VIRAL MESSENGER RNA SYNTHESIS 42 2.11e-01 -0.112000 0.51500
SULFUR AMINO ACID METABOLISM 23 3.54e-01 0.112000 0.65200
METABOLISM OF FAT SOLUBLE VITAMINS 32 2.77e-01 0.111000 0.58300
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III 23 3.57e-01 0.111000 0.65300
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 172 1.24e-02 0.111000 0.13700
DISEASES OF METABOLISM 199 7.37e-03 0.110000 0.09820
FGFR1 MUTANT RECEPTOR ACTIVATION 25 3.40e-01 -0.110000 0.63700
NEURONAL SYSTEM 368 2.97e-04 -0.110000 0.01510
SIGNALING BY FGFR 72 1.07e-01 -0.110000 0.36700
RHOA GTPASE CYCLE 142 2.41e-02 -0.110000 0.19700
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 31 2.91e-01 -0.110000 0.58900
METABOLISM OF CARBOHYDRATES 258 2.48e-03 0.110000 0.05370
DEADENYLATION OF MRNA 25 3.44e-01 -0.109000 0.64100
PEROXISOMAL PROTEIN IMPORT 58 1.52e-01 0.109000 0.43500
PIWI INTERACTING RNA PIRNA BIOGENESIS 21 3.89e-01 -0.109000 0.67900
CD28 DEPENDENT PI3K AKT SIGNALING 21 3.91e-01 -0.108000 0.67900
NUCLEAR ENVELOPE BREAKDOWN 48 1.96e-01 -0.108000 0.49000
CYTOKINE SIGNALING IN IMMUNE SYSTEM 547 1.71e-05 -0.108000 0.00223
BASE EXCISION REPAIR 58 1.56e-01 0.108000 0.44000
CHAPERONE MEDIATED AUTOPHAGY 20 4.04e-01 0.108000 0.68800
SIGNALING BY FGFR2 IN DISEASE 36 2.65e-01 -0.107000 0.57400
BBSOME MEDIATED CARGO TARGETING TO CILIUM 23 3.74e-01 -0.107000 0.66500
GENE SILENCING BY RNA 86 8.68e-02 -0.107000 0.34100
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES 20 4.09e-01 0.107000 0.69000
PI3K AKT SIGNALING IN CANCER 87 8.56e-02 -0.107000 0.34100
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 32 2.97e-01 -0.106000 0.59600
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS 44 2.22e-01 -0.106000 0.52200
INHIBITION OF DNA RECOMBINATION AT TELOMERE 36 2.70e-01 0.106000 0.57800
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY 11 5.42e-01 -0.106000 0.78400
HCMV EARLY EVENTS 81 9.91e-02 -0.106000 0.35900
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS 19 4.25e-01 -0.106000 0.69900
DUAL INCISION IN TC NER 65 1.41e-01 0.106000 0.43000
FATTY ACYL COA BIOSYNTHESIS 32 3.03e-01 0.105000 0.60300
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS 14 4.97e-01 -0.105000 0.75100
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO 10 5.67e-01 -0.105000 0.79900
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R 43 2.35e-01 -0.105000 0.53600
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY 11 5.49e-01 -0.104000 0.78600
EUKARYOTIC TRANSLATION INITIATION 114 5.46e-02 0.104000 0.28000
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER 78 1.12e-01 0.104000 0.38000
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS 11 5.50e-01 -0.104000 0.78600
RAC1 GTPASE CYCLE 176 1.79e-02 -0.104000 0.16400
PI 3K CASCADE FGFR1 14 5.02e-01 -0.104000 0.75300
HS GAG DEGRADATION 20 4.24e-01 0.103000 0.69900
RHO GTPASES ACTIVATE PKNS 48 2.17e-01 0.103000 0.51900
PHOSPHOLIPID METABOLISM 190 1.46e-02 -0.103000 0.15100
SIGNALING BY INSULIN RECEPTOR 62 1.63e-01 -0.103000 0.44400
DEUBIQUITINATION 242 6.34e-03 -0.102000 0.08920
SIGNALING BY NODAL 17 4.67e-01 -0.102000 0.73300
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM 14 5.11e-01 -0.101000 0.76100
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 17 4.70e-01 -0.101000 0.73500
REGULATION OF INSULIN SECRETION 71 1.41e-01 -0.101000 0.43000
PARASITE INFECTION 56 1.91e-01 -0.101000 0.48300
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 12 5.46e-01 0.101000 0.78400
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS 34 3.10e-01 -0.101000 0.60300
ESR MEDIATED SIGNALING 164 2.63e-02 -0.101000 0.20600
VOLTAGE GATED POTASSIUM CHANNELS 40 2.71e-01 -0.101000 0.57900
PEPTIDE LIGAND BINDING RECEPTORS 91 9.78e-02 0.100000 0.35800
ACYL CHAIN REMODELLING OF PC 18 4.62e-01 -0.100000 0.73200
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX 10 5.85e-01 0.099800 0.81400
NRAGE SIGNALS DEATH THROUGH JNK 55 2.01e-01 -0.099700 0.49900
MRNA SPLICING MINOR PATHWAY 52 2.14e-01 0.099700 0.51800
TRANSCRIPTIONAL REGULATION BY RUNX2 110 7.12e-02 -0.099700 0.31800
DISEASES OF PROGRAMMED CELL DEATH 55 2.02e-01 0.099600 0.49900
INSULIN RECEPTOR RECYCLING 20 4.42e-01 -0.099200 0.71600
HEDGEHOG ON STATE 82 1.23e-01 -0.098700 0.39800
PTEN REGULATION 135 4.84e-02 -0.098500 0.26400
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP 65 1.73e-01 0.097800 0.46300
DEGRADATION OF THE EXTRACELLULAR MATRIX 106 8.43e-02 0.097100 0.33900
BETA CATENIN PHOSPHORYLATION CASCADE 16 5.02e-01 -0.096900 0.75300
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 16 5.05e-01 -0.096300 0.75500
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX 30 3.62e-01 0.096100 0.65800
SYNTHESIS OF BILE ACIDS AND BILE SALTS 22 4.36e-01 0.096000 0.70800
RNA POLYMERASE I TRANSCRIPTION TERMINATION 31 3.56e-01 0.095900 0.65200
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES 14 5.35e-01 -0.095800 0.78100
PROCESSING AND ACTIVATION OF SUMO 10 6.00e-01 0.095800 0.82500
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 34 3.34e-01 0.095700 0.63100
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION 38 3.08e-01 -0.095600 0.60300
SIGNALING BY CSF3 G CSF 29 3.74e-01 -0.095400 0.66500
REGULATION OF FZD BY UBIQUITINATION 19 4.73e-01 0.095100 0.73600
TRAFFICKING OF AMPA RECEPTORS 31 3.61e-01 -0.094900 0.65700
FLT3 SIGNALING IN DISEASE 27 3.94e-01 -0.094800 0.67900
SIGNAL TRANSDUCTION BY L1 21 4.53e-01 -0.094700 0.72100
RUNX3 REGULATES NOTCH SIGNALING 13 5.55e-01 0.094400 0.79300
DOWNREGULATION OF ERBB2 SIGNALING 27 3.96e-01 -0.094400 0.67900
METABOLISM OF FOLATE AND PTERINES 15 5.31e-01 0.093400 0.77800
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING 13 5.62e-01 -0.093000 0.79900
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 38 3.22e-01 -0.092900 0.61800
POLO LIKE KINASE MEDIATED EVENTS 13 5.63e-01 -0.092700 0.79900
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER 25 4.24e-01 0.092500 0.69900
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION 26 4.15e-01 -0.092400 0.69100
STRIATED MUSCLE CONTRACTION 26 4.16e-01 -0.092300 0.69100
SIGNALING BY NOTCH3 48 2.69e-01 -0.092200 0.57800
PLASMA LIPOPROTEIN REMODELING 15 5.37e-01 0.092100 0.78200
NONSENSE MEDIATED DECAY NMD 109 9.73e-02 0.092000 0.35700
DISEASES OF GLYCOSYLATION 124 7.71e-02 0.092000 0.32800
SUMOYLATION OF IMMUNE RESPONSE PROTEINS 11 5.97e-01 0.092000 0.82500
RRNA PROCESSING IN THE MITOCHONDRION 10 6.15e-01 0.091800 0.82700
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 43 3.02e-01 0.091100 0.60100
CGMP EFFECTS 15 5.43e-01 -0.090800 0.78400
HDMS DEMETHYLATE HISTONES 28 4.06e-01 -0.090800 0.68800
CA2 PATHWAY 56 2.40e-01 -0.090800 0.53900
RHO GTPASES ACTIVATE WASPS AND WAVES 36 3.47e-01 -0.090700 0.64200
NETRIN 1 SIGNALING 48 2.81e-01 -0.090000 0.58400
MRNA CAPPING 29 4.03e-01 0.089800 0.68700
RNA POLYMERASE II TRANSCRIPTION TERMINATION 65 2.12e-01 -0.089500 0.51700
SIGNALING BY THE B CELL RECEPTOR BCR 103 1.17e-01 -0.089500 0.38500
SIGNALING BY FGFR IN DISEASE 55 2.51e-01 -0.089500 0.55300
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 21 4.79e-01 -0.089300 0.74200
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS 73 1.88e-01 -0.089100 0.47700
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION 18 5.13e-01 -0.089000 0.76100
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX 11 6.11e-01 0.088600 0.82500
DEATH RECEPTOR SIGNALLING 133 8.12e-02 -0.087700 0.33600
REGULATION OF IFNG SIGNALING 13 5.84e-01 -0.087600 0.81400
KILLING MECHANISMS 10 6.32e-01 -0.087600 0.83400
RESOLUTION OF ABASIC SITES AP SITES 38 3.56e-01 0.086600 0.65200
TRANSCRIPTIONAL REGULATION BY RUNX1 179 4.62e-02 -0.086500 0.26400
RHOB GTPASE CYCLE 67 2.21e-01 -0.086400 0.52200
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 12 6.04e-01 -0.086400 0.82500
PI3K EVENTS IN ERBB2 SIGNALING 14 5.78e-01 -0.085900 0.80900
SYNDECAN INTERACTIONS 26 4.50e-01 0.085600 0.72100
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4 18 5.32e-01 -0.085100 0.77800
SUMOYLATION OF TRANSCRIPTION FACTORS 17 5.44e-01 -0.085100 0.78400
PECAM1 INTERACTIONS 12 6.10e-01 -0.085000 0.82500
FC EPSILON RECEPTOR FCERI SIGNALING 122 1.06e-01 -0.084900 0.36700
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION 87 1.74e-01 -0.084400 0.46300
REGULATION OF GENE EXPRESSION IN BETA CELLS 10 6.44e-01 -0.084300 0.83800
METABOLISM OF STEROID HORMONES 20 5.14e-01 0.084300 0.76100
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE 22 4.95e-01 0.084000 0.75000
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM 10 6.46e-01 -0.083800 0.83800
SIGNALING BY HEDGEHOG 141 8.65e-02 -0.083700 0.34100
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10 11 6.32e-01 -0.083300 0.83400
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION 31 4.24e-01 0.083100 0.69900
FLT3 SIGNALING 37 3.84e-01 -0.082800 0.67500
RECEPTOR MEDIATED MITOPHAGY 11 6.35e-01 -0.082700 0.83700
NEGATIVE REGULATION OF FGFR2 SIGNALING 27 4.58e-01 -0.082500 0.72600
RESPIRATORY ELECTRON TRANSPORT 102 1.51e-01 0.082400 0.43300
METABOLISM OF COFACTORS 18 5.45e-01 0.082400 0.78400
REGULATION OF RAS BY GAPS 66 2.51e-01 -0.081800 0.55300
REDUCTION OF CYTOSOLIC CA LEVELS 12 6.25e-01 -0.081400 0.83100
DARPP 32 EVENTS 23 4.99e-01 -0.081400 0.75200
SIGNALING BY RECEPTOR TYROSINE KINASES 462 2.84e-03 -0.081300 0.05640
REGULATION OF TLR BY ENDOGENOUS LIGAND 12 6.26e-01 0.081200 0.83100
SUMOYLATION OF INTRACELLULAR RECEPTORS 25 4.83e-01 0.081200 0.74200
RNA POLYMERASE I TRANSCRIPTION 68 2.47e-01 0.081200 0.55100
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN 12 6.29e-01 0.080600 0.83300
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE 92 1.82e-01 -0.080500 0.47200
SCAVENGING BY CLASS A RECEPTORS 14 6.02e-01 0.080500 0.82500
HS GAG BIOSYNTHESIS 30 4.46e-01 0.080400 0.71800
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE 15 5.90e-01 0.080400 0.82000
NERVOUS SYSTEM DEVELOPMENT 543 1.44e-03 -0.080300 0.03750
SIGNALING BY FGFR2 62 2.79e-01 -0.079600 0.58400
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 59 2.91e-01 0.079400 0.58900
L1CAM INTERACTIONS 107 1.57e-01 -0.079200 0.44200
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY 69 2.56e-01 -0.079200 0.56100
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY 41 3.82e-01 -0.078900 0.67300
CYCLIN D ASSOCIATED EVENTS IN G1 46 3.55e-01 0.078800 0.65200
RHO GTPASE CYCLE 425 5.50e-03 -0.078700 0.08340
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 125 1.29e-01 0.078700 0.41100
DNA REPLICATION 122 1.34e-01 0.078600 0.41800
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING 83 2.20e-01 -0.078000 0.52100
SIGNALING BY FGFR4 32 4.46e-01 -0.077900 0.71800
POTENTIAL THERAPEUTICS FOR SARS 77 2.39e-01 -0.077700 0.53900
RNA POLYMERASE II TRANSCRIPTION 1089 1.91e-05 -0.077300 0.00224
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES 23 5.21e-01 -0.077300 0.76700
PYRIMIDINE SALVAGE 10 6.73e-01 0.077000 0.85500
ACYL CHAIN REMODELLING OF PG 11 6.59e-01 -0.076900 0.84500
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION 15 6.07e-01 0.076800 0.82500
REGULATED PROTEOLYSIS OF P75NTR 12 6.46e-01 -0.076500 0.83800
SIGNALING BY FGFR2 IIIA TM 19 5.65e-01 0.076200 0.79900
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL 15 6.09e-01 -0.076200 0.82500
OLFACTORY SIGNALING PATHWAY 27 4.94e-01 -0.076100 0.75000
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE 87 2.21e-01 0.075900 0.52200
REGULATION OF PTEN GENE TRANSCRIPTION 60 3.10e-01 -0.075800 0.60300
RESOLUTION OF SISTER CHROMATID COHESION 103 1.86e-01 -0.075400 0.47400
GLYCOSPHINGOLIPID METABOLISM 39 4.15e-01 0.075400 0.69100
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY 95 2.06e-01 0.075200 0.50700
BUDDING AND MATURATION OF HIV VIRION 27 4.99e-01 0.075100 0.75200
RHO GTPASES ACTIVATE FORMINS 121 1.55e-01 -0.074900 0.44000
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 108 1.80e-01 0.074700 0.47200
ION TRANSPORT BY P TYPE ATPASES 47 3.77e-01 0.074600 0.66800
REGULATION OF PTEN STABILITY AND ACTIVITY 66 2.98e-01 -0.074100 0.59700
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 23 5.39e-01 -0.074000 0.78200
GPCR LIGAND BINDING 243 4.74e-02 0.074000 0.26400
SIGNALING BY NOTCH 190 7.99e-02 -0.073800 0.33300
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY 15 6.22e-01 -0.073500 0.83100
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE 39 4.27e-01 0.073500 0.70100
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS 51 3.66e-01 0.073200 0.65800
RND3 GTPASE CYCLE 38 4.35e-01 -0.073100 0.70800
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY 63 3.18e-01 0.072800 0.61300
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS 84 2.49e-01 0.072800 0.55300
PROTEIN FOLDING 89 2.36e-01 -0.072700 0.53600
PREGNENOLONE BIOSYNTHESIS 12 6.64e-01 -0.072500 0.84800
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST 13 6.52e-01 -0.072300 0.83900
O LINKED GLYCOSYLATION 87 2.46e-01 0.072000 0.54800
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS 32 4.82e-01 -0.071900 0.74200
LATE ENDOSOMAL MICROAUTOPHAGY 31 4.89e-01 0.071800 0.74800
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 71 2.97e-01 0.071600 0.59600
MTOR SIGNALLING 40 4.34e-01 0.071500 0.70700
SIGNALING BY WNT 268 4.54e-02 -0.071100 0.26400
SARS COV INFECTIONS 140 1.48e-01 -0.070900 0.43100
GLYCEROPHOSPHOLIPID BIOSYNTHESIS 111 2.01e-01 -0.070300 0.49900
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS 83 2.71e-01 0.070000 0.57900
MITOTIC SPINDLE CHECKPOINT 100 2.27e-01 -0.069900 0.52700
CHROMOSOME MAINTENANCE 103 2.21e-01 0.069800 0.52200
APOPTOTIC FACTOR MEDIATED RESPONSE 18 6.10e-01 -0.069400 0.82500
SIGNALING BY HIPPO 20 5.92e-01 -0.069200 0.82100
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS 57 3.66e-01 0.069200 0.65800
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 83 2.77e-01 -0.069000 0.58300
SUPPRESSION OF PHAGOSOMAL MATURATION 13 6.67e-01 -0.068900 0.85100
REGULATION OF LIPID METABOLISM BY PPARALPHA 108 2.22e-01 -0.068100 0.52200
SPHINGOLIPID DE NOVO BIOSYNTHESIS 41 4.51e-01 -0.068000 0.72100
COSTIMULATION BY THE CD28 FAMILY 49 4.12e-01 -0.067800 0.69100
DISEASES OF IMMUNE SYSTEM 24 5.66e-01 -0.067600 0.79900
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS 20 6.01e-01 -0.067600 0.82500
HIV ELONGATION ARREST AND RECOVERY 32 5.09e-01 0.067500 0.75900
REGULATION OF EXPRESSION OF SLITS AND ROBOS 159 1.43e-01 0.067400 0.43000
SEMA4D IN SEMAPHORIN SIGNALING 24 5.70e-01 -0.067000 0.80100
RMTS METHYLATE HISTONE ARGININES 44 4.43e-01 -0.066900 0.71600
FRS MEDIATED FGFR3 SIGNALING 15 6.54e-01 0.066900 0.84100
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE 49 4.24e-01 0.066100 0.69900
S PHASE 156 1.56e-01 0.065900 0.44000
O LINKED GLYCOSYLATION OF MUCINS 41 4.67e-01 0.065700 0.73300
P75 NTR RECEPTOR MEDIATED SIGNALLING 94 2.72e-01 -0.065500 0.58000
LYSOSPHINGOLIPID AND LPA RECEPTORS 12 6.95e-01 -0.065500 0.86400
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 17 6.41e-01 0.065300 0.83700
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3 630 5.70e-03 -0.064800 0.08460
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION 33 5.20e-01 0.064800 0.76600
SIGNALING BY INTERLEUKINS 351 3.78e-02 -0.064700 0.24800
NEPHRIN FAMILY INTERACTIONS 22 6.00e-01 -0.064500 0.82500
SYNTHESIS OF PC 26 5.69e-01 -0.064500 0.80100
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 33 5.23e-01 0.064300 0.76800
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES 85 3.07e-01 0.064100 0.60300
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND 14 6.78e-01 -0.064100 0.85900
METABOLISM OF STEROIDS 113 2.40e-01 -0.064000 0.53900
HATS ACETYLATE HISTONES 93 2.88e-01 -0.063800 0.58700
SIGNALING BY NOTCH4 83 3.16e-01 0.063700 0.61100
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS 19 6.37e-01 0.062500 0.83700
SARS COV 2 INFECTION 65 3.85e-01 -0.062400 0.67600
TRNA AMINOACYLATION 42 4.85e-01 0.062200 0.74500
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS 36 5.20e-01 0.062000 0.76600
RESOLUTION OF D LOOP STRUCTURES 30 5.57e-01 0.062000 0.79300
TELOMERE C STRAND LAGGING STRAND SYNTHESIS 33 5.38e-01 0.061900 0.78200
N GLYCAN ANTENNAE ELONGATION 15 6.79e-01 -0.061800 0.85900
G ALPHA I SIGNALLING EVENTS 190 1.43e-01 -0.061700 0.43000
TRANSCRIPTIONAL REGULATION BY VENTX 36 5.23e-01 -0.061600 0.76800
EPH EPHRIN MEDIATED REPULSION OF CELLS 51 4.47e-01 -0.061500 0.71900
RHOJ GTPASE CYCLE 54 4.37e-01 -0.061200 0.70800
SCF SKP2 MEDIATED DEGRADATION OF P27 P21 60 4.13e-01 0.061200 0.69100
CLASS A 1 RHODOPSIN LIKE RECEPTORS 162 1.80e-01 0.061200 0.47200
DEFECTIVE EXT2 CAUSES EXOSTOSES 2 14 6.92e-01 0.061100 0.86400
HCMV INFECTION 104 2.83e-01 -0.061000 0.58700
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION 51 4.52e-01 -0.060900 0.72100
SLC TRANSPORTER DISORDERS 71 3.76e-01 -0.060800 0.66700
NUCLEOBASE BIOSYNTHESIS 15 6.84e-01 0.060700 0.86100
DEFECTS IN COBALAMIN B12 METABOLISM 13 7.05e-01 -0.060700 0.86800
RRNA PROCESSING 194 1.48e-01 0.060300 0.43100
ASYMMETRIC LOCALIZATION OF PCP PROTEINS 62 4.12e-01 0.060200 0.69100
ACTIVATION OF THE PRE REPLICATIVE COMPLEX 29 5.75e-01 0.060100 0.80600
ESTROGEN DEPENDENT GENE EXPRESSION 103 2.92e-01 -0.060100 0.58900
TBC RABGAPS 43 4.96e-01 -0.060000 0.75100
NONHOMOLOGOUS END JOINING NHEJ 44 4.91e-01 -0.060000 0.74800
INTERLEUKIN 7 SIGNALING 20 6.42e-01 0.060000 0.83700
PLATELET HOMEOSTASIS 78 3.63e-01 -0.059600 0.65800
CELL CELL JUNCTION ORGANIZATION 51 4.63e-01 0.059400 0.73200
MHC CLASS II ANTIGEN PRESENTATION 101 3.04e-01 0.059200 0.60300
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE 25 6.10e-01 0.059000 0.82500
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 106 2.96e-01 0.058800 0.59600
METALLOPROTEASE DUBS 26 6.05e-01 0.058700 0.82500
RHO GTPASES ACTIVATE NADPH OXIDASES 19 6.60e-01 0.058400 0.84500
TELOMERE EXTENSION BY TELOMERASE 22 6.36e-01 -0.058300 0.83700
CELLULAR RESPONSE TO CHEMICAL STRESS 150 2.19e-01 0.058200 0.52100
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 92 3.37e-01 0.058000 0.63400
SIGNALING BY WNT IN CANCER 30 5.83e-01 0.058000 0.81300
GLYCOGEN SYNTHESIS 14 7.08e-01 -0.057800 0.87000
SLC MEDIATED TRANSMEMBRANE TRANSPORT 185 1.79e-01 0.057400 0.47100
SNRNP ASSEMBLY 51 4.80e-01 -0.057200 0.74200
POTASSIUM CHANNELS 90 3.51e-01 -0.056900 0.64800
FRS MEDIATED FGFR1 SIGNALING 16 6.95e-01 -0.056700 0.86400
EXTRACELLULAR MATRIX ORGANIZATION 242 1.30e-01 0.056600 0.41300
FGFR2 ALTERNATIVE SPLICING 25 6.25e-01 -0.056500 0.83100
MISMATCH REPAIR 14 7.18e-01 0.055800 0.87500
HDACS DEACETYLATE HISTONES 47 5.09e-01 -0.055700 0.75900
CELLULAR RESPONSE TO STARVATION 146 2.49e-01 0.055300 0.55300
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES 63 4.48e-01 -0.055300 0.71900
PEPTIDE HORMONE METABOLISM 57 4.71e-01 -0.055200 0.73500
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 78 4.01e-01 -0.055100 0.68400
TRP CHANNELS 18 6.87e-01 -0.054900 0.86200
LYSOSOME VESICLE BIOGENESIS 32 5.92e-01 0.054800 0.82100
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 77 4.06e-01 -0.054800 0.68800
AURKA ACTIVATION BY TPX2 71 4.28e-01 0.054500 0.70100
DEVELOPMENTAL BIOLOGY 814 9.01e-03 -0.054200 0.11200
IRON UPTAKE AND TRANSPORT 52 5.00e-01 0.054000 0.75200
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER 60 4.71e-01 -0.053900 0.73500
AMINE LIGAND BINDING RECEPTORS 29 6.16e-01 0.053800 0.82700
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 84 3.94e-01 -0.053800 0.67900
RHO GTPASES ACTIVATE CIT 18 6.93e-01 0.053700 0.86400
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 26 6.36e-01 0.053600 0.83700
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX 32 6.01e-01 -0.053500 0.82500
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION 11 7.59e-01 0.053300 0.90400
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 64 4.64e-01 0.052900 0.73200
DISEASES OF MITOTIC CELL CYCLE 38 5.73e-01 0.052900 0.80300
UCH PROTEINASES 89 3.89e-01 0.052800 0.67900
HOST INTERACTIONS OF HIV FACTORS 122 3.15e-01 -0.052700 0.61100
KSRP KHSRP BINDS AND DESTABILIZES MRNA 16 7.15e-01 -0.052700 0.87400
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 78 4.24e-01 0.052400 0.69900
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION 27 6.40e-01 -0.052000 0.83700
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX 18 7.03e-01 0.051900 0.86800
FGFR2 LIGAND BINDING AND ACTIVATION 11 7.66e-01 -0.051900 0.90500
ORC1 REMOVAL FROM CHROMATIN 67 4.64e-01 0.051800 0.73200
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 30 6.25e-01 0.051600 0.83100
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 26 6.50e-01 -0.051400 0.83900
INTERLEUKIN 37 SIGNALING 18 7.06e-01 -0.051400 0.86800
G ALPHA Q SIGNALLING EVENTS 147 2.86e-01 -0.051000 0.58700
TELOMERE MAINTENANCE 79 4.34e-01 0.051000 0.70700
SIGNALING BY FGFR3 35 6.02e-01 -0.050900 0.82500
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY 85 4.19e-01 0.050800 0.69500
GLYCOLYSIS 66 4.77e-01 -0.050600 0.74100
RHOC GTPASE CYCLE 73 4.56e-01 -0.050500 0.72400
INTERLEUKIN 12 SIGNALING 37 5.97e-01 0.050300 0.82500
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE 19 7.05e-01 0.050200 0.86800
CRISTAE FORMATION 31 6.29e-01 0.050100 0.83300
COMPLEX I BIOGENESIS 56 5.17e-01 0.050000 0.76400
DNA REPAIR 294 1.41e-01 0.050000 0.43000
PROCESSING OF CAPPED INTRONLESS PRE MRNA 28 6.47e-01 -0.050000 0.83800
SIGNALING BY MET 76 4.55e-01 -0.049600 0.72400
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION 23 6.80e-01 0.049600 0.85900
MITOCHONDRIAL TRNA AMINOACYLATION 21 6.94e-01 0.049500 0.86400
ANTIGEN PROCESSING CROSS PRESENTATION 93 4.10e-01 -0.049500 0.69000
PRC2 METHYLATES HISTONES AND DNA 30 6.42e-01 0.049100 0.83700
ECM PROTEOGLYCANS 66 4.91e-01 0.049000 0.74800
EPHA MEDIATED GROWTH CONE COLLAPSE 29 6.49e-01 -0.048800 0.83800
EPIGENETIC REGULATION OF GENE EXPRESSION 104 3.95e-01 -0.048400 0.67900
NEGATIVE REGULATION OF NOTCH4 SIGNALING 54 5.39e-01 0.048300 0.78200
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION 16 7.38e-01 0.048300 0.88900
BLOOD GROUP SYSTEMS BIOSYNTHESIS 12 7.73e-01 0.048100 0.90700
TERMINATION OF TRANSLESION DNA SYNTHESIS 32 6.40e-01 0.047800 0.83700
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE 15 7.49e-01 -0.047700 0.89900
INTERLEUKIN 15 SIGNALING 13 7.66e-01 0.047600 0.90500
PHASE 4 RESTING MEMBRANE POTENTIAL 13 7.66e-01 0.047600 0.90500
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS 67 5.01e-01 -0.047600 0.75300
NEUROTRANSMITTER RELEASE CYCLE 49 5.66e-01 -0.047400 0.79900
TOLL LIKE RECEPTOR CASCADES 137 3.39e-01 -0.047400 0.63600
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 12 7.78e-01 -0.047100 0.90800
SENSORY PERCEPTION 144 3.30e-01 0.047100 0.62800
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA 15 7.53e-01 0.047000 0.90000
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 73 4.89e-01 -0.046900 0.74800
SIGNALING BY ERBB4 56 5.45e-01 -0.046800 0.78400
SIGNALING BY PTK6 51 5.66e-01 -0.046500 0.79900
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND 10 7.99e-01 0.046500 0.92000
TRIGLYCERIDE CATABOLISM 14 7.64e-01 0.046300 0.90500
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3 20 7.22e-01 -0.046000 0.87700
METABOLISM OF PORPHYRINS 19 7.29e-01 0.045900 0.88400
NEGATIVE REGULATION OF FGFR3 SIGNALING 24 6.98e-01 0.045800 0.86700
SIGNALING BY LEPTIN 10 8.04e-01 0.045300 0.92300
ORGANELLE BIOGENESIS AND MAINTENANCE 282 1.93e-01 -0.045200 0.48500
MET PROMOTES CELL MOTILITY 40 6.24e-01 -0.044800 0.83100
GLYCOGEN METABOLISM 25 6.99e-01 -0.044600 0.86700
ROS AND RNS PRODUCTION IN PHAGOCYTES 29 6.78e-01 0.044500 0.85900
RAB REGULATION OF TRAFFICKING 120 4.05e-01 -0.044100 0.68800
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST 15 7.68e-01 -0.044000 0.90500
TRANSCRIPTION OF THE HIV GENOME 67 5.36e-01 0.043700 0.78200
PLATELET AGGREGATION PLUG FORMATION 32 6.71e-01 -0.043500 0.85300
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 345 1.68e-01 -0.043300 0.45400
PHASE 0 RAPID DEPOLARISATION 29 6.91e-01 -0.042700 0.86400
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 66 5.50e-01 0.042600 0.78600
IRAK4 DEFICIENCY TLR2 4 13 7.91e-01 0.042400 0.91400
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION 48 6.12e-01 0.042300 0.82600
COLLAGEN FORMATION 80 5.14e-01 -0.042200 0.76100
FORMATION OF RNA POL II ELONGATION COMPLEX 57 5.82e-01 0.042100 0.81300
ADHERENS JUNCTIONS INTERACTIONS 31 6.85e-01 -0.042100 0.86100
DNA DAMAGE BYPASS 48 6.14e-01 0.042100 0.82700
P75NTR SIGNALS VIA NF KB 16 7.71e-01 0.042000 0.90600
CROSSLINKING OF COLLAGEN FIBRILS 17 7.64e-01 0.042000 0.90500
INFLAMMASOMES 19 7.52e-01 0.041900 0.90000
PROTEIN UBIQUITINATION 69 5.49e-01 -0.041700 0.78600
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING 26 7.14e-01 -0.041500 0.87400
ERBB2 ACTIVATES PTK6 SIGNALING 11 8.12e-01 0.041400 0.92600
GRB2 EVENTS IN ERBB2 SIGNALING 14 7.90e-01 -0.041100 0.91400
CELLULAR SENESCENCE 145 3.94e-01 -0.041000 0.67900
DEADENYLATION DEPENDENT MRNA DECAY 55 6.00e-01 -0.040900 0.82500
PCP CE PATHWAY 90 5.06e-01 0.040600 0.75600
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 28 7.15e-01 0.039900 0.87400
GLYCOGEN STORAGE DISEASES 12 8.12e-01 0.039700 0.92600
SIGNALING BY NOTCH2 33 6.94e-01 0.039600 0.86400
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 8.06e-01 -0.039400 0.92300
HIV TRANSCRIPTION INITIATION 45 6.48e-01 0.039300 0.83800
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL 59 6.05e-01 0.038900 0.82500
C TYPE LECTIN RECEPTORS CLRS 111 4.83e-01 -0.038600 0.74200
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 7.96e-01 0.038500 0.92000
P75NTR RECRUITS SIGNALLING COMPLEXES 13 8.10e-01 0.038500 0.92600
DEGRADATION OF DVL 55 6.22e-01 -0.038400 0.83100
HDR THROUGH MMEJ ALT NHEJ 10 8.34e-01 -0.038200 0.93700
RHOH GTPASE CYCLE 37 6.91e-01 0.037800 0.86400
LEISHMANIA INFECTION 191 3.71e-01 -0.037600 0.66100
RAB GEFS EXCHANGE GTP FOR GDP ON RABS 89 5.43e-01 -0.037300 0.78400
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 48 6.57e-01 0.037100 0.84400
AMYLOID FIBER FORMATION 58 6.32e-01 0.036400 0.83400
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION 84 5.68e-01 0.036000 0.80000
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA 16 8.06e-01 0.035600 0.92300
PI 3K CASCADE FGFR3 13 8.25e-01 0.035400 0.93300
RAB GERANYLGERANYLATION 59 6.40e-01 0.035200 0.83700
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS 72 6.07e-01 -0.035100 0.82500
DNA REPLICATION PRE INITIATION 79 5.93e-01 0.034800 0.82100
TRANSPORT OF SMALL MOLECULES 568 1.59e-01 0.034700 0.44400
ADAPTIVE IMMUNE SYSTEM 603 1.48e-01 -0.034600 0.43100
TRANSCRIPTIONAL REGULATION BY TP53 342 2.80e-01 -0.034100 0.58400
SHC1 EVENTS IN ERBB4 SIGNALING 12 8.38e-01 -0.034000 0.93900
NEDDYLATION 219 3.92e-01 0.033600 0.67900
ASPARAGINE N LINKED GLYCOSYLATION 283 3.33e-01 -0.033500 0.63000
ION CHANNEL TRANSPORT 139 5.00e-01 0.033200 0.75200
SIGNALING BY GPCR 458 2.26e-01 -0.033100 0.52400
COPII MEDIATED VESICLE TRANSPORT 65 6.45e-01 0.033100 0.83800
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS 14 8.32e-01 0.032700 0.93600
NEGATIVE REGULATION OF FGFR1 SIGNALING 25 7.78e-01 -0.032500 0.90900
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX 10 8.59e-01 0.032400 0.94600
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 288 3.45e-01 -0.032400 0.64100
SHC MEDIATED CASCADE FGFR4 11 8.53e-01 -0.032200 0.94300
HEDGEHOG OFF STATE 106 5.67e-01 -0.032200 0.79900
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 86 6.08e-01 0.032100 0.82500
STABILIZATION OF P53 54 6.85e-01 -0.031900 0.86100
GPVI MEDIATED ACTIVATION CASCADE 31 7.60e-01 -0.031700 0.90400
ION HOMEOSTASIS 49 7.02e-01 -0.031600 0.86800
CELL CYCLE CHECKPOINTS 245 3.96e-01 -0.031500 0.67900
RHO GTPASE EFFECTORS 251 3.91e-01 -0.031500 0.67900
SENSORY PROCESSING OF SOUND 61 6.71e-01 0.031500 0.85300
INTEGRIN CELL SURFACE INTERACTIONS 71 6.51e-01 0.031100 0.83900
FCGR ACTIVATION 10 8.65e-01 -0.031000 0.94800
RHO GTPASES ACTIVATE ROCKS 19 8.17e-01 0.030700 0.92900
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT 177 4.82e-01 -0.030700 0.74200
PLATELET CALCIUM HOMEOSTASIS 26 7.88e-01 0.030500 0.91300
TNFR2 NON CANONICAL NF KB PATHWAY 80 6.39e-01 -0.030300 0.83700
FRS MEDIATED FGFR4 SIGNALING 13 8.51e-01 0.030100 0.94300
MITOTIC PROPHASE 94 6.15e-01 -0.030100 0.82700
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY 53 7.12e-01 -0.029300 0.87300
RND1 GTPASE CYCLE 38 7.55e-01 -0.029300 0.90100
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS 49 7.23e-01 -0.029300 0.87700
INFECTIOUS DISEASE 724 1.82e-01 -0.029300 0.47200
E2F MEDIATED REGULATION OF DNA REPLICATION 19 8.29e-01 -0.028600 0.93500
MITOTIC G1 PHASE AND G1 S TRANSITION 142 5.57e-01 0.028600 0.79300
RECYCLING PATHWAY OF L1 40 7.55e-01 0.028500 0.90100
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 62 6.98e-01 0.028500 0.86700
KINESINS 48 7.33e-01 -0.028400 0.88700
RHO GTPASES ACTIVATE IQGAPS 23 8.14e-01 -0.028400 0.92600
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR 63 7.04e-01 0.027700 0.86800
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 20 8.31e-01 0.027600 0.93500
IRAK1 RECRUITS IKK COMPLEX 14 8.61e-01 -0.027100 0.94600
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION 112 6.22e-01 -0.027000 0.83100
RAC3 GTPASE CYCLE 88 6.64e-01 0.026800 0.84800
NEGATIVE REGULATION OF FLT3 15 8.58e-01 0.026800 0.94500
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES 53 7.37e-01 -0.026700 0.88900
TRANSCRIPTIONAL REGULATION BY SMALL RNAS 62 7.16e-01 -0.026700 0.87500
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS 12 8.73e-01 0.026600 0.95200
GLUCAGON TYPE LIGAND RECEPTORS 25 8.22e-01 -0.026000 0.93100
METABOLISM OF POLYAMINES 56 7.37e-01 0.025900 0.88900
HDR THROUGH SINGLE STRAND ANNEALING SSA 36 7.88e-01 0.025900 0.91300
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC 44 7.68e-01 -0.025700 0.90500
BETA CATENIN INDEPENDENT WNT SIGNALING 138 6.03e-01 -0.025700 0.82500
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL 26 8.21e-01 0.025600 0.93100
INNATE IMMUNE SYSTEM 780 2.29e-01 -0.025500 0.52900
NR1H2 AND NR1H3 MEDIATED SIGNALING 38 7.86e-01 -0.025400 0.91300
STIMULI SENSING CHANNELS 75 7.05e-01 0.025300 0.86800
PLATELET ACTIVATION SIGNALING AND AGGREGATION 224 5.14e-01 -0.025300 0.76100
SPRY REGULATION OF FGF SIGNALING 16 8.61e-01 -0.025200 0.94600
INTRA GOLGI TRAFFIC 43 7.76e-01 -0.025100 0.90800
MEMBRANE TRAFFICKING 578 3.08e-01 -0.024900 0.60300
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1 15 8.68e-01 -0.024700 0.94800
SIGNALING BY NUCLEAR RECEPTORS 221 5.27e-01 -0.024700 0.77200
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES 29 8.18e-01 -0.024700 0.93000
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 46 7.73e-01 0.024600 0.90700
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 22 8.42e-01 -0.024600 0.94100
SIGNALING BY ROBO RECEPTORS 204 5.47e-01 0.024500 0.78600
G1 S DNA DAMAGE CHECKPOINTS 65 7.34e-01 -0.024400 0.88700
AGGREPHAGY 35 8.03e-01 0.024400 0.92200
PINK1 PRKN MEDIATED MITOPHAGY 22 8.44e-01 0.024200 0.94100
PROGRAMMED CELL DEATH 188 5.80e-01 0.023400 0.81100
DNA DOUBLE STRAND BREAK RESPONSE 53 7.70e-01 0.023200 0.90600
TP53 REGULATES METABOLIC GENES 85 7.12e-01 -0.023200 0.87300
RESPONSE OF MTB TO PHAGOCYTOSIS 22 8.51e-01 -0.023200 0.94300
HEME BIOSYNTHESIS 13 8.85e-01 -0.023200 0.95500
VESICLE MEDIATED TRANSPORT 609 3.33e-01 -0.023100 0.63000
CELLULAR RESPONSE TO HYPOXIA 72 7.35e-01 0.023100 0.88800
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA 59 7.61e-01 -0.022900 0.90500
NON INTEGRIN MEMBRANE ECM INTERACTIONS 57 7.69e-01 -0.022500 0.90600
REGULATION OF BETA CELL DEVELOPMENT 26 8.43e-01 -0.022500 0.94100
SEPARATION OF SISTER CHROMATIDS 169 6.16e-01 -0.022400 0.82700
THE PHOTOTRANSDUCTION CASCADE 19 8.67e-01 0.022300 0.94800
NEGATIVE REGULATION OF FGFR4 SIGNALING 22 8.58e-01 0.022100 0.94500
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES 30 8.35e-01 -0.022000 0.93700
RIPK1 MEDIATED REGULATED NECROSIS 25 8.49e-01 -0.022000 0.94300
JOSEPHIN DOMAIN DUBS 11 9.00e-01 -0.022000 0.96000
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA 24 8.53e-01 0.021800 0.94300
CELLULAR RESPONSES TO EXTERNAL STIMULI 605 3.65e-01 -0.021700 0.65800
RNA POLYMERASE I TRANSCRIPTION INITIATION 47 8.00e-01 -0.021400 0.92000
DISORDERS OF TRANSMEMBRANE TRANSPORTERS 140 6.67e-01 -0.021100 0.85100
G2 M DNA DAMAGE CHECKPOINT 66 7.74e-01 -0.020400 0.90700
CLATHRIN MEDIATED ENDOCYTOSIS 132 6.88e-01 -0.020300 0.86300
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 18 8.82e-01 -0.020200 0.95500
TRNA PROCESSING 105 7.23e-01 -0.020000 0.87700
CELL CELL COMMUNICATION 109 7.18e-01 -0.020000 0.87500
CARGO CONCENTRATION IN THE ER 30 8.50e-01 -0.020000 0.94300
ABC TRANSPORTER DISORDERS 69 7.74e-01 0.020000 0.90700
TELOMERE C STRAND SYNTHESIS INITIATION 13 9.01e-01 0.019800 0.96000
INFLUENZA INFECTION 145 6.81e-01 -0.019800 0.85900
SHC MEDIATED CASCADE FGFR3 13 9.02e-01 0.019800 0.96000
MITOTIC METAPHASE AND ANAPHASE 209 6.26e-01 -0.019600 0.83100
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING 10 9.15e-01 0.019500 0.96400
HCMV LATE EVENTS 66 7.85e-01 -0.019400 0.91300
RHO GTPASES ACTIVATE PAKS 21 8.78e-01 -0.019400 0.95300
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX 82 7.63e-01 0.019200 0.90500
G1 S SPECIFIC TRANSCRIPTION 26 8.65e-01 -0.019200 0.94800
ZINC TRANSPORTERS 15 8.98e-01 -0.019200 0.96000
APOPTOSIS 166 6.73e-01 0.019000 0.85500
SELECTIVE AUTOPHAGY 72 7.81e-01 -0.018900 0.91100
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX 47 8.24e-01 -0.018700 0.93200
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA 53 8.20e-01 -0.018100 0.93100
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY 24 8.78e-01 -0.018000 0.95300
G0 AND EARLY G1 25 8.77e-01 0.017900 0.95300
HOMOLOGY DIRECTED REPAIR 109 7.47e-01 -0.017900 0.89700
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS 17 8.99e-01 0.017800 0.96000
CARDIAC CONDUCTION 107 7.51e-01 -0.017800 0.90000
AMINO ACIDS REGULATE MTORC1 51 8.28e-01 0.017600 0.93400
DNA DOUBLE STRAND BREAK REPAIR 138 7.21e-01 -0.017600 0.87700
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 237 6.47e-01 -0.017300 0.83800
RAS PROCESSING 23 8.87e-01 -0.017100 0.95600
FGFR2 MUTANT RECEPTOR ACTIVATION 26 8.84e-01 0.016600 0.95500
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX 16 9.09e-01 0.016400 0.96400
WNT5A DEPENDENT INTERNALIZATION OF FZD4 15 9.13e-01 -0.016300 0.96400
RHOG GTPASE CYCLE 73 8.11e-01 0.016200 0.92600
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 16 9.12e-01 -0.016000 0.96400
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 15 9.15e-01 -0.016000 0.96400
CILIUM ASSEMBLY 190 7.05e-01 0.016000 0.86800
ER TO GOLGI ANTEROGRADE TRANSPORT 140 7.46e-01 0.015900 0.89600
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA 16 9.13e-01 0.015800 0.96400
RAC2 GTPASE CYCLE 86 8.01e-01 0.015800 0.92100
SARS COV 1 INFECTION 48 8.53e-01 0.015400 0.94300
COLLAGEN CHAIN TRIMERIZATION 40 8.68e-01 -0.015200 0.94800
LAMININ INTERACTIONS 29 8.90e-01 -0.014800 0.95900
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE 27 8.95e-01 -0.014700 0.96000
INTERLEUKIN 1 SIGNALING 94 8.09e-01 0.014400 0.92600
CYTOPROTECTION BY HMOX1 120 7.86e-01 0.014400 0.91300
CYTOSOLIC TRNA AMINOACYLATION 24 9.03e-01 0.014400 0.96000
INCRETIN SYNTHESIS SECRETION AND INACTIVATION 12 9.32e-01 -0.014300 0.97100
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1 12 9.32e-01 -0.014300 0.97100
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION 85 8.21e-01 0.014200 0.93100
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS 59 8.51e-01 0.014200 0.94300
ACYL CHAIN REMODELLING OF PE 17 9.20e-01 0.014100 0.96700
DEGRADATION OF AXIN 53 8.60e-01 0.014000 0.94600
PI 3K CASCADE FGFR4 11 9.37e-01 -0.013800 0.97200
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 16 9.26e-01 -0.013400 0.97000
MITOTIC PROMETAPHASE 178 7.59e-01 -0.013300 0.90400
MITOPHAGY 29 9.01e-01 -0.013300 0.96000
GLUCOSE METABOLISM 80 8.38e-01 0.013300 0.93900
WNT LIGAND BIOGENESIS AND TRAFFICKING 23 9.13e-01 -0.013100 0.96400
DEGRADATION OF GLI1 BY THE PROTEASOME 57 8.65e-01 0.013000 0.94800
CELL JUNCTION ORGANIZATION 77 8.44e-01 0.013000 0.94100
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK 48 8.79e-01 -0.012700 0.95300
INTERLEUKIN 12 FAMILY SIGNALING 44 8.91e-01 -0.011900 0.95900
TRANSCRIPTIONAL REGULATION BY RUNX3 94 8.42e-01 0.011900 0.94100
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE 40 8.96e-01 0.011900 0.96000
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS 92 8.48e-01 0.011600 0.94300
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE 96 8.45e-01 0.011500 0.94100
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC 185 7.88e-01 -0.011500 0.91300
DEPOLYMERISATION OF THE NUCLEAR LAMINA 13 9.43e-01 -0.011400 0.97300
PRE NOTCH EXPRESSION AND PROCESSING 65 8.76e-01 -0.011200 0.95300
HEMOSTASIS 477 6.79e-01 0.011100 0.85900
PYROPTOSIS 21 9.30e-01 0.011100 0.97100
MRNA SPLICING 188 7.97e-01 0.010900 0.92000
ENDOGENOUS STEROLS 20 9.34e-01 -0.010700 0.97100
CELL CYCLE 596 6.59e-01 -0.010600 0.84500
TRANSFERRIN ENDOCYTOSIS AND RECYCLING 26 9.26e-01 -0.010600 0.97000
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS 33 9.17e-01 0.010400 0.96600
EGFR DOWNREGULATION 27 9.26e-01 -0.010400 0.97000
TRIGLYCERIDE METABOLISM 23 9.32e-01 -0.010300 0.97100
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 29 9.25e-01 0.010100 0.97000
METAL ION SLC TRANSPORTERS 24 9.33e-01 -0.009930 0.97100
FCERI MEDIATED NF KB ACTIVATION 76 8.83e-01 -0.009760 0.95500
EXTENSION OF TELOMERES 49 9.06e-01 0.009710 0.96300
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 169 8.31e-01 0.009530 0.93500
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS 28 9.32e-01 -0.009280 0.97100
POST TRANSLATIONAL PROTEIN MODIFICATION 1217 6.18e-01 -0.008570 0.82800
ABC TRANSPORTERS IN LIPID HOMEOSTASIS 13 9.58e-01 -0.008440 0.98200
RHOD GTPASE CYCLE 50 9.19e-01 -0.008280 0.96700
INTERLEUKIN 1 FAMILY SIGNALING 121 8.81e-01 0.007860 0.95500
METABOLISM OF LIPIDS 615 7.41e-01 0.007850 0.89100
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 11 9.64e-01 0.007780 0.98300
ACTIVATION OF BH3 ONLY PROTEINS 30 9.41e-01 0.007760 0.97200
ABC FAMILY PROTEINS MEDIATED TRANSPORT 93 8.98e-01 -0.007690 0.96000
CLEC7A DECTIN 1 SIGNALING 93 8.99e-01 0.007620 0.96000
THE NLRP3 INFLAMMASOME 15 9.61e-01 -0.007360 0.98200
CELL CYCLE MITOTIC 479 7.86e-01 -0.007270 0.91300
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 28 9.48e-01 0.007130 0.97700
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS 23 9.53e-01 -0.007110 0.98100
REGULATED NECROSIS 46 9.35e-01 -0.006920 0.97100
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS 25 9.54e-01 -0.006600 0.98100
MUSCLE CONTRACTION 159 8.98e-01 0.005910 0.96000
NUCLEAR ENVELOPE NE REASSEMBLY 63 9.36e-01 -0.005880 0.97100
INTRINSIC PATHWAY FOR APOPTOSIS 52 9.42e-01 0.005870 0.97200
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING 58 9.38e-01 0.005870 0.97200
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS 24 9.62e-01 -0.005580 0.98200
G2 M CHECKPOINTS 133 9.12e-01 0.005570 0.96400
HIV LIFE CYCLE 142 9.09e-01 0.005550 0.96400
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX 12 9.74e-01 -0.005470 0.98900
HIV INFECTION 218 8.93e-01 -0.005290 0.96000
TRANS GOLGI NETWORK VESICLE BUDDING 69 9.41e-01 -0.005130 0.97200
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES 10 9.79e-01 -0.004850 0.98900
M PHASE 343 8.84e-01 -0.004600 0.95500
TCR SIGNALING 99 9.39e-01 0.004430 0.97200
ACYL CHAIN REMODELLING OF PS 15 9.76e-01 -0.004400 0.98900
ERBB2 REGULATES CELL MOTILITY 13 9.79e-01 -0.004300 0.98900
RND2 GTPASE CYCLE 38 9.64e-01 0.004210 0.98300
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION 63 9.55e-01 -0.004120 0.98100
GOLGI ASSOCIATED VESICLE BIOGENESIS 54 9.58e-01 -0.004120 0.98200
GLUTAMATE AND GLUTAMINE METABOLISM 13 9.80e-01 -0.004000 0.98900
METABOLISM OF RNA 643 8.69e-01 0.003830 0.94800
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 76 9.54e-01 0.003820 0.98100
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI 24 9.74e-01 -0.003780 0.98900
HEDGEHOG LIGAND BIOGENESIS 61 9.61e-01 -0.003620 0.98200
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT 66 9.60e-01 -0.003600 0.98200
PLASMA LIPOPROTEIN CLEARANCE 26 9.75e-01 0.003490 0.98900
RHOF GTPASE CYCLE 40 9.71e-01 -0.003310 0.98800
ENOS ACTIVATION 11 9.88e-01 0.002670 0.99300
SURFACTANT METABOLISM 17 9.85e-01 -0.002640 0.99200
RNA POLYMERASE III TRANSCRIPTION 41 9.77e-01 -0.002630 0.98900
NEUTROPHIL DEGRANULATION 388 9.34e-01 -0.002460 0.97100
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 13 9.89e-01 0.002250 0.99300
MITOTIC G2 G2 M PHASES 184 9.61e-01 0.002120 0.98200
SPHINGOLIPID METABOLISM 80 9.76e-01 0.001910 0.98900
AUTOPHAGY 138 9.69e-01 0.001910 0.98700
G ALPHA S SIGNALLING EVENTS 98 9.83e-01 -0.001240 0.99100
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 120 9.83e-01 0.001140 0.99100
COPI MEDIATED ANTEROGRADE TRANSPORT 90 9.86e-01 -0.001060 0.99200
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS 11 9.96e-01 -0.000982 0.99700
MET ACTIVATES PTK2 SIGNALING 29 9.96e-01 -0.000548 0.99700
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES 61 9.94e-01 0.000525 0.99700
CELL EXTRACELLULAR MATRIX INTERACTIONS 18 9.97e-01 -0.000505 0.99700
GOLGI TO ER RETROGRADE TRANSPORT 119 9.94e-01 0.000431 0.99700


Detailed Gene set reports



ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
82
set ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
setSize 10
pANOVA 0.000287
s.dist -0.662
p.adjustANOVA 0.0151



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspa5 -9106
Xbp1 -9097
Ddit3 -9045
Calr -9044
Hsp90b1 -8902
Atf4 -7975
Nfya -6743
Nfyb -3792
Atf6 -2502
Nfyc 3753

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspa5 -9106
Xbp1 -9097
Ddit3 -9045
Calr -9044
Hsp90b1 -8902
Atf4 -7975
Nfya -6743
Nfyb -3792
Atf6 -2502
Nfyc 3753


ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K

ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K
299
set ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K
setSize 11
pANOVA 0.000264
s.dist -0.635
p.adjustANOVA 0.0151



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3r5 -8754
Gab1 -8584
Pik3ca -8013
Jak2 -7896
Lyn -7599
Pik3cd -7557
Epor -6149
Pik3cg -5866
Pik3cb -5533
Irs2 -1397
Pik3r1 1171

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3r5 -8754
Gab1 -8584
Pik3ca -8013
Jak2 -7896
Lyn -7599
Pik3cd -7557
Epor -6149
Pik3cg -5866
Pik3cb -5533
Irs2 -1397
Pik3r1 1171


FORMATION OF FIBRIN CLOT CLOTTING CASCADE

FORMATION OF FIBRIN CLOT CLOTTING CASCADE
330
set FORMATION OF FIBRIN CLOT CLOTTING CASCADE
setSize 19
pANOVA 2.49e-06
s.dist 0.624
p.adjustANOVA 0.00122



Top enriched genes

Top 20 genes
GeneID Gene Rank
F3 7824
F2r 7820
A2m 7807
Serping1 7494
Pros1 7133
F8 7087
Gp5 6795
C1qbp 6505
Tfpi 6002
Vwf 5862
Serpine2 4803
Prtn3 4378
F5 3717
Thbd 3602
Serpind1 3476
Gp1ba 3023
Serpinc1 2244
F13a1 1780
Prcp -9023

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F3 7824
F2r 7820
A2m 7807
Serping1 7494
Pros1 7133
F8 7087
Gp5 6795
C1qbp 6505
Tfpi 6002
Vwf 5862
Serpine2 4803
Prtn3 4378
F5 3717
Thbd 3602
Serpind1 3476
Gp1ba 3023
Serpinc1 2244
F13a1 1780
Prcp -9023


COMMON PATHWAY OF FIBRIN CLOT FORMATION

COMMON PATHWAY OF FIBRIN CLOT FORMATION
169
set COMMON PATHWAY OF FIBRIN CLOT FORMATION
setSize 10
pANOVA 0.00071
s.dist 0.618
p.adjustANOVA 0.0252



Top enriched genes

Top 20 genes
GeneID Gene Rank
F2r 7820
Pros1 7133
F8 7087
Serpine2 4803
Prtn3 4378
F5 3717
Thbd 3602
Serpind1 3476
Serpinc1 2244
F13a1 1780

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
F2r 7820
Pros1 7133
F8 7087
Serpine2 4803
Prtn3 4378
F5 3717
Thbd 3602
Serpind1 3476
Serpinc1 2244
F13a1 1780


INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION

INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION
490
set INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION
setSize 12
pANOVA 0.000332
s.dist 0.598
p.adjustANOVA 0.0156



Top enriched genes

Top 20 genes
GeneID Gene Rank
A2m 7807
Serping1 7494
Pros1 7133
F8 7087
Gp5 6795
C1qbp 6505
Vwf 5862
Serpine2 4803
Serpind1 3476
Gp1ba 3023
Serpinc1 2244
Prcp -9023

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
A2m 7807
Serping1 7494
Pros1 7133
F8 7087
Gp5 6795
C1qbp 6505
Vwf 5862
Serpine2 4803
Serpind1 3476
Gp1ba 3023
Serpinc1 2244
Prcp -9023


BIOTIN TRANSPORT AND METABOLISM

BIOTIN TRANSPORT AND METABOLISM
101
set BIOTIN TRANSPORT AND METABOLISM
setSize 11
pANOVA 0.0016
s.dist 0.549
p.adjustANOVA 0.0408



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mccc2 7514
Pccb 7216
Hlcs 7120
Acacb 6630
Slc5a6 5683
Pcx 5621
Btd 4865
Pcca 2385
Mccc1 1693
Pdzd11 1614
Acaca -6112

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mccc2 7514
Pccb 7216
Hlcs 7120
Acacb 6630
Slc5a6 5683
Pcx 5621
Btd 4865
Pcca 2385
Mccc1 1693
Pdzd11 1614
Acaca -6112


AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS

AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS
45
set AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS
setSize 10
pANOVA 0.00874
s.dist -0.479
p.adjustANOVA 0.112



Top enriched genes

Top 20 genes
GeneID Gene Rank
Creb1 -8839
Akt2 -8711
Nr4a1 -8436
Akt3 -6179
Rps6kb2 -5991
Foxo4 -4967
Foxo1 -2069
Foxo3 -1534
Foxo6 -473
Akt1 280

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Creb1 -8839
Akt2 -8711
Nr4a1 -8436
Akt3 -6179
Rps6kb2 -5991
Foxo4 -4967
Foxo1 -2069
Foxo3 -1534
Foxo6 -473
Akt1 280


ATTENUATION PHASE

ATTENUATION PHASE
84
set ATTENUATION PHASE
setSize 24
pANOVA 8.72e-05
s.dist -0.463
p.adjustANOVA 0.00731



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspb1 -9078
Serpinh1 -9056
Dnajb1 -9015
Hsph1 -9009
Hspa1b -8929
Fkbp4 -8926
Hspa8 -8841
Hsp90aa1 -8747
Hspa1a -8354
Ptges3 -8288
Hsp90ab1 -7515
Dedd2 -7215
Crebbp -6906
Tnfrsf21 -6854
Ep300 -3538
Hsf1 -2790
Cryba4 -2236
Mrpl18 -1627
Hspa2 -566
Dnajb6 1427

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspb1 -9078
Serpinh1 -9056
Dnajb1 -9015
Hsph1 -9009
Hspa1b -8929
Fkbp4 -8926
Hspa8 -8841
Hsp90aa1 -8747
Hspa1a -8354
Ptges3 -8288
Hsp90ab1 -7515
Dedd2 -7215
Crebbp -6906
Tnfrsf21 -6854
Ep300 -3538
Hsf1 -2790
Cryba4 -2236
Mrpl18 -1627
Hspa2 -566
Dnajb6 1427
Col4a6 1854
Ubb 3907
Hsbp1 4807
Hspa1l 6260


LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME

LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME
521
set LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME
setSize 13
pANOVA 0.00425
s.dist -0.458
p.adjustANOVA 0.0745



Top enriched genes

Top 20 genes
GeneID Gene Rank
Bdnf -8972
Gps2 -7695
Tbl1x -6921
Calm1 -6088
Camk4 -6010
Tbl1xr1 -5356
Ncor1 -5255
Mecp2 -5028
Sin3a -4327
Ncor2 -3759
Hdac3 -2903
Hdac1 876
Prkaca 2759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Bdnf -8972
Gps2 -7695
Tbl1x -6921
Calm1 -6088
Camk4 -6010
Tbl1xr1 -5356
Ncor1 -5255
Mecp2 -5028
Sin3a -4327
Ncor2 -3759
Hdac3 -2903
Hdac1 876
Prkaca 2759


PURINE CATABOLISM

PURINE CATABOLISM
757
set PURINE CATABOLISM
setSize 16
pANOVA 0.00169
s.dist 0.453
p.adjustANOVA 0.0416



Top enriched genes

Top 20 genes
GeneID Gene Rank
Xdh 7727
Nudt1 7672
Nudt16 7477
Nudt9 7452
Nudt15 7324
Nt5c 7081
Dnph1 6968
Nt5e 5797
Nt5c2 5669
Itpa 1733
Pnp2 1058
Nt5c1a 1052
Nudt18 -161
Gda -2811
Nudt5 -4317
Adprm -8429

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Xdh 7727
Nudt1 7672
Nudt16 7477
Nudt9 7452
Nudt15 7324
Nt5c 7081
Dnph1 6968
Nt5e 5797
Nt5c2 5669
Itpa 1733
Pnp2 1058
Nt5c1a 1052
Nudt18 -161
Gda -2811
Nudt5 -4317
Adprm -8429


P38MAPK EVENTS

P38MAPK EVENTS
676
set P38MAPK EVENTS
setSize 12
pANOVA 0.00681
s.dist -0.451
p.adjustANOVA 0.094



Top enriched genes

Top 20 genes
GeneID Gene Rank
Mapk12 -8422
Mapk11 -8342
Nras -8330
Ralb -7441
Rala -6774
Kras -5974
Mapkapk3 -5823
Mapk14 -5719
Src -2599
Hras 593
Ralgds 2018
Mapkapk2 3335

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Mapk12 -8422
Mapk11 -8342
Nras -8330
Ralb -7441
Rala -6774
Kras -5974
Mapkapk3 -5823
Mapk14 -5719
Src -2599
Hras 593
Ralgds 2018
Mapkapk2 3335


TRAF6 MEDIATED IRF7 ACTIVATION

TRAF6 MEDIATED IRF7 ACTIVATION
1098
set TRAF6 MEDIATED IRF7 ACTIVATION
setSize 15
pANOVA 0.00262
s.dist -0.449
p.adjustANOVA 0.0543



Top enriched genes

Top 20 genes
GeneID Gene Rank
Irf7 -9041
Ddx58 -8458
Traf6 -8423
Traf2 -7206
Crebbp -6906
Sike1 -6348
Tank -6171
Irf3 -5666
Ikbke -5263
Trim25 -4525
Ep300 -3538
Ifih1 -2922
Mavs -1124
Tbk1 3219
Rnf135 5837

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf7 -9041
Ddx58 -8458
Traf6 -8423
Traf2 -7206
Crebbp -6906
Sike1 -6348
Tank -6171
Irf3 -5666
Ikbke -5263
Trim25 -4525
Ep300 -3538
Ifih1 -2922
Mavs -1124
Tbk1 3219
Rnf135 5837


SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION

SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
913
set SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION
setSize 14
pANOVA 0.00439
s.dist -0.44
p.adjustANOVA 0.0746



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tln1 -8767
Fes -8433
Rnd1 -7502
Pip5k1c -6913
Sema3a -5760
Plxna4 -5216
Plxna3 -5093
Plxna2 -4829
Rras -4790
Nrp1 -4424
Plxna1 -3551
Rac1 -2608
Fyn 2255
Farp2 4594

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tln1 -8767
Fes -8433
Rnd1 -7502
Pip5k1c -6913
Sema3a -5760
Plxna4 -5216
Plxna3 -5093
Plxna2 -4829
Rras -4790
Nrp1 -4424
Plxna1 -3551
Rac1 -2608
Fyn 2255
Farp2 4594


ERYTHROPOIETIN ACTIVATES RAS

ERYTHROPOIETIN ACTIVATES RAS
300
set ERYTHROPOIETIN ACTIVATES RAS
setSize 13
pANOVA 0.00639
s.dist -0.437
p.adjustANOVA 0.0892



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nras -8330
Jak2 -7896
Lyn -7599
Epor -6149
Kras -5974
Crkl -5885
Vav1 -5708
Sos1 -5137
Rapgef1 -2981
Irs2 -1397
Shc1 -268
Grb2 373
Hras 593

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nras -8330
Jak2 -7896
Lyn -7599
Epor -6149
Kras -5974
Crkl -5885
Vav1 -5708
Sos1 -5137
Rapgef1 -2981
Irs2 -1397
Shc1 -268
Grb2 373
Hras 593


REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
817
set REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize 17
pANOVA 0.00219
s.dist -0.429
p.adjustANOVA 0.0484



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ccnd1 -9063
Cbfb -8799
Ago3 -8593
Cdk6 -8270
Tnrc6b -7781
Ago2 -7704
Ago4 -6947
Ccnd2 -6393
Pml -6276
Mov10 -5114
Runx1 -3172
Src -2599
Tnrc6a 21
Ccnd3 412
Ago1 2169
Tnrc6c 2469
Ptpn11 3062

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ccnd1 -9063
Cbfb -8799
Ago3 -8593
Cdk6 -8270
Tnrc6b -7781
Ago2 -7704
Ago4 -6947
Ccnd2 -6393
Pml -6276
Mov10 -5114
Runx1 -3172
Src -2599
Tnrc6a 21
Ccnd3 412
Ago1 2169
Tnrc6c 2469
Ptpn11 3062


SIGNALING BY FGFR4 IN DISEASE

SIGNALING BY FGFR4 IN DISEASE
956
set SIGNALING BY FGFR4 IN DISEASE
setSize 10
pANOVA 0.0188
s.dist -0.429
p.adjustANOVA 0.169



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gab1 -8584
Nras -8330
Pik3ca -8013
Kras -5974
Sos1 -5137
Frs2 -5034
Plcg1 -3767
Grb2 373
Hras 593
Pik3r1 1171

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gab1 -8584
Nras -8330
Pik3ca -8013
Kras -5974
Sos1 -5137
Frs2 -5034
Plcg1 -3767
Grb2 373
Hras 593
Pik3r1 1171


MET ACTIVATES RAP1 AND RAC1

MET ACTIVATES RAP1 AND RAC1
539
set MET ACTIVATES RAP1 AND RAC1
setSize 11
pANOVA 0.0139
s.dist -0.428
p.adjustANOVA 0.147



Top enriched genes

Top 20 genes
GeneID Gene Rank
Gab1 -8584
Rap1a -8221
Met -7240
Hgf -6642
Crkl -5885
Rap1b -5343
Crk -3639
Rapgef1 -2981
Rac1 -2608
Grb2 373
Dock7 3885

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Gab1 -8584
Rap1a -8221
Met -7240
Hgf -6642
Crkl -5885
Rap1b -5343
Crk -3639
Rapgef1 -2981
Rac1 -2608
Grb2 373
Dock7 3885


MUCOPOLYSACCHARIDOSES

MUCOPOLYSACCHARIDOSES
590
set MUCOPOLYSACCHARIDOSES
setSize 11
pANOVA 0.0142
s.dist 0.427
p.adjustANOVA 0.148



Top enriched genes

Top 20 genes
GeneID Gene Rank
Sgsh 7432
Glb1 6888
Hyal1 6685
Arsb 5456
Gns 5182
Galns 4046
Hgsnat 3042
Gusb 1292
Naglu 883
Ids -1735
Idua -6363

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Sgsh 7432
Glb1 6888
Hyal1 6685
Arsb 5456
Gns 5182
Galns 4046
Hgsnat 3042
Gusb 1292
Naglu 883
Ids -1735
Idua -6363


CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE

CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
187
set CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE
setSize 11
pANOVA 0.02
s.dist -0.405
p.adjustANOVA 0.177



Top enriched genes

Top 20 genes
GeneID Gene Rank
Creb1 -8839
Adcy1 -6202
Calm1 -6088
Prkacb -5917
Prkar2b -5890
Prkx -4782
Prkar2a -4612
Prkar1b -3627
Prkar1a -1916
Adcy8 371
Prkaca 2759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Creb1 -8839
Adcy1 -6202
Calm1 -6088
Prkacb -5917
Prkar2b -5890
Prkx -4782
Prkar2a -4612
Prkar1b -3627
Prkar1a -1916
Adcy8 371
Prkaca 2759


ATF6 ATF6 ALPHA ACTIVATES CHAPERONES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONES
83
set ATF6 ATF6 ALPHA ACTIVATES CHAPERONES
setSize 12
pANOVA 0.0153
s.dist -0.404
p.adjustANOVA 0.155



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspa5 -9106
Xbp1 -9097
Ddit3 -9045
Calr -9044
Hsp90b1 -8902
Atf4 -7975
Nfya -6743
Nfyb -3792
Atf6 -2502
Nfyc 3753
Mbtps2 5980
Mbtps1 7759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspa5 -9106
Xbp1 -9097
Ddit3 -9045
Calr -9044
Hsp90b1 -8902
Atf4 -7975
Nfya -6743
Nfyb -3792
Atf6 -2502
Nfyc 3753
Mbtps2 5980
Mbtps1 7759


SEMA3A PAK DEPENDENT AXON REPULSION

SEMA3A PAK DEPENDENT AXON REPULSION
912
set SEMA3A PAK DEPENDENT AXON REPULSION
setSize 16
pANOVA 0.00534
s.dist -0.402
p.adjustANOVA 0.0834



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsp90aa1 -8747
Fes -8433
Hsp90ab1 -7515
Pak1 -6645
Sema3a -5760
Plxna4 -5216
Plxna3 -5093
Plxna2 -4829
Nrp1 -4424
Plxna1 -3551
Pak3 -3417
Rac1 -2608
Pak2 -1312
Limk1 253
Cfl1 376
Fyn 2255

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsp90aa1 -8747
Fes -8433
Hsp90ab1 -7515
Pak1 -6645
Sema3a -5760
Plxna4 -5216
Plxna3 -5093
Plxna2 -4829
Nrp1 -4424
Plxna1 -3551
Pak3 -3417
Rac1 -2608
Pak2 -1312
Limk1 253
Cfl1 376
Fyn 2255


TRAF3 DEPENDENT IRF ACTIVATION PATHWAY

TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
1096
set TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
setSize 13
pANOVA 0.0121
s.dist -0.402
p.adjustANOVA 0.136



Top enriched genes

Top 20 genes
GeneID Gene Rank
Irf7 -9041
Ddx58 -8458
Traf3 -7759
Crebbp -6906
Sike1 -6348
Irf3 -5666
Ikbke -5263
Trim25 -4525
Ep300 -3538
Ifih1 -2922
Mavs -1124
Tbk1 3219
Rnf135 5837

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Irf7 -9041
Ddx58 -8458
Traf3 -7759
Crebbp -6906
Sike1 -6348
Irf3 -5666
Ikbke -5263
Trim25 -4525
Ep300 -3538
Ifih1 -2922
Mavs -1124
Tbk1 3219
Rnf135 5837


HSF1 ACTIVATION

HSF1 ACTIVATION
431
set HSF1 ACTIVATION
setSize 26
pANOVA 0.000544
s.dist -0.392
p.adjustANOVA 0.0227



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hspb1 -9078
Serpinh1 -9056
Dnajb1 -9015
Hsph1 -9009
Hspa1b -8929
Fkbp4 -8926
Hsp90aa1 -8747
Hspa1a -8354
Ptges3 -8288
Hsp90ab1 -7515
Dedd2 -7215
Tnfrsf21 -6854
Hdac6 -5561
Rpa3 -5289
Vcp -4958
Hsf1 -2790
Cryba4 -2236
Mrpl18 -1627
Rpa1 145
Dnajb6 1427

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hspb1 -9078
Serpinh1 -9056
Dnajb1 -9015
Hsph1 -9009
Hspa1b -8929
Fkbp4 -8926
Hsp90aa1 -8747
Hspa1a -8354
Ptges3 -8288
Hsp90ab1 -7515
Dedd2 -7215
Tnfrsf21 -6854
Hdac6 -5561
Rpa3 -5289
Vcp -4958
Hsf1 -2790
Cryba4 -2236
Mrpl18 -1627
Rpa1 145
Dnajb6 1427
Col4a6 1854
Ywhae 2020
Eef1a1 2455
Ubb 3907
Rpa2 4095
Hsbp1 4807


MITOCHONDRIAL FATTY ACID BETA OXIDATION

MITOCHONDRIAL FATTY ACID BETA OXIDATION
569
set MITOCHONDRIAL FATTY ACID BETA OXIDATION
setSize 33
pANOVA 0.000102
s.dist 0.391
p.adjustANOVA 0.00753



Top enriched genes

Top 20 genes
GeneID Gene Rank
Acaa2 7502
Acadl 7330
Acot9 7257
Pccb 7216
Echs1 7001
Acad11 6872
Mmut 6862
Dbi 6761
Acot11 6724
Acot1 6353
Acadm 6015
Acads 5957
Hadh 5214
Mcat 4555
Acbd6 4503
Acsf2 4435
Hadhb 4346
Acot3 3866
Hadha 3488
Acot2 3263

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Acaa2 7502
Acadl 7330
Acot9 7257
Pccb 7216
Echs1 7001
Acad11 6872
Mmut 6862
Dbi 6761
Acot11 6724
Acot1 6353
Acadm 6015
Acads 5957
Hadh 5214
Mcat 4555
Acbd6 4503
Acsf2 4435
Hadhb 4346
Acot3 3866
Hadha 3488
Acot2 3263
Mcee 2514
Pcca 2385
Acot7 1890
Eci1 1782
Acot13 387
Acadvl 2
Decr1 -577
Ndufab1 -1865
Mmaa -6137
Acad10 -6538
Mecr -6593
Pctp -6794
Them4 -7789


SIGNALING BY ERYTHROPOIETIN

SIGNALING BY ERYTHROPOIETIN
945
set SIGNALING BY ERYTHROPOIETIN
setSize 24
pANOVA 0.00103
s.dist -0.387
p.adjustANOVA 0.0317



Top enriched genes

Top 20 genes
GeneID Gene Rank
Pik3r5 -8754
Gab1 -8584
Nras -8330
Pik3ca -8013
Jak2 -7896
Lyn -7599
Pik3cd -7557
Epor -6149
Kras -5974
Crkl -5885
Pik3cg -5866
Vav1 -5708
Pik3cb -5533
Sos1 -5137
Plcg1 -3767
Rapgef1 -2981
Stat5b -2741
Irs2 -1397
Shc1 -268
Grb2 373

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Pik3r5 -8754
Gab1 -8584
Nras -8330
Pik3ca -8013
Jak2 -7896
Lyn -7599
Pik3cd -7557
Epor -6149
Kras -5974
Crkl -5885
Pik3cg -5866
Vav1 -5708
Pik3cb -5533
Sos1 -5137
Plcg1 -3767
Rapgef1 -2981
Stat5b -2741
Irs2 -1397
Shc1 -268
Grb2 373
Hras 593
Pik3r1 1171
Stat5a 5779
Plcg2 6338


PKA MEDIATED PHOSPHORYLATION OF CREB

PKA MEDIATED PHOSPHORYLATION OF CREB
710
set PKA MEDIATED PHOSPHORYLATION OF CREB
setSize 19
pANOVA 0.00353
s.dist -0.387
p.adjustANOVA 0.0646



Top enriched genes

Top 20 genes
GeneID Gene Rank
Creb1 -8839
Adcy3 -8466
Adcy4 -7397
Adcy2 -6692
Adcy1 -6202
Calm1 -6088
Prkacb -5917
Prkar2b -5890
Prkx -4782
Prkar2a -4612
Nbea -4490
Prkar1b -3627
Adcy9 -3451
Adcy6 -2526
Prkar1a -1916
Adcy8 371
Adcy5 1393
Adcy7 2102
Prkaca 2759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Creb1 -8839
Adcy3 -8466
Adcy4 -7397
Adcy2 -6692
Adcy1 -6202
Calm1 -6088
Prkacb -5917
Prkar2b -5890
Prkx -4782
Prkar2a -4612
Nbea -4490
Prkar1b -3627
Adcy9 -3451
Adcy6 -2526
Prkar1a -1916
Adcy8 371
Adcy5 1393
Adcy7 2102
Prkaca 2759


RHOBTB2 GTPASE CYCLE

RHOBTB2 GTPASE CYCLE
860
set RHOBTB2 GTPASE CYCLE
setSize 23
pANOVA 0.00137
s.dist -0.386
p.adjustANOVA 0.0366



Top enriched genes

Top 20 genes
GeneID Gene Rank
Rhobtb2 -8953
Phip -8875
Hsp90aa1 -8747
Cct7 -8583
Actn1 -8032
Stk38 -7531
Hsp90ab1 -7515
Cct2 -6559
Tra2b -6528
Tmod3 -6033
Dbn1 -5305
Cct6a -5252
Myo6 -5143
Ddx39b -3691
Actg1 -3471
Hnrnpc -3354
Srrm1 -966
Rbmx 185
Txnl1 1498
Msi2 2730

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Rhobtb2 -8953
Phip -8875
Hsp90aa1 -8747
Cct7 -8583
Actn1 -8032
Stk38 -7531
Hsp90ab1 -7515
Cct2 -6559
Tra2b -6528
Tmod3 -6033
Dbn1 -5305
Cct6a -5252
Myo6 -5143
Ddx39b -3691
Actg1 -3471
Hnrnpc -3354
Srrm1 -966
Rbmx 185
Txnl1 1498
Msi2 2730
Twf1 3282
Cul3 3457
Cdc37 3721


MET ACTIVATES RAS SIGNALING

MET ACTIVATES RAS SIGNALING
540
set MET ACTIVATES RAS SIGNALING
setSize 10
pANOVA 0.0369
s.dist -0.381
p.adjustANOVA 0.244



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nras -8330
Ranbp10 -7269
Met -7240
Hgf -6642
Kras -5974
Sos1 -5137
Shc1 -268
Grb2 373
Hras 593
Ranbp9 1248

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nras -8330
Ranbp10 -7269
Met -7240
Hgf -6642
Kras -5974
Sos1 -5137
Shc1 -268
Grb2 373
Hras 593
Ranbp9 1248


INTERLEUKIN 27 SIGNALING

INTERLEUKIN 27 SIGNALING
476
set INTERLEUKIN 27 SIGNALING
setSize 10
pANOVA 0.0416
s.dist -0.372
p.adjustANOVA 0.254



Top enriched genes

Top 20 genes
GeneID Gene Rank
Stat1 -8227
Jak2 -7896
Ebi3 -7256
Tyk2 -5608
Canx -5301
Crlf1 -3949
Il6st -3203
Stat3 82
Jak1 249
Il27ra 3236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Stat1 -8227
Jak2 -7896
Ebi3 -7256
Tyk2 -5608
Canx -5301
Crlf1 -3949
Il6st -3203
Stat3 82
Jak1 249
Il27ra 3236


ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS

ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
27
set ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
setSize 10
pANOVA 0.043
s.dist -0.37
p.adjustANOVA 0.259



Top enriched genes

Top 20 genes
GeneID Gene Rank
Fos -9059
Mapk11 -8342
Mapk8 -6120
Mapk14 -5719
Jun -5333
Mapk10 -3657
Atf2 -2161
Mapk9 -905
Mapk1 329
Mapk3 3305

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Fos -9059
Mapk11 -8342
Mapk8 -6120
Mapk14 -5719
Jun -5333
Mapk10 -3657
Atf2 -2161
Mapk9 -905
Mapk1 329
Mapk3 3305


CONSTITUTIVE SIGNALING BY EGFRVIII

CONSTITUTIVE SIGNALING BY EGFRVIII
175
set CONSTITUTIVE SIGNALING BY EGFRVIII
setSize 15
pANOVA 0.0134
s.dist -0.369
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsp90aa1 -8747
Gab1 -8584
Nras -8330
Cbl -8147
Pik3ca -8013
Kras -5974
Egf -5442
Sos1 -5137
Plcg1 -3767
Shc1 -268
Egfr 189
Grb2 373
Hras 593
Pik3r1 1171
Cdc37 3721

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsp90aa1 -8747
Gab1 -8584
Nras -8330
Cbl -8147
Pik3ca -8013
Kras -5974
Egf -5442
Sos1 -5137
Plcg1 -3767
Shc1 -268
Egfr 189
Grb2 373
Hras 593
Pik3r1 1171
Cdc37 3721


INTERLEUKIN 35 SIGNALLING

INTERLEUKIN 35 SIGNALLING
478
set INTERLEUKIN 35 SIGNALLING
setSize 10
pANOVA 0.0491
s.dist -0.359
p.adjustANOVA 0.264



Top enriched genes

Top 20 genes
GeneID Gene Rank
Stat1 -8227
Jak2 -7896
Ebi3 -7256
Tyk2 -5608
Canx -5301
Il6st -3203
Il12a -2865
Stat3 82
Jak1 249
Il27ra 3236

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Stat1 -8227
Jak2 -7896
Ebi3 -7256
Tyk2 -5608
Canx -5301
Il6st -3203
Il12a -2865
Stat3 82
Jak1 249
Il27ra 3236


EPHRIN SIGNALING

EPHRIN SIGNALING
290
set EPHRIN SIGNALING
setSize 19
pANOVA 0.00692
s.dist -0.358
p.adjustANOVA 0.0944



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ephb3 -9070
Arhgef7 -8541
Efnb2 -8225
Pak1 -6645
Ephb1 -6438
Ephb6 -5257
Git1 -4263
Ephb4 -4200
Pak3 -3417
Sdcbp -2816
Rac1 -2608
Src -2599
Efnb1 -2556
Ephb2 -2178
Nck2 -2057
Pak2 -1312
Efnb3 -1001
Myl12a 1289
Fyn 2255

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ephb3 -9070
Arhgef7 -8541
Efnb2 -8225
Pak1 -6645
Ephb1 -6438
Ephb6 -5257
Git1 -4263
Ephb4 -4200
Pak3 -3417
Sdcbp -2816
Rac1 -2608
Src -2599
Efnb1 -2556
Ephb2 -2178
Nck2 -2057
Pak2 -1312
Efnb3 -1001
Myl12a 1289
Fyn 2255


METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS

METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS
545
set METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS
setSize 10
pANOVA 0.0524
s.dist 0.354
p.adjustANOVA 0.273



Top enriched genes

Top 20 genes
GeneID Gene Rank
Agt 7754
Ace 6608
Ctsd 5001
Ctsz 3370
Enpep 3148
Anpep 1740
Ace2 1208
Atp6ap2 457
Mme -1631
Aopep -3987

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Agt 7754
Ace 6608
Ctsd 5001
Ctsz 3370
Enpep 3148
Anpep 1740
Ace2 1208
Atp6ap2 457
Mme -1631
Aopep -3987


NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION

NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION
611
set NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION
setSize 21
pANOVA 0.00551
s.dist -0.35
p.adjustANOVA 0.0834



Top enriched genes

Top 20 genes
GeneID Gene Rank
Grin2a -7764
Lrrc7 -7139
Dlg4 -6875
Grin2b -6798
Actn2 -6716
Dlg1 -6542
Dlg3 -6389
Ppm1f -6175
Calm1 -6088
Camk4 -6010
Camk1 -5655
Dlg2 -4965
Camk2a -4371
Grin1 -3658
Nefl -1421
Ppm1e -1341
Camk2g -806
Camk2b -692
Grin2c 2617
Grin2d 5159

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grin2a -7764
Lrrc7 -7139
Dlg4 -6875
Grin2b -6798
Actn2 -6716
Dlg1 -6542
Dlg3 -6389
Ppm1f -6175
Calm1 -6088
Camk4 -6010
Camk1 -5655
Dlg2 -4965
Camk2a -4371
Grin1 -3658
Nefl -1421
Ppm1e -1341
Camk2g -806
Camk2b -692
Grin2c 2617
Grin2d 5159
Camk2d 6087


REGULATION OF MECP2 EXPRESSION AND ACTIVITY

REGULATION OF MECP2 EXPRESSION AND ACTIVITY
810
set REGULATION OF MECP2 EXPRESSION AND ACTIVITY
setSize 30
pANOVA 0.000954
s.dist -0.349
p.adjustANOVA 0.0305



Top enriched genes

Top 20 genes
GeneID Gene Rank
Creb1 -8839
Ago3 -8593
Tnrc6b -7781
Ago2 -7704
Gps2 -7695
Ago4 -6947
Tbl1x -6921
Calm1 -6088
Foxg1 -6076
Camk4 -6010
Tbl1xr1 -5356
Htt -5284
Ncor1 -5255
Mov10 -5114
Mecp2 -5028
Hipk2 -4466
Camk2a -4371
Sin3a -4327
Ncor2 -3759
Hdac2 -3617

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Creb1 -8839
Ago3 -8593
Tnrc6b -7781
Ago2 -7704
Gps2 -7695
Ago4 -6947
Tbl1x -6921
Calm1 -6088
Foxg1 -6076
Camk4 -6010
Tbl1xr1 -5356
Htt -5284
Ncor1 -5255
Mov10 -5114
Mecp2 -5028
Hipk2 -4466
Camk2a -4371
Sin3a -4327
Ncor2 -3759
Hdac2 -3617
Hdac3 -2903
Camk2g -806
Camk2b -692
Tnrc6a 21
Hdac1 876
Lbr 1730
Ago1 2169
Tnrc6c 2469
Prkaca 2759
Camk2d 6087


ANTIMICROBIAL PEPTIDES

ANTIMICROBIAL PEPTIDES
59
set ANTIMICROBIAL PEPTIDES
setSize 15
pANOVA 0.0219
s.dist 0.342
p.adjustANOVA 0.184



Top enriched genes

Top 20 genes
GeneID Gene Rank
S100a9 7607
Lyz2 7349
Defb1 6823
Chga 5832
Prtn3 4378
Pglyrp1 4053
Atox1 3867
Clu 2475
Slc11a1 2123
Pdzd11 1614
Tlr2 -736
Defb42 -793
Tlr1 -996
Lcn2 -4617
Atp7a -5080

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
S100a9 7607
Lyz2 7349
Defb1 6823
Chga 5832
Prtn3 4378
Pglyrp1 4053
Atox1 3867
Clu 2475
Slc11a1 2123
Pdzd11 1614
Tlr2 -736
Defb42 -793
Tlr1 -996
Lcn2 -4617
Atp7a -5080


IONOTROPIC ACTIVITY OF KAINATE RECEPTORS

IONOTROPIC ACTIVITY OF KAINATE RECEPTORS
495
set IONOTROPIC ACTIVITY OF KAINATE RECEPTORS
setSize 10
pANOVA 0.0619
s.dist -0.341
p.adjustANOVA 0.298



Top enriched genes

Top 20 genes
GeneID Gene Rank
Grik2 -7255
Grik5 -7254
Dlg4 -6875
Dlg1 -6542
Dlg3 -6389
Calm1 -6088
Grik3 -2135
Ncald -224
Grik4 90
Grik1 7440

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Grik2 -7255
Grik5 -7254
Dlg4 -6875
Dlg1 -6542
Dlg3 -6389
Calm1 -6088
Grik3 -2135
Ncald -224
Grik4 90
Grik1 7440


PLASMA LIPOPROTEIN ASSEMBLY

PLASMA LIPOPROTEIN ASSEMBLY
712
set PLASMA LIPOPROTEIN ASSEMBLY
setSize 11
pANOVA 0.0517
s.dist 0.339
p.adjustANOVA 0.271



Top enriched genes

Top 20 genes
GeneID Gene Rank
A2m 7807
Abca1 7357
Apoe 6190
Mttp 4599
Sar1b 3196
Prkaca 2759
Apoc1 2383
Zdhhc8 1772
P4hb 406
Prkacb -5917
Bmp1 -5954

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
A2m 7807
Abca1 7357
Apoe 6190
Mttp 4599
Sar1b 3196
Prkaca 2759
Apoc1 2383
Zdhhc8 1772
P4hb 406
Prkacb -5917
Bmp1 -5954


GP1B IX V ACTIVATION SIGNALLING

GP1B IX V ACTIVATION SIGNALLING
398
set GP1B IX V ACTIVATION SIGNALLING
setSize 10
pANOVA 0.0652
s.dist 0.337
p.adjustANOVA 0.307



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col1a2 7774
Col1a1 7347
Gp5 6795
Vwf 5862
Gp1ba 3023
Pik3r1 1171
Raf1 -1126
Ywhaz -1970
Src -2599
Flna -4088

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col1a2 7774
Col1a1 7347
Gp5 6795
Vwf 5862
Gp1ba 3023
Pik3r1 1171
Raf1 -1126
Ywhaz -1970
Src -2599
Flna -4088


NUCLEOBASE CATABOLISM

NUCLEOBASE CATABOLISM
657
set NUCLEOBASE CATABOLISM
setSize 31
pANOVA 0.00119
s.dist 0.336
p.adjustANOVA 0.0339



Top enriched genes

Top 20 genes
GeneID Gene Rank
Xdh 7727
Nudt1 7672
Nudt16 7477
Nudt9 7452
Entpd3 7433
Nudt15 7324
Nt5c 7081
Dnph1 6968
Entpd4 5871
Nt5e 5797
Nt5c2 5669
Entpd5 5520
Nt5c3 4708
Nt5m 3920
Upb1 3129
Tymp 3045
Entpd2 2914
Itpa 1733
Pnp2 1058
Nt5c1a 1052

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Xdh 7727
Nudt1 7672
Nudt16 7477
Nudt9 7452
Entpd3 7433
Nudt15 7324
Nt5c 7081
Dnph1 6968
Entpd4 5871
Nt5e 5797
Nt5c2 5669
Entpd5 5520
Nt5c3 4708
Nt5m 3920
Upb1 3129
Tymp 3045
Entpd2 2914
Itpa 1733
Pnp2 1058
Nt5c1a 1052
Entpd6 798
Upp2 219
Samhd1 -105
Nudt18 -161
Dpyd -2174
Gda -2811
Nudt5 -4317
Entpd7 -4725
Entpd1 -5713
Upp1 -7532
Adprm -8429


INSULIN PROCESSING

INSULIN PROCESSING
454
set INSULIN PROCESSING
setSize 24
pANOVA 0.00439
s.dist -0.336
p.adjustANOVA 0.0746



Top enriched genes

Top 20 genes
GeneID Gene Rank
Ero1b -8070
Stx1a -8025
Ero1a -7886
Kif5c -7064
Pcsk1 -6590
Slc30a5 -6551
Exoc3 -5285
Exoc1 -4979
Vamp2 -4832
Kif5b -4707
Myrip -4625
Exoc8 -4238
Exoc6 -3883
Exoc5 -3856
Myo5a -3605
Kif5a -2914
Pcsk2 -2908
Exoc4 -2234
Exoc7 -1402
Slc30a7 -717

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Ero1b -8070
Stx1a -8025
Ero1a -7886
Kif5c -7064
Pcsk1 -6590
Slc30a5 -6551
Exoc3 -5285
Exoc1 -4979
Vamp2 -4832
Kif5b -4707
Myrip -4625
Exoc8 -4238
Exoc6 -3883
Exoc5 -3856
Myo5a -3605
Kif5a -2914
Pcsk2 -2908
Exoc4 -2234
Exoc7 -1402
Slc30a7 -717
Rab27a -249
Slc30a6 2060
Cpe 2147
Exoc2 6926


SIGNALING BY KIT IN DISEASE

SIGNALING BY KIT IN DISEASE
964
set SIGNALING BY KIT IN DISEASE
setSize 20
pANOVA 0.00973
s.dist -0.334
p.adjustANOVA 0.116



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nras -8330
Stat1 -8227
Pik3ca -8013
Jak2 -7896
Lyn -7599
Kit -6898
Kras -5974
Yes1 -5755
Sos1 -5137
Pik3r3 -4681
Lck -3363
Stat5b -2741
Src -2599
Pik3r2 -2288
Stat3 82
Grb2 373
Hras 593
Pik3r1 1171
Fyn 2255
Stat5a 5779

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nras -8330
Stat1 -8227
Pik3ca -8013
Jak2 -7896
Lyn -7599
Kit -6898
Kras -5974
Yes1 -5755
Sos1 -5137
Pik3r3 -4681
Lck -3363
Stat5b -2741
Src -2599
Pik3r2 -2288
Stat3 82
Grb2 373
Hras 593
Pik3r1 1171
Fyn 2255
Stat5a 5779


PLATELET ADHESION TO EXPOSED COLLAGEN

PLATELET ADHESION TO EXPOSED COLLAGEN
717
set PLATELET ADHESION TO EXPOSED COLLAGEN
setSize 11
pANOVA 0.0566
s.dist 0.332
p.adjustANOVA 0.285



Top enriched genes

Top 20 genes
GeneID Gene Rank
Col1a2 7774
Col1a1 7347
Gp5 6795
Vwf 5862
Itgb1 4544
Gp1ba 3023
Fyn 2255
Fcer1g 486
Itga1 334
Itga10 -6866
Lyn -7599

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Col1a2 7774
Col1a1 7347
Gp5 6795
Vwf 5862
Itgb1 4544
Gp1ba 3023
Fyn 2255
Fcer1g 486
Itga1 334
Itga10 -6866
Lyn -7599


ASPARTATE AND ASPARAGINE METABOLISM

ASPARTATE AND ASPARAGINE METABOLISM
73
set ASPARTATE AND ASPARAGINE METABOLISM
setSize 11
pANOVA 0.0568
s.dist 0.332
p.adjustANOVA 0.285



Top enriched genes

Top 20 genes
GeneID Gene Rank
Slc25a13 7827
Aspg 6652
Folh1 5836
Gadl1 5172
Slc25a12 4582
Naalad2 3003
Aspa 1175
Got2 447
Got1 260
Nat8l -4408
Asns -6612

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Slc25a13 7827
Aspg 6652
Folh1 5836
Gadl1 5172
Slc25a12 4582
Naalad2 3003
Aspa 1175
Got2 447
Got1 260
Nat8l -4408
Asns -6612


GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS

GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS
402
set GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS
setSize 12
pANOVA 0.0472
s.dist -0.331
p.adjustANOVA 0.264



Top enriched genes

Top 20 genes
GeneID Gene Rank
Tln1 -8767
Rap1a -8221
Ptk2 -7979
Itga2b -7092
Itgb3 -5396
Rap1b -5343
Sos1 -5137
Apbb1ip -3478
Src -2599
Grb2 373
Vwf 5862
Fn1 6528

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Tln1 -8767
Rap1a -8221
Ptk2 -7979
Itga2b -7092
Itgb3 -5396
Rap1b -5343
Sos1 -5137
Apbb1ip -3478
Src -2599
Grb2 373
Vwf 5862
Fn1 6528


REGULATION OF IFNA SIGNALING

REGULATION OF IFNA SIGNALING
802
set REGULATION OF IFNA SIGNALING
setSize 12
pANOVA 0.0485
s.dist -0.329
p.adjustANOVA 0.264



Top enriched genes

Top 20 genes
GeneID Gene Rank
Stat2 -8570
Ifnar1 -8447
Stat1 -8227
Usp18 -7729
Tyk2 -5608
Ptpn6 -4543
Ptpn1 -4036
Socs3 -2442
Jak1 249
Ifnar2 2127
Ptpn11 3062
Socs1 3109

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Stat2 -8570
Ifnar1 -8447
Stat1 -8227
Usp18 -7729
Tyk2 -5608
Ptpn6 -4543
Ptpn1 -4036
Socs3 -2442
Jak1 249
Ifnar2 2127
Ptpn11 3062
Socs1 3109


VEGFR2 MEDIATED CELL PROLIFERATION

VEGFR2 MEDIATED CELL PROLIFERATION
1159
set VEGFR2 MEDIATED CELL PROLIFERATION
setSize 19
pANOVA 0.0132
s.dist -0.328
p.adjustANOVA 0.143



Top enriched genes

Top 20 genes
GeneID Gene Rank
Kdr -8948
Prkcb -8533
Nras -8330
Prkcz -7749
Itpr1 -6977
Rasa1 -6962
Calm1 -6088
Kras -5974
Pdpk1 -5921
Prkca -5046
Itpr2 -3995
Plcg1 -3767
Src -2599
Vegfa -2547
Itpr3 -1106
Hras 593
Ahcyl1 4360
Prkcd 6929
Sphk1 7755

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Kdr -8948
Prkcb -8533
Nras -8330
Prkcz -7749
Itpr1 -6977
Rasa1 -6962
Calm1 -6088
Kras -5974
Pdpk1 -5921
Prkca -5046
Itpr2 -3995
Plcg1 -3767
Src -2599
Vegfa -2547
Itpr3 -1106
Hras 593
Ahcyl1 4360
Prkcd 6929
Sphk1 7755


CD209 DC SIGN SIGNALING

CD209 DC SIGN SIGNALING
122
set CD209 DC SIGN SIGNALING
setSize 18
pANOVA 0.016
s.dist -0.328
p.adjustANOVA 0.158



Top enriched genes

Top 20 genes
GeneID Gene Rank
Nras -8330
Icam2 -7917
Lyn -7599
Crebbp -6906
Pak1 -6645
Kras -5974
Prkacb -5917
Rela -4265
Relb -3693
Ep300 -3538
Pak3 -3417
Nfkb1 -2356
Pak2 -1312
Raf1 -1126
Hras 593
Rps6ka5 1978
Fyn 2255
Prkaca 2759

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Nras -8330
Icam2 -7917
Lyn -7599
Crebbp -6906
Pak1 -6645
Kras -5974
Prkacb -5917
Rela -4265
Relb -3693
Ep300 -3538
Pak3 -3417
Nfkb1 -2356
Pak2 -1312
Raf1 -1126
Hras 593
Rps6ka5 1978
Fyn 2255
Prkaca 2759


BRANCHED CHAIN AMINO ACID CATABOLISM

BRANCHED CHAIN AMINO ACID CATABOLISM
104
set BRANCHED CHAIN AMINO ACID CATABOLISM
setSize 21
pANOVA 0.00975
s.dist 0.326
p.adjustANOVA 0.116



Top enriched genes

Top 20 genes
GeneID Gene Rank
Hsd17b10 7608
Acat1 7524
Mccc2 7514
Echs1 7001
Bckdha 6588
Bcat1 4687
Dbt 4003
Aldh6a1 3709
Acad8 3573
Slc25a44 3392
Ivd 3201
Mccc1 1693
Dld 1533
Bckdhb 1433
Bckdk 1357
Auh -374
Hibadh -714
Acadsb -1149
Hibch -1684
Bcat2 -7816

Click HERE to show all gene set members

All member genes
GeneID Gene Rank
Hsd17b10 7608
Acat1 7524
Mccc2 7514
Echs1 7001
Bckdha 6588
Bcat1 4687
Dbt 4003
Aldh6a1 3709
Acad8 3573
Slc25a44 3392
Ivd 3201
Mccc1 1693
Dld 1533
Bckdhb 1433
Bckdk 1357
Auh -374
Hibadh -714
Acadsb -1149
Hibch -1684
Bcat2 -7816
Ppm1k -8467


Here is the session info with all the versions of packages used.

sessionInfo()
## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.3                echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.4               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58.1               fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.1        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.4        
## [23] IRanges_2.30.1              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.2               stringr_1.4.1              
## [29] dplyr_1.0.10                purrr_0.3.5                
## [31] readr_2.1.3                 tidyr_1.2.1                
## [33] tibble_3.1.8                ggplot2_3.3.6              
## [35] tidyverse_1.3.2             zoo_1.8-11                 
## 
## loaded via a namespace (and not attached):
##   [1] googledrive_2.0.0      colorspace_2.0-3       ellipsis_0.3.2        
##   [4] XVector_0.36.0         fs_1.5.2               rstudioapi_0.14       
##   [7] bit64_4.0.5            AnnotationDbi_1.58.0   fansi_1.0.3           
##  [10] lubridate_1.8.0        xml2_1.3.3             codetools_0.2-18      
##  [13] splines_4.2.1          cachem_1.0.6           knitr_1.40            
##  [16] geneplotter_1.74.0     jsonlite_1.8.2         broom_1.0.1           
##  [19] annotate_1.74.0        dbplyr_2.2.1           png_0.1-7             
##  [22] shiny_1.7.2            compiler_4.2.1         httr_1.4.4            
##  [25] backports_1.4.1        assertthat_0.2.1       Matrix_1.5-1          
##  [28] fastmap_1.1.0          gargle_1.2.1           cli_3.4.1             
##  [31] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
##  [34] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
##  [37] fastmatch_1.1-3        Rcpp_1.0.9             jquerylib_0.1.4       
##  [40] cellranger_1.1.0       vctrs_0.4.2            Biostrings_2.64.1     
##  [43] svglite_2.1.0          xfun_0.33              rvest_1.0.3           
##  [46] mime_0.12              lifecycle_1.0.3        XML_3.99-0.11         
##  [49] googlesheets4_1.0.1    zlibbioc_1.42.0        scales_1.2.1          
##  [52] hms_1.1.2              promises_1.2.0.1       parallel_4.2.1        
##  [55] RColorBrewer_1.1-3     yaml_2.3.5             memoise_2.0.1         
##  [58] gridExtra_2.3          sass_0.4.2             reshape_0.8.9         
##  [61] stringi_1.7.8          RSQLite_2.2.18         highr_0.9             
##  [64] genefilter_1.78.0      caTools_1.18.2         BiocParallel_1.30.3   
##  [67] systemfonts_1.0.4      rlang_1.0.6            pkgconfig_2.0.3       
##  [70] bitops_1.0-7           evaluate_0.17          lattice_0.20-45       
##  [73] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.2.0      
##  [76] plyr_1.8.7             magrittr_2.0.3         R6_2.5.1              
##  [79] generics_0.1.3         DelayedArray_0.22.0    DBI_1.1.3             
##  [82] pillar_1.8.1           haven_2.5.1            withr_2.5.0           
##  [85] survival_3.4-0         KEGGREST_1.36.3        RCurl_1.98-1.9        
##  [88] modelr_0.1.9           crayon_1.5.2           KernSmooth_2.23-20    
##  [91] utf8_1.2.2             rmarkdown_2.17         tzdb_0.3.0            
##  [94] locfit_1.5-9.6         grid_4.2.1             readxl_1.4.1          
##  [97] data.table_1.14.2      blob_1.2.3             webshot_0.5.4         
## [100] reprex_2.0.2           digest_0.6.29          xtable_1.8-4          
## [103] httpuv_1.6.6           munsell_0.5.0          viridisLite_0.4.1     
## [106] bslib_0.4.0

END of report