Mitch Report

date generated: 2022-10-13

Background

Mitch performs unidimensional and multidimensional gene set enrichment analysis. The concept behind this dates to work by Cox and Mann (https://doi.org/10.1186/1471-2105-13-S16-S12). This implementation is suited to R based workflows of multi-omics datasets. This software was developed by Antony Kaspi and Mark Ziemann. Learn more about Mitch at the website: https://github.com/markziemann/Mitch

Input profiles

Here is the first few lines of the input profile.

##                        x
## 0610009B22Rik  0.5780015
## 0610009E02Rik  0.4394343
## 0610009L18Rik  1.4508124
## 0610010K14Rik  2.1194691
## 0610012G03Rik  2.6585547
## 0610030E20Rik -1.5015909

Here are some metrics about the input data profile:

Profile metrics

	Profile metrics
num_genesets	1604
num_genes_in_profile	17352
duplicated_genes_present	0
num_profile_genes_in_sets	8397
num_profile_genes_not_in_sets	8955

Here is a plot of the input profiles. Note the dynamic ranges.

Here is the contour plot of the profile including all detected genes.

Input genesets

Here are some metrics about the gene sets used: GMT file of genesets: mouse_msigdb_reactome_2022-02-16.gmt

Gene sets metrics

	Gene sets metrics
num_genesets	1604
num_genesets_excluded	424
num_genesets_included	1180

Differential pathway expression

Interactive enrichment scatterplot

Significance is calculated by -log10(p-value). All points shown are FDR<0.05.

Significance is calculated by -log10(p-value). Top N sets shown irrespective of FDR.

Results table

Top N= 50 gene sets

set	setSize	pANOVA	s.dist	p.adjustANOVA
EUKARYOTIC TRANSLATION ELONGATION	87	4.06e-44	0.862	1.60e-41
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	95	1.55e-37	0.759	1.83e-35
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.13e-41	0.759	2.66e-39
MITOCHONDRIAL TRANSLATION	93	3.00e-36	0.753	2.95e-34
EUKARYOTIC TRANSLATION INITIATION	114	1.77e-43	0.748	5.22e-41
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	4.11e-08	0.747	7.82e-07
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	4.94e-05	-0.741	4.38e-04
COMPLEX I BIOGENESIS	56	6.16e-21	0.725	3.64e-19
SELENOAMINO ACID METABOLISM	108	2.53e-38	0.720	3.32e-36
RESPIRATORY ELECTRON TRANSPORT	102	2.25e-34	0.700	2.04e-32
CRISTAE FORMATION	31	2.45e-11	0.692	8.28e-10
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	1.74e-40	0.689	2.93e-38
NONSENSE MEDIATED DECAY NMD	109	6.67e-34	0.672	5.62e-32
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	2.94e-05	-0.669	2.84e-04
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	1.24e-18	0.663	6.67e-17
MITOCHONDRIAL PROTEIN IMPORT	63	5.96e-19	0.647	3.35e-17
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	6.83e-05	0.638	5.80e-04
TRANSLATION	286	2.00e-73	0.621	2.36e-70
PKA MEDIATED PHOSPHORYLATION OF CREB	19	3.08e-06	-0.618	4.08e-05
RNA POLYMERASE III CHAIN ELONGATION	18	8.72e-06	0.605	9.99e-05
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.71e-40	0.588	2.93e-38
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	9.51e-14	0.586	4.31e-12
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	3.14e-05	-0.583	2.99e-04
REGULATION OF EXPRESSION OF SLITS AND ROBOS	162	1.75e-37	0.582	1.88e-35
CELLULAR RESPONSE TO STARVATION	146	1.09e-32	0.570	8.03e-31
METABOLISM OF POLYAMINES	57	1.07e-13	0.569	4.69e-12
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	1.15e-04	-0.557	8.79e-04
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	8.69e-11	0.553	2.63e-09
COHESIN LOADING ONTO CHROMATIN	10	2.69e-03	-0.548	1.29e-02
SIGNALING BY HIPPO	20	2.26e-05	-0.547	2.24e-04
RRNA PROCESSING	194	1.95e-39	0.546	2.87e-37
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	1.97e-03	0.539	9.88e-03
PROCESSING OF SMDT1	16	1.95e-04	0.538	1.36e-03
STABILIZATION OF P53	54	6.70e-11	0.513	2.08e-09
PINK1 PRKN MEDIATED MITOPHAGY	22	3.23e-05	0.512	3.03e-04
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	2.21e-05	0.511	2.21e-04
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	58	1.96e-11	0.509	7.22e-10
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	8.67e-05	-0.507	7.15e-04
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	66	1.33e-12	0.505	5.59e-11
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	2.78e-10	0.501	7.44e-09
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	6.37e-03	-0.498	2.59e-02
DEGRADATION OF DVL	55	1.84e-10	0.497	5.31e-09
PYROPTOSIS	20	1.28e-04	0.495	9.66e-04
PURINE CATABOLISM	16	6.45e-04	0.493	3.78e-03
METABOLISM OF AMINO ACIDS AND DERIVATIVES	317	1.02e-50	0.489	6.01e-48
ANTIMICROBIAL PEPTIDES	16	7.15e-04	0.489	4.10e-03
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	1.36e-11	0.485	5.36e-10
SIGNALING BY FGFR2 IIIA TM	19	2.66e-04	0.483	1.76e-03
INFLUENZA INFECTION	145	1.00e-23	0.483	6.95e-22
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	8.45e-03	-0.481	3.20e-02

---

Results (complete table)

Click HERE to show results for all gene sets

Complete results

set	setSize	pANOVA	s.dist	p.adjustANOVA
EUKARYOTIC TRANSLATION ELONGATION	87	4.06e-44	0.862000	1.60e-41
RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY	95	1.55e-37	0.759000	1.83e-35
SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	106	1.13e-41	0.759000	2.66e-39
MITOCHONDRIAL TRANSLATION	93	3.00e-36	0.753000	2.95e-34
EUKARYOTIC TRANSLATION INITIATION	114	1.77e-43	0.748000	5.22e-41
FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	18	4.11e-08	0.747000	7.82e-07
ADENYLATE CYCLASE ACTIVATING PATHWAY	10	4.94e-05	-0.741000	4.38e-04
COMPLEX I BIOGENESIS	56	6.16e-21	0.725000	3.64e-19
SELENOAMINO ACID METABOLISM	108	2.53e-38	0.720000	3.32e-36
RESPIRATORY ELECTRON TRANSPORT	102	2.25e-34	0.700000	2.04e-32
CRISTAE FORMATION	31	2.45e-11	0.692000	8.28e-10
RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	125	1.74e-40	0.689000	2.93e-38
NONSENSE MEDIATED DECAY NMD	109	6.67e-34	0.672000	5.62e-32
ADENYLATE CYCLASE INHIBITORY PATHWAY	13	2.94e-05	-0.669000	2.84e-04
ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	59	1.24e-18	0.663000	6.67e-17
MITOCHONDRIAL PROTEIN IMPORT	63	5.96e-19	0.647000	3.35e-17
MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS	13	6.83e-05	0.638000	5.80e-04
TRANSLATION	286	2.00e-73	0.621000	2.36e-70
PKA MEDIATED PHOSPHORYLATION OF CREB	19	3.08e-06	-0.618000	4.08e-05
RNA POLYMERASE III CHAIN ELONGATION	18	8.72e-06	0.605000	9.99e-05
THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT	172	1.71e-40	0.588000	2.93e-38
NEGATIVE REGULATION OF NOTCH4 SIGNALING	54	9.51e-14	0.586000	4.31e-12
REGULATION OF RUNX1 EXPRESSION AND ACTIVITY	17	3.14e-05	-0.583000	2.99e-04
REGULATION OF EXPRESSION OF SLITS AND ROBOS	162	1.75e-37	0.582000	1.88e-35
CELLULAR RESPONSE TO STARVATION	146	1.09e-32	0.570000	8.03e-31
METABOLISM OF POLYAMINES	57	1.07e-13	0.569000	4.69e-12
PKA ACTIVATION IN GLUCAGON SIGNALLING	16	1.15e-04	-0.557000	8.79e-04
CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	46	8.69e-11	0.553000	2.63e-09
COHESIN LOADING ONTO CHROMATIN	10	2.69e-03	-0.548000	1.29e-02
SIGNALING BY HIPPO	20	2.26e-05	-0.547000	2.24e-04
RRNA PROCESSING	194	1.95e-39	0.546000	2.87e-37
SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	11	1.97e-03	0.539000	9.88e-03
PROCESSING OF SMDT1	16	1.95e-04	0.538000	1.36e-03
STABILIZATION OF P53	54	6.70e-11	0.513000	2.08e-09
PINK1 PRKN MEDIATED MITOPHAGY	22	3.23e-05	0.512000	3.03e-04
ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT	23	2.21e-05	0.511000	2.21e-04
SCF SKP2 MEDIATED DEGRADATION OF P27 P21	58	1.96e-11	0.509000	7.22e-10
RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES	20	8.67e-05	-0.507000	7.15e-04
THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT	66	1.33e-12	0.505000	5.59e-11
REGULATION OF RUNX3 EXPRESSION AND ACTIVITY	53	2.78e-10	0.501000	7.44e-09
REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO	10	6.37e-03	-0.498000	2.59e-02
DEGRADATION OF DVL	55	1.84e-10	0.497000	5.31e-09
PYROPTOSIS	20	1.28e-04	0.495000	9.66e-04
PURINE CATABOLISM	16	6.45e-04	0.493000	3.78e-03
METABOLISM OF AMINO ACIDS AND DERIVATIVES	317	1.02e-50	0.489000	6.01e-48
ANTIMICROBIAL PEPTIDES	16	7.15e-04	0.489000	4.10e-03
ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	65	1.36e-11	0.485000	5.36e-10
SIGNALING BY FGFR2 IIIA TM	19	2.66e-04	0.483000	1.76e-03
INFLUENZA INFECTION	145	1.00e-23	0.483000	6.95e-22
ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS	10	8.45e-03	-0.481000	3.20e-02
DECTIN 1 MEDIATED NONCANONICAL NF KB SIGNALING	58	3.08e-10	0.478000	8.07e-09
MITOTIC TELOPHASE CYTOKINESIS	13	2.97e-03	-0.476000	1.39e-02
AUF1 HNRNP D0 BINDS AND DESTABILIZES MRNA	53	2.27e-09	0.475000	5.14e-08
CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE	11	6.56e-03	-0.473000	2.62e-02
TRANSLESION SYNTHESIS BY POLH	19	3.75e-04	0.471000	2.33e-03
INHIBITION OF DNA RECOMBINATION AT TELOMERE	35	1.57e-06	0.469000	2.24e-05
DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS	59	5.88e-10	0.466000	1.48e-08
APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	70	2.27e-11	0.462000	8.12e-10
REGULATION OF TLR BY ENDOGENOUS LIGAND	12	5.67e-03	0.461000	2.38e-02
ACTIVATION OF RAC1	13	4.00e-03	-0.461000	1.79e-02
SIGNALING BY ACTIVIN	12	5.72e-03	-0.461000	2.38e-02
RNA POLYMERASE III TRANSCRIPTION TERMINATION	23	1.31e-04	0.461000	9.84e-04
DEGRADATION OF AXIN	53	7.07e-09	0.460000	1.46e-07
CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	11	8.81e-03	-0.456000	3.29e-02
CITRIC ACID CYCLE TCA CYCLE	22	2.41e-04	0.452000	1.63e-03
RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE	22	2.46e-04	0.451000	1.66e-03
G1 S DNA DAMAGE CHECKPOINTS	64	4.84e-10	0.450000	1.24e-08
TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS	18	9.84e-04	-0.449000	5.38e-03
CA DEPENDENT EVENTS	36	3.43e-06	-0.447000	4.49e-05
DEGRADATION OF GLI1 BY THE PROTEASOME	57	6.42e-09	0.444000	1.35e-07
TRAF6 MEDIATED IRF7 ACTIVATION	15	2.93e-03	-0.444000	1.38e-02
REGULATION OF HMOX1 EXPRESSION AND ACTIVITY	63	1.17e-09	0.443000	2.82e-08
TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	13	5.75e-03	-0.442000	2.38e-02
SIGNALING BY BMP	25	1.38e-04	-0.440000	1.02e-03
INTERLEUKIN RECEPTOR SHC SIGNALING	20	6.61e-04	-0.440000	3.86e-03
AMINE LIGAND BINDING RECEPTORS	29	4.19e-05	-0.440000	3.80e-04
DETOXIFICATION OF REACTIVE OXYGEN SPECIES	32	1.72e-05	0.439000	1.76e-04
FORMATION OF THE EARLY ELONGATION COMPLEX	33	1.29e-05	0.439000	1.38e-04
PROTEIN LOCALIZATION	158	4.81e-21	0.434000	2.99e-19
MITOCHONDRIAL CALCIUM ION TRANSPORT	23	3.55e-04	0.430000	2.26e-03
REGULATION OF MECP2 EXPRESSION AND ACTIVITY	29	6.15e-05	-0.430000	5.34e-04
PURINE SALVAGE	12	1.02e-02	0.429000	3.68e-02
ORC1 REMOVAL FROM CHROMATIN	67	1.42e-09	0.428000	3.35e-08
GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION	26	1.66e-04	0.427000	1.19e-03
PCNA DEPENDENT LONG PATCH BASE EXCISION REPAIR	21	7.40e-04	0.425000	4.22e-03
DEACTIVATION OF THE BETA CATENIN TRANSACTIVATING COMPLEX	41	2.54e-06	-0.425000	3.49e-05
SEROTONIN RECEPTORS	10	2.20e-02	-0.418000	6.78e-02
RHOV GTPASE CYCLE	33	3.23e-05	-0.418000	3.03e-04
MITOCHONDRIAL FATTY ACID BETA OXIDATION	33	3.33e-05	0.417000	3.07e-04
MITOPHAGY	29	1.01e-04	0.417000	7.96e-04
POLYMERASE SWITCHING	14	7.03e-03	0.416000	2.77e-02
INTERACTION BETWEEN L1 AND ANKYRINS	27	1.83e-04	-0.416000	1.29e-03
NF KB ACTIVATION THROUGH FADD RIP 1 PATHWAY MEDIATED BY CASPASE 8 AND 10	11	1.74e-02	-0.414000	5.70e-02
DNA REPLICATION PRE INITIATION	81	1.28e-10	0.413000	3.78e-09
TRANSLESION SYNTHESIS BY POLK	17	3.36e-03	0.411000	1.54e-02
REPRESSION OF WNT TARGET GENES	14	7.83e-03	-0.411000	3.01e-02
APC C MEDIATED DEGRADATION OF CELL CYCLE PROTEINS	81	1.89e-10	0.409000	5.31e-09
RAS PROCESSING	24	5.34e-04	0.408000	3.18e-03
ENDOSOMAL VACUOLAR PATHWAY	11	1.91e-02	0.408000	6.08e-02
FCGR3A MEDIATED IL10 SYNTHESIS	32	6.56e-05	-0.408000	5.61e-04
ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE 3 KINASE PI3K	11	1.93e-02	-0.407000	6.11e-02
METHYLATION	11	1.95e-02	0.407000	6.16e-02
GENE AND PROTEIN EXPRESSION BY JAK STAT SIGNALING AFTER INTERLEUKIN 12 STIMULATION	31	9.14e-05	0.406000	7.39e-04
SIGNALING BY CTNNB1 PHOSPHO SITE MUTANTS	15	6.55e-03	-0.405000	2.62e-02
DEGRADATION OF CYSTEINE AND HOMOCYSTEINE	14	8.84e-03	0.404000	3.29e-02
SIGNALING BY WNT IN CANCER	31	1.07e-04	-0.402000	8.33e-04
CELLULAR RESPONSE TO HYPOXIA	72	4.00e-09	0.401000	8.59e-08
GLUTATHIONE CONJUGATION	30	1.55e-04	0.399000	1.13e-03
SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	16	5.76e-03	-0.399000	2.38e-02
PROTEIN PROTEIN INTERACTIONS AT SYNAPSES	85	2.16e-10	-0.398000	5.93e-09
PROTEIN METHYLATION	17	4.55e-03	0.397000	2.00e-02
BASE EXCISION REPAIR AP SITE FORMATION	29	2.27e-04	0.396000	1.55e-03
SODIUM CALCIUM EXCHANGERS	10	3.06e-02	-0.395000	8.67e-02
INSERTION OF TAIL ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE	22	1.36e-03	0.395000	6.97e-03
ANTIGEN PROCESSING CROSS PRESENTATION	96	2.42e-11	0.394000	8.28e-10
PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING	11	2.41e-02	-0.393000	7.23e-02
RNA POLYMERASE I PROMOTER ESCAPE	47	3.77e-06	0.390000	4.86e-05
NEUREXINS AND NEUROLIGINS	54	7.32e-07	-0.390000	1.08e-05
OTHER SEMAPHORIN INTERACTIONS	19	3.39e-03	-0.388000	1.55e-02
HEDGEHOG LIGAND BIOGENESIS	61	1.65e-07	0.388000	2.91e-06
ADHERENS JUNCTIONS INTERACTIONS	31	1.90e-04	-0.387000	1.33e-03
NEGATIVE REGULATION OF TCF DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS	11	2.64e-02	-0.387000	7.68e-02
RORA ACTIVATES GENE EXPRESSION	18	4.51e-03	-0.387000	1.99e-02
SIGNALING BY ROBO RECEPTORS	207	1.53e-21	0.384000	1.00e-19
MRNA CAPPING	29	3.71e-04	0.382000	2.32e-03
SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE	86	9.41e-10	0.382000	2.31e-08
REGULATION OF PTEN STABILITY AND ACTIVITY	66	8.26e-08	0.382000	1.50e-06
DAG AND IP3 SIGNALING	40	3.02e-05	-0.381000	2.90e-04
METABOLISM OF COFACTORS	19	4.10e-03	0.380000	1.83e-02
RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS	83	2.54e-09	0.378000	5.66e-08
SYNAPTIC ADHESION LIKE MOLECULES	21	2.69e-03	-0.378000	1.29e-02
ASYMMETRIC LOCALIZATION OF PCP PROTEINS	62	2.68e-07	0.378000	4.45e-06
PI3K EVENTS IN ERBB2 SIGNALING	15	1.20e-02	-0.375000	4.22e-02
ERBB2 ACTIVATES PTK6 SIGNALING	11	3.14e-02	-0.375000	8.88e-02
ESTROGEN DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR MEMBRANE SIGNALING	21	3.04e-03	-0.374000	1.41e-02
FORMATION OF TC NER PRE INCISION COMPLEX	53	2.58e-06	0.373000	3.50e-05
RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	25	1.28e-03	0.372000	6.68e-03
COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING	26	1.03e-03	0.372000	5.59e-03
CELLULAR RESPONSE TO CHEMICAL STRESS	150	4.78e-15	0.371000	2.25e-13
DNA DAMAGE RECOGNITION IN GG NER	38	7.93e-05	0.370000	6.64e-04
MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS	18	6.69e-03	-0.369000	2.67e-02
RUNX2 REGULATES BONE DEVELOPMENT	29	5.86e-04	-0.369000	3.48e-03
NEPHRIN FAMILY INTERACTIONS	21	3.44e-03	-0.369000	1.55e-02
RHOF GTPASE CYCLE	40	5.46e-05	-0.369000	4.80e-04
POST CHAPERONIN TUBULIN FOLDING PATHWAY	17	8.58e-03	0.368000	3.23e-02
SYNTHESIS OF PROSTAGLANDINS PG AND THROMBOXANES TX	13	2.16e-02	0.368000	6.66e-02
SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS	18	6.91e-03	-0.368000	2.73e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	28	7.81e-04	0.367000	4.39e-03
SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	11	3.54e-02	-0.366000	9.52e-02
CRMPS IN SEMA3A SIGNALING	16	1.15e-02	-0.365000	4.10e-02
BASE EXCISION REPAIR	57	1.87e-06	0.365000	2.60e-05
G PROTEIN MEDIATED EVENTS	52	5.53e-06	-0.364000	6.73e-05
ABC TRANSPORTER DISORDERS	69	1.77e-07	0.364000	3.08e-06
RRNA PROCESSING IN THE MITOCHONDRION	10	4.68e-02	0.363000	1.17e-01
RND3 GTPASE CYCLE	38	1.09e-04	-0.363000	8.44e-04
REGULATION OF RAS BY GAPS	66	4.43e-07	0.359000	6.80e-06
APC CDC20 MEDIATED DEGRADATION OF NEK2A	25	1.96e-03	0.358000	9.88e-03
GLUCONEOGENESIS	27	1.30e-03	0.358000	6.71e-03
DNA REPLICATION	122	9.20e-12	0.357000	3.74e-10
TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX	12	3.37e-02	0.354000	9.27e-02
CYTOPROTECTION BY HMOX1	119	2.59e-11	0.354000	8.49e-10
BETA CATENIN PHOSPHORYLATION CASCADE	16	1.53e-02	-0.350000	5.13e-02
RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER	28	1.35e-03	0.350000	6.97e-03
RNA POLYMERASE I TRANSCRIPTION TERMINATION	31	7.72e-04	0.349000	4.36e-03
HIV TRANSCRIPTION ELONGATION	42	9.44e-05	0.348000	7.55e-04
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	15	1.97e-02	0.348000	6.22e-02
RHOU GTPASE CYCLE	34	4.71e-04	-0.347000	2.86e-03
REGULATION OF RUNX2 EXPRESSION AND ACTIVITY	69	6.51e-07	0.346000	9.84e-06
ATTENUATION PHASE	24	3.33e-03	-0.346000	1.53e-02
CYCLIN A CDK2 ASSOCIATED EVENTS AT S PHASE ENTRY	83	5.56e-08	0.345000	1.04e-06
APOPTOTIC FACTOR MEDIATED RESPONSE	18	1.22e-02	0.341000	4.27e-02
ACTIVATION OF GENE EXPRESSION BY SREBF SREBP	43	1.09e-04	-0.341000	8.44e-04
DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	78	1.96e-07	0.341000	3.36e-06
HEME SIGNALING	45	8.19e-05	-0.339000	6.80e-04
RESOLUTION OF ABASIC SITES AP SITES	38	3.08e-04	0.338000	2.01e-03
SEALING OF THE NUCLEAR ENVELOPE NE BY ESCRT III	23	5.06e-03	0.338000	2.20e-02
FCERI MEDIATED NF KB ACTIVATION	76	3.68e-07	0.337000	5.80e-06
UCH PROTEINASES	89	3.82e-08	0.337000	7.39e-07
COMMON PATHWAY OF FIBRIN CLOT FORMATION	10	6.49e-02	0.337000	1.49e-01
NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	23	5.14e-03	-0.337000	2.22e-02
BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION	25	3.61e-03	-0.336000	1.63e-02
PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	51	3.33e-05	0.336000	3.07e-04
SEMA3A PAK DEPENDENT AXON REPULSION	16	2.01e-02	-0.336000	6.30e-02
MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	31	1.25e-03	-0.335000	6.51e-03
INTERLEUKIN 12 SIGNALING	37	4.46e-04	0.334000	2.73e-03
LONG TERM POTENTIATION	23	5.63e-03	-0.334000	2.38e-02
REGULATION OF GENE EXPRESSION IN LATE STAGE BRANCHING MORPHOGENESIS PANCREATIC BUD PRECURSOR CELLS	15	2.56e-02	-0.333000	7.60e-02
SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER	15	2.58e-02	-0.333000	7.62e-02
TNFR2 NON CANONICAL NF KB PATHWAY	78	4.44e-07	0.331000	6.80e-06
PIWI INTERACTING RNA PIRNA BIOGENESIS	20	1.08e-02	0.329000	3.89e-02
LAGGING STRAND SYNTHESIS	20	1.09e-02	0.329000	3.90e-02
APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	21	9.41e-03	0.327000	3.47e-02
FGFR2 MUTANT RECEPTOR ACTIVATION	28	2.73e-03	0.327000	1.30e-02
DNA METHYLATION	20	1.14e-02	0.327000	4.09e-02
BUDDING AND MATURATION OF HIV VIRION	27	3.41e-03	0.326000	1.55e-02
EPHRIN SIGNALING	19	1.41e-02	-0.325000	4.83e-02
REDUCTION OF CYTOSOLIC CA LEVELS	11	6.20e-02	-0.325000	1.44e-01
NEUROTRANSMITTER CLEARANCE	10	7.56e-02	0.324000	1.67e-01
MRNA SPLICING MINOR PATHWAY	52	5.81e-05	0.322000	5.08e-04
ABC TRANSPORTERS IN LIPID HOMEOSTASIS	13	4.46e-02	-0.322000	1.14e-01
NCAM SIGNALING FOR NEURITE OUT GROWTH	61	1.41e-05	-0.322000	1.47e-04
SULFUR AMINO ACID METABOLISM	25	5.68e-03	0.320000	2.38e-02
FGFRL1 MODULATION OF FGFR1 SIGNALING	11	6.70e-02	-0.319000	1.52e-01
LYSOSPHINGOLIPID AND LPA RECEPTORS	13	4.65e-02	-0.319000	1.17e-01
HIV TRANSCRIPTION INITIATION	45	2.17e-04	0.319000	1.49e-03
TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR TC NER	78	1.36e-06	0.316000	1.96e-05
BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS	11	6.95e-02	0.316000	1.56e-01
SIGNALING BY NOTCH4	83	6.76e-07	0.316000	1.01e-05
DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS	18	2.08e-02	0.315000	6.46e-02
DUAL INCISION IN TC NER	65	1.15e-05	0.315000	1.25e-04
GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	5.93e-02	-0.314000	1.39e-01
GAB1 SIGNALOSOME	14	4.20e-02	-0.314000	1.10e-01
PLATELET SENSITIZATION BY LDL	15	3.72e-02	-0.311000	9.87e-02
RND2 GTPASE CYCLE	39	8.01e-04	-0.310000	4.48e-03
PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	16	3.18e-02	0.310000	8.91e-02
DNA STRAND ELONGATION	32	2.52e-03	0.309000	1.23e-02
TRANSCRIPTIONAL REGULATION BY MECP2	59	4.57e-05	-0.307000	4.12e-04
FORMATION OF FIBRIN CLOT CLOTTING CASCADE	20	1.77e-02	0.306000	5.76e-02
HIV ELONGATION ARREST AND RECOVERY	32	2.71e-03	0.306000	1.29e-02
DUAL INCISION IN GG NER	41	6.90e-04	0.306000	3.99e-03
GAP FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG NER	25	8.03e-03	0.306000	3.08e-02
ACTIVATION OF SMO	16	3.44e-02	-0.305000	9.40e-02
TFAP2 AP 2 FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS	11	7.95e-02	-0.305000	1.74e-01
NRAGE SIGNALS DEATH THROUGH JNK	55	9.12e-05	-0.305000	7.39e-04
INTERLEUKIN 2 FAMILY SIGNALING	33	2.43e-03	-0.305000	1.20e-02
NUCLEOTIDE SALVAGE	21	1.56e-02	0.305000	5.19e-02
INTERLEUKIN 1 SIGNALING	95	3.03e-07	0.304000	4.90e-06
SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION	24	9.94e-03	0.304000	3.65e-02
PEROXISOMAL LIPID METABOLISM	26	7.33e-03	0.304000	2.85e-02
LATE ENDOSOMAL MICROAUTOPHAGY	32	3.09e-03	0.302000	1.42e-02
BRANCHED CHAIN AMINO ACID CATABOLISM	21	1.72e-02	0.300000	5.67e-02
RECEPTOR MEDIATED MITOPHAGY	11	8.48e-02	0.300000	1.83e-01
ERBB2 REGULATES CELL MOTILITY	14	5.23e-02	-0.300000	1.28e-01
NCAM1 INTERACTIONS	41	9.30e-04	-0.299000	5.13e-03
UNBLOCKING OF NMDA RECEPTORS GLUTAMATE BINDING AND ACTIVATION	21	1.80e-02	-0.298000	5.83e-02
MTORC1 MEDIATED SIGNALLING	24	1.17e-02	0.297000	4.15e-02
TELOMERE MAINTENANCE	77	6.46e-06	0.297000	7.62e-05
METABOLISM OF FOLATE AND PTERINES	15	4.64e-02	0.297000	1.17e-01
INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	29	5.69e-03	0.297000	2.38e-02
PHASE II CONJUGATION OF COMPOUNDS	63	4.68e-05	0.297000	4.19e-04
RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION	23	1.40e-02	-0.296000	4.81e-02
REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP SREBF	56	1.32e-04	-0.295000	9.84e-04
PREGNENOLONE BIOSYNTHESIS	12	7.66e-02	0.295000	1.69e-01
RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	59	8.93e-05	0.295000	7.32e-04
INSULIN RECEPTOR RECYCLING	20	2.26e-02	0.295000	6.88e-02
INTERLEUKIN 3 INTERLEUKIN 5 AND GM CSF SIGNALING	41	1.11e-03	-0.294000	5.93e-03
INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	20	2.28e-02	0.294000	6.93e-02
DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	23	1.53e-02	-0.292000	5.14e-02
ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	30	5.70e-03	0.292000	2.38e-02
JOSEPHIN DOMAIN DUBS	11	9.45e-02	0.291000	1.98e-01
NUCLEOTIDE EXCISION REPAIR	110	1.50e-07	0.290000	2.67e-06
METABOLISM OF STEROID HORMONES	22	1.91e-02	0.289000	6.08e-02
RAC1 GTPASE CYCLE	178	3.30e-11	-0.288000	1.05e-09
RECOGNITION OF DNA DAMAGE BY PCNA CONTAINING REPLICATION COMPLEX	30	6.41e-03	0.288000	2.59e-02
GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR GG NER	84	5.30e-06	0.287000	6.51e-05
NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	11	9.91e-02	-0.287000	2.05e-01
MISCELLANEOUS TRANSPORT AND BINDING EVENTS	21	2.30e-02	-0.287000	6.98e-02
REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	5.88e-06	0.286000	7.08e-05
TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	43	1.25e-03	-0.285000	6.51e-03
CD209 DC SIGN SIGNALING	18	3.67e-02	-0.284000	9.82e-02
FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	19	3.24e-02	0.284000	9.04e-02
SCAVENGING OF HEME FROM PLASMA	11	1.04e-01	0.283000	2.10e-01
SEROTONIN NEUROTRANSMITTER RELEASE CYCLE	18	3.77e-02	-0.283000	9.97e-02
SIGNALING BY ERBB2 IN CANCER	25	1.45e-02	-0.283000	4.93e-02
MET ACTIVATES RAP1 AND RAC1	11	1.05e-01	-0.282000	2.12e-01
FGFR2 ALTERNATIVE SPLICING	25	1.49e-02	0.281000	5.05e-02
N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	24	1.71e-02	-0.281000	5.65e-02
SIGNALING BY FGFR1 IN DISEASE	34	4.62e-03	-0.281000	2.02e-02
GABA RECEPTOR ACTIVATION	54	3.70e-04	-0.280000	2.32e-03
NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	65	9.60e-05	0.280000	7.60e-04
SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	15	6.13e-02	-0.279000	1.43e-01
INTERLEUKIN 6 SIGNALING	10	1.27e-01	-0.278000	2.46e-01
VXPX CARGO TARGETING TO CILIUM	19	3.61e-02	-0.278000	9.68e-02
PKMTS METHYLATE HISTONE LYSINES	49	8.11e-04	-0.277000	4.52e-03
METABOLISM OF RNA	645	6.52e-33	0.276000	5.13e-31
CDC42 GTPASE CYCLE	154	3.49e-09	-0.276000	7.63e-08
SIGNALING BY PDGFR IN DISEASE	20	3.30e-02	-0.275000	9.11e-02
REGULATION OF BACH1 ACTIVITY	11	1.14e-01	0.275000	2.26e-01
STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES	14	7.47e-02	-0.275000	1.65e-01
NOTCH HLH TRANSCRIPTION PATHWAY	28	1.18e-02	-0.275000	4.16e-02
CELL CELL JUNCTION ORGANIZATION	48	9.92e-04	-0.275000	5.39e-03
UNWINDING OF DNA	12	1.00e-01	0.274000	2.06e-01
DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	23	2.31e-02	-0.274000	7.00e-02
SIGNALING BY FGFR4 IN DISEASE	10	1.35e-01	-0.273000	2.56e-01
IRAK4 DEFICIENCY TLR2 4	13	8.89e-02	0.273000	1.90e-01
DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	36	4.73e-03	0.272000	2.06e-02
FGFR1 MUTANT RECEPTOR ACTIVATION	27	1.45e-02	-0.272000	4.93e-02
CLEC7A DECTIN 1 SIGNALING	93	6.43e-06	0.271000	7.62e-05
RUNX3 REGULATES NOTCH SIGNALING	13	9.22e-02	-0.270000	1.95e-01
P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	12	1.07e-01	-0.269000	2.16e-01
G BETA GAMMA SIGNALLING THROUGH CDC42	18	4.94e-02	0.268000	1.21e-01
REGULATION OF GLYCOLYSIS BY FRUCTOSE 2 6 BISPHOSPHATE METABOLISM	10	1.43e-01	-0.268000	2.68e-01
ACTIVATION OF MATRIX METALLOPROTEINASES	15	7.35e-02	-0.267000	1.63e-01
DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE	27	1.64e-02	-0.267000	5.42e-02
PCP CE PATHWAY	89	1.35e-05	0.267000	1.44e-04
TRIGLYCERIDE CATABOLISM	14	8.38e-02	0.267000	1.82e-01
ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR ANDROGEN RECEPTOR REGULATED GENES KLK2 AND KLK3	21	3.45e-02	0.267000	9.40e-02
STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS	10	1.45e-01	0.266000	2.70e-01
LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME	13	9.73e-02	-0.266000	2.02e-01
SIGNALING BY NTRK2 TRKB	24	2.44e-02	-0.265000	7.31e-02
AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS	10	1.47e-01	-0.265000	2.73e-01
PEROXISOMAL PROTEIN IMPORT	59	4.36e-04	0.265000	2.68e-03
RHOD GTPASE CYCLE	51	1.12e-03	-0.264000	5.97e-03
SIGNALING BY FLT3 FUSION PROTEINS	19	4.72e-02	-0.263000	1.18e-01
INTERLEUKIN 12 FAMILY SIGNALING	43	2.85e-03	0.263000	1.34e-02
IRF3 MEDIATED INDUCTION OF TYPE I IFN	11	1.32e-01	-0.263000	2.52e-01
REGULATED NECROSIS	45	2.38e-03	0.262000	1.18e-02
SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	14	9.05e-02	-0.261000	1.92e-01
N GLYCAN ANTENNAE ELONGATION	15	8.36e-02	-0.258000	1.81e-01
GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION	11	1.38e-01	0.258000	2.61e-01
NR1H2 AND NR1H3 MEDIATED SIGNALING	38	5.95e-03	-0.258000	2.45e-02
AMYLOID FIBER FORMATION	57	7.62e-04	0.258000	4.32e-03
PHASE 0 RAPID DEPOLARISATION	28	1.84e-02	-0.258000	5.92e-02
VEGFR2 MEDIATED VASCULAR PERMEABILITY	27	2.11e-02	-0.256000	6.54e-02
CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR MEDIATED ACTIVATION OF RAS SIGNALING	28	1.90e-02	-0.256000	6.08e-02
INTERLEUKIN 15 SIGNALING	13	1.10e-01	-0.256000	2.21e-01
INTERLEUKIN 7 SIGNALING	19	5.36e-02	-0.256000	1.31e-01
POLYMERASE SWITCHING ON THE C STRAND OF THE TELOMERE	25	2.70e-02	0.256000	7.81e-02
CHROMOSOME MAINTENANCE	99	1.16e-05	0.255000	1.26e-04
SYNTHESIS OF IP2 IP AND INS IN THE CYTOSOL	13	1.11e-01	-0.255000	2.22e-01
B WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION	47	2.50e-03	0.255000	1.22e-02
HSF1 DEPENDENT TRANSACTIVATION	34	1.01e-02	-0.255000	3.67e-02
SHC1 EVENTS IN ERBB2 SIGNALING	21	4.32e-02	-0.255000	1.12e-01
TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL	43	3.96e-03	0.254000	1.78e-02
S PHASE	154	5.64e-08	0.254000	1.04e-06
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	12	1.29e-01	-0.253000	2.49e-01
METABOLISM OF NUCLEOTIDES	92	2.91e-05	0.252000	2.84e-04
TRANSFERRIN ENDOCYTOSIS AND RECYCLING	26	2.63e-02	0.252000	7.68e-02
RND1 GTPASE CYCLE	38	7.33e-03	-0.251000	2.85e-02
RHOC GTPASE CYCLE	74	2.04e-04	-0.250000	1.41e-03
RHOA GTPASE CYCLE	144	2.49e-07	-0.249000	4.19e-06
RHOQ GTPASE CYCLE	59	9.40e-04	-0.249000	5.16e-03
SIGNALING BY NOTCH1	75	1.93e-04	-0.249000	1.35e-03
MITOTIC G1 PHASE AND G1 S TRANSITION	142	3.14e-07	0.249000	5.01e-06
CYTOSOLIC TRNA AMINOACYLATION	24	3.50e-02	0.249000	9.48e-02
RHOB GTPASE CYCLE	69	3.58e-04	-0.249000	2.27e-03
NEGATIVE REGULATION OF NMDA RECEPTOR MEDIATED NEURONAL TRANSMISSION	21	4.87e-02	-0.248000	1.20e-01
HOST INTERACTIONS OF HIV FACTORS	124	1.84e-06	0.248000	2.58e-05
PYRUVATE METABOLISM	27	2.60e-02	0.247000	7.64e-02
CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	19	6.19e-02	0.247000	1.44e-01
TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS	11	1.55e-01	-0.247000	2.84e-01
CHAPERONE MEDIATED AUTOPHAGY	21	4.99e-02	0.247000	1.22e-01
SELECTIVE AUTOPHAGY	72	2.95e-04	0.247000	1.94e-03
CIRCADIAN CLOCK	67	4.97e-04	-0.246000	2.99e-03
NUCLEOBASE CATABOLISM	31	1.78e-02	0.246000	5.77e-02
G2 M CHECKPOINTS	133	9.78e-07	0.246000	1.42e-05
SIGNALING BY ERYTHROPOIETIN	24	3.70e-02	-0.246000	9.86e-02
PECAM1 INTERACTIONS	12	1.42e-01	-0.245000	2.66e-01
RNA POLYMERASE III TRANSCRIPTION	41	6.76e-03	0.244000	2.69e-02
RHOBTB2 GTPASE CYCLE	23	4.33e-02	-0.243000	1.12e-01
CELL CELL COMMUNICATION	103	2.08e-05	-0.243000	2.09e-04
FORMATION OF INCISION COMPLEX IN GG NER	43	6.00e-03	0.242000	2.46e-02
TERMINATION OF TRANSLESION DNA SYNTHESIS	32	1.80e-02	0.242000	5.83e-02
CELL JUNCTION ORGANIZATION	72	3.98e-04	-0.241000	2.46e-03
ONCOGENIC MAPK SIGNALING	77	2.55e-04	-0.241000	1.71e-03
TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE	39	9.32e-03	0.241000	3.46e-02
LAMININ INTERACTIONS	29	2.59e-02	-0.239000	7.63e-02
BIOLOGICAL OXIDATIONS	126	3.79e-06	0.239000	4.86e-05
GABA B RECEPTOR ACTIVATION	39	1.01e-02	-0.238000	3.66e-02
PRC2 METHYLATES HISTONES AND DNA	29	2.66e-02	0.238000	7.73e-02
GAP JUNCTION ASSEMBLY	21	5.92e-02	0.238000	1.39e-01
TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES	37	1.24e-02	0.238000	4.33e-02
RHO GTPASES ACTIVATE KTN1	11	1.73e-01	0.238000	3.08e-01
KSRP KHSRP BINDS AND DESTABILIZES MRNA	16	1.02e-01	0.236000	2.09e-01
HS GAG BIOSYNTHESIS	30	2.54e-02	-0.236000	7.55e-02
EGR2 AND SOX10 MEDIATED INITIATION OF SCHWANN CELL MYELINATION	26	3.82e-02	-0.235000	1.01e-01
NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	20	6.90e-02	-0.235000	1.55e-01
PROCESSING AND ACTIVATION OF SUMO	10	1.99e-01	0.235000	3.39e-01
RNA POLYMERASE I TRANSCRIPTION	67	9.12e-04	0.234000	5.05e-03
CONDENSATION OF PROPHASE CHROMOSOMES	27	3.52e-02	0.234000	9.50e-02
MATURATION OF NUCLEOPROTEIN	10	2.03e-01	-0.233000	3.43e-01
NUCLEOTIDE LIKE PURINERGIC RECEPTORS	13	1.48e-01	-0.232000	2.74e-01
NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	16	1.08e-01	0.232000	2.17e-01
NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	44	7.80e-03	-0.232000	3.01e-02
INTERLEUKIN 1 FAMILY SIGNALING	121	1.07e-05	0.232000	1.18e-04
TCR SIGNALING	100	6.26e-05	0.232000	5.39e-04
SIGNALING BY RETINOIC ACID	31	2.59e-02	0.231000	7.63e-02
TELOMERE C STRAND SYNTHESIS INITIATION	13	1.51e-01	0.230000	2.78e-01
L1CAM INTERACTIONS	107	3.95e-05	-0.230000	3.61e-04
ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS	23	5.62e-02	0.230000	1.35e-01
PROTEIN FOLDING	89	1.82e-04	0.230000	1.29e-03
PHOSPHORYLATION OF THE APC C	17	1.02e-01	0.229000	2.09e-01
CA2 PATHWAY	56	3.09e-03	-0.229000	1.42e-02
TRANSCRIPTION OF THE HIV GENOME	67	1.24e-03	0.228000	6.51e-03
ASSEMBLY OF THE HIV VIRION	16	1.14e-01	0.228000	2.27e-01
DCC MEDIATED ATTRACTIVE SIGNALING	14	1.41e-01	-0.227000	2.64e-01
MEIOTIC RECOMBINATION	40	1.30e-02	0.227000	4.51e-02
SEMAPHORIN INTERACTIONS	64	1.72e-03	-0.227000	8.74e-03
RET SIGNALING	37	1.74e-02	-0.226000	5.70e-02
VEGFR2 MEDIATED CELL PROLIFERATION	19	8.88e-02	-0.226000	1.90e-01
ABC FAMILY PROTEINS MEDIATED TRANSPORT	94	1.62e-04	0.225000	1.17e-03
CONSTITUTIVE SIGNALING BY EGFRVIII	15	1.31e-01	-0.225000	2.51e-01
RHO GTPASE CYCLE	425	2.49e-15	-0.224000	1.23e-13
HEME BIOSYNTHESIS	13	1.63e-01	0.223000	2.95e-01
REGULATION OF BETA CELL DEVELOPMENT	30	3.45e-02	-0.223000	9.40e-02
AGGREPHAGY	35	2.24e-02	0.223000	6.87e-02
GLUTATHIONE SYNTHESIS AND RECYCLING	11	2.01e-01	0.223000	3.42e-01
RA BIOSYNTHESIS PATHWAY	12	1.83e-01	0.222000	3.19e-01
SIGNALING BY BRAF AND RAF FUSIONS	60	2.97e-03	-0.222000	1.39e-02
TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN	20	8.67e-02	-0.221000	1.87e-01
HIV INFECTION	220	1.59e-08	0.221000	3.19e-07
PYRIMIDINE CATABOLISM	10	2.26e-01	0.221000	3.72e-01
ANCHORING FIBRIL FORMATION	15	1.39e-01	-0.221000	2.61e-01
AUTOPHAGY	139	7.07e-06	0.221000	8.18e-05
DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX	82	5.98e-04	0.219000	3.53e-03
NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	48	8.59e-03	-0.219000	3.23e-02
SIGNAL TRANSDUCTION BY L1	21	8.27e-02	-0.219000	1.80e-01
FCERI MEDIATED MAPK ACTIVATION	28	4.53e-02	-0.219000	1.15e-01
TP53 REGULATES METABOLIC GENES	85	5.00e-04	0.218000	2.99e-03
INSULIN PROCESSING	24	6.41e-02	-0.218000	1.47e-01
MYOGENESIS	24	6.43e-02	-0.218000	1.48e-01
INTEGRIN SIGNALING	24	6.51e-02	-0.218000	1.49e-01
PI 3K CASCADE FGFR4	13	1.75e-01	-0.217000	3.11e-01
RHOJ GTPASE CYCLE	55	5.52e-03	-0.216000	2.37e-02
THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	22	7.94e-02	0.216000	1.74e-01
ROS AND RNS PRODUCTION IN PHAGOCYTES	29	4.42e-02	0.216000	1.13e-01
RESPONSE OF EIF2AK1 HRI TO HEME DEFICIENCY	15	1.48e-01	0.216000	2.74e-01
SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	52	7.24e-03	-0.215000	2.83e-02
TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	83	7.15e-04	-0.215000	4.10e-03
SIGNALING BY TGFB FAMILY MEMBERS	97	2.60e-04	-0.215000	1.74e-03
GLUTAMATE AND GLUTAMINE METABOLISM	13	1.82e-01	0.214000	3.18e-01
AMINO ACIDS REGULATE MTORC1	51	8.34e-03	0.214000	3.17e-02
GROWTH HORMONE RECEPTOR SIGNALING	20	9.92e-02	-0.213000	2.05e-01
PHASE 2 PLATEAU PHASE	11	2.22e-01	-0.213000	3.68e-01
ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA	15	1.56e-01	0.212000	2.85e-01
NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	21	9.41e-02	-0.211000	1.98e-01
ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION	14	1.72e-01	-0.211000	3.07e-01
PI METABOLISM	80	1.10e-03	-0.211000	5.92e-03
RHOBTB GTPASE CYCLE	35	3.16e-02	-0.210000	8.89e-02
NF KB IS ACTIVATED AND SIGNALS SURVIVAL	12	2.09e-01	0.209000	3.52e-01
VOLTAGE GATED POTASSIUM CHANNELS	39	2.38e-02	-0.209000	7.18e-02
METABOLISM OF PORPHYRINS	19	1.15e-01	0.209000	2.27e-01
SEPARATION OF SISTER CHROMATIDS	168	3.04e-06	0.209000	4.07e-05
SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER	59	5.53e-03	-0.209000	2.37e-02
GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	30	4.78e-02	0.209000	1.19e-01
ANTIGEN ACTIVATES B CELL RECEPTOR BCR LEADING TO GENERATION OF SECOND MESSENGERS	26	6.56e-02	-0.209000	1.49e-01
PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS	19	1.17e-01	0.208000	2.29e-01
SUMOYLATION OF TRANSCRIPTION COFACTORS	42	1.98e-02	-0.208000	6.24e-02
GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	14	1.78e-01	-0.208000	3.14e-01
ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	32	4.22e-02	-0.208000	1.10e-01
KILLING MECHANISMS	10	2.57e-01	-0.207000	4.07e-01
APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	33	3.95e-02	-0.207000	1.04e-01
REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO FACTORS	14	1.80e-01	-0.207000	3.16e-01
GLUCAGON SIGNALING IN METABOLIC REGULATION	29	5.43e-02	-0.207000	1.32e-01
PEXOPHAGY	11	2.37e-01	0.206000	3.85e-01
FREE FATTY ACIDS REGULATE INSULIN SECRETION	10	2.60e-01	-0.206000	4.08e-01
TRANSCRIPTIONAL REGULATION BY VENTX	35	3.54e-02	-0.205000	9.52e-02
IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	10	2.62e-01	-0.205000	4.10e-01
TRISTETRAPROLIN TTP ZFP36 BINDS AND DESTABILIZES MRNA	16	1.56e-01	0.205000	2.85e-01
SIGNALING BY NTRK3 TRKC	17	1.44e-01	-0.205000	2.69e-01
TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	11	2.40e-01	0.205000	3.87e-01
REGULATION OF HSF1 MEDIATED HEAT SHOCK RESPONSE	76	2.06e-03	-0.204000	1.03e-02
SIGNALING BY THE B CELL RECEPTOR BCR	103	3.38e-04	0.204000	2.17e-03
NEURONAL SYSTEM	371	1.50e-11	-0.204000	5.71e-10
ERK MAPK TARGETS	22	9.81e-02	-0.204000	2.03e-01
RAC2 GTPASE CYCLE	87	1.04e-03	-0.204000	5.59e-03
NGF STIMULATED TRANSCRIPTION	36	3.47e-02	-0.203000	9.40e-02
FATTY ACID METABOLISM	145	2.44e-05	0.203000	2.40e-04
CELLULAR RESPONSES TO EXTERNAL STIMULI	601	2.28e-17	0.203000	1.17e-15
NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	58	7.59e-03	-0.203000	2.94e-02
DISEASES OF PROGRAMMED CELL DEATH	54	1.00e-02	0.203000	3.66e-02
REGULATION OF SIGNALING BY CBL	22	1.00e-01	-0.202000	2.06e-01
MTOR SIGNALLING	40	2.67e-02	0.202000	7.75e-02
SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP	61	6.44e-03	0.202000	2.59e-02
SIGNALING BY FGFR3 FUSIONS IN CANCER	10	2.70e-01	-0.202000	4.16e-01
NS1 MEDIATED EFFECTS ON HOST PATHWAYS	37	3.46e-02	-0.201000	9.40e-02
SIGNALING BY VEGF	102	4.84e-04	-0.200000	2.93e-03
HDMS DEMETHYLATE HISTONES	28	6.71e-02	-0.200000	1.52e-01
ACETYLCHOLINE REGULATES INSULIN SECRETION	10	2.74e-01	-0.200000	4.19e-01
NR1H3 NR1H2 REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX	32	5.06e-02	-0.200000	1.24e-01
C TYPE LECTIN RECEPTORS CLRS	111	2.80e-04	0.200000	1.84e-03
PLATELET AGGREGATION PLUG FORMATION	31	5.48e-02	-0.199000	1.33e-01
RAS ACTIVATION UPON CA2 INFLUX THROUGH NMDA RECEPTOR	20	1.24e-01	-0.199000	2.41e-01
TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE	13	2.16e-01	0.198000	3.60e-01
FORMATION OF RNA POL II ELONGATION COMPLEX	57	9.98e-03	0.197000	3.66e-02
SYNTHESIS OF LEUKOTRIENES LT AND EOXINS EX	12	2.37e-01	0.197000	3.85e-01
MUCOPOLYSACCHARIDOSES	11	2.58e-01	-0.197000	4.07e-01
GRB2 EVENTS IN ERBB2 SIGNALING	15	1.87e-01	-0.197000	3.24e-01
ACTIVATION OF AMPK DOWNSTREAM OF NMDARS	20	1.28e-01	0.197000	2.46e-01
NETRIN 1 SIGNALING	50	1.64e-02	-0.196000	5.43e-02
PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	1.90e-01	0.195000	3.27e-01
SUMOYLATION OF DNA METHYLATION PROTEINS	16	1.77e-01	-0.195000	3.12e-01
DISEASES ASSOCIATED WITH N GLYCOSYLATION OF PROTEINS	17	1.65e-01	0.194000	2.98e-01
TELOMERE C STRAND LAGGING STRAND SYNTHESIS	33	5.63e-02	0.192000	1.35e-01
CYTOSOLIC IRON SULFUR CLUSTER ASSEMBLY	13	2.32e-01	0.191000	3.80e-01
COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES	63	8.62e-03	-0.191000	3.23e-02
INITIAL TRIGGERING OF COMPLEMENT	11	2.72e-01	0.191000	4.18e-01
PROLONGED ERK ACTIVATION EVENTS	13	2.34e-01	-0.191000	3.81e-01
NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION	181	9.80e-06	-0.191000	1.11e-04
ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS	22	1.22e-01	-0.191000	2.38e-01
CASPASE ACTIVATION VIA DEPENDENCE RECEPTORS IN THE ABSENCE OF LIGAND	10	2.98e-01	-0.190000	4.47e-01
CALNEXIN CALRETICULIN CYCLE	26	9.60e-02	-0.189000	2.01e-01
COMPLEMENT CASCADE	26	9.69e-02	0.188000	2.02e-01
PROGRAMMED CELL DEATH	185	1.06e-05	0.188000	1.18e-04
SYNTHESIS SECRETION AND INACTIVATION OF GLUCAGON LIKE PEPTIDE 1 GLP 1	12	2.61e-01	0.188000	4.08e-01
CS DS DEGRADATION	14	2.24e-01	-0.188000	3.70e-01
NON INTEGRIN MEMBRANE ECM INTERACTIONS	57	1.48e-02	-0.187000	5.01e-02
SHC1 EVENTS IN ERBB4 SIGNALING	13	2.44e-01	-0.186000	3.92e-01
COOPERATION OF PDCL PHLP1 AND TRIC CCT IN G PROTEIN BETA FOLDING	35	5.68e-02	0.186000	1.36e-01
RMTS METHYLATE HISTONE ARGININES	44	3.29e-02	0.186000	9.11e-02
SUMOYLATION OF INTRACELLULAR RECEPTORS	27	9.67e-02	-0.185000	2.02e-01
METALLOPROTEASE DUBS	26	1.03e-01	0.185000	2.10e-01
SIGNALING BY ERBB2 ECD MUTANTS	16	2.02e-01	-0.184000	3.42e-01
DNA DAMAGE BYPASS	48	2.77e-02	0.184000	7.97e-02
ARACHIDONIC ACID METABOLISM	39	4.74e-02	0.184000	1.18e-01
SIGNALING BY PDGFRA TRANSMEMBRANE JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS	12	2.71e-01	-0.183000	4.18e-01
CROSSLINKING OF COLLAGEN FIBRILS	16	2.05e-01	-0.183000	3.46e-01
SIGNALING BY EGFR	47	3.00e-02	-0.183000	8.55e-02
TRNA PROCESSING	105	1.20e-03	0.183000	6.37e-03
COLLAGEN CHAIN TRIMERIZATION	41	4.28e-02	-0.183000	1.11e-01
SIGNALING BY NOTCH3	48	2.86e-02	-0.183000	8.18e-02
PROLACTIN RECEPTOR SIGNALING	11	2.95e-01	-0.182000	4.42e-01
BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS SPMS	12	2.75e-01	0.182000	4.20e-01
AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	25	1.15e-01	-0.182000	2.27e-01
HYALURONAN METABOLISM	15	2.24e-01	-0.181000	3.70e-01
MITOTIC METAPHASE AND ANAPHASE	208	6.92e-06	0.181000	8.09e-05
CELLULAR RESPONSE TO HEAT STRESS	95	2.32e-03	-0.181000	1.15e-02
COLLAGEN DEGRADATION	52	2.41e-02	-0.181000	7.23e-02
PLASMA LIPOPROTEIN ASSEMBLY	12	2.80e-01	0.180000	4.27e-01
EPH EPHRIN MEDIATED REPULSION OF CELLS	50	2.76e-02	-0.180000	7.96e-02
RHO GTPASES ACTIVATE PKNS	47	3.31e-02	0.180000	9.12e-02
APOPTOTIC EXECUTION PHASE	45	3.78e-02	-0.179000	9.97e-02
NEDDYLATION	220	4.99e-06	0.179000	6.20e-05
GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	16	2.16e-01	-0.179000	3.61e-01
EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS	31	8.68e-02	-0.178000	1.87e-01
G ALPHA 12 13 SIGNALLING EVENTS	75	8.08e-03	-0.177000	3.08e-02
MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	15	2.35e-01	0.177000	3.83e-01
INTRINSIC PATHWAY FOR APOPTOSIS	52	2.79e-02	0.176000	8.01e-02
MAPK6 MAPK4 SIGNALING	83	5.60e-03	0.176000	2.38e-02
CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	73	9.38e-03	-0.176000	3.47e-02
RAC3 GTPASE CYCLE	89	4.26e-03	-0.175000	1.88e-02
DOWNSTREAM SIGNAL TRANSDUCTION	29	1.03e-01	-0.175000	2.09e-01
CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT	20	1.76e-01	0.175000	3.11e-01
DNA REPAIR	292	2.98e-07	0.175000	4.88e-06
CHEMOKINE RECEPTORS BIND CHEMOKINES	14	2.59e-01	-0.174000	4.08e-01
TRIGLYCERIDE METABOLISM	23	1.48e-01	0.174000	2.74e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONE GENES	10	3.41e-01	-0.174000	4.96e-01
PERK REGULATES GENE EXPRESSION	28	1.11e-01	0.174000	2.22e-01
ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS	84	6.16e-03	-0.173000	2.52e-02
RUNX1 INTERACTS WITH CO FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN	37	6.92e-02	-0.173000	1.56e-01
PLASMA LIPOPROTEIN REMODELING	14	2.64e-01	0.173000	4.12e-01
IRON UPTAKE AND TRANSPORT	52	3.19e-02	0.172000	8.92e-02
RAF INDEPENDENT MAPK1 3 ACTIVATION	21	1.74e-01	-0.171000	3.10e-01
APOPTOSIS	164	1.57e-04	0.171000	1.14e-03
TRANSMISSION ACROSS CHEMICAL SYNAPSES	243	4.82e-06	-0.171000	6.05e-05
ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	17	2.26e-01	-0.170000	3.72e-01
SIGNALING BY KIT IN DISEASE	20	1.90e-01	-0.169000	3.27e-01
SIGNALING BY FGFR2 IN DISEASE	38	7.10e-02	0.169000	1.58e-01
INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION	13	2.91e-01	0.169000	4.38e-01
CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER	65	1.89e-02	-0.168000	6.08e-02
OPIOID SIGNALLING	86	6.99e-03	-0.168000	2.76e-02
SIGNALING BY TGF BETA RECEPTOR COMPLEX	72	1.37e-02	-0.168000	4.73e-02
MITOTIC G2 G2 M PHASES	183	9.47e-05	0.167000	7.55e-04
HEPARAN SULFATE HEPARIN HS GAG METABOLISM	52	3.71e-02	-0.167000	9.86e-02
LDL CLEARANCE	16	2.48e-01	-0.167000	3.97e-01
EPHA MEDIATED GROWTH CONE COLLAPSE	28	1.27e-01	-0.167000	2.45e-01
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	23	1.68e-01	0.166000	3.01e-01
TRNA AMINOACYLATION	42	6.25e-02	0.166000	1.45e-01
MICRORNA MIRNA BIOGENESIS	24	1.62e-01	0.165000	2.93e-01
TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX	15	2.70e-01	0.165000	4.16e-01
FANCONI ANEMIA PATHWAY	37	8.31e-02	0.165000	1.81e-01
BUTYRATE RESPONSE FACTOR 1 BRF1 BINDS AND DESTABILIZES MRNA	16	2.54e-01	0.165000	4.04e-01
KINESINS	48	4.87e-02	-0.164000	1.20e-01
PI3K AKT SIGNALING IN CANCER	92	6.43e-03	-0.164000	2.59e-02
REGULATION OF GENE EXPRESSION BY HYPOXIA INDUCIBLE FACTOR	10	3.69e-01	-0.164000	5.27e-01
IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX	10	3.69e-01	0.164000	5.27e-01
PHASE 4 RESTING MEMBRANE POTENTIAL	14	2.89e-01	-0.164000	4.36e-01
REVERSIBLE HYDRATION OF CARBON DIOXIDE	10	3.70e-01	0.164000	5.28e-01
E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS	50	4.59e-02	0.163000	1.16e-01
CLASS A 1 RHODOPSIN LIKE RECEPTORS	185	1.34e-04	-0.163000	9.91e-04
TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	10	3.73e-01	0.163000	5.29e-01
INTERLEUKIN 17 SIGNALING	67	2.14e-02	-0.163000	6.61e-02
PARASITE INFECTION	55	3.71e-02	-0.163000	9.86e-02
ERCC6 CSB AND EHMT2 G9A POSITIVELY REGULATE RRNA EXPRESSION	32	1.13e-01	0.162000	2.24e-01
NEGATIVE REGULATION OF THE PI3K AKT NETWORK	98	5.61e-03	-0.162000	2.38e-02
COLLAGEN FORMATION	79	1.29e-02	-0.162000	4.48e-02
G PROTEIN BETA GAMMA SIGNALLING	30	1.25e-01	0.162000	2.43e-01
P75NTR RECRUITS SIGNALLING COMPLEXES	12	3.32e-01	0.162000	4.88e-01
DISEASES ASSOCIATED WITH O GLYCOSYLATION OF PROTEINS	51	4.59e-02	-0.162000	1.16e-01
EXTRA NUCLEAR ESTROGEN SIGNALING	67	2.25e-02	-0.161000	6.88e-02
SIGNALING BY GPCR	484	1.67e-09	-0.160000	3.87e-08
G ALPHA Z SIGNALLING EVENTS	44	6.58e-02	-0.160000	1.49e-01
TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS	54	4.18e-02	-0.160000	1.10e-01
CELL CYCLE CHECKPOINTS	243	1.76e-05	0.160000	1.79e-04
MRNA SPLICING	188	1.57e-04	0.160000	1.14e-03
HSF1 ACTIVATION	26	1.59e-01	-0.160000	2.88e-01
SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL	25	1.67e-01	-0.160000	3.01e-01
GLUCAGON TYPE LIGAND RECEPTORS	25	1.68e-01	0.159000	3.01e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR4	20	2.17e-01	-0.159000	3.61e-01
FORMATION OF THE BETA CATENIN TCF TRANSACTIVATING COMPLEX	46	6.16e-02	-0.159000	1.44e-01
O GLYCOSYLATION OF TSR DOMAIN CONTAINING PROTEINS	35	1.03e-01	-0.159000	2.10e-01
POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION	62	3.04e-02	0.159000	8.64e-02
SIGNALING BY NTRKS	129	1.91e-03	-0.158000	9.66e-03
ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY	10	3.87e-01	-0.158000	5.42e-01
EXTENSION OF TELOMERES	48	5.83e-02	0.158000	1.38e-01
INSULIN RECEPTOR SIGNALLING CASCADE	46	6.41e-02	-0.158000	1.47e-01
EFFECTS OF PIP2 HYDROLYSIS	27	1.58e-01	-0.157000	2.87e-01
INTEGRATION OF ENERGY METABOLISM	98	7.23e-03	-0.157000	2.83e-02
VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS	35	1.08e-01	-0.157000	2.17e-01
HEDGEHOG ON STATE	82	1.41e-02	0.157000	4.83e-02
MET PROMOTES CELL MOTILITY	39	9.16e-02	-0.156000	1.94e-01
SIGNALING BY FGFR1	45	7.02e-02	-0.156000	1.57e-01
NUCLEAR PORE COMPLEX NPC DISASSEMBLY	31	1.34e-01	-0.156000	2.54e-01
FCGAMMA RECEPTOR FCGR DEPENDENT PHAGOCYTOSIS	82	1.52e-02	-0.155000	5.13e-02
RAB GERANYLGERANYLATION	57	4.32e-02	0.155000	1.12e-01
ALPHA PROTEIN KINASE 1 SIGNALING PATHWAY	11	3.74e-01	0.155000	5.30e-01
SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	31	1.37e-01	-0.155000	2.58e-01
REGULATION OF INSULIN SECRETION	71	2.45e-02	-0.154000	7.32e-02
SYNTHESIS OF PA	29	1.51e-01	-0.154000	2.78e-01
PLATELET CALCIUM HOMEOSTASIS	25	1.83e-01	-0.154000	3.19e-01
ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	11	3.78e-01	0.153000	5.33e-01
MITOCHONDRIAL BIOGENESIS	92	1.16e-02	0.152000	4.14e-02
DISORDERS OF TRANSMEMBRANE TRANSPORTERS	144	1.64e-03	0.152000	8.40e-03
SYNTHESIS OF PC	26	1.81e-01	0.152000	3.17e-01
SIGNALING BY SCF KIT	41	9.45e-02	-0.151000	1.98e-01
SIGNALING BY NOTCH2	33	1.34e-01	-0.151000	2.54e-01
CYTOCHROME C MEDIATED APOPTOTIC RESPONSE	12	3.66e-01	0.151000	5.26e-01
TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53 DEPENDENT APOPTOSIS REMAIN UNCERTAIN	12	3.66e-01	0.151000	5.26e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR1	27	1.77e-01	-0.150000	3.12e-01
ION TRANSPORT BY P TYPE ATPASES	49	6.94e-02	-0.150000	1.56e-01
CLEC7A DECTIN 1 INDUCES NFAT ACTIVATION	11	3.89e-01	-0.150000	5.44e-01
TERMINATION OF O GLYCAN BIOSYNTHESIS	10	4.12e-01	0.150000	5.63e-01
CHK1 CHK2 CDS1 MEDIATED INACTIVATION OF CYCLIN B CDK1 COMPLEX	10	4.14e-01	0.149000	5.64e-01
SIGNALING BY TYPE 1 INSULIN LIKE GROWTH FACTOR 1 RECEPTOR IGF1R	46	8.17e-02	-0.148000	1.78e-01
PHASE I FUNCTIONALIZATION OF COMPOUNDS	60	4.74e-02	0.148000	1.18e-01
SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA	40	1.07e-01	-0.147000	2.16e-01
P75NTR SIGNALS VIA NF KB	15	3.24e-01	0.147000	4.78e-01
COPI MEDIATED ANTEROGRADE TRANSPORT	91	1.54e-02	0.147000	5.15e-02
REGULATION OF FZD BY UBIQUITINATION	19	2.68e-01	-0.147000	4.15e-01
IRS MEDIATED SIGNALLING	41	1.04e-01	-0.147000	2.10e-01
INTERLEUKIN 37 SIGNALING	18	2.82e-01	-0.147000	4.28e-01
HCMV LATE EVENTS	65	4.19e-02	0.146000	1.10e-01
OVARIAN TUMOR DOMAIN PROTEASES	36	1.31e-01	-0.146000	2.51e-01
G PROTEIN ACTIVATION	22	2.38e-01	0.145000	3.85e-01
TRANSCRIPTIONAL REGULATION BY RUNX3	93	1.55e-02	0.145000	5.16e-02
TRAF6 MEDIATED NF KB ACTIVATION	22	2.38e-01	-0.145000	3.86e-01
ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	28	1.86e-01	0.145000	3.23e-01
ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3	10	4.31e-01	-0.144000	5.80e-01
CTLA4 INHIBITORY SIGNALING	20	2.66e-01	-0.144000	4.14e-01
CAMK IV MEDIATED PHOSPHORYLATION OF CREB	10	4.34e-01	-0.143000	5.82e-01
FOXO MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS METABOLIC AND NEURONAL GENES	24	2.27e-01	-0.142000	3.73e-01
G ALPHA S SIGNALLING EVENTS	105	1.17e-02	-0.142000	4.15e-02
EXTRACELLULAR MATRIX ORGANIZATION	248	1.15e-04	-0.142000	8.79e-04
RAF ACTIVATION	34	1.52e-01	-0.142000	2.79e-01
METAL ION SLC TRANSPORTERS	25	2.20e-01	-0.142000	3.64e-01
FORMATION OF APOPTOSOME	10	4.39e-01	0.141000	5.88e-01
REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	29	1.88e-01	-0.141000	3.26e-01
ATF6 ATF6 ALPHA ACTIVATES CHAPERONES	12	3.97e-01	-0.141000	5.50e-01
SENSORY PROCESSING OF SOUND	60	5.88e-02	-0.141000	1.39e-01
TRANSCRIPTIONAL REGULATION BY SMALL RNAS	61	5.71e-02	0.141000	1.36e-01
MET ACTIVATES PTK2 SIGNALING	29	1.90e-01	-0.141000	3.27e-01
CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	12	3.99e-01	0.141000	5.52e-01
SUMOYLATION OF UBIQUITINYLATION PROTEINS	37	1.40e-01	-0.140000	2.63e-01
HIV LIFE CYCLE	142	4.15e-03	0.139000	1.84e-02
SCAVENGING BY CLASS A RECEPTORS	14	3.68e-01	0.139000	5.26e-01
RHOBTB1 GTPASE CYCLE	23	2.48e-01	-0.139000	3.97e-01
DERMATAN SULFATE BIOSYNTHESIS	11	4.26e-01	-0.139000	5.75e-01
LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS	20	2.84e-01	-0.138000	4.31e-01
ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES	52	8.61e-02	-0.138000	1.86e-01
KERATAN SULFATE DEGRADATION	11	4.30e-01	0.138000	5.79e-01
CARGO CONCENTRATION IN THE ER	29	2.00e-01	-0.137000	3.41e-01
IRE1ALPHA ACTIVATES CHAPERONES	50	9.33e-02	-0.137000	1.97e-01
SYNTHESIS OF ACTIVE UBIQUITIN ROLES OF E1 AND E2 ENZYMES	29	2.03e-01	0.137000	3.43e-01
EPHB MEDIATED FORWARD SIGNALING	42	1.26e-01	-0.136000	2.44e-01
TRAFFICKING OF AMPA RECEPTORS	31	1.89e-01	-0.136000	3.26e-01
CYTOSOLIC SULFONATION OF SMALL MOLECULES	15	3.62e-01	0.136000	5.24e-01
SUMOYLATION	166	2.55e-03	-0.136000	1.24e-02
SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS	41	1.33e-01	-0.136000	2.53e-01
RNA POLYMERASE II TRANSCRIPTION TERMINATION	65	5.86e-02	0.136000	1.39e-01
TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES	61	6.78e-02	0.135000	1.53e-01
PI 3K CASCADE FGFR3	14	3.83e-01	-0.135000	5.38e-01
PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	237	3.72e-04	0.134000	2.32e-03
INOSITOL PHOSPHATE METABOLISM	46	1.15e-01	-0.134000	2.27e-01
MISMATCH REPAIR	14	3.85e-01	0.134000	5.41e-01
REGULATION OF IFNG SIGNALING	13	4.04e-01	0.134000	5.56e-01
SIGNALING BY RHO GTPASES MIRO GTPASES AND RHOBTB3	631	1.10e-08	-0.134000	2.23e-07
ANTI INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION	116	1.29e-02	-0.134000	4.49e-02
DDX58 IFIH1 MEDIATED INDUCTION OF INTERFERON ALPHA BETA	64	6.45e-02	-0.134000	1.48e-01
NEGATIVE REGULATION OF FLT3	14	3.87e-01	0.134000	5.42e-01
METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES	20	3.02e-01	0.133000	4.52e-01
BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	76	4.50e-02	0.133000	1.14e-01
TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	13	4.06e-01	0.133000	5.60e-01
SNRNP ASSEMBLY	51	1.01e-01	0.133000	2.08e-01
PROCESSING OF CAPPED INTRONLESS PRE MRNA	28	2.25e-01	0.133000	3.70e-01
NEGATIVE REGULATORS OF DDX58 IFIH1 SIGNALING	34	1.81e-01	-0.133000	3.17e-01
RESOLUTION OF D LOOP STRUCTURES THROUGH SYNTHESIS DEPENDENT STRAND ANNEALING SDSA	24	2.62e-01	-0.132000	4.10e-01
RNA POLYMERASE I TRANSCRIPTION INITIATION	47	1.17e-01	0.132000	2.29e-01
INCRETIN SYNTHESIS SECRETION AND INACTIVATION	13	4.09e-01	0.132000	5.61e-01
PENTOSE PHOSPHATE PATHWAY	13	4.11e-01	0.132000	5.63e-01
ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	38	1.62e-01	0.131000	2.93e-01
NEUTROPHIL DEGRANULATION	387	9.96e-06	0.131000	1.12e-04
EPH EPHRIN SIGNALING	91	3.09e-02	-0.131000	8.74e-02
REGULATION OF KIT SIGNALING	16	3.64e-01	-0.131000	5.26e-01
SIGNALING BY ERBB4	57	8.74e-02	-0.131000	1.87e-01
ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	25	2.58e-01	-0.131000	4.07e-01
REGULATION OF IFNA SIGNALING	12	4.33e-01	-0.131000	5.81e-01
SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	14	3.97e-01	0.131000	5.50e-01
STRIATED MUSCLE CONTRACTION	25	2.60e-01	0.130000	4.08e-01
TRANSCRIPTIONAL REGULATION BY E2F6	34	1.89e-01	-0.130000	3.26e-01
INTERFERON GAMMA SIGNALING	79	4.57e-02	-0.130000	1.16e-01
METABOLISM OF VITAMINS AND COFACTORS	153	5.54e-03	0.130000	2.37e-02
TOLL LIKE RECEPTOR 9 TLR9 CASCADE	91	3.25e-02	-0.130000	9.05e-02
DEGRADATION OF THE EXTRACELLULAR MATRIX	110	1.91e-02	-0.129000	6.08e-02
CHOLESTEROL BIOSYNTHESIS	24	2.73e-01	-0.129000	4.19e-01
SURFACTANT METABOLISM	16	3.72e-01	-0.129000	5.29e-01
METABOLISM OF WATER SOLUBLE VITAMINS AND COFACTORS	103	2.46e-02	0.128000	7.32e-02
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE	19	3.35e-01	0.128000	4.92e-01
GPCR LIGAND BINDING	267	3.33e-04	-0.128000	2.15e-03
ACTIVATION OF THE PRE REPLICATIVE COMPLEX	31	2.20e-01	0.127000	3.64e-01
TNFR1 INDUCED PROAPOPTOTIC SIGNALING	12	4.46e-01	-0.127000	5.93e-01
AQUAPORIN MEDIATED TRANSPORT	38	1.77e-01	-0.127000	3.13e-01
CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER	26	2.64e-01	-0.127000	4.12e-01
ASPARTATE AND ASPARAGINE METABOLISM	11	4.68e-01	0.126000	6.14e-01
HYALURONAN UPTAKE AND DEGRADATION	11	4.70e-01	-0.126000	6.15e-01
DEATH RECEPTOR SIGNALLING	133	1.24e-02	-0.126000	4.34e-02
M PHASE	341	7.12e-05	0.125000	6.00e-04
LEISHMANIA INFECTION	195	2.64e-03	-0.125000	1.28e-02
SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	62	8.88e-02	0.125000	1.90e-01
PI 3K CASCADE FGFR2	18	3.59e-01	-0.125000	5.21e-01
INTEGRIN CELL SURFACE INTERACTIONS	73	6.57e-02	-0.125000	1.49e-01
CARDIAC CONDUCTION	107	2.63e-02	-0.124000	7.68e-02
SIGNALING BY NODAL	16	3.92e-01	-0.124000	5.47e-01
NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	15	4.08e-01	0.123000	5.60e-01
MET RECEPTOR RECYCLING	10	4.99e-01	-0.123000	6.41e-01
PYRIMIDINE SALVAGE	10	5.02e-01	0.123000	6.44e-01
INFECTIOUS DISEASE	730	2.31e-08	0.122000	4.54e-07
ERYTHROPOIETIN ACTIVATES RAS	13	4.47e-01	-0.122000	5.93e-01
FC EPSILON RECEPTOR FCERI SIGNALING	122	2.04e-02	0.122000	6.39e-02
FORMATION OF SENESCENCE ASSOCIATED HETEROCHROMATIN FOCI SAHF	15	4.16e-01	-0.121000	5.66e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12	19	3.63e-01	0.121000	5.24e-01
MEIOTIC SYNAPSIS	41	1.83e-01	0.120000	3.19e-01
GP1B IX V ACTIVATION SIGNALLING	10	5.12e-01	-0.120000	6.50e-01
P75 NTR RECEPTOR MEDIATED SIGNALLING	94	4.49e-02	-0.120000	1.14e-01
PROTEIN UBIQUITINATION	69	8.94e-02	0.118000	1.90e-01
SIGNALING BY RECEPTOR TYROSINE KINASES	464	1.41e-05	-0.118000	1.47e-04
TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	17	4.01e-01	-0.118000	5.53e-01
CHROMATIN MODIFYING ENZYMES	219	2.73e-03	-0.118000	1.30e-02
TRANSCRIPTIONAL REGULATION BY RUNX2	110	3.39e-02	0.117000	9.30e-02
INTERLEUKIN 10 SIGNALING	19	3.78e-01	-0.117000	5.33e-01
CLATHRIN MEDIATED ENDOCYTOSIS	132	2.07e-02	-0.117000	6.45e-02
POTASSIUM CHANNELS	90	5.62e-02	-0.117000	1.35e-01
N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	35	2.35e-01	-0.116000	3.83e-01
NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	17	4.07e-01	-0.116000	5.60e-01
PTK6 REGULATES RHO GTPASES RAS GTPASE AND MAP KINASES	13	4.69e-01	-0.116000	6.15e-01
O LINKED GLYCOSYLATION	86	6.33e-02	-0.116000	1.46e-01
SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS	58	1.27e-01	-0.116000	2.46e-01
CELL CYCLE MITOTIC	477	1.70e-05	0.115000	1.76e-04
NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	23	3.42e-01	-0.114000	4.98e-01
ADORA2B MEDIATED ANTI INFLAMMATORY CYTOKINES PRODUCTION	92	5.90e-02	-0.114000	1.39e-01
TELOMERE EXTENSION BY TELOMERASE	21	3.67e-01	0.114000	5.26e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	12	4.95e-01	0.114000	6.38e-01
SMOOTH MUSCLE CONTRACTION	32	2.66e-01	0.114000	4.14e-01
POSTMITOTIC NUCLEAR PORE COMPLEX NPC REFORMATION	26	3.21e-01	-0.112000	4.75e-01
ECM PROTEOGLYCANS	68	1.10e-01	-0.112000	2.21e-01
SUMOYLATION OF RNA BINDING PROTEINS	45	1.96e-01	-0.112000	3.35e-01
BBSOME MEDIATED CARGO TARGETING TO CILIUM	23	3.57e-01	0.111000	5.18e-01
REGULATION OF PTEN GENE TRANSCRIPTION	58	1.44e-01	-0.111000	2.69e-01
CELLULAR HEXOSE TRANSPORT	12	5.07e-01	0.111000	6.46e-01
CELL CYCLE	596	4.34e-06	0.111000	5.50e-05
NUCLEAR IMPORT OF REV PROTEIN	32	2.80e-01	-0.110000	4.27e-01
ORGANIC CATION ANION ZWITTERION TRANSPORT	11	5.27e-01	0.110000	6.60e-01
DEFECTS IN COBALAMIN B12 METABOLISM	13	4.92e-01	0.110000	6.35e-01
VIRAL MESSENGER RNA SYNTHESIS	42	2.17e-01	0.110000	3.61e-01
KERATINIZATION	31	2.90e-01	0.110000	4.36e-01
PLATELET HOMEOSTASIS	77	9.58e-02	-0.110000	2.01e-01
SUPPRESSION OF PHAGOSOMAL MATURATION	13	4.94e-01	0.110000	6.38e-01
RHO GTPASES ACTIVATE NADPH OXIDASES	20	3.96e-01	0.110000	5.50e-01
GLYCOGEN STORAGE DISEASES	12	5.12e-01	0.109000	6.50e-01
CELL EXTRACELLULAR MATRIX INTERACTIONS	18	4.23e-01	-0.109000	5.74e-01
DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS	370	3.28e-04	-0.109000	2.13e-03
MEIOSIS	67	1.23e-01	0.109000	2.40e-01
ZBP1 DAI MEDIATED INDUCTION OF TYPE I IFNS	18	4.24e-01	-0.109000	5.74e-01
G ALPHA I SIGNALLING EVENTS	200	8.23e-03	-0.109000	3.13e-02
DEADENYLATION DEPENDENT MRNA DECAY	55	1.65e-01	0.108000	2.98e-01
INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS	35	2.69e-01	-0.108000	4.16e-01
RAP1 SIGNALLING	15	4.70e-01	-0.108000	6.15e-01
HOMOLOGY DIRECTED REPAIR	106	5.65e-02	0.107000	1.35e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR3	21	3.95e-01	-0.107000	5.49e-01
GAP JUNCTION TRAFFICKING AND REGULATION	33	2.90e-01	0.106000	4.36e-01
HDR THROUGH HOMOLOGOUS RECOMBINATION HRR	63	1.45e-01	0.106000	2.70e-01
HS GAG DEGRADATION	20	4.13e-01	-0.106000	5.64e-01
DOWNSTREAM SIGNALING OF ACTIVATED FGFR2	25	3.66e-01	-0.104000	5.26e-01
NUCLEAR ENVELOPE NE REASSEMBLY	63	1.54e-01	0.104000	2.83e-01
RHOG GTPASE CYCLE	74	1.23e-01	-0.104000	2.40e-01
GLYCOSAMINOGLYCAN METABOLISM	114	5.64e-02	-0.104000	1.35e-01
SIGNALING BY MET	75	1.23e-01	-0.103000	2.40e-01
COSTIMULATION BY THE CD28 FAMILY	49	2.12e-01	-0.103000	3.56e-01
ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS	36	2.85e-01	-0.103000	4.32e-01
ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	34	3.00e-01	0.103000	4.49e-01
ONCOGENE INDUCED SENESCENCE	32	3.15e-01	-0.103000	4.68e-01
TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES	44	2.40e-01	-0.102000	3.87e-01
METABOLISM OF STEROIDS	116	5.68e-02	-0.102000	1.36e-01
AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	14	5.08e-01	0.102000	6.47e-01
INTRAFLAGELLAR TRANSPORT	51	2.08e-01	0.102000	3.51e-01
CD28 DEPENDENT VAV1 PATHWAY	11	5.59e-01	-0.102000	6.88e-01
CASPASE ACTIVATION VIA DEATH RECEPTORS IN THE PRESENCE OF LIGAND	13	5.25e-01	0.102000	6.60e-01
THE NLRP3 INFLAMMASOME	15	4.96e-01	-0.102000	6.38e-01
FORMATION OF THE CORNIFIED ENVELOPE	30	3.36e-01	0.101000	4.92e-01
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	20	4.32e-01	0.101000	5.81e-01
FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	120	5.61e-02	-0.101000	1.35e-01
SUMOYLATION OF SUMOYLATION PROTEINS	33	3.17e-01	-0.101000	4.71e-01
DNA DOUBLE STRAND BREAK REPAIR	135	4.38e-02	0.101000	1.13e-01
BETA CATENIN INDEPENDENT WNT SIGNALING	137	4.31e-02	0.100000	1.12e-01
DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE	44	2.51e-01	0.100000	4.00e-01
SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	18	4.63e-01	0.099900	6.10e-01
ESTROGEN DEPENDENT GENE EXPRESSION	104	7.85e-02	-0.099900	1.73e-01
CARGO RECOGNITION FOR CLATHRIN MEDIATED ENDOCYTOSIS	92	9.86e-02	-0.099700	2.04e-01
LYSINE CATABOLISM	11	5.67e-01	0.099600	6.93e-01
TRNA PROCESSING IN THE NUCLEUS	56	1.98e-01	0.099600	3.37e-01
PROCESSIVE SYNTHESIS ON THE C STRAND OF THE TELOMERE	19	4.55e-01	0.099000	6.03e-01
STIMULI SENSING CHANNELS	78	1.34e-01	-0.098300	2.54e-01
ER QUALITY CONTROL COMPARTMENT ERQC	21	4.36e-01	-0.098200	5.84e-01
MYD88 INDEPENDENT TLR4 CASCADE	93	1.02e-01	-0.098100	2.09e-01
SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS	73	1.47e-01	-0.098100	2.73e-01
RHOBTB3 ATPASE CYCLE	10	5.92e-01	-0.098000	7.12e-01
CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	48	2.40e-01	-0.098000	3.87e-01
PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	12	5.57e-01	0.098000	6.87e-01
HEDGEHOG OFF STATE	106	8.18e-02	0.097900	1.78e-01
TIE2 SIGNALING	17	4.86e-01	-0.097600	6.30e-01
SIGNALING BY ERBB2	48	2.44e-01	-0.097300	3.91e-01
SLC MEDIATED TRANSMEMBRANE TRANSPORT	190	2.11e-02	-0.097200	6.54e-02
INITIATION OF NUCLEAR ENVELOPE NE REFORMATION	16	5.03e-01	0.096800	6.44e-01
ADRENALINE NORADRENALINE INHIBITS INSULIN SECRETION	26	3.93e-01	-0.096700	5.48e-01
DEPOLYMERISATION OF THE NUCLEAR LAMINA	13	5.47e-01	-0.096600	6.77e-01
TRANSCRIPTIONAL REGULATION BY TP53	341	2.24e-03	0.096500	1.12e-02
DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	13	5.47e-01	0.096500	6.77e-01
MET ACTIVATES RAS SIGNALING	10	5.98e-01	-0.096400	7.17e-01
ESR MEDIATED SIGNALING	167	3.18e-02	-0.096400	8.91e-02
ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS	19	4.68e-01	0.096200	6.14e-01
DSCAM INTERACTIONS	11	5.82e-01	-0.096000	7.05e-01
SIGNALING BY PDGF	57	2.11e-01	-0.095900	3.54e-01
NUCLEAR ENVELOPE BREAKDOWN	48	2.51e-01	-0.095700	4.00e-01
ACYL CHAIN REMODELLING OF PG	10	6.01e-01	-0.095500	7.20e-01
SIGNALING BY CSF3 G CSF	29	3.73e-01	0.095500	5.30e-01
NEUROTRANSMITTER RELEASE CYCLE	48	2.53e-01	-0.095300	4.03e-01
INTERLEUKIN 20 FAMILY SIGNALING	15	5.23e-01	-0.095300	6.58e-01
PROCESSING OF DNA DOUBLE STRAND BREAK ENDS	69	1.72e-01	0.095000	3.08e-01
REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	15	5.25e-01	0.094700	6.60e-01
O LINKED GLYCOSYLATION OF MUCINS	42	2.90e-01	-0.094400	4.36e-01
RHO GTPASES ACTIVATE IQGAPS	24	4.24e-01	0.094200	5.74e-01
ERKS ARE INACTIVATED	13	5.57e-01	-0.094100	6.87e-01
TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	30	3.73e-01	0.094100	5.29e-01
IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	21	4.63e-01	0.092600	6.10e-01
EARLY PHASE OF HIV LIFE CYCLE	13	5.64e-01	0.092300	6.92e-01
DAP12 INTERACTIONS	31	3.76e-01	0.091800	5.31e-01
CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION	20	4.79e-01	-0.091500	6.24e-01
ER TO GOLGI ANTEROGRADE TRANSPORT	139	6.41e-02	0.091000	1.47e-01
LYSOSOME VESICLE BIOGENESIS	32	3.74e-01	0.090800	5.30e-01
DNA DOUBLE STRAND BREAK RESPONSE	52	2.58e-01	0.090600	4.08e-01
TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	74	1.80e-01	-0.090200	3.16e-01
ACYL CHAIN REMODELLING OF PC	16	5.32e-01	-0.090200	6.63e-01
CD28 CO STIMULATION	31	3.86e-01	-0.090100	5.41e-01
HCMV INFECTION	103	1.15e-01	0.089900	2.27e-01
CYTOSOLIC SENSORS OF PATHOGEN ASSOCIATED DNA	59	2.33e-01	0.089800	3.81e-01
PTEN REGULATION	133	7.40e-02	0.089800	1.64e-01
REPRODUCTION	78	1.71e-01	0.089800	3.05e-01
SENSORY PERCEPTION	148	6.11e-02	-0.089300	1.43e-01
SIGNALING BY PTK6	51	2.72e-01	-0.089000	4.18e-01
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	16	5.39e-01	0.088800	6.69e-01
COBALAMIN CBL VITAMIN B12 TRANSPORT AND METABOLISM	14	5.69e-01	0.087900	6.94e-01
EGFR DOWNREGULATION	28	4.24e-01	-0.087400	5.74e-01
PHOSPHOLIPASE C MEDIATED CASCADE FGFR2	13	5.86e-01	-0.087300	7.09e-01
INTERLEUKIN 4 AND INTERLEUKIN 13 SIGNALING	79	1.81e-01	-0.087000	3.17e-01
TICAM1 TRAF6 DEPENDENT INDUCTION OF TAK1 COMPLEX	11	6.17e-01	0.087000	7.34e-01
SIGNALING BY LEPTIN	10	6.35e-01	-0.086700	7.48e-01
FOXO MEDIATED TRANSCRIPTION OF CELL DEATH GENES	15	5.62e-01	0.086500	6.89e-01
INACTIVATION OF CSF3 G CSF SIGNALING	24	4.65e-01	0.086100	6.12e-01
SIGNALING BY FGFR4	34	3.88e-01	-0.085600	5.42e-01
JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	22	4.87e-01	-0.085500	6.31e-01
CD28 DEPENDENT PI3K AKT SIGNALING	21	4.98e-01	-0.085400	6.40e-01
IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	50	2.97e-01	0.085300	4.45e-01
KERATAN SULFATE BIOSYNTHESIS	24	4.71e-01	0.085100	6.15e-01
TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	30	4.23e-01	0.084600	5.74e-01
PI 3K CASCADE FGFR1	17	5.47e-01	-0.084400	6.77e-01
DEFECTS IN VITAMIN AND COFACTOR METABOLISM	21	5.04e-01	0.084300	6.44e-01
GAP JUNCTION DEGRADATION	11	6.30e-01	-0.084000	7.45e-01
PHOSPHOLIPID METABOLISM	186	4.89e-02	-0.083800	1.21e-01
COPI INDEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	44	3.37e-01	0.083700	4.92e-01
SIGNALLING TO RAS	19	5.28e-01	0.083700	6.60e-01
G ALPHA Q SIGNALLING EVENTS	157	7.15e-02	-0.083400	1.59e-01
GLUCAGON LIKE PEPTIDE 1 GLP1 REGULATES INSULIN SECRETION	38	3.75e-01	-0.083100	5.30e-01
MHC CLASS II ANTIGEN PRESENTATION	101	1.52e-01	0.082600	2.79e-01
POTENTIAL THERAPEUTICS FOR SARS	77	2.11e-01	-0.082500	3.54e-01
SIGNALING BY FGFR2	64	2.55e-01	0.082400	4.04e-01
INFLAMMASOMES	19	5.35e-01	-0.082100	6.66e-01
MATURATION OF SARS COV 2 SPIKE PROTEIN	29	4.46e-01	-0.081700	5.93e-01
ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	28	4.58e-01	0.081100	6.05e-01
PEPTIDE HORMONE METABOLISM	62	2.71e-01	-0.080800	4.18e-01
METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS	11	6.43e-01	0.080700	7.55e-01
TRP CHANNELS	21	5.22e-01	-0.080700	6.58e-01
TRANSCRIPTIONAL REGULATION BY THE AP 2 TFAP2 FAMILY OF TRANSCRIPTION FACTORS	33	4.24e-01	-0.080400	5.74e-01
SARS COV 1 INFECTION	48	3.39e-01	0.079900	4.94e-01
NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	12	6.34e-01	0.079500	7.48e-01
NICOTINATE METABOLISM	25	4.92e-01	0.079500	6.35e-01
RAB GEFS EXCHANGE GTP FOR GDP ON RABS	87	2.02e-01	-0.079200	3.42e-01
MITOCHONDRIAL TRNA AMINOACYLATION	21	5.31e-01	0.078900	6.62e-01
REGULATION OF LIPID METABOLISM BY PPARALPHA	108	1.58e-01	-0.078600	2.88e-01
ACTIVATION OF BH3 ONLY PROTEINS	30	4.58e-01	0.078300	6.05e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX	18	5.69e-01	0.077500	6.94e-01
SHC1 EVENTS IN EGFR SIGNALING	11	6.57e-01	-0.077400	7.65e-01
TICAM1 RIP1 MEDIATED IKK COMPLEX RECRUITMENT	18	5.70e-01	0.077300	6.94e-01
KERATAN SULFATE KERATIN METABOLISM	30	4.64e-01	0.077200	6.11e-01
DEADENYLATION OF MRNA	25	5.04e-01	-0.077200	6.44e-01
FOXO MEDIATED TRANSCRIPTION OF CELL CYCLE GENES	15	6.05e-01	-0.077200	7.22e-01
THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	29	4.73e-01	0.076900	6.18e-01
UB SPECIFIC PROCESSING PROTEASES	166	8.91e-02	0.076500	1.90e-01
SPRY REGULATION OF FGF SIGNALING	16	5.96e-01	0.076500	7.17e-01
TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA	34	4.41e-01	-0.076400	5.88e-01
GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	23	5.28e-01	-0.076100	6.60e-01
VISUAL PHOTOTRANSDUCTION	58	3.20e-01	-0.075500	4.74e-01
ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1	23	5.31e-01	0.075500	6.62e-01
RIPK1 MEDIATED REGULATED NECROSIS	25	5.18e-01	0.074700	6.56e-01
INTERFERON SIGNALING	167	9.66e-02	-0.074600	2.02e-01
TNF SIGNALING	43	3.98e-01	-0.074500	5.50e-01
PLASMA LIPOPROTEIN CLEARANCE	27	5.03e-01	-0.074400	6.44e-01
COPII MEDIATED VESICLE TRANSPORT	63	3.09e-01	0.074100	4.60e-01
FCERI MEDIATED CA 2 MOBILIZATION	25	5.23e-01	-0.073900	6.58e-01
SIGNALING BY FLT3 ITD AND TKD MUTANTS	16	6.10e-01	0.073700	7.27e-01
INTRACELLULAR SIGNALING BY SECOND MESSENGERS	285	3.29e-02	-0.073600	9.11e-02
ACYL CHAIN REMODELLING OF PS	14	6.38e-01	-0.072700	7.50e-01
SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS	11	6.78e-01	-0.072300	7.85e-01
RECYCLING PATHWAY OF L1	40	4.30e-01	-0.072200	5.79e-01
ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS	65	3.17e-01	0.071900	4.70e-01
INNATE IMMUNE SYSTEM	780	6.82e-04	0.071800	3.96e-03
A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	26	5.26e-01	-0.071800	6.60e-01
TRANSLOCATION OF SLC2A4 GLUT4 TO THE PLASMA MEMBRANE	63	3.26e-01	0.071600	4.80e-01
RNA POLYMERASE II TRANSCRIBES SNRNA GENES	74	2.87e-01	0.071600	4.35e-01
TRANSPORT OF BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	69	3.05e-01	-0.071400	4.55e-01
G2 M DNA DAMAGE CHECKPOINT	65	3.22e-01	0.071000	4.76e-01
HDACS DEACETYLATE HISTONES	46	4.08e-01	0.070500	5.60e-01
REGULATION OF GENE EXPRESSION IN BETA CELLS	12	6.73e-01	0.070300	7.80e-01
TOLL LIKE RECEPTOR TLR1 TLR2 CASCADE	93	2.42e-01	-0.070200	3.89e-01
DARPP 32 EVENTS	23	5.60e-01	-0.070200	6.88e-01
GLYCOGEN SYNTHESIS	14	6.50e-01	0.070100	7.58e-01
RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION	50	3.94e-01	-0.069800	5.48e-01
SHC MEDIATED CASCADE FGFR4	13	6.63e-01	-0.069700	7.71e-01
IRAK1 RECRUITS IKK COMPLEX	14	6.52e-01	-0.069700	7.60e-01
EPIGENETIC REGULATION OF GENE EXPRESSION	103	2.27e-01	0.068900	3.73e-01
PROCESSING OF INTRONLESS PRE MRNAS	19	6.04e-01	-0.068800	7.22e-01
CHONDROITIN SULFATE BIOSYNTHESIS	18	6.15e-01	-0.068500	7.32e-01
CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	348	2.93e-02	0.068100	8.37e-02
CARBOXYTERMINAL POST TRANSLATIONAL MODIFICATIONS OF TUBULIN	36	4.82e-01	0.067800	6.26e-01
SUMOYLATION OF DNA REPLICATION PROTEINS	43	4.46e-01	-0.067200	5.93e-01
TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS	41	4.58e-01	-0.067000	6.05e-01
ACYL CHAIN REMODELLING OF PE	16	6.44e-01	-0.066700	7.56e-01
SIGNALING BY EGFR IN CANCER	22	5.88e-01	-0.066700	7.11e-01
REGULATION OF INSULIN LIKE GROWTH FACTOR IGF TRANSPORT AND UPTAKE BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	91	2.73e-01	0.066500	4.19e-01
P38MAPK EVENTS	13	6.79e-01	0.066400	7.85e-01
DEFECTIVE B4GALT7 CAUSES EDS PROGEROID TYPE	20	6.09e-01	-0.066100	7.26e-01
NUCLEOBASE BIOSYNTHESIS	15	6.58e-01	0.066000	7.66e-01
G1 S SPECIFIC TRANSCRIPTION	26	5.66e-01	0.065100	6.92e-01
UPTAKE AND FUNCTION OF ANTHRAX TOXINS	11	7.09e-01	-0.065000	8.10e-01
ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	74	3.37e-01	-0.064600	4.92e-01
GLYCOGEN METABOLISM	25	5.79e-01	-0.064200	7.02e-01
GENE SILENCING BY RNA	84	3.11e-01	0.063900	4.63e-01
PEPTIDE LIGAND BINDING RECEPTORS	109	2.49e-01	-0.063900	3.98e-01
MAPK FAMILY SIGNALING CASCADES	290	6.18e-02	-0.063900	1.44e-01
CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE	49	4.41e-01	-0.063700	5.88e-01
SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL	10	7.27e-01	0.063600	8.23e-01
RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	104	2.65e-01	0.063300	4.13e-01
ION CHANNEL TRANSPORT	144	1.95e-01	-0.062600	3.34e-01
MAP3K8 TPL2 DEPENDENT MAPK1 3 ACTIVATION	16	6.68e-01	-0.061900	7.75e-01
FLT3 SIGNALING	36	5.22e-01	-0.061600	6.58e-01
SIGNALING BY FGFR3	36	5.23e-01	-0.061600	6.58e-01
TOLL LIKE RECEPTOR CASCADES	138	2.15e-01	-0.061200	3.60e-01
ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	288	7.46e-02	0.061200	1.65e-01
FRS MEDIATED FGFR4 SIGNALING	15	6.83e-01	-0.060900	7.87e-01
SYNDECAN INTERACTIONS	26	5.91e-01	-0.060900	7.12e-01
CYCLIN D ASSOCIATED EVENTS IN G1	45	4.80e-01	0.060800	6.25e-01
CGMP EFFECTS	15	6.85e-01	-0.060500	7.89e-01
NUCLEAR SIGNALING BY ERBB4	31	5.67e-01	-0.059500	6.93e-01
MITOTIC PROPHASE	93	3.26e-01	0.058900	4.80e-01
RAB REGULATION OF TRAFFICKING	117	2.75e-01	-0.058400	4.20e-01
FGFR2 LIGAND BINDING AND ACTIVATION	13	7.16e-01	-0.058300	8.16e-01
ZINC TRANSPORTERS	16	6.90e-01	-0.057600	7.92e-01
RHO GTPASES ACTIVATE PAKS	21	6.48e-01	-0.057500	7.58e-01
TRANSLATION OF SARS COV 2 STRUCTURAL PROTEINS	44	5.10e-01	-0.057400	6.50e-01
BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS	35	5.62e-01	0.056700	6.89e-01
REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION	86	3.67e-01	0.056300	5.26e-01
PRE NOTCH EXPRESSION AND PROCESSING	63	4.40e-01	-0.056200	5.88e-01
MITOTIC SPINDLE CHECKPOINT	99	3.36e-01	0.056000	4.92e-01
ACTIVATION OF THE TFAP2 AP 2 FAMILY OF TRANSCRIPTION FACTORS	10	7.61e-01	0.055700	8.50e-01
NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	26	6.25e-01	-0.055400	7.41e-01
PRE NOTCH PROCESSING IN GOLGI	17	6.94e-01	-0.055100	7.95e-01
SUMOYLATION OF IMMUNE RESPONSE PROTEINS	11	7.52e-01	0.055100	8.42e-01
NEGATIVE REGULATION OF MET ACTIVITY	21	6.67e-01	-0.054300	7.74e-01
HEMOSTASIS	474	4.46e-02	-0.054000	1.14e-01
MAP2K AND MAPK ACTIVATION	36	5.75e-01	-0.054000	6.99e-01
INFECTION WITH MYCOBACTERIUM TUBERCULOSIS	25	6.43e-01	0.053600	7.55e-01
TNF RECEPTOR SUPERFAMILY TNFSF MEMBERS MEDIATING NON CANONICAL NF KB PATHWAY	12	7.48e-01	0.053500	8.42e-01
E2F MEDIATED REGULATION OF DNA REPLICATION	20	6.83e-01	-0.052700	7.87e-01
ION HOMEOSTASIS	49	5.30e-01	-0.051900	6.62e-01
GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	18	7.05e-01	-0.051500	8.06e-01
RESOLUTION OF D LOOP STRUCTURES	30	6.27e-01	-0.051200	7.42e-01
TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS	44	5.60e-01	0.050900	6.88e-01
DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM	39	5.84e-01	0.050700	7.08e-01
APOPTOSIS INDUCED DNA FRAGMENTATION	11	7.75e-01	0.049700	8.59e-01
SIGNALING BY INTERLEUKINS	350	1.12e-01	0.049600	2.23e-01
METABOLISM OF NITRIC OXIDE NOS3 ACTIVATION AND REGULATION	15	7.40e-01	0.049400	8.35e-01
CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	31	6.35e-01	0.049300	7.48e-01
MUSCLE CONTRACTION	158	2.86e-01	-0.049200	4.34e-01
MEMBRANE TRAFFICKING	575	4.74e-02	-0.048600	1.18e-01
VITAMIN B5 PANTOTHENATE METABOLISM	15	7.45e-01	-0.048600	8.39e-01
CONSTITUTIVE SIGNALING BY LIGAND RESPONSIVE EGFR CANCER VARIANTS	19	7.19e-01	-0.047700	8.17e-01
INTRA GOLGI TRAFFIC	43	5.90e-01	-0.047600	7.11e-01
RHO GTPASES ACTIVATE ROCKS	19	7.24e-01	0.046800	8.20e-01
IL 6 TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS	14	7.66e-01	0.045900	8.54e-01
TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES	11	7.93e-01	-0.045800	8.76e-01
SIGNALING BY NUCLEAR RECEPTORS	222	2.41e-01	-0.045800	3.87e-01
ELASTIC FIBRE FORMATION	39	6.21e-01	-0.045700	7.38e-01
INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	34	6.45e-01	-0.045700	7.56e-01
BILE ACID AND BILE SALT METABOLISM	25	6.93e-01	-0.045600	7.95e-01
VESICLE MEDIATED TRANSPORT	608	5.71e-02	-0.045400	1.36e-01
ASPARAGINE N LINKED GLYCOSYLATION	282	1.92e-01	0.045300	3.29e-01
ROLE OF SECOND MESSENGERS IN NETRIN 1 SIGNALING	10	8.07e-01	-0.044600	8.89e-01
HDR THROUGH SINGLE STRAND ANNEALING SSA	36	6.49e-01	0.043800	7.58e-01
SLC TRANSPORTER DISORDERS	75	5.13e-01	-0.043700	6.51e-01
DEFECTIVE EXT2 CAUSES EXOSTOSES 2	14	7.78e-01	-0.043600	8.61e-01
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	7.69e-01	0.042500	8.56e-01
GOLGI ASSOCIATED VESICLE BIOGENESIS	54	5.93e-01	-0.042000	7.14e-01
OLFACTORY SIGNALING PATHWAY	32	6.83e-01	-0.041700	7.87e-01
ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE	96	4.81e-01	-0.041700	6.25e-01
GLUCOSE METABOLISM	80	5.21e-01	0.041600	6.58e-01
DISEASES OF IMMUNE SYSTEM	25	7.21e-01	0.041300	8.18e-01
DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	26	7.17e-01	-0.041000	8.17e-01
TICAM1 DEPENDENT ACTIVATION OF IRF3 IRF7	12	8.09e-01	0.040400	8.89e-01
THE PHOTOTRANSDUCTION CASCADE	19	7.65e-01	-0.039600	8.54e-01
POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	63	5.87e-01	-0.039500	7.10e-01
NOD1 2 SIGNALING PATHWAY	35	6.88e-01	0.039200	7.92e-01
AURKA ACTIVATION BY TPX2	71	5.70e-01	0.039000	6.94e-01
REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION	84	5.39e-01	0.038800	6.69e-01
REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA	13	8.11e-01	-0.038300	8.90e-01
SIGNALING BY NOTCH	188	3.73e-01	0.037700	5.29e-01
G0 AND EARLY G1	24	7.50e-01	0.037500	8.42e-01
ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	10	8.39e-01	-0.037100	9.11e-01
HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	10	8.39e-01	-0.037100	9.11e-01
DISEASES OF CARBOHYDRATE METABOLISM	29	7.35e-01	0.036400	8.29e-01
LGI ADAM INTERACTIONS	14	8.17e-01	-0.035800	8.93e-01
ADAPTIVE IMMUNE SYSTEM	607	1.36e-01	0.035600	2.57e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST	12	8.34e-01	0.034900	9.09e-01
DISEASES OF MITOTIC CELL CYCLE	37	7.21e-01	0.033900	8.18e-01
TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	79	6.03e-01	0.033900	7.22e-01
DISEASES OF METABOLISM	198	4.15e-01	0.033700	5.65e-01
UNFOLDED PROTEIN RESPONSE UPR	86	5.98e-01	-0.032900	7.17e-01
NEGATIVE REGULATION OF FGFR1 SIGNALING	28	7.67e-01	0.032400	8.54e-01
RHOH GTPASE CYCLE	37	7.34e-01	-0.032300	8.29e-01
RHO GTPASES ACTIVATE WASPS AND WAVES	36	7.42e-01	-0.031700	8.37e-01
ORGANELLE BIOGENESIS AND MAINTENANCE	283	3.63e-01	0.031500	5.24e-01
TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	32	7.71e-01	-0.029700	8.57e-01
SARS COV INFECTIONS	140	5.48e-01	-0.029500	6.77e-01
RIP MEDIATED NFKB ACTIVATION VIA ZBP1	15	8.44e-01	-0.029400	9.13e-01
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	23	8.10e-01	0.029000	8.89e-01
SHC MEDIATED CASCADE FGFR1	17	8.40e-01	0.028300	9.11e-01
FLT3 SIGNALING IN DISEASE	28	8.00e-01	-0.027700	8.82e-01
CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	92	6.47e-01	-0.027600	7.58e-01
CILIUM ASSEMBLY	191	5.15e-01	-0.027400	6.53e-01
NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS	12	8.70e-01	0.027300	9.29e-01
FERTILIZATION	11	8.76e-01	-0.027100	9.32e-01
THE ROLE OF NEF IN HIV 1 REPLICATION AND DISEASE PATHOGENESIS	26	8.12e-01	0.027000	8.90e-01
METABOLISM OF LIPIDS	616	2.59e-01	0.026700	4.08e-01
DEUBIQUITINATION	240	4.84e-01	0.026300	6.28e-01
ALPHA LINOLENIC OMEGA3 AND LINOLEIC OMEGA6 ACID METABOLISM	12	8.76e-01	0.025900	9.32e-01
TBC RABGAPS	42	7.76e-01	-0.025400	8.59e-01
CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY	23	8.35e-01	-0.025100	9.09e-01
FRS MEDIATED FGFR1 SIGNALING	19	8.51e-01	0.024900	9.18e-01
FOXO MEDIATED TRANSCRIPTION	57	7.51e-01	0.024300	8.42e-01
SIGNALING BY WNT	266	4.96e-01	-0.024300	6.38e-01
ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS	17	8.63e-01	-0.024100	9.28e-01
RETROGRADE TRANSPORT AT THE TRANS GOLGI NETWORK	48	7.76e-01	0.023800	8.59e-01
RNA POLYMERASE II TRANSCRIPTION	1093	1.89e-01	-0.023700	3.26e-01
REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION	30	8.24e-01	-0.023500	9.00e-01
REGULATION OF TP53 ACTIVITY THROUGH METHYLATION	18	8.65e-01	0.023200	9.28e-01
TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST	15	8.77e-01	0.023000	9.32e-01
GLYCOLYSIS	66	7.49e-01	-0.022800	8.42e-01
RESOLUTION OF SISTER CHROMATID COHESION	103	6.90e-01	0.022800	7.92e-01
REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS	12	8.92e-01	-0.022700	9.42e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD2 FZD5 AND ROR2	13	8.88e-01	-0.022500	9.41e-01
DOWNREGULATION OF ERBB2 SIGNALING	28	8.39e-01	-0.022200	9.11e-01
GLYCOSPHINGOLIPID METABOLISM	38	8.13e-01	0.022200	8.90e-01
REGULATION OF TP53 EXPRESSION AND DEGRADATION	33	8.27e-01	0.022000	9.03e-01
TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	168	6.25e-01	0.021900	7.41e-01
SARS COV 2 INFECTION	65	7.61e-01	0.021900	8.50e-01
TCF DEPENDENT SIGNALING IN RESPONSE TO WNT	177	6.20e-01	-0.021700	7.36e-01
ENDOGENOUS STEROLS	20	8.67e-01	0.021600	9.28e-01
SPHINGOLIPID DE NOVO BIOSYNTHESIS	42	8.09e-01	-0.021500	8.89e-01
DISEASES OF GLYCOSYLATION	124	6.82e-01	0.021300	7.87e-01
INLB MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL	15	8.87e-01	-0.021200	9.41e-01
POST TRANSLATIONAL PROTEIN MODIFICATION	1226	2.16e-01	0.021200	3.60e-01
GPVI MEDIATED ACTIVATION CASCADE	31	8.41e-01	-0.020800	9.11e-01
TRANSCRIPTIONAL REGULATION BY RUNX1	179	6.37e-01	0.020500	7.50e-01
NICOTINAMIDE SALVAGING	15	8.91e-01	0.020400	9.42e-01
RETROGRADE NEUROTROPHIN SIGNALLING	13	8.99e-01	-0.020300	9.44e-01
NEGATIVE REGULATION OF FGFR4 SIGNALING	24	8.65e-01	-0.020100	9.28e-01
SEMA4D IN SEMAPHORIN SIGNALING	24	8.66e-01	-0.019900	9.28e-01
DEVELOPMENTAL BIOLOGY	821	3.47e-01	-0.019400	5.04e-01
DAP12 SIGNALING	24	8.69e-01	0.019400	9.29e-01
SIALIC ACID METABOLISM	32	8.50e-01	-0.019400	9.18e-01
ELEVATION OF CYTOSOLIC CA2 LEVELS	14	9.01e-01	-0.019300	9.45e-01
RHO GTPASES ACTIVATE FORMINS	121	7.19e-01	0.019000	8.17e-01
UPTAKE AND ACTIONS OF BACTERIAL TOXINS	28	8.63e-01	-0.018900	9.28e-01
SIGNALING BY HEDGEHOG	141	7.01e-01	-0.018700	8.03e-01
DISEASES OF DNA REPAIR	11	9.16e-01	0.018500	9.52e-01
NEGATIVE REGULATION OF FGFR3 SIGNALING	25	8.75e-01	0.018200	9.32e-01
OTHER INTERLEUKIN SIGNALING	20	8.89e-01	0.018100	9.41e-01
CLASS B 2 SECRETIN FAMILY RECEPTORS	71	7.95e-01	0.017800	8.77e-01
THE CANONICAL RETINOID CYCLE IN RODS TWILIGHT VISION	14	9.08e-01	0.017800	9.49e-01
REGULATION OF TNFR1 SIGNALING	34	8.58e-01	-0.017800	9.23e-01
TRANSLATION OF SARS COV 1 STRUCTURAL PROTEINS	28	8.74e-01	-0.017400	9.32e-01
WNT5A DEPENDENT INTERNALIZATION OF FZD4	15	9.08e-01	-0.017300	9.49e-01
RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	85	7.87e-01	0.017000	8.70e-01
FRS MEDIATED FGFR2 SIGNALING	20	8.96e-01	-0.016900	9.43e-01
INTERLEUKIN 6 FAMILY SIGNALING	20	8.97e-01	0.016700	9.43e-01
SUMOYLATION OF TRANSCRIPTION FACTORS	18	9.03e-01	-0.016600	9.45e-01
PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION	22	8.95e-01	-0.016300	9.43e-01
REGULATED PROTEOLYSIS OF P75NTR	12	9.23e-01	-0.016100	9.58e-01
TNFR1 INDUCED NFKAPPAB SIGNALING PATHWAY	29	8.90e-01	-0.014800	9.42e-01
COPI DEPENDENT GOLGI TO ER RETROGRADE TRAFFIC	87	8.12e-01	-0.014800	8.90e-01
REGULATION OF TP53 ACTIVITY	150	7.56e-01	-0.014700	8.46e-01
PLATELET ACTIVATION SIGNALING AND AGGREGATION	221	7.14e-01	-0.014300	8.15e-01
SYNTHESIS OF BILE ACIDS AND BILE SALTS	22	9.08e-01	-0.014200	9.49e-01
RHO GTPASES ACTIVATE CIT	18	9.18e-01	0.014000	9.54e-01
WNT LIGAND BIOGENESIS AND TRAFFICKING	21	9.12e-01	-0.013900	9.51e-01
FATTY ACYL COA BIOSYNTHESIS	32	8.94e-01	0.013600	9.43e-01
BASIGIN INTERACTIONS	22	9.14e-01	-0.013300	9.51e-01
NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	53	8.67e-01	-0.013300	9.28e-01
BIOTIN TRANSPORT AND METABOLISM	11	9.40e-01	-0.013200	9.69e-01
MOLECULES ASSOCIATED WITH ELASTIC FIBRES	34	8.94e-01	-0.013200	9.43e-01
VLDLR INTERNALISATION AND DEGRADATION	12	9.37e-01	0.013200	9.69e-01
SIGNALING BY INSULIN RECEPTOR	65	8.55e-01	-0.013100	9.21e-01
RHO GTPASE EFFECTORS	252	7.26e-01	0.012800	8.23e-01
RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	78	8.50e-01	0.012400	9.18e-01
HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE	40	8.98e-01	0.011800	9.43e-01
BLOOD GROUP SYSTEMS BIOSYNTHESIS	14	9.40e-01	0.011700	9.69e-01
SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	20	9.29e-01	-0.011500	9.63e-01
GOLGI TO ER RETROGRADE TRANSPORT	120	8.34e-01	-0.011100	9.09e-01
TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 RBL1 AND P130 RBL2 IN COMPLEX WITH HDAC1	15	9.44e-01	-0.010500	9.72e-01
HDR THROUGH MMEJ ALT NHEJ	10	9.55e-01	-0.010300	9.82e-01
CELLULAR SENESCENCE	141	8.41e-01	-0.009790	9.11e-01
NONHOMOLOGOUS END JOINING NHEJ	43	9.14e-01	0.009510	9.51e-01
CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2	11	9.58e-01	-0.009110	9.83e-01
FGFR1 LIGAND BINDING AND ACTIVATION	11	9.59e-01	0.009040	9.83e-01
GLYCEROPHOSPHOLIPID BIOSYNTHESIS	107	8.76e-01	0.008730	9.32e-01
SYNTHESIS OF PE	13	9.58e-01	0.008350	9.83e-01
TRANS GOLGI NETWORK VESICLE BUDDING	69	9.11e-01	-0.007740	9.51e-01
SIGNALLING TO ERKS	33	9.39e-01	-0.007650	9.69e-01
HSP90 CHAPERONE CYCLE FOR STEROID HORMONE RECEPTORS SHR	48	9.27e-01	0.007630	9.61e-01
NERVOUS SYSTEM DEVELOPMENT	549	7.72e-01	0.007250	8.58e-01
DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER S DISEASE MODELS	19	9.62e-01	-0.006340	9.83e-01
INTERFERON ALPHA BETA SIGNALING	56	9.39e-01	0.005920	9.69e-01
INTRA GOLGI AND RETROGRADE GOLGI TO ER TRAFFIC	186	9.03e-01	-0.005190	9.45e-01
PLATELET ADHESION TO EXPOSED COLLAGEN	11	9.78e-01	-0.004750	9.93e-01
METABOLISM OF FAT SOLUBLE VITAMINS	32	9.66e-01	-0.004400	9.86e-01
NEUROTOXICITY OF CLOSTRIDIUM TOXINS	10	9.81e-01	0.004360	9.93e-01
RESPONSE OF MTB TO PHAGOCYTOSIS	22	9.73e-01	0.004240	9.92e-01
REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION	10	9.82e-01	0.004110	9.93e-01
CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	10	9.83e-01	0.004000	9.93e-01
INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	9.81e-01	0.003760	9.93e-01
CARNITINE METABOLISM	14	9.83e-01	-0.003370	9.93e-01
HCMV EARLY EVENTS	80	9.59e-01	0.003310	9.83e-01
NEGATIVE REGULATION OF FGFR2 SIGNALING	29	9.76e-01	0.003280	9.93e-01
SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	20	9.82e-01	0.002930	9.93e-01
HATS ACETYLATE HISTONES	93	9.63e-01	-0.002770	9.84e-01
GENERATION OF SECOND MESSENGER MOLECULES	18	9.87e-01	0.002220	9.94e-01
TIGHT JUNCTION INTERACTIONS	15	9.88e-01	0.002170	9.94e-01
POLO LIKE KINASE MEDIATED EVENTS	13	9.89e-01	0.002160	9.94e-01
METABOLISM OF CARBOHYDRATES	259	9.52e-01	-0.002160	9.80e-01
SHC MEDIATED CASCADE FGFR3	14	9.89e-01	0.002050	9.94e-01
PLASMA LIPOPROTEIN ASSEMBLY REMODELING AND CLEARANCE	49	9.81e-01	-0.001980	9.93e-01
INWARDLY RECTIFYING K CHANNELS	31	9.85e-01	-0.001920	9.94e-01
TRANSPORT OF SMALL MOLECULES	582	9.42e-01	-0.001770	9.71e-01
NEGATIVE REGULATION OF MAPK PATHWAY	42	9.86e-01	0.001580	9.94e-01
OXIDATIVE STRESS INDUCED SENESCENCE	78	9.83e-01	-0.001400	9.93e-01
SIGNAL AMPLIFICATION	30	9.90e-01	0.001380	9.94e-01
FRS MEDIATED FGFR3 SIGNALING	16	9.93e-01	0.001340	9.95e-01
MITOTIC PROMETAPHASE	178	9.76e-01	0.001290	9.93e-01
CYTOKINE SIGNALING IN IMMUNE SYSTEM	547	9.61e-01	0.001220	9.83e-01
ENOS ACTIVATION	11	9.96e-01	-0.000865	9.97e-01
SPHINGOLIPID METABOLISM	80	9.91e-01	-0.000769	9.94e-01
SIGNALING BY FGFR IN DISEASE	57	9.95e-01	-0.000498	9.97e-01
SIGNALING BY FGFR	75	9.97e-01	-0.000237	9.97e-01

---

Detailed Gene set reports

EUKARYOTIC TRANSLATION ELONGATION

EUKARYOTIC TRANSLATION ELONGATION

	305
set	EUKARYOTIC TRANSLATION ELONGATION
setSize	87
pANOVA	4.06e-44
s.dist	0.862
p.adjustANOVA	1.6e-41

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Rpl30	7145
Rpl8	7137
Rps13	7086
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Eef1d	6818
Eef1b2	6809
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpl27a	6473
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Eef1g	6077
Rps4x	5999
Eef1a1	5792
Rpsa	5712
Rpl6	5583
Rpl10	2228
Eef2	1448
Eef1a2	159

---

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY

	840
set	RESPONSE OF EIF2AK4 GCN2 TO AMINO ACID DEFICIENCY
setSize	95
pANOVA	1.55e-37
s.dist	0.759
p.adjustANOVA	1.83e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Atf4	7703
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Rpl30	7145
Rpl8	7137
Rps13	7086
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpl27a	6473
Eif2s1	6435
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Rps4x	5999
Rpsa	5712
Ddit3	5632
Rpl6	5583
Eif2s2	4515
Rpl10	2228
Cebpb	1745
Trib3	491
Atf3	449
Cebpg	-545
Eif2s3x	-729
Asns	-1790
Eif2ak4	-5310
Impact	-5768
Gcn1	-7117
Atf2	-7475

---

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE

	1013
set	SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE
setSize	106
pANOVA	1.13e-41
s.dist	0.759
p.adjustANOVA	2.66e-39

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Sec61b	8019
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Sec61b	8019
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Sec11c	7713
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Srp9	7428
Rpl9	7416
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Rpl30	7145
Rpl8	7137
Rps13	7086
Srp14	7072
Sec61g	7020
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Sec11a	6840
Spcs1	6830
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpl27a	6473
Ssr4	6450
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Rps4x	5999
Ssr2	5935
Srp19	5834
Rpsa	5712
Rpl6	5583
Srprb	5181
Spcs2	4468
Ddost	2939
Ssr3	2761
Rpl10	2228
Srp54a	1716
Sec61a2	1290
Rpn1	1064
Sec61a1	997
Spcs3	5
Srp68	-1233
Rpn2	-1692
Ssr1	-2771
Srpr	-5713
Srp72	-6413
Tram1	-6559

---

MITOCHONDRIAL TRANSLATION

MITOCHONDRIAL TRANSLATION

	572
set	MITOCHONDRIAL TRANSLATION
setSize	93
pANOVA	3e-36
s.dist	0.753
p.adjustANOVA	2.95e-34

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Mrpl58	8214
Mrps28	8103
Mrps21	8096
Mrpl52	8073
Mrpl2	7995
Mrpl54	7979
Mrpl53	7963
Mrpl20	7935
Gadd45gip1	7925
Mrps26	7914
Mrps34	7892
Mrpl41	7862
Mrps18c	7852
Mrps33	7840
Mrps16	7811
Mrpl30	7759
Mrpl51	7714
Mrps12	7682
Mrps24	7658
Mrpl9	7634

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Mrpl58	8214
Mrps28	8103
Mrps21	8096
Mrpl52	8073
Mrpl2	7995
Mrpl54	7979
Mrpl53	7963
Mrpl20	7935
Gadd45gip1	7925
Mrps26	7914
Mrps34	7892
Mrpl41	7862
Mrps18c	7852
Mrps33	7840
Mrps16	7811
Mrpl30	7759
Mrpl51	7714
Mrps12	7682
Mrps24	7658
Mrpl9	7634
Mrpl44	7629
Mrpl48	7613
Aurkaip1	7607
Mrpl40	7597
Mrpl43	7584
Mrpl11	7504
Mrpl27	7435
Mrpl28	7434
Mrps27	7433
Mrpl21	7329
Mrpl14	7319
Mrpl1	7306
Mrpl12	7266
Mrpl39	7228
Mrps23	7220
Mrpl13	7209
Mrpl33	7159
Mrpl49	7147
Mrps36	7138
Mrpl34	7119
Mrps10	6998
Mrpl23	6996
Mrpl55	6981
Mrps14	6937
Mrps7	6882
Mrpl46	6880
Mrps9	6863
Mrpl42	6852
Mrps15	6821
Mrpl15	6817
Mrps17	6815
Mrpl35	6775
Tsfm	6732
Mrpl57	6671
Mrpl17	6518
Mrpl18	6485
Mrpl16	6368
Mtfmt	6338
Mrps18b	6221
Mrpl36	6087
Mrps22	6072
Mrpl32	5936
Mrps35	5721
Mrps18a	5714
Mrps6	5692
Mrpl22	5672
Mrrf	5635
Mrpl38	5614
Mtif3	5553
Eral1	5486
Mrpl50	5286
Mrpl10	5121
Chchd1	5107
Mrps25	5084
Mrpl3	5004
Mrps11	4972
Mrpl47	4959
Mtif2	4929
Mrpl19	4784
Mrpl4	4557
Tufm	4339
Mrpl24	3938
Mrpl37	3706
Dap3	3603
Mrps2	3578
Mrps30	3131
Oxa1l	2368
Gfm1	1820
Mrps31	1637
Mrps5	1615
Ptcd3	1490
Mtrf1l	-4850
Gfm2	-7057

---

EUKARYOTIC TRANSLATION INITIATION

EUKARYOTIC TRANSLATION INITIATION

	306
set	EUKARYOTIC TRANSLATION INITIATION
setSize	114
pANOVA	1.77e-43
s.dist	0.748
p.adjustANOVA	5.22e-41

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Eif3g	7476
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Eif3i	7245
Eif3m	7176
Rpl30	7145
Rpl8	7137
Rps13	7086
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Rpl13a	6776
Rpl4	6774
Rps3	6754
Eif3h	6729
Rps27l	6682
Eif2b1	6658
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Eif3j1	6602
Rpl27a	6473
Eif2s1	6435
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Eif2b2	6268
Eif4a1	6253
Rps20	6232
Rpl12	6198
Rps4x	5999
Eif3k	5919
Rpsa	5712
Rpl6	5583
Eif3d	5574
Eif3f	5282
Eif2b4	5067
Eif5	5019
Eif4e	4744
Eif3l	4682
Eif2s2	4515
Eif4a2	4494
Eif4h	4352
Eif3e	4145
Eif4ebp1	4008
Eif2b5	3736
Eif5b	2307
Eif3c	2238
Rpl10	2228
Eif3b	204
Eif1ax	-705
Eif2s3x	-729
Eif4b	-764
Eif2b3	-1065
Pabpc1	-2626
Eif4g1	-4562
Eif3a	-5496
Eif3j2	-7834

---

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

FORMATION OF ATP BY CHEMIOSMOTIC COUPLING

	331
set	FORMATION OF ATP BY CHEMIOSMOTIC COUPLING
setSize	18
pANOVA	4.11e-08
s.dist	0.747
p.adjustANOVA	7.82e-07

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atp5k	8246
Atp5g1	8061
Atp5j	8037
Atp5e	8029
Atp5j2	7996
mt-Atp8	7872
Atp5g3	7732
Atp5pb	7715
Atp5c1	7702
Atp5h	7646
Atp5l	7551
Atp5o	7535
Atp5b	7287
Atp5d	7201
Dmac2l	5595
Atp5a1	2242
mt-Atp6	117
Atp5g2	-7609

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atp5k	8246
Atp5g1	8061
Atp5j	8037
Atp5e	8029
Atp5j2	7996
mt-Atp8	7872
Atp5g3	7732
Atp5pb	7715
Atp5c1	7702
Atp5h	7646
Atp5l	7551
Atp5o	7535
Atp5b	7287
Atp5d	7201
Dmac2l	5595
Atp5a1	2242
mt-Atp6	117
Atp5g2	-7609

---

ADENYLATE CYCLASE ACTIVATING PATHWAY

ADENYLATE CYCLASE ACTIVATING PATHWAY

	36
set	ADENYLATE CYCLASE ACTIVATING PATHWAY
setSize	10
pANOVA	4.94e-05
s.dist	-0.741
p.adjustANOVA	0.000438

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Adcy6	-8795
Adcy3	-7802
Adcy5	-7709
Adcy8	-7344
Gnal	-7090
Adcy2	-6526
Adcy9	-4486
Adcy1	-640

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Adcy6	-8795
Adcy3	-7802
Adcy5	-7709
Adcy8	-7344
Gnal	-7090
Adcy2	-6526
Adcy9	-4486
Adcy1	-640

---

COMPLEX I BIOGENESIS

COMPLEX I BIOGENESIS

	172
set	COMPLEX I BIOGENESIS
setSize	56
pANOVA	6.16e-21
s.dist	0.725
p.adjustANOVA	3.64e-19

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ndufb1	8224
Ndufa1	8209
Ndufa3	8206
Ndufa2	8193
Ndufc1	8100
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051
Ndufs5	8023
Ndufb9	8002
Ndufb3	7998
Ndufs4	7985
Ndufa6	7968
Ndufc2	7955
Ndufb8	7931
Ndufaf2	7875
Ndufa11	7874
Ndufa7	7857
Ndufb7	7734
Ndufa12	7696

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ndufb1	8224
Ndufa1	8209
Ndufa3	8206
Ndufa2	8193
Ndufc1	8100
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051
Ndufs5	8023
Ndufb9	8002
Ndufb3	7998
Ndufs4	7985
Ndufa6	7968
Ndufc2	7955
Ndufb8	7931
Ndufaf2	7875
Ndufa11	7874
Ndufa7	7857
Ndufb7	7734
Ndufa12	7696
Ndufv3	7667
Ndufab1	7639
Ndufv2	7630
Timmdc1	7567
Ndufs2	7533
Ndufv1	7518
Ndufb10	7509
Ndufb2	7466
Ndufb5	7429
Ndufb6	7399
Ndufb11	7389
Ndufs8	7370
Nubpl	7321
Ndufaf3	7290
Ndufb4	7263
Tmem186	7110
Ndufaf6	6943
Ndufa10	6876
Ndufs3	6805
Ndufa8	6782
Tmem126b	6712
Ndufs7	6616
Ndufaf5	6479
Ndufa9	6396
Ndufaf7	5975
mt-Nd3	5608
Ndufaf1	5059
Ecsit	3430
Ndufaf4	3377
Ndufs1	1403
mt-Nd6	108
Acad9	-1666
mt-Nd1	-4019
mt-Nd4	-7084
mt-Nd5	-8584
mt-Nd2	-8859

---

SELENOAMINO ACID METABOLISM

SELENOAMINO ACID METABOLISM

	914
set	SELENOAMINO ACID METABOLISM
setSize	108
pANOVA	2.53e-38
s.dist	0.72
p.adjustANOVA	3.32e-36

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Pstk	7909
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Pstk	7909
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Rpl30	7145
Rpl8	7137
Rps13	7086
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Aimp1	6838
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpl27a	6473
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Hnmt	6205
Rpl12	6198
Rps4x	5999
Rpsa	5712
Rars	5661
Aimp2	5587
Rpl6	5583
Sars	5488
Kars	4985
Gnmt	4925
Ahcy	4336
Sephs2	4018
Eef1e1	3982
Cbs	3934
Lars	3073
Rpl10	2228
Sepsecs	1756
Scly	1184
Dars	1026
Eprs	817
Mars1	200
Qars	-1167
Gsr	-1485
Secisbp2	-1908
Eefsec	-2058
Papss1	-3074
Cth	-4528
Txnrd1	-4597
Papss2	-5124
Iars	-7028

---

RESPIRATORY ELECTRON TRANSPORT

RESPIRATORY ELECTRON TRANSPORT

	837
set	RESPIRATORY ELECTRON TRANSPORT
setSize	102
pANOVA	2.25e-34
s.dist	0.7
p.adjustANOVA	2.04e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Ndufb1	8224
Ndufa1	8209
Ndufa3	8206
Cox7c	8197
Cox8a	8196
Ndufa2	8193
Uqcrq	8158
Ndufa4	8129
Uqcr11	8116
Ndufc1	8100
Uqcr10	8099
Cox6c	8086
Cox6b1	8069
Cox5b	8059
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051
Cox14	8038
Cox5a	8028
Ndufs5	8023

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Ndufb1	8224
Ndufa1	8209
Ndufa3	8206
Cox7c	8197
Cox8a	8196
Ndufa2	8193
Uqcrq	8158
Ndufa4	8129
Uqcr11	8116
Ndufc1	8100
Uqcr10	8099
Cox6c	8086
Cox6b1	8069
Cox5b	8059
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051
Cox14	8038
Cox5a	8028
Ndufs5	8023
Cox7b	8014
Ndufb9	8002
Ndufb3	7998
Ndufs4	7985
Ndufa6	7968
Ndufc2	7955
Ndufb8	7931
Cox4i1	7897
Cox6a1	7893
Ndufaf2	7875
Ndufa11	7874
Sdhd	7866
Ndufa7	7857
Cyc1	7848
Uqcrh	7843
Uqcrb	7828
Uqcrc1	7775
Ndufb7	7734
Ndufa12	7696
Ndufv3	7667
Ndufab1	7639
Ndufv2	7630
Uqcrfs1	7578
Timmdc1	7567
Ndufs2	7533
Surf1	7526
Ndufv1	7518
Ndufb10	7509
Ndufb2	7466
Ndufb5	7429
Ndufb6	7399
Ndufb11	7389
Ndufs8	7370
Nubpl	7321
Ndufaf3	7290
Ndufb4	7263
Etfb	7230
Cox16	7173
Tmem186	7110
Cox20	7109
Cox7a2l	6959
Ndufaf6	6943
Ndufa10	6876
Ndufs3	6805
Ndufa8	6782
Tmem126b	6712
Sdhb	6683
Cox19	6625
Ndufs7	6616
Ndufaf5	6479
Uqcrc2	6477
Ndufa9	6396
Coq10a	6250
Cycs	6115
Ndufaf7	5975
mt-Nd3	5608
Etfa	5550
Etfdh	5529
Sdhc	5132
Ndufaf1	5059
Trap1	4600
Cox11	4162
mt-Co3	4094
Cox18	3590
Ecsit	3430
Ndufaf4	3377
Sco2	2254
Ndufs1	1403
mt-Nd6	108
Sco1	-24
Sdha	-346
mt-Co2	-461
Acad9	-1666
Lrpprc	-1807
Coq10b	-1846
mt-Cytb	-3144
mt-Nd1	-4019
Taco1	-4549
mt-Co1	-5320
mt-Nd4	-7084
mt-Nd5	-8584
mt-Nd2	-8859

---

CRISTAE FORMATION

CRISTAE FORMATION

	189
set	CRISTAE FORMATION
setSize	31
pANOVA	2.45e-11
s.dist	0.692
p.adjustANOVA	8.28e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atp5k	8246
Atp5g1	8061
Atp5j	8037
Atp5e	8029
Apoo	8027
Atp5j2	7996
Micos13	7904
mt-Atp8	7872
Chchd3	7851
Atp5g3	7732
Atp5pb	7715
Atp5c1	7702
Atp5h	7646
Mtx1	7558
Atp5l	7551
Atp5o	7535
Tmem11	7481
Chchd6	7383
Atp5b	7287
Atp5d	7201

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atp5k	8246
Atp5g1	8061
Atp5j	8037
Atp5e	8029
Apoo	8027
Atp5j2	7996
Micos13	7904
mt-Atp8	7872
Chchd3	7851
Atp5g3	7732
Atp5pb	7715
Atp5c1	7702
Atp5h	7646
Mtx1	7558
Atp5l	7551
Atp5o	7535
Tmem11	7481
Chchd6	7383
Atp5b	7287
Atp5d	7201
Micos10	6921
Mtx2	6163
Dmac2l	5595
Apool	3953
Immt	2725
Atp5a1	2242
Dnajc11	444
mt-Atp6	117
Hspa9	-454
Samm50	-1966
Atp5g2	-7609

---

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS

	838
set	RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS
setSize	125
pANOVA	1.74e-40
s.dist	0.689
p.adjustANOVA	2.93e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atp5k	8246
Ndufb1	8224
Ucp2	8219
Ndufa1	8209
Ndufa3	8206
Cox7c	8197
Cox8a	8196
Ndufa2	8193
Uqcrq	8158
Ndufa4	8129
Uqcr11	8116
Ndufc1	8100
Uqcr10	8099
Cox6c	8086
Cox6b1	8069
Atp5g1	8061
Cox5b	8059
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atp5k	8246
Ndufb1	8224
Ucp2	8219
Ndufa1	8209
Ndufa3	8206
Cox7c	8197
Cox8a	8196
Ndufa2	8193
Uqcrq	8158
Ndufa4	8129
Uqcr11	8116
Ndufc1	8100
Uqcr10	8099
Cox6c	8086
Cox6b1	8069
Atp5g1	8061
Cox5b	8059
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051
Cox14	8038
Atp5j	8037
Atp5e	8029
Cox5a	8028
Ndufs5	8023
Cox7b	8014
Ndufb9	8002
Ndufb3	7998
Atp5j2	7996
Ndufs4	7985
Ndufa6	7968
Ndufc2	7955
Ndufb8	7931
Cox4i1	7897
Cox6a1	7893
Ndufaf2	7875
Ndufa11	7874
mt-Atp8	7872
Sdhd	7866
Ndufa7	7857
Cyc1	7848
Uqcrh	7843
Uqcrb	7828
Uqcrc1	7775
Ndufb7	7734
Atp5g3	7732
Atp5pb	7715
Atp5c1	7702
Ndufa12	7696
Ndufv3	7667
Ucp3	7660
Atp5h	7646
Ndufab1	7639
Ndufv2	7630
Uqcrfs1	7578
Timmdc1	7567
Atp5l	7551
Atp5o	7535
Ndufs2	7533
Surf1	7526
Ndufv1	7518
Ndufb10	7509
Ndufb2	7466
Ndufb5	7429
Ndufb6	7399
Ndufb11	7389
Ndufs8	7370
Nubpl	7321
Ndufaf3	7290
Atp5b	7287
Ndufb4	7263
Etfb	7230
Atp5d	7201
Cox16	7173
Tmem186	7110
Cox20	7109
Cox7a2l	6959
Ndufaf6	6943
Ndufa10	6876
Ndufs3	6805
Ndufa8	6782
Tmem126b	6712
Sdhb	6683
Cox19	6625
Ndufs7	6616
Ndufaf5	6479
Uqcrc2	6477
Ndufa9	6396
Coq10a	6250
Cycs	6115
Ndufaf7	5975
mt-Nd3	5608
Dmac2l	5595
Etfa	5550
Etfdh	5529
Sdhc	5132
Ndufaf1	5059
Slc25a14	4843
Trap1	4600
Cox11	4162
mt-Co3	4094
Cox18	3590
Ecsit	3430
Ndufaf4	3377
Sco2	2254
Atp5a1	2242
Ndufs1	1403
mt-Atp6	117
mt-Nd6	108
Sco1	-24
Sdha	-346
mt-Co2	-461
Acad9	-1666
Lrpprc	-1807
Coq10b	-1846
mt-Cytb	-3144
mt-Nd1	-4019
Taco1	-4549
mt-Co1	-5320
Slc25a27	-5449
mt-Nd4	-7084
Atp5g2	-7609
Pm20d1	-7755
mt-Nd5	-8584
mt-Nd2	-8859

---

NONSENSE MEDIATED DECAY NMD

NONSENSE MEDIATED DECAY NMD

	635
set	NONSENSE MEDIATED DECAY NMD
setSize	109
pANOVA	6.67e-34
s.dist	0.672
p.adjustANOVA	5.62e-32

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Magoh	7916
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Magoh	7916
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Magohb	7626
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Rpl30	7145
Rpl8	7137
Rps13	7086
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Eif4a3	6842
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpl27a	6473
Smg9	6401
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Rps4x	5999
Ncbp2	5725
Rpsa	5712
Rpl6	5583
Ppp2ca	5554
Upf3a	5389
Smg5	4871
Upf3b	3070
Pnrc2	2996
Etf1	2515
Rbm8a	2513
Rpl10	2228
Upf2	1989
Rnps1	1394
Ncbp1	1338
Ppp2r1a	325
Ppp2r2a	-1793
Pabpc1	-2626
Smg8	-4329
Eif4g1	-4562
Dcp1a	-4652
Gspt2	-5434
Gspt1	-5841
Casc3	-5851
Upf1	-6569
Smg6	-6698
Smg1	-8022
Smg7	-8241

---

ADENYLATE CYCLASE INHIBITORY PATHWAY

ADENYLATE CYCLASE INHIBITORY PATHWAY

	37
set	ADENYLATE CYCLASE INHIBITORY PATHWAY
setSize	13
pANOVA	2.94e-05
s.dist	-0.669
p.adjustANOVA	0.000284

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Adcy6	-8795
Adcy3	-7802
Adcy5	-7709
Adcy8	-7344
Gnal	-7090
Adcy2	-6526
Gnai3	-5032
Gnai1	-4880
Adcy9	-4486
Gnai2	-2502
Adcy1	-640

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Adcy6	-8795
Adcy3	-7802
Adcy5	-7709
Adcy8	-7344
Gnal	-7090
Adcy2	-6526
Gnai3	-5032
Gnai1	-4880
Adcy9	-4486
Gnai2	-2502
Adcy1	-640

---

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S

	28
set	ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S
setSize	59
pANOVA	1.24e-18
s.dist	0.663
p.adjustANOVA	6.67e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rps27	8135
Rps28	8081
Fau	7889
Rps17	7858
Rps14	7821
Rps15	7805
Rps10	7793
Rps12	7721
Rps8	7676
Rps23	7560
Rps27a	7519
Rps18	7494
Eif3g	7476
Rps7	7471
Rps9	7456
Rps15a	7440
Rps19	7268
Eif3i	7245

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rps27	8135
Rps28	8081
Fau	7889
Rps17	7858
Rps14	7821
Rps15	7805
Rps10	7793
Rps12	7721
Rps8	7676
Rps23	7560
Rps27a	7519
Rps18	7494
Eif3g	7476
Rps7	7471
Rps9	7456
Rps15a	7440
Rps19	7268
Eif3i	7245
Eif3m	7176
Rps13	7086
Rps16	6913
Rps2	6912
Rps11	6883
Rps25	6881
Rps3	6754
Eif3h	6729
Rps27l	6682
Rps6	6648
Rps24	6631
Rps5	6627
Eif3j1	6602
Eif2s1	6435
Rps26	6384
Rps3a1	6345
Eif4a1	6253
Rps20	6232
Rps4x	5999
Eif3k	5919
Rpsa	5712
Eif3d	5574
Eif3f	5282
Eif4e	4744
Eif3l	4682
Eif2s2	4515
Eif4a2	4494
Eif4h	4352
Eif3e	4145
Eif4ebp1	4008
Eif3c	2238
Eif3b	204
Eif1ax	-705
Eif2s3x	-729
Eif4b	-764
Pabpc1	-2626
Eif4g1	-4562
Eif3a	-5496
Eif3j2	-7834

---

MITOCHONDRIAL PROTEIN IMPORT

MITOCHONDRIAL PROTEIN IMPORT

	571
set	MITOCHONDRIAL PROTEIN IMPORT
setSize	63
pANOVA	5.96e-19
s.dist	0.647
p.adjustANOVA	3.35e-17

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Tomm7	8227
Timm13	8160
Dnajc19	8153
Atp5g1	8061
Cox17	8040
Grpel1	7986
Timm8b	7974
Pam16	7971
Tomm22	7943
Ndufb8	7931
Timm23	7881
Chchd3	7851
Cyc1	7848
Timm10	7750
Tomm6	7722
Timm10b	7591
Mtx1	7558
Chchd10	7472
Tomm5	7349
Atp5b	7287

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Tomm7	8227
Timm13	8160
Dnajc19	8153
Atp5g1	8061
Cox17	8040
Grpel1	7986
Timm8b	7974
Pam16	7971
Tomm22	7943
Ndufb8	7931
Timm23	7881
Chchd3	7851
Cyc1	7848
Timm10	7750
Tomm6	7722
Timm10b	7591
Mtx1	7558
Chchd10	7472
Tomm5	7349
Atp5b	7287
Timm22	7105
Idh3g	7082
Timm9	7019
Fxn	6879
Coq2	6837
Timm21	6826
Timm8a1	6812
Chchd7	6705
Chchd4	6695
Tomm40	6684
Cox19	6625
Hscb	6603
Slc25a13	6600
Slc25a4	6365
Cmc2	6347
Timm50	6282
Chchd5	6197
Pmpca	6174
Mtx2	6163
Chchd2	5973
Ldhd	5861
Timm44	5723
Coa4	5611
Pmpcb	5609
Timm17a	5567
Grpel2	5382
Gfer	5262
Vdac1	5077
Timm17b	4318
Coa6	4242
Cmc4	3107
Aco2	2503
Atp5a1	2242
Taz	1571
Cs	698
Tomm20	206
Hspa9	-454
Bcs1l	-627
Samm50	-1966
Tomm70a	-2163
Slc25a12	-6200
Hspd1	-6898
Pitrm1	-7222

---

MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS

MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS

	570
set	MITOCHONDRIAL IRON SULFUR CLUSTER BIOGENESIS
setSize	13
pANOVA	6.83e-05
s.dist	0.638
p.adjustANOVA	0.00058

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Lyrm4	7510
Glrx5	7394
Fdx1	7071
Fxn	6879
Iscu	6607
Hscb	6603
Fdx2	6508
Nfs1	6293
Isca1	5556
Fdxr	4994
Isca2	4714
Slc25a28	4388
Slc25a37	-8075

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Lyrm4	7510
Glrx5	7394
Fdx1	7071
Fxn	6879
Iscu	6607
Hscb	6603
Fdx2	6508
Nfs1	6293
Isca1	5556
Fdxr	4994
Isca2	4714
Slc25a28	4388
Slc25a37	-8075

---

TRANSLATION

TRANSLATION

	1131
set	TRANSLATION
setSize	286
pANOVA	2e-73
s.dist	0.621
p.adjustANOVA	2.36e-70

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Mrpl58	8214
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Mrps28	8103
Mrps21	8096
Rps28	8081
Rpl36	8077
Mrpl52	8073
Rpl22	8043
Rpl37a	8035
Sec61b	8019
Rpl32	8005
Mrpl2	7995
Mrpl54	7979
Mrpl53	7963
Mrpl20	7935

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Mrpl58	8214
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Mrps28	8103
Mrps21	8096
Rps28	8081
Rpl36	8077
Mrpl52	8073
Rpl22	8043
Rpl37a	8035
Sec61b	8019
Rpl32	8005
Mrpl2	7995
Mrpl54	7979
Mrpl53	7963
Mrpl20	7935
Gadd45gip1	7925
Mrps26	7914
Mrps34	7892
Fau	7889
Rpl35	7880
Rplp2	7877
Mrpl41	7862
Rps17	7858
Mrps18c	7852
Rpl37	7845
Mrps33	7840
Rps14	7821
Rpl36al	7817
Rpl19	7814
Mrps16	7811
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Mrpl30	7759
Rpl31	7729
Rpl34	7726
Rps12	7721
Mrpl51	7714
Sec11c	7713
Rpl26	7699
Mrps12	7682
Rps8	7676
N6amt1	7672
Ppa2	7666
Rplp1	7662
Mrps24	7658
Rpl23	7655
Rpl27	7644
Mrpl9	7634
Mrpl44	7629
Mrpl48	7613
Rpl7a	7609
Aurkaip1	7607
Rpl24	7605
Mrpl40	7597
Mrpl43	7584
Rps23	7560
Rps27a	7519
Rpl36a	7511
Mrpl11	7504
Rps18	7494
Rpl18	7478
Eif3g	7476
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Mrpl27	7435
Mrpl28	7434
Mrps27	7433
Srp9	7428
Rpl9	7416
Mrpl21	7329
Mrpl14	7319
Mrpl1	7306
Rpl21	7270
Rps19	7268
Mrpl12	7266
Uba52	7262
Rpl29	7250
Eif3i	7245
Mrpl39	7228
Mrps23	7220
Mrpl13	7209
Eif3m	7176
Mrpl33	7159
Mrpl49	7147
Rpl30	7145
Mrps36	7138
Rpl8	7137
Mrpl34	7119
Rps13	7086
Srp14	7072
Sec61g	7020
Rplp0	7009
Mrps10	6998
Mrpl23	6996
Mrpl55	6981
Rpl10a	6965
Mrps14	6937
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Mrps7	6882
Rps25	6881
Mrpl46	6880
Rpl14	6873
Mrps9	6863
Mrpl42	6852
Sec11a	6840
Aimp1	6838
Spcs1	6830
Mrps15	6821
Eef1d	6818
Mrpl15	6817
Mrps17	6815
Eef1b2	6809
Rpl13a	6776
Mrpl35	6775
Rpl4	6774
Rps3	6754
Tsfm	6732
Eif3h	6729
Rps27l	6682
Mrpl57	6671
Eif2b1	6658
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Eif3j1	6602
Mrpl17	6518
Mrpl18	6485
Rpl27a	6473
Ssr4	6450
Eif2s1	6435
Rps26	6384
Mrpl16	6368
Rps3a1	6345
Mtfmt	6338
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rars2	6273
Eif2b2	6268
Eif4a1	6253
Rps20	6232
Mrps18b	6221
Rpl12	6198
Mrpl36	6087
Yars2	6083
Eef1g	6077
Mrps22	6072
Rps4x	5999
Mrpl32	5936
Ssr2	5935
Eif3k	5919
Srp19	5834
Eef1a1	5792
Trmt112	5791
Mrps35	5721
Mrps18a	5714
Rpsa	5712
Mrps6	5692
Mrpl22	5672
Rars	5661
Mrrf	5635
Mrpl38	5614
Aimp2	5587
Rpl6	5583
Eif3d	5574
Mtif3	5553
Fars2	5540
Sars	5488
Eral1	5486
Sars2	5476
Mrpl50	5286
Eif3f	5282
Srprb	5181
Mrpl10	5121
Chchd1	5107
Mrps25	5084
Eif2b4	5067
Eif5	5019
Mrpl3	5004
Kars	4985
Mrps11	4972
Mrpl47	4959
Mtif2	4929
Mrpl19	4784
Eif4e	4744
Eif3l	4682
Mrpl4	4557
Eif2s2	4515
Ppa1	4510
Eif4a2	4494
Spcs2	4468
Eif4h	4352
Tufm	4339
Eif3e	4145
Eif4ebp1	4008
Eef1e1	3982
Mrpl24	3938
Eif2b5	3736
Mrpl37	3706
Dap3	3603
Mrps2	3578
Farsa	3491
Apeh	3393
Lars2	3277
Cars	3177
Mrps30	3131
Lars	3073
Ddost	2939
Tars2	2879
Nars	2868
Ssr3	2761
Etf1	2515
Oxa1l	2368
Eif5b	2307
Eif3c	2238
Rpl10	2228
Hars2	2071
Wars	1893
Gfm1	1820
Srp54a	1716
Mrps31	1637
Mrps5	1615
Ptcd3	1490
Eef2	1448
Sec61a2	1290
Nars2	1268
Rpn1	1064
Dars	1026
Sec61a1	997
Eprs	817
Gars	592
Vars	564
Farsb	497
Tars	364
Yars	324
Eif3b	204
Mars1	200
Eef1a2	159
Iars2	143
Spcs3	5
Cars2	-17
Hars	-165
Eif1ax	-705
Eif2s3x	-729
Eif4b	-764
Dars2	-909
Aars2	-994
Eif2b3	-1065
Qars	-1167
Srp68	-1233
Rpn2	-1692
Pabpc1	-2626
Ssr1	-2771
Eif4g1	-4562
Mtrf1l	-4850
Gspt2	-5434
Eif3a	-5496
Srpr	-5713
Gspt1	-5841
Aars	-5931
Mars2	-6102
Pars2	-6176
Srp72	-6413
Tram1	-6559
Iars	-7028
Gfm2	-7057
Ears2	-7757
Eif3j2	-7834
Wars2	-8725
Vars2	-8832

---

PKA MEDIATED PHOSPHORYLATION OF CREB

PKA MEDIATED PHOSPHORYLATION OF CREB

	711
set	PKA MEDIATED PHOSPHORYLATION OF CREB
setSize	19
pANOVA	3.08e-06
s.dist	-0.618
p.adjustANOVA	4.08e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Prkar2a	-8858
Adcy6	-8795
Creb1	-8717
Adcy3	-7802
Adcy5	-7709
Prkx	-7616
Adcy8	-7344
Prkacb	-7235
Nbea	-6617
Adcy2	-6526
Adcy9	-4486
Prkar2b	-3762
Prkar1a	-3133
Prkar1b	-1887
Prkaca	-1090
Adcy1	-640
Calm1	533

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Prkar2a	-8858
Adcy6	-8795
Creb1	-8717
Adcy3	-7802
Adcy5	-7709
Prkx	-7616
Adcy8	-7344
Prkacb	-7235
Nbea	-6617
Adcy2	-6526
Adcy9	-4486
Prkar2b	-3762
Prkar1a	-3133
Prkar1b	-1887
Prkaca	-1090
Adcy1	-640
Calm1	533

---

RNA POLYMERASE III CHAIN ELONGATION

RNA POLYMERASE III CHAIN ELONGATION

	883
set	RNA POLYMERASE III CHAIN ELONGATION
setSize	18
pANOVA	8.72e-06
s.dist	0.605
p.adjustANOVA	9.99e-05

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Polr2l	8217
Polr3e	8026
Polr2f	7953
Polr2h	7653
Polr3h	7489
Polr2k	7373
Polr1c	7063
Polr1d	7027
Crcp	7012
Polr2e	7011
Polr3d	6079
Polr3c	5729
Polr3k	4182
Polr3gl	3984
Polr3b	1909
Polr3f	-424
Polr3g	-1536
Polr3a	-7849

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Polr2l	8217
Polr3e	8026
Polr2f	7953
Polr2h	7653
Polr3h	7489
Polr2k	7373
Polr1c	7063
Polr1d	7027
Crcp	7012
Polr2e	7011
Polr3d	6079
Polr3c	5729
Polr3k	4182
Polr3gl	3984
Polr3b	1909
Polr3f	-424
Polr3g	-1536
Polr3a	-7849

---

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT

	1072
set	THE CITRIC ACID TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT
setSize	172
pANOVA	1.71e-40
s.dist	0.588
p.adjustANOVA	2.93e-38

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Atp5k	8246
Ndufb1	8224
Ucp2	8219
Ndufa1	8209
Ndufa3	8206
Cox7c	8197
Cox8a	8196
Ndufa2	8193
Mpc2	8161
Uqcrq	8158
Ndufa4	8129
Uqcr11	8116
Ndufc1	8100
Uqcr10	8099
Cox6c	8086
Cox6b1	8069
Atp5g1	8061
Cox5b	8059
Ndufa5	8056
Ndufa13	8055

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Atp5k	8246
Ndufb1	8224
Ucp2	8219
Ndufa1	8209
Ndufa3	8206
Cox7c	8197
Cox8a	8196
Ndufa2	8193
Mpc2	8161
Uqcrq	8158
Ndufa4	8129
Uqcr11	8116
Ndufc1	8100
Uqcr10	8099
Cox6c	8086
Cox6b1	8069
Atp5g1	8061
Cox5b	8059
Ndufa5	8056
Ndufa13	8055
Ndufs6	8051
Ldhb	8049
Cox14	8038
Atp5j	8037
Atp5e	8029
Cox5a	8028
Ndufs5	8023
Cox7b	8014
Ndufb9	8002
Ndufb3	7998
Atp5j2	7996
Ndufs4	7985
Ndufa6	7968
Ndufc2	7955
Ndufb8	7931
Idh3b	7900
Cox4i1	7897
Cox6a1	7893
Ndufaf2	7875
Ndufa11	7874
mt-Atp8	7872
Sdhd	7866
Ndufa7	7857
Cyc1	7848
Uqcrh	7843
Uqcrb	7828
Uqcrc1	7775
Ndufb7	7734
Atp5g3	7732
Atp5pb	7715
Atp5c1	7702
Ndufa12	7696
Ndufv3	7667
Ucp3	7660
Atp5h	7646
Ndufab1	7639
Ndufv2	7630
Uqcrfs1	7578
Timmdc1	7567
Atp5l	7551
Pdhb	7550
Atp5o	7535
Ndufs2	7533
Surf1	7526
Ndufv1	7518
Ndufb10	7509
Ndufb2	7466
Ndufb5	7429
Ndufb6	7399
Ndufb11	7389
Suclg1	7384
Mpc1	7371
Ndufs8	7370
Nubpl	7321
Ndufaf3	7290
Atp5b	7287
Ndufb4	7263
Etfb	7230
Atp5d	7201
Cox16	7173
Tmem186	7110
Cox20	7109
Idh3g	7082
Hagh	6971
Cox7a2l	6959
Fahd1	6950
Ndufaf6	6943
Ndufa10	6876
Ndufs3	6805
Ndufa8	6782
Tmem126b	6712
Sdhb	6683
Cox19	6625
Ndufs7	6616
Sucla2	6578
Ndufaf5	6479
Uqcrc2	6477
Ndufa9	6396
Gstz1	6366
Coq10a	6250
Cycs	6115
Pdk4	6000
Ndufaf7	5975
Fh1	5948
Mdh2	5641
mt-Nd3	5608
Dmac2l	5595
Idh3a	5585
Etfa	5550
Etfdh	5529
Idh2	5190
Sdhc	5132
Vdac1	5077
Ndufaf1	5059
D2hgdh	4933
Slc25a14	4843
Trap1	4600
Pdhx	4176
Cox11	4162
mt-Co3	4094
Pdk2	3886
Cox18	3590
Glo1	3431
Ecsit	3430
Ndufaf4	3377
Ldha	3351
Me1	3307
Pdha1	2836
Bsg	2733
Dld	2564
Aco2	2503
Me3	2429
Sco2	2254
Atp5a1	2242
Dlst	1937
Ndufs1	1403
Slc16a3	1099
Suclg2	819
Adhfe1	710
Cs	698
Dlat	495
Ppard	254
L2hgdh	184
mt-Atp6	117
mt-Nd6	108
Sco1	-24
Sdha	-346
Pdk1	-353
mt-Co2	-461
Me2	-890
Acad9	-1666
Lrpprc	-1807
Coq10b	-1846
Pdp2	-2053
mt-Cytb	-3144
Pdk3	-3687
mt-Nd1	-4019
Slc16a8	-4207
Taco1	-4549
Slc16a1	-4799
Nnt	-5258
mt-Co1	-5320
Ogdh	-5395
Slc25a27	-5449
Pdpr	-6351
Rxra	-6734
mt-Nd4	-7084
Atp5g2	-7609
Pm20d1	-7755
mt-Nd5	-8584
mt-Nd2	-8859
Pdp1	-8911

---

NEGATIVE REGULATION OF NOTCH4 SIGNALING

NEGATIVE REGULATION OF NOTCH4 SIGNALING

	612
set	NEGATIVE REGULATION OF NOTCH4 SIGNALING
setSize	54
pANOVA	9.51e-14
s.dist	0.586
p.adjustANOVA	4.31e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Rbx1	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Rbx1	6958
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Tacc3	6339
Psmc1	6270
Notch4	6122
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Skp1	4875
Psmd12	3996
Akt1	3834
Psmc6	3784
Psmd10	3670
Psmf1	3034
Psmd6	2341
Psmb8	1878
Psmd1	1686
Psmd2	-281
Fbxw7	-894
Psmb9	-1520
Ubc	-2250
Cul1	-2566
Ywhaz	-3960
Psme3	-4000
Psmd11	-4032
Psmd5	-4580

---

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

REGULATION OF RUNX1 EXPRESSION AND ACTIVITY

	818
set	REGULATION OF RUNX1 EXPRESSION AND ACTIVITY
setSize	17
pANOVA	3.14e-05
s.dist	-0.583
p.adjustANOVA	0.000299

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Mov10	-8985
Ccnd2	-8853
Ago3	-8733
Ago2	-8551
Cdk6	-8201
Ago1	-8048
Tnrc6a	-7926
Tnrc6c	-7641
Tnrc6b	-6445
Ccnd1	-5372
Ago4	-5091
Cbfb	-4841
Pml	-4147
Src	-3681
Ccnd3	89
Runx1	490
Ptpn11	2900

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Mov10	-8985
Ccnd2	-8853
Ago3	-8733
Ago2	-8551
Cdk6	-8201
Ago1	-8048
Tnrc6a	-7926
Tnrc6c	-7641
Tnrc6b	-6445
Ccnd1	-5372
Ago4	-5091
Cbfb	-4841
Pml	-4147
Src	-3681
Ccnd3	89
Runx1	490
Ptpn11	2900

---

REGULATION OF EXPRESSION OF SLITS AND ROBOS

REGULATION OF EXPRESSION OF SLITS AND ROBOS

	793
set	REGULATION OF EXPRESSION OF SLITS AND ROBOS
setSize	162
pANOVA	1.75e-37
s.dist	0.582
p.adjustANOVA	1.88e-35

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Psmb5	8036
Rpl37a	8035
Rpl32	8005
Magoh	7916
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Psma3	7831
Psmb3	7826

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Psmb5	8036
Rpl37a	8035
Rpl32	8005
Magoh	7916
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Psma3	7831
Psmb3	7826
Rps14	7821
Rpl36al	7817
Rpl19	7814
Psmb7	7813
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Rpl26	7699
Psmb2	7679
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Sem1	7641
Magohb	7626
Rpl7a	7609
Rpl24	7605
Psmb6	7604
Rps23	7560
Psmd9	7553
Psma7	7531
Rps27a	7519
Rpl36a	7511
Psma4	7495
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Psmd13	7414
Psmb4	7374
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Rpl30	7145
Rpl8	7137
Rps13	7086
Psmd7	7050
Rplp0	7009
Rpl10a	6965
Rbx1	6958
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Psma2	6851
Eif4a3	6842
Psme1	6829
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Psmb10	6606
Rpl17	6604
Psmd8	6594
Eloc	6528
Rpl27a	6473
Psmb1	6446
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Psmc1	6270
Rps20	6232
Elob	6216
Rpl12	6198
Rps4x	5999
Psmc2	5913
Psmd14	5733
Ncbp2	5725
Rpsa	5712
Psmc5	5693
Psmc3	5625
Rpl6	5583
Psmd4	5559
Lhx3	5449
Upf3a	5389
Psma1	5378
Psme2	5280
Psma5	5259
Psmd12	3996
Psmc6	3784
Psmd10	3670
Upf3b	3070
Psmf1	3034
Etf1	2515
Rbm8a	2513
Psmd6	2341
Rpl10	2228
Upf2	1989
Psmb8	1878
Psmd1	1686
Cul2	1613
Rnps1	1394
Ncbp1	1338
Psmd2	-281
Ldb1	-553
Psmb9	-1520
Ubc	-2250
Pabpc1	-2626
Psme3	-4000
Psmd11	-4032
Eif4g1	-4562
Psmd5	-4580
Psme4	-4962
Isl1	-5035
Robo2	-5272
Gspt2	-5434
Gspt1	-5841
Msi1	-5844
Casc3	-5851
Col4a5	-6422
Slit2	-6451
Lhx4	-6621
Dag1	-6855
Robo3	-7106
Usp33	-7892
Slit1	-7905
Robo1	-8470
Zswim8	-8764
Lhx9	-8779
Lhx2	-8991

---

CELLULAR RESPONSE TO STARVATION

CELLULAR RESPONSE TO STARVATION

	141
set	CELLULAR RESPONSE TO STARVATION
setSize	146
pANOVA	1.09e-32
s.dist	0.57
p.adjustANOVA	8.03e-31

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Lamtor1	8184
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Lamtor4	8058
Rpl22	8043
Rpl37a	8035
Castor1	8025
Rpl32	8005
Lamtor3	7926
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Lamtor1	8184
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Lamtor4	8058
Rpl22	8043
Rpl37a	8035
Castor1	8025
Rpl32	8005
Lamtor3	7926
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Atf4	7703
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Atp6v1f	7647
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Atp6v1g1	7387
Lamtor2	7296
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Lamtor5	7208
Sesn1	7206
Rpl30	7145
Rpl8	7137
Rps13	7086
Rplp0	7009
Atp6v0b	6969
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Atp6v1e1	6861
Kptn	6848
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpl27a	6473
Eif2s1	6435
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Sec13	6081
Rps4x	5999
Rpsa	5712
Ddit3	5632
Rpl6	5583
Atp6v0d1	5492
Atp6v1g2	5253
Nprl2	5244
Mlst8	4656
Atp6v1c1	4617
Eif2s2	4515
Atp6v1d	4360
Rraga	4343
Atp6v0e2	4214
Atp6v1h	3848
Atp6v0c	3691
Rragc	3568
Rheb	3534
Mios	3055
BC048403	2337
Atp6v0e	2264
Rpl10	2228
Wdr24	1889
Cebpb	1745
Atp6v1b2	971
Atp6v1c2	578
Trib3	491
Atf3	449
Itfg2	340
Nprl3	-451
Cebpg	-545
Eif2s3x	-729
Rragb	-927
Seh1l	-1259
Fnip2	-1349
Atp6v1a	-1401
Sesn2	-1515
Asns	-1790
Rptor	-2954
Wdr59	-3778
Depdc5	-5135
Eif2ak4	-5310
Sh3bp4	-5647
Tcirg1	-5687
Impact	-5768
Flcn	-6012
Fnip1	-6592
Mtor	-6812
Bmt2	-6893
Gcn1	-7117
Szt2	-7355
Slc38a9	-7362
Atf2	-7475
Castor2	-7604
Rragd	-8342

---

METABOLISM OF POLYAMINES

METABOLISM OF POLYAMINES

	553
set	METABOLISM OF POLYAMINES
setSize	57
pANOVA	1.07e-13
s.dist	0.569
p.adjustANOVA	4.69e-12

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Smox	7730
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Psma4	7495
Psmd13	7414
Psmb4	7374
Psmd3	7229
Psmc4	7224
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Smox	7730
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Psma4	7495
Psmd13	7414
Psmb4	7374
Psmd3	7229
Psmc4	7224
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Oaz1	6405
Oaz2	6349
Psmc1	6270
Azin2	6044
Odc1	5920
Psmc2	5913
Psmd14	5733
Srm	5697
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Nqo1	5146
Psmd12	3996
Psmc6	3784
Sat1	3688
Psmd10	3670
Psmf1	3034
Paox	2877
Psmd6	2341
Psmb8	1878
Azin1	1858
Agmat	1740
Psmd1	1686
Oaz3	635
Sms	237
Psmd2	-281
Psmb9	-1520
Amd1	-3314
Psme3	-4000
Psmd11	-4032
Psmd5	-4580
Psme4	-4962

---

PKA ACTIVATION IN GLUCAGON SIGNALLING

PKA ACTIVATION IN GLUCAGON SIGNALLING

	710
set	PKA ACTIVATION IN GLUCAGON SIGNALLING
setSize	16
pANOVA	0.000115
s.dist	-0.557
p.adjustANOVA	0.000879

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Prkar2a	-8858
Adcy6	-8795
Adcy3	-7802
Adcy5	-7709
Adcy8	-7344
Prkacb	-7235
Adcy2	-6526
Adcy9	-4486
Prkar2b	-3762
Prkar1a	-3133
Prkar1b	-1887
Prkaca	-1090
Adcy1	-640
Gnas	3417

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Adcy4	-9080
Adcy7	-8971
Prkar2a	-8858
Adcy6	-8795
Adcy3	-7802
Adcy5	-7709
Adcy8	-7344
Prkacb	-7235
Adcy2	-6526
Adcy9	-4486
Prkar2b	-3762
Prkar1a	-3133
Prkar1b	-1887
Prkaca	-1090
Adcy1	-640
Gnas	3417

---

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES

	191
set	CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES
setSize	46
pANOVA	8.69e-11
s.dist	0.553
p.adjustANOVA	2.63e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Psma4	7495
Psmd13	7414
Psmb4	7374
Psmd3	7229
Psmc4	7224
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Psma4	7495
Psmd13	7414
Psmb4	7374
Psmd3	7229
Psmc4	7224
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Psmc1	6270
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Mrc1	4179
Psmd12	3996
Psmc6	3784
Psmd10	3670
Psmf1	3034
Psmd6	2341
Psmb8	1878
Psmd1	1686
Psmd2	-281
Psmb9	-1520
Mrc2	-1907
Psme3	-4000
Psmd11	-4032
Psmd5	-4580
Psme4	-4962
Fcgr1	-7025

---

COHESIN LOADING ONTO CHROMATIN

COHESIN LOADING ONTO CHROMATIN

	165
set	COHESIN LOADING ONTO CHROMATIN
setSize	10
pANOVA	0.00269
s.dist	-0.548
p.adjustANOVA	0.0129

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Nipbl	-8451
Pds5b	-7910
Pds5a	-7606
Stag2	-6441
Rad21	-5793
Mau2	-4510
Wapl	-4102
Smc1a	-3291
Stag1	-3077
Smc3	-523

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Nipbl	-8451
Pds5b	-7910
Pds5a	-7606
Stag2	-6441
Rad21	-5793
Mau2	-4510
Wapl	-4102
Smc1a	-3291
Stag1	-3077
Smc3	-523

---

SIGNALING BY HIPPO

SIGNALING BY HIPPO

	965
set	SIGNALING BY HIPPO
setSize	20
pANOVA	2.26e-05
s.dist	-0.547
p.adjustANOVA	0.000224

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Amotl1	-9038
Wwc1	-8850
Wwtr1	-8757
Tjp1	-8192
Stk4	-7897
Yap1	-7464
Amotl2	-7277
Nphp4	-7161
Mob1a	-7095
Lats1	-7088
Dvl2	-6862
Tjp2	-6608
Mob1b	-6521
Sav1	-5864
Lats2	-4165
Amot	-3465
Ywhae	673
Casp3	1034
Stk3	3451
Ywhab	3924

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Amotl1	-9038
Wwc1	-8850
Wwtr1	-8757
Tjp1	-8192
Stk4	-7897
Yap1	-7464
Amotl2	-7277
Nphp4	-7161
Mob1a	-7095
Lats1	-7088
Dvl2	-6862
Tjp2	-6608
Mob1b	-6521
Sav1	-5864
Lats2	-4165
Amot	-3465
Ywhae	673
Casp3	1034
Stk3	3451
Ywhab	3924

---

RRNA PROCESSING

RRNA PROCESSING

	897
set	RRNA PROCESSING
setSize	194
pANOVA	1.95e-39
s.dist	0.546
p.adjustANOVA	2.87e-37

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Xrn2	7991
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Xrn2	7991
Fau	7889
Rpl35	7880
Rplp2	7877
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rrp36	7723
Rps12	7721
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Ddx49	7500
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Tsr3	7436
Wdr18	7427
Nhp2	7421
Rpl9	7416
Rpp25	7294
Rpl21	7270
Rps19	7268
Hsd17b10	7267
Uba52	7262
Rpl29	7250
Nol12	7213
Imp3	7188
Gar1	7151
Rpl30	7145
Rpl8	7137
Nip7	7111
Rps13	7086
Ltv1	7076
Rplp0	7009
Rpl10a	6965
Nop10	6928
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Exosc9	6857
Snu13	6788
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Pes1	6661
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Rpp21	6513
Pno1	6501
Rpl27a	6473
Rps26	6384
Rcl1	6364
Rps3a1	6345
Exosc5	6327
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Exosc2	6188
Fbl	6136
Rps4x	5999
Exosc7	5805
Trmt112	5791
Rpsa	5712
Krr1	5651
Exosc8	5591
Rpl6	5583
Fcf1	5548
Gnl3	5453
Nob1	5386
Ddx52	5358
Utp3	5284
Rrp1	5278
Bop1	5245
Nop56	5221
Mrm2	5061
Mrm3	5053
Mrm1	4982
Wdr46	4876
Tbl3	4813
Dcaf13	4793
Emg1	4785
Eri1	4705
Ddx47	4688
Rpp38	4674
Exosc4	4518
Thumpd1	4454
Exosc1	4434
Bud23	4422
Rpp40	4207
Rrp9	3958
Trmt10c	3820
Rrp7a	3744
Dkc1	3707
Ebna1bp2	3437
Utp11	3289
Rpp14	2980
Ncl	2918
Rpp30	2888
Ftsj3	2863
C1d	2657
Riok3	2620
Noc4l	2492
Rpl10	2228
Wdr43	2017
Riok2	2000
Mtrex	1949
Utp25	1908
Nol11	1648
Elac2	1632
Mphosph10	1478
Mphosph6	1439
Riok1	1412
Pdcd11	1269
Pelp1	1114
Prorp	1109
Senp3	604
Imp4	580
Nsun4	294
Exosc3	46
Nop58	38
Tsr1	-124
Isg20l2	-210
Tfb1m	-267
Wdr36	-693
Nop14	-761
Wdr12	-844
Utp18	-1147
Csnk1d	-1262
Exosc10	-1325
Bms1	-1382
Utp14a	-1600
Mterf4	-1656
Dhx37	-2585
Ddx21	-2647
Pwp2	-2873
Las1l	-2878
Nol9	-3131
Tex10	-3206
Bysl	-3379
Utp6	-3513
Dis3	-3955
Wdr75	-4319
Nat10	-4487
Csnk1e	-4763
Nop2	-5029
Nol6	-5450
Rbm28	-5700
Utp15	-6335
Utp4	-6611
Heatr1	-7687
Utp20	-7746
Dimt1	-8598
Wdr3	-8666

---

SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS

SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS

	1003
set	SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS
setSize	11
pANOVA	0.00197
s.dist	0.539
p.adjustANOVA	0.00988

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Snrpg	8071
Snrpe	8046
Snrpf	7594
Snrpd3	7420
Snrpb	5978
Ncbp2	5725
Slbp	4416
Lsm10	2950
Ncbp1	1338
Zfp473	-194
Lsm11	-4548

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Snrpg	8071
Snrpe	8046
Snrpf	7594
Snrpd3	7420
Snrpb	5978
Ncbp2	5725
Slbp	4416
Lsm10	2950
Ncbp1	1338
Zfp473	-194
Lsm11	-4548

---

PROCESSING OF SMDT1

PROCESSING OF SMDT1

	744
set	PROCESSING OF SMDT1
setSize	16
pANOVA	0.000195
s.dist	0.538
p.adjustANOVA	0.00136

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Smdt1	7625
Parl	7243
Phb2	7087
Phb	6780
Stoml2	6592
Maip1	6266
Pmpca	6174
Micu2	5807
Micu3	5678
Pmpcb	5609
Micu1	4015
Mcub	3200
Spg7	2297
Afg3l2	-613
Yme1l1	-1450
Mcu	-4412

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Smdt1	7625
Parl	7243
Phb2	7087
Phb	6780
Stoml2	6592
Maip1	6266
Pmpca	6174
Micu2	5807
Micu3	5678
Pmpcb	5609
Micu1	4015
Mcub	3200
Spg7	2297
Afg3l2	-613
Yme1l1	-1450
Mcu	-4412

---

STABILIZATION OF P53

STABILIZATION OF P53

	1014
set	STABILIZATION OF P53
setSize	54
pANOVA	6.7e-11
s.dist	0.513
p.adjustANOVA	2.08e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Psmc1	6270
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Psmd12	3996
Psmc6	3784
Psmd10	3670
Mdm2	3579
Trp53	3197
Psmf1	3034
Chek2	2920
Psmd6	2341
Psmb8	1878
Psmd1	1686
Psmd2	-281
Phf20	-847
Cop1	-1350
Psmb9	-1520
Ubc	-2250
Psme3	-4000
Psmd11	-4032
Psmd5	-4580
Psme4	-4962
Atm	-7179
Mdm4	-8409

---

PINK1 PRKN MEDIATED MITOPHAGY

PINK1 PRKN MEDIATED MITOPHAGY

	708
set	PINK1 PRKN MEDIATED MITOPHAGY
setSize	22
pANOVA	3.23e-05
s.dist	0.512
p.adjustANOVA	0.000303

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Tomm7	8227
Map1lc3b	7988
Tomm22	7943
Pink1	7825
Tomm6	7722
Rps27a	7519
Tomm5	7349
Uba52	7262
Ubb	7197
Map1lc3a	6741
Tomm40	6684
Vdac1	5077
Sqstm1	3819
Mfn1	3000
Atg5	2596
Atg12	2426
Mterf3	540
Tomm20	206
Tomm70a	-2163
Ubc	-2250

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Tomm7	8227
Map1lc3b	7988
Tomm22	7943
Pink1	7825
Tomm6	7722
Rps27a	7519
Tomm5	7349
Uba52	7262
Ubb	7197
Map1lc3a	6741
Tomm40	6684
Vdac1	5077
Sqstm1	3819
Mfn1	3000
Atg5	2596
Atg12	2426
Mterf3	540
Tomm20	206
Tomm70a	-2163
Ubc	-2250
Prkn	-2505
Mfn2	-4838

---

ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT

ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT

	7
set	ABORTIVE ELONGATION OF HIV 1 TRANSCRIPT IN THE ABSENCE OF TAT
setSize	23
pANOVA	2.21e-05
s.dist	0.511
p.adjustANOVA	0.000221

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Polr2l	8217
Polr2i	8118
Polr2j	8067
Polr2f	7953
Polr2h	7653
Polr2g	7391
Polr2k	7373
Polr2e	7011
Supt4a	6970
Gtf2f2	6459
Nelfcd	5988
Ncbp2	5725
Polr2c	5408
Nelfe	4751
Polr2d	4021
Nelfb	3767
Gtf2f1	3363
Ctdp1	2747
Ncbp1	1338
Polr2b	-2618

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Polr2l	8217
Polr2i	8118
Polr2j	8067
Polr2f	7953
Polr2h	7653
Polr2g	7391
Polr2k	7373
Polr2e	7011
Supt4a	6970
Gtf2f2	6459
Nelfcd	5988
Ncbp2	5725
Polr2c	5408
Nelfe	4751
Polr2d	4021
Nelfb	3767
Gtf2f1	3363
Ctdp1	2747
Ncbp1	1338
Polr2b	-2618
Nelfa	-4430
Supt5	-6418
Polr2a	-6656

---

SCF SKP2 MEDIATED DEGRADATION OF P27 P21

SCF SKP2 MEDIATED DEGRADATION OF P27 P21

	911
set	SCF SKP2 MEDIATED DEGRADATION OF P27 P21
setSize	58
pANOVA	1.96e-11
s.dist	0.509
p.adjustANOVA	7.22e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Cdkn1a	8015
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Cdkn1a	8015
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Psmc1	6270
Cdk4	6231
Cks1b	6134
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Ccne1	4983
Skp1	4875
Psmd12	3996
Psmc6	3784
Psmd10	3670
Psmf1	3034
Psmd6	2341
Psmb8	1878
Psmd1	1686
Ccne2	-51
Psmd2	-281
Psmb9	-1520
Ubc	-2250
Cdk2	-2490
Cul1	-2566
Cdkn1b	-2773
Psme3	-4000
Psmd11	-4032
Psmd5	-4580
Ccnd1	-5372
Ccna2	-8038
Skp2	-8063

---

RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES

RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES

	780
set	RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASES
setSize	20
pANOVA	8.67e-05
s.dist	-0.507
p.adjustANOVA	0.000715

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Slitrk2	-8943
Slitrk6	-8593
Ppfia2	-7676
Ptprd	-7495
Ppfia3	-7156
Ptprf	-6704
Ntrk3	-6453
Slitrk5	-6164
Slitrk3	-6078
Slitrk1	-5723
Ptprs	-5441
Lrrc4b	-5373
Slitrk4	-5168
Il1rapl1	-3568
Ppfia1	-2853
Ppfia4	-2574
Ppfibp1	-1332
Il1rap	-1162
Ppfibp2	741
Il1rapl2	1482

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Slitrk2	-8943
Slitrk6	-8593
Ppfia2	-7676
Ptprd	-7495
Ppfia3	-7156
Ptprf	-6704
Ntrk3	-6453
Slitrk5	-6164
Slitrk3	-6078
Slitrk1	-5723
Ptprs	-5441
Lrrc4b	-5373
Slitrk4	-5168
Il1rapl1	-3568
Ppfia1	-2853
Ppfia4	-2574
Ppfibp1	-1332
Il1rap	-1162
Ppfibp2	741
Il1rapl2	1482

---

THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT

THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT

	1075
set	THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT
setSize	66
pANOVA	1.33e-12
s.dist	0.505
p.adjustANOVA	5.59e-11

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Cdkn1a	8015
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Tuba8	7467
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Cdkn1a	8015
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Tuba8	7467
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Psmc1	6270
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Fkbpl	4698
Psmd12	3996
Tuba1a	3987
Tubb3	3980
Psmc6	3784
Tubb4a	3742
Psmd10	3670
Tubb4b	3469
Trp53	3197
Psmf1	3034
Tuba4a	3009
Plk1	2582
Psmd6	2341
Tuba1c	2197
Tubb2a	2036
Tuba1b	1910
Psmb8	1878
Psmd1	1686
Gtse1	-105
Psmd2	-281
Tubb6	-996
Psmb9	-1520
Mapre1	-1634
Ubc	-2250
Tubb2b	-3180
Psme3	-4000
Psmd11	-4032
Hsp90ab1	-4099
Psmd5	-4580
Psme4	-4962
Hsp90aa1	-5295

---

REGULATION OF RUNX3 EXPRESSION AND ACTIVITY

REGULATION OF RUNX3 EXPRESSION AND ACTIVITY

	820
set	REGULATION OF RUNX3 EXPRESSION AND ACTIVITY
setSize	53
pANOVA	2.78e-10
s.dist	0.501
p.adjustANOVA	7.44e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Psmc1	6270
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Psma1	5378
Psme2	5280
Psma5	5259
Psmd12	3996
Psmc6	3784
Psmd10	3670
Mdm2	3579
Psmf1	3034
Psmd6	2341
Psmb8	1878
Psmd1	1686
Psmd2	-281
Tgfb1	-509
Psmb9	-1520
Ubc	-2250
Src	-3681
Psme3	-4000
Psmd11	-4032
Smurf1	-4520
Psmd5	-4580
Cbfb	-4841
Ep300	-4856
Smurf2	-7891

---

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO

	792
set	REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO
setSize	10
pANOVA	0.00637
s.dist	-0.498
p.adjustANOVA	0.0259

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Robo1	-8470
Slit1	-7905
Robo3	-7106
Slit2	-6451
Robo2	-5272
Dcc	-4988
Nell2	-4229
Src	-3681
Ntn1	342
Slit3	374

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Robo1	-8470
Slit1	-7905
Robo3	-7106
Slit2	-6451
Robo2	-5272
Dcc	-4988
Nell2	-4229
Src	-3681
Ntn1	342
Slit3	374

---

DEGRADATION OF DVL

DEGRADATION OF DVL

	225
set	DEGRADATION OF DVL
setSize	55
pANOVA	1.84e-10
s.dist	0.497
p.adjustANOVA	5.31e-09

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Rbx1	6958

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Rbx1	6958
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Psmc1	6270
Psmc2	5913
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
Dact1	5533
Psma1	5378
Psme2	5280
Psma5	5259
Psmd12	3996
Psmc6	3784
Psmd10	3670
Psmf1	3034
Psmd6	2341
Klhl12	2007
Psmb8	1878
Psmd1	1686
Dvl1	1408
Psmd2	-281
Psmb9	-1520
Ubc	-2250
Psme3	-4000
Psmd11	-4032
Psmd5	-4580
Psme4	-4962
Cul3	-5825
Dvl2	-6862
Dvl3	-7526
Hecw1	-7675

---

PYROPTOSIS

PYROPTOSIS

	764
set	PYROPTOSIS
setSize	20
pANOVA	0.000128
s.dist	0.495
p.adjustANOVA	0.000966

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Chmp4b	7618
Chmp2a	7038
Bax	6756
Gsdmd	6391
Cycs	6115
Chmp6	6076
Irf1	6055
Chmp2b	5458
Il18	5274
Chmp3	4730
Casp1	4025
Gsdme	3899
Chmp4c	3321
Trp53	3197
Hmgb1	3012
Bak1	3003
Casp3	1034
Irf2	-107
Chmp7	-1429
Trp63	-4081

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Chmp4b	7618
Chmp2a	7038
Bax	6756
Gsdmd	6391
Cycs	6115
Chmp6	6076
Irf1	6055
Chmp2b	5458
Il18	5274
Chmp3	4730
Casp1	4025
Gsdme	3899
Chmp4c	3321
Trp53	3197
Hmgb1	3012
Bak1	3003
Casp3	1034
Irf2	-107
Chmp7	-1429
Trp63	-4081

---

PURINE CATABOLISM

PURINE CATABOLISM

	758
set	PURINE CATABOLISM
setSize	16
pANOVA	0.000645
s.dist	0.493
p.adjustANOVA	0.00378

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Xdh	8180
Nudt16	7945
Nt5c	6653
Nudt9	6623
Itpa	5971
Nudt1	5768
Nudt18	5653
Nt5e	5333
Gda	4547
Pnp2	3114
Nudt5	2613
Adprm	2289
Nudt15	1583
Dnph1	1422
Nt5c2	-2513
Nt5c1a	-3549

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Xdh	8180
Nudt16	7945
Nt5c	6653
Nudt9	6623
Itpa	5971
Nudt1	5768
Nudt18	5653
Nt5e	5333
Gda	4547
Pnp2	3114
Nudt5	2613
Adprm	2289
Nudt15	1583
Dnph1	1422
Nt5c2	-2513
Nt5c1a	-3549

---

METABOLISM OF AMINO ACIDS AND DERIVATIVES

METABOLISM OF AMINO ACIDS AND DERIVATIVES

	544
set	METABOLISM OF AMINO ACIDS AND DERIVATIVES
setSize	317
pANOVA	1.02e-50
s.dist	0.489
p.adjustANOVA	6.01e-48

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rida	8127
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Psmb5	8036
Rpl37a	8035
Rpl32	8005
Psat1	7940
Pstk	7909
Fau	7889
Rpl35	7880
Rplp2	7877
Auh	7876
Rps17	7858

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rida	8127
Rpl39	8121
Rpl38	8113
Rps28	8081
Rpl36	8077
Rpl22	8043
Psmb5	8036
Rpl37a	8035
Rpl32	8005
Psat1	7940
Pstk	7909
Fau	7889
Rpl35	7880
Rplp2	7877
Auh	7876
Rps17	7858
Rpl37	7845
Psma3	7831
Psmb3	7826
Gcsh	7822
Rps14	7821
Rpl36al	7817
Rpl19	7814
Psmb7	7813
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Smox	7730
Rpl31	7729
Rpl34	7726
Rps12	7721
Kyat1	7710
Rpl26	7699
Psmb2	7679
Rps8	7676
Rplp1	7662
Rpl23	7655
Rpl27	7644
Sem1	7641
Ndufab1	7639
Rpl7a	7609
Rpl24	7605
Psmb6	7604
Rps23	7560
Psmd9	7553
Pdhb	7550
Psma7	7531
Rps27a	7519
Rpl36a	7511
Psma4	7495
Rps18	7494
Rpl18	7478
Rps7	7471
Qdpr	7465
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Psmd13	7414
Slc25a21	7413
Psmb4	7374
Dao	7368
Pxmp2	7340
Rpl21	7270
Rps19	7268
Hsd17b10	7267
Uba52	7262
Rpl29	7250
Psmd3	7229
Psmc4	7224
Lias	7223
Nmral1	7204
Psma6	7167
Rpl30	7145
Rpl8	7137
Th	7131
Sds	7129
Rps13	7086
Psmd7	7050
Rplp0	7009
Rpl10a	6965
Ckb	6960
Echs1	6936
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Psph	6865
Psma2	6851
Aimp1	6838
Psme1	6829
Acat1	6813
Gpt2	6801
Rpl13a	6776
Rpl4	6774
Rps3	6754
Gamt	6749
Pycr2	6716
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Gls2	6618
Psmb10	6606
Rpl17	6604
Slc25a13	6600
Psmd8	6594
Rpl27a	6473
Psmb1	6446
Tstd1	6408
Oaz1	6405
Rps26	6384
Gstz1	6366
Oaz2	6349
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Psmc1	6270
Rps20	6232
Hnmt	6205
Rpl12	6198
Acad8	6126
Azin2	6044
Rps4x	5999
Aldh9a1	5991
Txn2	5985
Bckdha	5924
Odc1	5920
Psmc2	5913
Cdo1	5907
Serinc3	5860
Apip	5810
Glul	5773
Hoga1	5743
Psmd14	5733
Rpsa	5712
Srm	5697
Psmc5	5693
Rars	5661
Bckdhb	5646
Psmc3	5625
Dio2	5621
Aimp2	5587
Rpl6	5583
Psmd4	5559
Bbox1	5536
Csad	5495
Sars	5488
Tdo2	5404
Psma1	5378
Mpst	5306
Aspa	5293
Psme2	5280
Psma5	5259
Gcat	5212
Ass1	5162
Nqo1	5146
Sdsl	5065
Ckmt1	5010
Slc25a10	5000
Kars	4985
Gnmt	4925
Lipt1	4840
Prodh	4829
Suox	4683
Grhpr	4541
Pcbd1	4501
Phgdh	4377
Hibadh	4349
Ahcy	4336
Pdhx	4176
Lipt2	4090
Ddo	4077
Naalad2	4022
Sephs2	4018
Psmd12	3996
Eef1e1	3982
Adi1	3960
Aass	3939
Cbs	3934
Hibch	3864
Crym	3831
Psmc6	3784
Mccc2	3756
Mtap	3740
Sat1	3688
Psmd10	3670
Bckdk	3406
Ido2	3282
Pycrl	3237
Amt	3232
Slc7a5	3227
Lars	3073
Gadl1	3050
Psmf1	3034
Dbh	3001
Slc6a8	2961
Paox	2877
Pdha1	2836
Mri1	2776
Asrgl1	2715
Tst	2649
Carns1	2610
Enoph1	2597
Bcat2	2581
Bcat1	2566
Dld	2564
Oat	2506
Asl	2477
Serinc2	2432
Rimkla	2379
Psmd6	2341
Aspg	2229
Rpl10	2228
Got1	2224
Dct	2182
Shmt1	2044
Dlst	1937
Psmb8	1878
Azin1	1858
Slc3a2	1823
Gpt	1772
Sepsecs	1756
Agmat	1740
Psmd1	1686
Aanat	1666
Ethe1	1609
Fah	1593
Sqor	1224
Scly	1184
Gatm	1030
Dars	1026
Arg2	871
Eprs	817
Slc44a1	768
Gcdh	645
Oaz3	635
Glud1	606
Dlat	495
Got2	418
Sms	237
Mars1	200
Phykpl	-15
Ado	-18
Tpo	-42
Psmd2	-281
Hdc	-376
Srr	-823
Pycr1	-938
Slc25a44	-952
Aldh7a1	-971
Tshb	-1085
Aldh4a1	-1141
Gldc	-1160
Qars	-1167
Slc25a15	-1221
Slc5a5	-1440
Gsr	-1485
Psmb9	-1520
Afmid	-1534
Kyat3	-1583
Ddc	-1595
Nat8l	-1740
Asns	-1790
Acadsb	-1855
Secisbp2	-1908
Ivd	-1958
Eefsec	-2058
Tph2	-2061
Aldh6a1	-2099
Dmgdh	-2594
Ido1	-2709
Mtrr	-2961
Slc6a7	-3040
Papss1	-3074
Mtr	-3147
Amd1	-3314
Dhtkd1	-3492
Dbt	-3990
Psme3	-4000
Psmd11	-4032
Hal	-4242
Aldh18a1	-4362
Pipox	-4506
Cth	-4528
Hykk	-4543
Psmd5	-4580
Serinc5	-4592
Txnrd1	-4597
Psme4	-4962
Chdh	-4998
Papss2	-5124
Gls	-5266
Ogdh	-5395
Slc36a4	-5729
Mccc1	-5990
Slc25a12	-6200
Serinc1	-6333
Folh1	-6648
Rimklb	-6746
Ppm1k	-6985
Iars	-7028
Carnmt1	-7102
Sardh	-7561
Bhmt2	-7706
Slc6a11	-8225

---

ANTIMICROBIAL PEPTIDES

ANTIMICROBIAL PEPTIDES

	60
set	ANTIMICROBIAL PEPTIDES
setSize	16
pANOVA	0.000715
s.dist	0.489
p.adjustANOVA	0.0041

Top enriched genes

Top 20 genes

GeneID	Gene Rank
S100a8	8212
Pglyrp1	8142
S100a9	7802
Atox1	7598
Lyz2	7585
Defb42	7364
Pdzd11	5456
Prtn3	5317
Slc11a1	4408
Rnase6	3952
Defb1	3737
Chga	2822
Lcn2	-167
Tlr2	-920
Clu	-2549
Atp7a	-7694

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
S100a8	8212
Pglyrp1	8142
S100a9	7802
Atox1	7598
Lyz2	7585
Defb42	7364
Pdzd11	5456
Prtn3	5317
Slc11a1	4408
Rnase6	3952
Defb1	3737
Chga	2822
Lcn2	-167
Tlr2	-920
Clu	-2549
Atp7a	-7694

---

ASSEMBLY OF THE PRE REPLICATIVE COMPLEX

ASSEMBLY OF THE PRE REPLICATIVE COMPLEX

	78
set	ASSEMBLY OF THE PRE REPLICATIVE COMPLEX
setSize	65
pANOVA	1.36e-11
s.dist	0.485
p.adjustANOVA	5.36e-10

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Gmnn	7669
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Psmb5	8036
Psma3	7831
Psmb3	7826
Psmb7	7813
Psmb2	7679
Gmnn	7669
Sem1	7641
Psmb6	7604
Psmd9	7553
Psma7	7531
Rps27a	7519
Psma4	7495
Psmd13	7414
Psmb4	7374
Uba52	7262
Psmd3	7229
Psmc4	7224
Ubb	7197
Psma6	7167
Psmd7	7050
Psma2	6851
Psme1	6829
Psmb10	6606
Psmd8	6594
Psmb1	6446
Mcm3	6296
Psmc1	6270
Orc5	6206
Psmc2	5913
Orc6	5748
Psmd14	5733
Psmc5	5693
Psmc3	5625
Psmd4	5559
E2f2	5549
Psma1	5378
Psme2	5280
Psma5	5259
Mcm5	4598
Psmd12	3996
E2f1	3915
Psmc6	3784
Mcm7	3753
Psmd10	3670
Psmf1	3034
Orc2	2772
Psmd6	2341
Psmb8	1878
Psmd1	1686
Mcm4	835
Mcm6	558
Mcm2	220
Cdt1	-136
Psmd2	-281
E2f3	-814
Psmb9	-1520
Ubc	-2250
Psme3	-4000
Psmd11	-4032
Psmd5	-4580
Orc4	-4772
Psme4	-4962
Orc1	-7340
Mcm8	-7436
Orc3	-7666

---

SIGNALING BY FGFR2 IIIA TM

SIGNALING BY FGFR2 IIIA TM

	955
set	SIGNALING BY FGFR2 IIIA TM
setSize	19
pANOVA	0.000266
s.dist	0.483
p.adjustANOVA	0.00176

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Polr2l	8217
Polr2i	8118
Polr2j	8067
Polr2f	7953
Polr2h	7653
Polr2g	7391
Polr2k	7373
Polr2e	7011
Gtf2f2	6459
Ncbp2	5725
Polr2c	5408
Polr2d	4021
Gtf2f1	3363
Fgf1	2680
Ncbp1	1338
Polr2b	-2618
Fgf2	-4238
Fgfr2	-5660
Polr2a	-6656

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Polr2l	8217
Polr2i	8118
Polr2j	8067
Polr2f	7953
Polr2h	7653
Polr2g	7391
Polr2k	7373
Polr2e	7011
Gtf2f2	6459
Ncbp2	5725
Polr2c	5408
Polr2d	4021
Gtf2f1	3363
Fgf1	2680
Ncbp1	1338
Polr2b	-2618
Fgf2	-4238
Fgfr2	-5660
Polr2a	-6656

---

INFLUENZA INFECTION

INFLUENZA INFECTION

	446
set	INFLUENZA INFECTION
setSize	145
pANOVA	1e-23
s.dist	0.483
p.adjustANOVA	6.95e-22

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Polr2l	8217
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Polr2i	8118
Rpl38	8113
Rps28	8081
Rpl36	8077
Polr2j	8067
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Polr2f	7953
Fau	7889
Rpl35	7880
Rplp2	7877
Nup54	7871
Rps17	7858

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Polr2l	8217
Rps21	8174
Rps29	8168
Rpl35a	8136
Rps27	8135
Rpl39	8121
Polr2i	8118
Rpl38	8113
Rps28	8081
Rpl36	8077
Polr2j	8067
Rpl22	8043
Rpl37a	8035
Rpl32	8005
Polr2f	7953
Fau	7889
Rpl35	7880
Rplp2	7877
Nup54	7871
Rps17	7858
Rpl37	7845
Rps14	7821
Rpl36al	7817
Rpl19	7814
Rps15	7805
Rps10	7793
Rpl13	7786
Rpl11	7781
Rpl31	7729
Rpl34	7726
Rps12	7721
Rpl26	7699
Rps8	7676
Rplp1	7662
Rpl23	7655
Polr2h	7653
Rpl27	7644
Rpl7a	7609
Rpl24	7605
Rps23	7560
Rps27a	7519
Rpl36a	7511
Rps18	7494
Rpl18	7478
Rps7	7471
Rps9	7456
Rps15a	7440
Rpl18a	7438
Rpl9	7416
Polr2g	7391
Polr2k	7373
Rpl21	7270
Rps19	7268
Uba52	7262
Rpl29	7250
Rpl30	7145
Rpl8	7137
Rps13	7086
Polr2e	7011
Rplp0	7009
Rpl10a	6965
Rpl22l1	6916
Rps16	6913
Rps2	6912
Rpl7	6885
Rps11	6883
Rps25	6881
Rpl14	6873
Rae1	6790
Rpl13a	6776
Rpl4	6774
Rps3	6754
Rps27l	6682
Rps6	6648
Rpl3	6642
Rps24	6631
Rps5	6627
Rpl23a	6619
Rpl17	6604
Grsf1	6562
Rpl27a	6473
Gtf2f2	6459
Rps26	6384
Rps3a1	6345
Rpl28	6319
Rpl15	6281
Rpl5	6276
Rps20	6232
Rpl12	6198
Clta	6101
Sec13	6081
Rps4x	5999
Rpsa	5712
Aaas	5610
Rpl6	5583
Ran	5472
Polr2c	5408
Nup85	4733
Nup107	4316
Polr2d	4021
Kpna2	3804
Gtf2f1	3363
Nup35	2840
Rpl10	2228
Pabpn1	1944
Nup62	1465
Nup43	1374
Nup88	849
Cpsf4	539
Tgfb1	-509
Parp1	-702
Seh1l	-1259
Nupl2	-1391
Ipo5	-1682
Ndc1	-2259
Polr2b	-2618
Nup153	-2717
Nup188	-2906
Nup93	-3493
Nup160	-3619
Nup37	-3635
Kpna4	-4272
Nup214	-4457
Kpna1	-5173
Hsp90aa1	-5295
Eif2ak2	-5648
Nup98	-6071
Calr	-6155
Cltc	-6383
Nup133	-6528
Polr2a	-6656
Tpr	-6677
Ranbp2	-6762
Isg15	-6852
Kpnb1	-6899
Nup50	-6975
Canx	-7313
Pom121	-7600
Dnajc3	-7613
Nup210	-7859
Kpna3	-7906
Xpo1	-8362
Nup205	-8390
Hspa1a	-8452
Nup155	-8677

---

ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS

ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS

	27
set	ACTIVATION OF THE AP 1 FAMILY OF TRANSCRIPTION FACTORS
setSize	10
pANOVA	0.00845
s.dist	-0.481
p.adjustANOVA	0.032

Top enriched genes

Top 20 genes

GeneID	Gene Rank
Fos	-8514
Jun	-7633
Atf2	-7475
Mapk1	-7185
Mapk10	-7114
Mapk9	-6076
Mapk8	-3829
Mapk14	-3757
Mapk11	1027
Mapk3	4669

Click HERE to show all gene set members

All member genes

GeneID	Gene Rank
Fos	-8514
Jun	-7633
Atf2	-7475
Mapk1	-7185
Mapk10	-7114
Mapk9	-6076
Mapk8	-3829
Mapk14	-3757
Mapk11	1027
Mapk3	4669

---

Here is the session info with all the versions of packages used.

sessionInfo()

## R version 4.2.1 (2022-06-23)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] pkgload_1.3.0               GGally_2.1.2               
##  [3] gtools_3.9.3                echarts4r_0.4.4            
##  [5] beeswarm_0.4.0              vioplot_0.3.7              
##  [7] sm_2.2-5.7.1                kableExtra_1.3.4           
##  [9] topconfects_1.12.0          limma_3.52.4               
## [11] eulerr_6.1.1                mitch_1.8.0                
## [13] MASS_7.3-58.1               fgsea_1.22.0               
## [15] gplots_3.1.3                DESeq2_1.36.0              
## [17] SummarizedExperiment_1.26.1 Biobase_2.56.0             
## [19] MatrixGenerics_1.8.1        matrixStats_0.62.0         
## [21] GenomicRanges_1.48.0        GenomeInfoDb_1.32.4        
## [23] IRanges_2.30.1              S4Vectors_0.34.0           
## [25] BiocGenerics_0.42.0         reshape2_1.4.4             
## [27] forcats_0.5.2               stringr_1.4.1              
## [29] dplyr_1.0.10                purrr_0.3.5                
## [31] readr_2.1.3                 tidyr_1.2.1                
## [33] tibble_3.1.8                ggplot2_3.3.6              
## [35] tidyverse_1.3.2             zoo_1.8-11                 
## 
## loaded via a namespace (and not attached):
##   [1] googledrive_2.0.0      colorspace_2.0-3       ellipsis_0.3.2        
##   [4] XVector_0.36.0         fs_1.5.2               rstudioapi_0.14       
##   [7] bit64_4.0.5            AnnotationDbi_1.58.0   fansi_1.0.3           
##  [10] lubridate_1.8.0        xml2_1.3.3             codetools_0.2-18      
##  [13] splines_4.2.1          cachem_1.0.6           knitr_1.40            
##  [16] geneplotter_1.74.0     jsonlite_1.8.2         broom_1.0.1           
##  [19] annotate_1.74.0        dbplyr_2.2.1           png_0.1-7             
##  [22] shiny_1.7.2            compiler_4.2.1         httr_1.4.4            
##  [25] backports_1.4.1        assertthat_0.2.1       Matrix_1.5-1          
##  [28] fastmap_1.1.0          gargle_1.2.1           cli_3.4.1             
##  [31] later_1.3.0            htmltools_0.5.3        tools_4.2.1           
##  [34] gtable_0.3.1           glue_1.6.2             GenomeInfoDbData_1.2.8
##  [37] fastmatch_1.1-3        Rcpp_1.0.9             jquerylib_0.1.4       
##  [40] cellranger_1.1.0       vctrs_0.4.2            Biostrings_2.64.1     
##  [43] svglite_2.1.0          xfun_0.33              rvest_1.0.3           
##  [46] mime_0.12              lifecycle_1.0.3        XML_3.99-0.11         
##  [49] googlesheets4_1.0.1    zlibbioc_1.42.0        scales_1.2.1          
##  [52] hms_1.1.2              promises_1.2.0.1       parallel_4.2.1        
##  [55] RColorBrewer_1.1-3     yaml_2.3.5             memoise_2.0.1         
##  [58] gridExtra_2.3          sass_0.4.2             reshape_0.8.9         
##  [61] stringi_1.7.8          RSQLite_2.2.18         highr_0.9             
##  [64] genefilter_1.78.0      caTools_1.18.2         BiocParallel_1.30.3   
##  [67] systemfonts_1.0.4      rlang_1.0.6            pkgconfig_2.0.3       
##  [70] bitops_1.0-7           evaluate_0.17          lattice_0.20-45       
##  [73] htmlwidgets_1.5.4      bit_4.0.4              tidyselect_1.2.0      
##  [76] plyr_1.8.7             magrittr_2.0.3         R6_2.5.1              
##  [79] generics_0.1.3         DelayedArray_0.22.0    DBI_1.1.3             
##  [82] pillar_1.8.1           haven_2.5.1            withr_2.5.0           
##  [85] survival_3.4-0         KEGGREST_1.36.3        RCurl_1.98-1.9        
##  [88] modelr_0.1.9           crayon_1.5.2           KernSmooth_2.23-20    
##  [91] utf8_1.2.2             rmarkdown_2.17         tzdb_0.3.0            
##  [94] locfit_1.5-9.6         grid_4.2.1             readxl_1.4.1          
##  [97] data.table_1.14.2      blob_1.2.3             webshot_0.5.4         
## [100] reprex_2.0.2           digest_0.6.29          xtable_1.8-4          
## [103] httpuv_1.6.6           munsell_0.5.0          viridisLite_0.4.1     
## [106] bslib_0.4.0

END of report