Mitch Report

date generated: 2022-10-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                         x
## 0610009B22Rik  0.19606842
## 0610009E02Rik  2.50381380
## 0610009L18Rik  0.71226654
## 0610010K14Rik -0.06247159
## 0610012G03Rik -0.08438765
## 0610030E20Rik -0.30737084

Here are some metrics about the input data profile:

Profile metrics
	Profile metrics
num_genesets	1604
num_genes_in_profile	17009
duplicated_genes_present	0
num_profile_genes_in_sets	8305
num_profile_genes_not_in_sets	8704

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene sets metrics
	Gene sets metrics
num_genesets	1604
num_genesets_excluded	440
num_genesets_included	1164

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	1.96e-03	0.566	0.05280
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	7.94e-05	0.553	0.00924
SYNAPTIC ADHESION LIKE MOLECULES	21	3.89e-05	0.519	0.00503
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	3.23e-03	-0.513	0.07670
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	7.09e-04	0.505	0.03440
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	5.92e-03	-0.503	0.12300
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	6.73e-03	0.495	0.12400
CGMP EFFECTS	15	9.40e-04	0.493	0.03650
DNA METHYLATION	20	4.42e-04	-0.454	0.02450
LGI ADAM INTERACTIONS	14	3.48e-03	0.451	0.08100
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	6.92e-03	0.450	0.12400
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	1.02e-03	0.447	0.03790
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	1.12e-02	-0.442	0.14300
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	1.26e-03	0.439	0.04080
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	12	8.52e-03	-0.439	0.13000
MUCOPOLYSACCHARIDOSES	11	1.20e-02	0.437	0.14800
TRAFFICKING OF AMPA RECEPTORS	31	2.84e-05	0.434	0.00456
SHC MEDIATED CASCADE FGFR4	11	1.52e-02	-0.423	0.17500
SIGNALING BY HIPPO	20	1.24e-03	-0.417	0.04080
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	13	1.01e-02	-0.412	0.13700
HSF1 ACTIVATION	27	2.40e-04	-0.408	0.01740
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	1.31e-03	0.405	0.04130
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	2.69e-02	-0.404	0.23200
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	2.13e-02	0.401	0.20800
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	2.18e-02	-0.399	0.21000
CONDENSATION OF PROPHASE CHROMOSOMES	28	2.97e-04	-0.395	0.01820
CROSSLINKING OF COLLAGEN FIBRILS	14	1.12e-02	0.391	0.14300
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	3.24e-02	0.391	0.24800
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	1.52e-02	-0.389	0.17500
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.99e-02	-0.388	0.20200
RETROGRADE NEUROTROPHIN SIGNALLING	14	1.21e-02	0.387	0.14800
TRAF6 MEDIATED IRF7 ACTIVATION	15	1.02e-02	-0.383	0.13700
ATTENUATION PHASE	25	9.34e-04	-0.382	0.03650
PI 3K CASCADE FGFR4	11	3.04e-02	-0.377	0.24200
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	1.82e-03	0.376	0.05050
DEFECTS IN COBALAMIN B12 METABOLISM	12	2.77e-02	-0.367	0.23500
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	25	1.82e-03	-0.360	0.05050
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	1.02e-02	0.360	0.13700
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	3.88e-02	-0.360	0.27500
RRNA PROCESSING IN THE MITOCHONDRION	10	4.94e-02	0.359	0.30600
INTERLEUKIN 10 SIGNALING	19	7.48e-03	-0.354	0.12600
INTERACTION BETWEEN L1 AND ANKYRINS	29	1.04e-03	0.352	0.03790
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	2.27e-02	-0.352	0.21400
FORMATION OF THE CORNIFIED ENVELOPE	26	2.04e-03	0.349	0.05280
KERATINIZATION	26	2.04e-03	0.349	0.05280
FRS MEDIATED FGFR4 SIGNALING	13	2.97e-02	-0.348	0.24200
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	1.96e-02	0.348	0.20200
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	3.12e-02	-0.345	0.24200
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	23	4.41e-03	-0.343	0.09680
DSCAM INTERACTIONS	10	6.07e-02	0.343	0.33400

Results (complete table)

Click HERE to show results for all gene sets

Complete results
set	setSize	pANOVA	s.dist	p.adjustANOVA
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	1.96e-03	0.566000	5.28e-02
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	7.94e-05	0.553000	9.24e-03
SYNAPTIC ADHESION LIKE MOLECULES	21	3.89e-05	0.519000	5.03e-03
COMMON PATHWAY OF FIBRIN CLOT FORMATION	11	3.23e-03	-0.513000	7.67e-02
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	7.09e-04	0.505000	3.44e-02
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	5.92e-03	-0.503000	1.23e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	6.73e-03	0.495000	1.24e-01
CGMP EFFECTS	15	9.40e-04	0.493000	3.65e-02
DNA METHYLATION	20	4.42e-04	-0.454000	2.45e-02
LGI ADAM INTERACTIONS	14	3.48e-03	0.451000	8.10e-02
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	6.92e-03	0.450000	1.24e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	1.02e-03	0.447000	3.79e-02
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	1.12e-02	-0.442000	1.43e-01
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	1.26e-03	0.439000	4.08e-02
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	12	8.52e-03	-0.439000	1.30e-01
MUCOPOLYSACCHARIDOSES	11	1.20e-02	0.437000	1.48e-01
TRAFFICKING OF AMPA RECEPTORS	31	2.84e-05	0.434000	4.56e-03
SHC MEDIATED CASCADE FGFR4	11	1.52e-02	-0.423000	1.75e-01
SIGNALING BY HIPPO	20	1.24e-03	-0.417000	4.08e-02
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	13	1.01e-02	-0.412000	1.37e-01
HSF1 ACTIVATION	27	2.40e-04	-0.408000	1.74e-02
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	1.31e-03	0.405000	4.13e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	2.69e-02	-0.404000	2.32e-01
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	2.13e-02	0.401000	2.08e-01
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	2.18e-02	-0.399000	2.10e-01
CONDENSATION OF PROPHASE CHROMOSOMES	28	2.97e-04	-0.395000	1.82e-02
CROSSLINKING OF COLLAGEN FIBRILS	14	1.12e-02	0.391000	1.43e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	3.24e-02	0.391000	2.48e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	1.52e-02	-0.389000	1.75e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	1.99e-02	-0.388000	2.02e-01
RETROGRADE NEUROTROPHIN SIGNALLING	14	1.21e-02	0.387000	1.48e-01
TRAF6 MEDIATED IRF7 ACTIVATION	15	1.02e-02	-0.383000	1.37e-01
ATTENUATION PHASE	25	9.34e-04	-0.382000	3.65e-02
PI 3K CASCADE FGFR4	11	3.04e-02	-0.377000	2.42e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	1.82e-03	0.376000	5.05e-02
DEFECTS IN COBALAMIN B12 METABOLISM	12	2.77e-02	-0.367000	2.35e-01
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	25	1.82e-03	-0.360000	5.05e-02
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	1.02e-02	0.360000	1.37e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	3.88e-02	-0.360000	2.75e-01
RRNA PROCESSING IN THE MITOCHONDRION	10	4.94e-02	0.359000	3.06e-01
INTERLEUKIN 10 SIGNALING	19	7.48e-03	-0.354000	1.26e-01
INTERACTION BETWEEN L1 AND ANKYRINS	29	1.04e-03	0.352000	3.79e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	2.27e-02	-0.352000	2.14e-01
FORMATION OF THE CORNIFIED ENVELOPE	26	2.04e-03	0.349000	5.28e-02
KERATINIZATION	26	2.04e-03	0.349000	5.28e-02
FRS MEDIATED FGFR4 SIGNALING	13	2.97e-02	-0.348000	2.42e-01
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	1.96e-02	0.348000	2.02e-01
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	3.12e-02	-0.345000	2.42e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	23	4.41e-03	-0.343000	9.68e-02
DSCAM INTERACTIONS	10	6.07e-02	0.343000	3.34e-01
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	6.61e-03	0.342000	1.24e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	21	6.62e-03	0.342000	1.24e-01
RA BIOSYNTHESIS PATHWAY	14	2.83e-02	-0.339000	2.37e-01
ENDOSOMAL VACUOLAR PATHWAY	11	5.20e-02	-0.338000	3.09e-01
BIOTIN TRANSPORT AND METABOLISM	11	5.24e-02	0.338000	3.09e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	1.33e-02	-0.337000	1.59e-01
VOLTAGE GATED POTASSIUM CHANNELS	40	2.39e-04	0.336000	1.74e-02
COMPLEMENT CASCADE	26	3.16e-03	-0.334000	7.67e-02
CELLULAR HEXOSE TRANSPORT	10	7.07e-02	0.330000	3.55e-01
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	7.17e-02	0.329000	3.55e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	6.83e-04	0.327000	3.44e-02
SYNTHESIS OF PE	13	4.15e-02	-0.327000	2.89e-01
SPRY REGULATION OF FGF SIGNALING	16	2.39e-02	0.326000	2.19e-01
SHC MEDIATED CASCADE FGFR3	13	4.24e-02	-0.325000	2.89e-01
LONG TERM POTENTIATION	23	7.13e-03	0.324000	1.24e-01
ENOS ACTIVATION	11	6.57e-02	-0.321000	3.40e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	12	5.52e-02	-0.320000	3.15e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	18	2.06e-02	-0.315000	2.05e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	22	1.08e-02	-0.314000	1.42e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	3.05e-02	0.312000	2.42e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	13	5.15e-02	-0.312000	3.09e-01
THE NLRP3 INFLAMMASOME	15	3.72e-02	-0.311000	2.73e-01
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	1.01e-02	0.310000	1.37e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	1.57e-02	-0.304000	1.79e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	2.60e-02	-0.303000	2.27e-01
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	21	1.72e-02	-0.300000	1.91e-01
ANCHORING FIBRIL FORMATION	13	6.16e-02	0.299000	3.37e-01
INTERFERON GAMMA SIGNALING	78	5.21e-06	-0.298000	3.03e-03
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	4.56e-02	-0.298000	2.98e-01
REGULATED PROTEOLYSIS OF P75NTR	12	7.38e-02	-0.298000	3.55e-01
MET ACTIVATES RAS SIGNALING	10	1.09e-01	-0.293000	4.37e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	3.20e-02	-0.292000	2.47e-01
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	9.59e-02	-0.290000	4.13e-01
OLFACTORY SIGNALING PATHWAY	31	5.30e-03	-0.289000	1.12e-01
TRAF6 MEDIATED NF KB ACTIVATION	22	1.92e-02	-0.288000	2.02e-01
MET ACTIVATES RAP1 AND RAC1	11	9.82e-02	-0.288000	4.19e-01
PI 3K CASCADE FGFR3	13	7.40e-02	-0.286000	3.55e-01
ERKS ARE INACTIVATED	13	7.45e-02	0.286000	3.55e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	6.51e-02	-0.285000	3.38e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	1.24e-05	-0.285000	3.18e-03
DISEASES OF IMMUNE SYSTEM	23	1.85e-02	-0.284000	1.99e-01
INTERFERON ALPHA BETA SIGNALING	56	2.75e-04	-0.281000	1.78e-02
NEUREXINS AND NEUROLIGINS	54	3.88e-04	0.279000	2.26e-02
FORMATION OF APOPTOSOME	10	1.27e-01	-0.278000	4.69e-01
CONSTITUTIVE SIGNALING BY EGFRVIII	15	6.36e-02	-0.277000	3.38e-01
FORMATION OF THE EARLY ELONGATION COMPLEX	33	6.01e-03	0.276000	1.23e-01
DISEASES OF DNA REPAIR	11	1.16e-01	0.274000	4.54e-01
GLYCOGEN METABOLISM	25	1.79e-02	-0.274000	1.97e-01
FRS MEDIATED FGFR3 SIGNALING	15	6.66e-02	-0.274000	3.42e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	8.79e-02	0.273000	3.97e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	5.12e-02	0.273000	3.09e-01
REDUCTION OF CYTOSOLIC CA LEVELS	11	1.18e-01	0.272000	4.55e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	19	4.22e-02	0.269000	2.89e-01
INITIAL TRIGGERING OF COMPLEMENT	11	1.23e-01	-0.269000	4.67e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	6.29e-02	-0.269000	3.38e-01
SIGNALING BY FGFR4 IN DISEASE	10	1.42e-01	-0.268000	4.88e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	2.65e-02	0.267000	2.30e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	13	9.56e-02	-0.267000	4.13e-01
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	15	7.40e-02	-0.267000	3.55e-01
APOPTOSIS INDUCED DNA FRAGMENTATION	10	1.46e-01	-0.266000	4.91e-01
CA DEPENDENT EVENTS	36	6.22e-03	0.264000	1.24e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	20	4.21e-02	-0.263000	2.89e-01
ERK MAPK TARGETS	22	3.31e-02	0.263000	2.51e-01
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	3.14e-05	0.261000	4.56e-03
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	3.08e-02	0.260000	2.42e-01
SIGNALING BY BMP	25	2.47e-02	-0.259000	2.25e-01
TIGHT JUNCTION INTERACTIONS	16	7.36e-02	-0.258000	3.55e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	4.68e-02	0.257000	2.99e-01
RHO GTPASES ACTIVATE KTN1	11	1.41e-01	-0.256000	4.88e-01
SCAVENGING BY CLASS A RECEPTORS	13	1.10e-01	-0.256000	4.37e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	12	1.25e-01	0.256000	4.69e-01
SIGNALING BY ERBB2 IN CANCER	25	2.97e-02	-0.251000	2.42e-01
CRMPS IN SEMA3A SIGNALING	16	8.36e-02	0.250000	3.86e-01
PHASE 0 RAPID DEPOLARISATION	31	1.63e-02	0.249000	1.84e-01
UNWINDING OF DNA	12	1.35e-01	0.249000	4.79e-01
EFFECTS OF PIP2 HYDROLYSIS	27	2.50e-02	0.249000	2.26e-01
RESOLUTION OF ABASIC SITES AP SITES	38	7.88e-03	0.249000	1.26e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	1.74e-01	0.248000	5.31e-01
INFLAMMASOMES	19	6.28e-02	-0.247000	3.38e-01
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	51	2.33e-03	0.246000	5.90e-02
NCAM SIGNALING FOR NEURITE OUT GROWTH	57	1.35e-03	0.245000	4.14e-02
PRC2 METHYLATES HISTONES AND DNA	29	2.23e-02	-0.245000	2.13e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	45	4.70e-03	-0.244000	1.01e-01
MEIOTIC RECOMBINATION	38	9.40e-03	-0.244000	1.37e-01
DAG AND IP3 SIGNALING	40	7.99e-03	0.242000	1.26e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	12	1.46e-01	-0.242000	4.91e-01
HIV TRANSCRIPTION ELONGATION	42	7.02e-03	0.240000	1.24e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	1.26e-02	-0.240000	1.53e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	1.89e-01	0.240000	5.51e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	90	8.82e-05	0.239000	9.33e-03
VLDLR INTERNALISATION AND DEGRADATION	12	1.53e-01	0.238000	5.02e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	39	1.01e-02	-0.238000	1.37e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	25	4.03e-02	-0.237000	2.84e-01
RHOBTB2 GTPASE CYCLE	23	5.06e-02	-0.236000	3.09e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	1.58e-01	-0.235000	5.07e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	1.42e-01	-0.235000	4.88e-01
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	64	1.23e-03	-0.234000	4.08e-02
ACYL CHAIN REMODELLING OF PS	14	1.31e-01	0.233000	4.72e-01
AMINE LIGAND BINDING RECEPTORS	31	2.58e-02	0.231000	2.27e-01
IRAK4 DEFICIENCY TLR2 4	12	1.67e-01	-0.230000	5.22e-01
ERYTHROPOIETIN ACTIVATES RAS	13	1.51e-01	-0.230000	5.00e-01
FCERI MEDIATED CA 2 MOBILIZATION	25	4.77e-02	-0.229000	2.99e-01
CALNEXIN CALRETICULIN CYCLE	26	4.38e-02	-0.228000	2.94e-01
POTASSIUM CHANNELS	90	1.86e-04	0.228000	1.67e-02
SUMOYLATION OF TRANSCRIPTION FACTORS	17	1.04e-01	-0.228000	4.27e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	1.74e-01	0.226000	5.31e-01
SURFACTANT METABOLISM	16	1.17e-01	-0.226000	4.54e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	1.77e-01	-0.225000	5.33e-01
NONHOMOLOGOUS END JOINING NHEJ	44	9.97e-03	-0.225000	1.37e-01
GLUCONEOGENESIS	27	4.40e-02	0.224000	2.94e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	1.63e-01	0.224000	5.15e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	9.23e-02	0.223000	4.07e-01
GLYCOGEN SYNTHESIS	14	1.49e-01	-0.223000	4.96e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	1.35e-01	-0.223000	4.79e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	45	9.80e-03	-0.223000	1.37e-01
HS GAG BIOSYNTHESIS	29	3.83e-02	0.222000	2.74e-01
NCAM1 INTERACTIONS	37	1.99e-02	0.221000	2.02e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	6.70e-02	-0.221000	3.42e-01
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	95	2.59e-04	-0.217000	1.78e-02
RECYCLING PATHWAY OF L1	40	1.87e-02	0.215000	1.99e-01
DARPP 32 EVENTS	23	7.44e-02	0.215000	3.55e-01
GP1B IX V ACTIVATION SIGNALLING	11	2.17e-01	0.215000	5.93e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	10	2.42e-01	0.214000	6.30e-01
NETRIN 1 SIGNALING	48	1.06e-02	0.213000	1.40e-01
AMINO ACIDS REGULATE MTORC1	51	8.59e-03	0.213000	1.30e-01
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	3.46e-02	-0.213000	2.57e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	1.42e-01	-0.212000	4.88e-01
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	1.19e-01	0.212000	4.58e-01
RHOBTB3 ATPASE CYCLE	10	2.46e-01	-0.212000	6.35e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	7.30e-02	-0.211000	3.55e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	84	8.13e-04	0.211000	3.51e-02
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	107	1.62e-04	-0.211000	1.57e-02
EUKARYOTIC TRANSLATION ELONGATION	88	6.66e-04	-0.210000	3.44e-02
NEPHRIN FAMILY INTERACTIONS	22	9.07e-02	0.208000	4.01e-01
HDR THROUGH MMEJ ALT NHEJ	10	2.55e-01	0.208000	6.39e-01
AMYLOID FIBER FORMATION	57	6.79e-03	-0.207000	1.24e-01
RHOBTB GTPASE CYCLE	35	3.43e-02	-0.207000	2.56e-01
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	9.32e-02	0.207000	4.10e-01
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	14	1.82e-01	-0.206000	5.40e-01
HS GAG DEGRADATION	20	1.10e-01	0.206000	4.37e-01
MTORC1 MEDIATED SIGNALLING	24	8.13e-02	0.206000	3.80e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	22	9.53e-02	0.205000	4.13e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	23	8.88e-02	-0.205000	3.97e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	1.73e-01	0.203000	5.31e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	2.05e-01	0.203000	5.78e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	1.90e-01	-0.202000	5.51e-01
RHOBTB1 GTPASE CYCLE	23	9.40e-02	-0.202000	4.10e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	1.28e-01	-0.202000	4.69e-01
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	2.57e-02	-0.201000	2.27e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	41	2.59e-02	-0.201000	2.27e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	2.28e-01	-0.201000	6.15e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	6.65e-02	0.200000	3.42e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	3.80e-02	0.200000	2.74e-01
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	23	9.73e-02	-0.200000	4.17e-01
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	2.53e-01	0.199000	6.37e-01
PI 3K CASCADE FGFR2	16	1.68e-01	-0.199000	5.24e-01
HSF1 DEPENDENT TRANSACTIVATION	35	4.17e-02	-0.199000	2.89e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	1.25e-01	0.198000	4.69e-01
FRS MEDIATED FGFR2 SIGNALING	18	1.45e-01	-0.198000	4.91e-01
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	12	2.40e-01	0.196000	6.29e-01
RECEPTOR MEDIATED MITOPHAGY	11	2.60e-01	0.196000	6.43e-01
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	6.41e-02	0.195000	3.38e-01
SIGNALING BY PDGFR IN DISEASE	20	1.31e-01	-0.195000	4.72e-01
PLATELET SENSITIZATION BY LDL	15	1.91e-01	-0.195000	5.51e-01
CHONDROITIN SULFATE BIOSYNTHESIS	19	1.42e-01	0.194000	4.88e-01
HIV ELONGATION ARREST AND RECOVERY	32	5.82e-02	0.194000	3.28e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	14	2.13e-01	-0.192000	5.89e-01
REGULATION OF FZD BY UBIQUITINATION	20	1.39e-01	-0.191000	4.88e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	59	1.14e-02	0.190000	1.44e-01
PURINE SALVAGE	12	2.54e-01	0.190000	6.39e-01
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	1.75e-01	0.190000	5.31e-01
INSULIN RECEPTOR RECYCLING	20	1.42e-01	0.190000	4.88e-01
CD209 DC SIGN SIGNALING	18	1.65e-01	-0.189000	5.16e-01
SIGNALING BY CSF3 G CSF	29	7.85e-02	-0.189000	3.69e-01
SIGNALING BY ERBB4	57	1.38e-02	-0.189000	1.63e-01
DUAL INCISION IN GG NER	41	3.70e-02	0.188000	2.73e-01
INTERLEUKIN 37 SIGNALING	19	1.57e-01	-0.188000	5.07e-01
HEME BIOSYNTHESIS	13	2.44e-01	0.187000	6.33e-01
COHESIN LOADING ONTO CHROMATIN	10	3.09e-01	-0.186000	6.89e-01
SHC1 EVENTS IN EGFR SIGNALING	11	2.88e-01	-0.185000	6.70e-01
RUNX3 REGULATES NOTCH SIGNALING	13	2.51e-01	-0.184000	6.35e-01
SEROTONIN RECEPTORS	10	3.15e-01	0.183000	6.92e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	2.95e-01	-0.182000	6.77e-01
P38MAPK EVENTS	12	2.76e-01	-0.182000	6.59e-01
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	23	1.31e-01	-0.182000	4.72e-01
GLYCOSAMINOGLYCAN METABOLISM	114	8.11e-04	0.182000	3.51e-02
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	3.20e-01	0.181000	6.93e-01
PENTOSE PHOSPHATE PATHWAY	13	2.58e-01	-0.181000	6.43e-01
DNA DAMAGE RECOGNITION IN GG NER	38	5.44e-02	0.180000	3.12e-01
BUDDING AND MATURATION OF HIV VIRION	27	1.05e-01	0.180000	4.27e-01
SODIUM CALCIUM EXCHANGERS	10	3.24e-01	0.180000	6.93e-01
NEURONAL SYSTEM	364	3.95e-09	0.180000	4.60e-06
VXPX CARGO TARGETING TO CILIUM	19	1.78e-01	0.179000	5.35e-01
RNA POLYMERASE III CHAIN ELONGATION	18	1.91e-01	0.178000	5.51e-01
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	2.34e-01	0.178000	6.24e-01
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	3.31e-01	0.178000	6.94e-01
EARLY PHASE OF HIV LIFE CYCLE	14	2.50e-01	-0.177000	6.35e-01
ACYL CHAIN REMODELLING OF PG	10	3.33e-01	0.177000	6.95e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	7.43e-02	-0.177000	3.55e-01
L1CAM INTERACTIONS	109	1.44e-03	0.177000	4.31e-02
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	1.07e-01	0.176000	4.31e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	1.07e-01	0.176000	4.31e-01
DEADENYLATION OF MRNA	25	1.28e-01	0.176000	4.69e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	5.27e-02	0.175000	3.09e-01
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	33	8.22e-02	-0.175000	3.83e-01
GLUCOSE METABOLISM	79	7.36e-03	0.174000	1.26e-01
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	9.38e-02	0.174000	4.10e-01
SIGNALING BY FGFR1 IN DISEASE	32	8.95e-02	-0.173000	3.98e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	2.62e-01	0.173000	6.44e-01
ANTIGEN PROCESSING CROSS PRESENTATION	95	3.66e-03	-0.173000	8.35e-02
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	51	3.32e-02	-0.172000	2.51e-01
DERMATAN SULFATE BIOSYNTHESIS	11	3.22e-01	0.172000	6.93e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	2.35e-01	0.172000	6.25e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	1.04e-01	0.171000	4.27e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	26	1.30e-01	0.171000	4.72e-01
VEGFR2 MEDIATED VASCULAR PERMEABILITY	26	1.31e-01	-0.171000	4.72e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	13	2.86e-01	-0.171000	6.70e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	1.40e-01	-0.171000	4.88e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	2.88e-01	-0.170000	6.70e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	1.87e-01	-0.170000	5.48e-01
NUCLEOTIDE SALVAGE	21	1.80e-01	0.169000	5.38e-01
PRE NOTCH EXPRESSION AND PROCESSING	64	2.03e-02	-0.168000	2.04e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	4.72e-02	0.167000	2.99e-01
PURINE CATABOLISM	16	2.48e-01	0.167000	6.35e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	3.18e-01	-0.167000	6.92e-01
RHO GTPASES ACTIVATE PKNS	48	4.60e-02	-0.167000	2.98e-01
REGULATION OF IFNG SIGNALING	13	2.99e-01	-0.166000	6.78e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	25	1.51e-01	-0.166000	5.00e-01
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	1.10e-01	0.166000	4.37e-01
ANTIMICROBIAL PEPTIDES	16	2.51e-01	-0.166000	6.35e-01
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	3.21e-01	0.165000	6.93e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	3.09e-02	0.165000	2.42e-01
TBC RABGAPS	42	6.43e-02	0.165000	3.38e-01
APOPTOTIC FACTOR MEDIATED RESPONSE	18	2.27e-01	-0.165000	6.12e-01
ACYL CHAIN REMODELLING OF PC	17	2.40e-01	0.165000	6.29e-01
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	1.57e-01	0.163000	5.07e-01
PI3K EVENTS IN ERBB2 SIGNALING	15	2.73e-01	-0.163000	6.55e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	140	8.54e-04	0.163000	3.55e-02
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	1.76e-01	-0.163000	5.31e-01
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	30	1.23e-01	0.163000	4.67e-01
SELENOAMINO ACID METABOLISM	110	3.21e-03	-0.163000	7.67e-02
ER QUALITY CONTROL COMPARTMENT ERQC	21	1.98e-01	-0.162000	5.62e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	2.21e-01	0.162000	5.99e-01
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	2.47e-01	-0.162000	6.35e-01
ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES	10	3.76e-01	0.162000	7.29e-01
SARS COV 1 INFECTION	48	5.28e-02	0.162000	3.09e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	32	1.17e-01	-0.160000	4.54e-01
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	3.18e-01	-0.160000	6.92e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	1.60e-01	-0.159000	5.11e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	3.61e-01	-0.159000	7.24e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	18	2.44e-01	0.159000	6.33e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	1.40e-01	-0.159000	4.88e-01
GLYCOLYSIS	65	2.76e-02	0.158000	2.35e-01
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	3.07e-01	0.158000	6.89e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	52	4.95e-02	-0.158000	3.06e-01
SIGNALING BY EGFR IN CANCER	22	2.02e-01	-0.157000	5.71e-01
JOSEPHIN DOMAIN DUBS	11	3.68e-01	0.157000	7.28e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	47	6.39e-02	-0.156000	3.38e-01
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	3.52e-01	-0.155000	7.13e-01
FGFR2 LIGAND BINDING AND ACTIVATION	11	3.75e-01	-0.154000	7.29e-01
FORMATION OF TC NER PRE INCISION COMPLEX	53	5.26e-02	0.154000	3.09e-01
METABOLISM OF PORPHYRINS	19	2.47e-01	0.154000	6.35e-01
HDACS DEACETYLATE HISTONES	47	6.91e-02	-0.153000	3.50e-01
INTRAFLAGELLAR TRANSPORT	49	6.45e-02	0.153000	3.38e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	4.04e-01	-0.152000	7.51e-01
SHC1 EVENTS IN ERBB4 SIGNALING	13	3.42e-01	-0.152000	7.02e-01
PROTEIN UBIQUITINATION	70	2.79e-02	-0.152000	2.35e-01
MRNA SPLICING MINOR PATHWAY	52	5.81e-02	0.152000	3.28e-01
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	3.09e-01	-0.152000	6.89e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	2.65e-01	-0.152000	6.48e-01
FORMATION OF INCISION COMPLEX IN GG NER	43	8.55e-02	0.152000	3.92e-01
ESTROGEN DEPENDENT GENE EXPRESSION	102	8.28e-03	-0.151000	1.28e-01
ERBB2 REGULATES CELL MOTILITY	14	3.27e-01	-0.151000	6.94e-01
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	2.31e-01	0.151000	6.19e-01
N GLYCAN ANTENNAE ELONGATION	15	3.11e-01	-0.151000	6.90e-01
TRNA PROCESSING	105	7.72e-03	0.151000	1.26e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	1.70e-01	0.150000	5.26e-01
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	3.92e-01	-0.149000	7.45e-01
DUAL INCISION IN TC NER	65	3.76e-02	0.149000	2.74e-01
NUCLEAR ENVELOPE BREAKDOWN	49	7.15e-02	0.149000	3.55e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	2.31e-02	0.149000	2.15e-01
ION HOMEOSTASIS	48	7.45e-02	0.149000	3.55e-01
TRANSCRIPTIONAL REGULATION BY MECP2	60	4.63e-02	0.149000	2.98e-01
DAP12 INTERACTIONS	31	1.53e-01	-0.148000	5.02e-01
VIRAL MESSENGER RNA SYNTHESIS	42	9.64e-02	0.148000	4.14e-01
EGFR DOWNREGULATION	28	1.75e-01	0.148000	5.31e-01
PKMTS METHYLATE HISTONE LYSINES	49	7.35e-02	-0.148000	3.55e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	13	3.57e-01	-0.148000	7.21e-01
DISEASES OF PROGRAMMED CELL DEATH	54	6.08e-02	-0.148000	3.34e-01
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	4.47e-02	0.147000	2.96e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	3.08e-01	-0.147000	6.89e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	3.58e-01	-0.147000	7.21e-01
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	1.94e-01	0.147000	5.56e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	2.94e-01	0.147000	6.77e-01
INTERFERON SIGNALING	166	1.11e-03	-0.147000	3.92e-02
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	177	8.02e-04	0.146000	3.51e-02
INTERLEUKIN 7 SIGNALING	20	2.58e-01	0.146000	6.43e-01
NUCLEAR ENVELOPE NE REASSEMBLY	64	4.46e-02	0.145000	2.96e-01
RAP1 SIGNALLING	15	3.32e-01	0.145000	6.95e-01
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	3.86e-01	-0.145000	7.42e-01
MTOR SIGNALLING	40	1.14e-01	0.144000	4.50e-01
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	83	2.37e-02	-0.144000	2.19e-01
KERATAN SULFATE DEGRADATION	11	4.09e-01	0.144000	7.51e-01
INTRA GOLGI TRAFFIC	43	1.04e-01	0.143000	4.27e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	49	8.27e-02	-0.143000	3.84e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	1.05e-01	0.143000	4.27e-01
SHC MEDIATED CASCADE FGFR1	15	3.40e-01	-0.142000	7.02e-01
METALLOPROTEASE DUBS	26	2.10e-01	-0.142000	5.85e-01
DEADENYLATION DEPENDENT MRNA DECAY	55	6.85e-02	0.142000	3.48e-01
INTERLEUKIN 6 SIGNALING	10	4.37e-01	-0.142000	7.74e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	4.39e-01	-0.141000	7.74e-01
SIGNAL TRANSDUCTION BY L1	21	2.63e-01	0.141000	6.47e-01
APC CDC20 MEDIATED DEGRADATION OF NEK2A	25	2.24e-01	0.141000	6.05e-01
PHASE 2 PLATEAU PHASE	13	3.80e-01	0.141000	7.34e-01
TRANSMISSION ACROSS CHEMICAL SYNAPSES	236	2.07e-04	0.140000	1.72e-02
EUKARYOTIC TRANSLATION INITIATION	115	9.38e-03	-0.140000	1.37e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	1.85e-01	-0.140000	5.44e-01
LYSINE CATABOLISM	11	4.22e-01	-0.140000	7.62e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	1.59e-01	-0.140000	5.08e-01
GLYCOGEN STORAGE DISEASES	12	4.03e-01	-0.140000	7.51e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	1.89e-01	0.139000	5.51e-01
GPVI MEDIATED ACTIVATION CASCADE	31	1.84e-01	-0.138000	5.44e-01
OPIOID SIGNALLING	85	2.89e-02	0.137000	2.40e-01
REGULATION OF INSULIN SECRETION	70	4.77e-02	0.137000	2.99e-01
G2 M DNA DAMAGE CHECKPOINT	67	5.33e-02	-0.137000	3.09e-01
G0 AND EARLY G1	25	2.38e-01	-0.136000	6.28e-01
INTERLEUKIN 6 FAMILY SIGNALING	19	3.04e-01	-0.136000	6.86e-01
NUCLEOTIDE EXCISION REPAIR	110	1.37e-02	0.136000	1.63e-01
INHIBITION OF DNA RECOMBINATION AT TELOMERE	36	1.58e-01	-0.136000	5.07e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	2.09e-01	0.135000	5.85e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	49	1.05e-01	0.134000	4.27e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA	13	4.07e-01	0.133000	7.51e-01
RHOC GTPASE CYCLE	73	5.06e-02	-0.132000	3.09e-01
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	78	4.36e-02	0.132000	2.94e-01
SHC1 EVENTS IN ERBB2 SIGNALING	21	2.95e-01	-0.132000	6.77e-01
MRNA CAPPING	29	2.19e-01	0.132000	5.97e-01
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	31	2.07e-01	-0.131000	5.82e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	25	2.57e-01	-0.131000	6.43e-01
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	3.65e-01	0.131000	7.27e-01
SIGNALING BY NTRK2 TRKB	24	2.70e-01	0.130000	6.52e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	3.27e-01	0.130000	6.94e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	42	1.45e-01	-0.130000	4.91e-01
MITOTIC TELOPHASE CYTOKINESIS	13	4.18e-01	-0.130000	7.60e-01
INTEGRIN CELL SURFACE INTERACTIONS	68	6.49e-02	-0.129000	3.38e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	4.19e-01	-0.129000	7.60e-01
REPRESSION OF WNT TARGET GENES	14	4.02e-01	-0.129000	7.51e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	3.87e-01	-0.129000	7.42e-01
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	84	4.14e-02	0.129000	2.89e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	3.89e-01	-0.129000	7.42e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	73	5.95e-02	-0.128000	3.30e-01
NEUTROPHIL DEGRANULATION	390	1.64e-05	-0.127000	3.18e-03
ION TRANSPORT BY P TYPE ATPASES	47	1.31e-01	0.127000	4.72e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	1.93e-01	-0.127000	5.54e-01
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	3.51e-01	-0.127000	7.13e-01
SENSORY PROCESSING OF SOUND	61	8.87e-02	0.126000	3.97e-01
NONSENSE MEDIATED DECAY NMD	110	2.28e-02	-0.126000	2.14e-01
TRNA PROCESSING IN THE NUCLEUS	56	1.04e-01	0.126000	4.27e-01
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	2.51e-01	0.125000	6.35e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	4.60e-02	0.125000	2.98e-01
INTEGRATION OF ENERGY METABOLISM	96	3.42e-02	0.125000	2.56e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	2.11e-01	0.124000	5.85e-01
GENERATION OF SECOND MESSENGER MOLECULES	18	3.62e-01	-0.124000	7.24e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	3.63e-01	-0.124000	7.24e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	4.59e-01	-0.124000	7.88e-01
APOPTOTIC EXECUTION PHASE	45	1.52e-01	-0.124000	5.00e-01
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	30	2.42e-01	0.123000	6.30e-01
SNRNP ASSEMBLY	51	1.27e-01	0.123000	4.69e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	3.93e-01	0.123000	7.47e-01
NOD1 2 SIGNALING PATHWAY	34	2.14e-01	-0.123000	5.90e-01
CHAPERONE MEDIATED AUTOPHAGY	20	3.44e-01	-0.122000	7.04e-01
SIGNALING BY FLT3 FUSION PROTEINS	18	3.70e-01	-0.122000	7.29e-01
ERBB2 ACTIVATES PTK6 SIGNALING	11	4.83e-01	-0.122000	7.96e-01
IRAK1 RECRUITS IKK COMPLEX	14	4.29e-01	-0.122000	7.70e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	28	2.65e-01	0.122000	6.48e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	51	1.33e-01	-0.122000	4.75e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	1.46e-01	0.121000	4.91e-01
NEGATIVE REGULATION OF MAPK PATHWAY	43	1.70e-01	0.121000	5.26e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	6.40e-02	0.121000	3.38e-01
RND1 GTPASE CYCLE	38	1.99e-01	-0.121000	5.64e-01
FGFR1 MUTANT RECEPTOR ACTIVATION	25	2.98e-01	-0.120000	6.78e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	2.89e-01	0.120000	6.70e-01
CARDIAC CONDUCTION	108	3.10e-02	0.120000	2.42e-01
STRIATED MUSCLE CONTRACTION	24	3.08e-01	0.120000	6.89e-01
CS DS DEGRADATION	14	4.37e-01	0.120000	7.74e-01
FCGR3A MEDIATED IL10 SYNTHESIS	33	2.34e-01	-0.120000	6.24e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	3.11e-01	-0.120000	6.90e-01
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	64	9.86e-02	-0.119000	4.19e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	25	3.05e-01	-0.119000	6.88e-01
FRS MEDIATED FGFR1 SIGNALING	17	3.99e-01	-0.118000	7.51e-01
GAB1 SIGNALOSOME	14	4.44e-01	-0.118000	7.76e-01
MEIOTIC SYNAPSIS	41	1.95e-01	-0.117000	5.57e-01
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	17	4.04e-01	0.117000	7.51e-01
HEME SIGNALING	44	1.80e-01	0.117000	5.38e-01
SIGNALING BY RETINOIC ACID	34	2.41e-01	-0.116000	6.29e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	4.52e-01	-0.116000	7.83e-01
SIGNALING BY NTRK3 TRKC	17	4.07e-01	0.116000	7.51e-01
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	3.37e-01	0.116000	6.99e-01
VEGFR2 MEDIATED CELL PROLIFERATION	19	3.85e-01	-0.115000	7.42e-01
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	20	3.73e-01	0.115000	7.29e-01
G PROTEIN MEDIATED EVENTS	51	1.57e-01	0.115000	5.07e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	8.46e-02	0.114000	3.89e-01
METABOLISM OF CARBOHYDRATES	257	1.63e-03	0.114000	4.76e-02
SUPPRESSION OF PHAGOSOMAL MATURATION	13	4.76e-01	-0.114000	7.90e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	49	1.69e-01	0.114000	5.26e-01
DNA DAMAGE BYPASS	48	1.74e-01	0.113000	5.31e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	168	1.16e-02	0.113000	1.46e-01
DAP12 SIGNALING	24	3.39e-01	-0.113000	7.01e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	62	1.26e-01	-0.112000	4.69e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	4.66e-01	0.112000	7.88e-01
SIGNALING BY NUCLEAR RECEPTORS	224	3.83e-03	-0.112000	8.57e-02
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	77	8.86e-02	-0.112000	3.97e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	92	6.34e-02	-0.112000	3.38e-01
INFLUENZA INFECTION	146	1.98e-02	-0.112000	2.02e-01
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	1.39e-01	-0.111000	4.88e-01
PROLACTIN RECEPTOR SIGNALING	12	5.05e-01	-0.111000	8.07e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	547	9.74e-06	-0.111000	3.18e-03
VITAMIN B5 PANTOTHENATE METABOLISM	15	4.61e-01	-0.110000	7.88e-01
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	34	2.67e-01	0.110000	6.51e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	1.28e-01	0.109000	4.69e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	2.10e-01	0.109000	5.85e-01
NUCLEOBASE CATABOLISM	31	2.95e-01	0.109000	6.77e-01
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	4.98e-01	-0.109000	8.06e-01
PI 3K CASCADE FGFR1	15	4.67e-01	-0.109000	7.88e-01
MEIOSIS	64	1.34e-01	-0.108000	4.76e-01
LATE ENDOSOMAL MICROAUTOPHAGY	31	2.97e-01	0.108000	6.78e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	1.44e-01	0.108000	4.91e-01
ESR MEDIATED SIGNALING	165	1.72e-02	-0.108000	1.91e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	27	3.35e-01	0.107000	6.97e-01
AUTOPHAGY	138	3.01e-02	0.107000	2.42e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	86	8.65e-02	0.107000	3.95e-01
PLATELET CALCIUM HOMEOSTASIS	25	3.55e-01	0.107000	7.19e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	3.31e-01	-0.106000	6.94e-01
CELL JUNCTION ORGANIZATION	73	1.17e-01	-0.106000	4.54e-01
NEDDYLATION	217	7.74e-03	0.105000	1.26e-01
LAMININ INTERACTIONS	27	3.46e-01	-0.105000	7.06e-01
FATTY ACID METABOLISM	144	3.02e-02	-0.105000	2.42e-01
INWARDLY RECTIFYING K CHANNELS	31	3.15e-01	0.104000	6.92e-01
SIGNALING BY TGFB FAMILY MEMBERS	97	7.69e-02	-0.104000	3.65e-01
INTERLEUKIN 20 FAMILY SIGNALING	14	5.01e-01	0.104000	8.06e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	67	1.42e-01	-0.104000	4.88e-01
RHOQ GTPASE CYCLE	58	1.73e-01	-0.103000	5.31e-01
PEXOPHAGY	11	5.54e-01	0.103000	8.32e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	48	2.18e-01	-0.103000	5.93e-01
P75NTR SIGNALS VIA NF KB	16	4.76e-01	-0.103000	7.90e-01
TRANSLESION SYNTHESIS BY POLH	19	4.38e-01	0.103000	7.74e-01
TOLL LIKE RECEPTOR CASCADES	137	3.83e-02	-0.103000	2.74e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	4.92e-01	-0.102000	8.01e-01
SARS COV 2 INFECTION	65	1.55e-01	0.102000	5.05e-01
MITOPHAGY	29	3.44e-01	0.102000	7.04e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	4.32e-01	-0.101000	7.74e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	179	1.94e-02	-0.101000	2.02e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	32	3.21e-01	0.101000	6.93e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	3.64e-01	0.101000	7.26e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	2.89e-01	0.101000	6.70e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	4.25e-01	0.101000	7.66e-01
REGULATED NECROSIS	46	2.39e-01	-0.100000	6.29e-01
GOLGI TO ER RETROGRADE TRANSPORT	119	5.86e-02	0.100000	3.28e-01
PYRIMIDINE CATABOLISM	10	5.84e-01	0.100000	8.41e-01
NRAGE SIGNALS DEATH THROUGH JNK	56	1.95e-01	0.100000	5.57e-01
SIGNALING BY SCF KIT	41	2.69e-01	-0.099900	6.51e-01
HYALURONAN METABOLISM	15	5.04e-01	0.099500	8.07e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	2.49e-01	0.099400	6.35e-01
LYSOSOME VESICLE BIOGENESIS	33	3.25e-01	0.099100	6.94e-01
SULFUR AMINO ACID METABOLISM	23	4.11e-01	-0.099000	7.52e-01
IRS MEDIATED SIGNALLING	37	2.99e-01	-0.098800	6.78e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	24	4.04e-01	0.098400	7.51e-01
SIGNALING BY NTRKS	130	5.32e-02	0.098300	3.09e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	4.15e-01	-0.098200	7.55e-01
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	4.47e-01	0.098200	7.79e-01
ION CHANNEL TRANSPORT	139	4.60e-02	0.098100	2.98e-01
AGGREPHAGY	35	3.17e-01	0.097800	6.92e-01
AURKA ACTIVATION BY TPX2	71	1.56e-01	0.097500	5.06e-01
SIGNALING BY ACTIVIN	12	5.60e-01	-0.097100	8.34e-01
REPRODUCTION	74	1.49e-01	-0.097100	4.96e-01
RHOF GTPASE CYCLE	40	2.88e-01	-0.097000	6.70e-01
PARASITE INFECTION	56	2.10e-01	0.096900	5.85e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	4.54e-01	0.096800	7.84e-01
CLATHRIN MEDIATED ENDOCYTOSIS	134	5.33e-02	0.096700	3.09e-01
REGULATION OF TLR BY ENDOGENOUS LIGAND	11	5.79e-01	-0.096700	8.41e-01
RHOG GTPASE CYCLE	73	1.55e-01	-0.096400	5.05e-01
E2F MEDIATED REGULATION OF DNA REPLICATION	19	4.68e-01	-0.096200	7.88e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	41	2.87e-01	-0.096000	6.70e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	21	4.48e-01	-0.095700	7.79e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	3.73e-01	0.095700	7.29e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	3.42e-01	0.095600	7.02e-01
BASIGIN INTERACTIONS	22	4.38e-01	-0.095500	7.74e-01
EPH EPHRIN SIGNALING	90	1.21e-01	0.094700	4.61e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	39	3.07e-01	-0.094500	6.89e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	285	6.40e-03	0.094000	1.24e-01
PEROXISOMAL PROTEIN IMPORT	58	2.16e-01	-0.094000	5.91e-01
RET SIGNALING	37	3.24e-01	0.093700	6.93e-01
RHO GTPASES ACTIVATE IQGAPS	23	4.39e-01	0.093200	7.74e-01
G ALPHA S SIGNALLING EVENTS	104	1.01e-01	0.093000	4.26e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	3.28e-01	0.092900	6.94e-01
ZINC TRANSPORTERS	15	5.34e-01	0.092800	8.23e-01
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	3.79e-01	0.092800	7.33e-01
INTERLEUKIN 12 FAMILY SIGNALING	43	2.94e-01	-0.092500	6.77e-01
CARNITINE METABOLISM	14	5.49e-01	-0.092500	8.30e-01
PHOSPHORYLATION OF THE APC C	17	5.09e-01	0.092400	8.09e-01
INNATE IMMUNE SYSTEM	781	1.37e-05	-0.092000	3.18e-03
PLATELET HOMEOSTASIS	77	1.64e-01	0.091800	5.16e-01
INTEGRIN SIGNALING	24	4.37e-01	-0.091600	7.74e-01
REGULATION OF IFNA SIGNALING	12	5.83e-01	-0.091600	8.41e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	5.53e-01	0.091500	8.32e-01
NUCLEAR IMPORT OF REV PROTEIN	32	3.72e-01	0.091200	7.29e-01
ASPARAGINE N LINKED GLYCOSYLATION	281	8.78e-03	0.091000	1.31e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	32	3.76e-01	-0.090500	7.29e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	2.31e-01	-0.090200	6.19e-01
MHC CLASS II ANTIGEN PRESENTATION	103	1.14e-01	0.090200	4.49e-01
NEGATIVE REGULATION OF FLT3	14	5.60e-01	0.090100	8.34e-01
SIGNALLING TO RAS	19	4.98e-01	-0.089700	8.06e-01
C TYPE LECTIN RECEPTORS CLRS	112	1.05e-01	-0.088800	4.27e-01
RUNX2 REGULATES BONE DEVELOPMENT	29	4.09e-01	-0.088700	7.51e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	5.04e-01	-0.088500	8.07e-01
NICOTINAMIDE SALVAGING	16	5.40e-01	0.088500	8.27e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	22	4.75e-01	0.088000	7.90e-01
PYRIMIDINE SALVAGE	10	6.31e-01	0.087600	8.71e-01
METABOLISM OF COFACTORS	18	5.20e-01	-0.087600	8.17e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	3.99e-01	0.087500	7.51e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	20	4.99e-01	-0.087400	8.06e-01
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	4.68e-01	0.087400	7.88e-01
NUCLEAR SIGNALING BY ERBB4	31	4.00e-01	-0.087300	7.51e-01
SYNDECAN INTERACTIONS	26	4.41e-01	-0.087300	7.76e-01
MUSCLE CONTRACTION	159	5.86e-02	0.087000	3.28e-01
KERATAN SULFATE KERATIN METABOLISM	30	4.10e-01	0.087000	7.51e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	15	5.60e-01	0.086900	8.34e-01
RAC2 GTPASE CYCLE	86	1.64e-01	-0.086900	5.16e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	11	6.18e-01	-0.086800	8.65e-01
FCERI MEDIATED MAPK ACTIVATION	28	4.27e-01	-0.086800	7.67e-01
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	59	2.50e-01	0.086700	6.35e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	2.37e-01	0.086200	6.28e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	13	5.91e-01	-0.086100	8.46e-01
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	2.77e-01	0.085600	6.59e-01
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	6.23e-01	-0.085500	8.67e-01
METHYLATION	12	6.08e-01	-0.085400	8.57e-01
SIGNALING BY PTK6	51	2.92e-01	-0.085300	6.76e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	50	2.97e-01	0.085200	6.78e-01
GROWTH HORMONE RECEPTOR SIGNALING	21	5.01e-01	-0.084800	8.06e-01
TERMINATION OF TRANSLESION DNA SYNTHESIS	32	4.07e-01	0.084800	7.51e-01
PIWI INTERACTING RNA PIRNA BIOGENESIS	22	4.93e-01	0.084500	8.01e-01
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	39	3.62e-01	0.084400	7.24e-01
SIGNALING BY INTERLEUKINS	349	6.97e-03	-0.084300	1.24e-01
FATTY ACYL COA BIOSYNTHESIS	32	4.10e-01	-0.084200	7.51e-01
RHOH GTPASE CYCLE	37	3.76e-01	-0.084200	7.29e-01
INTERLEUKIN RECEPTOR SHC SIGNALING	20	5.15e-01	-0.084100	8.16e-01
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	5.28e-01	0.083700	8.22e-01
NEUROTRANSMITTER RELEASE CYCLE	48	3.19e-01	0.083200	6.92e-01
MET RECEPTOR RECYCLING	10	6.49e-01	-0.083100	8.80e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	43	3.46e-01	0.083000	7.06e-01
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	3.58e-01	0.083000	7.21e-01
RAF ACTIVATION	34	4.03e-01	0.082800	7.51e-01
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	5.33e-01	-0.082600	8.23e-01
PROTEIN FOLDING	87	1.84e-01	0.082500	5.44e-01
REGULATION OF EXPRESSION OF SLITS AND ROBOS	162	7.04e-02	-0.082500	3.55e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	4.44e-01	-0.082100	7.76e-01
RNA POLYMERASE I PROMOTER ESCAPE	48	3.28e-01	-0.081700	6.94e-01
GLUTAMATE AND GLUTAMINE METABOLISM	13	6.11e-01	-0.081600	8.58e-01
BILE ACID AND BILE SALT METABOLISM	25	4.81e-01	-0.081500	7.94e-01
PROTEIN METHYLATION	17	5.61e-01	-0.081500	8.34e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	5.29e-01	-0.081400	8.22e-01
TRANSLESION SYNTHESIS BY POLK	17	5.62e-01	0.081300	8.34e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	90	1.83e-01	-0.081200	5.44e-01
SPHINGOLIPID METABOLISM	79	2.13e-01	-0.081000	5.89e-01
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	5.52e-01	-0.081000	8.32e-01
GAP JUNCTION DEGRADATION	11	6.42e-01	0.080900	8.76e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	5.04e-01	-0.080500	8.07e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	4.62e-01	0.080400	7.88e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	33	4.26e-01	-0.080100	7.66e-01
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	37	4.00e-01	0.079900	7.51e-01
DISEASES OF GLYCOSYLATION	122	1.28e-01	0.079800	4.69e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	4.91e-01	0.079600	8.01e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	67	2.61e-01	-0.079500	6.43e-01
TRANSLATION	287	2.09e-02	-0.079400	2.06e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	6.20e-01	0.079300	8.67e-01
CELLULAR RESPONSE TO HEAT STRESS	96	1.80e-01	-0.079200	5.38e-01
TIE2 SIGNALING	17	5.72e-01	-0.079100	8.38e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	4.25e-01	-0.079000	7.66e-01
DNA STRAND ELONGATION	32	4.42e-01	0.078500	7.76e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	4.89e-01	0.078400	8.01e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	6.00e-01	0.078300	8.53e-01
KILLING MECHANISMS	10	6.69e-01	0.078200	8.86e-01
METABOLISM OF AMINO ACIDS AND DERIVATIVES	311	1.87e-02	-0.077700	1.99e-01
HIV LIFE CYCLE	143	1.10e-01	0.077400	4.37e-01
SELECTIVE AUTOPHAGY	72	2.59e-01	0.076900	6.43e-01
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	32	4.52e-01	-0.076900	7.83e-01
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	14	6.19e-01	-0.076900	8.65e-01
PI METABOLISM	79	2.40e-01	0.076400	6.29e-01
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	5.67e-01	0.075900	8.36e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	60	3.09e-01	-0.075900	6.89e-01
RHOJ GTPASE CYCLE	54	3.36e-01	-0.075700	6.98e-01
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	6.65e-01	-0.075500	8.86e-01
SIGNALING BY ERBB2	48	3.66e-01	-0.075400	7.27e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	5.80e-01	0.075300	8.41e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	2.11e-01	-0.075100	5.85e-01
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	11	6.67e-01	-0.074900	8.86e-01
TRIGLYCERIDE METABOLISM	22	5.44e-01	-0.074800	8.27e-01
CRISTAE FORMATION	31	4.71e-01	-0.074800	7.88e-01
ASPARTATE AND ASPARAGINE METABOLISM	11	6.68e-01	0.074700	8.86e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	3.66e-01	-0.074700	7.27e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	77	2.57e-01	0.074700	6.43e-01
CHROMOSOME MAINTENANCE	103	1.91e-01	-0.074600	5.51e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	58	3.30e-01	0.074000	6.94e-01
BRANCHED CHAIN AMINO ACID CATABOLISM	21	5.60e-01	-0.073500	8.34e-01
TELOMERE MAINTENANCE	79	2.60e-01	-0.073300	6.43e-01
REGULATION OF PTEN GENE TRANSCRIPTION	59	3.30e-01	0.073300	6.94e-01
INSULIN PROCESSING	24	5.36e-01	0.073000	8.25e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	4.63e-01	0.072700	7.88e-01
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	64	3.16e-01	0.072500	6.92e-01
G2 M CHECKPOINTS	135	1.47e-01	-0.072400	4.91e-01
AQUAPORIN MEDIATED TRANSPORT	39	4.36e-01	0.072100	7.74e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS	12	6.66e-01	-0.072000	8.86e-01
TRNA AMINOACYLATION	42	4.20e-01	0.072000	7.60e-01
SYNTHESIS OF PC	26	5.29e-01	-0.071400	8.22e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	34	4.72e-01	-0.071300	7.88e-01
KERATAN SULFATE BIOSYNTHESIS	24	5.46e-01	0.071300	8.28e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	12	6.69e-01	-0.071200	8.86e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	5.31e-01	-0.070900	8.22e-01
CD28 DEPENDENT PI3K AKT SIGNALING	20	5.83e-01	0.070900	8.41e-01
PINK1 PRKN MEDIATED MITOPHAGY	22	5.65e-01	0.070900	8.35e-01
PI3K AKT SIGNALING IN CANCER	89	2.49e-01	-0.070800	6.35e-01
RHOA GTPASE CYCLE	143	1.45e-01	-0.070600	4.91e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	94	2.37e-01	0.070600	6.28e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	3.72e-01	0.070300	7.29e-01
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	5.44e-01	0.070200	8.27e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	6.40e-01	0.069800	8.76e-01
MET PROMOTES CELL MOTILITY	39	4.51e-01	-0.069800	7.83e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	185	1.02e-01	0.069700	4.27e-01
BASE EXCISION REPAIR AP SITE FORMATION	30	5.09e-01	-0.069700	8.09e-01
NICOTINATE METABOLISM	26	5.42e-01	0.069100	8.27e-01
INTERLEUKIN 12 SIGNALING	37	4.68e-01	-0.068900	7.88e-01
TRANSCRIPTION OF THE HIV GENOME	67	3.31e-01	0.068700	6.94e-01
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	1.87e-01	-0.068400	5.48e-01
UB SPECIFIC PROCESSING PROTEASES	168	1.27e-01	-0.068300	4.69e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	4.86e-01	0.068000	7.98e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	83	2.85e-01	0.067900	6.70e-01
SMOOTH MUSCLE CONTRACTION	32	5.07e-01	-0.067800	8.08e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	12	6.85e-01	-0.067600	8.98e-01
RNA POLYMERASE III TRANSCRIPTION	41	4.57e-01	0.067100	7.88e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	3.74e-01	0.067000	7.29e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	13	6.76e-01	-0.066900	8.92e-01
CELLULAR RESPONSE TO STARVATION	146	1.64e-01	-0.066900	5.16e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	33	5.07e-01	-0.066700	8.08e-01
PCP CE PATHWAY	89	2.78e-01	0.066600	6.59e-01
SIGNAL AMPLIFICATION	29	5.38e-01	-0.066000	8.26e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	35	4.99e-01	-0.066000	8.06e-01
DNA DOUBLE STRAND BREAK RESPONSE	53	4.07e-01	-0.065900	7.51e-01
SIGNALING BY WNT IN CANCER	31	5.27e-01	-0.065700	8.22e-01
ASSEMBLY OF THE HIV VIRION	16	6.49e-01	0.065700	8.80e-01
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	7.06e-01	-0.065700	9.09e-01
OXIDATIVE STRESS INDUCED SENESCENCE	79	3.13e-01	-0.065600	6.92e-01
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	3.41e-01	-0.064900	7.02e-01
EPHB MEDIATED FORWARD SIGNALING	42	4.67e-01	0.064800	7.88e-01
CLEC7A DECTIN 1 SIGNALING	93	2.80e-01	-0.064800	6.65e-01
MEMBRANE TRAFFICKING	579	7.95e-03	0.064800	1.26e-01
REGULATION OF BETA CELL DEVELOPMENT	25	5.76e-01	-0.064700	8.40e-01
MRNA SPLICING	188	1.27e-01	0.064600	4.69e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	8.79e-02	0.064400	3.97e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	5.48e-01	0.064400	8.30e-01
DNA REPAIR	295	5.90e-02	0.064000	3.29e-01
G ALPHA I SIGNALLING EVENTS	193	1.26e-01	0.063900	4.69e-01
COPII MEDIATED VESICLE TRANSPORT	65	3.77e-01	0.063400	7.30e-01
HIV INFECTION	222	1.05e-01	0.063200	4.27e-01
COMPLEX I BIOGENESIS	56	4.14e-01	-0.063100	7.55e-01
NOTCH HLH TRANSCRIPTION PATHWAY	28	5.64e-01	-0.063000	8.35e-01
SIGNALING BY WNT	267	7.82e-02	-0.062700	3.69e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	85	3.19e-01	0.062600	6.92e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	11	7.20e-01	-0.062500	9.15e-01
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	5.83e-01	0.062200	8.41e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	105	2.73e-01	-0.061900	6.55e-01
RHOD GTPASE CYCLE	49	4.54e-01	0.061800	7.84e-01
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	4.85e-01	-0.061500	7.98e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	5.54e-01	-0.061500	8.32e-01
RND3 GTPASE CYCLE	38	5.16e-01	-0.060900	8.16e-01
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	6.30e-01	0.060800	8.71e-01
COSTIMULATION BY THE CD28 FAMILY	49	4.62e-01	-0.060800	7.88e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	20	6.40e-01	0.060400	8.76e-01
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	27	5.89e-01	-0.060100	8.46e-01
COLLAGEN CHAIN TRIMERIZATION	39	5.17e-01	0.060000	8.16e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	4.72e-01	-0.060000	7.88e-01
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	7.32e-01	0.059700	9.23e-01
RAB REGULATION OF TRAFFICKING	117	2.66e-01	0.059600	6.48e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	109	2.83e-01	0.059600	6.69e-01
BETA CATENIN PHOSPHORYLATION CASCADE	16	6.80e-01	0.059600	8.93e-01
ACYL CHAIN REMODELLING OF PE	16	6.80e-01	0.059500	8.93e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	7.01e-01	0.059200	9.07e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	5.82e-01	-0.059100	8.41e-01
HDMS DEMETHYLATE HISTONES	28	5.89e-01	-0.059000	8.46e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	7.36e-01	0.058800	9.24e-01
CARGO CONCENTRATION IN THE ER	30	5.78e-01	-0.058700	8.41e-01
ARACHIDONIC ACID METABOLISM	38	5.32e-01	-0.058600	8.22e-01
MITOTIC G2 G2 M PHASES	184	1.73e-01	0.058300	5.31e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	94	3.30e-01	-0.058200	6.94e-01
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	5.19e-01	-0.058200	8.17e-01
FANCONI ANEMIA PATHWAY	36	5.47e-01	0.058000	8.29e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	7.28e-01	0.058000	9.20e-01
RESPIRATORY ELECTRON TRANSPORT	102	3.13e-01	-0.057900	6.92e-01
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	6.32e-01	0.057600	8.71e-01
HATS ACETYLATE HISTONES	93	3.38e-01	0.057500	7.00e-01
SIGNALING BY FGFR IN DISEASE	55	4.62e-01	-0.057300	7.88e-01
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	6.14e-01	-0.057200	8.61e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	25	6.23e-01	0.056800	8.67e-01
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	7.46e-01	0.056400	9.25e-01
INSULIN RECEPTOR SIGNALLING CASCADE	42	5.28e-01	-0.056400	8.22e-01
DEUBIQUITINATION	242	1.33e-01	-0.056200	4.75e-01
TCR SIGNALING	100	3.34e-01	-0.055900	6.97e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	5.46e-01	0.055900	8.28e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	51	4.93e-01	0.055500	8.01e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	37	5.60e-01	0.055400	8.34e-01
DISEASES OF MITOTIC CELL CYCLE	37	5.62e-01	0.055100	8.34e-01
SIGNALING BY ERYTHROPOIETIN	24	6.41e-01	-0.055000	8.76e-01
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	74	4.15e-01	0.054800	7.55e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	34	5.81e-01	-0.054700	8.41e-01
VESICLE MEDIATED TRANSPORT	609	2.19e-02	0.054600	2.10e-01
CITRIC ACID CYCLE TCA CYCLE	22	6.58e-01	0.054600	8.86e-01
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	13	7.34e-01	-0.054500	9.24e-01
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	24	6.45e-01	0.054300	8.77e-01
RHO GTPASES ACTIVATE PAKS	21	6.68e-01	0.054100	8.86e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	3.60e-01	0.054100	7.24e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	5.31e-01	-0.054100	8.22e-01
OTHER SEMAPHORIN INTERACTIONS	19	6.86e-01	-0.053700	8.98e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	12	7.50e-01	-0.053100	9.27e-01
INOSITOL PHOSPHATE METABOLISM	47	5.29e-01	0.053100	8.22e-01
PLATELET AGGREGATION PLUG FORMATION	33	5.99e-01	-0.052900	8.53e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	6.41e-01	0.052800	8.76e-01
RESOLUTION OF D LOOP STRUCTURES	31	6.11e-01	-0.052800	8.58e-01
INTERLEUKIN 1 FAMILY SIGNALING	123	3.15e-01	-0.052500	6.92e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	6.09e-01	-0.052300	8.57e-01
PKA MEDIATED PHOSPHORYLATION OF CREB	19	6.94e-01	0.052200	9.04e-01
SIGNALING BY GPCR	475	5.25e-02	0.052100	3.09e-01
SIGNALING BY ROBO RECEPTORS	207	1.99e-01	-0.051800	5.64e-01
GLUCAGON TYPE LIGAND RECEPTORS	24	6.61e-01	0.051700	8.86e-01
HYALURONAN UPTAKE AND DEGRADATION	11	7.67e-01	0.051700	9.39e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	94	3.87e-01	-0.051600	7.42e-01
G1 S DNA DAMAGE CHECKPOINTS	65	4.72e-01	-0.051600	7.88e-01
INTERLEUKIN 2 FAMILY SIGNALING	34	6.03e-01	-0.051500	8.54e-01
VISUAL PHOTOTRANSDUCTION	61	4.87e-01	-0.051500	7.98e-01
IRON UPTAKE AND TRANSPORT	52	5.22e-01	-0.051300	8.19e-01
CA2 PATHWAY	55	5.14e-01	-0.050900	8.15e-01
POLYMERASE SWITCHING	14	7.42e-01	0.050800	9.25e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	5.71e-01	0.050600	8.38e-01
CELLULAR SENESCENCE	143	2.98e-01	-0.050500	6.78e-01
OTHER INTERLEUKIN SIGNALING	20	6.99e-01	0.050000	9.06e-01
HOMOLOGY DIRECTED REPAIR	110	3.69e-01	-0.049600	7.29e-01
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	6.02e-01	0.049600	8.54e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	91	4.15e-01	0.049500	7.55e-01
RMTS METHYLATE HISTONE ARGININES	44	5.71e-01	-0.049300	8.38e-01
RAS PROCESSING	24	6.77e-01	-0.049100	8.92e-01
HEDGEHOG ON STATE	82	4.43e-01	-0.049000	7.76e-01
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	7.43e-01	0.048900	9.25e-01
GLYCOSPHINGOLIPID METABOLISM	38	6.02e-01	0.048900	8.54e-01
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	2.70e-01	-0.048800	6.52e-01
LDL CLEARANCE	16	7.37e-01	0.048600	9.24e-01
STIMULI SENSING CHANNELS	75	4.71e-01	0.048200	7.88e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	103	4.02e-01	0.047800	7.51e-01
RAC1 GTPASE CYCLE	177	2.77e-01	-0.047400	6.59e-01
GENE SILENCING BY RNA	87	4.47e-01	-0.047200	7.79e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	6.77e-01	0.047200	8.92e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	56	5.43e-01	-0.047000	8.27e-01
SIGNALING BY FGFR2 IN DISEASE	36	6.27e-01	-0.046800	8.69e-01
DEGRADATION OF THE EXTRACELLULAR MATRIX	106	4.05e-01	0.046800	7.51e-01
SIGNALING BY NOTCH	189	2.68e-01	-0.046800	6.51e-01
METABOLISM OF NUCLEOTIDES	92	4.38e-01	0.046800	7.74e-01
PHOSPHOLIPID METABOLISM	187	2.71e-01	0.046800	6.52e-01
BASE EXCISION REPAIR	58	5.38e-01	0.046700	8.26e-01
POLO LIKE KINASE MEDIATED EVENTS	14	7.62e-01	0.046700	9.37e-01
TRP CHANNELS	19	7.26e-01	-0.046500	9.18e-01
REGULATION OF SIGNALING BY CBL	22	7.06e-01	-0.046500	9.09e-01
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	7.72e-01	0.046500	9.43e-01
CELLULAR RESPONSES TO EXTERNAL STIMULI	601	5.38e-02	-0.046200	3.10e-01
ONCOGENIC MAPK SIGNALING	77	4.83e-01	0.046200	7.96e-01
SIGNALLING TO ERKS	33	6.47e-01	-0.046000	8.79e-01
CILIUM ASSEMBLY	189	2.76e-01	0.046000	6.59e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	177	2.92e-01	-0.046000	6.76e-01
METABOLISM OF RNA	645	4.75e-02	0.045900	2.99e-01
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	82	4.73e-01	0.045900	7.88e-01
MITOCHONDRIAL PROTEIN IMPORT	63	5.30e-01	0.045800	8.22e-01
TNFR2 NON CANONICAL NF KB PATHWAY	79	4.82e-01	-0.045700	7.96e-01
G BETA GAMMA SIGNALLING THROUGH CDC42	18	7.39e-01	0.045300	9.25e-01
DEGRADATION OF DVL	55	5.62e-01	0.045200	8.34e-01
FC EPSILON RECEPTOR FCERI SIGNALING	122	3.92e-01	-0.044900	7.45e-01
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	7.22e-01	0.044900	9.16e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	7.98e-01	-0.044500	9.58e-01
RHO GTPASE CYCLE	426	1.17e-01	-0.044400	4.54e-01
G ALPHA 12 13 SIGNALLING EVENTS	75	5.06e-01	0.044400	8.08e-01
ONCOGENE INDUCED SENESCENCE	32	6.64e-01	-0.044400	8.86e-01
TRANSCRIPTIONAL REGULATION BY TP53	342	1.62e-01	0.044100	5.15e-01
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	65	5.44e-01	-0.043600	8.27e-01
PROLONGED ERK ACTIVATION EVENTS	14	7.79e-01	0.043400	9.47e-01
MITOTIC METAPHASE AND ANAPHASE	208	2.85e-01	0.043100	6.70e-01
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	4.90e-01	0.043100	8.01e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	281	2.15e-01	0.043000	5.91e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	7.46e-01	-0.043000	9.25e-01
HOST INTERACTIONS OF HIV FACTORS	126	4.06e-01	0.042900	7.51e-01
PLASMA LIPOPROTEIN CLEARANCE	27	7.01e-01	0.042800	9.07e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	95	4.73e-01	0.042600	7.88e-01
METABOLISM OF STEROIDS	112	4.38e-01	-0.042500	7.74e-01
PRE NOTCH PROCESSING IN GOLGI	17	7.62e-01	0.042400	9.37e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	5.72e-01	0.042200	8.38e-01
CYTOSOLIC TRNA AMINOACYLATION	24	7.20e-01	0.042200	9.15e-01
TRANSPORT OF SMALL MOLECULES	566	8.90e-02	0.042000	3.97e-01
G ALPHA Z SIGNALLING EVENTS	45	6.28e-01	0.041800	8.69e-01
NERVOUS SYSTEM DEVELOPMENT	545	1.01e-01	0.041200	4.26e-01
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	6.23e-01	-0.041000	8.67e-01
DISEASES OF METABOLISM	197	3.23e-01	0.040900	6.93e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	19	7.58e-01	0.040900	9.35e-01
REGULATION OF TP53 ACTIVITY	151	3.89e-01	0.040700	7.42e-01
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	82	5.25e-01	0.040600	8.22e-01
GABA B RECEPTOR ACTIVATION	39	6.61e-01	0.040600	8.86e-01
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	23	7.36e-01	-0.040600	9.24e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	37	6.70e-01	-0.040400	8.86e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	49	6.25e-01	-0.040300	8.68e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	366	1.87e-01	-0.040300	5.48e-01
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	5.93e-01	-0.040300	8.47e-01
HEDGEHOG LIGAND BIOGENESIS	61	5.90e-01	-0.039900	8.46e-01
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	7.85e-01	-0.039300	9.51e-01
SIGNALING BY KIT IN DISEASE	20	7.61e-01	-0.039200	9.37e-01
MITOTIC PROMETAPHASE	178	3.71e-01	0.038900	7.29e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	8.23e-01	-0.038900	9.65e-01
SIGNALING BY FGFR4	32	7.06e-01	-0.038600	9.09e-01
FGFR2 MUTANT RECEPTOR ACTIVATION	26	7.34e-01	0.038400	9.24e-01
PERK REGULATES GENE EXPRESSION	28	7.26e-01	-0.038300	9.18e-01
ACTIVATION OF RAC1	13	8.11e-01	-0.038300	9.62e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	62	6.04e-01	-0.038100	8.54e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	24	7.47e-01	-0.038100	9.25e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	74	5.73e-01	0.037900	8.38e-01
SLC TRANSPORTER DISORDERS	68	5.92e-01	0.037600	8.47e-01
SIALIC ACID METABOLISM	32	7.14e-01	0.037500	9.12e-01
O LINKED GLYCOSYLATION OF MUCINS	41	6.78e-01	0.037400	8.92e-01
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	7.96e-01	0.037400	9.57e-01
DEVELOPMENTAL BIOLOGY	808	7.78e-02	0.036700	3.68e-01
M PHASE	342	2.47e-01	0.036500	6.35e-01
MITOCHONDRIAL BIOGENESIS	92	5.51e-01	0.036000	8.32e-01
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	8.05e-01	0.035600	9.61e-01
CELL CELL JUNCTION ORGANIZATION	48	6.70e-01	-0.035600	8.86e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	63	6.26e-01	-0.035500	8.68e-01
METABOLISM OF FOLATE AND PTERINES	15	8.12e-01	0.035500	9.62e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	94	5.55e-01	0.035300	8.32e-01
CELL CYCLE CHECKPOINTS	245	3.48e-01	-0.034800	7.09e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	7.50e-01	0.034800	9.27e-01
SENSORY PERCEPTION	151	4.64e-01	-0.034500	7.88e-01
MITOCHONDRIAL TRANSLATION	93	5.65e-01	-0.034500	8.35e-01
GABA RECEPTOR ACTIVATION	53	6.64e-01	-0.034500	8.86e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	8.36e-01	0.034500	9.70e-01
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	8.30e-01	-0.034300	9.69e-01
SIGNALING BY NOTCH1	75	6.09e-01	-0.034200	8.57e-01
METABOLISM OF POLYAMINES	57	6.62e-01	0.033500	8.86e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	45	6.98e-01	0.033500	9.06e-01
APOPTOSIS	164	4.63e-01	-0.033300	7.88e-01
INTERLEUKIN 17 SIGNALING	66	6.41e-01	0.033200	8.76e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	6.21e-01	0.033200	8.67e-01
FLT3 SIGNALING IN DISEASE	27	7.66e-01	-0.033100	9.39e-01
SARS COV INFECTIONS	140	5.00e-01	0.033000	8.06e-01
TP53 REGULATES METABOLIC GENES	85	6.01e-01	-0.032800	8.54e-01
PREGNENOLONE BIOSYNTHESIS	12	8.44e-01	-0.032800	9.71e-01
EXTRACELLULAR MATRIX ORGANIZATION	241	3.88e-01	-0.032300	7.42e-01
GLUTATHIONE CONJUGATION	29	7.64e-01	-0.032200	9.38e-01
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	66	6.53e-01	0.032100	8.81e-01
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	137	5.20e-01	0.031900	8.17e-01
HCMV INFECTION	104	5.75e-01	0.031800	8.40e-01
CTLA4 INHIBITORY SIGNALING	20	8.07e-01	-0.031600	9.62e-01
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	70	6.50e-01	0.031400	8.80e-01
RORA ACTIVATES GENE EXPRESSION	18	8.18e-01	-0.031300	9.64e-01
MYOGENESIS	24	7.91e-01	0.031300	9.54e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	6.97e-01	0.031200	9.06e-01
SIGNALING BY MET	75	6.44e-01	-0.030800	8.77e-01
DEATH RECEPTOR SIGNALLING	134	5.38e-01	0.030800	8.26e-01
RND2 GTPASE CYCLE	38	7.43e-01	-0.030800	9.25e-01
SIGNALING BY EGFR	47	7.16e-01	-0.030700	9.14e-01
THE PHOTOTRANSDUCTION CASCADE	21	8.08e-01	0.030600	9.62e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	8.27e-01	0.030600	9.66e-01
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	21	8.09e-01	0.030500	9.62e-01
CELL CELL COMMUNICATION	105	5.91e-01	-0.030400	8.46e-01
METABOLISM OF STEROID HORMONES	20	8.14e-01	-0.030400	9.62e-01
STABILIZATION OF P53	54	7.03e-01	-0.030000	9.08e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	8.63e-01	-0.030000	9.76e-01
DNA REPLICATION	122	5.69e-01	0.029900	8.38e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	7.83e-01	0.029600	9.49e-01
HIV TRANSCRIPTION INITIATION	45	7.32e-01	0.029500	9.23e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	7.13e-01	0.029500	9.12e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	20	8.23e-01	0.029000	9.65e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	8.47e-01	0.028900	9.72e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	8.69e-01	-0.028700	9.78e-01
TELOMERE C STRAND SYNTHESIS INITIATION	13	8.58e-01	0.028700	9.73e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	7.80e-01	-0.028500	9.48e-01
GAP JUNCTION ASSEMBLY	21	8.22e-01	-0.028400	9.65e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1210	9.90e-02	0.028400	4.19e-01
RHO GTPASES ACTIVATE FORMINS	119	5.94e-01	0.028300	8.47e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	17	8.40e-01	-0.028300	9.70e-01
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	59	7.08e-01	0.028300	9.10e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	22	8.19e-01	-0.028100	9.64e-01
PTEN REGULATION	134	5.76e-01	0.028000	8.40e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	13	8.62e-01	0.027800	9.76e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	8.52e-01	0.027800	9.72e-01
CD28 DEPENDENT VAV1 PATHWAY	11	8.74e-01	-0.027700	9.78e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	222	4.78e-01	-0.027700	7.92e-01
PEPTIDE HORMONE METABOLISM	59	7.13e-01	-0.027700	9.12e-01
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	6.63e-01	0.027500	8.86e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	10	8.81e-01	0.027400	9.78e-01
REGULATION OF KIT SIGNALING	16	8.50e-01	-0.027300	9.72e-01
CIRCADIAN CLOCK	68	6.98e-01	0.027200	9.06e-01
PECAM1 INTERACTIONS	12	8.71e-01	-0.027100	9.78e-01
KINESINS	48	7.47e-01	0.026900	9.25e-01
MAPK FAMILY SIGNALING CASCADES	288	4.38e-01	0.026600	7.74e-01
PROCESSING AND ACTIVATION OF SUMO	10	8.85e-01	0.026400	9.78e-01
INTERLEUKIN 1 SIGNALING	95	6.58e-01	-0.026300	8.86e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	34	7.91e-01	0.026300	9.54e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	109	6.36e-01	0.026200	8.76e-01
HEDGEHOG OFF STATE	106	6.41e-01	0.026200	8.76e-01
SIGNALING BY LEPTIN	10	8.86e-01	-0.026100	9.78e-01
ADHERENS JUNCTIONS INTERACTIONS	30	8.05e-01	0.026100	9.61e-01
ABC TRANSPORTER DISORDERS	69	7.09e-01	0.026000	9.10e-01
SIGNALING BY THE B CELL RECEPTOR BCR	103	6.51e-01	-0.025800	8.80e-01
DNA REPLICATION PRE INITIATION	80	6.91e-01	0.025700	9.03e-01
O LINKED GLYCOSYLATION	83	6.89e-01	0.025400	9.01e-01
HCMV EARLY EVENTS	81	6.94e-01	-0.025300	9.04e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	7.10e-01	0.025200	9.10e-01
PLASMA LIPOPROTEIN ASSEMBLY	13	8.75e-01	-0.025200	9.78e-01
ELASTIC FIBRE FORMATION	37	7.93e-01	-0.025000	9.54e-01
SIGNALING BY FGFR1	43	7.82e-01	-0.024400	9.49e-01
LAGGING STRAND SYNTHESIS	20	8.52e-01	-0.024000	9.72e-01
PHASE II CONJUGATION OF COMPOUNDS	62	7.44e-01	-0.024000	9.25e-01
FERTILIZATION	10	8.96e-01	-0.023900	9.78e-01
TRIGLYCERIDE CATABOLISM	14	8.77e-01	-0.023900	9.78e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	282	4.94e-01	0.023700	8.01e-01
FGFR2 ALTERNATIVE SPLICING	25	8.37e-01	0.023700	9.70e-01
DNA DOUBLE STRAND BREAK REPAIR	139	6.32e-01	-0.023600	8.71e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	27	8.33e-01	0.023400	9.69e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	8.80e-01	-0.023300	9.78e-01
COLLAGEN FORMATION	77	7.24e-01	0.023300	9.18e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	344	4.64e-01	0.023000	7.88e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	8.20e-01	0.023000	9.64e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	68	7.44e-01	0.022900	9.25e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	8.16e-01	-0.022800	9.62e-01
CYTOPROTECTION BY HMOX1	119	6.69e-01	0.022700	8.86e-01
SIGNALING BY VEGF	101	6.94e-01	-0.022700	9.04e-01
PEROXISOMAL LIPID METABOLISM	26	8.42e-01	-0.022600	9.71e-01
PROGRAMMED CELL DEATH	186	6.05e-01	-0.022000	8.55e-01
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	7.76e-01	-0.022000	9.46e-01
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	26	8.47e-01	-0.021900	9.72e-01
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	8.04e-01	-0.021900	9.61e-01
INFECTIOUS DISEASE	734	3.17e-01	-0.021800	6.92e-01
CHEMOKINE RECEPTORS BIND CHEMOKINES	13	8.92e-01	0.021700	9.78e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	9.06e-01	-0.021700	9.81e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	8.43e-01	-0.021600	9.71e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	8.81e-01	0.021600	9.78e-01
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	8.58e-01	0.021600	9.73e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	137	6.64e-01	0.021500	8.86e-01
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	8.94e-01	-0.021400	9.78e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	31	8.37e-01	0.021400	9.70e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	8.64e-01	-0.021100	9.76e-01
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	8.96e-01	0.020800	9.78e-01
SIGNALING BY FGFR2	62	7.78e-01	0.020700	9.47e-01
PYRUVATE METABOLISM	27	8.54e-01	-0.020400	9.72e-01
G PROTEIN ACTIVATION	21	8.73e-01	0.020200	9.78e-01
CELL CYCLE MITOTIC	477	4.58e-01	0.019900	7.88e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	630	3.98e-01	-0.019800	7.51e-01
SIGNALING BY FGFR3	35	8.40e-01	-0.019700	9.70e-01
PLASMA LIPOPROTEIN REMODELING	16	8.91e-01	0.019700	9.78e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	92	7.45e-01	-0.019600	9.25e-01
SEMAPHORIN INTERACTIONS	64	7.87e-01	-0.019500	9.53e-01
G1 S SPECIFIC TRANSCRIPTION	26	8.64e-01	-0.019400	9.76e-01
FCERI MEDIATED NF KB ACTIVATION	76	7.71e-01	-0.019300	9.42e-01
MITOTIC SPINDLE CHECKPOINT	98	7.42e-01	0.019300	9.25e-01
MAPK6 MAPK4 SIGNALING	83	7.68e-01	-0.018700	9.40e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	8.53e-01	0.018700	9.72e-01
METABOLISM OF FAT SOLUBLE VITAMINS	33	8.54e-01	-0.018600	9.72e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	14	9.05e-01	0.018400	9.81e-01
CHROMATIN MODIFYING ENZYMES	219	6.45e-01	0.018100	8.77e-01
NUCLEOBASE BIOSYNTHESIS	15	9.04e-01	-0.018000	9.81e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	22	8.85e-01	-0.017800	9.78e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	9.23e-01	-0.017700	9.87e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	31	8.65e-01	-0.017600	9.76e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	61	8.12e-01	0.017600	9.62e-01
CELL CYCLE	595	4.68e-01	0.017500	7.88e-01
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	7.74e-01	-0.017400	9.44e-01
CELLULAR RESPONSE TO HYPOXIA	71	8.00e-01	-0.017400	9.59e-01
HEMOSTASIS	474	5.19e-01	-0.017400	8.17e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	8.94e-01	-0.017300	9.78e-01
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	9.26e-01	0.016900	9.87e-01
PYROPTOSIS	21	8.94e-01	-0.016700	9.78e-01
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	8.90e-01	-0.016600	9.78e-01
UNFOLDED PROTEIN RESPONSE UPR	85	7.92e-01	-0.016600	9.54e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	16	9.10e-01	-0.016400	9.81e-01
SUMOYLATION	163	7.19e-01	-0.016300	9.15e-01
SEPARATION OF SISTER CHROMATIDS	167	7.19e-01	0.016100	9.15e-01
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	9.15e-01	0.016000	9.84e-01
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	8.95e-01	0.015800	9.78e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	60	8.33e-01	0.015700	9.69e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	9.32e-01	0.015500	9.87e-01
UCH PROTEINASES	89	8.02e-01	-0.015400	9.60e-01
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	8.14e-01	0.015400	9.62e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	26	8.94e-01	0.015100	9.78e-01
RAB GERANYLGERANYLATION	58	8.44e-01	0.014900	9.71e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	43	8.66e-01	-0.014900	9.76e-01
DOWNSTREAM SIGNAL TRANSDUCTION	29	8.91e-01	-0.014700	9.78e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	9.27e-01	-0.014600	9.87e-01
EPHRIN SIGNALING	19	9.12e-01	0.014600	9.82e-01
NEGATIVE REGULATION OF MET ACTIVITY	21	9.08e-01	-0.014600	9.81e-01
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	58	8.49e-01	0.014500	9.72e-01
FLT3 SIGNALING	36	8.81e-01	0.014400	9.78e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	27	8.97e-01	-0.014400	9.78e-01
POTENTIAL THERAPEUTICS FOR SARS	77	8.30e-01	-0.014200	9.69e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	9.34e-01	-0.013900	9.87e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	9.35e-01	0.013700	9.87e-01
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	8.53e-01	0.013600	9.72e-01
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	8.74e-01	-0.013500	9.78e-01
METABOLISM OF LIPIDS	611	5.72e-01	-0.013400	8.38e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	9.01e-01	-0.013300	9.81e-01
ORC1 REMOVAL FROM CHROMATIN	67	8.54e-01	0.013000	9.72e-01
SIGNALING BY INSULIN RECEPTOR	61	8.63e-01	0.012800	9.76e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	119	8.13e-01	0.012600	9.62e-01
METABOLISM OF VITAMINS AND COFACTORS	153	7.89e-01	0.012600	9.53e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	9.18e-01	-0.012400	9.86e-01
PEPTIDE LIGAND BINDING RECEPTORS	105	8.26e-01	-0.012400	9.66e-01
TRANSCRIPTIONAL REGULATION BY RUNX2	108	8.27e-01	-0.012200	9.66e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	15	9.37e-01	0.011800	9.87e-01
RHOU GTPASE CYCLE	33	9.08e-01	0.011600	9.81e-01
SIGNALING BY NODAL	15	9.39e-01	-0.011500	9.87e-01
SIGNALING BY NOTCH4	83	8.57e-01	0.011400	9.73e-01
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	8.88e-01	0.011400	9.78e-01
MITOTIC G1 PHASE AND G1 S TRANSITION	142	8.16e-01	-0.011300	9.62e-01
REGULATION OF TNFR1 SIGNALING	34	9.10e-01	0.011200	9.81e-01
METAL ION SLC TRANSPORTERS	24	9.25e-01	-0.011200	9.87e-01
RHO GTPASE EFFECTORS	249	7.62e-01	0.011200	9.37e-01
SIGNALING BY FGFR2 IIIA TM	19	9.33e-01	0.011200	9.87e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	180	7.97e-01	-0.011100	9.58e-01
IRE1ALPHA ACTIVATES CHAPERONES	49	8.94e-01	0.011000	9.78e-01
FOXO MEDIATED TRANSCRIPTION	58	8.87e-01	-0.010700	9.78e-01
GLUTATHIONE SYNTHESIS AND RECYCLING	11	9.52e-01	-0.010400	9.87e-01
SIGNALING BY HEDGEHOG	141	8.32e-01	-0.010300	9.69e-01
ACTIVATION OF SMO	16	9.44e-01	-0.010200	9.87e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	88	8.69e-01	-0.010200	9.78e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	180	8.15e-01	0.010100	9.62e-01
ECM PROTEOGLYCANS	63	8.90e-01	0.010100	9.78e-01
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	68	8.86e-01	0.010100	9.78e-01
MISMATCH REPAIR	15	9.47e-01	0.009830	9.87e-01
DEGRADATION OF GLI1 BY THE PROTEASOME	57	9.01e-01	-0.009500	9.81e-01
PROTEIN LOCALIZATION	157	8.38e-01	0.009440	9.70e-01
RHOV GTPASE CYCLE	32	9.28e-01	-0.009280	9.87e-01
CHOLESTEROL BIOSYNTHESIS	24	9.39e-01	0.009100	9.87e-01
ADAPTIVE IMMUNE SYSTEM	600	7.10e-01	0.008940	9.10e-01
RHO GTPASES ACTIVATE CIT	18	9.48e-01	0.008830	9.87e-01
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	9.07e-01	-0.008810	9.81e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	9.48e-01	-0.008700	9.87e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	64	9.06e-01	-0.008550	9.81e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	9.22e-01	-0.008530	9.87e-01
MICRORNA MIRNA BIOGENESIS	24	9.44e-01	-0.008320	9.87e-01
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	117	8.79e-01	-0.008170	9.78e-01
ENDOGENOUS STEROLS	21	9.49e-01	-0.008110	9.87e-01
COLLAGEN DEGRADATION	50	9.24e-01	0.007800	9.87e-01
TNF SIGNALING	43	9.32e-01	0.007550	9.87e-01
GPCR LIGAND BINDING	260	8.35e-01	0.007520	9.70e-01
NGF STIMULATED TRANSCRIPTION	37	9.43e-01	-0.006840	9.87e-01
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	30	9.49e-01	-0.006800	9.87e-01
P75NTR REGULATES AXONOGENESIS	10	9.71e-01	0.006710	9.92e-01
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	13	9.69e-01	-0.006290	9.92e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	9.47e-01	-0.006260	9.87e-01
SIGNALING BY PDGF	53	9.38e-01	-0.006220	9.87e-01
RHO GTPASES ACTIVATE ROCKS	19	9.64e-01	-0.005940	9.92e-01
REGULATION OF PTEN STABILITY AND ACTIVITY	66	9.34e-01	-0.005880	9.87e-01
G PROTEIN BETA GAMMA SIGNALLING	30	9.56e-01	0.005800	9.90e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	9.51e-01	0.005790	9.87e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	9.69e-01	-0.005770	9.92e-01
TRANS GOLGI NETWORK VESICLE BUDDING	70	9.34e-01	0.005690	9.87e-01
MET ACTIVATES PTK2 SIGNALING	29	9.58e-01	-0.005630	9.91e-01
MITOTIC PROPHASE	95	9.26e-01	-0.005550	9.87e-01
CD28 CO STIMULATION	30	9.59e-01	0.005450	9.91e-01
RRNA PROCESSING	195	8.96e-01	-0.005420	9.78e-01
CELLULAR RESPONSE TO CHEMICAL STRESS	149	9.10e-01	-0.005350	9.81e-01
INTERLEUKIN 15 SIGNALING	13	9.74e-01	-0.005260	9.92e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	103	9.27e-01	-0.005230	9.87e-01
PROCESSING OF SMDT1	16	9.72e-01	-0.005040	9.92e-01
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	9.51e-01	0.004870	9.87e-01
SUMOYLATION OF INTRACELLULAR RECEPTORS	26	9.68e-01	-0.004530	9.92e-01
REGULATION OF RAS BY GAPS	66	9.51e-01	0.004420	9.87e-01
HCMV LATE EVENTS	66	9.51e-01	-0.004390	9.87e-01
SIGNALING BY NOTCH2	33	9.66e-01	0.004320	9.92e-01
MATURATION OF NUCLEOPROTEIN	10	9.81e-01	-0.004280	9.92e-01
CDC42 GTPASE CYCLE	153	9.31e-01	0.004080	9.87e-01
S PHASE	154	9.32e-01	0.003990	9.87e-01
BIOLOGICAL OXIDATIONS	125	9.41e-01	0.003840	9.87e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	9.82e-01	-0.003800	9.92e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	9.76e-01	0.003690	9.92e-01
SIGNALING BY NOTCH3	48	9.65e-01	0.003620	9.92e-01
REGULATION OF BACH1 ACTIVITY	11	9.84e-01	0.003570	9.92e-01
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	9.78e-01	-0.003440	9.92e-01
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	9.64e-01	-0.003270	9.92e-01
SEMA3A PAK DEPENDENT AXON REPULSION	16	9.82e-01	-0.003240	9.92e-01
LEISHMANIA INFECTION	197	9.38e-01	-0.003210	9.87e-01
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	84	9.63e-01	-0.002950	9.92e-01
RNA POLYMERASE II TRANSCRIPTION	1088	8.71e-01	-0.002950	9.78e-01
G ALPHA Q SIGNALLING EVENTS	154	9.50e-01	0.002940	9.87e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	22	9.81e-01	-0.002920	9.92e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	458	9.17e-01	0.002850	9.86e-01
SIGNALING BY FGFR	72	9.69e-01	0.002680	9.92e-01
RAC3 GTPASE CYCLE	88	9.66e-01	0.002620	9.92e-01
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	9.84e-01	-0.002580	9.92e-01
TELOMERE EXTENSION BY TELOMERASE	22	9.84e-01	0.002470	9.92e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	10	9.90e-01	0.002220	9.93e-01
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	9.73e-01	0.002200	9.92e-01
EXTENSION OF TELOMERES	49	9.79e-01	-0.002130	9.92e-01
MAP2K AND MAPK ACTIVATION	36	9.83e-01	0.002110	9.92e-01
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	9.91e-01	0.001680	9.93e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	55	9.83e-01	0.001630	9.92e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	41	9.86e-01	0.001620	9.92e-01
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	9.85e-01	-0.001490	9.92e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	9.94e-01	-0.001460	9.94e-01
RHOB GTPASE CYCLE	67	9.84e-01	0.001420	9.92e-01
SYNTHESIS OF PA	29	9.90e-01	0.001360	9.93e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	9.84e-01	0.001280	9.92e-01
RNA POLYMERASE I TRANSCRIPTION	68	9.86e-01	-0.001240	9.92e-01
DEGRADATION OF AXIN	53	9.88e-01	0.001180	9.92e-01
RESOLUTION OF SISTER CHROMATID COHESION	103	9.87e-01	-0.000917	9.92e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	10	9.98e-01	-0.000388	9.98e-01

Detailed Gene set reports

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
	784
set	REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
setSize	10
pANOVA	0.00196
s.dist	0.566
p.adjustANOVA	0.0528

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nell2	8334
Slit2	7715
Slit3	7397
Robo2	6798
Ntn1	4776
Src	4689
Robo3	4576
Slit1	4244
Robo1	-190
Dcc	-470

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All member genes
GeneID	Gene Rank
Nell2	8334
Slit2	7715
Slit3	7397
Robo2	6798
Ntn1	4776
Src	4689
Robo3	4576
Slit1	4244
Robo1	-190
Dcc	-470

TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS

TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS
	1095
set	TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS
setSize	17
pANOVA	7.94e-05
s.dist	0.553
p.adjustANOVA	0.00924

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkca	8091
Prkcg	7934
Ap2a1	7394
Nsf	7135
Ap2b1	7080
Prkcb	6741
Ap2a2	6358
Gria3	6301
Pick1	5747
Ap2m1	5729
Gria1	5278
Grip1	4534
Gria2	3969
Ap2s1	2536
Tspan7	1433
Gria4	120
Grip2	-6880

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkca	8091
Prkcg	7934
Ap2a1	7394
Nsf	7135
Ap2b1	7080
Prkcb	6741
Ap2a2	6358
Gria3	6301
Pick1	5747
Ap2m1	5729
Gria1	5278
Grip1	4534
Gria2	3969
Ap2s1	2536
Tspan7	1433
Gria4	120
Grip2	-6880

SYNAPTIC ADHESION LIKE MOLECULES

SYNAPTIC ADHESION LIKE MOLECULES
	1022
set	SYNAPTIC ADHESION LIKE MOLECULES
setSize	21
pANOVA	3.89e-05
s.dist	0.519
p.adjustANOVA	0.00503

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Lrfn4	7994
Ptprs	7795
Grin1	7629
Dlg3	7480
Grin2c	7110
Dlg4	6940
Gria3	6301
Lrfn2	6283
Grin2b	6241
Lrfn1	5481
Gria1	5278
Grin2a	4615
Flot1	3791
Lrfn3	3175
Ptprf	2822
Flot2	2657
Rtn3	2122
Ptprd	278
Gria4	120
Dlg1	61

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Lrfn4	7994
Ptprs	7795
Grin1	7629
Dlg3	7480
Grin2c	7110
Dlg4	6940
Gria3	6301
Lrfn2	6283
Grin2b	6241
Lrfn1	5481
Gria1	5278
Grin2a	4615
Flot1	3791
Lrfn3	3175
Ptprf	2822
Flot2	2657
Rtn3	2122
Ptprd	278
Gria4	120
Dlg1	61
Grin2d	-2102

COMMON PATHWAY OF FIBRIN CLOT FORMATION

COMMON PATHWAY OF FIBRIN CLOT FORMATION
	167
set	COMMON PATHWAY OF FIBRIN CLOT FORMATION
setSize	11
pANOVA	0.00323
s.dist	-0.513
p.adjustANOVA	0.0767

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Serpine2	-7671
Procr	-7567
Pros1	-6994
Serpind1	-6322
F8	-6292
F2r	-5645
F13a1	-3810
Serpinc1	-3407
Prtn3	-1921
F5	495
Thbd	974

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Serpine2	-7671
Procr	-7567
Pros1	-6994
Serpind1	-6322
F8	-6292
F2r	-5645
F13a1	-3810
Serpinc1	-3407
Prtn3	-1921
F5	495
Thbd	974

WNT5A DEPENDENT INTERNALIZATION OF FZD4

WNT5A DEPENDENT INTERNALIZATION OF FZD4
	1161
set	WNT5A DEPENDENT INTERNALIZATION OF FZD4
setSize	15
pANOVA	0.000709
s.dist	0.505
p.adjustANOVA	0.0344

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkca	8091
Prkcg	7934
Ap2a1	7394
Ap2b1	7080
Prkcb	6741
Dvl2	6555
Ap2a2	6358
Ap2m1	5729
Arrb2	4011
Clta	2910
Ap2s1	2536
Cltb	1571
Cltc	1187
Wnt5a	-1070
Fzd4	-2968

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkca	8091
Prkcg	7934
Ap2a1	7394
Ap2b1	7080
Prkcb	6741
Dvl2	6555
Ap2a2	6358
Ap2m1	5729
Arrb2	4011
Clta	2910
Ap2s1	2536
Cltb	1571
Cltc	1187
Wnt5a	-1070
Fzd4	-2968

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
	80
set	ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES
setSize	10
pANOVA	0.00592
s.dist	-0.503
p.adjustANOVA	0.123

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspa5	-8508
Xbp1	-8476
Hsp90b1	-8419
Nfya	-8351
Calr	-8276
Ddit3	-7358
Atf4	-3829
Nfyc	-47
Nfyb	4588
Atf6	5760

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspa5	-8508
Xbp1	-8476
Hsp90b1	-8419
Nfya	-8351
Calr	-8276
Ddit3	-7358
Atf4	-3829
Nfyc	-47
Nfyb	4588
Atf6	5760

CAMK IV MEDIATED PHOSPHORYLATION OF CREB

CAMK IV MEDIATED PHOSPHORYLATION OF CREB
	109
set	CAMK IV MEDIATED PHOSPHORYLATION OF CREB
setSize	10
pANOVA	0.00673
s.dist	0.495
p.adjustANOVA	0.124

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Camkk2	8297
Camkk1	8221
Camk2b	8027
Kpna2	7487
Camk2a	7008
Camk4	4797
Camk2d	4345
Camk2g	2899
Calm1	-2523
Creb1	-6695

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Camkk2	8297
Camkk1	8221
Camk2b	8027
Kpna2	7487
Camk2a	7008
Camk4	4797
Camk2d	4345
Camk2g	2899
Calm1	-2523
Creb1	-6695

CGMP EFFECTS

CGMP EFFECTS
	141
set	CGMP EFFECTS
setSize	15
pANOVA	0.00094
s.dist	0.493
p.adjustANOVA	0.0365

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pde1a	8218
Pde11a	7583
Kcnmb2	7467
Pde2a	7424
Pde9a	7242
Kcnmb4	6993
Kcnma1	6073
Itpr1	5676
Irag1	5277
Pde1b	5215
Kcnmb1	4711
Pde10a	861
Pde5a	-388
Prkg1	-2456
Prkg2	-7323

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pde1a	8218
Pde11a	7583
Kcnmb2	7467
Pde2a	7424
Pde9a	7242
Kcnmb4	6993
Kcnma1	6073
Itpr1	5676
Irag1	5277
Pde1b	5215
Kcnmb1	4711
Pde10a	861
Pde5a	-388
Prkg1	-2456
Prkg2	-7323

DNA METHYLATION

DNA METHYLATION
	251
set	DNA METHYLATION
setSize	20
pANOVA	0.000442
s.dist	-0.454
p.adjustANOVA	0.0245

Top enriched genes

Top 20 genes
GeneID	Gene Rank
H2ac18	-8348
H4c12	-7747
Uhrf1	-7604
H4c8	-7477
H2bc21	-7459
H2bc6	-6848
H2az2	-6816
H2bc4	-6707
H2bc8	-6624
H4c9	-6415
Dnmt3a	-4563
H3c15	-4019
H2aj	-2603
H3f3a	-2297
H2az1	-864
H2ac19	-532
H3f3b	-414
H4c14	138
H2ax	4083
Dnmt1	5612

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
H2ac18	-8348
H4c12	-7747
Uhrf1	-7604
H4c8	-7477
H2bc21	-7459
H2bc6	-6848
H2az2	-6816
H2bc4	-6707
H2bc8	-6624
H4c9	-6415
Dnmt3a	-4563
H3c15	-4019
H2aj	-2603
H3f3a	-2297
H2az1	-864
H2ac19	-532
H3f3b	-414
H4c14	138
H2ax	4083
Dnmt1	5612

LGI ADAM INTERACTIONS

LGI ADAM INTERACTIONS
	511
set	LGI ADAM INTERACTIONS
setSize	14
pANOVA	0.00348
s.dist	0.451
p.adjustANOVA	0.081

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Stx1a	7938
Cacng3	7889
Adam11	7834
Cacng8	7549
Dlg4	6940
Stx1b	5641
Lgi3	5514
Adam22	3626
Adam23	2458
Lgi1	1211
Lgi4	814
Lgi2	-245
Cacng4	-372
Cacng2	-3424

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Stx1a	7938
Cacng3	7889
Adam11	7834
Cacng8	7549
Dlg4	6940
Stx1b	5641
Lgi3	5514
Adam22	3626
Adam23	2458
Lgi1	1211
Lgi4	814
Lgi2	-245
Cacng4	-372
Cacng2	-3424

TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX

TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
	1117
set	TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX
setSize	12
pANOVA	0.00692
s.dist	0.45
p.adjustANOVA	0.124

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Chmp6	7060
Chmp3	6443
Pik3r4	6435
Becn1	5034
Pik3c3	4940
Chmp4b	4061
Chmp7	3408
Chmp2b	3035
Map1lc3b	2678
Chmp2a	2450
Chmp4c	1140
Uvrag	-1008

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Chmp6	7060
Chmp3	6443
Pik3r4	6435
Becn1	5034
Pik3c3	4940
Chmp4b	4061
Chmp7	3408
Chmp2b	3035
Map1lc3b	2678
Chmp2a	2450
Chmp4c	1140
Uvrag	-1008

SEROTONIN NEUROTRANSMITTER RELEASE CYCLE

SEROTONIN NEUROTRANSMITTER RELEASE CYCLE
	913
set	SEROTONIN NEUROTRANSMITTER RELEASE CYCLE
setSize	18
pANOVA	0.00102
s.dist	0.447
p.adjustANOVA	0.0379

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Stx1a	7938
Unc13b	7488
Syn1	7354
Stxbp1	7232
Ppfia3	7037
Syt1	6858
Rims1	5934
Syn2	5671
Syn3	4255
Rab3a	4251
Vamp2	4007
Ppfia4	3212
Tspoap1	2801
Snap25	2764
Ppfia2	1867
Cplx1	512
Ppfia1	-2775
Slc18a2	-8364

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Stx1a	7938
Unc13b	7488
Syn1	7354
Stxbp1	7232
Ppfia3	7037
Syt1	6858
Rims1	5934
Syn2	5671
Syn3	4255
Rab3a	4251
Vamp2	4007
Ppfia4	3212
Tspoap1	2801
Snap25	2764
Ppfia2	1867
Cplx1	512
Ppfia1	-2775
Slc18a2	-8364

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR

TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
	1093
set	TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR
setSize	11
pANOVA	0.0112
s.dist	-0.442
p.adjustANOVA	0.143

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hsp90b1	-8419
Tlr3	-7950
Ctss	-7927
Lgmn	-5222
Ctsl	-4944
Ctsk	-4723
Unc93b1	-3682
Tlr7	-3257
Tlr9	101
Ctsb	727
Cnpy3	3782

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hsp90b1	-8419
Tlr3	-7950
Ctss	-7927
Lgmn	-5222
Ctsl	-4944
Ctsk	-4723
Unc93b1	-3682
Tlr7	-3257
Tlr9	101
Ctsb	727
Cnpy3	3782

DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS

DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS
	234
set	DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS
setSize	18
pANOVA	0.00126
s.dist	0.439
p.adjustANOVA	0.0408

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Srd5a3	7833
Glb1	7481
Mpi	7156
Dolk	6220
Dpm3	6197
Dhdds	6188
Gne	6149
Galt	5683
Gale	4936
Dpm1	4736
Ctsa	3765
Dpm2	3381
Neu1	2229
Pmm2	2162
Galk1	1265
Pgm1	-1727
Gfpt1	-2249
Nus1	-4630

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Srd5a3	7833
Glb1	7481
Mpi	7156
Dolk	6220
Dpm3	6197
Dhdds	6188
Gne	6149
Galt	5683
Gale	4936
Dpm1	4736
Ctsa	3765
Dpm2	3381
Neu1	2229
Pmm2	2162
Galk1	1265
Pgm1	-1727
Gfpt1	-2249
Nus1	-4630

NUCLEOTIDE LIKE PURINERGIC RECEPTORS

NUCLEOTIDE LIKE PURINERGIC RECEPTORS
	653
set	NUCLEOTIDE LIKE PURINERGIC RECEPTORS
setSize	12
pANOVA	0.00852
s.dist	-0.439
p.adjustANOVA	0.13

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Adora3	-8301
P2ry13	-8282
Adora2b	-7728
Gpr17	-7614
P2ry12	-7476
P2ry14	-5282
Lpar4	-5063
P2ry6	-3039
Lpar6	-1656
P2ry1	464
Adora2a	591
Adora1	8419

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Adora3	-8301
P2ry13	-8282
Adora2b	-7728
Gpr17	-7614
P2ry12	-7476
P2ry14	-5282
Lpar4	-5063
P2ry6	-3039
Lpar6	-1656
P2ry1	464
Adora2a	591
Adora1	8419

MUCOPOLYSACCHARIDOSES

MUCOPOLYSACCHARIDOSES
	583
set	MUCOPOLYSACCHARIDOSES
setSize	11
pANOVA	0.012
s.dist	0.437
p.adjustANOVA	0.148

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Naglu	8479
Glb1	7481
Galns	5932
Hgsnat	5889
Sgsh	5045
Arsb	4866
Hyal1	4403
Gns	1421
Gusb	460
Ids	-1372
Idua	-1926

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Naglu	8479
Glb1	7481
Galns	5932
Hgsnat	5889
Sgsh	5045
Arsb	4866
Hyal1	4403
Gns	1421
Gusb	460
Ids	-1372
Idua	-1926

TRAFFICKING OF AMPA RECEPTORS

TRAFFICKING OF AMPA RECEPTORS
	1094
set	TRAFFICKING OF AMPA RECEPTORS
setSize	31
pANOVA	2.84e-05
s.dist	0.434
p.adjustANOVA	0.00456

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Prkca	8091
Camk2b	8027
Prkcg	7934
Cacng3	7889
Cacng8	7549
Ap2a1	7394
Nsf	7135
Ap2b1	7080
Camk2a	7008
Dlg4	6940
Prkcb	6741
Ap2a2	6358
Gria3	6301
Akap5	6204
Pick1	5747
Ap2m1	5729
Gria1	5278
Grip1	4534
Camk2d	4345
Gria2	3969

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Prkca	8091
Camk2b	8027
Prkcg	7934
Cacng3	7889
Cacng8	7549
Ap2a1	7394
Nsf	7135
Ap2b1	7080
Camk2a	7008
Dlg4	6940
Prkcb	6741
Ap2a2	6358
Gria3	6301
Akap5	6204
Pick1	5747
Ap2m1	5729
Gria1	5278
Grip1	4534
Camk2d	4345
Gria2	3969
Camk2g	2899
Ap2s1	2536
Epb41l1	1917
Tspan7	1433
Gria4	120
Dlg1	61
Cacng4	-372
Cacng2	-3424
Grip2	-6880
Myo6	-7334
Mdm2	-7509

SHC MEDIATED CASCADE FGFR4

SHC MEDIATED CASCADE FGFR4
	917
set	SHC MEDIATED CASCADE FGFR4
setSize	11
pANOVA	0.0152
s.dist	-0.423
p.adjustANOVA	0.175

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fgf9	-8111
Nras	-8042
Fgf2	-8002
Fgf18	-7611
Fgf1	-7475
Kras	-4796
Sos1	-4081
Shc1	-3374
Hras	-19
Grb2	4493
Fgf16	7270

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fgf9	-8111
Nras	-8042
Fgf2	-8002
Fgf18	-7611
Fgf1	-7475
Kras	-4796
Sos1	-4081
Shc1	-3374
Hras	-19
Grb2	4493
Fgf16	7270

SIGNALING BY HIPPO

SIGNALING BY HIPPO
	953
set	SIGNALING BY HIPPO
setSize	20
pANOVA	0.00124
s.dist	-0.417
p.adjustANOVA	0.0408

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tjp2	-8083
Amotl2	-7597
Sav1	-7390
Amotl1	-7259
Tjp1	-7253
Stk3	-6856
Mob1a	-6776
Casp3	-6671
Wwtr1	-5903
Stk4	-5711
Lats1	-5682
Mob1b	-5515
Lats2	-4702
Amot	-4025
Ywhae	-970
Yap1	1104
Wwc1	1524
Ywhab	1545
Dvl2	6555
Nphp4	8375

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tjp2	-8083
Amotl2	-7597
Sav1	-7390
Amotl1	-7259
Tjp1	-7253
Stk3	-6856
Mob1a	-6776
Casp3	-6671
Wwtr1	-5903
Stk4	-5711
Lats1	-5682
Mob1b	-5515
Lats2	-4702
Amot	-4025
Ywhae	-970
Yap1	1104
Wwc1	1524
Ywhab	1545
Dvl2	6555
Nphp4	8375

INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION

INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION
	483
set	INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION
setSize	13
pANOVA	0.0101
s.dist	-0.412
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Serpine2	-7671
Pros1	-6994
Vwf	-6657
Serpind1	-6322
F8	-6292
Prcp	-5390
Serping1	-4239
Serpinc1	-3407
Gp5	-3223
Gp1bb	-1929
C1qbp	-1897
A2m	-141
Gp1ba	8379

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Serpine2	-7671
Pros1	-6994
Vwf	-6657
Serpind1	-6322
F8	-6292
Prcp	-5390
Serping1	-4239
Serpinc1	-3407
Gp5	-3223
Gp1bb	-1929
C1qbp	-1897
A2m	-141
Gp1ba	8379

HSF1 ACTIVATION

HSF1 ACTIVATION
	426
set	HSF1 ACTIVATION
setSize	27
pANOVA	0.00024
s.dist	-0.408
p.adjustANOVA	0.0174

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Serpinh1	-8522
Hspb1	-8520
Fkbp4	-8515
Hsph1	-8479
Hspa1b	-8409
Hspa1a	-8371
Dnajb1	-8303
Hsp90aa1	-7811
Dedd2	-7321
Rpa1	-6820
Ptges3	-6554
Col4a6	-5419
Hsp90ab1	-4459
Rln1	-3680
Rpa2	-2399
Mrpl18	-2116
Cryba4	-1416
Dnajb6	-1244
Ywhae	-970
Eef1a1	-401

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Serpinh1	-8522
Hspb1	-8520
Fkbp4	-8515
Hsph1	-8479
Hspa1b	-8409
Hspa1a	-8371
Dnajb1	-8303
Hsp90aa1	-7811
Dedd2	-7321
Rpa1	-6820
Ptges3	-6554
Col4a6	-5419
Hsp90ab1	-4459
Rln1	-3680
Rpa2	-2399
Mrpl18	-2116
Cryba4	-1416
Dnajb6	-1244
Ywhae	-970
Eef1a1	-401
Rpa3	478
Hdac6	558
Vcp	799
Ubb	1348
Hsf1	2256
Hsbp1	3840
Tnfrsf21	6286

UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION

UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION
	1144
set	UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION
setSize	21
pANOVA	0.00131
s.dist	0.405
p.adjustANOVA	0.0413

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Camk2b	8027
Grin1	7629
Dlg3	7480
Grin2c	7110
Camk2a	7008
Dlg4	6940
Gria3	6301
Grin2b	6241
Actn2	5570
Gria1	5278
Grin2a	4615
Camk2d	4345
Gria2	3969
Camk2g	2899
Lrrc7	2260
Gria4	120
Dlg1	61
Grin2d	-2102
Calm1	-2523
Dlg2	-3794

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Camk2b	8027
Grin1	7629
Dlg3	7480
Grin2c	7110
Camk2a	7008
Dlg4	6940
Gria3	6301
Grin2b	6241
Actn2	5570
Gria1	5278
Grin2a	4615
Camk2d	4345
Gria2	3969
Camk2g	2899
Lrrc7	2260
Gria4	120
Dlg1	61
Grin2d	-2102
Calm1	-2523
Dlg2	-3794
Nefl	-5602

SIGNALING BY FGFR3 FUSIONS IN CANCER

SIGNALING BY FGFR3 FUSIONS IN CANCER
	946
set	SIGNALING BY FGFR3 FUSIONS IN CANCER
setSize	10
pANOVA	0.0269
s.dist	-0.404
p.adjustANOVA	0.232

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gab1	-8223
Nras	-8042
Pik3ca	-7797
Kras	-4796
Frs2	-4087
Sos1	-4081
Fgfr3	-4029
Hras	-19
Pik3r1	2027
Grb2	4493

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gab1	-8223
Nras	-8042
Pik3ca	-7797
Kras	-4796
Frs2	-4087
Sos1	-4081
Fgfr3	-4029
Hras	-19
Pik3r1	2027
Grb2	4493

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING

PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
	729
set	PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING
setSize	11
pANOVA	0.0213
s.dist	0.401
p.adjustANOVA	0.208

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Cacna1b	7716
Cacna1e	7333
Cacnb3	6883
Cacnb1	6597
Cacna1a	5931
Cacna2d3	4358
Cacnb2	1475
Cacna2d2	1251
Cacng4	-372
Cacnb4	-469
Cacng2	-3424

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Cacna1b	7716
Cacna1e	7333
Cacnb3	6883
Cacnb1	6597
Cacna1a	5931
Cacna2d3	4358
Cacnb2	1475
Cacna2d2	1251
Cacng4	-372
Cacnb4	-469
Cacng2	-3424

NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10

NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10
	618
set	NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10
setSize	11
pANOVA	0.0218
s.dist	-0.399
p.adjustANOVA	0.21

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ifih1	-8330
Ripk1	-7581
Casp8	-7196
Chuk	-6067
Rnf135	-4521
Trim25	-2446
Ddx58	-2254
Mavs	-1764
Ikbkg	-1408
Ikbkb	397
Fadd	3615

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ifih1	-8330
Ripk1	-7581
Casp8	-7196
Chuk	-6067
Rnf135	-4521
Trim25	-2446
Ddx58	-2254
Mavs	-1764
Ikbkg	-1408
Ikbkb	397
Fadd	3615

CONDENSATION OF PROPHASE CHROMOSOMES

CONDENSATION OF PROPHASE CHROMOSOMES
	170
set	CONDENSATION OF PROPHASE CHROMOSOMES
setSize	28
pANOVA	0.000297
s.dist	-0.395
p.adjustANOVA	0.0182

Top enriched genes

Top 20 genes
GeneID	Gene Rank
H2ac18	-8348
H4c12	-7747
H4c8	-7477
H2bc21	-7459
H2bc6	-6848
H2az2	-6816
Kmt5a	-6768
H2bc4	-6707
H2bc8	-6624
H4c9	-6415
Smc2	-6023
Smc4	-5878
Ncapg2	-5514
Set	-4883
H3c15	-4019
Rb1	-3454
H2aj	-2603
H3f3a	-2297
H2az1	-864
H2ac19	-532

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
H2ac18	-8348
H4c12	-7747
H4c8	-7477
H2bc21	-7459
H2bc6	-6848
H2az2	-6816
Kmt5a	-6768
H2bc4	-6707
H2bc8	-6624
H4c9	-6415
Smc2	-6023
Smc4	-5878
Ncapg2	-5514
Set	-4883
H3c15	-4019
Rb1	-3454
H2aj	-2603
H3f3a	-2297
H2az1	-864
H2ac19	-532
Mcph1	-454
H3f3b	-414
Ncapd3	-249
H4c14	138
Plk1	1976
Phf8	2818
H2ax	4083
Ncaph2	4911

CROSSLINKING OF COLLAGEN FIBRILS

CROSSLINKING OF COLLAGEN FIBRILS
	189
set	CROSSLINKING OF COLLAGEN FIBRILS
setSize	14
pANOVA	0.0112
s.dist	0.391
p.adjustANOVA	0.143

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pcolce	7956
Col4a2	7647
Pxdn	6822
Bmp1	6796
Col1a1	6512
Tll1	6180
Col4a1	5625
Loxl1	4862
Loxl2	4292
Col4a5	1455
Loxl3	-1273
Tll2	-2579
Col1a2	-2588
Col4a6	-5419

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pcolce	7956
Col4a2	7647
Pxdn	6822
Bmp1	6796
Col1a1	6512
Tll1	6180
Col4a1	5625
Loxl1	4862
Loxl2	4292
Col4a5	1455
Loxl3	-1273
Tll2	-2579
Col1a2	-2588
Col4a6	-5419

NEUROTOXICITY OF CLOSTRIDIUM TOXINS

NEUROTOXICITY OF CLOSTRIDIUM TOXINS
	614
set	NEUROTOXICITY OF CLOSTRIDIUM TOXINS
setSize	10
pANOVA	0.0324
s.dist	0.391
p.adjustANOVA	0.248

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Sv2b	8281
Stx1a	7938
Syt1	6858
Stx1b	5641
Sv2a	4695
Vamp2	4007
Snap25	2764
Sv2c	1325
Syt2	-4028
Vamp1	-4481

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Sv2b	8281
Stx1a	7938
Syt1	6858
Stx1b	5641
Sv2a	4695
Vamp2	4007
Snap25	2764
Sv2c	1325
Syt2	-4028
Vamp1	-4481

CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND

CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND
	116
set	CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND
setSize	13
pANOVA	0.0152
s.dist	-0.389
p.adjustANOVA	0.175

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Tnfsf10	-8485
Cd14	-8329
Ripk1	-7581
Tlr4	-7369
Casp8	-7196
Tnfrsf10b	-5896
Ticam2	-5065
Cflar	-2954
Traf2	-2620
Tradd	990
Fas	3329
Fadd	3615
Ticam1	4321

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Tnfsf10	-8485
Cd14	-8329
Ripk1	-7581
Tlr4	-7369
Casp8	-7196
Tnfrsf10b	-5896
Ticam2	-5065
Cflar	-2954
Traf2	-2620
Tradd	990
Fas	3329
Fadd	3615
Ticam1	4321

ATF6 ATF6 ALPHA ACTIVATES CHAPERONES

ATF6 ATF6 ALPHA ACTIVATES CHAPERONES
	81
set	ATF6 ATF6 ALPHA ACTIVATES CHAPERONES
setSize	12
pANOVA	0.0199
s.dist	-0.388
p.adjustANOVA	0.202

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Hspa5	-8508
Xbp1	-8476
Hsp90b1	-8419
Nfya	-8351
Calr	-8276
Ddit3	-7358
Atf4	-3829
Mbtps2	-3818
Nfyc	-47
Nfyb	4588
Atf6	5760
Mbtps1	6915

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Hspa5	-8508
Xbp1	-8476
Hsp90b1	-8419
Nfya	-8351
Calr	-8276
Ddit3	-7358
Atf4	-3829
Mbtps2	-3818
Nfyc	-47
Nfyb	4588
Atf6	5760
Mbtps1	6915

RETROGRADE NEUROTROPHIN SIGNALLING

RETROGRADE NEUROTROPHIN SIGNALLING
	834
set	RETROGRADE NEUROTROPHIN SIGNALLING
setSize	14
pANOVA	0.0121
s.dist	0.387
p.adjustANOVA	0.148

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Dnm1	7420
Ap2a1	7394
Ap2b1	7080
Ap2a2	6358
Sh3gl2	6061
Ap2m1	5729
Dnal4	3744
Clta	2910
Ap2s1	2536
Ngf	2217
Cltc	1187
Dnm2	-552
Ntrk1	-1523
Dnm3	-4756

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Dnm1	7420
Ap2a1	7394
Ap2b1	7080
Ap2a2	6358
Sh3gl2	6061
Ap2m1	5729
Dnal4	3744
Clta	2910
Ap2s1	2536
Ngf	2217
Cltc	1187
Dnm2	-552
Ntrk1	-1523
Dnm3	-4756

TRAF6 MEDIATED IRF7 ACTIVATION

TRAF6 MEDIATED IRF7 ACTIVATION
	1090
set	TRAF6 MEDIATED IRF7 ACTIVATION
setSize	15
pANOVA	0.0102
s.dist	-0.383
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ifih1	-8330
Irf7	-8101
Traf6	-7783
Tank	-5965
Tbk1	-5931
Rnf135	-4521
Sike1	-3450
Traf2	-2620
Trim25	-2446
Ep300	-2267
Ddx58	-2254
Mavs	-1764
Irf3	-1173
Crebbp	2884
Ikbke	4612

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ifih1	-8330
Irf7	-8101
Traf6	-7783
Tank	-5965
Tbk1	-5931
Rnf135	-4521
Sike1	-3450
Traf2	-2620
Trim25	-2446
Ep300	-2267
Ddx58	-2254
Mavs	-1764
Irf3	-1173
Crebbp	2884
Ikbke	4612

ATTENUATION PHASE

ATTENUATION PHASE
	82
set	ATTENUATION PHASE
setSize	25
pANOVA	0.000934
s.dist	-0.382
p.adjustANOVA	0.0365

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Serpinh1	-8522
Hspb1	-8520
Fkbp4	-8515
Hsph1	-8479
Hspa1b	-8409
Hspa1a	-8371
Dnajb1	-8303
Hsp90aa1	-7811
Hspa8	-7724
Dedd2	-7321
Ptges3	-6554
Col4a6	-5419
Hsp90ab1	-4459
Rln1	-3680
Ep300	-2267
Mrpl18	-2116
Cryba4	-1416
Dnajb6	-1244
Ubb	1348
Hsf1	2256

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Serpinh1	-8522
Hspb1	-8520
Fkbp4	-8515
Hsph1	-8479
Hspa1b	-8409
Hspa1a	-8371
Dnajb1	-8303
Hsp90aa1	-7811
Hspa8	-7724
Dedd2	-7321
Ptges3	-6554
Col4a6	-5419
Hsp90ab1	-4459
Rln1	-3680
Ep300	-2267
Mrpl18	-2116
Cryba4	-1416
Dnajb6	-1244
Ubb	1348
Hsf1	2256
Crebbp	2884
Hspa1l	3116
Hsbp1	3840
Tnfrsf21	6286
Hspa2	7713

PI 3K CASCADE FGFR4

PI 3K CASCADE FGFR4
	696
set	PI 3K CASCADE FGFR4
setSize	11
pANOVA	0.0304
s.dist	-0.377
p.adjustANOVA	0.242

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Gab1	-8223
Fgf9	-8111
Fgf2	-8002
Pik3ca	-7797
Fgf18	-7611
Fgf1	-7475
Frs2	-4087
Pik3r1	2027
Ptpn11	2062
Grb2	4493
Fgf16	7270

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Gab1	-8223
Fgf9	-8111
Fgf2	-8002
Pik3ca	-7797
Fgf18	-7611
Fgf1	-7475
Frs2	-4087
Pik3r1	2027
Ptpn11	2062
Grb2	4493
Fgf16	7270

DOPAMINE NEUROTRANSMITTER RELEASE CYCLE

DOPAMINE NEUROTRANSMITTER RELEASE CYCLE
	256
set	DOPAMINE NEUROTRANSMITTER RELEASE CYCLE
setSize	23
pANOVA	0.00182
s.dist	0.376
p.adjustANOVA	0.0505

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Stx1a	7938
Unc13b	7488
Syn1	7354
Stxbp1	7232
Ppfia3	7037
Syt1	6858
Rims1	5934
Syn2	5671
Syn3	4255
Rab3a	4251
Vamp2	4007
Lin7b	3533
Ppfia4	3212
Tspoap1	2801
Snap25	2764
Ppfia2	1867
Cask	1508
Lin7a	1004
Cplx1	512
Apba1	127

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Stx1a	7938
Unc13b	7488
Syn1	7354
Stxbp1	7232
Ppfia3	7037
Syt1	6858
Rims1	5934
Syn2	5671
Syn3	4255
Rab3a	4251
Vamp2	4007
Lin7b	3533
Ppfia4	3212
Tspoap1	2801
Snap25	2764
Ppfia2	1867
Cask	1508
Lin7a	1004
Cplx1	512
Apba1	127
Lin7c	-1316
Ppfia1	-2775
Slc18a2	-8364

DEFECTS IN COBALAMIN B12 METABOLISM

DEFECTS IN COBALAMIN B12 METABOLISM
	217
set	DEFECTS IN COBALAMIN B12 METABOLISM
setSize	12
pANOVA	0.0277
s.dist	-0.367
p.adjustANOVA	0.235

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Mmut	-7915
Mtrr	-7591
Abcd4	-6939
Mmaa	-6321
Mmadhc	-5236
Mmachc	-4429
Lmbrd1	-4231
Tcn2	-3809
Cd320	-2432
Mtr	-2248
Amn	5929
Mmab	7539

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Mmut	-7915
Mtrr	-7591
Abcd4	-6939
Mmaa	-6321
Mmadhc	-5236
Mmachc	-4429
Lmbrd1	-4231
Tcn2	-3809
Cd320	-2432
Mtr	-2248
Amn	5929
Mmab	7539

SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION

SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION
	990
set	SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION
setSize	25
pANOVA	0.00182
s.dist	-0.36
p.adjustANOVA	0.0505

Top enriched genes

Top 20 genes
GeneID	Gene Rank
H2ac18	-8348
H4c12	-7747
H4c8	-7477
H2bc21	-7459
H2bc6	-6848
H2az2	-6816
H2bc4	-6707
H2bc8	-6624
H4c9	-6415
Taf1a	-6340
Sirt1	-4712
H3c15	-4019
Suv39h1	-3076
Taf1d	-2841
H2aj	-2603
H3f3a	-2297
H2az1	-864
H2ac19	-532
H3f3b	-414
Taf1c	-36

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
H2ac18	-8348
H4c12	-7747
H4c8	-7477
H2bc21	-7459
H2bc6	-6848
H2az2	-6816
H2bc4	-6707
H2bc8	-6624
H4c9	-6415
Taf1a	-6340
Sirt1	-4712
H3c15	-4019
Suv39h1	-3076
Taf1d	-2841
H2aj	-2603
H3f3a	-2297
H2az1	-864
H2ac19	-532
H3f3b	-414
Taf1c	-36
H4c14	138
Rrp8	585
Taf1b	3775
H2ax	4083
Tbp	6609

ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE

ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE
	8
set	ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE
setSize	17
pANOVA	0.0102
s.dist	0.36
p.adjustANOVA	0.137

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Stx1a	7938
Unc13b	7488
Stxbp1	7232
Ppfia3	7037
Syt1	6858
Rims1	5934
Rab3a	4251
Vamp2	4007
Ppfia4	3212
Tspoap1	2801
Snap25	2764
Ppfia2	1867
Cplx1	512
Chat	444
Slc18a3	-2007
Ppfia1	-2775
Slc5a7	-5917

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Stx1a	7938
Unc13b	7488
Stxbp1	7232
Ppfia3	7037
Syt1	6858
Rims1	5934
Rab3a	4251
Vamp2	4007
Ppfia4	3212
Tspoap1	2801
Snap25	2764
Ppfia2	1867
Cplx1	512
Chat	444
Slc18a3	-2007
Ppfia1	-2775
Slc5a7	-5917

CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2

CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2
	175
set	CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2
setSize	11
pANOVA	0.0388
s.dist	-0.36
p.adjustANOVA	0.275

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ptpn12	-8331
Nras	-8042
Hsp90aa1	-7811
Erbin	-7214
Kras	-4796
Sos1	-4081
Shc1	-3374
Hras	-19
Erbb2	1862
Cdc37	3453
Grb2	4493

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ptpn12	-8331
Nras	-8042
Hsp90aa1	-7811
Erbin	-7214
Kras	-4796
Sos1	-4081
Shc1	-3374
Hras	-19
Erbb2	1862
Cdc37	3453
Grb2	4493

RRNA PROCESSING IN THE MITOCHONDRION

RRNA PROCESSING IN THE MITOCHONDRION
	887
set	RRNA PROCESSING IN THE MITOCHONDRION
setSize	10
pANOVA	0.0494
s.dist	0.359
p.adjustANOVA	0.306

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Elac2	8075
Prorp	6607
Tfb1m	5112
Mterf4	4202
Nsun4	3758
Trmt10c	3705
Mrm1	3236
Mrm2	678
Hsd17b10	-1176
Mrm3	-3897

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Elac2	8075
Prorp	6607
Tfb1m	5112
Mterf4	4202
Nsun4	3758
Trmt10c	3705
Mrm1	3236
Mrm2	678
Hsd17b10	-1176
Mrm3	-3897

INTERLEUKIN 10 SIGNALING

INTERLEUKIN 10 SIGNALING
	464
set	INTERLEUKIN 10 SIGNALING
setSize	19
pANOVA	0.00748
s.dist	-0.354
p.adjustANOVA	0.126

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Icam1	-8494
Ccr5	-8441
Cd86	-8220
Il10rb	-8095
Il1a	-7481
Tnfrsf1b	-7043
Lif	-6639
Csf1	-5356
Il10ra	-4188
Ptafr	-3803
Il18	-3795
Cd80	-1872
Tnfrsf1a	-1298
Il1r1	-1016
Stat3	-801
Tyk2	1654
Jak1	3233
Ptgs2	6479
Fcer2a	7586

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Icam1	-8494
Ccr5	-8441
Cd86	-8220
Il10rb	-8095
Il1a	-7481
Tnfrsf1b	-7043
Lif	-6639
Csf1	-5356
Il10ra	-4188
Ptafr	-3803
Il18	-3795
Cd80	-1872
Tnfrsf1a	-1298
Il1r1	-1016
Stat3	-801
Tyk2	1654
Jak1	3233
Ptgs2	6479
Fcer2a	7586

INTERACTION BETWEEN L1 AND ANKYRINS

INTERACTION BETWEEN L1 AND ANKYRINS
	455
set	INTERACTION BETWEEN L1 AND ANKYRINS
setSize	29
pANOVA	0.00104
s.dist	0.352
p.adjustANOVA	0.0379

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Scn10a	8402
Sptbn5	8340
Sptbn2	7435
Scn8a	7173
Actb	6914
Scn1b	6803
Nrcam	6783
L1cam	6521
Sptan1	6269
Kcnq2	5969
Scn2a	5523
Scn3b	5281
Sptb	4723
Actg1	4415
Sptbn4	4260
Scn2b	2738
Scn4b	2575
Sptbn1	2521
Nfasc	2313
Ank2	2029

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Scn10a	8402
Sptbn5	8340
Sptbn2	7435
Scn8a	7173
Actb	6914
Scn1b	6803
Nrcam	6783
L1cam	6521
Sptan1	6269
Kcnq2	5969
Scn2a	5523
Scn3b	5281
Sptb	4723
Actg1	4415
Sptbn4	4260
Scn2b	2738
Scn4b	2575
Sptbn1	2521
Nfasc	2313
Ank2	2029
Kcnq3	1196
Ank3	-102
Ank1	-1579
Scn3a	-1671
Scn5a	-1798
Scn7a	-2293
Scn1a	-2963
Scn11a	-5321
Scn9a	-6412

GLYCOGEN BREAKDOWN GLYCOGENOLYSIS

GLYCOGEN BREAKDOWN GLYCOGENOLYSIS
	383
set	GLYCOGEN BREAKDOWN GLYCOGENOLYSIS
setSize	14
pANOVA	0.0227
s.dist	-0.352
p.adjustANOVA	0.214

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Phka1	-7315
Gyg	-6772
Pygb	-5821
Pgm2	-5358
Phkg2	-4838
Phkb	-4393
Pygm	-4296
Agl	-4222
Pygl	-3764
Phkg1	-3017
Calm1	-2523
Gaa	1653
Pgm2l1	1810
Phka2	6738

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Phka1	-7315
Gyg	-6772
Pygb	-5821
Pgm2	-5358
Phkg2	-4838
Phkb	-4393
Pygm	-4296
Agl	-4222
Pygl	-3764
Phkg1	-3017
Calm1	-2523
Gaa	1653
Pgm2l1	1810
Phka2	6738

FORMATION OF THE CORNIFIED ENVELOPE

FORMATION OF THE CORNIFIED ENVELOPE
	333
set	FORMATION OF THE CORNIFIED ENVELOPE
setSize	26
pANOVA	0.00204
s.dist	0.349
p.adjustANOVA	0.0528

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Krt9	8412
St14	8252
Pkp2	8139
Evpl	8122
Capn1	7941
Tchh	7887
Krt20	7338
Krt77	7044
Ppl	6106
Perp	5493
Krt73	4161
Klk8	3646
Dsc3	3280
Krt10	2444
Capns1	2360
Lor	2297
Furin	1847
Jup	1021
Krt18	888
Dsp	735

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Krt9	8412
St14	8252
Pkp2	8139
Evpl	8122
Capn1	7941
Tchh	7887
Krt20	7338
Krt77	7044
Ppl	6106
Perp	5493
Krt73	4161
Klk8	3646
Dsc3	3280
Krt10	2444
Capns1	2360
Lor	2297
Furin	1847
Jup	1021
Krt18	888
Dsp	735
Krt12	-969
Kazn	-1202
Dsg2	-1722
Pcsk6	-4950
Pkp4	-5313
Krt1	-6628

KERATINIZATION

KERATINIZATION
	501
set	KERATINIZATION
setSize	26
pANOVA	0.00204
s.dist	0.349
p.adjustANOVA	0.0528

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Krt9	8412
St14	8252
Pkp2	8139
Evpl	8122
Capn1	7941
Tchh	7887
Krt20	7338
Krt77	7044
Ppl	6106
Perp	5493
Krt73	4161
Klk8	3646
Dsc3	3280
Krt10	2444
Capns1	2360
Lor	2297
Furin	1847
Jup	1021
Krt18	888
Dsp	735

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Krt9	8412
St14	8252
Pkp2	8139
Evpl	8122
Capn1	7941
Tchh	7887
Krt20	7338
Krt77	7044
Ppl	6106
Perp	5493
Krt73	4161
Klk8	3646
Dsc3	3280
Krt10	2444
Capns1	2360
Lor	2297
Furin	1847
Jup	1021
Krt18	888
Dsp	735
Krt12	-969
Kazn	-1202
Dsg2	-1722
Pcsk6	-4950
Pkp4	-5313
Krt1	-6628

FRS MEDIATED FGFR4 SIGNALING

FRS MEDIATED FGFR4 SIGNALING
	343
set	FRS MEDIATED FGFR4 SIGNALING
setSize	13
pANOVA	0.0297
s.dist	-0.348
p.adjustANOVA	0.242

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Fgf9	-8111
Nras	-8042
Fgf2	-8002
Fgf18	-7611
Fgf1	-7475
Kras	-4796
Frs2	-4087
Sos1	-4081
Frs3	-338
Hras	-19
Ptpn11	2062
Grb2	4493
Fgf16	7270

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Fgf9	-8111
Nras	-8042
Fgf2	-8002
Fgf18	-7611
Fgf1	-7475
Kras	-4796
Frs2	-4087
Sos1	-4081
Frs3	-338
Hras	-19
Ptpn11	2062
Grb2	4493
Fgf16	7270

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE

SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
	1035
set	SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE
setSize	15
pANOVA	0.0196
s.dist	0.348
p.adjustANOVA	0.202

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Arf3	8239
Fig4	7690
Pi4ka	7462
Arf1	6982
Pik3r4	6435
Vac14	5967
Inpp5e	5242
Pik3c3	4940
Pi4k2a	4042
Pi4kb	633
Pi4k2b	371
Pikfyve	-700
Ocrl	-1264
Pik3c2a	-4493
Sacm1l	-7466

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Arf3	8239
Fig4	7690
Pi4ka	7462
Arf1	6982
Pik3r4	6435
Vac14	5967
Inpp5e	5242
Pik3c3	4940
Pi4k2a	4042
Pi4kb	633
Pi4k2b	371
Pikfyve	-700
Ocrl	-1264
Pik3c2a	-4493
Sacm1l	-7466

TRAF3 DEPENDENT IRF ACTIVATION PATHWAY

TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
	1088
set	TRAF3 DEPENDENT IRF ACTIVATION PATHWAY
setSize	13
pANOVA	0.0312
s.dist	-0.345
p.adjustANOVA	0.242

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Ifih1	-8330
Irf7	-8101
Tbk1	-5931
Traf3	-5653
Rnf135	-4521
Sike1	-3450
Trim25	-2446
Ep300	-2267
Ddx58	-2254
Mavs	-1764
Irf3	-1173
Crebbp	2884
Ikbke	4612

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Ifih1	-8330
Irf7	-8101
Tbk1	-5931
Traf3	-5653
Rnf135	-4521
Sike1	-3450
Trim25	-2446
Ep300	-2267
Ddx58	-2254
Mavs	-1764
Irf3	-1173
Crebbp	2884
Ikbke	4612

PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION

PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION
	753
set	PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION
setSize	23
pANOVA	0.00441
s.dist	-0.343
p.adjustANOVA	0.0968

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Nfkb2	-7543
Il1a	-7481
C3ar1	-7353
Pycard	-7241
Entpd1	-6854
Sugt1	-6360
Casp1	-5869
Rela	-5667
Nlrp3	-5663
Nfkb1	-5333
Entpd5	-5215
Txnip	-4663
Hsp90ab1	-4459
Il18	-3795
P2rx7	-1704
P2rx4	-723
C3	-711
Hmox1	-613
Pstpip1	447
Txn1	2081

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Nfkb2	-7543
Il1a	-7481
C3ar1	-7353
Pycard	-7241
Entpd1	-6854
Sugt1	-6360
Casp1	-5869
Rela	-5667
Nlrp3	-5663
Nfkb1	-5333
Entpd5	-5215
Txnip	-4663
Hsp90ab1	-4459
Il18	-3795
P2rx7	-1704
P2rx4	-723
C3	-711
Hmox1	-613
Pstpip1	447
Txn1	2081
Nt5e	3971
App	6496
Gsdmd	6789

DSCAM INTERACTIONS

DSCAM INTERACTIONS
	267
set	DSCAM INTERACTIONS
setSize	10
pANOVA	0.0607
s.dist	0.343
p.adjustANOVA	0.334

Top enriched genes

Top 20 genes
GeneID	Gene Rank
Pak1	7075
Mapk11	6893
Dscaml1	5224
Ntn1	4776
Dscam	3786
Mapk8	3304
Mapk14	100
Dcc	-470
Mapk12	-499
Rac1	-1278

Click HERE to show all gene set members

All member genes
GeneID	Gene Rank
Pak1	7075
Mapk11	6893
Dscaml1	5224
Ntn1	4776
Dscam	3786
Mapk8	3304
Mapk14	100
Dcc	-470
Mapk12	-499
Rac1	-1278

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.3                echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.4               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58.1               fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.1        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.4        
## [23] IRanges_2.30.1              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.2               stringr_1.4.1              
## [29] dplyr_1.0.10                purrr_0.3.5                
## [31] readr_2.1.3                 tidyr_1.2.1                
## [33] tibble_3.1.8                ggplot2_3.3.6              
## [35] tidyverse_1.3.2             zoo_1.8-11                 
## 
## loaded via a namespace (and not attached):
##   [1] googledrive_2.0.0      colorspace_2.0-3       ellipsis_0.3.2        
##   [4] XVector_0.36.0         fs_1.5.2               rstudioapi_0.14       
##   [7] bit64_4.0.5            AnnotationDbi_1.58.0   fansi_1.0.3           
##  [10] lubridate_1.8.0        xml2_1.3.3             codetools_0.2-18      
##  [13] splines_4.2.1          cachem_1.0.6           knitr_1.40            
##  [16] geneplotter_1.74.0     jsonlite_1.8.2         broom_1.0.1           
##  [19] annotate_1.74.0        dbplyr_2.2.1           png_0.1-7             
##  [22] shiny_1.7.2            compiler_4.2.1         httr_1.4.4            
##  [25] backports_1.4.1        assertthat_0.2.1       Matrix_1.5-1          
##  [28] fastmap_1.1.0          gargle_1.2.1           cli_3.4.1             
##  [31] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
##  [34] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
##  [37] fastmatch_1.1-3        Rcpp_1.0.9             jquerylib_0.1.4       
##  [40] cellranger_1.1.0       vctrs_0.4.2            Biostrings_2.64.1     
##  [43] svglite_2.1.0          xfun_0.33              rvest_1.0.3           
##  [46] mime_0.12              lifecycle_1.0.3        XML_3.99-0.11         
##  [49] googlesheets4_1.0.1    zlibbioc_1.42.0        scales_1.2.1          
##  [52] hms_1.1.2              promises_1.2.0.1       parallel_4.2.1        
##  [55] RColorBrewer_1.1-3     yaml_2.3.5             memoise_2.0.1         
##  [58] gridExtra_2.3          sass_0.4.2             reshape_0.8.9         
##  [61] stringi_1.7.8          RSQLite_2.2.18         highr_0.9             
##  [64] genefilter_1.78.0      caTools_1.18.2         BiocParallel_1.30.3   
##  [67] systemfonts_1.0.4      rlang_1.0.6            pkgconfig_2.0.3       
##  [70] bitops_1.0-7           evaluate_0.17          lattice_0.20-45       
##  [73] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.2.0      
##  [76] plyr_1.8.7             magrittr_2.0.3         R6_2.5.1              
##  [79] generics_0.1.3         DelayedArray_0.22.0    DBI_1.1.3             
##  [82] pillar_1.8.1           haven_2.5.1            withr_2.5.0           
##  [85] survival_3.4-0         KEGGREST_1.36.3        RCurl_1.98-1.9        
##  [88] modelr_0.1.9           crayon_1.5.2           KernSmooth_2.23-20    
##  [91] utf8_1.2.2             rmarkdown_2.17         tzdb_0.3.0            
##  [94] locfit_1.5-9.6         grid_4.2.1             readxl_1.4.1          
##  [97] data.table_1.14.2      blob_1.2.3             webshot_0.5.4         
## [100] reprex_2.0.2           digest_0.6.29          xtable_1.8-4          
## [103] httpuv_1.6.6           munsell_0.5.0          viridisLite_0.4.1     
## [106] bslib_0.4.0

END of report

Mitch Report

Antony Kaspi & Mark Ziemann

Background

Input profiles

Input genesets

Differential pathway expression

Interactive enrichment scatterplot

Results table

Results (complete table)

Detailed Gene set reports